157d A 12 1.8 URS000080E0B7_32630 7922026 32630 cgcgaauuagcg ............ ............ CRYSTAL AND MOLECULAR STRUCTURE OF R(CGCGAAUUAGCG): AN RNA DUPLEX CONTAINING TWO G(ANTI).A(ANTI) BASE-PAIRS; RNA (5'-R(*CP*GP*CP*GP*AP*AP*UP*UP*AP*GP*CP*G)-3') 157d B 12 1.8 URS000080E0B7_32630 7922026 32630 cgcgaauuagcg ............ ............ CRYSTAL AND MOLECULAR STRUCTURE OF R(CGCGAAUUAGCG): AN RNA DUPLEX CONTAINING TWO G(ANTI).A(ANTI) BASE-PAIRS; RNA (5'-R(*CP*GP*CP*GP*AP*AP*UP*UP*AP*GP*CP*G)-3') 1a34 B 10 1.81 URS000080DEB3_32630 9514737 32630 aaaaaaaaaa .......... .......... SATELLITE TOBACCO MOSAIC VIRUS/RNA COMPLEX; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 1a34 C 10 1.81 URS00002C5188_32630 9514737 32630 uuuuuuuuuu .......... .......... SATELLITE TOBACCO MOSAIC VIRUS/RNA COMPLEX; RNA (5'-R(P*UP*UP*UP*UP*UP*UP*UP*UP*UP*U)-3') 1a3m A 14 NA URS000080DDDA_32630 9514734 32630 ggcgucacaccuuc .............. .............. PAROMOMYCIN BINDING INDUCES A LOCAL CONFORMATIONAL CHANGE IN THE A SITE OF 16S RRNA, NMR, 20 STRUCTURES; 16S RRNA (5'-R(*GP*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*UP*UP*C)-3') 1a3m B 13 NA URS000080E25F_32630 9514734 32630 gggugaagucgcc ............. ............. PAROMOMYCIN BINDING INDUCES A LOCAL CONFORMATIONAL CHANGE IN THE A SITE OF 16S RRNA, NMR, 20 STRUCTURES; 16S RRNA (5'-R(*GP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*CP*C)-3') 1a4d A 21 NA URS000080E377_562 9438864 562 ggccgaugguagugugggguc ..................... ..................... LOOP D/LOOP E ARM OF ESCHERICHIA COLI 5S RRNA, NMR, MINIMIZED AVERAGE STRUCTURE; RNA (5'-R(*GP*GP*CP*CP*GP*AP*UP*GP*GP*UP*AP*GP*UP*GP*UP*GP*GP*GP*GP*UP*C)-3') 1a4d B 20 NA URS000080DFD5_562 9438864 562 uccccaugcgagaguaggcc .................... .................... LOOP D/LOOP E ARM OF ESCHERICHIA COLI 5S RRNA, NMR, MINIMIZED AVERAGE STRUCTURE; RNA (5'-R(P*UP*CP*CP*CP*CP*AP*UP*GP*CP*GP*AP*GP*AP*GP*UP*AP*GP*GP*CP*C)-3') 1ajl A 12 NA URS000080E014_5911 9254623 5911 gguaauaagcuc ............ ............ FIVE-NUCLEOTIDE BULGE LOOP FROM TETRAHYMENA THERMOPHILA GROUP I INTRON; RNA (5'-R(*GP*GP*UP*AP*AP*UP*AP*AP*GP*CP*UP*C)-3') 1ajt A 12 NA URS000080E014_32630 9254623 32630 gguaauaagcuc ............ ............ FIVE-NUCLEOTIDE BULGE LOOP FROM TETRAHYMENA THERMOPHILA GROUP I INTRON, NMR, 1 STRUCTURE; RNA (5'-R(*GP*GP*UP*AP*AP*UP*AP*AP*GP*CP*UP*C)-3') 1al5 A 12 NA URS000080E287_32630 9185574 32630 cgcaaauuugcg ............ ............ A-TRACT RNA DODECAMER, NMR, 12 STRUCTURES; RNA (5'-R(*CP*GP*CP*AP*AP*AP*UP*UP*UP*GP*CP*G)-3') 1al5 B 12 NA URS000080E287_32630 9185574 32630 cgcaaauuugcg ............ ............ A-TRACT RNA DODECAMER, NMR, 12 STRUCTURES; RNA (5'-R(*CP*GP*CP*AP*AP*AP*UP*UP*UP*GP*CP*G)-3') 1aq3 S 12 2.8 URS000080DDB6_32630 9469847 32630 ugaggauuaccc ...<<....>>. .(.((....))) BACTERIOPHAGE MS2 CAPSID PROTEIN/RNA COMPLEX; RNA (5'-R(*AP*CP*AP*UP*GP*AP*GP*GP*AP*UP*UP*AP*CP*CP*CP*AP*U P*GP*U)-3') 1aq4 S 14 3.0 URS000080DDB6_12022 9469847 12022 augaggauuaccca .<<.<<....>>>> .((.((....)))) STRUCTURE OF A MS2 COAT PROTEIN MUTANT IN COMPLEX WITH AN RNA OPERATOR; RNA (5'-R(*AP*CP*AP*UP*GP*AP*GP*GP*AP*UP*UP*AP*CP*CP*CP*AP*U P*GP*U)-3') 1bau A 23 NA URS000080E0ED_11676 9628479 11676 ggcaaugaagcgcgcacguugcc <<<<<<...........>>>>>> ((((((...........)))))) NMR STRUCTURE OF THE DIMER INITIATION COMPLEX OF HIV-1 GENOMIC RNA, MINIMIZED AVERAGE STRUCTURE; SL1 RNA DIMER 1bau B 23 NA URS000080E0ED_11676 9628479 11676 ggcaaugaagcgcgcacguugcc <<<<<<...........>>>>>> ((((((...........)))))) NMR STRUCTURE OF THE DIMER INITIATION COMPLEX OF HIV-1 GENOMIC RNA, MINIMIZED AVERAGE STRUCTURE; SL1 RNA DIMER 1bj2 A 21 NA URS000080DDBD_32630 9739090 32630 ggcaacggaugguucguugcc <<<<<<<.......>>>>>>> (((((((.......))))))) RNA LOOP-LOOP COMPLEX: THE COLE1 INVERTED LOOP SEQUENCE, NMR, 8 STRUCTURES; RNA (5'-R(*GP*GP*CP*AP*AP*CP*GP*GP*AP*UP*GP*GP*UP*UP*CP*GP*UP*UP*GP*CP*C)-3') 1bj2 B 19 NA URS000080E325_32630 9739090 32630 gcaccgaaccauccggugc <<<<<<.......>>>>>> ((((((.......)))))) RNA LOOP-LOOP COMPLEX: THE COLE1 INVERTED LOOP SEQUENCE, NMR, 8 STRUCTURES; RNA (5'-R(*GP*CP*AP*CP*CP*GP*AP*AP*CP*CP*AP*UP*CP*CP*GP*GP*UP*GP*C)-3') 1csl A 13 1.6 URS000080DDF9_32630 10656783 32630 aacgggcgcagaa ............. ............. CRYSTAL STRUCTURE OF THE RRE HIGH AFFINITY SITE; 5'-R(*AP*AP*CP*GP*GP*GP*CP*GP*CP*AP*GP*AP*A)-3' 1csl B 15 1.6 URS000080E02D_32630 10656783 32630 ucugacgguacguuu ............... ............... CRYSTAL STRUCTURE OF THE RRE HIGH AFFINITY SITE; 5'-R(*UP*CP*UP*GP*AP*CP*GP*GP*UP*AP*CP*GP*UP*UP*U)-3' 1d4r A 29 2.0 URS000080DDD1_9606 10574798 9606 ngugaccucccgggagcgggggaccacun ............................. ............................. 29-mer fragment of human srp rna helix 6; 29-MER OF MODIFIED SRP RNA HELIX 6 1d4r B 29 2.0 URS000080DDD1_9606 10574798 9606 ngugaccucccgggagcgggggaccacua ............................. ............................. 29-mer fragment of human srp rna helix 6; 29-MER OF MODIFIED SRP RNA HELIX 6 1d4r C 29 2.0 URS000080DDD1_9606 10574798 9606 ngugaccucccgggagcgggggaccacua ............................. ............................. 29-mer fragment of human srp rna helix 6; 29-MER OF MODIFIED SRP RNA HELIX 6 1dfu M 19 1.8 URS000080E19E_32630 10696113 32630 cccaugcgagaguagggac ................... ................... CRYSTAL STRUCTURE OF E.COLI RIBOSOMAL PROTEIN L25 COMPLEXED WITH A 5S RRNA FRAGMENT AT 1.8 A RESOLUTION; 5S RRNA 1dfu N 19 1.8 URS000080DF0F_32630 10696113 32630 ugccgaugguagugugggg ................... ................... CRYSTAL STRUCTURE OF E.COLI RIBOSOMAL PROTEIN L25 COMPLEXED WITH A 5S RRNA FRAGMENT AT 1.8 A RESOLUTION; 5S RRNA 1di2 C 10 1.9 URS000080E216_32630 9857205 32630 ggcgcgcgcc .......... .......... CRYSTAL STRUCTURE OF A DSRNA-BINDING DOMAIN COMPLEXED WITH DSRNA: MOLECULAR BASIS OF DOUBLE-STRANDED RNA-PROTEIN INTERACTIONS; RNA (5'-R(*GP*GP*CP*GP*CP*GP*CP*GP*CP*C)-3') 1di2 D 10 1.9 URS000080E216_32630 9857205 32630 ggcgcgcgcc .......... .......... CRYSTAL STRUCTURE OF A DSRNA-BINDING DOMAIN COMPLEXED WITH DSRNA: MOLECULAR BASIS OF DOUBLE-STRANDED RNA-PROTEIN INTERACTIONS; RNA (5'-R(*GP*GP*CP*GP*CP*GP*CP*GP*CP*C)-3') 1di2 E 10 1.9 URS000080E216_32630 9857205 32630 ggcgcgcgcc .......... .......... CRYSTAL STRUCTURE OF A DSRNA-BINDING DOMAIN COMPLEXED WITH DSRNA: MOLECULAR BASIS OF DOUBLE-STRANDED RNA-PROTEIN INTERACTIONS; RNA (5'-R(*GP*GP*CP*GP*CP*GP*CP*GP*CP*C)-3') 1di2 G 10 1.9 URS000080E216_32630 9857205 32630 ggcgcgcgcc .......... .......... CRYSTAL STRUCTURE OF A DSRNA-BINDING DOMAIN COMPLEXED WITH DSRNA: MOLECULAR BASIS OF DOUBLE-STRANDED RNA-PROTEIN INTERACTIONS; RNA (5'-R(*GP*GP*CP*GP*CP*GP*CP*GP*CP*C)-3') 1dqf B 10 2.2 URS000080E151_32630 10999608 32630 cagggucggc .......... .......... CRYSTAL STRUCTURE OF HELIX II OF THE X. LAEVIS SOMATIC 5S RRNA WITH A CYTOSINE BULGE IN TWO CONFORMATIONS; RNA (5'-R(*CP*AP*GP*GP*GP*UP*CP*GP*GP*C)-3') 1dqh B 10 1.7 URS000080E151_32630 10999608 32630 cagggucggc .......... .......... CRYSTAL STRUCTURE OF HELIX II OF THE X. LAEVIS SOMATIC 5S RRNA WITH A CYTOSINE BULGE IN TWO CONFORMATIONS; RNA (5'-R(*CP*AP*GP*GP*GP*UP*CP*GP*GP*C)-3') 1duh A 45 2.7 RF00169 URS000080E0AE_32630 10801497 0006617 0048501 32630 cucuguuuaccaggucagguccggaaggaagcagccaaggcagan ............................................. ............................................. CRYSTAL STRUCTURE OF THE CONSERVED DOMAIN IV OF E. COLI 4.5S RNA; 4.5S RNA DOMAIN IV 1duq A 12 2.1 URS000080DFAD_32630 10792052 32630 gcugggcgcagg ............ ............ CRYSTAL STRUCTURE OF THE REV BINDING ELEMENT OF HIV-1; THE REV BINDING ELEMENT 1duq B 14 2.1 URS000080DE8A_32630 10792052 32630 ccugacgguacagc .............. .............. CRYSTAL STRUCTURE OF THE REV BINDING ELEMENT OF HIV-1; THE REV BINDING ELEMENT 1duq C 12 2.1 URS000080DFAD_32630 10792052 32630 gcugggcgcagg ............ ............ CRYSTAL STRUCTURE OF THE REV BINDING ELEMENT OF HIV-1; THE REV BINDING ELEMENT 1duq D 14 2.1 URS000080DE8A_32630 10792052 32630 ccugacgguacagc .............. .............. CRYSTAL STRUCTURE OF THE REV BINDING ELEMENT OF HIV-1; THE REV BINDING ELEMENT 1duq E 12 2.1 URS000080DFAD_32630 10792052 32630 gcugggcgcagg ............ ............ CRYSTAL STRUCTURE OF THE REV BINDING ELEMENT OF HIV-1; THE REV BINDING ELEMENT 1duq F 14 2.1 URS000080DE8A_32630 10792052 32630 ccugacgguacagc .............. .............. CRYSTAL STRUCTURE OF THE REV BINDING ELEMENT OF HIV-1; THE REV BINDING ELEMENT 1duq G 12 2.1 URS000080DFAD_32630 10792052 32630 gcugggcgcagg ............ ............ CRYSTAL STRUCTURE OF THE REV BINDING ELEMENT OF HIV-1; THE REV BINDING ELEMENT 1duq H 14 2.1 URS000080DE8A_32630 10792052 32630 ccugacgguacagc .............. .............. CRYSTAL STRUCTURE OF THE REV BINDING ELEMENT OF HIV-1; THE REV BINDING ELEMENT 1dz5 C 22 NA URS000080DE18_9606 10742179 9606 gagacauugcacccggagucuc ...................... ...................... The NMR structure of the 38KDa U1A protein-PIE RNA complex reveals the basis of cooperativity in regulation of polyadenylation by human U1A protein; PIE, RNA (5'-R(*GP*AP*GP*AP*CP*AP*UP*UP*GP*CP*AP*CP*CP* CP*GP*GP*AP*GP*UP*CP*UP*C)-3') 1dz5 D 22 NA URS000080DE18_9606 10742179 9606 gagacauugcacccggagucuc ...................... ...................... The NMR structure of the 38KDa U1A protein-PIE RNA complex reveals the basis of cooperativity in regulation of polyadenylation by human U1A protein; PIE, RNA (5'-R(*GP*AP*GP*AP*CP*AP*UP*UP*GP*CP*AP*CP*CP* CP*GP*GP*AP*GP*UP*CP*UP*C)-3') 1elh A 12 NA URS000080E111_562 1371071 562 uugccuggcggc ............ ............ NMR ANALYSIS OF HELIX I FROM THE 5S RNA OF ESCHERICHIA COLI; RNA (5'-R(*UP*UP*GP*CP*CP*UP*GP*GP*CP*GP*GP*C)-3') 1elh B 13 NA URS000080DD78_562 1371071 562 aacugccaggcau ............. ............. NMR ANALYSIS OF HELIX I FROM THE 5S RNA OF ESCHERICHIA COLI; RNA (5'-R(*AP*AP*CP*UP*GP*CP*CP*AP*GP*GP*CP*AP*U)-3') 1f27 A 19 1.3 URS000080E0B3_32630 10698630 32630 accgucagaggacacgguu <<<<<........>>>>>. (((((........))))). CRYSTAL STRUCTURE OF A BIOTIN-BINDING RNA PSEUDOKNOT; RNA (5'-R(*AP*CP*CP*GP*UP*CP*AP*GP*AP*GP*GP*AP*CP*AP*CP*GP*GP*UP*U)-3') 1f27 B 11 1.3 URS000080DF5E_32630 10698630 32630 aaaaaguccuc ........... ........... CRYSTAL STRUCTURE OF A BIOTIN-BINDING RNA PSEUDOKNOT; RNA (5'-R(*AP*AP*AP*AP*AP*GP*UP*CP*CP*UP*C)-3') 1f5g A 10 NA URS000080DE87_32630 10995243 32630 gcaggcgugc .......... .......... The G7(syn)-G4(anti) structure of r(GCAGGCGUGC)2; 5'-R(*GP*CP*AP*GP*GP*CP*GP*UP*GP*C)-3' 1f5g B 10 NA URS000080DE87_32630 10995243 32630 gcaggcgugc .......... .......... The G7(syn)-G4(anti) structure of r(GCAGGCGUGC)2; 5'-R(*GP*CP*AP*GP*GP*CP*GP*UP*GP*C)-3' 1f5h A 10 NA URS000080DE87_32630 10995243 32630 gcaggcgugc .......... .......... The G7(syn)-G4(anti) structure of r(GCAGGCGUGC)2; 5'-R(*GP*CP*AP*GP*GP*CP*GP*UP*GP*C)-3' 1f5h B 10 NA URS000080DE87_32630 10995243 32630 gcaggcgugc .......... .......... The G7(syn)-G4(anti) structure of r(GCAGGCGUGC)2; 5'-R(*GP*CP*AP*GP*GP*CP*GP*UP*GP*C)-3' 1f5u A 18 NA URS000080DEA8_32630 10931958 32630 ggugggagacgucccacc <<<<<<<....>>>>>>> (((((((....))))))) SOLUTION STRUCTURE OF THE KISSING DIMER OF H3 GACG STEM-LOOP IN THE 5'-END DIMERIZATION SIGNAL OF MOLONEY MURINE LEUKEMIA VIRUS GENOMIC RNA; RNA (5'-R(*GP*GP*UP*GP*GP*GP*AP*GP*AP*CP*GP*UP*CP*CP*CP*AP*CP*C)-3') 1f5u B 18 NA URS000080DEA8_32630 10931958 32630 ggugggagacgucccacc <<<<<<<....>>>>>>> (((((((....))))))) SOLUTION STRUCTURE OF THE KISSING DIMER OF H3 GACG STEM-LOOP IN THE 5'-END DIMERIZATION SIGNAL OF MOLONEY MURINE LEUKEMIA VIRUS GENOMIC RNA; RNA (5'-R(*GP*GP*UP*GP*GP*GP*AP*GP*AP*CP*GP*UP*CP*CP*CP*AP*CP*C)-3') 1f8v R 25 3.0 URS000080E0CB_103782 11135676 103782 uuuuuuuuuuuuuaaaauuuuuuuu ......................... ......................... THE STRUCTURE OF PARIACOTO VIRUS REVEALS A DODECAHEDRAL CAGE OF DUPLEX RNA; RNA 1fcw A 76 17.0 RF00005 URS000011107D_4932 10931859 0030533 0006412 4932 gcggauuuancucagnngggagagcnccaganunaagaunuggagnucnugugnucgnuccacagaauucgcacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((.........)))).....(((((..]....)))))))))))).... TRNA POSITIONS DURING THE ELONGATION CYCLE; TRNAPHE 1fcw B 76 17.0 RF00005 URS000011107D_4932 10931859 0030533 0006412 4932 gcggauuuancucagnngggagagcnccaganunaagaunuggagnucnugugnucgnuccacagaauucgcacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((.........)))).....(((((..]....)))))))))))).... TRNA POSITIONS DURING THE ELONGATION CYCLE; TRNAPHE 1fcw C 76 17.0 RF00005 URS000011107D_4932 10931859 0030533 0006412 4932 gcggauuuancucagnngggagagcnccaganunaagaunuggagnucnugugnucgnuccacagaauucgcacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((.........)))).....(((((..]....)))))))))))).... TRNA POSITIONS DURING THE ELONGATION CYCLE; TRNAPHE 1fcw D 76 17.0 RF00005 URS000011107D_4932 10931859 0030533 0006412 4932 gcggauuuancucagnngggagagcnccaganunaagaunuggagnucnugugnucgnuccacagaauucgcacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((.........)))).....(((((..]....)))))))))))).... TRNA POSITIONS DURING THE ELONGATION CYCLE; TRNAPHE 1fcw E 76 17.0 RF00005 URS000011107D_4932 10931859 0030533 0006412 4932 gcggauuuancucagnngggagagcnccaganunaagaunuggagnucnugugnucgnuccacagaauucgcacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((.........)))).....(((((..]....)))))))))))).... TRNA POSITIONS DURING THE ELONGATION CYCLE; TRNAPHE 1feu B 19 2.3 URS000080E277_32630 11418764 32630 gccgaugguaguguggggu ................... ................... CRYSTAL STRUCTURE OF RIBOSOMAL PROTEIN TL5, ONE OF THE CTC FAMILY PROTEINS, COMPLEXED WITH A FRAGMENT OF 5S RRNA.; 19 NT FRAGMENT OF 5S RRNA 1feu C 21 2.3 URS000080E275_32630 11418764 32630 ccccaugcgagaguagggaac ..................... ..................... CRYSTAL STRUCTURE OF RIBOSOMAL PROTEIN TL5, ONE OF THE CTC FAMILY PROTEINS, COMPLEXED WITH A FRAGMENT OF 5S RRNA.; 21 NT FRAGMENT OF 5S RRNA 1feu E 19 2.3 URS000080E277_32630 11418764 32630 gccgaugguaguguggggu ................... ................... CRYSTAL STRUCTURE OF RIBOSOMAL PROTEIN TL5, ONE OF THE CTC FAMILY PROTEINS, COMPLEXED WITH A FRAGMENT OF 5S RRNA.; 19 NT FRAGMENT OF 5S RRNA 1feu F 21 2.3 URS000080E275_32630 11418764 32630 ccccaugcgagaguagggaac ..................... ..................... CRYSTAL STRUCTURE OF RIBOSOMAL PROTEIN TL5, ONE OF THE CTC FAMILY PROTEINS, COMPLEXED WITH A FRAGMENT OF 5S RRNA.; 21 NT FRAGMENT OF 5S RRNA 1ffk 0 2706 2.4 RF02540,RF00002 URS000080DFCD_2238 10937989 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagccauggggagccgcacggaggcgaagaaccauggauuuccgaaugagaaucucuacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaaugugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucucgacgaagucucuuggaacagagcgugauacagggugacaaccccguacucgagaccaguacgacgugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccucgacgaaugaccgacgcgcgagcguccaguaagacucacgggaagccgauguucugucguacguuuugaaaaacgagccagggagugugucugcauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgccguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaaguaggggugaaaacuccuauggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucauaccgcaacucgacuaugacgaaaugggaaacggguuaauauucccgugccacuaugcagugaaaguugacgcccuggggucgaucacgcugggcaucgcccagucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcauaguguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcgaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggcuaucucagccggggacccggcgaagagugcaagagcaaaagauagcuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugagguuguucgccuauuaaaggaggucgugagcuggguuuagaccgucgugagacaggucggcugcuaucuacuggguguguggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>...<<<<<.....<<.....>>....>>>>>...<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<..<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>..>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<..<<.........<<<<<....>>>>>.........>>..>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<...<<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>>.<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<.<<<.....>>>.>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<..>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<<...<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>.>>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>...<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))()..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......(..(.....(((((((....({((((......)))))[[......(((....}]])))....)))))))......)..)...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......(...(((.....))).............)).....)))))))))......(.((((((((((....((((((..((....(....(((((....))))).....)...))..))))..)).)))))))))).<.(((........))).((((((....(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))....))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..(...)..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))...((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. CRYSTAL STRUCTURE OF THE LARGE RIBOSOMAL SUBUNIT FROM HALOARCULA MARISMORTUI AT 2.4 ANGSTROM RESOLUTION; 23S RRNA 1ffk 9 122 2.4 RF00001 URS00003592C7_2238 10937989 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccggggaguacuggagugcgcgagccucugggaaacccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<<.............>>>>..>>....>>>>>>.>><..<<<<<.....<<<<<<.<<....>>>>>>>>....>>>>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...(((((.....((((((.((....))))))))....)))))...))))))... CRYSTAL STRUCTURE OF THE LARGE RIBOSOMAL SUBUNIT FROM HALOARCULA MARISMORTUI AT 2.4 ANGSTROM RESOLUTION; 5S RRNA 1ffz A 496 3.2 RF02540 URS000080E2C7_2238 10937990 0003735 0005840 2238 uuccagugcggagucuggagacacccagggggaagcgaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggcuaucucagccggggacccggcgaagagugcaagagcaaaagauagcuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugagguuguucgccuauuaaaggaggucgugagcuggguuuagaccgucgugagacaggucggcugcuaucuacugggugugu <<<<<<........>>>>>>.<<<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>....<<.....>>...<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.......>>>>>>>>>>..........>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>>>... .(((((........)))))..(((((((..(((.((.......(((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.......))))))))))....).....))))..)))))........((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))... LARGE RIBOSOMAL SUBUNIT COMPLEXED WITH R(CC)-DA-PUROMYCIN; 23S RIBOSOMAL RNA 1fg0 A 496 3.0 RF02540 URS000080E2C7_2238 10937990 0003735 0005840 2238 uuccagugcggagucuggagacacccagggggaagcgaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggcuaucucagccggggacccggcgaagagugcaagagcaaaagauagcuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugagguuguucgccuauuaaaggaggucgugagcuggguuuagaccgucgugagacaggucggcugcuaucuacugggugugu <<<<<<........>>>>>>.<<<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>....<<.....>>...<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.......>>>>>>>>>>..........>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<.<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>..<<<<.....>>>>......>>>>>..>...>>>..>....<<<.<<<....>>>..>>>....>>..>>>.>>>>>>>... .(((((........)))))..(((((((..(((.((.......(((.((((.(..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.......))))))))))....).....).))..)))))........((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))... LARGE RIBOSOMAL SUBUNIT COMPLEXED WITH A 13 BP MINIHELIX-PUROMYCIN COMPOUND; 23S RIBOSOMAL RNA 1fjg A 1507 3.0 RF00177,RF01959,RF01960 URS000080E226_274 11014183 0003735 0005840 274 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggauca ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<.......>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<<....>>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.....)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((.......(((((....))))).....((........)).....)))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..((...(((.....)))).)...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... STRUCTURE OF THE THERMUS THERMOPHILUS 30S RIBOSOMAL SUBUNIT IN COMPLEX WITH THE ANTIBIOTICS STREPTOMYCIN, SPECTINOMYCIN, AND PAROMOMYCIN; 16S RIBOSOMAL RNA 1foq A 109 20.0 RF00044 URS000080E166_10756 11130079 10756 ucaagguacgguacuuuugucauguguauguggggauuaaacccugauuaguucagcccacauacuuuguugauugguugucaaucauggcaaaagugccguacuuuga <<<<<<<<<<<<<<<<<<<<<<<..<<<<<<<<<.........<<<<.....>>>>>>>>>>>>>...<<<<<.......>>>>>.>>>>>>>>>>>>>>>>>>>>>>> ((((((((((((((((((((((((.(((((((((.........((((.....)))))))))))))....(((((.....))))).)))))))))))))))))))))))) PENTAMERIC MODEL OF THE BACTERIOPHAGE PHI29 PROHEAD RNA; BACTERIOPHAGE PHI29 PROHEAD RNA 1foq B 109 20.0 RF00044 URS000080E166_10756 11130079 10756 ucaagguacgguacuuuugucauguguauguggggauuaaacccugauuaguucagcccacauacuuuguugauugguugucaaucauggcaaaagugccguacuuuga <<<<<<<<<<<<<<<<<<<<<<<..<<<<<<<<<.........<<<<.....>>>>>>>>>>>>>...<<<<<.......>>>>>.>>>>>>>>>>>>>>>>>>>>>>> ((((((((((((((((((((((((.(((((((((.........((((.....)))))))))))))....(((((.....))))).)))))))))))))))))))))))) PENTAMERIC MODEL OF THE BACTERIOPHAGE PHI29 PROHEAD RNA; BACTERIOPHAGE PHI29 PROHEAD RNA 1foq C 109 20.0 RF00044 URS000080E166_10756 11130079 10756 ucaagguacgguacuuuugucauguguauguggggauuaaacccugauuaguucagcccacauacuuuguugauugguugucaaucauggcaaaagugccguacuuuga <<<<<<<<<<<<<<<<<<<<<<<..<<<<<<<<<.........<<<<.....>>>>>>>>>>>>>...<<<<<.......>>>>>.>>>>>>>>>>>>>>>>>>>>>>> ((((((((((((((((((((((((.(((((((((.........((((.....)))))))))))))....(((((.....))))).)))))))))))))))))))))))) PENTAMERIC MODEL OF THE BACTERIOPHAGE PHI29 PROHEAD RNA; BACTERIOPHAGE PHI29 PROHEAD RNA 1foq D 109 20.0 RF00044 URS000080E166_10756 11130079 10756 ucaagguacgguacuuuugucauguguauguggggauuaaacccugauuaguucagcccacauacuuuguugauugguugucaaucauggcaaaagugccguacuuuga <<<<<<<<<<<<<<<<<<<<<<<..<<<<<<<<<.........<<<<.....>>>>>>>>>>>>>...<<<<<.......>>>>>.>>>>>>>>>>>>>>>>>>>>>>> ((((((((((((((((((((((((.(((((((((.........((((.....)))))))))))))....(((((.....))))).)))))))))))))))))))))))) PENTAMERIC MODEL OF THE BACTERIOPHAGE PHI29 PROHEAD RNA; BACTERIOPHAGE PHI29 PROHEAD RNA 1foq E 109 20.0 RF00044 URS000080E166_10756 11130079 10756 ucaagguacgguacuuuugucauguguauguggggauuaaacccugauuaguucagcccacauacuuuguugauugguugucaaucauggcaaaagugccguacuuuga <<<<<<<<<<<<<<<<<<<<<<<..<<<<<<<<<.........<<<<.....>>>>>>>>>>>>>...<<<<<.......>>>>>.>>>>>>>>>>>>>>>>>>>>>>> ((((((((((((((((((((((((.(((((((((.........((((.....)))))))))))))....(((((.....))))).)))))))))))))))))))))))) PENTAMERIC MODEL OF THE BACTERIOPHAGE PHI29 PROHEAD RNA; BACTERIOPHAGE PHI29 PROHEAD RNA 1fuf A 14 1.7 URS000080E241_32630 11680847 32630 gguauuucgguanc .............. .............. CRYSTAL STRUCTURE OF A 14BP RNA OLIGONUCLEOTIDE CONTAINING DOUBLE UU BULGES: A NOVEL INTRAMOLECULAR U*(AU) BASE TRIPLE; (5'-R(*GP*GP*UP*AP*UP*UP*UP*CP*GP*GP*UP*AP*(CBR)P*C)-3') 1fuf B 14 1.7 URS000080E241_32630 11680847 32630 gguauuucgguanc .............. .............. CRYSTAL STRUCTURE OF A 14BP RNA OLIGONUCLEOTIDE CONTAINING DOUBLE UU BULGES: A NOVEL INTRAMOLECULAR U*(AU) BASE TRIPLE; (5'-R(*GP*GP*UP*AP*UP*UP*UP*CP*GP*GP*UP*AP*(CBR)P*C)-3') 1g1x D 40 2.6 URS000080E268_32630 10753109 32630 aaggcggccgaaaggcuagacggugggagaggguggugga ......<<<....>>>........................ ......(((....)))........................ STRUCTURE OF RIBOSOMAL PROTEINS S15, S6, S18, AND 16S RIBOSOMAL RNA; 16S RIBOSOMAL RNA 1g1x E 44 2.6 URS000080E2CD_32630 10753109 32630 acgccgauggcgaaggcagccaccugguccacccgugacgcuuu .........<<....>>........................... .........((....))........................... STRUCTURE OF RIBOSOMAL PROTEINS S15, S6, S18, AND 16S RIBOSOMAL RNA; 16S RIBOSOMAL RNA 1g1x I 41 2.6 URS000080E268_32630 10753109 32630 aaggcggccgaaaggcuagacggugggagagggugguggaa ......<<<....>>>......................... ......(((....)))......................... STRUCTURE OF RIBOSOMAL PROTEINS S15, S6, S18, AND 16S RIBOSOMAL RNA; 16S RIBOSOMAL RNA 1g1x J 44 2.6 URS000080E2CD_32630 10753109 32630 acgccgauggcgaaggcagccaccugguccacccgugacgcuuu .........<<....>>........................... .........((....))........................... STRUCTURE OF RIBOSOMAL PROTEINS S15, S6, S18, AND 16S RIBOSOMAL RNA; 16S RIBOSOMAL RNA 1h1k I 412 10.0 URS000080E18E_40051 12186935,9774103 40051 aaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa ............................................................................................................................................................................................................................................................................................................................................................................................................................ ............................................................................................................................................................................................................................................................................................................................................................................................................................ THE BLUETONGUE VIRUS (BTV) CORE BINDS DSRNA; RNA 1h1k J 276 10.0 URS000080E296_40051 12186935,9774103 40051 aaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa .................................................................................................................................................................................................................................................................................... .................................................................................................................................................................................................................................................................................... THE BLUETONGUE VIRUS (BTV) CORE BINDS DSRNA; RNA 1h1k K 265 10.0 URS000080E17F_40051 12186935,9774103 40051 aaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa ......................................................................................................................................................................................................................................................................... ......................................................................................................................................................................................................................................................................... THE BLUETONGUE VIRUS (BTV) CORE BINDS DSRNA; RNA 1h1k L 412 10.0 URS000080DF28_40051 12186935,9774103 40051 uuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuu ............................................................................................................................................................................................................................................................................................................................................................................................................................ ............................................................................................................................................................................................................................................................................................................................................................................................................................ THE BLUETONGUE VIRUS (BTV) CORE BINDS DSRNA; RNA 1h1k M 276 10.0 URS000080E01E_40051 12186935,9774103 40051 uuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuu .................................................................................................................................................................................................................................................................................... .................................................................................................................................................................................................................................................................................... THE BLUETONGUE VIRUS (BTV) CORE BINDS DSRNA; RNA 1h1k N 265 10.0 URS000080DD80_40051 12186935,9774103 40051 uuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuu ......................................................................................................................................................................................................................................................................... ......................................................................................................................................................................................................................................................................... THE BLUETONGUE VIRUS (BTV) CORE BINDS DSRNA; RNA 1hnw A 1507 3.4 RF00177,RF01959,RF01960 URS000080E226_274 11163189 0003735 0005840 274 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggauca ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<.......>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<<....>>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.....)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((......(.(((....))).).....((.(....).))....))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..((...(((.....)))).)...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... STRUCTURE OF THE THERMUS THERMOPHILUS 30S RIBOSOMAL SUBUNIT IN COMPLEX WITH TETRACYCLINE; 16S RIBOSOMAL RNA 1hnx A 1507 3.4 RF00177,RF01959,RF01960 URS000080E226_274 11163189 0003735 0005840 274 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggauca ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<.......>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<<....>>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.....)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((......(((((....))))).....((.(....).))....))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...(...(((.....)))).....)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... STRUCTURE OF THE THERMUS THERMOPHILUS 30S RIBOSOMAL SUBUNIT IN COMPLEX WITH PACTAMYCIN; 16S RIBOSOMAL RNA 1hnz A 1507 3.3 RF00177,RF01959,RF01960 URS000080E226_274 11163189 0003735 0005840 274 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggauca ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<.......>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<.......<<<<<<<..<<<<<<<....>>>>>>>...<<<<....>>>>..>>>>>>>..<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<...<<<.....>>>.>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<...<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>...>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.....)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((.....)))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((......(.(((....))).).....((((....))))....))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..((...(((.....)))).)...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((.((((((...(.((((....(((....))).)))).)..)))))).))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... STRUCTURE OF THE THERMUS THERMOPHILUS 30S RIBOSOMAL SUBUNIT IN COMPLEX WITH HYGROMYCIN B; 16S RIBOSOMAL RNA 1hr0 A 1507 3.2 RF00177,RF01959,RF01960 URS000080E226_274 11228145 0003735 0005840 274 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggauca ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<.......>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<<....>>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.....)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((......(((((....))))).....((.(....).))....))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..((...(((.....)))).)...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((.((((((...(.((((....(((....))).)))).)..)))))).))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... CRYSTAL STRUCTURE OF INITIATION FACTOR IF1 BOUND TO THE 30S RIBOSOMAL SUBUNIT; 16S RIBOSOMAL RNA 1i2x A 11 2.4 11333021 gcgatatacgu ........... ........... 2.4 A STRUCTURE OF A-DUPLEX WITH BULGED ADENOSINE, SPERMIDINE FORM; DNA/RNA (5'-R(*GP*CP*G)-D(P*AP*TP*AP*T)-R(P*AP*CP*GP*U)-3') 1i2x B 11 2.4 11333021 gcgatatacgu ........... ........... 2.4 A STRUCTURE OF A-DUPLEX WITH BULGED ADENOSINE, SPERMIDINE FORM; DNA/RNA (5'-R(*GP*CP*G)-D(P*AP*TP*AP*T)-R(P*AP*CP*GP*U)-3') 1i2x D 11 2.4 11333021 gcgatatacgu ........... ........... 2.4 A STRUCTURE OF A-DUPLEX WITH BULGED ADENOSINE, SPERMIDINE FORM; DNA/RNA (5'-R(*GP*CP*G)-D(P*AP*TP*AP*T)-R(P*AP*CP*GP*U)-3') 1i2x C 11 2.4 11333021 gcgatatacgu ........... ........... 2.4 A STRUCTURE OF A-DUPLEX WITH BULGED ADENOSINE, SPERMIDINE FORM; DNA/RNA (5'-R(*GP*CP*G)-D(P*AP*TP*AP*T)-R(P*AP*CP*GP*U)-3') 1i2y A 11 1.66 11333021 gcgatatacgu ........... ........... 1.66 A STRUCTURE OF A-DUPLEX WITH BULGED ADENOSINE, SPERMINE FORM; DNA/RNA (5'-R(*GP*CP*G)-D(P*AP*TP*AP*T)-R(P*AP*CP*GP*U)-3') 1i2y B 11 1.66 11333021 gcgatatacgu ........... ........... 1.66 A STRUCTURE OF A-DUPLEX WITH BULGED ADENOSINE, SPERMINE FORM; DNA/RNA (5'-R(*GP*CP*G)-D(P*AP*TP*AP*T)-R(P*AP*CP*GP*U)-3') 1i2y C 11 1.66 11333021 gcgatatacgu ........... ........... 1.66 A STRUCTURE OF A-DUPLEX WITH BULGED ADENOSINE, SPERMINE FORM; DNA/RNA (5'-R(*GP*CP*G)-D(P*AP*TP*AP*T)-R(P*AP*CP*GP*U)-3') 1i2y D 11 1.66 11333021 gcgatatacgu ........... ........... 1.66 A STRUCTURE OF A-DUPLEX WITH BULGED ADENOSINE, SPERMINE FORM; DNA/RNA (5'-R(*GP*CP*G)-D(P*AP*TP*AP*T)-R(P*AP*CP*GP*U)-3') 1i2y E 11 1.66 11333021 gcgatatacgu ........... ........... 1.66 A STRUCTURE OF A-DUPLEX WITH BULGED ADENOSINE, SPERMINE FORM; DNA/RNA (5'-R(*GP*CP*G)-D(P*AP*TP*AP*T)-R(P*AP*CP*GP*U)-3') 1i2y F 11 1.66 11333021 gcgatatacgu ........... ........... 1.66 A STRUCTURE OF A-DUPLEX WITH BULGED ADENOSINE, SPERMINE FORM; DNA/RNA (5'-R(*GP*CP*G)-D(P*AP*TP*AP*T)-R(P*AP*CP*GP*U)-3') 1i9x A 13 2.18 URS000080E04A_32630 11350032 32630 uacuaacguagua ............. ............. CRYSTAL STRUCTURE OF BPS-U2 SNRNA DUPLEX; 5'-R(*UP*AP*CP*UP*AP*AP*CP*GP*UP*AP*GP*UP*A)-3' 1i9x B 13 2.18 URS000080E04A_32630 11350032 32630 uacuaacguagua ............. ............. CRYSTAL STRUCTURE OF BPS-U2 SNRNA DUPLEX; 5'-R(*UP*AP*CP*UP*AP*AP*CP*GP*UP*AP*GP*UP*A)-3' 1ibk A 1506 3.31 RF00177,RF01959,RF01960 URS000080E226_274 11340196 0003735 0005840 274 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggauc ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<.......>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<.......<<<<<<<..<<.<<<<....>>>>>>..<.<<.<....>>>..>>>>>>>>..<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<...<<<.....>>>.>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.....)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(..(.........((((....))))......((.......)).......)..)).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..((...(((.....)))).)...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((.((((((...(.((((....(((....))).)))).)..)))))).))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... STRUCTURE OF THE THERMUS THERMOPHILUS 30S RIBOSOMAL SUBUNIT IN COMPLEX WITH THE ANTIBIOTIC PAROMOMYCIN; 16S RIBOSOMAL RNA 1ibl A 1507 3.11 RF00177,RF01959,RF01960 URS000080E226_274 11340196 0003735 0005840 274 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggauca ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<.......>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<<....>>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.....)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((......((((((....)))))).....(((....)))......)))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...(...(((.....)))).....)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... STRUCTURE OF THE THERMUS THERMOPHILUS 30S RIBOSOMAL SUBUNIT IN COMPLEX WITH A MESSENGER RNA FRAGMENT AND COGNATE TRANSFER RNA ANTICODON STEM-LOOP BOUND AT THE A SITE AND WITH THE ANTIBIOTIC PAROMOMYCIN; 16S RIBOSOMAL RNA 1ibl Y 15 3.11 URS000080E1F5_32630 11340196 32630 gggauugaaaauccc <<<<<.....>>>>> ((((.......)))) STRUCTURE OF THE THERMUS THERMOPHILUS 30S RIBOSOMAL SUBUNIT IN COMPLEX WITH A MESSENGER RNA FRAGMENT AND COGNATE TRANSFER RNA ANTICODON STEM-LOOP BOUND AT THE A SITE AND WITH THE ANTIBIOTIC PAROMOMYCIN; ANTICODON STEM-LOOP OF PHENYLALANINE TRANSFER RNA 1ibm A 1507 3.31 RF00177,RF01959,RF01960 URS000080E226_274 11340196 0003735 0005840 274 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggauca ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<.......>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<.<......>.>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.....)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((......(((.(((....))).))).....................))))).((.(((...((.(((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((.......(((.....)))......)))))))..(..(((((....))))).....)..)))).....).).))....)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... STRUCTURE OF THE THERMUS THERMOPHILUS 30S RIBOSOMAL SUBUNIT IN COMPLEX WITH A MESSENGER RNA FRAGMENT AND COGNATE TRANSFER RNA ANTICODON STEM-LOOP BOUND AT THE A SITE; 16S RIBOSOMAL RNA 1ibm Y 11 3.31 URS000080E1F5_32630 11340196 32630 gauugaaaauc <<<.....>>> ((.......)) STRUCTURE OF THE THERMUS THERMOPHILUS 30S RIBOSOMAL SUBUNIT IN COMPLEX WITH A MESSENGER RNA FRAGMENT AND COGNATE TRANSFER RNA ANTICODON STEM-LOOP BOUND AT THE A SITE; ANTICODON STEM-LOOP OF PHENYLALANINE TRANSFER RNA 1ik5 A 14 1.8 URS000080E241_32630 11680847 32630 gguauuucgguanc .............. .............. Crystal Structure of a 14mer RNA Containing Double UU Bulges in Two Crystal Forms: A Novel U*(AU) Intramolecular Base Triple; 5'-R(*GP*GP*UP*AP*UP*UP*UP*CP*GP*GP*UP*AP*(CBR)P*C)-3' 1ik5 B 14 1.8 URS000080DFEB_32630 11680847 32630 gguauuuugguanc .............. .............. Crystal Structure of a 14mer RNA Containing Double UU Bulges in Two Crystal Forms: A Novel U*(AU) Intramolecular Base Triple; 5'-R(*GP*GP*UP*AP*UP*UP*UP*UP*GP*GP*UP*AP*(CBR)P*C)-3' 1j7t A 21 2.5 URS000080E2C5_32630 11587639 32630 gcgucacaccggugaagucgc ..................... ..................... Complex between Paromomycin and the 16S-rRNA A-site at 2.5 A resolution; 5'-R(*CP*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*C)-3' 1j7t B 21 2.5 URS000080E2C5_32630 11587639 32630 gcgucacaccggugaagucgc ..................... ..................... Complex between Paromomycin and the 16S-rRNA A-site at 2.5 A resolution; 5'-R(*CP*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*C)-3' 1jbr C 18 2.15 URS000080E335_32630 11685244 32630 gcgcuccucaguacgagn .................. .................. Crystal Structure of the Ribotoxin Restrictocin and a 31-mer SRD RNA Inhibitor; 5'-R(*GP*CP*GP*CP*UP*CP*CP*UP*CP*AP*GP*UP*AP*CP*GP*AP*GP*(A23))-3' 1jbr F 13 2.15 URS000080E0E4_32630 11685244 32630 ggaaccggagcgc ............. ............. Crystal Structure of the Ribotoxin Restrictocin and a 31-mer SRD RNA Inhibitor; 5'-R(*GP*GP*AP*AP*CP*CP*GP*GP*AP*GP*CP*GP*C)-3' 1jgo B 76 5.6 RF00005 URS000011107D_32630 11511350 0030533 0006412 32630 gcggauuuancucagnngggagagcnccaganunaagaunuggagnucnugugnucgnuccacagaauucgcacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((.........)))).....(((((..]....)))))))))))).... The Path of Messenger RNA Through the Ribosome. THIS FILE, 1JGO, CONTAINS THE 30S RIBOSOME SUBUNIT, THREE TRNA, AND MRNA MOLECULES. 50S RIBOSOME SUBUNIT IS IN THE FILE 1GIY; tRNA(Phe) 1jgo C 76 5.6 RF00005 URS000011107D_32630 11511350 0030533 0006412 32630 gcggauuuancucagnngggagagcnccaganunaagaunuggagnucnugugnucgnuccacagaauucgcacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... .((((((..((((.....[..)))).((((.........)))).....(((((..]....)))))))))))..... The Path of Messenger RNA Through the Ribosome. THIS FILE, 1JGO, CONTAINS THE 30S RIBOSOME SUBUNIT, THREE TRNA, AND MRNA MOLECULES. 50S RIBOSOME SUBUNIT IS IN THE FILE 1GIY; tRNA(Phe) 1jgo 1 27 5.6 11511350 ggcaaggagguaaaauuuuuuaaaaaa ........................... ........................... The Path of Messenger RNA Through the Ribosome. THIS FILE, 1JGO, CONTAINS THE 30S RIBOSOME SUBUNIT, THREE TRNA, AND MRNA MOLECULES. 50S RIBOSOME SUBUNIT IS IN THE FILE 1GIY; MESSENGER RNA MK27 1jgp B 76 7.0 RF00005 URS000011107D_32630 11511350 0030533 0006412 32630 gcggauuuancucagnngggagagcnccaganunaagaunuggagnucnugugnucgnuccacagaauucgcacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((.........)))).....(((((..]....)))))))))))).... The Path of Messenger RNA Through the Ribosome. THIS FILE, 1JGP, CONTAINS THE 30S RIBOSOME SUBUNIT, THREE TRNA, AND MRNA MOLECULES. 50S RIBOSOME SUBUNIT IS IN THE FILE 1GIY; tRNA(Phe) 1jgp C 76 7.0 RF00005 URS000011107D_32630 11511350 0030533 0006412 32630 gcggauuuancucagnngggagagcnccaganunaagaunuggagnucnugugnucgnuccacagaauucgcacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... .((((((..((((.....[..)))).((((.........)))).....(((((..]....)))))))))))..... The Path of Messenger RNA Through the Ribosome. THIS FILE, 1JGP, CONTAINS THE 30S RIBOSOME SUBUNIT, THREE TRNA, AND MRNA MOLECULES. 50S RIBOSOME SUBUNIT IS IN THE FILE 1GIY; tRNA(Phe) 1jgp 1 32 7.0 11511350 ggcaaggagguaaaauuuuuuaaacguaaauc ................................ ................................ The Path of Messenger RNA Through the Ribosome. THIS FILE, 1JGP, CONTAINS THE 30S RIBOSOME SUBUNIT, THREE TRNA, AND MRNA MOLECULES. 50S RIBOSOME SUBUNIT IS IN THE FILE 1GIY; MESSENGER RNA MV36 1jgq B 76 5.0 RF00005 URS000011107D_32630 11511350 0030533 0006412 32630 gcggauuuancucagnngggagagcnccaganunaagaunuggagnucnugugnucgnuccacagaauucgcacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((.........)))).....(((((..]....)))))))))))).... The Path of Messenger RNA Through the Ribosome. THIS FILE, 1JGQ, CONTAINS THE 30S RIBOSOME SUBUNIT, THREE TRNA, AND MRNA MOLECULES. 50S RIBOSOME SUBUNIT IS IN THE FILE 1GIY; tRNA(Phe) 1jgq C 76 5.0 RF00005 URS000011107D_32630 11511350 0030533 0006412 32630 gcggauuuancucagnngggagagcnccaganunaagaunuggagnucnugugnucgnuccacagaauucgcacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... .((((((..((((.....[..)))).((((.........)))).....(((((..]....)))))))))))..... The Path of Messenger RNA Through the Ribosome. THIS FILE, 1JGQ, CONTAINS THE 30S RIBOSOME SUBUNIT, THREE TRNA, AND MRNA MOLECULES. 50S RIBOSOME SUBUNIT IS IN THE FILE 1GIY; tRNA(Phe) 1jgq 1 36 5.0 11511350 ggcaaggagguaaaauuuuuuaaacguaaaucuacu ..................<<<<....>>>>...... ..................(((......)))...... The Path of Messenger RNA Through the Ribosome. THIS FILE, 1JGQ, CONTAINS THE 30S RIBOSOME SUBUNIT, THREE TRNA, AND MRNA MOLECULES. 50S RIBOSOME SUBUNIT IS IN THE FILE 1GIY; MESSENGER RNA MF36 1jj2 0 2754 2.4 RF02540,RF00002 URS000080DFCD_2238 11483524 0003735 0005840 2238 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...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......(..(.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......)..)...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((..((....(....(((((....))))).....)...))..))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Fully Refined Crystal Structure of the Haloarcula marismortui Large Ribosomal Subunit at 2.4 Angstrom Resolution; 23S RRNA 1jj2 9 122 2.4 RF00001 URS00003592C7_2238 11483524 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccggggaguacuggagugcgcgagccucugggaaacccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<<<<.....<<<<<<.<<....>>>>>>>>....>>>>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...(((((.....((((((.((....))))))))....)))))...))))))... Fully Refined Crystal Structure of the Haloarcula marismortui Large Ribosomal Subunit at 2.4 Angstrom Resolution; 5S RRNA 1ju1 A 23 NA URS000080DD3F_32630 10447199 32630 cuugcugaagcgcgcacggcaag ....................... ....................... Dimer Initiation Sequence of HIV-1Lai Genomic RNA: NMR Solution Structure of the Extended Duplex; HIV-1Lai SL1 1ju1 B 23 NA URS000080DD3F_32630 10447199 32630 cuugcugaagcgcgcacggcaag ....................... ....................... Dimer Initiation Sequence of HIV-1Lai Genomic RNA: NMR Solution Structure of the Extended Duplex; HIV-1Lai SL1 1k73 A 2754 3.01 RF02540,RF00002 URS000080DFCD_2238 12860128 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagccauggggagccgcacggaggcgaagaaccauggauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaaugugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucucgacgaagucucuuggaacagagcgugauacagggugacaaccccguacucgagaccaguacgacgugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccucgacgaaugaccgacgcgcgagcguccaguaagacucacgggaagccgauguucugucguacguuuugaaaaacgagccagggagugugucugcauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgccguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaaguaggggugaaaacuccuauggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucauaccgcaacucgacuaugacgaaaugggaaacggguuaauauucccgugccacuaugcagugaaaguugacgcccuggggucgaucacgcugggcaucgcccagucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcauaguguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcgaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggcuaucucagccggggacccggcgaagagugcaagagcaaaagauagcuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugagguuguucgccuauuaaaggaggucgugagcuggguuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>...<<<<<.....<<.....>>....>>>>>...<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<..<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>..>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<..<<.........<<<<<....>>>>>.........>>..>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<...<<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>>.<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<.<<<.....>>>.>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<<...<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>.>>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......(..(.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......)..)...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((..((....(....(((((....))))).....)...))..))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Co-crystal Structure of Anisomycin Bound to the 50S Ribosomal Subunit; 23S RRNA 1k73 B 122 3.01 RF00001 URS00003592C7_2238 12860128 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccggggaguacuggagugcgcgagccucugggaaacccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<<<<.....<<<<<<.<<....>>>>>>>>....>>>>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...(((((.....((((((.((....))))))))....)))))...))))))... Co-crystal Structure of Anisomycin Bound to the 50S Ribosomal Subunit; 5S RRNA 1k8a A 2754 3.0 RF02540,RF00002 URS000080DFCD_2238 12150912 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagccauggggagccgcacggaggcgaagaaccauggauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaaugugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucucgacgaagucucuuggaacagagcgugauacagggugacaaccccguacucgagaccaguacgacgugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccucgacgaaugaccgacgcgcgagcguccaguaagacucacgggaagccgauguucugucguacguuuugaaaaacgagccagggagugugucugcauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgccguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaaguaggggugaaaacuccuauggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucauaccgcaacucgacuaugacgaaaugggaaacggguuaauauucccgugccacuaugcagugaaaguugacgcccuggggucgaucacgcugggcaucgcccagucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcauaguguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcgaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggcuaucucagccggggacccggcgaagagugcaagagcaaaagauagcuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugagguuguucgccuauuaaaggaggucgugagcuggguuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>..<<<<<<.....<<.....>>....>>>>>>..<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<..<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>..>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<..<<.........<<<<<....>>>>>.........>>..>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<...<<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>>.<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<<<<<.....>>>>>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<<...<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>.>>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......(..(.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......)..)...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((..((....(....(((((....))))).....)...))..))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Co-crystal structure of Carbomycin A bound to the 50S ribosomal subunit of Haloarcula marismortui; 23S RRNA 1k8a B 122 3.0 RF00001 URS00003592C7_2238 12150912 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccggggaguacuggagugcgcgagccucugggaaacccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<<<<.....<<<<<<.<<....>>>>>>>>....>>>>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...(((((.....((((((.((....))))))))....)))))...))))))... Co-crystal structure of Carbomycin A bound to the 50S ribosomal subunit of Haloarcula marismortui; 5S RRNA 1k8s A 13 NA URS000080E270_32630 10903860 32630 ggcagagugccgc ............. ............. BULGED ADENOSINE IN AN RNA DUPLEX; 5'-R(*GP*GP*CP*AP*GP*AP*GP*UP*GP*CP*CP*GP*C)-3' 1k8s B 12 NA URS000080DDAD_32630 10903860 32630 gcggcaccugcc ............ ............ BULGED ADENOSINE IN AN RNA DUPLEX; 5'-R(*GP*CP*GP*GP*CP*AP*CP*CP*UP*GP*CP*C)-3' 1k9m A 2754 3.0 RF02540,RF00002 URS000080DFCD_2238 12150912 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagccauggggagccgcacggaggcgaagaaccauggauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaaugugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucucgacgaagucucuuggaacagagcgugauacagggugacaaccccguacucgagaccaguacgacgugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccucgacgaaugaccgacgcgcgagcguccaguaagacucacgggaagccgauguucugucguacguuuugaaaaacgagccagggagugugucugcauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgccguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaaguaggggugaaaacuccuauggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucauaccgcaacucgacuaugacgaaaugggaaacggguuaauauucccgugccacuaugcagugaaaguugacgcccuggggucgaucacgcugggcaucgcccagucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcauaguguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcgaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggcuaucucagccggggacccggcgaagagugcaagagcaaaagauagcuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugagguuguucgccuauuaaaggaggucgugagcuggguuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>...<<<<<.....<<.....>>....>>>>>...<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<..<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>..>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<..<<.........<<<<<....>>>>>.........>>..>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<...<<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>>.<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<.<<<.....>>>.>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<<...<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>.>>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......(..(.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......)..)...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((..((....(....(((((....))))).....)...))..))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Co-crystal structure of tylosin bound to the 50S ribosomal subunit of Haloarcula marismortui; 23S RRNA 1k9m B 122 3.0 RF00001 URS00003592C7_2238 12150912 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccggggaguacuggagugcgcgagccucugggaaacccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<<<<.....<<<<<<.<<....>>>>>>>>....>>>>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...(((((.....((((((.((....))))))))....)))))...))))))... Co-crystal structure of tylosin bound to the 50S ribosomal subunit of Haloarcula marismortui; 5S RRNA 1k9w A 23 3.1 URS000080DFB5_32630 11702070 32630 uuugcugaggugcacacagcaau .<<<<<<.........>>>>>>. ...((((.........))))... HIV-1(MAL) RNA Dimerization Initiation Site; HIV-1 DIS(Mal)UU RNA 1k9w B 23 3.1 URS000080DFB5_32630 11702070 32630 uuugcugaggugcacacagcaau .<<<<<<.........>>>>>>. .((((((.........)))))). HIV-1(MAL) RNA Dimerization Initiation Site; HIV-1 DIS(Mal)UU RNA 1k9w C 23 3.1 URS000080DFB5_32630 11702070 32630 uuugcugaggugcacacagcaau .<<<<<<.........>>>>>>. ...((((.........))))... HIV-1(MAL) RNA Dimerization Initiation Site; HIV-1 DIS(Mal)UU RNA 1k9w D 23 3.1 URS000080DFB5_32630 11702070 32630 uuugcugaggugcacacagcaau .<<<<<<.........>>>>>>. .((((((.........)))))). HIV-1(MAL) RNA Dimerization Initiation Site; HIV-1 DIS(Mal)UU RNA 1kc8 A 2754 3.01 RF02540,RF00002 URS000080DFCD_2238 12860128 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagccauggggagccgcacggaggcgaagaaccauggauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaaugugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucucgacgaagucucuuggaacagagcgugauacagggugacaaccccguacucgagaccaguacgacgugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccucgacgaaugaccgacgcgcgagcguccaguaagacucacgggaagccgauguucugucguacguuuugaaaaacgagccagggagugugucugcauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgccguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaaguaggggugaaaacuccuauggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucauaccgcaacucgacuaugacgaaaugggaaacggguuaauauucccgugccacuaugcagugaaaguugacgcccuggggucgaucacgcugggcaucgcccagucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcauaguguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcgaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggcuaucucagccggggacccggcgaagagugcaagagcaaaagauagcuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugagguuguucgccuauuaaaggaggucgugagcuggguuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>...<<<<<.....<<.....>>....>>>>>...<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<..<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>..>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<..<<.........<<<<<....>>>>>.........>>..>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<...<<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>>.<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<<<<<.....>>>>>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<<...<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>.>>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......(..(.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......)..)...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((..((....(....(((((....))))).....)...))..))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Co-crystal Structure of Blasticidin S Bound to the 50S Ribosomal Subunit; 23S RRNA 1kc8 B 122 3.01 RF00001 URS00003592C7_2238 12860128 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccggggaguacuggagugcgcgagccucugggaaacccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<<<<.....<<<<<<.<<....>>>>>>>>....>>>>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...(((((.....((((((.((....))))))))....)))))...))))))... Co-crystal Structure of Blasticidin S Bound to the 50S Ribosomal Subunit; 5S RRNA 1kd1 A 2754 3.0 RF02540,RF00002 URS000080DFCD_2238 12150912 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagccauggggagccgcacggaggcgaagaaccauggauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaaugugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucucgacgaagucucuuggaacagagcgugauacagggugacaaccccguacucgagaccaguacgacgugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccucgacgaaugaccgacgcgcgagcguccaguaagacucacgggaagccgauguucugucguacguuuugaaaaacgagccagggagugugucugcauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgccguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaaguaggggugaaaacuccuauggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucauaccgcaacucgacuaugacgaaaugggaaacggguuaauauucccgugccacuaugcagugaaaguugacgcccuggggucgaucacgcugggcaucgcccagucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcauaguguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcgaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggcuaucucagccggggacccggcgaagagugcaagagcaaaagauagcuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugagguuguucgccuauuaaaggaggucgugagcuggguuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>...<<<<<.....<<.....>>....>>>>>...<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<..<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>..>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<..<<.........<<<<<....>>>>>.........>>..>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<.<<<.....>>>.>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<<...<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>.>>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......(..(.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......)..)...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((..((....(....(((((....))))).....)...))..))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Co-crystal Structure of Spiramycin bound to the 50S Ribosomal Subunit of Haloarcula marismortui; 23S RRNA 1kd1 B 122 3.0 RF00001 URS00003592C7_2238 12150912 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccggggaguacuggagugcgcgagccucugggaaacccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<<<<.....<<<<<<.<<....>>>>>>>>....>>>>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...(((((.....((((((.((....))))))))....)))))...))))))... Co-crystal Structure of Spiramycin bound to the 50S Ribosomal Subunit of Haloarcula marismortui; 5S RRNA 1kd3 A 11 1.8 URS000080E064_32630 12595698 32630 ggucacagccc ........... ........... The Crystal Structure of r(GGUCACAGCCC)2, Thallium form; 5'-R(*GP*GP*UP*CP*AP*CP*AP*GP*CP*CP*C)-3' 1kd3 B 11 1.8 URS000080E064_32630 12595698 32630 ggucacagccc ........... ........... The Crystal Structure of r(GGUCACAGCCC)2, Thallium form; 5'-R(*GP*GP*UP*CP*AP*CP*AP*GP*CP*CP*C)-3' 1kd4 A 11 1.85 URS000080E064_32630 12595698 32630 ggucacagccc ........... ........... The Crystal Structure of r(GGUCACAGCCC)2, Barium form; 5'-R(*GP*GP*UP*CP*AP*CP*AP*GP*CP*CP*C)-3' 1kd4 B 11 1.85 URS000080E064_32630 12595698 32630 ggucacagccc ........... ........... The Crystal Structure of r(GGUCACAGCCC)2, Barium form; 5'-R(*GP*GP*UP*CP*AP*CP*AP*GP*CP*CP*C)-3' 1kd5 A 11 1.58 URS000080E064_32630 12595698 32630 ggucacagccc ........... ........... The Crystal Structure of r(GGUCACAGCCC)2 metal free form; 5'-R(*GP*GP*UP*CP*AP*CP*AP*GP*CP*CP*C)-3' 1kd5 B 11 1.58 URS000080E064_32630 12595698 32630 ggucacagccc ........... ........... The Crystal Structure of r(GGUCACAGCCC)2 metal free form; 5'-R(*GP*GP*UP*CP*AP*CP*AP*GP*CP*CP*C)-3' 1kfo A 19 1.6 URS000080DD52_32630 12166647 32630 gaaugccugcgagcanccc ................... ................... CRYSTAL STRUCTURE OF AN RNA HELIX RECOGNIZED BY A ZINC-FINGER PROTEIN: AN 18 BASE PAIR DUPLEX AT 1.6 RESOLUTION; 5'-R(*GP*AP*AP*UP*GP*CP*CP*UP*GP*CP*GP*AP*GP*CP*AP*(5BU)P*CP*CP*C)-3' 1kis A 16 NA URS000080E1E1_32630 9193000 32630 gagcccugggaggcuc <<<<<......>>>>> (((((......))))) TAR-TAR ""KISSING"" HAIRPIN COMPLEX DERIVED FROM THE HIV GENOME, NMR, 1 STRUCTURE; RNA (5'-R(*GP*AP*GP*CP*CP*CP*UP*GP*GP*GP*AP*GP*GP*CP*UP*C)-3') 1kis B 16 NA URS000080DEAF_32630 9193000 32630 gcuguucccagacagc <<<<<......>>>>> (((((......))))) TAR-TAR ""KISSING"" HAIRPIN COMPLEX DERIVED FROM THE HIV GENOME, NMR, 1 STRUCTURE; RNA (5'-R(*GP*CP*UP*GP*UP*UP*CP*CP*CP*AP*GP*AP*CP*AP*GP*C)-3') 1koc A 11 NA URS000080E0C2_32630 8650546 32630 agaaggagcgu ........... ........... RNA APTAMER COMPLEXED WITH ARGININE, NMR; RNA (5'-R(P*AP*GP*AP*AP*GP*GP*AP*GP*CP*GP*U)-3') 1koc B 14 NA URS000080E291_32630 8650546 32630 acagguaggucgcu .............. .............. RNA APTAMER COMPLEXED WITH ARGININE, NMR; RNA (5'-R(P*AP*CP*AP*GP*GP*UP*AP*GP*GP*UP*CP*GP*CP*U)-3') 1kod A 11 NA URS000080E00C_32630 8650546 32630 agaaggagugu ........... ........... RNA APTAMER COMPLEXED WITH CITRULLINE, NMR; RNA (5'-R(P*AP*GP*AP*AP*GP*GP*AP*GP*UP*GP*U)-3') 1kod B 14 NA URS000080E278_32630 8650546 32630 acgguuaggucgcu .............. .............. RNA APTAMER COMPLEXED WITH CITRULLINE, NMR; RNA (5'-R(P*AP*CP*GP*GP*UP*UP*AP*GP*GP*UP*CP*GP*CP*U)-3') 1kqs 0 2754 3.1 RF02540,RF00002 URS000080DFCD_2238 11828326 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagccauggggagccgcacggaggcgaagaaccauggauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaaugugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucucgacgaagucucuuggaacagagcgugauacagggugacaaccccguacucgagaccaguacgacgugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccucgacgaaugaccgacgcgcgagcguccaguaagacucacgggaagccgauguucugucguacguuuugaaaaacgagccagggagugugucugcauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgccguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaaguaggggugaaaacuccuauggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucauaccgcaacucgacuaugacgaaaugggaaacggguuaauauucccgugccacuaugcagugaaaguugacgcccuggggucgaucacgcugggcaucgcccagucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcauaguguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcgaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggcuaucucagccggggacccggcgaagagugcaagagcaaaagauagcuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugagguuguucgccuauuaaaggaggucgugagcuggguuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa 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...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......(..(.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......)..)...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((..((....(....(((((....))))).....)...))..))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. The Haloarcula marismortui 50S Complexed with a Pretranslocational Intermediate in Protein Synthesis; 23S RRNA 1kqs 9 122 3.1 RF00001 URS00003592C7_2238 11828326 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccggggaguacuggagugcgcgagccucugggaaacccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<<<<.....<<<<<<.<<....>>>>>>>>....>>>>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...(((((.....((((((.((....))))))))....)))))...))))))... The Haloarcula marismortui 50S Complexed with a Pretranslocational Intermediate in Protein Synthesis; 5S RRNA 1lc4 A 21 2.54 URS000080E29E_32630 12079787 32630 gcgucacaccggugaagucgc ..................... ..................... Crystal Structure of Tobramycin Bound to the Eubacterial 16S rRNA A Site; 5'-R(*UP*UP*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*C)-3' 1lc4 B 21 2.54 URS000080E29E_32630 12079787 32630 gcgucacaccggugaagucgc ..................... ..................... Crystal Structure of Tobramycin Bound to the Eubacterial 16S rRNA A Site; 5'-R(*UP*UP*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*C)-3' 1lmv B 10 NA URS000080E2FE_4932 12426583 4932 uacuaacacc .......... .......... Solution structure of the unmodified U2 snRNA-intron branch site helix from S. cerevisiae; 5'-R(*UP*AP*CP*UP*AP*AP*CP*AP*CP*C)-3' 1lnt A 12 1.7 URS000080E184_32630 12777762 32630 gcgucaggucng ............ ............ Crystal Structure of the Highly Conserved RNA Internal Loop of SRP; 5'-R(*GP*CP*GP*UP*CP*AP*GP*GP*UP*CP*(CBV)P*G)-3' 1lnt B 12 1.7 URS000080DF26_32630 12777762 32630 cggaagcagngc ............ ............ Crystal Structure of the Highly Conserved RNA Internal Loop of SRP; 5'-R(*CP*GP*GP*AP*AP*GP*CP*AP*GP*(CBV)P*GP*C)-3' 1lpw B 10 NA URS000080E2FE_4932 12426583 4932 uacuaacacc .......... .......... Solution structure of the yeast spliceosomal U2 snRNA-intron branch site helix featuring a conserved pseudouridine; 5'-R(*UP*AP*CP*UP*AP*AP*CP*AP*CP*C)-3' 1m1k A 2754 3.2 RF02540,RF00002 URS000080DFCD_2238 12150912 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagccauggggagccgcacggaggcgaagaaccauggauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaaugugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucucgacgaagucucuuggaacagagcgugauacagggugacaaccccguacucgagaccaguacgacgugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccucgacgaaugaccgacgcgcgagcguccaguaagacucacgggaagccgauguucugucguacguuuugaaaaacgagccagggagugugucugcauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgccguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaaguaggggugaaaacuccuauggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucauaccgcaacucgacuaugacgaaaugggaaacggguuaauauucccgugccacuaugcagugaaaguugacgcccuggggucgaucacgcugggcaucgcccagucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcauaguguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcgaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggcuaucucagccggggacccggcgaagagugcaagagcaaaagauagcuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugagguuguucgccuauuaaaggaggucgugagcuggguuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>...<<<<<.....<<.....>>....>>>>>...<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<..<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>..>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<..<<.........<<<<<....>>>>>.........>>..>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<.<<<.....>>>.>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<<...<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>.>>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......(..(.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......)..)...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((..((....(....(((((....))))).....)...))..))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...(((((((((((((.{{)))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Co-crystal structure of azithromycin bound to the 50S ribosomal subunit of Haloarcula marismortui; 23S RRNA 1m1k B 122 3.2 RF00001 URS00003592C7_2238 12150912 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccggggaguacuggagugcgcgagccucugggaaacccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<<<<.....<<<<<<.<<....>>>>>>>>....>>>>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...(((((.....((((((.((....))))))))....)))))...))))))... Co-crystal structure of azithromycin bound to the 50S ribosomal subunit of Haloarcula marismortui; 5S RRNA 1m5k A 21 2.4 URS000080E1CE_32630 11298439 32630 ggccaccugacnguccucucc ..................... ..................... Crystal structure of a hairpin ribozyme in the catalytically-active conformation; RNA INHIBITOR SUBSTRATE 1m5k B 92 2.4 RF04190 URS000080E2EB_32630 11298439 3.1.-.- 0004540 32630 ngagagagaagucaaccagagaaacacaccaacccauugcacuccggguuggugguauauuaccugguacgggggaaacuucgugguggccg ..............<<<<<...<<..<<<<<<<<<..........>>>>>>>>>.....>>..>>>>><<<<<......>>>>>........ ..............(((((...(...(((((((((..........)))))))))......)..)))))(((..........)))........ Crystal structure of a hairpin ribozyme in the catalytically-active conformation; RNA HAIRPIN RIBOZYME 1m5k D 21 2.4 URS000080E1CE_32630 11298439 32630 ggccaccugacnguccucucc ..................... ..................... Crystal structure of a hairpin ribozyme in the catalytically-active conformation; RNA INHIBITOR SUBSTRATE 1m5k E 92 2.4 RF04190 URS000080E2EB_32630 11298439 3.1.-.- 0004540 32630 ngagagagaagucaaccagagaaacacaccaacccauugcacuccggguuggugguauauuaccugguacgggggaaacuucgugguggccg ..............<<<<<....<..<<<<<<<<<..........>>>>>>>>>.....>...>>>>><<<<<<....>>>>>>........ ..............(((((...(...(((((((((..........)))))))))......)..)))))((((((....))))))........ Crystal structure of a hairpin ribozyme in the catalytically-active conformation; RNA HAIRPIN RIBOZYME 1m5o A 21 2.2 URS000080E1CE_32630 12376595 32630 ggccaccugacnguccucucc ..................... ..................... Transition State Stabilization by a Catalytic RNA; RNA SUBSTRATE 1m5o B 92 2.2 RF04190 URS000080E2EB_32630 12376595 3.1.-.- 0004540 32630 ggagagagaagucaaccagagaaacacaccaacccauugcacuccggguuggugguauauuaccugguacgggggaaacuucgugguggccg ..............<<<<<...<<..<<<<<<<<<..........>>>>>>>>>.....>>..>>>>><<<<<<....>>>>>>........ ..............(((((...(...(((((((((..........)))))))))......)..)))))((((.(....).))))........ Transition State Stabilization by a Catalytic RNA; RNA HAIRPIN RIBOZYME 1m5o D 21 2.2 URS000080E1CE_32630 12376595 32630 ggccaccugacnguccucucc ..................... ..................... Transition State Stabilization by a Catalytic RNA; RNA SUBSTRATE 1m5o E 92 2.2 RF04190 URS000080E2EB_32630 12376595 3.1.-.- 0004540 32630 ggagagagaagucaaccagagaaacacaccaacccauugcacuccggguuggugguauauuaccugguacgggggaaacuucgugguggccg ..............<<<<<...<<..<<<<<<<<<..........>>>>>>>>>.....>>..>>>>><<<<<......>>>>>........ ..............(((((...(...(((((((((..........)))))))))......)..)))))((((((....))))))........ Transition State Stabilization by a Catalytic RNA; RNA HAIRPIN RIBOZYME 1m5p A 12 2.6 URS000080DFCC_32630 12376595 32630 ggccaccugaca ............ ............ Transition State Stabilization by a Catalytic RNA; RNA INHIBITOR SUBSTRATE 1m5p B 92 2.6 RF04190 URS000080E2EB_32630 12376595 3.1.-.- 0004540 32630 ggagagagaagucaaccagagaaacacaccaacccauugcacuccggguuggugguauauuaccugguacgggggaaacuucgugguggccg ..............<<<<<...<<..<<<<<<<<<..........>>>>>>>>>.....>>..>>>>><<<<<<....>>>>>>........ ..............(((((...(...(((((((((..........)))))))))......)..)))))((((........))))........ Transition State Stabilization by a Catalytic RNA; RNA HAIRPIN RIBOZYME 1m5p D 12 2.6 URS000080DFCC_32630 12376595 32630 ggccaccugaca ............ ............ Transition State Stabilization by a Catalytic RNA; RNA INHIBITOR SUBSTRATE 1m5p E 92 2.6 RF04190 URS000080E2EB_32630 12376595 3.1.-.- 0004540 32630 ggagagagaagucaaccagagaaacacaccaacccauugcacuccggguuggugguauauuaccugguacgggggaaacuucgugguggccg ..............<<<<<...<<..<<<<<<<<<..........>>>>>>>>>.....>>..>>>>><<<<<<....>>>>>>........ ..............(((((...(...(((((((((..........)))))))))......)..)))))(((.((....)).)))........ Transition State Stabilization by a Catalytic RNA; RNA HAIRPIN RIBOZYME 1m5v A 12 2.4 URS000080DFCC_32630 12376595 32630 ggccaccugacn ............ ............ Transition State Stabilization by a Catalytic RNA; RNA INHIBITOR SUBSTRATE 1m5v B 92 2.4 RF04190 URS000080E2EB_32630 12376595 3.1.-.- 0004540 32630 ggagagagaagucaaccagagaaacacaccaacccauugcacuccggguuggugguauauuaccugguacgggggaaacuucgugguggccg ..............<<<<<...<<..<<<<<<<<<..........>>>>>>>>>.....>>..>>>>><<<<<<....>>>>>>........ ..............(((((...(...(((((((((..........)))))))))......)..)))))((((........))))........ Transition State Stabilization by a Catalytic RNA; RNA HAIRPIN RIBOZYME 1m5v D 12 2.4 URS000080DFCC_32630 12376595 32630 ggccaccugacn ............ ............ Transition State Stabilization by a Catalytic RNA; RNA INHIBITOR SUBSTRATE 1m5v E 92 2.4 RF04190 URS000080E2EB_32630 12376595 3.1.-.- 0004540 32630 ggagagagaagucaaccagagaaacacaccaacccauugcacuccggguuggugguauauuaccugguacgggggaaacuucgugguggccg ..............<<<<<...<<..<<<<<<<<<..........>>>>>>>>>.....>>..>>>>><<<<<......>>>>>........ ..............(((((...(...(((((((((..........)))))))))......)..)))))((((........))))........ Transition State Stabilization by a Catalytic RNA; RNA HAIRPIN RIBOZYME 1m90 A 2754 2.8 RF02540,RF00002 URS000080DFCD_2238 12185246 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagccauggggagccgcacggaggcgaagaaccauggauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaaugugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucucgacgaagucucuuggaacagagcgugauacagggugacaaccccguacucgagaccaguacgacgugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccucgacgaaugaccgacgcgcgagcguccaguaagacucacgggaagccgauguucugucguacguuuugaaaaacgagccagggagugugucugcauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgccguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaaguaggggugaaaacuccuauggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucauaccgcaacucgacuaugacgaaaugggaaacggguuaauauucccgugccacuaugcagugaaaguugacgcccuggggucgaucacgcugggcaucgcccagucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcauaguguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcgaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggcuaucucagccggggacccggcgaagagugcaagagcaaaagauagcuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugagguuguucgccuauuaaaggaggucgugagcuggguuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>...<<<<<.....<<.....>>....>>>>>...<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<..<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>..>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<..<<.........<<<<<....>>>>>.........>>..>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<.<<<.....>>>.>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<....<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>..>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......(..(.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......)..)...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((..((....(....(((((....))))).....)...))..))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Co-crystal structure of CCA-Phe-caproic acid-biotin and sparsomycin bound to the 50S ribosomal subunit; 23S RRNA 1m90 B 122 2.8 RF00001 URS00003592C7_2238 12185246 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccggggaguacuggagugcgcgagccucugggaaacccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<<<<.....<<<<<<.<<....>>>>>>>>....>>>>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...(((((.....((((((.((....))))))))....)))))...))))))... Co-crystal structure of CCA-Phe-caproic acid-biotin and sparsomycin bound to the 50S ribosomal subunit; 5S RRNA 1mhk S 12 2.5 URS000080E004_32630 12554875 32630 ccaugcgaaccg ............ ............ Crystal Structure Analysis of a 26mer RNA molecule, representing a new RNA motif, the hook-turn; RNA 12-mer BCh12 1mhk L 14 2.5 URS000080DEAA_32630 12554875 32630 cgauccuagugugg .............. .............. Crystal Structure Analysis of a 26mer RNA molecule, representing a new RNA motif, the hook-turn; RNA 14-mer BCh12 1mj1 C 76 13.0 RF00005 URS000011107D_562 12379845 0030533 0006412 562 gcggauuuancucagnngggagagcnccaganunaagaunuggagnucnugugnucgnuccacagaauucgcacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... .((((((..((((.....[..)))).((((.........)))).....(((((..]....)))))))))))..... FITTING THE TERNARY COMPLEX OF EF-Tu/tRNA/GTP AND RIBOSOMAL PROTEINS INTO A 13 A CRYO-EM MAP OF THE COLI 70S RIBOSOME; Phe-tRNA 1mj1 R 27 13.0 URS000080DD40_562 12379845 562 gcggccguaacuauaacgguccuaagg ..(<<<..........)>>>.<....> ........................... FITTING THE TERNARY COMPLEX OF EF-Tu/tRNA/GTP AND RIBOSOMAL PROTEINS INTO A 13 A CRYO-EM MAP OF THE COLI 70S RIBOSOME; helix 69 of 23S rRNA 1mji C 34 2.5 URS000080E085_562 12515387 562 ggcaccugaccccaugccgaacucagaagugccc <<<<<<<<...............>>>..>>>>>. (((((((((...(.....)...))))..))))). DETAILED ANALYSIS OF RNA-PROTEIN INTERACTIONS WITHIN THE BACTERIAL RIBOSOMAL PROTEIN L5/5S RRNA COMPLEX; 5S rRNA fragment 1mji D 34 2.5 URS000080E085_562 12515387 562 ggcaccugaccccaugccgaacucagaagugccc <<<<<<<<<.............>>>>..>>>>>. (((((((((...(.....)...))))..))))). DETAILED ANALYSIS OF RNA-PROTEIN INTERACTIONS WITHIN THE BACTERIAL RIBOSOMAL PROTEIN L5/5S RRNA COMPLEX; 5S rRNA fragment 1ml5 B 76 14.0 RF00005 URS000011107D_562 12511961 0030533 0006412 562 gcggauuuancucagnngggagagcnccaganunaagaunuggagnucnugugnucgnuccacagaauucgcacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... .((((((..((((.....[..)))).((((.........)))).....(((((..]....)))))))))))..... Structure of the E. coli ribosomal termination complex with release factor 2; T-RNA(PHE) 1ml5 a 2889 14.0 RF02540,RF02541,RF00002 URS000080E1D6_562 12511961 0003735 0005840 562 ggucaagaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaugcggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgaggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucuugacc <...<<<<.......<<<<<<<<<<...[<<<..<<<<<<<.<<....<..[<<<<<<.{...((]>>>.....<<<<<<....<<))}....>>.......>>>>>>...>>>....<<.....>.><<<<<<<<.{..>>>>>>>>.<<<<<......>>>>>......(<<<<<<..[.<.....[>>.....>>>>>.>)....{...<.....>....<<<<<..........].].....>>>>>...<<<<..<<<<<<<<<.....>>>>>>>>......<<<.<<<..........<.<<<(..<<<(.<<.....<<<<......>>>>.........<<<.......>>>..).>>....>>>..>).>>>......>>>..>>>...>.<<<<<...<.......>}..>>>>>......<<<(......>.)>>..>>>>......>>{.>>>>>.>>....<...]>.....<<.<..>>....>>>........<<<.....>>>...................>>>>>>>>>>.........<<<<<<<<<<.<..>>>>>>>>>>....<..............><<<<<<...<<<<<<<<<<<<...<<<...<<<.....>>>..>>.>.............<<<<.....>>>>......>>>>>>>>>>>>..<<.<...<<<<<.....<<<<<<<<<<..<<.<...<<<<<<......>>>>>>....>.>>...<<<<(<<...........>.>>>>>....>>>>>>>>>><.<<....)..>>...>...>>>>>.}....>.>>...<<<<<....<<<<<....>>>>>.<{<<<<<<.....<<<<<<<<<...<<......<.<.......<<<<<......>>>..>>....((>.>.....>>....>>>>>>>>>.....>>>>>>>.....<<<<<<<.<......<<>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((...{.<<<<<<.....)..<..<<.<<<<<<<<<<......<.<<<<<.<<...<<<<.....(.>>>>...>>.....<...<<......>>>).>>>>>.>..>>>>>>>>>>>>........[[.))..}.>..>>>>>>.>>>...>>>>>>>.<(.<<<......>>>.>)}.....>>>>>....(([....(........<<<<>........>>...>>.....)...)])........>>>>>><<...<..<<.....<<<<<<..(...(>>>>>><<<.....<<<[<.<<....<<<<<<..<<)....>>>>>>>>......(<<<..<<<..<<<...<<<....>>>...>>>..>>>[...<<<<........>>>>{).<<<<<<<<<<.<<...<<<<([..<<<<<....<.<<<<<...<<.<...........>>>..<<....<<..<<<..<<<<<.<.<.....).>>]>>>>>......>]>>>>.....>>}...<<<..)..]>>>......>>>>>>.......>>>>>.........>>>.>..>>....>>>>>>>>>>}>>>..>>......<...>..>.>.>>>..<<<......>>>....>>>..<<<<....<<<<<<<..<<.......(....<...<<<<.....<....(.>..>>>><<<<<<<<<<<........>>>.>>>>>>>.>{.>.......<<<<<<<<<.)<......{......>.(<<[<<.<....<<<<....>>>....>.)>]>>.>>.<<<<<<.....<<<<.<<..<<<...<<[..<<<.......>>>....>>...>>>>>>.>..>>...(<<<..........)>>>.........<<..........<<<<<<)....>>>>>>..>>..>...>>>>>..>>.>>>>>>>.....>>..>>>>>>>.>>>>>>....>>>.(..<<<<<....{.).>>>>>..<<<<<<<<.<<<.<<......<<<<..{.<<<..<<<<..<<<.<<<<<.<<<<.<.<<<<<<(.<...........<<(.<..<<.<....><<<<<<<<....>>>>>>>>....>>.....>......>>)....>>).>>>>>>..>>>>...<(.<......>>)...].>>>>>.>>>...>>>>.....>.>..<....<<.<<<...........>>>.>>..<<...[.<<<<....<<<<<<.......>>>>>>))....<.....>.......>>>>.....<<<<..<<<......>>>..>>>>.<<<....>>>.>>..].<<.......<<<<<<.........>>>>>>.......>>.......>>>}....>>>>.....}.<<<<..<<<<<<<<..<<..(....>>>).>>>>>>>...>>>..>........<<<....<<]].<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>......>>>>.......>..}.....<<<<<<<>...>>>.>>>>....>>..>>>>>>>>>>>....<<<<<<<...<<<<...<<<<<<...........>...>>.>>>..<<<<<...<<<<...<<<<<<<<<<.....>>.>>>...>>>>>...>>>>.>>>>>...<<<.<..<<<<........<...>>>>>...>>>>.>>>>.......>>>>>>><.<<<<.....>>>>....<<.<.<<<<.......>>>>>....<<<<<<<<<<......<<<<......>>>>...}>>..>>>>>.>>>.....>>>...>>>>..>. (...(((..........((.(((((.....(..((...((((..........((........[[..........((((((.......]].............))))))....))....(........)(.(((.(......).))).)..(((........)))........(((((...................)))))......................((((....................))))...(......(((.(((.......))).))).......((..(..............((((..((.........(((.(.....)))).........((.........))..........))...))))..........)...)).....((((.................))))..........(.....).........).........))))....))..............(......).....).......................................))))).))............(((..((........))..))).....................((((.....(((((.((.((...........(.......)......................(.......).........)).)).)))))..((.....(((((......((((.......((.(....((((........)))).....).))...((...(((..........)))..)).........))))...((.......)).......)))))........)).....((.....((((......))))..(.(((((..(...((((.((........................((........))........[................)).))))....).))))).)......(.((((............))))..).....((........))...((((.(.....(((........((((((...........((....((((((..........((((......((((.......))))..............((......))...))))......))))))...))....................)))))).))).....)))))....(((......)))...........)).....................(((..............)))......................)))).(......((.....(((((.........))))).(......(((...((....((((...............)))).......(((..((...((....((......))....))...))....(((..........)))....(((((((((..............((((........((((...((..............))..(.....(...((...(((((..............)))))........)).)......).......................)))).........))))......................)))))))))..)))..)).................)))..(((......))).....)...(((.....(((((((..((................((((...............)))).((((((.(((........)).).))))))............((((.(......................(.((............................)).).(((.........(...((..((....((.....((......)).....))....)))).....)...........................................(((((.......)))))............)))......).)))).....))..)))))))..)))))....)........((..........))....((((((((.((..........((((.......(.......(((...((..(((.......(((((....................(.......(((((..........)))))....).....................))))).......)))...(............).....))...)))............(.....)....((((.............))))...........(((....(((((.........))))).]..................)))......(((..................))).((......))................(((.(((........)))))).................)......))))........((....((((((...((.......))...)))))).....))..................((...((.(((.(........).)))...)).((((.......))))......))..................((((((......)).)))).........))))))))))....((((((....((((....(((...................)))...(.((....((.....((((((((((.....)).)))...))))).....))..)).)...(((....(((((...........)))))....))).))))........))))))..(((.......)))....(....(((.........))).....(((.(((.(........(((......)))......)...)))..)))......).....)))..). Structure of the E. coli ribosomal termination complex with release factor 2; 50S 23S RIBOSOMAL RNA 1mme A 16 3.1 URS000080DF69_32630 7541315 32630 guggucugaugaggcc ................ ................ THE CRYSTAL STRUCTURE OF AN ALL-RNA HAMMERHEAD RIBOZYME: A PROPOSED MECHANISM FOR RNA CATALYTIC CLEAVAGE; RNA HAMMERHEAD RIBOZYME 1mme B 25 3.1 URS000080E0D1_32630 7541315 32630 ggccgaaacucguaagagucaccac ........<<<....>>>....... .......((((....))))...... THE CRYSTAL STRUCTURE OF AN ALL-RNA HAMMERHEAD RIBOZYME: A PROPOSED MECHANISM FOR RNA CATALYTIC CLEAVAGE; RNA HAMMERHEAD RIBOZYME 1mme C 16 3.1 URS000080DF69_32630 7541315 32630 guggucugaugaggcc ................ ................ THE CRYSTAL STRUCTURE OF AN ALL-RNA HAMMERHEAD RIBOZYME: A PROPOSED MECHANISM FOR RNA CATALYTIC CLEAVAGE; RNA HAMMERHEAD RIBOZYME 1mme D 25 3.1 URS000080E0D1_32630 7541315 32630 ggccgaaacucguaagagucaccac ........<<<....>>>....... ........(((....)))....... THE CRYSTAL STRUCTURE OF AN ALL-RNA HAMMERHEAD RIBOZYME: A PROPOSED MECHANISM FOR RNA CATALYTIC CLEAVAGE; RNA HAMMERHEAD RIBOZYME 1mwl A 21 2.4 URS000080E2C5_32630 12589761 32630 gcgucacaccggugaagucgc ..................... ..................... Crystal structure of geneticin bound to the eubacterial 16S rRNA A site; 5'-R(*CP*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*C)-3' 1mwl B 21 2.4 URS000080E2C5_32630 12589761 32630 gcgucacaccggugaagucgc ..................... ..................... Crystal structure of geneticin bound to the eubacterial 16S rRNA A site; 5'-R(*CP*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*C)-3' 1my9 A 14 NA URS000080E08F_32630 12367521 32630 ggagguuuuggagg .............. .............. Solution structure of a K+ cation stabilized dimeric RNA quadruplex containing two G:G(:A):G:G(:A) hexads, G:G:G:G tetrads and UUUU loops; 5'-R(*GP*GP*AP*GP*GP*UP*UP*UP*UP*GP*GP*AP*GP*G)-3' 1my9 B 14 NA URS000080E08F_32630 12367521 32630 ggagguuuuggagg .............. .............. Solution structure of a K+ cation stabilized dimeric RNA quadruplex containing two G:G(:A):G:G(:A) hexads, G:G:G:G tetrads and UUUU loops; 5'-R(*GP*GP*AP*GP*GP*UP*UP*UP*UP*GP*GP*AP*GP*G)-3' 1n32 A 1513 3.0 RF00177,RF01959,RF01960 URS000080E226_274 12464183 0003735 0005840 274 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucacuuucu ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<.......>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<<....>>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<...<<<.....>>>.>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.....)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((....(((((((....)))))))....(((....))).....))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(....(((.....)))..)...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Structure of the Thermus thermophilus 30S ribosomal subunit bound to codon and near-cognate transfer RNA anticodon stem-loop mismatched at the first codon position at the a site with paromomycin; 16S RIBOSOMAL RNA 1n32 Y 15 3.0 URS000080DD28_274 12464183 274 uaccuugagguggua <<<<.......>>>> ((((.......)))) Structure of the Thermus thermophilus 30S ribosomal subunit bound to codon and near-cognate transfer RNA anticodon stem-loop mismatched at the first codon position at the a site with paromomycin; ANTICODON STEM-LOOP OF LEU-2 TRANSFER RNA 1n33 A 1513 3.35 RF00177,RF01959,RF01960 URS000080E226_274 12464183 0003735 0005840 274 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucacuuucu ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<.......>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<....<<.<<<<....>>>>.>>...<<<<....>>>>....>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<...<<<.....>>>.>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<...<<<<....>>>>...>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<<..>>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.....)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(.(((.....((.]]])).......))).))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((.(..((((((((((......((........))..........(((((((......(((.......(((((((....))))))).....(......).........)))..((.(((...((..((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(....(((.....)))..)...)))))))..(..(((((....))))).....)..)))).....).).).....)).)))))....)))))))..[)).)))))))).(...(((((((.....(((...(..((((....))))..).....))).....)))))))......(....(((((((........)))))))....)..)..).))).....(.(((((......]...))))).)......))...)))))))))).))..(.(..((.(.(.((.(((..(.(((((((((((...(.((((....(((....))).)))).)..))))))))))).)..))).)).)..).))...)..)..(((((((((....)))))))))}........... Structure of the Thermus thermophilus 30S ribosomal subunit bound to codon and near-cognate transfer rna anticodon stem-loop mismatched at the second codon position at the a site with paromomycin; 16S RIBOSOMAL RNA 1n33 Y 11 3.35 URS000080E2C2_274 12464183 274 gccuggaaagu <<.......>> .(.......). Structure of the Thermus thermophilus 30S ribosomal subunit bound to codon and near-cognate transfer rna anticodon stem-loop mismatched at the second codon position at the a site with paromomycin; ANTICODON STEM-LOOP OF SER TRANSFER RNA 1n34 A 1513 3.8 RF00177,RF01959,RF01960 URS000080E226_274 12464183 0003735 0005840 274 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucacuuucu ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<.......>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>........<.<<<<<<<.......<<<<<.....<..............>....<<<......>>>....>>>>>..<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...............>....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>>..>>.>>>>>>>>.....<<<<<<<.....<<<....<.<<<<....>>>>..>.....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ ....((((..[.[[[..)))).((((.(((((..(((((.(((....(((..((..(((..((.(....(((((.....)))))....).)))))......(((......(((((((...((...(((((((.((.((....((((((....)))))).....)).))....((((.(((((....))))).))))...((.......)).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..(.((.(((....)))....)).)))).(((((............))))).(..(....)..)...)).))).).....(.(((...(.(........)..))))).))..)))))..(.........((((....))))........)....(((((...(.....((.......))......)....)))))......((((([[[...(..((.....((.]]])).......).).))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((....(((.........)))....))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((....((((((((((......((........))..........(((((.........((((.((..((..............)).....((....).)....))))))...(..((....(..(((......(((((((((....)))...(((......)))...)))))).....((((.((((.....((..............).)......))))........(......)...........)))).......).)).....)..)).)......)))))..[)).)))))))).(...((.((((.....(.(..((..((.(....).))..))....).).....)))).))......(....(((((((........)))))))....)..)....))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((...(..(.(((..(.(..((((((((...(.((((....(((....))).)))).)..))))))))..).)..))).)..)....))...)..)..(((((((((....)))))))))}........... Structure of the Thermus thermophilus 30S ribosomal subunit in the presence of codon and crystallographically disordered near-cognate transfer rna anticodon stem-loop mismatched at the first codon position; 16S RIBOSOMAL RNA 1n53 A 16 NA URS000080E0CF_32630 12547201 32630 gaggguggaaccgcgc ................ ................ SOLUTION STRUCTURE OF B. SUBTILIS T BOX ANTITERMINATOR RNA; RNA (5'-R(*GP*AP*GP*GP*GP*UP*GP*GP*AP*AP*CP*CP*GP*CP*GP*C)-3') 1n8r A 2754 3.0 RF02540,RF00002 URS000080DFCD_2238 12860128 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagccauggggagccgcacggaggcgaagaaccauggauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaaugugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucucgacgaagucucuuggaacagagcgugauacagggugacaaccccguacucgagaccaguacgacgugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccucgacgaaugaccgacgcgcgagcguccaguaagacucacgggaagccgauguucugucguacguuuugaaaaacgagccagggagugugucugcauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgccguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaaguaggggugaaaacuccuauggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucauaccgcaacucgacuaugacgaaaugggaaacggguuaauauucccgugccacuaugcagugaaaguugacgcccuggggucgaucacgcugggcaucgcccagucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcauaguguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcgaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggcuaucucagccggggacccggcgaagagugcaagagcaaaagauagcuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugagguuguucgccuauuaaaggaggucgugagcuggguuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>..<<<<<<.....<<.....>>....>>>>>>..<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<..<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>..>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<..<<.........<<<<<....>>>>>.........>>..>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<...<<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>>.<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<.<<<.....>>>.>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<<...<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>.>>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......(..(.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......)..)...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((..((....(....(((((....))))).....)...))..))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Structure of large ribosomal subunit in complex with virginiamycin M; 23S ribosomal RNA 1n8r B 122 3.0 RF00001 URS00003592C7_2238 12860128 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccggggaguacuggagugcgcgagccucugggaaacccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<<<<.....<<<<<<.<<....>>>>>>>>....>>>>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...(((((.....((((((.((....))))))))....)))))...))))))... Structure of large ribosomal subunit in complex with virginiamycin M; 5S ribosomal RNA 1nji A 2754 3.0 RF02540,RF00002 URS000080DFCD_2238 12860128 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagccauggggagccgcacggaggcgaagaaccauggauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaaugugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucucgacgaagucucuuggaacagagcgugauacagggugacaaccccguacucgagaccaguacgacgugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccucgacgaaugaccgacgcgcgagcguccaguaagacucacgggaagccgauguucugucguacguuuugaaaaacgagccagggagugugucugcauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgccguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaaguaggggugaaaacuccuauggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucauaccgcaacucgacuaugacgaaaugggaaacggguuaauauucccgugccacuaugcagugaaaguugacgcccuggggucgaucacgcugggcaucgcccagucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcauaguguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcgaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggcuaucucagccggggacccggcgaagagugcaagagcaaaagauagcuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugagguuguucgccuauuaaaggaggucgugagcuggguuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>..<<<<<<.....<<.....>>....>>>>>>..<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<..<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>..>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<..<<.........<<<<<....>>>>>.........>>..>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<...<<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>>.<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<.<<<.....>>>.>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<<...<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>.>>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......(..(.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......)..)...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((..((....(....(((((....))))).....)...))..))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Structure of chloramphenicol bound to the 50S ribosomal subunit; 23S ribosomal RNA 1nji B 122 3.0 RF00001 URS00003592C7_2238 12860128 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccggggaguacuggagugcgcgagccucugggaaacccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<<<<.....<<<<<<.<<....>>>>>>>>....>>>>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...(((((.....((((((.((....))))))))....)))))...))))))... Structure of chloramphenicol bound to the 50S ribosomal subunit; 5S ribosomal RNA 1njm 0 2766 3.6 RF02540,RF02541 URS000080DEF1_1299 12535524 0003735 0005840 1299 ggucaagauaguaaggguccacgguggaugcccuggcgcuggagccgaugaaggacgcgauuaccugcgaaaagccccgacgagcuggagauacgcuuugacucggggauguccgaauggggaaacccaccucguaagagguauccgcaaggaugggaacucagggaacugaaacaucucaguaccugaaggagaagaaagagaauucgauuccguuaguagcggcgagcgaacccggaucagcccaaauucaaccccucaagccgaaguggcuggaaagcuacaccucagaaggugagaguccuguaggcgaacgagcgguugacuguaaggucguuguucgugaaacgaugacugaauccgcgcggaccaccgcgcaaggcuaaauacucccagugaccgauagcgcauaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaagagaaccugaaaccguggacuuacaagcagucauggcaccuuaugcguguuauggcgugccuauugaagcaugagccggcgacuuagaccugacgugcgagcuuaaguugaaaaacggaggcggagcgaaagcgaguccgaauagggcggcauuaguacgucgggcuagacucgaaaccaggugagcuaagcaugaccagguugaaacccccgugacagggggcggaggaccgaaccggugccugcugaaacagucucggaugaguuguguuuaggagugaaaagcuaaccgaaccuggagauagcuaguucuccccgaaauguauugagguacagccucggauguugaccauguccuguagagcacucacaaggcuaaaaccuuaugaaacuccgaaggggcacgcguuuaguccgggagugaggcugcgagagcuaacuuccguagccgagagggaaacaacccagaccaucagcuaaggucccuaaaugaucgcucagugguuaaggaugugucgucgcauagacagccaggagguuggcuuagaagcagccacccuucaaagagugcguaauagcucacuggucgagugacgaugcgccgaaaaugaucggggcucaagugaucuaccgaagcuauggauucaacucgcgaagcgaguugucugguaggggagcguucaguccgcggagaagccauaccggaaggagugguggagccgacugaagugcggaugccggcaugaguaacgauaaaagaagugagaaucuucuucgccguaaggacaaggguuccuggggaagggucguccgcccagggaaagucgggaccuaaggugaggccgaacggcgcagccgauggacagcaggucaagauuccugcaccgaucauguggagugauggagggacgcauuacgcuauccaaugccaagcuauggcuaugcugguugguacgcucaagggcgaucgggucagaaaaucuaccggucacaugccucagacguaucgggagcuuccucggaagcgaaguuggaaacgcgacggugccaagaaaagcuucuaaacguugaaacaugauugcccguaccgcaaaccgacacagguguccgagugucaaugcacuaaggcgcgcgagagaacccucguuaaggaacuuugcaaucucaccccguaacuucggaagaagggguccccacgcuucgcguggggcgcagugaauaggcccaggcgacuguuuaccaaaaucacagcacucugccaacacgaacaguggacguauagggugugacgccugcccggugccggaaggucaaguggagcggugcaagcugcgaaaugaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaggcguaacgaucugggcgcugucucaacgagggacucggugaaauugaauuggcuguaaagaugcggccuacccguagcaggacgaaaagaccccguggagcuuuacuauagucuggcauugggauucggguuucucugcguaggugggagaaacuggccggucgguggccacccugagaaacuuggauuucuaaccugaaaaaucacuuucggggaccgugcuuggcggguaguuugacuggggcggucgccucccaaaauguaacggaggcgcccaaaggucaccucaagacgguuggaaaucgucuguagagcgcaaagguagaagguggcuugacugcgagacugacacgucgagcagggaggaaacucgggcuuagugaaccggugguaccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagaguccauaucggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgcuacgggcgcaggagaauugaggggaguugcuccuaguacgagaggaccggagugaacggaccgcuggucucccugcugucguaccaacggcacaugcaggguagcuauguccggaacggauaaccgcugaaagcaucuaagcgggaagccagccccaagaugaguucucccacuguucagguaagacucccggaagaccaccggguuaagaggccaggcgugcacgcauagcaauguguucagcggacuggugcucaucagucgaggucuugacca <<<<<<<<......<<<<<<<<<<<....<<<..<<<<<<<<<<<<......<<<<<<<((..((>>>>.....<<<<<<...<<.))..))..>>......>>>>>>...>>>....<<<....>>><<<<<....>>>>><<<<....>>>>>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<......<<.....>>.....>>>>...<<<.....<<<<<<.<<<..<<<....<<<<......>>>>.((......<<<.....))>>>...>>>....>>>.>>>>>>......<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>..............<<....>>....>>.........<<<<....>>>>.............>....>>>>>>>>>>>.......<<<<<<<<<<.......>>>>>>>>>>...<.<........>.>.<<<<<<....<<<.<<<<<<<<<<..<<<...<<......>>...>>>...<<....>>...<<.......>>........>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<.....<<<<<......>>>>>......>>>...<<<..<.<<........>>.>.>>>....>>>>>>>>>>..<<.......>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<...<<<<.<<<<<....<<....<<<.<<<<......>>>>.>>>...>.>....>>>>>.>.>>>..>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<..........<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>......>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>>...<<<<<<<.....>>>>>>>.......>>>>>>..<<<<<<<.<<......<<<<<.<<....>>.>>>>>...>>.>>>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<..<.<..<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<<..>>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<...<<...<<<<....<<<<..<<<..<<<<<.<<<<.<<...[[....>>>>>>..<<<<<.<<.<<<..<<<<<<.............>>>>>>.....>>>..>>>>>>>.....<<<<<....>>>>>....>>>>>...>>>...>>>>.........>>>>...>>......>>>>>>>>>>>>>..>>.....<<......>>.>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<<<...>>>>>>>>............<<<<<<<<<..<<...........>>..<<<<<<<.....<<<.....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<<....>.>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<..<<<<<<<<<<<.<<<<......<<<<<.....<<<<<<..>>>>>>..>>>>>..>>>>.>>>>>>>>>>>...<<<<<<........>>>>>>.....>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<<<<<<<<.<.<<.......>>..>>>>>>>>..>>>>.>.......<<<<<.<.<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>...>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.]].>>>>>>...>>>>>...>>>>.>>>>>....<<....<<<<.............>>>>....>>..>>>>.......>>>>>>>..<<<..>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>>>. ((((((((........(((((((((....(((..(((.((((((((......((((((.[[..[[[)))..]..((((((...((.]]..]]..))......))))))...)))....(((....)))(((((....)))))((((....))))))...((((((.....((....))......))))).).........((....))...((((......((.....)).....))))...(((.....((((((..((..(((...(((((......)))))[[(...).(((.....]])))...)))....))..))))))......((((.((((.......)))).))))......(((((..[[[[)))))..)))......)).)))).).))..............((....))....)).........((((....)))).............)....))))))))).........((((((((((.......))))))))))...(.(........).).((((((....(((.((((((((((..((....(((....)))....))...((....))....(.......).........)))))))))))))..((.(...((((((...(.(((((((((..((((....(((((......)))))....).)))...((...(.((........)).)..))....))))))))).).((.......))......))))))......).))..((((((....((..(....)..)).((.(((((..(((((.(((((....(.(...(((.((((......)))).)))..)..)....))))).).))).)))))).).)...(((((((.((......)).)))))))....(((......)))...((((.(((...((([[....(.((((((.....(.....((..((.(((((.(.......(((((.(((..((...........))..))).....(...((......)).).)))).)..).))))).)).))...........]].)....))))))))))...)))))))...((((((((...)))))))).......))))))(.(((.(((.((......((((..((....))..))))...)).))).)))..).....))))))(......((.....((((((.......)))))).(((....((((..((...((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](.(((((((...((....(((....(((((.(((..(((((..(((.((...{{....)))))...(((((.(((..(..((.(((....(.....)..))).)).....).)..))))))).....(((((....)))))....)))))...)))..)))))(..).....)))....))......))))))).)))))..)).....((......)).)))).((((......))))..)))...((((....((((((((.((..(....(........((((....(.[..).....)))).((((((((...))))))))(...).......((((((.((...(...........)...(((((((.....(((.....))).......))))))).]((((.(((..((.((((..(((....(...((.((....)).))...)....)))))))...)))))((((((......).)))))........((..........(((((.......)))))..)..)....))))...))..)))))).)..))).)))))))).)))))).....).....(((((........)))))..((((((((.(((..(......((((.((((((..(((((.(((..(((..((.((.(..(.(((((.(....(((((......(((.(()).)))...)))))).)))).))..).)).))...(((((((......))))))).....)))..)))..)))))..(((......[)))((((((..(....)..])))))).[((....((((((.(.(((((.........)))))...)..(][.[[[).....))))))....((((..(((...{..)))..)))).(((....))).))]]].].....((((((..((..]]]]..)).))))))......}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((.(((..((((((((........)))))..))).(((((.....))))).....))).)..)...))).))....(((((((....))).))))....)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...(.((...(((((((((((.}}.))))))...)))))...)).).)))))....((.(..((((.............))))...)))..))))..]....)))))))..(((..)))....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))....)))))))). The crystal structure of the 50S Large ribosomal subunit from Deinococcus radiodurans complexed with a tRNA acceptor stem mimic (ASM) and the antibiotic sparsomycin; 23S ribosomal RNA 1njm 5 25 3.6 URS000080E1F9_32630 12535524 32630 ggggcuaagccgcuuagcuccaccn <<<<<<<<<<.>>>>>>>>>>.... ((.(((((((.))))))).)).... The crystal structure of the 50S Large ribosomal subunit from Deinococcus radiodurans complexed with a tRNA acceptor stem mimic (ASM) and the antibiotic sparsomycin; tRNA acceptor stem mimic 1njo 0 2766 3.7 RF02540,RF02541 URS000080DEF1_1299 12535524 0003735 0005840 1299 ggucaagauaguaaggguccacgguggaugcccuggcgcuggagccgaugaaggacgcgauuaccugcgaaaagccccgacgagcuggagauacgcuuugacucggggauguccgaauggggaaacccaccucguaagagguauccgcaaggaugggaacucagggaacugaaacaucucaguaccugaaggagaagaaagagaauucgauuccguuaguagcggcgagcgaacccggaucagcccaaauucaaccccucaagccgaaguggcuggaaagcuacaccucagaaggugagaguccuguaggcgaacgagcgguugacuguaaggucguuguucgugaaacgaugacugaauccgcgcggaccaccgcgcaaggcuaaauacucccagugaccgauagcgcauaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaagagaaccugaaaccguggacuuacaagcagucauggcaccuuaugcguguuauggcgugccuauugaagcaugagccggcgacuuagaccugacgugcgagcuuaaguugaaaaacggaggcggagcgaaagcgaguccgaauagggcggcauuaguacgucgggcuagacucgaaaccaggugagcuaagcaugaccagguugaaacccccgugacagggggcggaggaccgaaccggugccugcugaaacagucucggaugaguuguguuuaggagugaaaagcuaaccgaaccuggagauagcuaguucuccccgaaauguauugagguacagccucggauguugaccauguccuguagagcacucacaaggcuaaaaccuuaugaaacuccgaaggggcacgcguuuaguccgggagugaggcugcgagagcuaacuuccguagccgagagggaaacaacccagaccaucagcuaaggucccuaaaugaucgcucagugguuaaggaugugucgucgcauagacagccaggagguuggcuuagaagcagccacccuucaaagagugcguaauagcucacuggucgagugacgaugcgccgaaaaugaucggggcucaagugaucuaccgaagcuauggauucaacucgcgaagcgaguugucugguaggggagcguucaguccgcggagaagccauaccggaaggagugguggagccgacugaagugcggaugccggcaugaguaacgauaaaagaagugagaaucuucuucgccguaaggacaaggguuccuggggaagggucguccgcccagggaaagucgggaccuaaggugaggccgaacggcgcagccgauggacagcaggucaagauuccugcaccgaucauguggagugauggagggacgcauuacgcuauccaaugccaagcuauggcuaugcugguugguacgcucaagggcgaucgggucagaaaaucuaccggucacaugccucagacguaucgggagcuuccucggaagcgaaguuggaaacgcgacggugccaagaaaagcuucuaaacguugaaacaugauugcccguaccgcaaaccgacacagguguccgagugucaaugcacuaaggcgcgcgagagaacccucguuaaggaacuuugcaaucucaccccguaacuucggaagaagggguccccacgcuucgcguggggcgcagugaauaggcccaggcgacuguuuaccaaaaucacagcacucugccaacacgaacaguggacguauagggugugacgccugcccggugccggaaggucaaguggagcggugcaagcugcgaaaugaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaggcguaacgaucugggcgcugucucaacgagggacucggugaaauugaauuggcuguaaagaugcggccuacccguagcaggacgaaaagaccccguggagcuuuacuauagucuggcauugggauucggguuucucugcguaggugggagaaacuggccggucgguggccacccugagaaacuuggauuucuaaccugaaaaaucacuuucggggaccgugcuuggcggguaguuugacuggggcggucgccucccaaaauguaacggaggcgcccaaaggucaccucaagacgguuggaaaucgucuguagagcgcaaagguagaagguggcuugacugcgagacugacacgucgagcagggaggaaacucgggcuuagugaaccggugguaccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagaguccauaucggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgcuacgggcgcaggagaauugaggggaguugcuccuaguacgagaggaccggagugaacggaccgcuggucucccugcugucguaccaacggcacaugcaggguagcuauguccggaacggauaaccgcugaaagcaucuaagcgggaagccagccccaagaugaguucucccacuguucagguaagacucccggaagaccaccggguuaagaggccaggcgugcacgcauagcaauguguucagcggacuggugcucaucagucgaggucuugacca <<<<<<<<......<<<<<<<<<<<....<<<..<<<<<<<<<<<<......<<<<<<<((..((>>>>.....<<<<<<...<<.))..))..>>......>>>>>>...>>>....<<<....>>><<<<<....>>>>><<<<....>>>>>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<......<<.....>>.....>>>>...<<<.....<<<<<<.<<<..<<<....<<<<......>>>>.((......<<<.....))>>>...>>>....>>>.>>>>>>......<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>..............<<....>>....>>.........<<<<....>>>>.............>....>>>>>>>>>>>.......<<<<<<<<<<.......>>>>>>>>>>...<.<........>.>.<<<<<<....<<<.<<<<<<<<<<..<<<...<<......>>...>>>...<<....>>...<<.......>>........>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<.....<<<<<......>>>>>......>>>...<<<..<.<<........>>.>.>>>....>>>>>>>>>>..<<.......>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<...<<<<.<<<<<....<<....<<<.<<<<......>>>>.>>>...>.>....>>>>>.>.>>>..>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<..........<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>......>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>>...<<<<<<<.....>>>>>>>.......>>>>>>..<<<<<<<.<<......<<<<<.<<....>>.>>>>>...>>.>>>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<..<.<..<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<<..>>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<...<<...<<<<....<<<<..<<<..<<<<<.<<<<.<<...[[....>>>>>>..<<<<<.<<.<<<..<<<<<<.............>>>>>>.....>>>..>>>>>>>.....<<<<<....>>>>>....>>>>>...>>>...>>>>.........>>>>...>>......>>>>>>>>>>>>>..>>.....<<......>>.>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<<<...>>>>>>>>............<<<<<<<<<..<<...........>>..<<<<<<<.....<<<.....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<<....>.>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<..<<<<<<<<<<<.<<<<......<<<<<.....<<<<<<..>>>>>>..>>>>>..>>>>.>>>>>>>>>>>...<<<<<<........>>>>>>.....>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<<<<<<<<.<.<<.......>>..>>>>>>>>..>>>>.>.......<<<<<.<.<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>...>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.]].>>>>>>...>>>>>...>>>>.>>>>>....<<....<<<<.............>>>>....>>..>>>>.......>>>>>>>..<<<..>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>>>. ((((((((........((((((((.....(((..(((.((((((((......((((((.[[..[[[)))..]..((((((...((.]]..]]..))......))))))...)))....(((....)))(((((....)))))((((....))))))...((((((.....((....))......))))).).........((....))...((((......((.....)).....))))...(((.....((((((..((..(((...(((((......)))))[[(...).(((.....]])))...)))....))..))))))......((((.((((.......)))).))))......(((((..[[[[)))))..)))......)).)))).).))..............((....))....)).........((((....)))).............).....)))))))).........((((((((((.......))))))))))...(.(........).).((((((....(((.((((((((((..((....(((....)))....))...((....))....(.......).........)))))))))))))..((.(...((((((...(.(((((((((..((((....(((((......)))))....).)))...((...(.((........)).)..))....))))))))).).((.......))......))))))......).))..((((((....((..(....)..)).((.(((((..(((((.(((((....(.(...(((.((((......)))).)))..)..)....))))).).))).)))))).).)...(((((((.((......)).)))))))....(((......)))...((((.(((...((([[....(.((((((.....(.....((..((.(((((.(.......(((((.(((..((...........))..))).....(...((......)).).)))).)..).))))).)).))...........]].)....))))))))))...)))))))...((((((((...)))))))).......))))))(.(((.(((.((......((((..((....))..))))...)).))).)))..).....))))))(......((.....((((((.......)))))).(((....((((..((...((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](.(((((((...((....(((....(((((.(((..(((((..(((.((...{{....)))))...(((((.(((..(..((.(((....(.....)..))).)).....).)..))))))).....(((((....)))))....)))))...)))..)))))(..).....)))....))......))))))).)))))..)).....((......)).)))).((((......))))..)))...((((....((((((((.((..(....(........((((....(.[..).....)))).((((((((...))))))))(...).......((((((.((...(...........)...(((((((.....(((.....))).......))))))).]((((.(((..((.((((..(((....(...((.((....)).))...)....)))))))...)))))((((((......).)))))........((..........(((((.......)))))..)..)....))))...))..)))))).)..))).)))))))).)))))).....).....(((((........)))))..((((((((.(((..(......((((.((((((..(((((.(((..(((..((.((.(..(.(((((.(....(((((......(((.(()).)))...)))))).)))).))..).)).))...(((((((......))))))).....)))..)))..)))))..(((......[)))((((((..(....)..])))))).[((....((((((.(.(((((.........)))))...)..(][.[[[).....))))))....((((..(((...{..)))..)))).(((....))).))]]].].....((((((..((..]]]]..)).))))))......}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((.(((..((((((((........)))))..))).(((((.....))))).....))).)..)...))).).....(((((((....))).))))....)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...(.((...(((((((((((.}}.))))))...)))))...)).).)))))....((.(..((((.............))))...)))..))))..]....)))))))..(((..)))....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))....)))))))). The crystal structure of the 50S Large ribosomal subunit from Deinococcus radiodurans complexed with a short substrate analog ACCPuromycin (ACCP); 23S ribosomal RNA 1njp 0 2766 3.5 RF02540,RF02541 URS000080DEF1_1299 12535524 0003735 0005840 1299 ggucaagauaguaaggguccacgguggaugcccuggcgcuggagccgaugaaggacgcgauuaccugcgaaaagccccgacgagcuggagauacgcuuugacucggggauguccgaauggggaaacccaccucguaagagguauccgcaaggaugggaacucagggaacugaaacaucucaguaccugaaggagaagaaagagaauucgauuccguuaguagcggcgagcgaacccggaucagcccaaauucaaccccucaagccgaaguggcuggaaagcuacaccucagaaggugagaguccuguaggcgaacgagcgguugacuguaaggucguuguucgugaaacgaugacugaauccgcgcggaccaccgcgcaaggcuaaauacucccagugaccgauagcgcauaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaagagaaccugaaaccguggacuuacaagcagucauggcaccuuaugcguguuauggcgugccuauugaagcaugagccggcgacuuagaccugacgugcgagcuuaaguugaaaaacggaggcggagcgaaagcgaguccgaauagggcggcauuaguacgucgggcuagacucgaaaccaggugagcuaagcaugaccagguugaaacccccgugacagggggcggaggaccgaaccggugccugcugaaacagucucggaugaguuguguuuaggagugaaaagcuaaccgaaccuggagauagcuaguucuccccgaaauguauugagguacagccucggauguugaccauguccuguagagcacucacaaggcuaaaaccuuaugaaacuccgaaggggcacgcguuuaguccgggagugaggcugcgagagcuaacuuccguagccgagagggaaacaacccagaccaucagcuaaggucccuaaaugaucgcucagugguuaaggaugugucgucgcauagacagccaggagguuggcuuagaagcagccacccuucaaagagugcguaauagcucacuggucgagugacgaugcgccgaaaaugaucggggcucaagugaucuaccgaagcuauggauucaacucgcgaagcgaguugucugguaggggagcguucaguccgcggagaagccauaccggaaggagugguggagccgacugaagugcggaugccggcaugaguaacgauaaaagaagugagaaucuucuucgccguaaggacaaggguuccuggggaagggucguccgcccagggaaagucgggaccuaaggugaggccgaacggcgcagccgauggacagcaggucaagauuccugcaccgaucauguggagugauggagggacgcauuacgcuauccaaugccaagcuauggcuaugcugguugguacgcucaagggcgaucgggucagaaaaucuaccggucacaugccucagacguaucgggagcuuccucggaagcgaaguuggaaacgcgacggugccaagaaaagcuucuaaacguugaaacaugauugcccguaccgcaaaccgacacagguguccgagugucaaugcacuaaggcgcgcgagagaacccucguuaaggaacuuugcaaucucaccccguaacuucggaagaagggguccccacgcuucgcguggggcgcagugaauaggcccaggcgacuguuuaccaaaaucacagcacucugccaacacgaacaguggacguauagggugugacgccugcccggugccggaaggucaaguggagcggugcaagcugcgaaaugaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaggcguaacgaucugggcgcugucucaacgagggacucggugaaauugaauuggcuguaaagaugcggccuacccguagcaggacgaaaagaccccguggagcuuuacuauagucuggcauugggauucggguuucucugcguaggugggagaaacuggccggucgguggccacccugagaaacuuggauuucuaaccugaaaaaucacuuucggggaccgugcuuggcggguaguuugacuggggcggucgccucccaaaauguaacggaggcgcccaaaggucaccucaagacgguuggaaaucgucuguagagcgcaaagguagaagguggcuugacugcgagacugacacgucgagcagggaggaaacucgggcuuagugaaccggugguaccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagaguccauaucggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgcuacgggcgcaggagaauugaggggaguugcuccuaguacgagaggaccggagugaacggaccgcuggucucccugcugucguaccaacggcacaugcaggguagcuauguccggaacggauaaccgcugaaagcaucuaagcgggaagccagccccaagaugaguucucccacuguucagguaagacucccggaagaccaccggguuaagaggccaggcgugcacgcauagcaauguguucagcggacuggugcucaucagucgaggucuugacca <<<<<<<<......<<<<<<<<<<<....<<<..<<<<<<<<<<<<......<<<<<<<((..((>>>>.....<<<<<<...<<.))..))..>>......>>>>>>...>>>....<<<....>>><<<<<....>>>>><<<<....>>>>>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<......<<.....>>.....>>>>...<<<.....<<<<<<.<<<..<<<....<<<<......>>>>.((......<<<.....))>>>...>>>....>>>.>>>>>>......<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>..............<<....>>....>>.........<<<<....>>>>.............>....>>>>>>>>>>>.......<<<<<<<<<<.......>>>>>>>>>>...<.<........>.>.<<<<<<....<<<.<<<<<<<<<<..<<<...<<......>>...>>>...<<....>>...<<.......>>........>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<.....<<<<<......>>>>>......>>>...<<<..<.<<........>>.>.>>>....>>>>>>>>>>..<<.......>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<...<<<<.<<<<<....<<....<<<.<<<<......>>>>.>>>...>.>....>>>>>.>.>>>..>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<..........<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>......>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>>...<<<<<<<.....>>>>>>>.......>>>>>>..<<<<<<<.<<......<<<<<.<<....>>.>>>>>...>>.>>>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<..<.<..<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<<..>>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<...<<...<<<<....<<<<..<<<..<<<<<.<<<<.<<...[[....>>>>>>..<<<<<.<<.<<<..<<<<<<.............>>>>>>.....>>>..>>>>>>>.....<<<<<....>>>>>....>>>>>...>>>...>>>>.........>>>>...>>......>>>>>>>>>>>>>..>>.....<<......>>.>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<<<...>>>>>>>>............<<<<<<<<<..<<...........>>..<<<<<<<.....<<<.....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<<....>.>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<..<<<<<<<<<<<.<<<<......<<<<<.....<<<<<<..>>>>>>..>>>>>..>>>>.>>>>>>>>>>>...<<<<<<........>>>>>>.....>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<<<<<<<<.<.<<.......>>..>>>>>>>>..>>>>.>.......<<<<<.<.<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>...>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.]].>>>>>>...>>>>>...>>>>.>>>>>....<<....<<<<.............>>>>....>>..>>>>.......>>>>>>>..<<<..>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>>>. ((((((((........(((((((((....(((..(((.((((((((......((((((.[[..[[[)))..]..((((((...((.]]..]]..))......))))))...)))....(((....)))(((((....)))))((((....))))))...((((((.....((....))......))))).).........((....))...((((......((.....)).....))))...(((.....((((((..((..(((...(((((......)))))[[(...).(((.....]])))...)))....))..))))))......((((.((((.......)))).))))......(((((..[[[[)))))..)))......)).)))).).))..............((....))....)).........((((....)))).............)....))))))))).........((((((((((.......))))))))))...(.(........).).((((((....(((.((((((((((..((....(((....)))....))...((....))....(.......).........)))))))))))))..((.(...((((((...(.(((((((((..((((....(((((......)))))....).)))...((...(.((........)).)..))....))))))))).).((.......))......))))))......).))..((((((....((..(....)..)).((.(((((..(((((.(((((....(.(...(((.((((......)))).)))..)..)....))))).).))).)))))).).)...(((((((.((......)).)))))))....(((......)))...((((.(((...((([[....(.((((((.....(.....((..((.(((((.(.......(((((.(((..((...........))..))).....(...((......)).).)))).)..).))))).)).))...........]].)....))))))))))...)))))))...((((((((...)))))))).......))))))(.(((.(((.((......((((..((....))..))))...)).))).)))..).....))))))(......((.....((((((.......)))))).(((....((((..((...((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](.(((((((...((....(((....(((((.(((..(((((..(((.((...{{....)))))...(((((.(((..(..((.(((....(.....)..))).)).....).)..))))))).....(((((....)))))....)))))...)))..)))))(..).....)))....))......))))))).)))))..)).....((......)).)))).((((......))))..)))...((((....((((((((.((..(....(........((((....(.[..).....)))).((((((((...))))))))(...).......((((((.((...(...........)...(((((((.....(((.....))).......))))))).]((((.(((..((.((((..(((....(...((.((....)).))...)....)))))))...)))))((((((......).)))))........((..........(((((.......)))))..)..)....))))...))..)))))).)..))).)))))))).)))))).....).....(((((........)))))..((((((((.(((..(......((((.((((((..(((((.(((..(((..((.((.(..(.(((((.(....(((((......(((.(()).)))...)))))).)))).))..).)).))...(((((((......))))))).....)))..)))..)))))..(((......[)))((((((..(....)..])))))).[((....((((((.(.(((((.........)))))...)..(][.[[[).....))))))....((((..(((...{..)))..)))).(((....))).))]]].].....((((((..((..]]]]..)).))))))......}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((.(((..((((((((........)))))..))).(((((.....))))).....))).)..)...))).))....(((((((....))).))))....)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...(.((...(((((((((((.}}.))))))...)))))...)).).)))))....((.(..((((.............))))...)))..))))..]....)))))))..(((..)))....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))....)))))))). The crystal structure of the 50S Large ribosomal subunit from Deinococcus radiodurans complexed with a tRNA acceptor stem mimic (ASM); 23S ribosomal RNA 1njp 5 25 3.5 URS000080E1F9_32630 12535524 32630 ggggcuaagccgcuuagcuccaccn <<<<<<<<<<.>>>>>>>>>>.... ((.(((((((.))))))).)).... The crystal structure of the 50S Large ribosomal subunit from Deinococcus radiodurans complexed with a tRNA acceptor stem mimic (ASM); tRNA acceptor stem mimic 1nkw 0 2766 3.1 RF02540,RF02541 URS000080DEF1_1299 11733066 0003735 0005840 1299 ggucaagauaguaaggguccacgguggaugcccuggcgcuggagccgaugaaggacgcgauuaccugcgaaaagccccgacgagcuggagauacgcuuugacucggggauguccgaauggggaaacccaccucguaagagguauccgcaaggaugggaacucagggaacugaaacaucucaguaccugaaggagaagaaagagaauucgauuccguuaguagcggcgagcgaacccggaucagcccaaauucaaccccucaagccgaaguggcuggaaagcuacaccucagaaggugagaguccuguaggcgaacgagcgguugacuguaaggucguuguucgugaaacgaugacugaauccgcgcggaccaccgcgcaaggcuaaauacucccagugaccgauagcgcauaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaagagaaccugaaaccguggacuuacaagcagucauggcaccuuaugcguguuauggcgugccuauugaagcaugagccggcgacuuagaccugacgugcgagcuuaaguugaaaaacggaggcggagcgaaagcgaguccgaauagggcggcauuaguacgucgggcuagacucgaaaccaggugagcuaagcaugaccagguugaaacccccgugacagggggcggaggaccgaaccggugccugcugaaacagucucggaugaguuguguuuaggagugaaaagcuaaccgaaccuggagauagcuaguucuccccgaaauguauugagguacagccucggauguugaccauguccuguagagcacucacaaggcuaaaaccuuaugaaacuccgaaggggcacgcguuuaguccgggagugaggcugcgagagcuaacuuccguagccgagagggaaacaacccagaccaucagcuaaggucccuaaaugaucgcucagugguuaaggaugugucgucgcauagacagccaggagguuggcuuagaagcagccacccuucaaagagugcguaauagcucacuggucgagugacgaugcgccgaaaaugaucggggcucaagugaucuaccgaagcuauggauucaacucgcgaagcgaguugucugguaggggagcguucaguccgcggagaagccauaccggaaggagugguggagccgacugaagugcggaugccggcaugaguaacgauaaaagaagugagaaucuucuucgccguaaggacaaggguuccuggggaagggucguccgcccagggaaagucgggaccuaaggugaggccgaacggcgcagccgauggacagcaggucaagauuccugcaccgaucauguggagugauggagggacgcauuacgcuauccaaugccaagcuauggcuaugcugguugguacgcucaagggcgaucgggucagaaaaucuaccggucacaugccucagacguaucgggagcuuccucggaagcgaaguuggaaacgcgacggugccaagaaaagcuucuaaacguugaaacaugauugcccguaccgcaaaccgacacagguguccgagugucaaugcacuaaggcgcgcgagagaacccucguuaaggaacuuugcaaucucaccccguaacuucggaagaagggguccccacgcuucgcguggggcgcagugaauaggcccaggcgacuguuuaccaaaaucacagcacucugccaacacgaacaguggacguauagggugugacgccugcccggugccggaaggucaaguggagcggugcaagcugcgaaaugaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaggcguaacgaucugggcgcugucucaacgagggacucggugaaauugaauuggcuguaaagaugcggccuacccguagcaggacgaaaagaccccguggagcuuuacuauagucuggcauugggauucggguuucucugcguaggugggagaaacuggccggucgguggccacccugagaaacuuggauuucuaaccugaaaaaucacuuucggggaccgugcuuggcggguaguuugacuggggcggucgccucccaaaauguaacggaggcgcccaaaggucaccucaagacgguuggaaaucgucuguagagcgcaaagguagaagguggcuugacugcgagacugacacgucgagcagggaggaaacucgggcuuagugaaccggugguaccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagaguccauaucggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgcuacgggcgcaggagaauugaggggaguugcuccuaguacgagaggaccggagugaacggaccgcuggucucccugcugucguaccaacggcacaugcaggguagcuauguccggaacggauaaccgcugaaagcaucuaagcgggaagccagccccaagaugaguucucccacuguucagguaagacucccggaagaccaccggguuaagaggccaggcgugcacgcauagcaauguguucagcggacuggugcucaucagucgaggucuugacca <<<<<<<<......<<<<<<<<<<<.....<<.<<<<<<<<<<<<<......<<<<<<<((..((>>>>.....<<<<<<...<<.))..))..>>......>>>>>>...>>>....<<<....>>><<<<<....>>>>>.<<<....>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<......<<.....>>.....>>>>...<<<.....<<<<<<.<<<..<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>....>>>.>>>>>>......<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>>.............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<.......>>>>>>>>>>...<.<........>.>.<<<<<<....<<<.<<<<<<<<<<...<<...<<......>>...>>....<<....>>...<........>.........>>>>>>>>>>>>>..<<.<..<<<<<<<....<<<<<<<<<<..<<<.....<<<<<......>>>>>......>>>...<<<..<.<<<......>>>.>.>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<...<<<<.<<<<<....<<....<<<.<<<<.<..>.>>>>.>>>...>.>....>>>>>.>.>>>..>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<..........<<<..<<<...<<.........>>...>>>.........<<......>>....>>>......>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>>..<.<<<<<<.....>>>>>>>.......>>>>>>..<<<<<<<.<<......<<<<<.<<....>>.>>>>>...>>.>>>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<<..>>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<...<<...<<<<....<<<<..<<<..<<<<<.<<<<.<<...[[....>>>>>>.<.<<<<.<<.<<<..<<<<<<.............>>>>>>.....>>>..>>>>>>>.....<<<<......>>>>....>>>>>...>>>...>>>>.........>>>>...>>......>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<...>>>>>>>>............<<<<<<<<<..<<...........>>..<<<<<<<.....<<<.....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<..<......<<<<.<<<<<<..<<<<<.<<<.<<<<..<<<<<<..<<<.<<<<.<....<<<<<.....<<<<<<..>>>>>>..>>>>>>.>>>>.>>>..>>>>>>...<<<<<<........>>>>>>.....>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<<<<<<<<.<.<<.......>>..>>>>>>>>..>>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....>...>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<....<<<...<<<<<<<<<<<.]].>>>>>>...>>>>>...>>>..>>>>>....<<....<<<<.............>>>>....>>..>>>>.......>>>>>>>..<<<..>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>>>. ((((((((........((((((((.....(((..(((.((((((((......(((((..[[..[[..)).....((((((...((.]]..]]..))......))))))...)))....(((....)))(((((....))))).(((....))).))...((((((.....((..[.))......))))).).........(......)...((((......((.]...)).....))))...(((.....((((((..((..(((...(((((......)))))[[(...).(((.....]])))...)))....))..))))))......((((.((((.......)))).))))......(((((..[[[[)))))..)))......)).)))).).))..............((....))....)).........((((....)))).............).....)))))))).......(.((((((((((.......)))))))))).[.(.(........).).((((((....(((.((((((((((..((....(((....)))....))...((....))......................)))))))))))))..((.(...((((((...(.(((((((((..((((....(((((......)))))....)[)))...(((..(.(((......))).).)))....))))))))).).((.......))......))))))......).))..((((((....(((((....))))).((.(((((..(((((.(((((....(.(...(((.((((......)))).)))..)..)....))))).).))).)))))).).)...(((((((.((......)).)))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((.(.......(((((.(((..(((.........)))..))).....(...((......)).).)))).)..).)))))))).))..........]]].)....))))))))))...)))))))...((((((((...)))))))).......))))))(.(((.(((.((......((((..((....))..))))...)).))).)))..).....))))))(......((.....((((((.......))))))((((....((((..((...((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](.(((((((...((.....((....(((((.(((..(((((..(((.((...{{....)))))..(.((((.(.(..(..((.(((....(.....)..))).)).....).)...)))))).....(((((....)))))....)))))...)))..)))))(..).....)).....))......))))))).)))))..)).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(........((((....(....).....)))).((((((((...))))))))(...).......((((((.((.].(...........)...(((((((.....(((.....))).......)))))))..((((.(((..((.((((..((.....(...((.((....)).))...).....))))))...)))))((((((......).)))))........((..........(((((.......)))))..)..)....))))...))..)))))).)..))).)))))))).)))))).....))....(((((.....]..)))))..((((((((.(((..(......((((.((((((..(((((.(((.((((..(((((.(..(.(((((.(....(((((.....((((.(()).))))..)))))).)))).))..).)))))...(((((((......))))))).....)))).)))..)))))..(((......[)))((((((..........]))))))([((....(.((((.(.(((((.........)))))...)..(][.[[[).....)))).)....((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((.(((..((((((.(........).)))..))).(((((.....))))).....))).)..)...))).).....(((((((....))).))))....)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...(.((...(((((((((((.}}.))))))...)))))...)).).)))))....((....((((.............))))....))..))))..]....)))))))..(((..)))....(((((((((.......)))))....(((.((((.((.....(((((....)))))....))..))))..)))...))))....)))))))). Crystal Structure Of The Large Ribosomal Subunit From Deinococcus Radiodurans; 23S ribosomal RNA 1nkw 9 118 3.1 RF00001 URS0000420396_1299 11733066 0003735 0005840 1299 cccccgugcccauagcacuguggaaccaccccaccccaugccgaacugggucgugaaacacagcagcgccaaugauacucggaccgcagggucccggaaaagucggucagcgcggggg <<<<<<<<<.....<<.<<<<<....<<<<<<<.............>>>>..>>>...>>>>>..>><<<.......<<.<<<<<....>>>>>.>>.......>>>..>>>>>>>>> .(((((.((.....((.(((((....((((((...............)))..)))...)))))..))(((.......((.(((((....))))).)).......)))..)).))))). Crystal Structure Of The Large Ribosomal Subunit From Deinococcus Radiodurans; 5S ribosomal RNA 1nlc A 23 1.85 URS000080E21C_32630 12736317 32630 cuugcugaggugcacacagcaag ....................... ....................... HIV-1 DIS(Mal) duplex Zn-soaked; HIV-1 DIS(MAL) genomic RNA 1nlc B 23 1.85 URS000080E21C_32630 12736317 32630 cuugcugaggugcacacagcaag ....................... ....................... HIV-1 DIS(Mal) duplex Zn-soaked; HIV-1 DIS(MAL) genomic RNA 1nta A 22 2.9 URS000080DE50_32630 12618190 32630 ggaucgcauuuggacuucugcc ...................... ...................... 2.9 A crystal structure of Streptomycin RNA-aptamer; 5'-R(*GP*GP*AP*UP*CP*GP*CP*AP*UP*UP*UP*GP*GP*AP*CP*UP*UP*CP*UP*GP*CP*C)-3' 1nta B 18 2.9 URS000080DFEE_32630 12618190 32630 cggcaccacggucggauc .................. .................. 2.9 A crystal structure of Streptomycin RNA-aptamer; 5'-R(*CP*GP*GP*CP*AP*CP*CP*AP*CP*GP*GP*UP*CP*GP*GP*AP*UP*C)-3' 1ntb A 22 2.9 URS000080DE50_32630 12618190 32630 ggaucgcauuuggacuucugcc ...................... ...................... 2.9 A crystal structure of Streptomycin RNA-aptamer complex; 5'-R(*GP*GP*AP*UP*CP*GP*CP*AP*UP*UP*UP*GP*GP*AP*CP*UP*UP*CP*UP*GP*CP*C)-3' 1ntb B 18 2.9 URS000080DFEE_32630 12618190 32630 cggcaccacggucggauc .................. .................. 2.9 A crystal structure of Streptomycin RNA-aptamer complex; 5'-R(*CP*GP*GP*CP*AP*CP*CP*AP*CP*GP*GP*UP*CP*GP*GP*AP*UP*C)-3' 1nuj A 13 1.8 URS000080DF09_32630 12911297 32630 cggaccgagccag ............. ............. THE LEADZYME STRUCTURE BOUND TO MG(H20)6(II) AT 1.8 A RESOLUTION; 5'-R(*CP*GP*GP*AP*CP*CP*GP*AP*GP*CP*CP*AP*G)-3' 1nuj B 11 1.8 URS000080E1D3_32630 12911297 32630 gcugggagucc ........... ........... THE LEADZYME STRUCTURE BOUND TO MG(H20)6(II) AT 1.8 A RESOLUTION; 5'-R(*GP*CP*UP*GP*GP*GP*AP*GP*UP*CP*C)-3' 1nuj C 13 1.8 URS000080DF09_32630 12911297 32630 cggaccgagccag ............. ............. THE LEADZYME STRUCTURE BOUND TO MG(H20)6(II) AT 1.8 A RESOLUTION; 5'-R(*CP*GP*GP*AP*CP*CP*GP*AP*GP*CP*CP*AP*G)-3' 1nuj D 11 1.8 URS000080E1D3_32630 12911297 32630 gcugggagucc ........... ........... THE LEADZYME STRUCTURE BOUND TO MG(H20)6(II) AT 1.8 A RESOLUTION; 5'-R(*GP*CP*UP*GP*GP*GP*AP*GP*UP*CP*C)-3' 1nuj E 13 1.8 URS000080DF09_32630 12911297 32630 cggaccgagccag ............. ............. THE LEADZYME STRUCTURE BOUND TO MG(H20)6(II) AT 1.8 A RESOLUTION; 5'-R(*CP*GP*GP*AP*CP*CP*GP*AP*GP*CP*CP*AP*G)-3' 1nuj F 11 1.8 URS000080E1D3_32630 12911297 32630 gcugggagucc ........... ........... THE LEADZYME STRUCTURE BOUND TO MG(H20)6(II) AT 1.8 A RESOLUTION; 5'-R(*GP*CP*UP*GP*GP*GP*AP*GP*UP*CP*C)-3' 1nuj G 13 1.8 URS000080DF09_32630 12911297 32630 cggaccgagccag ............. ............. THE LEADZYME STRUCTURE BOUND TO MG(H20)6(II) AT 1.8 A RESOLUTION; 5'-R(*CP*GP*GP*AP*CP*CP*GP*AP*GP*CP*CP*AP*G)-3' 1nuj H 11 1.8 URS000080E1D3_32630 12911297 32630 gcugggagucc ........... ........... THE LEADZYME STRUCTURE BOUND TO MG(H20)6(II) AT 1.8 A RESOLUTION; 5'-R(*GP*CP*UP*GP*GP*GP*AP*GP*UP*CP*C)-3' 1nuv A 13 1.81 URS000080DF09_32630 12911297 32630 cggaccgagccag ............. ............. The Leadzyme Ribozyme Bound to Mg(H2O)6(II) and Sr(II) at 1.8 A resolution; 5'-R(*CP*GP*GP*AP*CP*CP*GP*AP*GP*CP*CP*AP*G)-3' 1nuv B 11 1.81 URS000080E1D3_32630 12911297 32630 gcugggagucc ........... ........... The Leadzyme Ribozyme Bound to Mg(H2O)6(II) and Sr(II) at 1.8 A resolution; 5'-R(*GP*CP*UP*GP*GP*GP*AP*GP*UP*CP*C)-3' 1nuv C 13 1.81 URS000080DF09_32630 12911297 32630 cggaccgagccag ............. ............. The Leadzyme Ribozyme Bound to Mg(H2O)6(II) and Sr(II) at 1.8 A resolution; 5'-R(*CP*GP*GP*AP*CP*CP*GP*AP*GP*CP*CP*AP*G)-3' 1nuv D 11 1.81 URS000080E1D3_32630 12911297 32630 gcugggagucc ........... ........... The Leadzyme Ribozyme Bound to Mg(H2O)6(II) and Sr(II) at 1.8 A resolution; 5'-R(*GP*CP*UP*GP*GP*GP*AP*GP*UP*CP*C)-3' 1nuv E 13 1.81 URS000080DF09_32630 12911297 32630 cggaccgagccag ............. ............. The Leadzyme Ribozyme Bound to Mg(H2O)6(II) and Sr(II) at 1.8 A resolution; 5'-R(*CP*GP*GP*AP*CP*CP*GP*AP*GP*CP*CP*AP*G)-3' 1nuv F 11 1.81 URS000080E1D3_32630 12911297 32630 gcugggagucc ........... ........... The Leadzyme Ribozyme Bound to Mg(H2O)6(II) and Sr(II) at 1.8 A resolution; 5'-R(*GP*CP*UP*GP*GP*GP*AP*GP*UP*CP*C)-3' 1nuv G 13 1.81 URS000080DF09_32630 12911297 32630 cggaccgagccag ............. ............. The Leadzyme Ribozyme Bound to Mg(H2O)6(II) and Sr(II) at 1.8 A resolution; 5'-R(*CP*GP*GP*AP*CP*CP*GP*AP*GP*CP*CP*AP*G)-3' 1nuv H 11 1.81 URS000080E1D3_32630 12911297 32630 gcugggagucc ........... ........... The Leadzyme Ribozyme Bound to Mg(H2O)6(II) and Sr(II) at 1.8 A resolution; 5'-R(*GP*CP*UP*GP*GP*GP*AP*GP*UP*CP*C)-3' 1nwx 0 2766 3.5 RF02540,RF02541 URS000080DEF1_1299 12623020 0003735 0005840 1299 ggucaagauaguaaggguccacgguggaugcccuggcgcuggagccgaugaaggacgcgauuaccugcgaaaagccccgacgagcuggagauacgcuuugacucggggauguccgaauggggaaacccaccucguaagagguauccgcaaggaugggaacucagggaacugaaacaucucaguaccugaaggagaagaaagagaauucgauuccguuaguagcggcgagcgaacccggaucagcccaaauucaaccccucaagccgaaguggcuggaaagcuacaccucagaaggugagaguccuguaggcgaacgagcgguugacuguaaggucguuguucgugaaacgaugacugaauccgcgcggaccaccgcgcaaggcuaaauacucccagugaccgauagcgcauaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaagagaaccugaaaccguggacuuacaagcagucauggcaccuuaugcguguuauggcgugccuauugaagcaugagccggcgacuuagaccugacgugcgagcuuaaguugaaaaacggaggcggagcgaaagcgaguccgaauagggcggcauuaguacgucgggcuagacucgaaaccaggugagcuaagcaugaccagguugaaacccccgugacagggggcggaggaccgaaccggugccugcugaaacagucucggaugaguuguguuuaggagugaaaagcuaaccgaaccuggagauagcuaguucuccccgaaauguauugagguacagccucggauguugaccauguccuguagagcacucacaaggcuaaaaccuuaugaaacuccgaaggggcacgcguuuaguccgggagugaggcugcgagagcuaacuuccguagccgagagggaaacaacccagaccaucagcuaaggucccuaaaugaucgcucagugguuaaggaugugucgucgcauagacagccaggagguuggcuuagaagcagccacccuucaaagagugcguaauagcucacuggucgagugacgaugcgccgaaaaugaucggggcucaagugaucuaccgaagcuauggauucaacucgcgaagcgaguugucugguaggggagcguucaguccgcggagaagccauaccggaaggagugguggagccgacugaagugcggaugccggcaugaguaacgauaaaagaagugagaaucuucuucgccguaaggacaaggguuccuggggaagggucguccgcccagggaaagucgggaccuaaggugaggccgaacggcgcagccgauggacagcaggucaagauuccugcaccgaucauguggagugauggagggacgcauuacgcuauccaaugccaagcuauggcuaugcugguugguacgcucaagggcgaucgggucagaaaaucuaccggucacaugccucagacguaucgggagcuuccucggaagcgaaguuggaaacgcgacggugccaagaaaagcuucuaaacguugaaacaugauugcccguaccgcaaaccgacacagguguccgagugucaaugcacuaaggcgcgcgagagaacccucguuaaggaacuuugcaaucucaccccguaacuucggaagaagggguccccacgcuucgcguggggcgcagugaauaggcccaggcgacuguuuaccaaaaucacagcacucugccaacacgaacaguggacguauagggugugacgccugcccggugccggaaggucaaguggagcggugcaagcugcgaaaugaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaggcguaacgaucugggcgcugucucaacgagggacucggugaaauugaauuggcuguaaagaugcggccuacccguagcaggacgaaaagaccccguggagcuuuacuauagucuggcauugggauucggguuucucugcguaggugggagaaacuggccggucgguggccacccugagaaacuuggauuucuaaccugaaaaaucacuuucggggaccgugcuuggcggguaguuugacuggggcggucgccucccaaaauguaacggaggcgcccaaaggucaccucaagacgguuggaaaucgucuguagagcgcaaagguagaagguggcuugacugcgagacugacacgucgagcagggaggaaacucgggcuuagugaaccggugguaccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagaguccauaucggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgcuacgggcgcaggagaauugaggggaguugcuccuaguacgagaggaccggagugaacggaccgcuggucucccugcugucguaccaacggcacaugcaggguagcuauguccggaacggauaaccgcugaaagcaucuaagcgggaagccagccccaagaugaguucucccacuguucagguaagacucccggaagaccaccggguuaagaggccaggcgugcacgcauagcaauguguucagcggacuggugcucaucagucgaggucuugacca <<<<<<<<......<<<<<<<<<<<.....<<.<<<<<<<<<<<<<......<<<<<<<((..((>>>>.....<<<<<<...<<.))..))..>>......>>>>>>...>>>....<<<....>>><<<<<....>>>>>.<<<....>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<......<<.....>>.....>>>>...<<<.....<<<<<<.<<<..<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>....>>>.>>>>>>......<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>>.............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<.......>>>>>>>>>>...<.<........>.>.<<<<<<....<<<.<<<<<<<<<<...<<...<<......>>...>>....<<....>>...<........>.........>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<.....<<<<<......>>>>>......>>>...<<<<.<.<<<......>>>.>>>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<...<<<<.<<<<<....<<....<<<.<<<<.<..>.>>>>.>>>...>.>....>>>>>.>.>>>..>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<..........<<<..<<<...<<.........>>...>>>.........<<......>>....>>>......>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>>..<.<<<<<<.....>>>>>>>.......>>>>>>..<<<<<<<.<<......<<<<<.<<....>>.>>>>>...>>.>>>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<<..>>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<...<<...<<<<....<<<<..<<<..<<<<<.<<<<.<<...[[....>>>>>>.<.<<<<.<<.<<<..<<<<<<.............>>>>>>.....>>>..>>>>>>>.....<<<<<....>>>>>....>>>>>...>>>...>>>>.........>>>>...>>......>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<...>>>>>>>>............<<<<<<<<<..<<...........>>..<<<<<<<.....<<<.....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<..<<<<<<..<<<.<<<<.<....<<<<<.....<<<<<<..>>>>>>..>>>>>>.>>>>.>>>..>>>>>>...<<<<<<........>>>>>>.....>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<<<<<<<<.<.<<.......>>..>>>>>>>>..>>>>.>.......<<<<<.<.<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>...>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<....<<<...<<<<<<<<<<<.]].>>>>>>...>>>>>...>>>..>>>>>....<<....<<<<.............>>>>....>>..>>>>.......>>>>>>>..<<<..>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<......>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>>>. ((((((((........((((((((.....(((..(((.((((((((......(((((..[[..[[..)).....((((((...((.]]..]]..))......))))))...)))....(((....)))(((((....))))).(((....))).))...((((((.....((..[.))......))))).).........(......)...((((......((.]...)).....))))...(((.....((((((..((..(((...(((((......)))))[[(...).(((.....]])))...)))....))..))))))......((((.((((.......)))).))))......(((((..[[[[)))))..)))......)).)))).).))..............((....))....)).........((((....)))).............).....)))))))).......(.((((((((((.......)))))))))).[.(.(........).).((((((....(((.((((((((((..((....(((....)))....))...((....))......................)))))))))))))..((.(...((((((...(.(((((((((..((((....(((((......)))))....)[)))...(((..(.(((......))).).)))....))))))))).).((.......))......))))))......).))..((((((....(((((....))))).((.(((((..(((((.(((((....(.(...(((.((((......)))).)))..)..)....))))).).))).)))))).).)...(((((((.((......)).)))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((.(.......(((((.(((..(((.........)))..))).....(...((......)).).)))).)..).)))))))).))..........]]].)....))))))))))...)))))))...((((((((...)))))))).......))))))(.(((.(((.((......((((..((....))..))))...)).))).)))..).....))))))(......((.....((((((.......))))))((((....((((..((...((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](.(((((((...((....(((....(((((.(((..(((((..(((.((...{{....)))))..(.((((.(.(..(..((.(((....(.....)..))).)).....).)...)))))).....(((((....)))))....)))))...)))..)))))(..).....)))....))......))))))).)))))..)).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(........((((....(....).....)))).((((((((...))))))))(...).......((((((.((.].(...........)...(((((((.....(((.....))).......)))))))..((((.(((..((.((((..(((....(...((.((....)).))...)....)))))))...)))))((((((......).)))))........((..........(((((.......)))))..)..)....))))...))..)))))).)..))).)))))))).)))))).....))....(((((.....]..)))))..((((((((.(((..(......((((.((((((..(((((.(((..(((..(((((.(..(.(((((.(....(((((.....((((.(()).))))..)))))).)))).))..).)))))...(((((((......))))))).....)))..)))..)))))..(((......[)))((((((..........]))))))([((....(.((((.(.(((((.........)))))...)..(][.[[[).....)))).)....((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((.(((..((((((.(........).)))..))).(((((.....))))).....))).)..)...))).).....(((((((....))).))))....)...)))))))))))[...(((((((...((((..(.(((((.....(....)....))))).).(((((...(.((...(((((((((((.}}.))))))...)))))...)).).)))))....((....((((.............))))....))..))))..]....)))))))..(((..)))....(((((((((.......)))))....(((.((((.((.....(((((....)))))....))..))))..)))...))))....)))))))). COMPLEX OF THE LARGE RIBOSOMAL SUBUNIT FROM DEINOCOCCUS RADIODURANS WITH ABT-773; 23S RIBOSOMAL RNA 1nwx 9 118 3.5 RF00001 URS0000420396_1299 12623020 0003735 0005840 1299 cccccgugcccauagcacuguggaaccaccccaccccaugccgaacugggucgugaaacacagcagcgccaaugauacucggaccgcagggucccggaaaagucggucagcgcggggg <<<<<<<<<.....<<.<<<<<....<<<<<<<.............>>>>..>>>...>>>>>..>><<<.......<<.<<<<<....>>>>>.>>.......>>>..>>>>>>>>> .(((((.((.....((.(((((....((((((...............)))..)))...)))))..))(((.......((.(((((....))))).)).......)))..)).))))). COMPLEX OF THE LARGE RIBOSOMAL SUBUNIT FROM DEINOCOCCUS RADIODURANS WITH ABT-773; 5S RIBOSOMAL RNA 1nwy 0 2766 3.3 RF02540,RF02541 URS000080DEF1_1299 12623020 0003735 0005840 1299 ggucaagauaguaaggguccacgguggaugcccuggcgcuggagccgaugaaggacgcgauuaccugcgaaaagccccgacgagcuggagauacgcuuugacucggggauguccgaauggggaaacccaccucguaagagguauccgcaaggaugggaacucagggaacugaaacaucucaguaccugaaggagaagaaagagaauucgauuccguuaguagcggcgagcgaacccggaucagcccaaauucaaccccucaagccgaaguggcuggaaagcuacaccucagaaggugagaguccuguaggcgaacgagcgguugacuguaaggucguuguucgugaaacgaugacugaauccgcgcggaccaccgcgcaaggcuaaauacucccagugaccgauagcgcauaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaagagaaccugaaaccguggacuuacaagcagucauggcaccuuaugcguguuauggcgugccuauugaagcaugagccggcgacuuagaccugacgugcgagcuuaaguugaaaaacggaggcggagcgaaagcgaguccgaauagggcggcauuaguacgucgggcuagacucgaaaccaggugagcuaagcaugaccagguugaaacccccgugacagggggcggaggaccgaaccggugccugcugaaacagucucggaugaguuguguuuaggagugaaaagcuaaccgaaccuggagauagcuaguucuccccgaaauguauugagguacagccucggauguugaccauguccuguagagcacucacaaggcuaaaaccuuaugaaacuccgaaggggcacgcguuuaguccgggagugaggcugcgagagcuaacuuccguagccgagagggaaacaacccagaccaucagcuaaggucccuaaaugaucgcucagugguuaaggaugugucgucgcauagacagccaggagguuggcuuagaagcagccacccuucaaagagugcguaauagcucacuggucgagugacgaugcgccgaaaaugaucggggcucaagugaucuaccgaagcuauggauucaacucgcgaagcgaguugucugguaggggagcguucaguccgcggagaagccauaccggaaggagugguggagccgacugaagugcggaugccggcaugaguaacgauaaaagaagugagaaucuucuucgccguaaggacaaggguuccuggggaagggucguccgcccagggaaagucgggaccuaaggugaggccgaacggcgcagccgauggacagcaggucaagauuccugcaccgaucauguggagugauggagggacgcauuacgcuauccaaugccaagcuauggcuaugcugguugguacgcucaagggcgaucgggucagaaaaucuaccggucacaugccucagacguaucgggagcuuccucggaagcgaaguuggaaacgcgacggugccaagaaaagcuucuaaacguugaaacaugauugcccguaccgcaaaccgacacagguguccgagugucaaugcacuaaggcgcgcgagagaacccucguuaaggaacuuugcaaucucaccccguaacuucggaagaagggguccccacgcuucgcguggggcgcagugaauaggcccaggcgacuguuuaccaaaaucacagcacucugccaacacgaacaguggacguauagggugugacgccugcccggugccggaaggucaaguggagcggugcaagcugcgaaaugaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaggcguaacgaucugggcgcugucucaacgagggacucggugaaauugaauuggcuguaaagaugcggccuacccguagcaggacgaaaagaccccguggagcuuuacuauagucuggcauugggauucggguuucucugcguaggugggagaaacuggccggucgguggccacccugagaaacuuggauuucuaaccugaaaaaucacuuucggggaccgugcuuggcggguaguuugacuggggcggucgccucccaaaauguaacggaggcgcccaaaggucaccucaagacgguuggaaaucgucuguagagcgcaaagguagaagguggcuugacugcgagacugacacgucgagcagggaggaaacucgggcuuagugaaccggugguaccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagaguccauaucggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgcuacgggcgcaggagaauugaggggaguugcuccuaguacgagaggaccggagugaacggaccgcuggucucccugcugucguaccaacggcacaugcaggguagcuauguccggaacggauaaccgcugaaagcaucuaagcgggaagccagccccaagaugaguucucccacuguucagguaagacucccggaagaccaccggguuaagaggccaggcgugcacgcauagcaauguguucagcggacuggugcucaucagucgaggucuugacca 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COMPLEX OF THE LARGE RIBOSOMAL SUBUNIT FROM DEINOCOCCUS RADIODURANS WITH AZITHROMYCIN; 23S RIBOSOMAL RRNA 1nwy 9 118 3.3 RF00001 URS0000420396_1299 12623020 0003735 0005840 1299 cccccgugcccauagcacuguggaaccaccccaccccaugccgaacugggucgugaaacacagcagcgccaaugauacucggaccgcagggucccggaaaagucggucagcgcggggg <<<<<<<<<.....<<.<<<<<....<<<<<<<.............>>>>..>>>...>>>>>..>><<<.......<<.<<<<<....>>>>>.>>.......>>>..>>>>>>>>> .(((((.((.....((.(((((....((((((...............)))..)))...)))))..))(((.......((.(((((....))))).)).......)))..)).))))). COMPLEX OF THE LARGE RIBOSOMAL SUBUNIT FROM DEINOCOCCUS RADIODURANS WITH AZITHROMYCIN; 5S RIBOSOMAL RRNA 1nyi A 16 2.85 URS000080DF69_32630 12948485 32630 guggucugaugaggcc ................ ................ Crosslinked Hammerhead Ribozyme Initial State; 5'-R(P*GP*UP*GP*GP*UP*CP*UP*GP*AP*UP*GP*AP*GP*GP*CP*C)-3' 1nyi B 24 2.85 URS000080DF29_32630 12948485 32630 gccgaaacucguaagagucaccac .......<<<....>>>....... ......((((....))))...... Crosslinked Hammerhead Ribozyme Initial State; 5'-R(*GP*CP*CP*GP*AP*AP*AP*CP*UP*CP*GP*UP*AP*AP*GP*AP*GP*UP*CP*AP*CP*CP*AP*C)-3' 1o3z A 23 2.65 URS000080E21C_32630 12736317 32630 cuugcugaggugcacacagcaag ....................... ....................... HIV-1 DIS(MAL) DUPLEX RU HEXAMINE-SOAKED; HIV-1 DIS(MAL) GENOMIC RNA 1o3z B 23 2.65 URS000080E21C_32630 12736317 32630 cuugcugaggugcacacagcaag ....................... ....................... HIV-1 DIS(MAL) DUPLEX RU HEXAMINE-SOAKED; HIV-1 DIS(MAL) GENOMIC RNA 1o9m A 21 2.4 URS000080E2C5_562 12643685 562 gcgucacaccggugaagucgc ..................... ..................... The Complex of a novel antibiotic with the Aminoacyl Site of the Bacterial Ribosome Revealed by X-Ray Crystallography.; EUBACTERIAL A-SITE 1o9m B 21 2.4 URS000080E2C5_562 12643685 562 gcgucacaccggugaagucgc ..................... ..................... The Complex of a novel antibiotic with the Aminoacyl Site of the Bacterial Ribosome Revealed by X-Ray Crystallography.; EUBACTERIAL A-SITE 1ob5 B 77 3.1 RF00005 URS000080E06E_4932 16257965 0030533 4932 gcggauuuancucagnngggagagcnccaganunaagaunuggagnucnugugnucgnuccacagaauucgcacanc <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>..... (((((((..((((.....[..)))).((((.........)))).....(((((..]....)))))))))))).... T. aquaticus elongation factor EF-Tu complexed with the antibiotic enacyloxin IIa, a GTP analog, and Phe-tRNA; TRANSFER-RNA, PHE 1ob5 D 77 3.1 RF00005 URS000080E06E_4932 16257965 0030533 4932 gcggauuuancucagnngggagagcnccaganunaagaunuggagnucnugugnucgnuccacagaauucgcacanc <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>..... (((((((..((((.....[..)))).((((.........)))).....(((((..]....)))))))))))).... T. aquaticus elongation factor EF-Tu complexed with the antibiotic enacyloxin IIa, a GTP analog, and Phe-tRNA; TRANSFER-RNA, PHE 1ob5 F 77 3.1 RF00005 URS000080E06E_4932 16257965 0030533 4932 gcggauuuancucagnngggagagcnccaganunaagaunuggagnucnugugnucgnuccacagaauucgcacanc <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>..... (((((((..((((.....[..)))).((((.........)))).....(((((..]....)))))))))))).... T. aquaticus elongation factor EF-Tu complexed with the antibiotic enacyloxin IIa, a GTP analog, and Phe-tRNA; TRANSFER-RNA, PHE 1oo7 A 10 NA URS000080E30E_32630 12736318 32630 gaagagaagc .......... .......... DNA.RNA HYBRID DUPLEX CONTAINING A 5-PROPYNE DNA STRAND AND PURINE-RICH RNA STRAND, NMR, 4 STRUCTURES; 5'-R(*GP*AP*AP*GP*AP*GP*AP*AP*GP*C)-3' 1q29 A 17 3.0 URS000080E114_32630 12948485 32630 gguggucugaugaggcc ................. (...............) Hammerhead Ribozyme with 5'-5' G-G linkage: Conformational change experiment; 5'-R(*GP*GP*UP*GP*GP*UP*CP*UP*GP*AP*UP*GP*AP*GP*GP*CP*C)-3' 1q29 B 24 3.0 URS000080DF29_32630 12948485 32630 gccgaaacucguaagagucaccac .......<<<....>>>....... .......(((....)))....... Hammerhead Ribozyme with 5'-5' G-G linkage: Conformational change experiment; Ribozyme 1q7y A 2754 3.2 RF02540,RF00002 URS000080DFCD_2238 12185246 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagccauggggagccgcacggaggcgaagaaccauggauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaaugugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucucgacgaagucucuuggaacagagcgugauacagggugacaaccccguacucgagaccaguacgacgugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccucgacgaaugaccgacgcgcgagcguccaguaagacucacgggaagccgauguucugucguacguuuugaaaaacgagccagggagugugucugcauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgccguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaaguaggggugaaaacuccuauggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucauaccgcaacucgacuaugacgaaaugggaaacggguuaauauucccgugccacuaugcagugaaaguugacgcccuggggucgaucacgcugggcaucgcccagucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcauaguguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcgaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggcuaucucagccggggacccggcgaagagugcaagagcaaaagauagcuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugagguuguucgccuauuaaaggaggucgugagcuggguuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa 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...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......(..(.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......)..)...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......(...(((.....))).............)).....)))))))))......(.((((((((((....((((((..((....(....(((((....))))).....)...))..))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Crystal Structure of CCdAP-Puromycin bound at the Peptidyl transferase center of the 50S ribosomal subunit; 23S ribosomal rna 1q7y B 122 3.2 RF00001 URS00003592C7_2238 12185246 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccggggaguacuggagugcgcgagccucugggaaacccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<<<<.....<<<<<<.<<....>>>>>>>>....>>>>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...(((((.....((((((.((....))))))))....)))))...))))))... Crystal Structure of CCdAP-Puromycin bound at the Peptidyl transferase center of the 50S ribosomal subunit; 5S ribosomal RNA 1q81 A 2754 2.95 RF02540,RF00002 URS000080DFCD_2238 12185246 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagccauggggagccgcacggaggcgaagaaccauggauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaaugugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucucgacgaagucucuuggaacagagcgugauacagggugacaaccccguacucgagaccaguacgacgugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccucgacgaaugaccgacgcgcgagcguccaguaagacucacgggaagccgauguucugucguacguuuugaaaaacgagccagggagugugucugcauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgccguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaaguaggggugaaaacuccuauggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucauaccgcaacucgacuaugacgaaaugggaaacggguuaauauucccgugccacuaugcagugaaaguugacgcccuggggucgaucacgcugggcaucgcccagucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcauaguguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcgaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggcuaucucagccggggacccggcgaagagugcaagagcaaaagauagcuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugagguuguucgccuauuaaaggaggucgugagcuggguuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>..<<<<<<.....<<.....>>....>>>>>>..<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<..<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>..>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<..<<.........<<<<<....>>>>>.........>>..>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<.<<<.....>>>.>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<....<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>..>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......(..(.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......)..)...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((..((....(....(((((....))))).....)...))..))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Crystal Structure of minihelix with 3' puromycin bound to A-site of the 50S ribosomal subunit.; 23S ribosomal rna 1q81 B 122 2.95 RF00001 URS00003592C7_2238 12185246 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccggggaguacuggagugcgcgagccucugggaaacccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<<<<.....<<<<<<.<<....>>>>>>>>....>>>>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...(((((.....((((((.((....))))))))....)))))...))))))... Crystal Structure of minihelix with 3' puromycin bound to A-site of the 50S ribosomal subunit.; 5S ribosomal RNA 1q82 A 2754 2.98 RF02540,RF00002 URS000080DFCD_2238 12185246 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagccauggggagccgcacggaggcgaagaaccauggauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaaugugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucucgacgaagucucuuggaacagagcgugauacagggugacaaccccguacucgagaccaguacgacgugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccucgacgaaugaccgacgcgcgagcguccaguaagacucacgggaagccgauguucugucguacguuuugaaaaacgagccagggagugugucugcauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgccguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaaguaggggugaaaacuccuauggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucauaccgcaacucgacuaugacgaaaugggaaacggguuaauauucccgugccacuaugcagugaaaguugacgcccuggggucgaucacgcugggcaucgcccagucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcauaguguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcgaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggcuaucucagccggggacccggcgaagagugcaagagcaaaagauagcuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugagguuguucgccuauuaaaggaggucgugagcuggguuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>...<<<<<.....<<.....>>....>>>>>...<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<..<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>..>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<..<<.........<<<<<....>>>>>.........>>..>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<...<<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>>.<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<.<<<.....>>>.>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<....<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>..>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......(..(.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......)..)...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((..((....(....(((((....))))).....)...))..))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Crystal Structure of CC-Puromycin bound to the A-site of the 50S ribosomal subunit; 23S ribosomal rna 1q82 B 122 2.98 RF00001 URS00003592C7_2238 12185246 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccggggaguacuggagugcgcgagccucugggaaacccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<<<<.....<<<<<<.<<....>>>>>>>>....>>>>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...(((((.....((((((.((....))))))))....)))))...))))))... Crystal Structure of CC-Puromycin bound to the A-site of the 50S ribosomal subunit; 5S ribosomal RNA 1q86 A 2754 3.0 RF02540,RF00002 URS000080DFCD_2238 12185246 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagccauggggagccgcacggaggcgaagaaccauggauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaaugugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucucgacgaagucucuuggaacagagcgugauacagggugacaaccccguacucgagaccaguacgacgugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccucgacgaaugaccgacgcgcgagcguccaguaagacucacgggaagccgauguucugucguacguuuugaaaaacgagccagggagugugucugcauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgccguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaaguaggggugaaaacuccuauggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucauaccgcaacucgacuaugacgaaaugggaaacggguuaauauucccgugccacuaugcagugaaaguugacgcccuggggucgaucacgcugggcaucgcccagucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcauaguguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcgaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggcuaucucagccggggacccggcgaagagugcaagagcaaaagauagcuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugagguuguucgccuauuaaaggaggucgugagcuggguuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>...<<<<<.....<<.....>>....>>>>>...<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<..<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>..>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<..<<.........<<<<<....>>>>>.........>>..>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<...<<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>>.<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<.<<<.....>>>.>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<....<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>..>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......(..(.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......)..)...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((..((....(....(((((....))))).....)...))..))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Crystal structure of CCA-Phe-cap-biotin bound simultaneously at half occupancy to both the A-site and P-site of the the 50S ribosomal Subunit.; 23S ribosomal rna 1q86 B 122 3.0 RF00001 URS00003592C7_2238 12185246 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccggggaguacuggagugcgcgagccucugggaaacccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<<<<.....<<<<<<.<<....>>>>>>>>....>>>>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...(((((.....((((((.((....))))))))....)))))...))))))... Crystal structure of CCA-Phe-cap-biotin bound simultaneously at half occupancy to both the A-site and P-site of the the 50S ribosomal Subunit.; 5S ribosomal RNA 1qbp A 15 2.1 URS000080DD59_32630 10504226 32630 ugnnaguucgcuggc ............... ............... CRYSTAL STRUCTURE OF A BROMINATED RNA HELIX WITH FOUR MISMATCHED BASE PAIRS; 5'-R(*UP*GP*(CBV)P*(CBV)P*AP*GP*UP*UP*CP*GP*CP*UP*GP*GP*C)-3' 1qbp B 15 2.1 URS000080DD59_32630 10504226 32630 ugnnaguucgcuggc ............... ............... CRYSTAL STRUCTURE OF A BROMINATED RNA HELIX WITH FOUR MISMATCHED BASE PAIRS; 5'-R(*UP*GP*(CBV)P*(CBV)P*AP*GP*UP*UP*CP*GP*CP*UP*GP*GP*C)-3' 1qbp C 15 2.1 URS000080DD59_32630 10504226 32630 ugnnaguucgcuggc ............... ............... CRYSTAL STRUCTURE OF A BROMINATED RNA HELIX WITH FOUR MISMATCHED BASE PAIRS; 5'-R(*UP*GP*(CBV)P*(CBV)P*AP*GP*UP*UP*CP*GP*CP*UP*GP*GP*C)-3' 1qbp D 15 2.1 URS000080DD59_32630 10504226 32630 ugnnaguucgcuggc ............... ............... CRYSTAL STRUCTURE OF A BROMINATED RNA HELIX WITH FOUR MISMATCHED BASE PAIRS; 5'-R(*UP*GP*(CBV)P*(CBV)P*AP*GP*UP*UP*CP*GP*CP*UP*GP*GP*C)-3' 1qbp E 15 2.1 URS000080DD59_32630 10504226 32630 ugnnaguucgcuggc ............... ............... CRYSTAL STRUCTURE OF A BROMINATED RNA HELIX WITH FOUR MISMATCHED BASE PAIRS; 5'-R(*UP*GP*(CBV)P*(CBV)P*AP*GP*UP*UP*CP*GP*CP*UP*GP*GP*C)-3' 1qbp F 15 2.1 URS000080DD59_32630 10504226 32630 ugnnaguucgcuggc ............... ............... CRYSTAL STRUCTURE OF A BROMINATED RNA HELIX WITH FOUR MISMATCHED BASE PAIRS; 5'-R(*UP*GP*(CBV)P*(CBV)P*AP*GP*UP*UP*CP*GP*CP*UP*GP*GP*C)-3' 1qc0 B 10 1.55 URS000080E289_562 10555960 562 gcaccgcuac .......... .......... CRYSTAL STRUCTURE OF A 19 BASE PAIR COPY CONTROL RELATED RNA DUPLEX; 5'-R(GP*CP*AP*CP*CP*GP*CP*UP*AP*C)-3' 1qc0 C 19 1.55 URS000080DE9E_562 10555960 562 gcaccguugguagcggugc ................... ................... CRYSTAL STRUCTURE OF A 19 BASE PAIR COPY CONTROL RELATED RNA DUPLEX; 5'-R(*GP*CP*AP*CP*CP*GP*UP*UP*GP*GP*UP*AP*GP*CP*GP*GP*UP*GP*C)-3' 1qc0 D 19 1.55 URS000080DFF8_562 10555960 562 gcaccgcuaccaacggugc ................... ................... CRYSTAL STRUCTURE OF A 19 BASE PAIR COPY CONTROL RELATED RNA DUPLEX; 5'-R(*GP*CP*AP*CP*CP*GP*CP*UP*AP*CP*CP*AP*AP*CP*GP*GP*UP*GP*C)-3' 1qcu A 11 1.2 URS000080E243_32630 10555960 32630 ggggggggggg ........... ........... CRYSTAL STRUCTURE OF AN 18 BASE PAIR COPY CONTROL RELATED RNA DUPLEX; 5'-R(P*GP*GP*GP*GP*GP*GP*GP*GP*GP*GP*G)-3' 1qcu B 11 1.2 URS000080DF74_32630 10555960 32630 ccccccccccc ........... ........... CRYSTAL STRUCTURE OF AN 18 BASE PAIR COPY CONTROL RELATED RNA DUPLEX; 5'-R(P*CP*CP*CP*CP*CP*CP*CP*CP*CP*CP*C)-3' 1qcu C 11 1.2 URS000080DF74_32630 10555960 32630 ccccccccccc ........... ........... CRYSTAL STRUCTURE OF AN 18 BASE PAIR COPY CONTROL RELATED RNA DUPLEX; 5'-R(P*CP*CP*CP*CP*CP*CP*CP*CP*CP*CP*C)-3' 1qcu D 11 1.2 URS000080E243_32630 10555960 32630 ggggggggggg ........... ........... CRYSTAL STRUCTURE OF AN 18 BASE PAIR COPY CONTROL RELATED RNA DUPLEX; 5'-R(P*GP*GP*GP*GP*GP*GP*GP*GP*GP*GP*G)-3' 1qvf 0 2754 3.1 RF02540,RF00002 URS000080DFCD_2238 14561884 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagccauggggagccgcacggaggcgaagaaccauggauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaaugugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucucgacgaagucucuuggaacagagcgugauacagggugacaaccccguacucgagaccaguacgacgugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccucgacgaaugaccgacgcgcgagcguccaguaagacucacgggaagccgauguucugucguacguuuugaaaaacgagccagggagugugucugcauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgccguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaaguaggggugaaaacuccuauggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucauaccgcaacucgacuaugacgaaaugggaaacggguuaauauucccgugccacuaugcagugaaaguugacgcccuggggucgaucacgcugggcaucgcccagucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcauaguguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcgaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggcuaucucagccggggacccggcgaagagugcaagagcaaaagauagcuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugagguuguucgccuauuaaaggaggucgugagcuggguuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>...<<<<<.....<<.....>>....>>>>>...<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<..<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>..>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<..<<.........<<<<<....>>>>>.........>>..>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<...<<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>>.<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<.<<<.....>>>.>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<<...<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>.>>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......(..(.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......)..)...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((..((....(....(((((....))))).....)...))..))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Structure of a deacylated tRNA minihelix bound to the E site of the large ribosomal subunit of Haloarcula marismortui; 23S ribosomal rna 1qvf 9 122 3.1 RF00001 URS00003592C7_2238 14561884 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccggggaguacuggagugcgcgagccucugggaaacccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<<<<.....<<<<<<.<<....>>>>>>>>....>>>>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...(((((.....((((((.((....))))))))....)))))...))))))... Structure of a deacylated tRNA minihelix bound to the E site of the large ribosomal subunit of Haloarcula marismortui; 5S ribosomal RNA 1qvg 0 2754 2.9 RF02540,RF00002 URS000080DFCD_2238 14561884 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagccauggggagccgcacggaggcgaagaaccauggauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaaugugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucucgacgaagucucuuggaacagagcgugauacagggugacaaccccguacucgagaccaguacgacgugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccucgacgaaugaccgacgcgcgagcguccaguaagacucacgggaagccgauguucugucguacguuuugaaaaacgagccagggagugugucugcauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgccguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaaguaggggugaaaacuccuauggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucauaccgcaacucgacuaugacgaaaugggaaacggguuaauauucccgugccacuaugcagugaaaguugacgcccuggggucgaucacgcugggcaucgcccagucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcauaguguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcgaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggcuaucucagccggggacccggcgaagagugcaagagcaaaagauagcuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugagguuguucgccuauuaaaggaggucgugagcuggguuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>...<<<<<.....<<.....>>....>>>>>...<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<....<.<..<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>..>>..>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<..<<.........<<<<<....>>>>>.........>>..>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<.<<<.....>>>.>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<....<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>..>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......(..(.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......)..)...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((..((....(....(((((....))))).....)...))..))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.(((....(((((((....)))))))....[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).)........((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).).....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Structure of CCA oligonucleotide bound to the tRNA binding sites of the large ribosomal subunit of Haloarcula marismortui; 23S ribosomal rna 1qvg 9 122 2.9 RF00001 URS00003592C7_2238 14561884 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccggggaguacuggagugcgcgagccucugggaaacccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<<.............>>>>..>>....>>>>>>.>><..<<<<<.....<<<<<<.<<....>>>>>>>>....>>>>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...(((((.....((((((.((....))))))))....)))))...))))))... Structure of CCA oligonucleotide bound to the tRNA binding sites of the large ribosomal subunit of Haloarcula marismortui; 5S ribosomal RNA 1r3e D 17 2.1 URS000080DFF6_32630 14566049 32630 cuguguucgauccacag ................. ................. Crystal Structure of tRNA Pseudouridine Synthase TruB and Its RNA Complex: RNA-protein Recognition Through a Combination of Rigid Docking and Induced Fit; 5'-R(*CP*UP*GP*UP*GP*UP*UP*CP*GP*AP*UP*CP*CP*AP*CP*AP*G)-3' 1r3e E 17 2.1 URS000080DFF6_32630 14566049 32630 cuguguucgauccacag ................. ................. Crystal Structure of tRNA Pseudouridine Synthase TruB and Its RNA Complex: RNA-protein Recognition Through a Combination of Rigid Docking and Induced Fit; 5'-R(*CP*UP*GP*UP*GP*UP*UP*CP*GP*AP*UP*CP*CP*AP*CP*AP*G)-3' 1r9f B 20 1.85 URS000041F71C_32630 14661029 32630 cguacgcggaauacuucgau .................... .................... Crystal structure of p19 complexed with 19-bp small interfering RNA; 5'-R(*CP*GP*UP*AP*CP*GP*CP*GP*GP*AP*AP*UP*AP*CP*UP*UP*CP*GP*AP*UP*U)-3' 1r9f C 20 1.85 URS0000485571_32630 14661029 32630 ucgaaguauuccgcguacgu .................... .................... Crystal structure of p19 complexed with 19-bp small interfering RNA; 5'-R(*UP*CP*GP*AP*AP*GP*UP*AP*UP*UP*CP*CP*GP*CP*GP*UP*AP*CP*GP*UP*U)-3' 1rc7 B 10 2.15 URS000080E216_32630 15016361 32630 ggcgcgcgcc .......... .......... Crystal structure of RNase III Mutant E110K from Aquifex Aeolicus complexed with ds-RNA at 2.15 Angstrom Resolution; 5'-R(*GP*GP*CP*GP*CP*GP*CP*GP*CP*C)-3' 1rc7 C 10 2.15 URS000080E216_32630 15016361 32630 ggcgcgcgcc .......... .......... Crystal structure of RNase III Mutant E110K from Aquifex Aeolicus complexed with ds-RNA at 2.15 Angstrom Resolution; 5'-R(*GP*GP*CP*GP*CP*GP*CP*GP*CP*C)-3' 1rc7 D 10 2.15 URS000080E216_32630 15016361 32630 ggcgcgcgcc .......... .......... Crystal structure of RNase III Mutant E110K from Aquifex Aeolicus complexed with ds-RNA at 2.15 Angstrom Resolution; 5'-R(*GP*GP*CP*GP*CP*GP*CP*GP*CP*C)-3' 1rc7 E 10 2.15 URS000080E216_32630 15016361 32630 ggcgcgcgcc .......... .......... Crystal structure of RNase III Mutant E110K from Aquifex Aeolicus complexed with ds-RNA at 2.15 Angstrom Resolution; 5'-R(*GP*GP*CP*GP*CP*GP*CP*GP*CP*C)-3' 1rna A 14 2.25 URS000080E07D_32630 2479753 32630 uuauauauauauaa .............. .............. CRYSTALLOGRAPHIC STRUCTURE OF AN RNA HELIX: [U(U-A)6A]2; RNA (5'-R(*UP*UP*AP*UP*AP*UP*AP*UP*AP*UP*AP*UP*AP*A)-3') 1rna B 14 2.25 URS000080E07D_32630 2479753 32630 uuauauauauauaa .............. .............. CRYSTALLOGRAPHIC STRUCTURE OF AN RNA HELIX: [U(U-A)6A]2; RNA (5'-R(*UP*UP*AP*UP*AP*UP*AP*UP*AP*UP*AP*UP*AP*A)-3') 1rpu C 21 2.5 URS000080DDEE_32630 14697199 32630 cguacgcgucacgcguacguu ..................... ..................... Crystal Structure of CIRV p19 bound to siRNA; 5'-R(P*CP*GP*UP*AP*CP*GP*CP*GP*UP*CP*AP*CP*GP*CP*GP*UP*AP*CP*GP*UP*U)-3' 1rpu D 21 2.5 URS000080DDEE_32630 14697199 32630 cguacgcgucacgcguacguu ..................... ..................... Crystal Structure of CIRV p19 bound to siRNA; 5'-R(P*CP*GP*UP*AP*CP*GP*CP*GP*UP*CP*AP*CP*GP*CP*GP*UP*AP*CP*GP*UP*U)-3' 1rrr A 10 NA URS000080E30E_32630 9425027 32630 gaagagaagc .......... .......... RNA DUPLEX CONTAINING A PURINE-RICH STRAND, NMR, 10 STRUCTURES; RNA (5'-R(*GP*AP*AP*GP*AP*GP*AP*AP*GP*C)-3') 1rrr B 10 NA URS000080DFE7_32630 9425027 32630 gcuucucuuc .......... .......... RNA DUPLEX CONTAINING A PURINE-RICH STRAND, NMR, 10 STRUCTURES; RNA (5'-R(*GP*CP*UP*UP*CP*UP*CP*UP*UP*C)-3') 1ry1 E 49 12.0 RF00017,RF04277 URS000080E0CE_9615 14985753 0006617,0035195 0005786,0016442 9615 ggccgggcgcgguggcgcgcgccuguagucccagcuacucgggaggcuc <<<<<<<<<<<..(((.>>>>>>>....<<<<.)))....>>>>>>>>. (((((((((((..[[[.)))))))....((((.]]..]..)))))))). Structure of the signal recognition particle interacting with the elongation-arrested ribosome; SRP Alu domain 1ry1 A 128 12.0 RF00017,RF01856 URS000080DE1E_9615 14985753 0006617 0005786 9615 gacacuaaguucggcaucaauauggugaccucccgggagcgggggaccaccagguugccuaaggaggggugaaccggcccaggucggaaacggagcaggucaaaacucccgugcugaucaguagugun <<<<<<<.<.<<<<<<<<<<<.<<<<<..<<<<<<....>>>>>>..>>>>>.>>>>........<<<<<.....<<<<..<.<<<....>>>..>.>>>>...>>>>>.>>>>>>>.>..>>>>>>> ((((((..(.(((((((((((.(((((..((((((....))))))..))))).))))......(.(((((.....((((....(((....)))....))))...))))))))))))).)...)))))) Structure of the signal recognition particle interacting with the elongation-arrested ribosome; SRP S domain 1ry1 M 27 12.0 URS000080DEAE_9615 14985753 9615 aggcuggaggaucgcuugaguccagga ........................... ........................... Structure of the signal recognition particle interacting with the elongation-arrested ribosome; SRP RNA 1ry1 N 31 12.0 URS000080DF80_9615 14985753 9615 ccugugcaacauagcgagaccccgucucuuu ............................... ............................... Structure of the signal recognition particle interacting with the elongation-arrested ribosome; SRP RNA 1ry1 O 24 12.0 URS000080E1C0_9615 14985753 9615 guucugggcuguagugcgcuaugc ........................ ........................ Structure of the signal recognition particle interacting with the elongation-arrested ribosome; SRP RNA 1ry1 P 19 12.0 URS000080DFDD_9615 14985753 9615 aauagccacugcacuccag ................... ................... Structure of the signal recognition particle interacting with the elongation-arrested ribosome; SRP RNA 1ry1 Q 12 12.0 URS000080DE07_9615 14985753 9615 cgaucggguguc ............ ............ Structure of the signal recognition particle interacting with the elongation-arrested ribosome; SRP RNA 1ry1 R 12 12.0 URS000080DE5B_9615 14985753 9615 aucgcgccugug ............ ............ Structure of the signal recognition particle interacting with the elongation-arrested ribosome; SRP RNA 1s72 0 2754 2.4 RF02540,RF00002 URS000080DFCD_2238 15184028 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagccauggggagccgcacggaggcgaagaaccauggauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaaugugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucucgacgaagucucuuggaacagagcgugauacagggugacaaccccguacucgagaccaguacgacgugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccucgacgaaugaccgacgcgcgagcguccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucugcauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgccguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaaguaggggugaaaacuccuauggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucauaccgcaacucgacuaugacgaaaugggaaacggguuaauauucccgugccacuaugcagugaaaguugacgcccuggggucgaucacgcugggcaucgcccagucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcauaguguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcgaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggcuaucucagccggggacccggcgaagagugcaagagcaaaagauagcuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcugggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa 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...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......(..(.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......)..)...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((..((....(....(((((....))))).....)...))..))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. REFINED CRYSTAL STRUCTURE OF THE HALOARCULA MARISMORTUI LARGE RIBOSOMAL SUBUNIT AT 2.4 ANGSTROM RESOLUTION; 23S ribosomal RNA 1s72 9 122 2.4 RF00001 URS00003592C7_2238 15184028 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccggggaguacuggagugcgcgagccucugggaaacccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<<<<.....<<<<<<.<<....>>>>>>>>....>>>>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...(((((.....((((((.((....))))))))....)))))...))))))... REFINED CRYSTAL STRUCTURE OF THE HALOARCULA MARISMORTUI LARGE RIBOSOMAL SUBUNIT AT 2.4 ANGSTROM RESOLUTION; 5S ribosomal RNA 1sdr A 12 2.6 URS000080E1D4_32630 7540215 32630 uaaggaggugau ............ ............ CRYSTAL STRUCTURE OF AN RNA DODECAMER CONTAINING THE ESCHERICHIA COLI SHINE-DALGARNO SEQUENCE; RNA (5'-R(*UP*AP*AP*GP*GP*AP*GP*GP*UP*GP*AP*U)-3') 1sdr B 12 2.6 URS000022636A_32630 7540215 32630 aucaccuccuua ............ ............ CRYSTAL STRUCTURE OF AN RNA DODECAMER CONTAINING THE ESCHERICHIA COLI SHINE-DALGARNO SEQUENCE; RNA (5'-R(*AP*UP*CP*AP*CP*CP*UP*CP*CP*UP*UP*A)-3') 1sdr C 12 2.6 URS000080E1D4_32630 7540215 32630 uaaggaggugau ............ ............ CRYSTAL STRUCTURE OF AN RNA DODECAMER CONTAINING THE ESCHERICHIA COLI SHINE-DALGARNO SEQUENCE; RNA (5'-R(*UP*AP*AP*GP*GP*AP*GP*GP*UP*GP*AP*U)-3') 1sdr D 12 2.6 URS000022636A_32630 7540215 32630 aucaccuccuua ............ ............ CRYSTAL STRUCTURE OF AN RNA DODECAMER CONTAINING THE ESCHERICHIA COLI SHINE-DALGARNO SEQUENCE; RNA (5'-R(*AP*UP*CP*AP*CP*CP*UP*CP*CP*UP*UP*A)-3') 1sm1 0 2766 3.42 RF02540,RF02541 URS000080DEF1_1299 15059283 0003735 0005840 1299 ggucaagauaguaaggguccacgguggaugcccuggcgcuggagccgaugaaggacgcgauuaccugcgaaaagccccgacgagcuggagauacgcuuugacucggggauguccgaauggggaaacccaccucguaagagguauccgcaaggaugggaacucagggaacugaaacaucucaguaccugaaggagaagaaagagaauucgauuccguuaguagcggcgagcgaacccggaucagcccaaauucaaccccucaagccgaaguggcuggaaagcuacaccucagaaggugagaguccuguaggcgaacgagcgguugacuguaaggucguuguucgugaaacgaugacugaauccgcgcggaccaccgcgcaaggcuaaauacucccagugaccgauagcgcauaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaagagaaccugaaaccguggacuuacaagcagucauggcaccuuaugcguguuauggcgugccuauugaagcaugagccggcgacuuagaccugacgugcgagcuuaaguugaaaaacggaggcggagcgaaagcgaguccgaauagggcggcauuaguacgucgggcuagacucgaaaccaggugagcuaagcaugaccagguugaaacccccgugacagggggcggaggaccgaaccggugccugcugaaacagucucggaugaguuguguuuaggagugaaaagcuaaccgaaccuggagauagcuaguucuccccgaaauguauugagguacagccucggauguugaccauguccuguagagcacucacaaggcuaaaaccuuaugaaacuccgaaggggcacgcguuuaguccgggagugaggcugcgagagcuaacuuccguagccgagagggaaacaacccagaccaucagcuaaggucccuaaaugaucgcucagugguuaaggaugugucgucgcauagacagccaggagguuggcuuagaagcagccacccuucaaagagugcguaauagcucacuggucgagugacgaugcgccgaaaaugaucggggcucaagugaucuaccgaagcuauggauucaacucgcgaagcgaguugucugguaggggagcguucaguccgcggagaagccauaccggaaggagugguggagccgacugaagugcggaugccggcaugaguaacgauaaaagaagugagaaucuucuucgccguaaggacaaggguuccuggggaagggucguccgcccagggaaagucgggaccuaaggugaggccgaacggcgcagccgauggacagcaggucaagauuccugcaccgaucauguggagugauggagggacgcauuacgcuauccaaugccaagcuauggcuaugcugguugguacgcucaagggcgaucgggucagaaaaucuaccggucacaugccucagacguaucgggagcuuccucggaagcgaaguuggaaacgcgacggugccaagaaaagcuucuaaacguugaaacaugauugcccguaccgcaaaccgacacagguguccgagugucaaugcacuaaggcgcgcgagagaacccucguuaaggaacuuugcaaucucaccccguaacuucggaagaagggguccccacgcuucgcguggggcgcagugaauaggcccaggcgacuguuuaccaaaaucacagcacucugccaacacgaacaguggacguauagggugugacgccugcccggugccggaaggucaaguggagcggugcaagcugcgaaaugaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaggcguaacgaucugggcgcugucucaacgagggacucggugaaauugaauuggcuguaaagaugcggccuacccguagcaggacgaaaagaccccguggagcuuuacuauagucuggcauugggauucggguuucucugcguaggugggagaaacuggccggucgguggccacccugagaaacuuggauuucuaaccugaaaaaucacuuucggggaccgugcuuggcggguaguuugacuggggcggucgccucccaaaauguaacggaggcgcccaaaggucaccucaagacgguuggaaaucgucuguagagcgcaaagguagaagguggcuugacugcgagacugacacgucgagcagggaggaaacucgggcuuagugaaccggugguaccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagaguccauaucggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgcuacgggcgcaggagaauugaggggaguugcuccuaguacgagaggaccggagugaacggaccgcuggucucccugcugucguaccaacggcacaugcaggguagcuauguccggaacggauaaccgcugaaagcaucuaagcgggaagccagccccaagaugaguucucccacuguucagguaagacucccggaagaccaccggguuaagaggccaggcgugcacgcauagcaauguguucagcggacuggugcucaucagucgaggucuugacca <<<<<<<<.......<<<<<<<<<<.....<<.<<<<<<<<<<<<<......<<<<<<<((..((>>>>.....<<<<<<...<<.))..))..>>......>>>>>>...>>>....<<<....>>><<<<<....>>>>>.<<<....>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<......<<.....>>.....>>>>...<<<.....<<<<<<.<<<..<<<....<<<<......>>>>.((......<<<.....))>>>...>>>....>>>.>>>>>>......<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>>.............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>........<<<<<<<<<<.......>>>>>>>>>>...<.<........>.>.<<<<<<....<<<.<<<<<<<<<...<<<...<<......>>...>>>...<<....>>...<<.......>>.........>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<.....<<<<<......>>>>>......>>>...<<<..<.<<........>>.>.>>>....>>>>>>>>>>..<<.......>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<...<<<<.<<<<<<...<<<...<<<.<<<<......>>>>.>>>..>>.>...>>>>>>.>.>>>..>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<...<<<.......>>>...>>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>>..<.<<<.<<.....>>.>>>>.......>>>>>>..<<<<<<<.<.......<<<<<.<<....>>.>>>>>....>.>>>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<<..>>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<...<<...<<<<....<<<<..<<<..<<<<<.<<<<.<<...[[....>>>>>>..<<<<<.<<.<<<..<<<<<<.............>>>>>>.....>>>..>>>>>>>.....<<<<<....>>>>>....>>>>>...>>>...>>>>.........>>>>...>>......>>>>>>>>>>>>>..>>.....<<......>>.>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<....<....>.....>>>>><<<<<<<<...>>>>>>>>............<<<<<<<<<..<<...........>>..<<<<<<<.....<<<.....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<..<<<<<<...<<.<<<<.<....<<<<<.....<<<<<<..>>>>>>..>>>>>>.>>>>.>>...>>>>>>...<<<<<<........>>>>>>.....>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>..........(((......>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<..<<<<<<<.<.<<.......>>..>>>>>>>>...>>>.>.......<<.<<.<.<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>...>...>>..>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.]].>>>>>>...>>>>>...>>>>.>>>>>....<<....<<<<.............>>>>....>>..>>>>.......>>>>>>>..<<<..>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>>>. ((((((((.......(((((((((.....(((..((((((((((((......((((((.[[..[[[)))..]..((((((...((.]]..]]..))......))))))...)))....(((....)))(((((....)))))((((....))))))...((((((.....((..[.))......))))).).........((....))...(.((......((.]...)).....)).)...(((......(((((..((..(((...(((((......)))))[[(...).(((.....]])))...)))....))..))))).......((((.((((.......)))).))))......(((((..[[[[)))))..)))......)).)))))).))..............((....))....)).........((((....)))).............).....)))))))))........((((((((((.......)))))))))).[.(.(........).).((((((....(((.((((((((((..((....(((....)))....))...((....))...(........).........)))))))))))))..((.(...((((((...(.(((((..((..((((....(((((......)))))....).)))...((...(.((........)).)..))....))..))))).).((.......))......))))))......).))..((((((.....((((....))))..(((((((...(.(((.(((((....(((...(((.((((......)))).)))..)).)....))))).).))..).)))))).)...(((((((..(......)..)))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((.(((((((.......(((((.(((..(((.........)))..))).....(...((......)).).)))).)..))))))).)).))..........]]].)....))))))))))...)))))))...((((.(((...))).)))).......))))))(.(((((((.(.......((((..((....))..))))....).)))))))..).....))))))(......((.....((((((.......))))))((((....((((..((...((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((...((....(((....(((((.(((..(((((..(((.((...{{....)))))...(((((.(....(..((.(((....(.....)..))).)).....).....)))))).....(((((....)))))....)))))...)))..)))))(..).....)))....))......)))))))))))))..)).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(........((((....(....).....)))).((((((((...))))))))(...).......((((((.((...(...........)...(((((((.....(((.....))).......)))))))..((((.(((..((.((((..((....((...((.((....)).))...))....))))))...)))))(.((((.......)))).)........((..........(((((.......)))))..)..)....))))...))..)))))).)..))).)))))))).)))))).....).....(((((.....]..)))))..((((((((.(((..(......((((.((((((..(((((.(((..(((..(((((.(..((.((((.(....(((((......(.(.(()).).)...)))))).)))).))..).)))))...((.((((......)))).)).....)))..)))..)))))..(((......[)))((((((..(....)..])))))).[((...(((((((.(.((((((.......))))))...)..(][.[[[).....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....((((((..((..]]]]..)).))))))......}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......(.((.((.(((..(((((((((......))))))..))).(((((.....))))).....))).)..)...))..).....(((((((....))).))))....)...)))))))))))[...(((((((...((((..(.(((((.....(....)....))))).).(((((...(.((...(((((((.(((.}}.))).))...)))))...)).).)))))....((.(..((((.............))))...)))..))))..]....)))))))..(((..)))....(((((((((.......)))))....((((((((.(((.....((((....))))....)))..))))).)))...))))....)))))))). COMPLEX OF THE LARGE RIBOSOMAL SUBUNIT FROM DEINOCOCCUS RADIODURANS WITH QUINUPRISTIN AND DALFOPRISTIN; 23S RIBOSOMAL RNA 1sm1 9 118 3.42 RF00001 URS0000420396_1299 15059283 0003735 0005840 1299 cccccgugcccauagcacuguggaaccaccccaccccaugccgaacugggucgugaaacacagcagcgccaaugauacucggaccgcagggucccggaaaagucggucagcgcggggg <<<<<<<<<.....<<.<<<<<....<<<<<<<.............>>>>..>>>...>>>>>..>><<<.<.....<<.<<<<<....>>>>>.>>.....>.>>>..>>>>>>>>> (((((((((.....((.(((((.....(((((...............)))..))....)))))..)).((.......((.(((((....))))).)).......))...))))))))) COMPLEX OF THE LARGE RIBOSOMAL SUBUNIT FROM DEINOCOCCUS RADIODURANS WITH QUINUPRISTIN AND DALFOPRISTIN; 5S RIBOSOMAL RNA 1t0d A 17 2.2 URS000080DDA2_32630 15199571 32630 gguggugnagucgcugg ................. ................. Crystal Structure of 2-aminopurine labelled bacterial decoding site RNA; 5'-R(*GP*GP*UP*GP*GP*UP*GP*(MTU)P*AP*GP*UP*CP*GP*CP*UP*GP*G)-3' 1t0d B 16 2.2 URS000080E0EC_32630 15199571 32630 cagcgucacaccaccc ................ ................ Crystal Structure of 2-aminopurine labelled bacterial decoding site RNA; 5'-R(*CP*AP*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*AP*CP*CP*C)-3' 1t0d C 17 2.2 URS000080DDA2_32630 15199571 32630 gguggugnagucgcugg ................. ................. Crystal Structure of 2-aminopurine labelled bacterial decoding site RNA; 5'-R(*GP*GP*UP*GP*GP*UP*GP*(MTU)P*AP*GP*UP*CP*GP*CP*UP*GP*G)-3' 1t0d D 16 2.2 URS000080E0EC_32630 15199571 32630 cagcgucacaccaccc ................ ................ Crystal Structure of 2-aminopurine labelled bacterial decoding site RNA; 5'-R(*CP*AP*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*AP*CP*CP*C)-3' 1t0e A 18 1.7 URS000080E32C_32630 15199571 32630 gguggugaagucgcucgg .................. .................. Crystal Structure of 2-aminopurine labelled bacterial decoding site RNA; 5'-R(*GP*GP*UP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*CP*UP*CP*GP*G)-3' 1t0e C 17 1.7 URS000080DD8F_32630 15199571 32630 cgagcgucacaccaccc ................. ................. Crystal Structure of 2-aminopurine labelled bacterial decoding site RNA; 5'-R(*CP*GP*AP*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*AP*CP*CP*C)-3' 1t0k C 12 3.24 URS000080DF01_32630 15242593 32630 gaccggaguguc ............ ............ Joint X-ray and NMR Refinement of Yeast L30e-mRNA complex; 5'-R(*GP*AP*CP*CP*GP*GP*AP*GP*UP*GP*UP*CP*C)-3' 1t0k D 15 3.24 URS000080E32B_32630 15242593 32630 gacgcagagaugguc ............... ............... Joint X-ray and NMR Refinement of Yeast L30e-mRNA complex; 5'-R(*G*GP*AP*CP*GP*CP*AP*GP*AP*GP*AP*UP*GP*GP*UP*C)-3' 1tfw E 12 2.2 URS000080E084_32630 15295590 32630 gcggauccgcac ............ ............ How CCA is added to the 3' end of immature tRNA without the use of an oligonucleotide template; 5'-R(*GP*CP*GP*GP*AP*UP*CP*CP*GP*CP*AP*C)-3' 1tfw H 13 2.2 URS000080DED7_32630 15295590 32630 gcggauccgcacc ............. ............. How CCA is added to the 3' end of immature tRNA without the use of an oligonucleotide template; 5'-R(*GP*CP*GP*GP*AP*UP*CP*CP*GP*CP*AP*CP*C)-3' 1tfw F 12 2.2 URS000080E24F_32630 15295590 32630 gcggacccgcac ............ ............ How CCA is added to the 3' end of immature tRNA without the use of an oligonucleotide template; 5'-R(*GP*CP*GP*GP*AP*CP*CP*CP*GP*CP*AP*C)-3' 1tfw I 13 2.2 URS000080DED7_32630 15295590 32630 gcggauccgcacc ............. ............. How CCA is added to the 3' end of immature tRNA without the use of an oligonucleotide template; 5'-R(*GP*CP*GP*GP*AP*UP*CP*CP*GP*CP*AP*CP*C)-3' 1tfw G 13 2.2 URS000080DED7_32630 15295590 32630 gcggauccgcacc ............. ............. How CCA is added to the 3' end of immature tRNA without the use of an oligonucleotide template; 5'-R(*GP*CP*GP*GP*AP*UP*CP*CP*GP*CP*AP*CP*C)-3' 1tfw J 13 2.2 URS000080DE69_32630 15295590 32630 cgcggauccgcac ............. ............. How CCA is added to the 3' end of immature tRNA without the use of an oligonucleotide template; 5'-R(*CP*GP*CP*GP*GP*AP*UP*CP*CP*GP*CP*AP*C)-3' 1tfy E 13 3.2 URS000080DEA7_32630 15295590 32630 gcggauauccgcg ............. ............. How CCA is added to the 3' end of immature tRNA without the use of an oligonucleotide template; 5'-R(*GP*CP*GP*GP*AP*UP*AP*UP*CP*CP*GP*CP*G)-3' 1tfy H 14 3.2 URS000080E0BD_32630 15295590 32630 gcggauauccgcac .............. .............. How CCA is added to the 3' end of immature tRNA without the use of an oligonucleotide template; 5'-R(*GP*CP*GP*GP*AP*UP*AP*UP*CP*CP*GP*CP*AP*C)-3' 1tfy F 13 3.2 URS000080DEA7_32630 15295590 32630 gcggauauccgcg ............. ............. How CCA is added to the 3' end of immature tRNA without the use of an oligonucleotide template; 5'-R(*GP*CP*GP*GP*AP*UP*AP*UP*CP*CP*GP*CP*G)-3' 1tfy I 14 3.2 URS000080E0BD_32630 15295590 32630 gcggauauccgcac .............. .............. How CCA is added to the 3' end of immature tRNA without the use of an oligonucleotide template; 5'-R(*GP*CP*GP*GP*AP*UP*AP*UP*CP*CP*GP*CP*AP*C)-3' 1tfy G 11 3.2 URS000080E30A_32630 15295590 32630 cggauccgcac ........... ........... How CCA is added to the 3' end of immature tRNA without the use of an oligonucleotide template; 5'-R(*CP*GP*GP*AP*UP*CP*CP*GP*CP*AP*C)-3' 1tut A 11 NA URS000080E0BE_32630 15595837 32630 gaggaaggcga ........... ........... J4/5 Loop from the Candida albicans and Candida dubliniensis Group I Introns; 5'-R(*GP*AP*GP*GP*AP*AP*GP*GP*CP*GP*A)-3' 1tut B 11 NA URS000080E140_32630 15595837 32630 ucguuaaucuc ........... ........... J4/5 Loop from the Candida albicans and Candida dubliniensis Group I Introns; 5'-R(*UP*CP*GP*UP*UP*AP*AP*UP*CP*UP*C)-3' 1u1y S 16 2.85 URS000080DDEC_32630 15496523 32630 cggnggaucaccacgg <<..<<....>>.>>. ((..((....)).)). Crystal structure of a complex between WT bacteriophage MS2 coat protein and an F5 aptamer RNA stemloop with 2aminopurine substituted at the-10 position; 5'-R(*CP*CP*GP*GP*(2PR)P*GP*GP*AP*UP*CP*AP*CP*CP*AP*CP*GP*G)-3' 1u6b B 197 3.1 RF00028 URS000080E37C_32630 15175762 0000372 32630 ngccgugugccuugcgccgggaaaccacgcaagggauggugucaaauucggcgaaaccuaagcgcccgcccgggcguauggcaacgccgagccaagcuucgcagccauugcacuccggcugcgaugaagguguagagacuagacggcacccaccuaaggcaaacgcuauggugaaggcauaguccagggaguggcgn .........<<<<<<<..<<....>>.>>>>>>>...<<<<<<....<<<<<<...<<...<<<<<<....>>>>>>..>>...>>>>>><<<...<.<<<<<<<<..........>>>>>>>>.>..>>>.....(((((...>>>>>><<<<...<<<....>>>..>>>>......)))))............. .........(((((((..((....)).)))))))...((((((....((((((...((...((((((....))))))..))...))))))(((...(.((((((((..........)))))))).)..)))...[.[[[[[...))))))((((..((((....))).)))))......]]]]]]............ CRYSTAL STRUCTURE OF A SELF-SPLICING GROUP I INTRON WITH BOTH EXONS; 197-MER 1u6b C 22 3.1 URS000080E339_32630 15175762 32630 aagccacacaaaccagacggcc ...................... ...................... CRYSTAL STRUCTURE OF A SELF-SPLICING GROUP I INTRON WITH BOTH EXONS; 5'-R(*AP*AP*GP*CP*CP*AP*CP*AP*CP*AP*AP*AP*CP*CP*AP*GP*AP*CP*GP *GP*CP*C)-3' 1vq4 0 2754 2.7 RF02540,RF00002 URS000080DFCD_2238 16285925 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagccauggggagccgcacggaggcgaagaaccauggauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaaugugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucucgacgaagucucuuggaacagagcgugauacagggugacaaccccguacucgagaccaguacgacgugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccucgacgaaugaccgacgcgcgagcguccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucugcauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgccguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaaguaggggugaaaacuccuauggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucauaccgcaacucgacuaugacgaaaugggaaacggguuaauauucccgugccacuaugcagugaaaguugacgcccuggggucgaucacgcugggcaucgcccagucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcauaguguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcgaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggcuaucucagccggggacccggcgaagagugcaagagcaaaagauagcuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcugggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>..<<<<<<.....<<.....>>....>>>>>>..<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<..<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>..>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<..<<.........<<<<<....>>>>>.........>>..>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<.<<<.....>>>.>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<....<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>..>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......(..(.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......)..)...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((..((....(....(((((....))))).....)...))..))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).)........((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).).....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. The structure of the transition state analogue ""DAA"" bound to the large ribosomal subunit of Haloarcula marismortui; 23S ribosomal rna 1vq4 9 122 2.7 RF00001 URS00003592C7_2238 16285925 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccggggaguacuggagugcgcgagccucugggaaacccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<<<<.....<<<<<<.<<....>>>>>>>>....>>>>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...(((((.....((((((.((....))))))))....)))))...))))))... The structure of the transition state analogue ""DAA"" bound to the large ribosomal subunit of Haloarcula marismortui; 5S ribosomal RNA 1vq5 0 2754 2.6 RF02540,RF00002 URS000080DFCD_2238 16285925 0003735 0005840 2238 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The structure of the transition state analogue ""RAA"" bound to the large ribosomal subunit of haloarcula marismortui; 23S ribosomal rna 1vq5 9 122 2.6 RF00001 URS00003592C7_2238 16285925 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccggggaguacuggagugcgcgagccucugggaaacccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<<<<.....<<<<<<.<<....>>>>>>>>....>>>>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...(((((.....((((((.((....))))))))....)))))...))))))... The structure of the transition state analogue ""RAA"" bound to the large ribosomal subunit of haloarcula marismortui; 5S ribosomal RNA 1vq6 0 2754 2.7 RF02540,RF00002 URS000080DFCD_2238 16306996,16285925 0003735 0005840 2238 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..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>..<<<<<<.....<<.....>>....>>>>>>..<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<..<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>..>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<..<<.........<<<<<....>>>>>.........>>..>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<<<<<.....>>>>>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<....<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>..>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......(..(.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......)..)...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((..((....(....(((((....))))).....)...))..))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.((...(((.........)))...)).....(..(((......)))).)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...(((((((((((((.{{)))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. The structure of c-hpmn and CCA-PHE-CAP-BIO bound to the large ribosomal subunit of haloarcula marismortui; 23S ribosomal rna 1vq6 9 122 2.7 RF00001 URS00003592C7_2238 16306996,16285925 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccggggaguacuggagugcgcgagccucugggaaacccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<<<<.....<<<<<<.<<....>>>>>>>>....>>>>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...(((((.....((((((.((....))))))))....)))))...))))))... The structure of c-hpmn and CCA-PHE-CAP-BIO bound to the large ribosomal subunit of haloarcula marismortui; 5S ribosomal RNA 1vq7 0 2754 2.5 RF02540,RF00002 URS000080DFCD_2238 16306996,16285925 0003735 0005840 2238 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The structure of the transition state analogue ""DCA"" bound to the large ribosomal subunit of haloarcula marismortui; 23S ribosomal rna 1vq7 9 122 2.5 RF00001 URS00003592C7_2238 16306996,16285925 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccggggaguacuggagugcgcgagccucugggaaacccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<<<<.....<<<<<<.<<....>>>>>>>>....>>>>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...(((((.....((((((.((....))))))))....)))))...))))))... The structure of the transition state analogue ""DCA"" bound to the large ribosomal subunit of haloarcula marismortui; 5S ribosomal RNA 1vq8 0 2754 2.2 RF02540,RF00002 URS000080DFCD_2238 16285925 0003735 0005840 2238 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...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......(..(.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......)..)...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......(...(((.....))).............)).....)))))))))......(.((((((((((....((((((..((....(....(((((....))))).....)...))..))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. The structure of CCDA-PHE-CAP-BIO and the antibiotic sparsomycin bound to the large ribosomal subunit of haloarcula marismortui; 23S ribosomal rna 1vq8 9 122 2.2 RF00001 URS00003592C7_2238 16285925 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccggggaguacuggagugcgcgagccucugggaaacccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<<<<.....<<<<<<.<<....>>>>>>>>....>>>>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...(((((.....((((((.((....))))))))....)))))...))))))... The structure of CCDA-PHE-CAP-BIO and the antibiotic sparsomycin bound to the large ribosomal subunit of haloarcula marismortui; 5S ribosomal RNA 1vq9 0 2754 2.4 RF02540,RF00002 URS000080DFCD_2238 16285925 0003735 0005840 2238 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The structure of CCA-PHE-CAP-BIO and the antibiotic sparsomycin bound to the large ribosomal subunit of haloarcula marismortui; 23S ribosomal rna 1vq9 9 122 2.4 RF00001 URS00003592C7_2238 16285925 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccggggaguacuggagugcgcgagccucugggaaacccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<<<<.....<<<<<<.<<....>>>>>>>>....>>>>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...(((((.....((((((.((....))))))))....)))))...))))))... The structure of CCA-PHE-CAP-BIO and the antibiotic sparsomycin bound to the large ribosomal subunit of haloarcula marismortui; 5S ribosomal RNA 1vqk 0 2754 2.3 RF02540,RF00002 URS000080DFCD_2238 16285925 0003735 0005840 2238 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...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......(..(.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......)..)...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......(...(((.....))).............)).....)))))))))......(.((((((((((....((((((..((....(....(((((....))))).....)...))..))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. The structure of CCDA-PHE-CAP-BIO bound to the a site of the ribosomal subunit of haloarcula marismortui; 23S ribosomal rna 1vqk 9 122 2.3 RF00001 URS00003592C7_2238 16285925 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccggggaguacuggagugcgcgagccucugggaaacccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<<<<.....<<<<<<.<<....>>>>>>>>....>>>>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...(((((.....((((((.((....))))))))....)))))...))))))... The structure of CCDA-PHE-CAP-BIO bound to the a site of the ribosomal subunit of haloarcula marismortui; 5S ribosomal RNA 1vql 0 2754 2.3 RF02540,RF00002 URS000080DFCD_2238 16285925 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagccauggggagccgcacggaggcgaagaaccauggauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaaugugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucucgacgaagucucuuggaacagagcgugauacagggugacaaccccguacucgagaccaguacgacgugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccucgacgaaugaccgacgcgcgagcguccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucugcauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgccguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaaguaggggugaaaacuccuauggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucauaccgcaacucgacuaugacgaaaugggaaacggguuaauauucccgugccacuaugcagugaaaguugacgcccuggggucgaucacgcugggcaucgcccagucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcauaguguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcgaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggcuaucucagccggggacccggcgaagagugcaagagcaaaagauagcuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcugggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>...<<<<<.....<<.....>>....>>>>>...<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<..<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>..>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<..<<.........<<<<<....>>>>>.........>>..>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<...<<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>>.<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<.<<<.....>>>.>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<<...<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>.>>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......(..(.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......)..)...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......(...(((.....))).............)).....)))))))))......(.((((((((((....((((((..((....(....(((((....))))).....)...))..))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).)........((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).).....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. The structure of the transition state analogue ""DCSN"" bound to the large ribosomal subunit of haloarcula marismortui; 23S ribosomal rna 1vql 9 122 2.3 RF00001 URS00003592C7_2238 16285925 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccggggaguacuggagugcgcgagccucugggaaacccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<<.............>>>>..>>....>>>>>>.>><..<<<<<.....<<<<<<.<<....>>>>>>>>....>>>>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...(((((.....((((((.((....))))))))....)))))...))))))... The structure of the transition state analogue ""DCSN"" bound to the large ribosomal subunit of haloarcula marismortui; 5S ribosomal RNA 1vqm 0 2754 2.3 RF02540,RF00002 URS000080DFCD_2238 16285925 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagccauggggagccgcacggaggcgaagaaccauggauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaaugugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucucgacgaagucucuuggaacagagcgugauacagggugacaaccccguacucgagaccaguacgacgugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccucgacgaaugaccgacgcgcgagcguccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucugcauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgccguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaaguaggggugaaaacuccuauggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucauaccgcaacucgacuaugacgaaaugggaaacggguuaauauucccgugccacuaugcagugaaaguugacgcccuggggucgaucacgcugggcaucgcccagucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcauaguguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcgaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggcuaucucagccggggacccggcgaagagugcaagagcaaaagauagcuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcugggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>...<<<<<.....<<.....>>....>>>>>...<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<..<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>..>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<..<<.........<<<<<....>>>>>.........>>..>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<.<<<.....>>>.>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<<...<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>.>>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......(..(.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......)..)...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......(...(((.....))).............)).....)))))))))......(.((((((((((....((((((..((....(....(((((....))))).....)...))..))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).).....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. The structure of the transition state analogue ""DAN"" bound to the large ribosomal subunit of haloarcula marismortui; 23S ribosomal rna 1vqm 9 122 2.3 RF00001 URS00003592C7_2238 16285925 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccggggaguacuggagugcgcgagccucugggaaacccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<<.............>>>>..>>....>>>>>>.>><..<<<<<.....<<<<<<.<<....>>>>>>>>....>>>>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...(((((.....((((((.((....))))))))....)))))...))))))... The structure of the transition state analogue ""DAN"" bound to the large ribosomal subunit of haloarcula marismortui; 5S ribosomal RNA 1vqn 0 2754 2.4 RF02540,RF00002 URS000080DFCD_2238 16306996,16285925 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagccauggggagccgcacggaggcgaagaaccauggauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaaugugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucucgacgaagucucuuggaacagagcgugauacagggugacaaccccguacucgagaccaguacgacgugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccucgacgaaugaccgacgcgcgagcguccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucugcauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgccguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaaguaggggugaaaacuccuauggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucauaccgcaacucgacuaugacgaaaugggaaacggguuaauauucccgugccacuaugcagugaaaguugacgcccuggggucgaucacgcugggcaucgcccagucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcauaguguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcgaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggcuaucucagccggggacccggcgaagagugcaagagcaaaagauagcuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcugggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa 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...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......(..(.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......)..)...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......(...(((.....))).............)).....)))))))))......(.((((((((((....((((((..((....(....(((((....))))).....)...))..))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).)........((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).).....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. The structure of CC-HPMN AND CCA-PHE-CAP-BIO bound to the large ribosomal subunit of haloarcula marismortui; 23S ribosomal rna 1vqn 9 122 2.4 RF00001 URS00003592C7_2238 16306996,16285925 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccggggaguacuggagugcgcgagccucugggaaacccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<<<<.....<<<<<<.<<....>>>>>>>>....>>>>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...(((((.....((((((.((....))))))))....)))))...))))))... The structure of CC-HPMN AND CCA-PHE-CAP-BIO bound to the large ribosomal subunit of haloarcula marismortui; 5S ribosomal RNA 1vqo 0 2754 2.2 RF02540,RF00002 URS000080DFCD_2238 16285925 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagccauggggagccgcacggaggcgaagaaccauggauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaaugugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucucgacgaagucucuuggaacagagcgugauacagggugacaaccccguacucgagaccaguacgacgugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccucgacgaaugaccgacgcgcgagcguccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucugcauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgccguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaaguaggggugaaaacuccuauggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucauaccgcaacucgacuaugacgaaaugggaaacggguuaauauucccgugccacuaugcagugaaaguugacgcccuggggucgaucacgcugggcaucgcccagucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcauaguguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcgaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggcuaucucagccggggacccggcgaagagugcaagagcaaaagauagcuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcugggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa 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...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......(..(.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......)..)...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((..((....(....(((((....))))).....)...))..))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. The structure of CCPMN bound to the large ribosomal subunit haloarcula marismortui; 23S ribosomal rna 1vqo 9 122 2.2 RF00001 URS00003592C7_2238 16285925 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccggggaguacuggagugcgcgagccucugggaaacccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<<<<.....<<<<<<.<<....>>>>>>>>....>>>>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...(((((.....((((((.((....))))))))....)))))...))))))... The structure of CCPMN bound to the large ribosomal subunit haloarcula marismortui; 5S ribosomal RNA 1vqp 0 2754 2.25 RF02540,RF00002 URS000080DFCD_2238 16285925 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagccauggggagccgcacggaggcgaagaaccauggauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaaugugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucucgacgaagucucuuggaacagagcgugauacagggugacaaccccguacucgagaccaguacgacgugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccucgacgaaugaccgacgcgcgagcguccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucugcauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgccguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaaguaggggugaaaacuccuauggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucauaccgcaacucgacuaugacgaaaugggaaacggguuaauauucccgugccacuaugcagugaaaguugacgcccuggggucgaucacgcugggcaucgcccagucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcauaguguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcgaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggcuaucucagccggggacccggcgaagagugcaagagcaaaagauagcuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcugggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>...<<<<<.....<<.....>>....>>>>>...<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<..<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>..>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<..<<.........<<<<<....>>>>>.........>>..>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<...<<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>>.<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<.<<<.....>>>.>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<<...<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>.>>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......(..(.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......)..)...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......(...(((.....))).............)).....)))))))))......(.((((((((((....((((((..((....(....(((((....))))).....)...))..))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).)........((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).).....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. The structure of the transition state analogue ""RAP"" bound to the large ribosomal subunit of haloarcula marismortui; 23S ribosomal rna 1vqp 9 122 2.25 RF00001 URS00003592C7_2238 16285925 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccggggaguacuggagugcgcgagccucugggaaacccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<<<<.....<<<<<<.<<....>>>>>>>>....>>>>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...(((((.....((((((.((....))))))))....)))))...))))))... The structure of the transition state analogue ""RAP"" bound to the large ribosomal subunit of haloarcula marismortui; 5S ribosomal RNA 1vvj QA 1500 3.44 RF00177,RF01959,RF01960 URS000080E226_300852 25128388 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggggucuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<...>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>....<<<<.<<<<<....>>>>>.>>>>...<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<.<..<<<<<<<.<..<<<......>>>.....>.>>>>>>>...>.......<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<......>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((((..(((((((....)))))))...((((....))))..))))))))).((.(((..(((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....))))))).....(((((....)))))........)))).....).).)))...))))))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Crystal Structure of Frameshift Suppressor tRNA SufA6 bound to Codon CCC-G on the Ribosome; 16S rRNA 1vvj QV 77 3.44 RF00005 URS000041AF00_1110693 25128388 0030533 0006412 1110693 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal Structure of Frameshift Suppressor tRNA SufA6 bound to Codon CCC-G on the Ribosome; P-site tRNA fMet 1vvj QY 14 3.44 25128388 32630 ucguucggngacga <<<<......>>>> (((........))) Crystal Structure of Frameshift Suppressor tRNA SufA6 bound to Codon CCC-G on the Ribosome; messenger RNA 1vvj RA 2883 3.44 RF02540,RF02541,RF00002 URS000080DFFB_300852 25128388 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<..>>>>>>.>>....<<<<<.....<<....>>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<..>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<<..>>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<<.....>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[[)))...].((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((..)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....()....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((...((((((......)))).))...))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......(((((.(((..(((.........)))..))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(((((((...(((......(((((.(((....))))))))...)))..))))).)).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........(((((..(((......((((((((....))))))))...)))............)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.((((.....))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal Structure of Frameshift Suppressor tRNA SufA6 bound to Codon CCC-G on the Ribosome; 23S rRNA 1vvj RB 120 3.44 RF00001 URS00005F2F4B_300852 25128388 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> (((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).))))))))))) Crystal Structure of Frameshift Suppressor tRNA SufA6 bound to Codon CCC-G on the Ribosome; 5S rRNA 1vvj XA 1501 3.44 RF00177,RF01959,RF01960 URS000080E226_300852 25128388 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>....<<<<.<<<<<....>>>>>.>>>>...<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<......>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((())))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...((((((((..(((((((....)))))))...((((....))))..))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Crystal Structure of Frameshift Suppressor tRNA SufA6 bound to Codon CCC-G on the Ribosome; 16S rRNA 1vvj XV 77 3.44 RF00005 URS000041AF00_1110693 25128388 0030533 0006412 1110693 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal Structure of Frameshift Suppressor tRNA SufA6 bound to Codon CCC-G on the Ribosome; P-site tRNA fMet 1vvj XY 14 3.44 25128388 32630 ucguucggngacga <<<<......>>>> (((........))) Crystal Structure of Frameshift Suppressor tRNA SufA6 bound to Codon CCC-G on the Ribosome; messenger RNA 1vvj YA 2882 3.44 RF02540,RF02541,RF00002 URS000080DFFB_300852 25128388 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<..>...>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<<<<<<<<...<<.......>>...>>>>>>>..>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<.....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[[)))...].((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....()....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((.(.((((((......)))).)))..))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......(((((.(((..(((.........)))..))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((.(((((((.((.....)))))))))......))))))))..)))(....(((....)))......))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........(((((..(((......((((((((....))))))))...)))............)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.((((.....))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal Structure of Frameshift Suppressor tRNA SufA6 bound to Codon CCC-G on the Ribosome; 23S rRNA 1vvj YB 120 3.44 RF00001 URS00005F2F4B_300852 25128388 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> (((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).))))))))))) Crystal Structure of Frameshift Suppressor tRNA SufA6 bound to Codon CCC-G on the Ribosome; 5S rRNA 1vy4 AA 1497 2.6 RF00177,RF01959,RF01960 URS000080DFED_300852 25132179 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccucgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<...>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>.....<......>....>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((((((....))))))).)))))......(((......((((((((..((...(((((((.(((((....(.((((....)))).).....)))))....((((.(((((....))))).))))...(((.....))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((...))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((.(((....))).)))....(((....)))....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.. Crystal structure of the Thermus thermophilus 70S ribosome in the pre-attack state of peptide bond formation containing acylated tRNA-substrates in the A and P sites.; 16S Ribosomal RNA 1vy4 AV 13 2.6 25132179 32630 aaaaauguucuaa ............. ............. Crystal structure of the Thermus thermophilus 70S ribosome in the pre-attack state of peptide bond formation containing acylated tRNA-substrates in the A and P sites.; mRNA 1vy4 AW 74 2.6 RF00005 URS00005AA258_562 25132179 0030533 0006412 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcaccn <<<<<<<..<<<<......>>>><<<<<<<.....>>>>>>.>...<<<<<.......>>>>>>>>>>>>.... .((((((..((((......)))).((((.........)))).....(((((.......)))))))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in the pre-attack state of peptide bond formation containing acylated tRNA-substrates in the A and P sites.; A-site tRNA 1vy4 AX 76 2.6 RF00005 URS000041AF00_562 25132179 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaaccn <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in the pre-attack state of peptide bond formation containing acylated tRNA-substrates in the A and P sites.; P-site tRNA 1vy4 AY 74 2.6 RF00005 URS00005AA258_562 25132179 0030533 0006412 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[..)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of the Thermus thermophilus 70S ribosome in the pre-attack state of peptide bond formation containing acylated tRNA-substrates in the A and P sites.; E-site tRNA 1vy4 BA 2819 2.6 RF02540,RF02541,RF00002 URS00001698E8_300852 25132179 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagcggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<....<<<<<......>>>>.>....>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<...>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<..<<....>>..>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((...((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((.(..(.(((......)))...))..))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.........)))))))))).))..........]]].)....))))))))))...)))))))(((((((.......)))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((.((((((.(......[..(((((..(((......((((.(((....))).))))...)))..........].)))))).)))))).)))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((.))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal structure of the Thermus thermophilus 70S ribosome in the pre-attack state of peptide bond formation containing acylated tRNA-substrates in the A and P sites.; 23S Ribosomal RNA 1vy4 BB 120 2.6 RF00001 URS000080DEE8_300852 25132179 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>. .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the Thermus thermophilus 70S ribosome in the pre-attack state of peptide bond formation containing acylated tRNA-substrates in the A and P sites.; 5S Ribosomal RNA 1vy4 CA 1503 2.6 RF00177,RF01959,RF01960 URS000080DFED_300852 25132179 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggau .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>.....<......>.....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((((..((((((......)))))).....((....))....))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(.(((((..(((..(((.....))))))...))))).)..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}... Crystal structure of the Thermus thermophilus 70S ribosome in the pre-attack state of peptide bond formation containing acylated tRNA-substrates in the A and P sites.; 16S Ribosomal RNA 1vy4 CV 12 2.6 25132179 32630 aaaauguucuaa ............ ............ Crystal structure of the Thermus thermophilus 70S ribosome in the pre-attack state of peptide bond formation containing acylated tRNA-substrates in the A and P sites.; mRNA 1vy4 CW 72 2.6 RF00005 URS00005AA258_562 25132179 0030533 0006412 562 cccgganagcucagggagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcaccn <<<<<<..<<<<.....>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>..... ((.(((..((((...[.)))).((((.........)))).....(((((..]....)))))))).))..... Crystal structure of the Thermus thermophilus 70S ribosome in the pre-attack state of peptide bond formation containing acylated tRNA-substrates in the A and P sites.; A-site tRNA 1vy4 CX 76 2.6 RF00005 URS000041AF00_562 25132179 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaaccn <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in the pre-attack state of peptide bond formation containing acylated tRNA-substrates in the A and P sites.; P-site tRNA 1vy4 CY 73 2.6 RF00005 URS00005AA258_562 25132179 0030533 0006412 562 gcccgganagcucagggagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<.....>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....)))).((((.........)))).....((.((.......)).))))))))).... Crystal structure of the Thermus thermophilus 70S ribosome in the pre-attack state of peptide bond formation containing acylated tRNA-substrates in the A and P sites.; E-site tRNA 1vy4 DA 2800 2.6 RF02540,RF02541,RF00002 URS00001698E8_300852 25132179 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<..>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<.<......<<<<<<<<....>>>>>>>>...>.>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...((((((((.....))))))))....{.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).))))....(((((((((.[.....)))))))))....}.(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((()))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((.(....(.(......).)....)..))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((((((()))))))))).))..........]]].)....))))))))))...)))))))(((((((())))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........(((((...((.......((((.((....)).))))....)).............)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(((...)).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal structure of the Thermus thermophilus 70S ribosome in the pre-attack state of peptide bond formation containing acylated tRNA-substrates in the A and P sites.; 23S Ribosomal RNA 1vy4 DB 120 2.6 RF00001 URS000080DEE8_300852 25132179 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<.....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>..>>>>>>>>>. .(((((((((.....((((((.(....(((((((...(.....)...))))..)))...).)))).))(((.......((((((((....)))))))).......)))..))))))))). Crystal structure of the Thermus thermophilus 70S ribosome in the pre-attack state of peptide bond formation containing acylated tRNA-substrates in the A and P sites.; 5S Ribosomal RNA 1vy5 AA 1498 2.55 RF00177,RF01959,RF01960 URS000080DFED_300852 25132179 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccucgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggau .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<...>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>.....<......>....>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((..)))))))).)))))......(((......((((((((..((...(((((((.(((((....(.((.(....).)).).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((...))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((...(((((((....)))))))....(((....)))....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}... Crystal structure of the Thermus thermophilus 70S ribosome in the post-catalysis state of peptide bond formation containing dipeptydil-tRNA in the A site and deacylated tRNA in the P site.; 16S Ribosomal RNA 1vy5 AV 13 2.55 25132179 32630 aaaaauguucuaa ............. ............. Crystal structure of the Thermus thermophilus 70S ribosome in the post-catalysis state of peptide bond formation containing dipeptydil-tRNA in the A site and deacylated tRNA in the P site.; mRNA 1vy5 AW 74 2.55 RF00005 URS00005AA258_562 25132179 0030533 0006412 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcaccn <<<<<<<..<<<<......>>>><<<<<<<.....>>>>>>.>...<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[..)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of the Thermus thermophilus 70S ribosome in the post-catalysis state of peptide bond formation containing dipeptydil-tRNA in the A site and deacylated tRNA in the P site.; A-site tRNA 1vy5 AX 76 2.55 RF00005 URS000041AF00_562 25132179 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in the post-catalysis state of peptide bond formation containing dipeptydil-tRNA in the A site and deacylated tRNA in the P site.; P-site tRNA 1vy5 AY 74 2.55 RF00005 URS00005AA258_562 25132179 0030533 0006412 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<......>>>>.<<<<<<<...>>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((......)))).((((.........)))).....(((((.......)))))))))))).... Crystal structure of the Thermus thermophilus 70S ribosome in the post-catalysis state of peptide bond formation containing dipeptydil-tRNA in the A site and deacylated tRNA in the P site.; E-site tRNA 1vy5 BA 2819 2.55 RF02540,RF02541,RF00002 URS00001698E8_300852 25132179 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagcggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<...>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<.<......>.>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((...((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....((((((((..[......))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((.(..(.(((......)))...))..)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.........)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((.((((((.(......[..(((((..(((......((((.(((....))).))))...)))..........].)))))).)))))).)))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..((((.))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the Thermus thermophilus 70S ribosome in the post-catalysis state of peptide bond formation containing dipeptydil-tRNA in the A site and deacylated tRNA in the P site.; 23S Ribosomal RNA 1vy5 BB 120 2.55 RF00001 URS000080DEE8_300852 25132179 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the Thermus thermophilus 70S ribosome in the post-catalysis state of peptide bond formation containing dipeptydil-tRNA in the A site and deacylated tRNA in the P site.; 5S Ribosomal RNA 1vy5 CA 1503 2.55 RF00177,RF01959,RF01960 URS000080DFED_300852 25132179 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggau .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<...<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>...>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<......>>....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<..<.<<<<<<<........>>>>>>>>...>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((((..(((((((....))))))).....((....))....))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(.(((((..(((..(((.....))))))...))))).)..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}... Crystal structure of the Thermus thermophilus 70S ribosome in the post-catalysis state of peptide bond formation containing dipeptydil-tRNA in the A site and deacylated tRNA in the P site.; 16S Ribosomal RNA 1vy5 CV 12 2.55 25132179 32630 aaaauguucuaa ............ ............ Crystal structure of the Thermus thermophilus 70S ribosome in the post-catalysis state of peptide bond formation containing dipeptydil-tRNA in the A site and deacylated tRNA in the P site.; mRNA 1vy5 CW 72 2.55 RF00005 URS00005AA258_562 25132179 0030533 0006412 562 cccgganagcucagggagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcaccn <<<<<<..<<<<.....>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((...[.)))).((((.........)))).....(((((..]....)))))))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in the post-catalysis state of peptide bond formation containing dipeptydil-tRNA in the A site and deacylated tRNA in the P site.; A-site tRNA 1vy5 CX 76 2.55 RF00005 URS000041AF00_562 25132179 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in the post-catalysis state of peptide bond formation containing dipeptydil-tRNA in the A site and deacylated tRNA in the P site.; P-site tRNA 1vy5 CY 73 2.55 RF00005 URS00005AA258_562 25132179 0030533 0006412 562 gcccgganagcucagggagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<.....>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....)))).((((.........)))).....((.((.......)).))))))))).... Crystal structure of the Thermus thermophilus 70S ribosome in the post-catalysis state of peptide bond formation containing dipeptydil-tRNA in the A site and deacylated tRNA in the P site.; E-site tRNA 1vy5 DA 2800 2.55 RF02540,RF02541,RF00002 URS00001698E8_300852 25132179 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<..>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((()))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((....(.(.(......).)..)....)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((((((()))))))))).))..........]]].)....))))))))))...)))))))(((((((())))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........(((((..(((......((((((((....))))))))...)))............)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....))))))).(((.))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the Thermus thermophilus 70S ribosome in the post-catalysis state of peptide bond formation containing dipeptydil-tRNA in the A site and deacylated tRNA in the P site.; 23S Ribosomal RNA 1vy5 DB 120 2.55 RF00001 URS000080DEE8_300852 25132179 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>. .((((((((((....((((((.(....(((((((...(.....)...))))..)))...).)))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the Thermus thermophilus 70S ribosome in the post-catalysis state of peptide bond formation containing dipeptydil-tRNA in the A site and deacylated tRNA in the P site.; 5S Ribosomal RNA 1vy6 AA 1498 2.9 RF00177,RF01959,RF01960 URS000080DFED_300852 25132179 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccucgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggau .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<..[.>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<...>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>.......]..<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<.<......>.>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((..)))))))).)))))......(((......((((((((..((...(((((((.((((.....((((((....))))))......))))....((.(...(((....)))...).))...(((.....))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((...))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((((((....)))))))...((((....))))...)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}... Crystal structure of the Thermus thermophilus 70S ribosome in the pre-attack state of peptide bond formation containing short substrate-mimic Cytidine-Puromycin in the A site and acylated tRNA in the P site.; 16S Ribosomal RNA 1vy6 AV 13 2.9 25132179 32630 aaaaauguucuaa ............. ............. Crystal structure of the Thermus thermophilus 70S ribosome in the pre-attack state of peptide bond formation containing short substrate-mimic Cytidine-Puromycin in the A site and acylated tRNA in the P site.; mRNA 1vy6 AX 76 2.9 RF00005 URS000041AF00_562 25132179 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaaccn <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in the pre-attack state of peptide bond formation containing short substrate-mimic Cytidine-Puromycin in the A site and acylated tRNA in the P site.; P-site tRNA 1vy6 BA 2819 2.9 RF02540,RF02541,RF00002 URS00001698E8_300852 25132179 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagcggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<...>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<...<......>...>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<...>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((...((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((..)))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((....(.(((......)))...)...))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.........)))))))))).))..........]]].)....))))))))))...)))))))(((((((.......)))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(......[..(((((..(((......(((....(....)....)))...)))..........].)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..((((.))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the Thermus thermophilus 70S ribosome in the pre-attack state of peptide bond formation containing short substrate-mimic Cytidine-Puromycin in the A site and acylated tRNA in the P site.; 23S Ribosomal RNA 1vy6 BB 120 2.9 RF00001 URS000080DEE8_300852 25132179 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the Thermus thermophilus 70S ribosome in the pre-attack state of peptide bond formation containing short substrate-mimic Cytidine-Puromycin in the A site and acylated tRNA in the P site.; 5S Ribosomal RNA 1vy6 CA 1503 2.9 RF00177,RF01959,RF01960 URS000080DFED_300852 25132179 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggau .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<.<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<......>>....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>..>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>.... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(.((((((((..)))))))).).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((.((...)).)))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...((((((......))))))....(((....)))....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(.(((((..(((..(((.....))))))...))))).)..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}... Crystal structure of the Thermus thermophilus 70S ribosome in the pre-attack state of peptide bond formation containing short substrate-mimic Cytidine-Puromycin in the A site and acylated tRNA in the P site.; 16S Ribosomal RNA 1vy6 CV 12 2.9 25132179 32630 aaaauguucuaa ............ ............ Crystal structure of the Thermus thermophilus 70S ribosome in the pre-attack state of peptide bond formation containing short substrate-mimic Cytidine-Puromycin in the A site and acylated tRNA in the P site.; mRNA 1vy6 CX 76 2.9 RF00005 URS000041AF00_562 25132179 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaaccn <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in the pre-attack state of peptide bond formation containing short substrate-mimic Cytidine-Puromycin in the A site and acylated tRNA in the P site.; P-site tRNA 1vy6 DA 2800 2.9 RF02540,RF02541,RF00002 URS00001698E8_300852 25132179 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>....<<<<<.....<......>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<..>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<.<......<<<<<<<<....>>>>>>>>...>.>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((..))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((.(((...(((...(((.((((......((........)).......)))).)))..)).)...))).)))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((((((()))))))))).))..........]]].)....))))))))))...)))))))(((((((())))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((....))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((...........(((((...((......(((((.((....)).)))))...)).............)))))..))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))((((.))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal structure of the Thermus thermophilus 70S ribosome in the pre-attack state of peptide bond formation containing short substrate-mimic Cytidine-Puromycin in the A site and acylated tRNA in the P site.; 23S Ribosomal RNA 1vy6 DB 120 2.9 RF00001 URS000080DEE8_300852 25132179 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>>. .((((((((((....((((((.(....(((((((...(.....)...))))..)))...).)))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the Thermus thermophilus 70S ribosome in the pre-attack state of peptide bond formation containing short substrate-mimic Cytidine-Puromycin in the A site and acylated tRNA in the P site.; 5S Ribosomal RNA 1vy7 AA 1498 2.8 RF00177,RF01959,RF01960 URS000080DFED_300852 25132179 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccucgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggau .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<.....<<<<<......>>>>>......>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<..[.>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<...>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>.......]..<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>.....<......>....>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((..)))))))).)))))......(((......((((((((..((...(((((((.(((.(.....(((((....))))).......))))....((((.(((((....))))).))))....(((...)))..)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((...))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......(((.((.....)).)))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((.((......)).)))....(((....)))....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...))))))).....(((........)))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}... Crystal structure of the Thermus thermophilus 70S ribosome in the pre-attack state of peptide bond formation containing short substrate-mimic Cytidine-Cytidine-Puromycin in the A site and acylated tRNA in the P site.; 16S Ribosomal RNA 1vy7 AV 13 2.8 25132179 32630 aaaaauguucuaa ............. ............. Crystal structure of the Thermus thermophilus 70S ribosome in the pre-attack state of peptide bond formation containing short substrate-mimic Cytidine-Cytidine-Puromycin in the A site and acylated tRNA in the P site.; mRNA 1vy7 AX 76 2.8 RF00005 URS000041AF00_562 25132179 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaaccn <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in the pre-attack state of peptide bond formation containing short substrate-mimic Cytidine-Cytidine-Puromycin in the A site and acylated tRNA in the P site.; P-site tRNA 1vy7 BA 2819 2.8 RF02540,RF02541,RF00002 URS00001698E8_300852 25132179 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagcggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<...>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<.......<<<<..<......>..>>>>....>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...((((((((.....))))))))....{.(((((((((...((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).))))....(((((((((.[.....)))))))))....}.(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((.(....(((......)))....)..)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.........)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((.(((.(.((((((.(......[..(((((..((.......((((..((....))..))))....))..........].)))))).)))))).).))).)))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..((((.))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the Thermus thermophilus 70S ribosome in the pre-attack state of peptide bond formation containing short substrate-mimic Cytidine-Cytidine-Puromycin in the A site and acylated tRNA in the P site.; 23S Ribosomal RNA 1vy7 BB 120 2.8 RF00001 URS000080DEE8_300852 25132179 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>. .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the Thermus thermophilus 70S ribosome in the pre-attack state of peptide bond formation containing short substrate-mimic Cytidine-Cytidine-Puromycin in the A site and acylated tRNA in the P site.; 5S Ribosomal RNA 1vy7 CA 1503 2.8 RF00177,RF01959,RF01960 URS000080DFED_300852 25132179 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggau .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<((....<<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>....<<......>>...>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>.... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((...(((....)))...))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(.(((....)))..))))).)).))))))...(((......((((....)))).....)).)....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......(..(((.....)))..)....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((.....)))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((.((((...((((((......))))))....(((....)))....)))).))).((.((....((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(.(((((..(((..(((.....))))))...))))).)..(..(((((....))))).....)..)))).....).).)))...))..))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}... Crystal structure of the Thermus thermophilus 70S ribosome in the pre-attack state of peptide bond formation containing short substrate-mimic Cytidine-Cytidine-Puromycin in the A site and acylated tRNA in the P site.; 16S Ribosomal RNA 1vy7 CX 76 2.8 RF00005 URS000041AF00_562 25132179 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaaccn <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......)))))......((((..]....)))).))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in the pre-attack state of peptide bond formation containing short substrate-mimic Cytidine-Cytidine-Puromycin in the A site and acylated tRNA in the P site.; P-site tRNA 1vy7 DA 2800 2.8 RF02540,RF02541,RF00002 URS00001698E8_300852 25132179 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<<....<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<....<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.....>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<..>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<..>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((()))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((....(.(((......)))..)....)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((((((..))))))))).))..........]]].)....))))))))))...)))))))(((((((..)))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........(((((...((.......((((.((....)).))))....)).............)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((.(.........).)))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))...(.).......(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the Thermus thermophilus 70S ribosome in the pre-attack state of peptide bond formation containing short substrate-mimic Cytidine-Cytidine-Puromycin in the A site and acylated tRNA in the P site.; 23S Ribosomal RNA 1vy7 DB 120 2.8 RF00001 URS000080DEE8_300852 25132179 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>. .(.((((((((....((((((.(....((..(((...(.....)...)))....))...).)))).))(((.......((((((((....)))))))).......))).)))))))).). Crystal structure of the Thermus thermophilus 70S ribosome in the pre-attack state of peptide bond formation containing short substrate-mimic Cytidine-Cytidine-Puromycin in the A site and acylated tRNA in the P site.; 5S Ribosomal RNA 1w2b 0 2754 3.5 RF02540,RF00002 URS000080DFCD_2238 15334087 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagccauggggagccgcacggaggcgaagaaccauggauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaaugugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucucgacgaagucucuuggaacagagcgugauacagggugacaaccccguacucgagaccaguacgacgugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccucgacgaaugaccgacgcgcgagcguccaguaagacucacgggaagccgauguucugucguacguuuugaaaaacgagccagggagugugucugcauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgccguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaaguaggggugaaaacuccuauggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucauaccgcaacucgacuaugacgaaaugggaaacggguuaauauucccgugccacuaugcagugaaaguugacgcccuggggucgaucacgcugggcaucgcccagucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcauaguguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcgaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggcuaucucagccggggacccggcgaagagugcaagagcaaaagauagcuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugagguuguucgccuauuaaaggaggucgugagcuggguuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>..<<<<<<.....<<.....>>....>>>>>>..<<<...<<<<..<<<<....>>>>....>>>>....<<<<<<<<......<..<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>..>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<..<<.........<<<<<....>>>>>.........>>..>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<<<<<.....>>>>>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<<...<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>>>>>>..<<<.......>>>.>>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......(..(.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......)..)...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((..((....(....(((((....))))).....)...))..))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....)).....((((...((((..))))...)))).((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..((((.......))))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Trigger Factor ribosome binding domain in complex with 50S; 23S RRNA 1w2b 9 122 3.5 RF00001 URS00003592C7_2238 15334087 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccggggaguacuggagugcgcgagccucugggaaacccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<<<<.....<<<<<<.<<....>>>>>>>>....>>>>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...(((((.....((((((.((....))))))))....)))))...))))))... Trigger Factor ribosome binding domain in complex with 50S; 5S RRNA 1wsu E 22 2.3 URS000080E0A3_32630 15665870 32630 ggcguugccggucggcaacgcc <<<<<<<<<<..>>>>>>>>>> ((((.(((((..))))).)))) C-terminal domain of elongation factor selB complexed with SECIS RNA; 5'-R(*GP*GP*CP*GP*UP*UP*GP*CP*CP*GP*GP*UP*CP*U*GP*GP*CP*AP*AP*CP*GP*CP*C)-3' 1wsu G 21 2.3 URS000080E0A3_32630 15665870 32630 ggcguugccgguggcaacgcc <<<<<<<<<...>>>>>>>>> ((((.((((...)))).)))) C-terminal domain of elongation factor selB complexed with SECIS RNA; 5'-R(*GP*GP*CP*GP*UP*UP*GP*CP*CP*GP*GP*UP*CP*U*GP*GP*CP*AP*AP*CP*GP*CP*C)-3' 1wvd A 23 2.93 URS000080E21C_32630 12736317 32630 cuugcugaggugcacacagcaag ....................... ....................... HIV-1 Dis(Mal) Duplex CoCl2-Soaked; 5'-R(*CP*UP*UP*GP*CP*UP*GP*AP*GP*GP*UP*GP*CP*AP*CP*AP*CP*AP*GP*CP*AP*AP*G)-3' 1wvd B 23 2.93 URS000080E21C_32630 12736317 32630 cuugcugaggugcacacagcaag ....................... ....................... HIV-1 Dis(Mal) Duplex CoCl2-Soaked; 5'-R(*CP*UP*UP*GP*CP*UP*GP*AP*GP*GP*UP*GP*CP*AP*CP*AP*CP*AP*GP*CP*AP*AP*G)-3' 1x9c A 13 2.19 URS000080E09E_32630 16262240 32630 ucccnguccaccg ............. ............. An all-RNA Hairpin Ribozyme with mutation U39C; 5'-R(*UP*CP*CP*CP*(A2M)P*GP*UP*CP*CP*AP*CP*CP*G)-3' 1x9c B 12 2.19 URS000080DF3F_32630 16262240 32630 cggugagaaggg ............ ............ An all-RNA Hairpin Ribozyme with mutation U39C; 5'-R(*CP*GP*GP*UP*GP*AP*GP*AP*AP*GP*GP*G)-3' 1x9c C 17 2.19 URS000080DEF8_32630 16262240 32630 ggcagagaaacacacga ................. ................. An all-RNA Hairpin Ribozyme with mutation U39C; 5'-R(*GP*GP*CP*AP*GP*AP*GP*AP*AP*AP*CP*AP*CP*AP*CP*GP*A)-3' 1x9c D 19 2.19 URS000080E34C_32630 16262240 32630 ucgugguacauuaccugcc ................... ................... An all-RNA Hairpin Ribozyme with mutation U39C; 5'-R(*UP*CP*GP*UP*GP*GP*UP*AP*CP*AP*UP*UP*AP*CP*CP*UP*GP*CP*C)-3' 1x9k A 13 3.17 URS000080E08A_32630 16262240 32630 ucgcaguccuauu ............. ............. An all-RNA Hairpin Ribozyme with mutation U39C; 5'-R(*UP*CP*GP*CP*AP*GP*UP*CP*CP*UP*AP*UP*U)-3' 1x9k B 13 3.17 URS000080DD37_32630 16262240 32630 aauagagaagcga ............. ............. An all-RNA Hairpin Ribozyme with mutation U39C; 5'-R(*AP*AP*UP*AP*GP*AP*GP*AP*AP*GP*CP*GP*A)-3' 1x9k C 17 3.17 URS000080DEF8_32630 16262240 32630 ggcagagaaacacacga ................. ................. An all-RNA Hairpin Ribozyme with mutation U39C; 5'-R(*GP*GP*CP*AP*GP*AP*GP*AP*AP*AP*CP*AP*CP*AP*CP*GP*A)-3' 1x9k D 19 3.17 URS000080E34C_32630 16262240 32630 ucgugguacauuaccugcc ................... ................... An all-RNA Hairpin Ribozyme with mutation U39C; 5'-R(*UP*CP*GP*UP*GP*GP*UP*AP*CP*AP*UP*UP*AP*CP*CP*UP*GP*CP*C)-3' 1xbp 0 2766 3.5 RF02540,RF02541 URS000080DEF1_1299 15554968 0003735 0005840 1299 ggucaagauaguaaggguccacgguggaugcccuggcgcuggagccgaugaaggacgcgauuaccugcgaaaagccccgacgagcuggagauacgcuuugacucggggauguccgaauggggaaacccaccucguaagagguauccgcaaggaugggaacucagggaacugaaacaucucaguaccugaaggagaagaaagagaauucgauuccguuaguagcggcgagcgaacccggaucagcccaaauucaaccccucaagccgaaguggcuggaaagcuacaccucagaaggugagaguccuguaggcgaacgagcgguugacuguaaggucguuguucgugaaacgaugacugaauccgcgcggaccaccgcgcaaggcuaaauacucccagugaccgauagcgcauaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaagagaaccugaaaccguggacuuacaagcagucauggcaccuuaugcguguuauggcgugccuauugaagcaugagccggcgacuuagaccugacgugcgagcuuaaguugaaaaacggaggcggagcgaaagcgaguccgaauagggcggcauuaguacgucgggcuagacucgaaaccaggugagcuaagcaugaccagguugaaacccccgugacagggggcggaggaccgaaccggugccugcugaaacagucucggaugaguuguguuuaggagugaaaagcuaaccgaaccuggagauagcuaguucuccccgaaauguauugagguacagccucggauguugaccauguccuguagagcacucacaaggcuaaaaccuuaugaaacuccgaaggggcacgcguuuaguccgggagugaggcugcgagagcuaacuuccguagccgagagggaaacaacccagaccaucagcuaaggucccuaaaugaucgcucagugguuaaggaugugucgucgcauagacagccaggagguuggcuuagaagcagccacccuucaaagagugcguaauagcucacuggucgagugacgaugcgccgaaaaugaucggggcucaagugaucuaccgaagcuauggauucaacucgcgaagcgaguugucugguaggggagcguucaguccgcggagaagccauaccggaaggagugguggagccgacugaagugcggaugccggcaugaguaacgauaaaagaagugagaaucuucuucgccguaaggacaaggguuccuggggaagggucguccgcccagggaaagucgggaccuaaggugaggccgaacggcgcagccgauggacagcaggucaagauuccugcaccgaucauguggagugauggagggacgcauuacgcuauccaaugccaagcuauggcuaugcugguugguacgcucaagggcgaucgggucagaaaaucuaccggucacaugccucagacguaucgggagcuuccucggaagcgaaguuggaaacgcgacggugccaagaaaagcuucuaaacguugaaacaugauugcccguaccgcaaaccgacacagguguccgagugucaaugcacuaaggcgcgcgagagaacccucguuaaggaacuuugcaaucucaccccguaacuucggaagaagggguccccacgcuucgcguggggcgcagugaauaggcccaggcgacuguuuaccaaaaucacagcacucugccaacacgaacaguggacguauagggugugacgccugcccggugccggaaggucaaguggagcggugcaagcugcgaaaugaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaggcguaacgaucugggcgcugucucaacgagggacucggugaaauugaauuggcuguaaagaugcggccuacccguagcaggacgaaaagaccccguggagcuuuacuauagucuggcauugggauucggguuucucugcguaggugggagaaacuggccggucgguggccacccugagaaacuuggauuucuaaccugaaaaaucacuuucggggaccgugcuuggcggguaguuugacuggggcggucgccucccaaaauguaacggaggcgcccaaaggucaccucaagacgguuggaaaucgucuguagagcgcaaagguagaagguggcuugacugcgagacugacacgucgagcagggaggaaacucgggcuuagugaaccggugguaccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagaguccauaucggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgcuacgggcgcaggagaauugaggggaguugcuccuaguacgagaggaccggagugaacggaccgcuggucucccugcugucguaccaacggcacaugcaggguagcuauguccggaacggauaaccgcugaaagcaucuaagcgggaagccagccccaagaugaguucucccacuguucagguaagacucccggaagaccaccggguuaagaggccaggcgugcacgcauagcaauguguucagcggacuggugcucaucagucgaggucuugacca 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((((((((......(.((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...((.]]..]]..))......))))))...)))....(((....)))(((((....)))))((((....))))))...((((((...................))))).).........(......)..((.((......((.....)).....)).)...(((.....((((((.(((..(((...(((((......)))))[[(...).(((.....]])))...)))....))).))))))......((((.((((.......)))).))))......(((((..[[[[)))))..)))...)..)).)))))).))..............((....))....)).........((((....)))).............).....)))))))).).......((((((((((.......)))))))))).[.(.(........).).((((((....(((.((((((((.(..((....(((....)))....))...((....))......................).)))))))))))..((.(...((((((.....(((((..((..((((....(((((......)))))....).)))...((...(.((........)).)..))....))..)))))...((.......))......))))))......).))..(((.((....(((((....))))).(((((((...(.(((.(((((....(((...(((..(((......)))..)))..)).)....))))).).))..).)))))).)...(((((((..(......)..)))))))....(((......)))...((((.(((...((([[[...(.(((..(.....(.....((..((.(((((.(.......(((((.(((..(((.........)))..))).....(...((......)).).)))).)..).))))).)).))..........]]].)....)..)))))))...)))))))...((((.((.....)).)))).......)).)))(.(((((((.((.......(((..((....))..)))....)).)))))))..).....))))))(......((.....((((((.......))))))((((....((.(..((...((((((...((.....)).))))))....[[((((.((...(.....(((....))).....)...))...(((((........)))))]](((((((((...((....(((....(((((.(((..(((((..(((.((...{.....)))))..(.((((.(.(..(..((.(((....(.....)..))).)).....).)...))))))......((((....)))).....)))))...)))..)))))(..).....)))....))......)))))))))))))..)).....(((...).)).).)).((((......))))..))))..((((....((((((((.(...(....(.........(((....(.[..).....)))..((((((((...))))))))(...).......((((((.((...(...........)...((((.((.....(((.....))).......)).)))).]((((.(((..((.(((...(..(...(...((.((....)).))...)....).).)))...)))))(.((((.......)))).)........((..........(((((.......)))))..)..)....))))...))..)))))).)..).).)))))))).)))))).....)..{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.((((..(((((.(..((.((((.(....(((((.....((.(((()))).))..)))))).)))).))..).)))))...((.((((......)))).)).....)))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...)..(][.[[[).....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....((.(.(..((..]]]]..)).).).)).....)}......))))..))))))......(.((..(.((((.(...((.......))...).))))...).))...)......((((.((.(((..((((((((........)))))..))).(((((.....))))).....))).)..)...))).).....(((((((....))).))))....)...)))))))))))[...(((((((...((((..(..((((.....(....)....))))..).(((((.....((...(((((((.(((..}.))).))...)))))...))...)))))....((....((((.............))))....))..))))..]....)))))))..(((..)))....(((((((((.......))))).....((.((((.(((.....((.(....).))....)))..))))..))....))))....)))))))). Inhibition of peptide bond formation by pleuromutilins: The structure of the 50S ribosomal subunit from Deinococcus radiodurans in complex with Tiamulin; 23S RIBOSOMAL RNA 1xbp 9 118 3.5 RF00001 URS0000420396_1299 15554968 0003735 0005840 1299 cccccgugcccauagcacuguggaaccaccccaccccaugccgaacugggucgugaaacacagcagcgccaaugauacucggaccgcagggucccggaaaagucggucagcgcggggg <<<<<<<<<.....<<.<<<<<....<<<<<<<.............>>>>..>>>...>>>>>..>><<<.......<<.<<<<<....>>>>>.>>.......>>>..>>>>>>>>> ((((((.((.....((.(((((...(.(((((...............)))..)))...)))))..))(((.......((.(((((....))))).)).......)))..)).)))))) Inhibition of peptide bond formation by pleuromutilins: The structure of the 50S ribosomal subunit from Deinococcus radiodurans in complex with Tiamulin; 5S RIBOSOMAL RNA 1xmo A 1507 3.25 RF00177,RF01959,RF01960 URS000080E226_262724 15558052 0003735 0005840 262724 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuaggaacccgggugaaagccuggggugccccggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagcaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucacuuucu ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<<.....>>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<.....>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>.....................................<<<<<........<<........>>...........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<<..>>>...>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<...<<<.....>>>.>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<..<.<<<<<<<........>>>>>>>>...>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<<..>>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.....)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.((.((....)).)).))))...((.......)).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).)))))).....................................(((((...(.....(........).......)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((.(((...(..(((....)))..).....(....)....))).)))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...(...((.......)).)....)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Crystal Structure of mnm5U34t6A37-tRNALysUUU Complexed with AAG-mRNA in the Decoding Center; 16S ribosomal RNA 1xmo X 11 3.25 URS000080DD95_32630 15558052 32630 gacunuunauc <<.......>> ((.......)) Crystal Structure of mnm5U34t6A37-tRNALysUUU Complexed with AAG-mRNA in the Decoding Center; Anticodon Transfer RNA 1xmq A 1507 3.0 RF00177,RF01959,RF01960 URS000080E226_300852 15558052 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuaggaacccgggugaaagccuggggugccccggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagcaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucacuuucu ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<<.....>>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<.<<....>>.>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<.......................>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<....<<..<<<....>>>..>>................>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<<..>>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.....)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.((.((....)).)).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((.......................))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((......(((((......(.(((....)))..)......(..).......)))))..((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((.........(.....)........)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Crystal Structure of t6A37-ASLLysUUU AAA-mRNA Bound to the Decoding Center; 16s ribosomal RNA 1xmq X 11 3.0 URS000080DD95_32630 15558052 32630 gacuuuunauc <<.......>> ((.......)) Crystal Structure of t6A37-ASLLysUUU AAA-mRNA Bound to the Decoding Center; Anticodon RNA 1xnq A 1507 3.05 RF00177,RF01959,RF01960 URS000080E226_274 15558050 0003735 0005840 274 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuaggaacccgggugaaagccuggggugccccggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagcaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucacuuucu ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<<.....>>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>.....................................<<<<<......<................>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<<..>>>...>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.....)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(..((....))..).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..............(......)...............(((((...(...............(..)...)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...((.(((....))).))....(.(..).)...)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(....(((.....)))..)...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Structure of an Inosine-Adenine Wobble Base Pair Complex in the Context of the Decoding Center; 16S ribosomal RNA 1xnq X 11 3.05 URS000080E223_32630 15558050 32630 ggcuicgaacc <<.......>> .(.......). Structure of an Inosine-Adenine Wobble Base Pair Complex in the Context of the Decoding Center; Anticodon tRNA 1xnr A 1507 3.1 RF00177,RF01959,RF01960 URS000080E226_274 15558050 0003735 0005840 274 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuaggaacccgggugaaagccuggggugccccggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagcaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucacuuucu ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<<.....>>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>.....................................<<<<<......<..<........>....>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<<..>>>...>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.....)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(..((....))..).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).)))))).....................................(((((...(......................)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((.....)))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((.((...((((((....))))))....(((..)))...)).))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...(...(((.....)))).....)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.....]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Crystal Structure of an Inosine-Cytosine Wobble Base Pair in the Context of the Decoding Center; 16S Ribosomal RNA 1xnr X 11 3.1 URS000080E223_32630 15558050 32630 ggcuicgaacc .<.......>. ((.......)) Crystal Structure of an Inosine-Cytosine Wobble Base Pair in the Context of the Decoding Center; Anticodon tRNA 1xok A 27 3.0 URS000080DFD9_32630 15604410 32630 augcucaugcacugcaugaaugccccu ....<<<<<.....>>>>>........ ...((((((.....)))))..)..... crystal structure of alfalfa mosaic virus RNA 3'UTR in complex with coat protein N terminal peptide; alfalfa mosaic virus RNA 3' UTR 1xp7 A 23 2.5 URS000080E167_32630 16403527 32630 cuugcugaagugcacacagcaag <<<<<<<.........>>>>>>> (((((((.........))))))) HIV-1 subtype F genomic RNA Dimerization Initiation Site; 5'-R(*CP*UP*UP*GP*CP*UP*GP*AP*AP*GP*UP*GP*CP*AP*CP*AP*CP*AP*GP*CP*AP*AP*G)-3' 1xp7 B 23 2.5 URS000080E167_32630 16403527 32630 cuugcugaagugcacacagcaag <<<<<<<.........>>>>>>> (((((((.........))))))) HIV-1 subtype F genomic RNA Dimerization Initiation Site; 5'-R(*CP*UP*UP*GP*CP*UP*GP*AP*AP*GP*UP*GP*CP*AP*CP*AP*CP*AP*GP*CP*AP*AP*G)-3' 1xpe A 23 1.94 URS000080DD3F_32630 16403527 32630 cuugcugaagcgcgcacggcaag <<<<<<<.........>>>>>>> (((((((.........))))))) HIV-1 subtype B genomic RNA Dimerization Initiation Site; 5'-R(*CP*UP*UP*GP*CP*UP*GP*AP*AP*GP*CP*GP*CP*GP*CP*AP*CP*GP*GP*CP*AP*AP*G)-3' 1xpe B 23 1.94 URS000080DD3F_32630 16403527 32630 cuugcugaagcgcgcacggcaag <<<<<<<.........>>>>>>> (((((((.........))))))) HIV-1 subtype B genomic RNA Dimerization Initiation Site; 5'-R(*CP*UP*UP*GP*CP*UP*GP*AP*AP*GP*CP*GP*CP*GP*CP*AP*CP*GP*GP*CP*AP*AP*G)-3' 1xpf A 23 2.3 URS000080E21C_32630 16403527 32630 cuugcugaggugcacacagcaag <<<<<<<.........>>>>>>> (((((((.........))))))) HIV-1 subtype A genomic RNA Dimerization Initiation Site; 5'-R(*CP*UP*UP*GP*CP*UP*GP*AP*GP*GP*UP*GP*CP*AP*CP*AP*CP*AP*GP*CP*AP*AP*G)-3' 1xpf B 23 2.3 URS000080E21C_32630 16403527 32630 cuugcugaggugcacacagcaag <<<<<<<.........>>>>>>> (((((((.........))))))) HIV-1 subtype A genomic RNA Dimerization Initiation Site; 5'-R(*CP*UP*UP*GP*CP*UP*GP*AP*GP*GP*UP*GP*CP*AP*CP*AP*CP*AP*GP*CP*AP*AP*G)-3' 1xv0 A 10 NA URS000080DE92_32630 15723528 32630 gguggaggcu .......... .......... Solution NMR structure of RNA internal loop with three consecutive sheared GA pairs in 5'GGUGGAGGCU/3'PCCGAAGCCG; 5'-R(*GP*GP*UP*GP*GP*AP*GP*GP*CP*U)-3' 1xv0 B 10 NA URS000080E10B_32630 15723528 32630 gccgaagccn .......... .......... Solution NMR structure of RNA internal loop with three consecutive sheared GA pairs in 5'GGUGGAGGCU/3'PCCGAAGCCG; 5'-R(*GP*CP*CP*GP*AP*AP*GP*CP*CP*(P5P)-3' 1y0q A 229 3.6 RF00028 URS000080E2FF_55510 15580277 0000372 55510 gagccuuuauacaguaauguauaucgaaaaauccucuaauucagggaacaccuaaggcaauccugagcuaagcucuuaguaauaagagaaagugcaacgacuauuccgauaggaaguagggucaagugacucgaaauggggauuacccuucuaggguagugauauagucugaacauauauggaaacauauagaaggauaggaguaacgaaccuauccguaacauaauug .......<<<<<<....>>>>>>.......<<<<<<....<<<<<<....<<<.>>>...>>>>>><<<...<<<<<<....>>>>>>..>>>.....((((.<<<<....>>>>...<<<<<..[[>>>>>.....>>>>>><<<<<<...>>>>>>.......))))..<<..<<<<<<....>>>>>>...<<<<<<<....]]...>>>>>>>.........>>. ....(..((((((....))))))..)....((((((....((((((....(((.)))...))))))(((...((((((....))))))..)))...[.[[[[[((((....))))...(((((..{{))))).....))))))(((((.....)))))......]]]]]].((..((((((....))))))...(((((((....}}...))))))).........)). Crystal structure of an active group I ribozyme-product complex; Group I ribozyme 1y3o A 23 2.7 URS000080E167_32630 16403527 32630 cungcugaagugcacacagcaag <<<<<<<.........>>>>>>> (((((((.........))))))) HIV-1 DIS RNA subtype F- Mn soaked; 5'-R(*CP*UP*(5BU)P*GP*CP*UP*GP*AP*AP*GP*UP*GP*CP*AP*CP*AP*CP*AP*GP*CP*AP*AP*G)-3' 1y3o B 23 2.7 URS000080E167_32630 16403527 32630 cungcugaagugcacacagcaag <<<<<<<.........>>>>>>> (((((((.........))))))) HIV-1 DIS RNA subtype F- Mn soaked; 5'-R(*CP*UP*(5BU)P*GP*CP*UP*GP*AP*AP*GP*UP*GP*CP*AP*CP*AP*CP*AP*GP*CP*AP*AP*G)-3' 1y3s A 23 2.25 URS000080E167_32630 16403527 32630 cungcugaagugcacacagcaag <<<<<<<.........>>>>>>> (((((((.........))))))) HIV-1 DIS RNA subtype F- MPD form; 5'-R(*CP*UP*(5BU)P*GP*CP*UP*GP*AP*AP*GP*UP*GP*CP*AP*CP*AP*CP*AP*GP*CP*AP*AP*G)-3' 1y3s B 23 2.25 URS000080E167_32630 16403527 32630 cungcugaagugcacacagcaag <<<<<<<.........>>>>>>> (((((((.........))))))) HIV-1 DIS RNA subtype F- MPD form; 5'-R(*CP*UP*(5BU)P*GP*CP*UP*GP*AP*AP*GP*UP*GP*CP*AP*CP*AP*CP*AP*GP*CP*AP*AP*G)-3' 1y69 0 2766 3.33 RF02540,RF02541 URS000080DEF1_243230 15616575 0003735 0005840 243230 ggucaagauaguaaggguccacgguggaugcccuggcgcuggagccgaugaaggacgcgauuaccugcgaaaagccccgacgagcuggagauacgcuuugacucggggauguccgaauggggaaacccaccucguaagagguauccgcaaggaugggaacucagggaacugaaacaucucaguaccugaaggagaagaaagagaauucgauuccguuaguagcggcgagcgaacccggaucagcccaaauucaaccccucaagccgaaguggcuggaaagcuacaccucagaaggugagaguccuguaggcgaacgagcgguugacuguaaggucguuguucgugaaacgaugacugaauccgcgcggaccaccgcgcaaggcuaaauacucccagugaccgauagcgcauaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaagagaaccugaaaccguggacuuacaagcagucauggcaccuuaugcguguuauggcgugccuauugaagcaugagccggcgacuuagaccugacgugcgagcuuaaguugaaaaacggaggcggagcgaaagcgaguccgaauagggcggcauuaguacgucgggcuagacucgaaaccaggugagcuaagcaugaccagguugaaacccccgugacagggggcggaggaccgaaccggugccugcugaaacagucucggaugaguuguguuuaggagugaaaagcuaaccgaaccuggagauagcuaguucuccccgaaauguauugagguacagccucggauguugaccauguccuguagagcacucacaaggcuaaaaccuuaugaaacuccgaaggggcacgcguuuaguccgggagugaggcugcgagagcuaacuuccguagccgagagggaaacaacccagaccaucagcuaaggucccuaaaugaucgcucagugguuaaggaugugucgucgcauagacagccaggagguuggcuuagaagcagccacccuucaaagagugcguaauagcucacuggucgagugacgaugcgccgaaaaugaucggggcucaagugaucuaccgaagcuauggauucaacucgcgaagcgaguugucugguaggggagcguucaguccgcggagaagccauaccggaaggagugguggagccgacugaagugcggaugccggcaugaguaacgauaaaagaagugagaaucuucuucgccguaaggacaaggguuccuggggaagggucguccgcccagggaaagucgggaccuaaggugaggccgaacggcgcagccgauggacagcaggucaagauuccugcaccgaucauguggagugauggagggacgcauuacgcuauccaaugccaagcuauggcuaugcugguugguacgcucaagggcgaucgggucagaaaaucuaccggucacaugccucagacguaucgggagcuuccucggaagcgaaguuggaaacgcgacggugccaagaaaagcuucuaaacguugaaacaugauugcccguaccgcaaaccgacacagguguccgagugucaaugcacuaaggcgcgcgagagaacccucguuaaggaacuuugcaaucucaccccguaacuucggaagaagggguccccacgcuucgcguggggcgcagugaauaggcccaggcgacuguuuaccaaaaucacagcacucugccaacacgaacaguggacguauagggugugacgccugcccggugccggaaggucaaguggagcggugcaagcugcgaaaugaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaggcguaacgaucugggcgcugucucaacgagggacucggugaaauugaauuggcuguaaagaugcggccuacccguagcaggacgaaaagaccccguggagcuuuacuauagucuggcauugggauucggguuucucugcguaggugggagaaacuggccggucgguggccacccugagaaacuuggauuucuaaccugaaaaaucacuuucggggaccgugcuuggcggguaguuugacuggggcggucgccucccaaaauguaacggaggcgcccaaaggucaccucaagacgguuggaaaucgucuguagagcgcaaagguagaagguggcuugacugcgagacugacacgucgagcagggaggaaacucgggcuuagugaaccggugguaccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagaguccauaucggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgcuacgggcgcaggagaauugaggggaguugcuccuaguacgagaggaccggagugaacggaccgcuggucucccugcugucguaccaacggcacaugcaggguagcuauguccggaacggauaaccgcugaaagcaucuaagcgggaagccagccccaagaugaguucucccacuguucagguaagacucccggaagaccaccggguuaagaggccaggcgugcacgcauagcaauguguucagcggacuggugcucaucagucgaggucuugacca <<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<<((..((>>>>.....<<<<<<...<<.))..))..>>......>>>>>>...>>>....<<<....>>><<<<<....>>>>>.<<<....>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<......<<.....>>.....>>>>...<<<...<.<<<<<<..<<..<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>....>>..>>>>>>.>....<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>..............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<.......>>>>>>>>>>...<.<........>.>.<<<<<<...<<<<.<<<<<<<<<....<.................>.....<<....>>...<<......>>..........>>>>>>>>>>>>>.<<.<...<<<<<<.....<<<<<<<<<..<<<.....<<<<<......>>>>>......>>>...<<<..<.<<........>>.>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<...<<<<.<<<<<<...<<<...<<<.<<<<......>>>>.>>>..>>.>...>>>>>>.>.>>>..>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<...<<<.......>>>...>>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>>..<.<<<<<<.....>>>>>>>.......>>>>>>..<<<<<<<.<<......<<<<<.<<....>>.>>>>>...>>.>>>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<...<<...<.......<<<<..<<<..<<<<<.<<<<.<<...[[....>>>>>>.<.........<<<..<<<<<<.............>>>>>>.....>>>........>.....<<<<<<..>>>>>>....>>>>>...>>>...>>>>............>...>>......>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<<..............<<<<<....<....>.....>>>>><<<<<<<<...>>>>>>>>............<<<<<<<<<..<<...........>>..<<<<<<<.....<<<.....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>....>>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<..<<<<<<.<<<<.<<<<.<....<<<<<.....<<<<<<..>>>>>>..>>>>>>.>>>>.>>>>.>>>>>>...<<<<<<........>>>>>>.....>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<.<<<..<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>......>>>..>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.]].>>>>>>...>>>>>...>>>>.>>>>>....<<....<<<<<...........>>>>>....>>..>>>>.......>>>>>>>..<<....>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>>>. ((((((((......((((((((((.....(((..(((.((((((((......((((((.[[..[[[)))..]..((((((...((.]]..]]..))......))))))...)))....(((....)))(((((....))))).(((....))).))...((((((.....((....))......))))).).........((....))..(((((......((.....)).....))))...(((.....((((((..((..(((...((.((......)).))[[(...).(((.....]])))...)))....))..)))))).......((((((((.[.....)))))))).......(((((].[[[[)))))..)))...)..)).)))).).))..............((....))....)).........((((....)))).............).....)))))))))).......((((((((((.......)))))))))).[.(.(........).).((((((....(((.((((((((((...........................((....))...((......)).........)))))))))))))..((.(...((((((...(.(((((((((..((((....(((((......)))))....)[)))...(((..(.((........)).).)))....))))))))).).(((.....)))......))))))......).))..((((((....(((((....)))))(((((((((....(((.(((((....(((...(((.((((......)))).)))..)).)....))))).).))...))))))).))..(((((((.((......)).)))))))....(((......)))...(((..(((...((([[[...(.((((((.....(.....((..((((((((.(.......(((((.(((..(((.........)))..))).....(...((......)).).)))).)..).)))))))).))..........]]].)....))))))))))...))).)))....(((.(((...))).)))........))))))(.(((((((.((......(((((.((....)).)))))...)).)))))))..).....))))))(......((.....((((((.......))))))((((....((((..((...((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((...((....(((....((((..(((..(((((..(((.((...{{....)))))....(((......((..((.(((....(.....)..))).)).....))......)))......(((((....)))))....)))))...)))...))))(..).....)))....))......)))))))))))))..)).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(........((((....(....).....)))).((((((((...))))))))(...).......(((((((((.].(...........)...(((((((.....(((.....))).......)))))))..((((.(((..(((((((..(((...((...((.((....)).))...))...))))))))..)))))..((.(.......).))..........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)..{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((..(((..(.(((.(..((.((((.(....(((((.....((((.(()).))))..)))))).)))).))..).))).)...(((((((......))))))).....)))..)))..)))))..(((......[)))((((((..(....)..]))))))([((...(((((((.(.(((((.........)))))...)..(][.[[[).....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....((.(((..((..]]]]..)).))).)).....)}......))))..))))))......(((((...((((((...((.......))...))))))....))).).).....(((((.((.(((..(((((((((......))))))..))).(((((.....))))).....))).)..)...))).))....(((((((....))).))))....)...)))))))))))[...(((((((...((((..(((((((...............))))))).(((((...(((....(((((((.(((.}}.))).))...)))))....))).)))))....((....((((.............))))....))..))))..]....)))))))..(.(..).)....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))....)))))))). RRF domain I in complex with the 50S ribosomal subunit from Deinococcus radiodurans; 23S ribosomal RNA 1y69 9 118 3.33 RF00001 URS0000420396_243230 15616575 0003735 0005840 243230 cccccgugcccauagcacuguggaaccaccccaccccaugccgaacugggucgugaaacacagcagcgccaaugauacucggaccgcagggucccggaaaagucggucagcgcggggg <<<<<<<<<.....<<.<<<<<....<<<<<<<.............>>>>..>>>...>>>>>..>><<<.......<<.<<<<<....>>>>>.>>.......>>>..>>>>>>>>> (((((((((.....((.(((((....((((((...............)))..)))...)))))..))(((.......((.(((((....))))).)).......)))..))))))))) RRF domain I in complex with the 50S ribosomal subunit from Deinococcus radiodurans; 5S ribosomal RNA 1y6s A 23 2.9 URS000080E21C_32630 12736317 32630 cuugcugaggugcacacagcaag ....................... ....................... HIV-1 DIS(Mal) duplex Ba-soaked; 5'-R(*CP*UP*UP*GP*CP*UP*GP*AP*GP*GP*UP*GP*CP*AP*CP*AP*CP*AP*GP*CP*AP*AP*G)-3' 1y6s B 23 2.9 URS000080E21C_32630 12736317 32630 cuugcugaggugcacacagcaag ....................... ....................... HIV-1 DIS(Mal) duplex Ba-soaked; 5'-R(*CP*UP*UP*GP*CP*UP*GP*AP*GP*GP*UP*GP*CP*AP*CP*AP*CP*AP*GP*CP*AP*AP*G)-3' 1y6t A 23 2.6 URS000080E21C_32630 12736317 32630 cuugcugaggugcacacagcaag ....................... ....................... HIV-1 Dis(Mal) Duplex Co Hexamine-Soaked; 5'-R(*CP*UP*UP*GP*CP*UP*GP*AP*GP*GP*UP*GP*CP*AP*CP*AP*CP*AP*GP*CP*AP*AP*G)-3' 1y6t B 23 2.6 URS000080E21C_32630 12736317 32630 cuugcugaggugcacacagcaag ....................... ....................... HIV-1 Dis(Mal) Duplex Co Hexamine-Soaked; 5'-R(*CP*UP*UP*GP*CP*UP*GP*AP*GP*GP*UP*GP*CP*AP*CP*AP*CP*AP*GP*CP*AP*AP*G)-3' 1y73 A 23 2.9 URS000080E21C_32630 12736317 32630 cuugcugaggugcacacagcaag ....................... ....................... HIV-1 Dis(Mal) Duplex Pt-Soaked; 5'-R(*CP*UP*UP*GP*CP*UP*GP*AP*GP*GP*UP*GP*CP*AP*CP*AP*CP*AP*GP*CP*AP*AP*G)-3' 1y73 B 23 2.9 URS000080E21C_32630 12736317 32630 cuugcugaggugcacacagcaag ....................... ....................... HIV-1 Dis(Mal) Duplex Pt-Soaked; 5'-R(*CP*UP*UP*GP*CP*UP*GP*AP*GP*GP*UP*GP*CP*AP*CP*AP*CP*AP*GP*CP*AP*AP*G)-3' 1y90 A 23 3.08 URS000080E21C_32630 12736317,10574792 32630 cnugcugaggugcacacagcaag ....................... ....................... HIV-1 Dis(Mal) Duplex Mn-Soaked; 5'-R(*CP*(5BU)P*UP*GP*CP*UP*GP*AP*GP*GP*UP*GP*CP*AP*CP*AP*CP*AP*GP*CP*AP*AP*G)-3' 1y90 B 23 3.08 URS000080E21C_32630 12736317,10574792 32630 cnugcugaggugcacacagcaag ....................... ....................... HIV-1 Dis(Mal) Duplex Mn-Soaked; 5'-R(*CP*(5BU)P*UP*GP*CP*UP*GP*AP*GP*GP*UP*GP*CP*AP*CP*AP*CP*AP*GP*CP*AP*AP*G)-3' 1y95 A 23 2.8 URS000080E21C_32630 12736317 32630 cuugcugaggugcacacagcaag ....................... ....................... HIV-1 Dis(Mal) Duplex Pb-Soaked; 5'-R(*CP*UP*UP*GP*CP*UP*GP*AP*GP*GP*UP*GP*CP*AP*CP*AP*CP*AP*GP*CP*AP*AP*G)-3' 1y95 B 23 2.8 URS000080E21C_32630 12736317 32630 cuugcugaggugcacacagcaag ....................... ....................... HIV-1 Dis(Mal) Duplex Pb-Soaked; 5'-R(*CP*UP*UP*GP*CP*UP*GP*AP*GP*GP*UP*GP*CP*AP*CP*AP*CP*AP*GP*CP*AP*AP*G)-3' 1y99 A 23 2.4 URS000080E21C_32630 10574792 32630 cuugcugaggugcacacagcaag ....................... ....................... HIV-1 subtype A DIS RNA duplex; 5'-R(*CP*UP*UP*GP*CP*UP*GP*AP*GP*GP*UP*GP*CP*AP*CP*AP*CP*AP*GP*CP*AP*AP*G)-3' 1y99 B 23 2.4 URS000080E21C_32630 10574792 32630 cuugcugaggugcacacagcaag ....................... ....................... HIV-1 subtype A DIS RNA duplex; 5'-R(*CP*UP*UP*GP*CP*UP*GP*AP*GP*GP*UP*GP*CP*AP*CP*AP*CP*AP*GP*CP*AP*AP*G)-3' 1yhq 0 2754 2.4 RF02540,RF00002 URS000080E07C_2238 15851032 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagcuguggggagccgcacggaggcgaagaaccacagauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaacgugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucuucacgaagucucuuggaauagagcgugauacagggugacaaccccguacugaagaccaguacgcugugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccuugacgaaugaccgagacgcgagucuccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucuguauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgcuguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaagcaggggcgagagcuccuguggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucucaccgcaacucgacugagacgaaaugggaaacagguuaauauuccugugccaucaugcagugaaaguugacgcccuggggucgaucacgccgggcaucgcccggucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcaugauguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcaaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggucaucucagccggggacccggcgaagagugcaagagcaaaagaugacuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcugggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>...<<<<<.....<<.....>>....>>>>>...<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<<<<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>>>>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<.<<<.........<<<<<....>>>>>.........>>>.>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<...<<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>>.<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<.<<<.....>>>.>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<<...<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>.>>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......((((.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......))))...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((.(((....(....(((((....))))).....)...))).))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.(((....(((((((....)))))))....[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Crystal Structure Of Azithromycin Bound To The G2099A Mutant 50S Ribosomal Subunit Of Haloarcula Marismortui; 23S Ribosomal RNA 1yhq 9 122 2.4 RF00001 URS00000A7E81_2238 15851032 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccagggaguacuggagugcgcgagccucugggaaauccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<.<<.....<<<<<<.<<....>>>>>>>>....>>.>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...((.((.....((((((.((....))))))))....)).))...))))))... Crystal Structure Of Azithromycin Bound To The G2099A Mutant 50S Ribosomal Subunit Of Haloarcula Marismortui; 5S Ribosomal RNA 1yi2 0 2754 2.65 RF02540,RF00002 URS000080E07C_2238 15851032 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagcuguggggagccgcacggaggcgaagaaccacagauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaacgugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucuucacgaagucucuuggaauagagcgugauacagggugacaaccccguacugaagaccaguacgcugugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccuugacgaaugaccgagacgcgagucuccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucuguauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgcuguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaagcaggggcgagagcuccuguggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucucaccgcaacucgacugagacgaaaugggaaacagguuaauauuccugugccaucaugcagugaaaguugacgcccuggggucgaucacgccgggcaucgcccggucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcaugauguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcaaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggucaucucagccggggacccggcgaagagugcaagagcaaaagaugacuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcugggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>...<<<<<.....<<.....>>....>>>>>...<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<<<<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>>>>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<.<<<.........<<<<<....>>>>>.........>>>.>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<.<<<.....>>>.>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<....<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>..>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......((((.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......))))...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((.(((....(....(((((....))))).....)...))).))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Crystal Structure Of Erythromycin Bound To The G2099A Mutant 50S Ribosomal Subunit Of Haloarcula Marismortui; 23S Ribosomal RNA 1yi2 9 122 2.65 RF00001 URS00000A7E81_2238 15851032 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccagggaguacuggagugcgcgagccucugggaaauccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<.<<.....<<<<<<.<<....>>>>>>>>....>>.>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...((.(......((((((.((....)))))))).....).))...))))))... Crystal Structure Of Erythromycin Bound To The G2099A Mutant 50S Ribosomal Subunit Of Haloarcula Marismortui; 5S Ribosomal RNA 1yij 0 2754 2.6 RF02540,RF00002 URS000080E07C_2238 15851032 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagcuguggggagccgcacggaggcgaagaaccacagauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaacgugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucuucacgaagucucuuggaauagagcgugauacagggugacaaccccguacugaagaccaguacgcugugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccuugacgaaugaccgagacgcgagucuccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucuguauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgcuguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaagcaggggcgagagcuccuguggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucucaccgcaacucgacugagacgaaaugggaaacagguuaauauuccugugccaucaugcagugaaaguugacgcccuggggucgaucacgccgggcaucgcccggucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcaugauguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcaaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggucaucucagccggggacccggcgaagagugcaagagcaaaagaugacuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcugggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>...<<<<<.....<<.....>>....>>>>>...<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<<<<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>>>>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<.<<<.........<<<<<....>>>>>.........>>>.>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<...<<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>>.<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<.<<<.....>>>.>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<....<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>..>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......((((.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......))))...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......(...(((.....))).............)).....)))))))))......(.((((((((((....((((((.(((....(....(((((....))))).....)...))).))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Crystal Structure Of Telithromycin Bound To The G2099A Mutant 50S Ribosomal Subunit Of Haloarcula Marismortui; 23S Ribosomal RNA 1yij 9 122 2.6 RF00001 URS00000A7E81_2238 15851032 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccagggaguacuggagugcgcgagccucugggaaauccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<.<<.....<<<<<<.<<....>>>>>>>>....>>.>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...((.(......((((((.((....)))))))).....).))...))))))... Crystal Structure Of Telithromycin Bound To The G2099A Mutant 50S Ribosomal Subunit Of Haloarcula Marismortui; 5S Ribosomal RNA 1yit 0 2754 2.8 RF02540,RF00002 URS000080DF5B_2238 15851032 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagcuguggggagccgcacggaggcgaagaaccacagauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaacgugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucuucacgaagucucuuggaauagagcgugauacagggugacaaccccguacugaagaccaguacgcugugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccuugacgaaugaccgagacgcgagucuccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucuguauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgcuguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaagcaggggcgagagcuccuguggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucucaccgcaacucgacugagacgaaaugggaaacagguuaauauuccugugccaucaugcagugaaaguugacgcccuggggucgaucacgccgggcaucgcccggucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcaugauguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcgaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggucaucucagccggggacccggcgaagagugcaagagcaaaagaugacuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcugggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>...<<<<<.....<<.....>>....>>>>>...<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<<<<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>>>>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<.<<<.........<<<<<....>>>>>.........>>>.>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<<<<<.....>>>>>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<<...<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>.>>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......((((.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......))))...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((.(((....(....(((((....))))).....)...))).))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Crystal Structure Of Virginiamycin M and S Bound To The 50S Ribosomal Subunit Of Haloarcula Marismortui; 23S RIBOSOMAL RNA 1yit 9 122 2.8 RF00001 URS00000A7E81_2238 15851032 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccagggaguacuggagugcgcgagccucugggaaauccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<.<<.....<<<<<<.<<....>>>>>>>>....>>.>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...((.(......((((((.((....)))))))).....).))...))))))... Crystal Structure Of Virginiamycin M and S Bound To The 50S Ribosomal Subunit Of Haloarcula Marismortui; 5S RIBOSOMAL RNA 1yj9 0 2754 2.8 RF02540,RF00002 URS000080DF5B_2238 15851032 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagcuguggggagccgcacggaggcgaagaaccacagauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaacgugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucuucacgaagucucuuggaauagagcgugauacagggugacaaccccguacugaagaccaguacgcugugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccuugacgaaugaccgagacgcgagucuccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucuguauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgcuguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaagcaggggcgagagcuccuguggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucucaccgcaacucgacugagacgaaaugggaaacagguuaauauuccugugccaucaugcagugaaaguugacgcccuggggucgaucacgccgggcaucgcccggucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcaugauguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcgaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggucaucucagccggggacccggcgaagagugcaagagcaaaagaugacuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcugggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<.....>>..<<<<<<.....<<.....>>....>>>>>>..<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<<<<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>>>>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<.<<<.........<<<<<....>>>>>.........>>>.>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<<<<<.....>>>>>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<....<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>..>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>..>>>..<<<<.....>>>>......>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......((((.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......))))...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((.(((....(....(((((....))))).....)...))).))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Crystal Structure Of The Mutant 50S Ribosomal Subunit Of Haloarcula Marismortui Containing a three residue deletion in L22; 23S Ribosomal RNA 1yj9 9 122 2.8 RF00001 URS00000A7E81_2238 15851032 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccagggaguacuggagugcgcgagccucugggaaauccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<.<<.....<<<<<<.<<....>>>>>>>>....>>.>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...((.(......((((((.((....)))))))).....).))...))))))... Crystal Structure Of The Mutant 50S Ribosomal Subunit Of Haloarcula Marismortui Containing a three residue deletion in L22; 5S Ribosomal RNA 1yjn 0 2754 3.0 RF02540,RF00002 URS000080E07C_2238 15851032 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagcuguggggagccgcacggaggcgaagaaccacagauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaacgugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucuucacgaagucucuuggaauagagcgugauacagggugacaaccccguacugaagaccaguacgcugugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccuugacgaaugaccgagacgcgagucuccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucuguauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgcuguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaagcaggggcgagagcuccuguggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucucaccgcaacucgacugagacgaaaugggaaacagguuaauauuccugugccaucaugcagugaaaguugacgcccuggggucgaucacgccgggcaucgcccggucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcaugauguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcaaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggucaucucagccggggacccggcgaagagugcaagagcaaaagaugacuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcugggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<.....>>...<<<<<.....<<.....>>....>>>>>...<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<<<<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>>>>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<.<<<.........<<<<<....>>>>>.........>>>.>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<<<<<.....>>>>>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<....<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>..>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......((((.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......))))...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......(...(((.....))).............)).....)))))))))......(.((((((((((....((((((.(((....(....(((((....))))).....)...))).))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)......))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Crystal Structure Of Clindamycin Bound To The G2099A Mutant 50S Ribosomal Subunit Of Haloarcula Marismortui; 23S Ribosomal RNA 1yjn 9 122 3.0 RF00001 URS00000A7E81_2238 15851032 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccagggaguacuggagugcgcgagccucugggaaauccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<.<<.....<<<<<<.<<....>>>>>>>>....>>.>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...((.(......((((((.((....)))))))).....).))...))))))... Crystal Structure Of Clindamycin Bound To The G2099A Mutant 50S Ribosomal Subunit Of Haloarcula Marismortui; 5S Ribosomal RNA 1yjw 0 2754 2.9 RF02540,RF00002 URS000080E07C_2238 15851032 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagcuguggggagccgcacggaggcgaagaaccacagauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaacgugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucuucacgaagucucuuggaauagagcgugauacagggugacaaccccguacugaagaccaguacgcugugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccuugacgaaugaccgagacgcgagucuccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucuguauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgcuguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaagcaggggcgagagcuccuguggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucucaccgcaacucgacugagacgaaaugggaaacagguuaauauuccugugccaucaugcagugaaaguugacgcccuggggucgaucacgccgggcaucgcccggucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcaugauguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcaaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggucaucucagccggggacccggcgaagagugcaagagcaaaagaugacuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcugggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>..<<<<<<.....<<.....>>....>>>>>>..<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<<<<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>>>>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<.<<<.........<<<<<....>>>>>.........>>>.>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<...<<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>>.<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<<<<<.....>>>>>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<....<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>..>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......((((.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......))))...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((.(((....(....(((((....))))).....)...))).))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Crystal Structure Of Quinupristin Bound To The G2099A Mutant 50S Ribosomal Subunit Of Haloarcula Marismortui; 23S RIBOSOMAL RNA 1yjw 9 122 2.9 RF00001 URS00000A7E81_2238 15851032 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccagggaguacuggagugcgcgagccucugggaaauccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<.<<.....<<<<<<.<<....>>>>>>>>....>>.>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...((.(......((((((.((....)))))))).....).))...))))))... Crystal Structure Of Quinupristin Bound To The G2099A Mutant 50S Ribosomal Subunit Of Haloarcula Marismortui; 5S RIBOSOMAL RNA 1ykq A 11 3.5 URS000080DF4A_32630 15723077 32630 ggagcucgccc ........... ........... Crystal structure of Diels-Alder ribozyme; Diels-Alder ribozyme 1ykq B 38 3.5 URS000080DEAC_32630 15723077 32630 gggcgaggccgugccagcucuucggagcaauacucggc .......<<<<.....<<<<....>>>>......>>>> .......((((.....((((....))))......)))) Crystal structure of Diels-Alder ribozyme; Diels-Alder ribozyme 1ykq C 11 3.5 URS000080DF4A_32630 15723077 32630 ggagcucgccc ........... ........... Crystal structure of Diels-Alder ribozyme; Diels-Alder ribozyme 1ykq D 38 3.5 URS000080DEAC_32630 15723077 32630 gggcgaggccgugccagcucuucggagcaauacucggc .......<<<<.....<<<<....>>>>......>>>> .......((((.....((((....))))......)))) Crystal structure of Diels-Alder ribozyme; Diels-Alder ribozyme 1ykv A 11 3.3 URS000080DF4A_32630 15723077 32630 ggagcucgccc ........... ........... Crystal structure of the Diels-Alder ribozyme complexed with the product of the reaction between N-pentylmaleimide and covalently attached 9-hydroxymethylanthracene; Diels-Alder ribozyme 1ykv B 38 3.3 URS000080DEAC_32630 15723077 32630 gggcgaggccgugccagcucuucggagcaauacucggc .......<<<<.....<<<<<..>>>>>......>>>> .......((((.....((((....))))......)))) Crystal structure of the Diels-Alder ribozyme complexed with the product of the reaction between N-pentylmaleimide and covalently attached 9-hydroxymethylanthracene; Diels-Alder ribozyme 1ykv C 11 3.3 URS000080DF4A_32630 15723077 32630 ggagcucgccc ........... ........... Crystal structure of the Diels-Alder ribozyme complexed with the product of the reaction between N-pentylmaleimide and covalently attached 9-hydroxymethylanthracene; Diels-Alder ribozyme 1ykv D 38 3.3 URS000080DEAC_32630 15723077 32630 gggcgaggccgugccagcucuucggagcaauacucggc .......<<<<.....<<<<<..>>>>>......>>>> .......((((.....((((....))))......)))) Crystal structure of the Diels-Alder ribozyme complexed with the product of the reaction between N-pentylmaleimide and covalently attached 9-hydroxymethylanthracene; Diels-Alder ribozyme 1yls A 11 3.0 URS000080DF4A_32630 15723077 32630 ggagcncgcnc ........... .......... Crystal structure of selenium-modified Diels-Alder ribozyme complexed with the product of the reaction between N-pentylmaleimide and covalently attached 9-hydroxymethylanthracene; RNA Diels-Alder ribozyme 1yls B 38 3.0 URS000080E1B2_32630 15723077 32630 gggngaggncgugccggcncuncggagcaauacucggc .......<<<<.....<<<<....>>>>......>>>> .......((((.....(((...).))......)))) Crystal structure of selenium-modified Diels-Alder ribozyme complexed with the product of the reaction between N-pentylmaleimide and covalently attached 9-hydroxymethylanthracene; RNA Diels-Alder ribozyme 1yls C 11 3.0 URS000080DF4A_32630 15723077 32630 ggagcncgcnc ........... .......... Crystal structure of selenium-modified Diels-Alder ribozyme complexed with the product of the reaction between N-pentylmaleimide and covalently attached 9-hydroxymethylanthracene; RNA Diels-Alder ribozyme 1yls D 38 3.0 URS000080E1B2_32630 15723077 32630 gggngaggncgugccggcncuncggagcaauacucggc .......<<<<.....<<<<....>>>>......>>>> .......((((.....(((...).))......)))) Crystal structure of selenium-modified Diels-Alder ribozyme complexed with the product of the reaction between N-pentylmaleimide and covalently attached 9-hydroxymethylanthracene; RNA Diels-Alder ribozyme 1yrj A 23 2.7 URS000080E29E_32630 15849690 32630 uugcgucacaccggugaagucgc ....................... ....................... Crystal Structure of Apramycin bound to a Ribosomal RNA A site oligonucleotide; Bacterial 16 S Ribosomal RNA A Site Oligonucleotide 1yrj B 22 2.7 URS000080E29E_32630 15849690 32630 ugcgucacaccggugaagucgc ...................... ...................... Crystal Structure of Apramycin bound to a Ribosomal RNA A site oligonucleotide; Bacterial 16 S Ribosomal RNA A Site Oligonucleotide 1yrm A 16 2.5 URS000080DF42_32630 16190727 32630 gcaganuuaaaucugc ................ ................ Crystal Structure of an RNA duplex containing site specific 2'-amine substitutions at a C-A mismatch; DNA/RNA (5'-R(*GP*CP*AP*GP*A)-D(P*(A5M))-R(P*UP*UP*AP*AP*AP*UP*CP*UP*GP*C)-3') 1yrm B 16 2.5 URS000080DF42_32630 16190727 32630 gcaganuuaaaucugc ................ ................ Crystal Structure of an RNA duplex containing site specific 2'-amine substitutions at a C-A mismatch; DNA/RNA (5'-R(*GP*CP*AP*GP*A)-D(P*(A5M))-R(P*UP*UP*AP*AP*AP*UP*CP*UP*GP*C)-3') 1yrm C 16 2.5 URS000080DF42_32630 16190727 32630 gcaganuuaaaucugc ................ ................ Crystal Structure of an RNA duplex containing site specific 2'-amine substitutions at a C-A mismatch; DNA/RNA (5'-R(*GP*CP*AP*GP*A)-D(P*(A5M))-R(P*UP*UP*AP*AP*AP*UP*CP*UP*GP*C)-3') 1ysh A 28 9.5 URS000080E2C0_32630 15864315 32630 gaugaagcgugccgaaaggcacguggaa ......<<<<<<<....>>>>>>>.... ..(...(((((((....)))))))...) Localization and dynamic behavior of ribosomal protein L30e; RNA (28-MER) 1ysh F 34 9.5 URS000080E2B3_32630 15864315 32630 caacuccguggaagccguaauggcaggaagcgga ....<<<<<....<<<<...>>>>.....>>>>> ....(((((....(((.....))).....))))) Localization and dynamic behavior of ribosomal protein L30e; RNA (34-MER) 1yvp C 10 2.2 URS000080DF3E_32630 15907467 32630 gcugguccga .......... .......... Ro autoantigen complexed with RNAs; Y RNA sequence, first strand 1yvp D 10 2.2 URS000080E06D_32630 15907467 32630 uugacuagcc .......... .......... Ro autoantigen complexed with RNAs; Y RNA sequence, second strand 1yvp E 10 2.2 URS000080DF3E_32630 15907467 32630 gcugguccga .......... .......... Ro autoantigen complexed with RNAs; Y RNA sequence, first strand 1yvp F 10 2.2 URS000080E06D_32630 15907467 32630 uugacuagcc .......... .......... Ro autoantigen complexed with RNAs; Y RNA sequence, second strand 1yxp A 23 2.4 URS000080E167_32630 16403527 32630 cungcugaagugcacacagcaag <<<<<<<.........>>>>>>> (((((((.........))))))) HIV-1 DIS RNA subtype F- Zn soaked; 5'-R(*CP*UP*(5BU)P*GP*CP*UP*GP*AP*AP*GP*UP*GP*CP*AP*CP*AP*CP*AP*GP*CP*AP*AP*G)-3' 1yxp B 23 2.4 URS000080E167_32630 16403527 32630 cungcugaagugcacacagcaag <<<<<<<.........>>>>>>> (((((((.........))))))) HIV-1 DIS RNA subtype F- Zn soaked; 5'-R(*CP*UP*(5BU)P*GP*CP*UP*GP*AP*AP*GP*UP*GP*CP*AP*CP*AP*CP*AP*GP*CP*AP*AP*G)-3' 1yy0 A 16 3.2 URS000080DF42_32630 16190727 32630 gcaganuuaaaucugc ................ ................ Crystal structure of an RNA duplex containing a 2'-amine substitution and a 2'-amide product produced by in-crystal acylation at a C-A mismatch; 5'-R(*GP*CP*AP*GP*AP*(A5M)P*UP*UP*AP*AP*AP*UP*CP*UP*GP*C)-3' 1yy0 B 16 3.2 URS000080DF42_32630 16190727 32630 gcaganuuaaaucugc ................ ................ Crystal structure of an RNA duplex containing a 2'-amine substitution and a 2'-amide product produced by in-crystal acylation at a C-A mismatch; 5'-R(*GP*CP*AP*GP*AP*(M5M)P*UP*UP*AP*AP*AP*UP*CP*UP*GP*C)-3' 1yy0 C 16 3.2 URS000080DF42_32630 16190727 32630 gcaganuuaaaucugc ................ ................ Crystal structure of an RNA duplex containing a 2'-amine substitution and a 2'-amide product produced by in-crystal acylation at a C-A mismatch; 5'-R(*GP*CP*AP*GP*AP*(A5M)P*UP*UP*AP*AP*AP*UP*CP*UP*GP*C)-3' 1yyk C 12 2.5 URS000080DE83_32630 16216575 32630 cgcgaauucgcg ............ ............ Crystal structure of RNase III from Aquifex Aeolicus complexed with double-stranded RNA at 2.5-angstrom resolution; 5'-R(*CP*GP*CP*GP*AP*AP*UP*UP*CP*GP*CP*G)-3' 1yyk D 12 2.5 URS000080DE83_32630 16216575 32630 cgcgaauucgcg ............ ............ Crystal structure of RNase III from Aquifex Aeolicus complexed with double-stranded RNA at 2.5-angstrom resolution; 5'-R(*CP*GP*CP*GP*AP*AP*UP*UP*CP*GP*CP*G)-3' 1yyk E 12 2.5 URS000080DE83_32630 16216575 32630 cgcgaauucgcg ............ ............ Crystal structure of RNase III from Aquifex Aeolicus complexed with double-stranded RNA at 2.5-angstrom resolution; 5'-R(*CP*GP*CP*GP*AP*AP*UP*UP*CP*GP*CP*G)-3' 1yyk F 12 2.5 URS000080DE83_32630 16216575 32630 cgcgaauucgcg ............ ............ Crystal structure of RNase III from Aquifex Aeolicus complexed with double-stranded RNA at 2.5-angstrom resolution; 5'-R(*CP*GP*CP*GP*AP*AP*UP*UP*CP*GP*CP*G)-3' 1yyo C 12 2.9 URS000080DE83_32630 16216575 32630 cgcgaauucgcg ............ ............ Crystal structure of RNase III mutant E110K from Aquifex aeolicus complexed with double-stranded RNA at 2.9-Angstrom Resolution; 5'-R(*CP*GP*CP*GP*AP*AP*UP*UP*CP*GP*CP*G)-3' 1yyo D 12 2.9 URS000080DE83_32630 16216575 32630 cgcgaauucgcg ............ ............ Crystal structure of RNase III mutant E110K from Aquifex aeolicus complexed with double-stranded RNA at 2.9-Angstrom Resolution; 5'-R(*CP*GP*CP*GP*AP*AP*UP*UP*CP*GP*CP*G)-3' 1yyo E 12 2.9 URS000080DE83_32630 16216575 32630 cgcgaauucgcg ............ ............ Crystal structure of RNase III mutant E110K from Aquifex aeolicus complexed with double-stranded RNA at 2.9-Angstrom Resolution; 5'-R(*CP*GP*CP*GP*AP*AP*UP*UP*CP*GP*CP*G)-3' 1yyo F 12 2.9 URS000080DE83_32630 16216575 32630 cgcgaauucgcg ............ ............ Crystal structure of RNase III mutant E110K from Aquifex aeolicus complexed with double-stranded RNA at 2.9-Angstrom Resolution; 5'-R(*CP*GP*CP*GP*AP*AP*UP*UP*CP*GP*CP*G)-3' 1yyw E 12 2.8 URS000080E28A_32630 16216575 32630 aaauauauauuu ............ ............ Crystal structure of RNase III from Aquifex aeolicus complexed with double stranded RNA at 2.8-Angstrom Resolution; 5'-R(*AP*AP*AP*UP*AP*UP*AP*UP*AP*UP*UP*U)-3' 1yyw F 12 2.8 URS000080E28A_32630 16216575 32630 aaauauauauuu ............ ............ Crystal structure of RNase III from Aquifex aeolicus complexed with double stranded RNA at 2.8-Angstrom Resolution; 5'-R(*AP*AP*AP*UP*AP*UP*AP*UP*AP*UP*UP*U)-3' 1yyw G 12 2.8 URS000080E28A_32630 16216575 32630 aaauauauauuu ............ ............ Crystal structure of RNase III from Aquifex aeolicus complexed with double stranded RNA at 2.8-Angstrom Resolution; 5'-R(*AP*AP*AP*UP*AP*UP*AP*UP*AP*UP*UP*U)-3' 1yyw H 12 2.8 URS000080E28A_32630 16216575 32630 aaauauauauuu ............ ............ Crystal structure of RNase III from Aquifex aeolicus complexed with double stranded RNA at 2.8-Angstrom Resolution; 5'-R(*AP*AP*AP*UP*AP*UP*AP*UP*AP*UP*UP*U)-3' 1yyw I 12 2.8 URS000080E28A_32630 16216575 32630 aaauauauauuu ............ ............ Crystal structure of RNase III from Aquifex aeolicus complexed with double stranded RNA at 2.8-Angstrom Resolution; 5'-R(*AP*AP*AP*UP*AP*UP*AP*UP*AP*UP*UP*U)-3' 1yyw J 12 2.8 URS000080E28A_32630 16216575 32630 aaauauauauuu ............ ............ Crystal structure of RNase III from Aquifex aeolicus complexed with double stranded RNA at 2.8-Angstrom Resolution; 5'-R(*AP*AP*AP*UP*AP*UP*AP*UP*AP*UP*UP*U)-3' 1yyw K 12 2.8 URS000080E28A_32630 16216575 32630 aaauauauauuu ............ ............ Crystal structure of RNase III from Aquifex aeolicus complexed with double stranded RNA at 2.8-Angstrom Resolution; 5'-R(*AP*AP*AP*UP*AP*UP*AP*UP*AP*UP*UP*U)-3' 1yyw L 12 2.8 URS000080E28A_32630 16216575 32630 aaauauauauuu ............ ............ Crystal structure of RNase III from Aquifex aeolicus complexed with double stranded RNA at 2.8-Angstrom Resolution; 5'-R(*AP*AP*AP*UP*AP*UP*AP*UP*AP*UP*UP*U)-3' 1yz9 C 11 2.1 URS000080E0A2_32630 16216575 32630 cgaacuucgcg ........... ........... Crystal structure of RNase III mutant E110Q from Aquifex aeolicus complexed with double stranded RNA at 2.1-Angstrom Resolution; 5'-R(*CP*GP*AP*AP*CP*UP*UP*CP*GP*CP*G)-3' 1yz9 D 11 2.1 URS000080E0A2_32630 16216575 32630 cgaacuucgcg ........... ........... Crystal structure of RNase III mutant E110Q from Aquifex aeolicus complexed with double stranded RNA at 2.1-Angstrom Resolution; 5'-R(*CP*GP*AP*AP*CP*UP*UP*CP*GP*CP*G)-3' 1yz9 E 11 2.1 URS000080E0A2_32630 16216575 32630 cgaacuucgcg ........... ........... Crystal structure of RNase III mutant E110Q from Aquifex aeolicus complexed with double stranded RNA at 2.1-Angstrom Resolution; 5'-R(*CP*GP*AP*AP*CP*UP*UP*CP*GP*CP*G)-3' 1yz9 F 11 2.1 URS000080E0A2_32630 16216575 32630 cgaacuucgcg ........... ........... Crystal structure of RNase III mutant E110Q from Aquifex aeolicus complexed with double stranded RNA at 2.1-Angstrom Resolution; 5'-R(*CP*GP*AP*AP*CP*UP*UP*CP*GP*CP*G)-3' 1yzd B 16 2.35 URS000080DF15_32630 16190727 32630 gcaganuuaagucugc ................ ................ Crystal structure of an RNA duplex containing a site specific 2'-amine substitution at a C-G Watson-Crick base pair; RNA 5'-R(*GP*CP*AP*GP*AP*(A5M)P*UP*UP*AP*AP*GP*UP*CP*UP*GP*C)-3' 1yzd A 16 2.35 URS000080DF15_32630 16190727 32630 gcaganuuaagucugc ................ ................ Crystal structure of an RNA duplex containing a site specific 2'-amine substitution at a C-G Watson-Crick base pair; RNA 5'-R(*GP*CP*AP*GP*AP*(A5M)P*UP*UP*AP*AP*GP*UP*CP*UP*GP*C)-3' 1yzd C 16 2.35 URS000080DF15_32630 16190727 32630 gcaganuuaagucugc ................ ................ Crystal structure of an RNA duplex containing a site specific 2'-amine substitution at a C-G Watson-Crick base pair; RNA 5'-R(*GP*CP*AP*GP*AP*(A5M)P*UP*UP*AP*AP*GP*UP*CP*UP*GP*C)-3' 1z79 B 16 2.55 URS000080DF42_32630 16190727 32630 gcaganuuaaaucugc ................ ................ Crystal structure of an RNA duplex containing site specific 2'-amine substitution at a C-A mismatch (at pH 5); RNA 5'-R(*GP*CP*AP*GP*AP*(A5M)P*UP*UP*AP*AP*AP*UP*CP*UP*GP*C)-3' 1z79 A 16 2.55 URS000080DF42_32630 16190727 32630 gcaganuuaaaucugc ................ ................ Crystal structure of an RNA duplex containing site specific 2'-amine substitution at a C-A mismatch (at pH 5); RNA 5'-R(*GP*CP*AP*GP*AP*(A5M)P*UP*UP*AP*AP*AP*UP*CP*UP*GP*C)-3' 1z79 C 16 2.55 URS000080DF42_32630 16190727 32630 gcaganuuaaaucugc ................ ................ Crystal structure of an RNA duplex containing site specific 2'-amine substitution at a C-A mismatch (at pH 5); RNA 5'-R(*GP*CP*AP*GP*AP*(A5M)P*UP*UP*AP*AP*AP*UP*CP*UP*GP*C)-3' 1z7f A 16 2.1 URS000080DF42_32630 16190727 32630 gcagacuuaaaucugc ................ ................ Crystal structure of 16 base pair RNA duplex containing a C-A mismatch; 5'-R(*GP*CP*AP*GP*AP*CP*UP*UP*AP*AP*AP*UP*CP*UP*GP*C)-3' 1z7f B 16 2.1 URS000080DF42_32630 16190727 32630 gcagacuuaaaucugc ................ ................ Crystal structure of 16 base pair RNA duplex containing a C-A mismatch; 5'-R(*GP*CP*AP*GP*AP*CP*UP*UP*AP*AP*AP*UP*CP*UP*GP*C)-3' 1z7f C 16 2.1 URS000080DF42_32630 16190727 32630 gcagacuuaaaucugc ................ ................ Crystal structure of 16 base pair RNA duplex containing a C-A mismatch; 5'-R(*GP*CP*AP*GP*AP*CP*UP*UP*AP*AP*AP*UP*CP*UP*GP*C)-3' 1zci A 23 1.65 URS000080E167_32630 16403527 32630 cnugcugaagugcacacagcaag <<<<<<<.........>>>>>>> (((((((.........))))))) HIV-1 DIS RNA subtype F- monoclinic form; 5'-R(*CP*(5BU)P*UP*GP*CP*UP*GP*AP*AP*GP*UP*GP*CP*AP*CP*AP*CP*AP*GP*CP*AP*AP*G)-3' 1zci B 23 1.65 URS000080E167_32630 16403527 32630 cnugcugaagugcacacagcaag <<<<<<<.........>>>>>>> (((((((.........))))))) HIV-1 DIS RNA subtype F- monoclinic form; 5'-R(*CP*(5BU)P*UP*GP*CP*UP*GP*AP*AP*GP*UP*GP*CP*AP*CP*AP*CP*AP*GP*CP*AP*AP*G)-3' 1zci C 23 1.65 URS000080E167_32630 16403527 32630 cnugcugaagugcacacagcaag <<<<<<<.........>>>>>>> (((((((.........))))))) HIV-1 DIS RNA subtype F- monoclinic form; 5'-R(*CP*(5BU)P*UP*GP*CP*UP*GP*AP*AP*GP*UP*GP*CP*AP*CP*AP*CP*AP*GP*CP*AP*AP*G)-3' 1zci D 23 1.65 URS000080E167_32630 16403527 32630 cnugcugaagugcacacagcaag <<<<<<<.........>>>>>>> (((((((.........))))))) HIV-1 DIS RNA subtype F- monoclinic form; 5'-R(*CP*(5BU)P*UP*GP*CP*UP*GP*AP*AP*GP*UP*GP*CP*AP*CP*AP*CP*AP*GP*CP*AP*AP*G)-3' 1zdh S 13 2.7 URS000080DD3D_32630 9245600,7523953,8254664 32630 ugaggaucaccca <<.<<....>>>> ((.((....)))) MS2 COAT PROTEIN/RNA COMPLEX; RNA (5'-R(*AP*CP*AP*UP*GP*AP*GP*GP*AP*UP*CP*AP*CP*CP*CP*AP*U P*GP*U)-3') 1zdi S 13 2.7 URS000080DDB6_32630 9245600,7523953,8254664 32630 ugaggauuaccca <<.<<....>>>> ((.((....)))) RNA BACTERIOPHAGE MS2 COAT PROTEIN/RNA COMPLEX; RNA (5'-R(*AP*CP*AP*UP*GP*AP*GP*GP*AP*UP*UP*AP*CP*CP*CP*AP*U P*GP*U)-3') 1zdk S 19 2.86 URS000080DD3D_32630 9917072 32630 acaugaggaucacccaugu <<<<<.<<....>>>>>>> (((((.((....))))))) STRUCTURE OF BACTERIOPHAGE COAT PROTEIN-LOOP RNA COMPLEX; RNA (5'-R(P*AP*CP*AP*UP*GP*AP*GP*GP*AP*UP*CP*AP*CP*CP*CP*AP*UP*GP*U)-3') 1zev A 18 1.58 URS000080DEA4_32630 16269545 32630 cugcugcugcugcugcug .................. .................. Crystal Structure of a Pathogenic RNA: CUG Repeats; 5'-R(*CP*UP*GP*CP*UP*GP*CP*UP*GP*CP*UP*GP*CP*UP*GP*CP*UP*G)-3' 1zev B 18 1.58 URS000080DEA4_32630 16269545 32630 cugcugcugcugcugcug .................. .................. Crystal Structure of a Pathogenic RNA: CUG Repeats; 5'-R(*CP*UP*GP*CP*UP*GP*CP*UP*GP*CP*UP*GP*CP*UP*GP*CP*UP*G)-3' 1zft A 13 2.33 URS000080E09E_32630 16411744 32630 ucccnguccaccg ............. ............. The crystal structure of an all-RNA minimal Hairpin Ribozyme with mutant G8I at the cleavage site; 5'-R(*UP*CP*CP*CP*(A2M)P*GP*UP*CP*CP*AP*CP*CP*G)-3' 1zft B 12 2.33 URS000080E1BF_32630 16411744 32630 cggugaiaaggg ............ ............ The crystal structure of an all-RNA minimal Hairpin Ribozyme with mutant G8I at the cleavage site; 5'-R(*CP*GP*GP*UP*GP*AP*IP*AP*AP*GP*GP*G)-3' 1zft C 17 2.33 URS000080DEF8_32630 16411744 32630 ggcagagaaacacacga ................. ................. The crystal structure of an all-RNA minimal Hairpin Ribozyme with mutant G8I at the cleavage site; 5'-R(*GP*GP*CP*AP*GP*AP*GP*AP*AP*AP*CP*AP*CP*AP*CP*GP*A)-3' 1zft D 19 2.33 URS000080E34C_32630 16411744 32630 ucgugguacauuaccugcc ................... ................... The crystal structure of an all-RNA minimal Hairpin Ribozyme with mutant G8I at the cleavage site; 5'-R(*UP*CP*GP*UP*GP*GP*UP*AP*CP*AP*UP*UP*AP*CP*CP*UP*GP*CP*C)-3' 1zfv A 13 2.4 URS000080E09E_32630 16411744 32630 ucccaguccaccg ............. ............. The structure of an all-RNA minimal Hairpin Ribozyme with Mutation G8A at the cleavage site; 5'-R(*UP*CP*CP*CP*AP*GP*UP*CP*CP*AP*CP*CP*G)-3' 1zfv B 12 2.4 URS000080DDAC_32630 16411744 32630 cggugaaaaggg ............ ............ The structure of an all-RNA minimal Hairpin Ribozyme with Mutation G8A at the cleavage site; 5'-R(*CP*GP*GP*UP*GP*AP*AP*AP*AP*GP*GP*G)-3' 1zfv C 17 2.4 URS000080DEF8_32630 16411744 32630 ggcagagaaacacacga ................. ................. The structure of an all-RNA minimal Hairpin Ribozyme with Mutation G8A at the cleavage site; 5'-R(*GP*GP*CP*AP*GP*AP*GP*AP*AP*AP*CP*AP*CP*AP*CP*GP*A)-3' 1zfv D 19 2.4 URS000080E34C_32630 16411744 32630 ucgugguacauuaccugcc ................... ................... The structure of an all-RNA minimal Hairpin Ribozyme with Mutation G8A at the cleavage site; 5'-R(*UP*CP*GP*UP*GP*GP*UP*AP*CP*AP*UP*UP*AP*CP*CP*UP*GP*CP*C)-3' 1zfx A 13 2.38 URS000080E09E_32630 16411744 32630 ucccaguccaccg ............. ............. The Structure of a minimal all-RNA Hairpin Ribozyme with the mutant G8U at the cleavage site; 5'-R(*UP*CP*CP*CP*AP*GP*UP*CP*CP*AP*CP*CP*G)-3' 1zfx B 12 2.38 URS000080DF3D_32630 16411744 32630 cggugauaaggg ............ ............ The Structure of a minimal all-RNA Hairpin Ribozyme with the mutant G8U at the cleavage site; 5'-R(*CP*GP*GP*UP*GP*AP*UP*AP*AP*GP*GP*G)-3' 1zfx C 17 2.38 URS000080DEF8_32630 16411744 32630 ggcagagaaacacacga ................. ................. The Structure of a minimal all-RNA Hairpin Ribozyme with the mutant G8U at the cleavage site; 5'-R(*GP*GP*CP*AP*GP*AP*GP*AP*AP*AP*CP*AP*CP*AP*CP*GP*A)-3' 1zfx D 19 2.38 URS000080E34C_32630 16411744 32630 ucgugguacauuaccugcc ................... ................... The Structure of a minimal all-RNA Hairpin Ribozyme with the mutant G8U at the cleavage site; 5'-R(*UP*CP*GP*UP*GP*GP*UP*AP*CP*AP*UP*UP*AP*CP*CP*UP*GP*CP*C)-3' 1zo3 A 76 13.8 RF00005 URS000011107D_562 15935757 0030533 0006412 562 gcggauuuagcucaguugggagagcgccagacugaagaucuggagguccuguguucgauccacagaauucgcacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((.........)))).....(((((..]....)))))))))))).... The P-site and P/E-site tRNA structures fitted to P/I site codon.; tRNA 1zo3 B 76 13.8 RF00005 URS000011107D_562 15935757 0030533 0006412 562 gcggauuuagcucaguugggagagcgccagacugaagaucuggagguccuguguucgauccacagaauucgcacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((.........)))).....(((((..]....)))))))))))).... The P-site and P/E-site tRNA structures fitted to P/I site codon.; tRNA 1zx7 A 15 2.15 URS000080E2C8_32630 16037995 32630 guggugaagucgcgg ............... ............... Molecular Recognition of RNA by Neomycin and a Restricted Neomycin Derivative; 5'-R(*GP*UP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*CP*GP*G)-3' 1zx7 B 14 2.15 URS000080E37D_32630 16037995 32630 cgcgucacaccacc .............. .............. Molecular Recognition of RNA by Neomycin and a Restricted Neomycin Derivative; 5'-R(*CP*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*AP*CP*C)-3' 1zx7 C 15 2.15 URS000080E2C8_32630 16037995 32630 guggugaagucgcgg ............... ............... Molecular Recognition of RNA by Neomycin and a Restricted Neomycin Derivative; 5'-R(*GP*UP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*CP*GP*G)-3' 1zx7 D 14 2.15 URS000080E37D_32630 16037995 32630 cgcgucacaccacc .............. .............. Molecular Recognition of RNA by Neomycin and a Restricted Neomycin Derivative; 5'-R(*CP*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*AP*CP*C)-3' 1zx7 E 15 2.15 URS000080E2C8_32630 16037995 32630 guggugaagucgcgg ............... ............... Molecular Recognition of RNA by Neomycin and a Restricted Neomycin Derivative; 5'-R(*GP*UP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*CP*GP*G)-3' 1zx7 F 14 2.15 URS000080E37D_32630 16037995 32630 cgcgucacaccacc .............. .............. Molecular Recognition of RNA by Neomycin and a Restricted Neomycin Derivative; 5'-R(*CP*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*AP*CP*C)-3' 1zx7 G 15 2.15 URS000080E2C8_32630 16037995 32630 guggugaagucgcgg ............... ............... Molecular Recognition of RNA by Neomycin and a Restricted Neomycin Derivative; 5'-R(*GP*UP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*CP*GP*G)-3' 1zx7 H 14 2.15 URS000080E37D_32630 16037995 32630 cgcgucacaccacc .............. .............. Molecular Recognition of RNA by Neomycin and a Restricted Neomycin Derivative; 5'-R(*CP*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*AP*CP*C)-3' 1zz5 A 15 3.0 URS000080E2C8_32630 16037995 32630 guggugaagucgcgg ............... ............... Molecular Recognition of RNA by Neomycin and a Restricted Neomycin Derivative; 5'-R(*GP*UP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*CP*GP*G)-3' 1zz5 B 14 3.0 URS000080E37D_32630 16037995 32630 cgcgucacaccacc .............. .............. Molecular Recognition of RNA by Neomycin and a Restricted Neomycin Derivative; 5'-R(*CP*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*AP*CP*C)-3' 1zz5 C 15 3.0 URS000080E2C8_32630 16037995 32630 guggugaagucgcgg ............... ............... Molecular Recognition of RNA by Neomycin and a Restricted Neomycin Derivative; 5'-R(*GP*UP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*CP*GP*G)-3' 1zz5 D 14 3.0 URS000080E37D_32630 16037995 32630 cgcgucacaccacc .............. .............. Molecular Recognition of RNA by Neomycin and a Restricted Neomycin Derivative; 5'-R(*CP*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*AP*CP*C)-3' 1zzn B 197 3.37 RF00028 URS000080E37C_32630 16141079,15175762,15547134,6101203 0000372 32630 ngccgugugccuugcgccgggaaaccacgcaagggauggugucaaauucggcgaaaccuaagcgcccgcccgggcguauggcaacgccgagccaagcuucgcagccauugcacuccggcugcgaugaagguguagagacuagacggcacccaccuaaggcaaacgcuauggugaaggcauaguccagggaguggcgn .........<<<<<<<..<<....>>.>>>>>>>...<<<<<<....<<<<<<...<<...<<<<<<....>>>>>>..>>...>>>>>><<<.....<<<<<<<<..........>>>>>>>>....>>>.....(((((...>>>>>><<<<...<<<....>>>..>>>>......)))))............. .........(((((((..((....)).)))))))...((((((....((((((...((...((((((....))))))..))...))))))(((...(.((((((((..........)))))))).)..)))...[.[[[[[...))))))((((...(((....)))..))))......]]]]]]............ Crystal structure of a group I intron/two exon complex that includes all catalytic metal ion ligands.; 197-MER 1zzn C 22 3.37 URS000080E339_32630 16141079,15175762,15547134,6101203 32630 aagccacacaaaccagacggcc ...................... ...................... Crystal structure of a group I intron/two exon complex that includes all catalytic metal ion ligands.; 5'-R(*AP*AP*GP*CP*CP*AP*CP*AP*CP*AP*AP*AP*CP*CP*AP*GP*AP*CP*GP*GP*CP*C)-3' 205d A 12 2.64 URS000080E26D_32630 7719854 32630 ggacuuuggucc ............ ............ STRUCTURE OF AN RNA DOUBLE HELIX INCLUDING URACIL-URACIL BASE PAIRS IN AN INTERNAL LOOP; RNA (5'-R(*GP*GP*AP*CP*UP*UP*UP*GP*GP*UP*CP*C)-3') 205d B 12 2.64 URS000080E26D_32630 7719854 32630 ggacuuuggucc ............ ............ STRUCTURE OF AN RNA DOUBLE HELIX INCLUDING URACIL-URACIL BASE PAIRS IN AN INTERNAL LOOP; RNA (5'-R(*GP*GP*AP*CP*UP*UP*UP*GP*GP*UP*CP*C)-3') 247d A 11 2.8 8807843 gcgatatacgc ........... ........... CRYSTAL STRUCTURES OF AN A-FORM DUPLEX WITH SINGLE-ADENOSINE BULGES AND A CONFORMATIONAL BASIS FOR SITE SPECIFIC RNA SELF-CLEAVAGE; DNA/RNA (5'-R(*GP*CP*GP*)-D(*AP*TP*AP*TP*AP*)-R(*CP*GP*C)-3') 248d A 11 1.83 8807843 gcgatatacgc ........... ........... CRYSTAL STRUCTURES OF AN A-FORM DUPLEX WITH SINGLE-ADENOSINE BULGES AND A CONFORMATIONAL BASIS FOR SITE SPECIFIC RNA SELF-CLEAVAGE; DNA/RNA (5'-R(*GP*CP*GP*)-D(*AP*TP*AP*TP*AP*)-R(*CP*GP*C)-3'), ORTHORHOMBIC 255d A 12 2.0 URS000080DD82_32630 1922368 32630 ggacuucggucc ............ ............ CRYSTAL STRUCTURE OF AN RNA DOUBLE HELIX INCORPORATING A TRACK OF NON-WATSON-CRICK BASE PAIRS; RNA (5'-R(*GP*GP*AP*CP*UP*UP*CP*GP*GP*UP*CP*C)-3') 280d A 12 2.4 URS000080E1E2_32630 8805576 32630 ggcgcuugcguc ............ ............ THE STRUCTURE OF AN RNA DODECAMER SHOWS HOW TANDEM U-U BASE PAIRS INCREASE THE RANGE OF STABLE RNA STRUCTURES AND THE DIVERSITY OF RECOGNITION SITES; RNA (5'-R(*GP*GP*CP*GP*CP*UP*UP*GP*CP*GP*UP*C)-3') 280d B 12 2.4 URS000080E1E2_32630 8805576 32630 ggcgcuugcguc ............ ............ THE STRUCTURE OF AN RNA DODECAMER SHOWS HOW TANDEM U-U BASE PAIRS INCREASE THE RANGE OF STABLE RNA STRUCTURES AND THE DIVERSITY OF RECOGNITION SITES; RNA (5'-R(*GP*GP*CP*GP*CP*UP*UP*GP*CP*GP*UP*C)-3') 280d C 12 2.4 URS000080E1E2_32630 8805576 32630 ggcgcuugcguc ............ ............ THE STRUCTURE OF AN RNA DODECAMER SHOWS HOW TANDEM U-U BASE PAIRS INCREASE THE RANGE OF STABLE RNA STRUCTURES AND THE DIVERSITY OF RECOGNITION SITES; RNA (5'-R(*GP*GP*CP*GP*CP*UP*UP*GP*CP*GP*UP*C)-3') 280d D 12 2.4 URS000080E1E2_32630 8805576 32630 ggcgcuugcguc ............ ............ THE STRUCTURE OF AN RNA DODECAMER SHOWS HOW TANDEM U-U BASE PAIRS INCREASE THE RANGE OF STABLE RNA STRUCTURES AND THE DIVERSITY OF RECOGNITION SITES; RNA (5'-R(*GP*GP*CP*GP*CP*UP*UP*GP*CP*GP*UP*C)-3') 283d A 12 2.3 URS000080DE79_32630 8917508 32630 ggccgaaaggcc ............ ............ A CURVED RNA HELIX INCORPORATING AN INTERNAL LOOP WITH G-A AND A-A NON-WATSON-CRICK BASE PAIRING; RNA (5'-R(*GP*GP*CP*CP*GP*AP*AP*AP*GP*GP*CP*C)-3') 299d A 16 3.0 URS000080DF69_32630 8953035 32630 guggucugaugaggcc ................ ................ CAPTURING THE STRUCTURE OF A CATALYTIC RNA INTERMEDIATE: THE HAMMERHEAD RIBOZYME; RNA HAMMERHEAD RIBOZYME 299d B 25 3.0 URS000080E0D1_32630 8953035 32630 ggccgaaacucguaagagucaccac ........<<<....>>>....... .......((((....))))...... CAPTURING THE STRUCTURE OF A CATALYTIC RNA INTERMEDIATE: THE HAMMERHEAD RIBOZYME; RNA HAMMERHEAD RIBOZYME 2a04 A 15 2.95 URS000080E2C8_32630 16037995 32630 guggugaagucgcgg ............... ............... Molecular Recognition of RNA by Neomycin and a Restricted Neomycin Derivative; 5'-R(*GP*UP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*CP*GP*G)-3' 2a04 B 14 2.95 URS000080E37D_32630 16037995 32630 cgcgucacaccacc .............. .............. Molecular Recognition of RNA by Neomycin and a Restricted Neomycin Derivative; 5'-R(*CP*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*AP*CP*C)-3' 2a04 C 15 2.95 URS000080E2C8_32630 16037995 32630 guggugaagucgcgg ............... ............... Molecular Recognition of RNA by Neomycin and a Restricted Neomycin Derivative; 5'-R(*GP*UP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*CP*GP*G)-3' 2a04 D 14 2.95 URS000080E37D_32630 16037995 32630 cgcgucacaccacc .............. .............. Molecular Recognition of RNA by Neomycin and a Restricted Neomycin Derivative; 5'-R(*CP*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*AP*CP*C)-3' 2adt A 43 NA URS000080DD2F_32630 16002091 32630 gggauauggaagaaccggggaaacuugguucuuccuaaguccu <<<<<..<<<<<<<<<<<......>>>>>>>>>>>...>>>>> (((((..((((((((((((....))))))))))))...))))) NMR structure of a 30 kDa GAAA tetraloop-receptor complex.; 43-MER 2adt B 43 NA URS000080DD2F_32630 16002091 32630 gggauauggaagaaccggggaaacuugguucuuccuaaguccu <<<<<..<<<<<<<<<<<......>>>>>>>>>>>...>>>>> (((((..((((((((((((....))))))))))))...))))) NMR structure of a 30 kDa GAAA tetraloop-receptor complex.; 43-MER 2ao5 A 10 2.1 URS000080DFE1_32630 16510980 32630 ggcgngcgcu .......... .......... Crystal structure of an RNA duplex r(GGCGBrUGCGCU)2 with terminal and internal tandem G-U base pairs; 5'-R(*GP*GP*CP*GP*(5BU)P*GP*CP*GP*CP*U)-3' 2ao5 B 10 2.1 URS000080DFE1_32630 16510980 32630 ggcgngcgcu .......... .......... Crystal structure of an RNA duplex r(GGCGBrUGCGCU)2 with terminal and internal tandem G-U base pairs; 5'-R(*GP*GP*CP*GP*(5BU)P*GP*CP*GP*CP*U)-3' 2ao5 C 10 2.1 URS000080DFE1_32630 16510980 32630 ggcgngcgcu .......... .......... Crystal structure of an RNA duplex r(GGCGBrUGCGCU)2 with terminal and internal tandem G-U base pairs; 5'-R(*GP*GP*CP*GP*(5BU)P*GP*CP*GP*CP*U)-3' 2ao5 D 10 2.1 URS000080DFE1_32630 16510980 32630 ggcgngcgcu .......... .......... Crystal structure of an RNA duplex r(GGCGBrUGCGCU)2 with terminal and internal tandem G-U base pairs; 5'-R(*GP*GP*CP*GP*(5BU)P*GP*CP*GP*CP*U)-3' 2az0 C 18 2.6 URS000080DDF7_32630 16228003 32630 gcanggacgcgnccangc .................. .................. Flock House virus B2-dsRNA Complex (P212121); 5'-R(*GP*CP*AP*(5BU)P*GP*GP*AP*CP*GP*CP*GP*(5BU)P*CP*CP*AP*(5BU)P*GP*C)-3' 2az0 D 18 2.6 URS000080DDF7_32630 16228003 32630 gcanggacgcgnccangc .................. .................. Flock House virus B2-dsRNA Complex (P212121); 5'-R(*GP*CP*AP*(5BU)P*GP*GP*AP*CP*GP*CP*GP*(5BU)P*CP*CP*AP*(5BU)P*GP*C)-3' 2az2 C 18 2.6 URS000080DDF7_32630 16228003 32630 gcanggacgcgnccangc .................. .................. Flock House virus B2-dsRNA Complex (P4122); 5'-R(*GP*CP*AP*(5BU)P*GP*GP*AP*CP*GP*CP*GP*(5BU)P*CP*CP*AP*(5BU)P*GP*C)-3' 2az2 D 18 2.6 URS000080DDF7_32630 16228003 32630 gcanggacgcgnccangc .................. .................. Flock House virus B2-dsRNA Complex (P4122); 5'-R(*GP*CP*AP*(5BU)P*GP*GP*AP*CP*GP*CP*GP*(5BU)P*CP*CP*AP*(5BU)P*GP*C)-3' 2b2e S 14 3.15 URS000080DDB6_32630 16531233 32630 ugaggauuacccau <<.<<....>>>>. ((.((....)))). RNA stemloop from bacteriophage MS2 complexed with an N87S,E89K mutant MS2 capsid; 5'-R(*AP*CP*AP*UP*GP*AP*GP*GP*AP*UP*UP*AP*CP*CP*CP*AP*UP*GP*U)-3' 2b2g S 15 3.02 URS000080DDB6_32630 16531233 32630 augaggauuacccau <<<.<<....>>>>> (((.((....))))) MS2 Wild-type RNA stemloop complexed with an N87S mutant MS2 capsid; 5'-R(*AP*CP*AP*UP*GP*AP*GP*GP*AP*UP*UP*AP*CP*CP*CP*AP*UP*GP*U)-3' 2b8r A 23 2.6 URS000080DD3F_32630 11702070 32630 cuugcugaagcgcgcacggcaag <<<<<<<.........>>>>>>> (((((((.........))))))) Structure oF HIV-1(LAI) genomic RNA DIS; 5'-R(*CP*UP*UP*GP*CP*UP*GP*AP*AP*GP*CP*GP*CP*GP*CP*AP*CP*GP*GP*CP*AP*AP*G)-3' 2b8r B 23 2.6 URS000080DD3F_32630 11702070 32630 cuugcugaagcgcgcacggcaag <<<<<<<.........>>>>>>> (((((((.........))))))) Structure oF HIV-1(LAI) genomic RNA DIS; 5'-R(*CP*UP*UP*GP*CP*UP*GP*AP*AP*GP*CP*GP*CP*GP*CP*AP*CP*GP*GP*CP*AP*AP*G)-3' 2b8s A 23 2.76 URS000080E21C_32630 11702070 32630 cuugcugaggugcacacagcaag <<<<<<<.........>>>>>>> (((((((.........))))))) Structure of HIV-1(MAL) genomic RNA DIS; 5'-R(*CP*UP*UP*GP*CP*UP*GP*AP*GP*GP*UP*GP*CP*AP*CP*AP*CP*AP*GP*CP*AP*AP*G)-3' 2b8s B 23 2.76 URS000080E21C_32630 11702070 32630 cuugcugaggugcacacagcaag <<<<<<<.........>>>>>>> (((((((.........))))))) Structure of HIV-1(MAL) genomic RNA DIS; 5'-R(*CP*UP*UP*GP*CP*UP*GP*AP*GP*GP*UP*GP*CP*AP*CP*AP*CP*AP*GP*CP*AP*AP*G)-3' 2bbv N 10 2.8 URS000080E1B1_32630 8289282 32630 ucuuauaucu .......... .......... THE REFINED THREE-DIMENSIONAL STRUCTURE OF AN INSECT VIRUS AT 2.8 ANGSTROMS RESOLUTION; RNA (5'-R(*UP*CP*UP*UP*AP*UP*AP*UP*CP*U)-3') 2bcy A 13 2.7 URS000080E09E_32630 16411744 32630 ucccaguccaccg ............. ............. Crystal Structure of a minimal, mutant all-RNA hairpin ribozyme (U39C, G8MTU); 5'-R(*UP*CP*CP*CP*AP*GP*UP*CP*CP*AP*CP*CP*G)-3' 2bcy B 12 2.7 URS000080DDAC_32630 16411744 32630 cgguganaaggg ............ ............ Crystal Structure of a minimal, mutant all-RNA hairpin ribozyme (U39C, G8MTU); 5'-R(*CP*GP*GP*UP*GP*AP*(MTU)P*AP*AP*GP*GP*G)-3' 2bcy C 17 2.7 URS000080DEF8_32630 16411744 32630 ggcagagaaacacacga ................. ................. Crystal Structure of a minimal, mutant all-RNA hairpin ribozyme (U39C, G8MTU); 5'-R(*GP*GP*CP*AP*GP*AP*GP*AP*AP*AP*CP*AP*CP*AP*CP*GP*A)-3' 2bcy D 19 2.7 URS000080E34C_32630 16411744 32630 ucgugguacauuaccugcc ................... ................... Crystal Structure of a minimal, mutant all-RNA hairpin ribozyme (U39C, G8MTU); 5'-R(*UP*CP*GP*UP*GP*GP*UP*AP*CP*AP*UP*UP*AP*CP*CP*UP*GP*CP*C)-3' 2bcz A 13 2.4 URS000080E09E_32630 16411744 32630 ucccaguccaccg ............. ............. Crystal Structure of a minimal, mutant all-RNA hairpin ribozyme (U39C, G8I, 2'deoxy A-1); 5'-R(*UP*CP*CP*CP*(DA)P*GP*UP*CP*CP*AP*CP*CP*G)-3') 2bcz B 12 2.4 URS000080E1BF_32630 16411744 32630 cggugaiaaggg ............ ............ Crystal Structure of a minimal, mutant all-RNA hairpin ribozyme (U39C, G8I, 2'deoxy A-1); 5'-R(*CP*GP*GP*UP*GP*AP*IP*AP*AP*GP*GP*G)-3' 2bcz C 17 2.4 URS000080DEF8_32630 16411744 32630 ggcagagaaacacacga ................. ................. Crystal Structure of a minimal, mutant all-RNA hairpin ribozyme (U39C, G8I, 2'deoxy A-1); 5'-R(*GP*GP*CP*AP*GP*AP*GP*AP*AP*AP*CP*AP*CP*AP*CP*GP*A)-3' 2bcz D 19 2.4 URS000080E34C_32630 16411744 32630 ucgugguacauuaccugcc ................... ................... Crystal Structure of a minimal, mutant all-RNA hairpin ribozyme (U39C, G8I, 2'deoxy A-1); 5'-R(*UP*CP*GP*UP*GP*GP*UP*AP*CP*AP*UP*UP*AP*CP*CP*UP*GP*CP*C)-3' 2be0 A 21 2.63 URS000080E2C5_32630 15593140 32630 gcgucacaccggugaagucgc ..................... ..................... Complex Between Paromomycin Derivative JS5-39 and the 16S-Rrna A-Site.; 5'-R(*CP*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*C)-3' 2be0 B 21 2.63 URS000080E2C5_32630 15593140 32630 gcgucacaccggugaagucgc ..................... ..................... Complex Between Paromomycin Derivative JS5-39 and the 16S-Rrna A-Site.; 5'-R(*CP*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*C)-3' 2bee A 21 2.6 URS000080E2C5_32630 15593140 32630 gcgucacaccggugaagucgc ..................... ..................... Complex Between Paromomycin derivative JS4 and the 16S-Rrna A Site; 5'-R(*CP*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*C)-3' 2bee B 21 2.6 URS000080E2C5_32630 15593140 32630 gcgucacaccggugaagucgc ..................... ..................... Complex Between Paromomycin derivative JS4 and the 16S-Rrna A Site; 5'-R(*CP*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*C)-3' 2bj2 A 21 NA URS000080DDBD_32630 9739090 32630 ggcaacggaugguucguugcc <<<<<<<.......>>>>>>> (((((((.......))))))) RNA LOOP-LOOP COMPLEX: THE COLE1 INVERTED LOOP SEQUENCE, NMR, MINIMIZED AVERAGE STRUCTURE; RNA (5'-R(*GP*GP*CP*AP*AP*CP*GP*GP*AP*UP*GP*GP*UP*UP*CP*GP*UP*UP*GP*CP*C)-3') 2bj2 B 19 NA URS000080E325_32630 9739090 32630 gcaccgaaccauccggugc <<<<<<.......>>>>>> ((((((.......)))))) RNA LOOP-LOOP COMPLEX: THE COLE1 INVERTED LOOP SEQUENCE, NMR, MINIMIZED AVERAGE STRUCTURE; RNA (5'-R(*GP*CP*AP*CP*CP*GP*AP*AP*CP*CP*AP*UP*CP*CP*GP*GP*UP*GP*C)-3') 2bny S 13 3.0 URS000080DDB6_12022 16531233 12022 ugaggauuaccca <<.<<....>>>> ((.((....)))) MS2 (N87A mutant) - RNA hairpin complex; 5'-R(*AP*CP*AP*UP*GP*AP*GP*GP*AP*UP *UP*AP*CP*CP*CP*AP*UP*GP*U)-3' 2bq5 S 17 2.91 URS000080DDB6_12022 16531233 12022 caugaggauuacccaug <<<<.<<....>>>>>> (.((.((....)))).) MS2 (N87AE89K mutant) - RNA hairpin complex; 5'-R(*AP*CP*AP*UP*GP*AP*GP*GP*AP*UP *UP*AP*CP*CP*CP*AP*UP*GP*U)-3' 2bs1 S 11 2.8 URS000080DDA5_12022 16531233 12022 ugucuaagaca <<<<...>>>> ((((...)))) MS2 (N87AE89K mutant) - Qbeta RNA hairpin complex; 5'-R(*AP*CP*AP*UP*GP*AP*GP*GP*AP*UP *UP*AP*CP*CP*CP*AP*UP*GP*U)-3' 2bu1 S 17 2.2 URS000080DDB6_12022 11720290 12022 caugaggaunacccaug <<<<.<<....>>>>>> ((((.((....)))))) MS2-RNA HAIRPIN (5BRU -5) COMPLEX; 5'-R(*AP*CP*AP*UP*GP*AP*GP*GP*AP*UP *5BU*AP*CP*CP*CP*AP*UP*GP*U)-3' 2c4q S 17 2.38 URS000080DDB6_12022 11720290 12022 caugaggaunacccaug <<<<.<<....>>>>>> ((((.((....)))))) MS2-RNA HAIRPIN (2ONE -5) COMPLEX; 5'-R(*AP*CP*AP*UP*GP*AP*GP*GP*AP*UP *PYO*AP*CP*CP*CP*AP*UP*GP*U)-3' 2c4y S 13 2.68 URS000080DDB6_12022 11720290 12022 ugaggaunaccca <<.<<....>>>> ((.((....)))) MS2-RNA HAIRPIN (2THIOURACIL-5) COMPLEX; 5'-R(*AP*CP*AP*UP*GP*AP*GP*GP*AP*UP *SUR*AP*CP*CP*CP*AP*UP*GP*U)-3' 2c4z S 13 2.6 URS000080DDB6_12022 11720290 12022 ugaggannaccca <<.<<....>>>> ((.((....)))) MS2-RNA HAIRPIN (2SU -5-6) COMPLEX; 5'-R(*AP*CP*AP*UP*GP*AP*GP*GP*AP*SUR *SUR*AP*CP*CP*CP*AP*UP*GP*U)-3' 2c50 S 13 2.65 URS000080E1EC_12022 11720290 12022 ugaggauaaccca <<.<<....>>>> ((.((....)))) MS2-RNA HAIRPIN (A -5) COMPLEX; 5'-R(*AP*CP*AP*UP*GP*AP*GP*GP*AP*UP *AP*AP*CP*CP*CP*AP*UP*GP*U)-3' 2c51 S 13 2.8 URS000080E255_12022 11720290 12022 ugaggaugaccca <<.<<....>>>> ((.((....)))) MS2-RNA HAIRPIN (G -5) COMPLEX; 5'-R(*AP*CP*AP*UP*GP*AP*GP*GP*AP*UP *GP*AP*CP*CP*CP*AP*UP*GP*U)-3' 2d17 A 16 NA URS000080DF82_32630 16272570 32630 cggcaagaggcgaccc ................ ................ Solution RNA structure of stem-bulge-stem region of the HIV-1 dimerization initiation site; 5'-R(*CP*GP*GP*CP*AP*AP*GP*AP*GP*GP*CP*GP*AP*CP*CP*C)-3' 2d17 B 14 NA URS000080E0B5_32630 16272570 32630 gggucggcuugcug .............. .............. Solution RNA structure of stem-bulge-stem region of the HIV-1 dimerization initiation site; 5'-R(*GP*GP*GP*UP*CP*GP*GP*CP*UP*UP*GP*CP*UP*G)-3' 2d18 A 17 NA URS000080E35C_32630 16272570 32630 gcugaagugcacacggc ................. ................. Solution RNA structure of loop region of the HIV-1 dimerization initiation site in the extended-duplex dimer; 5'-R(*GP*CP*UP*GP*AP*AP*GP*UP*GP*CP*AP*CP*AP*CP*GP*GP*C)-3' 2d18 B 17 NA URS000080E35C_32630 16272570 32630 gcugaagugcacacggc ................. ................. Solution RNA structure of loop region of the HIV-1 dimerization initiation site in the extended-duplex dimer; 5'-R(*GP*CP*UP*GP*AP*AP*GP*UP*GP*CP*AP*CP*AP*CP*GP*GP*C)-3' 2d19 A 17 NA URS000080E35C_32630 16272570 32630 gcugaagugcacacggc <<<<.........>>>> ((((.........)))) Solution RNA structure of loop region of the HIV-1 dimerization initiation site in the kissing-loop dimer; 5'-R(*GP*CP*UP*GP*AP*AP*GP*UP*GP*CP*AP*CP*AP*CP*GP*GP*C)-3' 2d19 B 17 NA URS000080E35C_32630 16272570 32630 gcugaagugcacacggc <<<<.........>>>> ((((.........)))) Solution RNA structure of loop region of the HIV-1 dimerization initiation site in the kissing-loop dimer; 5'-R(*GP*CP*UP*GP*AP*AP*GP*UP*GP*CP*AP*CP*AP*CP*GP*GP*C)-3' 2d1a A 39 NA RF00175 URS000080DE22_11676 16272570 0019074 11676 gggucggcuugcugaagugcacacggcaagaggcgaccc ....................................... ....................................... Solution RNA structure model of the HIV-1 dimerization initiation site in the extended-duplex dimer; RNA 2d1a B 39 NA RF00175 URS000080DE22_11676 16272570 0019074 11676 gggucggcuugcugaagugcacacggcaagaggcgaccc ....................................... ....................................... Solution RNA structure model of the HIV-1 dimerization initiation site in the extended-duplex dimer; RNA 2d1b A 39 NA RF00175 URS000080DE22_11676 16272570 0019074 11676 gggucggcuugcugaagugcacacggcaagaggcgaccc <<<<<<.<<<<<<<.........>>>>>>>...>>>>>> ((((((.(((((((.........)))))))...)))))) Solution RNA structure model of the HIV-1 dimerization initiation site in the kissing-loop dimer; RNA 2d1b B 39 NA RF00175 URS000080DE22_11676 16272570 0019074 11676 gggucggcuugcugaagugcacacggcaagaggcgaccc <<<<<<.<<<<<<...........>>>>>>...>>>>>> ((((((.(((((((.........)))))))...)))))) Solution RNA structure model of the HIV-1 dimerization initiation site in the kissing-loop dimer; RNA 2d2k A 13 2.65 URS000080E09E_32630 16262240,12499551 32630 ucccnguccaccg ............. ............. Crystal Structure of a minimal, native (U39) all-RNA hairpin ribozyme; 5'-R(*UP*CP*CP*CP*(A2M)P*GP*UP*CP*CP*AP*CP*CP*G)-3' 2d2k B 12 2.65 URS000080DF3F_32630 16262240,12499551 32630 cggugagaaggg ............ ............ Crystal Structure of a minimal, native (U39) all-RNA hairpin ribozyme; 5'-R(*CP*GP*GP*UP*GP*AP*GP*AP*AP*GP*GP*G)-3' 2d2k C 17 2.65 URS000080DEF8_32630 16262240,12499551 32630 ggcagagaaacacacga ................. ................. Crystal Structure of a minimal, native (U39) all-RNA hairpin ribozyme; 5'-R(*GP*GP*CP*AP*GP*AP*GP*AP*AP*AP*CP*AP*CP*AP*CP*GP*A)-3' 2d2k D 19 2.65 URS000080E37A_32630 16262240,12499551 32630 ucgugguauauuaccugcc ................... ................... Crystal Structure of a minimal, native (U39) all-RNA hairpin ribozyme; 5'-R(*UP*CP*GP*UP*GP*GP*UP*AP*UP*AP*UP*UP*AP*CP*CP*UP*GP*CP*C)-3' 2d2l A 13 2.5 URS000080E09E_32630 16262240,12499551 32630 ucccnguccaccg ............. ............. Crystal Structure of a minimal, all-RNA hairpin ribozyme with a propyl linker (C3) at position U39; 5'-R(*UP*CP*CP*CP*(A2M)P*GP*UP*CP*CP*AP*CP*CP*G)-3' 2d2l B 12 2.5 URS000080DF3F_32630 16262240,12499551 32630 cggugagaaggg ............ ............ Crystal Structure of a minimal, all-RNA hairpin ribozyme with a propyl linker (C3) at position U39; 5'-R(*CP*GP*GP*UP*GP*AP*GP*AP*AP*GP*GP*G)-3' 2d2l C 17 2.5 URS000080DEF8_32630 16262240,12499551 32630 ggcagagaaacacacga ................. ................. Crystal Structure of a minimal, all-RNA hairpin ribozyme with a propyl linker (C3) at position U39; 5'-R(*GP*GP*CP*AP*GP*AP*GP*AP*AP*AP*CP*AP*CP*AP*CP*GP*A)-3' 2d2l D 19 2.5 URS00023358FF_32630 16262240,12499551 32630 ucgugguanauuaccugcc ................... .................. Crystal Structure of a minimal, all-RNA hairpin ribozyme with a propyl linker (C3) at position U39; 5'-R(*UP*CP*GP*UP*GP*GP*UP*AP*(P1P)P*AP*UP*UP*AP*CP*CP*UP*GP*CP*C)-3' 2dd1 A 10 NA URS000080DE92_32630 16734425 32630 gguggaggcu .......... .......... Three consecutive sheared GA pairs in 5'GGUGGAGGCU/3'PCCAAAGCCG; 5'-R(*GP*GP*UP*GP*GP*AP*GP*GP*CP*U)-3' 2dd1 B 10 NA URS000080DF31_32630 16734425 32630 gccgaaaccn .......... .......... Three consecutive sheared GA pairs in 5'GGUGGAGGCU/3'PCCAAAGCCG; 5'-R(*GP*CP*CP*GP*AP*AP*AP*CP*CP*(P5P))-3' 2dd2 A 10 NA URS000080E023_32630 16734425 32630 ggugaaggcu .......... .......... An alternating sheared AA pair in 5'GGUGAAGGCU/3'PCCGAAGCCG: I. The major conformation with A6/A15/A16 stack; 5'-R(*GP*GP*UP*GP*AP*AP*GP*GP*CP*U)-3' 2dd2 B 10 NA URS000080E10B_32630 16734425 32630 gccgaagccn .......... .......... An alternating sheared AA pair in 5'GGUGAAGGCU/3'PCCGAAGCCG: I. The major conformation with A6/A15/A16 stack; 5'-R(*GP*CP*CP*GP*AP*AP*GP*CP*CP*(P5P))-3' 2dd3 A 10 NA URS000080E023_32630 16734425 32630 ggugaaggcu .......... .......... An alternating sheared AA pair in 5'GGUGAAGGCU/3'PCCGAAGCCG: II. The minor conformation with A6/A5/A16 stack; 5'-R(*GP*GP*UP*GP*AP*AP*GP*GP*CP*U)-3' 2dd3 B 10 NA URS000080E10B_32630 16734425 32630 gccgaagccn .......... .......... An alternating sheared AA pair in 5'GGUGAAGGCU/3'PCCGAAGCCG: II. The minor conformation with A6/A5/A16 stack; 5'-R(*GP*CP*CP*GP*AP*AP*GP*CP*CP*(P5P))-3' 2e5l A 1517 3.3 RF00177,RF01959,RF01960 URS000080E378_274 17355865 0003735 0005840 274 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucaccuccuuuc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<.......>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<<....>>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.....)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(.(((....)))..))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((...(((((((....((........)).......)))))))...).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((((..(((((((....)))))))...((((....))))..))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..((...(((.....))).))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.............. A snapshot of the 30S ribosomal subunit capturing mRNA via the Shine- Dalgarno interaction; 16S ribosomal RNA 2esi A 23 3.0 URS000080E29E_32630 16214802 32630 uugcgucacaccggugaagucgc ....................... ....................... Complex between Kanamycin A and the 16S-Rrna A Site.; 5'-R(*UP*UP*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*C)-3' 2esi B 21 3.0 URS000080E29E_32630 16214802 32630 gcgucacaccggugaagucgc ..................... ..................... Complex between Kanamycin A and the 16S-Rrna A Site.; 5'-R(*UP*UP*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*C)-3' 2esj A 21 2.2 URS000080E2C5_32630 16214802 32630 gcgucacaccggugaagucgc ..................... ..................... Complex between Lividomycin A and the 16S-Rrna A Site; 5'-R(*CP*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*C)-3' 2esj B 21 2.2 URS000080E2C5_32630 16214802 32630 gcgucacaccggugaagucgc ..................... ..................... Complex between Lividomycin A and the 16S-Rrna A Site; 5'-R(*CP*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*C)-3' 2et3 A 21 2.8 URS000080E2C5_32630 16214802 32630 gcgucacaccggugaagucgc ..................... ..................... Complex Between Gentamicin C1A and the 16S-RRNA A-Site; 5'-R(*CP*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*C)-3' 2et3 B 21 2.8 URS000080E2C5_32630 16214802 32630 gcgucacaccggugaagucgc ..................... ..................... Complex Between Gentamicin C1A and the 16S-RRNA A-Site; 5'-R(*CP*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*C)-3' 2et4 A 21 2.4 URS000080E2C5_32630 16214802 32630 gcgucacaccggugaagucgc ..................... ..................... Complex Between Neomycin B and the 16S-RRNA A-Site; 5'-R(*CP*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*C)-3' 2et4 B 21 2.4 URS000080E2C5_32630 16214802 32630 gcgucacaccggugaagucgc ..................... ..................... Complex Between Neomycin B and the 16S-RRNA A-Site; 5'-R(*CP*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*C)-3' 2et5 A 21 2.2 URS000080E2C5_32630 16214802 32630 gcgucacaccggugaagucgc ..................... ..................... Complex Between Ribostamycin and the 16S-RRNA A-Site; 5'-R(*CP*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*C)-3' 2et5 B 21 2.2 URS000080E2C5_32630 16214802 32630 gcgucacaccggugaagucgc ..................... ..................... Complex Between Ribostamycin and the 16S-RRNA A-Site; 5'-R(*CP*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*C)-3' 2et8 A 21 2.5 URS000080E2C5_32630 16214802 32630 gcgucacaccggugaagucgc ..................... ..................... Complex Between Neamine and the 16S-RRNA A-Site; 5'-R(*CP*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*C)-3' 2et8 B 21 2.5 URS000080E2C5_32630 16214802 32630 gcgucacaccggugaagucgc ..................... ..................... Complex Between Neamine and the 16S-RRNA A-Site; 5'-R(*CP*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*C)-3' 2ez6 C 28 2.05 URS000080DE20_32630 16439209 32630 aaaggucauucgcaagaguggccuuuau <<<<<<<<<<<....>>>>>>>>>>>.. (((((((((((....))))))))))).. Crystal structure of Aquifex aeolicus RNase III (D44N) complexed with product of double-stranded RNA processing; 28-MER 2ez6 D 28 2.05 URS000080DE20_32630 16439209 32630 aaaggucauucgcaagaguggccuuuau <<<<<<<<<<<....>>>>>>>>>>>.. (((((((((((....))))))))))).. Crystal structure of Aquifex aeolicus RNase III (D44N) complexed with product of double-stranded RNA processing; 28-MER 2f4s A 21 2.8 URS000080DF2F_32630 16492561 32630 gcgucacaccggugaagucgc ..................... ..................... A-site RNA in complex with neamine; 5'-R(P*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*C)-3' 2f4s B 21 2.8 URS000080DF2F_32630 16492561 32630 gcgucacaccggugaagucgc ..................... ..................... A-site RNA in complex with neamine; 5'-R(P*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*C)-3' 2f4t A 21 3.0 URS000080DF2F_32630 16492561 32630 gcgucacaccggugaagucgc ..................... ..................... Asite RNA + designer antibiotic; 5'-R(*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*C)-3' 2f4t B 23 3.0 URS000080E29E_32630 16492561 32630 uugcgucacaccggugaagucgc ....................... ....................... Asite RNA + designer antibiotic; 5'-R(*UP*UP*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*C)-3' 2f4u A 21 2.6 URS000080DF2F_32630 16492561 32630 gcgucacaccggugaagucgc ..................... ..................... Asite RNA + designer antibiotic; 5'-R(*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*C)-3' 2f4u B 21 2.6 URS000080DF2F_32630 16492561 32630 gcgucacaccggugaagucgc ..................... ..................... Asite RNA + designer antibiotic; 5'-R(*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*C)-3' 2f4v A 1507 3.8 RF00177,RF01959,RF01960 URS000080E34A_274 16492561 0003735 0005840 274 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggauca ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<<<<<<<<.......>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<.<......<<........>>..........<<<<<<<.......<<...<...<<<<<<<....>>>>>>>....<<.......>>...>...>>..<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<...<<<.....>>>.>.....>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>..>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.....)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...((.((....)).).))))).)).))))))..((((.......(((....)))......))))....(.(((...(....((((.....)))).....)....))).)......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((.(((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..)))))..))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........((((((...(...((............(.(....).)........(((....).))........))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((.(...(...((.......)).)....).)))))..(..(((((....))))).....)..)))).....).).)))...)).))))).....))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((...((((.(((..((.(((.((((((...(.((((....(((....))).)))).)..)))))).))).))..))).))))....))...)..)..(((((((((....)))))))))}..... 30S ribosome + designer antibiotic; 16S ribosomal RNA 2f4x A 24 NA URS000080E05B_32630 16410614 32630 gguugcugaagcgcgcacggcaac .<<<<<<...........>>>>>> .(((((((.........))))))) NMR Solution of HIV-1 Lai Kissing Complex; 5'-R(P*GP*GP*UP*UP*GP*CP*UP*GP*AP*AP*GP*CP*GP*CP*GP*CP*AP*CP*GP*GP*CP*AP*AP*C)-3' 2f4x B 24 NA URS000080E05B_32630 16410614 32630 gguugcugaagcgcgcacggcaac .<<<<<<...........>>>>>> .(((((((.........))))))) NMR Solution of HIV-1 Lai Kissing Complex; 5'-R(P*GP*GP*UP*UP*GP*CP*UP*GP*AP*AP*GP*CP*GP*CP*GP*CP*AP*CP*GP*GP*CP*AP*AP*C)-3' 2f8s C 22 3.0 URS000080DE2C_32630 17027504 32630 agacagcauauaugcugucuuu ...................... ...................... Crystal structure of Aa-Ago with externally-bound siRNA; 5'-R(P*AP*GP*AP*CP*AP*GP*CP*AP*UP*AP*UP*AP*UP*GP*CP*UP*GP*UP*CP*UP*UP*U)-3' 2f8s D 22 3.0 URS000080DE2C_32630 17027504 32630 agacagcauauaugcugucuuu ...................... ...................... Crystal structure of Aa-Ago with externally-bound siRNA; 5'-R(P*AP*GP*AP*CP*AP*GP*CP*AP*UP*AP*UP*AP*UP*GP*CP*UP*GP*UP*CP*UP*UP*U)-3' 2f8t C 26 3.1 URS000080DF6A_32630 17027504 32630 agacagcaugcaugcaugcugucuuu .......................... .......................... Crystal structure of Aa-Ago with externally-bound siRNA; 26-MER 2f8t D 24 3.1 URS000080DF6A_32630 17027504 32630 agacagcaugcaugcaugcugucu ........................ ........................ Crystal structure of Aa-Ago with externally-bound siRNA; 26-MER 2fcx A 23 2.0 URS000080E167_32630 16679451 32630 cungcugaagugcacacagcaag <<<<<<<.........>>>>>>> (((((((.........))))))) HIV-1 DIS kissing-loop in complex with neamine; HIV-1 DIS RNA 2fcx B 23 2.0 URS000080E167_32630 16679451 32630 cungcugaagugcacacagcaag <<<<<<<.........>>>>>>> (((((((.........))))))) HIV-1 DIS kissing-loop in complex with neamine; HIV-1 DIS RNA 2fcy A 23 2.2 URS000080E167_32630 16679451 32630 cungcugaagugcacacagcaag <<<<<<<.........>>>>>>> (((((((.........))))))) HIV-1 DIS kissing-loop in complex with Neomycin; HIV-1 DIS RNA 2fcy B 23 2.2 URS000080E167_32630 16679451 32630 cungcugaagugcacacagcaag <<<<<<<.........>>>>>>> (((((((.........))))))) HIV-1 DIS kissing-loop in complex with Neomycin; HIV-1 DIS RNA 2fcz A 23 2.01 URS000080E167_32630 16679451 32630 cungcugaagugcacacagcaag <<<<<<<.........>>>>>>> (((((((.........))))))) HIV-1 DIS kissing-loop in complex with ribostamycin; HIV-1 DIS RNA 2fcz B 23 2.01 URS000080E167_32630 16679451 32630 cungcugaagugcacacagcaag <<<<<<<.........>>>>>>> (((((((.........))))))) HIV-1 DIS kissing-loop in complex with ribostamycin; HIV-1 DIS RNA 2fcz C 23 2.01 URS000080E167_32630 16679451 32630 cungcugaagugcacacagcaag <<<<<<<.........>>>>>>> (((((((.........))))))) HIV-1 DIS kissing-loop in complex with ribostamycin; HIV-1 DIS RNA 2fcz D 23 2.01 URS000080E167_32630 16679451 32630 cungcugaagugcacacagcaag <<<<<<<.........>>>>>>> (((((((.........))))))) HIV-1 DIS kissing-loop in complex with ribostamycin; HIV-1 DIS RNA 2fd0 A 23 1.8 URS000080E167_32630 16679451 32630 cungcugaagugcacacagcaag <<<<<<<.........>>>>>>> (((((((.........))))))) HIV-1 DIS kissing-loop in complex with lividomycin; HIV-1 DIS RNA 2fd0 B 23 1.8 URS000080E167_32630 16679451 32630 cungcugaagugcacacagcaag <<<<<<<.........>>>>>>> (((((((.........))))))) HIV-1 DIS kissing-loop in complex with lividomycin; HIV-1 DIS RNA 2fgp A 13 2.4 URS000080E09E_32630 16411744 32630 ucccaguccaccg ............. ............. Crystal structure of a minimal, all RNA hairpin ribozyme with modifications (g8dap, u39c) at ph 8.6; 5'-R(*UP*CP*CP*CP*AP*GP*UP*CP*CP*AP*CP*CP*G)-3' 2fgp B 12 2.4 URS000080DF3F_32630 16411744 32630 cgguganaaggg ............ ............ Crystal structure of a minimal, all RNA hairpin ribozyme with modifications (g8dap, u39c) at ph 8.6; 5'-R(*CP*GP*GP*UP*GP*AP*(N6G)P*AP*AP*GP*GP*G)-3' 2fgp C 17 2.4 URS000080DEF8_32630 16411744 32630 ggcagagaaacacacga ................. ................. Crystal structure of a minimal, all RNA hairpin ribozyme with modifications (g8dap, u39c) at ph 8.6; 5'-R(*GP*GP*CP*AP*GP*AP*GP*AP*AP*AP*CP*AP*CP*AP*CP*GP*A)-3' 2fgp D 19 2.4 URS000080E34C_32630 16411744 32630 ucgugguacauuaccugcc ................... ................... Crystal structure of a minimal, all RNA hairpin ribozyme with modifications (g8dap, u39c) at ph 8.6; 5'-R(*UP*CP*GP*UP*GP*GP*UP*AP*CP*AP*UP*UP*AP*CP*CP*UP*GP*CP*C) -3' 2fqn A 22 2.3 URS000080DDFE_32630 16452297 32630 ugcgucgcuccggaaaagucgc ...................... ...................... Crystal structure of the Homo sapiens cytoplasmic ribosomal decoding A site; 5'-R(*UP*UP*GP*CP*GP*UP*CP*GP*CP*UP*CP*CP*GP*GP*AP*AP*AP*AP*GP*UP*CP*GP*C)-3' 2fqn B 21 2.3 URS000080DDFE_32630 16452297 32630 gcgucgcuccggaaaagucgc ..................... ..................... Crystal structure of the Homo sapiens cytoplasmic ribosomal decoding A site; 5'-R(*UP*UP*GP*CP*GP*UP*CP*GP*CP*UP*CP*CP*GP*GP*AP*AP*AP*AP*GP*UP*CP*GP*C)-3' 2g5k A 22 2.8 URS000080DDFE_32630 16596680 32630 ugcgucgcuccggaaaagucgc ...................... ...................... Crystal Structure of the Homo sapiens Cytoplasmic Ribosomal Decoding Site complexed with Apramycin; 5'-R(*UP*UP*GP*CP*GP*UP*CP*GP*CP*UP*CP*CP*GP*GP*AP*AP*AP*AP*GP*UP*CP*GP*C)-3' 2g5k B 22 2.8 URS000080DDFE_32630 16596680 32630 ugcgucgcuccggaaaagucgc ...................... ...................... Crystal Structure of the Homo sapiens Cytoplasmic Ribosomal Decoding Site complexed with Apramycin; 5'-R(*UP*UP*GP*CP*GP*UP*CP*GP*CP*UP*CP*CP*GP*GP*AP*AP*AP*AP*GP*UP*CP*GP*C)-3' 2g92 A 12 1.61 URS000080E206_32630 17163665 32630 cgcnaauuagcg ............ ............ Crystal Structure Analysis of the RNA Dodecamer CGC-(NF2)-AAUUAGCG, with an Incorporated 2,4-Difluorotoluyl Residue (NF2); 5'-R(*CP*GP*CP*(NF2)P*AP*AP*UP*UP*AP*GP*CP*G)-3' 2g92 B 12 1.61 URS000080E206_32630 17163665 32630 cgcnaauuagcg ............ ............ Crystal Structure Analysis of the RNA Dodecamer CGC-(NF2)-AAUUAGCG, with an Incorporated 2,4-Difluorotoluyl Residue (NF2); 5'-R(*CP*GP*CP*(NF2)P*AP*AP*UP*UP*AP*GP*CP*G)-3' 2gcs A 21 2.1 URS000080E25E_119072 16990543 119072 ngcgccuggacuuaaagccau ..................... ..................... Pre-cleavage state of the Thermoanaerobacter tengcongensis glmS ribozyme; glmS ribozyme amino RNA inhibitor 2gcs B 123 2.1 RF00234 URS000080DF18_119072 16990543 0003824 0010468 119072 ggcuuuaaguugacgagggcaggguuuaucgagacaucggcgggugcccugcggucuuccugcgaccguuagaggacugguaaaaccacaggcgacuguggcauagagcaguccgggcaggan .............(((...<<<<<<...)))..............>>>>>>(((((.<<<<<<))))).....<<<<<<......<<<<<<....>>>>>>.......>>>>>>..>>>>>>. .............[[[...((((((...]]]..............))))))[[[[[.((((((]]]]].....((((((......((((((....)))))).......))))))..)))))). Pre-cleavage state of the Thermoanaerobacter tengcongensis glmS ribozyme; glmS ribozyme RNA 2gcv A 20 2.1 URS000080E25B_119072 16990543 119072 gcgccuggacuuaaagccau .................... .................... Post-cleavage state of the Thermoanaerobacter tengcongensis glmS ribozyme; glmS ribozyme product oligonucleotide 2gcv B 123 2.1 RF00234 URS000080DF18_119072 16990543 0003824 0010468 119072 ggcuuuaaguugacgagggcaggguuuaucgagacaucggcgggugcccugcggucuuccugcgaccguuagaggacugguaaaaccacaggcgacuguggcauagagcaguccgggcaggan .............(((...<<<<<<...)))..............>>>>>>(((((.<<<<<<))))).....<<<<<<......<<<<<<....>>>>>>.......>>>>>>..>>>>>>. .............[[[...((((((...]]]..............))))))[[[[[.((((((]]]]].....((((((......((((((....)))))).......))))))..)))))). Post-cleavage state of the Thermoanaerobacter tengcongensis glmS ribozyme; glmS ribozyme RNA 2gic R 45 2.92 URS000080E17E_32630 16778022 32630 uuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuu ............................................. ............................................. Crystal Structure of a vesicular stomatitis virus nucleocapsid-RNA complex; 45-MER 2gje R 13 3.37 URS000080DE5E_32630 16923390 32630 uaaauaaccugua ............. ............. Structure of a guideRNA-binding protein complex bound to a gRNA; guide RNA 40-mer 2gjw E 18 2.85 URS000080E337_32630 16690865 32630 gcgaccgaccauagcugc .................. .................. RNA Recognition and Cleavage by an Splicing Endonuclease; 5'-R(*GP*CP*GP*AP*CP*CP*GP*AP*CP*CP*AP*(DU)P*AP*GP*CP*UP*GP*CP*A)-3' 2gjw F 12 2.85 URS000080E0F0_32630 16690865 32630 ugcagcggucan ............ ............ RNA Recognition and Cleavage by an Splicing Endonuclease; 5'-R(*UP*GP*CP*AP*GP*CP*GP*GP*UP*CP*AP*(A23))-3' 2gjw I 19 2.85 URS000080E337_32630 16690865 32630 gcgaccgaccauagcugca ................... ................... RNA Recognition and Cleavage by an Splicing Endonuclease; 5'-R(*GP*CP*GP*AP*CP*CP*GP*AP*CP*CP*AP*(DU)P*AP*GP*CP*UP*GP*CP*A)-3' 2gjw J 12 2.85 URS000080E0F0_32630 16690865 32630 ugcagcggucan ............ ............ RNA Recognition and Cleavage by an Splicing Endonuclease; 5'-R(*UP*GP*CP*AP*GP*CP*GP*GP*UP*CP*AP*(A23))-3' 2gm0 A 35 NA RF00175 URS000080DE12_11676 16603544 0019074 11676 gacggcuugcugaagcgcgcacggcaagaggcguc ................................... ................................... Linear dimer of stemloop SL1 from HIV-1; RNA (35-MER) 2gm0 B 35 NA RF00175 URS000080DE12_11676 16603544 0019074 11676 gacggcuugcugaagcgcgcacggcaagaggcguc ................................... ................................... Linear dimer of stemloop SL1 from HIV-1; RNA (35-MER) 2h0s A 22 2.35 URS000080DE3A_119072 16990543 119072 aagcgccuggacuuaaagccau ...................... ...................... Pre-cleavage state of the Thermoanaerobacter tengcongensis glmS ribozyme; glmS ribozyme deoxy RNA inhibitor 2h0s B 123 2.35 RF00234 URS000080DF18_119072 16990543 0003824 0010468 119072 ggcuuuaaguugacgagggcaggguuuaucgagacaucggcgggugcccugcggucuuccugcgaccguuagaggacugguaaaaccacaggcgacuguggcauagagcaguccgggcaggan .............(((...<<<<<<...)))..............>>>>>>(((((.<<<<<<))))).....<<<<<<......<<<<<<....>>>>>>.......>>>>>>..>>>>>>. .............[[[...((((((...]]]..............))))))[[[[[.((((((]]]]].....((((((......((((((....)))))).......))))))..)))))). Pre-cleavage state of the Thermoanaerobacter tengcongensis glmS ribozyme; glmS ribozyme RNA 2h0w A 20 2.4 URS000080E25B_119072 16990543 119072 gcgccuggacuuaaagccau .................... .................... Post-cleavage state of the Thermoanaerobacter tengcongensis glmS ribozyme; glmS ribozyme product oligonucleotide 2h0w B 123 2.4 RF00234 URS000080DF18_119072 16990543 0003824 0010468 119072 ggcuuuaaguugacgagggcaggguuuaucgagacaucggcgggugcccugcggucuuccugcgaccguuagaggacugguaaaaccacaggcgacuguggcauagagcaguccgggcaggan .............(((...<<<<<<...)))..............>>>>>>(((((.<<<<<<))))).....<<<<<<......<<<<<<....>>>>>>.......>>>>>>..>>>>>>. .............[[[...((((((...]]]..............))))))[[[[[.((((((]]]]].....((((((......((((((....)))))).......))))))..)))))). Post-cleavage state of the Thermoanaerobacter tengcongensis glmS ribozyme; glmS ribozyme RNA 2h0x A 21 2.3 URS000080E25E_119072 16990543 119072 ngcgccuggacuuaaagccau ..................... ..................... Pre-cleavage state of the Thermoanaerobacter tengcongensis glmS ribozyme; glmS ribozyme amino RNA inhibitor 2h0x B 123 2.3 RF00234 URS000080DF18_119072 16990543 0003824 0010468 119072 ggcuuuaaguugacgagggcaggguuuaucgagacaucggcgggugcccugcggucuuccugcgaccguuagaggacugguaaaaccacaggcgacuguggcauagagcaguccgggcaggan .............(((...<<<<<<...)))..............>>>>>>(((((.<<<<<<))))).....<<<<<<......<<<<<<....>>>>>>.......>>>>>>..>>>>>>. .............[[[...((((((...]]]..............))))))[[[[[.((((((]]]]].....((((((......((((((....)))))).......))))))..)))))). Pre-cleavage state of the Thermoanaerobacter tengcongensis glmS ribozyme; glmS ribozyme RNA 2h0z A 21 2.7 URS000080E125_119072 16990543 119072 agcgccuggacuuaaagccau ..................... ..................... Pre-cleavage state of the Thermoanaerobacter tengcongensis glmS ribozyme bound to glucose-6-phosphate; glmS ribozyme deoxy RNA inhibitor 2h0z B 123 2.7 RF00234 URS000080DF18_119072 16990543 0003824 0010468 119072 ggcuuuaaguugacgagggcaggguuuaucgagacaucggcgggugcccugcggucuuccugcgaccguuagaggacugguaaaaccacaggcgacuguggcauagagcaguccgggcaggaa .............(((...<<<<<<...)))..............>>>>>>(((((.<<<<<<))))).....<<<<<<......<<<<<<....>>>>>>.......>>>>>>..>>>>>>. .............[[[...((((((...]]]..............))))))[[[[[.((((((]]]]].....((((((......((((((....)))))).......))))))..)))))). Pre-cleavage state of the Thermoanaerobacter tengcongensis glmS ribozyme bound to glucose-6-phosphate; glmS ribozyme RNA 2h1m A 16 2.9 URS000080DE73_32630 16866550 32630 gcanaguuaaaucugc ................ ................ Synthesis, Oxidation Behavior, Crystallization and Structure of 2'-Methylseleno Guanosine Containing RNAs; 5'-R(*GP*CP*AP*(XUG)P*AP*GP*UP*UP*AP*AP*AP*UP*CP*UP*GP*C)-3' 2h1m B 16 2.9 URS000080DE73_32630 16866550 32630 gcanaguuaaaucugc ................ ................ Synthesis, Oxidation Behavior, Crystallization and Structure of 2'-Methylseleno Guanosine Containing RNAs; 5'-R(*GP*CP*AP*(XUG)P*AP*GP*UP*UP*AP*AP*AP*UP*CP*UP*GP*C)-3' 2ho6 A 20 2.8 URS000080E125_119072 16990543 119072 gcgccuggacuuaaagccau .................... .................... Post-cleavage state of the Thermoanaerobacter tengcongensis glmS ribozyme; glmS ribozyme substrate RNA 2ho6 B 123 2.8 RF00234 URS000080DF18_119072 16990543 0003824 0010468 119072 ggcuuuaaguugacgagggcaggguuuaucgagacaucggcgggugcccugcggucuuccugcgaccguuagaggacugguaaaaccacaggcgacuguggcauagagcaguccgggcaggan .............(((...<<<<<<...)))..............>>>>>>(((((.<<<<<<))))).....<<<<<<......<<<<<<....>>>>>>.......>>>>>>..>>>>>>. .............[[[...((((((...]]]..............))))))[[[[[.((((((]]]]].....((((((......((((((....)))))).......))))))..)))))). Post-cleavage state of the Thermoanaerobacter tengcongensis glmS ribozyme; glmS ribozyme RNA 2ho7 A 21 2.9 URS000080E125_119072 16990543 119072 agcgccuggacuuaaagccau ..................... ..................... Pre-cleavage state of the Thermoanaerobacter tengcongensis glmS ribozyme bound to glucose-6-phosphate; glmS ribozyme substrate RNA 2ho7 B 123 2.9 RF00234 URS000080DF18_119072 16990543 0003824 0010468 119072 ggcuuuaaguugacgagggcaggguuuaucgagacaucggcgggugcccugcggucuuccugcgaccguuagaggacugguaaaaccacaggcgacuguggcauagagcaguccgggcaggan .............(((...<<<<<<...)))..............>>>>>>(((((.<<<<<<))))).....<<<<<<......<<<<<<....>>>>>>.......>>>>>>..>>>>>>. .............[[[...((((((...]]]..............))))))[[[[[.((((((]]]]].....((((((......((((((....)))))).......))))))..)))))). Pre-cleavage state of the Thermoanaerobacter tengcongensis glmS ribozyme bound to glucose-6-phosphate; glmS ribozyme RNA 2i7e A 43 NA URS000080DD2F_32630 17119098 32630 gggauauggaagaaccggggaaacuugguucuuccuaaguccu <<<<<..<<<<<<<<<<<......>>>>>>>>>>>...>>>>> (((((..((((((((((((....))))))))))))...))))) GAAA tetralooop receptor complex with associated cobalt hexammine.; 43-MER 2i7e B 43 NA URS000080DD2F_32630 17119098 32630 gggauauggaagaaccggggaaacuugguucuuccuaaguccu <<<<<..<<<<<<<<<<<......>>>>>>>>>>>...>>>>> ((((...((((((((((((....))))))))))))....)))) GAAA tetralooop receptor complex with associated cobalt hexammine.; 43-MER 2i7z A 43 NA URS000080DD2F_32630 17119098 32630 gggauauggaagaaccggggaaacuugguucuuccuaaguccu <<<<<..<<<<<<<<<<<......>>>>>>>>>>>...>>>>> (((((..((((((((((((....))))))))))))...))))) GAAA tetraloop receptor complex with associated manganese ions.; 43-MER 2i7z B 43 NA URS000080DD2F_32630 17119098 32630 gggauauggaagaaccggggaaacuugguucuuccuaaguccu <<<<<..<<<<<<<<<<<......>>>>>>>>>>>...>>>>> (((((..((((((((((((....))))))))))))...))))) GAAA tetraloop receptor complex with associated manganese ions.; 43-MER 2i91 D 14 2.65 URS000080E00F_32630 17041599 32630 gguaggcuuuucaa .............. .............. 60kDa Ro autoantigen in complex with a fragment of misfolded RNA; 5'-R(*C*GP*GP*UP*AP*GP*GP*CP*UP*UP*UP*UP*CP*AP*A)-3' 2i91 F 15 2.65 URS000080E00F_32630 17041599 32630 cgguaggcuuuucaa ............... ............... 60kDa Ro autoantigen in complex with a fragment of misfolded RNA; 5'-R(*C*GP*GP*UP*AP*GP*GP*CP*UP*UP*UP*UP*CP*AP*A)-3' 2il9 A 135 3.1 RF00458 URS000080DDA6_64698 17124290 0043022 64698 cugacuaugugaucuuauuaaaauuagguuaaacgagguuaaaaauaguuuuaauauugcuauaguagaggucuugcgaaagcuuaccacacaagauggaccggagcgaaagcuccaauaucuaguguacccucg .<...<.......<.<<<<<<<<<<<...................>>>>>>>>>>>..>.....>...><<<<<.<<....>>.....((((.((((>>>>><<<<<....>>>>>...)))).))))....... .............(...(..(((((.....................)))))..)....)..........[[..[..............((...(((.]..]]...((....)).......)))...))....... Crystal Structure of Plautia Stali Intestine Virus Intergenic Region Internal Ribosome Entry Site Ribosomal Binding Domain RNA at 3.1 Angstroms; Ribosomal Binding Domain of the IRES RNA 2il9 M 132 3.1 RF00458 URS000080DDA6_64698 17124290 0043022 64698 cugacuaugugaucuuauuaaaauuagguuaaaucgagguuaaaaauaguuuuaauauugcuaagaggucuugcgaaagcuuaccacacaagauggaccggagcgaaagcuccaauaucuaguguacccucg <<.............<<<<<<<<<<<....................>>>>>>>>>>>........>><<<<.<<....>>.....((((.((((>>>>.<<<<<....>>>>>...)))).))))....... .(.............((.((.(((((....................))))).)).)).......)..((((...................[[[.))))...(((....)))......]]]............ Crystal Structure of Plautia Stali Intestine Virus Intergenic Region Internal Ribosome Entry Site Ribosomal Binding Domain RNA at 3.1 Angstroms; Ribosomal Binding Domain of the IRES RNA 2iz8 S 13 3.3 URS000080DF8F_12022 12060685 12022 ugaggcucaccca <<.<<....>>>> ((.((....)))) MS2-RNA HAIRPIN (C-7) COMPLEX; RNA, (5'-R(*AP*CP*AP*UP*GP*AP*GP*GP*CP*UP*CP* AP*CP*CP*CP*AP*UP*GP*U)-3') 2iz9 S 15 2.85 URS000080DDB6_12022 11095669 12022 augaggaunacccau <<<.<<....>>>>> .((.((....)))). MS2-RNA HAIRPIN (4ONE -5) COMPLEX; 5'-R(*AP*CP*AP*UP*GP*AP*GP*GP*AP*U ONEP *AP*CP*CP*CP*AP*UP*GP*U)-3' 2izm S 13 2.7 URS000080E283_12022 12060685 12022 ugcggaucaccca <<.<<....>>>> ((.((....)))) MS2-RNA HAIRPIN (C-10) COMPLEX; 5'-R(*AP*CP*AP*UP*GP*CP*GP*GP*AP*UP *CP*AP*CP*CP*CP*AP*UP*GP*U)-3' 2izn S 11 2.56 URS000080E328_12022 12060685 12022 cgcgauuacgg <.<<....>>> (.((....))) MS2-RNA HAIRPIN (G-10) COMPLEX; 5'-R(*AP*CP*AP*UP*CP*GP*CP*GP*AP*UP *UP*AP*CP*GP*GP*AP*UP*GP*U)-3' 2j28 A 117 9.5 RF00001 URS000080DF7E_562 17086193 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggc <<<<<<<<<.....<<<<<<<<.....<<<<<<.............>>>>..>>....>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>> (((((((((.....((((((((.....((((((...(.....)...))))..))....)))))).)).((.......((((((((...)))))))).......))...))))))))) MODEL OF E. COLI SRP BOUND TO 70S RNCS; 5S RIBOSOMAL RNA 2j28 B 2841 9.5 RF02540,RF02541 URS00004B0F34_562 17086193 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaacaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauggaaguguggacgccagucugcauggcuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<.......>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.......<<<<<..<<....>>...>>>>>.......>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<.......<<<<<<<....>>>>>>>......>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>.(<<...<<<<<<<...<<<<<<.......>>>>>>.....<<)..(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<<...>>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((...(((((((((.(...(((...(((.((((.......)))).)))..)).)...).)))))).)))...))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((..((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((.....{{{....)))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((((.(...(((((((......)))))))..).)))).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((...))))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). MODEL OF E. COLI SRP BOUND TO 70S RNCS; 23S RIBOSOMAL RNA 2jlt A 18 2.9 URS000080DE2A_562 18996893 562 ggncggucccagacgacc <<<<<........>>>>> (((((........))))) Crystal structure of an RNA kissing complex; R06 2jlt B 16 2.9 URS000080DDA7_562 18996893 562 ggagccugggagcncc <<<<<......>>>>> (((((......))))) Crystal structure of an RNA kissing complex; TAR 2jxq A 10 NA URS000080E386_32630 18399645 32630 gcagagagcg .......... .......... NMR structure of RNA duplex; RNA (5'-R(*GP*CP*AP*GP*AP*GP*AP*GP*CP*G)-3') 2jxq B 10 NA URS000080E009_32630 18399645 32630 cgcucucugc .......... .......... NMR structure of RNA duplex; RNA (5'-R(*CP*GP*CP*UP*CP*UP*CP*UP*GP*C)-3') 2jxs A 11 NA URS000080E286_32630 18399645 32630 gcagaagagcg ........... ........... NMR structure of RNA duplex containing single adenosine bulge; 5'-R(*GP*CP*AP*GP*AP*AP*GP*AP*GP*CP*G)-3' 2jxs B 10 NA URS000080E009_32630 18399645 32630 cgcucucugc .......... .......... NMR structure of RNA duplex containing single adenosine bulge; 5'-R(*CP*GP*CP*UP*CP*UP*CP*UP*GP*C)-3' 2jyf A 43 NA URS000080DD2F_32630 32630 gggauauggaagaaccggggaaacuugguucuuccuaaguccu <<<<<..<<<<<<<<<<<<....>>>>>>>>>>>>...>>>>> (((((..((((((((((((....))))))))))))...))))) Tetraloop-receptor RNA complex; RNA (43-MER) 2jyf B 43 NA URS000080DD2F_32630 32630 gggauauggaagaaccggggaaacuugguucuuccuaaguccu <<<<<..<<<<<<<<<<<<....>>>>>>>>>>>>...>>>>> (((((..((((((((((((....))))))))))))...))))) Tetraloop-receptor RNA complex; RNA (43-MER) 2jyh A 43 NA URS000080DD2F_32630 32630 gggauauggaagaaccggggaaacuugguucuuccuaaguccu <<<<<..<<<<<<<<<<<......>>>>>>>>>>>...>>>>> (((((..((((((((((((....))))))))))))...))))) Rigid-body refinement of the tetraloop-receptor RNA complex; RNA (43-MER) 2jyh B 43 NA URS000080DD2F_32630 32630 gggauauggaagaaccggggaaacuugguucuuccuaaguccu <<<<<..<<<<<<<<<<<......>>>>>>>>>>>...>>>>> (((((..((((((((((((....))))))))))))...))))) Rigid-body refinement of the tetraloop-receptor RNA complex; RNA (43-MER) 2jyj A 43 NA URS000080DD2F_32630 16002091 32630 gggauauggaagaaccggggaaacuugguucuuccuaaguccu <<<<<..<<<<<<<<<<<<....>>>>>>>>>>>>...>>>>> (((((..((((((((((((....))))))))))))...))))) Re-refining the tetraloop-receptor RNA-RNA complex using NMR-derived restraints and Xplor-nih (2.18); RNA (43-MER) 2jyj B 43 NA URS000080DD2F_32630 16002091 32630 gggauauggaagaaccggggaaacuugguucuuccuaaguccu <<<<<..<<<<<<<<<<<<....>>>>>>>>>>>>...>>>>> (((((..((((((((((((....))))))))))))...))))) Re-refining the tetraloop-receptor RNA-RNA complex using NMR-derived restraints and Xplor-nih (2.18); RNA (43-MER) 2k7e A 12 NA URS000080E018_32630 19324888 32630 gcgguguaaaag ............ ............ NMR structure of the human tRNALys3 bound to the HIV genome Loop I; RNA (5'-R(*GP*CP*GP*GP*UP*GP*UP*AP*AP*AP*AP*G)-3') 2k7e B 12 NA URS000080E123_32630 19324888 32630 cunuuaaucugc ............ ............ NMR structure of the human tRNALys3 bound to the HIV genome Loop I; RNA (5'-R(*CP*UP*(SUR)P*UP*UP*AP*AP*(PSU)P*CP*UP*GP*C)-3') 2kbp A 12 NA URS000080E0FC_32630 19183046 32630 uaggguuagggu ............ ............ Solution structure of a G-quadruplex of human telomeric RNA; 5'-R(*UP*AP*GP*GP*GP*UP*UP*AP*GP*GP*GP*U)-3' 2kbp B 12 NA URS000080E0FC_32630 19183046 32630 uaggguuagggu ............ ............ Solution structure of a G-quadruplex of human telomeric RNA; 5'-R(*UP*AP*GP*GP*GP*UP*UP*AP*GP*GP*GP*U)-3' 2kp3 B 10 NA URS000080DE4A_32630 20071751 32630 ccauuauagc .......... .......... Structure of ANA-RNA hybrid duplex; RNA (5'-R(*CP*CP*AP*UP*UP*AP*UP*AP*GP*C)-3') 2kxz A 11 NA URS000080DF4E_32630 20481618 32630 gacaaguguca ........... ........... The Structure of RNA Internal Loops with Tandem AG Pairs: 5'AAGU/3'UGAA; 5'-R(*GP*AP*CP*AP*AP*GP*UP*GP*UP*CP*A)-3' 2kxz B 11 NA URS000080DF4E_32630 20481618 32630 gacaaguguca ........... ........... The Structure of RNA Internal Loops with Tandem AG Pairs: 5'AAGU/3'UGAA; 5'-R(*GP*AP*CP*AP*AP*GP*UP*GP*UP*CP*A)-3' 2ky0 A 11 NA URS000080E0E7_32630 20481618 32630 gacgagcguca ........... ........... The Structure of RNA Internal Loops with Tandem AG Pairs: 5'GAGC/3'CGAG; 5'-R(*GP*AP*CP*GP*AP*GP*CP*GP*UP*CP*A)-3' 2ky0 B 11 NA URS000080E0E7_32630 20481618 32630 gacgagcguca ........... ........... The Structure of RNA Internal Loops with Tandem AG Pairs: 5'GAGC/3'CGAG; 5'-R(*GP*AP*CP*GP*AP*GP*CP*GP*UP*CP*A)-3' 2ky1 A 11 NA URS000080DDE6_32630 20481618 32630 gacuagaguca ........... ........... The Structure of RNA Internal Loops with Tandem AG Pairs: 5'UAGA/3'AGAU; 5'-R(*GP*AP*CP*UP*AP*GP*AP*GP*UP*CP*A)-3' 2ky1 B 11 NA URS000080DDE6_32630 20481618 32630 gacuagaguca ........... ........... The Structure of RNA Internal Loops with Tandem AG Pairs: 5'UAGA/3'AGAU; 5'-R(*GP*AP*CP*UP*AP*GP*AP*GP*UP*CP*A)-3' 2kyd A 16 NA URS000080E1FE_32630 20549304 32630 cuaguuagcuaacuag ................ ................ RDC and RCSA refinement of an A-form RNA: Improvements in Major Groove Width; RNA (5'-R(*CP*UP*AP*GP*UP*UP*AP*GP*CP*UP*AP*AP*CP*UP*AP*G)-3') 2kyd B 16 NA URS000080E1FE_32630 20549304 32630 cuaguuagcuaacuag ................ ................ RDC and RCSA refinement of an A-form RNA: Improvements in Major Groove Width; RNA (5'-R(*CP*UP*AP*GP*UP*UP*AP*GP*CP*UP*AP*AP*CP*UP*AP*G)-3') 2l1f A 65 NA RF00374 URS000080DD56_11801 20933521 0019072 11801 ggcggacccgugguggaacagacguguucggaacacccggccgcaacccugggagacgucccagg ..<<<..<<<.<<<<<<<<......>>>>....>>>>>>>>>>....<<<<<<<....>>>>>>> .((((..(((.(((((((((....)))))....)))))))))))...(((((((....))))))) Structure of a conserved retroviral RNA packaging element by NMR spectroscopy and cryo-electron tomography; RNA (65-MER) 2l1f B 66 NA RF00374 URS000080DE60_11801 20933521 0019072 11801 ggcggacccgugguggaacagacguguucggaacacccggccgcaacccugggagacgucccaggg ..<<<..<<<.<<<<<<<<......>>>>....>>>>>>>>>>...<<<<<<<......>>>>>>> .((((..(((.(((((((((....)))))....)))))))))))..((((((((....)))))))) Structure of a conserved retroviral RNA packaging element by NMR spectroscopy and cryo-electron tomography; RNA (66-MER) 2l8f A 11 NA URS000080E294_32630 21778280 32630 gugaagcccgu ........... ........... Structure of a 4X4 Nucleotide RNA Internal Loop from an R2 Retrotransposon; RNA (5'-R(*GP*UP*GP*AP*AP*GP*CP*CP*CP*GP*U)-3') 2l8f B 11 NA URS000080E0E8_32630 21778280 32630 cggaggacacu ........... ........... Structure of a 4X4 Nucleotide RNA Internal Loop from an R2 Retrotransposon; RNA (5'-R(*CP*GP*GP*AP*GP*GP*AP*CP*AP*CP*U)-3') 2lx1 A 11 NA URS000080DEC8_32630 23134175 32630 gacgaguguca ........... ........... Major Conformation of the Internal Loop 5'GAGU/3'UGAG; RNA (5'-R(*GP*AP*CP*GP*AP*GP*UP*GP*UP*CP*A)-3') 2lx1 B 11 NA URS000080DEC8_32630 23134175 32630 gacgaguguca ........... ........... Major Conformation of the Internal Loop 5'GAGU/3'UGAG; RNA (5'-R(*GP*AP*CP*GP*AP*GP*UP*GP*UP*CP*A)-3') 2m18 A 10 NA URS000080E185_32630 23445442 32630 ggguuagggu .......... .......... Structure of stacked G-quadruplex formed by human TERRA sequence in potassium solution; RNA (5'-R(*GP*GP*GP*UP*UP*AP*GP*GP*GP*U)-3') 2m18 B 10 NA URS000080E185_32630 23445442 32630 ggguuagggu .......... .......... Structure of stacked G-quadruplex formed by human TERRA sequence in potassium solution; RNA (5'-R(*GP*GP*GP*UP*UP*AP*GP*GP*GP*U)-3') 2m18 C 10 NA URS000080E185_32630 23445442 32630 ggguuagggu .......... .......... Structure of stacked G-quadruplex formed by human TERRA sequence in potassium solution; RNA (5'-R(*GP*GP*GP*UP*UP*AP*GP*GP*GP*U)-3') 2m18 D 10 NA URS000080E185_32630 23445442 32630 ggguuagggu .......... .......... Structure of stacked G-quadruplex formed by human TERRA sequence in potassium solution; RNA (5'-R(*GP*GP*GP*UP*UP*AP*GP*GP*GP*U)-3') 2m23 A 29 NA URS000080E21D_4932 24448450 4932 ggaguauguauuggcacugagcauacucc <<<<<<<<<...........>>>>>>>>> (((((((((...........))))))))) NMR solution structure of the d3'-hairpin of the group II intron Sc.ai5gamma including EBS1 bound to IBS1; RNA (29-MER) 2mi0 A 22 NA URS000080E116_5140 24325625 5140 gagcagcaucgucggcugcuca <<<<<<<.......>>>>>>>. (((((((......).)))))). NMR structure of the I-V kissing-loop interaction of the Neurospora VS ribozyme; 5'-R(*GP*AP*GP*CP*AP*GP*CP*AP*UP*CP*GP*UP*CP*GP*GP*CP*UP*GP*CP*UP*CP*A)-3' 2mi0 B 21 NA URS000080DF57_5140 24325625 5140 gcggcaguugacuacugucgc <<<<<<<<.....>>>>>>>> (((((((.......))))))) NMR structure of the I-V kissing-loop interaction of the Neurospora VS ribozyme; 5'-R(*GP*CP*GP*GP*CP*AP*GP*UP*UP*GP*AP*CP*UP*AP*CP*UP*GP*UP*CP*GP*C)-3' 2mkn B 19 NA URS000080DE3E_32630 24521053 32630 gccguggucugguggccgg ................... ................... Structural Characterization of Interactions between the Double-Stranded RNA-Binding Zinc Finger Protein JAZ and dsRNA; RNA (5'-R(*GP*CP*CP*GP*UP*GP*GP*UP*CP*UP*GP*GP*UP*GP*GP*CP*CP*GP*G)-3') 2mkn C 19 NA URS000080E320_32630 24521053 32630 ccggccaccagaccacggc ................... ................... Structural Characterization of Interactions between the Double-Stranded RNA-Binding Zinc Finger Protein JAZ and dsRNA; RNA (5'-R(P*CP*CP*GP*GP*CP*CP*AP*CP*CP*AP*GP*AP*CP*CP*AP*CP*GP*GP*C)-3') 2mvs 1 10 NA URS000086850F_32630 25611135 32630 ggncuagucc .......... .......... N6-Methyladenosine RNA; N-6_Methyl_Adenosine_RNA 2mvs 2 10 NA URS000086850F_32630 25611135 32630 ggncuagucc .......... .......... N6-Methyladenosine RNA; N-6_Methyl_Adenosine_RNA 2mvy 1 10 NA URS000086850F_32630 25611135 32630 ggacuagucc .......... .......... Structure and Stability of RNAs Containing N6-Methyl-adenosine; RNA 2mvy 2 10 NA URS000086850F_32630 25611135 32630 ggacuagucc .......... .......... Structure and Stability of RNAs Containing N6-Methyl-adenosine; RNA 2mxk B 10 NA URS00008116B7_32630 25909229 32630 ugggagugca .......... .......... Structural features of a 3' splice site influenza A: 19-nt duplex; RNA (5'-R(*UP*GP*GP*GP*AP*GP*UP*GP*CP*A)-3') 2nok A 24 3.0 URS000080DF3C_32630 17131443 32630 cggaggaacuacugucuucacgcc ........................ ........................ Crystal Structure of an RNA domain from Hepatitis C virus.; 5'-R(*CP*GP*GP*AP*GP*GP*AP*AP*CP*UP*AP*CP*UP*GP*UP*CP*UP*UP*CP*AP*CP*GP*CP*C)-3' 2nok B 20 3.0 URS000080E21F_32630 17131443 32630 gcgugucgugcagccuccgg .................... .................... Crystal Structure of an RNA domain from Hepatitis C virus.; 5'-R(*GP*CP*GP*UP*GP*UP*CP*GP*UP*GP*CP*AP*GP*CP*CP*UP*CP*CP*GP*G)-3' 2nok C 24 3.0 URS000080DF3C_32630 17131443 32630 cggaggaacuacugucuucacgcc ........................ ........................ Crystal Structure of an RNA domain from Hepatitis C virus.; 5'-R(*CP*GP*GP*AP*GP*GP*AP*AP*CP*UP*AP*CP*UP*GP*UP*CP*UP*UP*CP*AP*CP*GP*CP*C)-3' 2nok D 20 3.0 URS000080E21F_32630 17131443 32630 gcgugucgugcagccuccgg .................... .................... Crystal Structure of an RNA domain from Hepatitis C virus.; 5'-R(*GP*CP*GP*UP*GP*UP*CP*GP*UP*GP*CP*AP*GP*CP*CP*UP*CP*CP*GP*G)-3' 2noq A 190 7.3 RF00458 URS000080E076_12136 17115051 0043022 12136 aaaaaugugaucuugcuuguaaauacaauuuugagagguuaauaaauuacaaguagugcuauuuuuguauuuagguuagcuauuuagcuuuacguuccaggaugccuaguggcagccccacaauauccaggaagcccucucugcgguuuuucagauuagguagucgaaaaaccuaagaaauuuaccugcu <<<<<.........<<<<<<<<..........(((((.........>>>>>>>>.......>>>>>......<<<<.<<<<....>>>>.....((((.((((>>>>.<<<<.....>>>>...)))).))))...)))))...<<<<<<<<....(((((((..>>>>>>>>........))))))).. (((((........(((((((((.(........[[[[[.......).)))))))))......))))).....[[[[[.((((....)))).....((((.((((]]]]]((((.....))))...)))).))))...]]]]]......(((((.....[.[[[[..)))))...........]]]].]... Structure of ribosome-bound cricket paralysis virus IRES RNA; CrPV IRES 2noq B 46 7.3 RF00177 URS000080E36E_4932 17115051 0003735 0005840 4932 gcgccggccaacuccgugccagcagccgcgguaauacggagggcgc <<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>> ((((([[[...(((((.....((.]]])).......)))))))))) Structure of ribosome-bound cricket paralysis virus IRES RNA; 18S ribosomal RNA 2noq C 13 7.3 URS000080E17D_4932 17115051 4932 gcugcauggccgu ............. ............. Structure of ribosome-bound cricket paralysis virus IRES RNA; 18S ribosomal RNA 2noq D 15 7.3 URS000080E239_4932 17115051 4932 ucuggucagcauggc ............... ............... Structure of ribosome-bound cricket paralysis virus IRES RNA; 18S ribosomal RNA 2npy A 13 2.65 URS000080DE13_32630 17582172 32630 ucccnguccaccg ............. ............. Crystal Structure of a junctioned hairpin ribozyme incorporating 9atom linker and 2'-deoxy 2'-amino U at A-1; 5'-R(*UP*CP*CP*CP*(U2N)P*GP*UP*CP*CP*AP*CP*CP*G)-3' 2npy B 12 2.65 URS000080DF3F_32630 17582172 32630 cggugagaaggg ............ ............ Crystal Structure of a junctioned hairpin ribozyme incorporating 9atom linker and 2'-deoxy 2'-amino U at A-1; 5'-R(*CP*GP*GP*UP*GP*AP*GP*AP*AP*GP*GP*G)-3' 2npy C 17 2.65 URS000080DEF8_32630 17582172 32630 ggcagagaaacacacga ................. ................. Crystal Structure of a junctioned hairpin ribozyme incorporating 9atom linker and 2'-deoxy 2'-amino U at A-1; 5'-R(*GP*GP*CP*AP*GP*AP*GP*AP*AP*AP*CP*AP*CP*AP*CP*GP*A)-3' 2npy D 19 2.65 URS000080E34C_32630 17582172 32630 ucgugguacauuaccugcc ................... ................... Crystal Structure of a junctioned hairpin ribozyme incorporating 9atom linker and 2'-deoxy 2'-amino U at A-1; 5'-R(*UP*CP*GP*UP*GP*GP*UP*AP*CP*AP*UP*UP*AP*CP*CP*UP*GP*CP*C)-3' 2npz A 13 3.35 URS000080E09E_32630 17582172 32630 ucccaguccaccg ............. ............. Crystal structure of junctioned hairpin ribozyme incorporating synthetic propyl linker; 5'-R(*UP*CP*CP*CP*AP*GP*UP*CP*CP*AP*CP*CP*G)-3' 2npz B 12 3.35 URS000080DF3F_32630 17582172 32630 cggugagaaggg ............ ............ Crystal structure of junctioned hairpin ribozyme incorporating synthetic propyl linker; 5'-R(*CP*GP*GP*UP*GP*AP*GP*AP*AP*GP*GP*G)-3' 2npz C 17 3.35 URS000080DEF8_32630 17582172 32630 ggcagagaaacacacga ................. ................. Crystal structure of junctioned hairpin ribozyme incorporating synthetic propyl linker; 5'-R(*GP*GP*CP*AP*GP*AP*GP*AP*AP*AP*CP*AP*CP*AP*CP*GP*A)-3' 2npz D 19 3.35 URS000080E34C_32630 17582172 32630 ucgugguacauuaccugcc ................... ................... Crystal structure of junctioned hairpin ribozyme incorporating synthetic propyl linker; 5'-R(*UP*CP*GP*UP*GP*GP*UP*AP*CP*AP*UP*UP*AP*CP*CP*UP*GP*CP*C)-3' 2nuf C 28 2.5 URS000080DD89_32630 18047582 32630 caaggucauucgcaagaguggccuugcg <<<<<<<<<<<....>>>>>>>>>>>.. (((((((((((....))))))))))).. Crystal structure of RNase III from Aquifex aeolicus complexed with ds-RNA at 2.5-Angstrom Resolution; 28-MER 2nuf D 28 2.5 URS000080DD89_32630 18047582 32630 caaggucauucgcaagaguggccuugcg <<<<<<<<<<<....>>>>>>>>>>>.. (((((((((((....))))))))))).. Crystal structure of RNase III from Aquifex aeolicus complexed with ds-RNA at 2.5-Angstrom Resolution; 28-MER 2nug C 11 1.7 URS000080DF34_32630 18047582 32630 aaggucauucg ........... ........... Crystal structure of RNase III from Aquifex aeolicus complexed with ds-RNA at 1.7-Angstrom Resolution; 5'-R(P*AP*AP*GP*GP*UP*CP*AP*UP*UP*CP*G)-3' 2nug E 11 1.7 URS000080DDD6_32630 18047582 32630 aguggccuugc ........... ........... Crystal structure of RNase III from Aquifex aeolicus complexed with ds-RNA at 1.7-Angstrom Resolution; 5'-R(P*AP*GP*UP*GP*GP*CP*CP*UP*UP*GP*C)-3' 2nug D 11 1.7 URS000080DF34_32630 18047582 32630 aaggucauucg ........... ........... Crystal structure of RNase III from Aquifex aeolicus complexed with ds-RNA at 1.7-Angstrom Resolution; 5'-R(P*AP*AP*GP*GP*UP*CP*AP*UP*UP*CP*G)-3' 2nug F 11 1.7 URS000080DDD6_32630 18047582 32630 aguggccuugc ........... ........... Crystal structure of RNase III from Aquifex aeolicus complexed with ds-RNA at 1.7-Angstrom Resolution; 5'-R(P*AP*GP*UP*GP*GP*CP*CP*UP*UP*GP*C)-3' 2nz4 E 13 2.498 URS000080E2F9_1392 17196404 1392 angcgccagaacu ............. ............. Structural investigation of the GlmS ribozyme bound to its catalytic cofactor; substrate strand RNA 13-mer 2nz4 P 141 2.498 RF00234 URS000080E011_1392 17196404 0003824 0010468 1392 ngcaccauugcacuccggugccaguugacgaggugggguuuaucgagauuucggcggaugacucccgguuguucaucacaaccgcaagcuuuuacuuaaaucauuaaggugacuuaguggacaaaggugaaagugugauga <<<<<<..........>>>>>>......(((...<<<<<<..)))..............>>>>>><<<<<<.(((((.>>>>>>...<<<<<<<<<....<<<<<<<<....>>>>>>>.>....>>>>>>>>>..))))) ((((((..........))))))......[[[...((((((..]]]..............))))))((((((.[[[[[[))))))...(((.(((((.....(((((((....)))))))......))))).))).]]]]]] Structural investigation of the GlmS ribozyme bound to its catalytic cofactor; GlmS ribozyme 2nz4 F 13 2.498 URS000080E2F9_1392 17196404 1392 angcgccagaacu ............. ............. Structural investigation of the GlmS ribozyme bound to its catalytic cofactor; substrate strand RNA 13-mer 2nz4 Q 141 2.498 RF00234 URS000080E011_1392 17196404 0003824 0010468 1392 ngcaccauugcacuccggugccaguugacgaggugggguuuaucgagauuucggcggaugacucccgguuguucaucacaaccgcaagcuuuuacuuaaaucauuaaggugacuuaguggacaaaggugaaagugugauga <<<<<<..........>>>>>>......(((...<<<<<<..)))..............>>>>>><<<<<<.((((((>>>>>>...<<<<<<<<<....<<<<<<<<....>>>>>>>.>....>>>>>>>>>.)))))) ((((((..........))))))......[[[...((((((..]]]..............))))))((((((.[[[[[[))))))...(((((((((.....(((((((....)))))))......))))))))).]]]]]] Structural investigation of the GlmS ribozyme bound to its catalytic cofactor; GlmS ribozyme 2nz4 G 13 2.498 URS000080E2F9_1392 17196404 1392 angcgccagaacu ............. ............. Structural investigation of the GlmS ribozyme bound to its catalytic cofactor; substrate strand RNA 13-mer 2nz4 R 141 2.498 RF00234 URS000080E011_1392 17196404 0003824 0010468 1392 ngcaccauugcacuccggugccaguugacgaggugggguuuaucgagauuucggcggaugacucccgguuguucaucacaaccgcaagcuuuuacuuaaaucauuaaggugacuuaguggacaaaggugaaagugugauga <<<<<<..........>>>>>>......(((...<<<<<<..)))..............>>>>>><<<<<<.((((((>>>>>>...<<<<<<<<<....<<<<<<<<....>>>>>>>.>....>>>>>>>>>.)))))) ((((((..........))))))......[[[...((((((..]]]..............))))))((((((.[[[[[[))))))...(((((((((.....(((((((....)))))))......))))))))).]]]]]] Structural investigation of the GlmS ribozyme bound to its catalytic cofactor; GlmS ribozyme 2nz4 H 13 2.498 URS000080E2F9_1392 17196404 1392 angcgccagaacu ............. ............. Structural investigation of the GlmS ribozyme bound to its catalytic cofactor; substrate strand RNA 13-mer 2nz4 S 141 2.498 RF00234 URS000080E011_1392 17196404 0003824 0010468 1392 ngcaccauugcacuccggugccaguugacgaggugggguuuaucgagauuucggcggaugacucccgguuguucaucacaaccgcaagcuuuuacuuaaaucauuaaggugacuuaguggacaaaggugaaagugugauga <<<<<<..........>>>>>>......(((...<<<<<<..)))..............>>>>>><<<<<<.((((((>>>>>>...<<<<<<<<<....<<<<<<<<....>>>>>>>.>....>>>>>>>>>.)))))) ((((((..........))))))......[[[...((((((..]]]..............))))))((((((.[[[[[[))))))...(((((((((.....(((((((....)))))))......))))))))).]]]]]] Structural investigation of the GlmS ribozyme bound to its catalytic cofactor; GlmS ribozyme 2o3v A 22 2.8 URS000080DDFE_32630 17705310 32630 ugcgucgcuccggaaaagucgc ...................... ...................... Crystal Structure of the Homo sapiens Cytoplasmic Ribosomal Decoding Site complexed with paromamine derivative NB33; RNA (5'-R(*UP*UP*GP*CP*GP*UP*CP*GP*CP*UP*CP*CP*GP*GP*AP*AP*AP*AP*GP*UP*CP*GP*C)-3') 2o3v B 21 2.8 URS000080DDFE_32630 17705310 32630 gcgucgcuccggaaaagucgc ..................... ..................... Crystal Structure of the Homo sapiens Cytoplasmic Ribosomal Decoding Site complexed with paromamine derivative NB33; RNA (5'-R(*UP*UP*GP*CP*GP*UP*CP*GP*CP*UP*CP*CP*GP*GP*AP*AP*AP*AP*GP*UP*CP*GP*C)-3') 2o3w A 22 2.8 URS000080DDFE_32630 17705310 32630 ugcgucgcuccggaaaagucgc ...................... ...................... Crystal Structure of the Homo sapiens Cytoplasmic Ribosomal Decoding Site in presence of paromomycin; RNA (5'-R(*UP*UP*GP*CP*GP*UP*CP*GP*CP*UP*CP*CP*GP*GP*AP*AP*AP*AP*GP*UP*CP*GP*C)-3') 2o3w B 21 2.8 URS000080DDFE_32630 17705310 32630 gcgucgcuccggaaaagucgc ..................... ..................... Crystal Structure of the Homo sapiens Cytoplasmic Ribosomal Decoding Site in presence of paromomycin; RNA (5'-R(*UP*UP*GP*CP*GP*UP*CP*GP*CP*UP*CP*CP*GP*GP*AP*AP*AP*AP*GP*UP*CP*GP*C)-3') 2o3x A 21 2.9 URS000080E29E_32630 17705310 32630 gcgucacaccggugaagucgc ..................... ..................... Crystal Structure of the Prokaryotic Ribosomal Decoding Site Complexed with Paromamine Derivative NB30; RNA (5'-R(*UP*UP*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*C)-3') 2o3x B 21 2.9 URS000080E29E_32630 17705310 32630 gcgucacaccggugaagucgc ..................... ..................... Crystal Structure of the Prokaryotic Ribosomal Decoding Site Complexed with Paromamine Derivative NB30; RNA (5'-R(*UP*UP*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*C)-3') 2o3y A 22 2.7 URS000080DDFE_32630 17705310 32630 ugcgucgcuccggaaaagucgc ...................... ...................... Crystal Structure of the Homo sapiens Cytoplasmic Ribosomal Decoding Site in Presence of Paromamine Derivative NB30; RNA (5'-R(*UP*UP*GP*CP*GP*UP*CP*GP*CP*UP*CP*CP*GP*GP*AP*AP*AP*AP*GP*UP*CP*GP*C)-3') 2o3y B 21 2.7 URS000080DDFE_32630 17705310 32630 gcgucgcuccggaaaagucgc ..................... ..................... Crystal Structure of the Homo sapiens Cytoplasmic Ribosomal Decoding Site in Presence of Paromamine Derivative NB30; RNA (5'-R(*UP*UP*GP*CP*GP*UP*CP*GP*CP*UP*CP*CP*GP*GP*AP*AP*AP*AP*GP*UP*CP*GP*C)-3') 2oe5 A 16 1.51 URS000080E0E3_32630 17258916 32630 ggcgucgcuaguaccg ................ ................ 1.5 A X-ray crystal structure of Apramycin complex with RNA fragment GGCGUCGCUAGUACCG/GGUACUAAAAGUCGCCC containing the human ribosomal decoding A site: RNA construct with 3'-overhang; RNA (5'-R(*GP*GP*CP*GP*UP*CP*GP*CP*UP*AP*GP*UP*AP*CP*CP*G)-3') 2oe5 B 17 1.51 URS000080E0F2_32630 17258916 32630 gguacuaaaagucgccc ................. ................. 1.5 A X-ray crystal structure of Apramycin complex with RNA fragment GGCGUCGCUAGUACCG/GGUACUAAAAGUCGCCC containing the human ribosomal decoding A site: RNA construct with 3'-overhang; RNA (5'-R(*GP*GP*UP*AP*CP*UP*AP*AP*AP*AP*GP*UP*CP*GP*CP*CP*C)-3') 2oe6 A 16 2.4 URS000080DDFB_32630 17258916 32630 gggcgucgcuaguacc ................ ................ 2.4A X-ray crystal structure of unliganded RNA fragment GGGCGUCGCUAGUACC/CGGUACUAAAAGUCGCC containing the human ribosomal decoding A site: RNA construct with 5'-overhang; RNA (5'-R(*GP*GP*GP*CP*GP*UP*CP*GP*CP*UP*AP*GP*UP*AP*CP*C)-3') 2oe6 B 17 2.4 URS000080E1C5_32630 17258916 32630 cgguacuaaaagucgcc ................. ................. 2.4A X-ray crystal structure of unliganded RNA fragment GGGCGUCGCUAGUACC/CGGUACUAAAAGUCGCC containing the human ribosomal decoding A site: RNA construct with 5'-overhang; RNA (5'-R(*CP*GP*GP*UP*AP*CP*UP*AP*AP*AP*AP*GP*UP*CP*GP*CP*C)-3') 2oe8 A 16 1.8 URS000080DDFB_32630 17258916 32630 gggcgucgcuaguacc ................ ................ 1.8 A X-ray crystal structure of Apramycin complex with RNA fragment GGGCGUCGCUAGUACC/CGGUACUAAAAGUCGCC containing the human ribosomal decoding A site: RNA construct with 5'-overhang; RNA (5'-R(*GP*GP*GP*CP*GP*UP*CP*GP*CP*UP*AP*GP*UP*AP*CP*C)-3') 2oe8 B 17 1.8 URS000080E1C5_32630 17258916 32630 cgguacuaaaagucgcc ................. ................. 1.8 A X-ray crystal structure of Apramycin complex with RNA fragment GGGCGUCGCUAGUACC/CGGUACUAAAAGUCGCC containing the human ribosomal decoding A site: RNA construct with 5'-overhang; RNA (5'-R(*CP*GP*GP*UP*AP*CP*UP*AP*AP*AP*AP*GP*UP*CP*GP*CP*C)-3') 2oeu A 43 2.0 RF00163 URS000080DF75_32630 18420140 3.1.-.- 0004540 32630 ngauguacuaccagcugaugagucccaaauaggacgaaacgcc .....................<<<<......>>>>........ ..............(....).((((......))))........ Full-length hammerhead ribozyme with Mn(II) bound; Hammerhead Ribozyme 2oeu B 20 2.0 URS000080DDC4_32630 18420140 32630 ggcguncuggnauccaaucc .................... .................... Full-length hammerhead ribozyme with Mn(II) bound; 5'-R(*GP*GP*CP*GP*UP*(OMC)P*CP*UP*GP*GP*(5BU)P*AP*UP*CP*CP*AP*AP*UP*CP*(DC))-3' 2oij A 23 2.31 URS000080DD3F_32630 12736317 32630 cuugcugaagcgcgcacggcaag ....................... ....................... HIV-1 subtype B DIS RNA extended duplex AuCl3 soaked; 5'-R(*CP*UP*UP*GP*CP*UP*GP*AP*AP*GP*CP*GP*CP*GP*CP*AP*CP*GP*GP*CP*AP*AP*G)-3' 2oij B 23 2.31 URS000080DD3F_32630 12736317 32630 cuugcugaagcgcgcacggcaag ....................... ....................... HIV-1 subtype B DIS RNA extended duplex AuCl3 soaked; 5'-R(*CP*UP*UP*GP*CP*UP*GP*AP*AP*GP*CP*GP*CP*GP*CP*AP*CP*GP*GP*CP*AP*AP*G)-3' 2oiy A 23 1.6 URS000080DD3F_32630 20460458 32630 cuugcugaagcgcgcacggcaag ....................... ....................... Crystal structure of the duplex form of the HIV-1(LAI) RNA dimerization initiation site; 5'-R(*CP*UP*UP*GP*CP*UP*GP*AP*AP*GP*CP*GP*CP*GP*CP*AP*CP*GP*GP*CP*AP*AP*G)-3' 2oiy B 23 1.6 URS000080DD3F_32630 20460458 32630 cuugcugaagcgcgcacggcaag ....................... ....................... Crystal structure of the duplex form of the HIV-1(LAI) RNA dimerization initiation site; 5'-R(*CP*UP*UP*GP*CP*UP*GP*AP*AP*GP*CP*GP*CP*GP*CP*AP*CP*GP*GP*CP*AP*AP*G)-3' 2oj0 A 23 2.6 URS000080DD3F_32630 20460458 32630 cuugcugaagcgcgcacggcaag ....................... ....................... Crystal structure of the duplex form of the HIV-1(LAI) RNA dimerization initiation site MN soaked; 5'-R(*CP*UP*UP*GP*CP*UP*GP*AP*AP*GP*CP*GP*CP*GP*CP*AP*CP*GP*GP*CP*AP*AP*G)-3' 2oj0 B 23 2.6 URS000080DD3F_32630 20460458 32630 cuugcugaagcgcgcacggcaag ....................... ....................... Crystal structure of the duplex form of the HIV-1(LAI) RNA dimerization initiation site MN soaked; 5'-R(*CP*UP*UP*GP*CP*UP*GP*AP*AP*GP*CP*GP*CP*GP*CP*AP*CP*GP*GP*CP*AP*AP*G)-3' 2om7 B 10 7.3 URS000080DEFC_274 17349960 274 uuccgcggag ..<<<>>>.. (.((()))). Structural Basis for Interaction of the Ribosome with the Switch Regions of GTP-bound Elongation Factors; Fragment of 16S rRNA (h15) 2om7 D 13 7.3 RF00177,RF01959,RF01960 URS000080E0A6_274 17349960 0003735 0005840 274 gacaugcgcaguu <<<.<<..>>>>> (((.((..))))) Structural Basis for Interaction of the Ribosome with the Switch Regions of GTP-bound Elongation Factors; 16S ribosomal RNA (H5) 2om7 M 74 7.3 RF00005 URS000080E2DD_274 17349960 0030533 0006412 274 uccguganaacaaagcggnnauguaccggauuuuuauuccggcuaunggggnucaauuccccgucgcggagcca <<<<<<<..<<<.........>>>.<<<<<.......>>>>>....<<<<<.......>>>>>>>>>>>>.... (((((((..(((.....[...))).(((((.......)))))....(((((..]....)))))))))))).... Structural Basis for Interaction of the Ribosome with the Switch Regions of GTP-bound Elongation Factors; p/E-tRNA 2oom A 16 NA URS000080DDA7_32630 17768146 32630 ggagccugggagcucc <<<<<......>>>>> (((((......))))) NMR structure of a kissing complex formed between the TAR RNA element of HIV-1 and a LNA/RNA aptamer; RNA 16-mer 2oom B 16 NA URS000080E0B9_32630 17768146 32630 cacgguccnngacgug <<<<........>>>> ((((........)))) NMR structure of a kissing complex formed between the TAR RNA element of HIV-1 and a LNA/RNA aptamer; TAR RNA element of HIV-1 2otj 0 2754 2.9 RF02540,RF00002 URS000080DFCD_2238 17321546 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagccauggggagccgcacggaggcgaagaaccauggauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaaugugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucucgacgaagucucuuggaacagagcgugauacagggugacaaccccguacucgagaccaguacgacgugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccucgacgaaugaccgacgcgcgagcguccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucugcauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgccguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaaguaggggugaaaacuccuauggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucauaccgcaacucgacuaugacgaaaugggaaacggguuaauauucccgugccacuaugcagugaaaguugacgcccuggggucgaucacgcugggcaucgcccagucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcauaguguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcgaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggcuaucucagccggggacccggcgaagagugcaagagcaaaagauagcuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcugggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa 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13-deoxytedanolide bound to the large subunit of Haloarcula marismortui; 23S ribosomal RNA 2otj 9 122 2.9 RF00001 URS00003592C7_2238 17321546 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccggggaguacuggagugcgcgagccucugggaaacccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<<<<.....<<<<<<.<<....>>>>>>>>....>>>>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...(((((.....((((((.((....))))))))....)))))...))))))... 13-deoxytedanolide bound to the large subunit of Haloarcula marismortui; 5S ribosomal RNA 2otl 0 2754 2.7 RF02540,RF00002 URS000080DFCD_2238 17321546 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagccauggggagccgcacggaggcgaagaaccauggauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaaugugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucucgacgaagucucuuggaacagagcgugauacagggugacaaccccguacucgagaccaguacgacgugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccucgacgaaugaccgacgcgcgagcguccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucugcauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgccguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaaguaggggugaaaacuccuauggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucauaccgcaacucgacuaugacgaaaugggaaacggguuaauauucccgugccacuaugcagugaaaguugacgcccuggggucgaucacgcugggcaucgcccagucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcauaguguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcgaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggcuaucucagccggggacccggcgaagagugcaagagcaaaagauagcuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcugggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa 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...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......(..(.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......)..)...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......(...(((.....))).............)).....)))))))))......(.((((((((((....((((((..((....(....(((((....))))).....)...))..))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Girodazole bound to the large subunit of Haloarcula marismortui; 23S ribosomal RNA 2otl 9 122 2.7 RF00001 URS00003592C7_2238 17321546 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccggggaguacuggagugcgcgagccucugggaaacccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<<<<.....<<<<<<.<<....>>>>>>>>....>>>>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...(((((.....((((((.((....))))))))....)))))...))))))... Girodazole bound to the large subunit of Haloarcula marismortui; 5S ribosomal RNA 2oue A 13 2.05 URS000080E09E_32630 16411744 32630 ucccnguccaccg ............. ............. Crystal structure of a junctionless all-RNA hairpin ribozyme at 2.05 angstroms resolution; Substrate strand - Minimal Junctionless Hairpin Ribozyme 2oue B 12 2.05 URS000080DF3F_32630 16411744 32630 cggugagaaggg ............ ............ Crystal structure of a junctionless all-RNA hairpin ribozyme at 2.05 angstroms resolution; Loop A ribozyme strand 2oue C 17 2.05 URS000080DEF8_32630 16411744 32630 ggcagagaaacacacga ................. ................. Crystal structure of a junctionless all-RNA hairpin ribozyme at 2.05 angstroms resolution; Loop B ribozyme strand 2oue D 19 2.05 URS000080E34C_32630 16411744 32630 ucgugguacauuaccugcc ................... ................... Crystal structure of a junctionless all-RNA hairpin ribozyme at 2.05 angstroms resolution; Loop B S-turn strand 2p7d B 13 2.25 URS000080DFAF_32630 17488874,16411744,16262240 32630 cggugagaagggn ............. ............. A Minimal, 'Hinged' Hairpin Ribozyme Construct Solved with Mimics of the Product Strands at 2.25 Angstroms Resolution; Ribozyme strand I 2p7d C 17 2.25 URS000080DEF8_32630 17488874,16411744,16262240 32630 ggcagagaaacacacga ................. ................. A Minimal, 'Hinged' Hairpin Ribozyme Construct Solved with Mimics of the Product Strands at 2.25 Angstroms Resolution; Ribozyme strand II 2p7d D 19 2.25 URS000080E34C_32630 17488874,16411744,16262240 32630 ucgugguacauuaccugcc ................... ................... A Minimal, 'Hinged' Hairpin Ribozyme Construct Solved with Mimics of the Product Strands at 2.25 Angstroms Resolution; Ribozyme strand III 2p7e B 13 2.05 URS000080DFAF_32630 17488874,16411744,16262240 32630 cggugagaagggn ............. ............. Vanadate at the Active Site of a Small Ribozyme Suggests a Role for Water in Transition-State Stabilization; Ribozyme strand I 2p7e C 17 2.05 URS000080DEF8_32630 17488874,16411744,16262240 32630 ggcagagaaacacacga ................. ................. Vanadate at the Active Site of a Small Ribozyme Suggests a Role for Water in Transition-State Stabilization; Ribozyme strand II 2p7e D 19 2.05 URS000080E34C_32630 17488874,16411744,16262240 32630 ucgugguacauuaccugcc ................... ................... Vanadate at the Active Site of a Small Ribozyme Suggests a Role for Water in Transition-State Stabilization; Ribozyme strand III 2p7f A 13 2.35 URS000080E09E_32630 17488874,16411744,16262240 32630 ucccnguccaccg ............. ............. The Novel Use of a 2',5'-Phosphodiester Linkage as a Reaction Intermediate at the Active Site of a Small Ribozyme; substrate strand 2p7f B 12 2.35 URS000080DF3F_32630 17488874,16411744,16262240 32630 cggugagaaggg ............ ............ The Novel Use of a 2',5'-Phosphodiester Linkage as a Reaction Intermediate at the Active Site of a Small Ribozyme; Loop A ribozyme strand 2p7f C 17 2.35 URS000080DEF8_32630 17488874,16411744,16262240 32630 ggcagagaaacacacga ................. ................. The Novel Use of a 2',5'-Phosphodiester Linkage as a Reaction Intermediate at the Active Site of a Small Ribozyme; Loop B ribozyme strand 2p7f D 19 2.35 URS000080E34C_32630 17488874,16411744,16262240 32630 ucgugguacauuaccugcc ................... ................... The Novel Use of a 2',5'-Phosphodiester Linkage as a Reaction Intermediate at the Active Site of a Small Ribozyme; Loop B S-turn strand 2p89 A 34 NA URS000080E1BE_9606 17412831 9606 ggccuuaggaaacaguucgcugugccgaaagguc .<<<<......<<<<<..>>>>>......>>>>. (((((......((((....))))......))))) Solution structure of the 3' pseudouridyation pocket of U65 snoRNA with bound substrate; U65 H/ACA snoRNA 2p89 B 14 NA URS000080DD4B_9606 17412831 9606 uucggcucuuccua .............. .............. Solution structure of the 3' pseudouridyation pocket of U65 snoRNA with bound substrate; 28S rRNA 2pcw A 35 NA URS000080E11B_9606 17466623 9606 ggacccgccacugcagagaugcaauccaguggucc <<<<.......<<<<....>>>>........>>>> (((((......((((....)))).......))))) Solution Structure of an rRNA Substrate Bound to the Pseudouridylation Pocket of a Box H/ACA snoRNA; U65 box H/ACA snoRNA 2pcw B 14 NA URS000080E1DC_9606 17466623 9606 acuggcuuguggcg .............. .............. Solution Structure of an rRNA Substrate Bound to the Pseudouridylation Pocket of a Box H/ACA snoRNA; rRNA substrate of U65 box H/ACA snoRNA 2pn3 A 24 2.9 URS000080DF3C_32630 18391410 32630 cggaggaacuacugucuucacgcc ........................ ........................ Crystal Structure of Hepatitis C Virus IRES Subdomain IIa; 5'-R(*CP*GP*GP*AP*GP*GP*AP*AP*CP*UP*AP*CP*UP*GP*UP*CP*UP*UP*CP*AP*CP*GP*CP*C)-3' 2pn3 B 20 2.9 URS000080E21F_32630 18391410 32630 gcgngucgugcagccnccgg .................... .................... Crystal Structure of Hepatitis C Virus IRES Subdomain IIa; 5'-R(*GP*CP*GP*(5BU)P*GP*UP*CP*GP*UP*GP*CP*AP*GP*CP*CP*(5BU)P*CP*CP*GP*G)-3' 2pn4 A 24 2.32 URS000080DF3C_32630 18391410 32630 cggaggaacuacugucuucacgcc ........................ ........................ Crystal Structure of Hepatitis C Virus IRES Subdomain IIa; 5'-R(*CP*GP*GP*AP*GP*GP*AP*AP*CP*UP*AP*CP*UP*GP*UP*CP*UP*UP*CP*AP*CP*GP*CP*C)-3' 2pn4 B 20 2.32 URS000080E21F_32630 18391410 32630 gcgngucgugcagccnccgg .................... .................... Crystal Structure of Hepatitis C Virus IRES Subdomain IIa; 5'-R(*GP*CP*GP*(5BU)P*GP*UP*CP*GP*UP*GP*CP*AP*GP*CP*CP*(5BU)P*CP*CP*GP*G)-3' 2pn4 C 24 2.32 URS000080DF3C_32630 18391410 32630 cggaggaacuacugucuucacgcc ........................ ........................ Crystal Structure of Hepatitis C Virus IRES Subdomain IIa; 5'-R(*CP*GP*GP*AP*GP*GP*AP*AP*CP*UP*AP*CP*UP*GP*UP*CP*UP*UP*CP*AP*CP*GP*CP*C)-3' 2pn4 D 20 2.32 URS000080E21F_32630 18391410 32630 gcgngucgugcagccnccgg .................... .................... Crystal Structure of Hepatitis C Virus IRES Subdomain IIa; 5'-R(*GP*CP*GP*(5BU)P*GP*UP*CP*GP*UP*GP*CP*AP*GP*CP*CP*(5BU)P*CP*CP*GP*G)-3' 2pn9 A 16 NA URS000080DDA7_32630 17768146 32630 ggagccugggagcucc <<<<<......>>>>> (((((......))))) NMR structure of a kissing complex formed between the TAR RNA element of HIV-1 and a LNA modified aptamer; 5'-R(*GP*GP*AP*GP*CP*CP*UP*GP*GP*GP*AP*GP*CP*UP*CP*C)-3' 2pn9 B 16 NA URS000080E0B9_32630 17768146 32630 cacgguccnngacgug <<<<........>>>> ((((........)))) NMR structure of a kissing complex formed between the TAR RNA element of HIV-1 and a LNA modified aptamer; RNA 16-mer with locked residues 9-10 2pwt A 21 1.8 URS000080DF2F_32630 17722211 32630 gcgucacaccggugaagucgc ..................... ..................... Crystal structure of the bacterial ribosomal decoding site complexed with aminoglycoside containing the L-HABA group; 22-mer of the ribosomal decoding site 2pwt B 21 1.8 URS000080DF2F_32630 17722211 32630 gcgucacaccggugaagucgc ..................... ..................... Crystal structure of the bacterial ribosomal decoding site complexed with aminoglycoside containing the L-HABA group; 22-mer of the ribosomal decoding site 2q1o A 12 1.1 URS000080E2B9_32630 17881374 32630 cgcnaauuggcg ............ ............ Crystal Structure Analysis of the RNA Dodecamer CGC-NF2-AAUUGGCG, with an Incorporated 2,4-Difluorotoluyl Residue (NF2); RNA (5'-R(*CP*GP*CP*(NF2)P*AP*AP*UP*UP*GP*GP*CP*G)-3') 2q1o B 12 1.1 URS000080E2B9_32630 17881374 32630 cgcnaauuggcg ............ ............ Crystal Structure Analysis of the RNA Dodecamer CGC-NF2-AAUUGGCG, with an Incorporated 2,4-Difluorotoluyl Residue (NF2); RNA (5'-R(*CP*GP*CP*(NF2)P*AP*AP*UP*UP*GP*GP*CP*G)-3') 2q1o C 12 1.1 URS000080E2B9_32630 17881374 32630 cgcnaauuggcg ............ ............ Crystal Structure Analysis of the RNA Dodecamer CGC-NF2-AAUUGGCG, with an Incorporated 2,4-Difluorotoluyl Residue (NF2); RNA (5'-R(*CP*GP*CP*(NF2)P*AP*AP*UP*UP*GP*GP*CP*G)-3') 2q1o D 12 1.1 URS000080E2B9_32630 17881374 32630 cgcnaauuggcg ............ ............ Crystal Structure Analysis of the RNA Dodecamer CGC-NF2-AAUUGGCG, with an Incorporated 2,4-Difluorotoluyl Residue (NF2); RNA (5'-R(*CP*GP*CP*(NF2)P*AP*AP*UP*UP*GP*GP*CP*G)-3') 2q1r A 12 1.12 URS000080E0B7_32630 17881374 32630 cgcgaauuagcg ............ ............ Crystal Structure Analysis of the RNA Dodecamer CGCGAAUUAGCG, with a G-A mismatch.; RNA (5'-R(*CP*GP*CP*GP*AP*AP*UP*UP*AP*GP*CP*G)-3') 2qa4 0 2753 3.0 RF02540,RF00002 URS000080DFCD_2238 17599351 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagccauggggagccgcacggaggcgaagaaccauggauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaaugugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucucgacgaagucucuuggaacagagcgugauacagggugacaaccccguacucgagaccaguacgacgugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccucgacgaaugaccgacgcgcgagcguccaguaagacucacgggaagccgauguucugucguacguuuugaaaacgagccagggagugugucugcauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgccguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaaguaggggugaaaacuccuauggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucauaccgcaacucgacuaugacgaaaugggaaacggguuaauauucccgugccacuaugcagugaaaguugacgcccuggggucgaucacgcugggcaucgcccagucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcauaguguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcgaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggcuaucucagccggggacccggcgaagagugcaagagcaaaagauagcuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcugggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa 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...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......(..(.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......)..)...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......(...(((.....))).............)).....)))))))))......(.((((((((((....((((((..((....(....(((((....))))).....)...))..))))..)).)))))))))).<.(((.......))).((((((....(((((((((((((..(((...((((.....))))...)))...((....)).....((((...((((..))))...)))).((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.(((((((.((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)).))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. A more complete structure of the the L7/L12 stalk of the Haloarcula marismortui 50S large ribosomal subunit; 23S RIBOSOMAL RNA 2qa4 9 122 3.0 RF00001 URS00003592C7_2238 17599351 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccggggaguacuggagugcgcgagccucugggaaacccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<<.............>>>>..>>....>>>>>>.>><..<<<<<.....<<<<<<.<<....>>>>>>>>....>>>>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...(((((.....((((((.((....))))))))....)))))...))))))... A more complete structure of the the L7/L12 stalk of the Haloarcula marismortui 50S large ribosomal subunit; 5S RIBOSOMAL RNA 2qek A 23 1.8 URS000080E167_32630 18435520 32630 cuugcugaagugcacacagcaag ....................... ....................... HIV-1 subtype F DIS RNA extended duplex form; HIV-1 subtype F DIS genomic RNA 2qek B 23 1.8 URS000080E167_32630 18435520 32630 cuugcugaagugcacacagcaag ....................... ....................... HIV-1 subtype F DIS RNA extended duplex form; HIV-1 subtype F DIS genomic RNA 2qex 0 2754 2.9 RF02540,RF00002 URS000080E276_2238 17664317 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagccauggggagccgcacggaggcgaagaaccauggauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaaugugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucucgacgaagucucuuggaacagagcgugauacagggugacaaccccguacucgagaccaguacgacgugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccucgacgaaugaccgacgcgcgagcguccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucugcauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgccguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaaguaggggugaaaacuccuauggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucauaccgcaacucgacuaugacgaaaugggaaacggguuaauauucccgugccacuaugcagugaaaguugacgcccuggggucgaucacgcugggcaucgcccagucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcauaguguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcgaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggcuaucucagccggggacccggcgaagagugcaagagcaaaagauagcuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcugggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>...<<<<<.....<<.....>>....>>>>>...<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<..<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>..>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<..<<....<....<<<<<....>>>>>.....>...>>..>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<...<<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>>.<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<.<<<.....>>>.>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<<..<<<<.......>>>>..>>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<<...<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>.>>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>..<<<<.....>>>>......>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......(..(.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......)..)...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......(...(((.....))).............)).....)))))))))......(.((((((((((....((((((..((....(....(((((....))))).....)...))..))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Negamycin Binds to the Wall of the Nascent Chain Exit Tunnel of the 50S Ribosomal Subunit; 23S ribosomal RNA 2qex 9 122 2.9 RF00001 URS00003592C7_2238 17664317 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccggggaguacuggagugcgcgagccucugggaaacccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<<<<.....<<<<<<.<<....>>>>>>>>....>>>>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...(((((.....((((((.((....))))))))....)))))...))))))... Negamycin Binds to the Wall of the Nascent Chain Exit Tunnel of the 50S Ribosomal Subunit; 5S ribosomal RNA 2quw A 12 2.2 URS000080E0C8_31504 18834200 31504 nggagcccugun ............ ............ Hammerhead Ribozyme G12A mutant after cleavage; Hammerhead ribozyme, cleaved fragment 2quw B 57 2.2 URS000080DFDA_31504 18834200 31504 accggaugugcuuuccggucugaugaguccgugaggacaaaacagggcucccgaauu <<<<<<.......>>>>>>.......<<<<....>>>>................... ((((((.....[.))))))(....).((((...]))))................... Hammerhead Ribozyme G12A mutant after cleavage; Hammerhead ribozyme, cleaved fragment 2quw C 12 2.2 URS000080E0C8_31504 18834200 31504 nggagcccugun ............ ............ Hammerhead Ribozyme G12A mutant after cleavage; Hammerhead ribozyme, cleaved fragment 2quw D 57 2.2 URS000080DFDA_31504 18834200 31504 accggaugugcuuuccggucugaugaguccgugaggacaaaacagggcucccgaauu <<<<<<.......>>>>>>.......<<<<....>>>>................... ((((((.....[.))))))(....).((((...]))))................... Hammerhead Ribozyme G12A mutant after cleavage; Hammerhead ribozyme, cleaved fragment 2r1s A 13 1.4 URS000080DEB6_32630 17940138 32630 gcguungaaacgc ............. ............. Structure of the RNA brominated tridecamer r(GCGUU-5BUGAAACGC) at 1.4 A (Br1); RNA (5'-R(*GP*CP*GP*UP*UP*(5BU)P*GP*AP*AP*AP*CP*GP*C)-3') 2r1s B 13 1.4 URS000080DEB6_32630 17940138 32630 gcguungaaacgc ............. ............. Structure of the RNA brominated tridecamer r(GCGUU-5BUGAAACGC) at 1.4 A (Br1); RNA (5'-R(*GP*CP*GP*UP*UP*(5BU)P*GP*AP*AP*AP*CP*GP*C)-3') 2r20 A 13 1.3 URS000080DEB6_32630 17940138 32630 gcguungaaacgc ............. ............. Structure of the RNA brominated tridecamer r(GCGUU-5BUGAAACGC) at 1.3 A (Br2); RNA (5'-R(*GP*CP*GP*UP*UP*(5BU)P*GP*AP*AP*AP*CP*GP*C)-3') 2r20 B 13 1.3 URS000080DEB6_32630 17940138 32630 gcguungaaacgc ............. ............. Structure of the RNA brominated tridecamer r(GCGUU-5BUGAAACGC) at 1.3 A (Br2); RNA (5'-R(*GP*CP*GP*UP*UP*(5BU)P*GP*AP*AP*AP*CP*GP*C)-3') 2r21 A 13 1.59 URS000080DEB6_32630 32630 gcguungaaacgc ............. ............. Structure of the RNA brominated tridecamer r(GCGUU-5BUGAAACGC) at 1.6 A (BrMn); RNA (5'-R(*GP*CP*GP*UP*UP*(5BU)P*GP*AP*AP*AP*CP*GP*C)-3') 2r21 B 13 1.59 URS000080DEB6_32630 32630 gcguungaaacgc ............. ............. Structure of the RNA brominated tridecamer r(GCGUU-5BUGAAACGC) at 1.6 A (BrMn); RNA (5'-R(*GP*CP*GP*UP*UP*(5BU)P*GP*AP*AP*AP*CP*GP*C)-3') 2r22 A 13 1.4 URS000080DEB6_32630 32630 gcguuugaaacgc ............. ............. Structure of the native RNA tridecamer r(GCGUUUGAAACGC) at 1.5 A (NatMn); RNA (5'-R(*GP*CP*GP*UP*UP*UP*GP*AP*AP*AP*CP*GP*C)-3') 2r22 B 13 1.4 URS000080DEB6_32630 32630 gcguuugaaacgc ............. ............. Structure of the native RNA tridecamer r(GCGUUUGAAACGC) at 1.5 A (NatMn); RNA (5'-R(*GP*CP*GP*UP*UP*UP*GP*AP*AP*AP*CP*GP*C)-3') 2r92 T 10 3.8 URS000080E066_32630 18004386 32630 cgccugguca .......... .......... Elongation complex of RNA polymerase II with artificial RdRP scaffold; RNA (5'-R(*CP*UP*UP*GP*AP*CP*GP*CP*CP*UP*GP*GP*UP*CP*AP*AP*A)-3') 2rfk D 21 2.87 URS000080E178_32630 18059286 32630 gggcuccggaaaccgcggcgc ..................... ..................... Substrate RNA Positioning in the Archaeal H/ACA Ribonucleoprotein Complex; guide RNA 1 2rfk E 26 2.87 URS000080DF8D_32630 18059286 32630 gcgcuucgcucccggagcccacacua .......................... .......................... Substrate RNA Positioning in the Archaeal H/ACA Ribonucleoprotein Complex; guide RNA 2 2rfk F 14 2.87 URS000080E065_32630 18059286 32630 ggagcgugcgguuu .............. .............. Substrate RNA Positioning in the Archaeal H/ACA Ribonucleoprotein Complex; target RNA 2rkj C 238 4.5 RF00028 URS000080E20D_55510 18172503 0000372 55510 gagccuuuauacaguaauguauaucgaaaaauccucuaauucagggaacaccuaaacauguaggcaauccugagcuaagcucugcggaaacgcagagaaagugcaacgacuauuccgauaggaaguagggucaagugacucgaaauggggauuacccuucuaggguagugauauagucugaacauauauggaaacauauagaaggauaggaguaacgaaccuauccguaacauaauug .......<<<<<<....>>>>>>.......<<<<<<....<<<<<<....<<<..<<..>>>>>...>>>>>><<<...<<<<<<<....>>>>>>>..>>>.....((((.<<<<....>>>>...<<<<<..[.>>>>>.....>>>>>><<<<<.....>>>>>.......))))..<<..<<<<<<....>>>>>>...<<<<<<<.....]...>>>>>>>.........>>. ....(..((((((....))))))..)....((((((....((((((.....((...(()).))....)))))).((...(((((((....)))))))..))....[.[[[[.((((....))))...(((((....))))).....))))))(((((.....))))).......]]]]].((..((((((....))))))...(((((((.........))))))).........)). Cocrystal structure of a tyrosyl-tRNA synthetase splicing factor with a group I intron RNA; RNA (238-MER) 2rkj G 238 4.5 RF00028 URS000080E20D_55510 18172503 0000372 55510 gagccuuuauacaguaauguauaucgaaaaauccucuaauucagggaacaccuaaacauguaggcaauccugagcuaagcucugcggaaacgcagagaaagugcaacgacuauuccgauaggaaguagggucaagugacucgaaauggggauuacccuucuaggguagugauauagucugaacauauauggaaacauauagaaggauaggaguaacgaaccuauccguaacauaauug .......<<<<<<....>>>>>>.......<<<<<<....<<<<<<....<<<..<<..>>>>>...>>>>>><<<...<<<<<<<....>>>>>>>..>>>.....((((.<<<<....>>>>...<<<<<..[.>>>>>.....>>>>>><<<<<<...>>>>>>.......))))..<<..<<<<<<....>>>>>>...<<<<<<<.....]...>>>>>>>.........>>. ....(..((((((....))))))..)....((((((....((((((.....((...(()).))....)))))).((...(((((((....)))))))..))....[.[[[[.((((....))))...(((((....))))).....))))))(((((.....))))).......]]]]].((..((((((....))))))...(((((((.........))))))).........)). Cocrystal structure of a tyrosyl-tRNA synthetase splicing factor with a group I intron RNA; RNA (238-MER) 2rkj K 238 4.5 RF00028 URS000080E20D_55510 18172503 0000372 55510 gagccuuuauacaguaauguauaucgaaaaauccucuaauucagggaacaccuaaacauguaggcaauccugagcuaagcucugcggaaacgcagagaaagugcaacgacuauuccgauaggaaguagggucaagugacucgaaauggggauuacccuucuaggguagugauauagucugaacauauauggaaacauauagaaggauaggaguaacgaaccuauccguaacauaauug .......<<<<<<....>>>>>>.......<<<<<<....<<<<<<....<<<..<<..>>>>>...>>>>>><<<...<<<<<<<....>>>>>>>..>>>.....((((.<<<<....>>>>...<<<<<..[.>>>>>.....>>>>>><<<<<<...>>>>>>.......))))..<<..<<<<<<....>>>>>>...<<<<<<<.....]...>>>>>>>.........>>. ....(..((((((....))))))..)....((((((....((((((.....((...(()).))....)))))).((...(((((((....)))))))..))....[.[[[[.((((....))))...(((((....))))).....))))))(((((.....))))).......]]]]].((..((((((....))))))...(((((((.........))))))).........)). Cocrystal structure of a tyrosyl-tRNA synthetase splicing factor with a group I intron RNA; RNA (238-MER) 2rkj O 238 4.5 RF00028 URS000080E20D_55510 18172503 0000372 55510 gagccuuuauacaguaauguauaucgaaaaauccucuaauucagggaacaccuaaacauguaggcaauccugagcuaagcucugcggaaacgcagagaaagugcaacgacuauuccgauaggaaguagggucaagugacucgaaauggggauuacccuucuaggguagugauauagucugaacauauauggaaacauauagaaggauaggaguaacgaaccuauccguaacauaauug .......<<<<<<....>>>>>>.......<<<<<<....<<<<<<....<<<..<<..>>>>>...>>>>>><<<...<<<<<<<....>>>>>>>..>>>.....((((.<<<<....>>>>...<<<<<..[.>>>>>.....>>>>>><<<<<.....>>>>>.......))))..<<..<<<<<<....>>>>>>...<<<<<<<.....]...>>>>>>>.........>>. ....(..((((((....))))))..)....((((((....((((((.....((...(()).))....)))))).((...(((((((....)))))))..))....[.[[[[.((((....))))...(((((....))))).....))))))(((((.....))))).......]]]]].((..((((((....))))))...(((((((.........))))))).........)). Cocrystal structure of a tyrosyl-tRNA synthetase splicing factor with a group I intron RNA; RNA (238-MER) 2rn1 A 16 NA URS000080E1E1_32630 18607001 32630 gagcccugggaggcuc <<<<<......>>>>> (((((......))))) Liquid crystal solution structure of the kissing complex formed by the apical loop of the HIV TAR RNA and a high affinity RNA aptamer optimized by SELEX; RNA (5'-R(P*GP*AP*GP*CP*CP*CP*UP*GP*GP*GP*AP*GP*GP*CP*UP*C)-3') 2rn1 B 16 NA URS000080E103_32630 18607001 32630 gcuggucccagacagc <<<<........>>>> ((((........)))) Liquid crystal solution structure of the kissing complex formed by the apical loop of the HIV TAR RNA and a high affinity RNA aptamer optimized by SELEX; RNA (5'-R(P*GP*CP*UP*GP*GP*UP*CP*CP*CP*AP*GP*AP*CP*AP*GP*C)-3') 2rqj A 12 NA URS000080E0D2_32630 19666719 32630 ggaggaggagga ............ ............ Quadruplex structure of an RNA aptamer against bovine prion protein; RNA (5'-R(*GP*GP*AP*GP*GP*AP*GP*GP*AP*GP*GP*A)-3') 2rqj B 12 NA URS000080E0D2_32630 19666719 32630 ggaggaggagga ............ ............ Quadruplex structure of an RNA aptamer against bovine prion protein; RNA (5'-R(*GP*GP*AP*GP*GP*AP*GP*GP*AP*GP*GP*A)-3') 2rsk A 12 NA URS000080E0D2_32630 23180780 32630 ggaggaggagga ............ ............ RNA aptamer against prion protein in complex with the partial binding peptide; RNA (5'-R(*GP*GP*AP*GP*GP*AP*GP*GP*AP*GP*GP*A)-3') 2rsk B 12 NA URS000080E0D2_32630 23180780 32630 ggaggaggagga ............ ............ RNA aptamer against prion protein in complex with the partial binding peptide; RNA (5'-R(*GP*GP*AP*GP*GP*AP*GP*GP*AP*GP*GP*A)-3') 2ru7 A 12 NA URS000080E0D2_32630 24803670 32630 ggaggaggagga ............ ............ Refined structure of RNA aptamer in complex with the partial binding peptide of prion protein; RNA_(5'-R(*GP*GP*AP*GP*GP*AP*GP*GP*AP*GP*GP*A)-3') 2ru7 B 12 NA URS000080E0D2_32630 24803670 32630 ggaggaggagga ............ ............ Refined structure of RNA aptamer in complex with the partial binding peptide of prion protein; RNA_(5'-R(*GP*GP*AP*GP*GP*AP*GP*GP*AP*GP*GP*A)-3') 2uu9 A 1512 3.1 RF00177,RF01959,RF01960 URS000080E226_300852 17496902 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggauccuuucu ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<<.....>>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<.<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<<....>>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>..>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>........... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.....)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((......(((((.....((((((......))))))...((((....)))).....)))))..((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..((...(((.....)))).)...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.......... Structure of the Thermus thermophilus 30S ribosomal subunit complexed with a Valine-ASL with cmo5U in position 34 bound to an mRNA with a GUG-codon in the A-site and paromomycin.; 16S RRNA 2uu9 Y 13 3.1 URS000080DE70_300852 17496902 300852 ucccunacnagga <<<.......>>> (((.......))) Structure of the Thermus thermophilus 30S ribosomal subunit complexed with a Valine-ASL with cmo5U in position 34 bound to an mRNA with a GUG-codon in the A-site and paromomycin.; RNA 2uua A 1512 2.9 RF00177,RF01959,RF01960 URS000080E226_300852 17496902 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggauccuuucu ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<<.....>>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<<....>>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>........... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.....)))))))))).)))))......(((......((((((((..((...(((((((.(((((....(((((......))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((......(((((.(...(((((((....)))))))...((((....))))....))))))..((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...(...(((.....)))).....)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((.((((((...(.((((....(((....))).)))).)..)))))).))))))..))).))))..).))...)..)..(((((((((....)))))))))}.......... Structure of the Thermus thermophilus 30S ribosomal subunit complexed with a Valine-ASL with cmo5U in position 34 bound to an mRNA with a GUC-codon in the A-site and paromomycin.; 16S RRNA 2uua Y 13 2.9 URS000080DE70_300852 17496902 300852 ucccunacnagga <<<.......>>> (((.......))) Structure of the Thermus thermophilus 30S ribosomal subunit complexed with a Valine-ASL with cmo5U in position 34 bound to an mRNA with a GUC-codon in the A-site and paromomycin.; 5'-R(*CP*CP*UP*CP*CP*CP*UP*CM0P*AP*CP*6MZP*AP *GP*GP*AP*GP*G)-3' 2uub A 1512 2.8 RF00177,RF01959,RF01960 URS000080E226_300852 17496902 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggauccuuucu ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<<.....>>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<<....>>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<<..>>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>........... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.....)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((.(...(((((((....)))))))...((((....))))....))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..((...(((.....)))).)...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.......... Structure of the Thermus thermophilus 30S ribosomal subunit complexed with a Valine-ASL with cmo5U in position 34 bound to an mRNA with a GUU-codon in the A-site and paromomycin.; 16S Ribosomal RNA 2uub Y 11 2.8 URS000080DE70_32630 17496902 32630 cccunacnagg <<.......>> ........... Structure of the Thermus thermophilus 30S ribosomal subunit complexed with a Valine-ASL with cmo5U in position 34 bound to an mRNA with a GUU-codon in the A-site and paromomycin.; 5'-R(*CP*CP*UP*CP*CP*CP*UP*CM0P*AP*CP*6MZP*AP *GP*GP*AP*GP*G)-3' 2uuc A 1512 3.1 RF00177,RF01959,RF01960 URS000080E226_300852 17496902 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggauccuuucu ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<<.....>>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<<....>>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>........... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.....)))))))))).)))))......(((......((((((((..((...(((((((.(((((....(((((......))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((....(((((((....)))))))...((((....))))....))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...(...(((.....)))).....)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.......... Structure of the Thermus thermophilus 30S ribosomal subunit complexed with a Valine-ASL with cmo5U in position 34 bound to an mRNA with a GUA-codon in the A-site and paromomycin.; 16S Ribosomal RNA 2uuc Y 13 3.1 URS000080DE70_32630 17496902 32630 ucccunacnagga <<<.......>>> (((.......))) Structure of the Thermus thermophilus 30S ribosomal subunit complexed with a Valine-ASL with cmo5U in position 34 bound to an mRNA with a GUA-codon in the A-site and paromomycin.; 5'-R(*CP*CP*UP*CP*CP*CP*UP*CM0P*AP*CP*6MZP*AP *GP*GP*AP*GP*G)-3' 2uxb A 1513 3.1 RF00177,RF01959,RF01960 URS000080E226_300852 17416634 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucacuuucu ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<.......>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<.......<<........>>..........<<<<<<<.......<<<<<<<..<<<<<<<....>>>>>>>...<<<<....>>>>..>>>>>>>..<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>....>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.((...(((..((.((((.(((((.....))))).)))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))....))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((..((..(..((((....))))..)....(((....)))...))..))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((.(...(...(.(.....).)).....).)))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((...(..((((....))))..).....))).....)))))))......(....(((.(((........))).)))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(..(((.(.(..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..).).)))...).))...)..)..(((((((((....)))))))))}........... Crystal structure of an extended tRNA anticodon stem loop in complex with its cognate mRNA GGGU in the context of the Thermus thermophilus 30S subunit.; 16S RIBOSOMAL RNA 2uxc A 1513 2.9 RF00177,RF01959,RF01960 URS000080E226_300852 17416634 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucacuuucu ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<.......>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<.........<<....>>........>>>....<.<<<........<<<<.....>>>>..........>>>.>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<<....>>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.....)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((...........................))....(..((...(....((((.....)))).....)....))..)......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((......((((((......(((((....)))))......(((....))).....))))))..((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..((...(((.....)))).)...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Crystal structure of an extended tRNA anticodon stem loop in complex with its cognate mRNA UCGU in the context of the Thermus thermophilus 30S subunit.; 16S RIBOSOMAL RNA 2uxd A 1484 3.2 RF00177,RF01959,RF01960 URS000080DEEC_300852 17416634 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgggguuuuacuccgggucagcggcggacgggugaguaacgcguggguaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgcguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugacccgggacgaaacccccacggggcugacgguaccgggguauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucacuuucu ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<.......>>>>>.>>.>>>>>......<<.......<<<<<<<<.<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<....>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<<<<<........<<<....>>>.........>>>>>.....<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<...<<<<<<<....>>>>>>>...<<<<....>>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<...>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<........>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((.....))))...)).)))))......(((......((((((((.((...(((((((.(((((....((((((....)))))).....)))))....((((....))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((.(......((((....)))).....).))....((((...(....(((....)))....)....))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((....(((((((....)))))))...(((......)))...)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.((((((....(...(((.....))))......))))))..(..(((((...))))).....)..)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((.((((((...(.((((........)))).)..)))))).))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Crystal structure of an extended tRNA anticodon stem loop in complex with its cognate mRNA CGGG in the context of the Thermus thermophilus 30S subunit.; 16S RIBOSOMAL RNA 2vqe A 1513 2.5 RF00177,RF01959,RF01960 URS000080E226_300852 18456657 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucacuuucu ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<<.....>>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<.<..<<<<<<<....>>>>>>>...<<<<....>>>>..>.>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<...<<<.....>>>.>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.....)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((.(...(((((((....)))))))....(((....))).....))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(....(((.....)))..)...)))))))......((((....)))).........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Modified uridines with C5-methylene substituents at the first position of the tRNA anticodon stabilize U-G wobble pairing during decoding; 16S RRNA 2vqf A 1513 2.9 RF00177,RF01959,RF01960 URS000080E226_300852 18456657 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucacuuucu ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<<.....>>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<.<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<<....>>>>..>>>>>>>>.<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<...<<<.....>>>.>>...>>>>>>>.....<<<<<....>>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>...>..>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.....)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((....(((((((....)))))))....(((....))).....))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(....(((.....)))..)...)))))))......((((....)))).........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Modified uridines with C5-methylene substituents at the first position of the tRNA anticodon stabilize U-G wobble pairing during decoding; 16S RRNA 2wyy R 45 10.6 URS000080E17E_11285 20133572 11285 uuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuu ............................................. ............................................. CRYOEM MODEL OF THE VESICULAR STOMATITIS VIRUS; POLY-URIDINE 2wyy S 45 10.6 URS000080E17E_11285 20133572 11285 uuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuu ............................................. ............................................. CRYOEM MODEL OF THE VESICULAR STOMATITIS VIRUS; POLY-URIDINE 2xeb A 19 NA URS000080E385_9606 20466811 9606 gaucguagccaaugagguu ................... ................... NMR STRUCTURE OF THE PROTEIN-UNBOUND SPLICEOSOMAL U4 SNRNA 5' STEM LOOP; 5'-R(P*GP*AP*UP*CP*GP*UP*AP*GP*CP*CP*AP*AP*UP*GP*AP* GP*GP*UP*U)-3' 2xeb B 14 NA URS000080DD46_9606 20466811 9606 gccgaggcgcgauc .............. .............. NMR STRUCTURE OF THE PROTEIN-UNBOUND SPLICEOSOMAL U4 SNRNA 5' STEM LOOP; 5'-R(P*GP*CP*CP*GP*AP*GP*GP*CP*GP*CP*GP*AP*UP*C)-3' 2ydh A 94 2.9 RF00162 URS000080E1B3_119072 21893284 0010468 119072 ggcuuaucaagagagguuuagggacuggcccgacgaaacccggcaaccagaaauggugccaauuccugcagcggaaacguugaaagaugagccg <<<<<<<<......<<<<..<<<...((>>>.....>>>>.<<<<.<<<....>>>>>>>....))<.<<<<<....>>>>>..>>>>>>>>>. ((((((((....(.(((...(((.[.[[)))......))))(((..(((....))).)))...(]].](((((....)))))..))))))))). Crystal structure of the SAM-I riboswitch A94G U34 G18U G19U variant in complex with SAM; SAM-I RIBOSWITCH 2yie X 54 2.941 RF00050 URS000080E295_190304 21745821 0010181 190304 ngaucuucggggcagggugaaauucccgaccggugguauaguccacgaauccau ..............<<<.......>>>.....<<<<......>>>>........ ..............(((.......))).....((((......))))........ Crystal structure of a F. nucleatum FMN riboswitch bound to FMN; FMN RIBOSWITCH 2yie Z 57 2.941 RF00050 URS000080E334_190304 21745821 0010181 190304 ngauugauuuggugaaauuccaaaaccgacaguagagucuggaugagagaagauucg .......<<<<<.......>>>>>.....<<<......>>>................ .......(((((.......))))).....(((......)))................ Crystal structure of a F. nucleatum FMN riboswitch bound to FMN; FMN RIBOSWITCH 2yif X 53 3.298 RF00050 URS000080E295_190304 21745821 0010181 190304 ngaucuucggggcagggugaaauucccgaccggugguauaguccacgaaucca ..............<<<.......>>>.....<<<<......>>>>....... ..............(((.......))).....((((......))))....... Crystal structure of a F. nucleatum FMN riboswitch - Free state; FMN RIBOSWITCH 2yif Z 57 3.298 RF00050 URS000080E334_190304 21745821 0010181 190304 ngauugauuuggugaaauuccaaaaccgacaguagagucuggaugagagaagauucg .......<<<<<.......>>>>>.....<<<......>>>................ .......(((((.......))))).....(((......)))................ Crystal structure of a F. nucleatum FMN riboswitch - Free state; FMN RIBOSWITCH 2ykg C 10 2.5 URS000080DF81_9606 22000018 9606 gcgcgcgcgc .......... .......... Structural insights into RNA recognition by RIG-I; 5'-R(*GP*CP*GP*CP*GP*CP*GP*CP*GP*CP)-3' 2ykg D 10 2.5 URS000080DF81_9606 22000018 9606 gcgcgcgcgc .......... .......... Structural insights into RNA recognition by RIG-I; 5'-R(*GP*CP*GP*CP*GP*CP*GP*CP*GP*CP)-3' 2z74 A 21 2.2 URS000080E125_119072 17804015 119072 agcgccuggacuuaaagccau ..................... ..................... T. tengcongensis glmS ribozyme bound to glucose-6-phosphate; glmS ribozyme substrate RNA 2z74 B 123 2.2 RF00234 URS000080DF18_119072 17804015 0003824 0010468 119072 ggcuuuaaguugacgagggcaggguuuaucgagacaucggcgggugcccugcggucuuccugcgaccguuagaggacugguaaaaccacaggcgacuguggcauagagcaguccgggcaggaa .............(((...<<<<<<...)))..............>>>>>>(((((.<<<<<<))))).....<<<<<<......<<<<<<....>>>>>>.......>>>>>>..>>>>>>. .............[[[...((((((...]]]..............))))))[[[[[.((((((]]]]].....((((((......((((((....)))))).......))))))..)))))). T. tengcongensis glmS ribozyme bound to glucose-6-phosphate; glmS ribozyme RNA 2z75 A 21 1.7 URS000080E125_273068 17804015 273068 agcgccuggacuuaaagccau ..................... ..................... T. tengcongensis glmS ribozyme bound to glucosamine-6-phosphate; glmS ribozyme substrate RNA 2z75 B 123 1.7 RF00234 URS000080DF18_273068 17804015 0003824 0010468 273068 ggcuuuaaguugacgagggcaggguuuaucgagacaucggcgggugcccugcggucuuccugcgaccguuagaggacugguaaaaccacaggcgacuguggcauagagcaguccgggcaggaa .............(((...<<<<<<...)))..............>>>>>>(((((.<<<<<<))))).....<<<<<<......<<<<<<....>>>>>>.......>>>>>>..>>>>>>. .............[[[...((((((...]]]..............))))))[[[[[.((((((]]]]].....((((((......((((((....)))))).......))))))..)))))). T. tengcongensis glmS ribozyme bound to glucosamine-6-phosphate; glmS ribozyme RNA 2zi0 C 20 2.82 URS000080E31B_32630 18600235 32630 agacagcauuaugcugucuu .................... .................... Crystal structure of Tav2b/siRNA complex; RNA (5'-D(P*AP*GP*AP*CP*AP*GP*CP*AP*UP*UP*AP*UP*GP*CP*UP*GP*UP*CP*UP*UP*U)-3') 2zi0 D 20 2.82 URS000080E31B_32630 18600235 32630 agacagcauuaugcugucuu .................... .................... Crystal structure of Tav2b/siRNA complex; RNA (5'-D(P*AP*GP*AP*CP*AP*GP*CP*AP*UP*UP*AP*UP*GP*CP*UP*GP*UP*CP*UP*UP*U)-3') 2zjp X 2686 3.7 RF02540,RF02541 URS000080DEF1_1299 18406324 0003735 0005840 1299 ggucaagauaguaaggguccacgguggaugcccuggcgcuggagccgaugaaggacgcgauuaccugcgaaaagccccgacgagcuggagauacgcuuugacucggggauguccgaauggggaaacccaccucguaagagguauccgcaaggaugggaacucagggaacugaaacaucucaguaccugaaggagaagaaagagaauucgauuccguuaguagcggcgagcgaacccggaucagcccaaucaagccgaaguggcuggaaagcuacaccucagaaggugagaguccuguaggcgaacgagaggucguuguucgugaaacgaugacugaauccgcgcggaccaccgcgcaaggcuaaauacucccagugaccgauagcgcauaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaagagaaccugaaaccguggacuuacaagcagucauggcaccuuaugcguguuauggcgugccuauugaagcaugagccggcgacuuagaccugacgugcgagcuuaaguugaaaaacggaggcggagcgaaagcgaguccgaauagggcggcauuaguacgucgggcuagacucgaaaccaggugagcuaagcaugaccagguugaaacccccgugacagggggcggaggaccgaaccggugccugcugaaacagucucggaugaguuguguuuaggagugaaaagcuaaccgaaccuggagauagcuaguucuccccgaaauguauugagguacagccucggauguugaccauguccuguagagcacucacaaggcuaaaaccuuaugaaacuccgaaggggcacgcguuuaguccgggagugaggcugcgagagcuaacuuccguagccgagagggaaacaacccagaccaucagcuaaggucccuaaaugaucgcucagugguuaaggaugugucgucgcauagacagccaggagguuggcuuagaagcagccacccuucaaagagugcguaauagcucacuggucgagugacgaugcgccgaaaaugaucggggcucaagugaucuaccgaagcuauggauucaacucgcgaagcgaguugucugguaggggagcguucaguccgcggagaagccauaccggaaggagugguggagccgacugaagugcggaugccggcaugaguaacgauaaaagaagugagaaucuucuucgccguaaggacaaggguuccuggggaagggucguccgcccagggaaagucgggaccuaaggugaggccgaacggcgcagccgauggacagcaggucaagauuccugcaccgaucauguggagugauggagggacgcauuacgcuauccaaugccaagcuauggcuaugcugguugguacgcucaagggcgaucgggucagaaaaucuaccggucacaugccucagacguaucgggagcuuccucggaagcgaaguuggaaacgcgacggugccaagaaaagcuucuaaacguugaaacaugauugcccguaccgcaaaccgacacagguguccgagugucaaugcacuaaggcgcgcgagagaacccucguuaaggaacuuugcaaucucaccccguaacuucggaagaagggguccccacgcuucgcguggggcgcagugaauaggcccaggcgacuguuuaccaaaaucacagcacucugccaacacgaacaguggacguauagggugugacgccugcccggugccggaaggucaaguggagcggugcaagcugcgaaaugaagccccggugaacggcuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaggcguaacgaucugggcgcugucucaacgagggacucggugaaauugaauuggcuguaaagaugcggccuacccguagcaggacgaaaagaccccguggagcuuuacuauagucuggcauugggauucggguuucuagaaacuuggauuucuaaccugaaaaaucacuuucggggaccgugcuuggcggguaguuugacuggggcggucgccucccaaaauguaacggaggcgcccaaaggucaccucaagacgguuggaaaucgucuguagagcgcaaagguagaagguggcuugacugcgagacugacacgucgagcagggaggaaacucgggcuuagugaaccggugguaccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagaguccauaucggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgcuacgggcgcaggagaauugaggggaguugcuccuaguacgagaggaccggagugaacggaccgcuggucucccugcugucguaccaacggcacaugcaggguagcuauguccggaacggauaaccgcugaaagcaucuaagcgggaagccagccccaagaugaguucucccacuguuuaucagguaagacucccggaagaccaccggguuaagaggccaggcgugcacgcauagcaauguguucagcggacuggugcucaucagucgaggucuugacca <<<<<<<<......<<<<<<<<<<<....<<<..<<<<<<<<<<<<......<<<<<<<((..((>>>>.....<<<<<<...<<.))..))..>>......>>>>>>...>>>....<<<....>>><<<<<....>>>>><<<<....>>>>>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<......<<.....>>.....>>>>...<<<...<<..<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>....>>..<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>..............<<....>>....>>.........<<<<....>>>>.............>....>>>>>>>>>>>.......<<<<<<<<<<.......>>>>>>>>>>...<............>.<<<<<<....<<<.<<<<<<<<<<..<<<...<<<....>>>...>>>...<<....>>...<........>.........>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<.....<<<<<......>>>>>......>>>...<<<<.<.<<........>>.>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<...<<<<.<<<<<<...<<<...<<<.<<<<......>>>>.>>>..>>.>...>>>>>>.>.>>>..>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<......<.<<<<<.<<<..<<<<.......>>>>..>>>.........<<......>>...>>>>>.>..>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><..<<<<<<<<...>>>>>>>>..>....>>>>>><.<<<<<<<.<<......<<<<<.<<....>>.>>>>>...>>.>>>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<<..>>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<...<<...<<<<....<<<<..<<<..<<<<<.<<<<.<<...[[....>>>>>><<<<<<<.<<..<<<<<<<<<<...<<.....>>.>>>>>>....>>>>..>>>>>>>>>...<<<<<....>>>>>....>>>>>...>>>...>>>>.........>>>>...>>......>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<...>>>>>>>>............<<<<<<<<<..<<...........>>..<<<<<<<.....<<<.....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>>.......<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<>>>>>>>>>>>>>>>...<<<<<<........>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<.<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>..>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.]].>>>>>>...>>>>>...>>>>.>>>>>....<<....<<<<<...........>>>>>....>>..>>>>.......>>>>>>>..<<.......>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>>>. ((((((((......((((((((((.....(((..(((.((((((((......((((((.[[..[[.))).....((((((...((.]]..]]..))......))))))...)))....(((....)))(((((....)))))((((....))))))...((((((.....((....))......))))).).........((....))...((((......((.....)).....))))...(((...((..(((...(((((......)))))[[(...).(((.....]])))...)))....))..(((((((((.[.....)))))))))......(((((].[[[[)))))..)))......)).)))).).))..............((....))....))......(..((((....))))............)).....)))))))))).....(.((((((((((.......)))))))))).[.(.(........).).((((((....(((.((((((((((..(((...(((....)))...)))...((....))...((......)).........)))))))))))))..((.(...((((((.....((((((((((.((((....(((((......)))))....)[)))...(((..(.((........)).).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))((((((((...(((((.((((((.(.(((...(((.((((......)))).)))..)).)..))))))).).))).).)))))).))..(((((((.((......)).)))))))....(((......)))...((((.(((...((([[[...(.(((((((....(.....((..(.((((((((.....{.(((((.(((..(((.........)))..))).....(...((......)).).)))))...)))))))).).))..........]]].)..).))))))))))...)))))))(..((((((((...))))))))..)....))))))(.(((((((.((......(((((.((....)).)))))...)).)))))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((((((...((...((((....(((((.(((..(((((.((((.((...{{....))))))(((((((.((..((((((((((...((.....)).))))))....))))..)))))))))...(((((....)))))....)))))...)))..)))))(..).....))))...))......))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((...))))))))(...).......(((((((((.].(...........)...(((((((.....(((.....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..))))).......((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((()))))))))))))))...(((((((......)))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...)..(][.[[[).....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))....)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))....((....((((.....}.......))))....))..))))..]....)))))))(.((.......))....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))...))))))))). Thiopeptide antibiotic Nosiheptide bound to the large ribosomal subunit of Deinococcus radiodurans; RIBOSOMAL 23S RNA 2zjp Z 122 3.7 RF00001 URS000080E04E_1299 18406324 0003735 0005840 1299 cacccccgugcccauagcacuguggaaccaccccaccccaugccgaacugggucgugaaacacagcagcgccaaugauacucggaccgcagggucccggaaaagucggucagcgcggggguu .<<<<<<<<<<.....<<.<<<<<....<<<<<<<.............>>>>..>>>...>>>>>..>><<<.......<<.<<<<<....>>>>>.>>.......>>>..>>>>>>>>>>. .((((((((((.....((.(((((....(((((((...(.....)...))))..)))...)))))..)).((.......((.(((((....))))).)).......))...)))))))))). Thiopeptide antibiotic Nosiheptide bound to the large ribosomal subunit of Deinococcus radiodurans; RIBOSOMAL 5S RNA 2zjq X 2686 3.3 RF02540,RF02541 URS000080DEF1_1299 18406324 0003735 0005840 1299 ggucaagauaguaaggguccacgguggaugcccuggcgcuggagccgaugaaggacgcgauuaccugcgaaaagccccgacgagcuggagauacgcuuugacucggggauguccgaauggggaaacccaccucguaagagguauccgcaaggaugggaacucagggaacugaaacaucucaguaccugaaggagaagaaagagaauucgauuccguuaguagcggcgagcgaacccggaucagcccaaucaagccgaaguggcuggaaagcuacaccucagaaggugagaguccuguaggcgaacgagaggucguuguucgugaaacgaugacugaauccgcgcggaccaccgcgcaaggcuaaauacucccagugaccgauagcgcauaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaagagaaccugaaaccguggacuuacaagcagucauggcaccuuaugcguguuauggcgugccuauugaagcaugagccggcgacuuagaccugacgugcgagcuuaaguugaaaaacggaggcggagcgaaagcgaguccgaauagggcggcauuaguacgucgggcuagacucgaaaccaggugagcuaagcaugaccagguugaaacccccgugacagggggcggaggaccgaaccggugccugcugaaacagucucggaugaguuguguuuaggagugaaaagcuaaccgaaccuggagauagcuaguucuccccgaaauguauugagguacagccucggauguugaccauguccuguagagcacucacaaggcuaaaaccuuaugaaacuccgaaggggcacgcguuuaguccgggagugaggcugcgagagcuaacuuccguagccgagagggaaacaacccagaccaucagcuaaggucccuaaaugaucgcucagugguuaaggaugugucgucgcauagacagccaggagguuggcuuagaagcagccacccuucaaagagugcguaauagcucacuggucgagugacgaugcgccgaaaaugaucggggcucaagugaucuaccgaagcuauggauucaacucgcgaagcgaguugucugguaggggagcguucaguccgcggagaagccauaccggaaggagugguggagccgacugaagugcggaugccggcaugaguaacgauaaaagaagugagaaucuucuucgccguaaggacaaggguuccuggggaagggucguccgcccagggaaagucgggaccuaaggugaggccgaacggcgcagccgauggacagcaggucaagauuccugcaccgaucauguggagugauggagggacgcauuacgcuauccaaugccaagcuauggcuaugcugguugguacgcucaagggcgaucgggucagaaaaucuaccggucacaugccucagacguaucgggagcuuccucggaagcgaaguuggaaacgcgacggugccaagaaaagcuucuaaacguugaaacaugauugcccguaccgcaaaccgacacagguguccgagugucaaugcacuaaggcgcgcgagagaacccucguuaaggaacuuugcaaucucaccccguaacuucggaagaagggguccccacgcuucgcguggggcgcagugaauaggcccaggcgacuguuuaccaaaaucacagcacucugccaacacgaacaguggacguauagggugugacgccugcccggugccggaaggucaaguggagcggugcaagcugcgaaaugaagccccggugaacggcuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaggcguaacgaucugggcgcugucucaacgagggacucggugaaauugaauuggcuguaaagaugcggccuacccguagcaggacgaaaagaccccguggagcuuuacuauagucuggcauugggauucggguuucuagaaacuuggauuucuaaccugaaaaaucacuuucggggaccgugcuuggcggguaguuugacuggggcggucgccucccaaaauguaacggaggcgcccaaaggucaccucaagacgguuggaaaucgucuguagagcgcaaagguagaagguggcuugacugcgagacugacacgucgagcagggaggaaacucgggcuuagugaaccggugguaccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagaguccauaucggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgcuacgggcgcaggagaauugaggggaguugcuccuaguacgagaggaccggagugaacggaccgcuggucucccugcugucguaccaacggcacaugcaggguagcuauguccggaacggauaaccgcugaaagcaucuaagcgggaagccagccccaagaugaguucucccacuguuuaucagguaagacucccggaagaccaccggguuaagaggccaggcgugcacgcauagcaauguguucagcggacuggugcucaucagucgaggucuugacca <<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<<((..((>>>>.....<<<<<<...<<.))..))..>>......>>>>>>...>>>....<<<....>>><<<<<....>>>>><<<<....>>>>>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<......<<.....>>.....>>>>...<<<...<<..<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>....>>..<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>..............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<.......>>>>>>>>>>...<.<........>.>.<<<<<<....<<<.<<<<<<<<<<..<<<...<<<....>>>...>>>...<<....>>...<<......>>.........>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<.....<<<<<......>>>>>......>>>...<<<<.<.<<........>>.>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<...<<<<.<<<<<<...<<<...<<<.<<<<......>>>>.>>>..>>.>...>>>>>>.>.>>>..>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<......<.<<<<<.<<<..<<<<.......>>>>..>>>.........<<......>>...>>>>>.>..>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><..<<<<<<<<...>>>>>>>>..>....>>>>>><.<<<<<<<.<<......<<<<<.<<....>>.>>>>>...>>.>>>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<<..>>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<...<<...<<<<....<<<<..<<<..<<<<<.<<<<.<<...[[....>>>>>><<<<<<<.<<..<<<<<<<<<<...<<.....>>.>>>>>>....>>>>..>>>>>>>>>...<<<<<....>>>>>....>>>>>...>>>...>>>>.........>>>>...>>......>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<...>>>>>>>>............<<<<<<<<<..<<...........>>..<<<<<<<.....<<<.....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>>.......<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<>>>>>>>>>>>>>>>...<<<<<<........>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.]].>>>>>>...>>>>>...>>>>.>>>>>....<<....<<<<<...........>>>>>....>>..>>>>.......>>>>>>>..<<.......>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>>>. ((((((((......((((((((((.....(((..(((.((((((((......((((((.[[..[[.))).....((((((...((.]]..]]..))......))))))...)))....(((....)))(((((....)))))((((....))))))...((((((.....((....))......))))).).........((....))...((((......((.....)).....))))...(((...((..(((...(((((......)))))[[(...).(((.....]])))...)))....))..(((((((((.[.....)))))))))......(((((].[[[[)))))..)))......)).)))).).))..............((....))....))......(..((((....))))............)).....)))))))))).....(.((((((((((.......)))))))))).[.(.(........).).((((((....(((.((((((((((..(((...(((....)))...)))...((....))...((......)).........)))))))))))))..((.(...((((((.....((((((((((.((((....(((((......)))))....)[)))...(((..(.((........)).).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((..(((((.((((((.(.(((...(((.((((......)))).)))..)).)..))))))).).))).)))))))).))..(((((((.((......)).)))))))....(((......)))...((((.(((...((([[[...(.(((((((....(.....((..((((((((.(.....{..((((.(((..(((.........)))..))).....(...((......)).).))))....).)))))))).))..........]]].)..).))))))))))...)))))))(..((((((((...))))))))..)....))))))(.(((((((.((......(((((.((....)).)))))...)).)))))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((((((...((...((((....(((((.(((..(((((.((((.((...{{....))))))(((((((.((..((((((((((...((.....)).))))))....))))..)))))))))...(((((....)))))....)))))...)))..)))))(..).....))))...))......))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((...))))))))(...).......(((((((((.].(...........)...(((((((.....(((.....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..))))).......((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((.((((((())))))).)))))))...(((((((......)))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...)..(][.[[[).....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))....)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))....((....((((.....}.......))))....))..))))..]....)))))))(.((.......))....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))...))))))))). Interaction of L7 with L11 induced by Microccocin binding to the Deinococcus radiodurans 50S subunit; ribosomal 23S RNA 2zjq Y 122 3.3 RF00001 URS000080E31C_1299 18406324 0003735 0005840 1299 cacccccgugcccauagcacuguggaaccaccccaccccaugccgaacugggucgugaaacacagcagcgccaaugauacucggaccgcagggucccggaaaagucggucagcgcggggguu .<<<<<<<<<<.....<<.<<<<<....<<<<<<<.............>>>>..>>>...>>>>>..>><<<.......<<.<<<<<....>>>>>.>>.......>>>..>>>>>>>>>>. .((((((((((.....((.(((((....(((((((...(.....)...))))..)))...)))))..))(((.......((.(((((....))))).)).......)))..)))))))))). Interaction of L7 with L11 induced by Microccocin binding to the Deinococcus radiodurans 50S subunit; ribosomal 5S RNA 2zjr X 2686 2.91 RF02540,RF02541 URS000080DEF1_1299 18406324 0003735 0005840 1299 ggucaagauaguaaggguccacgguggaugcccuggcgcuggagccgaugaaggacgcgauuaccugcgaaaagccccgacgagcuggagauacgcuuugacucggggauguccgaauggggaaacccaccucguaagagguauccgcaaggaugggaacucagggaacugaaacaucucaguaccugaaggagaagaaagagaauucgauuccguuaguagcggcgagcgaacccggaucagcccaaucaagccgaaguggcuggaaagcuacaccucagaaggugagaguccuguaggcgaacgagaggucguuguucgugaaacgaugacugaauccgcgcggaccaccgcgcaaggcuaaauacucccagugaccgauagcgcauaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaagagaaccugaaaccguggacuuacaagcagucauggcaccuuaugcguguuauggcgugccuauugaagcaugagccggcgacuuagaccugacgugcgagcuuaaguugaaaaacggaggcggagcgaaagcgaguccgaauagggcggcauuaguacgucgggcuagacucgaaaccaggugagcuaagcaugaccagguugaaacccccgugacagggggcggaggaccgaaccggugccugcugaaacagucucggaugaguuguguuuaggagugaaaagcuaaccgaaccuggagauagcuaguucuccccgaaauguauugagguacagccucggauguugaccauguccuguagagcacucacaaggcuaaaaccuuaugaaacuccgaaggggcacgcguuuaguccgggagugaggcugcgagagcuaacuuccguagccgagagggaaacaacccagaccaucagcuaaggucccuaaaugaucgcucagugguuaaggaugugucgucgcauagacagccaggagguuggcuuagaagcagccacccuucaaagagugcguaauagcucacuggucgagugacgaugcgccgaaaaugaucggggcucaagugaucuaccgaagcuauggauucaacucgcgaagcgaguugucugguaggggagcguucaguccgcggagaagccauaccggaaggagugguggagccgacugaagugcggaugccggcaugaguaacgauaaaagaagugagaaucuucuucgccguaaggacaaggguuccuggggaagggucguccgcccagggaaagucgggaccuaaggugaggccgaacggcgcagccgauggacagcaggucaagauuccugcaccgaucauguggagugauggagggacgcauuacgcuauccaaugccaagcuauggcuaugcugguugguacgcucaagggcgaucgggucagaaaaucuaccggucacaugccucagacguaucgggagcuuccucggaagcgaaguuggaaacgcgacggugccaagaaaagcuucuaaacguugaaacaugauugcccguaccgcaaaccgacacagguguccgagugucaaugcacuaaggcgcgcgagagaacccucguuaaggaacuuugcaaucucaccccguaacuucggaagaagggguccccacgcuucgcguggggcgcagugaauaggcccaggcgacuguuuaccaaaaucacagcacucugccaacacgaacaguggacguauagggugugacgccugcccggugccggaaggucaaguggagcggugcaagcugcgaaaugaagccccggugaacggcuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaggcguaacgaucugggcgcugucucaacgagggacucggugaaauugaauuggcuguaaagaugcggccuacccguagcaggacgaaaagaccccguggagcuuuacuauagucuggcauugggauucggguuucuagaaacuuggauuucuaaccugaaaaaucacuuucggggaccgugcuuggcggguaguuugacuggggcggucgccucccaaaauguaacggaggcgcccaaaggucaccucaagacgguuggaaaucgucuguagagcgcaaagguagaagguggcuugacugcgagacugacacgucgagcagggaggaaacucgggcuuagugaaccggugguaccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagaguccauaucggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgcuacgggcgcaggagaauugaggggaguugcuccuaguacgagaggaccggagugaacggaccgcuggucucccugcugucguaccaacggcacaugcaggguagcuauguccggaacggauaaccgcugaaagcaucuaagcgggaagccagccccaagaugaguucucccacuguuuaucagguaagacucccggaagaccaccggguuaagaggccaggcgugcacgcauagcaauguguucagcggacuggugcucaucagucgaggucuugacca <<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<<((..((>>>>.....<<<<<<...<<.))..))..>>......>>>>>>...>>>....<<<....>>><<<<<....>>>>><<<<....>>>>>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<......<<.....>>.....>>>>...<<<...<<..<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>....>>..<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>..............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<.......>>>>>>>>>>...<.<........>.>.<<<<<<....<<<.<<<<<<<<<<..<<<...<<<....>>>...>>>...<<....>>...<<......>>.........>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<.....<<<<<......>>>>>......>>>...<<<<.<.<<........>>.>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<...<<<<.<<<<<<...<<<...<<<.<<<<......>>>>.>>>..>>.>...>>>>>>.>.>>>..>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><..<<<<<<<<...>>>>>>>>..>....>>>>>><.<<<<<<<.<<......<<<<<.<<....>>.>>>>>...>>.>>>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<<..>>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<...<<...<<<<....<<<<..<<<..<<<<<.<<<<.<<...[[....>>>>>><<<<<<<.<<..<<<<<<<<<<...<<.....>>.>>>>>>....>>>>..>>>>>>>>>...<<<<<....>>>>>....>>>>>...>>>...>>>>.........>>>>...>>......>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<<<<<<<...>>>>>>>>............<<<<<<<<<..<<...........>>..<<<<<<<.....<<<.....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>>.......<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<>>>>>>>>>>>>>>>...<<<<<<........>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.]].>>>>>>...>>>>>...>>>>.>>>>>....<<....<<<<<...........>>>>>....>>..>>>>.......>>>>>>>..<<.......>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>>>. ((((((((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...((.]]..]]..))......))))))...)))....(((....)))(((((....)))))((((....))))))...((((((.....(...[..)......))))).).........((....))...((((......((.]...)).....))))...(((...((..(((...(((((......)))))[[(...).(((.....]])))...)))....))..(((((((((.[.....)))))))))......(((((].[[[[)))))..)))......)).)))))).))..............((....))....))......(..((((....))))............)).....)))))))))).....(.((((((((((.......)))))))))).[.(.(........).).((((((....(((.((((((((((..(((...(((....)))...)))...((....))...((......)).........)))))))))))))..((.(...((((((.....((((((((((.((((....(((((......)))))....)[)))...(((..(.((........)).).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((..(((((.((((((...(((...(((.((((......)))).)))..)).)...)))))).).))).)))))))).))..(((((((.((......)).)))))))....(((......)))...((((.(((...((([[[...(.(((((((....(.....((..((((((((.(.....{.(((((.(((..(((.........)))..))).....(...((......)).).)))))...).)))))))).))..........]]].)..).))))))))))...)))))))(..((((((((...))))))))..)....))))))(.(((((((.((......(((((.((....)).)))))...)).)))))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((((((...((...((((....(((((.(((..(((((.((((.((...{{....))))))(((((((.((..((((((((((...((.....)).))))))....))))..)))))))))...(((((....)))))....)))))...)))..)))))(..).....))))...))......))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((...))))))))(...).......(((((((((.].(...........)...(((((((.....(((.....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..))))).......((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((.((((((())))))).)))))))...(((((((......)))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))....)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))....((....((((.....}.......))))....))..))))..]....)))))))(.((.......))....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))...))))))))). Refined native structure of the large ribosomal subunit (50S) from Deinococcus radiodurans; ribosomal 23S RNA 2zjr Y 122 2.91 RF00001 URS000080E04E_1299 18406324 0003735 0005840 1299 cacccccgugcccauagcacuguggaaccaccccaccccaugccgaacugggucgugaaacacagcagcgccaaugauacucggaccgcagggucccggaaaagucggucagcgcggggguu .<<<<<<<<<<.....<<.<<<<<....<<<<<<<.............>>>>..>>>...>>>>>..>><<<.......<<.<<<<<....>>>>>.>>.......>>>..>>>>>>>>>>. .((((((((((.....((.(((((....(((((((...(.....)...))))..)))...)))))..)).((.......((.(((((....))))).)).......))...)))))))))). Refined native structure of the large ribosomal subunit (50S) from Deinococcus radiodurans; ribosomal 5S RNA 2zko C 21 1.7 URS000080E31B_32630 18813227 32630 agacagcauuaugcugucuuu ..................... ..................... Structural basis for dsRNA recognition by NS1 protein of human influenza virus A; RNA (5'-R(P*AP*GP*AP*CP*AP*GP*CP*AP*UP*UP*AP*UP*GP*CP*UP*GP*UP*CP*UP*UP*U)-3') 2zko D 21 1.7 URS000080E31B_32630 18813227 32630 agacagcauuaugcugucuuu ..................... ..................... Structural basis for dsRNA recognition by NS1 protein of human influenza virus A; RNA (5'-R(P*AP*GP*AP*CP*AP*GP*CP*AP*UP*UP*AP*UP*GP*CP*UP*GP*UP*CP*UP*UP*U)-3') 300d A 16 3.0 URS000080DF69_32630 8953035 32630 guggucugaugaggcc ................ ................ CAPTURING THE STRUCTURE OF A CATALYTIC RNA INTERMEDIATE: RNA HAMMERHEAD RIBOZYME, MN(II)-SOAKED; RNA HAMMERHEAD RIBOZYME 300d B 25 3.0 URS000080E0D1_32630 8953035 32630 ggccgaaacucguaagagucaccac ........<<<....>>>....... .......((((....))))...... CAPTURING THE STRUCTURE OF A CATALYTIC RNA INTERMEDIATE: RNA HAMMERHEAD RIBOZYME, MN(II)-SOAKED; RNA HAMMERHEAD RIBOZYME 301d A 16 3.0 URS000080DF69_32630 8953035 32630 guggucugaugaggcc ................ ................ CAPTURING THE STRUCTURE OF A CATALYTIC RNA INTERMEDIATE: RNA HAMMERHEAD RIBOZYME, MG(II)-SOAKED; RNA HAMMERHEAD RIBOZYME 301d B 25 3.0 URS000080E0D1_32630 8953035 32630 ggccgaaacucguaagagucaccac ........<<<....>>>....... .......((((....))))...... CAPTURING THE STRUCTURE OF A CATALYTIC RNA INTERMEDIATE: RNA HAMMERHEAD RIBOZYME, MG(II)-SOAKED; RNA HAMMERHEAD RIBOZYME 353d A 12 2.4 URS000080E2AA_32630 8082756 32630 aucccccgugcc ............ ............ CRYSTAL STRUCTURE OF DOMAIN A OF THERMUS FLAVUS 5S RRNA AND THE CONTRIBUTION OF WATER MOLECULES TO ITS STRUCTURE; RNA (5'-R(*AP*UP*CP*CP*CP*CP*CP*GP*UP*GP*CP*C)-3') 353d B 12 2.4 URS000080E33A_32630 8082756 32630 ggugcgggggau ............ ............ CRYSTAL STRUCTURE OF DOMAIN A OF THERMUS FLAVUS 5S RRNA AND THE CONTRIBUTION OF WATER MOLECULES TO ITS STRUCTURE; RNA (5'-R(*GP*GP*UP*GP*CP*GP*GP*GP*GP*GP*AP*U)-3') 354d A 12 1.5 URS000080E2D8_562 9393863 562 ccgaugguagug ............ ............ Structure of loop E FROM E. coli 5S RRNA; RNA (5'-R(*CP*CP*GP*AP*UP*GP*GP*UP*AP*GP*UP*G)-3') 354d B 12 1.5 URS000080E18B_562 9393863 562 gcgagaguagnc ............ ............ Structure of loop E FROM E. coli 5S RRNA; RNA-DNA (5'-R(*GP*CP*GP*AP*GP*AP*GP*UP*AP*)-D(*DGP(S)*)-R(*GP*C)-3') 357d A 11 3.5 URS000080E0CA_562 9393863 562 ugccnggcggc ........... ........... 3.5 A structure of fragment I from E. coli 5S RRNA; RNA-DNA (5'-R(*UP*GP*DCP)-D(*CP(S)*)-R(*UP*GP*GP*CP*GP*GP*C)-3') 357d B 19 3.5 URS000080E1DA_562 9393863 562 ccgaugguagugugggguc ................... ................... 3.5 A structure of fragment I from E. coli 5S RRNA; RNA (5'-R(*CP*CP*GP*AP*UP*GP*GP*UP*AP*GP*UP*GP*UP*GP*GP*GP*G*UP*C)-3') 357d C 31 3.5 URS000080E225_562 9393863 562 ccccaugcgagaguagggaacugccaggcau ............................... ............................... 3.5 A structure of fragment I from E. coli 5S RRNA; RNA (5'-R(*CP*CP*CP*CP*AP*UP*GP*CP*GP*AP*GP*AP*GP*UP*AP*GP*G P*GP*AP*AP*CP*UP* GP*CP*CP*AP*GP*GP*CP*AP*U)-3') 359d A 16 2.9 URS000080DF69_32630 9417029,8953035 32630 guggucugaugaggcc ................ ................ INHIBITION OF THE HAMMERHEAD RIBOZYME CLEAVAGE REACTION BY SITE-SPECIFIC BINDING OF TB(III); RNA HAMMERHEAD RIBOZYME 359d B 25 2.9 URS000080E0D1_32630 9417029,8953035 32630 ggccgaaacucguaagagucaccac ........<<<....>>>....... .......((((....))))...... INHIBITION OF THE HAMMERHEAD RIBOZYME CLEAVAGE REACTION BY SITE-SPECIFIC BINDING OF TB(III); RNA HAMMERHEAD RIBOZYME 364d A 11 3.0 URS000080E0CA_562 9393863 562 ugcnuggcggc ........... ........... 3.0 A STRUCTURE OF FRAGMENT I FROM E. COLI 5S RRNA; RNA (5'-R(*UP*GP*)-D(*(1SC)P*)-R(*CP*UP*GP*GP*CP*GP*GP*C)-3') 364d B 19 3.0 URS000080E1DA_562 9393863 562 ccgaugguagugugggguc ................... ................... 3.0 A STRUCTURE OF FRAGMENT I FROM E. COLI 5S RRNA; RNA (5'-R(*CP*CP*GP*AP*UP*GP*GP*UP*AP*GP*UP*GP*UP*GP*GP*GP*G *UP*C)-3') 364d C 31 3.0 URS000080E225_562 9393863 562 ccccaugcgagaguagggaacugccaggcau ............................... ............................... 3.0 A STRUCTURE OF FRAGMENT I FROM E. COLI 5S RRNA; RNA (5'-R(*CP*CP*CP*CP*AP*UP*GP*CP*GP*AP*GP*AP*GP*UP*AP*GP*G P*GP*AP*AP*CP*UP*GP*CP*CP*AP*GP*GP*CP*AP*U)-3') 379d A 16 3.1 URS000080DF69_32630 9506521 32630 guggucugaugaggcc ................ ................ THE STRUCTURAL BASIS OF HAMMERHEAD RIBOZYME SELF-CLEAVAGE; RNA (5'-R(*GP*UP*GP*GP*UP*CP*UP*GP*AP*UP*GP*AP*GP*GP*CP*C)-3') 379d B 25 3.1 URS000080E0D1_32630 9506521 32630 ggccgaaacucguaagagucaccac .......<<<<....>>>>...... ........(((....)))....... THE STRUCTURAL BASIS OF HAMMERHEAD RIBOZYME SELF-CLEAVAGE; RNA (5'-R(*GP*GP*CP*CP*GP*AP*AP*AP*CP*UP*CP*GP*UP*AP*AP*GP*A P*GP*UP*CP*AP*CP*CP*AP*C)-3') 397d A 15 1.3 URS000080DED6_32630 9707559 32630 ggccagaucugagcg ............... ............... A 1.3 A RESOLUTION CRYSTAL STRUCTURE OF THE HIV-1 TRANS-ACTIVATION RESPONSE REGION RNA STEM REVEALS A METAL ION-DEPENDENT BULGE CONFORMATION; RNA (5'-R(*GP*GP*CP*CP*AP*GP*AP*UP*CP*UP*GP*AP*GP*CP*G)-3') 397d B 12 1.3 URS000080E057_32630 9707559 32630 gcucucuggccc ............ ............ A 1.3 A RESOLUTION CRYSTAL STRUCTURE OF THE HIV-1 TRANS-ACTIVATION RESPONSE REGION RNA STEM REVEALS A METAL ION-DEPENDENT BULGE CONFORMATION; RNA (5'-R(*GP*CP*UP*CP*UP*CP*UP*GP*GP*CP*CP*C)-3') 3a6p D 22 2.92 URS000080E2FD_32630 19965479 32630 gguaaacauccgacuggaagcu ...................... ...................... Crystal structure of Exportin-5:RanGTP:pre-miRNA complex; pre-microRNA 3a6p E 24 2.92 URS000080E376_32630 19965479 32630 ggcuuucagucggauguuugccgc ........................ ........................ Crystal structure of Exportin-5:RanGTP:pre-miRNA complex; pre-microRNA 3a6p I 22 2.92 URS000080E2FD_32630 19965479 32630 gguaaacauccgacuggaagcu ...................... ...................... Crystal structure of Exportin-5:RanGTP:pre-miRNA complex; pre-microRNA 3a6p J 24 2.92 URS000080E376_32630 19965479 32630 ggcuuucagucggauguuugccgc ........................ ........................ Crystal structure of Exportin-5:RanGTP:pre-miRNA complex; pre-microRNA 3adi D 10 3.2 URS000080E285_32630 20462493 32630 cucgauaacc .......... .......... Structure of Arabidopsis HYL1 and its molecular implications for miRNA processing; RNA (5'-R(P*CP*UP*CP*GP*AP*UP*AP*AP*CP*C)-3') 3adi E 10 3.2 URS000080DD4D_32630 20462493 32630 gguuaucgag .......... .......... Structure of Arabidopsis HYL1 and its molecular implications for miRNA processing; RNA (5'-R(*GP*GP*UP*UP*AP*UP*CP*GP*AP*G)-3') 3adl B 10 2.2 URS000080DDD4_32630 20462493 32630 cgcgcgcgcg .......... .......... Structure of TRBP2 and its molecule implications for miRNA processing; RNA (5'-R(P*CP*GP*CP*GP*CP*GP*CP*GP*CP*G)-3') 3adl C 10 2.2 URS000080DDD4_32630 20462493 32630 cgcgcgcgcg .......... .......... Structure of TRBP2 and its molecule implications for miRNA processing; RNA (5'-R(P*CP*GP*CP*GP*CP*GP*CP*GP*CP*G)-3') 3avv T 11 3.119 URS000080DE7F_32630 22245970 32630 cgauggaccca ........... ........... Structure of viral RNA polymerase complex 3; RNA (5'-R(*AP*AP*CP*GP*AP*UP*GP*GP*AP*CP*CP*CP*A)-3') 3avw T 12 2.602 URS000080E063_32630 22245970 32630 aucguggaccca ............ ............ Structure of viral RNA polymerase complex 4; RNA (5'-R(*AP*UP*CP*GP*UP*GP*GP*AP*CP*CP*CP*A)-3') 3avx T 13 2.406 URS000080DE7F_32630 22245970 32630 aacgauggaccca ............. ............. Structure of viral RNA polymerase complex 5; RNA (5'-R(*AP*AP*CP*GP*AP*UP*GP*GP*AP*CP*CP*CP*A)-3') 3avy T 14 2.616 URS000080E273_32630 22245970 32630 acgauuuuauggac .............. .............. Structure of viral RNA polymerase complex 6; RNA (5'-R(*AP*AP*CP*GP*AP*UP*UP*UP*UP*AP*UP*GP*GP*AP*CP*CP*CP*A)-3') 3b31 A 29 2.4 URS000080DDC2_32630 18157151 32630 gguuauucagauuagguagucgaaugacc <<<<<<<<.<<<......>>>>>>>>>>> ((((((((.((........)))))))))) Crystal structure of domain III of the Cricket Paralysis Virus IRES RNA; RNA (29-MER) 3b31 B 14 2.4 URS000080E14D_32630 18157151 32630 uaagaaauuuaccu .............. .............. Crystal structure of domain III of the Cricket Paralysis Virus IRES RNA; RNA (5'-R(P*UP*AP*AP*GP*AP*AP*AP*UP*UP*UP*AP*CP*CP*U)-3') 3b4a A 22 2.7 URS000080DE3A_119072 17990888 119072 aagcgccuggacuuaaagccau ...................... ...................... T. tengcongensis glmS ribozyme with G40A mutation, bound to glucosamine-6-phosphate; glmS ribozyme substrate RNA 3b4a B 122 2.7 RF00234 URS000080E06F_119072 17990888 0003824 0010468 119072 ggcuuuaaguugacgagagcaggguuuaucgagacaucggcgggugcccugcggucuccugcgaccguuagaggacugguaaaaccacaggcgacuguggcauagagcaguccgggcaggan .............(((...<<<<<<...)))..............>>>>>>(((((<<<<<<))))).....<<<<<<......<<<<<<....>>>>>>.......>>>>>>..>>>>>>. .............[[[...((((((...]]]..............))))))[[[[[((((((]]]]].....((((((......((((((....)))))).......))))))..)))))). T. tengcongensis glmS ribozyme with G40A mutation, bound to glucosamine-6-phosphate; glmS ribozyme RNA 3b4b A 20 2.7 URS000080E25B_119072 17990888 119072 gcgccuggacuuaaagccau .................... .................... T. tengcongensis glmS ribozyme with G40A mutation, bound to glucosamine-6-phosphate and a substrate RNA with a 2'5'-phosphodiester linkage; glmS ribozyme substrate with 2'5'-phosphodiester linkage 3b4b B 123 2.7 RF00234 URS000080E06F_119072 17990888 0003824 0010468 119072 ggcuuuaaguugacgagagcaggguuuaucgagacaucggcgggugcccugcggucuuccugcgaccguuagaggacugguaaaaccacaggcgacuguggcauagagcaguccgggcaggaa .............(((...<<<<<<...)))..............>>>>>>(((((.<<<<<<))))).....<<<<<<......<<<<<<....>>>>>>.......>>>>>>..>>>>>>. .............[[[...((((((...]]]..............))))))[[[[[.((((((]]]]].....((((((......((((((....)))))).......))))))..)))))). T. tengcongensis glmS ribozyme with G40A mutation, bound to glucosamine-6-phosphate and a substrate RNA with a 2'5'-phosphodiester linkage; glmS ribozyme RNA 3b4c A 20 3.0 URS000080E25B_119072 17990888 119072 gcgccuggacuuaaagccau .................... .................... T. tengcongensis glmS ribozyme bound to glucosamine-6-phosphate and a substrate RNA with a 2'5'-phosphodiester linkage; glmS ribozyme substrate with a 2'5'-phosphodiester linkage 3b4c B 121 3.0 RF00234 URS000080DF18_119072 17990888 0003824 0010468 119072 ggcuuuaaguugacgagggcaggguuuaucgagacaucggcgggugcccugcggucuccugcgaccguuagaggacugguaaaaccacaggcgacuguggcauagagcaguccgggcagga .............(((...<<<<<<...)))..............>>>>>>((((..<<<<<.)))).....<<<<<<......<<<<<<....>>>>>>.......>>>>>>..>>>>>. .............[[[...((((((...]]]..............))))))[[[[..(((((.]]]].....((((((......((((((....)))))).......))))))..))))). T. tengcongensis glmS ribozyme bound to glucosamine-6-phosphate and a substrate RNA with a 2'5'-phosphodiester linkage; glmS ribozyme RNA 3b58 A 13 2.65 URS000080E09E_32630 18596253 32630 ucccaguccaccg ............. ............. Minimally Junctioned Hairpin Ribozyme Incorporates A38G Mutation and a 2',5'-Phosphodiester Linkage at the Active Site; Loop A Substrate strand 3b58 B 30 2.65 URS000080E2DF_32630 18596253 32630 cggugagaagggnggcagagaaacacacga .............................. .............................. Minimally Junctioned Hairpin Ribozyme Incorporates A38G Mutation and a 2',5'-Phosphodiester Linkage at the Active Site; 29-mer Loop A and Loop B Ribozyme strand 3b58 C 19 2.65 URS000080DE43_32630 18596253 32630 ucguggugcauuaccugcc ................... ................... Minimally Junctioned Hairpin Ribozyme Incorporates A38G Mutation and a 2',5'-Phosphodiester Linkage at the Active Site; Loop B S-turn strand 3b5a A 13 2.35 URS000080E09E_32630 18596253 32630 ucccnguccaccg ............. ............. Crystal Structure of a Minimally Hinged Hairpin Ribozyme Incorporating A38G mutation with a 2'OMe modification at the active site; Loop A Substrate strand 3b5a B 30 2.35 URS000080E2DF_32630 18596253 32630 cggugagaagggnggcagagaaacacacga .............................. .............................. Crystal Structure of a Minimally Hinged Hairpin Ribozyme Incorporating A38G mutation with a 2'OMe modification at the active site; 29-mer Loop A and Loop B Ribozyme strand 3b5a C 19 2.35 URS000080DE43_32630 18596253 32630 ucguggugcauuaccugcc ................... ................... Crystal Structure of a Minimally Hinged Hairpin Ribozyme Incorporating A38G mutation with a 2'OMe modification at the active site; Loop B S-turn strand 3b5f A 13 2.7 URS000080E09E_32630 18596253 32630 ucccaguccaccg ............. ............. Crystal Structure of a Minimally Hinged Hairpin Ribozyme Incorporating the Ade38Dap Mutation and a 2',5' Phosphodiester Linkage at the Active Site; Loop A Substrate strand 3b5f B 30 2.7 URS000080E2DF_32630 18596253 32630 cggugagaagggnggcagagaaacacacga .............................. .............................. Crystal Structure of a Minimally Hinged Hairpin Ribozyme Incorporating the Ade38Dap Mutation and a 2',5' Phosphodiester Linkage at the Active Site; 29-mer Loop A and Loop B Ribozyme strand 3b5f C 19 2.7 URS000080DE43_32630 18596253 32630 ucgugguncauuaccugcc ................... ................... Crystal Structure of a Minimally Hinged Hairpin Ribozyme Incorporating the Ade38Dap Mutation and a 2',5' Phosphodiester Linkage at the Active Site; Loop B S-turn strand 3b5s A 13 2.25 URS000080E09E_32630 18596253 32630 ucccnguccaccg ............. ............. Minimally Hinged Hairpin Ribozyme Incorporates A38DAP Mutation and 2'-O-methyl Modification at the Active Site; Loop A Substrate strand 3b5s B 30 2.25 URS000080E2DF_32630 18596253 32630 cggugagaagggnggcagagaaacacacga .............................. .............................. Minimally Hinged Hairpin Ribozyme Incorporates A38DAP Mutation and 2'-O-methyl Modification at the Active Site; 29-mer Loop A and Loop B Ribozyme strand 3b5s C 19 2.25 URS000080DE43_32630 18596253 32630 ucgugguncauuaccugcc ................... ................... Minimally Hinged Hairpin Ribozyme Incorporates A38DAP Mutation and 2'-O-methyl Modification at the Active Site; Loop B S-turn strand 3b91 A 13 2.75 URS000080E09E_32630 18596253 32630 ucccaguccaccg ............. ............. Minimally Hinged Hairpin Ribozyme Incorporates Ade38(2AP) and 2',5'-Phosphodiester Linkage Mutations at the Active Site; Loop A Substrate strand 3b91 B 30 2.75 URS000080E2DF_32630 18596253 32630 cggugagaagggnggcagagaaacacacga .............................. .............................. Minimally Hinged Hairpin Ribozyme Incorporates Ade38(2AP) and 2',5'-Phosphodiester Linkage Mutations at the Active Site; 29-mer Loop A and Loop B Ribozyme strand 3b91 C 19 2.75 URS000080E34C_32630 18596253 32630 ucgugguncauuaccugcc ................... ................... Minimally Hinged Hairpin Ribozyme Incorporates Ade38(2AP) and 2',5'-Phosphodiester Linkage Mutations at the Active Site; Loop B S-turn strand 3bbi A 13 2.35 URS000080E09E_32630 18596253 32630 ucccnguccaccg ............. ............. Minimally Junctioned Hairpin Ribozyme Incorporating A38(2AP) and A-1 2'-O-Me Modifications near Active Site; Loop A Substrate strand 3bbi B 30 2.35 URS000080E2DF_32630 18596253 32630 cggugagaagggnggcagagaaacacacga .............................. .............................. Minimally Junctioned Hairpin Ribozyme Incorporating A38(2AP) and A-1 2'-O-Me Modifications near Active Site; Loop A and Loop B Ribozyme strand 3bbi C 19 2.35 URS000080E34C_32630 18596253 32630 ucgugguncauuaccugcc ................... ................... Minimally Junctioned Hairpin Ribozyme Incorporating A38(2AP) and A-1 2'-O-Me Modifications near Active Site; Loop B S-turn strand 3bbk A 13 2.75 URS000080E09E_32630 18596253 32630 ucccaguccaccg ............. ............. Miminally Junctioned Hairpin Ribozyme Incorporates A38C and 2'5'-phosphodiester Linkage within Active Site; Loop A Substrate strand 3bbk B 30 2.75 URS000080E2DF_32630 18596253 32630 cggugagaagggnggcagagaaacacacga .............................. .............................. Miminally Junctioned Hairpin Ribozyme Incorporates A38C and 2'5'-phosphodiester Linkage within Active Site; Loop A and Loop B Ribozyme strand 3bbk C 19 2.75 URS000080DFE2_32630 18596253 32630 ucgugguccauuaccugcc ................... ................... Miminally Junctioned Hairpin Ribozyme Incorporates A38C and 2'5'-phosphodiester Linkage within Active Site; Loop B S-turn strand 3bbm A 13 2.65 URS000080E09E_32630 18596253 32630 ucccnguccaccg ............. ............. Minimally Junctioned Hairpin Ribozyme Incorporates A38C and 2'O-Me Modification at Active Site; Loop A Substrate strand 3bbm B 30 2.65 URS000080E2DF_32630 18596253 32630 cggugagaagggnggcagagaaacacacga .............................. .............................. Minimally Junctioned Hairpin Ribozyme Incorporates A38C and 2'O-Me Modification at Active Site; Loop A and Loop B Ribozyme strand 3bbm C 19 2.65 URS000080DFE2_32630 18596253 32630 ucgugguccauuaccugcc ................... ................... Minimally Junctioned Hairpin Ribozyme Incorporates A38C and 2'O-Me Modification at Active Site; Loop B S-turn strand 3bbx A 117 10.0 RF00001 URS0000049E57_562 19013177 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggc <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>> (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))) The Hsp15 protein fitted into the low resolution Cryo-EM map of the 50S.nc-tRNA.Hsp15 complex; 5S ribosomal RNA 3bbx B 2902 10.0 RF02540,RF02541 URS00004B0F34_562 19013177 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu .<<<.<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<......>>>>>..>>>......>>.>>>>>>>.>>...............<<....>>....>>.........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>..................<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.<...<<<...<<<.<<<<...<...<<.......>>...>...>>>>.>>>..>>.>...>.>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>>..............<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....[[....>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.......<<<<<..<<....>>...>>>>>.......>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.............<<<<<........>>>>>..<<<<<<<<.<<<.<<......<<<<.<<<<<<..<<<<<.<<<.<<<<..<<<<<<<<<<<.<<<<.........>.<<(.[..<<.......<<<<<<<<....>>>>>>>>....>>............>>).]...>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>.....>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<........>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.]].>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<<...>>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>.>>>.. .(...(((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(......)......))))).).........((....))...(((((.....((.....))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].....)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).......((((..(((((......)))))..))))..................((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...).)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((...(((((((((.(...(((...(((.((((.....[.((]......)).......)))).)))..)).)...).)))))).)))...))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.......(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))..............((((((.......))))))((((....((((..(....((((((...((.....)).))))))....[[(((..((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((............)))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).)))...).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(....).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((...((.........))...(((((((.....(((....))).......)))))))..((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).))))..........[..(((((......].)))))..((((((((.(((.((......((((.((((((..(((((.(((.((((..(((((((((((.((((.(.................(.......(((((((......)))))))....)..................).)))).)))))))))))...(((.((((((.....))))))))).....)))).)))..)))))..(((......[)))((((((..........]))))))..((...(((((((...(((((.........))))).....((.[.[[[))....)))))))...((((..((((....))))..)))).(((....))).))]]].].....(((((((.((........))))))))).............))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((....))))))..)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))..((((((...))))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..)..)))....). The Hsp15 protein fitted into the low resolution Cryo-EM map of the 50S.nc-tRNA.Hsp15 complex; 23S ribosomal RNA 3bnl A 22 2.602 URS000080E0C1_32630 18346970 32630 ugcgucacaccggugaagucgc ...................... ...................... Crystal structure of the bacterial ribosomal decoding A site in the presence of [Co(NH3)6]Cl3; A site of bacterial ribosome 3bnl B 22 2.602 URS000080E0C1_32630 18346970 32630 ugcgucacaccggugaagucgc ...................... ...................... Crystal structure of the bacterial ribosomal decoding A site in the presence of [Co(NH3)6]Cl3; A site of bacterial ribosome 3bnn A 21 2.0 URS000080E093_32630 18346970 32630 gcgucaccccggacaagucgc ..................... ..................... Crystal Structure of the Homo sapiens Mitochondrial Ribosomal Decoding Site; A site of human ribosome 3bnn B 21 2.0 URS000080E093_32630 18346970 32630 gcgucaccccggacaagucgc ..................... ..................... Crystal Structure of the Homo sapiens Mitochondrial Ribosomal Decoding Site; A site of human ribosome 3bnn C 21 2.0 URS000080E093_32630 18346970 32630 gcgucaccccggacaagucgc ..................... ..................... Crystal Structure of the Homo sapiens Mitochondrial Ribosomal Decoding Site; A site of human ribosome 3bnn D 21 2.0 URS000080E093_32630 18346970 32630 gcgucaccccggacaagucgc ..................... ..................... Crystal Structure of the Homo sapiens Mitochondrial Ribosomal Decoding Site; A site of human ribosome 3bno A 21 2.35 URS000080DD7E_32630 18346970 32630 gcgucaccncgaacaagucgc ..................... ..................... Crystal Structure of the Homo sapiens Mitochondrial Ribosomal Decoding Site (Br-derivative); A site of human mitochondrial ribosome 3bno B 21 2.35 URS000080DD7E_32630 18346970 32630 gcgucaccncgaacaagucgc ..................... ..................... Crystal Structure of the Homo sapiens Mitochondrial Ribosomal Decoding Site (Br-derivative); A site of human mitochondrial ribosome 3bno C 21 2.35 URS000080DD7E_32630 18346970 32630 gcgucaccncgaacaagucgc ..................... ..................... Crystal Structure of the Homo sapiens Mitochondrial Ribosomal Decoding Site (Br-derivative); A site of human mitochondrial ribosome 3bno D 21 2.35 URS000080DD7E_32630 18346970 32630 gcgucaccncgaacaagucgc ..................... ..................... Crystal Structure of the Homo sapiens Mitochondrial Ribosomal Decoding Site (Br-derivative); A site of human mitochondrial ribosome 3bnp A 22 2.7 URS000080DE39_32630 18346970 32630 cgcgucaccccgggcaagucgc ...................... ...................... Crystal Structure of the Homo sapiens Mitochondrial Ribosomal Decoding Site (A1555G Mutant); A site of human mitochondrial ribosome, A chain 3bnp B 21 2.7 URS000080DD5F_32630 18346970 32630 gcgucaccccgggcaagucgc ..................... ..................... Crystal Structure of the Homo sapiens Mitochondrial Ribosomal Decoding Site (A1555G Mutant); A site of human mitochondrial ribosome, B chain 3bnq A 23 2.0 URS000080DE36_32630 18346970 32630 uugcgucaccncgagcaagucgc ....................... ....................... Crystal Structure of the Homo sapiens Mitochondrial Ribosomal Decoding Site in the Presence of SrCl2 (A1555G mutant, Br-derivative); A site of human mitochondrial ribosome, A chain 3bnq B 23 2.0 URS000080DE36_32630 18346970 32630 uugcgucaccncgagcaagucgc ....................... ....................... Crystal Structure of the Homo sapiens Mitochondrial Ribosomal Decoding Site in the Presence of SrCl2 (A1555G mutant, Br-derivative); A site of human mitochondrial ribosome, A chain 3bnq C 23 2.0 URS000080DE36_32630 18346970 32630 uugcgucaccncgagcaagucgc ....................... ....................... Crystal Structure of the Homo sapiens Mitochondrial Ribosomal Decoding Site in the Presence of SrCl2 (A1555G mutant, Br-derivative); A site of human mitochondrial ribosome, A chain 3bnq D 21 2.0 URS000080E215_32630 18346970 32630 gcgucaccncgagcaagucgc ..................... ..................... Crystal Structure of the Homo sapiens Mitochondrial Ribosomal Decoding Site in the Presence of SrCl2 (A1555G mutant, Br-derivative); A site of human mitochondrial ribosome, B chain 3bnr A 23 2.1 URS000080DE36_32630 18346970 32630 uugcgucaccncgagcaagucgc ....................... ....................... Crystal Structure of the Homo sapiens Mitochondrial Ribosomal Decoding Site in the presence of nonspecifically bound paromomycin (A1555G mutant, Br-derivative); A site of human mitochondrial ribosome, chain one 3bnr B 22 2.1 URS000080DE38_32630 18346970 32630 ugcgucaccncgagcaagucgc ...................... ...................... Crystal Structure of the Homo sapiens Mitochondrial Ribosomal Decoding Site in the presence of nonspecifically bound paromomycin (A1555G mutant, Br-derivative); A site of human mitochondrial ribosome, chain two 3bnr C 23 2.1 URS000080DE36_32630 18346970 32630 uugcgucaccncgagcaagucgc ....................... ....................... Crystal Structure of the Homo sapiens Mitochondrial Ribosomal Decoding Site in the presence of nonspecifically bound paromomycin (A1555G mutant, Br-derivative); A site of human mitochondrial ribosome, chain one 3bnr D 21 2.1 URS000080E215_32630 18346970 32630 gcgucaccncgagcaagucgc ..................... ..................... Crystal Structure of the Homo sapiens Mitochondrial Ribosomal Decoding Site in the presence of nonspecifically bound paromomycin (A1555G mutant, Br-derivative); A site of human mitochondrial ribosome, chain three 3bns A 23 1.9 URS000080DE36_32630 18346970 32630 uugcgucaccncgagcaagucgc ....................... ....................... Crystal Structure of the Homo sapiens Mitochondrial Ribosomal Decoding Site (A1555G mutant, Br-derivative); A site of human mitochondrial ribosome, chain three 3bns B 22 1.9 URS000080DE38_32630 18346970 32630 ugcgucaccncgagcaagucgc ...................... ...................... Crystal Structure of the Homo sapiens Mitochondrial Ribosomal Decoding Site (A1555G mutant, Br-derivative); A site of human mitochondrial ribosome, chain two 3bns C 23 1.9 URS000080DE36_32630 18346970 32630 uugcgucaccncgagcaagucgc ....................... ....................... Crystal Structure of the Homo sapiens Mitochondrial Ribosomal Decoding Site (A1555G mutant, Br-derivative); A site of human mitochondrial ribosome, chain three 3bns D 21 1.9 URS000080E215_32630 18346970 32630 gcgucaccncgagcaagucgc ..................... ..................... Crystal Structure of the Homo sapiens Mitochondrial Ribosomal Decoding Site (A1555G mutant, Br-derivative); A site of human mitochondrial ribosome, chain three 3bnt A 22 2.3 URS000080DEF9_32630 18346970 32630 cgcgucaccncgagcaagucgc ...................... ...................... Crystal Structure of the Homo sapiens Mitochondrial Ribosomal Decoding Site in the Presence of [Co(NH3)6]Cl3 (A1555G mutant, Br-derivative); A site of human mitochondrial ribosome 3bo0 F 19 9.6 URS000080DDCE_562 18158904 562 acagguuaauauuccugua <<<<<........>>>>>. (((((........))))). Ribosome-SecY complex; 23S RIBOSOMAL RNA 3bo1 F 19 9.6 URS000080DDCE_562 18158904 562 acagguuaauauuccugua <<<<<........>>>>>. (((((........))))). Ribosome-SecY complex; 23S RIBOSOMAL RNA 3bo2 B 197 3.31 RF00028 URS000080E37C_32630 18408159 0000372 32630 ngccgugugccuugcgccgggaaaccacgcaagggauggugucaaauucggcgaaaccuaagcgcccgcccgggcguauggcaacgccgagccaagcuucgcagccauugcacuccggcugcgaugaagguguagagacuagacggcacccaccuaaggcaaacgcuauggugaaggcauaguccagggaguggcgn .........<<<<<<<..<<....>>.>>>>>>>...<<<<<<....<<<<<<...<<...<<<<<......>>>>>..>>...>>>>>><<<.....<<<<<<<<..........>>>>>>>>....>>>.....(((((...>>>>>><<<<...<<<....>>>..>>>>......)))))............. .........(((((((..((....)).)))))))...((((((....((((((...((...((((((....))))))..))...))))))(((...(.((((.(((..........))).)))).)..)))...[.[[[[[...))))))((((...(((....)))..))))......]]]]]]............ A relaxed active site following exon ligation by a group I intron; Group I intron P9 3bo2 C 16 3.31 URS000080E169_32630 18408159 32630 aagccacacaaaccag ................ ................ A relaxed active site following exon ligation by a group I intron; RNA (5'-R(*AP*AP*GP*CP*CP*AP*CP*AP*CP*AP*AP*AP*CP*CP*AP*G)-3') 3bo3 B 197 3.4 RF00028 URS000080E37C_32630 18408159 0000372 32630 ngccgugugccuugcgccgggaaaccacgcaagggauggugucaaauucggcgaaaccuaagcgcccgcccgggcguauggcaacgccgagccaagcuucgcagccauugcacuccggcugcgaugaagguguagagacuagacggcacccaccuaaggcaaacgcuauggugaaggcauaguccagggaguggcgn .........<<<<<<<..<<....>>.>>>>>>>...<<<<<<....<<<<<<...<<...<<<<<<....>>>>>>..>>...>>>>>><<<...<.<<<<<<<<..........>>>>>>>>.>..>>>.....(((((...>>>>>><<<<...<<<....>>>..>>>>......)))))............. .........(((((((..((....)).)))))))...((((((....((.(((...((...((((((....))))))..))...))).))(((...(.((((((((..........)))))))).)..)))...[.[[[[[...))))))((((...(((....)))..))))......]]]]]]............ A relaxed active site following exon ligation by a group I intron; Group I intron P9 3bo3 C 16 3.4 URS000080E169_32630 18408159 32630 aagccacacaaaccag ................ ................ A relaxed active site following exon ligation by a group I intron; RNA (5'-R(*AP*AP*GP*CP*CP*AP*CP*AP*CP*AP*AP*AP*CP*CP*AP*G)-3') 3bo4 B 197 3.33 RF00028 URS000080E37C_32630 18408159 0000372 32630 ngccgugugccuugcgccgggaaaccacgcaagggauggugucaaauucggcgaaaccuaagcgcccgcccgggcguauggcaacgccgagccaagcuucgcagccauugcacuccggcugcgaugaagguguagagacuagacggcacccaccuaaggcaaacgcuauggugaaggcauaguccagggaguggcgn .........<<<<<<<..<<....>>.>>>>>>>...<<<<<<....<<<<<<...<<...<<<<<<....>>>>>>..>>...>>>>>><<<...<.<<<<<<<<..........>>>>>>>>.>..>>>.....(((((...>>>>>><<<<...<<<....>>>..>>>>......)))))............. .........(((((((..((....)).)))))))...((((((....((((((...((...((((((....))))))..))...))))))(((...(.((((((((..........)))))))).)..)))...[.[[[[[...))))))((((...(((....)))..))))......]]]]]]............ A relaxed active site following exon ligation by a group I intron; Group I intron P9 3bo4 C 16 3.33 URS000080E169_32630 18408159 32630 aagccacacaaaccag ................ ................ A relaxed active site following exon ligation by a group I intron; DNA/RNA (5'-R(*AP*AP*GP*CP*CP*AP*CP*AP*CP*AP*AP*AP*CP*CP*A)-D(P*DG)-3') 3c3z A 23 1.5 URS000080E167_32630 18435520 32630 cungcugaagugcacacagcaag ....................... ...................... Crystal structure of HIV-1 subtype F DIS extended duplex RNA bound to ribostamycin; HIV-1 subtype F genomic RNA 3c3z B 23 1.5 URS000080E167_32630 18435520 32630 cungcugaagugcacacagcaag ....................... ...................... Crystal structure of HIV-1 subtype F DIS extended duplex RNA bound to ribostamycin; HIV-1 subtype F genomic RNA 3c44 A 23 2.0 URS000080E167_32630 18435520 32630 cuugcugaagugcacacagcaag ....................... ....................... Crystal structure of HIV-1 subtype F DIS extended duplex RNA bound to paromomycin; HIV-1 subtype F genomic RNA 3c44 B 23 2.0 URS000080E167_32630 18435520 32630 cuugcugaagugcacacagcaag ....................... ....................... Crystal structure of HIV-1 subtype F DIS extended duplex RNA bound to paromomycin; HIV-1 subtype F genomic RNA 3c5d A 23 1.8 URS000080E167_32630 18435520 32630 cungcugaagugcacacagcaag ....................... ...................... Crystal structure of HIV-1 subtype F DIS extended duplex RNA bound to lividomycin; 'HIV-1 subtype F genomic RNA 3c5d B 23 1.8 URS000080E167_32630 18435520 32630 cungcugaagugcacacagcaag ....................... ...................... Crystal structure of HIV-1 subtype F DIS extended duplex RNA bound to lividomycin; 'HIV-1 subtype F genomic RNA 3c7r A 23 1.7 URS000080E167_32630 18435520 32630 cungcugaagugcacacagcaag ....................... ...................... Crystal Structure of HIV-1 subtype F DIS extended duplex RNA bound to neomycin; HIV-1 subtype F genomic RNA 3c7r B 23 1.7 URS000080E167_32630 18435520 32630 cungcugaagugcacacagcaag ....................... ...................... Crystal Structure of HIV-1 subtype F DIS extended duplex RNA bound to neomycin; HIV-1 subtype F genomic RNA 3cc2 0 2754 2.4 RF02540,RF00002 URS000080E102_2238 18455733,15184028,15520287 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagcuguggggagccgcacggaggcgaagaaccacagauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaacgugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucuucacgaagucucuuggaauagagcgugauacagggugacaaccccguacugaagaccaguacgcugugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccuugacgaaugaccgagacgcgagucuccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucuguauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgcuguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaagcaggggcgagagcuccuguggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucucaccgcaacucgacugagacgaaaugggaaacagguuaauauuccugugccaucaugcagugaaaguugacgcccuggggucgaucacgccgggcaucgcccggucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcaugauguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcgaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggucaucucagccggggacccggcgaagagugcaagagcaaaagaugacuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcugggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa 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...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......((((.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......))))...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((.(((....(....(((((....))))).....)...))).))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. The Refined Crystal Structure of the Haloarcula Marismortui Large Ribosomal Subunit at 2.4 Angstrom Resolution with rrnA Sequence for the 23S rRNA and Genome-derived Sequences for r-Proteins; 23S RIBOSOMAL RNA 3cc2 9 122 2.4 RF00001 URS00000A7E81_2238 18455733,15184028,15520287 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccagggaguacuggagugcgcgagccucugggaaauccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<.<<.....<<<<<<.<<....>>>>>>>>....>>.>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...((.((.....((((((.((....))))))))....)).))...))))))... The Refined Crystal Structure of the Haloarcula Marismortui Large Ribosomal Subunit at 2.4 Angstrom Resolution with rrnA Sequence for the 23S rRNA and Genome-derived Sequences for r-Proteins; 5S RIBOSOMAL RNA 3cc4 0 2754 2.7 RF02540,RF00002 URS000080E102_2238 18455733,12860128 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagcuguggggagccgcacggaggcgaagaaccacagauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaacgugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucuucacgaagucucuuggaauagagcgugauacagggugacaaccccguacugaagaccaguacgcugugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccuugacgaaugaccgagacgcgagucuccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucuguauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgcuguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaagcaggggcgagagcuccuguggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucucaccgcaacucgacugagacgaaaugggaaacagguuaauauuccugugccaucaugcagugaaaguugacgcccuggggucgaucacgccgggcaucgcccggucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcaugauguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcgaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggucaucucagccggggacccggcgaagagugcaagagcaaaagaugacuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcugggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>...<<<<<.....<<.....>>....>>>>>...<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<<<<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>>>>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<.<<<.........<<<<<....>>>>>.........>>>.>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<<<<<.....>>>>>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<....<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>..>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......((((.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......))))...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((.(((....(....(((((....))))).....)...))).))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Co-crystal Structure of Anisomycin Bound to the 50S Ribosomal Subunit; 23S ribosomal RNA 3cc4 9 122 2.7 RF00001 URS00000A7E81_2238 18455733,12860128 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccagggaguacuggagugcgcgagccucugggaaauccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<.<<.....<<<<<<.<<....>>>>>>>>....>>.>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...((.((.....((((((.((....))))))))....)).))...))))))... Co-crystal Structure of Anisomycin Bound to the 50S Ribosomal Subunit; 5S ribosomal RNA 3cc7 0 2754 2.7 RF02540,RF00002 URS000080E214_2238 18455733 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagcuguggggagccgcacggaggcgaagaaccacagauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaacgugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucuucacgaagucucuuggaauagagcgugauacagggugacaaccccguacugaagaccaguacgcugugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccuugacgaaugaccgagacgcgagucuccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucuguauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgcuguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaagcaggggcgagagcuccuguggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucucaccgcaacucgacugagacgaaaugggaaacagguuaauauuccugugccaucaugcagugaaaguugacgcccuggggucgaucacgccgggcaucgcccggucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcaugauguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcaaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggucaucucagccggggacccggcgaagagugcaagagcaaaagaugacuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaauagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcugggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>..<<<<<<.....<<.....>>....>>>>>>..<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<<<<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>>>>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<.<<<.........<<<<<....>>>>>.........>>>.>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<<<<<.....>>>>>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<<...<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>.>>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......((((.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......))))...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......(...(((.....))).............)).....)))))))))......(.((((((((((....((((((.(((....(....(((((....))))).....)...))).))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Structure of Anisomycin resistant 50S Ribosomal Subunit: 23S rRNA mutation C2487U; 23S ribosomal RNA 3cc7 9 122 2.7 RF00001 URS00000A7E81_2238 18455733 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccagggaguacuggagugcgcgagccucugggaaauccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<.<<.....<<<<<<.<<....>>>>>>>>....>>.>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...((.((.....((((((.((....))))))))....)).))...))))))... Structure of Anisomycin resistant 50S Ribosomal Subunit: 23S rRNA mutation C2487U; 5S ribosomal RNA 3cce 0 2754 2.75 RF02540,RF00002 URS000080DEE9_2238 18455733 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagcuguggggagccgcacggaggcgaagaaccacagauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaacgugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucuucacgaagucucuuggaauagagcgugauacagggugacaaccccguacugaagaccaguacgcugugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccuugacgaaugaccgagacgcgagucuccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucuguauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgcuguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaagcaggggcgagagcuccuguggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucucaccgcaacucgacugagacgaaaugggaaacagguuaauauuccugugccaucaugcagugaaaguugacgcccuggggucgaucacgccgggcaucgcccggucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcaugauguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcaaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggucaucucagccggggacccggcgaagagugcaagagcaaaagaugacuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccacgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcugggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>...<<<<<.....<<.....>>....>>>>>...<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<<<<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>>>>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<.<<<.........<<<<<....>>>>>.........>>>.>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<.<<<.....>>>.>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<....<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>..>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......((((.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......))))...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((.(((....(....(((((....))))).....)...))).))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.(((....(((((((....)))))))....[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))(.....)........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Structure of Anisomycin resistant 50S Ribosomal Subunit: 23S rRNA mutation U2535A; 23S RIBOSOMAL RNA 3cce 9 122 2.75 RF00001 URS00000A7E81_2238 18455733 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccagggaguacuggagugcgcgagccucugggaaauccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<.<<.....<<<<<<.<<....>>>>>>>>....>>.>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...((.(......((((((.((....)))))))).....).))...))))))... Structure of Anisomycin resistant 50S Ribosomal Subunit: 23S rRNA mutation U2535A; 5S RIBOSOMAL RNA 3ccj 0 2754 3.3 RF02540,RF00002 URS000080E310_2238 18455733 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagcuguggggagccgcacggaggcgaagaaccacagauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaacgugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucuucacgaagucucuuggaauagagcgugauacagggugacaaccccguacugaagaccaguacgcugugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccuugacgaaugaccgagacgcgagucuccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucuguauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgcuguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaagcaggggcgagagcuccuguggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucucaccgcaacucgacugagacgaaaugggaaacagguuaauauuccugugccaucaugcagugaaaguugacgcccuggggucgaucacgccgggcaucgcccggucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcaugauguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcaaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggucaucucagccggggacccggcgaagagugcaagagcaaaagaugacuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuacuucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcugggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>..<<<<<<.....<<.....>>....>>>>>>..<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<<<<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>>>>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<.<<<....<....<<<<<....>>>>>.....>...>>>.>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<<<<<.....>>>>>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<....<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<..[[.>>>>>>....<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>...........>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>..>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>......<<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>>......<.<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>..>...>>>..>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((.(....).))....))).....((((((((......((((.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......))))...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((.(((....(....(((((....))))).....)...))).))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.((...(((.........)))...))........(..........)..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)......))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))(.....)........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..((....))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..))))))......(((((.(.((((((...((.......))...))))))...)))).))......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((....(((...((((((((((}}..)))))...))))).[.)))..)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Structure of Anisomycin resistant 50S Ribosomal Subunit: 23S rRNA mutation C2534U; 23S RIBOSOMAL RNA 3ccj 9 122 3.3 RF00001 URS00000A7E81_2238 18455733 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccagggaguacuggagugcgcgagccucugggaaauccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<.<<.....<<<<<<.<<....>>>>>>>>....>>.>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...((.((.....((((((.((....))))))))....)).))...))))))... Structure of Anisomycin resistant 50S Ribosomal Subunit: 23S rRNA mutation C2534U; 5S RIBOSOMAL RNA 3ccl 0 2754 2.9 RF02540,RF00002 URS000080DD39_2238 18455733 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagcuguggggagccgcacggaggcgaagaaccacagauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaacgugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucuucacgaagucucuuggaauagagcgugauacagggugacaaccccguacugaagaccaguacgcugugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccuugacgaaugaccgagacgcgagucuccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucuguauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgcuguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaagcaggggcgagagcuccuguggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucucaccgcaacucgacugagacgaaaugggaaacagguuaauauuccugugccaucaugcagugaaaguugacgcccuggggucgaucacgccgggcaucgcccggucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcaugauguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcaaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggucaucucagccggggacccggcgaagagugcaagagcaaaagaugacuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccccgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcugggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>..<<<<<<.....<<.....>>....>>>>>>..<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<<<<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>>>>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<.<<<.........<<<<<....>>>>>.........>>>.>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<<<<<.....>>>>>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<<...<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>.>>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......((((.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......))))...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((.(((....(....(((((....))))).....)...))).))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Structure of Anisomycin resistant 50S Ribosomal Subunit: 23S rRNA mutation U2535C. Density for Anisomycin is visible but not included in model.; 23S RIBOSOMAL RNA 3ccl 9 122 2.9 RF00001 URS00000A7E81_2238 18455733 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccagggaguacuggagugcgcgagccucugggaaauccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<.<<.....<<<<<<.<<....>>>>>>>>....>>.>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...((.((.....((((((.((....))))))))....)).))...))))))... Structure of Anisomycin resistant 50S Ribosomal Subunit: 23S rRNA mutation U2535C. Density for Anisomycin is visible but not included in model.; 5S RIBOSOMAL RNA 3ccm 0 2754 2.55 RF02540,RF00002 URS000080E039_2238 18455733 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagcuguggggagccgcacggaggcgaagaaccacagauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaacgugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucuucacgaagucucuuggaauagagcgugauacagggugacaaccccguacugaagaccaguacgcugugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccuugacgaaugaccgagacgcgagucuccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucuguauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgcuguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaagcaggggcgagagcuccuguggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucucaccgcaacucgacugagacgaaaugggaaacagguuaauauuccugugccaucaugcagugaaaguugacgcccuggggucgaucacgccgggcaucgcccggucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcaugauguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcaaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggucaucucagccggggacccggcgaagagugcaagagcaaaagaugacuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucguuagcugggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>...<<<<<.....<<.....>>....>>>>>...<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<<<<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>>>>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<.<<<.........<<<<<....>>>>>.........>>>.>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<.<<<.....>>>.>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<<..<<<<.......>>>>..>>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<<...<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>.>>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......((((.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......))))...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......(...(((.....))).............)).....)))))))))......(.((((((((((....((((((.(((....(....(((((....))))).....)...))).))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..(...)..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Structure of Anisomycin resistant 50S Ribosomal Subunit: 23S rRNA mutation G2611U; 23S RIBOSOMAL RNA 3ccm 9 122 2.55 RF00001 URS00000A7E81_2238 18455733 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccagggaguacuggagugcgcgagccucugggaaauccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<<.............>>>>..>>....>>>>>>.>><..<<.<<.....<<<<<<.<<....>>>>>>>>....>>.>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...((.((.....((((((.((....))))))))....)).))...))))))... Structure of Anisomycin resistant 50S Ribosomal Subunit: 23S rRNA mutation G2611U; 5S RIBOSOMAL RNA 3ccq 0 2754 2.9 RF02540,RF00002 URS000080E20E_2238 18455733 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagcuguggggagccgcacggaggcgaagaaccacagauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaacgugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucuucacgaagucucuuggaauagagcgugauacagggugacaaccccguacugaagaccaguacgcugugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccuugacgaaugaccgagacgcgagucuccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucuguauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgcuguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaagcaggggcgagagcuccuguggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucucaccgcaacucgacugagacgaaaugggaaacagguuaauauuccugugccaucaugcagugaaaguugacgcccuggggucgaucacgccgggcaucgcccggucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcaugauguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcaaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggucaucucagccggggacccggcgaagagugcaagagcaaaagaugacuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacugagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcugggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>...<<<<<.....<<.....>>....>>>>>...<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<<<<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>>>>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<.<<<.........<<<<<....>>>>>.........>>>.>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<...<<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>>.<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<<<<<.....>>>>>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<<..<<<<.......>>>>..>>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<....<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>..>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......((((.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......))))...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((.(((....(....(((((....))))).....)...))).))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.(((....(((((((....)))))))....[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))(.....)........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Structure of Anisomycin resistant 50S Ribosomal Subunit: 23S rRNA mutation A2488U; 23S RIBOSOMAL RNA 3ccq 9 122 2.9 RF00001 URS00000A7E81_2238 18455733 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccagggaguacuggagugcgcgagccucugggaaauccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<.<<.....<<<<<<.<<....>>>>>>>>....>>.>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...((.((.....((((((.((....))))))))....)).))...))))))... Structure of Anisomycin resistant 50S Ribosomal Subunit: 23S rRNA mutation A2488U; 5S RIBOSOMAL RNA 3ccr 0 2754 3.0 RF02540,RF00002 URS000080E07E_2238 18455733 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagcuguggggagccgcacggaggcgaagaaccacagauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaacgugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucuucacgaagucucuuggaauagagcgugauacagggugacaaccccguacugaagaccaguacgcugugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccuugacgaaugaccgagacgcgagucuccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucuguauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgcuguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaagcaggggcgagagcuccuguggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucucaccgcaacucgacugagacgaaaugggaaacagguuaauauuccugugccaucaugcagugaaaguugacgcccuggggucgaucacgccgggcaucgcccggucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcaugauguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcaaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggucaucucagccggggacccggcgaagagugcaagagcaaaagaugacuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaaccgagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcugggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<.....>>...<<<<<.....<<.....>>....>>>>>...<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<<<<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>>>>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<.<<<.........<<<<<....>>>>>.........>>>.>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<...<<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>>.<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<<<<<.....>>>>>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<<..<<<<.......>>>>..>>>........<<<......>>>..>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<<...<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>.>>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......((((.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......))))...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......(...(((.....))).............)).....)))))))))......(.((((((((((....((((((.(((....(....(((((....))))).....)...))).))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....((..(((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..))).....)).. Structure of Anisomycin resistant 50S Ribosomal Subunit: 23S rRNA mutation A2488C. Density for anisomycin is visible but not included in the model.; 23S RIBOSOMAL RNA 3ccr 9 122 3.0 RF00001 URS00000A7E81_2238 18455733 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccagggaguacuggagugcgcgagccucugggaaauccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<.<<.....<<<<<<.<<....>>>>>>>>....>>.>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...((.(......((((((.((....)))))))).....).))...))))))... Structure of Anisomycin resistant 50S Ribosomal Subunit: 23S rRNA mutation A2488C. Density for anisomycin is visible but not included in the model.; 5S RIBOSOMAL RNA 3ccs 0 2754 2.95 RF02540,RF00002 URS000080E271_2238 18455733 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagcuguggggagccgcacggaggcgaagaaccacagauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaacgugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucuucacgaagucucuuggaauagagcgugauacagggugacaaccccguacugaagaccaguacgcugugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccuugacgaaugaccgagacgcgagucuccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucuguauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgcuguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaagcaggggcgagagcuccuguggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucucaccgcaacucgacugagacgaaaugggaaacagguuaauauuccugugccaucaugcagugaaaguugacgcccuggggucgaucacgccgggcaucgcccggucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcaugauguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcaaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggucaucucagccggggacccggcgaagagugcaagagcaaaagaugacuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuaggaauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcugggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<.....>>...<<<<<.....<<.....>>....>>>>>...<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<<<<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>>>>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<.<<<....<....<<<<<....>>>>>.....>...>>>.>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<<<<<.....>>>>>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<<...<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>.>>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......((((.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......))))...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((.(((....(....(((((....))))).....)...))).))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Structure of Anisomycin resistant 50S Ribosomal Subunit: 23S rRNA mutation G2482A; 23S RIBOSOMAL RNA 3ccs 9 122 2.95 RF00001 URS00000A7E81_2238 18455733 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccagggaguacuggagugcgcgagccucugggaaauccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<.<<.....<<<<<<.<<....>>>>>>>>....>>.>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...((.(......((((((.((....)))))))).....).))...))))))... Structure of Anisomycin resistant 50S Ribosomal Subunit: 23S rRNA mutation G2482A; 5S RIBOSOMAL RNA 3ccu 0 2754 2.8 RF02540,RF00002 URS000080E353_2238 18455733 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagcuguggggagccgcacggaggcgaagaaccacagauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaacgugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucuucacgaagucucuuggaauagagcgugauacagggugacaaccccguacugaagaccaguacgcugugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccuugacgaaugaccgagacgcgagucuccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucuguauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgcuguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaagcaggggcgagagcuccuguggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucucaccgcaacucgacugagacgaaaugggaaacagguuaauauuccugugccaucaugcagugaaaguugacgcccuggggucgaucacgccgggcaucgcccggucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcaugauguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcaaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggucaucucagccggggacccggcgaagagugcaagagcaaaagaugacuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuaggcauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcugggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>..<<<<<<.....<<.....>>....>>>>>>..<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<<<<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>>>>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<.<<<.........<<<<<....>>>>>.........>>>.>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<<<<<.....>>>>>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<<..<<<<.......>>>>..>>>........<<<......>>>..>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<<...<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>.>>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......((((.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......))))...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((.(((....(....(((((....))))).....)...))).))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Structure of Anisomycin resistant 50S Ribosomal Subunit: 23S rRNA mutation G2482C; 23S RIBOSOMAL RNA 3ccu 9 122 2.8 RF00001 URS00000A7E81_2238 18455733 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccagggaguacuggagugcgcgagccucugggaaauccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<.<<.....<<<<<<.<<....>>>>>>>>....>>.>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...((.((.....((((((.((....))))))))....)).))...))))))... Structure of Anisomycin resistant 50S Ribosomal Subunit: 23S rRNA mutation G2482C; 5S RIBOSOMAL RNA 3ccv 0 2754 2.9 RF02540,RF00002 URS000080DE11_2238 18455733 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagcuguggggagccgcacggaggcgaagaaccacagauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaacgugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucuucacgaagucucuuggaauagagcgugauacagggugacaaccccguacugaagaccaguacgcugugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccuugacgaaugaccgagacgcgagucuccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucuguauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgcuguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaagcaggggcgagagcuccuguggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucucaccgcaacucgacugagacgaaaugggaaacagguuaauauuccugugccaucaugcagugaaaguugacgcccuggggucgaucacgccgggcaucgcccggucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcaugauguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcaaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggucaucucagccggggacccggcgaagagugcaagagcaaaagaugacuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcuaggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>...<<<<<.....<<.....>>....>>>>>...<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<<<<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>>>>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<.<<<.........<<<<<....>>>>>.........>>>.>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<<<<<.....>>>>>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<<...<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>.>>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......((((.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......))))...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((.(((....(....(((((....))))).....)...))).))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Structure of Anisomycin resistant 50S Ribosomal Subunit: 23S rRNA mutation G2616A; 23S RIBOSOMAL RNA 3ccv 9 122 2.9 RF00001 URS00000A7E81_2238 18455733 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccagggaguacuggagugcgcgagccucugggaaauccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<.<<.....<<<<<<.<<....>>>>>>>>....>>.>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...((.(......((((((.((....)))))))).....).))...))))))... Structure of Anisomycin resistant 50S Ribosomal Subunit: 23S rRNA mutation G2616A; 5S RIBOSOMAL RNA 3cd6 0 2754 2.75 RF02540,RF00002 URS000080DE11_2238 18455733 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagcuguggggagccgcacggaggcgaagaaccacagauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaacgugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucuucacgaagucucuuggaauagagcgugauacagggugacaaccccguacugaagaccaguacgcugugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccuugacgaaugaccgagacgcgagucuccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucuguauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgcuguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaagcaggggcgagagcuccuguggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucucaccgcaacucgacugagacgaaaugggaaacagguuaauauuccugugccaucaugcagugaaaguugacgcccuggggucgaucacgccgggcaucgcccggucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcaugauguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcaaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggucaucucagccggggacccggcgaagagugcaagagcaaaagaugacuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcuaggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>...<<<<<.....<<.....>>....>>>>>...<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<<<<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>>>>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<.<<<.........<<<<<....>>>>>.........>>>.>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<<<<<.....>>>>>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<<...<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>.>>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......((((.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......))))...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......(...(((.....))).............)).....)))))))))......(.((((((((((....((((((.(((....(....(((((....))))).....)...))).))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).).....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Co-cystal of large Ribosomal Subunit mutant G2616A with CC-Puromycin; 23S RIBOSOMAL RNA 3cd6 9 122 2.75 RF00001 URS00000A7E81_2238 18455733 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccagggaguacuggagugcgcgagccucugggaaauccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<.<<.....<<<<<<.<<....>>>>>>>>....>>.>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...((.(......((((((.((....)))))))).....).))...))))))... Co-cystal of large Ribosomal Subunit mutant G2616A with CC-Puromycin; 5S RIBOSOMAL RNA 3cf5 X 2686 3.3 RF02540,RF02541 URS000080DEF1_1299 18406324 0003735 0005840 1299 ggucaagauaguaaggguccacgguggaugcccuggcgcuggagccgaugaaggacgcgauuaccugcgaaaagccccgacgagcuggagauacgcuuugacucggggauguccgaauggggaaacccaccucguaagagguauccgcaaggaugggaacucagggaacugaaacaucucaguaccugaaggagaagaaagagaauucgauuccguuaguagcggcgagcgaacccggaucagcccaaucaagccgaaguggcuggaaagcuacaccucagaaggugagaguccuguaggcgaacgagaggucguuguucgugaaacgaugacugaauccgcgcggaccaccgcgcaaggcuaaauacucccagugaccgauagcgcauaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaagagaaccugaaaccguggacuuacaagcagucauggcaccuuaugcguguuauggcgugccuauugaagcaugagccggcgacuuagaccugacgugcgagcuuaaguugaaaaacggaggcggagcgaaagcgaguccgaauagggcggcauuaguacgucgggcuagacucgaaaccaggugagcuaagcaugaccagguugaaacccccgugacagggggcggaggaccgaaccggugccugcugaaacagucucggaugaguuguguuuaggagugaaaagcuaaccgaaccuggagauagcuaguucuccccgaaauguauugagguacagccucggauguugaccauguccuguagagcacucacaaggcuaaaaccuuaugaaacuccgaaggggcacgcguuuaguccgggagugaggcugcgagagcuaacuuccguagccgagagggaaacaacccagaccaucagcuaaggucccuaaaugaucgcucagugguuaaggaugugucgucgcauagacagccaggagguuggcuuagaagcagccacccuucaaagagugcguaauagcucacuggucgagugacgaugcgccgaaaaugaucggggcucaagugaucuaccgaagcuauggauucaacucgcgaagcgaguugucugguaggggagcguucaguccgcggagaagccauaccggaaggagugguggagccgacugaagugcggaugccggcaugaguaacgauaaaagaagugagaaucuucuucgccguaaggacaaggguuccuggggaagggucguccgcccagggaaagucgggaccuaaggugaggccgaacggcgcagccgauggacagcaggucaagauuccugcaccgaucauguggagugauggagggacgcauuacgcuauccaaugccaagcuauggcuaugcugguugguacgcucaagggcgaucgggucagaaaaucuaccggucacaugccucagacguaucgggagcuuccucggaagcgaaguuggaaacgcgacggugccaagaaaagcuucuaaacguugaaacaugauugcccguaccgcaaaccgacacagguguccgagugucaaugcacuaaggcgcgcgagagaacccucguuaaggaacuuugcaaucucaccccguaacuucggaagaagggguccccacgcuucgcguggggcgcagugaauaggcccaggcgacuguuuaccaaaaucacagcacucugccaacacgaacaguggacguauagggugugacgccugcccggugccggaaggucaaguggagcggugcaagcugcgaaaugaagccccggugaacggcuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaggcguaacgaucugggcgcugucucaacgagggacucggugaaauugaauuggcuguaaagaugcggccuacccguagcaggacgaaaagaccccguggagcuuuacuauagucuggcauugggauucggguuucuagaaacuuggauuucuaaccugaaaaaucacuuucggggaccgugcuuggcggguaguuugacuggggcggucgccucccaaaauguaacggaggcgcccaaaggucaccucaagacgguuggaaaucgucuguagagcgcaaagguagaagguggcuugacugcgagacugacacgucgagcagggaggaaacucgggcuuagugaaccggugguaccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagaguccauaucggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgcuacgggcgcaggagaauugaggggaguugcuccuaguacgagaggaccggagugaacggaccgcuggucucccugcugucguaccaacggcacaugcaggguagcuauguccggaacggauaaccgcugaaagcaucuaagcgggaagccagccccaagaugaguucucccacuguuuaucagguaagacucccggaagaccaccggguuaagaggccaggcgugcacgcauagcaauguguucagcggacuggugcucaucagucgaggucuugacca <<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<<((..((>>>>.....<<<<<<...<<.))..))..>>......>>>>>>...>>>....<<<....>>><<<<<....>>>>><<<<....>>>>>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<......<<.....>>.....>>>>...<<<...<<..<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>....>>..<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>..............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<.......>>>>>>>>>>...<............>.<<<<<<....<<<.<<<<<<<<<<..<<<...<<<....>>>...>>>...<<....>>...<<......>>.........>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<.....<<<<<......>>>>>......>>>...<<<<.<.<<........>>.>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<...<<<<.<<<<<<...<<<...<<<.<<<<......>>>>.>>>..>>.>...>>>>>>.>.>>>..>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<......<.<<<<<.<<<..<<<<.......>>>>..>>>.........<<......>>...>>>>>.>..>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><..<<<<<<<<...>>>>>>>>..>....>>>>>><.<<<<<<<.<<......<<<<<.<<....>>.>>>>>...>>.>>>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<<..>>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<...<<...<<<<....<<<<..<<<..<<<<<.<<<<.<<...[[....>>>>>><<<<<<<.<<..<<<<<<<<<<...<<.....>>.>>>>>>....>>>>..>>>>>>>>>...<<<<<....>>>>>....>>>>>...>>>...>>>>.........>>>>...>>......>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<<<<<<<...>>>>>>>>............<<<<<<<<<..<<...........>>..<<<<<<<.....<<<.....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>>.......<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<>>>>>>>>>>>>>>>...<<<<<<........>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.]].>>>>>>...>>>>>...>>>>.>>>>>....<<....<<<<<...........>>>>>....>>..>>>>.......>>>>>>>..<<.......>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>>>. ((((((((........((((((((.....(((..(((.((((((((......((((((.[[..[[.))).....((((((...((.]]..]]..))......))))))...)))....(((....)))(((((....)))))((((....))))))...((((((.....(......)......))))).).........((....))...((((......((.....)).....))))...(((...((..(((...(((((......)))))[[(...).(((.....]])))...)))....))..(((((((((.[.....)))))))))......(((((].[[[[)))))..)))......)).)))).).))..............((....))....))......(..((((....))))............)).....)))))))).......(.((((((((((..<....)))))))))).[.(.(........).).((((((....(((.((((((((.(..(((...(((....)))...)))...((....))...((......)).........).)))))))))))..((.(...((((((.....((((((((((.((((....(((((......)))))....)[)))...(((..(.((........)).).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((..(((((.((((((...(((...(((.((((......)))).)))..)).)...)))))).).))).)))))))).))..(((((((.((......)).)))))))....(((......)))...((((.(((...((([[[...(.(((((((....(.....((..((((((((.(.....{..((((.(((..(((.........)))..))).....(...((......)).).))))....).)))))))).))..........]]].)..).))))))))))...)))))))(..((((((((...))))))))..)....))))))(.(((((((.((......(((((.((....))>)))))...)).)))))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((((((...((...((((....(((((.(((..(((((.((((.((...{{....))))))(((((((.((..((((((((((...((.....)).))))))....))))..)))))))))...(((((....)))))....)))))...)))..)))))(..).....))))...))......))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(........((((....(.{..).....)))).((((((((...))))))))(...).......(((((((((.].(...........)...(((((((.....(((.....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..))))).......((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((.((((((())))))).)))))))...(((((((......)))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...)..(][.[[[).....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))....((....((((.....}.......))))....))..))))..]....)))))))(.((.......))....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))...))))))))). Thiopeptide antibiotic Thiostrepton bound to the large ribosomal subunit of Deinococcus radiodurans; RRNA-23S RIBOSOMAL RNA 3cf5 Z 122 3.3 RF00001 URS000080E04E_1299 18406324 0003735 0005840 1299 cacccccgugcccauagcacuguggaaccaccccaccccaugccgaacugggucgugaaacacagcagcgccaaugauacucggaccgcagggucccggaaaagucggucagcgcggggguu .<<<<<<<<<<.....<<.<<<<<....<<<<<<<.............>>>>..>>>...>>>>>..>><<<.......<<.<<<<<....>>>>>.>>.......>>>..>>>>>>>>>>. .((((((((((.....((.(((((....(((((((...(.....)...))))..)))...)))))..))(((.......((.(((((....))))).)).......)))..)))))))))). Thiopeptide antibiotic Thiostrepton bound to the large ribosomal subunit of Deinococcus radiodurans; RRNA-5S RIBOSOMAL RNA 3cgp A 12 1.57 URS000080E2E0_32630 18435545 32630 gcgcguaguagc ............ ............ X-ray structure of a pseudouridine-containing yeast spliceosomal U2 snRNA-intron branch site duplex bound to iodide ions; RNA (5'-R(*GP*CP*GP*CP*GP*(PSU)P*AP*GP*UP*AP*GP*C)-3') 3cgp B 13 1.57 URS000080E010_32630 18435545 32630 cgcuacuaacgcg ............. ............. X-ray structure of a pseudouridine-containing yeast spliceosomal U2 snRNA-intron branch site duplex bound to iodide ions; RNA (5'-R(*CP*GP*CP*UP*AP*CP*UP*AP*AP*CP*GP*CP*G)-3') 3cgq A 12 2.55 URS000080E2E0_32630 18435545 32630 gcgcguaguagc ............ ............ X-ray structure of a pseudouridine-containing yeast spliceosomal U2 snRNA-intron branch site duplex; RNA (5'-R(*GP*CP*GP*CP*GP*(PSU)P*AP*GP*UP*AP*GP*C)-3') 3cgq B 13 2.55 URS000080E010_32630 18435545 32630 cgcuacuaacgcg ............. ............. X-ray structure of a pseudouridine-containing yeast spliceosomal U2 snRNA-intron branch site duplex; RNA (5'-R(*CP*GP*CP*UP*AP*CP*UP*AP*AP*CP*GP*CP*G)-3') 3cgr A 12 2.1 URS000080E2E1_32630 18435545 32630 gcgcgguagugc ............ ............ X-ray structure containing the pseudouridylated U2 snRNA and intron branch site consensus sequences; RNA (5'-R(*GP*CP*GP*CP*GP*GP*(PSU)P*AP*GP*UP*GP*C)-3') 3cgr B 13 2.1 URS000080E0C9_32630 18435545 32630 cgcacuaaccgcg ............. ............. X-ray structure containing the pseudouridylated U2 snRNA and intron branch site consensus sequences; RNA (5'-R(*CP*GP*CP*AP*CP*UP*AP*AP*CP*CP*GP*CP*G)-3') 3cgs A 12 1.65 URS000080E2E0_32630 18435545 32630 gcgcguaguagc ............ ............ X-ray structure containing the pseudouridylated U2 snRNA and mammalian intron branch site consensus sequences; RNA (5'-R(*GP*CP*GP*CP*GP*(PSU)P*AP*GP*UP*AP*GP*C)-3') 3cgs B 13 1.65 URS000080E17C_32630 18435545 32630 cgcuacugacgcg ............. ............. X-ray structure containing the pseudouridylated U2 snRNA and mammalian intron branch site consensus sequences; RNA (5'-R(*CP*GP*CP*UP*AP*CP*UP*GP*AP*CP*GP*CP*G)-3') 3ciy C 46 3.41 URS000080DF6F_32630 18420935 32630 auucugcggauuauuuggcaaaggaagcauugacacaugcgccaau .............................................. .............................................. Mouse Toll-like receptor 3 ectodomain complexed with double-stranded RNA; 46-MER 3ciy D 46 3.41 URS000080DD94_32630 18420935 32630 auuggcgcaugugucaaugcuuccuuugccaaauaauccgcagaau .............................................. .............................................. Mouse Toll-like receptor 3 ectodomain complexed with double-stranded RNA; 46-MER 3cjz A 13 1.8 URS000080DDC8_32630 18772248 32630 ggacgnacguccu ............. ............. Effects of N2,N2-dimethylguanosine on RNA structure and stability: crystal structure of an RNA duplex with tandem m22G:A pairs; RNA (5'-R(*GP*GP*AP*CP*GP*(M2G)P*AP*CP*GP*UP*CP*CP*U)-3') 3cjz B 13 1.8 URS000080DDC8_32630 18772248 32630 ggacgnacguccu ............. ............. Effects of N2,N2-dimethylguanosine on RNA structure and stability: crystal structure of an RNA duplex with tandem m22G:A pairs; RNA (5'-R(*GP*GP*AP*CP*GP*(M2G)P*AP*CP*GP*UP*CP*CP*U)-3') 3cma 0 2754 2.8 RF02540,RF00002 URS000080E102_2238 18818369 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagcuguggggagccgcacggaggcgaagaaccacagauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaacgugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucuucacgaagucucuuggaauagagcgugauacagggugacaaccccguacugaagaccaguacgcugugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccuugacgaaugaccgagacgcgagucuccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucuguauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgcuguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaagcaggggcgagagcuccuguggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucucaccgcaacucgacugagacgaaaugggaaacagguuaauauuccugugccaucaugcagugaaaguugacgcccuggggucgaucacgccgggcaucgcccggucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcaugauguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcgaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggucaucucagccggggacccggcgaagagugcaagagcaaaagaugacuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcugggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa 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...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......((((.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......))))...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......(...(((.....))).............)).....)))))))))......(.((((((((((....((((((.(((....(....(((((....))))).....)...))).))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. The structure of CCA and CCA-Phe-Cap-Bio bound to the large ribosomal subunit of Haloarcula marismortui; 23S RIBOSOMAL RNA 3cma 9 122 2.8 RF00001 URS00000A7E81_2238 18818369 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccagggaguacuggagugcgcgagccucugggaaauccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<.<<.....<<<<<<.<<....>>>>>>>>....>>.>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...((.(......((((((.((....)))))))).....).))...))))))... The structure of CCA and CCA-Phe-Cap-Bio bound to the large ribosomal subunit of Haloarcula marismortui; 5S RIBOSOMAL RNA 3cme 0 2754 2.95 RF02540,RF00002 URS000080E102_2238 18818369 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagcuguggggagccgcacggaggcgaagaaccacagauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaacgugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucuucacgaagucucuuggaauagagcgugauacagggugacaaccccguacugaagaccaguacgcugugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccuugacgaaugaccgagacgcgagucuccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucuguauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgcuguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaagcaggggcgagagcuccuguggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucucaccgcaacucgacugagacgaaaugggaaacagguuaauauuccugugccaucaugcagugaaaguugacgcccuggggucgaucacgccgggcaucgcccggucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcaugauguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcgaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggucaucucagccggggacccggcgaagagugcaagagcaaaagaugacuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcugggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa 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...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......((((.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......))))...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((.(((....(....(((((....))))).....)...))).))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...(((((((((((((.{{)))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. The Structure of CA and CCA-PHE-CAP-BIO Bound to the Large Ribosomal Subunit of Haloarcula Marismortui; 50S RIBOSOMAL RNA 3cme 9 122 2.95 RF00001 URS00000A7E81_2238 18818369 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccagggaguacuggagugcgcgagccucugggaaauccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<.<<.....<<<<<<.<<....>>>>>>>>....>>.>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...((.(......((((((.((....)))))))).....).))...))))))... The Structure of CA and CCA-PHE-CAP-BIO Bound to the Large Ribosomal Subunit of Haloarcula Marismortui; 5S RIBOSOMAL RNA 3cpw 0 2754 2.7 RF02540,RF00002 URS000080E267_2238 18494460 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagccauggggagccgcacggaggcgaagaaccauggauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaaugugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucucgacgaagucucuuggaacagagcgugauacagggugacaaccccguacucgagaccaguacgacgugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccccgacgaaugaccgacgcgcgagcguccaguaagacucacgggaagccgauguucugucguacguuuugaaaaacgagccagggagugugucugcauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgccguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaaguaggggugaaaacuccuauggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucauaccgcaacucgacuaugacgaaaugggaaacggguuaauauucccgugccacuaugcagugaaaguugacgcccuggggucgaucacgcugggcaucgcccagucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcauaguguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcaaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggcuaucucagccggggacccggcgaagagugcaagagcaaaagauagcuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugagguuguucgccuauuaaaggaggucgugagcuggguuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa 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...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......(..(.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......)..)...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......(...(((.....))).............)).....)))))))))......(.((((((((((....((((((..((....(....(((((....))))).....)...))..))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. The structure of the antibiotic LINEZOLID bound to the large ribosomal subunit of HALOARCULA MARISMORTUI; 23S RIBOSOMAL RNA 3cpw 9 122 2.7 RF00001 URS00003592C7_2238 18494460 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccggggaguacuggagugcgcgagccucugggaaacccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<<<<.....<<<<<<.<<....>>>>>>>>....>>>>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...(((((.....((((((.((....))))))))....)))))...))))))... The structure of the antibiotic LINEZOLID bound to the large ribosomal subunit of HALOARCULA MARISMORTUI; 5S RIBOSOMAL RNA 3cqs A 13 2.8 URS000080E09E_32630 18423397 32630 ucccaguccaccg ............. ............. A 3'-OH, 2',5'-phosphodiester substitution in the hairpin ribozyme active site reveals similarities with protein ribonucleases; 13-mer substrate strand with 3'-OH, 2',5'-phosphodiester covalently linking 5th and 6th nucleotides 3cqs B 30 2.8 URS000080E2DF_32630 18423397 32630 cggugagaagggnggcagagaaacacacga .............................. .............................. A 3'-OH, 2',5'-phosphodiester substitution in the hairpin ribozyme active site reveals similarities with protein ribonucleases; 29-mer ribozyme strand with S9L synthetic linker at 13th position 3cqs C 19 2.8 URS000080E34C_32630 18423397 32630 ucgugguacauuaccugcc ................... ................... A 3'-OH, 2',5'-phosphodiester substitution in the hairpin ribozyme active site reveals similarities with protein ribonucleases; 19-mer ribozyme strand 3cr1 A 13 2.25 URS000080E09E_32630 18596253 32630 ucccnguccaccg ............. ............. crystal structure of a minimal, mutant, all-RNA hairpin ribozyme (A38C, A-1OMA) grown from MgCl2; RNA (5'-R(*UP*CP*CP*CP*(A2M)P*GP*UP*CP*CP*AP*CP*CP*G)-3') 3cr1 B 30 2.25 URS000080E2DF_32630 18596253 32630 cggugagaagggnggcagagaaacacacga .............................. .............................. crystal structure of a minimal, mutant, all-RNA hairpin ribozyme (A38C, A-1OMA) grown from MgCl2; loop A and B ribozyme strand 3cr1 C 19 2.25 URS000080DFE2_32630 18596253 32630 ucgugguccauuaccugcc ................... ................... crystal structure of a minimal, mutant, all-RNA hairpin ribozyme (A38C, A-1OMA) grown from MgCl2; RNA (5'-R(*UP*CP*GP*UP*GP*GP*UP*CP*CP*AP*UP*UP*AP*CP*CP*UP*GP*CP*C)-3') 3cxc 0 2754 3.0 RF02540,RF00002 URS000080DFCD_2238 18947996 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagccauggggagccgcacggaggcgaagaaccauggauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaaugugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucucgacgaagucucuuggaacagagcgugauacagggugacaaccccguacucgagaccaguacgacgugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccucgacgaaugaccgacgcgcgagcguccaguaagacucacgggaagccgauguucugucguacguuuugaaaaacgagccagggagugugucugcauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgccguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaaguaggggugaaaacuccuauggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucauaccgcaacucgacuaugacgaaaugggaaacggguuaauauucccgugccacuaugcagugaaaguugacgcccuggggucgaucacgcugggcaucgcccagucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcauaguguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcgaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggcuaucucagccggggacccggcgaagagugcaagagcaaaagauagcuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugagguuguucgccuauuaaaggaggucgugagcuggguuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa 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The structure of an enhanced oxazolidinone inhibitor bound to the 50S ribosomal subunit of H. marismortui; 23S RIBOSOMAL RNA 3cxc 9 122 3.0 RF00001 URS00003592C7_2238 18947996 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccggggaguacuggagugcgcgagccucugggaaacccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<<.............>>>>..>>....>>>>>>.>><..<<<<<.....<<<<<<.<<....>>>>>>>>....>>>>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...(((((.....((((((.((....))))))))....)))))...))))))... The structure of an enhanced oxazolidinone inhibitor bound to the 50S ribosomal subunit of H. marismortui; 5S RIBOSOMAL RNA 3cz3 E 19 3.23 URS000080E1D9_32630 32630 cguacgcggaauacuucga ................... ................... Crystal structure of Tomato Aspermy Virus 2b in complex with siRNA; RNA (5'-R(P*CP*GP*UP*AP*CP*GP*CP*GP*GP*AP*AP*UP*AP*CP*UP*UP*CP*GP*A)-3') 3cz3 F 19 3.23 URS000080DE45_32630 32630 ucgaaguauuccgcguacg ................... ................... Crystal structure of Tomato Aspermy Virus 2b in complex with siRNA; RNA (5'-R(P*UP*CP*GP*AP*AP*GP*UP*AP*UP*UP*CP*CP*GP*CP*GP*UP*AP*CP*G)-3') 3cz3 G 19 3.23 URS000080E1D9_32630 32630 cguacgcggaauacuucga ................... ................... Crystal structure of Tomato Aspermy Virus 2b in complex with siRNA; RNA (5'-R(P*CP*GP*UP*AP*CP*GP*CP*GP*GP*AP*AP*UP*AP*CP*UP*UP*CP*GP*A)-3') 3cz3 H 19 3.23 URS000080DE45_32630 32630 ucgaaguauuccgcguacg ................... ................... Crystal structure of Tomato Aspermy Virus 2b in complex with siRNA; RNA (5'-R(P*UP*CP*GP*AP*AP*GP*UP*AP*UP*UP*CP*CP*GP*CP*GP*UP*AP*CP*G)-3') 3czw X 15 1.4 URS000080DF69_32630 18658118 32630 uggucugaugaggcc ............... ............... X-ray structures of the (GUGGUCUGAUGAGGCC) RNA duplex; RNA (5'-R(*G*UP*GP*GP*UP*CP*UP*GP*AP*UP*GP*AP*GP*GP*CP*C)-3') 3d0m X 16 2.0 URS000080DF69_32630 18658118 32630 guggucugaugaggcc ................ ................ X-ray structures of the (GUGGUCUGAUGAGGCC) RNA duplex; RNA (5'-R(*GP*UP*GP*GP*UP*CP*UP*GP*AP*UP*GP*AP*GP*GP*CP*C)-3') 3deg A 76 10.9 RF00005 URS000011107D_562 19172743 0030533 0006412 562 gcggauuuancucagnngggagagcnccaganunaagaunuggagnucnugugnucgnuccacagaauucgcacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((.........)))).....(((((..]....)))))))))))).... Complex of elongating Escherichia coli 70S ribosome and EF4(LepA)-GMPPNP; A/L-tRNA 3deg E 16 10.9 URS000080DD6A_562 19172743 562 cuacuggaaacgguag <<<<<......>>>>> ((((((....)))))) Complex of elongating Escherichia coli 70S ribosome and EF4(LepA)-GMPPNP; 30S RNA helix 8 3deg F 12 10.9 URS000080E32A_562 19172743 562 cuccuacgggag <<<<<..>>>>> ((((....)))) Complex of elongating Escherichia coli 70S ribosome and EF4(LepA)-GMPPNP; 30S RNA helix 14 3deg J 18 10.9 URS000080DDB3_562 19172743 562 ugucggguaaguuccgac .<<<<<<.....>>>>>> .(((((.......))))) Complex of elongating Escherichia coli 70S ribosome and EF4(LepA)-GMPPNP; 50S RNA helix 71 3deg K 15 10.9 URS000080DE4D_562 19172743 562 auggcuguucgccau <<<<<.....>>>>> (((((.....))))) Complex of elongating Escherichia coli 70S ribosome and EF4(LepA)-GMPPNP; 50S RNA helix 92 3dkn D 20 8.7 URS000080DE98_9615 18611385 9615 cgugccaagcugcgauaagc <<<........>>>...... (((........)))...... Sec61 in the Canine ribosome-channel complex from the endoplasmic reticulum; RNA (5'-R(P*CP*GP*UP*GP*CP*CP*AP*AP*GP*CP*UP*GP*CP*GP*AP*UP*AP*AP*GP*C)-3') 3dkn E 17 8.7 URS000080E109_9615 18611385 9615 agccgcacggaggcgaa .<<<.......>>>... .(((.......)))... Sec61 in the Canine ribosome-channel complex from the endoplasmic reticulum; RNA (5'-R(P*AP*GP*CP*CP*GP*CP*AP*CP*GP*GP*AP*GP*GP*CP*GP*AP*A)-3') 3dll X 2686 3.5 RF02540,RF02541 URS000080DEF1_1299 18757750 0003735 0005840 1299 ggucaagauaguaaggguccacgguggaugcccuggcgcuggagccgaugaaggacgcgauuaccugcgaaaagccccgacgagcuggagauacgcuuugacucggggauguccgaauggggaaacccaccucguaagagguauccgcaaggaugggaacucagggaacugaaacaucucaguaccugaaggagaagaaagagaauucgauuccguuaguagcggcgagcgaacccggaucagcccaaucaagccgaaguggcuggaaagcuacaccucagaaggugagaguccuguaggcgaacgagaggucguuguucgugaaacgaugacugaauccgcgcggaccaccgcgcaaggcuaaauacucccagugaccgauagcgcauaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaagagaaccugaaaccguggacuuacaagcagucauggcaccuuaugcguguuauggcgugccuauugaagcaugagccggcgacuuagaccugacgugcgagcuuaaguugaaaaacggaggcggagcgaaagcgaguccgaauagggcggcauuaguacgucgggcuagacucgaaaccaggugagcuaagcaugaccagguugaaacccccgugacagggggcggaggaccgaaccggugccugcugaaacagucucggaugaguuguguuuaggagugaaaagcuaaccgaaccuggagauagcuaguucuccccgaaauguauugagguacagccucggauguugaccauguccuguagagcacucacaaggcuaaaaccuuaugaaacuccgaaggggcacgcguuuaguccgggagugaggcugcgagagcuaacuuccguagccgagagggaaacaacccagaccaucagcuaaggucccuaaaugaucgcucagugguuaaggaugugucgucgcauagacagccaggagguuggcuuagaagcagccacccuucaaagagugcguaauagcucacuggucgagugacgaugcgccgaaaaugaucggggcucaagugaucuaccgaagcuauggauucaacucgcgaagcgaguugucugguaggggagcguucaguccgcggagaagccauaccggaaggagugguggagccgacugaagugcggaugccggcaugaguaacgauaaaagaagugagaaucuucuucgccguaaggacaaggguuccuggggaagggucguccgcccagggaaagucgggaccuaaggugaggccgaacggcgcagccgauggacagcaggucaagauuccugcaccgaucauguggagugauggagggacgcauuacgcuauccaaugccaagcuauggcuaugcugguugguacgcucaagggcgaucgggucagaaaaucuaccggucacaugccucagacguaucgggagcuuccucggaagcgaaguuggaaacgcgacggugccaagaaaagcuucuaaacguugaaacaugauugcccguaccgcaaaccgacacagguguccgagugucaaugcacuaaggcgcgcgagagaacccucguuaaggaacuuugcaaucucaccccguaacuucggaagaagggguccccacgcuucgcguggggcgcagugaauaggcccaggcgacuguuuaccaaaaucacagcacucugccaacacgaacaguggacguauagggugugacgccugcccggugccggaaggucaaguggagcggugcaagcugcgaaaugaagccccggugaacggcuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaggcguaacgaucugggcgcugucucaacgagggacucggugaaauugaauuggcuguaaagaugcggccuacccguagcaggacgaaaagaccccguggagcuuuacuauagucuggcauugggauucggguuucuagaaacuuggauuucuaaccugaaaaaucacuuucggggaccgugcuuggcggguaguuugacuggggcggucgccucccaaaauguaacggaggcgcccaaaggucaccucaagacgguuggaaaucgucuguagagcgcaaagguagaagguggcuugacugcgagacugacacgucgagcagggaggaaacucgggcuuagugaaccggugguaccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagaguccauaucggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgcuacgggcgcaggagaauugaggggaguugcuccuaguacgagaggaccggagugaacggaccgcuggucucccugcugucguaccaacggcacaugcaggguagcuauguccggaacggauaaccgcugaaagcaucuaagcgggaagccagccccaagaugaguucucccacuguuuaucagguaagacucccggaagaccaccggguuaagaggccaggcgugcacgcauagcaauguguucagcggacuggugcucaucagucgaggucuugacca 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((((((((......((((((((((.....(((..(((.((((((((......((((((.[[..[[.))).....((((((...((.]]..]]..))......))))))...)))....(((....)))(((((....)))))((((....))))))...((((((.....(......)......))))).).........((....))...((((......((.....)).....))))...(((...((..(((...(((((......)))))[[(...).(((.....]])))...)))....))..(((((((((.[.....)))))))))......(((((].[[[[)))))..)))......)).)))).).))..............((....))....))......(..((((....))))............)).....)))))))))).....(.((((((((((.......)))))))))).[.(.(........).).((((((....(((.((((((((((..(((...(((....)))...)))...((....))...((......)).........)))))))))))))..((.(...((((((.....((((((((((.((((....(((((......)))))....)[)))...(((..(.((........)).).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((..(((((.((((((.(.(((...(((.((((......)))).)))..)).)..))))))).).))).)))))))).))..(((((((.((......)).)))))))....(((......)))...((((.(((...((([[[...(.(((((((....(.....((..((((((((((........((((.(((..(((.........)))..))).....(...((......)).).))))....)))))))))).))..........]]].)..).))))))))))...)))))))...((((((((...)))))))).......))))))(.(((((((.((......(((((.((....)).)))))...)).)))))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((....(...((((....(((((.(((..(((((.((((.((...{{....))))))(((((((.((..((((((((((...((.....)).))))))....))))..)))))))))...(((((....)))))....)))))...)))..)))))(..).....))))...).......))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((...))))))))(...).......(((((((((.].(...........)...(((((((.....(((.....))).......))))))).}((((.(((..((.((((..(((...((...((((......))))...))...)))))))...))))).......((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((()))))))))))))))...(((((((......)))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...)..(][.[[[).....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))....((....((((.............))))....))..))))..]....)))))))(.((.......))....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))...))))))))). The oxazolidinone antibiotics perturb the ribosomal peptidyl-transferase center and effect tRNA positioning; rRNA-23S ribosomal RNA 3dll Z 122 3.5 RF00001 URS000080E04E_1299 18757750 0003735 0005840 1299 cacccccgugcccauagcacuguggaaccaccccaccccaugccgaacugggucgugaaacacagcagcgccaaugauacucggaccgcagggucccggaaaagucggucagcgcggggguu .<<<<<<<<<<.....<<.<<<<<....<<<<<<<.............>>>>..>>>...>>>>>..>><<<.......<<.<<<<<....>>>>>.>>.......>>>..>>>>>>>>>>. .((((((((((.....((.(((((.....((((((.............))))..))....)))))..)).((.......((.(((((....))))).)).......))...)))))))))). The oxazolidinone antibiotics perturb the ribosomal peptidyl-transferase center and effect tRNA positioning; rRNA-5S ribosomal RNA 3dvv A 23 2.0 URS000080E167_32630 32630 cungcugaagugcacacagcaag ....................... ....................... Crystal structure of HIV-1 subtype F DIS extended duplex RNA bound to ribostamycin (U267OMe); HIV-1 genomic RNA 3dvv B 23 2.0 URS000080E167_32630 32630 cungcugaagugcacacagcaag ....................... ....................... Crystal structure of HIV-1 subtype F DIS extended duplex RNA bound to ribostamycin (U267OMe); HIV-1 genomic RNA 3egz B 65 2.2 URS000080E272_32630 18940672 32630 gagggagaggugaagaauacgaccaccuagguaccauugcacuccgguaccuaaaacauacccuc <<<<<...<<<<...........>>>><<<<<<<<..........>>>>>>>>.......>>>>> (((((...((((...........))))((((((((..........)))))))).......))))) Crystal structure of an in vitro evolved tetracycline aptamer and artificial riboswitch; Tetracycline aptamer and artificial riboswitch 3eog A 388 3.391 RF02001,RF01998 URS000080DD31_182710 18953333 0000373 182710 gugcccggcaugggugcagucuauagggugagagucccgaacugugaaggcagaaguaacaguuagccuaacgcaaggguguccguggcgacauggaaucugaaggaagcggacggcaaaccuucggucugaggaacacgaacuucauaugaggcuagguaucaauggaugaguuugcauaacaaaacaaaguccuuucugccaaaguugguacagaguaaaugaagcagauugaugaagggaaagacugcauucuuacccggggaggucuggaaacagaagucagcagaagucauaguacccuguucgcaggggaaggacggaacaaguauggcguucgcgccuaagcuugaaccgccguauaccgaacgguacguacgguggugug {..<<<<<...<<<<<<<<<<<...<<<.......>>>..(((((...<<<<<<<...)))))..<<<...<<<..<<<<.<<<<<<....>>>>>>>>>>.......>>>...>>>...(((((((((((...........(((((......[[[.....(((((<<<<..<<<<........>>>>...>>>>.>>>>>>>...))))).....]]]...))))))))))...))))))...>>>>>>>>>>>...}>>>>>....<<<<....>>>>...........<<.......<<.<......>>>......>>....<<<<<..<<<<....>>>>...>>>>>.<<<<<<<<<<<<<....>>>..>>>>>>>>>>... [<.((((({..(((((((((((...(((.......)))..(((((..A.[[[[[[...)))))..(((...(((..((((.((((((....))))))))))...>}..)))...)))...(((((((((((...........(((((......(((..(...((((((((..((((........))))...))))a]]]]]]....))))...)..)))...))))))))))...))))))...)))))))))))...])))))(...((((....))))...)...........(....(.(((....))))....).......(((((..((((....))))...))))).(((((((((((((....)))..))))))))))... Co-crystallization showing exon recognition by a group II intron; Group IIC intron 3eoh A 381 3.125 RF02001,RF01998 URS000080DD31_182710 18953333 0000373 182710 gugcccggcaugggugcagucuauagggugagagucccgaacugugaaggcagaaguaacaguuagccuaacgcaaggguguccguggcgacauggaaucugaaggaagcggacggcaaaccuucggucugaggaacacgaacuucauaugaggcuagguaucaauggaugaguuugcauaacaaaacaaaguccuuucugccaaaguugguagaguaaaugaagcagauugaugaagggaaagacugcauucuuacccggggaggucuggaaacagaagucagcagaagucauaguacccucaggggaaggacggaacaaguauggcguucgcgccuaagcuugaaccgccguauaccgaacgguacguacgguggugug {..<<<<<...<<<<<<<<<<<...<<<.......>>>..(((((...<<<<<<<...)))))..<<<...<<<..<<<<.<<<<<<....>>>>>>>>>>.......>>>...>>>...(((((((((((...........(((((......[[[.....(((((<<<<..<<<<........>>>>...>>>>.>>>>>>>...)))))...]]]...))))))))))...))))))...>>>>>>>>>>>...}>>>>>....<<<<....>>>>...........<<<......<<....>>.....>>>....<<<<<..<<<<....>>>>...>>>>>.<<<<<<<<<<<<<....>>>..>>>>>>>>>>... [<.((((({..(((((((((((...(((.......)))..(((((..A.[[[[[[...)))))..(((...(((..((((.((((((....))))))))))...>}.{)))...)))...(((((((((((...........(((((.....[(((......((((((((..((((.]......))))...))))a]]]]]]....))))....)))...))))))))))...))))))...))))))))))).}.])))))(...((((....))))...).......((..(....((.....))...).))....(((((..((((....))))...))))).(((((((((((((....)))..))))))))))... Refined group II intron structure; Group IIC intron 3f4e X 54 3.05 RF00050 URS000080DF4D_32630 19169240 0010181 32630 ggaucuucggggcagggugaaauucccgaccggugguauaguccacgaaagcuu ..............<<<.......>>>.....<<<<......>>>>........ ..............(((.......))).....((((......))))........ Crystal structure of the FMN riboswitch bound to FMN, split RNA.; FMN riboswitch 3f4e Y 56 3.05 RF00050 URS000080E20B_32630 19169240 0010181 32630 gcuuugauuuggugaaauuccaaaaccgacaguagagucuggaugagagaagauuc .......<<<<<.......>>>>>.....<<<......>>>............... .......(((((.......))))).....(((......)))............... Crystal structure of the FMN riboswitch bound to FMN, split RNA.; FMN riboswitch 3f4g X 54 3.01 RF00050 URS000080DF4D_32630 19169240 0010181 32630 ggaucuucggggcagggugaaauucccgaccggugguauaguccacgaaagcuu ..............<<<.......>>>.....<<<<......>>>>........ ..............(((.......))).....((((......))))........ Crystal structure of the FMN riboswitch bound to riboflavin.; FMN riboswitch 3f4g Y 56 3.01 RF00050 URS000080E20B_32630 19169240 0010181 32630 gcuuugauuuggugaaauuccaaaaccgacaguagagucuggaugagagaagauuc .......<<<<<.......>>>>>.....<<<......>>>............... .......(((((.......))))).....(((......)))............... Crystal structure of the FMN riboswitch bound to riboflavin.; FMN riboswitch 3f4h X 54 3.0 RF00050 URS000080DF4D_32630 19169240 0010181 32630 ggaucuucggggcagggugaaauucccgaccggugguauaguccacgaaagcuu ..............<<<.......>>>.....<<<<......>>>>........ ..............(((.......))).....((((......))))........ Crystal structure of the FMN riboswitch bound to roseoflavin; FMN riboswitch 3f4h Y 56 3.0 RF00050 URS000080E20B_32630 19169240 0010181 32630 gcuuugauuuggugaaauuccaaaaccgacaguagagucuggaugagagaagauuc .......<<<<<.......>>>>>.....<<<......>>>............... .......(((((.......))))).....(((......)))............... Crystal structure of the FMN riboswitch bound to roseoflavin; FMN riboswitch 3far A 23 2.4 URS000080DD3F_32630 32630 cuugcugaagcgcgcacggcaag ....................... ....................... Cation-dependent self-cleavage activity in the duplex form of the subtype-B HIV-1 RNA Dimerization Initiation Site; RNA (5'-R(*CP*UP*UP*GP*CP*UP*GP*AP*AP*GP*CP*GP*CP*GP*CP*AP*CP*GP*GP*CP*AP*AP*G)-3') 3far B 23 2.4 URS000080DD3F_32630 32630 cuugcugaagcgcgcacggcaag ....................... ....................... Cation-dependent self-cleavage activity in the duplex form of the subtype-B HIV-1 RNA Dimerization Initiation Site; RNA (5'-R(*CP*UP*UP*GP*CP*UP*GP*AP*AP*GP*CP*GP*CP*GP*CP*AP*CP*GP*GP*CP*AP*AP*G)-3') 3fs0 A 10 2.3 URS000080DE68_32630 19220054 32630 ggugaggcug .......... .......... Class II ligase ribozyme product-template duplex, structure 2; 5'-R(*GP*GP*UP*GP*AP*GP*GP*CP*UP*G)-3' 3fs0 B 11 2.3 URS000080E1F1_32630 19220054 32630 ccagucggaac ........... ........... Class II ligase ribozyme product-template duplex, structure 2; 5'-R(*CP*CP*AP*GP*UP*CP*GP*GP*AP*AP*C)-3' 3fte C 22 3.0 URS000080E0D3_32630 19278652 32630 aaccguaggggaaccugcgguu ...................... ...................... Crystal structure of A. aeolicus KsgA in complex with RNA; 5'-R(P*AP*AP*CP*CP*GP*UP*AP*GP*GP*GP*GP*AP*AP*CP*CP*UP*GP*CP*GP*GP*UP*U)-3' 3fte D 22 3.0 URS000080E0D3_32630 19278652 32630 aaccguaggggaaccugcgguu ...................... ...................... Crystal structure of A. aeolicus KsgA in complex with RNA; 5'-R(P*AP*AP*CP*CP*GP*UP*AP*GP*GP*GP*GP*AP*AP*CP*CP*UP*GP*CP*GP*GP*UP*U)-3' 3ftf C 22 2.8 URS000080E0D3_32630 19278652 32630 aaccguaggggaaccugcgguu ...................... ...................... Crystal structure of A. aeolicus KsgA in complex with RNA and SAH; 5'-R(P*AP*AP*CP*CP*GP*UP*AP*GP*GP*GP*GP*AP*AP*CP*CP*UP*GP*CP*GP*GP*UP*U)-3' 3ftf D 22 2.8 URS000080E0D3_32630 19278652 32630 aaccguaggggaaccugcgguu ...................... ...................... Crystal structure of A. aeolicus KsgA in complex with RNA and SAH; 5'-R(P*AP*AP*CP*CP*GP*UP*AP*GP*GP*GP*GP*AP*AP*CP*CP*UP*GP*CP*GP*GP*UP*U)-3' 3ftm A 11 2.7 URS000080DFC7_32630 19220054 32630 gugugaggcug ........... ........... Class II ligase ribozyme product-template duplex, structure 1; 5'-R(*GP*UP*GP*UP*GP*AP*GP*GP*CP*UP*G)-3' 3ftm B 12 2.7 URS000080DE7B_32630 19220054 32630 ccagucggaaca ............ ............ Class II ligase ribozyme product-template duplex, structure 1; 5'-R(*CP*CP*AP*GP*UP*CP*GP*GP*AP*AP*CP*A)-3' 3ftm C 11 2.7 URS000080DFC7_32630 19220054 32630 gugugaggcug ........... ........... Class II ligase ribozyme product-template duplex, structure 1; 5'-R(*GP*UP*GP*UP*GP*AP*GP*GP*CP*UP*G)-3' 3ftm D 12 2.7 URS000080DE7B_32630 19220054 32630 ccagucggaaca ............ ............ Class II ligase ribozyme product-template duplex, structure 1; 5'-R(*CP*CP*AP*GP*UP*CP*GP*GP*AP*AP*CP*A)-3' 3fwo A 2765 3.71 RF02540,RF02541 URS000080DEF1_243230 0003735 0005840 243230 ggucaagauaguaaggguccacgguggaugcccuggcgcuggagccgaugaaggacgcgauuaccugcgaaaagccccgacgagcuggagauacgcuuugacucggggauguccgaauggggaaacccaccucguaagagguauccgcaaggaugggaacucagggaacugaaacaucucaguaccugaaggagaagaaagagaauucgauuccguuaguagcggcgagcgaacccggaucagcccaaauucaaccccucaagccgaaguggcuggaaagcuacaccucagaaggugagaguccuguaggcgaacgagcgguugacuguaaggucguuguucgugaaacgaugacugaauccgcgcggaccaccgcgcaaggcuaaauacucccagugaccgauagcgcauaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaagagaaccugaaaccguggacuuacaagcagucauggcaccuuaugcguguuauggcgugccuauugaagcaugagccggcgacuuagaccugacgugcgagcuuaaguugaaaaacggaggcggagcgaaagcgaguccgaauagggcggcauuaguacgucgggcuagacucgaaaccaggugagcuaagcaugaccagguugaaacccccgugacagggggcggaggaccgaaccggugccugcugaaacagucucggaugaguuguguuuagagugaaaagcuaaccgaaccuggagauagcuaguucuccccgaaauguauugagguacagccucggauguugaccauguccuguagagcacucacaaggcuaaaaccuuaugaaacuccgaaggggcacgcguuuaguccgggagugaggcugcgagagcuaacuuccguagccgagagggaaacaacccagaccaucagcuaaggucccuaaaugaucgcucagugguuaaggaugugucgucgcauagacagccaggagguuggcuuagaagcagccacccuucaaagagugcguaauagcucacuggucgagugacgaugcgccgaaaaugaucggggcucaagugaucuaccgaagcuauggauucaacucgcgaagcgaguugucugguaggggagcguucaguccgcggagaagccauaccggaaggagugguggagccgacugaagugcggaugccggcaugaguaacgauaaaagaagugagaaucuucuucgccguaaggacaaggguuccuggggaagggucguccgcccagggaaagucgggaccuaaggugaggccgaacggcgcagccgauggacagcaggucaagauuccugcaccgaucauguggagugauggagggacgcauuacgcuauccaaugccaagcuauggcuaugcugguugguacgcucaagggcgaucgggucagaaaaucuaccggucacaugccucagacguaucgggagcuuccucggaagcgaaguuggaaacgcgacggugccaagaaaagcuucuaaacguugaaacaugauugcccguaccgcaaaccgacacagguguccgagugucaaugcacuaaggcgcgcgagagaacccucguuaaggaacuuugcaaucucaccccguaacuucggaagaagggguccccacgcuucgcguggggcgcagugaauaggcccaggcgacuguuuaccaaaaucacagcacucugccaacacgaacaguggacguauagggugugacgccugcccggugccggaaggucaaguggagcggugcaagcugcgaaaugaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaggcguaacgaucugggcgcugucucaacgagggacucggugaaauugaauuggcuguaaagaugcggccuacccguagcaggacgaaaagaccccguggagcuuuacuauagucuggcauugggauucggguuucucugcguaggugggagaaacuggccggucgguggccacccugagaaacuuggauuucuaaccugaaaaaucacuuucggggaccgugcuuggcggguaguuugacuggggcggucgccucccaaaauguaacggaggcgcccaaaggucaccucaagacgguuggaaaucgucuguagagcgcaaagguagaagguggcuugacugcgagacugacacgucgagcagggaggaaacucgggcuuagugaaccggugguaccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagaguccauaucggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgcuacgggcgcaggagaauugaggggaguugcuccuaguacgagaggaccggagugaacggaccgcuggucucccugcugucguaccaacggcacaugcaggguagcuauguccggaacggauaaccgcugaaagcaucuaagcgggaagccagccccaagaugaguucucccacuguucagguaagacucccggaagaccaccggguuaagaggccaggcgugcacgcauagcaauguguucagcggacuggugcucaucagucgaggucuugacca <<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<<((..((>>>>.....<<<<<<...<<.))..))..>>......>>>>>>...>>>....<<<....>>><<<<<....>>>>><<<<....>>>>>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<......<<.....>>.....>>>>...<<<.....<<<<<<..<<..<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>....>>..>>>>>>......<<<<.<<<.........>>>.>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>..............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<.......>>>>>>>>>>...<.<........>.>.<<<<<<....<<<.<<<<<<<<<<...<.................>.....<<....>>...<<......>>.........>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<.....<<<<........>>>>......>>>...<<<..<.<<<......>>>.>.>>>....>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<...<..<.<<<<<<...<<<...<<<.<<<<......>>>>.>>>..>>.>...>>>>>>.>...>..>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<..........<<<<<.<<......<.......>......>>......................>>>>>......>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>>..<.<...<.......>..>.>.......>>>>>><<<<<<<<<.<<......<<<<<.<<....>>.>>>>>...>>.>>>>>>>.>>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<<..>>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<...<<...<<......<<<<..<<<..<<<<<.<<<<.<<...[[....>>>>>>.<...<<.<..<<<..<<<<<<.............>>>>>>.....>>>..>.>>..>.....<<<<......>>>>....>>>>>...>>>...>>>>..........>>....>>......>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<<..............<<<<<...............>>>>><<<<<<<<...>>>>>>>>............<<<<<<<<<..<<...........>>..<<<<<<<.....<<<.....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<....<<<<......>>>>....>...>>>>>>>>..>>>>>.<<<.<.......>.>>>.........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>....>>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<......<............<...........<<>>........>........>......>>>>>>...<<<<<<........>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<<.....>>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.]].>>>>>>...>>>>>...>>>>.>>>>>....<<.<..<<<<.............>>>>...>>>..>>>>.......>>>>>>>..<<....>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>>>. ((((((((......((((((((((.....(((..(((.((((((((.(....(((.((.[...[[[))...]..((((((...((.]]...]..))......))))))...)))...)(((....)))(((((....)))))((((....))))))...((((((.....(......)......))))).).........((....))...((((......((.....)).....))))...(((.....((((((..((..(((...(((((......)))))[[(...).(((.....]])))...)))....))..))))))......((((.((((.......)))).))))......(((((..[[[[)))))..)))......)).)))).).))..............((....))....))......(..((((....))))............)).....)))))))))).......(((((.((((.......)))).))))).[.(.(........).).((((((....(((.((((((((((.........((....))..........((....))....(......)..........)))))))))))))..((.(...((((((.....((.((.(((..((((....((((........))))....)[)))...((...(.(((......))).)..))....))).)).))..(((.....)))......))))))......).))..((((((....((((......))))(((((((((...((.(.((.((....(((...(((.((((......)))).)))..)).)....)).)).)..))..))))))).))..(((((((.((......)).)))))))....(((......)))...((((.(((...((([[[...(.((((.((....(.....((..(((((((..........(((((.(((..(.(.........).)..))).....(...(........).).)))).).....))))))).))..........]]].)..).).))))))))...)))))))....(..((((...))))..)........))))))(.(((((((.((......((((..((....))..))))...)).)))))))..).....))))))(......((.....((((((.......))))))((((....((((..((...((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](.(((((((...((.....((....(((((.(((..(((((..(((.((...{{....)))))....(.((.....((..((.(((....(.....)..))).)).....)).....)).)......(((((....)))))....)))))...)))..)))))(..).....)).....))......))))))).)))))..)).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((...))))))))(...).......((((((.((.].(...........)...(((((((.....(((.....))).......))))))).}((((.(((..((.((((..(((...((...((.(......).))...))...)))))))...)))))(.((((......).))).)........((..........(((((.......)))))..)..)....))))...))..)))))).)..))).)))))))).)))))).....).....(((.(....{]..).)))..((((((((.(((..(......((((.((((((..(((((.(.(.((((..(((((.(..(.((((..(....(..(.........(.(()).)......)..))..))).))..).)))))...(((((((......))))))).....)))).).)..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....((.((((.((..]]]]..)))))).)).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).)})......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....)...)))))))))))[...(((((((...((((..(((((((...............))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))....((....((((.............))))....))..))))..]....)))))))..((....))....(((((((((.......)))))....(((.((((.(((....(((((....)))))...)))..))))..)))...))))....)))))))). The large ribosomal subunit from Deinococcus radiodurans complexed with Methymycin; 23S RIBOSOMAL RNA 3fwo B 118 3.71 RF00001 URS000080DF5C_243230 0003735 0005840 243230 cccccgugcccauagcacuguggaaccaccccaccccaugccgaacugggucgugaaacacagcagcgccaaugauacucggaccgcagggucccggaaaagucggucagcgcggggg <<<<<<<<<.....<<.<<<<<....<<<<<<<.............>>>>..>>>...>>>>>..>><<<.......<<.<<<<<....>>>>>.>>.......>>>..>>>>>>>>> ((((((.((.....((.(((((....((((((....(.....)....)))..)))...)))))..))(((.....(.((.(((((....))))).)).).....)))..)).)))))) The large ribosomal subunit from Deinococcus radiodurans complexed with Methymycin; 5S RIBOSOMAL RNA 3g4s 0 2754 3.2 RF02540,RF00002 URS000080E102_2238 19362093 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagcuguggggagccgcacggaggcgaagaaccacagauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaacgugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucuucacgaagucucuuggaauagagcgugauacagggugacaaccccguacugaagaccaguacgcugugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccuugacgaaugaccgagacgcgagucuccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucuguauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgcuguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaagcaggggcgagagcuccuguggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucucaccgcaacucgacugagacgaaaugggaaacagguuaauauuccugugccaucaugcagugaaaguugacgcccuggggucgaucacgccgggcaucgcccggucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcaugauguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcgaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggucaucucagccggggacccggcgaagagugcaagagcaaaagaugacuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcugggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>...<<<<<.....<<.....>>....>>>>>...<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<<<<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>>>>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<.<<<....<....<<<<<....>>>>>.....>...>>>.>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<<<<<.....>>>>>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<....<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<..[[.>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>..>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<...........>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......((((.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......))))...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......(...(((.....))).............)).....)))))))))......(.((((((((((....((((((.(((....(....(((((....))))).....)...))).))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....)).....((((...((((..))))...)))).((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(.(..(((.........)))...))........((........))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)......))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))..(((((((.....)))))))..(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((.(..((((.............))))...)))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Co-crystal structure of Tiamulin bound to the large ribosomal subunit; 23S ribosomal RNA 3g4s 9 122 3.2 RF00001 URS00000A7E81_2238 19362093 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccagggaguacuggagugcgcgagccucugggaaauccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<.<<.....<<<<<<.<<....>>>>>>>>....>>.>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...((.(......((((((.((....)))))))).....).))...))))))... Co-crystal structure of Tiamulin bound to the large ribosomal subunit; 5S ribosomal RNA 3g6e 0 2754 2.7 RF02540,RF00002 URS000080E102_2238 19362093 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagcuguggggagccgcacggaggcgaagaaccacagauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaacgugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucuucacgaagucucuuggaauagagcgugauacagggugacaaccccguacugaagaccaguacgcugugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccuugacgaaugaccgagacgcgagucuccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucuguauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgcuguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaagcaggggcgagagcuccuguggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucucaccgcaacucgacugagacgaaaugggaaacagguuaauauuccugugccaucaugcagugaaaguugacgcccuggggucgaucacgccgggcaucgcccggucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcaugauguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcgaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggucaucucagccggggacccggcgaagagugcaagagcaaaagaugacuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcugggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>..<<<<<<.....<<.....>>....>>>>>>..<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<<<<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>>>>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<.<<<.........<<<<<....>>>>>.........>>>.>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<<<<<.....>>>>>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<....<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>..>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......((((.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......))))...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((.(((....(....(((((....))))).....)...))).))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).).....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Co-crystal structure of Homoharringtonine bound to the large ribosomal subunit; 23S ribosomal RNA 3g6e 9 122 2.7 RF00001 URS00000A7E81_2238 19362093 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccagggaguacuggagugcgcgagccucugggaaauccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<.<<.....<<<<<<.<<....>>>>>>>>....>>.>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...((.(......((((((.((....)))))))).....).))...))))))... Co-crystal structure of Homoharringtonine bound to the large ribosomal subunit; 5S ribosomal RNA 3g71 0 2754 2.85 RF02540,RF00002 URS000080E102_2238 19362093 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagcuguggggagccgcacggaggcgaagaaccacagauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaacgugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucuucacgaagucucuuggaauagagcgugauacagggugacaaccccguacugaagaccaguacgcugugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccuugacgaaugaccgagacgcgagucuccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucuguauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgcuguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaagcaggggcgagagcuccuguggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucucaccgcaacucgacugagacgaaaugggaaacagguuaauauuccugugccaucaugcagugaaaguugacgcccuggggucgaucacgccgggcaucgcccggucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcaugauguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcgaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggucaucucagccggggacccggcgaagagugcaagagcaaaagaugacuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcugggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>...<<<<<.....<<.....>>....>>>>>...<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<<<<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>>>>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<.<<<.........<<<<<....>>>>>.........>>>.>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<<<<<.....>>>>>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<<...<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>.>>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......((((.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......))))...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((.(((....(....(((((....))))).....)...))).))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....)).....((((...((((..))))...)))).((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Co-crystal structure of Bruceantin bound to the large ribosomal subunit; 23S ribosomal RNA 3g71 9 122 2.85 RF00001 URS00000A7E81_2238 19362093 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccagggaguacuggagugcgcgagccucugggaaauccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<.<<.....<<<<<<.<<....>>>>>>>>....>>.>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...((.(......((((((.((....)))))))).....).))...))))))... Co-crystal structure of Bruceantin bound to the large ribosomal subunit; 5S ribosomal RNA 3g78 A 389 2.8 RF02001,RF01998 URS000080DD31_182710 20823550,18388288,18953333 0000373 182710 ugugcccggcaugggugcagucuauagggugagagucccgaacugugaaggcagaaguaacaguuagccuaacgcaaggguguccguggcgacauggaaucugaaggaagcggacggcaaaccuucggucugaggaacacgaacuucauaugaggcuagguaucaauggaugaguuugcauaacaaaacaaaguccuuucugccaaaguugguacagaguaaaugaagcagauugaugaagggaaagacugcauucuuacccggggaggucuggaaacagaagucagcagaagucauaguacccuguucgcaggggaaggacggaacaaguauggcguucgcgccuaagcuugaaccgccguauaccgaacgguacguacgguggugug ....<<<<<...<<<<<<<<<<<...<<<.......>>>..<<<<<...(((((((...>>>>>..<<<...<<<..<<<<.<<<<<<....>>>>>>>>>>.......>>>...>>>...<<<<<<<<<<<...........<<<<<......<<<..<<<<<<<<<<<<..<<<<........>>>>...>>>>.)))))))...>>>>>>>>..>>>...>>>>>>>>>>...>>>>>>...>>>>>>>>>>>....>>>>>....<<<<....>>>>...........<<<......<<<<......>>>>....>>>....<<<<<..<<<<....>>>>...>>>>>.<<<<<<<<<<<<<....>>>..>>>>>>>>>>... .[<.((((({..(((((((((((...(((.......)))..(((((...[[[[[[[...)))))..(((...(((..((((.((((((....))))))))))...>}..)))...)))...(((((((((((.(.....)...(((((.....[(((..(((.((((((((..((((.]......))))...)))).]]]]]]]...)))).)))..)))...))))))))))...))))))...)))))))))))...])))))(...((((....))))...).......(((.(....(((........)))...))))....(((((.(((((....))))..)))))).(((((((((((((....)))..))))))))))... Insight into group II intron catalysis from revised crystal structure; Group II intron 3g8s E 13 3.1 URS000080E2F9_1392 19228039 1392 angcgccagaacu ............. ............. Crystal structure of the pre-cleaved Bacillus anthracis glmS ribozyme; RNA (5'-R(*AP*(A2M)P*GP*CP*GP*CP*CP*AP*GP*AP*AP*CP*U)-3') 3g8s P 141 3.1 RF00234 URS000080E011_1392 19228039 0003824 0010468 1392 ngcaccauugcacuccggugccaguugacgaggugggguuuaucgagauuucggcggaugacucccgguuguucaucacaaccgcaagcuuuuacuuaaaucauuaaggugacuuaguggacaaaggugaaagugugauga .<<<<<..........>>>>>.......(((...<<<<<<..)))..............>>>>>><<<<<<.((((((>>>>>>...<<<<<<<<<....<<<<<<<<....>>>>>>>.>....>>>>>>>>>.)))))) ((((((..........))))))......[[[...((((((..]]]..............))))))((((((.....[[))))))....((((((((.....(((((((....)))))))......))))))))..]].... Crystal structure of the pre-cleaved Bacillus anthracis glmS ribozyme; GLMS RIBOZYME 3g8s F 13 3.1 URS000080E2F9_1392 19228039 1392 angcgccagaacu ............. ............. Crystal structure of the pre-cleaved Bacillus anthracis glmS ribozyme; RNA (5'-R(*AP*(A2M)P*GP*CP*GP*CP*CP*AP*GP*AP*AP*CP*U)-3') 3g8s Q 141 3.1 RF00234 URS000080E011_1392 19228039 0003824 0010468 1392 ngcaccauugcacuccggugccaguugacgaggugggguuuaucgagauuucggcggaugacucccgguuguucaucacaaccgcaagcuuuuacuuaaaucauuaaggugacuuaguggacaaaggugaaagugugauga <<<<<<..........>>>>>>......(((...<<<<<<..)))..............>>>>>><<<<<<...((((>>>>>>...<<<<<<<<<....<<<<<<<<....>>>>>>>.>....>>>>>>>>>.)))).. ((((((..........))))))......[[[...((((((..]]]..............))))))((((((....[[[))))))...(((((((((.....(((((((....)))))))......))))))))).]]]... Crystal structure of the pre-cleaved Bacillus anthracis glmS ribozyme; GLMS RIBOZYME 3g8s G 13 3.1 URS000080E2F9_1392 19228039 1392 angcgccagaacu ............. ............. Crystal structure of the pre-cleaved Bacillus anthracis glmS ribozyme; RNA (5'-R(*AP*(A2M)P*GP*CP*GP*CP*CP*AP*GP*AP*AP*CP*U)-3') 3g8s R 141 3.1 RF00234 URS000080E011_1392 19228039 0003824 0010468 1392 ngcaccauugcacuccggugccaguugacgaggugggguuuaucgagauuucggcggaugacucccgguuguucaucacaaccgcaagcuuuuacuuaaaucauuaaggugacuuaguggacaaaggugaaagugugauga <<<<<<..........>>>>>>......(((...<<<<<<..)))..............>>>>>><<<<<<...((((>>>>>>...<<<<<<<<<....<<<<<<<<....>>>>>>>.>....>>>>>>>>>.)))).. ((((((..........))))))......[[[...((((((..]]]..............))))))((((((....[[[))))))...(((((((((.....(((((((....)))))))......))))))))).]]]... Crystal structure of the pre-cleaved Bacillus anthracis glmS ribozyme; GLMS RIBOZYME 3g8s H 13 3.1 URS000080E2F9_1392 19228039 1392 angcgccagaacu ............. ............. Crystal structure of the pre-cleaved Bacillus anthracis glmS ribozyme; RNA (5'-R(*AP*(A2M)P*GP*CP*GP*CP*CP*AP*GP*AP*AP*CP*U)-3') 3g8s S 141 3.1 RF00234 URS000080E011_1392 19228039 0003824 0010468 1392 ngcaccauugcacuccggugccaguugacgaggugggguuuaucgagauuucggcggaugacucccgguuguucaucacaaccgcaagcuuuuacuuaaaucauuaaggugacuuaguggacaaaggugaaagugugauga <<<<<<..........>>>>>>......(((...<<<<<<..)))..............>>>>>><<<<<<.((((((>>>>>>...<<<<.<<<<....<<<<<<<<....>>>>>>>.>....>>>>.>>>>.)))))) ((((((..........))))))......[[[...((((((..]]]..............))))))((((((..[[[[[))))))...(((...(((.....(((((((....)))))))......)))...))).]]]]]. Crystal structure of the pre-cleaved Bacillus anthracis glmS ribozyme; GLMS RIBOZYME 3g8t E 13 3.0 URS000080E2F9_32630 19228039 32630 angcgccagaacu ............. ............. Crystal structure of the G33A mutant Bacillus anthracis glmS ribozyme bound to GlcN6P; RNA (5'-R(*AP*(A2M)P*GP*CP*GP*CP*CP*AP*GP*AP*AP*CP*U)-3') 3g8t P 141 3.0 RF00234 URS000080E372_32630 19228039 0003824 0010468 32630 ngcaccauugcacuccggugccaguugacgagaugggguuuaucgagauuucggcggaugacucccgguuguucaucacaaccgcaagcuuuuacuuaaaucauuaaggugacuuaguggacaaaggugaaagugugauga <<<<<<..........>>>>>>......(((...<<<<<<..)))..............>>>>>><<<<<<..(((((>>>>>>...<<<<<<<<<<...<<<<<<<<....>>>>>>>.>...>>>>>>>>>>.))))). ((((((..........))))))......[[[...((((((..]]]..............))))))((((((..[[[[[))))))...(((((((((.....(((((((....)))))))......))))))))).]]]]]. Crystal structure of the G33A mutant Bacillus anthracis glmS ribozyme bound to GlcN6P; glmS glucosamine-6-phosphate activated ribozyme 3g8t F 13 3.0 URS000080E2F9_32630 19228039 32630 angcgccagaacu ............. ............. Crystal structure of the G33A mutant Bacillus anthracis glmS ribozyme bound to GlcN6P; RNA (5'-R(*AP*(A2M)P*GP*CP*GP*CP*CP*AP*GP*AP*AP*CP*U)-3') 3g8t Q 141 3.0 RF00234 URS000080E372_32630 19228039 0003824 0010468 32630 ngcaccauugcacuccggugccaguugacgagaugggguuuaucgagauuucggcggaugacucccgguuguucaucacaaccgcaagcuuuuacuuaaaucauuaaggugacuuaguggacaaaggugaaagugugauga <<<<<<..........>>>>>>......(((...<<<<<<..)))..............>>>>>><<<<<<.....((>>>>>>...<<<<<<<<<....<<<<<<<<....>>>>>>>.>....>>>>>>>>>.)).... ((((((..........))))))......[[[...((((((..]]]..............))))))((((((......[))))))...(((((((((.....(.(((((....))))).)......))))))))).]..... Crystal structure of the G33A mutant Bacillus anthracis glmS ribozyme bound to GlcN6P; glmS glucosamine-6-phosphate activated ribozyme 3g8t G 13 3.0 URS000080E2F9_32630 19228039 32630 angcgccagaacu ............. ............. Crystal structure of the G33A mutant Bacillus anthracis glmS ribozyme bound to GlcN6P; RNA (5'-R(*AP*(A2M)P*GP*CP*GP*CP*CP*AP*GP*AP*AP*CP*U)-3') 3g8t R 141 3.0 RF00234 URS000080E372_32630 19228039 0003824 0010468 32630 ngcaccauugcacuccggugccaguugacgagaugggguuuaucgagauuucggcggaugacucccgguuguucaucacaaccgcaagcuuuuacuuaaaucauuaaggugacuuaguggacaaaggugaaagugugauga <<<<<<..........>>>>>>......(((...<<<<<<..)))..............>>>>>><<<<<<..(((((>>>>>>...<<<<<<<<<<...<<<<<<<<....>>>>>>>.>...>>>>>>>>>>.))))). ((((((..........))))))......[[[...((((((..]]]..............))))))((((((...[[[[))))))...(((((((((.....(((((((....)))))))......))))))))).]]]].. Crystal structure of the G33A mutant Bacillus anthracis glmS ribozyme bound to GlcN6P; glmS glucosamine-6-phosphate activated ribozyme 3g8t H 13 3.0 URS000080E2F9_32630 19228039 32630 angcgccagaacu ............. ............. Crystal structure of the G33A mutant Bacillus anthracis glmS ribozyme bound to GlcN6P; RNA (5'-R(*AP*(A2M)P*GP*CP*GP*CP*CP*AP*GP*AP*AP*CP*U)-3') 3g8t S 141 3.0 RF00234 URS000080E372_32630 19228039 0003824 0010468 32630 ngcaccauugcacuccggugccaguugacgagaugggguuuaucgagauuucggcggaugacucccgguuguucaucacaaccgcaagcuuuuacuuaaaucauuaaggugacuuaguggacaaaggugaaagugugauga <<<<<<..........>>>>>>......(((...<<<<<<..)))..............>>>>>><<<<<<.((((((>>>>>>...<<<<<<<<<....<<<<<<<<....>>>>>>>.>....>>>>>>>>>.)))))) ((((((..........))))))......[[[...((((((..]]]..............))))))((((((.[[[[[[))))))...((((((((......(....(.......)...).......)))))))).]]]]]] Crystal structure of the G33A mutant Bacillus anthracis glmS ribozyme bound to GlcN6P; glmS glucosamine-6-phosphate activated ribozyme 3g96 E 13 3.01 URS000080E2F9_32630 19228039 32630 angcgccagaacu ............. ............. Crystal structure of the Bacillus anthracis glmS ribozyme bound to MaN6P; RNA (5'-R(*AP*(A2M)P*GP*CP*GP*CP*CP*AP*GP*AP*AP*CP*U)-3') 3g96 P 141 3.01 RF00234 URS000080E011_32630 19228039 0003824 0010468 32630 ngcaccauugcacuccggugccaguugacgaggugggguuuaucgagauuucggcggaugacucccgguuguucaucacaaccgcaagcuuuuacuuaaaucauuaaggugacuuaguggacaaaggugaaagugugauga <<<<<<..........>>>>>>......(((...<<<<<<..)))..............>>>>>><<<<<<.((((((>>>>>>...<<<<<<<<<....<<<<<<<<....>>>>>>>.>....>>>>>>>>>.)))))) ((((((..........))))))......[[[...((((((..]]]..............))))))((((((.[...[[))))))...(((((((((.....(((((((....)))))))......))))))))).]]...] Crystal structure of the Bacillus anthracis glmS ribozyme bound to MaN6P; GLMS RIBOZYME 3g96 F 13 3.01 URS000080E2F9_32630 19228039 32630 angcgccagaacu ............. ............. Crystal structure of the Bacillus anthracis glmS ribozyme bound to MaN6P; RNA (5'-R(*AP*(A2M)P*GP*CP*GP*CP*CP*AP*GP*AP*AP*CP*U)-3') 3g96 Q 141 3.01 RF00234 URS000080E011_32630 19228039 0003824 0010468 32630 ngcaccauugcacuccggugccaguugacgaggugggguuuaucgagauuucggcggaugacucccgguuguucaucacaaccgcaagcuuuuacuuaaaucauuaaggugacuuaguggacaaaggugaaagugugauga <<<<<<..........>>>>>>......(((...<<<<<<..)))..............>>>>>><<<<<<.((((((>>>>>>...<<<<<<<<<....<<<<<<<<....>>>>>>>.>....>>>>>>>>>.)))))) ((((((..........))))))......[[[...((((((..]]]..............))))))((((((..[[[[[))))))...(((((((((.....(((((((....)))))))......))))))))).]]]]]. Crystal structure of the Bacillus anthracis glmS ribozyme bound to MaN6P; GLMS RIBOZYME 3g96 G 13 3.01 URS000080E2F9_32630 19228039 32630 angcgccagaacu ............. ............. Crystal structure of the Bacillus anthracis glmS ribozyme bound to MaN6P; RNA (5'-R(*AP*(A2M)P*GP*CP*GP*CP*CP*AP*GP*AP*AP*CP*U)-3') 3g96 R 141 3.01 RF00234 URS000080E011_32630 19228039 0003824 0010468 32630 ngcaccauugcacuccggugccaguugacgaggugggguuuaucgagauuucggcggaugacucccgguuguucaucacaaccgcaagcuuuuacuuaaaucauuaaggugacuuaguggacaaaggugaaagugugauga <<<<<<..........>>>>>>......(((...<<<<<<..)))..............>>>>>><<<<<<.((((((>>>>>>...<<<<<<<<<....<<<<<<<<....>>>>>>>.>....>>>>>>>>>.)))))) ((((((..........))))))......[[[...((((((..]]]..............))))))((((((..[[[[[))))))...(((((((((.....(((((((....)))))))......))))))))).]]]]]. Crystal structure of the Bacillus anthracis glmS ribozyme bound to MaN6P; GLMS RIBOZYME 3g96 H 13 3.01 URS000080E2F9_32630 19228039 32630 angcgccagaacu ............. ............. Crystal structure of the Bacillus anthracis glmS ribozyme bound to MaN6P; RNA (5'-R(*AP*(A2M)P*GP*CP*GP*CP*CP*AP*GP*AP*AP*CP*U)-3') 3g96 S 141 3.01 RF00234 URS000080E011_32630 19228039 0003824 0010468 32630 ngcaccauugcacuccggugccaguugacgaggugggguuuaucgagauuucggcggaugacucccgguuguucaucacaaccgcaagcuuuuacuuaaaucauuaaggugacuuaguggacaaaggugaaagugugauga <<<<<<..........>>>>>>......(((...<<<<<<..)))..............>>>>>><<<<<<.(((((.>>>>>>...<<<<<<<<<....<<<<<<<<....>>>>>>>.>....>>>>>>>>>..))))) ((((((..........))))))......[[[...((((((..]]]..............))))))((((((..[[[[[))))))...((.(((((......((.((((....)))).)).......))))).)).]]]]]. Crystal structure of the Bacillus anthracis glmS ribozyme bound to MaN6P; GLMS RIBOZYME 3g9c E 11 2.9 URS000080DF1E_32630 19228039 32630 gcgccagaacu ........... ........... Crystal structure of the product Bacillus anthracis glmS ribozyme; RNA (5'-R(*GP*CP*GP*CP*CP*AP*GP*AP*AP*CP*U)-3') 3g9c P 140 2.9 RF00234 URS000080E011_32630 19228039 0003824 0010468 32630 ngcaccauugcacuccggugccaguugacgaggugggguuuaucgagauuucggcggaugacucccgguuguucaucacaaccgcaagcuuuuacuuaaaucauuaaggugacuuaguggacaaaggugaaagugugaug <<<<<<..........>>>>>>......(((...<<<<<<..)))..............>>>>>><<<<<<...((((>>>>>>...<<<<<<<<<....<<<<<<<<....>>>>>>>.>....>>>>>>>>>.)))). ((((((..........))))))......[[[...((((((..]]]..............))))))((((((...[[[[))))))....(...((((.....(((((((....)))))))......))))...)..]]]]. Crystal structure of the product Bacillus anthracis glmS ribozyme; GLMS RIBOZYME 3g9c F 11 2.9 URS000080DF1E_32630 19228039 32630 gcgccagaacu ........... ........... Crystal structure of the product Bacillus anthracis glmS ribozyme; RNA (5'-R(*GP*CP*GP*CP*CP*AP*GP*AP*AP*CP*U)-3') 3g9c Q 141 2.9 RF00234 URS000080E011_32630 19228039 0003824 0010468 32630 ngcaccauugcacuccggugccaguugacgaggugggguuuaucgagauuucggcggaugacucccgguuguucaucacaaccgcaagcuuuuacuuaaaucauuaaggugacuuaguggacaaaggugaaagugugauga <<<<<<..........>>>>>>......(((...<<<<<<..)))..............>>>>>><<<<<<.(((((.>>>>>>...<<<<<<<<<....<<<<<<<<....>>>>>>>>.....>>>>>>>>>..))))) ((((((..........))))))......[[[...((((((..]]]..............))))))((((((.[[[[[[))))))...(((((((((.....(((((((....)))))))......))))))))).]]]]]] Crystal structure of the product Bacillus anthracis glmS ribozyme; GLMS RIBOZYME 3g9c G 11 2.9 URS000080DF1E_32630 19228039 32630 gcgccagaacu ........... ........... Crystal structure of the product Bacillus anthracis glmS ribozyme; RNA (5'-R(*GP*CP*GP*CP*CP*AP*GP*AP*AP*CP*U)-3') 3g9c R 141 2.9 RF00234 URS000080E011_32630 19228039 0003824 0010468 32630 ngcaccauugcacuccggugccaguugacgaggugggguuuaucgagauuucggcggaugacucccgguuguucaucacaaccgcaagcuuuuacuuaaaucauuaaggugacuuaguggacaaaggugaaagugugauga <<<<<<..........>>>>>>......(((...<<<<<<..)))..............>>>>>><<<<<<.(((((.>>>>>>...<<<<<.<<<....<<<<<<<<....>>>>>>>.>....>>>>.>>>>..))))) ((((((..........))))))......[[[...((((((..]]]..............))))))((((((.[[[[[[)))))).....(((...(.....(((((((....)))))))......)..)))....]]]]]] Crystal structure of the product Bacillus anthracis glmS ribozyme; GLMS RIBOZYME 3g9c H 11 2.9 URS000080DF1E_32630 19228039 32630 gcgccagaacu ........... ........... Crystal structure of the product Bacillus anthracis glmS ribozyme; RNA (5'-R(*GP*CP*GP*CP*CP*AP*GP*AP*AP*CP*U)-3') 3g9c S 140 2.9 RF00234 URS000080E011_32630 19228039 0003824 0010468 32630 ngcaccauugcacuccggugccaguugacgaggugggguuuaucgagauuucggcggaugacucccgguuguucaucacaaccgcaagcuuuuacuuaaaucauuaaggugacuuaguggacaaaggugaaagugugaug <<<<<<..........>>>>>>......(((...<<<<<<..)))..............>>>>>><<<<<<...((((>>>>>>...<<<<<<<<<....<<<<<<<<....>>>>>>>>.....>>>>>>>>>.)))). ((((((..........))))))......[[[...((((((..]]]..............))))))((((((...[[[[))))))...(((((((((.....(((((((....)))))))......))))))))).]]]]. Crystal structure of the product Bacillus anthracis glmS ribozyme; GLMS RIBOZYME 3gm7 G 18 1.58 URS000080DEA4_32630 19433512,16269545 32630 cugcugcugcugcugcug .................. .................. 1.58 A resolution X-ray structure of (CUG)6; 5'-R(*CP*UP*GP*CP*UP*GP*CP*UP*GP*CP*UP*GP*CP*UP*GP*CP*UP*G)-3' 3gm7 H 18 1.58 URS000080DEA4_32630 19433512,16269545 32630 cugcugcugcugcugcug .................. .................. 1.58 A resolution X-ray structure of (CUG)6; 5'-R(*CP*UP*GP*CP*UP*GP*CP*UP*GP*CP*UP*GP*CP*UP*GP*CP*UP*G)-3' 3gs1 A 13 2.85 URS000080E1AE_32630 19354216 32630 ucccaguccaccg ............. ............. An all-RNA Hairpin Ribozyme with mutation A38N1dA; RNA (5'-R(*UP*CP*CP*CP*AP*GP*UP*CP*CP*AP*CP*CP*GP*U)-3') 3gs1 B 12 2.85 URS000080DF3F_32630 19354216 32630 cggugagaaggg ............ ............ An all-RNA Hairpin Ribozyme with mutation A38N1dA; RNA (5'-R(*CP*GP*GP*UP*GP*AP*GP*AP*AP*GP*GP*G)-3') 3gs1 C 17 2.85 URS000080DEF8_32630 19354216 32630 ggcagagaaacacacga ................. ................. An all-RNA Hairpin Ribozyme with mutation A38N1dA; RNA (5'-R(P*GP*GP*CP*AP*GP*AP*GP*AP*AP*AP*CP*AP*CP*AP*CP*GP*A)-3') 3gs1 D 19 2.85 URS000080E34C_32630 19354216 32630 ucgugguacauuaccugcc ................... ................... An all-RNA Hairpin Ribozyme with mutation A38N1dA; RNA (5'-R(*UP*CP*GP*UP*GP*GP*UP*AP*CP*AP*UP*UP*AP*CP*CP*UP*GP*CP*C)-3') 3gs5 A 25 2.75 URS000080DEFD_32630 19354216 32630 ucccaguccaccgcggugagaaggg .<<<....<<<<..>>>>....>>> .(((....((((()))))....))) An all-RNA hairpin ribozyme A38N1dA variant with a product mimic substrate strand; RNA (25-MER) 3gs5 C 36 2.75 URS000080E033_32630 19354216 32630 ggcagagaaacacacgaucgugguacauuaccugcc <<<<<....<..<<<<..>>>>.....>...>>>>> (((((...(...((((()))))......)..))))) An all-RNA hairpin ribozyme A38N1dA variant with a product mimic substrate strand; RNA (36-MER) 3gs8 A 13 2.85 URS000080E1AE_32630 19354216 32630 ucccaguccaccg ............. ............. An all-RNA hairpin ribozyme A38N1dA38 variant with a transition-state mimic substrate strand; RNA (5'-R(*UP*CP*CP*CP*AP*GP*UP*CP*CP*AP*CP*CP*GP*U)-3') 3gs8 B 12 2.85 URS000080DF3F_32630 19354216 32630 cggugagaaggg ............ ............ An all-RNA hairpin ribozyme A38N1dA38 variant with a transition-state mimic substrate strand; RNA (5'-R(*CP*GP*GP*UP*GP*AP*GP*AP*AP*GP*GP*G)-3') 3gs8 C 17 2.85 URS000080DEF8_32630 19354216 32630 ggcagagaaacacacga ................. ................. An all-RNA hairpin ribozyme A38N1dA38 variant with a transition-state mimic substrate strand; RNA (5'-R(P*GP*GP*CP*AP*GP*AP*GP*AP*AP*AP*CP*AP*CP*AP*CP*GP*A)-3') 3gs8 D 19 2.85 URS000080E34C_32630 19354216 32630 ucgugguacauuaccugcc ................... ................... An all-RNA hairpin ribozyme A38N1dA38 variant with a transition-state mimic substrate strand; RNA (5'-R(*UP*CP*GP*UP*GP*GP*UP*AP*CP*AP*UP*UP*AP*CP*CP*UP*GP*CP*C)-3') 3hax E 60 2.11 URS000080DEF7_32630 19481523 32630 ggguccgccuugagugcccgggugagagcaugaucccggguaauuauggcggacccacag <<<<<<<<<......<<<<<<<............>>>>>>>......>>>>>>>>>.... (((((((((......(((((((............)))))))......))))))))).... Crystal structure of a substrate-bound Gar1-minus H/ACA RNP from Pyrococcus furiosus; H/ACA RNA 3hax F 14 2.11 URS000080E10E_32630 19481523 32630 auaauungacucaa .............. .............. Crystal structure of a substrate-bound Gar1-minus H/ACA RNP from Pyrococcus furiosus; 5'-R(*AP*UP*AP*AP*UP*UP*(FHU)P*GP*AP*CP*UP*CP*AP*A)-3' 3hay E 69 4.99 URS000080E0C4_32630 19481523 32630 ggcugccuggguccgccuugagugcccgggugagaagcaugaucccggguaauuauggcggacccacag ........<<<<<<<<<......<<<<<<<.............>>>>>>>......>>>>>>>>>.... ........(((((((((......(((((((.............)))))))......))))))))).... Crystal structure of a substrate-bound full H/ACA RNP from Pyrococcus furiosus; H/ACA RNA 3hay F 14 4.99 URS000080E10E_32630 19481523 32630 auaauungacucaa .............. .............. Crystal structure of a substrate-bound full H/ACA RNP from Pyrococcus furiosus; 5'-R(*AP*UP*AP*AP*UP*UP*(FHU)P*GP*AP*CP*UP*CP*AP*A)-3' 3hhz R 45 3.5 URS000080E17E_562 19571006 562 uuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuu ............................................. ............................................. Complex of the vesicular stomatitis virus nucleocapsid and the nucleocapsid-binding domain of the phosphoprotein; RNA (45-MER) 3hjw D 58 2.35 RF02796 URS000080DEB8_32630 19478803 0006396 32630 gggccacggaaaccgcgcgcggugaucaaugagccgcguucgcucccguggcccacaa <<<<<<<<<.......<<<<<<<.........>>>>>>>......>>>>>>>>>.... (((((((((.......(((((((.........)))))))......))))))))).... Structure of a functional ribonucleoprotein pseudouridine synthase bound to a substrate RNA; RNA (58-MER) 3hjw E 13 2.35 URS000080DF79_32630 19478803 32630 gagcgngcgguuu ............. ............. Structure of a functional ribonucleoprotein pseudouridine synthase bound to a substrate RNA; 5'-R(*GP*AP*GP*CP*GP*(FHU)P*GP*CP*GP*GP*UP*UP*U)-3' 3hjy C 21 3.65 URS000080E178_32630 19478803 32630 gggcuccggaaaccgcggcgc ..................... ..................... Structure of a functional ribonucleoprotein pseudouridine synthase bound to a substrate RNA; 5'-R(*GP*GP*GP*CP*UP*CP*CP*GP*GP*AP*AP*AP*CP*CP*GP*CP*GP*GP*CP*GP*C)-3' 3hjy D 25 3.65 URS000080E1A8_32630 19478803 32630 gcgcuucgcucccggagcccacacu ......................... ......................... Structure of a functional ribonucleoprotein pseudouridine synthase bound to a substrate RNA; RNA (25-MER) 3hjy E 14 3.65 URS000080E065_32630 19478803 32630 ggagcgugcgguuu .............. .............. Structure of a functional ribonucleoprotein pseudouridine synthase bound to a substrate RNA; 5'-R(*GP*GP*AP*GP*CP*GP*UP*GP*CP*GP*GP*UP*UP*U)-3' 3htx B 22 3.1 URS000080E2CB_32630 19812675 32630 gauuucucucugcaagcgaaag ...................... ...................... Crystal structure of small RNA methyltransferase HEN1; 5'-R(*GP*AP*UP*UP*UP*CP*UP*CP*UP*CP*UP*GP*CP*AP*AP*GP*CP*GP*AP*AP*AP*G)-3' 3htx C 22 3.1 URS00005F3E4D_32630 19812675 32630 uucgcuugcagagagaaaucac ...................... ...................... Crystal structure of small RNA methyltransferase HEN1; 5'-R(P*UP*UP*CP*GP*CP*UP*UP*GP*CP*AP*GP*AP*GP*AP*GP*AP*AP*AP*UP*CP*AP*C)-3' 3htx E 22 3.1 URS000080E2CB_32630 19812675 32630 gauuucucucugcaagcgaaag ...................... ...................... Crystal structure of small RNA methyltransferase HEN1; 5'-R(*GP*AP*UP*UP*UP*CP*UP*CP*UP*CP*UP*GP*CP*AP*AP*GP*CP*GP*AP*AP*AP*G)-3' 3htx F 22 3.1 URS00005F3E4D_32630 19812675 32630 uucgcuugcagagagaaaucac ...................... ...................... Crystal structure of small RNA methyltransferase HEN1; 5'-R(P*UP*UP*CP*GP*CP*UP*UP*GP*CP*AP*GP*AP*GP*AP*GP*AP*AP*AP*UP*CP*AP*C)-3' 3i2q A 13 2.9 URS000080E1AE_32630 19634899 32630 ucccnguccaccg ............. ............. Crystal structure of the hairpin ribozyme with 2'OMe substrate strand and N1-deazaadenosine at position A9; 5'-R(*UP*CP*CP*CP*(A2M)P*GP*UP*CP*CP*AP*CP*CP*GP*U)-3' 3i2q B 30 2.9 URS000080DE46_32630 19634899 32630 cggugagnagggnggcagagaaacacacga .............................. .............................. Crystal structure of the hairpin ribozyme with 2'OMe substrate strand and N1-deazaadenosine at position A9; DNA/RNA (30-MER) 3i2q C 19 2.9 URS000080E34C_32630 19634899 32630 ucgugguacauuaccugcc ................... ................... Crystal structure of the hairpin ribozyme with 2'OMe substrate strand and N1-deazaadenosine at position A9; 5'-R(*UP*CP*GP*UP*GP*GP*UP*AP*CP*AP*UP*UP*AP*CP*CP*UP*GP*CP*C)-3' 3i2r A 13 2.8 URS000080E1AE_32630 19634899 32630 ucccaguccaccg ............. ............. Crystal structure of the hairpin ribozyme with a 2',5'-linked substrate with N1-deazaadenosine at position A9; 5'-R(*UP*CP*CP*CP*AP*GP*UP*CP*CP*AP*CP*CP*GP*U)-3' 3i2r B 30 2.8 URS000080DE46_32630 19634899 32630 cggugagnagggnggcagagaaacacacga .............................. .............................. Crystal structure of the hairpin ribozyme with a 2',5'-linked substrate with N1-deazaadenosine at position A9; DNA/RNA (30-MER) 3i2r C 19 2.8 URS000080E34C_32630 19634899 32630 ucgugguacauuaccugcc ................... ................... Crystal structure of the hairpin ribozyme with a 2',5'-linked substrate with N1-deazaadenosine at position A9; 5'-R(*UP*CP*GP*UP*GP*GP*UP*AP*CP*AP*UP*UP*AP*CP*CP*UP*GP*CP*C)-3' 3i2s A 13 2.75 URS000080E1AE_32630 19634899 32630 ucccnguccaccg ............. ............. Crystal structure of the hairpin ribozyme with a 2'OMe substrate and N1-deazaadenosine at position A10; 5'-R(*UP*CP*CP*CP*(A2M)P*GP*UP*CP*CP*AP*CP*CP*GP*U)-3' 3i2s B 30 2.75 URS000080E18D_32630 19634899 32630 cggugagangggnggcagagaaacacacga .............................. .............................. Crystal structure of the hairpin ribozyme with a 2'OMe substrate and N1-deazaadenosine at position A10; DNA/RNA (30-MER) 3i2s C 19 2.75 URS000080E34C_32630 19634899 32630 ucgugguacauuaccugcc ................... ................... Crystal structure of the hairpin ribozyme with a 2'OMe substrate and N1-deazaadenosine at position A10; 5'-R(*UP*CP*GP*UP*GP*GP*UP*AP*CP*AP*UP*UP*AP*CP*CP*UP*GP*CP*C)-3' 3i2u A 13 2.8 URS000080E1AE_32630 19634899 32630 ucccaguccaccg ............. ............. Crystal structure of the haiprin ribozyme with a 2',5'-linked substrate and N1-deazaadenosine at position A10; 5'-R(*UP*CP*CP*CP*AP*GP*UP*CP*CP*AP*CP*CP*GP*U)-3' 3i2u B 30 2.8 URS000080E18D_32630 19634899 32630 cggugagangggnggcagagaaacacacga .............................. .............................. Crystal structure of the haiprin ribozyme with a 2',5'-linked substrate and N1-deazaadenosine at position A10; DNA/RNA (30-MER) 3i2u C 19 2.8 URS000080E34C_32630 19634899 32630 ucgugguacauuaccugcc ................... ................... Crystal structure of the haiprin ribozyme with a 2',5'-linked substrate and N1-deazaadenosine at position A10; 5'-R(*UP*CP*GP*UP*GP*GP*UP*AP*CP*AP*UP*UP*AP*CP*CP*UP*GP*CP*C)-3' 3i55 0 2754 3.11 RF02540,RF00002 URS000080E102_272569 19738021 0003735 0005840 272569 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagcuguggggagccgcacggaggcgaagaaccacagauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaacgugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucuucacgaagucucuuggaauagagcgugauacagggugacaaccccguacugaagaccaguacgcugugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccuugacgaaugaccgagacgcgagucuccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucuguauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgcuguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaagcaggggcgagagcuccuguggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucucaccgcaacucgacugagacgaaaugggaaacagguuaauauuccugugccaucaugcagugaaaguugacgcccuggggucgaucacgccgggcaucgcccggucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcaugauguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcgaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggucaucucagccggggacccggcgaagagugcaagagcaaaagaugacuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcugggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<.....>>..<<<<<<.....<<.....>>....>>>>>>..<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<<<<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>>>>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<.<<<.........<<<<<....>>>>>.........>>>.>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<.<<<.....>>>.>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<<...<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>>....<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>...........>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>.>>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......((((.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......))))...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((.(((....(....(((((....))))).....)...))).))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....)).....((((...((((..))))...)))).((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((...{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))(.....)........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).)........((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).).....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}...)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Co-crystal structure of Mycalamide A Bound to the Large Ribosomal Subunit; 23S ribosomal RNA 3i55 9 122 3.11 RF00001 URS00000A7E81_2238 19738021 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccagggaguacuggagugcgcgagccucugggaaauccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<.<<.....<<<<<<.<<....>>>>>>>>....>>.>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...((.(......((((((.((....)))))))).....).))...))))))... Co-crystal structure of Mycalamide A Bound to the Large Ribosomal Subunit; 5S ribosomal RNA 3i56 0 2754 2.9 RF02540,RF00002 URS000080DF02_272569 19738021 0003735 0005840 272569 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagcuguggggagccgcacggaggcgaagaaccacagauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaacgugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucuucacgaagucucuuggaauagagcgugauacagggugacaaccccguacugaagaccaguacgcugugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccuugacgaaugaccgagacgcgagucuccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucuguauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgcuguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaagcaggggcgagagcuccuguggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucucaccgcaacucgacugagacgaaaugggaaacagguuaauauuccugugccaucaugcagugaaaguugacgcccuggggucgaucacgccgggcaucgcccggucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcaugauguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcaaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggucaucucagccggggacccggcgaagagugcaagagcaaaagaugacuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcugggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa ..<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>...<<<<<.....<<.....>>....>>>>>...<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<<<<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>>>>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<.<<<.........<<<<<....>>>>>.........>>>.>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<..>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<.>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<<<<<.....>>>>>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<<...<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.[[>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>.>>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<...>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<....>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<]]..>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>.....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>.. ...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......((((.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......))))...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......((..(((.....))).)...........)).....)))))))))......(.((((((((((....((((((.(((....(....(((((....))))).....)...))).))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.(((....(((((((....)))))))....[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((.))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..)))........(((......)))..)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Co-crystal structure of Triacetyloleandomcyin Bound to the Large Ribosomal Subunit; 23S ribosomal RNA 3i56 9 122 2.9 RF00001 URS00000A7E81_2238 19738021 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccagggaguacuggagugcgcgagccucugggaaauccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<.<<.....<<<<<<.<<....>>>>>>>>....>>.>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...((.(......((((((.((....)))))))).....).))...))))))... Co-crystal structure of Triacetyloleandomcyin Bound to the Large Ribosomal Subunit; 5S ribosomal RNA 3ibk A 12 2.2 URS000080E0FC_32630 20413582 32630 naggguuagggu ............ ............ Crystal structure of a telomeric RNA quadruplex; RNA (5'-R(*(5BU)P*AP*GP*GP*GP*UP*UP*AP*GP*GP*GP*U)-3') 3ibk B 12 2.2 URS000080E0FC_32630 20413582 32630 naggguuagggu ............ ............ Crystal structure of a telomeric RNA quadruplex; RNA (5'-R(*(5BU)P*AP*GP*GP*GP*UP*UP*AP*GP*GP*GP*U)-3') 3igi A 389 3.125 RF02001,RF01998 URS000080DD31_182710 19952115 0000373 182710 ugugcccggcaugggugcagucuauagggugagagucccgaacugugaaggcagaaguaacaguuagccuaacgcaaggguguccguggcgacauggaaucugaaggaagcggacggcaaaccuucggucugaggaacacgaacuucauaugaggcuagguaucaauggaugaguuugcauaacaaaacaaaguccuuucugccaaaguugguacagaguaaaugaagcagauugaugaagggaaagacugcauucuuacccggggaggucuggaaacagaagucagcagaagucauaguacccuguucgcaggggaaggacggaacaaguauggcguucgcgccuaagcuugaaccgccguauaccgaacgguacguacgguggugug ....<<<<<...<<<<<<<<<<<...<<<.......>>>..(((((...<<<<<<<...)))))..<<<...<<<..<<<<.<<<<<<....>>>>>>>>>>.......>>>...>>>...(((((([[[[[...........[[[[[......[[[....((((((<<<<..<<<<........>>>>...>>>>.>>>>>>>...))))))....]]]...]]]]]]]]]]...))))))...>>>>>>>>>>>....>>>>>....<<<<....>>>>...........<<<......<<<<......>>>>....>>>....<<<<<..<<<<....>>>>...>>>>>.<<<<<<<<<<<<<....>>>..>>>>>>>>>>... .[<.((((({..(((((((((((...(((.......)))..(((((...[[[[[[[...)))))..(((...(((..((((.((((((....))))))))))...>}..)))...)))...(((((((((((.(.....)...(((((.....[(((....(.((((((((..((((.]......))))...)))).]]]]]]]...)))).)....)))...))))))))))...))))))...)))))))))))...])))))(...((((....))))...).......(((.(....(((........)))...))))....(((((.(((((....))))..)))))).(((((((((((((....)))..))))))))))... Tertiary Architecture of the Oceanobacillus Iheyensis Group II Intron; Group IIC intron 3iin B 197 4.18 RF00028 URS000080E37C_32630 20145044 0000372 32630 ngccgugugccuugcgccgggaaaccacgcaagggauggugucaaauucggcgaaaccuaagcgcccgcccgggcguauggcaacgccgagccaagcuucgcagccauugcacuccggcugcgaugaagguguagagacuagacggcacccaccuaaggcaaacgcuauggugaaggcauaguccagggaguggcgn .........<<<<<<<..<<....>>.>>>>>>>...<<<<<<....<<<<<<...<<...<<<<<......>>>>>..>>...>>>>>><<<.....<<<<<<<<..........>>>>>>>>....>>>.....(((((...>>>>>><<<<...<<<....>>>..>>>>......)))))............. .........(((((((..((....)).)))))))...((((((....((((((...((...((((((....))))))..))...))))))(((...(.((((.(((..........))).)))).)..)))...[.[[[[[...))))))((((...(((....)))..))))......]]]]]]............ Plasticity of the kink turn structural motif; Group I intron 3iin C 22 4.18 URS000080DE17_32630 20145044 32630 aagccacacagaccagacggcc ...................... ...................... Plasticity of the kink turn structural motif; DNA/RNA (5'-R(*AP*AP*GP*CP*CP*AP*CP*AP*CP*AP*GP*AP*CP*C)-D(P*AP*GP*A)-R(P*CP*GP*GP*CP*C)-3') 3izz E 100 10.8 RF00177 URS000080E00A_562 21368145 0003735 0005840 562 caccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaac ....<..<<.<.<<<<.<<<..<<<<..<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>..>>>>..>>>.>>>>..>.>>...> ....(..((.(.((((.(((..((((...((((((...(.((((....(((....))).)))).)..))))))...))))..))).))))..).))...) Models for ribosome components that are nearest neighbors to the bovine mitochondrial initiation factor2 bound to the E. Coli ribosome; Helix 44 (Small Subunit) 3izz B 118 10.8 RF02541 URS000080DD41_562 21368145 0003735 0005840 562 ggccguaacuauaacggucucggguaaguuccgacugauaccgcccaagaguucauaucgacggcgguguuuggauggcuguucgccaucugcuccuaguacgagaggaccggagugg .<<<<<.......>>>>>.<<<<.......>>>><<...<<<<<<...<<.......>>...>>>>>>....>><<<<<.....>>>>><<<<<<<...............>>>>>>> (((((.........)))))((((.......))))((.(.((((((...((.......))...))))))...)))(((((.....)))))(((((((.....(....)....))))))) Models for ribosome components that are nearest neighbors to the bovine mitochondrial initiation factor2 bound to the E. Coli ribosome; Helix 69, 71, 89, 92, 95 (Large Subunit) 3j0d B 22 11.1 URS000080E08E_562 22388519 562 cggccguaacuauaacgguccu .<<<<<<.......>>>>>>.. .(((((.........))))).. Models for the T. thermophilus ribosome recycling factor bound to the E. coli post-termination complex; ribosomal 23S RNA 3j0d C 17 11.1 URS000080E142_562 22388519 562 gucggguaaguuccgac <<<<<.......>>>>> (((((.......))))) Models for the T. thermophilus ribosome recycling factor bound to the E. coli post-termination complex; ribosomal 23S RNA 3j0d H 18 11.1 URS000080E01A_562 22388519 562 cgucacaccaugggagug .................. .................. Models for the T. thermophilus ribosome recycling factor bound to the E. coli post-termination complex; ribosomal 16S RNA 3j0d h 19 11.1 URS000080DD70_562 22388519 562 caugacuggggugaagucg ................... ................... Models for the T. thermophilus ribosome recycling factor bound to the E. coli post-termination complex; ribosomal 16S RNA 3j0e A 22 9.9 URS000080E08E_562 22388519 562 cggccguaacuauaacgguccu .<<<<<<.......>>>>>>.. .(((((.........))))).. Models for the T. thermophilus ribosome recycling factor and the E. coli elongation factor G bound to the E. coli post-termination complex; ribosomal 23S RNA 3j0e B 17 9.9 URS000080E142_562 22388519 562 gucggguaaguuccgac <<<<<.......>>>>> (((((.......))))) Models for the T. thermophilus ribosome recycling factor and the E. coli elongation factor G bound to the E. coli post-termination complex; ribosomal 23S RNA 3j0e E 18 9.9 URS000080E01A_562 22388519 562 cgucacaccaugggagug .................. .................. Models for the T. thermophilus ribosome recycling factor and the E. coli elongation factor G bound to the E. coli post-termination complex; ribosomal 16S RNA 3j0e e 19 9.9 URS000080DD70_562 22388519 562 caugacuggggugaagucg ................... ................... Models for the T. thermophilus ribosome recycling factor and the E. coli elongation factor G bound to the E. coli post-termination complex; ribosomal 16S RNA 3j0l b 12 9.8 URS000080E1AB_9986 22017870 9986 gaggugaaauuc <<<......>>> ((........)) Core of mammalian 80S pre-ribosome in complex with tRNAs fitted to a 9.8A cryo-EM map: classic PRE state 1; 40S ribosomal RNA fragment 3j0l c 17 9.8 URS000080E311_9986 22017870 9986 gacgaucagauaccguc <<<<.........>>>> ((((.........)))) Core of mammalian 80S pre-ribosome in complex with tRNAs fitted to a 9.8A cryo-EM map: classic PRE state 1; 40S ribosomal RNA fragment 3j0l g 31 9.8 URS000080E146_9986 22017870 9986 gaaccugcggcuuaauuugacucaacacggg .................<<........>>.. ..................(........)... Core of mammalian 80S pre-ribosome in complex with tRNAs fitted to a 9.8A cryo-EM map: classic PRE state 1; 40S ribosomal RNA fragment 3j0l G 13 9.8 URS000080E14F_9986 22017870 9986 gcacgcgcguuac ............. ............. Core of mammalian 80S pre-ribosome in complex with tRNAs fitted to a 9.8A cryo-EM map: classic PRE state 1; 40S ribosomal RNA fragment 3j0l h 111 9.8 RF01960 URS000080E29C_9986 22017870 0003735 0005840 9986 caccgcccgucgcuuguaguaacgaauggucuggugaaccuucuggacugcgacagcaauguugcggaaaaauaaguaaacccuaccauuuggaacaacaagaagucguaa .......<<.<.<<<<<.....<<<<<<<<..<<<..<<.<..<...<<<<<<<<....>>>>>>>>...>..>.>>..>>>..>>>>>>>>.....>>>>>..>.>>... .......((.(.(((((.....(.((((((..(((..((.(..(...(.((.(((....))).)).)...)..).))..)))..)))))).).....)))))..).))... Core of mammalian 80S pre-ribosome in complex with tRNAs fitted to a 9.8A cryo-EM map: classic PRE state 1; 40S ribosomal RNA fragment 3j0l 2 112 9.8 RF02543,RF02540 URS000080E198_9986 22017870 0003735 0005840 9986 gcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacg <<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>>.<<<<<.......>>>>>.....................<<<<<.......>>>>>. (((..((((((.(...((.....((((....)))).....)).)))))..))))).((((.........))).)....................(((((.......))))). Core of mammalian 80S pre-ribosome in complex with tRNAs fitted to a 9.8A cryo-EM map: classic PRE state 1; 60S ribosomal RNA fragment 3j0l 3 12 9.8 URS000080DDAF_9986 22017870 9986 gccagugaaaua ............ ............ Core of mammalian 80S pre-ribosome in complex with tRNAs fitted to a 9.8A cryo-EM map: classic PRE state 1; 60S ribosomal RNA fragment 3j0l 4 14 9.8 URS000080DD58_9986 22017870 9986 ggcuggggcggcac .<<<.....>>>.. (((.......)).) Core of mammalian 80S pre-ribosome in complex with tRNAs fitted to a 9.8A cryo-EM map: classic PRE state 1; 60S ribosomal RNA fragment 3j0l 7 50 9.8 RF02543 URS000080E22D_9986 22017870 0003735 0005840 9986 gcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgau <.<...<<<<<<...<<.......>>...>>>>>>....>.>........ (.(.(.((((.(...((.......))...).))))...)).)........ Core of mammalian 80S pre-ribosome in complex with tRNAs fitted to a 9.8A cryo-EM map: classic PRE state 1; 60S ribosomal RNA fragment 3j0l 8 20 9.8 URS0000791C4B_9986 22017870 9986 gaccgucgugagacagguua <<<<<<<....>>>.>>>>. (((((((....))).)))). Core of mammalian 80S pre-ribosome in complex with tRNAs fitted to a 9.8A cryo-EM map: classic PRE state 1; 60S ribosomal RNA fragment 3j0l Y 75 9.8 RF00005 URS00005AA258_9986 22017870 0030533 0006412 9986 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacc <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>... (..((((..((............))..((((.......))))......((.((.......)).))))))..)... Core of mammalian 80S pre-ribosome in complex with tRNAs fitted to a 9.8A cryo-EM map: classic PRE state 1; tRNA 3j0l V 75 9.8 RF00005 URS00005AA258_9986 22017870 0030533 0006412 9986 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacc <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>... (((((((..((((.....[..)))).(((((.......))))).....(((((..]....))))))))))))... Core of mammalian 80S pre-ribosome in complex with tRNAs fitted to a 9.8A cryo-EM map: classic PRE state 1; tRNA 3j0l W 76 9.8 RF00005 URS00005AA258_9986 22017870 0030533 0006412 9986 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((........)))).((((.........)))).....((.((.......)).))))))))).... Core of mammalian 80S pre-ribosome in complex with tRNAs fitted to a 9.8A cryo-EM map: classic PRE state 1; tRNA 3j0o b 12 9.0 URS000080E1AB_9986 22017870 9986 gaggugaaauuc <<<......>>> ((........)) Core of mammalian 80S pre-ribosome in complex with tRNAs fitted to a 9A cryo-EM map: classic PRE state 2; 40S ribosomal RNA fragment 3j0o c 17 9.0 URS000080E311_9986 22017870 9986 gacgaucagauaccguc <<<<.........>>>> ((((.........)))) Core of mammalian 80S pre-ribosome in complex with tRNAs fitted to a 9A cryo-EM map: classic PRE state 2; 40S ribosomal RNA fragment 3j0o g 31 9.0 URS000080E146_9986 22017870 9986 gaaccugcggcuuaauuugacucaacacggg .................<<........>>.. ..................(........)... Core of mammalian 80S pre-ribosome in complex with tRNAs fitted to a 9A cryo-EM map: classic PRE state 2; 40S ribosomal RNA fragment 3j0o G 13 9.0 URS000080E14F_9986 22017870 9986 gcacgcgcguuac ............. ............. Core of mammalian 80S pre-ribosome in complex with tRNAs fitted to a 9A cryo-EM map: classic PRE state 2; 40S ribosomal RNA fragment 3j0o h 111 9.0 RF01960 URS000080E29C_9986 22017870 0003735 0005840 9986 caccgcccgucgcuuguaguaacgaauggucuggugaaccuucuggacugcgacagcaauguugcggaaaaauaaguaaacccuaccauuuggaacaacaagaagucguaa .......<<.<.<<<<<.....<<<<<<<<..<<<..<<.<..<...<<<<<<<<....>>>>>>>>...>..>.>>..>>>..>>>>>>>>.....>>>>>..>.>>... .......((.(.(((((.....(.((((((..(((..((.(..(...(.((.(((....))).)).)...)..).))..)))..)))))).).....)))))..).))... Core of mammalian 80S pre-ribosome in complex with tRNAs fitted to a 9A cryo-EM map: classic PRE state 2; 40S ribosomal RNA fragment 3j0o 2 112 9.0 RF02543,RF02540 URS000080E198_9986 22017870 0003735 0005840 9986 gcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacg <<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>>.<<<<<.......>>>>>.....................<<<<<.......>>>>>. (((..((((((.(...((.....((((....)))).....)).)))))..))))).((((.........))).)....................(((((.......))))). Core of mammalian 80S pre-ribosome in complex with tRNAs fitted to a 9A cryo-EM map: classic PRE state 2; 60S ribosomal RNA fragment 3j0o 3 12 9.0 URS000080DDAF_9986 22017870 9986 gccagugaaaua ............ ............ Core of mammalian 80S pre-ribosome in complex with tRNAs fitted to a 9A cryo-EM map: classic PRE state 2; 60S ribosomal RNA fragment 3j0o 4 14 9.0 URS000080DD58_9986 22017870 9986 ggcuggggcggcac .<<<.....>>>.. (((.......)).) Core of mammalian 80S pre-ribosome in complex with tRNAs fitted to a 9A cryo-EM map: classic PRE state 2; 60S ribosomal RNA fragment 3j0o 6 19 9.0 URS000080E220_9986 22017870 9986 agaacaaaaggguaaaagc ...<<......>>...... ...((......))...... Core of mammalian 80S pre-ribosome in complex with tRNAs fitted to a 9A cryo-EM map: classic PRE state 2; 60S ribosomal RNA fragment 3j0o 7 50 9.0 RF02543 URS000080E22D_9986 22017870 0003735 0005840 9986 gcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgau <.<...<<<<<<...<<.......>>...>>>>>>....>.>........ (.(.(.((((.(...((.......))...).))))...)).)........ Core of mammalian 80S pre-ribosome in complex with tRNAs fitted to a 9A cryo-EM map: classic PRE state 2; 60S ribosomal RNA fragment 3j0o 8 20 9.0 URS0000791C4B_9986 22017870 9986 gaccgucgugagacagguua <<<<<<<....>>>.>>>>. (((((((....))).)))). Core of mammalian 80S pre-ribosome in complex with tRNAs fitted to a 9A cryo-EM map: classic PRE state 2; 60S ribosomal RNA fragment 3j0o Y 75 9.0 RF00005 URS00005AA258_9986 22017870 0030533 0006412 9986 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacc <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>... (..((((..((............))..((((.......))))......((.((.......)).))))))..)... Core of mammalian 80S pre-ribosome in complex with tRNAs fitted to a 9A cryo-EM map: classic PRE state 2; tRNA 3j0o V 75 9.0 RF00005 URS00005AA258_9986 22017870 0030533 0006412 9986 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacc <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>... (((((((..((((.....[..)))).(((((.......))))).....(((((..]....))))))))))))... Core of mammalian 80S pre-ribosome in complex with tRNAs fitted to a 9A cryo-EM map: classic PRE state 2; tRNA 3j0o W 76 9.0 RF00005 URS00005AA258_9986 22017870 0030533 0006412 9986 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((........)))).((((.........)))).....((.((.......)).))))))))).... Core of mammalian 80S pre-ribosome in complex with tRNAs fitted to a 9A cryo-EM map: classic PRE state 2; tRNA 3j0p c 17 10.6 URS000080E311_9986 22017870 9986 gacgaucagauaccguc <<<<.........>>>> ((((.........)))) Core of mammalian 80S pre-ribosome in complex with tRNAs fitted to a 10.6A cryo-em map: rotated PRE state 1; 40S ribosomal RNA fragment 3j0p g 31 10.6 URS000080E146_9986 22017870 9986 gaaccugcggcuuaauuugacucaacacggg .................<<........>>.. ..................(........)... Core of mammalian 80S pre-ribosome in complex with tRNAs fitted to a 10.6A cryo-em map: rotated PRE state 1; 40S ribosomal RNA fragment 3j0p G 13 10.6 URS000080E14F_9986 22017870 9986 gcacgcgcguuac ............. ............. Core of mammalian 80S pre-ribosome in complex with tRNAs fitted to a 10.6A cryo-em map: rotated PRE state 1; 40S ribosomal RNA fragment 3j0p h 111 10.6 RF01960 URS000080E29C_9986 22017870 0003735 0005840 9986 caccgcccgucgcuuguaguaacgaauggucuggugaaccuucuggacugcgacagcaauguugcggaaaaauaaguaaacccuaccauuuggaacaacaagaagucguaa .......<<.<.<<<<<.....<<<<<<<<..<<<..<<.<..<...<<<<<<<<....>>>>>>>>...>..>.>>..>>>..>>>>>>>>.....>>>>>..>.>>... .......((.(.(((((.....(.((((((..(((..((.(..(...(.((.(((....))).)).)...)..).))..)))..)))))).).....)))))..).))... Core of mammalian 80S pre-ribosome in complex with tRNAs fitted to a 10.6A cryo-em map: rotated PRE state 1; 40S ribosomal RNA fragment 3j0p 2 112 10.6 RF02543,RF02540 URS000080E198_9986 22017870 0003735 0005840 9986 gcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacg <<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>>.<<<<<.......>>>>>.....................<<<<<.......>>>>>. (((..((((((.(...((.....((((....)))).....)).)))))..))))).((((.........))).)....................(((((.......))))). Core of mammalian 80S pre-ribosome in complex with tRNAs fitted to a 10.6A cryo-em map: rotated PRE state 1; 60S ribosomal RNA fragment 3j0p 3 12 10.6 URS000080DDAF_9986 22017870 9986 gccagugaaaua ............ ............ Core of mammalian 80S pre-ribosome in complex with tRNAs fitted to a 10.6A cryo-em map: rotated PRE state 1; 60S ribosomal RNA fragment 3j0p Y 75 10.6 RF00005 URS000031D44F_9986 22017870 0030533 0006412 9986 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacc <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>... (..((((..((............))..((((.......))))......((.((.......)).))))))..)... Core of mammalian 80S pre-ribosome in complex with tRNAs fitted to a 10.6A cryo-em map: rotated PRE state 1; tRNA 3j0p W 77 10.6 RF00005 URS000041AF00_9986 22017870 0030533 0006412 9986 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Core of mammalian 80S pre-ribosome in complex with tRNAs fitted to a 10.6A cryo-em map: rotated PRE state 1; tRNA 3j0q g 31 10.6 URS000080E146_9986 22017870 9986 gaaccugcggcuuaauuugacucaacacggg .................<<........>>.. ..................(........)... Core of mammalian 80S pre-ribosome in complex with tRNAs fitted to a 10.6A cryo-em map: rotated PRE state 2; 40S ribosomal RNA fragment 3j0q G 13 10.6 URS000080E14F_9986 22017870 9986 gcacgcgcguuac ............. ............. Core of mammalian 80S pre-ribosome in complex with tRNAs fitted to a 10.6A cryo-em map: rotated PRE state 2; 40S ribosomal RNA fragment 3j0q h 111 10.6 RF01960 URS000080E29C_9986 22017870 0003735 0005840 9986 caccgcccgucgcuuguaguaacgaauggucuggugaaccuucuggacugcgacagcaauguugcggaaaaauaaguaaacccuaccauuuggaacaacaagaagucguaa .......<<.<.<<<<<.....<<<<<<<<..<<<..<<.<..<...<<<<<<<<....>>>>>>>>...>..>.>>..>>>..>>>>>>>>.....>>>>>..>.>>... .......((.(.(((((.....(.((((((..(((..((.(..(...(.((.(((....))).)).)...)..).))..)))..)))))).).....)))))..).))... Core of mammalian 80S pre-ribosome in complex with tRNAs fitted to a 10.6A cryo-em map: rotated PRE state 2; 40S ribosomal RNA fragment 3j0q 2 112 10.6 RF02543,RF02540 URS000080E198_9986 22017870 0003735 0005840 9986 gcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacg <<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>>.<<<<<.......>>>>>.....................<<<<<.......>>>>>. (((..((((((.(...((.....((((....)))).....)).)))))..))))).((((.........))).)....................(((((.......))))). Core of mammalian 80S pre-ribosome in complex with tRNAs fitted to a 10.6A cryo-em map: rotated PRE state 2; 60S ribosomal RNA fragment 3j0q 3 12 10.6 URS000080DDAF_9986 22017870 9986 gccagugaaaua ............ ............ Core of mammalian 80S pre-ribosome in complex with tRNAs fitted to a 10.6A cryo-em map: rotated PRE state 2; 60S ribosomal RNA fragment 3j0q 7 50 10.6 RF02543 URS000080E22D_9986 22017870 0003735 0005840 9986 gcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgau <.<...<<<<<<...<<.......>>...>>>>>>....>.>........ (.(.(.((((.(...((.......))...).))))...)).)........ Core of mammalian 80S pre-ribosome in complex with tRNAs fitted to a 10.6A cryo-em map: rotated PRE state 2; 60S ribosomal RNA fragment 3j0q Y 77 10.6 RF00005 URS000041AF00_9986 22017870 0030533 0006412 9986 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Core of mammalian 80S pre-ribosome in complex with tRNAs fitted to a 10.6A cryo-em map: rotated PRE state 2; tRNA 3j0q W 77 10.6 RF00005 URS000041AF00_9986 22017870 0030533 0006412 9986 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Core of mammalian 80S pre-ribosome in complex with tRNAs fitted to a 10.6A cryo-em map: rotated PRE state 2; tRNA 3j16 J 233 7.2 RF01960 URS000080DD66_4932 22358840 0003735 0005840 4932 cucaaagauuaagccaugugguaauucuaauccaaggaaagcaggcgcgcaaauuacccaauccuaauucagggagguagugaggagggcaagucuggugccagcagccgcgguaauuccagcuccugcggcuuaauuugacucaacacggggaaacucaccugguggugcauggcaggucugugaugcccuuacacaccgcccgucgcuaguacuaaaagucguaacaaggu .....<......<<<.<<.<<.....>>..<<....>>...>>>>>.........<<<....<<<.....>>>..>>>..>..<<<((......<<<<.....<<..))>>.......>>>>.>>>............<<........>>.............<<.<<<..<<.<....>.....>>>>>>>...........<<.<..<<<..>>>...>.>>......... .....((..[..(((.(((((.....))).((....))...))))).)...].(.(((...((((.....))).))))).)..((([[......((((.....((..]])).......)))).)))............((........)).............((.(((..((.((..)).....)))))))...........(..(..(((..)))...)..)......... Models of ribosome-bound Dom34p and Rli1p and their ribosomal binding partners; 28S ribosomal RNA 3j16 K 155 7.2 RF02543 URS000080E2D2_4932 22358840 0003735 0005840 4932 ccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggcggaguaacuaugacucucgccucgucaucuaauuaagucaagcguucauagcgacauugauuguucacccacugaacuuaguacgagaggaacaguuc <<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>..<<<<.......>>>>....................<<...<<.......>>...>>.<.........>....<<<<<...............>>>>> ((((.(((...((.........))...))).....(...((......)).).))))..(((.........)))...................(.(...((.......))...).)(.(.....).)....(((((.....(....)....))))) Models of ribosome-bound Dom34p and Rli1p and their ribosomal binding partners; 18S ribosomal RNA 3j2c M 462 13.2 RF00177,RF01959,RF01960 URS000080E148_562 23293003 0003735 0005840 562 gcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccu <<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<.<<<<....>>>>.>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<........>...<<<......>>>...>>>>>>.....<<<..<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>.........>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<..<.<<<<<<<........>>>>>>>>...>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>.. (((((.((..(((((..(((((((.(.......((........))..........(((((((..(...((((((([.(((((((....)))))))...((]...))..))))).))).((.(((...((((((......(((((((((....)))...(((......)))...)))))).....((((.(((((.(...((..(((.....)))))....).)))))......((((.....)))).........)))).......).)))...)).)))))....)))))))....)..))))))).(.....(((((.....(((..((...(((....)))...))....))).....)))))........(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...))))).. Dissecting the in vivo assembly of the 30S ribosomal subunit reveals the role of RimM; 16S rRNA head domain 3j2c N 927 13.2 RF00177,RF01959,RF01960 URS000080E21B_562 23293003 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggg .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<...<<..<<.<...<<<<<<<<........>>>>>.>>>.>..>>>>.......<<........<<<<<<...<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<...<<....>>.>>>>>.>>>>>>>..>..>>>>>>.<<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>.....<<<<<......<.<<<<<<..........>>.>>>>.>........>>>>>.......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<.<..<<<<<<<<...<<<......>>>......>>>>>>>>...>.......<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<....<<...<<<...........>>>...>>.>>>>>..........<<<<<<..<<<<<<<<<<<<.....>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<.......<<<<....>>>>.....>>..)))).]........ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..((...((.((..(((((.((((....)))).)).)))))..)).))......(((.......((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))).(((....(((..(((((((.........))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((.(.......))).)))).....)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((.(((((....(.((((((.....)))))))...))))).))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....(((((.....(...((((.........))))...)..)))))..........((((((..(((((((.((((.....)))).)))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].]........ Dissecting the in vivo assembly of the 30S ribosomal subunit reveals the role of RimM; 16S rRNA body domain 3j2c O 144 13.2 RF00177,RF01960,RF01959 URS000080E14E_562 23293003 0003735 0005840 562 uguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggauca .............<<...<.<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>.>....>>.........<<<<<<<<<....>>>>>>>>>...... ........(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))...... Dissecting the in vivo assembly of the 30S ribosomal subunit reveals the role of RimM; 16S rRNA body domain 3j3v A 2884 13.3 RF02540,RF02541,RF00002 URS00004D90A3_224308 23700310 0003735 0005840 224308 gguuaaguuagaaagggcgcacgguggaugccuuggcacuaggagccgaugaaggacgggacgaacaccgauaugcuucggggagcuguaagcaagcuuugauccggagauuuccgaauggggaaacccaccacucguaauggagugguauccauaucugaauucauaggauaugagaaggcagacccggggaacugaaacaucuaaguacccggaggaagagaaagcaaaugcgauucccugaguagcggcgagcgaaacgggauuagcccaaaccaagaggcuugccucuugggguuguaggacacucuguacggaguuacaaaggaacgagguagaugaagaggucuggaaaggcccgccauaggagguaacagcccuguagucaaaacuucguucucuccugaguggauccugaguacggcggaacacgugaaauuccgucggaauccgggaggaccaucucccaaggcuaaauacucccuagugaccgauagugaaccaguaccgugagggaaaggugaaaagcaccccggaaggggagugaaagagauccugaaaccgugugccuacaaguagucagagcccguuaacgggugauggcgugccuuuuguagaaugaaccggcgaguuacgaucccgugcaagguuaagcagaagaugcggagccgcagcgaaagcgagucugaauagggcgcaugaguacguggucguagacccgaaaccaggugaucuacccauguccagggugaaguucagguaacacugaauggaggcccgaacccacgcacguugaaaagugcggggaugagguguggguaggggugaaaugccaaucgaaccuggagauagcugguucucuccgaaauagcuuuagggcuagccucaagguaagagucuuggagguagagcacugauuggacuaggggccccuaccggguuaccgaauucagucaaacuccgaaugccaaugacuuauccuugggagucagacugcgagugauaagauccguagucgaaagggaaacagcccagaccgccagcuaaggucccaaaguauacguuaaguggaaaaggauguggaguugcuuagacaaccaggauguuggcuuagaagcagccaccauuuaaagagugcguaauagcucacuggucgagugacucugcgccgaaaauguaccggggcuaaacguaucaccgaagcugcggacuguucuucgaacagugguaggagagcguucuaagggcugugaagccagaccggaaggacugguggagcgcuuagaagugagaaugccgguaugaguagcgaaagaggggugagaauccccuccaccgaaugccuaagguuuccugaggaaggcucguccgcucaggguuagucgggaccuaagccgaggccgaaaggcguaggcgauggacaacagguugauauuccuguaccaccuccucaccauuugagcaauggggggacgcaggaggauaggguaagcgcgguauuggauauccgcguccaagcaguuaggcugggaaauaggcaaauccguuucccauaaggcugagcugugauggcgagcgaaauauaguagcgaaguuccugauuccacacugccaagaaaagccucuagcgaggugagaggugcccguaccgcaaaccgacacagguaggcgaggagagaauccuaaggugaucgagagaacucucguuaaggaacucggcaaaaugaccccguaacuucgggagaaggggugcucuguuagggugcaagcccgagagagccgcagugaauaggcccaggcgacuguuuagcaaaaacacaggucucugcgaagccguaaggcgaaguauaggggcugacgccugcccggugcuggaaccccaguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgacccgcacgaaaggcgcaacgaucugggcacugucucaacgagagacucggugaaauuauaguaccugugaagaugcagguuacccgcgacaggacggaaagaccccguggagcuuuacugcagccugauauugaauguugguacagcuuguacaggauagguaggagccuuggaaaccggagcgccagcuucgguggaggcaucggugggauacuacccuggcuguauugaccuucuaacccgccgcccuuaucgggcggggagacagugucaggugggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguucccucagaaugguuggaaaucauucgcagaguguaaaggcacaagggagcuugacugcgagaccuacaagucgagcagggacgaaagucgggcuuagugauccggugguuccgcauggaagggccaucgcucaacggauaaaagcuaccccggggauaacaggcuuaucucccccaagaguccacaucgacggggagguuuggcaccucgaugucggcucaucgcauccuggggcuguagucagucccaaggguugggcuguucgcccauuaaagcgguacgcgagcuggguucagaacgucgugagacaguucggucccuauccgucgcgggcgcaggaaauuugagaggagcuguccuuaguacgagaggaccgggauggacgcaccgcugguguaccaguuguucugccaagggcaucgcuggguagcuaugugcggacgggauaagugcugaaagcaucuaagcaugaagccccccucaagaugagauuucccauuccgcaaggaaguaagaucccugaaagaugaucagguugauaggucugagguggaaguguggcgacacauggagcugacagauacuaaucgaucgaggacuuaacca <<<<<<<<......<<<<<<<<<<<.....<<.<<<<<<<.<<<<<<......<<<<<<.....((.>>>.....<<<<<<<..<<<)).....>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<<<<<<<<.........>>>>>>>.>>.>>....<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<......<<.....>>.....>>>>...<<<....<<<<<<<<....>>>>>>>>......<<<.<<<<....................<..<<<<.<<<.....<<<........>>>.........<<<.......>>>...>>>...>>>>...>........>>>>...>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>.>>>>.>>>..............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>..<....<<<<..<<<<......>>>>..>>>>...<............>.<<<<<<....<<<<<<<.<<<<...<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.......>>>>.>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<......<.<<<<.<...<<<...<<<<<<<<...<<.<<<.......>>>..>>...>>>>>>>>..>>.>...>.>>>>.>......>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>....<<<......>>>....<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<...........<.......<<...........>>..............<<......>>....>.......>>>>>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>..<<<<<<...>>>>>>.....>>>>>><.<<<<<<<.<<......<<<<<..........>>>>>...>>.>>>>>>>..>.....>>>>>><......<.....<<<<<<.......>>>>>><<<<....<<<<<.<<<..<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>....<<<<........>>>>.))<<<<..<<<<<<...........<<<<....<<<<..<<<..<<<....<<<<<..[[[.....>>>>>.<<<.........<.<<<<<<<<.<<.....>>>>>>>>>.....>.>.........>>>........................>>>...>>>...>>>>.........>>>>......>>>>>>.>>>>>>>>.>>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<.<<..<<<....>>>.>>.>>>>>............<<<<<<<<<..<<...........>>..<<<<<<<.....<<<....>>>.......>>>>>>>..<<<<.<<<..<<<<<<<....>>>>>..>>>>>.<<<<<.......>>>>>.........<...........<<<<<.......>>>>>.....>....>>>>...>>.>>>>>>>.....>>.>>>>>>>>.>>>>.>.....>.(...<<<<<.......)>>>>>>.<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<.<<<<<<<<<<.............<.<<...<<.......<<<<<<<<....>>>>>>>>....>>.............>>>.....>>>>>>>>>>.>>>.......<<<<<<.....>>>>>>.......>>>>>>>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<.<<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.........<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>......>>>.......<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<....<<<...<<<<.<<<<<...]]]>>>>>...>>>>...>>>..>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>....<......>......<<<<<<<<<.......>>>>>....<<<<<<<..<<<....<<<<<....>>>>>...>>>...>>>>.>>>...>>>>....>>>>>>>>. ((((((((.......(((((((((.....(((..((((((.((((((......((((((..[..[[.)))....(((((((...(((]]..].).))......)))))).).)))....(((....)))((.((((......)))).)).(.(((((((.........)))))))..).))....((((((.....(...[..)......))))).).........((....))....(((......((.]...)).....)))....(((....((((((((....))))))))....(.(((....(.........................((.(((...(.(((........)))).[(...).(((.....].)))...)))...))..............)......))).....((((((((.........))))))))....).(((((..[[[[)))))..)))......)).)).)))).))...............((....))....))......(..((((....))))............)).....)))))))))......(.(((...((((......))))...))).[.(............).((((((....(((((((.(((....((....(((.....)))....))...((....))..((((.....))))........))).)))))))..((.(...((((((.....((((((((((.((((...(((.((......)).)))...).)))...(((.(((((.......{))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((......(.((((.....(((...((((((((....(.((.........))..)....))))))))..)).).....)))).)......))))))).))..((((.((.((......)).)).))))....(((......)))....(((.(((...((([[[...(.((((((.....(.....(...((((((((((..........(..................................................)......))))))))))..)...........]]].)...))))))))))...))))))...((((.....))))......))))))(.(((((.(.((.......(((............)))....))..))))))..).....))))))(......((....((((((.......))))))((((....(((...((..((.((((...((.....)).)))).)....[[((((.((...(((...(((....)))...)))...))....(((..........))).]]((((..((((((.......(...((((....((((..(((..(((....((..(..........)..)).(((...(.....(.((.((((..((.....)).)))).).....).)......)..)))......(.......).........)))...)))...))))(..).....))))..)...)))))).)))))))).))).....((......))..))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(....).....)))))(((.(.....(((....)))....).)))(...).......((((((.((...(...........)...((.((((.....(((....))).......)))).))..((((.((...(((((((....)))))..)).))(((((.........)))))........((..........(((((.......)))))..)..)....))))...))..)))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((...(((((((((.(((.(((...(.((....(...)....(.(....(((......(.((............)).)...)))..............)).....)).)...))).)))....(..((((((.....)))))).).....)))))))))....)))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).......][.[[[......)))))))...((((..((....{...))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..((((((((........)))))..))).(((((.....))))).....)))))..)...))).).....((((.((....))..))))..}.)...)))))))))))[...((((((....((((..(((((((.....(....)....))))))).(((((...((((...((((.(((.((....)).)))...))))...)))).)))))...(((.(...(((.............)))....)))).))))..].....))))))....(......)......((.((((((.......))))).....(((((((..((....(((((....)))))...))...))))).))....).))....)))))))). Atomic model of the immature 50S subunit from Bacillus subtilis (state I-a); ribosome RNA 23S 3j3v B 119 13.3 RF00001 URS00001CC3E3_224308 23700310 0003735 0005840 224308 uuugguggcgauagcgaagaggucacacccguucccauaccgaacacggaaguuaagcucuucagcgccgaugguagucggggguuucccccugugagaguaggacgccgccaagcaag <<<<<<<<<....<<<<<<<<.....<<<<<<.............>>>>..>>....>>>>>>.>>.<<...<...<<.<<<<<...>>>>>.>>.....>.>>..>>>>>>>>>.... .((((.((.....((((((((.....((((((...(.....)...))))..))....)))))).)).((........(.(((((...))))).)........))...)).))))..... Atomic model of the immature 50S subunit from Bacillus subtilis (state I-a); ribosome RNA 5S 3j5l A 2853 6.6 RF02540,RF02541 URS00004B0F34_83333 24662426 0003735 0005840 83333 gguuaacgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauggaaguguggacgccagucugcauggcuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<.>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<.........>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<..<<....>>..>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<..<<....>>...>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<.....<<<<<<<......>>>>>>>....>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>.>>>>>>. (((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((((((.)))).))...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((((.(....).)))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]]((((((((((.((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...)).....)))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((((.(...(.(((((......))))).)..).)))).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).)).)))))). Structure of the E. coli 50S subunit with ErmBL nascent chain; 23S ribsomal RNA 3j5l B 117 6.6 RF00001 URS0000366A67_83333 24662426 0003735 0005840 83333 gccugcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>.>>>>>. ((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))).))))). Structure of the E. coli 50S subunit with ErmBL nascent chain; 5S ribosomal RNA 3j5s E 77 7.5 RF00005 URS000041AF00_562 24389465,24389466 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... EttA binds to ribosome exit site and regulates translation by restricting ribosome and tRNA dynamics; P-site tRNA FMet 3j5y C 10 9.7 URS000080E2EA_9606 24335085 9606 auuguaaaaa .......... .......... Structure of the mammalian ribosomal pre-termination complex associated with eRF1-eRF3-GDPNP; 5'-R(*AP*UP*UP*GP*UP*AP*AP*AP*AP*A)-3' 3j5y D 88 9.7 RF00005 URS00000E7B03_9986 24335085 0030533 0006412 9986 gcggggguugccgagccuggucaaaggcgggggacucaagauccccucccguagggguuccgggguucgaauccccgcccccgcacca <<<<<<<..<<<.............>>><<<<<<.......>>>>>><<<....>>>...<<<<<.......>>>>>>>>>>>>.... (((((((..(((.......[.....)))((((((.......))))))(((....)))...(((((..]....)))))))))))).... Structure of the mammalian ribosomal pre-termination complex associated with eRF1-eRF3-GDPNP; tRNA-Leu 3j6b A 2713 3.2 RF02541,RF02540,RF02540,RF02540 URS000080DFEF_4932 24675956 0003735 0005840 4932 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(((((((((((((((.((......((((((((((((.....((((((((((....((((....((((((((..))))))))...(((((((((((.((((.......(.(((((...))))).)....))))..(((....)))....(((((((((..(.().)..))))))))).........((((((.....(......)......))))).).........((....))...(((.(.....((.....))....).)))....(((.........((((((.......))))))......((((..[[[[.))))..)))......))))))))).))..........((....))....)))).....)))))))))).....(.((((..(((((........)))))..)))).<.(.(........).).((((((....(((((((((((((..(((.....)))...................(((........)))..........)))))))))))))..((.(...((((((.....((((((((((.((((......).)))...(((..((((........)))).)))..).))))))))).(..((.....))....)..))))))......).))..((((((....(((((....)))))((((((((...(.((((((((((((((((())))))))))....(....(((...(((((((.(((((((.(.(()))..))))))))))))))..)).)....)..)))))))..)..)))))).))..((((((.(((......))).))))))....(((......)))...(((..(((...((([[[...(((((((.....((......(((((((((......)))).....((((((((..)))))))).)))))..........]]])).............)))))))(((((..))))).((((((((()))))))))..)))...))).)))((((((((((((....))))))))))))....))))))(.((((((......(.(((((((((...))))))))).)......))))))..).....))))))(......((....((((((......))))))((((....((((..(..(.......)..(((..[[.(((.(.(((.(....(((....)))..))))..))))...).))..((((((..(.(.....((.(((..()..))).)).(((((((((((..))))))))){{.{.))....).)........)))))).....]]....).....((......)).))))..((.......))...))))..((((....((((((((.((..(....(........((((....(.[...)......))).........)...((((((((...((.........))...(((((((.....(((.....))).......))))))).]((((.(((..((((((((.(......(.((((((((....))))))))).[....)))))))..)))))(((((........)))))........((..........(((((.......)))))..)..)....)).))..)).))))))..)..))).)))))))).)))))).....)).[..(((((.....>].)))))..((((((((.(((.(((...((((((.((((((..(((((.((((((.](((.(((((((((((..(.....).)))))))))))...(((((((((.(....).).)).(((((((((((((()))))))))))))).))))))....)))))))))..)))))..((((.))))((((((...........))).)))([((....((......(((....)))..........(((((((.....)))))))....)).....((((((((((((..))))))))))))...............(..((((((....(((((.......)))))((...((((((.))))))..))......((][.[[[))....)))))).)...((((..(((...{..)))..)))).(((....))).))]]].]......((((((.((..]]]]..)))))))).....)}......))))..)))))))..((((.(.(((((....((.......))....)))))...)))).).)(((((.((((((..(((((((((.......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))...)))..))))))))))).....(((((...(((((..(((((((.....(....)....)))))))((((((...((((....((((((((((((((...(((...((.).)...))).......(...}.}}.)......)).))))))))..))))....)))).))))))...((....((((..............))))....))..)))))...)))))..(..((((((((((.......)))))........(((((((.....((...(((((()))))).))....).))).)))....)))))).)))))))))))))).))))))))))))))).. Structure of the yeast mitochondrial large ribosomal subunit; 21S ribosomal RNA 3j6b e 20 3.2 URS000080DFD0_4932 24675956 4932 gcccgggaguccgggcacca <<<<<......>>>>>.... ((((((....)))))).... Structure of the yeast mitochondrial large ribosomal subunit; E-site tRNA 3j6x 2S 3308 6.1 RF02540,RF02543 URS000080E1A1_580240 24927574 0003735 0005840 580240 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........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((.(.(((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))).).....)))))))))))...)....(((((((........))))))).....(((((...[[.[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((......((..................))..(((((((((((((((((((((((.......(((((((......((((((....)))))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).<((((........))))((((((....(.((((.((((((..(((...((((.....))))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).)))).)..((.(...((((((.....(((((((((..(((....(((((((....))))))).....)))...(((..((.((........)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...((((((.....)))))).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.......(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))((((((((((.((......((((.((((....))))))))...)))))))))).)).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....))).........(...(((...)).)....)....))....))...(((((........)))))]]((((..(((.(((...((((....)))...(.[.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....)))...))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((......((.(.(.((....(.......(........).......).)).).......((.(.....).))..).))...........)))..)))))).))(...).......(((((((((...((.........))...(((((((....((((.....))))......))))))).].(.(.(((..((((((.(...(......((((....))))......).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....).)....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.((((((((..((.((((......((..............(..........................).....).)......)))).))....((((.....((((..((((........))))...........]...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]].]].))))))))))....)}....))))..)))))).......(..(.(.((((((...((.......))...))))))...))...)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))....))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.............))))...)))).))))....)))))))).......(((((..(((.((....((.(........(((((((..).)))))).....))).......((.(((....(.((.(..(((......)))..).)).)..))).)).............)).)))..)))))..(((((.(..(.......)..)...(.((((((.((.((.....((((.(..(.((((..)..))).)..)))))....))....)).).)))))).))))).. S. cerevisiae 80S ribosome bound with Taura syndrome virus (TSV) IRES, 5 degree rotation (Class II); 25S ribosomal RNA 3j6x 8S 158 6.1 RF00002 URS00001BF64E_580240 24927574 0003735 0005840 580240 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... S. cerevisiae 80S ribosome bound with Taura syndrome virus (TSV) IRES, 5 degree rotation (Class II); 5.8S ribosomal RNA 3j6x 5S 121 6.1 RF00001 URS000055688D_580240 24927574 0003735 0005840 580240 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(.(((..((....)).))).).....))))))))))))))). S. cerevisiae 80S ribosome bound with Taura syndrome virus (TSV) IRES, 5 degree rotation (Class II); 5S ribosomal RNA 3j6x 1S 1781 6.1 RF01960,RF01959,RF00177 URS000080E2D9_580240 24927574 0003735 0005840 580240 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S. cerevisiae 80S ribosome bound with Taura syndrome virus (TSV) IRES, 5 degree rotation (Class II); 18S ribosomal RNA 3j6y 2S 3308 6.1 RF02540,RF02543 URS000080E1A1_580240 24927574 0003735 0005840 580240 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........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))))....)))))))))))...)....(((((((........))))))).....((.((..[[[[[[)).))..)))..................................((....))............(..((((....))))............).....................(((((.((((((..............................(((((((((((((((((.(((((.......(((((((......((((((....)))))).......))))))).....)))))..)))))))))........(((....)))....))))))))....)))))).))))).<((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((...((((....))))....))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...).)))...(((..((.((........)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).).(((((((((...(((.(((((((.....(((....(((..(.((((...((((((.....)))))).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).)...((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.......(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))((((((((((.((......((((.((((....))))))))...)))))))))).)).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....))).........((..((.....).)..)).....))....))...(((((........)))))]]((((..(((.(((...((((....)))...(.[.((((((...((((.((((((((((((((.(((...{{..))).))(...(((((....(((((.....(((.....))).....))))).....)))))....).((((((......)))))).)))).).))))))).))))(...)....))))))...))....)))...))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((......(((....(.....(...(...(........)....)..)..)............(.....)......)))...........)))..)))))).))(...).......(((((((((...((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(...(......((((....))))......).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.((.(((((..(((((((.((...((..(.............(..((....)).............)....).).)...)).)))))))....((((.....((((..((((........))))...........]....(((((....)))))...))))..))))......))))).))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......(..(.(.((((((...((.......))...))))))...))...)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))....))..))).)))))....((((((((..(((..(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.............))))...))))..)))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(.(.((..)..).).)..)))))...)))....)))).)))))).))))).. S. cerevisiae 80S ribosome bound with Taura syndrome virus (TSV) IRES, 2 degree rotation (Class I); 25S ribosomal RNA 3j6y 8S 158 6.1 RF00002 URS00001BF64E_580240 24927574 0003735 0005840 580240 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... S. cerevisiae 80S ribosome bound with Taura syndrome virus (TSV) IRES, 2 degree rotation (Class I); 5.8S ribosomal RNA 3j6y 5S 121 6.1 RF00001 URS000055688D_580240 24927574 0003735 0005840 580240 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu .<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). S. cerevisiae 80S ribosome bound with Taura syndrome virus (TSV) IRES, 2 degree rotation (Class I); 5S ribosomal RNA 3j6y 1S 1781 6.1 RF01960,RF01959,RF00177 URS000080E2D9_580240 24927574 0003735 0005840 580240 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucau ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[..................<<....<<.<<<.....>>>.>>.....>>.........<<<<<..<<....>>..>>>>>[...((((((......<<<<<<<.<<......>>..............)))))).....]...<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<<<<<<<<<....>>>>>>>>>>.>>>......<<.................>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[<<.......{{...[[[.[[....<<<<<<.<<<<<....<..>....>>>>>.>>>>>>.....<<<<<...............................>>>>>....<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[...(((((((......>>>>>>>..)))))))..]].....]]....<<<<<.<<<...<<<<..<<<.<<<<<<.<...<<<......>>>......>.>>>>>>.>>>.......<<....>>...>>>>..>.>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..>>>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<......<<<<<........<<.<<<........>>>.>>......>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>>......>>>>>...>>.>>>>.>>>.....<<<<<<<.......<.....<<..<<<<....>>>>..>>....>........>>>>>>>......<....<<<<<<..........>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<.......<.......>........>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>....... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[[[[[[.(((....))).....(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.(((......)))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....((..(((((............)))))...))......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.((((.....(()).....)))).))))))....(.((((...............................)))).)...((((..((.......((..((.......)).(((.....)))....))......))..)..))).........(....(.((.(((.....]]]]]]].))).)).)...).....))...(((..((.((...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)).))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((.(.((..((((..(((((..(((((....)))))....)))))..)))).))..(.((((((.....))))))....)..).)))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((.....(((.....((..((((....))))..))....)))......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(..(((((((.(((..(.((..(...((.(((..........................))).))...)..)).)..))).))))))).)..)).))))...).))...)..)..(((((((((....)))))))))>...... S. cerevisiae 80S ribosome bound with Taura syndrome virus (TSV) IRES, 2 degree rotation (Class I); 18S ribosomal RNA 3j77 1S 1781 6.2 RF01960,RF01959,RF00177 URS000080E2D9_4932 25043550 0003735 0005840 4932 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucau ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[..................<.....<<.<<.......>>.>>......>.........<<<<<...<....>...>>>>>[...((((((......<<<<<<<<<<......>>..............)))))).....]...<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<<<<.<<........>>.>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.[[....<<<<<<.<<<<<....<..>....>>>>>.>>>>>>....<<<<<<......<.<.............>..>.....>>>>>>....<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>..........[....(((((((.....>>>>>>>>..)))))))...].....]]....<<<<<<.<<...<<<<..<<<.<<<<<<.<...<<<......>>>......>.>>>>>>.>>>.......<<....>>...>>>>..>.>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<....<<..<<<<<.<<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<<<<<<<.....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<..<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>........>>>>.....>>.>>>...>.>>>>>>>.....>.>>>>>...>>.>>>>.>>>.>...<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>.....<<<<<<<<.......>>>>>>>>......>>.....>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<......<<<<<<<........................>>>>>>>......>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>....... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((.....(..........)....)){))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[[[[[[[(((....))).....(......).)))))).)...).(.((((..((.(..)..)).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....((..(((................)))...))......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.((((......()......)))).))))))....((((((...............................))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(....(.((.(((....]]]]]]]].))).)).)...).....))...(((.(((.((...((((..(((.((((((.(...((........))......).)))))).))).......((....))...))))..)).)))..))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((...(((((((.(((........))))))))))...)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.((((((...((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((.....(((.....((..((((....))))..))....)))......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))....))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...((((((..........................))))))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>...... Structures of yeast 80S ribosome-tRNA complexes in the rotated and non-rotated conformations (Class II - rotated ribosome with 1 tRNA); 18S ribosomal RNA 3j77 2S 3287 6.2 RF02540,RF02543 URS000080E1A1_4932 25043550 0003735 0005840 4932 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Structures of yeast 80S ribosome-tRNA complexes in the rotated and non-rotated conformations (Class II - rotated ribosome with 1 tRNA); 25S ribosomal RNA 3j77 8S 158 6.2 RF00002 URS00001BF64E_4932 25043550 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((...(.]].)..........).)))..)...)))....((.....))(((((((((....)))))))))..................... Structures of yeast 80S ribosome-tRNA complexes in the rotated and non-rotated conformations (Class II - rotated ribosome with 1 tRNA); 5.8S ribosomal RNA 3j77 5S 121 6.2 RF00001 URS000055688D_4932 25043550 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Structures of yeast 80S ribosome-tRNA complexes in the rotated and non-rotated conformations (Class II - rotated ribosome with 1 tRNA); 5S ribosomal RNA 3j77 PT 77 6.2 RF00005 URS000041AF00_562 25043550 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Structures of yeast 80S ribosome-tRNA complexes in the rotated and non-rotated conformations (Class II - rotated ribosome with 1 tRNA); P/E-site initiator transfer RNAfMet 3j78 1S 1781 6.3 RF01960,RF01959,RF00177 URS000080E2D9_4932 25043550 0003735 0005840 4932 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...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[..................<.....<<.<<.......>>.>>......>.........<<<<<...<....>...>>>>>....((((((......<<<<<<<<<<......>>..............)))))).........<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<<..>>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<..<<<<..............>>>>...>>......<<<.<...........>>.>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.[[....<<<<<<.<<<<..............>>>>.>>>>>>....<<<<<<............<......>...........>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[...((((((((....>>>>>>>>.))))))))..]].....]]....<<<<<<.<<...<<<<..<<<.<<<<<<.<...<<<......>>>......>.>>>>>>.>>>.......<<....>>...>>>>..>>.>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<............................<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<<<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>...>.>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<......<<..<<<<....>>>>..>>.....>.......>>>>>>>......<....<<<<<<..........>>>>>>....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<....<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<..........................>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>.....>>...>.....<<<<<<<<<<..>>>>>>>>>>....... 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Structures of yeast 80S ribosome-tRNA complexes in the rotated and non-rotated conformations (Class I - non-rotated ribosome with 2 tRNAs); 18S ribosomal RNA 3j78 2S 3302 6.3 RF02540,RF02543 URS000080E1A1_4932 25043550 0003735 0005840 4932 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Structures of yeast 80S ribosome-tRNA complexes in the rotated and non-rotated conformations (Class I - non-rotated ribosome with 2 tRNAs); 25S ribosomal RNA 3j78 8S 158 6.3 RF00002 URS00001BF64E_4932 25043550 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<<((....>>>>.....<.<<<<.....))............>.>>>..>...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Structures of yeast 80S ribosome-tRNA complexes in the rotated and non-rotated conformations (Class I - non-rotated ribosome with 2 tRNAs); 5.8S ribosomal RNA 3j78 5S 121 6.3 RF00001 URS000055688D_4932 25043550 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Structures of yeast 80S ribosome-tRNA complexes in the rotated and non-rotated conformations (Class I - non-rotated ribosome with 2 tRNAs); 5S ribosomal RNA 3j78 ET 77 6.3 RF00005 URS000041AF00_562 25043550 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Structures of yeast 80S ribosome-tRNA complexes in the rotated and non-rotated conformations (Class I - non-rotated ribosome with 2 tRNAs); P/E-site initiator transfer RNAfMet 3j78 PT 77 6.3 RF00005 URS000041AF00_562 25043550 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Structures of yeast 80S ribosome-tRNA complexes in the rotated and non-rotated conformations (Class I - non-rotated ribosome with 2 tRNAs); P/E-site initiator transfer RNAfMet 3j79 A 3191 3.2 RF02540,RF02543 URS000080E1CC_36329 24913268 0003735 0005840 36329 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Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine, large subunit; 28S ribosomal RNA 3j79 B 118 3.2 RF00001 URS000080E122_36329 24913268 0003735 0005840 36329 gacucguucauacuacaguggauacaccagaucccaucagaacucugaaguuaagcacuguaaggcuuggcuaguacugaggugggagaccgcucgggaacaccaggugaugagucag <<<<<<<<....<<<<<<<<.....<<<<<<............>>>>..>>....>>>>>>.>><<<<<<......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>.. ((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......(((((..((....)).))))).....)))))))))))))).. Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine, large subunit; 5S ribosomal RNA 3j79 C 151 3.2 RF00002 URS00005DAD5E_36329 24913268 0003735 0005840 36329 agcacagucuuaacgauggaugucuugguuccuacagcgaugaaggccgcagcaaaaugcgauacgcaaugaaaauugcagugacugaaucaucagaaugcugaauguaaacuacaccaauucccugggaauagugguacuccuacagaaa ............................................<<<<<<.((.....>>>.....<.<<<<..<<.)).>>.......>>>>..>...>>>....<<.....>><<<<<<<<<<.>>>>>>..>>>>............. ............................................((((((.[[.....))).....(.((((..((.]].)).......))))..)...)))....((.....))((((((((((.))))))..))))............. Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine, large subunit; 5.8S ribosomal RNA 3j7a A 1608 3.2 RF01960,RF01959,RF00177 URS000040971D_36329 24913268 0003735 0005840 36329 aaccugguugaucuugccaguagucauaugcuugucucaaagauuaagccaugcaagugaaaguauauauauauauauguagaaacugcgaacggcucauuaaaacaguuauagucuacuugacauuuauaaggauaacuacggaaaagcuguagcuaauacuugcauuauccuuuuggauaaguauuuguuagaaggaauuauaacaaagaaguaacacguaaaguguguaucaaucgaguuucugaccuaucagcuuuugauguuaggguauuggccuaacauggcuaugacggguaacggggaauuagaguucgauuccggagagggagccugagaaauagcuaccacaucuaaggaaggcagcaggcgcguaaauuacccaauucuaaagaagagagguagugacaagaaauaacaaugcaagguuuguauuggaauggugggaauuuaaaaccuucccagaguaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaauuguugcaguuaaaacgcucguaguugaauuucaaagaaucauucuuuuuaaaauccggauuuguuacuuugaguaaauuagaguguucaaagcaaacaguuaaagcauuguguuugaauacuauagcauggaauaacaaaauugaacaagcuaaaauuuuuuguucuuauuuuggcuuaguuacgauuaauaggaguagcuuggggacauucguauucagaugucagaggugaaauucuuagauuuucuggagacgaacaacugcgaaagcauuugucuaaaauacuuccauuaaucaagaacgaaaguuaagggagugaagacgaucagauaccgucguaaucuuaaccauaaacuaugccgacuagguguuggaugaagugcuuccuucaguaccuuaugagaaaucaaagucuuuggguucuggggcgaguauucgcgcaagcgagaaaguuaaaagaauugacggaagggcaccaccaggcguggagcuugcggcuuaauuugacucaacacggggaaacucacuaguuuaagacauuggauggugaugcauggccguuuuuaguucgugaaugauuugucugguuaauuccgauaacgaacgagaucuuaaccugcuaauuagcggcgaguacacuguacuugcugcuucuuagaggaacauugugugucuaacacaaggaaguuuaaggcaacaacaggucugugauguccuuagaugaacuaggcugcacgcgugcuacacugauauauauaacgaguaaaauaugcuugcauacuuuuccuccgccgaaaggcguagguaaucuuuaucaauauauaucgugauggggauagauuauugcaauuauuaaucuugaacgaggaaugccuaguaagcaugauucaucagauugugcugacuacgucccugcccuuuguacacaccgcccgucgcuccuaccgauugaaagauaugaugaauuguuuggacaagaaaaauuuuuucuggaaaaaccguaaauccuaucuuuuaaaggaaggagaagucguaacaagguuuccguaggugaaccugcggaaggaucau 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...((((..[.[[[..))))((((.((((((...(((...((.....(((.(((..((....((...((((((()))))))...))[))......(((.......(((..((..((...((((....[...((.....((.(((.....))).))......))....((((((....))))))...(((((((.(......).))))))).....(](((.(..)))))...))))..))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)....))).....(((((((((.)))))))))....(.((((((.........))))))......)..((((([[....(.((((.....((..]])).......))))))))))..))))))))))..[......((([[...(.(.((...(((.((....(((..(....)..)))..(((((())))))((((((.((.......((..((.......)).(((.......(((.))))))....))......)).))..)))).....(..((.(..(.(((.(..........).))).)..).))...).))...(((((((..((..(((((..(((.((((((.....((........))........)))))).))).......((....))...))))).)).))).)))..))))...)).)....((((((...((...((((.........))))...))))))))......{...(((.((.((((((((((.((((())))).))))))))))...((..]]))...))...].))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((((....(...)...((.(((...(.((((((....(((((((((...)))..(.((......)))...)))))).....((((.(.(..(((..((.(((((((((...))))))))).))..))).).)..(.((((((.....))))))....)..)))).....))).))).....).))))).....)))))))...)).)))).))).(...((((((.......((...(.(((((..))))).)...((..((((....))))..))....)).........))))))......(....(((.((..........)).)))....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(.(((((.((..(.((.(((((.(((..((.((((...(...((((.))).)...)...)))).))..))).))))).)))..)).)))))..).))...)..)..(((((((((....)))))))))}...... Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine, small subunit; 18S ribosomal RNA 3j7a 7 74 3.2 RF00005 URS000035398D_36329 24913268 0030533 0006412 36329 ggguaauuggcgcaguugguuagcgcgcgggucucauaaucccgaggucgugaguucgauccucacauuaccca .<<<.....<<...........>>..<............>......<..<<.......>>..>...>>>..... .(.(.....((...........))(.(............).)....(..((.......))..)...).)..... Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine, small subunit; tRNA 3j7o 5 3662 3.4 RF02540,RF02543 URS000080DE35_9823 24930395 0003735 0005840 9823 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcggcccggcggaucuuucccgcgcgggggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucggccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcgcucuccccccucccggcgccgccggggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccgggggaggggccacgcgcgcgucccccgaagagggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcacacgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcgugagccgggcguggaauggagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagcggcgggggcggcgcgcgcgcgcgcccgcccccggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcugggucggucgucggccggcgccuagcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacauguuuuuucacugacccggugaggcgggggggcgagccccgaggggcucucgcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccggucccccgcgggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcacgccguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu ..........................<<<<<.....<......>......>>>>>...........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<<...<<<<<<<<<<<...>>>>>>>.>>>>.....>>>>>..<<<<<<<<<....<<<<<<<<........<<<<<<<.....<<<<......>>>>.....((......<<<.....))>>>.....>>>>>>>...>>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..(((((.>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<.......<<<<<<<.<<<.....<<<<<<<<<<<...<<<....<<<<<.<<....<<<<.<<<..<<<<<>>>>>>>>>>>>>>>>.>>>......>>>.>>>>>>>>>>>......>>>.>>>.>>>>...<<<<<<<..<<<<<<<<<..<<<....<...<<.<<<.<<<<...<<.<<<<<..>>>>>>.>....>>>>.>>>>>.........>.>>>....>>>>>>>>>.....................<<<<..<<<<<<...<<<<<.>>>>>.>>>>>>....<<<.<<<<.<<<<<<<<<<<<<<<<<<<<<<<<.<<<<....>>>>.>>>>>>>>>>>.>>>>>>>>>>.>>>...>.>>>...>>>........<<<<<<<<.....>>>>>>>>........>>>>........>>.>>>>>....>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<<....>>>>>>>>..<<<<<...<<<..<<<...(((..[[.>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<......<<<....>>>..<<.<<<<<<<............<<<<<<<<<...<<<....<<<....<<<..<.<<<<.<.....>.>>>>>.>>>....>>>..>.>>...>>>>>>>...<<<<<<<<<........>>>>>>>>>...>>...>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<..........]]..))).......................<<<..>>>.......................>>>>>>>>>....>>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<<<<<...>>>>>>>>>>>......>>....>>...<<<<<........>>>>>))<<<<....<<<<...<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<<<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>.>.>>>>>>>>>>>>.........>>>>>>>..>............>>>>.>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>.>>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<.<<<<<.<<<<<...<<<<<<.>>>>>>........>>>>>...>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<......<.....<<<<....>>>>.....>...>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<..<<<<<<<<<.<<<<<<<<<<..>>>>>>>>>>...<<<<<.....<<<<..<<.<<<<<<....>>>>>>>>..............<<<<<<<<<<<.....>>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>...>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<....<<<<<<.......>>>>>>.....<<.[.(((>>.....>>>>>>...<<<..<<<<.......>>>>..>>>.<<<....>>>.>>)))].....<<<<<<<..<<<...))))).>>>>>>>>>>.........>>>>..>>>>>>.......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<...<<<.<<<<<<.]]]..>>>>..>>.>>>..>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.....<<<<<<<.<<..<<<.....<<.........<<<<<..<<<<..>>>>.>>>>>........>>....<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>..............>>>..>>>>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<....<<<<<......>>>>>...>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(.(((......(...[..).......)))..).........((....))...((((......((.]...)).....))))...((((...((...((((.(((((((...)))))))..)))....).))....((((...((....((((((((........(((((((...({((((......)))))....[[(...).(((....}]]))).....)))))))...))))))))...))...))).).)....((((.((........)).)))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.......(((((((.((......(((((((((((...(((....(((((.((....((((.(((..((((()))))))))))))))).)))......))).))))))))))).......)).))).))))...((((((((.((((.(((((.(((....(...(.((((.((((.........((()))..........)))).))))).........).)))...))))).))))....................(((((..((((((...(((((.))))).))))))..((....((((.((((((((((((((((((((((((.((((....)))).)))))))))).))))))))))).)))...).))).....)..).....((((((((.....))))))))........)))))......))).)))))....)))...)))))))).[((((........))))((((((....((((((((.((((..(((...((((........)))).....)))...(......)...((((((((....))))))))..(((((...(((..(((....[[...[.)))..)))....))))).(((((.(((..(((......))).))).))).))....)))).))))))))..((.(...((((((.....(((((..((..((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))....))..))))).(.((.......))...)..))))))......).))..((((((.....(.((....)))..((.(((.(((............(.((((((....(((....(((..(.(((....((((.(.....).))))..))).)..)))..)).)....))))))...(((((((((........)))))))))....)...))).)))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.((((.......(..........(((...((((((((.....{...(((.(((...((.........))...))).....(...((......)).).))).....))))))))..)))..........]]].).....)))))))))...)))))))...(((.(((..........]...]]........................(((..))).......................)))))).......)))))).(.(.((((((.((......(((..((((....)))).)))...)))))))).)..).....))))))((.....((.....((((((.......)))))).(.(.....((((..((...((((((...((.....)).))))))....[[(((.((...((....(((....)))..........((.((((((.((...)).))))))))......))....))...(((((........)))))]]((((....(((.....((.((((....)))).))..(.((....))....(...((((((...(.((((((((((((((((((((....{{...)))))....(.....((((.((((.....(((.....))).....))))))))......).....((((((((....).))))))))))).).)))))))))).)(...)....))))))...))............))).)))).)))..))......(......)..)))).((((.....))))..).)....((((.....(((((.(.((..(....(.......(((((....(.[..).....)))))((.((((..(((((...((((((.))))))........)))))....)))).))(...).......(((((((((.>.((.........))...(.(((((....((((.....))))......))))).).]...(.(((..((((((.(...........(((....))).........)))))..)))))..(((.........)))..........((............((.........))....)..)....)......)).))))))).)..))).).)))))..))))))....)).{..(((((.....]}.)))))....(((((..(...((.......(((.((((((..(((((...(((((...(((((.((((..)))).)))))...(.........((((.....((((((....))))))................(((((((((((.....)))))))))))..))))......)......)))))....)))))..(((.......)).)((((((...........))))))(......(((((...(.((((((.......))))))...)......[[.........)))).)(.(((..((((....{..))))..))))(((....)))....]].......((.(((...((..]]]]]].)).))).))....)}....))))..)))))........((.(.(.((((((...((.......))...))))))...)).).)........((...((((((......((((.......).))).......(((.(.....).))).....)))))..).....).).....(((.(((....)))..)))..a.))....).))))).....(((.(..(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}..)))))..)).))...))))...)))).((((...((((.....}.......))))...))))..)))...).)..)))......(((((......(((.....((..........((((..((((())))).)))).........))........((((....((((.(((((((......)))))))))))...))))..................))).....))))).(((((.(..(.......)..)....((.(((.(((.((......(((.(..(((((......)))))..)))).....))....)))..))).))..))))).. Structure of the mammalian 60S ribosomal subunit; 28S ribosomal RNA 3j7o 7 120 3.4 RF00001 URS000002B0D5_9823 24930395 0003735 0005840 9823 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. ((((((.......((((((((.....((((((...(....)...))))..))....)))))).))(((.((......((.((..((....)).)).)).....)).)))...)))))).. Structure of the mammalian 60S ribosomal subunit; 5S ribosomal RNA 3j7o 8 156 3.4 RF00002 URS00004B2C76_9823 24930395 0003735 0005840 9823 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<.<<.....>>>.......<<<......>>.............>>>......>>>....<<<..>>><<<<<<<<.......>>>>>>>>.................... .........................................(.((((.[[.....))).......(((......]].............)))......).)....((....))((((.(((.......))).)))).................... Structure of the mammalian 60S ribosomal subunit; 5.8S ribosomal RNA 3j7p 5 3662 3.5 RF02540,RF02543 URS000080DE35_9823 24930395 0003735 0005840 9823 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcggcccggcggaucuuucccgcgcgggggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucggccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcgcucuccccccucccggcgccgccggggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccgggggaggggccacgcgcgcgucccccgaagagggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcacacgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcgugagccgggcguggaauggagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagcggcgggggcggcgcgcgcgcgcgcccgcccccggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcugggucggucgucggccggcgccuagcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacauguuuuuucacugacccggugaggcgggggggcgagccccgaggggcucucgcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccggucccccgcgggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcacgccguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu ..........................<<<<<.....<......>......>>>>>...........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<<...<<<<<<<<<<<...>>>>>>>.>>>>.....>>>>>..<<<<<<<<<....<<<<<<<<........<<<<<<<.....<<<<......>>>>.....((......<<<.....))>>>.....>>>>>>>...>>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..(((((.>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<.......<<<<<<<.<<<.....<<<<<<<<<<<...<<<....<<<<<.<<....<<<<.<<<..<<<<<>>>>>>>>>>>>>>>>.>>>......>>>.>>>>>>>>>>>......>>>.>>>.>>>>...<<<<<<<..<<<<<<<<<..<<<....<...<<.<<<.<<<<...<<.<<<<<..>>>>>>.>....>>>>.>>>>>.........>.>>>....>>>>>>>>>.....................<<<<..<<<<<<...<<<<<.>>>>>.>>>>>>....<<<.<<<<.<<<<<<<<<<<<<<<<<<<<<<<<.<<<<....>>>>.>>>>>>>>>>>.>>>>>>>>>>.>>>...>.>>>...>>>........<<<<<<<<.....>>>>>>>>........>>>>........>>.>>>>>....>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<<....>>>>>>>>..<<<<<...<<<..<<<...(((..[[.>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<......<<<....>>>..<<.<<<<<<<............<<<<<<<<<...<<<....<<<....<<<..<.<<<<.<.....>.>>>>>.>>>....>>>..>.>>...>>>>>>>...<<<<<<<<<........>>>>>>>>>...>>...>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<........<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>....>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<..........]]..))).......................<<<..>>>.......................>>>>>>>>>....>>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<<<<<...>>>>>>>>>>>......>>....>>...<<<<<........>>>>>))<<<<....<<<<...<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<<<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>.>.>>>>>>>>>>>>.........>>>>>>>..>............>>>>.>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>.>>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<.<<<<<.<<<<<...<<<<<<.>>>>>>........>>>>>...>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<......<.....<<<<....>>>>.....>...>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<..<<<<<<<<<.<<<<<<<<<<..>>>>>>>>>>...<<<<<.....<<<<..<<.<<<<<<....>>>>>>>>..............<<<<<<<<<<<.....>>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>...>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<....<<<<<<.......>>>>>>.....<<.[.(((>>.....>>>>>>...<<<..<<<<.......>>>>..>>>.<<<....>>>.>>)))].....<<<<<<<..<<<...))))).>>>>>>>>>>.........>>>>..>>>>>>.......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<...<<<.<<<<<<.]]]..>>>>..>>.>>>..>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.....<<<<<<<.<<..<<<.....<<.........<<<<<..<<<<..>>>>.>>>>>........>>....<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>..............>>>..>>>>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<....<<<<<......>>>>>...>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(.(((......(...[..).......)))..).........((....))...((((......((.]...)).....))))...((((...((...((((.(((((((...)))))))..)))....).))....((((...((....((((((((........(((((((...({((((......)))))....[[(...).(((....}]]))).....)))))))...))))))))...))...))).).)....((((.((........)).)))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.......(((((((.((......(((((((((((...(((....(((((.((....((((.(((..((((()))))))))))))))).)))......))).))))))))))).......)).))).))))...((((((((.((((.(((((.(((....(...(.((((.((((.........((()))..........)))).))))).........).)))...))))).))))....................(((((..((((((...(((((.))))).))))))..((....((((.((((((((((((((((((((((((.((((....)))).)))))))))).))))))))))).)))...).))).....)..).....((((((((.....))))))))........)))))......))).)))))....)))...)))))))).[((((........))))((((((....((((((((.((((..(((...((((........)))).....)))...(......)...((((((((....))))))))..(((((...(((..(((....[[...[.)))..)))....))))).(((((.(((..(((......))).))).))).))....)))).))))))))..((.(...((((((.....(((((..((..((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))....))..))))).(.((.......))...)..))))))......).))..((((((.....(.((....)))..((.(((.(((............(.((((((....(((....(((..(.(((....((((.(.....).))))..))).)..)))..)).)....))))))...(((((((((........)))))))))....)...))).)))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.((((.......(..........(((.(.((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))).))))..........]]].).....)))))))))...)))))))...(((.(((..........]...]]........................(((..))).......................)))))).......)))))).(.(.((((((.((......(((..((((....)))).)))...)))))))).)..).....))))))((.....((.....((((((.......)))))).(.(.....((((..((...((((((...((.....)).))))))....[[(((.((...((....(((....)))..........((.((((((.((...)).))))))))......))....))...(((((........)))))]]((((....(((.....((.((((....)))).))..(.((....))....(...((((((...(.((((((((((((((((((((....{{...)))))....(.....((((.((((.....(((.....))).....))))))))......).....((((((((....).))))))))))).).)))))))))).)(...)....))))))...))............))).)))).)))..))......(......)..)))).((((.....))))..).)....((((.....(((((.(.((..(....(.......(((((....(.[..).....)))))((.((((..(((((...((((((.))))))........)))))....)))).))(...).......(((((((((.>.((.........))...(.(((((....((((.....))))......))))).).]...(.(((..((((((.(...........(((....))).........)))))..)))))..(((.........)))..........((............((.........))....)..)....)......)).))))))).)..))).).)))))..))))))....)).{..(((((.....]}.)))))....(((((..(...((.......(((.((((((..(((((...(((((...(((((.((((..)))).)))))...(.........((((.....((((((....))))))................(((((((((((.....)))))))))))..))))......)......)))))....)))))..(((.......)).)((((((...........))))))(......(((((...(.((((((.......))))))...)......[[.........)))).)(.(((..((((....{..))))..))))(((....)))....]].......((.(((...((..]]]]]].)).))).))....)}....))))..)))))........((.(.(.((((((...((.......))...))))))...)).).)........((...((((((......((((.......).))).......(((.(.....).))).....)))))..).....).).....(((.(((....)))..)))..a.))....).))))).....(((.(..(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}..)))))..)).))...))))...)))).((((...((((.....}.......))))...))))..)))...).)..)))......(((((......(((.....((..........((((..((((())))).)))).........))........((((....((((.(((((((......)))))))))))...))))..................))).....))))).(((((.(..(.......)..)....((.(((.(((.((......(((.(..(((((......)))))..)))).....))....)))..))).))..))))).. Structure of the 80S mammalian ribosome bound to eEF2; 28S ribosomal RNA 3j7p 7 120 3.5 RF00001 URS000002B0D5_9823 24930395 0003735 0005840 9823 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. ((((((.......((((((((.....((((((...(....)...))))..))....)))))).))(((.((......((.((..((....)).)).)).....)).)))...)))))).. Structure of the 80S mammalian ribosome bound to eEF2; 5S ribosomal RNA 3j7p 8 156 3.5 RF00002 URS00004B2C76_9823 24930395 0003735 0005840 9823 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<.<<.....>>>.......<<<......>>.............>>>......>>>....<<<..>>><<<<<<<<.......>>>>>>>>.................... .........................................(.((((.[[.....))).......(((......]].............)))......).)....((....))((((.(((.......))).)))).................... Structure of the 80S mammalian ribosome bound to eEF2; 5.8S ribosomal RNA 3j7p S2 1742 3.5 RF01960,RF01959,RF00177 URS000080E1CB_9823 24930395 0003735 0005840 9823 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucgcuccucucccacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgccccccguggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuccgcgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcgggcguccccgccgccucucggccggggcccgaagcauuuacuuugaaaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggucggcccacggcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<...((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<...<<<..........>>>..>>.>>......<<........<<<.<....<<....<<<<<..................<<.....<<.............>>......>>.........<<<<...<<<<<<....>>>>>>...>>>>....<<<<<...<......>..>>>>>...........<<<<.<<<<......>>>>>>>>.>>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>...<<....>>.....>>>>>>.........<<<....<<<.....>>>..>>>..>...>>.>.....<<<<<<.<..<<<....>>>..>..>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.........)).........>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<.....<<.<.<<....>>.>.>><<.<..<...........>>.>>..<<<<<<.<.......<<...<.......>.<<<<.......>>>>...>>......>.>>>..>>>.......<<....<<<<<<<...............>>>>>>>...>>....>>....<<<<<<..<...<<<<..<<<.<<<<<<<<...<<<......>>>......>>>>>>>>.>>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<....<...<<<<.<.....>.>>>>...>.>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..))))..<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<........<<........>>..........<<<<<......<<<<<........<...<<........>>...>......>>>>>...<<.<<<....<<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<.....<<<...<<<....>>>..>>>.....>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>...>...>>>>>.......>>>>>......>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>.........<..<<<<<..........>>>>>.>.........>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<....<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<.<<<<<<<<<<<<.....>>>>>>>>>>>>...>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>.....>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))(((.....((...(.((..((.....(((..((..((....((....((..........))...))[))......(((.......(((.(.(..((....(((((..................((.....((.(.(.....).).))......))..........(((...((((((....))))))...)))....(.((((.............)))))...........((((..(((......))).)))).)).)))...))).).))).(((....(((....((((((...........)))))))))......)))...(((.(.(.......))....)))))).((.(((..........))).))...((....)).....)).))).).....(.(((...(((..]....)).))))).)...)).).....((.((..(..(((....)))..)...))..))......((..(...........)..))..........(((([[......((((.....((..]])).......)))).))).)..)).....)))..[......(.([[...(.(.((...(((..(......(.(.((....)).).).((...................))..(((((..(.......((..(.........).(((.......)))....))......)..))..)))..........(..(.((.((...............)).)).).).......)....(((..(...(...((((..(((.((((((((...((........))......)))))))).)))..................))))..)...)...))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((....(((....((((((...............))))))....)))...((..]]))........].))))).).(((......((((....))))....)))...]]].](((((.(((((((..((...((((..(((.((((((......((........))..........(((((......((((..........(...............).........))))...((.(((...(.((((((....(((.(((((....)))..(..(......).)...)).)))....(((...(...((((..(((.....(((...(((....)))..))).....)))..))))..)..(..(((((.....)))))....)...)))....))).))).....).))))).......)))))...)).)))).))).(...(...((........(.......(((.((((....)))).)))....).........))...)......(.....(((((..........))))).....)..)..))).).....((((((.(.......).))))))......))...)))))))))).))..(.(..((.(..((((.((..(.(((((((..(((..((((.((...((.((.(((((((((.((.....)).)))))))))...)).))...)).))))..)))..))))))))..)).))))...).))...)..)..(.(((((((....)))))))).}........ Structure of the 80S mammalian ribosome bound to eEF2; 18S ribosomal RNA 3j7q 5 3662 3.4 RF02540,RF02543 URS000080DD6F_9823 24930395 0003735 0005840 9823 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcggcccggcggaucuuucccgcgcgggggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucggccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcgcucuccccccucccggcgccgccggggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccgggggaggggccacgcgcgcgucccccgaagagggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcacacgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcgugagccgggcguggaauggagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagcggcgggggcggcgcgcgcgcgcgcccgcccccggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcugggucggucgucggccggcgccuagcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacauguuuuuucacugacccggugaggcgggggggcgagccccgaggggcucucgcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccggucccccgcgggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcacgccguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu ..........................<<<<<.....<......>......>>>>>...........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<<...<<<<<<<<<<<...>>>>>>>.>>>>.....>>>>>..<<<<<<<<<....<<<<<<<<........<<<<<<<.....<<<<......>>>>.....((......<<<.....))>>>.....>>>>>>>...>>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..(((((.>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<.......<<<<<<<.<<<.....<<<<<<<<<<<...<<<....<<<<<.<<....<<<<.<<<..<<<<<>>>>>>>>>>>>>>>>.>>>......>>>.>>>>>>>>>>>......>>>.>>>.>>>>...<<<<<<<..<<<<<<<<<..<<<....<...<<.<<<.<<<<...<<.<<<<<..>>>>>>.>....>>>>.>>>>>.........>.>>>....>>>>>>>>>.....................<<<<..<<<<<<...<<<<<.>>>>>.>>>>>>....<<<.<<<<.<<<<<<<<<<<<<<<<<<<<<<<<.<<<<....>>>>.>>>>>>>>>>>.>>>>>>>>>>.>>>...>.>>>...>>>........<<<<<<<<.....>>>>>>>>........>>>>........>>.>>>>>....>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<<....>>>>>>>>..<<<<<...<<<..<<<...(((..[[.>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<......<<<....>>>..<<.<<<<<<<............<<<<<<<<<...<<<....<<<....<<<..<.<<<<.<.....>.>>>>>.>>>....>>>..>.>>...>>>>>>>...<<<<<<<<<........>>>>>>>>>...>>...>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<..........]]..))).......................<<<..>>>.......................>>>>>>>>>....>>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<<<<<...>>>>>>>>>>>......>>....>>...<<<<<........>>>>>))<<<<....<<<<...<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<<<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>.>.>>>>>>>>>>>>.........>>>>>>>..>............>>>>.>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>.>>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<.<<<<<.<<<<<...<<<<<<.>>>>>>........>>>>>...>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<......<.....<<<<....>>>>.....>...>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<..<<<<<<<<<.<<<<<<<<<<..>>>>>>>>>>...<<<<<.....<<<<..<<.<<<<<<....>>>>>>>>..............<<<<<<<<<<<.....>>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>...>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<....<<<<<<.......>>>>>>.....<<.[.(((>>.....>>>>>>...<<<..<<<<.......>>>>..>>>.<<<....>>>.>>)))].....<<<<<<<..<<<...))))).>>>>>>>>>>.........>>>>..>>>>>>.......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<...<<<.<<<<<<.]]]..>>>>..>>.>>>..>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.....<<<<<<<.<<..<<<.....<<.........<<<<<..<<<<..>>>>.>>>>>........>>....<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>..............>>>..>>>>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<....<<<<<......>>>>>...>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(.(((......(...[..).......)))..).........((....))...((((......((.]...)).....))))...((((...((...((((.(((((((...)))))))..)))....).))....((((...((....((((((((........(((((((...({((((......)))))....[[(...).(((....}]]))).....)))))))...))))))))...))...))).).)....((((.((........)).)))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.......(((((((.((......(((((((((((...(((....(((((.((....((((.(((..((((()))))))))))))))).)))......))).))))))))))).......)).))).))))...((((((((.((((.(((((.(((....(...(.((((.((((.........((()))..........)))).))))).........).)))...))))).))))....................(((((..((((((...(((((.))))).))))))..((....((((.((((((((((((((((((((((((.((((....)))).)))))))))).))))))))))).)))...).))).....)..).....((((((((.....))))))))........)))))......))).)))))....)))...)))))))).[((((........))))((((((....((((((((.((((..(((...((((........)))).....)))...(......)...((((((((....))))))))..(((((...(((..(((....[[...[.)))..)))....))))).(((((.(((..(((......))).))).))).))....)))).))))))))..((.(...((((((.....(((((..((..((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))....))..))))).(.((.......))...)..))))))......).))..((((((.....(.((....)))..((.(((.(((............(.((((((....(((....(((..(.(((....((((.(.....).))))..))).)..)))..)).)....))))))...(((((((((........)))))))))....)...))).)))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.((((.......(..........(((...((((((((.....{...(((.(((...((.........))...))).....(...((......)).).))).....))))))))..)))..........]]].).....)))))))))...)))))))...(((.(((..........]...]]........................(((..))).......................)))))).......)))))).(.(.((((((.((......(((..((((....)))).)))...)))))))).)..).....))))))((.....((.....((((((.......)))))).(.(.....((((..((...((((((...((.....)).))))))....[[(((.((...((....(((....)))..........((.((((((.((...)).))))))))......))....))...(((((........)))))]]((((....(((.....((.((((....)))).))..(.((....))....(...((((((...(.((((((((((((((((((((....{{...)))))....(.....((((.((((.....(((.....))).....))))))))......).....((((((((....).))))))))))).).)))))))))).)(...)....))))))...))............))).)))).)))..))......(......)..)))).((((.....))))..).)....((((.....(((((.(.((..(....(.......(((((....(.[..).....)))))((.((((..(((((...((((((.))))))........)))))....)))).))(...).......(((((((((.>.((.........))...(.(((((....((((.....))))......))))).).]...(.(((..((((((.(...........(((....))).........)))))..)))))..(((.........)))..........((............((.........))....)..)....)......)).))))))).)..))).).)))))..))))))....)).{..(((((.....]}.)))))....(((((..(...((.......(((.((((((..(((((...(((((...(((((.((((..)))).)))))...(.........((((.....((((((....))))))................(((((((((((.....)))))))))))..))))......)......)))))....)))))..(((.......)).)((((((...........))))))(......(((((...(.((((((.......))))))...)......[[.........)))).)(.(((..((((....{..))))..))))(((....)))....]].......((.(((...((..]]]]]].)).))).))....)}....))))..)))))........((.(.(.((((((...((.......))...))))))...)).).)........((...((((((......((((.......).))).......(((.(.....).))).....)))))..).....).).....(((.(((....)))..)))..a.))....).))))).....(((.(..(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}..)))))..)).))...))))...)))).((((...((((.....}.......))))...))))..)))...).)..)))......(((((......(((.....((..........((((..((((())))).)))).........))........((((....((((.(((((((......)))))))))))...))))..................))).....))))).(((((.(..(.......)..)....((.(((.(((.((......(((.(..(((((......)))))..)))).....))....)))..))).))..))))).. Structure of the idle mammalian ribosome-Sec61 complex; 28S ribosomal RNA 3j7q 7 120 3.4 RF00001 URS000002B0D5_9823 24930395 0003735 0005840 9823 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. ((((((.......((((((((.....((((((...(....)...))))..))....)))))).))(((.((......((.((..((....)).)).)).....)).)))...)))))).. Structure of the idle mammalian ribosome-Sec61 complex; 5S ribosomal RNA 3j7q 8 156 3.4 RF00002 URS00004B2C76_9823 24930395 0003735 0005840 9823 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<.<<.....>>>.......<<<......>>.............>>>......>>>....<<<..>>><<<<<<<<.......>>>>>>>>.................... .........................................(.((((.[[.....))).......(((......]].............)))......).)....((....))((((.(((.......))).)))).................... Structure of the idle mammalian ribosome-Sec61 complex; 5.8S ribosomal RNA 3j7r 5 3720 3.9 RF02540,RF02543 URS000080DD6F_9823 24930395 0003735 0005840 9823 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcggcccggcggaucuuucccgcgcgggggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucggccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcgcucuccccccucccggcgccgccggggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccgggggaggggccacgcgcgcgucccccgaagagggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcacacgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcgugagccgggcguggaauggagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagcggcgggggcggcgcgcgcgcgcgcccgcccccggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcugggucggucgucggccggcgccuagcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacaugagagguguagaauaagugggaggcccgggccgccggugaaauaccacuacucugaucguuuuuucacugacccggugaggcgggggggcgagccccgaggggcucucgcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccggucccccgcgggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcacgccguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu ..........................<<<<<.....<......>......>>>>>...........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<<...<<<<<<<<<<<...>>>>>>>.>>>>.....>>>>>..<<<<<<<<<....<<<<<<<<........<<<<<<<.....<<<<......>>>>.....((......<<<.....))>>>.....>>>>>>>...>>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..(((((.>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<.......<<<<<<<.<<<.....<<<<<<<<<<<...<<<....<<<<<.<<....<<<<.<<<..<<<<<>>>>>>>>>>>>>>>>.>>>......>>>.>>>>>>>>>>>......>>>.>>>.>>>>...<<<<<<<..<<<<<<<<<..<<<....<...<<.<<<.<<<<...<<.<<<<<..>>>>>>.>....>>>>.>>>>>.........>.>>>....>>>>>>>>>.....................<<<<..<<<<<<...<<<<<.>>>>>.>>>>>>....<<<.<<<<.<<<<<<<<<<<<<<<<<<<<<<<<.<<<<....>>>>.>>>>>>>>>>>.>>>>>>>>>>.>>>...>.>>>...>>>........<<<<<<<<.....>>>>>>>>........>>>>........>>.>>>>>....>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<<....>>>>>>>>..<<<<<...<<<..<<<...(((..[[.>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<......<<<....>>>..<<.<<<<<<<............<<<<<<<<<...<<<....<<<....<<<..<.<<<<.<.....>.>>>>>.>>>....>>>..>.>>...>>>>>>>...<<<<<<<<<........>>>>>>>>>...>>...>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<..<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>.>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<..........]]..))).......................<<<..>>>.......................>>>>>>>>>....>>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<<<<<...>>>>>>>>>>>......>>....>>...<<<<<........>>>>>))<<<<....<<<<...<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<<<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>.>.>>>>>>>>>>>>.........>>>>>>>..>............>>>>.>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>.>>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<.<<<<<.<<<<<...<<<<<<.>>>>>>........>>>>>...>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<......<.....<<<<....>>>>.....>...>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<..<<<<<<<<<.<<<<<<<<<<<<.<<<<..........<<<<<...<<<..>>>.............>>>>>.>>>>.>>.>>>>>>>>>>...<<<<<.....<<<<..<<.<<<<<<....>>>>>>>>..............<<<<<<<<<<<.....>>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>...>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<....<<<<<<.......>>>>>>.....<<.[.(((>>.....>>>>>>...<<<..<<<<.......>>>>..>>>.<<<....>>>.>>)))].....<<<<<<<..<<<...))))).>>>>>>>>>>.........>>>>..>>>>>>.......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<...<<<.<<<<<<.]]]..>>>>..>>.>>>..>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.....<<<<<<<.<<..<<<.....<<.........<<<<<..<<<<..>>>>.>>>>>........>>....<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>..............>>>..>>>>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<....<<<<<......>>>>>...>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(.(((......(...[..).......)))..).........((....))...((((......((.]...)).....))))...((((...((...((((.(((((((...)))))))..)))....).))....((((...((....((((((((........(((((((...({((((......)))))....[[(...).(((....}]]))).....)))))))...))))))))...))...))).).)....((((.((........)).)))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.......(((((((.((......(((((((((((...(((....(((((.((....((((.(((..((((()))))))))))))))).)))......))).))))))))))).......)).))).))))...((((((((.((((.(((((.(((....(...(.((((.((((.........((()))..........)))).))))).........).)))...))))).))))....................(((((..((((((...(((((.))))).))))))..((....((((.((((((((((((((((((((((((.((((....)))).)))))))))).))))))))))).)))...).))).....)..).....((((((((.....))))))))........)))))......))).)))))....)))...)))))))).[((((........))))((((((....((((((((.((((..(((...((((........)))).....)))...(......)...((((((((....))))))))..(((((...(((..(((....[[...[.)))..)))....))))).(((((.(((..(((......))).))).))).))....)))).))))))))..((.(...((((((.....(((((..((..((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))....))..))))).(.((.......))...)..))))))......).))..((((((.....(.((....)))..((.(((.(((............(.((((((....(((....(((..(.(((....((((.(.....).))))..))).)..)))..)).)....))))))...(((((((((........)))))))))....)...))).)))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.((((.......(..........(((..(((((((((.....{...(((.(((...((.........))...))).....(...((......)).).))).....))))))))).)))..........]]].).....)))))))))...)))))))...(((.(((..........]...]]........................(((..))).......................)))))).......)))))).(.(.((((((.((......(((..((((....)))).)))...)))))))).)..).....))))))((.....((.....((((((.......)))))).(.(.....((((..((...((((((...((.....)).))))))....[[(((.((...((....(((....)))..........((.((((((.((...)).))))))))......))....))...(((((........)))))]]((((....(((.....((.((((....)))).))..(.((....))....(...((((((...(.((((((((((((((((((((....{{...)))))....(.....((((.((((.....(((.....))).....))))))))......).....((((((((....).))))))))))).).)))))))))).)(...)....))))))...))............))).)))).)))..))......(......)..)))).((((.....))))..).)....((((.....(((((.(.((..(....(.......(((((....(.[..).....)))))((.((((..(((((...((((((.))))))........)))))....)))).))(...).......(((((((((.>.((.........))...(.(((((....((((.....))))......))))).).]...(.(((..((((((.(...........(((....))).........)))))..)))))..(((.........)))..........((............((.........))....)..)....)......)).))))))).)..))).).)))))..))))))....)).{..(((((.....]}.)))))....(((((..(...((.......(((.((((((..(((((...(((((...((.((.((((((.((((..........(((((...(((()))).............))))).)))).)).))))))..))...(..................((((((....))))))................(((((((((((.....)))))))))))............)......)))))....)))))..(((.......)).)((((((...........))))))(......(((((...(.((((((.......))))))...)......[[.........)))).)(.(((..((((....{..))))..))))(((....)))....]].......((((((...((..]]]]]].)).))))))....)}....))))..)))))........((.(.(.((((((...((.......))...))))))...)).).)........((...((((((......((((.......).))).......(((.(.....).))).....)))))..).....).).....(((.(((....)))..)))..a.))....).))))).....(((.(..(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}..)))))..)).))...))))...)))).((((...((((.....}.......))))...))))..)))...).)..)))......(((((......(((.....((..........((((..((((())))).)))).........))........((((....((((.(((((((......)))))))))))...))))..................))).....))))).(((((.(..(.......)..)....((.(((.(((.((......(((.(..(((((......)))))..)))).....))....)))..))).))..))))).. Structure of the translating mammalian ribosome-Sec61 complex; 28S ribosomal RNA 3j7r 7 120 3.9 RF00001 URS000002B0D5_9823 24930395 0003735 0005840 9823 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. ((((((.......((((((((.....((((((...(....)...))))..))....)))))).))(((.((......((.((..((....)).)).)).....)).)))...)))))).. Structure of the translating mammalian ribosome-Sec61 complex; 5S ribosomal RNA 3j7r 8 156 3.9 RF00002 URS00004B2C76_9823 24930395 0003735 0005840 9823 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<.<<.....>>>.......<<<......>>.............>>>......>>>....<<<..>>><<<<<<<<.......>>>>>>>>.................... .........................................(.((((.[[.....))).......(((......]].............)))......).)....((....))((((.(((.......))).)))).................... Structure of the translating mammalian ribosome-Sec61 complex; 5.8S ribosomal RNA 3j7r S2 1742 3.9 RF01960,RF01959,RF00177 URS000080E1CB_9823 24930395 0003735 0005840 9823 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucgcuccucucccacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgccccccguggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuccgcgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcgggcguccccgccgccucucggccggggcccgaagcauuuacuuugaaaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggucggcccacggcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<...<<<..........>>>..>>.>>......<<........<<<.<....<<....<<<<<..................<<.....<<.............>>......>>.........<<<<...<<<<<<....>>>>>>...>>>>....<<<<<...<......>..>>>>>...........<<<<.<<<<......>>>>>>>>.>>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>...<<....>>.....>>>>>>.........<<<....<<<.....>>>..>>>..>...>>.>.....<<<<<<.<..<<<....>>>..>..>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.........)).........>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<.....<<.<.<<....>>.>.>><<.<..<...........>>.>>..<<<<<<.<.......<<...<.......>.<<<<.......>>>>...>>......>.>>>..>>>.......<<....<<<<<<<...............>>>>>>>...>>....>>....<<<<<<..<...<<<<..<<<.<<<<<<<<...<<<......>>>......>>>>>>>>.>>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<....<...<<<<.<.....>.>>>>...>.>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<........<<........>>..........<<<<<......<<<<<........<...<<........>>...>......>>>>>...<<.<<<....<<<<<<<....<<<.<<<<......>>....<<......>>....>>.>>>....<<<...<...<<<<..<<<.....<<<...<<<....>>>..>>>.....>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>...>...>>>>>.......>>>>>......>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>.........<..<<<<<..........>>>>>.>.........>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<.<<<<<<<<<<<<.....>>>>>>>>>>>>...>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))(((.....((...(.((..((.....(((..((..((....((....((..........))...))[))......(((.......(((.(.(..((....(((((..................((.....((.(.(.....).).))......))..........(((...((((((....))))))...)))....(.((((.............)))))...........((((..(((......))).)))).)).)))...))).).))).(((....(((....((((((...........)))))))))......)))...(((.(.(.......))....)))))).((.(((..........))).))...((....)).....)).))).).....(.(((...(((..]....)).))))).)...)).).....((.((..(..(((....)))..)...))..))......((..(...........)..))..........(((([[......((((.....((..]])).......)))).))).)..)).....)))..[......(.([[...(.(.((...(((..(......(.(.((....)).).).((...................))..(((((..(.......((..(.........).(((.......)))....))......)..))..)))..........(..(.((.((...............)).)).).).......)....(((..(...(...((((..(((.((((((((...((........))......)))))))).)))..................))))..)...)...))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((....(((....((((((...............))))))....)))...((..]]))........].))))).).(((......((((....))))....)))...]]].](((.(.((((.((..((...((((..(((.((((((......((........))..........(((((......((((..........(...............).........))))...((.(((...(.((((((....(((.((.((....))......(......).....)).)))....(((...(...((((..(((.....(((...(((....)))..))).....)))..))))..)..(..(((((.....)))))....)...)))....))).))).....).))))).......)))))...)).)))).))).(...(...((........(.......(((.((((....)))).)))....).........))...)......(.....(((((..........))))).....)..)..))).).....((((((.(.......).))))))......))...)).))))).).))..(.(..((.(..((((.((..(.(((((((..(((..((((.((...((.((.(((((((((.((.....)).)))))))))...)).))...)).))))..)))..))))))))..)).))))...).))...)..)..(.(((((((....)))))))).}........ Structure of the translating mammalian ribosome-Sec61 complex; 18S ribosomal RNA 3j7r S4 10 3.9 24930395 9823 uuuuuuuuua .......... .......... Structure of the translating mammalian ribosome-Sec61 complex; Messenger RNA 3j7r S5 74 3.9 RF00005 URS000080E2D5_9823 24930395 0030533 0006412 9823 gcccggauagcucaggguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca .<<<<<<.................<<<<<<.....>>>>>>......<<<<.......>>>>.>>>>>>..... ..((.(..........[........(((((.....))))).......(.(...].....).)...)))...... Structure of the translating mammalian ribosome-Sec61 complex; A/P tRNA 3j7r S6 76 3.9 RF00005 URS000080DE53_9823 24930395 0030533 0006412 9823 ugcccgguagccccgaagguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca ....<<<..<<............>>.<<<<<<.....>>>>>>......<<<.........>.>>.>>>....... .(.((((....(.(.......).)..((((.........)))).....(.(.(.(..)..)..)).)))).).... Structure of the translating mammalian ribosome-Sec61 complex; P/E tRNA 3j7z A 2854 3.9 RF02540,RF02541 URS000080E25C_83333 25306253 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauggaaguguggacgccagucugcauggcuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<.....>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>.>......>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.......................................>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<.<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>..>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((((((.)))).))...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..((((......))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((((.(.............................................).))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....((.((((....))).).))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Structure of the E. coli 50S subunit with ErmCL nascent chain; 23S rRNA 3j7z B 118 3.9 RF00001 URS0000366A67_83333 25306253 0003735 0005840 83333 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))). Structure of the E. coli 50S subunit with ErmCL nascent chain; 5S rRNA 3j81 2 1780 4.0 RF01960,RF01959,RF00177 URS000080E249_28985 25417110 0003735 0005840 28985 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacauggauaucugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacuccuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaacuggagggcaagucuggugccagcagccgcgguaauuccagcuccaguagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggucugguuguccggucgguuuuucaaccggaucuuuccuucuggcuaaccuguacuccuugugggugcaggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcgaaagcucgaauauauuagcauggaauaauggaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuucuuaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaggguugcuggcacuugccgguugacucuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgaguacaaccuuggccgagaggucuggguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggauuugcuuagagaagggggcaacuccaucucagagcgaagaaucuggucaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<...[[[[>>>>>[[[..((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[..................<.<..<<.<<.......>>.>>.....>>.........<<<<<..<<....>>..>>>>>[...((((((......<<<<<<<<<<<....>>>..............)))))).....]...<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>..>..]]]]]].........<<<....<<<.....>>>..>>>...............<<.<<<<<<............>>>>>>..>.>.....<<.................>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..)))))).]]].........[[[{{.......{{...[[[.[[.....<<<<<<<<<<.....<<>>.....>>>>>>>>>.>....<<<<<<....<.<.<..<.......>..>.>.>....>>>>>>...<<<<<.<<.......<<...<.......>..<<.......>>...>>......>>.>>..>>>.........[[...((((((((....>>>>>>>>.))))))))..]].....]]....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<.<.......>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<.....<..<<..<<........>.>.>>.>....>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<......>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<<<<<<<<....>>>>>>.>>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<<.<<<<....>>>.>>>>....>>.......>>>>>>>......<....<<<<<<..........>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<.<<<.<.<<<..<<<<..<...<<<<<....<..................>....>>>>>...>..>>>>..>>>.>.>>>.>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))((((.((((((...(.....((.....(((..((..((....((.....(..........)....)).))......(((.......(((..((..((....(((..................(.....(.(.(......)).).......).........(((((..((....))..)))))(.(.((((((......[[[[[[[[(((....))).....(......).)))))).)...).(.((....((((..).)))...)))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)).))).).....(.(((...((((.....))).))))).)......).....((....(.(..((....))..).).....))......(.(.(...........))..).........(((..[[....(.((((.....((..]])).......)))))..)))..))))))))))..{......((({....(.(.((...(((.((....(.(((.(((((.....(()).....))))).)).))....((((((.........(...........).........))))))...(((((.((.......((..((.......)).(.(....)..)...))......)).))..))).........(....(.(.((((....]]]]]]]].))).)).)...).....))....((..((.((...(((...((..((((((.....((........))........))))))..)).......((....))....)))..).)))...))...)))...)).)....(((((.........((((.........))))......)))))......<...(((.((.(((..(((.((((.(.((.......))))))).)))..)))...((...}))...))...}.))))))).(((......((.(....).))....)))...]]].](((((.(((((((..((..(((((..(((.(((.((......((........))..........(((((.(....(((((........(..(............)..)......)))))....(.((....(.((((((....(((.(.(((....)))..(.((......)))....).)))....(((((.((..((((..((((((.(((((....)))))..))))))..)))).))..(.(((.(........))))....)..)))))....))).))).....)..)))......).)))))...))..))).))).(...(((((((......((.....((..((((....)).)).))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((.....(..(....(((..((((..(...((.(((..(....................)..))).))...)..))))..)))....)..)....)).))))...).))...)..)..(((((((((....)))))))))>........ CryoEM structure of a partial yeast 48S preinitiation complex; 18S rRNA 3j81 1 74 4.0 RF00005 URS000080E1DE_28985 25417110 0030533 0006412 28985 gcgccguggcgcaguggaagcgcgcaggucucauaaaccugauguccucggaucgaaaccgagcggcgcuacca <<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((.......)))).(((((.......))))).....(((((.......)))))))))))..... CryoEM structure of a partial yeast 48S preinitiation complex; Met-tRNAi 3j81 3 22 4.0 25417110 32630 aucucucucuaugcucucucuc ...................... ...................... CryoEM structure of a partial yeast 48S preinitiation complex; mRNA 3j8g A 115 5.0 RF00001 URS000080DF7E_83333 25389271 0003735 0005840 83333 gcugcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggc .<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.....<.<<<<<<<<...>>>>>>>>...>...>>...>>>>.>>.. .((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))).)).. Electron cryo-microscopy structure of EngA bound with the 50S ribosomal subunit; 5S rRNA 3j8g B 2874 5.0 RF02540,RF02541 URS000080E25C_83333 25389271 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu 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((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...(((..((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))........((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).......((((..(((((......)))))..))))...(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((...(((((((((.....(((...(((.((((...((...((.....))....))...)))).)))..)).).....)))))).)))...))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.......(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((..((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....((((..(((..(((((((((((....{{{...))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((...(..(((((((..(((..........))))))))..)))..(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)..[..(((((......].)))))..((((((((.(((.((.......(((.((((((..(((((.(((.(((((.(((((((((((.(..(.(.....................................................................))..).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).(.][.[[[.)....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))).......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.((((((...))))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Electron cryo-microscopy structure of EngA bound with the 50S ribosomal subunit; 23S rRNA 3j92 2 75 3.6 RF00005 URS000041AF00_9823 25578875 0030533 0006412 9823 cgcgggguggagcagcgguagcucgucgggcucauaacccgaaggucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((....[..)))).(((((.......))))).....(((((..]....)))))))))))..... Structure and assembly pathway of the ribosome quality control complex; tRNA 3j92 5 3662 3.6 RF02540,RF02543 URS000080DE35_9986 25578875 0003735 0005840 9986 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcggcccggcggaucuuucccgcgcgggggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucggccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcgcucuccccccucccggcgccgccggggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccgggggaggggccacgcgcgcgucccccgaagagggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcacacgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcgugagccgggcguggaauggagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagcggcgggggcggcgcgcgcgcgcgcccgcccccggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcugggucggucgucggccggcgccuagcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacauguuuuuucacugacccggugaggcgggggggcgagccccgaggggcucucgcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccggucccccgcgggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcacgccguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<<...<<<<<<<<<<<...>>>>>>>.>>>>.....>>>>>..<<<<<<<<<....<<<<<<<<........<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>...>>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<......<<<<<<<<.<<<.....<<<<<<<<<<<...<<<....<<<<<.<<....<<<<.<<<..<<<<<>>>>>>>>>>>>>>>>.>>>......>>>.>>>>>>>>>>>......>>>.>>>.>>>>>..<<<<<<<..<<<<<<<<<..<<<....<...<<.<<<.<<<<...<..<<<<<..>>>>>..>....>>>>.>>>>>.........>.>>>....>>>>>>>>>....................<<<<<..<<<<<<...<<<<<.>>>>>.>>>>>>....<<<.<<<<.<<<<<<<<<<<<<<<<<<<<<<<<.<<<<....>>>>.>>>>>>>>>>.>>>>>>>>>>>.>>>....>>>>...>>>........<<<<<<<<.....>>>>>>>>........>>>>>.......>>.>>>>>....>>>...>>>>>>>>..<<<<........>>>><<<<<<...<<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<<....>>>>>>>>..<<<<<...<<<..<<<...(((..[..>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>>.<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<......<<<....>>>..<<.<<<<<<<............<<<<<<<<<...<<<....<<<..<.<<<..<.<<.<.<.....>.>.>>>.>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<........>>>>>>>>>...>>...>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<........<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>....>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<...........]..))).......................<<<..>>>.......................>>>>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<<<<<...>>>>>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<....<<<<<<<....>>>>>>>...<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>............>>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<...............>>>>><<.<<<<<<<<<<<...<<<<<<.>>>>>>........>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<......<.....<<<<....>>>>.....>...>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<..<<<<<<<<<.<<<<<<<<<<..>>>>>>>>>>...<<<<<.....<<<<..<<.<<<<<<....>>>>>>>>..............<<<<<<<<<<<.....>>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>...>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>><<<<....>>>>>>)))].....<<<<<<<..<<<..)))))).>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<]]].>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.....<<<<<<<.<<..<<<.....<<.........<<<<<..<<<<..>>>>.>>>>>........>>....<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>..............>>>..>>>>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<....<<<<<......>>>>>...>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..(((((((((((.....)))))).))))....))))....(((((..((....((((((((.(......((((((((..({((((......)))))....[[(...).(((....}]])))...).)))))))..)))))))))...))..)))))..)....((((.((........))).))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((......((((((((.(((.....(((((((((((...(((.(..(((((.((....((((.(((..((((()))))))))))))))).)))..)...))).))))))))))).....).)).))).)))))..((((((((.((((.(((((.(((....(...(.((((.((((......(((((()))))).......)))).))))).........).)))...))))).))))....................(((((..(((((((..(((((.))))))))))))..((.((.((((..(((((((((((((((((((((((.((((....)))).)))))))))).))))))))))).))....).)))...)))..).....((((((((.....))))))))........)))))......))).)))))....)))...)))))))).[((((........))))((((((....(((((((((((((..(((..(((((........)))).)...)))...((....))...((((((((....))))))))..(((((...(((..(((...[[[...[.)))..)))....))))).(((((((((.((((......))))))))))).))....)))))))))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)<)))...(((..((.((.......B)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....((.((....))).)((.(((((((............(.((((((....(((....(((..(.(((....((((.(.....).))))..))).)..)))..)).)....))))))...(((((((((........)))))))))....)...)))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((A((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((..........]...]]].......................(((..))).......................)))))))))....)))))).((((((((((.((......((((.((((....))))))))...)))))))))).)).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...((..(.(((....))).....)....((.(((((((((...)))))))))))......))....))...(((((........)))))]]((((....(((.....(((((((....)))))))..((((....)))...(...((((((...((((((((((((((((((((((....{{..).))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...))............))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((...((((((.))))))........)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(...(......(((.....).))......).)))))..)))))..(((.........)))..........((.(......).(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.(((((((((.((((((((((..))))))))))...(((((.....((((..(..((((((....)))))).)..............(((((((((((.....)))))))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(.((((.......).)))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..b.))..))).))))).....(((((..(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}..)))))..)).))...))))...)))).((((...((((...a.}.......))))...))))..)))...).).))))......(((((......(((.....((..........((((..((((())))).)))).........))....((..((((....((((.(((((((......)))))))))))...))))..))..............))).....))))).(.(((.(..(.......)..)....((.(((((((.((.....((((.(..(((((......)))))..)))))....))....)))).))).))..))))... Structure and assembly pathway of the ribosome quality control complex; 28S rRNA 3j92 7 120 3.6 RF00001 URS000002B0D5_9986 25578875 0003735 0005840 9986 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. Structure and assembly pathway of the ribosome quality control complex; 5S rRNA 3j92 8 156 3.6 RF00002 URS00004B2C76_9986 25578875 0003735 0005840 9986 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<.<<.....>>>.....(.<<<......>>.............>>>..)...>>>....<<<..>>><<<<<<<<.......>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))((((((((.......)))))))).................... Structure and assembly pathway of the ribosome quality control complex; 5.8S rRNA 3j9m A 1472 3.5 RF02541,RF02540 URS000080E357_9606 25838379 0003735 0005840 9606 gcuaaaccuagccccaaacccacuccaccuuacuaccagcaaccuuagccaaaccauuuacauaaaguauaggcgauagaaauuguggcgcaauagauauaguaccgcaagggaaagaugaaaaauuauaaccaagcauaauauagcaaggacuaaccccuauaccuucugcauaaugaauuaacuagaaauaacuuugcaaggagagccaaagcuaagacccccgaaaccagacgagcuaccuaagaacagcuaagagcacacccgucuauguagcaaaauagugggaagauuuauagguagaggcgacaaaccuaccgagccuggugauagcugguuguccaagauagaaucuuaguucaacuuuaaauuugcccacagaaccaaauccccuuguaaauuuaacuguuaguccaaagaggaacagcucuuuggacacuaggaaaaaaccuuguagagagaguaaaaaauuuaacacccauaguaggccuaaaagcagccaccaauuaagaaagcguucaagcucaacaccaaaaaucccaaacauauaacugaacuccucacacccaauuggaccaaucuaucacccuauagaagaacuaauguuaguauaaguaacaugaaaacauucuccuccgcauaagccugcgucagaucacacugacaauuaacagcccaauaucuacaaucaaccaacaagucauuauuacccucacugucaacccaacacaggcaugcucauaaggaaagguuaaaaaaaguaaaaggaacucggcaaaucuuaccccgccuguuuaccaaaaacaucaccucuagcaucaccaguauuagaggcaccgccugcccagugacacauguuuaacggccgcgguuaaccgugcaaagguagcauaaucacuuguuccuuaaauagggaccuguaugaauggcuccacgaggguucagcugucucuuacuuuuaaccagugaaauugaccugcccgugaagaggcgggcauaacacagcaagacgagaagacccuauggagcuuuaauuuauuaaugcaaacaguaaccugcauuaaaaauuucgguuggggcgaccucggagcagaacccaaccuccgagcaguacaugcuaagacuucaccagucaaagcgaaccucaauugauccaauaacuugaccaacggaacaaguuacccuagggauaacagcgcaauccuauucuagaguccauaucaacaauaggguuuacgaccucgauguuggaucaggacaucccgauggugcagccgcuauuaaagguucguuuguucaacgauuaaaguccuacgugaucugaguucagaccggaguaauccaggucgguuucuaucuacuuuauuccucccuguacgaaaggacaagagaaauaaggccuacuucacaaagcgccuucccccguaaaugauaucaucucaacuuagauacccacacccaagaacaggguu <<<.......<<<<....................................<......>.....<.....<<.....>>....>...>>.>>.............<<....>>......................>>>...........<<<.......>>>...<.<........>.>.<<<<<<.........<<<.<<..<<....>>...>>.>>>...<<.<..<<<<<.<.....<<<<<.<<<..<<<...>>>...<<<..<<<<........>>>>.>>>....>>>.>>>>>...<<.......>>......>.>>>>>.....>.>>..<<<<<<....<<<<....>>>><<<.<<<<<<<<<<.....<<......>>.....>>>>>>>>>>..>>>.<<<<<<<<<<......>>>>>>>>>>...<<<......>>>....<<<.<<<...<..............<.....<<.........>>.....>.......<<<......>>>...........................>...>>>>>>........>>>>>>...<<<<<......>>>>>.........>>>>>>.......<<..<<<....>>><<<<..<<<<........<<<<<......>>>>>......<<<...<<<<.......................>>>>.......>>>.....<<......>>.>>>>.....>>>>..<<<<...<<<<<<<..<<.........<......<<<<<<..<<<.........>>>...<<<<<<.............>>>>>>....<<<.<<<..<<<<<....>>>..>>>>><<<<<....>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>....>>.>>>>.....>..>>..>>>>>>>>>>>.>>...........<<<<<........>>>>>.......<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<..........>>>>>>>>>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<.....<<<..<<<<.....>>>>..>>>....>>.........<<<....>>>............>>>>..>>>>>>.......<<<..<.<<<<<<...<<.......>>...>>>>>>...>.>>.>.......<<<<<.<<<<<<..<<.<<<<<<......>>>>>>...>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>..<<<.<<<.................>>>.>>><<<<<...<<<....>>>.>>>>>......<<<................>>>.........<<<<.......>>>>. ((.....(..((((....................................(...[..).....(.....((.]...))....)...)).)).............((....))....).....(...)........)).........(.(((.......))).[.(.(........).).((((.(.........((..((..((....))...)).).)...((.(...((((.(.....(((((.((((.(((..[)))...(((..((((.......{)))).)))..).))).))))).(.((.......))...)..).))))......).))..((((((....((.(....)).).((.((((((((((.....((......)).....))))))))))..))..((((((((((......))))))))))...(((......)))....(((.(((...(..............(.(..(((.........)))..).)....(..(((......))))..........................)...))))))........))))))...(((((......))))).........)).)))(......((..(((....)))(((...((((......(.(((((......)))))......(((...((((...............(..)....)))).......))).)...((......)).))))......)))..((((....((((((..((..(....(........((((((.].((.........))....((((((.............))))))....(((.(((..(((((....)))..)))))(((((....)))))........((..........(((((.......)))))..)..)....)))....)).))))....)..))).).))))).)))).)).....)).{..(((((.....]}.))))).......((..(((.((......((((.(((((...(((((.(((.((((..........))))).)))))))..(((......[)))((((((..........]))))))(.((.....((...(((....[..)))...))....)).........(((....))).....)]......)))..))))))......((((..(.((((((.(.((.......)))..))))))...).)).).)......((((.((((((..((.((((((......))))))...)).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..}.))..))).))..(((.(((......(....).....))).)))(((((...(((....))).)))))......(((................))).........((((.......)))). Structure of the human mitochondrial ribosome (class 1); 16S rRNA 3j9m AA 923 3.5 RF00177 URS000044DFF6_9606 25838379 0003735 0005840 9606 auagguuugguccuagccuuucuauuagcucuuaguaagauuacacaugcaagcauccccguuccagugaguucacccucuaaaucgaucaaaaggaacaagcaucaagcacgcagcaaugcagcucaaaacgcuuagccuagccacacccccacgggaaacagcagugauuaaccuuuagcaauaaacgaaaguuuaacuaagcuauacuaaccccaggguuggucaauuucgugccagccaccgcggucacacgauuaacccaagucaauagaccggcguaaagaguguuuuagaucacaauaaagcuaaaacucaccugaguuguaaaaaacuccaguugacacaaaauagacuacgaaaguggcuuuaacauaucugaacacacaauagcuaagacccaaacugggauuagauaccccacuaugcuuagcccuaaaccucaacaguucaacaaaacugcucgccagaacacuacgagccacagcuuaaaacucaaaggaccuggcggugcuucauaucccucuagaggagccuguucuguaaucgauaaaccccgaucaaccucaccaccucuugcucagccuauauaccgccaucuucagcaaacccugaugaaggcuacaaaguaagcgcaaguacccacguaaagacguuaggucaagguguagcccaugagguggcaagaaaugggcuacauuuucuaccccagaaacgauagcccuuaugaaauaagggucgaagguggauuuagcaguaaacuaagaguagagugcuuaguugaacagggcccugaagcgcguacacaccgcccgucacccuccucaaguauacuucaaaggacuuaacuaaaaccccuacgcauuuauauagaggagacgucguaacaugguaaguguacuggaaagugcacuuggacgaac ..((((..<<<<<<.)))).<<<<<<.<<..<<<<<<<<..<.<<<.<<<..<......>......<<..<.....<<<.<..<<..>>.>..>>>...<<<<....<<...<<<....>>>..>>......>>>>.<<...>>>>>.<<<....>>>.....>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>.....<<<<<<<<.....(((.....((.>>>)).......)))..>>>>>..>>.>>>>>>..<<<((.....<<<<..<<<<......<<<<<<......<<<.<<<.<<<......>>>..>>>.>>>.............<<....>>.>>>>>>.....>>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<.<<<<<..))..>>>>>.>.>>>.<<.......<<<<....>>>>.....>>..>>>>>><<<<<.<<<<<<<...<<<.<<<<<..<<<<<<<<<<.....<<........>>..........<<<<<<<.......<<.<<<..<<<<<<.<.....<<..<<<<<.....>>>.......>>..>>.....<<<....>>>.....>...>>>...>>>>>>>>....>>>>>>>..>>.>>>>>>>>.....<<<<.....>>>>.<....<<<<<<<<...>>>>>>>>....>.....>>>>>.....<<<<<<<.........>>>>>>>.....>>>...>>>>>>>>>>.>>....<..<<.<...<<<<<<..<<<<<......<<<..<<.....>>...>>>.......>>>>>.>>>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>........ [.[[[[..(((((..]]]]]((((((.((..((((((((..(.(((.(((..(......)......(((.......(((.(..((())).)..)))...((((....((..((((....))).)))......)))).((...))))).(((....))).....)))))))......(.(((...(((((....)))).))))).)).)))))).....((((([[[.....(((.....((.]]])).......)))..)))))..)).))))))..((([[...(.((((...(((......(((((((.....(((.(((.((........))..))).))).....).....(.((....))))))))).....)))....))))....((((((...((...((((.........))))...))))))))......{...(.(((((..]]..))))).))))).((.......((((....)))).....))...)))))(((((.(((((((...(((.(((((..((((((((((.....((........))..........(((((((.......((.(((...((((((.(....((..(((((.....))).......))..)).....(((....))).....).).)))...)).)))))....)))))))..)).)))))))).(...((((.....)))).(....(((((((.....)))))))....)..)..))))).....(((((((.........))))))).....)))...)))))))))).))..(.(..((.(...((((((...((((..((..(.(..((.....))...).)..).)..))))..))))))..).))...)..)..(((((((((....)))))))))}....... Structure of the human mitochondrial ribosome (class 1); 12S rRNA 3j9w AA 1544 3.9 RF00177,RF01959,RF01960 URS0000462957_224308 25903689 0003735 0005840 224308 ggagaguuugauccuggcucaggacgaacgcuggcggcgugccuaauacaugcaagucgagcggacagaugggagcuugcucccugauguuagcggcggacgggugaguaacacguggguaaccugccuguaagacugggauaacuccgggaaaccggggcuaauaccggaugguuguuugaaccgcaugguucaaacauaaaagguggcuucggcuaccacuuacagauggacccgcggcgcauuagcuaguuggugagguaacggcucaccaaggcgacgaugcguagccgaccugagagggugaucggccacacugggacugagacacggcccagacuccuacgggaggcagcaguagggaaucuuccgcaauggacgaaagucugacggagcaacgccgcgugagugaugaagguuuucggaucguaaagcucuguuguuagggaagaacaagugccguucgaauagggcgguaccuugacgguaccuaaccagaaagccacggcuaacuacgugccagcagccgcgguaauacguagguggcaagcguuguccggaauuauugggcguaaagggcucgcaggcgguuucuuaagucugaugugaaagcccccggcucaaccggggagggucauuggaaacuggggaacuugagugcagaagaggagaguggaauuccacguguagcggugaaaugcguagagauguggaggaacaccaguggcgaaggcgacucucuggucuguaacugacgcugaggagcgaaagcguggggagcgaacaggauuagauacccugguaguccacgccguaaacgaugagugcuaaguguuaggggguuuccgccccuuagugcugcagcuaacgcauuaagcacuccgccuggggaguacggucgcaagacugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggucuugacauccucugacaauccuagagauaggacguccccuucgggggcagagugacagguggugcaugguugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuugaucuuaguugccagcauucaguugggcacucuaaggugacugccggugacaaaccggaggaagguggggaugacgucaaaucaucaugccccuuaugaccugggcuacacacgugcuacaauggacagaacaaagggcagcgaaaccgcgagguuaagccaaucccacaaaucuguucucaguucggaucgcagucugcaacucgacugcgugaagcuggaaucgcuaguaaucgcggaucagcaugccgcggugaauacguucccgggccuuguacacaccgcccgucacaccacgagaguuuguaacacccgaagucggugagguaaccuuuuaggagccagccgccgaaggugggacagaugauuggggugaagucguaacaagguagccguaucggaaggugcggcuggaucaccuccuu ...<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<<<...<<<<<....>>>>>...>>>>.>>>>>......<<........<<<<<<<..<<...<<<<<<<.<<<<.....<<<<<<....>>>>>>......>>>>.....<<<<<<<<<<....>>>>>>>>>>.....<<<<<<....>>>>>>.>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>..<<<<<<<<.......<<<<<<<<<<<.....>>>>>>>>>.>>.......>>>>>>...>>.<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<.......<<<<<<.....>>>>>>.....>>>>>>>..>>>>>>>>>...<<<.<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>..>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<<....>>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<........<<........>>..........<<<<<<<......<<<<<<<....<<<<<....>>>>>....<<<....>>>.>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<......>>>>>...>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>......>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>.....<<<<<<.........>>>>>>.......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<..<<<<....<.<<<<..<<<..<<<...>>>.>>>.>>>>.>...>>>>..>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............. ...((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((...(((((....)))))...)))).)))))......(((.......(((((((..((...(((((((.((((.....((((((....))))))......))))......(((((((((....)))))))))......((((((....)))))).)))))))..))))))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((((((((........((((((((((.....))))))))).)........))))))...)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))...).)))))))..)))))))))..((((.((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))))..)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((......))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((.(.....(((((....)))))....(((....)))..).)).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..((......))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((..((((....(.((((..(((..(((...))).))).)))).)...))))..))))))..))).))))..).))...)..)..(((((((((....)))))))))}............ Cryo-EM structure of the Bacillus subtilis MifM-stalled ribosome complex; 16S ribosomal RNA 3j9w AX 77 3.9 RF00005 URS00002C7A07_224308 25903689 0030533 0006412 224308 gguccgguaguucaguugguuagaaugccugccugucacgcaggaggucgcggguucgagucccguccggaccgcca <<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.........)))).(((((.......))))).....(((((.......)))))))))))).... Cryo-EM structure of the Bacillus subtilis MifM-stalled ribosome complex; tRNA-Asp 3j9w AY 19 3.9 25903689 224308 ugugaacgaugaggaagac ................... ................... Cryo-EM structure of the Bacillus subtilis MifM-stalled ribosome complex; mRNA 3j9w BA 2923 3.9 RF02540,RF02541,RF00002 URS000081169B_224308 25903689 0003735 0005840 224308 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<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<.....((.>>>.....<<<<<<<..<<<)).....>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<<<<<<<<.........>>>>>>>.>>.>>....<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<......<<.....>>.....>>>>...(((....<<<<<<<<<..>>>>>>>>>......<<<<<<<<<.....<<<<.......<<<<<<<<<<.<<<.....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>.>>>>>..>>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<......>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<.<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>......>>>>>.>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>...>.>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<...<<<<<<<<<.....<<<...<<<<<<<<...<<<<<<<.....>>>>>.>>...>>>>>>>>..>>.>.....>>>>.>>>>>..>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<.........>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<...>>>>>>>....>>>>>>..<<<<<<<.<<......<<<<<.<<....>>.>>>>>...>>.>>>>>>>........>>>>>><......<<....<<<<<<.......>>>>>><<<<....<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<.<<<<<<......<<...<<<<....<<<<..<<<..<<<.<.<<<.<.....{....>.>>>.<<...<<<<<.<<<<.<<<<<<<.<<.....>>>>>>>>>....>>>>..>>>>>...>><..<<...........>>...>>.>>>...>>>...>>>>.........>>>>..>>..>>>>>>>>>>>>>>>..>>.....<<......>>.>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<....<<..>>.....>>>>><<<<<....<<<<....>>>>...>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>..<<<<.<<<..<<<<<<<..<<<...<<...<<<<<..<<....>>...>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>...>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.(...<<<<<.......)>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<<.<<<.<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>.>>>....<<.<<<<<<.....>>>>>>>>.....>>>>>>>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.}..>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>. ((((((.......(((((((((.....(((..(((((((((((((......((((((.....[[[)))...].((((((...(((]].....)))......))))))...)))....(((....)))(((((((......))))))).(((((((((.........))))))).)).)).....(((((.....(...[..)......)))))...........((....))...((((......((.]...)).....))))...((((...((((((((....))))))))....{.(((((((((.....((((.......((((((((((.(((...(.((((......)))))[[(...).(((.....]])))...)))...)))))))))))))).)))))..)))))....((((((((..[......))))))))....}.(((((].[[[[)))))..)))......)).))))))).))...............((....))....)).........((((....)))).............).....)))))))))......(.((((..((((..[...))))..)))).<.(.(........).).((((((....(((((((.(((((..(((...(((.....)))...)))...((....))..((((.....))))......))))).)))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)<)))...(((.(((((.......A))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....((((......))))(((((((((...(((((((((.....(((...((((((((.(.(((((((.....))))).)))..))))))))..)).).....)))).)))))..))))))).))..(((((((.((......)).)))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((..(((.........)))..))).....(...((......)).).)))))...)))))))))).))...........]]].)...))))))))))...)))))))(((((((...)))))))....))))))(((((((...((......(((((.((....))])))))...))...))))).)).....))))))(......((....((((((.......))))))((((....(((...((.([((((((...((.....)).)))))))...[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((.((((((......((...((((....((((..(((..(((.(.(((.((....{..).).))).((...((((..((((.(((((((.((.....)))))))))....))))...))))...))(..((...........))...)).)))...)))...))))(..).....))))..))..))))))))))))))).])).....((......))..))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))(((((....((((....))))...)))))(...).......((((((.((.>.((.........))...(((((((.....(((....)))..[....))))))).}((((.(((..(((((((..(((...((...(((((..((....))...)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...))..)))))).)..))).)))))))).)))))).....)).[..(((((.....>].)))))..((((((((.(((.((......((((.((((((..(((((.(((((((((.(((.((((((((((((.(.........(((((..(((......((((((((....))))))))...)))............)))))).)))))))))))).)))....((.((((((...].)))))))).....)))))))))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))..a.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}..))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((....))))....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))...))))))). Cryo-EM structure of the Bacillus subtilis MifM-stalled ribosome complex; 23S ribosomal RNA 3j9w BB 112 3.9 RF00001 URS00001CC3E3_224308 25903689 0003735 0005840 224308 ugguggcgauagcgaagaggucacacccguucccauaccgaacacggaaguuaagcucuucagcgccgaugguagucggggguuucccccugugagaguaggacgccgccaa <<<<<<<....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<.......<<.<<<<<...>>>>>.>>.......>>..>>>>>>>. (((((((....((((((((.....((((((...(.....)...))))..))....)))))).)).((.......((.(((((...))))).)).......))..))))))). Cryo-EM structure of the Bacillus subtilis MifM-stalled ribosome complex; 5S ribosomal RNA 3j9y a 1539 3.9 RF00177,RF01959,RF01960 URS000080DDC0_562 25870267 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggaucaccuccu .......<<<<....((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<..<<<<<<<.<<....>>.>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<......>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..))))..<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>............ .......((((....[[[..)))).((((.(((((..((((((((.....(((.(((..(((..((.((..((((((...(....)...))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....(((((......)))))......)).).....(((....)))....((((((..(......))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).......(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((((.......)))))))).....)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]]..(((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((..(((((((....))))))).............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((.....((..(((.....)))))......)))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....))))))))..)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Cryo-EM structure of tetracycline resistance protein TetM bound to a translating E.coli ribosome; 16S ribosomal RNA 3j9y v 77 3.9 RF00005 URS00008116A7_562 25870267 0030533 0006412 562 cgcggggnggagcagccuggnagcucgucgggcucauaacccgaagaucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Cryo-EM structure of tetracycline resistance protein TetM bound to a translating E.coli ribosome; P-site fMet-tRNAfMet 3j9y A 2900 3.9 RF02540,RF02541 URS0000A76322_562 25870267 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccgggagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<....<.<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>..>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<<..>>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<..<<<<..>>>>...>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<.....<<.........>>.....>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<............>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<......>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<<.<<....>>..>>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>.............>>>>...>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...(((..((((......((((((((((.((.(((...(((((......)))))[[......(((.....]])))...)))...)).))))))))))...))))........((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((((..)))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(..(..(..)..)...)...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[.....((((((.....(.....((..(((((..(((.....{.(((((.(.......................).....(..(((......)))).)))))...)))..))))).))...........]]].)...)))))).)))...)))))))(((((............)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..(((((((((((....{{{...))))))((..((((....((((.((((((.((.....)))))))).)..)))...[))))...))(..(((........)))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((.(......).(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((((((((..(....(.........((.((............((((.(......).))))...................)).)))....)..))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))(.((...(((((((...(((((.........))))).....((.[.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Cryo-EM structure of tetracycline resistance protein TetM bound to a translating E.coli ribosome; 23S ribosomal RNA 3j9y B 120 3.9 RF00001 URS00008116C5_562 25870267 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Cryo-EM structure of tetracycline resistance protein TetM bound to a translating E.coli ribosome; 5S ribosomal RNA 3j9z SA 1542 3.6 RF00177,RF01959,RF01960 URS00000ABFE9_562 26229983 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccuua ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<......>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<.......<<<....>>>......>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.............. ........((((..[.[[[..)))).((((..((((..(((((((((....(((.(((..(((..((.((..(((((((((((..)))))))).)))))..)))))......(((......(((((((..((...((.((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))).))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....(((.((.(.......)))..))).....)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))).))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....(.((((...((...((((.........))))...)))))).)......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((.(..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))...((....))..))))).))).((..((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((.(...((..(((.....)))))....).)))))..(..(((((.....))))).....)..)))).....).).)))...)).)).))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..).))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((...(((((((((((....((((((..(((..((....)).))).))))))...)))))))))))...))).))))..).))...)..)..((((((.((....)).))))))}............. Activation of GTP Hydrolysis in mRNA-tRNA Translocation by Elongation Factor G; 16S ribosomal RNA 3j9z S6 77 3.6 RF00005 URS00001BBAFC_274 26229983 0030533 0006412 274 cgcgggguggagcagccugguagcucgucgggcucauaacccgaagaucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Activation of GTP Hydrolysis in mRNA-tRNA Translocation by Elongation Factor G; P-tRNA 3j9z S7 74 3.6 RF00005 URS0000868542_274 26229983 0030533 0006412 274 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcac <<<<<<<..<<<<........>>>>.<<<<<<<...>>>>>>>.....<<<<<.......>>>>>>>>>>>>.. (.(((((..((((.....[..)))).((((.........)))).....((.(...].....).))))))).).. Activation of GTP Hydrolysis in mRNA-tRNA Translocation by Elongation Factor G; E-tRNA 3j9z LA 2904 3.6 RF02540,RF02541 URS0000868550_562 26229983 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacugguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugcagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccuu <<<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<.<<.....>>.>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<.<.<<<...<<<....>>>...>>>..>>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<..<<....>>...>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<.............<<<..<........<<<<<<<<....>>>>>>>>....>.............>>>....>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<<...>>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>.. ((((((((......((((((((((.....(((..(((((((((((((......((.(((.[..[[[.))).....(((((....(((]]]..].)))........)))))....))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...(.((((.....(...[..)......))))..).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((....((((......)))).[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).)..(((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).(((((((.(..(((((((((.....(((...(((.((((...(((.(((.....)).)).))...)))).)))..)).).....)))))).)))...))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((.((((((....)))))).))....))))))(((((((...(((......((((((((....))))))))...)))..))))).)).....))))).(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((..((.(.(((...(((....)))...)))..)))...(((((........)))))]](((.(((((((((...((((....((((..(((..(((((((((((....{{{...))))))((..((((...(((.((((((((.((.....))))))))))...)))...))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))).))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((....((((..).)))....)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(..........(((((..((....))...)))))..........))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......(.((.(.((((..(((((.(((.(((((.(((((((((((.((.(.(.....[{..(..((...((......(((.(((......))).)))...)).....].....}.)).).).).)).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(.(......[).)((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((.(..{.).))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))...))).)......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((.(((......))).))..))).(((((.....))))).....)))))..)...))).))....(.(((((....))).)).)....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((...))))))(....((..(.(((.......))).)....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))).. Activation of GTP Hydrolysis in mRNA-tRNA Translocation by Elongation Factor G; 23S ribosomal RNA 3j9z LB 120 3.6 RF00001 URS0000049E57_562 26229983 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......(((((((.....))))))).......))...)))))))))). Activation of GTP Hydrolysis in mRNA-tRNA Translocation by Elongation Factor G; 5S ribosomal RNA 3ja1 SA 1542 3.6 RF00177,RF01959,RF01960 URS00000ABFE9_562 26229983 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccuua ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<<....>>>>>>>.>>>>>..>>>>>......<<........<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>.<<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>.>..........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.............. ........((((..[.[[[..)))).((((..((((..(((((((((....(((.(((..(((..((.((..(((((((((((..)))))))).)))))..)))))......(((.......((((((..((...((.((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))).))..)).)))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....(((.((.(.......)))..))).....)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))).))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((.(..((((((((((......((........))..........(((((((..(...(((((((..(((.(((....))).)))...((....))..))))).))).((..((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((..((((.(...((..(((.....)))))....).))))...(..(((((.....))))).....)..)))).....).).)))...)).)).))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..).))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((...(((((((((((....(((((...(((..((....)).)))..)))))...)))))))))))...))).))))..).))...)..)..(((((((((....)))))))))}............. Activation of GTP Hydrolysis in mRNA-tRNA Translocation by Elongation Factor G; 16S ribosomal RNA 3ja1 S1 47 3.6 26229983 562 aggauaagugcauuauguuuauguggugauuugcccuucuguagcca ............................................... ............................................... Activation of GTP Hydrolysis in mRNA-tRNA Translocation by Elongation Factor G; mRNA 3ja1 S2 77 3.6 RF00005 URS00001BBAFC_274 26229983 0030533 0006412 274 cgcgggguggagcagccugguagcucgucgggcucauaacccgaagaucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(((((.......)))))))))))..... Activation of GTP Hydrolysis in mRNA-tRNA Translocation by Elongation Factor G; P/E-tRNA 3ja1 LB 120 3.6 RF00001 URS0000049E57_562 26229983 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>>.<<.....<.<<<<<<<<...>>>>>>>>...>...>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......(((((((.....))))))).......))...)))))))))). Activation of GTP Hydrolysis in mRNA-tRNA Translocation by Elongation Factor G; 5S ribosomal RNA 3ja1 LA 2904 3.6 RF02540,RF02541 URS000086854E_562 26229983 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacaccgguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaaccauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcuguguagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuguggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccuu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>...[.....<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))....].]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<.<..<<<<<<<<<.....<<<...<<<.<<<<...<<...<<.....>>....>>...>>>>.>>>..>>.>.....>>>>>>>.>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<.........>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<.<.<<<...<<<....>>>...>>>..>>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<....<<<.....>>>....>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>.>......>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<.<...........<<<...........<.<<<<<......>>>>>.>..................>>>..>.>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>.(<<...<<<<<<<...<<<<<<.......>>>>>>.....<<)..(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<<...>>>>>>.....<<..<<<<.........>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>.. ((((((((......(((((((((......(((..(((((((((((((......((.(((.[..[[[.))).....(((((....(((]]]..].)))........)))))....))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...(.((((.....(...[..)......))))..).........((....))...(((((.....((.]...))....)))))...((((.((((......((((.((((((((.(((....((((......)))).[[(...).(((.....]])))...)))...)))))))).))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............))......))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((.(((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).)).)))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).(((((((.(..(((((((((.....(((...(((.((((...(((.(((.....)).)).))...)))).)))..)).).....)))))).)))...))))))).)...((.((((((........)))))).))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((.((((((....)))))).))....))))))(((((((...(((......((((((((....))))))))...)))..))))).)).....))))))(......((.....((((((.......))))))(.((....((((..((..(((((((...((.....)).))))))....[[(((..((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....((((..(((..(((((((((((....{{{...))))))((..((((...(((.((((((((.((.....))))))))))...)))...))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..)).)..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((....((((..).)))....)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..((.........(((((..((....))...))))).........)))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....))....(((((.....]..)))))..((((((((.(((.((......((((.(.((((..(((((.(((.(((((.(((((((((((.((((.(......[..(..((...(.......(...(((......)))...)....)...........].)).).).)))).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(.(......[).)((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((.(..{.).))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))...)))))........((..(.((((((...((.......))...))))))...).))..........((((..(((((..((.((.(((......))).))...)).(((((.....))))).....)))))......))).).....(.(((((....))).)).)....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((...))))))(....((..(.(((.......))).)....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))).. Activation of GTP Hydrolysis in mRNA-tRNA Translocation by Elongation Factor G; 23S ribosomal RNA 3jag 2 76 3.65 RF00005 URS0000868530_9986 26245381 0030533 9986 gucuccguaguguagcgguuaucacguucgccuaacacgcgaaagguccucgguucgaaaccgggcggaaacacca <<.<<<<..<<<..........>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>.>>.... ((.((((..(((.....[....))).(((((.......))))).....(((((..]....))))))))).)).... Structure of a mammalian ribosomal termination complex with ABCE1, eRF1(AAQ), and the UAA stop codon; tRNA(Val) 3jag 3 75 3.65 RF00005 URS000086855F_9986 26245381 0030533 0006412 9986 gcccggauagcucagcuguagagcaucagacuuuuaaucugaggguccaggguucaagucccuguucgggcgcca <<<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... ((((..(..((((....[..)))).(((((.......))))).....(((((..]....))))))..)))).... Structure of a mammalian ribosomal termination complex with ABCE1, eRF1(AAQ), and the UAA stop codon; tRNA(Lys) 3jag 5 3662 3.65 RF02540,RF02543 URS000086853D_9986 26245381 0003735 0005840 9986 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcggcccggcggaucuuucccgcgcgggggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucggccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcgcucuccccccucccggcgccgccggggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccgggggaggggccacgcgcgcgucccccgaagagggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcacacgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcgugagccgggcguggaauggagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagcggcgggggcggcgcgcgcgcgcgcccgcccccggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcugggucggucgucggccggcgccuagcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacauguuuuuucacugacccggugaggcgggggggcgagccccgaggggcucucgcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccggucccccgcgggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcacgccguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..[[[..<<<<<...<<<<<<<<<<<...>>>>>>>.>>>>.....>>>>>..<<<<<<<<<....<<<<<<<<...<....<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>>..>>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<......<<<<<<<<.<<<.....<<<<<<<<<<<...<<<....<<<<<.<<....<<<<.<<<..<<<<<>>>>>>>>>>>>>>>>.>>>......>>>.>>>>>>>>>>>......>>>.>>>.>>>>>..<<<<<<<..<<<<<<<<<<.<<<....<...<<.<<<.<<<<......<<<<<..>>>>>.......>>>>.>>>>>.........>.>>>...>>>>>>>>>>....................<<<<<..<<<<<<<..<<<<<.>>>>>>>>>>>>..<.<<<.<<<<.<<<<<<<<<<<<<<<<<<<<<<<<.<<<<....>>>>.>>>>>>>>>>.>>>>>>>>>>>.>>>...>.>>>...>>>..>.....<<<<<<<<.....>>>>>>>>........>>>>>.......>>.>>>>>....>>>...>>>>>>>>..<<<<........>>>><<<<<<...<<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<<....>>>>>>>>..<<<<<...<<<..<<<...(((.....>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>>.<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<............<<<<<<<<<...<<<....<<<..<.<<<...<<<.<.<.....>.>.>>>.>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<........>>>>>>>>>...>>...>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<..............))).......................<<<..>>>.......................>>>>>>>>>....>>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<<<<<...>>>>>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<...<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..{{{..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>............>>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<...............>>>>><<.<<<<<<<<<<<...<<<<<<.>>>>>>........>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<<.<<<<<<<<<<..>>>>>>>>>>...<<<<<.....<<<<..<<.<<<<<<<..>>>>>>>>>..............<<<<<<<<<<<.....>>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>>.<<<....>>>.>>)))]......((((((..(((..>>>>>>.)))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]].....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<}}}.>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.....<<<<<<<.<<..<<<.....<<.........<<<<<..<<<<..>>>>.>>>>>........>>....<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>..............>>>..>>>>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<.<..<<<<<......>>>>>..>>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..(((((((((((.....)))))).))))....))))....(((((..((....((((((((.(.(....((((((((..({((((......)))))....[[(...).(((....}]])))...).)))))))).)))))))))...))..)))))..)....((((.((........))).))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((......((((((((.(((.....(((((((((((...(((.(..(((((.((....((((.((...((((())))).)))))))))).)))..)...))).))))))))))).....).)).))).)))))..((((((((.((((.(((((.(((....(...(.((((.((((....(.(((((()))))))......)))).))))).........).)))...))))).))))....................(((((..(((((((..(((((.))))))))))))..((.((.((((..(((((((((((((((((((((((.((((....)))).)))))))))).))))))))))).))....).)))...)))..).....((((((((.....))))))))........)))))......))).)))))....)))...)))))))).[((((........))))((((((....(((((((((((((..(((..(((((........)))).)...)))...((....))...((((((((....))))))))..(((((...(((..(((...[[[...[.)))..)))....))))).(((((((((.((((......))))))))))).))....)))))))))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....((.((....))).)((.(((((((............(.((((((....(((....(((..(.(((..(.((((.(.....).))))).))).)..)))..)).)....))))))...(((((((((........)))))))))....)...)))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.(((((((((......{.((....(((...((.........))...))).....(...((......)).)....))....))))))))))))..........]]].)....))))))))))...)))))))((((((.(((..........]...]]].......................(((..))).......................)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...((..(.(((....))).....)....((.(((((((((...)))))))))))......))....))...(((((........)))))]]((((....(((.....(((((((....)))))))..((((....)))...(...((((((...((((((((((((((((((((((....{{..).))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...))............))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((...((((((.))))))........)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(..(((.....(((.....).)).....))))))))..))))).((((.........)))).........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.(((((((((.((((((((((..))))))))))...(((((.....((((..((.((((((....))))))))..............(((((((((((.....)))))))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(.((((.......).)))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a.))..))).))))).....(((((..(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}..)))))..)).))...))))...)))).((((...((((.....}.......))))...))))..)))...).).))))......(((((..((..(((.....((..........((((..((((())))).)))).........))....((..((((....((((.(((((((......)))))))))))...))))..))..............)))..)).))))).(.(((.(..(.......)..)....((.(((((((.((.....((((.(..(((((......)))))..)))))....))....)))).))).))..))))... Structure of a mammalian ribosomal termination complex with ABCE1, eRF1(AAQ), and the UAA stop codon; 28S ribosomal RNA 3jag 7 120 3.65 RF00001 URS000002B0D5_9986 26245381 0003735 0005840 9986 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. Structure of a mammalian ribosomal termination complex with ABCE1, eRF1(AAQ), and the UAA stop codon; 5S ribosomal RNA 3jag 8 156 3.65 RF00002 URS00004B2C76_9986 26245381 0003735 0005840 9986 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<.<<.....>>>.....(.<<<......>>.............>>>..)...>>>....<<<..>>><<<<<<<<.......>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))((((((((.......)))))))).................... Structure of a mammalian ribosomal termination complex with ABCE1, eRF1(AAQ), and the UAA stop codon; 5.8S ribosomal RNA 3jag 9 1719 3.65 RF01960,RF01959,RF00177 URS000086855E_9986 26245381 0003735 0005840 9986 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgccacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgccccccguggcggcgacgaccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcgggcguccccgccgccucucggccggggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggugcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauu ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<...<<<..........>>>..>>.>>......<<........<<<.<....<<....<<<<.......<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<<<....>>>>>>...>>>>....<<<<<...<......>..>>>>>...........<<<<.<<<<......>>>>>>>>..>>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....<<.<<<<<<.<<<....>>>..>>>>>>..>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<.....<<.<.<<....>>.>.>>.<.<..<<........>.>>.>...<<<<<<.<.......<<...<.......>.<<<<.......>>>>...>>......>.>>>..>>>.......<<....<<<<<<<...............>>>>>>>...>>....>>....<<<<<<..<...<<<<..<<<.<<<<<<<<...<<<......>>>......>>>>>>>>.>>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<........>>>>>>>>>.>..>>>...<<.)).>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<.........<..<<........>>..>.......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<.....<<<...<<<....>>>..>>>.....>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<.<<<<<<<<<..>>>>>>>>>...>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>........ ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..((....((((.......((.....((.(((.....))).))......))..........(((...((((((....))))))...))).....(((((...(......)..)))))...........((((.((((......))))))))..))))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).).....((.(((.((.((......))..)).)))..))......((..(...........)..)).........((((([[......((((.....((..]])).......)))).)))))..)))))).)))..[......(.([[...(.(.((...(((..(.....((.(.(((..))).).))((.....(........)....))..((((((.(.......((..((.......)).(((.......)))....))......).)))..))).......((.(..(.((.((...............)).)).).).))....)....((((.((..(...((((..(((.((((((((...((........))......)))))))).))).......((....))...))))..)..))..)))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.(((........))))))))).)..)))...((.].]))...))...].))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((............((........))..........)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((...(...((.(..((((....(((...(((....)))..)))....))))..).))..)..(..(((((.....)))))....)...)))....))).))).....).))))).....).)))))...)).)))).))).(...((.(((........(.......((..((((....))))..))....).........)))).)......(.....(((((..........))))).....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(.(((.((((.(((..((((.((...(((((.(((((((((..)))))))))...)))))...)).))))..))).)))).))))..)).))))...).))...)..)..(.(((((((....)))))))).}....... Structure of a mammalian ribosomal termination complex with ABCE1, eRF1(AAQ), and the UAA stop codon; 18S ribosomal RNA 3jag hh 12 3.65 26245381 9986 ucaaaguuuaag ............ ............ Structure of a mammalian ribosomal termination complex with ABCE1, eRF1(AAQ), and the UAA stop codon; mRNA 3jah 2 76 3.45 RF00005 URS0000868530_9986 26245381 0030533 9986 gucuccguaguguagcgguuaucacguucgccuaacacgcgaaagguccucgguucgaaaccgggcggaaacacca <<.<<<<..<<<..........>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>.>>.... ((.((((..(((.....[....))).(((((.......))))).....(((((..]....))))))))).)).... Structure of a mammalian ribosomal termination complex with ABCE1, eRF1(AAQ), and the UAG stop codon; tRNA(Val) 3jah 3 75 3.45 RF00005 URS000086855F_9986 26245381 0030533 0006412 9986 gcccggauagcucagcuguagagcaucagacuuuuaaucugaggguccaggguucaagucccuguucgggcgcca <<<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... ((((..(..((((....[..)))).(((((.......))))).....(((((..]....))))))..)))).... Structure of a mammalian ribosomal termination complex with ABCE1, eRF1(AAQ), and the UAG stop codon; tRNA(Lys) 3jah 5 3662 3.45 RF02540,RF02543 URS000086853D_9986 26245381 0003735 0005840 9986 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcggcccggcggaucuuucccgcgcgggggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucggccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcgcucuccccccucccggcgccgccggggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccgggggaggggccacgcgcgcgucccccgaagagggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcacacgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcgugagccgggcguggaauggagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagcggcgggggcggcgcgcgcgcgcgcccgcccccggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcugggucggucgucggccggcgccuagcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacauguuuuuucacugacccggugaggcgggggggcgagccccgaggggcucucgcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccggucccccgcgggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcacgccguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..[[[..<<<<<...<<<<<<<<<<<...>>>>>>>.>>>>.....>>>>>..<<<<<<<<<....<<<<<<<<...<....<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>>..>>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<......<<<<<<<<.<<<.....<<<<<<<<<<<...<<<....<<<<<.<<....<<<<.<<<..<<<<<>>>>>>>>>>>>>>>>.>>>......>>>.>>>>>>>>>>>......>>>.>>>.>>>>>..<<<<<<<..<<<<<<<<<<.<<<....<...<<.<<<.<<<<......<<<<<..>>>>>.......>>>>.>>>>>.........>.>>>...>>>>>>>>>>....................<<<<<..<<<<<<<..<<<<<.>>>>>>>>>>>>....<<<.<<<<.<<<<<<<<<<<<<<<<<<<<<<<<.<<<<....>>>>.>>>>>>>>>>.>>>>>>>>>>>.>>>...>.>>>...>>>........<<<<<<<<.....>>>>>>>>........>>>>>.......>>.>>>>>....>>>...>>>>>>>>..<<<<........>>>><<<<<<...<<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<<....>>>>>>>>..<<<<<...<<<..<<<...(((.....>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>>.<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<............<<<<<<<<<...<<<....<<<..<.<<<...<<<.<.<.....>.>.>>>.>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<........>>>>>>>>>...>>...>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<........<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>....>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<..............))).......................<<<..>>>.......................>>>>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<<<<<...>>>>>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<....<<<<<<<....>>>>>>>...<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..{{{..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>............>>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<...............>>>>><<.<<<<<<<<<<<...<<<<<<.>>>>>>........>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<<.<<<<<<<<<<..>>>>>>>>>>...<<<<<.....<<<<..<<.<<<<<<<..>>>>>>>>>..............<<<<<<<<<<<.....>>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>><<<<....>>>>>>)))]......((((((..(((..>>>>>>.)))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]].....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<}}}.>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.....<<<<<<<.<<..<<<.....<<.........<<<<<..<<<<..>>>>.>>>>>........>>....<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>..............>>>..>>>>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<....<<<<<......>>>>>...>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..(((((((((((.....)))))).))))....))))....(((((..((....((((((((.(.(....((((((((..({((((......)))))....[[(...).(((....}]])))...).)))))))).)))))))))...))..)))))..)....((((.((........))).))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((......((((((((.(((.....(((((((((((...(((.(..(((((.((....((((.((...((((())))).)))))))))).)))..)...))).))))))))))).....).)).))).)))))..((((((((.((((.(((((.(((....(...(.((((.((((....(.(((((()))))))......)))).))))).........).)))...))))).))))....................(((((..(((((((..(((((.))))))))))))..((.((.((((..(((((((((((((((((((((((.((((....)))).)))))))))).))))))))))).))....).)))...)))..).....((((((((.....))))))))........)))))......))).)))))....)))...)))))))).[((((........))))((((((....(((((((((((((..(((..(((((........)))).)...)))...((....))...((((((((....))))))))..(((((...(((..(((...[[[...[.)))..)))....))))).(((((((((.((((......))))))))))).))....)))))))))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....((.((....))).)((.(((((((............(.((((((....(((....(((..(.(((..(.((((.(.....).))))).))).)..)))..)).)....))))))...(((((((((........)))))))))....)...)))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.......(.....(((...((.........))...))).....(...((......)).).....)...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((..........]...]]].......................(((..))).......................)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...((..(.(((....))).....)....((.(((((((((...)))))))))))......))....))...(((((........)))))]]((((....(((.....(((((((....)))))))..((((....)))...(...((((((...((((((((((((((((((((((....{{..).))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...))............))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((...((((((.))))))........)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(..(((.....(((.....).)).....))))))))..)))))..(((.........)))..........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.(((((((((.((((((((((..))))))))))...(((((.....((((..((.((((((....))))))))..............(((((((((((.....)))))))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(.((((.......).)))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a.))..))).))))).....(((((..(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}..)))))..)).))...))))...)))).((((...((((.............))))...))))..)))...).).))))......(((((..((..(((.....((..........((((..((((())))).)))).........))....((..((((....((((.(((((((......)))))))))))...))))..))..............)))..)).))))).(.(((.(..(.......)..)....((.(((((((.((.....((((.(..(((((......)))))..)))))....))....)))).))).))..))))... Structure of a mammalian ribosomal termination complex with ABCE1, eRF1(AAQ), and the UAG stop codon; 28S ribosomal RNA 3jah 7 120 3.45 RF00001 URS000002B0D5_9986 26245381 0003735 0005840 9986 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. Structure of a mammalian ribosomal termination complex with ABCE1, eRF1(AAQ), and the UAG stop codon; 5S ribosomal RNA 3jah 8 156 3.45 RF00002 URS00004B2C76_9986 26245381 0003735 0005840 9986 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<.<<.....>>>.....(.<<<......>>.............>>>..)...>>>....<<<..>>><<<<<<<<.......>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))((((((((.......)))))))).................... Structure of a mammalian ribosomal termination complex with ABCE1, eRF1(AAQ), and the UAG stop codon; 5.8S ribosomal RNA 3jah 9 1719 3.45 RF01960,RF01959,RF00177 URS000086855E_9986 26245381 0003735 0005840 9986 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgccacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgccccccguggcggcgacgaccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcgggcguccccgccgccucucggccggggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggugcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauu ...<<<<..[.((((.>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<...<<<..........>>>..>>.>>......<<........<<<.<....<<....<<<<.......<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<<<....>>>>>>...>>>>....<<<<<...<......>..>>>>>...........<<<<.<<<<......>>>>>>>>..>>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....<<.<<<<<<.<<<....>>>..>>>>>>..>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<.....<<.<.<<....>>.>.>>.<.<..<<........>.>>.>...<<<<<<.<.......<<...<.......>.<<<<.......>>>>...>>......>.>>>..>>>.......<<....<<<<<<<...............>>>>>>>...>>....>>....<<<<<<..<...<<<<..<<<.<<<<<<<<...<<<......>>>......>>>>>>>>.>>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<........>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<..<<<........>>>.>.......>>>>>...<<.<<<..<<<<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<.....<<<...<<<....>>>..>>>.....>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>...>.>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<.<<<<<<<<<..>>>>>>>>>...>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>........ ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..((....((((.......((.....((.(((.....))).))......))..........(((...((((((....))))))...))).....(((((...(......)..)))))...........((((.((((......))))))))..))))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).).....((.(((.((.((......))..)).)))..))......((..(...........)..)).........((((([[......((((.....((..]])).......)))).)))))..)))))).)))..[......(.([[...(.(.((...(((..(.....((.(.(((..))).).))((.....(........)....))..((((((.(.......((..((.......)).(((.......)))....))......).)))..))).......((.(..(.((.((...............)).)).).).))....)....((((.((..(...((((..(((.((((((((...((........))......)))))))).))).......((....))...))))..)..))..)))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.(((........))))))))).)..)))...((.].]))...))...].))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.........(..((........)).)........)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((...(...((.(..((((....(((...(((....)))..)))....))))..).))..)..(..(((((.....)))))....)...)))....))).))).....).))))).....).)))))...)).)))).))).(...((.(((........(.......(((.((((....)))).)))....).........)))).)......(.....(((((..........))))).....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(.(((.((((.(((..((((.((...(((((.(((((((((..)))))))))...)))))...)).))))..))).)))).))))..)).))))...).))...)..)..(.(((((((....)))))))).}....... Structure of a mammalian ribosomal termination complex with ABCE1, eRF1(AAQ), and the UAG stop codon; 18S ribosomal RNA 3jah hh 12 3.45 26245381 9986 ucaaaguuuagg ............ ............ Structure of a mammalian ribosomal termination complex with ABCE1, eRF1(AAQ), and the UAG stop codon; mRNA 3jai 2 76 3.65 RF00005 URS0000868530_9986 26245381 0030533 9986 gucuccguaguguagcgguuaucacguucgccuaacacgcgaaagguccucgguucgaaaccgggcggaaacacca <<.<<<<..<<<..........>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>.>>.... ((.((((..(((.....[....))).(((((.......))))).....(((((..]....))))))))).)).... Structure of a mammalian ribosomal termination complex with ABCE1, eRF1(AAQ), and the UGA stop codon; tRNA(Val) 3jai 3 75 3.65 RF00005 URS000086855F_9986 26245381 0030533 0006412 9986 gcccggauagcucagcuguagagcaucagacuuuuaaucugaggguccaggguucaagucccuguucgggcgcca <<<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... ((((..(..((((....[..)))).(((((.......))))).....(((((..]....))))))..)))).... Structure of a mammalian ribosomal termination complex with ABCE1, eRF1(AAQ), and the UGA stop codon; tRNA(Lys) 3jai 5 3662 3.65 RF02540,RF02543 URS000086853D_9986 26245381 0003735 0005840 9986 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcggcccggcggaucuuucccgcgcgggggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucggccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcgcucuccccccucccggcgccgccggggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccgggggaggggccacgcgcgcgucccccgaagagggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcacacgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcgugagccgggcguggaauggagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagcggcgggggcggcgcgcgcgcgcgcccgcccccggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcugggucggucgucggccggcgccuagcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacauguuuuuucacugacccggugaggcgggggggcgagccccgaggggcucucgcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccggucccccgcgggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcacgccguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..[[[..<<<<<...<<<<<<<<<<<...>>>>>>>.>>>>.....>>>>>..<<<<<<<<<....<<<<<<<<..<<....<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>>>.>>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<......<<<<<<<<.<<<.....<<<<<<<<<<<...<<<....<<<<<.<<....<<<<.<<<..<<<<<>>>>>>>>>>>>>>>>.>>>......>>>.>>>>>>>>>>>......>>>.>>>.>>>>>..<<<<<<<..<<<<<<<<<..<<<....<...<..<<<.<<<<......<<<<<..>>>>>.......>>>>.>>>.>.........>.>>>....>>>>>>>>>....................<<<<<..<<<<<<<..<<<<<.>>>>>>>>>>>>....<<<.<<<<.<<<<<<<<<<<<<<<<<<<<<<<<.<<<<....>>>>.>>>>>>>>>>.>>>>>>>>>>>.>>>...>.>>>...>>>........<<<<<<<<.....>>>>>>>>........>>>>>.......>>.>>>>>....>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<<....>>>>>>>>..<<<<<...<<<..<<<...(((.....>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>(><<.<<<<<<<............<<<<<<<<<...<<<....<<<..<.<<<...<<<.<.<.....>.>.>>>.>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<........>>>>>>>>>...>>...>>>>>>>..>>).<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<........<<<<..<<....<<.........>>....>>.........<<......>>....>>>>....>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<..............))).......................<<<..>>>.......................>>>>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<<<<<...>>>>>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<...<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..{{{..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>............>>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>.>>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<...............>>>>><<.<<<<<<<<<<<...<<<<<<.>>>>>>........>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<<.<<<<<<<<<<..>>>>>>>>>>...<<<<<.....<<<<..<<.<<<<<<<..>>>>>>>>>..............<<<<<<<<<<<.....>>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>><<<<....>>>>>>)))]......((((((..(((..>>>>>>.)))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<........>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]].....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<}}}.>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.....<<<<<<<.<<..<<<.....<<.........<<<<<..<<<<..>>>>.>>>>>........>>....<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>..............>>>..>>>>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<....<<<<<......>>>>>...>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..(((((((((((.....)))))).))))....))))....(((((..((....((((((((.(.(....((((((((..({((((......)))))....[[(...).(((....}]])))...).)))))))).)))))))))...))..)))))..)....((((.((........))).))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((......((((((((.(((.....(((((((((((...(((.(..(((((.((....((((.((...((((())))).)))))))))).)))..)...))).))))))))))).....).)).))).)))))..((((((((.((((((((((.(((....(...(.((((.((((....(.(((((()))))))......)))).))))).........).)))...))))))))))....................(((((..(((((((..(((((.))))))))))))..((.((.((((..(((((((((((((((((((((((.((((....)))).)))))))))).))))))))))).))....).)))...)))..).....((((((((.....))))))))........)))))......))).)))))....)))...)))))))).[((((........))))((((((....(((((((((((((..(((..(((((........)))).)...)))...((....))...((((((((....))))))))..(((((...(((..(((...[[[...[.)))..)))....))))).(((((((((.((((......))))))))))).))....)))))))))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((............(.((((((....(((....(((..(.(((..(.((((.(.....).))))).))).)..)))..)).)....))))))...(((((((((........)))))))))....)...)))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.....{.(.....(((...((.........))...))).....(...((......)).).....)...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((..........]...]]].......................(((..))).......................)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...((..(.(((....))).....)....((.(((((((((...)))))))))))......))....))...(((((........)))))]]((((....(((.....(((((((....)))))))..((((....)))...(...((((((...((((((((((((((((((((((....{{..).))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...))............))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((...((((((.))))))........)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(..(((.....(((.....).)).....))))))))..))))).((((.........)))).........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.(((((((((.((((((((((..))))))))))...(((((.....((((..((.((((((....))))))))..............(((((((((((.....)))))))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(.((((.......).)))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a.))..))).))))).....(((((..(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}..)))))..)).))...))))...)))).((((...((((.....}.......))))...))))..)))...).).))))......(((((..((..(((.....((..........((((..((((())))).)))).........))....((..((((....((((.(((((((......)))))))))))...))))..))..............)))..)).))))).(.(((.(..(.......)..)....((.(((((((.((.....((((.(..(((((......)))))..)))))....))....)))).))).))..))))... Structure of a mammalian ribosomal termination complex with ABCE1, eRF1(AAQ), and the UGA stop codon; 28S ribosomal RNA 3jai 7 120 3.65 RF00001 URS000002B0D5_9986 26245381 0003735 0005840 9986 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. Structure of a mammalian ribosomal termination complex with ABCE1, eRF1(AAQ), and the UGA stop codon; 5S ribosomal RNA 3jai 8 156 3.65 RF00002 URS00004B2C76_9986 26245381 0003735 0005840 9986 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<.<<.....>>>.....(.<<<......>>.............>>>..)...>>>....<<<..>>><<<<<<<<.......>>>>>>>>.................... .........................................((((((.[[....[)))...].(.(((......]].............)))..)...)))....((....))((((((((.......)))))))).................... Structure of a mammalian ribosomal termination complex with ABCE1, eRF1(AAQ), and the UGA stop codon; 5.8S ribosomal RNA 3jai 9 1719 3.65 RF01960,RF01959,RF00177 URS000086855E_9986 26245381 0003735 0005840 9986 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgccacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgccccccguggcggcgacgaccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcgggcguccccgccgccucucggccggggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggugcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauu ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<.........<<<.<<<..<<....<<...<<<..........>>>..>>.>>......<<........<<<.<....<<....<<<<.......<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<<<....>>>>>>...>>>>....<<<<<...<......>..>>>>>...........<<<<.<<<<......>>>>>>>>..>>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>......>>.>.....<<.<<<<<<.<<<....>>>..>>>>>>..>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<.....<<.<.<<....>>.>.>>.<.<..<<........>.>>.>...<<<<<<.<.......<<...<.......>.<<<<.......>>>>...>>......>.>>>..>>>.......<<....<<<<<<<...............>>>>>>>...>>....>>....<<<<<<..<...<<<<..<<<.<<<<<<<<...<<<......>>>......>>>>>>>>.>>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<........>>>>>>>>>.>..>>>...<<.)).>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<.<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>>>.......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<.....<<<...<<<....>>>..>>>.....>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>..>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<.<<<<<<<<<..>>>>>>>>>...>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>........ ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..((....((((.......((.....((.(((.....))).))......))..........(((...((((((....))))))...))).....(((((...(......)..)))))...........((((.((((......))))))))..))))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).).....((.(((.((.((......))..)).)))..))......((..(...........)..)).........((((([[......((((.....((..]])).......)))).)))))..)))))).)))..[......(.([[...(.(.((...(((..(.....((.(.(((..))).).))((.....(........)....))..((((((.(.......((..((.......)).(((.......)))....))......).)))..))).......((.(..(.((.((...............)).)).).).))....)....((((.(...(...((((..(((.((((((((...((........))......)))))))).))).......((....))...))))..)...)..)))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.(((........))))))))).)..)))...((.].]))...))...].))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.........(..((........)).)........)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((...(...((((..((((....(((...(((....)))..)))....))))..))))..)..(..(((((.....)))))....)...)))....))).))).....).))))).....).)))))...)).)))).))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(.(((.((((.(((..((((.((...(((((.(((((((((..)))))))))...)))))...)).))))..))).)))).))))..)).))))...).))...)..)..(.(((((((....)))))))).}....... Structure of a mammalian ribosomal termination complex with ABCE1, eRF1(AAQ), and the UGA stop codon; 18S ribosomal RNA 3jai hh 12 3.65 26245381 9986 ucaaaguuugag ............ ............ Structure of a mammalian ribosomal termination complex with ABCE1, eRF1(AAQ), and the UGA stop codon; mRNA 3jaj 5 3658 3.75 RF02540,RF02543 URS000086855C_9986 26158507 0003735 0005840 9986 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcggcccggcggaucuuucccgcgcgggggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucggccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcgcucuccccccucccggcgccgccggggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccgggggaggggccacgcgcgcgucccccgaagagggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcacacgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcgugagccgggcguggaauggagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagcggcgggggcggcgcgcgcgcgcgcccgcccccggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcugggucggucgucggccggcgccuagcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacauguuuuuucacugacccggugaggcgggggggcgagccccgaggggcucucgcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccggucccccgcgggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcacgccguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucgcugcgaucuauugaaagucagcccucgacacaaggguuugu ..........................<<<<<.....<......>......>>>>>...........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<<...<<<<<<<<<<<...>>>>>>>.>>>>.....>>>>>..<<<<<<<<<....<<<<<<<<........<<<<<<<.....<<<<......>>>>.....((......<<<.....))>>>.....>>>>>>>...>>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..(((((.>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<.......<<<<<<<.<<<.....<<<<<<<<<<<...<<<....<<<<<.<<....<<<<.<<<..<<<<<>>>>>>>>>>>>>>>>.>>>......>>>.>>>>>>>>>>>......>>>.>>>.>>>>...<<<<<<<..<<<<<<<<<..<<<....<...<<.<<<.<<<<...<..<<<<<..>>>>>..>....>>>>.>>>>>.........>.>>>....>>>>>>>>>.....................<<<<..<<<<<<...<<<<<.>>>>>.>>>>>>....<<<.<<<<.<<<<<<<<<<<<<<<<<<<<<<<<.<<<<....>>>>.>>>>>>>>>>.>>>>>>>>>>>.>>>...>.>>>...>>>........<<<<<<<<.....>>>>>>>>........>>>>........>>.>>>>>....>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<<....>>>>>>>>..<<<<<...<<<..<<<...(((..[[.>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<......<<<....>>><.<<<<<<<<<<............<<<<<<<<<...<<<....<<<....<<<..<.<<<<.<.....>.>>>>>.>>>....>>>..>.>>...>>>>>>>...<<<<<<<<<........>>>>>>>>>...>>...>>>>>>>.>>>>.<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<..<<<<<<<<<.....<.<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>.>.>>>>>>>>>.>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<..........]]..))).......................<<<..>>>.......................>>>>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<<<<<...>>>>>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<...<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<<<<<<<<<<<...[[[...>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>.>.>>>>>>>>>>>>.........>>>>>>>..>..........>..>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>.>>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<.<<<<<.<<<<<...<<<<<<.>>>>>>........>>>>>...>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<....<.....<<<<....>>>>.....>..>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<..<<<<<<<<<.<<<<<<<<<<..>>>>>>>>>>...<<<<<.....<<<<..<<.<<<<<<....>>>>>>>>..............<<<<<<<<<<<.....>>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>...>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<....<<<<<<.......>>>>>>.....<..[.(((.>.....>>>>>>...<<<..<<<<.......>>>>..>>>.<<<....>>>.>>)))]......<<<<<<..<<<...))))).>>>>>>>>>..........>>>>..>>>>>>.......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<.<<<.<<<<<<..<.<.<<<<........>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>..>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<...<<<.<<<<<<.]]]..>>>>..>>.>>>..>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.....<<<<<<<.<<..<<<.....<<.........<<<<<..<<<<..>>>>.>>>>>........>>....<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>..............>>>..>>>>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<....<<<<<..>>>>>...>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(.(((..........[..........)))..).........((....))...((((......((.]...)).....))))...((((...(((...(((.((((((.....))))))..))).....)))....((((...((....((((((((........(((((((...({((((......)))))....[[(...).(((....}]]))).....)))))))...))))))))...))...)).)).)....((((.((........))).))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.......(((((((.((......(((((((((((...(((....(..((.((....((((.(((..((((())))))))))))))))...)......))).))))))))))).......)).))).))))...((((((((.((((.(((((.(((....(...(...((.((((.........((()))..........)))).))..).........).)))...))))).))))....................(((((...(((((...(((((.))))).)))))...((..(.((((..(((((((((((((((((((((((..(((....)))..)))))))))).))))))))))).))....).)))..)..)..).....((((((((.....))))))))........)))))......))).)))))....)))...)))))))).[((((........))))((((((.....((((((((((((..(((..(((((........)))).)...)))..............((((((((....))))))))..(((((...(((..(((....[[...[.)))..)))....))))).(((((.(((..(((......))).))).))).))....))))))))))))...((.(...((((((.....(((((..((..((((...(((((((....)))))))...)<)))...(((..((.((.......B)))).)))....))..))))).(.((.......))...)..))))))......).))..((((((.....(.((....)))..((.(((.(((............(.((((((....(((....(((..(.(((....((((.(.....).))))..))).)..)))..)).)....))))))...(((((((((........)))))))))....)...))).)))..))..((((.(((((.....))))).)))).....((......))....(((((((...((([[[...(.(.(((........(..........((.A..((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...))))))))...))..........]]].)......))))))))...)))))))...(((.(((..........]...]]........................(((..))).......................)))))).......)))))).(.(.((((((.((......(((..((((....)))).)))...)))))))).)..).....))))))((.....((.....((((((.......)))))).(.(.....((((..((...((((((...((.....)).))))))....[[(((.((...((....(((....)))..........((.((((.(.((...)).).))))))......))....))...(((((........)))))]]((((....(((.....((((..(....)..))))..(.((....))....(...((((((...(...((((((((((((((((((....{{..).))))....(.....((((.((((.....(((.....))).....))))))))......).....((((((((....).))))))))))).).))))))))...)(...)....))))))...))............))).)))).)))..)).....((......)).)))).((((.....))))..).)....((((.....(((((.(.((..(....(.......(((((....(.[..).....)))))((.((((..(((((...((((((.))))))........)))))....)))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).]...(.(((..((((((.................................))))..)))))(.(((.........)))..).......((............((.........))....)..)....)......)).))))))).)..))).).)))))..))))))....)).{..(((((.....]}.)))))....(((((..(...((......((((.((((((..(((((.(((((((...(((((.((((..)))).)))))...(.........((((.....((((((....))))))................(((((((((((.....)))))))))))..))))......)......)))))))..)))))..(((.......)).)((((((...........))))))(......(.((....(.((((((.......))))))...)......[[..........)).).(.(((..((((....{..))))..))))(((....)))....]]..........(((..(((..]]]]]].)))))).......)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((......((((.......).))).......(((.(.....).))).....)))))..)...))).).....(...(((....)))....)..b.))....).))))).....(((.(..(..(((..(.(((((......(....).....))))).)((((....(((.....((.(((((((}}..)))))..)).))....)))...)))).((((...((((...a.}.......))))...))))..)))...).)..)))......(((.(......(((.....((..........((((..((((())))).)))).........))........((((....((((.(((((((......)))))))))))...))))..................))).....).))).(((((.(.............)....((.(((..((........((((.(..(((((..)))))..)))))..........))...))).))..))))).. Structure of the engaged state of the mammalian SRP-ribosome complex; 28S ribosomal RNA 3jaj 7 120 3.75 RF00001 URS000002B0D5_9986 26158507 0003735 0005840 9986 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. ((((((.......((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))...)))))).. Structure of the engaged state of the mammalian SRP-ribosome complex; 5S ribosomal RNA 3jaj 8 156 3.75 RF00002 URS00004B2C76_9986 26158507 0003735 0005840 9986 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<.<<.....>>>.......<<<......>>.............>>>......>>>....<<<..>>><<<<<<<<.......>>>>>>>>.................... .........................................((((((.[[.....))).......(((......]].............)))......)))....((....))((((.(((.......))).)))).................... Structure of the engaged state of the mammalian SRP-ribosome complex; 5.8S ribosomal RNA 3jaj 3 76 3.75 RF00005 URS0000868532_9986 26158507 0030533 9986 guuuccguaguguagugguuaucacguucgccuaacacgcgaaagguccccgguucgaaaccgggcggaaacacca <<<<<<<..<<<..........>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..(((..........))).((((.........)))).....(((((.......)))))))))))).... Structure of the engaged state of the mammalian SRP-ribosome complex; Val tRNA 3jaj S2 1742 3.75 RF01960,RF01959,RF00177 URS000080E1CB_9986 26158507 0003735 0005840 9986 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucgcuccucucccacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgccccccguggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuccgcgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcgggcguccccgccgccucucggccggggcccgaagcauuuacuuugaaaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggucggcccacggcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<...((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<...<<<..........>>>..>>.>>......<<........<<<.<....<<....<<<<<..................<<.....<<.............>>......>>.........<<<<...<<<<<<....>>>>>>...>>>>....<<<<<...<......>..>>>>>...........<<<<.<<<<......>>>>>>>>.>>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>...<<....>>.....>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....<<.<<<.<..<<<....>>>..>..>>>..>>......<<..<...........>..>>.........<<<<<((......<<<<.........)).........>>>>.>>>>>..>>>>>>.>>>.........<.<(......<.<<...<<<.<<.....<<.<.<<....>>.>.>><<.<...............>.>>..<<<<<<.<.......<<...<.......>.<<<<.......>>>>...>>......>.>>>..>>>.......<<....<<<<<<<...............>>>>>>>...>>....>>....<<<<<<..<...<<<<..<<<.<<<<<<<<...<<<......>>>......>>>>>>>>.>>>.......<......>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<..).>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..))))....<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<.......<<........>>..........<<<<<......<<<<<............<<........>>..........>>>>>...<<.<<<..<<<<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<....<<<...<<<....>>>..>>>....>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>...>.>>>>>>>.......>>>>>....>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.......<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<.<<<<<<<<<<<<.....>>>>>>>>>>>>...>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>......<<<<<<<<....>>>>>>>>.......... ...((((....[[[..))))(((.....((...(.((..((.....(((..((...(....((....((..........))...))[).......(((.......(((.(.(..((....(((((..................((.....((.............))......))..........(((...((((((....))))))...)))....(.((((...(......)..)))))...........((((..(((......))).)))).)).)))...))).).))).((.....(((....(((((((........).))))))))).......))...(((.(.(.......))....)))))).((.(((..........))).))....(....)......)).))).).....(.(((...((((.]...))).))))).)...)).).....((.(((.(..(((....)))..)..)))..))......((..(...........)..))..........(((([[......((((.....((..]])).......)))).))).)..)).....))).........(.([....(.(.((...(((..(......(.(.((....)).).).((...................))..(((((..(.......((..............(((.......)))....))......)..))..))).......((.(..(.((.((...............)).)).).).))....)....(((..(...(...((((..(((.((((((((...(..........)......)))))))).)))..................))))..)...)...))..))))...)).)....((((((....(....(((.........)))....).))))))......{...(((....(((....((((((...............))))))....)))...((..].))..........))))).).(((......((((....))))....)))...]]].(....(.(((((((..((...((((..(((..(((((......((........))..........(((((......((((..........(...............).........))))...((.(((...(.((((((....(((.(((((....)))..(..(......).)...)).)))....(((...(...((((..((((....(((...(((....)))..)))....))))..))))..)..(..(((((.....)))))....)...)))....))).))).....).))))).......)))))...)).)))..))).(...(..(((........(.......(((.((((....)))).)))....).........)))..)......(.....(((((..........))))).....)..)..))).).....((((((.(.......).))))))......))...))))))))....)..(.(..((.(..((((.((..(.((((.(...(((..((((.((...((.((.(((((((((.((.....)).)))))))))...)).))...)).))))..)))...).)))))..)).))))...).))...)..)..(.(((((((....)))))))).}........ Structure of the engaged state of the mammalian SRP-ribosome complex; 18S ribosomal RNA 3jan 5 3658 3.75 RF02540,RF02543 URS000086855C_9986 26158507 0003735 0005840 9986 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcggcccggcggaucuuucccgcgcgggggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucggccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcgcucuccccccucccggcgccgccggggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccgggggaggggccacgcgcgcgucccccgaagagggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcacacgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcgugagccgggcguggaauggagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagcggcgggggcggcgcgcgcgcgcgcccgcccccggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcugggucggucgucggccggcgccuagcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacauguuuuuucacugacccggugaggcgggggggcgagccccgaggggcucucgcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccggucccccgcgggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcacgccguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucgcugcgaucuauugaaagucagcccucgacacaaggguuugu ..........................<<<<<.....<......>......>>>>>...........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<<...<<<<<<<<<<<...>>>>>>>.>>>>.....>>>>>..<<<<<<<<<....<<<<<<<<........<<<<<<<.....<<<<......>>>>.....((......<<<.....))>>>.....>>>>>>>...>>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..(((((.>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<.......<<<<<<<.<<<.....<<<<<<<<<<<...<<<....<<<<<.<<....<<<<.<<<..<<<<<>>>>>>>>>>>>>>>>.>>>......>>>.>>>>>>>>>>>......>>>.>>>.>>>>...<<<<<<<..<<<<<<<<<..<<<....<...<<.<<<.<<<<...<..<<<<<..>>>>>..>....>>>>.>>>>>.........>.>>>....>>>>>>>>>.....................<<<<..<<<<<<...<<<<<.>>>>>.>>>>>>....<<<.<<<<.<<<<<<<<<<<<<<<<<<<<<<<<.<<<<....>>>>.>>>>>>>>>>.>>>>>>>>>>>.>>>...>.>>>...>>>........<<<<<<<<.....>>>>>>>>........>>>>........>>.>>>>>....>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<<....>>>>>>>>..<<<<<...<<<..<<<...(((..[[.>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<......<<<....>>><.<<<<<<<<<<............<<<<<<<<<...<<<....<<<....<<<..<.<<<<.<.....>.>>>>>.>>>....>>>..>.>>...>>>>>>>...<<<<<<<<<........>>>>>>>>>...>>...>>>>>>>.>>>>.<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<..<<<<<<<<<.....<.<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>.>.>>>>>>>>>.>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<..........]]..))).......................<<<..>>>.......................>>>>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<<<<<...>>>>>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<...<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<<<<<<<<<<<...[[[...>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>.>.>>>>>>>>>>>>.........>>>>>>>..>..........>..>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>.>>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<.<<<<<.<<<<<...<<<<<<.>>>>>>........>>>>>...>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<....<.....<<<<....>>>>.....>..>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<..<<<<<<<<<.<<<<<<<<<<..>>>>>>>>>>...<<<<<.....<<<<..<<.<<<<<<....>>>>>>>>..............<<<<<<<<<<<.....>>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>...>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<....<<<<<<.......>>>>>>.....<..[.(((.>.....>>>>>>...<<<..<<<<.......>>>>..>>>.<<<....>>>.>>)))]......<<<<<<..<<<...))))).>>>>>>>>>..........>>>>..>>>>>>.......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<.<<<.<<<<<<..<.<.<<<<........>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>..>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<...<<<.<<<<<<.]]]..>>>>..>>.>>>..>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.....<<<<<<<.<<..<<<.....<<.........<<<<<..<<<<..>>>>.>>>>>........>>....<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>..............>>>..>>>>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<....<<<<<..>>>>>...>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(.(((..........[..........)))..).........((....))...((((......((.]...)).....))))...((((...(((...(((.((((((.....))))))..))).....)))....((((...((....((((((((........(((((((...({((((......)))))....[[(...).(((....}]]))).....)))))))...))))))))...))...)).)).)....((((.((........))).))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.......(((((((.((......(((((((((((...(((....(..((.((....((((.(((..((((())))))))))))))))...)......))).))))))))))).......)).))).))))...((((((((.((((.(((((.(((....(...(...((.((((.........((()))..........)))).))..).........).)))...))))).))))....................(((((...(((((...(((((.))))).)))))...((..(.((((..(((((((((((((((((((((((..(((....)))..)))))))))).))))))))))).))....).)))..)..)..).....((((((((.....))))))))........)))))......))).)))))....)))...)))))))).[((((........))))((((((.....((((((((((((..(((..(((((........)))).)...)))..............((((((((....))))))))..(((((...(((..(((....[[...[.)))..)))....))))).(((((.(((..(((......))).))).))).))....))))))))))))...((.(...((((((.....(((((..((..((((...(((((((....)))))))...)<)))...(((..((.((.......B)))).)))....))..))))).(.((.......))...)..))))))......).))..((((((.....(.((....)))..((.(((.(((............(.((((((....(((....(((..(.(((....((((.(.....).))))..))).)..)))..)).)....))))))...(((((((((........)))))))))....)...))).)))..))..((((.(((((.....))))).)))).....((......))....(((((((...((([[[...(.(.(((........(..........((.A..((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...))))))))...))..........]]].)......))))))))...)))))))...(((.(((..........]...]]........................(((..))).......................)))))).......)))))).(.(.((((((.((......(((..((((....)))).)))...)))))))).)..).....))))))((.....((.....((((((.......)))))).(.(.....((((..((...((((((...((.....)).))))))....[[(((.((...((....(((....)))..........((.((((.(.((...)).).))))))......))....))...(((((........)))))]]((((....(((.....((((..(....)..))))..(.((....))....(...((((((...(...((((((((((((((((((....{{..).))))....(.....((((.((((.....(((.....))).....))))))))......).....((((((((....).))))))))))).).))))))))...)(...)....))))))...))............))).)))).)))..)).....((......)).)))).((((.....))))..).)....((((.....(((((.(.((..(....(.......(((((....(.[..).....)))))((.((((..(((((...((((((.))))))........)))))....)))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).]...(.(((..((((((.................................))))..)))))(.(((.........)))..).......((............((.........))....)..)....)......)).))))))).)..))).).)))))..))))))....)).{..(((((.....]}.)))))....(((((..(...((......((((.((((((..(((((.(((((((...(((((.((((..)))).)))))...(.........((((.....((((((....))))))................(((((((((((.....)))))))))))..))))......)......)))))))..)))))..(((.......)).)((((((...........))))))(......(.((....(.((((((.......))))))...)......[[..........)).).(.(((..((((....{..))))..))))(((....)))....]]..........(((..(((..]]]]]].)))))).......)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((......((((.......).))).......(((.(.....).))).....)))))..)...))).).....(...(((....)))....)..b.))....).))))).....(((.(..(..(((..(.(((((......(....).....))))).)((((....(((.....((.(((((((}}..)))))..)).))....)))...)))).((((...((((...a.}.......))))...))))..)))...).)..)))......(((.(......(((.....((..........((((..((((())))).)))).........))........((((....((((.(((((((......)))))))))))...))))..................))).....).))).(((((.(.............)....((.(((..((........((((.(..(((((..)))))..)))))..........))...))).))..))))).. Structure of the scanning state of the mammalian SRP-ribosome complex; 28S ribosomal RNA 3jan 7 120 3.75 RF00001 URS000002B0D5_9986 26158507 0003735 0005840 9986 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. ((((((.......((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))...)))))).. Structure of the scanning state of the mammalian SRP-ribosome complex; 5S ribosomal RNA 3jan 8 156 3.75 RF00002 URS00004B2C76_9986 26158507 0003735 0005840 9986 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<.<<.....>>>.......<<<......>>.............>>>......>>>....<<<..>>><<<<<<<<.......>>>>>>>>.................... .........................................((((((.[[.....))).......(((......]].............)))......)))....((....))((((.(((.......))).)))).................... Structure of the scanning state of the mammalian SRP-ribosome complex; 5.8S ribosomal RNA 3jan 3 76 3.75 RF00005 URS0000868532_9986 26158507 0030533 9986 guuuccguaguguagugguuaucacguucgccuaacacgcgaaagguccccgguucgaaaccgggcggaaacacca <<<<<<<..<<<..........>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..(((..........))).((((.........)))).....(((((.......)))))))))))).... Structure of the scanning state of the mammalian SRP-ribosome complex; Val tRNA 3jan S2 1742 3.75 RF01960,RF01959,RF00177 URS000080E1CB_9986 26158507 0003735 0005840 9986 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucgcuccucucccacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgccccccguggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuccgcgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcgggcguccccgccgccucucggccggggcccgaagcauuuacuuugaaaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggucggcccacggcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<...((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<...<<<..........>>>..>>.>>......<<........<<<.<....<<....<<<<<..................<<.....<<.............>>......>>.........<<<<...<<<<<<....>>>>>>...>>>>....<<<<<...<......>..>>>>>...........<<<<.<<<<......>>>>>>>>.>>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>...<<....>>.....>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....<<.<<<.<..<<<....>>>..>..>>>..>>......<<..<...........>..>>.........<<<<<((......<<<<.........)).........>>>>.>>>>>..>>>>>>.>>>.........<.<(......<.<<...<<<.<<.....<<.<.<<....>>.>.>><<.<...............>.>>..<<<<<<.<.......<<...<.......>.<<<<.......>>>>...>>......>.>>>..>>>.......<<....<<<<<<<...............>>>>>>>...>>....>>....<<<<<<..<...<<<<..<<<.<<<<<<<<...<<<......>>>......>>>>>>>>.>>>.......<......>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<..).>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..))))....<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<.......<<........>>..........<<<<<......<<<<<............<<........>>..........>>>>>...<<.<<<..<<<<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<....<<<...<<<....>>>..>>>....>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>...>.>>>>>>>.......>>>>>....>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.......<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<.<<<<<<<<<<<<.....>>>>>>>>>>>>...>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>......<<<<<<<<....>>>>>>>>.......... ...((((....[[[..))))(((.....((...(.((..((.....(((..((...(....((....((..........))...))[).......(((.......(((.(.(..((....(((((..................((.....((.............))......))........(.(((...((((((....))))))...))))...(.((((...(......)..)))))...........((((..(((......))).)))).)).)))...))).).))).((.....(((....(((((((........).))))))))).......))...(((.(.(.......))....)))))).((.(((..........))).))....(....)......)).))).).....(.(((...((((.]...))).))))).)...)).).....((.(((.(..(((....)))..)..)))..))......((..(...........)..))..........(((([[......((((.....((..]])).......)))).))).)..)).....))).........(.([....(.(.((...(((..(......(.(.((....)).).).((...................))..(((((..(.......((..............(((.......)))....))......)..))..))).......((.(..(.((.((...............)).)).).).))....)....(((..(...(...((((..(((.((((((((...(..........)......)))))))).)))..................))))..)...)...))..))))...)).)....((((((....(....(((.........)))....).))))))......{...(((....(((....((((((...............))))))....)))...((..].))..........))))).).(((......((((....))))....)))...]]].(....(.(((((((..((...((((..(((..(((((......((........))..........(((((......((((..........(...............).........))))...((.(((...(.((((((....(((.(((((....)))..(..(......).)...)).)))....(((...(...((((..((((....(((...(((....)))..)))....))))..))))..)..(..(((((.....)))))....)...)))....))).))).....).))))).......)))))...)).)))..))).(...(..(((........(.......(((.((((....)))).)))....).........)))..)......(.....(((((..........))))).....)..)..))).).....((((((.(.......).))))))......))...))))))))....)..(.(..((.(..((((.((..(.((((.(...(((..((((.((...((.((.(((((((((.((.....)).)))))))))...)).))...)).))))..)))...).)))))..)).))))...).))...)..)..(.(((((((....)))))))).}........ Structure of the scanning state of the mammalian SRP-ribosome complex; 18S ribosomal RNA 3jap 1 75 4.9 RF00005 URS000080E1DE_28985 26212456 0030533 0006412 28985 agcgccguggcgcaguggaagcgcgcaggucucauaaaccugauguccucggaucgaaaccgagcggcgcuacca <<<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.......)))).(((((.......))))).....(((((.......)))))))))))).... Structure of a partial yeast 48S preinitiation complex in closed conformation; Met-tRNAi (U31:A39 variant) 3jap 2 1780 4.9 RF01960,RF01959,RF00177 URS0000868552_28985 26212456 0003735 0005840 28985 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacauggauaucugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacuccuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaacuggagggcaagucuggugccagcagccgcgguaauuccagcuccaguagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggucugguuguccggucgguuuuucaaccggaucuuuccuucuggcuaaccuguacuccuugugggugcaggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcgaaagcucgaauauauuagcauggaauaauggaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuucuuaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaggguugcuggcacuugccgguugacucuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgaguacaaccuuggccgagaggucuggguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggauuugcuuagagaagggggcaacuccaucucagagcgaagaaucuggucaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<...[[[[>>>>>[[[..((((((................[[[.[[[..<<....<<....<<..........>>..>.>.>>......{{........[[[..{{..{.....[[[{...............<<.....<<.<<.......>>.>>......>>........<<<<<..<<....>>..>>>>>{..[[.((((......<<<<<<<<<<<....>>>..............))))]].....}...<<<<..<<<.....>>>.>>>>..}.]]]....}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>...<<....>>.....]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<<<<<<<<......>>>>>>>>>.>>>......<...<...........>...>.........<<<<<((....<.<<<<.........)).........>>>>>>>>>>..)))))).]]].........[[[{{.......{{...[[[.[[....<.<<<<<<<<<.....<..>.....>>>>>>>>>.>....<<<<<<....<.<<<.<<.......>>.>>>.>....>>>>>>...<<<<<.<<.......<<...<.......>..<<<....>.>>...>>......>>.>>..>>>.........[[...((((((((....>>>>>>>>.))))))))..]].....]]....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<.<.......>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<......<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<......>>...<<<......>>>...>>.>>>....<<<<..<<..<<<<..<<<<<<<<<<<<....>>>>>>.>>>>>>..>>>>.>>....<<<<<<.....>>>>>>........>>>>....>>>.>>>.....>>>>>>>.......>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<.<..<<<....>>>...>>....>>.......>>>>>>>......<.<..<<<<<<..........>>>>>>>...>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<..<...<<<<<<..........................>>>>>>...>..>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))((((..(..((...(.(...((.....(((.(((..((....((.....(..........)...).){))......(((.......(((..((..((...(.((............{...((.....((.(((.....))).))......))........(((((..((....))..)))))(.(((.((((......[[[[[[[.(((....))).....(......).)))))).)...).(}((((..(((.....))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).))...((....)).....)))))).).....(.(((...((.(.}...).).))))).)....).).....((.((((.(..((....))..).))))..))......(.(.(...........))..).........(((.([[....(.((((.....((..]])).......)))))).)))..))..).))))..{......((({....(.(.((...(((.((.....((((.(((((.....(()).....))))).))).)....((((((.........((.........)).........))))))...((.((.((...........(.........).(((....)))............)).))...)).........(....(..(.(((.....]]]]]]].))).)..)...).....))....((..((..(...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)..))...))...)))...)).)....((((.............(.........)..........))))......<...(((.((.(((...(((((((.((.(.......))))))))))...)))...((...}))...))...}.)))))))..((......((((....))))....))....]]].](((((.(((((((..((.((((((..((((.(((((......((........))........(.(((((.(....((((.........((.((..........))).).......))))....(.((....(.((((((....(((.(.(((....)))..(.((......)))....).)))....(((.(.((..((((..((((((.(((((....)))))..))))))..)))).))..(.((((((.....))))))....)..).)))....))).))).....)..)))......).))))))..)).)))).))).(...(((((((......((.....((..(.((....)).)..))....)).......)))))))......(....((((((..........))))))....)..)..))))))....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..((((..(...(((((............................)))))...)..))))..))).)))))))))..)).))))...).))...)..)..(.(((((((....)))))))).>........ Structure of a partial yeast 48S preinitiation complex in closed conformation; 18S rRNA 3jap 3 14 4.9 26212456 32630 aucucucucuaugc .............. .............. Structure of a partial yeast 48S preinitiation complex in closed conformation; mRNA 3jb9 C 105 3.6 RF00020 URS000086853C_4896 26292707 0030627 0000244,0000353,0000395 0005682,0046540,0005730 4896 cgucaaagcacuuugcaaaagcuaacguaucuguuucuugccuuuuaccagaaacagccguuuguaaggugugcuaauuugacuguauaguuuuuguaaucuuuu .<<<<<<<<<<<<<<<<<<...........<<<<<<<<.<.......>.>>>>>>>>...>>>>>>>>>>>>.....>>>>>>...................... (((((((((((((((((((......((...((((((((.(.......).)))))))).)))))))))))))).....)))))).).................... Cryo-EM structure of the yeast spliceosome at 3.6 angstrom resolution; U5 snRNA 3jb9 N 90 3.6 RF00026 URS0000868525_4896 26292707 0030621 0000244,0000353 0005688,0046540 4896 gaucuucggaucacuuuggucaaauugaaacgauacagagaagauuagcauggccccugcacaaggaugacacugcgacauugagagaaa <<<<....>>>>......................................<<...<<<.....>>>....>>.................. ((((....))))......................................((..((((.....)))..).)).................. Cryo-EM structure of the yeast spliceosome at 3.6 angstrom resolution; U6 snRNA 3jb9 Q 13 3.6 URS000086852C_4896 26292707 4896 uuuauacuaacac ............. ............. Cryo-EM structure of the yeast spliceosome at 3.6 angstrom resolution; RNA (5'-R(P*UP*UP*UP*AP*UP*AP*CP*UP*AP*AP*CP*AP*C)-3') 3jb9 P 111 3.6 RF00004 URS0000868541_4896 26292707 0045131 0000348 0005686 4896 auucucucuuugccuuuuggcuuagaucaaguguaguaucuguaucuuguuuuugguuuuuggaaagccucugggcuaugcuuuccucuugcuauugcacuacuggcaagc ...............................................................<<<<<.<.......>.>>>>>...<<<<<<...........>>>>>>. ..................................................................((.(.......).))......((((((...........)))))). Cryo-EM structure of the yeast spliceosome at 3.6 angstrom resolution; U2 snRNA 3jbn A 1608 4.7 RF01960,RF01959,RF00177 URS0000868510_36329 26432834,24913268 0003735 0005840 36329 aaccugguugaucuugccaguagucauaugcuugucucaaagauuaagccaugcaagugaaaguauauauauauauauguagaaacugcgaacggcucauuaaaacaguuauagucuacuugacauuuauaaggauaacuacggaaaagcuguagcuaauacuugcauuauccuuuuggauaaguauuuguuagaaggaauuauaacaaagaaguaacacguaaaguguguaucaaucgaguuucugaccuaucagcuuuugauguuaggguauuggccuaacauggcuaugacggguaacggggaauuagaguucgauuccggagagggagccugagaaauagcuaccacaucuaaggaaggcagcaggcgcguaaauuacccaauucuaaagaagagagguagugacaagaaauaacaaugcaagguuuguauuggaauggugggaauuuaaaaccuucccagaguaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaauuguugcaguuaaaacgcucguaguugaauuucaaagaaucauucuuuuuaaaauccgauuuuguuacuuugaguaaauuagaguguucaaagcaaacaguuaaagcauuguguuugaauacuauagcauggaauaacaaaauugaacaagcuaaaauuuuuuguucuuauuuuggcuuaguuacgauuaauaggaguagcuuggggacauucguauucagaugucagaggugaaauucuuagauuuucuggagacgaacaacugcgaaagcauuugucuaaaauacuuccauuaaucaagaacgaaaguuaagggagugaagacgaucagauaccgucguaaucuuaaccauaaacuaugccgacuagguguuggaugaagugcuuccuucaguaccuuaugagaaaucaaagucuuuggguucuggggcgaguauucgcgcaagcgagaaaguuaaaagaauugacggaagggcaccaccaggcguggagcuugcggcuuaauuugacucaacacggggaaacucacuaguuuaagacauuggauggugaugcauggccguuuuuaguucgugaaugauuugucugguuaauuccgauaacgaacgagaucuuaaccugcuaauuagcggcgaguacacuguacuugcugcuucuuagaggaacauugugugucuaacacaaggaaguuuaaggcaacaacaggucugugauguccuuagaugaacuaggcugcacgcgugcuacacugauauauauaacgaguaaaauaugcuugcauacuuuuccuccgccgaaaggcguagguaaucuuuaucaauauauaucgugauggggauagauuauugcaauuauuaaucuugaacgaggaaugccuaguaagcaugauucaucagauugugcuaacuacgucccugcccuuuguacacaccgcccgucgcuccuaccgauugaaagauaugaugaauuguuuggacaagaaaaauuuuuucuggaaaaaccguaaauccuaucuuuuaaaggaaggagaagucguaacaagguuuccguaggugaaccugcggaaggaucau ...<<<<<.[.((((>>>>><<<<.<<<<<<...<<<...<......<<<.<<<..<<....<<...<<<<<<..>>>>>>...>>.>>......<<........<<<..<<..<<...<<<<........<<.....<<<<<<.....>>>>>>......>>....<<<<<<....>>>>>>...<<<<<<<.<......>.>>>>>>>.......<<<.....>>>....>>>>..>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>..>>>..>....>>>.....<<<<<<<<...>>>>>>>>......<<<<<<.........>>>>>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>>.........<<<((.....<.<<...<<<.<<....<<<<.<....>.>>>>..<<<......>>><<<<<<.<<.......<<...<.......>.<<<<.......<<<.>>>>>>>...>>......>>.>>..>>>>.....<.<<<.<<.<.<<<.<..........>.>>>.>.>>.>>>..>.>>....<<<<<<..<<..<<<<<..<<<.<<<<<<.<...<<<......>>>......>.>>>>>>.>>>......<<<....>>>..>>>>>.>>.>>>.>>>...>>>...>>.>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<<<<<<<<.<<<<..>>>>.>>>>>>>>>>...<<..))>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<<<....<<.>>...<<.<<<..<<<<<<<<.....<<<<<<<<<...>>>...<<<......>>>...>>>>>>....<<<<<.<<<.<<<...<<<<<<<<<<<<...>>>>>>>>>>>>...>>>>>>....<<<<<<.....>>>>>>.......>>>>>.....>>.>>>...>.>>>>>>>.....>>>>>>>...>>.>>>>.>>>.....<<<<<<<<.....<<.<<<.<<<<<..>>>>>.>>.><<<.<<<<....>>>>.>>>....>>.......>>>>>>>>......<....<<<<<<..........>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<<.<<....<<.<<<<<.<<<..<<.<<<<...<<.<<<<<.>>>.>>.>>...>>>>.>>..>>>.>>>>>>.>...>>.>>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>....... ...((((..[.[[[[.))))((((.((((((...(((...((.....(((.(((..((....((...((((((()))))))...))[))......(((.......(((..((..((...((((....[...((.....((.(((.....))).))......))....((((((....))))))...(((((((.(......).))))))).....(](((.....))))...))))..))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)....))).....((((((((...))))))))....(.((((((.........))))))......)..((((([[....(.((((.....((..]])).......))))))))))..))))))))))..[......((([[...(.(.((...(((.((....((((.(....).))))..(((..()..)))((((((.((.......((..((.......)).(((.......(((.))))))....))......)).))..)))).....(((((.(..(.(((.(..........).))).)..).))).)).))...(((((((..((..(((((..(((.((((((.....((........))........)))))).))).......((....))...))))).)).))).)))..))))...)).)....((((((...((...((((.........))))...))))))))......{...(((.((.((((((((((.((((())))).))))))))))...((..]]))...))...].))))))).(((......((((....))))....)))..]]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((((....((.))...((.(((...(.((((((....(((((((((...)))..(.((......)))...)))))).....((((.(((..(((..((((((((((((...))))))))))))..))).)))..(.((((((.....))))))....)..)))).....))).))).....).))))).....)))))))...)).)))).))).(...((((((......(((...(.(((((..))))).)...((..((((....))))..))....)))........))))))......(....((((.(..........)).)))....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(.(((((.((..(.(((.((((.(((..((.((((...(..((((...)).))..)...)))).))..))).)))))).))..)).)))))..).))...)..)..(((((((((....)))))))))}...... Cryo-electron microscopy reconstruction of the Plasmodium falciparum 80S ribosome bound to P-tRNA; 18S ribosomal RNA 3jbn 7 76 4.7 RF00005 URS000080DFF5_562 26432834,24913268 0030533 0006412 562 cgcgggguggagcagccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.....[..)))).(((((.......))))).....(((((..]....)))))))))))..... Cryo-electron microscopy reconstruction of the Plasmodium falciparum 80S ribosome bound to P-tRNA; P-tRNA 3jbn AA 3193 4.7 RF02540,RF02543 URS0000868527_36329 26432834,24913268 0003735 0005840 36329 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Cryo-electron microscopy reconstruction of the Plasmodium falciparum 80S ribosome bound to P-tRNA; 28S ribosomal RNA 3jbn AC 151 4.7 RF00002 URS0000868556_36329 26432834,24913268 0003735 0005840 36329 agcacagucuuaacgauggaugucuugguuccuacagcgaugaaggccgcagcaaaaugcgauacgcaaugaaaauugcagugacugaaucaucagaaugcugaauguaaacuacaccaauucccugggaauagugguacuccuacagaaa ............................................<<<<<<<<<....>>>>.....(.<<<<.....>>..........>>>>..)...>>>....<<.....>><<<<<<<<<<.>>>>>>..>>>>............. ............................................((((((.[[.....))).....(.((((..(..]]..).......))))..)...)))....((.....))((((((((((.))))))..))))............. Cryo-electron microscopy reconstruction of the Plasmodium falciparum 80S ribosome bound to P-tRNA; 5.8S ribosomal RNA 3jbn AB 118 4.7 RF00001 URS000086850E_36329 26432834,24913268 0003735 0005840 36329 gacucguucauacuacaguggauacaccagaucccaucagaacucugaaguuaagcacuguaaggcuuggcuaguacugaggugggagaccgcucgggaacaccaggugaugagucag <<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>.. ((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......(((((..((....)).))))).....)))))))))))))).. Cryo-electron microscopy reconstruction of the Plasmodium falciparum 80S ribosome bound to P-tRNA; 5S ribosomal RNA 3jbo A 1608 5.8 RF01960,RF01959,RF00177 URS0000868510_36329 26432834,24913268 0003735 0005840 36329 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...<<<<<.[.((((>>>>><<<<.<<<<<<...<<<...<......<<<.<<<..<<....<<...<<<<<<..>>>>>>...>>.>>......<<..<.....<<<..<<..<<...<<<<..<.....<<.....<<<<<<.....>>>>>>......>>....<<<<<<....>>>>>>...<<<<<<<.<......>.>>>>>>>..>....<<<.....>>>....>>>>..>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>>>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>..>>>..>....>>>.....<<<<<<<<...>>>>>>>>......<<<<<<.........>>>>>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>>.........<<<((.....<.<<...<<<.<<....<<<<.<....>.>>>>..<<<......>>><<<<<<.<<.......<<...<.......>.<<<<.......<<<.>>>>>>>...>>......>>.>>..>>>>.....<<<<<.<<.<.<<<.<..........>.>>>.>.>>.>>>.>>.>>....<<<<<<..<<..<<<<<..<<<.<<<<<<.<...<<<......>>>......>.>>>>>.>>>>......<<<....>>>..>>>>>.>>.>>>.>>>...>>>...>>.>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<<<<<<<<.<<<<..>>>>.>>>>>>>>>>...<<..))>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<<<....<<.>>...<<.<<<..<<<<<<<<.....<<<<<<<<<...>>>...<<<......>>>...>>>>>>....<<<<<.<<<.<<<...<<<<<<<<<<<<...>>>>>>>>>>>>...>>>>>>....<<<<<<.....>>>>>>.......>>>>>.....>>.>>>...>.>>>>>>>.....>>>>>>>...>>.>>>>.>>>.....<<<<<<<<.....<<.<<<.<<<<<..>>>>>.>>.><<<.<<<<....>>>>.>>>....>>.......>>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<<.<<....<<.<<<<<.<<<..<<.<<<<...<<.<<<<<.>>>.>>.>>...>>>>.>>..>>>.>>>>>>.>...>>.>>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>....... 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Cryo-electron microscopy reconstruction of the Plasmodium falciparum 80S ribosome bound to P/E-tRNA; 18S ribosomal RNA 3jbo 7 75 5.8 RF00005 URS0000868517_562 26432834,24913268 0030533 0006412 562 cgcgggguggagcagccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacc .<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>.... .((((((..((((.....[..))))..((((.......))))......(.(((..]....))).))))))).... Cryo-electron microscopy reconstruction of the Plasmodium falciparum 80S ribosome bound to P/E-tRNA; P/E-tRNA 3jbo AA 3192 5.8 RF02540,RF02543 URS000086852F_36329 26432834,24913268 0003735 0005840 36329 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Cryo-electron microscopy reconstruction of the Plasmodium falciparum 80S ribosome bound to P/E-tRNA; 28S ribosomal RNA 3jbo AC 151 5.8 RF00002 URS0000868556_36329 26432834,24913268 0003735 0005840 36329 agcacagucuuaacgauggaugucuugguuccuacagcgaugaaggccgcagcaaaaugcgauacgcaaugaaaauugcagugacugaaucaucagaaugcugaauguaaacuacaccaauucccugggaauagugguacuccuacagaaa ............................................<<<<<<.((.....>>>.....<.<<<<...<.)).>........>>>>..>...>>>....<<.....>><<<<<<<<<<.>>>>>>..>>>>............. ............................................((((((.[[.....))).....(.((((..((.]].)).......))))..)...)))....((.....))((((((((((.))))))..))))............. Cryo-electron microscopy reconstruction of the Plasmodium falciparum 80S ribosome bound to P/E-tRNA; 5.8S ribosomal RNA 3jbo AB 118 5.8 RF00001 URS000086850E_36329 26432834,24913268 0003735 0005840 36329 gacucguucauacuacaguggauacaccagaucccaucagaacucugaaguuaagcacuguaaggcuuggcuaguacugaggugggagaccgcucgggaacaccaggugaugagucag <<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>.. ((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......(((((..((....)).))))).....)))))))))))))).. Cryo-electron microscopy reconstruction of the Plasmodium falciparum 80S ribosome bound to P/E-tRNA; 5S ribosomal RNA 3jbp A 1608 6.7 RF01960,RF01959,RF00177 URS0000868510_36329 26432834,24913268 0003735 0005840 36329 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Cryo-electron microscopy reconstruction of the Plasmodium falciparum 80S ribosome bound to E-tRNA; 18S ribosomal RNA 3jbp 7 74 6.7 RF00005 URS000035398D_36329 26432834,24913268 0030533 0006412 36329 ggguaauuggcgcaguugguuagcgcgcgggucucauaaucccgaggucgugaguucgauccucacauuaccca .<<<.....<<...........>><.<..<......>..>.>.......<.........>......>>>..... .(.(..(..((...........))(.(..(......)..).)....(...(.......)...).).).)..... Cryo-electron microscopy reconstruction of the Plasmodium falciparum 80S ribosome bound to E-tRNA; E-tRNA 3jbp AA 3193 6.7 RF02540,RF02543 URS0000868527_36329 26432834,24913268 0003735 0005840 36329 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Cryo-electron microscopy reconstruction of the Plasmodium falciparum 80S ribosome bound to E-tRNA; 28S ribosomal RNA 3jbp AC 151 6.7 RF00002 URS0000868556_36329 26432834,24913268 0003735 0005840 36329 agcacagucuuaacgauggaugucuugguuccuacagcgaugaaggccgcagcaaaaugcgauacgcaaugaaaauugcagugacugaaucaucagaaugcugaauguaaacuacaccaauucccugggaauagugguacuccuacagaaa ............................................<<<<<<.((.....>>>.....<.<<<<..<<.)).>>.......>>>>..>...>>>....<<.....>><<<<<<<<<<.>>>>>>..>>>>............. ............................................((((((.[[.....))).....(.((((..((.]].)).......))))..)...)))....((.....))((((((((((.))))))..))))............. Cryo-electron microscopy reconstruction of the Plasmodium falciparum 80S ribosome bound to E-tRNA; 5.8S ribosomal RNA 3jbp AB 118 6.7 RF00001 URS000086850E_36329 26432834,24913268 0003735 0005840 36329 gacucguucauacuacaguggauacaccagaucccaucagaacucugaaguuaagcacuguaaggcuuggcuaguacugaggugggagaccgcucgggaacaccaggugaugagucag <<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>.. ((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......(((((..((....)).))))).....)))))))))))))).. Cryo-electron microscopy reconstruction of the Plasmodium falciparum 80S ribosome bound to E-tRNA; 5S ribosomal RNA 3jbu A 1530 3.64 RF00177,RF01959,RF01960 URS00000ABFE9_83333 26670735 0003735 0005840 83333 ugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggauca ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<...<<<.<<<........>>>.>.>>.>>..>>>>>......<<.......<<<<<<<..<.....<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<...<<....>>.>>>>>.>>>>>>....>.>>>>>>><<<....<<<...<<<<<<.........>>>>>>.>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<.......<<....>>.....>>..>>.>>>>>>..<<<<.......<<<<..>>>>......>>>>...<.<<<<<......<..<<<<<.<.......>.>>>>>..>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<.<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>.>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<.......<<<....>>>.....>>>..))))..].<<<.<<<<<<<.<<.<<<.....<<<<<<<<........<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<...<<<<<<..<....<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<.....>>>>>........>>>>.....>...>>>...>>>.>>>>>...>>>>>>>......>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>........>>>....<<<<<<...........>>>>>>......>>...>>>>>>>>>>..........<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<..<<<<..<<....>>.>>>>.>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>...... ....((((..[.[[[..)))).((((.(((((..((((((.((....(((.((...(((..((.((...((...((........))....)).))..)))))......(((........((((...((....((((((...((.....((((((....))))))......)).......(((....)).)....(((((..((....)))))))..))))))...))..))))..(((.....((...((((.((.......)).)))).)).......)))..((((((((....))))...))))))).(((((............))))).((((....))))....))))).).....(.((........(....)......))).)..))))))..(((.......((((....))))......))).....((.(....(.......(((...........)))........)......))).......((((([[[...(((((.....(..]]].).......))))))))))..)))))))))..........((([[.....((((...(.(....((((.(((((((.(.......((((((.....)))))).....).)))))..)))))).....(((((.(((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))..))))..)).)...))))....(((.((...((...((((.........))))...)))).)))......{...((((((...((((.((((((.....)))))).))))....((..]])).....)))))).))).(((.......(((....))).....)))...]]].](((((.(((((((.((..((.....(((..(((((......((........))...........((((((..(.....(.(((..(((((((....)))))))....(....)...))).)...).(..(((...(((((..(....(.(((((((....)))...(((......)))...))).)).....((((.((((.((...((...((.....)).))....)).)))).....(((((.....)))))........)))).....)...)))...)).)).))....))))).)...)).)))..))).(...(((((.......(((..((....((....))....))....))).......)))))......(....(((((((........)))))))....)..).....)).....(((((.(.........).)))))......))...)))))))))).))....(...(.(.((((.(((..((((.(((((((....((((((.((((..((....)).))))))))))...))))))).))))..))).))))..).)....).....(((((.(((....))).)))))}..... Mechanisms of Ribosome Stalling by SecM at Multiple Elongation Steps; 16S rRNA 3jbu X 11 3.64 26670735 83333 gcuggcccuca ........... ........... Mechanisms of Ribosome Stalling by SecM at Multiple Elongation Steps; mRNA 3jbu a 118 3.64 RF00001 URS0000049E57_83333 26670735 0003735 0005840 83333 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (.(((((.(.....((((((.(....((((((....(.....)....)))..)))...).)))).)).((.......((((((((...)))))))).......))...).))))).). Mechanisms of Ribosome Stalling by SecM at Multiple Elongation Steps; 5S rRNA 3jbu b 2903 3.64 RF02540,RF02541 URS00004B0F34_83333 26670735 0003735 0005840 83333 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((((((((......((((..((((.....(((..(((((..((((((......((((((.[..[[[.)))......(((((...(((]]]..]).)).......)))))....)))....(((....)))(((((.(....).))))).((((.(((...........))).)))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((..(.(((.((.((....(((((......)))))[[(...).(((.....]])))....))...)).))).)..)))...))))...)....((.(.(((..[......))).).))......(((((].[[[[)))))..)))......)).))..))).))...............((....))....))......(..((((.....))))............)).....))))..)))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((.(..(((...((.....))...)))...((....))..((((.....)))).....).)))))))))))..((.(...((((((.....((((((..((.(((....((((((......))))))....[)))...(((.(((((........))))))))..).)..)))))).(.((.......))...)..))))))......).))..((((((....(((((....))))).(((((((.(..(.(((((((.....(((...(((.((((...(((.(.........).).))...)))).)))..)).).....)))))))..).)..)))))).)...((((((((..........))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(.(((..(((.....{...(.....(..(((.....[...)))..).......(..(((....].))))...).....)))..))).).))...........]]].)...))))))))))...)))))))((.(.((........)).).))....))))))(.(((((....((.......((..(((....)))..))....))...)))))..).....))))))(......((.....((((((.......))))))((((.....(((..((..(((((((...((.....)).))))))....[[(((..((.(.(.(...(((....)))...).)..)))...((((..........))))]](((.((((((.((...((((....((((..(((..(((((((((((....{{....))))))((..((......((((((.(..(.((.....)))..).)))..)))...[..))...))(..(.(((....))).)...))))))...)))...))))(..).....))))...)).....)))))).))).))).))).....((......)).)))..(((.......)))..))))..((((....((((((.(.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......((((((.((.].((.........))...(((((((.....(........).......))))))).}.(((.(((..(((((((.............(((((..((....))...)))))...........)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....))..)))))).)..))).).)))))).)))))).....)).{..(((((.....]}.)))))..((((((((.((..((.......(.(.((((((..(((((.(((.((((..((((((.((((.................((.............((....((....))....))....................))........)))).))))))...(((.((((((.....))))))))).....)))).)))..)))))..(((......[)))((((((..........]))))))([.(...(((((((.(.(((((.........)))))...)...][.[[[......)))))))...((((..((((..{.))))..)))).(((....))).).]]].].....((.((((.((..]]]]..)))))).)).....)}......))))..))).)........((((.(.((((((...((.......))...))))))...)))).)..........((.((((((..((.(((............)))...)).(((((.....))))).....)))))..)...))........((..(((....)))...))....))...))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...((((.((((((.}}.))))))...))))...)))).)))))....((....((((.....}.......))))....))..))))..]....)))))))(.(((((.....)))))(....((..(((.(.......).)))....(((.((((..((....(((((....)))))...))...))))..))).....))..).))))))))). Mechanisms of Ribosome Stalling by SecM at Multiple Elongation Steps; 23S rRNA 3jbu v 76 3.64 RF00005 URS00008FED32_83333 26670735 0030533 0006412 83333 cggcacguagcgcagccgguagcgcaccgucaugccgugucgggggucggagguucaaauccucucgugccgacca <<<<<<...<<<<........>>>>.<<<.<<.....>>.>>>.......<<<.......>>>...>>>>>>.... .(.((((..((((........)))).(((...........)))......((((.......))).))))).)..... Mechanisms of Ribosome Stalling by SecM at Multiple Elongation Steps; glycine-tRNA 3jbv A 1530 3.32 RF00177,RF01959,RF01960 URS00000ABFE9_83333 26670735 0003735 0005840 83333 ugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggauca ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<....<<<..<<........>>..>.>>..>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<...<<.....<<<<<......>>>>>......>>.......<<......>>....<<<<<...<<....>>.>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<.<<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<......<<....>>....>>>..>>.>>>>>>..<<<<.......<<<....>>>......>>>>...<.<<<<<......<<...<<<...........>>>....>>.......>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<.......>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<.<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<......<<<<....>>>>......<<....>>...>>>>.>>.<<<.<<...<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<..<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>.........>>>.........>>>...>>>.>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>.>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<.<..<<<<<<.<<<<..<<....>>.>>>>>>>>>>..>>>>>>>>>>>>>..>>>.>>>>..>.>>..........<<<<<<<<....>>>>>>>>....... ....((((..[.[[[..)))).((.(.(((((....(((.(((....(((.(((..(((..((......(((((..(.......).))).)).....)))))......(((.......((.(((..((...(((((((....(......(((((....))))).......)........((......))......((....((....))..))...)))))))..)).))).)).(((....(((..((.(((((.......)))).))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(..(.......((....)).....).).))..)))....((((......((((....)))).....))))...(.(((((...(.........(.(.......))...........)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))).))..........((([[...(.((((...(((.(((.(((.((((((((((......(((((.......)))))....))))))))..))))).)))..((((.((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).).)))..))))...))))....((((((...((...((((.........))))...))))))))..........((((((..(((((((((.(.......).)))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((.(.((..((.((..((((((((((......((........))..........(((((((..(...((((((...(.(((((....))))).)...((....))...)))).))).((.(((...((.(((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....))))))).....(((((.....)))))........)))).....).).))....)).)))))....)))))))...)).)))))))).(...(((((.......(((..((....((....))....))....))).......)))))......(....(((((((........)))))))....)..)..)).)).....(((((((.........)))))))......))...).)))))))).))..(.(..((.(.((((.(((..(((((.((((((....((((((.((((..((....)).))))))))))...)))))).)))))..))).))))..).))...)..)...(.((((((....))))))..)...... Mechanisms of Ribosome Stalling by SecM at Multiple Elongation Steps; RNA (1530-MER) 3jbv V 76 3.32 RF00005 URS00008FED3A_83333 26670735 0030533 0006412 83333 gcccggauagcucagucgguagagcaggggauuaggaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (.(((((..((((........))))..((...........))......((.((.......)).))))))).).... Mechanisms of Ribosome Stalling by SecM at Multiple Elongation Steps; RNA (76-MER) 3jbv W 75 3.32 RF00005 URS00008FED25_83333 26670735 0030533 0006412 83333 cggcacguagcgcagcugguagcgcaccgucaugccgugucgggggucggagguucaaauccucucgugccgaca .<....<..<<<<........>>>>.<<<.<.......>.>.>>......<<<.......>>>.>....>..... .(.(.....(((..........))).(...(.......)....).......(.........)......).).... Mechanisms of Ribosome Stalling by SecM at Multiple Elongation Steps; RNA (75-MER) 3jbv X 11 3.32 URS00008FED4E_83333 26670735 83333 cuggcccucaa ........... ........... Mechanisms of Ribosome Stalling by SecM at Multiple Elongation Steps; RNA (5'-R(P*CP*UP*GP*GP*CP*CP*CP*UP*CP*AP*A)-3') 3jbv a 117 3.32 RF00001 URS0000049E57_83333 26670735 0003735 0005840 83333 ccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>.. ((((((((.....((.(((((....(((((.....(.....).....))..)))...)))))..)).((.......((.(((((...))))).)).......))...)))))))).. Mechanisms of Ribosome Stalling by SecM at Multiple Elongation Steps; RNA (118-MER) 3jbv b 2903 3.32 RF02540,RF02541 URS00004B0F34_83333 26670735 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<<..>>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<....<.<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>..>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<......<<<.......>>>.......>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<....<..<<<<.......>>>>..>..........<<<......>>>...>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<........>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<..<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<..<<.....>>.>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<......>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<<.<<....>>..>>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<..<<<<<<<<<<<..<<<............<<.............<<<<<<........>>>>>>....................>>...>>.>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>.....>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<.)))..>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<<...>>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((.(((((.....(((..(((((.(((((((......((((((.[..[[[.)))......(((((...(((]]]..]).)).......)))))....)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......((((((.((.(((.((....(((((......)))))[[(...).(((.....]])))....))...))).)).))))))...))))...).....(((.(((..[......))).))).......((.((].[[[[)).))..)))......)).))).))).))...............((....))....))......(..((((.....))))............)).....))))).)))).....(.((.(..(((((......)))))..).)).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....(((((((.((.((((...((((((......))))))...).)))...(((.(((((........))))))))..).).))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).(((((((.(..(.(((((((.....(((...(((.((((...(.(.(.........).).)....)))).)))..)).).....)))))))..).)..)))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.(((((......(.....((..(.(((..(((.....{..((........(((.........)))..............((......)).....))....)))..))).).))...........]]].)....)))))))))...)))))))(((((............)))))....))))))(.(((((....((......(((..(((....)))..)))...))...)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((..((.(.(.(...(((....)))...).)..)))...((((..........))))]](((.(((((((((...((((....((((..(((..(((((((((((....{{{...))))))((..((......((((((((..(.((.....)))..)))))..)))......))...))(..(.(........).)...))))))...)))...))))(..).....))))...))....))))))).))).))).))).....((......)).)))).(((.......)))..))))..((((....((((((.(.((..(....(.......(((((....(.[..).....)))))((((((.....(((...((((.....))))...)))...))))))(...).......((((((.((...((.........))...(((((((.....(.(....).).......))))))).].(((.(((..(.(((((.............(((((..((....))...)))))...........)))))...))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....))..)))))).)..))).).)))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((.(....(.(..........(.....(.(.......((..............))....).)...............).).)....).)))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...)...][.[[[......)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..)))))).......((((.(.((((((...((.......))...))))))...)))).)........((((.((((((..((.(((((........)))))...)).(((((.....))))).....)))))..)...))).).....((.((.(....).).).))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....(((.((((..((....(((((....)))))...))...))))..))).....))..).))))))))). Mechanisms of Ribosome Stalling by SecM at Multiple Elongation Steps; RNA (2903-MER) 3jcd a 1533 3.7 RF00177,RF01959,RF01960 URS000080E246_83333 26809121 0003735 0005840 83333 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggauca .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<......<<<.<<<..<<<..<<.....<<<...<..........>....>>>....>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..........>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<......>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>...>.>>>>>>..<<<<.......<<<....>>>......>>>>...<.<<<<<......<.<<<<<<...........>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<..<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>....<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>.>..........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<.....<<<<<<<....>>>>>>>...<<....>>.....>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>...... .......((((..[.[[[..)))).((.(.(((((..(((((((((....(((.(((..(.(..((.....(.(...................).)....))).)......(((......(((.(((..((...((((.((.(.((.....((((((....))))))......)).).....(((....)))....((((((..........)))))).)).))))..)).))).)))(((......(...(((((...........))))).)........)))..((((((((....))))...))))))).(((((............))))).((.(....).))...)))))).).....(.(((...(.((......))..))))).)).))))))..(((.......((((....))))......))).....(((((...(....(((.((.(.......).)).))).....)....))))).......((((([[[...((..(.....((.]]])).......)..)))))))..)))))).))..........((([[...(.((((...(((..((((.(.(.((((((((......((((((.....))))))....))))))))...)).))))...(((.(((((...((.((((.(...(((((((...((........))......)))))))....).......((....)).)))).))..)))).).))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((.(((((.......))))).)))))...((..]])).....)))))))))).(((......(((......)))....)))...]]]..]((((.(((.(((.((..(((.(..((((...(........((........))........(.(((((((......(.(((.(..(((((((....)))))))...(......)..).)))..)..((.(((...((((((......(((((((((....)))...(((......)))...)))))).....((((.(((((.(...((..(((.....)))))....).)))))..(..(((((.....))))).....)..)))).......).)))...)).)))))....)))))))).....)...)))).(...((((((......(((..((...(((....)))...))....)))......))))))......(.....((.(((........))).)).....)..)..).))).....(((((((.........)))))))......))...))).)))))).)...(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..)).)))))..).))...)..)..(((((((((....)))))))))}..... Structure of Escherichia coli EF4 in posttranslocational ribosomes (Post EF4); 16S ribosomal RNA 3jcd A 2903 3.7 RF02540,RF02541 URS00004B0F34_83333 26809121 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[.<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..))).......].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<..........................>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<.........>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<.<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<.<<<<<<<.<<.....>>>>>>>>>...>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>.....>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.......<<<<<<.<......>..>>>>>>.......>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<<<<<............<<..<.......>...>>...................>>>>>...>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.)))....(((((((...(((]]]..].))).......)))))).).)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((.(......).)))..))))...(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....(.((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))).).(.(((.....)))...)..))))))......).))..((((((....((.((....)).)).((((((((..((((((((((.....(((...(((.((((....(..(.........)...)....)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.((...((...........))...)).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((.(((...((((....((.(..(((...(((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..(.(........).)...)))))....)))...).))(..).....))))...))....).))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(.(((((..(((........(((((...(....)....)))))........))))))))...))))(((((.........)))))........((..........(.(((.......))).)..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).[..(((((......].)))))..((((((((..((.((......((((.((((((..((.((.(((.(((((.(((((((.(((......(............((............(.(............).)...................))...)......)).))))))))...(((.((((((.....)))))))))....))))).)))..)).))..(((......[)))((((((..........]))))))([((...(((((.(...(((((.........))))).....((][.[[[))....).)))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)....))..)).))))))))[...(((((((...((((..((((.((.....(....)....)).)))).(((((...((((...((.((((((((}}}.))))))..)).))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Structure of Escherichia coli EF4 in posttranslocational ribosomes (Post EF4); 23S ribosomal RNA 3jcd B 118 3.7 RF00001 URS0000049E57_83333 26809121 0003735 0005840 83333 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.....<.<<<<<<<<...>>>>>>>>...>...>>...>>>>>>>>>. .((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))).. Structure of Escherichia coli EF4 in posttranslocational ribosomes (Post EF4); 5S ribosomal RNA 3jcd 8 76 3.7 RF00005 URS00005AA258_32630 26809121 0030533 0006412 32630 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).(((((.......))))).....(((((..]....)))))))))))).... Structure of Escherichia coli EF4 in posttranslocational ribosomes (Post EF4); tRNA 3jcd 9 76 3.7 RF00005 URS00005AA258_32630 26809121 0030533 0006412 32630 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>><<<<<..<...>..>>>>.>...<<<<<.......>>>>>>>>>>>>.... (((((((..((((........))))..(((.........))).........((.......))...))))))).... Structure of Escherichia coli EF4 in posttranslocational ribosomes (Post EF4); tRNA 3jce a 1533 3.2 RF00177,RF01959,RF01960 URS000080E246_83333 26809121 0003735 0005840 83333 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggauca .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<.....................>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<......>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<.<.......>>>.>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<<..<<<.....>>>>>.....>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<...<<....>>..>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((...................)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((.(....).))))......)).).....(((....)))....(((.((..((....)))).))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((....((((....))))..)))).)).))))))..((((......((((....)))).....))))..((.(((((...(...(((((((.(.......))).)))).)...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((.((((....(((((....))))).....((....))..))))..))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((..((((((...((..(((.....)))))....))))))...(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...((((((......(((..((...(((....)))...))....)))......))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Structure of Escherichia coli EF4 in pretranslocational ribosomes (Pre EF4); 16S ribosomal RNA 3jce A 2903 3.2 RF02540,RF02541 URS00004B0F34_83333 26809121 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<......>......>>>>>.>...[.....<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))....].]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<..<<<.......>>>...>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<.<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>.>........>>>>...>>.....>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<..<<....>>...>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<..<<<<...........<<<<<.............<<.<<......>>.>>....................>>>>>..>>>>..>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. .(((((((......((((((((((.....(((..(((((((((((((......((((((....[[[.)))....(((((((...(((]]]....))).......)))))).).)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.........[.........))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((.(((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))))))).)))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..(.((.....)).).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...).)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((.(.....(((...(((.((((...((...(.......)....))...)))).)))..)).).....).)))).)))..)))))))).)...((((.(((((......))))).))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((..((..(((.........)))..))......(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((((......))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((.(((((.(((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..((((......))))...))))))...)))...))))(..).....))))...))....).))))).))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((...((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((..((((.((((............................(..((((....))))..)..........................)))).))))..)))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))(.((...(((((((...(((((.........))))).....((.[.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..)))))).......((((.(.((((((...((.......))...))))))...)))).)........((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).)))))))).. Structure of Escherichia coli EF4 in pretranslocational ribosomes (Pre EF4); 23 ribosomal RNA 3jce B 118 3.2 RF00001 URS0000049E57_83333 26809121 0003735 0005840 83333 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (.(((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))).). Structure of Escherichia coli EF4 in pretranslocational ribosomes (Pre EF4); 5S ribosomal RNA 3jce 6 76 3.2 RF00005 URS00005AA258_32630 26809121 0030533 0006412 32630 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..))))((((((.......))))).)...(((((..]....)))))))))))).... Structure of Escherichia coli EF4 in pretranslocational ribosomes (Pre EF4); tRNA 3jce 7 15 3.2 26809121 32630 cauauguucaaagaa ............... ............... Structure of Escherichia coli EF4 in pretranslocational ribosomes (Pre EF4); mRNA 3jce 8 77 3.2 RF00005 URS000041AF00_32630 26809121 0030533 0006412 32630 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Structure of Escherichia coli EF4 in pretranslocational ribosomes (Pre EF4); tRNA 3jce 9 76 3.2 RF00005 URS00005AA258_32630 26809121 0030533 0006412 32630 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<...<<<<........>>>>.<<<<<.......>>>>>.....<<<<.........>>>>.>>>>>>.... ..(((......((........))....(((.........)))......(((((.......)))))..)).)..... Structure of Escherichia coli EF4 in pretranslocational ribosomes (Pre EF4); tRNA 3jcj 0 118 3.7 RF00001 URS0000366A67_562 26973877 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<........<<<<<<<...>>>>>>>........>>...>>>>>>>>>. (((((((((.....((((((((....(((.(((...(.....)...)))...)))...)))))).)).((.......((((((((...)))))))).......))...))))))))). Structures of ribosome-bound initiation factor 2 reveal the mechanism of subunit association; 5S ribosomal RNA 3jcj A 2854 3.7 RF02540,RF02541 URS00004B0F34_562 26973877 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauggaaguguggacgccagucugcauggcuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<......>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<.<....<<<...<<<.<<<<...<<<<<<.>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<......<.<<<<<......<<<<.......>>>>.............<<<......>>>..>>>>>.>..>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>...<<<<........>>>>.))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>.>........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<..<<...............<<<<<....<<..>>.....>>>>><<<<<<.....<<<...<<<.<....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.......<<<<<..<......>...>>>>>.......>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>.....>>..>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.((......<<<<.((<<<<..<<<<<.<<<.<<<<<.<<<<<<<<.<<...............<<......>>..............>>.>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<....((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))........<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..))>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....))..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<....<<<...<<<<<<<<<<.)))..>>>>>..>>>>>...>>>..>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<.........>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((.(((((......((((((((((.....(((..((((((((((((.......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........)))))))))..)...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..(((((((..(.....(((...(((.((((...(((.(...).).))...)))).)))..)).).....)..))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.((...((...........))...)).....(....(......)..).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((...((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))(...((((...((((((((((((.((.....))))))))))..))))..[))))....)(..((((......))))...))))))...)))...))))(..).....))))...))....))))))))))).)))..)).....((......)).)))).((((.....))))..))))..((((....(((((((..((..(....(.......(((((....(.{..).....)))))((((((.....(((...((..(..)]..))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..)))..))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((((((..(.......................................)..))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))(.((...(((((((...(((((.........))))).....((....[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]........((.((((.((..]]]]..)))))).)).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....(.((.....}.......)).)....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).)))))).)). Structures of ribosome-bound initiation factor 2 reveal the mechanism of subunit association; 23S ribosomal RNA 3jcj g 1539 3.7 RF00177,RF01959,RF01960 URS00000ABFE9_562 26973877 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<......>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<....<....>..>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<.<<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<....<<<......>>>.......>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<.......<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>..<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<...<<<.....>>>.>.....>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<....<<<....>>>....>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((.(.....)))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((...(....).)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((.(.......).)))))).....)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))...........(([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))..(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(.(((((..(((((((....)))))))....(....)...)))))..)).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((....(..(((.....)))).....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Structures of ribosome-bound initiation factor 2 reveal the mechanism of subunit association; 16S ribosomal RNA 3jcj v 77 3.7 RF00005 URS00001BBAFC_562 26973877 0030533 0006412 562 cgcggggnggagcagccuggnagcucgucgggcucauaacccgaagaucgucggnucaaauccggcccccgcaacca ..<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>...... ..(((((..((((.........)))).(((((.......))))).....(((((.......))))))))))...... Structures of ribosome-bound initiation factor 2 reveal the mechanism of subunit association; tRNA 3jcm C 20 3.8 26743623 32630 aaaaaauuaagguauguauu .................... .................... Cryo-EM structure of the spliceosomal U4/U6.U5 tri-snRNP; pre-mRNA 3jcm D 45 3.8 RF00026 URS00006184A9_559292 26743623 0030621 0000244,0000353 0005688,0046540 559292 aauacagagaucagcaguuccccugcauaaggaugaaccguguuu ............................................. ............................................. Cryo-EM structure of the spliceosomal U4/U6.U5 tri-snRNP; SNR6 snRNA 3jcm E 85 3.8 RF00015 URS00001143F5_559292 26743623 0017070 0000244,0000353 0005687,0046540 559292 auccuuaugcacgggaaauacgcauaucagugaggauucguccgagauuguguuuuugcugguuagggaauuuuuggaauaccuu ...................<<<<<.<<<.....<<<....>>>..>>>>>>>>................................ ...................(((((.(((.....(((....)))..))))))))................................ Cryo-EM structure of the spliceosomal U4/U6.U5 tri-snRNP; SNR14 snRNA 3jcm F 113 3.8 RF00020 URS000053F313_559292 26743623 0000244,0000353 0005682,0046540 559292 ggaggucaacaucaagaacugugggcgccuauagaacuuauaacgaacaugguucuugccuuuuaccagaaccauccggguguugucuccauccauauuuuuuggaacuuuuc <<<<<.<<<<<<.<<<..<<<<<<<..>>>>>>>..>>>.........<<<<<<<<...........>>>>>>>>....>>>>>>>>>>>....................... ((((..(((((.((((..((.(.((())).).))..)))....((...((((((((.(.......).)))))))).))).))))).))))....................... Cryo-EM structure of the spliceosomal U4/U6.U5 tri-snRNP; SNR7-L snRNA 3jcn A 2897 4.6 RF02540,RF02541 URS00004B0F34_562 26973877 0003735 0005840 562 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<<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<.>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<...........>>...>>........<<........>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<..<......>..>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>.>........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<..<<....>>...>>>>>..>....>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<.........>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))((((((......)))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((.(......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...).))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[...(........)...((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...).)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((((...))).))...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((..((..(.............)..))......(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((..........))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((...(((...(((....)))...)))...)))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..(((....((((((((((((.((.....))))))))))..))))..[.)))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((...((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..))))).((((.........)))).........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((((.(.........(((((...((.......(((((((....)))))))....)).............)))))).)))).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))(.((...(((((((...(((((.........))))).....((.[.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..)))))).......((((.(.((((((...((.......))...))))))...)))).)........((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Structures of ribosome-bound initiation factor 2 reveal the mechanism of subunit association: Initiation Complex I; 23S ribosomal RNA 3jcn B 119 4.6 RF00001 URS0000049E57_562 26973877 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<........<<<<<<<...>>>>>>>........>>...>>>>>>>>>> ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))) Structures of ribosome-bound initiation factor 2 reveal the mechanism of subunit association: Initiation Complex I; 5S ribosomal RNA 3jcn a 1539 4.6 RF00177,RF01959,RF01960 URS00000ABFE9_562 26973877 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<<....>>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<.....>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<.<......<<........>>..........<<<<<<<.......<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>..<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<...<<<.....>>>.>.....>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>..>>>>>>>>.....<<<<<<<.....<<<..<....<<<....>>>....>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((((((......)))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..........)))))).)))))))..)).)))))))((((...(((..((((((((.......))))))))))).....))))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((((.......)))))))).....)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))...((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))...)))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((....(((((....)))))......(....)...))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....))))))).....(((((.....)))))........)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Structures of ribosome-bound initiation factor 2 reveal the mechanism of subunit association: Initiation Complex I; 16S ribosomal RNA 3jcn v 77 4.6 RF00005 URS00001BBAFC_562 26973877 0030533 0006412 562 cgcggggnggagcagccuggnagcucgucgggcucauaacccgaagaucgucggnucaaauccggcccccgcaacca ..<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>...... ...((((..((((.........)))).(((((.......))))).....(((((.......)))))))))....... Structures of ribosome-bound initiation factor 2 reveal the mechanism of subunit association: Initiation Complex I; tRNA 3jcs 1 1554 2.8 RF02543,RF02540 URS00003CF284_5661 27373148 0003735 0005840 5661 agaccugaguguggcaggacuacccgccgaacunaagcauauuacncagcggaggaaaagaaaacaaccgugauucucucagugagcggcgagcgaagagggaacgaacucguugccgaaucgggucuuacaaggccuugaguuguggcacaaauaucauuucgugguuggugcaggaguggcgaaauucaagcgcaaagcaaacccguugcugaauacaacccuucaugugaguauugagccaaagaagguguuagcccauugagccauaaaccugagcgccucaugaacuguauuaagcgaguagcacuguuugggaaugcagugucaaguuggcagguauuugucugccaaaguuaaauacagaguaggaagaccgauagcgaacaaguagcgugagcgaaaguuugaaaagcacuuuggaaagagagugaaauagaaccugaagucgugacaaagacaauggaaguaccuccauuucaacggccagaaccagcccuacugcauuauccugucggccggcgggcaacgaagugcaagaauuuugggucuuggugaaugcuccauggcgauggaaauggggugcccccacccgucuuganacncggaccaaggagunaaacagacgcgcaagggaggagauauccaguacuucucucguacugaaagggagaugcaaugcaucuguggugugcacacgucaaauccguuugauuugcccaacaccgaccggcccuccguggguugcguuggagugugccngnuuggacccnaaagguggugaacuaugccugaacaaggugaagcccgggaacccagguggaggccuguagcgaugcugncgugcaaaucgcucguaugauuugggunucgnagcgaaagacucaucgaaccaccuaguagcugguucacaucgaaguuucccucaggauagcuggugcuaguagaaguauugugcgguaaagcaugauuagagguugguguuaauaucgaccuauucucacuuuaaaugugcaaacaaaccugccuuagccugcaaggccggaaagaaauuagaggcaccaagugggccuucuucgguaagcggagcaggcgaugcggaaugaaccgcuuagggauauguggcgucaaaacuuaugggcucauucgauacgugaaaaggguguugguggauaacaaauccaccggccccgaaaauggaugacgcuuaagcccaauuagugauugcccauuauuccuuugguaagggcggaaacuuggagaaaguguagcccuuccgauguagauguggccuggagguuaggacgaagcuuauggcgugagccuaagauggaccggccucuagugcanaunuugguuggcgunncaaagaucuaacggagacguuggauacuggagcggggaaggauuucgugccaacggcacucguacacganuuguucggaaacugagcacaacguuauaucguuuuguuaggaaagugaaggugugggccauaacugaaaaggggcaacagagaaccuggguuauauuccaaaaagaaauugcaugugg ......................<<<<<......<<....>>.......>>>>.>...<.....<<....>>..<<<<<<......<<.....>>....>>>>>>...<<<...<<<<...<<<<<<<......>>>>>.>>.....>>>>....<..<<.<<<<.<...<<<<..<<.<<<<<.......<..........<......<..........>.....>..........>............<<.......>>.....>>>>>...>>....>>>>.>.>>>>.>>.>...........<<<<<<<........>>>>>>>......<<<<<........>>>>>..>>>....>...............................<<....>>................<<<<....>>>>..................................<<<..<<<<<<.<<<<<.......<....<.<<..............<<<..........>>>.................>>.>........<....>.......>......>>>>>>>>>>>..>>>.<<<<........>>>><<<<<<....<<<<<<<.<<<<<..<<<.<<<<.<<<...>>>>>.>>>>>...<<....>>.....<.....>.....<<<.......<............>........>>>..<<<<<<<.<.......>.>>>>>.>>....>>>>>.>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<.<<<..>>>.>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>...<<<<<....<.<<<....>>>.><<<<<<<<<.....<<.<.<<<<<<<...<<<..<<<....<<<<<<<<<<..>>>>>>>>>>....>>>>>>....>>>>>>>.....<<.<<<...<<..>>..>>>.>>......>>>...>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>...<<<<..[...>>>>..<<<<<<<...<<<(((........<<<<<......<....]......<<...<<<<<<<<<.....>>>>>>>>>..>>..........))).>....>>>>>..........>>>...>>>>>>><<<<.<<<<<......................>>>>>>>>>....>>>>>....<<<<<<<<........<<<<..<<<....>>>.>>>.>.....>>>>>>>>........>>>>>>..............<<<<<<<....>>>>>>>....................<<<<<....<<.....>>..>>>>>....<<..........<<.<<<<<......>>>>...............<<<<.......>>..>>......>.>>..........<<<..........>....>>.>>.......... ......................(((((......(...[..).......)))).).........((....))...((((.......((.]...)).....))))....((((..((((..(((((((........)))).))....)))))...((...(.((.......((.((.((.(((((....([.(............(....(..........)....)...........).)..........((....]..)).....)))))...))...)).)).....)).)..)).....)....(((((((........)))))))......(((((........)))))..)))....................................((....)).............(..((((....))))............)......................((..((((((.(((((............(.(...........(...(((..(....)..)))......)............))............................)))))))))))..))..((((........))))((((((....(((((((.(((((..(((...((.((.....))))...)))...((....)).....(.....)......((...(...(..(.......).)...)....))...((((.((...........)).)).))....))))).)))))))..((.(...((((((.....(((((((((..((.(...(((.((....)).)))...)..))...(((..((.((........)))).)))....))))))))).(.((.......))...)..))))))......).))...(((((....(.(((....))).)(((((((((.....((.(.((((.(....(((...((....(((((((.((())).)))))))....)).))).....).)))).....((.((((..(....).)))).))......)))...))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((....(([[[...(..(.(((((......(...........((.....(...(((.....)))...)....))..........]]].)....)))))))........))....)))))))((((.(((((......................)))))))))....)))))....((((((((.(......((((..(((....))).))).)...).))))))))........))))))..............(((((((....)))))))....................(((((....((.....))..)))))....((......(...((.(.(((......)))...................((.(..)))...........).))....).....((((........))....)).)).......... 2.8 Angstrom cryo-EM structure of the large ribosomal subunit from the eukaryotic parasite Leishmania; 26S alpha ribosomal RNA 3jcs 2 1119 2.8 RF02543,RF02540 URS0000A76389_5661 27373148 0003735 0005840 5661 cccaacugcagaccguacucaucaccgcaucagguccccaagcauagaaugcucugguacauagagaaanguacacucagggaagucggcaaaauagaugcguaaguucgcaagaagcauuggcucugagggcaauugccacucagaacugcuuacggcggggaauccaacugunuaauuaaaacauagguuugugaugcauccaagugguguauaucgcaaacugauuucugccnagugcucugaaugucaacgugacgagauucaccgacgcgcggguaaacggcgggagacucucuuaagguagccaanugccucnucuuccaauuagagacgcgnaugaauggauuaaugannuucccucugunccgaguuncuaucuagcgaaacgacagucaagggaacggacuugnagggcuaagcggngaaagaagacccunnugaguuugacnccagucuggcucugugcggcgacaucugagguguaguauagguggaagcgcaagcgcaaaugaaauaccaccacucggaaguugcuucacuuaucgaaugaagagaccaauggguuuagcguagucuggcuaugcaccgucuagguuugggaguaauuuuauggcggggugugcuugggcgugacucguggguacccaaccgugcuguaaacugaaccaacgggauugccucgugcaguuccgggucuuguuucgagacaucugccagauggggaguuuggcugcggcuaucuguuacacgacaacgcaggnnuccuaaggcgagcucagugggaacaaucucacguagaacacaagcguaaaagcuugcuugauuaacgauunccaguangaaucgagacugcgaaagcaaggccngcgauccuuugcgaugaacaaaucauaccanaggugucagaauaauuacnacagngauaacuggcuuguggcggccaagcgauagcgacgucgcuuuuugauccuucgaugucggnucuuccuaaccuagcgccgcagaagacgcuaaggguuggauuguucacccacugacagggaacgugagcuggguuuagancgucgngagacagguugguuuuacccuacuuagcuggaaauugcgagaaaaaga ........................<<......>>......<<<<.....>>>>........<<<<....<<<<.<<<<.<<...............<<<<<.....<..>......>>>>><<.<<<<<<.<......>..>>>>>>.>>..........<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.....<<....<<<<......>>>>....>>..>>>>..>>>>>...................<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>>.>>>>............<<<<<........>>>>>..<<<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<...<<<.<<<<<<.<<<.................................................>>>.>>>>>>.>>>...<<<<<.....<<<.....<<.....<<<<<<<...>>>>>>>....>>.....<...<..................<<<<<<..>>>>>>.................>..>................<<<<<<<<.......>>>>>>>>..>>>...>>>>>.......>>>>>>>..>>>>>..<<<....>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<....>>>>>>.....<<......>>....>>>>>>>...<<..<<<<<<.......>>>>>>.>>.<<<....>>>.>>........<<<<<<..<<<.......>>>..>>>>>>.........>>>>..>>>>>>.......<<.<...<.<.<.....<....>.....>.>.>....>.>.>.......<<<<<.<<<<<<..<<<<<<<.<......>.>>>>..>>>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>>>................... ........................((......))......((((.....))))........((((....((((.((((.((..(....(.......(((((....(.[..).....)))))((.((((((...........)))))).))..........(((((((((...((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.....((....((((......))))....))..))))..)))))..(......).........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).)))).........[..(((((......].)))))..(((((((..(((.((......((((.((((((..(((((.(((((((...(((.(((.((.((.(...............................................)).).)).))).)))...(((((.....(((......(......(((((.(.).))))).....)..........(....................((.(..).))...................)...................(((((((.........)))))))..)))...))))).......)))))))..)))))...((...[)).(.((((..........])))).)([((...(((((((.(.(....(....)....)...).((][..[.))....)))))))...(...((((((....{..))))))..).(((....))).)).].].....(((((..(((.......)))..)))))....)}....))))..)))))).......((.(....((....................).)....).).)........((((.((((((..(((((((..........))))..))).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))....))..))).)))))))................... 2.8 Angstrom cryo-EM structure of the large ribosomal subunit from the eukaryotic parasite Leishmania; 26S delta ribosomal RNA 3jcs 3 184 2.8 URS00005C6F67_5661 27373148 5661 gugguaaugcgauugccagguaacaaaucaauccucccacggugagcuuucuuucaccauaauccaucuccggcuuugcuggggcuugggccuuuuuacuucucgcguuguucgggggcucaagauugaaaaaugcagcucucguacuguuuguugugaguucuauuaaagcaaaaaccugggg <<<....>>>.....<<<<<<....<...<.<<.<..<<.<<<<<<......>>>>>><...<<.<...<............>.<<<<<<<<<<<......<.......>...>>>>>>>>>>>.>.>>....>...<........>....>>..>.>.>>....>..........>>>>>>.. (((....))).....((((((....(...(.((....((.((((((......))))))(...((.((.(.............).((((((((((.......(.......)....)))))))))))).))....).................))....)).)....)..........)))))).. 2.8 Angstrom cryo-EM structure of the large ribosomal subunit from the eukaryotic parasite Leishmania; 26S gamma ribosomal RNA 3jcs 4 149 2.8 RF02543,RF02540 URS000037206E_5661 27373148 0003735 0005840 5661 gguaucgugagggaaguaugggguaguaaacucccaugccgugccucuaguuucugggguuugucgaacggcaagugccccgaagccaucgcacggugguucucggcugaacucuaagccagaagccaaucccaagaccagaugcccac <<<<<<.<..<<<<.<<<<<<<<........>>>>>>>><<<<<...<.<<....<<<<<<<<<......>>>>..>>>>>...>>.>..>>>>>.<<<<<.<.<<<<........>>>>.>.>>>>>.>>>>>......>>>>>>... (((((((...(((..(.(((((..........))))).)(((((...(.((....((((((((((....)))))..)))))...)).)..))))).((((....(((..........)))....))))..))).....).))))))... 2.8 Angstrom cryo-EM structure of the large ribosomal subunit from the eukaryotic parasite Leishmania; 26S delta ribosomal RNA 3jcs 5 80 2.8 URS0000A76333_5661 27373148 5661 uacgucccucuccaaacgagagaacaugcaugggcuggcaugagcggccuugaggccugaaauuucaugcuagggacaca ...<<<<<<<<<.......>>>>....<<<<<<<..<<<......<..>.....>>>......>>>>>>>..>>>>>... ...(((((((((.......))))....(((((....((.......(())......))........)))))..)))))... 2.8 Angstrom cryo-EM structure of the large ribosomal subunit from the eukaryotic parasite Leishmania; 26S epsilon ribosomal RNA 3jcs 6 61 2.8 URS0000394942_5661 27373148 5661 ucaucgaaucgccaccuacaagacuggagcuugcucccucgaaggcgccaaguauauucau .......<..........................>.......................... .......(.(......................).).......................... 2.8 Angstrom cryo-EM structure of the large ribosomal subunit from the eukaryotic parasite Leishmania; 26S zeta ribosomal RNA 3jcs 7 154 2.8 RF00002 URS0000A76380_5661 27373148 0003735 0005840 5661 aacgugncgcgauggaugacuuggcuuccuauucguugaagaacgcaguaaagugcgauaagugguaucaauugcagaaauuaccaaucuuugaacgcaaacggcgcaugggagaagcuugucauccccgugcaugccauauucucngugucga ........................................<<<<<<<((....>>>>.....<<<<<......))......>>>>>...>>>....<<.....>><<<<<<<.<(.<<..>>>.).>>>>>>>..................... ........................................((((((.[[.....))).....(((((......]]......)))))...)))....((.....))(((((((.(........)...)))))))..................... 2.8 Angstrom cryo-EM structure of the large ribosomal subunit from the eukaryotic parasite Leishmania; 5.8S ribosomal RNA 3jcs 8 119 2.8 RF00001 URS000001EA06_5661 27373148 0003735 0005840 5661 ucgaguacgaccauacuugagugaaaacaccauaucccguccgauuugugaaguuaagcacucaaggcucaguuaguacugaggucagugaugacucgggaacccugagugccguacuc ...<<<<<<......<<<<<<<......<<<<<..............>>>..>>.....>>>>>>><<<<<<......<<<<<..<<....>>.>>>>>.....>>>>>>..>>>>>>. ....(((((.(........((........(.((..............))...).......))....((((((......(((((..((....)).))))).....))))))).))))).. 2.8 Angstrom cryo-EM structure of the large ribosomal subunit from the eukaryotic parasite Leishmania; 5S ribosomal RNA 3jct 1 3058 3.08 RF02540,RF02543 URS000061F377_559292 27251291 0003735 0005840 559292 guuugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaaacuuuaaauauguaagaaguccuuguuugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuugggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggagugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ..........................<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<<.<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((.<<<<<<<)))))..]]]..................................<<....>>...............<<<......>>>..................................<<<<<.<<<<<......<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<..............>>>.>>>.>>....>>>>>>.>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<......>>.><<.<<.<......<<<.<<<<<<<.......................>>>>>...<<<<.<<<....>>>.>>>>.....>>>>>.....>.>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<......<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>....>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<...............>>>>><<.<<<<<<<<<<....>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>.......<<.....<<<..<...<<....<<<<<....>>>.>>...>>.>.>>>.....>><<<.<<.......>.>.>>>.........<<..>>......>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<....>>>>>....(((((..{{{.........[[[[.{{[[[[..<<<<..<<<<<<<<..<<<<<<<<<.....>>>>>>>>>...<<<<<.....<<<.<....<<......>>..................<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>...>>>>......<.<..<<<<<<<<...........>>>>>>>>.....<<<<<<<...<<<<<<.......>>>>>>...................>>>>>>>...<<<..<<<<.......>>>>..>>>.<<<....>>>...>.>.......(((((...(((..>>>>>>>))).)))))..........]]]]..}}]]]]...............<<<<<...<<.......>>...>>>>>..................<<<<...<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>.....>>>>......<<<<<<<....>>>.>>>>........}}}.)))))....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<..<<<.......<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>................>>>..>>>>>..<<<<<<<.............>.....<<<<<<<<<.<<<....<<<<.<..<<<<<......>>>>>..>>>>>...>>>....>>>>.>>>>>.>>>>>>.. ..........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........(((((((.((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))))....)))))))))))...)....(.(((((........))))).).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.(((((......(((((((((((((((((((((((.......(((((((......((((((....)))))).......))))))).....))))).))))))))))........(((....)))....)))))))).....))))).)))))..((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).(((((.((....(....)....))..))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))....))))))))).(.((.......))...)..))))))......).))).((((((.......((....))...((..(........(((.((((((.((.......(......)....).)))))....(((.((((..)))).)))......)))))........).))..((((.((.((.....).))).))))....(((......)))...(((((((...((([[[...(.(((((.......(...........((.((((((((((.....{.(.(((.(.(...((.........))...).).....(...((......)).).))).)...))))))))))))...........]]].).....)))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........((((((........))))))....))....))...(((((........)))))]]((((.((((((((...((((....)))...(.[.((((((...((((.((((((((((((((((((..{{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....))))..)))))))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.((((((((((.(.)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].............(((.....((.....((((....)))).....))..)))...........((.........)..)............(..).......)).))))))).)..))).)))))))..))))))....)).[..(((((..].)))))....(((((..(((.(......(((((.((((((..(((((.(.(.((((..((((((((.......))))))))....((((.....(((.(...((........)).............]...((((((....))))))..))))..))))......)))).).)..)))))......(.(.....(((((...........)))))........(((((((...((((.(.......).))))......(......).....)))))))...(((...................)))(.((....))..).).).......(.(.....((((.]]]]]]))))...).)..........))))..)))))))...............((((...((.......))...))))...................((((..(((((..(.(((((((......))))))..).).(.(.(.....).).).....)))))....))))......(((.(((....)))..)))..a..)..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}}.)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......(((....(((..(....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)..)))....)))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Cryo-em structure of eukaryotic pre-60S ribosomal subunits; RDN25-1 rRNA 3jct 2 158 3.08 RF00002 URS00001BF64E_559292 27251291 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Cryo-em structure of eukaryotic pre-60S ribosomal subunits; RDN58-1 rRNA 3jct 6 65 3.08 URS000013305B_559292 27251291 559292 ccuucucaaacauucuguuugguagugagugauacucuuuggaguuaacuugaaauugccuuaaa ......<<<<<<...>>>>>>.....<<<<...<<<<....>>>>..>>>>.............. .......((((.....)))).....(((((...(((......)))..))))..)........... Cryo-em structure of eukaryotic pre-60S ribosomal subunits; ITS2-1 miscRNA 3jq4 A 2765 3.52 RF02540,RF02541 URS000080DEF1_243230 20080686 0003735 0005840 243230 ggucaagauaguaaggguccacgguggaugcccuggcgcuggagccgaugaaggacgcgauuaccugcgaaaagccccgacgagcuggagauacgcuuugacucggggauguccgaauggggaaacccaccucguaagagguauccgcaaggaugggaacucagggaacugaaacaucucaguaccugaaggagaagaaagagaauucgauuccguuaguagcggcgagcgaacccggaucagcccaaauucaaccccucaagccgaaguggcuggaaagcuacaccucagaaggugagaguccuguaggcgaacgagcgguugacuguaaggucguuguucgugaaacgaugacugaauccgcgcggaccaccgcgcaaggcuaaauacucccagugaccgauagcgcauaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaagagaaccugaaaccguggacuuacaagcagucauggcaccuuaugcguguuauggcgugccuauugaagcaugagccggcgacuuagaccugacgugcgagcuuaaguugaaaaacggaggcggagcgaaagcgaguccgaauagggcggcauuaguacgucgggcuagacucgaaaccaggugagcuaagcaugaccagguugaaacccccgugacagggggcggaggaccgaaccggugccugcugaaacagucucggaugaguuguguuuagagugaaaagcuaaccgaaccuggagauagcuaguucuccccgaaauguauugagguacagccucggauguugaccauguccuguagagcacucacaaggcuaaaaccuuaugaaacuccgaaggggcacgcguuuaguccgggagugaggcugcgagagcuaacuuccguagccgagagggaaacaacccagaccaucagcuaaggucccuaaaugaucgcucagugguuaaggaugugucgucgcauagacagccaggagguuggcuuagaagcagccacccuucaaagagugcguaauagcucacuggucgagugacgaugcgccgaaaaugaucggggcucaagugaucuaccgaagcuauggauucaacucgcgaagcgaguugucugguaggggagcguucaguccgcggagaagccauaccggaaggagugguggagccgacugaagugcggaugccggcaugaguaacgauaaaagaagugagaaucuucuucgccguaaggacaaggguuccuggggaagggucguccgcccagggaaagucgggaccuaaggugaggccgaacggcgcagccgauggacagcaggucaagauuccugcaccgaucauguggagugauggagggacgcauuacgcuauccaaugccaagcuauggcuaugcugguugguacgcucaagggcgaucgggucagaaaaucuaccggucacaugccucagacguaucgggagcuuccucggaagcgaaguuggaaacgcgacggugccaagaaaagcuucuaaacguugaaacaugauugcccguaccgcaaaccgacacagguguccgagugucaaugcacuaaggcgcgcgagagaacccucguuaaggaacuuugcaaucucaccccguaacuucggaagaagggguccccacgcuucgcguggggcgcagugaauaggcccaggcgacuguuuaccaaaaucacagcacucugccaacacgaacaguggacguauagggugugacgccugcccggugccggaaggucaaguggagcggugcaagcugcgaaaugaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaggcguaacgaucugggcgcugucucaacgagggacucggugaaauugaauuggcuguaaagaugcggccuacccguagcaggacgaaaagaccccguggagcuuuacuauagucuggcauugggauucggguuucucugcguaggugggagaaacuggccggucgguggccacccugagaaacuuggauuucuaaccugaaaaaucacuuucggggaccgugcuuggcggguaguuugacuggggcggucgccucccaaaauguaacggaggcgcccaaaggucaccucaagacgguuggaaaucgucuguagagcgcaaagguagaagguggcuugacugcgagacugacacgucgagcagggaggaaacucgggcuuagugaaccggugguaccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagaguccauaucggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgcuacgggcgcaggagaauugaggggaguugcuccuaguacgagaggaccggagugaacggaccgcuggucucccugcugucguaccaacggcacaugcaggguagcuauguccggaacggauaaccgcugaaagcaucuaagcgggaagccagccccaagaugaguucucccacuguucagguaagacucccggaagaccaccggguuaagaggccaggcgugcacgcauagcaauguguucagcggacuggugcucaucagucgaggucuugacca <<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<<....((>>>>.....<<<<<<...<<.))......>>......>>>>>>...>>>....<<<....>>><<<<<....>>>>><<<<....>>>>>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<......<<.....>>.....>>>>...<<<...<.<<<<<<..<<..<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>....>>..>>>>>>.>....<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>..............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<.......>>>>>>>>>>...<.<........>.>.<<<<<<....<<<.<<<<<<<<<....<.....<.....>.....>.....<<....>>...<<......>>..........>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<.....<<<<<......>>>>>......>>>...<<<<.<.<<<......>>>.>>>>>....>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<...<<<<.<<<<<<...<<<...<<<.<<<<......>>>>.>>>..>>.>...>>>>>>.>.>>>..>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<.<.......<<<<<.<<<...................>>>.........<<......>>...>>>>>...>.>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>>..<..<<<<.......>>>>.>.......>>>>>><.<<<<<<<.<<......<<<<<.<<....>>.>>>>>...>>.>>>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<<..>>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<...<<....<<<....<<<<..<<<..<<<<<.<<<<.<<...[[....>>>>>>.<....<.<..<<<..<<<<<<.............>>>>>>.....>>>..>.>...>.......<<.....>.>......>>>>>...>>>...>>>>.........>>>....>>......>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<...>>>>>>>>............<<<<<<<<<..<<...........>>..<<<<<<<.....<<<.....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<....<<<<<....>>>>>....>...>>>>>>>>..>>>>>.<<<<<.......>>>>>.........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<...<<.<<<<......<.<.......<<.<.<..>>..>>....>.>..>>>>.>>...>>>>>>...<<<.<<.......>>..>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>......>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.]].>>>>>>...>>>>>...>>>>.>>>>>....<<....<<<<<...........>>>>>....>>..>>>>.......>>>>>>>..............<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>>>. ((((((((......((((((((((.....(((..(((.((((((((......((((((.[[..[[.))).....((((((...((.]]..]]..))......))))))...)))....(((....)))(((((....))))).(((....))).))...((((((.....(...[..)......))))).).........((....))...((((......((.]...)).....))))...(((.....((((((..((..(((...(((((......)))))[[(...).(((.....]])))...)))....))..))))))......(((((((((.......)))))))))......(((((..[[[[)))))..)))......)).)))).).))..............((....))....))......(..((((....))))............)).....)))))))))).......((((((((((.......)))))))))).[.(.(........).).((((((....(((.((((((((((...(.....(.....).....).....((....))....(......)..........)))))))))))))..((.(...((((((.....(((((((((..((((....(((((......)))))....)[)))...((...(.(((......))).)..))....)))))))))..(((.....)))......))))))......).))..((((((....(((((....)))))(((((((((..(.(((.(((((....(((...(((.((((......)))).)))..)).)....))))).).))..)))))))).))..(((((((.((......)).)))))))....(((......)))...((((.(((...((([[[...(.(((((((....(.....((..((.(((((.(.......(((((.(((..(.(.........).)..))).....(...((......)).).)))).)..).))))).)).))..........]]].)..).))))))))))...)))))))....(((.(((...))).)))........))))))(.(((((((.((.......((((.((....)).))))....)).)))))))..).....))))))(......((.....((((((.......))))))((((....((((..((...((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]](.(((((((...((....(((....(((((.(((..(((((..(((.((...{{....)))))....(.(......((..((((((....(.....)..)))))).....))......).)......(.(((....))).)....)))))...)))..)))))(..).....)))....))......))))))).)))))..)).....((......)).)))).((((......))))..))))..((((....((((((((.((..(....(.......(((((....(....).....)))))((((((((...))))))))(...).......(((((((((.].(...........)...(((((((.....(((.....))).......)))))))..((((.(((..(((((((..(((....(...((.((....)).))...)....))))))))..)))))(.((((.......)))).)........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)..{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(.(.(((((.(.(((.(..(..((((.(....((((......((...(())...))...))))).))))..)..).))).)...((.((((......)))).))....))))).).)..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....((((((..((..]]]]..)).)))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....)...)))))))))))[...(((((((...((((..(((((((...............))))))).(((((...(((....(((((((((((.}}.))))))...)))))....))).)))))....((....((((.............))))....))..))))..]....)))))))..(.(..).)....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))....)))))))). The structure of the complex of the large ribosomal subunit from D. Radiodurans with the antibiotic lankacidin; 23S ribosomal RNA 3jq4 B 118 3.52 RF00001 URS000080DF5C_243230 20080686 0003735 0005840 243230 cccccgugcccauagcacuguggaaccaccccaccccaugccgaacugggucgugaaacacagcagcgccaaugauacucggaccgcagggucccggaaaagucggucagcgcggggg <<<<<<<<<.....<<.<<<<<....<<<<<<<.............>>>>..>>>...>>>>>..>><<<.......<<.<<<<<....>>>>>.>>.......>>>..>>>>>>>>> (((((((((.....((.(((((....((((((...............)))..)))...)))))..))(((.(.....((.(((((....))))).)).....).)))..))))))))) The structure of the complex of the large ribosomal subunit from D. Radiodurans with the antibiotic lankacidin; 5S ribosomal RNA 3kfu M 71 3.0 RF00005 URS00006143B5_300852 20717102 0030533 0006412 300852 uccgcgguagcucagggnagagcagccggcuguuaaccgguaggucgcaggnucgaguccugcccgcggag <<<<<<<..<<<<......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>. (((((((..((((...[..)))).(((((.......))))).....(((((..]....)))))))))))). Crystal structure of the transamidosome; tRNA-Asn 3kfu N 71 3.0 RF00005 URS00006143B5_300852 20717102 0030533 0006412 300852 uccgcgguagcucagggnagagcagccggcuguuaaccgguaggucgcaggnucgaguccugcccgcggag <<<<<<<..<<<<......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>. (((((((..((((...[..)))).(((((.......))))).....(((((..]....)))))))))))). Crystal structure of the transamidosome; tRNA-Asn 3ks8 E 18 2.401 URS000080E139_32630 20018665 32630 agaaggagggagggagga .................. .................. Crystal structure of Reston ebolavirus VP35 RNA binding domain in complex with 18bp dsRNA; 5'-R(*AP*GP*AP*AP*GP*GP*AP*GP*GP*GP*AP*GP*GP*GP*AP*GP*GP*A)-3' 3ks8 F 18 2.401 URS000080E132_32630 20018665 32630 uccucccucccuccuucu .................. .................. Crystal structure of Reston ebolavirus VP35 RNA binding domain in complex with 18bp dsRNA; 5'-R(*UP*CP*CP*UP*CP*CP*CP*UP*CP*CP*CP*UP*CP*CP*UP*UP*CP*U)-3' 3l3c E 13 2.85 URS000080E2F9_1392 19228039 1392 angcgccagaacu ............. ............. Crystal structure of the Bacillus anthracis glmS ribozyme bound to Glc6P; RNA (5'-R(*AP*(A2M)*GP*CP*GP*CP*CP*AP*GP*AP*AP*CP*U)-3') 3l3c P 141 2.85 RF00234 URS000080E011_1392 19228039 0003824 0010468 1392 ngcaccauugcacuccggugccaguugacgaggugggguuuaucgagauuucggcggaugacucccgguuguucaucacaaccgcaagcuuuuacuuaaaucauuaaggugacuuaguggacaaaggugaaagugugauga <<<<<<..........>>>>>>......(((...<<<<<<..)))..............>>>>>><<<<<<...((((>>>>>>...<<<<<<<<<....<<<<<<<<....>>>>>>>.>....>>>>>>>>>.)))).. ((((((..........))))))......[[[...((((((..]]]..............))))))((((((....[[[))))))...((((.(((......(((((((....))))))).......))).)))).]]]... Crystal structure of the Bacillus anthracis glmS ribozyme bound to Glc6P; GLMS RIBOZYME 3l3c F 13 2.85 URS000080E2F9_1392 19228039 1392 angcgccagaacu ............. ............. Crystal structure of the Bacillus anthracis glmS ribozyme bound to Glc6P; RNA (5'-R(*AP*(A2M)*GP*CP*GP*CP*CP*AP*GP*AP*AP*CP*U)-3') 3l3c Q 141 2.85 RF00234 URS000080E011_1392 19228039 0003824 0010468 1392 ngcaccauugcacuccggugccaguugacgaggugggguuuaucgagauuucggcggaugacucccgguuguucaucacaaccgcaagcuuuuacuuaaaucauuaaggugacuuaguggacaaaggugaaagugugauga <<<<<<..........>>>>>>......(((...<<<<<<..)))..............>>>>>><<<<<<.((((((>>>>>>...<<<<<<<<<....<<<<<<<<....>>>>>>>.>....>>>>>>>>>.)))))) ((((((..........))))))......[[[...((((((..]]]..............))))))((((((..[[[[[))))))...(((((((((.....(((((((....)))))))......))))))))).]]]]]. Crystal structure of the Bacillus anthracis glmS ribozyme bound to Glc6P; GLMS RIBOZYME 3l3c G 13 2.85 URS000080E2F9_1392 19228039 1392 angcgccagaacu ............. ............. Crystal structure of the Bacillus anthracis glmS ribozyme bound to Glc6P; RNA (5'-R(*AP*(A2M)*GP*CP*GP*CP*CP*AP*GP*AP*AP*CP*U)-3') 3l3c R 141 2.85 RF00234 URS000080E011_1392 19228039 0003824 0010468 1392 ngcaccauugcacuccggugccaguugacgaggugggguuuaucgagauuucggcggaugacucccgguuguucaucacaaccgcaagcuuuuacuuaaaucauuaaggugacuuaguggacaaaggugaaagugugauga <<<<<<..........>>>>>>......(((...<<<<<<..)))..............>>>>>><<<<<<..(((((>>>>>>...<<<<<<<<<....<<<<<<<<....>>>>>>>.>....>>>>>>>>>.))))). ((((((..........))))))......[[[...((((((..]]]..............))))))((((((..[[[[[))))))...(((((((((.....(((((((....)))))))......))))))))).]]]]]. Crystal structure of the Bacillus anthracis glmS ribozyme bound to Glc6P; GLMS RIBOZYME 3l3c H 13 2.85 URS000080E2F9_1392 19228039 1392 angcgccagaacu ............. ............. Crystal structure of the Bacillus anthracis glmS ribozyme bound to Glc6P; RNA (5'-R(*AP*(A2M)*GP*CP*GP*CP*CP*AP*GP*AP*AP*CP*U)-3') 3l3c S 141 2.85 RF00234 URS000080E011_1392 19228039 0003824 0010468 1392 ngcaccauugcacuccggugccaguugacgaggugggguuuaucgagauuucggcggaugacucccgguuguucaucacaaccgcaagcuuuuacuuaaaucauuaaggugacuuaguggacaaaggugaaagugugauga <<<<<<..........>>>>>>......(((...<<<<<<..)))..............>>>>>><<<<<<..(((((>>>>>>...<<<<<<<<<....<<<<<<<<....>>>>>>>.>...>>.>>>>>>>.))))). ((((((..........))))))......[[[....(((((..]]]..............)))))..(((((....[[[)))))....((((..........(((((((....)))))))...........)))).]]]... Crystal structure of the Bacillus anthracis glmS ribozyme bound to Glc6P; GLMS RIBOZYME 3loa A 21 2.299 URS000080E2B2_32630 20215440 32630 ccgcgcccgncacaccacccg ..................... ..................... Crystal Structure Analysis of the RNA construct with two adjacent ligand binding sites of helix h44 in 16S ribosomal RNA; 5'-R(*CP*CP*GP*CP*GP*CP*CP*CP*GP*(5BU)P*CP*AP*CP*AP*CP*CP*AP*CP*CP*CP*G)-3' 3loa B 23 2.299 URS000080DD50_32630 20215440 32630 gggnggugaagucguaacgcggc ....................... ....................... Crystal Structure Analysis of the RNA construct with two adjacent ligand binding sites of helix h44 in 16S ribosomal RNA; 5'-R(*GP*GP*GP*(5BU)P*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*UP*AP*AP*CP*GP*CP*GP*GP*C)-3' 3lrn C 14 2.6 URS000080DFA5_32630 20637642 32630 ngcgcgcgcgcgcc .............. .............. Crystal structure of human RIG-I CTD bound to a 14 bp GC 5' ppp dsRNA; RNA (5'-R(*(GTP)P*GP*CP*GP*CP*GP*CP*GP*CP*GP*CP*GP*CP*C)-3') 3lrn D 14 2.6 URS000080DFA5_32630 20637642 32630 ngcgcgcgcgcgcc .............. .............. Crystal structure of human RIG-I CTD bound to a 14 bp GC 5' ppp dsRNA; RNA (5'-R(*(GTP)P*GP*CP*GP*CP*GP*CP*GP*CP*GP*CP*GP*CP*C)-3') 3lrr C 12 2.15 URS000080DF8A_32630 20637642 32630 nuauauauauau ............ ............ Crystal structure of human RIG-I CTD bound to a 12 bp AU rich 5' ppp dsRNA; RNA (5'-R(*(ATP)P*UP*AP*UP*AP*UP*AP*UP*AP*UP*AP*U)-3') 3lrr D 12 2.15 URS000080DF8A_32630 20637642 32630 nuauauauauau ............ ............ Crystal structure of human RIG-I CTD bound to a 12 bp AU rich 5' ppp dsRNA; RNA (5'-R(*(ATP)P*UP*AP*UP*AP*UP*AP*UP*AP*UP*AP*U)-3') 3lwo D 58 2.855 RF02796 URS000080DEB8_32630 20615421 0006396 32630 gggccacggaaaccgcgcgcggugaucaaugagccgcguucgcucccguggcccacaa <<<<<<<<<.......<<<<<<<.........>>>>>>>......>>>>>>>>>.... (((((((((.......(((((((.........)))))))......))))))))).... Structure of H/ACA RNP bound to a substrate RNA containing 5BrU; H/ACA RNA 3lwo E 13 2.855 URS000080DF79_32630 20615421 32630 gagcgngcgguuu ............. ............. Structure of H/ACA RNP bound to a substrate RNA containing 5BrU; 5'-R(*GP*AP*GP*CP*GP*(5BU)P*GP*CP*GP*GP*UP*UP*U)-3' 3lwp D 58 2.5 RF02796 URS000080DEB8_32630 20615421 0006396 32630 gggccacggaaaccgcgcgcggugaucaaugagccgcguucgcucccguggcccacaa <<<<<<<<<.......<<<<<<<.........>>>>>>>......>>>>>>>>>.... (((((((((.......(((((((.........)))))))......))))))))).... Structure of H/ACA RNP bound to a substrate RNA containing 5BrdU; H/ACA RNA 3lwp E 13 2.5 URS000080DF79_32630 20615421 32630 gagcgngcgguuu ............. ............ Structure of H/ACA RNP bound to a substrate RNA containing 5BrdU; 5'-R(*GP*AP*GP*CP*GP*(BRU)P*GP*CP*GP*GP*UP*UP*U)-3 3lwq D 58 2.678 RF02796 URS000080DEB8_32630 20575532 0006396 32630 gggccacggaaaccgcgcgcggugaucaaugagccgcguucgcucccguggcccacaa <<<<<<<<<.......<<<<<<<.........>>>>>>>......>>>>>>>>>.... (((((((((.......(((((((.........)))))))......))))))))).... Structure of H/ACA RNP bound to a substrate RNA containing 3MU; H/ACA RNA 3lwq E 13 2.678 URS000080DF79_32630 20575532 32630 gagcgngcgguuu ............. ............. Structure of H/ACA RNP bound to a substrate RNA containing 3MU; 5'-R(*GP*AP*GP*CP*GP*(UR3)P*GP*CP*GP*GP*UP*UP*U)-3 3lwr D 58 2.203 RF02796 URS000080DEB8_32630 20575532 0006396 32630 gggccacggaaaccgcgcgcggugaucaaugagccgcguucgcucccguggcccacaa <<<<<<<<<.......<<<<<<<.........>>>>>>>......>>>>>>>>>.... (((((((((.......(((((((.........)))))))......))))))))).... Structure of H/ACA RNP bound to a substrate RNA containing 4SU; H/ACA RNA 3lwr E 12 2.203 URS000080DF79_32630 20575532 32630 gagcggcgguuu ............ ............ Structure of H/ACA RNP bound to a substrate RNA containing 4SU; 5'-R(*GP*AP*GP*CP*GP*(4SU)P*GP*CP*GP*GP*UP*UP*U)-3' 3lwv D 58 2.499 RF02796 URS000080DEB8_32630 20575532 0006396 32630 gggccacggaaaccgcgcgcggugaucaaugagccgcguucgcucccguggcccacaa <<<<<<<<<.......<<<<<<<.........>>>>>>>......>>>>>>>>>.... (((((((((.......(((((((.........)))))))......))))))))).... Structure of H/ACA RNP bound to a substrate RNA containing 2'-deoxyuridine; H/ACA RNA 3lwv E 11 2.499 URS000080DF79_32630 20575532 32630 gagcgcgguuu ........... ........... Structure of H/ACA RNP bound to a substrate RNA containing 2'-deoxyuridine; 5'-R(*GP*AP*GP*CP*GP*(du)P*GP*CP*GP*GP*UP*UP*U)-3' 3mei A 23 1.968 URS000080E209_32630 21245530 32630 ccgccgcgccangccuguggcgg ....................... ....................... Regulatory motif from the thymidylate synthase mRNA; RNA (5'-R(*CP*CP*GP*CP*CP*GP*CP*GP*CP*CP*AP*(5BU)P*GP*CP*CP*UP*GP*UP*GP*GP*CP*GP*G)-3') 3mei B 23 1.968 URS000080E209_32630 21245530 32630 ccgccgcgccangccuguggcgg ....................... ....................... Regulatory motif from the thymidylate synthase mRNA; RNA (5'-R(*CP*CP*GP*CP*CP*GP*CP*GP*CP*CP*AP*(5BU)P*GP*CP*CP*UP*GP*UP*GP*GP*CP*GP*G)-3') 3mij A 12 2.6 URS000080E0FC_9606 21291211 9606 uaggguuagggu ............ ............ Crystal structure of a telomeric RNA G-quadruplex complexed with an acridine-based ligand.; RNA (5'-R(*UP*AP*GP*GP*GP*UP*UP*AP*GP*GP*GP*U)-3') 3mj3 B 29 3.1 URS000080DDC2_32630 20410239 32630 gguuauucagauuagguagucgaaugacc <<<<<<<<.<<<......>>>>>>>>>>> (((.((((.((........)))))).))) Cricket Paralysis Virus IGR IRES Domain 3 RNA bound to selenate; Domain 3 of the cricket paralysis virus intergenic region IRES RNA 3mj3 C 14 3.1 URS000080E14D_32630 20410239 32630 uaagaaauuuaccu .............. .............. Cricket Paralysis Virus IGR IRES Domain 3 RNA bound to selenate; RNA (5'-R(P*UP*AP*AP*GP*AP*AP*AP*UP*UP*UP*AP*CP*CP*U)-3') 3mja B 29 2.8 URS000080DDC2_32630 20410239 32630 gguuauucagauuagguagucgaaugacc <<<<<<<<.<<<......>>>>>>>>>>> (((.((((.((........)))))).))) Cricket Paralysis Virus IGR IRES Domain 3 RNA bound to selenate, structure #2; Domain 3 of the cricket paralysis virus intergenic region IRES RNA 3mja C 14 2.8 URS000080E14D_32630 20410239 32630 uaagaaauuuaccu .............. .............. Cricket Paralysis Virus IGR IRES Domain 3 RNA bound to selenate, structure #2; RNA (5'-R(P*UP*AP*AP*GP*AP*AP*AP*UP*UP*UP*AP*CP*CP*U)-3') 3mjb A 29 2.8 URS000080DDC2_32630 20410239 32630 gguuauucagauuagguagucgaaugacc <<<<<<<<.<<<......>>>>>>>>>>> (((.((((.((........)))))).))) Cricket Paralysis Virus IGR IRES Domain 3 RNA bound to sulfate; Domain 3 of the cricket paralysis virus intergenic region IRES RNA 3mjb B 14 2.8 URS000080E14D_32630 20410239 32630 uaagaaauuuaccu .............. .............. Cricket Paralysis Virus IGR IRES Domain 3 RNA bound to sulfate; RNA (5'-R(P*UP*AP*AP*GP*AP*AP*AP*UP*UP*UP*AP*CP*CP*U)-3') 3mqk D 13 2.8 URS000080E2B6_32630 21149572 32630 guucgauccacag ............. ............. Cbf5-Nop10-Gar1 complex binding with 17mer RNA containing ACA trinucleotide; RNA (5'-R(P*GP*UP*UP*CP*GP*AP*UP*CP*CP*AP*CP*AP*G)-3') 3ncu C 12 2.55 URS000080E329_32630 20581823 32630 nacgcuagcguc ............ ............ Structural and functional insights into pattern recognition by the innate immune receptor RIG-I; 5'-R(*(GDP)P*AP*CP*GP*CP*UP*AP*GP*CP*GP*UP*C)-3' 3ncu D 12 2.55 URS000080E329_32630 20581823 32630 nacgcuagcguc ............ ............ Structural and functional insights into pattern recognition by the innate immune receptor RIG-I; 5'-R(*(GDP)P*AP*CP*GP*CP*UP*AP*GP*CP*GP*UP*C)-3' 3nd3 A 16 1.37 URS000080DEAD_32630 21878548 32630 agagaagauuuuuuuu ................ ................ Uhelix 16-mer dsRNA; 5'-R(*AP*GP*AP*GP*AP*AP*GP*AP*UP*UP*UP*UP*UP*UP*UP*U)-3' 3nd4 A 16 1.524 URS000080DDE8_32630 21878548 32630 agagaagaucuucucu ................ ................ Watson-Crick 16-mer dsRNA; 5'-R(*AP*GP*AP*GP*AP*AP*GP*AP*UP*CP*UP*UP*CP*UP*CP*U)-3' 3nj6 A 10 0.95 URS000080DE08_32630 20702420 32630 ggcagcagcc .......... .......... 0.95 A resolution X-ray structure of (GGCAGCAGCC)2; 5'-R(*GP*GP*CP*AP*GP*CP*AP*GP*CP*C)-3' 3nj7 A 10 1.904 URS000080DE08_32630 20702420 32630 ggcagcagcc .......... .......... 1.9 A resolution X-ray structure of (GGCAGCAGCC)2; 5'-R(*GP*GP*CP*AP*GP*CP*AP*GP*CP*C)-3' 3nj7 B 10 1.904 URS000080DE08_32630 20702420 32630 ggcagcagcc .......... .......... 1.9 A resolution X-ray structure of (GGCAGCAGCC)2; 5'-R(*GP*GP*CP*AP*GP*CP*AP*GP*CP*C)-3' 3nj7 C 10 1.904 URS000080DE08_32630 20702420 32630 ggcagcagcc .......... .......... 1.9 A resolution X-ray structure of (GGCAGCAGCC)2; 5'-R(*GP*GP*CP*AP*GP*CP*AP*GP*CP*C)-3' 3nj7 D 10 1.904 URS000080DE08_32630 20702420 32630 ggcagcagcc .......... .......... 1.9 A resolution X-ray structure of (GGCAGCAGCC)2; 5'-R(*GP*GP*CP*AP*GP*CP*AP*GP*CP*C)-3' 3nj7 E 10 1.904 URS000080DE08_32630 20702420 32630 ggcagcagcc .......... .......... 1.9 A resolution X-ray structure of (GGCAGCAGCC)2; 5'-R(*GP*GP*CP*AP*GP*CP*AP*GP*CP*C)-3' 3nj7 F 10 1.904 URS000080DE08_32630 20702420 32630 ggcagcagcc .......... .......... 1.9 A resolution X-ray structure of (GGCAGCAGCC)2; 5'-R(*GP*GP*CP*AP*GP*CP*AP*GP*CP*C)-3' 3nkb B 64 1.916 URS000080DDAA_9606 20677830 9606 gguccgcagccuccucgcggcgcaagcugggcaacauuccgaaagguaauggcgaaugcggacc <<<<<<<<<<<.((....>>>.......))....<<<<<<....>>.>>>>.....>>>>>>>> (((((((((((.[[....))).......]]....((((((....)).)))).....)))))))) A 1.9A crystal structure of the HDV ribozyme precleavage suggests both Lewis acid and general acid mechanisms contribute to phosphodiester cleavage; The hepatitis delta virus ribozyme 3nmu D 34 2.729 URS000080E0DB_2261 20864039 2261 gccguugaagcucugaccgaaaggcgugaugagc ............<...<<....>>......>... ............(...((....))......)... Crystal Structure of substrate-bound halfmer box C/D RNP; RNA (34-MER) 3nmu E 34 2.729 URS000080E0DB_2261 20864039 2261 gccguugaagcucugaccgaaaggcgugaugagc ................<<....>>.......... ............(...((....))......)... Crystal Structure of substrate-bound halfmer box C/D RNP; RNA (34-MER) 3nmu I 13 2.729 URS000080E0A7_32630 20864039 32630 gagcuucaacggc ............. ............. Crystal Structure of substrate-bound halfmer box C/D RNP; RNA (5'-R(*GP*AP*GP*CP*UP*UP*CP*AP*AP*CP*GP*GP*C)-3') 3nmu K 12 2.729 URS000080E0A7_32630 20864039 32630 agcuucaacggc ............ ............ Crystal Structure of substrate-bound halfmer box C/D RNP; RNA (5'-R(*GP*AP*GP*CP*UP*UP*CP*AP*AP*CP*GP*GP*C)-3') 3nvk K 24 3.209 URS000080E0DB_32630 20864039 32630 agcucugaccgaaaggcgugauga ....<...<<....>>......>. ....(...(......)......). Structural basis for substrate placement by an archaeal box C/D ribonucleoprotein particle; RNA (5'-R(*GP*CP*CP*GP*UP*UP*GP*AP*AP*GP*CP*UP*CP*UP*GP*AP*CP*CP*GP*AP*AP*AP*GP*GP*CP*GP*UP*GP*AP*UP*GP*AP*GP*C)-3') 3nvk L 24 3.209 URS000080E0DB_32630 20864039 32630 agcucugaccgaaaggcgugauga ........<<....>>........ ....(...(......)......). Structural basis for substrate placement by an archaeal box C/D ribonucleoprotein particle; RNA (5'-R(*GP*CP*CP*GP*UP*UP*GP*AP*AP*GP*CP*UP*CP*UP*GP*AP*CP*CP*GP*AP*AP*AP*GP*GP*CP*GP*UP*GP*AP*UP*GP*AP*GP*C)-3') 3o3i A 14 2.801 URS000080E0AC_32630 21193640 32630 gcgaauauucgcuu .............. .............. Crystal Structure of human Hiwi1 PAZ domain (residues 277-399) in complex with 14-mer RNA (12-bp + 2-nt overhang) containing 2'-OH at its 3'-end; RNA (5'-R(*GP*CP*GP*AP*AP*UP*AP*UP*UP*CP*GP*CP*UP*U)-3') 3o6e A 14 2.904 URS000080E0AC_32630 21193640 32630 gcgaauauucgcun .............. .............. Crystal Structure of human Hiwi1 PAZ domain (residues 277-399) in complex with 14-mer RNA (12-bp + 2-nt overhang) containing 2'-OCH3 at its 3'-end; RNA (5'-R(*GP*CP*GP*AP*AP*UP*AP*UP*UP*CP*GP*CP*UP*(OMU))-3') 3o7v A 14 2.1 URS000080E0AC_32630 21193640 32630 gcgaauauucgcun .............. .............. Crystal Structure of human Hiwi1 (V361M) PAZ domain (residues 277-399) in complex with 14-mer RNA (12-bp + 2-nt overhang) containing 2'-OCH3 at its 3'-end; RNA (5'-R(*GP*CP*GP*AP*AP*UP*AP*UP*UP*CP*GP*CP*UP*(OMU))-3') 3og8 C 14 2.4 URS000080DFA5_32630 20961956 32630 ggcgcgcgcgcgcc .............. .............. Crystal structure of human RIG-I CTD bound to a 14-bp blunt-ended dsRNA; RNA (5'-R(*GP*GP*CP*GP*CP*GP*CP*GP*CP*GP*CP*GP*CP*C)-3') 3og8 D 14 2.4 URS000080DFA5_32630 20961956 32630 ggcgcgcgcgcgcc .............. .............. Crystal structure of human RIG-I CTD bound to a 14-bp blunt-ended dsRNA; RNA (5'-R(*GP*GP*CP*GP*CP*GP*CP*GP*CP*GP*CP*GP*CP*C)-3') 3ok2 B 10 1.963 URS000080E1AA_32630 22638588 32630 ggcauuacgg .......... .......... Crystal structure of the ANA:RNA decamer without lattice translocation defects; GGCAUUACGG 3ok2 D 10 1.963 URS000080E1AA_32630 22638588 32630 ggcauuacgg .......... .......... Crystal structure of the ANA:RNA decamer without lattice translocation defects; GGCAUUACGG 3ok2 F 10 1.963 URS000080E1AA_32630 22638588 32630 ggcauuacgg .......... .......... Crystal structure of the ANA:RNA decamer without lattice translocation defects; GGCAUUACGG 3ok4 B 10 1.149 URS000080E1AA_32630 32630 ggcauuacgg .......... .......... Crystal structure of the ANA:RNA decamer suffering from lattice translocation defects; RNA 3ok4 D 10 1.149 URS000080E1AA_32630 32630 ggcauuacgg .......... .......... Crystal structure of the ANA:RNA decamer suffering from lattice translocation defects; RNA 3ok4 F 10 1.149 URS000080E1AA_32630 32630 ggcauuacgg .......... .......... Crystal structure of the ANA:RNA decamer suffering from lattice translocation defects; RNA 3ok4 H 10 1.149 URS000080E1AA_32630 32630 ggcauuacgg .......... .......... Crystal structure of the ANA:RNA decamer suffering from lattice translocation defects; RNA 3ok4 J 10 1.149 URS000080E1AA_32630 32630 ggcauuacgg .......... .......... Crystal structure of the ANA:RNA decamer suffering from lattice translocation defects; RNA 3ok4 L 10 1.149 URS000080E1AA_32630 32630 ggcauuacgg .......... .......... Crystal structure of the ANA:RNA decamer suffering from lattice translocation defects; RNA 3ok4 N 10 1.149 URS000080E1AA_32630 32630 ggcauuacgg .......... .......... Crystal structure of the ANA:RNA decamer suffering from lattice translocation defects; RNA 3ok4 P 10 1.149 URS000080E1AA_32630 32630 ggcauuacgg .......... .......... Crystal structure of the ANA:RNA decamer suffering from lattice translocation defects; RNA 3ok4 R 10 1.149 URS000080E1AA_32630 32630 ggcauuacgg .......... .......... Crystal structure of the ANA:RNA decamer suffering from lattice translocation defects; RNA 3ok4 T 10 1.149 URS000080E1AA_32630 32630 ggcauuacgg .......... .......... Crystal structure of the ANA:RNA decamer suffering from lattice translocation defects; RNA 3ok4 V 10 1.149 URS000080E1AA_32630 32630 ggcauuacgg .......... .......... Crystal structure of the ANA:RNA decamer suffering from lattice translocation defects; RNA 3ok4 X 10 1.149 URS000080E1AA_32630 32630 ggcauuacgg .......... .......... Crystal structure of the ANA:RNA decamer suffering from lattice translocation defects; RNA 3ok4 Z 10 1.149 URS000080E1AA_32630 32630 ggcauuacgg .......... .......... Crystal structure of the ANA:RNA decamer suffering from lattice translocation defects; RNA 3ok4 2 10 1.149 URS000080E1AA_32630 32630 ggcauuacgg .......... .......... Crystal structure of the ANA:RNA decamer suffering from lattice translocation defects; RNA 3ok4 4 10 1.149 URS000080E1AA_32630 32630 ggcauuacgg .......... .......... Crystal structure of the ANA:RNA decamer suffering from lattice translocation defects; RNA 3ol6 B 18 2.5 URS000080E368_32630 21148772 32630 ccaggucucucguccgga .................. .................. Poliovirus polymerase elongation complex; RNA (5'-R(*AP*AP*GP*UP*CP*UP*CP*CP*AP*GP*GP*UP*CP*UP*CP*UP*CP*GP*UP*CP*CP*GP*GP*AP*AP*A)-3') 3ol6 C 14 2.5 URS000080E1D2_32630 21148772 32630 gcccggacgagaga .............. .............. Poliovirus polymerase elongation complex; RNA (5'-R(*GP*CP*CP*CP*GP*GP*AP*CP*GP*AP*GP*AP*GP*A)-3') 3ol6 F 18 2.5 URS000080E368_32630 21148772 32630 ccaggucucucguccgga .................. .................. Poliovirus polymerase elongation complex; RNA (5'-R(*AP*AP*GP*UP*CP*UP*CP*CP*AP*GP*GP*UP*CP*UP*CP*UP*CP*GP*UP*CP*CP*GP*GP*AP*AP*A)-3') 3ol6 G 14 2.5 URS000080E1D2_32630 21148772 32630 gcccggacgagaga .............. .............. Poliovirus polymerase elongation complex; RNA (5'-R(*GP*CP*CP*CP*GP*GP*AP*CP*GP*AP*GP*AP*GP*A)-3') 3ol6 J 19 2.5 URS000080E368_32630 21148772 32630 uccaggucucucguccgga ................... ................... Poliovirus polymerase elongation complex; RNA (5'-R(*AP*AP*GP*UP*CP*UP*CP*CP*AP*GP*GP*UP*CP*UP*CP*UP*CP*GP*UP*CP*CP*GP*GP*AP*AP*A)-3') 3ol6 K 14 2.5 URS000080E1D2_32630 21148772 32630 gcccggacgagaga .............. .............. Poliovirus polymerase elongation complex; RNA (5'-R(*GP*CP*CP*CP*GP*GP*AP*CP*GP*AP*GP*AP*GP*A)-3') 3ol6 N 19 2.5 URS000080E368_32630 21148772 32630 uccaggucucucguccgga ................... ................... Poliovirus polymerase elongation complex; RNA (5'-R(*AP*AP*GP*UP*CP*UP*CP*CP*AP*GP*GP*UP*CP*UP*CP*UP*CP*GP*UP*CP*CP*GP*GP*AP*AP*A)-3') 3ol6 O 14 2.5 URS000080E1D2_32630 21148772 32630 gcccggacgagaga .............. .............. Poliovirus polymerase elongation complex; RNA (5'-R(*GP*CP*CP*CP*GP*GP*AP*CP*GP*AP*GP*AP*GP*A)-3') 3ol7 B 18 2.7 URS000080E368_32630 21148772 32630 ccaggucucucguccgga .................. .................. Poliovirus polymerase elongation complex with CTP; RNA (5'-R(*AP*AP*GP*UP*CP*UP*CP*CP*AP*GP*GP*UP*CP*UP*CP*UP*CP*GP*UP*CP*CP*GP*GP*AP*AP*A)-3') 3ol7 C 15 2.7 URS000080E1BB_32630 21148772 32630 gcccggacgagagac ............... ............... Poliovirus polymerase elongation complex with CTP; RNA (5'-R(*GP*CP*CP*CP*GP*GP*AP*CP*GP*AP*GP*AP*GP*AP*C)-3') 3ol7 F 18 2.7 URS000080E368_32630 21148772 32630 ccaggucucucguccgga .................. .................. Poliovirus polymerase elongation complex with CTP; RNA (5'-R(*AP*AP*GP*UP*CP*UP*CP*CP*AP*GP*GP*UP*CP*UP*CP*UP*CP*GP*UP*CP*CP*GP*GP*AP*AP*A)-3') 3ol7 G 15 2.7 URS000080E1BB_32630 21148772 32630 gcccggacgagagac ............... ............... Poliovirus polymerase elongation complex with CTP; RNA (5'-R(*GP*CP*CP*CP*GP*GP*AP*CP*GP*AP*GP*AP*GP*AP*C)-3') 3ol7 J 16 2.7 URS000080E368_32630 21148772 32630 caggucucucguccgg ................ ................ Poliovirus polymerase elongation complex with CTP; RNA (5'-R(*AP*AP*GP*UP*CP*UP*CP*CP*AP*GP*GP*UP*CP*UP*CP*UP*CP*GP*UP*CP*CP*GP*GP*AP*AP*A)-3') 3ol7 K 15 2.7 URS000080E1BB_32630 21148772 32630 gcccggacgagagac ............... ............... Poliovirus polymerase elongation complex with CTP; RNA (5'-R(*GP*CP*CP*CP*GP*GP*AP*CP*GP*AP*GP*AP*GP*AP*C)-3') 3ol7 N 16 2.7 URS000080E368_32630 21148772 32630 caggucucucguccgg ................ ................ Poliovirus polymerase elongation complex with CTP; RNA (5'-R(*AP*AP*GP*UP*CP*UP*CP*CP*AP*GP*GP*UP*CP*UP*CP*UP*CP*GP*UP*CP*CP*GP*GP*AP*AP*A)-3') 3ol7 O 15 2.7 URS000080E1BB_32630 21148772 32630 gcccggacgagagac ............... ............... Poliovirus polymerase elongation complex with CTP; RNA (5'-R(*GP*CP*CP*CP*GP*GP*AP*CP*GP*AP*GP*AP*GP*AP*C)-3') 3ol8 B 17 2.75 URS000080E368_32630 21148772 32630 caggucucucguccgga ................. ................. Poliovirus polymerase elongation complex with CTP-Mn; RNA (5'-R(*AP*AP*GP*UP*CP*UP*CP*CP*AP*GP*GP*UP*CP*UP*CP*UP*CP*GP*UP*CP*CP*GP*GP*AP*AP*A)-3') 3ol8 C 15 2.75 URS000080E1BB_32630 21148772 32630 gcccggacgagagac ............... ............... Poliovirus polymerase elongation complex with CTP-Mn; RNA (5'-R(*GP*CP*CP*CP*GP*GP*AP*CP*GP*AP*GP*AP*GP*AP*C)-3') 3ol8 F 17 2.75 URS000080E368_32630 21148772 32630 caggucucucguccgga ................. ................. Poliovirus polymerase elongation complex with CTP-Mn; RNA (5'-R(*AP*AP*GP*UP*CP*UP*CP*CP*AP*GP*GP*UP*CP*UP*CP*UP*CP*GP*UP*CP*CP*GP*GP*AP*AP*A)-3') 3ol8 G 15 2.75 URS000080E1BB_32630 21148772 32630 gcccggacgagagac ............... ............... Poliovirus polymerase elongation complex with CTP-Mn; RNA (5'-R(*GP*CP*CP*CP*GP*GP*AP*CP*GP*AP*GP*AP*GP*AP*C)-3') 3ol8 J 17 2.75 URS000080E368_32630 21148772 32630 caggucucucguccgga ................. ................. Poliovirus polymerase elongation complex with CTP-Mn; RNA (5'-R(*AP*AP*GP*UP*CP*UP*CP*CP*AP*GP*GP*UP*CP*UP*CP*UP*CP*GP*UP*CP*CP*GP*GP*AP*AP*A)-3') 3ol8 K 15 2.75 URS000080E1BB_32630 21148772 32630 gcccggacgagagac ............... ............... Poliovirus polymerase elongation complex with CTP-Mn; RNA (5'-R(*GP*CP*CP*CP*GP*GP*AP*CP*GP*AP*GP*AP*GP*AP*C)-3') 3ol8 N 17 2.75 URS000080E368_32630 21148772 32630 caggucucucguccgga ................. ................. Poliovirus polymerase elongation complex with CTP-Mn; RNA (5'-R(*AP*AP*GP*UP*CP*UP*CP*CP*AP*GP*GP*UP*CP*UP*CP*UP*CP*GP*UP*CP*CP*GP*GP*AP*AP*A)-3') 3ol8 O 15 2.75 URS000080E1BB_32630 21148772 32630 gcccggacgagagac ............... ............... Poliovirus polymerase elongation complex with CTP-Mn; RNA (5'-R(*GP*CP*CP*CP*GP*GP*AP*CP*GP*AP*GP*AP*GP*AP*C)-3') 3ol9 B 18 2.25 URS000080E368_32630 21148772 32630 ccaggucucucguccgga .................. .................. Poliovirus polymerase elongation complex with 3'-deoxy-CTP; RNA (5'-R(*AP*AP*GP*UP*CP*UP*CP*CP*AP*GP*GP*UP*CP*UP*CP*UP*CP*GP*UP*CP*CP*GP*GP*AP*AP*A)-3') 3ol9 C 15 2.25 URS000080E0FE_32630 21148772 32630 gcccggacgagagan ............... ............... Poliovirus polymerase elongation complex with 3'-deoxy-CTP; RNA (5'-R(*GP*CP*CP*CP*GP*GP*AP*CP*GP*AP*GP*AP*GP*AP*(O2C))-3') 3ol9 F 18 2.25 URS000080E368_32630 21148772 32630 ccaggucucucguccgga .................. .................. Poliovirus polymerase elongation complex with 3'-deoxy-CTP; RNA (5'-R(*AP*AP*GP*UP*CP*UP*CP*CP*AP*GP*GP*UP*CP*UP*CP*UP*CP*GP*UP*CP*CP*GP*GP*AP*AP*A)-3') 3ol9 G 15 2.25 URS000080E0FE_32630 21148772 32630 gcccggacgagagan ............... ............... Poliovirus polymerase elongation complex with 3'-deoxy-CTP; RNA (5'-R(*GP*CP*CP*CP*GP*GP*AP*CP*GP*AP*GP*AP*GP*AP*(O2C))-3') 3ol9 J 19 2.25 URS000080E368_32630 21148772 32630 uccaggucucucguccgga ................... ................... Poliovirus polymerase elongation complex with 3'-deoxy-CTP; RNA (5'-R(*AP*AP*GP*UP*CP*UP*CP*CP*AP*GP*GP*UP*CP*UP*CP*UP*CP*GP*UP*CP*CP*GP*GP*AP*AP*A)-3') 3ol9 K 15 2.25 URS000080E0FE_32630 21148772 32630 gcccggacgagagan ............... ............... Poliovirus polymerase elongation complex with 3'-deoxy-CTP; RNA (5'-R(*GP*CP*CP*CP*GP*GP*AP*CP*GP*AP*GP*AP*GP*AP*(O2C))-3') 3ol9 N 19 2.25 URS000080E368_32630 21148772 32630 uccaggucucucguccgga ................... ................... Poliovirus polymerase elongation complex with 3'-deoxy-CTP; RNA (5'-R(*AP*AP*GP*UP*CP*UP*CP*CP*AP*GP*GP*UP*CP*UP*CP*UP*CP*GP*UP*CP*CP*GP*GP*AP*AP*A)-3') 3ol9 O 15 2.25 URS000080E0FE_32630 21148772 32630 gcccggacgagagan ............... ............... Poliovirus polymerase elongation complex with 3'-deoxy-CTP; RNA (5'-R(*GP*CP*CP*CP*GP*GP*AP*CP*GP*AP*GP*AP*GP*AP*(O2C))-3') 3ola B 17 2.55 URS000080E368_32630 21148772 32630 ccaggucucucguccgg ................. ................. Poliovirus polymerase elongation complex with 2'-deoxy-CTP; RNA (5'-R(*AP*AP*GP*UP*CP*UP*CP*CP*AP*GP*GP*UP*CP*UP*CP*UP*CP*GP*UP*CP*CP*GP*GP*AP*AP*A)-3') 3ola C 15 2.55 URS000080E1BB_32630 21148772 32630 gcccggacgagagac ............... ............... Poliovirus polymerase elongation complex with 2'-deoxy-CTP; DNA/RNA (5'-R(*GP*CP*CP*CP*GP*GP*AP*CP*GP*AP*GP*AP*GP*A)-D(P*C)-3') 3ola F 17 2.55 URS000080E368_32630 21148772 32630 ccaggucucucguccgg ................. ................. Poliovirus polymerase elongation complex with 2'-deoxy-CTP; RNA (5'-R(*AP*AP*GP*UP*CP*UP*CP*CP*AP*GP*GP*UP*CP*UP*CP*UP*CP*GP*UP*CP*CP*GP*GP*AP*AP*A)-3') 3ola G 15 2.55 URS000080E1BB_32630 21148772 32630 gcccggacgagagac ............... ............... Poliovirus polymerase elongation complex with 2'-deoxy-CTP; DNA/RNA (5'-R(*GP*CP*CP*CP*GP*GP*AP*CP*GP*AP*GP*AP*GP*A)-D(P*C)-3') 3ola J 18 2.55 URS000080E368_32630 21148772 32630 uccaggucucucguccgg .................. .................. Poliovirus polymerase elongation complex with 2'-deoxy-CTP; RNA (5'-R(*AP*AP*GP*UP*CP*UP*CP*CP*AP*GP*GP*UP*CP*UP*CP*UP*CP*GP*UP*CP*CP*GP*GP*AP*AP*A)-3') 3ola K 14 2.55 URS000080E1D2_32630 21148772 32630 gcccggacgagaga .............. .............. Poliovirus polymerase elongation complex with 2'-deoxy-CTP; RNA (5'-R(*GP*CP*CP*CP*GP*GP*AP*CP*GP*AP*GP*AP*GP*A)-3') 3ola N 18 2.55 URS000080E368_32630 21148772 32630 uccaggucucucguccgg .................. .................. Poliovirus polymerase elongation complex with 2'-deoxy-CTP; RNA (5'-R(*AP*AP*GP*UP*CP*UP*CP*CP*AP*GP*GP*UP*CP*UP*CP*UP*CP*GP*UP*CP*CP*GP*GP*AP*AP*A)-3') 3ola O 14 2.55 URS000080E1D2_32630 21148772 32630 gcccggacgagaga .............. .............. Poliovirus polymerase elongation complex with 2'-deoxy-CTP; RNA (5'-R(*GP*CP*CP*CP*GP*GP*AP*CP*GP*AP*GP*AP*GP*A)-3') 3olb B 18 2.41 URS000080E368_32630 21148772 32630 ccaggucucucguccgga .................. .................. Poliovirus polymerase elongation complex with 2',3'-dideoxy-ctp; RNA (5'-R(*AP*AP*GP*UP*CP*U*CP*CP*AP*GP*GP*UP*CP*UP*CP*UP*CP*GP*UP*CP*CP*GP*GP*AP*AP*A)-3') 3olb C 14 2.41 URS000080E1D2_32630 21148772 32630 gcccggacgagaga .............. .............. Poliovirus polymerase elongation complex with 2',3'-dideoxy-ctp; RNA (5'-R(*GP*CP*CP*CP*GP*GP*AP*CP*GP*AP*GP*AP*GP*A)-3') 3olb F 18 2.41 URS000080E368_32630 21148772 32630 ccaggucucucguccgga .................. .................. Poliovirus polymerase elongation complex with 2',3'-dideoxy-ctp; RNA (5'-R(*AP*AP*GP*UP*CP*U*CP*CP*AP*GP*GP*UP*CP*UP*CP*UP*CP*GP*UP*CP*CP*GP*GP*AP*AP*A)-3') 3olb G 14 2.41 URS000080E1D2_32630 21148772 32630 gcccggacgagaga .............. .............. Poliovirus polymerase elongation complex with 2',3'-dideoxy-ctp; RNA (5'-R(*GP*CP*CP*CP*GP*GP*AP*CP*GP*AP*GP*AP*GP*A)-3') 3olb J 19 2.41 URS000080E368_32630 21148772 32630 uccaggucucucguccgga ................... ................... Poliovirus polymerase elongation complex with 2',3'-dideoxy-ctp; RNA (5'-R(*AP*AP*GP*UP*CP*U*CP*CP*AP*GP*GP*UP*CP*UP*CP*UP*CP*GP*UP*CP*CP*GP*GP*AP*AP*A)-3') 3olb K 14 2.41 URS000080E1D2_32630 21148772 32630 gcccggacgagaga .............. .............. Poliovirus polymerase elongation complex with 2',3'-dideoxy-ctp; RNA (5'-R(*GP*CP*CP*CP*GP*GP*AP*CP*GP*AP*GP*AP*GP*A)-3') 3olb N 19 2.41 URS000080E368_32630 21148772 32630 uccaggucucucguccgga ................... ................... Poliovirus polymerase elongation complex with 2',3'-dideoxy-ctp; RNA (5'-R(*AP*AP*GP*UP*CP*U*CP*CP*AP*GP*GP*UP*CP*UP*CP*UP*CP*GP*UP*CP*CP*GP*GP*AP*AP*A)-3') 3olb O 14 2.41 URS000080E1D2_32630 21148772 32630 gcccggacgagaga .............. .............. Poliovirus polymerase elongation complex with 2',3'-dideoxy-ctp; RNA (5'-R(*GP*CP*CP*CP*GP*GP*AP*CP*GP*AP*GP*AP*GP*A)-3') 3ow2 0 2754 2.7 RF02540,RF00002 URS000080DF99_2238 0003735 0005840 2238 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagccauggggagccgcacggaggcgaagaaccauggauuuccgaaugagaaucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaaugugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucucgacgaagucucuuggaacagagcgugauacagggugacaaccccguacucgagaccaguacgacgugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccucgacgaaugaccgacgcgcgagcguccaguaagacucacgggaagccgauguucugucguacguuuugaaaaacgagccagggagugugucugcauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguccugucaaacuccaaacuuacagacgccguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaaguaggggugaaaacuccuauggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucauaccgcaacucgacuaugacgaaaugggaaacggguuaauauucccgugccacuaugcagugaaaguugacgcccuggggucgaucacgcugggcaucgcccagucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcauaguguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcgggggucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcaaagacccuauggagcuuuacugcaggcugucgcugaggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggcuaucucagccggggacccggcgaagagugcaagagcaaaagauagcuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugagguuguucgccuauuaaaggaggucgugagcuggguuuagaccgucgugagacaggucggcugcuaucuacuggguguguaggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa 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...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(.)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......(..(.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......)..)...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......(...(((.....))).............)).....)))))))))......(.((((((((((....((((((..((....(....(((((....))))).....)...))..))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.(((....(((((((....)))))))....[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..(...)..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((..{{.))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((...))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((..)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((..))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))....((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Crystal Structure of Enhanced Macrolide Bound to 50S Ribosomal Subunit; 23S RIBOSOMAL RNA 3ow2 9 122 2.7 RF00001 URS00003592C7_2238 0003735 0005840 2238 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccggggaguacuggagugcgcgagccucugggaaacccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<<<<.....<<<<<<.<<....>>>>>>>>....>>>>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...(((((.....((((((.((....))))))))....)))))...))))))... Crystal Structure of Enhanced Macrolide Bound to 50S Ribosomal Subunit; 5S RIBOSOMAL RNA 3p22 A 40 2.501 URS000080DEE3_32630 21109672 32630 ngcuggguuuuuccuucgaaagaagguuuuuaucccaguc <<<<<<<.....<<<<<....>>>>>.......>>>>>>> (((((((.....(((((....))))).......))))))) Crystal structure of the ENE, a viral RNA stability element, in complex with A9 RNA; Core ENE hairpin from KSHV PAN RNA 3p22 C 40 2.501 URS000080DEE3_32630 21109672 32630 ngcuggguuuuuccuucgaaagaagguuuuuaucccaguc <<<<<<<.....<<<<<....>>>>>.......>>>>>>> (((((((.....(((((....))))).......))))))) Crystal structure of the ENE, a viral RNA stability element, in complex with A9 RNA; Core ENE hairpin from KSHV PAN RNA 3p22 E 40 2.501 URS000080DEE3_32630 21109672 32630 ngcuggguuuuuccuucgaaagaagguuuuuaucccaguc <<<<<<<.....<<<<<....>>>>>.......>>>>>>> (((((((.....(((((....))))).......))))))) Crystal structure of the ENE, a viral RNA stability element, in complex with A9 RNA; Core ENE hairpin from KSHV PAN RNA 3p22 G 40 2.501 URS000080DEE3_32630 21109672 32630 ngcuggguuuuuccuucgaaagaagguuuuuaucccaguc <<<<<<<.....<<<<<....>>>>>.......>>>>>>> (((((((.....(((((....))))).......))))))) Crystal structure of the ENE, a viral RNA stability element, in complex with A9 RNA; Core ENE hairpin from KSHV PAN RNA 3p59 A 15 2.1793 URS000080DE90_32630 21464284 32630 ccggaggaacuacng ............... ............... First Crystal Structure of a RNA Nanosquare; RNA (5'-R(*CP*CP*GP*GP*AP*GP*GP*AP*AP*CP*UP*AP*CP*(5BU)P*G)-3') 3p59 B 10 2.1793 URS000080DF2E_32630 21464284 32630 ccggcagccu .......... .......... First Crystal Structure of a RNA Nanosquare; RNA (5'-R(*CP*CP*GP*GP*CP*AP*GP*CP*CP*U)-3') 3p59 C 15 2.1793 URS000080DE90_32630 21464284 32630 ccggaggaacuacng ............... ............... First Crystal Structure of a RNA Nanosquare; RNA (5'-R(*CP*CP*GP*GP*AP*GP*GP*AP*AP*CP*UP*AP*CP*(5BU)P*G)-3') 3p59 D 10 2.1793 URS000080DF2E_32630 21464284 32630 ccggcagccu .......... .......... First Crystal Structure of a RNA Nanosquare; RNA (5'-R(*CP*CP*GP*GP*CP*AP*GP*CP*CP*U)-3') 3p59 E 15 2.1793 URS000080DE90_32630 21464284 32630 ccggaggaacuacng ............... ............... First Crystal Structure of a RNA Nanosquare; RNA (5'-R(*CP*CP*GP*GP*AP*GP*GP*AP*AP*CP*UP*AP*CP*(5BU)P*G)-3') 3p59 F 10 2.1793 URS000080DF2E_32630 21464284 32630 ccggcagccu .......... .......... First Crystal Structure of a RNA Nanosquare; RNA (5'-R(*CP*CP*GP*GP*CP*AP*GP*CP*CP*U)-3') 3p59 G 13 2.1793 URS000080DE90_32630 21464284 32630 ccggaggaaccng ............. ............. First Crystal Structure of a RNA Nanosquare; RNA (5'-R(*CP*CP*GP*GP*AP*GP*GP*AP*AP*CP*UP*AP*CP*(5BU)P*G)-3') 3p59 H 10 2.1793 URS000080DF2E_32630 21464284 32630 ccggcagccu .......... .......... First Crystal Structure of a RNA Nanosquare; RNA (5'-R(*CP*CP*GP*GP*CP*AP*GP*CP*CP*U)-3') 3pio X 2657 3.2473 RF02540,RF02541 URS000080DEF1_243230 21282615 0003735 0005840 243230 ggucaagauaguaaggguccacgguggaugcccuggcgcuggagccgaugaaggacgcgauuaccugcgaaaagccccgacgagcuggagauacgcuuugacucggggauguccgaauggggaaacccaccucguaagagguauccgcaaggaugggaacucagggaacugaaacaucucaguaccugaaggagaagaaagagaauucgauuccguuaguagcggcgagcgaacccggaucagcccaaucaagccgaaguggcuggaaagcuacaccucagaaggugagaguccuguaggcgaacgagaggucguuguucgugaaacgaugacugaauccgcgcggaccaccgcgcaaggcuaaauacucccagugaccgauagcgcauaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaagagaaccugaaaccguggacuuacaagcagucauggcaccuuaugcguguuauggcgugccuauugaagcaugagccggcgacuuagaccugacgugcgagcuuaaguugaaaaacggaggcggagcgaaagcgaguccgaauagggcggcauuaguacgucgggcuagacucgaaaccaggugagcuaagcaugaccagguugaaacccccggggggcggaggaccgaaccggugccugcugaaacagucucggaugaguuguguuuaggagugaaaagcuaaccgaaccuggagauagcuaguucuccccgaaauguauugagguacagccucggauguugaccauguccuguagagcacucacaaggcuaaaccuuaugaaacuccgaaggggcacgcguuuaguccgggagugaggcugcgagagcuaacuuccguagccgagagggaaacaacccagaccaucagcuaaggucccuaaaugaucgcucagugguuaaggaugugucgucgcauagacagccaggagguuggcuuagaagcagccacccuucaaagagugcguaauagcucacuggucgagugacgaugcgccgaaaaugaucggggcucaagugaucuaccgaagcuauggauucaacucggaguugucugguaggggagcguucaguccgcggagaagccauaccggaaggagugguggagccgacugaagugcggaugccggcaugaguaacgauaaaagaagugagaaucuucuucgccguaaggacaaggguuccuggggaagggucguccgcccagggaaagucgggaccuaaggugaggccgaacggcgcagccgauggacagcaggucaagauuccugcaccgaucauguggagugauggagggacgcauuacgcuauccaaugccaagcuauggcuaugcugguugguacgcucaagggcgaucgggucagaaaaucuaccggucugccucagacguaucgggagcuuccucggaagcgaaguuggaaacgcgacggugccaagaaaagcuucuaaacguugaaacaugauugcccguaccgcaaaccgacacagguguccgagugucaaugcacuaaggcgcgcgagagaacccucguuaaggaacuuugcaaucucaccccguaacuucggaagaagggguccccacgcuucgcguggggcgcagugaauaggcccaggcgacuguuuaccaaaaucacagcacucugccaacacgaacaguggacguauagggugugacgccugcccggugccggaaggucaaguggagcggugcaagcugcgaaaugaagccccggugaacggcuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaggcguaacgaucugggcgcugucucaacgagggacucggugaaauugaauuggcuguaaagaugcggccuacccguagcaggacgaaaagaccccguggagcuuuacuauagucuggcauugggauucggguuacuuggauuucuaaccugaaaaaucacuuucggggaccgugcuuggcggguaguuugacuggggcggucgccucccaaaauguaacggaggcgcccaaaggucaccucaagacgguuggaaaucgucuguagagcgcaaagguagaagguggcuugacugcgagacugacacgucgagcagggaggaaacucgggcuuagugaaccggugguaccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagaguccauaucggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgcuacgggcgcaggagaauugaggggaguugcuccuaguacgagaggaccggagugaacggaccgcuggucucccugcugucguaccaacggcacaugcaggguagcuauguccggaacggauaaccgcugaaagcaucuaagcgggaagccagccccaagaugaguucucccacugagguaagacucccggaagaccaccggguuaagaggccaggcgugcacgcauagcaauguguucagcggacuggugcucaucagucgaggucuugacc .<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<...<<.))..))..>>......>>>>>>...>>>....<<<....>>><<<<<....>>>>><<<<....>>>>>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<......<<.....>>.....>>>>...<<<...<<..<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>....>>..<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>..............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<.......>>>>>>>>>>...<............>.<<<<<<....<<<.<<<<<<<<<<..<<<...<<<....>>>...>>>...<<....>>...<........>.........>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<.....<<<<<.>>>>>......>>>...<<<..<.<<........>>.>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<...<<<<.<<<<<<...<<<...<<<.<<<<.....>>>>.>>>..>>.>...>>>>>>.>.>>>..>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><..<<<<.....>>>>..>....>>>>>><.<<<<<<<.<<......<<<<<.<<....>>.>>>>>...>>.>>>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<<..>>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<...<<...<<<<....<<<<..<<<..<<<<<.<<<<.<<...[[....>>>>>><<<<<<<.<<..<<<.<<<<<<...<<.....>>.>>>>>>..>>>..>>>>>>>>>...<<<<<....>>>>>....>>>>>...>>>...>>>>.........>>>>...>>......>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<<<...>>>>>>>>............<<<<<<<<<..<<...........>>..<<<<<<<.....<<<.....>>>.......>>>>>>>.<<<<<..<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.>>>>>>>>>>>...<<<<<<........>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<....<<<...<<<<<<<<<<<.]].>>>>>>...>>>>>...>>>..>>>>>....<<....<<<<<...........>>>>>....>>..>>>>.......>>>>>>>..<<.>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>>. (..(((((......((((((((((.....(((..(...((((.(((......((((((.[......)))......(((((...((......]..))......)))))....)))....(((....)))(((((....)))))(.((....)).)))...((((((.....(...[..)......))))).).........((....))...((((......((.]...)).....))))...(((.......(((...(((((......))))).[(...).((......]..))...)))........((((((((..[......)))))))).......(.((].[[[[)).)...)))......)..))))....)..............((....))....)).........((((....)))).............).....)))))))))).....(.((((((((((.......)))))))))).[.(.(........).).((((((....(((.((((((((((..(.(...(((....)))...).)...((....))...((......)).........)))))))))))))..((.(...((((((.....((((((.(((.((((....(((((.)))))....).)))...(((..(.((........)).).)))..).)).)))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((....(.(.(((((....(((...(((.(((.......))).)))..)).)....))))).)..)...))))))).))..(((((((.((......)).)))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(.(........(((...((..((...........))..))........................)))....).)..))))).))..........]]].)....))))))))))...)))))))(..((...(.)...))..)....))))))(.(((((((.........(((((.((....)).)))))......)))))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[.((((.((...(((...(((....)))...)))...))....(((..........)))..]((((((.((...((...((((....(((((.(((..(((((.((((......{{......))))(((((((.((..((.(.(.((....(.......)..)).)..).))..)))))))))...(((((....)))))....)))))...)))..)))))(..).....))))...))......)).)))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.[..).....)))))((((((((...))))))))(...).......(((((((((...(...........)...(((((((.....(((.....))).......))))))).]((((.(((.....((((..((.............(....).............)))))).....))).......((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.........((((.((((((..(((((.(.(.(((((.((((.((((.....))).)))))...((((((........))))))....))))).).)..)))))..(((......[)))((((((..........]))))))(.((...((((((..(.(((((.........)))))...).((.[.[[[)).....))))))...((.....((...{..)).....)).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))........)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).((((.(...(((...(((((((((((.}}.))))))...)))))...)))..)))))....((....((((.............))))....))..))))..]....)))))))..((.))....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))....)))))..) Crystal structure of the synergistic antibiotic pair lankamycin and lankacidin in complex with the large ribosomal subunit; RIBOSOMAL 23S RNA 3pio Y 120 3.2473 RF00001 URS000080E04E_243230 21282615 0003735 0005840 243230 acccccgugcccauagcacuguggaaccaccccaccccaugccgaacugggucgugaaacacagcagcgccaaugauacucggaccgcagggucccggaaaagucggucagcgcgggggu <<<<<<<<<<.....<<.<<<<<....<<<<<<<.............>>>>..>>>...>>>>>..>><<<.......<<.<<<<<....>>>>>.>>.......>>>..>>>>>>>>>> ((((((((((.....((.(((((....((((((....(.....)....)))..)))...)))))..)).((.......((.(((((....))))).)).......))...)))))))))) Crystal structure of the synergistic antibiotic pair lankamycin and lankacidin in complex with the large ribosomal subunit; 5S ribosomal RNA 3pip X 2644 3.45 RF02540,RF02541 URS000080DEF1_243230 21282615 0003735 0005840 243230 ggucaagauaguaaggguccacgguggaugcccuggcgcuggagccgaugaaggacgcgauuaccugcgaaaagccccgacgagcuggagauacgcuuugacucggggauguccgaauggggaaacccaccucguaagagguauccgcaaggaugggaacucagggaacugaaacaucucaguaccugaaggagaagaaagagaauucgauuccguuaguagcggcgagcgaacccggaucagcccaaucaagccgaaguggcuggaaagcuacaccucagaaggugagaguccuguaggcgaacgagaggucguuguucgugaaacgaugacugaauccgcgcggaccaccgcgcaaggcuaaauacucccagugaccgauagcgcauaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaagagaaccugaaaccguggacuuacaagcagucauggcaccuuaugcguguuauggcgugccuauugaagcaugagccggcgacuuagaccugacgugcgagcuuaaguugaaaaacggaggcggagcgaaagcgaguccgaauagggcggcauuaguacgucgggcuagacucgaaaccaggugagcuaagcaugaccagguugaaacccccgggggcggaggaccgaaccggugccugcugaaacagucucggaugaguuguguuuaggagugaaaagcuaaccgaaccuggagauagcuaguucuccccgaaauguauugagguacagccucggauguugaccauguccuguagagcacucacaaggcuaaaccuuaugaaacuccgaaggggcacgcguuuaguccgggagugaggcugcgagagcuaacuuccguagccgagagggaaacaacccagaccaucagcuaaggucccuaaaugaucgcucagugguuaaggaugugucgucgcgacagccaggagguuggcuuagagcagccacccuucaaagagugcguaauagcucacuggucgagugacgaugcgccgaaaaugaucggggcucaagugaucuaccgaagcuauggauucaacucguugucugguaggggagcguucaguccgcggagaagccauaccggaaggagugguggagccgacugaagugcggaugccggcaugaguaacgauaaaagaagugagaaucuucuucgccguaaggacaaggguuccuggggaagggucguccgcccagggaaagucgggaccuaaggugaggccgaacggcgcagccgauggacagcaggucaagauuccugcaccgaucaugugagugauggagggacgcauuacgcuauccaaugccaagcuauggcuaugcugguugguacgcucaagggcgaucgggucagaaaaucuaccgguugccucagacguaucgggagcuuccucggaagcgaaguuggaaacgcgacggugccaagaaaagcuucuaaacguugaaacaugauugcccguaccgcaaaccgacacagguguccgagugucaaugcacuaaggcgcgcgagagaacccucguuaaggaacuuugcaaucucaccccguaacuucggaagaagggguccccacgcuucgcguggggcgcagugaauaggcccaggcgacuguuuaccaaaaucacagcacucugccaacacgaacaguggacuauagggugugacgccugcccggugccggaaggucaaguggagcggugcaagcugcgaaaugaagccccggugaacggcuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaggcguaacgaucugggcgcugucucaacgagggacucggugaaauugaauuggcuguaaagaugcggccuacccguagcaggacgaaaagaccccguggagcuuuacuauagucuggcauugggauucgggucuuggauuucuaaccugaaaaaucacuuucggggaccgugcuuggcggguaguuugacuggggcggucgccucccaaaauguaacggaggcgcccaaaggucaccucaagacgguuggaaaucgucuguagagcgcaaagguagaagguggcuugacugcgagacugacacgucgagcagggaggaaacucgggcuuagugaaccggugguaccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagaguccauaucggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgcuacgggcgcaggagaauugaggggaguugcuccuaguacgagaggaccggagugaacggaccgcuggucucccugcugucguaccaacggcacaugcaggguagcuauguccggaacggauaaccgcugaaagcaucuaagcgggaagccagccccaagaugaguucucccacugagguaagacucccggaagaccaccggguuaagaggccaggcgugcacgcauagcaauguguucagcggacuggugcucaucagucgaggucuugacc <<<<<<<<......<<<<<<<<<<<.....<<..<<.<<<<<<<<<......<<<<<<.[...((.>>>.....<<<<<<...<<.))...]..>>......>>>>>>...>>>....<<<....>>><<<<<....>>>>><<<<....>>>>>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<......<<.....>>.....>>>>...<<<...<<..<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>....>>..<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..>>>......>>.>>>>>..>>..............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<.......>>>>>>>>>>...<............>.<<<<<<....<<<.<<<<<<<<<<..<<<...<<<....>>>...>>>...<<....>>...<........>.........>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<.....<<<<..>>>>......>>>...<<<..<.<<........>>.>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<...<<<<.<<<<<<...<<<...<<<.<<<<.....>>>>.>>>..>>.>...>>>>>>.>.>>>..>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<.....<<<<<.<<...<<<<......>>>>...>>.......<.<<......>>.>.>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><..<<<<..>>>>..>....>>>>>><<<<<<<<<.<<......<<<<<.<<....>>.>>>>>...>>.>>>>>>>.>>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<<..>>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<..<<...<<<<....<<<<..<<<..<<<<<.<<<<.<<...[[....>>>>>><<<<<<<.<<..<<<<.<<<<<...<<.....>>.>>>>>.>>>>..>>>>>>>>>...<<<<<....>>>>>....>>>>>...>>>...>>>>.........>>>>...>>......>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<...>>>>>>>>............<<<<<<<<<..<<...........>>..<<<<<<<.....<<<.....>>>......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>>.......<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<...>>>>>>>>>...<<<<<<........>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..>>>>..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<.<.<<.......>>..>>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<....<<<...<<<<<<<<<<<.]].>>>>>>...>>>>>...>>>..>>>>>....<<.<..<<<<<...........>>>>>...>>>..>>>>.......>>>>>>>..<<.>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>>> (..(((((......((((((((((.....(((..((((((((((((.......(((((.....[[.))).....((((((...((.]]......))......))))))...)).....(((....)))(((((....)))))((((....))))))...((((((.........[.........))))).).........((....))...((((.........]..........))))...(((...((..(((...(((((......)))))[[(...).((......]].))...)))....))..(((((((((.[.....))))))))).......(.((].[[[[)).)...)))......)).)))))).))..............((....))....)).........((((....))))..(......)...).....)))))))))).....(.(((((((((.........))))))))).[.(.(........).).((((((....(((.((((((((((...((...(((....)))...))....((....))....(.......).........)))))))))))))..((.(...((((((.....(((((((((..((((....((((()))))....)[)))...((...(.((........)).)..))....))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((...((((.((((((...(((...(((.(((.......))).)))..)).)...)))))).).)))..))))))).))..(((((((.((......)).)))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(.((((((.(..{..(((..(((..((..........))..))).....(..............)..)))....).)))))).).))..........]]].)....))))))))))...)))))))(..((......))..)....))))))(.(((((((.........(((((.((....)).)))))......)))))))..).....))))))(......((.....(.((((.......)))).)((((....((((..((..((((((....((.....))..)))))....[.((((..(...(((...(((....)))...)))...)....(((((........))))).]((((((.((..((...((((.....((((.(((..((((...(((.((...{{....))))).(((((((.((..((.(.(((((...((.....)).))))).).))..)))))))))...(((((....))))).....))))...)))..)))).(..).....))))...))......)).)))))))))).))).....((......)).)))).(((((....)))))..))))..((((....(((((((...........(........((((....(....).....)))).((((((((...))))))))(...).......(((((((((.].(...........)....((((((.....(.(.....).)......))))))...((((.(((..((.((((..(.....((...((((......))))...)).....)))))...))))).......(...........((((.........)))).....)....))))...)).))))))).).......))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((...)))))))))...((((((........))))))....))))).)))..)))))..(((......[)))((((((..........]))))))(..(...(((((((.(.(((((.........)))))...).((.[.[[[))....)))))))...((....(((...{..)))....)).(((....))).).]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((.((.(.((((((...((.......))...))))))...)))..).).......(((.((((((..(.(.(((((......)))))...).).(((((.....))))).....)))))..)...))).......((.((((....))).).))....)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((..(.....(...(((((((((((.}}.))))))...)))))...)....).)))....((....((((.....}.......))))....))..))))..]....)))))))..((.))....(..((((((.......)))))....((((((((.(((.....((((....))))....)))..))))).)))...)..)....)))))..) Crystal structure of the synergistic antibiotic pair lankamycin and lankacidin in complex with the large ribosomal subunit; RIBOSOMAL 23S RNA 3pip Y 120 3.45 RF00001 URS000080E04E_243230 21282615 0003735 0005840 243230 acccccgugcccauagcacuguggaaccaccccaccccaugccgaacugggucgugaaacacagcagcgccaaugauacucggaccgcagggucccggaaaagucggucagcgcgggggu <<<<<<<<<<.....<<.<<<<<....<<<<<<<.............>>>>..>>>...>>>>>..>><<<.......<<.<<<<<....>>>>>.>>.......>>>..>>>>>>>>>> ((((((((((.....(..(((((....(((((((...(.....)...))))..)))...)))))...).((.......((.((.((....)).)).)).......))...)))))))))) Crystal structure of the synergistic antibiotic pair lankamycin and lankacidin in complex with the large ribosomal subunit; 5S ribosomal RNA 3pla G 35 3.15 URS000080DD2E_32630 21270896 32630 gggagucuugugaugaaacacucauggucugaaga ................................... ................................... Crystal structure of a catalytically active substrate-bound box C/D RNP from Sulfolobus solfataricus; C/D guide RNA 3pla H 32 3.15 URS000080DD2E_32630 21270896 32630 ugugaugaaacacucauggucugaagacuccc ................................ ................................ Crystal structure of a catalytically active substrate-bound box C/D RNP from Sulfolobus solfataricus; C/D guide RNA 3pla I 10 3.15 URS000080E062_32630 21270896 32630 ccaugagugu .......... .......... Crystal structure of a catalytically active substrate-bound box C/D RNP from Sulfolobus solfataricus; RNA (5'-R(*CP*CP*AP*UP*GP*AP*GP*UP*GP*U)-3') 3pla J 10 3.15 URS000080E062_32630 21270896 32630 ccaugagugu .......... .......... Crystal structure of a catalytically active substrate-bound box C/D RNP from Sulfolobus solfataricus; RNA (5'-R(*CP*CP*AP*UP*GP*AP*GP*UP*GP*U)-3') 3pla N 31 3.15 URS000080DD2E_32630 21270896 32630 ucuugugaugaaacacucauggucugaagac ............................... ............................... Crystal structure of a catalytically active substrate-bound box C/D RNP from Sulfolobus solfataricus; C/D guide RNA 3pla O 10 3.15 URS000080E062_32630 21270896 32630 ccaugagugu .......... .......... Crystal structure of a catalytically active substrate-bound box C/D RNP from Sulfolobus solfataricus; RNA (5'-R(*CP*CP*AP*UP*GP*AP*GP*UP*GP*U)-3') 3ptx R 45 3.0 URS000080E1AF_32630 21177817 32630 aaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa ............................................. ............................................. Crystal Structure of a vesicular stomatitis virus nucleocapsid-polyA complex; RNA (45-MER) 3pu0 R 45 3.09 URS000080E318_32630 21177817 32630 ccccccccccccccccccccccccccccccccccccccccccccc ............................................. ............................................. Crystal Structure of a vesicular stomatitis virus nucleocapsid-polyC complex; RNA (45-MER) 3pu1 R 45 3.14 URS000080E13B_32630 21177817 32630 ggggggggggggggggggggggggggggggggggggggggggggg ............................................. ............................................. Crystal Structure of a vesicular stomatitis virus nucleocapsid-polyG complex; RNA (45-MER) 3pu4 R 45 3.0 URS000080E17E_32630 21177817 32630 uuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuu ............................................. ............................................. Crystal Structure of a vesicular stomatitis virus nucleocapsid-polyU complex; RNA (45-MER) 3q1q B 347 3.8 RF00010 URS000080E347_2336 21076397 3.1.26.5 0004526 0008033 0030680 2336 ggagaggagcaggcggucgcgggggcgcacaccugcgcuucccgaggaaaguccggacucuggagcggggugccggguaacgcccgggaggggugacccucggacagggccauagagaagaagaccgcccggggggaaacuuccgggcaaggguggaacggugggguaagagcccaccagcgucggggcaacccggcggcuuggcaacccccaccuggagcaaggccaagcaggggguugggucgcucccccuauucccccggguuggccgcuugaggugugcgguaacgcacaccccagauugaugaccgcccacgacagaauccggcuuaugcuccucucccgug <<<<<<<<<<..<<<<<<.<<<<<<<<<<....>>>>>.>>>>>.....{{.(((((((((<<<<<<<<<<<<<<<<.....>>>>><<<<<....>>>>><<...<<<<<.............<<<<<<<<<<<....>>>>>>>>>..>>.......<<<<<<.......>>>>>>.<<<<<<<<....>>>>>>>.>..>>>..>>>>>>>>>))))...[[[[.....(((((..(((.>>>>>>.)))...))))).....]]]]......<<<<<<<<....>>>>>>>>..........>>>>>>...........)))))}}...>>>>>>>>>>.... ((((((((((..((((((.((((((((((....))))).))))).{...[[.[[[[[(((([[[[[.((((((((((.....)))))(((((....)))))((...(((((.............(((((((((((....)))))))))..)).......((((((.......))))))(.(((((((....)))))))..).)))..)))))))))))))...((((.....(((((..(((..]]]]].)))...))))).....))))......((((((((....))))))))..........))))))......}....]]]]]]]...)))))))))).... Structure of a Bacterial Ribonuclease P Holoenzyme in Complex with tRNA; RNase P RNA 3q1q C 86 3.8 RF00005 URS000080DFE4_2336 21076397 0030533 0006412 2336 ggccagguagcucaguugguagagcacuggauaugggcacccccuaaguccaggugucggcgguucgauuccgccccuggccacca <<<<<<<..<<<<........>>>>.<<<<<<..<<<....>>>...>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((((..(((....)))...)))))).....(((((..]....)))))))))))).... Structure of a Bacterial Ribonuclease P Holoenzyme in Complex with tRNA; TRNA (PHE) 3q1r B 347 4.21 RF00010 URS000080E347_2336 21076397 3.1.26.5 0004526 0008033 0030680 2336 ggagaggagcaggcggucgcgggggcgcacaccugcgcuucccgaggaaaguccggacucuggagcggggugccggguaacgcccgggaggggugacccucggacagggccauagagaagaagaccgcccggggggaaacuuccgggcaaggguggaacggugggguaagagcccaccagcgucggggcaacccggcggcuuggcaacccccaccuggagcaaggccaagcaggggguugggucgcucccccuauucccccggguuggccgcuugaggugugcgguaacgcacaccccagauugaugaccgcccacgacagaauccggcuuaugcuccucucccgug <<<<<<<<<<..<<<<<<.<<<<<<<<<<....>>>>>.>>>>>.....{{.(((((((((<<<<<<<<<<<<<<<<.....>>>>><<<<<....>>>>><<...<<<<<.............<<<<<<<<<<<....>>>>>>>>>..>>.......<<<<<<.......>>>>>>.<<<<<<<<....>>>>>>>.>..>>>..>>>>>>>>>))))...[[[[.....(((((..(((.>>>>>>.)))...))))).....]]]]......<<<<<<<<....>>>>>>>>..........>>>>>>...........)))))}}...>>>>>>>>>>.... ((((((((((..((((((.((((((((((....))))).))))).{...[[.[[[[[(((([[[[[.((((((((((.....)))))(((((....)))))((...(((((.............(((((((((((....)))))))))..)).......((((((.......))))))(.(((((((....)))))))..).)))..)))))))))))))...((((.....(((((..(((..]]]]].)))...))))).....))))......((((((((....))))))))..........))))))......}....]]]]]]]...)))))))))).... Crystal structure of a bacterial RNase P holoenzyme in complex with TRNA and in the presence of 5' leader; RNase P RNA 3q1r C 86 4.21 RF00005 URS000080DFE4_2336 21076397 0030533 0006412 2336 ggccagguagcucaguugguagagcacuggauaugggcacccccuaaguccaggugucggcgguucgauuccgccccuggccacca <<<<<<<..<<<<........>>>>.<<<<<<..<<<....>>>...>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((((..(((....)))...)))))).....(((((..]....)))))))))))).... Crystal structure of a bacterial RNase P holoenzyme in complex with TRNA and in the presence of 5' leader; TRNA (PHE) 3qjl X 12 2.7009 URS000080DF86_32630 32630 guuacaauaaga ............ ............ One RAMP protein binding different RNA substrates; RNA (5'-R(*GP*UP*UP*AP*CP*AP*AP*UP*AP*AP*GP*A)-3') 3qjl R 12 2.7009 URS000080DF86_32630 32630 guuacaauaaga ............ ............ One RAMP protein binding different RNA substrates; RNA (5'-R(*GP*UP*UP*AP*CP*AP*AP*UP*AP*AP*GP*A)-3') 3r1d A 11 1.45 URS00021ED9B0_32630 21596781 32630 gcngcggcggc ........... ........... Crystal structure of GC(8BrG)GCGGCGGC duplex; RNA (5'-R(*GP*CP*(GRB)P*GP*CP*GP*GP*CP*GP*GP*C)-3') 3r1d B 11 1.45 URS00021ED9B0_32630 21596781 32630 gcngcggcggc ........... ........... Crystal structure of GC(8BrG)GCGGCGGC duplex; RNA (5'-R(*GP*CP*(GRB)P*GP*CP*GP*GP*CP*GP*GP*C)-3') 3r1d C 11 1.45 URS00021ED9B0_32630 21596781 32630 gcngcggcggc ........... ........... Crystal structure of GC(8BrG)GCGGCGGC duplex; RNA (5'-R(*GP*CP*(GRB)P*GP*CP*GP*GP*CP*GP*GP*C)-3') 3r1d D 11 1.45 URS00021ED9B0_32630 21596781 32630 gcngcggcggc ........... ........... Crystal structure of GC(8BrG)GCGGCGGC duplex; RNA (5'-R(*GP*CP*(GRB)P*GP*CP*GP*GP*CP*GP*GP*C)-3') 3r1d E 11 1.45 URS00021ED9B0_32630 21596781 32630 gcngcggcggc ........... ........... Crystal structure of GC(8BrG)GCGGCGGC duplex; RNA (5'-R(*GP*CP*(GRB)P*GP*CP*GP*GP*CP*GP*GP*C)-3') 3r1h C 130 3.15 URS000080E303_32630 21857665 32630 ngaacacuauacuacuggauaaucaaagacaaaucugcccgaaggguuugagaacauacccauugcacuccggguaugcagagguggcagccuccgguggguuaaaacccaacguucucaacaauagugn (...<<<<<<.)......................(((((........<<<<<<<<<<<<<<..........>>>>>>>..<<<<.)))))>>>><<.<<<<<....>>>>>.>>>>>>>>>..>>>>>>. [...((((((.]......................[[[[[(...).(.((((((((((((((..........)))))))..((((.]]]]]))))((.((((......)))).)))))))))).)))))). Crystal structure of the Class I ligase ribozyme-substrate preligation complex, C47U mutant, Ca2+ bound; Class I ligase ribozyme 3r1h F 130 3.15 URS000080E303_32630 21857665 32630 ngaacacuauacuacuggauaaucaaagacaaaucugcccgaaggguuugagaacauacccauugcacuccggguaugcagagguggcagccuccgguggguuaaaacccaacguucucaacaauagugn (...<<<<<<.)......................(((((........<<<<<<<<<<<<<<..........>>>>>>>..<<<<.)))))>>>><<.<<<<<....>>>>>.>>>>>>>>>..>>>>>>. [...((((((.]......................[[[[[(...).(.((((((((((((((..........)))))))..((((.]]]]]))))((.((((......)))).)))))))))).)))))). Crystal structure of the Class I ligase ribozyme-substrate preligation complex, C47U mutant, Ca2+ bound; Class I ligase ribozyme 3r1l C 130 3.125 URS000080E303_32630 21857665 32630 ngaacacuauacuacuggauaaucaaagacaaaucugcccgaaggguuugagaacauacccauugcacuccggguaugcagagguggcagccuccgguggguuaaaacccaacguucucaacaauagugn (...<<<<<<.)......................(((((........<<<<<<<<<<<<<<..........>>>>>>>..<<<<.)))))>>>><<.<<<<<....>>>>>.>>>>>>>>>..>>>>>>. [...((((((.]......................[[[[[(...).(.((((((((((((((..........)))))))..((((.]]]]]))))((.((((......)))).)))))))))).)))))). Crystal structure of the Class I ligase ribozyme-substrate preligation complex, C47U mutant, Mg2+ bound; Class I ligase ribozyme 3r1l F 130 3.125 URS000080E303_32630 21857665 32630 ngaacacuauacuacuggauaaucaaagacaaaucugcccgaaggguuugagaacauacccauugcacuccggguaugcagagguggcagccuccgguggguuaaaacccaacguucucaacaauagugn (...<<<<<<.)......................(((((........<<<<<<<<<<<<<<..........>>>>>>>..<<<<.)))))>>>><<.<<<<<....>>>>>.>>>>>>>>>..>>>>>>. [...((((((.]......................[[[[[(...).(.((((((((((((((..........)))))))..((((.]]]]]))))((.((((......)))).)))))))))).)))))). Crystal structure of the Class I ligase ribozyme-substrate preligation complex, C47U mutant, Mg2+ bound; Class I ligase ribozyme 3r2d R 12 2.199 URS000080DF91_63363 21652641 63363 ggcuccuuggca ............ ............ Crystal Structure of Antitermination Factors NusB and NusE in complex with dsRNA; 5'-R(*GP*GP*CP*UP*CP*CP*UP*UP*GP*GP*CP*A)-3' 3s4p A 21 2.56 URS000080DF2F_32630 21905229 32630 gcgucacaccggugaagucgc ..................... ..................... Crystal structure of the bacterial ribosomal decoding site complexed with an amphiphilic paromomycin O2''-ether analogue; RNA (5'-R(P*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*C)-3') 3s4p B 21 2.56 URS000080DF2F_32630 21905229 32630 gcgucacaccggugaagucgc ..................... ..................... Crystal structure of the bacterial ribosomal decoding site complexed with an amphiphilic paromomycin O2''-ether analogue; RNA (5'-R(P*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*C)-3') 3siv C 32 3.304 URS000080E2ED_9606 21784869 9606 uacuguccaaugagcgcauagugagggcagua ................................ ................................ Structure of a hPrp31-15.5K-U4atac 5' stem loop complex, dimeric form; U4atac snRNA 3siv F 32 3.304 URS000080E2ED_9606 21784869 9606 uacuguccaaugagcgcauagugagggcagua ................................ ................................ Structure of a hPrp31-15.5K-U4atac 5' stem loop complex, dimeric form; U4atac snRNA 3siv I 32 3.304 URS000080E2ED_9606 21784869 9606 uacuguccaaugagcgcauagugagggcagua ................................ ................................ Structure of a hPrp31-15.5K-U4atac 5' stem loop complex, dimeric form; U4atac snRNA 3siv L 32 3.304 URS000080E2ED_9606 21784869 9606 uacuguccaaugagcgcauagugagggcagua ................................ ................................ Structure of a hPrp31-15.5K-U4atac 5' stem loop complex, dimeric form; U4atac snRNA 3sj2 A 19 1.36 URS000080E259_32630 21766409 32630 uugggccggcggcgggucc ................... ................... A Crystal Structure of a Model of the Repeating r(CGG) Transcript Found in Fragile X Syndrome; RNA (5'-R(*UP*UP*GP*GP*GP*CP*CP*GP*GP*CP*GP*GP*CP*GP*GP*GP*UP*CP*C)-3') 3sj2 B 17 1.36 URS000080DE63_32630 21766409 32630 gggccggcggcgggucc ................. ................. A Crystal Structure of a Model of the Repeating r(CGG) Transcript Found in Fragile X Syndrome; RNA (5'-R(P*GP*GP*GP*CP*CP*GP*GP*CP*GP*GP*CP*GP*GP*GP*UP*CP*C)-3') 3ski A 68 2.3 RF01510 URS000080DE91_2151 21841796 0032546 0031554 2151 ngccuuauacaggguagcauaaugggcuacugaccccgccuucaaaccuauuuggagacuauaaggun <<<<<<<<<...<<<<<<.....((>>>>>>........<<<<<<<))..>>>>>>>..>>>>>>>>> ((((((((((..((((((.....[[))))))[.....)](((((((]]..)))))))..))))))))) Crystal structure of the 2'- Deoxyguanosine riboswitch bound to 2'-deoxyguanosine; RNA (68-MER) 3ski B 68 2.3 RF01510 URS000080DE91_2151 21841796 0032546 0031554 2151 ggccuuauacaggguagcauaaugggcuacugaccccgccuucaaaccuauuuggagacuauaaggun <<<<<<<<<...<<<<<<.....((>>>>>>........<<<<<<<))..>>>>>>>..>>>>>>>>> ((((((((((..((((((.....[[))))))[.....)](((((((]]..)))))))..))))))))) Crystal structure of the 2'- Deoxyguanosine riboswitch bound to 2'-deoxyguanosine; RNA (68-MER) 3syw A 19 1.57 URS000080DDF5_32630 21988728 32630 uugggccugcugcuggucc ................... ................... Crystal Structure of the Triplet Repeat in Myotonic Dystrophy Reveals Heterogeneous 1x1 Nucleotide UU Internal Loop Conformations; RNA (5'-R(*UP*UP*GP*GP*GP*CP*CP*UP*GP*CP*UP*GP*CP*UP*GP*GP*UP*CP*C)-3') 3syw B 19 1.57 URS000080DDF5_32630 21988728 32630 uugggccugcugcuggucc ................... ................... Crystal Structure of the Triplet Repeat in Myotonic Dystrophy Reveals Heterogeneous 1x1 Nucleotide UU Internal Loop Conformations; RNA (5'-R(*UP*UP*GP*GP*GP*CP*CP*UP*GP*CP*UP*GP*CP*UP*GP*GP*UP*CP*C)-3') 3szx A 19 2.204 URS000080DDF5_32630 21988728 32630 uugggccugcugcuggucc ................... ................... Crystal Structure of the Triplet Repeat in Myotonic Dystrophy Reveals Heterogeneous 1x1 Nucleotide UU Internal Loop Conformations; RNA (5'-R(P*UP*UP*GP*GP*GP*CP*CP*UP*GP*CP*UP*GP*CP*UP*GP*GP*UP*CP*C)-3') 3szx B 19 2.204 URS000080DDF5_32630 21988728 32630 uugggccugcugcuggucc ................... ................... Crystal Structure of the Triplet Repeat in Myotonic Dystrophy Reveals Heterogeneous 1x1 Nucleotide UU Internal Loop Conformations; RNA (5'-R(P*UP*UP*GP*GP*GP*CP*CP*UP*GP*CP*UP*GP*CP*UP*GP*GP*UP*CP*C)-3') 3t1h A 1513 3.11 RF00177,RF01959,RF01960 URS000080E11D_300852 22227389 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucacuuucu ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<<.....>>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<.<..<<<<<<<.<..<<<......>>>.....>.>>>>>>>...>.......<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<.......<<<<<<...<<<<<<<....>>>>>>>....<<.......>>...>>>>>>..<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<....<.......>.>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<...<<<<....>>>>...>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.....)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(..((...(((((....)))).))).).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(.(.(..(...(..(((....)))..)....(.(.......))...).).).)).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((.......((.......))......)))))))..(..((((......)))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...((((((......(((...(..((((....))))..).....)))......))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(.(..((((((((.((((...(.((((....(((....))).)))).)..)))).))))))))..).).))))..).))...)..)..(((((((((....)))))))))}........... Structure of the Thermus thermophilus 30S ribosomal subunit complexed with a human anti-codon stem loop (HASL) of transfer RNA lysine 3 (tRNALys3) bound to an mRNA with an AAA-codon in the A-site and Paromomycin; 16s rRNA 3t1h X 11 3.11 URS000080DD95_9606 22227389 9606 gacunuunauc <<.......>> (.........) Structure of the Thermus thermophilus 30S ribosomal subunit complexed with a human anti-codon stem loop (HASL) of transfer RNA lysine 3 (tRNALys3) bound to an mRNA with an AAA-codon in the A-site and Paromomycin; tRNA ASL human Lys3 3t1y A 1513 2.8 RF00177,RF01959,RF01960 URS000080E11D_300852 22227389 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucacuuucu ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<<.....>>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<.<..<<<<<<<.<..<<<......>>>.....>.>>>>>>>...>.......<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<.<..<<<<<<<....>>>>>>>...<<<<....>>>>...>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.....)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((.(....).)).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((.....)))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((.(((.(...((((((....))))))......((....)).....)))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((.......(((.....)))......)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Structure of the Thermus thermophilus 30S ribosomal subunit complexed with a human anti-codon stem loop (HASL) of transfer RNA Lysine 3 (TRNALYS3) bound to an mRNA with an AAG-codon in the A-site and paromomycin; 16S rRNA 3t1y X 11 2.8 URS000080DD95_9606 22227389 9606 gacunuunauc <<.......>> (.........) Structure of the Thermus thermophilus 30S ribosomal subunit complexed with a human anti-codon stem loop (HASL) of transfer RNA Lysine 3 (TRNALYS3) bound to an mRNA with an AAG-codon in the A-site and paromomycin; tRNA ASL human Lys3 3td0 A 21 1.6 URS000080E022_32630 22110016 32630 gcgucgcgncgacgaagucgc ..................... ..................... Crystal structure of the bacterial A1408G-mutant and the protozoa cytoplasmic ribosomal decoding site; RNA (5'-R(*UP*UP*GP*CP*GP*UP*CP*GP*CP*GP*(5BU)P*CP*GP*AP*CP*GP*AP*AP*GP*UP*CP*GP*C)-3') 3td0 B 23 1.6 URS000080E022_32630 22110016 32630 uugcgucgcgncgacgaagucgc ....................... ....................... Crystal structure of the bacterial A1408G-mutant and the protozoa cytoplasmic ribosomal decoding site; RNA (5'-R(*UP*UP*GP*CP*GP*UP*CP*GP*CP*GP*(5BU)P*CP*GP*AP*CP*GP*AP*AP*GP*UP*CP*GP*C)-3') 3td1 A 22 2.1 URS000080E022_32630 22110016 32630 ugcgucgcgncgacgaagucgc ...................... ...................... Crystal structure of the bacterial A1408G-mutant and the protozoa cytoplasmic ribosomal decoding site in complex with geneticin; RNA (5'-R(*UP*UP*GP*CP*GP*UP*CP*GP*CP*GP*(5BU)P*CP*GP*AP*CP*GP*AP*AP*GP*UP*CP*GP*C)-3') 3td1 B 23 2.1 URS000080E022_32630 22110016 32630 uugcgucgcgncgacgaagucgc ....................... ....................... Crystal structure of the bacterial A1408G-mutant and the protozoa cytoplasmic ribosomal decoding site in complex with geneticin; RNA (5'-R(*UP*UP*GP*CP*GP*UP*CP*GP*CP*GP*(5BU)P*CP*GP*AP*CP*GP*AP*AP*GP*UP*CP*GP*C)-3') 3tzr A 20 2.212 URS000080E0FD_3052230 3052230 cgaggaacuacugucuuccc .................... .................... Structure of a Riboswitch-like RNA-ligand complex from the Hepatitis C Virus Internal Ribosome Entry Site; 5'-R(*CP*GP*AP*GP*GP*AP*AP*CP*UP*AP*CP*UP*GP*UP*CP*UP*UP*CP*CP*C)-3' 3tzr B 16 2.212 URS000080DF8B_3052230 3052230 ggucgugcagccucgg ................ ................ Structure of a Riboswitch-like RNA-ligand complex from the Hepatitis C Virus Internal Ribosome Entry Site; 5'-R(*GP*GP*UP*CP*GP*UP*GP*CP*AP*GP*CP*CP*UP*CP*GP*G)-3' 3ucu R 92 2.8 RF03167,RF01051 URS000080E2D1_666 22148472 0035438 666 ngucacgcacagggcaaaccauucgaaagagugggacgcaaagccuccggccuaaaccauugcacuccgguagguagcgggguuaccgaugg .....<.......<<...<<<<<<....>>>>>>...>>...<<<.<<<<<<<..<<<..........>>>>>>>..>>>>>>....>.... ...(.((......((...((((((....))))))..[))...(((.((((((((..((..........))))))).]))))))...))...) The c-di-GMP-I riboswitch bound to pGpG; RNA (92-MER) 3ucz R 92 2.8 RF03167,RF01051 URS000080E2D1_666 22148472 0035438 666 ngucacgcacagggcaaaccauucgaaagagugggacgcaaagccuccggccuaaaccauugcacuccgguagguagcgggguuaccgaugg .....<.......<<...<<<<<<....>>>>>>...>>...<<<.<<<<<<<..<<<..........>>>>>>>..>>>>>>....>.... ...(.((......((...((((((....))))))..[))...(((.((((((((..((..........))))))).]))))))...))...) The c-di-GMP-I riboswitch bound to GpG; RNA (92-MER) 3ud3 R 92 3.1 RF03167,RF01051 URS000080E118_666 22148472 0035438 666 ngucacgcacagggcaaaccauucgaaagagugggacgcaaagccuccggccuaaaccauugcacuccgguagguagcgggguuaucgaugg .....<.......<<...<<<<<<....>>>>>>...>>...<<<.<<<<<<<..<<<..........>>>>>>>..>>>>>>....>.... ...(.((......((...((((((....))))))..[))...(((.((((((((..((..........))))))).]))))))...))...) The C92U mutant c-di-GMP-I riboswitch bound to pGpA; RNA (92-MER) 3ud4 R 92 2.7 RF03167,RF01051 URS000080E118_666 22148472 0035438 666 ngucacgcacagggcaaaccauucgaaagagugggacgcaaagccuccggccuaaaccauugcacuccgguagguagcgggguuaucgaugg .....<<......<<...<<<<<<....>>>>>>...>>...<<<.<<<<<<<..<<<..........>>>>>>>..>>>>>>...>>.... ...(.((......((...((((((....))))))..[))...(((.(((((((...((..........)).)))).]))))))...))...) The C92U mutant c-di-GMP-I riboswitch bound to GpA; RNA (92-MER) 3vjr B 36 2.4 URS000080E2A0_32630 22923517 32630 gggggcuaagcgguucgaucccgcuuagcuccacca .<<<<<<<<<<<<.......>>>>>>>>>>>>.... .((((((((((((.......)))))))))))).... Crystal structure of Peptidyl-tRNA hydrolase from Escherichia coli in complex with the CCA-acceptor-T[PSI]C domain of tRNA; tRNA CCA-acceptor 3vjr D 36 2.4 URS000080E2A0_32630 22923517 32630 gggggcuaagcgguucgaucccgcuuagcuccacca .<<<<<<<<<<<<.......>>>>>>>>>>>>.... .((((((((((((.......)))))))))))).... Crystal structure of Peptidyl-tRNA hydrolase from Escherichia coli in complex with the CCA-acceptor-T[PSI]C domain of tRNA; tRNA CCA-acceptor 3vyx B 10 2.29 URS000080DF81_32630 23361462 32630 gcgcgcgcgc .......... .......... Structural insights into RISC assembly facilitated by dsRNA binding domains of human RNA helicase (DHX9); RNA (5'-R(P*GP*CP*GP*CP*GP*CP*GP*CP*GP*C)-3') 3vyx C 10 2.29 URS000080DF81_32630 23361462 32630 gcgcgcgcgc .......... .......... Structural insights into RISC assembly facilitated by dsRNA binding domains of human RNA helicase (DHX9); RNA (5'-R(P*GP*CP*GP*CP*GP*CP*GP*CP*GP*C)-3') 3vyy C 10 2.9 URS000080DF81_32630 23361462 32630 gcgcgcgcgc .......... .......... Structural insights into RISC assembly facilitated by dsRNA binding domains of human RNA helicase A (DHX9); RNA (5'-R(*GP*CP*GP*CP*GP*CP*GP*CP*GP*C)-3') 3vyy D 10 2.9 URS000080DF81_32630 23361462 32630 gcgcgcgcgc .......... .......... Structural insights into RISC assembly facilitated by dsRNA binding domains of human RNA helicase A (DHX9); RNA (5'-R(*GP*CP*GP*CP*GP*CP*GP*CP*GP*C)-3') 3vyy E 10 2.9 URS000080DF81_32630 23361462 32630 gcgcgcgcgc .......... .......... Structural insights into RISC assembly facilitated by dsRNA binding domains of human RNA helicase A (DHX9); RNA (5'-R(*GP*CP*GP*CP*GP*CP*GP*CP*GP*C)-3') 3vyy F 10 2.9 URS000080DF81_32630 23361462 32630 gcgcgcgcgc .......... .......... Structural insights into RISC assembly facilitated by dsRNA binding domains of human RNA helicase A (DHX9); RNA (5'-R(*GP*CP*GP*CP*GP*CP*GP*CP*GP*C)-3') 3vyy G 10 2.9 URS000080DF81_32630 23361462 32630 gcgcgcgcgc .......... .......... Structural insights into RISC assembly facilitated by dsRNA binding domains of human RNA helicase A (DHX9); RNA (5'-R(*GP*CP*GP*CP*GP*CP*GP*CP*GP*C)-3') 3wbm X 25 2.0 URS000080DFA7_32630 24307170 32630 gguaagagcacccgacugcucuucc ......................... ......................... Crystal Structure of protein-RNA complex; RNA (25-MER) 3wbm Y 25 2.0 URS000080DFA7_32630 24307170 32630 gguaagagcacccgacugcucuucc ......................... ......................... Crystal Structure of protein-RNA complex; RNA (25-MER) 3wru A 21 2.3 URS000080DDE4_32630 25019242 32630 gcgucacgccggcgaagucgc ..................... ..................... Crystal structure of the bacterial ribosomal decoding site in complex with synthetic aminoglycoside with F-HABA group; RNA (5'-R(*UP*UP*GP*CP*GP*UP*CP*AP*CP*GP*CP*CP*GP*GP*CP*GP*AP*AP*GP*UP*CP*GP*C)-3') 3wru B 21 2.3 URS000080DDE4_32630 25019242 32630 gcgucacgccggcgaagucgc ..................... ..................... Crystal structure of the bacterial ribosomal decoding site in complex with synthetic aminoglycoside with F-HABA group; RNA (5'-R(*UP*UP*GP*CP*GP*UP*CP*AP*CP*GP*CP*CP*GP*GP*CP*GP*AP*AP*GP*UP*CP*GP*C)-3') 3zc0 M 15 2.982 URS000080DD91_32630 23353787 32630 uucgacgcgucgaau ............... ............... Structure of AfC3PO - duplex RNA complex; 5'-R(*UP*UP*CP*GP*AP*CP*GP*CP*GP*UP*CP*GP*AP*AP*UP*U)-3' 3zc0 N 15 2.982 URS000080DD91_32630 23353787 32630 uucgacgcgucgaau ............... ............... Structure of AfC3PO - duplex RNA complex; 5'-R(*UP*UP*CP*GP*AP*CP*GP*CP*GP*UP*CP*GP*AP*AP*UP*U)-3' 3zc0 O 15 2.982 URS000080DD91_32630 23353787 32630 uucgacgcgucgaau ............... ............... Structure of AfC3PO - duplex RNA complex; 5'-R(*UP*UP*CP*GP*AP*CP*GP*CP*GP*UP*CP*GP*AP*AP*UP*U)-3' 3zd4 A 43 2.2 URS000080DDC7_32630 25195740 32630 ngauguacuaccagcugaugagucccaaauaggacaaaacgcc .....................<<<<......>>>>........ ..............(....).((((......))))........ Full-Length Hammerhead Ribozyme with G12A substitution at the general base position; HAMMERHEAD RIBOZYME, ENZYME STRAND 3zd4 B 20 2.2 URS000080DDC4_32630 25195740 32630 ggcguncugguauccaaucc .................... .................... Full-Length Hammerhead Ribozyme with G12A substitution at the general base position; HAMMERHEAD RIBOZYME, SUBSTRATE STRAND 3zd5 A 43 2.2 RF00163 URS000080DF75_6183 16859740 3.1.-.- 0004540 6183 ngauguacuaccagcugaugagucccaaauaggacgaaacgcc .....................<<<<......>>>>........ ..............(....).((((......))))........ THE 2.2 A STRUCTURE OF A FULL-LENGTH CATALYTICALLY ACTIVE HAMMERHEAD RIBOZYME; HAMMERHEAD RIBOZYME, ENZYME STRAND 3zd5 B 20 2.2 URS000080DDC4_6183 16859740 6183 ggcguncuggnauccaancc .................... .................... THE 2.2 A STRUCTURE OF A FULL-LENGTH CATALYTICALLY ACTIVE HAMMERHEAD RIBOZYME; HAMMERHEAD RIBOZYME, SUBSTRATE STRAND 3zd6 C 10 2.8 URS000080DF81_32630 23897087 32630 gcgcgcgcgc .......... .......... Snapshot 1 of RIG-I scanning on RNA duplex; RNA DUPLEX 3zd6 D 10 2.8 URS000080DF81_32630 23897087 32630 gcgcgcgcgc .......... .......... Snapshot 1 of RIG-I scanning on RNA duplex; RNA DUPLEX 3zd7 C 10 2.5 URS000080DF81_32630 23897087 32630 gcgcgcgcgc .......... .......... Snapshot 3 of RIG-I scanning on RNA duplex; RNA DUPLEX 3zd7 D 10 2.5 URS000080DF81_32630 23897087 32630 gcgcgcgcgc .......... .......... Snapshot 3 of RIG-I scanning on RNA duplex; RNA DUPLEX 3zp8 A 43 1.55 RF00163 URS000080DF75_32630 23711504 3.1.-.- 0004540 32630 ngauguacuaccagcugaugagucccaaauaggacgaaacgcc .....................<<<<......>>>>........ ..............(....).((((......))))........ HIGH-RESOLUTION FULL-LENGTH HAMMERHEAD RIBOZYME; HAMMERHEAD RIBOZYME, ENZYME STRAND 3zp8 B 20 1.55 URS000080DDC4_32630 23711504 32630 ggcguncugguauccaaucc .................... .................... HIGH-RESOLUTION FULL-LENGTH HAMMERHEAD RIBOZYME; HAMMERHEAD RIBOZYME, SUBSTRATE STRAND 405d A 16 2.5 URS000080DF42_32630 9799637 32630 gcagacuuaaaucugc ................ ................ STRUCTURE OF A 16-MER RNA DUPLEX R(GCAGACUUAAAUCUGC)2 WITH WOBBLE LIKE A.C MISMATCHES; RNA (5'-R(*GP*CP*AP*GP*AP*CP*UP*UP*AP*AP*AP*UP*CP*UP*GP*C)-3') 405d B 16 2.5 URS000080DF42_32630 9799637 32630 gcagacuuaaaucugc ................ ................ STRUCTURE OF A 16-MER RNA DUPLEX R(GCAGACUUAAAUCUGC)2 WITH WOBBLE LIKE A.C MISMATCHES; RNA (5'-R(*GP*CP*AP*GP*AP*CP*UP*UP*AP*AP*AP*UP*CP*UP*GP*C)-3') 406d A 17 1.8 URS000080E2A1_32630 9917398 32630 caccggaugguncggug ................. ................. 5'-R(*CP*AP*CP*CP*GP*GP*AP*UP*GP*GP*UP*(BRO) UP*CP*GP*GP*UP*G)-3'; RNA (5'-R(*CP*AP*CP*CP*GP*GP*AP*UP*GP*GP*UP*(5BU)P*CP*GP*GP*UP*G)-3') 406d E 17 1.8 URS000080E2A1_32630 9917398 32630 caccggaugguncggug ................. ................. 5'-R(*CP*AP*CP*CP*GP*GP*AP*UP*GP*GP*UP*(BRO) UP*CP*GP*GP*UP*G)-3'; RNA (5'-R(*CP*AP*CP*CP*GP*GP*AP*UP*GP*GP*UP*(5BU)P*CP*GP*GP*UP*G)-3') 413d A 13 1.8 URS000080E061_32630 9927725 32630 ugagcuucggcuc ............. ............. A'-FORM RNA DOUBLE HELIX IN THE SINGLE CRYSTAL STRUCTURE OF R(UGAGCUUCGGCUC); RNA (5'-R(*UP*GP*AP*GP*CP*UP*UP*CP*GP*GP*CP*UP*C)-3') 420d A 16 1.9 URS000080DE73_32630 10052954 32630 gcagaguuaaaucugc ................ ................ CRYSTAL STRUCTURE OF A 16-MER RNA DUPLEX WITH NON-ADJACENT A(ANTI).G(SYN) MISMATCHES; RNA (5'-R(*GP*CP*AP*GP*AP*GP*UP*UP*AP*AP*AP*UP*CP*UP*GP*C)-3') 420d B 16 1.9 URS000080DE73_32630 10052954 32630 gcagaguuaaaucugc ................ ................ CRYSTAL STRUCTURE OF A 16-MER RNA DUPLEX WITH NON-ADJACENT A(ANTI).G(SYN) MISMATCHES; RNA (5'-R(*GP*CP*AP*GP*AP*GP*UP*UP*AP*AP*AP*UP*CP*UP*GP*C)-3') 422d A 12 2.6 URS000080E0A5_32630 14684886 32630 gaucacuucggu ............ ............ 5'-R(*GP*AP*UP*CP*AP*CP*UP*UP*CP*GP*GP*U)-3'; 5'-R(*GP*AP*UP*CP*AP*CP*UP*UP*CP*GP*GP*U)-3' 422d B 12 2.6 URS000080E0A5_32630 14684886 32630 gaucacuucggu ............ ............ 5'-R(*GP*AP*UP*CP*AP*CP*UP*UP*CP*GP*GP*U)-3'; 5'-R(*GP*AP*UP*CP*AP*CP*UP*UP*CP*GP*GP*U)-3' 429d A 13 2.7 URS000080DF09_32630 10074945 32630 cggaccgagccag ............. ............. CRYSTAL STRUCTURE OF A LEADZYME; METAL BINDING AND IMPLICATIONS FOR CATALYSIS; RNA (5'-R(*CP*GP*GP*AP*CP*CP*GP*AP*GP*CP*CP*AP*G)-3') 429d B 11 2.7 URS000080E1D3_32630 10074945 32630 gcugggagucc ........... ........... CRYSTAL STRUCTURE OF A LEADZYME; METAL BINDING AND IMPLICATIONS FOR CATALYSIS; RNA (5'-R(*GP*CP*UP*GP*GP*GP*AP*GP*UP*CP*C)-3') 429d C 13 2.7 URS000080DF09_32630 10074945 32630 cggaccgagccag ............. ............. CRYSTAL STRUCTURE OF A LEADZYME; METAL BINDING AND IMPLICATIONS FOR CATALYSIS; RNA (5'-R(*CP*GP*GP*AP*CP*CP*GP*AP*GP*CP*CP*AP*G)-3') 429d D 11 2.7 URS000080E1D3_32630 10074945 32630 gcugggagucc ........... ........... CRYSTAL STRUCTURE OF A LEADZYME; METAL BINDING AND IMPLICATIONS FOR CATALYSIS; RNA (5'-R(*GP*CP*UP*GP*GP*GP*AP*GP*UP*CP*C)-3') 433d A 14 2.1 URS000080DEC4_32630 10076005 32630 gguauugcgguacc .............. .............. CRYSTAL STRUCTURE OF A 14 BASE PAIR RNA DUPLEX WITH NONSYMMETRICAL TANDEM G.U WOBBLE BASE PAIRS; 5'-R(*GP*GP*UP*AP*UP*UP*GP*CP*GP*GP*UP*AP*CP*C)-3' 433d B 14 2.1 URS000080DEC4_32630 10076005 32630 gguauugcgguacc .............. .............. CRYSTAL STRUCTURE OF A 14 BASE PAIR RNA DUPLEX WITH NONSYMMETRICAL TANDEM G.U WOBBLE BASE PAIRS; 5'-R(*GP*GP*UP*AP*UP*UP*GP*CP*GP*GP*UP*AP*CP*C)-3' 462d A 23 2.3 URS000080E21C_32630 10574792 32630 cuugcugaggugcacacagcaag ....................... ....................... CRYSTAL STRUCTURE OF THE HIV-1 GENOMIC RNA DIMERIZATION INITIATION SITE; RNA (5'-R(*CP*UP*UP*GP*CP*UP*GP*AP*GP*GP*UP*GP*CP*AP*CP*AP*CP*AP*GP*CP*AP*AP*G) -3') 462d B 23 2.3 URS000080E21C_32630 10574792 32630 cuugcugaggugcacacagcaag ....................... ....................... CRYSTAL STRUCTURE OF THE HIV-1 GENOMIC RNA DIMERIZATION INITIATION SITE; RNA (5'-R(*CP*UP*UP*GP*CP*UP*GP*AP*GP*GP*UP*GP*CP*AP*CP*AP*CP*AP*GP*CP*AP*AP*G) -3') 486d A 74 7.5 RF00005 URS000080E131_562 10497122 0030533 0006412 562 uccgugauaguuuaanggncagaaunccaganugaanaunuggagaunggggnucaauuccccgucgcggagcc <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>....<<<<<.......>>>>>>>>>>>>... (((((((..(((..........))).((((.........))))....(((((.......))))))))))))... X-RAY CRYSTAL STRUCTURES OF 70S RIBOSOME FUNCTIONAL COMPLEXES; P-SITE TRNA OF 70S RIBOSOME 486d C 72 7.5 RF00005 URS000080DE99_4932 10497122 0030533 4932 gcggauuuancucagnngggagagcncccgcuugucncgugggagnucnugugnucgnuccacagaauucgc <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>> (((((((..((((.....[..)))).(((((.......))))).....(((((..]....)))))))))))) X-RAY CRYSTAL STRUCTURES OF 70S RIBOSOME FUNCTIONAL COMPLEXES; A-SITE TRNA OF 70S RIBOSOME 488d A 16 3.1 URS000080DF69_32630 10882069 32630 guggucugaugaggcc ................ ................ CATALYTIC RNA ENZYME-PRODUCT COMPLEX; RNA RIBOZYME STRAND 488d B 20 3.1 URS000080E0B4_32630 10882069 32630 ggccgaaacucguaagagun ........<<<....>>>.. ........(((....))).. CATALYTIC RNA ENZYME-PRODUCT COMPLEX; FIRST RNA FRAGMENT OF CLEAVED SUBSTRATE 488d D 25 3.1 URS000080E0D1_32630 10882069 32630 ggccgaaacucguaagagucaccac ........<<<....>>>....... .......((((....))))...... CATALYTIC RNA ENZYME-PRODUCT COMPLEX; UNCLEAVED RNA SUBSTRATE 4a2x L 14 4.0 URS000080E082_32630 22000019 32630 gggagaacaacgcg .............. .............. Structure of duck RIG-I C-terminal domain (CTD) with 14-mer dSRNA; 5'-R(*GP*GP*GP*AP*GP*AP*AP*CP*AP*AP*CP*GP*CP*GP)-3' 4a2x M 14 4.0 URS000080DF40_32630 22000019 32630 cgcguuguucuccc .............. .............. Structure of duck RIG-I C-terminal domain (CTD) with 14-mer dSRNA; 5'-R(*CP*GP*CP*GP*UP*UP*GP*UP*UP*CP*UP*CP*CP*CP)-3' 4a2x N 14 4.0 URS000080E082_32630 22000019 32630 gggagaacaacgcg .............. .............. Structure of duck RIG-I C-terminal domain (CTD) with 14-mer dSRNA; 5'-R(*GP*GP*GP*AP*GP*AP*AP*CP*AP*AP*CP*GP*CP*GP)-3' 4a2x O 14 4.0 URS000080DF40_32630 22000019 32630 cgcguuguucuccc .............. .............. Structure of duck RIG-I C-terminal domain (CTD) with 14-mer dSRNA; 5'-R(*CP*GP*CP*GP*UP*UP*GP*UP*UP*CP*UP*CP*CP*CP)-3' 4a36 R 19 3.7 URS000080E2E4_32630 22000019 32630 gcaugcgaccucuguuuga ................... ................... Structure of duck RIG-I helicase domain bound to 19-mer dsRNA and ATP transition state analogue; 5'-R(*GP*CP*AP*UP*GP*CP*GP*AP*CP*CP*UP*CP*UP*GP *UP*UP*UP*GP*A)-3' 4a36 S 19 3.7 URS000080E143_32630 22000019 32630 ucaaacagaggucgcaugc ................... ................... Structure of duck RIG-I helicase domain bound to 19-mer dsRNA and ATP transition state analogue; 5'-R(*UP*CP*AP*AP*AP*CP*AP*GP*AP*GP*GP*UP*CP*GP *CP*AP*UP*GP*C)-3' 4a36 T 18 3.7 URS000080E2E4_32630 22000019 32630 gcaugcgaccucuguuug .................. .................. Structure of duck RIG-I helicase domain bound to 19-mer dsRNA and ATP transition state analogue; 5'-R(*GP*CP*AP*UP*GP*CP*GP*AP*CP*CP*UP*CP*UP*GP *UP*UP*UP*GP*A)-3' 4a36 U 18 3.7 URS000080E143_32630 22000019 32630 caaacagaggucgcaugc .................. .................. Structure of duck RIG-I helicase domain bound to 19-mer dsRNA and ATP transition state analogue; 5'-R(*UP*CP*AP*AP*AP*CP*AP*GP*AP*GP*GP*UP*CP*GP *CP*AP*UP*GP*C)-3' 4ang S 13 3.5 URS000080E2BE_12024 23519411 12024 uaaggaguaccua <<.<<....>>>> ((.(......))) Small RNA phage PRR1 in complex with an RNA operator fragment; 5'-R(*CP*CP*AP*UP*AP*AP*GP*GP*AP*GP*CP*UP*AP*CP *CP*UP*AP*UP*GP*GP)-3' 4aob A 94 2.95 RF00162 URS000080DF6B_119072 22539525 0010468 119072 ggcuuaucaagagagggcaagagacuggcuugaugacccccggcaaccaaaaauggugccaauuccugcagaggaaacguugaaagaugagcca <<<<<<<<......<<<...<<<...((>>>......>>>.<<<<.<<<....>>>>>>>....))..<<<.<....>.>>>...>>>>>>>>. ((((((((....(.(((...(((.[.[[)))......))))(((..(((....))).)))...(]].](((.(....).)))..))))))))). SAM-I riboswitch containing the T. solenopsae Kt-23 in complex with S- adenosyl methionine; SAM-I RIBOSWITCH 4aqy A 1510 3.5 RF00177,RF01959,RF01960 URS000080E226_274 22699498 0003735 0005840 274 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucuucu ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<<.....>>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<.......<<<<.<<..<<<<<<<....>>>>>>>...<<<<....>>>>..>>.>>>>..<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.....)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((.(.((..(((((((....)))))))...((........))...))).)))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...(...((.......))).....)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........ Structure of ribosome-apramycin complexes; 16S RIBOSOMAL RNA 4aqy Z 15 3.5 URS000080E1F5_274 22699498 274 gggauugaaaauccc .<...........>. ............... Structure of ribosome-apramycin complexes; 5'-R(*GP*GP*GP*AP*UP*UP*GP*AP*AP*AP*AP*UP*CP*CP*C)-3' 4b3m A 1512 2.9 RF00177,RF01959,RF01960 URS000080DFED_300852 24473108 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggauccuuucu ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<<.....>>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<.<<..<<<<<<<....>>>>>>>...<<<<....>>>>...>>>>>>>.<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<<..>>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>........... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.....)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((...((...(((((......)))))....((((....))))...))..)))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...(...(((.....)))).....)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....((((.(((.((((....))))).)))...))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.......... Crystal structure of the 30S ribosome in complex with compound 1; 16S RIBOSOMAL RNA 4b3m Z 16 2.9 URS000080E2E2_300852 24473108 300852 ggggauugaaaauccc .<<<<<.....>>>>> .((((.......)))) Crystal structure of the 30S ribosome in complex with compound 1; 5'-R(*GP*GP*GP*AP*UP*UP*GP*AP*AP*AP*AP*UP*CP*CP*CP)-3' 4b3r A 1512 3.0 RF00177,RF01959,RF01960 URS000080DFED_300852 24473108 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggauccuuucu ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<<.....>>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<.<<..<<<<<<<....>>>>>>>...<<<<....>>>>...>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>........... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.....)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((..((..(((((((....)))))))...((((....))))...)).))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...(...(((.....)))).....)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.......... Crystal structure of the 30S ribosome in complex with compound 30; 16S RIBOSOMAL RNA 4b3r Z 15 3.0 URS000080E2E2_300852 24473108 300852 gggauugaaaauccc <<<<<.....>>>>> ((((.......)))) Crystal structure of the 30S ribosome in complex with compound 30; 5'-R(*GP*GP*GP*AP*UP*UP*GP*AP*AP*AP*AP*UP*CP*CP*CP-3' 4b3s A 1510 3.15 RF00177,RF01959,RF01960 URS000080DFED_300852 24473108 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucuucu ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<<.....>>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<.<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<<....>>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>..>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.....)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((.((..(((((((....)))))))...((((....))))...)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...(...(((.....)))).....)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((...(..((((....))))..).....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((.((((...(.((((....(((....))).)))).)..)))).))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........ Crystal structure of the 30S ribosome in complex with compound 37; 16S RIBOSOMAL RNA 4b3s Z 15 3.15 URS000080E2E2_300852 24473108 300852 gggauugaaaauccc .<<<<.....>>>>. (.((.......)).) Crystal structure of the 30S ribosome in complex with compound 37; 5'-R(*GP*GP*GP*AP*UP*UP*GP*AP*AP*AP*AP*UP*CP*CP*CP)-3' 4b3t A 1512 3.0 RF00177,RF01959,RF01960 URS000080DFED_300852 24473108 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggauccuuucu ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<<.....>>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<.......<<<<<<<..<<<<<<<....>>>>>>>...<<<<....>>>>..>>>>>>>..<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<<..>>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>........... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.....)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((...((..(((((((....)))))))...((((....))))...))..)))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...(...(((.....)))).....)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((...((((((((((((...(.((((....(((....))).)))).)..))))))))))))...))).))))..).))...)..)..(((((((((....)))))))))}.......... Crystal structure of the 30S ribosome in complex with compound 39; 16S RIBOSOMAL RNA 4b3t Z 15 3.0 URS000080E2E2_300852 24473108 300852 gggauugaaaauccc <<<<<.....>>>>> ((((.......)))) Crystal structure of the 30S ribosome in complex with compound 39; 5'-R(*GP*GP*GP*AP*UP*UP*GP*AP*AP*AP*AP*UP*CP*CP*CP)-3' 4b5r A 94 2.95 RF00162 URS000080DFE5_119072 23325110 0010468 119072 ggcuuaucaagagagggggagcgacuggcgcgaagaaccccggcaaccagaaauggugccaauuccugcagcggaaacguugaaagaugagccg <<<<<<<<......<<<...<<<...((>>>......>>>.<<<<.<<<....>>>>>>>....))..<<<<<....>>>>>...>>>>>>>>. ((((((((....(.(((...(((.[.[[)))......))))(((..(((....))).)))...(]].](((((....)))))..))))))))). SAM-I riboswitch bearing the H. marismortui K-t-7; SAM-I RIBOSWITCH 4bpb C 10 2.584 URS000080DF81_9606 22000018 9606 gcgcgcgcgc .......... .......... STRUCTURAL INSIGHTS INTO RNA RECOGNITION BY RIG-I; 5'-R(*GP*CP*GP*CP*GP*CP*GP*CP*GP*CP)-3' 4bpb D 10 2.584 URS000080DF81_9606 22000018 9606 gcgcgcgcgc .......... .......... STRUCTURAL INSIGHTS INTO RNA RECOGNITION BY RIG-I; 5'-R(*GP*CP*GP*CP*GP*CP*GP*CP*GP*CP)-3' 4bts AA 1717 3.703 RF01960,RF01959,RF00177 URS000021954A_5911 23851459 0003735 0005840 5911 aaccugguugauccugccaguuacauaugcuugucuuaaauauuaacccaugcaugugccaguucaguauugaacagcgaaacugcgaauggcucauuaaaacaguuauaguuuauuugauaauuaaagauuacauggauaaccgagcuaauuguugggcuaauacaugcuuaaaauuccguguccugcgaccggaacguauuuauuagauauuagaccaaucgcagcaaugugauugagaugaaucaaaguaacugaucggaucgagguuuaccucgauaaaucaucuaaguuucugcccuaucagcucucgaugguaguguauuggacuaccauggcagucacggguaacggagaauuaggguucgauuccggagaaggagccugagaaacggcuacuacaacuacgguucggcagcagggaagaaaauuggccaauccuaauucagggagccagugacaagaaauagcaagcugggaaacuuacguuucuacggcauugaaaugagaacaguguaaaucucuuagcgaggaacaauuggagggcaagucauggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuucuguucagguucauuucgauucgucgugugaaacuggacauacguuugcguaaacauuuuacugugaaaaaauuagaguguuccaggcagguuuuagcccgaauacauuagcauggaauaauggaauaggacuaaguccauuuuauugguucuuggauuugguaaugauuaauagggacaguugggggcauuaguauuuaauagucagaggugaaauucuuggauuuauuaaggacuaacuaaugcgaaagcauuugccaaagauguuuucauuaaucaagaacgaaaguuaggggaucaaagacgaucagauaccgucguagucuuaacuauaaacuauaccgacucgggaucggcuggaauaaauguccagucggcaccguaugagaaaucaaagucuuuggguucugggggaaguaugguacgcaagucugaaacuuaaaggaauugacggaacagcacaccagaaguggaaccugcggcuuaauuugacucaacacggggaaacucacgagcgcaagacagagaagggauugacagauugagagcucuuucuugauucuuugggugguggugcauggccguucuuaguugguggagugauuugucugguuaauuccguuaacgaacgagaccuuaaccugcuaacuagucugcuuguaaauaacagguuguacuucuuagagggacuauugugcaauaagccaauggaaguuuaaggcaauaacaggucugugaugccccuagacgugcucggccgcacgcgcguuacaaugacuggcgcaaaaaguauuuccuguccugggaagguacggguaaucuuauuaauaccagucguguuagggauaguucuuuggaauuguggaucuugaacgaggaauuucuaguaagugcaagucaucagcuugcguugauuaugucccugccguuuguacacaccgcccgucgcuuguaguaacgaauggucuggugaaccuucuggacugcgacagcaauguugcggaaaaauaaguaaacccuaccauuuggaacaacaagaagucguaacaagguaucuguaggugaaccugcagauggaucauua ...<<<<<.{.[[[[>>>>><.<.<<<<<<...<<<<.........<<<.<<<..<<....<<...<<........>>...>>.>>......<<..<.....<<<..<<..<<....<<<<..............<<.....<<.<<<.....>>>.>>......>>.........<<<<<.<<<....>>>>>>>>.<...<<<<<........((((((..<<<....>>>......<......>..>>>>>.....>...<<<<<<....>>>>>>...>>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<<<<<<....>>>>...>>>>>>>.<<.<<<..........>>>.>>..<<<....>>>.....>>>>>>.........<<<....<<<.....>>>..>>>......>>>>.....<<<<<<<.<.<<<....>>>>...>>>>.>>>..........<<.........>>.............<<<<<((........<<<.....<<..))>>.......>>>..>>>>>..>>>>>>.>.>.........<<<[[.....<.<<...<<<.<<....<<<<<<<.<<<<<..<<<<..>>>>.>>>>>.>>>>>>>...<<<<<..>>>>>...<<<<<<<<.......<<...<.......>..<<<....>>>....>>......>>>>>..>>>.........<<<<<<<<<<.....))))))..>>>>>>>>>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>...<<<<<<<<...<...<<<<.........>>>>...>>>>>>>>>.........<<<.<<.<<<..<<<<<<<<<.......>>>>>>>>>..>>>...<<..]]>>...>>.....>>>.>>>.<<<......<<.<<....>>>>....>>>..]]]].}<<<<<.<<<.<<<.<<.<<<<<<..<<<.<<<<<.......<<........>>..........<<<<<<<....<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<<<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<..<<<<<<.....>>>>>>...>>>..>>>>.>>....<<<<.<<.....>>>>>>.......>>>>>....>>>.>>>...>.>>>>>>>.....>>>>>>>....>.>>>>.>>>.....<<<<<<.......<<.....<<<<<<<<....>>>.>>>>>....>>........>>>>>>...........<<.<<<..........>>>.>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>.>>>>>>.>>....<..<<.<.<<<<<.<<..<<<<<<<<..<<<..<<.<..<...<<<<<<<<....>>>>>>>>...>..>.>>..>>>..>>>>>>>>..>>.>>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))(.(.((((((...((((..((.....(((.(((..((....((...((........))...)){))......(((.......(((..((..((....((((..........{...((.....((.(((.....))).))......)).........(((((.(((....)))))))).(.(.(((((........[[[[[[(.(((....))).)....(......)..))))).)...).(}((((((....)))))))..))))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).((((....))).)...)))))).).....(.(((...((((.}...))).))))).)...)))).....(((((((.(((((....)))))..)))).)))....(.(.(.((.........)))..)......)..((((([[....(.(.(((.....((..]])).......))))))))))..)))))).).)..{......((({{...(.(.((...(((.((....(((((((.(((((..(((....))).))))).)))))))...((((....))))...((((((((.......((..((.......)).(((....)))....))......)))))..))).........((((((((((.....]]]]]]..)))))))))).....))...(((.(((.((...((((..((...((((((....((........)).......))))))...)).......((....))...))))..)).)))..))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..(((((((((.......)))))))))..)))...((..}}))...))...}.))))))).(((......((.((....))))....)))...]]].](((((.(((.(((.((..(((((..(((.((((((......((........))..........(((((.(....((.(((....(..((.(((........))).))....)))).))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..((((.((((((.....)))))).).)))..)))).))..(.((((.((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...((((((.......((.....((((((((....))).)))))....))........))))))......(....((.(((..........))).))....)..)..))))).....((((((((.......))))))))......))...))).)))))).))..(.(..((.(.((((..((..((((((((..(((..((.(..(...((((.(((....))).))))...)..).))..)))..))))))))..))..))))..).))...)..)..(((((((((....)))))))))>........ THE CRYSTAL STRUCTURE OF THE EUKARYOTIC 40S RIBOSOMAL SUBUNIT IN COMPLEX WITH EIF1 AND EIF1A; 18S ribosomal RNA 4bts BA 1717 3.703 RF01960,RF01959,RF00177 URS000021954A_5911 23851459 0003735 0005840 5911 aaccugguugauccugccaguuacauaugcuugucuuaaauauuaacccaugcaugugccaguucaguauugaacagcgaaacugcgaauggcucauuaaaacaguuauaguuuauuugauaauuaaagauuacauggauaaccgagcuaauuguugggcuaauacaugcuuaaaauuccguguccugcgaccggaacguauuuauuagauauuagaccaaucgcagcaaugugauugagaugaaucaaaguaacugaucggaucgagguuuaccucgauaaaucaucuaaguuucugcccuaucagcucucgaugguaguguauuggacuaccauggcagucacggguaacggagaauuaggguucgauuccggagaaggagccugagaaacggcuacuacaacuacgguucggcagcagggaagaaaauuggccaauccuaauucagggagccagugacaagaaauagcaagcugggaaacuuacguuucuacggcauugaaaugagaacaguguaaaucucuuagcgaggaacaauuggagggcaagucauggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuucuguucagguucauuucgauucgucgugugaaacuggacauacguuugcguaaacauuuuacugugaaaaaauuagaguguuccaggcagguuuuagcccgaauacauuagcauggaauaauggaauaggacuaaguccauuuuauugguucuuggauuugguaaugauuaauagggacaguugggggcauuaguauuuaauagucagaggugaaauucuuggauuuauuaaggacuaacuaaugcgaaagcauuugccaaagauguuuucauuaaucaagaacgaaaguuaggggaucaaagacgaucagauaccgucguagucuuaacuauaaacuauaccgacucgggaucggcuggaauaaauguccagucggcaccguaugagaaaucaaagucuuuggguucugggggaaguaugguacgcaagucugaaacuuaaaggaauugacggaacagcacaccagaaguggaaccugcggcuuaauuugacucaacacggggaaacucacgagcgcaagacagagaagggauugacagauugagagcucuuucuugauucuuugggugguggugcauggccguucuuaguugguggagugauuugucugguuaauuccguuaacgaacgagaccuuaaccugcuaacuagucugcuuguaaauaacagguuguacuucuuagagggacuauugugcaauaagccaauggaaguuuaaggcaauaacaggucugugaugccccuagacgugcucggccgcacgcgcguuacaaugacuggcgcaaaaaguauuuccuguccugggaagguacggguaaucuuauuaauaccagucguguuagggauaguucuuuggaauuguggaucuugaacgaggaauuucuaguaagugcaagucaucagcuugcguugauuaugucccugccguuuguacacaccgcccgucgcuuguaguaacgaauggucuggugaaccuucuggacugcgacagcaauguugcggaaaaauaaguaaacccuaccauuuggaacaacaagaagucguaacaagguaucuguaggugaaccugcagauggaucauua ...<<<<<.{.((((>>>>><.<.<<<<<<...<<<<.........<<<.<<<..<<....<<...<<........>>...>>.>>......<<..<.....<<<..<<..<<....<<<<..............<<.....<<.<<<.....>>>.>>......>>.........<<<<<.<<<....>>>>>>>>.<...<<<<<.........((((...<<......>>......<......>..>>>>>.....>...<<<<<<....>>>>>>...>>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<<<<<<....>>>>...>>>>>>>.<<.<<<..........>>>.>>..<<<....>>>.....>>>>>>.........<<<....<<<.....>>>..>>>......>>>>.....<<<<<<<.<<<.<....>>>>...>>>>.>>>..........<<.........>>.............<<<<<((........<<<.....<<..))>>.......>>>..>>>>>..>>>>>>.>.>.........<<<[[.....<.<<...<<<.<<....<<<<<<<.<<<<<..<<<<..>>>>.>>>>>.>>>>>>>...<<<<<..>>>>>...<<<<<<<<.......<<...<.......>..<<<....>>>....>>......>>>>>..>>>.........<<<<<<<<<<......))))...>>>>>>>>>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>...<<<<<<<<...<...<<<<.........>>>>...>>>>>>>>>.........<<<.<<.<<<..<<<<<<<<<.......>>>>>>>>>..>>>...<<..]]>>...>>.....>>>.>>>.<<<......<<.<<....>>>>....>>>..)))).}<<<<<.<<<.<<<.<<.<<<<<<..<<<.<<<<<.......<<........>>..........<<<<<<<....<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<<<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<..<<<<<<.....>>>>>>...>>>..>>>>.>>....<<<<.<<.....>>>>>>.......>>>>>....>>>.>>>...>.>>>>>>>.....>>>>>>>....>.>>>>.>>>.....<<<<<<.......<<.....<<<<<<<<....>>>.>>>>>....>>........>>>>>>...........<<.<<<..........>>>.>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>.>>>>>>.>>....<..<<.<.<<<<<.<<..<<<<<<<<..<<<..<<.<..<...<<<<<<<<....>>>>>>>>...>..>.>>..>>>..>>>>>>>>..>>.>>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))(.(.((((((...((((..((.....(((.(((..((....((...((........))...))[))......(((.......(((..((..((....((((..........[...((.....((.(((.....))).))......)).........(((((.(((....)))))))).(.(.(((((.........{{{{.(.(((....))).)....(......)..))))).)...).(]((((((....)))))))..))))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).((((....))).)...)))))).).....(.(((...((((.]...))).))))).)...)))).....(((((((.(((((....)))))..)))).)))....(.(.(.((.........)))..)......)..((((([[....(.(.(((.....((..]])).......))))))))))..)))))).).)..[......((([[...(.(.((...(((.((....(((((((.(((((..(((....))).))))).)))))))...((((....))))...((((((((.......((..((.......)).(((....)))....))......)))))..))).........((((((((((.....}.}}}...)))))))))).....))...(((.(((.((...((((..((...((((((....((........)).......))))))...)).......((....))...))))..)).)))..))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(((((((((.......)))))))))..)))...((..]]))...))...].))))))).(((......((.((....))))....)))...]]].](((((.(((.(((.((..(((((..(((.((((((......((........))..........(((((.(....((.(((....(..((.(((........))).))....)))).))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..((((.((((((.....)))))).).)))..)))).))..(.((((.((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...((((((.......((.....((((((((....))).)))))....))........))))))......(....((.(((..........))).))....)..)..))))).....((((((((.......))))))))......))...))).)))))).))..(.(..((.(.((((..((..((((((((..(((..((.(..(...((((.(((....))).))))...)..).))..)))..))))))))..))..))))..).))...)..)..(((((((((....)))))))))}........ THE CRYSTAL STRUCTURE OF THE EUKARYOTIC 40S RIBOSOMAL SUBUNIT IN COMPLEX WITH EIF1 AND EIF1A; 18S ribosomal RNA 4by9 A 72 NA URS000080E041_2261 24121435 2261 gcgagcaaugaugagugaugggcgaacugagcucgaaagagcaaugaugagugaugggcgaacugagcucgc <<<<<<....<...................<<<<....>>>>.....................>..>>>>>> ((((((......(.............(...((((....))))......).............)...)))))) The structure of the Box CD enzyme reveals regulation of rRNA methylation; SSR26 4by9 B 72 NA URS000080E041_2261 24121435 2261 gcgagcaaugaugagugaugggcgaacugagcucgaaagagcaaugaugagugaugggcgaacugagcucgc <<<<<<....<...................<<<<....>>>>.....................>..>>>>>> ((((((......(.............(...((((....))))......).............)...)))))) The structure of the Box CD enzyme reveals regulation of rRNA methylation; SSR26 4by9 W 11 NA URS000080E0A0_2261 24121435 2261 ucgcccaucac ........... ........... The structure of the Box CD enzyme reveals regulation of rRNA methylation; 5'-R(*UP*CP*GP*CP*CP*CP*AP*UP*CP*AP*CP)-3' 4by9 X 11 NA URS000080E0A0_2261 24121435 2261 ucgcccaucac ........... ........... The structure of the Box CD enzyme reveals regulation of rRNA methylation; 5'-R(*UP*CP*GP*CP*CP*CP*AP*UP*CP*AP*CP)-3' 4by9 Y 11 NA URS000080E0A0_2261 24121435 2261 ucgcccaucac ........... ........... The structure of the Box CD enzyme reveals regulation of rRNA methylation; 5'-R(*UP*CP*GP*CP*CP*CP*AP*UP*CP*AP*CP)-3' 4by9 Z 11 NA URS000080E0A0_2261 24121435 2261 ucgcccaucac ........... ........... The structure of the Box CD enzyme reveals regulation of rRNA methylation; 5'-R(*UP*CP*GP*CP*CP*CP*AP*UP*CP*AP*CP)-3' 4c40 A 19 2.2 URS000080E16F_2238 24149842 2238 ggcgaagaaccggggagcc ................... ................... The molecular recognition of kink turn structure by the L7Ae class of proteins; 5'-(*GP*GP*CP*GP*AP*AP*GP*AP*AP*CP*CP*GP*GP*GP *GP*AP*GP*CP*C)-3' 4cs1 A 19 2.0 URS000080E16F_2238 25351101 2238 ggcgaagaaccggggagcc ................... ................... Crystal structure of a simple duplex kink turn, HmKt-7 with 2 Mg bound.; 5'-(*GP*GP*CP*GP*AP*AP*GP*AP*AP*CP*CP*GP*GP*GP *GP*AP*GP*CP*CP)-3' 4csu A 115 5.5 RF00001 URS0000366A67_83333 24844575 0003735 0005840 83333 gcugcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggc .<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.....<.<<<<<<<<...>>>>>>>>...>...>>...>>>>.>>.. .((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))).)).. Cryo-EM structures of the 50S ribosome subunit bound with ObgE; 5S RRNA 4csu B 2903 5.5 RF02540,RF02541 URS000080E25C_83333 24844575 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu 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((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((...(((((((((.....(((...(((.((((...((..(((.....)))...))...)))).)))..)).).....)))))).)))...))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.......(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((..((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....((((..(((..(((((((((((....{{{...))))))((..((((...(((.((((((((.((.....))))))))))...)))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((((.(......[....(((...........(((..(((....)))..)))................].)))..).)))).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.((((((...))))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Cryo-EM structures of the 50S ribosome subunit bound with ObgE; 23S RRNA 4cxg 1 135 8.7 RF01960 URS000080E168_9986 24995983 0003735 0005840 9986 cgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggucggcccacggcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaa ....<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<.<<<<<<<<<<<<.....>>>>>>>>>>>>...>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...... .(..((.(..((((.((..(.((((.(((.(((..(.((..(...((.((.(((((.(((.((.....)).))).)))))...)).))...)..)).)..))).))).)))))..)).))))...).))...).. Regulation of the mammalian elongation cycle by 40S subunit rolling: a eukaryotic-specific ribosome rearrangement; 18S RRNA - H44 4cxg Y 76 8.7 RF00005 URS000080DDA3_9986 24995983 0030533 0006412 9986 gcggauuuancucagnngggagagcnccggunuccanaaccggagnucnugugnucgnuccacagaauucgcacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).(((((.......))))).....(((((..]....)))))))))))).... Regulation of the mammalian elongation cycle by 40S subunit rolling: a eukaryotic-specific ribosome rearrangement; TRANSFER RNA 4cxg a 48 8.7 RF01960,RF02542 URS000080DE49_9986 24995983 0003735 0005840 9986 acauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccgg .<.<<....>>.>..........................<<<...>>> .(.((....)).)..........................((.....)) Regulation of the mammalian elongation cycle by 40S subunit rolling: a eukaryotic-specific ribosome rearrangement; 18S RRNA - H5-H14 4cxg b 17 8.7 URS000080DF66_9986 24995983 9986 cugugguaauucuagag <<.<<.......>>.>> ((.(((.....))).)) Regulation of the mammalian elongation cycle by 40S subunit rolling: a eukaryotic-specific ribosome rearrangement; 18S RRNA - H8 4cxg x 28 8.7 24995983 562 uuuuuuuuuuuuuuuuuuuuuuuuuuuu ............................ ............................ Regulation of the mammalian elongation cycle by 40S subunit rolling: a eukaryotic-specific ribosome rearrangement; MESSENGER RNA 4cxh 1 135 8.9 RF01960 URS000080E168_9986 24995983 0003735 0005840 9986 cgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggucggcccacggcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaa ....<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<.<<<<<<<<<<<<.....>>>>>>>>>>>>...>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...... .(..((.(..((((.((..(.((((.(((.(((..(.((..(...((.((.(((((.(((.((.....)).))).)))))...)).))...)..)).)..))).))).)))))..)).))))...).))...).. Regulation of the mammalian elongation cycle by 40S subunit rolling: a eukaryotic-specific ribosome rearrangement; 18S RRNA - H44 4cxh Y 76 8.9 RF00005 URS000080DDA3_9986 24995983 0030533 0006412 9986 gcggauuuancucagnngggagagcnccggunuccanaaccggagnucnugugnucgnuccacagaauucgcacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).(((((.......))))).....(((((..]....)))))))))))).... Regulation of the mammalian elongation cycle by 40S subunit rolling: a eukaryotic-specific ribosome rearrangement; TRANSFER RNA 4cxh a 48 8.9 RF01960,RF02542 URS000080DE49_9986 24995983 0003735 0005840 9986 acauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccgg .<.<<....>>.>..........................<<<...>>> .(.((....)).)..........................((.....)) Regulation of the mammalian elongation cycle by 40S subunit rolling: a eukaryotic-specific ribosome rearrangement; 18S RRNA - H5-H14 4cxh b 17 8.9 URS000080DF66_9986 24995983 9986 cugugguaauucuagag <<.<<.......>>.>> ((.(((.....))).)) Regulation of the mammalian elongation cycle by 40S subunit rolling: a eukaryotic-specific ribosome rearrangement; 18S RRNA - H8 4cxh x 28 8.9 24995983 562 uuuuuuuuuuuuuuuuuuuuuuuuuuuu ............................ ............................ Regulation of the mammalian elongation cycle by 40S subunit rolling: a eukaryotic-specific ribosome rearrangement; MESSENGER RNA 4d5y 2 3616 9.0 RF02543,RF02540 URS000043B91E_9986 25601755 0003735 0005840 9986 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggccggcgcgcgcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcggcccggcggaucuuucccgcgcgggggaccgucccccggaccggcgaccggccgccgccgggcgcauuuccaggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucgggggcccccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcgcucuccccccucccggccccccggggggggccgggccaccccucccacggcgcgaccgcucucccaccccuccucccgggucggggggcggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccgggggagguucucucggggccacgcgcgcgucccccgggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgaggggcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcuccaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcacugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggaggccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcugggugcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacaugagagguguagaauaagugggaggcccgggccgccggugaaauaccacuacucugaucguuuuuucacugacccggugaggcgggggggcgagcccgaggggcucucgcuucuggcgccaagcgcccgcccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucgccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcgaacgauacggcagcgccgcggagccucgguuggccucggauagccggucccccgccuguccccgccggcgccgcgcgccgggaccgggguccggugcggagugcccuucguccugggaaacggggcgcggccggaaaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuu .........................<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..[[[..<.......<..<<....<.....>....>>..>.......>..<<<<<<<<.......<<.<<<.<<<.......<<<<.....<<<<......>>>>.....((......<<<.....))>>>.....>>>>>>>>>>>>....>>>>>>>>.......<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>................<.......>....................................<<<<<<<<..<<<......<<<<<.<<<<.........<<<<<<<......<<<<..<<<<.<<<.<<<<.<<<<.<<<<<<<<>>>>>>>>..>>>>.>>>>.>>>.>>>>.>>>>>>>>>>>.......>>>>.>>>>>..<<<<<.<<..<<<<<<<.<..<<<.<.........<<.<<<.....<<.<<<<<<<..>>>>>>>...>>....>>>.>>...........>.>>>.....>>>>>>>>..............<<.<<<..<<<<.....<<....<<<<<<<<<..>>>>>>>>>...<.<<<<<.<<<<<<<<<<<<<<.<........<<<.<.<<..>>..>>>>...<<<<<<.<<<......>>>.>>>>>>.>.>.>>>>>>>>>>>.>>....>>>>>.>.........>>......<<<.<<<<<<<..>>>>>>>>>>.>>>>.>>>..>>...>>..>>>>>....>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<<....>>>>>>>>..<<<<<..<<<<..<<<...........>>>..>>>>..>>>>>.<<<<<<<<<.<<<........>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<......<<<....>>>..<<.<<<<<<.<<.<<<<<<<<....<<<....<<<....<<<..<<<<.<.........>.>>>>>>>....>>>..>.>>....>>>>>>....<<<<<<<<.........>>>>>>>>....>>>>..>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<......<..........<<<.<<<<<<<<<........<<...>>....>>>>>>>>>>>>..........))).>....>>>>>..>>>...>>>>>>><<<<<<.<...>.>>>>>>....>>>>>>...<<<<<<<..<<......<<<<.<<<<....>>>>>>>>....>>.>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<<<<<...>>>>>>>>>>>......>>....>>...<<<<<........>>>>>))<<<<..<<.......<<<<<<<<....>>>>>>>>..<<<....>>>......<<<<<<<...<<<<<<<<<<<<<<<<<<<<<<<..{{{..>>>>>>.....<<<<..<<<.<<<<.....<<<.....>>>.....>>>>>>>...>>>>......<<<<<<<.......>>>>>>>>>>>.>.>>>>>>>>>>>>.........>>>>>>>................>>..>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<...............<<<<<...............>>>>><<.<<<<<<<<<<......>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>>.<<<<.........>>>>.........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{.[[[[..<<<<<.<<<<<<<<<.<<<<<..<<<.<.<<<<..........<<<<<..<<<<..>>>>............>>>>>.>>>>.>..>>>..>>>>>...<<<<<......<<<.....<<<.<.....>.>>>................<<<<<<<......>>>>>>>..>>>...>>>>>....>>>>>>>>>..>>>>>....<<.....>>...<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>>.<<<....>>>.>>)))]......((((((..(((..>>>>>>.)))))))))..........]]]]...}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]].....<<<<<<....<<<....<<<<<.................>>>>>..<<<<....<<<<....<<.<<<<<<.}}}..>>>>..>>.>>...>>>>...>>>>.<<<<...<<<<<...........>>>>>...>>>>..>>>....>>>>>>.....<<<<<<<.<<..<<<.<...<<<.........<<<<.<<<....<<.....<<<<<<..>>>.>>>..>>.....>>>.>>>>........>>>...<<<..<<<.....<<<<.<<<<<<<......>>>>>>>>>>>....>>>..>>>.............>.>>>..>>>>>>>>>.<<<<.....................<.<<<<<<<.<<.....<<<<....<<<<<......>>>>>...>>>>....>>....>>>>.>>>.>..>>.>>. .........................(((((......(......).......)))).).........((....))...((((......((.....)).....))))...(((.............((...............)).............((((((((..........(((.((........((((.....(((........))).....[.(...).(((......]))).....)))).)))))......)))))))).......((((((..........))))))......(.((..[[[..[)).)...)))..................................((....))............(..((.(....).))............).....................(((((((...(((.......((((.(((........(.(((((((......(((((.((((.((..((((.(((..(..((((()))))..)...))).))))..)).)))))))))))))))).)......))).))))....((((((..(.((.(((.(.(((..((......(.((.((((....(..(((((((())))))))....)...)))).)).)........))..)))...).))).)).)..............(((((..(.(.....(((..((.((((((((..)))))))).)).(.(.((((..(.((((((((((.((......(((.(..((()))..).)))..((.(((.((........)).))).)))).).))))))))).)...)...))).).).........)))......((.(((((((())))))))))...).).))).)).....).))))).....)))....)))))))..((((........))))((((((....(((((((((((((..(((...((((........)))).....)))...((....))...((((((((....))))))))...((((...(((..(((...........)))..)))...))))..((((..(((.((((......)))))))..)).))....)))))))))))))..((.(...((((((.....(((((((((..((.....(((((((....)))))))......))...(((..((.((.......{)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((.(..((.(((((((.....(((.....((..(.(((...(.....(.....).....).))).)..))...)).).....))))).....(((((((.(......)))))))).....))))...).)))..))..((((.(((((.....))))).))))....(((......)))...((((.((...((([[[.....(.(((((......(..........(((.((((((((((........(...)....)))))))))))))..........]]].)....)))))).)))...)).))))(((((.........)))))....)))))).(.(((((((..((.......(((.((((....))))))).....)).)))))))..).....)))))).(......(.....((((((.......)))))).(((.....((((..((..(((((((...((.....)).))))))....[[(((.((...(.....(((....)))..........((.(((..(.((...)).)..))))).......)....))...(((((........)))))]]((((..((..(....(((.(((......))).))).((((....)))...(...(((((....(((.(((.((((((((((.(((.........))).)......(...((((.((((.....(((.....))).....))))))))....).......(((((((.......))))))))))).).)))).))).)))(...).....)))))...))..........).))..)))).))).))).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((....)))))..)))))).))(...).......(((((((((...((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(...((.....((((....)))).....)).)))))..))))).((.(.........).).)........((..........((((.........))))..)..)....)))....)).))))))).)..))).)))))))..))))).....)..[..(((((......].)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((...((((.(((...........(((((..((((()))))............)))))..))).)).))...)))))....((((.......((.....((((((...))))))................(((((((......)))))))...))...))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((...((((((.......)))))).....((]..[[[))....)))))))...(((..((((.......))))..))).((......)).))]]].......((((((..(((..]..]]].)))))))))....).....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).).......(((((.(..(((..(...(.(((......))).).....).(((.(.....).))).....)))....)...))).))....(((((((....))).))))..}.))..))).)))))......(.(((....(((....(((((......(....).....)))))..((((....((((....(..(.(((((....)))))...)..)...))))...)))).((((...((((.............))))...))))..)))....))).)......((((((..((..((.(....(((.........((((.((((..((.(....((((((()))).))).).))...)))).))))........)))....((...(((....((((.(((((((......)))))))))))...)))...))...............).))..)).)))))).((((....(.......)........(.(((((((..(.....((((.(..(.((........)).)..)))))....).....)))).))).)..)).)). Cryo-EM structures of ribosomal 80S complexes with termination factors and cricket paralysis virus IRES reveal the IRES in the translocated state; 28S Ribosomal RNA 4d5y 3 157 9.0 RF00002 URS000080DE76_9986 25601755 0003735 0005840 9986 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>.............>>>..)...>>>....<<<..>>><<<<<<<<<.....>>>>>>>>>..................... .........................................((((((.[[....[)))...].(.((((.....]]...........).)))..)...)))....(((..))).((((((((.....))))))))...................... Cryo-EM structures of ribosomal 80S complexes with termination factors and cricket paralysis virus IRES reveal the IRES in the translocated state; 5.8S Ribosomal RNA 4d5y 4 119 9.0 RF00001 URS000064027A_9986 25601755 0003735 0005840 9986 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcu .<<<<<<<<....<<<<<<<<.....<<.<<..............>>...>>....>>>>>>.>>.<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>.>>>>>>>>.. ((.((..(.....((((((((.....((......................))....)))))).)).((.(((.....((.((..((....)).)).))....))).))..)..)).).) Cryo-EM structures of ribosomal 80S complexes with termination factors and cricket paralysis virus IRES reveal the IRES in the translocated state; 5S Ribosomal RNA 4d61 1 1742 9.0 RF01960,RF01959,RF00177 URS000080DD44_9986 25601755 0003735 0005840 9986 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucgcuccucucccacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucagaucaaaaccaacccguagauaaccucgggccgaucgcacgccccccguggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcgcgccccuugccucucggcgcgcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggucggcccacggccucggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<..{.[[[[.>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<...<<<.....................>>>>>......<<........<<<......<<....<<<......................<....<<.<<.......>>.>>......>...........<<<...<<<<<......>>>>>...>>>.....<<<<<........((((((.....>>>>>...........<<<<..<<<......>>>.>>>>....>>>...>>....>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<<<<<<....>>>>...>>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....<<<<<<<<<.<<<....>>>..>>>>>.>>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<[[.....<.<<...<<<.<<....<<<.<<<>>>>>>.......<<<<.<..>>>>>.....<<<<<..<.......<<...<.......>..<<<.......>>>....>>......>..>>..>>>..........<<.<<<<<<<.....))))))....>>>>>>>.>>......>>....<<<<<<......<<<<..<<..<<<<<<<....<<<......>>>.......>>>>>>>..>>.......<<....>>...>>>>.....>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<....<<<<<<.<<<<......>>>>>>>>>>....>>>...<<..]]>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..]]]].}<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<........<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<...<.<<....<<...<<<<....>>>>..>>....>>.>...>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.....>.>>>>>......>>>>.>>>.....<<.<<<................<<<.<<<<....>>>>.>>>..............>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<.<<<<<<<<<<<<.....>>>>>>>>>>>>...>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>.........<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..)))).((.(((.((...(.....((.....(((.(((..(....(((.....................))).)......(((.......(((...(..(.....(((......................(....((.(((.....))).))......)...........(((...((.(((....))).))...))).....(((((.......[[..[[[.....))))).............((.(.((......)).)))......)))....))...))).(((....(((....(((((((.........))))))))))......)))....((.((((....))))....)).))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.....))).))))).)......).....((.((((((.(((....)))..))))).).))......(...(...........)...).........((((([[......((((.....((..]])).......)))).)))))..)).))).))...{......(.({{.....(.((....((.(......((.((()))))........((((.(())))))........(((.(.......((..(.........).(((.......)))....))......).)))................(.(.((((......]]]...]]...)))).).)........)...(((.(((..(...((((..((..((((((.(...((........))......).))))))..)).......((....))...))))..)..)))..))..)))....)).)....((((((....(...((.(.........).))...).))))))......<...(((.((..((..(.((((((.((..........)))))))).)..))....((..}}))...))...}.))).).)..((......((((....))))....))....]]].](.(((.(..(((...((..(((((..(((.((((((.......(........)...........(((((.(....((((.........((..((........))..)).......))))...((.(((..((.((((((....(((.(((.(....).)....((......))....)).)))....(((...(.(.(((...((.(....(((...(((....)))..)))....).))...)))).).....((((.......))))........)))....))).))).....))))))).....).)))))...)).)))).))).(...((.(((........(.......(((.(.((....)).).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....((.((..(.......)..)).))......))....).)).))))..)..(.(..((.(..((((.((..(.((((.(((.(((..(.((..(...((.((.((((((.((.((.....)).)).))))))...)).))...)..)).)..))).))).)))))..)).))))...).))...)..)..(((((((((....)))))))))>........ Cryo-EM structures of ribosomal 80S complexes with termination factors and cricket paralysis virus IRES reveal the IRES in the translocated state; 18S RRNA 4d61 j 201 9.0 RF00458 URS000080E194_12136 25601755 0043022 12136 aaaaaugugaucuugcuuguaaauacaauuuugagagguuaauaaauuacaaguagugcuauuuuuguauuuagguuagcuauuuagcuuuacguuccaggaugccuaguggcagccccacaauauccaggaagcccucucugcgguuauucagauuagguagucgaaaaaccuaagaaauuuaccuuaaggcuuccucga <<.............<<<<<<<.<........(((((......>..>>>>>>>...........>>......<<<<..<<<....>>>......((((..(..>>>>.<<<<.....>>>>.....)..))))...)))))....[[..(((.(((.<<<<.))))))..]]...........>>>>.............. ((.............(((((((..........[[[.[.........)))))))...........))......[[[....((....)).......((((.((.(.]]]..(((.....)))....).)).))))...].]]]....[...[[[.[[..((((..]]]]]...]...........)))).............. Cryo-EM structures of ribosomal 80S complexes with termination factors and cricket paralysis virus IRES reveal the IRES in the translocated state; CRICKET PARALYSIS VIRUS IRES RNA 4d67 2 3616 9.0 RF02543,RF02540 URS000043B91E_9986 25601755 0003735 0005840 9986 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggccggcgcgcgcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcggcccggcggaucuuucccgcgcgggggaccgucccccggaccggcgaccggccgccgccgggcgcauuuccaggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucgggggcccccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcgcucuccccccucccggccccccggggggggccgggccaccccucccacggcgcgaccgcucucccaccccuccucccgggucggggggcggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccgggggagguucucucggggccacgcgcgcgucccccgggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgaggggcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcuccaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcacugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggaggccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcugggugcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacaugagagguguagaauaagugggaggcccgggccgccggugaaauaccacuacucugaucguuuuuucacugacccggugaggcgggggggcgagcccgaggggcucucgcuucuggcgccaagcgcccgcccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucgccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcgaacgauacggcagcgccgcggagccucgguuggccucggauagccggucccccgccuguccccgccggcgccgcgcgccgggaccgggguccggugcggagugcccuucguccugggaaacggggcgcggccggaaaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuu .........................<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..[[[..<.......<..<<....<.....>....>>..>.......>..<<<<<<<<.......<<.<<<.<<<.......<<<<.....<<<<......>>>>.....((......<<<.....))>>>.....>>>>>>>>>>>>....>>>>>>>>.......<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>................<.......>....................................<<<<<<<<..<<<......<<<<<.<<<<.........<<<<<<<......<<<<..<<<<.<<<.<<<<.<<<<.<<<<<<<<>>>>>>>>..>>>>.>>>>.>>>.>>>>.>>>>>>>>>>>.......>>>>.>>>>>..<<<<<.<<..<<<<<<<.<..<<<.<.........<<.<<<.....<<.<<<<<<<..>>>>>>>...>>....>>>.>>...........>.>>>.....>>>>>>>>..............<<.<<<..<<<<.....<<....<<<<<<<<<..>>>>>>>>>...<.<<<<<.<<<<<<<<<<<<<<.<........<<<.<.<<..>>..>>>>...<<<<<<.<<<......>>>.>>>>>>.>.>.>>>>>>>>>>>.>>....>>>>>.>.........>>......<<<.<<<<<<<..>>>>>>>>>>.>>>>.>>>..>>...>>..>>>>>....>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<<....>>>>>>>>..<<<<<..<<<<..<<<...........>>>..>>>>..>>>>>.<<<<<<<<<.<<<........>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<......<<<....>>>..<<.<<<<<<.<<.<<<<<<<<....<<<....<<<....<<<..<<<<.<.........>.>>>>>>>....>>>..>.>>....>>>>>>....<<<<<<<<.........>>>>>>>>....>>>>..>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<......<..........<<<.<<<<<<<<<........<<...>>....>>>>>>>>>>>>..........))).>....>>>>>..>>>...>>>>>>><<<<<<.<...>.>>>>>>....>>>>>>...<<<<<<<..<<......<<<<.<<<<....>>>>>>>>....>>.>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<<<<<...>>>>>>>>>>>......>>....>>...<<<<<........>>>>>))<<<<..<<.......<<<<<<<<....>>>>>>>>..<<<....>>>......<<<<<<<...<<<<<<<<<<<<<<<<<<<<<<<..{{{..>>>>>>.....<<<<..<<<.<<<<.....<<<.....>>>.....>>>>>>>...>>>>......<<<<<<<.......>>>>>>>>>>>.>.>>>>>>>>>>>>.........>>>>>>>................>>..>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<...............<<<<<...............>>>>><<.<<<<<<<<<<......>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>>.<<<<.........>>>>.........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{.[[[[..<<<<<.<<<<<<<<<.<<<<<..<<<.<.<<<<..........<<<<<..<<<<..>>>>............>>>>>.>>>>.>..>>>..>>>>>...<<<<<......<<<.....<<<.<.....>.>>>................<<<<<<<......>>>>>>>..>>>...>>>>>....>>>>>>>>>..>>>>>....<<.....>>...<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>>.<<<....>>>.>>)))]......((((((..(((..>>>>>>.)))))))))..........]]]]...}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]].....<<<<<<....<<<....<<<<<.................>>>>>..<<<<....<<<<....<<.<<<<<<.}}}..>>>>..>>.>>...>>>>...>>>>.<<<<...<<<<<...........>>>>>...>>>>..>>>....>>>>>>.....<<<<<<<.<<..<<<.<...<<<.........<<<<.<<<....<<.....<<<<<<..>>>.>>>..>>.....>>>.>>>>........>>>...<<<..<<<.....<<<<.<<<<<<<......>>>>>>>>>>>....>>>..>>>.............>.>>>..>>>>>>>>>.<<<<.....................<.<<<<<<<.<<.....<<<<....<<<<<......>>>>>...>>>>....>>....>>>>.>>>.>..>>.>>. .........................(((((......(......).......)))).).........((....))...((((......((.....)).....))))...(((.............((...............)).............((((((((..........(((.((........((((.....(((........))).....[.(...).(((......]))).....)))).)))))......)))))))).......((((((..........))))))......(.((..[[[..[)).)...)))..................................((....))............(..((.(....).))............).....................(((((((...(((.......((((.(((........(.(((((((......(((((.((((.((..((((.(((..(..((((()))))..)...))).))))..)).)))))))))))))))).)......))).))))....((((((..(.((.(((.(.(((..((......(.((.((((....(..(((((((())))))))....)...)))).)).)........))..)))...).))).)).)..............(((((..(.(.....(((..((.((((((((..)))))))).)).(.(.((((..(.((((((((((.((......(((.(..((()))..).)))..((.(((.((........)).))).)))).).))))))))).)...)...))).).).........)))......((.(((((((())))))))))...).).))).)).....).))))).....)))....)))))))..((((........))))((((((....(((((((((((((..(((...((((........)))).....)))...((....))...((((((((....))))))))...((((...(((..(((...........)))..)))...))))..((((..(((.((((......)))))))..)).))....)))))))))))))..((.(...((((((.....(((((((((..((.....(((((((....)))))))......))...(((..((.((.......{)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((.(..((.(((((((.....(((.....((..(.(((...(.....(.....).....).))).)..))...)).).....))))).....(((((((.(......)))))))).....))))...).)))..))..((((.(((((.....))))).))))....(((......)))...((((.((...((([[[.....(.(((((......(..........(((.((((((((((........(...)....)))))))))))))..........]]].)....)))))).)))...)).))))(((((.........)))))....)))))).(.(((((((..((.......(((.((((....))))))).....)).)))))))..).....)))))).(......(.....((((((.......)))))).(((.....((((..((..(((((((...((.....)).))))))....[[(((.((...(.....(((....)))..........((.(((..(.((...)).)..))))).......)....))...(((((........)))))]]((((..((..(....(((.(((......))).))).((((....)))...(...(((((....(((.(((.((((((((((.(((.........))).)......(...((((.((((.....(((.....))).....))))))))....).......(((((((.......))))))))))).).)))).))).)))(...).....)))))...))..........).))..)))).))).))).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((....)))))..)))))).))(...).......(((((((((...((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(...((.....((((....)))).....)).)))))..))))).((.(.........).).)........((..........((((.........))))..)..)....)))....)).))))))).)..))).)))))))..))))).....)..[..(((((......].)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((...((((.(((...........(((((..((((()))))............)))))..))).)).))...)))))....((((.......((.....((((((...))))))................(((((((......)))))))...))...))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((...((((((.......)))))).....((]..[[[))....)))))))...(((..((((.......))))..))).((......)).))]]].......((((((..(((..]..]]].)))))))))....).....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).).......(((((.(..(((..(...(.(((......))).).....).(((.(.....).))).....)))....)...))).))....(((((((....))).))))..}.))..))).)))))......(.(((....(((....(((((......(....).....)))))..((((....((((....(..(.(((((....)))))...)..)...))))...)))).((((...((((.............))))...))))..)))....))).)......((((((..((..((.(....(((.........((((.((((..((.(....((((((()))).))).).))...)))).))))........)))....((...(((....((((.(((((((......)))))))))))...)))...))...............).))..)).)))))).((((....(.......)........(.(((((((..(.....((((.(..(.((........)).)..)))))....).....)))).))).)..)).)). Cryo-EM structures of ribosomal 80S complexes with termination factors and cricket paralysis virus IRES reveal the IRES in the translocated state; 28S RRNA 4d67 3 157 9.0 RF00002 URS000080DE76_9986 25601755 0003735 0005840 9986 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>.............>>>..)...>>>....<<<..>>><<<<<<<<<.....>>>>>>>>>..................... .........................................((((((.[[....[)))...].(.((((.....]]...........).)))..)...)))....(((..))).((((((((.....))))))))...................... Cryo-EM structures of ribosomal 80S complexes with termination factors and cricket paralysis virus IRES reveal the IRES in the translocated state; 5.8S RRNA 4d67 4 119 9.0 RF00001 URS00000F9D45_9986 25601755 0003735 0005840 9986 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcu .<<<<<<<<....<<<<<<<<.....<<.<<..............>>...>>....>>>>>>.>>.<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>.>>>>>>>>.. ((.((..(.....((((((((.....((......................))....)))))).)).((.(((.....((.((..((....)).)).))....))).))..)..)).).) Cryo-EM structures of ribosomal 80S complexes with termination factors and cricket paralysis virus IRES reveal the IRES in the translocated state; 5S RRNA 4db2 E 14 3.157 URS000080DF70_32630 22940866 32630 gggcgggcccgccc .............. .............. Mss116p DEAD-box helicase domain 2 bound to an RNA duplex; 5'-R(*GP*GP*GP*CP*GP*GP*GP*CP*CP*CP*GP*CP*CP*C)-3' 4db2 F 14 3.157 URS000080DF70_32630 22940866 32630 gggcgggcccgccc .............. .............. Mss116p DEAD-box helicase domain 2 bound to an RNA duplex; 5'-R(*GP*GP*GP*CP*GP*GP*GP*CP*CP*CP*GP*CP*CP*C)-3' 4db2 G 13 3.157 URS000080DF70_32630 22940866 32630 gggcgggcccgcc ............. ............. Mss116p DEAD-box helicase domain 2 bound to an RNA duplex; 5'-R(*GP*GP*GP*CP*GP*GP*GP*CP*CP*CP*GP*CP*CP*C)-3' 4db2 H 14 3.157 URS000080DF70_32630 22940866 32630 gggcgggcccgccc .............. .............. Mss116p DEAD-box helicase domain 2 bound to an RNA duplex; 5'-R(*GP*GP*GP*CP*GP*GP*GP*CP*CP*CP*GP*CP*CP*C)-3' 4db2 I 14 3.157 URS000080DF70_32630 22940866 32630 gggcgggcccgccc .............. .............. Mss116p DEAD-box helicase domain 2 bound to an RNA duplex; 5'-R(*GP*GP*GP*CP*GP*GP*GP*CP*CP*CP*GP*CP*CP*C)-3' 4db2 J 14 3.157 URS000080DF70_32630 22940866 32630 gggcgggcccgccc .............. .............. Mss116p DEAD-box helicase domain 2 bound to an RNA duplex; 5'-R(*GP*GP*GP*CP*GP*GP*GP*CP*CP*CP*GP*CP*CP*C)-3' 4dr4 A 1512 3.969 RF00177,RF01959,RF01960 URS000080DE21_300852 23322043 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauccuuucu ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<.......>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<...<<<<<<<<.<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<<....>>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>..>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>...........>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>........... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.((...(((..((.((((((((.(.....).)))))))).)))))......(((......((((((((..((...(((((((.(((((....((((.(.....))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))....))))).).....(.(((...(.(((....)))..))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((.(..((((((((((......((........))..........(((((((..(...((.(((....(((((((....))))))).....((....))......))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..((...(((.....))).))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((...((.((((....))))).).....))).....)))))))......(....(((((((........)))))))....)..)..).))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((.((((((...(.((((....(((....))).)))).)..)))))).))))))..))).))))..).))...)..)..(((((((((....)))))))))}.......... Crystal structure of the Thermus thermophilus (HB8) 30S ribosomal subunit with codon, cognate transfer RNA anticodon stem-loop and multiple copies of paromomycin molecules bound; 16S rRNA 4dr4 W 15 3.969 URS000080E1F5_300852 23322043 300852 gggauugaaaauccc .<<<<.....>>>>. .(((.......))). Crystal structure of the Thermus thermophilus (HB8) 30S ribosomal subunit with codon, cognate transfer RNA anticodon stem-loop and multiple copies of paromomycin molecules bound; 5'-R(*GP*GP*GP*AP*UP*UP*GP*AP*AP*AP*AP*UP*CP*CP*C)-3' 4dr5 A 1512 3.45 RF00177,RF01959,RF01960 URS000080DE21_300852 23322043 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauccuuucu ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<.......>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<.<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<<....>>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>..>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>........... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((.(.....).)))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((.(..(((((((....))))))).....((....)).....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(....(((.....)))..)...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.......... Crystal structure of the Thermus thermophilus (HB8) 30S ribosomal subunit with codon, crystallographically disordered cognate transfer RNA anticodon stem-loop and streptomycin bound; 16S rRNA 4dr5 W 15 3.45 URS000080E1F5_300852 23322043 300852 gggauugaaaauccc .<<<<.....>>>>. .(((.......))). Crystal structure of the Thermus thermophilus (HB8) 30S ribosomal subunit with codon, crystallographically disordered cognate transfer RNA anticodon stem-loop and streptomycin bound; 5'-R(*GP*GP*GP*AP*UP*UP*GP*AP*AP*AP*AP*UP*CP*CP*C)-3' 4dr6 A 1514 3.3 RF00177,RF01959,RF01960 URS000080DE21_300852 23322043 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauccacuccuu ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<<.....>>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>...<<<<....>>>>...>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............. ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((.(.....).)))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((....(((((((....))))))).....((....).).....))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((.......(((.....)))......)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}............ Crystal structure of the Thermus thermophilus (HB8) 30S ribosomal subunit with codon, near-cognate transfer RNA anticodon stem-loop mismatched at the first codon position and streptomycin bound; 16S rRNA 4dr6 a 11 3.3 URS000080E115_300852 23322043 300852 cuugagguggu ........... ........... Crystal structure of the Thermus thermophilus (HB8) 30S ribosomal subunit with codon, near-cognate transfer RNA anticodon stem-loop mismatched at the first codon position and streptomycin bound; 5'-R(P*CP*UP*UP*GP*AP*GP*GP*(PSU)P*GP*GP*U)-3' 4dr7 A 1513 3.75 RF00177,RF01959,RF01960 URS000080DE21_300852 23322043 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauccacuccu ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<<<<<<<<<.....>>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<.......<<<<<<<..<<<<<<<....>>>>>>>...<<<<....>>>>..>>>>>>>..<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>............ ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((.(((.........))).)))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((......((((((.(..(((((((....)))))))......(....)......)))))))..((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((.......(((.....)))......)))))))..(...((((....))))......)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((...((((((((((((...(.((((....(((....))).)))).)..))))))))))))...))).))))..).))...)..)..(((((((((....)))))))))}........... Crystal structure of the Thermus thermophilus (HB8) 30S ribosomal subunit with codon, crystallographically disordered near-cognate transfer RNA anticodon stem-loop mismatched at the second codon position, and streptomycin bound; 16S rRNA 4dr7 W 11 3.75 URS000080E121_300852 23322043 300852 gccuggaaagu ........... ........... Crystal structure of the Thermus thermophilus (HB8) 30S ribosomal subunit with codon, crystallographically disordered near-cognate transfer RNA anticodon stem-loop mismatched at the second codon position, and streptomycin bound; 5'-R(*GP*CP*CP*UP*GP*GP*AP*AP*AP*GP*(PSU))-3' 4e48 A 20 2.5 URS000080E27B_32630 22731704 32630 gcugcugcugcugcugcugc .................... .................... Structure of 20mer double-helical RNA composed of CUG/CUG-repeats; 5'-R(P*GP*CP*UP*GP*CP*UP*GP*CP*UP*GP*CP*UP*GP*CP*UP*GP*CP*UP*GP*C)-3' 4e48 B 20 2.5 URS000080E27B_32630 22731704 32630 gcugcugcugcugcugcugc .................... .................... Structure of 20mer double-helical RNA composed of CUG/CUG-repeats; 5'-R(P*GP*CP*UP*GP*CP*UP*GP*CP*UP*GP*CP*UP*GP*CP*UP*GP*CP*UP*GP*C)-3' 4e48 D 20 2.5 URS000080E27B_32630 22731704 32630 gcugcugcugcugcugcugc .................... .................... Structure of 20mer double-helical RNA composed of CUG/CUG-repeats; 5'-R(P*GP*CP*UP*GP*CP*UP*GP*CP*UP*GP*CP*UP*GP*CP*UP*GP*CP*UP*GP*C)-3' 4e5c A 19 1.7 URS000080DF49_32630 22731704 32630 ggcggcggcggcugcugcc ................... ................... Crystal Structure of 19mer double-helical RNA containing CUG/CGG-repeats; 5'-R(P*GP*GP*CP*GP*GP*CP*GP*GP*CP*GP*GP*CP*UP*GP*CP*UP*GP*CP*C)-3' 4e5c B 19 1.7 URS000080DF49_32630 22731704 32630 ggcggcggcggcugcugcc ................... ................... Crystal Structure of 19mer double-helical RNA containing CUG/CGG-repeats; 5'-R(P*GP*GP*CP*GP*GP*CP*GP*GP*CP*GP*GP*CP*UP*GP*CP*UP*GP*CP*C)-3' 4e8k A 388 3.03 RF02001,RF01998 URS000080DE44_182710 23101623 0000373 182710 gugcccggcaugggugcagucuauagggugagagucccgaacugugaaggcagaaguaacaguuagccuaacgcaaggguguccguggcgacauggaaucugaaggaagcggacggcaaaccuucggucugaggaacacgaacuucauaugaggcuagguaucaauggaugaguuugcauaacaaaacaaaguccuuucugccaaaguugguacagaguaaaugaagcagauugaugaagggaaagacugcauucuuacccggggaggucuggaaacagaagucagcagaagucauaguacccuguucgcaggggaaggacggaacaaguauggcguucgcgccuaagcuugaaccgccguauaccgaacgguacguacgguggugug ...<<<<<...<<<<<<<<<<<...<<<.......>>>..(((((...<<<<<<<...)))))..<<<...<<<..<<<<.<<<<<<....>>>>>>>>>>.......>>>...>>>...(((((([[[[[...........[[[[[......[[[....((((((<<<<..<<<<........>>>>...>>>>.>>>>>>>...))))))....]]]...]]]]]]]]]]...))))))...>>>>>>>>>>>....>>>>>....<<<<....>>>>...........<<<......<<<<<....>>>>>....>>>....<<<<<..<<<<....>>>>...>>>>>.<<<<<<<<<<<<<....>>>..>>>>>>>>>>... [<.((((({..(((((((((((...(((.......)))..(((((....[[[[[[...)))))..(((...(((..((((.((((((....))))))))))...>}..)))...)))...(((((((((((.(.....)...(((((.....[(((....(.((((((((..((((.]......))))...)))).]]]]]]....)))).)....)))...))))))))))...))))))...)))))))))))...])))))(...((((....))))...).......(((.(....(((........)))...))))....(((((..((((....))))...))))).(((((((((((((....)))..))))))))))... Structure of Oceanobacillus iheyensis group II intron in the presence of K+, Ca2+ and a non-hydrolyzed oligonucleotide substrate; Group IIC intron 4e8t A 388 3.34 RF02001,RF01998 URS000080DE44_182710 23101623 0000373 182710 gugcccggcaugggugcagucuauagggugagagucccgaacugugaaggcagaaguaacaguuagccuaacgcaaggguguccguggcgacauggaaucugaaggaagcggacggcaaaccuucggucugaggaacacgaacuucauaugaggcuagguaucaauggaugaguuugcauaacaaaacaaaguccuuucugccaaaguugguacagaguaaaugaagcagauugaugaagggaaagacugcauucuuacccggggaggucuggaaacagaagucagcagaagucauaguacccuguucgcaggggaaggacggaacaaguauggcguucgcgccuaagcuugaaccgccguauaccgaacgguacguacgguggugug ...<<<<<...<<<<<<<<<<<...<<<.......>>>..(((((...<<<<<<<...)))))..<<<...<<<..<<<<.<<<<<<....>>>>>>>>>>.......>>>...>>>...(((((([[[[[...........[[[[[......[[[....((((((<<<<..<<<<........>>>>...>>>>.>>>>>>>...))))))....]]]...]]]]]]]]]]...))))))...>>>>>>>>>>>....>>>>>....<<<<....>>>>...........<<<......<<<<<....>>>>>....>>>....<<<<<..<<<<....>>>>...>>>>>.<<<<<<<<<<<<<....>>>..>>>>>>>>>>... [<.((((({..(((((((((((...(((.......)))..(((((...[[[[[[[...)))))..(((...(((..((((.((((((....))))))))))...>}..)))...)))...(((((((((((.(.....)...(((((.....[(((....(.((((((((..((((.]......))))...)))).]]]]]]]...)))).)....)))...))))))))))...))))))...)))))))))))...])))))(...((((....))))...).......(((.(....(((........)))...))))....(((((..((((....))))...))))).(((((((((((((....)))..))))))))))... Structure of Oceanobacillus iheyensis group II intron in the presence of K+, Ca2+ and an oligonucleotide fragment substrate (low energy dataset); Group IIC intron 4erd C 22 2.589 URS000080DDC3_5911 22705372 5911 ggucgacaucuucggauggacc ...................... ...................... Crystal structure of the C-terminal domain of Tetrahymena telomerase protein p65 in complex with stem IV of telomerase RNA; 5'-R(P*GP*GP*UP*CP*GP*AP*CP*AP*UP*CP*UP*UP*CP*GP*GP*AP*UP*GP*GP*AP*CP*C)-3' 4erd D 22 2.589 URS000080DDC3_5911 22705372 5911 ggucgacaucuucggauggacc ...................... ...................... Crystal structure of the C-terminal domain of Tetrahymena telomerase protein p65 in complex with stem IV of telomerase RNA; 5'-R(P*GP*GP*UP*CP*GP*AP*CP*AP*UP*CP*UP*UP*CP*GP*GP*AP*UP*GP*GP*AP*CP*C)-3' 4eya a 12 3.2 URS000080DF91_32630 22692544 32630 ggcuccuuggca ............ ............ Crystal Structure of a Plectonemic RNA Supercoil; RNA (5'-R(*GP*GP*CP*UP*CP*CP*UP*UP*GP*GP*CP*A)-3') 4eya c 12 3.2 URS000080DF91_32630 22692544 32630 ggcuccuuggca ............ ............ Crystal Structure of a Plectonemic RNA Supercoil; RNA (5'-R(*GP*GP*CP*UP*CP*CP*UP*UP*GP*GP*CP*A)-3') 4eya e 12 3.2 URS000080DF91_32630 22692544 32630 ggcuccuuggca ............ ............ Crystal Structure of a Plectonemic RNA Supercoil; RNA (5'-R(*GP*GP*CP*UP*CP*CP*UP*UP*GP*GP*CP*A)-3') 4eya g 12 3.2 URS000080DF91_32630 22692544 32630 ggcuccuuggca ............ ............ Crystal Structure of a Plectonemic RNA Supercoil; RNA (5'-R(*GP*GP*CP*UP*CP*CP*UP*UP*GP*GP*CP*A)-3') 4eya i 12 3.2 URS000080DF91_32630 22692544 32630 ggcuccuuggca ............ ............ Crystal Structure of a Plectonemic RNA Supercoil; RNA (5'-R(*GP*GP*CP*UP*CP*CP*UP*UP*GP*GP*CP*A)-3') 4eya j 12 3.2 URS000080DF91_32630 22692544 32630 ggcuccuuggca ............ ............ Crystal Structure of a Plectonemic RNA Supercoil; RNA (5'-R(*GP*GP*CP*UP*CP*CP*UP*UP*GP*GP*CP*A)-3') 4eya h 12 3.2 URS000080DF91_32630 22692544 32630 ggcuccuuggca ............ ............ Crystal Structure of a Plectonemic RNA Supercoil; RNA (5'-R(*GP*GP*CP*UP*CP*CP*UP*UP*GP*GP*CP*A)-3') 4eya f 12 3.2 URS000080DF91_32630 22692544 32630 ggcuccuuggca ............ ............ Crystal Structure of a Plectonemic RNA Supercoil; RNA (5'-R(*GP*GP*CP*UP*CP*CP*UP*UP*GP*GP*CP*A)-3') 4eya d 12 3.2 URS000080DF91_32630 22692544 32630 ggcuccuuggca ............ ............ Crystal Structure of a Plectonemic RNA Supercoil; RNA (5'-R(*GP*GP*CP*UP*CP*CP*UP*UP*GP*GP*CP*A)-3') 4eya b 12 3.2 URS000080DF91_32630 22692544 32630 ggcuccuuggca ............ ............ Crystal Structure of a Plectonemic RNA Supercoil; RNA (5'-R(*GP*GP*CP*UP*CP*CP*UP*UP*GP*GP*CP*A)-3') 4eya k 12 3.2 URS000080DF91_32630 22692544 32630 ggcuccuuggca ............ ............ Crystal Structure of a Plectonemic RNA Supercoil; RNA (5'-R(*GP*GP*CP*UP*CP*CP*UP*UP*GP*GP*CP*A)-3') 4eya m 12 3.2 URS000080DF91_32630 22692544 32630 ggcuccuuggca ............ ............ Crystal Structure of a Plectonemic RNA Supercoil; RNA (5'-R(*GP*GP*CP*UP*CP*CP*UP*UP*GP*GP*CP*A)-3') 4eya o 12 3.2 URS000080DF91_32630 22692544 32630 ggcuccuuggca ............ ............ Crystal Structure of a Plectonemic RNA Supercoil; RNA (5'-R(*GP*GP*CP*UP*CP*CP*UP*UP*GP*GP*CP*A)-3') 4eya q 12 3.2 URS000080DF91_32630 22692544 32630 ggcuccuuggca ............ ............ Crystal Structure of a Plectonemic RNA Supercoil; RNA (5'-R(*GP*GP*CP*UP*CP*CP*UP*UP*GP*GP*CP*A)-3') 4eya s 12 3.2 URS000080DF91_32630 22692544 32630 ggcuccuuggca ............ ............ Crystal Structure of a Plectonemic RNA Supercoil; RNA (5'-R(*GP*GP*CP*UP*CP*CP*UP*UP*GP*GP*CP*A)-3') 4eya t 12 3.2 URS000080DF91_32630 22692544 32630 ggcuccuuggca ............ ............ Crystal Structure of a Plectonemic RNA Supercoil; RNA (5'-R(*GP*GP*CP*UP*CP*CP*UP*UP*GP*GP*CP*A)-3') 4eya r 12 3.2 URS000080DF91_32630 22692544 32630 ggcuccuuggca ............ ............ Crystal Structure of a Plectonemic RNA Supercoil; RNA (5'-R(*GP*GP*CP*UP*CP*CP*UP*UP*GP*GP*CP*A)-3') 4eya p 12 3.2 URS000080DF91_32630 22692544 32630 ggcuccuuggca ............ ............ Crystal Structure of a Plectonemic RNA Supercoil; RNA (5'-R(*GP*GP*CP*UP*CP*CP*UP*UP*GP*GP*CP*A)-3') 4eya n 12 3.2 URS000080DF91_32630 22692544 32630 ggcuccuuggca ............ ............ Crystal Structure of a Plectonemic RNA Supercoil; RNA (5'-R(*GP*GP*CP*UP*CP*CP*UP*UP*GP*GP*CP*A)-3') 4eya l 12 3.2 URS000080DF91_32630 22692544 32630 ggcuccuuggca ............ ............ Crystal Structure of a Plectonemic RNA Supercoil; RNA (5'-R(*GP*GP*CP*UP*CP*CP*UP*UP*GP*GP*CP*A)-3') 4f8u A 22 2.0 URS000080E0C1_32630 24900542 32630 ugcgucacaccggugaagucgc ...................... ...................... Crystal structure of the bacterial ribosomal decoding site in complex with sisomicin (C2 form); RNA (5'-R(P*UP*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*C)-3') 4f8u B 21 2.0 URS000080DF2F_32630 24900542 32630 gcgucacaccggugaagucgc ..................... ..................... Crystal structure of the bacterial ribosomal decoding site in complex with sisomicin (C2 form); RNA (5'-R(P*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*C)-3') 4f8v A 21 2.8 URS000080DF2F_32630 24900542 32630 gcgucacaccggugaagucgc ..................... ..................... Crystal structure of the bacterial ribosomal decoding site in complex with sisomicin (P21212 form); RNA (5'-R(P*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*C)-3') 4f8v B 21 2.8 URS000080DF2F_32630 24900542 32630 gcgucacaccggugaagucgc ..................... ..................... Crystal structure of the bacterial ribosomal decoding site in complex with sisomicin (P21212 form); RNA (5'-R(P*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*C)-3') 4far A 390 2.86 RF02001,RF01998 URS000080E176_182710 23101623 0000373 182710 gugugcccggcaugggugcagucuauagggugagagucccgaacugugaaggcagaaguaacaguuagccuaacgcaaggguguccguggcgacauggaaucugaaggaagcggacggcaaaccuucggucugaggaacacgaacuucauaugaggcuagguaucaauggaugaguuugcauaacaaaacaaaguccuuucugccaaaguugguacagaguaaaugaagcagauugaugaagggaaagacugcauucuuacccggggaggucuggaaacagaagucagcagaagucauaguacccuguucgcaggggaaggacggaacaaguauggcguucgcgccuaagcuugaaccgccguauaccgaacgguacguacgguggugug .....<<<<<...<<<<<<<<<<<...<<<.......>>>..<<<<<...(((((((...>>>>>..<<<...<<<..<<<<.<<<<<<....>>>>>>>>>>.......>>>...>>>...<<<<<<<<<<<...........<<<<<......<<<..<<<<<<<<<<<<..<<<<........>>>>...>>>>.)))))))...>>>>>>>>..>>>...>>>>>>>>>>...>>>>>>...>>>>>>>>>>>....>>>>>....<<<<....>>>>...........<<<......<<<<<....>>>>>....>>>....<<<<<..<<<<....>>>>...>>>>>.<<<<<<<<<<<<<....>>>..>>>>>>>>>>... ..[<.((((({..(((((((((((...(((.......)))..(((((...[[[[[[[...)))))..(((...(((..((((.((((((....))))))))))...>}..)))...)))...(((((((((((.(.....)...(((((.....[(((..((((((((((((..((((.]......))))...)))).]]]]]]]...))))))))..)))...))))))))))...))))))...)))))))))))...])))))(...((((....))))...).......(((.(....(((........)))...))))....(((((..((((....))))...))))).(((((((((((((....)))..))))))))))... Structure of Oceanobacillus iheyensis group II intron in the presence of K+, Mg2+ and 5'-exon; Group IIC intron 4faw A 390 2.7 RF02001,RF01998 URS000080DF32_182710 23101623 0000373 182710 ugugcccggcaugggugcagucuauagggugagagucccgaacugugaaggcagaaguaacaguuagccuaacgcaaggguguccguggcgacauggaaucugaaggaagcggacggcaaaccuucggucugaggaacacgaacuucauaugaggcuagguaucaauggaugaguuugcauaacaaaacaaaguccuuucugccaaaguugguacagaguaaaugaagcagauugaugaagggaaagacugcauucuuacccggggaggucuggaaacagaagucagcagaagucauaguacccuguucgcaggggaaggacggaacaaguauggcguucgcgccuaagcuugaaccgccguauaccgaacgguacguacgguggugugg ....<<<<<...<<<<<<<<<<<...<<<.......>>>..<<<<<...(((((((...>>>>>..<<<...<<<..<<<<.<<<<<<....>>>>>>>>>>.......>>>...>>>...<<<<<<<<<<<...........<<<<<......<<<..<<<<<<<<<<<<..<<<<........>>>>...>>>>.)))))))...>>>>>>>>..>>>...>>>>>>>>>>...>>>>>>...>>>>>>>>>>>....>>>>>....<<<<....>>>>...........<<<......<<<<......>>>>....>>>....<<<<<..<<<<....>>>>...>>>>>.<<<<<<<<<<<<<....>>>..>>>>>>>>>>.... .[<.((((({..(((((((((((...(((.......)))..(((((...[[[[[[[...)))))..(((...(((..((((.((((((....))))))))))...>}..)))...)))...(((((((((((.(.....)...(((((.....[(((..(.(..(((((((..((((.]......))))...)))).]]]]]]]...)))..).)..)))...))))))))))...))))))...)))))))))))...])))))(...((((....))))...).......(((.(....(((.(....).)))...))))....(((((..((((....))))...))))).(((((((((((((....)))..)))))))))).... Structure of Oceanobacillus iheyensis group II intron in the presence of K+, Mg2+ and a hydrolyzed oligonucleotide fragment; Group IIC intron 4fsj R 14 3.5 URS000080E20F_7108 7108 uucucuuuuaucuu .............. .............. Crystal structure of the virus like particle of Flock House virus; Random cellular RNA fragments 4ftb R 15 2.7 URS000080DF7A_12287 12287 uuucucuuuuaucuu ............... ............... Crystal structure of the authentic Flock House virus particle; Flock House virus genomic RNA 4fte R 15 3.5 URS000080DF7A_7108 7108 uuucucuuuuaucuu ............... ............... Crystal structure of the D75N mutant capsid of Flock House virus; Random cellular RNAs 4fts R 15 3.2 URS000080DF7A_7108 7108 uuucucuuuuaucuu ............... ............... Crystal structure of the N363T mutant of the Flock House virus capsid; Random cellular RNAs 4g6p A 13 2.641 URS000080E09E_32630 22989273 32630 ucccnguccaccg ............. ............. Minimal Hairpin Ribozyme in the Precatalytic State with A38P Variation; Loop A Substrate strand 4g6p B 30 2.641 URS000080E2DF_32630 22989273 32630 cggugagaagggnggcagagaaacacacga .............................. .............................. Minimal Hairpin Ribozyme in the Precatalytic State with A38P Variation; Loop A and Loop B Ribozyme strand 4g6p C 19 2.641 URS000080E34C_32630 22989273 32630 ucgugguncauuaccugcc ................... ................... Minimal Hairpin Ribozyme in the Precatalytic State with A38P Variation; Loop B of the Ribozyme Strand 4g6r A 13 2.832 URS000080E09E_32630 22989273 32630 ucccnguccaccg ............. ............. Minimal Hairpin Ribozyme in the Transition State with G8I Variation; Loop A Substrate strand 4g6r B 12 2.832 URS000080E1BF_32630 22989273 32630 cggugaiaaggg ............ ............ Minimal Hairpin Ribozyme in the Transition State with G8I Variation; Loop A Ribozyme strand 4g6r C 17 2.832 URS000080DEF8_32630 22989273 32630 ggcagagaaacacacga ................. ................. Minimal Hairpin Ribozyme in the Transition State with G8I Variation; Loop B Ribozyme Strand 4g6r D 19 2.832 URS000080E34C_32630 22989273 32630 ucgugguacauuaccugcc ................... ................... Minimal Hairpin Ribozyme in the Transition State with G8I Variation; Loop B S-turn strand 4g6s A 13 2.84 URS000080E09E_32630 22989273 32630 ucccnguccaccg ............. ............. Minimal Hairpin Ribozyme in the Transition State with A38P Variation; Loop A Substrate strand 4g6s B 30 2.84 URS000080E2DF_32630 22989273 32630 cggugagaagggnggcagagaaacacacga .............................. .............................. Minimal Hairpin Ribozyme in the Transition State with A38P Variation; Loop A and Loop B Ribozyme strand 4g6s C 19 2.84 URS000080E34C_32630 22989273 32630 ucgugguncauuaccugcc ................... ................... Minimal Hairpin Ribozyme in the Transition State with A38P Variation; Loop B of the Ribozyme Strand 4gha I 12 2.5 URS000080E156_32630 23028316 32630 cuagacgucuag ............ ............ Crystal structure of Marburg virus VP35 RNA binding domain bound to 12-bp dsRNA; RNA (5'-R(*CP*UP*AP*GP*AP*CP*GP*UP*CP*UP*AP*G)-3') 4gha J 12 2.5 URS000080E156_32630 23028316 32630 cuagacgucuag ............ ............ Crystal structure of Marburg virus VP35 RNA binding domain bound to 12-bp dsRNA; RNA (5'-R(*CP*UP*AP*GP*AP*CP*GP*UP*CP*UP*AP*G)-3') 4ghl E 18 2.02 URS000080DD2A_32630 23185024 32630 agacagcauaugcugucu .................. .................. Structural Basis for Marburg virus VP35 mediate immune evasion mechanisms; short palindromic RNA AGACAGCAUAUGCUGUCU 4ghl F 18 2.02 URS000080DD2A_32630 23185024 32630 agacagcauaugcugucu .................. .................. Structural Basis for Marburg virus VP35 mediate immune evasion mechanisms; short palindromic RNA AGACAGCAUAUGCUGUCU 4gkj A 1513 3.298 RF00177,RF01959,RF01960 URS000080E11D_300852 23781103 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucacuuucu ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<.......>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<..<<...<<.<<<<....>>>>.>>...<<<<....>>>>...>>..>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.....)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((....(.....((((....))))........((....)).....)...)))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((.......(((.....)))......)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((.((((((...(.((((....(((....))).)))).)..)))))).))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Structure of the Thermus thermophilus 30S ribosomal subunit complexed with a human mitochondrial anticodon stem loop (ASL) of transfer RNA Methionine (TRNAMET) bound to an mRNA with an AUG-codon in the A-site and paromomycin.; 16S rRNA 4gkk A 1513 3.2 RF00177,RF01959,RF01960 URS000080E11D_300852 23781103 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucacuuucu ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<.......>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<.<<<...<<.<<<<....>>>>.>>...<<<<....>>>>...>>>.>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<.......<<<.....>>>......>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<..<.<<<<<<<........>>>>>>>>...>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.....)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((.......((.((((....)))).))...(.((....)).).......)))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((........((.....)).......)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((.((((((...(.((((....(((....))).)))).)..)))))).))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Structure of the Thermus thermophilus 30S ribosomal subunit complexed with a human mitochondrial anticodon stem loop (ASL) of transfer RNA Methionine (TRNAMET) bound to an mRNA with an AUA-codon in the A-site and paromomycin; 16S rRNA 4gl2 C 12 3.557 URS000080E1D7_32630 23273991 32630 auccgcggcccu ............ ............ Structural Basis for dsRNA duplex backbone recognition by MDA5; RNA (5'-R(*AP*UP*CP*CP*GP*CP*GP*GP*CP*CP*CP*U)-3') 4gl2 E 12 3.557 URS000080E1D7_32630 23273991 32630 auccgcggcccu ............ ............ Structural Basis for dsRNA duplex backbone recognition by MDA5; RNA (5'-R(*AP*UP*CP*CP*GP*CP*GP*GP*CP*CP*CP*U)-3') 4gl2 F 12 3.557 URS000080E086_32630 23273991 32630 agggccgcggau ............ ............ Structural Basis for dsRNA duplex backbone recognition by MDA5; RNA (5'-R(P*AP*GP*GP*GP*CP*CP*GP*CP*GP*GP*AP*U)-3') 4gl2 D 12 3.557 URS000080E086_32630 23273991 32630 agggccgcggau ............ ............ Structural Basis for dsRNA duplex backbone recognition by MDA5; RNA (5'-R(P*AP*GP*GP*GP*CP*CP*GP*CP*GP*GP*AP*U)-3') 4gpw A 22 3.0 URS000080E281_32630 23436717 32630 ugcgucgcgccggcgaagucgc ...................... ...................... Crystal structure of the protozoal cytoplasmic ribosomal decoding site in complex with 6'-hydroxysisomicin (P21212 form); RNA (5'-R(*UP*UP*GP*CP*GP*UP*CP*GP*CP*GP*CP*CP*GP*GP*CP*GP*AP*AP*GP*UP*CP*GP*C)-3') 4gpw B 22 3.0 URS000080E281_32630 23436717 32630 ugcgucgcgccggcgaagucgc ...................... ...................... Crystal structure of the protozoal cytoplasmic ribosomal decoding site in complex with 6'-hydroxysisomicin (P21212 form); RNA (5'-R(*UP*UP*GP*CP*GP*UP*CP*GP*CP*GP*CP*CP*GP*GP*CP*GP*AP*AP*GP*UP*CP*GP*C)-3') 4gpx A 21 2.6 URS000080E281_32630 23436717 32630 gcgucgcgccggcgaagucgc ..................... ..................... Crystal structure of the protozoal cytoplasmic ribosomal decoding site in complex with 6'-hydroxysisomicin (P212121 form); RNA (5'-R(*UP*UP*GP*CP*GP*UP*CP*GP*CP*GP*CP*CP*GP*GP*CP*GP*AP*AP*GP*UP*CP*GP*C)-3') 4gpx B 21 2.6 URS000080E281_32630 23436717 32630 gcgucgcgccggcgaagucgc ..................... ..................... Crystal structure of the protozoal cytoplasmic ribosomal decoding site in complex with 6'-hydroxysisomicin (P212121 form); RNA (5'-R(*UP*UP*GP*CP*GP*UP*CP*GP*CP*GP*CP*CP*GP*GP*CP*GP*AP*AP*GP*UP*CP*GP*C)-3') 4gpy A 22 2.8 URS000080DDE4_32630 23436717 32630 ugcgucacgccggcgaagucgc ...................... ...................... Crystal structure of the bacterial ribosomal decoding site in complex with 6'-hydroxysisomicin; RNA (5'-R(*UP*UP*GP*CP*GP*UP*CP*AP*CP*GP*CP*CP*GP*GP*CP*GP*AP*AP*GP*UP*CP*GP*C)-3') 4gpy B 22 2.8 URS000080DDE4_32630 23436717 32630 ugcgucacgccggcgaagucgc ...................... ...................... Crystal structure of the bacterial ribosomal decoding site in complex with 6'-hydroxysisomicin; RNA (5'-R(*UP*UP*GP*CP*GP*UP*CP*AP*CP*GP*CP*CP*GP*GP*CP*GP*AP*AP*GP*UP*CP*GP*C)-3') 4h5p E 14 2.15 URS000080DD9D_32630 23129612 32630 uuuuuuuuuuuuuu .............. .............. Crystal Structure of Rift Valley Fever Virus Nucleocapsid Protein Tetramer Bound to Single-stranded RNA; 28-mer poly(U) RNA 4h5p F 14 2.15 URS000080DD9D_32630 23129612 32630 uuuuuuuuuuuuuu .............. .............. Crystal Structure of Rift Valley Fever Virus Nucleocapsid Protein Tetramer Bound to Single-stranded RNA; 28-mer poly(U) RNA 4ig8 B 18 2.7 URS000080E0DC_32630 23319625 32630 ggcuuuugaccuuuaugc .................. .................. Structural basis for cytosolic double-stranded RNA surveillance by human OAS1; RNA (5'-R(*GP*GP*CP*UP*UP*UP*UP*GP*AP*CP*CP*UP*UP*UP*AP*UP*GP*C)-3') 4ig8 C 18 2.7 URS000080DF0C_32630 23319625 32630 gcauaaaggucaaaagcc .................. .................. Structural basis for cytosolic double-stranded RNA surveillance by human OAS1; RNA (5'-R(*GP*CP*AP*UP*AP*AP*AP*GP*GP*UP*CP*AP*AP*AP*AP*GP*CP*C)-3') 4io9 X 2686 3.2 RF02540,RF02541 URS000080DEF1_1299 23414806 0003735 0005840 1299 ggucaagauaguaaggguccacgguggaugcccuggcgcuggagccgaugaaggacgcgauuaccugcgaaaagccccgacgagcuggagauacgcuuugacucggggauguccgaauggggaaacccaccucguaagagguauccgcaaggaugggaacucagggaacugaaacaucucaguaccugaaggagaagaaagagaauucgauuccguuaguagcggcgagcgaacccggaucagcccaaucaagccgaaguggcuggaaagcuacaccucagaaggugagaguccuguaggcgaacgagaggucguuguucgugaaacgaugacugaauccgcgcggaccaccgcgcaaggcuaaauacucccagugaccgauagcgcauaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaagagaaccugaaaccguggacuuacaagcagucauggcaccuuaugcguguuauggcgugccuauugaagcaugagccggcgacuuagaccugacgugcgagcuuaaguugaaaaacggaggcggagcgaaagcgaguccgaauagggcggcauuaguacgucgggcuagacucgaaaccaggugagcuaagcaugaccagguugaaacccccgugacagggggcggaggaccgaaccggugccugcugaaacagucucggaugaguuguguuuaggagugaaaagcuaaccgaaccuggagauagcuaguucuccccgaaauguauugagguacagccucggauguugaccauguccuguagagcacucacaaggcuaaaaccuuaugaaacuccgaaggggcacgcguuuaguccgggagugaggcugcgagagcuaacuuccguagccgagagggaaacaacccagaccaucagcuaaggucccuaaaugaucgcucagugguuaaggaugugucgucgcauagacagccaggagguuggcuuagaagcagccacccuucaaagagugcguaauagcucacuggucgagugacgaugcgccgaaaaugaucggggcucaagugaucuaccgaagcuauggauucaacucgcgaagcgaguugucugguaggggagcguucaguccgcggagaagccauaccggaaggagugguggagccgacugaagugcggaugccggcaugaguaacgauaaaagaagugagaaucuucuucgccguaaggacaaggguuccuggggaagggucguccgcccagggaaagucgggaccuaaggugaggccgaacggcgcagccgauggacagcaggucaagauuccugcaccgaucauguggagugauggagggacgcauuacgcuauccaaugccaagcuauggcuaugcugguugguacgcucaagggcgaucgggucagaaaaucuaccggucacaugccucagacguaucgggagcuuccucggaagcgaaguuggaaacgcgacggugccaagaaaagcuucuaaacguugaaacaugauugcccguaccgcaaaccgacacagguguccgagugucaaugcacuaaggcgcgcgagagaacccucguuaaggaacuuugcaaucucaccccguaacuucggaagaagggguccccacgcuucgcguggggcgcagugaauaggcccaggcgacuguuuaccaaaaucacagcacucugccaacacgaacaguggacguauagggugugacgccugcccggugccggaaggucaaguggagcggugcaagcugcgaaaugaagccccggugaacggcuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaggcguaacgaucugggcgcugucucaacgagggacucggugaaauugaauuggcuguaaagaugcggccuacccguagcaggacgaaaagaccccguggagcuuuacuauagucuggcauugggauucggguuucuagaaacuuggauuucuaaccugaaaaaucacuuucggggaccgugcuuggcggguaguuugacuggggcggucgccucccaaaauguaacggaggcgcccaaaggucaccucaagacgguuggaaaucgucuguagagcgcaaagguagaagguggcuugacugcgagacugacacgucgagcagggaggaaacucgggcuuagugaaccggugguaccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagaguccauaucggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgcuacgggcgcaggagaauugaggggaguugcuccuaguacgagaggaccggagugaacggaccgcuggucucccugcugucguaccaacggcacaugcaggguagcuauguccggaacggauaaccgcugaaagcaucuaagcgggaagccagccccaagaugaguucucccacuguuuaucagguaagacucccggaagaccaccggguuaagaggccaggcgugcacgcauagcaauguguucagcggacuggugcucaucagucgaggucuugacca .<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<<[...((>>>>.....<<<<<<...<<.))...]..>>......>>>>>>...>>>....<<<....>>><<<<<....>>>>><<<<....>>>>>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<......<<.....>>.....>>>>...<<<...<<..<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>....>>..<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>..............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<.......>>>>>>>>>>...<............>.<<<<<<....<<<.<<<<<<<<<<..<<<...<<<....>>>...>>>...<<....>>...<<......>>.........>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<.....<<<<<......>>>>>......>>>...<<<<.<.<<........>>.>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<...<<<<.<<<<<<...<<<...<<<.<<<<......>>>>.>>>..>>.>...>>>>>>.>.>>>..>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><..<<<<<<<<...>>>>>>>>..>....>>>>>>..<<<<<<<.<<......<<<<<.<<....>>.>>>>>...>>.>>>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<<..>>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<...<<...<<<<....<<<<..<<<..<<<<<.<<<<.<<...[[....>>>>>><<<<<<<.<<..<<<<<<<<<<...<<.....>>.>>>>>>....>>>>..>>>>>>>>>...<<<<<....>>>>>....>>>>>...>>>...>>>>.........>>>>...>>......>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<...>>>>>>>>............<<<<<<<<<..<<...........>>..<<<<<<<.....<<<.....>>>.......>>>>>>>.<<<<<..<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<..>>>>>>>>>>>>>>...<<<<<<........>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.]].>>>>>>...>>>>>...>>>>.>>>>>....<<....<<<<<...........>>>>>....>>..>>>>.......>>>>>>>..<<<.....>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>>.. ((((((((......((((((((((.....(((..(((.((((((((......((((((.[...[[.))).....((((((...((.]]...]..))......))))))...)))....(((....)))(((((....)))))((((....))))))...((((((.....(...[..)......))))).).........((....))...((((......((.]...)).....))))...(((...((..(((...(((((......)))))[[(...).(((.....]])))...)))....))..((((((((..[......)))))))).......((((].[[[[))))...)))......)).)))).).))..............((....))....))......(..((((....))))............)).....)))))))))).....(.((((((((((..[....)))))))))).<.(.(........).).((((((....(((.((((((((((..(((...(((....)))...)))...((....))...((......)).........)))))))))))))..((.(...((((((.....((((((((((.((((....(((((......)))))....)<)))...(((..(.((........)).).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((..(((((.((((((...(((...(((.((((......)))).)))..)).)...)))))).).))).)))))))).))..(((((((.((......)).)))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{..(((..((...(((.........)))...)).....(..............)..)))....)))))))))).))..........]]].)....))))))))))...)))))))(..((((((((...))))))))..)....))))))(.(((((((.((......(((((.((....))])))))...)).)))))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((((((...((...((((....(((((.(((..(((((.((((.((...{{....))))))(((((((.((..((((((.(((...((.....)).))).))....))))..)))))))))...(((((....)))))....)))))...)))..)))))(..).....))))...))......))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.[..).....)))))((((((((...))))))))(...).......(((((((((.>.(...........)...(((((((.....(((.....))).......))))))).]((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..))))).......((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).[..(((((.....>].)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((..))))))))))))))...((((.(........).))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....((.((((.((..]]]]..)))))).)).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))....((....((((.....}.......))))....))..))))..]....)))))))(.((.......))....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))...))))))))). Crystal structure of compound 4d bound to large ribosomal subunit (50S) from Deinococcus radiodurans; 23S ribosomal RNA 4io9 Y 122 3.2 RF00001 URS000080E04E_1299 23414806 0003735 0005840 1299 cacccccgugcccauagcacuguggaaccaccccaccccaugccgaacugggucgugaaacacagcagcgccaaugauacucggaccgcagggucccggaaaagucggucagcgcggggguu .<<<<<<<<<<.....<<.<<<<<....<<<<<<<.............>>>>..>>>...>>>>>..>><<<.......<<.<<<<<....>>>>>.>>.......>>>..>>>>>>>>>>. .((((((((((.....((.(((((....(((.((....(.....)....))...)))...)))))..))(((.......((.(((((....))))).)).......)))..)))))))))). Crystal structure of compound 4d bound to large ribosomal subunit (50S) from Deinococcus radiodurans; 5S ribosomal RNA 4ioa X 2686 3.2 RF02540,RF02541 URS000080DEF1_1299 23414806 0003735 0005840 1299 ggucaagauaguaaggguccacgguggaugcccuggcgcuggagccgaugaaggacgcgauuaccugcgaaaagccccgacgagcuggagauacgcuuugacucggggauguccgaauggggaaacccaccucguaagagguauccgcaaggaugggaacucagggaacugaaacaucucaguaccugaaggagaagaaagagaauucgauuccguuaguagcggcgagcgaacccggaucagcccaaucaagccgaaguggcuggaaagcuacaccucagaaggugagaguccuguaggcgaacgagaggucguuguucgugaaacgaugacugaauccgcgcggaccaccgcgcaaggcuaaauacucccagugaccgauagcgcauaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaagagaaccugaaaccguggacuuacaagcagucauggcaccuuaugcguguuauggcgugccuauugaagcaugagccggcgacuuagaccugacgugcgagcuuaaguugaaaaacggaggcggagcgaaagcgaguccgaauagggcggcauuaguacgucgggcuagacucgaaaccaggugagcuaagcaugaccagguugaaacccccgugacagggggcggaggaccgaaccggugccugcugaaacagucucggaugaguuguguuuaggagugaaaagcuaaccgaaccuggagauagcuaguucuccccgaaauguauugagguacagccucggauguugaccauguccuguagagcacucacaaggcuaaaaccuuaugaaacuccgaaggggcacgcguuuaguccgggagugaggcugcgagagcuaacuuccguagccgagagggaaacaacccagaccaucagcuaaggucccuaaaugaucgcucagugguuaaggaugugucgucgcauagacagccaggagguuggcuuagaagcagccacccuucaaagagugcguaauagcucacuggucgagugacgaugcgccgaaaaugaucggggcucaagugaucuaccgaagcuauggauucaacucgcgaagcgaguugucugguaggggagcguucaguccgcggagaagccauaccggaaggagugguggagccgacugaagugcggaugccggcaugaguaacgauaaaagaagugagaaucuucuucgccguaaggacaaggguuccuggggaagggucguccgcccagggaaagucgggaccuaaggugaggccgaacggcgcagccgauggacagcaggucaagauuccugcaccgaucauguggagugauggagggacgcauuacgcuauccaaugccaagcuauggcuaugcugguugguacgcucaagggcgaucgggucagaaaaucuaccggucacaugccucagacguaucgggagcuuccucggaagcgaaguuggaaacgcgacggugccaagaaaagcuucuaaacguugaaacaugauugcccguaccgcaaaccgacacagguguccgagugucaaugcacuaaggcgcgcgagagaacccucguuaaggaacuuugcaaucucaccccguaacuucggaagaagggguccccacgcuucgcguggggcgcagugaauaggcccaggcgacuguuuaccaaaaucacagcacucugccaacacgaacaguggacguauagggugugacgccugcccggugccggaaggucaaguggagcggugcaagcugcgaaaugaagccccggugaacggcuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaggcguaacgaucugggcgcugucucaacgagggacucggugaaauugaauuggcuguaaagaugcggccuacccguagcaggacgaaaagaccccguggagcuuuacuauagucuggcauugggauucggguuucuagaaacuuggauuucuaaccugaaaaaucacuuucggggaccgugcuuggcggguaguuugacuggggcggucgccucccaaaauguaacggaggcgcccaaaggucaccucaagacgguuggaaaucgucuguagagcgcaaagguagaagguggcuugacugcgagacugacacgucgagcagggaggaaacucgggcuuagugaaccggugguaccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagaguccauaucggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgcuacgggcgcaggagaauugaggggaguugcuccuaguacgagaggaccggagugaacggaccgcuggucucccugcugucguaccaacggcacaugcaggguagcuauguccggaacggauaaccgcugaaagcaucuaagcgggaagccagccccaagaugaguucucccacuguuuaucagguaagacucccggaagaccaccggguuaagaggccaggcgugcacgcauagcaauguguucagcggacuggugcucaucagucgaggucuugacca <<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<...<<.))..))..>>......>>>>>>...>>>....<<<....>>><<<<<....>>>>><<<<....>>>>>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<......<<.....>>.....>>>>...<<<...<<..<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>....>>..<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>..............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<.......>>>>>>>>>>...<............>.<<<<<<....<<<.<<<<<<<<<<..<<<...<<<....>>>...>>>...<<....>>...<<......>>.........>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<.....<<<<<......>>>>>......>>>...<<<<.<.<<........>>.>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<...<<<<.<<<<<<...<<<...<<<.<<<<......>>>>.>>>..>>.>...>>>>>>.>.>>>..>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.......<.<<......>>.>.>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><..<<<<<<<<...>>>>>>>>..>....>>>>>>..<<<<<<<.<<......<<<<<.<<....>>.>>>>>...>>.>>>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<<..>>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<...<<...<<<<....<<<<..<<<..<<<<<.<<<<.<<...[[....>>>>>><<<<<<<.<<..<<<<<<<<<<...<<.....>>.>>>>>>....>>>>..>>>>>>>>>...<<<<<....>>>>>....>>>>>...>>>...>>>>.........>>>>...>>......>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<<<...>>>>>>>>............<<<<<<<<<..<<...........>>..<<<<<<<.....<<<.....>>>.......>>>>>>>.<<<<<..<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<..>>>>>>>>>>>>>>...<<<<<<........>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.]].>>>>>>...>>>>>...>>>>.>>>>>....<<....<<<<<...........>>>>>....>>..>>>>.......>>>>>>>..<<<.....>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>>>. ((((((((......((((((((((.....(((..(((.((((((((......((((((.[...[[.)))....(((((((...((.]]...]..))......)))))).).)))....(((....)))(((((....)))))((((....))))))...((((((.....(...[..)......))))).).........((....))...((((......((.]...)).....))))...(((...((..(((...(((((......)))))[[(...).(((.....]])))...)))....))..(((((((((.[.....))))))))).......((((].[[[[))))...)))......)).)))).).))..............((....))....))......(..((((....))))............)).....)))))))))).....(.((((((((((..[....)))))))))).<.(.(........).).((((((....(((.((((((((((..(((...(((....)))...)))...((....))...((......)).........)))))))))))))..((.(...((((((.....((((((((((.((((....(((((......)))))....)<)))...(((..(.((........)).).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..(((((.((((((...(((...(((.((((......)))).)))..)).)...)))))).).))).)))))))).)...(((((((.((......)).)))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(....(((.........)))....).....(....(......)..).)))))...)))))))))).))..........]]].)....))))))))))...)))))))(..((((((((...))))))))..)....))))))(.(((((((.((......(((((.((....))])))))...)).)))))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((((((...((...((((....(((((.(((..(((((.((((.((...{{....))))))(((((((.((..((((((((((...((.....)).))))))....))))..)))))))))...(((((....)))))....)))))...)))..)))))(..).....))))...))......))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.[..).....)))))((((((((...))))))))(...).......(((((((((.>.(...........)...(((((((.....(((.....))).......))))))).]((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..))))).......((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).[..(((((.....>].)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((.((((((((((..)))))))))).)))...((((.(........).))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))....((....((((.....}.......))))....))..))))..]....)))))))(.((.......))....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))...))))))))). Crystal structure of compound 4e bound to large ribosomal subunit (50S) from Deinococcus radiodurans; 23S ribosomal RNA 4ioa Y 122 3.2 RF00001 URS000080E04E_1299 23414806 0003735 0005840 1299 cacccccgugcccauagcacuguggaaccaccccaccccaugccgaacugggucgugaaacacagcagcgccaaugauacucggaccgcagggucccggaaaagucggucagcgcggggguu .<<<<<<<<<<.....<<.<<<<<....<<<<<<<.............>>>>..>>>...>>>>>..>><<<.......<<.<<<<<....>>>>>.>>.......>>>..>>>>>>>>>>. .((((((((((.....((.(((((....((((((....(.....)....)))..)))...)))))..))(((.......((.(((((....))))).)).......)))..)))))))))). Crystal structure of compound 4e bound to large ribosomal subunit (50S) from Deinococcus radiodurans; 5S ribosomal RNA 4ioc X 2686 3.6 RF02540,RF02541 URS000080DEF1_1299 23414806 0003735 0005840 1299 ggucaagauaguaaggguccacgguggaugcccuggcgcuggagccgaugaaggacgcgauuaccugcgaaaagccccgacgagcuggagauacgcuuugacucggggauguccgaauggggaaacccaccucguaagagguauccgcaaggaugggaacucagggaacugaaacaucucaguaccugaaggagaagaaagagaauucgauuccguuaguagcggcgagcgaacccggaucagcccaaucaagccgaaguggcuggaaagcuacaccucagaaggugagaguccuguaggcgaacgagaggucguuguucgugaaacgaugacugaauccgcgcggaccaccgcgcaaggcuaaauacucccagugaccgauagcgcauaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaagagaaccugaaaccguggacuuacaagcagucauggcaccuuaugcguguuauggcgugccuauugaagcaugagccggcgacuuagaccugacgugcgagcuuaaguugaaaaacggaggcggagcgaaagcgaguccgaauagggcggcauuaguacgucgggcuagacucgaaaccaggugagcuaagcaugaccagguugaaacccccgugacagggggcggaggaccgaaccggugccugcugaaacagucucggaugaguuguguuuaggagugaaaagcuaaccgaaccuggagauagcuaguucuccccgaaauguauugagguacagccucggauguugaccauguccuguagagcacucacaaggcuaaaaccuuaugaaacuccgaaggggcacgcguuuaguccgggagugaggcugcgagagcuaacuuccguagccgagagggaaacaacccagaccaucagcuaaggucccuaaaugaucgcucagugguuaaggaugugucgucgcauagacagccaggagguuggcuuagaagcagccacccuucaaagagugcguaauagcucacuggucgagugacgaugcgccgaaaaugaucggggcucaagugaucuaccgaagcuauggauucaacucgcgaagcgaguugucugguaggggagcguucaguccgcggagaagccauaccggaaggagugguggagccgacugaagugcggaugccggcaugaguaacgauaaaagaagugagaaucuucuucgccguaaggacaaggguuccuggggaagggucguccgcccagggaaagucgggaccuaaggugaggccgaacggcgcagccgauggacagcaggucaagauuccugcaccgaucauguggagugauggagggacgcauuacgcuauccaaugccaagcuauggcuaugcugguugguacgcucaagggcgaucgggucagaaaaucuaccggucacaugccucagacguaucgggagcuuccucggaagcgaaguuggaaacgcgacggugccaagaaaagcuucuaaacguugaaacaugauugcccguaccgcaaaccgacacagguguccgagugucaaugcacuaaggcgcgcgagagaacccucguuaaggaacuuugcaaucucaccccguaacuucggaagaagggguccccacgcuucgcguggggcgcagugaauaggcccaggcgacuguuuaccaaaaucacagcacucugccaacacgaacaguggacguauagggugugacgccugcccggugccggaaggucaaguggagcggugcaagcugcgaaaugaagccccggugaacggcuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaggcguaacgaucugggcgcugucucaacgagggacucggugaaauugaauuggcuguaaagaugcggccuacccguagcaggacgaaaagaccccguggagcuuuacuauagucuggcauugggauucggguuucuagaaacuuggauuucuaaccugaaaaaucacuuucggggaccgugcuuggcggguaguuugacuggggcggucgccucccaaaauguaacggaggcgcccaaaggucaccucaagacgguuggaaaucgucuguagagcgcaaagguagaagguggcuugacugcgagacugacacgucgagcagggaggaaacucgggcuuagugaaccggugguaccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagaguccauaucggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgcuacgggcgcaggagaauugaggggaguugcuccuaguacgagaggaccggagugaacggaccgcuggucucccugcugucguaccaacggcacaugcaggguagcuauguccggaacggauaaccgcugaaagcaucuaagcgggaagccagccccaagaugaguucucccacuguuuaucagguaagacucccggaagaccaccggguuaagaggccaggcgugcacgcauagcaauguguucagcggacuggugcucaucagucgaggucuugacca 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((((((((......((((((((((.....(((..(((.((((((((......((((((.[...[[.)))....(((((((...((.]]...]..))......)))))).).)))....(((....)))(((((....)))))((((....))))))...((((((.....(...[..)......))))).).........((....))...((((......((.]...)).....))))...(((...((..(((...(((((......)))))[[(...).((......]].))...)))....))..((((((((..[......)))))))).......((((].[[[[))))...)))......)).)))).).))..............((....))....))......(..((((....))))............)).....)))))))))).....(.((((((((((..[....)))))))))).<.(.(........).).((((((....(((.((((((((((..(((...(((....)))...)))...((....))...((......)).........)))))))))))))..((.(...((((((.....((((((((((.((((....(((((......)))))....)<)))...(((..(.((........)).).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((..(((((.((((((...(((...(((.((((......)))).)))..)).)...)))))).).))).)))))))).))..(((((((.((......)).)))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.........((..(....(((.........)))....).....(..............)..)).....)))))))))).))..........]]].)....))))))))))...)))))))(..((((.(((...))).))))..)....))))))(.(((((((.((......(((((.((....))])))))...)).)))))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((((((...((...((((....(((((.(((..(((((.((((.((...{{....))))))(((((((.((..(((.((.(((...((.....)).))).)).....)))..)))))))))...(((((....)))))....)))))...)))..)))))(..).....))))...))......))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((......[........)))))((((((((...))))))))(...).......(((((((((.>.(...........)...(((((((.....(((.....))).......))))))).]((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..))))).......((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).[..(((((.....>].)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((.((((.(((..))).)))).)))))...((((.(.......)..))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))....((....((((.............))))....))..))))..]....)))))))(.((.......))....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))...))))))))). Crystal structure of compound 4f bound to large ribosomal subunit (50S) from Deinococcus radiodurans; 23S ribosomal RNA 4ioc Y 122 3.6 RF00001 URS000080E04E_1299 23414806 0003735 0005840 1299 cacccccgugcccauagcacuguggaaccaccccaccccaugccgaacugggucgugaaacacagcagcgccaaugauacucggaccgcagggucccggaaaagucggucagcgcggggguu .<<<<<<<<<<.....<<.<<<<<....<<<<<<<.............>>>>..>>>...>>>>>..>><<<.......<<.<<<<<....>>>>>.>>.......>>>..>>>>>>>>>>. .((((((((((.....((.(((((....(((.(((...(.....)...)))...)))...)))))..))(((.......((.(((((....))))).)).......)))..)))))))))). Crystal structure of compound 4f bound to large ribosomal subunit (50S) from Deinococcus radiodurans; 5S ribosomal RNA 4j39 B 19 1.7 URS000080DE7E_32630 32630 cagcagcagccugcugcug ................... ................... Crystal structure of p19 in complex with double-helical 19mer RNA p(CAG)3C(CUG)3; 5'-R(P*CP*AP*GP*CP*AP*GP*CP*AP*GP*CP*CP*UP*GP*CP*UP*GP*CP*UP*G)-3' 4j50 A 19 1.65 URS000080E08C_32630 23441937 32630 uugggccagcagcaggucc ................... ................... Crystal Structure of an Expanded RNA CAG Repeat; RNA (5'-R(*UP*UP*GP*GP*GP*CP*CP*AP*GP*CP*AP*GP*CP*AP*GP*GP*UP*CP*C)-3') 4j50 B 19 1.65 URS000080E08C_32630 23441937 32630 uugggccagcagcaggucc ................... ................... Crystal Structure of an Expanded RNA CAG Repeat; RNA (5'-R(*UP*UP*GP*GP*GP*CP*CP*AP*GP*CP*AP*GP*CP*AP*GP*GP*UP*CP*C)-3') 4j5v B 19 2.15 URS000080E070_32630 32630 cagcagcagcccgccgccg ................... ................... Crystal structure of p19 in complex with double-helical RNA 19mer p(CAG)3C(CCG)3; 5'-R(P*CP*AP*GP*CP*AP*GP*CP*AP*GP*CP*CP*CP*GP*CP*CP*GP*CP*CP*G)-3' 4jgn E 20 1.86 URS000080E257_32630 32630 uugcugcugcugcugcugcu .................... .................... Crystal structure of RNA silencing suppressor p19 with 1nt-5'-overhanging double-helical RNA 20mer pUUG(CUG)5CU; 5'-R(P*UP*UP*GP*CP*UP*GP*CP*UP*GP*CP*UP*GP*CP*UP*GP*CP*UP*GP*CP*U)-3' 4jk0 B 21 2.3 URS000080E221_32630 32630 uuugcugcugcugcugcugcu ..................... ..................... Crystal structure of T89Q-mutant of RNA silencing suppressor p19 with 2nt-5'-overhanging double-helical RNA 21mer pUUUG(CUG)5CU; 5'-R(P*UP*UP*UP*GP*CP*UP*GP*CP*UP*GP*CP*UP*GP*CP*UP*GP*CP*UP*GP*CP*U)-3' 4jnx B 20 1.95 URS000080E27B_32630 32630 gcugcugcugcugcugcugc .................... .................... Crystal structure of RNA silencing suppressor p19 complexed with double-helical RNA 20mer pG(CUG)6C; 5'-R(P*GP*CP*UP*GP*CP*UP*GP*CP*UP*GP*CP*UP*GP*CP*UP*GP*CP*UP*GP*C)-3' 4jnx G 20 1.95 URS000080E27B_32630 32630 gcugcugcugcugcugcugc .................... .................... Crystal structure of RNA silencing suppressor p19 complexed with double-helical RNA 20mer pG(CUG)6C; 5'-R(P*GP*CP*UP*GP*CP*UP*GP*CP*UP*GP*CP*UP*GP*CP*UP*GP*CP*UP*GP*C)-3' 4jrd A 11 1.0 URS000080E35F_32630 23813654 32630 aaaaaaaaaaa ........... ........... Crystal structure of the parallel double-stranded helix of poly(A) RNA; RNA (5'-R(*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 4jrd B 11 1.0 URS000080E35F_32630 23813654 32630 aaaaaaaaaaa ........... ........... Crystal structure of the parallel double-stranded helix of poly(A) RNA; RNA (5'-R(*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 4jrt A 12 2.6 URS000080E077_32630 23722840 32630 ggguggugcggg ............ ............ Crystal structure of an A-form RNA duplex containing three GU base pairs; RNA (5'-R(P*GP*GP*GP*UP*GP*GP*UP*GP*CP*GP*GP*G)-3') 4jrt B 12 2.6 URS000080DFE3_32630 23722840 32630 ccugcacugccc ............ ............ Crystal structure of an A-form RNA duplex containing three GU base pairs; RNA (5'-R(P*CP*CP*UP*GP*CP*AP*CP*UP*GP*CP*CP*C)-3') 4jv5 A 1511 3.162 RF00177,RF01959,RF01960 URS000080E23E_300852 23812587 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggauuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucuuucu ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<<<<<<<<.......>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>....<<......>>...>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<...<<<.....>>>>......>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>.......... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((((((.(.......).))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))..........((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((.(....(((((((....)))))))....................)))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.((((((....(..............)......))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(.(((((......]...))))).)......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....))))))))).......... Crystal structures of pseudouridinilated stop codons with ASLs; 16S ribosomal RNA 4jv5 Y 10 3.162 URS000080E157_32630 23812587 32630 auuigaaauc <<.....>>. (.......). Crystal structures of pseudouridinilated stop codons with ASLs; ASL-tRNA 4jya A 1516 3.098 RF00177,RF01959,RF01960 URS000080E30C_300852 23812587 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggauuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucaccuccuuuc ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<.......>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>....<<.....>.>...>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((((((.(.......).))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))..........((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((.(....(((((((....)))))))....................)))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.((((((....(..............)......))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((.((((((...(.((((....(((....))).)))).)..)))))).))))))..))).))))..).))...)..)..(((((((((....)))))))))............... Crystal structures of pseudouridinilated stop codons with ASLs; 16S ribosomal RNA 4jya Y 10 3.098 URS000080E301_32630 23812587 32630 auugaagauu <<.....>>. (.......). Crystal structures of pseudouridinilated stop codons with ASLs; ASL-tRNA 4k0k A 1511 3.4 RF00177,RF01959,RF01960 URS000080E23E_300852 23812587 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggauuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucuuucu ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<.......>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<.<..<<<<<<<....>>>>>>>....<<......>>...>.>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<....<<.....>>..>.....>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<...<<<<....>>>>...>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<...<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>...>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.......... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((((((.(.......).))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(.(((....))).).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))..........((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((......(((((((....))))))).....................))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.((((((...((..............).)....))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....))))))))).......... Crystal structure of the Thermus thermophilus 30S ribosomal subunit complexed with a serine-ASL and mRNA containing a stop codon; 16S ribosomal RNA 4k0k Y 10 3.4 URS000080E248_300852 23812587 300852 auuigaaauc <<.....>>. (.......). Crystal structure of the Thermus thermophilus 30S ribosomal subunit complexed with a serine-ASL and mRNA containing a stop codon; RNA-ASL 4k31 B 22 1.415 URS000080DEED_38568 23898171 38568 ugcgucguuccggaaaagucgc ...................... ...................... Crystal structure of apramycin bound to the leishmanial rRNA A-site; RNA (5'-R(*UP*UP*GP*CP*GP*UP*CP*GP*UP*UP*CP*CP*GP*GP*AP*AP*AP*AP*GP*UP*CP*GP*C)-3') 4k31 C 22 1.415 URS000080DEED_38568 23898171 38568 ugcgucguuccggaaaagucgc ...................... ...................... Crystal structure of apramycin bound to the leishmanial rRNA A-site; RNA (5'-R(*UP*UP*GP*CP*GP*UP*CP*GP*UP*UP*CP*CP*GP*GP*AP*AP*AP*AP*GP*UP*CP*GP*C)-3') 4k32 A 21 2.5 URS000080DEED_38568 23898171 38568 gcgucguuccggaaaagucgc ..................... ..................... Crystal structure of geneticin bound to the leishmanial rRNA A-site; RNA (5'-R(*UP*UP*GP*CP*GP*UP*CP*GP*UP*UP*CP*CP*GP*GP*AP*AP*AP*AP*GP*UP*CP*GP*C)-3') 4k32 B 21 2.5 URS000080DEED_38568 23898171 38568 gcgucguuccggaaaagucgc ..................... ..................... Crystal structure of geneticin bound to the leishmanial rRNA A-site; RNA (5'-R(*UP*UP*GP*CP*GP*UP*CP*GP*UP*UP*CP*CP*GP*GP*AP*AP*AP*AP*GP*UP*CP*GP*C)-3') 4k4s B 17 2.4 URS000080E0C7_32630 23667424 32630 uccaggucucucgcgaa ................. ................. Poliovirus polymerase elongation complex (r3_form); RNA (5'-R(*AP*AP*GP*UP*CP*UP*CP*CP*AP*GP*GP*UP*CP*UP*CP*UP*CP*GP*CP*GP*AP*AP*A)-3') 4k4s C 13 2.4 URS000080E237_32630 23667424 32630 uguucgcgagaga ............. ............. Poliovirus polymerase elongation complex (r3_form); RNA (5'-R(*UP*GP*UP*UP*CP*GP*CP*GP*AP*GP*AP*GP*A)-3') 4k4s F 17 2.4 URS000080E0C7_32630 23667424 32630 uccaggucucucgcgaa ................. ................. Poliovirus polymerase elongation complex (r3_form); RNA (5'-R(*AP*AP*GP*UP*CP*UP*CP*CP*AP*GP*GP*UP*CP*UP*CP*UP*CP*GP*CP*GP*AP*AP*A)-3') 4k4s G 13 2.4 URS000080E237_32630 23667424 32630 uguucgcgagaga ............. ............. Poliovirus polymerase elongation complex (r3_form); RNA (5'-R(*UP*GP*UP*UP*CP*GP*CP*GP*AP*GP*AP*GP*A)-3') 4k4t B 17 2.75 URS000080DD5A_32630 23667424 32630 uccaggucucucggaaa ................. ................. Poliovirus polymerase elongation complex (r4_form); RNA (5'-R(*AP*AP*GP*UP*CP*UP*CP*CP*AP*GP*GP*UP*CP*UP*CP*UP*CP*GP*GP*AP*AP*A)-3') 4k4t C 12 2.75 URS000080E152_32630 23667424 32630 uguuccgagaga ............ ............ Poliovirus polymerase elongation complex (r4_form); RNA (5'-R(P*UP*GP*UP*UP*CP*CP*GP*AP*GP*AP*GP*A)-3') 4k4t F 17 2.75 URS000080DD5A_32630 23667424 32630 uccaggucucucggaaa ................. ................. Poliovirus polymerase elongation complex (r4_form); RNA (5'-R(*AP*AP*GP*UP*CP*UP*CP*CP*AP*GP*GP*UP*CP*UP*CP*UP*CP*GP*GP*AP*AP*A)-3') 4k4t G 12 2.75 URS000080E152_32630 23667424 32630 uguuccgagaga ............ ............ Poliovirus polymerase elongation complex (r4_form); RNA (5'-R(P*UP*GP*UP*UP*CP*CP*GP*AP*GP*AP*GP*A)-3') 4k4u B 19 2.85 URS000080E26A_32630 23667424 32630 ccaggucucucucgucgaa ................... ................... Poliovirus polymerase elongation complex (r5_form); RNA (5'-R(*AP*AP*GP*UP*CP*UP*CP*CP*AP*GP*GP*UP*CP*UP*CP*UP*CP*UP*CP*GP*UP*CP*GP*AP*AP*A)-3') 4k4u C 15 2.85 URS000080DFB4_32630 23667424 32630 guucgacgagagaga ............... ............... Poliovirus polymerase elongation complex (r5_form); RNA (5'-R(*UP*GP*UP*UP*CP*GP*AP*CP*GP*AP*GP*AP*GP*AP*GP*A)-3') 4k4u F 19 2.85 URS000080E26A_32630 23667424 32630 ccaggucucucucgucgaa ................... ................... Poliovirus polymerase elongation complex (r5_form); RNA (5'-R(*AP*AP*GP*UP*CP*UP*CP*CP*AP*GP*GP*UP*CP*UP*CP*UP*CP*UP*CP*GP*UP*CP*GP*AP*AP*A)-3') 4k4u G 15 2.85 URS000080DFB4_32630 23667424 32630 guucgacgagagaga ............... ............... Poliovirus polymerase elongation complex (r5_form); RNA (5'-R(*UP*GP*UP*UP*CP*GP*AP*CP*GP*AP*GP*AP*GP*AP*GP*A)-3') 4k4v B 13 2.63 URS000080E26A_32630 23667424 32630 aggucucucucgu ............. ............. Poliovirus polymerase elongation complex (r5+1_form); RNA (5'-R(*AP*AP*GP*UP*CP*UP*CP*CP*AP*GP*GP*UP*CP*UP*CP*UP*CP*UP*CP*GP*UP*CP*GP*AP*AP*A)-3') 4k4v C 10 2.63 URS000080DFD6_32630 23667424 32630 cgagagagac .......... .......... Poliovirus polymerase elongation complex (r5+1_form); DNA/RNA (5'-R(*UP*GP*UP*UP*CP*GP*AP*CP*GP*AP*GP*AP*GP*AP*GP*A)-D(P*C)-3') 4k4v F 13 2.63 URS000080E26A_32630 23667424 32630 aggucucucucgu ............. ............. Poliovirus polymerase elongation complex (r5+1_form); RNA (5'-R(*AP*AP*GP*UP*CP*UP*CP*CP*AP*GP*GP*UP*CP*UP*CP*UP*CP*UP*CP*GP*UP*CP*GP*AP*AP*A)-3') 4k4v G 10 2.63 URS000080DFD6_32630 23667424 32630 cgagagagac .......... .......... Poliovirus polymerase elongation complex (r5+1_form); DNA/RNA (5'-R(*UP*GP*UP*UP*CP*GP*AP*CP*GP*AP*GP*AP*GP*AP*GP*A)-D(P*C)-3') 4k4w B 21 2.69 URS000080DEB1_32630 23667424 32630 gggccaggucucucucgucga ..................... ..................... Poliovirus polymerase elongation complex (r5+2_form); RNA (5'-R(P*GP*GP*GP*AP*GP*AP*UP*GP*AP*AP*AP*GP*UP*CP*UP*CP*CP*AP*GP*GP*UP*CP*UP*CP*UP*CP*UP*CP*GP*UP*CP*GP*AP*AP*A)-3') 4k4w C 14 2.69 URS000080E24A_32630 23667424 32630 cgacgagagagacc .............. .............. Poliovirus polymerase elongation complex (r5+2_form); RNA (5'-R(*UP*GP*UP*UP*CP*GP*AP*CP*GP*AP*GP*AP*GP*AP*GP*AP*CP*C)-3') 4k4w G 15 2.69 URS000080E24A_32630 23667424 32630 ucgacgagagagacc ............... ............... Poliovirus polymerase elongation complex (r5+2_form); RNA (5'-R(*UP*GP*UP*UP*CP*GP*AP*CP*GP*AP*GP*AP*GP*AP*GP*AP*CP*C)-3') 4k4w F 21 2.69 URS000080DEB1_32630 23667424 32630 gggccaggucucucucgucga ..................... ..................... Poliovirus polymerase elongation complex (r5+2_form); RNA (5'-R(P*GP*GP*GP*AP*GP*AP*UP*GP*AP*AP*AP*GP*UP*CP*UP*CP*CP*AP*GP*GP*UP*CP*UP*CP*UP*CP*UP*CP*GP*UP*CP*GP*AP*AP*A)-3') 4k4x B 16 2.37 URS000080E1E0_32630 23667424 32630 caggucucucgucgaa ................ ................ Coxsackievirus B3 polymerase elongation complex (r2_form), rna; RNA (5'-R(*AP*AP*GP*UP*CP*UP*CP*CP*AP*GP*GP*UP*CP*UP*CP*UP*CP*GP*UP*CP*GP*AP*AP*A)-3') 4k4x C 13 2.37 URS000080DF73_32630 23667424 32630 guucgacgagaga ............. ............. Coxsackievirus B3 polymerase elongation complex (r2_form), rna; RNA (5'-R(*UP*GP*UP*UP*CP*GP*AP*CP*GP*AP*GP*AP*GP*A)-3') 4k4x F 16 2.37 URS000080E1E0_32630 23667424 32630 caggucucucgucgaa ................ ................ Coxsackievirus B3 polymerase elongation complex (r2_form), rna; RNA (5'-R(*AP*AP*GP*UP*CP*UP*CP*CP*AP*GP*GP*UP*CP*UP*CP*UP*CP*GP*UP*CP*GP*AP*AP*A)-3') 4k4x G 13 2.37 URS000080DF73_32630 23667424 32630 guucgacgagaga ............. ............. Coxsackievirus B3 polymerase elongation complex (r2_form), rna; RNA (5'-R(*UP*GP*UP*UP*CP*GP*AP*CP*GP*AP*GP*AP*GP*A)-3') 4k4x J 16 2.37 URS000080E1E0_32630 23667424 32630 caggucucucgucgaa ................ ................ Coxsackievirus B3 polymerase elongation complex (r2_form), rna; RNA (5'-R(*AP*AP*GP*UP*CP*UP*CP*CP*AP*GP*GP*UP*CP*UP*CP*UP*CP*GP*UP*CP*GP*AP*AP*A)-3') 4k4x K 13 2.37 URS000080DF73_32630 23667424 32630 guucgacgagaga ............. ............. Coxsackievirus B3 polymerase elongation complex (r2_form), rna; RNA (5'-R(*UP*GP*UP*UP*CP*GP*AP*CP*GP*AP*GP*AP*GP*A)-3') 4k4x N 16 2.37 URS000080E1E0_32630 23667424 32630 caggucucucgucgaa ................ ................ Coxsackievirus B3 polymerase elongation complex (r2_form), rna; RNA (5'-R(*AP*AP*GP*UP*CP*UP*CP*CP*AP*GP*GP*UP*CP*UP*CP*UP*CP*GP*UP*CP*GP*AP*AP*A)-3') 4k4x O 13 2.37 URS000080DF73_32630 23667424 32630 guucgacgagaga ............. ............. Coxsackievirus B3 polymerase elongation complex (r2_form), rna; RNA (5'-R(*UP*GP*UP*UP*CP*GP*AP*CP*GP*AP*GP*AP*GP*A)-3') 4k4y B 18 2.72 URS000080E1E0_32630 23667424 32630 cuccaggucucucgucga .................. .................. Coxsackievirus B3 polymerase elongation complex (r2+1_form); RNA (5'-R(*AP*AP*GP*UP*CP*UP*CP*CP*AP*GP*GP*UP*CP*UP*CP*UP*CP*GP*UP*CP*GP*AP*AP*A)-3') 4k4y C 12 2.72 URS000080E28B_32630 23667424 32630 ucgacgagagan ............ ............ Coxsackievirus B3 polymerase elongation complex (r2+1_form); DNA/RNA (5'-R(*UP*GP*UP*UP*CP*GP*AP*CP*GP*AP*GP*AP*GP*AP*(DOC))-3') 4k4y F 17 2.72 URS000080E1E0_32630 23667424 32630 uccaggucucucgucga ................. ................. Coxsackievirus B3 polymerase elongation complex (r2+1_form); RNA (5'-R(*AP*AP*GP*UP*CP*UP*CP*CP*AP*GP*GP*UP*CP*UP*CP*UP*CP*GP*UP*CP*GP*AP*AP*A)-3') 4k4y G 12 2.72 URS000080E28B_32630 23667424 32630 ucgacgagagan ............ ............ Coxsackievirus B3 polymerase elongation complex (r2+1_form); DNA/RNA (5'-R(*UP*GP*UP*UP*CP*GP*AP*CP*GP*AP*GP*AP*GP*AP*(DOC))-3') 4k4y J 18 2.72 URS000080E1E0_32630 23667424 32630 cuccaggucucucgucga .................. .................. Coxsackievirus B3 polymerase elongation complex (r2+1_form); RNA (5'-R(*AP*AP*GP*UP*CP*UP*CP*CP*AP*GP*GP*UP*CP*UP*CP*UP*CP*GP*UP*CP*GP*AP*AP*A)-3') 4k4y K 12 2.72 URS000080E28B_32630 23667424 32630 ucgacgagagan ............ ............ Coxsackievirus B3 polymerase elongation complex (r2+1_form); DNA/RNA (5'-R(*UP*GP*UP*UP*CP*GP*AP*CP*GP*AP*GP*AP*GP*AP*(DOC))-3') 4k4y N 17 2.72 URS000080E1E0_32630 23667424 32630 uccaggucucucgucga ................. ................. Coxsackievirus B3 polymerase elongation complex (r2+1_form); RNA (5'-R(*AP*AP*GP*UP*CP*UP*CP*CP*AP*GP*GP*UP*CP*UP*CP*UP*CP*GP*UP*CP*GP*AP*AP*A)-3') 4k4y O 12 2.72 URS000080E28B_32630 23667424 32630 ucgacgagagan ............ ............ Coxsackievirus B3 polymerase elongation complex (r2+1_form); DNA/RNA (5'-R(*UP*GP*UP*UP*CP*GP*AP*CP*GP*AP*GP*AP*GP*AP*(DOC))-3') 4k4z B 17 2.17 URS000080E1E0_32630 23667424 32630 ccaggucucucgucgaa ................. ................. Coxsackievirus B3 polymerase elongation complex (r2_Mg_form); RNA (5'-R(*AP*AP*GP*UP*CP*UP*CP*CP*AP*GP*GP*UP*CP*UP*CP*UP*CP*GP*UP*CP*GP*AP*AP*A)-3') 4k4z C 13 2.17 URS000080DF73_32630 23667424 32630 guucgacgagaga ............. ............. Coxsackievirus B3 polymerase elongation complex (r2_Mg_form); RNA (5'-R(*UP*GP*UP*UP*CP*GP*AP*CP*GP*AP*GP*AP*GP*A)-3') 4k4z F 18 2.17 URS000080E1E0_32630 23667424 32630 uccaggucucucgucgaa .................. .................. Coxsackievirus B3 polymerase elongation complex (r2_Mg_form); RNA (5'-R(*AP*AP*GP*UP*CP*UP*CP*CP*AP*GP*GP*UP*CP*UP*CP*UP*CP*GP*UP*CP*GP*AP*AP*A)-3') 4k4z G 13 2.17 URS000080DF73_32630 23667424 32630 guucgacgagaga ............. ............. Coxsackievirus B3 polymerase elongation complex (r2_Mg_form); RNA (5'-R(*UP*GP*UP*UP*CP*GP*AP*CP*GP*AP*GP*AP*GP*A)-3') 4k4z J 18 2.17 URS000080E1E0_32630 23667424 32630 uccaggucucucgucgaa .................. .................. Coxsackievirus B3 polymerase elongation complex (r2_Mg_form); RNA (5'-R(*AP*AP*GP*UP*CP*UP*CP*CP*AP*GP*GP*UP*CP*UP*CP*UP*CP*GP*UP*CP*GP*AP*AP*A)-3') 4k4z K 13 2.17 URS000080DF73_32630 23667424 32630 guucgacgagaga ............. ............. Coxsackievirus B3 polymerase elongation complex (r2_Mg_form); RNA (5'-R(*UP*GP*UP*UP*CP*GP*AP*CP*GP*AP*GP*AP*GP*A)-3') 4k4z N 17 2.17 URS000080E1E0_32630 23667424 32630 ccaggucucucgucgaa ................. ................. Coxsackievirus B3 polymerase elongation complex (r2_Mg_form); RNA (5'-R(*AP*AP*GP*UP*CP*UP*CP*CP*AP*GP*GP*UP*CP*UP*CP*UP*CP*GP*UP*CP*GP*AP*AP*A)-3') 4k4z O 13 2.17 URS000080DF73_32630 23667424 32630 guucgacgagaga ............. ............. Coxsackievirus B3 polymerase elongation complex (r2_Mg_form); RNA (5'-R(*UP*GP*UP*UP*CP*GP*AP*CP*GP*AP*GP*AP*GP*A)-3') 4k50 B 33 2.93 URS000080DF72_32630 23667424 32630 aggagaugaaagucuccaggucucucguccgga .<<<<<<....>>>>>>................ .((((((....))))))................ Rhinovirus 16 polymerase elongation complex (r1_form); RNA (33-MER) 4k50 C 14 2.93 URS000080E1D2_32630 23667424 32630 gcccggacgagaga .............. .............. Rhinovirus 16 polymerase elongation complex (r1_form); RNA (5'-R(P*GP*CP*CP*CP*GP*GP*AP*CP*GP*AP*GP*AP*GP*A)-3') 4k50 F 31 2.93 URS000080DF72_32630 23667424 32630 ggagaugaaagucuccaggucucucguccgg <<<<<<....>>>>>>............... ((((((....))))))............... Rhinovirus 16 polymerase elongation complex (r1_form); RNA (33-MER) 4k50 G 14 2.93 URS000080E1D2_32630 23667424 32630 gcccggacgagaga .............. .............. Rhinovirus 16 polymerase elongation complex (r1_form); RNA (5'-R(P*GP*CP*CP*CP*GP*GP*AP*CP*GP*AP*GP*AP*GP*A)-3') 4k50 J 33 2.93 URS000080DF72_32630 23667424 32630 aggagaugaaagucuccaggucucucguccgga .<<<<<<....>>>>>>................ .((((((....))))))................ Rhinovirus 16 polymerase elongation complex (r1_form); RNA (33-MER) 4k50 K 14 2.93 URS000080E1D2_32630 23667424 32630 gcccggacgagaga .............. .............. Rhinovirus 16 polymerase elongation complex (r1_form); RNA (5'-R(P*GP*CP*CP*CP*GP*GP*AP*CP*GP*AP*GP*AP*GP*A)-3') 4k50 N 32 2.93 URS000080DF72_32630 23667424 32630 ggagaugaaagucuccaggucucucguccgga <<<<<<....>>>>>>................ ((((((....))))))................ Rhinovirus 16 polymerase elongation complex (r1_form); RNA (33-MER) 4k50 O 14 2.93 URS000080E1D2_32630 23667424 32630 gcccggacgagaga .............. .............. Rhinovirus 16 polymerase elongation complex (r1_form); RNA (5'-R(P*GP*CP*CP*CP*GP*GP*AP*CP*GP*AP*GP*AP*GP*A)-3') 4khp A 1506 3.1 RF00177,RF01959,RF01960 URS000080E2C4_300852 23702293 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggauuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggauc ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<.......>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>....<<......>>...>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<....<<.....>>.>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((((((.(.......).))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))..........((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((.(....(((((((....)))))))....................)))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.((((((....(..............)......))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))..... Structure of the Thermus thermophilus 30S ribosomal subunit in complex with de-6-MSA-pactamycin; 16S Ribosomal RNA 4knq B 20 1.82 URS000080DF48_32630 32630 ccgccgccgccgccgccgcg .................... .................... Crystal structure of 1nt-5'-overhanging double-helical CCG-repetitive RNA 20mer complexed with RSS p19; 5'-R(P*CP*CP*GP*CP*CP*GP*CP*CP*GP*CP*CP*GP*CP*CP*GP*CP*CP*GP*CP*G)-3' 4kq0 B 19 2.1 URS000080DE94_32630 32630 ggcggcggcggcggcggcc ................... ................... Crystal structure of double-helical CGG-repetitive RNA 19mer complexed with RSS p19; 5'-R(P*GP*GP*CP*GP*GP*CP*GP*GP*CP*GP*GP*CP*GP*GP*CP*GP*GP*CP*C)-3' 4kq0 E 19 2.1 URS000080DE94_32630 32630 ggcggcggcggcggcggcc ................... ................... Crystal structure of double-helical CGG-repetitive RNA 19mer complexed with RSS p19; 5'-R(P*GP*GP*CP*GP*GP*CP*GP*GP*CP*GP*GP*CP*GP*GP*CP*GP*GP*CP*C)-3' 4ktg B 19 1.92 URS000080E26C_32630 32630 gcggcggcggcggcggcgc ................... ................... Crystal structure of double-helical GGC-repetitive RNA 19mer complexed with RSS p19; 5'-R(P*GP*CP*GP*GP*CP*GP*GP*CP*GP*GP*CP*GP*GP*CP*GP*GP*CP*GP*C)-3' 4ktg E 19 1.92 URS000080E26C_32630 32630 gcggcggcggcggcggcgc ................... ................... Crystal structure of double-helical GGC-repetitive RNA 19mer complexed with RSS p19; 5'-R(P*GP*CP*GP*GP*CP*GP*GP*CP*GP*GP*CP*GP*GP*CP*GP*GP*CP*GP*C)-3' 4kyy A 17 2.35 URS000080DED2_32630 32630 uucgguuuugauccgga ................. ................. Crystal Structure of RNA 17-mer UUCGGUUUUGAUCCGGA duplex; RNA 17-mer 4kyy B 17 2.35 URS000080DED2_32630 32630 uucgguuuugauccgga ................. ................. Crystal Structure of RNA 17-mer UUCGGUUUUGAUCCGGA duplex; RNA 17-mer 4kz2 A 18 3.05 URS000080DDDD_32630 23884902 32630 uugccauguguauguggg .................. .................. Crystal Structure of phi29 pRNA 3WJ Core; phi29 pRNA 3WJ core RNA 18 mer 4kz2 B 20 3.05 URS000080E1B5_32630 23884902 32630 cccacauacuuuguugaucc .................... .................... Crystal Structure of phi29 pRNA 3WJ Core; phi29 pRNA 3WJ core RNA 20 mer 4kz2 C 16 3.05 URS000080E371_32630 23884902 32630 ggaucaaucauggcaa ................ ................ Crystal Structure of phi29 pRNA 3WJ Core; phi29 pRNA 3WJ core RNA 16 mer 4kzz i 1797 7.0305 RF01960,RF01959,RF00177 URS000015960A_9986 23873042 0003735 0005840 9986 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucgcuccucuccuacuuggauaacugugguaauucuagagcuaauacaugccgacggcgcugacucccuuugugugggaugcgugcauuuaucagaucaaaaccaacccggucagccuccccgccggccggggggguggggcggcggcuuuggugacucuagauaaccucgggccgaucgcagcccuccguggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggucgcagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuuggagggugcguagcgggccaccgcccguccccgcccugccuccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauucugugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagaugucggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggcccgccggggucggcccacggcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<...[[[[>>>>>[[[.((((((.....{{.........[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[......{{....[[[....................<<.....<<.<<<.....>>>.>>......>>.........<<<...<<.<......>.>>...>>>.[[..(((((.....<<<<<<<<<<<<.<...<.<<<..........>..>.>.>.....>>>>..............)))))......]]...<<<<.<<<......>>>.>>>>....]]]...}}....]]].<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>......}}.......<<<<<<<<<.<<<....>>>.>.>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..)))))).]]]............{{.......{{...[[[.[[....<..<<<...<..<........>..>...>>>..>...<<.<...>.>>..<<<<<..<.......<<...<.......>.<<<<.......>>>>...>>......>..>>..>>>.......[[....(((((((.....>>>>>>>>>.)))))))...]]....]]....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>.>.>>.......<<....>>...>>>>..>..>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<..}}>>...>>.....>>>.....<<<......<<<......>>>....>>>..]]]]..<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<......<<<<<<.......<<.<<<........>>>.>>.....>>>>>>.<.<<.<<<..<<<<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<....<<<..<<<<....>>>>.>>>....>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>...>.>>>>>>>>.....>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>............<<<<<..........>>>>>...........>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<.<<<<<<<<<<<.....>>>>>>>>>>.>...>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>.........<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((..((....((....((..........))...)){))......(((.......(((.(....((....(((................{...((.....((.(((.....))).))......))..........((...(..(......)..)...))..((..(((((.....[[[[[[[[[(((.....(...(..........)......)......)))....(......)..)))))......)).(}((((.(((......))).)))))...)))...))..).))).(((.<..(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)...)).).....(((.(((((.(((....))).).))))..)))......((..(...........)..)).........((((([[......((((.....((..]])).......)))).)))))..)))))).)))..{......(.({{...(.(.((...(((..(....(...((...(..(........)..)...))...)...((.(...).))..(((((..(.......((..((.......))..((.......)).....))......)..))..))).......((.(..(.((.((.....]]]]]]]]].)).)).)..)))....)....(((.((...(...((((..((..((((((((...((........))......))))))))..)).......((....))...))))..)...))..))..))))...)).)....((((((....(...((((.........))))...).))))))..........(((.((..((..(.((((((.(((........))))))))).)..))....((..}}))...))...}.))))).).(((....>.((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((.(.....(..((.(((........))).))....).).)))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((...(...((((..((((..(.(((.(.(((....)))).))).)..))))..))))..)..(..(((((.....)))))....)...)))....))).))).....).))))).....))))))...)).)))).))).(...((.(((........(.......(((.(.((....)).).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....((((((.(.......).))))))......))...)))))))))).))..(.(..((.(..((((.((..(.((((.(((.(((..(.((..(...((.(..(((..(((.((.....)).)))..)).)....).))...)..)).)..))).))).)))))..)).))))...).))...)..)..(((((((((....)))))))))......... Rabbit 40S ribosomal subunit in complex with mRNA, initiator tRNA and eIF1A; 18S Ribosomal RNA 4kzz j 75 7.0305 RF00005 URS0000326EAC_9606 23873042 0030533 0006412 9606 agcagaguggcgcagcggaagcgugcugggcccauaacccagaggucgauggaucgaaaccauccucugcuacca <<<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((....[..)))).(((((.......))))).....(((((..]....)))))))))))).... Rabbit 40S ribosomal subunit in complex with mRNA, initiator tRNA and eIF1A; initiator Met-RNA-i 4kzz k 13 7.0305 23873042 32630 caacaaauguuuc ............. ............. Rabbit 40S ribosomal subunit in complex with mRNA, initiator tRNA and eIF1A; mRNA 4l47 QA 1500 3.22 RF00177,RF01959,RF01960 URS000080E226_300852 25128388 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggggucuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<...>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<......>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).(((......)))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((((..(((((((....)))))))...((((....))))..))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Crystal Structure of Frameshift Suppressor tRNA SufA6 Bound to Codon CCC-U on the Ribosome; 16S rRNA 4l47 QV 77 3.22 RF00005 URS000041AF00_300852 25128388 0030533 0006412 300852 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal Structure of Frameshift Suppressor tRNA SufA6 Bound to Codon CCC-U on the Ribosome; P-site tRNA fMet 4l47 QY 14 3.22 25128388 32630 ucguucggngacga <<<<......>>>> (((........))) Crystal Structure of Frameshift Suppressor tRNA SufA6 Bound to Codon CCC-U on the Ribosome; messenger RNA 4l47 RA 2882 3.22 RF02540,RF02541,RF00002 URS000080DFFB_300852 25128388 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<..>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[[)))...].((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....()....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((...((((((......)))).))...))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......(((((.(((..(((.........)))..))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........(((((..(((......((((((((....))))))))...)))............)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.((((.....))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal Structure of Frameshift Suppressor tRNA SufA6 Bound to Codon CCC-U on the Ribosome; 23S rRNA 4l47 RB 120 3.22 RF00001 URS00005F2F4B_300852 25128388 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> (((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).))))))))))) Crystal Structure of Frameshift Suppressor tRNA SufA6 Bound to Codon CCC-U on the Ribosome; 5S rRNA 4l47 XA 1500 3.22 RF00177,RF01959,RF01960 URS000080E226_300852 25128388 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggggacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<...>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<......>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<......>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).(((.(...))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((((..(((((((....)))))))...((((....))))..))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Crystal Structure of Frameshift Suppressor tRNA SufA6 Bound to Codon CCC-U on the Ribosome; 16S rRNA 4l47 XV 77 3.22 RF00005 URS000041AF00_300852 25128388 0030533 0006412 300852 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal Structure of Frameshift Suppressor tRNA SufA6 Bound to Codon CCC-U on the Ribosome; P-site tRNA fMet 4l47 XY 14 3.22 25128388 32630 ucguucggngacga <<<<......>>>> (((........))) Crystal Structure of Frameshift Suppressor tRNA SufA6 Bound to Codon CCC-U on the Ribosome; messenger RNA 4l47 YA 2883 3.22 RF02540,RF02541,RF00002 URS000080DFFB_300852 25128388 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<..>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<..>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[[)))...].((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((..)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....()....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((...((((((......)))).))...))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......(((((.(((..(((.........)))..))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........(((((..(((......((((((((....))))))))...)))............)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.((((.....))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal Structure of Frameshift Suppressor tRNA SufA6 Bound to Codon CCC-U on the Ribosome; 23S rRNA 4l47 YB 120 3.22 RF00001 URS00005F2F4B_300852 25128388 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> (((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).))))))))))) Crystal Structure of Frameshift Suppressor tRNA SufA6 Bound to Codon CCC-U on the Ribosome; 5S rRNA 4l71 QA 1500 3.9 RF00177,RF01959,RF01960 URS000080E226_300852 25128388 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggggucuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<...>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<......>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(.((((((..(((((((....)))))))...((((....))))..)))))).)).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Crystal Structure of Frameshift Suppressor tRNA SufA6 Bound to Codon CCC-A on the Ribosome; 16S Ribosomal RNA 4l71 RA 2882 3.9 RF02540,RF02541,RF00002 URS000080DFFB_300852 25128388 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<..>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[[)))...].((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.((((((((......((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))..))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....()....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((...((((((......)))).))...))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......(((((.(((..(((.........)))..))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........(((((..(((......((((((((....))))))))...)))............)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.((((.....))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal Structure of Frameshift Suppressor tRNA SufA6 Bound to Codon CCC-A on the Ribosome; 23S Ribosomal RNA 4l71 RB 120 3.9 RF00001 URS00005F2F4B_300852 25128388 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> (((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).))))))))))) Crystal Structure of Frameshift Suppressor tRNA SufA6 Bound to Codon CCC-A on the Ribosome; 5S Ribosomal RNA 4l71 XA 1500 3.9 RF00177,RF01959,RF01960 URS000080E226_300852 25128388 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggggacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<...>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>....<<<<.<<<<<....>>>>>.>>>>...<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<......>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<......>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).(((.(...))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((......((((((((..(((((((....)))))))...((((....))))..))))))))..((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...(...(((.....))).)....))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Crystal Structure of Frameshift Suppressor tRNA SufA6 Bound to Codon CCC-A on the Ribosome; 16S Ribosomal RNA 4l71 YA 2883 3.9 RF02540,RF02541,RF00002 URS000080DFFB_300852 25128388 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<..>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<..>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<<<<<<<<...<<.......>>...>>>>>>>..>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[[)))...].((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((..)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....()....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((...((((((......)))).))...)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......(((((.(((..(((.........)))..))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........(((((..(((......((((((((....))))))))...)))............)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.((((.....))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal Structure of Frameshift Suppressor tRNA SufA6 Bound to Codon CCC-A on the Ribosome; 23S Ribosomal RNA 4l71 YB 120 3.9 RF00001 URS00005F2F4B_300852 25128388 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> (((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).))))))))))) Crystal Structure of Frameshift Suppressor tRNA SufA6 Bound to Codon CCC-A on the Ribosome; 5S Ribosomal RNA 4l71 QV 77 3.9 RF00005 URS000041AF00_562 25128388 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal Structure of Frameshift Suppressor tRNA SufA6 Bound to Codon CCC-A on the Ribosome; P-site tRNA fMet 4l71 QY 14 3.9 25128388 32630 ucguucggngacga <<<<......>>>> (((........))) Crystal Structure of Frameshift Suppressor tRNA SufA6 Bound to Codon CCC-A on the Ribosome; messenger RNA 4l71 XV 77 3.9 RF00005 URS000041AF00_562 25128388 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal Structure of Frameshift Suppressor tRNA SufA6 Bound to Codon CCC-A on the Ribosome; P-site tRNA fMet 4l71 XY 14 3.9 25128388 32630 ucguucggngacga <<<<......>>>> (((........))) Crystal Structure of Frameshift Suppressor tRNA SufA6 Bound to Codon CCC-A on the Ribosome; messenger RNA 4lck B 75 3.2 RF00005 URS000080DE51_182710 23892783 0030533 0006412 182710 gaguaguucagugguagaacaccaccuugccaaggugggggucgcggguucgaaucccgucucgggcgaaagccc <<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>><<<<....>>>> (((..((((....[..)))).(((((.......))))).....(((((..]....))))))))((((....)))) Co-crystal structure of a T-box riboswitch stem I domain in complex with its cognate tRNA; tRNA-Gly 4lck C 102 3.2 RF00230 URS000080DF58_182710 23892783 0000049 182710 gggugcgaugagaagaagaguauuaaggauuuacuaugauuagcgacucuaggauagugaaagcuagaggauaguaaccuuaagaaggcacuucgagcaccc <<<<<<.....<<<<.......<<<<<<..<<<<<<<.........<<<<<<...........>>>>>>.>>>>>>>>>>>>>.......>>>>..>>>>>> ((((((.....((((.......((((((..(((((((......[..((((((..........])))))).))))))))))))).......))))..)))))) Co-crystal structure of a T-box riboswitch stem I domain in complex with its cognate tRNA; T-BOX RIBOSWITCH STEM I 4lck E 75 3.2 RF00005 URS000080DE51_182710 23892783 0030533 0006412 182710 gaguaguucagugguagaacaccaccuugccaaggugggggucgcggguucgaaucccgucucgggcgaaagccc <<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>><<<<....>>>> (((..((((....[..)))).(((((.......))))).....(((((..]....))))))))((((....)))) Co-crystal structure of a T-box riboswitch stem I domain in complex with its cognate tRNA; tRNA-Gly 4lck F 102 3.2 RF00230 URS000080DF58_182710 23892783 0000049 182710 gggugcgaugagaagaagaguauuaaggauuuacuaugauuagcgacucuaggauagugaaagcuagaggauaguaaccuuaagaaggcacuucgagcaccc <<<<<<.....<<<<.......<<<<<<..<<<<<<<.........<<<<<<...........>>>>>>.>>>>>>>>>>>>>.......>>>>..>>>>>> ((((((.....((((.......((.(((..(((((((......[..((((((..........])))))).)))))))))).)).......))))..)))))) Co-crystal structure of a T-box riboswitch stem I domain in complex with its cognate tRNA; T-BOX RIBOSWITCH STEM I 4lel QA 1500 3.9 RF00177,RF01959,RF01960 URS000080E226_300852 25128388 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggggucuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<...>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<......>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<..<.<<<<<<<........>>>>>>>>...>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(.((((((..(((((((....)))))))...((((....))))..)))))).)).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.((((((....((..(((.....))))).....)))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Crystal Structure of Frameshift Suppressor tRNA SufA6 Bound to Codon CCG-G on the Ribosome; 16S rRNA 4lel QV 77 3.9 RF00005 URS000041AF00_83333 25128388 0030533 0006412 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal Structure of Frameshift Suppressor tRNA SufA6 Bound to Codon CCG-G on the Ribosome; P-site tRNA fMet 4lel QY 14 3.9 25128388 32630 ucguucggngacga <<<<......>>>> (((........))) Crystal Structure of Frameshift Suppressor tRNA SufA6 Bound to Codon CCG-G on the Ribosome; messenger RNA 4lel RA 2882 3.9 RF02540,RF02541,RF00002 URS000080DFFB_300852 25128388 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<..>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[[)))...].((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...((((((((.....))))))))....[.((((((((.....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))).))))).))))....(((((((((.{.....)))))))))....].(((((}.[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...........)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((...((((((......)))).))...))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......(((((.(((..(((.........)))..))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........(((((..(((......((((((((....))))))))...)))............)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))..((((.....))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal Structure of Frameshift Suppressor tRNA SufA6 Bound to Codon CCG-G on the Ribosome; 23S rRNA 4lel RB 120 3.9 RF00001 URS00005F2F4B_300852 25128388 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> (((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).))))))))))) Crystal Structure of Frameshift Suppressor tRNA SufA6 Bound to Codon CCG-G on the Ribosome; 5S rRNA 4lel XA 1500 3.9 RF00177,RF01959,RF01960 URS000080E226_300852 25128388 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggggacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<...>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>....<<<<.<<<<<....>>>>>.>>>>...<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<.<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<......>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>..>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).(((.(...))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((((..(((((((....)))))))...((((....))))..))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Crystal Structure of Frameshift Suppressor tRNA SufA6 Bound to Codon CCG-G on the Ribosome; 16S rRNA 4lel XV 77 3.9 RF00005 URS000041AF00_83333 25128388 0030533 0006412 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal Structure of Frameshift Suppressor tRNA SufA6 Bound to Codon CCG-G on the Ribosome; P-site tRNA fMet 4lel XY 14 3.9 25128388 32630 ucguucggngacga <<<<......>>>> (((........))) Crystal Structure of Frameshift Suppressor tRNA SufA6 Bound to Codon CCG-G on the Ribosome; messenger RNA 4lel YA 2883 3.9 RF02540,RF02541,RF00002 URS000080DFFB_300852 25128388 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<..>>>>>>.>>....<<<<<.....<......>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<..>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[....>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<<..............<<<<<....<....>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>....>>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((..)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...((((((((.....))))))))....{.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).))))....(((((((((.[.....)))))))))....}.(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....()....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((...((((((......)))).))...))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((.(.......(((((.(((..(((.........)))..))).....(...((......)).).)))))...).)))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........(((((..(((......((((((((....))))))))...)))............)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.((((.....))))....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))...)))) Crystal Structure of Frameshift Suppressor tRNA SufA6 Bound to Codon CCG-G on the Ribosome; 23S rRNA 4lel YB 120 3.9 RF00001 URS00005F2F4B_300852 25128388 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> (((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).))))))))))) Crystal Structure of Frameshift Suppressor tRNA SufA6 Bound to Codon CCG-G on the Ribosome; 5S rRNA 4lfz QA 1500 3.92 RF00177,RF01959,RF01960 URS000080E226_300852 25128388 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggggucuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<...>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<......>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....(((...[.[[[...))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....)................)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(.((((((..(((((((....)))))))...((((....))))..)))))).)).((.(((...((((((......(((((((((....)))...(((......)))...)))))).....((((.(((((((.......(((.....)))......))))))).....(((((....)))))........)))).......).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Crystal Structure of Frameshift Suppressor tRNA SufA6 Bound to Codon CCC-U in the Absence of Paromomycin; 16S rRNA 4lfz QV 77 3.92 RF00005 URS000041AF00_83333 25128388 0030533 0006412 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal Structure of Frameshift Suppressor tRNA SufA6 Bound to Codon CCC-U in the Absence of Paromomycin; P-site tRNA fMet 4lfz QY 14 3.92 25128388 32630 ucguucggngacga <<<<......>>>> (((........))) Crystal Structure of Frameshift Suppressor tRNA SufA6 Bound to Codon CCC-U in the Absence of Paromomycin; messenger RNA 4lfz RA 2882 3.92 RF02540,RF02541,RF00002 URS000080DFFB_300852 25128388 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<..>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[....>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<<<<<<<<<..<<.......>>>..>>>>>>>..>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<<.....>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> .((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...(((.((((.....)))).)))....{.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).))))....(((((((((.[.....)))))))))....}.(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...........)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.....(((((..((...(((...((((((((...(((((........))).))...))))))))..)).)...))..))))).....))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......(((((.((...(((.........)))...)).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))(.((((((.....)))))).)....))))))..(((((...(((......(((((.(((....))))))))...)))..)))))........))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..))).....(((....))).......)))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........(((((..(((......((((((((....))))))))...)))............)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.((((.....))))....(((((((((.......)))))....((((((((.((.....(((((....)))))....))..))))).)))...))))...))). Crystal Structure of Frameshift Suppressor tRNA SufA6 Bound to Codon CCC-U in the Absence of Paromomycin; 23S rRNA 4lfz RB 120 3.92 RF00001 URS00005F2F4B_300852 25128388 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> (((((((.(((....((((((.(....(.(((((...(.....)...))))..).)...).)))).))(((.......((.(((((....))))).)).......))).))).))))))) Crystal Structure of Frameshift Suppressor tRNA SufA6 Bound to Codon CCC-U in the Absence of Paromomycin; 5S rRNA 4lfz XA 1500 3.92 RF00177,RF01959,RF01960 URS000080E226_300852 25128388 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggggacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<...>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<........<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<......>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>......>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((..(...).))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((.(...(((((((((......((........))..........(((((((..(...((((((((..(((((((....)))))))...((((....))))..))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((.......(((.....)))......))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))..(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..).))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Crystal Structure of Frameshift Suppressor tRNA SufA6 Bound to Codon CCC-U in the Absence of Paromomycin; 16S rRNA 4lfz XV 77 3.92 RF00005 URS000041AF00_83333 25128388 0030533 0006412 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal Structure of Frameshift Suppressor tRNA SufA6 Bound to Codon CCC-U in the Absence of Paromomycin; P-site tRNA fMet 4lfz XY 14 3.92 25128388 32630 ucguucggngacga <<<<......>>>> (((........))) Crystal Structure of Frameshift Suppressor tRNA SufA6 Bound to Codon CCC-U in the Absence of Paromomycin; messenger RNA 4lfz YA 2883 3.92 RF02540,RF02541,RF00002 URS000080DFFB_300852 25128388 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<..>>>>>>.>>....<<<<<.....<......>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<..>...>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[....>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<<<<<<<<...<<.......>>...>>>>>>>..>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> ((.......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((..)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((......(...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)..)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...........)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((...((((((......)))).))...))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......(((((..((..(((.........)))..))......(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).))))..((((....))))...))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........(...........(((((.......))))).....)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........(((((...((......((((((((....))))))))...)).............)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((]..[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].......(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(..(((.....))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...).)) Crystal Structure of Frameshift Suppressor tRNA SufA6 Bound to Codon CCC-U in the Absence of Paromomycin; 23S rRNA 4lfz YB 120 3.92 RF00001 URS00005F2F4B_300852 25128388 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......)))..)))))))))) Crystal Structure of Frameshift Suppressor tRNA SufA6 Bound to Codon CCC-U in the Absence of Paromomycin; 5S rRNA 4lg2 J 12 2.7 URS000080E156_32630 23824825 32630 cuagacgucuag ............ ............ Crystal structure of Reston Ebola virus VP35 RNA binding domain bound to 12-bp dsRNA; dsRNA 4lg2 I 12 2.7 URS000080E156_32630 23824825 32630 cuagacgucuag ............ ............ Crystal structure of Reston Ebola virus VP35 RNA binding domain bound to 12-bp dsRNA; dsRNA 4lnt QA 1500 2.94 RF00177,RF01959,RF01960 URS000080E226_300852 25128388 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggggucuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<...>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<......>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(.((((((..(((((((....)))))))...((((....))))..)))))).)).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((.......(((.....)))......))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Crystal Structure of tRNA Proline (CGG) Bound to Codon CCC-U on the Ribosome; 16S rRNA 4lnt QV 77 2.94 RF00005 URS000041AF00_83333 25128388 0030533 0006412 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal Structure of tRNA Proline (CGG) Bound to Codon CCC-U on the Ribosome; P-site tRNA fMet 4lnt QY 15 2.94 25128388 32630 cucguucggnacgag <<<<<.....>>>>> ((((.......)))) Crystal Structure of tRNA Proline (CGG) Bound to Codon CCC-U on the Ribosome; messenger RNA 4lnt RA 2882 2.94 RF02540,RF02541,RF00002 URS000080DFFB_300852 25128388 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>....<<<<<.....<......>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<..>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[[)))...].((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....(())...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((...((((((......)))).))...))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......(((((.((...(((.........)))...)).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........(((((..(((......((((((((....))))))))...)))............)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.((((.....))))....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))...)))) Crystal Structure of tRNA Proline (CGG) Bound to Codon CCC-U on the Ribosome; 23S rRNA 4lnt RB 120 2.94 RF00001 URS00005F2F4B_300852 25128388 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> (((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).))))))))))) Crystal Structure of tRNA Proline (CGG) Bound to Codon CCC-U on the Ribosome; 5S rRNA 4lnt XA 1500 2.94 RF00177,RF01959,RF01960 URS000080E226_300852 25128388 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggggacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<...>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<......>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).(((.(...))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((((..(((((((....)))))))...((((....))))..))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...(...(((.....))).)....)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Crystal Structure of tRNA Proline (CGG) Bound to Codon CCC-U on the Ribosome; 16S rRNA 4lnt XV 77 2.94 RF00005 URS000041AF00_83333 25128388 0030533 0006412 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal Structure of tRNA Proline (CGG) Bound to Codon CCC-U on the Ribosome; P-site tRNA fMet 4lnt XY 15 2.94 25128388 32630 cucguucggnacgag <<<<<.....>>>>> ((((.......)))) Crystal Structure of tRNA Proline (CGG) Bound to Codon CCC-U on the Ribosome; messenger RNA 4lnt YA 2883 2.94 RF02540,RF02541,RF00002 URS000080DFFB_300852 25128388 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<..>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<..>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<<.....>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((..)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....(())...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((...((((((......)))).))...)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......(((((.(((..(((.........)))..))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........(((((..(((......((((((((....))))))))...)))............)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.((((.....))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal Structure of tRNA Proline (CGG) Bound to Codon CCC-U on the Ribosome; 23S rRNA 4lnt YB 120 2.94 RF00001 URS00005F2F4B_300852 25128388 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> (((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).))))))))))) Crystal Structure of tRNA Proline (CGG) Bound to Codon CCC-U on the Ribosome; 5S rRNA 4lsk QA 1500 3.48001 RF00177,RF01959,RF01960 URS000080E226_300852 25128388 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggggucuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<...>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<......>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(.((((((..(((((((....)))))))...((((....))))..)))))).)).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Crystal Structure of tRNA Proline (CGG) Bound to Codon CCG-G on the Ribosome; 16S rRNA 4lsk QV 77 3.48001 RF00005 URS000041AF00_83333 25128388 0030533 0006412 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal Structure of tRNA Proline (CGG) Bound to Codon CCG-G on the Ribosome; P-site tRNA fMet 4lsk QY 15 3.48001 25128388 32630 cucguucggnacgag <<<<<.....>>>>> ((((.......)))) Crystal Structure of tRNA Proline (CGG) Bound to Codon CCG-G on the Ribosome; messenger RNA 4lsk RA 2882 3.48001 RF02540,RF02541,RF00002 URS000080DFFB_300852 25128388 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<..>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<<........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>.>>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<..<<<<<<<...<<.......>>...>>>>>>>...>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[[)))...].((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....()....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((....((((........))).)....))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......(((((.(((..(((.........)))..))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..((....((...(((((....)))))...))....)))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........(((((..(((......((((((((....))))))))...)))............)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.((((.....))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal Structure of tRNA Proline (CGG) Bound to Codon CCG-G on the Ribosome; 23S rRNA 4lsk RB 120 3.48001 RF00001 URS00005F2F4B_300852 25128388 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> (((((((((((....((((((((....(.(((((...(.....)...))))..).)...)))))).))(((.......((.(((((....))))).)).......))).))))))))))) Crystal Structure of tRNA Proline (CGG) Bound to Codon CCG-G on the Ribosome; 5S rRNA 4lsk XA 1500 3.48001 RF00177,RF01959,RF01960 URS000080E226_300852 25128388 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggggacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<...>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<......>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).(((.(...))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((.(((((...))))).))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((((..(((((((....)))))))...((((....))))..))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((.......(((.....)))......))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Crystal Structure of tRNA Proline (CGG) Bound to Codon CCG-G on the Ribosome; 16S rRNA 4lsk XV 77 3.48001 RF00005 URS000041AF00_83333 25128388 0030533 0006412 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal Structure of tRNA Proline (CGG) Bound to Codon CCG-G on the Ribosome; P-site tRNA fMet 4lsk XY 15 3.48001 25128388 32630 cucguucggnacgag <<<<<.....>>>>> ((((.......)))) Crystal Structure of tRNA Proline (CGG) Bound to Codon CCG-G on the Ribosome; messenger RNA 4lsk YA 2883 3.48001 RF02540,RF02541,RF00002 URS000080DFFB_300852 25128388 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<..>>>>>>.>>....<<<<<.....<......>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<..>...>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<<........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>.>>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<<..<<.......>>>..>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<<.....>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[[)))...].((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((..)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....(())...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((...((((((......)))).))...))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......(((((.(((..(((.........)))..))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........(((((..(((......((((((((....))))))))...)))............)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.((((.....))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal Structure of tRNA Proline (CGG) Bound to Codon CCG-G on the Ribosome; 23S rRNA 4lsk YB 120 3.48001 RF00001 URS00005F2F4B_300852 25128388 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> (((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).))))))))))) Crystal Structure of tRNA Proline (CGG) Bound to Codon CCG-G on the Ribosome; 5S rRNA 4lt8 QA 1500 3.14 RF00177,RF01959,RF01960 URS000080E226_300852 25128388 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggggucuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<...>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<......>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((......(.((((((..(((((((....)))))))...((((....))))..)))))).)..((.(((...((((((......(((((((((....)))...(((......)))...)))))).....((((.((((.((...(...(((.....))).)....)).)))).....(((((....)))))........)))).......).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Crystal Structure of tRNA Proline (CGG) Bound to Codon CCC-G on the Ribosome; 16S rRNA 4lt8 QV 77 3.14 RF00005 URS000041AF00_83333 25128388 0030533 0006412 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal Structure of tRNA Proline (CGG) Bound to Codon CCC-G on the Ribosome; P-site tRNA fMet 4lt8 QY 15 3.14 25128388 32630 cucguucggnacgag <<<<<.....>>>>> ((((.......)))) Crystal Structure of tRNA Proline (CGG) Bound to Codon CCC-G on the Ribosome; messenger RNA 4lt8 RA 2882 3.14 RF02540,RF02541,RF00002 URS000080DFFB_300852 25128388 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<..>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<<.....>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[[)))...].((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....(())...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((....(((((......)))).)....))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......(((((.(((..(((.........)))..))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........(((((..(((......((((((((....))))))))...)))............)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.((((.....))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal Structure of tRNA Proline (CGG) Bound to Codon CCC-G on the Ribosome; 23S rRNA 4lt8 RB 120 3.14 RF00001 URS00005F2F4B_300852 25128388 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> (((((((((((....((((((((....(.(((((...(.....)...))))..).)...)))))).))(((.......((.(((((....))))).)).......))).))))))))))) Crystal Structure of tRNA Proline (CGG) Bound to Codon CCC-G on the Ribosome; 5S rRNA 4lt8 XA 1500 3.14 RF00177,RF01959,RF01960 URS000080E226_300852 25128388 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggggacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<...>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<......>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((((..(((((((....)))))))...((((....))))..))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...(...(((.....))).)....)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Crystal Structure of tRNA Proline (CGG) Bound to Codon CCC-G on the Ribosome; 16S rRNA 4lt8 XV 77 3.14 RF00005 URS000041AF00_83333 25128388 0030533 0006412 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal Structure of tRNA Proline (CGG) Bound to Codon CCC-G on the Ribosome; P-site tRNA fMet 4lt8 XY 15 3.14 25128388 32630 cucguucggnacgag <<<<<.....>>>>> ((((.......)))) Crystal Structure of tRNA Proline (CGG) Bound to Codon CCC-G on the Ribosome; messenger RNA 4lt8 YA 2883 3.14 RF02540,RF02541,RF00002 URS000080DFFB_300852 25128388 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu 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(((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((..)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....(())...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((...((((((......)))).))...))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......(((((.(((..(((.........)))..))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........(((((..(((......((((((((....))))))))...)))............)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.((((.....))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal Structure of tRNA Proline (CGG) Bound to Codon CCC-G on the Ribosome; 23S rRNA 4lt8 YB 120 3.14 RF00001 URS00005F2F4B_300852 25128388 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> (((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).))))))))))) Crystal Structure of tRNA Proline (CGG) Bound to Codon CCC-G on the Ribosome; 5S rRNA 4m2z C 27 2.85 URS000080DEBF_32630 24274754 32630 aaggucauucgcaagaguggccuugcg <<<<<<<<<<....>>>>>>>>>>... ((((((((((....))))))))))... Crystal structure of RNASE III complexed with double-stranded RNA and CMP (TYPE II CLEAVAGE); RNA10 4m2z D 27 2.85 URS000080DEBF_32630 24274754 32630 aaggucauucgcaagaguggccuugcg <<<<<<<<<<....>>>>>>>>>>... ((((((((((....))))))))))... Crystal structure of RNASE III complexed with double-stranded RNA and CMP (TYPE II CLEAVAGE); RNA10 4m30 C 27 2.501 URS000080DE8F_32630 24274754 32630 aaggucauucgcaagaguggccuuuau <<<<<<<<<<....>>>>>>>>>>... ((((((((((....))))))))))... Crystal structure of RNASE III complexed with double-stranded RNA AND AMP (TYPE II CLEAVAGE); RNA12 4m30 D 27 2.501 URS000080DE8F_32630 24274754 32630 aaggucauucgcaagaguggccuuuau <<<<<<<<<<....>>>>>>>>>>... ((((((((((....))))))))))... Crystal structure of RNASE III complexed with double-stranded RNA AND AMP (TYPE II CLEAVAGE); RNA12 4mce A 10 2.205 URS000080DE97_9606 25377354 9606 caguggucuu .......... .......... Crystal structure of the Gas5 GRE Mimic; Gas5 GREM Fwd 4mce B 10 2.205 URS000080DF2A_9606 25377354 9606 aagacugccu .......... .......... Crystal structure of the Gas5 GRE Mimic; Gas5 GREM Rev 4mce C 10 2.205 URS000080DE97_9606 25377354 9606 caguggucuu .......... .......... Crystal structure of the Gas5 GRE Mimic; Gas5 GREM Fwd 4mce D 11 2.205 URS000080DF2A_9606 25377354 9606 aagacugccug ........... ........... Crystal structure of the Gas5 GRE Mimic; Gas5 GREM Rev 4mcf D 11 1.899 URS000080DF2A_9606 25377354 9606 aagacugccug ........... ........... Crystal structure of the Gas5 GRE Mimic; Gas5 GREM Rev 4mcf B 11 1.899 URS000080DF2A_9606 25377354 9606 aagacugccug ........... ........... Crystal structure of the Gas5 GRE Mimic; Gas5 GREM Rev 4mcf E 10 1.899 URS000080DE97_9606 25377354 9606 caguggucuu .......... .......... Crystal structure of the Gas5 GRE Mimic; Gas5 GREM Fwd 4mcf F 10 1.899 URS000080DF2A_9606 25377354 9606 aagacugccu .......... .......... Crystal structure of the Gas5 GRE Mimic; Gas5 GREM Rev 4mcf G 10 1.899 URS000080DE97_9606 25377354 9606 caguggucuu .......... .......... Crystal structure of the Gas5 GRE Mimic; Gas5 GREM Fwd 4mcf H 10 1.899 URS000080DF2A_9606 25377354 9606 aagacugccu .......... .......... Crystal structure of the Gas5 GRE Mimic; Gas5 GREM Rev 4meg A 18 3.1 URS000080E125_32630 24096303 32630 agcgccuggacuuaaagc .................. .................. In vitro evolved glmS ribozyme triple mutant, magnesium ion complex; glmS triple mutant ribozyme 4meg B 121 3.1 RF00234 URS000080E1A0_119072 24096303 0003824 0010468 119072 cuuuaaguugacgagggcaggguuaaacgagacaucggcgagugcccugcggucuuccugcgaccguuagaggacugguaaaaccacaggcgacuguggcauagagcaguccgggcaggaa ...........((....<<<<<<....))..............>>>>>>(((((.<<<<<<))))).....<<<<<<......<<<<<<....>>>>>>.......>>>>>>..>>>>>>. ...........[[....((((((....]]..............))))))[[[[[.((((((]]]]].....((((((......((((((....)))))).......))))))..)))))). In vitro evolved glmS ribozyme triple mutant, magnesium ion complex; (121-MER) ribozyme 4meh A 22 3.12 URS000080E125_32630 24096303 32630 agcgccuggacuuaaagccauu ...................... ...................... In vitro evolved glmS ribozyme triple mutant, calcium ion complex; glmS triple mutant ribozyme 4meh B 122 3.12 RF00234 URS000080E1A0_119072 24096303 0003824 0010468 119072 ggcuuuaaguugacgagggcaggguuaaacgagacaucggcgagugcccugcggucuccugcgaccguuagaggacugguaaaaccacaggcgacuguggcauagagcaguccgggcaggaa .............((....<<<<<<....))..............>>>>>>(((((<<<<<<))))).....<<<<<<......<<<<<<....>>>>>>.......>>>>>>..>>>>>>. .............[[....((((((....]]..............))))))(((((.[[[[[))))).....((((((......((((((....)))))).......))))))..]]]]].. In vitro evolved glmS ribozyme triple mutant, calcium ion complex; (122-MER) ribozyme 4mgn A 86 3.2 URS000080E2B0_1462 24095061 1462 ngaaucaauaguaguuaacccucucuuccgaagcgagccgggggcggugggagcccggugaagacgguuaaugaaacggcaguucc <<<<<........<<<<<<<...<<<<<........<<<<<<...........>>>>>>>>>>>.>>>>>>>.........>>>>> (((((.........((((((...(((((.....[..((((((..........]))))))))))).))))))..........))))) Co-crystal structure of the G. kaustophilus glyQS T box riboswitch Stem I in complex with tRNA; glyQS T box riboswitch 4mgn B 72 3.2 RF00005 URS000015A751_1462 24095061 0030533 0006412 1462 ncggaaguaguucagugguagaacaccaccuugccaaggugggggucgcggguucgagucccgucuuccgcu <<<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>. (((((((..((((....[..)))).(((((.......))))).....(((((..]....)))))))))))). Co-crystal structure of the G. kaustophilus glyQS T box riboswitch Stem I in complex with tRNA; tRNA-glycine 4mgn C 86 3.2 URS000080E2B0_1462 24095061 1462 ngaaucaauaguaguuaacccucucuuccgaagcgagccgggggcggugggagcccggugaagacgguuaaugaaacggcaguucc <<<<<........<<<<<<<...<<<<<........<<<<<<...........>>>>>>>>>>>.>>>>>>>.........>>>>> ((((.........(((((((...(((((.....[..((((((..........]))))))))))).)))))))..........)))) Co-crystal structure of the G. kaustophilus glyQS T box riboswitch Stem I in complex with tRNA; glyQS T box riboswitch 4mgn D 73 3.2 RF00005 URS000015A751_1462 24095061 0030533 0006412 1462 ncggaaguaguucagugguagaacaccaccuugccaaggugggggucgcggguucgagucccgucuuccgcuc <<<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.. (((((((..((((....[..)))).(((((.......))))).....(((((..]....)))))))))))).. Co-crystal structure of the G. kaustophilus glyQS T box riboswitch Stem I in complex with tRNA; tRNA-glycine 4ms9 A 10 1.32 URS000080E19F_32630 24516151 32630 ccggcgccgg .......... .......... Native RNA-10mer Structure: ccggcgccgg; Native RNA duplex 10mer 4msb A 10 1.55 URS000080E19F_32630 24516151 32630 ccggcgccgg .......... .......... RNA 10mer duplex with two 2'-5'-linkages; RNA 10mer duplex with two 2'-5'-linkages 4msb B 10 1.55 URS000080E19F_32630 24516151 32630 ccggcgccgg .......... .......... RNA 10mer duplex with two 2'-5'-linkages; RNA 10mer duplex with two 2'-5'-linkages 4msb C 10 1.55 URS000080E19F_32630 24516151 32630 ccggcgccgg .......... .......... RNA 10mer duplex with two 2'-5'-linkages; RNA 10mer duplex with two 2'-5'-linkages 4msb D 10 1.55 URS000080E19F_32630 24516151 32630 ccggcgccgg .......... .......... RNA 10mer duplex with two 2'-5'-linkages; RNA 10mer duplex with two 2'-5'-linkages 4msb E 10 1.55 URS000080E19F_32630 24516151 32630 ccggcgccgg .......... .......... RNA 10mer duplex with two 2'-5'-linkages; RNA 10mer duplex with two 2'-5'-linkages 4msb F 10 1.55 URS000080E19F_32630 24516151 32630 ccggcgccgg .......... .......... RNA 10mer duplex with two 2'-5'-linkages; RNA 10mer duplex with two 2'-5'-linkages 4msr A 10 1.2 URS000080E19F_32630 24516151 32630 ccggcgccgg .......... .......... RNA 10mer duplex with six 2'-5'-linkages; RNA 10mer duplex with six 2'-5'-linkages 4msr B 10 1.2 URS000080E19F_32630 24516151 32630 ccggcgccgg .......... .......... RNA 10mer duplex with six 2'-5'-linkages; RNA 10mer duplex with six 2'-5'-linkages 4nfo A 16 1.96 URS000080DF15_32630 24896732 32630 gcagacuuaagucugc ................ ................ Crystal Structure Analysis of the 16mer GCAGACUUAAGUCUGC; GCAGACUUAAGUCUGC 4nfo B 16 1.96 URS000080DF15_32630 24896732 32630 gcagacuuaagucugc ................ ................ Crystal Structure Analysis of the 16mer GCAGACUUAAGUCUGC; GCAGACUUAAGUCUGC 4nfo C 16 1.96 URS000080DF15_32630 24896732 32630 gcagacuuaagucugc ................ ................ Crystal Structure Analysis of the 16mer GCAGACUUAAGUCUGC; GCAGACUUAAGUCUGC 4nfp A 16 1.85 URS000080DF15_32630 24896732 32630 gcagncuuaagucugc ................ ................ Crystal Structure Analysis of the 16mer GCAGNCUUAAGUCUGC containing 8-aza-7-deaza-7-ethynyl Adenosine; GCAG(A7E)CUUAAGUCUGC 4nfp B 16 1.85 URS000080DF15_32630 24896732 32630 gcagncuuaagucugc ................ ................ Crystal Structure Analysis of the 16mer GCAGNCUUAAGUCUGC containing 8-aza-7-deaza-7-ethynyl Adenosine; GCAG(A7E)CUUAAGUCUGC 4nfp C 16 1.85 URS000080DF15_32630 24896732 32630 gcagncuuaagucugc ................ ................ Crystal Structure Analysis of the 16mer GCAGNCUUAAGUCUGC containing 8-aza-7-deaza-7-ethynyl Adenosine; GCAG(A7E)CUUAAGUCUGC 4nfq A 16 1.7 URS000080DF15_32630 24896732 32630 gcagncuuaagucugc ................ ................ Crystal Structure Analysis of the 16mer GCAGNCUUAAGUCUGC containing 7-triazolyl-8-aza-7-deazaadenosine; GCAG(7AT)CUUAAGUCUGC 4nfq B 16 1.7 URS000080DF15_32630 24896732 32630 gcagncuuaagucugc ................ ................ Crystal Structure Analysis of the 16mer GCAGNCUUAAGUCUGC containing 7-triazolyl-8-aza-7-deazaadenosine; GCAG(7AT)CUUAAGUCUGC 4nfq C 16 1.7 URS000080DF15_32630 24896732 32630 gcagncuuaagucugc ................ ................ Crystal Structure Analysis of the 16mer GCAGNCUUAAGUCUGC containing 7-triazolyl-8-aza-7-deazaadenosine; GCAG(7AT)CUUAAGUCUGC 4ngb B 12 2.25 URS000080E150_32630 24486018 32630 gcgaauucgcuu ............ ............ Structure of human Dicer Platform-PAZ-Connector Helix cassette in complex with 12-mer siRNA having UU-3' ends (2.25 Angstrom resolution); 5'-R(*GP*CP*GP*AP*AP*UP*UP*CP*GP*CP*UP*U)-3' 4ngc B 12 2.104 URS000080DE7A_32630 24486018 32630 gcgaauucgcua ............ ............ Structure of human Dicer Platform-PAZ-Connector Helix cassette in complex with 12-mer siRNA having UA-3' ends (2.1 Angstrom resolution); 5'-R(*GP*CP*GP*AP*AP*UP*UP*CP*GP*CP*UP*A)-3' 4ngd B 12 1.958 URS000080E150_32630 24486018 32630 gcgaauucgcuu ............ ............ Structure of human Dicer Platform-PAZ-Connector Helix cassette in complex with 12-mer siRNA having 5'-p and UU-3' ends (1.95 Angstrom resolution); 5'-R(P*GP*CP*GP*AP*AP*UP*UP*CP*GP*CP*UP*U)-3' 4ngf E 17 3.101 URS000080DDF2_32630 24486018 32630 ucgaagguccuucguuu ................. ................. Structure of human Dicer Platform-PAZ-Connector Helix cassette in complex with 17-mer siRNA having 5'-p and UU-3' ends (3.1 Angstrom resolution); 5'-R(P*UP*CP*GP*AP*AP*GP*GP*UP*CP*CP*UP*UP*CP*GP*UP*UP*U)-3' 4ngf F 17 3.101 URS000080DDF2_32630 24486018 32630 ucgaagguccuucguuu ................. ................. Structure of human Dicer Platform-PAZ-Connector Helix cassette in complex with 17-mer siRNA having 5'-p and UU-3' ends (3.1 Angstrom resolution); 5'-R(P*UP*CP*GP*AP*AP*GP*GP*UP*CP*CP*UP*UP*CP*GP*UP*UP*U)-3' 4ngf G 17 3.101 URS000080DDF2_32630 24486018 32630 ucgaagguccuucguuu ................. ................. Structure of human Dicer Platform-PAZ-Connector Helix cassette in complex with 17-mer siRNA having 5'-p and UU-3' ends (3.1 Angstrom resolution); 5'-R(P*UP*CP*GP*AP*AP*GP*GP*UP*CP*CP*UP*UP*CP*GP*UP*UP*U)-3' 4ngf H 17 3.101 URS000080DDF2_32630 24486018 32630 ucgaagguccuucguuu ................. ................. Structure of human Dicer Platform-PAZ-Connector Helix cassette in complex with 17-mer siRNA having 5'-p and UU-3' ends (3.1 Angstrom resolution); 5'-R(P*UP*CP*GP*AP*AP*GP*GP*UP*CP*CP*UP*UP*CP*GP*UP*UP*U)-3' 4ngg B 13 2.6 URS000080E1FD_32630 24486018 32630 agcgaauucgcuu ............. ............. Structure of human Dicer Platform-PAZ-Connector Helix cassette in complex with 13-mer siRNA having 5'-A and UU-3' ends (2.6 Angstrom resolution); 5'-R(*AP*GP*CP*GP*AP*AP*UP*UP*CP*GP*CP*UP*U)-3' 4nh3 B 13 2.616 URS000080DED3_32630 24486018 32630 ugcgaauucgcuu ............. ............. Structure of human Dicer Platform-PAZ-Connector Helix cassette in complex with 13-mer siRNA having 5'-pU and UU-3' ends (2.6 Angstrom resolution); 5'-R(P*UP*GP*CP*GP*AP*AP*UP*UP*CP*GP*CP*UP*U)-3' 4nh5 B 14 2.55 URS000080DE71_32630 24486018 32630 uugcgaauucgcuu .............. .............. Structure of human Dicer Platform-PAZ-Connector Helix cassette in complex with 14-mer siRNA having 5'-pUU and UU-3' ends (2.55 Angstrom resolution); 5'-R(P*UP*UP*GP*CP*GP*AP*AP*UP*UP*CP*GP*CP*UP*U)-3' 4nh6 B 15 2.551 URS000080DDE0_32630 24486018 32630 uuugcgaauucgcuu ............... ............... Structure of human Dicer Platform-PAZ-Connector Helix cassette in complex with 15-mer siRNA having 5'-pUUU and UU-3' ends (2.55 Angstrom resolution); 5'-R(P*UP*UP*UP*GP*CP*GP*AP*AP*UP*UP*CP*GP*CP*UP*U)-3' 4nha B 16 3.401 URS000080E081_32630 24486018 32630 gcguuggccaacgcuu ................ ................ Structure of human Dicer Platform-PAZ-Connector Helix cassette in complex with 16-mer siRNA having 5'-p and UU-3' ends (3.4 Angstrom resolution); 5'-R(P*GP*CP*GP*UP*UP*GP*GP*CP*CP*AP*AP*CP*GP*CP*UP*U)-3' 4nia P 10 1.82 URS000080DEB3_12881 25195746,9514737,8510153,8421525,1303744,2585487 12881 aaaaaaaaaa .......... .......... Satellite Tobacco Mosaic Virus Refined at room temperature to 1.8 A Resolution using NCS Restraints; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 4nia e 10 1.82 URS00002C5188_12881 25195746,9514737,8510153,8421525,1303744,2585487 12881 uuuuuuuuuu .......... .......... Satellite Tobacco Mosaic Virus Refined at room temperature to 1.8 A Resolution using NCS Restraints; RNA (5'-R(P*UP*UP*UP*UP*UP*UP*UP*UP*UP*U)-3') 4nia Q 10 1.82 URS000080DEB3_12881 25195746,9514737,8510153,8421525,1303744,2585487 12881 aaaaaaaaaa .......... .......... Satellite Tobacco Mosaic Virus Refined at room temperature to 1.8 A Resolution using NCS Restraints; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 4nia f 10 1.82 URS00002C5188_12881 25195746,9514737,8510153,8421525,1303744,2585487 12881 uuuuuuuuuu .......... .......... Satellite Tobacco Mosaic Virus Refined at room temperature to 1.8 A Resolution using NCS Restraints; RNA (5'-R(P*UP*UP*UP*UP*UP*UP*UP*UP*UP*U)-3') 4nia R 10 1.82 URS000080DEB3_12881 25195746,9514737,8510153,8421525,1303744,2585487 12881 aaaaaaaaaa .......... .......... Satellite Tobacco Mosaic Virus Refined at room temperature to 1.8 A Resolution using NCS Restraints; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 4nia g 10 1.82 URS00002C5188_12881 25195746,9514737,8510153,8421525,1303744,2585487 12881 uuuuuuuuuu .......... .......... Satellite Tobacco Mosaic Virus Refined at room temperature to 1.8 A Resolution using NCS Restraints; RNA (5'-R(P*UP*UP*UP*UP*UP*UP*UP*UP*UP*U)-3') 4nia S 10 1.82 URS000080DEB3_12881 25195746,9514737,8510153,8421525,1303744,2585487 12881 aaaaaaaaaa .......... .......... Satellite Tobacco Mosaic Virus Refined at room temperature to 1.8 A Resolution using NCS Restraints; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 4nia h 10 1.82 URS00002C5188_12881 25195746,9514737,8510153,8421525,1303744,2585487 12881 uuuuuuuuuu .......... .......... Satellite Tobacco Mosaic Virus Refined at room temperature to 1.8 A Resolution using NCS Restraints; RNA (5'-R(P*UP*UP*UP*UP*UP*UP*UP*UP*UP*U)-3') 4nia T 10 1.82 URS000080DEB3_12881 25195746,9514737,8510153,8421525,1303744,2585487 12881 aaaaaaaaaa .......... .......... Satellite Tobacco Mosaic Virus Refined at room temperature to 1.8 A Resolution using NCS Restraints; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 4nia i 10 1.82 URS00002C5188_12881 25195746,9514737,8510153,8421525,1303744,2585487 12881 uuuuuuuuuu .......... .......... Satellite Tobacco Mosaic Virus Refined at room temperature to 1.8 A Resolution using NCS Restraints; RNA (5'-R(P*UP*UP*UP*UP*UP*UP*UP*UP*UP*U)-3') 4nia U 10 1.82 URS000080DEB3_12881 25195746,9514737,8510153,8421525,1303744,2585487 12881 aaaaaaaaaa .......... .......... Satellite Tobacco Mosaic Virus Refined at room temperature to 1.8 A Resolution using NCS Restraints; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 4nia j 10 1.82 URS00002C5188_12881 25195746,9514737,8510153,8421525,1303744,2585487 12881 uuuuuuuuuu .......... .......... Satellite Tobacco Mosaic Virus Refined at room temperature to 1.8 A Resolution using NCS Restraints; RNA (5'-R(P*UP*UP*UP*UP*UP*UP*UP*UP*UP*U)-3') 4nia V 10 1.82 URS000080DEB3_12881 25195746,9514737,8510153,8421525,1303744,2585487 12881 aaaaaaaaaa .......... .......... Satellite Tobacco Mosaic Virus Refined at room temperature to 1.8 A Resolution using NCS Restraints; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 4nia k 10 1.82 URS00002C5188_12881 25195746,9514737,8510153,8421525,1303744,2585487 12881 uuuuuuuuuu .......... .......... Satellite Tobacco Mosaic Virus Refined at room temperature to 1.8 A Resolution using NCS Restraints; RNA (5'-R(P*UP*UP*UP*UP*UP*UP*UP*UP*UP*U)-3') 4nia W 10 1.82 URS000080DEB3_12881 25195746,9514737,8510153,8421525,1303744,2585487 12881 aaaaaaaaaa .......... .......... Satellite Tobacco Mosaic Virus Refined at room temperature to 1.8 A Resolution using NCS Restraints; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 4nia l 10 1.82 URS00002C5188_12881 25195746,9514737,8510153,8421525,1303744,2585487 12881 uuuuuuuuuu .......... .......... Satellite Tobacco Mosaic Virus Refined at room temperature to 1.8 A Resolution using NCS Restraints; RNA (5'-R(P*UP*UP*UP*UP*UP*UP*UP*UP*UP*U)-3') 4nia X 10 1.82 URS000080DEB3_12881 25195746,9514737,8510153,8421525,1303744,2585487 12881 aaaaaaaaaa .......... .......... Satellite Tobacco Mosaic Virus Refined at room temperature to 1.8 A Resolution using NCS Restraints; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 4nia m 10 1.82 URS00002C5188_12881 25195746,9514737,8510153,8421525,1303744,2585487 12881 uuuuuuuuuu .......... .......... Satellite Tobacco Mosaic Virus Refined at room temperature to 1.8 A Resolution using NCS Restraints; RNA (5'-R(P*UP*UP*UP*UP*UP*UP*UP*UP*UP*U)-3') 4nia Y 10 1.82 URS000080DEB3_12881 25195746,9514737,8510153,8421525,1303744,2585487 12881 aaaaaaaaaa .......... .......... Satellite Tobacco Mosaic Virus Refined at room temperature to 1.8 A Resolution using NCS Restraints; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 4nia n 10 1.82 URS00002C5188_12881 25195746,9514737,8510153,8421525,1303744,2585487 12881 uuuuuuuuuu .......... .......... Satellite Tobacco Mosaic Virus Refined at room temperature to 1.8 A Resolution using NCS Restraints; RNA (5'-R(P*UP*UP*UP*UP*UP*UP*UP*UP*UP*U)-3') 4nia Z 10 1.82 URS000080DEB3_12881 25195746,9514737,8510153,8421525,1303744,2585487 12881 aaaaaaaaaa .......... .......... Satellite Tobacco Mosaic Virus Refined at room temperature to 1.8 A Resolution using NCS Restraints; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 4nia o 10 1.82 URS00002C5188_12881 25195746,9514737,8510153,8421525,1303744,2585487 12881 uuuuuuuuuu .......... .......... Satellite Tobacco Mosaic Virus Refined at room temperature to 1.8 A Resolution using NCS Restraints; RNA (5'-R(P*UP*UP*UP*UP*UP*UP*UP*UP*UP*U)-3') 4nia a 10 1.82 URS000080DEB3_12881 25195746,9514737,8510153,8421525,1303744,2585487 12881 aaaaaaaaaa .......... .......... Satellite Tobacco Mosaic Virus Refined at room temperature to 1.8 A Resolution using NCS Restraints; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 4nia p 10 1.82 URS00002C5188_12881 25195746,9514737,8510153,8421525,1303744,2585487 12881 uuuuuuuuuu .......... .......... Satellite Tobacco Mosaic Virus Refined at room temperature to 1.8 A Resolution using NCS Restraints; RNA (5'-R(P*UP*UP*UP*UP*UP*UP*UP*UP*UP*U)-3') 4nia b 10 1.82 URS000080DEB3_12881 25195746,9514737,8510153,8421525,1303744,2585487 12881 aaaaaaaaaa .......... .......... Satellite Tobacco Mosaic Virus Refined at room temperature to 1.8 A Resolution using NCS Restraints; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 4nia q 10 1.82 URS00002C5188_12881 25195746,9514737,8510153,8421525,1303744,2585487 12881 uuuuuuuuuu .......... .......... Satellite Tobacco Mosaic Virus Refined at room temperature to 1.8 A Resolution using NCS Restraints; RNA (5'-R(P*UP*UP*UP*UP*UP*UP*UP*UP*UP*U)-3') 4nia c 10 1.82 URS000080DEB3_12881 25195746,9514737,8510153,8421525,1303744,2585487 12881 aaaaaaaaaa .......... .......... Satellite Tobacco Mosaic Virus Refined at room temperature to 1.8 A Resolution using NCS Restraints; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 4nia r 10 1.82 URS00002C5188_12881 25195746,9514737,8510153,8421525,1303744,2585487 12881 uuuuuuuuuu .......... .......... Satellite Tobacco Mosaic Virus Refined at room temperature to 1.8 A Resolution using NCS Restraints; RNA (5'-R(P*UP*UP*UP*UP*UP*UP*UP*UP*UP*U)-3') 4nia d 10 1.82 URS000080DEB3_12881 25195746,9514737,8510153,8421525,1303744,2585487 12881 aaaaaaaaaa .......... .......... Satellite Tobacco Mosaic Virus Refined at room temperature to 1.8 A Resolution using NCS Restraints; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 4nia s 10 1.82 URS00002C5188_12881 25195746,9514737,8510153,8421525,1303744,2585487 12881 uuuuuuuuuu .......... .......... Satellite Tobacco Mosaic Virus Refined at room temperature to 1.8 A Resolution using NCS Restraints; RNA (5'-R(P*UP*UP*UP*UP*UP*UP*UP*UP*UP*U)-3') 4o41 A 11 1.2 URS000080DE24_32630 24813446 32630 gagcncggcuc ........... ........... Amide linked RNA; AMIDE LINKED RNA 4o41 B 12 1.2 URS000080DE24_32630 24813446 32630 ugagcncggcuc ............ ............ Amide linked RNA; AMIDE LINKED RNA 4o41 C 11 1.2 URS000080DE24_32630 24813446 32630 gagcncggcuc ........... ........... Amide linked RNA; AMIDE LINKED RNA 4o41 D 11 1.2 URS000080DE24_32630 24813446 32630 gagcncggcuc ........... ........... Amide linked RNA; AMIDE LINKED RNA 4oog D 34 2.5 URS000080E300_32630 24703949 32630 caugucaugucaugaguccauggcauggcauggc <<<<<<<<<<<<<<....>>>>>>>>>>>>>>.. ((((((((((((((....)))))))))))))).. Crystal structure of yeast RNase III (Rnt1p) complexed with the product of dsRNA processing; 34-mer RNA 4oq8 B 10 1.45 URS000080DEB3_12881 25195746,9514737,8510153,8421525,1303744,2585487,11179893,22750417 12881 aaaaaaaaaa .......... .......... Satellite Tobacco Mosaic Virus Refined to 1.4 A Resolution using icosahedral constraints; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 4oq8 C 10 1.45 URS00002C5188_12881 25195746,9514737,8510153,8421525,1303744,2585487,11179893,22750417 12881 uuuuuuuuuu .......... .......... Satellite Tobacco Mosaic Virus Refined to 1.4 A Resolution using icosahedral constraints; RNA (5'-R(P*UP*UP*UP*UP*UP*UP*UP*UP*UP*U)-3') 4oq9 P 10 1.45 URS000080DEB3_12881 25195746,9514737,8510153,8421525,1303744,2585487,11179893,22750417 12881 aaaaaaaaaa .......... .......... Satellite Tobacco Mosaic Virus Refined to 1.4 A Resolution using non-crystallographic symmetry restraints; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 4oq9 Q 10 1.45 URS000080DEB3_12881 25195746,9514737,8510153,8421525,1303744,2585487,11179893,22750417 12881 aaaaaaaaaa .......... .......... Satellite Tobacco Mosaic Virus Refined to 1.4 A Resolution using non-crystallographic symmetry restraints; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 4oq9 R 10 1.45 URS000080DEB3_12881 25195746,9514737,8510153,8421525,1303744,2585487,11179893,22750417 12881 aaaaaaaaaa .......... .......... Satellite Tobacco Mosaic Virus Refined to 1.4 A Resolution using non-crystallographic symmetry restraints; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 4oq9 S 10 1.45 URS000080DEB3_12881 25195746,9514737,8510153,8421525,1303744,2585487,11179893,22750417 12881 aaaaaaaaaa .......... .......... Satellite Tobacco Mosaic Virus Refined to 1.4 A Resolution using non-crystallographic symmetry restraints; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 4oq9 T 10 1.45 URS000080DEB3_12881 25195746,9514737,8510153,8421525,1303744,2585487,11179893,22750417 12881 aaaaaaaaaa .......... .......... Satellite Tobacco Mosaic Virus Refined to 1.4 A Resolution using non-crystallographic symmetry restraints; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 4oq9 U 10 1.45 URS000080DEB3_12881 25195746,9514737,8510153,8421525,1303744,2585487,11179893,22750417 12881 aaaaaaaaaa .......... .......... Satellite Tobacco Mosaic Virus Refined to 1.4 A Resolution using non-crystallographic symmetry restraints; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 4oq9 V 10 1.45 URS000080DEB3_12881 25195746,9514737,8510153,8421525,1303744,2585487,11179893,22750417 12881 aaaaaaaaaa .......... .......... Satellite Tobacco Mosaic Virus Refined to 1.4 A Resolution using non-crystallographic symmetry restraints; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 4oq9 W 10 1.45 URS000080DEB3_12881 25195746,9514737,8510153,8421525,1303744,2585487,11179893,22750417 12881 aaaaaaaaaa .......... .......... Satellite Tobacco Mosaic Virus Refined to 1.4 A Resolution using non-crystallographic symmetry restraints; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 4oq9 X 10 1.45 URS000080DEB3_12881 25195746,9514737,8510153,8421525,1303744,2585487,11179893,22750417 12881 aaaaaaaaaa .......... .......... Satellite Tobacco Mosaic Virus Refined to 1.4 A Resolution using non-crystallographic symmetry restraints; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 4oq9 Y 10 1.45 URS000080DEB3_12881 25195746,9514737,8510153,8421525,1303744,2585487,11179893,22750417 12881 aaaaaaaaaa .......... .......... Satellite Tobacco Mosaic Virus Refined to 1.4 A Resolution using non-crystallographic symmetry restraints; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 4oq9 Z 10 1.45 URS000080DEB3_12881 25195746,9514737,8510153,8421525,1303744,2585487,11179893,22750417 12881 aaaaaaaaaa .......... .......... Satellite Tobacco Mosaic Virus Refined to 1.4 A Resolution using non-crystallographic symmetry restraints; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 4oq9 a 10 1.45 URS000080DEB3_12881 25195746,9514737,8510153,8421525,1303744,2585487,11179893,22750417 12881 aaaaaaaaaa .......... .......... Satellite Tobacco Mosaic Virus Refined to 1.4 A Resolution using non-crystallographic symmetry restraints; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 4oq9 b 10 1.45 URS000080DEB3_12881 25195746,9514737,8510153,8421525,1303744,2585487,11179893,22750417 12881 aaaaaaaaaa .......... .......... Satellite Tobacco Mosaic Virus Refined to 1.4 A Resolution using non-crystallographic symmetry restraints; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 4oq9 c 10 1.45 URS000080DEB3_12881 25195746,9514737,8510153,8421525,1303744,2585487,11179893,22750417 12881 aaaaaaaaaa .......... .......... Satellite Tobacco Mosaic Virus Refined to 1.4 A Resolution using non-crystallographic symmetry restraints; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 4oq9 d 10 1.45 URS000080DEB3_12881 25195746,9514737,8510153,8421525,1303744,2585487,11179893,22750417 12881 aaaaaaaaaa .......... .......... Satellite Tobacco Mosaic Virus Refined to 1.4 A Resolution using non-crystallographic symmetry restraints; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 4oq9 e 10 1.45 URS00002C5188_12881 25195746,9514737,8510153,8421525,1303744,2585487,11179893,22750417 12881 uuuuuuuuuu .......... .......... Satellite Tobacco Mosaic Virus Refined to 1.4 A Resolution using non-crystallographic symmetry restraints; RNA (5'-R(P*UP*UP*UP*UP*UP*UP*UP*UP*UP*U)-3') 4oq9 f 10 1.45 URS00002C5188_12881 25195746,9514737,8510153,8421525,1303744,2585487,11179893,22750417 12881 uuuuuuuuuu .......... .......... Satellite Tobacco Mosaic Virus Refined to 1.4 A Resolution using non-crystallographic symmetry restraints; RNA (5'-R(P*UP*UP*UP*UP*UP*UP*UP*UP*UP*U)-3') 4oq9 g 10 1.45 URS00002C5188_12881 25195746,9514737,8510153,8421525,1303744,2585487,11179893,22750417 12881 uuuuuuuuuu .......... .......... Satellite Tobacco Mosaic Virus Refined to 1.4 A Resolution using non-crystallographic symmetry restraints; RNA (5'-R(P*UP*UP*UP*UP*UP*UP*UP*UP*UP*U)-3') 4oq9 h 10 1.45 URS00002C5188_12881 25195746,9514737,8510153,8421525,1303744,2585487,11179893,22750417 12881 uuuuuuuuuu .......... .......... Satellite Tobacco Mosaic Virus Refined to 1.4 A Resolution using non-crystallographic symmetry restraints; RNA (5'-R(P*UP*UP*UP*UP*UP*UP*UP*UP*UP*U)-3') 4oq9 i 10 1.45 URS00002C5188_12881 25195746,9514737,8510153,8421525,1303744,2585487,11179893,22750417 12881 uuuuuuuuuu .......... .......... Satellite Tobacco Mosaic Virus Refined to 1.4 A Resolution using non-crystallographic symmetry restraints; RNA (5'-R(P*UP*UP*UP*UP*UP*UP*UP*UP*UP*U)-3') 4oq9 j 10 1.45 URS00002C5188_12881 25195746,9514737,8510153,8421525,1303744,2585487,11179893,22750417 12881 uuuuuuuuuu .......... .......... Satellite Tobacco Mosaic Virus Refined to 1.4 A Resolution using non-crystallographic symmetry restraints; RNA (5'-R(P*UP*UP*UP*UP*UP*UP*UP*UP*UP*U)-3') 4oq9 k 10 1.45 URS00002C5188_12881 25195746,9514737,8510153,8421525,1303744,2585487,11179893,22750417 12881 uuuuuuuuuu .......... .......... Satellite Tobacco Mosaic Virus Refined to 1.4 A Resolution using non-crystallographic symmetry restraints; RNA (5'-R(P*UP*UP*UP*UP*UP*UP*UP*UP*UP*U)-3') 4oq9 l 10 1.45 URS00002C5188_12881 25195746,9514737,8510153,8421525,1303744,2585487,11179893,22750417 12881 uuuuuuuuuu .......... .......... Satellite Tobacco Mosaic Virus Refined to 1.4 A Resolution using non-crystallographic symmetry restraints; RNA (5'-R(P*UP*UP*UP*UP*UP*UP*UP*UP*UP*U)-3') 4oq9 m 10 1.45 URS00002C5188_12881 25195746,9514737,8510153,8421525,1303744,2585487,11179893,22750417 12881 uuuuuuuuuu .......... .......... Satellite Tobacco Mosaic Virus Refined to 1.4 A Resolution using non-crystallographic symmetry restraints; RNA (5'-R(P*UP*UP*UP*UP*UP*UP*UP*UP*UP*U)-3') 4oq9 n 10 1.45 URS00002C5188_12881 25195746,9514737,8510153,8421525,1303744,2585487,11179893,22750417 12881 uuuuuuuuuu .......... .......... Satellite Tobacco Mosaic Virus Refined to 1.4 A Resolution using non-crystallographic symmetry restraints; RNA (5'-R(P*UP*UP*UP*UP*UP*UP*UP*UP*UP*U)-3') 4oq9 o 10 1.45 URS00002C5188_12881 25195746,9514737,8510153,8421525,1303744,2585487,11179893,22750417 12881 uuuuuuuuuu .......... .......... Satellite Tobacco Mosaic Virus Refined to 1.4 A Resolution using non-crystallographic symmetry restraints; RNA (5'-R(P*UP*UP*UP*UP*UP*UP*UP*UP*UP*U)-3') 4oq9 p 10 1.45 URS00002C5188_12881 25195746,9514737,8510153,8421525,1303744,2585487,11179893,22750417 12881 uuuuuuuuuu .......... .......... Satellite Tobacco Mosaic Virus Refined to 1.4 A Resolution using non-crystallographic symmetry restraints; RNA (5'-R(P*UP*UP*UP*UP*UP*UP*UP*UP*UP*U)-3') 4oq9 q 10 1.45 URS00002C5188_12881 25195746,9514737,8510153,8421525,1303744,2585487,11179893,22750417 12881 uuuuuuuuuu .......... .......... Satellite Tobacco Mosaic Virus Refined to 1.4 A Resolution using non-crystallographic symmetry restraints; RNA (5'-R(P*UP*UP*UP*UP*UP*UP*UP*UP*UP*U)-3') 4oq9 r 10 1.45 URS00002C5188_12881 25195746,9514737,8510153,8421525,1303744,2585487,11179893,22750417 12881 uuuuuuuuuu .......... .......... Satellite Tobacco Mosaic Virus Refined to 1.4 A Resolution using non-crystallographic symmetry restraints; RNA (5'-R(P*UP*UP*UP*UP*UP*UP*UP*UP*UP*U)-3') 4oq9 s 10 1.45 URS00002C5188_12881 25195746,9514737,8510153,8421525,1303744,2585487,11179893,22750417 12881 uuuuuuuuuu .......... .......... Satellite Tobacco Mosaic Virus Refined to 1.4 A Resolution using non-crystallographic symmetry restraints; RNA (5'-R(P*UP*UP*UP*UP*UP*UP*UP*UP*UP*U)-3') 4p20 A 21 2.7 URS000080E29E_32630 16806634 32630 gcgucacaccggugaagucgc ..................... ..................... Crystal structures of the bacterial ribosomal decoding site complexed with amikacin; 5'-R(*UP*UP*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*C)-3' 4p20 B 21 2.7 URS000080E29E_32630 16806634 32630 gcgucacaccggugaagucgc ..................... ..................... Crystal structures of the bacterial ribosomal decoding site complexed with amikacin; 5'-R(*UP*UP*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*C)-3' 4p3s A 21 2.3 URS0000A76334_32630 32630 gcgucccgncgacgaagucgc ..................... ..................... Crystal structure of the bacterial A1408C-mutant ribosomal decoding site in complex with geneticin; 5'-R(*UP*UP*GP*CP*GP*UP*CP*CP*CP*GP*(5BU)P*CP*GP*AP*CP*GP*AP*AP*GP*UP*CP*GP*C)-3' 4p3s B 22 2.3 URS0000A76334_32630 32630 ugcgucccgncgacgaagucgc ...................... ...................... Crystal structure of the bacterial A1408C-mutant ribosomal decoding site in complex with geneticin; 5'-R(*UP*UP*GP*CP*GP*UP*CP*CP*CP*GP*(5BU)P*CP*GP*AP*CP*GP*AP*AP*GP*UP*CP*GP*C)-3' 4p3t A 23 1.6 URS0000A76334_32630 32630 uugcgucccgncgacgaagucgc ....................... ....................... Crystal structure of the bacterial A1408C-mutant ribosomal decoding site; 5'-D(*UP*UP*GP*CP*GP*UP*CP*CP*CP*GP*(5BU)P*CP*GP*AP*CP*GP*AP*AP*GP*UP*CP*GP*C)-3' 4p3t B 23 1.6 URS0000A76334_32630 32630 uugcgucccgncgacgaagucgc ....................... ....................... Crystal structure of the bacterial A1408C-mutant ribosomal decoding site; 5'-D(*UP*UP*GP*CP*GP*UP*CP*CP*CP*GP*(5BU)P*CP*GP*AP*CP*GP*AP*AP*GP*UP*CP*GP*C)-3' 4p3u A 21 3.0 URS0000A76342_32630 32630 gcgucucgncgacgaagucgc ..................... ..................... Crystal structure of the bacterial A1408U-mutant ribosomal decoding site (C2 form 1); 5'-R(*UP*UP*GP*CP*GP*UP*CP*UP*CP*GP*(5BU)P*CP*GP*AP*CP*GP*AP*AP*GP*UP*CP*GP*C)-3' 4p3u B 22 3.0 URS0000A76342_32630 32630 ugcgucucgncgacgaagucgc ...................... ...................... Crystal structure of the bacterial A1408U-mutant ribosomal decoding site (C2 form 1); 5'-R(*UP*UP*GP*CP*GP*UP*CP*UP*CP*GP*(5BU)P*CP*GP*AP*CP*GP*AP*AP*GP*UP*CP*GP*C)-3' 4p3u C 22 3.0 URS0000A76342_32630 32630 ugcgucucgncgacgaagucgc ...................... ...................... Crystal structure of the bacterial A1408U-mutant ribosomal decoding site (C2 form 1); 5'-R(*UP*UP*GP*CP*GP*UP*CP*UP*CP*GP*(5BU)P*CP*GP*AP*CP*GP*AP*AP*GP*UP*CP*GP*C)-3' 4p3u D 21 3.0 URS0000A76342_32630 32630 gcgucucgncgacgaagucgc ..................... ..................... Crystal structure of the bacterial A1408U-mutant ribosomal decoding site (C2 form 1); 5'-R(*UP*UP*GP*CP*GP*UP*CP*UP*CP*GP*(5BU)P*CP*GP*AP*CP*GP*AP*AP*GP*UP*CP*GP*C)-3' 4p43 A 21 2.0 URS0000A76342_32630 32630 gcgucucgucgacgaagucgc ..................... ..................... Crystal structure of the bacterial A1408U-mutant ribosomal decoding site (C2 form 2); 5'-R(*UP*UP*GP*CP*GP*UP*CP*UP*CP*GP*UP*CP*GP*AP*CP*GP*AP*AP*GP*UP*CP*GP*C)-3' 4p43 B 23 2.0 URS0000A76342_32630 32630 uugcgucucgucgacgaagucgc ....................... ....................... Crystal structure of the bacterial A1408U-mutant ribosomal decoding site (C2 form 2); 5'-R(*UP*UP*GP*CP*GP*UP*CP*UP*CP*GP*UP*CP*GP*AP*CP*GP*AP*AP*GP*UP*CP*GP*C)-3' 4p6f QA 1500 3.6 RF00177,RF01959,RF01960 URS000080E226_300852 25198768 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggggucuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<...>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<<....>>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((((..(((((((....)))))))...((((....))))..))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((.......(((.....)))......))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Crystal structure of the peptolide 12C bound to bacterial ribosome; 16S ribosomal RNA 4p6f QV 77 3.6 RF00005 URS000041AF00_511145 25198768 0030533 0006412 511145 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the peptolide 12C bound to bacterial ribosome; tRNA-fMet 4p6f QW 76 3.6 RF00005 URS00005AA258_511145 25198768 0030533 0006412 511145 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((........)))).((((.........)))).....(((((.......)))))))))))).... Crystal structure of the peptolide 12C bound to bacterial ribosome; E-Site tRNA-Phe or A-Site tRNA-Phe 4p6f QX 10 3.6 25198768 300852 aaaauguuca .......... .......... Crystal structure of the peptolide 12C bound to bacterial ribosome; mRNA 4p6f QY 17 3.6 RF00005 URS00005AA258_511145 25198768 0030533 0006412 511145 gggauugaaaaucccca .<<<<.....>>>>... .(((.......)))... Crystal structure of the peptolide 12C bound to bacterial ribosome; E-Site tRNA-Phe or A-Site tRNA-Phe 4p6f RA 2882 3.6 RF02540,RF02541,RF00002 URS00001698E8_300852 25198768 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<..>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>......>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<<.....>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[[)))...].((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....(())...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((...((((((......)))).))...))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......(((((.((...(((.........)))...)).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........(((((..(((......((((((((....))))))))...)))............)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(..(((.....))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal structure of the peptolide 12C bound to bacterial ribosome; 23S ribosomal RNA 4p6f RB 120 3.6 RF00001 URS00005F2F4B_300852 25198768 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> (((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).))))))))))) Crystal structure of the peptolide 12C bound to bacterial ribosome; 5S ribosomal RNA 4p6f XA 1500 3.6 RF00177,RF01959,RF01960 URS000080E226_300852 25198768 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggggacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<...>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<<....>>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).(((.(...))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((((..(((((((....)))))))...((((....))))..))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((.......(((.....)))......)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Crystal structure of the peptolide 12C bound to bacterial ribosome; 16S ribosomal RNA 4p6f XV 77 3.6 RF00005 URS000041AF00_511145 25198768 0030533 0006412 511145 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the peptolide 12C bound to bacterial ribosome; tRNA-fMet 4p6f XW 76 3.6 RF00005 URS00005AA258_511145 25198768 0030533 0006412 511145 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<.........>>>>>>>>>>>.... ((((.((..((((........)))).((((.........)))).....(((.(.......).))))).)))).... Crystal structure of the peptolide 12C bound to bacterial ribosome; E-Site tRNA-Phe or A-Site tRNA-Phe 4p6f XX 10 3.6 25198768 300852 aaaauguuca .......... .......... Crystal structure of the peptolide 12C bound to bacterial ribosome; mRNA 4p6f XY 17 3.6 RF00005 URS00005AA258_511145 25198768 0030533 0006412 511145 gggauugaaaaucccca .<<<<.....>>>>... .(((.......)))... Crystal structure of the peptolide 12C bound to bacterial ribosome; E-Site tRNA-Phe or A-Site tRNA-Phe 4p6f YA 2883 3.6 RF02540,RF02541,RF00002 URS00001698E8_300852 25198768 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<..>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<..>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<<<<<<<<...<<.......>>...>>>>>>>..>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<<.....>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[[)))...].((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((..)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....(())...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((...((((((......)))).))...))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......(((((.(((..(((.........)))..))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((.(((((((((.(.........(((((..(((......((((((((....))))))))...)))............)))))).))))))))).))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.((((.....))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal structure of the peptolide 12C bound to bacterial ribosome; 23S ribosomal RNA 4p6f YB 120 3.6 RF00001 URS00005F2F4B_300852 25198768 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> (((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).))))))))))) Crystal structure of the peptolide 12C bound to bacterial ribosome; 5S ribosomal RNA 4p70 QA 1500 3.68 RF00177,RF01959,RF01960 URS000080E226_300852 25128388 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggggucuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<...>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<......>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(.(((....)))..))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((.(((((...))))).))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((..((((((.((..(((((..((((((((((......((........))..........(((((((..(...(.((((((..((((((......))))))...((((....))))..)))))).)).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.((((((........(((.....))).......)))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))).))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Crystal Structure of Unmodified tRNA Proline (CGG) Bound to Codon CCG on the Ribosome; 16S rRNA 4p70 RA 2882 3.68 RF02540,RF02541,RF00002 URS000080DFFB_300852 25128388 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu .<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>....<<<<<.....<......>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<..>...>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<<.....>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>. .((......((((((((((.....(((..((((((((((((......((((((.[[..[[[)))...].((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...((((......((.]...)).....))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....((((((((..[......))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...........)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((.(((...(((...((((((((...((((..........)).))...))))))))..)).)...))).)))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((........((((.((...(((.........)))...)).........((......))...))))....)))))))))).))..........]]].)....))))))))))...)))))))(((((((.......)))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...(((((((((((((((..((.....)).)))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........((..(..((.......((....((....))....))....))............)..))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....((((((..((..]]]]..)).)))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(....(.....).......(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...))). Crystal Structure of Unmodified tRNA Proline (CGG) Bound to Codon CCG on the Ribosome; 23S rRNA 4p70 RB 120 3.68 RF00001 URS00005F2F4B_300852 25128388 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> .((((((((((....((((((.(....(((((((...(.....)...))))..)))...).)))).))(((.......((.(((((....))))).)).......))).)))))))))). Crystal Structure of Unmodified tRNA Proline (CGG) Bound to Codon CCG on the Ribosome; 5S rRNA 4p70 XA 1500 3.68 RF00177,RF01959,RF01960 URS000080E226_300852 25128388 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggggacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<...>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>....<<<<.<<<<<....>>>>>.>>>>...<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<......>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((.((((((.)))))).))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((.(((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..)))))..))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...((((((((..(((((((....)))))))...((((....))))..))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...(...(((.....)))).....)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....))))))))..)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....((((.((..........)).))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Crystal Structure of Unmodified tRNA Proline (CGG) Bound to Codon CCG on the Ribosome; 16S rRNA 4p70 YA 2883 3.68 RF02540,RF02541,RF00002 URS000080DFFB_300852 25128388 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu 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(((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((..)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.((.((((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).))))))..))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....(())...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((...((.(((......)))..))...))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......(((((.((...(((.........)))...)).....(...(........).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.........((((.((((((..(((((.(((.(((((.((((((.((((.(((..(.........((((...(.(......(((((.((....)).)))))...).).............)))))..))).)))).))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.....)))))))))))[...(((((((...((((..(((((((...............))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(...((.....))......(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal Structure of Unmodified tRNA Proline (CGG) Bound to Codon CCG on the Ribosome; 23S rRNA 4p70 YB 120 3.68 RF00001 URS00005F2F4B_300852 25128388 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> (((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......(..(((((....)))))..).......))).))))))))))) Crystal Structure of Unmodified tRNA Proline (CGG) Bound to Codon CCG on the Ribosome; 5S rRNA 4p70 QV 77 3.68 RF00005 URS000041AF00_1110693 25128388 0030533 0006412 1110693 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal Structure of Unmodified tRNA Proline (CGG) Bound to Codon CCG on the Ribosome; P-site tRNA fMET 4p70 XV 77 3.68 RF00005 URS000041AF00_1110693 25128388 0030533 0006412 1110693 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal Structure of Unmodified tRNA Proline (CGG) Bound to Codon CCG on the Ribosome; P-site tRNA fMET 4p97 A 16 1.86 URS00008116B2_390157 25349403 390157 cgucuacccaccucgc ................ ................ Functional conservation despite structural divergence in ligand-responsive RNA switches; RNA (5'-R(*CP*GP*UP*CP*UP*AP*CP*CP*CP*AP*CP*CP*UP*CP*GP*C)-3') 4p97 B 11 1.86 URS00008116A5_390157 25349403 390157 cgagaggacgg ........... ........... Functional conservation despite structural divergence in ligand-responsive RNA switches; RNA (5'-R(*CP*GP*AP*GP*AP*GP*GP*AP*CP*GP*G)-3') 4p97 C 16 1.86 URS00008116B2_390157 25349403 390157 cgucuacccaccucgc ................ ................ Functional conservation despite structural divergence in ligand-responsive RNA switches; RNA (5'-R(*CP*GP*UP*CP*UP*AP*CP*CP*CP*AP*CP*CP*UP*CP*GP*C)-3') 4p97 D 11 1.86 URS00008116A5_390157 25349403 390157 cgagaggacgg ........... ........... Functional conservation despite structural divergence in ligand-responsive RNA switches; RNA (5'-R(*CP*GP*AP*GP*AP*GP*GP*AP*CP*GP*G)-3') 4pco A 10 1.32 URS000086854C_40263 26425937 40263 gguggcuguu .......... .......... Crystal structure of double-stranded RNA with four terminal GU wobble base pairs; RNA (5'-D(*GP*GP*UP*GP*GP*CP*UP*GP*UP*U)-3') 4pco B 10 1.32 URS000086854C_40263 26425937 40263 gguggcuguu .......... .......... Crystal structure of double-stranded RNA with four terminal GU wobble base pairs; RNA (5'-D(*GP*GP*UP*GP*GP*CP*UP*GP*UP*U)-3') 4pco C 10 1.32 URS000086854C_40263 26425937 40263 gguggcuguu .......... .......... Crystal structure of double-stranded RNA with four terminal GU wobble base pairs; RNA (5'-D(*GP*GP*UP*GP*GP*CP*UP*GP*UP*U)-3') 4pco D 10 1.32 URS000086854C_40263 26425937 40263 gguggcuguu .......... .......... Crystal structure of double-stranded RNA with four terminal GU wobble base pairs; RNA (5'-D(*GP*GP*UP*GP*GP*CP*UP*GP*UP*U)-3') 4pco E 10 1.32 URS000086854C_40263 26425937 40263 gguggcuguu .......... .......... Crystal structure of double-stranded RNA with four terminal GU wobble base pairs; RNA (5'-D(*GP*GP*UP*GP*GP*CP*UP*GP*UP*U)-3') 4pdq A 23 3.0 URS000080DDE4_32630 32630 uugcgucacgccggcgaagucgc ....................... ....................... Crystal structure of the bacterial ribosomal decoding site in complex with 4'-deoxy-4'-fluoro neomycin analog; RNA (5'-*UP*UP*GP*CP*GP*UP*CP*AP*CP*GP*CP*CP*GP*GP*CP*GP*AP*AP*GP*UP*CP*GP*C-3') 4pdq B 23 3.0 URS000080DDE4_32630 32630 uugcgucacgccggcgaagucgc ....................... ....................... Crystal structure of the bacterial ribosomal decoding site in complex with 4'-deoxy-4'-fluoro neomycin analog; RNA (5'-*UP*UP*GP*CP*GP*UP*CP*AP*CP*GP*CP*CP*GP*GP*CP*GP*AP*AP*GP*UP*CP*GP*C-3') 4phy A 26 3.1 URS000080DECA_390157 25349403 390157 cgugcuccccaccucggaucacugcg .......................... .......................... Functional conservation despite structural divergence in ligand-responsive RNA switches; RNA (26-MER) 4phy B 20 3.1 URS000080E149_390157 25349403 390157 gcaggaaccgagaggcacgc .................... .................... Functional conservation despite structural divergence in ligand-responsive RNA switches; RNA (5'-R(*GP*CP*AP*GP*GP*AP*AP*CP*CP*GP*AP*GP*AP*GP*GP*CP*AP*CP*GP*C)-3') 4pjo 1 48 3.3 URS000080E380_9606 25555158 9606 ngacuuaccuggcagugaggugcacacacugcauaauuugugguagug ...........<<<<<<.........>>>>>>................ ...........((((((.........))))))................ Minimal U1 snRNP; U1 RNA variant (48-MER) with 4-helix junction replaced by kissing loop (HIV-1 (Mal) DIS) and shorter stem-loop 4. 4pjo X 10 3.3 URS000080E0CC_9606 25555158 9606 agguaagucc .......... .......... Minimal U1 snRNP; RNA (5'-R(*AP*GP*GP*UP*AP*AP*GP*UP*CP*C)-3') 4pjo 2 48 3.3 URS000080E380_9606 25555158 9606 ngacuuaccuggcagugaggugcacacacugcauaauuugugguagug ...........<<<<<<.........>>>>>>................ ...........((((((.........))))))................ Minimal U1 snRNP; U1 RNA variant (48-MER) with 4-helix junction replaced by kissing loop (HIV-1 (Mal) DIS) and shorter stem-loop 4. 4pjo x 10 3.3 URS000080E0CC_9606 25555158 9606 agguaagucc .......... .......... Minimal U1 snRNP; RNA (5'-R(*AP*GP*GP*UP*AP*AP*GP*UP*CP*C)-3') 4pjo 3 47 3.3 URS000080E380_9606 25555158 9606 ngacuuaccuggcagugaggugcacacacugcauaauuugugguagu ...........<<<<<<.........>>>>>>............... ...........((((((.........))))))............... Minimal U1 snRNP; U1 RNA variant (48-MER) with 4-helix junction replaced by kissing loop (HIV-1 (Mal) DIS) and shorter stem-loop 4. 4pjo Y 10 3.3 URS000080E0CC_9606 25555158 9606 agguaagucc .......... .......... Minimal U1 snRNP; RNA (5'-R(*AP*GP*GP*UP*AP*AP*GP*UP*CP*C)-3') 4pjo 4 49 3.3 URS000080E380_9606 25555158 9606 ngacuuaccuggcagugaggugcacacacugcauaauuugugguagugg ...........<<<<<<.........>>>>>>................. ...........((((((.........))))))................. Minimal U1 snRNP; U1 RNA variant (48-MER) with 4-helix junction replaced by kissing loop (HIV-1 (Mal) DIS) and shorter stem-loop 4. 4pjo y 10 3.3 URS000080E0CC_9606 25555158 9606 agguaagucc .......... .......... Minimal U1 snRNP; RNA (5'-R(*AP*GP*GP*UP*AP*AP*GP*UP*CP*C)-3') 4qik C 18 1.9 URS000080DEFB_32630 25026078 32630 auguuuucuggaaaacgg .................. .................. Crystal structure of the ROQ domain of human Roquin in complex with the TNF23 RNA duplex; 5'-R(*AP*C*AP*UP*GP*UP*UP*UP*UP*CP*UP*GP*UP*GP*AP*AP*AP*AP*CP*GP*GP*AP*G)-3' 4qik D 18 1.9 URS000080DEFB_32630 25026078 32630 guuuucugugaaaacgga .................. .................. Crystal structure of the ROQ domain of human Roquin in complex with the TNF23 RNA duplex; 5'-R(*AP*C*AP*UP*GP*UP*UP*UP*UP*CP*UP*GP*UP*GP*AP*AP*AP*AP*CP*GP*GP*AP*G)-3' 4qjd A 24 3.1 URS000080DE8E_32630 25157168 32630 uguaacuccgccuaugucaucuua ........................ ........................ Crystal Structure of Twister with the Nucleotide 5'- to the Cleavage Site Disordered at 3.1 A Resolution; Twister RNA sequence 4qjd B 47 3.1 RF03160 URS000080DED8_32630 25157168 0003824 32630 nuaaaugauauagccggucccaagcccggaaaaaggaggaggguaua .............<<<<.(((....>>>>...........))).... .............((((.[[[....))))...........]]].... Crystal Structure of Twister with the Nucleotide 5'- to the Cleavage Site Disordered at 3.1 A Resolution; Twister RNA sequence 4qjd C 25 3.1 URS000080DE8E_32630 25157168 32630 uauguaacuccgccuaugucaucuu ......................... ......................... Crystal Structure of Twister with the Nucleotide 5'- to the Cleavage Site Disordered at 3.1 A Resolution; Twister RNA sequence 4qjd D 47 3.1 RF03160 URS000080DED8_32630 25157168 0003824 32630 nuaaaugauauagccggucccaagcccggaaaaaggaggaggguaua .............<<<<.(((....>>>>...........))).... .............((((.[[[....))))...........]]].... Crystal Structure of Twister with the Nucleotide 5'- to the Cleavage Site Disordered at 3.1 A Resolution; Twister RNA sequence 4qjd E 26 3.1 URS000080DE8E_32630 25157168 32630 uauguaacuccgccuaugucaucuua .......................... .......................... Crystal Structure of Twister with the Nucleotide 5'- to the Cleavage Site Disordered at 3.1 A Resolution; Twister RNA sequence 4qjd F 47 3.1 RF03160 URS000080DED8_32630 25157168 0003824 32630 nuaaaugauauagccggucccaagcccggaaaaaggaggaggguaua .............<<<<.(((....>>>>...........))).... .............((((.[[[....))))...........]]].... Crystal Structure of Twister with the Nucleotide 5'- to the Cleavage Site Disordered at 3.1 A Resolution; Twister RNA sequence 4qjd G 25 3.1 URS000080DE8E_32630 25157168 32630 uauguaacuccgccuaugucaucuu ......................... ......................... Crystal Structure of Twister with the Nucleotide 5'- to the Cleavage Site Disordered at 3.1 A Resolution; Twister RNA sequence 4qjd H 47 3.1 RF03160 URS000080DED8_32630 25157168 0003824 32630 nuaaaugauauagccggucccaagcccggaaaaaggaggaggguaua .............<<<<.(((....>>>>...........))).... .............((((.[[[....))))...........]]].... Crystal Structure of Twister with the Nucleotide 5'- to the Cleavage Site Disordered at 3.1 A Resolution; Twister RNA sequence 4qjh A 26 3.88 URS000080DF67_32630 25157168 32630 cgcggcauuaaugcagcuuuauugcc .......................... .......................... Crystal Structure of the Twister Ribozyme with the Nucleotide 5'- to the Cleavage Site Ordered at 4.1 A Resolution; Twister Ribozyme 4qjh B 48 3.88 URS000080E16D_32630 25157168 32630 ngcaauaaagcgguuacaagcccgcaaaaauagcagaguaaugucgcg .........<<<<.(((....>>>>............)))........ .........((((..[[....))))............]]......... Crystal Structure of the Twister Ribozyme with the Nucleotide 5'- to the Cleavage Site Ordered at 4.1 A Resolution; Twister Ribozyme 4qjh C 26 3.88 URS000080DF67_32630 25157168 32630 cgcggcauuaaugcagcuuuauugcc .......................... .......................... Crystal Structure of the Twister Ribozyme with the Nucleotide 5'- to the Cleavage Site Ordered at 4.1 A Resolution; Twister Ribozyme 4qjh D 48 3.88 URS000080E16D_32630 25157168 32630 ngcaauaaagcgguuacaagcccgcaaaaauagcagaguaaugucgcg .........<<<<.((.....>>>>.............))........ .........((((.[[.....)))).............]]........ Crystal Structure of the Twister Ribozyme with the Nucleotide 5'- to the Cleavage Site Ordered at 4.1 A Resolution; Twister Ribozyme 4qjh E 26 3.88 URS000080DF67_32630 25157168 32630 cgcggcauuaaugcagcuuuauugcc .......................... .......................... Crystal Structure of the Twister Ribozyme with the Nucleotide 5'- to the Cleavage Site Ordered at 4.1 A Resolution; Twister Ribozyme 4qjh F 48 3.88 URS000080E16D_32630 25157168 32630 ngcaauaaagcgguuacaagcccgcaaaaauagcagaguaaugucgcg .........<<<<.(((....>>>>............)))........ .........((((.[[[....))))............]]]........ Crystal Structure of the Twister Ribozyme with the Nucleotide 5'- to the Cleavage Site Ordered at 4.1 A Resolution; Twister Ribozyme 4qln A 117 2.65 RF00379 URS000080E09A_273068 25086509 0180001 0010468 273068 gaucgcugaacccgaaggggcgggggacccagggggcgaaucucuuccgaaaggaagaguaggguuacuccuucgacccgagcccgucagcuaaccucgcaagcguccgaaggagaa ...[[[[...<<<...>>>((((((....{...[[[[....<<<<<<<....>>>>>>>..(((((.<<<<<<<)))))..]]]]....}....)))))).]]]]...>>>>>>>.. ...((((...(((...)))((((((....(..(((((....(((((((....)))))))..(((((.[[[[[[[)))))..))))..).)....)))))).))))...]]]]]]].. structure of ydao riboswitch binding with c-di-dAMP; RNA (117-MER) 4r0d A 617 3.676 RF02012,RF00029 URS000080DD74_2885 25252982 0000373 2885 gugcgacaagaaguucaggaagggauugaggugaaaguccuccucccgaaucguucaugggagagucuauccagacuugcguagcgaguaaucgcuaggugagaagcucuggagacaauguaccugcccuucaauuggaggugccagggcuaggcuuuguuccuauggcuagcgaaagcgaauacagguuauaggcgucgugaaaacaaaacucuuucgacauaagggagagguagaugaguuacccuccuuuuuaugggguaacugaacgaucaauaucuaccggcguagacugugagccuaaaggaaacgaaugaaagugucccuuccugggaacuugguaagcccaauagacucccucugggaaaccagaggaggaguaagagcaaucuuacuuaucgucuaguggguaaaagacauaauaggaagcaaaugcuugguuguaacgaucgagauagaaucuguugauuuaagcugaaaggcugcagacuuauuaaauggguguucugcuguauggcguucgcgccuaagcagcagaaugcgugagccgugugcgaugaaagucgcaagcacgguucugauggggggaaaacgagagaucgucuaccuauccaacu ..[[..<<<....<<<<<<<<<<<<<.<<<<.......>>>><<<<<<.(((({{..>>>>>><<<<<.<<<<<<<<<<<.<<<<<<....>>>>>>.>>>>>..]]>>>>>>......<<.<<......<<....>>........>>>>.>>>>>..<<<<<<..<<<<.<<....>>...<<<<<......(<<<<<...............<<<........>>>....<<<<<<.<<<<<<<<<.).......>>>>>>>>>}}.))))....>>>>>>.>>>>>...>>>>>>>>>...>>>.>>>..........>>>>>>>>>>>>>...>>>....<<<<<.<<<<<..<<<<<<<....>>>>>>>..<<<<<<<<....>>>>>>>>...>>>>>.>>>>>........<<<<<....<<.....<<<<<<<.....>>>>>>>...<<<........>>>.<<<<....>>>>>>.....>>>>>.....<<<<<<<<<<<<..<<<<....>>>>...>>>>>>>>>>>>..<<<<<<<<<<<<<<....>>>>>..>>>>>>>>>...<<<.<<<.<.<<<<....>>>>.>.>>>..>>>... ..{{..((((...(((((((((((((.((((.......))))((((((.[[[[[[..))))))(((((.(((((((((((.((((((....)))))).)))))..}}))))))......(..((((.................).))).).)))))..(((((...((((.((....))...(((((......[((((((............(.((...........)).).((((((..(((((((..]........)))))))..]]]]]]....))))))))))))...)))))))))....)).)))..........)))))))))))))..))))....(((((.(((((..(((((((....)))))))..((((((((....))))))))...))))).)))))........(((((....((.....((.((((.....)))).))..[((((...]..)))).((((....)))))).....))))).....((((((((((((..((((....))))...))))))))))))..((.(((((((((((....)))))..)))))).))...(((.(((...(((......)))...)))..)))... Crystal structure of a eukaryotic group II intron lariat; GROUP IIB INTRON LARIAT 4r0d B 14 3.676 URS000080E2B8_2885 25252982 2885 uguuuauuaaaaac .............. .............. Crystal structure of a eukaryotic group II intron lariat; LIGATED EXONS 4r4p A 186 3.07 URS000086851B_5140 26414446 5140 ngcgcugugucgcaaucugcgaagggcgucgucggcccgagcgguaguaagcagggaacucaccuccaaugaaacacauugucguagcaguugacuacuguuaugugauugguagaggcuaagugacgguauuggcguaagccaauaccgcggcacagcacaagcccgcuugcgagauuacagcgc .<<<<<<<<<<.....<<<<...<<<<.......>>>>..>>>>..<<<<<<.<<<..<<<<<<..<<<<<.....>>>>>..<<<<<<<<.....>>>>>>>>......>>>.>>><<<..<<<.<<<<<<<<<<....>>>>>>>>>>...>>>>>>.....>>>>>>>>>..>>>.>>>>>>> .((((((((((.....((((...((((.......))))..))))..((((((.(((..((((((..(((((.....)))))..(((((((.......)))))))......))).)))(((..(((.((((((((((....))))))))))...)))))).....)))))))))..))).))))))) Crystal Structure of the VS ribozyme-A756G mutant; VS ribozyme RNA 4r4v A 186 3.07 URS0000868529_5140 26414446 5140 ngcgcugugucgcaaucugcgaagggcgucgucggcccaagcgguaguaagcagggaacucaccuccaaugaaacacauugucguagcaguugacuacuguuaugugauugguagaggcuaagugacgguauuggcguaagccaauaccgcagcacagcacaagcccgcuugcgagauuacagcgc .<<<<<<<<<<.....<<<<...<<<<.......>>>>..>>>>..<<<<<<.<<<..<<<<<<..<<<<<.....>>>>>..<<<<<<<<.....>>>>>>>>......>>>.>>><<<..<<<.<<<<<<<<<<....>>>>>>>>>>...>>>>>>.....>>>>>>>>>..>>>.>>>>>>> .((((((((((.....((((...((((.......))))..))))..((((((.(((..((((((..(((((.....)))))..(((((((.......)))))))......))).)))(((..(((.((((((((((....))))))))))...)))))).....)))))))))..))).))))))) Crystal structure of the VS ribozyme - G638A mutant; VS ribozyme RNA 4rbq A 32 1.05 URS00008FED44_32630 25352146 32630 agagaagaaagggaaauuuuuuuuuuuuuuuu ................................ ................................ 32 base pair oligo(U) RNA; U-Helix RNA from Trypanosome editing 4rby A 12 1.19 URS000080E0B7_32630 32630 cgcnaauuagcg ............ ............ First X-ray structure of RNA containing guanosine phosphorodithioate; 5'-R(*CP*GP*CP*(2SG)P*AP*AP*UP*UP*AP*GP*CP*G)-3' 4rbz A 12 1.18 URS0000868561_32630 32630 cgcgnnuuagcg ............ ............ X-ray structure of RNA containing adenosine phosphorodithioate; 5'-R(*CP*GP*CP*GP*(A2M)P*(ADS)P*UP*UP*AP*GP*CP*G)-3' 4rc0 A 12 1.13 URS000080E0B7_32630 32630 cgcgaauunncg ............ ............ X-ray structure of RNA containing guanosine phosphorodithioate; 5'-R(*CP*GP*CP*GP*AP*AP*UP*UP*(A2M)P*(2SG)P*CP*G)-3' 4rmo B 45 2.2 URS000086854B_32630 26350213 32630 aaguuuaccacugaccgauaugugguauauaaauggucggguugn ......<<<<<...(((((..>>>>>.........)))))..... ......(((((...[[[[[..))))).........]]]]]..... Crystal Structure of the CptIN Type III Toxin-Antitoxin System from Eubacterium rectale; RNA (45-MER) 4rmo D 45 2.2 URS000086854B_32630 26350213 32630 aaguuuaccacugaccgauaugugguauauaaauggucggguugn ......<<<<<...(((((..>>>>>.........)))))..... ......(((((...[[[[[..))))).........]]]]]..... Crystal Structure of the CptIN Type III Toxin-Antitoxin System from Eubacterium rectale; RNA (45-MER) 4rmo F 45 2.2 URS000086854B_32630 26350213 32630 aaguuuaccacugaccgauaugugguauauaaauggucggguugn ......<<<<<...(((((..>>>>>.........)))))..... ......(((((...[[[[[..))))).........]]]]]..... Crystal Structure of the CptIN Type III Toxin-Antitoxin System from Eubacterium rectale; RNA (45-MER) 4rmo H 45 2.2 URS000086854B_32630 26350213 32630 aaguuuaccacugaccgauaugugguauauaaauggucggguugn ......<<<<<...(((((..>>>>>.........)))))..... ......(((((...[[[[[..))))).........]]]]]..... Crystal Structure of the CptIN Type III Toxin-Antitoxin System from Eubacterium rectale; RNA (45-MER) 4rmo J 45 2.2 URS000086854B_32630 26350213 32630 aaguuuaccacugaccgauaugugguauauaaauggucggguugn ......<<<<<...(((((..>>>>>.........)))))..... ......(((((...[[[[[..))))).........]]]]]..... Crystal Structure of the CptIN Type III Toxin-Antitoxin System from Eubacterium rectale; RNA (45-MER) 4rmo L 45 2.2 URS000086854B_32630 26350213 32630 aaguuuaccacugaccgauaugugguauauaaauggucggguugn ......<<<<<...(((((..>>>>>.........)))))..... ......(((((...[[[[[..))))).........]]]]]..... Crystal Structure of the CptIN Type III Toxin-Antitoxin System from Eubacterium rectale; RNA (45-MER) 4rmo N 45 2.2 URS000086854B_32630 26350213 32630 aaguuuaccacugaccgauaugugguauauaaauggucggguugn ......<<<<<...(((((..>>>>>.........)))))..... ......(((((...[[[[[..))))).........]]]]]..... Crystal Structure of the CptIN Type III Toxin-Antitoxin System from Eubacterium rectale; RNA (45-MER) 4rmo P 45 2.2 URS000086854B_32630 26350213 32630 aaguuuaccacugaccgauaugugguauauaaauggucggguugn ......<<<<<...(((((..>>>>>.........)))))..... ......(((((...[[[[[..))))).........]]]]]..... Crystal Structure of the CptIN Type III Toxin-Antitoxin System from Eubacterium rectale; RNA (45-MER) 4rwn B 19 2.0 URS00008116AE_32630 25892109 32630 ggcuuuugaccuuuaugaa ................... ................... Crystal structure of the pre-reactive state of porcine OAS1; RNA (5'-R(*GP*GP*CP*UP*UP*UP*UP*GP*AP*CP*CP*UP*UP*UP*AP*UP*GP*AP*A)-3') 4rwn C 19 2.0 URS00008116A9_32630 25892109 32630 uucauaaaggucaaaagcc ................... ................... Crystal structure of the pre-reactive state of porcine OAS1; RNA (5'-R(*UP*UP*CP*AP*UP*AP*AP*AP*GP*GP*UP*CP*AP*AP*AP*AP*GP*CP*C)-3') 4rwo B 19 2.2 URS00008116AE_32630 25892109 32630 ggcuuuugaccuuuaugaa ................... ................... Crystal structure of the porcine OAS1 L149R mutant in complex with dsRNA and ApCpp in the AMP donor position; RNA (5'-R(*GP*GP*CP*UP*UP*UP*UP*GP*AP*CP*CP*UP*UP*UP*AP*UP*GP*AP*A)-3') 4rwo C 19 2.2 URS00008116A9_32630 25892109 32630 uucauaaaggucaaaagcc ................... ................... Crystal structure of the porcine OAS1 L149R mutant in complex with dsRNA and ApCpp in the AMP donor position; RNA (5'-R(*UP*UP*CP*AP*UP*AP*AP*AP*GP*GP*UP*CP*AP*AP*AP*AP*GP*CP*C)-3') 4rwp B 19 2.25 URS00008116AE_32630 25892109 32630 ggcuuuugaccuuuaugaa ................... ................... Crystal structure of porcine OAS1 in complex with dsRNA; RNA (5'-R(*GP*GP*CP*UP*UP*UP*UP*GP*AP*CP*CP*UP*UP*UP*AP*UP*GP*AP*A)-3') 4rwp C 18 2.25 URS00008116A9_32630 25892109 32630 ucauaaaggucaaaagcc .................. .................. Crystal structure of porcine OAS1 in complex with dsRNA; RNA (5'-R(*UP*UP*CP*AP*UP*AP*AP*AP*GP*GP*UP*CP*AP*AP*AP*AP*GP*CP*C)-3') 4s3n B 19 2.0 URS00008116AE_32630 25775560 32630 ggcuuuugaccuuuaugaa ................... ................... Crystal structure of human OAS3 domain I in complex with dsRNA; RNA (5'-R(*GP*GP*CP*UP*UP*UP*UP*GP*AP*CP*CP*UP*UP*UP*AP*UP*GP*AP*A)-3') 4s3n C 19 2.0 URS00008116A9_32630 25775560 32630 uucauaaaggucaaaagcc ................... ................... Crystal structure of human OAS3 domain I in complex with dsRNA; RNA (5'-R(*UP*UP*CP*AP*UP*AP*AP*AP*GP*GP*UP*CP*AP*AP*AP*AP*GP*CP*C)-3') 4ts0 X 44 2.8 URS000080DEC5_32630 25026079 32630 gacgcgaccgaaugaaauggugaaggacggguccagccggcugn ............................................ ............................................ Crystal structure of the Spinach RNA aptamer in complex with DFHBI, barium ions; Spinach RNA aptamer, bimolecular construct 4ts0 Y 47 2.8 URS000080DEDB_32630 25026079 32630 gcagccggcuuguugaguagagugugagcuccguaacuggucgcgun ............................................... ............................................... Crystal structure of the Spinach RNA aptamer in complex with DFHBI, barium ions; Spinach RNA aptamer, bimolecular construct 4ts2 X 44 2.884 URS000080DEC5_32630 25026079 32630 gacgcgaccgaaugaaauggugaaggacggguccagccggcugn ............................................ ............................................ Crystal structure of the Spinach RNA aptamer in complex with DFHBI, magnesium ions; Spinach aptamer RNA, bimolecular construct 4ts2 Y 47 2.884 URS000080DEDB_32630 25026079 32630 gcagccggcuuguugaguagagugugagcuccguaacuggucgcgun ............................................... ............................................... Crystal structure of the Spinach RNA aptamer in complex with DFHBI, magnesium ions; Spinach aptamer RNA, bimolecular construct 4tua QA 1500 3.6 RF00177,RF01959,RF01960 URS000080E226_300852 25352689 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggggucuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<...>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<<....>>>>..>>>>>>>>..<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>....>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((.......(((....))).....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((((..(((((((....)))))))...((((....))))..))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((.......(((.....)))......))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Crystal structure of ASL-Thr bound to Codon ACC-A on the Ribosome; 16S rRNA 4tua QV 77 3.6 RF00005 URS000041AF00_316385 25352689 0030533 0006412 316385 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of ASL-Thr bound to Codon ACC-A on the Ribosome; P-site tRNA-fMet 4tua QX 11 3.6 25352689 32630 aaugaccaaaa ........... ........... Crystal structure of ASL-Thr bound to Codon ACC-A on the Ribosome; messenger RNA 4tua QY 15 3.6 URS00008116B9_32630 25352689 32630 acccuugguaagggu <<<<<.....>>>>> ((((.......)))) Crystal structure of ASL-Thr bound to Codon ACC-A on the Ribosome; A-site ASL-Thr 4tua RA 2882 3.6 RF02540,RF02541,RF00002 URS00001698E8_300852 25352689 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<..>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>......>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<<.....>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[[)))...].((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....(())...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((.(.((((((......)))).)))..))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......(((((.((...(((.........)))...)).........((......))...)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........(((((..(((......(((((.((....)).)))))...)))............)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(...((.....))......(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal structure of ASL-Thr bound to Codon ACC-A on the Ribosome; 23S rRNA 4tua RB 120 3.6 RF00001 URS00005F2F4B_300852 25352689 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> (((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).))))))))))) Crystal structure of ASL-Thr bound to Codon ACC-A on the Ribosome; 5S rRNA 4tua XA 1500 3.6 RF00177,RF01959,RF01960 URS000080E226_300852 25352689 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggggacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<...>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<<....>>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((.(.).)))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((((..(((((((....)))))))...((((....))))..))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...(...(((.....)))).....)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Crystal structure of ASL-Thr bound to Codon ACC-A on the Ribosome; 16S rRNA 4tua XV 77 3.6 RF00005 URS000041AF00_316385 25352689 0030533 0006412 316385 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of ASL-Thr bound to Codon ACC-A on the Ribosome; P-site tRNA-fMet 4tua XX 11 3.6 25352689 32630 aaugaccaaaa ........... ........... Crystal structure of ASL-Thr bound to Codon ACC-A on the Ribosome; messenger RNA 4tua XY 16 3.6 URS00008116B9_32630 25352689 32630 acccuugguaagggug <<<<<.....>>>>>. ((((.......)))). Crystal structure of ASL-Thr bound to Codon ACC-A on the Ribosome; A-site ASL-Thr 4tua YA 2882 3.6 RF02540,RF02541,RF00002 URS00001698E8_300852 25352689 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<..>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<.<.........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>>.>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<<<<<<<<...<<.......>>...>>>>>>>..>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<<.....>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....(())...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((...((((((......)))).))...)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......(((((.((...(((.........)))...)).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((.(((((((((.(.........(((((..(((......((((((((....))))))))...)))............)))))).))))))))).))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(..(((.....))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal structure of ASL-Thr bound to Codon ACC-A on the Ribosome; 23S rRNA 4tua YB 120 3.6 RF00001 URS00005F2F4B_300852 25352689 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> (((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).))))))))))) Crystal structure of ASL-Thr bound to Codon ACC-A on the Ribosome; 5S rRNA 4tub QA 1500 3.6 RF00177,RF01959,RF01960 URS000080E226_300852 25352689 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggggucuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<...>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<<....>>>>..>>>>>>>>..<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>....>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((((..(((((((....)))))))...((((....))))..))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((.......(((.....)))......))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Crystal structure of tRNA-Thr bound to Codon ACC-C on the Ribosome; 16S rRNA 4tub QV 77 3.6 RF00005 URS000041AF00_1403831 25352689 0030533 0006412 1403831 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of tRNA-Thr bound to Codon ACC-C on the Ribosome; P-site tRNA f-Met 4tub QY 16 3.6 URS00008116B9_1403831 25352689 1403831 acccuugguaagggug <<<<<.....>>>>>. ((((.......)))). Crystal structure of tRNA-Thr bound to Codon ACC-C on the Ribosome; A-site tRNA Thr 4tub RA 2882 3.6 RF02540,RF02541,RF00002 URS00001698E8_300852 25352689 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>....<<<<<.....<......>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<..>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<<.....>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....(())...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((...((((((......)))).))...))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......(((((.((....((.........))....)).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........(((((..(((......(((((.((....)).)))))...)))............)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))....((.....))......(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of tRNA-Thr bound to Codon ACC-C on the Ribosome; 23S rRNA 4tub RB 120 3.6 RF00001 URS00005F2F4B_300852 25352689 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> (((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).))))))))))) Crystal structure of tRNA-Thr bound to Codon ACC-C on the Ribosome; 5S rRNA 4tub XA 1500 3.6 RF00177,RF01959,RF01960 URS000080E226_300852 25352689 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggggacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<...>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<<....>>>>..>>>>>>>>.<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((.(.).)))))))).)))))......(((......((((((((..((...(((((((.(((((....((((........)))).....)))))....((((.(.(((....))).).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((((..(((((((....)))))))...((((....))))..))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((.......(((.....)))......)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Crystal structure of tRNA-Thr bound to Codon ACC-C on the Ribosome; 16S rRNA 4tub XV 77 3.6 RF00005 URS000041AF00_1403831 25352689 0030533 0006412 1403831 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of tRNA-Thr bound to Codon ACC-C on the Ribosome; P-site tRNA f-Met 4tub XX 10 3.6 25352689 32630 aaugacccaa .......... .......... Crystal structure of tRNA-Thr bound to Codon ACC-C on the Ribosome; messenger RNA 4tub XY 16 3.6 URS00008116B9_1403831 25352689 1403831 acccuugguaagggug <<<<<.....>>>>>. ((((.......)))). Crystal structure of tRNA-Thr bound to Codon ACC-C on the Ribosome; A-site tRNA Thr 4tub YA 2882 3.6 RF02540,RF02541,RF00002 URS00001698E8_300852 25352689 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<..>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<.<.........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>>.>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<<<<<<<<...<<.......>>...>>>>>>>..>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<<.....>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....(())...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((...((((((......)))).))...))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......(((((.((...(((.........)))...)).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((.{{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((.((.(((((((((.(.........(((((...((......((((((((....))))))))...)).............)))))).))))))))).)).)))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}}))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(..(((.....))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal structure of tRNA-Thr bound to Codon ACC-C on the Ribosome; 23S rRNA 4tub YB 120 3.6 RF00001 URS00005F2F4B_300852 25352689 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> (((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).))))))))))) Crystal structure of tRNA-Thr bound to Codon ACC-C on the Ribosome; 5S rRNA 4tuc QA 1500 3.6 RF00177,RF01959,RF01960 URS000080E226_300852 25352689 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggggucuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<...<..<<<.<<<..<<<..<<.<<<<<<<<<...>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>...>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<<....>>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((((..(((((((....)))))))....(((....)))...))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((.......(((.....)))......))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Crystal structure of ASL-SufJ bound to Codon ACC-A on the Ribosome; 16S rRNA 4tuc QV 77 3.6 RF00005 URS000041AF00_1403831 25352689 0030533 0006412 1403831 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of ASL-SufJ bound to Codon ACC-A on the Ribosome; P-site tRNA fMet 4tuc QX 11 3.6 25352689 32630 aaugaccaaaa ........... ........... Crystal structure of ASL-SufJ bound to Codon ACC-A on the Ribosome; messenger RNA 4tuc QY 15 3.6 URS00008116C4_32630 25352689 32630 ccccuugguaagggu <<<........>>>. (((........))). Crystal structure of ASL-SufJ bound to Codon ACC-A on the Ribosome; A-site ASL-SufJ 4tuc RA 2882 3.6 RF02540,RF02541,RF00002 URS00001698E8_300852 25352689 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>....<<<<<.....<......>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<..>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<.]]]].>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<<.....>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[[)))...].((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...((((((((.....))))))))....{.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).))))....(((((((((.[.....)))))))))....}.(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...........)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((...(((((........))).))...))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......(((((.((....((.........))....)).........((......))...)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........(((((..(((......(((((.((....)).)))))...)))............)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(..(((.....))).....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))...)))) Crystal structure of ASL-SufJ bound to Codon ACC-A on the Ribosome; 23S rRNA 4tuc RB 120 3.6 RF00001 URS00005F2F4B_300852 25352689 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> (((((((((((....((((((((....(.(((((...(.....)...))))..).)...)))))).))(((.......((.(((((....))))).)).......))).))))))))))) Crystal structure of ASL-SufJ bound to Codon ACC-A on the Ribosome; 5S rRNA 4tuc XA 1500 3.6 RF00177,RF01959,RF01960 URS000080E226_300852 25352689 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggggacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<...>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<<....>>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((.(.).)))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((((..(((((((....)))))))...(((......)))..))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((.......(((.....)))......))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Crystal structure of ASL-SufJ bound to Codon ACC-A on the Ribosome; 16S rRNA 4tuc XV 77 3.6 RF00005 URS000041AF00_1403831 25352689 0030533 0006412 1403831 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of ASL-SufJ bound to Codon ACC-A on the Ribosome; P-site tRNA fMet 4tuc XX 10 3.6 25352689 32630 aaugaccaaa .......... .......... Crystal structure of ASL-SufJ bound to Codon ACC-A on the Ribosome; messenger RNA 4tuc XY 15 3.6 URS00008116C4_32630 25352689 32630 ccccuugguaagggu <<<........>>>. (((........))). Crystal structure of ASL-SufJ bound to Codon ACC-A on the Ribosome; A-site ASL-SufJ 4tuc YA 2882 3.6 RF02540,RF02541,RF00002 URS00001698E8_300852 25352689 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>....<<<<<.....<......>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<..>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<<<<<<<<...<<.......>>...>>>>>>>..>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....(..)...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((...((((((......)))).))...)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......(((((.((...(((.........)))...)).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........(((((..(((......((((((((....))))))))...)))............)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(..(((.....))).....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))...)))) Crystal structure of ASL-SufJ bound to Codon ACC-A on the Ribosome; 23S rRNA 4tuc YB 120 3.6 RF00001 URS00005F2F4B_300852 25352689 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> (((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).))))))))))) Crystal structure of ASL-SufJ bound to Codon ACC-A on the Ribosome; 5S rRNA 4tud QA 1500 3.6 RF00177,RF01959,RF01960 URS000080E226_300852 25352689 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggggucuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<...>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<<....>>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((((..(((((((....)))))))...((((....))))..))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((.......(((.....)))......))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Crystal structure of ASL-SufJ bound to Codon ACC-C on the Ribosome; 16S rRNA 4tud QV 77 3.6 RF00005 URS000041AF00_1403831 25352689 0030533 0006412 1403831 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of ASL-SufJ bound to Codon ACC-C on the Ribosome; P-site tRNA-fMet 4tud QY 15 3.6 URS00008116C4_32630 25352689 32630 ccccuugguaagggu <<<........>>>. (((........))). Crystal structure of ASL-SufJ bound to Codon ACC-C on the Ribosome; A-site ASL-SufJ 4tud RA 2882 3.6 RF02540,RF02541,RF00002 URS00001698E8_300852 25352689 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>....<<<<<.....<......>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<..>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<<..<<.......>>>..>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<<.....>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[[)))...].((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....(())...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((...((((((......)))).))...))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......(((((.((....((.........))....)).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........(((((..(((......((((((((....))))))))...)))............)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(...((.....))......(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))...)))) Crystal structure of ASL-SufJ bound to Codon ACC-C on the Ribosome; 23S rRNA 4tud RB 120 3.6 RF00001 URS00005F2F4B_300852 25352689 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> (((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).))))))))))) Crystal structure of ASL-SufJ bound to Codon ACC-C on the Ribosome; 5S rRNA 4tud XA 1500 3.6 RF00177,RF01959,RF01960 URS000080E226_300852 25352689 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggggacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<...>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<<....>>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((.(.).)))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).(((.(...))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((((..(((((((....)))))))...((((....))))..))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((.......(((.....)))......))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Crystal structure of ASL-SufJ bound to Codon ACC-C on the Ribosome; 16S rRNA 4tud XV 77 3.6 RF00005 URS000041AF00_1403831 25352689 0030533 0006412 1403831 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of ASL-SufJ bound to Codon ACC-C on the Ribosome; P-site tRNA-fMet 4tud XY 15 3.6 URS00008116C4_32630 25352689 32630 ccccuugguaagggu <<<........>>>. (((........))). Crystal structure of ASL-SufJ bound to Codon ACC-C on the Ribosome; A-site ASL-SufJ 4tud YA 2882 3.6 RF02540,RF02541,RF00002 URS00001698E8_300852 25352689 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<..>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<.<.........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>>.>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<<<<<<<<...<<.......>>...>>>>>>>..>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<<.....>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....(())...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((...((((((......)))).))...))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......(((((.((...(((.........)))...)).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........(((((..(((......((((((((....))))))))...)))............)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(..(((.....))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal structure of ASL-SufJ bound to Codon ACC-C on the Ribosome; 23S rRNA 4tud YB 120 3.6 RF00001 URS00005F2F4B_300852 25352689 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> (((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).))))))))))) Crystal structure of ASL-SufJ bound to Codon ACC-C on the Ribosome; 5S rRNA 4tue QA 1500 3.5 RF00177,RF01959,RF01960 URS000080E226_300852 25352689 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggggucuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<...>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<<....>>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((((..(((((((....)))))))...((((....))))..))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((.......(((.....)))......))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Crystal structure of ASL-SufJ bound to Codon ACC-U on the Ribosome; 16S rRNA 4tue QV 77 3.5 RF00005 URS000041AF00_181333 25352689 0030533 0006412 181333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of ASL-SufJ bound to Codon ACC-U on the Ribosome; P-site tRNA-fMet 4tue QY 15 3.5 URS00008116C4_32630 25352689 32630 ccccuugguaagggu <<<........>>>. (((........))). Crystal structure of ASL-SufJ bound to Codon ACC-U on the Ribosome; A-site ASL-SufJ 4tue RA 2882 3.5 RF02540,RF02541,RF00002 URS00001698E8_300852 25352689 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>....<<<<<.....<......>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<..>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>......>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<<.....>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[[)))...].((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....(())...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((...((((((......)))).))...))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......(((((.((....(((.......)))....)).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........(((((...((......((((((((....))))))))...)).............)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(...((.....))......(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal structure of ASL-SufJ bound to Codon ACC-U on the Ribosome; 23S rRNA 4tue RB 120 3.5 RF00001 URS00005F2F4B_300852 25352689 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> (((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).))))))))))) Crystal structure of ASL-SufJ bound to Codon ACC-U on the Ribosome; 5S rRNA 4tue XA 1500 3.5 RF00177,RF01959,RF01960 URS000080E226_300852 25352689 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggggacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<...>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<<....>>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((.(.).)))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).(((.(...))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((((..(((((((....)))))))...((((....))))..))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((.......(((.....)))......)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Crystal structure of ASL-SufJ bound to Codon ACC-U on the Ribosome; 16S rRNA 4tue XV 77 3.5 RF00005 URS000041AF00_181333 25352689 0030533 0006412 181333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of ASL-SufJ bound to Codon ACC-U on the Ribosome; P-site tRNA-fMet 4tue XX 11 3.5 25352689 32630 aaaaugaccua ........... ........... Crystal structure of ASL-SufJ bound to Codon ACC-U on the Ribosome; messenger RNA 4tue XY 15 3.5 URS00008116C4_32630 25352689 32630 ccccuugguaagggu <<<........>>>. (((........))). Crystal structure of ASL-SufJ bound to Codon ACC-U on the Ribosome; A-site ASL-SufJ 4tue YA 2882 3.5 RF02540,RF02541,RF00002 URS00001698E8_300852 25352689 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<..>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<.<.........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>>.>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<<.....>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....(())...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((...((.(((......)))..))...)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......(((((.((...(((.........)))...)).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........(((((...((......((((((((....))))))))...)).............)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(...((.....))......(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal structure of ASL-SufJ bound to Codon ACC-U on the Ribosome; 23S rRNA 4tue YB 120 3.5 RF00001 URS00005F2F4B_300852 25352689 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> (((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).))))))))))) Crystal structure of ASL-SufJ bound to Codon ACC-U on the Ribosome; 5S rRNA 4tzp B 70 8.503 RF00005 URS000080DE51_1423 25185828,23892783 0030533 0006412 1423 gaguaguucagugguagaacaccaccuugccaaggugggggucgcggguucgaaucccgucucgggcccc <<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>><<<.>>> (((..((((....[..)))).(((((.......))))).....(((((..]....))))))))(((.))) As Grown, Untreated Co-crystals of the Ternary Complex Containing a T-box Stem I RNA, its cognate tRNAGly, and B. subtilis YbxF protein; engineered tRNA 4tzp C 102 8.503 RF00230 URS000080DF58_182710 25185828,23892783 0000049 182710 gggugcgaugagaagaagaguauuaaggauuuacuaugauuagcgacucuaggauagugaaagcuagaggauaguaaccuuaagaaggcacuucgagcaccc <<<<<<.....<<<<.......<<<<<<..<<<<<<<.........<<<<<<...........>>>>>>.>>>>>>>>>>>>>.......>>>>..>>>>>> (((.((.....((((.......((.(((...((((((......[..((((((..........])))))).)))))).))).)).......))))..)).))) As Grown, Untreated Co-crystals of the Ternary Complex Containing a T-box Stem I RNA, its cognate tRNAGly, and B. subtilis YbxF protein; glyQ T-box Stem I 4tzp E 75 8.503 RF00005 URS000080DE51_1423 25185828,23892783 0030533 0006412 1423 gaguaguucagugguagaacaccaccuugccaaggugggggucgcggguucgaaucccgucucgggcgaaagccc <<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>><<<<....>>>> (((..((((....[..)))).(((((.......))))).....(((((..]....))))))))((((....)))) As Grown, Untreated Co-crystals of the Ternary Complex Containing a T-box Stem I RNA, its cognate tRNAGly, and B. subtilis YbxF protein; engineered tRNA 4tzp F 102 8.503 RF00230 URS000080DF58_182710 25185828,23892783 0000049 182710 gggugcgaugagaagaagaguauuaaggauuuacuaugauuagcgacucuaggauagugaaagcuagaggauaguaaccuuaagaaggcacuucgagcaccc <<<<<<.....<<<<.......<<<<<<..<<<<<<<.........<<<<<<...........>>>>>>.>>>>>>>>>>>>>.......>>>>..>>>>>> ((((((.....((((.......((.(((...((((((......[..((((((..........])))))).)))))).))).)).......))))..)))))) As Grown, Untreated Co-crystals of the Ternary Complex Containing a T-box Stem I RNA, its cognate tRNAGly, and B. subtilis YbxF protein; glyQ T-box Stem I 4tzv B 75 5.03 RF00005 URS000080DE51_1423 25185828,23892783 0030533 0006412 1423 gaguaguucagugguagaacaccaccuugccaaggugggggucgcggguucgaaucccgucucgggcgaaagccc <<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>><<<<....>>>> (((..((((....[..)))).(((((.......))))).....(((((..]....))))))))((((....)))) Co-crystals of the Ternary Complex Containing a T-box Stem I RNA, its Cognate tRNAGly, and B. subtilis YbxF protein, treated by removing lithium sulfate post crystallization; engineered tRNA 4tzv C 102 5.03 RF00230 URS000080DF58_221109 25185828,23892783 0000049 221109 gggugcgaugagaagaagaguauuaaggauuuacuaugauuagcgacucuaggauagugaaagcuagaggauaguaaccuuaagaaggcacuucgagcaccc <<<<<<.....<<<<.......<<<<<<..<<<<<<<.........<<<<<<...........>>>>>>.>>>>>>>>>>>>>.......>>>>..>>>>>> ((((((.....((((.......(((.((..((((((.......[..((((((..........]))))))..)))))))).))).......))))..)))))) Co-crystals of the Ternary Complex Containing a T-box Stem I RNA, its Cognate tRNAGly, and B. subtilis YbxF protein, treated by removing lithium sulfate post crystallization; T-box stem I 4tzw B 75 4.671 RF00005 URS000080DE51_1423 25185828,23892783 0030533 0006412 1423 gaguaguucagugguagaacaccaccuugccaaggugggggucgcggguucgaaucccgucucgggcgaaagccc <<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>><<<<....>>>> (((..((((....[..)))).(((((.......))))).....(((((..]....))))))))((((....)))) Co-crystals of the Ternary Complex Containing a T-box Stem I RNA, its Cognate tRNAGly, and B. subtilis YbxF protein, treated by removing lithium sulfate and replacing Mg2+ with Sr2+ post crystallization; engineered tRNA 4tzw C 102 4.671 RF00230 URS000080DF58_221109 25185828,23892783 0000049 221109 gggugcgaugagaagaagaguauuaaggauuuacuaugauuagcgacucuaggauagugaaagcuagaggauaguaaccuuaagaaggcacuucgagcaccc <<<<<<.....<<<<.......<<<<<<..<<<<<<<.........<<<<<<...........>>>>>>.>>>>>>>>>>>>>.......>>>>..>>>>>> ((((((.....((((.......((((((..(((((((......[..((((((..........])))))).))))))))))))).......))))..)))))) Co-crystals of the Ternary Complex Containing a T-box Stem I RNA, its Cognate tRNAGly, and B. subtilis YbxF protein, treated by removing lithium sulfate and replacing Mg2+ with Sr2+ post crystallization; T-box Stem I 4tzz B 75 3.64 RF00005 URS000080DE51_1423 25185828 0030533 0006412 1423 gaguaguucagugguagaacaccaccuugccaaggugggggucgcggguucgaaucccgucucgggcgaaagccc <<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>><<<<....>>>> (((..((((....[..)))).(((((.......))))).....(((((..]....))))))))((((....)))) Co-crystals of the Ternary Complex Containing a T-box Stem I RNA, its Cognate tRNAGly, and B. subtilis YbxF protein, treated by removing lithium sulfate and increasing PEG3350 concentration from 20% to 45% post crystallization; engineered tRNAGly 4tzz C 102 3.64 RF00230 URS000080DF58_182710 25185828 0000049 182710 gggugcgaugagaagaagaguauuaaggauuuacuaugauuagcgacucuaggauagugaaagcuagaggauaguaaccuuaagaaggcacuucgagcaccc <<<<<<.....<<<<.......<<<<<<..<<<<<<<.........<<<<<<...........>>>>>>.>>>>>>>>>>>>>.......>>>>..>>>>>> ((((((.....((((.......((((((..(((((((......[..((((((..........])))))).))))))))))))).......))))..)))))) Co-crystals of the Ternary Complex Containing a T-box Stem I RNA, its Cognate tRNAGly, and B. subtilis YbxF protein, treated by removing lithium sulfate and increasing PEG3350 concentration from 20% to 45% post crystallization; T-box Stem I RNA 4tzz E 75 3.64 RF00005 URS000080DE51_1423 25185828 0030533 0006412 1423 gaguaguucagugguagaacaccaccuugccaaggugggggucgcggguucgaaucccgucucgggcgaaagccc <<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>><<<<....>>>> (((..((((....[..)))).(((((.......))))).....(((((..]....))))))))((((....)))) Co-crystals of the Ternary Complex Containing a T-box Stem I RNA, its Cognate tRNAGly, and B. subtilis YbxF protein, treated by removing lithium sulfate and increasing PEG3350 concentration from 20% to 45% post crystallization; engineered tRNAGly 4tzz F 102 3.64 RF00230 URS000080DF58_182710 25185828 0000049 182710 gggugcgaugagaagaagaguauuaaggauuuacuaugauuagcgacucuaggauagugaaagcuagaggauaguaaccuuaagaaggcacuucgagcaccc <<<<<<.....<<<<.......<<<<<<..<<<<<<<.........<<<<<<...........>>>>>>.>>>>>>>>>>>>>.......>>>>..>>>>>> ((((((.....((((.......((...(..(((((((......[..((((((..........])))))).))))))))...)).......))))..)))))) Co-crystals of the Ternary Complex Containing a T-box Stem I RNA, its Cognate tRNAGly, and B. subtilis YbxF protein, treated by removing lithium sulfate and increasing PEG3350 concentration from 20% to 45% post crystallization; T-box Stem I RNA 4tzz H 75 3.64 RF00005 URS000080DE51_1423 25185828 0030533 0006412 1423 gaguaguucagugguagaacaccaccuugccaaggugggggucgcggguucgaaucccgucucgggcgaaagccc <<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>><<<<....>>>> (((..((((....[..)))).(((((.......))))).....(((((..]....))))))))((((....)))) Co-crystals of the Ternary Complex Containing a T-box Stem I RNA, its Cognate tRNAGly, and B. subtilis YbxF protein, treated by removing lithium sulfate and increasing PEG3350 concentration from 20% to 45% post crystallization; engineered tRNAGly 4tzz I 102 3.64 RF00230 URS000080DF58_182710 25185828 0000049 182710 gggugcgaugagaagaagaguauuaaggauuuacuaugauuagcgacucuaggauagugaaagcuagaggauaguaaccuuaagaaggcacuucgagcaccc <<<<<<.....<<<<.......<<<<<<..<<<<<<<.........<<<<<<...........>>>>>>.>>>>>>>>>>>>>.......>>>>..>>>>>> ((((((.....((((.......((((((..((((((.......[..((((((..........]))))))..)))))))))))).......))))..)))))) Co-crystals of the Ternary Complex Containing a T-box Stem I RNA, its Cognate tRNAGly, and B. subtilis YbxF protein, treated by removing lithium sulfate and increasing PEG3350 concentration from 20% to 45% post crystallization; T-box Stem I RNA 4tzz K 75 3.64 RF00005 URS000080DE51_1423 25185828 0030533 0006412 1423 gaguaguucagugguagaacaccaccuugccaaggugggggucgcggguucgaaucccgucucgggcgaaagccc <<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>><<<<....>>>> (((..((((....[..)))).(((((.......))))).....(((((..]....))))))))((((....)))) Co-crystals of the Ternary Complex Containing a T-box Stem I RNA, its Cognate tRNAGly, and B. subtilis YbxF protein, treated by removing lithium sulfate and increasing PEG3350 concentration from 20% to 45% post crystallization; engineered tRNAGly 4tzz L 102 3.64 RF00230 URS000080DF58_182710 25185828 0000049 182710 gggugcgaugagaagaagaguauuaaggauuuacuaugauuagcgacucuaggauagugaaagcuagaggauaguaaccuuaagaaggcacuucgagcaccc <<<<<<.....<<<<.......<<<<<<..<<<<<<<.........<<<<<<...........>>>>>>.>>>>>>>>>>>>>.......>>>>..>>>>>> ((((((.....((((.......((((((..(((((((......[..(.((((..........])))).).))))))))))))).......))))..)))))) Co-crystals of the Ternary Complex Containing a T-box Stem I RNA, its Cognate tRNAGly, and B. subtilis YbxF protein, treated by removing lithium sulfate and increasing PEG3350 concentration from 20% to 45% post crystallization; T-box Stem I RNA 4u1u AA 1538 2.95 RF00177,RF01959,RF01960 URS000080DDC0_1110693 24957822 0003735 0005840 1110693 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccucc .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<...<<<<<.<<........>>.>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<<..>>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<.<......<<........>>..........<<<<<<<.......<<<<<<..<<<<<<<....>>>>>>>.............>>>>>.>..<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<...<<<.....>>>.>.....>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>..>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>........... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((..(.(....).)..)).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(..(.((((((((.......)))))))).)...)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((.((...(...(((((((..(((((((....)))))))...((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).))))).....)).)))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((..((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.......... Crystal structure of the E. coli ribosome bound to quinupristin.; 16S rRNA 4u1u BA 2897 2.95 RF02540,RF02541 URS000080E25C_1110693 24957822 0003735 0005840 1110693 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<.>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<....<...........>....>>........<<........>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<..<......>..>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>.>......>>>>>>>>..>>>>>.<<<<<.......>>>>>.........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<...<<......<<<.<<<<....>>>>.>>>...>>.............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((((((.)))).))...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((..((....(.........)....))......(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((..........))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]]((((((((((.((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...)).....)))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((..(((.(.........(((((...((........((.(........).)).....)).............)))))).)))..)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Crystal structure of the E. coli ribosome bound to quinupristin.; 23S rRNA 4u1u BB 119 2.95 RF00001 URS000080E133_1110693 24957822 0003735 0005840 1110693 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>> ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))) Crystal structure of the E. coli ribosome bound to quinupristin.; 5S rRNA 4u1u CA 1539 2.95 RF00177,RF01959,RF01960 URS000080DDC0_1110693 24957822 0003735 0005840 1110693 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<<....>>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<...<....>.>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<.<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<<..<<<.....>>>>>.....>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>..>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((((....))))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((...(..(...(((((((...((((((....))))))..............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)...)))...)).)))))))).(...(((((((.....(((..((....((....))....))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Crystal structure of the E. coli ribosome bound to quinupristin.; 16S rRNA 4u1u DA 2897 2.95 RF02540,RF02541 URS000080E25C_1110693 24957822 0003735 0005840 1110693 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<.>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<...........>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<.<<....>>.>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<..<<....>>...>>>>>..>....>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>...>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))((((.((....)).)))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((((((.)))).))...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(.(...(............)..).)........(.(......).)..)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((.(.(......).).))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(...((((....))))....))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((((.(.........(((((..(((......((((((((....))))))))...)))............)))))).)))).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Crystal structure of the E. coli ribosome bound to quinupristin.; 23S rRNA 4u1u DB 118 2.95 RF00001 URS000080E133_1110693 24957822 0003735 0005840 1110693 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))). Crystal structure of the E. coli ribosome bound to quinupristin.; 5S rRNA 4u1v AA 1538 3.0 RF00177,RF01959,RF01960 URS000080DDC0_1110693 24957822 0003735 0005840 1110693 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccucc .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<.<<........>>.>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<.......<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>..<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<<..<<<.....>>>>>.....>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>........... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((...(.(....).)...).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(..(.((((((((.......)))))))).)...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))....(....)...))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((.(...((..(((.....)))))....).)))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...((((((......(((..((...(((....)))...))....)))......))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.......... Crystal structure of the E. coli ribosome bound to linopristin.; 16S rRNA 4u1v BA 2897 3.0 RF02540,RF02541 URS000080E25C_1110693 24957822 0003735 0005840 1110693 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<.>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<....<...........>....>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<..<......>..>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>..>.....>>>>>>>>..>>>>>.<<<<<.......>>>>>.........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<.............<<<...<<......<<<.<<<<....>>>>.>>>...>>.............>>>....>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((((...))).))...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((..((....(.........)....))......(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((..........))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..))))).((((.........)))).........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((((((.((.((((.(..........((((...((........(..((......))..).....)).............)))).).)))).)).))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Crystal structure of the E. coli ribosome bound to linopristin.; 23S rRNA 4u1v BB 119 3.0 RF00001 URS000080E133_1110693 24957822 0003735 0005840 1110693 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>> ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))) Crystal structure of the E. coli ribosome bound to linopristin.; 5S rRNA 4u1v CA 1539 3.0 RF00177,RF01959,RF01960 URS000080DDC0_1110693 24957822 0003735 0005840 1110693 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<<....>>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<.......<<<....>>>......>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<.<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<..<<<<<<....<...<<<.....>>>.>.....>>>>>>.....<<<<<.....>>>>>.........>>>.........>>>...>>>>>>>>>...>>>>>>>...>..>>>>>>>>.....<<<<<<<.....<<<..<....<<<....>>>....>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((((....))))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..........)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((.(.........)))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(..(.((((((((.......)))))))).)...)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...(((((((.....((((((....((........)).......))))))............((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((...(..(...((((.((...((((((....))))))..............)).)).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)...)))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Crystal structure of the E. coli ribosome bound to linopristin.; 16S rRNA 4u1v DA 2897 3.0 RF02540,RF02541 URS000080E25C_1110693 24957822 0003735 0005840 1110693 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<.>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<...........>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<.<......>.>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>>...<<<<<....>>>>>....>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<..<<....>>...>>>>>..>....>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<..<<<.<<<<<.<<<<<<<<<<<.<<<............<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>...>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>...>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))((((..(....)..)))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((.(((..[......))).))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((((((.)))).))...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(.(...((.........).)..).)........(.(......).)..)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((.(.(......).).))))....))))))(.(((((...(((......(((.((((....)))).)))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((.....(((..(((..((((((((((((...{{{.).)))))).(..((((...((((((((((((.((.....))))))))))..))))..[))))...).(...((((....))))....))))))...)))...))).(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((((.(.........(((((..(((......((((((((....))))))))...)))............)))))).)))).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Crystal structure of the E. coli ribosome bound to linopristin.; 23S rRNA 4u1v DB 118 3.0 RF00001 URS000080E133_1110693 24957822 0003735 0005840 1110693 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))). Crystal structure of the E. coli ribosome bound to linopristin.; 5S rRNA 4u20 AA 1538 2.9 RF00177,RF01959,RF01960 URS000080DDC0_1110693 24957822 0003735 0005840 1110693 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccucc .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<...<<<<<.<<........>>.>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<.......<<<<<<..<<<<<<<....>>>>>>>.............>>>>>.>..<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<...<<<.....>>>.>.....>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>........... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((...(.(....).)...).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(..(.((((((((.......)))))))).)...)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........((((.....(...(((((((..(((((((....)))))))....(....)...))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))......).)))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.......... Crystal structure of the E. coli ribosome bound to flopristin.; 16S rRNA 4u20 BA 2897 2.9 RF02540,RF02541 URS000080E25C_1110693 24957822 0003735 0005840 1110693 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<.>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<....<...........>....>>........<<........>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<..<......>..>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>..>.....>>>>>>>>..>>>>>.<<<<<.......>>>>>.........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<...<<......<<<.<<<<....>>>>.>>>...>>.............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((((((.)))).))...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((..((....(.........)....))......(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((..........))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]]((((((((((.((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...)).....)))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..((.((((..(((........(((((..((....))...)))))........)))))))...))))).((((.........)))).........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((((.(.........((.((...((........((.(........).)).....)).............)).))).)))).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Crystal structure of the E. coli ribosome bound to flopristin.; 23S rRNA 4u20 BB 119 2.9 RF00001 URS000080E133_1110693 24957822 0003735 0005840 1110693 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>> ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))) Crystal structure of the E. coli ribosome bound to flopristin.; 5S rRNA 4u20 CA 1539 2.9 RF00177,RF01959,RF01960 URS000080DDC0_1110693 24957822 0003735 0005840 1110693 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<...<<<<<<<<<<....>>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<.<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<...<<<.....>>>.>.....>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>..>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((((....))))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..........)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(...(((((((((.......)))))))).)...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((...(..(...(((((((...((((((....))))))..............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)...)))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Crystal structure of the E. coli ribosome bound to flopristin.; 16S rRNA 4u20 DA 2897 2.9 RF02540,RF02541 URS000080E25C_1110693 24957822 0003735 0005840 1110693 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<.>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<...........>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<.<......>.>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<....<....>.....>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<..<<....>>...>>>>>..>....>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>...>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))((((.((....)).)))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...((..((((...((((((.)))).))...))))..))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(.(...(............)..).)........(.(......).)..)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((.(.(......).).))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(...((((....))))....))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((((.(.........(((((..(((......((((((((....))))))))...)))............)))))).)))).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Crystal structure of the E. coli ribosome bound to flopristin.; 23S rRNA 4u20 DB 118 2.9 RF00001 URS000080E133_1110693 24957822 0003735 0005840 1110693 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))). Crystal structure of the E. coli ribosome bound to flopristin.; 5S rRNA 4u24 AA 1538 2.9 RF00177,RF01959,RF01960 URS000080DDC0_1110693 24957822 0003735 0005840 1110693 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccucc .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<.<<<<....>>>.>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<.<......<<........>>..........<<<<<<<......<<<<<<<....<<<<<....>>>>>...............>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<<..<<<.....>>>>>.....>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>..>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>........... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((...(........)...).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((...(.....))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(..(.((((((((.......)))))))).)...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((.(.((((((((((......((((((.....))))))....))))))))..))).)))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(.(..(....)..).).....(....)...))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.......... Crystal structure of the E. coli ribosome bound to dalfopristin.; 16S rRNA 4u24 BA 2897 2.9 RF02540,RF02541 URS000080E25C_1110693 24957822 0003735 0005840 1110693 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<<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<...>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<....<...........>....>>........<<........>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<.<......>.>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>>.<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>.<..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>..>.....>>>>>>>>..>>>>>.<<<<<.......>>>>>.........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<.<..<<...<<..............<<...........<...<<<......>>>...>..................>>.....>>...>>..>.>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((.(....).))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((((((.)))).))...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(.(.........))...))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((..........))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..))))).((((.........)))).........((.(......).(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((........................(.((.................................................)).)...............))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Crystal structure of the E. coli ribosome bound to dalfopristin.; 23S rRNA 4u24 BB 119 2.9 RF00001 URS000080E133_1110693 24957822 0003735 0005840 1110693 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>> ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))) Crystal structure of the E. coli ribosome bound to dalfopristin.; 5S rRNA 4u24 CA 1539 2.9 RF00177,RF01959,RF01960 URS000080DDC0_1110693 24957822 0003735 0005840 1110693 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<......>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<........<<........>>..........<<<<<<<.......<<<<<<..<<<<<<......>>>>>>...<......>..>>>>>.>..<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<...<<<.....>>>.>.....>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>......>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((.(.....)))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....(((.((..........)).))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((.(.........)))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(..(.((((((((.......)))))))).)...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........((((..(..(...(((..((..((.(.((....)).).)).............))..).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((.(...((...((.....)).))....).)))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)..))))...)).)))))))).(...(((((((.....(((..((....((....))....))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Crystal structure of the E. coli ribosome bound to dalfopristin.; 16S rRNA 4u24 DA 2897 2.9 RF02540,RF02541 URS000080E25C_1110693 24957822 0003735 0005840 1110693 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<.<<.[..(((.>>......<<<<<<<..<<.)))..]..>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<...>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<.............>...>>.........<<......>>...>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>>....<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>.....<..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<..<<....>>...>>>>>..>....>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<..<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<...<<......<<<<<<<<....>>>>>>>>...>>.............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>...>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((......((..((..(((((((((.......(((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)).....(((....)))((((..(....)..)))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((..(((......((((((((((.((.(((...(((((......)))))[[(...).(((.....]])))...)))...)).))))))))))...)))....)....((((.(((..[......))).))))......(((((].[[[[)))))..)))......)).)))))...))...............((....))....))......(..((((.....))))............)......)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((.(((..(((...((.....))...)))...((....))..((((.....)))).....))).)))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((..(...)...))...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((.((..(((.....{.(((((.(.(...(............)..).)..........(......)....)))))...)))..)).)).))...........]]].)...))))))))))...)))))))((((.(..........).))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((.....(((..((..(((((((...((.....)).))))))....[[((..(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).)))))).(..(((....((((((((((((.((.....))))))))))..))))..[.)))...).(..(((((....)))))...))))))...)))...))))(..).....))))...))....)))))))))))..)).))).....((......)).)))..((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........((.((..((....))...)).))........))))))))..)))))(((((.........)))))........((.(......).(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((((.(.........(((((...((......((((((((....))))))))...)).............)))))).)))).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(..((((.....)))).(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Crystal structure of the E. coli ribosome bound to dalfopristin.; 23S rRNA 4u24 DB 118 2.9 RF00001 URS000080E133_1110693 24957822 0003735 0005840 1110693 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (.(((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))).). Crystal structure of the E. coli ribosome bound to dalfopristin.; 5S rRNA 4u25 AA 1538 2.9 RF00177,RF01959,RF01960 URS000080DDC0_1110693 24957822 0003735 0005840 1110693 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccucc .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<.<<........>.>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<<..<<<.....>>>>>.....>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>........... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((....(....)....)).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(..(.((((((((.......)))))))).)...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((.....((.(....).)).......(....)...))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....))))))))..)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.......... Crystal structure of the E. coli ribosome bound to virginiamycin M1.; 16S rRNA 4u25 BA 2897 2.9 RF02540,RF02541 URS000080E25C_1110693 24957822 0003735 0005840 1110693 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<...>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<.....................>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<..<......>..>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>..>.....>>>>>>>>..>>>>>.<<<<<.......>>>>>.........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<.<<.<<<<.............<<<...<<......<<<.<<<<....>>>>.>>>...>>.............>>>....>>>>.>>.>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((((...))).))...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((..((..(.(.........))...))......(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((..........))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))..(((.........)))..........((.(......).(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((.(.(.((.(.(...............((....(.............................)..............))......).).)).).).))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Crystal structure of the E. coli ribosome bound to virginiamycin M1.; 23S rRNA 4u25 BB 119 2.9 RF00001 URS000080E133_1110693 24957822 0003735 0005840 1110693 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>> ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))) Crystal structure of the E. coli ribosome bound to virginiamycin M1.; 5S rRNA 4u25 CA 1539 2.9 RF00177,RF01959,RF01960 URS000080DDC0_1110693 24957822 0003735 0005840 1110693 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<<....>>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<.......<<<....>>>......>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<........<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<...<<<.....>>>.>.....>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>......>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((.(.....)))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..........)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(...(((((((((.......)))))))).)...)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...(((((((.....(((((((...((........))......)))))))............((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((...(..(...((((.((...(.(.((....)).).)..............)).)).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((...((.....)).))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)...))))..)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Crystal structure of the E. coli ribosome bound to virginiamycin M1.; 16S rRNA 4u25 DA 2897 2.9 RF02540,RF02541 URS000080E25C_1110693 24957822 0003735 0005840 1110693 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<.<<.[..(((.>>......<<<<<<<..<<.)))..]..>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<.>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<...........>>...>>.........<<......>>...>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<.<<....>>.>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><...<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>....><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<..<<....>>...>>>>>..>....>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>...>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))((((..(....)..)))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((.(((.(((...(((((......)))))[[(...).(((.....]])))...)))...))).)))))))))...))))...)....((((.(((..[......))).))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...((..((((...((((((.)))).))...))))..))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(.(...((.........).)..).)..........(......)....)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((.(.(......).).))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).)))))).(..((((...((((((((((((.((.....))))))))))..))))..[))))...).(...((((....))))....))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((......{........)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((((.(.........(((((...((......((((((((....))))))))...)).............)))))).)))).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Crystal structure of the E. coli ribosome bound to virginiamycin M1.; 23S rRNA 4u25 DB 118 2.9 RF00001 URS000080E133_1110693 24957822 0003735 0005840 1110693 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))). Crystal structure of the E. coli ribosome bound to virginiamycin M1.; 5S rRNA 4u26 AA 1538 2.8 RF00177,RF01959,RF01960 URS000080DDC0_1110693 24957822 0003735 0005840 1110693 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccucc .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<.<<<<....>>>.>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<.<......<<........>>..........<<<<<<<......<<<<<<<....<<<<<....>>>>>...............>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<<..<<<.....>>>>>.....>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>..>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>........... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((...(........)...).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((...(.....))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(..(.((((((((.......)))))))).)...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((.(.((((((((((......((((((.....))))))....))))))))..))).)))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((..(((...(.(..(....)..).).....(....)...)))...))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.......... Crystal structure of the E. coli ribosome bound to dalfopristin and quinupristin.; 16S rRNA 4u26 BA 2897 2.8 RF02540,RF02541 URS000080E25C_1110693 24957822 0003735 0005840 1110693 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<...>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<....<...........>....>>........<<........>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<.<......>.>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>..>.....>>>>>>>>..>>>>>.<<<<<.......>>>>>.........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<.<..<<...<<..............<<...........<...<<<<....>>>>...>..................>>.....>>...>>..>.>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((.(....).))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((((...))).))...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(.(.........))...))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((..........))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..))))).(.((.........)).).........((.(......).(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((........................(.((.................................................)).)...............))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Crystal structure of the E. coli ribosome bound to dalfopristin and quinupristin.; 23S rRNA 4u26 BB 119 2.8 RF00001 URS000080E133_1110693 24957822 0003735 0005840 1110693 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>> ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))) Crystal structure of the E. coli ribosome bound to dalfopristin and quinupristin.; 5S rRNA 4u26 CA 1539 2.8 RF00177,RF01959,RF01960 URS000080DDC0_1110693 24957822 0003735 0005840 1110693 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<......>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<....<.<<<<<<.....>>>>>>.>..>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<........<<........>>..........<<<<<<<.......<<<<<<..<<<<<<......>>>>>>...<......>..>>>>>.>..<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<...<<<.....>>>.>.....>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>......>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((.(.....)))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....(((.((..........)).))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((.(.........)))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(...(((((((((.......)))))))).)...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........((((..(..(...(((..((..((.(.((....)).).)).............))..).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((.(...((...((.....)).))....).)))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)..))))...)).)))))))).(...(((((((.....(((..((....((....))....))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....(((.((.((((..((....)).)))))).)))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Crystal structure of the E. coli ribosome bound to dalfopristin and quinupristin.; 16S rRNA 4u26 DA 2897 2.8 RF02540,RF02541 URS000080E25C_1110693 24957822 0003735 0005840 1110693 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<.<<.[..(((.>>......<<<<<<<..<<.)))..]..>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<...>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<.............>...>>.........<<......>>...>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>>....<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>.....<..<<<<<....>>>>>...>>>>>>...>>>...>>>.>........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<..<<....>>...>>>>>..>....>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<..<<<.<<<<<.<<<<<<<<<<<.<<<............<<<<<...<<......<<<<<<<<....>>>>>>>>...>>.............>>>>>...>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>...>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..((..(((((((((.......(((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)).....(((....)))((((..(....)..)))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((..(((......((((((((((.((.(((...(((((......)))))[[(...).(((.....]])))...)))...)).))))))))))...)))....)....((((.(((..[......))).))))......(((((].[[[[)))))..)))......)).)))))...))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((.(((..(((...((.....))...)))...((....))..((((.....)))).....))).)))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((..(...)...))...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((.((..(((.....{.(((((.(.(...(............)..).)..........(......)....)))))...)))..)).)).))...........]]].)...))))))))))...)))))))((((.(..........).))))....))))))(.(((((...(((......(((.((((....)))).)))...)))..)))))..).....))))))(......((.....((((((.......))))))((((.....(((..((..(((((((...((.....)).))))))....[[((....(.(.(((...((......))...)))..))....(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).)))))).(..(((....((((((((((((.((.....))))))))))..))))..[.)))...).(..(((((....)))))...))))))...)))...))))(..).....))))...))....)))))))))))..)).))).....((......)).)))..((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........((.((..((....))...)).))........))))))))..)))))(((((.........)))))........((.(......).(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((((.(.........(((((...((......((((((((....))))))))...)).............)))))).)))).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(..((((.....)))).(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Crystal structure of the E. coli ribosome bound to dalfopristin and quinupristin.; 23S rRNA 4u26 DB 118 2.8 RF00001 URS000080E133_1110693 24957822 0003735 0005840 1110693 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (.(((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))).). Crystal structure of the E. coli ribosome bound to dalfopristin and quinupristin.; 5S rRNA 4u27 AA 1538 2.8 RF00177,RF01959,RF01960 URS000080DDC0_1110693 24957822 0003735 0005840 1110693 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccucc .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<.<<........>>.>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<<..<<<.....>>>>>.....>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>........... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((....(....)....)).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(..(.((((((((.......)))))))).)...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((.....((.(....).)).......(....)...))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.......... Crystal structure of the E. coli ribosome bound to flopristin and linopristin.; 16S rRNA 4u27 BA 2897 2.8 RF02540,RF02541 URS000080E25C_1110693 24957822 0003735 0005840 1110693 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<...>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<....<...........>....>>........<<........>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<..<......>..>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>..>.....>>>>>>>>..>>>>>.<<<<<.......>>>>>.........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<.<<.<<<<.............<<<...<<......<<<.<<<<....>>>>.>>>...>>.............>>>....>>>>.>>.>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((((...))).))...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((...(....(.........)....).......(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((..........))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((.(.((.....))).))))))..)))...[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))..(((.........)))..........((.(......).(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((.(.(.((.(.(...............((....(........(..............).....)..............))......).).)).).).))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Crystal structure of the E. coli ribosome bound to flopristin and linopristin.; 23S rRNA 4u27 BB 119 2.8 RF00001 URS000080E133_1110693 24957822 0003735 0005840 1110693 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>> ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))) Crystal structure of the E. coli ribosome bound to flopristin and linopristin.; 5S rRNA 4u27 CA 1539 2.8 RF00177,RF01959,RF01960 URS000080DDC0_1110693 24957822 0003735 0005840 1110693 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<<....>>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<.......<<<....>>>......>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<........<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<...<<<.....>>>.>.....>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>......>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((.(.....)))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..........)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(...(((((((((.......)))))))).)...)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...(((((((.....(((((((...((........))......)))))))............((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((.(.(..(...((((.((...(.(.((....)).).)..............)).)).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((...((.....)).))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....).).))))..)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Crystal structure of the E. coli ribosome bound to flopristin and linopristin.; 16S rRNA 4u27 DA 2897 2.8 RF02540,RF02541 URS000080E25C_1110693 24957822 0003735 0005840 1110693 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<.)))..]..>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<.>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<...........>>...>>.........<<......>>...>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<.<<....>>.>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><...<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>....><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<..<<....>>...>>>>>..>....>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<..<<<.<<<<<.<<<<<<<<<<<.<<<............<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>...>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>...>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(.(..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))((((..(....)..)))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((.(((.(((...(((((......)))))[[(...).(((.....]])))...)))...))).)))))))))...))))...)....((((.(((..[......))).))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....).......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...((..((((...((((((.)))).))...))))..))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(.(...((.........).)..).).........((......))...)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((.(.(......).).))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).)))))).(..((((...((((((((((((.((.....))))))))))..))))..[))))...).(...((((....))))....))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((......{........)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..((.........(((((..((....))...))))).........)))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((((.(.........(((((...((......((((((((....))))))))...)).............)))))).)))).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Crystal structure of the E. coli ribosome bound to flopristin and linopristin.; 23S rRNA 4u27 DB 118 2.8 RF00001 URS000080E133_1110693 24957822 0003735 0005840 1110693 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))). Crystal structure of the E. coli ribosome bound to flopristin and linopristin.; 5S rRNA 4u3m 2 1750 3.0 RF01960,RF01959,RF00177 URS00005F2C2D_559292 25209664 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucau ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[..................<.....<<.<<.......>>.>>......>.........<<<<<..<......>..>>>>>[...((((((......<<<<<<<<<<......>>..............)))))).....]...<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<..<.<..........>.>..>>.>>>......<<..<...........>..>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..))))))]]]].........[[[{{.......{{...[[[.[[....<<<<<<.<<<<<....<..>....>>>>>.>>>>>>....<<<<<<...............................>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[...((((((((....>>>>>>>>.))))))))..]].....]]....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<.......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>>....>.>>>>>....>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<......<<...>>......>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>....... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[[[[[[[(((....))).....(......).)))))).)...).(.((((..((.......)).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(...(.((....(....)....)).)....)......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((((.....().....))))).)))))).....(((((...............................)))))....(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(......(..(((....]]]]]]]].)))..).....).....))...(((..((..(...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)..))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.((..........))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...(((.)))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>...... Crystal structure of Anisomycin bound to the yeast 80S ribosome; 18S rRNA 4u3m 1 3149 3.0 RF02540,RF02543 URS000061F377_559292 25209664 0003735 0005840 559292 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........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<<.<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<......<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<...<<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>>.<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<.<<........>.>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<<....>>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<....<....>.....>>>>><<.<<<<<..<<<......>>>....>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<...<<.....<<<<....>>>>.....>>.>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<.....>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<...<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>...>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<........>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((......(((..(....)..))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...((((((.....)))))).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((...(....(.........)....).......(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........(..................)....))....))...(((((........)))))]]((((..(((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((((.(...)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.....((.....((((....)))).....))..))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.........)))))))....((((.....((((..(((..........)))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......((((...(((.((....((.(........((((((.....)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).)))...))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(((..(..)....)))..)))))...)))....)))).)))))).))))).. Crystal structure of Anisomycin bound to the yeast 80S ribosome; 25s rRNA 4u3m 3 121 3.0 RF00001 URS000055688D_559292 25209664 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of Anisomycin bound to the yeast 80S ribosome; 5.8s rRNA 4u3m 4 158 3.0 RF00002 URS00001BF64E_559292 25209664 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((...(.]].)..........).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of Anisomycin bound to the yeast 80S ribosome; 5.8s rRNA 4u3m 6 1795 3.0 RF01960,RF01959,RF00177 URS00005F2C2D_559292 25209664 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccucuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccgguccgauuuuuucguacuggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[[..............<.....<<.<<.......>>.>>......>.........<<<<<..<<....>>..>>>>>[...((((((......<<<<<<<<<<<<..>>>>..............)))))).....]...<<<<..<<<.....>>>.>>>>..].]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<<<<...<......>...>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.{{....<<<<<<.<<<..<<<<...............>>>>......>>>.>>>>>>....<<<<<<....<<..<<<<.......>>>>..>>....>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[[..((((((((....>>>>>>>>.)))))))).]]].....}}....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<.......<<........>>..........<<<<<......<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>.......>>>>>....>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<.<<<..<........>....>>>.>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((...............(.....((.(((.....))).))......).........(((((..((....))..)))))(.(.((((((......[[[[[[[.(((....))).....(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(((((.(................).)).)))....(.(.(.(...........))..)......)..((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((..((((...............))))......))).))))))....((((((....((..(((((.....)))))..))....))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(((..(.((((((.....]]]]]]].)))))).).))).....))...(((..((..(...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)..))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((........((.(((........))).))......)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...(((((((........................)))))))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>........ Crystal structure of Anisomycin bound to the yeast 80S ribosome; 18S rRNA 4u3m 5 3150 3.0 RF02540,RF02543 URS000061F377_559292 25209664 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacauggcugggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>...{.....<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<.<<<<<.<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>.>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]....}.............................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<<...........<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<...<<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>>.<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>(><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>).<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<<.....>.>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>...<...<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>...>......>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<.....<..>......>>>>><<.<<<<<<<<<<....>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<..<<<.....<<<<....>>>>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<........>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<......>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<..<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..)))))).))...)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((...........(((((((((((((((((((((((.......(((((((......((((((....)))))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...(.(((.......))).).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.......(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((..((((((....((.....))..)))))....[[(((.((...((....(((....)))........(((..(.(...)..)..)))....))....))...(((((........)))))]]((((.((((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....))))..)))))))).))).))).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((((....))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...(......((((....))))......).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(.((............)).)....((((.....((((..((((........))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.............))))...)))).))))....)))))))).......(((.((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).)).)))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Crystal structure of Anisomycin bound to the yeast 80S ribosome; 25s rRNA 4u3m 7 121 3.0 RF00001 URS000055688D_559292 25209664 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<<............>>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of Anisomycin bound to the yeast 80S ribosome; 5.8s rRNA 4u3m 8 158 3.0 RF00002 URS00001BF64E_559292 25209664 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of Anisomycin bound to the yeast 80S ribosome; 5.8s rRNA 4u3n 2 1750 3.2 RF01960,RF01959,RF00177 URS00005F2C2D_559292 25209664 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucau ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[..................<.....<<.<<<.....>>>.>>......>.........<<<<<..<......>..>>>>>....((((((......<<<<<<<<<<<....>>>..............)))))).........<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<.<<.<<.<..........>.>>.>>..>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.[[....<<<<<<.<<<<<....<..>....>>>>>.>>>>>>....<<<<<<...........<.......>...........>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[...((((((((....>>>>>>>>.))))))))..]].....]]....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<......>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<.......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<<<......>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>>....>.>>>>>....>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<......<<...>>......>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>....... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((..(......)..)))))(.(.((((((......[[[[[[[[(((....))).....(......).)))))).)...).(.((((..((.......)).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....((..(.((..............)).)...))......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((((.....().....))))).))))))....((((((...............................))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(......((.(((....]]]]]]]].))).)).....).....))...(((..((.((...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)).))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.((..........))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...((...))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>...... Crystal structure of CCA trinucleotide bound to the yeast 80S ribosome; 18S ribosomal RNA 4u3n 1 3149 3.2 RF02540,RF02543 URS000061F377_559292 25209664 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>...{.....<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<.<<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]....}.............................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<......<<<<<<<.<<<<<<<<<<<<<<<......<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>...>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>(><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>).<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<<....>>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<.....<..>......>>>>><<.<<<<<<<<<<......>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<...<<.....<<<<....>>>>.....>>.>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<.....>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<..<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>..>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.(((((......(((((((((((((((((((((((.......(((((((......((((.(....).)))).......))))))).....))))).))))))))))........(((....)))....)))))))).....))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...((((((.....)))))).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((..((...((.........))...))......(...(........).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........((....(.....).....))....))....))...(((((........)))))]]((((..(((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((((.(...)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.....((.....((((....)))).....))..))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.........)))))))....((((.....((((..(((..........)))...........>...(((((......)))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......(((((..(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).)))..)))))..(((((.(..(.......)..).....(((((((((.(((....((((.(..(.(..(..)....).)..)))))...)))....)))).)))))..))))).. Crystal structure of CCA trinucleotide bound to the yeast 80S ribosome; 25S ribosomal RNA 4u3n 3 121 3.2 RF00001 URS000055688D_559292 25209664 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of CCA trinucleotide bound to the yeast 80S ribosome; 5S ribosomal RNA 4u3n 4 158 3.2 RF00002 URS00001BF64E_559292 25209664 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((...(.]].)..........).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of CCA trinucleotide bound to the yeast 80S ribosome; 5.8S ribosomal RNA 4u3n 6 1795 3.2 RF01960,RF01959,RF00177 URS00005F2C2D_559292 25209664 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccucuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccgguccgauuuuuucguacuggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[[..............<.....<<.<<.......>>.>>......>.........<<<<<..<<....>>..>>>>>[...((((((......<<<<<<<<<<<<..>>>>..............)))))).....]...<<<<..<<<.....>>>.>>>>..].]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<<<<..............>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.{{....<<<<<<.<<<..<<<<...............>>>>......>>>.>>>>>>....<<<<<<....<<..<<<<.......>>>>..>>....>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[[..((((((((....>>>>>>>>.)))))))).]]].....}}....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>......<<<....>>>..>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<<.....>.>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<......<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>.......>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<......<<<<<<<.<<<..<........>....>>>.>>>>>>>......>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((...............(.....((.(((.....))).))......).........(((((..((....))..)))))(.(.((((((......[[[[[[[.(((....))).....(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(((((.(................).)).)))....(.(((.(...........)).))......)..((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((..((((...............))))......))).))))))....((((((....((..(((((.....)))))..))....))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(((..(.((((((.....]]]]]]].)))))).).))).....))...(((..((..(...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)..))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((......(((((........((.(((........))).))......)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).......)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...(((((((........................)))))))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>........ Crystal structure of CCA trinucleotide bound to the yeast 80S ribosome; 18S ribosomal RNA 4u3n 5 3150 3.2 RF02540,RF02543 URS000061F377_559292 25209664 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacauggcugggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>...{.....<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<.<<<<<<.<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>.>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]....}.............................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<<...........<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>(><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>).<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<<.....>.>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<...............>>>>><<.<<<<<<<<<<....>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<........>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<......>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<.}}}..>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.((((((((..(((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..)))..).))...)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((...........(((((((((((((((((((((((.......(((((((......((((((....)))))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((....((.(((((((.....(((....(((..(.((((...(.((((.....)))).).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.......(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((..((((((....((.....))..)))))....[[(((.((...((....(((....)))..........(....(...).....)......))....))...(((((........)))))]]((((..(((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).))).))).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((((....))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...(......((((....))))......).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(.(..............).)....((((.....((((..((((........))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.............))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Crystal structure of CCA trinucleotide bound to the yeast 80S ribosome; 25S ribosomal RNA 4u3n 7 121 3.2 RF00001 URS000055688D_559292 25209664 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of CCA trinucleotide bound to the yeast 80S ribosome; 5S ribosomal RNA 4u3n 8 158 3.2 RF00002 URS00001BF64E_559292 25209664 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of CCA trinucleotide bound to the yeast 80S ribosome; 5.8S ribosomal RNA 4u3u 2 1750 2.9 RF01960,RF01959,RF00177 URS00005F2C2D_559292 25209664 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucau ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[..................<.....<<.<<.......>>.>>......>.........<<<<<..<......>..>>>>>[...((((((......<<<<<<<<<<......>>..............)))))).....]...<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<.<<..<.<..........>.>..>>..>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.[[....<<<<<<.<<<<<....<..>....>>>>>.>>>>>>....<<<<<<...............................>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[...((((((((....>>>>>>>>.))))))))..]].....]]....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>>....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<.>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>....... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[[[[[[[(((....))).....(......).)))))).)...).(.((((..((.......)).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(...(.((....(....)....)).)....)......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((((.....().....))))).))))))....((((((...............................))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(......((.(((....]]]]]]]].))).)).....).....))...(((..((..(...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)..))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...((...))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>...... Crystal structure of Cycloheximide bound to the yeast 80S ribosome; 18S ribosomal RNA 4u3u 1 3149 2.9 RF02540,RF02543 URS000061F377_559292 25209664 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<.<<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<......<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>>..<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<<....>>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<....<....>.....>>>>><<.<<<<<<<<<<......>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.....<<.....<<<<....>>>>.....>>..>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<.....>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<........>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((......(((..........))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...((((((.....)))))).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((.(((....(.........)....))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........((....(.....).....))....))....))...(((((........)))))]]((((..(((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((((.(...)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.........)))))))....((((.....((((..(((..........)))...........>...(((((......)))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......(((((..(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).)))..)))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(((.((..)..).)))..)))))...)))....)))).)))))).))))).. Crystal structure of Cycloheximide bound to the yeast 80S ribosome; 25S ribosomal RNA 4u3u 3 121 2.9 RF00001 URS000055688D_559292 25209664 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of Cycloheximide bound to the yeast 80S ribosome; 5S ribosomal RNA 4u3u 4 158 2.9 RF00002 URS00001BF64E_559292 25209664 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((...(.]].)..........).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of Cycloheximide bound to the yeast 80S ribosome; 5.8S ribosomal RNA 4u3u 6 1795 2.9 RF01960,RF01959,RF00177 URS00005F2C2D_559292 25209664 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccucuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccgguccgauuuuuucguacuggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[...............<.....<<.<<<.....>>>.>>......>.........<<<<<..<<....>>..>>>>>[...((((((......<<<<<<<<<<<<..>>>>..............)))))).....]...<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<<<<...<......>...>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.{{....<<<<<<.<<<..<<<<...............>>>>......>>>.>>>>>>....<<<<<<....<<..<<<<.......>>>>..>>....>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[[..((((((((....>>>>>>>>.)))))))).]]].....}}....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<.......<<........>>..........<<<<<......<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>.......>>>>>....>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<......<<<<<<<.<<<..<........>....>>>.>>>>>>>......>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((...............(.....((.(((.....))).))......).........(((((..((....))..)))))(.(.((((((......[[[[[[[.(((....))).....(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(((((.(................).)).)))....(.(.(.(...........))..)......)..((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((..((((...............))))......))).))))))....((((((....((..(((((.....)))))..))....))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(((..(.((((((.....]]]]]]].)))))).).))).....))...(((..((..(...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)..))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((........((.(((........))).))......)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...(((((((........................)))))))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>........ Crystal structure of Cycloheximide bound to the yeast 80S ribosome; 18S ribosomal RNA 4u3u 5 3150 2.9 RF02540,RF02543 URS000061F377_559292 25209664 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacauggcugggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<<.<<<<.<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>.>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<<...........<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<<.....>.>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<....<....>.....>>>>><<.<<<<<<<<<<....>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<..<<<.....<<<<....>>>>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<.<.....>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<......>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((.(((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))).....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((...........(((((((((((((((((((((((.......(((((((......((((((....)))))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...(.((((.....)))).).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.......(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((..((((((....((.....))..)))))....[[(((.((...((....(((....)))........(.(..(.(...)..)..).)....))....))...(((((........)))))]]((((..(((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).))).))).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((((....))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...(......((((....))))......).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(.(..............).)....((((.....((((..((((........))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.............))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Crystal structure of Cycloheximide bound to the yeast 80S ribosome; 25S ribosomal RNA 4u3u 7 121 2.9 RF00001 URS000055688D_559292 25209664 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<<............>>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of Cycloheximide bound to the yeast 80S ribosome; 5S ribosomal RNA 4u3u 8 158 2.9 RF00002 URS00001BF64E_559292 25209664 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of Cycloheximide bound to the yeast 80S ribosome; 5.8S ribosomal RNA 4u4n 2 1750 3.1 RF01960,RF01959,RF00177 URS00005F2C2D_559292 25209664 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucau ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[..................<.....<<.<<.......>>.>>......>.........<<<<<..<......>..>>>>>....((((((......<<<<<<<<<<......>>..............)))))).........<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<.<<.<<.<..........>.>>.>>..>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.[[....<<<<<<.<<<<<....<..>....>>>>>.>>>>>>....<<<<<<...........<.......>...........>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[...((((((((....>>>>>>>>.))))))))..]].....]]....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>......<<<....>>>..>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<......>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<.......<<........>>..........<<<<<......<<<<<........<<.<<<........>>>.>>......>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<<<......>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>>......>>>>>....>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<......<<...>>......>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>....... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[[[[[[[(.(....).).....(......).)))))).)...).(.((((..((.......)).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....((..(.(((............))).)...))......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((((.....().....))))).)))))).....(((((...............................)))))....(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(......((.(((....]]]]]]]].))).)).....).....))...(((..((.((...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)).))...))..))))...)).)....((((((........((((.........)))).....))))))......<...(((.((.(((..((((((((.((..........))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...(((.)))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>...... Crystal structure of Edeine bound to the yeast 80S ribosome; 18S ribosomal RNA 4u4n 1 3149 3.1 RF02540,RF02543 URS000061F377_559292 25209664 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[...<.......<<.<<<<<<...>>>>>>.>>.......>.....<<<<<<<.<<<<<<<<<<<<<<<<<<<<.....<<<<......>>>>.(.......<<<......)>>>....>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<......<<<<<<<.<<<<<<<<<<<<<<<......<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>...>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>>..<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<<....>>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<.....<..>......>>>>><<.<<<<<<<<<<......>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<...<<.....<<<<....>>>>.....>>.>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<.....>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<..<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>..>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((......((((.(....).)))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...(.((((.....)))).).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((.(((...((.........))...))).....(...(........).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))..........(...(.....)....)......))....))...(((((........)))))]]((((..(((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((((.(...)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.........)))))))...(((((.....((((..((((........))))...........>...((((((....))))))..))))..))))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).).......(((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).))....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(.(.((..)..).).)..)))))...)))....)))).)))))).))))).. Crystal structure of Edeine bound to the yeast 80S ribosome; 25S ribosomal RNA 4u4n 3 121 3.1 RF00001 URS000055688D_559292 25209664 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of Edeine bound to the yeast 80S ribosome; 5S ribosomal RNA 4u4n 4 158 3.1 RF00002 URS00001BF64E_4932 25209664 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((...(.]].)..........).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of Edeine bound to the yeast 80S ribosome; 5.8S ribosomal RNA 4u4n 6 1795 3.1 RF01960,RF01959,RF00177 URS00005F2C2D_559292 25209664 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccucuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccgguccgauuuuuucguacuggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[[..............<.....<<.<<.......>>.>>......>.........<<<<<..<<....>>..>>>>>....((((((......<<<<<<<<<<<<..>>>>..............)))))).........<<<<..<<<.....>>>.>>>>..].]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<<<<...<......>...>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.{{....<<<<<<.<<...<<<<...............>>>>.......>>.>>>>>>....<<<<<<....<<..<<<<.......>>>>..>>....>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[[..((((((((....>>>>>>>>.)))))))).]]].....}}....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<.......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<<<<<<<.....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>.....>>.>>>...>.>>>>>>>.....>.>>>>>....>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<.<<<..<........>....>>>.>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((...............(.....((.(((.....))).))......).........(((((..((....))..)))))(.(.((((((......[[[[[[[...(....).......(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(((((((.....(....).....)))).)))......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((..((((...............))))......))).))))))....((((((....((..(((((.....)))))..))....))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(((..(.((((((.....]]]]]]].)))))).).))).....))...(((..((..(...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)..))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((........((.(((........))).))......)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...(((((((........................)))))))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>........ Crystal structure of Edeine bound to the yeast 80S ribosome; 18S ribosomal RNA 4u4n 5 3150 3.1 RF02540,RF02543 URS000061F377_559292 25209664 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacauggcugggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>...{.....<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<.<<<<<..<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>......>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]....}.............................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<<...........<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>(><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<<..<<<<<<.....>>>>>>>>>>>....>>>..>>.>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>).<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<<.....>.>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<...............>>>>><<.<<<<<<<<<<<..>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<..<<<.....<<<<....>>>>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<........>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<......>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<.}}}..>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<.<..<<<<<......>>>>>..>>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((..((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))......)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((...........(((((((((((((((((((((((.......(((((((......((((((....)))))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...(.((((.....)))).).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.......(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((..((((((....((.....))..)))))....[[(((.((...((....(((....)))........(((....(...).....)))....))....))...(((((........)))))]]((((..(((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).))).))).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((..)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...(......((((....))))......).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(.((............)).)....((((.....((((..((((........))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).).......(((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).))....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.............))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Crystal structure of Edeine bound to the yeast 80S ribosome; 25S ribosomal RNA 4u4n 7 121 3.1 RF00001 URS000055688D_559292 25209664 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of Edeine bound to the yeast 80S ribosome; 5S ribosomal RNA 4u4n 8 158 3.1 RF00002 URS00001BF64E_4932 25209664 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of Edeine bound to the yeast 80S ribosome; 5.8S ribosomal RNA 4u4o 2 1750 3.6 RF01960,RF01959,RF00177 URS00005F2C2D_559292 25209664 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucau ...<<<<<...[[[[>>>>>[[[..((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[......{{....[[[..................<.....<<.<<.......>>.>>......>.........<<<<<..<......>..>>>>>[...((((((......<<<<<<<<.<......>...............)))))).....]...<<<<..<<<.....>>>.>>>>....]]]...}}....]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<<<<<<....>>>>...>>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<.<<.<<.<<........>>.>>.>>..>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..)))))).]]].........[[[{{.......{{...[[[.[[....<<<<<<.<<<<<....<..>....>>>>>.>>>>>>....<<<<<<...........<.......>...........>>>>>>....<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>..........[[...((((((((....>>>>>>>>.))))))))..]].....]]....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<......>>>....>>>..]]]]..<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<........<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<..<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>........>>>>....>>>.>>>.....>>>>>>>>....>.>>>>>......>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<.>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>....... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(.(.......(((..((..((....(((..................(.....((.(((.....))).))......).........(((((............)))))(.(.((((((......[[[[[[[[.((....))......(......).)))))).)...).(.((((..((.......)).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))).).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....((..(.(((............))).)...))........(..............)............((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((((....(())....))))).)))))).....(((((...............................)))))....(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(....(....(((....]]]]]]]].)))....)...).....))...(((..((.((...((((...(..((((((.....((........))........))))))..)........((....))...))))..)).))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.((...((((((((.(((........)))))))))))...))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((...((.(..(((..(((((......((........))..........(((((......(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((.(..(((((.((((((....))))))...)))))..).)).))..(.((((((.....))))))....)..)))))....))).))).....).))))).......)))))...)).)))..))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..).))......(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((.......((.)).......)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>...... Crystal structure of Geneticin bound to the yeast 80S ribosome; 18S ribosomal RNA 4u4o 1 3149 3.6 RF02540,RF02543 URS000061F377_559292 25209664 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu .........................<<<<<.....<......>......>>>>>.....{.....<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<........<<.<<<<<<...>>>>>>.>>........>....<<<<<<<.<<<<<<<<<<<<<<<<<<<......<<<<......>>>>.(.......<<<......)>>>.....>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]....}.............................<<....>>...............<<<......>>>..................................<<<<<.<<<<<......<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<......>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>>..<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<...............>>>>><<.<<<<<<<<<<<....>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<..<<<.....<<<<....>>>>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{.[[[..<<<<<.<<<<<<<<..<<<<<<<<<.....>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<......>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]...}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<.}}}..>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.....................<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.((.((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))))....)).))))))))...)....(((((((........))))))).....((.((..[[[[[[)).))..)))..................................((....))............(...(((....))).............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((......((((.(....).)))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((....((.(((((((.....(((....(((..(.((((...(.((((.....)))).).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((.(.....((.........)).....).....(...(........).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))..............(.....)...........))....))...(((((........)))))]]((((..(((.(((...((((....)))...(.<.((((((...((((.(((((((((.((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))).).).))))))).))))(...)....))))))...))....)))...))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((((.(...)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..(((((..(...((.....((((....)))).....)).).)))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.(.....).)))))))...(((((.....((((..(((..........)))...........>...((((........))))..))))..))))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].......((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(...(......)...)..)))))...)))....)))).)))))).))))).. Crystal structure of Geneticin bound to the yeast 80S ribosome; 25S ribosomal RNA 4u4o 3 121 3.6 RF00001 URS000055688D_559292 25209664 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.....<.<<<<<..<<....>>.>>>>>...>.>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of Geneticin bound to the yeast 80S ribosome; 5S ribosomal RNA 4u4o 4 158 3.6 RF00002 URS00001BF64E_559292 25209664 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.(((......]]..............)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of Geneticin bound to the yeast 80S ribosome; 5.8S ribosomal RNA 4u4o 6 1791 3.6 RF01960,RF01959,RF00177 URS00005F2C2D_559292 25209664 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccucuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccgguccgauuuuuucguacuggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<............>...>>.>>......{{........[[[..{{..{{....[[[[..............<.....<<.<<.......>>.>>......>.........<<<<<..<<....>>..>>>>>....((((((......<<<<<<<<<<<....>>>..............)))))).........<<<<..<<<.....>>>.>>>>..].]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<<<<...<......>...>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.{{....<<<<<<.<<<..<<<<...............>>>>......>>>.>>>>>>....<<<<<<....<<..<<<<.......>>>>..>>....>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[[..((((((((....>>>>>>>>.)))))))).]]].....}}....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<......>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<........<<........>>..........<<<<<......<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<<<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>...>.>>>>>>>.......>>>>>......>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<....<<<<.<<....<<<<<<<<.<<<..<.<<......<<<<<<<.<<<..<........>....>>>.>>>>>>>......>>.>..>>>.>>>>>>>>...>>.>>>>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((...............((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[[.[[[...(....)................)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(..((((................))))...)....(.(.(.(...........))..)......)..((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((..((((...............))))......))).))))))....((((((...........(.(....))...........))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(((..(.((((.(.....]]].]]].).)))).).))).....))...(((..((.((...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)).))...))..))))...)).)....((((.(....(...((((.........))))...).).))))......<...(((.((.(((..((((((((.(.(........).)))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((......(((((........((.(((........))).))......)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).......)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.....(((.((..(.((((((((.(((..(.((..(...(((((((.(....................).)))))))...)..)).)..))).)))))))))..)).)))..))...)..)..(((((((((....)))))))))>........ Crystal structure of Geneticin bound to the yeast 80S ribosome; 18S ribosomal RNA 4u4o 5 3150 3.6 RF02540,RF02543 URS000061F377_559292 25209664 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacauggcugggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu .........................<<<<<.....<......>......>>>>>.....{.....<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<.<<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]....}.............................<<....>>...............<<<......>>>..................................<<<<<.<<<<<<...........<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<......>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<....<....>....>>>.>>>.>>....>>>>>>.>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>(><.<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<<..<<<<<<.....>>>>>>>>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.........>>>>.>>>>.....>>>>>.>>>>>>>>..>).<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<......<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>....>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>>....<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>.....<<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<...............>>>>><<.<<<<<<<<<<<..>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<..<..<<<....<<<<<....>>>>.>...>>>>.>>>..>>>>><<<<<.........>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{..[[[..<<<<<.<<<<<<<<..<<<<<<........>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<......>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]....}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.<.....>.>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<.}}}..>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.....................<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((..........((.((((((...)))))).)).............((((((.((((((((..(((.(((((.(...({((((......)))))[[(...).(((....}]])))....).)))))...)))..).))...)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.(((((............(((((((((((((((((((((((.......(((((((......((((((....)))))).......))))))).....))))).))))))))))........(((....)))....)))))))).....))))).))))).<((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((.(....).)))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((.((((.((((...(((((((....)))))))...).)))...(((..((.((.......A)))).)))..).))).))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...(.((((.....)))).).)))).)..)))..)).).....)))))...((((..(((.(......))))..)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.......(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((.(..((..((((((....((.....))..)))))....[[(((.((...((....(((....)))........(((....(...).....)))....))....))...(((((........)))))]]((((..(((((.(....(((....))).....[.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....)))))).........).))..))).)))).))).))).....((......)).).)).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((..)))))..)))))).))(...).......(((((((((...((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(...(......((((....))))......).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(.((............)).)...(((((.....((((..((((........))))...........]...((((((....))))))..))))..))))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.............))))...)))).))))....)))))))).......((((((.(...((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............))...).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Crystal structure of Geneticin bound to the yeast 80S ribosome; 25S ribosomal RNA 4u4o 7 121 3.6 RF00001 URS000055688D_559292 25209664 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of Geneticin bound to the yeast 80S ribosome; 5S ribosomal RNA 4u4o 8 158 3.6 RF00002 URS00001BF64E_559292 25209664 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<<<<....>>>>.....<.<<<......>>..............>>>..>...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of Geneticin bound to the yeast 80S ribosome; 5.8S ribosomal RNA 4u4q 2 1750 3.0 RF01960,RF01959,RF00177 URS00005F2C2D_559292 25209664 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucau ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[..................<.....<<.<<.......>>.>>......>.........<<<<<..<......>..>>>>>[...((((((......<<<<<<<<<<<....>>>..............)))))).....]...<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<.<<.<<.<..........>.>>.>>..>>......<<..<...........>..>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..))))))]]]].........[[[{{.......{{...[[[.[[....<<<<<<.<<<<<....<..>....>>>>>.>>>>>>....<<<<<<...........<.......>...........>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[...((((((((....>>>>>>>>.))))))))..]].....]]....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<......>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<.......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<<<......>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>>....>.>>>>>....>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<......<<...>>......>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>....... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[[[[[[[(((....))).....(......).)))))).)...).(.((((..((.......)).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....((..(.(((............))).)...))......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((((.....().....))))).))))))....((((((...............................))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(......((.(((....]]]]]]]].))).)).....).....))...(((..((.((...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)).))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...((...))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>...... Crystal structure of Homoharringtonine bound to the yeast 80S ribosome; 18S ribosomal RNA 4u4q 1 3149 3.0 RF02540,RF02543 URS000061F377_559292 25209664 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<<.<<<<<<<<<<<<<<<<<<<<.....<<<<......>>>>.(.......<<<......)>>>....>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<......<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<....<....>....>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<<....>>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<....<....>.....>>>>><<.<<<<<<<<<<......>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<...<<.....<<<<....>>>>.....>>.>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<.....>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((......((((.(....).)))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...(.((((.....)))).).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((..((...((.........))...))......(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))..........(...(.....)....)......))....))...(((((........)))))]]((((..(((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....))))).(.((((((((((.(...)))))..)))))).).(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.....((.....((((....)))).....))..))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.........)))))))....((((.....((((..((((........))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......(((....(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).)))....)))..(((((.(..(.......)..).....(((((((((.(((....((((.(..(.(.((..)..).).)..)))))...)))....)))).)))))..))))).. Crystal structure of Homoharringtonine bound to the yeast 80S ribosome; 25S ribosomal RNA 4u4q 3 121 3.0 RF00001 URS000055688D_559292 25209664 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of Homoharringtonine bound to the yeast 80S ribosome; 5S ribosomal RNA 4u4q 4 158 3.0 RF00002 URS00001BF64E_559292 25209664 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of Homoharringtonine bound to the yeast 80S ribosome; 5.8S ribosomal RNA 4u4q 6 1795 3.0 RF01960,RF01959,RF00177 URS00005F2C2D_559292 25209664 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccucuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccgguccgauuuuuucguacuggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[...............<.....<<.<<.......>>.>>......>.........<<<<<..<<....>>..>>>>>[...((((((......<<<<<<<<<<<<..>>>>..............)))))).....]...<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<<<<...<......>...>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.{{....<<<<<<.<<...<<<<...............>>>>.......>>.>>>>>>....<<<<<<....<<..<<<<.......>>>>..>>....>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[[..((((((((....>>>>>>>>.)))))))).]]].....}}....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<<<<<<<.....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>.....>>.>>>...>.>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<.<<<..<.........>...>>>.>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((...............(.....((.(((.....))).))......).........(((((..((....))..)))))(.(.((((((......[[[.[[[...(....).......(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(.(((.(................).)).).)......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((..((((...............))))......))).))))))....((((((....((..(((((.....)))))..))....))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(((..(.((((((.....]]].]]].)))))).).))).....))...(((..((..(...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)..))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((........((.(((........))).))......)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...((.((((........................)))).))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>........ Crystal structure of Homoharringtonine bound to the yeast 80S ribosome; 18S ribosomal RNA 4u4q 5 3150 3.0 RF02540,RF02543 URS000061F377_559292 25209664 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacauggcugggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<.<<<<<.<.<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>..>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<<...........<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<...<<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>>.<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>(><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<<..<<<<<<.....>>>>>>>>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>).<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<<.....>.>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<.....<..>......>>>>><<.<<<<<<<<<<<..>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<..<<<.....<<<<....>>>>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<........>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<......>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<<...<<<<<<<<<<}}}.>>>>>..>>>>>..>>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..)))))).))...)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((...........(((((((((((((((((((((((.......(((((((......((((((....)))))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...(.((((.....)))).).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.......(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((..((((((....((.....))..)))))....[[(((.((...((....(((....)))........(.(....(...).....).)....))....))...(((((........)))))]]((((.((((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....))))..)))))))).))).))).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((..)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...(......((((....))))......).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(..................)....((((.....((((..((((........))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.............))))...)))).))))....)))))))).......(((.((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).)).)))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Crystal structure of Homoharringtonine bound to the yeast 80S ribosome; 25S ribosomal RNA 4u4q 7 121 3.0 RF00001 URS000055688D_559292 25209664 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of Homoharringtonine bound to the yeast 80S ribosome; 5S ribosomal RNA 4u4q 8 158 3.0 RF00002 URS00001BF64E_559292 25209664 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of Homoharringtonine bound to the yeast 80S ribosome; 5.8S ribosomal RNA 4u4r 2 1750 2.801 RF01960,RF01959,RF00177 URS00005F2C2D_559292 25209664 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucau ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[..................<.....<<.<<.......>>.>>......>.........<<<<<..<<....>>..>>>>>[...((((((......<<<<<<<<<<<....>>>..............)))))).....]...<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<..<.<..........>.>..>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.[[....<<<<<<.<<<<<....<..>....>>>>>.>>>>>>....<<<<<<...............................>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[...((((((((....>>>>>>>>.))))))))..]].....]]....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>.>.>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>>....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<.>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>....... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[[[[[[[(((....))).....(......).)))))).)...).(.((((..(((.....))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(...(.((....(....)....)).)....)......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((((.....().....))))).))))))....((((((...............................))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(......((.(((....]]]]]]]].))).)).....).....))...(((..((.((...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)).))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...(((.)))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>...... Crystal structure of Lactimidomycin bound to the yeast 80S ribosome; 18S ribosomal RNA 4u4r 1 3149 2.801 RF02540,RF02543 URS000061F377_559292 25209664 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu .........................<<<<<.....<......>......>>>>>...........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<<.<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<......<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>...<...<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<<....>>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>...>......>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>.>>>>>..<<<<.....<<<<<<<.<<...............<<<<<....<....>.....>>>>><<.<<<<<<.<<<......>>>...>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<...<<.....<<<<....>>>>.....>>.>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<.....>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<..<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>..>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((......((((.(....).)))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...((((((.....)))))).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((..((....(.........)....))......(..............).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))..............(.....)...........))....))...(((((........)))))]]((((..(((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((((.(...)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.........)))))))....((((.....((((..((((........))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).).......(((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).))....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......(((((..(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).)))..)))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(((.((..)..).)))..)))))...)))....)))).)))))).))))).. Crystal structure of Lactimidomycin bound to the yeast 80S ribosome; 25S ribosomal RNA 4u4r 3 121 2.801 RF00001 URS000055688D_559292 25209664 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of Lactimidomycin bound to the yeast 80S ribosome; 5S ribosomal RNA 4u4r 4 158 2.801 RF00002 URS00001BF64E_559292 25209664 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((...(.]].)..........).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of Lactimidomycin bound to the yeast 80S ribosome; 5.8S ribosomal RNA 4u4r 6 1795 2.801 RF01960,RF01959,RF00177 URS00005F2C2D_559292 25209664 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccucuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccgguccgauuuuuucguacuggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[...............<.....<<.<<.......>>.>>......>.........<<<<<..<<....>>..>>>>>....((((((......<<<<<<<<<<<<..>>>>..............)))))).........<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<<<<...<......>...>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.{{....<<<<<<.<<<..<<<<...............>>>>......>>>.>>>>>>....<<<<<<....<<..<<<<.......>>>>..>>....>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[[..((((((((....>>>>>>>>.)))))))).]]].....}}....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<<.....>.>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<.<<<..<........>....>>>.>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((...............(.....((.(((.....))).))......).........(((((..((....))..)))))(.(.((((((......[[[[[[[..((....))......(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(((((.(................).)).)))......(.(.(...........))..).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((..((((...............))))......))).))))))....((((((....((..(((((.....)))))..))....))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(((..(.((((((.....]]]]]]].)))))).).))).....))...(((..((.((...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)).))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((........((.(((........))).))......)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...(((((((........................)))))))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>........ Crystal structure of Lactimidomycin bound to the yeast 80S ribosome; 18S ribosomal RNA 4u4r 5 3150 2.801 RF02540,RF02543 URS000061F377_559292 25209664 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacauggcugggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<<.<<<<<.<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>.>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<<...........<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<<.....>.>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>.>>>>>..<<<<.....<<<<<<<.<<...............<<<<<...............>>>>><<.<<<<<<<<<<....>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<..<<<.....<<<<....>>>>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<........>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<......>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((..((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))......)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((...........(((((((((((((((((((((((.......(((((((......((((((....)))))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((....((.(((((((.....(((....(((..(.((((...(.((((.....)))).).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.......(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((..((((((....((.....))..)))))....[[(((.((...((....(((....)))........(.(..(.(...)..)..).)....))....))...(((((........)))))]]((((.((((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....))))..)))))))).))).))).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((((....))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...(......((((....))))......).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(.((............)).)....((((.....((((..((((........))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).).......(((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).))....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.............))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Crystal structure of Lactimidomycin bound to the yeast 80S ribosome; 25S ribosomal RNA 4u4r 7 121 2.801 RF00001 URS000055688D_559292 25209664 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of Lactimidomycin bound to the yeast 80S ribosome; 5S ribosomal RNA 4u4r 8 158 2.801 RF00002 URS00001BF64E_559292 25209664 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of Lactimidomycin bound to the yeast 80S ribosome; 5.8S ribosomal RNA 4u4u 2 1750 3.0 RF01960,RF01959,RF00177 URS00005F2C2D_559292 25209664 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucau ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[..................<.....<<.<<.......>>.>>......>.........<<<<<..<......>..>>>>>....((((((......<<<<<<<<<<<....>>>..............)))))).........<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<.<<.<<.<..........>.>>.>>..>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.[[....<<<<<<.<<<<<....<..>....>>>>>.>>>>>>....<<<<<<...........<.......>...........>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[...((((((((....>>>>>>>>.))))))))..]].....]]....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<......>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<.......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>>....>.>>>>>....>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<...>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>....... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[[[[[[[(((....))).....(......).)))))).)...).(.((((..((.......)).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((....(((.}...)))..)))).)....).).....((..(.((..............)).)...))......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((((.....().....))))).)))))).....(((((...............................)))))....(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(......((.(((....]]]]]]]].))).)).....).....))...(((..((.((...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)).))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...(((.)))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>...... Crystal structure of Lycorine bound to the yeast 80S ribosome; 18S ribosomal RNA 4u4u 1 3149 3.0 RF02540,RF02543 URS000061F377_559292 25209664 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<<.<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<......<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>>..<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<<....>>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<....<....>.....>>>>><<.<<<<<<<<<<......>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<...<<.....<<<<....>>>>.....>>.>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<.....>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>........<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>.....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<<...<<<<<<<<<<}}}.>>>>>..>>>>>..>>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((......((((.(....).)))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...(.((((.....)))).).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((..((...((.........))...))......(...(........).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))..............(.....)...........))....))...(((((........)))))]]((((..(((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((((.(...)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.....((.....((((....)))).....))..))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.........)))))))....((((.....((((..((((........))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......((((...(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).)))...))))..(((((.(..(.......)..).....(((((((((.(((....((((.(..(.(.((..)..).).)..)))))...)))....)))).)))))..))))).. Crystal structure of Lycorine bound to the yeast 80S ribosome; 25S ribosomal RNA 4u4u 3 121 3.0 RF00001 URS000055688D_559292 25209664 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of Lycorine bound to the yeast 80S ribosome; 5S ribosomal RNA 4u4u 4 158 3.0 RF00002 URS00001BF64E_559292 25209664 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((...(.]].)..........).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of Lycorine bound to the yeast 80S ribosome; 5.8S ribosomal RNA 4u4u 6 1795 3.0 RF01960,RF01959,RF00177 URS00005F2C2D_559292 25209664 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccucuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccgguccgauuuuuucguacuggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[...............<.....<<.<<.......>>.>>......>.........<<<<<..<<....>>..>>>>>[...((((((......<<<<<<<<<<<<..>>>>..............)))))).....]...<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<<<<...<......>...>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.{{....<<<<<<.<<<..<<<<...............>>>>......>>>.>>>>>>....<<<<<<....<<..<<<<.......>>>>..>>....>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[[..((((((((....>>>>>>>>.)))))))).]]].....}}....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<.......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>.....>.>>>>>....>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<.<<<..<........>....>>>.>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((...............(.....((.(((.....))).))......).........(((((..((....))..)))))(.(.((((((......[[[[[[[...(....).......(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(((((.(.....(....).....).)).)))......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((..((((...............))))......))).))))))....((((((....((..(((((.....)))))..))....))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(((..(.((((((.....]]]]]]].)))))).).))).....))...(((..((.((...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)).))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((........((.(((........))).))......)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...(((((((........................)))))))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>........ Crystal structure of Lycorine bound to the yeast 80S ribosome; 18S ribosomal RNA 4u4u 5 3150 3.0 RF02540,RF02543 URS000061F377_559292 25209664 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacauggcugggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>...{.....<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<<.<<<<.<<<<<<<<<<<<<<<.....<<<<......>>>>.(.......<<<......)>>>....>>>>>>>>..>>>>>>.>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]....}.............................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<<...........<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>(><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<<..<<<<<<.....>>>>>>>>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>).<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<<.....>.>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>.>>>>>..<<<<.....<<<<<<<.<<...............<<<<<.....<..>......>>>>><<.<<<<<<<<<<<..>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<..<<<.....<<<<....>>>>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<........>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<......>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>........<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>.....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((.(((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..)))).).))...)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((...........(((((((((((((((((((((((.......(((((((......((((((....)))))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...(.((((.....)))).).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.......(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((..((((((....((.....))..)))))....[[(((.((...((....(((....)))........(.(....(...).....).)....))....))...(((((........)))))]]((((..(((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).))).))).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((..)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...(......((((....))))......).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(.((............)).)....((((.....((((..((((........))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.............))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Crystal structure of Lycorine bound to the yeast 80S ribosome; 25S ribosomal RNA 4u4u 7 121 3.0 RF00001 URS000055688D_559292 25209664 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of Lycorine bound to the yeast 80S ribosome; 5S ribosomal RNA 4u4u 8 158 3.0 RF00002 URS00001BF64E_559292 25209664 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of Lycorine bound to the yeast 80S ribosome; 5.8S ribosomal RNA 4u4y 2 1750 3.2 RF01960,RF01959,RF00177 URS00005F2C2D_559292 25209664 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucau ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[..................<.....<<.<<.......>>.>>......>.........<<<<<..<......>..>>>>>[...((((((......<<<<<<<<<<<....>>>..............)))))).....]...<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<.<<.<<.<..........>.>>.>>..>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.[[....<<<<<<.<<<<<....<..>....>>>>>.>>>>>>....<<<<<<...............................>>>>>>....<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>..........[[...((((((((....>>>>>>>>.))))))))..]].....]]....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<......>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<.......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<<<......>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>>....>.>>>>>....>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<......<<...>>......>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>....... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[[[[[[[(((....))).....(......).)))))).)...).(.((((.(((.......))))))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((....(((.}...)))..)))).)....).).....(...(.((....(....)....)).)....)......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((((.....().....))))).)))))).....(((((...............................)))))....(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(......((.(((....]]]]]]]].))).)).....).....))...(((..((.((...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)).))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.((..........))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...((...))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>...... Crystal structure of Pactamycin bound to the yeast 80S ribosome; 18S ribosomal RNA 4u4y 1 3149 3.2 RF02540,RF02543 URS000061F377_559292 25209664 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<<.<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<......<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>(><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>>.>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>).<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>>..<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<<....>>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<...............>>>>><<.<<<<<<<<<<......>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<...<<.....<<<<....>>>>.....>>.>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<.....>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<<...<<<<<<<<<<}}}.>>>>>..>>>>>..>>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<..<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>..>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((......((((.(....).)))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...((((((.....)))))).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((..((....(.........)....))......(..............).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........((....(.....).....))....))....))...(((((........)))))]]((((..(((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((((.(...)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.........)))))))....((((.....((((..(((..........)))...........>...(((((......)))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......(((((..(((.((....((.(........((((((.....)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).)))..)))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(...((..)..)...)..)))))...)))....)))).)))))).))))).. Crystal structure of Pactamycin bound to the yeast 80S ribosome; 25S ribosomal RNA 4u4y 3 121 3.2 RF00001 URS000055688D_559292 25209664 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of Pactamycin bound to the yeast 80S ribosome; 5S ribosomal RNA 4u4y 4 158 3.2 RF00002 URS00001BF64E_559292 25209664 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((...(.]].)..........).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of Pactamycin bound to the yeast 80S ribosome; 5.8S ribosomal RNA 4u4y 6 1795 3.2 RF01960,RF01959,RF00177 URS00005F2C2D_559292 25209664 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccucuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccgguccgauuuuuucguacuggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[...............<.....<<.<<.......>>.>>......>.........<<<<<..<<....>>..>>>>>....((((((......<<<<<<<<<<<<..>>>>..............)))))).........<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<<<<...<......>...>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.{{....<<<<<<.<<<..<<<<...............>>>>......>>>.>>>>>>....<<<<<<....<<..<<<<.......>>>>..>>....>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[[..((((((((....>>>>>>>>.)))))))).]]].....}}....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<.......<<........>>..........<<<<<......<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<<<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>...>.>>>>>>>.......>>>>>....>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<.<<<..<........>....>>>.>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((...............(.....((.(((.....))).))......).........(((((..((....))..)))))(.(.((((((......[[[[[[[..((....))......(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(((((.(................).)).)))......(.(.(...........))..).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((..((((...............))))......))).))))))....((((((....((..(((((.....)))))..))....))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(((..(.((((((.....]]]]]]].)))))).).))).....))...(((..((..(...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)..))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((......(((((........((.(((........))).))......)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).......)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...(((((((........................)))))))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>........ Crystal structure of Pactamycin bound to the yeast 80S ribosome; 18S ribosomal RNA 4u4y 5 3150 3.2 RF02540,RF02543 URS000061F377_559292 25209664 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacauggcugggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>...{.....<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<<.<<<<.<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>.>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]....}.............................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<<...........<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<<..<<<<<<.....>>>>>>>>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.........>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<<.....>.>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<...............>>>>><<.<<<<<<<<<<<..>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<..<<<.....<<<<....>>>>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<.<.....>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<......>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..)))))).))...)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((...........(((((((((((((((((((((((.......(((((((......((((((....)))))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...(.(.(.......).).).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.......(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((..((((((....((.....))..)))))....[[(((.((...((....(((....)))........(((..(((...)).)..)))....))....))...(((((........)))))]]((((..(((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).))).))).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((..)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...(......((((....))))......).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(.(.(..........).).)....((((.....((((..((((........))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.............))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Crystal structure of Pactamycin bound to the yeast 80S ribosome; 25S ribosomal RNA 4u4y 7 121 3.2 RF00001 URS000055688D_559292 25209664 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<<............>>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of Pactamycin bound to the yeast 80S ribosome; 5S ribosomal RNA 4u4y 8 158 3.2 RF00002 URS00001BF64E_559292 25209664 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of Pactamycin bound to the yeast 80S ribosome; 5.8S ribosomal RNA 4u4z 2 1750 3.1 RF01960,RF01959,RF00177 URS00005F2C2D_559292 25209664 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucau ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[..................<.....<<.<<<.....>>>.>>......>.........<<<<<..<......>..>>>>>[...((((((......<<<<<<<<<<<....>>>..............)))))).....]...<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<.<<.<<.<..........>.>>.>>..>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.[[....<<<<<<.<<<<<....<..>....>>>>>.>>>>>>....<<<<<<...............................>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[...((((((((....>>>>>>>>.))))))))..]].....]]....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<......>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<.......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<<<......>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>>....>.>>>>>....>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<...>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>.........<<<<<<<<<<..>>>>>>>>>>....... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[[[[[[.(((....))).....(......).)))))).)...).(.((((..((.......)).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....((..(.((..............)).)...))......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((((.....().....))))).)))))).....(((((....(.....................)....)))))....(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(....(.((.(((.....]]]]]]].))).)).)...).....))...(((..((.((...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)).))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.((..........))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...((...))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>...... Crystal structure of Phyllanthoside bound to the yeast 80S ribosome; 18S ribosomal RNA 4u4z 1 3149 3.1 RF02540,RF02543 URS000061F377_559292 25209664 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<.<<<<<<<<<<<<<<<<<<<<<.....<<<<......>>>>.(.......<<<......)>>>....>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<......<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<....<....>....>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<<..<<<<<<.....>>>>>>>>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.........>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>>..<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<...............>>>>><<.<<<<<.<<<<......>>>>...>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<...<<.....<<<<....>>>>.....>>.>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<.....>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<.}}}..>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<..<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<....<<<......>>>....>>>>>.>>>>>>.............>>.>>>..>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((.(((...({((((......)))))[[(...).(((....}]])))....))).))))..))))))))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((......(((..(....)..))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...((((((.....)))))).)))).)..)))..)).).....)))))...((((..(((.(......))))..)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((..((....(.........)....))......(...(........).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........((....(.....).....))....))....))...(((((........)))))]]((((..(((.(((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....)))...))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((((.(...)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.....((.....((((....)))).....))..))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.........)))))))...(((((.....((((..(((..........)))...........>...((((((....))))))..))))..))))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......(((....(((.((....((.(........((((((.....)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).)))....)))..(((((.(..(.......)..).....(((((((((.(((....((((.(..(.((((..)..))).)..)))))...)))....)))).)))))..))))).. Crystal structure of Phyllanthoside bound to the yeast 80S ribosome; 25S ribosomal RNA 4u4z 3 121 3.1 RF00001 URS000055688D_559292 25209664 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of Phyllanthoside bound to the yeast 80S ribosome; 5S ribosomal RNA 4u4z 4 158 3.1 RF00002 URS00001BF64E_559292 25209664 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((...(.]].)..........).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of Phyllanthoside bound to the yeast 80S ribosome; 5.8S ribosomal RNA 4u4z 6 1795 3.1 RF01960,RF01959,RF00177 URS00005F2C2D_559292 25209664 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccucuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccgguccgauuuuuucguacuggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[[..............<.....<<.<<.......>>.>>......>.........<<<<<..<<....>>..>>>>>[...((((((......<<<<<<<<<<<....>>>..............)))))).....]...<<<<..<<<.....>>>.>>>>..].]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<<<<...<......>...>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.{{....<<<<<<.<<<<.<<<<...............>>>>.....>>>>.>>>>>>....<<<<<<....<<..<<<<.......>>>>..>>....>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[[..((((((((....>>>>>>>>.)))))))).]]].....}}....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<.......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>.....>.>>>>>....>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<.<<<..<........>....>>>.>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((...............((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[[[[[[..((....))......(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(((((.(................).)).)))....(.(((.(...........)).))......)..((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((.(((((...............))))....).))).))))))....((((((....((..(((.(.....).)))..))....))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(((..(.((((((.....]]]]]]].)))))).).))).....))...(((..((.((...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)).))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((........((.(((........))).))......)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((...((((.((((((....))))))...))))...)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...(((((((.((..................)).)))))))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>........ Crystal structure of Phyllanthoside bound to the yeast 80S ribosome; 18S ribosomal RNA 4u4z 5 3150 3.1 RF02540,RF02543 URS000061F377_559292 25209664 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacauggcugggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>...{.....<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<.<<<<<<.<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>.>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]....}.............................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<<...........<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>>..<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<<.....>.>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<...............>>>>><<.<<<<<<<<<<<..>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<..<..<<<.....<<<<....>>>>.....>>>>.>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<........>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<......>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<..<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<.}}}..>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((..((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))......)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((...........(((((((((((((((((((((((.......(((((((......((((((....)))))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((....((.(((((((.....(((....(((..(.((((...(..(((.....)))..).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.......(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((..((((((....((.....))..)))))....[[(((.((...((....(((....)))........(((..(........)..)))....))....))...(((((........)))))]]((((..(((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).))).))).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((..)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...(......((((....))))......).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(.(..............).)....((((.....((((..((((........))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.............))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Crystal structure of Phyllanthoside bound to the yeast 80S ribosome; 25S ribosomal RNA 4u4z 7 121 3.1 RF00001 URS000055688D_559292 25209664 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<<............>>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of Phyllanthoside bound to the yeast 80S ribosome; 5S ribosomal RNA 4u4z 8 158 3.1 RF00002 URS00001BF64E_559292 25209664 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of Phyllanthoside bound to the yeast 80S ribosome; 5.8S ribosomal RNA 4u50 2 1750 3.2 RF01960,RF01959,RF00177 URS00005F2C2D_559292 25209664 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucau ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[..................<.....<<.<<.......>>.>>......>.........<<<<<..<......>..>>>>>....((((((......<<<<<<<<<<......>>..............)))))).........<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<.<<.<<.<..........>.>>.>>..>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.[[....<<<<<<.<<<<<....<..>....>>>>>.>>>>>>....<<<<<<...........<.......>...........>>>>>>....<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>..........[[...((((((((....>>>>>>>>.))))))))..]].....]]....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<......>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<.......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>>....>.>>>>>....>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<......<<...>>......>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>....... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[[[[[[[(((....))).....(......).)))))).)...).(.((((..((.(....))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((....(((.}...)))..)))).)....).).....((..(.(((............))).)...))......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((((............))))).))))))....((((((...............................))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(....(.((.(((....]]]]]]]].))).)).)...).....))...(((..((.((...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)).))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...((...))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>...... Crystal structure of Verrucarin bound to the yeast 80S ribosome; 18S ribosomal RNA 4u50 1 3149 3.2 RF02540,RF02543 URS000061F377_559292 25209664 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<<.<<<<<<<<<<<<<<<<<<<<.....<<<<......>>>>.(.......<<<......)>>>....>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<......<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<<..<<<<<<.....>>>>>>>>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.........>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<......<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>....>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>>..<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<<....>>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<....<....>.....>>>>><<.<<<<<<<<<<......>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<...<<.....<<<<....>>>>.....>>.>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<.....>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<...<<<<<<<<<<<}}}.>>>>>..>>>>>>..>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((......((((.(....).)))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...(.((((.....)))).).)))).)..)))..)).).....)))))...(.((.((((.(......))))).)).).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((.(((...((.........))...))).....(...(........).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))..........(...(.....)....)......))....))...(((((........)))))]]((((..(((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((((.(...)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.(.....).)))))))....((((.....((((..((((........))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......((((...(((.((....((.(........((((((.....)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).)))...))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(((.((..)..).)))..)))))...)))....)))).)))))).))))).. Crystal structure of Verrucarin bound to the yeast 80S ribosome; 25S ribosomal RNA 4u50 3 121 3.2 RF00001 URS000055688D_559292 25209664 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of Verrucarin bound to the yeast 80S ribosome; 5S ribosomal RNA 4u50 4 158 3.2 RF00002 URS00001BF64E_559292 25209664 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of Verrucarin bound to the yeast 80S ribosome; 5.8S ribosomal RNA 4u50 6 1795 3.2 RF01960,RF01959,RF00177 URS00005F2C2D_559292 25209664 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccucuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccgguccgauuuuuucguacuggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[...............<.....<<.<<.......>>.>>......>.........<<<<<..<<....>>..>>>>>....((((((......<<<<<<<<<<<<..>>>>..............)))))).........<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<<<<...<......>...>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.{{....<<<<<<.<<...<<<<...............>>>>.......>>.>>>>>>....<<<<<<.<..<<..<<<<.......>>>>..>>...>>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[[..((((((((....>>>>>>>>.)))))))).]]].....}}....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<.......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<.....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>.....>>.>>>.....>>>>>>>.....>.>>>>>....>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<......<<<<<<<.<<<..<.........>...>>>.>>>>>>>......>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((...............(.....((.(((.....))).))......).........(((((..((....))..)))))(.(.((((((......[[[[[[[...(....).......(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(((((.(.....(....).....).)).)))......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.((...((((...............)))).......)).))))))....((((((....((..(((((.....)))))..))....))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(((..(.((((((.....]]]]]]].)))))).).))).....))...(((..((.((...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)).))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))........(.(((((.(....(((((........((.(((........))).))......)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).))))))..)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...(((((((.((..................)).)))))))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>........ Crystal structure of Verrucarin bound to the yeast 80S ribosome; 18S ribosomal RNA 4u50 5 3150 3.2 RF02540,RF02543 URS000061F377_559292 25209664 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacauggcugggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<<.<<<<...<<<<<<<<<<<<<.....<<<<......>>>>.(.......<<<......)>>>....>>>>>>>>..>>>>>.......>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<<...........<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<....<.<<<<<<....>>>>>>>......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>(><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<<..<<<<<<.....>>>>>>>>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>).<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>>..<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<<.....>.>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<...............>>>>><<.<<<<<<<<<<<..>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<..<<<.....<<<<....>>>>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{.[[[[..<<<<<.<<<<<<<<..<<<<<<........>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<......>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]...}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<..<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<.}}}..>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((.(.(.(((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..)))..).)....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((...........(((((((((((((((((((((((.......(((((((......((((((....)))))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...(.(.((.....)).).).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.......(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((.(..((..((((((....((.....))..)))))....[[(((.((...((....(((....)))........(.(....(...).....).)....))....))...(((((........)))))]]((((.((((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....))))..)))))))).))).))).....((......)).).)).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((..)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...(......((((....))))......).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(..................)....((((.....((((..(((((......)))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.............))))...)))).))))....)))))))).......(((.((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).)).)))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Crystal structure of Verrucarin bound to the yeast 80S ribosome; 25S ribosomal RNA 4u50 7 121 3.2 RF00001 URS000055688D_559292 25209664 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of Verrucarin bound to the yeast 80S ribosome; 5S ribosomal RNA 4u50 8 158 3.2 RF00002 URS00001BF64E_559292 25209664 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of Verrucarin bound to the yeast 80S ribosome; 5.8S ribosomal RNA 4u51 2 1750 3.2 RF01960,RF01959,RF00177 URS00005F2C2D_559292 25209664 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucau ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[..................<.....<<.<<.......>>.>>......>.........<<<<<..<......>..>>>>>....((((((......<<<<<<<<<<<....>>>..............)))))).........<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<.<<.<..........>.>>.>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.[[....<<<<<<.<<<<<....<..>....>>>>>.>>>>>>....<<<<<<...............................>>>>>>....<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>..........[[...((((((((....>>>>>>>>.))))))))..]].....]]....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<......>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<.......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<..<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>........>>>>....>>>.>>>.....>>>>>>>.....>.>>>>>....>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<......<<...>>......>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>....... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[[[[[[[(.(....).).....(......).)))))).)...).(.((((..((.(....))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((....(((.}...)))..)))).)....).).....((..(.((..............)).)...))......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((((.....().....))))).)))))).....(((((...............................)))))....(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(....(.((.(((....]]]]]]]].))).)).)...).....))...(((..((.((...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)).))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...(.(..))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>...... Crystal structure of Narciclasine bound to the yeast 80S ribosome; 18S ribosomal RNA 4u51 1 3149 3.2 RF02540,RF02543 URS000061F377_559292 25209664 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<<.<<<<<<<<<<<<<<<<<<<<.....<<<<......>>>>.(.......<<<......)>>>....>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<......<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>>..<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<<....>>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<...............>>>>><<.<<<<<.<<<<......>>>>...>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<...<<.....<<<<....>>>>.....>>.>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<.....>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<...<<<<<<<<<<<}}}.>>>>>..>>>>>>..>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<..<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>..>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((......(((..(....)..))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...((((((.....)))))).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((.(((...((.........))...))).....(...(........).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...((((((...((.....)).))))))....[[(((.((...((....(((....)))........(.(...(.....)....).)....))....))...(((((........)))))]]((((..(((((.(...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....).))..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((((.(...)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.....((.....((((....)))).....))..))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.........)))))))....((((.....((((..((((........))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......(..(.(.((((((...((.......))...))))))...))...)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......(((....(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).)))....)))..(((((.(..(.......)..).....(((((((((.(((....((((.(..(.(.((..)..).).)..)))))...)))....)))).)))))..))))).. Crystal structure of Narciclasine bound to the yeast 80S ribosome; 25S ribosomal RNA 4u51 3 121 3.2 RF00001 URS000055688D_559292 25209664 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of Narciclasine bound to the yeast 80S ribosome; 5S ribosomal RNA 4u51 4 158 3.2 RF00002 URS00001BF64E_559292 25209664 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((...(.]].)..........).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of Narciclasine bound to the yeast 80S ribosome; 5.8S ribosomal RNA 4u51 6 1795 3.2 RF01960,RF01959,RF00177 URS00005F2C2D_559292 25209664 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccucuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccgguccgauuuuuucguacuggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[...............<.....<<.<<.......>>.>>......>.........<<<<<..<<....>>..>>>>>....((((((......<<<<<<<<<<<<..>>>>....<........>)))))).........<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<<<<..............>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.{{....<<<<<<.<<...<<<<...............>>>>.......>>.>>>>>>....<<<<<<....<<..<<<<.......>>>>..>>....>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[[..((((((((....>>>>>>>>.)))))))).]]].....}}....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<......<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<.....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>.....>>.>>>.....>>>>>>>.......>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<.<<<..<........>....>>>.>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((...............(.....((.(((.....))).))......).........(((((..((....))..)))))(.(.((((((......[[[[[[[...(....).......(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(((((.(................).)).)))......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.((...((((...............)))).......)).))))))....((((((....((..(((((.....)))))..))....))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(((..(.((((((.....]]]]]]].)))))).).))).....))...(((..((..(...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)..))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((.......(........)...........(((((.(....(..((........((.(((........))).))......))..)...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...((.(((...(..................)...))).))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>........ Crystal structure of Narciclasine bound to the yeast 80S ribosome; 18S ribosomal RNA 4u51 5 3150 3.2 RF02540,RF02543 URS000061F377_559292 25209664 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacauggcugggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>...{.....<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<<.<<<<..<<<<<<<<<<<<<<.....<<<<......>>>>.(.......<<<......)>>>....>>>>>>>>..>>>>>>......>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]....}.............................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<<...........<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>(><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<<..<<<<<<.....>>>>>>>>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.........>>>>.>>>>.....>>>>>.>>>>>>>>.>>).<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<<.....>.>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<...............>>>>><<.<<<<<<<<<<<..>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<..<<<.....<<<<....>>>>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<........>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<......>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..)))))).))...)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((...........(((((((((((((((((((((((.......(((((((......((((((....)))))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.(((((..(.((((.....)))).)))))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.......(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((..(((((((...((.....)).))))))....[[(((.((...((....(((....)))........(.(....(...).....).)....))....))...(((((........)))))]]((((.((((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....))))..)))))))).))).))).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((..)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...(......((((....))))......).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(.(..............).)....((((.....((((..(((..........)))...........>...((((.(....).))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.............))))...)))).))))....)))))))).......(((.((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).)).)))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Crystal structure of Narciclasine bound to the yeast 80S ribosome; 25S ribosomal RNA 4u51 7 121 3.2 RF00001 URS000055688D_559292 25209664 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of Narciclasine bound to the yeast 80S ribosome; 5S ribosomal RNA 4u51 8 158 3.2 RF00002 URS00001BF64E_559292 25209664 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.......<<<......>>..............>>>......>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of Narciclasine bound to the yeast 80S ribosome; 5.8S ribosomal RNA 4u52 2 1750 3.0 RF01960,RF01959,RF00177 URS00005F2C2D_559292 25209664 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucau ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[..................<.....<<.<<.......>>.>>......>.........<<<<<..<......>..>>>>>[...((((((......<<<<<<<<<<......>>..............)))))).....]...<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<.<<..<.<..........>.>..>>..>>......<<..<...........>..>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..))))))]]]].........[[[{{.......{{...[[[.[[....<<<<<<.<<<<<....<..>....>>>>>.>>>>>>....<<<<<<...............................>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[...((((((((....>>>>>>>>.))))))))..]].....]]....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<.......<<........>>..........<<<<<......<<<<<........<<.<<<........>>>.>>......>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>>......>>>>>....>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<......<<...>>......>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>....... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[[[[[[[(((....))).....(......).)))))).)...).(.((((..((.......)).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....((..(.(((............))).)...))......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((((............))))).))))))....((((((...............................))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(......(..(((....]]]]]]]].)))..).....).....))...(((..((.((...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)).))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...(((.)))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>...... Crystal structure of Nagilactone C bound to the yeast 80S ribosome; 18S ribosomal RNA 4u52 1 3149 3.0 RF02540,RF02543 URS000061F377_559292 25209664 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<<.<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<......<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<....<....>....>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<<....>>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<....<<..>>.....>>>>><<.<<<<<..<<<......>>>....>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<...<<.....<<<<....>>>>.....>>.>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<.....>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<......>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((......((((.(....).)))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...((((((.....)))))).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((..((...((.........))...))......(...(........).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........(.(...(.....)....).)....))....))...(((((........)))))]]((((..(((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((((.(...)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.........)))))))....((((.....((((..((............))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......(..(.(.((((((...((.......))...))))))...))...)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......((((...(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).)))...))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(.(.((..)..).).)..)))))...)))....)))).)))))).))))).. Crystal structure of Nagilactone C bound to the yeast 80S ribosome; 25S ribosomal RNA 4u52 3 121 3.0 RF00001 URS000055688D_559292 25209664 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of Nagilactone C bound to the yeast 80S ribosome; 5S ribosomal RNA 4u52 4 158 3.0 RF00002 URS00001BF64E_559292 25209664 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((...(.]].)..........).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of Nagilactone C bound to the yeast 80S ribosome; 5.8S ribosomal RNA 4u52 6 1795 3.0 RF01960,RF01959,RF00177 URS00005F2C2D_559292 25209664 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccucuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccgguccgauuuuuucguacuggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[[..............<.....<<.<<.......>>.>>......>.........<<<<<..<<....>>..>>>>>[...((((((......<<<<<<<<<<<<..>>>>....<........>)))))).....]...<<<<..<<<.....>>>.>>>>..].]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<<<<...<......>...>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.{{....<<<<<<.<<...<<<<...............>>>>.......>>.>>>>>>....<<<<<<....<<..<<<<.......>>>>..>>....>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[[..((((((((....>>>>>>>>.)))))))).]]].....}}....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<<.....>.>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<......<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>.......>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<.<<<..<........>....>>>.>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((...............(.....((.(((.....))).))......).........(((((..((....))..)))))(.(.((((((......[[[[[[[.(((....))).....(......).)))))).)...).(.((((..(((.....))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(((((.(................).)).)))......(.(.(...........))..).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((..((((...............))))......))).))))))....((((((....((..(((((.....)))))..))....))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(((..(.((((((.....]]]]]]].)))))).).))).....))...(((..((..(...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)..))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((........((.(((........))).))......)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...(((((((.((..................)).)))))))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>........ Crystal structure of Nagilactone C bound to the yeast 80S ribosome; 18S ribosomal RNA 4u52 5 3150 3.0 RF02540,RF02543 URS000061F377_559292 25209664 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacauggcugggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<.<<<<<.<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>.>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<<...........<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<....<.<<<<<<....>>>>>>>......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<<..<<<<<<.....>>>>>>>>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.........>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<<.....>.>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<...............>>>>><<.<<<<<<<<<<<..>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<..<<<.....<<<<....>>>>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<.<.....>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<......>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<.<..<<<<<......>>>>>..>>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.((((((((.((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..)))).).))...)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((...........(((((((((((((((((((((((.......(((((((......((((((....)))))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((....((.(((((((.....(((....(((..(.((((...(.((((.....)))).).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.......(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((..((((((....((.....))..)))))....[[(((.((...((....(((....)))........(.(..(.(...)..)..).)....))....))...(((((........)))))]]((((.((((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....))))..)))))))).))).))).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((..)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...(......((((....))))......).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(.((............)).)....((((.....((((..((((........))))...........>...((((.(....).))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......(..(.(.((((((...((.......))...))))))...))...)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.............))))...)))).))))....)))))))).......(((.((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).)).)))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(((.((..)..).)))..)))))...)))....)))).)))))).))))).. Crystal structure of Nagilactone C bound to the yeast 80S ribosome; 25S ribosomal RNA 4u52 7 121 3.0 RF00001 URS000055688D_559292 25209664 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of Nagilactone C bound to the yeast 80S ribosome; 5S ribosomal RNA 4u52 8 158 3.0 RF00002 URS00001BF64E_559292 25209664 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of Nagilactone C bound to the yeast 80S ribosome; 5.8S ribosomal RNA 4u53 2 1750 3.3 RF01960,RF01959,RF00177 URS00005F2C2D_559292 25209664 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucau ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[..................<.....<<.<<.......>>.>>......>.........<<<<<..<......>..>>>>>....((((((......<<<<<<<<<<......>>..............)))))).........<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<.<<.<<.<..........>.>>.>>..>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.[[....<<<<<<.<<<<<....<..>....>>>>>.>>>>>>....<<<<<<...........<.......>...........>>>>>>....<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>..........[[...((((((((....>>>>>>>>.))))))))..]].....]]....<<<<<<.<<...<<<<..<<<.<<<<<<.<...<<<......>>>......>.>>>>>>.>>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<......>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<.......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<<<......>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<.<<<<....>>>>.>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>>....>.>>>>>....>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<......<<...>>......>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>....... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[[[[[[[..(....).......(......).)))))).)...).(.((((..((.......)).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....((..(.(((............))).)...))......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((((.....().....))))).))))))....((((((...............................))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..)))................((.(((....]]]]]]]].))).))...........))...(((..((..(...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)..))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...((...))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>...... Crystal structure of Deoxynivalenol bound to the yeast 80S ribosome; 18S ribosomal RNA 4u53 1 3149 3.3 RF02540,RF02543 URS000061F377_559292 25209664 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[...<.......<<.<<<<<<...>>>>>>.>>.......>.....<<<<<<<.<<<<<<<<<<<<<<<<<<<<.....<<<<......>>>>.(.......<<<......)>>>....>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<......<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>>..<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<<....>>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>.>>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<...............>>>>><<.<<<<<<<<<<......>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<...<<.....<<<<....>>>>.....>>.>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<.....>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<...<<<<<<<<<<.}}}..>>>>..>>>>>>..>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.....................<<<<<<<<<.<<<....<<<<....<<<<........>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((......((((.(....).)))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...((((((.....)))))).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...((((((...((.....)).))))))....[[(((.((...((....(((....)))........(.(...(.....)....).)....))....))...(((((........)))))]]((((..(((...(...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....).....))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((((.(...)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.....((.....((((....)))).....))..))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.(.....).)))))))...(((((.....((((..((((........))))...........>...((((((....))))))..))))..))))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......(..(.(.((((((...((.......))...))))))...))...)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(....(..)......)..)))))...)))....)))).)))))).))))).. Crystal structure of Deoxynivalenol bound to the yeast 80S ribosome; 25S ribosomal RNA 4u53 3 121 3.3 RF00001 URS000055688D_559292 25209664 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of Deoxynivalenol bound to the yeast 80S ribosome; 5S ribosomal RNA 4u53 4 158 3.3 RF00002 URS00001BF64E_559292 25209664 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of Deoxynivalenol bound to the yeast 80S ribosome; 5.8S ribosomal RNA 4u53 6 1795 3.3 RF01960,RF01959,RF00177 URS00005F2C2D_559292 25209664 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccucuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccgguccgauuuuuucguacuggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[...............<.....<<.<<.......>>.>>......>.........<<<<<..<<....>>..>>>>>....((((((......<<<<<<<<<<<<..>>>>..............)))))).........<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<<<<..............>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.{{....<<<<<<.<<<..<<<<...............>>>>......>>>.>>>>>>....<<<<<<....<<..<<<<.......>>>>..>>....>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[[..((((((((....>>>>>>>>.)))))))).]]].....}}....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>......<<<....>>>..>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<.....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<..<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>........>>>>.....>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<.<<<..<........>....>>>.>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((...............((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[[.[[[..((....))......(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(((((.(................).)).)))......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((..((((...............))))......))).))))))....((((((....((..(((((.....)))))..))....))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(((..(.((((((.....]]].]]].)))))).).))).....))...(((..((..(...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)..))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((...((.((((((......((........))..........(((((.(....(((.(........((.(((........))).))......).)))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))..(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...(((((((.((..................)).)))))))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>........ Crystal structure of Deoxynivalenol bound to the yeast 80S ribosome; 18S ribosomal RNA 4u53 5 3150 3.3 RF02540,RF02543 URS000061F377_559292 25209664 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacauggcugggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>...{.....<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<<.<<<<.<.<<<<<<<<<<<<<.....<<<<......>>>>.(.......<<<......)>>>....>>>>>>>>..>>>>>..>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]....}.............................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<<...........<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<....<.<<<<<<....>>>>>>>......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<...<<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>>.<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<<..<<<<<<.....>>>>>>>>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>>..<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<<.....>.>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<.....<..>......>>>>><<.<<<<<<<<<<<..>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<..<<<.....<<<<....>>>>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<........>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<......>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<..<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.....................<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((.((.((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..)))).).)....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((...........(((((((((((((((((((((((.......(((((((......((((((....)))))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...(.((((.....)))).).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.......(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((..((((((....((.....))..)))))....[[(((.((...((....(((....)))........(((....(...).....)))....))....))...(((((........)))))]]((((..(((((((...((((....)))...(.<.((((((...((((.(((((((.((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......)))))))))))...))))))).))))(...)....))))))...))....))))..))).)))).))).))).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((..)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...(......((((....))))......).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(.(..............).)....((((.....((((..((((........))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.............))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Crystal structure of Deoxynivalenol bound to the yeast 80S ribosome; 25S ribosomal RNA 4u53 7 121 3.3 RF00001 URS000055688D_559292 25209664 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of Deoxynivalenol bound to the yeast 80S ribosome; 5S ribosomal RNA 4u53 8 158 3.3 RF00002 URS00001BF64E_559292 25209664 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of Deoxynivalenol bound to the yeast 80S ribosome; 5.8S ribosomal RNA 4u55 2 1750 3.2 RF01960,RF01959,RF00177 URS00005F2C2D_559292 25209664 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucau ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[..................<.....<<.<<<.....>>>.>>......>.........<<<<<..<......>..>>>>>....((((((......<<<<<<<<<<<....>>>..............)))))).........<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<.<<.<..........>.>>.>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.[[....<<<<<<.<<<<<....<..>....>>>>>.>>>>>>....<<<<<<...............................>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[...((((((((....>>>>>>>>.))))))))..]].....]]....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<......>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<.......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<<<......>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>>....>.>>>>>....>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<......<<...>>......>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>....... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[[[[[[[(((....))).....(......).)))))).)...).(.((((..((.......)).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((....(((.}...)))..)))).)....).).....((..(.((..............)).)...))......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((((............))))).))))))....((((((...............................))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(......((.(((....]]]]]]]].))).)).....).....))...(((..((..(...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)..))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((.(.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..).)))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...((...))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>...... Crystal structure of Cryptopleurine bound to the yeast 80S ribosome; 18S ribosomal RNA 4u55 1 3149 3.2 RF02540,RF02543 URS000061F377_559292 25209664 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<<.<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<......<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<....<....>....>>>.>>>.>>....>>>>>>.>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<......<<<....>>><.<<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>>.<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<......<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>....>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>>..<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<<....>>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<...............>>>>><<.<<<<<<<<<<......>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.....<<.....<<<<....>>>>.....>>..>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<.....>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<.}}}..>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<..<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>..>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((......((((.(....).)))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...((.(((.....))).)).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((.(((...((.........))...))).....(...(........).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((.(..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........(.....(.....)......)....))....))...(((((........)))))]]((((..(((.(.(...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....).)...))).)))).)))..)).....((......)).).)).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((((.(...)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.(.....).)))))))....((((.....((((..(((..........)))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......(((((..(((.((....((.(........((((((.....)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).)))..)))))..(((((.(..(.......)..).....(((((((((.(((....((((.(..(.(..(..)....).)..)))))...)))....)))).)))))..))))).. Crystal structure of Cryptopleurine bound to the yeast 80S ribosome; 25S ribosomal RNA 4u55 3 121 3.2 RF00001 URS000055688D_559292 25209664 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of Cryptopleurine bound to the yeast 80S ribosome; 5S ribosomal RNA 4u55 4 158 3.2 RF00002 URS00001BF64E_559292 25209664 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((...(.]].)..........).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of Cryptopleurine bound to the yeast 80S ribosome; 5.8S ribosomal RNA 4u55 6 1795 3.2 RF01960,RF01959,RF00177 URS00005F2C2D_559292 25209664 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccucuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccgguccgauuuuuucguacuggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[[..............<.....<<.<<<.....>>>.>>......>.........<<<<<..<<....>>..>>>>>....((((((......<<<<<<<<<<<<..>>>>....<<......>>)))))).........<<<<..<<<.....>>>.>>>>..].]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<<<<..............>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.{{....<<<<<<.<<...<<<<...............>>>>.......>>.>>>>>>....<<<<<<....<<..<<<<.......>>>>..>>....>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[[..((((((((....>>>>>>>>.)))))))).]]].....}}....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<......<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<<<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>...>.>>>>>>>.......>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<.<<<..<........>....>>>.>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((...............((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[[[[[[.(((....))).....(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(((((.(................).)).)))......(.(.(...........))..).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.((...((((...............)))).......)).))))))....((((((....((..(((((.....)))))..))....))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(((..(.((((.(.....]]]]]]].).)))).).))).....))...(((..((..(...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)..))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((........((.(((........))).))......)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...((.((((........................)))).))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>........ Crystal structure of Cryptopleurine bound to the yeast 80S ribosome; 18S ribosomal RNA 4u55 5 3150 3.2 RF02540,RF02543 URS000061F377_559292 25209664 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacauggcugggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>...<.....<<....>>..<<<<<......<<.....>>.....>>>>>..<<<..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<<.<<<<.<.<<<<<<<<<<<<<.....<<<<......>>>>.(.......<<<......)>>>....>>>>>>>>..>>>>>..>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>....>.............................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<<...........<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>(><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<<..<<<<<<.....>>>>>>>>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.........>>>>.>>>>.....>>>>>.>>>>>>>>.>>).<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>>..<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<<.....>.>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..[[[..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<...............>>>>><<.<<<<<<<<<<<..>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<..<..<<<.....<<<<....>>>>.....>>>>.>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<..<<<<<<........>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<......>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))......<<<<<<<..<<<<.))))))>>>>>>>>>>>.........>>>>..>>>>>>.......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<<]]].>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((.(((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..)))).).))...)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((...........(((((((((((((((((((((((.......(((((((......((((((....)))))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...(.((((.....)))).).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.......(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((..((((((....((.....))..)))))....[[(((.((...((....(((....)))........(.(....(...).....).)....))....))...(((((........)))))]]((((.((((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....))))..)))))))).))).))).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((..)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...(......((((....))))......).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(.(..............).)....((((.....((((..((((........))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.............))))...)))).))))....)))))))).......(((.((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).)).)))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Crystal structure of Cryptopleurine bound to the yeast 80S ribosome; 25S ribosomal RNA 4u55 7 121 3.2 RF00001 URS000055688D_559292 25209664 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of Cryptopleurine bound to the yeast 80S ribosome; 5S ribosomal RNA 4u55 8 158 3.2 RF00002 URS00001BF64E_559292 25209664 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of Cryptopleurine bound to the yeast 80S ribosome; 5.8S ribosomal RNA 4u56 2 1750 3.45 RF01960,RF01959,RF00177 URS00005F2C2D_559292 25209664 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucau ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[..................<.....<<.<<<.....>>>.>>......>.........<<<<<..<......>..>>>>>....((((((......<<<<<<<<<<<....>>>..............)))))).........<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<.<<.<..........>.>>.>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.[[....<<<<<<.<<<<<....<..>....>>>>>.>>>>>>....<<<<<<...............................>>>>>>....<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>..........[[...((((((((....>>>>>>>>.))))))))..]].....]]....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<......>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<........<<........>>..........<<<<<......<<<<<........<<.<<<........>>>.>>......>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<..<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>........>>>>....>>>.>>>.....>>>>>>>>......>>>>>......>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<...>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>....... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[[[[[[[.((....))......(......).)))))).)...).(.((((.(((.(....)))))))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....((..(.((..............)).)...))......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((((............))))).))))))....((((((....(.....................)....))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(......(..(((....]]]]]]]].)))..).....).....))...(((..((..(...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)..))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.((...((((((((.(((........)))))))))))...))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((.(......((.....((..((((....))))..))....)).......).)))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...((...))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>...... Crystal structure of Blasticidin S bound to the yeast 80S ribosome; 18S ribosomal RNA 4u56 1 3149 3.45 RF02540,RF02543 URS000061F377_559292 25209664 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[...........<<.<<<<<<...>>>>>>.>>.............<<<<<<.<<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<......<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>(><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<<..<<<<<<.....>>>>>>>>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>).<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<......<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>....>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><..<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>...>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<.....<..>......>>>>><<.<<<<<<<<<<.<...>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<...<<.....<<<<....>>>>.....>>.>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<.....>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<...<<<<<<<<<<<}}}.>>>>>..>>>>>>..>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<..<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>..>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((......(((..(....)..))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...((((((.....)))))).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((.(((....(.........)....))).....(...(........).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))((((((((((.((......((((.((((....))))))))...)))))))))).)).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........(.(...(.....)....).)....))....))...(((((........)))))]]((((.((((.(((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....)))...)))))))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((((.(...)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.....((.....((((....)))).....))..))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.(.....).)))))))....((((.....((((..(((..........)))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......(((....(((.((....((.(........((((((.....)))))).....))).......((((((...(((((....(((......)))....))))).)))))).............)).)))....)))..(((((.(..(.......)..).....(((((((((.(((....((((.(..(.(.((..)..).).)..)))))...)))....)))).)))))..))))).. Crystal structure of Blasticidin S bound to the yeast 80S ribosome; 25S ribosomal RNA 4u56 3 121 3.45 RF00001 URS000055688D_559292 25209664 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of Blasticidin S bound to the yeast 80S ribosome; 5S ribosomal RNA 4u56 4 158 3.45 RF00002 URS00001BF64E_559292 25209664 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((...(.]].)..........).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of Blasticidin S bound to the yeast 80S ribosome; 5.8S ribosomal RNA 4u56 6 1795 3.45 RF01960,RF01959,RF00177 URS00005F2C2D_559292 25209664 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccucuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccgguccgauuuuuucguacuggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[[..............<.....<<.<<<.....>>>.>>......>.........<<<<<..<<....>>..>>>>>....((((((......<<<<<<<<<<<<..>>>>..............)))))).........<<<<..<<<.....>>>.>>>>..].]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<<<<..............>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.{{....<<<<<<.<<...<<<<...............>>>>.......>>.>>>>>>....<<<<<<....<<..<<<<.......>>>>..>>....>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[[..((((((((....>>>>>>>>.)))))))).]]].....}}....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<.<....>.>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<........<<........>>..........<<<<<......<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<<<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>...>.>>>>>>>.......>>>>>......>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<.<<<..<........>....>>>.>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((...............(.....((.(((.....))).))......).........(((((..((....))..)))))(.(.((((((......[[[.[[[..((....))......(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(((((.(................).)).)))......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((..((((...............))))......))).))))))....((((((....((..(((((.....)))))..))....))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(((..(.(.((((.....]]].]]].)))).).).))).....))...(((..((..(...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)..))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((......(((((........((.(((........))).))......)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).......)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...((((((..((.....(.....)......))..))))))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>........ Crystal structure of Blasticidin S bound to the yeast 80S ribosome; 18S ribosomal RNA 4u56 5 3150 3.45 RF02540,RF02543 URS000061F377_559292 25209664 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacauggcugggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<<.<<<<..<<<<<<<<<<<<<<.....<<<<......>>>>.(.......<<<......)>>>....>>>>>>>>..>>>>>>......>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<<...........<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<....<.<<<<<<....>>>>>>>......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>(><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<<..<<<<<<.....>>>>>>>>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.........>>>>.>>>>.....>>>>>.>>>>>>>>.>>).<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<......<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>....>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<<.....>.>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<.<<<<<<<<<<<..>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<..<..<<<.....<<<<....>>>>.....>>>>.>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<........>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<......>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<.}}}..>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.((((((((((((((.((((((...({((((......)))))[[(...).(((....}]])))....))))).))..)))))).))...)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((...........(((((((((((((((((((((((.......(((((((......((((((....)))))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...(.(((.......))).).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.......(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((.(..((..(((((((...((.....)).))))))....[[(((.((...((....(((....)))........(.(..(.(...)..)..).)....))....))...(((((........)))))]]((((.((((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....))))..)))))))).))).))).....((......)).).)).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((..)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...(......((((....))))......).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(.((............)).)....((((.....((((..(((((......)))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.............))))...)))).))))....)))))))).......(((.((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).)).)))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(((.((..)..).)))..)))))...)))....)))).)))))).))))).. Crystal structure of Blasticidin S bound to the yeast 80S ribosome; 25S ribosomal RNA 4u56 7 121 3.45 RF00001 URS000055688D_559292 25209664 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of Blasticidin S bound to the yeast 80S ribosome; 5S ribosomal RNA 4u56 8 158 3.45 RF00002 URS00001BF64E_559292 25209664 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<<...>>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of Blasticidin S bound to the yeast 80S ribosome; 5.8S ribosomal RNA 4u67 X 2667 3.65 RF02540,RF02541 URS000080DEF1_243230 28689968 0003735 0005840 243230 ggucaagauaguaaggguccacgguggaugcccuggcgcuggagccgaugaaggacgcgauuaccugcgaaaagccccgacgagcuggagauacgcuuugacucggggauguccgaauggggaaacccaccucguaagagguauccgcaaggaugggaacucagggaacugaaacaucucaguaccugaaggagaagaaagagaauucgauuccguuaguagcggcgagcgaacccggaucagcccaaucaagccgaaguggcuggaaagcuacaccucagaaggugagaguccuguaggcgaacgagaggucguuguucgugaaacgaugacugaauccgcgcggaccaccgcgcaaggcuaaauacucccagugaccgauagcgcauaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaagagaaccugaaaccguggacuuacaagcagucauggcaccuuaugcguguuauggcgugccuauugaagcaugagccggcgacuuagaccugacgugcgagcuuaaguugaaaaacggaggcggagcgaaagcgaguccgaauagggcggcauuaguacgucgggcuagacucgaaaccaggugagcuaagcaugaccagguugaaacccccggggggcggaggaccgaaccggugccugcugaaacagucucggaugaguuguguuuaggagugaaaagcuaaccgaaccuggagauagcuaguucuccccgaaauguauugagguacagccucggauguugaccauguccuguagagcacucacaaggcuaaaaccuuaugaaacuccgaaggggcacgcguuuaguccgggagugaggcugcgagagcuaacuuccguagccgagagggaaacaacccagaccaucagcuaaggucccuaaaugaucgcucagugguuaaggaugugucgucgcauagacagccaggagguuggcuuagaagcagccaccaagagugcguaauagcucacuggucgagugacgaugcgccgaaaaugaucggggcucaagugaucuaccgaagcuauggauucaacucgccgaguugucugguaggggagcguucaguccgcggagaagccauaccggaaggagugguggagccgacugaagugcggaugccggcaugaguaacgauaaaagaagugagaaucuucuucgccguaaggacaaggguuccuggggaagggucguccgcccagggaaagucgggaccuaaggugaggccgaacggcgcagccgauggacagcaggucaagauuccugcaccgaucauguggagugauggagggacgcauuacgcuauccaaugccaagcuauggcuaugcugguugguacgcucaagggcgaucgggucagaaaaucuaccggucacaugccucagacguaucgggagcuuccucggaagcgaaguuggaaacgcgacggugccaagaaaagcuucuaaacguugaaacaugauugcccguaccgcaaaccgacacagguguccgagugucaaugcacuaaggcgcgcgagagaacccucguuaaggaacuuugcaaucucaccccguaacuucggaagaagggguccccacgcuucgcguggggcgcagugaauaggcccaggcgacuguuuaccaaaaucacagcacucugccaacacgaacaguggacguauagggugugacgccugcccggugccggaaggucaaguggagcggugcaagcugcgaaaugaagccccggugaacggcuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaggcguaacgaucugggcgcugucucaacgagggacucggugaaauugaauuggcuguaaagaugcggccuacccguagcaggacgaaaagaccccguggagcuuuacuauagucuggcauugggauucggguuucuagaaacuuggauuucuaaccugaaaaaucacuuucggggaccgugcuuggcggguaguuugacuggggcggucgccucccaaaauguaacggaggcgcccaaaggucaccucaagacgguuggaaaucgucuguagagcgcaaagguagaagguggcuugacugcgagacugacacgucgagcagggaggaaacucgggcuuagugaaccggugguaccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagaguccauaucggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgcuacgggcgcaggagaauugaggggaguugcuccuaguacgagaggaccggagugaacggaccgcuggucucccugcugucguaccaacggcacaugcaggguagcuauguccggaacggauaaccgcugaaagcaucuaagcgggaagccagccccaagaugaguucucccacugcagguaagacucccggaagaccaccggguuaagaggccaggcgugcacgcauagcaauguguucagcggacuggugcucaucagucgaggucuugacca <<<<<<<<......<<<<<<<<<<<....<<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<...<<.))..))..>>......>>>>>>...>>>....<<<....>>><<<<<....>>>>><<<<....>>>>>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<......<<.....>>.....>>>>...<<<.......<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>........<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>..............<<....>>....>>.........<<<<....>>>>.............>....>>>>>>>>>>>.......<<<<<<<<<<.......>>>>>>>>>>...<.<........>.>.<<<<<<....<<<.<<<<<<<<<<..<<<...<<<....>>>...>>>...<<....>>...<<......>>.........>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<.....<<<<<.>>>>>......>>>...<<<..<.<<........>>.>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<...<<<..<<<<<<...<<<...<<<.<<<<......>>>>.>>>..>>.>...>>>>>>...>>>..>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<......<<<<.......>>>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><..<<<<<<...>>>>>>..>....>>>>>><.<<<<<<<.<<......<<<<<.<<....>>.>>>>>...>>.>>>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<<..>>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<...<<...<<<<....<<<<..<<<..<<<<<.<<<<.<<...[[....>>>>>><<<<<<<.<<..<<<<<<<<<<...<<.....>>.>>>>>>....>>>>..>>>>>>>>>...<<<<<....>>>>>....>>>>>...>>>...>>>>.........>>>>...>>......>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<...>>>>>>>>............<<<<<<<<<..<<...........>>..<<<<<<<.....<<<.....>>>.......>>>>>>>.<<<<<..<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<>>>>>>>>>>>>>>>...<<<<<<.......>.>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.]].>>>>>>...>>>>>...>>>>.>>>>>....<<....<<<<<...........>>>>>....>>..>>>>.......>>>>>>>..<<..>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>>>. .(.(((((......(.((((((((.....(((..(((.((((((((......((((((.[...[[.))).....((((((...((.]]...]..))......))))))...)))....(((....)))(((((....)))))((((....))))))...((((((.....(...[..)......))))).).........((....))...((((......((.]...)).....))))...(((.......(((...(((((......)))))[[(...).((......]].))...)))........((((((((.........))))))))......(((((..[[[[)))))..)))......)).)))).).))..............((....))....))......(..((((....))))............)).....)))))))).).....(.((((((((((..[....)))))))))).<.(.(........).).((((((....(((.((((((((((..(((...(((....)))...)))...((....))...((......)).........)))))))))))))..((.(...((((((.....((((((((((.((((....(((((.)))))....)<)))...(((..(.((........)).).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((..((..(.((((((...(((...(((.((((......)))).)))..)).)...)))))).)...).)))))))).))..(((((((.((......)).)))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((..((((.......(((((...(...((.........))...)..(...((......)).).)))))...))))..)))).))..........]]].)....))))))))))...)))))))(..(((((((.)))))))..)....))))))(.(((((((.((......(((((.((....))])))))...)).)))))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((((((...((...((((....(((((.(((..(((((.((((......{{......))))(((((((.((..((.(((((.(...((.....)).).))))....).))..)))))))))...(((((....)))))....)))))...)))..)))))(..).....))))...))......))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.[..).....)))))((((((((...))))))))(...).......(((((((((.>.(...........)...(((((((.....(((.....))).......))))))).]((((.(((..(((((((..((.....(...(((((....)))))...).....)))))))..))))).......((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).[..(((((.....>].)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((.(((....))).)))))))))...((((.(.......)..))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...(((...(((...{..)))...))).(((....))).))]]].].....(((((((..(..]]]]..).))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((....(((...(((((((((((.}}.))))))...)))))...)))..)))).)...((....((((.............))))....))..))))..]....)))))))(.(....).(..(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))..))))))).).. Crystal structure of the large ribosomal subunit (50S) of Deinococcus radiodurans containing a three residue insertion in L22; 23s RNA 4u67 Y 122 3.65 RF00001 URS000080E04E_243230 28689968 0003735 0005840 243230 cacccccgugcccauagcacuguggaaccaccccaccccaugccgaacugggucgugaaacacagcagcgccaaugauacucggaccgcagggucccggaaaagucggucagcgcggggguu .<<<<<<<<<<.....<<.<<<<<....<<<<<<<.............>>>>..>>>...>>>>>..>><<<.......<<.<<<<<....>>>>>.>>.......>>>..>>>>>>>>>>. .((((((((((.....((.(.(((....(((.((....(.....)....))...)))...))).)..))(((.......((.(((((....))))).)).......)))..)))))))))). Crystal structure of the large ribosomal subunit (50S) of Deinococcus radiodurans containing a three residue insertion in L22; 5s RNA 4u6f 2 1781 3.1 RF01960,RF01959,RF00177 URS00005F2C2D_559292 25209664 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucau ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[..................<.....<<.<<<.....>>>.>>......>.........<<<<<..<......>..>>>>>[...((((((......<<<<<<<<<<......>>..............)))))).....]...<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<.<<..<.<..........>.>..>>..>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.[[....<<<<<<.<<<<<....<..>....>>>>>.>>>>>>....<<<<<<...........<.......>...........>>>>>>....<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>..........[[...((((((((....>>>>>>>>.))))))))..]].....]]....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<......>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<.......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<<<......>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>>....>.>>>>>....>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<......<<<<<<<.<<...<.........>....>>.>>>>>>>......>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>....... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[[[[[[[(((....))).....(......).)))))).)...).(.((((..((.......)).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....((..(.((....(....)....)).)...))......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((((.....().....))))).))))))....((((((...............................))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(......((.(((....]]]]]]]].))).)).....).....))...(((..((..(...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)..))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...((.(((..(....................)..))).))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>...... Crystal structure of T-2 toxin bound to the yeast 80S ribosome; 18S ribosomal RNA 4u6f 1 3149 3.1 RF02540,RF02543 URS000061F377_559292 25209664 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<<.<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<......<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<....<....>....>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<<....>>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<......>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<...<<.....<<<<....>>>>.....>>.>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<.....>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<.}}}..>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<..<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>..>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((......((((.(....).)))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...((((((.....)))))).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((.(((...((.........))...))).....(...(........).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........((....(.....).....))....))....))...(((((........)))))]]((((..(((.(((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....)))...))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((((.(...)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.....((.....((((....)))).....))..))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.........)))))))....((((.....((((..((((........))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......(..(.(.((((((...((.......))...))))))...))...)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......((((...(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((....(((......)))....))))).)))))).............)).)))...))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Crystal structure of T-2 toxin bound to the yeast 80S ribosome; 25S ribosomal RNA 4u6f 3 121 3.1 RF00001 URS000055688D_559292 25209664 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of T-2 toxin bound to the yeast 80S ribosome; 5S ribosomal RNA 4u6f 4 158 3.1 RF00002 URS00001BF64E_559292 25209664 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of T-2 toxin bound to the yeast 80S ribosome; 5.8S ribosomal RNA 4u6f 6 1795 3.1 RF01960,RF01959,RF00177 URS00005F2C2D_559292 25209664 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccucuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccgguccgauuuuuucguacuggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[...............<.....<<.<<.......>>.>>......>.........<<<<<..<<....>>..>>>>>[...((((((......<<<<<<<<<<<<..>>>>..............)))))).....]...<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<<<<...<......>...>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.{{....<<<<<<.<<<..<<<<...............>>>>......>>>.>>>>>>....<<<<<<....<<..<<<<.......>>>>..>>....>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[[..((((((((....>>>>>>>>.)))))))).]]].....}}....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<......>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<......<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<......>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>.......>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<.<<<..<........>....>>>.>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((...............((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[[.[[[...(....).......(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(.(((.(................).)).).)......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((..((((...............))))......))).))))))....((((((....((..(((((.....)))))..))....))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(((..(.((((.(.....]]].]]].).)))).).))).....))...(((..((..(...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)..))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((........((.(((........))).))......)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...(((((((.((.....(.....)......)).)))))))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>........ Crystal structure of T-2 toxin bound to the yeast 80S ribosome; 18S ribosomal RNA 4u6f 5 3150 3.1 RF02540,RF02543 URS000061F377_559292 25209664 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacauggcugggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<.<<<<<.<.<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>..>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<<...........<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<<..<<<<<<.....>>>>>>>>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>>..<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<<.....>.>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<...............>>>>><<.<<<<<<<<<<<..>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<..<<<.....<<<<....>>>>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<........>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<......>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<..<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<.<..<<<<<......>>>>>..>>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((.(((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..)))).).))...)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((...........(((((((((((((((((((((((.......(((((((......((((((....)))))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...(.((((.....)))).).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.......(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((..((((((....((.....))..)))))....[[(((.((...((....(((....)))........(((..(.(...)..)..)))....))....))...(((((........)))))]]((((..(((((.(...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....).))..))).)))).))).))).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((((....))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...(......((((....))))......).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(.((............)).)....((((.....((((..((((........))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......(..(.(.((((((...((.......))...))))))...))...)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.............))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Crystal structure of T-2 toxin bound to the yeast 80S ribosome; 25S ribosomal RNA 4u6f 7 121 3.1 RF00001 URS000055688D_559292 25209664 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of T-2 toxin bound to the yeast 80S ribosome; 5S ribosomal RNA 4u6f 8 158 3.1 RF00002 URS00001BF64E_559292 25209664 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of T-2 toxin bound to the yeast 80S ribosome; 5.8S ribosomal RNA 4ug0 L5 3776 3.6 RF02543,RF02540 URS000086853A_9606 25901680 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcggcccggcggaucuuucccgcgcgggggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucggccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcgcucuccccccucccggcgccgccggggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccgggggaggggccacgcgcgcgucccccgaagagggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcacacgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcgugagccgggcguggaauggagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagcggcgggggcggcgcgcgcgcgcgcccgcccccggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcugggucggucgucggccggcgccuagcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacaugagagguguagaauaagugggaggcccccggcgcccccccgguguccccgcgaggggcccggggcgggguccgccggcccugcgggccgccggugaaauaccacuacucugaucguuuuuucacugacccggugaggcgggggggcgagccccgaggggcucucgcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccggucccccgcgggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcacgccguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu ..........................<<<<<.....<......>......>>>>>...........<<....>>..<<<<<<.....<<.....>>....>>>>>>..[[[..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>>..<<<<<<<<<......<<<<<.........<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>....>>>>>.....>>>>>>>>>.......<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<......>>>..................................<<<<<<<<..<<<.......<<<<.<<.<<<.....<<<<<<<<<<<...<<<.<<..<<<<......<<<<<.<<....<......>..>>>>>>>.>.>>>.>>....>>>.>>>>>>>>>>>......>>>.>>..>>>>...<<<<<<<<.<<<<<<<<<..<<<........<...<<.<<<.......<<<<....>>>>........>>>.>>..>...........>>>....>>>>>>>>>....................<<.....<<<<<.<.............>.>>>>>...<.<<....<..<<<<<<<<<.<<<<.<<<<<<..<...........>...>>>>>>.>>.>>.>>>>>>>.>>....>......>>.>.........<<<<<.........>>>>>............>>......>>>.>>>>>....>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<......>>>>>>>..<<<<<...<<<..<<<.....{..[[.>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<............<<<<<<<<....<<<....<<...<.<<<....<<.............>>..>>>.>...>>..>>.>....>>>>>>...<<<<<<<<<........>>>>>>>>>...>>...>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<......<..........<<<.<<<<<<<<<........<<<<....................................<........>....>>>>....>>>>>>>>>>>>..........))).>....>>>>>..>>>...>>>>>>><<<<<<.<<<..........]]...}.......................................................>>>>>>>>>....>>>>>>..<<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>.>......>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<.<...........>.>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<.....<<<<<<<....>>>>>>>...<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..{{{..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>.............>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<...............<<<<<....<....>.....>>>>><<.<<<<<<<<<<<......<.....>...........>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.....<<.....<<<<....>>>>.....>>..>>>>..>>>>>.<<............>.>.........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<<.<<<<<<.<..<<............................<.........<.<.....<.......>....>.>....>............................................>>....>>>>>>>...<<<<<.....<<<<.....<<.<<......>>.>>................<<<<<<<<<.........>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>>.<<<....>>>.>>)))]......((((((..(((..>>>>>>.)))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]].....<<<<<<.<..<<<....<<<<<.................>>>>>..<<<<....<<<<....<<.<<<<<<.}}}..>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.....<<<<<<......<<<.....<<.........<<<<<..<.<<..>>>..>>>>>........>>....<<...<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>...>>..............>>>.....>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<.<..<<<<<......>>>>>..>>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..(((((.(((((.....)))))..))))....))))....(.(((..((.....((((.((...(....((((((((..({((.(......).)))....[[(...).(((....}]])))...).))))))))..)).)).))...).).))).)..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((.(....).))............).....................((((((((..(((.......((((..............(((((((((...((...(..((...(....((((..((....(.......).)).)))).)..)).)......).))))))))))................))))...((((((((.((((.(((((.(((....(...(.(.((.(((.......(((.(..).)))........))).)).)).........).)))...))))).))))....................(((.(...((((......(.....)....)))).......(..(.(..((.(((.((.(.(((((((((..................))))))))..)).)).)))..))....)..)...)..............(((.........)))...........).)))......))).)))))....)))...)))))))).[((((........))))((((((....(((((((((((((..(((..(((((........)))).)...)))...((....)).....(((.(......).)))....(((((...((...((....[.[...[..))...))....))))).(((((((((..(((......))).))))))).))....)))))))))))))..((.(...((((((.....(((((((((..((.....(((((((....)))))))....<.))...(((..((.((........)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((............(.((((((....(((....(((..(.(((.......................))).)..)))..)).)....))))))...(((((((((........)))))))))....)...)))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(...(((((......(..........(((.(((((((........{...(.(....................................(......).....))........))))))))))..........]]].)....))))).))))...)))))))((((((.(((..........]....]]......................................................)))))))))....)))))).(.((((((((.((......(((..((((....)))).)))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...((....(((....)))..........((.((((.............))))))......))....))...(((((........)))))]]((((....(((......((((((....))))))...((((....))).......((((((...((((((((((((((((.((((((..{{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....(((((((.......))))))).))).).))))))))))))(...)....))))))....)............))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((........................)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.....(......((((....))))......)..))))..))))).((.............)).........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.(.......((((.(((.((..(((((.(((((((((.(((.((((...(...((.....................................................................................................))...)....)))).)))...(((((.....((((.....((............))................((((.(.((.........)).).))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....)).)..)))))).......((.(.(..(((((...((.......))...)))))....)).).)........((((.((((((..(.(.((((........))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).)))).....)..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(.(((((}}}.)))))...).))...))))...)))).(((....((((.....}.......))))....)))..)))...).)))))).......((((........(.....((..........((((.............)))).........))....(....(((....((...(((((((......)))))))..))...)))....)..............).......))))..(((((.(..(.......)..)....((.(((((((.((.....((((.(..(((((......)))))..)))))....))....)))).))).))..))))).. STRUCTURE OF THE HUMAN 80S RIBOSOME; 28S ribosomal RNA 4ug0 L7 120 3.6 RF00001 URS00000F9D45_9606 25901680 0003735 0005840 9606 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. STRUCTURE OF THE HUMAN 80S RIBOSOME; 5S ribosomal RNA 4ug0 L8 156 3.6 RF00002 URS0000005270_9606 25901680 0003735 0005840 9606 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<.<<.....>>>.....(.<<<......>>.............>>>..)...>>>....<<....>><<<<<<<<.......>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))((((((((.......)))))))).................... STRUCTURE OF THE HUMAN 80S RIBOSOME; 5.8S ribosomal RNA 4ug0 S2 1742 3.6 RF01960,RF01959,RF00177 URS0000868520_9606 25901680 0003735 0005840 9606 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucgcuccucucccacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgccccccguggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuccgcgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcgggcguccccgccgccucucggccggggcccgaagcauuuacuuugaaaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggucggcccacggcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<.........<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<......<<....<<<....................<<.....<<.<<.......>>.>>......>>.........<<<<...<<<<........>>>>...>>>><...<<<<<...<......>..>>>>>........>..<<<<..<<........>>.>>>>....>>>...>>....>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>..>>>......>>.>.....<<.<<.<<..............>.>.>>..>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<..((.....<.<<...<<<.<<.................................................<<<<<.<.......<<...<.......>..<<<.......>>>....>>......>.>>>..>>........<<.<..<<..<<.................>>..>>..>>>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>.>.>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>...>.<<<......<<<......>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<........<<........>>........<.<<<.........<<<<............<<........>>..........>>>>....<<.<<<..<<.<<.<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<...<............<<......>>............>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>..>>.....>>>>>>>.........>>>>.....>>>>.>>>.....<<.<<<................<<<.<<<<....>>>>.>>>..............>>>.>>......<..<<.<<<<<..........>>>>>>>...>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<..<<....<<<<<<<<.<<<..<<<<.<<...<<<<<.................................>>>>>...>>.>>>>..>>>.>>>>>>>>...>>..>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))(((.((.(((...(.((..((.....(((.(.(..((....((....((..........))...))[))......(((.......(((.(.(..((....(((((.........................((.(((.....))).))..................(((...((((........))))...))).....(((((...(......)..)))))...........((((...((......))..)))).)).)))...))).).))).(((....(((....((((((...........)))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...).)))).).....(.(((...((((.]...))).))))).)...)).).....(...(.....................)....).......(.................)..........((((([[......((((.....((..]])).......)))).)))))..))).)).)))..[......(..[[...(.(.((...(((..(................................................((((((.(........(...(.......)..(((.......)))....).......).)))..))).......((....(.....(................)....)...))....)....(((.((...(...((((..((..((((((((...((........))......))))))))..)).......((....))...))))..)...))..))..))))...)).)....((((((........((((.........)))).....))))))......{...(((.((.(((..(.((((((.(((........))))))))).)..)))...((.].]))...))...].))))..).(((......((((....))))....)))...]]].]((.((.(((((((..((..(((((..(((.((((((......((........))..........(.....(....(................(..........)..............)...((.(((...(.((.(((....(((.(((((....)))..(.((......)))...)).)))....((....(.....((..................(....).................))....).....(((((.....))))).........))....)))..)).....).))))).....).....)...)).)))).))).(...((.((.........(........((.((((....)))).)).....)..........)).))......(.....(((((..........))))).....)..)..))))).....(..(((((.......)))))..)......))...)))))))))..))..(.(..((.(..(((..((..(.((((((((.(((..(.((.((...((((...................................))))...)).)).)..))).)))))))))..))..)))...).))...)..)..(((((((((....)))))))))}........ STRUCTURE OF THE HUMAN 80S RIBOSOME; 18S ribosomal RNA 4ug0 S6 75 3.6 RF00005 URS0000326EAC_9606 25901680 0030533 0006412 9606 agcagaguggcgcagcggaagcgugcugggcccauaacccagaggucgauggaucgaaaccauccucugcuacca <<<<<<<..<<<<.......>>>>.<<<...........>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((...........)).(((...........))).....(((((.......)))))))))))).... STRUCTURE OF THE HUMAN 80S RIBOSOME; HUMAN INITIATOR MET-TRNA-I 4ujc AA 76 9.5 RF00005 URS00005AA258_9986 25064512 0030533 0006412 9986 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... ((((..(..((((.....[..)))).(((((.......))))).....(((((..]....))))))..)))).... mammalian 80S HCV-IRES initiation complex with eIF5B POST-like state; TRNA 4ujc AC 261 9.5 RF00061,RF00620 URS000080E1FF_11103 25064512 0043022 0006417 11103 ccugugaggaacuacugucuucacgcagaaagcgucuagccauggcguuaguaugagugucgugcagccuccaggacccccccucccgggagagccauaguggucugcggaaccggugaguacaccggaaugauuugggcgugcccccgcaagacugcuagccgaguaguguugggucgcgaaaggccuugugguacugccugauagggugcuugcgagugccccgggaggucucguagaccgugcaccaugagcacgaau .<<<.<<<<.....<<<<...<<<.<<....<<<<<.......>>>>>.....>>.>>>....>>>>>>>>>>>.......<<<<<<<<<<<.<<<<<<<<<<<<.<<<<..<<<<<<....>>>>>><<...>>.<<<....>>>>>>>..>>>>>>>><<<.....<<<......>>>....>>>....>>>>.>><<<<....>>>><<.((((((.>>>>>>>>>>>.))))))....................... ((((.((((.....(((.....((.((....(((((.......))))).....)).))......)))))))))))......(((((((((((..((((((.(((((((((..((((((....))))))(((.))).(((....))))))).))))).)))(((.....(((......)))....)))....)))..))((((....))))((.[[[[[[.))))))))))).]]]]]]....................... mammalian 80S HCV-IRES initiation complex with eIF5B POST-like state; HCV-IRES 4ujc A2 3616 9.5 RF02543,RF02540 URS000043B91E_9986 25064512 0003735 0005840 9986 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggccggcgcgcgcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcggcccggcggaucuuucccgcgcgggggaccgucccccggaccggcgaccggccgccgccgggcgcauuuccaggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucgggggcccccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcgcucuccccccucccggccccccggggggggccgggccaccccucccacggcgcgaccgcucucccaccccuccucccgggucggggggcggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccgggggagguucucucggggccacgcgcgcgucccccgggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgaggggcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcuccaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcacugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggaggccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcugggugcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacaugagagguguagaauaagugggaggcccgggccgccggugaaauaccacuacucugaucguuuuuucacugacccggugaggcgggggggcgagcccgaggggcucucgcuucuggcgccaagcgcccgcccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucgccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcgaacgauacggcagcgccgcggagccucgguuggccucggauagccggucccccgccuguccccgccggcgccgcgcgccgggaccgggguccggugcggagugcccuucguccugggaaacggggcgcggccggaaaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuu .........................<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..[[[..<.......<..<<....<.....>....>>..>.......>..<<<<<<<<.......<<.<<<.<<<.......<<<<.....<<<<......>>>>.....((......<<<.....))>>>.....>>>>>>>>>>>>....>>>>>>>>.......<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>................<.......>....................................<<<<<<<<..<<<......<<<<<.<<<<.........<<<<<<<......<<<<..<<<<.<<<.<<<<.<<<<.<<<<<<<<>>>>>>>>..>>>>.>>>>.>>>.>>>>.>>>>>>>>>>>.......>>>>.>>>>>..<<<<<.<<..<<<<<<<.<..<<<.<.........<<.<<<.....<<.<<<<<<<..>>>>>>>...>>....>>>.>>...........>.>>>.....>>>>>>>>..............<<.<<<..<<<<.....<<....<<<<<<<<<..>>>>>>>>>...<.<<<<<.<<<<<<<<<<<<<<.<........<<<.<.<<..>>..>>>>...<<<<<<.<<<......>>>.>>>>>>.>.>.>>>>>>>>>>>.>>....>>>>>.>.........>>......<<<.<<<<<<<..>>>>>>>>>>.>>>>.>>>..>>...>>..>>>>>....>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<<....>>>>>>>>..<<<<<..<<<<..<<<...........>>>..>>>>..>>>>>.<<<<<<<<<.<<<........>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<......<<<....>>>..<<.<<<<<<.<<.<<<<<<<<....<<<....<<<....<<<..<<<<.<.........>.>>>>>>>....>>>..>.>>....>>>>>>....<<<<<<<<.........>>>>>>>>....>>>>..>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<......<..........<<<.<<<<<<<<<........<<...>>....>>>>>>>>>>>>..........))).>....>>>>>..>>>...>>>>>>><<<<<<.<...>.>>>>>>....>>>>>>...<<<<<<<..<<......<<<<.<<<<....>>>>>>>>....>>.>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<<<<<...>>>>>>>>>>>......>>....>>...<<<<<........>>>>>))<<<<..<<.......<<<<<<<<....>>>>>>>>..<<<....>>>......<<<<<<<...<<<<<<<<<<<<<<<<<<<<<<<..{{{..>>>>>>.....<<<<..<<<.<<<<.....<<<.....>>>.....>>>>>>>...>>>>......<<<<<<<.......>>>>>>>>>>>.>.>>>>>>>>>>>>.........>>>>>>>................>>..>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<...............<<<<<...............>>>>><<.<<<<<<<<<<......>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>>.<<<<.........>>>>.........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{.[[[[..<<<<<.<<<<<<<<<.<<<<<<<<<<.<.<<<<..........<<<<<..<<<<..>>>>............>>>>>.>>>>.>..>>>>>>>>>>...<<<<<......<<<.....<<<.<.....>.>>>................<<<<<<<......>>>>>>>..>>>...>>>>>....>>>>>>>>>..>>>>>....<<.....>>...<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>>.<<<....>>>.>>)))]......((((((..(((..>>>>>>.)))))))))..........]]]]...}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]].....<<<<<<....<<<....<<<<<.................>>>>>..<<<<....<<<<....<<.<<<<<<.}}}..>>>>..>>.>>...>>>>...>>>>.<<<<...<<<<<...........>>>>>...>>>>..>>>....>>>>>>.....<<<<<<<.<<..<<<.<...<<<.........<<<<.<<<....<<.....<<<<<<..>>>.>>>..>>.....>>>.>>>>........>>>...<<<..<<<.....<<<<.<<<<<<<......>>>>>>>>>>>....>>>..>>>.............>.>>>..>>>>>>>>>.<<<<.....................<.<<<<<<<.<<.....<<<<....<<<<<......>>>>>...>>>>....>>....>>>>.>>>.>..>>.>>. .........................(((((......(......).......)))).).........((....))...((((......((.....)).....))))...(((.............((...............)).............((((((((..........(((.((........((((.....(((........))).....[.(...).(((......]))).....)))).)))))......)))))))).......((((((..........))))))......(.((..[[[..[)).)...)))..................................((....))............(..((.(....).))............).....................(((((((...(((.......((((.(((........(.(((((((......(((((.((((.((..((((.(((..(..((((()))))..)...))).))))..)).)))))))))))))))).)......))).))))....((((((..(.((.(((.(.(((..((......(.((.((((....(..(((((((())))))))....)...)))).)).)........))..)))...).))).)).)..............(((((..(.(.....(((..((.((((((((..)))))))).)).(.(.((((..(.((((((((((.((......(((.(..((()))..).)))..((.(((.((........)).))).)))).).))))))))).)...)...))).).).........)))......((.(((((((())))))))))...).).))).)).....).))))).....)))....)))))))..((((........))))((((((....(((((((((((((..(((...((((........)))).....)))...((....))...((((((((....))))))))...((((...(((..(((...........)))..)))...))))..((((..(((.((((......)))))))..)).))....)))))))))))))..((.(...((((((.....(((((((((..((.....(((((((....)))))))......))...(((..((.((.......{)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((.(..((.(((((((.....(((.....((..(.(((...(.....(.....).....).))).)..))...)).).....))))).....(((((((.(......)))))))).....))))...).)))..))..((((.(((((.....))))).))))....(((......)))...((((.((...((([[[.....(.(((((......(..........(((.((((((((((........(...)....)))))))))))))..........]]].)....)))))).)))...)).))))(((((.........)))))....)))))).(.(((((((..((.......(((.((((....))))))).....)).)))))))..).....)))))).(......(.....((((((.......)))))).(((.....((((..((..(((((((...((.....)).))))))....[[(((.((...(.....(((....)))..........((.(((..(.((...)).)..))))).......)....))...(((((........)))))]]((((..((..(....(((.(((......))).))).((((....)))...(...(((((....(((.(((.((((((((((.(((.........))).)......(...((((.((((.....(((.....))).....))))))))....).......(((((((.......))))))))))).).)))).))).)))(...).....)))))...))..........).))..)))).))).))).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((....)))))..)))))).))(...).......(((((((((...((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(...((.....((((....)))).....)).)))))..))))).((.(.........).).)........((..........((((.........))))..)..)....)))....)).))))))).)..))).)))))))..))))).....)..[..(((((......].)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((.(.((((.(((...........(((((..((((()))))............)))))..))).)).)).).)))))....((((.......((.....((((((...))))))................(((((((......)))))))...))...))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((...((((((.......)))))).....((]..[[[))....)))))))...(((..((((.......))))..))).((......)).))]]].......((((((..(((..]..]]].)))))))))....).....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).).......(((((.(..(((..(...(.(((......))).).....).(((.(.....).))).....)))....)...))).))....(((((((....))).))))..}.))..))).)))))......(.(((....(((....(((((......(....).....)))))..((((....((((....(..(.(((((....)))))...)..)...))))...)))).((((...((((.............))))...))))..)))....))).)......((((((..((..((.(....(((.........((((.((((..((.(....((((((()))).))).).))...)))).))))........)))....((...(((....((((.(((((((......)))))))))))...)))...))...............).))..)).)))))).((((....(.......)........(.(((((((..(.....((((.(..(.((........)).)..)))))....).....)))).))).)..)).)). mammalian 80S HCV-IRES initiation complex with eIF5B POST-like state; 28S RIBOSOMAL RNA 4ujc A3 157 9.5 RF00002 URS000080DE76_9986 25064512 0003735 0005840 9986 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>.............>>>..)...>>>....<<<..>>><<<<<<<<<.....>>>>>>>>>..................... .........................................((((((.[[....[)))...].(.((((.....]]...........).)))..)...)))....(((..))).((((((((.....))))))))...................... mammalian 80S HCV-IRES initiation complex with eIF5B POST-like state; 5.8S RIBOSOMAL RNA 4ujc A4 119 9.5 RF00001 URS00000F9D45_9986 25064512 0003735 0005840 9986 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcu .<<<<<<<<....<<<<<<<<.....<<.<<..............>>...>>....>>>>>>.>>.<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>.>>>>>>>>.. ((.((..(.....((((((((.....((......................))....)))))).)).((.(((.....((.((..((....)).)).))....))).))..)..)).).) mammalian 80S HCV-IRES initiation complex with eIF5B POST-like state; 5S RIBOSOMAL RNA 4ujc C1 1742 9.5 RF01960,RF01959,RF00177 URS00005A14E2_9986 25064512 0003735 0005840 9986 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucgcuccucucccacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucagaucaaaaccaacccguagauaaccucgggccgaucgcacgccccccguggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcgcgccccuugccucucggcgcgcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggucggcccacggcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<..{.[[[[.>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<...<<<.....................>>>>>......<<........<<<......<<....<<<......................<....<<.<<.......>>.>>......>...........<<<...<<<<<......>>>>>...>>>.....<<<<<........((((((.....>>>>>...........<<<<..<<<......>>>.>>>>....>>>...>>....>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<<<<<<....>>>>...>>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....<<<<<<<<<.<<<....>>>..>>>>>.>>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<[[.....<.<<...<<<.<<....<<<.<<<>>>>>>.......<<<<.<..>>>>>.....<<<<<..<.......<<...<.......>..<<<.......>>>....>>......>..>>..>>>..........<<.<<<<<<<.....))))))....>>>>>>>.>>......>>....<<<<<<......<<<<..<<..<<<<<<<....<<<......>>>.......>>>>>>>..>>.......<<....>>...>>>>.....>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<....<<<<<<.<<<<......>>>>>>>>>>....>>>...<<..]]>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..]]]].}<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<........<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<...<.<<....<<...<<<<....>>>>..>>....>>.>...>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.....>.>>>>>......>>>>.>>>.....<<.<<<................<<<.<<<<....>>>>.>>>..............>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<.<<<<<<<<<<<<.....>>>>>>>>>>>>...>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>.........<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..)))).((.(((.((...(.....((.....(((.(((..(....(((.....................))).)......(((.......(((...(..(.....(((......................(....((.(((.....))).))......)...........(((...((.(((....))).))...))).....(((((.......[[..[[[.....))))).............((.(.((......)).)))......)))....))...))).(((....(((....(((((((.........))))))))))......)))....((.((((....))))....)).))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.....))).))))).)......).....((.((((((.(((....)))..))))).).))......(...(...........)...).........((((([[......((((.....((..]])).......)))).)))))..)).))).))...{......(.({{.....(.((....((.(......((.((()))))........((((.(())))))........(((.(.......((..(.........).(((.......)))....))......).)))................(.(.((((......]]]...]]...)))).).)........)...(((.(((..(...((((..((..((((((.(...((........))......).))))))..)).......((....))...))))..)..)))..))..)))....)).)....((((((....(...((.(.........).))...).))))))......<...(((.((..((..(.((((((.((..........)))))))).)..))....((..}}))...))...}.))).).)..((......((((....))))....))....]]].](.(((.(..(((...((..(((((..(((.((((((.......(........)...........(((((.(....((((.........((..((........))..)).......))))...((.(((..((.((((((....(((.(((.(....).)....((......))....)).)))....(((...(.(.(((...((.(....(((...(((....)))..)))....).))...)))).).....((((.......))))........)))....))).))).....))))))).....).)))))...)).)))).))).(...((.(((........(.......(((.(.((....)).).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....((.((..(.......)..)).))......))....).)).))))..)..(.(..((.(..((((.((..(.((((.(((.(((..(.((..(...((.((.(((((.(((.((.....)).))).)))))...)).))...)..)).)..))).))).)))))..)).))))...).))...)..)..(((((((((....)))))))))>........ mammalian 80S HCV-IRES initiation complex with eIF5B POST-like state; 18S RIBOSOMAL RNA 4ujd A2 3616 8.9 RF02543,RF02540 URS000043B91E_9986 25064512 0003735 0005840 9986 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggccggcgcgcgcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcggcccggcggaucuuucccgcgcgggggaccgucccccggaccggcgaccggccgccgccgggcgcauuuccaggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucgggggcccccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcgcucuccccccucccggccccccggggggggccgggccaccccucccacggcgcgaccgcucucccaccccuccucccgggucggggggcggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccgggggagguucucucggggccacgcgcgcgucccccgggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgaggggcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcuccaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcacugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggaggccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcugggugcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacaugagagguguagaauaagugggaggcccgggccgccggugaaauaccacuacucugaucguuuuuucacugacccggugaggcgggggggcgagcccgaggggcucucgcuucuggcgccaagcgcccgcccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucgccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcgaacgauacggcagcgccgcggagccucgguuggccucggauagccggucccccgccuguccccgccggcgccgcgcgccgggaccgggguccggugcggagugcccuucguccugggaaacggggcgcggccggaaaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuu .........................<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..[[[..<.......<..<<....<.....>....>>..>.......>..<<<<<<<<.......<<.<<<.<<<.......<<<<.....<<<<......>>>>.....((......<<<.....))>>>.....>>>>>>>>>>>>....>>>>>>>>.......<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>................<.......>....................................<<<<<<<<..<<<......<<<<<.<<<<.........<<<<<<<......<<<<..<<<<.<<<.<<<<.<<<<.<<<<<<<<>>>>>>>>..>>>>.>>>>.>>>.>>>>.>>>>>>>>>>>.......>>>>.>>>>>..<<<<<.<<..<<<<<<<.<..<<<.<.........<<.<<<.....<<.<<<<<<<..>>>>>>>...>>....>>>.>>...........>.>>>.....>>>>>>>>..............<<.<<<..<<<<.....<<....<<<<<<<<<..>>>>>>>>>...<.<<<<<.<<<<<<<<<<<<<<.<........<<<.<.<<..>>..>>>>...<<<<<<.<<<......>>>.>>>>>>.>.>.>>>>>>>>>>>.>>....>>>>>.>.........>>......<<<.<<<<<<<..>>>>>>>>>>.>>>>.>>>..>>...>>..>>>>>....>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<<....>>>>>>>>..<<<<<..<<<<..<<<...........>>>..>>>>..>>>>>.<<<<<<<<<.<<<........>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<......<<<....>>>..<<.<<<<<<.<<.<<<<<<<<....<<<....<<<....<<<..<<<<.<.........>.>>>>>>>....>>>..>.>>....>>>>>>....<<<<<<<<.........>>>>>>>>....>>>>..>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<......<..........<<<.<<<<<<<<<........<<...>>....>>>>>>>>>>>>..........))).>....>>>>>..>>>...>>>>>>><<<<<<.<...>.>>>>>>....>>>>>>...<<<<<<<..<<......<<<<.<<<<....>>>>>>>>....>>.>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<<<<<...>>>>>>>>>>>......>>....>>...<<<<<........>>>>>))<<<<..<<.......<<<<<<<<....>>>>>>>>..<<<....>>>......<<<<<<<...<<<<<<<<<<<<<<<<<<<<<<<..{{{..>>>>>>.....<<<<..<<<.<<<<.....<<<.....>>>.....>>>>>>>...>>>>......<<<<<<<.......>>>>>>>>>>>.>.>>>>>>>>>>>>.........>>>>>>>................>>..>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<...............<<<<<...............>>>>><<.<<<<<<<<<<......>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>>.<<<<.........>>>>.........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{.[[[[..<<<<<.<<<<<<<<<.<<<<<.<<<<...<<<<..........<<<<<..<<<<..>>>>............>>>>>.>>>>....>>>>.>>>>>...<<<<<......<<<.....<<<.<.....>.>>>................<<<<<<<......>>>>>>>..>>>...>>>>>....>>>>>>>>>..>>>>>....<<.....>>...<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>>.<<<....>>>.>>)))]......((((((..(((..>>>>>>.)))))))))..........]]]]...}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]].....<<<<<<....<<<....<<<<<.................>>>>>..<<<<....<<<<....<<.<<<<<<.}}}..>>>>..>>.>>...>>>>...>>>>.<<<<...<<<<<...........>>>>>...>>>>..>>>....>>>>>>.....<<<<<<<.<<..<<<.<...<<<.........<<<<.<<<....<<.....<<<<<<..>>>.>>>..>>.....>>>.>>>>........>>>...<<<..<<<.....<<<<.<<<<<<<......>>>>>>>>>>>....>>>..>>>.............>.>>>..>>>>>>>>>.<<<<.....................<.<<<<<<<.<<.....<<<<....<<<<<......>>>>>...>>>>....>>....>>>>.>>>.>..>>.>>. .........................(((((......(......).......)))).).........((....))...((((......((.....)).....))))...(((.............((...............)).............((((((((..........(((.((........((((.....(((........))).....[.(...).(((......]))).....)))).)))))......)))))))).......((((((..........))))))......(.((..[[[..[)).)...)))..................................((....))............(..((.(....).))............).....................(((((((...(((.......((((.(((........(.(((((((......(((((.((((.((..((((.(((..(..((((()))))..)...))).))))..)).)))))))))))))))).)......))).))))....((((((..(.((.(((.(.(((..((......(.((.((((....(..(((((((())))))))....)...)))).)).)........))..)))...).))).)).)..............(((((..(.(.....(((..((.((((((((..)))))))).)).(.(.((((..(.((((((((((.((......(((.(..((()))..).)))..((.(((.((........)).))).)))).).))))))))).)...)...))).).).........)))......((.(((((((())))))))))...).).))).)).....).))))).....)))....)))))))..((((........))))((((((....(((((((((((((..(((...((((........)))).....)))...((....))...((((((((....))))))))...((((...(((..(((...........)))..)))...))))..((((..(((.((((......)))))))..)).))....)))))))))))))..((.(...((((((.....(((((((((..((.....(((((((....)))))))......))...(((..((.((.......{)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((.(..((.(((((((.....(((.....((..(.(((...(.....(.....).....).))).)..))...)).).....))))).....(((((((.(......)))))))).....))))...).)))..))..((((.(((((.....))))).))))....(((......)))...((((.((...((([[[.....(.(((((......(..........(((.((((((((((........(...)....)))))))))))))..........]]].)....)))))).)))...)).))))(((((.........)))))....)))))).(.(((((((..((.......(((.((((....))))))).....)).)))))))..).....)))))).(......(.....((((((.......)))))).(((.....((((..((..(((((((...((.....)).))))))....[[(((.((...(.....(((....)))..........((.(((..(.((...)).)..))))).......)....))...(((((........)))))]]((((..((..(....(((.(((......))).))).((((....)))...(...(((((....(((.(((.((((((((((.(((.........))).)......(...((((.((((.....(((.....))).....))))))))....).......(((((((.......))))))))))).).)))).))).)))(...).....)))))...))..........).))..)))).))).))).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((....)))))..)))))).))(...).......(((((((((...((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(...((.....((((....)))).....)).)))))..))))).((.(.........).).)........((..........((((.........))))..)..)....)))....)).))))))).)..))).)))))))..))))).....)..[..(((((......].)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((.((.....(((...........(((((..((((()))))............)))))..))).....).).)))))....((((.......((.....((((((...))))))................(((((((......)))))))...))...))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((...((((((.......)))))).....((]..[[[))....)))))))...(((..((((.......))))..))).((......)).))]]].......((((((..(((..]..]]].)))))))))....).....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).).......(((((.(..(((..(...(.(((......))).).....).(((.(.....).))).....)))....)...))).))....(((((((....))).))))..}.))..))).)))))......(.(((....(((....(((((......(....).....)))))..((((....((((....(..(.(((((....)))))...)..)...))))...)))).((((...((((.............))))...))))..)))....))).)......((((((..((..((.(....(((.........((((.((((..((.(....((((((()))).))).).))...)))).))))........)))....((...(((....((((.(((((((......)))))))))))...)))...))...............).))..)).)))))).((((....(.......)........(.(((((((..(.....((((.(..(.((........)).)..)))))....).....)))).))).)..)).)). mammalian 80S HCV-IRES initiation complex with eIF5B PRE-like state; 28S Ribosomal RNA 4ujd A3 157 8.9 RF00002 URS000080DE76_9986 25064512 0003735 0005840 9986 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>.............>>>..)...>>>....<<<..>>><<<<<<<<<.....>>>>>>>>>..................... .........................................((((((.[[....[)))...].(.((((.....]]...........).)))..)...)))....(((..))).((((((((.....))))))))...................... mammalian 80S HCV-IRES initiation complex with eIF5B PRE-like state; 5.8S Ribosomal RNA 4ujd A4 119 8.9 RF00001 URS00000F9D45_9986 25064512 0003735 0005840 9986 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcu .<<<<<<<<....<<<<<<<<.....<<.<<..............>>...>>....>>>>>>.>>.<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>.>>>>>>>>.. ((.((..(.....((((((((.....((......................))....)))))).)).((.(((.....((.((..((....)).)).))....))).))..)..)).).) mammalian 80S HCV-IRES initiation complex with eIF5B PRE-like state; 5S Ribosomal RNA 4ujd BA 76 8.9 RF00005 URS00005AA258_9986 25064512 0030533 0006412 9986 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... ((((..(..((((.....[..)))).(((((.......))))).....(((((..]....))))))..)))).... mammalian 80S HCV-IRES initiation complex with eIF5B PRE-like state; TRNA 4ujd BC 261 8.9 RF00061,RF00620 URS000080E1FF_11103 25064512 0043022 0006417 11103 ccugugaggaacuacugucuucacgcagaaagcgucuagccauggcguuaguaugagugucgugcagccuccaggacccccccucccgggagagccauaguggucugcggaaccggugaguacaccggaaugauuugggcgugcccccgcaagacugcuagccgaguaguguugggucgcgaaaggccuugugguacugccugauagggugcuugcgagugccccgggaggucucguagaccgugcaccaugagcacgaau .<<<.<<<<.....<<<<...<<<.<<....<<<<<.......>>>>>.....>>.>>>....>>>>>>>>>>>.......<<<<<<<<<<<.<<<<<<<<<<<<.<<<<..<<<<<<....>>>>>><<...>>.<<<....>>>>>>>..>>>>>>>><<<.....<<<......>>>....>>>....>>>>.>><<<<....>>>><<.((((((.>>>>>>>>>>>.))))))....................... ((((.((((.....(((.....((.((....(((((.......))))).....)).))......)))))))))))......(((((((((((..((((((.(((((((((..((((((....))))))(((.))).(((....))))))).))))).)))(((.....(((......)))....)))....)))..))((((....))))((.[[[[[[.))))))))))).]]]]]]....................... mammalian 80S HCV-IRES initiation complex with eIF5B PRE-like state; HCV-IRES 4ujd C1 1742 8.9 RF01960,RF01959,RF00177 URS00005A14E2_9986 25064512 0003735 0005840 9986 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucgcuccucucccacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucagaucaaaaccaacccguagauaaccucgggccgaucgcacgccccccguggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcgcgccccuugccucucggcgcgcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggucggcccacggcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<..{.[[[[.>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<...<<<.....................>>>>>......<<........<<<......<<....<<<......................<....<<.<<.......>>.>>......>...........<<<...<<<<<......>>>>>...>>>.....<<<<<........((((((.....>>>>>...........<<<<..<<<......>>>.>>>>....>>>...>>....>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<<<<<<....>>>>...>>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....<<<<<<<<<.<<<....>>>..>>>>>.>>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<[[.....<.<<...<<<.<<....<<<.<<<>>>>>>.......<<<<.<..>>>>>.....<<<<<..<.......<<...<.......>..<<<.......>>>....>>......>..>>..>>>..........<<.<<<<<<<.....))))))....>>>>>>>.>>......>>....<<<<<<......<<<<..<<..<<<<<<<....<<<......>>>.......>>>>>>>..>>.......<<....>>...>>>>.....>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<....<<<<<<.<<<<......>>>>>>>>>>....>>>...<<..]]>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..]]]].}<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<........<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<...<.<<....<<...<<<<....>>>>..>>....>>.>...>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.....>.>>>>>......>>>>.>>>.....<<.<<<................<<<.<<<<....>>>>.>>>..............>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<.<<<<<<<<<<<<.....>>>>>>>>>>>>...>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>.........<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..)))).((.(((.((...(.....((.....(((.(((..(....(((.....................))).)......(((.......(((...(..(.....(((......................(....((.(((.....))).))......)...........(((...((.(((....))).))...))).....(((((.......[[..[[[.....))))).............((.(.((......)).)))......)))....))...))).(((....(((....(((((((.........))))))))))......)))....((.((((....))))....)).))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.....))).))))).)......).....((.((((((.(((....)))..))))).).))......(...(...........)...).........((((([[......((((.....((..]])).......)))).)))))..)).))).))...{......(.({{.....(.((....((.(......((.((()))))........((((.(())))))........(((.(.......((..(.........).(((.......)))....))......).)))................(.(.((((......]]]...]]...)))).).)........)...(((.(((..(...((((..((..((((((.(...((........))......).))))))..)).......((....))...))))..)..)))..))..)))....)).)....((((((....(...((.(.........).))...).))))))......<...(((.((..((..(.((((((.((..........)))))))).)..))....((..}}))...))...}.))).).)..((......((((....))))....))....]]].](.(((.(..(((...((..(((((..(((.((((((.......(........)...........(((((.(....((((.........((..((........))..)).......))))...((.(((..((.((((((....(((.(((.(....).)....((......))....)).)))....(((...(.(.(((...((.(....(((...(((....)))..)))....).))...)))).).....((((.......))))........)))....))).))).....))))))).....).)))))...)).)))).))).(...((.(((........(.......(((.(.((....)).).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....((.((..(.......)..)).))......))....).)).))))..)..(.(..((.(..((((.((..(.((((.(((.(((..(.((..(...((.((.(((((.(((.((.....)).))).)))))...)).))...)..)).)..))).))).)))))..)).))))...).))...)..)..(((((((((....)))))))))>........ mammalian 80S HCV-IRES initiation complex with eIF5B PRE-like state; 18S Ribosomal RNA 4uje AV 76 6.9 RF00005 URS00005AA258_9986 24995983 0030533 0006412 9986 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).(((((.......))))).....(((((..]....)))))))))))).... Regulation of the mammalian elongation cycle by 40S subunit rolling: a eukaryotic-specific ribosome rearrangement; TRNA-LYS 4uje AW 76 6.9 RF00005 URS00005AA258_9913 24995983 0030533 0006412 9913 gcccggauagcucagucgguagagcaggggauugaanauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((........)))).(((((.......))))).....(((((.......)))))))))))).... Regulation of the mammalian elongation cycle by 40S subunit rolling: a eukaryotic-specific ribosome rearrangement; TRNA-PHE 4uje AX 28 6.9 24995983 562 uuuuuuuuuuuuuuuuuuuuuuuuuuuu ............................ ............................ Regulation of the mammalian elongation cycle by 40S subunit rolling: a eukaryotic-specific ribosome rearrangement; Messenger RNA 4uje B1 1742 6.9 RF01960,RF01959,RF00177 URS000080DD44_9986 24995983 0003735 0005840 9986 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucgcuccucucccacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucagaucaaaaccaacccguagauaaccucgggccgaucgcacgccccccguggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcgcgccccuugccucucggcgcgcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggucggcccacggccucggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<..{.[[[[.>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<...<<<.....................>>>>>......<<........<<<......<<....<<<......................<....<<.<<.......>>.>>......>...........<<<...<<<<<......>>>>>...>>>.....<<<<<........((((((.....>>>>>...........<<<<..<<<......>>>.>>>>....>>>...>>....>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<<<<<<....>>>>...>>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....<<<<<<<<<.<<<....>>>..>>>>>.>>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<[[.....<.<<...<<<.<<....<<<.<<<>>>>>>.......<<<<.<..>>>>>.....<<<<<..<.......<<...<.......>..<<<.......>>>....>>......>..>>..>>>..........<<.<<<<<<<.....))))))....>>>>>>>.>>......>>....<<<<<<......<<<<..<<..<<<<<<<....<<<......>>>.......>>>>>>>..>>.......<<....>>...>>>>.....>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<....<<<<<<.<<<<......>>>>>>>>>>....>>>...<<..]]>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..]]]].}<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<........<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<...<.<<....<<...<<<<....>>>>..>>....>>.>...>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.....>.>>>>>......>>>>.>>>.....<<.<<<................<<<.<<<<....>>>>.>>>..............>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<.<<<<<<<<<<<<.....>>>>>>>>>>>>...>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>.........<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..)))).((.(((.((...(.....((.....(((.(((..(....(((.....................))).)......(((.......(((...(..(.....(((......................(....((.(((.....))).))......)...........(((...((.(((....))).))...))).....(((((.......[[..[[[.....))))).............((.(.((......)).)))......)))....))...))).(((....(((....(((((((.........))))))))))......)))....((.((((....))))....)).))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.....))).))))).)......).....((.((((((.(((....)))..))))).).))......(...(...........)...).........((((([[......((((.....((..]])).......)))).)))))..)).))).))...{......(.({{.....(.((....((.(......((.((()))))........((((.(())))))........(((.(.......((..(.........).(((.......)))....))......).)))................(.(.((((......]]]...]]...)))).).)........)...(((.(((..(...((((..((..((((((.(...((........))......).))))))..)).......((....))...))))..)..)))..))..)))....)).)....((((((....(...((.(.........).))...).))))))......<...(((.((..((..(.((((((.((..........)))))))).)..))....((..}}))...))...}.))).).)..((......((((....))))....))....]]].](.(((.(..(((...((..(((((..(((.((((((.......(........)...........(((((.(....((((.........((..((........))..)).......))))...((.(((..((.((((((....(((.(((.(....).)....((......))....)).)))....(((...(.(.(((...((.(....(((...(((....)))..)))....).))...)))).).....((((.......))))........)))....))).))).....))))))).....).)))))...)).)))).))).(...((.(((........(.......(((.(.((....)).).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....((.((..(.......)..)).))......))....).)).))))..)..(.(..((.(..((((.((..(.((((.(((.(((..(.((..(...((.((.((((((.((.((.....)).)).))))))...)).))...)..)).)..))).))).)))))..)).))))...).))...)..)..(((((((((....)))))))))>........ Regulation of the mammalian elongation cycle by 40S subunit rolling: a eukaryotic-specific ribosome rearrangement; 18S Ribosomal RNA 4uje A2 3616 6.9 RF02543,RF02540 URS000043B91E_9986 24995983 0003735 0005840 9986 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggccggcgcgcgcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcggcccggcggaucuuucccgcgcgggggaccgucccccggaccggcgaccggccgccgccgggcgcauuuccaggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucgggggcccccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcgcucuccccccucccggccccccggggggggccgggccaccccucccacggcgcgaccgcucucccaccccuccucccgggucggggggcggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccgggggagguucucucggggccacgcgcgcgucccccgggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgaggggcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcuccaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcacugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggaggccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcugggugcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacaugagagguguagaauaagugggaggcccgggccgccggugaaauaccacuacucugaucguuuuuucacugacccggugaggcgggggggcgagcccgaggggcucucgcuucuggcgccaagcgcccgcccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucgccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcgaacgauacggcagcgccgcggagccucgguuggccucggauagccggucccccgccuguccccgccggcgccgcgcgccgggaccgggguccggugcggagugcccuucguccugggaaacggggcgcggccggaaaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuu .........................<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..[[[..<.......<..<<....<.....>....>>..>.......>..<<<<<<<<.......<<.<<<.<<<.......<<<<.....<<<<......>>>>.....((......<<<.....))>>>.....>>>>>>>>>>>>....>>>>>>>>.......<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>................<.......>....................................<<<<<<<<..<<<......<<<<<.<<<<.........<<<<<<<......<<<<..<<<<.<<<.<<<<.<<<<.<<<<<<<<>>>>>>>>..>>>>.>>>>.>>>.>>>>.>>>>>>>>>>>.......>>>>.>>>>>..<<<<<.<<..<<<<<<<.<..<<<.<.........<<.<<<.....<<.<<<<<<<..>>>>>>>...>>....>>>.>>...........>.>>>.....>>>>>>>>..............<<.<<<..<<<<.....<<....<<<<<<<<<..>>>>>>>>>...<.<<<<<.<<<<<<<<<<<<<<.<........<<<.<.<<..>>..>>>>...<<<<<<.<<<......>>>.>>>>>>.>.>.>>>>>>>>>>>.>>....>>>>>.>.........>>......<<<.<<<<<<<..>>>>>>>>>>.>>>>.>>>..>>...>>..>>>>>....>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<<....>>>>>>>>..<<<<<..<<<<..<<<...........>>>..>>>>..>>>>>.<<<<<<<<<.<<<........>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<......<<<....>>>..<<.<<<<<<.<<.<<<<<<<<....<<<....<<<....<<<..<<<<.<.........>.>>>>>>>....>>>..>.>>....>>>>>>....<<<<<<<<.........>>>>>>>>....>>>>..>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<......<..........<<<.<<<<<<<<<........<<...>>....>>>>>>>>>>>>..........))).>....>>>>>..>>>...>>>>>>><<<<<<.<...>.>>>>>>....>>>>>>...<<<<<<<..<<......<<<<.<<<<....>>>>>>>>....>>.>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<<<<<...>>>>>>>>>>>......>>....>>...<<<<<........>>>>>))<<<<..<<.......<<<<<<<<....>>>>>>>>..<<<....>>>......<<<<<<<...<<<<<<<<<<<<<<<<<<<<<<<..{{{..>>>>>>.....<<<<..<<<.<<<<.....<<<.....>>>.....>>>>>>>...>>>>......<<<<<<<.......>>>>>>>>>>>.>.>>>>>>>>>>>>.........>>>>>>>................>>..>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<...............<<<<<...............>>>>><<.<<<<<<<<<<......>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>>.<<<<.........>>>>.........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{.[[[[..<<<<<.<<<<<<<<<.<<<<<<<<<<.<.<<<<..........<<<<<..<<<<..>>>>............>>>>>.>>>>.>..>>>>>>>>>>...<<<<<......<<<.....<<<.<.....>.>>>................<<<<<<<......>>>>>>>..>>>...>>>>>....>>>>>>>>>..>>>>>....<<.....>>...<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>>.<<<....>>>.>>)))]......((((((..(((..>>>>>>.)))))))))..........]]]]...}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]].....<<<<<<....<<<....<<<<<.................>>>>>..<<<<....<<<<....<<.<<<<<<.}}}..>>>>..>>.>>...>>>>...>>>>.<<<<...<<<<<...........>>>>>...>>>>..>>>....>>>>>>.....<<<<<<<.<<..<<<.<...<<<.........<<<<.<<<....<<.....<<<<<<..>>>.>>>..>>.....>>>.>>>>........>>>...<<<..<<<.....<<<<.<<<<<<<......>>>>>>>>>>>....>>>..>>>.............>.>>>..>>>>>>>>>.<<<<.....................<.<<<<<<<.<<.....<<<<....<<<<<......>>>>>...>>>>....>>....>>>>.>>>.>..>>.>>. .........................(((((......(......).......)))).).........((....))...((((......((.....)).....))))...(((.............((...............)).............((((((((..........(((.((........((((.....(((........))).....[.(...).(((......]))).....)))).)))))......)))))))).......((((((..........))))))......(.((..[[[..[)).)...)))..................................((....))............(..((.(....).))............).....................(((((((...(((.......((((.(((........(.(((((((......(((((.((((.((..((((.(((..(..((((()))))..)...))).))))..)).)))))))))))))))).)......))).))))....((((((..(.((.(((.(.(((..((......(.((.((((....(..(((((((())))))))....)...)))).)).)........))..)))...).))).)).)..............(((((..(.(.....(((..((.((((((((..)))))))).)).(.(.((((..(.((((((((((.((......(((.(..((()))..).)))..((.(((.((........)).))).)))).).))))))))).)...)...))).).).........)))......((.(((((((())))))))))...).).))).)).....).))))).....)))....)))))))..((((........))))((((((....(((((((((((((..(((...((((........)))).....)))...((....))...((((((((....))))))))...((((...(((..(((...........)))..)))...))))..((((..(((.((((......)))))))..)).))....)))))))))))))..((.(...((((((.....(((((((((..((.....(((((((....)))))))......))...(((..((.((.......{)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((.(..((.(((((((.....(((.....((..(.(((...(.....(.....).....).))).)..))...)).).....))))).....(((((((.(......)))))))).....))))...).)))..))..((((.(((((.....))))).))))....(((......)))...((((.((...((([[[.....(.(((((......(..........(((.((((((((((........(...)....)))))))))))))..........]]].)....)))))).)))...)).))))(((((.........)))))....)))))).(.(((((((..((.......(((.((((....))))))).....)).)))))))..).....)))))).(......(.....((((((.......)))))).(((.....((((..((..(((((((...((.....)).))))))....[[(((.((...(.....(((....)))..........((.(((..(.((...)).)..))))).......)....))...(((((........)))))]]((((..((..(....(((.(((......))).))).((((....)))...(...(((((....(((.(((.((((((((((.(((.........))).)......(...((((.((((.....(((.....))).....))))))))....).......(((((((.......))))))))))).).)))).))).)))(...).....)))))...))..........).))..)))).))).))).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((....)))))..)))))).))(...).......(((((((((...((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(...((.....((((....)))).....)).)))))..))))).((.(.........).).)........((..........((((.........))))..)..)....)))....)).))))))).)..))).)))))))..))))).....)..[..(((((......].)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((.(.((((.(((...........(((((..((((()))))............)))))..))).)).)).).)))))....((((.......((.....((((((...))))))................(((((((......)))))))...))...))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((...((((((.......)))))).....((]..[[[))....)))))))...(((..((((.......))))..))).((......)).))]]].......((((((..(((..]..]]].)))))))))....).....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).).......(((((.(..(((..(...(.(((......))).).....).(((.(.....).))).....)))....)...))).))....(((((((....))).))))..}.))..))).)))))......(.(((....(((....(((((......(....).....)))))..((((....((((....(..(.(((((....)))))...)..)...))))...)))).((((...((((.............))))...))))..)))....))).)......((((((..((..((.(....(((.........((((.((((..((.(....((((((()))).))).).))...)))).))))........)))....((...(((....((((.(((((((......)))))))))))...)))...))...............).))..)).)))))).((((....(.......)........(.(((((((..(.....((((.(..(.((........)).)..)))))....).....)))).))).)..)).)). Regulation of the mammalian elongation cycle by 40S subunit rolling: a eukaryotic-specific ribosome rearrangement; 28S Ribosomal RNA 4uje A3 157 6.9 RF00002 URS000080DE76_9986 24995983 0003735 0005840 9986 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>.............>>>..)...>>>....<<<..>>><<<<<<<<<.....>>>>>>>>>..................... .........................................((((((.[[....[)))...].(.((((.....]]...........).)))..)...)))....(((..))).((((((((.....))))))))...................... Regulation of the mammalian elongation cycle by 40S subunit rolling: a eukaryotic-specific ribosome rearrangement; 5.8S Ribosomal RNA 4uje A4 119 6.9 RF00001 URS00000F9D45_9986 24995983 0003735 0005840 9986 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcu .<<<<<<<<....<<<<<<<<.....<<.<<..............>>...>>....>>>>>>.>>.<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>.>>>>>>>>.. ((.((..(.....((((((((.....((......................))....)))))).)).((.(((.....((.((..((....)).)).))....))).))..)..)).).) Regulation of the mammalian elongation cycle by 40S subunit rolling: a eukaryotic-specific ribosome rearrangement; 5S Ribosomal RNA 4uy8 A 2854 3.8 RF02540,RF02541 URS000080DD2C_562 25310980 0003735 0005840 562 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((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((((((.)))).))...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..((((......))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((((.(.............................................).))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Molecular basis for the ribosome functioning as a L-tryptophan sensor - Cryo-EM structure of a TnaC stalled E.coli ribosome; RRNA-23S RIBOSOMAL RNA 4uy8 B 118 3.8 RF00001 URS0000366A67_562 25310980 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))). Molecular basis for the ribosome functioning as a L-tryptophan sensor - Cryo-EM structure of a TnaC stalled E.coli ribosome; RRNA-5S RIBOSOMAL RNA 4uy8 V 77 3.8 RF00005 URS000034D020_562 25310980 0030533 0006412 562 cggcacguagcgcagccugguagcgcaccgucauggggugucgggggucggaggnucaaauccucucgugccgacca <<<<<<<..<<<<.........>>>>.<<<.<<.....>>.>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((......[..)))).(((.(.......).))).....(((((..]....)))))))))))).... Molecular basis for the ribosome functioning as a L-tryptophan sensor - Cryo-EM structure of a TnaC stalled E.coli ribosome; RNA 4v19 A 1515 3.4 RF02541,RF02540 URS000080E15B_9823 25271403 0003735 0005840 9823 accaaagcuagcucaacaacaaauacaaaaauacaccaaaauaaaauaaaacauucaccuaacauuaaaguauaggagauagaaauuuuuauccugacgcuauagagauaguaccguaagggaaagaugaaagaauaaaaguaaaaaaaagcaaagauuaccccuucuaccuuuugcauaaugguuuaaccagaaaaaaucuaacaaagagaacuuuagcuagauaccccgaaaccagacgagcuacccaugagcaguuuaaaagaaccaacucaucuauguggcaaaauagugagaagacuuguagguagaggugaaaagccuaacgagccuggugauagcugguuguccgagaaagaauuuuaguucaaccuuaaaaauaccccaaaaacccuaaauuccaauguauuuuuaagagauagucuaaaaagguacagcuuuuuagaaacggauacaaccuugacuagagaguaaaucuuaauacuaccauaguaggccuaaaagcagccaucaauugagaaagcguuaaagcucaacaaauucaccaacauaaucccaaaaacuaauaacaaacuccuagcccaauaccggacuaaucuauugaaacauagaagcaauaauguuaauaugaguaacaagaagccuuucuccucgcacacgcuuacaucaguaacuaauaauauacugauaauuaacaaccaauaaaccaaaacaacacuaaaacguuuauuaauuacauuguuaacccaacacaggagugcaccaaggaaagauuaaaagaaguaaaaggaacucggcaaacacaaaccccgccuguuuaccaaaaacaucaccucuagcauuacuaguauuagaggcaaugccugcccagugacaaguuuaacggccgcgguacugaccgugcaaagguagcauaaucacuuguucuccaaauaaggacuuguaugaauggccacacgaggguuuuacugucucuuacuuccaaucagugaaauuaaccuucccgugaagaggcgggaauaaaaaaauaagacgagaagacccuauggagcuuuaauuaacuauuccaaaaguucuuaacauggacuagcaauuucgguuggggugaccucggaguacaaaaaacccuccgagugauuuuaaucuagacaaaccagucaaaauaaucacuuauugauccaaaauuuugaucaacggaacaaguuacccuagggauaacagcgcaauccuguucuagaguuccuaucgacaauaggguuuacgaccucgauguuggaucaggacacccaaauggugcagccgcuauuaaagguucguuuguucaacgauuaaaguccuacgugaucugaguucagaccggagcaauccaggucgguuucuaucuauuauaaauuucucccaguacgaaaggacaagagaaaugggaccaaccucacaaacgcgucucagagauaauuaaugauuuaaucuuaaccuaauuaacucauaauaaauccagcccuagaacagggcaca <<.......<<<<<.................................<......>...........<.....<<.....>>....>.........>>.>>>............<<....>>...................>>...........<<<.......>>>...<.<........>.>..<<<<<........<<<<<.<..<<....>>...>.>>>>>..<<.<...<<<<.<.....<<<.<<<<<..<<<......>>>...<<<..<<<<........>>>>.>>>....>>>>>.>>>...<<<.....>>>......>.>>>>......>.>>..<<<<<.....<<<<....>>>>...<<<<<<<<<<<.....<<........>>.....>>>>>>>>>>>......<<<<<<<<<......>>>>>>>>>...<<......>>....<<<<.<<<..................<....<<<.........>>>....>.......<<<......>>>........................................>>>>>>>........>>>>>...<<<<<......>>>>>.........>>>>>.<......<<..<<<<..>>>><<<..<<<<........<<<<<....<<....>>..>>>>>......<<<..<<<<<<<.................>>>>>>>.......>>>.....<<......>>.>>>>.....>>>..<<<<....<<<<<<<.<<...............<<<<<<<<..<<<.........>>>...<<<<<<.............>>>>>>...<<<<.<<<..<<<<<..>>>..>>>>><<<<<<....>>>>>>........<...........<<<<<.......>>>>>.....>....>>>.>..>>.>>>>>>......>>.>>>>>>>.>>>>.>>.....>.....<<<<<........>>>>>.......<<<.<<<.<<......<<<<.<<<<<<..<<<<..<<<.<<<<.<<<..>>>....>>>>.>>>.>>>>..<<<<.....>>>><<<<<<...........>>>>>>.<<<<....<<...<<<......>>>...>>.>>>>..........<<<<..>>>>............>>>>..>>>>>>.......<<<..<.<<<<<<...<<.......>>...>>>>>>...>.>>.>.......<.<<<.<<<<<<..<<.<<<<<<......>>>>>>...>>.<<<<<.....>>>>>.....>>>>>..>...>>>..>....<<<<<<<....>>>.>>>>....>>..>>>>>>.<<.<<<<<<<.................>>>>>>><<<<<...............>>>>>.<<<.<.<<<<.................>>>>..>>>>.>>.........<<<<.......>>>>... ((.(...(..((((.................................(...[..)........(..(.....((.]...))....)..)......)).)).............((....))....).........)....))...........(((.......))).[.(.(........).)..(((((..(.....(((((.(..((....))...).)))))..((.(...((((.(.....(((.((((((.(((.....[)))...(((..((((.......{)))).)))..).))))).))).(.(((.....)))...)..).))))......).))).(((((.....((((....))))...(((((((((((.....((........)).....)))))))))))......(((((((((......)))))))))...((......))....((((.(((..................(.(..(((.........)))..).)....(..(((......)))).......................................)))))))........)))))...(((((......))))).........))))).(......((..((((..))))(((..((((......(.(((((....((....))..)))))......(((..(((((((...........(..)..))))))).......))).)...((......)).)))).....)))..((((....(((((((.((..(....(.......((((((((.].((.........))....((((((.............))))))....(((.(((..(((((..)))..)))))(((((......)))))........((..........(((((.......)))))..)..)....)))....)).))))))..)..))).))))))).)))).)).....)..{..(((((.....]}.))))).......(((.(((.((......((((.((((((..((((..(((.((((.(((..)))....)))).))).))))..(((......[)))((((((..........]))))))((((((..)((.(.(((...[..))))..)).))))..........(((....))).....)].....))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......((((.((((((..((.((((((......))))))...)).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..}.))..)))))).((.(((((((......(....).....)))))))(((((...(.(.....).).))))).(((....(((.................)))....))).)).........((((.......))))... Structure of the large subunit of the mammalian mitoribosome, part 1 of 2; MITORIBOSOMAL 16S RRNA 4v3p S3 11 34.0 URS000080E0BA_4565 25376914 4565 aaaagacuuca ........... ........... The molecular structure of the left-handed supra-molecular helix of eukaryotic polyribosomes; 40S WHEAT GERM RIBOSOME protein 4 4v3p S2 75 34.0 RF00005 URS00005AD0B9_4565 25376914 0030533 0006412 4565 uccgugauaguuuaauggucagaaugggcgcuugucgcgugccagaucgggguucaauuccccgucgcggagcca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>....<<<<<.......>>>>>>>>>>>>.... (((((((..((((........)))).(((.(.......).)))....(((((.......)))))))))))).... The molecular structure of the left-handed supra-molecular helix of eukaryotic polyribosomes; 40S ribosomal RNA 4v3p S1 1743 34.0 RF01960,RF01959,RF00177 URS0000B21DD3_4565 25376914 0003735 0005840 4565 uaccugguugauccugccaguagucauaugcuugucucaaaguuaagccaugcaugugcaaguaugaaccaauuugaacugugaaacugcgaauggcucauuaaaucaguuauaguuuguuugauggacucggauaaccguaguaauucuagagcuaauacgugcaacaaaccccgacuucugggaggggcgcauuuauuagauaaaaggcugacgcgggcucugcucgcugauccgaugauucaugauaacucgacggaucgcacggccuucgugccggcgacgcaucauucaaauuucugcccuaucaacuuuaugguaggauaggggccuaccaugguggugacgggugacggagaauuaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccugacacggggagguagugacaauaaauaacaauaccgggcgcauuagugucugguaauuggaaugaguacaaucuaaaucccuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuuaaguuguugcaguuaaaaagcucguaguuggaccuugggccgggucggccgguccgccucacggcgagcaccgaccuacucgaccccggcaucgcgcuccuagccuuaauuggccgggucguguuuccgguuagagugcucaaagcaagccaucgcucuggauacauuagauuccgguccuauuguguuggccuucgggaucggaguaaugggacagucgggggcauucguauuucauagucagaggugaaauucuuggauuuaugaaagacgaacaacugcgaaagcauuugccaaggauguuuucauuaaucaagaacgaaaguugggggcucgaagacgaucagauaccguccuagucucaaccauaaacgaugccgaccagggaucggcggauguugcuuauaggacuccgccggcaccuuagagaaaucaaagucuuuggguuccggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggcguggagccugcgcuuaauuugacucaacacggggaaacuuaccagguccagacauagcaaggauugacagacugagagcucuuucuugauucuaugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccguuaacgaacgagaccucagccugcuaacuagcuaugcggagccaucccuccgcagcuagcuucuuagagggacuauggccguuuaggccacggaaguugaggcaauaacaggucugucaugcccuuaauguucugggcgcacgcgcgcuacacugauguauucaacgaguauauagccuuggccgacaggcccggguaaucuugggaaauuucaucgugauggggauagaucauugcaauuguuggucuucaacgaggaaugccuaguaagcgcgagucaucagcucgcguugacuacgucccugcccuuuguacacaccgcccgucgcuccuaccgauugaaugguccggugaaguguucggaucgcggcgacgggggcgguucgccgcccccgacgucgcgagaaguccauugaaccuuaucauuuagaggaagcagaagucguaacaagguuuccguaggugaaccugcggaaggaucauug ...<<<<<.{.[[[[>>>>>.<<<..<<<<<...<...........<<<.<<<...<...<<.....<<.<.......(>>>....>>>.......<<........<<<..<<..........<<<....<<)....<..<<<.....>>>..>......>>.........<<<<..<<...>>..>>>>.....<<<<<<.....((((((((.<<<<<<...>>>>>>...............>>>>>>.....<...<<<<.<<.<......>.>>>>>>.>>>>.......>>..>>>.<<<....<<<...<<<<<<.........>>>>>>.>>>......>>>...<<<<<<<<....>>>>...>>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<...<<<<<...>>>>.>>>>.........>.....<<<<<<<<<<<<<....>>>>>>>>>>.>>>.......<.................>..........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>.>>>..........<.<[[.....<.<<...<<<.........<..<<...................................>>.....><<<.<.<<<<..<<<.<<<......>>>.>>>.>>>>.>.>>>.<<<<.<<<.<<<.<<<.<....>.>>>.>>>.>>>.>>>>.<<<<<<<<<<......)))))))).>>>>>>>>>>....<<<<<<.<<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>.>.>>......<<<....>>>..>>>>..>>.>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>..<<..]]>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..]]]].}<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<......<<........>>..........<<<<<........<....<<....<<............>>........>>....>......<<<..<<.<<<<<.....<<<.<<<<<....>>>...<<<......>>>...>>.>>>......<<<...<.<<<<..<<<<<<<<<<<<......>>>>>>>..>>>>>..>>>>.>........<<.......>>.........>>>.......>>.>>>.....>>>>>........>>>>>..>..>>>>.>>>.....<<<<.<<..................<<<<......>>>.>..............>.>.>>>>.........<.<<<<<<..........>>>>>>>.........>>>>>>....<<<<<<<<<.....>>>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<..<.<<...<<<<<<<<..<<<..<<<<......<<<<<<<<.<<<<<<<<<....>>>>>>>>>.>>>>>>>>......>>>>..>>>..>>>>>>>>..>>.>..>>..>.>>.........<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..)))).(((..(((((.....(...((....(((.(((..((...((.....((...........))....))))......(((.......(((..((..(........((..(.((........(((.....))).........)).).......((((..((...))..)))).....((((((.....[[[[[[[[.(...((...))...)...............))))))..........(((.((..........)))))...)).......)))..))).(((....(((...(((((((.......))))))).)))......)))...((((((((....))))...))))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...(((.(...).)).))))).)....).......(((((((.(((.(....).))).)))).)))....................................((((([[......((((.....((..]])).......)))).)))))..))))).)))..........(.({{...(.(.((...(((.........(..((...(..........(.......)........)...)).....)(((.(.(.((..(((.(((......))).))).)).).).))).((((.((...((.(((.(....).))).))...)).)))).(((((((((.......]]]]]]]]..)))))))))....((((((..(...((((..((..(((((((....((........)).......)))))))..)).......((....))...))))..)..))).)))...)))...)).)....((((.(....(...((((.........))))...).).))))......<...(((.((..((..((((((.(.(((........)))).))))))..))...((..}}))...)).....))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((.(..(((.(((((.......(........)...........(((((...................(............).....................(.(((...(.((((((....(((.(((((....)))....((......))....)).))).....((((...(.((((..((((((((((((......)))))))..)))))..))))).........(((.....))).........))).)....))).))).....).)))).......)))))..)..)))).))).(...((.....................(..((((....))))..)...................))......(....(((.((..........)).)))....)..)..).))).....((((((((.......))))))))......))...)))))))))).)).......((.(.((.((.((...((((((((..(((..((((..(...(((((.((.(((((((((....))))))))).)).)))))...)..))))..)))..))))))))..)).)).))..).))..........((.(((((....))))).)).>........ The molecular structure of the left-handed supra-molecular helix of eukaryotic polyribosomes; 18S ribosomal RNA 4v3p L1 3352 34.0 RF02540,RF02543 URS0000B21DE9_4565 25376914 0003735 0005840 4565 gcgcgaccccaggucaggcgggacuaccgcugaguuuaagcauauaaauaagcggaggagaagaaacuuacaaggauuccccuaguaacggcgagcgaaccgggagcagcccaagaaucgggcggcugugccguccgaauuguagucuggagaggcguccucagcgacggaccgggcccaaguccccuggaaaggggcgccugggagggugagagccccguccggcccggacccugucgccccacgaggcgccgucaacgagucggguuguuugggaaugcagcccaaaucgggcgguagacuccguccaaggcuaaauacaggcgagagaccgauagcgaacaaguaccgcgagggaaagaugaaaaggacuuugaaaagagagucaaagagugcuugaaauugccgggagggaagcggaugggggccggcgaugcgccccggccguaugcggaacggcucuugcugguccgccgcucggcucggggcguggacuguugucggccgcgccggcggccaaagcccgggggcuccgcgcccccggcagccgucgucggcacggccgguacccgcgcgccgaaaggcgugccccucggggcacugcgcugcaacgcccugcgggcuccccauccgacccgucuugaaacacggaccaaggagucugacaugcgugcgagucgacggguucugaaaccugggaugcgcaaggaagcugacgagcgggaggcccucacgggccgcaccgcuggccgacccugaucuucugugaaggguucgaguuggagcacgccugucgggacccgaaagauggugaacuaugccugagcggggcgaagccagaggaaacucugguggaggcucgaagcgauacugacgugcaaaucguucgucugacuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggagcccauuacgaguucuaucagguaaagccaaugauuagaggcauuggggacgcaacguccucgaccuauucucaaacuuuaaauagguaggauggcgcggcugcuucggugagccgugccauggaaucgggugcuccaagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccggaagccggguuacggugcccaacugcgcgcuaaccuagaacccacaaaggguguuggucgauuaagacagcaggacgguggucauggaagucgaaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagccccgaaaauggauggcgcugaagcgcgcgacccacacccggccaucugggcgagugccaugccccgaugaguaggagggcgcggcggccaugcaaaacccgggcgcgagcccgggcggagcggccgucggugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaaggccgaagaggagaaagguuccaugugaacggcacuugcacauggguaagccgauccuaagggaagggguaaccccggcagauagcgcgaucacgcgcauccccgaaagggaaucggguuaagauucccgagccggguguggcgguugacggcgacguuaggaaguccggagacgccggcgggggccucgggaagaguuaucuuuucugcuuaacggccugccaacccuggaaacgguucagccggagguagguccaguggccggaagagcacacgucgcgcgguguccggugcgcccccggcggcccaugaaaauccggaggaccgaguaccgucacgcccggucguacucauaaccgcaucaggucuccaaggugaacagccucuggccaauggaacaauguaggcaagggaagucggcaaaacggauccguaacuucgggaaaaggauuggcucugaggacugggcucgggggucccggccccgaacccgucggcugucggcggauugcucgagcugcucacgcggcgagagcgggucgccgcgugccggccgggggacggaccgggaaucgccccuucgggggcuuuccccgagcaugaaacagucgacucagaacugguacggacaaggggaauccgacuguuuaauuaaaacaaagcauugcgaugguccucgcggaugcugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaaugaauuaacgagauucccacugucccugucuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuaguccgacuuugugaaaugacuugagagguguaggauaagugggagcccucacgggcgcaagugaaauaccacuacuuuuaacguuauuuuacuuauuccgugggucggaagcggggcaugccccaaggcccggucuuaccgggccgauccgggcggaagacauugucagguggggaguuuggcuggggcggccaaucuguuaaaagauaacgcagguguccuaagaugagcucaacgagaacagaaaucucguguggaacaaaaggguaaaagcucguuugauucugauuuccaguacgaauacgaaccgugaaagcguggccuaucgauccuuuagacuucggaguuugaagcuagaggugucagaaaaguuaccacagggauuacuggcuuguggcagccaagcguucauagcgacguugcuuuuugauccuucgaugucggcucuuccuaucauugcgaagcagaauucaccaaguguuggauuguucacccaccaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugacagugucgcgauaguaauucaaccuaguacgagaggaaccguugauucacacaauuggucaucgcgcugguugaaaagccaguggcgcgaagcuaccgugugccggauuaugacugaacgccucuaagucagaauccaagcuagcaugcgacgccugcgcccgccgcccgccccgacccacguuaggggcgcuugcgcccccaagggcccgugccauuggcuaagccgguccggccgaagugccgcggucggccgccucgaagcucccuucccaacgggcggugggcuaauccuuugcagacgacuuaaauacgcgacggggauuguaaguggcagaguggccuugcugccacgauccacugagaucccgcgucgcacggauucgu 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..........................(((((.....(...[..)......))).).)...(.....((....))...((((.......(.]...)......))))...((((.....((((.((((...)))).)))).............((((((.((((.(((((.(.(((((((...({((((......)))))[[......(((....}]])))....)))))))...).))))).....)))))))).))...)....(((.((..........)).))).....((.((..[.....)).))..)))....).............................((....))............(..((........))............).......................((((((((((.((...((((((((((((..((((((.(.((....)).).)))).))..)))).))))))))....((((((((((((.(((((((((......((((((((.....)))))))).....))))))))).))))))).....(((((((....)))((((((....)))))).))))..)))))....)).))).))))))).....(((........))).((((((....(.((((.((((((..((...((((((....))))))....))...((....))..(.((((((.(((((....))))).).))))).).(((((((...(....)...)))).))).......)))))).)))).)..((.(...((((((.....(((((((((..(.((....((((((....))))))....)[).)....((..((.((........)))).)).....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)(.((((((......(((...(((((...(((((....(((..(.(((..(.(((((.......))))).)))).)..)))..)))))....)))))...(((((((((((....)).)))))))))......))..).))))))..)..((((.((.((.....)).)).))))....(((...{..)))...(((((((...((([[[...(.((((((..........}.......(((.((((((.(((.......(((((.(((...((.........))...))).....(...((......)).).)))))...))).)))))))))..........]]]......))))))))))...)))))))((((.((((.........)))).))))....))))))(.((.(((((........(((((((....)))))))......))))).))..).....))))))((.....((.....((((((.......))))))(((((....((((..((..(((((((...(.......).))))))....[[(((.((...(((...(((....)))........(((((....)))))...)))....))...(((((........)))))]]((((((((.((((.((((....)))...(...((((((...((((.((.((.(.(((((.((((...{...)))).).(..(.(.(.(......(......(((.....))).......).....).).).)...).(((.((.....))))).)))).)...).))).))))(...)....))))))...))....)))).)))))))).))).))).....((......)).))))..((.......)))..))))..((((.....((((.((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((.((((((((.((((((..(((..((((.((((.(.(((((....((((..((.((....)).))..))))....))))))..)))).)..)))..))).))))))...(((((....)))))...))))))))......)))))..)))))).))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..((((.(.(..(((.....((((....)))).....))))).))..)))))(((((.........)))))........((.(......).((((.........))))..)..)....)))....)).))))))).)..))).)).))))..))))))....)).[..(((((.......])))))....(((((..(((.((......((((.((((((..(((((.(.(.(((...(((((((((((((((((...{...[..((((...((((....)))).......}..]..)))).))))))).))))))))))...(((((.....((((...((((....))))..((((((((...))))))))..))))..)))))......))).).)..)))))...((......[))..((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((.......))))..))).((......)).))]]].].....(((((..((((.....].)))).)))))....).....))))..)))))).......(..(.(..(((((...((.......))...)))))....))...).......(((((.((((((..(((.(.(((......))).)...))).(((.........))).....)))))..)...))).)).....((((((....))).))).....))..))).)))))....((((((...(((..(.(((((......(....).....))))).)(((((...((((...((((((((.(..}.).)))...)))))..))))..)))))..((....((((.............))))....))...))).....))))))....((((((((((((.......((......((((((....))))))...))..(((......)))....(((((((((((......)))).)))))))......................)))))))))))).((((.(..(.......)..).....((((((((.(((....((((....(((((......)))))...))))...))).)).))))))...))))... The molecular structure of the left-handed supra-molecular helix of eukaryotic polyribosomes; 26S ribosomal RNA 4v3p L3 120 34.0 RF00001 URS0000188192_4565 25376914 0003735 0005840 4565 ggaugcgaucauaccagcacuaaggcaucggaucccgucagaacuccgaaguuaagcgugcuugggcgagaguaguacaaggaugggugaccucuugggaaguccucguguugcauuccc <<.<<<<<.....<<<<<<.......<<<<<..............>>>..>>......>>>>.>>.<<<<.<.......<<<<.<<....>>>>>>......>.>>>>..>>>>>.>>.. (((((((((....(((((((......((((((...(....)...))))..)).....))))).)).((((.((....(.((((.((....)))))).)...)).)))).))))))))).. The molecular structure of the left-handed supra-molecular helix of eukaryotic polyribosomes; 5S ribosomal RNA 4v3p L2 159 34.0 RF00002 URS000081169E_4565 25376914 0003735 0005840 4565 gacucucggcaacggauaucucggcucucgcaucgaugaagaacguagcgaaaugcgauaccuggugugaauugcagaaucccgugaaccaucgagucuuugaacgcaaguugcgcccgaggccacucgggcgagggcacgccugccugggcgucacgc ........................................<<<<<<........>>>....<<.......<<<....>>>..............>>..>>>....<<<...>>><<<<..<.<<....>>.>..>>>>..................... ........................................((((((.[......)))....((.......(((.]..)))..............))..)))....(((...)))((((..(.((....)).)..))))..................... The molecular structure of the left-handed supra-molecular helix of eukaryotic polyribosomes; 5.8S ribosomal RNA 4v42 AB 76 5.5 RF00005 URS000011107D_274 11283358 0030533 0006412 274 gcggauuuancucagnngggagagcnccaganunaagaunuggagnucnugugnucgnuccacagaauucgcacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of the ribosome at 5.5 A resolution.; TRNA(PHE) 4v42 AC 76 5.5 RF00005 URS000011107D_274 11283358 0030533 0006412 274 gcggauuuancucagnngggagagcnccaganunaagaunuggagnucnugugnucgnuccacagaauucgcacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... .((((((..((((.....[..)))).((((.........)))).....(((((..]....)))))))))))..... Crystal structure of the ribosome at 5.5 A resolution.; TRNA(PHE) 4v42 BA 2889 5.5 RF02540,RF02541,RF00002 URS000080E1D6_274 11283358 0003735 0005840 274 ggucaagaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaugcggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgaggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucuugacc <...<<<<.......<<<<<<<<<<...[<<<..<<<<<<<.<<....<..[<<<<<<.{...((]>>>.....<<<<<<....<<))}....>>.......>>>>>>...>>>....<<.....>.><<<<<<<<.{..>>>>>>>>.<<<<<......>>>>>......(<<<<<<..[.<.....[>>.....>>>>>.>)....{...<.....>....<<<<<..........].].....>>>>>...<<<<..<<<<<<<<<.....>>>>>>>>......<<<.<<<..........<.<<<(..<<<(.<<.....<<<<......>>>>.........<<<.......>>>..).>>....>>>..>).>>>......>>>..>>>...>.<<<<<...<.......>}..>>>>>......<<<(......>.)>>..>>>>......>>{.>>>>>.>>....<...]>.....<<.<..>>....>>>........<<<.....>>>...................>>>>>>>>>>.........<<<<<<<<<<.<..>>>>>>>>>>....<..............><<<<<<...<<<<<<<<<<<<...<<<...<<<.....>>>..>>.>.............<<<<.....>>>>......>>>>>>>>>>>>..<<.<...<<<<<.....<<<<<<<<<<..<<.<...<<<<<<......>>>>>>....>.>>...<<<<(<<...........>.>>>>>....>>>>>>>>>><.<<....)..>>...>...>>>>>.}....>.>>...<<<<<....<<<<<....>>>>>.<{<<<<<<.....<<<<<<<<<...<<......<.<.......<<<<<......>>>..>>....((>.>.....>>....>>>>>>>>>.....>>>>>>>.....<<<<<<<.<......<<>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((...{.<<<<<<.....)..<..<<.<<<<<<<<<<......<.<<<<<.<<...<<<<.....(.>>>>...>>.....<...<<......>>>).>>>>>.>..>>>>>>>>>>>>........[[.))..}.>..>>>>>>.>>>...>>>>>>>.<(.<<<......>>>.>)}.....>>>>>....(([....(........<<<<>........>>...>>.....)...)])........>>>>>><<...<..<<.....<<<<<<..(...(>>>>>><<<.....<<<[<.<<....<<<<<<..<<)....>>>>>>>>......(<<<..<<<..<<<...<<<....>>>...>>>..>>>[...<<<<........>>>>{).<<<<<<<<<<.<<...<<<<([..<<<<<....<.<<<<<...<<.<...........>>>..<<....<<..<<<..<<<<<.<.<.....).>>]>>>>>......>]>>>>.....>>}...<<<..)..]>>>......>>>>>>.......>>>>>.........>>>.>..>>....>>>>>>>>>>}>>>..>>......<...>..>.>.>>>..<<<......>>>....>>>..<<<<....<<<<<<<..<<.......(....<...<<<<.....<....(.>..>>>><<<<<<<<<<<........>>>.>>>>>>>.>{.>.......<<<<<<<<<.)<......{......>.(<<[<<.<....<<<<....>>>....>.)>]>>.>>.<<<<<<.....<<<<.<<..<<<...<<[..<<<.......>>>....>>...>>>>>>.>..>>...(<<<..........)>>>.........<<..........<<<<<<)....>>>>>>..>>..>...>>>>>..>>.>>>>>>>.....>>..>>>>>>>.>>>>>>....>>>.(..<<<<<....{.).>>>>>..<<<<<<<<.<<<.<<......<<<<..{.<<<..<<<<..<<<.<<<<<.<<<<.<.<<<<<<(.<...........<<(.<..<<.<....><<<<<<<<....>>>>>>>>....>>.....>......>>)....>>).>>>>>>..>>>>...<(.<......>>)...].>>>>>.>>>...>>>>.....>.>..<....<<.<<<...........>>>.>>..<<...[.<<<<....<<<<<<.......>>>>>>))....<.....>.......>>>>.....<<<<..<<<......>>>..>>>>.<<<....>>>.>>..].<<.......<<<<<<.........>>>>>>.......>>.......>>>}....>>>>.....}.<<<<..<<<<<<<<..<<..(....>>>).>>>>>>>...>>>..>........<<<....<<]].<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>......>>>>.......>..}.....<<<<<<<>...>>>.>>>>....>>..>>>>>>>>>>>....<<<<<<<...<<<<...<<<<<<...........>...>>.>>>..<<<<<...<<<<...<<<<<<<<<<.....>>.>>>...>>>>>...>>>>.>>>>>...<<<.<..<<<<........<...>>>>>...>>>>.>>>>.......>>>>>>><.<<<<.....>>>>....<<.<.<<<<.......>>>>>....<<<<<<<<<<......<<<<......>>>>...}>>..>>>>>.>>>.....>>>...>>>>..>. (...(((..........((.(((((.....(..((...((((..........((........[[..........((((((.......]].............))))))....))....(........)(.(((.(......).))).)..(((........)))........(((((...................)))))......................((((....................))))...(......(((.(((.......))).))).......((..(..............((((..((.........(((.(.....)))).........((.........))..........))...))))..........)...)).....((((.................))))..........(.....).........).........))))....))..............(......).....).......................................))))).))............(((..((........))..))).....................((((.....(((((.((.((...........(.......)......................(.......).........)).)).)))))..((.....(((((......((((.......((.(....((((........)))).....).))...((...(((..........)))..)).........))))...((.......)).......)))))........)).....((.....((((......))))..(.(((((..(...((((.((........................((........))........[................)).))))....).))))).)......((((((............)))).)).....((........))...((((.(.....(((........((((((...........((....((((((..........((((......((((.......))))..............((......))...))))......))))))...))....................)))))).))).....)))))....(((......)))...........)).....................(((..............)))......................)))).(......((.....(((((.........))))).(......(((...((....((((...............)))).......(((..((...((....((......))....))...))....(((..........)))....(((((((((..............((((........(((....((..............))..(.....(...((...(((((..............)))))........)).)......)........................))).........))))......................)))))))))..)))..)).................)))..(((......))).....)...(((.....(((((((..((................((((...............)))).((((((.(((........)).).))))))............((((.(......................(.((............................)).).(((.........(...((..((....((.....((......)).....))....)))).....)...........................................(((((.......)))))............)))......).)))).....))..)))))))..)))))....)........((..........))....((((((((.((..........((((.......(.......(((...((..(((.......(((((....................(.......(((((..........)))))....).....................))))).......)))...(............).....))...)))............(.....)....((((.............))))...........(((....(((((.........))))).]..................)))......(((..................))).((......))................(((.(((........)))))).................)......))))........((....((((((...((.......))...)))))).....))..................((...((.(((.(........).)))...)).((((.......))))......))..................((((((......)).)))).........))))))))))....((((((....((((....(((...................)))...(.((....((.....((((((((((.....)).)))...))))).....))..)).)...(((....(((((...........)))))....))).))))........))))))..(((.......)))....(....(((.........))).....(((.(((.(........(((......)))......)...)))..)))......).....)))..). Crystal structure of the ribosome at 5.5 A resolution.; 50S 23S RIBOSOMAL RNA 4v49 AA 1527 8.7 RF00177,RF01959,RF01960 URS000080DD60_562 12853578 0003735 0005840 562 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcggauacgcgcggccccuuggggccgugcgucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacgcaaguccaaagggggaagccuucgggucccccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaaccagggccacucauacuggcucugacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucuggcggcucaaccgcugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccuucgggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccggguaaccuacgggaagcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggauca ....<<<<....[[...>>>>.<<<<.<<<<<.<<<<<<<<<..<..<<<.<<<..<<<..<<.<<..<<<<<<<<<<....>>>>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<<....>>>>>>.....>>>>>...<<<<<....>>>>>..<<<<<<..<<....>>>>>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<..[.>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>>.<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<<<<<.......>>>>>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>.......]..<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<.....>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>....]]..<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<...<<<<<<<<<<<<<...<.<<<<......<<....>>.....>>>>.>..>>>>>>>>>>>>>...>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ....((((.........)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((((....)))))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((....))))...((((((..((....)))))))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((((((.......)))))))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))..........((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))........(((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((......(.(((....))).).....((....))....))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..((...(((.....))).))...))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((...(..((....))..)..)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))...... Crystal Structure of a Streptomycin Dependent Ribosome from E. Coli 70S Ribosome.; 16S RIBOSOMAL RNA 4v49 AV 76 8.7 RF00005 URS000011107D_562 12853578 0030533 0006412 562 gcggauuuagcucaguugggagagcgccagacugaagaucuggagguccuguguucgauccacagaauucgcacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... .((((((..((((.....[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal Structure of a Streptomycin Dependent Ribosome from E. Coli 70S Ribosome.; tRNA-Phe 4v49 AW 76 8.7 RF00005 URS000011107D_562 12853578 0030533 0006412 562 gcggauuuagcucaguugggagagcgccagacugaagaucuggagguccuguguucgauccacagaauucgcacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).(((((.......))))).....(((((..]....)))))))))))).... Crystal Structure of a Streptomycin Dependent Ribosome from E. Coli 70S Ribosome.; tRNA-Phe 4v49 B0 2825 8.7 RF02540,RF02541 URS000080DF19_562 12853578 0003735 0005840 562 ggucaagauaguaaggguccacgguggaugcccuggcgcuggagccgaugaaggacgcgauuaccugcgaaaagccccgacgagcuggagauacgcuuugacucggggauguccgaauggggaaacccaccucguaagagguauccgcaaggaugggaacucagggaacugaaacaucucaguaccugaaggagaagaaagagaauucgauuccguuaguagcggcgagcgaacccggaucagcccaaauucaaccccucaagccgaaguggcuggaaagcuacaccucagaaggugagaguccuguaggcgaacgagcgguugacuguaaggucguuguucgugaaacgaugacugaauccgcgcggaccaccgcgcaaggcuaaauacucccagugaccgauagcgcauaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaagagaaccugaaaccguggacuuacaagcagucauggcaccuuaugcguguuauggcgugccuauugaagcaugagccggcgacuuagaccugacgugcgagcuuaaguugaaaaacggaggcggagcgaaagcgaguccgaauagggcggcauuaguacgucgggcuagacucgaaaccaggugagcuaagcaugaccagguugaaacccccgugacagggggcggaggaccgaaccggugccugcugaaacagucucggaugaguuguguuuaggagugaaaagcuaaccgaaccuggagauagcuaguucuccccgaaauguauugagguacagccucggauguugaccauguccuguagagcacucacaaggcuaagggcacguaauguguucuaaaccuuaugaaacuccgaaggggcacgcguuuaguccgggagugaggcugcgagagcuaacuuccguagccgagagggaaacaacccagaccaucagcuaaggucccuaaaugaucgcucagugguuaaggaugugucgucgcauagacagccaggagguuggcuuagaagcagccacccuucaaagagugcguaauagcucacuggucgagugacgaugcgccgaaaaugaucggggcucaagugaucuaccgaagcuauggauucaacucgcgaagcgaguugucugguaggggagcguucaguccgcggagaagccauaccggaaggagugguggagccgacugaagugcggaugccggcaugaguaacgauaaaagaagugagaaucuucuucgccguaaggacaaggguuccuggggaagggucguccgcccagggaaagucgggaccuaaggugaggccgaacggcgcagccgauggacagcaggucaagauuccugcaccgaucauguggagugauggagggacgcauuacgcuauccaaugccaagcuauggcuaugcugguugguacgcucaagggcgaucgggucagaaaaucuaccggucacaugccucagacguaucgggagcuuccucggaagcgaaguuggaaacgcgacggugccaagaaaagcuucuaaacguugaaacaugauugcccguaccgcaaaccgacacagguguccgagugucaaugcacuaaggcgcgcgagagaacccucguuaaggaacuuugcaaucucaccccguaacuucggaagaagggguccccacgcuucgcguggggcgcagugaauaggcccaggcgacuguuuaccaaaaucacagcacucugccaacacgaacaguggacguauagggugugacgccugcccggugccggaaggucaaguggagcgguaagugcaagcaaagcugcgaaaugaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaggcguaacgaucugggcgcugucucaacgagggacucggugaaauugaauuggcuguaaagaugcggccuacccguagcaggacgaaaagaccccguggagcuuuacuauagucuggcauucaacguugggacguggugcguaggauaggugggaggcgaagaacccuggcuacggcuggggggagccgccggugaaauaccacccucuacucuuugacguuguaaccugaaaaaucacuuucggggaccgugcuuggcggguaguuugacuggggcggucgccucccaaaauguaacggaggcgcccaaaggucaccucaagacgguuggaaaucgucuguagagcgcaaagguagaagguggcuugacugcgagacugacacgucgagcagggaggaaacucgggcuuagugaaccggugguaccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagaguccauaucggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgcuacgggcgcaggagaauugaggggaguugcuccuaguacgagaggaccggagugaacggaccgcuggucucccugcugucguaccaacggcacaugcaggguagcuauguccggaacggauaaccgcugaaagcaucuaagcgggaagccagccccaagaugaguucucccacuguucagguaagacucccggaagaccaccggguuaagaggccaggcgugcacgcauagcaauguguucagcggacuggugcucaucagucgaggucuugacca <<<<<<<<......<<<<<<<<<<<....<<<..<<<<<<<<<<<<......<<<<<<<((..((>>>>.....<<<<<<...<<.))..))..>>......>>>>>>...>>>....<<<....>>><<<<<....>>>>><<<<....>>>>>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<......<<.....>>.....>>>>...<<<.....<<<<<<.<<<..<<<....<<<<......>>>>.((......<<<.....))>>>...>>>....>>>.>>>>>>......<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>..............<<....>>....>>.........<<<<....>>>>.............>....>>>>>>>>>>>.......<<<<<<<<<<.......>>>>>>>>>>...<.<........>.>.<<<<<<....<<<.<<<<<<<<<...<<<...<<......>>...>>>...<<....>>...<<.......>>.........>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<.....<<<<<......>>>>>......>>>...<<<..<.<<........>>.>.>>>....>>>>>>>>>>..<<.......>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<...<<<<.<<<<<....<<<...<<<.<<<<...<<<<<<<<...>>>>>>>>...>>>>.>>>..>>.>....>>>>>.>.>>>..>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<.........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>.....>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>>...<<<<<<<.....>>>>>>>.......>>>>>>..<<<<<<<.<<......<<<<<.<<....>>.>>>>>...>>.>>>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<..<.<..<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<<..>>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<...<<...<<<<....<<<<..<<<..<<<<<.<<<<.<<...[[....>>>>>>..<<<<<.<<.<<<.<<<<<<<.............>>>>>>....>>>>..>>>>>>>.....<<<<<....>>>>>....>>>>>...>>>...>>>>.........>>>>...>>......>>>>>>>>>>>>>..>>.....<<......>>.>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<<<...>>>>>>>>............<<<<<<<<<..<<...........>>..<<<<<<<.....<<<.....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<..<<....>>...>>>>>...>>...>>>>>>>>..>>>>><<<<<<<....>.>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<..<<<<<<<<<<..<<<<...........<<<<<..<<<......<<<<<<<....>>>>>>>...>>>............>>>>>..>>>>..>>>>>>>>>>...<<<<<<........>>>>>>.....>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<<<<<<<<.<.<<.......>>..>>>>>>>>..>>>>.>.......<<<<<.<.<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>...>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.]].>>>>>>...>>>>>...>>>>.>>>>>....<<.<..<<<<.............>>>>...>>>..>>>>.......>>>>>>>..<<<..>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>>>. ((((((((........(((((((((....(((..(((.((((((((......((((((.[[..[[[)))..]..((((((...((.]]..]]..))......))))))...)))....(((....)))(((((....)))))((((....))))))...((((((.....((....))......))))).).........((....))...(.((......((.....)).....)).)...(((.....((((((..((..(((...(((((......)))))[[(...).(((.....]])))...)))....))..)))))).......(((.((((.[.....)))).))).......(((((].[[[[)))))..)))......)).)))).).))..............((....))....)).........((((....)))).............)....))))))))).........((((((((((.......))))))))))...(.(........).).((((((....(((.((((((((.(..((....(((....)))....))...((....))....((.....)).........).)))))))))))..((.(...((((((...(.(((((((((..((((....(((((......)))))....).)))...((...(.((........)).)..))....))))))))).).((.......))......))))))......).))..((((((.....(.((....)).)..((.(((((..(.(((.(((((....(.(...(((.((((...(((((((.....)))))))...)))).)))..)..)....))))).).))..)))))).).)...(((((((.((......)).)))))))....(((......)))...((((.(((...((([[....(.((((((.....(.....((..((.(((((.(.......(..((.(((..(((.........)))..))).........((......))...))...)..).))))).)).))...........]].)....))))))))))...)))))))...((((((((...)))))))).......))))))(.(((.(.(.((......((((..((....))..))))...)).).).)))..).....))))))(......((.....((((((.......)))))).(((....((((..((...((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](.(((((((...((....(((....(((((.(((..(((((..(((.((...{{....)))))...(((((.(((..(..((.(((....(.....)..))).)).....).)..))))))).....(((((....)))))....)))))...)))..)))))(..).....)))....))......))))))).)))))..)).....((......)).)))).((((......))))..)))...((((....((((((((.((..(....(........((((....(.[..).....)))).((((((((...))))))))(...).......((((((.((...(...........)...(((((((.....(((.....))).......))))))).]((((.(((..((.((((..(((....(...((.((..((....))...)).))...)....)))))))...)))))((((((......).)))))........((..........(((((.......)))))..)..)....))))...))..)))))).)..))).)))))))).)))))).....).....(((((........)))))..((((((((.(((..(......((((.((((((..(((((.(((..(((..((((((((((..((((.(......[..(((((..(((......(((((((....)))))))...)))..........].)))))).))))..))))))))))...(((((((......))))))).....)))..)))..)))))..(((......[)))((((((..........])))))).[((....((((((.(.(((((.........)))))...)..(][.[[[).....))))))....((((..(((...{..)))..)))).(((....))).))]]].].....((((((..((..]]]]..)).))))))......}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......((((.((.(((..((((((((........)))))..))).(((((.....))))).....))).)..)...))).).....(((((((....))).))))....)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...(.((...(((((((((((.}}.))))))...)))))...)).).)))))....((.(..((((.............))))...)))..))))..]....)))))))..(((..)))....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))....)))))))). Crystal Structure of a Streptomycin Dependent Ribosome from E. Coli 70S Ribosome.; 23S RIBOSOMAL RNA 4v49 B9 118 8.7 RF00001 URS000080DF5C_562 12853578 0003735 0005840 562 cccccgugcccauagcacuguggaaccaccccaccccaugccgaacugggucgugaaacacagcagcgccaaugauacucggaccgcagggucccggaaaagucggucagcgcggggg <<<<<<<<<.....<<.<<<<<.....<<<<<<.............>>>>..>>....>>>>>..>><<<.<.....<<.<<<<<....>>>>>.>>.....>.>>>..>>>>>>>>> (((((((((.....((.(((((.....(((((...............)))..))....)))))..)).((.......((.(((((....))))).)).......))...))))))))) Crystal Structure of a Streptomycin Dependent Ribosome from E. Coli 70S Ribosome.; 5S RIBOSOMAL RNA 4v4a AA 1533 9.5 RF00177,RF01959,RF01960 URS000080E127_562 12853578 0003735 0005840 562 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcggauacgcgcggccccuuggggccgugcgucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacgcaaguccaaagggggaagccuucgggucccccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaaccagggccacucauacuggcucugacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucuggcggcucaaccgcugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccuucgggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccggguaaccuacgggaagcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucacuuucu ....<<<<....((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<..<<<<<<<<<<....>>>>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<<....>>>>>>.....>>>>>...<<<<<....>>>>>..<<<<<<..<<....>>>>>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<<<<<.......>>>>>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<.....>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..))))..<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<...<<<<<<<<<<<<<...<.<<<<......<<....>>.....>>>>.>..>>>>>>>>>>>>>...>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ ....((((..[.[[...)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((((....)))))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((....))))...((((((..((....)))))))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((((((.......)))))))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))....]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...((((((......(.(((....))).).....((....))....))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..((...(((.....))).))...))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((...(..((....))..)..)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Crystal Structure of the Wild Type Ribosome from E. Coli 70S Ribosome.; 16S RIBOSOMAL RNA 4v4a B0 2825 9.5 RF02540,RF02541 URS000080DF19_562 12853578 0003735 0005840 562 ggucaagauaguaaggguccacgguggaugcccuggcgcuggagccgaugaaggacgcgauuaccugcgaaaagccccgacgagcuggagauacgcuuugacucggggauguccgaauggggaaacccaccucguaagagguauccgcaaggaugggaacucagggaacugaaacaucucaguaccugaaggagaagaaagagaauucgauuccguuaguagcggcgagcgaacccggaucagcccaaauucaaccccucaagccgaaguggcuggaaagcuacaccucagaaggugagaguccuguaggcgaacgagcgguugacuguaaggucguuguucgugaaacgaugacugaauccgcgcggaccaccgcgcaaggcuaaauacucccagugaccgauagcgcauaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaagagaaccugaaaccguggacuuacaagcagucauggcaccuuaugcguguuauggcgugccuauugaagcaugagccggcgacuuagaccugacgugcgagcuuaaguugaaaaacggaggcggagcgaaagcgaguccgaauagggcggcauuaguacgucgggcuagacucgaaaccaggugagcuaagcaugaccagguugaaacccccgugacagggggcggaggaccgaaccggugccugcugaaacagucucggaugaguuguguuuaggagugaaaagcuaaccgaaccuggagauagcuaguucuccccgaaauguauugagguacagccucggauguugaccauguccuguagagcacucacaaggcuaagggcacguaauguguucuaaaccuuaugaaacuccgaaggggcacgcguuuaguccgggagugaggcugcgagagcuaacuuccguagccgagagggaaacaacccagaccaucagcuaaggucccuaaaugaucgcucagugguuaaggaugugucgucgcauagacagccaggagguuggcuuagaagcagccacccuucaaagagugcguaauagcucacuggucgagugacgaugcgccgaaaaugaucggggcucaagugaucuaccgaagcuauggauucaacucgcgaagcgaguugucugguaggggagcguucaguccgcggagaagccauaccggaaggagugguggagccgacugaagugcggaugccggcaugaguaacgauaaaagaagugagaaucuucuucgccguaaggacaaggguuccuggggaagggucguccgcccagggaaagucgggaccuaaggugaggccgaacggcgcagccgauggacagcaggucaagauuccugcaccgaucauguggagugauggagggacgcauuacgcuauccaaugccaagcuauggcuaugcugguugguacgcucaagggcgaucgggucagaaaaucuaccggucacaugccucagacguaucgggagcuuccucggaagcgaaguuggaaacgcgacggugccaagaaaagcuucuaaacguugaaacaugauugcccguaccgcaaaccgacacagguguccgagugucaaugcacuaaggcgcgcgagagaacccucguuaaggaacuuugcaaucucaccccguaacuucggaagaagggguccccacgcuucgcguggggcgcagugaauaggcccaggcgacuguuuaccaaaaucacagcacucugccaacacgaacaguggacguauagggugugacgccugcccggugccggaaggucaaguggagcgguaagugcaagcaaagcugcgaaaugaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaggcguaacgaucugggcgcugucucaacgagggacucggugaaauugaauuggcuguaaagaugcggccuacccguagcaggacgaaaagaccccguggagcuuuacuauagucuggcauucaacguugggacguggugcguaggauaggugggaggcgaagaacccuggcuacggcuggggggagccgccggugaaauaccacccucuacucuuugacguuguaaccugaaaaaucacuuucggggaccgugcuuggcggguaguuugacuggggcggucgccucccaaaauguaacggaggcgcccaaaggucaccucaagacgguuggaaaucgucuguagagcgcaaagguagaagguggcuugacugcgagacugacacgucgagcagggaggaaacucgggcuuagugaaccggugguaccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagaguccauaucggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgcuacgggcgcaggagaauugaggggaguugcuccuaguacgagaggaccggagugaacggaccgcuggucucccugcugucguaccaacggcacaugcaggguagcuauguccggaacggauaaccgcugaaagcaucuaagcgggaagccagccccaagaugaguucucccacuguucagguaagacucccggaagaccaccggguuaagaggccaggcgugcacgcauagcaauguguucagcggacuggugcucaucagucgaggucuugacca <<<<<<<<......<<<<<<<<<<<....<<<..<<<<<<<<<<<<......<<<<<<<((..((>>>>.....<<<<<<...<<.))..))..>>......>>>>>>...>>>....<<<....>>><<<<<....>>>>><<<<....>>>>>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<......<<.....>>.....>>>>...<<<.....<<<<<<.<<<..<<<....<<<<......>>>>.((......<<<.....))>>>...>>>....>>>.>>>>>>......<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>..............<<....>>....>>.........<<<<....>>>>.............>....>>>>>>>>>>>.......<<<<<<<<<<.......>>>>>>>>>>...<.<........>.>.<<<<<<....<<<.<<<<<<<<<...<<<...<<......>>...>>>...<<....>>...<<.......>>.........>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<.....<<<<<......>>>>>......>>>...<<<..<.<<........>>.>.>>>....>>>>>>>>>>..<<.......>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<...<<<<.<<<<<....<<<...<<<.<<<<...<<<<<<<<...>>>>>>>>...>>>>.>>>..>>.>....>>>>>.>.>>>..>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<.........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>.....>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>>...<<<<<<<.....>>>>>>>.......>>>>>>..<<<<<<<.<<......<<<<<.<<....>>.>>>>>...>>.>>>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<..<.<..<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<<..>>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<...<<...<<<<....<<<<..<<<..<<<<<.<<<<.<<...[[....>>>>>>..<<<<<.<<.<<<.<<<<<<<.............>>>>>>....>>>>..>>>>>>>.....<<<<<....>>>>>....>>>>>...>>>...>>>>.........>>>>...>>......>>>>>>>>>>>>>..>>.....<<......>>.>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<<<...>>>>>>>>............<<<<<<<<<..<<...........>>..<<<<<<<.....<<<.....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<..<<....>>...>>>>>...>>...>>>>>>>>..>>>>><<<<<<<....>.>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<..<<<<<<<<<<..<<<<...........<<<<<..<<<......<<<<<<<....>>>>>>>...>>>............>>>>>..>>>>..>>>>>>>>>>...<<<<<<........>>>>>>.....>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<<<<<<<<.<.<<.......>>..>>>>>>>>..>>>>.>.......<<<<<.<.<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>...>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.]].>>>>>>...>>>>>...>>>>.>>>>>....<<.<..<<<<.............>>>>...>>>..>>>>.......>>>>>>>..<<<..>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>>>. ((((((((........(((((((((....(((..(((.((((((((......((((((.[[..[[[)))..]..((((((...((.]]..]]..))......))))))...)))....(((....)))(((((....)))))((((....))))))...((((((.....((....))......))))).).........((....))...(.((......((.....)).....)).)...(((.....((((((..((..(((...(((((......)))))[[(...).(((.....]])))...)))....))..)))))).......(((.((((.[.....)))).))).......(((((].[[[[)))))..)))......)).)))).).))..............((....))....)).........((((....)))).............)....))))))))).........((((((((((.......))))))))))...(.(........).).((((((....(((.((((((((.(..((....(((....)))....))...((....))....((.....)).........).)))))))))))..((.(...((((((...(.(((((((((..((((....(((((......)))))....).)))...((...(.((........)).)..))....))))))))).).((.......))......))))))......).))..((((((.....(.((....)).)..((.(((((..(.(((.(((((....(.(...(((.((((...(((((((.....)))))))...)))).)))..)..)....))))).).))..)))))).).)...(((((((.((......)).)))))))....(((......)))...((((.(((...((([[....(.((((((.....(.....((..((.(((((.(.......(..((.(((..(((.........)))..))).........((......))...))...)..).))))).)).))...........]].)....))))))))))...)))))))...((((((((...)))))))).......))))))(.(((.(.(.((......((((..((....))..))))...)).).).)))..).....))))))(......((.....((((((.......)))))).(((....((((..((...((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](.(((((((...((....(((....(((((.(((..(((((..(((.((...{{....)))))...(((((.(((..(..((.(((....(.....)..))).)).....).)..))))))).....(((((....)))))....)))))...)))..)))))(..).....)))....))......))))))).)))))..)).....((......)).)))).((((......))))..)))...((((....((((((((.((..(....(........((((....(.[..).....)))).((((((((...))))))))(...).......((((((.((...(...........)...(((((((.....(((.....))).......))))))).]((((.(((..((.((((..(((....(...((.((..((....))...)).))...)....)))))))...)))))((((((......).)))))........((..........(((((.......)))))..)..)....))))...))..)))))).)..))).)))))))).)))))).....).....(((((........)))))..((((((((.(((..(......((((.((((((..(((((.(((..(((..((((((((((..((((.(......[..(((((..(((......(((((((....)))))))...)))..........].)))))).))))..))))))))))...(((((((......))))))).....)))..)))..)))))..(((......[)))((((((..........])))))).[((....((((((.(.(((((.........)))))...)..(][.[[[).....))))))....((((..(((...{..)))..)))).(((....))).))]]].].....((((((..((..]]]]..)).))))))......}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......((((.((.(((..((((((((........)))))..))).(((((.....))))).....))).)..)...))).).....(((((((....))).))))....)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...(.((...(((((((((((.}}.))))))...)))))...)).).)))))....((.(..((((.............))))...)))..))))..]....)))))))..(((..)))....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))....)))))))). Crystal Structure of the Wild Type Ribosome from E. Coli 70S Ribosome.; 23S RIBOSOMAL RNA 4v4a B9 118 9.5 RF00001 URS000080DF5C_562 12853578 0003735 0005840 562 cccccgugcccauagcacuguggaaccaccccaccccaugccgaacugggucgugaaacacagcagcgccaaugauacucggaccgcagggucccggaaaagucggucagcgcggggg <<<<<<<<<.....<<.<<<<<.....<<<<<<.............>>>>..>>....>>>>>..>><<<.<.....<<.<<<<<....>>>>>.>>.....>.>>>..>>>>>>>>> (((((((((.....((.(((((.....(((((...............)))..))....)))))..)).((.......((.(((((....))))).)).......))...))))))))) Crystal Structure of the Wild Type Ribosome from E. Coli 70S Ribosome.; 5S RIBOSOMAL RNA 4v4b AA 1466 11.7 RF00177,RF01959,RF01960 URS000080DDC6_4932 14976550,10404220 0003735 0005840 4932 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacgaaacccccgacgaggggacugacgguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggauca ....<<<<..{...[[.>>>>.<<<<.<<<<<..<<<<<<<...<..<<<.<<<..<<<..<<..<<<<<<.>>>>>>..>>>>>......<<.......<<<<<<<<..<<...<<<<<<..<<<<<....<<<<<<....>>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>..>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>...>.>>>>>>..<<<<......<<<<....>>>>.....>>>>..........<<<<.....>>>>.............<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..]]...}<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>..>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ....((((.........)))).((((.(((((..(((((((((....(((.(((..(((..((.(((((((.))))))).)))))......(((......((((((((..((...((((((..(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...))))..))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....)))).....(....((((.....)))).....).......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))........(((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((......(((((....))))).....))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..((...(((.....))).))...))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Structure of the ribosomal 80S-eEF2-sordarin complex from yeast obtained by docking atomic models for RNA and protein components into a 11.7 A cryo-EM map.; 18S ribosomal RNA 4v4b B3 2863 11.7 RF02540,RF00002 URS000080E33E_4932 14976550,10404220 0003735 0005840 4932 uaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagccauggggagccgcacggaggcgaagaaccauggauuuccgaaugagaaucucuacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaaugugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucucgacgaagucucuuggaacagagcgugauacagggugacaaccccguacucgagaccaguacgacgugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccucgacgaaugaccgacgcgcgagcguccaguaagacucacgggaagccgauguucugucguacguuuugaaaaacgagccagggagugugucugcauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauuggucuagggggcccaccagccuaccaaaccugucaaacuccaaacuuacagacgccguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggauguuggcuuagaagcagccaucauuuaaagagugcguaacagcucaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaaguaggggugaaaacuccuauggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucauaccgcaacucgacuaugacgaaaugggaaacggguuaauauucccgugccacuaugcagugaaaguugacgcccuggggucgaucacgcugggcaucgcccagucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcauaguguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcggccguaacuauaacgguccuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcgaagacccuauggagcuuuacugcaggcugucgcugagucuuggucggggaugcguaggauaggugggagcgcaagcgccggugaaauaccacccuuccccggcugggacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggcuaucucagccgggacggagacccggcgaagagugcaagagcaaaagauagcuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugagguuguucgccuauuaaaggaggucgugagcuggguuuagaccgucgugagacaggucggcugcuaucuacuggguguguggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaa 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...(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))()..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......(..(.....(((((((....({((((......)))))[[......(((....}]])))....)))))))......)..)...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......(...(((.....))).............)).....)))))))))......(.((((((((((....((((((..((....(....(((((....))))).....)...))..))))..)).)))))))))).{.(((........))).((((((....(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((..))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))....))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..(........((........))........)..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.......(((((.(((..(((.........)))..))).....(...((......)).).)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...((((((((((((.....))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))..(.............)..........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....}]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((............((((((.(......[..(((((..((....))..........].)))))).)))))).............((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))...((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((....)))))...))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...))))]))))..)))...)))).. Structure of the ribosomal 80S-eEF2-sordarin complex from yeast obtained by docking atomic models for RNA and protein components into a 11.7 A cryo-EM map.; 5.8S/25S ribosomal RNA 4v4b B4 122 11.7 RF00001 URS000080E074_4932 14976550,10404220 0003735 0005840 4932 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccggggaguacuggagugcgcgagccucugggaaacccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<<.............>>>>..>>....>>>>>>.>><..<<<<<.....<<<<<<.<<....>>>>>>>>....>>>>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...(((((.....((((((.((....))))))))....)))))...))))))... Structure of the ribosomal 80S-eEF2-sordarin complex from yeast obtained by docking atomic models for RNA and protein components into a 11.7 A cryo-EM map.; 5S RIBOSOMAL RNA 4v4g AA 1526 11.5 RF00177,RF01959,RF01960 URS000080E307_562 15502846 0003735 0005840 562 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcggauacgcgcggccccuuggggccgugcgucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacgcaaguccaaagggggaagccuucgggucccccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaaccagggccacucauacuggcucugacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucuggcggcucaaccgcugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccuucgggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccggguaaccuacgggaagaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggauca ....<<<<....(((..>>>>.<<<<.<<<<<..<<<<<<<......<<<.<<<..<<<..<<.....<<<<..<<<<....>>>>..>>>>...>>>>>......<<.......<<<<<<<<..<<...<<...<<....<<....<<<..........>>>.....>>........<<<....>>>......<<<<..........>>>.>..>>...>>..>>>>>>>>>><<<....<<<....<<<<..........>.>>>..>>>......>>>...<<.<<<<....>>>>....>>..>>.<<<<<............>>>>>...<<....>>.....>>>>>>.........<<<....<<<<....>>>>..>>>...>.>>>>>>..<<<<......<<<......>>>.....>>>>..<<<<<<<.........<<<<<<<.......>>>>>>>...........>>>>>.>..>.<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<.(......<<<<...<<<.<<<<<<<.<<<<.<<<<.........<<<<.....>>>>.......>>>>.>>>..>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<....<<<......>>>.......>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<.....>>>>>>>>>>>>...<<...)>>.....>>>>>>..>>.<<<......<<<<....>>>>....>>>...)))..<<<<<.<<<<<<<.<<..<<<<...<<<<<<<<<<......<<........>>..........<<<<<<.......<<<<<.<<...<.<<<<....>>>>.>..............>>.>>>>>.<<..<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<.....<...<<<.....>>>>.......>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>.>>....>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>......>>>>.....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>.......<<...<<<<.<<<..<<<<<<<<<.<<....<.<<<<..................>>>>.>...>>.>>>>>>>>>..>>>.>>>>....>>.........<<<<<<<<<....>>>>>>>>>...... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.....(((((.((((....)))).)))))...)))))......(((.......(((((((..((...(((.(((...(((....(((.(......).))).....)))........((....))........(((..((....)))))....))).)))..))))))))).(((....(((..(.((((.(.......)).))).))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.((([..(((((....))))]))))).)).))))))..((((......(((......))).....))))....((.((...(.....(((((((.......)))))))......)....)).))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((.[[...(.((((...(((.(((((((.((((.(((((......(.((((.....)))).)....))))).))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((.........))))))))))...((..]])).....))))))).)).(((......((((....))))....)))...]]].].((((.(((((((.((..(((((..((((((((.(......((........))..........(((((((......(((((........((((....)))).......(....)......)))))..(..(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((.....(....((.....)).).......))))).....(((((....)))))........)))).....).).)))...)).))).)....)))))))..[)..)))))))).(...(((((((.....(.(..((..((((....))))..))....).).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).)...(.(..((.(..(((.(((..(((.((((((((....(.((((......(......)....)))).)...)))))))).)))..))).)))...).))...)..)..(((((((((....)))))))))}..... Crystal structure of five 70s ribosomes from Escherichia Coli in complex with protein Y.; 16S ribosomal RNA 4v4g BB 2825 11.5 RF02540,RF02541 URS000080DF1F_562 15502846 0003735 0005840 562 ggucaagauaguaaggguccacgguggaugcccuggcgcuggagccgaugaaggacgcgauuaccugcgaaaagccccgacgagcuggagauacgcuuugacucggggauguccgaauggggaaacccaccucguaagagguauccgcaaggaugggaacucagggaacugaaacaucucaguaccugaaggagaagaaagagaauucgauuccguuaguagcggcgagcgaacccggaucagcccaaauucaaccccucaagccgaaguggcuggaaagcuacaccucagaaggugagaguccuguaggcgaacgagcgguugacuguaaggucguuguucgugaaacgaugacugaauccgcgcggaccaccgcgcaaggcuaaauacucccagugaccgauagcgcauaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaagagaaccugaaaccguggacuuacaagcagucauggcaccuuaugcguguuauggcgugccuauugaagcaugagccggcgacuuagaccugacgugcgagcuuaaguugaaaaacggaggcggagcgaaagcgaguccgaauagggcggcauuaguacgucgggcuagacucgaaaccaggugagcuaagcaugaccagguugaaacccccgugacagggggcggaggaccgaaccggugccugcugaaacagucucggaugaguuguguuuaggagugaaaagcuaaccgaaccuggagauagcuaguucuccccgaaauguauugagguacagccucggauguugaccauguccuguagagcacucacaaggcuaagggcacguaauguguucuaaaccuuaugaaacuccgaaggggcacgcguuuaguccgggagugaggcugcgagagcuaacuuccguagccgagagggaaacaacccagaccaucagcuaaggucccuaaaugaucgcucagugguuaaggaugugucgucgcauagacagccaggagguuggcuuagaagcagccacccuucaaagagugcguaauagcucacuggucgagugacgaugcgccgaaaaugaucggggcucaagugaucuaccgaagcuauggauucaacucgcgaagcgaguugucugguaggggagcguucaguccgcggagaagccauaccggaaggagugguggagccgacugaagugcggaugccggcaugaguaacgauaaaagaagugagaaucuucuucgccguaaggacaaggguuccuggggaagggucguccgcccagggaaagucgggaccuaaggugaggccgaacggcgcagccgauggacagcaggucaagauuccugcaccgaucauguggagugauggagggacgcauuacgcuauccaaugccaagcuauggcuaugcugguugguacgcucaagggcgaucgggucagaaaaucuaccggucacaugccucagacguaucgggagcuuccucggaagcgaaguuggaaacgcgacggugccaagaaaagcuucuaaacguugaaacaugauugcccguaccgcaaaccgacacagguguccgagugucaaugcacuaaggcgcgcgagagaacccucguuaaggaacuuugcaaucucaccccguaacuucggaagaagggguccccacgcuucgcguggggcgcagugaauaggcccaggcgacuguuuaccaaaaucacagcacucugccaacacgaacaguggacguauagggugugacgccugcccggugccggaaggucaaguggagcgguaagugcaagcaaagcugcgaaaugaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaggcguaacgaucugggcgcugucucaacgagggacucggugaaauugaauuggcuguaaagaugcggccuacccguagcaggacgaaaagaccccguggagcuuuacuauagucuggcauucaacguugagacguggugcguaggauaggugggaggcgaagaacccuggcuacggcuggggggagccgccggugaaauaccacccucuacuuuuugacguuguaaccugaaaaaucacuuucggggaccgugcuuggcggguaguuugacuggggcggucgccucccaaaauguaacggaggcgcccaaaggucaccucaagacgguuggaaaucgucuguagagcgcaaagguagaagguggcuugacugcgagacugacacgucgagcagggaggaaacucgggcuuagugaaccggugguaccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagaguccauaucggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgcuacgggcgcaggagaauugaggggaguugcuccuaguacgagaggaccggagugaacggaccgcuggucucccugcugucguaccaacggcacaugcaggguagcuauguccggaacggauaaccgcugaaagcaucuaagcgggaagccagccccaagaugaguucucccacuguucagguaagacucccggaagaccaccggguuaagaggccaggcgugcacgcauagcaauguguucagcggacuggugcucaucagucgaggucuugacca <<<<<..........<<<<<<.<<......<<..<<<<<<<<..........<<<.<<........>>......<<<<<<......................>>>>>>...>>>.....<......>.<<<........>>><<<<....>>>>.....<<<<.......<......>........>>>.>.........<<....>>...<<<.......<<.....>>......>>>...<<......<<<<<...<...<<<....<<<<......>>>>.((......<<<.....))>>>...>>>.....>...>>>>>......<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>...>>.........>>>>>>.>>..............<<....>>....>>..........<<......>>....................>>.>>>>>>........<<<<<...<.........>...>>>>>...<............>.<<<<<<....<<<.<<<<<<<<....<<<................>>>...<<....>>...<........>...........>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<.....<<<<<......>>>>>......>>>...<<<<.<.<<........>>.>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>..<<<<<.....<.<<.<<<<<<...<<....<<<.<<<<....<<.............>>....>>>>.>>>...>.>...>>>>>>.>.>.>....>>>>>.....<<<<<<<.<........>.>>>>>>>....<<<......>>>....<<<.<<<...<<<((......<<<<<............<<...<.<<<<<<.........<<<<.<<...<<<.........>>>...>>.........<<......>>...>>>>.....>>>>>>.>..>>...........)).......>>>>>.>>>...>>>>>>...<.<<.<<.......>>.>>>.......>>>>>><.<<<<<<..<<.......<<<..<<....>>..>>>....>>.>.>>>>>..>.....>>>>>>.......<<.....<<<<<.........>>>>><<<<....<<<<<.<.<.<<<<<<<...<<.....>>.>>>>>>>...<<.((...<...<<<...<<<....>>>...>>>...>.....<<............>>.>>.<..<<<<....<<...........<<<<.......<<<<..<<<..<....[[.....>.>>>....<.......<<...<<<<<.............>>>>>......>>.......>.......<..<.....>...>.....>>>>.........>>>>................>>.......>>>>..>.))....>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>...<<<....<<<<<<<..<<...............<<<<<...............>>>>><<<<...........>>>>............<<<<<<<<<..<<...........>>..<<<<<<<.....<<.......>>.......>>>>>>>.<<<<<..<...<<<<<<<..<<<........<<<.................>>>........>>>>>>>>..>>.>.<<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>.....>>..>>>>>>>.>>>.>>...........<<<<<........>>>>>..<<<<<<<<.<<..<<......<<<<.<<<<<<..<<<<..<<<.<<<<..<<<<...<<<<.<.<...............<<..<<<......<<<<<<......>>>>>>...>>>............>>......>.>.>>>>...>>>>...<<<..............>>>.....>>>>.>>>...>>>>..<<<.......>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<.<<.......>>.>>>.....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>..........<..<<<<<<....<<.......>>....>>>>>>...>...........<<<<<...<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<.......>>>>.....>>>>.......>>>.>>....<<<<<<<....>>>.>>>>....>>...>>>>>>>>>>....<<<<<<<...<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<...<<<<<<<<<<..]]..>>>>>...>>>>>...>>>>.>>>>>....<<....<<<...............>>>....>>..>>>>.......>>>>>>>................<.<<<<<.......>>>>>....<<<<<<.<..<......<<<......>>>.....>...>.>>>.>>>....>........>.>>>>. (..((..(........((((((((.....(((..(((.((((.(((......((((((..[.....))).....((((((..........]...........))))))...))).....((....)).(((........))).(((....))).))...((((.......(...[..)........))).).........((....))...(((.......((.]...))......)))...((......(((((...((..(((...(((((......)))))[[......(((.....]])))...)))....))...))))).......(((((.(.........).))))).......(((((..[[[[)))))...))......)..)))).).))..............((....))....))......(....((....))..............)).....)))))))).........(((((.((...........)).)))))...(............).((((((....(((.((.(((((....((....((......))....))...((....))....((.....))...........))))).)))))..((.(...((((((.....((((((((.(.((((.....((((......)))).....)[)))...(((..(..(........)..).)))....)))))))))...(((.....)))......))))))......).))..(((((.....(((((....))))).((((((.......((.((((((...(((...(((.((((....((.............))....)))).)))..)).)...)))))).).)......))))).)...(((((((.((......)).)))))))....(((......)))....(((..((...((([.[...(.((((((.....(.....((..(((.(((((.........((((..((..((...........))..))..........(........)...)))).....))))).))).))..........].].)....))))))))))...)).)))....(((.((.......)).)))........)))))(.((((((..((.......(.(..((....))..).)....))..))))))..).....)))))).......((.....((((.(.......).))))((((....((((..((...((((((...((.....)).))))))....[.(..(.((...(((...(((....)))...)))...)).....(............)...]((..((((....(......(.....(((...(....((((...((..((.........)).))....................(.(.............).).........................(...(....)...).....)))).....)....)))..........)......).......))))..)))..)..)).....((......)).)))).((((......))))..))))..((((....(((((((..((..(....(.......(((((....(....).....)))))(((((.........)))))(...).......(((((((((.].(...........)...(((((((.....(((.....))).......)))))))..((((.((...(((((((..(((........((((...((....))....))))........))))))))..)).))(((.(.........).)))........((..........(((((.......)))))..)..)....))))...)).))))))).)..)))..))))))).))))))...........(((((........)))))..((((((((.((..((......((((.((((((..((((..(((.((((..((((..(((((.((((.(......[..(..((..(((.......((((((....))))))....)))..........].))..)).)))).)))))..))))...(((..............))).....)))).)))...))))..(((......[)))((((((..........]))))))([((...(((((((...((..((.......))..)).....((][.[[[))....)))))))...((((..(..........)..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....).......))))..)))))).......((((...((((.(...((.......))...).))))....))).)........((((.((..((..(((((((((......))))))..))).(((((.....))))).....))..)..)...))).).....(((((((....))).))))....))...))))))))))[...(((((((...((((..(((((((.....(....)....))))))).((((....((((...(((((((((((....))))))...)))))...))))..)))).....(....((.................))....)...))))..]....)))))))....(..)........(((((((.......)))))....(((.((((..(.....(((((....)))))....)...))))..)))...))......)..))..). Crystal structure of five 70s ribosomes from Escherichia Coli in complex with protein Y.; 23S RIBOSOMAL RNA 4v4g BA 118 11.5 RF00001 URS000080E160_562 15502846 0003735 0005840 562 cccccgugcccauagcacuguggaaccaccccaccccaugccgaacugggucgugaaacacagcagcgccaaugauacucggaccgcagggucccggaaaagucggucagcgcggggg .<<<.<<<<.....<<.<<<<<....<<<<<<...............>>>..>>>...>>>>>..>><<<.......<<.<<<<<....>>>>>.>>.......>>>..>>>>>>>.. ..((..(((.....((.(((((....(((((((...(.....)...))))..)))...)))))..)).((.......(..(((((....)))))..).......))...)))..)).. Crystal structure of five 70s ribosomes from Escherichia Coli in complex with protein Y.; 5S RIBOSOMAL RNA 4v4g CA 1526 11.5 RF00177,RF01959,RF01960 URS000080E307_562 15502846 0003735 0005840 562 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcggauacgcgcggccccuuggggccgugcgucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacgcaaguccaaagggggaagccuucgggucccccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaaccagggccacucauacuggcucugacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucuggcggcucaaccgcugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccuucgggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccggguaaccuacgggaagaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggauca ....<<<<....(((..>>>>.<<<<.<<<<<..<<<<<<<......<<<.<<<..<<<..<<.....<<<<..<<<<....>>>>..>>>>...>>>>>......<<.......<<<<<<<<..<<...<<...<<....<<....<<<..........>>>.....>>........<<<....>>>......<<<<..........>>>.>..>>...>>..>>>>>>>>>><<<....<<<....<<<<..........>.>>>..>>>......>>>...<<.<<<<....>>>>....>>..>>.<<<<<............>>>>>...<<....>>.....>>>>>>.........<<<....<<<<....>>>>..>>>...>.>>>>>>..<<<<......<<<......>>>.....>>>>..<<<<<<<.........<<<<<<<.......>>>>>>>...........>>>>>.>..>.<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<.(......<<<<...<<<.<<<<<<<.<<<<.<<<<.........<<<<.....>>>>.......>>>>.>>>..>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<....<<<......>>>.......>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<.....>>>>>>>>>>>>...<<...)>>.....>>>>>>..>>.<<<......<<<<....>>>>....>>>...)))...<<<<.<<<<<<<.<<..<<<<...<<<<<<<<<<......<<........>>..........<<<<<<.......<<<<<.<<...<.<<<<....>>>>.>..............>>.>>>>>.<<..<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<.....<...<<<.....>>>>.......>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>.>>....>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>......>>>>.....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>........<<...<<<<.<<<..<<<<<<<<<.<<....<.<<<<..................>>>>.>...>>.>>>>>>>>>..>>>.>>>>....>>.........<<<<.<<<<....>>>>.>>>>...... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.....(((((.((((....)))).)))))...)))))......(((.......(((((((..((...(((.(((...(((....(((.(......).))).....)))........((....))........(((..((....)))))....))).)))..))))))))).(((.[..(((..(.((((.(.......)).))).))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.((([..(((((....))))]))))).)).))))))..((((......(((......))).....))))....((.((...(.....(((((((.......)))))))......)....)).))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((.[[...(.((((...(((.(((((((.((((.(((((......(.((((.....)))).)....))))).))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((.........))))))))))...((..]])).....))))))).)).(((....].((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((.(......((........))..........(((((((......(((((........((((....)))).......(....)......)))))..(..(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((.....(....((.....)).).......))))).....(((((....)))))........)))).....).).)))...)).))).)....)))))))..[)..)))))))).(...(((((((.....(.(..((..((((....))))..))....).).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(..(((.(((..(((.((((((((....(.((((......(......)....)))).)...)))))))).)))..))).)))...).))...)..)..(((((((((....)))))))))}..... Crystal structure of five 70s ribosomes from Escherichia Coli in complex with protein Y.; 16S ribosomal RNA 4v4g DB 2825 11.5 RF02540,RF02541 URS000080DF1F_562 15502846 0003735 0005840 562 ggucaagauaguaaggguccacgguggaugcccuggcgcuggagccgaugaaggacgcgauuaccugcgaaaagccccgacgagcuggagauacgcuuugacucggggauguccgaauggggaaacccaccucguaagagguauccgcaaggaugggaacucagggaacugaaacaucucaguaccugaaggagaagaaagagaauucgauuccguuaguagcggcgagcgaacccggaucagcccaaauucaaccccucaagccgaaguggcuggaaagcuacaccucagaaggugagaguccuguaggcgaacgagcgguugacuguaaggucguuguucgugaaacgaugacugaauccgcgcggaccaccgcgcaaggcuaaauacucccagugaccgauagcgcauaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaagagaaccugaaaccguggacuuacaagcagucauggcaccuuaugcguguuauggcgugccuauugaagcaugagccggcgacuuagaccugacgugcgagcuuaaguugaaaaacggaggcggagcgaaagcgaguccgaauagggcggcauuaguacgucgggcuagacucgaaaccaggugagcuaagcaugaccagguugaaacccccgugacagggggcggaggaccgaaccggugccugcugaaacagucucggaugaguuguguuuaggagugaaaagcuaaccgaaccuggagauagcuaguucuccccgaaauguauugagguacagccucggauguugaccauguccuguagagcacucacaaggcuaagggcacguaauguguucuaaaccuuaugaaacuccgaaggggcacgcguuuaguccgggagugaggcugcgagagcuaacuuccguagccgagagggaaacaacccagaccaucagcuaaggucccuaaaugaucgcucagugguuaaggaugugucgucgcauagacagccaggagguuggcuuagaagcagccacccuucaaagagugcguaauagcucacuggucgagugacgaugcgccgaaaaugaucggggcucaagugaucuaccgaagcuauggauucaacucgcgaagcgaguugucugguaggggagcguucaguccgcggagaagccauaccggaaggagugguggagccgacugaagugcggaugccggcaugaguaacgauaaaagaagugagaaucuucuucgccguaaggacaaggguuccuggggaagggucguccgcccagggaaagucgggaccuaaggugaggccgaacggcgcagccgauggacagcaggucaagauuccugcaccgaucauguggagugauggagggacgcauuacgcuauccaaugccaagcuauggcuaugcugguugguacgcucaagggcgaucgggucagaaaaucuaccggucacaugccucagacguaucgggagcuuccucggaagcgaaguuggaaacgcgacggugccaagaaaagcuucuaaacguugaaacaugauugcccguaccgcaaaccgacacagguguccgagugucaaugcacuaaggcgcgcgagagaacccucguuaaggaacuuugcaaucucaccccguaacuucggaagaagggguccccacgcuucgcguggggcgcagugaauaggcccaggcgacuguuuaccaaaaucacagcacucugccaacacgaacaguggacguauagggugugacgccugcccggugccggaaggucaaguggagcgguaagugcaagcaaagcugcgaaaugaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaggcguaacgaucugggcgcugucucaacgagggacucggugaaauugaauuggcuguaaagaugcggccuacccguagcaggacgaaaagaccccguggagcuuuacuauagucuggcauucaacguugagacguggugcguaggauaggugggaggcgaagaacccuggcuacggcuggggggagccgccggugaaauaccacccucuacuuuuugacguuguaaccugaaaaaucacuuucggggaccgugcuuggcggguaguuugacuggggcggucgccucccaaaauguaacggaggcgcccaaaggucaccucaagacgguuggaaaucgucuguagagcgcaaagguagaagguggcuugacugcgagacugacacgucgagcagggaggaaacucgggcuuagugaaccggugguaccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagaguccauaucggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgcuacgggcgcaggagaauugaggggaguugcuccuaguacgagaggaccggagugaacggaccgcuggucucccugcugucguaccaacggcacaugcaggguagcuauguccggaacggauaaccgcugaaagcaucuaagcgggaagccagccccaagaugaguucucccacuguucagguaagacucccggaagaccaccggguuaagaggccaggcgugcacgcauagcaauguguucagcggacuggugcucaucagucgaggucuugacca <<<<<<<<.......<<<<<<.<<......<<..<<<<<<<<..<<......<<<.<<........>>......<<<<<<......................>>>>>>...>>>.....<......>.<<<........>>><<<<....>>>>>>...<<<<.......<......>........>>>.>.........<<....>>...<<<.......<<.....>>......>>>...<<......<<<<<...<...<<<....<<<<......>>>>.((......<<<.....))>>>...>>>.....>...>>>>>......<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>...>>.........>>>>>>.>>..............<<....>>....>>..........<<......>>....................>>.>>>>>>........<<<<<...<.........>...>>>>>...<............>.<<<<<<....<<<.<<.<<<<<....<<<................>>>...<<....>>...<........>...........>>>>>.>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<.....<<<<<......>>>>>......>>>...<<<<.<.<<........>>.>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>..<<<<<.....<.<<.<<<<<<...<<....<<<..<<<....<<.............>>....>>>..>>>...>.>...>>>>>>.>.>.>....>>>>>.....<<<<<<<.<........>.>>>>>>>....<<<......>>>....<<<.<<<...<<<((......<<<<<............<<...<.<<<<<<........<<<<<.<<...<<<.........>>>...>>.........<<......>>...>>>>>....>>>>>>.>..>>...........)).......>>>>>.>>>...>>>>>>...<.<<.<<.......>>.>>>.......>>>>>><.<<<<<<..<<.......<<<..<<....>>..>>>....>>.>.>>>>>..>.....>>>>>>.......<<.....<<<<<.........>>>>><<<<....<<<<<.<.<.<<<<<<<...<<.....>>.>>>>>>>...<<.((...<...<<<...<<<....>>>...>>>...>.....<<<..........>>>.>>.<..<<<<....<<...........<<<<.......<<<<..<<<..<....[[.....>.>>>..<.<.......<<...<<<<<.............>>>>>......>>.......>.>.....<..<.....>...>.....>>>>.........>>>>................>>.......>>>>..>.))....>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>...<<<....<<<<<<<..<<...............<<<<<...............>>>>><<<<...........>>>>............<<<<<<<<<..<<...........>>..<<<<<<<.....<<.......>>.......>>>>>>>.<<<<<..<...<<<<<<<..<<<........<<<.................>>>........>>>>>>>>..>>.>.<<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>.....>>..>>>>>>>.>>>.>>...........<<<<<........>>>>>..<<<<<<<<.<<..<<......<<<<.<<<<<<..<<<<..<<<.<<<<..<<<<...<<<<.<.<...............<<..<<<......<<<<<<......>>>>>>...>>>............>>......>.>.>>>>...>>>>...<<<..............>>>.....>>>>.>>>...>>>>..<<<.......>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<.<<.......>>.>>>.....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>..........<..<<<<<<....<<.......>>....>>>>>>...>...........<<<<<...<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>.......>>>.>>....<<<<<<<....>>>.>>>>....>>...>>>>>>>>>>....<<<<<<<...<<<<...<<<<<<...............>>>>>>..<<<<....<<<<...<<<<<<<<<<..]]..>>>>>...>>>>>...>>>>..>>>>..........<<<...............>>>........>>>>.......>>>>>>>................<.<<<<<.......>>>>>....<<<<<<.<..<......<<<......>>>.....>...>.>>>.>>>....>......>>>>>>>>. ((((((..........((((((((.....(((..(((.((((.(((......((((((..[.....))).....((((((..........]...........))))))...))).....((....)).(((........))).(((....))).))...((((.......(...[..)........))).).........((....))...(((.......((.]...))......)))...((......(((((...((..(((...(((((......)))))[[......(((.....]])))...)))....))...))))).......(((((.(.........).))))).......(((((..[[[[)))))...))......)..)))).).))..............((....))....))......(....((....))..............)).....)))))))).........(((((.((...........)).)))))...(............).((((((....(((.((.(((((....((....((......))....))...((....))....((.....))...........))))).)))))..((.(...((((((.....((((((((.(.((((.....((((......)))).....)[)))...(((..(..(........)..).)))....)))))))))...(((.....)))......))))))......).))..(((((.....(((((....))))).((((((.......((.((((((...(((...(((.((((....((.............))....)))).)))..)).)...)))))).).)......))))).)...(((((((.((......)).)))))))....(((......)))...((((..((...((([.[...(.((((((.....(.....((..((...((((.........((((..((..((...........))..))..........(........)...)))).....))))...)).))..........].].)....))))))))))...)).))))...(((.((.......)).)))........)))))(.((((((..((.......(.(..((....))..).)....))..))))))..).....)))))).......((.....((((.(.......).))))((((....((((..((...((((((...((.....)).))))))....(([..[.((...(((...(((....)))...)))...))....(((..........))).))((..((((....(.......(....(((...(....((((...((..((.........)).)).....(((............(.(.............).)...............))).......(...(....)...).....)))).....)....)))..........)......).......))))..))]..]..)).....((......)).)))).((((......))))..))))..((((....(((((((..((..(....(.......(((((....(....).....)))))(((((.........)))))(...).......(((((((((.].(...........)...(((((((.....(((.....))).......)))))))..((((.((...(((((((..(((........((((...((....))....))))........))))))))..)).))(((.(.........).)))........((..........(((((.......)))))..)..)....))))...)).))))))).)..)))..))))))).))))))...........(((((........)))))..((((((((.((..((......((((.((((((..((((..(((.((((..((((..(((((.((((.(......[..(..((..(((.......((((((....))))))....)))..........].))..)).)))).)))))..))))...(((..............))).....)))).)))...))))..(((......[)))((((((..........]))))))([((...(((((((...((..((.......))..)).....((][.[[[))....)))))))...((((..(..........)..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....).......))))..)))))).......(.((...((((.(...((.......))...).))))....))..)........((((.((..((..(((((((((......))))))..))).(((((.....))))).....))..)..)...))).).....(((((((....))).))))....))...))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((....))))))...)))))...)))).))))).....(....((.................))....)...))))..]....)))))))....(..)........(((((((.......)))))....(((.((((..(.....(((((....)))))....)...))))..)))...))........)))))). Crystal structure of five 70s ribosomes from Escherichia Coli in complex with protein Y.; 23S RIBOSOMAL RNA 4v4g DA 118 11.5 RF00001 URS000080E160_562 15502846 0003735 0005840 562 cccccgugcccauagcacuguggaaccaccccaccccaugccgaacugggucgugaaacacagcagcgccaaugauacucggaccgcagggucccggaaaagucggucagcgcggggg .<<<.<<<<.....<<.<<<<<....<<<<<<...............>>>..>>>...>>>>>..>><<<.......<<.<<<<<....>>>>>.>>.......>>>..>>>>>>>.. ..((..(((.....((.(((((....(((((((...(.....)...))))..)))...)))))..)).((.......(..(((((....)))))..).......))...)))..)).. Crystal structure of five 70s ribosomes from Escherichia Coli in complex with protein Y.; 5S RIBOSOMAL RNA 4v4g EA 1526 11.5 RF00177,RF01959,RF01960 URS000080E307_562 15502846 0003735 0005840 562 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcggauacgcgcggccccuuggggccgugcgucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacgcaaguccaaagggggaagccuucgggucccccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaaccagggccacucauacuggcucugacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucuggcggcucaaccgcugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccuucgggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccggguaaccuacgggaagaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggauca ....<<<<....{[[..>>>>.<<<<.<<<<<..<<<<<<<......<<<.<<<..<<<..<<.....<<<<..<<<<....>>>>..>>>>...>>>>>......<<.......<<<<<<<<..<<...<<...<<....<<....<<<..........>>>.....>>........<<<....>>>......<<<<..........>>>.>..>>...>>..>>>>>>>>>><<<....<<<....<<<<..........>.>>>..>>>......>>>...<<.<<<<....>>>>....>>..>>.<<<<<............>>>>>...<<....>>.....>>>>>>.........<<<....<<<<....>>>>..>>>...>.>>>>>>..<<<<......<<<......>>>.....>>>>..<<<<<<<.........<<<<<<<.......>>>>>>>...........>>>>>.>..>.<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<.(......<<<<...<<<.<<<<<<<.<<<<.<<<<.........<<<<.....>>>>.......>>>>.>>>..>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<....<<<......>>>.......>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<.....>>>>>>>>>>>>...<<...)>>.....>>>>>>..>>.<<<......<<<<....>>>>....>>>...]].}...<<<.<<<<<<<.<<..<<<<...<<<<<<<<<<......<<........>>..........<<<<<<.......<<<<<.<<...<.<<<<....>>>>.>..............>>.>>>>>.<<..<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<.....<...<<<.....>>>>.......>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>.>>....>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>......>>>>.....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>..........<<...<<<<.<<<..<<<<<<<<<.<<....<.<<<<..................>>>>.>...>>.>>>>>>>>>..>>>.>>>>....>>.........<<<<.<<<<....>>>>.>>>>...... ....((((....[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.....(((((.((((....)))).)))))...)))))......(((.......(((((((..((...(((.(((...(((....(((.(......).))).....)))........((....))........(((..((....)))))....))).)))..))))))))).(((.[..(((..(.((((.(.......)).))).))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.((([..(((((....))))]))))).)).))))))..((((......(((......))).....))))....((.((...(.....(((((((.......)))))))......)....)).))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((.[[...(.((((...(((.(((((((.((((.(((((......(.((((.....)))).)....))))).))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((.........))))))))))...((..]])).....))))))).)).(((....].((((....))))....)))...]]]....(((.(((((((.((..(((((..((((((((.(......((........))..........(((((((......(((((........((((....)))).......(....)......)))))..(..(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((.....(....((.....)).).......))))).....(((((....)))))........)))).....).).)))...)).))).)....)))))))..[)..)))))))).(...(((((((.....(.(..((..((((....))))..))....).).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).....(.(..((.(..(((.(((..(((.((((((((....(.((((......(......)....)))).)...)))))))).)))..))).)))...).))...)..)..(((((((((....)))))))))}..... Crystal structure of five 70s ribosomes from Escherichia Coli in complex with protein Y.; 16S ribosomal RNA 4v4g FB 2825 11.5 RF02540,RF02541 URS000080DF1F_562 15502846 0003735 0005840 562 ggucaagauaguaaggguccacgguggaugcccuggcgcuggagccgaugaaggacgcgauuaccugcgaaaagccccgacgagcuggagauacgcuuugacucggggauguccgaauggggaaacccaccucguaagagguauccgcaaggaugggaacucagggaacugaaacaucucaguaccugaaggagaagaaagagaauucgauuccguuaguagcggcgagcgaacccggaucagcccaaauucaaccccucaagccgaaguggcuggaaagcuacaccucagaaggugagaguccuguaggcgaacgagcgguugacuguaaggucguuguucgugaaacgaugacugaauccgcgcggaccaccgcgcaaggcuaaauacucccagugaccgauagcgcauaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaagagaaccugaaaccguggacuuacaagcagucauggcaccuuaugcguguuauggcgugccuauugaagcaugagccggcgacuuagaccugacgugcgagcuuaaguugaaaaacggaggcggagcgaaagcgaguccgaauagggcggcauuaguacgucgggcuagacucgaaaccaggugagcuaagcaugaccagguugaaacccccgugacagggggcggaggaccgaaccggugccugcugaaacagucucggaugaguuguguuuaggagugaaaagcuaaccgaaccuggagauagcuaguucuccccgaaauguauugagguacagccucggauguugaccauguccuguagagcacucacaaggcuaagggcacguaauguguucuaaaccuuaugaaacuccgaaggggcacgcguuuaguccgggagugaggcugcgagagcuaacuuccguagccgagagggaaacaacccagaccaucagcuaaggucccuaaaugaucgcucagugguuaaggaugugucgucgcauagacagccaggagguuggcuuagaagcagccacccuucaaagagugcguaauagcucacuggucgagugacgaugcgccgaaaaugaucggggcucaagugaucuaccgaagcuauggauucaacucgcgaagcgaguugucugguaggggagcguucaguccgcggagaagccauaccggaaggagugguggagccgacugaagugcggaugccggcaugaguaacgauaaaagaagugagaaucuucuucgccguaaggacaaggguuccuggggaagggucguccgcccagggaaagucgggaccuaaggugaggccgaacggcgcagccgauggacagcaggucaagauuccugcaccgaucauguggagugauggagggacgcauuacgcuauccaaugccaagcuauggcuaugcugguugguacgcucaagggcgaucgggucagaaaaucuaccggucacaugccucagacguaucgggagcuuccucggaagcgaaguuggaaacgcgacggugccaagaaaagcuucuaaacguugaaacaugauugcccguaccgcaaaccgacacagguguccgagugucaaugcacuaaggcgcgcgagagaacccucguuaaggaacuuugcaaucucaccccguaacuucggaagaagggguccccacgcuucgcguggggcgcagugaauaggcccaggcgacuguuuaccaaaaucacagcacucugccaacacgaacaguggacguauagggugugacgccugcccggugccggaaggucaaguggagcgguaagugcaagcaaagcugcgaaaugaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaggcguaacgaucugggcgcugucucaacgagggacucggugaaauugaauuggcuguaaagaugcggccuacccguagcaggacgaaaagaccccguggagcuuuacuauagucuggcauucaacguugagacguggugcguaggauaggugggaggcgaagaacccuggcuacggcuggggggagccgccggugaaauaccacccucuacuuuuugacguuguaaccugaaaaaucacuuucggggaccgugcuuggcggguaguuugacuggggcggucgccucccaaaauguaacggaggcgcccaaaggucaccucaagacgguuggaaaucgucuguagagcgcaaagguagaagguggcuugacugcgagacugacacgucgagcagggaggaaacucgggcuuagugaaccggugguaccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagaguccauaucggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgcuacgggcgcaggagaauugaggggaguugcuccuaguacgagaggaccggagugaacggaccgcuggucucccugcugucguaccaacggcacaugcaggguagcuauguccggaacggauaaccgcugaaagcaucuaagcgggaagccagccccaagaugaguucucccacuguucagguaagacucccggaagaccaccggguuaagaggccaggcgugcacgcauagcaauguguucagcggacuggugcucaucagucgaggucuugacca <.<<<.<<.......<<<<<<.<<......<<..<<<<<<<<..<<......<<<.<<......(.>>......<<<<<<......)...............>>>>>>...>>>.....<......>.<<<........>>><<<<....>>>>>>...<<<<.......<......>........>>>.>.........<<....>>...<<<.......<<.....>>......>>>...<<......<<<<<...<...<<<....<<<<......>>>>.((......<<<.....))>>>...>>>.....>...>>>>>......<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>...>>.........>>>>>>.>>..............<<....>>....>>..........<<......>>....................>>.>>>>>>.........<<<<...<.........>...>>>>....<............>.<<<<<<....<<<.<..<<<<<....<<<................>>>...<<....>>...<........>...........>>>>>.>.>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<.....<<<<<......>>>>>......>>>...<<<<.<.<<........>>.>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>..<<<<<.....<.<<.<<<<<<...<<....<<<..<<<....<<.............>>....>>>..>>>...>.>...>>>>>>.>.>.>....>>>>>.....<<<<<<<.<........>.>>>>>>>....<<<......>>>...<<<<.<<<...<<<((......<<<<<............<<...<<<<<<<<........<<<<<.<<...<<<.........>>>...>>.........<<......>>...>>>>>....>>>>>>>>..>>...........)).......>>>>>.>>>...>>>>>>>..<.<<.<<.......>>.>>>.......>>>>>><.<<<<<<..<<.......<<<..<<....>>..>>>....>>.>.>>>>>..>.....>>>>>>.......<<.....<<<<<.........>>>>><<<<....<<<<<.<.<.<<<<<<<...<<.....>>.>>>>>>>......<<...<...<<<...<<<....>>>...>>>...>......<<..........>>.....<..<<<<....<<...........<<<<.......<<<<..<<<..<....[[.....>.>>>....<<......<<...<<<<<.............>>>>>......>>......>>.......<..<.....>...>.....>>>>.........>>>>................>>.......>>>>..>.>>....>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>...<<<....<<<<<<<..<<...............<<<<<...............>>>>><<<<...........>>>>............<<<<<<<<<..<<...........>>..<<<<<<<.....<<.......>>.......>>>>>>>.<<<<<..<...<<<<<<<..<<<........<<<.................>>>........>>>>>>>>..>>.>.<<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>.....>>..>>>>>>>.>>>.>>...........<<<<<........>>>>>..<<<<<<<<.<<..<<......<<<<.<<<<<<..<<<<..<<<.<<<<..<<<<...<<<<.<.<...............<<..<<<......<<<<<<......>>>>>>...>>>............>>......>.>.>>>>...>>>>...<<<..............>>>.....>>>>.>>>...>>>>..<<<.......>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<.<<.......>>.>>>.....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>..........<..<<<<<<....<<.......>>....>>>>>>...>...........<<<<<...<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>.......>>>.>>....<<<<<<<....>>>.>>>>....>>...>>>>>>>>>>....<<<<<<<...<<<<...<<<<<<...............>>>>>>..<<<<....<<<<...<<<<<<<<<<..]]..>>>>>...>>>>>...>>>>..>>>>..........<<<...............>>>........>>>>.......>>>>>>>................<.<<<<<.......>>>>>....<<<<<<.<..<......<<<......>>>.....>...>.>>>.>>>....>......>>.>>>.>. .((((...........((((((((.....(((..(((.((((.(((......((((((..[.....))).....((((((..........]...........))))))...))).....((....)).(((........))).(((....))).))...((((.......(...[..)........))).).........((....))...(((.......((.]...))......)))...((......(((((...((..(((...(((((......)))))[[......(((.....]])))...)))....))...))))).......(((((.(.........).))))).......(((((..[[[[)))))...))......)..)))).).))..............((....))....))......(....((....))..............)).....)))))))).........(((((.((...........)).)))))...(............).((((((....(((.(.((((((....((....((......))....))...((....))....((.....))...........))))).)))))..((.(...((((((.....((((((((.(.((((.....((((......)))).....)[)))...(((..(..(........)..).)))....)))))))))...(((.....)))......))))))......).))..(((((.....(((((....))))).((((((.......((.((((((...(((...(((.((((....((.............))....)))).)))..)).)...)))))).).)......))))).)...(((((((.((......)).)))))))....(((......)))...(((..(((...((([.[...(.((((((.....(.....((..(((..((((.........((((..((..((...........))..))..........(........)...)))).....))))..))).))..........].].)....))))))))))...))).)))...(((.((.......)).)))........)))))(.((((((..((.......(.(..((....))..).)....))..))))))..).....)))))).......((.....((((.(.......).))))((((....((((..((...((((((...((.....)).))))))......(..(.((...(((...(((....)))...)))...)).......................((..((((....(......(.....(((...(....((((...((..((...{.....)).))....................(.(.............).).........................(...(....)...).....)))).....)....)))..........)......).......))))..)))..)..)).....((......)).)))).((((......))))..))))..((((....(((((((..((..(....(.......(((((....(....).....)))))(((((.........)))))(...).......(((((((((.].(...........)...(((((((.....(((.....))).......)))))))..((((.((...(((((((..(((........((((...((....))....))))........))))))))..)).))(((.(.........).)))........((..........(((((.......)))))..)..)....))))...)).))))))).)..)))..))))))).))))))...........(((((........)))))..((((((((.((..((......((((.((((((..((((..(((.((((..((((..(((((.((((.(......[..(..((..(((.......((((((....))))))....)))..........].))..)).)))).)))))..))))...(((..............))).....)))).)))...))))..(((......[)))((((((..........]))))))([((...(((((((...((..((.......))..)).....((][.[[[))....)))))))...((((..(.....{....)..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..)))))).......((((...((((.(...((.......))...).))))....))).)........((((.((..((..(((((((((......))))))..))).(((((.....))))).....))..)..)...))).).....(((((((....))).))))....))...))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(.(((...((((...(((((((((((..}.))))))...)))))...)))).)).))..........((.................))........))))..]....)))))))................(((((((.......)))))....(((.((((..(.....(((((....)))))....)...))))..)))...)).........)))).. Crystal structure of five 70s ribosomes from Escherichia Coli in complex with protein Y.; 23S RIBOSOMAL RNA 4v4g FA 118 11.5 RF00001 URS000080E160_562 15502846 0003735 0005840 562 cccccgugcccauagcacuguggaaccaccccaccccaugccgaacugggucgugaaacacagcagcgccaaugauacucggaccgcagggucccggaaaagucggucagcgcggggg .<<<.<<<<.....<<.<<<<<....<<<<<<...............>>>..>>>...>>>>>..>><<<.......<<.<<<<<....>>>>>.>>.......>>>..>>>>>>>.. ..((..(((.....((.(((((....(((((((...(.....)...))))..)))...)))))..)).((.......(..(((((....)))))..).......))...)))..)).. Crystal structure of five 70s ribosomes from Escherichia Coli in complex with protein Y.; 5S RIBOSOMAL RNA 4v4g GA 1526 11.5 RF00177,RF01959,RF01960 URS000080E307_562 15502846 0003735 0005840 562 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcggauacgcgcggccccuuggggccgugcgucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacgcaaguccaaagggggaagccuucgggucccccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaaccagggccacucauacuggcucugacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucuggcggcucaaccgcugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccuucgggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccggguaaccuacgggaagaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggauca ....<<<<....(((..>>>>.<<<<.<<<<<..<<<<<<<......<<<.<<<..<<<..<<.....<<<<..<<<<....>>>>..>>>>...>>>>>......<<.......<<<<<<<<..<<...<<...<<....<<....<<<..........>>>.....>>........<<<....>>>......<<<<..........>>>.>..>>...>>..>>>>>>>>>><<<....<<<....<<<<..........>.>>>..>>>......>>>...<<.<<<<....>>>>....>>..>>.<<<<<............>>>>>...<<....>>.....>>>>>>.........<<<....<<<<....>>>>..>>>...>.>>>>>>..<<<<......<<<......>>>.....>>>>..<<<<<<<.........<<<<<<<.......>>>>>>>...........>>>>>.>..>.<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<.(......<<<<...<<<.<<<<<<<.<<<<.<<<<.........<<<<.....>>>>.......>>>>.>>>..>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<....<<<......>>>.......>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<.....>>>>>>>>>>>>...<<...)>>.....>>>>>>..>>.<<<......<<<<....>>>>....>>>...)))..<<<<<.<<<<<<<.<<..<<<<...<<<<<<<<<<......<<........>>..........<<<<<<.......<<<<<.<<...<.<<<<....>>>>.>..............>>.>>>>>.<<..<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<.....<...<<<.....>>>>.......>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>.>>....>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>......>>>>.....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>.......<<...<<<<.<<<..<<<<<<<<<.<<....<.<<<<..................>>>>.>...>>.>>>>>>>>>..>>>.>>>>....>>.........<<<<.<<<<....>>>>.>>>>...... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.....(((((.((((....)))).)))))...)))))......(((.......(((((((..((...(((.(((...(((....(((.(......).))).....)))........((....))........(((..((....)))))....))).)))..))))))))).(((....(((..(.((((.(.......)).))).))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.((([..(((((....))))]))))).)).))))))..((((......(((......))).....))))....((.((...(.....(((((((.......)))))))......)....)).))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((.[[...(.((((...(((.(((((((.((((.(((((......(.((((.....)))).)....))))).))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((.........))))))))))...((..]])).....))))))).)).(((......((((....))))....)))...]]].].((((.(((((((.((..(((((..((((((((.(......((........))..........(((((((......(((((........((((....)))).......(....)......)))))..(..(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((.....(....((.....)).).......))))).....(((((....)))))........)))).....).).)))...)).))).)....)))))))..[)..)))))))).(...(((((((.....(.(..((..((((....))))..))....).).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).)...(.(..((.(..(((.(((..(((.((((((((....(.((((......(......)....)))).)...)))))))).)))..))).)))...).))...)..)..(((((((((....)))))))))}..... Crystal structure of five 70s ribosomes from Escherichia Coli in complex with protein Y.; 16S ribosomal RNA 4v4g HB 2825 11.5 RF02540,RF02541 URS000080DF1F_562 15502846 0003735 0005840 562 ggucaagauaguaaggguccacgguggaugcccuggcgcuggagccgaugaaggacgcgauuaccugcgaaaagccccgacgagcuggagauacgcuuugacucggggauguccgaauggggaaacccaccucguaagagguauccgcaaggaugggaacucagggaacugaaacaucucaguaccugaaggagaagaaagagaauucgauuccguuaguagcggcgagcgaacccggaucagcccaaauucaaccccucaagccgaaguggcuggaaagcuacaccucagaaggugagaguccuguaggcgaacgagcgguugacuguaaggucguuguucgugaaacgaugacugaauccgcgcggaccaccgcgcaaggcuaaauacucccagugaccgauagcgcauaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaagagaaccugaaaccguggacuuacaagcagucauggcaccuuaugcguguuauggcgugccuauugaagcaugagccggcgacuuagaccugacgugcgagcuuaaguugaaaaacggaggcggagcgaaagcgaguccgaauagggcggcauuaguacgucgggcuagacucgaaaccaggugagcuaagcaugaccagguugaaacccccgugacagggggcggaggaccgaaccggugccugcugaaacagucucggaugaguuguguuuaggagugaaaagcuaaccgaaccuggagauagcuaguucuccccgaaauguauugagguacagccucggauguugaccauguccuguagagcacucacaaggcuaagggcacguaauguguucuaaaccuuaugaaacuccgaaggggcacgcguuuaguccgggagugaggcugcgagagcuaacuuccguagccgagagggaaacaacccagaccaucagcuaaggucccuaaaugaucgcucagugguuaaggaugugucgucgcauagacagccaggagguuggcuuagaagcagccacccuucaaagagugcguaauagcucacuggucgagugacgaugcgccgaaaaugaucggggcucaagugaucuaccgaagcuauggauucaacucgcgaagcgaguugucugguaggggagcguucaguccgcggagaagccauaccggaaggagugguggagccgacugaagugcggaugccggcaugaguaacgauaaaagaagugagaaucuucuucgccguaaggacaaggguuccuggggaagggucguccgcccagggaaagucgggaccuaaggugaggccgaacggcgcagccgauggacagcaggucaagauuccugcaccgaucauguggagugauggagggacgcauuacgcuauccaaugccaagcuauggcuaugcugguugguacgcucaagggcgaucgggucagaaaaucuaccggucacaugccucagacguaucgggagcuuccucggaagcgaaguuggaaacgcgacggugccaagaaaagcuucuaaacguugaaacaugauugcccguaccgcaaaccgacacagguguccgagugucaaugcacuaaggcgcgcgagagaacccucguuaaggaacuuugcaaucucaccccguaacuucggaagaagggguccccacgcuucgcguggggcgcagugaauaggcccaggcgacuguuuaccaaaaucacagcacucugccaacacgaacaguggacguauagggugugacgccugcccggugccggaaggucaaguggagcgguaagugcaagcaaagcugcgaaaugaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaggcguaacgaucugggcgcugucucaacgagggacucggugaaauugaauuggcuguaaagaugcggccuacccguagcaggacgaaaagaccccguggagcuuuacuauagucuggcauucaacguugagacguggugcguaggauaggugggaggcgaagaacccuggcuacggcuggggggagccgccggugaaauaccacccucuacuuuuugacguuguaaccugaaaaaucacuuucggggaccgugcuuggcggguaguuugacuggggcggucgccucccaaaauguaacggaggcgcccaaaggucaccucaagacgguuggaaaucgucuguagagcgcaaagguagaagguggcuugacugcgagacugacacgucgagcagggaggaaacucgggcuuagugaaccggugguaccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagaguccauaucggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgcuacgggcgcaggagaauugaggggaguugcuccuaguacgagaggaccggagugaacggaccgcuggucucccugcugucguaccaacggcacaugcaggguagcuauguccggaacggauaaccgcugaaagcaucuaagcgggaagccagccccaagaugaguucucccacuguucagguaagacucccggaagaccaccggguuaagaggccaggcgugcacgcauagcaauguguucagcggacuggugcucaucagucgaggucuugacca <<<<<<.........<<<<<<.<<......<<..<<<<<<<<...<......<<<.<<........>>......<<<<<<......................>>>>>>...>>>.....<......>.<<<........>>><<<<....>>>>>....<<<<.......<......>........>>>.>.........<<....>>...<<<.......<<.....>>......>>>...<<......<<<<<...<...<<<....<<<<......>>>>.((......<<<.....))>>>...>>>.....>...>>>>>......<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>...>>.........>>>>>>.>>..............<<....>>....>>..........<<......>>....................>>.>>>>>>........<<<<<...<.........>...>>>>>...<............>.<<<<<<....<<<.<..<<<<<....<<<................>>>...<<....>>...<........>...........>>>>>.>.>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<.....<<<<<......>>>>>......>>>...<<<<.<.<<........>>.>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>..<<<<<.....<.<<.<<<<<<...<<....<<<..<<<....<<.............>>....>>>..>>>...>.>...>>>>>>.>.>.>....>>>>>.....<<<<<<<.<........>.>>>>>>>....<<<......>>>...<<<<.<<<...<<<((......<<<<<............<<...<.<<<<<<.........<<<<.<<...<<<.........>>>...>>.........<<......>>...>>>>.....>>>>>>.>..>>...........)).......>>>>>.>>>...>>>>>>>..<.<<.<<.......>>.>>>.......>>>>>><.<<<<<<..<<.......<<<..<<....>>..>>>....>>.>.>>>>>..>.....>>>>>>.......<<.....<<<<<.........>>>>><<<<....<<<<<.<.<.<<<<<<<...<<.....>>.>>>>>>>...<<.((...<...<<<...<<<....>>>...>>>...>.....<<<..........>>>.>>.<..<<<<....<<...........<<<<.......<<<<..<<<..<....[......>.>>>..<.........<<...<<<<<.............>>>>>......>>.........>.....<..<.....>...>.....>>>>.........>>>>................>>.......>>>>..>.))....>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>...<<<....<<<<<<<..<<...............<<<<<...............>>>>><<<<...........>>>>............<<<<<<<<<..<<...........>>..<<<<<<<.....<<.......>>.......>>>>>>>.<<<<<.<<...<<<<<<<..<<<........<<<.................>>>........>>>>>>>>..>>.>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>.....>>..>>>>>>>.>>>.>>...........<<<<<........>>>>>..<<<<<<<<.<<..<<......<<<<.<<<<<<..<<<<..<<<.<<<<..<<<<...<<<<.<.<...............<<..<<<......<<<<<<......>>>>>>...>>>............>>......>.>.>>>>...>>>>...<<<..............>>>.....>>>>.>>>...>>>>..<<<.......>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<.<<.......>>.>>>.....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.........<<..<<<<<<....<<.......>>....>>>>>>...>>..........<<<<<...<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>.......>>>.>>....<<<<<<<....>>>.>>>>....>>...>>>>>>>>>>....<<<<<<<...<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<...<<<<<<<<<<...]..>>>>>...>>>>>...>>>>.>>>>>....<<....<<<...............>>>....>>..>>>>.......>>>>>>>................<.<<<<<.......>>>>>....<<<<<<.<..<......<<<......>>>.....>...>.>>>.>>>....>........>>>>>>. (..(((..........((((((((.....(((..(((.((((.(((......((((((..[.....))).....((((((..........]...........))))))...))).....((....)).(((........))).(((....))).))...((((.......(...[..)........))).).........((....))...(((.......((.]...))......)))...((......(((((...((..(((...(((((......)))))[[......(((.....]])))...)))....))...))))).......(((((.(.........).))))).......(((((..[[[[)))))...))......)..)))).).))..............((....))....))......(....((....))..............)).....)))))))).........(((((.((...........)).)))))...(............).((((((....(((.((.(((((....((....((......))....))...((....))....((.....))...........))))).)))))..((.(...((((((.....((((((((.(.((((.....((((......)))).....)[)))...(((..(..(........)..).)))....)))))))))...(((.....)))......))))))......).))..(((((.....(((((....))))).((((((.......((.((((((...(((...(((.((((....((.............))....)))).)))..)).)...)))))).).)......))))).)...(((((((.((......)).)))))))....(((......)))...(((...((...((([.[...(.((((((.....(.....((..((...((((.........((((..((..((...........))..))..........(........)...)))).....))))...)).))..........].].)....))))))))))...))..)))...(((.((.......)).)))........)))))(.((((((..((.......(.(..((....))..).)....))..))))))..).....)))))).......((.....((((.(.......).))))((((....((((..((...((((((...((.....)).))))))....(([..[.((...(((...(((....)))...)))...)).....((..........))..))((..((((....(.......(....(((...(.....((....((..((...{.....)).))..(.................(.(.............).)...................).....(...(....)...)......))......)....)))..........)......).......))))..))]..]..)).....((......)).)))).((((......))))..))))..((((....(((((((..((..(....(.......(((((....(....).....)))))(((((.........)))))(...).......(((((((((.].(...........)...(((((((.....(((.....))).......)))))))..((((.((...(((((((..(((........((((...((....))....))))........))))))))..)).))(((.(.........).)))........((..........(((((.......)))))..)..)....))))...)).))))))).)..)))..))))))).))))))...........(((((........)))))..((((((((.((..((......((((.((((((..((((..(((.((((..((((..(((((.((((.(......[..(..((..(((.......((((((....))))))....)))..........].))..)).)))).)))))..))))...(((..............))).....)))).)))...))))..(((......[)))((((((..........]))))))([((...(((((((...((..((.......))..)).....((][.[[[))....)))))))...((((..(.....{....)..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..)))))).......(.((...((((.(...((.......))...).))))....))..)........((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....))...))))))))))....(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((..}.))))))...)))))...)))).))))).....(....((.................))....)...)))).......)))))))................(((((((.......)))))....(((.((((..(.....(((((....)))))....)...))))..)))...))........)))..). Crystal structure of five 70s ribosomes from Escherichia Coli in complex with protein Y.; 23S RIBOSOMAL RNA 4v4g HA 118 11.5 RF00001 URS000080E160_562 15502846 0003735 0005840 562 cccccgugcccauagcacuguggaaccaccccaccccaugccgaacugggucgugaaacacagcagcgccaaugauacucggaccgcagggucccggaaaagucggucagcgcggggg .<<<.<<<<.....<<.<<<<<....<<<<<<...............>>>..>>>...>>>>>..>><<<.......<<.<<<<<....>>>>>.>>.......>>>..>>>>>>>.. ..((..(((.....((.(((((....(((((((...(.....)...))))..)))...)))))..)).((.......(..(((((....)))))..).......))...)))..)).. Crystal structure of five 70s ribosomes from Escherichia Coli in complex with protein Y.; 5S RIBOSOMAL RNA 4v4g IA 1526 11.5 RF00177,RF01959,RF01960 URS000080E307_562 15502846 0003735 0005840 562 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcggauacgcgcggccccuuggggccgugcgucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacgcaaguccaaagggggaagccuucgggucccccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaaccagggccacucauacuggcucugacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucuggcggcucaaccgcugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccuucgggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccggguaaccuacgggaagaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggauca ....<<<<....{[[..>>>>.<<<<.<<<<<..<<<<<<<......<<<.<<<..<<<..<<.....<<<<..<<<<....>>>>..>>>>...>>>>>......<<.......<<<<<<<<..<<...<<...<<....<<....<<<..........>>>.....>>........<<<....>>>......<<<<..........>>>.>..>>...>>..>>>>>>>>>><<<....<<<....<<<<..........>.>>>..>>>......>>>...<<.<<<<....>>>>....>>..>>.<<<<<............>>>>>...<<....>>.....>>>>>>.........<<<....<<<<....>>>>..>>>...>.>>>>>>..<<<<......<<<......>>>.....>>>>..<<<<<<<.........<<<<<<<.......>>>>>>>...........>>>>>.>..>.<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<.(......<<<<...<<<.<<<<<<<.<<<<.<<<<.........<<<<.....>>>>.......>>>>.>>>..>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<....<<<......>>>.......>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<.....>>>>>>>>>>>>...<<...)>>.....>>>>>>..>>.<<<......<<<<....>>>>....>>>...]].}..<<<<.<<<<<<<.<<..<<<<...<<<<<<<<<<......<<........>>..........<<<<<<.......<<<<<.<<...<.<<<<....>>>>.>..............>>.>>>>>.<<..<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<.....<...<<<.....>>>>.......>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>.>>....>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>......>>>>.....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>........<<...<<<<.<<<..<<<<<<<<<.<<....<.<<<<..................>>>>.>...>>.>>>>>>>>>..>>>.>>>>....>>.........<<<<<<<<<....>>>>>>>>>...... ....((((.....[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.....(((((.((((....)))).)))))...)))))......(((.......(((((((..((...(((.(((...(((....(((.(......).))).....)))........((....))........(((..((....)))))....))).)))..))))))))).(((.[..(((..(.((((.(.......)).))).))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.((([..(((((....))))]))))).)).))))))..((((......(((......))).....))))....((.((...(.....(((((((.......)))))))......)....)).))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((.[[...(.((((...(((.(((((((.((((.(((((......(.((((.....)))).)....))))).))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((.........))))))))))...((..]])).....))))))).)).(((....].((((....))))....)))...]].....(((.(((((((.((..(((((..((((((((.(......((........))..........(((((((......(((((........((((....)))).......(....)......)))))..(..(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((.....(....((.....)).).......))))).....(((((....)))))........)))).....).).)))...)).))).)....)))))))..[)..)))))))).(...(((((((.....(.(..((..((((....))))..))....).).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).....(.(..((.(..(((.(((..(((.((((((((....(.((((......(......)....)))).)...)))))))).)))..))).)))...).))...)..)..(((((((((....)))))))))}..... Crystal structure of five 70s ribosomes from Escherichia Coli in complex with protein Y.; 16S ribosomal RNA 4v4g JB 2825 11.5 RF02540,RF02541 URS000080DF1F_562 15502846 0003735 0005840 562 ggucaagauaguaaggguccacgguggaugcccuggcgcuggagccgaugaaggacgcgauuaccugcgaaaagccccgacgagcuggagauacgcuuugacucggggauguccgaauggggaaacccaccucguaagagguauccgcaaggaugggaacucagggaacugaaacaucucaguaccugaaggagaagaaagagaauucgauuccguuaguagcggcgagcgaacccggaucagcccaaauucaaccccucaagccgaaguggcuggaaagcuacaccucagaaggugagaguccuguaggcgaacgagcgguugacuguaaggucguuguucgugaaacgaugacugaauccgcgcggaccaccgcgcaaggcuaaauacucccagugaccgauagcgcauaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaagagaaccugaaaccguggacuuacaagcagucauggcaccuuaugcguguuauggcgugccuauugaagcaugagccggcgacuuagaccugacgugcgagcuuaaguugaaaaacggaggcggagcgaaagcgaguccgaauagggcggcauuaguacgucgggcuagacucgaaaccaggugagcuaagcaugaccagguugaaacccccgugacagggggcggaggaccgaaccggugccugcugaaacagucucggaugaguuguguuuaggagugaaaagcuaaccgaaccuggagauagcuaguucuccccgaaauguauugagguacagccucggauguugaccauguccuguagagcacucacaaggcuaagggcacguaauguguucuaaaccuuaugaaacuccgaaggggcacgcguuuaguccgggagugaggcugcgagagcuaacuuccguagccgagagggaaacaacccagaccaucagcuaaggucccuaaaugaucgcucagugguuaaggaugugucgucgcauagacagccaggagguuggcuuagaagcagccacccuucaaagagugcguaauagcucacuggucgagugacgaugcgccgaaaaugaucggggcucaagugaucuaccgaagcuauggauucaacucgcgaagcgaguugucugguaggggagcguucaguccgcggagaagccauaccggaaggagugguggagccgacugaagugcggaugccggcaugaguaacgauaaaagaagugagaaucuucuucgccguaaggacaaggguuccuggggaagggucguccgcccagggaaagucgggaccuaaggugaggccgaacggcgcagccgauggacagcaggucaagauuccugcaccgaucauguggagugauggagggacgcauuacgcuauccaaugccaagcuauggcuaugcugguugguacgcucaagggcgaucgggucagaaaaucuaccggucacaugccucagacguaucgggagcuuccucggaagcgaaguuggaaacgcgacggugccaagaaaagcuucuaaacguugaaacaugauugcccguaccgcaaaccgacacagguguccgagugucaaugcacuaaggcgcgcgagagaacccucguuaaggaacuuugcaaucucaccccguaacuucggaagaagggguccccacgcuucgcguggggcgcagugaauaggcccaggcgacuguuuaccaaaaucacagcacucugccaacacgaacaguggacguauagggugugacgccugcccggugccggaaggucaaguggagcgguaagugcaagcaaagcugcgaaaugaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaggcguaacgaucugggcgcugucucaacgagggacucggugaaauugaauuggcuguaaagaugcggccuacccguagcaggacgaaaagaccccguggagcuuuacuauagucuggcauucaacguugagacguggugcguaggauaggugggaggcgaagaacccuggcuacggcuggggggagccgccggugaaauaccacccucuacuuuuugacguuguaaccugaaaaaucacuuucggggaccgugcuuggcggguaguuugacuggggcggucgccucccaaaauguaacggaggcgcccaaaggucaccucaagacgguuggaaaucgucuguagagcgcaaagguagaagguggcuugacugcgagacugacacgucgagcagggaggaaacucgggcuuagugaaccggugguaccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagaguccauaucggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgcuacgggcgcaggagaauugaggggaguugcuccuaguacgagaggaccggagugaacggaccgcuggucucccugcugucguaccaacggcacaugcaggguagcuauguccggaacggauaaccgcugaaagcaucuaagcgggaagccagccccaagaugaguucucccacuguucagguaagacucccggaagaccaccggguuaagaggccaggcgugcacgcauagcaauguguucagcggacuggugcucaucagucgaggucuugacca <<<<<<<........<<<<<<.<<......<<..<<<<<<<<..<<......<<<.<<........>>......<<<<<<......................>>>>>>...>>>.....<......>.<<<........>>><<<<....>>>>>>...<<<<.......<......>........>>>.>.........<<....>>...<<<.......<<.....>>......>>>...<<......<<<<<...<...<<<....<<<<......>>>>.((......<<<.....))>>>...>>>.....>...>>>>>......<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>...>>.........>>>>>>.>>..............<<....>>....>>..........<<......>>....................>>.>>>>>>........<<<<<...<.........>...>>>>>...<............>.<<<<<<....<<<.<<.<<<<<....<<<................>>>...<<....>>...<........>...........>>>>>>>.>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<.....<<<<<......>>>>>......>>>...<<<<.<.<<........>>.>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>..<<<<<.<...<.<<.<<<<<<...<<....<<<..<<<....<<.............>>....>>>..>>>...>.>...>>>>>>.>.>.>.>..>>>>>.....<<<<<<<.<........>.>>>>>>>....<<<......>>>...<<<..<<<...<<<((......<<<<<............<<...<..<<<<<.........<<<<.<<...<<<.........>>>...>>.........<<......>>...>>>>.....>>>>>..>..>>...........)).......>>>>>.>>>...>>>.>>>..<.<<.<<.......>>.>>>.......>>>>>><.<<<<<<..<<.......<<<..<<....>>..>>>....>>.>.>>>>>..>.....>>>>>>.......<<.....<<<<<.........>>>>>.<<<....<<<<<.<.<.<<<<<<<...<<.....>>.>>>>>>>...<<.((...<...<<<...<<<....>>>...>>>...>......<<..........>>..>>.<..<<<<....<<...........<<<<.......<<<<..<<<..<....[[.....>.>>>....<.......<<...<<<<<.............>>>>>......>>.......>.......<..<.....>...>.....>>>>.........>>>>................>>.......>>>>..>.))....>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>....<<<....<<<<<<<..<<...............<<<<<...............>>>>><<<<...........>>>>............<<<<<<<<<..<<...........>>..<<<<<<<.....<<.......>>.......>>>>>>>.<<<<<..<...<<<<<<<..<<<........<<<.................>>>........>>>>>>>>..>>.>.<<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>.....>>..>>>>>>>.>>>.>>...........<<<<<........>>>>>..<<<<<<<<.<<..<<......<<<<.<<<<<<..<<<<..<<<.<<<<..<<<<...<<<<.<.<...............<<..<<<......<<<<<<......>>>>>>...>>>............>>......>.>.>>>>...>>>>...<<<..............>>>.....>>>>.>>>...>>>>..<<<.......>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<.<<.......>>.>>>.....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.........<<..<<<<<<....<<.......>>....>>>>>>...>>..........<<<<<...<<<...<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>......>>>.......>>>.>>....<<<<<<<....>>>.>>>>....>>...>>>>>>>>>>....<<<<<<<...<<<<...<<<<<<...............>>>>>>..<<<<....<<<<...<<<<<<<<<<..]]..>>>>>...>>>>>...>>>>..>>>>..........<<<...............>>>........>>>>.......>>>>>>>................<.<<<<<.......>>>>>....<<<<<<.<..<......<<<......>>>.....>...>.>>>.>>>....>.......>>>>>>>. ((((((((........((((((((.....(((..(((.((((.((.......((((((..[.....))).....((((((..........]...........))))))...))).....((....)).(((........))).(((....)))..)...((((.......(...[..)........))).).........((....))...(((.......((.]...))......)))...((......(((((...((..(((...(((((......)))))[[......(((.....]])))...)))....))...))))).......(((((.(.........).))))).......(((((..[[[[)))))...))......)..)))).).))..............((....))....))......(....((....))..............)).....)))))))).........(((((.((...........)).)))))...(............).((((((....(((.(.((((((....((....((......))....))...((....))....((.....))...........))))).)))))..((.(...((((((.....((((((((.(.((((.....((((......)))).....)[)))...(((..(..(........)..).)))....)))))))))...(((.....)))......))))))......).))..(((((.....(((((....))))).(((((((......((.((((((...(((...(((.((((....((.............))....)))).)))..)).)...)))))).).).....)))))).)...(((((((.((......)).)))))))....(((......)))....((..(((...((([.[...(.((((((.....(.....((..(((..((((.........((((..((..((...........))..))..........(........)...)))).....))))..))).))..........].].)....))))))))))...))).))....(((.((.......)).)))........)))))(.((((((..((.......(.(..((....))..).)....))..))))))..).....)))))).......((.....((((.(.......).))))((((....((((..((...((((((...((.....)).))))))......(..(.((...(((...(((....)))...)))...))....(((..........)))...((..((((....(......(.....(((...(....(((....((..((...{.....)).))....................(.(.............).).........................(...(....)...)......))).....)....)))..........)......).......))))..)))..)..)).....((......)).)))).((((......))))..))))..((((....(((((((..((..(....(.......(((((....(....).....)))))(((((.........)))))(...).......(((((((((.].(...........)...(((((((.....(((.....))).......)))))))..((((..(...(((((((..(((........((((...((....))....))))........))))))))..)).).(((.(.........).)))........((..........(((((.......)))))..)..)....))))...)).))))))).)..)))..))))))).))))))...........(((((........)))))..((((((((.((..((......((((.((((((..((((..(((.((((..((((..(((((.((((.(......[..(..((..(((.......((((((....))))))....)))..........].))..)).)))).)))))..))))...(((..............))).....)))).)))...))))..(((......[)))((((((..........])))))).[((...(((((((...((..((.......))..)).....((][.[[[))....)))))))...((((..(.....{....)..)))).(((....))).))]]].].....(((((((.((..]]]]..)))))))))......}......))))..)))))).......(.((...((((.(...((.......))...).))))....))..)........((((.((..(...(((((((((......))))))..))).(((((.....)))))......)..)..)...))).).....(((((((....))).))))....))...))))))))))....(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((..}.))))))...)))))...)))).))))).....(....((.................))....)...)))).......)))))))................(((((((.......)))))....(((.((((..(.....(((((....)))))....)...))))..)))...))......)))))))). Crystal structure of five 70s ribosomes from Escherichia Coli in complex with protein Y.; 23S RIBOSOMAL RNA 4v4g JA 118 11.5 RF00001 URS000080E160_562 15502846 0003735 0005840 562 cccccgugcccauagcacuguggaaccaccccaccccaugccgaacugggucgugaaacacagcagcgccaaugauacucggaccgcagggucccggaaaagucggucagcgcggggg .<<<..<<<.....<<.<<<<<....<<<<<<...............>>>..>>>...>>>>>..>><<<.......<<.<<<<<....>>>>>.>>.......>>>..>>>.>>>.. ..((..(((.....((.(((((....(((((((...(.....)...))))..)))...)))))..)).((.......(..(((((....)))))..).......))...)))..)).. Crystal structure of five 70s ribosomes from Escherichia Coli in complex with protein Y.; 5S RIBOSOMAL RNA 4v4h AA 1530 3.46 RF00177,RF01959,RF01960 URS00000ABFE9_562 16998486 0003735 0005840 562 ugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggauca ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<<<..>>>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<.<.......>>>.>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<.<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>..>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((((((((..)))))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(...(((((((.(.......))).)))).)...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))...((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.....]...)))))))......))...)))))))))).))..(.(..((.(..(((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).)))...).))...)..)..(((((((((....)))))))))}..... Crystal structure of the bacterial ribosome from Escherichia coli in complex with the antibiotic kasugamyin at 3.5A resolution.; 16S RIBOSOMAL RNA 4v4h BA 117 3.46 RF00001 URS0000049E57_562 16998486 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggc <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>> (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))) Crystal structure of the bacterial ribosome from Escherichia coli in complex with the antibiotic kasugamyin at 3.5A resolution.; 5S RIBOSOMAL RNA 4v4h BB 2841 3.46 RF02540,RF02541 URS00004B0F34_562 16998486 0003735 0005840 562 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<<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.<...<<<...<<<.<<<<.......>>>>.>>>..>>.>...>.>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.......<<<<<..<<....>>...>>>>>.......>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<.....<<<<<<<<....>>>>>>>>....>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>.(<<...<<<<<<<...<<<<<<.......>>>>>>.....<<)..(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<<...>>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((...(((((((((.(...(((...(((.((((.......)))).)))..)).)...).)))))).)))...))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((..((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((.....{{{....)))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((((.(...((((((((....))))))))..).)))).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((...))))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Crystal structure of the bacterial ribosome from Escherichia coli in complex with the antibiotic kasugamyin at 3.5A resolution.; 23S RIBOSOMAL RNA 4v4h CA 1530 3.46 RF00177,RF01959,RF01960 URS00000ABFE9_562 16998486 0003735 0005840 562 ugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggauca ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<<....>>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<.<.......>>>.>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((((((((..)))))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(...(((((((.(.......))).)))).)...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((..(((((((....)))))))...((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.....]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Crystal structure of the bacterial ribosome from Escherichia coli in complex with the antibiotic kasugamyin at 3.5A resolution.; 16S RIBOSOMAL RNA 4v4h DA 117 3.46 RF00001 URS0000049E57_562 16998486 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggc <<<<<<<<<.....<<<<<<<<.....<<<<<<.............>>>>..>>....>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>> (((((((((.....((((((((.....((((((...(.....)...))))..))....)))))).)).((.......((((((((...)))))))).......))...))))))))) Crystal structure of the bacterial ribosome from Escherichia coli in complex with the antibiotic kasugamyin at 3.5A resolution.; 5S RIBOSOMAL RNA 4v4h DB 2841 3.46 RF02540,RF02541 URS00004B0F34_562 16998486 0003735 0005840 562 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((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((...(((((((((.(...(((...(((.((((.......)))).)))..)).)...).)))))).)))...))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((..((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((.....{{{....)))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((((.(...(((((((......)))))))..).)))).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((...))))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Crystal structure of the bacterial ribosome from Escherichia coli in complex with the antibiotic kasugamyin at 3.5A resolution.; 23S RIBOSOMAL RNA 4v4i w 2889 3.71 RF02540,RF02541,RF00002 URS000080E04D_262724 16962654 0003735 0005840 262724 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<<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<........<<<<<<.[.[.((.>>>.....<<<<<<<..<<<)).].].>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.....>>>>>>......<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<.....<<<<<<<.....>>>>>>.>......<<<<<<<<.....<<<...<<<<<.<<<..<<<....<<<<......>>>>.<<......((......>>.))...>>>....>>>.>>>>>...>>>.>>>>>.>>>.....<<<...<<.........>>...>>>......<<<<<..<<<<>>>>>..>>>......>>.>>>>>>.>>...............<......>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>..................<<<<<<....<<<..<<<<<<<<..<<<...<<.......>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>..>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>...>>>..<<<<<<....<<<<<....>>>>><.<<<<<<<.....<<<<<<<<<...<<<...<<<<.<<<.<.<<<<<<......>>>>.>>>..>>>.>>>>..>>.>...>>>>>>>>>.....>>>>>>>..>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<((......<<<<<<...........<<..<<.<<<<<.........<<<<<.<<...<<<<.......>>>>...>>.......<.<<......>>.>.>>>>>.....>>>>>.>>.>>...........))......>>>>>>.>>>...>>>>>>><<<<<.<<.....>>.>>>>>....>>>>>>.<<<<<<...<<.......<<<<<.<<<....>>>>>>>>....>>..>>>>>.>......>>>>>>.......<.......<<<<<.......>>>>>.<<<<....<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<....<<<....<<<<<.<<<..<<<<<.<<<<.<<..((((...>>>>>><<<...<<<<<<<<<<<<<<<<.<.......>>>>>>>>....>>>>>>>>>..>>>...<.<<......>>>......>>>>>...>>>..>>>>>.........>>>....>>...>>>>>>>>>>>>>>>..>>.....<<......>>.>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<<.<<<<.....>>>>.>>>>>>>............<<<<<<<<<...<<.........>>...<<<<<<<.....<<<....>>>.......>>>>>>>..<<<<.<<<.....<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>.....>>><<<<<.........>>>>>....................<<<<<.......>>>>>..........>>>>...>>.>>>>>>>.....>>.>>>>>>>>.>>>>.>...........<<<<<........>>>>>..<<<<<<<<.<<..<<......<<<<.<<<<<<..<<.<..<<<.<<<<<.<<<<...<<<<<<<<<...........<<<<<..<<<<.....<<<<<<<<....>>>>>>>>..>>>>............>>>>>..>>>>>>>>>...>>>>...<<<<<....>>>>>....>>>>>.>>>...>.>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<....<<<<<<.......>>>>>>.....<<...(((>>.....>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..>>>>..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....>>...>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))))>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<.............>>>>....>>>.>>>>.......>>>>>>>...<<<.....>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>>> 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Crystal Structure of a 70S Ribosome-tRNA Complex Reveals Functional Interactions and Rearrangements.; 23S LARGE SUBUNIT RIBOSOMAL RNA 4v4i x 120 3.71 RF00001 URS000039883D_262724 16962654 0003735 0005840 262724 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>><<<........<<<<<<<....>>>>>>>........>>>.>>>>>>>>>>> (((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((..(....((((((((....))))))))....)..))).))))))))))) Crystal Structure of a 70S Ribosome-tRNA Complex Reveals Functional Interactions and Rearrangements.; 5S LARGE SUBUNIT RIBOSOMAL RNA 4v4i y 1502 3.71 RF00177,RF01959,RF01960 URS000080E229_262724 16962654 0003735 0005840 262724 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgaggaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcug ....<<<<...[[(((.>>>>.<<<<.<<<<<..<<<<<<<......<<<.<<<..<<<..<<.<<<<<<<<<<.....>>>>>>>>>>.>>>>>......<<.......<<<<<<<<.......<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>....>>>>>>>><<<....<<...<<<<<<<<.......>>>>>>>>.>>......>>>..<<<<.<<<....>>>....>>>>.>>.<<<<<............>>>>>.<<<<....>>>>...>>>>>>......<<.<<<....<<<<....>>>>..>>>>>.>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>>..>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<....<<<......>>>.......>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<.<.<<<<...>>>>.>.>>>...<<..))>>.....>>>>>>.>>>.<<<.......<<<....>>>.....>>>..))).]]<<<<<.<<<<<<<..<.<<<<<...<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<<....>>>>..>>>>>>>>.<<<.<<...<<<<<<.<.....<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<...<<...<<<.....>>>.>>....>>>>>>.....<<<<......>>>>........>>>>.....>...>>>...>>>.>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>..........<.<<<<<<........>>>>>>>...........>>>>>.....<<<<<<..........>>>>>>.......>....>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>. ....((((..[.[[[[.)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.....)))))))))).)))))......(((......(((.((((..((...(((((((.(((((....((((.(....).)))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..)))))).)))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).)....((.(((...(((((....)))).)))))))).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((...(((((((....((........)).......)))))))...).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))..]]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((((..(((((((....)))))))...((((....))))..))))))))).((.(((...((.(((.(....(((((((((....)))..((((......))))..)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).))....)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((..........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))} Crystal Structure of a 70S Ribosome-tRNA Complex Reveals Functional Interactions and Rearrangements.; 16S SMALL SUBUNIT RIBOSOMAL RNA 4v4i z 76 3.71 RF00005 URS00005AA258_562 16962654 0030533 0006412 562 gcccgganagcucagncggnagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((.........)))).....(((((..]....)))))))))))).... Crystal Structure of a 70S Ribosome-tRNA Complex Reveals Functional Interactions and Rearrangements.; P-site PHE-tRNA 4v4i 0 76 3.71 RF00005 URS000080E050_262724 16962654 0030533 0006412 262724 gcggauuuagcucaguugggagagcgccagacugaaaaucuggagguccuguguucgauccacagaauucgcacca <<<<<<...<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>.>>>>>>.... (((((((..((((.....[..)))).(((((.......))))).....(((((..]....)))))))))))).... Crystal Structure of a 70S Ribosome-tRNA Complex Reveals Functional Interactions and Rearrangements.; E-TRNA 4v4j w 2889 3.83 RF02540,RF02541,RF00002 URS000080E04D_262724 17940016 0003735 0005840 262724 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((((((((......((((((((((.....(((..((((((((((((......((((((.[[.[[[.))).....((((((...(((]]].]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...((((((((.....))))))))....{.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))..).))).)))))...))))))))).))))....((((((((..[......))))))))....}.(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((.(.((((((......)))).)).).))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((..((((.......))))..))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(((((((...(((......(((((.(((....))))))))...)))..))))).)).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.((..{{{....))))))(((...((((((((((((((((.((.....)))))))))....)))))))))..)))((...(((....)))...)..))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((.(......).(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((((((((((((((.(......[..(((((..(((......((((((((....))))))))...)))..........].)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}}))))))...))))).<.)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..((((.....))))....(((((((((.......)))))....((((((((.(((....(((((....)))))...))).>))))).)))...))))....)))))))) Interactions and Dynamics of the Shine-Dalgarno Helix in the 70S Ribosome.; 23S LARGE SUBUNIT RIBOSOMAL RNA 4v4j x 120 3.83 RF00001 URS000080DFF2_262724 17940016 0003735 0005840 262724 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>..>>>>>>>>>> (((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).)).((..(....((((((((....))))))))....)..))..))))))))))) Interactions and Dynamics of the Shine-Dalgarno Helix in the 70S Ribosome.; 5S LARGE SUBUNIT RIBOSOMAL RNA 4v4j y 1514 3.83 RF00177,RF01959,RF01960 URS000080E229_262724 17940016 0003735 0005840 262724 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgaggaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngccngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggnnggugcggcuggaucaccuccuu ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<......<<<.<<<..<<<..<<..<<<<<<<<<.....>>>>>>>>>..>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>....<<<<.<<<<<....>>>>>.>>>>...<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>......<<.<<<....<<<<....>>>>..>>>>>.>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>>..>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<....<<<......>>>.......>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<<....>>>>..>>>>>>>>.<<<.<<....<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>..>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<..<<.<<<<<<........>>>>>>>>...>.....>>>>>>.....<<<<<<..........>>>>>>.......>....>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>............. ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.....)))))))))).)))))......(((......(((.((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..)))))).)))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).)....((.(((...(((((....)))).)))))))).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((...(((((((....((........)).......)))))))...).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((((..(((((((....)))))))...((((....))))..))))))))).((.(((...((.(((.(....(((((((((....)))..((((......))))..)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).))....)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((..........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}............ Interactions and Dynamics of the Shine-Dalgarno Helix in the 70S Ribosome.; 16S RNA 4v4j z 77 3.83 RF00005 URS00001BBAFC_262724 17940016 0030533 0006412 262724 cgcgggguggagcagccugguagcucgucgggcucauaacccgaagaucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(.(((..]....))).)))))))..... Interactions and Dynamics of the Shine-Dalgarno Helix in the 70S Ribosome.; P-site tRNAfMET 4v4j 2 76 3.83 RF00005 URS000080E050_262724 17940016 0030533 0006412 262724 gcggauuuagcucaguugggagagcgccagacugaaaaucuggagguccuguguucgauccacagaauucgcacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).(((((.......))))).....(((((..]....)))))))))))).... Interactions and Dynamics of the Shine-Dalgarno Helix in the 70S Ribosome.; E-site tRNA 4v4j 3 18 3.83 17940016 262724 aaggagguaaaaaugacc .................. .................. Interactions and Dynamics of the Shine-Dalgarno Helix in the 70S Ribosome.; MRNA 4v4n B1 77 9.0 RF00005 URS00001D39A7_2190 24153188 0030533 0006412 2190 ggggcgguagcucagccugggagagcaccggacugaagauccgggugucggggguucaaaucccccccgccccacca <<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.........)))).(((((.......))))).....(((((.......)))))))))))).... Structure of the Methanococcus jannaschii ribosome-SecYEBeta channel complex; E-tRNA 4v4n B2 1495 9.0 RF00177,RF01959,RF01960 URS000012A2B3_2190 24153188 0003735 0005840 2190 auuccgguugauccugccggaggccacugcuauggggguccgacuaagccaugcgagucaagggggcgucccuucugggacgccaccggcggacggcucaguaacacgucgguaaccuacccucgggagggggauaaccccgggaaacuggggcuaaucccccauaggccugggguacuggaagguccccaggccgaaagggagccguaaggcccgcccgaggaugcggcggcggccgauuagguaguuggugggguaacggcccaccaagccgaagaucgguacgggccgugagagcgggagcccggagauggacacugagacacggguccaggcccuacggggcgcagcaggcgcgaaaccuccgcaaugcgggaaaccgcgacggggggacccccagugccgugccucuggcacggcuuuuccggaguguaaaaagcuccgggaauaagggcugggcaaggccgguggcagccgccgcgguaauaccggcggcccgagugguggccacuauuauugggccuaaagcggccguagccgggcccguaagucccuggcgaaaucccacggcucaaccguggggcucgcuggggauacugcgggccuugggaccgggagaggccggggguacccccgggguaggggugaaauccuauaaucccggggggaccgccaguggcgaaggcgcccggcuggaacggguccgacggugagcgcggaaggccaggggagcgaaccggauuagauacccggguaguccuggcuguaaaggaugcgggcuaggugucgggcgagcuucgagcucgcccggugccguagggaagccguuaagcccgccgccuggggaguacggccgcaaggcugaaacuuaaaggaauuggcgggggagcacuacaagggguggagcgugcgguuuaauuggauucaacgccgggaaccucaccgggggcgacggcaggaugaaggccaggcugaaggucuugccggacgcgccgagaggaggugcauggccgccgucagcucguaccgugaggcguccacuuaagugugguaacgagcgagacccgcgcccccaguugccagucccucccgcucgggaggaggcacucuggggggacugccggcgauaagccggaggaaggggcgggcgacgguaggucaguaugccccgaaacccccgggcuacacgcgcgcuacaaugggcgggacaaugggacccgaccucgaaaggggaagggaauccccuaaacccgcccucaguucggaucgcgggcugcaacucgcccgcgugaagcuggaaucccuaguacccgcgugucaucaucgcgcggcgaauacgucccugcuccuugcacacaccgcccgucacuccacccgagcggaguccgggugaggccugaucuccuucgggaggucaggucgagcccgggcuccgugaggggggagaagucguaacaagguaaccguaggggaaccuacggcucgaucaccuccu ...<<<<<.[.((((>>>>>.<<<<<<<<<....<<<<.<<......<<<.<<<..<<<..<<.<<<<<<<<....>>>>>>>>.>>>>>......<<........<<<<<.....<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<<<<<.<<<....>>>>>>>>>>>>....<<..<<<....>>>>>.>>>>>>>..>...>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<............>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>..>>>>...<<<<<<<<...>>>>>>>>...<<<<<<<<.......>>>>>>>>.....<<<<<((.....<<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((......<<....<<<.<<<<<<<.<<<<<<<<<.....<<<<<<<<.....>>>>>>>>....>>>>>>>..>>>>>>>>>...<<<<<<.....<<<<<<<.<..<<<<<<<<<..<<<......>>>.....>>>>>>>>>..>........<<....>>.>>>>>>>....>>>.>>>...>>>....>>....<<<<<<<...<<...<<<<.........>>>>...>>>>>>>>>.........<<<<<<..<<<<<<<<<<<<<<.....>>>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<.<<<<<<..<<<<<<<<<.......<<........>>..........<<<<<<<...<<<<........<<<.<<<.......>>>.>>>......>>>>...<<.<<<..<<<<<<<<<....<<<<<<.<<....>>...<<<<......>>>>..>>>>>>....<<<<<.<<<<<<<.........<<<<<<....>>>>>>.......>>>>>>>.....<<<<<.....>>>>>........>>>>>....>>>.>>>...>>>>>>>>....>>>>>>>....>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<......>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>.....<<<<<<.........>>>>>>.......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<..<<<<<<<<<<<<....>>>>>>>>>>>>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<.<<<<<<<....>>>>>>>.>............ ...(((...[.[[[...))).((((((..(....((((.(((.....(((.(((..(((..(..((((((((....))))))))..))))......(((.......(((((.(...(...(((((((.(((((....(((.((....)).))).....)))))...(((((((((.((......)))))))))))....((..(((....))))).)))))))..).).))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).))..))))...((((.(((...))).))))....((((((.........))))))......((((.[[.....(((((.....((..]])).......))))).))))..)..))))))..........((([[...(..((....(((.(((((((.((((((..(......(((((((.....))))))).....)..))))..)))))))))..(((((((.....((((((.((..((((((((...((........))......))))))))..)).......((....))..))))))....))).)))..))))....)).....((((((...((...((((.........))))...))))))))......{...((((((..(((.((((((((((.....)))))))))).)))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((..((.((((((..((((((((((......((........))..........(((((((...((((.(......(((.((((.....)))).)))...)..))))...((.(((...(.(((.((....((((((.((....))....(((......)))...))))))....(((((.(((((((.........((((((....)))))).......)))))))..(..(((((.....))))).....)..)))))....))..)))....).)))))....)))))))...)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))))......((((.(.......).))))........))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((..(.(((((.((((....)))).))))).)..)))))))))))))..))).))))..).))...)..)..(.(((((((....))))))).)}........... Structure of the Methanococcus jannaschii ribosome-SecYEBeta channel complex; 16S ribosomal RNA 4v4n A1 2969 9.0 RF02540,RF00002 URS00005F73E8_2190 24153188 0003735 0005840 2190 ggacgcuaagccgcccgguggauggcucggcucggggcgccgacgaagggcguggcaagcugcgauaagccccggcgaggcgcaggcagccgucgaaccggggauucccgaaugggaccucccgcggcuuaugccgcacuccgagggggaacgcggggaauugaaacaucuuaguacccgcaggaaaagaaagcaaaagcgaugccgugaguaggggcgaccgaaaacggcagagggcaaacugaaccccgggccgacgagguucgggggaugugggguuguagggcccccguaugagacccucgcgggugaagccgaaguccgcuggaacgcggcgccggagagggugauagccccguaggcguaagcccgcagggucucgggggacccugaguaccgucgguuggauauccggcgggaagcugggaggcaucggcucccaacccuaaauacgucccgagaccgauagcgaacuaguaccgugagggaaagcugaaaagcaccccgggaggggggugaaaagagccugaaaccgggcggcgauaggagggugcggcccgaaaggaaugagccuccccgaaggaaaccgcggcgacgcgggaguacgaggggaggggaccgggguugcaccguccgucuugaaacacggggcagggaguucgcggccguggcgagguuaaggggguuaagccccguagccgcagggaaaccgacaugcccgcagccgggccggugaggggcggggugcgaaagcgcccggagucacggccgcgagacccgaaaccggucgaucuagcccggggcagggugaagucccucaaccgagggauggaggcccgcuaggggugcugaugugcaguucgcucccgugaccccgggcuaggggugaaaggccaaucgaggccggagauagcugguucccgccgaaucaucccgcaggauggccuccccggagguaggcggugggguagagcacugauuggaggugcagggggcgaaagcccccggccuccugucaaacuccgaacccaccgccgccguagauggggggaguaggguggcgguguaagccguccaccgagaggggaacaacccagaccgggguuaaggccccaaagugccggcuaaguguuacuccaaagggugucccgggccuuagacagcggggagguaggcuuagaagcagccauccuuuaaagagugcguaacagcucacccgucgagguccggggccccgaaaauggacggggcucaagccggccgccgagaccccggcgcacggagugaucggguaggcgggcgugccgguggcguagaagccgggccguaagguccgguggagccgccgguaucgcggauccugccgggaguagcagcguagucgggugagaaucccgaccgccggaggggccaggguuccacggcaauggucgucagccguggguuagucgguccuaaccccgcccguaacucggcgcgggggaaagggaaacggguuuauauucccguaccgcggggguaggugcggcaacgcaagcccggagggugacgccucgggguaggcggaccggccgaugaggccggcuaagcguauaagcccggggagugccguaauggcgagaaccgggugaaagcgcgaauggcccccccguuagggggguuccgccgaucccuggggcccgugaaaagcccuccgggaauuccgaucccccgcgaccguaccgagaaccgacacaggugccccugggugagaagccuaaggcgugucgggggaaacccggccgagggaacucggcaaacuggccccguaacuucgggagaaggggugccugcgggugcguaacccgcaggucgcagugacuaggggggcccgacuguuuaauaaaaacacaggucccagcuagcccgaaaggguuuguacuggggccgacgccugcccagugccgguaugugaagcccggguacaaccgggugaagcaccgguaaacggcggggguaacuauaacccucuuaagguagcgaaauuccuugucgguuaaaugccgaccugcaugaauggcguaacgagguccccgcuguccccggccggggcccggcgaaaccucugccuggcgcgcaugccagggacccccggugggaagcgaagaccccauggagcuuuacugcagccugccguugccacacggcggggggugcgcagcguaggcgggaggcgucgaagcccggccuccgggucggguggagccguccaugagacaccgcccacuccccgcuguguggcuaacccccgaaaggggggacagcgguaggugggcaguuuggcuggggcggcacgccuccgaaaagguaucggaggcgcccuaaggucggcucaggcgggucaggaauccgccguagagugcaagggcaaaagccggccugacuggacccguaacagaggcggguccagccccgaaaggguggccuagcgaaccccugugccuccccggugggggccagggaugacagaaaagcuacccuggggauaacagagucgucucgggcgagagcccauaucgaccccgaggcuugcuaccucgcugucggcucuucccauccuggcccugcagcaggggccaaggguggggguguucacccauuaaaggggaacgugagcuggguuuagaccgucgugagacaggucggaugcuaucuaccggggguguuggccgccugaggggaaggugccccuaguacgagaggaacagggugccgcggccucuggucuaccgguuguccucccgggcaucgccgggcagcuacgccgcagccgauaaggccugaaagcaucuaaggccgaagcggcccccgaaaauaggcggccguggacgagggcucggguagaagacccgguugauagggcggggauguaagcgggaagggucaaccgacccgcuuaguccgccgccccuaaucgcccgagguccugc 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((.......(((((((((.....(((..((((((((...((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....((.....)).((((......)))).((...)).))...((((((.....(...[..)......))))).)...(.....((....))....(((......((.]...)).....)))....((((...((..((((((..((.....))..)))))....)))..........(((.((......(((((.(((((....(((...({((((......)))))[[......(((....}]])))...))).....))))))))))..)))))......)....(((.(((........))).)))......(((((.[[[[[[)))))..)))....)....)))))).))...............((....))....))......(..((((.....))))..........)).....)))))))))........((((((((((....((......(((((((...(....(((((....))))).....)..)))))))...)).)))))))))).{((((........))))((((((....(((((((((((((..(((....(((.......)))...)))...((....)).....((((...(((((.)))))...)))).((((((....))))))...)))))))))))))..((.(...((((.(.....(((((((((..((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))....))))))))).(.(((.....)))...)..).))))......).))..((((((....(((((....)))))..((((((...(((.(((((((((...(((............(.(...(.((.......)).)..))..........)).)...))))))))))))......))))))....((..((((((....))))))..))....(((......)))...(((((((...((([[[...(.((((((.....(..........(((.(((((((.(........(.....(((..(((.........)))..))).....(...(........).).....)....).))))))))))..........]]].)....))))))))))...)))))))(((((...)))..))....))))))(.((((((((((......((((((((....))))))))...))))))))))..).....))))))((.....((......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...(((((((((.....))).))))))....))...(((((........)))))]]((((((((....((((....)))...(...((((((...(((.(((((.....((.((((((.....))))))....((((.....(((((.....(((.....))).....))))).....)))).....(.((((((....)))))).).).)....))))).)))(...)....))))))...))........)))))))).))).))).....((...[..)).))))..(((.......)))..))))]..((((.....((((((((.((..(............(((((....(.{..).....)))))((((((((((.....))))))))))(...).......((((.((((.].((.........))...((.((((.....(((....))).......)))).)).}.(((.(((..(((((((..(((....(((((......)))))....))))))))..)))))(((((.........)))))........(...........(((((.......))))).....)....)))....)).)).))))....))).)))))))).))))))....)).[..(((((.....}.])))))..((((((((..((.((......((((.((((((..((.((.((((((((..((((((((((((((((((.........(((((..(((.......(((.(((....))).)))....)))............)))))))))))))))))))))))...(((((....))))).....))))))))..)).))..(((......[)).)((((((..........])))))).[((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))..........))))..)))))).......(.((.(.((((((...((.......))...))))))...)))..).......(((((.((((((..(((((((((......))))))..))).((((.......))).)....)))))..)...))).))....(((((((....))).))))....))..)).))))))))....(((((((...((((..(((.(((......(....).....))).)))(((((...((((...((((((((((....)))))..))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))))........(((..((((.......)))).....(((.((((((((....(((((..((.....))..)))))...))))]))))..)))....))).....))... Structure of the Methanococcus jannaschii ribosome-SecYEBeta channel complex; 23S ribosomal RNA 4v4n A3 126 9.0 RF00001 URS000000EE76_2190 24153188 0003735 0005840 2190 cggcggccauagcgggggggccacacccggucucauuucgaacccggaaguuaagccccccagcgaucccgguuguacugcccuccgagagggggcgggaagccggggacgccgccggccacuauc .<<<<<.....<<<<<<<......<<<<<<.............>>>>..>>.....>>>>>.>>..<<<<<<<....<<<<<<.<<....>>>>>>>>...>>>>>>>...>>>>>.......... .((((((....((((((((.......((((...(.....)...))))........)))))).))..(((((((....((((((.((....))))))))...)))))))..)))))).......... Structure of the Methanococcus jannaschii ribosome-SecYEBeta channel complex; 5S ribosomal RNA 4v4p AB 123 5.5 RF00001 URS00001170B4_300852 15802605 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcgggggau ..<<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>>>. ..(((((((..(.....((((((((....(((((((.............))))..)))...)))))).)).((.......((((((((....)))))))).......))...)..))))))). Crystal structure of 70S ribosome with thrS operator and tRNAs.; 5S ribosomal RNA 4v4p AA 2872 5.5 RF02540,RF02541,RF00002 URS000080E08B_300852 15802605 0003735 0005840 300852 ggucaagaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaugcggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgaggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccggguggggggccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucuugacc <<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<..........>>>>>..<.<........>..>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<.....<<<<<<<.....>>>>>>>.......<<<<<<<............<<.<.......<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>.........>>>.........>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<...<.....<......>.....>.....<<....>>...<<......>>.......>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<..<<<...<<<((......<<<<<<<..........<<..<<<<<<..<........<<<<..<<...<<<.........>>>...>>.........<........>....>>>>....>..>>>>>>.>>...........))......>>>>>>>.>>>...>>>.>>><<<<<<<.......>>>>>>>....>>>>>><<<<<<.....<.......<<<<<.<......>.>>>>>....>....>>>>.>>.....>>>>>>.......<......<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<.<...<<<.....<<<<<.<<...<<<<<.<<<<.<<...[[[...>>>>>><.....<<...<<.<<<<<<<...<......>.>>>>>>....>.>>..>>.....>.......................>>>>>....>>..>>>>>.........>>>....>....>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<........>>>.>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>...........<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<..<<<<<<<<<<<<<<<<...........<<<...............<<..<<...>>...>>.....>>>..>>>>>>>>>>>>>>>>...<<<<......>>>>.....>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<..<<<<<<<...<<.......>>...>>>>>>>...>>>.>.......<.<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>..>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]].>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<.<.....>>......<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>>> ((((((((........(((((((((....(((..((((((((((...(....((((((.[......))).....((((((...(((.....].)))......))))))...)))...)(((....)))(((((..........))))).......................((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...(((.....((((.((.....)).)))).......(((..(.............(.(((......(((...(((((......)))))[[(...).(((.....]])))...)))........)).)).........)...))).....(((((((((.......)))))))))......(((((..[[[[)))))..)))......)).)))))).))...............((....))....)).........((((....)))).............)....))))))))).........(((((((((((....)))))))))))...(............).((((((....(((((((((((((............................((....))...(((.....)))......)))))))))))))...(.(...((((((...((((((((((((.((((....(((((......)))))....).)))...(((..((((........)))).)))..).)))))))))))..(.......).......))))))......).)...((((((....((.((....)).))..(((((((.(.(.(((((((((...(((...((((((((...((((((......)))).))...))))))))..)).)...))))))))).).).)))))))......((((((.((......)).)))))).....................((...(((...((([[......(((((((..........((..((((((.(((.......((.((.(((..(.(.........).)..))).........((......))...)).))...))).)))))).))...........]]......))))))).)))...)))..))((((((((.....))))))))....))))))(.((((....(((.......((((.(......).))))....)))...))))..).....)))))).......((.....((((((.......))))))((((....((((..((...((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((.......((....((((..((...(((((.((((.((....{....))))))(.....((...(...((((((............))))))........).))......)......................)))))....))...)))).........))..........)))))))))))))))..)).....((......)).))))..(((......)))...))))..((((....((((((((.((..(....(........((((....(....).....)))).(((((((..((.......))..)))))))............(((((((((...((.........))...((...((.....(((.(.)))).......))...))..((((.(((..(((((((..((....((...(((((....)))))...))....)))))))..)))))(.((((.......)))).)........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).))))))........[..(((((......].)))))..((((((((.(((..(......((((.((((((..(((((.(((.((.(..(((((..(((((((.(.(.........(((..............((.(.((....)).).)..)..)))).).)))))))..)))))...(((((....))))).....).)).)))..)))))..(((.......)))((((((...........))))))([((...((((((..(.(((((.........)))))...).((][.[..)).....))))))...((((..(((......)))..)))).(((....))).))..].].....(((((((.((..]]]]..))))))))).....).......))))..))))))......(((((.(.((((.(...((.......))...).))))...)))).).)........(..((((((..(((((((((......)))))))..)).(((((.....))))).....)))))..)....)........(((((((....))).))))....)...)))))))))))....(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((..((..}.))..))...)))))...)))).)))))...(((....((((.............))))....))).)))).......)))))))....((.....))......(((((((((.......)))))....((((((((.(((.....((((....))))....)))..))))).)))...))))....)))))))) Crystal structure of 70S ribosome with thrS operator and tRNAs.; 23S ribosomal RNA 4v4p BA 1515 5.5 RF00177,RF01959,RF01960 URS000080E226_300852 15802605 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucaccuccuuu ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<...<..<<<.<<<..<<<..<<.<<<<<<<<<.......>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>...>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<(......<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<....<<<......>>>.......>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<...)>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<.......<<<<<<....<<<<<<....>>>>>>....<<<<....>>>>...>>>>>>..<<<.<<<..<<<<<<.......<<<<<.<<<....>>>..<<<<......>>>>...>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<..<.<<<<<<<........>>>>>>>>...>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>.............. ....((((....[[[..)))).((((.(((((..((((((.((....(((.(((..(((..((.(.((((((.........)))))).).)))))......(((......((((((((..((...(((((((.(((((....((((.(....).)))).....)))))....((((.(.(((....))).).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(.(((....)))..))))).)..))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([.[...(((((.....((.].])).......))))))))))..)))))))))..........(((.....(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((....)).....)))))))))).(((......((((....))))....)))...]]]..(((((.(((((((.((..(((((..((((.(((((......((........))..........((((.((..(...((((((((....(((((....)))))...(.((((....)))).)))))))))).((.(((...((((((.((...(((((((((....)))...(((......)))...)))))).....((((.(((((((..(....(((.....)))..)...))))))).....(((((....)))))........))))....)).).)))...)).)))))....)).))))..[)).))).)))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))....(..((.(.((((.(((...((((((((((((...(.((((....(((....))).)))).)..))))))))))))...))).))))..).))...).....(((((((((....)))))))))}............. Crystal structure of 70S ribosome with thrS operator and tRNAs.; 16S rRNA 4v4p BB 76 5.5 RF00005 URS000011107D_300852 15802605 0030533 0006412 300852 gcggauuuagcucaguugggagagcgccagacugaagaucuggagguccuguguucgauccacagaauucgcacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((.(((...(((........)))..((.((.......)).)).....(((((.......)))))))).))).... Crystal structure of 70S ribosome with thrS operator and tRNAs.; tRNA Phe (unmodified bases) 4v4p BC 76 5.5 RF00005 URS000011107D_300852 15802605 0030533 0006412 300852 gcggauuuagcucaguugggagagcgccagacugaagaucuggagguccuguguucgauccacagaauucgcacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... ((.((((..((((.....[..)))).(((((.......))))).....(((((..]....))))))))).)).... Crystal structure of 70S ribosome with thrS operator and tRNAs.; tRNA Phe (unmodified bases) 4v4p B1 66 5.5 15802605 uaacuuuguaugugaucuaucgugugggucaccacugcaaauaaggagguaaaaaugccuguuaua ....<<<<<..<<<<<<<.......>>>>>>>....>>>>>......................... ....((((...((((.(.........).)))).....))))......................... Crystal structure of 70S ribosome with thrS operator and tRNAs.; thrS mRNA operator 4v4q AA 1530 3.46 RF00177,RF01959,RF01960 URS00000ABFE9_562 16272117 0003735 0005840 562 ugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggauca ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<<<..>>>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<.<.......>>>.>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<.<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>..>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((((((((..)))))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(...(((((((.(.......))).)))).)...)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))...((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.....]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Crystal structure of the bacterial ribosome from Escherichia coli at 3.5 A resolution.; 16S ribosomal RNA 4v4q BA 117 3.46 RF00001 URS0000049E57_562 16272117 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggc <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>> (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))) Crystal structure of the bacterial ribosome from Escherichia coli at 3.5 A resolution.; 5S ribosomal RNA 4v4q BB 2841 3.46 RF02540,RF02541 URS00004B0F34_562 16272117 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaacaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauggaaguguggacgccagucugcauggcuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.<...<<<...<<<.<<<<.......>>>>.>>>..>>.>...>.>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.......<<<<<..<<....>>...>>>>>.......>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<.....<<<<<<<<....>>>>>>>>....>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<<...>>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((...(((((((((.(...(((...(((.((((.......)))).)))..)).)...).)))))).)))...))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((..((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((.....{{{....)))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((((.(...(((((((......)))))))..).)))).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((...))))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Crystal structure of the bacterial ribosome from Escherichia coli at 3.5 A resolution.; 23S ribosomal RNA 4v4q CA 1530 3.46 RF00177,RF01959,RF01960 URS00000ABFE9_562 16272117 0003735 0005840 562 ugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggauca ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<<....>>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<.<.......>>>.>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((((((((..)))))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(...(((((((.(.......))).)))).)...)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((..(((((((....)))))))...((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.....]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Crystal structure of the bacterial ribosome from Escherichia coli at 3.5 A resolution.; 16S ribosomal RNA 4v4q DA 117 3.46 RF00001 URS0000049E57_562 16272117 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggc <<<<<<<<<.....<<<<<<<<.....<<<<<<.............>>>>..>>....>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>> (((((((((.....((((((((.....((((((...(.....)...))))..))....)))))).)).((.......((((((((...)))))))).......))...))))))))) Crystal structure of the bacterial ribosome from Escherichia coli at 3.5 A resolution.; 5S ribosomal RNA 4v4q DB 2841 3.46 RF02540,RF02541 URS00004B0F34_562 16272117 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaacaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauggaaguguggacgccagucugcauggcuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<.......>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.......<<<<<..<<....>>...>>>>>.......>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<.......<<<<<<<....>>>>>>>......>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>.(<<...<<<<<<<...<<<<<<.......>>>>>>.....<<)..(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<<...>>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((...(((((((((.(...(((...(((.((((.......)))).)))..)).)...).)))))).)))...))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((..((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((.....{{{....)))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((((.(...(((((((......)))))))..).)))).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((...))))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Crystal structure of the bacterial ribosome from Escherichia coli at 3.5 A resolution.; 23S ribosomal RNA 4v4r AA 1515 5.9 RF00177,RF01959,RF01960 URS000080E226_300852 16377566 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucaccuccuuu ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<.......>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<...<<<<<<......>>>>>.>...>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>...<<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..>.......<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>...<<<<....>>>>...>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<...<<<.....>>>.>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>.........<.<<<<<<<........>>>>>>>>.........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>.............. ....[[......(((....]].((((.((((...((((((.(.....(((.(((..(((..((.((((((((((.....)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(.(((....))).).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..(((.((((....))))....)))))).(((((............))))).((((....))))...)))))).......(.(((...(((((....)))).))))).)..))))))..((((.......(((....)))......))))....(((((...(....((((.....)))).....)....)))))......((((([.[...(((((.....((.].])).......))))))))))...))))))))..........((([[...(.((((....((.(((((((.(((((((((.......((((((.....)))))).....)))))))..)))))))))..((((((((....((((((((....((((((....((........)).......))))))....).......((....)).)))))))...)))).)))..)))....))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...)))..(((((.(((((((.((.((((.(..((((.(((((......((........))..........(((((((......(((((((.....(((((....)))))...(.((((....)))).).)))))))..((.(((...((((((.((...(((((((((....)))...(((......)))...)))))).....((((.(((((((..(....(((.....)))..)...))))))).....(((((....)))))........))))....)).).)))...)).)))))....)))))))...)).))).)))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..).))))....(((((((..........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}............. Crystal structure of the whole ribosomal complex.; 16S ribosomal RNA 4v4r AV 76 5.9 RF00005 URS000011107D_562 16377566 0030533 0006412 562 gcggauuuagcucaguugggagagcgccagacugaagaucuggagguccuguguucgauccacagaauucgcacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... .((.(.(..((((........)))).((((.........)))).....((.((.......)).))).).))..... Crystal structure of the whole ribosomal complex.; P-site tRNA (Phe) 4v4r AW 76 5.9 RF00005 URS000011107D_562 16377566 0030533 0006412 562 gcggauuuagcucaguugggagagcgccagacugaanaucuggagguccuguguucgauccacagaauucgcacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... .((((((..((((.....[..)))).((((.........)))).....(.(((..]....))).)))))))..... Crystal structure of the whole ribosomal complex.; E-site tRNA (Phe) 4v4r AX 17 5.9 URS000080DE6C_32630 16377566 32630 uguucuaguacaauaau ................. ................. Crystal structure of the whole ribosomal complex.; 5'-R(*AP*UP*GP*UP*UP*CP*UP*AP*GP*UP*AP*CP*AP*AP*UP*AP*AP*U)-3' 4v4r BB 123 5.9 RF00001 URS00001170B4_274 16377566 0003735 0005840 274 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcgggggau ..<<<<<<<<<<<....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>>. ..(((((((.((.....(((.((((....(((((((...(.....)...))))..)))...)))).).))(((.......((((((((....)))))))).......)))..)).))))))). Crystal structure of the whole ribosomal complex.; 5S ribosomal RNA 4v4r BA 2814 5.9 RF02540,RF02541,RF00002 URS000080E1D6_300852 16377566 0003735 0005840 300852 ggucaagaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaugcggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgaggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucuugacc <<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<..........>>>>>..<.............>.>>....<<<<<.....<......>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<............<<<<...<<........<<<<........>>>>((......<<<.....))>>>..........>>...>>>>........>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<...<.....<......>.....>.....<<....>>...<<......>>.......>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<..<<<...<<<((......<<<<<<<..........<<..<<<<<<<<<........<<<<..<<...<<<.........>>>...>>.........<........>....>>>>....>>>>>>>>>.>>...........))......>>>>>>>.>>>...>>>.>>><<<<<<<.......>>>>>>>....>>>>>><<<<<<.....<.......<<<<<.<......>.>>>>>....>....>>>>.>>.....>>>>>>.......<......<<<<<<.......>>>>>><<<<....<<<<<.<.<..<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<.<...<<<.....<<<<<.<<...<<<<<.<<<<.<<...[[[...>>>>>><.....<<...<<.<<<<<<<...<......>.>>>>>>....>.>>..>>.....>.......................>>>>>....>>..>>>>>.........>>>....>....>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<<.<<........>>..>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>.>...........<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<..<<<<<<<<<<<<<...>>>>>>>>>>>>>...<<<<......>>>>.....>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<..<<<<<<<...<<.......>>...>>>>>>>...>>>.>.......<.<<<.<.<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>...>...>>>..>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]].>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<.<.....>>......<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>>> .(((.(((......((((((((((.....(((..((((((((((((.(....((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))...)(((....)))(((((..........)))))..................))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...(((.....((((.((.....)).)))).......(((.((.(...........(.(....((....(...(((((......)))))[[(...).(((.....]])))....).....)).....)).......).))..))).....((((((((.........))))))))......(((((..[[[[)))))..)))......)).)))))).))...............((....))....)).........((((....)))).............).....)))))))))).......((((((((((......))))))))))...(............).((((((....(((((((((((((............................((....))....(.......).......)))))))))))))...(.(...((((((....(((((((((((.((((...((((((......))))))...).)))...(((..((((........)))).)))..).))))))))))..(((.....)))......))))))......).)...((((((.....((((....))))..((((((((.(.(..((((((((...(((...((((((((...((((((......)))).))...))))))))..)).)...))))))))..).).))))))).)...(((((((..(......)..))))))).......(......).....((...(((...((([[......(((((((..........((..((((((.(((.......((.((.(((..(.(.........).)..))).........((......))...)).))...))).)))))).))...........]]......))))))).)))...)))..))((((((((.....))))))))....))))))(.((((....(((......(((((..........)))))...)))...))))..).....)))))).......((.....((((((.......))))))((((....((((..((...((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((.............((((..((...(((((.((((.(.....{.....)))))(.....((...(...((((((............))))))........).)).....).......................)))))....))...)))).....................)))))))))))))))..)).....((......)).)))).((((......))))..))))..((((....((((((((.((.......(........((((....(....).....)))).((((((((.............))))))))(...).......(((((((((...((.........))...(((((((.....(((.(.)))).......)))))))..((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(.(((.........))).)........((..........(((((.......)))))..)..)....))))...)).))))))).)...)).)))))))).))))))...........(((((........)))))..((.(((((.(((..(......((((.((((((..(((((.(((.((.((.(((((..((.(((...))).))..)))))...(((........)))....)).)).)))..)))))..((.........))((((((...........))))))([((....(((.((...((((((.......)))))).....((]..[..))....)).)))....((((...((...{..))...)))).(((....))).))..].......((.(((..((..]]]]..)).))).)).....)}......))))..)))))).......((((...((((.(...((.......))...).))))....))).)..........((.((((((..((.(((.((......)).)))...)).(((((.....))))).....)))))..)...))........(.(((((....))).)).)....)...)))))))).))....((((((....(.((..(((((((.....(....)....)))))))...(((...(((....(((((((..((..}.))..))...)))))....))).))).....(((....(((...............)))....))).)).)........))))))...(.(.....))......(((((((((.......)))))....((((((((..........((......))..........))))).)))...))))....))).))). Crystal structure of the whole ribosomal complex.; 23S ribosomal RNA 4v4s AA 1515 6.76 RF00177,RF01959,RF01960 URS000080E226_300852 16377566 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucaccuccuuu ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<.......>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<...<<<<<<......>>>>>.>...>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>...<<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..>.......<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<<....>>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<...<<<.....>>>.>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>.........<.<<<<<<<........>>>>>>>>.........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>.............. ....[[......(((....]].((((.((((...((((((.(.....(((.(((..(((..((.((((((((((.....)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(.(((....))).).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..(((.((((....))))....)))))).(((((............))))).((((....))))...)))))).......(.(((...(((((....)))).))))).)..))))))..((((.......(((....)))......))))....(((((...(....((((.....)))).....)....)))))......((((([.[...(((((.....((.].])).......))))))))))...))))))))..........((([[...(.((((....((.(((((((.(((((((((.......((((((.....)))))).....)))))))..)))))))))..((((((((....((((((((....((((((....((........)).......))))))....).......((....)).)))))))...)))).)))..)))....))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...)))..(((((.(((((((.((.((((.(..((((.(((((......((........))..........(((((((......(((((((.....(((((....)))))...(.((((....)))).).)))))))..((.(((...((((((.((...(((((((((....)))...(((......)))...)))))).....((((.(((((((..(....(((.....)))..)...))))))).....(((((....)))))........))))....)).).)))...)).)))))....)))))))..[)).))).)))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..).))))....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}............. Crystal structure of the whole ribosomal complex.; 16S ribosomal RNA 4v4s AV 76 6.76 RF00005 URS000011107D_562 16377566 0030533 0006412 562 gcggauuuagcucaguugggagagcgccagacugaagaucuggagguccuguguucgauccacagaauucgcacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... .((.(.(..((((........)))).((((.........)))).....((.((.......)).))).).))..... Crystal structure of the whole ribosomal complex.; P-site tRNA (Phe) 4v4s AW 76 6.76 RF00005 URS000011107D_562 16377566 0030533 0006412 562 gcggauuuagcucaguugggagagcgccagacugaanaucuggagguccuguguucgauccacagaauucgcacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... .((((((..((((.....[..)))).((((.........)))).....(.(((..]....))).)))))))..... Crystal structure of the whole ribosomal complex.; E-site tRNA (Phe) 4v4s AX 17 6.76 URS000080DE96_32630 16377566 32630 uguucugauacaauaau ................. ................. Crystal structure of the whole ribosomal complex.; 5'-D(*AP*UP*GP*UP*UP*CP*UP*AP*GP*AP*UP*AP*CP*AP*AP*UP*AP*AP*U)-3' 4v4s BB 123 6.76 RF00001 URS00001170B4_274 16377566 0003735 0005840 274 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcgggggau ..<<<<<<<<<<<....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>>. ..(((((((.((.....(((.((((....(((((((...(.....)...))))..)))...)))).).))(((.......((((((((....)))))))).......)))..)).))))))). Crystal structure of the whole ribosomal complex.; 5S ribosomal RNA 4v4s BA 2814 6.76 RF02540,RF02541,RF00002 URS000080E1D6_300852 16377566 0003735 0005840 300852 ggucaagaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaugcggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgaggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucuugacc <<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<..........>>>>>..<.............>.>>....<<<<<.....<......>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<............<<<<...<<........<<<<........>>>>((......<<<.....))>>>..........>>...>>>>........>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<...<.....<......>.....>.....<<....>>...<<......>>.......>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<..<<<...<<<((......<<<<<<<..........<<..<<<<<<<<<........<<<<..<<...<<<.........>>>...>>.........<........>....>>>>....>>>>>>>>>.>>...........))......>>>>>>>.>>>...>>>.>>><<<<<<<.......>>>>>>>....>>>>>><<<<<<.....<.......<<<<<.<......>.>>>>>....>....>>>>.>>.....>>>>>>.......<......<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<.<...<<<.....<<<<<.<<...<<<<<.<<<<.<<...[[[...>>>>>><.....<<...<<.<<<<<<<...<......>.>>>>>>....>.>>..>>.....>.......................>>>>>....>>..>>>>>.........>>>....>....>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<.<<........>>..>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>...........<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<..<<<<<<<<<<<<<...>>>>>>>>>>>>>...<<<<......>>>>.....>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<..<<<<<<<...<<.......>>...>>>>>>>...>>>.>.......<.<<<.<.<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>...>...>>>..>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]].>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<.<.....>>......<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>>> .(((.(((......((((((((((.....(((..((((((((((((.(....((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))...)(((....)))(((((..........)))))..................))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...(((.....((((.((.....)).)))).......(((.((.(...........(.(....((....(...(((((......)))))[[(...).(((.....]])))....).....)).....)).......).))..))).....((((((((.........))))))))......(((((..[[[[)))))..)))......)).)))))).))...............((....))....)).........((((....)))).............).....)))))))))).......((((((((((......))))))))))...(............).((((((....(((((((((((((............................((....))....(.......).......)))))))))))))...(.(...((((((....(((((((((((.((((...((((((......))))))...).)))...(((..((((........)))).)))..).))))))))))..(((.....)))......))))))......).)...((((((.....((((....))))..((((((((.(.(..((((((((...(((...((((((((...((((((......)))).))...))))))))..)).)...))))))))..).).))))))).)...(((((((..(......)..))))))).......(......).....((...(((...((([[......(((((((..........((..((((((.(((.......((.((.(((..(.(.........).)..))).........((......))...)).))...))).)))))).))...........]]......))))))).)))...)))..))((((((((.....))))))))....))))))(.((((....(((......(((((..........)))))...)))...))))..).....)))))).......((.....((((((.......))))))((((....((((..((...((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((.............((((..((...(((((.((((.(.....{.....)))))(.....((...(...((((((............))))))........).)).....).......................)))))....))...)))).....................)))))))))))))))..)).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(........((((....(....).....)))).((((((((.............))))))))(...).......(((((((((...((.........))...(((((((.....(((.(.)))).......)))))))..((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(.(((.........))).)........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).))))))...........(((((........)))))..((.(((((.(((..(......((((.((((((..(((((.(((.((.((.(((((..((.(((...))).))..)))))...(((........)))....)).)).)))..)))))..((.........))((((((...........))))))([((....(((.((...((((((.......)))))).....((]..[..))....)).)))....((((...((...{..))...)))).(((....))).))..].......((.(((..((..]]]]..)).))).)).....)}......))))..)))))).......((((...((((.(...((.......))...).))))....))).)..........((.((((((..((.(((.((......)).)))...)).(((((.....))))).....)))))..)...))........(.(((((....))).)).)....)...)))))))).))....((((((....(.((..(((((((.....(....)....)))))))...(((...(((....(((((((..((..}.))..))...)))))....))).))).....(((....(((...............)))....))).)).)........))))))...(.(.....))......(((((((((.......)))))....((((((((..........((......))..........))))).)))...))))....))).))). Crystal structure of the whole ribosomal complex.; 23S ribosomal RNA 4v4t AA 1515 6.46 RF00177,RF01959,RF01960 URS000080E226_300852 16377566 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucaccuccuuu ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<.......>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<...<<<<<<......>>>>>.>...>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>...<<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..>.......<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<<....>>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<...<<<.....>>>.>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>.........<.<<<<<<<........>>>>>>>>.........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>.............. ....[[....(.(((....]].((((.((((...((((((.(.....(((.(((..(((..((.((((((((((.....)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(.(((....))).).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..(((.((((....))))....)))))).(((((............))))).((((....))))...)))))).......(.(((...(((((....)))).))))).)..))))))..((((.......(((....)))......))))....(((((...(....((((.....)))).....)....)))))......((((([.[...(((((.....((.].])).......))))))))))...))))))))..........((([[...(.((((....((.(((((((.(((((((((.......((((((.....)))))).....)))))))..)))))))))..((((((((....((((((((....((((((....((........)).......))))))....).......((....)).)))))))...)))).)))..)))....))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...))).)(((((.(((((((.((.((((.(..((((.(((((......((........))..........(((((((......((((((((....(((((....)))))...(.((((....)))).)))))))))..((.(((...((((((.((...(((((((((....)))...(((......)))...)))))).....((((.(((((((..(....(((.....)))..)...))))))).....(((((....)))))........))))....)).).)))...)).)))))....)))))))...)).))).)))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..).))))....(((((((..........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}............. Crystal structure of the whole ribosomal complex with a stop codon in the A-site.; 16S ribosomal RNA 4v4t AV 76 6.46 RF00005 URS000011107D_562 16377566 0030533 0006412 562 gcggauuuagcucaguugggagagcgccagacugaagaucuggagguccuguguucgauccacagaauucgcacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... .((.(.(..((((........)))).((((.........)))).....((.((.......)).))).).))..... Crystal structure of the whole ribosomal complex with a stop codon in the A-site.; P-site tRNA (Phe) 4v4t AW 76 6.46 RF00005 URS000011107D_562 16377566 0030533 0006412 562 gcggauuuagcucaguugggagagcgccagacugaanaucuggagguccuguguucgauccacagaauucgcacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... .((((((..((((.....[..)))).((((.........)))).....(.(((..]....))).)))))))..... Crystal structure of the whole ribosomal complex with a stop codon in the A-site.; E-site tRNA (Phe) 4v4t AX 17 6.46 URS000080DE6C_32630 16377566 32630 uguucuaguacaauaau ................. ................. Crystal structure of the whole ribosomal complex with a stop codon in the A-site.; 5'-D(*AP*UP*GP*UP*UP*CP*UP*AP*GP*UP*AP*CP*AP*AP*UP*AP*AP*U)-3' 4v4t BB 123 6.46 RF00001 URS00001170B4_274 16377566 0003735 0005840 274 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcgggggau ..<<<<<<<<<<<....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>>. ..(((((((.((.....(((.((((....(((((((...(.....)...))))..)))...)))).).))(((.......((((((((....)))))))).......)))..)).))))))). Crystal structure of the whole ribosomal complex with a stop codon in the A-site.; 5S ribosomal RNA 4v4t BA 2814 6.46 RF02540,RF02541,RF00002 URS000080E1D6_300852 16377566 0003735 0005840 300852 ggucaagaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaugcggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgaggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucuugacc <<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<..........>>>>>..<.............>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<............<<<<...<<........<<<<........>>>>((......<<<.....))>>>..........>>...>>>>........>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<...<.....<......>.....>.....<<....>>...<<......>>.......>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<..<<<...<<<((......<<<<<<<..........<<..<<<<<<<<<........<<<<..<<...<<<.........>>>...>>.........<........>....>>>>....>>>>>>>>>.>>...........))......>>>>>>>.>>>...>>>.>>><<<<<<<.......>>>>>>>....>>>>>><<<<<<.....<.......<<<<<.<......>.>>>>>....>....>>>>.>>.....>>>>>>.......<......<<<<<<.......>>>>>><<<<....<<<<<.<.<..<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<.<...<<<.....<<<<<.<<...<<<<<.<<<<.<<...[[[...>>>>>><.....<<...<<.<<<<<<<...<......>.>>>>>>....>.>>..>>.....>.......................>>>>>....>>..>>>>>.........>>>....>....>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<<.<<........>>..>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>.>...........<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<..<<<<<<<<<<<<<...>>>>>>>>>>>>>...<<<<......>>>>.....>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<..<<<<<<<...<<.......>>...>>>>>>>...>>>.>.......<.<<<.<.<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>...>...>>>..>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]].>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<.<.....>>......<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>>> .(((.(((......((((((((((.....(((..((((((((((((.(....((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))...)(((....)))(((((..........)))))..................))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...(((.....((((.((.....)).)))).......(((.((.(...........(.(....((....(...(((((......)))))[[(...).(((.....]])))....).....)).....)).......).))..))).....((((((((.........))))))))......(((((..[[[[)))))..)))......)).)))))).))...............((....))....)).........((((....)))).............).....)))))))))).......((((((((((......))))))))))...(............).((((((....(((((((((((((............................((....))....(.......).......)))))))))))))...(.(...((((((....(((((((((((.((((...((((((......))))))...).)))...(((..((((........)))).)))..).))))))))))..(((.....)))......))))))......).)...((((((.....((((....))))..((((((((.(.(..((((((((...(((...((((((((...((((((......)))).))...))))))))..)).)...))))))))..).).))))))).)...(((((((..(......)..))))))).......(......).....((...(((...((([[......(((((((..........((..((((((.(((.......((.((.(((..(.(.........).)..))).........((......))...)).))...))).)))))).))...........]]......))))))).)))...)))..))((((((((.....))))))))....))))))(.((((....(((......(((((..........)))))...)))...))))..).....)))))).......((.....((((((.......))))))((((....((((..((...((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((.............((((..((...(((((.((((.(.....{.....)))))(.....((...(...((((((............))))))........).)).....).......................)))))....))...)))).....................)))))))))))))))..)).....((......)).)))).((((......))))..))))..((((....((((((((.((.......(........((((....(....).....)))).((((((((.............))))))))(...).......(((((((((...((.........))...(((((((.....(((.(.)))).......)))))))..((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(.(((.........))).)........((..........(((((.......)))))..)..)....))))...)).))))))).)...)).)))))))).))))))...........(((((........)))))..((.(((((.(((..(......((((.((((((..(((((.(((.((.((.(((((..((.(((...))).))..)))))...(((........)))....)).)).)))..)))))..((.........))((((((...........))))))([((....(((.((...((((((.......)))))).....((]..[..))....)).)))....((((...((...{..))...)))).(((....))).))..].......((.(((..((..]]]]..)).))).)).....)}......))))..)))))).......((((...((((.(...((.......))...).))))....))).)..........((.((((((..((.(((.((......)).)))...)).(((((.....))))).....)))))..)...))........(.(((((....))).)).)....)...)))))))).))....((((((....(.((..(((((((.....(....)....)))))))...(((...(((....(((((((..((..}.))..))...)))))....))).))).....(((....(((...............)))....))).)).)........))))))...(.(.....))......(((((((((.......)))))....((((((((..........((......))..........))))).)))...))))....))).))). Crystal structure of the whole ribosomal complex with a stop codon in the A-site.; 23S ribosomal RNA 4v4v AA 1488 15.0 RF00177,RF01959,RF01960 URS000080DE6D_562 16713583,16714018 0003735 0005840 562 ugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguccggaagaagcuuucuuuuggacaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagguuuucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucgcggggaggaagggagcgacgagcucauugacguuacccgcgaaguagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugucucguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgacuacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcaaccuucggggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggauca ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<<<<<<<<<.....>>>>>>>>>>.>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<...>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<<<<<<.......<<<<<.....>>>>.>........>>>>>>.....<<<<<.(....<<<<<.....<<..).>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<...>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<.......<<<<<<<....>>>>>>>...<<<..>>>........>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<..<.....<<<..<....<<<....>>>....>....>>>.....>..>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>....>>>>>>>>>>.>>....<...<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.....<<....>>..>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>....>.....<<<<<<<<<....>>>>>>>>>...... ....((((..[.[[[..)))).((((.(((((..((((((((.....(((.(((..(((..((.((((((((((.....)))))))))).)))))......(((......(((((((..((...(.(((((.(.((.....((((.(....).))))......)).).....(((....)))....(((.....))).))))).)..)).)))))))(((....(((..((((((.(.......).)))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).........(((...(((((....)))).))))..)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[....(((((.....((..]])).......))))))))))..)))))))))..........(((.[.....((((...(((.(.(((.(.((((((((((......(((.((.....)).)))....))))))))..))).))).)...(((.((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))..)))...)))...))))....((((((...((...((((.........))))...))))))))..........((((((..(((.(.((.......)).).)))...((.]..)).....)))))).))).(((......(.((....)).)....)))...]]].](((((.(((((((.....(((((..((((((((((......((........))..........(((((((..(...((........((.(((....))).))....(((..)))........))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((.(.(((((((...(...(((.....)))).....)))))))..(..(((((....))))).....)..).)).....).).)))...)).)))))....)))))))...)).)))))))).....((((........(((..((...(((....)))...))....)))........))))......(....(((((((........)))))))....).....))))).....(((((((.........)))))))...........)))))))))).))....(...(.(.((((.(((..(((..((.((((....((((((.....((....))..))))))...)))).))..)))..))).))))..).)....).....(((((((((....)))))))))...... Structure of a pre-translocational E. coli ribosome obtained by fitting atomic models for RNA and protein components into cryo-EM map EMD-1056; 16S ribosomal RNA 4v4v AU 76 15.0 RF00005 URS000011107D_562 16713583,16714018 0030533 0006412 562 gcggauuuagcucaguugggagagcgccagacugaagaucuggagguccuguguucgauccacagaauucgcacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((.........)))).....(((((..]....)))))))))))).... Structure of a pre-translocational E. coli ribosome obtained by fitting atomic models for RNA and protein components into cryo-EM map EMD-1056; tRNA 4v4v AV 76 15.0 RF00005 URS000011107D_562 16713583,16714018 0030533 0006412 562 gcggauuuagcucaguugggagagcgccagacugaagaucuggagguccuguguucgauccacagaauucgcacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((.........)))).....(((((..]....)))))))))))).... Structure of a pre-translocational E. coli ribosome obtained by fitting atomic models for RNA and protein components into cryo-EM map EMD-1056; tRNA 4v4v AW 76 15.0 RF00005 URS000011107D_562 16713583,16714018 0030533 0006412 562 gcggauuuagcucaguugggagagcgccagacugaagaucuggagguccuguguucgauccacagaauucgcacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((.........)))).....(((((..]....)))))))))))).... Structure of a pre-translocational E. coli ribosome obtained by fitting atomic models for RNA and protein components into cryo-EM map EMD-1056; tRNA 4v4v B0 2740 15.0 RF02540,RF02541 URS000080E20A_562 16713583,16714018 0003735 0005840 562 cguacacgguggaugcccuggcagucaaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuuaaccggcgauuuccgaauggggaaccccgaucauuauccaaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccgagccuaaucaguguguguguuguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaugcacaugcuguagcucgaugaguagggcgggccgugguaccugucugaauauggggggaccauccuccaaggcuaaauacucugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggaggcaccuuaugcguguuauggcgugccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccggggagccgaagggaaaccgagucuuaacgggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaaucaucuccggggguagagcacuguuucggcaagggggucgacuuccaacccgaugcaaacugcgaauaccggagauguuaucacgggagacacacggcggguguaacguccgucgugaagagggaaacaacccagaccgcagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguacggggcuaaaccaugcaccgaagcugcggcagcgacguuaugcguuguuggguaggggagcguucuguagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgacccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuuggugugugggugauggagggacggagaaggcuauguuaugccaagcuauggcugcugguugguacgcucaagggcgaucgggucagaaaaucuaccggucacaugccucagacguaucgggagcuuccucggaagcgaaguaacaaagcccucuuccaggaaaagcuucuaaacguugaaacaugucaaaucguaccccaaaccgacacagguggucagguagagaauaccaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauuagcucgccugaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaaugggguugcaaagcucucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccggccuugaaauaccacccuuuaauguuugauguucuaacccgaauccggggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggcaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccgguggucugaauggaagggccaucgucaacggaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucagccauggcacugcccgguagcuaaaugcggagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccgaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcaaugcguugagcuaaccgguacuaaugaaccgaggucuugacca <<<<<<<<<<.....<<..<<<<<<<<<<<..........<<<.[...((.>>>......<<<<<<..<<<))...].>>>.....>>>>>>............<<...>>....<<<<<.....>>>>>..>...<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<.<<<<.....<<<<<..<<<<<<<<<....<<<<......>>>>.((......<<<.....))>>>...>>>>>>>>..>>>>>>..>>>>........<<<<<<<........>>>>>>>......<<<<<..[.[.>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<.....>>>>..................>>>>>>>>>>.........<.....<<<<.......>>>>....>....<.<........>.>.<<<<<<.....<<<<<<<<<<<<..<<<..........>>>...<<....>>..<<<<....>>>>.....>>>>>>>>>>>>...<<................<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>....................>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<..<<.<<<<<<.<...<<<...<<<.<<<<...<<<<<<..>>>>>>...>>>>.>>>..>>.>...>.>>>>>>.>>...>>>>>>>.>...<<<<<<<<<<.....>>>>>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<..<<...<<<<.......>>>>...>>........<<<......>>>...>>>>....>>..>>>>>.>>..........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<...>>>>>>>>>....>>>>>><<<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>.>>.....>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<.<.<<<....>>>.>.>>>...>>>..<<<<<........>>>>>))<<<<..<<<........<<<....<<<<<.<<<..<<<<..<<<<.<<...(((.>>>>>>..<<<<<.<<.<<<..<<<<<.<............>>>>>>.....>>>..>>>>>>>.....<<<<<....>>>>>.....>>>>..>>>.>>>>>.........>>>............>>>..>>>>.>>>..>>.....<<......>>>>>>>..<<<.....>>>..>>>>..<<<......<<<<<<<.<<...............<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<........<.<<<....<....<<<<<......>>>>>....>..>>>.>.......<<<<<<.......>>>>>>....................<<<<<<.....>>>>>>..........>>>>>..>>.>>>>>>>.....>>.>>>>>>>...>>>>>........(..<<<<<......).>>>>>..<<<<..<<..<...<......<<<<.<<.<<<..<<<<<.<<<.<<<<..<<<<<<<<<<<.<<<..........................................................................>>>.>>>>>>>>>>>...<<<<....>>>>.....>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<....>>>>>.....<<..[.((>>....>>>>>>>...<<<<..<<........>>..>>>>.<<<....>>>.>>))].......<<<<<<<<<...].]..>>>>>>>>>..........>>>...>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>....>.>>..>>>>...<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<..<<<<<<<<<<<))).>>>>>..>>>>>>..>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>......<<..<<<<.........>>>>....<<<<<<<<..<<....<<<........>>>...>>...>>>>>.>>>.....>>............. (((((((((.....(((..((((((((.(...........(((.[...[[.))).......((((...(((]]...].)))......)))).............((...).)...(((((.....)))))......(.((((.....(......)......))))..).........((....))...((((......((.....)).....))))...(((((((......((((......((((((.....(.(......).)..[[......(((.....]])))...))))))......))))...)))...)....((.(.((........)).).))......((.((......)).))..)))......)..)))))).))...............((....))....))......(..((((.....))))............)).....)))))))))................(((.......)))..........(.(........).).((((((....((((.((((.(((..(((..........)))...((....))..((((....)))).....))).)))).))))..((................(((((((.(..((((...((((.(......).))))...).)))...(((..((((........)))).)))....).)))))))...(((.....)))....................))..((((((....(((((....)))))..((((((...((.((((((.....(((...((..((((...((..(....)..))...))))..))..)).).....)))))).))....)))))).....((((((((.........))))))))....(((......)))...(((((((...((([[[...(.((((((.....(.....((..(((((..(..........((....((..(((.........)))..))......(..(((......))))...))......)..))))).))..........]]].)...))))))))))...)))))))...(.((.......)).).......))))))(.(((.....((......((..(((......)))..))...)).....)))..).....))))))..............((((((.......))))))((((....((((..((...((((.(...((.....)).).))))....[[(((.((...(((.(..((....))..).)))...))...(((((........)))))]](((...(((..........(....(((((.((...(((((..(((.((.......)))))...(((((.(.(.....((.(.................).)).......)...)))))).....(((((....)))))....)))))...)).)))))(..).....)..............)))...))).)))..)).....((......)).))))..(((.....)))..))))..((......((((((((..(.......(........((((....(....).....)))).((((((.((.....)).))))))(...).......(((((..((...((.........))...((((.((.....(((....))).......)).))))...(((........(((.....(.....((((........))))......)..))).......((((((.......))))))....................(((((.......)))))..........)))....))...))))).)....).))))))))...))..........[..(.(((......].))).)..((....((..((.........((((.(((((...(((((..(..((((..((((((..(.(.((...(....................................................................)...)).).)..))))))...((((....)))).....))))..)...)))))..(((......[)))(((.((..........])).)))(.((...((.((((.(.(((((....)))))...).((...[[[))....)))).))...((((..((........))..))))..((....))..))]]].......((.(((.((........)).))).))....)......)))..)))))).......((((...((((((...((.......))...))))))....))).).......(((((.((.(((..(((((((((......))))))..)))..((((.....))))......))).)..)...))).))....(((((((....))).))))........)).))....))...(((((...((((..((.((((.....(....)....)))).)).(..((...(.((...(((((.((((....))))...)))))...)).).))..)..(((....((((.............))))....))).)))).......))))).......(..(((.(.......).)))....(((.((((..((....(((........)))...))...))))..))).....).............. Structure of a pre-translocational E. coli ribosome obtained by fitting atomic models for RNA and protein components into cryo-EM map EMD-1056; 23S ribosomal RNA 4v4v B9 108 15.0 RF00001 URS000080E173_562 16713583,16714018 0003735 0005840 562 ggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguaggaacugcc <<<<<.....<<<<<<<.....<<<<<<<.............>>>>..>>>....>>>>>.>>.<<.<<....<<<<<<<<...>>>>>>>>....>>.>>..>>>>> (((((..........(((....(((((((.............))))..)))...)))........(.(.....((.(((((...))))).)).....).)...))))) Structure of a pre-translocational E. coli ribosome obtained by fitting atomic models for RNA and protein components into cryo-EM map EMD-1056; 5S ribosomal RNA 4v4w AA 1488 15.0 RF00177,RF01959,RF01960 URS000080DE6D_562 16713583,16714018 0003735 0005840 562 ugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguccggaagaagcuuucuuuuggacaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagguuuucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucgcggggaggaagggagcgacgagcucauugacguuacccgcgaaguagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugucucguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgacuacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcaaccuucggggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggauca ....<<<<....((((.>>>>.<<<<..<......<<<<<<<.....<<<.<<<..<<<..<<.<<<<<<<<<<.....>>>>>>>>>>.>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<...>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>...>>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>...<<<<......<<<<<..>>>>>.....>>>>..<<<<<<<.......<<<<<.....>>>>.>........>>>>>>>....<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>......>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<.<.<<<......>>>.....>>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<...>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>..<<......<<<<....>>>>....>>...))))..<<<<<.<<<<<<<.....<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<.......<<<<<<<....>>>>>>>...<......>........>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<..<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>.........>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>......<<<........<<<..<....<<<....>>>....>....>>>........>>>............<<<<<<<........>>>>>>>..........>>>>>.....<<<<<<<.........>>>>>>>...........>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.....<<....>>..>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>...... ....((((.....[[..))))..((.......(...((((((.....(((.(((..(((..((.((((((((((.....)))))))))).)))))......(((......(((((((..((...(.(((((.(.((.....((((.(....).))))......)).).....(((....)))....(((.....))).))))).)..)).)))))))(((....(((..((((((.(.......).)))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).........(((...(((((....)))).))))..)).)))).....(........((((....)))).......).....(((((........((((.....))))..........)))))......((((([[[....((((.....((.]]])).......)))).)))))..).....))...........((([[.....(((....(((...(((.(.((((((((((......(((.((.....)).)))....))))))))..))).))).....(((.((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))..)))...)))....)))....((((((...((...((((.........))))...))))))))..........((((((..(((.(.((((...)))).).)))...((..]])).....)))))).)))...(......(.((....)).)....).....]]....(((..(((((.(.......(((..((((((..........((........))...........((((((......(.........((.(((....))).))....((....)).........)..((.(((...((((((.(....(((((((((....)))...((........))...)))))).....((.(.(((((((...(...(((.....)))).....))))))).....(((((....)))))........).)).....).).)))...)).)))))....)))))).........)))))).......((........(((..((...(((....)))...))....)))........))........(....(((..((........))..)))....).....))).......(((((((.........)))))))...........).))))).)).)........((.(.((((.(((..(((..(((((((....((((((.....((....))..))))))...)))))))..)))..))).))))..).)).........(((((((((....)))))))))...... Structure of a SecM-stalled E. coli ribosome complex obtained by fitting atomic models for RNA and protein components into cryo-EM map EMD-1143; 16S ribosomal RNA 4v4w AU 76 15.0 RF00005 URS000011107D_562 16713583,16714018 0030533 0006412 562 gcggauuuagcucaguugggagagcgccagacugaagaucuggagguccuguguucgauccacagaauucgcacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((.........)))).....(((((..]....)))))))))))).... Structure of a SecM-stalled E. coli ribosome complex obtained by fitting atomic models for RNA and protein components into cryo-EM map EMD-1143; tRNA 4v4w AV 76 15.0 RF00005 URS000011107D_562 16713583,16714018 0030533 0006412 562 gcggauuuagcucaguugggagagcgccagacugaagaucuggagguccuguguucgauccacagaauucgcacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((.........)))).....(((((..]....)))))))))))).... Structure of a SecM-stalled E. coli ribosome complex obtained by fitting atomic models for RNA and protein components into cryo-EM map EMD-1143; tRNA 4v4w AW 76 15.0 RF00005 URS000011107D_562 16713583,16714018 0030533 0006412 562 gcggauuuagcucaguugggagagcgccagacugaagaucuggagguccuguguucgauccacagaauucgcacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((.........)))).....(((((..]....)))))))))))).... Structure of a SecM-stalled E. coli ribosome complex obtained by fitting atomic models for RNA and protein components into cryo-EM map EMD-1143; tRNA 4v4w B0 2740 15.0 RF02540,RF02541 URS000080E20A_562 16713583,16714018 0003735 0005840 562 cguacacgguggaugcccuggcagucaaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuuaaccggcgauuuccgaauggggaaccccgaucauuauccaaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccgagccuaaucaguguguguguuguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaugcacaugcuguagcucgaugaguagggcgggccgugguaccugucugaauauggggggaccauccuccaaggcuaaauacucugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggaggcaccuuaugcguguuauggcgugccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccggggagccgaagggaaaccgagucuuaacgggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaaucaucuccggggguagagcacuguuucggcaagggggucgacuuccaacccgaugcaaacugcgaauaccggagauguuaucacgggagacacacggcggguguaacguccgucgugaagagggaaacaacccagaccgcagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguacggggcuaaaccaugcaccgaagcugcggcagcgacguuaugcguuguuggguaggggagcguucuguagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgacccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuuggugugugggugauggagggacggagaaggcuauguuaugccaagcuauggcugcugguugguacgcucaagggcgaucgggucagaaaaucuaccggucacaugccucagacguaucgggagcuuccucggaagcgaaguaacaaagcccucuuccaggaaaagcuucuaaacguugaaacaugucaaaucguaccccaaaccgacacagguggucagguagagaauaccaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauuagcucgccugaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaaugggguugcaaagcucucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccggccuugaaauaccacccuuuaauguuugauguucuaacccgaauccggggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggcaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccgguggucugaauggaagggccaucgucaacggaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucagccauggcacugcccgguagcuaaaugcggagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccgaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcaaugcguugagcuaaccgguacuaaugaaccgaggucuugacca <<<<<<<<<<.....<<..<<<<<<<<<<<<.........<<<.[...((.>>>.....<<<<<<<..<<<))...].>>>.....>>>>>>>...........<<...>>....<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<.<<<<.....<<<<<<...<.<..<.....<<<<......>>>>.(.......<<<......)>>>....>.>..>...>>>>>>..>>>>........<<<<<<<........>>>>>>>......<<<<<..[[..>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<.....>>>>..................>>>>>>>>>>.........<....<<<<<.......>>>>>...>....<.<........>.>.<<<<<<......<<<<<<<<.<<..<<<..........>>>...<<....>>..<<<<....>>>>.....>>.>>>>>>>>....<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>..<<...<<..<<...<<<<.<....<<...<...<<<<...<<<<<<..>>>>>>...>>>>...>..>>.....>.>>>>...>>...>>...>>......<<<<<<<<.......>>>>>>>>.....<<<......>>>...<<<<<<<...<<<((......<<<<<.<...........<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>............)).....>>>>>>.>>>...>>>>>>>..<<<<<<<...>>>>>>>......>>>>>>...<<<<..<<<<.....<<<<<<<<....>>>>>>>>..>>>>..>>>>.........>>>>>><.............<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<....<<<.<.<<<....>>>.>.>>>....>>...<<<<........>>>>.))<<<<..<<<........<<<....<<<<<.<<<..<<<<..<<<<.<<...(((.>>>>>>..<<<<<.<<.<<<..<<<<<.<............>>>>>>.....>>>..>>>>>>>.....<<<........>>>.....>>>>..>>>.>>>>>.........>>>............>>>..>>>>.>>>..>>.....<<......>>>>>>>..<<<.....>>>..>>>>..<<<.........<<...<<...............<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>..<<<<..<<....<..<<..<<<....<<<<<......>>>>>....>>>>>..>....>>.<<<<<<.......>>>>>>....................<<<<<<.....>>>>>>..........>>>>...>>.>>>>>>>.....>>....>>.....>>>.......>.....<<<<<........>>>>>..<<<<<<<<.<<<.<<.......<<<...<<.<...<..............<<<<<<<<<<<.<<.<.........................................................................>>>.>>>>>>>>>>>...<<<<....>>>>..................>...<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<....>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<........>>..>>>>.<<<....>>>.>>))).........<<<<<<<....]]..>>>>>>>.............>>>....>.>>.........<<.<.<<<<<<...<<.......>>...>>>>>>...>>>..........<.........<<....<<<<<<<......>>>>>>>.......<<.......>>.......>>..............>....<<<<<<<....>>>.>>>>....>>..>>>>>>>>>>>...<<<<....<<<<..<<<<<<.................>>>>>>.<<<<<...<<<<..<<<<<<.<<<<))).>>>>...>>>>>>..>>>>.>>>>>..<<<.<..<<<<<...........>>>>>...>>>>.>>>>........>>>>......<<..<<<<.........>>>>....<<<<<<<<..<<....<<<........>>>...>>...>>>>>.>>>.....>>............. (((((((((.....(((..((((((((.(.(.........(((.[...[[.)))......(.(((...(((]]...].)))......))).)............((...).)...(((((.....))))).)....((((((.....(...[..)......))))).).........((....))...((((......((.]...)).....))))...(((((((......((((.......(........((((......)))).[[......(((.....]])))......)........))))...)))...)....((.(.((........)).).))......((.((......)).))..)))......)..)))))).))...............((....))....))...................................).....)))))))))................(((.......)))..........(.(........)..)((((((.....(.(.(((.......(((..........))).............((((....))))..........))).).)....(.(....(((((.....(((((((.(..((((...((((.(......).))))...)[)))....((..((((........)))).)).....).)))))))....((.....)).......))))).......).)...((((((.....((((....)))).....(..........(..(.......(........((((...((..........))...)))).......)........)...)...........)......((((((((.{.......))))))))....(((......)))...(((((((...((([[....(.(((..(.....(.....((..(((((.............((((.((...(((.........)))...)).....(..(((......)))).)))).........))))).))...........]].)...)..)))))))...)))))))..(((((.......)))))......))))))(.((......((.......(..((((....))))..)....))......))..).....))))))..............((((((.......))))))((((....((((..((..(((((.(...((.....)).).))))....[[(((.(....(((.(..((....))..).)))....)....((((........)))).]](((...(((.........((....((((..((...(((((..(((.((.......)))))...(((((.(....(..((.((...............)).)).....).....)))))).....((..........))....)))))...))..))))(..).....)).............)))...))).))).))).....((......)).))))..(((.....)))..))))...(((...........(.((..(.............((((....(....).....)))).((((((.((.....)).))))))(...).......((((((.((.].((.........))...((((.((.....(((....))).......)).))))...(((......(....((..........((((......))))........))......).....((((.......))))......................(((((.......)))))..........)))....))..))))))....))).)........)))..............(.(((........))).)..(((.(((...((.((.................(.................((((.((((.(....(.........................................................................)...).)))).))))...((((....))))......................(((.}.....)))((...(...........)...))..((...((.((((.(.(((((....)))))...).((...[[[))....)))).))...((((..((........))..))))..((....))..))]]]...........(.(((........))).)..............)....................((...((((((...(.........)...))))))....)).............(......(....(.(((((........)))))...)....(.........)........)...........).......(((((((....))).))))....))..))..))).)))...(.......((((..((.((.......(....)......)).))....((...(.((...(((((.((((....))))...)))))...)).).))......((....((((.............))))....))..))))...........)......((..(((.(.......).)))....(((.((((..((....(((........)))...))...))))..))).....))............. Structure of a SecM-stalled E. coli ribosome complex obtained by fitting atomic models for RNA and protein components into cryo-EM map EMD-1143; 23S ribosomal RNA 4v4w B9 108 15.0 RF00001 URS000080E173_562 16713583,16714018 0003735 0005840 562 ggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguaggaacugcc <<<<<.....<<<<<<<.....<<<<<<<.............>>>>..>>>....>>>>>.>>.<<.<<....<<<<<<<<...>>>>>>>>....>>.>>..>>>>> ((.((..........(((.....((((((.............))))..))....)))........(.......((((((.(...).)))))).......)...)).)) Structure of a SecM-stalled E. coli ribosome complex obtained by fitting atomic models for RNA and protein components into cryo-EM map EMD-1143; 5S ribosomal RNA 4v4x AA 1515 5.0 RF00177,RF01959,RF01960 URS000080E226_300852 17051149 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucaccuccuuu ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<...<..<<<.<<<..<<<..<<.<<<<<<<<<.......>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<............>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>...>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<(......<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<...)>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<.......<<<<<<<...<<<<<<....>>>>>>....<<<<....>>>>..>>>>>>>..<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<...<<<.....>>>.>.....>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>.............. ....(((((.[.[[[.))))).((((.(((((..((((((.((....(((.(((..(((..((.(((((((((((...))))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)..))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........(((.....(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((...(((((((....(((......))).......)))))))...).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))..........((((((..((((((((((...))))))))))...((....)).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((......((((((((..(((((((....))))))).(.((((....)))).)))))))))..((.(((...((((((.((...(((((((((....)))..((((......))))..)))))).....((((.(((((((..(.(..(((.....)))).)...))))))).....(((((....)))))........))))....)).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))....(..((...((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))....))...).....(((((((((....))))))))).............. Crystal structure of the 70S Thermus thermophilus ribosome showing how the 16S 3'-end mimicks mRNA E and P codons.; 16S rRNA 4v4x AC 76 5.0 RF00005 URS000041AF00_562 17051149 0030533 0006412 562 cgcgggguggagcagccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.....[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the 70S Thermus thermophilus ribosome showing how the 16S 3'-end mimicks mRNA E and P codons.; tRNA fMET (unmodified bases) 4v4x AD 76 5.0 RF00005 URS000080DFDE_300852 17051149 0030533 0006412 300852 gccgagguagcucaguugguagagcaugcgacugaaaaucgcagugucggcgguucgauuccgcuccucggcacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((........)))).(((((.......))))).....(((((.......)))))))))))).... Crystal structure of the 70S Thermus thermophilus ribosome showing how the 16S 3'-end mimicks mRNA E and P codons.; tRNA PHE (unmodified bases) 4v4x BA 2889 5.0 RF02540,RF02541,RF00002 URS000080E1D6_300852 17051149 0003735 0005840 300852 ggucaagaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaugcggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgaggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucuugacc <<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<........>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<.....<<<<<<<.....>>>>>>>.......<<<<<<<............<<<<...<<..<<<...<<<<<......>>>>><........(.......>.)....>>>....>>....>>>>.......>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..(((.>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<...<.....<......>.....>.....<<....>>...<<......>>.......>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<....<<...<<<<<<<<.<.<<<<<<......>>>>.>>>..>>>>>>>>..>>.....>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<((......<<<<<<<..........<<..<<<<<<<<<.........<.<..<<.....................>>.........<........>....>.>.....>>>>>>>>>.>>...........))......>>>>>>>.>>>...>>>>>>><<.<<<<.......>>>>.>>....>>>>>>.<<<<<<...<<<......<<<<<.<......>.>>>>>...>>>..>>>>>.>......>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<..<<..<<<<<<<...<<.....>>.>>>>>>>...((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<.....<.<.....<<<<..<<<..<<<<<.<<<<.<<...[[[...>>>>>>......<<<..<<.<<<<<<<<.<<.....>>>>>>>>>....>.>>.>>>......<.....<<......>>......>>>>>>...>>>...>>>>.........>..>........>>>>>>>>>>>>>>>..>>.....<<......>>.>>>>.<<<<......>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.<<<........>>>..>>>>>>............<<<<<<<<<..<<<<.......>>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>....................<<<<<<.....>>>>>>..........>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.<<<.<<......<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<......>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<...)))..>>>>>>>>>.............>>>>..>>>>>>........<<<..<<<<<<<...<<.......>>...>>>>>>>...>>>.........<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<..<<<<<<<<<<<<]]].>>>>>>...>>>>>>..>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.....<.....>.......<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>>> ((((((((......(((((((((((....(((..((((((((((.(......((((((([...[[)))).....((((((...(((]]...].)))......))))))...)))....(((....)))((((((((....)))))))).(((..........))).)....((((((.....(...[..)......)))))..)........((....))...(((((.....((.]...))....)))))..((((....((((((((.....))))))))......((((.(((.....((...((((((.(((..(((...(((((......)))))[[(...).(((.....]])))...)))....)))..))))))..)).))).).))).....(((((((((.......)))))))))......((((((.[[.))))))..)))).....)).)))))).))...............((....))....)).........((((....)))).............)....))))))))))).......(((((((((((....)))))))))))...(............).((((((....(((((((((((((..((...................))...((....))..(.((.....)).).....)))))))))))))..((.(...((((((...((((((((((((.((((...((((((......))))))....))))...(((..((((.......<)))).)))..).))))))))))).(((.....)))......))))))......).))..((((((....(((((....))))).((((((((.(...(((((.(((...(((...((((((((...((((((......)))).))...))))))))..)).)...))).)))))...).))))))).)...(((((((.((......)).)))))))...(.(((......))).).((((.(((...(((.[....(.(((((((..........((..((((((((((.......((.((.(((..(((.........)))..)))(...)(...((......)).).)).))...)))))))))).))...........].......)))))))))))...)))))))((((((((.....))))))))....))))))(((((((...(((......(((((.(......).)))))...)))..))))).)).....)))))).......((.....((((((.......))))))((((....((((..(...(((((((...((.....)).)))))))...[[(((..((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((.....((((....((((..(((..(((((.((((.((...{{....))))))(((...((..((((((((((((.((.....)))))))))).....))))))....))).(..((((....))))..)...)))))...)))...)))).........))))........))))))))))).)))...).....((......)).)))).((((......))))..))))..((((....((((((((.(((...............((((....(....).....)))).((((((((.............))))))))(...).......(((((((((..(((((.....)))))..(((((((.....(((....))).......)))))))..((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))((((((.......)))))).........(..........((((((.....))))))..).......))))...)).)))))))....))).)))))))).))))))...........(((((........)))))..((((((((.(((.((......((((.((((((..(((((.(((.((((..((((((((((((((((.(.........(((((..((((.....((((((((....))))))))..))))............)))))).))))))))))))))))...(((((....))))).....)))).)))..)))))..((((.....))))((((((...........)))))).[((...(((((((.(.((((((.......))))))...).((]..[..))....)))))))...((((..(((......)))..)))).(((....))).))..].......(((((((.((....]]..))))))))).............))))..))))))........(((.((((((((...((.......))...))))))))..)))..........((((.((((((..(((((((((......)))))))..)).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.))..)))))))))))....((((((((..((((..(((((((...(.(....).)..))))))).(((((...(((....(((((((((((.}}.))))))...)))))....))).)))))...(((....(((((...........)))))....))).))))......))))))))..((((.....))))....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))....)))))))) Crystal structure of the 70S Thermus thermophilus ribosome showing how the 16S 3'-end mimicks mRNA E and P codons.; 23S ribosomal RNA 4v4x BB 123 5.0 RF00001 URS00001170B4_300852 17051149 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcgggggau ..<<<<<<<<<<<....<<<<<<<<....<<<.<<<.............>>>...>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>>>. ..(((((((((((....((((((((.....((((((.............))))..))....)))))).))(((.......((((((((....)))))))).......))).))))))))))). Crystal structure of the 70S Thermus thermophilus ribosome showing how the 16S 3'-end mimicks mRNA E and P codons.; 5S ribosomal RNA 4v4y AA 1515 5.5 RF00177,RF01959,RF01960 URS000080E226_300852 17051149 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucaccuccuuu ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<...<..<<<.<<<..<<<..<<.<<<<<<<<<.......>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<............>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>...>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<(......<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<....<<<......>>>.......>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<...)>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<.......<<<<<<<..<<<<<<<....>>>>>>>.<.<<<<....>>>>.>>>>>>>>..<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<...<<<.....>>>.>.....>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>.............. ....(((((.[.[[[.))))).((((.((((([.((((((.((....(((.(((..(((..((.(((((((((((...))))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).).]))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........(((.......((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((...(((((((....(((......))).......)))))))...).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))..........((((((..((((((((((...))))))))))...((....)).....)))))).))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((......((((((((..(((((((....))))))).(.((((....)))).)))))))))..((.(((...((((((.((...(((((((((....)))..((((......))))..)))))).....((((.(((((((..(.(..(((.....)))).)...))))))).....(((((....)))))........))))....)).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))....(..((...((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))....))...).....(((((((((....))))))))).............. Crystal structure of the 70S Thermus thermophilus ribosome with translocated and rotated Shine-Dalgarno Duplex.; 16S ribosomal RNA 4v4y A1 50 5.5 17051149 uuuuuuuuuuuuuuuuuggcaaggagguuuuuuuuuuuuuuuuuuuuuuu .................................................. .................................................. Crystal structure of the 70S Thermus thermophilus ribosome with translocated and rotated Shine-Dalgarno Duplex.; mRNA 4v4y AC 76 5.5 RF00005 URS00005AA258_562 17051149 0030533 0006412 562 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).(((((.......))))).....(((((..]....)))))))))))).... Crystal structure of the 70S Thermus thermophilus ribosome with translocated and rotated Shine-Dalgarno Duplex.; tRNA PHE (unmodified bases) 4v4y AD 76 5.5 RF00005 URS00005AA258_562 17051149 0030533 0006412 562 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((((.....)))))).....(((((..]....)))))))))))).... Crystal structure of the 70S Thermus thermophilus ribosome with translocated and rotated Shine-Dalgarno Duplex.; tRNA PHE (unmodified bases) 4v4y AB 76 5.5 RF00005 URS00005AA258_562 17051149 0030533 0006412 562 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((........)))).(((((.......))))).....(((((.......)))))))))))).... Crystal structure of the 70S Thermus thermophilus ribosome with translocated and rotated Shine-Dalgarno Duplex.; tRNA PHE (unmodified bases) 4v4y BA 2889 5.5 RF02540,RF02541,RF00002 URS000080E1D6_300852 17051149 0003735 0005840 300852 ggucaagaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaugcggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgaggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucuugacc <<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<........>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<.......<....<<<<<..<<..<<<...<<<<........>>>>(.......<<.......).>>...>>>....>>...>>>>>...>...>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<...<.....<......>.....>.....<<....>>...<<......>>.......>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<<...<<<<<<......>>>>>>....>>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<.....<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>......>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<((......<<<<<<<..........<<..<<<<<<<<.........<<<<<.<<.....................>>.........<........>...>>>>>.....>>>>>>>>.>>...........))......>>>>>>>.>>>...>>>>>>><<.<<<<.......>>>>.>>....>>>>>><<<<<<<...<<<......<<<<<.<......>.>>>>>...>>>..>>>>>.>>.....>>>>>>.......<......<<<<<<.......>>>>>><<<<....<<<<..<<..<<<<<<<...<<.....>>.>>>>>>>...((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<.....<.<.....<<<<..<<<..<<<<<.<<<<.<<...[[[...>>>>>><.....<<<..<...<<<<<<..<.......>.>>>>>>.......>.>>>.....><.....<<<....>>>......>>>>>>...>>>...>>>>..........>.>........>>>>>>>>>>>>>>>..>>.....<<......>>.>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.<<<........>>>..>>>>>>............<<<<<<<<<..<<<<.......>>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>....................<<<<<<.....>>>>>>..........>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>.>...........<<<<<........>>>>>..<<<<<<<<.<<<.<<......<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<......>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<..<<<<<<<...<<.......>>...>>>>>>>...>>>.>.......<.<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>......>>>..>....<<<<<<<....>>>.>>>>....>>..>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]].>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>....<<.....>>......<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>>> ((((((((......(((((((((((....(((..((((((((((.(......(((((((....[[)))).....((((((...(((]].....)))......))))))...)))....(((....)))((((((((....)))))))).(((..........))).)....((((((.....(......)......)))))..)........((....))...(((((.....((.....))....)))))..((((....((((((((.....))))))))......((((((((.....((...((((((.(((..(((...(((((......)))))[[(...).(((.....]])))...)))....)))..))))))..)).))))).))).....(((((((((.......)))))))))......((((((.[[.))))))..)))).....)).)))))).))...............((....))....)).........((((....)))).............)....))))))))))).......(((((((((((....)))))))))))...(............).((((((....(((((((((((((..((....(.(.....).)....))...((....))...(((.....)))......)))))))))))))..((.(...((((((...((((((((((((.((((...((((((......))))))....))))...(((..((((........)))).)))..).))))))))))).(((.....)))......))))))......).))..((((((....(((((....))))).((((((((.(.(.(((((((((.(.(((...((((((((...((((((......)))).))...))))))))..)).).).))))))))).).).))))))).)...(((((((.((......)).))))))).....(((......)))...((((.(((...(((.[....(.(((((((..........((..((((((((((.......((.((.(((..(((.........)))..)))(...)(...((......)).).)).))...)))))))))).))...........].......)))))))))))...)))))))((((((((.....))))))))....))))))..(((((...(((......(((((.(......).)))))...)))..)))))........)))))).......((.....((((((.......))))))((((....((((..(...(((((((...((.....)).)))))))...[[(((..((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((.....((((....((((..(((..(((((.((((.((.........))))))(((...((...(((((((((((.((.....)))))))))).....))).))....))).(..((((....))))..)...)))))...)))...)))).........))))........))))))))))).)))...).....((......)).)))).((((......))))..))))..((((....((((((((.(((...............((((....(....).....)))).((((((.(.(.........).).))))))(...).......(((((((((..(((((.....)))))..(((((((.....(((....))).......)))))))..((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))((((((.......))))))....................((((((.....))))))..........))))...)).)))))))....))).)))))))).))))))........[..(((((......].)))))..((((((((.(((.((......((((.((((((..(((((.(((.((((..((((((((((((((((.(......[..(((((..((((.....((((((((....))))))))..))))..........].)))))).))))))))))))))))...(((((....))))).....)))).)))..)))))..((((.....))))((((((...........))))))([((...(((((((.(.((((((.......))))))...).((][.[..))....)))))))...((((..(((......)))..)))).(((....))).))..].].....(((((((.((....]]..))))))))).....).......))))..))))))........(((.((((((((...((.......))...))))))))..)))..........((((.((((((..(((((((((......)))))))..)).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....))..)))))))))))....((((((((..((((..(((((((...(.(....).)..))))))).(((((...(((....(((((((((((....))))))...)))))....))).)))))...(((....(((((...........)))))....))).))))......))))))))..(.((.....)).)....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))....)))))))) Crystal structure of the 70S Thermus thermophilus ribosome with translocated and rotated Shine-Dalgarno Duplex.; 23S ribosomal RNA 4v4y BB 123 5.5 RF00001 URS00001170B4_300852 17051149 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcgggggau ..<<<<<<<<<<<....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>..>....>>>.>>>>>>>>>>>. ..(((((((((((....((((((((.....((((((.............))))..))....)))))).)).((.......((((((((....)))))))).......))..))))))))))). Crystal structure of the 70S Thermus thermophilus ribosome with translocated and rotated Shine-Dalgarno Duplex.; 5S ribosomal RNA 4v4z AA 1515 4.51 RF00177,RF01959,RF01960 URS000080E226_300852 17051149 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucaccuccuuu ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<.......>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<............>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<((....<<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<(......<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<....<<<......>>>.......>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<...)>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<<....>>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<...<<<.....>>>.>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>.......<<...<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>....>>.........<<<<<<<<<....>>>>>>>>>.............. ....(((((.[.[[[.))))).((((.(((((..((((((.((....(((.(((..(((..((.(((((((((((...))))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)..))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........(((.......((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((...(((((((....(((......))).......)))))))...).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))..........((((((..((((((((((...))))))))))...((....)).....)))))).))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((.....(((........))).......(.(((((((......((((((((..(((((((....))))))).(.((((....)))).)))))))))..((.(((...((((((.((...(((((((((....)))..((((......))))..)))))).....((((.(((((((..(.(..(((.....)))).)...))))))).....(((((....)))))........))))....)).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))....(..((...((((.(((...((((((((((((...(.((((....(((....))).)))).)..))))))))))))...))).))))....))...).....(((((((((....))))))))).............. 70S Thermus thermophilous ribosome functional complex with mRNA and E- and P-site tRNAs at 4.5A.; 16S rRNA 4v4z AC 76 4.51 RF00005 URS000080DFF5_562 17051149 0030533 0006412 562 cgcgggguggagcagccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.....[..)))).(((((.......))))).....(((((..]....)))))))))))..... 70S Thermus thermophilous ribosome functional complex with mRNA and E- and P-site tRNAs at 4.5A.; tRNA fMET (unmodified bases) 4v4z AD 76 4.51 RF00005 URS000080DFDE_300852 17051149 0030533 0006412 300852 gccgagguagcucaguugguagagcaugcgacugaaaaucgcagugucggcgguucgauuccgcuccucggcacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((........)))).(((((.......))))).....(((((.......)))))))))))).... 70S Thermus thermophilous ribosome functional complex with mRNA and E- and P-site tRNAs at 4.5A.; tRNA PHE (unmodified bases) 4v4z A1 27 4.51 17051149 ggcaaggagguaaaaaugaaaaaaaaa ........................... ........................... 70S Thermus thermophilous ribosome functional complex with mRNA and E- and P-site tRNAs at 4.5A.; mRNA 4v4z BA 2889 4.51 RF02540,RF02541,RF00002 URS000080E1D6_300852 17051149 0003735 0005840 300852 ggucaagaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaugcggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgaggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucuugacc <<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<..........>>>.>>....<<<<<.....<......>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<............<<<<<..<<..<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>....>>...>>>>>.......>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<...<.....<......>.....>.....<<....>>...<<......>>.......>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<....<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.....>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<........>>...<<<<.<<<...<<<((......<<<<<<<..........<<..<<<<<<<<.........<<<<<.<<.....................>>.........<........>...>>>>>.....>>>>>>>>.>>...........))......>>>>>>>.>>>...>>>>>>><<.<<<<.......>>>>.>>....>>>>>><<<<<<<...<<<......<<<<<.<......>.>>>>>...>>>..>>>>>.>>.....>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<..<<<<<<<...<<.....>>.>>>>>>>...((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<.....<<<.....<<<<..<<<..<<<<<.<<<<.<<...[[[...>>>>>><.....<<<..<<..<<<<<<..<.......>.>>>>>>......>>.>>>.....>......<<<....>>>.......>>>>>...>>>...>>>>.........>>.>........>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.<<<........>>>..>>>>>>............<<<<<<<<<..<<<<.......>>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>....................<<<<<<.....>>>>>>..........>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.<<<.<<......<<<<.<<<<<<..<<<<<.<<<.<<<<..<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<<..>>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<......>>>>.....>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<..<<<<<<<...<<.......>>...>>>>>>>...>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]].>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<.<.....>>......<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>>> ((((((((......(((((((((((....(((..((((((((((((......(((((((....[[)))).....((((((...(((]].....)))......))))))...)))....(((....)))((((((((....))))))))..(............)..))....(((((.....(...[..)......)))))...........((....))...(((((.....((.]...))....)))))..((((....((((((((.....))))))))......((((((((.....((....(((((.(((..(((...(((((......)))))[[(...).(((.....]])))...)))....)))..)))))...)).))))).))).....(((((((((.......)))))))))......((((((.[[.))))))..)))).....)).)))))).))...............((....))....))......(..((((....))))............))....))))))))))).......(((((((((((....)))))))))))...(.(........).).((((((....(((((((((((((..((.(....(.....)....).))...((....))..(.((.....)).).....)))))))))))))..((.(...((((((...((((((((((((.((((...((((((......))))))....))))...(((..((((.......<)))).)))..).))))))))))).(((.....)))......))))))......).))..((((((....(((((....))))).((((((((.(.(.(((((((((...(((...((((((((...((((((......)))).))...))))))))..)).)...))))))))).).).))))))).)...(((((((.((......)).))))))).....(((......)))...((((.(((...((([[....(.(((((((..........((..((((((((.(.......((.((.(((..(((.........)))..)))(...)(...((......)).).)).))...).)))))))).))...........]]......)))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(......).)))))...)))..)))))..).....)))))).......((.....((((((.......))))))((((....((((..(...(((((((...((.....)).)))))))...[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((.....((((....((((..(((..(((((.((((.((...{.....))))))(.(...((...(((((((((((.((.....)))))))))).....))).))....).).(..((((....))))..)...)))))...)))...)))).........))))........)))))))))))))))...).....((......)).)))).(((((....)))))..))))..((((....((((((((.((.......(........((((....(.[..).....)))).((((((((.(.........).))))))))(...).......(((((((((..(((((.....)))))..(((((((.(...(((.(.))))...)...))))))).]((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))((((((.......))))))....................((((((.....))))))..........))))...)).)))))))..)..)).)))))))).))))))........[..(((((......].)))))..((((((((.(((.((......((((.((((((..(((((.(((.((((..((((((((((((((((.(......[..(((((..((((.....((((((((....))))))))..))))..........].)))))).))))))))))))))))...(((((....))))).....)))).)))..)))))..((((.....))))((((((...........)))))).[((...(((((((.(.((((((.......))))))...).((]..[[.))....)))))))...((((..(((......)))..)))).(((....))).)).]].......(((((((.((....]]..))))))))).............))))..)))))).......((((.((((((((...((.......))...))))))))..))).)........((((.((((((..(((((((((......)))))))..)).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.))..)))))))))))....((((((((..((((..(((((((...(.(....).)..))))))).(((((...(((....(((((((((((..}.))))))...)))))....))).)))))...(((....(((((...........)))))....))).))))......))))))))...(((.....))).....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))....)))))))) 70S Thermus thermophilous ribosome functional complex with mRNA and E- and P-site tRNAs at 4.5A.; 23S rRNA 4v4z BB 123 4.51 RF00001 URS00001170B4_300852 17051149 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcgggggau ..<<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>>>. ..(((((((((((....((((((((.....((((((.............))))..))....)))))).)).((.......((((((((....)))))))).......))..))))))))))). 70S Thermus thermophilous ribosome functional complex with mRNA and E- and P-site tRNAs at 4.5A.; 5S rRNA 4v50 AA 1530 3.22 RF00177,RF01959,RF01960 URS00000ABFE9_562 17038497 0003735 0005840 562 ugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggauca ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<..<..>..>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>...<.<<<<<......<.<<<<<<.<.......>>>.>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<..<.<<<<<<<........>>>>>>>>...>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((((((((..)))))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(...(((((((.(.......))).)))).)...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))...((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.....]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Crystal Structure of Ribosome with messenger RNA and the Anticodon stem-loop of P-site tRNA.; 16S ribosomal RNA 4v50 AW 17 3.22 URS000080E2A3_32630 17038497 32630 ucgggcucauaacccga <<<<<.......>>>>> (((((.......))))) Crystal Structure of Ribosome with messenger RNA and the Anticodon stem-loop of P-site tRNA.; PHE TRNA (UNMODIFIED BASES) 4v50 BA 117 3.22 RF00001 URS0000049E57_562 17038497 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggc <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>> (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))) Crystal Structure of Ribosome with messenger RNA and the Anticodon stem-loop of P-site tRNA.; 5S ribosomal RNA 4v50 BB 2841 3.22 RF02540,RF02541 URS00004B0F34_562 17038497 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaacaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauggaaguguggacgccagucugcauggcuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<.......>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<.....<<<<<<<......>>>>>>>....>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<<...>>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((...(((((((((.(...(((...(((.((((.......)))).)))..)).)...).)))))).)))...))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((..((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((((((((((...((((....((((..(((..(((((((((((....{{{...))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((((.(...((((((((....))))))))..).)))).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..(....)..]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((...))))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Crystal Structure of Ribosome with messenger RNA and the Anticodon stem-loop of P-site tRNA.; 23S ribosomal RNA 4v50 CA 1530 3.22 RF00177,RF01959,RF01960 URS00000ABFE9_562 17038497 0003735 0005840 562 ugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggauca ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<......>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>...<.<<<<<......<.<<<<<<.<.......>>>.>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<..<.<<<<<<<........>>>>>>>>...>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((((((((..)))))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(...(((((((.(.......))).)))).)...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))...((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.....]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Crystal Structure of Ribosome with messenger RNA and the Anticodon stem-loop of P-site tRNA.; 16S ribosomal RNA 4v50 CW 17 3.22 URS000080E2A3_32630 17038497 32630 ucgggcucauaacccga <<<<<.......>>>>> (((((.......))))) Crystal Structure of Ribosome with messenger RNA and the Anticodon stem-loop of P-site tRNA.; PHE TRNA (UNMODIFIED BASES) 4v50 DA 117 3.22 RF00001 URS0000049E57_562 17038497 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggc <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>> (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))) Crystal Structure of Ribosome with messenger RNA and the Anticodon stem-loop of P-site tRNA.; 5S ribosomal RNA 4v50 DB 2841 3.22 RF02540,RF02541 URS00004B0F34_562 17038497 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaacaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauggaaguguggacgccagucugcauggcuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<.......>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<.....<<<<<<<......>>>>>>>...>.>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<<...>>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((...(((((((((.(...(((...(((.((((.......)))).)))..)).)...).)))))).)))...))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((..((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((((((((((...((((....((((..(((..(((((((((((....{{{...))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((((.(...(((((((......)))))))..).)))).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..(....)..]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((...))))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Crystal Structure of Ribosome with messenger RNA and the Anticodon stem-loop of P-site tRNA.; 23S ribosomal RNA 4v51 AA 1504 2.8 RF00177,RF01959,RF01960 URS000080E226_300852 16959973 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<...<........>..>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<.<<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<.<...<<<<<<<....>>>>>>>...<<<<....>>>>....>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<....<<.....>>..>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<...<<<<....>>>>...>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.((...(((..((.((((..(...........)..)))).)))))......(((......((((((((..((...(((((((.(((((....(((..(....)..))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))....))))).).....(.(((...(.(.(....).)..))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((....((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..)))....))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((.(..((((((((((......((........))..........(((((((..(...(((((.....(((((((....)))))))....................)))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(.(((((........................))))).)..(..((..(....)..)).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..).))).....(((((((..........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Structure of the Thermus thermophilus 70S ribosome complexed with mRNA, tRNA and paromomycin; 16S ribosomal RNA 4v51 AV 77 2.8 RF00005 URS000041AF00_83333 16959973 0030533 0006412 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((.]....)))))))))))..... Structure of the Thermus thermophilus 70S ribosome complexed with mRNA, tRNA and paromomycin; P-SITE TRNA FMET (UNMODIFIED BASES EXCEPT FOR THYMINE 54) 4v51 AW 76 2.8 RF00005 URS00005AA258_83333 16959973 0030533 0006412 83333 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((........)))).((((.........)))).....(((((.......)))))))))))).... Structure of the Thermus thermophilus 70S ribosome complexed with mRNA, tRNA and paromomycin; E-SITE TRNA PHE OR A-SITE TRNA PHE (UNMODIFIED BASES) 4v51 AX 11 2.8 16959973 32630 aaaaauguuca ........... ........... Structure of the Thermus thermophilus 70S ribosome complexed with mRNA, tRNA and paromomycin; MRNA 4v51 AY 19 2.8 RF00005 URS00005AA258_83333 16959973 0030533 0006412 83333 aggggauugaaaauccccg .<<<<<<.....>>>>>>. ..(.((.......)).).. Structure of the Thermus thermophilus 70S ribosome complexed with mRNA, tRNA and paromomycin; E-SITE TRNA PHE OR A-SITE TRNA PHE (UNMODIFIED BASES) 4v51 BA 2772 2.8 RF02540,RF02541,RF00002 URS000080E25D_300852 16959973 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucgggggcccucggccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcgccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccagucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccuggcgccggugaaauccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<..>>>>>>.>>....<<<<<.....<<....>>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>.....<<<<<<<<.<.<<...<<<.<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>...>>>>..>>>.>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<....>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<...<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<.....<<....>>......>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<....>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>>.............>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<<..................>>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<<..<<.......>>>..>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<.......>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> ((.......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((....))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....((((.(((((...(....((.(.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..).))...)..)))))..)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((((((((....)))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))..)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((.(....(....)....)..))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((((((..................))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.((...{{....))))))(((...(((((((((..(((((.((.....))))))).......)))))))))..)))(...........))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((.........))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((.(.((((.(.........(((((...(...)............)))))).)))).).)))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))...(.........).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...)))).....)) Structure of the Thermus thermophilus 70S ribosome complexed with mRNA, tRNA and paromomycin; 23S RIBOSOMAL RNA 4v51 BB 119 2.8 RF00001 URS00005F2F4B_300852 16959973 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<<....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>> .((((((((((....(((((.((....(((.(((...(.....)...)))...)))...)).))).))(((.......((.(((((....))))).)).......))).)))))))))) Structure of the Thermus thermophilus 70S ribosome complexed with mRNA, tRNA and paromomycin; 5S RIBOSOMAL RNA 4v51 CA 1504 2.8 RF00177,RF01959,RF01960 URS000080E226_300852 16959973 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<...<........>..>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<.<<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<.<...<<<<<<<....>>>>>>>...<<<<....>>>>....>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<....<<.....>>..>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<...<<<<....>>>>...>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<<..>>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.((...(((..((.((((..(...........)..)))).)))))......(((......((((((((..((...(((((((.(((((....(((..(....)..))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))....))))).).....(.(((...(.(.(....).)..))))).)).))))))..((((......((((....)))).....))))....(((((...(....(((.......))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((....((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..)))....))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((.(..((((((((((......((........))..........(((((((..(...(((((.....(((((((....)))))))....................)))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(.(((((........................))))).)..(..((..(....)..)).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..).))).....(((((((..........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Structure of the Thermus thermophilus 70S ribosome complexed with mRNA, tRNA and paromomycin; 16S ribosomal RNA 4v51 CV 77 2.8 RF00005 URS000041AF00_83333 16959973 0030533 0006412 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>......<<<<.......>>>>.>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((.]....)))))))))))..... Structure of the Thermus thermophilus 70S ribosome complexed with mRNA, tRNA and paromomycin; P-SITE TRNA FMET (UNMODIFIED BASES EXCEPT FOR THYMINE 54) 4v51 CW 76 2.8 RF00005 URS00005AA258_83333 16959973 0030533 0006412 83333 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((........)))).((((.........)))).....((.(.........).))))))))).... Structure of the Thermus thermophilus 70S ribosome complexed with mRNA, tRNA and paromomycin; E-SITE TRNA PHE OR A-SITE TRNA PHE (UNMODIFIED BASES) 4v51 CX 11 2.8 16959973 32630 aaaaauguuca ........... ........... Structure of the Thermus thermophilus 70S ribosome complexed with mRNA, tRNA and paromomycin; MRNA 4v51 CY 19 2.8 RF00005 URS00005AA258_83333 16959973 0030533 0006412 83333 aggggauugaaaauccccg .<<<<<<.....>>>>>>. ..((((.......)))).. Structure of the Thermus thermophilus 70S ribosome complexed with mRNA, tRNA and paromomycin; E-SITE TRNA PHE OR A-SITE TRNA PHE (UNMODIFIED BASES) 4v51 DA 2772 2.8 RF02540,RF02541,RF00002 URS000080E25D_300852 16959973 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucgggggcccucggccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcgccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccagucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccuggcgccggugaaauccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<..>>>>>>.>>....<<<<<.....<<....>>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>.....<<<<<<<<.<.<<...<<<.<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>...>>>>..>>>.>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<....>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<...<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<.....<<....>>......>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<....>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>>.............>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<<..................>>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<<..<<.......>>>..>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<.......>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> ((.......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((....))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....((((.(((((...(....((.(.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..).))...)..)))))..)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((((((((....)))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))..)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((.(....(....)....)..))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((((((..................))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.((...{{....))))))(((...(((((((((..(((((.((.....))))))).......)))))))))..)))(...........))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((.........))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((.(.((((...........(((((...(...)............)))))..)))).).)))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))...(.........).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...)))).....)) Structure of the Thermus thermophilus 70S ribosome complexed with mRNA, tRNA and paromomycin; 23S RIBOSOMAL RNA 4v51 DB 119 2.8 RF00001 URS00005F2F4B_300852 16959973 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<<....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>> .((((((((((....(((((.((....(((.(((...(.....)...)))...)))...)).))).))(((.......((.(((((....))))).)).......))).)))))))))) Structure of the Thermus thermophilus 70S ribosome complexed with mRNA, tRNA and paromomycin; 5S RIBOSOMAL RNA 4v52 AA 1530 3.21 RF00177,RF01959,RF01960 URS00000ABFE9_562 17660832 0003735 0005840 562 ugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggauca ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<<....>>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>...<.<<<<<......<.<<<<<<.<.<...>.>>>.>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((((((((..)))))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(...(((((((.(.......))).)))).)...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((..(((((((....)))))))...((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.....]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Crystal structure of the bacterial ribosome from Escherichia coli in complex with neomycin.; 16S rRNA 4v52 BA 117 3.21 RF00001 URS0000049E57_562 17660832 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggc <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>> (((((((((.....((((((((.....((((((...(.....)...))))..))....)))))).)).((.......((((((((...)))))))).......))...))))))))) Crystal structure of the bacterial ribosome from Escherichia coli in complex with neomycin.; 5S rRNA 4v52 BB 2841 3.21 RF02540,RF02541 URS00004B0F34_562 17660832 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaacaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauggaaguguggacgccagucugcauggcuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.<...<<<...<<<.<<<<.......>>>>.>>>..>>.>...>.>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<.....<<<<<<<<....>>>>>>>>....>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>.(<<...<<<<<<<...<<<<<<.......>>>>>>.....<<)..(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<<...>>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((...(((((((((.(...(((...(((.((((.......)))).)))..)).)...).)))))).)))...))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.......(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((..((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((.....{{{....)))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((((.(...((((((((....))))))))..).)))).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..(....)..]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.((((((...))))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Crystal structure of the bacterial ribosome from Escherichia coli in complex with neomycin.; 23S rRNA 4v52 CA 1530 3.21 RF00177,RF01959,RF01960 URS00000ABFE9_562 17660832 0003735 0005840 562 ugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggauca ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<<<..>>>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>...<.<<<<<......<.<<<<<<.<.<...>.>>>.>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((((((((..)))))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(...(((((((.(.......))).)))).)...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((..(((((((....)))))))...((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.....]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Crystal structure of the bacterial ribosome from Escherichia coli in complex with neomycin.; 16S rRNA 4v52 DA 117 3.21 RF00001 URS0000049E57_562 17660832 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggc <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>> (((((((((.....((((((((.....((((((...(.....)...))))..))....)))))).)).((.......((((((((...)))))))).......))...))))))))) Crystal structure of the bacterial ribosome from Escherichia coli in complex with neomycin.; 5S rRNA 4v52 DB 2841 3.21 RF02540,RF02541 URS00004B0F34_562 17660832 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaacaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauggaaguguggacgccagucugcauggcuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.<...<<<...<<<.<<<<.......>>>>.>>>..>>.>...>.>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<......<<<<<<<......>>>>>>>.....>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>.(<<...<<<<<<<...<<<<<<.......>>>>>>.....<<)..(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<<...>>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((...(((((((((.(...(((...(((.((((.......)))).)))..)).)...).)))))).)))...))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((..((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((.....{{{....)))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((((.(...(((((((......)))))))..).)))).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..(....)..]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((...))))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Crystal structure of the bacterial ribosome from Escherichia coli in complex with neomycin.; 23S rRNA 4v53 AA 1530 3.54 RF00177,RF01959,RF01960 URS00000ABFE9_562 17660832 0003735 0005840 562 ugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggauca ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<.<<..>>.>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<.<.......>>>.>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((((((((..)))))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(...(((((((.(.......))).)))).)...)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))...((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.....]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Crystal structure of the bacterial ribosome from Escherichia coli in complex with gentamicin.; 16S rRNA 4v53 BA 117 3.54 RF00001 URS0000049E57_562 17660832 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggc <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>> (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))) Crystal structure of the bacterial ribosome from Escherichia coli in complex with gentamicin.; 5S rRNA 4v53 BB 2841 3.54 RF02540,RF02541 URS00004B0F34_562 17660832 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaacaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauggaaguguggacgccagucugcauggcuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.<...<<<...<<<.<<<<.......>>>>.>>>..>>.>...>.>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<..<<....>>...>>>>>..>....>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<.....<<<<<<<<....>>>>>>>>....>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<<...>>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((...(((((((((.(...(((...(((.((((.......)))).)))..)).)...).)))))).)))...))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.......(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((..((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((.....{{{....)))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((((.(...(((((((......)))))))..).)))).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.((((((...))))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Crystal structure of the bacterial ribosome from Escherichia coli in complex with gentamicin.; 23S rRNA 4v53 CA 1530 3.54 RF00177,RF01959,RF01960 URS00000ABFE9_562 17660832 0003735 0005840 562 ugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggauca ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<<<..>>>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<.<.......>>>.>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((((((((..)))))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(...(((((((.(.......))).)))).)...)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))...((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.....]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Crystal structure of the bacterial ribosome from Escherichia coli in complex with gentamicin.; 16S rRNA 4v53 DA 117 3.54 RF00001 URS0000049E57_562 17660832 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggc <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>> (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))) Crystal structure of the bacterial ribosome from Escherichia coli in complex with gentamicin.; 5S rRNA 4v53 DB 2841 3.54 RF02540,RF02541 URS00004B0F34_562 17660832 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaacaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauggaaguguggacgccagucugcauggcuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.<...<<<...<<<.<<<<.......>>>>.>>>..>>.>...>.>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<..<<....>>...>>>>>..>....>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<......<<<<<<<......>>>>>>>.....>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<<...>>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((...(((((((((.(...(((...(((.((((.......)))).)))..)).)...).)))))).)))...))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((..((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((.....{{{....)))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((((.(...(((((((......)))))))..).)))).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((...))))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Crystal structure of the bacterial ribosome from Escherichia coli in complex with gentamicin.; 23S rRNA 4v54 AA 1530 3.3 RF00177,RF01959,RF01960 URS00000ABFE9_562 17660832 0003735 0005840 562 ugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggauca ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<<....>>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<.<.......>>>.>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((((((((..)))))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(...(((((((.(.......))).)))).)...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))...((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.....]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Crystal structure of the bacterial ribosome from Escherichia coli in complex with ribosome recycling factor (RRF).; 16S rRNA 4v54 BA 117 3.3 RF00001 URS0000049E57_562 17660832 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggc <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>> (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))) Crystal structure of the bacterial ribosome from Escherichia coli in complex with ribosome recycling factor (RRF).; 5S rRNA 4v54 BB 2841 3.3 RF02540,RF02541 URS00004B0F34_562 17660832 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaacaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauggaaguguggacgccagucugcauggcuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.<...<<<...<<<.<<<<.......>>>>.>>>..>>.>...>.>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<......<.<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>.>..>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<<..>>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<..<<....>>...>>>>>..>....>>>>>>>>>..>>>>><<<.<.........>.>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<......<<<<<<<......>>>>>>>.....>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>.(<<...<<<<<<<...<<<<<<.......>>>>>>.....<<)..(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<<...>>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((...(((((((((.(...(((...(((.((((.......)))).)))..)).)...).)))))).)))...))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.......(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((..((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((.....{{{....)))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((((.(...(((((((......)))))))..).)))).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.((((((...))))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Crystal structure of the bacterial ribosome from Escherichia coli in complex with ribosome recycling factor (RRF).; 23S rRNA 4v54 CA 1530 3.3 RF00177,RF01959,RF01960 URS00000ABFE9_562 17660832 0003735 0005840 562 ugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggauca ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<<<..>>>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<.<.......>>>.>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((((((((..)))))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(...(((((((.(.......))).)))).)...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))...((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.....]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Crystal structure of the bacterial ribosome from Escherichia coli in complex with ribosome recycling factor (RRF).; 16S rRNA 4v54 DA 117 3.3 RF00001 URS0000049E57_562 17660832 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggc <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>> (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))) Crystal structure of the bacterial ribosome from Escherichia coli in complex with ribosome recycling factor (RRF).; 5S rRNA 4v54 DB 2841 3.3 RF02540,RF02541 URS00004B0F34_562 17660832 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaacaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauggaaguguggacgccagucugcauggcuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.<...<<<...<<<.<<<<.......>>>>.>>>..>>.>...>.>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<<..>>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<..<<....>>...>>>>>..>....>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<......<<<<<<<......>>>>>>>.....>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>.(<<...<<<<<<<...<<<<<<.......>>>>>>.....<<)..(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<<...>>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((...(((((((((.(...(((...(((.((((.......)))).)))..)).)...).)))))).)))...))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((..((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((.....{{{....)))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((((.(...(((((((......)))))))..).)))).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((...))))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Crystal structure of the bacterial ribosome from Escherichia coli in complex with ribosome recycling factor (RRF).; 23S rRNA 4v55 AA 1530 4.0 RF00177,RF01959,RF01960 URS00000ABFE9_562 17660832 0003735 0005840 562 ugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggauca ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<.<<..>>.>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<.<.......>>>.>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((((((((..)))))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(...(((((((.(.......))).)))).)...)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))...((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.....]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Crystal structure of the bacterial ribosome from Escherichia coli in complex with gentamicin and ribosome recycling factor (RRF).; 16S rRNA 4v55 BA 117 4.0 RF00001 URS0000049E57_562 17660832 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggc <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>> (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))) Crystal structure of the bacterial ribosome from Escherichia coli in complex with gentamicin and ribosome recycling factor (RRF).; 5S rRNA 4v55 BB 2841 4.0 RF02540,RF02541 URS00004B0F34_562 17660832 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaacaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauggaaguguggacgccagucugcauggcuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.<...<<<...<<<.<<<<.......>>>>.>>>..>>.>...>.>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<.....<<<<<<<<....>>>>>>>>....>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<<...>>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((...(((((((((.(...(((...(((.((((.......)))).)))..)).)...).)))))).)))...))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.......(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((..((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((.....{{{....)))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((((.(...((((((((....))))))))..).)))).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.((((((...))))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Crystal structure of the bacterial ribosome from Escherichia coli in complex with gentamicin and ribosome recycling factor (RRF).; 23S rRNA 4v55 CA 1530 4.0 RF00177,RF01959,RF01960 URS00000ABFE9_562 17660832 0003735 0005840 562 ugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggauca ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<<<..>>>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<.<.......>>>.>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((((((((..)))))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(...(((((((.(.......))).)))).)...)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))...((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.....]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Crystal structure of the bacterial ribosome from Escherichia coli in complex with gentamicin and ribosome recycling factor (RRF).; 16S rRNA 4v55 DA 117 4.0 RF00001 URS0000049E57_562 17660832 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggc <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>> (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))) Crystal structure of the bacterial ribosome from Escherichia coli in complex with gentamicin and ribosome recycling factor (RRF).; 5S rRNA 4v55 DB 2841 4.0 RF02540,RF02541 URS00004B0F34_562 17660832 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaacaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauggaaguguggacgccagucugcauggcuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.<...<<<...<<<.<<<<.......>>>>.>>>..>>.>...>.>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<......<<<<<<<<....>>>>>>>>.....>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>.(<<...<<<<<<<...<<<<<<.......>>>>>>.....<<)..(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<<...>>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((...(((((((((.(...(((...(((.((((.......)))).)))..)).)...).)))))).)))...))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.......(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((..((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((.....{{{....)))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((((.(...(((((((......)))))))..).)))).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.((((((...))))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Crystal structure of the bacterial ribosome from Escherichia coli in complex with gentamicin and ribosome recycling factor (RRF).; 23S rRNA 4v56 AA 1530 3.93 RF00177,RF01959,RF01960 URS00000ABFE9_562 17696316 0003735 0005840 562 ugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggauca ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<.<....>.>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>...<.<<<<<......<.<<<<<<.<.......>>.>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((((((((..)))))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(...(((((((.(.......))).)))).)...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))...((....))..))))).))).((.(((...((((((......(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).......).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.....]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Crystal structure of the bacterial ribosome from Escherichia coli in complex with spectinomycin.; 16S rRNA 4v56 BA 117 3.93 RF00001 URS0000049E57_562 17696316 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggc <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>> (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))) Crystal structure of the bacterial ribosome from Escherichia coli in complex with spectinomycin.; 5S rRNA 4v56 BB 2841 3.93 RF02540,RF02541 URS00004B0F34_562 17696316 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaacaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauggaaguguggacgccagucugcauggcuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.<...<<<...<<<.<<<<.......>>>>.>>>..>>.>...>.>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<<..>>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<.....<<<<<<<<....>>>>>>>>....>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>.(<<...<<<<<<<...<<<<<<.......>>>>>>.....<<)..(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<<...>>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((...(((((((((.(...(((...(((.((((.......)))).)))..)).)...).)))))).)))...))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.......(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((..((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....((((..(((..(((((((((((....{{{...))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((((.(...(((((((......)))))))..).)))).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..(....)..]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.((((((...))))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Crystal structure of the bacterial ribosome from Escherichia coli in complex with spectinomycin.; 23S rRNA 4v56 CA 1530 3.93 RF00177,RF01959,RF01960 URS00000ABFE9_562 17696316 0003735 0005840 562 ugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggauca ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<<<..>>>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>...<.<<<<<......<.<<<<<<.<.......>>.>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((((((((..)))))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(...(((((((.(.......))).)))).)...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))...((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.....]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Crystal structure of the bacterial ribosome from Escherichia coli in complex with spectinomycin.; 16S rRNA 4v56 DA 117 3.93 RF00001 URS0000049E57_562 17696316 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggc <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>> (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))) Crystal structure of the bacterial ribosome from Escherichia coli in complex with spectinomycin.; 5S rRNA 4v56 DB 2841 3.93 RF02540,RF02541 URS00004B0F34_562 17696316 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaacaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauggaaguguggacgccagucugcauggcuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.<...<<<...<<<.<<<<.......>>>>.>>>..>>.>...>.>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<<..>>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<......<<<<<<<......>>>>>>>.....>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>.(<<...<<<<<<<...<<<<<<.......>>>>>>.....<<)..(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<<...>>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((...(((((((((.(...(((...(((.((((.......)))).)))..)).)...).)))))).)))...))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((..((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((((((((((...((((....((((..(((..(((((((((((....{{{...))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((((.(...(((((((......)))))))..).)))).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..(....)..]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((...))))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Crystal structure of the bacterial ribosome from Escherichia coli in complex with spectinomycin.; 23S rRNA 4v57 AA 1530 3.5 RF00177,RF01959,RF01960 URS00000ABFE9_562 17696316 0003735 0005840 562 ugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggauca ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<.<....>.>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<<..>>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<.<.......>>.>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((((((((..)))))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(...(((((((.(.......))).)))).)...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))...((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.....]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Crystal structure of the bacterial ribosome from Escherichia coli in complex with spectinomycin and neomycin.; 16S rRNA 4v57 BA 117 3.5 RF00001 URS0000049E57_562 17696316 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggc <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>> (((((((((.....((((((((.....((((((...(.....)...))))..))....)))))).)).((.......((((((((...)))))))).......))...))))))))) Crystal structure of the bacterial ribosome from Escherichia coli in complex with spectinomycin and neomycin.; 5S rRNA 4v57 BB 2841 3.5 RF02540,RF02541 URS00004B0F34_562 17696316 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaacaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauggaaguguggacgccagucugcauggcuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.<...<<<...<<<.<<<<.......>>>>.>>>..>>.>...>.>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<.....<<<<<<<......>>>>>>>....>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<<...>>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((...(((((((((.(...(((...(((.((((.......)))).)))..)).)...).)))))).)))...))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.......(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((..((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((.....{{{....)))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((((.(...((((((((....))))))))..).)))).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..(....)..]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.((((((...))))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Crystal structure of the bacterial ribosome from Escherichia coli in complex with spectinomycin and neomycin.; 23S rRNA 4v57 CA 1530 3.5 RF00177,RF01959,RF01960 URS00000ABFE9_562 17696316 0003735 0005840 562 ugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggauca ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<<<..>>>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<<..>>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<.<.......>>.>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<..<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>.........>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((((((((..)))))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(...(((((((.(.......))).)))).)...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))...((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.....]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Crystal structure of the bacterial ribosome from Escherichia coli in complex with spectinomycin and neomycin.; 16S rRNA 4v57 DA 117 3.5 RF00001 URS0000049E57_562 17696316 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggc <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>> (((((((((.....((((((((.....((((((...(.....)...))))..))....)))))).)).((.......((((((((...)))))))).......))...))))))))) Crystal structure of the bacterial ribosome from Escherichia coli in complex with spectinomycin and neomycin.; 5S rRNA 4v57 DB 2841 3.5 RF02540,RF02541 URS00004B0F34_562 17696316 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaacaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauggaaguguggacgccagucugcauggcuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<.<....<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>..>>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.<...<<<...<<<.<<<<.......>>>>.>>>..>>.>...>.>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<......<<<<<<<......>>>>>>>.....>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<<...>>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((...(((((((((.(...(((...(((.((((.......)))).)))..)).)...).)))))).)))...))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((..((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((.....{{{....)))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((((.(...(((((((......)))))))..).)))).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..(....)..]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((...))))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Crystal structure of the bacterial ribosome from Escherichia coli in complex with spectinomycin and neomycin.; 23S rRNA 4v5a AA 1504 3.5 RF00177,RF01959,RF01960 URS000080E226_300852 17660830 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<.........>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<...<<<<<<......>>>>>.>...>>>>>....<<<<.<<<<<....>>>>>.>>>>...<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<........<<<.......>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>....<<.....>>....>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<....<.......>..>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((..(...(((..((.((((..(...........)..)))).)))))......(((......((((((((..((...(((((((.(((((....((((.(....).)))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((...(((((((.......))))))).)))......)))..((((((((....))))...))))))).(((.(............).))).((((....))))....).))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....((((....(....((.(......))).....).....))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.(((((((.((......((((((.....))))))....)).)))))..)))))))))..(((.(((((...((((((((....((((((....((........)).......))))))....).......(......).)))))))..)))))..))..))))...))))....(((((....((....(.............)....)).)))))......{...((((((..(..(((..((...))..)))..)...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((....((((((((((......((........))..........(((((((..(...((........((...((....).)..)).......................))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.((((.((..(.................)...)).))))..(...((.(....).))......)..)))).....).).)))...)).)))).)...)))))))..[)).)))))))).(...(((((((.....((....(..((((....))))..)......)).....)))))))...........(((((((........))))))).......)....))).....(.(((((......]...))))).)......))...)))))))))).))..(.(..((.(.((((.(((..(.((.((((((((.....((((......(....)...))))....)))))))).)).)..))).))))..).))...)..)..(((((.(((....))).)))))}.. Structure of the Ribosome Recycling Factor bound to the Thermus thermophilus 70S ribosome with mRNA, ASL-Phe and tRNA-fMet; 16S ribosomal RNA 4v5a AV 17 3.5 RF00005 URS00005AA258_32630 17660830 0030533 0006412 32630 ggggauugaaaaucccc <<<<<<.....>>>>>> (((((.......))))) Structure of the Ribosome Recycling Factor bound to the Thermus thermophilus 70S ribosome with mRNA, ASL-Phe and tRNA-fMet; P-SITE RNA ASL-PHE 4v5a AW 77 3.5 RF00005 URS000041AF00_562 17660830 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<.............>>>>>>>>..... .((((((..((((......[..))))...((.........))...........(..]....)....))))))..... Structure of the Ribosome Recycling Factor bound to the Thermus thermophilus 70S ribosome with mRNA, ASL-Phe and tRNA-fMet; TRNA-FMET 4v5a AX 11 3.5 17660830 32630 gauguucuagu ........... ........... Structure of the Ribosome Recycling Factor bound to the Thermus thermophilus 70S ribosome with mRNA, ASL-Phe and tRNA-fMet; MRNA 4v5a BA 2767 3.5 RF02540,RF02541,RF00002 URS000080E107_300852 17660830 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucgggggcccucggccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcgccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccagucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagcccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....[[..[[<<<<<<[[<<......<<<<<<.[...((.>>>.....<<<<<<<..<<<))...].>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<..>>>>>>.>>....<<<<<.....<......>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...(((....<<<<<<<<.....>>>>>>>>.....<<<<<<<<...<<...<<<.<.<<<<.<<<....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>...>>>>..>>..>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>.]]...............<<....>>....]].........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<....>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<...<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<.....<<....>>......>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<..................>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..(((....>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...........>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.........<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<.<<<<<<<...........<<<<<...............>>>>>..>>>>>>>.>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<.(((..>>>>..)))>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<<..<<.......>>>..>>>>>>....>>>.>.......<.<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>..>....<<<<<<<....>>>.>>>>........)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.)))>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<.......>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> .(.......((.(((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((....))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...(((((((.......)))))))....{(((.((((...((....((((.((((...(...(((((......)))))[[(...).(((.....]])))...).....))))..))))...))..))))..))))....(((((((((.[.....)))))))))....}.(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....))))))).)).....(.((((((((((....)))))))))).[.(.(........).).((((((....(((((((((((.(..(((...(((.....)))...)))...((....))..((((.....))))..).)))))))))))..((.(....(((((.....((((((((((.(.((...((((((......))))))...)[).)...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))).......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((.(..............)..))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((..((.....(.....((..(((((((......................))))))).))..........]]].)....))..))))))...)))))))(((((...........)))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.((...{{....))))))(((...((((((.((.((.(((.((.....))))).).).....)).))))))..)))(...........))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).((((......))))..))))..((((....(((((((..((..(....(.......(((((....(.{..).....)))))(((((.((((.........)))).)))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(.(((.........))).)........((..........(((((.......)))))..)..)....))))...)).))))))).)..)))..))))))).)))))).....))....(((((.....]..)))))..((((((((.(((.........((((.((((((..(((((.(((.(((((.(((((((((.(.((((.(.........(((((...............)))))).)))).).)))))))))...(((((....)))))....))))).)))..)))))..(((......[)))(((.((..........])).)))(.((...((.((((.(.(((((.........)))))...).((.[.[[[))....)))).))...(.((..(((...{..)))..)).).(((....))).))]]].].....((((((..((..]]]]..)).)))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.....)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))...................(((((((((.......)))))....(((.((((.(((....(((((....)))))...)))..))))..)))...)))).....). Structure of the Ribosome Recycling Factor bound to the Thermus thermophilus 70S ribosome with mRNA, ASL-Phe and tRNA-fMet; 23S ribosomal RNA 4v5a BB 119 3.5 RF00001 URS00005F2F4B_300852 17660830 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<........<<<<<<<....>>>>>>>........>>>.>>>>>>>>>> ..((.((((((....(((((.((....(((((((...(.....)...))))..)))...)).))).))(((.......((.(.(((....))).).)).......))).)))))).)). Structure of the Ribosome Recycling Factor bound to the Thermus thermophilus 70S ribosome with mRNA, ASL-Phe and tRNA-fMet; 5S ribosomal RNA 4v5a CA 1504 3.5 RF00177,RF01959,RF01960 URS000080E226_300852 17660830 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<.........>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<...<<<<<<......>>>>>.>...>>>>>....<<<<.<<<<<....>>>>>.>>>>...<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<........<<<.......>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>....<<.....>>....>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<....<.......>..>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((..(...(((..((.((((..(...........)..)))).)))))......(((......((((((((..((...(((((((.(((((....((...(....)...)).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((...(((((((.......))))))).)))......)))..((((((((....))))...))))))).(((((............))))).((((....))))....).))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....((((....(....((.(......))).....).....))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.(((((((.((......((((((.....))))))....)).)))))..)))))))))..(((.(((((...((((((((....((((((....((........)).......))))))....).......(......).)))))))..)))))..))..))))...))))....((((.....((....(.............)....))..))))......{...((((((..(..(((..((...))..)))..)...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((....(((((((.((......((........))..........(((((((..(...((........((...((....).)..)).......................))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.((((.((..(.................)...)).))))..(...((.(....).))......)..)))).....).).)))...)).)))).)...)))))))..[))..))))))).(...(((((((.....((....(..((((....))))..)......)).....)))))))...........(((((((........))))))).......)....))).....(.(((((......]...))))).)......))...)))))))))).))..(.(..((.(.((((.(((..(((((((.(((((...(.((((....(((....))).)))).)..))))).)))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Structure of the Ribosome Recycling Factor bound to the Thermus thermophilus 70S ribosome with mRNA, ASL-Phe and tRNA-fMet; 16S ribosomal RNA 4v5a CV 17 3.5 RF00005 URS00005AA258_32630 17660830 0030533 0006412 32630 ggggauugaaaaucccc .<<<<<.....>>>>>. .((((.......)))). Structure of the Ribosome Recycling Factor bound to the Thermus thermophilus 70S ribosome with mRNA, ASL-Phe and tRNA-fMet; P-SITE RNA ASL-PHE 4v5a CW 77 3.5 RF00005 URS000041AF00_562 17660830 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucggnucaaauccggcccccgcaacca .<<<<<...<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>.>>>>>..... .(.((.(..((((.........))))..((((.......))))........(.(.......).)...))).)..... Structure of the Ribosome Recycling Factor bound to the Thermus thermophilus 70S ribosome with mRNA, ASL-Phe and tRNA-fMet; TRNA-FMET 4v5a CX 11 3.5 17660830 32630 gauguucuagu ........... ........... Structure of the Ribosome Recycling Factor bound to the Thermus thermophilus 70S ribosome with mRNA, ASL-Phe and tRNA-fMet; MRNA 4v5a DA 2767 3.5 RF02540,RF02541,RF00002 URS000080E107_300852 17660830 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucgggggcccucggccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcgccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccagucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagcccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....[[..[[<<<<<<[[<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<..>>>>>>.>>....<<<<<.....<......>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...(((....<<<<<<<<.....>>>>>>>>.....<<<<<<<<...<<...<<<.<.<<<<.<<<....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>...>>>>..>>..>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>.]]...............<<....>>....]].........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<....>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<...<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<.....<<....>>......>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<..................>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<.........>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..(((....>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...........>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.........<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<.<<<<<<<...........<<<<<...............>>>>>..>>>>>>>.>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<.(((..>>>>..)))>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<<..<<.......>>>..>>>>>>....>>>.>.......<.<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>..>....<<<<<<<....>>>.>>>>........)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.)))>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<.......>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> .(.......(..(((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((....))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...(((((((.......)))))))....{(((.((((...((....((((.((((...(...(((((......)))))[[(...).(((.....]])))...).....))))..))))...))..))))..))))....(((((((((.[.....)))))))))....}.(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))..).....(.((((((((((....)))))))))).[.(.(........).).((((((....(((((((((((.(..(((...(((.....)))...)))...((....))..(.((.....)).)..).)))))))))))..((.(....(((((.....((((((((((.(.((...((((((......))))))...)[).)...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))).......).))...(((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((.(..............)..))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((..((.....(.....((..(((((((......................))))))).))..........]]].)....))..))))))...)))))))(((((...........)))))....))))).(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.((...{{....))))))(((...((((((.((.((.(((.((.....))))).).).....)).))))))..)))(...........))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).((((......))))..))))..((((....(((((((..((..(....(........((((....(.{..).....)))).((.((.((((.........)))).)).))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(.(((.........))).)........((..........(((((.......)))))..)..)....))))...)).))))))).)..)))..))))))).)))))).....))....(((((.....]..)))))..((((((((.(((.........((((.((((((..(((((.(((.(((((.(((((((((.(.((((.(.........(((((...............)))))).)))).).)))))))))...(((((....)))))....))))).)))..)))))..(((......[)))(((.((..........])).)))(.((...((.((((.(.(((((.........)))))...).((.[.[[[))....)))).))...(.((..(((...{..)))..)).).(((....))).))]]].].....((((((..((..]]]]..)).)))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.....)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))...................(((((((((.......)))))....(((.((((.(((....(((((....)))))...)))..))))..)))...)))).....). Structure of the Ribosome Recycling Factor bound to the Thermus thermophilus 70S ribosome with mRNA, ASL-Phe and tRNA-fMet; 23S ribosomal RNA 4v5a DB 119 3.5 RF00001 URS00005F2F4B_300852 17660830 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<........<<<<<<<....>>>>>>>........>>>.>>>>>>>>>> ..((.((((((....(((((.((....(((((((...(.....)...))))..)))...)).))).))(((.......((.(.(((....))).).)).......))).)))))).)). Structure of the Ribosome Recycling Factor bound to the Thermus thermophilus 70S ribosome with mRNA, ASL-Phe and tRNA-fMet; 5S ribosomal RNA 4v5b AA 117 3.74 RF00001 URS0000049E57_562 18288106 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggc <<<<<<<<......<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>....>>>>>>>> .(((.((.(.....((.(((((....(((.((...............))...)))...)))))..))..........((.((((.....)))).))............).)).))). Structure of PDF binding helix in complex with the ribosome.; 5S RIBOSOMAL RNA 4v5b AB 2841 3.74 RF02540,RF02541 URS00004B0F34_562 18288106 0003735 0005840 562 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<<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>...[.....<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))....].]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<.......>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<<..<<<<.......>>>>..>>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<....<<.....>>..>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>....................<<<<<<.....>>>>>>..........>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<.....<<<<<<<......>>>>>>>....>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<..<<<<...<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>......>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<<...>>>>>>.....<<..<<<<.........>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. .(((((((......((.(((((((.....(((..(((((((((((((......((((((.[....[.))).....((((((...((.]....]..)).......))))))...)))....(((....)))....(((....))).....(((((((((.........))))))))).))...((((((.........[.........))))).)..........(....)....(.(((........].........))).)...((((...((......((((((((..((..((....(((((......)))))((......[[......)).]]....))....))..))))))))...)).....)....((((.((...[.......).)))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....))))))).)).....(.((((..(((..........)))..)))).[.(.(........).).(((.((....(((((((((((((..(.....((.....)).....)...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....(((..(((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))..))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((...((((((.((.....(.(...((..(((.........)))..))..)..).....)).))).)))...))))))).)...((((.(((((......))))).))))....((........))...((((.(((...((([[[...(.((((((.....(.....((..((.((...((.....{...(((.(((..(((.........)))..))).....(..(..........)).))).....))...)).)).))...........]]].)...))))))))))...)))))))((((((((......))))))))....))))))..(((((...(((......((.((((......)))).))...)))..)))))........)).)))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((....((.......(((....)))........))....(((((........)))))]]((.((((((((((...((((....((((..(((..((((((((((.....{{{....)))))(...((((....(((((((((((.((.....))))))))))..)))...[))))....)(..(((((....)))))...))))))...)))...))))(..).....))))...))....)))))))).)).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(............(((((....(.{..).....)))))((((((.....(((...(.((....])).)...)))...)))))).............((((((((.].((.........))...(((((((.....(........).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).)))))).....))).)))))))).)))))).....))....(((((.....]..)))))..(((..(((.(((.((......((((.((((((..(((((.(((.(((((.(((..(.((((..((.......(.((((......)))).)......))..)))).)..)))....(..((((((.....)))))).).....))))).)))..)))))..(((.......)))((((((...........))))))([.....(((((((...(.(((.........))).).....((][.[[[))....)))))))...((((..(((...{..)))..))))..((....))....]]].](....((((((..((..]]]]..)).))))))...).)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......((((.((((.(..((((.((((......)))).)..)))..((((.....))))......).)))..)...))).).....(.(((.(....).).)).)....))..))))))..)))[...(((((((...((((..((.((((.....(....)....)))).)).(((((....(((...((((.(((((.}}}..)))))...))))...)))..)))))...(((......((.....}.......))......))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....((.((....)).))...))...))))).))).....))..).)))))))).. Structure of PDF binding helix in complex with the ribosome.; 23S RIBOSOMAL RNA 4v5b BA 1530 3.74 RF00177,RF01959,RF01960 URS00000ABFE9_562 18288106 0003735 0005840 562 ugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggauca ....<<<<....((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<...<<<<<<<<<<....>>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<..<.......>..>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<..<<<<<<.<<<<<<<<<<....<.<<<<<<.....>>>>>>.>..>>>>>>>>..>>>>>>>>....<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..))))..<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<........<<........>>..........<<<<<<<........<<<<<..<<.<<<<....>>>>.>>...<<....>>..>>>>>.....<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>....>>>>>>>......>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<...<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>...>>.>>>>..>.>>...>......<<<<<<<<....>>>>>>>>....... ....(.((...[.[...)).).((((..((.(..((...((((....(...(((..(((..((.(...((((.((.(((..))).)).).))).)..)))))......(((.......((((((..((...(((((((.(.((.....(.((((....)))).)......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))).(((....(((..((((((((.......)))))))))))......)))..(((((.((....)).)...))))))).(((((............))))).((((....))))...)))..).).......(((...(.............))))..)).)...))..((((......((((....)))).....)))).....((((....(...((((((.............))))).)...).....)))).......((((((((...[...[.....[[.)))]].......]...])))))..).)).))))..........(...[...(.((((...(...((((.(..(((((((.((......((((((.....))))))....)).)))))..)).).))))..(((((((((....((((((.......(((((.....................)))))..............((....)).))))))...)))).))))..)..)...))))....((.(((...((....(((.........)))....))))).))......{...((((.(...(((((((.(.(.....).).)))))))....((..].)).....).)))))..).(((......((((....))))....)))....]..]((.((.(((((((.....((((.....(((((.........((........))..........((.((((..(...(....(.....((.((....)).)).....(......)...).....)).((.((....((.(((......((((((.(......)....(((......)))...)))))).....((((.(((((((...((...((.....)).))....))))))).....((((.......))))........)))).......).))....))..))))....)))).)).......)))))........(((.((.....(((..((...((......))...))....))).....)).))).......(.....(.((((........)))).).....)......)))).....(((((((.........)))))))...........)))))))))..))....(..((.(.((((.(((..(.((((((((((.....(((((...(.............)..)))))....)))))))))).)..))).))))..).))...)......((((..((....))..)))).}..... Structure of PDF binding helix in complex with the ribosome.; 16S RIBOSOMAL RNA 4v5b CA 117 3.74 RF00001 URS0000049E57_562 18288106 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggc <<<<<<<<......<<<<<<<<.....<<<<<<.............>>>>..>>....>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>....>>>>>>>> (((((((((.....((.(((((.......((((...(.....)...))))........)))))..)).(........((.((((.....)))).))........)...))))))))) Structure of PDF binding helix in complex with the ribosome.; 5S RIBOSOMAL RNA 4v5b CB 2841 3.74 RF02540,RF02541 URS00004B0F34_562 18288106 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaacaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauggaaguguggacgccagucugcauggcuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>...[.....<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>.>..>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))....].]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<......<<...<<<.<<<<.......>>>>.>>>..>>.......>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<....<<.....>>..>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>....................<<<<<<.....>>>>>>..........>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<......<<<<<<<....>>>>>>>.....>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<..<<<<...<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>......>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<<...>>>>>>.....<<..<<<<.........>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((.(((((((.....(((..(((((((((((((......((((((.[....[.)))....(.(((((...(..]....]...).......)))))..).)))....(((....)))(((((..(...).))))).(((((((((.........))))))))).))...((((((.........[.........))))).)..........(....)....(.(((........].........))).)...((((..(((......(((..((.(.(((.(((...(((((......)))))........(((.......)))...)))...))).).))..)))...)))....)....((((.((...[.......).)))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....))))))).)).....(.((((..(((..........)))..)))).[...(........)...(((.((....(((((((((((((..(.....((.....)).....)...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((.(((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).)))).)))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((...((((((.((.....(((....(....((.......))....)...)).).....)).))).)))...))))))).)...((((.(((((......))))).))))....((........))...((((.(((...((([[[...(.((((((.....(.....((..(.......((.....{...(((........(.........)...............(((......)))..))).....)).......).))...........]]].)...))))))))))...)))))))((((((((......))))))))....))))))..(((((...(((......((.((((......)))).))...)))..)))))........)).)))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((....((..((...(((....)))...))...))....(((((........)))))]]((.((((((((((...((((....((((..(((..((((((((((.....{{{....)))))(...((((....(((((((((((.((.....))))))))))..)))...[))))....)(..(((((....)))))...))))))...)))...))))(..).....))))...))....)))))))).)).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(............(((((....(.{..).....)))))((((((.....(((...(.((....])).)...)))...)))))).............((((((((.].((.........))...(((((((.....(........).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).)))))).....))).)))))))).)))))).....))....(((((.....]..)))))..(((..(((.(((.((......((((.((((((..((.((.(((.(((((.(((((((.(((.((.(.........((........))........).)).))).)))))))....(..((((((.....)))))).).....))))).)))..)).))..(((.......)))((((((...........))))))([.....(((((((...(.(((.........))).).....((][.[[[))....)))))))...((((..(((...{..)))..))))..((....))....]]].].....((((((..((..]]]]..)).)))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......((((.((((.(..((((.((((......)))).)..)))..((((.....))))......).)))..)...))).).....(.(((.(....).).)).)....))..))))))..)))[...(((((((...((((..((.((((.....(....)....)))).)).(((((...((((...((((.(((((.}}}..)))))...))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....((.((....)).))...))...))))).))).....))..).))))))))). Structure of PDF binding helix in complex with the ribosome.; 23S RIBOSOMAL RNA 4v5b DA 1530 3.74 RF00177,RF01959,RF01960 URS00000ABFE9_562 18288106 0003735 0005840 562 ugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggauca ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<...<<<<<<<<<<....>>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<..[.>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<........<<<....>>>.......>>>...<.<<<<<.......<<<<<...<.......>...>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>.......]..<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<....<.<<<<<<.....>>>>>>.>..>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<..<<<<...<<<<<<<<........<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<<..<<<.....>>>>>.....>>>>>>.....<<<<<.....>>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>......>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>...........>>>>.....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ......[[..(.(((..]]...((((.(((((..((....(((....(...(((..(((..((.(...((((.((.(((..))).)).).))).)..)))))......(((.......((((((..((...(((((((.(.((.....(.((((....)))).)......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))..).).......(((...(.(........)..))))..)).....))..(.........(.((....)).)........)...(.((..(...(...((.(.(..(........).).).).)...)....)..))....)..(.(((.......((((.....((....)).......)))).))).)..)))))))))..........((([[...(.((......(..((((..(.((((((((((......(((((.......)))))....))))))))..)))..))))..(..((((((...((((((.(....((((((.......................))))))....).......((....))..))))))..)))).))....)..).....))....(((((.........((((.........))))......)))))......{...(.((((........(.((((.....)))).).........((..]])).....)))).))))).(((.......(((....))).....)))...))).)(.(((.(((((((.((...(((...(((.((.(.(.......(........)...........(((.((...(...(((((((..(((...(....)...)))...(......)..))))).))).(..(((...((((.(.(....((((((.((....))....(((......)))...)))))).....((.(..((........(...((.....)).).........)).......((((.....))))..........))).....).)..))...)).))).).....)).)))...)..).)).))).....((((((......(.(..((...(((....)))...))....).)......))))))..............((((........))))..............)))......(((((((.........)))))))......))...))))))))))..)..(.(..(....((((.(.(..(.((.(.((.......(((....(.((..((....)).)).)...)))......)).).)).)..).).)))).....)...)..)..(((((((((....)))))))))}..... Structure of PDF binding helix in complex with the ribosome.; 16S RIBOSOMAL RNA 4v5c AA 1504 3.3 RF00177,RF01959,RF01960 URS000080E226_300852 19363482 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<...........>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<.<<..<<<<<<<....>>>>>>>....<<.....>>....>>.>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<....<.......>.>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<...<<<<....>>>>...>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((.((...........)).)))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((.((.(...(((.(((....))).)))...................))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...(..............).....))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((...(..((((....))))..).....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((..........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Structure of the Thermus thermophilus 70S ribosome in complex with mRNA, paromomycin, acylated A-site tRNA, deacylated P-site tRNA, and E-site tRNA.; 16S ribosomal RNA 4v5c AV 77 3.3 RF00005 URS000041AF00_83333 19363482 0030533 0006412 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((.]....)))))))))))..... Structure of the Thermus thermophilus 70S ribosome in complex with mRNA, paromomycin, acylated A-site tRNA, deacylated P-site tRNA, and E-site tRNA.; P-SITE TRNA FMET 4v5c AW 76 3.3 RF00005 URS00005AA258_83333 19363482 0030533 0006412 83333 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((.........)))).....(((((..]....)))))))))))).... Structure of the Thermus thermophilus 70S ribosome in complex with mRNA, paromomycin, acylated A-site tRNA, deacylated P-site tRNA, and E-site tRNA.; E-SITE TRNA PHE 4v5c AX 10 3.3 19363482 32630 aaaauguuca .......... .......... Structure of the Thermus thermophilus 70S ribosome in complex with mRNA, paromomycin, acylated A-site tRNA, deacylated P-site tRNA, and E-site tRNA.; MRNA 4v5c AY 77 3.3 RF00005 URS000080E05A_83333 19363482 0030533 83333 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcaccnn <<<<<<<...<<..........>>..<<<<<<.....>>>>>>......<<<<.......>>>>.>>>>>>>..... .(.........................((((.......))))........(((.......))).......)..... Structure of the Thermus thermophilus 70S ribosome in complex with mRNA, paromomycin, acylated A-site tRNA, deacylated P-site tRNA, and E-site tRNA.; A-SITE PHE-TRNA PHE 4v5c BA 2807 3.3 RF02540,RF02541,RF00002 URS000080DFF3_300852 19363482 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucgggggcccucggccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccagucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<..>>>>>>.>>....<<<<<.....<<....>>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>.....<<<<<<<<...<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>..>>>>..>>..>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<....>>>>>>>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<...<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<..................>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...........>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<.......>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> .(.......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((....))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...((((((((.....))))))))....{(((((((((...(...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)..)))))).))))....(((((((((.[.....)))))))))....}.(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((.((((....)))).))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))..)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((...((((((......)))).))...)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((((......................))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.((...{{....))))))(((...((((((((((..((...((.....))..))..).....)))))))))..)))(...........))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((((.......)))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((.(((.(.((((.(......[..(((((..(((.......(((((((....)))))))....)))..........].)))))).)))).).))).)))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))...(.........).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...)))).....). Structure of the Thermus thermophilus 70S ribosome in complex with mRNA, paromomycin, acylated A-site tRNA, deacylated P-site tRNA, and E-site tRNA.; 23S Ribosomal RNA 4v5c BB 119 3.3 RF00001 URS00005F2F4B_300852 19363482 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>> .((((((((((....((((((((....(((.(((...(.....)...)))...)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))) Structure of the Thermus thermophilus 70S ribosome in complex with mRNA, paromomycin, acylated A-site tRNA, deacylated P-site tRNA, and E-site tRNA.; 5S RIBOSOMAL RNA 4v5c CA 1504 3.3 RF00177,RF01959,RF01960 URS000080E226_300852 19363482 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<...........>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<.<<..<<<<<<<....>>>>>>>....<<.....>>....>>.>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<....<.......>.>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<...<<<<....>>>>...>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<<..>>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((.((...........)).)))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((.((.(...(((.(((....))).)))...................))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...(..............).....))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((...(..((((....))))..).....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((..........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Structure of the Thermus thermophilus 70S ribosome in complex with mRNA, paromomycin, acylated A-site tRNA, deacylated P-site tRNA, and E-site tRNA.; 16S ribosomal RNA 4v5c CV 77 3.3 RF00005 URS000041AF00_83333 19363482 0030533 0006412 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((.]....)))))))))))..... Structure of the Thermus thermophilus 70S ribosome in complex with mRNA, paromomycin, acylated A-site tRNA, deacylated P-site tRNA, and E-site tRNA.; P-SITE TRNA FMET 4v5c CW 76 3.3 RF00005 URS00005AA258_83333 19363482 0030533 0006412 83333 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((........)))).((((.........)))).....(((((.......)))))))))))).... Structure of the Thermus thermophilus 70S ribosome in complex with mRNA, paromomycin, acylated A-site tRNA, deacylated P-site tRNA, and E-site tRNA.; E-SITE TRNA PHE 4v5c CX 10 3.3 19363482 32630 aaaauguuca .......... .......... Structure of the Thermus thermophilus 70S ribosome in complex with mRNA, paromomycin, acylated A-site tRNA, deacylated P-site tRNA, and E-site tRNA.; MRNA 4v5c CY 77 3.3 RF00005 URS000080E05A_83333 19363482 0030533 83333 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcaccnn <<<<<<<...<<..........>>..<<<<<<.....>>>>>>......<<<<.......>>>>.>>>>>>>..... ....((....(............)...(((.........))).........((.......))....))........ Structure of the Thermus thermophilus 70S ribosome in complex with mRNA, paromomycin, acylated A-site tRNA, deacylated P-site tRNA, and E-site tRNA.; A-SITE PHE-TRNA PHE 4v5c DA 2807 3.3 RF02540,RF02541,RF00002 URS000080DFF3_300852 19363482 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucgggggcccucggccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccagucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<..>>>>>>.>>....<<<<<.....<<....>>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>.....<<<<<<<<...<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>..>>>>..>>..>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<....>>>>>>>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<...<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<..................>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...........>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<.......>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> .(.......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((....))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...((((((((.....))))))))....{(((((((((...(...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)..)))))).))))....(((((((((.[.....)))))))))....}.(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((.((((....)))).))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))..)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((...((((((......)))).))...)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((((......................))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.((...{{....))))))(((...((((((((((..((...((.....))..))..).....)))))))))..)))(...........))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((((.......)))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((.(((.(.((((.(......[..(((((..(((.......(((((((....)))))))....)))..........].)))))).)))).).))).)))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))...(.........).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...)))).....). Structure of the Thermus thermophilus 70S ribosome in complex with mRNA, paromomycin, acylated A-site tRNA, deacylated P-site tRNA, and E-site tRNA.; 23S Ribosomal RNA 4v5c DB 119 3.3 RF00001 URS00005F2F4B_300852 19363482 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>> .((((((((((....((((((((....(((.(((...(.....)...)))...)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))) Structure of the Thermus thermophilus 70S ribosome in complex with mRNA, paromomycin, acylated A-site tRNA, deacylated P-site tRNA, and E-site tRNA.; 5S RIBOSOMAL RNA 4v5d AA 1504 3.5 RF00177,RF01959,RF01960 URS000080E226_300852 19363482 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<...........>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<..<..<<<<<<<....>>>>>>>....<<.....>>....>..>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<....<<.....>>.>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<<..>>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((.(.............).)))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((.(((((((...))))))).))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((.(..((((((((((......((........))..........(((((((..(...(((((.....(.((((......)))).)....................)))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...(..............).....)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((......((((....))))........))).....)))))))...........(((((((........))))))).......)..).))).....(((((((..........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Structure of the Thermus thermophilus 70S ribosome in complex with mRNA, paromomycin, acylated A- and P-site tRNAs, and E-site tRNA.; 16S ribosomal RNA 4v5d AV 77 3.5 RF00005 URS000080E05A_83333 19363482 0030533 83333 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcaccnn <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>..... (((((((..((((.....[..)))).(((((.......))))).....(((((..]....)))))))))))).... Structure of the Thermus thermophilus 70S ribosome in complex with mRNA, paromomycin, acylated A- and P-site tRNAs, and E-site tRNA.; P AND A-SITE PHE-TRNA PHE 4v5d AW 76 3.5 RF00005 URS00005AA258_83333 19363482 0030533 0006412 83333 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((........)))).((((.........)))).....((.((.......)).))))))))).... Structure of the Thermus thermophilus 70S ribosome in complex with mRNA, paromomycin, acylated A- and P-site tRNAs, and E-site tRNA.; E-SITE TRNA PHE 4v5d AX 11 3.5 19363482 32630 aaaauucuuca ........... ........... Structure of the Thermus thermophilus 70S ribosome in complex with mRNA, paromomycin, acylated A- and P-site tRNAs, and E-site tRNA.; MRNA 4v5d AY 77 3.5 RF00005 URS000080E05A_83333 19363482 0030533 83333 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcaccnn <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>..... (..((((..((............))..((((.......))))......((.((.......)).))))))..).... Structure of the Thermus thermophilus 70S ribosome in complex with mRNA, paromomycin, acylated A- and P-site tRNAs, and E-site tRNA.; P AND A-SITE PHE-TRNA PHE 4v5d BA 2807 3.5 RF02540,RF02541,RF00002 URS000080DFF3_300852 19363482 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucgggggcccucggccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccagucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....[[..[[<<<<<<[[<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<..>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...(((....<<<<<<<<.....>>>>>>>>.....<<<<<<<<...<<...<<<<..<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>...>>>>..>>..>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>.]]...............<<....>>....]].........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<....>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<...<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<..................>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..((((...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...........>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.........<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<.(((..>>>>..)))>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))))>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<.........>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> .(.......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((....))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((.........))))))....(((((((((....(...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)...))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((((((((....)))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))..)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((...((((((......)))).))...)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((....................)))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.((...{{....))))))(((...((((((((((.(((((.((.....))))))).).....)))))))))..)))(...........))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((((.......)))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((((.((((.(......[..(((((..(((......((((((((....))))))))...)))..........].)))))).)))).)))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.((.((.........)).))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))...(.........).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...)))).....). Structure of the Thermus thermophilus 70S ribosome in complex with mRNA, paromomycin, acylated A- and P-site tRNAs, and E-site tRNA.; 23S RIBOSOMAL RNA 4v5d BB 119 3.5 RF00001 URS00005F2F4B_300852 19363482 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>> ...((((((((....(((((..(....(((((((...(.....)...))))..)))...)..))).))(((.......((((((((....)))))))).......))).)))))))).. Structure of the Thermus thermophilus 70S ribosome in complex with mRNA, paromomycin, acylated A- and P-site tRNAs, and E-site tRNA.; 5S RIBOSOMAL RNA 4v5d CA 1504 3.5 RF00177,RF01959,RF01960 URS000080E226_300852 19363482 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<...........>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<..<..<<<<<<<....>>>>>>>....<<.....>>....>..>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<....<<.....>>.>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((.(.............).)))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.((.((....)).)).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((.(((((((...))))))).))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((....((((((((((......((........))..........(((((((..(...(((((.....(.((((......)))).)....................)))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...(..............).....)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((......((((....))))........))).....)))))))......(....(((((((........)))))))....)..)....))).....(((((((..........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Structure of the Thermus thermophilus 70S ribosome in complex with mRNA, paromomycin, acylated A- and P-site tRNAs, and E-site tRNA.; 16S ribosomal RNA 4v5d CV 77 3.5 RF00005 URS000080E05A_83333 19363482 0030533 83333 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcaccnn <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>..... (((((((..((((.....[..)))).(((((.......))))).....(((((..]....)))))))))))).... Structure of the Thermus thermophilus 70S ribosome in complex with mRNA, paromomycin, acylated A- and P-site tRNAs, and E-site tRNA.; P AND A-SITE PHE-TRNA PHE 4v5d CW 76 3.5 RF00005 URS00005AA258_83333 19363482 0030533 0006412 83333 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((........)))).((((.........)))).....(((((.......)))))))))))).... Structure of the Thermus thermophilus 70S ribosome in complex with mRNA, paromomycin, acylated A- and P-site tRNAs, and E-site tRNA.; E-SITE TRNA PHE 4v5d CX 11 3.5 19363482 32630 aaaauucuuca ........... ........... Structure of the Thermus thermophilus 70S ribosome in complex with mRNA, paromomycin, acylated A- and P-site tRNAs, and E-site tRNA.; MRNA 4v5d CY 77 3.5 RF00005 URS000080E05A_83333 19363482 0030533 83333 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcaccnn <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>..... ((..(((..((............))..((((.......))))......(((((.......))))))))..)).... Structure of the Thermus thermophilus 70S ribosome in complex with mRNA, paromomycin, acylated A- and P-site tRNAs, and E-site tRNA.; P AND A-SITE PHE-TRNA PHE 4v5d DA 2807 3.5 RF02540,RF02541,RF00002 URS000080DFF3_300852 19363482 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucgggggcccucggccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccagucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....[[..[[<<<<<<[[<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<..>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...(((....<<<<<<<<.....>>>>>>>>.....<<<<<<<<...<<...<<<<..<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>...>>>>..>>..>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>.]]...............<<....>>....]].........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<....>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<...<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<..................>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..((((...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...........>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.........<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<.(((..>>>>..)))>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))))>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<.........>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> .(.......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((....))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((.........))))))....(((((((((....(...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)...))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((((((((....)))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))..)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((...((((((......)))).))...)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((....................)))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.((...{{....))))))(((...((((((((((.(((((.((.....))))))).).....)))))))))..)))(...........))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((((.......)))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((((.((((.(......[..(((((..(((......((((((((....))))))))...)))..........].)))))).)))).)))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.((.((.........)).))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))...(.........).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...)))).....). Structure of the Thermus thermophilus 70S ribosome in complex with mRNA, paromomycin, acylated A- and P-site tRNAs, and E-site tRNA.; 23S RIBOSOMAL RNA 4v5d DB 119 3.5 RF00001 URS00005F2F4B_300852 19363482 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>> ...((((((((....(((((..(....(((((((...(.....)...))))..)))...)..))).))(((.......((((((((....)))))))).......))).)))))))).. Structure of the Thermus thermophilus 70S ribosome in complex with mRNA, paromomycin, acylated A- and P-site tRNAs, and E-site tRNA.; 5S RIBOSOMAL RNA 4v5e AA 1504 3.45 RF00177,RF01959,RF01960 URS000080E226_300852 18988853 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<...........>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>....<<<<.<<<<<....>>>>>.>>>>...<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<.<<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>...<<<.....>>>....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(....(((..((.(((((((...........))))))).)))))......(((......((((((((..((...(((((((.(((((....(((((......))))).....)))))....((((..((((....))))..))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....)))).....)))).).....(.(((...(((........)).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((.......(((((((....)))))))......................)))).((.(((...((((((.(....((((((..(....).....(((......)))...)))))).....((((.((((..(...(..............).....)..))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((...(..((((....))))..).....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((..........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Insights into translational termination from the structure of RF2 bound to the ribosome; 16S ribosomal RNA 4v5e AV 76 3.45 RF00005 URS00005AA258_83333 18988853 0030533 0006412 83333 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((........)))).(((((.......))))).....(((((.......)))))))))))).... Insights into translational termination from the structure of RF2 bound to the ribosome; E-SITE TRNA PHE OR P-SITE TRNA PHE (UNMODIFIED BASES) 4v5e AW 76 3.45 RF00005 URS00005AA258_83333 18988853 0030533 0006412 83333 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.......<<.........>>..>>>>>>>.... ((.(.(...((((........))))..(((.........)).).....(...............).)..))).... Insights into translational termination from the structure of RF2 bound to the ribosome; E-SITE TRNA PHE OR P-SITE TRNA PHE (UNMODIFIED BASES) 4v5e BA 2886 3.45 RF02540,RF02541,RF00002 URS000080E031_300852 18988853 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucgggggcccucggccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgggccgcacgcggcccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgcggcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgagucgcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu .<.......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<..>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>.....<<<<<<<<<<.<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<<<<<<<....>>>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<.<.<<<<<<......>>>>.>>>..>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...........>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>......>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<.........>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>.....>. .........((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((....))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((((((((..).))))))))....((((((((((...(...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)..)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((((((((....))))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((.(.((((((......)))).)))..))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.........(((.(((..(((.........)))..))).....(...((......)).).))).....)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.((...{{....))))))(((...((((((((((.(((((.((.....))))))).).....)))))))))..)))(...........))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((((.((((.(.........(((((..(((.......(((((((....)))))))....)))............)))))).)))).)))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))...(.........).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....... Insights into translational termination from the structure of RF2 bound to the ribosome; 23S RIBOSOMAL RNA 4v5e BB 119 3.45 RF00001 URS00005F2F4B_300852 18988853 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))) Insights into translational termination from the structure of RF2 bound to the ribosome; 5S RIBOSOMAL RNA 4v5e CA 1504 3.45 RF00177,RF01959,RF01960 URS000080E226_300852 18988853 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<...........>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>....<<<<.<<<<<....>>>>>.>>>>...<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<.<<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>...<<<.....>>>....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(....(((..((.(((((((...........))))))).)))))......(((......((((((((..((...(((((((.(((((....(((((......))))).....)))))....((((..((((....))))..))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....)))).....)))).).....(.(((...(((........)).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((.......(((((((....)))))))......................)))).((.(((...((((((.(....((((((..(....).....(((......)))...)))))).....((((.((((..(...(..............).....)..))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((...(..((((....))))..).....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((..........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Insights into translational termination from the structure of RF2 bound to the ribosome; 16S ribosomal RNA 4v5e CV 76 3.45 RF00005 URS00005AA258_83333 18988853 0030533 0006412 83333 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).(((((.......))))).....(((((..]....)))))))))))).... Insights into translational termination from the structure of RF2 bound to the ribosome; E-SITE TRNA PHE OR P-SITE TRNA PHE (UNMODIFIED BASES) 4v5e CW 76 3.45 RF00005 URS00005AA258_83333 18988853 0030533 0006412 83333 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((........)))).((((.........))))........(.........)...))))))).... Insights into translational termination from the structure of RF2 bound to the ribosome; E-SITE TRNA PHE OR P-SITE TRNA PHE (UNMODIFIED BASES) 4v5e DA 2886 3.45 RF02540,RF02541,RF00002 URS000080E031_300852 18988853 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucgggggcccucggccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgggccgcacgcggcccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgcggcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgagucgcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu .<.......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<..>>>>>>.>>....<<<<<.....<<....>>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>.....<<<<<<<<<<.<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<<<<<<<....>>>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<.<.<<<<<<......>>>>.>>>..>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...........>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>......>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<.........>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>.....>. .........((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((....))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((((((((..).))))))))....((((.(((((...(...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)..)))))..)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((((((((....))))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((.(.((((((......)))).)))..))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{...(((.(((..(((.........)))..))).....(...((......)).).))).....)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.((...{{....))))))(((...((((((((((.(((((.((.....))))))).).....)))))))))..)))(...........))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((((.((((.(.........(((((..(((.......(((((((....)))))))....)))............)))))).)))).)))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))...(.........).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....... Insights into translational termination from the structure of RF2 bound to the ribosome; 23S RIBOSOMAL RNA 4v5e DB 119 3.45 RF00001 URS00005F2F4B_300852 18988853 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))) Insights into translational termination from the structure of RF2 bound to the ribosome; 5S RIBOSOMAL RNA 4v5f AA 1504 3.6 RF00177,RF01959,RF01960 URS000080E226_300852 19833919 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<.........>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>....<<<<.<<<<<....>>>>>.>>>>...<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<..<<<...<<<<<<<....>>>>>>>....<<.....>>.....>>>..>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<...<<<..<<<.....>>>>>>....>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((.((...........)).)))).)))))......(((......((((((((..((...(((((((.(((((....((((.(....).)))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..(((((((.((......((........))..........(((((((..(...(..........(...((....))...).........................)).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((.............)))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[))..))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((.(((((....))))).)))}.. The structure of the ribosome with elongation factor G trapped in the post-translocational state; 16S ribosomal RNA 4v5f AV 77 3.6 RF00005 URS000041AF00_83333 19833919 0030533 0006412 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... The structure of the ribosome with elongation factor G trapped in the post-translocational state; E-SITE TRNA FMET OR P-SITE TRNA FMET (UNMODIFIED BASES EXCEPT FOR THYMINE 54) 4v5f AW 77 3.6 RF00005 URS000041AF00_83333 19833919 0030533 0006412 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((....((......[..))...(((.(.......).))).....(.(((..]....))).)))))))..... The structure of the ribosome with elongation factor G trapped in the post-translocational state; E-SITE TRNA FMET OR P-SITE TRNA FMET (UNMODIFIED BASES EXCEPT FOR THYMINE 54) 4v5f AX 11 3.6 19833919 32630 uaaaaauguuc ........... ........... The structure of the ribosome with elongation factor G trapped in the post-translocational state; MRNA 4v5f BA 2901 3.6 RF02540,RF02541,RF00002 URS000080E0F3_300852 19833919 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgggccgcacgcggcccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<......>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<.....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>.>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....<<<<<<<....>>>>>>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...................<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> .........((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((......(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)))..)))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...........................)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((...((.(((......)))..))...))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....((........))...((((.(((...((([[[...(.((.(((.....(.....((..(((((((.((.....{....((.(((..(((.........)))..))).....(...((......)).).))......)).))))))).))..........]]].)....))).))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.((...{{....))))))(((...((((((((((.(.(((.((.....))))).).).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((.(.....).))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((...((((.(.........(((((..(((......((((((((....))))))))...)))............)))))).))))...)))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))...................(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....... The structure of the ribosome with elongation factor G trapped in the post-translocational state; 23S RIBOSOMAL RNA 4v5f BB 119 3.6 RF00001 URS00005AB4A7_300852 19833919 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>> .((((((((((....(((((..(....(((((((...(.....)...))))..)))...)..))).))(((.......((.(((((....))))).)).......))).)))))))))) The structure of the ribosome with elongation factor G trapped in the post-translocational state; 5S RIBOSOMAL RNA 4v5f CA 1504 3.6 RF00177,RF01959,RF01960 URS000080E226_300852 19833919 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<.........>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>....<<<<.<<<<<....>>>>>.>>>>...<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<..<<<...<<<<<<<....>>>>>>>....<<.....>>.....>>>..>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<...<<<..<<<.....>>>>>>....>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((.((...........)).)))).)))))......(((......((((((((..((...(((((((.(((((....((((.(....).)))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..(((((((.((......((........))..........(((((((..(...(..........(...((....))...).........................)).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((.............)))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[))..))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.. The structure of the ribosome with elongation factor G trapped in the post-translocational state; 16S ribosomal RNA 4v5f CV 77 3.6 RF00005 URS000041AF00_83333 19833919 0030533 0006412 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... The structure of the ribosome with elongation factor G trapped in the post-translocational state; E-SITE TRNA FMET OR P-SITE TRNA FMET (UNMODIFIED BASES EXCEPT FOR THYMINE 54) 4v5f CW 77 3.6 RF00005 URS000041AF00_83333 19833919 0030533 0006412 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((.(..((((......[..)))).(((((.......))))).......(((..]....)))..).))))..... The structure of the ribosome with elongation factor G trapped in the post-translocational state; E-SITE TRNA FMET OR P-SITE TRNA FMET (UNMODIFIED BASES EXCEPT FOR THYMINE 54) 4v5f CX 11 3.6 19833919 32630 uaaaaauguuc ........... ........... The structure of the ribosome with elongation factor G trapped in the post-translocational state; MRNA 4v5f DA 2901 3.6 RF02540,RF02541,RF00002 URS000080E0F3_300852 19833919 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgggccgcacgcggcccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<......>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<.....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>.>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....<<<<<<<....>>>>>>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...................<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> .........((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((......(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)))..)))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...........................)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((...((.(((......)))..))...))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((.(((.....(.....((..(((((((.((.....{....((.(((..(((.........)))..))).....(...((......)).).))......)).))))))).))..........]]].)....))).))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.((...{{....))))))(((...((((((((((.(.(((.((.....))))).).).....)))))))))..)))(....(((....)))......))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((.(.....).))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((...((((.(.........(((((..(((......((((((((....))))))))...)))............)))))).))))...)))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))...................(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....... The structure of the ribosome with elongation factor G trapped in the post-translocational state; 23S RIBOSOMAL RNA 4v5f DB 119 3.6 RF00001 URS00005AB4A7_300852 19833919 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>> .((((((((((....(((((..(....(((((((...(.....)...))))..)))...)..))).))(((.......((.(((((....))))).)).......))).)))))))))) The structure of the ribosome with elongation factor G trapped in the post-translocational state; 5S RIBOSOMAL RNA 4v5g AA 1504 3.6 RF00177,RF01959,RF01960 URS000080E226_300852 19833920 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<...<..<<<.<<<..<<<..<<..<<<<<<...........>>>>>>..>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>....<<<<.<<<<<....>>>>>.>>>>...<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>...>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<(......<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<...)>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<.<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>....<<.....>>....>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<....<<.....>>.>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>..>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....((.......(((..((.((.(.(.............).).)).)))))......(((......((((((((..(....(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))...)))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).(((.(...)))).......)).).....(.(((...(.((......))..))))).)).))))))..((((......(((......))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.(((....(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))....)))....((((((....(...((((.........))))...).))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].]((((..(((((((.((..(((((..(((((((.((......((........))..........(((((((......(.((.......((...(....)...))......................)).)..((.(((...((((((.(....(((((((((....)))...(((......)))...))))))......(((.(((((((..((..............).)...))))))).....(((........)))........)))......).).)))...)).)))))....)))))))...))..))))))).(...(.(((((.....(.(..((..(.((....)).)..))....).).....))))).)......(....(((((((........)))))))....)..)..))))).....(((((((..........)))))))......))...))))))).)).))..(.(..((.(.((((.(((...((((((((((.(...(..(.(....((......)).).)..)..).))))))))))...))).))))..).))...)..)..(((((.(((....))).)))))}.. The crystal structure of the 70S ribosome bound to EF-Tu and tRNA; 16S RIBOSOMAL RNA 4v5g AV 76 3.6 RF00005 URS00005AA258_83333 19833920 0030533 0006412 83333 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<...<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<.........>>>>.>>>>>>.... (((((....((((........)))).(((((.......)))))......((((.......))))...))))).... The crystal structure of the 70S ribosome bound to EF-Tu and tRNA; E-SITE TRNA PHE OR P-SITE TRNA PHE 4v5g AW 76 3.6 RF00005 URS00005AA258_83333 19833920 0030533 0006412 83333 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca .<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>..... ..(((((...(.(.....[..).)..((((.........)))).....((.((..]....)).)))))))...... The crystal structure of the 70S ribosome bound to EF-Tu and tRNA; E-SITE TRNA PHE OR P-SITE TRNA PHE 4v5g AX 13 3.6 19833920 32630 aauguucaccaaa ............. ............. The crystal structure of the 70S ribosome bound to EF-Tu and tRNA; MRNA 4v5g AY 77 3.6 RF00005 URS000080E18C_300852 19833920 0030533 0006412 300852 gcugauauagcucagnnggnagagcgcacccuuggugagggugagnucggcagnucgaaucugccuaucagcaccaT .<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<.........>>>>>>>>>>...... .(((..(..(((......[...)))..((((.......)))).......(..(..]....)..).)..)))..... The crystal structure of the 70S ribosome bound to EF-Tu and tRNA; A-SITE TRNA THR 4v5g BA 2901 3.6 RF02540,RF02541,RF00002 URS000080E0F3_300852 19833920 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgggccgcacgcggcccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....[[..[[<<<<<<[[<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<......>>>>>.>>....<<<<<.....<......>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...(((....<<<<<<<<.....>>>>>>>>......<<<<<<<<.....<<<...<<<<..<<<<.<<<....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>...>>>>..>>>.>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>.]]...............<<....>>....]].........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<...<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<<<<<<<....>>>>>>>>....>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<........>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<....<<<(((.....<<<<<<...........<<..<<<<<<..<........<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>....>..>>>>>>.>>..........)))......>>>>>>.>>>....>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..((((...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.........<<<<.[[<<<<..<<<<..<<<.<<<<<.<<<<<<<<<<<<<<<<...........<..<...<<<......<<<<<<<<<..>>>>>>>>>...>>>............>..>...>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>...>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<.(((..>>>>..)))>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))))>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<.......>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> .........((..((((((.....(((..(((((((.((........(((((..[[..[[..)).....((((((...(((]]..]].)))......))))))...)))....(((....)))((.(.(((....))).).)).((((........))))......((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))....((....(((((.((.....)).)))))....(.(((..((((....(((...(((((..((..(((...((((........))))[[(...).(((.....]])))...)))....))...)))))..)))))))...))).....((((((((..[......))))))))....).(((((].[[[[)))))..)).......))..))))).))...............((....))....))......(..((((....))))..(......)..)).....))))))..)).....(.((((.((((((....)))))).)))).{.(.(........).).((((((....(((((((((((((....(...(((.....)))...).....((....))...(((.....)))..........(.......).........)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...){)))...(((..((((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...((((((((....(((...((((((((.(.((..(........)...)))..))))))))..)).)....))))))))..)..))))))).))..(((((((.((......)).))))))).....(..........)...((((.((....(((.[[...(.(((.((.....(.....((..((((((..(....................(...........).....................................)..)))))).))..........]]..)....)).)))))))....))))))(.((((.(.....).)))).)....))))))(.(((((...(((......(((((..((....)).)))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((...((((((...((.....)).))))))....[[.(((..(...((....(((....)))....))...)......(((........)))..]](((((((((((((...((((....(((((.(((...((((.((((.((.........))))))(((...(.((((((((...(((.((.....)))).)..).....))))))).)..)))(....(((....)))......)))))....)))..)))))(..).....))))...))...))))))))))))))...)).....((......)).)))).(((((....)))))..))))..(((.....((((((((.((..(....(.......(((((....(.[..).....)))))((((((((((.........))))))))))(...).......(((((((((.}.((.........))...(((((((.....(((....))).......))))))).]((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).))))))))..))))).....)).[..(((((.....}].)))))..((((((((.(((..(......((((.(.((((..(((((.(((.(((((.((..(...(((.((((............(.(....((........((((((....)))))).....)).............)..)...)))).)))...)..))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...((.((((.(.(((((.........)))))...)...][.[[[......)))).))...((((..(((...{..)))..)))).((......)).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))...)))))......(((((.(.((((((...((.......))...))))))...)))).).)......(.((..(((((..((((((............)))..))).(((((.....))))).....)))))......))..).....(((((((....))).))))....)...)))))))))))[...(((((((...((((..(((((.(.....(....)....).))))).(((((...(((....(((((((((((....))))))...)))))....))).)))))...(((....((((.............))))....))).))))..]....)))))))...((.......)).....((..(((((.......)))))....((..((((..((....(((((....)))))...))...))))...)).....))....... The crystal structure of the 70S ribosome bound to EF-Tu and tRNA; 23S RIBOSOMAL RNA 4v5g BB 119 3.6 RF00001 URS00005AB4A7_300852 19833920 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<.....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<........<<<<<<<....>>>>>>>........>>>..>>>>>>>>> ..(((((((((.......((..(....(((((((...(.....)...))))..)))...)..))....((........((.(((((....))))).))........)).))))))))). The crystal structure of the 70S ribosome bound to EF-Tu and tRNA; 5S RIBOSOMAL RNA 4v5g CA 1504 3.6 RF00177,RF01959,RF01960 URS000080E226_300852 19833920 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<...<..<<<.<<<..<<<..<<..<<<<<<...........>>>>>>..>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>....<<<<.<<<<<....>>>>>.>>>>...<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>...>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<(......<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<...)>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<.<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>....<<.....>>....>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<....<<.....>>.>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>..>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....((.......(((..((.((.(.(.............).).)).)))))......(((......((((((((..(....(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))...)))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).(((.(...)))).......)).).....(.(((...(.((......))..))))).)).))))))..((((......(((......))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.(((....(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))....)))....((((((....(...((((.........))))...).))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].]((((..(((((((.((..(((((..(((((((.((......((........))..........(((((((......(.((.......((...(....)...))......................)).)..((.(((...((((((.(....(((((((((....)))...(((......)))...))))))......(((.(((((((..((..............).)...))))))).....(((........)))........)))......).).)))...)).)))))....)))))))...))..))))))).(...(.(((((.....(.(..((..(.((....)).)..))....).).....))))).)......(....(((((((........)))))))....)..)..))))).....(((((((..........)))))))......))...))))))).)).))..(.(..((.(.((((.(((...(((.(.((((((...(.((((....(........).)))).)..)))))).).)))...))).))))..).))...)..)..(((((((((....)))))))))}.. The crystal structure of the 70S ribosome bound to EF-Tu and tRNA; 16S RIBOSOMAL RNA 4v5g CV 76 3.6 RF00005 URS00005AA258_83333 19833920 0030533 0006412 83333 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<...<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<.........>>>>.>>>>>>.... (((((....((((........)))).(((((.......)))))......((((.......))))...))))).... The crystal structure of the 70S ribosome bound to EF-Tu and tRNA; E-SITE TRNA PHE OR P-SITE TRNA PHE 4v5g CW 76 3.6 RF00005 URS00005AA258_83333 19833920 0030533 0006412 83333 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... ..(((((...(.(.....[..).)..((((.........)))).....((.((..]....)).)))))))...... The crystal structure of the 70S ribosome bound to EF-Tu and tRNA; E-SITE TRNA PHE OR P-SITE TRNA PHE 4v5g CX 13 3.6 19833920 32630 aauguucaccaaa ............. ............. The crystal structure of the 70S ribosome bound to EF-Tu and tRNA; MRNA 4v5g CY 77 3.6 RF00005 URS000080E18C_300852 19833920 0030533 0006412 300852 gcugauauagcucagnnggnagagcgcacccuuggugagggugagnucggcagnucgaaucugccuaucagcaccaT .<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<.........>>>>>>>>>>...... .(((..(..(((......[...)))..((((.......)))).......(..(..]....)..).)..)))..... The crystal structure of the 70S ribosome bound to EF-Tu and tRNA; A-SITE TRNA THR 4v5g DA 2901 3.6 RF02540,RF02541,RF00002 URS000080E0F3_300852 19833920 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgggccgcacgcggcccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....[[..[[<<<<<<[[<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<......>>>>>.>>....<<<<<.....<......>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...(((....<<<<<<<<.....>>>>>>>>......<<<<<<<<.....<<<...<<<<..<<<<.<<<....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>...>>>>..>>>.>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>.]]...............<<....>>....]].........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<...<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<<<<<<<....>>>>>>>>....>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<........>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<....<<<(((.....<<<<<<...........<<..<<<<<<..<........<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>....>..>>>>>>.>>..........)))......>>>>>>.>>>....>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..((((...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.........<<<<.[[<<<<..<<<<..<<<.<<<<<.<<<<<<<<<<<<<<<<...........<..<...<<<......<<<<<<<<<..>>>>>>>>>...>>>............>..>...>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>...>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<.(((..>>>>..)))>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))))>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<.......>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> .........((..((((((.....(((..(((((((.((........(((((..[[..[[..)).....((((((...(((]]..]].)))......))))))...)))....(((....)))((.(.(((....))).).)).((((........))))......((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))....((....(((((.((.....)).)))))....(.(((..((((....(((...(((((..((..(((...((((........))))[[(...).(((.....]])))...)))....))...)))))..)))))))...))).....((((((((..[......))))))))....).(((((].[[[[)))))..)).......))..))))).))...............((....))....))......(..((((....))))..(......)..)).....))))))..)).....(.(((..((((((....))))))..))).{.(.(........).).((((((....(((((((((((((....(...(((.....)))...).....((....))...(((.....)))..........(.......).........)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...){)))...(((..((((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...((((((((....(((...((((((((.(.((..(........)...)))..))))))))..)).)....))))))))..)..))))))).))..(((((((.((......)).))))))).....(..........)...(((..((....(((.[[...(.(((.((.....(.....((..((((((..(....................(...........).....................................)..)))))).))..........]]..)....)).)))))))....)).)))(.((((.(.....).)))).)....))))))(.(((((...(((......(((((..((....)).)))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((...((((((...((.....)).))))))....[[.(((..(...((....(((....)))....))...)......(((........)))..]](((((((((((((...((((....(((((.(((...((((.((((.((.........))))))(((...(.((((((((...(((.((.....)))).)..).....))))))).)..)))(....(((....)))......)))))....)))..)))))(..).....))))...))...))))))))))))))...)).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.[..).....)))))((((((((((.........))))))))))(...).......(((((((((.}.((.........))...(((((((.....(((....))).......))))))).]((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).[..(((((.....}].)))))..((((((((.(((..(......((((.(.((((..(((((.(((.(((((.((..(...(((.(((.............(.(....((........((((((....)))))).....)).............)..)....))).)))...)..))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...((.((((.(.(((((.........)))))...)...][.[[[......)))).))...((((..(((...{..)))..)))).((......)).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))...)))))......(((((.(.((((((...((.......))...))))))...)))).).)......(.((..(((((..((((((............)))..))).(((((.....))))).....)))))......))..).....(((((((....))).))))....)...)))))))))))[...(((((((...((((..(((((.(.....(....)....).))))).(((((...(((....(((((((((((....))))))...)))))....))).)))))...(((....((((.............))))....))).))))..]....)))))))...((.......)).....((..(((((.......)))))....((..((((..((....(((((....)))))...))...))))...)).....))....... The crystal structure of the 70S ribosome bound to EF-Tu and tRNA; 23S RIBOSOMAL RNA 4v5g DB 119 3.6 RF00001 URS00005AB4A7_300852 19833920 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<.....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<........<<<<<<<....>>>>>>>........>>>..>>>>>>>>> ..(((((((((.......((.((....(((((((...(.....)...))))..)))...)).))....(.........((.(((((....))))).)).........).))))))))). The crystal structure of the 70S ribosome bound to EF-Tu and tRNA; 5S RIBOSOMAL RNA 4v5h AA 1530 5.8 RF00177,RF01959,RF01960 URS000080E24C_562 19933110 0003735 0005840 562 ugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggauca ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<<....>>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>...<.<<<<<.......<<<<<<<.<.......>>>.>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.<.....<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<.....>>>>>........>>>>.....>...>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((((((((..)))))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((.(.......))).)))).....)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))..........((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((..(((((((....)))))))...((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.....]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))...... E.Coli 70s Ribosome Stalled During Translation Of Tnac Leader Peptide.; 16S RIBOSOMAL RNA 4v5h AV 77 5.8 RF00005 URS000034D020_562 19933110 0030533 0006412 562 cggcacguagcgcagccugguagcgcaccgucauggggugucgggggucggaggnucaaauccucucgugccgacca <<<<<<<..<<<<.........>>>>.<<<.<<.....>>.>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((......[..)))).(((.(.......).))).....(((((..]....)))))))))))).... E.Coli 70s Ribosome Stalled During Translation Of Tnac Leader Peptide.; P-SITE TRNA 4v5h AX 11 5.8 19933110 32630 aaaacccagua ........... ........... E.Coli 70s Ribosome Stalled During Translation Of Tnac Leader Peptide.; MRNA 4v5h BA 115 5.8 RF00001 URS000080DF7E_562 19933110 0003735 0005840 562 gcugcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggc <<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.....<.<<<<<<<<...>>>>>>>>...>...>>...>>>>.>>.> (((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))).)).) E.Coli 70s Ribosome Stalled During Translation Of Tnac Leader Peptide.; 5S RIBOSOMAL RNA 4v5h BB 2903 5.8 RF02540,RF02541 URS000080E25C_562 19933110 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<<.....>>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>.>........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<....<....>.....>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<..<<....>>...>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<..<<<<.<..........<<<<...........<<<<<<<<....>>>>>>>>..................>>>>.>.>>>>..>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<<...>>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((...(((((((((.(...(((...(((.((((...(((((((.....))))).))...)))).)))..)).)...).)))))).)))...))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(((((((...(((......((((((((....))))))))...)))..))))).)).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((..((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((((((((((...((((....((((..(((..(((((((((((....{{{...))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((((.(......[....(((...........((..((((....))))..))................].)))..).)))).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((...))))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). E.Coli 70s Ribosome Stalled During Translation Of Tnac Leader Peptide.; 23S RIBOSOMAL RNA 4v5j AA 1504 3.1 RF00177,RF01959,RF01960 URS000080E226_300852 20421507 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<.........>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>....<<<<.<<<<<....>>>>>.>>>>...<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<....<<<<<<....>>>>>>.....<<.....>>.....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<....<<.....>>.>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.((...(((..((.((((.(((.........))).)))).)))))......(((......((((((((..((...(((((((.(((((....((((.(....).)))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))....))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((.(....).)).....))))....(((((...(....((((.....)))).....)....)))))......(((.([[[...(((((.....((.]]])).......)))))).)))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((.....)))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((.......(.((......)).)......................)))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.((((((...((..............).)....))))))..(..(((.(....).))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...((.(.((.....(((..((..((((....))))..))....))).....)).).))......(....(((((((........)))))))....)..)..))))).....(((((((..........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Structure of the 70S ribosome bound to Release factor 2 and a substrate analog provides insights into catalysis of peptide release; 16S Ribosomal RNA 4v5j AV 77 3.1 RF00005 URS000080E05A_83333 20421507 0030533 83333 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcaccnn <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>..... (((((((..((((.....[..)))).(((((.......))))).....(((((..]....)))))))))))).... Structure of the 70S ribosome bound to Release factor 2 and a substrate analog provides insights into catalysis of peptide release; E-SITE TRNA PHE OR P-SITE TRNA PHE (UNMODIFIED BASES) 4v5j AW 77 3.1 RF00005 URS000080E05A_83333 20421507 0030533 83333 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcaccnn <<<<<<...<<<<........>>>>.<<<<.........>>>>.....<...............>.>>>>>>..... ((((.......(..........)....(((.........)).).........(.......).......)))).... Structure of the 70S ribosome bound to Release factor 2 and a substrate analog provides insights into catalysis of peptide release; E-SITE TRNA PHE OR P-SITE TRNA PHE (UNMODIFIED BASES) 4v5j BA 2901 3.1 RF02540,RF02541,RF00002 URS000080E0F3_300852 20421507 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgggccgcacgcggcccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<....>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<.....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>.>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...........................>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<.<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>.>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><....<<<....>>>......>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<.......>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> .........((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((((((((..).))))))))....(.(((((((.......((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))...)))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...........................)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((.(.(((.((......)).).)))..))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((((((...........((.(((..(((.........)))..))).........(........)...)).......))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.((...{{....))))))(((...((((((((((.(((((.((.....))))))).).....)))))))))..)))(.....(......).......))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((((.((((...........(((((.............((..((....))..).)...................)))))..)))).)))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))...(.........).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....... Structure of the 70S ribosome bound to Release factor 2 and a substrate analog provides insights into catalysis of peptide release; 23S RIBOSOMAL RNA 4v5j BB 119 3.1 RF00001 URS00005F2F4B_300852 20421507 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>> .((((((((((....(((((..(....(((((((...(.....)...))))..)))...)..))).))(((.......((.(((((....))))).)).......))).)))))))))) Structure of the 70S ribosome bound to Release factor 2 and a substrate analog provides insights into catalysis of peptide release; 5S RIBOSOMAL RNA 4v5j CA 1504 3.1 RF00177,RF01959,RF01960 URS000080E226_300852 20421507 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<.........>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>....<<<<.<<<<<....>>>>>.>>>>...<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<....<<<<<<....>>>>>>.....<<.....>>.....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<....<<.....>>.>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<<..>>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((.(((.........))).)))).)))))......(((......((((((((..((...(((((((.(((((....((((.(....).)))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...((.((....)).).))))).)).))))))..((((......((.(....).)).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((.....)))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((.......(.((......)).)......................)))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.((((((...((..............).)....))))))..(..(((.(....).))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...((.(.((.....(((..((..((((....))))..))....))).....)).).))......(....(((((((........)))))))....)..)..))))).....(((((((..........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Structure of the 70S ribosome bound to Release factor 2 and a substrate analog provides insights into catalysis of peptide release; 16S Ribosomal RNA 4v5j CV 77 3.1 RF00005 URS000080E05A_83333 20421507 0030533 83333 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcaccnn <<<<<<<..<<<<........>>>><<<<<<<.....>>>>>>.>...<<<<<.......>>>>>>>>>>>>..... (((((((..((((.....[..)))).(((((.......))))).....((.((..]....)).))))))))).... Structure of the 70S ribosome bound to Release factor 2 and a substrate analog provides insights into catalysis of peptide release; E-SITE TRNA PHE OR P-SITE TRNA PHE (UNMODIFIED BASES) 4v5j CW 77 3.1 RF00005 URS000080E05A_83333 20421507 0030533 83333 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcaccnn <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<.<<<.......>>>.>>>>>>>>..... (((((....((((........)))).((((.........))))........................))))).... Structure of the 70S ribosome bound to Release factor 2 and a substrate analog provides insights into catalysis of peptide release; E-SITE TRNA PHE OR P-SITE TRNA PHE (UNMODIFIED BASES) 4v5j DA 2901 3.1 RF02540,RF02541,RF00002 URS000080E0F3_300852 20421507 0003735 0005840 300852 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<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<....>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<.....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>.>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...........................>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<.<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>.>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><....<<<....>>>......>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<.......>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> .........((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((((((((..).))))))))....(.(((((((.......((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))...)))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...........................)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((.(.(((.((......)).).)))..))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((((((......{....((.(((..(((.........)))..))).........(........)...)).......))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.((...{{....))))))(((...((((((((((.(((((.((.....))))))).).....)))))))))..)))(.....(......).......))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((((.((((...........(((((.............((..((....))..).)...................)))))..)))).)))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))...(.........).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....... Structure of the 70S ribosome bound to Release factor 2 and a substrate analog provides insights into catalysis of peptide release; 23S RIBOSOMAL RNA 4v5j DB 119 3.1 RF00001 URS00005F2F4B_300852 20421507 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>> .((((((((((....(((((..(....(((((((...(.....)...))))..)))...)..))).))(((.......((.(((((....))))).)).......))).)))))))))) Structure of the 70S ribosome bound to Release factor 2 and a substrate analog provides insights into catalysis of peptide release; 5S RIBOSOMAL RNA 4v5k AA 1508 3.2 RF00177,RF01959,RF01960 URS000080E226_300852 20852642,16959973 0003735 0005840 300852 guuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgangucguaacaagguagcuguaccggaaggugcggcuggauc ......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<.........>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>....<<<<.<<<<<....>>>>>.>>>>...<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<.<<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>..>>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<.......<<<<<....<<..<<<....>>>.>>....................>>>>>..<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<....<<.....>>..>.....>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<......<<..<<..<<<<....>>>>..>>....>>......>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... ......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((.(((.........))).)))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((.....)))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((....((((((((((......((........))..........(((((((........(((.......(............)......................)))....((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((....((..............).).....))))).....(.((......)).)........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....((.......((.(....).)).........)).....)))))))......(....(((((((........)))))))....)..)....))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Structure of cytotoxic domain of colicin E3 bound to the 70S ribosome; 16S ribosomal RNA 4v5k AV 77 3.2 RF00005 URS000041AF00_83333 20852642,16959973 0030533 0006412 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(((.(.......).)))))))))..... Structure of cytotoxic domain of colicin E3 bound to the 70S ribosome; E-SITE TRNA PHE OR P-SITE TRNA PHE 4v5k AW 77 3.2 RF00005 URS000041AF00_83333 20852642,16959973 0030533 0006412 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca ....<<<...<<<.........>>>..<<<<<.......>>>>>......<<<.........>>>..>>>....... ...........(...........)....((((.......)))).................................. Structure of cytotoxic domain of colicin E3 bound to the 70S ribosome; E-SITE TRNA PHE OR P-SITE TRNA PHE 4v5k AX 16 3.2 20852642,16959973 32630 guaaaaauguucaaaa ................ ................ Structure of cytotoxic domain of colicin E3 bound to the 70S ribosome; MRNA 4v5k BA 2807 3.2 RF02540,RF02541,RF00002 URS000080E03F_300852 20852642,16959973 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucgggggcccucggccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccagucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<..>>>>>>.>>....<<<<<.....<<....>>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>.....<<<<<<<<...<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>..>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<...<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<....>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...........>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<..<.<<<<...........<<<<<..<<.......<<<<..<<...>>..>.>>>....>>............>>>>>..>>>>..>.>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<.........>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> .........((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((....))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((((((((..).))))))))....((((((((....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))...)))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))..)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...((((((.((...(((...((((((((.(.((((.(......).)).)))..))))))))..)).)...)).))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......(....)...)))))))))).))..........]]].)....))))))))))...)))))))((((((.(.....).))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.((..{{{....))))))(((...(((((((((..((((..((.....)).)))).......)))))))))..)))(...........))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((.(((((.(....................(..(.................................)............)............)))))).)))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.((.(...........).))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}}))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))...(.........).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....... Structure of cytotoxic domain of colicin E3 bound to the 70S ribosome; 23S ribosomal RNA 4v5k BB 119 3.2 RF00001 URS00005F2F4B_300852 20852642,16959973 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>> ..(((((((((....(((((.((....(((.(((...(.....)...)))...)))...)).))).))(((.......((.(((((....))))).)).......))).))))))))). Structure of cytotoxic domain of colicin E3 bound to the 70S ribosome; 5S ribosomal RNA 4v5k CA 1508 3.2 RF00177,RF01959,RF01960 URS000080E226_300852 20852642,16959973 0003735 0005840 300852 guuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgangucguaacaagguagcuguaccggaaggugcggcuggauc ......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<...<..<<<.<<<..<<<..<<.<<<<<<<...........>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>....<<<<.<<<<<....>>>>>.>>>>...<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>...>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<.<<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>..>>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<.......<<<<<....<<..<<<....>>>.>>....................>>>>>..<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<....<<.....>>..>....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<......<<..<<..<<<<....>>>>..>>....>>......>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<......>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... ......((((..[.[[[..)))).((((.((.((..((((((((.....(((.(((..(((..((.((((.(((.........))).)))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((.(...).)).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).......(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)).))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((.....)))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((....(((((((((.......((........))..........(((((((........(((.......(............)......................)))....((.(((...((((.(.(....(((((((((....)))...(((......)))...)))))).....((((.(((((....((..............).).....))))).......(........)..........)))).....).)..))...)).)))))....)))))))....).)))))))).(...(((((((.....((..........(....)............)).....)))))))......(....((.((((........)))).))....)..)....))).....(.(((((..........))))).)......))...)))))))))).))....(..((...(((...((..((((.((((..((...(...((.....((....))..))...)..))..)))).))))..))...)))....))...).....(((((((((....)))))))))}.... Structure of cytotoxic domain of colicin E3 bound to the 70S ribosome; 16S ribosomal RNA 4v5k CV 77 3.2 RF00005 URS000041AF00_83333 20852642,16959973 0030533 0006412 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..))))...(((.......))).......(.(((..]....))).)))))))..... Structure of cytotoxic domain of colicin E3 bound to the 70S ribosome; E-SITE TRNA PHE OR P-SITE TRNA PHE 4v5k CW 77 3.2 RF00005 URS000041AF00_83333 20852642,16959973 0030533 0006412 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca ....<<<..<<<<.........>>>>...<<<.......>>>........<.<<.......>>.>.>>>........ ......(...(.(.........).).........................................).......... Structure of cytotoxic domain of colicin E3 bound to the 70S ribosome; E-SITE TRNA PHE OR P-SITE TRNA PHE 4v5k DA 2807 3.2 RF02540,RF02541,RF00002 URS000080E03F_300852 20852642,16959973 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucgggggcccucggccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccagucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<..>>>>>>.>>....<<<<<.....<<....>>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>.....<<<<<<<<...<<...<<<<..<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>...>>>>..>>..>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<...<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<....>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...........>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<..<.<<<<...........<<<<<..<<.......<<<<..<<...>>..>.>>>....>>............>>>>>..>>>>..>.>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<.........>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> .........((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((....))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((((((((..).))))))))....((((((((....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))...)))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))..)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...((((((.((...(((...((((((((.(.((((.(......).)).)))..))))))))..)).)...)).))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......(....)...)))))))))).))..........]]].)....))))))))))...)))))))((((((.(.....).))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.((..{{{....))))))(((...(((((((((..((((..((.....)).)))).......)))))))))..)))(...........))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((.(((((.(....................(..(.................................)............)............)))))).)))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.((.(...........).))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}}))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))...(.........).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....... Structure of cytotoxic domain of colicin E3 bound to the 70S ribosome; 23S ribosomal RNA 4v5k DB 119 3.2 RF00001 URS00005F2F4B_300852 20852642,16959973 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>> ..(((((((((....(((((.((....(((.(((...(.....)...)))...)))...)).))).))(((.......((.(((((....))))).)).......))).))))))))). Structure of cytotoxic domain of colicin E3 bound to the 70S ribosome; 5S ribosomal RNA 4v5l AA 1504 3.1 RF00177,RF01959,RF01960 URS000080E226_300852 21051640 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<..<<.<........>>>..>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>....<<<<.<<<<<....>>>>>.>>>>...<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<.<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<.....>>.>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>..>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((...(.............)...)).)))))......(((......((((((((..((...(((((((.(((((....((((........)))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((.....)))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(.((......(((((((....))))))).....................)).)).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..((..............).)...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....((((.((........)).))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. The structure of EF-Tu and aminoacyl-tRNA bound to the 70S ribosome with a GTP analog; 16S RRNA 4v5l AV 76 3.1 RF00005 URS00005AA258_83333 21051640 0030533 0006412 83333 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((........)))).(((((.......))))).....(((((.......)))))))))))).... The structure of EF-Tu and aminoacyl-tRNA bound to the 70S ribosome with a GTP analog; E-SITE TRNA PHE OR P-SITE TRNA PHE 4v5l AW 76 3.1 RF00005 URS00005AA258_83333 21051640 0030533 0006412 83333 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((....((((........)))).((((.........)))).....(((((.......)))))..))))).... The structure of EF-Tu and aminoacyl-tRNA bound to the 70S ribosome with a GTP analog; E-SITE TRNA PHE OR P-SITE TRNA PHE 4v5l AX 14 3.1 21051640 83333 aaauguucuggaaa .............. .............. The structure of EF-Tu and aminoacyl-tRNA bound to the 70S ribosome with a GTP analog; MRNA 4v5l AY 77 3.1 RF00005 URS000080E2EE_83333 21051640 0030533 0006412 83333 aggggcgnaguucaannggnagaacaccggunuccanaaccgggunuugggagnucgagucucuccgccccugccaW <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>..... (((((((..((((........))))((((((.......))))).)...(((((.......)))))))))))).... The structure of EF-Tu and aminoacyl-tRNA bound to the 70S ribosome with a GTP analog; A-SITE TRNA G24A TRP-TRNA TRP 4v5l BA 2901 3.1 RF02540,RF02541,RF00002 URS000080E1F7_300852 21051640 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgggccgcacgcggcccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgcggcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu .<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<......>>>>>.>>....<<<<<.....<<....>>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<..<<<<.<<<....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>...>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....<<<<<<<....>>>>>>>....>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<........>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<..<........<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>....>..>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>>....<<<<....>>>>......>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<...............<...<<<......<<<<<<<<....>>>>>>>>...>>>.............>......>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>...<<.......>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>. .........(((.((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((.(((((....))))).)).((((((....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((((((.......)))))))....(.(((((((((.....(....(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))...).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((.(....).))............)).....)))))).))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..((....(((.....)))....))...((....))..((((.....))))...........................)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((.(....(((((....)))))(((((((((.(...(((((((((...(((...((((((((.(.((...............)))..))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((..((....................................................................))..)))))).))..........]]].)....))))))))))...)))))))((((((.(.....).))))))....).))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.((...{{....))))))(((...((((((((((..((((.((.....))))))..).....)))))))))..)))(....(((....)))......))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((.........))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((....(.(((...............(....((......(.((((........)))).)...))..............)......))).)....))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[....((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))).....(.......)......(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....... The structure of EF-Tu and aminoacyl-tRNA bound to the 70S ribosome with a GTP analog; 23S RIBOSOMAL RNA 4v5l BB 119 3.1 RF00001 URS00005AB4A7_300852 21051640 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<.......<<<<<<....<<<<<<...............>>>..>>>...>>>>>>...<<<.....<.<<<<<<<<....>>>>>>>>...>...>>>..>>>>>>>>> .((((((((((.......((.((....(((((((...(.....)...))))..)))...)).))....(((.......((.(((((....))))).)).......))).)))))))))) The structure of EF-Tu and aminoacyl-tRNA bound to the 70S ribosome with a GTP analog; 5S RIBOSOMAL RNA 4v5m AA 1504 7.8 RF00177,RF01959,RF01960 URS000080E226_300852 21124459 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<.........>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<..<<<...<<<<<<<....>>>>>>>....<<.....>>.....>>>..>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<...<<<..<<<.....>>>>>>....>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((.((...........)).)))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..(((((((.((......((........))..........(((((((..(...(..........(...((....))...).........................)).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((.............)))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[))..))))))).(...(((((((.....(((...(..((((....))))..).....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. tRNA tranlocation on the 70S ribosome: the pre-translocational translocation intermediate TI(PRE); 16S RRNA 4v5m AV 77 7.8 RF00005 URS000041AF00_300852 21124459 0030533 0006412 300852 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... tRNA tranlocation on the 70S ribosome: the pre-translocational translocation intermediate TI(PRE); TRNA 4v5m AX 11 7.8 21124459 300852 uaaaaauguuc ........... ........... tRNA tranlocation on the 70S ribosome: the pre-translocational translocation intermediate TI(PRE); MRNA 4v5m BA 2901 7.8 RF02540,RF02541,RF00002 URS000080E0F3_300852 21124459 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgggccgcacgcggcccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.[...((.>>>.....<<<<<<<..<<<))...].>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<......>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<.....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>.>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<<<<<<<....>>>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.........<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.......<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...................<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> .........((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((......(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)))..)))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...........................)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((...((.(((......)))..))...)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....((........))...((((.(((...((([[[...(.((((((.....(.....((..(((((((.((.....{....((.(((..(((.........)))..))).....(...((......)).).))......)).))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.((...{{....))))))(((...((((((((((.(((((.((.....))))))).).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((.(.....).))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((...((((.(.........(((((..(((......((((((((....))))))))...)))............)))))).))))...)))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))...................(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....... tRNA tranlocation on the 70S ribosome: the pre-translocational translocation intermediate TI(PRE); 23S RIBOSOMAL RNA 4v5m BB 119 7.8 RF00001 URS00005AB4A7_300852 21124459 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>> .((((((((((....(((((..(....(((((((...(.....)...))))..)))...)..))).))(((.......((.(((.(....).))).)).......))).)))))))))) tRNA tranlocation on the 70S ribosome: the pre-translocational translocation intermediate TI(PRE); 5S RIBOSOMAL RNA 4v5n AA 1504 7.6 RF00177,RF01959,RF01960 URS000080E226_300852 21124459 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<.........>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<.<<<<....<.<<<<....>>>>.>.....<<.....>>.....>>>>.>>.<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<...<<<...<<.....>>.>>>....>>>>>>.....<<<<<....>>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((.((...........)).)))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..(((((((.((......((........))..........(((((((..(...(..........(...((....))...).........................)).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((.............)))...))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))...))..))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((..........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. tRNA translocation on the 70S ribosome: the post- translocational translocation intermediate TI(POST); 16S RRNA 4v5n AV 77 7.6 RF00005 URS000041AF00_300852 21124459 0030533 0006412 300852 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... tRNA translocation on the 70S ribosome: the post- translocational translocation intermediate TI(POST); TRNA 4v5n AX 11 7.6 21124459 300852 uaaaaauguuc ........... ........... tRNA translocation on the 70S ribosome: the post- translocational translocation intermediate TI(POST); MRNA 4v5n BA 2901 7.6 RF02540,RF02541,RF00002 URS000080E0F3_300852 21124459 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgggccgcacgcggcccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<......>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<.....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>.>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<<<<<<<....>>>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.........<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.......<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...................<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> .........((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((......(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)))..)))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...........................)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((...((.(((......)))..))...))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....((........))...((((.(((...((([[[...(.((.(((.....(.....((..(((((((.((.....{....((.(((..(((.........)))..))).....(...((......)).).))......)).))))))).))..........]]].)....))).))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.((...{{....))))))(((...((((((((((.(((((.((.....))))))).).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((.(.....).))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((...((((.([........(((((..(((......((((((((...]))))))))...)))............)))))).))))...)))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))...(.........).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....... tRNA translocation on the 70S ribosome: the post- translocational translocation intermediate TI(POST); 23S RIBOSOMAL RNA 4v5n BB 119 7.6 RF00001 URS00005AB4A7_300852 21124459 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>> .((((((((((....(((((..(....(((((((...(.....)...))))..)))...)..))).))(((.......((.(((((....))))).)).......))).)))))))))) tRNA translocation on the 70S ribosome: the post- translocational translocation intermediate TI(POST); 5S RIBOSOMAL RNA 4v5p AA 1510 3.1 RF00177,RF01959,RF01960 URS000080E226_300852 21378964 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucaccu ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<.<........>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<.....>>.....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<...<<<.....>>>>......>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((.((.............)).))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((.[[[...(((((.....((.]]])).......))))).))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((.......((((((....))))))......................))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((.(...(..............).....).))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....((((((..........))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........ The crystal structure of EF-Tu and A9C-tRNA-Trp bound to a near- cognate codon on the 70S ribosome; 16S RRNA 4v5p AV 76 3.1 RF00005 URS00005AA258_83333 21378964 0030533 0006412 83333 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).(((((.......))))).....(((((..]....)))))))))))).... The crystal structure of EF-Tu and A9C-tRNA-Trp bound to a near- cognate codon on the 70S ribosome; E-SITE TRNA PHE OR P-SITE TRNA PHE 4v5p AW 76 3.1 RF00005 URS00005AA258_83333 21378964 0030533 0006412 83333 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca ..<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>...... ....((...((((........)))).((((.........)))).....((.(.........).)).))........ The crystal structure of EF-Tu and A9C-tRNA-Trp bound to a near- cognate codon on the 70S ribosome; E-SITE TRNA PHE OR P-SITE TRNA PHE 4v5p AX 17 3.1 21378964 562 uaaaaauguucugaaaa ................. ................. The crystal structure of EF-Tu and A9C-tRNA-Trp bound to a near- cognate codon on the 70S ribosome; MRNA 4v5p AY 77 3.1 RF00005 URS000080DD64_83333 21378964 0030533 0006412 83333 aggggcgncguucaannggnagagcaccggunuccanaaccgggunuugggagnucgagucucuccgccccugccaW <<<<<<<..<<<<........>>>><<<<<<.......>>>>>.>...<<<<<.......>>>>>>>>>>>>..... ((.((((...(((........))).((((((.......))))).)...(((((.......))))))))).)).... The crystal structure of EF-Tu and A9C-tRNA-Trp bound to a near- cognate codon on the 70S ribosome; A-SITE TRNA A9C TRP-TRNA TRP 4v5p BA 2901 3.1 RF02540,RF02541,RF00002 URS000080E1F7_300852 21378964 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgggccgcacgcggcccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgcggcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu 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.........((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((.(......)))))))....(.(((((((((......(...(((((.((((...(...(((((......)))))[[(...).(((.....]])))...).....))))..)))))..)..)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(.(...(((.....)))...).)...((....))..((((.....))))...........................)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((.(.((((..........)).)))..)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((((........{....((.......(............)..............(.........)..)).........))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((...(..{{....).))))(((...((((((((((..((((.((.....))))))..).....)))))))))..)))(....(((....)))......))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((.......((....[.....{..(..(...(((......((((((((...]))))))))...)))..........}.)..).....)).......)))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))...................(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....... The crystal structure of EF-Tu and A9C-tRNA-Trp bound to a near- cognate codon on the 70S ribosome; 23S RIBOSOMAL RNA 4v5p BB 119 3.1 RF00001 URS00005AB4A7_300852 21378964 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>> .((((((((((....(((((.((....(((((((...(.....)...))))..)))...)).))).))(((.......((.(((((....))))).)).......))).)))))))))) The crystal structure of EF-Tu and A9C-tRNA-Trp bound to a near- cognate codon on the 70S ribosome; 5S RIBOSOMAL RNA 4v5p CA 1510 3.1 RF00177,RF01959,RF01960 URS000080E226_300852 21378964 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucaccu ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<.<........>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<.....>>.....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<...<<<.....>>>>......>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((.((.............)).))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((.[[[...(((((.....((.]]])).......))))).))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((.......((((((....))))))......................))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((.(...(..............).....).))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....((((((..........))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........ The crystal structure of EF-Tu and A9C-tRNA-Trp bound to a near- cognate codon on the 70S ribosome; 16S RRNA 4v5p CV 76 3.1 RF00005 URS00005AA258_83333 21378964 0030533 0006412 83333 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).(((((.......))))).....(((((..]....)))))))))))).... The crystal structure of EF-Tu and A9C-tRNA-Trp bound to a near- cognate codon on the 70S ribosome; E-SITE TRNA PHE OR P-SITE TRNA PHE 4v5p CW 76 3.1 RF00005 URS00005AA258_83333 21378964 0030533 0006412 83333 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca ..<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>...... ....((...((((........)))).((((.........)))).....((.(.........).)).))........ The crystal structure of EF-Tu and A9C-tRNA-Trp bound to a near- cognate codon on the 70S ribosome; E-SITE TRNA PHE OR P-SITE TRNA PHE 4v5p CX 17 3.1 21378964 562 uaaaaauguucugaaaa ................. ................. The crystal structure of EF-Tu and A9C-tRNA-Trp bound to a near- cognate codon on the 70S ribosome; MRNA 4v5p CY 77 3.1 RF00005 URS000080DD64_83333 21378964 0030533 0006412 83333 aggggcgncguucaannggnagagcaccggunuccanaaccgggunuugggagnucgagucucuccgccccugccaW <<<<<<<..<<<<........>>>><<<<<<.......>>>>>.>...<<<<<.......>>>>>>>>>>>>..... ((.((((...(((........))).((((((.......))))).)...(((((.......))))))))).)).... The crystal structure of EF-Tu and A9C-tRNA-Trp bound to a near- cognate codon on the 70S ribosome; A-SITE TRNA A9C TRP-TRNA TRP 4v5p DA 2901 3.1 RF02540,RF02541,RF00002 URS000080E1F7_300852 21378964 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgggccgcacgcggcccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgcggcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu .<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<....>>>>>>.>>....<<<<<.....<......>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<.......>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>......<.<<<......>>>>......>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<........>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<.<........<<<<<.<.....<<.........>>.....>.........<<......>>...>>>>>....>.>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<.<<<..<<<............<..<...<<<......<<<<<<<<<..>>>>>>>>>...>>>............>..>...>.>>..>>>.>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<.......>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>. .........((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((.(......)))))))....(.(((((((((......(...(((((.((((...(...(((((......)))))[[(...).(((.....]])))...).....))))..)))))..)..)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(.(...(((.....)))...).)...((....))..((((.....))))...........................)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((.(.((((..........)).)))..)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((((........{....((.......(............)..............(.........)..)).........))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((...(..{{....).))))(((...((((((((((..((((.((.....))))))..).....)))))))))..)))(....(((....)))......))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((.......((....[.....{..(..(...(((......((((((((...]))))))))...)))..........}.)..).....)).......)))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))...................(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....... The crystal structure of EF-Tu and A9C-tRNA-Trp bound to a near- cognate codon on the 70S ribosome; 23S RIBOSOMAL RNA 4v5p DB 119 3.1 RF00001 URS00005AB4A7_300852 21378964 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>> .((((((((((....(((((.((....(((((((...(.....)...))))..)))...)).))).))(((.......((.(((((....))))).)).......))).)))))))))) The crystal structure of EF-Tu and A9C-tRNA-Trp bound to a near- cognate codon on the 70S ribosome; 5S RIBOSOMAL RNA 4v5q AA 1504 3.1 RF00177,RF01959,RF01960 URS000080E226_300852 21378964 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<...........>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<.....>>.>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<....<<.....>>.>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((..(.............)..))).)))))......(((......((((((((..((...(((((((.(((((....((((.(....).)))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((........(((((....))))).......................))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..((..............).)...))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....((((((..........))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. The crystal structure of EF-Tu and G24A-tRNA-Trp bound to a near- cognate codon on the 70S ribosome; 16S RRNA 4v5q AV 76 3.1 RF00005 URS00005AA258_83333 21378964 0030533 0006412 83333 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).(((((.......))))).....(((((..]....)))))))))))).... The crystal structure of EF-Tu and G24A-tRNA-Trp bound to a near- cognate codon on the 70S ribosome; E-SITE TRNA PHE OR P-SITE TRNA PHE 4v5q AW 76 3.1 RF00005 URS00005AA258_83333 21378964 0030533 0006412 83333 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca ...<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>....... ....(....((((.....[..)))).((((.........)))).......(((..]....)))....)........ The crystal structure of EF-Tu and G24A-tRNA-Trp bound to a near- cognate codon on the 70S ribosome; E-SITE TRNA PHE OR P-SITE TRNA PHE 4v5q AX 17 3.1 21378964 562 uaaaaauguucugaaaa ................. ................. The crystal structure of EF-Tu and G24A-tRNA-Trp bound to a near- cognate codon on the 70S ribosome; MRNA 4v5q AY 77 3.1 RF00005 URS000080E2EE_83333 21378964 0030533 0006412 83333 aggggcgnaguucaannggnagaacaccggunuccanaaccgggunuugggagnucgagucucuccgccccugccaW <<<<<<<..<<<..........>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>..... ((.((((..((((........))))((((((.......))))).)...(((((.......))))))))).)).... The crystal structure of EF-Tu and G24A-tRNA-Trp bound to a near- cognate codon on the 70S ribosome; A-SITE TRNA G24A TRP-TRNA TRP 4v5q BA 2901 3.1 RF02540,RF02541,RF00002 URS000080E1F7_300852 21378964 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgggccgcacgcggcccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgcggcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu 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.........((((((((((.....(((..((((((((((((......(((((..[[..[[..)).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((.(......)))))))....(.(((((((((.....((...(((((.((((...(...(((((......)))))[[(...).(((.....]])))...).....))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((((((((......)))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...........................)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((.(.(.((.(......).))..))..))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((.........{.....(...(...................)...........(.........)..)...........)))))).))..........]]].)....))))))))))...)))))))((((((.........))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((.(.(....(((...(((....)))...)))....)...(((((........)))))]](((((((((((.(...((((....(((((.(((..(((((.((((.((...{{....))))))(((...((((((((.(..(((..((.....)).)))..)......))))))))..)))(....(((....)))......))))))...)))..)))))(..).....))))...)....)))))))))))).)).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((.......((....[........(..(...(((......((((((((...]))))))))...)))............)..).....)).......)))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))...................(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....... The crystal structure of EF-Tu and G24A-tRNA-Trp bound to a near- cognate codon on the 70S ribosome; 23S RIBOSOMAL RNA 4v5q BB 119 3.1 RF00001 URS00005AB4A7_300852 21378964 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>> .((((((((((....(((((.((....(((((((...(.....)...))))..)))...)).))).))(((.......((.(((((....))))).)).......))).)))))))))) The crystal structure of EF-Tu and G24A-tRNA-Trp bound to a near- cognate codon on the 70S ribosome; 5S RIBOSOMAL RNA 4v5q CA 1504 3.1 RF00177,RF01959,RF01960 URS000080E226_300852 21378964 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<.<........>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<.....>>.>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<....<<.....>>.>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(.(..(.............)..).).)))))......(((......((((((((..((...(((((((.(((((....((((........)))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((........(((((....))))).......................))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...(..............).....))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....((((((..........))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((.....(.((((....(((....))).)))).)....)))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. The crystal structure of EF-Tu and G24A-tRNA-Trp bound to a near- cognate codon on the 70S ribosome; 16S RRNA 4v5q CV 76 3.1 RF00005 URS00005AA258_83333 21378964 0030533 0006412 83333 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((........)))).(((((.......))))).....(((((.......)))))))))))).... The crystal structure of EF-Tu and G24A-tRNA-Trp bound to a near- cognate codon on the 70S ribosome; E-SITE TRNA PHE OR P-SITE TRNA PHE 4v5q CW 76 3.1 RF00005 URS00005AA258_83333 21378964 0030533 0006412 83333 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca ...<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>....... (.(((((..(((......[...))).((((.........)))).....(.((...].....).))))).))).... The crystal structure of EF-Tu and G24A-tRNA-Trp bound to a near- cognate codon on the 70S ribosome; E-SITE TRNA PHE OR P-SITE TRNA PHE 4v5q CX 17 3.1 21378964 562 uaaaaauguucugaaaa ................. ................. The crystal structure of EF-Tu and G24A-tRNA-Trp bound to a near- cognate codon on the 70S ribosome; MRNA 4v5q CY 77 3.1 RF00005 URS000080E2EE_83333 21378964 0030533 0006412 83333 aggggcgnaguucaannggnagaacaccggunuccanaaccgggunuugggagnucgagucucuccgccccugccaW <<<<<<<..<<<..........>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>..... ((.((((..((((........))))((((((.......))))).)...(((((.......))))))))).)).... The crystal structure of EF-Tu and G24A-tRNA-Trp bound to a near- cognate codon on the 70S ribosome; A-SITE TRNA G24A TRP-TRNA TRP 4v5q DA 2901 3.1 RF02540,RF02541,RF00002 URS000080E1F7_300852 21378964 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgggccgcacgcggcccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgcggcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu .<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<....>>>>>>.>>....<<<<<.....<......>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<.......>>>>>>>......<<<<<<<<<....<<<...<<<<..<<<<.<<<....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>...>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....<<<..<....>....>>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<..<........<<<<<.<<....<...........>....>>.........<<......>>...>>>>>....>..>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<.<<<..<.<............<..<...<<<......<<<<<<<<<..>>>>>>>>>...>>>............>..>...>..>..>>>.>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<.......>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>. .........((((((((((.....(((..((((((((((((......(((((..[[..[[..)).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((((...........)))))....(.(((((((((.....((...(((((.((((...(...(((..........)))[[(...).(((.....]])))...).....))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((.(....).))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...........................)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((.(.(.((.(......).))..))..)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((...............(...(...................)...........(.........)..)...........)))))).))..........]]].)....))))))))))...)))))))((((((.........))))))....))))))(.(((((....((......(((((.(((....))))))))...))...)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((.(.(....(((...(((....)))...)))....)...(((((........)))))]](((((((((((.(...((((....(((((.(((..(((((.((((.((...{{....))))))(((...((((((((.(..(((..((.....)).)))..)......))))))))..)))(....(((....)))......))))))...)))..)))))(..).....))))...)....)))))))))))).)).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((.......((....[........(..(...(((......((((((((...]))))))))...)))............)..).....)).......)))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))...................(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....... The crystal structure of EF-Tu and G24A-tRNA-Trp bound to a near- cognate codon on the 70S ribosome; 23S RIBOSOMAL RNA 4v5q DB 119 3.1 RF00001 URS00005AB4A7_300852 21378964 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>> .((((((((((....(((((.((....(((((((...(.....)...))))..)))...)).))).))(((.......((.(((((....))))).)).......))).)))))))))) The crystal structure of EF-Tu and G24A-tRNA-Trp bound to a near- cognate codon on the 70S ribosome; 5S RIBOSOMAL RNA 4v5r AA 1510 3.1 RF00177,RF01959,RF01960 URS000080E226_300852 21378964 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucaccu ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<.<........>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<........>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((.(...............).))).)))))......(((......((((((((..((...(((((((.(((((....((((.(....).)))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((.......((((((....))))))......................))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...(..............).....))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.(..(....(((....))).)..).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........ The crystal structure of EF-Tu and Trp-tRNA-Trp bound to a cognate codon on the 70S ribosome.; 16S RRNA 4v5r AV 76 3.1 RF00005 URS00005AA258_83333 21378964 0030533 0006412 83333 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).(((((.......))))).....(((((..]....)))))))))))).... The crystal structure of EF-Tu and Trp-tRNA-Trp bound to a cognate codon on the 70S ribosome.; E-SITE TRNA PHE OR P-SITE TRNA PHE 4v5r AW 76 3.1 RF00005 URS00005AA258_83333 21378964 0030533 0006412 83333 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca ...<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>.>...... .(((((...((((........)))).((((.........)))).....((.((.......)).)).)))))..... The crystal structure of EF-Tu and Trp-tRNA-Trp bound to a cognate codon on the 70S ribosome.; E-SITE TRNA PHE OR P-SITE TRNA PHE 4v5r AX 17 3.1 21378964 83333 uaaaaauguucuggaaa ................. ................. The crystal structure of EF-Tu and Trp-tRNA-Trp bound to a cognate codon on the 70S ribosome.; MRNA 4v5r AY 77 3.1 RF00005 URS000080DE5D_83333 21378964 0030533 0006412 83333 aggggcgnaguucaannggnagagcaccggunuccanaaccgggunuugggagnucgagucucuccgccccugccaW <<<<<<<..<<<<........>>>><<<<<<.......>>>>>.>...<<<<<.......>>>>>>>>>>>>..... (((((((..((((........))))((((((.......))))).)...(((((.......)))))))))))).... The crystal structure of EF-Tu and Trp-tRNA-Trp bound to a cognate codon on the 70S ribosome.; A-SITE TRNA TRP-TRNA TRP 4v5r BA 2901 3.1 RF02540,RF02541,RF00002 URS000080E1F7_300852 21378964 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgggccgcacgcggcccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgcggcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu 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.........((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...(((((..(......).)))))....{.(((((((((.....((...(((((..(((.(.(...(((((......)))))[[(...).(((.....]])))...).)...)))...)))))..)).)))))).))))....(((((((((.[.....)))))))))....}.(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...........................)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((.(.(((((........))).)))..))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((((........{.....(.(.....((.........)).....).........(.........)..)..........))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((.(.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((.(...((((....(((((.(((..(((((.((((.(.(..{{....))))))(((...((((((((.(..((((.((.....))))))..)......))))))))..)))(....(((....)))......))))))...)))..)))))(..).....))))...)....)))))))))))).)).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((...(...((....[.....{..(..(...(((......((((((((...]))))))))...)))..........}.)..).....))....)..)))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((]..[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].......((((((..((..]]]]..)).)))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))...................(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....... The crystal structure of EF-Tu and Trp-tRNA-Trp bound to a cognate codon on the 70S ribosome.; 23S RIBOSOMAL RNA 4v5r BB 119 3.1 RF00001 URS00005AB4A7_300852 21378964 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>> .((((((((((....(.(((.((....(((((((...(.....)...))))..)))...)).)))..)(((.......((.(((((....))))).)).......))).)))))))))) The crystal structure of EF-Tu and Trp-tRNA-Trp bound to a cognate codon on the 70S ribosome.; 5S RIBOSOMAL RNA 4v5r CA 1510 3.1 RF00177,RF01959,RF01960 URS000080E226_300852 21378964 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucaccu ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<.<........>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<........>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((.(...............).))).)))))......(((......((((((((..((...(((((((.(((((....((((.(....).)))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((.......((((((....))))))......................))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...(..............).....))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........ The crystal structure of EF-Tu and Trp-tRNA-Trp bound to a cognate codon on the 70S ribosome.; 16S RRNA 4v5r CV 76 3.1 RF00005 URS00005AA258_83333 21378964 0030533 0006412 83333 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).(((((.......))))).....(((((..]....)))))))))))).... The crystal structure of EF-Tu and Trp-tRNA-Trp bound to a cognate codon on the 70S ribosome.; E-SITE TRNA PHE OR P-SITE TRNA PHE 4v5r CW 76 3.1 RF00005 URS00005AA258_83333 21378964 0030533 0006412 83333 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca ...<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>.>...... .(((((...((((........)))).((((.........)))).....((.((.......)).)).)))))..... The crystal structure of EF-Tu and Trp-tRNA-Trp bound to a cognate codon on the 70S ribosome.; E-SITE TRNA PHE OR P-SITE TRNA PHE 4v5r CX 17 3.1 21378964 83333 uaaaaauguucuggaaa ................. ................. The crystal structure of EF-Tu and Trp-tRNA-Trp bound to a cognate codon on the 70S ribosome.; MRNA 4v5r CY 77 3.1 RF00005 URS000080DE5D_83333 21378964 0030533 0006412 83333 aggggcgnaguucaannggnagagcaccggunuccanaaccgggunuugggagnucgagucucuccgccccugccaW <<<<<<<..<<<<........>>>><<<<<<.......>>>>>.>...<<<<<.......>>>>>>>>>>>>..... (((((((..((((........))))((((((.......))))).)...(((((.......)))))))))))).... The crystal structure of EF-Tu and Trp-tRNA-Trp bound to a cognate codon on the 70S ribosome.; A-SITE TRNA TRP-TRNA TRP 4v5r DA 2901 3.1 RF02540,RF02541,RF00002 URS000080E1F7_300852 21378964 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgggccgcacgcggcccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgcggcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu 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.........((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...(((((..(......).)))))....{.(((((((((.....((...(((((..(((.(.(...(((((......)))))[[(...).(((.....]])))...).)...)))...)))))..)).)))))).))))....(((((((((.[.....)))))))))....}.(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...........................)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((.(.(((((........))).)))..))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((((........{.....(.(.....((.........)).....).........(.........)..)..........))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((.(.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((.(...((((....(((((.(((..(((((.((((.(.(..{{....))))))(((...((((((((.(..((((.((.....))))))..)......))))))))..)))(....(((....)))......))))))...)))..)))))(..).....))))...)....)))))))))))).)).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((...(...((....[.....{..(..(...(((......((((((((...]))))))))...)))..........}.)..).....))....)..)))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((]..[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].......((((((..((..]]]]..)).)))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))...................(((((((((.......)))))....((((((((..((....((.((....)).))...))...))))).)))...))))....... The crystal structure of EF-Tu and Trp-tRNA-Trp bound to a cognate codon on the 70S ribosome.; 23S RIBOSOMAL RNA 4v5r DB 119 3.1 RF00001 URS00005AB4A7_300852 21378964 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>> .((((((((((....(.(((.((....(((((((...(.....)...))))..)))...)).)))..)(((.......((.(((((....))))).)).......))).)))))))))) The crystal structure of EF-Tu and Trp-tRNA-Trp bound to a cognate codon on the 70S ribosome.; 5S RIBOSOMAL RNA 4v5s AA 1504 3.1 RF00177,RF01959,RF01960 URS000080E226_300852 21378964 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<...........>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<.....>.>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((...................))).)))))......(((......((((((((..((...(((((((.(((((....((((.(.....))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((........((((((....)))))).......................)))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((.(..((..............).)...).))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((...((((((((((((...(.((((....(((....))).)))).)..))))))))))))...))).))))..).))...)..)..(((((((((....)))))))))}.. The crystal structure of EF-Tu and G24A-tRNA-Trp bound to a cognate codon on the 70S ribosome.; 16S RRNA 4v5s AV 76 3.1 RF00005 URS00005AA258_83333 21378964 0030533 0006412 83333 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).(((((.......))))).....(((((..]....)))))))))))).... The crystal structure of EF-Tu and G24A-tRNA-Trp bound to a cognate codon on the 70S ribosome.; E-SITE TRNA PHE OR P-SITE TRNA PHE 4v5s AW 76 3.1 RF00005 URS00005AA258_83333 21378964 0030533 0006412 83333 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca ...<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>....... ....(....((((........)))).((((.........)))).....((.((.......)).))..)........ The crystal structure of EF-Tu and G24A-tRNA-Trp bound to a cognate codon on the 70S ribosome.; E-SITE TRNA PHE OR P-SITE TRNA PHE 4v5s AX 17 3.1 21378964 83333 uaaaaauguucuggaaa ................. ................. The crystal structure of EF-Tu and G24A-tRNA-Trp bound to a cognate codon on the 70S ribosome.; MRNA 4v5s AY 77 3.1 RF00005 URS000080E2EE_83333 21378964 0030533 0006412 83333 aggggcgnaguucaannggnagaacaccggunuccanaaccgggunuugggagnucgagucucuccgccccugccaW <<<<<<<..<<<..........>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>..... (((((((..((((........))))((((((.......))))).)...(((((.......)))))))))))).... The crystal structure of EF-Tu and G24A-tRNA-Trp bound to a cognate codon on the 70S ribosome.; A-SITE TRNA G24A TRP-TRNA TRP 4v5s BA 2901 3.1 RF02540,RF02541,RF00002 URS000080E1F7_300852 21378964 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgggccgcacgcggcccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgcggcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu 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.........((((((((((.....(((..((((((((((((......(((((..[[..[[..)).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((((..(......).)))))....(.(((((((((......(...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)..)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[.[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(.(...(((.....)))...).)...((....))..((((.....))))...........................)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((.(.(((.((......)).).)))..))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((...(...........((...(...................)...........(.........)..)).......)...))))).))..........]]].)....))))))))))...)))))))(((((.(........))))))....))))))(.(((((....((......(((((.(((....))))))))...))...)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.((...{{....))))))(((...((((((((((..((((.((.....))))))..).....)))))))))..)))(....(((....)))......))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((......(.....[.....{..(..(...(((......((((((((...]))))))))...)))..........}.)..)......)......))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..].]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))...................(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....... The crystal structure of EF-Tu and G24A-tRNA-Trp bound to a cognate codon on the 70S ribosome.; 23S RIBOSOMAL RNA 4v5s BB 119 3.1 RF00001 URS00005AB4A7_300852 21378964 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>> .((((((((((....(((((.((....(((((((...(.....)...))))..)))...)).))).))(((.......((.(((((....))))).)).......))).)))))))))) The crystal structure of EF-Tu and G24A-tRNA-Trp bound to a cognate codon on the 70S ribosome.; 5S RIBOSOMAL RNA 4v5s CA 1504 3.1 RF00177,RF01959,RF01960 URS000080E226_300852 21378964 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<...........>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>....<<<<.<<<<<....>>>>>.>>>>...<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<.....>>.>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((...................))).)))))......(((......((((((((..((...(((((((.(((((....((((.(.....))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((........((((((....)))))).......................)))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((.(..((..............).)...).))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..(((.(...))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. The crystal structure of EF-Tu and G24A-tRNA-Trp bound to a cognate codon on the 70S ribosome.; 16S RRNA 4v5s CV 76 3.1 RF00005 URS00005AA258_83333 21378964 0030533 0006412 83333 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((........)))).(((((.......))))).....(((((.......)))))))))))).... The crystal structure of EF-Tu and G24A-tRNA-Trp bound to a cognate codon on the 70S ribosome.; E-SITE TRNA PHE OR P-SITE TRNA PHE 4v5s CW 76 3.1 RF00005 URS00005AA258_83333 21378964 0030533 0006412 83333 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<.<.<<..<<<..........>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>..>>>.... (.((.((..((............)).(.((.........)).).....((.............)))).).)).... The crystal structure of EF-Tu and G24A-tRNA-Trp bound to a cognate codon on the 70S ribosome.; E-SITE TRNA PHE OR P-SITE TRNA PHE 4v5s CX 17 3.1 21378964 83333 uaaaaauguucuggaaa ................. ................. The crystal structure of EF-Tu and G24A-tRNA-Trp bound to a cognate codon on the 70S ribosome.; MRNA 4v5s CY 77 3.1 RF00005 URS000080E2EE_83333 21378964 0030533 0006412 83333 aggggcgnaguucaannggnagaacaccggunuccanaaccgggunuugggagnucgagucucuccgccccugccaW <<<<<<<..<<<..........>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>..... (((((((...(((........))).((((((.......))))).)...(((((.......)))))))))))).... The crystal structure of EF-Tu and G24A-tRNA-Trp bound to a cognate codon on the 70S ribosome.; A-SITE TRNA G24A TRP-TRNA TRP 4v5s DA 2901 3.1 RF02540,RF02541,RF00002 URS000080E1F7_300852 21378964 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgggccgcacgcggcccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgcggcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu 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.........((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((((..(......).)))))....(.(((((((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[.[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(.(...(((.....)))...).)...((....))..((((.....))))...........................)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((.(.(((.((......)).).)))..)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((...(...........((...(...................)...........(.........)..)).......)...))))).))..........]]].)....))))))))))...)))))))(((((.((.....).))))))....))))))(.(((((....((......(((((.(((....))))))))...))...)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.((...{{....))))))(((...((((((((((...(((.((.....)))))...).....)))))))))..)))(....(((....)))......))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((......((....[........(..(...(((.......(((((((...])))))))....)))............)..).....))......))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..].]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))....(........).....(((((((((.......)))))....((((((((..((....(((.(....).)))...))...))))).)))...))))....... The crystal structure of EF-Tu and G24A-tRNA-Trp bound to a cognate codon on the 70S ribosome.; 23S RIBOSOMAL RNA 4v5s DB 119 3.1 RF00001 URS00005AB4A7_300852 21378964 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>> .((((((((((....(((((.((....(((((((...(.....)...))))..)))...)).))).))(((.......((.(((((....))))).)).......))).)))))))))) The crystal structure of EF-Tu and G24A-tRNA-Trp bound to a cognate codon on the 70S ribosome.; 5S RIBOSOMAL RNA 4v5y AA 1530 4.45 RF00177,RF01959,RF01960 URS00000ABFE9_562 17660832 0003735 0005840 562 ugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggauca ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<<....>>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>...<.<<<<<......<.<<<<<<.<.<...>.>>>.>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((((((((..)))))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(...(((((((.(.......))).)))).)...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))...((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.....]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Crystal structure of the bacterial ribosome from Escherichia coli in complex with paromomycin and ribosome recycling factor (RRF).; 16S rRNA 4v5y BA 117 4.45 RF00001 URS0000049E57_562 17660832 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggc <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>> (((((((((.....((((((((.....((((((...(.....)...))))..))....)))))).)).((.......((((((((...)))))))).......))...))))))))) Crystal structure of the bacterial ribosome from Escherichia coli in complex with paromomycin and ribosome recycling factor (RRF).; 5S rRNA 4v5y BB 2841 4.45 RF02540,RF02541 URS00004B0F34_562 17660832 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaacaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauggaaguguggacgccagucugcauggcuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<.......>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<.....<<<<<<<<....>>>>>>>>....>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>.(<<...<<<<<<<...<<<<<<.......>>>>>>.....<<)..(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<<...>>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((...(((((((((.(...(((...(((.((((.......)))).)))..)).)...).)))))).)))...))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.......(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((..((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((.....{{{....)))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((((.(...((((((((....))))))))..).)))).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..(....)..]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.((((((...))))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Crystal structure of the bacterial ribosome from Escherichia coli in complex with paromomycin and ribosome recycling factor (RRF).; 23S rRNA 4v5y CA 1530 4.45 RF00177,RF01959,RF01960 URS00000ABFE9_562 17660832 0003735 0005840 562 ugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggauca ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<<<..>>>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>...<.<<<<<......<.<<<<<<.<.<...>.>>>.>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<.<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>..>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((((((((..)))))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(...(((((((.(.......))).)))).)...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))...((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.....]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Crystal structure of the bacterial ribosome from Escherichia coli in complex with paromomycin and ribosome recycling factor (RRF).; 16S rRNA 4v5y DA 117 4.45 RF00001 URS0000049E57_562 17660832 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggc <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>> (((((((((.....((((((((.....((((((...(.....)...))))..))....)))))).)).((.......((((((((...)))))))).......))...))))))))) Crystal structure of the bacterial ribosome from Escherichia coli in complex with paromomycin and ribosome recycling factor (RRF).; 5S rRNA 4v5y DB 2841 4.45 RF02540,RF02541 URS00004B0F34_562 17660832 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaacaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauggaaguguggacgccagucugcauggcuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<.......>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<......<<<<<<<......>>>>>>>.....>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>.(<<...<<<<<<<...<<<<<<.......>>>>>>.....<<)..(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<<...>>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((...(((((((((.(...(((...(((.((((.......)))).)))..)).)...).)))))).)))...))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((..((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((.....{{{....)))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((((.(...(((((((......)))))))..).)))).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..(....)..]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((...))))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Crystal structure of the bacterial ribosome from Escherichia coli in complex with paromomycin and ribosome recycling factor (RRF).; 23S rRNA 4v61 AA 1478 9.4 RF00177,RF01959,RF01960 URS000080E242_3562 18042701 0003735 0005840 3562 uggagaguucgauccuggcucaggaugaacgcuggcggcaugcuuaacacaugcaagucggacgggaagugguguuuccaguggcggacgggugaguaacgcguaagaaccugcccuugggaggggaacaacagcuggaaacggcugcuaauaccccguaggcugagaagcaaaaggaggaauccgcccgaggaggggcucgcgucugauuagcuaguuggugagguaauagcuuaccaaggcgaugaucaguagcugguccgagaggaugaucagccacacugggacugagacacggcccagacuccuacgggaggcagcaguggggaauuuuccgcaaugggcgaaagccugacggagcaaugccgcguggaggcagaaggcccacgggucgugaacuucuuuucccggagaagaagcaaugacgguauccggggaauaagcaucggcuaacucugugccagcagccgcgguaagacagaggaugcaagcguuauccggaaugauugggcguaaagcgucuguagguggcuuuuuaaguccgccgucaaaucccagggcucaacccuggacaggcgguggaaacuaccaagcuggaguacgguaggggcagagggaauuuccgguggagcggugaaaugcguagagaucggaaagaacaccaacggcgaaagcacucugcugggccgacacugacacugagagacgaaagcuaggggagcgaaugggauuagauaccccaguaguccuagccguaaacgauggauacuaggcgcugugcguaucgacccgugcaguguuguagcuaacgcguuaaguaucccgccuggggaguacguucgcaagaaugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaaagcgaagaaccuuaccagggcuugacaugccgcgaauccucuugaaagagaggggugccuucgggaacgcggacacagguggugcauggcugucgucagcucgugccguaagguguuggguuaagucccgcaacgagcgcaacccucguguuuaguugccaacguugaguuuggaacccugaacagacugccggugauaagccggaggaaggugaggaugacgucaagucaucaugccccuuaugcccugggcgacacacgugcuacaauggccgggacaaagggucgcgaucccgcgagggugagcuaaccccaaaaacccguccucaguucggauugcaggcugcaacucgccugcaugaagccggaaucgcuaguaaucgccggucagcaauacggcggugaauucguucccgggccuuguacacaccgcccgucacacuaugggagcuggccaugcccgaagucguuaccuuaaccgcaaggagggggaugccgaaggcagggcuagugacuggagugaagucguaacaagguagccguacuggaaggugcggcuggauca ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<......>>>..>>>>>......<<.......<<<<.<<..<<<..<<<<<<<.<<<<.....<<<<<......>>>>>......>>>>....<<<....>>>....<<<....>>>.>>>>>>>.>>>.>>.>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<.......<<<....>>>......>>>>.....<<<<<..................>>>>>.......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<..<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>..>>>>...<<<.<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>.>..........<<....>>.>>>>>>>..>>>>..>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<....<<<<.<......>.>>>>.....>....<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<............>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<.<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>.>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<.<<<<....<.<<<<.<<<<..<<....>>.>>>>>>>>.>...>>>>.>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ....((((..[.[[[..)))).((((.(((((..((((((((.....(((.(((..(((..((.(............)..)))))......(((......(((..((..(((..(((.(((.(.((.....((((((....))))))......)).)....(((....)))....(((....))).))).))).))).))..)))(((....(((..(((((.((.......)).))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).........(((...(((((....)))).))))..)).))))))..(.(.......((((....))))......).).....(((((...(.........)....))))).......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[.....((((...(((.((((....(((((.((((......((((((.....))))))....)))).)))..))...))))...(((.(((....((((((((...((((((((...((........))......))))))))...).......((....)).)))))))...)))..)))...)))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(....((((.(......).)))).....)....((..]])).....)))))).))).(((......((((....))))....)))...]]].](((((.((((((...(..(((((..((((((((((......((........))........(.(((((((......(((((((...(((((......)))))....((....))..))))).))..((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.((((.((...((............))....)).)))).....((((.......))))........)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...((.(((......(((..((...(((....)))...))....)))......))).))......(....(((((((........)))))))....)..)..))))).....(((((((.....]....)))))))......).....))))))))).))....(..((.(.((((.(((..((((.((.((((....(.((((.((((..((....)).)))))))).)...)))).)).))))..))).))))..).))...).....((((((((......))))))))}..... Homology model for the Spinach chloroplast 30S subunit fitted to 9.4A cryo-EM map of the 70S chlororibosome.; 16S rRNA 4v61 BA 2732 9.4 RF02540,RF02541 URS000080E0E5_3562 18042701 0003735 0005840 3562 uucaaacgaggaaaggcuuacgguggauaccuaggcacccagagacgaggaagggcguauuaaucgacgaaaugcuucggggaguugaaaauaagcagagauccggagauucccgaauaggucaaccuuucgaacuucugcugaauccaugggcaggcaagagacaaccuggcgaacugaaacaucuuaguagccagaggaaaagaaagcaaaagcgauucccguaguagcggcgagcgaaaugggagcagccuagagcaauacaagcgucgugcugcuaggcgaaucaguggagugcggaacccuagauggugaaaguccaguagccgaaagcaucacuagcuuaugcucgaguagcauggggcacguggaaucccgugugaaucagcaaggaccaccuugcaaggcuaaauacuccugggugaccgauagcgaaguaguaccgugagggaagggugaaaagaacccccaucggggagugaaauagaacaugaaaccguaagcucucaagcagugggagggggaccagacccugaccgcgugccuguugaagaaugagccggcgacucauaggcaguggcuugguuaagggaacccaccggagccguagcgaaagcgagucuucauagggcaauugucacugcuuauggacccgaaccugggugaucuauccaugaccaggaugaagcuugggugaaacuaaguggagguccgaaccgacugauguugaagaaucagcggaugaguugugguuaggggugaaaugccacucgaacccagagcuagcugguucuccccgaaaugcguugaggcgcagcaguugacuggacaucuagggguaaagcacuguuucggugcgggccgcgguaccaaaucgaggcaaacucugaauacuagauagucaaggucggccagugagacgaugggggauaagcuucaucgucgagagggaaacagcccggaucaccagcuaaggccccuaaaugaccgcucagugauaaaggagguaggggugcagagacagccaggagguuugccuagaagcagccacccuugaaagagugcguaauagcucacugaucgagcgcucuugcgccgaagaugaacggggcuaagcggucugccgaagcugugggauguaaaaaaacaucgguaggggagcguuccguguuagggagaaacgcgugcgugagccgcguuggacgaagcggaagcgagaaugucggcuugaguaacgcaaacauuggugagaauccaaugccccgaaaaccuaaggguuccuccgcaagguucguccacggagggugagucagggccuaagaucaggccgaaaggcguagucgauggacaacaggugaauauuccuguacuaccccuuguuggucccgagggacggaggaggcuagguuagccgaaagaugguuaucgguucaaggacgcaaggugggguagagaaaaugccucgagccaauguucgaguaccaggcgcuacggcgcugaaguaaccgaugccauacucccaggaaaagcucgaaagaccuucaacaaaaggguaccuguacccgaaaccgacacagguagguagguagagaauaccuaggggcgcgagacaacucucucuaaggaacucggcaaaauagccccguaacuucgggagaaggggugcccccucacaaagggggucgaagugaccaggcccgggcgacuguuuaccaaaaacacaggucuccgcaaagucguaagaccauguaugggggcugacgccugcccagugccggaaggucaaggaaguuggugaccugaugacaggggagccggcgaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgacccgcacgaaaggcguaacgaucugggcacugucucggagagaggcucggugaaauagacaugucugugaagaugcggacuaccugcaccuggacagaaagacccuaugaagcuuuacuguucccugggauuggcuuugggcuuuuccugcgcagcuuagguggaaggcgaagaaggcccccuuccgggggggcccgagccaucagugagauaccacucuggaagagcuagaauucuaaccuugugucaggaccuacgggccaagggacauucucagguagacaguuucuauggggcguaggccucccaaaagguaacggaggcgugcaaagguuuccucgggccggacggagauuggcccucgagugcaaaggcagaagggagcuugacugcaagacccacccgucgagcagggacgaaagucggccuuagugauccgacggugccgaguggaagggccgucgcucaacggauaaaaguuacucuagggauaacaggcugaucuuccccaagaguucacaucgacgggaagguuuggcaccucgaugucggcucuucgccaccuggggcuguaguauguuccaaggguugggcuguucgcccauuaaagcgguacgugagcuggguucagaacgucgugagacaguucgguccauauccggugugggcguuagagcauugagaggaccuuucccuaguacgagaggaccgggaaggacgcaccucugguguaccaguuaucgugcccacgguaaacgcuggguagccaagugcggagcggauaacugcugaaagcaucuaaguaguaagcccaccccaagaugagugcucuccua ..............<<<<<<<<<<.....<<..<<<<<<<<<<<........<<<<<<.....((.>>>.....<<<<<<.<.<<.))......>>.....>>>>>>>...>>>....<<<....>>>........<<<<<<.........>>>>>>..........<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..................<<<.<<<..<<<....<.<<.....>>.>.((......<<<.....))>>>...>>>....>>>.>>>.................<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>........<<<<..<.<<<......>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.......>>...>>>...<<....>>..<<<<.....>>>>....>>>>>>>>>>>>>..<<.<...<<<<<<.......<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>.....<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<.<<<<<<..<<<<<<<<.<.....<<...<<<<<<<<<.................>>>>>>>>>..>>.......>>>>>>.>>>...>>>>>>..>>..<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<...<<<<.<<<<.....<.<.<<<.<<....<<.........>>....>>.........<<......>>...>>>.>.>.>>>.>>>>>..>>..........))).....>>>>>>.>>>...>>>>>>><<<<<......>>>>>....>>>>>>..<<<<<...........<<<<<<.<<....>>>>>>>>........>>>>>........>>>>>><......<<......<<<<<.......>>>>>.<<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>....<<<<........>>>>.))<<<<<.<<<<<<....<<<<.....<.<<..<...<<<<<<<<<<.....[[[..>>>>><...<<<<.....<<.<<<<<.......>>>>>...>>....>>>>....><..<<<<<....>>>>>...>>>>>>....>....>>>..........>>>>.....>....>>>>>..>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<..<<...............<<<<<...............>>>>><<<<<<.......>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<..<<<<<<...<<<....>>>....>>>>>>..>>...>>>>>>>>..>>>>><<<<<.........>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>.....>>..>>>>>>>.>>>>>>.....>.....<<<<..........>>>>..<<<<<<<<.<<...<......<<<<.<<<<<<..<<<<...<<<<<<<..<<.<<<.<<<<<<<<<...........<<......<.......<<.<<<<.......>>>>.>>....>...............>>..>>>>>>>>>.>>>.>.>..<<.<..<<<..........>>>..>>>.....>>>>>>>....>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>........<<<<..<<<<<<...<<.......>>...>>>>>>...>>>>.........<.<<<.<.<<<...<<<<<<<<........>>>>>..>>>..<<<.......>>>.......>>>...>...>>>..>....<<<<<<<....>>>.>>>>....>....>>>>>>>>>>....<<<<<<<...<.<<...<<<<<<...............>>>>>>..<<<<<...<<<<...<<<<<<<<<<<]]].>>>>>>...>>>>>...>>>>.>>>>>....<<...<<<<...............>>>>...>>..>>.>.......>>>>>>>.... ...............((((((((......(.....(((((((((.........(((((.....[[.))).....((((((......]]..............))))))...)).....(((....))).........(((((.........)))))...........((((((.....(...[..)......))))).).........(......)...((((......((.]...)).....))))...(((...................((.((((.(((....(.(.......).).[[......(((.....]])))...)))...)))).))...................((((((...........)))))).......(((((..[[[[)))))..)))......)).)))))))..................((....)).....).........((((....))))...................)))))))).........((((..(.(((......))))..))))..................((((......(.((.((((.(((..((....((.......))....))...(......)..((((.....))))....))).)))).)).)..((.(...((((((.....(.((((((((.((((...((((((......))))))...).)))...((..(((((........))))).))..).))))))).)...((.......))......))))))......).))..((((((....((((......)))).(.(..(((..(((((((.(.....(.(...(((.(((.....................))).)))..)..).....).)))).)))...)))..)..)...((((((((((......))))))))))....(((......)))....((..((....((([[[.....((((((...........((......(...((.......(.(((.((....((.........))....)).........((......))...))).)...))...).....))..........]]].....)))))).)))....)).))..(((........))).....))))))..((((((....(.....((((((.((....))))))))...)...))))))..........))))(......((.......((((.......))))..((((....((((..((....(((((...((.....)).))))).....[.(((.......(.(....((....))....).)........(((((........))))).]((((..((((.(....(.((.....(((..(((..(((((.((((.....{{{..)))).(.....(......((.(((.(.......).)))...)).....)......)(..(((((....)))))...))))))...)))...)))..........)).).....).....))))...)))).)))..)).....((......)).)))).((((.....))))..))))..((((....((((((((.(...(.............((((....(....).....)))).((((((.......))))))(...).......((((...((...((.........))...(((((((.....(.(....).).......)))))))..(((...((..(((((((..(((...((.....((......(....).......)).....))...))))))))..)))).(((((.........)))))........(............((((.......))))......).....)))...))....))))....).).)))))))).)))))).....).....(((.(........).)))..(((((((...((..(......(((..(((((...(((((..((((.((.....((..((((.((((............((.....(.......((.(.((.......)).).))....)..............))...)))).))))..))......((....(..............)...)).....)).))))...)))))..(((......[)))((((((..........])))))).[((....(((.((...((((...........)))).....(.][..[[.)....)).)))....((((...((...{..))...))))..((....))..))]]..].....(((.(((.((..]]]]..))))).)))......}.......)))..)).)))......(((((...((((((...((.......))...))))))....))).).).....(((((.(.((((..((.(((((........)))))...))...((.......)).......))))...)...))).))....((.(.((....))..).))....)...))..)))))))....((((((....(.((..(((((((.....(....)....)))))))..((((...((((...((.(.((((((}}}.))))))....).))...)))).)))).....((....(.(...............).)....))..)).)........)))))).... Homology model for the Spinach chloroplast 30S subunit fitted to 9.4A cryo-EM map of the 70S chlororibosome.; 23S rRNA 4v61 BB 117 9.4 RF00001 URS000080E36A_3562 18042701 0003735 0005840 3562 uucugguguccuaggcguagaggaaccacaccaauccaucccgaacuuggugguuaaacucuacugcggugacgauacuguaggggagguccugcggaaaaauagcucgacgccagg .<<<<<<<......<<<<<<<<.....<<.<.................>...>>....>>>>>>.>><<<.......<<<<<<<......>>>>>>>.......>>>...>>>>>>> .(((((........((((((.(.....((.(.................)...))....).)))).)).(........((..(((......)))..))........)......))))) Homology model for the Spinach chloroplast 30S subunit fitted to 9.4A cryo-EM map of the 70S chlororibosome.; 5S rRNA 4v61 BC 103 9.4 RF02541 URS0000525FC8_3562 18042701 0003735 0005840 3562 gaaggucacggcgagacgagccguuuaucauuacgauaggugucaaguggaagugcagugauguaugcagcugaggcauccuaacagacccacagacuugaac ...<<<.<<<<<.......>>>>>.............<.<<<<<.<<<.....<<<<....>>>>....>>>..>>>>>..>.....>>>............. ...((..((.((.......)).)).............(.(((....((....((.((....)).))...)).....)))..)......))............. Homology model for the Spinach chloroplast 30S subunit fitted to 9.4A cryo-EM map of the 70S chlororibosome.; 4.8S rRNA 4v63 AA 1504 3.207 RF00177,RF01959,RF01960 URS000080E323_262724 18596689 0003735 0005840 262724 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgaggaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<..<<<.....>.>>.>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>....<<<<.<<<<<....>>>>>.>>>>...<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<<....>>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<<..>>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((.........)))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((......(.]]])........))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((((..(((((((....)))))))...((((....))))..))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...(...(((.....)))).....)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Structural basis for translation termination on the 70S ribosome.; 16S RRNA 4v63 AZ 77 3.207 RF00005 URS000041AF00_562 18596689 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Structural basis for translation termination on the 70S ribosome.; P and E-site tRNA(fMet) 4v63 AV 12 3.207 18596689 aaaaauguaaaa ............ ............ Structural basis for translation termination on the 70S ribosome.; mRNA 4v63 AY 77 3.207 RF00005 URS000041AF00_562 18596689 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Structural basis for translation termination on the 70S ribosome.; P and E-site tRNA(fMet) 4v63 BA 2879 3.207 RF02540,RF02541,RF00002 URS000080DF36_262724 18596689 0003735 0005840 262724 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgucuaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaaaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagcuccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagacuacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.....>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.......<.<<......>>.>.>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<.<.....(...<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>..........).>>>>>>.>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<<..<<.......>>>..>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<<.....>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((....(((((((.(.((((((......)))).)))..)))))))...)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{..((((.(((..(((.........)))..))).....(...((......)).).))))....)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.((...{{....))))))(((...((((((((((((((((.((.....)))))))))....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((.((((((.(.........(((((..(((......((((((((....))))))))...)))............)))))).)))))).)))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...((((((....((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..].....))))))...(((.....))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Structural basis for translation termination on the 70S ribosome.; 23S RRNA 4v63 BB 119 3.207 RF00001 URS000080E212_262724 18596689 0003735 0005840 262724 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<<....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>> .((((((((((....((((((.(....(((((((...(.....)...))))..)))...).)))).))(((.......((.(((((....))))).)).......))).)))))))))) Structural basis for translation termination on the 70S ribosome.; 5S RRNA 4v63 CA 1504 3.207 RF00177,RF01959,RF01960 URS000080E323_262724 18596689 0003735 0005840 262724 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgaggaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<..<<<.....>.>>.>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>....<<<<.<<<<<....>>>>>.>>>>...<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<<....>>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<<..>>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((.........)))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((......(.]]])........))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((((..(((((((....)))))))...((((....))))..))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...(...(((.....)))).....)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Structural basis for translation termination on the 70S ribosome.; 16S RRNA 4v63 CZ 77 3.207 RF00005 URS000041AF00_562 18596689 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Structural basis for translation termination on the 70S ribosome.; P and E-site tRNA(fMet) 4v63 CV 12 3.207 18596689 aaaaauguaaaa ............ ............ Structural basis for translation termination on the 70S ribosome.; mRNA 4v63 CY 77 3.207 RF00005 URS000041AF00_562 18596689 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Structural basis for translation termination on the 70S ribosome.; P and E-site tRNA(fMet) 4v63 DA 2879 3.207 RF02540,RF02541,RF00002 URS000080DF36_262724 18596689 0003735 0005840 262724 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgucuaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaaaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagcuccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagacuacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.....>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.......<.<<......>>.>.>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<.<.....(...<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>..........).>>>>>>.>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<<..<<.......>>>..>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<<.....>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((.(.((((((......)))).)))..))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{..((((.(((..(((.........)))..))).....(...((......)).).))))....)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.((...{{....))))))(((...((((((((((((((((.((.....)))))))))....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((.((((((.(.........(((((..(((......((((((((....))))))))...)))............)))))).)))))).)))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...((((((....((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..].....))))))...(((.....))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Structural basis for translation termination on the 70S ribosome.; 23S RRNA 4v63 DB 119 3.207 RF00001 URS000080E212_262724 18596689 0003735 0005840 262724 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<<....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>> .((((((((((....((((((.(....(((((((...(.....)...))))..)))...).)))).))(((.......((.(((((....))))).)).......))).)))))))))) Structural basis for translation termination on the 70S ribosome.; 5S RRNA 4v64 AA 1530 3.5 RF00177,RF01959,RF01960 URS00000ABFE9_562 18567815 0003735 0005840 562 ugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggauca ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<<....>>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<.<.......>>>.>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>..<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>....>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((((((((..)))))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(...(((((((.(.......))).)))).)...)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))...((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.....]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Crystal structure of the bacterial ribosome from Escherichia coli in complex with hygromycin B.; 16S ribosomal RNA 4v64 BA 117 3.5 RF00001 URS0000049E57_562 18567815 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggc <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>> (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))) Crystal structure of the bacterial ribosome from Escherichia coli in complex with hygromycin B.; 5S ribosomal RNA 4v64 BB 2841 3.5 RF02540,RF02541 URS00004B0F34_562 18567815 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaacaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauggaaguguggacgccagucugcauggcuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.<...<<<...<<<.<<<<.......>>>>.>>>..>>.>...>.>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<..<<....>>...>>>>>..>....>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<.....<<<<<<<<....>>>>>>>>....>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>.(<<...<<<<<<<...<<<<<<.......>>>>>>.....<<)..(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<<...>>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((...(((((((((.(...(((...(((.((((.......)))).)))..)).)...).)))))).)))...))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((..((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((.....{{{....)))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((((.(...((((((((....))))))))..).)))).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((...))))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Crystal structure of the bacterial ribosome from Escherichia coli in complex with hygromycin B.; 23S ribosomal RNA 4v64 CA 1530 3.5 RF00177,RF01959,RF01960 URS00000ABFE9_562 18567815 0003735 0005840 562 ugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggauca ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<<....>>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<.<.......>>>.>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>..<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>....>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((((((((..)))))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(...(((((((.(.......))).)))).)...)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))...((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.....]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Crystal structure of the bacterial ribosome from Escherichia coli in complex with hygromycin B.; 16S ribosomal RNA 4v64 DA 117 3.5 RF00001 URS0000049E57_562 18567815 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggc <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>> (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))) Crystal structure of the bacterial ribosome from Escherichia coli in complex with hygromycin B.; 5S ribosomal RNA 4v64 DB 2841 3.5 RF02540,RF02541 URS00004B0F34_562 18567815 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaacaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauggaaguguggacgccagucugcauggcuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.<...<<<...<<<.<<<<.......>>>>.>>>..>>.>...>.>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<..<<....>>...>>>>>..>....>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<.......<<<<<<......>>>>>>......>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>.(<<...<<<<<<<...<<<<<<.......>>>>>>.....<<)..(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<<...>>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((...(((((((((.(...(((...(((.((((.......)))).)))..)).)...).)))))).)))...))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((..((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((.....{{{....)))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((((.(...(((((((......)))))))..).)))).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((...))))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Crystal structure of the bacterial ribosome from Escherichia coli in complex with hygromycin B.; 23S ribosomal RNA 4v65 AA 75 9.0 RF00005 URS000011107D_562 0030533 0006412 562 gcggauuuagcucaguugggagagcgccagacugaagaucuggagguccuguguucgauccacagaauucgcacc <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>... .((((((..((((.....[..)))).((((.........)))).....(((((..]....))))))))))).... Structure of the E. coli ribosome in the Pre-accommodation state; A/T, P and E-site tRNAs 4v65 AP 75 9.0 RF00005 URS000011107D_562 0030533 0006412 562 gcggauuuagcucaguugggagagcgccagacugaagaucuggagguccuguguucgauccacagaauucgcacc <<<<<<<..<<<<........>>>>.<<<<.........>>>>.....<<<<<.......>>>>>>>>>>>>... (((((((....((........))...((((.........)))).....(((((.......))))))))))))... Structure of the E. coli ribosome in the Pre-accommodation state; A/T, P and E-site tRNAs 4v65 AE 76 9.0 RF00005 URS000011107D_562 0030533 0006412 562 gcggauuuagcucaguugggagagcgccagacugaagaucuggagguccuguguucgauccacagaauucgcacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... .((((((..((((.....[..)))).(((((.......))))).....(((((..]....)))))))))))..... Structure of the E. coli ribosome in the Pre-accommodation state; A/T, P and E-site tRNAs 4v65 AM 20 9.0 562 uuuuuuuuuuuuuuuuuuuu .................... .................... Structure of the E. coli ribosome in the Pre-accommodation state; mRNA model 4v65 A1 1530 9.0 RF00177,RF01959,RF01960 URS000080E24C_562 0003735 0005840 562 ugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggauca ............<<<............<<<<...<<<<<<<......<<<.<<<...<..........<<<<<<<<<<....>>>>>>>.>>>.......>.......<<........<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>.<<<....<<<...<<<<<.<........>>>>>>.>>>......>>>..<<<<<<........>>...>>>>.>>.<<<<.<<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<..................>>>...>.>>>>>>..<<<<.......<<......>>......>>>>...<.<<<<<......<<<<<<<<.<.......>>>.>>>>.>>.......>>>>>....>..<<<<<......<<<<......................>>>>>>>>>...>>>>.........................<.<...<<<..<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>....<<<<<<<<...<<<<<.<.....<<<<<<<.....................>>>>>>>.............<....>..>.>>>>>..>>>>.>>>>...>>>...>.>......<<<.<...<<...<<<<.........>>>>...>>.>>>>.............<<....<<<<<<<<<<<<.....>>>>>>>>>>>>..................>>........<........<<<....>>>......>....>>>........<<.<<<<.<<.<<<.....<<<<<.<.<<.......<........>...........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<......<<<<<<.........<.<.............<<<<......>>>>...>.>.......<<<..<<<<<<....<...<<<.....>>>.>.....>>>>>>.....<<<<<.....>>>>>.........>>>.........>>>...>>>...>>>...>>>>>>>...>>..>.>>>>>......<<<<<<......<...<<...<<<....>>>...>>.....>......>>>>>>............<<<<<<..........>>>>>>.............>>>.....<<<<<<.........>>>>>>.......>>...>>>>.>.>..................<<...<....<<<<.<<<.......<<<<<<.<<<...<<....>>..>>>>>>>>>......>>>.>>>>....>...>>...................<..............>......... .............(.............((((...(((..((((....(....((....(......(..(((((.(((.(..).))).)).)))).....)........(........(.(.(((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....(((((...((....)).))))).)))))))..)).))).).)(((....(((..(((((..(........).))))))))......)))....(((..(.....).)...))....).(((((............))))).((((....))))...))...).).....(.((....................))).)).)..)))..((((.......(((....)))......))))...(.(((((......((((((((.(.......))).)))).)).......)))))....)..((...[.....(((((.....(....].).......)))))...))...))))..............(............(...(((...(((((.((((((((((......((((((.....))))))....))))))))..)))))))....((((((((.....(((.((.....(..(((....((........)).......)))..).............(....)..)).)))....))).))))..))))...)........(((.((...(...(.(...........).)...).))))).............((.....(((((((((((.....)))))))))))...................)).....)...(........((....))......)......)..........(.((((..(..((.(....((((............(........)...........((.((((......((((((...(((((((....)))))))...((....))...)))).))..(..(.(...((.(((.(.......(...............(((......))).....).........(((..((((((.......(((.....)))......))))))...(..(((((.....))))).....)..)))......).).))....))..)).)....)))).)).........))))..(....((((((.....(.(..((...(((....)))...))....).).....))))).)...........((((((..........)))))).......)....))).......(..((.........))..)........)....)))).)..............(......(..(......((((.......(..((.(((.......((....)).....))).))).......).))).......).).......)..................................... Structure of the E. coli ribosome in the Pre-accommodation state; 16S rRNA 4v65 BA 117 9.0 RF00001 URS000080DF7E_562 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggc <<<<<<<<......<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<.........<<<<<<.....>>>>>>.........>....>>>>>>>> (((((((((.....((((((((.....(((.((...(.....)...)).)..))....)))))).)).((........((((((.....))))))........))...))))))))) Structure of the E. coli ribosome in the Pre-accommodation state; 5S rRNA 4v65 BB 2903 9.0 RF02540,RF02541 URS000080E25C_562 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu 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((((((((..........((((............((((((..(((((......((.....................(((.....(((......).)).........))).....))....((......)).(((.((....)).)))..(((((((((.........))))))))).))...((((.(......(......)......)))).).........((....))...(((((..................)))))...((((.((((......((((((((((((..(((...((((........)))).[......(((.....].)))...)))...).)))))))))))...))))...)....((..((.............))..))......(.(((..{{..)).))..)))......)).)..)))).))......................................((((.....)))).....................))))..............(.....((......))......).....(.............)..........(........(......(....((.....)).....)...((....))..(((.......)))........)........).........(.................(......(...((.(((......))).))...)......................................)..........(........)...........)............((((((....(............)...((((((...((((((((.(....(.(...((...((....(((((((.....))))).))....))...))..)..).....)))))).)))...))))))..........(.((..........))..).......................(...((.....((........((((((............(..(((((..(((.......(((((..((..(((.........)))..))......(...((......)).).)))))...)))..))))).)....................)))))).).)....))...)..(((((((....)))))))......)))))).....((....((..........(.((....)).).......))...))...............................(.((((.......)))).)(.((.......(.........((.(.............).).).....(..{........(((...(((....)))...)))..........((..........))...)(((((((((((((...((((.....((...(((..(((((..((((....[[....))))..((..(((....(.((((((((((.((.....))))))))))..)).)..[.)))...))(..(((((....)))))...))))))...)))....).)(..).....))))...))....)))))))))))..}......................)...(...........)..)).)...(.(.................(............(.((.....(....)......)).)((((((.....(((...(((((..)]))))...)))...))))))(...).......(..((...........................((......(........)........))......(.((.........((((.............(((((..((....))...)))))...........))))........(..((.........))..)..........(...............................)....)).)........).).)....).............))..................................((((.(..................(......(....(...(((..((((....((((((((..((.........[..(((((.....(.......((((((....)))))).....)............].)))))...))..))))))))......(((.((((.(.....).)))))))....))))..))).....).....(.......)...(((((...........))))).(..(...((..(......(((.(........)))).............[........)..))...((((..(((......)))..))))...(....)...).].............(((.((....}}..))))).........).......).......)..................(((((.................)))))............................(......(((((......)).)))......(...(.....)....)....)....................((...............)).............).))))....(((((.(...(((.....(((((.....(....)....)))))......(.....(((.....(((...((..]]..)).....))).....)))...)......(((....((((.............))))....)))..))).......).)))))(.((((((...)))))).....((...((...........)).....(.(.(((((.((....(((((....)))))...)))..))))..).).....))....))))))))). Structure of the E. coli ribosome in the Pre-accommodation state; 23S rRNA 4v66 AA 75 9.0 RF00005 URS000011107D_562 0030533 0006412 562 gcggauuuagcucaguugggagagcgccagacugaagaucuggagguccuguguucgauccacagaauucgcacc <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>... (((((((..((((.....[..)))).((((.........))))......((((..]....)))).)))))))... Structure of the E. coli ribosome and the tRNAs in Post-accommodation state; A/T, P and E-site tRNAs 4v66 AP 75 9.0 RF00005 URS000011107D_562 0030533 0006412 562 gcggauuuagcucaguugggagagcgccagacugaagaucuggagguccuguguucgauccacagaauucgcacc <<<<<<<..<<<<........>>>>.<<<<.........>>>>.....<<<<<.......>>>>>>>>>>>>... (((((((...(((........)))..((((.........)))).....(((((.......))))))))))))... Structure of the E. coli ribosome and the tRNAs in Post-accommodation state; A/T, P and E-site tRNAs 4v66 AE 76 9.0 RF00005 URS000011107D_562 0030533 0006412 562 gcggauuuagcucaguugggagagcgccagacugaagaucuggagguccuguguucgauccacagaauucgcacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... .((((((..((((.....[..)))).(((((.......))))).....(((((..]....)))))))))))..... Structure of the E. coli ribosome and the tRNAs in Post-accommodation state; A/T, P and E-site tRNAs 4v66 AM 20 9.0 562 uuuuuuuuuuuuuuuuuuuu .................... .................... Structure of the E. coli ribosome and the tRNAs in Post-accommodation state; mRNA model 4v66 A1 1530 9.0 RF00177,RF01959,RF01960 URS000080E24C_562 0003735 0005840 562 ugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggauca ............<<<............<<<<...<<<.<<<......<<<.<<<...<..........<<<<<<<<<<....>>>>>>>.>>>.......>.......<..........<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>..<<<....<<<...<<<<<.<........>>>>>>.>>>......>>>..<<<<<<........>>...>>>>..>.<<<<.<<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<.....<<......>>...>>>...>.>>.>>>..<<<<.......<........>......>>>>...<.<<<<<...<..<.<<<<<<.<.<...>.>>>.>>>>.>>.......>>>>>....>..<<<<<......<<<<......................>>>>>>>>>...>>>>.........................<.....<<<..<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>....<<<<<<<<....<<<<<<.....<<<<<<<...<..........>......>>>>>>>.............<....>..>>>>>>...>>>>.>>>>...>>>.....>.....<<<<.<...<<...<<<<.........>>>>...>>.>>>>>............<<....<<<<<<<<<<<<.....>>>>>>>>>>>>..................>>.................<<<....>>>...........>>>.........<.<<<<.<<.<<<.<....<<<<.<...............................<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>..<<......<<<<<<.........<<<..............<<<......>>>....>>>.......<<<..<<<<<<....<...<<<.....>>>.>.....>>>>>>.....<<<<<.....>>>>>.........>>>.........>>>...>>>...>>....>>>>>>>.......>.>>>>.......<<<<<<......<<..<<...<<<....>>>...>>....>>......>>>>>>............<<<<<<..........>>>>>>...........>.>>>.....<.<<<<.........>>>>.>.......>>...>>>>..>...................<....<....<<<<<<<<.......<<<<<<.<<<...<<....>>..>>>>>>>>>......>>>>>>>>....>....>...................<..............>......... .............(.............((((...((((.((((....(....((....(......(..(((((.(((.(..).))).)).)))).....)........(........(.(.(((...(...(((((((.(.((.....((((((....))))))......)).).....(((....)))....(((((...((....)).))))).)))))))..)..))).).)((.....(((..(((((((.........)))))))))).......))....(((..(.....).)...))....).(((((.(.........)))))).((((....))))...))...).).....(.((.......(......).....))).)).).))))..((((.......(((....)))......))))...(.(((((......((((((((.(.......))).)))).)).......)))))....)..((...[.....(((((.....(....].).......)))))...))...))))..............(............(...(((...(((((.((((((((((......((((((.....))))))....))))))))..)))))))....(((((((((....(((.(((....(..(((....((........)).......)))..)....)........(....)..)).)))...)))).))))..))))...)........(((.((...(...(.(...........).)...).))))).............((.....(((((((((((.....)))))))))))...................)).....)...(......(.((....)).)....)......)..........(.((((..(..((.(....((((............(........)...........((.((((......(.((((...(((((((....)))))))...((....))...))))..)..((.(.(...((.(((.(.......(...............(((......))).....).........(((..((((((.......(((.....)))......))))))...(..(((((.....))))).....)..)))......).).))....))..))))....)))).)).........))))..(....((((((......((..((...(((....)))...))....))......))))).)...........((((((..........)))))).......)....))).......(..((.........))..)........)....)))).).........(....(.....((.........(((..(.....(..((.(((.......((....)).....))).)))......)..))).........))......)......).............................. Structure of the E. coli ribosome and the tRNAs in Post-accommodation state; 16S rRNA 4v66 BA 117 9.0 RF00001 URS000080DF7E_562 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggc <<<<<<<<......<<<<<<<<.....<<<<<<.............>>>>..>>....>>>>>>.>>.<.........<<<<<<.....>>>>>>.........>....>>>>>>>> (((((((((.....((((((((....((((.((...(.....)...)).)..)))...)))))).)).((........((((((.....))))))........))...))))))))) Structure of the E. coli ribosome and the tRNAs in Post-accommodation state; 5S rRNA 4v66 BB 2903 9.0 RF02540,RF02541 URS000080E25C_562 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<.......<<.<<<<.<..........<<<<<<<<<<.<<......<<<...................<<<<<....<<<.......>>>........>>>>>...>>>....<<......>><<<<<<<....>>>>>>>.<<<<<<<<<<......>.>>>>>>>>>.>>...<<<<.<....................>>>>..>........<<....>>...<<<<<..................>>>>>...<<<..<<<<......<<<<<<<<<<<...<......<<<........>>>.........<<<.......>>>.....>.....>>>>>>>>>>>...>>>>........<...<<.............>>...>.......<<<<..(((.>>.>>..>>>.......>.>>>>>>>.>>......................................<<<<.....>>>>...................>.>>>>.>>.........<<....<<<<......>>>>....>>...................<<........<<.....<<<<<<....<...<<.....>>...>.....<<....>>..<<<.......>>>.....>>>>>>.....>>..<<.....<<<...............<....<<<...<<<<<<......>>>>>>.>>...>...................................>.........<<.......>>.........>>>........>>..<<<<<........<<....>>.....<<<<<<<...<<<<<<<<.<....<<<...<<..<<<<...<<<<<<<.....>>>>>.>>...>>>>..>>..>>.>.....>>>>>>.>>>...>>>>>>>..........<..<........>..>........................<<<<.<<........(......<<<<<<...........<<...<<<<..<<......<.<<<<<.<<<..<<<.........>>>..>>>........<<<......>>>..>>>>>.>..>>..>>>>..>>............)......>>>>>>........>>>>>>.<<<<<<<<....>>>>>>>>......>>>>>.<..<<<....<.............<<....>>..........>...>>>...>..........>>................<<<<.......>>>>..<<<<...............<<<<<...............>>>>.>.....<<..<<<...<<<...<<<....>>>...>>>...>>>..<<<<..........>>>>..<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<.<<<<<....[[....>>>>>.....<<<.....<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>.....>>>........<<<<<....>>>>>....>>>>>...>>>...>>.>>........>>>>...>>....>>>>>>>>>>>..>>.........................<<.........>>..>>>>...<<.........<<......................<<.................>>..<<<<<<.....<.<...<<<<.....>>>>...>.>...>>>>>>............<.<.<<.........................<<<<......................>>>>.....<<<<...<....<<<<<..<<.........<<<<<<.<<....>>..>>>>>>.........>>>>>>>.....>.<<<<<<.......>>>>>>......................<...........>............>>>>.......>>.>.>..........>>......>>..................................<<<<.<........................<<....<...<<<.<<<<..<<<<<<<<<<<.<<<............<<<<<..<<.......<<<<<<<......>>>>>>>....>>............>>>>>...>>>.>>>>>>>>>>>...<<<.<<<<<.......>>>>>>>>.....>>>>.>>>....>....<<<.......>>>.<<<<<...........>>>>>........((.[((.....<<<<.........>>>>...........<<<.......)).]))...<<<<...<<<....>>>...>>>>..............>>>........<<<<<<.<<...)))..>>>>>>>>..............>>..................<......<<<<<...<.........>...>>>>>.......>..........<..<.........<<<..<<<<......>>.>>...>>>..<<<.......>>>.................>....>....<<..<<......>>...>>.............>.>>>>....<<<<<<<...<<<<...<<<<<<...............>>>>>.>..<<<<....<<<.....<<<..<<<..]]..>>>....>>>.....>>>..>>>>.....<<....<<<<<...........>>>>>....>>..>>>>.......>>>>>>>..<<<<<<...>>>>>>.....<<.......................<..<<<<<..<<....<<<<<....>>>>>...>>...>>>>>...>.....>>.....>>>>>>>>. ((((((((..........((((............((((((...((((......((.....................(((.....(((......).)).........))).....))....((......)).((((((....))))))..(((((((((.........))))))))).))....(((.(....................))))...........((....))...(((((..................)))))...((((.((((......(((((((((((...(((...((((.(.....))))).[......(((.....].)))...))).....)))))))))))...))))...)....((..((.............))..))......(.(((..[[..)).))..)))......))....)))).))......................................((((.....)))).....................)))).......(......(.....((......))......)..............................(........(.((...(....((.....)).....)...((....))..(.(.......).).....)).)........)..(......(.(...............(......(....(.(((......))).)....)......................................)..........(........).........).).........)..((((.(....(............)...((((((...((((((((.(....(.(...(((..((....(((((((.....))))).))....))..)))..)..).....)))))).)))...))))))..........(.((..........))..).......................(...((........[......((((((...........((..(((((..(((.......(((((..((..(((.........)))..))......(...((......)).).)))))...)))..))))).))............]......))))))........))...)..(((((((....)))))))......).)))).....((....((..........(.((....)).).......))...))...............................(.((((.......)))).)(.((.......(...(......(((.............))).......(..<........(((...(((....)))...)))..........((..........))...)(((((((((((((...((((.....(((..(((..(((((..((((....{{....))))..((..(((......((((((((((.((.....))))))))))..))....[.)))...))(..(((((....)))))...))))))...)))...)).)(..).....))))...))....)))))))))))..>....).................)...(...........)..)).)...(.(.................(..........(.(.((.....(....)......)).)((((((.....(((...(((((..)]))))...)))...))))))(...).......(..((...........................((......(........)........))......(.(..........((((.............(((((..((....))...)))))...........))))........(..((.........))..)..........(...............................).....).)........).).))...).............))................................)..(((.(..................(......(....(...(((.(.(((.(..((((((((..((.........[..(((((.....(.......((((((....)))))).....)............].)))))...))..))))))))...)..(((.((((.(.....).)))))))....)))..)))).....).................(((((...........))))).(..(...((..(......(((.(........)))).............[........)..))...((((..(((......)))..))))...(....)...).]..........(..(((.((....]]..)))))..)......).......).......)..................(((((...(.........)...)))))............................(......(((((......)).)))......(...(.....)....)....)....................(.................).............).))).....(((((.(...((((....(((((.....(....)....)))))......(.....(((.....(((...((..}}..)).....))).....)))...).......((....((((.............))))....))..)))).......).)))))(.((((((...)))))).....((...((...........)).....(.(.(((((.((....(((((....)))))...)))..))))..).).....))....))))))))). Structure of the E. coli ribosome and the tRNAs in Post-accommodation state; 23S rRNA 4v67 AA 1504 3.0 RF00177,RF01959,RF01960 URS000080E323_274 19064930 0003735 0005840 274 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgaggaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<<.....>>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<<....>>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.....)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(.(((....))).).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..((((((((....((((((((....((((((....((........)).......))))))....).......((....)).)))))))...)))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((.(..((((((((((......((........))..........(((((((..(...((((((((..(((.(((....))).)))...((((....))))..))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..((...(((.....)))).)...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..).))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Crystal structure of a translation termination complex formed with release factor RF2.; 16S RRNA 4v67 AZ 77 3.0 RF00005 URS000041AF00_562 19064930 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of a translation termination complex formed with release factor RF2.; P AND E-SITE TRNA(FMET) 4v67 AV 10 3.0 19064930 262724 aauguaaaaa .......... .......... Crystal structure of a translation termination complex formed with release factor RF2.; MRNA 4v67 AY 77 3.0 RF00005 URS000041AF00_562 19064930 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(.(((..]....))).)))))))..... Crystal structure of a translation termination complex formed with release factor RF2.; P AND E-SITE TRNA(FMET) 4v67 BA 2879 3.0 RF02540,RF02541,RF00002 URS000080DF36_274 19064930 0003735 0005840 274 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgucuaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaaaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagcuccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagacuacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.....>>>>>>.>>....<<<<<.....<......>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..<<<<.......>>>>..>>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>....>>>>>>>>>..>>>....<<<<....>>>>......>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<<..<<.......>>>..>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<<.....>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> .((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((.(.((.(((......)))..)))..)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((..(((.........)))..))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.((...{{....))))))(((...((((((((((((((((.((.....)))))))))....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........(((((..(((......((((((((....))))))))...)))............)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))...(((.....))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....)). Crystal structure of a translation termination complex formed with release factor RF2.; 23S RRNA 4v67 BB 119 3.0 RF00001 URS000080E212_274 19064930 0003735 0005840 274 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).)))))))))) Crystal structure of a translation termination complex formed with release factor RF2.; 5S RRNA 4v67 CA 1504 3.0 RF00177,RF01959,RF01960 URS000080E323_274 19064930 0003735 0005840 274 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgaggaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<<.....>>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<<....>>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.....)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(.(((....))).).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..((((((((....((((((((....((((((....((........)).......))))))....).......((....)).)))))))...)))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((.(..((((((((((......((........))........(.(((((((..(...((((((((..(((.(((....))).)))...((((....))))..))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..((...(((.....)))).)...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..).))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Crystal structure of a translation termination complex formed with release factor RF2.; 16S RRNA 4v67 CZ 77 3.0 RF00005 URS000041AF00_562 19064930 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of a translation termination complex formed with release factor RF2.; P AND E-SITE TRNA(FMET) 4v67 CV 10 3.0 19064930 262724 aauguaaaaa .......... .......... Crystal structure of a translation termination complex formed with release factor RF2.; MRNA 4v67 CY 77 3.0 RF00005 URS000041AF00_562 19064930 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(.(((..]....))).)))))))..... Crystal structure of a translation termination complex formed with release factor RF2.; P AND E-SITE TRNA(FMET) 4v67 DA 2879 3.0 RF02540,RF02541,RF00002 URS000080DF36_274 19064930 0003735 0005840 274 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgucuaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaaaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagcuccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagacuacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.....>>>>>>.>>....<<<<<.....<......>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..<<<<.......>>>>..>>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>....>>>>>>>>>..>>>....<<<<....>>>>......>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<<..<<.......>>>..>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<<.....>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> .((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((.(.((.(((......)))..)))..)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((..(((.........)))..))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.((...{{....))))))(((...((((((((((((((((.((.....)))))))))....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........(((((..(((......((((((((....))))))))...)))............)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))...(((.....))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....)). Crystal structure of a translation termination complex formed with release factor RF2.; 23S RRNA 4v67 DB 119 3.0 RF00001 URS000080E212_274 19064930 0003735 0005840 274 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).)))))))))) Crystal structure of a translation termination complex formed with release factor RF2.; 5S RRNA 4v68 AA 1504 6.4 RF00177,RF01959,RF01960 URS000080E260_274 19229291 0003735 0005840 274 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<...<........>..>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<.<<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<.<...<<<<<<<....>>>>>>>...<<<<....>>>>....>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<....<<.....>>..>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<...<<<<....>>>>...>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.((...(((..((.((((..(...........)..)))).)))))......(((......((((((((..((...(((((((.(((((....(((..(....)..))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))....))))).).....(.(((...(.(.(....).)..))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((....((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..)))....))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((.(..((((((((((......((........))..........(((((((..(...(((((.....(((((((....)))))))....................)))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(.(((((........................))))).)..(..((..(....)..)).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..).))).....(((((((..........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. T. thermophilus 70S ribosome in complex with mRNA, tRNAs and EF-Tu.GDP.kirromycin ternary complex, fitted to a 6.4 A Cryo-EM map.; 16S rRNA 4v68 AV 77 6.4 RF00005 URS000041AF00_274 19229291 0030533 0006412 274 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... T. thermophilus 70S ribosome in complex with mRNA, tRNAs and EF-Tu.GDP.kirromycin ternary complex, fitted to a 6.4 A Cryo-EM map.; P-SITE TRNA 4v68 AW 76 6.4 RF00005 URS00005AA258_274 19229291 0030533 0006412 274 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((........)))).((((.........)))).....(((((.......)))))))))))).... T. thermophilus 70S ribosome in complex with mRNA, tRNAs and EF-Tu.GDP.kirromycin ternary complex, fitted to a 6.4 A Cryo-EM map.; E-SITE TRNA 4v68 AY 72 6.4 RF00005 URS000080DE32_274 19229291 0030533 0006412 274 gcggauuuancucaggagagcnccaganunaagaunuggagnucnugugnucgnuccacagaauucgcacca <<<<<<<..<<<<....>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((..[.)))).((((.........)))).....(((((..]....)))))))))))).... T. thermophilus 70S ribosome in complex with mRNA, tRNAs and EF-Tu.GDP.kirromycin ternary complex, fitted to a 6.4 A Cryo-EM map.; AT-SITE TRNA 4v68 BA 2852 6.4 RF02540,RF02541,RF00002 URS000080E13F_274 19229291 0003735 0005840 274 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucgggggcccucggccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcgccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<..>>>>>>.>>....<<<<<.....<<....>>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>.....<<<<<<<<.<.<<...<<<.<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>...>>>>..>>>.>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<....>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<...<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<.....<<....>>......>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<.........<<<<.<<.....................>>.........<........>...>>>>.....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>>.............>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<<.<<<<.....<<<<<<<<....>>>>>>>>..>>>>..........>>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<<..<<.......>>>..>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<.......>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> ((.......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((....))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....((((.(((((...(....((.(.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..).))...)..)))))..)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((((((((....)))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))..)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((.(....(....)....)..))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((((((.........(.((.(((..(((.........)))..)))(...)(...((......)).).)).).....))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.((...{{....))))))(((...(((((((((..(((((.((.....))))))).......)))))))))..)))(...........))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((.........))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((.(.((((.(.........(((((..(((......((((((((....))))))))...)))...........)))))).)))).).)))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))...(.........).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...)))).....)) T. thermophilus 70S ribosome in complex with mRNA, tRNAs and EF-Tu.GDP.kirromycin ternary complex, fitted to a 6.4 A Cryo-EM map.; 23S rRNA 4v68 BB 119 6.4 RF00001 URS000080DE2B_274 19229291 0003735 0005840 274 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<<....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>> .((((((((((....(((((.((....(((.(((...(.....)...)))...)))...)).))).))(((.......((.(((((....))))).)).......))).)))))))))) T. thermophilus 70S ribosome in complex with mRNA, tRNAs and EF-Tu.GDP.kirromycin ternary complex, fitted to a 6.4 A Cryo-EM map.; 5S rRNA 4v69 AA 1530 6.7 RF00177,RF01959,RF01960 URS000080E24C_562 19122150 0003735 0005840 562 ugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggauca ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<<....>>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<.......<<<<..>>>>......>>>>...<.<<<<<......<.<<<<<<.<.......>>>.>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<....<.<<<<<<.....>>>>>>.>..>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>.........<.<<<<<<<........>>>>>>>>.........>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((((((((..)))))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(...(((((((.(.......))).)))).)...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))...((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.....]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Ternary complex-bound E.coli 70S ribosome.; 16S rRNA 4v69 AY 76 6.7 RF00005 URS000011107D_562 19122150 0030533 0006412 562 gcggauuuagcucaguugggagagcgccagacugaagaucuggagguccuguguucgauccacagaauucgcacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((.........)))).....(((((..]....)))))))))))).... Ternary complex-bound E.coli 70S ribosome.; A/T-site tRNA Phe 4v69 AW 76 6.7 RF00005 URS00005AA258_562 19122150 0030533 0006412 562 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((........)))).((((.........)))).....(((((.......)))))))))))).... Ternary complex-bound E.coli 70S ribosome.; P-site tRNA fMet (Unmodified bases except for Thymine 54) 4v69 AX 11 6.7 19122150 32630 aaaaauguuca ........... ........... Ternary complex-bound E.coli 70S ribosome.; mRNA 4v69 AV 77 6.7 RF00005 URS000041AF00_562 19122150 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Ternary complex-bound E.coli 70S ribosome.; E-site tRNA Phe 4v69 BB 2903 6.7 RF02540,RF02541 URS000080E25C_562 19122150 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<<.....>>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<..<<....>>...>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<.<..........<<<<...........<<<<<<<<....>>>>>>>>..................>>>>.>.>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<<...>>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((...(((((((((.(...(((...(((.((((...(((((((.....))))).))...)))).)))..)).)...).)))))).)))...))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((..((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((((((((((...((((....((((..(((..(((((((((((....{{{...))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((((.(......[....(((..(........(((.((((....)))).))).....)..........].)))..).)))).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((...))))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Ternary complex-bound E.coli 70S ribosome.; 23S ribosomal RNA 4v69 BA 117 6.7 RF00001 URS000080DF7E_562 19122150 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggc <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.....<.<<<<<<<<...>>>>>>>>...>...>>...>>>>>>>>> (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))) Ternary complex-bound E.coli 70S ribosome.; 5S ribosomal RNA 4v6a AA 1495 3.1 RF00177,RF01959,RF01960 URS000080DD29_300852 19696344 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgcacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<...>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<........<<........>>..........<<<<<<<.......<<<<<<...<<<<<<<....>>>>>>>....<.......>.....>>>>>>..<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>.....>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((.........)))).)))))......(((......((((((((..((...(((((((.(((((....((((........)))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((....((........))..)))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..((((((((....((((((((....((((((....((........)).......))))))....).......((....)).)))))))...)))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((.....)))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((..(.......((........))..........(((((((.......(((..(.......(((....))).......................).)))...((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.((((.(..........................).)))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))...)...)))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((..........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Structure of EF-P bound to the 70S ribosome.; 16S ribosomal RNA 4v6a AW 77 3.1 RF00005 URS000041AF00_562 19696344 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Structure of EF-P bound to the 70S ribosome.; tRNA-Met 4v6a BA 2767 3.1 RF02540,RF02541,RF00002 URS00001698E8_300852 19696344 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagcaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccg .........<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<....>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<.......<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>...>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<..>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<.<.<<<<<<......>>>>.>>>..>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<..........>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><.........>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<....>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<.........>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>. .........((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((......))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((.(((........(...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)....)))..)))]....((((((((..[......))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((((((((())))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((.(.(((((........))).)))..))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((............)))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.((...{{....))))))(((...((((((((((..((((.((.....))))))..).....)))))))))..)))(.........))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((.(...((((.(......[..((((...................]..))))).))))...).)))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))...................(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...)))). Structure of EF-P bound to the 70S ribosome.; 23S ribosomal RNA 4v6a BB 119 3.1 RF00001 URS00005F2F4B_300852 19696344 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>> .((((((((((....((((((((....(((.(((...(.....)...)))...)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))) Structure of EF-P bound to the 70S ribosome.; 5S ribosomal RNA 4v6a CA 1504 3.1 RF00177,RF01959,RF01960 URS000080DD29_300852 19696344 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<<<<<<<.........>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<<....>>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<.<...<<<<<<<....>>>>>>>..................>.>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<<..>>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((((((...........))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((......((.(..(.....(.(.(....).).).....................).).))..((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...(..............).....))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((...((.((((....))))).).....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((..........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Structure of EF-P bound to the 70S ribosome.; 16S ribosomal RNA 4v6a CW 77 3.1 RF00005 URS000041AF00_562 19696344 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(.((...].....)).)))))))..... Structure of EF-P bound to the 70S ribosome.; tRNA-Met 4v6a DA 2777 3.1 RF02540,RF02541,RF00002 URS00001698E8_300852 19696344 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<....>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<.......<...<<<<..<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>...>>>>..>...>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<...<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<........>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<....................>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><.........>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<..<<<<...........<<<<<................>>>>>..>>>>..>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<.........>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> .........((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...((((((((.....))))))))....{.((((((((.......(...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)...))))).))))....(((((((((.[.....)))))))))....}.(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((.(((((.))))).))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))..)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((.(...(.(((((((....((...((..((((...(((.((......)).).))...))))..))..)).....))))))).)..)..))))))).)...(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(.((((.(.....................))))).).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.((...{{....))))))(((...((((((((((..((((.((.....))))))..).....)))))))))..)))(.........))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((........(.(......[..((((...............]..))))).)........)))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........])))))).[((...(((((((.(.((((...........))))...).((]..[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].......(((((((.((..]]]]..)))))))))......}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((.(..((((.............))))...)))).))))..]....)))))))...................(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....... Structure of EF-P bound to the 70S ribosome.; 23S ribosomal RNA 4v6a DB 119 3.1 RF00001 URS00005F2F4B_300852 19696344 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>> .((((((((((....((((((.(....(((((((...(.....)...))))..)))...).)))).))(((.......((((((((....)))))))).......))).)))))))))) Structure of EF-P bound to the 70S ribosome.; 5S ribosomal RNA 4v6c AA 1533 3.19 RF00177,RF01959,RF01960 URS000080E246_562 19696352 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggauca .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<.<<..>>.>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>...<.<<<<<......<.<<<<<<.<.......>>>.>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((((((((..)))))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((.(.......))).)))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))...((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.....]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Crystal structure of the E. coli 70S ribosome in an intermediate state of ratcheting; 16S rRNA 4v6c BA 2854 3.19 RF02540,RF02541 URS000080E25C_562 19696352 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauggaaguguggacgccagucugcauggcuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<.>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<.........>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<..<<....>>..>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<.....<<<<<<<......>>>>>>>....>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.(...(((...(((.((((...((((((.)))).))...)))).)))..)).)...).)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]]((((((((((.((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...)).....)))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((((.(...(((((((......)))))))..).)))).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Crystal structure of the E. coli 70S ribosome in an intermediate state of ratcheting; 23S rRNA 4v6c BB 118 3.19 RF00001 URS0000366A67_562 19696352 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))). Crystal structure of the E. coli 70S ribosome in an intermediate state of ratcheting; 5S rRNA 4v6c CA 1530 3.19 RF00177,RF01959,RF01960 URS000080E24C_562 19696352 0003735 0005840 562 ugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggauca ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<.<..>.>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<...<....>.>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<.<.......>>>.>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((((((((..)))))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(..(.((((((.(.......))).)))).)...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((..(((((((....)))))))...((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(.(..((...(((....)))...))....).).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.....]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Crystal structure of the E. coli 70S ribosome in an intermediate state of ratcheting; 16S rRNA 4v6c DA 2841 3.19 RF02540,RF02541 URS000080E25C_562 19696352 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaacaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauggaaguguggacgccagucugcauggcuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<........>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<.......>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<<..<<<.........>>>..>>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.......<<<<<..<<....>>...>>>>>.......>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<..<<<.<<<<<.<<<<<<<<<<<.<<<<.....<<<<<<<......>>>>>>>....>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>...>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<<...>>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((...(((((((((.(...(((...(((.((((.......)))).)))..)).)...).)))))).)))...))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.......(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((..((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((.....{{{....)))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((((.(...(((((((......)))))))..).)))).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..(....)..]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.((((((...))))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Crystal structure of the E. coli 70S ribosome in an intermediate state of ratcheting; 23S rRNA 4v6c DB 117 3.19 RF00001 URS000080DF7E_562 19696352 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggc <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>> (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))) Crystal structure of the E. coli 70S ribosome in an intermediate state of ratcheting; 5S rRNA 4v6d AA 1533 3.814 RF00177,RF01959,RF01960 URS000080E246_562 19696352 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggauca .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<.<<..>>.>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<........<<<<<<.<.......>>>.>>>>..........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>...<<<......>>>...>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((((((((..)))))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(...(((((((.(.......))).)))).)...)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))...((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.....]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Crystal structure of the E. coli 70S ribosome in an intermediate state of ratcheting; 16S rRNA 4v6d AV 17 3.814 URS000080E2A3_32630 19696352 32630 ucgggcucauaacccga <<<<<.......>>>>> (((((.......))))) Crystal structure of the E. coli 70S ribosome in an intermediate state of ratcheting; P-site tRNA ASL fragment 4v6d BA 2854 3.814 RF02540,RF02541 URS000080E25C_562 19696352 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauggaaguguggacgccagucugcauggcuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<.>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<.........>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>>.<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>.<..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>.>......>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<.....<<<<<<<......>>>>>>>....>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.(...(((...(((.((((...((((((.)))).))...)))).)))..)).)...).)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..(((((((((((....{{{...))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((((.(...(((((((......)))))))..).)))).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Crystal structure of the E. coli 70S ribosome in an intermediate state of ratcheting; 23S rRNA 4v6d BB 118 3.814 RF00001 URS0000366A67_562 19696352 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))). Crystal structure of the E. coli 70S ribosome in an intermediate state of ratcheting; 5S rRNA 4v6d CA 1530 3.814 RF00177,RF01959,RF01960 URS000080E24C_562 19696352 0003735 0005840 562 ugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggauca ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<.<..>.>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<...<....>.>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<.<.......>>>.>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((((((((..)))))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....))).....(((((..((....)))))))..)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(...(((((((.(.......))).)))).)...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))...((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(.(..((...(((....)))...))....).).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.....]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Crystal structure of the E. coli 70S ribosome in an intermediate state of ratcheting; 16S rRNA 4v6d CV 17 3.814 URS000080E2A3_32630 19696352 32630 ucgggcucauaacccga <<<<<.......>>>>> (((((.......))))) Crystal structure of the E. coli 70S ribosome in an intermediate state of ratcheting; P-site tRNA ASL fragment 4v6d DA 2841 3.814 RF02540,RF02541 URS000080E25C_562 19696352 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaacaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauggaaguguggacgccagucugcauggcuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<........>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.<...<<<...<<<.<<<<.......>>>>.>>>..>>.>...>.>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<<..<<<.........>>>..>>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<....<<..>>.....>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<.....<<<<<<<......>>>>>>>....>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<<...>>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((...(((((((((.(...(((...(((.((((.......)))).)))..)).)...).)))))).)))...))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.......(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((..((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((.....{{{....)))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((((.(...(((((((......)))))))..).)))).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..(....)..]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.((((((...))))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Crystal structure of the E. coli 70S ribosome in an intermediate state of ratcheting; 23S rRNA 4v6d DB 117 3.814 RF00001 URS000080DF7E_562 19696352 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggc <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>> (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))) Crystal structure of the E. coli 70S ribosome in an intermediate state of ratcheting; 5S rRNA 4v6e AA 1533 3.712 RF00177,RF01959,RF01960 URS000080E246_562 19696352 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggauca .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<.<<..>>.>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<........<<<<<<.<.......>>>.>>>>..........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((((((((..)))))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((.(.......))).)))).....)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))...((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.....]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Crystal structure of the E. coli 70S ribosome in an intermediate state of ratcheting; 16S rRNA 4v6e AV 17 3.712 RF00005 URS000080DF54_32630 19696352 0030533 32630 ggggauugaaaaucccc <<<<<<.....>>>>>> (((((.......))))) Crystal structure of the E. coli 70S ribosome in an intermediate state of ratcheting; P-site tRNA ASL fragment 4v6e AX 17 3.712 RF00005 URS000080DF54_32630 19696352 0030533 32630 ggggauugaaaaucccc <<<<<<.....>>>>>> (((((.......))))) Crystal structure of the E. coli 70S ribosome in an intermediate state of ratcheting; P-site tRNA ASL fragment 4v6e BA 2854 3.712 RF02540,RF02541 URS000080E25C_562 19696352 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauggaaguguggacgccagucugcauggcuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<.>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<.........>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<.....<<<<<<<......>>>>>>>....>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.(...(((...(((.((((...((((((.)))).))...)))).)))..)).)...).)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((((.(...(((((((......)))))))..).)))).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Crystal structure of the E. coli 70S ribosome in an intermediate state of ratcheting; 23S rRNA 4v6e BB 118 3.712 RF00001 URS0000366A67_562 19696352 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))). Crystal structure of the E. coli 70S ribosome in an intermediate state of ratcheting; 5S rRNA 4v6e CA 1530 3.712 RF00177,RF01959,RF01960 URS000080E24C_562 19696352 0003735 0005840 562 ugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggauca ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<<<..>>>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<<....>>>>>>......>>.>.....<<<....>>>....<<<<<<...<....>.>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<.<.......>>>.>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((((((((..)))))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((.(.......))).)))).....)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))...((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(.(..((...(((....)))...))....).).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.....]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Crystal structure of the E. coli 70S ribosome in an intermediate state of ratcheting; 16S rRNA 4v6e CV 17 3.712 RF00005 URS000080DF54_32630 19696352 0030533 32630 ggggauugaaaaucccc <<<<<<.....>>>>>> (((((.......))))) Crystal structure of the E. coli 70S ribosome in an intermediate state of ratcheting; P-site tRNA ASL fragment 4v6e CX 17 3.712 RF00005 URS000080DF54_32630 19696352 0030533 32630 ggggauugaaaaucccc <<<<<<.....>>>>>> (((((.......))))) Crystal structure of the E. coli 70S ribosome in an intermediate state of ratcheting; P-site tRNA ASL fragment 4v6e DA 2841 3.712 RF02540,RF02541 URS000080E25C_562 19696352 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaacaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauggaaguguggacgccagucugcauggcuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<........>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<.......>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<<..<<<.........>>>..>>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<<........<.....<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.......<<<<<..<<....>>...>>>>>.......>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>.>>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<..<<<.<<<<<.<<<<<<<<<<<.<<<<.....<<<<<<<......>>>>>>>....>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>...>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<<...>>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((...(((((((((.(...(((...(((.((((.......)))).)))..)).)...).)))))).)))...))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.......(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((..((...(((...(((....)))...)))...))...(((((........)))))]]((((((((((.((...((((....((((..(((..((((((((((.....{{{....)))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...)).....)))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((((.(...(((((((......)))))))..).)))).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..(....)..]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((....(((...(((((((((((}}}.))))))..)))))...)))..)))))...(((....((((.............))))....))).))))..]....)))))))(.((((((...))))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Crystal structure of the E. coli 70S ribosome in an intermediate state of ratcheting; 23S rRNA 4v6e DB 117 3.712 RF00001 URS000080DF7E_562 19696352 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggc <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>> (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))) Crystal structure of the E. coli 70S ribosome in an intermediate state of ratcheting; 5S rRNA 4v6f AA 2909 3.1 RF02540,RF02541,RF00002 URS000080E2BB_300852 20400952 0003735 0005840 300852 ggucaagaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaacggcccgcacgcgggccgaaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggauguuggcuuagaagcagccaucauuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucuugacc <<<<<<<<......<<<<<<<<<<<.....[[.(((<<<<<<[[<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<..>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...(((....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>.)))..............<<....>>....]].........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....<<<<<<......>>>>>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<.<<........>>..>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..((((...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.........<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<.(((..>>>>..)))>>>>>>.............>>>>..]]>>>>.......<<<<..<<<<<<<...<<.......>>...>>>>>>>...>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))))>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>>> ((((((((......((((((((((.....(((..((((((((((((......((((((.[[..[[[)))...].((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((..)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((((((((..).))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....(((((((....)))))))....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((.(.((.(((......)))..)))..))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((..(((.........)))..))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(((((((...(((......(((((.(((....))))))))...)))..))))).)).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((.(.(((....))).).)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((((..))))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........(((((..(((......((((((((....))))))))...)))............)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...))))).<.)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((.....))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))..>))))).)))...))))...))))))))) Elongation complex of the 70S ribosome with three tRNAs and mRNA.; 23S RIBOSOMAL RNA 4v6f AB 122 3.1 RF00001 URS00005AB4A7_300852 20400952 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga ..<<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> ..(((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).))))))))))) Elongation complex of the 70S ribosome with three tRNAs and mRNA.; 5S RIBOSOMAL RNA 4v6f BA 1516 3.1 RF00177,RF01959,RF01960 URS000080E21A_300852 20400952 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucaccuccuuu .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<.......>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<<....>>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.............. .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((((((((((...))))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((...(((((((....((........)).......)))))))...).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.(.....).))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...((((((((..(((((((....))))))).(.((((....)))).)))))))))).((.(((..(((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))...(.(((((....))))).)......)))).....).).)))...))))))))....)))))))).[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}............. Elongation complex of the 70S ribosome with three tRNAs and mRNA.; 16S ribosomal RNA 4v6f BD 76 3.1 RF00005 URS00005AA258_562 20400952 0030533 0006412 562 gcccggauagcucagucgguagagcaggggauugaanauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((........)))).(((((.......))))).....(((((.......)))))))))))).... Elongation complex of the 70S ribosome with three tRNAs and mRNA.; TRNA-PHE WITH UNMODIFIED NUCLEOTIDES EXCEPT FOR MIA37 4v6f BB 76 3.1 RF00005 URS00005AA258_562 20400952 0030533 0006412 562 gcccggauagcucagucgguagagcaggggauugaanauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((........)))).(((((.......))))).....(((((.......)))))))))))).... Elongation complex of the 70S ribosome with three tRNAs and mRNA.; TRNA-PHE WITH UNMODIFIED NUCLEOTIDES EXCEPT FOR MIA37 4v6f BC 76 3.1 RF00005 URS00005AA258_562 20400952 0030533 0006412 562 gcccggauagcucagucgguagagcaggggauugaanauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).(((((.......))))).....(((((..]....)))))))))))).... Elongation complex of the 70S ribosome with three tRNAs and mRNA.; TRNA-PHE WITH UNMODIFIED NUCLEOTIDES EXCEPT FOR MIA37 4v6f B1 30 3.1 URS0002335939_300852 20400952 ggcaaggagguuuuuuuuuuuuuuuuuuuu .............................. .............................. Elongation complex of the 70S ribosome with three tRNAs and mRNA.; MRNA 4v6f CA 1515 3.1 RF00177,RF01959,RF01960 URS000080DFBF_300852 20400952 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucaccuccuuu ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<<<<<<<<<<...>>>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<<....>>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.............. ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(.(((((((((...))))))))).).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((...(((((((....((........)).......)))))))...).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.(.....).))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((((..(((((((....))))))).(.((((....)))).)))))))))).((.(((..(((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..((.(((((....))))).)...)..)))).....).).)))...))))))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}............. Elongation complex of the 70S ribosome with three tRNAs and mRNA.; 16S ribosomal RNA 4v6f CD 76 3.1 RF00005 URS00005AA258_562 20400952 0030533 0006412 562 gcccggauagcucagucgguagagcaggggauugaanauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((........)))).(((((.......))))).....(((((.......)))))))))))).... Elongation complex of the 70S ribosome with three tRNAs and mRNA.; TRNA-PHE WITH UNMODIFIED NUCLEOTIDES EXCEPT FOR MIA37 4v6f CB 76 3.1 RF00005 URS00005AA258_562 20400952 0030533 0006412 562 gcccggauagcucagucgguagagcaggggauugaanauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((........)))).(((((.......))))).....(((((.......)))))))))))).... Elongation complex of the 70S ribosome with three tRNAs and mRNA.; TRNA-PHE WITH UNMODIFIED NUCLEOTIDES EXCEPT FOR MIA37 4v6f CC 76 3.1 RF00005 URS00005AA258_562 20400952 0030533 0006412 562 gcccggauagcucagucgguagagcaggggauugaanauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).(((((.......))))).....(((((..]....)))))))))))).... Elongation complex of the 70S ribosome with three tRNAs and mRNA.; TRNA-PHE WITH UNMODIFIED NUCLEOTIDES EXCEPT FOR MIA37 4v6f C1 30 3.1 URS0002335939_300852 20400952 ggcaaggagguuuuuuuuuuuuuuuuuuuu .............................. .............................. Elongation complex of the 70S ribosome with three tRNAs and mRNA.; MRNA 4v6f DA 2912 3.1 RF02540,RF02541,RF00002 URS000080E23D_274 20400952 0003735 0005840 274 ggucaagaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaacggcccgcacgcgggccgaaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggauguuggcuuagaagcagccaucauuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucuugacc <<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.....>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....<<<<<<......>>>>>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<.........>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>>> ((((((((......((((((((((.....(((..((((((((((((......((((((.[[..[[[)))...].((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...(((((((((..).))))))))....{.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).))))....(((((((((.[.....)))))))))....}.(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....(((((((....)))))))....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((...((((((......)))).))...))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......(((((.(((..(((.........)))..))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(((((((...(((......(((((.(((....))))))))...)))..))))).)).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((.(.(((....))).).)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((((..))))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))(...)...((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........(((((..(((......((((((((....))))))))...)))............)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.((((.....))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...))))))))) Elongation complex of the 70S ribosome with three tRNAs and mRNA.; 23S RRNA 4v6f DB 122 3.1 RF00001 URS00005AB4A7_300852 20400952 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga ..<<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> ..(((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).))))))))))) Elongation complex of the 70S ribosome with three tRNAs and mRNA.; 5S RIBOSOMAL RNA 4v6g AA 1517 3.5 RF00177,RF01959,RF01960 URS000080DE3B_300852 20400952 0003735 0005840 300852 guuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucaccuccuug ......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<.......>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<<....>>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.............. ......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((((((((((...))))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((...(((((((....((........)).......)))))))...).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.(.....).))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((......((((((((..(((((((....))))))).(.((((....)))).)))))))))..((.(((..(((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))...(.(((((....))))).)......)))).....).).)))...))))))))....)))))))...)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((..........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}............. Initiation complex of 70S ribosome with two tRNAs and mRNA.; 16S RRNA (E.COLI NUMBERING) 4v6g AC 77 3.5 RF00005 URS000057545F_562 20400952 0030533 0006412 562 cgcgggguggagcagcccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(((((.......)))))))))))..... Initiation complex of 70S ribosome with two tRNAs and mRNA.; TRNA FMET (UNMODIFIED BASES) 4v6g AD 77 3.5 RF00005 URS000057545F_562 20400952 0030533 0006412 562 cgcgggguggagcagcccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(((((.......)))))))))))..... Initiation complex of 70S ribosome with two tRNAs and mRNA.; TRNA FMET (UNMODIFIED BASES) 4v6g A1 23 3.5 20400952 32630 caaggagguaaaaaugaaaaaaa ....................... ....................... Initiation complex of 70S ribosome with two tRNAs and mRNA.; MRNA 4v6g BA 2885 3.5 RF02540,RF02541,RF00002 URS000080DF06_300852 20400952 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaacgcgaaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggauguuggcuuagaagcagccaucauuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<..>>>>>>.>>....<<<<<.....<<....>>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....<..>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<.<.<<<<<<......>>>>.>>>..>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<.<<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>>>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><<<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>.>>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<<........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>.>>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<...<<......<<<<<<<<....>>>>>>>>...>>.............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<<..<<.......>>>..>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[[)))...].((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((..)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...(((((((((..).))))))))....{.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).))))....(((((((((.[.....)))))))))....}.(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).............)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((...((((((......)))).))...))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......(((((.(((..(((.........)))..))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(((((((...(((......(((((.(((....))))))))...)))..))))).)).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((((..))))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))(...)...((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........(((((..(((......((((((((....))))))))...)))............)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...))))).{.)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.((((.....))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))..}))))).)))...))))...)))) Initiation complex of 70S ribosome with two tRNAs and mRNA.; 23S ribosomal RNA 4v6g BB 120 3.5 RF00001 URS00005AB4A7_274 20400952 0003735 0005840 274 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcgggg ....<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>> ....(((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).))))))))) Initiation complex of 70S ribosome with two tRNAs and mRNA.; 5S ribosomal RNA 4v6g CA 1515 3.5 RF00177,RF01959,RF01960 URS000080DE3B_300852 20400952 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucaccuccuug ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<<<<<<<<<<...>>>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<............>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<<....>>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.............. ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(.(((((((((...))))))))).).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((...(((((((....((........)).......)))))))...).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.(.....).))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((((..(((((((....))))))).(.((((....)))).)))))))))).((.(((..(((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))...(.(((((....))))).)......)))).....).).)))...))))))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}............. Initiation complex of 70S ribosome with two tRNAs and mRNA.; 16S RRNA (E.COLI NUMBERING) 4v6g CC 77 3.5 RF00005 URS000057545F_562 20400952 0030533 0006412 562 cgcgggguggagcagcccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Initiation complex of 70S ribosome with two tRNAs and mRNA.; TRNA FMET (UNMODIFIED BASES) 4v6g CD 77 3.5 RF00005 URS000057545F_562 20400952 0030533 0006412 562 cgcgggguggagcagcccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Initiation complex of 70S ribosome with two tRNAs and mRNA.; TRNA FMET (UNMODIFIED BASES) 4v6g C1 23 3.5 20400952 32630 caaggagguaaaaaugaaaaaaa ....................... ....................... Initiation complex of 70S ribosome with two tRNAs and mRNA.; MRNA 4v6g DA 2886 3.5 RF02540,RF02541,RF00002 URS000080DF06_300852 20400952 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaacgaaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggauguuggcuuagaagcagccaucauuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.....>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...........>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<.<.<<<<<<......>>>>.>>.>.>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[....>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<<........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>.>>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<<..<<.......>>>..>>>>>>...>>>>.>.......<.<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>..>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<<.....>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[[)))...].((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...((((((((.....))))))))....{.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).))))....(((((((((.[.....)))))))))....}.(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....()....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((...((((((......)))).))...))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((.........(((((.(((..(((.........)))..))).....(...((......)).).))))).....)))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(((((((...(((......(((((.(((....))))))))...)))..))))).)).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((.(.(((....))).).)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((((..))))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))(...)...((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........(((((..(((......((((((((....))))))))...)))............)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((.(..((((.............))))...)))).))))..]....)))))))(.((((.....))))....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))...)))) Initiation complex of 70S ribosome with two tRNAs and mRNA.; 23S ribosomal RNA 4v6g DB 120 3.5 RF00001 URS00005AB4A7_274 20400952 0003735 0005840 274 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> (((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).))))))))))) Initiation complex of 70S ribosome with two tRNAs and mRNA.; 5S ribosomal RNA 4v6g CB 65 3.5 RF00005 URS000057545F_562 20400952 0030533 0006412 562 ggguggagcagcccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccc <<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>> (((..((((......[..)))).(((((.......))))).....(((((..]....)))))))) Initiation complex of 70S ribosome with two tRNAs and mRNA.; TRNA FMET (UNMODIFIED BASES) 4v6i CA 1721 8.8 RF01960,RF01959,RF00177 URS00005F2C2D_4932 20980660,20974910 0003735 0005840 4932 uaucugguugauccugccaguagucauaugcuugucucaaaguuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauagacauggauaacugugguaauucuagagcuaauacauguuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuuaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccgguccgauuuuuucguguacuggauuuccaacgggguccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaguguucaaagcaggcguauugcucgaauauacguuugguucuauuuuguugguuucuaggaccaucguaauggggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuagagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguugaggcaauaacaggucugugaugcccuuaacguucugggcgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<<..<<<<<...<...........<<<.<<<...<...<<.....<............>....>>>.......<<........<<<..<<..<<...........<<<<.....<<.<<<.....>>>.>>......>>>>.<.<<<.........>>>.>....<.<<<<[......((...((..<..<.....>..>.............>.]..>>>.>.....<..<<<<.<<<<.....>>>>>>>>>.........>>>>..>>>.<<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>...<<<<<<<<....>>>>...>>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.......<.<<<...<<<<.....>>>.>>>>>........>.....<<<<<<<<<<<<<....>>>>>>>>>>.>>>....................................<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>.>>>>.........<<<[[.....<.<<...<<<..............<..<.....<..<..<.....>..>...>..>...>.......<...<.<<.<.<...<<..<....>..>>...>.>.>>.>...>.<<.....<..<......>..>.....>>.<...<<<<<<<<.....))...)).>>>>>>>>..>......<<<<<.<<...<<<<..<<<.<<<<<<.<...<<<......>>>......>.>>>>>>.>>>......<<<....>>>..>>>>..>>.>>>.>>....>>>...>>.>....<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<<.....>.>>>>>>>>>>>..>>>..<<.].]>>...>>.....>>>.>>>.<<<......<<<......>>>....>>>..)))).]<<<<<.<<<<<<<...<..<<<<<..<<<.<<<<<<......<..........>..........<<<<<........<<..<<<....<<............>>........>>>..>>...<..<<<..<<.<<<<<<....<<<.<<<<......>>...<<<......>>>...>>.>>>......<<..<<<.<<<<..<<<<..<<<<<......>>>>>....>>>>..>>>>>>>.....<<<<.......>>>>........>>......>>>.>>>.....>>>>>.>......>>>>>..>>.>>>>.>>>.....<<<<<.........<..........<<<....>>>..........>.........>>>>>...........<<<<<<..........>>>>>>..........>>>>>.....<<<<<<<<<.....>>>>>>>>>......>....>>>>>>>>>>.>>.......<<.<..<<...<<....<<<<<<<<.<<<..<.<<......<<<<<<<.<<<<.<<<<....>>>>.>>>>.>>>>>>>......>>.>..>>>.>>>>>>>>...>>...>>...>.>>.........<<<<<<<<<....>>>>>>>>>......... ....[.[..(.(((..].]..(((..(((((.....(...((....(((.(((..((...((......(..........).....))))......(((.......(((..((..((...........((((........(.(.....).).........))))(..(((.........)))..).....(((........[[....[[....(.....).....................)))..........((((..(((.....))).))))..........))))..))).(((....(((..(((((((.........))))))))))......)))...(((..(((....))).....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.....))).))))).)....).......(((((((.(((((....))))).)))).)))....................................(((((........((((.....(......).......)))).)))))..))))).)))..........(.({{...(.(.((...(((..........(...(...........(..(.....)..)..........).....).....(.((.(.(....................).).)).)....(.(........................).)....((((.(.......]]...]]...).))))........((.(((..(...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)..)))..))...)))...)).)....(.((.(....(...((.(.........).))...).).)).)......[...(((.((..((..(((.((((.(.(.(....)..)))))).)))..))...((..}}))...)).....))))).).(((......((.(....).))....)))...))).)((((..((((.((...(..(((.(..(((.((((((.......(........)...........((((...........(.((.....[...........(])..........))).......(.((...((.((((((....(((.(((((....)))....((......))....)).))).....(((.((((.((((..((((...(.((......)).).....))))..))))))).......((.......)).........))).)....))).))).....)).)))........))))..)).)))).))).(...((.((((..............(....((....))....)..............)))).))......(....((((((..........))))))....)..)..).))).......((((((.......))))))........)....)).)))).)).))..(....((.(..(((..((..(..((((((..(((..(.((..(...((.((((.((((.((.(....).)).)))).)))).))...)..)).)..)))..)))))).)..))..)))...).))......)..(((((((((....)))))))))]........ Localization of the small subunit ribosomal proteins into a 6.1 A cryo-EM map of Saccharomyces cerevisiae translating 80S ribosome; 18S rRNA 4v6i CB 75 8.8 RF00005 URS00005AD0B9_4932 20980660,20974910 0030533 0006412 4932 uccgugauaguuuaauggucagaaugggcgcuugucgcgugccagaucgggguucaauuccccgucgcggagcca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>....<<<<<.......>>>>>>>>>>>>.... (((((((..((((........)))).(((.(.......).)))....(((((.......)))))))))))).... Localization of the small subunit ribosomal proteins into a 6.1 A cryo-EM map of Saccharomyces cerevisiae translating 80S ribosome; P-SITE TRNA ASP 4v6i CC 11 8.8 URS000080E0BA_4565 20980660,20974910 4932 aaaagacuuca ........... ........... Localization of the small subunit ribosomal proteins into a 6.1 A cryo-EM map of Saccharomyces cerevisiae translating 80S ribosome; MRNA, RNA (5'-R(P*AP*AP*AP*AP*GP*AP*CP*UP*UP*CP*A)-3') 4v6i DA 3354 8.8 RF02540,RF02543 URS000061F377_4932 20980660,20974910 0003735 0005840 4932 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Localization of the small subunit ribosomal proteins into a 6.1 A cryo-EM map of Saccharomyces cerevisiae translating 80S ribosome; 25S rRNA 4v6i DB 157 8.8 RF00002 URS00001BF64E_4932 20980660,20974910 0003735 0005840 4932 aacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu ........................................<<<<<<........>>>..............<......>...................>>>....<<<...>>><<<<<<<<<....>>>>>>>>>..................... ........................................((((((........))).....(.......((......))..............)...)))....(((...)))((((..(((....)))..))))..................... Localization of the small subunit ribosomal proteins into a 6.1 A cryo-EM map of Saccharomyces cerevisiae translating 80S ribosome; 5.8S rRNA 4v6i DC 118 8.8 RF00001 URS000028DC86_4932 20980660,20974910 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguguuaagcugguagagccugaccgaguaguguaugggugaccauacgcgaaacucaggugcugcaaucu .<<<<<<<.....<<<<<<<......<<.<................>...>>.....>>>>>>>.<<<<<.......<<<<<<<<....>>>>>>>>.....>>>>>..>>>>>>>.. (((((((((....(((((((......((.(((...(....)...)))...)).....))))))).(((((.......((((((((....)))))))).....))))).))))))))). Localization of the small subunit ribosomal proteins into a 6.1 A cryo-EM map of Saccharomyces cerevisiae translating 80S ribosome; 5S rRNA 4v6k AA 120 8.25 RF00001 URS0000049E57_83333 21378755 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<......<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.....<.<<<<<<<<...>>>>>>>>...>...>>....>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......(((((((.....))))))).......))...)))))))))). Structural insights into cognate vs. near-cognate discrimination during decoding.; ribosomal RNA 5S 4v6k AB 2904 8.25 RF02540,RF02541 URS00004B0F34_83333 21378755 0003735 0005840 83333 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<<<<<<<<......<<<<<<<<<<<....{[[.(((<<<<<<<[[<<......<<<<<<.[((.(..>>>.....<<<<<<<..<<<.))).].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.)))..............<<....>>....]].........<<<<.....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<........>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<<.....>>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<<..<<<<.......>>>>..>>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><<.....<<......<<<<<.......>>>>>.<<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<..<<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>>..>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>..<<<<.<<<..<<<<<<<..<<<........<<<<<..<<....>>...>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>...>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>...>>......<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<..<<<<<<<<<<<.<<<<........(..<<<<<.......<...<<<<<<<<....>>>>>>>>>...............).>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>.....>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<.<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>..>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<<...>>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>.. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[.[.))).....(((((((..(((].]..].)))......)))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((..........)))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).(((((((....(((((((((.....(((...(((.((((...(((((((.....))))).))...)))).)))..)).).....)))))).)))....)))))).)...(((((((((........)))))))))....((........))...((((.(((...((([[[...(.(((((......(.....((..(((((..(((.......((((.((((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)....)))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((......(((((.......)))))..(((....((((..((..(((((((...((.....)).))))))....[[(((..((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((((((((((...((((....((((..(((..(((((((((((....{{....))))))((..((((...((((.(((((((.((.....)))))))))...))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).(((.......)))..)))...((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{...((((.....]}.))))...((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((((........[..(((((............(((((((....))))))).................].)))))..)))).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..((.......[.))((((((..........]))))))([((...(((((((...(((((.........))))).....((]...[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]........(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((..(((((..(((((((((......))))))..))).(((((.....))))).....)))))......))..).....(.(((((....))).)).)....))..)))))))))))[...(((((((...((((...((((((.....(....)....))))))..(((((...((((...(((((((((((.}}.))))))..)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.((((((...))))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))).. Structural insights into cognate vs. near-cognate discrimination during decoding.; ribosomal RNA 23S 4v6k BA 1542 8.25 RF00177,RF01959,RF01960 URS00000ABFE9_536056 21378755 0003735 0005840 536056 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggaucaccuccuua ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<<....>>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<....<<<<<<......>>>>>.>....>>.>.....<<<....>>>....<<<<<...<<....>>.>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<....<.<<<<<<.....>>>>>>.>..>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<...<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>......>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.............. ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((((....))))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....(((((...((....)).))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((.(((....)))....))))))).(((((............))))).((((....))))...)))))).).....(.(((....((((....))))..)))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((.(..(((((((.((......((........))..........(((((((..(...(((((((..(((((((....)))))))...((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....))))))).....(((((.....)))))........)))).....).).)))...)).)))))....)))))))...))..))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..).))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..)).)))))..).))...)..)..(((((((((....)))))))))}............. Structural insights into cognate vs. near-cognate discrimination during decoding.; 16S ribosomal RNA 4v6k BB 76 8.25 RF00005 URS00005AA258_536056 21378755 0030533 0006412 536056 gcccgganagcucagncggnagagcaggggauugaanauccccgunnccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((.........)))).....(((((..]....)))))))))))).... Structural insights into cognate vs. near-cognate discrimination during decoding.; A/T-site tRNA Phe 4v6k BD 24 8.25 21378755 562 auuauguuuuuuuuuugauuugcc ........................ ........................ Structural insights into cognate vs. near-cognate discrimination during decoding.; mRNA 4v6k BE 76 8.25 RF00005 URS00005AA258_536056 21378755 0030533 0006412 536056 gcccgganagcucagncggnagagcaggggauugaanauccccgunnccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<...(....>>>>.<<<<<<.....>>>>>>.....<<<<<...)...>>>>>>>>>>>>.... (((((((..((((........)))).((((.........)))).....(((((.......)))))))))))).... Structural insights into cognate vs. near-cognate discrimination during decoding.; A/T-site tRNA Phe 4v6l AA 1542 13.2 RF00177,RF01959,RF01960 URS00000ABFE9_536056 21378755 0003735 0005840 536056 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggaucaccuccuua ........<<<<<.[.((((>>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<<....>>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<....<<<<<<......>>>>>.>....>>.>.....<<<....>>>....<<<<<...<<....>>.>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<.......<<<....>>>......>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>..>>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<...<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<..<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>.........>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>......>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.............. ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((((....))))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....(((((...((....)).))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((.(((....)))....))))))).(((((............))))).((((....))))...)))))).).....(.(((....((((....))))..)))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))..........((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..(((((((.((......((........))..........(((((((..(...(((((((..(((((((....)))))))...((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....))))))).....(((((.....)))))........)))).....).).)))...)).)))))....)))))))...))..))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..)).)))))..).))...)..)..(((((((((....))))))))).............. Structural insights into cognate vs. near-cognate discrimination during decoding.; 16S ribosomal RNA 4v6l AB 76 13.2 RF00005 URS00005AA258_536056 21378755 0030533 0006412 536056 gcccgganagcucagncggnagagcaggggauugaanauccccgunnccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((.........)))).....(((((..]....)))))))))))).... Structural insights into cognate vs. near-cognate discrimination during decoding.; A/T-site tRNA Phe 4v6l AD 24 13.2 21378755 562 auuauguuuuuuuuuugauuugcc ........................ ........................ Structural insights into cognate vs. near-cognate discrimination during decoding.; mRNA 4v6l AE 76 13.2 RF00005 URS00005AA258_536056 21378755 0030533 0006412 536056 gcccgganagcucagncggnagagcaggggauugaanauccccgunnccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>><<<<<.........>>>>.>...<<<<<.......>>>>>>>>>>>>.... (((((((..((((........)))).((((.........)))).....(((((.......)))))))))))).... Structural insights into cognate vs. near-cognate discrimination during decoding.; A/T-site tRNA Phe 4v6l BA 120 13.2 RF00001 URS0000049E57_83333 21378755 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<......<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.....<.<<<<<<<<...>>>>>>>>...>...>>....>>>>>>>>>. ((((((((((.....((((((((....(((.(((...(.....)...)))...)))...)))))).)).((.......(((((((.....))))))).......))...)))))))))). Structural insights into cognate vs. near-cognate discrimination during decoding.; 50S ribosomal RNA 5S 4v6l BB 2904 13.2 RF02540,RF02541 URS00004B0F34_83333 21378755 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacghgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccuu <<<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<.(......>>>.....<<<<<<<..<<<.....).>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<........>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<........>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>...>>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<<.....>>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<..<<..<<<.........>>>..>>.........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>>.......<<......<<<<<.......>>>>>..<<<....<<<<<.<<...<<<<<....<<.....>>..>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<.<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<.<<<<<<<.<<.....>>>>>>>>>...>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>.....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>...<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>..<<<<.<<<..<<<<<<<..<<<........<<<<<..<<....>>...>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>...>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.(((.((......<<<<.((<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<........((.<<<<<...........<<<<<<<<....>>>>>>>>...............)).>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<....((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))........<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..))>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<.<<<..<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>......>>>..>....<<<<<<<....>>>.>>>>....))..)))>>>>>>>>....<<<<<<<...<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<..<<<<<<<<<<<<))).>>>>>>..>>>>>>..>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<<...>>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>.. ((((((((......((((((((((.....(((..(((((((((((((......((((((....[.[.))).....((((((((.(((].]....)))....).)))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).)...(.....((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))....).)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).......((((..(((..........)))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...).)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).(((((((....(((((((((.....(((...(((.((((...(((((((.....))))).))...)))).)))..)).).....)))))).)))....)))))).)...(((((((((........)))))))))....((........))...((((.(((...((([[[...(.(((((......(.....((..(((((..(((.......(((....((..(((.........)))..))......(..(((......))))...)))...)))..))))).))...........]]].)....)))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((......(((((.......)))))..(((....((((..((..(((((((...((.....)).))))))....[[(((..((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((((((((((...((((....((((..(((..(((((((((((..........))))))((..((((...((((.(((((((.((.....)))))))))...))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).(((.......)))..)))...((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((...((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)......((((.....]..))))...((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((((.(......[..(((((............(((((((....))))))).................].)))))).)))).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..((.........))((((((...........))))))([((...(((((((...(((((.........))))).....((]...[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]........(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((..(((((..(((((((((......))))))..))).(((((.....))))).....)))))......))..).....(.(((((....))).)).)....))..)))))))))))[...(((((((...((((...((((((.....(....)....))))))..(((((...((((...(((((((((((....))))))..)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.((((((...))))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))).. Structural insights into cognate vs. near-cognate discrimination during decoding.; 50S ribosomal RNA 23S 4v6m AA 1542 7.1 RF00177,RF01959,RF01960 URS00000ABFE9_562 21499241 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccuua ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<...<<<<<<<<<<....>>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>...<.<<<<<.......<<<<<<<.<.......>>>.>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>........<.<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>>..>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<..<.<<<<<<<........>>>>>>>>...>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>......<.<<<<<<....>>>>>>..>.............. ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((((((((..)))))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(...(((((((.(.......))).)))).)...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))..........((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))...((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)....(((((((....)))))))................ Structure of the ribosome-SecYE complex in the membrane environment; 16S RIBOSOMAL RNA 4v6m AX 11 7.1 21499241 562 ucgccccugaa ........... ........... Structure of the ribosome-SecYE complex in the membrane environment; mRNA 4v6m AV 77 7.1 RF00005 URS000034D020_536056 21499241 0030533 0006412 536056 cggcacguagcgcagccugguagcgcaccgucauggggugucgggggucggagguucaaauccucucgugccgacca <<<<<<<..<<<<.........>>>>.<<<.<<.....>>.>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.........)))).(((.(.......).))).....(((((.......)))))))))))).... Structure of the ribosome-SecYE complex in the membrane environment; FtsQ nascent chain 4v6m B7 120 7.1 RF00001 URS0000049E57_536056 21499241 0003735 0005840 536056 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.....<.<<<<<<<<...>>>>>>>>...>...>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Structure of the ribosome-SecYE complex in the membrane environment; 5S RIBOSOMAL RNA 4v6m B8 2904 7.1 RF02540,RF02541 URS00004B0F34_536056 21499241 0003735 0005840 536056 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccuu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<<.....>>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>.>........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<..<<....>>...>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<..<<<<.<..........<<<<...........<<<<<<<......>>>>>>>..................>>>>.>.>>>>..>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<<...>>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>.. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((...(((((((((.(...(((...(((.((((...(((.(((.....))).).))...)))).)))..)).)...).)))))).)))...))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((..((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((((((((((...((((....((((..(((..(((((((((((....{{{...))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((((.(......[....(((...........((..((((....))))..))................].)))..).)))).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((...))))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))).. Structure of the ribosome-SecYE complex in the membrane environment; 23S RIBOSOMAL RNA 4v6n AA 120 12.1 RF00001 URS0000049E57_562 22467828 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<.<<<<.....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>.>>>>>. (((((.((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......(((((((.....))))))).......))...)))).))))). Structural characterization of mRNA-tRNA translocation intermediates (50S ribosome of class2 of the six classes); 5S ribosomal RNA 4v6n AB 2904 12.1 RF02540,RF02541 URS00004B0F34_562 22467828 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacghgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccuu 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Structural characterization of mRNA-tRNA translocation intermediates (50S ribosome of class2 of the six classes); 23S ribosomal RNA 4v6n BA 1542 12.1 RF00177,RF01959,RF01960 URS00000ABFE9_562 22467828 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggaucaccuccuua ........<<<<..[.((((.>>>>.<<<<..<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<..<<<<<<<<<<....>>>>>>>.>>>>>..>>>>>......<<........<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>.<<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<............>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<........<<<<<(<<.......>>>)>>>>..........>>>>>....>..<<<<<(((...<<<<<.....<..))).>.......>>>>>>>>>>..>>>>.>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>...<<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..>.......<<<<<<..<<<<<<<<<<<<.....>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<.......<<<....>>>.....>>>..))))..]<<<<.<<<<<<<.<<.<<<<<...<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<<..<<<.....>>>>>.....>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>......>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>........<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>.............. ........((((..[.[[[..)))).((((..((((..(((((((((....(((.(((..(((..((.((..(((.(((((((..)))))))..)))))..)))))......(((.......((((((..((...((.((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))).))..)).)))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....(((.((.(.......)))..))).....)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))).))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....(.((((...((...((((.........))))...)))))).)..........((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((.(..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))...((....))..))))).))).((..((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)).))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..).))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((...(((((((((((....((((((.((((..((....)).))))))))))...)))))))))))...))).))))..).))...)..)..(((((..((....))..))))).............. Structural characterization of mRNA-tRNA translocation intermediates (50S ribosome of class2 of the six classes); 16S ribosomal RNA 4v6n BB 76 12.1 RF00005 URS00003A6DC6_562 22467828 0030533 0006412 562 aggggcgnaguucaannggnagagcaccggunuccanaaccgggunuugggagnucgagucucuccgccccugcca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<.........>>>>>>>>>>>.... (((((((..((((........)))).(((((.......))))).....(.(((.......))).)))))))).... Structural characterization of mRNA-tRNA translocation intermediates (50S ribosome of class2 of the six classes); A site tRNA 4v6n BC 47 12.1 22467828 562 aggauaagugcauuauguuuauguggugauuugcccuucuguagcca ............................................... ............................................... Structural characterization of mRNA-tRNA translocation intermediates (50S ribosome of class2 of the six classes); mRNA 4v6n BD 77 12.1 RF00005 URS00001BBAFC_562 22467828 0030533 0006412 562 cgcggggnggagcagccuggnagcucgucgggnucauaacccgaagaucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Structural characterization of mRNA-tRNA translocation intermediates (50S ribosome of class2 of the six classes); P site tRNA 4v6o AA 1542 14.7 RF00177,RF01959,RF01960 URS00000ABFE9_562 22467828 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggaucaccuccuua ........<<<<..[.((((.>>>>.<<<<..<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<..<<<<<<<<<<....>>>>>>>.>>>>>..>>>>>......<<........<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>.<<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<............>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<..........>>.>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<..))).>.......>>>>>>>>>>..>>>>.>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>...<<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..>.......<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<.......<<<....>>>.....>>>..)))).]<<<<<.<<<<<<<.<<..<<<<...<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<<..<<<.....>>>>>.....>>>>>>.....<<<<<.....>>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>...........>>>>.....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<...<<<<<<<<<<<.....<<<<<<.<<<<..<<....>>.>>>>>>>>>>....>>>>>>>>>>>...>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>.............. ........((((...[[[[..)))).((((..((((..(((((((((....(((.(((..(((..((.((..(((.(((((((..)))))))..)))))..)))))......(((.......((((((..((...((.((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))).))..)).)))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......(.((....)).).....))))...(.(((((..((....(((.((.(.......)))..))).....)..).)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))).))))..........((([[...(.((((...(((.(((((((.(((((((((.......((((((.....)))))).....)))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....(.((((...((...((((.........))))...)))))).)..........((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))...((....))..))))).))).((..((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)).))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((...(((((((((((....((((((..(((..((....)).))).))))))...)))))))))))...))).))))..).))...)..)..((((((.((....)).)))))).............. Structural characterization of mRNA-tRNA translocation intermediates (class 4a of the six classes); 16S ribosomal RNA 4v6o AB 76 14.7 RF00005 URS00003A6DC6_562 22467828 0030533 0006412 562 aggggcgnaguucaannggnagagcaccggunuccanaaccgggunuugggagnucgagucucuccgccccugcca <<<<<<<..<<<<........>>>><<<<<<.......>>>>>.>...<<<<.........>>>>>>>>>>>.... (((((((..((((........)))).(((((.......))))).....(.(((.......))).)))))))).... Structural characterization of mRNA-tRNA translocation intermediates (class 4a of the six classes); A site tRNA 4v6o AC 47 14.7 22467828 562 aggauaagugcauuauguuuauguggugauuugcccuucuguagcca ............................................... ............................................... Structural characterization of mRNA-tRNA translocation intermediates (class 4a of the six classes); mRNA 4v6o AD 77 14.7 RF00005 URS00001BBAFC_562 22467828 0030533 0006412 562 cgcggggnggagcagccuggnagcucgucgggnucauaacccgaagaucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Structural characterization of mRNA-tRNA translocation intermediates (class 4a of the six classes); P site tRNA 4v6o BA 120 14.7 RF00001 URS0000049E57_562 22467828 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<.<<<<.....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>.>>>>>. (((((.((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......(((((((.....))))))).......))...)))).))))). Structural characterization of mRNA-tRNA translocation intermediates (class 4a of the six classes); 5S ribosomal RNA 4v6o BB 2904 14.7 RF02540,RF02541 URS00004B0F34_562 22467828 0003735 0005840 562 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Structural characterization of mRNA-tRNA translocation intermediates (class 4a of the six classes); 23S ribosomal RNA 4v6p AA 1542 13.5 RF00177,RF01959,RF01960 URS00000ABFE9_562 22467828 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggaucaccuccuua ........<<<<..[.((((.>>>>.<<<<..<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<..<<<<<<<<<<....>>>>>>>.>>>>>..>>>>>......<<........<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>.<<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<........<<<<<<.<.......>>>.>>>>..........>>>>>....>..<<<<<(((...<<<<<.....<..))).>.......>>>>>>>>>>..>>>>.>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>...<<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..>.......<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..))))..]<<<<.<<<<<<<.<<.<<<<<...<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<<..<<<.....>>>>>.....>>>>>>.....<<<<<.....>>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>......>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>........<<.<.<<<<.<<<..<<<<<<<<<<<.....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>....>>>>>>>>>>>..>>.>>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>.............. ........((((....[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((.(((((((..)))))))..)))))..)))))......(((.......((((((..((...((.((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))).))..)).)))))).(((....((...((((((((.......)))))))).))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......(.((....)).).....))))...(.(((((...(....(((.((.(.......)))..))).....)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....(.((((...((...((((.........))))...)))))).)..........((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......(.((....)).)....)))...]]]..(((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))...((....))..))))).))).((..((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((.(...((..(((.....)))))....).)))))..(..(((((.....))))).....)..)))).....).).)))...)).)).))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((...(((((((((((....((((((.((((..((....)).))))))))))...)))))))))))...))).))))..).))...)..)..((((((.((....)).)))))).............. Structural characterization of mRNA-tRNA translocation intermediates (class 4b of the six classes); 16S ribosomal RNA 4v6p AB 76 13.5 RF00005 URS00003A6DC6_562 22467828 0030533 0006412 562 aggggcgnaguucaannggnagagcaccggunuccanaaccgggunuugggagnucgagucucuccgccccugcca <<<<<<<..<<<<........>>>><<<<<<.......>>>>>.>...<<<<.........>>>>>>>>>>>.... (((((((..((((........)))).(((((.......))))).....(((((.......)))))))))))).... Structural characterization of mRNA-tRNA translocation intermediates (class 4b of the six classes); A site tRNA 4v6p AC 47 13.5 22467828 562 aggauaagugcauuauguuuauguggugauuugcccuucuguagcca ............................................... ............................................... Structural characterization of mRNA-tRNA translocation intermediates (class 4b of the six classes); mRNA 4v6p AD 77 13.5 RF00005 URS00001BBAFC_562 22467828 0030533 0006412 562 cgcggggnggagcagccuggnagcucgucgggnucauaacccgaagaucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(((((.......)))))))))))..... Structural characterization of mRNA-tRNA translocation intermediates (class 4b of the six classes); P site tRNA 4v6p BA 120 13.5 RF00001 URS0000049E57_562 22467828 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<.<<<<.....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>.>>>>>. (((((.((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......(((((((.....))))))).......))...)))).))))). Structural characterization of mRNA-tRNA translocation intermediates (class 4b of the six classes); 5S ribosomal RNA 4v6p BB 2904 13.5 RF02540,RF02541 URS00004B0F34_562 22467828 0003735 0005840 562 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Structural characterization of mRNA-tRNA translocation intermediates (class 4b of the six classes); 23S ribosomal RNA 4v6q AA 1542 11.5 RF00177,RF01959,RF01960 URS00000ABFE9_562 22467828 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggaucaccuccuua ........<<<<..[.((((.>>>>.<<<<..<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<..<<<<<<<<<<....>>>>>>>.>>>>>..>>>>>......<<........<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>.<<<....<<...<<<<<<<.........>>>>>>>.>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<........<<<<.<<<.......>>>.>>>>..........>>>>>....>..<<<<<(((...<<<<<.....<..))).>.......>>>>>>>>>>..>>>>.>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<.....<<<<<<<...<<<......>>>......>>>>>>>............<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>...<<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..>.......<<<<<<..<<<<<<<<<<<<.....>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<...<<<<<<<<.<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<..<<<<<<....<<..<<<.....>>>>>.....>>>>>>.....<<<<<.....>>>>>.........>>>.........>>>...>>>>>>>>>...>>>>>>>...>..>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>......>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<.....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>....>>>>>>>>>>>..>>.>>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>.............. ........((((...[[[[..)))).((((..((((..(((((((((....(((.(((..(((..((.((..(((.(((((((..)))))))..)))))..)))))......(((.......((((((..((...((.((((.(.((.....((((((....))))))......)).).....(((....)))....((((((...(....).)))))).)))).))..)).)))))).(((....((...((((((((.......)))))))).))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....(((.((.(.......)))..))).....)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))).))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....(.((((...((...((((.........))))...)))))).)..........((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((.(..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))...((....))..))))).))).((..((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((.(...((..(((.....)))))....).)))))..(..(((((.....))))).....)..)))).....).).)))...)).)).))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..).))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(.(...(((((((((((....((((((.((((..((....)).))))))))))...)))))))))))...).).))))..).))...)..)..((((((.((....)).)))))).............. Structural characterization of mRNA-tRNA translocation intermediates (class 5 of the six classes); 16S ribosomal RNA 4v6q AB 76 11.5 RF00005 URS00003A6DC6_562 22467828 0030533 0006412 562 aggggcgnaguucaannggnagagcaccggunuccanaaccgggunuugggagnucgagucucuccgccccugcca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((........)))).(((((.......))))).....(.(((.......))).)))))))).... Structural characterization of mRNA-tRNA translocation intermediates (class 5 of the six classes); A site tRNA 4v6q AC 47 11.5 22467828 562 aggauaagugcauuauguuuauguggugauuugcccuucuguagcca ............................................... ............................................... Structural characterization of mRNA-tRNA translocation intermediates (class 5 of the six classes); mRNA 4v6q AD 77 11.5 RF00005 URS00001BBAFC_562 22467828 0030533 0006412 562 cgcggggnggagcagccuggnagcucgucgggnucauaacccgaagaucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(((((.......)))))))))))..... Structural characterization of mRNA-tRNA translocation intermediates (class 5 of the six classes); P site tRNA 4v6q BA 120 11.5 RF00001 URS0000049E57_562 22467828 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<.<<<<.....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>.>>>>>. (((((.((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......(((((((.....))))))).......))...)))).))))). Structural characterization of mRNA-tRNA translocation intermediates (class 5 of the six classes); 5S ribosomal RNA 4v6q BB 2904 11.5 RF02540,RF02541 URS00004B0F34_562 22467828 0003735 0005840 562 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Structural characterization of mRNA-tRNA translocation intermediates (class 5 of the six classes); 23S ribosomal RNA 4v6r AA 1542 11.5 RF00177,RF01959,RF01960 URS00000ABFE9_562 22467828 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggaucaccuccuua ........<<<<....((((.>>>>.<<<<..<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<..<<<<<<<<<<....>>>>>>>.>>>>>..>>>>>......<<........<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>.<<<....<<...<<<<<<<.........>>>>>>>.>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<.<<<.......>>>.>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<..))).>.......>>>>>>>>>>..>>>>.>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>...<<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..>.......<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<.......<<<....>>>.....>>>..))))..<<<<<.<<<<<<<.<<.<<<<<...<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<<..<<<.....>>>>>.....>>>>>>.....<<<<<.....>>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>......>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.............. ........((((...[[[[..)))).((((..((((..(((((((((....(((.(((..(((..((.((..(((.(((((((..)))))))..)))))..)))))......(((.......((((((..((...((.((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))).))..)).)))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......(.((....)).).....))))...(.(((((...(....(((.((.(.......)))..))).....)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))).))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....(.((((...((...((((.........))))...)))))).)..........((((((..(((((.((((((.....)))))).)))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((.(..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))...((....))..))))).))).((..((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((.(...((..(((.....)))))....).)))))..(..(((((.....))))).....)..)))).....).).)))...)).)).))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..).))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((...(((((((((((....((((((.((((..((....)).))))))))))...)))))))))))...))).))))..).))...)..)..((((((.((....)).)))))).............. Structural characterization of mRNA-tRNA translocation intermediates (class 6 of the six classes); 16S ribosomal RNA 4v6r AB 76 11.5 RF00005 URS00003A6DC6_562 22467828 0030533 0006412 562 aggggcgnaguucaannggnagagcaccggunuccanaaccgggunuugggagnucgagucucuccgccccugcca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<.........>>>>>>>>>>>.... (((((((..((((........)))).(((((.......))))).....(((((.......)))))))))))).... Structural characterization of mRNA-tRNA translocation intermediates (class 6 of the six classes); A site tRNA 4v6r AC 47 11.5 22467828 562 aggauaagugcauuauguuuauguggugauuugcccuucuguagcca ............................................... ............................................... Structural characterization of mRNA-tRNA translocation intermediates (class 6 of the six classes); mRNA 4v6r AD 77 11.5 RF00005 URS00001BBAFC_562 22467828 0030533 0006412 562 cgcggggnggagcagccuggnagcucgucgggnucauaacccgaagaucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Structural characterization of mRNA-tRNA translocation intermediates (class 6 of the six classes); P site tRNA 4v6r BA 120 11.5 RF00001 URS0000049E57_562 22467828 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<.<<<<.....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>.>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......(((((((.....))))))).......))...)))))))))). Structural characterization of mRNA-tRNA translocation intermediates (class 6 of the six classes); 5S ribosomal RNA 4v6r BB 2904 11.5 RF02540,RF02541 URS00004B0F34_562 22467828 0003735 0005840 562 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Structural characterization of mRNA-tRNA translocation intermediates (class 6 of the six classes); 23S ribosomal RNA 4v6s AA 120 13.1 RF00001 URS0000049E57_562 22467828 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<.<<<<.....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>.>>>>>. (((((.((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......(((((((.....))))))).......))...)))).))))). Structural characterization of mRNA-tRNA translocation intermediates (class 3 of the six classes); 5S ribosomal RNA 4v6s AB 2904 13.1 RF02540,RF02541 URS00004B0F34_562 22467828 0003735 0005840 562 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Structural characterization of mRNA-tRNA translocation intermediates (class 3 of the six classes); 23S ribosomal RNA 4v6s BA 1542 13.1 RF00177,RF01959,RF01960 URS00000ABFE9_562 22467828 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggaucaccuccuua ........<<<<..[.((((.>>>>.<<<<..<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<..<<<<<<<<<<....>>>>>>>.>>>>>..>>>>>......<<........<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>.<<<....<<...<<<<<<<.........>>>>>>>.>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<............>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<.<<<.......>>>.>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<..))).>.......>>>>>>>>>>..>>>>.>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<.....<<<<<<<...<<<......>>>......>>>>>>>............<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>...<<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..>.......<<<<<<..<<<<<<<<<<<<.....>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<...<<<<<<<<........<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<<..<<<.....>>>>>.....>>>>>>.....<<<<<.....>>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>......>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>......>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<...<<<<<<<<<<<<....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>...>>>>>>>>>>>>...>.>>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>.............. ........((((...[[[[..)))).((((..((((..(((((((((....(((.(((..(((..((.((..(((.(((((((..)))))))..)))))..)))))......(((.......((((((..((...((.((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))).))..)).)))))).(((....((...((((((((.......)))))))).))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....(((.((.(.......)))..))).....)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))).))))..........((([[...(.((((...(((.(((((((.(((((((((.......((((((.....)))))).....)))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....(.((((...((...((((.........))))...)))))).)..........((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((.(..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))...((....))..))))).))).((..((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)).))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..).))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((..((...(((((((((((....((((((.((((..((....)).))))))))))...)))))))))))...))..))))..).))...)..)..(((((..((....))..))))).............. Structural characterization of mRNA-tRNA translocation intermediates (class 3 of the six classes); 16S ribosomal RNA 4v6s BB 47 13.1 22467828 562 aggauaagugcauuauguuuauguggugauuugcccuucuguagcca ............................................... ............................................... Structural characterization of mRNA-tRNA translocation intermediates (class 3 of the six classes); mRNA 4v6s BC 77 13.1 RF00005 URS00001BBAFC_562 22467828 0030533 0006412 562 cgcggggnggagcagccuggnagcucgucgggnucauaacccgaagaucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Structural characterization of mRNA-tRNA translocation intermediates (class 3 of the six classes); P site tRNA 4v6t AA 1538 8.3 RF00177,RF01959,RF01960 URS000080DDC0_562 22622583 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccucc .......<<<<....((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<...<<<<<.<<........>>.>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<<..>>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).........<<<<<<.<<.<<<<<<..<<<<<<<<.<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>.............>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>..>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>...........<..<<.<.<<<<..<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>..>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>........... .......((((....[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((.(....).))))).)))))..)))))......(((......(((((((..((...(((((((...((.....((((((....))))))......)).......(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(..(.((((((((.......)))))))).)...)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]]........(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((.(((....))).)))....(....)...))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...(...(((.....))).)....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....((((((..........))))))....)..)..))))).....(((((((.........)))))))......))...)))))).).........(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...).....(((((((((....)))))))))}.......... Structure of the bacterial ribosome complexed by tmRNA-SmpB and EF-G during translocation and MLD-loading; 16S ribosomal RNA 4v6t AV 334 8.3 RF00023 URS000037602E_562 22622583 0006401 562 ggggcugauucuggauucgacgggauuugcgaaacccaaggugcaugccgaggggcgguuggccucguaaaaagccgcgcuuuagcagcuuaauaaccugcuuagagcccucucucccuagccuccgcucuuaggacggggaucaagagaggucaaacccaaaagagaucgcguggaagcccugccugggguugaagcguuaaaacuuaaucaggcuaguuuguuaguggcguguccguccgcagcuggcaagcgaauguaaagacugacuaagcauguaguaccgaggauguaggaauuucggacgcgggnucaacucccgccagcuccacca <<<<<<..............<<<<<<<<.<.....<<..<<<.<<<<<<<<<<.(((((...>>>>>......)))))<<<<<<.<<<.........>>>..>>>>>>.<<<<<.<<<<..<<<...(((((>>>..>>>>.....>>>>>...........)))))...<<<<...<<<<..((((..>>>>...>>>>............))))...<<<<<<<<..<<<..[[.(((>>>..>>>>>>>>..........))).]]....>>>>>....>>>..>>.....>>>>>>>>>...<<<<<.......>>>>>.>>>>>>.... (((((((.............((..((((.....(.((..(((.((((((((((.[[[[....))))).......]]]](((.((.(((.........)))..)).)))((((((.(((...(((...[[[[.)))...))).....))))))...........]]]]...(((......((...[[[..))......)))............]]]...(((((..((..((...[[.[.[.))..))..))))).........].].]]....)))))....)))..)).)....))))..))...(((((.......)))))))))))).... Structure of the bacterial ribosome complexed by tmRNA-SmpB and EF-G during translocation and MLD-loading; full length transfer messenger RNA (tmRNA) 4v6t AX 77 8.3 RF00005 URS000041AF00_562 22622583 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .(((((...((((......[..)))).(((((.......))))).....(.((...].....)).).)))))..... Structure of the bacterial ribosome complexed by tmRNA-SmpB and EF-G during translocation and MLD-loading; formyl-methionine specific initiator transfer RNA 4v6t BA 2903 8.3 RF02540,RF02541 URS000080E25C_562 22622583 0003735 0005840 562 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<<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<.....<<<.<<<<....<<<<<.......>>>>.>....>>>>.>>>.....>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<....<...........>....>>........<<........>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<............>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>>.<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>.<..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<...<<......<<<<<<<<....>>>>>>>>...>>.............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((....(((((......)))))....)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....((.....(..((.........(((.....)))..........))..)....).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((..((...................))......(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((..........))))))....))))))(((((((...(((......((((((((....))))))))...)))..))))).)).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((..((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..(.(((....))).)...))))))...)))...))))(..).....))))...))......))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((.(......).(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((((.(.........(((((...((.......(((.(((....))).)))....)).............)))))).)))).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Structure of the bacterial ribosome complexed by tmRNA-SmpB and EF-G during translocation and MLD-loading; 23S ribosomal RNA 4v6t BB 119 8.3 RF00001 URS000080E133_562 22622583 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>> ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))) Structure of the bacterial ribosome complexed by tmRNA-SmpB and EF-G during translocation and MLD-loading; 5S ribosomal RNA 4v6u A1 77 6.6 RF00005 URS00001D39A7_186497 23222135 0030533 0006412 186497 ggggcgguagcucagccugggagagcaccggacugaagauccgggugucggggguucaaaucccccccgccccacca <<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.........))))((((((.......))))).)...(((((.......)))))))))))).... Promiscuous behavior of proteins in archaeal ribosomes revealed by cryo-EM: implications for evolution of eukaryotic ribosomes; E-tRNA 4v6u A2 1495 6.6 RF00177,RF01959,RF01960 URS000012A2B3_186497 23222135 0003735 0005840 186497 auuccgguugauccugccggaggccacugcuauggggguccgacuaagccaugcgagucaagggggcgucccuucugggacgccaccggcggacggcucaguaacacgucgguaaccuacccucgggagggggauaaccccgggaaacuggggcuaaucccccauaggccugggguacuggaagguccccaggccgaaagggagccguaaggcccgcccgaggaugcggcggcggccgauuagguaguuggugggguaacggcccaccaagccgaagaucgguacgggccgugagagcgggagcccggagauggacacugagacacggguccaggcccuacggggcgcagcaggcgcgaaaccuccgcaaugcgggaaaccgcgacggggggacccccagugccgugccucuggcacggcuuuuccggaguguaaaaagcuccgggaauaagggcugggcaaggccgguggcagccgccgcgguaauaccggcggcccgagugguggccacuauuauugggccuaaagcggccguagccgggcccguaagucccuggcgaaaucccacggcucaaccguggggcucgcuggggauacugcgggccuugggaccgggagaggccggggguacccccgggguaggggugaaauccuauaaucccggggggaccgccaguggcgaaggcgcccggcuggaacggguccgacggugagcgcggaaggccaggggagcgaaccggauuagauacccggguaguccuggcuguaaaggaugcgggcuaggugucgggcgagcuucgagcucgcccggugccguagggaagccguuaagcccgccgccuggggaguacggccgcaaggcugaaacuuaaaggaauuggcgggggagcacuacaagggguggagcgugcgguuuaauuggauucaacgccgggaaccucaccgggggcgacggcaggaugaaggccaggcugaaggucuugccggacgcgccgagaggaggugcauggccgccgucagcucguaccgugaggcguccacuuaagugugguaacgagcgagacccgcgcccccaguugccagucccucccgcucgggaggaggcacucuggggggacugccggcgauaagccggaggaaggggcgggcgacgguaggucaguaugccccgaaacccccgggcuacacgcgcgcuacaaugggcgggacaaugggacccgaccucgaaaggggaagggaauccccuaaacccgcccucaguucggaucgcgggcugcaacucgcccgcgugaagcuggaaucccuaguacccgcgugucaucaucgcgcggcgaauacgucccugcuccuugcacacaccgcccgucacuccacccgagcggaguccgggugaggccugaucuccuucgggaggucaggucgagcccgggcuccgugaggggggagaagucguaacaagguaaccguaggggaaccuacggcucgaucaccuccu ...<<<<<.[.((((>>>>>.<<<<<<<<<....<<<<.<<......<<<.<<<..<<<..<<.<<<<<<<<....>>>>>>>>.>>>>>......<<........<<<<<.<...<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<<<<<.<<<....>>>>>>>>>>>>....<<..<<<....>>>>>.>>>>>>>..>.>.>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>..>>>>...<<<<<<<<...>>>>>>>>...<<<<<<<<.......>>>>>>>>.....<<<<<((.....<<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((......<<....<<<.<<<<<<<.<<<<<<<<<.....<<<<<<<<.....>>>>>>>>....>>>>>>>..>>>>>>>>>...<<<<<<.....<<<<<<<<<..<<<<<<<<<..<<<......>>>.....>>>>>>>>>..>>.......<<....>>.>>>>>>>....>>>.>>>...>>>....>>....<<<<<<<...<<...<<<<.........>>>>...>>>>>>>>>.........<<<<<<..<<<<<<<<<<<<<<.....>>>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<...<<<<........<<<.<<<.......>>>.>>>......>>>>...<<.<<<..<<<<<<<<<....<<<<<<.<<....>>...<<<<......>>>>..>>>>>>....<<<<<.<<<<<<<...<...<.<<<<<<<..>>>>>>>>.>....>>>>>>>.....<<<<<.....>>>>>........>>>>>....>>>.>>>...>>>>>>>>....>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>.....<<<<<<.........>>>>>>.......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<..<<<<<<<<<<<<<..>>>>>>>>>>>>>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<.<<<<<<<....>>>>>>>.>............ ...((((..[.[[[..)))).((((((.((....((((.(((.....(((.(((..(((..(..((((((((....))))))))..))))......(((.......(((((.(...(...(((((((.(((((....((((((....)))))).....)))))...(((((((((.((......)))))))))))....((..(((....))))).)))))))..).).))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).))..))))...((((.(((...))).))))....((((((.........))))))......((((.[[.....(((((.....((..]])).......))))).))))..)).))))))..........((([[...(..((....(((.(((((((.((((((..(......(((((((.....))))))).....)..))))..)))))))))..(((((((.....((((((.((..((((((((...((........))......))))))))..)).......((....))..))))))....))).)))..))))....)).....((((((...((...((((.........))))...))))))))......{...((((((..(((.((((((((((.....)))))))))).)))...((..]])).....))))))))))..((......((((....))))....))....]]].](((((.(((((((..((.((((((..((((((((((......((........))..........(((((((...((((.(......(((.((.(.....).)).)))...)..))))...((.(((...(.(((.((....((((((.((....))...((((......))))..))))))....(((((.((((((....(.....((((((....)))))).)......)))))).....(((((.....)))))........)))))....))..)))....).)))))....)))))))...)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..)))))).....(((((.(.......).))))).......))...)))))))))).))..(.(..((.(.((((.(((...((((((((((((..(.(((((.((((....)))).))))).)..))))))))))))...))).))))..).))...)..)..(.(((((((....))))))).)}........... Promiscuous behavior of proteins in archaeal ribosomes revealed by cryo-EM: implications for evolution of eukaryotic ribosomes; 16S rRNA 4v6u A0 76 6.6 RF00005 URS00005EC276_186497 23222135 0030533 0006412 186497 gccgccguagcuuagcugguggagcgccggacuguuaauccggcgguccccgguucgaauccgggcggcggcgcca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).(((((.......))))).....((.((..]....)).))))))))).... Promiscuous behavior of proteins in archaeal ribosomes revealed by cryo-EM: implications for evolution of eukaryotic ribosomes; P-tRNA 4v6u B1 3049 6.6 RF02540,RF00002 URS00005F73E8_186497 23222135 0003735 0005840 186497 gggcuaggacgcuaagccgcccgguggauggcucggcucggggcgccgacgaagggcguggcaagcugcgauaagccccggcgaggcgcaggcagccgucgaaccggggauucccgaaugggaccucccgcggcuuaugccgcacuccgggguuuauccccggagggggaacgcggggaauugaaacaucuuaguacccgcaggaaaagaaagcaaaagcgaugccgugaguaggggcgaccgaaaacggcagagggcaaacugaaccccgggccgacgagguucgggggaugugggguuguagggcccccguaugagacccucgcgggugaagccgaaguccgcuggaacgcggcgccggagagggugauagccccguaggcguaagcccgcagggucucgggggacccugaguaccgucgguuggauauccggcgggaagcugggaggcaucggcucccaacccuaaauacgucccgagaccgauagcgaacuaguaccgugagggaaagcugaaaagcaccccgggaggggggugaaaagagccugaaaccgggcggcgauaggagggugcggcccgaaaggaaugagccuccccgaaggaaaccgcggcgacgcgggaguacgaggggaggggaccgggguugcaccguccgucuugaaacacggggcagggaguucgcggccguggcgagguuaaggggguuaagccccguagccgcagggaaaccgacaugcccgcagccgggcuuaugcccggugaggggcggggugcgaaagcgcccggagucacggccgcgagacccgaaaccggucgaucuagcccggggcagggugaagucccucaaccgagggauggaggcccgcuaggggugcugaugugcaguucgcucccgugaccccgggcuaggggugaaaggccaaucgaggccggagauagcugguucccgccgaaucaucccgcaggauggccuccccggagguaggcggugggguagagcacugauuggaggugcagggggcgaaagcccccggccuccugucaaacuccgaacccaccgccgccguagauggggggaguaggguggcgguguaagccguccaccgagaggggaacaacccagaccgggguuaaggccccaaagugccggcuaaguguuacuccaaagggugucccgggccuuagacagcggggagguaggcuuagaagcagccauccuuuaaagagugcguaacagcucacccgucgagguccggggccccgaaaauggacggggcucaagccggccgccgagaccccggcgcacggaccgauugguccgugaucggguaggcgggcgugccgguggcguagaagccgggccguaagguccgguggagccgccgguaucgcggauccugccgggaguagcagcguagucgggugagaaucccgaccgccggaggggccaggguuccacggcaauggucgucagccguggguuagucgguccuaaccccgcccguaacucggcgcgggggaaagggaaacggguuuauauucccguaccgcggggguaggugcggcaacgcaagcccggagggugacgccucgggguaggcggaccggccgaugaggccggcuaagcguauaagcccggggagugccguaauggcgagaaccgggugaaagcgcgaauggcccccccguuagggggguuccgccgaucccuggggcccgugaaaagcccuccgggaauuccgaucccccgcgaccguaccgagaaccgacacaggugccccugggugagaagccuaaggcgugucgggggaaacccggccgagggaacucggcaaacuggccccguaacuucgggagaaggggugccugcgggugcguaacccgcaggucgcagugacuaggggggcccgacuguuuaauaaaaacacaggucccagcuagcccgaaaggguuuguacuggggccgacgccugcccagugccgguaugugaagcccggguacaaccgggugaagcaccgguaaacggcggggguaacuauaacccucuuaagguagcgaaauuccuugucgguuaaaugccgaccugcaugaauggcguaacgagguccccgcuguccccggccggggcccggcgaaaccucugccuggcgcgcaugccagggacccccggugggaagcgaagaccccauggagcuuuacugcagccugccguugccacacggcggggggugcgcagcguaggcgggaggcgucgaagcccggccuccgggucggguggagccguccaugagacaccgcccacuccccgcuguguggcuaacccccgaaaggggggacagcgguaggugggcaguuuggcuggggcggcacgccuccgaaaagguaucggaggcgcccuaaggucggcucaggcgggucaggaauccgccguagagugcaagggcaaaagccggccugacuggacccguaacagaggcggguccagccccgaaaggguggccuagcgaaccccugugccuccccggugggggccagggaugacagaaaagcuacccuggggauaacagagucgucucgggcgagagcccauaucgaccccgaggcuugcuaccucgcugucggcucuucccauccuggcccugcagcaggggccaaggguggggguguucacccauuaaaggggaacgugagcuggguuuagaccgucgugagacaggucggaugcuaucuaccggggguguuggccgccugaggggaaggugccccuaguacgagaggaacagggugccgcggccucuggucuaccgguuguccucccgggcaucgccgggcagcuacgccgcagccgauaaggccugaaagcaucuaaggccgaagcggcccccgaaaauaggcggccguucccuggcgcuugggccugggcgaccggcccauugccagggacgagggcucggguagaagacccgguugauagggcggggauguaagcgggaagggucaaccgacccgcuuaguccgccgccccuaaucgcccgagguccugcccc 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(((..(((.......(((((((((.....(((..((((((((...((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....((.....)).((((......)))).((((((((....).))))))).))...((((((.....(...[..)......))))).)...(.....((....))....(((......((.]...)).....)))....((((...(...((((((..((.....))..)))))....).)..........(((.((......(((((.((((((...(((...(.((((......)))))[[......(((.....]])))...)))....)))))))))))..)))))......)....(((.(((........))).)))......(((((.[[[[[[)))))..)))....)....)))))).))...............((....))....))......(..((((.....))))..........)).....)))))))))........((((((((((....((......(((((((...(....(((((....))))).....)..)))))))...)).)))))))))).[((((........))))((((((....(((((((((((((..(((....(((.......)))...)))...((....)).....((((....((((((....))))))....)))).((((((....))))))...)))))))))))))..((.(...((((.(.....(((((((((..((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))....))))))))).(.(((.....)))...)..).))))......).))..((((((....(((((....)))))..((((((...(((.(((((((((...(((...(........(.....(.((.......)).)...).......)..)).)...))))))))))))......))))))....((..((((((....))))))..))....(((......)))...(((((((...((([[[...(.((((((.....((.........(((.(((((((.(..............(((..(((.........)))..))).....(..............)..........).))))))))))..........]]]))....))))))))))...)))))))((((((((((....))))))))..))....))))))(.((((((((((......((((((((....))))))))...))))))))))..).....))))))((.....((......((((((.......))))))((((....((((..((..(((((((...((.....)).)))))).....[(((.((...((((((.((.....))..))))))....))...(((((........)))))].((((((((....((((....)))...(...((((((...(((((.(((.....((.((((((.....))))))(...((((.....(((((.....(((.....))).....))))).....))))....)(.((((((....)))))).).).)....))).)))))(...)....))))))...))........)))))))).))).)))......(......)..))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((.....))))))))))(...).......((((.((((.].((.........))...((.((((.....(((....))).......)))).)).}.(((.(((..(((((((..(((....(((((......)))))....))))))))..)))))(((((.........)))))........(...........(((((.......))))).....)....)))....)).)).)))).)..))).)))))))).))))))....))....(((((.....]..)))))..((((((((.(((.((......((((.((((((..(((((.((((((((..((((((((((((.(((((.........(((((..(((........((.(.((...))).)).....)))............)))))))))).))))))))))))...(((((....))))).....))))))))..)))))..(((......[)).)((((((..........])))))).[((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))..........))))..)))))).......(.((.(.((((((...((.......))...))))))...)))..).......(((((.((.(((..(((((((((......))))))..)))..(((.......)))......))).)..)...))).))....(((((((....))).))))....))..)))))))))))....(((((((...((((..(((.(((......(....).....))).)))(((((...((((...((((((((((....)))))..))))).[.)))).)))))..(((....((((.............))))....))).)))).......)))))))...((.((((...((((((.((....))))))))..)))))).....((((.((((.......)))).....(((.((((((((....(((((..((.....))..)))))...))))]))))..)))...)))).....)))..))) Promiscuous behavior of proteins in archaeal ribosomes revealed by cryo-EM: implications for evolution of eukaryotic ribosomes; 23S rRNA 4v6u B3 126 6.6 RF00001 URS000000EE76_186497 23222135 0003735 0005840 186497 cggcggccauagcgggggggccacacccggucucauuucgaacccggaaguuaagccccccagcgaucccgguuguacugcccuccgagagggggcgggaagccggggacgccgccggccacuauc .<<<<<<....<<<<<<<<.....<<<<<<.............>>>>..>>....>>>>>>.>>..<<<<<<<....<<<<<<.<<....>>>>>>>>...>>>>>>>..>>>>>>.......... .((((((....((((((((.....((((((...(.....)...))))..))....)))))).))..(((((((....((((((.((....))))))))...)))))))..)))))).......... Promiscuous behavior of proteins in archaeal ribosomes revealed by cryo-EM: implications for evolution of eukaryotic ribosomes; 5S rRNA 4v6v AA 1542 9.8 RF00177,RF01959,RF01960 URS00000ABFE9_562 23403578 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggaucaccuccuua ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<..<<<..<<<..<<.<<..<<<<<<<<<<<..>>>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<.<.<<<<<<<.<.<<.....<<<<<<....>>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>.>>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>.>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>...<.<<<<<......<.<<<<<<..........>>.>>>>.>........>>>>>....>..<<<<<(((...<<<<<........))).........>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<...<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>......>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.............. ........((((..[.[[[..)))).((((..((((..(((((((((....(((.(((..(((..((.((..(((((((((((..)))))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(..(.((((((.(.......))).)))).)...)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))).))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))..........((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))...((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((..((....))..))))).............. Tetracycline resistance protein Tet(O) bound to the ribosome; 16S ribosomal RNA 4v6v A2 47 9.8 23403578 562 aggauaagugcauuauguuuauguggugauuugcccuucuguagcca ............................................... ............(...).............................. Tetracycline resistance protein Tet(O) bound to the ribosome; mRNA 4v6v A3 77 9.8 RF00005 URS00001BBAFC_562 23403578 0030533 0006412 562 cgcggggnggagcagccuggnagcucgucgggnucauaacccgaagaucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Tetracycline resistance protein Tet(O) bound to the ribosome; P-tRNA 4v6v BA 2904 9.8 RF02540,RF02541 URS00004B0F34_562 23403578 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccuu <<<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[.<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..))).......].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<............>.<<<<<<...<<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>>.<<.<...<<<<<<.....<<<<<<.<<..<<<<...<<<<<<......>>>>>>...>.>>>...<<<.<<<<<........>>>>>>>>....>>.>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<...<<.....>>....>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<.<<<<<<<......>>>>>>>.>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<<..<<<<.......>>>>..>>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>..<<<<.<<<..<<<<<<<..<<.<.......<<<<<..<<....>>...>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>...>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.((......<<<<.((<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<.<<<..<.<......<<<<<<<<....>>>>>>>>...>.>............>>>>...>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>.(<<...<<<<<<<...<<<<<<.......>>>>>>.....<<).....>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>..........<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..))>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.........<<<.<<<<<...<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>......>>>>..>...>>>.......<<<<<<<....>>>.>>>>....))..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<<...>>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>.. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...((.]]]..]..)).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).)...(.....((....))...(((((.....((.]...))....)))))...((((.((((......(.(((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))))))))).)...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))....).)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((.(((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).)).)))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).(((((((.(..(((((((((.....(((...(((.((((...(.((..(.....)..))..)...)))).)))..)).).....)))))).)))...))))))).)...((.((((((........)))))).))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((.((((((....)))))).))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((......(((((.......))))).((((....((((..((..(((((((...((.....)).))))))....[[(((..((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((((((((((...((((....((((..(((..(((((((((((....{{{...))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).(((.......)))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(..........(((((..((....))...)))))..........))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.(.((((..(((((.(((.(((((.(((((((((((.((((...........(..((...(.......((((((((....))))))))....).............)).)...)))).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...((((.(........))))).....((][...[))....)))))))...((((..((((..{.))))..)))).(((....))).))]...].....(((((((.((..]]]]..))))))))).....)}......))))...)))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.(((((...(((((((((......))))))..))).(((((.....)))))......))))..)...))..).....(.(((((....))).)).)....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((.(.....}.......).))....))).))))..]....)))))))(.((((((...))))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))).. Tetracycline resistance protein Tet(O) bound to the ribosome; 23S ribosomal RNA 4v6v Ba 120 9.8 RF00001 URS0000049E57_562 23403578 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......(((((((.....))))))).......))...)))))))))). Tetracycline resistance protein Tet(O) bound to the ribosome; 5S ribosomal RNA 4v6w B2 1957 6.0 RF01960,RF01959,RF00177 URS000030AF9A_7227 23636399 0003735 0005840 7227 auucugguugauccugccaguaguuauaugcuugucucaaagauuaagccaugcaugucuaaguacacacgaauuaaaagugaaaccgcaaaaggcucauuauaucaguuaugguuccuuagaucguuaacaguuacuuggauaacugugguaauucuagagcuaauacaugcaauuaaaacaugaaccuuaugggacgugugcuuuuauuaggcuaaaaccaagcgaucgcaagaucguuauauugguugaacucuagauaacaugcagaucguauggucuuguaccgacgacagaucuuucaaaugucugcccuaucaacuuuugaugguaguaucuaggacuaccaugguugcaacggguaacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacaucuaaggaaggcagcaggcgcguaaauuacccacucccagcucggggagguagugacgaaaaauaacaauacaggacucauauccgaggcccuguaauuggaaugaguacacuuuaaauccuuuaacaaggaccaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcgguuaaaacguucguaguugaacuugugcuucauacggguaguauacuauaccuuuauguauguaagcguauuaccgguggaguucuuauaugugaucauauguuccuccuauuuaaaaaccugcauuagugcucuuaaacgaguguuauugugggccgguacuauuacuuugaacaaauuagagugcuuaaagcaggcuucaaaugccugaauauucugugcaugggauaaugaaauaagaccucuguucugcuuucauugguuuucagaucaagagguaaugauuaauagaagcaguuugggggcauuaguauuacgacgcgagaggugaaauucuuggaccgucguaagacuaacuuaagcgaaagcauuugccaaagauguuuucauuaaucaagaacgaaaguuagagguucgaaggcgaucagauaccgcccuaguucuaaccauaaacgaugccagcuagcaauuggguguagcuacuuuuauggcucucucagucgcuuccgggaaaccaaagcuuuuugggcuccgggggaaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaacuuaccaggucgaacauaaguguguaagacagauugauagcucuuucucgaaucuaugggugguggugcauggccguucuuaguucguggagugauuugucugguuaauuccgauaacgaacgagacucaaauauauuaaauagauaucuucaggauuauggugcugaagcuuauguagccuucauucauguuggcaguaaaaugcuuauuguguuugaauguguuuauguaaguggagccguaccuguugguuugucccauuauaaggacacuagcuucuuaaauggacaaauugcgucuagcaauaaugagauugagcaauaacaggucugugaugcccuuagauguccugggcugcacgcgcgcuacaaugaaaguaucaacguguauuuccuagaccgagagguccggguaaaccgcugaaccacuuucaugcuugggauugugaacugaaacuguucacgaugaacuuggaauucccaguaagugugagucauuaacucgcauugauuacgucccugcccuuuguacacaccgcccgucgcuacuaccgauugaauuauuuagugaggucuccggacgugaucacugugacgccuugcguguuacgguuguuucgcaaaaguugaccgaacuugauuauuuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<...[[[[>>>>>[[[[.((((((................{{{.{{{..<<....<<....<<.........>>...>>.>>................{{{.{{{..{{....[[[[..............<<.....<<.<<<.....>>>.>>......>>..........<<<<<............>>>>>[[..(((((.....<<<<<<<<.<<<<<....>>>>>...................)))))...]]...<<<<.<<<<.....>>>>>>>>...]]]]...}}}}}.}}}.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>....<<.<<<..........>>>.>>.<.<<....>>.>...}}}}}}.........<<<....<<<.....>>>..>>>...............<<<<<<<<<.<<<......>>>..>>>>>>.>>>...<..<<<.<...........>>.>>>........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........{{{{{.....[[[[...[[[.[[.....<<<<.<<<<.<<<<<<<>>>>..>>.>....>>>>..>>>>....<<<<<<.<<<<.....<<<<<<<<>>>>>>>>..>>>>..........<<<<<<.<<<<<<<<......>>>>>>>>.>>>>>>>>>>>>..<<<<<<.<<.......<<...<.......>..<<<.......>>>....>>.......>>.>>..>>>>........((((((.(..(.......>>>>>>>>...)..))))))).....]]....<<<<..<<<<...<<<<..<<<.<<<<<<<<.<.<<<......>>>.....>>>>>>>>>.>>>.......<<....>>...>>>>..>>>>.>.>>>...]]]...]]]]....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<.<..<<<<......>>>>.>.>>>>>..>>>...<<..}}>>...>>......>>>.}}}.<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<...<<<<........<<<.<<<........>>>.>>>......>>>>...<<.<<<..<<.<<<<<<....<<<<<<<<<....>>>...<<<......>>>...>>>>>>....<<<<<.<<..<<<<..<<..<<<..<<<<..<<<<<<......<<<<<<<<<<<.<<<<..<<<<<.<<<<......>>>>.>>.>>>..>>>>...>.>>>>>>>>>>...>>>>>>>>>>..>>>..<<<<........>>>>.....>>..>>>>.>>.....<<<<<.....>>>>>.......>>>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<........<.....<<<.<<<<....>>>>.>>>....>.........>>>>>>................<..........>...............>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<.<<<.<<<..<<<<..<.....<<<.<<<<<<<<<<.<....>>>>>>>>>.>>..>>>.....>..>>>>..>>>.>>>.>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[[.))))((((.((((((...(.((..((.....(((.(((..((....((....((.........))...)){))......(((.......(((.(((..((....((((..............((.....((.(((.....))).))......))..........(((.(..((....))..).)))(((.((((......[[[[[[[[.(((((....)))))......((........).).)))).).)).(.((((.((((.....)))))))))..))))...))))).))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)...)).).....(((((((((.(((......))).).))))).)))....(.(((.(...........)).))......)..((((([[......((((.....((..]])).......)))).)))))..)))))))))).........((({{...(.((((...(((.((.....((((..(((..(((((())))..))......)))...))))....(..(((.((((.....(((((((())))))))..))))..........((..((.((...(((......)))...)).))..)))))..)...(((((.((.......((..((.......)).(((.......)))....)).......)).))..)))........(((((((.(..........]]]]]]]]......)))))))..)..))...((((((..(((...((((..(((.((((((((.(.((........)).....))))))))).))).......((....))...))))..))).)).)))..))))...))))....((((((....(...((((.........))))...).))))))......<...(((.((.(((.((((((.(..(((........))).).)))))).)))...((..}}))...))......))))))).(((......((((....))))....)))..]]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(...((((......(.(((.(((........))).)))...)..))))...((.(((...(.((((((....(((((((((....)))..(.((......)))...))))))....(((((..(..((((..((..(.(..((((..((.((.......(((((..((((.((((..((..(..(((......)))..)...))..))))...).)))..)))))....)).))))))..).)..((((........)))).....))..)))).)...(..(((((.....))))).....).)))))....))).))).....).))))).....).)))))...)).)))).))).(...((((((........(.....(((.((((....)))).)))....).........))))))......(....(....(..........)....)....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(.((((.(((.(((..((((..(....(.((.(((.((.(((.......))).)).).))..)).)....)..))))..))).))).)))))..)).))))...).))...)..)..(((((((((....)))))))))>........ Structure of the D. melanogaster 80S ribosome; 18S ribosomal RNA 4v6w BC 75 6.0 RF00005 URS000080DDE9_7227 23636399 0030533 0006412 7227 agcagaguggcgcaguggaagcgugcugggcccauaacucagagguccgaggaucgaaaccuugcucugcuacca <<<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((....[..)))).(((.(.......).))).....(.(((..]....))).)))))))).... Structure of the D. melanogaster 80S ribosome; E-tRNA 4v6w A5 3806 6.0 RF02540,RF02543 URS000080DF1B_7227 23636399 0003735 0005840 7227 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..............................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..[[[..........<<<<<<<<<<.....>>>>>>.>>>>.............<.<.<<......<<<<<<<......<<<<<<<.<......<<<<.......>>>>.......((......<<<.....))>>>....>.>>>>>>>...>>>>>>>....>>.>.>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>...................................<<<<<.<..<<<<<........<<<<<<<<<.....<<<<<...<<<<<<<<<<.....>>>>>>>>>>...>>>>>......>>>>>>>>>......<<<<<<..<<<<<<<<<<<.<<.<<<....<<.<<<...<<<.....<.<<<.<....<<<<...>>>>...>.>>>.>........>>>..>>>.>>....>>>.>>.>.>>>>>>>>>>..........<<<<<<<<..<<<<<<....>>>>>><<<<<<<<<<<<<..<<<...>>>..>>>>>.>>>>>>>>.>>>>>.>>>......>>>>>>........>>>>>....>.>>>>>..<<<<........>>>><<<<<<.....<<.<<<<<<<<<..<<<...<<<.......>>>...>>>...<......>.........<<<<<<<.<<<..<<<<<<<<..>>>>>>>>..>>>..>>>>>>><<<<<<<<....<<<<<<.<<<<<<<..<<<....>>>.>.>>>>>>...>>>>>>>>>>>>.>>....>>>>>>>>>.>>...<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<..<.................<<.<.<<<<<<....<<<....<<...<.<<<....<<<<<<.....>>>>>>..>>>.>...>>..>>.>....>>>>>>...<.<.<.<<<..<......>>>>.>.>.>.....>.>>.>..>>>>...>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<(((.......<<<<<.......<.......<..<<<.<<<<<<<<<........<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>....>>>>>>>>>>>>>.........))).>....>>>>>..>>....>>>>>>>.<<<<<<<<....<<<<<<<<<<<<..>>>>>>>>>>>>.....>>>>>>>>.....>>>>>><.<<<<<<<..<<......<<<<..<<<....>>>.>>>>...>>.>>>>>>>..>.....>>>>>><<......<<......<<.<<........>>.>>.<<<<.....<<<<<.<<...<<<<<....<<.....>>..>>>>>....((<<<<<<...<<<<<..<<....>>.............<.......>....>>>>>....>>...<<<<<........>>>>>))<<<<<<<<......<<.<....>>>....<..<.....>.>....<<<....>>>.....<<<<<<<<....<<<..<<<<<<<.<.<<.<<<<..{{{..>>>>.><...<<<<<...<<<<<<<<....<<<.....>>>....>>>>>>>>...>>>>>.....><<<<<<<.....>>>>>>>>.>..>>>.>>>>..>>>..........>>>>>>>>................>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<.<<<<<<<<<<..<<<<<<<<.....<<..<....<<<<<>>>>>....>.>>.....<<.<<<<..<<<>>>..>>>>.>>.>>>>>>>>.......>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<....>>>>......>>>>>>>...<<..<<<..<<<<<<.....<<.....<<<<....>>>>.....>>..>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.........{{{..{{[[[[..<<<<<.<<<<<<<<<.<<<<<<<<<<<<<<<<<..........<<<<....<<<<<<<<<....>>>>>>>>>..............>>>>.>>>>>>>.>>>>>>>>>>...<<<<<.....<<<<...<<<<<<<...<<<<<..<<<<<<.<<<<<<<.....>>>>>>>>>>>>>.>>>>>...>>>>>>>...............<<<<...<<<<..<<..............<<<<<<.<<<<<...<<.<<<<<<....>>>>>>.>>...>>>>>>>>>>>..........>.>.>>>>..>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<.<<<<...<<<.<<.......>>.>>>.....<<...(((>>....>>>>.>>...<<<<.<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}.}}}.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.<.....>.>>>.....>>>>>.>...>>>.>>....<<<<<<<....>>>.>>>>........}}}.]]]]]........<<<<<<<<..<<<<.<.<<<<<<................>>>>>>.><<<<<...<<<<...<<<<<<<<<.}}}..>>>>..>>>>>...>>>>.>>>>>.<<<<....<<<<...........>>>>....>>>>.>>>>....>>>>>>>>.......<<<...<<<.<<<<<<.....................<<<<<<<<......>>>>>>>>...........................<<<<<<.<<....<<<<<<.<<........>>.>>>>>>.......>>>>>>>>...................>>>>>>...>>>>>>.<<<<<.....................<<<<<<<<<.<<<....<<<<....<<<<........>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ..............................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((........(((((((((.........)))).))))....)........(.(..(......(((((((......(((((((.(....({((((.......)))))......[[(...).(((....}]])))....).)))))))...)))))))....)..).)...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............)......................(((((.(..(((((........(((((((((.....((.((...(..(((((((.....)))))))..)...)).))......)))))))))......((((((.((((((((((((.((.((((.(.((.(.(...(((....((.(((..(...((((...))))..)..))).).)......)))..).).)).).)))).)).).))))))))))..........((((((((..(((((......)))))((((((..((.((..(((...)))..)).))...)))))).))))).)))....)).)))))........)))))....).))))).[((((........))))((((((.....((.(((((((((..(((....((.......))....)))...(......).........((((((..(((..(((((((....)))))))..)))...))))))((((((((.....(((((.(.((((...(((....)))...)))).)...))))).)))))).))....))))))))).))...((.(...((((((.....(((((((((..(((....(((((((....)))))))....[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.......(.................((...(((((.....(((....(((..(.(((...(((((((.....))))))).))).)..)))..)).).....)))))...(.(.(.(((..........))).).).).......)).).........))..((((.((.((.....)).)).))))....(((......)))...(((((((...(([[[...(.(.(((((.......(..........(((.((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....)))))))))....)))))))(.(((((((....(((((((((.((..)).))))))))).....))))))).)....))))))(.((((((((.((......((((..(((....))).))))...))))))))))..).....))))))((......((......((.(..........).)).((((.....((((..((...(((((....((.....))..)))))....[[(((.((...(((.(..((....))......)....(.(.(....)).)....)))....))...(((((........)))))]]((((((((......((.......))....((........))...((((....)))......(((.(((....(((..(((((((.(..(.((((...{{..)))).)(...(((((...(((((((.....(((.....))).....)))))))...))))).....)(((.(((.....))).)))..)..))).))))..)))..........))).)))...).............)))))))).)))..)).....((......)).)))).((.(.....).))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((.((((.(((.....((..(....((((()))))....).)).....((.((((..((()))..)))).)).))).))))......)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((....))))......))))))).}.(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....))....(((((.....]..)))))....(((((..(((.((......(((..((((((..(((((.((((((((..(((((((.(((((((((..........(((((...(((..(.((....)).)..))).............))))).))))))).)).)))))))...(((((.....((((...((.((((...((.((..(..((...((((((.....))))))..))..).)).))...)))).))...............(((.(..((((...(.......(......((((((.((.((...((.(((.((....)).))).))...)).))))))))....).....)...)))).).)))..))))..))))).....))))))))..)))))..(((......[)).)(.((((..........])))).)([((...((..(((.(.(((.((.......)).)))...).((][.[[[))....)))..))...((((.(((.....{...))).)))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)).))).......((.(.(.((((((...((.......))...))))))...)).).).......(((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....))))).)...))).))....(((((((....))).))))..>.))..))).)))))........(((.((((..((((.(.(((((......(....)......))))).)(((((...((((...((((((((((}}..)))))..)))))...)))).))))).((((....(((.....}.......)))....)))).))))....)))).)))........((...((((((((((.......((.............(((((((......))))))).........).)...............(((((((.(((...((..((.(..........).))..))......))))))))).).................)))))).).)))))...((((.(..(.......)..).....((.((((((.(......((((....((((........))))...)))).....)....)))).)).))..))))... Structure of the D. melanogaster 80S ribosome; 28S ribosomal RNA 4v6w A9 30 6.0 URS0000243D00_7227 23636399 7227 ugcuuggacuacauaugguugaggguugua .............................. .............................. Structure of the D. melanogaster 80S ribosome; 2S ribosomal RNA 4v6w A7 120 6.0 RF00001 URS000016432F_7227 23636399 0003735 0005840 7227 gccaacgaccauaccacgcugaauacaucgguucucguccgaucaccgaaauuaagcagcgucgcgggcgguuaguacuuagaugggggaccgcuugggaacaccgcguguuguuggccu <<<<<<<<<.....<<<<<<<.....<.<<<..............>>>...>....>>>>>>.>.<.<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>.>>>>>>>>>>.. (((((((((.....(((((((.....((((((...(....)...))))..))....)))))).).(.(((((.....((.((..((....)).)).))....))))).)))))))))).. Structure of the D. melanogaster 80S ribosome; 5S ribosomal RNA 4v6w A8 123 6.0 RF00002 URS000061394B_7227 23636399 0003735 0005840 7227 aacucuaagcgguggaucacucggcucaugggucgaugaagaacgcagcaaacugugcgucaucgugugaacugcaggacacaugaacaucgacauuuugaacgcauaucgcaguccaugcug ........................................<<<.<<<((....>>>......<.<<<<.....))...........>>>>..>...>>>....<<.....>>........... ........................................((((((.[[.....))).....(.((((.....]]...........))))..)...)))....((.....))........... Structure of the D. melanogaster 80S ribosome; 5.8S ribosomal RNA 4v6x B2 1861 5.0 RF01960,RF01959,RF00177 URS00005A14E2_9606 23636399 0003735 0005840 9606 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucgcuccucucccacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucagaucaaaaccaacccggucagccccucuccggccccggccggggggcgggcgccggcggcuuuggugacucuagauaaccucgggccgaucgcacgccccccguggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcgggcgggcgguccgcgagccaccgcccguccccgccccuugccucucggcgcccccucgaugcucuuagcugagugucccgcggggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggucggcccacggcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<...[[[[>>>>>[[[.((((((.....{{.........[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[......{{....[[[....................<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<<<....>>>>>>...>>>>[[..(((((.....<<<<<<<<<<<<.<..<<<<<<<<<<<<<....>>>>>>>>>.>>>>....>>>>..............)))))......]]...<<<<.<<<<......>>>>>>>>....]]]...}}....]]].<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>......}}.......<<<<<<<<<.<<<....>>>.>.>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..)))))).]]]............{{.......{{...[[[.[[....<<<.<.<<<<<<<<<<<.<<>>....>>>>>>>>>>>.>.>>>...<<...<<<..<<<<<...<<<<<<<......>>>>>>>....>>>>>.>>>.>>..<<<<<..<.......<<...<.......>.<<<<.......>>>>...>>......>..>>..>>>.......[[....(((((((.....>>>>>>>>>.)))))))...]]....]]....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>.>.>>.......<<....>>...>>>>..>..>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<..}}>>...>>.....>>>.....<<<......<<<......>>>....>>>..]]]]..<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<......<<<<<<.......<<.<<<........>>>.>>.....>>>>>>.<.<<.<<<..<<<<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<....<<<..<<<<....>>>>.>>>....>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>...>.>>>>>>>>......>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>............<<<<<..........>>>>>...........>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<.<<<<<<<<<<<<.....>>>>>>>>>>>>...>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((..((....((....((..........))...)){))......(((.......(((.(....((....(((....................((.....((.(((.....))).))......)).........((((...((((((....))))))...))))((..(((((.....[[[[[[[[[(((....(((((.(.(((((....))))).).).)))).....)))....(......)..)))))......)).(.((((..(((......))).)))))...)))...))..).))).(((.<..(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)...)).).....(((.(((((.(((....))).).))))..)))......((..(...........)..)).........((((([[......((((.....((..]])).......)))).)))))..)))))).)))..{......(.({{...(.(.((...(((..(.....((.(.((.((((((((.(..)....)))))))).)).).))....((.(..(((.(((((...((..(..........)..))....))))))))).))..(((((..(.......((..((.......))..((.......)).....))......)..))..))).......((.(..(.((.((.....]]]]]]]]].)).)).)..)))....)....(((.((...(...((((..((..((((((((...((........))......))))))))..)).......((....))...))))..)...))..))..))))...)).)....((((((....(...((((.........))))...).))))))..........(((.((..((..(.((((((.(((........))))))))).)..))....((..}}))...))...}.))))).).(((....>.((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((...(...((((..((((..(.(((.(.(((....)))).))).)..))))..))))..)..(..(((((.....)))))....)...)))....))).))).....).))))).....).)))))...)).)))).))).(...((.(((........(.......(((.(.((....)).).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....((((((.(.......).))))))......))...)))))))))).))..(.(..((.(..((((.((..(.((((.(((.(((..(.((..(...((.((((((((.(((.((.....)).))).))))).).)).))...)..)).)..))).))).)))))..)).))))...).))...)..)..(((((((((....)))))))))......... Structure of the human 80S ribosome; 18S ribosomal RNA 4v6x BC 75 5.0 RF00005 URS0000326EAC_9606 23636399 0030533 0006412 9606 agcagaguggcgcagcggaagcgugcugggcccauaacccagaggucgauggaucgaaaccauccucugcuacca <<<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((....[..)))).(((((.......))))).....(((((..]....)))))))))))).... Structure of the human 80S ribosome; E-tRNA 4v6x A5 4298 5.0 RF02543,RF02540 URS000075EC78_9606 23636399 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcggcccggcggaucuuucccgccccccguuccucccgaccccuccacccgcccucccuucccccgccgccccgggcuccggcgggugcgggggugggcgggcggggccggggguggggucggcgggggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucggggggccccguccguccguccggcggcggcggcggcggcgggaccgaaaccccccccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcgcucuccccccucccggcgcccacccccgcggggacucccccgcgggggcgcgccggcgucuccucgugggggggccgggccaccccucccacggcgcgaccgcucucccaccccuccuccccgcgcccccggggugccgcgcgcgggucggggggcggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccgggggagguucucucggggccacgcgcgcgucccccgaagagggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcagacccgacgcacccccgccacgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagcggcgggggcggcgcgcgcgcgcgcgcguguggugugcgucggagggcggccuccucccgcccacgccccgcuccccgcccccggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcugggucggucgggcuggggcgcgaagcggggcugggcgcgcgccgcggcuggaucuggacgcgagccgggcccuucccguggaucgccccagcugcggcgggcgucgcggccgcgcgguuccgcgcggcgccucgccucggccggcgccuagcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacaugagagguguagaauaagugggaggcccccggcgcccccccgguguccccgcgaggggcccggggcgggguccgccggcccugcgggccgccggugaaauaccacuacucugaucguuuuuucacugacccggugaggcgggggggcgagccccgaggggcucucgcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccggucccccgccuguccccgccggcgggccgcccccccccuccacgggagggcgcgugccccgccgcgcgccgggaccgggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuuguc .........................<<<<<<.....<......>......>>>>>.>...{.....<<....>>..<<<<<<.....<<.....>>....>>>>>>..[[[....<<<...<<<<<<<<<<<...>>>>>>>.>>>>.....>>>....<<<<<<<<<<...<<<<<<<<.<<<....<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>>>>>>>>>>>>..>>>>>>>>>>.......<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]....}.............................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<.<....<<<<<<<<.<<<.....<<<<<<<<<<<...<<<....<<<<<.<.....<<<<.<<<..<<<<<<<<<<<....<<<<<.<<<<....<<<<<<<.<<<<<<.<<<<<<<.<<<>>>...>>>>>>>.>.>>>>>.>>>>>>>.>>>>.>>>>>.>>>>>..>>>>>>>>>>>>>.>>>.>>>......>>>.>>>>>>>>>>>......>>>.>>>.>>>>>..<<<<<<<<.<<<<<<<<<..<<<<..........<<<.<<<<...<<.<<<<<<<<.<<<<<<.<<<.<<<.<<<.>>>>>>>>>>>>.>>>..............>>>>>>>>>.>....>>>>.>>>............>>>>....>>>>>>>>>.................<..<<<<...<<<<<<<..<<<<<<...<<<<<<<<<<<....>>>>>>>>>>>.>>>>>><........>..>>>>>>>...<<<<.<<<<..<<<<<<<<<<<<<<<<...<<.<<<...<<<..<<<<<<<<<>>>>.>>.>>>...>>>..>>>>>.<<<<<<<.<<<<....>>>>.>>>>>>>>>>.>>>>>>>>>>>.>>....>.>>>.<<....>>...>>>>.......<<<<<<<<.....>>>>>>>>.........>>>>.>....>>>.>>>>>...>>>>...>>>>>>>>..<<<<........>>>><<<<<<...<<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<<....>>>>>>>>..<<<<<...<<<..<<<...(((..[..>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>>.<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<...........................<<.<<<<<<<<<...<<<....<<<....<<<...<<<<<.<.....>.>>>>>.>>>....>>>..>>.>...>>>>>>>...<<<<<<<<<.........>>>>>>>>>...>>.>>.>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<...........]..))).......................<<<.<.<<<.<<<<<<.<<.<<<<<..<<>>.>>>>>.>>.>>>>>>.>>>..>.>>>.......................>>>>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....(.<<<<<<...<<....<<<....>>>..........<<.<<<<<<<<<...>>>>>>>>>>>......>>....>>...<<<<<........>>>>>.)<<<<....<<<<...<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..{{{..>>>>>>.....<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>......<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>..>>>.>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<...............<<<<<...............>>>>><<.<<<<<<<<<<<...<<<<<<...<<<<<<<....<<<<<<..<<<<.<<.<<<<<<.<<<<<>>>>>.>>>>.>>>>.>>>>.>>>>>>....>>>>>>>.....<<<<<<<<<<<<<.<<<<>>>>.....>>>>>>>>>.>>>>.>>>>>>........>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<...<<.....<<<<....>>>>.....>>.>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<<.<<<<<<<<<<<<.<<<<..........<<<<<...<<<<...<<.<<.<<<<<<...<<<<....>>>>.>>>>>>.>>.<<<....>>>...>>>>>>.............>>>>>.>>>>.>>.>>>>>>>>>>...<<<<<.....<<<<...<.<<<<<<....>>>>>>>...............<<<<<<<<<<<.....>>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))]......((((((..(((..>>>>>>.)))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]].....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<.}}}..>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.....<<<<<<<.<<..<<<.....<..........<<<<<..<<<<<...<<<<<<<<<<<<<<<<<<<...<<..<<<<.<>>>>>>>.>>>.>.>>>>>>>.>>>..>>>>>>>>>>.>>>>>........>.........<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>....................>>>..>>>>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<....<<<<<......>>>>>...>>>>....>>....>>>>.>>>.>>..>>>>>... .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(.(..(((((.((((((...))))))..))))....)).).....(((((((((...((((((((.((.....((((((((..({((((......)))))....[[(...).(((....}]])))...).))))))).))))))))))..)))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((..(...((((((((.(((.....(((((((((((.(.(((.(..(((((.((.....(((..((..(((((((((((.....((((.((((....(((((((.(((..(.(((((((.((()))...))))))).)...))).))))))).)))).))))..)))))..)))))))).))).)))).)))..)...)))))))))))))))......))).))).)))))..((((((((.((((((((((.((((.........((((.((((......((((((((.((((((.(((.(((.(((.)))))))))))).)))..............)))))))).......)))).))))...........))))...)))))))))).................(..(((((..(((((((..((((((...(((((((((((....))))))))))).))))))(........)..)))))))...((((.((((..((((((((((((((((...((.(((...(((.(((((((((()))).)).))).).)))..)))))..((((((.((((....)))).)))))).))).))))))))))).))....).))).((....))...)))).......((((((((.....))))))))........))))).)....))).)))))..).)))...))))))))..((((........))))((((((....(((((((((((((..(((.((.(((........)))).)...)))...((....))...((((((((....))))))))..(((((...(((..(((....[[...[.)))..)))....))))).(((((.(((.((((......))))))).))).))....)))))))))))))..((.(...((((((.....(((((((((..((.....(((((((....)))))))....<.))...(((..((.((........)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((...........................((.((((((((....(((....(((..(.(((....((((.(.....).))))..))).)..)))..)).)....))))))...(((((((((.(......))))))))))...)).)).)))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.......(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((..........]...]]........................(((.(.(.(.((.(((.(..(((((..(..).)))))..).))).)).).)..).))).......................)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...((....(((....)))..........((.((((.(.((...)).).))))))......))....))...(((((........)))))]]((((....(((....(((.((((....)))).))).((((....)))...(...((((((...(((((((.((((((((((.((((...{{..)))).)....(.(((.((((.((((.....(((.....))).....))))))))..))).).....(((.((((....).))).))))))).).)))).)))))))(...)....))))))...))............))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((...(((.((...(((((((.....((((...((((.((.((((((.(..(())..).)))).)))).))))..)))).....))))))).....((((((((.((((((((())))..)..)))).)))).)))).)).)))........)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(...(......((((....))))......).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....))....(((((........)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.((((.((((..........(((((...((((.[.(..((.((((((...((((....)))).)))))).)).(.(....).)...]))))).............))))).)))).)).)).)))))))...(((((.....((((..((.((((((....))))))))...............((((((((((.....))))))))))...))))..))))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....)))))))...(((.(((((....{..)))).)))).((......)).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))....))..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}..)))))..)).))...))))...)))).((((...((((.............))))...))))..)))...).))))))......((((((.((..((......(..........(((((..(((((...(((((((.(((((((((((...(((..(((...)))))).))).).)))))))..))..)))))))))).)))))........)......(..((((....((((.(((((((......)))))))))))...))))..)..................))..)))))))).(((((.(..(.......)..)....((.(((((((..(.....((((.(..(((((......)))))..)))))....).....)))).))).))..)))))... Structure of the human 80S ribosome; 28S ribosomal RNA 4v6x A7 121 5.0 RF00001 URS00000F9D45_9606 23636399 0003735 0005840 9606 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuuu <<<<<<<<<....<<<<<<<<.....<<<<<<............>>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>... (.(((((((....((((((((.....((((((...(....)...))))..))....)))))).))(((((((.....((.((..((....)).)).))....)))))))))))))).)... Structure of the human 80S ribosome; 5S ribosomal RNA 4v6x A8 157 5.0 RF00002 URS0000005270_9606 23636399 0003735 0005840 9606 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcuu .........................................<<<<<<<<<....>>>>.....<.<<<......>>.............>>>..>...>>>....<<<..>>><<<<<<<<.......>>>>>>>>..................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....)).((((.((.......)).))))...................... Structure of the human 80S ribosome; 5.8S ribosomal RNA 4v6y AA 1530 12.0 RF00177,RF01959,RF01960 URS000080E246_83333 24186064 0003735 0005840 83333 ugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggauca ....<<<<..[.((((.>>>>.<<<...<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<<....>>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<......>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<.<<<<....>>>>....>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<.......<<<....>>>......>>>>...<.<<<<<......<.<<<<...<.......>...>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>..>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>..>>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<........<<<....>>>......>>..)))).]<<<<<.<<<<<<<.<<..<<<<...<<<<<<<<<.......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<..<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>.........>>>.........>>>...>>>>>>>>>...>>>>>>>....>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>......>>>>.....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<.....<<<<.<.<<<<..<<....>>.>>>>>.>>>>....>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ....((((..[.[[[..)))).(..(..((((..(((((((((....(((.(((..(((..((.((..(((((((((((..)))))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..(((.((((....))))....)))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(...((((....(.......)....))).)...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..))))..).)..........((([[...(.((((...(((.(((((((.((((((((((......((.(((.....))).))....))))))))..)))))))))..(((((.(((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))..))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((.((((((((.....)))))))).)))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((..(((((((....)))))))...((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....))))))))..)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(.....((((((........)))))).....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((......(((((.((((..((....)).))))))))).....)))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... E. coli 70S-fMetVal-tRNAVal-tRNAfMet complex in classic pre-translocation state (pre1a); 16S ribosomal RNA 4v6y A1 76 12.0 RF00005 URS00003179F7_83333 24186064 0030533 0006412 83333 ggguganuagcucagcugggagagcaccucccunacnaggaggggnucggcggnucgaucccgucaucacccacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((........)))).(((((.......))))).....(((.(.......).)))))))))).... E. coli 70S-fMetVal-tRNAVal-tRNAfMet complex in classic pre-translocation state (pre1a); fMet-Val-tRNA-Val 4v6y A2 15 12.0 URS000080E284_32630 24186064 32630 acuaugguuuuuauu ............... ............... E. coli 70S-fMetVal-tRNAVal-tRNAfMet complex in classic pre-translocation state (pre1a); 5'-R(*AP*CP*UP*AP*UP*GP*GP*UP*UP*UP*UP*UP*AP*UP*U)-3' 4v6y A3 77 12.0 RF00005 URS000041AF00_83333 24186064 0030533 0006412 83333 cgcggggnggagcagccuggnagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... E. coli 70S-fMetVal-tRNAVal-tRNAfMet complex in classic pre-translocation state (pre1a); tRNA-fMet 4v6y BA 2903 12.0 RF02540,RF02541 URS000080E25C_83333 24186064 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>.............}....>>>>>>>>>>>.......<<<...<<<<<......>>>>>...>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<......<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.......>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<<..<<<.........>>>..>>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><.<<<<<...<<<<.....<<<<<<<<....>>>>>>>>..>>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>>.<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>....<<<<<....>>>>>....>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<..<<....>>...>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<<<<<..<<.........<.<<<<....>>>>.>......>>............>>>>>...>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<.........>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<<...>>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...)..((.....]]))....)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(..{.....).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...((..(((((........))))).))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((...(((((((((.....(((...(((.((((...(((((((.....))))).))...)))).)))..)).).....)))))).)))...))))))).)...((((((((((......))))))))))....(((....}.)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(((((((...(((......((((((((....))))))))...)))..))))).)).....))))))(......((.....((((((.......))))))((((....((((..((...((((((...((.....)).)))))).....[(((..((.(.(((...(((....)))...)))..)))...(((((........)))))].(((((((((((((...((((....((((..(((..(((((((((((....{{{...))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).)))..)).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(.(((..)])).)...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((..(((((..(((((.(((.(((((.((((((.((((.((((.(.........((.((..((........((..(((....)))..)).....))............)).))).)))).)))).))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))(.((...(((((((...(((((.........))))).....((.[.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..).))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).)).....((((((....))).))).....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))).).(((((...((((...(((((((((((}}}.))))))..)))))...)))).))))))..(((....((((.....}.......))))....))).))))..]....)))))))(.((((((...))))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). E. coli 70S-fMetVal-tRNAVal-tRNAfMet complex in classic pre-translocation state (pre1a); 23S ribosomal RNA 4v6y BB 117 12.0 RF00001 URS0000366A67_83333 24186064 0003735 0005840 83333 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggc <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>> (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))) E. coli 70S-fMetVal-tRNAVal-tRNAfMet complex in classic pre-translocation state (pre1a); 5S ribosomal RNA 4v6z AA 1530 12.0 RF00177,RF01959,RF01960 URS000080E246_83333 24186064 0003735 0005840 83333 ugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggauca ....<<<<..[.((((.>>>>.<<<..<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<<....>>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<......>>....<<<<<<..........>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<............>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>..<<.<<<<<........<<<<<<.<.......>>>.>>>>..........>>>>>....>>.<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>.>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<....<.<<<<<<.....>>>>>>.>..>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<.......<<<....>>>.....>>>..)))).]<<<<..<<<<<<<.<<..<<<<...<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<..<.....<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<..<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>.........>>>.....>....>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>...........>>>>.....<<<<<<<.........>>>>>>>......>>...>>>>>>>.>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<.<.<<<...<<....>>..>>>>.>>>>...>>>>>>>>>>>>..>>.>>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ....((((..[.[[[..)))).(((..(((((..(((((((((....(((.(((..(((..((.((..(((((((((((..)))))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((.(.(.......))..)))).....)....)))))....)..(((((.[[...(((((.....(..]]..).......))))))))))..))))).)))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((...((((((((...((........))......))))))))...).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...(((.((..((((((((((((.....))))))))))))...((..]])).....)).))))))).(((......((((....))))....)))...]]].](((.(.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))...(......)..))))).))).((.(((...((((...(....(((((((((....)))...(((......)))...)))))).....(..(.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)..).....)....))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))).).))..(.(..((.(..(((.(((..(((((((((((.....(((((..((((..((....)).)))).)))))....)))))))))))..))).)))...).))...)..)..(((((((((....)))))))))}..... E. coli 70S-fMetVal-tRNAVal-tRNAfMet complex in classic pre-translocation state (pre1b); 16S ribosomal RNA 4v6z A1 76 12.0 RF00005 URS00003179F7_83333 24186064 0030533 0006412 83333 ggguganuagcucagcugggagagcaccucccunacnaggaggggnucggcggnucgaucccgucaucacccacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((........)))).(((((.......))))).....(((((.......)))))))))))).... E. coli 70S-fMetVal-tRNAVal-tRNAfMet complex in classic pre-translocation state (pre1b); fMet-Val-tRNA-Val 4v6z A2 15 12.0 URS000080E284_32630 24186064 32630 acuaugguuuuuauu ............... ............... E. coli 70S-fMetVal-tRNAVal-tRNAfMet complex in classic pre-translocation state (pre1b); 5'-R(*AP*CP*UP*AP*UP*GP*GP*UP*UP*UP*UP*UP*AP*UP*U)-3' 4v6z A3 77 12.0 RF00005 URS000041AF00_83333 24186064 0030533 0006412 83333 cgcggggnggagcagccuggnagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... E. coli 70S-fMetVal-tRNAVal-tRNAfMet complex in classic pre-translocation state (pre1b); tRNA-fMet 4v6z BA 2903 12.0 RF02540,RF02541 URS000080E25C_83333 24186064 0003735 0005840 83333 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<<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<<...(((>>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<....<<<........>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>...>.>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>..<<<<<<<...<<<<<<<<<......<<...<<<.<<<<...<<<<<<.......>>>>.>>...>>>>.>>>..>>.......>>>>>>>.>>...>>>>>>>.....<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<<..<<<.........>>>..>>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><<<<<<<...<<<<.....<<<<<<<<....>>>>>>>>..>>>>..>>>>>.>>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....[[....>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>>...<<<<<....>>>>>....>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>..<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>...>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<.<<...<<<<...........<<<<<..<<........<<<<<<<....>>>>>>>.....>>............>>>>>..>>>>...>>.>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<.........>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<.<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>..>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<...<<<<<<<<<<<.]].>>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<.<<<...........>>>.>...>>>>.>>>>.......>>>>>>>..<<<<<<...>>>>>><....<<..<<<<.........>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((......((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((.........))))))))......(((((..[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)......)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.(.....)))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((...(((((((((.....(((...(((.((((...(((((((.....))))).))...)))).)))..)).).....)))))).)))...))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(((((((...(((......((((((((....))))))))...)))..))))).)).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))......(((..((.(.(((...(((....)))...)))..)))...(((((........)))))..(((((((((((((...((((....((((..(((..(((((((((((....{{{...))))))((..((((...(((((((((((..((.....)).)))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((((.((...((((.(.........((.((..((........((..(((....)))..)).....))............)).))).))))...)).))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).....)..(((..((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)....)).).....(((((((....))).))))....))..)))))))))))[...(((((((...((((...((((((.....(....)....))))))..(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((((.)))))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). E. coli 70S-fMetVal-tRNAVal-tRNAfMet complex in classic pre-translocation state (pre1b); 23S ribosomal RNA 4v6z BB 117 12.0 RF00001 URS0000366A67_83333 24186064 0003735 0005840 83333 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggc <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.....<.<<<<<<<<...>>>>>>>>...>...>>...>>>>>>>>> (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))) E. coli 70S-fMetVal-tRNAVal-tRNAfMet complex in classic pre-translocation state (pre1b); 5S ribosomal RNA 4v70 AA 1530 17.0 RF00177,RF01959,RF01960 URS000080E246_83333 24186064 0003735 0005840 83333 ugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggauca ....<<<<<..[((((>>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<<....>>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<......>>....<<<<<<..........>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<.......<<<....>>>......>>>>...<.<<<<<.......<<<<.<<.<.......>>>..>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<.<.<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>..>>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<.......<<<....>>>.....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<...<<<<<<<<<<.......<........>...........<<<<<<<........<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>....<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<..<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>.........>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>......>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<.....<<<<<<.<<<...<<....>>..>>>>>>>>>...>.>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>...... ....(((...[.[[[...))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((((....))))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....(((.((....)).)))......)).).....(.(....).)....((((((...(....).)))))).)))))))..)).)))))))(......(((..((((((((.......)))))))))))........)..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((..((...(((((.(.(.......))..)))).)...)..).)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...(((((((.(...(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((.(.........).))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].]((.(..(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))...((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...))))))).)..))..(.(..((.(.((((.(((..((((((((((......(((.((.((.(..((....)).).)))).))).....))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... E. coli 70S-fMetVal-tRNAVal-tRNAfMet complex in intermediate pre-translocation state (pre3); 16S ribosomal RNA 4v70 A1 76 17.0 RF00005 URS00003179F7_83333 24186064 0030533 0006412 83333 ggguganuagcucagcugggagagcaccucccunacnaggaggggnucggcggnucgaucccgucaucacccacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).(((((.......))))).....(((((..]....)))))))))))).... E. coli 70S-fMetVal-tRNAVal-tRNAfMet complex in intermediate pre-translocation state (pre3); fMet-Val-tRNA-Val 4v70 A2 15 17.0 URS000080E284_32630 24186064 32630 acuaugguuuuuauu ............... ............... E. coli 70S-fMetVal-tRNAVal-tRNAfMet complex in intermediate pre-translocation state (pre3); 5'-R(*AP*CP*UP*AP*UP*GP*GP*UP*UP*UP*UP*UP*AP*UP*U)-3' 4v70 A3 77 17.0 RF00005 URS000041AF00_83333 24186064 0030533 0006412 83333 cgcggggnggagcagccuggnagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... E. coli 70S-fMetVal-tRNAVal-tRNAfMet complex in intermediate pre-translocation state (pre3); tRNA-fMet 4v70 BA 2903 17.0 RF02540,RF02541 URS000080E25C_83333 24186064 0003735 0005840 83333 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<<<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<.[((.((.>>>.....<<<<<<<..<<<)))).].>>>......>>>>>>>...>>>....<<<....>>><<<<<<......>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<....<.<<<<<<<<<<<<<.<<<...<<<<........>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>..>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<...<<<<<........>>>>>...>.>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<....<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<<.....>>>>>.>>...>>>>.>>>..>>.>.....>>>>>>>.>>....>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.......<<<(((.....<<<<<<...........<<...<<<<..<<........<<<<<.<<<..<<<.........>>>..>>>........<<<......>>>..>>>>>....>>..>>>>..>>...........))).....>>>>>>.>>>......>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<....<<<<<...<<.....>>.>>>>>.....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<....<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>>...<<<<<....>>>>>....>>>>>...>>>.....>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>..<<<<.<<<..<<<<<<<..<<<........<<<<<..<<....>>...>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>...>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<........(...<<<<<..<<........<<<<<<<....>>>>>>>.....>>..........).>>>>>...>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<<...>>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. 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E. coli 70S-fMetVal-tRNAVal-tRNAfMet complex in intermediate pre-translocation state (pre3); 23S ribosomal RNA 4v70 BB 117 17.0 RF00001 URS0000366A67_83333 24186064 0003735 0005840 83333 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggc <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<........<<<<<<<...>>>>>>>........>>...>>>>>>>>> (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))) E. coli 70S-fMetVal-tRNAVal-tRNAfMet complex in intermediate pre-translocation state (pre3); 5S ribosomal RNA 4v71 AA 1530 20.0 RF00177,RF01959,RF01960 URS000080E246_83333 24186064 0003735 0005840 83333 ugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggauca ....<<<<....((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<<....>>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.......<.<<<....<<<<....>>>>..>>>>.>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<........<<<<<<.<.......>>>.>>>>..........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<.......<<<....>>>.....>>>..))))..<<<<<.<<<<<<<.<<..<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<..<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>.........>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>.....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<......<<<<<<.<<<<..<<....>>.>>>>>>>>>>.....>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>...... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((((....))))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(......(((..((((((((.......)))))))))))........)..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((.(.......))).)))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((.....((........))........)))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))..........((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((..(((((((....)))))))...((....))..))))).))).((.(((...((..((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((.(...((..(((.....)))))....).)))))..(..(((((.....))))).....)..)))).....).).).....)).)))))....))))))))..)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(.....((((((........)))))).....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((......((((((..(((..((....)).))).)))))).....))))))))))..))).))))..).))...)..)..(((((((((....)))))))))...... E. coli 70S-fMetVal-tRNAVal-tRNAfMet complex in intermediate pre-translocation state (pre2); 16S ribosomal RNA 4v71 A1 76 20.0 RF00005 URS00003179F7_83333 24186064 0030533 0006412 83333 ggguganuagcucagcugggagagcaccucccunacnaggaggggnucggcggnucgaucccgucaucacccacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((........)))).(((((.......))))).....(((((.......)))))))))))).... E. coli 70S-fMetVal-tRNAVal-tRNAfMet complex in intermediate pre-translocation state (pre2); fMet-Val-tRNA-Val 4v71 A2 15 20.0 URS000080E284_32630 24186064 32630 acuaugguuuuuauu ............... ............... E. coli 70S-fMetVal-tRNAVal-tRNAfMet complex in intermediate pre-translocation state (pre2); 5'-R(*AP*CP*UP*AP*UP*GP*GP*UP*UP*UP*UP*UP*AP*UP*U)-3' 4v71 A3 77 20.0 RF00005 URS000041AF00_83333 24186064 0030533 0006412 83333 cgcggggnggagcagccuggnagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... E. coli 70S-fMetVal-tRNAVal-tRNAfMet complex in intermediate pre-translocation state (pre2); tRNA-fMet 4v71 BA 2903 20.0 RF02540,RF02541 URS000080E25C_83333 24186064 0003735 0005840 83333 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.<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[.<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<....<<<........>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..))).......].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>...<<<.....>>>......>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<<.....>>>>>.>>...>>>>.>>>..>>.>.....>>>>>>>.>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<<..<<<.........>>>..>>>.........<<......>>...>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><<<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>.>>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<..<<...<<<<<....<<.....>>..>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<..<<.....>>.>>>>>>>..>>>>...>>>>...>>...<<<<<....>>>>>....>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>.>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<.<...<<<<.....>>>>...>.>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<<.<<....>>..>>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.[[..[[......<<<<.[[<<<<..<<<<..<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<..<<.........<<<<<<....>>>>>>......>>............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>...>>>>..<<<.......>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<.........>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>........<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.........<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]...]]>>>>>>>>....<<<<<<<...<<<<....<<<<<...............>>>>>...<<<<<....<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>..>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<<<...>>>>>><....<<..<<<<.........>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>.. .(((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...)..((.....]]))....)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))...(((.....)))......)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...).)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((...(((((((((.....(((...(((.((((...(((((((.....))))).))...)))).)))..)).).....)))))).)))...))))))).)...((((((.((........)).))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(...((......)).).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).)))))).....[(((..((.(.(((...(((....)))...)))..)))...(((((........)))))].(((((((((((((...((((....((((..(((..(((((((((((....{{{...))))))((..((((...(((((((((((..((.....)).)))))))..))))...))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(....).....)))))((((((......((....(((.....)))....))....))))))(...).......(((((((((...((.........))...(((((((.....(((....))).......)))))))..((((.(((..(((((((..((.........(((((..((....))...))))).........)))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((((.((((.((((.([........((.((..((........((..(((...])))..)).....))............)).))).)))).)))).))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))(.((...(((((((...(((((.........))))).....((.[.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....((.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..))....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....)))))..).((((...((((...(((((((((((}}}.))))))..)))))...)))).)))).)..(((....((((.....}.......))))....))).))))..]....)))))))(.((((((...))))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).)))))))).. E. coli 70S-fMetVal-tRNAVal-tRNAfMet complex in intermediate pre-translocation state (pre2); 23S ribosomal RNA 4v71 BB 117 20.0 RF00001 URS0000366A67_83333 24186064 0003735 0005840 83333 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggc <<<<<<<<......<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>....>>>>>>>> (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))) E. coli 70S-fMetVal-tRNAVal-tRNAfMet complex in intermediate pre-translocation state (pre2); 5S ribosomal RNA 4v72 AA 1530 13.0 RF00177,RF01959,RF01960 URS000080E246_83333 24186064 0003735 0005840 83333 ugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggauca ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<<....>>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>..<<<...>.>>....>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<........<<<.<<.<.......>>>..>>>..........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<.<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>..>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<....<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<..<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>.........>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>...........>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<...<<....>>..>>>>>>>>>...>>>>>>>>>>>>..>>.>>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ....[[....(.(((....]].((((.(((((..((((((.((....(((.(((..(((..((.((..(((((((((((..)))))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((..(......).)))))))))......)))..((((((((....))))...))))))).((((..............))))..(((....)))....)))))).).....(.(((...(((((....)))).))))).)..))))))..((((......((((....)))).....))))..((.(((((...(....(((..(.(.......))...))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[.....((((...(((.(((((((.((((((((((......((((((.....))))))....)))))))))..))))))))..(((((.(((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..)))..))))..))))...))))....((((((...((...((((.........))))...))))))))......{...(.((((..(((.((((((((.....)))))))).)))...((..]])).....))))..)))).(((......((((....))))....)))...))).)(((((.(((.(((.(((.(((((..((((((((((......((........))........(.(((((((..(...(((((((..(((((((....)))))))...((....))..))))).))).((.(((...((((.(.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).)..))...)).)))))....))))))))..)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(.....((((((........)))))).....)..)..))))))....(((((((.........)))))))......))...))).)))))).))..(.(..((.(.((((..((..((((.(((((((......(((..(((...((....))..))).))).....))))))).))))..))..))))..).))...)..)..(((((((((....)))))))))}..... E. coli 70S-fMetVal-tRNAVal-tRNAfMet complex in hybrid pre-translocation state (pre4); 16S ribosomal RNA 4v72 A1 76 13.0 RF00005 URS00003179F7_83333 24186064 0030533 0006412 83333 ggguganuagcucagcugggagagcaccucccunacnaggaggggnucggcggnucgaucccgucaucacccacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((........)))).(((((.......))))).....(((((.......)))))))))))).... E. coli 70S-fMetVal-tRNAVal-tRNAfMet complex in hybrid pre-translocation state (pre4); fMet-Val-tRNA-Val 4v72 A2 15 13.0 URS000080E284_32630 24186064 32630 acuaugguuuuuauu ............... ............... E. coli 70S-fMetVal-tRNAVal-tRNAfMet complex in hybrid pre-translocation state (pre4); 5'-R(*AP*CP*UP*AP*UP*GP*GP*UP*UP*UP*UP*UP*AP*UP*U)-3' 4v72 A3 77 13.0 RF00005 URS000041AF00_83333 24186064 0030533 0006412 83333 cgcggggnggagcagccuggnagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... E. coli 70S-fMetVal-tRNAVal-tRNAfMet complex in hybrid pre-translocation state (pre4); tRNA-fMet 4v72 BA 2903 13.0 RF02540,RF02541 URS000080E25C_83333 24186064 0003735 0005840 83333 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<<<<<<<<......<<<<<<.<<<<....<<<..<<<<<<<<<<.<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>(.......<<<......)>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>..>>>.......>.>>>>>>>.>>...............<<....>>....>>.........<<<<.....>>>>.............>....>>>>.>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<<.<.......>.>><<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>...>.>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<<.....>>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<<..<<<.........>>>..>>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>......<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>..<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....[[[...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>>...<<<<<....>>>>>....>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>..<<<<.<<<..<<<<<<<..<<<........<<<<<..<<....>>...>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>...>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.<<......<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<<<<<..<<......<.<<<.<<<....>>>.>>>>....>>............>>>>>...>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>....<..<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.>.....<<<<<.<.<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>...>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]].>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>.>.>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((..((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....))..)))))).....(.((((..((((........))))..)))).[.(..(.......).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...((..(((((........))))).))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((...(.(((((((.....(((...((..((((...(((((((.....))))).))...))))..))..)).).....)))))).).)...))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.......(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).)))))).....[(((..((.(.(((...(((....)))...)))..)))...(((((........)))))].(((((((((((((...((((....((((..(((..(((((((((((....{{{...))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((.(((.(((.((......((((.((((((..(((((.(((.(((((.((((((.((((.((((.([.....{..((.((..((........((..(((...])))..)).....))..........}.)).))).)))).)))).))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))(.((...(((((((...(((((.........))))).....((.[.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))....(..((((.(.((((((...((.......))...))))))...)))).).....)..((((.(.((((..(((((((((......))))))..))).(((((.....))))).....))))...)...))).).....(((((((....))).))))....))..)))))).))))[...(((((((...((((..(((((((.....(....)....))))))).(((((....(((...(((((((((((}}}.))))))..)))))...)))..)))))...(((....((((.............))))....))).))))..]....)))))))(.((((((...))))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). E. coli 70S-fMetVal-tRNAVal-tRNAfMet complex in hybrid pre-translocation state (pre4); 23S ribosomal RNA 4v72 BB 117 13.0 RF00001 URS0000366A67_83333 24186064 0003735 0005840 83333 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggc <<<<<<<<<.....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>> ((((((.((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)).)))))) E. coli 70S-fMetVal-tRNAVal-tRNAfMet complex in hybrid pre-translocation state (pre4); 5S ribosomal RNA 4v73 AA 1530 15.0 RF00177,RF01959,RF01960 URS000080E246_83333 24186064 0003735 0005840 83333 ugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggauca ....<<<<...[((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<............>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..........>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<.....<<<<....>>>>...>>..>>.>>>>>>..<<<<.......<<<....>>>......>>>>...<.<<<<<......<.<<<<<<.<.......>>>.>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<.<<<<<<<.....>>>>>>>.>>>>>..<<..))>>.....>>>>>>.>>>.<<<.......<<<....>>>.....>>>..)))).]<<<<<.<<<<<<<.....<<<<...<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<<..>>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<..<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>.........>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>...........>>>>.....<<<<<<<.........>>>>>>>...........>>>>>>>>>>.>>.......<<.<.<<<<..<<..<<<<<<<<<<<.....<<<<<<.<<<...<<....>>..>>>>>>>>>....>>>>>>>>>>>..>>..>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>...... ....((((...[[[[..)))).((((.(((((..(((((((.(....(((.(((..(((..((.((..((((((...((..))...))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..........)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.((......(((....)))....)))..).))))))..((((......((((....)))).....))))..((.(((((...(....((((((.(.......))).)))).....)....)))))....)).(.((([[[...(((((.....((.]]])).......)))))))).)..)))))))))..........((([[...(.((((...(((.(((((((.((((((((........((((((.....))))))......))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((.(.((((((.....)))))).).)))...((..]])).....)))))))))).(((......((((....))))....)))...]]].]((((..(((((((..(..(((((..((((((((((......((........))........(.(((((((..(...((((((...(((((((....)))))))...((....))...)))).))).((.((....((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...))..))))....))))))))..)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......)....))))))).)).))..(.(..((.(.((((.(((..(((((((((((.....(((((...(.(..((....))..))..)))))....)))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... E. coli 70S-fMetVal-tRNAVal-tRNAfMet complex in hybrid pre-translocation state (pre5a); 16S ribosomal RNA 4v73 A1 76 15.0 RF00005 URS00003179F7_83333 24186064 0030533 0006412 83333 ggguganuagcucagcugggagagcaccucccunacnaggaggggnucggcggnucgaucccgucaucacccacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).(((((.......))))).....(((((..]....)))))))))))).... E. coli 70S-fMetVal-tRNAVal-tRNAfMet complex in hybrid pre-translocation state (pre5a); fMet-Val-tRNA-Val 4v73 A2 15 15.0 URS000080E284_32630 24186064 32630 acuaugguuuuuauu ............... ............... E. coli 70S-fMetVal-tRNAVal-tRNAfMet complex in hybrid pre-translocation state (pre5a); 5'-R(*AP*CP*UP*AP*UP*GP*GP*UP*UP*UP*UP*UP*AP*UP*U)-3' 4v73 A3 77 15.0 RF00005 URS000041AF00_83333 24186064 0030533 0006412 83333 cgcggggnggagcagccuggnagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... E. coli 70S-fMetVal-tRNAVal-tRNAfMet complex in hybrid pre-translocation state (pre5a); tRNA-fMet 4v73 BA 2903 15.0 RF02540,RF02541 URS000080E25C_83333 24186064 0003735 0005840 83333 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.<<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[.<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((...<<<......<<<<<<<<<<<<<.<<<....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>.........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..))).......].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>...>.>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>..<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>>.>>...>>>>>>>.....<<<<<<<<<........>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<((......<<<<<<...........<<..<<<<<..<<........<<<<<.<<<..<<<<.......>>>>..>>>........<<<......>>>..>>>>>....>>..>>>>>.>>............)).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>...<<<<........>>>>.))<<<<<<<<<<<.<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>>...<<.<<....>>.>>....>>>>>...>>>...>>>.>........>>>>...>.....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<......<<<...<<<<.....>>>>...>>>....>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>.>......>>>>>>>>..>>>>><<<<<.........>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.........<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<..<<........<<<<<<<....>>>>>>>.....>>............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<.........>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>........<<<...<<<<<<...<<.......>>...>>>>>>....>>>.........<<<<<..<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>......>>>.>>....<<<<<<<....>>>.>>>>........)))>>>>>>>>....<<<<<<<...<<<<...<<<<<<...............>>>>>.>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<<...>>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>.. ((((((((......((((((((((.....(((..(.(((((((((((......((((((.[..[[[.))).....(((((....(((]]]..].)))........)))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(.(...(((((......)))))[[(...).(((.....]])))...).)...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).)))))))..)...............((....))....)).........((((.....)))).............).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...(((..).))...)))...((....))..(((.......))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))..((((((....(((((((((.....(((...(((.((((...((.((((.....))))..))...)))).)))..)).).....))))))).))....)))))).....(((((((((........)))))))))....(((......)))...((((.(((...((([[....(.((((((.....(.....((..(((((..(((.......(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))............]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((.(.(((......((((((((....))))))))...))).))))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).)))))).....[(((..((.(.(((...(((....)))...)))..)))...(((((........)))))].(((((((((((((...((((....((((..(((..(((((((((((....{{{...))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(...((((....))))....))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..((.........(((((..((....))...))))).........)))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.(.......((((.((((((..(((((.(((.(((((.((((((.((((.((((..[........((.((..((.........((.(((...]))).))......))............)).))..)))).)))).))))))...(((.((((((.....)))))))))....))))).)))..)))).).(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).)))).....)..)))))))))))[...(((((((...((((...(((((......(....).....)))))..(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.((((((...))))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). E. coli 70S-fMetVal-tRNAVal-tRNAfMet complex in hybrid pre-translocation state (pre5a); 23S ribosomal RNA 4v73 BB 117 15.0 RF00001 URS0000366A67_83333 24186064 0003735 0005840 83333 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggc <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<.....>>>>>>>.......>>...>>>>>>>>> (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......(((((((.....))))))).......))...))))))))) E. coli 70S-fMetVal-tRNAVal-tRNAfMet complex in hybrid pre-translocation state (pre5a); 5S ribosomal RNA 4v74 AA 1530 17.0 RF00177,RF01959,RF01960 URS000080E246_83333 24186064 0003735 0005840 83333 ugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggauca ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<..<<....>>..>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..........>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>...<<<<<........>>...>>>..>>.<<<<<............>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<.......<<<....>>>......>>>>...<.<<<<<........<<<<...<.......>...>>>>..........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<.......<<<....>>>.....>>>..)))).]<<<<<.<<<<<<<.<<..<<<<...<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<........<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>...<.<<<..<<<<<<....<<..<<<.....>>>>>.....>>>>>>.....<<<<<.....>>>>>.........>>>.>........>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<..<..<<<<<<........>>>>>>.>...>......>>>>.....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<...<<<<.<<<..<<<<<<<<<<<.....<<<<<<.<<<<..<<....>>.>>>>>>>>>>....>>>>>>>>>>>..>>>.>>>>....>>...>.....<<<<<<<<<....>>>>>>>>>...... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((((.(((..))).)))).)))))..)))))......(((......(((.(((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..(......))))))).)))))))..)).))).)))(((....(((..((((((((.......)))))))))))......)))....((...(....)......))..))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((.(.(.......))..)))).....)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((.(.........).))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((.......(((....))).....)))...]]].](((((.(((.(((.((..(((((..((((.(((((......((........))........(.(((((.(..(...(((((((..(((((((....)))))))...(......)..))))).))).((.((....((((.(.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).)..))...))..))))....).))))))..)).))).)))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...))).)))))).))..(.(..((.(.((((.(((..(((((((((((.....((((((.((((..((....)).))))))))))....)))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... 70S-fMetVal-tRNAVal-tRNAfMet complex in hybrid pre-translocation state (pre5b); 16S ribosomal RNA 4v74 A1 76 17.0 RF00005 URS00003179F7_83333 24186064 0030533 0006412 83333 ggguganuagcucagcugggagagcaccucccunacnaggaggggnucggcggnucgaucccgucaucacccacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).(((((.......))))).....(((((..]....)))))))))))).... 70S-fMetVal-tRNAVal-tRNAfMet complex in hybrid pre-translocation state (pre5b); fMet-Val-tRNA-Val 4v74 A2 15 17.0 URS000080E284_32630 24186064 32630 acuaugguuuuuauu ............... ............... 70S-fMetVal-tRNAVal-tRNAfMet complex in hybrid pre-translocation state (pre5b); 5'-R(*AP*CP*UP*AP*UP*GP*GP*UP*UP*UP*UP*UP*AP*UP*U)-3' 4v74 A3 77 17.0 RF00005 URS000041AF00_83333 24186064 0030533 0006412 83333 cgcggggnggagcagccuggnagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(((((.......)))))))))))..... 70S-fMetVal-tRNAVal-tRNAfMet complex in hybrid pre-translocation state (pre5b); tRNA-fMet 4v74 BA 2903 17.0 RF02540,RF02541 URS000080E25C_83333 24186064 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<........>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>...>.>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>.......>>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<<.....>>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<....<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<<..<<<.........>>>..>>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>....>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>......<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>..<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<..<<.....>>.>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<...<<.........>>...<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.......<<<<<<.<<....>>..>>>>>>.....>..>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<..<<<<<<<<<<<.<<<<...........<<<<<..<<........<<..<<<....>>>..>>.....>>............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>.....>>>>.>>>..>>>>>...<<<.....>>>.<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<.<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>..>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<....<<<<<...............>>>>>...<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<<<...>>>>>>.....<<..<<<<.........>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...).)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((...(((((((((.....(((...(((.((((...(((((((.....))))).))...)))).)))..)).).....)))))).)))...))))))).)...((((((((.(......).))))))))....(((......)))...((((.(.....((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.((([.(((.........)))..))).....(].(((......)))).)))))...)))..))))).))...........]]].)...)))))))))).....)))))(((((((((....)))))))))....))))))(.((.((...(((......((((((((....))))))))...)))..)).))..).....))))))(.(....((.....((((((.......))))))((((.<..((((..((..(((((((...((.....)).))))))......(((..((.(.(((...(((....)))...)))..)))...(((((........)))))..(((((((((((((...((((....((((..(((..(((((((((((....{{{...))))))((..((((...(((((((((((..((.....)).)))))))..))))..[))))...))(..(((((....)))))...))))))..>)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....(((((((..((..(....(.......(((((....(....).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((...((.........))...(((((((.....(((....))).......)))))))..((((.(((..(((((((...(.........(((((..((....))...))))).........).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..)))..))))))).))))))....))).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((..((((.((((.(.........((.((..((........((..(((....)))..)).....))............)).))).)))).))))..)))))...(((.((((((.....)))))))))....))))).)))..)))))...((......[)).((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].]......((((((.((..]]]]..))))))))......)}......))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(.(((((.....(....)....)))))...(((((...((((...(((((((((((}}}.))))))..)))))...)))).))))))..(((....((((.....}.......))))....))).))))..]....)))))))(.((((((...))))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). 70S-fMetVal-tRNAVal-tRNAfMet complex in hybrid pre-translocation state (pre5b); 23S ribosomal RNA 4v74 BB 117 17.0 RF00001 URS0000366A67_83333 24186064 0003735 0005840 83333 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggc <<<<<<<<......<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>....>>>>>>>> ((((((((......((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))....)))))))) 70S-fMetVal-tRNAVal-tRNAfMet complex in hybrid pre-translocation state (pre5b); 5S ribosomal RNA 4v75 AA 1530 12.0 RF00177,RF01959,RF01960 URS000080E246_83333 24186064 0003735 0005840 83333 ugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggauca ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<.<....>.>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<............>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<.......<<<....>>>......>>>>...<.<<<<<.......<<<<<<<..........>>.>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<....<.<<<<<<.....>>>>>>.>..>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<..<<<<<<<.<<..<<<<<.<<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<.<.....<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<..<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>.........>>>.....>...>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.>...<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>.....<<<<<<<.........>>>>>>>......>>...>>>>>>>.>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((.((..)).))))).)))))..)))))......(((......(((((((...(...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)..)))))))(((....(((..((((((((.......)))))))))))......)))..((((((.(....).))...))))))).(((((............))))).((((....))))...)))))).).....(..((...(((((....)))).))).).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((.(.......))).)))).....)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((.((...((.(((....))).))....(......)..)).)).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(.(..((...(((....)))...))....).).....)))))))......(.....((((((........)))))).....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((.....(((((..((((..((....)).)))).)))))....)))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... E. coli 70S-fMetVal-tRNAVal-tRNAfMet complex in classic post-translocation state (post1); 16S ribosomal RNA 4v75 A1 76 12.0 RF00005 URS00003179F7_83333 24186064 0030533 0006412 83333 ggguganuagcucagcugggagagcaccucccunacnaggaggggnucggcggnucgaucccgucaucacccacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).(((((.......))))).....(((((..]....)))))))))))).... E. coli 70S-fMetVal-tRNAVal-tRNAfMet complex in classic post-translocation state (post1); fMet-Val-tRNA-Val 4v75 A2 15 12.0 URS000080E284_32630 24186064 32630 acuaugguuuuuauu ............... ............... E. coli 70S-fMetVal-tRNAVal-tRNAfMet complex in classic post-translocation state (post1); 5'-R(*AP*CP*UP*AP*UP*GP*GP*UP*UP*UP*UP*UP*AP*UP*U)-3' 4v75 A3 77 12.0 RF00005 URS000041AF00_83333 24186064 0030533 0006412 83333 cgcggggnggagcagccuggnagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca ...<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>....... ...((((..(.((......[..)).).(((((.......))))).....(((((..]....)))))))))....... E. coli 70S-fMetVal-tRNAVal-tRNAfMet complex in classic post-translocation state (post1); tRNA-fMet 4v75 BA 2903 12.0 RF02540,RF02541 URS000080E25C_83333 24186064 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[.<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<......>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>....<<<<<.....<<....>>......>>>>>...........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..))).......].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<...<<<<<<....>>>>>>...>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<....<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<<.....>>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>....>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<.(......<<<<<<...........<<..<<<<<..<<........<<<<<.<<<..<<<.........>>>..>>>........<<<......>>>..>>>>>....>>..>>>>>.>>............)......>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<<.....<<<<<<<<....>>>>>>>>..>>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><...<<<<...<<<.<<<<<<<<.<<.....>>>>>>>>>>...>>>...>>>>....><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<<..............<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>..<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>.>......>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>...>>.>>>>>>>....>>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<<<<<..<<<........<.<<<<....>>>>.>.....>>>............>>>>>..>.>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<.......>>>>.....>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<...<<<<<<...............>>>>>>..<<<<<....<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>..>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<<...>>>>>><....<<..<<<<.........>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.)))....(((((((...(((]]]..].))).......)))))).).)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...).)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).(((((((.(..(((((((((.....(((...((..((((...(((((((.....))))).))...))))..))..)).).....)))))).)))...))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...(((..[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]...)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((..((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((((((((((...((((....((((..(((..(((((((((((....{{{...))))))((..((((...(((.((((((((.((.....))))))))))...)))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(....).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((...((.........))...((((.((.....(((....))).......)).))))..((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((((.(.........((.((..((........((.((((....)))).)).....))............)).))).)))).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][...[))....)))))))...((((..((((..{.))))..)))).(((....))).))]...].....(((((((.((..]]]]..))))))))).....)}......))))..)))))).......((((.(.((((((...((.......))...))))))...)))).)........(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((...))))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). E. coli 70S-fMetVal-tRNAVal-tRNAfMet complex in classic post-translocation state (post1); 23S ribosomal RNA 4v75 BB 117 12.0 RF00001 URS0000366A67_83333 24186064 0003735 0005840 83333 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggc <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>> (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))) E. coli 70S-fMetVal-tRNAVal-tRNAfMet complex in classic post-translocation state (post1); 5S ribosomal RNA 4v76 AA 1530 17.0 RF00177,RF01959,RF01960 URS000080E246_83333 24186064 0003735 0005840 83333 ugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggauca ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<<....>>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<<....>>>>>>......>>.>.....<<<....>>>....<<<<<<..<<<..>>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<.......<<<....>>>......>>>>..<<.<<<<<......<.<<<<<<..........>>.>>>>.>........>>>>>....>>.<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<.....<<<<<<<...<<<......>>>......>>>>>>>............<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<.......>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<..<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>.....<<<<<<.........>>>>>>.......>>...>>>>>>>.>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<...<<....>>..>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>...... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((((((((..)))))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..(((.......((((....))))......)))...(.(((((...(....((((...............)))).....)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].]((((..(((((((.((.((((((..((((((((((......((........))..........(((((((..(...((((.((..(((((((....)))))))...((....))..)).)).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((.(...((..(((.....)))))....).)))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(.(..((...(((....)))...))....).).....)))))))......(.....((((((........)))))).....)..)..))))))....(((((((.........)))))))......))...))))))).)).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... E. coli 70S-fMetVal-tRNAVal-tRNAfMet complex in intermediate post-translocation state (post2a); 16S ribosomal RNA 4v76 A1 76 17.0 RF00005 URS00003179F7_83333 24186064 0030533 0006412 83333 ggguganuagcucagcugggagagcaccucccunacnaggaggggnucggcggnucgaucccgucaucacccacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).(((((.......))))).....(((((..]....)))))))))))).... E. coli 70S-fMetVal-tRNAVal-tRNAfMet complex in intermediate post-translocation state (post2a); fMet-Val-tRNA-Val 4v76 A2 15 17.0 URS000080E284_32630 24186064 32630 acuaugguuuuuauu ............... ............... E. coli 70S-fMetVal-tRNAVal-tRNAfMet complex in intermediate post-translocation state (post2a); 5'-R(*AP*CP*UP*AP*UP*GP*GP*UP*UP*UP*UP*UP*AP*UP*U)-3' 4v76 A3 77 17.0 RF00005 URS000041AF00_83333 24186064 0030533 0006412 83333 cgcggggnggagcagccuggnagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ...((((..((((......[..)))).(.(((.......))).).....(((((..]....)))))))))....... E. coli 70S-fMetVal-tRNAVal-tRNAfMet complex in intermediate post-translocation state (post2a); tRNA-fMet 4v76 BA 2903 17.0 RF02540,RF02541 URS000080E25C_83333 24186064 0003735 0005840 83333 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<<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[[.(((.>>>.....<<<<<<<..<<<)))].].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>...>.>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<.....<<<<<....>>>>>.<<<<<<<....<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>>.>>....>>>>>>.>...<<<<<<<<<........>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<<..<<<.........>>>..>>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>.....>>>>><<<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>.>>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<..<.<..<<<<.<...<<.....>>..>>>>>....((<<<.<<<...<<....<<<....>>>....>>...>>>...<<<<........>>>>.))<<<<<<<<<<<<<..<<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>>...<<<<<....>>>>>....>>>>>...>>>...>>>>.........>>>>>..>>....>>>>>>>>>>>.>>>..>>.....<<......>>.>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>..<<<<.<<<..<<<<<<<..<<<<...<...<<<<<..<<....>>...>>>>>.>.....>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>...>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<.......(...<<<<<..<<........<<<<<<<....>>>>>>>.....>>..........).>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<.<..<.<<<<<<...<<.......>>...>>>>>>...>.>..>.......<.<<<...<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>.......>>>..>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<....<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>..>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<<<...>>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>.>.>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((.(.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((.........))))))))......(((((..[[[[)))))...))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((.(......).)))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((.(...((((((......))))))...)[.))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..(((((.....(((((....)))))..((((((((..(((((((((.....(((...(((.((((...(((((((.....))))).))...)))).)))..)).).....)))))).))).).))))))).....((((((((..........))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....))))))))).....)))))(((((((...(((......((((((((....))))))))...)))..))))).)).....))))))(......((.....((((((.......))))))((((....((((..((..(((((.(...((.....))..)))))....[[(((..((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((((((((((...((((....((((..(((..(((((((((((....{{{...))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))...(((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((..(((.({.....[..((.((..((........((.((((...})))).)).....))..........].)).))).)))..)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))(.((...(((((((.(.(((((.........)))))...).((.[..[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]..]......((((((.((..]]]]..))))))))......)}......))))..)))))).......(((..(.((((((...((.......))...))))))...).)).).......(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))....))..)))))))))).[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((...))))))(....(...(((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))......)..).))))))))). E. coli 70S-fMetVal-tRNAVal-tRNAfMet complex in intermediate post-translocation state (post2a); 23S ribosomal RNA 4v76 BB 117 17.0 RF00001 URS0000366A67_83333 24186064 0003735 0005840 83333 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggc <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>> (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))) E. coli 70S-fMetVal-tRNAVal-tRNAfMet complex in intermediate post-translocation state (post2a); 5S ribosomal RNA 4v77 AA 1530 17.0 RF00177,RF01959,RF01960 URS000080E246_83333 24186064 0003735 0005840 83333 ugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggauca ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<<....>>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<...<....>.>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.......<.<<<....<<<<....>>>>..>>>>.>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<........<<<<<<.<.......>.>>>>>>..........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<.......<<<....>>>.....>>>..)))).]<<<<<.<<<<<<<..<..<<<<<..<<<<<<...<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<..<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>.........>>>.........>>>...>>>>>>>>>...>>>>>>>...>....>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>.....<<<<<<<.........>>>>>>>......>....>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>.>>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>...... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((((((((..)))))))).)))))..)))))......(((......(.(((.(..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).).))).)(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((.(.......).)))))).....)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((.(((......((........))..........(((((((..(...(((((((..(((((((....)))))))...((....))..))))).))).((.((....((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(....(((.....))).......)..)))).....).).)))...))..))))....)))))))...)).).)))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((.....(((((..((((..((....)).)))).)))))....)))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}..... E. coli 70S-fMetVal-tRNAVal-tRNAfMet complex in intermediate post-translocation state (post2b); 16S ribosomal RNA 4v77 A1 76 17.0 RF00005 URS00003179F7_83333 24186064 0030533 0006412 83333 ggguganuagcucagcugggagagcaccucccunacnaggaggggnucggcggnucgaucccgucaucacccacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((........)))).(((((.......))))).....(((((.......)))))))))))).... E. coli 70S-fMetVal-tRNAVal-tRNAfMet complex in intermediate post-translocation state (post2b); fMet-Val-tRNA-Val 4v77 A2 15 17.0 URS000080E284_32630 24186064 32630 acuaugguuuuuauu ............... ............... E. coli 70S-fMetVal-tRNAVal-tRNAfMet complex in intermediate post-translocation state (post2b); 5'-R(*AP*CP*UP*AP*UP*GP*GP*UP*UP*UP*UP*UP*AP*UP*U)-3' 4v77 A3 77 17.0 RF00005 URS000041AF00_83333 24186064 0030533 0006412 83333 cgcggggnggagcagccuggnagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca ..<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>...... ...((((..(.((......[..)).).(((((.......))))).....(((((..]....)))))))))....... E. coli 70S-fMetVal-tRNAVal-tRNAfMet complex in intermediate post-translocation state (post2b); tRNA-fMet 4v77 BA 2903 17.0 RF02540,RF02541 URS000080E25C_83333 24186064 0003735 0005840 83333 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<<<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<.))).....>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<........>>>><<.......((.....>>))....>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>...>.>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<....<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>...>>.>.....>>>>>>>.>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<..<...<<<<.......>>>>...>.........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<..<<<<<....<<<<..<<<..<<<<<<<<<<<....[[....>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>>...<<<<......>>>>....>>>>>...>>>...>>>>.........>>>>>..>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<....<<<.....>>>....>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<<.<<....>>..>>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<...<<<<..<<<<..<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<..<<........<<<<<<<....>>>>>>>.....>>............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<.......>>>>>>>>....>>>>>.>>>...>>>>..<<<<.....>>>><<<<<<...........>>>>>>.......<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>...))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>....>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<.<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>..>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<...<<<<<<<<<<<.]].>>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. 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E. coli 70S-fMetVal-tRNAVal-tRNAfMet complex in intermediate post-translocation state (post2b); 23S ribosomal RNA 4v77 BB 117 17.0 RF00001 URS0000366A67_83333 24186064 0003735 0005840 83333 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggc <<<<<<<<......<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>....>>>>>>>> (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))) E. coli 70S-fMetVal-tRNAVal-tRNAfMet complex in intermediate post-translocation state (post2b); 5S ribosomal RNA 4v78 AA 1530 20.0 RF00177,RF01959,RF01960 URS000080E246_83333 24186064 0003735 0005840 83333 ugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggauca ....<<<<....((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<..........>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<<....>>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<...<<<<<<.........>>>>>>.>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<.......<<<....>>>......>>>>...<.<<<<<........<<<<<<.<.......>.>>>>>>..........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<....<.<<<<<<.....>>>>>>.>..>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<.....>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..))))..<<<<<.<<<<<<<.<....<<<<...<<<<<<<<.......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<<..<<<.....>>>>>.....>>>>>>.....<<<<<.....>>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>....>.>>>>>>>......<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>......<<<<<<<.........>>>>>>>.......>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<...<<....>>..>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>...... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((((.((....)).)))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..(((.......((((....))))......)))...(.(((((...(....((((.(.(.......)..))))).....)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......(((.((.....)).)))....)))))))))..))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].]((((..(((((((..(..(((((..((((((((((......((........))..........(((((((..(....((((((..(((((((....)))))))...((....))..))))).).).((.((....((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...))..))))....)))))))...)).)))))))).(...(((((((.....(.(..((...(((....)))...))....).).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......)....))))))).)).))..(.(..((.(.((((.(((..((((((.(((((....((((((.((((..((....)).))))))))))...))))).))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... E. coli 70S-fMetVal-tRNAVal-tRNAfMet complex in intermediate post-translocation state (post3a); 16S ribosomal RNA 4v78 A1 76 20.0 RF00005 URS00003179F7_83333 24186064 0030533 0006412 83333 ggguganuagcucagcugggagagcaccucccunacnaggaggggnucggcggnucgaucccgucaucacccacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).(((((.......))))).....(((((..]....)))))))))))).... E. coli 70S-fMetVal-tRNAVal-tRNAfMet complex in intermediate post-translocation state (post3a); fMet-Val-tRNA-Val 4v78 A2 15 20.0 URS000080E284_32630 24186064 32630 acuaugguuuuuauu ............... ............... E. coli 70S-fMetVal-tRNAVal-tRNAfMet complex in intermediate post-translocation state (post3a); 5'-R(*AP*CP*UP*AP*UP*GP*GP*UP*UP*UP*UP*UP*AP*UP*U)-3' 4v78 BA 2903 20.0 RF02540,RF02541 URS000080E25C_83333 24186064 0003735 0005840 83333 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<.<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<......<<<<<<<<<<<<<.<<<...<<<<........>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<.>>>>>..>>>......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>...<.<......>>......>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>...>.>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<<.....>>>>>.>>...>>>>.>>>..>>.>.....>>>>>>>.>>...>>>>>>>.>...<<<<<<<<<........>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<<..<<<.........>>>..>>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><.<<<<<...<<.<.....<<<<<<<<....>>>>>>>>..>.>>..>>>>>..>.....>>>>>>.<.....<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>>...<<<<<....>>>>>....>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<<..............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>..<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>...>>.>>>>>>>....>>>.>>>>>>>>.>>>>>>...>.......<<<<<........>>>>>..<<<<<<<<.<<<.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<..<<........<<.<<<<....>>>>.>>.....>>............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((...>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<.<<<.<<<<<<..<<<<<<<<........>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>..>....<<<<<<<....>>>.>>>>....]]..>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<....<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>..>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<<<...>>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>.. 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E. coli 70S-fMetVal-tRNAVal-tRNAfMet complex in intermediate post-translocation state (post3a); 23S ribosomal RNA 4v78 BB 117 20.0 RF00001 URS0000366A67_83333 24186064 0003735 0005840 83333 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggc <<<<<<<<......<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.....<.<<<<<<<<...>>>>>>>>...>...>>....>>>>>>>> (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))) E. coli 70S-fMetVal-tRNAVal-tRNAfMet complex in intermediate post-translocation state (post3a); 5S ribosomal RNA 4v79 AA 1530 15.0 RF00177,RF01959,RF01960 URS000080E246_83333 24186064 0003735 0005840 83333 ugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggauca ....<<<<...[((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<<....>>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<<....>>>>>>......>>.>......<<....>>.....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<..[.>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<.......<<<....>>>......>>>>...<.<<<<<.......<.<<<<<.<.......>.>>>>>>..........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>.......]..<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<....<<<......>>>.......>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<..<<<<<<<....<<<<<<..<<<<<<<<<<.......<........>...........<<<<<<<.......<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>..<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<<..<<<.....>>>>>.....>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>.........<.<<<<<<<........>>>>>>>>.........>>>>>>....<<<<<<<.........>>>>>>>...........>>>>>>>.>>.>>.......<<.<.<<<<.<<<..<<<<<<<.<<<.....<<<<<<.<<<...<<....>>..>>>>>>>>>....>>>.>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>...... ....((((...[[[[..)))).((((.(((((..((((((.((....(((.(((..(((..((.((..(((((((((((..)))))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).)......((....)).....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)..))))))..((((......((((....)))).....))))..((.(((((...(...(.(((((.(.......).)))))..)...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...((..(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((....((((((.....(((((((....(........).......)))))))............((....)).))))))...))).)))))..).))...))))....((((((...((...((((.........))))...))))))))..........((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].]((((..(((((((..(..(((((..((((.(((((.......(........)...........((((.((..(...(.(((((..(((((((....)))))))...((....))..)))))..)).((.(((...((((.(.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).)..))...)).)))))....)).))))...)).))).)))).(...(((((((.....(.(..((...(((....)))...))....).).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......)....))))))).)).))..(.(..((.(.((((.(((..(((((((.(((.....((((((.((((..((....)).))))))))))....))).)))))))..))).))))..).))...)..)..(((((((((....)))))))))...... E. coli 70S-fMetVal-tRNAVal-tRNAfMet complex in intermediate post-translocation state (post3b); 16S ribosomal RNA 4v79 A1 76 15.0 RF00005 URS00003179F7_83333 24186064 0030533 0006412 83333 ggguganuagcucagcugggagagcaccucccunacnaggaggggnucggcggnucgaucccgucaucacccacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).(((((.......))))).....(((((..]....)))))))))))).... E. coli 70S-fMetVal-tRNAVal-tRNAfMet complex in intermediate post-translocation state (post3b); fMet-Val-tRNA-Val 4v79 A2 15 15.0 URS000080E284_32630 24186064 32630 acuaugguuuuuauu ............... ............... E. coli 70S-fMetVal-tRNAVal-tRNAfMet complex in intermediate post-translocation state (post3b); 5'-R(*AP*CP*UP*AP*UP*GP*GP*UP*UP*UP*UP*UP*AP*UP*U)-3' 4v79 BA 2903 15.0 RF02540,RF02541 URS000080E25C_83333 24186064 0003735 0005840 83333 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<<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<.......>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>.......>>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>>.>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.......<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<<..<<<<.......>>>>..>>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>......>>>><<<<<<<<<....>>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>>.......<<.....<<<<<<.......>>>>>>.<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<..<<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>>...<<<<<....>>>>>....>>>>>...>>>...>>>>.........>>>>>..>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>...<<<<....<<<<<<<<.<<<..............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<.<..<<....>>...>.>>>........>>>>>>>>..>>>>>.<<<<<.......>>>>>.........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>....>>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<..<<........<<<<<<<....>>>>>>>.....>>............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<.........>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<..<<<<<<<...<<.......>>...>>>>>>>...>>>.>.......<<<<<...<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<.......>>>>.....>>>>.......>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<.)))..>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<<...>>>>>>.....<<.....<.........>.......<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. 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E. coli 70S-fMetVal-tRNAVal-tRNAfMet complex in intermediate post-translocation state (post3b); 23S ribosomal RNA 4v79 BB 117 15.0 RF00001 URS0000366A67_83333 24186064 0003735 0005840 83333 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggc <<<<<<<<<.....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>>.<<...<...<<<<<<<<...>>>>>>>>.....>.>>...>>>>>>>>> (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))) E. coli 70S-fMetVal-tRNAVal-tRNAfMet complex in intermediate post-translocation state (post3b); 5S ribosomal RNA 4v7a AA 1530 9.0 RF00177,RF01959,RF01960 URS000080E246_83333 24186064 0003735 0005840 83333 ugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggauca ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<..<<<..>>>..>>>.>>>.>..>>>>>......<<..<....<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>>>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<.......<<<....>>>......>>>>...<.<<<<<........<<<<<<.<.......>>>.>>>>..........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<.......<<<....>>>.....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<...<<<<<<<<........<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>......>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>......>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<...<<....>>..>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((((.(((..))).)))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((.(.........)))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))...(((......((((....)))).....)))....(.(((((...(....((((((.(.......))).)))).....)....)))))....)..(((((.[[...(((((.....((.]].)).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((..(((((((....)))))))...((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....))))))))..)).)))))))).(...(((((((.....(.(..((...(((....)))...))....).).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((.(..((....))..)))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... E. coli 70S-fMetVal-tRNAVal post-translocation complex (post4); 16S ribosomal RNA 4v7a A1 76 9.0 RF00005 URS00003179F7_83333 24186064 0030533 0006412 83333 ggguganuagcucagcugggagagcaccucccunacnaggaggggnucggcggnucgaucccgucaucacccacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).(((((.......))))).....(((((..]....)))))))))))).... E. coli 70S-fMetVal-tRNAVal post-translocation complex (post4); fMet-Val-tRNA-Val 4v7a A2 15 9.0 URS000080E284_32630 24186064 32630 acuaugguuuuuauu ............... ............... E. coli 70S-fMetVal-tRNAVal post-translocation complex (post4); 5'-R(*AP*CP*UP*AP*UP*GP*GP*UP*UP*UP*UP*UP*AP*UP*U)-3' 4v7a BA 2903 9.0 RF02540,RF02541 URS000080E25C_83333 24186064 0003735 0005840 83333 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<<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<......>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<......<<<<<<<<<<<<<.<<<...<<<<........>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>>.>>...............<<....>>....>>.........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<<<........>.>><<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<<..<<<<.......>>>>..>>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<<.....<<<<<<<<....>>>>>>>>..>>>>..>>>>>........>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<..<<...<<<<<....<<.....>>..>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....[[[...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>>...<<<<<....>>>>>....>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>.>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<<..............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<..<<....>>...>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>....>>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.<<..<<......<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<..<<............<<<....>>>.........>>............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>.(<<...<<<<<<<...<<<<<.........>>>>>.....<<)..(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>)))........<<<<<<.<<..))))..>>>>>>>>..............>>>>..>>>>>>.......<<<<..<<<<<<<...<<.......>>...>>>>>>>...>>>.>.......<<<<<.<<<<<<..<<<<<<<..........>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>...>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<....<<<...<<<<<<<<<<.]]]..>>>>>..>>>>>...>>>..>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<<...>>>>>>.........<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>.>.>>>>>.>>>............>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...((.]]]..]..)).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(.(((].[[[[))).)..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((...(((((((((.....(((...(((.((((...(((((((.....))))).))...)))).)))..)).).....)))))).)))...))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((......[..)))..))).....(...((......))]).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((.<..((((..((..(((((((...((.....)).))))))....[[(((..((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((((((((((...((((....((((..(((..(((((((((((....{{{...))))))((...(((...(((((((((((..((.....)).)))))))..))))..[)))....))(..(((((....)))))...))))))..>)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..((.........(((((..((....))...))))).........)))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.((..((......((((.((((((..(((((.(((.(((((.(((((((((((.((((.([.....{..((.((..((........(...(((...])))...).....))..........}.)).))).)))).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].]......((((((.((..]]]]..))))))))......)}......))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))....))...))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((...))))))(........(((((.......)))))....((((((((..((.....((((....))))....))...))))).))).........).))))))))). E. coli 70S-fMetVal-tRNAVal post-translocation complex (post4); 23S ribosomal RNA 4v7a BB 117 9.0 RF00001 URS0000366A67_83333 24186064 0003735 0005840 83333 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggc <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>> (((((((((.....((.(((((....(((((((...(.....)...))))..)))...)))))..)).((.......((((((((...)))))))).......))...))))))))) E. coli 70S-fMetVal-tRNAVal post-translocation complex (post4); 5S ribosomal RNA 4v7b AA 1533 6.8 RF00177,RF01959,RF01960 URS00000ABFE9_83333 24324168 0003735 0005840 83333 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggauca .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<..<<<......>>>..>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<.<.......>.>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).].<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<......>>..<<<<......>>>>..>>>>>>.....<<<..<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>.........>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>.....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .......((((.....[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((...................)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..(......))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(...(((((((..........).))))).)...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]...((....(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))...(......)..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((...((.....)).))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))....))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Visualization of two tRNAs trapped in transit during EF-G-mediated translocation; 16S ribosomal RNA 4v7b AV 77 6.8 RF00005 URS000080E012_83333 24324168 0030533 0006412 83333 cgcgggguggagcagccugguagcucgucgggcuuacaacccgaaggucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Visualization of two tRNAs trapped in transit during EF-G-mediated translocation; modified formyl-methionine specific initiator transfer RNA 4v7b AW 77 6.8 RF00005 URS0000093D11_83333 24324168 0030533 0006412 83333 ggcuacguagcucaguugguuagagcacaucacucauaaugauggggucacagguucgaaucccgucguagccacca <<<<<<<..<<<...........>>>.<<<<<.......>>>>>.....<<.<<.......>>.>>>>>>>>>.... (((((((..(((...........))).(((((.......)))))........((.......))...))))))).... Visualization of two tRNAs trapped in transit during EF-G-mediated translocation; formyl-methionine specific initiator transfer RNA 4v7b AX 19 6.8 24324168 83333 gguaaaaaugguaaaaaaa ................... ................... Visualization of two tRNAs trapped in transit during EF-G-mediated translocation; messenger RNA 4v7b BB 118 6.8 RF00001 URS0000049E57_83333 24324168 0003735 0005840 83333 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))). Visualization of two tRNAs trapped in transit during EF-G-mediated translocation; 5S ribosomal RNA 4v7b BA 2854 6.8 RF02540,RF02541 URS00004B0F34_83333 24324168 0003735 0005840 83333 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<<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<.....>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>.>......>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.......................................>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((((((.)))).))...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..((((......))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((((.(.............................................).))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Visualization of two tRNAs trapped in transit during EF-G-mediated translocation; 23S ribosomal RNA 4v7c AA 1538 7.6 RF00177,RF01959,RF01960 URS00000ABFE9_562 24324137 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccucc .......<<<<..[[((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<......<<<<.<<<<....>>>.>>>.>>.....>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<..<<....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<<..>>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<.<<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>...<.<<<<<......<<<<<<<<<<.......>>>>>>>>.>>.......>>>>>....>..<<<<<(((...<<<<<.....<..))).>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>.>..........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]]<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<........<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>....<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<....<<.....>>..>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>.....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>...>>>>>>>>>>>>..>>.>>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>........... .......((((.....[...)))).((((.(((((..(((((((((....(((.(((..(((..((.(.....(((.(..........).)).)...)..)))))......(((.......((((((..((...(((((((...((.....((((((....))))))......)).......(((....)))....((((((..........)))))).)))))))..)).)))))).(((....(((...(((((((.......))))))).)))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))))......(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((((.......)))))))).....)....)))))....)..((((([[[...(((((........]]].........))))))))))..)))))))))..........((([[.....((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))).)))))..))))...))))....(.((((...((...((((.........))))...)))))).)......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))).))).(((......((((....))))....)))....]...(((((.((((.((.((..(((((..((((((((((......((........))..........(((((((........(((((..(((.(((....))).)))....(....)...))))).....((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((.(...((..((.......))))....).)))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((.(((........))).)))....)..)..))))).....(((((((.........)))))))......))...)).))))))).))....(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...).....(((((((((....)))))))))}.......... Structure of the Ribosome with Elongation Factor G Trapped in the Pre-Translocation State (pre-translocation 70S*tRNA structure); 16S ribosomal RNA 4v7c AV 76 7.6 RF00005 URS00005AA258_83333 24324137 0030533 0006412 83333 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca .<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>..... ((.((((..((.(........).))..((((.......))))......((.((.......)).)))))).)).... Structure of the Ribosome with Elongation Factor G Trapped in the Pre-Translocation State (pre-translocation 70S*tRNA structure); tRNA 4v7c AW 76 7.6 RF00005 URS00005AA258_83333 24324137 0030533 0006412 83333 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).(((((.......))))).....((.((..]....)).))))))))).... Structure of the Ribosome with Elongation Factor G Trapped in the Pre-Translocation State (pre-translocation 70S*tRNA structure); tRNA 4v7c AX 18 7.6 24324137 aggagguaaaauucuuca .................. .................. Structure of the Ribosome with Elongation Factor G Trapped in the Pre-Translocation State (pre-translocation 70S*tRNA structure); mRNA 4v7c BA 2897 7.6 RF02540,RF02541 URS000080E25C_562 24324137 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagaccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucagucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((...<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>.........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.......<...<<<.<<<<...<<.<<<.......>>>..>>...>>>>.>>>..>........>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<...........<<...<<<<.......>>>>...>>........<<<......>>>........>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<..<<....>>..>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>...<<<<........>>>>.))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>>...<<<<<....>>>>>....>>>>>...>>>...>>>.>........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<..<<....>>...>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.((......<<<<.((<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<..<<<...........<<<<<...<<......<<<<<<<<....>>>>>>>>...>>.............>>>>>..>>>..>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<......>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>..........<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..))>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<.<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>..>....<<<<<<<....>>>.>>>>....))..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((......((..((((((((.((.(......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).)....((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))....(((...((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...)).....)....(((((((...[.......)))))))......(((((].{.{{)))))..)).......))..)))))).))...............((....))....))......(..((((.....))))............)......)))))))))).....(.((((..(((((......)))))..))))...(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...).)))...(((.(((((........))))))))..).))))))))).(.((.......))...)..))))))......).))..((((((....((((......)))).((((((((..((((((((((......((...(((.((((......(...........).......)))).)))..)).......)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[.....((((((.....(.....((..((((...((.............(..(((.........)))..).......(...((......)).).......))...)))).))...........]]].)...)))))).)))...)))))))((((..............))))....))))))...((((...(((......((((((((....))))))))...)))..)))).........))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((...(((...(((....)))...)))...)))..(((((........)))))]]((((((((((.((...((((....((((..(((..(((((.((((((...[[[.).))))).((..(((.....((.((((((((.((.....))))))))))...))...{.)))...))(..(((((....)))))...))))))...)))...))))(..).....))))...)).....)))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....(((((((..((..(............(((((....(.[..).....)))))((((((.....(((...((((....}))))...)))...))))))(...).......(((((((((...((.........))...(((((((.....(((....))).......))))))).]((((.(((..(((((((...((........(((((..((....))...)))))........)).)))))..)))))..(((.........)))..........((..........(((((.......)))))..)..)....))))...)).)))))))....)))..))))))).)))))).....)).[..(((((......].)))))..((((((((.(((.((......((((.(((((.(.(((((.(((.(((((.(((((((((((..(((...........((((....((..........((.(....).)).......))..............))))..)))..)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))(.((...(((((((...(((((.........))))).....((.....[))....)))))))...((((..((((....))))..)))).(((....))).))].........(((((((.((..}}.}..))))))))).....).......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....))..))))))))))){...(((((((...((((..(((((((.....(....)....))))))).(((((...(.((...(((((((((((]]].))))))..)))))...)).).)))))...(((....(.((.............)).)....))).))))..}....)))))))..(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..)..)))))))). Structure of the Ribosome with Elongation Factor G Trapped in the Pre-Translocation State (pre-translocation 70S*tRNA structure); 23S ribosomal RNA 4v7c BB 119 7.6 RF00001 URS000080E133_562 24324137 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<........<<<<<<<...>>>>>>>........>>...>>>>>>>>>> ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))) Structure of the Ribosome with Elongation Factor G Trapped in the Pre-Translocation State (pre-translocation 70S*tRNA structure); 5S ribosomal RNA 4v7d AA 2897 7.6 RF02540,RF02541 URS000080E25C_562 24324137 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagaccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucagucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.......<...<<<.<<<<...<<.<<<.......>>>..>>...>>>>.>>>..>........>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<...........<<...<<<<.......>>>>...>>........<<<......>>>........>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<..<<....>>..>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>...<<<<........>>>>.))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>>...<<<<<....>>>>>....>>>>>...>>>...>>>.>........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<<.<<....>>..>>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.((......<<<<.((<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<...<<......<<<<<<<<....>>>>>>>>...>>.............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...((.>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>.)).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..))>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....))..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((......((..(((((((((((.(......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).)....((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.(.((......(((((((((((((.(((...(((((......)))))[[......(((.....]])))...)))...)))))))))))))...)).)...)....(((((((...[.......)))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)......)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...).)))...(((.(((((........))))))))..).))))))))).(.((.......))...)..))))))......).))..((((((....((((......)))).((((((((..((((((((((.....(((...(((.((((...((.(...........)..))...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..((.............(..(((.........)))..).......(...((......)).).......))..))))).))...........]]].)...))))))))))...)))))))((((..............))))....))))))(..((((...(((......((((((((....))))))))...)))..))))...).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((...(((...(((....)))...)))...)))..(((((........)))))]]((((((((((.((...((((....((((..(((..(((((.((((((...{{{.).))))).((..(((.....(((((((((((.((.....))))))))))..)))...{.)))...))(..(((((....)))))...))))))...)))...))))(..).....))))...)).....)))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....(((((((..((..(............(((((....(.[..).....)))))((((((.....(((...((((....}))))...)))...))))))(...).......(((((((((...((.........))...(((((((.....(((....))).......))))))).]((((.(((..(((((((...((........(((((..((....))...)))))........)).)))))..)))))..(((.........)))..........((..........(((((.......)))))..)..)....))))...)).)))))))....)))..))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.(((((...(((((.(((.(((((.(((((((((((..(((.(.........((((....((..........((.(....).)).......))..............))))).)))..)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))(.((...(((((((...(((((.........))))).....((...[[[))....)))))))...((((..((((....))))..)))).(((....))).))]]].......(((((((.((..]]]]..))))))))).....)........)))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...(.((...(((((((((((}}}.))))))..)))))...)).).)))))...(((....(.((.............)).)....))).))))..]....)))))))..(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..)..)))))))). Structure of the Ribosome with Elongation Factor G Trapped in the Pre-Translocation State (pre-translocation 70S*tRNA*EF-G structure); 23S ribosomal RNA 4v7d AB 119 7.6 RF00001 URS000080E133_562 24324137 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<........<<<<<<<...>>>>>>>........>>...>>>>>>>>>> ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))) Structure of the Ribosome with Elongation Factor G Trapped in the Pre-Translocation State (pre-translocation 70S*tRNA*EF-G structure); 5S ribosomal RNA 4v7d BA 1538 7.6 RF00177,RF01959,RF01960 URS00000ABFE9_562 24324137 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccucc .......<<<<..[[((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<......<<<<.<<<<....>>>.>>>.>>.....>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<..<<....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<<..>>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<.<<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>...<.<<<<<......<<<<<<<<<<.......>>>>>>>>.>>.......>>>>>....>..<<<<<(((...<<<<<.....<..))).>.......>>>>>>>>>>..>>>>>>>>>...........<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>.>..........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>..<<<.......<<<....>>>.....>>>..)))).]]<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<........<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>....<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<....<<.....>>..>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>.....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>...>>>>>>>>>>>>..>>.>>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>........... .......((((.....[...)))).((((.(((((..(((((((((....(((.(((..(((..((.(.....(((.(..........).)).)...)..)))))......(((.......((((((..((...(((((((...((.....((((((....))))))......)).......(((....)))....((((((..........)))))).)))))))..)).)))))).(((....(((...(((((((.......))))))).)))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....(.((((((.......)))))).).....)....)))))....)..((((([[[...(((((.....(..]]].).......))))))))))..)))))))))...........(([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))..(((........((....))......)))....]...(((((.((((.((.((..(((((..((((((((((......((........))..........(((((((........(((((..(((.(((....))).)))....(....)...))))).....((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((.(...((..(((.....)))))....).)))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((.(((........))).)))....)..)..))))).....(((((((.........)))))))......))...)).))))))).))....(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...).....(((((((((....)))))))))}.......... Structure of the Ribosome with Elongation Factor G Trapped in the Pre-Translocation State (pre-translocation 70S*tRNA*EF-G structure); 16S ribosomal RNA 4v7d BV 76 7.6 RF00005 URS00005AA258_83333 24324137 0030533 0006412 83333 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca .<<<<<<..<<<<........>>>>.<<.<<<.....>>.>>>.....<<<<<.......>>>>>>>>>>>..... ...((((..((.(........).)).((..(.......)..)).....((.((.......)).))))))....... Structure of the Ribosome with Elongation Factor G Trapped in the Pre-Translocation State (pre-translocation 70S*tRNA*EF-G structure); tRNA 4v7d BW 76 7.6 RF00005 URS00005AA258_83333 24324137 0030533 0006412 83333 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((........)))).(((((.......))))).....((.((.......)).))))))))).... Structure of the Ribosome with Elongation Factor G Trapped in the Pre-Translocation State (pre-translocation 70S*tRNA*EF-G structure); tRNA 4v7d BX 18 7.6 24324137 aggagguaaaauucuuca .................. .................. Structure of the Ribosome with Elongation Factor G Trapped in the Pre-Translocation State (pre-translocation 70S*tRNA*EF-G structure); mRNA 4v7e Ad 1762 5.5 RF01960,RF01959,RF00177 URS000080E2C6_4565 24499919,20980660,20974910 0003735 0005840 4565 uaccugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugugcaaguaugaaccaauuugaacugugaaacugcgaauggcucauuaaaucaguuauaguuuguuugaugguacgugcuacucggauaaccguaguaauucuagagcuaauacgugcaacaaaccccgacuucugggaggggcgcauuuauuagauaaaaggcugacgcgggcucugcucgcugauccgaugauucaugauaacucgacggaucgcacggccuucgugccggcgacgcaucauucaaauuucugcccuaucaacuuucgaugguaggauaggggccuaccaugguggugacgggugacggagaauuaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccugacacggggagguagugacaauaaauaacaauaccgggcgcauuagugucugguaauuggaaugaguacaaucuaaaucccuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuuaaguuguugcaguuaaaaagcucguaguuggaccuugggccggccggcaucgcgcuccuagccuuaauuggccgggucguguuuccggcaucguuacuuugaagaaauuagagugcucaaagcaagccaucgcucuggauacauuagcaugggauaacaucauaggauuccgguccuauuguguuggccuucgggaucggaguaaugauuaauagggacagucgggggcauucguauuucauagucagaggugaaauucuuggauuuaugaaagacgaacaacugcgaaagcauuugccaaggauguuuucauuaaucaagaacgaaaguugggggcucgaagacgaucagauaccguccuagucucaaccauaaacgaugccgaccagggaucggcggauguugcuuauaggacuccgccggcaccuuaugagaaaucaaagucuuuggguuccggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggcguggagccugcgcuuaauuugacucaacacggggaaacuuaccagguccagacauagcaaggauugacagacugagagcucuuucuugauucuaugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccguuaacgaacgagaccucagccugcuaacuagcuaugcggagccaucccuccgcagcuagcuucuuagagggacuauggccguuuaggccacggaaguuugaggcaauaacaggucugucaugcccuuagauguucugggccgcacgcgcgcuacacugauguauucaacgaguauauagccuuggccgacaggcccggguaaucuugggaaauuucaucgugauggggauagaucauugcaauuguuggucuucaacgaggaaugccuaguaagcgcgagucaucagcucgcguugacuacgucccugcccuuuguacacaccgcccgucgcuccuaccgauugaaugguccggugaaguguucggaucgcggcgacgggggcgguucgccgcccccgacgucgcgagaaguccauugaaccuuaucauuuagaggaagcagaagucguaacaagguuuccguaggugaaccugcggaaggaucauug ...<<<<....[[[[.>>>>.<<<.<<<<<<...<.<<..<......<<<.<<<..<<...<<.....<<...........>>....>>>>......<<........<<<..<<..<<....<<<<<............<<.....<..<<<.....>>>..>......>>..........<<<............>>>.<...<..<<<.....[[[.(((((<<<.........>>>...............>>>.>......>........<<<<......>>>.>.....>>>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>...<<....>>.....>>>>>>.........<<<....<<<.....>>>..>>>..>>...>.>.....<<.<<.<<..............>>.>>..>>......<<.................>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>>>>..........<.<{{.....<.<<...<<<.<.....<.<<<<..>>>>.>...<..............<<<.....>>>............><<<<<<.<<.......<<...<.......>...<.......>.....>>......>>.>>..>>>>.........<<<<<<<<<<.....))))).]]].>>>>>>>>>>.......>....<<<<<<.<<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<.......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<......<<<<......>>>>........>>..>>>>.>>.....<<<<<.....>>>>>........>>>>>....>>>.>>>.....>>>>>>>.....>.>>>>>......>>>>.>>>.....<<<<.<.......<<.......<<<.<<<<....>>>>.>>>....>>........>.>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<.<<.<<....<<<<<<<..<<<..<<<<..<...<<...<<<.<<<<<<<<<....>>>>>>>>>.>>>...>>...>..>>>>..>>>..>>>>>>>...>>.>>.>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..)))).(((.((((((...(.(...((.....(((.(((..(.....(.....((...........))....)[.)......(((.......(((......((....((((....................(....(.....)....)..................(((..(......)..))).(.(.(.(..(......{{....{.(((.........)))...............)..).).)...).(......((((......))).)...)..))))...))....))).(((.....((....((((((((.......)))))))))).......)))...(((..(((....))).....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)....).).....((....(((............))).....))........(..............)............(.((([[......((((.....((..]])).......)))).))).)..)))))))))...[......(.([[.....(.((...(((..(....(.((((())))).)...................(.......)..............((((((.((.......((..((.......))..(.......).....))......)).))..)))).......((...(.((.((......}....}}..)).)).)...)..)..)....(((..((.((...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)).))...))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..((((((((.(((........)))))))))))..)))...((..]]))...))...].))).).).(((......((((....))))....)))...]]].](((((.(((((....((..(((((..(((.(((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..((...(...(((......)))....)....))..)))).))..(..(((((.....))))).....)..)))))....))).))).....).))))).....).)))))...)..)))).))).(...((((.(.......((.......(((.((((....)))).)))....))........).))))......(....(((.((..........)).)))....)..)..)))))......(((((((.......))))))).......)).....)))))))).))..(.(..((.(....((.((....(((((((..(((..((((..(...((...(((.(((((((((....))))))))).)))...))...)..))))..)))..)))))))...)).)).....).))...)..)..(((((((((....)))))))))}........ Model of the small subunit RNA based on a 5.5 A cryo-EM map of Triticum aestivum translating 80S ribosome; 18S ribosomal RNA 4v7e Ae 75 5.5 RF00005 URS00005AD0B9_4565 24499919,20980660,20974910 0030533 0006412 4565 uccgugauaguuuaauggucagaaugggcgcuugucgcgugccagaucgggguucaauuccccgucgcggagcca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>....<<<<<.......>>>>>>>>>>>>.... (((((((..((((........)))).(((.(.......).)))....(((((.......)))))))))))).... Model of the small subunit RNA based on a 5.5 A cryo-EM map of Triticum aestivum translating 80S ribosome; P-site tRNA 4v7e Af 11 5.5 URS000080E0BA_4565 24499919,20980660,20974910 4565 aaaagacuuca ........... ........... Model of the small subunit RNA based on a 5.5 A cryo-EM map of Triticum aestivum translating 80S ribosome; 5'-R(*AP*AP*AP*AP*GP*AP*CP*UP*UP*CP*A)-3' 4v7e Aa 3391 5.5 RF02540,RF02543 URS000080E1E6_4565 24499919,20980660,20974910 0003735 0005840 4565 gcgcgaccccaggucaggcgggacuaccgcugaguuuaagcauauaaauaagcggaggagaagaaacuuacaaggauuccccuaguaacggcgagcgaaccgggagcagcccagcuugagaaucgggcggcugugccguccgaauuguagucuggagaggcguccucagcgacggaccgggcccaaguccccuggaaaggggcgccugggagggugagagccccguccggcccggacccugucgccccacgaggcgccgucaacgagucggguuguuugggaaugcagcccaaaucgggcgguagacuccguccaaggcuaaauacaggcgagagaccgauagcgaacaaguaccgcgagggaaagaugaaaaggacuuugaaaagagagucaaagagugcuugaaauugccgggagggaagcggaugggggccggcgaugcgccccggccguaugcggaacggcucuugcugguccgccgcucggcucggggcguggacuguugucggccgcgccggcggccaaagcccgggggcuccgcgcccccggcagccgucgucggcacggccgguacccgcgcgccgaaaggcgugccccucggggcacugcgcugcaacgcccugcgggcuccccauccgacccgucuugaaacacggaccaaggagucugacaugcgugcgagucgacggguucugaaaccugggaugcgcaaggaagcugacgagcgggaggcccucacgggccgcaccgcuggccgacccugaucuucugugaaggguucgaguuggagcacgccugucgggacccgaaagauggugaacuaugccugagcggggcgaagccagaggaaacucugguggaggcucgaagcgauacugacgugcaaaucguucgucugacuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggagcccauuacgaguucuaucagguaaagccaaugauuagaggcauuggggacgcaacguccucgaccuauucucaaacuuuaaauagguaggauggcgcggcugcuucggugagccgugccauggaaucgggugcuccaagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccggaagccggguuacggugcccaacugcgcgcuaaccuagaacccacaaaggguguuggucgauuaagacagcaggacgguggucauggaagucgaaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagccccgaaaauggauggcgcugaagcgcgcgacccacacccggccaucugggcgagugccaugccccgaugaguaggagggcgcggcggccgaugcaaaacccggggcgcgagcccgggcggagcggccgucggugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaaggccgaagaggagaaagguuccaugugaacggcacuugcacauggguaagccgauccuaagggaagggguaaccccggcagauagcgcgaucacgcgcauccccgaaagggaaucggguuaagauuucccgagccgggauguggcgguugacggcgacguuaggaaguccggagacgccggcgggggccucgggaagaguuaucuuuucugcuuaacggccugccaacccuggaaacgguucagccggagguaggguccaguggccggaagagcacacgucgcgcgguguccggugcgcccccggcggcccaugaaaauccggaggaccgaguaccguucacgcccggucguacucauaaccgcaucaggucuccaaggugaacagccucuggccaauggaacaauguaggcaagggaagucggcaaaacggauccguaacuucgggaaaaggauuggcucugaggacugggcucgggggucccggccccgaacccgucggcugucggcggauugcucgagcugcucacgcggcgagagcgggucgccgcgugccggccgggggacggaccgggaaucgccccuucgggggcuuuccccgagcaugaaacagucgacucagaacugguacggacaaggggaauccgacuguuuaauuaaaacaaagcauugcgaugguccucgcggaugcugacgcaaugugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaaugaauggauuaacgagauucccacugucccugucuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuaguccgacuuugugaaaugacuugagagguguaggauaagugggagcccucacgggcgcaagugaaauaccacuacuuuuaacguuauuuuacuuauuccgugggucggaagcggggcaugccccuccuuuuggcuccaaggcccggucuuaccgggccgauccgggcggaagacauugucagguggggaguuuggcuggggcggccaaucuguuaaaagauaacgcagguguccuaagaugagcucaacgagaacagaaaucucguguggaacaaaaggguaaaagcucguuugauucugauuuccaguacgaauacgaaccgugaaagcguggccuaucgauccuuuagacuucggaguuugaagcuagaggugucagaaaaguuaccacagggauuacuggcuuguggcagccaagcguucauagcgacguugcuuuuugauccuucgaugucggcucuuccuaucauugcgaagcagaauucaccaaguguuggauuguucacccaccaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugacagugucgcgauaguaauucaaccuaguacgagaggaaccguugauucacacaauuggucaucgcgcuugguugaaaagccaguggcgcgaagcuaccgugugccggauuaugacugaacgccucuaagucagaauccaagcuagcaugcgacgccugcgcccgccgcccgccccgacccacguuaggggcgcuugcgcccccaagggcccgugccauuggcuaagccgguccggccgaagugccgcggucggccgccucgaagcucccuucccaacgggcggugggcugaauccuuugcagacgacuuaaauacgcgacggggcauuguaaguggcagaguggccuugcugccacgauccacugagauccaguccccgcgucgcacggauucgu ..........................<<<<<.....<......>......>>>>>...........<<....>>..<<<<<.......<.....>......>>>>>..<<<...........<<<<<<<<<...>>>>>>>>>.............<<<<<<.<<<<.<<<<<<<.<<<<<<<.....<<<<......>>>>.((......<<<.....))>>>....>>>>>>>...>>>>>>>.....>>>>>>>>.>>........<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>....................................<<<<<<<<<<.<<...<<<<<<<<<<<<..<<<<<<.<<<<....>>>>.>>>>.>>..>>>>.>>>>>>>>....<<<<<<<<<<<<.<<<<<<<<.......<<<<<<<<.....>>>>>>>>......>>>>>>>>.>>>>>>>.....<<<<<<<....>>><<<<<<....>>>>>>.>>>>..>>>>>....>>.>>>.>>>>>>>....<<<<........>>>><<<<<<.....<<<<<.<<<<<<..<<<...<<.<.....>.>>...>>>...<......>......<<<<<..<<<<<....>>>>>...>>>>><<<<<<<<<....<....>....>>>.>>>.>>>...>>>>>>.>>>>>...<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<.<....<<<.<<<<<<<.....<<<....<<<....<<<....<<<<<<.....>>>>>>..>>>....>>>..>>.>.....>>>>>...<<<<<<<<<.........>>>>>>>>>....>>>>>.>.>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<......<<..........<<<.<<<<<<.<<<.......<<<<<.<<.....<.........>.....>>.........<<......>>...>>>>>...>>>.>>>>>>>>>..........))).>>...>>>>>>.>>>...>>>>>>><<<<.<<<<.........>>>>.>>>>....>>>>>><<<<<<<<<<<........<<<.<<<<....>>>>>>>.....>>>>>>>>>.>>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<...<<<....>>>........<<<<<....>>>>>...>>>....>>...<<<<<........>>>.>>))<<<<.<<<<..<....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<.<<<<...[[..>>>>.><...<<<<<.....<<<<<<.....<<.....>>.....>>>>>>.....>>>>>....><<<<..........>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>....>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<....<....>.....>>>>><<.<<<<<<<<<<<.<<<<<<<<.<<<<<<..<<<..<<<<<<<<<<<.<<<<<<.<<<<<<..<<<<<....>>>>>..>>>>>>.>>>>>>>>.>>>>>>..>>>..>>>.>>>>>>...<<<<......>>>>...>>>>>>>>......>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<..<<....<<<<....>>>>......>>....>>>...<<<.<<<..<<<<<<.<...<<.....<<<<....>>>>.....>>.>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>........>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<.<<<...<<<<<<<<<<<<<<<<<...........<<<<..<<<<....>>>>............>>>>..>>>>>>>.>>>>>>>>>>...<<<<<.....<<<<...<<<..........>>>................<<<<<....>>>>>..>>>>..>>>>>......>>>.>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))......<<<<<<<.<<<<.))))))>>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<<<.<.<<<......>>>.>...>>>.<<<.<.....>.>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>....<<<<<<<..<<<<.<.<<<<<.................>>>>>.><<<<<...<<<<....<<<<<<<<<.]]...>>>>..>>>>>...>>>>..>>>>>..<<<...<<<<<...........>>>>>...>>>..>>>>....>>>>>>>....<<<<<<<<<<<<......<<<......<<<<..<....>.>>>>..>>>...........<<<...<<<<<<.<<<<......>>>>.>.>>>>>.>>>..................>>>>>>>>>>>>.<<<<<.<.............>.........<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>.........>>>>>.. ..........................((((......(...[..).......))))...........((....))...((((.......(.]...)......))))...((((.........((((((((((...)))))))))....)........((((((.((.(.((.((((.(((((((...(.((((......)))))[[(...).(((.....]])))....)))))))...)))).)).....).)))))).))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).......................((((((((((.((....((((((((((...((((((.(.((....)).).)))).))...))).)))))))......(((((((((((.(((((((((......((((((((.....)))))))).....))))))))).))))))).....(((((((....)))((((((....)))))).))))..)))).....)).))).)))))))....((((........))))((((((....((((((.((((((..(((...((.........))...)))...(......)......(((((..(((((....)))))...)))))..(((((((....(....)....))).))).).....)))))).))))))..((.(...((((((.....(((((((((..(((....(((((((....)))))))....[)))...(((..((.((........)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((.(....(((.(((((((.....(((....(((..(.(((.....(((((.....)))))...))).)..)))..)).).....)))))...(((...(((.(......))))...)))....))))).).)))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((.......(..........(((.(((.((.(((.....{.(((((.(((....(.........)....))).....(...(........).).)))))...))).)).))))))..........]]].)....))))))))))...)))))))((((.((((.........)))).))))....))))))(.((.((((((........(((.((((....))))))).....)))))).))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...(((((...............)))))....[[(((.((...((....(((....))).........((((....)))).....))....))...((((..........)).))]]((((..(((..(...((((....)))...(...((((((...((((.(((((((...(((.(((....{{...))).)....(((((.....(((((.....((((...)))).....))))).....))))).....((((..........)))))).....))))))).))))(...)....))))))...)).....)....))).)))).)))..)).....((......)).)))).((((.....))))..)))...((((.....(((((((.((..(............(((((....(.{..).....)))))((.(((((((((((.((((((((.((((((..(((..((((.((((((.(((((....((((..((.((....)).))..))))....))))))).)))).)..)))..))).))))))...((((......))))...))))))))......)))))..)))))).))(...).......(((((((((.].((.........))...(((........((((....))))............))).}.(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........((((.........))))..)..)....)))........)).)))))))....))).)))))))..))))))....)).[..(((((......].)))))....(((((..(((.((......((((.((((((..(((((.(((.(((...(((((((.(.((.(.((...{...[....((...((((....)))).......}..]..))...)).).))..).)))))))....((((.....((((...(((..........))).................(((......)))...))))..)))).......))).)))..)))))...((......[))....((((..........]))))..([((...((.((((...((((((.......)))))).....((][.[[[))....)))).))...(((..((((....{..))))..))).(((....))).))]]].].....((((((.((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(((.(.(((......))).)...))).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))....))..))).)))))....(((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((.(}}..).)))..)))))...))))..)))))..(((...((((.....}.......))))...)))..))))....)))))))....((.((.(((((.......(((......(.((.........)).)..)))...........(((...((((....(((......))).....)))).)))...................))))).)).)).(((((.(..(.......)..).......(.((((..(((....((((.(..(.((((..)..))).)..)))))...))).....))).))........))))).. Model of the small subunit RNA based on a 5.5 A cryo-EM map of Triticum aestivum translating 80S ribosome; 60S ribosomal RNA 4v7e Ac 160 5.5 RF00002 URS000080DD3B_4565 24499919,20980660,20974910 0003735 0005840 4565 cgacucucggcaacggauaucucggcucucgcaucgaugaagaacguagcgaaaugcgauaccuggugugaauugcagaaucccgugaaccaucgagucuuugaacgcaaguugcgcccgaggccauccggccgagggcacgccugccugggcgucacgc .........................................<<<<<<.<<.....>>>....((.<<<......>>..............>>>..))..>>>....<<.....>><<<<..<<<<....>>>>..>>>>..................... .........................................(((((..[[......))....((.((((...(.]].)..........).)))..))..)))....((.....))((((..((((....))))..))))..................... Model of the small subunit RNA based on a 5.5 A cryo-EM map of Triticum aestivum translating 80S ribosome; 5.8S ribosomal RNA 4v7e Ab 120 5.5 RF00001 URS0000188192_4565 24499919,20980660,20974910 0003735 0005840 4565 ggaugcgaucauaccagcacuaaggcaucggaucccgucagaacuccgaaguuaagcgugcuugggcgagaguaguacaaggaugggugaccucuugggaaguccucguguugcauuccc <<<<<<<<<....<<<<<<<......<<<<<<............>>>>..>>.....>>>>>.>><<<<<.......<.<<<<.<<....>>>>>>.>......>>>>>>>>>>>>>>.. ((((((((.....(((((((......((((((...(....)...))))..)).....))))).))(((((.......(.(.((.((....)))).).)......))))).)))))))).. Model of the small subunit RNA based on a 5.5 A cryo-EM map of Triticum aestivum translating 80S ribosome; 5S ribosomal RNA 4v7f 1 3394 8.7 RF02540,RF02543 URS000061F377_4932 24662372 0003735 0005840 4932 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........................<<<<<<<....<.....<>.>....>>>>>.>...{.....<<....>>..<<<<<.<....<<...>.>>>....>>>>>..[[[..<<<......<<.<<<<<<...>>>>>>.>>......>>>....<<<<<<<.<<<<<<<<<<<<<<<<<<<<.....<<<<......>>>>.(.......<<<......)>>>....>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]....}.............................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<.....<<<<<...<<<..<<<<<<.<<<....>>>>>>>>>......>>>...>>>>>.<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<.<.<....>.>.>><<<<<<...<.<<<<<.<<<<<<..<<<<.<<<<<.....>>>>>.>>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<......<<<....>>><.<<<<<<<<<<...<<<.<<<<<<..<.<.<<<....<<<....<<<<<..<<<<<<.....>>>>>>>>>>>....>>>..>.>>>..>..>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>>.<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<<....<<..........<<<.<<<<<<<<<......<.<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>.>..>>>>>>>>>>>>..........))).>>..>>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>>..(<<<<<<..<.......<<<<.<<<<....>>>>>>>>...)>.>>>>>>.........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<<...<<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<...<.<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>....>.....>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>><<<<.....>>>>.>>>>>..<<<<.....<<<<<<<.<<........<<.....<<<<<...............>>>>><<.<<<<<<<<<<<.<<<<<<<<.<<...<<<<....<<<<<<<<<<<<<..<<<...<<<<<<<<<<<<....>>>>>>>>>>>>...>>>..>>>>>>>.>>>>>>....>>>>...>>.<<<<<.....>>>>>....>>>>>>>>......>>>>>..>>>>>>.>>............<<<<<<<<<..<<...........>>..<<<<<<<....<<<<.....>>>>......>>>>>>>.......<<<..<<<<<.<<..<<<....<<<<<....>>>>.>...>>>>>>>>..>>>>>.<<<<<.......>>>>>...........<<.<<<<...<<<<<.......>>>>>..>>>>...>>......>>.>>>>>>>..>>.>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..[[[.{{.........{....[[[..<<<<<.<<<<<<<<..<<<<<<<<<<<<<<<<<..........<<<<<......................>>>>>.>>>>>>>.>>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>..............<<<<<<<<...........>>>>>>>>.....<<<<<<<...<<<<<<.......>>>>>>.....<<......>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.............((((((..((((.>>>>>>))))))))))..........]]].....}.................<<<<<<<..<<.......>>>..>>>>>>..................<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.<.....>.>>>.....>>>>>..>...>>>.......<<<<<<<....>>>.>>>>....}}..]]].]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<<..<<<<<<<<<<.}}}..>>>>..>>>>>>.>>>>>..>>>>>.<<<<<..<<<<<...........>>>>>..>>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<..<<.....>>..>.....<<<<<<<<<.<<<....<<<<.<..<<<<........>>>>..>>>>>...>>>....>>>.>>>>>>..>>>>>.. ........................((((((.....(......)......))))).)...(.....((....))..(((((......((.....)).....)))))..(((..((.......((.((((((...)))))).)).......))....(((((((.((((((..(((.((((.(((.....((((......))))..[......(((.....].)))....))).))))...)))..))....)))))))))))........(((.((..........)).))).....(((((..[[[[[[)))))..)))....).............................((....))...............((((....))))..................................(((((.((((((.....((((...((.(.((.((...((....))..)).)).....).))...))))..(((((((.(((((((.(.(((((.....(((((((((......((((.((..)).)))).......))))))).).).)))))..).)))))))........(((....))).....)))))))....)))))).)))))..((............))((((((....((((((.((((((..(.(...((((.....))))...).)...((....)).......(((((..(((((....)))))...))))).(((.((((....(....)....))).).).))....)))))).))))))..((.(...((((((.....((((((.((..(.(....(((((((....))))))).....).)...(((..((.((........)))).)))....)).))))))....(.......).......))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((.....(.(((....(((....((((....((((.......))))..))))....)))..)).))......)))...((((..(((.(......))))..)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((..(((([[[.....((((((.....((..........(((.(.((((((((.....(.(((((.((....((.........))....)).........((......))...))))).).)))))))).))))..........]]].))...)))))).))))..)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((.((.((...((((((...((.....)).))))))....[[(((.((...((....((......))........((((((........))))))....))....))....((((........)))).]]((((..(((.(......(((....))).......((((((...((((.(((((((.(.((((.(((..{{{..))).))(...(((((....(((((......((.....))......))))).....)))))....)(((((((......))))))))).)...))))))).)))).........))))))...........)...))).)))).)))..)).....((......)))).)).((((.....))))..))))..((((.....(((((((.((.........(.....(((((....(....).....)))))((.((((((((((..((((.(((..((..((.......((((((((.(((..((.(.(.((.(.(..(.(....).)..).).)).).).))..))).))).))))).......))..))..(((((.....)))))....))).)))).......))))..)))))).))............(((((((((..(((.........)))..(((((((....((((.....))))......))))))).......(((..((.(((.(...(......((((....))))......).))))...)))))..(((((....).))))............((.((((...(((((.......)))))..))))...))......)).)))))))..)..)).)))))))..))))))....)).[..(((((......].)))))....(((((...((.((........((...((((..((((..(.((((((..((.((((.(.(((.(((..........(((((......................))))).))).)))..).)))).))...(((((.....((((..(((((......)))))...............((.(((....))).))..))))..))))).....)))))).)...))))..............(((((((.............)))))))......((((((...((((((.......)))))).....((......))....))))))....(((.((((.........))).)))).((......)).............((.(((..((((.]]]]]]))))))).))..........))))....))................((((.(...((.......))...).))))..................(((.((((((..(.(((((((......)))))))...).(((.(.....).))).....)))))..)...))).......(((((((....))).))))....))..))..))))).....(((((((..((((...((((((...............))))))..(((((...(((((...((((((((((}}}.)))))..)))))..)))))..))))).((((...((.((...........)).))...)))).))))....))))))).......(((((((.(((.((....((.(........((((((.....)))))).....))).......((.(((....((((.(..(((......)))..).))))..))).)).............)).))).)))))).)(((((.(.............).....(((((((((.(((....((((....(.(..........).)...))))..).))....)))).)))))..))))).. Arx1 pre-60S particle.; 25S ribosomal RNA 4v7f 2 158 8.7 RF00002 URS00001BF64E_4932 24662372 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<<<<<...>>>>.....<.<<<.....>>>..............>>>..>...>>>....<<<...>>><<<<<<<<<....>>>>>>>>>..................... ..........................................(((((.[[.....))).....(.((((.....]]............).)))..)...)).....((.....))(((((((((....)))))))))..................... Arx1 pre-60S particle.; 5.8S ribosomal RNA 4v7h AA 1761 8.9 RF01960,RF01959,RF00177 URS000080DF0D_5541 20004163 0003735 0005840 5541 uaucugguugauccugccaguagucauaugcuugucucaaaguuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuauguuuauuugauagacauggauaaccgugguauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuugaugguaggauaguggccuaccaugguuucaacggguacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggaggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugacuuugggcccgguuggccgguccgauuuuuucguguacuggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacuuugguucuauuuuguugguuucuaggaccaucguaaugauuagggacggucgggggcaucgguauucaauugucgaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucugguaccgucguagucuuaaccauaaacuaugccgacuagaucgggugguguuuuuuuaaugaccacucgguaccuuacgagaaaucaaagucgguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcacccuaggaguggagccugcggcuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguuucuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucuguaugcccuuaacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggauca ...<<<<<.[.((((>>>>><<<<..<<<<<.....<.........<<<.<<<..<<...<<..........<<.......>>..>>>>......<<........<<<..<<.<<....<<<.....<<<.....<..<<......>>..>......>>>........<<<<..<<....>>..>>>>.......<<<<.........<<<..<<<....>>>....>>>.......>>>>................<.<........>>........>>>...>>>>..>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<.<<.<.........>>>.>>...<<....>>.....>>>>>>.........<<<....<<<.....>>>..>>>.......>.......<<<<<<....<<<....>>>....>>>.>>>..........<<..........>>.............<<<<(((....<<<<.....<..))).>.......>>>>.>>>>...>>>>>.>>>>.........<<<((.....<.<<...<<<.......<<<<<..<...<<<<<<<<<.....>>>.>.>>>>>.......>..>>>>>..<<<......<<.......<<<<<<.<<.<<.....>>..>>.>>>>>>..<<<<<<<.....>>>>>>><<<....<<<<.....>>>.>..>>>.....>>...<<<<<<<<<<<<<<<<<<....>>>>>>>>>>>>>>.>>>>..>>>...............<<<<<<.<<...<<<<......<<<<<<.<..<<<......>>>......>.>>>>>.>..........<<....>>...>>>>...>>>>.>>>>...>>>...>>.>....<<<<<<<.......<<<<.<.....>.>>>>....>>>>>>>..........<<<<<.....<<<<<<<<..<<........>>>>>>>>>>........<<..))>>....>>>>>.>>>.<<<......<<<......>>>....>>>..)))).]<<<<<.<<<<<<<.....<<<<<..<<<.<<<<<<.....<<........>>..........<<<<<.<.....<<<<.<<........<<<........>>>.......>>>>>>....<..<<<..<<<<<<<<.....<<<.<<<<......>>...<<<......>>>...>>.>>>....<<<<<.<<<...<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>..>>>....<<<<<<.....>>>>>>.......>>>>>.....>>.>>>...>>>>>>.>....>.>>>>>...>>.>>>>.>>>.....<<<<<<<.....<<<....<<<................>>>...>>>......>>>>>>>......<..<.<<<<..............>>>>>...>.....>>>>>.....<<<<<<<<.......>>>>>>>>...........>>>>>>>>>>.>>.......<<.<..<<<..<<..<.<<<<<<<<.<<<....<<..<...<<<<<<<.<<<<.<<<<....>>>>.>>>>.>>>>>>>...>..>>....>>>.>>>>>>>>>..>>..>>>...>.>>..........<<<<<<<<....>>>>>>>>....... ...((((..[.[[[..)))).(.(..((.((...(.(...((....(((.(((.......(((..........(.......)..)))........(((.......(((..((.((....(((....(.((.....(..(.(....).)..)......)).).......((((..((....))..))))......(((((.........(((..(((....)))....))).......)))))...............(...........)........)))...))))..))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.....))).))))).)....).).....(((.(..(...((....))...)..)..)))..........(...........)..............(((([[[....((((.....((.]]])).......)))).))).)..)).)).).)..........((([[...(.(.((...(((.......(((((.(....(((((((((.....))).).)))))........).)))))...........(........((((((.((.((.....))..)).))))))..(((.(((.....))).)))(((....((((.....))))...)))......)...((((((((((((((((((....)))))))))))))).))))....................(..(((.((...((((..((..((((((.(..((........))......).))))))..)).......((....))...))))..)).)).)..)...)))...)).)....((((((........((.(.........).)).....))))))..........((((..(...((((((((..((........))))))))))........((..]]))...).)))))))).(((......((((....))))....)))...]]].](((((.(((((((..(..(((((..(((.((((((.....((........))..........(((((.(....(((((.((......(.(((........))))......)))))))...((.(((...(.((((((....(((.(((((....)))...(((......)))...)).))).....((((.(((...((..((((((((.(((....))).)).).)))))..))..)))..(.((((((.....))))))....)..)))).....))).)))....).)))))....).)))))...)).)))).))).(...(((((((.....(((....(((.....(....).....)))...)))......)))))))......(....(((................)))....)..)..))))).......((((((.......))))))........)....)))))))))).)).......((.(..((((.((..(..(((((((.(((..(.((..(...((.(((..(((..((((....))))..)))..))).))...)..)).)..))).))))))).)..)).))))...).)).........(((((((((....)))))))))...... Structure of the 80S rRNA and proteins and P/E tRNA for eukaryotic ribosome based on cryo-EM map of Thermomyces lanuginosus ribosome at 8.9A resolution; 18S rRNA 4v7h A7 76 8.9 RF00005 URS000011107D_5541 20004163 0030533 0006412 5541 gcggauuuancucagnngggagagcnccaganunaanaunuggagnucnugugnucgnuccacagaauucgcacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((.........)))).....(((((..]....)))))))))))).... Structure of the 80S rRNA and proteins and P/E tRNA for eukaryotic ribosome based on cryo-EM map of Thermomyces lanuginosus ribosome at 8.9A resolution; P/E tRNA 4v7h B3 113 8.9 RF00001 URS000080DDB9_5541 20004163 0003735 0005840 5541 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguguuaagcuguagagccgacaguaguguagggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<..........<<..<.............>...>>..........>>>.<.........<<<<.<<...>>.>>>>.........>..>>>>>>>>>. ((((((((.....((..........(.(.......(....).......).)..........)).(.........(.((..(...)..)).).........)...)))))))). Structure of the 80S rRNA and proteins and P/E tRNA for eukaryotic ribosome based on cryo-EM map of Thermomyces lanuginosus ribosome at 8.9A resolution; 5S ribosomal RNA 4v7h B4 157 8.9 RF00002 URS000080DE78_5541 20004163 0003735 0005840 5541 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaauguagguugcagaauuccgugaaucaucgaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<........>>>.......<<<......................>>>.....>>>...............<<<<<<<....>>>>>>>....................... ..........................................(((((......[.))).......((...((.].......))........)).....))........(...)...(((((((....)))))))....................... Structure of the 80S rRNA and proteins and P/E tRNA for eukaryotic ribosome based on cryo-EM map of Thermomyces lanuginosus ribosome at 8.9A resolution; 5.8S ribosomal RNA 4v7h B5 3170 8.9 RF02540,RF02543 URS000080DFA9_5541 20004163 0003735 0005840 5541 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.........................((((((...................))))).).........((....))...((((......((.....)).....))))...((((.........((..(((((.....)))))..).)............((((((...((.((..((((((((.(....((((........))))[[(...).(((.....]])))....).)))))..)))..)).....))..))))))....)....((((..............)))).....(((((......)))))..)))..................................((....))...............((((....))))..................................((((....((.......((.........(..(((((.....))))).)..............))......(..(((.(((.((((..((((.........(((((....(((((((((..)))))))..))...))))).......))))...)))).))).).......(((....))).....))..)........))....))))...(((........)))..(((.........(((.(((..(..(.(...((.....))...).)..................(.(((...((((....))))....))).)...(.((((....(....)....))).).).......)..))).))).....((.(...((((((.....(((((((((....((...((((.(......).))))...).).....(.(..((((........)))).).)....)))))))))....................))))))......).))..(((((.....(.(.(....).).)((....(.......((((.(...(((...(.(..(.....(.(((((....))))).).....)..).)..)).).....)))))....(((.((((.........)))).)))...............)....))..((((.((((.......)))).))))....(((......)))...((((((....(((......(.(((((.(..........(.(.((((.(((.(.......(((.(..((...................))..........((......))...).)))...).))).))))).)..................))))))))))....))))))((.(.(((..))).).)).....)))))(...((...(((......(((.((........)).)))...)))...))....).......)))........((.....((((((.......))))))..((....(..(..((..(((((.(...((.....)).).))))....[.((..(.......(((.((....)))))......((((((........))))))..........)...(((((........))))).](((.(((.......(......)............(....(.((..((..((.((((((......[..))))))(...(((.........(.....(.....).....)...........))).....)...(((((....))))).....))....))...)).)(..)......).................)))...)))..)).)))................)..).(...........)..))....((.(.....(.((((.((..(....(.......(((((....(.[..).....))))).(.((((...)))).).(...).......(((((.(((...((.........))....((((((.....(((....))).......))))))..].(((..((..((((....................................))..)))).(((((.........)))))........((.............................)..)....)))....)).).))))).)..))).))))..)..).))))..........(((((........)))))....((((...(((.((.......(((.((...(..((..(.((((((((...(.(((((((...(.............(...(......................)...)....)...))))))).)....(((((.....((((..(((((......)))))..................(((....))).....))))..))))).....))))))))..)..))...((.......))..(((...............))).(..(....((((((.(.(((((.........)))))...)..([...[)......))))))....(((...((........))...))).............).]..].......(((................)))......).....).....))))).........(.....((((((...((.......))...))))))......)..........((((...((((..(.(((((((......))))))..).).(((.(.....).))).....)))).......))).)......((((((....))).))).....))..)))..))))........(.....(.((...(((((......(....).....)))))..(((......((....(((((.(((((]...)))))...)))))...))....)))...(....((.(.............).))....)...)).).......)...............((..((.(..................(...(.....)...)................((((((((..(.((..(...(......)....).)).)))))))))..............).))..)).......((..(..(.......)..).....((((((((...(....(.((.(..(((((......)))))..))).)...)....))))))))...)).... Structure of the 80S rRNA and proteins and P/E tRNA for eukaryotic ribosome based on cryo-EM map of Thermomyces lanuginosus ribosome at 8.9A resolution; 26S ribosomal RNA 4v7i A7 117 9.6 RF00001 URS0000049E57_562 19913480 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggc <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.....<..<<<<<<<...>>>>>>>....>...>>...>>>>>>>>> (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))) Ribosome-SecY complex.; 5S ribosomal RNA 4v7i A8 2903 9.6 RF02540,RF02541 URS00004B0F34_562 19913480 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<......<<..<<<<<<<<<<<<<......<<<<<<....(((.>>>.....<<<<<<<..<<.))).....>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<......<<<<<<<<<<<<<.<<<...<<<<........>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..(((.>>>>>..>>>......>>.>>>>>>>.>>...............<<....>>....>>.........<<<<.....>>>>...................>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>..................<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>...<<<.....>>>......>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.<...<<<...<<<.<<<<...<<<<<<<.....>>>>>.>>...>>>>.>>>..>>.>...>.>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<<..<<<<.......>>>>..>>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<....<<.....>>..>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<...<<<..<<<<<<<<<<<....[[[...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>>...<<<<......>>>>....>>>>>...>>>....>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<....<<<.....>>>....>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<..<<....>>...>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<..........>>>>..<<<<<<<<.<<<.<<......<<<<.<.<<<<..<<<<..<<<.<<<<..<<<<<<<<<<..<<<<.<..........<<<<...........<<<<<<<<....>>>>>>>>..................>>>>.>.>>>>..>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>.....>>>>.>>>...>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<......)))....>>>>>>>.............>>>>...>>>>>....<..<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.>.....<.<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>..>....<<<<<<<....>>>.>>>>....>>..>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<.<<<<<<]]].>>>>>>...>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<<...>>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((...(((((((((.....(((...(((.((((...(((.(((.....))).).))...)))).)))..)).).....)))))).)))...))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.......(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((..((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((((((((((...((((....((((..(((..(((((((((((....{{{...))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((((.(......[....(((...........((..((((....))))..))................].)))..).)))).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.((((((...))))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Ribosome-SecY complex.; 23S ribosomal RNA 4v7i BA 1530 9.6 RF00177,RF01959,RF01960 URS00000ABFE9_562 19913480 0003735 0005840 562 ugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggauca ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.<...<<<.<<<..<<<..<<.<...<<<<<<<<<<....>>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>...>>>>>.>>.<<<<<............>>>>>.<<<<....>>>>...>>>>>>.>.......<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<.<<.......>>>.>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<(((....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<).))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<........<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>..<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<..<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>.........>>>.......>.>>>...>>>>>>>>....>>>>>>>......>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<..<<<...<<....>>..>>>.>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>...... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((((((((..)))))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(...(((..((.(.......)))...)).)...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))...((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....))))))).....(((((.....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.....]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Ribosome-SecY complex.; 16S ribosomal RNA 4v7j Aa 1504 3.3 RF00177,RF01959,RF01960 URS000080E260_274 20005802 0003735 0005840 274 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<.........>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>.....<......>.....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<....<<.....>>.>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<...<<<<....>>>>...>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<<..>>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(.((.((...........)).)).).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((.....)))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((.(..(((((((.((......((........))..........(((((((..(...(((((.......(.(.(....).).)......................)))))).((.(((...((((.(.(....(((((((((....)))...(((......)))...)))))).....((((.(((((.(..(.................)...).))))).....(((((....)))))........)))).....).)..))...)).)))))....)))))))...))..))))))).(...(((((((.....(((......((((....))))........))).....)))))))......(....(((((((........)))))))....)..)..).))).....(((((((..........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Structure of RelE nuclease bound to the 70S ribosome (precleavage state); RNA (1504-MER) 4v7j Ax 12 3.3 URS000080E2A4_32630 20005802 32630 aaaaugnnnaaa ............ ............ Structure of RelE nuclease bound to the 70S ribosome (precleavage state); RNA (5'-R(*GP*GP*CP*AP*AP*GP*GP*AP*GP*GP*UP*A*AP*AP*AP*AP*UP*GP*(OMU)P*(A2M)P*(OMG)P*AP*AP*AP*A)-3') 4v7j Av 77 3.3 RF00005 URS000041AF00_274 20005802 0030533 0006412 274 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>......<<<<.......>>>>.>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Structure of RelE nuclease bound to the 70S ribosome (precleavage state); RNA (77-MER) 4v7j Aw 77 3.3 RF00005 URS000041AF00_274 20005802 0030533 0006412 274 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<...<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>.>>>>>..... .(((..(..(((...........))).(((...........))).....(...(.......)...))..)))..... Structure of RelE nuclease bound to the 70S ribosome (precleavage state); RNA (77-MER) 4v7j AA 2848 3.3 RF02540,RF02541,RF00002 URS000080E03F_300852 20005802 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucgggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgggccgcacgcggcccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccagucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<....>>>>>>.>>....<<<<<.....<<....>>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>.....<<<<<<<<<....<<<...<<<<..<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>...>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....<<<<.<<....>>.>>>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<....>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<.........>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (........((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((((((((..).))))))))....((((((((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...........................)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((.(.((((((......)))).)))..))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((((((..................))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.((...{{....))))))(((...((((((((((.(((((.((.....))))))).).....)))))))))..)))(....((......))......))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((((.......)))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((.(((.((((........[...((((...(.........(...((....))....).....)...........].))))...)))).))).)))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))...(.........).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))......) Structure of RelE nuclease bound to the 70S ribosome (precleavage state); RNA (2848-MER) 4v7j AB 119 3.3 RF00001 URS000080DE2B_300852 20005802 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>> .((((((((((....(((((..(....(((((((...(.....)...))))..)))...)..))).))(((.......((.(((((....))))).)).......))).)))))))))) Structure of RelE nuclease bound to the 70S ribosome (precleavage state); RNA (119-MER) 4v7j Ba 1504 3.3 RF00177,RF01959,RF01960 URS000080E260_274 20005802 0003735 0005840 274 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<.........>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>.....<......>.....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<....<<.....>>.>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<...<<<<....>>>>...>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(.((.((...........)).)).).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((.....)))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((.(..(((((((.((......((........))..........(((((((..(...(((((.......(.(.(....).).)......................)))))).((.(((...((((.(.(....(((((((((....)))...(((......)))...)))))).....((((.(((((.(..(.................)...).))))).....(((((....)))))........)))).....).)..))...)).)))))....)))))))...))..))))))).(...(((((((.....(((......((((....))))........))).....)))))))......(....(((((((........)))))))....)..)..).))).....(((((((..........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((.....((((....(((....))).))))....)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Structure of RelE nuclease bound to the 70S ribosome (precleavage state); RNA (1504-MER) 4v7j Bx 12 3.3 URS000080E2A4_32630 20005802 32630 aaaaugnnnaaa ............ ............ Structure of RelE nuclease bound to the 70S ribosome (precleavage state); RNA (5'-R(*GP*GP*CP*AP*AP*GP*GP*AP*GP*GP*UP*A*AP*AP*AP*AP*UP*GP*(OMU)P*(A2M)P*(OMG)P*AP*AP*AP*A)-3') 4v7j Bv 77 3.3 RF00005 URS000041AF00_274 20005802 0030533 0006412 274 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Structure of RelE nuclease bound to the 70S ribosome (precleavage state); RNA (77-MER) 4v7j Bw 77 3.3 RF00005 URS000041AF00_274 20005802 0030533 0006412 274 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .(((.(...(((.......[...)))..(((.........)))......(...(..]....)...).).)))..... Structure of RelE nuclease bound to the 70S ribosome (precleavage state); RNA (77-MER) 4v7j BA 2848 3.3 RF02540,RF02541,RF00002 URS000080E03F_300852 20005802 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucgggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgggccgcacgcggcccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccagucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<....>>>>>>.>>....<<<<<.....<<....>>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>.....<<<<<<<<<....<<<...<<<<..<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>...>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....<<<<.<<....>>.>>>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<....>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<.........>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (........((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((((((((..).))))))))....((((((((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...........................)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((.(.((((((......)))).)))..))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((((((..................))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.((...{{....))))))(((...((((((((((.(((((.((.....))))))).).....)))))))))..)))(....((......))......))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((((.......)))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((.(((.((((........[...((((...(.........(...((....))....).....)...........].))))...)))).))).)))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))...(.........).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))......) Structure of RelE nuclease bound to the 70S ribosome (precleavage state); RNA (2848-MER) 4v7j BB 119 3.3 RF00001 URS000080DE2B_300852 20005802 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>> .((((((((((....(((((..(....(((((((...(.....)...))))..)))...)..))).))(((.......((.(((((....))))).)).......))).)))))))))) Structure of RelE nuclease bound to the 70S ribosome (precleavage state); RNA (119-MER) 4v7k Aa 1504 3.6 RF00177,RF01959,RF01960 URS000080E260_274 20005802 0003735 0005840 274 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<.........>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<....<<<<<<....>>>>>>.....<.......>.....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<....<<.....>>.>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<...<<<<....>>>>...>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<<..>>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((.........)))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.(((((((((.......((((((.....)))))).....)))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(..(((((((...)))))))..)...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((.(..(((((((.((......((........))..........(((((((..(...(((((.....(((.(.(....).).)))....................)))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...(..............).....))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))...))..))))))).(...(((((((.....(((......((((....))))........))).....)))))))......(....(((((((........)))))))....)..)..).))).....(((((((..........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Structure of RelE nuclease bound to the 70S ribosome (postcleavage state); RNA (1504-MER) 4v7k Ax 13 3.6 URS000080E16E_32630 20005802 32630 aguaaaaauguan ............. ............ Structure of RelE nuclease bound to the 70S ribosome (postcleavage state); RNA (5'-R(*A*AP*GP*UP*AP*AP*AP*AP*AP*UP*GP*UP*A*(CCC))-3') 4v7k Av 77 3.6 RF00005 URS000041AF00_274 20005802 0030533 0006412 274 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Structure of RelE nuclease bound to the 70S ribosome (postcleavage state); RNA (77-MER) 4v7k Aw 77 3.6 RF00005 URS000041AF00_274 20005802 0030533 0006412 274 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((.(..(((...........))).((((.........)))).....(.(.(.......).).)).))))..... Structure of RelE nuclease bound to the 70S ribosome (postcleavage state); RNA (77-MER) 4v7k AA 2848 3.6 RF02540,RF02541,RF00002 URS000080E03F_300852 20005802 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucgggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgggccgcacgcggcccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccagucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu .<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<....>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>.....<<<<<<<<<....<<<...<<<<..<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>...>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.......<<<<<....>>>>>......>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<....>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<.........>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>. .........((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...(((((((((..).))))))))....{((((((((.....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))).))))).))))....(((((((((.[.....)))))))))....}.(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...........................)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((.(.((((((......)))).)))..))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((................)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.((...{{....))))))(((...((((((((((.(.(((.((.....))))).).).....)))))))))..)))(.....((....)).......))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((((.......)))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((.(((.((((..............((...((......(.((((((....))))).))...)).............)).....)))).))).)))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))...(.........).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....... Structure of RelE nuclease bound to the 70S ribosome (postcleavage state); RNA (2848-MER) 4v7k AB 119 3.6 RF00001 URS000080DE2B_300852 20005802 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>> ..(((((((((....(((((..(....(((((((...(.....)...))))..)))...)..))).))(((.......((.(((((....))))).)).......))).))))))))). Structure of RelE nuclease bound to the 70S ribosome (postcleavage state); RNA (119-MER) 4v7k Ba 1504 3.6 RF00177,RF01959,RF01960 URS000080E260_274 20005802 0003735 0005840 274 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<.........>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<....<<<<<<....>>>>>>.....<.......>.....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<....<<.....>>.>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<...<<<<....>>>>...>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<<..>>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((.........)))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.(((((((((.......((((((.....)))))).....)))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(..(((((((...)))))))..)...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((.(..(((((((.((......((........))..........(((((((..(...(((((.....(((.(.(....).).)))....................)))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((.(...(..............).....).))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))...))..))))))).(...(((((((.....(((......((((....))))........))).....)))))))......(....(((((((........)))))))....)..)..).))).....(((((((..........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Structure of RelE nuclease bound to the 70S ribosome (postcleavage state); RNA (1504-MER) 4v7k Bx 13 3.6 URS000080E16E_32630 20005802 32630 aguaaaaauguan ............. ............ Structure of RelE nuclease bound to the 70S ribosome (postcleavage state); RNA (5'-R(*A*AP*GP*UP*AP*AP*AP*AP*AP*UP*GP*UP*A*(CCC))-3') 4v7k Bv 77 3.6 RF00005 URS000041AF00_274 20005802 0030533 0006412 274 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Structure of RelE nuclease bound to the 70S ribosome (postcleavage state); RNA (77-MER) 4v7k Bw 77 3.6 RF00005 URS000041AF00_274 20005802 0030533 0006412 274 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .(((.((..(.(.......[...).).(((((.......))))).....(((((..]....))))))).)))..... Structure of RelE nuclease bound to the 70S ribosome (postcleavage state); RNA (77-MER) 4v7k BA 2848 3.6 RF02540,RF02541,RF00002 URS000080E03F_300852 20005802 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucgggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgggccgcacgcggcccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccagucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu .<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<....>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>.....<<<<<<<<<....<<<...<<<<..<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>...>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.......<<<<<....>>>>>......>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<....>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<.........>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>. .........((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...(((((((((..).))))))))....{((((((((.....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))).))))).))))....(((((((((.[.....)))))))))....}.(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...........................)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((.(.((((((......)))).)))..))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((................)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.((...{{....))))))(((...((((((((((.(.(((.((.....))))).).).....)))))))))..)))(.....((....)).......))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((((.......)))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((.(((.((((..............((...((......(.((((((....))))).))...)).............)).....)))).))).)))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))...(.........).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....... Structure of RelE nuclease bound to the 70S ribosome (postcleavage state); RNA (2848-MER) 4v7k BB 119 3.6 RF00001 URS000080DE2B_300852 20005802 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>> ..(((((((((....(((((..(....(((((((...(.....)...))))..)))...)..))).))(((.......((.(((((....))))).)).......))).))))))))). Structure of RelE nuclease bound to the 70S ribosome (postcleavage state); RNA (119-MER) 4v7l AA 1495 3.0 RF00177,RF01959,RF01960 URS000080DD29_300852 20154709 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<......<<<.<<<..<<<..<<.<<<<<<<..>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>...>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<.<<..<<<<<<<....>>>>>>>....<<.....>>....>>.>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<...<<<<....>>>>...>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(.(..((.(.((((....)))).).))).)......(((......(((.((((..((...(((((((.(((((....(((((......))))).....)))))....((((.(.(((....))).).))))...((((...)))).)))))))..)))))).)))(((....((...((((((((.......)))))))).))......)))..((((((((....))))...))))))).(((((.(.........)))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.(((....(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))....)))....((((((...((...((((.........))))...))))))))......{...((((((..((((.(((((...))))).))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((....((((((((((......((........))..........(((((((..(....((((.(....((((((....))))))....................))))).).((.(((...((((((.(....((((((.((....))....(((......)))...)))))).....((((.(((((((...(..............).....))))))).....((((......))))........)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((...(..((((....))))..).....))).....)))))))......(....(((((((........)))))))....)..)....))).....((((((............))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.. The structures of viomycin bound to the 70S ribosome.; 16S ribosomal RNA 4v7l AV 10 3.0 URS000080DEFF_32630 20154709 32630 aaaaugcagu .......... .......... The structures of viomycin bound to the 70S ribosome.; RNA (5'-R(*AP*AP*AP*AP*AP*GP*GP*AP*AP*AP*UP*A*AP*AP*AP*AP*UP*GP*CP*AP*GP*UP*UP*CP*AP*AP*UP*CP*UP*A)-3') 4v7l AW 75 3.0 RF00005 URS00004FF598_536056 20154709 0030533 0006412 536056 ugggguaucgccaagcgguaaggcaccggauucugauuccggcauuccgagguucgaauccucguaccccagcca <<<<<<<..<<<.........>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..(((.........))).(((((.......))))).....(((((.......)))))))))))).... The structures of viomycin bound to the 70S ribosome.; tRNA-Gln 4v7l AX 77 3.0 RF00005 URS000041AF00_536056 20154709 0030533 0006412 536056 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>......<<<<.......>>>>.>>>>>>..... .((((((..((((......[..)))).(((((.......)))))......((((..]....)))).))))))..... The structures of viomycin bound to the 70S ribosome.; tRNA-Met 4v7l AY 75 3.0 RF00005 URS000080E16B_536056 20154709 0030533 0006412 536056 ugggguaucgccaagcgguaaggcaccggauugugauuccggcuuuccgagguucgaauccucguaccccagcca <<<<<<<..<<<.........>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... ((((((...(.(..........)).((((.........))))......((...........))..)))))).... The structures of viomycin bound to the 70S ribosome.; tRNA-Gln 4v7l BA 2800 3.0 RF02540,RF02541,RF00002 URS00001698E8_300852 20154709 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucgggggcccucggccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccagucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu 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.........((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((......)))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(((((((((....(...(((((.((((...(...(((((......)))))[[(...).(((.....]])))...).....))))..)))))...)..))))).)))]....((((((((..[......))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))..)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((.(.(.((((......))))..))..)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((((......................))))))).))..........]]].)....))))))))))...)))))))(((((((.......)))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.((...{{....))))))(((...((((((((.(.(((((.((.....))))))).)......))))))))..)))(....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).))))..((((....))))...))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....((......)).......))))))).}((((.(((..(((((((...((...((...(((((....)))))...))...)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((.(((((.((((.(......[..(((.(...........((((((((....))))))))................].).)))).)))).))))).)))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))...................(((((((((.......)))))....((((((((.(((....(((.(....).)))...)))..))))).)))...))))....... The structures of viomycin bound to the 70S ribosome.; 23S ribosomal RNA 4v7l BB 118 3.0 RF00001 URS00005F2F4B_300852 20154709 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaaguaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<<....<<<<<<<<.....<<<<<...............>>>..>>...>>>>>>.>><<<.....<.<<<<<<<......>>>>>>>...>...>>>.>>>>>>>>>> .((((((((((....((((((((.....((((((...(.....)...))))..))...)))))).))(((.......((((((((....)))))))).......))).)))))))))) The structures of viomycin bound to the 70S ribosome.; 5S ribosomal RNA 4v7l CA 1495 3.0 RF00177,RF01959,RF01960 URS000080DD29_300852 20154709 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<..>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<.<..<<<<<<<.<..<<<......>>>.....>.>>>>>>>...>.......<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<.<<..<<<<<<<....>>>>>>>....<<.....>>....>>.>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<...<<<<....>>>>...>....>>>.....>>>>>>>......<..<.<<<<<<<........>>>>>>>>...>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....(((...[.[[[...)))..(((.(((((..(((((((((....(((.(((..(((..((..((((((..))))))..)))))......(((......((((((((..((...(((((((.(((((....(((((......))))).....)))))....((...(((((....)))))...))...(.((...)).).)))))))..))))))))))(((....(((..(.(.((((.......)))).).))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).......(((...(.(((....)))..))))..)).))))))..((((......((((....)))).....)))).....((((...(....((((.....)))).....)....)))).......((((([[[...(((((.....((.]]])).......))))))))))..))))))))...........(..[[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((.(((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..)))))..))..))))...))))....((((((...((....(((.........)))....))))))))......{...((((((..(((((((.((...)).)))))))...((..]])).....)))))))..).(((......((((....))))....)))...]]].](((((.(((((((..(..(((.(..((((((((((......((........))...........((((((..(....(((..(...(((.(.(....).).)))...................).))).).((.(((...((((((......(((((((((....)))...(((......)))...))))))......(((.(((((((...(..............).....))))))).....(((........)))........)))........).)))...)).)))))....))))))....)).)))))))).(...(((((((.....(.(...(..(((......)))..).....).).....)))))))...........((((((..........)))))).......)..).))).....(((((((..........)))))))......)....)))))))))).))....(..((...((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))....))...).....(((((((((....)))))))))}.. The structures of viomycin bound to the 70S ribosome.; 16S ribosomal RNA 4v7l CV 10 3.0 URS000080DEFF_32630 20154709 32630 aaaaugcagu .......... .......... The structures of viomycin bound to the 70S ribosome.; RNA (5'-R(*AP*AP*AP*AP*AP*GP*GP*AP*AP*AP*UP*A*AP*AP*AP*AP*UP*GP*CP*AP*GP*UP*UP*CP*AP*AP*UP*CP*UP*A)-3') 4v7l CW 75 3.0 RF00005 URS00004FF598_536056 20154709 0030533 0006412 536056 ugggguaucgccaagcgguaaggcaccggauucugauuccggcauuccgagguucgaauccucguaccccagcca <<<<<<<..<<<.........>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..(((.....[...))).(((((.......))))).....(((((..]....)))))))))))).... The structures of viomycin bound to the 70S ribosome.; tRNA-Gln 4v7l CX 77 3.0 RF00005 URS000041AF00_536056 20154709 0030533 0006412 536056 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<...<<<<.........>>>>.<<<<<.......>>>>>......<<<<.......>>>>..>>>>>..... .((((((..((((......[..)))).(((((.......))))).....((((...].....))))))))))..... The structures of viomycin bound to the 70S ribosome.; tRNA-Met 4v7l CY 75 3.0 RF00005 URS000080E16B_536056 20154709 0030533 0006412 536056 ugggguaucgccaagcgguaaggcaccggauugugauuccggcuuuccgagguucgaauccucguaccccagcca <<<<<<<..<<<.........>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... ((((.((..((...........)).(.((.........)).).....((((.........)))))).)))).... The structures of viomycin bound to the 70S ribosome.; tRNA-Gln 4v7l DA 2800 3.0 RF02540,RF02541,RF00002 URS00001698E8_300852 20154709 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucgggggcccucggccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccagucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaaaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu 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.........((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((......)))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....((((.((((........((((....((.(((...(((((......)))))[[(...).((......]].))...)))...)).....))))......))))..)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((((((.(.....)))))))))...(.(........).).((((((....(((((.(((((((..(((...(((.....)))...)))...((....))..((((.....)))).))))))).)))))..((.(...((((((.....((((((((((.((((....(((((......)))))....)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((.(...(((...(((.((((.(.((.(((......)))..)))..)))).)))..)).)...).)))))))..)..))))))).))..((.((((.((......)).)))).)).....((........))...((((.(((...((([[[.....((((((.....(.....((..(((((.(......................).))))).))..........]]].)....)))))).)))...)))))))((((((.(.....).))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....(((.((.......)).)))((((....((((..((..(((((((...(.......).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.((...{{....))))))(((...((((((((((.(((.(.((.....))).))).).....)))))))))..)))(.....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((.........))))))))))(...).......((((.((((.].((.........))...((((.((.....(((....))).......)).)))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).)).)))).)..))).)))))))).)))))).....)).[..(((((......].)))))..((((((((..(..........((((.((((((..(((((.(((.(((((.(((((((.(((.((((.(......[...((((............((((((......)))))).................].)))).).)))).))).)))))))...(((((....)))))....))))).)))..)))))....(......[)..((((((..........]))))))([((...(((((((.(.((.(...........).))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....((((((..((..]]]]..)).)))))).....)}......))))..))))))......(((((...((((((...((.......))...))))))....))).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(((((((....))).))))..>......).))))))))[...((((((....((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..].....))))))....(........).....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))....... The structures of viomycin bound to the 70S ribosome.; 23S ribosomal RNA 4v7l DB 118 3.0 RF00001 URS00005F2F4B_300852 20154709 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaaguaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<<....<<<<<<<<.....<<<<<...............>>>..>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>> ..(((((((((....((((((((.....((.(((...(.....)...)))...))...)))))).))(((.......((((((((....)))))))).......))).))))))))). The structures of viomycin bound to the 70S ribosome.; 5S ribosomal RNA 4v7m AA 1495 3.45 RF00177,RF01959,RF01960 URS000080E145_300852 20154709 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccgagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<...........>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<.<<..<<<<<<<....>>>>>>>........>>.>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<....<<.....>>.>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<...<<<<....>>>>...>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<.<...>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((((((...........))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((..(.(...(((.(((....))).)))..........))..))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...(..............).....))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((...(..((((....))))..).....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((..........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....((.(...))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. The structures of Capreomycin bound to the 70S ribosome.; 16S ribosomal RNA 4v7m AV 10 3.45 URS000080DEFF_32630 20154709 32630 aaaaugcagu .......... .......... The structures of Capreomycin bound to the 70S ribosome.; RNA (5'-R(*AP*AP*AP*AP*AP*GP*GP*AP*AP*AP*UP*A*AP*AP*AP*AP*UP*GP*CP*AP*GP*UP*UP*CP*AP*AP*UP*CP*UP*A)-3') 4v7m AW 74 3.45 RF00005 URS00004FF598_536056 20154709 0030533 0006412 536056 gggguaucgccaagcgguaaggcaccggauucugauuccggcauuccgagguucgaauccucguaccccagcca <<<<<<..<<<.........>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((......[....)).(((((.......))))).....(((((..]....)))))))))))..... The structures of Capreomycin bound to the 70S ribosome.; tRNA-Gln 4v7m AX 77 3.45 RF00005 URS00001BBAFC_536056 20154709 0030533 0006412 536056 cgcgggguggagcagccugguagcucgucgggcucauaacccgaagaucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... The structures of Capreomycin bound to the 70S ribosome.; tRNA-Met 4v7m AY 75 3.45 RF00005 URS000080E16B_561231 20154709 0030533 0006412 561231 ugggguaucgccaagcgguaaggcaccggauugugauuccggcuuuccgagguucgaauccucguaccccagcca <<<<<<...<<<.........>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>.>>>>>>.... ((((((.....(.........)...((((.........)))).....((((.........)))).)))))).... The structures of Capreomycin bound to the 70S ribosome.; tRNA-Gln 4v7m BA 2789 3.45 RF02540,RF02541,RF00002 URS00001698E8_300852 20154709 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucgggggcccucggccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccagucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagccaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgagguc 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.........((((((((((.....(((..((((((((((((......((((((.[[.[[[.))).....((((((...(((]]].]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((....))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...((((((((.....))))))))....{(((((((((...(...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)..)))))).))))....(((((((((.[.....)))))))))....}.(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((((((((())))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))..)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((...((.((........))..))...)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((((......................))))))).))..........]]].)....))))))))))...)))))))(((((((())))))))....))))))(((((((...(((......(((((.(((....))))))))...)))..))))).)).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.((...{{....))))))(((...((((((((((..(((..((.....)).)))..).....)))))))))..)))(........))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((((.......)))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((.(.((((.(.........(((((..(((......((((((((....))))))))...)))............)))))).)))).).)))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))...(..).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...... The structures of Capreomycin bound to the 70S ribosome.; 23S ribosomal RNA 4v7m BB 119 3.45 RF00001 URS00005F2F4B_300852 20154709 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))) The structures of Capreomycin bound to the 70S ribosome.; 5S ribosomal RNA 4v7m CA 1493 3.45 RF00177,RF01959,RF01960 URS000080E145_300852 20154709 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgcguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<..<<<<<..>>>>>..>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<..[.>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>.......]..<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<.<<..<<<<<<<....>>>>>>>....<<.....>>....>>.>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<....<<.....>>.>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<...<<<<....>>>>...>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..(.....((....)).....))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...((..(.(...(((((((....)))))))...................))..))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...(..............).....)))))))..(..(((.(....).))).....)..)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((...(..((((....))))..).....))).....)))))))......(....(((((((........)))))))....)..)..))))).....((((.((......]...)).))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. The structures of Capreomycin bound to the 70S ribosome.; 16S ribosomal RNA 4v7m CV 10 3.45 URS000080DEFF_32630 20154709 32630 aaaaugcagu .......... .......... The structures of Capreomycin bound to the 70S ribosome.; RNA (5'-R(*AP*AP*AP*AP*AP*GP*GP*AP*AP*AP*UP*A*AP*AP*AP*AP*UP*GP*CP*AP*GP*UP*UP*CP*AP*AP*UP*CP*UP*A)-3') 4v7m CW 74 3.45 RF00005 URS00004FF598_536056 20154709 0030533 0006412 536056 gggguaucgccaagcgguaaggcaccggauucugauuccggcauuccgagguucgaauccucguaccccagcca <<<<<<..<<<.........>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((......[....)).(((((.......))))).....(((((..]....)))))))))))..... The structures of Capreomycin bound to the 70S ribosome.; tRNA-Gln 4v7m CX 77 3.45 RF00005 URS000041AF00_536056 20154709 0030533 0006412 536056 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... The structures of Capreomycin bound to the 70S ribosome.; RNA (77-MER) 4v7m CY 75 3.45 RF00005 URS000080E16B_561231 20154709 0030533 0006412 561231 ugggguaucgccaagcgguaaggcaccggauugugauuccggcuuuccgagguucgaauccucguaccccagcca <<<<<<<..<<<.........>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((...........)).(.((.........)).)......((((.......)))).))))))).... The structures of Capreomycin bound to the 70S ribosome.; tRNA-Gln 4v7m DA 2775 3.45 RF02540,RF02541,RF00002 URS00001698E8_300852 20154709 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucgggggcccucgccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<..>>>>>>.>>....<<<<<.....<<....>>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>.....<<<<<<<<.<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>.>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<..>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<........>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<...>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<..>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[....>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><.......>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<.<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>.>>>>...<<<<..>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<.......>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> .........((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((....))))).))...((((((.....(...[..)......))))).).........(......)...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(((..((((..((...(((((.(.((.(((...(((((......)))))[[(...).(((.....]])))...)))...)).)..)))))..))..))))...))]....((((((((..[......))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((.((((..)))).))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((.(((...(((...(((.((((...((((((......)))).))...)))).)))..)).)...))).)))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((.((.(...).)).)))).))..........]]].)....))))))))))...)))))))(((((((())))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.((...{{....))))))(((...((((((((((.(((((.((.....))))))).).....)))))))))..)))(.......))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((((.......)))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((..((((.(.((((.(.........(((((..(((......((((((((....))))))))...)))............)))))).)))).).))).).)))...((((()))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))...(.........).....(((((((((.......)))))....((((((((..((....(.(((....))).)...))...))))).)))...))))....... The structures of Capreomycin bound to the 70S ribosome.; 23S ribosomal RNA 4v7m DB 119 3.45 RF00001 URS00005F2F4B_300852 20154709 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<......<<<<<<<<.....<<.<<...............>>...>>....>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>...>>>>>>>> ....(...(.(.....(((((.(....(((..((.............))....)))...).)))).).(.........((..((((....))))..)).........).).)...)... The structures of Capreomycin bound to the 70S ribosome.; 5S ribosomal RNA 4v7p AA 1504 3.62 RF00177,RF01959,RF01960 URS000080E1FC_262724 20588254 0003735 0005840 262724 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgaggaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<...<..<<<.<<<..<<<..<<.<<<<<<<<<<.....>>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>...>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<.<<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<......>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((.(.....).)))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((..((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((((..(((((((....)))))))...((((....))))..))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..((...(((.....)))).)...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))).))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Recognition of the amber stop codon by release factor RF1.; 16S rRNA (1504-MER) 4v7p AW 77 3.62 RF00005 URS000041AF00_469008 20588254 0030533 0006412 469008 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Recognition of the amber stop codon by release factor RF1.; P-site tRNA-fMet 4v7p BA 2879 3.62 RF02540,RF02541,RF00002 URS000080DEC7_262724 20588254 0003735 0005840 262724 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgucuaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaaaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagcuccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagacuacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.....>>>>>>.>>....<<<<<.....<......>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<.<.....(...<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>..........).>>>>>>.>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<<.....>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...).)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((.(.((((((......)))).)))..)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((..(((.........)))..))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.((...{{....))))))(((...((((((((((((((((.((.....)))))))))....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.[..).....)))))((((((((((((.....))))))))))))(...).......(((((((((...((.........))...(((((((.....(((....))).......))))))).]((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((.((((((.(.........(((((..(((......((((((((....))))))))...)))............)))))).)))))).)))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))(.((...(((((((.(.(((((.........)))))...).((.[.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))...(((.....))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Recognition of the amber stop codon by release factor RF1.; 23S ribosomal RNA 4v7p BB 119 3.62 RF00001 URS000080DE2B_262724 20588254 0003735 0005840 262724 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).)))))))))) Recognition of the amber stop codon by release factor RF1.; 5S ribosomal RNA 4v7p CA 2879 3.62 RF02540,RF02541,RF00002 URS000080DEC7_262724 20588254 0003735 0005840 262724 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgucuaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaaaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagcuccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagacuacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.....>>>>>>.>>....<<<<<.....<......>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<.<.....(...<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>..........).>>>>>>.>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<<.....>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...).)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((.(.((((((......)))).)))..)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((..(((.........)))..))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.((...{{....))))))(((...((((((((((((((((.((.....)))))))))....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.[..).....)))))((((((((((((.....))))))))))))(...).......(((((((((...((.........))...(((((((.....(((....))).......))))))).]((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((.((((((.(.........(((((..(((......((((((((....))))))))...)))............)))))).)))))).)))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))(.((...(((((((.(.(((((.........)))))...).((.[.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))...(((.....))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Recognition of the amber stop codon by release factor RF1.; 23S ribosomal RNA 4v7p CB 119 3.62 RF00001 URS000080DE2B_262724 20588254 0003735 0005840 262724 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).)))))))))) Recognition of the amber stop codon by release factor RF1.; 5S ribosomal RNA 4v7p DA 1504 3.62 RF00177,RF01959,RF01960 URS000080E1FC_262724 20588254 0003735 0005840 262724 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgaggaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<...<..<<<.<<<..<<<..<<.<<<<<<<<<<.....>>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>...>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<.<<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<......>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((.(.....).)))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((..((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((((..(((((((....)))))))...((((....))))..))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..((...(((.....)))).)...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))).))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Recognition of the amber stop codon by release factor RF1.; 16S rRNA (1504-MER) 4v7p DW 77 3.62 RF00005 URS000041AF00_469008 20588254 0030533 0006412 469008 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Recognition of the amber stop codon by release factor RF1.; P-site tRNA-fMet 4v7r A1 1789 4.0 RF01960,RF01959,RF00177 URS00005F2C2D_4932 21109664 0003735 0005840 4932 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccgguccgauuuuuuuuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<...{{{{>>>>>{{{...[[[[[................[[[.[[[..<<...<.<.....<<..........>>..>.>>>......{{........[[[..{{..{{....[[[..................<.....<<.<<<.....>>>.>>......>.........<<<<<..<<....>>..>>>>>....((((((.......<<<<<<<<<<<..>>>>..............))))))..........<<<..<<<.....>>>.>>>.....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<<<<<<....>>>>...>>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<<<.<<..<....>..>.>>>>.>>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..]]]]]..}}}.........[[[<<.......{{...[[[.{{....<<<<<<.<<<.<..................>.>>>.>>>>>>.....<<<<.....<...<<<<.......>>>>...>.....>>>>....<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[[.[...((((.....>>>>>>>...))))..].]]].....}}....<<<<<<.<<...<<<<..<<..<<<<<<.....<<<......>>>........>>>>>>..>>......<<<....>>>..>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<<..<<<<<<<.<<<........>>>>>>>>>>...>>>>..<<..>>>>...>>.....>>>.]]].<<<......<<<......>>>....>>>..}}}}..<<<<.<<<<<<<<..<<.<<<<<<..<<<.<<<<........<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<<.<<<<....<<<<<<<<<<....>>>>>.>>.>>>....>>>>>>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>.....>.>>>>>......>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>......<....<<<<<<..........>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<....<......<<.............................>>.....>..>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((....[[[..))))((((..((.((...(.(...((..{..(((.(((..(....(((.....((.(......).))..))).)......(((.......(((..((..((....(((..................(.....((.(((.....))).))......)............((..((....))..))...(.(.((((((......[.[[[[[[(((....))).....(......).)))))).)...).....((...((.....))..))......)))...))))..))).(((....(((....((((((((.......)))))))))))......)))....(((((((....))))...))).))).((.(((..........))).)).(.((....)).)...)))))).)...}.(.(((...((((.....))).))))).)....).).....(.(((((.(.(((....))).).))).)).)......((..(..(......).)..)).........((((([[......((((.....((..]])).......)))).)))))..)).)).))).)........((({{.....(.((...(((.(......(.(((.(.((....................)).).))).).......((...........(((.......)))...........)).......(((.((.......((..............(((.....)))....))......)).))..)...............(.....(......]]]]].]]...)....)..........)...(((.(((..(...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)..)))..))..))))...)).)....((((((....(...((.(.........).))...).))))))......<...(((.((.((((..((.((((.((..........)))))).))...))))..((..}}))...)).....))).)))..((.......(((....))).....))....]]]..(.((..(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((........((.(((........))).))......)))))...((.(((..((.((((((....(((.(((((....)))....((......))....)).)))....(((((.(((.(((...((.((.((((((....))))))...)).))...))))))..(.((((((.....))))))....)..)))))....))).))).....))))))).....).)))))...)).)))).))).(...(((((((......((.....((..(.((....)).)..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....((((((((.......))))))))......))...))))))).))..)..(.(..((.(..((((.((..(.((((((((.(((..(.((..(.......(..............................).......))).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>........ Yeast 80S ribosome.; 18S ribosomal RNA 4v7r B1 3206 4.0 RF02540,RF02543 URS000061F377_559292 21109664 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacauugggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggaacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauagaggguguagaauaagugggagcuucggcgccagugaaauaccacuaccuuuauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<<...<<.<<.<<<<<<...>>>>>>.>>.>>...>>>......<<<<<.<<<<<<..<<<.<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>...>>>..>>....>>>>>>>>>..........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>................<<.....>>....................................<<<<<.<<<<<.<.......<<<<<<.....<<<.<..<<<<<......<<<<<<<<......<<<<<......>>>>>.......>>>>>>>.>...>>>>>..>.>>>............<<<....>>>......>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<..<<<<<.....>>>>>..>>>...<<....>>.........<<<<..<<<<....>>>>..>.>>>...<<<<<<<................>>.>>>.>>....>>>>>>.>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<......<<<....>>><.<<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<.<<.<<<<<<.....>>>>>>>>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>>.<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<...........>>>>>>>>....>>>>>>..<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>.........<<<<<........>>>>>.....>>....>>...<<<<<........>>>>>))<<<<.<<<<....<...<<<....>>>.......<<<<<<...<<<<.<<<<<<<<<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<<....>>>>>>>>>>>>.>.>>>>>>>.>>>>.........>>>>>>..........>....>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>.>>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<.<<<<<<<<<<<...>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>>.<<<<<.......>>>>>.........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<<..<<<<<..........<<<<<..<<<..>>>............>>>>>.>>>>>...>>>>>>>>>>...<<<<<.....<<<<..<<<.<......>.>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<..<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]......<<<<<...<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<.}}}..>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>.....>>>>>.........<<<<<<.<<<.<<................<<<<<.......>>>>>...............<<<<<.<<..<<<<.<..<<<......>>>..>.>>>>>>.>>>>>.............>>.>>>.>>>>>>...<<<<.....................<<<<<<<<..<<....<<<<<....<<<..........>>>...>>>>>...>>....>>>..>>>>>..>>.>>.. ........................((((((.....(...[..)......))))).).........((....))...((((......((.]...)).....))))...((((...(....(.((.((((((...)))))).)).)....).........((((.((((.(..(((.((((((((...({((((......)))))[[(...).(((....}]])))....))))))))...)))..).....))))))))......)....(((((((........)))))))......((((..[[[.[[))))...)))..................................((....))............(..((.(....).))............).....................(((((.(((((.(.......(((((((.(.((((.(..(((((.......(((.(((....(..(((.(....).)))....)...))).))).....)))))..).))).).)........(((....))).....)))))))....)))))).)))))..((((........))))((((((....((((((.((((((..((((..((((.....))))..))))...((....)).........(((...((((....))))....)))...(((.(((....(......)....)).).).))....)))))).))))))..((.(...((((((.....(((((.(((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))).))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)(((((((((....(((.(((((((.....(((.....((..(.(((.(.(...(((.....)))...))))).)..))...)).).....)))))...((((.((((.(......))))).)))).....)))))..))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((.................(((.((((((((((.......(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]]......))))))))))...)))))))((((((((...........))))))))....))))))(.((((((((.((.......(((.((((....)))))))....))))))))))..).....))))))((......(.....((((((.......))))))((((.....((((..((..(((((((...((.....)).))))))....[[(((.((...((....(((....))).........(((((........))))).....))....))...(((((........)))))]]((((.((((.(..(..((((....)))...(...((((((...((((.((((((((((((((((((...{...))))))((..((((.....(((((.....(((.....))).....)))))......))))...))((((((((....)))))))))))).).))))))).))))(...)....))))))...)).....)..).)))))))).))).))).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((.(...).)))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...((.....((((....)))).....)).)))))..))))).((((.........))).)........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))).....)).[..(((((.......])))))....(((((..(((.((......((((.((((((..(((((.((((((((..((.(((.(((..((((........[..(((((..((....))..........].)))))..))))...))).))).))....((((.....((((..(((((......)))))...............((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...(((..((((.......))))..))).(((....))).))]]].].....((((((..((((.]].]]]))))))))))....).....))))..)))))).......((.(.(.((((.(...((.......))...).))))...)).).).......((.((.((((((..(..((((((......))))))....).(((.(.....).))).....)))))..)...))..))....(((((((....))).))))..>.))..))).))))).....((((((...((((...((((((.....(....)....))))))..(((((...((((....((((((((((.}..)))))..)))))...))))..))))).((((...((((.............))))...)))).)))).....))))))........(.((((.(((.((....((.(.........(((((.....)))).)....).)).......((.((.((..(..(.(..(((......)))..).)..))).)).)).............)).))).)))).)...((((.(..(.......)..).....(.((((((..((....(((((....((((........))))...)))))...))....)))..))).)..)).)).. Yeast 80S ribosome.; 25S ribosomal RNA 4v7r B2 121 4.0 RF00001 URS000055688D_4932 21109664 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<.....<<<<<<<<.....<<.<.................>...>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>.>>>>>>>>. (.((((.((....((((((((.....((.......................))....)))))).)).(((((.......(((((..((....)).))))).....))))).)).)))).). Yeast 80S ribosome.; 5S ribosomal RNA 4v7r B3 158 4.0 RF00002 URS00001BF64E_4932 21109664 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<........>>>.....<<.<<......................>>>..>...>>>....<<<...>>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((..[.....))).....(..((.........]............))...)...)))....(((...)))(((((((((....)))))))))..................... Yeast 80S ribosome.; 5.8S ribosomal RNA 4v7r C1 1789 4.0 RF01960,RF01959,RF00177 URS00005F2C2D_4932 21109664 0003735 0005840 4932 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccgguccgauuuuuuuuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<...{{{{>>>>>{{{...[[[[[................[[[.[[[..<<...<.<.....<<..........>>..>.>>>......{{........[[[..{{..{{....[[[..................<.....<<.<<<.....>>>.>>......>.........<<<<<..<<....>>..>>>>>....((((((......<<<<<<<<<<<<..>>>>..............))))))..........<<<..<<<.....>>>.>>>.....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<<<<<<....>>>>...>>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<<<.<<..<....>..>.>>>>.>>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..]]]]]..}}}.........[[[{{.......{{...[[[.{{....<<<<<<.<<<.<..................>.>>>.>>>>>>....<<<<<<....<<..<<<<.......>>>>..>>....>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[[.[...((((.....>>>>>>>>..))))..].]]].....}}....<<<<<<.<<...<<<<..<<..<<<<<<.....<<<......>>>........>>>>>>..>>......<<<....>>>..>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<<..<<<<<<<.<<<........>>>>>>>>>>...>>>>..<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..}}}}...<<<.<<<<<<<<..<<.<<<<<<..<<<.<<<<........<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<<.<<<<....<<<<<<<<<<....>>>>>.>>.>>>....>>>>>>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>.....>.>>>>>......>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>......<....<<<<<<..........>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>.....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<....<......<<.............................>>.....>..>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((....[[[..))))((((.(((.((...(.(...((..{..(((.(((..(....(((.....((.(......).))..))).)......(((.......(((..((..((....(((..................(.....((.(((.....))).))......)............((..((....))..)).....(.((((((......[.[.[[[[(((....))).....(......).)))))).).........((...((.....))..))......)))...))))..))).(((....(((....((((((((.......)))))))))))......)))....(((((((....))))...))).))).((.(((..........))).)).(.((....)).)...)))))).)...}.(.(((...((((.....))).))))).)....).).....(.(((((.(.(((....))).).))).)).)......((..(..(......).)..)).........((((([[......((((.....((..]])).......)))).)))))..)).)))))).)........((({{.....(.((...(((.(......(.(((.(.((....................)).).))).)......(((((....(...((((.......))))...)....)))))......(((.((.......((..............(((.....)))....))......)).))..)...............(.....(......]]]]..]]...)....)..........)...(((.(((..(...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)..)))..))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.((((..((.((((.((..........)))))).))...))))..((..}}))...)).....))).)))..((.......(((....))).....))....]]]..(.((..(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((........((.(((........))).))......)))))...((.(((..((.((((((....(((.(((((....)))....((......))....)).)))....(((((.(((.(((...((.((.((((((....))))))...)).))...))))))..(.((((((.....))))))....)..)))))....))).))).....))))))).....).)))))...)).)))).))).(...(((((((......((.....((..(.((....)).)..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....((((((((.......))))))))......))...))))))).))..)..(.(..((.(..((((.((..(.((((((((.(((..(.((..(.......(..............................).......))).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>........ Yeast 80S ribosome.; 18S ribosomal RNA 4v7r D1 3206 4.0 RF02540,RF02543 URS000061F377_559292 21109664 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacauugggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggaacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauagaggguguagaauaagugggagcuucggcgccagugaaauaccacuaccuuuauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<<...<<.<<.<<<<<<...>>>>>>.>>.>>...>>>......<<<<<.<<<<<<..<<<.<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>...>>>..>>....>>>>>>>>>..........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>................<<.....>>....................................<<<<<.<<<<<.<.......<<<<<<.....<<<.<..<<<<<......<<<<<<<<......<<<<<......>>>>>.......>>>>>>>.>...>>>>>..>.>>>............<<<....>>>......>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<..<<<<<.....>>>>>..>>>...<<....>>.........<<<<..<<<<....>>>>..>.>>>...<<<<<<<................>>.>>>.>>....>>>>>>.>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<......<<<....>>><.<<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<.<<.<<<<<<.....>>>>>>>>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.........>>>>.>>>>.....>>>>>.>>>>>>>>.>>>.<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<...........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........)))..>...>>>>>>.>>>>..>>>>>>><<<<<<<<...........>>>>>>>>....>>>>>>...<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>.........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>.........<<<<<........>>>>>.....>>....>>...<<<<<........>>>>>))<<<<.<<<<....<...<<<....>>>.......<<<<<<...<<<<.<<<<<<<<<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<<....>>>>>>>>>>>>.>.>>>>>>>.>>>>.........>>>>>>..........>....>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>.>>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<...............>>>>><<.<<<<<<<<<<<...>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>>.<<<<<.......>>>>>.........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<<..<<<<<..........<<<<<..<<<..>>>............>>>>>.>>>>>...>>>>>>>>>>...<<<<<.....<<<<..<<<.<......>.>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<..<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]......<<<<<...<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<.}}}..>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>.....>>>>>.........<<<<<<.<<<.<<................<<<<<.......>>>>>...............<<<<<.<<..<<<<.<..<<<......>>>..>.>>>>>>.>>>>>.............>>.>>>.>>>>>>...<<<<.....................<<<<<<<<..<<....<<<<<....<<<..........>>>...>>>>>...>>....>>>..>>>>>..>>.>>.. ........................((((((.....(...[..)......))))).).........((....))...((((......((.]...)).....))))...((((...(....(.((.((((((...)))))).)).)....).........((((.((((.(..(((.((((((((...({((((......)))))[[(...).(((....}]])))....))))))))...)))..).....))))))))......)....(((((((........)))))))......((((..[[[.[[))))...)))..................................((....))............(..((.(....).))............).....................(((((.(((((.(.......(((((((.(.((((.(..(((((.......(((.(((....(..(((.(....).)))....)...))).))).....)))))..).))).).)........(((....))).....)))))))....)))))).)))))..((((........))))((((((....((((((.((((((..((((..((((.....))))..))))...((....)).........(((...((((....))))....)))...(((.(((....(......)....)).).).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)(((((((((....(((.(((((((.....(((.....((..(.(((.(.(...(((.....)))...))))).)..))...)).).....)))))...((((.((((.(......))))).)))).....)))))..))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((.................(((.((((((((((.......(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]]......))))))))))...)))))))((((((((...........))))))))....))))))(.((((((((.((.......(((.((((....)))))))....))))))))))..).....))))))((......(.....((((((.......))))))((((.....((((..((..(((((((...((.....)).))))))....[[(((.((...((....(((....))).........(((((........))))).....))....))...(((((........)))))]]((((.((((.(..(..((((....)))...(...((((((...((((.((((((((((((((((((...{...))))))((..((((.....(((((.....(((.....))).....)))))......))))...))((((((((....)))))))))))).).))))))).))))(...)....))))))...)).....)..).)))))))).))).))).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((.(...).)))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...((.....((((....)))).....)).)))))..))))).((((.........))).)........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))).....)).[..(((((.......])))))....(((((..(((.((......((((.((((((..(((((.((((((((..((.(((.(((..((((........[..(((((..((....))..........].)))))..))))...))).))).))....((((.....((((..(((((......)))))...............((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...(((..((((.......))))..))).(((....))).))]]].].....((((((..((((.]].]]]))))))))))....).....))))..)))))).......((.(.(.((((.(...((.......))...).))))...)).).).......((.((.((((((..(..(((((........)))))....).(((.(.....).))).....)))))..)...))..))....(((((((....))).))))..>.))..))).))))).....((((((...((((...((((((.....(....)....))))))..(((((...((((....((((((((((.}..)))))..)))))...))))..))))).((((...((((.............))))...)))).)))).....))))))........(.((((.(((.((....((.(..........((((.....))))......).)).......((.((.((..(..(.(..(((......)))..).)..))).)).)).............)).))).)))).)...((((.(..(.......)..).....(.((((((..((....(((((....((((........))))...)))))...))....)))..))).)..))).).. Yeast 80S ribosome.; 25S ribosomal RNA 4v7r D2 121 4.0 RF00001 URS000055688D_4932 21109664 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<.....<<<<<<<<.....<<.<.................>...>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>.>>>>>>>>. (.((((.((....((((((((.....((.......................))....)))))).)).(((((.......(((((..((....)).))))).....))))).)).)))).). Yeast 80S ribosome.; 5S ribosomal RNA 4v7r D3 158 4.0 RF00002 URS00001BF64E_4932 21109664 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<........>>>.....<..<<......................>>...>...>>>....<<<...>>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((..[.....)))....((..((.........]............))...).).)))....(((...)))(((((((((....)))))))))..................... Yeast 80S ribosome.; 5.8S ribosomal RNA 4v7s AA 1533 3.2547 RF00177,RF01959,RF01960 URS000080E246_562 20876128 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggauca .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<.<<..>>.>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>...<.<<<<<......<.<<<<<<.<.......>>>.>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((((((((..)))))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(...(((((((.(.......))).)))).)...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))...((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.....]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Crystal structure of the E. coli ribosome bound to telithromycin.; 16S rRNA 4v7s BA 2854 3.2547 RF02540,RF02541 URS000080E25C_562 20876128 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauggaaguguggacgccagucugcauggcuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu 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((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((((((.)))).))...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]]((((((((((.((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...)).....)))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((((.(...(((((((......)))))))..).)))).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Crystal structure of the E. coli ribosome bound to telithromycin.; 23S rRNA 4v7s BB 118 3.2547 RF00001 URS0000366A67_83333 20876128 0003735 0005840 83333 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))). Crystal structure of the E. coli ribosome bound to telithromycin.; 5S rRNA 4v7s CA 1530 3.2547 RF00177,RF01959,RF01960 URS000080E24C_562 20876128 0003735 0005840 562 ugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggauca ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<.<..>.>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<...<....>.>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<.<.......>>>.>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((((((((..)))))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).)......((....))......(((((..((....)))))))..)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(..(.((((((.(.......))).)))).)...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((..(((((((....)))))))...((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..((.......))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(.(..((...(((....)))...))....).).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.....]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Crystal structure of the E. coli ribosome bound to telithromycin.; 16S rRNA 4v7s DA 2841 3.2547 RF02540,RF02541 URS000080E25C_562 20876128 0003735 0005840 562 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<<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<........>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<.......>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<<..<<<.........>>>..>>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.......<<<<<..<<....>>...>>>>>.......>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<..<<<.<<<<<.<<<<<<<<<<<.<<<<.....<<<<<<<......>>>>>>>....>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>...>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<<...>>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.)))......(((((...(((]]]..].))).......)))))....)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((...(((((((((.(...(((...(((.((((.......)))).)))..)).)...).)))))).)))...))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.......(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((..((.(.(((...(((....)))...)))..)))...((.((........)).))]](((((((((((((...((((....((((..(((..((((((((((.....{{{....)))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((((.(...(((((((......)))))))..).)))).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.((((((...))))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Crystal structure of the E. coli ribosome bound to telithromycin.; 23S rRNA 4v7s DB 117 3.2547 RF00001 URS000080DF7E_83333 20876128 0003735 0005840 83333 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggc <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>> (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))) Crystal structure of the E. coli ribosome bound to telithromycin.; 5S rRNA 4v7t AA 1533 3.1942 RF00177,RF01959,RF01960 URS000080E246_562 20876128 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggauca .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<...<<<<<<<<.<<..>>.>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<.<.......>>>.>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<.<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>..>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((((((((..)))))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((.(.......))).)))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))...((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.....]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Crystal structure of the E. coli ribosome bound to chloramphenicol.; 16S rRNA 4v7t BA 2854 3.1942 RF02540,RF02541 URS000080E25C_562 20876128 0003735 0005840 562 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((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((((((.)))).))...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]]((((((((((.((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...)).....)))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((((.(...(((((((......)))))))..).)))).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Crystal structure of the E. coli ribosome bound to chloramphenicol.; 23S rRNA 4v7t BB 118 3.1942 RF00001 URS0000366A67_83333 20876128 0003735 0005840 83333 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))). Crystal structure of the E. coli ribosome bound to chloramphenicol.; 5S rRNA 4v7t CA 1530 3.1942 RF00177,RF01959,RF01960 URS000080E24C_562 20876128 0003735 0005840 562 ugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggauca ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<......>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<...<....>.>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<.<.......>>>.>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((((((((..)))))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....))).....(((((..((....)))))))..)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(..(.((((((.(.......))).)))).)...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((..(((((((....)))))))...((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(.(..((...(((....)))...))....).).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.....]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Crystal structure of the E. coli ribosome bound to chloramphenicol.; 16S rRNA 4v7t DA 2841 3.1942 RF02540,RF02541 URS00004B0F34_562 20876128 0003735 0005840 562 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<<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<........>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<.......>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<<..<<<.........>>>..>>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.......<<<<<..<<....>>...>>>>>.......>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<..<<<.<<<<<.<<<<<<<<<<<.<<<<.....<<<<<<<......>>>>>>>....>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>...>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<.)))..>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<<...>>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. 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Crystal structure of the E. coli ribosome bound to chloramphenicol.; 23S rRNA 4v7t DB 117 3.1942 RF00001 URS000080DF7E_83333 20876128 0003735 0005840 83333 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggc <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>> (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))) Crystal structure of the E. coli ribosome bound to chloramphenicol.; 5S rRNA 4v7u AA 1533 3.1 RF00177,RF01959,RF01960 URS000080E246_562 20876128 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggauca .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<.<<........>>.>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<.......<<<....>>>......>>>>...<.<<<<<......<.<<<<<<.<.......>>>.>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((..(..)..))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(...(((((((.(.......))).)))).)...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))...((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Crystal structure of the E. coli ribosome bound to erythromycin.; 16S rRNA 4v7u BA 2854 3.1 RF02540,RF02541 URS00004B0F34_562 20876128 0003735 0005840 562 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<<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<.>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<.........>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<..<<....>>..>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<..<<....>>...>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<.....<<<<<<<......>>>>>>>....>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((((((.)))).))...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((((.(....).)))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]]((((((((((.((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...)).....)))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((((.(...(.(((((......))))).)..).)))).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Crystal structure of the E. coli ribosome bound to erythromycin.; 23S rRNA 4v7u BB 118 3.1 RF00001 URS0000366A67_83333 20876128 0003735 0005840 83333 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))). Crystal structure of the E. coli ribosome bound to erythromycin.; 5S rRNA 4v7u CA 1530 3.1 RF00177,RF01959,RF01960 URS000080E246_562 20876128 0003735 0005840 562 ugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggauca ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<......>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<...<....>.>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<.<.......>>>.>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((((.(.(..).).)))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((.....((..((((((((.......)))))))))).......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(...((.((((.(.......))).)).).)...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((.(....(((((((...((........))......)))))))....).......((....))..))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.(...(((((..((((((((((......(..........)........(..((((((..(...(((((((..(((((((....)))))))...((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..((.......))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))).)..)).)))))))).(...(((((((.....(.(..((...(((....)))...))....).).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........))))))).......)...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..(.(...)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Crystal structure of the E. coli ribosome bound to erythromycin.; 16S rRNA 4v7u DA 2841 3.1 RF02540,RF02541 URS00004B0F34_562 20876128 0003735 0005840 562 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<<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<.)))..]..>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<......<<...<<<.<<<<.......>>>>.>>>..>>.......>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<.........>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.......<<<<<..<<....>>...>>>>>.......>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<..<<<.<<<<<.<<<<<<<<<<<.<<<<.....<<<<<<........>>>>>>....>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>...>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((.......(((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)).....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((.(.....(...[..)......).))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((...(((((((((.....(((...(((.((((.......)))).)))..)).).....)))))).)))...))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.......(((((.(((...(...........)...))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((.(..((..(((((((...((.....)).))))))....[[(((..((.(.(((...(((....)))...)))..)))...((.((........)).))]](((((((((((((...((((....((((..(((..((((((((((.....{{{....)))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).).)).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((((((((..((((.(...(((((((......)))))))..).))))..))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((....(((...........)))......((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..((.(((((........)))))...)).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(.(((...(((....(((((((((((}}}.))))))..)))))....))).))).)...(((....((((.............))))....))).))))..]....)))))))(.((((((...))))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Crystal structure of the E. coli ribosome bound to erythromycin.; 23S rRNA 4v7u DB 117 3.1 RF00001 URS0000366A67_83333 20876128 0003735 0005840 83333 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggc <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>> (((((((((.......((((((....(((((((...(.....)...))))..)))...))))))....((.......((((((((...)))))))).......))...))))))))) Crystal structure of the E. coli ribosome bound to erythromycin.; 5S rRNA 4v7v AA 1533 3.2891 RF00177,RF01959,RF01960 URS000080E246_562 20876128 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggauca .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<.<<..>>.>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>...<.<<<<<......<.<<<<<<.<.......>>>.>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<....<.<<<<<<.....>>>>>>.>..>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((((((((..)))))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((.(.......))).)))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))...((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.....]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Crystal structure of the E. coli ribosome bound to clindamycin.; 16S rRNA 4v7v BA 2854 3.2891 RF02540,RF02541 URS000080E25C_562 20876128 0003735 0005840 562 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<<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<.>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<.........>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<..<<....>>..>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<.....<<<<<<<......>>>>>>>....>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((((((.)))).))...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]]((((((((((.((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...)).....)))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((((.(...(.(((((......))))).)..).)))).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(((((((....))).))))..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Crystal structure of the E. coli ribosome bound to clindamycin.; 23S rRNA 4v7v BB 118 3.2891 RF00001 URS0000366A67_83333 20876128 0003735 0005840 83333 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))). Crystal structure of the E. coli ribosome bound to clindamycin.; 5S rRNA 4v7v CA 1530 3.2891 RF00177,RF01959,RF01960 URS000080E24C_562 20876128 0003735 0005840 562 ugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggauca ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<<....>>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<...<....>.>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<.<.......>>>.>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>..<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>....>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((((((.(..).)))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....))).....(((((..((....)))))))..)))))))..)).)))))))(((......(..((((((((.......)))))))))........)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(..(.((((((.(.......))).)))).)...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))...((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(.(..((...(((....)))...))....).).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.....]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Crystal structure of the E. coli ribosome bound to clindamycin.; 16S rRNA 4v7v DA 2841 3.2891 RF02540,RF02541 URS000080E25C_562 20876128 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaacaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauggaaguguggacgccagucugcauggcuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<.......>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<<..<<<.........>>>..>>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.......<<<<<..<<....>>...>>>>>.......>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<..<<<.<<<<<.<<<<<<<<<<<.<<<<.....<<<<<<<......>>>>>>>....>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>...>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<<...>>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.)))......(((((...(((]]]..].))).......)))))....)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((...(((((((((.(...(((...(((.((((.......)))).)))..)).)...).)))))).)))...))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.......(((((.(((...((.........))...))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((..((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((.....{{{....)))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...)))).........))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((((.(...(((((((......)))))))..).)))).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.((((((...))))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Crystal structure of the E. coli ribosome bound to clindamycin.; 23S rRNA 4v7v DB 117 3.2891 RF00001 URS000080DF7E_83333 20876128 0003735 0005840 83333 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggc <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>> (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))) Crystal structure of the E. coli ribosome bound to clindamycin.; 5S rRNA 4v7w AA 1504 3.0 RF00177,RF01959,RF01960 URS000080E226_300852 20876130 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<.........>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<.<..<<<<<<<....>>>>>>>...<<<<....>>>>..>.>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<....<<.....>>..>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<<..>>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((.((...........)).)))).)))))......(((......((((((((..((...(((((((.(((((....(((..........))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))...(((......((((....)))).....))).....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...(((((((.....((((((....((........)).......))))))............((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((.....)))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((.(..((((((((((......((........))........(.(((((((..(...(((((......((((((....)))))).....................)))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(.................)...)))))))......((((....)))).........)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..).))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Structure of the Thermus thermophilus ribosome complexed with chloramphenicol.; 16S rRNA 4v7w BA 2725 3.0 RF02540,RF02541,RF00002 URS000080E25D_300852 20876130 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucgggggcccucggccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcgccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccagucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<..>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>.....<<<<<<<<.<.<<...<<<<..<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>...>>>>..>>>.>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<....>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<...<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<.....<<....>>......>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<..................>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>>.............>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<..<..>..>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<.......>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> ((.......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((....))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(((((((((....(...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)...))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((((((((....)))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))..)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((.(..............)..))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((....................)))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.((...{{....))))))(((...((((((((((..(((..((.....)).)))..).....)))))))))..)))(...........))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((.........))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((.(((.(.(.(()).).).))).)))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))...(.........).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...)))).....)) Structure of the Thermus thermophilus ribosome complexed with chloramphenicol.; 23S ribosomal RNA 4v7w BB 119 3.0 RF00001 URS00005F2F4B_300852 20876130 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>> .((((((((((....(((((.((....(((((((...(.....)...))))..)))...)).))).))(((.......((.(((((....))))).)).......))).)))))))))) Structure of the Thermus thermophilus ribosome complexed with chloramphenicol.; 5S ribosomal RNA 4v7w CA 1504 3.0 RF00177,RF01959,RF01960 URS000080E226_300852 20876130 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<.........>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<.<..<<<<<<<....>>>>>>>...<<<<....>>>>..>.>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<....<<.....>>..>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<<..>>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((.((...........)).)))).)))))......(((......((((((((..((...(((((((.(((((....(((..........))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))...(((......((((....)))).....))).....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...(((((((.....((((((....((........)).......))))))............((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((.....)))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((.(..((((((((((......((........))........(.(((((((..(...(((((......((((((....)))))).....................)))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(.................)...)))))))......((((....)))).........)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..).))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Structure of the Thermus thermophilus ribosome complexed with chloramphenicol.; 16S rRNA 4v7w DA 2725 3.0 RF02540,RF02541,RF00002 URS000080E25D_300852 20876130 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucgggggcccucggccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcgccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccagucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<..>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>.....<<<<<<<<.<.<<...<<<<..<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>...>>>>..>>>.>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<....>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<...<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<.....<<....>>......>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<..................>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>>.............>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<..<..>..>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<.......>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> ((.......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((....))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(((((((((....(...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)...))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((((((((....)))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))..)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((.(..............)..))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((....................)))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.((...{{....))))))(((...((((((((((..(((..((.....)).)))..).....)))))))))..)))(...........))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((.........))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((.(((.(.(.(()).).).))).)))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))...(.........).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...)))).....)) Structure of the Thermus thermophilus ribosome complexed with chloramphenicol.; 23S ribosomal RNA 4v7w DB 119 3.0 RF00001 URS00005F2F4B_300852 20876130 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>> .((((((((((....(((((.((....(((((((...(.....)...))))..)))...)).))).))(((.......((.(((((....))))).)).......))).)))))))))) Structure of the Thermus thermophilus ribosome complexed with chloramphenicol.; 5S ribosomal RNA 4v7x AA 1504 3.0 RF00177,RF01959,RF01960 URS000080E226_300852 20876130 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<.........>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<.<...<<<<<<<....>>>>>>>...<<<<....>>>>....>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<....<<.....>>..>....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<...<<<<....>>>>...>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<<..>>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((..(.(........))..)))).)))))......(((......((((((((..((...(((((((.(((((....(((..........))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.(((((((.((......((((.(.....).))))....)).)))))..)))))))))..(((.(((((...((((((((....(((.((....((........)).......)).)))....).......((....)).)))))))..)))))..))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(.(((((((.....))))))).)...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((......(((((......))))).....................)))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(.................)...)))))))..(...(..(....)..)......)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Structure of the Thermus thermophilus ribosome complexed with erythromycin.; 16S rRNA 4v7x BA 2725 3.0 RF02540,RF02541,RF00002 URS000080E25D_300852 20876130 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucgggggcccucggccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcgccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccagucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<..>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>.....<<<<<<<<.<.<<...<<<<..<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>...>>>>..>>>.>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<....>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<...<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<.....<<....>>......>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<..................>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...........>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<.<<..>>.>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<.......>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> .(.......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((....))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(((((((((....(...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)...))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((((((((....)))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))..)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((.(....(....)....)..))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((....................)))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.((...{{....))))))(((...((((((((((..((...((.....))..))..).....)))))))))..)))(...........))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((((.......)))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((.(.(.(()).).).)))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))...(.........).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...)))).....). Structure of the Thermus thermophilus ribosome complexed with erythromycin.; 23S ribosomal RNA 4v7x BB 119 3.0 RF00001 URS00005F2F4B_300852 20876130 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>> .((((((((((....(((((.((....(((((((...(.....)...))))..)))...)).))).))(((.......((.(((((....))))).)).......))).)))))))))) Structure of the Thermus thermophilus ribosome complexed with erythromycin.; 5S ribosomal RNA 4v7x CA 1504 3.0 RF00177,RF01959,RF01960 URS000080E226_300852 20876130 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<.........>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<.<...<<<<<<<....>>>>>>>...<<<<....>>>>....>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<....<<.....>>..>....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<...<<<<....>>>>...>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<<..>>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((..(.(........))..)))).)))))......(((......((((((((..((...(((((((.(((((....(((..........))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.(((((((.((......((((.(.....).))))....)).)))))..)))))))))..(((.(((((...((((((((....(((.((....((........)).......)).)))....).......((....)).)))))))..)))))..))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(.(((((((.....))))))).)...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((......(((((......))))).....................)))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(.................)...)))))))..(...(..(....)..)......)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Structure of the Thermus thermophilus ribosome complexed with erythromycin.; 16S rRNA 4v7x DA 2725 3.0 RF02540,RF02541,RF00002 URS000080E25D_300852 20876130 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucgggggcccucggccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcgccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccagucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<..>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>.....<<<<<<<<.<.<<...<<<<..<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>...>>>>..>>>.>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<....>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<...<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<.....<<....>>......>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<..................>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...........>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<.<<..>>.>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<.......>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> .(.......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((....))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(((((((((....(...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)...))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((((((((....)))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))..)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((.(....(....)....)..))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((....................)))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.((...{{....))))))(((...((((((((((..((...((.....))..))..).....)))))))))..)))(...........))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((((.......)))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((.(.(.(()).).).)))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))...(.........).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...)))).....). Structure of the Thermus thermophilus ribosome complexed with erythromycin.; 23S ribosomal RNA 4v7x DB 119 3.0 RF00001 URS00005F2F4B_300852 20876130 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>> .((((((((((....(((((.((....(((((((...(.....)...))))..)))...)).))).))(((.......((.(((((....))))).)).......))).)))))))))) Structure of the Thermus thermophilus ribosome complexed with erythromycin.; 5S ribosomal RNA 4v7y AA 1504 3.0 RF00177,RF01959,RF01960 URS000080E226_300852 20876130 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<.........>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>....<<<<.<<<<<....>>>>>.>>>>...<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<.<...<<<<<<<....>>>>>>>...<<<<....>>>>....>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<....<<.....>>..>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<<..>>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.((...(((..((.((((..(...........)..)))).)))))......(((......((((((((..((...(((((((.(((((....(((..........))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))....))))).).....(.(((...(((((....)))).))))).)).))))))..(.((......((((....)))).....)).)....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((.((....((........)).......)).)))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((.....)))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((......(((((......))))).....................)))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(.................)...)))))))..(...((((....))))......)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.. Structure of the Thermus thermophilus 70S ribosome complexed with azithromycin.; 16S rRNA 4v7y BA 2725 3.0 RF02540,RF02541,RF00002 URS000080E25D_300852 20876130 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucgggggcccucggccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcgccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccagucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<..>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>.....<<<<<<<<...<<...<<<<..<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>...>>>>..>>..>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<...<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<.....<<....>>......>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<..................>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...........>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<.<<..>>.>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<.......>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> ((.......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((....))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((.((((.....)))).)))....(((((((((....(...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)...))))).)))]....((((((((..[......))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((((((((....)))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))..)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((.(...((....))...)..))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((((((..................))))))))).))..........]]].)....))))))))))...)))))))((((((.........))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.((...{{....))))))(((...((((((((((..((...((.....))..))..).....)))))))))..)))(...........))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((((.......)))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((.(.(.(()).).).)))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.((.((.........)).))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))...((.......)).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...)))).....)) Structure of the Thermus thermophilus 70S ribosome complexed with azithromycin.; 23S ribosomal RNA 4v7y BB 119 3.0 RF00001 URS00005F2F4B_300852 20876130 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>> .((((((((((....(((((.((....(.(((((...(.....)...))))..).)...)).))).))(((.......((.(((((....))))).)).......))).)))))))))) Structure of the Thermus thermophilus 70S ribosome complexed with azithromycin.; 5S ribosomal RNA 4v7y CA 1504 3.0 RF00177,RF01959,RF01960 URS000080E226_300852 20876130 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<.........>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>....<<<<.<<<<<....>>>>>.>>>>...<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<.<...<<<<<<<....>>>>>>>...<<<<....>>>>....>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<....<<.....>>..>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<<..>>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.((...(((..((.((((..(...........)..)))).)))))......(((......((((((((..((...(((((((.(((((....(((..........))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))....))))).).....(.(((...(((((....)))).))))).)).))))))..(.((......((((....)))).....)).)....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((.((....((........)).......)).)))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((.....)))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((......(((((......))))).....................)))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(.................)...)))))))..(...((((....))))......)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.. Structure of the Thermus thermophilus 70S ribosome complexed with azithromycin.; 16S rRNA 4v7y DA 2725 3.0 RF02540,RF02541,RF00002 URS000080E25D_300852 20876130 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucgggggcccucggccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcgccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccagucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<..>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>.....<<<<<<<<...<<...<<<<..<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>...>>>>..>>..>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<...<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<.....<<....>>......>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<..................>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...........>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<.<<..>>.>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<.......>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> ((.......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((....))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((.((((.....)))).)))....(((((((((....(...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)...))))).)))]....((((((((..[......))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((((((((....)))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))..)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((.(...((....))...)..))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((((((..................))))))))).))..........]]].)....))))))))))...)))))))((((((.........))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.((...{{....))))))(((...((((((((((..((...((.....))..))..).....)))))))))..)))(...........))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((((.......)))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((.(.(.(()).).).)))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.((.((.........)).))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))...((.......)).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...)))).....)) Structure of the Thermus thermophilus 70S ribosome complexed with azithromycin.; 23S ribosomal RNA 4v7y DB 119 3.0 RF00001 URS00005F2F4B_300852 20876130 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>> .((((((((((....(((((.((....(.(((((...(.....)...))))..).)...)).))).))(((.......((.(((((....))))).)).......))).)))))))))) Structure of the Thermus thermophilus 70S ribosome complexed with azithromycin.; 5S ribosomal RNA 4v7z AA 1504 3.1 RF00177,RF01959,RF01960 URS000080E226_300852 20876130 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<.........>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<.<...<<<<<<<....>>>>>>>...<<<<....>>>>....>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<....<<.....>>..>....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<<..>>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((..(...........)..)))).)))))......(((......((((((((..((...(((((((.((.((....(((..(....)..))).....)).))....((((..(.((....)).)..))))...(((.....))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......(((......))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((....((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..)))....))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((.((...)).)))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((.(..((((((((((......((........))...........((((((..(...(((((......((((((....)))))).....................)))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(.................)...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....))))))...[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..).))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.. Structure of the Thermus thermophilus 70S ribosome complexed with telithromycin.; 16S rRNA 4v7z BA 2725 3.1 RF02540,RF02541,RF00002 URS000080E25D_300852 20876130 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucgggggcccucggccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcgccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccagucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>.....<<<<<<<<.<.<<...<<<<..<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>...>>>>..>>>.>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<....>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<...<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<.....<<....>>......>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<..................>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<.<<<<<<.<<.....>>>>>>>>......>>>>>>>>>..>>>.............>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<..<..>..>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<.<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>..>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<.......>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> .(.......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((....))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((((((.......)))))))....(((((((((....(...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)...))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((((((((....)))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))..)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((.(....(....)....)..))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((.(....................).)))))).))..........]]].)....))))))))))...)))))))(((((((.......)))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.((...{{....))))))(((...((((((((.(..((...((.....))..))..)......))))))))..)))(...........))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((.........))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((.((.((.(.(()).).)).)).)))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(.(((.........))).)...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((...............))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))...................(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...)))).....). Structure of the Thermus thermophilus 70S ribosome complexed with telithromycin.; 23S ribosomal RNA 4v7z BB 119 3.1 RF00001 URS00005F2F4B_300852 20876130 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<<....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>> .((((((((((....(.(((.((....(((((((.............))))..)))...)).)))..)(((.......((.(((((....))))).)).......))).)))))))))) Structure of the Thermus thermophilus 70S ribosome complexed with telithromycin.; 5S ribosomal RNA 4v7z CA 1504 3.1 RF00177,RF01959,RF01960 URS000080E226_300852 20876130 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<.........>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]..<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<.<...<<<<<<<....>>>>>>>...<<<<....>>>>....>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<....<<.....>>..>....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.......<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<<..>>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((..(...........)..)))).)))))......(((......((((((((..((...(((((((.((.((....(((..(....)..))).....)).))....((((..(.((....)).)..))))...(((.....))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((.(.........)))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......(((......))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((....((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..)))....))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((.((...)).)))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].]..(((.(((((((.((..(((.(..((((((((((......((........))...........((((((..(...(((((......((((((....)))))).....................)))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(.................)...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....))))))...[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((.(........).)))))....)..)..).))).....(((((((......]...)))))))......))...)))))))))).....(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.. Structure of the Thermus thermophilus 70S ribosome complexed with telithromycin.; 16S rRNA 4v7z DA 2725 3.1 RF02540,RF02541,RF00002 URS000080E25D_300852 20876130 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucgggggcccucggccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcgccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccagucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>.....<<<<<<<<.<.<<...<<<<..<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>...>>>>..>>>.>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<....>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<...<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<.....<<....>>......>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<..................>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<.<<<<<<.<<.....>>>>>>>>......>>>>>>>>>..>>>.............>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<..<..>..>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<.<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>..>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<.......>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> .(.......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((....))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((((((.......)))))))....(((((((((....(...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)...))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((((((((....)))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))..)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((.(....(....)....)..))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((.(....................).)))))).))..........]]].)....))))))))))...)))))))(((((((.......)))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((.(((((...((((....(((((.(((..(((((.((((.((...{{....))))))(((...((((((((.(..(((..((.....)).)))..)......))))))))..)))(...........))))))...)))..)))))(..).....))))...))...))).))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((.........))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((.((.((.(.(()).).)).)).)))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(.(((.........))).)...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((...............))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))...................(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...)))).....). Structure of the Thermus thermophilus 70S ribosome complexed with telithromycin.; 23S ribosomal RNA 4v7z DB 119 3.1 RF00001 URS00005F2F4B_300852 20876130 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<<....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>> .((((((((((....(.(((.......(((((((.............))))..)))......)))..)(((.......((.(((((....))))).)).......))).)))))))))) Structure of the Thermus thermophilus 70S ribosome complexed with telithromycin.; 5S ribosomal RNA 4v83 AA 1506 3.5 RF00177,RF01959,RF01960 URS000080DD36_262724 21245352 0003735 0005840 262724 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgaggaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggauc ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<...<..<<<.<<<..<<<..<<..<<<<<<<<<<...>>>>>>>>>>..>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>...>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<.<<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<.<..<<<<<<<.<..<<<......>>>.....>.>>>>>>>...>.......<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<<....>>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<...<<<.....>>>.>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<<..>>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>..... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.....)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((((..(((((((....)))))))...((((....))))..))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..((...(((.....)))).)...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of a complex containing domain 3 from the PSIV IGR IRES RNA bound to the 70S ribosome.; ribosomal RNA 16S 4v83 AV 35 3.5 URS000080DE81_262724 21245352 262724 ucgcucaaacauuaagugguguugugcgacacuua .<<<.<.<<<<<.(((((>>>>>>.>>>.))))). ((((.(.(((((.[[[[[)))))).))))]]]]]. Crystal structure of a complex containing domain 3 from the PSIV IGR IRES RNA bound to the 70S ribosome.; domain 3 of PSIC IGR IRES RNA 4v83 BA 2760 3.5 RF02540,RF02541,RF00002 URS000080DEC7_262724 21245352 0003735 0005840 262724 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgucuaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggcuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaaaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagcuccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagacuacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu .<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.....>>>>>>.>>....<<<<<.....<<....>>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<.<<<<<<..>>>>>>.>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<<..<<.......>>>..>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<<.....>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>. (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((.(.((.(((......)))..)))..))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.((...{{....))))))(((...((((((((((((((((.((.....)))))))))....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((.(((((()))))).)))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....((((((..((..]]]]..)).)))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))...(((.....))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of a complex containing domain 3 from the PSIV IGR IRES RNA bound to the 70S ribosome.; 23S ribosomal RNA 4v83 BB 119 3.5 RF00001 URS000080DE2B_262724 21245352 0003735 0005840 262724 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).)))))))))) Crystal structure of a complex containing domain 3 from the PSIV IGR IRES RNA bound to the 70S ribosome.; 5S ribosomal RNA 4v83 CA 1506 3.5 RF00177,RF01959,RF01960 URS000080DD36_262724 21245352 0003735 0005840 262724 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgaggaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggauc ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<...<..<<<.<<<..<<<..<<..<<<<<<<<<<...>>>>>>>>>>..>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>...>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<.<<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<.<..<<<<<<<.<..<<<......>>>.....>.>>>>>>>...>.......<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<......>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<...<<<.....>>>.>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<<..>>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>..... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.....)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((((..(((((((....)))))))...((((....))))..))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..((...(((.....)))).)...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of a complex containing domain 3 from the PSIV IGR IRES RNA bound to the 70S ribosome.; ribosomal RNA 16S 4v83 CV 35 3.5 URS000080DE81_262724 21245352 262724 ucgcucaaacauuaagugguguugugcgacacuua .<<<.<.<<<<<.(((((>>>>>>.>>>.))))). ((((.(.(((((.[[[[[)))))).))))]]]]]. Crystal structure of a complex containing domain 3 from the PSIV IGR IRES RNA bound to the 70S ribosome.; domain 3 of PSIC IGR IRES RNA 4v83 DA 2760 3.5 RF02540,RF02541,RF00002 URS000080DEC7_262724 21245352 0003735 0005840 262724 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgucuaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggcuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaaaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagcuccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagacuacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu .<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.....>>>>>>.>>....<<<<<.....<<....>>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<.<<<<<<..>>>>>>.>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<<..<<.......>>>..>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<<.....>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>. (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((.(.((.(((......)))..)))..))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.((...{{....))))))(((...((((((((((((((((.((.....)))))))))....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((.(((((()))))).)))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....((((((..((..]]]]..)).)))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))...(((.....))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of a complex containing domain 3 from the PSIV IGR IRES RNA bound to the 70S ribosome.; 23S ribosomal RNA 4v83 DB 119 3.5 RF00001 URS000080DE2B_262724 21245352 0003735 0005840 262724 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).)))))))))) Crystal structure of a complex containing domain 3 from the PSIV IGR IRES RNA bound to the 70S ribosome.; 5S ribosomal RNA 4v84 AA 1506 3.4 RF00177,RF01959,RF01960 URS000080DD36_262724 21245352 0003735 0005840 262724 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgaggaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggauc ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<...<..<<<.<<<..<<<..<<..<<<<<<.<<......>>>>>>>>..>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>...>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<.<..<<<<<<<.<..<<<......>>>.....>.>>>>>>>...>.......<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<........<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<<....>>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<...<<<.....>>>>.>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>......>>>>>>>>.....<<<<<<<.....<<<..<.<.<<<<....>>>>..>>....>>>.....>>>>>>>.........<.<<<<<<<........>>>>>>>>.........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<<..>>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((.((((.........)))).))).)))))......(((......((((((((..((...(((((((..((((....((((((....)))))).....)))).....((((..((((....))))..))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...((((......))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((..((((((.((..(((((..((((.(((((......((........))..........(.(((((..(...(((.((((..((((((......))))))...((((....))))..)))).)))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(.((((...(....(((.....)))..)....)))).)..(..(((((....))))).....)..)))).....).).)))...)).)))))....))))).)..[)).))).)))).(...(((((((.....(((..(...((((....))))...)....))).....)))))))......(....(((((((........)))))))....)..)..)))))......((((((......]...)))))).......))...)))))).))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of a complex containing domain 3 of CrPV IGR IRES RNA bound to the 70S ribosome.; ribosomal RNA 16S 4v84 AV 34 3.4 URS000080E1E7_262724 21245352 262724 gguuauucagauuagguagucgaaugaccuaccu .<<<<<<<.<<<.(((((>>>>>>>>>>.))))) ((((((((.(((.[[[[[)))))))))))]]]]] Crystal structure of a complex containing domain 3 of CrPV IGR IRES RNA bound to the 70S ribosome.; RNA (34-MER) 4v84 BA 2760 3.4 RF02540,RF02541,RF00002 URS000080DEC7_262724 21245352 0003735 0005840 262724 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgucuaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggcuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaaaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagcuccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagacuacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....[[..[[<<<<<<[[<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.....>>>>>>.>>....<<<<<.....<<....>>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...(((....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>.]]...............<<....>>....]].........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..((((...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>....>>>>>>>>>..>>>....<<<<....>>>>......>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.(((.........<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<.<<<<<<..>>>>>>.>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<.(((..>>>>..)))>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))))>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....((((((((..[......))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((.(.((((((......)))).)))..)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.((...{{....))))))(((...(((.(((((((((.((.((.....)))).))))....))))).)))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((.((((((((())))))))).))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((]..[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].......((((((..((..]]]]..)).)))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))...(((.....))).....(((((((((.......)))))....((((((((..((.....((((....))))....))...))))).)))...))))....))) Crystal structure of a complex containing domain 3 of CrPV IGR IRES RNA bound to the 70S ribosome.; 23S ribosomal RNA 4v84 BB 119 3.4 RF00001 URS000080DE2B_262724 21245352 0003735 0005840 262724 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>> .((((((((((....((((((((....(((((((.............))))..)))...)))))).))(((.......((.((((.(...))))).)).......))).)))))))))) Crystal structure of a complex containing domain 3 of CrPV IGR IRES RNA bound to the 70S ribosome.; 5S ribosomal RNA 4v84 CA 1506 3.4 RF00177,RF01959,RF01960 URS000080DD36_262724 21245352 0003735 0005840 262724 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgaggaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggauc ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<...<..<<<.<<<..<<<..<<..<<<<<<.<<......>>>>>>>>..>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>...>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<........<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<......>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<...<<<.....>>>>.>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>......>>>>>>>>.....<<<<<<<.....<<<..<.<.<<<<....>>>>..>>....>>>.....>>>>>>>.........<.<<<<<<<........>>>>>>>>.........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<<..>>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((.((((.........)))).))).)))))......(((......((((((((..((...(((((((..((((....((((((....)))))).....)))).....((((..((((....))))..))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((........)).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((..((((((.((..(((((..((((((((((......((........))..........(.(((((..(...(((.((((..((((((......))))))...((((....))))..)))).)))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(.((((...(....(((.....)))..)....)))).)..(..(((((....))))).....)..)))).....).).)))...)).)))))....))))).)..[)).)))))))).(...(((((((.....(((..(...((((....))))...)....))).....)))))))......(....(((((((........)))))))....)..)..)))))......((((((......]...)))))).......))...)))))).))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of a complex containing domain 3 of CrPV IGR IRES RNA bound to the 70S ribosome.; ribosomal RNA 16S 4v84 CV 34 3.4 URS000080E1E7_262724 21245352 262724 gguuauucagauuagguagucgaaugaccuaccu .<<<<<<<.<<<.(((((>>>>>>>>>>.))))) ((((((((.(((.[[[[[)))))))))))]]]]] Crystal structure of a complex containing domain 3 of CrPV IGR IRES RNA bound to the 70S ribosome.; RNA (34-MER) 4v84 DA 2760 3.4 RF02540,RF02541,RF00002 URS000080DEC7_262724 21245352 0003735 0005840 262724 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgucuaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggcuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaaaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagcuccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagacuacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....[[..[[<<<<<<[[<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.....>>>>>>.>>....<<<<<.....<<....>>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...(((....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>.]]...............<<....>>....]].........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..((((...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>....>>>>>>>>>..>>>....<<<<....>>>>......>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.(((.........<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<.<<<<<<..>>>>>>.>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<.(((..>>>>..)))>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))))>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((......(...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)..)))))).)))]....((((((((..[......))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((.(.((((((......)))).)))..)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.((...{{....))))))(((...(((.((((((((((((.((.....)))))))))....))))).)))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((.((((((((())))))))).))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((]..[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].......((((((..((..]]]]..)).)))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))...((.......)).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of a complex containing domain 3 of CrPV IGR IRES RNA bound to the 70S ribosome.; 23S ribosomal RNA 4v84 DB 119 3.4 RF00001 URS000080DE2B_262724 21245352 0003735 0005840 262724 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>> .((((((((((....((((((((....(((((((.............))))..)))...)))))).))(((.......((.((((.(...))))).)).......))).)))))))))) Crystal structure of a complex containing domain 3 of CrPV IGR IRES RNA bound to the 70S ribosome.; 5S ribosomal RNA 4v85 AA 1532 3.2 RF00177,RF01959,RF01960 URS000080E246_32630 22187675 0003735 0005840 32630 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggauc .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<.<....>.>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<.<.......>>>.>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((((((((..)))))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((.(((..(......))).))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(..(.((((((.(.......))).)))).)...)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((......(.(((((..(((((((....)))))))...((....))..)))))..)..((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((...((.....)).))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Crystal Structure of Release Factor RF3 Trapped in the GTP State on a Rotated Conformation of the Ribosome.; 16S rRNA 4v85 BA 2853 3.2 RF02540,RF02541 URS000080E25C_562 22187675 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaaggggguccuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauggaaguguggacgccagucugcauggcuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<..<<..>>...>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<.........>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<.<<....>>.>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>>.<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>.<..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.......<<<<<..<<....>>...>>>>>.......>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<..<<<<.....<<<<............>>>>....>>>>..>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ..((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((((..))).))...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..(((((((((((....{{{...))))))((..((((...(((((.((((((.((.....)))))))).)..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((((.(...((................))..).)))).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).)))))))... Crystal Structure of Release Factor RF3 Trapped in the GTP State on a Rotated Conformation of the Ribosome.; 23S rRNA 4v85 BB 118 3.2 RF00001 URS0000366A67_562 22187675 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))). Crystal Structure of Release Factor RF3 Trapped in the GTP State on a Rotated Conformation of the Ribosome.; 5S ribosomal RNA 4v87 AA 2912 3.1 RF02540,RF02541,RF00002 URS000080E23D_300852 22437501 0003735 0005840 300852 ggucaagaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaacggcccgcacgcgggccgaaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggauguuggcuuagaagcagccaucauuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucuugacc <<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.....>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....<<<<<<......>>>>>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<<..<<.......>>>..>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>>> ((((((((......((((((((((.....(((..((((((((((((......((((((.[[..[[[)))...].((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((((((((..).))))))))....(.(((((((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....(((((........)))))....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((...((.(((......)))..))...))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......(((((.(((..(((.........)))..))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........(((((..(((......((((((((....))))))))...)))............)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.((((.....))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...))))))))) Crystal structure analysis of ribosomal decoding.; RNA (2909-MER) 4v87 AB 122 3.1 RF00001 URS00005AB4A7_300852 22437501 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga ..<<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> ..(((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).))))))))))) Crystal structure analysis of ribosomal decoding.; 5S RIBOSOMAL RNA 4v87 BA 1506 3.1 RF00177,RF01959,RF01960 URS000080DEDF_300852 22437501 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggauc ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<.<<...>>.>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<<....>>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(.((((((.((...)).)))))).).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(.(((....))).).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((((..(((.(((....))).)))...((((....))))..))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..((.(((((....))))).)...)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure analysis of ribosomal decoding.; 16S ribosomal RNA 4v87 BB 87 3.1 RF00005 URS00004630EA_32630 22437501 0030533 0006412 32630 gccgaggugguggaauugguagacacgcuaccuugaggugguagugcccaauagggcuuacggguucaagucccguccucgguacca <<<<<<<..<<<...........>>><<<<<<.......>>>>>><<<<....>>>>..<<<<<.......>>>>>>>>>>>>.... ..(((((..((.............)).(((((.......))))).(.((.....)))..(((((.......))))))))))...... Crystal structure analysis of ribosomal decoding.; TRNA-LEU 4v87 BC 77 3.1 RF00005 URS000057545F_1110693 22437501 0030533 0006412 1110693 cgcgggguggagcagcccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure analysis of ribosomal decoding.; TRNA-FMET 4v87 BD 77 3.1 RF00005 URS000057545F_1110693 22437501 0030533 0006412 1110693 cgcgggguggagcagcccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<.<..<<<<.........>>>>.<<<<<.......>>>>>......<<<<.......>>>>..>>>>>..... .((..(...(.(...........).).((((.........))).)....(((((.......))))).)..))..... Crystal structure analysis of ribosomal decoding.; TRNA-FMET 4v87 B1 10 3.1 22437501 32630 uuuaugcucu .......... .......... Crystal structure analysis of ribosomal decoding.; MRNA 4v87 CA 1506 3.1 RF00177,RF01959,RF01960 URS000080DEDF_300852 22437501 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggauc ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<.......>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<<....>>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((((((((((...))))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((((..(((((((....))))))).(.((((....)))).)))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((.......(((.....)))......)))))))...(.(((((....))))).)......)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((..........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure analysis of ribosomal decoding.; 16S ribosomal RNA 4v87 CB 87 3.1 RF00005 URS00004630EA_32630 22437501 0030533 0006412 32630 gccgaggugguggaauugguagacacgcuaccuugaggugguagugcccaauagggcuuacggguucaagucccguccucgguacca <<<<<<<..<<<...........>>><<<<<<.......>>>>>><<<<....>>>>..<<<<<.......>>>>>>>>>>>>.... .(....(..(((...........))).(.(((.......))).).((........))..(((((.......))))))....)..... Crystal structure analysis of ribosomal decoding.; TRNA-LEU 4v87 CC 77 3.1 RF00005 URS000057545F_1110693 22437501 0030533 0006412 1110693 cgcgggguggagcagcccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure analysis of ribosomal decoding.; TRNA-FMET 4v87 CD 77 3.1 RF00005 URS000057545F_1110693 22437501 0030533 0006412 1110693 cgcgggguggagcagcccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<.<<<..<<<<.........>>>>.<<<<<.......>>>>>......<<<.........>>>.>.>>>>..... .((..(...(.(...........).).((((.........))))......((((.......))))..)..))..... Crystal structure analysis of ribosomal decoding.; TRNA-FMET 4v87 C1 10 3.1 22437501 32630 uuuaugcucu .......... .......... Crystal structure analysis of ribosomal decoding.; MRNA 4v87 DA 2907 3.1 RF02540,RF02541,RF00002 URS000080E23D_300852 22437501 0003735 0005840 300852 ggucaagaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaacggcccgcacgcgggccgaaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggauguuggcuuagaagcagccaucauuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucuugacc <<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>....<<<<<.....<......>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....<<<<<<......>>>>>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<........>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<<..>>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>......>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>>> ((((((((......((((((((((.....(((..((((((((((((......((((((.[[..[[[)))...].((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((((((((..).))))))))....(.(((((((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....((((((......))))))....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((...((...(......)....))...))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......(((((.(((..((((.......))))..))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........(((((..(((......((((((((....))))))))...)))............)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.((((.....))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...))))))))) Crystal structure analysis of ribosomal decoding.; RNA (2909-MER) 4v87 DB 122 3.1 RF00001 URS00005AB4A7_300852 22437501 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga ..<<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>>> ..((((((((.((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).)).)))))))) Crystal structure analysis of ribosomal decoding.; 5S RIBOSOMAL RNA 4v88 A2 1781 3.0 RF01960,RF01959,RF00177 URS000080DE56_4932 22096102 0003735 0005840 4932 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagannnnnnnnnnnnnnucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucau ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[..................<.....<<.<<<.....>>>.>>......>.........<<<<<..<......>..>>>>>[...((((((......<<<<<<<<<<<....>>>..............)))))).....]...<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<.<<.<<........>>.>>.>>.>>>......<<..<...........>..>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..))))))]]]].........[[[{{.......{{...[[[.[[....<<<<<<.<<<<<....<.>.....>>>>>.>>>>>>....<<<<<<...........<.......>...........>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[...((((((((....>>>>>>>>.))))))))..]].....]]....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<<<......>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>>....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<......<<<<<<<.<<..................>>.>>>>>>>......>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>....... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[[[[[[[(((....))).....(......).)))))).)...).(.((((..((.......)).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....((..(.(((............))).)...))......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((((.....().....))))).))))))....((((((...............................))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(......((.(((....]]]]]]]].))).)).....).....))...(((..((..(...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)..))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...((.((((.(....................).)))).))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>...... The structure of the eukaryotic ribosome at 3.0 A resolution.; 18S RIBOSOMAL RNA 4v88 A1 3149 3.0 RF02540,RF02543 URS000061F377_4932 22096102 0003735 0005840 4932 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The structure of the eukaryotic ribosome at 3.0 A resolution.; 25S rRNA 4v88 A3 121 3.0 RF00001 URS000055688D_4932 22096102 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). The structure of the eukaryotic ribosome at 3.0 A resolution.; 5S rRNA 4v88 A4 158 3.0 RF00002 URS00001BF64E_4932 22096102 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((...(.]].)..........).)))..)...)))....((.....))(((((((((....)))))))))..................... The structure of the eukaryotic ribosome at 3.0 A resolution.; 5.8S rRNA 4v88 A6 1795 3.0 RF01960,RF01959,RF00177 URS000080E2AF_4932 22096102 0003735 0005840 4932 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The structure of the eukaryotic ribosome at 3.0 A resolution.; 18S rRNA 4v88 A5 3150 3.0 RF02540,RF02543 URS000061F377_4932 22096102 0003735 0005840 4932 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........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((..((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))......)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((...........(((((((((((((((((((((((.......(((((((......((((((....)))))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.(((((..(.((((.....)))).)))))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.......(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((..((((((....((.....))..)))))....[[(((.((...((....(((....)))........(.(....(...).....).)....))....))...(((((........)))))]]((((..(((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).))).))).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((..)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...(......((((....))))......).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(..(............)..)....((((.....((((..(((((......)))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.............))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. The structure of the eukaryotic ribosome at 3.0 A resolution.; 25S rRNA 4v88 A7 121 3.0 RF00001 URS000055688D_4932 22096102 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). The structure of the eukaryotic ribosome at 3.0 A resolution.; 5S rRNA 4v88 A8 158 3.0 RF00002 URS00001BF64E_4932 22096102 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... The structure of the eukaryotic ribosome at 3.0 A resolution.; 5.8S rRNA 4v89 AA 1532 3.7 RF00177,RF01959,RF01960 URS000080E246_562 22187675 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggauc .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<.<....>.>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<.<.......>>>.>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<..<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>.........>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((((((((..)))))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((.(((..(......))).))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(..(.((((((.(.......))).)))).)...)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((......(((((((..(((((((....)))))))...((....))..))))).))..((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((...((.....)).))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Crystal Structure of Release Factor RF3 Trapped in the GTP State on a Rotated Conformation of the Ribosome (without viomycin); 16S rRNA 4v89 BA 2853 3.7 RF02540,RF02541 URS000080E25C_562 22187675 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaaggggguccuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauggaaguguggacgccagucugcauggcuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<...<<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>>.<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<..<<..>>...>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<.........>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<.<<....>>.>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.......<<<<<<.<<....>>..>>>>>>.......>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<..<<<<.....<<<<............>>>>....>>>>..>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(..((..))...)...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((.((....)).))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...(((((.((((((.((.....)))))))).)..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((.(.(...((................))..).).)).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Crystal Structure of Release Factor RF3 Trapped in the GTP State on a Rotated Conformation of the Ribosome (without viomycin); 23S rRNA 4v89 BB 118 3.7 RF00001 URS0000366A67_562 22187675 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))). Crystal Structure of Release Factor RF3 Trapped in the GTP State on a Rotated Conformation of the Ribosome (without viomycin); 5S rRNA 4v8a AA 2827 3.2 RF02540,RF02541,RF00002 URS000080DF8C_300852 22240456 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucggggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgggccgcggcccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagcagucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgagucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<...>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<<<<<<..>>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<...>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<.<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>..>....<<<<<<<....>>>>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>...>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((((((((..).))))))))....(.(((((((((..(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((...))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....(((((((())))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((.(.((((((......)))).)))..)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((...............)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...(((((((((((((((..((.....)).)))))).....)))))))))..)))(...(.(()).).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((.((((((((.(.........(((((..(((......((((((((....))))))))...)))............)))))).)))))))).)))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....)))))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))...(((.))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...))) The structure of thermorubin in complex with the 70S ribosome from Thermus thermophilus.; 23S ribosomal RNA 4v8a AB 120 3.2 RF00001 URS000080E019_300852 22240456 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcgggggg .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>. .((((((((((....((((((((....(((((.....(.....).....))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). The structure of thermorubin in complex with the 70S ribosome from Thermus thermophilus.; 5S ribosomal RNA 4v8a BA 2827 3.2 RF02540,RF02541,RF00002 URS000080DF8C_300852 22240456 0003735 0005840 300852 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The structure of thermorubin in complex with the 70S ribosome from Thermus thermophilus.; 23S ribosomal RNA 4v8a BB 120 3.2 RF00001 URS000080E019_300852 22240456 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcgggggg .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>. .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). The structure of thermorubin in complex with the 70S ribosome from Thermus thermophilus.; 5S ribosomal RNA 4v8a CA 1498 3.2 RF00177,RF01959,RF01960 URS000080DFD7_300852 22240456 0003735 0005840 300852 guuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggcccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugg ......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>.....<......>....>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>.........<.<<<<<<<........>>>>>>>>.........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.. ......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((())))))))).)))))......(((......((((((((..((...(((((((.(((((.....(((((....)))))......)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))...(((......((((....)))).....)))......((((...(....((((.....)))).....)....)))).......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((.(((....))).)))...((((....))))...)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..((...(((.....)))).)...))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}. The structure of thermorubin in complex with the 70S ribosome from Thermus thermophilus.; 16S ribosomal RNA 4v8a DA 1498 3.2 RF00177,RF01959,RF01960 URS000080DFD7_300852 22240456 0003735 0005840 300852 guuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggcccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugg ......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>.....<......>....>>>>>>>>..<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>....>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>.........<.<<<<<<<........>>>>>>>>.........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.. ......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((.(((()))).)))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((.(((....))).)))...((((....))))...)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..((...(((.....)))).)...))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}. The structure of thermorubin in complex with the 70S ribosome from Thermus thermophilus.; 16S ribosomal RNA 4v8b AA 1506 3.0 RF00177,RF01959,RF01960 URS000080DEDF_300852 22437501 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggauc ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<<<...>>>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<<....>>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(.((((((.((...)).)))))).).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(.(((....))).).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((((..(((((((....)))))))...((((....))))..))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure analysis of ribosomal decoding (near-cognate tRNA-leu complex).; 16S ribosomal RNA 4v8b AB 87 3.0 RF00005 URS00004630EA_1110693 22437501 0030533 0006412 1110693 gccgaggugguggaauugguagacacgcuaccuugaggugguagugcccaauagggcuuacggguucaagucccguccucgguacca <<<<<<<..<<<...........>>><<<<<<.......>>>>>><<<......>>>..<<<<<.......>>>>>>>>>>>>.... .((((((..((.............)).(((((.......))))).((.(.....)))..(((((.......)))))))))))..... Crystal structure analysis of ribosomal decoding (near-cognate tRNA-leu complex).; TRNA-LEU 4v8b AC 77 3.0 RF00005 URS000057545F_1110693 22437501 0030533 0006412 1110693 cgcgggguggagcagcccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure analysis of ribosomal decoding (near-cognate tRNA-leu complex).; TRNA-FMET 4v8b AD 77 3.0 RF00005 URS000057545F_1110693 22437501 0030533 0006412 1110693 cgcgggguggagcagcccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<.<<..<<<<.........>>>>.<<<<<.......>>>>>......<<<<.......>>>>..>>>>>..... .((..(...(.(............)).((((.........))).)....(((((.......))))).)..))..... Crystal structure analysis of ribosomal decoding (near-cognate tRNA-leu complex).; TRNA-FMET 4v8b A1 10 3.0 22437501 uuuauguuuu .......... .......... Crystal structure analysis of ribosomal decoding (near-cognate tRNA-leu complex).; MRNA 4v8b BA 2912 3.0 RF02540,RF02541,RF00002 URS000080E23D_300852 22437501 0003735 0005840 300852 ggucaagaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaacggcccgcacgcgggccgaaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggauguuggcuuagaagcagccaucauuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucuugacc <<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.....>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....<<<<<<......>>>>>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<<..<<.......>>>..>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>>> ((((((((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((((((((..).))))))))....(.(((((((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....(((((........)))))....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((...((((((......)))).))...))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......(((((.(((..(((.........)))..))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........(((((..(((......(((((.((....)).)))))...)))............)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.((((.....))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...))))))))) Crystal structure analysis of ribosomal decoding (near-cognate tRNA-leu complex).; RNA (2912-MER) 4v8b BB 122 3.0 RF00001 URS00005AB4A7_300852 22437501 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga ..<<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> ..(((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).))))))))))) Crystal structure analysis of ribosomal decoding (near-cognate tRNA-leu complex).; 5S RIBOSOMAL RNA 4v8b CA 1506 3.0 RF00177,RF01959,RF01960 URS000080DEDF_300852 22437501 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggauc ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<.......>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<<....>>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((((((((((...))))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((((..(((((((....))))))).(.((((....)))).)))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((.(....(..(((.....)))).....).)))))...(.(((((....))))).)......)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((..........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure analysis of ribosomal decoding (near-cognate tRNA-leu complex).; 16S ribosomal RNA 4v8b CB 87 3.0 RF00005 URS00004630EA_1110693 22437501 0030533 0006412 1110693 gccgaggugguggaauugguagacacgcuaccuugaggugguagugcccaauagggcuuacggguucaagucccguccucgguacca <<<<<<<..<<<...........>>><<<<<<.......>>>>>><<<......>>>..<<<<<.......>>>>>>>>>>>>.... .(.((((..(((...........))).(((((.......))))).((.(....).))..(((((.......))))))))).)..... Crystal structure analysis of ribosomal decoding (near-cognate tRNA-leu complex).; TRNA-LEU 4v8b CC 77 3.0 RF00005 URS000057545F_1110693 22437501 0030533 0006412 1110693 cgcgggguggagcagcccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(.(((..]....))).)))))))..... Crystal structure analysis of ribosomal decoding (near-cognate tRNA-leu complex).; TRNA-FMET 4v8b CD 77 3.0 RF00005 URS000057545F_1110693 22437501 0030533 0006412 1110693 cgcgggguggagcagcccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<.<<<..<<<<.........>>>>.<<<<<.......>>>>>......<<<<.......>>>>..>>>>>..... .((......(.((.........)).).((((.........))))......((((.......)))).....))..... Crystal structure analysis of ribosomal decoding (near-cognate tRNA-leu complex).; TRNA-FMET 4v8b C1 10 3.0 22437501 uuuauguuuu .......... .......... Crystal structure analysis of ribosomal decoding (near-cognate tRNA-leu complex).; MRNA 4v8b DA 2907 3.0 RF02540,RF02541,RF00002 URS000080E23D_300852 22437501 0003735 0005840 300852 ggucaagaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaacggcccgcacgcgggccgaaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggauguuggcuuagaagcagccaucauuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucuugacc <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<[[<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>....<<<<<.....<......>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...(((....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>.]]...............<<....>>....]].........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....<<<<<<......>>>>>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<........>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<....<<<.......>>>....>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..((((...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.........<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<<..>>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<.(((..>>>>..)))>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))))>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>>> ((((((((......((((((((((.....(((..((((((((((((......((((((.[[..[[[)))...].((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((((((((..).))))))))....(.(((((((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....((((((......))))))....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((...((...(......)....))...))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......(((((.(((..(((.........)))..))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........(((((..(((......((((((((....))))))))...)))............)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.((((.....))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...))))))))) Crystal structure analysis of ribosomal decoding (near-cognate tRNA-leu complex).; RNA (2912-MER) 4v8b DB 122 3.0 RF00001 URS00005AB4A7_300852 22437501 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga ..<<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>>> ..(((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).))))))))))) Crystal structure analysis of ribosomal decoding (near-cognate tRNA-leu complex).; 5S RIBOSOMAL RNA 4v8c AA 2912 3.3 RF02540,RF02541,RF00002 URS000080E23D_300852 22437501 0003735 0005840 300852 ggucaagaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaacggcccgcacgcgggccgaaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggauguuggcuuagaagcagccaucauuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucuugacc <<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.....>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....<<<<<<......>>>>>>....>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<..<<<<<<<<..<<.......>>>..>>>>>>>...>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>>> ((((((((......((((((((((.....(((..((((((((((((......((((((.[[..[[[)))...].((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((((((((..).))))))))....(.(((((((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....(((((........)))))....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((...((((((......)))).))...))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......(((((.(((..(((.........)))..))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((.(((((((.((.....)))))))))......))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........(((((..(((......((((((((....))))))))...)))............)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.((((.....))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...))))))))) Crystal structure analysis of ribosomal decoding (near-cognate tRNA-leu complex with paromomycin).; RNA (2912-MER) 4v8c AB 122 3.3 RF00001 URS00005AB4A7_300852 22437501 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga ..<<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> ..(((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).))))))))))) Crystal structure analysis of ribosomal decoding (near-cognate tRNA-leu complex with paromomycin).; 5S RIBOSOMAL RNA 4v8c BA 2909 3.3 RF02540,RF02541,RF00002 URS000080E23D_300852 22437501 0003735 0005840 300852 ggucaagaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaacggcccgcacgcgggccgaaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggauguuggcuuagaagcagccaucauuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucuugacc 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((((((((......((((((((((.....(((..((((((((((((......((((((.[[..[[[)))...].((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((..)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...(((((((((..).))))))))....{.(((((((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).))))....(((((((((.[.....)))))))))....}.(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....((((((......))))))....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((...((...(......)....))...))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((..(((.........)))..))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........(((((..(((......((((((((....))))))))...)))............)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((.....))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...))))))))) Crystal structure analysis of ribosomal decoding (near-cognate tRNA-leu complex with paromomycin).; RNA (2912-MER) 4v8c BB 122 3.3 RF00001 URS00005AB4A7_300852 22437501 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga ..<<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>>> ..(((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).))))))))))) Crystal structure analysis of ribosomal decoding (near-cognate tRNA-leu complex with paromomycin).; 5S RIBOSOMAL RNA 4v8c CA 1506 3.3 RF00177,RF01959,RF01960 URS000080DEDF_300852 22437501 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggauc ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<<<...>>>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<<....>>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<..<.<<<<<<<........>>>>>>>>...>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(.((((((.((...)).)))))).).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(.(((....))).).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((((..(((.(((....))).)))...((((....))))..))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure analysis of ribosomal decoding (near-cognate tRNA-leu complex with paromomycin).; 16S ribosomal RNA 4v8c CB 87 3.3 RF00005 URS00004630EA_1110693 22437501 0030533 0006412 1110693 gccgaggugguggaauugguagacacgcuaccuugaggugguagugcccaauagggcuuacggguucaagucccguccucgguacca <<<<<<<..<<<...........>>><<<<<<.......>>>>>><<<<....>>>>..<<<<<.......>>>>>>>>>>>>.... (((((((..(((...........))).(((((.......))))).((((....))))..(((((.......)))))))))))).... Crystal structure analysis of ribosomal decoding (near-cognate tRNA-leu complex with paromomycin).; TRNA-LEU 4v8c CC 77 3.3 RF00005 URS000057545F_1110693 22437501 0030533 0006412 1110693 cgcgggguggagcagcccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure analysis of ribosomal decoding (near-cognate tRNA-leu complex with paromomycin).; TRNA-FMET 4v8c CD 77 3.3 RF00005 URS000057545F_1110693 22437501 0030533 0006412 1110693 cgcgggguggagcagcccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<.<<..<<<<.........>>>>.<<<<<.......>>>>>......<<<<.......>>>>.>.>>>>..... .((..(...((((.........))))..(((.........)))......(((((.......))))).)..))..... Crystal structure analysis of ribosomal decoding (near-cognate tRNA-leu complex with paromomycin).; TRNA-FMET 4v8c C1 10 3.3 22437501 uuuauguuuu .......... .......... Crystal structure analysis of ribosomal decoding (near-cognate tRNA-leu complex with paromomycin).; MRNA 4v8c DA 1506 3.3 RF00177,RF01959,RF01960 URS000080DEDF_300852 22437501 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggauc ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<.......>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<<....>>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((((((((((...))))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((((..(((((((....))))))).(.((((....)))).)))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((....(..(((.....)))).....)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((..........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure analysis of ribosomal decoding (near-cognate tRNA-leu complex with paromomycin).; 16S ribosomal RNA 4v8c DB 87 3.3 RF00005 URS00004630EA_1110693 22437501 0030533 0006412 1110693 gccgaggugguggaauugguagacacgcuaccuugaggugguagugcccaauagggcuuacggguucaagucccguccucgguacca <<<<<<<..<<<...........>>><<<<<<.......>>>>>><<<<....>>>>..<<<<<.......>>>>>>>>>>>>.... (((((((..(((...........))).(((((.......))))).((((....))))..(((((.......)))))))))))).... Crystal structure analysis of ribosomal decoding (near-cognate tRNA-leu complex with paromomycin).; TRNA-LEU 4v8c DC 77 3.3 RF00005 URS000057545F_1110693 22437501 0030533 0006412 1110693 cgcgggguggagcagcccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure analysis of ribosomal decoding (near-cognate tRNA-leu complex with paromomycin).; TRNA-FMET 4v8c DD 77 3.3 RF00005 URS000057545F_1110693 22437501 0030533 0006412 1110693 cgcgggguggagcagcccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<.<<..<<<<.........>>>>.<<<<<.......>>>>>......<<<.........>>>.>.>>>>..... .((.((...(((...........))).(((((.......))))).....(((((.......))))).).)))..... Crystal structure analysis of ribosomal decoding (near-cognate tRNA-leu complex with paromomycin).; TRNA-FMET 4v8c D1 10 3.3 22437501 uuuauguuuu .......... .......... Crystal structure analysis of ribosomal decoding (near-cognate tRNA-leu complex with paromomycin).; MRNA 4v8d AA 1502 3.0 RF00177,RF01959,RF01960 URS000080DEDF_300852 22437501 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcug ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<.<.....>>>.>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>....<<......>>...>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>. ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(.(((((...........))))).).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(.(((....))).).))))...(.((...)).).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((((..(((((((....))))))).(..(((....)))..)))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((.(....(..(((.....)))).....).)))))..((.(((((....))))).)...)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))} Structure analysis of ribosomal decoding (cognate tRNA-tyr complex).; 16S ribosomal RNA 4v8d AB 85 3.0 RF00005 URS00002D9DE2_1110693 22437501 0030533 0006412 1110693 ggugggguucccgagcggccaaagggagcagacuguanaucugccgucaucgacuucgaagguucgaauccuucccccaccacca <<<<<<<..<<<...........>>>.<<<<<.......>>>>>.<<<...>>>...<<<<<.......>>>>>>>>>>>>.... ((.((((..(((.....[.....))).(((((.......)))))..((...))....(((((..]....))))))))).)).... Structure analysis of ribosomal decoding (cognate tRNA-tyr complex).; TRNA-TYR 4v8d AC 77 3.0 RF00005 URS000057545F_1110693 22437501 0030533 0006412 1110693 cgcgggguggagcagcccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Structure analysis of ribosomal decoding (cognate tRNA-tyr complex).; TRNA-FMET 4v8d AD 85 3.0 RF00005 URS00002D9DE2_1110693 22437501 0030533 0006412 1110693 ggugggguucccgagcggccaaagggagcagacuguanaucugccgucaucgacuucgaagguucgaauccuucccccaccacca <<<<<<<..<<<...........>>>.<<<<<.......>>>>>.<<<...>>>...<<<<<.......>>>>>>>>>>>>.... (((((((..(((.....[.....))).(((((.......))))).(((...)))...(((((..]....)))))))))))).... Structure analysis of ribosomal decoding (cognate tRNA-tyr complex).; TRNA-TYR 4v8d A1 16 3.0 22437501 guaaaaauguacaaaa ................ ................ Structure analysis of ribosomal decoding (cognate tRNA-tyr complex).; MRNA 4v8d BA 2912 3.0 RF02540,RF02541,RF00002 URS000080E23D_300852 22437501 0003735 0005840 300852 ggucaagaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaacggcccgcacgcgggccgaaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggauguuggcuuagaagcagccaucauuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucuugacc <<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.....>>>>>>.>>....<<<<<.....<<....>>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....<<<<<<......>>>>>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<.<......>.>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<..<...<<<.........>>>...>..........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<.<<....>>.>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<<..<<.......>>>..>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>>> ((((((((......((((((((((.....(((..((((((((((((......((((((.[[..[[[)))...].((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....((((((......))))))....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((...((..((......))...))...))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......(((((..((..(((.........)))..))......(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........(((((..(((......((((..((....))..))))...)))............)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.((((.....))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...))))))))) Structure analysis of ribosomal decoding (cognate tRNA-tyr complex).; RNA (2912-MER) 4v8d BB 122 3.0 RF00001 URS00005AB4A7_300852 22437501 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga ..<<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> ..(((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).))))))))))) Structure analysis of ribosomal decoding (cognate tRNA-tyr complex).; 5S RIBOSOMAL RNA 4v8d CA 1502 3.0 RF00177,RF01959,RF01960 URS000080DEDF_300852 22437501 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcug ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<.......>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<.......<<<<<<<..<<<<<<<....>>>>>>>...<<<......>>>..>>>>>>>..<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>. ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((.(((((.....))))).)))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((((..(((((((....))))))).(.((........)).)))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...(...(((.....)))).....)))))))...(.(((((....))))).)......)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))} Structure analysis of ribosomal decoding (cognate tRNA-tyr complex).; 16S ribosomal RNA 4v8d CB 85 3.0 RF00005 URS00002D9DE2_1110693 22437501 0030533 0006412 1110693 ggugggguucccgagcggccaaagggagcagacuguanaucugccgucaucgacuucgaagguucgaauccuucccccaccacca <<<<<<<..<<<...........>>>..<<<<.......>>>>..<<<...>>>...<<<<<.......>>>>>>>>>>>>.... ((.((.(..(((...........))).(((((.......))))).(.(...).)...(((((.......)))))).)).)).... Structure analysis of ribosomal decoding (cognate tRNA-tyr complex).; TRNA-TYR 4v8d CC 77 3.0 RF00005 URS000057545F_1110693 22437501 0030533 0006412 1110693 cgcgggguggagcagcccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Structure analysis of ribosomal decoding (cognate tRNA-tyr complex).; TRNA-FMET 4v8d CD 85 3.0 RF00005 URS00002D9DE2_1110693 22437501 0030533 0006412 1110693 ggugggguucccgagcggccaaagggagcagacuguanaucugccgucaucgacuucgaagguucgaauccuucccccaccacca <<<<<<<..<<<...........>>>.<<<<<.......>>>>>.<<<...>>>...<<<<<.......>>>>>>>>>>>>.... (((((((..(((.....[.....))).(((((.......))))).(((...)))...(((((..]....)))))))))))).... Structure analysis of ribosomal decoding (cognate tRNA-tyr complex).; TRNA-TYR 4v8d C1 16 3.0 22437501 guaaaaauguacaaaa ................ ................ Structure analysis of ribosomal decoding (cognate tRNA-tyr complex).; MRNA 4v8d DA 2907 3.0 RF02540,RF02541,RF00002 URS000080E23D_300852 22437501 0003735 0005840 300852 ggucaagaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaacggcccgcacgcgggccgaaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggauguuggcuuagaagcagccaucauuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucuugacc <<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>....<<<<<.....<<....>>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....<<<<<<......>>>>>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<....<<<<<......>>>>.>....>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<.........>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<<..>>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>......>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>>> ((((((((......((((((((((.....(((..((((((((((((......((((((.[[..[[[)))...].((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((((((((..).))))))))....(.(((((((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....((((((......))))))....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((...((.(((......)))..))...))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((..(((.........)))..))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((.(((((((.((.....)))))))))......))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........(((((..(((.......((((.((....)).))))....)))............)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((.....))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...))))))))) Structure analysis of ribosomal decoding (cognate tRNA-tyr complex).; RNA (2912-MER) 4v8d DB 122 3.0 RF00001 URS00005AB4A7_300852 22437501 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga ..<<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> ..(((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).))))))))))) Structure analysis of ribosomal decoding (cognate tRNA-tyr complex).; 5S RIBOSOMAL RNA 4v8e AA 2912 3.3 RF02540,RF02541,RF00002 URS000080E23D_300852 22437501 0003735 0005840 300852 ggucaagaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaacggcccgcacgcgggccgaaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggauguuggcuuagaagcagccaucauuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucuugacc <<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.....>>>>>>.>>....<<<<<.....<<....>>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....<<<<<<......>>>>>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<.<......>.>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<.........>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<<..<<.......>>>..>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>>> ((((((((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....(((((........)))))....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((...((..((......))...))...))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......(((((..((..(((.........)))..))......(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((.(((((((((.(.........(((((..(((......(((((.((....)).)))))...)))............)))))).))))))))).))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.((((.....))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...))))))))) Crystal structure analysis of ribosomal decoding (near-cognate tRNA-tyr complex).; RNA (2912-MER) 4v8e AB 122 3.3 RF00001 URS00005AB4A7_300852 22437501 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga ..<<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>>> ..(((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).))))))))))) Crystal structure analysis of ribosomal decoding (near-cognate tRNA-tyr complex).; 5S RIBOSOMAL RNA 4v8e BA 1502 3.3 RF00177,RF01959,RF01960 URS000080DEDF_300852 22437501 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcug ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<.<.....>>>.>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>....<<......>>...>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<..<.<<<<<<<........>>>>>>>>...>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>. ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(.((((((.........)))))).).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...(.((...)).).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((((..(((((((....))))))).(.(((......))).)))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((....(..(((.....)))).....)))))))..((.(((((....))))).)...)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))} Crystal structure analysis of ribosomal decoding (near-cognate tRNA-tyr complex).; 16S ribosomal RNA 4v8e BB 85 3.3 RF00005 URS00002D9DE2_1110693 22437501 0030533 0006412 1110693 ggugggguucccgagcggccaaagggagcagacuguanaucugccgucaucgacuucgaagguucgaauccuucccccaccacca <<<<<<<..<<<...........>>>.<<<<<.......>>>>>.<<<...>>>...<<<<<.......>>>>>>>>>>>>.... (((((((..(((.....[.....))).(((((.......))))).(((...)))...(((((..]....)))))))))))).... Crystal structure analysis of ribosomal decoding (near-cognate tRNA-tyr complex).; TRNA-TYR 4v8e BC 77 3.3 RF00005 URS000057545F_1110693 22437501 0030533 0006412 1110693 cgcgggguggagcagcccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure analysis of ribosomal decoding (near-cognate tRNA-tyr complex).; TRNA-FMET 4v8e BD 85 3.3 RF00005 URS00002D9DE2_1110693 22437501 0030533 0006412 1110693 ggugggguucccgagcggccaaagggagcagacuguanaucugccgucaucgacuucgaagguucgaauccuucccccaccacca <<<<<<<..<<<...........>>>.<<<<<.......>>>>>.<<<...>>>...<<<<<.......>>>>>>>>>>>>.... (((((((..(((.....[.....))).(((((.......))))).(((...)))...(((((..]....)))))))))))).... Crystal structure analysis of ribosomal decoding (near-cognate tRNA-tyr complex).; TRNA-TYR 4v8e B1 16 3.3 22437501 guaaaaaugugcaaaa ................ ................ Crystal structure analysis of ribosomal decoding (near-cognate tRNA-tyr complex).; MRNA 4v8e CA 2907 3.3 RF02540,RF02541,RF00002 URS000080E23D_300852 22437501 0003735 0005840 300852 ggucaagaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaacggcccgcacgcgggccgaaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggauguuggcuuagaagcagccaucauuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucuugacc <<<<<<<<......<<<<<<<<<<<.....<<.<<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>....<<<<<.....<<....>>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>>..............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....<<<<<<......>>>>>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<....<<<<<......>>>>.>....>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<.........>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<<..>>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<<..>>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>>> ((((((((......((((((((((.....(((..((((((((((((......((((((.[[..[[[)))...].((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((((((((..).))))))))....(.(((((((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....((((.((((.[.....)))).))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....((((((......))))))....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((...((.(((......)))..))...))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((.......{.(((((.(((..(((.........)))..))).....(...((......)).).))))).....)))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.(((((.....))))).))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........(((((..(((.......((((.((....)).))))....)))............)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((.....))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...))))))))) Crystal structure analysis of ribosomal decoding (near-cognate tRNA-tyr complex).; RNA (2912-MER) 4v8e CB 122 3.3 RF00001 URS00005AB4A7_300852 22437501 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga ..<<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>>> ..(((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).))))))))))) Crystal structure analysis of ribosomal decoding (near-cognate tRNA-tyr complex).; 5S RIBOSOMAL RNA 4v8e DA 1502 3.3 RF00177,RF01959,RF01960 URS000080DEDF_300852 22437501 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcug ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<.......>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<......>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>.........<.<<<<<<<........>>>>>>>>.........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>. ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((.((...)).)))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((......((((((((..(((((((....))))))).(.((((....)))).)))))))))..((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((.(.......(((.....)))......).)))))...(.(((((....))))).)......)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((..........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))} Crystal structure analysis of ribosomal decoding (near-cognate tRNA-tyr complex).; 16S ribosomal RNA 4v8e DB 85 3.3 RF00005 URS00002D9DE2_1110693 22437501 0030533 0006412 1110693 ggugggguucccgagcggccaaagggagcagacuguanaucugccgucaucgacuucgaagguucgaauccuucccccaccacca <<<<<<<..<<<...........>>>.<<<<<.......>>>>>.<<<...>>>...<<<<<.......>>>>>>>>>>>>.... (((((((..(((.....[.....))).(((((.......))))).(((...)))...(((((..]....)))))))))))).... Crystal structure analysis of ribosomal decoding (near-cognate tRNA-tyr complex).; TRNA-TYR 4v8e DC 77 3.3 RF00005 URS000057545F_1110693 22437501 0030533 0006412 1110693 cgcgggguggagcagcccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure analysis of ribosomal decoding (near-cognate tRNA-tyr complex).; TRNA-FMET 4v8e DD 85 3.3 RF00005 URS00002D9DE2_1110693 22437501 0030533 0006412 1110693 ggugggguucccgagcggccaaagggagcagacuguanaucugccgucaucgacuucgaagguucgaauccuucccccaccacca <<<<<<<..<<<...........>>>.<<<<<.......>>>>>.<<<...>>>...<<<<<.......>>>>>>>>>>>>.... (((((((..(((.....[.....))).(((((.......))))).(((...)))...(((((..]....)))))))))))).... Crystal structure analysis of ribosomal decoding (near-cognate tRNA-tyr complex).; TRNA-TYR 4v8e D1 16 3.3 22437501 guaaaaaugugcaaaa ................ ................ Crystal structure analysis of ribosomal decoding (near-cognate tRNA-tyr complex).; MRNA 4v8f AA 2912 3.3 RF02540,RF02541,RF00002 URS000080E23D_300852 22437501 0003735 0005840 300852 ggucaagaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaacggcccgcacgcgggccgaaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggauguuggcuuagaagcagccaucauuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucuugacc <<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.....>>>>>>.>>....<<<<<.....<......>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....<<<<<<......>>>>>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<.<......>.>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<.........>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<<<<<<<<<..<<.......>>>..>>>>>>>..>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>>> ((((((((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....((((((......))))))....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((...((.(((......)))..))...))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......(((((..((..(((.........)))..))......(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((.(((((((.((.....)))))))))......))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........(((((..(((......(((((.((....)).)))))...)))............)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.((((.....))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...))))))))) Crystal structure analysis of ribosomal decoding (near-cognate tRNA-ttyr complex with paromomycin).; RNA (2912-MER) 4v8f AB 122 3.3 RF00001 URS00005AB4A7_300852 22437501 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga ..<<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>>> ..(((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).))))))))))) Crystal structure analysis of ribosomal decoding (near-cognate tRNA-ttyr complex with paromomycin).; 5S RIBOSOMAL RNA 4v8f BA 1502 3.3 RF00177,RF01959,RF01960 URS000080DEDF_300852 22437501 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcug ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<.<.....>>>.>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>....<<......>>...>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>.........<.<<<<<<<........>>>>>>>>.........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>. ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(.((((((.........)))))).).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...(.((...)).).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((.(..((((((((((......((........))........(.(((((((..(...((((((((..(((((((....))))))).(.(((......))).)))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((.(....(..(((.....)))).....).)))))...(.(((((....))))).)......)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..).))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))} Crystal structure analysis of ribosomal decoding (near-cognate tRNA-ttyr complex with paromomycin).; 16S ribosomal RNA 4v8f BB 85 3.3 RF00005 URS00002D9DE2_1110693 22437501 0030533 0006412 1110693 ggugggguucccgagcggccaaagggagcagacuguanaucugccgucaucgacuucgaagguucgaauccuucccccaccacca <<<<<<<..<<<...........>>>.<<<<<.......>>>>>.<<<...>>>...<<<<<.......>>>>>>>>>>>>.... (((((.(..(((...........))).(((((.......))))).(((...)))...(((((.......)))))).))))).... Crystal structure analysis of ribosomal decoding (near-cognate tRNA-ttyr complex with paromomycin).; TRNA-TYR 4v8f BC 77 3.3 RF00005 URS000057545F_1110693 22437501 0030533 0006412 1110693 cgcgggguggagcagcccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure analysis of ribosomal decoding (near-cognate tRNA-ttyr complex with paromomycin).; TRNA-FMET 4v8f BD 85 3.3 RF00005 URS00002D9DE2_1110693 22437501 0030533 0006412 1110693 ggugggguucccgagcggccaaagggagcagacuguanaucugccgucaucgacuucgaagguucgaauccuucccccaccacca <<<<<<<..<<<...........>>>.<<<<<.......>>>>>.<<<...>>>...<<<<<.......>>>>>>>>>>>>.... (((((((..(((.....[.....))).(((((.......))))).(((...)))...(((((..]....)))))))))))).... Crystal structure analysis of ribosomal decoding (near-cognate tRNA-ttyr complex with paromomycin).; TRNA-TYR 4v8f B1 16 3.3 22437501 guaaaaaugugcaaaa ................ ................ Crystal structure analysis of ribosomal decoding (near-cognate tRNA-ttyr complex with paromomycin).; MRNA 4v8f CA 1502 3.3 RF00177,RF01959,RF01960 URS000080DEDF_300852 22437501 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcug ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<.......>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<......>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>. ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((((((((((...))))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((......((((((((..(((((((....)))))))...((((....))))..))))))))..((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((.(.......(((.....)))......).))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))} Crystal structure analysis of ribosomal decoding (near-cognate tRNA-ttyr complex with paromomycin).; 16S ribosomal RNA 4v8f CB 85 3.3 RF00005 URS00002D9DE2_1110693 22437501 0030533 0006412 1110693 ggugggguucccgagcggccaaagggagcagacuguanaucugccgucaucgacuucgaagguucgaauccuucccccaccacca <<<<<<<..<<<...........>>>.<<<<<.......>>>>>.<<<...>>>...<<<<<.......>>>>>>>>>>>>.... ((.((((..((.............)).(((((.......))))).(((...)))...(((((.......))))))))).)).... Crystal structure analysis of ribosomal decoding (near-cognate tRNA-ttyr complex with paromomycin).; TRNA-TYR 4v8f CC 77 3.3 RF00005 URS000057545F_1110693 22437501 0030533 0006412 1110693 cgcgggguggagcagcccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure analysis of ribosomal decoding (near-cognate tRNA-ttyr complex with paromomycin).; TRNA-FMET 4v8f CD 85 3.3 RF00005 URS00002D9DE2_1110693 22437501 0030533 0006412 1110693 ggugggguucccgagcggccaaagggagcagacuguanaucugccgucaucgacuucgaagguucgaauccuucccccaccacca <<<<<<<..<<<...........>>>.<<<<<.......>>>>>.<<<...>>>...<<<<<.......>>>>>>>>>>>>.... (((((((..(((.....[..[..))).(((((.......))))).(((...)))]..(((((..]....)))))))))))).... Crystal structure analysis of ribosomal decoding (near-cognate tRNA-ttyr complex with paromomycin).; TRNA-TYR 4v8f C1 16 3.3 22437501 guaaaaaugugcaaaa ................ ................ Crystal structure analysis of ribosomal decoding (near-cognate tRNA-ttyr complex with paromomycin).; MRNA 4v8f DA 2907 3.3 RF02540,RF02541,RF00002 URS000080E23D_300852 22437501 0003735 0005840 300852 ggucaagaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaacggcccgcacgcgggccgaaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggauguuggcuuagaagcagccaucauuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucuugacc <<<<<<<<......<<<<<<<<<<<.....<<.<<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>....<<<<<.....<<....>>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>>..............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....<<<<<<......>>>>>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<....<<<<<......>>>>.>....>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<.........>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<<..>>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<<..>>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>>> ((((((((......((((((((((.....(((..((((((((((((......((((((.[[..[[[)))...].((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...(((((((((..).))))))))....{.(((((((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).))))....(((((((((.[.....)))))))))....}.(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....((((((......))))))....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((...((.(((......)))..))...))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((..(((.........)))..))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((.(((((((.((.....)))))))))......))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........(((((..(((.......((((.((....)).))))....)))............)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(.(((((.....(....)....))))).).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((.....))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...))))))))) Crystal structure analysis of ribosomal decoding (near-cognate tRNA-ttyr complex with paromomycin).; RNA (2912-MER) 4v8f DB 122 3.3 RF00001 URS00005AB4A7_300852 22437501 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga ..<<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>>> ..((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......)))..)))))))))) Crystal structure analysis of ribosomal decoding (near-cognate tRNA-ttyr complex with paromomycin).; 5S RIBOSOMAL RNA 4v8g AA 1505 3.0 RF00177,RF01959,RF01960 URS000080E226_300852 22605777 0003735 0005840 300852 uguuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggggucuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggauc .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<...>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<...<<<<<<......>>>>>.>...>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<..<<<<<..<<<<<<<<<<.......<........>...........<<<<<<<......<<<<<<<<..<..<<<<....>>>>.>..<...<......>...>>>>>>>>>..<..<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>.>....>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>.....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<.....<<....>>..>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((.....)))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((..((((....))))..))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((......(.]]])........))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((.((((((..((((((((((......((........))........(.(((((((..(...((((((((....(.(((....))).).......((....))....))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..((...(((.....)))).)...))))))).....(.(((....))).)........)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))...........(((((((........))))))).......)..))))))....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((..(..((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of RMF bound to the 70S ribosome.; 16S Ribosomal RNA 4v8g BA 2809 3.0 RF02540,RF02541,RF00002 URS00001698E8_300852 22605777 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuaggggccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagcggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>....<<<<<.....<<....>>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<...>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<...>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>.............>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((...))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((((((((..).))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((()))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((.(.((((.)).)))..)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((...............)))))))))).))..........]]].)....))))))))))...)))))))(((((((())))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((.((((((.(......[..(((((...((......((((((((....))))))))...))...........].)))))).)))))).)))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((((.(((((.........)))))...))((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))...(((.))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of RMF bound to the 70S ribosome.; 23S Ribosomal RNA 4v8g BB 120 3.0 RF00001 URS00005F2F4B_300852 22605777 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> (((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).))))))))))) Crystal structure of RMF bound to the 70S ribosome.; 5S Ribosomal RNA 4v8g CA 1501 3.0 RF00177,RF01959,RF01960 URS000080E226_300852 22605777 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<.>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<...<<<<<<......>>>>>.>...>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<.<<<....>>>.>>>....<.......>....>>>>>>>>..<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>....>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<.....<<....>>..>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((((((((.))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((..((((....))))..))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((......(.]]])........))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((((...((.(((....))).).)......(....).....))))))))).((.((....((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..((...(((.....)))).)...))))))).....(((((....)))))........)))).....).).)))...))..))))....)))))))..[)).)))))))).....(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....).....))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((..(..((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of RMF bound to the 70S ribosome.; 16S Ribosomal RNA 4v8g DA 2814 3.0 RF02540,RF02541,RF00002 URS00001698E8_300852 22605777 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagcggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>....<<<<<.....<<....>>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<..>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<...>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>.............>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((...))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((((((((..).))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((()))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((.(.((((())).)))..)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((...............)))))))))).))..........]]].)....))))))))))...)))))))(((((((())))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((.((((((.(......[..(((((..(((......((((((((....))))))))...)))..........].)))))).)))))).)))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((((.(((((.........)))))...))((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))...(((.))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of RMF bound to the 70S ribosome.; 23S Ribosomal RNA 4v8g DB 120 3.0 RF00001 URS00005F2F4B_300852 22605777 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> (((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).))))))))))) Crystal structure of RMF bound to the 70S ribosome.; 5S Ribosomal RNA 4v8h AA 1501 3.1 RF00177,RF01959,RF01960 URS000080E226_300852 22605777 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugg .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<<..>>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<..<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<......>>>>>>.....<......>.....>>>>>>>..<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>....>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>.....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<.....<<....>>..>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.. .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((.(....).)))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((.(......((((((.....))))))....).))))))..)))))))))..(((.(((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..)))))..))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((......((((((((..(((.(((....))).)))....((......))...))))))))..((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..((...(((.....)))).)...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((..........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((.....((....))..)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}. Crystal structure of HPF bound to the 70S ribosome.; 16S Ribosomal RNA 4v8h BA 2837 3.1 RF02540,RF02541,RF00002 URS000080E314_300852 22605777 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgggccgcggcccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagcggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<<<<<<..>>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<...>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<<..>>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((...))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((((((((..).))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....(((((((..)))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((.(.((((((......)))).)))..)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((...............)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...(((((((((((((((..((.....)).)))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((.((((((((((.(......[..(((((..(((......((((((((....))))))))...)))..........].)))))).)))))))))).)))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((((.(((((.........)))))...))((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))..((((.))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of HPF bound to the 70S ribosome.; 23S Ribosomal RNA 4v8h BB 120 3.1 RF00001 URS00005F2F4B_300852 22605777 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> (((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).))))))))))) Crystal structure of HPF bound to the 70S ribosome.; 5S Ribosomal RNA 4v8h CA 1497 3.1 RF00177,RF01959,RF01960 URS000080E226_300852 22605777 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugg .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<........<<........>>..........<<<<<<<......<<<<<<<....<<<<<<....>>>>>>.....<<.....>>.....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>......>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<.....<<....>>..>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.. .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((())))))))).)))))......(((......((((((((..((...(((((((.(((((....((((.(....).)))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((.(......((((((.....))))))....).))))))..)))))))))..(((.(((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..)))))..))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((.(.((..(((((..((((.(((((......((........))..........(((((((......((((((((...((.(((....))).).).....(......)....))))))))..((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(....(((.....)))..)...))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).))).)))).(....((((((.....(((..(((.((((....))))).))....))).....)))))).......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...).)))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((.....((....))..)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}. Crystal structure of HPF bound to the 70S ribosome.; 16S Ribosomal RNA 4v8h DA 2814 3.1 RF02540,RF02541,RF00002 URS000080E314_300852 22605777 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgggccgcggcccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuaggggccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagcggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccga .........<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<<<<<<..>>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<...>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<...>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<..>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<<..>>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>.. .........((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((...))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((((((((..).))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....(((((((..)))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((.(.((((.)).)))..)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((...............)))))))))).))..........]]].)....))))))))))...)))))))(((((((())))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...(((((((((((((((..((.....)).)))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((.((((((((((.(......[..(((((..(((......((((((((....))))))))...)))..........].)))))).)))))))))).)))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((((.(((((.........)))))...))((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))..((((.))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...)))).. Crystal structure of HPF bound to the 70S ribosome.; 23S Ribosomal RNA 4v8h DB 120 3.1 RF00001 URS00005F2F4B_300852 22605777 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> (((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).))))))))))) Crystal structure of HPF bound to the 70S ribosome.; 5S Ribosomal RNA 4v8i AA 1493 2.7 RF00177,RF01959,RF01960 URS000080E226_274 22605777 0003735 0005840 274 guuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacucgaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<..>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>.....<......>....>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<.....<<....>>..>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((())))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((...(((((....)))))...))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((()))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...((((((((..(((.(((....))).))).....((....))....))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..((...(((.....)))).)...))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((..(..((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.. Crystal structure of YfiA bound to the 70S ribosome.; 16S Ribosomal RNA 4v8i BA 2827 2.7 RF02540,RF02541,RF00002 URS00001698E8_274 22605777 0003735 0005840 274 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgggccgcggcccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagcggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgagucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<...>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<<<<<<..>>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<...>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<......>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>...>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((((((((..).))))))))....(.(((((((((..(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((...))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....(((((((())))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((.(.((((((......)))).)))..)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((...............)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((.((((((((.(.........(((((..(((........(((.((....)).))).....)))............)))))).)))))))).)))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((((.(((((.........)))))...))((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....)))))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))...(((.))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...))) Crystal structure of YfiA bound to the 70S ribosome.; 23S Ribosomal RNA 4v8i BB 120 2.7 RF00001 URS00005F2F4B_274 22605777 0003735 0005840 274 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>. .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of YfiA bound to the 70S ribosome.; 5S Ribosomal RNA 4v8i CA 1491 2.7 RF00177,RF01959,RF01960 URS000080E226_274 22605777 0003735 0005840 274 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugg .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<..>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<......>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<.....<<....>>..>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.. .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((((()))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((.(.(((((....))))).).))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((((..(((((((....))))))).(.((((....)))).)))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..((...(((.....)))).)...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((..(..((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}. Crystal structure of YfiA bound to the 70S ribosome.; 16S Ribosomal RNA 4v8i DA 2798 2.7 RF02540,RF02541,RF00002 URS00001698E8_274 22605777 0003735 0005840 274 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucgcgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgagucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<.<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>..>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<...>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<..>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<......>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>...>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((((((((..).))))))))....(.(((((((((.(...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)..)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((...))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((()))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((.(.((((((......)))).)))..)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((((((()))))))))).))..........]]].)....))))))))))...)))))))(((((((())))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((.((((((((.(.........(((((..(((........(((.((....)).))).....)))............)))))).)))))))).)))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((((.(((((.........)))))...))((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))...(((.))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...))) Crystal structure of YfiA bound to the 70S ribosome.; 23S Ribosomal RNA 4v8i DB 120 2.7 RF00001 URS00005F2F4B_274 22605777 0003735 0005840 274 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>. .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of YfiA bound to the 70S ribosome.; 5S Ribosomal RNA 4v8j AA 1504 3.9 RF00177,RF01959,RF01960 URS000080E130_300852 23630274 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgugaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<...........>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>....<<<<.<<<<<....>>>>>.>>>>...<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<......>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<.<..<<<<<<<.<..<<<......>>>.....>.>>>>>>>...>.......<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<.<<..<<<<<<<....>>>>>>>....<<.....>>....>>.>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<....<<.....>>.>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<...<<<<....>>>>...>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<<..>>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((((((...........))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).(((......)))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((.((.(...(((((((....)))))))...................))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((........................))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((...(..((((....))))..).....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Crystal structure of the bacterial ribosome ram mutation G347U.; 16S rRNA 4v8j AW 76 3.9 RF00005 URS00005AA258_1110693 23630274 0030533 0006412 1110693 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... ((((((...((((.....[..)))).((((.........)))).....(((((..]....))))).)))))).... Crystal structure of the bacterial ribosome ram mutation G347U.; tRNA-Phe 4v8j AV 77 3.9 RF00005 URS000041AF00_1110693 23630274 0030533 0006412 1110693 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((.(..((.(......[..).)).(((((.......))))).....((((...].....))))).))))..... Crystal structure of the bacterial ribosome ram mutation G347U.; tRNA-fMet 4v8j AY 17 3.9 RF00005 URS00005AA258_1110693 23630274 0030533 0006412 1110693 ggggauugaaaaucccc <<<<<<.....>>>>>> .((((.......)))). Crystal structure of the bacterial ribosome ram mutation G347U.; tRNA-Phe 4v8j BA 2803 3.9 RF02540,RF02541,RF00002 URS000080DFFB_300852 23630274 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucgcgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggcccgggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>....<<<<<.....<<....>>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<......<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>..>>>>......>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<.>>>>>>>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<...<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>..>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<................>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<.......>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> .(.......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((..))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...((((((((.....))))))))....{.(((((((((.(...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)..)))))).))))....(((((((((.[.....)))))))))....}.(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((.((((.)))).))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((....((...(((.((((...((((((......)))).))...)))).)))..)).....)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((((....................))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.((...{{....))))))(((...((((((((((..((...((.....))..))..).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((((.......)))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((.(.(((.((((.(......[..(((((..(((.......(((((((....)))))))....)))..........].)))))).)))).))).).)))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.((((...........))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))...(.........).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...)))).....). Crystal structure of the bacterial ribosome ram mutation G347U.; 23S rRNA 4v8j BB 119 3.9 RF00001 URS00005F2F4B_300852 23630274 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>> .((((((((((....((((((((....(((.(((...(.....)...)))...)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))) Crystal structure of the bacterial ribosome ram mutation G347U.; 5S rRNA 4v8j CA 1503 3.9 RF00177,RF01959,RF01960 URS000080E130_300852 23630274 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgugaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugg ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<...........>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<......>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>....<<.....>>....>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<....<<.....>>.>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<<..>>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.. ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((.((...........)).)))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).(((......)))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((..(...(((((((....)))))))...................).))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((........................))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}. Crystal structure of the bacterial ribosome ram mutation G347U.; 16S rRNA 4v8j CW 76 3.9 RF00005 URS00005AA258_1110693 23630274 0030533 0006412 1110693 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<..........>>>.<<<<<.......>>>>>.....<<<.<........>>>>>>>>>>>.... .....((..(((..........))).(((...........)))......((...........)).))......... Crystal structure of the bacterial ribosome ram mutation G347U.; tRNA-Phe 4v8j CV 77 3.9 RF00005 URS000041AF00_1110693 23630274 0030533 0006412 1110693 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ..(((((..((((......[..)))).(((((.......))))).....(.(((..]....))).))))))...... Crystal structure of the bacterial ribosome ram mutation G347U.; tRNA-fMet 4v8j CY 17 3.9 RF00005 URS00005AA258_1110693 23630274 0030533 0006412 1110693 ggggauugaaaaucccc .<<<<<.....>>>>>. .((((.......)))). Crystal structure of the bacterial ribosome ram mutation G347U.; tRNA-Phe 4v8j CX 10 3.9 23630274 aaaauguuca .......... .......... Crystal structure of the bacterial ribosome ram mutation G347U.; messenger RNA 4v8j DA 2803 3.9 RF02540,RF02541,RF00002 URS000080DFFB_300852 23630274 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucgcgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggcccgggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu 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.(.......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((..))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...((((((((.....))))))))....{.(((((((((.(...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)..)))))).))))....(((((((((.[.....)))))))))....}.(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((.((((.)))).))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((...((((((......)))).))...)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((((....................))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.((...{{....))))))(((...((((((((((..((...((.....))..))..).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((((.......)))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((.(.(((.((((.(......[..(((((..(((.......(((((((....)))))))....)))..........].)))))).)))).))).).)))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.((((...........))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))...(.........).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...)))).....). Crystal structure of the bacterial ribosome ram mutation G347U.; 23S rRNA 4v8j DB 119 3.9 RF00001 URS00005F2F4B_300852 23630274 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>> .((((((((((....((((((((....(((.(((...(.....)...)))...)))...)))))).))(((.......(((((.((....)).))))).......))).)))))))))) Crystal structure of the bacterial ribosome ram mutation G347U.; 5S rRNA 4v8m BA 1847 5.57 RF02543,RF02540 URS000080DED1_5691 23395961 0003735 0005840 5691 cagaccugaguguggcaggaccacccgcuaaacuuaagcauauuacucagcggaggaaaagaaaacaaccgugauucucucagucagcggcgagcgaagagggauucaacucguugccgaaucgggucuuauaugaccucgaacuguggcaccauuuuuguggccguucuuauagggcuggugcaggcguggcggaauucaauugcaaagcaaacccguugcugaacacauuuacaacccuucaugugaguauugagccaaagaaggugucagcccauuacauuccuuagccacggagccuacgcgccuccucauguucgguccaagagaguagcacuguuugggaaugcagugucaagccggcagguauuugucugccaagguuaaauauagaguaggaagaccgauagcgaacaaguagcgugagcgaaaguuugaaaaguacuuuggaaagagagugacauagaaccugaaaucgugacaacgacaauggaaguaccuucauuucuuuuuuuuacggccagacccaaccucgccgcgcaauuucgguucaacauccuucacugugcggguuucucuuuugaggucauggggugcgugagugggcggaauaaagggucgguguguuguguguggguuuuuucucucacucucuuccuccuucccuguucgugcgucucgacgcuggcgauggaaauggggugcccccacccgucuugaaacacggaccaaggagucaaacagacgcgcaagggaggaguauguaugugagaacucuuuucucguacugaaagggagagugugauuuuacacccguggcgugcgcaauuucucuuuuuuguguuuuugcccaacgccggccggccccccgugggcugcgcgcgagugugccuguuuggacccgaaagguggugaacuaugccugaacaaggugaagcccggggaaaccccgguggaggccuguagcgaugcugacgugcaaaucgcucguacgauuuggguaucggagcgaaagacucaucgaaccaccuaguagcugguucacgucgaaguuucccucaggauagcuggugcuugucuuuaagaaguauugugcgguaaagcaaaugauuagaggcauugguguucuuguaauaucgaccuauucucaaacuuuaaaugugcaaacaacccagccuuaguuauuuuaacaaggcuuuuggguacauaagaauugaggcaccaagugggccuucuucgguaagcggagcaggcgaugcggaaugaaccgcuuagggauauguggcgucaaaacuugugggcucauucucgauacgugaaaaggguguugguggauagggacaguuggacgguggccauggaagucggcauccgcuaaggaguguguaacaacucaccaaccgaauccaccggccccgaaaauggaugacgcuuaagccccaugugcgugauugcccauuauuccuuuggugagggcggcuauauuucuuugugagaaaguguagcccucccgauguagacguggcgugggggugaggacgaagccgauggcgcgagccucggauggacccgccucuagugcagaucuugguuggcguagcaaagaucuaacggaauauuuuuucuuaaaugcaacguuggauacuggagcggggaaggauuucgugccaacggcacucguacacgaguuguucggucacugagcacaacguuacaccguuuuguuaggaaagugaagguggucggcgcacaucucccuuuuuugggguuuguguguuuuaccggcuuaucugaaaaggggcaacagagaaccugggaugauauuccaaaaagaaauugcauguggg ........................<<<<<.....<......>......>>>>>...........<......>...<<<<<......<<.....>>....>>>>>....<<<............<<<<<......>>>>>...........................<<..<..<<<<..<<<<<<<<.<<<<<........<.<<...<<<<<.....>>>>>....<<<<............>>>>...>>.>..(........<<......)>>.............>>>>>....>>>..>>>>>>>>>...>...>>............<<<<<<<........>>>>>>>......<<<<<........>>>>>..>>>....................................<<....>>................<<<......>>>...................................<<..<<<<...<<<<<....<..<<.....<<..<.<<.....<.<<<<<<.<..................>.>>>>>..>.>.......>>.>....>>................<<<.<....<<..<.........<<<.<<<......>>>.>>>..........>..>>..>>>>...............>>.>....>>>>>..>>>>..>>..<<<<........>>>><<<<<<.....<<.<<<.<<<<<..<<<...<<................>>...>>>...<<....>>....<<<<<....>>>>>...<<<...<<<<<<..........>>>>>>......>>>.<<<<<<<<...........>>>>>.>>>...>>>>>.>>>.>>...<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<.<<<....>>>.>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>...<<<<<......<<<....>>><.<.<<<<<<<.........<<....<<<<<<<...<<<....<<<..<.<<<....<<<<<<.....>>>>>>..>>>.>..>>>..>>.>...>>>>>>>...<<<<<<<<<<.<<.......>>>>>>>>...>>>>.........>>..>>>>>>>..>>.<<<<.<<<<<.....>>>>>.>>>>...<<<<......>>>>..<<<<<<<...<<<(((.........<<<<........<...........<<<.<<<<<<<<<........<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>....>>>>>>>>>>>>..........))).>....>>>>.............>>>...>>>>>>><<<<.<<<<<.....<<<<..............>>>>..>>>>>>>>>....>>>>>.....<<<<<<..<.......<<<..<<<....>>>.>>>......>.>>>>>>.........>>>>>>..............<<<<<<......<<........>>......>>>>>>....................<<<<<....<<.....>>..>>>>>....<<......<...<<..<<<<......>>>>..........<<..<<<.<<<<.<.<<<<<<..<<<<......>>>>..>>>>>>..>.>>>>.>>>..>>........>>....>.....<<<...........>....>>.>>........... .......................(((((..........[..........)))).).........((....))...((((.......((.]...)).....))))....((.(..........(.((((......))))..)..........................(..(..(((...((((((((.(((((......(.(.(....(((((.....))))).....(((..(......)..))).....).)).((.......[[.....))]].............)))))....)))..))))).)))...)...)........)....(((((((........)))))))......(((((........)))))...))....................................((....)).............(..((((....))))............)......................((..(((((.((.(((........((....((..(.(((......(((.((.(...(........).....).)).))..).......).)).)....))..............(.(.(...(.(.(..((.(.(....(((.(((......))).)))....).)..))..)).).).)......).......)).......))).)))))))..))..((((........))))((((((........(((.(((....(((...((................))...)))...((....))....((((......))))...((((..((.(((..........))).))....).))).(((((((.............)))).))).....))).)))......((.(...((((((.....(((((((((..(((....(((.(((....))).))).....)))...(((..((.((........)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((........((..(.((((((....(((....((...(.(((......(.((.....)).)....))).)...))..)).)....))))))...((((((((((.((.......))))))))...)))).......).)).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((.[[[...(.....((((........(...........(((.((((((((((.......(((((.(((...((.........))...))).....(...(........).).)))))...)))))))))))))..........]]].)....))))..)...........))...)))))))((((.(((((.....(.(.((..........)).).)..)))))))))....))))).)..((((((((.((.....((((..(((....))).))).)...))))))))))........))))))..............((.(((.....(((........))).....))).))....................(((((....((.....))..)))))....((......(...((...(((......)))...........((..(((..(((.....((((...(((......)))...))))......)))..)))..))........))....).....((((.........))....)).))........... High-resolution cryo-electron microscopy structure of the Trypanosoma brucei ribosome; ALPHA CHAIN OF THE LARGE RIBOSOMAL SUBUNIT 28S RRNA 4v8m BB 1465 5.57 RF02543,RF02540 URS000080DDF3_5691 23395961 0003735 0005840 5691 ucccaacugcagaccguacucaucaccgcaucagguccccaagcaucgaaugcucugguaacauagagaaagguacacucagggaagucggcaaaauagaugcguaaguucgcaagaagcauuggcucugagggcaaaguggggguccacaggagggccaguguccuuugaaggcuacccucccgagccguaucuacuaaccuccuucugguguguuguuuuuacgucucacucccgcgcagguguuuucgcuuccuuuuuuugguugcgcaccuacaaauugccaacucagaacugcuuacggcggggaauccaacuguauaauuaaaacauagguuugugaugcauccaagugguguaugucgcaaacugauuucugcccagugcucugaaugucaacgugagagauucaccgacgcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucuuccaauuagagacgcgcaugaauggauuaaugagauucccucugucccgaguuacuaucuagcgaaacgacagucaagggaacggacuugaagggcuaagcggggaaagaagacccuguugaguuugacuccagucuggcucugugcggcgacuuuggagguguaguauagguggaagcgcaagcucaaaugaaauaccaccacucggaacguugcuucacuuaucgaaugaagagaccaaugguuguuuugcgcagucuucgggcugugcgccgucuaggcugggcauaauugugguguuucuuucaccgccacgggagggguguugguuuuuuauccuccucuccguuucuccuuuucucucuuucucccuuuuuuugggcguuugaggguuggugacccgugggcgcccacgcgugcggaacuacugcgccaacggggugggaacuuuucguuucuucuccggagucuuguuucgagacaucugccagauggggaguuuggcuggggcggcauaucuguuacacgacaacgcagguguccuaaggcgagcucagugggaacagaaaucucacguggaacacaagcguaaaugcuugcuugauuaacgauuuccaguacgaaucgagacugcgaaagcaaggccagcgauccuuugcgaagaacaggaaauaugaacaaaucauaccagaggugucagaauaauuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaaccuagcgccgcagaagacgcuaaggguuggauuguucacccacugacagggaacgugagcuggguuuagaccgucgugagacagguugguuuuacccuacuuggcuggagauugcgaguaaaagauuauccgcgcaaagcggaggcaguccguuuuuuucugggucugccguucgguggcaugugcuuggcgcugccaucuc .........................<<......>>......<<<<<...>>>>>.........<<<<....<<<..<<<<.<<...............<<<<<...............>>>>><..<<<<<<<<<<<..<<<<<.......<<<<<....<<<.<<<....>>>.>>>>>>>>.<<<.<<<<...<.<<<<.............>>>>.>..>>>>.>>>..>>>>>.....<<<....<<<..<<.......>>..>>>>>>.......>>>>>..>>>>>>..>..........<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<.......>>>......>>>>>>>...<<..<<<..<<<<<......<<....<<<<.....>>>>....>>...>>>..>>>>><<<<<<.......>>>>>>....................<<<<<.......>>>>>...........>>....>>.>>>>>>>.....>>.>>>>.>>>.>>>>............<<<<<........>>>>>...<<<<<<..<<<.<<......<<<<.<..<<<..<<<<..<<<<<<<...<<..<<<<<<<<..<............<<<<<...<....>.............>>>>>...>..>>.>>>>>>..>>...<<<<<.....<<<.....<...<<..<<<<<<<<<....>>>>>>>>>..>.>>..<..<<<<........<<<<.......>>>>.<<<<<<<...<......<.......>..>..<<.<<<.<<<<<.....<.<<<...............>>>.>...>>>>>.>>>.>>>>>>>>>..>>>>.....>..................<<<<<.<<<<<<.....>>>>>>.>>>>>...>>>...>>>>>.......>>>>>>>...>>>>...<<.......>>..<<<<<<...........>>>>>>.......<<<<<<<...<<<<<<.......>>>>>>.....<<....((>>....>>>>>>>...<<..<<<<<<.......>>>>>>.>>.<<<....>>>..))........<<<<<..............<<<<.......>>>>.>>>>>..........>>>....>>>>>.......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<.<<<.<<<<<<..<<<<<<<.<......>.>>>>>..>>.<<<.........>>>.....>>>>>..>...>>>..>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>>.......................<<<<<.....>>>>><<<<<<<<<........>>>>.>>>>>....<<<<<<<.<<<<...>>>>>>>>>>>.. .........................((......))......((((.....)))).........((((....((((.((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((.(((((.(......(((((....(((.((((..)))).)))))))).(((.((((...(.((((.............)))).)..)))).))).).)))))...((((....(((..((.......))..)))))).).....)))))..)))))).))..........(((((((((...((.........))...((((((.....((((.....)))).......)))))).].(((.(((..((((((.....((....((((.....))))....))..))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))............(((((........)))))....(((((..(((.((......((((.((((((..(((((.(((((((...(((..((.((.(..((........[...((((..((....))..........].))))...))..)..)).))..)))....((((.....(((..............((((((((....)))))))).........((.((((........((((.......)))).(((((((..(.......((.....))...).((.((...((((.....(.(((...............))).)...))))...)).)))))))))..))))....))...................((((.((.(((.....))).)).))))....)))...))))........)))))))..)))))..(((......[)).)((((((..........]))))))([.(...(((((((...((((((.......)))))).....((][..[[))....)))))))...((...(((((....{..)))))..)).((......)).)]]..]....((((((...............(((.......)))..))))))...)}....))))..)))))).......(..(.(.((((((...((.......))...))))))...))...)........((((.((((((..(((((((.(......).))))..))).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))....))..))).)))))........................(((((.....)))))((((((((..........))).)))))....(.((((..(.((...)).).)))).).. High-resolution cryo-electron microscopy structure of the Trypanosoma brucei ribosome; BETA CHAIN OF THE LARGE RIBOSOMAL SUBUNIT 28S RRNA 4v8m BC 169 5.57 RF00002 URS000017D41D_5691 23395961 0003735 0005840 5691 aacgugucgcgauggaugacuuggcuuccuauuucguugaagaacgcagcaaagugcgauaagugguaucaauugcagaaucauuucauugcccaaucuuugaacgcaaacggcgcaugggagaagcucucucgagccauccccgugcaugccacauuucucagugucg .........................................<<.<<<<<<....>>>>......<<<<......>>.............>>>>......>>....<<.....>><<<<<<<....<<<<....>>>>....>>>>>>>..................... .........................................((((((.[[....[)))...].(((((......]].............)))).)...)))....((.....))(((((((....((((....))))....)))))))..................... High-resolution cryo-electron microscopy structure of the Trypanosoma brucei ribosome; 5.8S RRNA CHAIN OF THE LARGE RIBOSOMAL SUBUNIT 4v8m BD 119 5.57 RF00001 URS000020E902_5691 23395961 0003735 0005840 5691 ggguacgaccauacuuggccgaaugcaccauaucccguccgauuugugaaguuaagcggccacaggccucguuaguacggcgaucagugauggcgcuggaacccgggguguuguacucu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<......<<<<<.<<<....>>>>>>>>.....>>>>>>>>>>>>>>>. (((((((......((((((((.....((.(((...(....)...)))...))....)))))).))((((((......(((((..((....)).))))).....))))))..))))))). High-resolution cryo-electron microscopy structure of the Trypanosoma brucei ribosome; 5S RRNA CHAIN OF THE LARGE RIBOSOMAL SUBUNIT 4v8m BE 210 5.57 URS000080E0E9_5691 23395961 5691 uggaaaugcgaaacacuugccaggugacccauccauccucccacggugagcuuucuuuucaccauaauccacaucuccggccuugcuggggcuugggccucucgacuucucgcguuacucggagcgggggcucaagauugaaaaaugcagcucacccuacguacuguccuuuguugugaguucggcgcauuaaagcaaaaaccuggggug ................<<..........<<...<<<......<..<<<<<.......>>>>>....<<<..<...............><..<<<<..<<....<<<.......>>>....>>..>>>>...>...>>>......<<<..<<.........>>..>>>..>.....>>>.....>>.............>>.......... ((....))........((....(.(...((...(((...(....((((((.......)))))....(((..((.............))((.((((..((....(((.......)))....))..))))..))...)))...........((.........)).....)....)..))).....)).........))..)).......... High-resolution cryo-electron microscopy structure of the Trypanosoma brucei ribosome; SHORT RRNA-I OF THE LARGE RIBOSOMAL SUBUNIT 4v8m BF 73 5.57 URS000080E2E5_5691 23395961 5691 cgaaucgccacuucucuuaucugggugcucugcccgcccuugucggcgcccaguaccuucauuuucacaagau ..................................<<<<......>>>>......................... .....................(............((((......))))......).................. High-resolution cryo-electron microscopy structure of the Trypanosoma brucei ribosome; SHORT RRNA-II OF THE LARGE RIBOSOMAL SUBUNIT 4v8m BG 182 5.57 RF02543,RF02540 URS00006089EF_5691 23395961 0003735 0005840 5691 gugagauugugaagggaucucgcaggcaucgugagggaaguaugggguaguacgagaggaacucccaugccgugccucugguuucuggaguuugucgaagggcaagugcuccgacgcuaucgcacggugguucucggcugaacgccucuaagccagaaaccagucccaagaccgggugcccg ...<<<<<.......>>>>>....<<<<<<....<<<..<<<<<<<<...............>>>>>>>><<<<....<<<<....<<<<<<<<<......>>>>..>>>>>...>>>>...>>>>.<<<<....<<<<...........>>>>....>>>>..>>>.......>>>>>>.. ...(((((.......)))))....((((((....((((.(.(((((......(....).....))))).)(((((...((((....((((((((((....)))))..)))))...))))..))))).((((....(((.............)))....)))).)))).......)))))).. High-resolution cryo-electron microscopy structure of the Trypanosoma brucei ribosome; SHORT RRNA-III OF THE LARGE RIBOSOMAL SUBUNIT 4v8m BH 135 5.57 URS000080DEE2_5691 23395961 5691 uuuugucccucuccaaacgagaguacaugcaugggcuggcaugagcggcacgcuccacgaccguggggcucgaggggcacuuuacgucccgaggcgcugaaccuugaugcuuggaauuucaugcucagggacuuu ...........................<<..<..<...<......<<....<<<<<<<....>>>>>>>......<<<.<.............>.>>>......>>.....>......>...>..>>........ .....(....(.......)........((.....(...(......((....(((((((....))))))).......(...................).......)).....)......)......))..)..... High-resolution cryo-electron microscopy structure of the Trypanosoma brucei ribosome; SHORT RRNA-IV OF THE LARGE RIBOSOMAL SUBUNIT 4v8m AA 2227 5.57 RF01960,RF01959,RF00177 URS00003D1DA0_5691 23395961 0003735 0005840 5691 gaucugguugauucugccaguagucauaugcuuguuucaaggacuuagccaugcaugccucagaaucacugcauugcaggaaucugcgcauggcucauuacaucagacguaaucugccgccaaaauuuugcggucuccgcauuacuggauaacuuggcgaaacgccaagcuaauacaugaaccaaucggacgcucucuuuuucuaugucgcggcuuguguuuacgcacuugucguggcgaugagacguccagcgaaugaaugaaauuagaaccaacgccuccacccgggggcaguaacacucagacguguugacucaauucauuccgugcgaaagccgagccuuuuugcucggcgucuacugacgaacaacugcccuaucagccagugauggccguguaguggacugccauggcguugacgggagcgggggauuaggguucgauuccggagagggagccugagaaauagcuaccacuucuacggagggcagcaggcgcgcaaauugcccaaugucgaaaaaauacgaugaggcagcgaaaagaaauagagccgaccgugcccuagugcaugguuguuuucaaugggggauacucaaacccauccaauaucgaguaacaauuggaggacaagucuggugccagcacccgcgguaauuccagcuccaaaagcguauauuaaugcuguugcuguuaaaggguucguaguugaacugugggccacguaguuuugugccgugccagucccguccaccucggacguguuuugacccacgcccucguggcccgugaacacacucagauacaagaaacacgggagcgguuccuccucacuuucacgcaugucaugcaugcgagggggcguccgugaauuuuacugugaccaaaaaagugcgaccaaagcagucugccgacuugaauuacaaagcaugggauaacgaagcaucacaccguuucggcuuuuguugguuuuagaaguccuugggagauuauggggccgcgugccuugggucgguguuucgugucucauuuuuguggcgcgcacauucggcucuucgugauguuuuuuuacauucauugcgacgcgcggcuuccaggaaugaaggaggguaguucgggggagaacguacuggugcgucagaggugaaauucuuagaccgcaccaagacgaacuacagcgaaggcauucuucaaggauaccuuccucaaucaagaaccaaaguguggggaucaaagaugauuagagaccauuguaguccacacugcaaaccaugacacccaugaauuggggaacaucauugggugcccguguggcggccuuuugugccgacccucggccccaauuuauuuaucaauuuacgugccuauucuaucacccccgguucccucuuuugagguucuuccgggguuuuuuacgggaauauccucagcacguuucuuacuucuucacgcgaaagcuuggagguuacagucucaggggggaguacguucgcaagagugaaacuuaaagaaauugacggaauggcaccacaagacguggagcgugcgguuuaauuugacucaacacggggaacuuuaccagauccggacagggugaggauugacagauggaguguucuuucucgauccccugaaugguggugcauggccgcuuuuggucgguggagugauuuguuugguugauuccgucaacggacgagauccaagcugcccaguaggugccgggauugcagucccuccggcggggauuuuuuccccaacgguggucgucauccuucuuuuuacaggccccuucucugcgggauuccuugcuuuucgcgcaaggugagauuuugggcaacagcaggucugugaugcuccucaauguucugggcgacacgcgcacuacaaugucagugagaacaagaguccgagcggcacuucacaaugucgcucccgcuugaucaaaagagcggggaaaccacggaaucacguagacccacuugggaccgaguauugcaauuauuggucgcgcaacgaggaaugucucguaggcgcagcucaucaaacugugccgauuacgucccugccauuuguacacaccgcccgucguuguuuccgaugauggugcaauacaggugaucggaccgucgcucgucucgggcgaccgaaaguucaccgauauugcuucaauagaggaagcaaaagucguaacaagguagcuguaggugaaccugcagcuggaucauuu ...<<<<..{.[[[[.>>>><<<..<<<<<<....<...........<<..<<<..<<..........<<<.....>>>......>>......<<........<<<..<...<<....<..<......<<<<<...>>>>>....<<.....<<<<<<.....>>>>>>......>>..........<<<<<.<<................<<<..<<<......>>>..>>>..........>>>>>>>...<<<<<<<<........(((((..<<<<........>>>>.........................>>>>>>>>.........<<<<<<<......>>>>>>>...>..>...>>.>..>>>.<<<....<<.....<<<<<.<.........>.>>>>>.>>......>>>..<<<.<<.<....>.>>....>>>.>>.<<.<<<..........>>>.>>.<<<......>>>...>>>.>>.........<<<....<<<..........>>>..>>>........>.....<<<..<<<<<<<<......>>>>>>>>...>>>......<.....................>..........<<<<<((......<<<..........))..........>>>.>>>>>..>>>>>>.>>>.........<<<[[.....<<<<...<<<.......<<<<<<<.......................<<<<.......>>>>...................>>>>>>>....................<<<.<<<<<<......<<<.............<<<<<<...>>>>>>...>>>...>>>>>>..>>>.<.<<<<.<.....................<........>............>>>>>...>.................<....<<<<<...)))))...>>>>>.....>.......<<<<<<<<<<<.<<..<......<<<<.................>>>>....>....>>....<<<<<<<<............>>>>>>>>.>>>>>>.>>>>>...........<<...<.<<...<<<<<..<<.<<<<<<<<....<........>.......>>>>>>>.>>>........<<....>>..>>>>>..>>.>....>>...>>>...>>>>...<<<<<<<..<.<...<<<<.........>>>>...>>>>>>>>>.........<<<.<<....<..<<<<<<<<...<<<<<<.<<<.<.<.<<<<<<.......>>>>.>>>.>>>>>>>>>>..<<<....>>>....<<<<..<<<<<.....<<<<<<...<<<<....>>>>.....>>>>>>.........>>>>>.......>>>>>>>>>>>>..>......<<..]]>>.....>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..]]]].}<<<<<.<<<<<<<..<<..<<<<<..<<.<<<<<........<<........>>..........<<<<<......<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<.....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<..<<.....<........<<<<.......<<..<<<..<<<<<.....>>>>>..>>>.>>......>>>>....................>...>>....<<<<<<.......>>>>>>........>>>>.....>>.>>>.....>>>>>>>.......>>>>>......>>>>>.>>.....<<<.<<...............<<<<<<<........>>>>>>>....<<<<.<<....>>.>>>>................>>.>>>...........<<<.<<..........>>.>>>...........>>>>>.....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>.......<<...<<<<<<<...<<.<<<.<<<<<<..<<<<......<.<<<<<<<<...>>>>>>>>.>......>>>>..>>>>>>.>>>.>>...>>>>>>>....>>.........<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[[.))))((((.((((((...(((...((.....(((.(((..((....(.....((.......))....).))......(((.......(((......((....(..(......(((((...)))))....((.....((((((.....))))))......))..........(((((.((................(.(...(........)...).)..........)))))))...((((((((....<...[[[[[..((((.(....).))))................(......).)))))))).........(((((((......)))))))...)..)...))....))).(((....(((....(((((.((.......)).))))))))......)))..(((.(.((....)).)....)))))).((.(((..........))).)).((((....))))...)))))).).......(((...(.((..........))..))))..)....))).....((.(((((((((......)))))))))..))....(.(.......................)......)..((((([[....(..(((.....((..]])).......))).))))))..)))))))))).........((({{...(.((((...(((..(....((((((((.......(..............((((.......))))..............)...)))))))).....................((.(((((.....(.(((.............((((((...))))))...))).)..)))))..))......((.(.....................((......))............)))....................(..(...((((...>.]]]]].....))))....)..)....((((.((((((((...(.....(.(((.................))).)...).....)....(((.((((............)))).))))))))))..))))...........(((....((...(.(((..((..((((..(...((........))......)..))))..))........((....)).).)).)..)).....))).).)))...))))....((((((....(...((((.........))))...).))))))..........(((.((............(((...((((((.(((.(.(.((((((.......)))).))).))))))))))..(((....)))....((((.(((((......((((((...((((....)))).....))))))..........)))))......)))))))............(.((..}})))....)).....))))))).(((......((((....))))....)))..]]]].](((((.(((((((..((..(.(((..((.(((((((.......(........)...........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))....((......))....)).))).....((((.(....(.......(...((.(......((..(((..(((((.....)))))..))).)).....).))...............).......)..)..(.((((((.......))))))....)..)))).....))).))).....).))))).....).)))))...)).))))).)).(...(((..(........(......(((((((........)))))))....((.(.((....)).).)).......)........)..)))......(....((...(..........)...)).....)..)..))).).....(((.(((.........))).)))......))...)))))))))).))..(.(..((.(.((((((((..(..(((.(((((((.((((..(...(.((((((((...)))))))).)...)..))))).)))))).)))..)..))))))))..).))...)..)..(((((((((....)))))))))......... High-resolution cryo-electron microscopy structure of the Trypanosoma brucei ribosome; 18S RRNA OF THE SMALL RIBOSOMAL SUBUNIT 4v8m AB 73 5.57 RF00005 URS000035465A_5691 23395961 0030533 0006412 5691 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggca <<<.......<<..........>>...<<<<<.....>>>>>.......<<...........>>....>.>>. ((........(............)...(((((.....))))).......((((.......))))......)). High-resolution cryo-electron microscopy structure of the Trypanosoma brucei ribosome; E-SITE TRNA 4v8n AA 1504 3.1 RF00177,RF01959,RF01960 URS000080E226_300852 23542153 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<.........>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>....<<<<.<<<<<....>>>>>.>>>>...<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<.<<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<....<<<<<<....>>>>>>.....<.......>.....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<....<<.....>>.>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<...<<<<....>>>>...>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((.((...........)).)))).)))))......(((......((((((((..((...((((.(..(((((....((((.(....).)))).....)))))....((((.(((((....))))).))))...((((...))))...)))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((........)).))))).)).))))))..((((......((((....)))).....))))....(((((...(.....((.......))......)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(.((.(((((...))))).)).)...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((.(..((((((((((......((........))..........(((((((..(.....(((......((.(((....))).)).....................)))..).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..((..............).)...))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..).))).....(((((((..........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. The crystal structure of agmatidine tRNA-Ile2 bound to the 70S ribosome in the A and P site.; 16S RRNA 4v8n AV 78 3.1 RF00005 URS000080E382_2238 23542153 0030533 0006412 2238 gggcccuuagcuuagucugguuaaagcgaucggcunauaaccgauugggcgcugguucgaauccggcagggcccacca <<<<<<<...<<<..........>>>.<<<<<<.......>>>>>>....<<<<<.......>>>>>>>>>>>>.... .((((.(....((..........))..((((((.......))))))....(((((.......)))))).))))..... The crystal structure of agmatidine tRNA-Ile2 bound to the 70S ribosome in the A and P site.; E-SITE TRNA ILE2 AGMATIDINE OR P-SITE TRNA ILE2 AGMATIDINE 4v8n AW 78 3.1 RF00005 URS000080E067_2238 23542153 0030533 0006412 2238 gggcccuuagcuuagucugguuaaagcgaucggcucauaaccgauugggcgcugguucgaauccggcagggcccacca .<<.<<....<<............>>.<<<<<<.......>>>>>>....<<<<<.......>>>>>.>>..>>.... .((.........(...........)...(((((.......))))).......(((.......))).......)).... The crystal structure of agmatidine tRNA-Ile2 bound to the 70S ribosome in the A and P site.; A-SITE TRNA ILE2 AGMATIDINE 4v8n AX 12 3.1 23542153 562 aaaauaauaaaa ............ ............ The crystal structure of agmatidine tRNA-Ile2 bound to the 70S ribosome in the A and P site.; MRNA 4v8n AY 78 3.1 RF00005 URS000080E382_2238 23542153 0030533 0006412 2238 gggcccuuagcuuagucugguuaaagcgaucggcunauaaccgauugggcgcugguucgaauccggcagggcccacca .<<<<<<..<<<<..........>>>><<<<<<.......>>>>>>....<<<<<.......>>>>>>>>>>>..... ...((.(....((..........))..((((((.......)))))).....((((.......)))).).))....... The crystal structure of agmatidine tRNA-Ile2 bound to the 70S ribosome in the A and P site.; E-SITE TRNA ILE2 AGMATIDINE OR P-SITE TRNA ILE2 AGMATIDINE 4v8n BA 2848 3.1 RF02540,RF02541,RF00002 URS000080E0F3_300852 23542153 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucgggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgggccgcacgcggcccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccagucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<....>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>.....<<<<<<<<<....<<<...<<<<..<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>...>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.......<<<<<....>>>>>......>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<....>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<.........>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (........((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((((((((..).))))))))....(((((((((......((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))..))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...........................)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((.(.(..(((......)))...))..)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((................)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.((...{{....))))))(((...((((((((((.(((((.((.....))))))).).....)))))))))..)))(.....(......).......))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((((.......)))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((..((.((((........[...((((..(((......((.(((((....))))).))...)))..........].))))...)))).))..)))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))...(.........).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))......) The crystal structure of agmatidine tRNA-Ile2 bound to the 70S ribosome in the A and P site.; 23S RIBOSOMAL RNA 4v8n BB 119 3.1 RF00001 URS00005AB4A7_300852 23542153 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>> ..(((((((((....(((((..(....(((((((...(.....)...))))..)))...)..))).))(((.......((.(((((....))))).)).......))).))))))))). The crystal structure of agmatidine tRNA-Ile2 bound to the 70S ribosome in the A and P site.; 5S RIBOSOMAL RNA 4v8n CA 1504 3.1 RF00177,RF01959,RF01960 URS000080E226_300852 23542153 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<.........>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>....<<<<.<<<<<....>>>>>.>>>>...<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<.<<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<....<<<<<<....>>>>>>.....<.......>.....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<....<<.....>>.>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<...<<<<....>>>>...>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<<..>>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((.((...........)).)))).)))))......(((......((((((((..((...((((.(..(((((....((((.(....).)))).....)))))....((((.(((((....))))).))))...((((...))))...)))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((........)).))))).)).))))))..((((......((((....)))).....))))....(((((...(.....((.......))......)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(.((.(((((...))))).)).)...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((.(..((((((((((......((........))..........(((((((..(.....(((.....(((.(((....))).)))....................)))..).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..((..............).)...))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..).))).....(((((((..........)))))))......))...)))))))))).))..(.(..((...((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))....))...)..)..(((((((((....)))))))))}.. The crystal structure of agmatidine tRNA-Ile2 bound to the 70S ribosome in the A and P site.; 16S RRNA 4v8n CV 78 3.1 RF00005 URS000080E382_2238 23542153 0030533 0006412 2238 gggcccuuagcuuagucugguuaaagcgaucggcunauaaccgauugggcgcugguucgaauccggcagggcccacca <<<<<<<...<<<..........>>>.<<<<<<.......>>>>>>....<<<<<.......>>>>>>>>>>>>.... .((((((...(((..........))).((((((.......))))))....(((((.......)))))))))))..... The crystal structure of agmatidine tRNA-Ile2 bound to the 70S ribosome in the A and P site.; E-SITE TRNA ILE2 AGMATIDINE OR P-SITE TRNA ILE2 AGMATIDINE 4v8n CW 78 3.1 RF00005 URS000080E067_2238 23542153 0030533 0006412 2238 gggcccuuagcuuagucugguuaaagcgaucggcucauaaccgauugggcgcugguucgaauccggcagggcccacca .<<.<<....<<............>>.<<<<<<.......>>>>>>....<<<<<.......>>>>>.>>..>>.... .((.........(...........)...(((((.......))))).......(((.......))).......)).... The crystal structure of agmatidine tRNA-Ile2 bound to the 70S ribosome in the A and P site.; A-SITE TRNA ILE2 AGMATIDINE 4v8n CX 12 3.1 23542153 562 aaaauaauaaaa ............ ............ The crystal structure of agmatidine tRNA-Ile2 bound to the 70S ribosome in the A and P site.; MRNA 4v8n CY 78 3.1 RF00005 URS000080E382_2238 23542153 0030533 0006412 2238 gggcccuuagcuuagucugguuaaagcgaucggcunauaaccgauugggcgcugguucgaauccggcagggcccacca .<<<<<<..<<<<..........>>>><<<<<<.......>>>>>>....<<<<<.......>>>>>>>>>>>..... ...((.(..((((..........))))((((((.......)))))).....((((.......)))).).))....... The crystal structure of agmatidine tRNA-Ile2 bound to the 70S ribosome in the A and P site.; E-SITE TRNA ILE2 AGMATIDINE OR P-SITE TRNA ILE2 AGMATIDINE 4v8n DA 2848 3.1 RF02540,RF02541,RF00002 URS000080E0F3_300852 23542153 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucgggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgggccgcacgcggcccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccagucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<....>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>.....<<<<<<<<<....<<<...<<<<..<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>...>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.......<<<<<....>>>>>......>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<....>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<.........>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (........((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((((((((..).))))))))....(((((((((.......(...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)...))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...........................)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((.(.(..(((......)))...))..)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((................)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.((...{{....))))))(((...((((((((((.(((((.((.....))))))).).....)))))))))..)))(.....(......).......))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((((.......)))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((.....((((........[...((((..((.......((.(((((....))))).))....))..........].))))...)))).....)))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))...(.........).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))......) The crystal structure of agmatidine tRNA-Ile2 bound to the 70S ribosome in the A and P site.; 23S RIBOSOMAL RNA 4v8n DB 119 3.1 RF00001 URS00005AB4A7_300852 23542153 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>> ..(((((((((....(((((..(....(((((((...(.....)...))))..)))...)..))).))(((.......((.(((((....))))).)).......))).))))))))). The crystal structure of agmatidine tRNA-Ile2 bound to the 70S ribosome in the A and P site.; 5S RIBOSOMAL RNA 4v8o AA 1504 3.8 RF00177,RF01959,RF01960 URS000080E226_300852 21903932 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<.<<<.<........>>>>.>>>.>>>>>......<<.......<<<<<<<...<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>....<<<<.<<<<<....>>>>>.>>>>...<<<<...>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<.<<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<.....>>.>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<<..>>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..((((((((.....((..(((..(((..((.(....(.............)....).)))))......(((......((((((((..((...(((((((.(((.(....((((........)))).....).)))....((((.(((((....))))).))))...((.(...).)).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...))).)).......(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(.....(((.....)))......)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......(..........)..........(((((((..(...((........(((((((....))))))).(..............)......))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.((((((....(..............)......))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((..........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Crystal structure of the hybrid state of ribosome in complex with the guanosine triphosphatase release factor 3; 16S RRNA 4v8o AV 77 3.8 RF00005 URS000041AF00_83333 21903932 0030533 0006412 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .(((((...((((......[..)))).(((((.......))))).....(.((...].....)).).)))))..... Crystal structure of the hybrid state of ribosome in complex with the guanosine triphosphatase release factor 3; PE HYBRID STATE TRNA FMET 4v8o BA 2901 3.8 RF02540,RF02541,RF00002 URS000080E1F7_300852 21903932 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgggccgcacgcggcccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgcggcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu .<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<....>>>>>>.>>....<<<<<.....<......>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<..<<<<.<<<....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>...>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>.....<........>...<<<<<<....<<<<<<<<<<<<...<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....<<<<<<<....>>>>>>>.....>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<.<........<<<<<..<....<<.........>>....>..........<<......>>...>>>>>....>.>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[....>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>>....<<<<....>>>>......>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>>.<<<<<.......>>>>>.........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<..<...<<<......<<<<<<<<....>>>>>>>>...>>>.............>.>...>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<.<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>..>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<..]]].>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<.......>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>. .........((((((((((.....(((..(((((((((((.......(.((((.[[..[[.))).....((.(((...(((]]..]].)))......))).))...).)....(((....)))((((((((....)))))))).((((((....))))))..)...((((((.....(...[..)......))))).).........((....))....((((.....((.]...))....))))....((([...((((((((.....))))))))....(.(((((((((.....(....(((((..(((..((...((((........))))[[(...).(((.....]])))...))....)))...)))))...).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((.(....).))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..((....(((.....)))....))...((....))..((((.....))))...........................)))))))))))))..((.(...((((((.....((((((((((.(((....((((((......))))))....[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((.(....(((((....)))))(((((((((.(...(((((((((...(((...((((((((.(....(((......)))....)..))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((.(((.....(.....(...((((((..(......{.........................................(.........)...........)..))))))..)..........]]].)....))).))))))...)))))))((((((.(.....).))))))....).))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....)))))).......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((..((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.((...{{....))))))(((...((((((((((....(..((.....)).)....).....)))))))))..)))(...((.(....).)).....))))))...)))..)))))(..).....))))...))...))))))))))).))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))(((.((((((.........)))))).)))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).))))))......)....(((((.....]..)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((.((....(.((.(...........(..(...((.......(.(((..........))).)....)).............).)...).)).)....)).)))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...(.((..((....{...))..)).).((......)).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..)))))).......((((...((((((...((.......))...))))))....))).)........((((.((.(((..(((((((((......))))))..))).(((((.....))))).....))).)..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[....((((((....(((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).)))...]....)))))).....(.......)......(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....... Crystal structure of the hybrid state of ribosome in complex with the guanosine triphosphatase release factor 3; 23S RIBOSOMAL RNA 4v8o BB 119 3.8 RF00001 URS00005AB4A7_300852 21903932 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<<....<<<<<<<.....<<<<<<...............>>>..>>>....>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>> .((((((((((........(..(....(((((((...(.....)...))))..)))...)..).....(((.......((.(((.(....).))).)).......))).)))))))))) Crystal structure of the hybrid state of ribosome in complex with the guanosine triphosphatase release factor 3; 5S RIBOSOMAL RNA 4v8p A1 3119 3.52 RF02540,RF02543 URS000059BB66_5911 22052974 0003735 0005840 5911 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........................<<<<<<.....<......>......>>>>>.>...{.....<<....>>..<<<<<......<<.....>>.....>>>>>..[[[...........<<<<..<<<.....>>>..>>>>.............<<<<<..<<<...<<<.<<<<<<<<<<......<<<<......>>>>.((......<<<.....))>>>.......>>>>>>>..>>>>>>...>>>..>>>>.>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]....}.............................<<....>>...............<<<<....>>>>................................<.<<<<<<<....<<...<<<<.<<<<<.....<<<....<<<<<.<<..<<<<...<<<<<<.<......>>>>>>>..>>.>>...>>>>>>>....>>>....>>>>>.>>>>..<<<<<<<<.<<<<<<<.<<<<<<......<<<..<<<<..<<<....>>>.>>>>...>>>....>>>>>>.>>>>>>>.....<<<....>>>.>>>>>>>>...>>..>>>>>>>.>..<<<<........>>>><<<<<<...<<<<.<<<<<<<<<..<<<...<<<<......>>>>...>>>...<<....>>........<<<<<...<<<....>>>....>>>>>.<<<<<<<....<<<...>>>....>>.>>>.>>....>>>>>>>>>.>>>>.<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>(><<<<<<<<<.....<<<.<<<<<<<<<...<<<....<<<....<<<..<<<<<<<<<...>>>>>>>>>>>>....>>>..>.>>...>>>>>>>...<<<.<<<<<<..........>>>>>>>>>....>>>>>..>>>>>>>.>>).<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<....<<<(((.....<<<<<<......<..........<<<.<<<<<<<<<........<<<<..>>>>....>>>>>>>>>>>>..........))).>....>>>>>>.>>>....>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<<<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<..<<<......>>>..........<<<<<<....>>>>>>...>>>....>>>..<<<<<........>>>>>))<<<<.<<<<..<<...<<<....>>>.......<<<<<<...<<<<.<<<<<<<<<<<<<<<<<<.......>>>>>><...<<<<<...<<<<<<<....<<<<...>>>>....>>>.>>>>....>>>>>....><<<<<<<.>>>>>>>>>>>.>.>>>>>>>.>>>>.........>>>>>>.........>>..>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<...............>>>>><<.<<<<<<...>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<......>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....(((((..{{{.{{......[[[[.{{[[[[..<<<<<..<<<<<<<..<<<<<<<<<<.>>>>>>>>>>...<<<<<.....<<<<..<<<<<....>>>>>............<<<<<.....>>>>>..>>>>..>>>>>.....>>>>>>>...>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......(((((.[.(((.>>>>>>)))].)))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.))))).....<<<<<<<<..<<<<.<<<<<<<<...............>>>>>>>><<<<<...<<<<....<<<<<<<<<<....>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.....<<<<<<<<......<<................>>......<<<<...<<<...<<<<......>>>>..>>>...>>>>...............>>>>>>>>....<<<<<<<<...................<<<<<<<<.<<<....<<<.<<..<<<<......>>>>..>>>>>...>>>....>>>>>.>>>..>>>>>>>> ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((((..(((.....)))..))))....)........(((((..(((...(((.((((((((((....({((((......)))))[[(...).(((....}]]))).......)))))))..))))))...)))..)))).)...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))..........).....................(.(((((((....((...((((.(((((.....(((....(((((.(((.((((...((((((.(......)))))))..)).)))..)))))))....)))....))))).))))..((((((((.(((((((.((((((......(((..((((..(((....))).))))...)))....)))))).))))))).....(((....))).))))))))...))..))))))).).<((((........))))((((((....(((.(((((((((..(((...((((......))))...)))...((....))........(((((...(((....)))....))))).(((((((....(((...)))....)).))).))....))))))))).)))..((.(...((((((.....((((((((((.(((....(((((((....)))))))....<)))...(((..((.((........)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)(((((((((.....(((.((((((((....(((....(((..(.(((..(((((((((...)))))))))))).)..)))..)).)....))))))...(((.((((((..(......))))))))))....)))))..))))))).))..((((.(((((.....))))).))))....(((......)))...((((((....((([[[...(.((((((......(..........(((.((((((((((.......((((()))))...)))))))))))))..........]]].)....))))))))))....))))))(((((((((.........)))))))))....))))))(.((((((((((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((..(((((((...((.....)).))))))....[[(((.((...(((..(((......)))......(...((((((....)))))).).)))....))...(((((........)))))]]((((.((((..((...(((....))).....[[((((((...((((.((((((((((((((((((...{{..))))))(...(((((...((((((.....(((.....))).....)).))))....)))))....)(((((((.))))))))))).).))))))).))))(...)....)))))).........))..)))))))).))).))).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.((((((...)))))).))(...).......(((((((((.>.((.........))...(((((((....((((....))))......))))))).].(((.(((..((((((.(...((.....(((......))).....)).)))))..)))))((((((.......))))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((..(((((((..((((((((.(.).))))))))...(((((.....((((..(((((....)))))........]]..((((((..).)))))..))))..))))).....)))))))...)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..(((((...{.)))))..))).(((....))).))]]].].....(((((.(.(((.]]]]]])))).)))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(((((((((......))))))..))).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))....))..))).))))).....((((((((..((((.(((((((......(....).....)))))))(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.............))))...)))).))))....))))))))...(.((((((((....(.((................)))...(.((((...(((...((((......))))..)))...)))))..............)))))))))....((((((((..(.......)..)....((((((((.(((....(((.((..((((......))))..)))))...)))....))))).)))..))))))). T.thermophila 60S ribosomal subunit in complex with initiation factor 6.; 26S RRNA 4v8p B2 154 3.52 RF00002 URS00003890D2_5911 22052974 0003735 0005840 5911 agaaaauuuucaacgguggauaucuagguucccgugacgaugaagaacgcagcgaaaugcgauacgcaaugcgaauugcagaaccgcgagucaucagaucuuugaacgcaagugguggagguguaaaaaccuucauguuuguuucaguguggaa ............................................<<<<<<.<<.....>>>.....(.<<<......>>............>>>..)...>>>....<<.....>><<<<<<......>>>>>>.................... ............................................((((((.[[.....))).....(.((((.....]]..........).)))..)...)))....((.....))(((((........))))).................... T.thermophila 60S ribosomal subunit in complex with initiation factor 6.; 5.8S RRNA 4v8p B3 120 3.52 RF00001 URS000057A4D1_5911 22052974 0003735 0005840 5911 guugucggccauacuaaggugaaaacaccggaucccauucgaacuccgaaguuaagcgccuuaaggcuggguuaguacuaaggugggggaccgcuugggaagucccagugucgauagccu <<<<<<<<.....<<<<<<<......<<<<<<............>>>>..>>.....>>>>>.>><<<<<<......<<<<<..<<....>>.>>>>>.....>>>>>>.>>>>>>>>.. (.(((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......(((((..((....)).))))).....))))))))))))).).. T.thermophila 60S ribosomal subunit in complex with initiation factor 6.; 5S RRNA 4v8p C2 154 3.52 RF00002 URS00003890D2_5911 22052974 0003735 0005840 5911 agaaaauuuucaacgguggauaucuagguucccgugacgaugaagaacgcagcgaaaugcgauacgcaaugcgaauugcagaaccgcgagucaucagaucuuugaacgcaagugguggagguguaaaaaccuucauguuuguuucaguguggaa ............................................<<<<<<.<<.....>>>.....(.<<<......>>............>>>..)...>>>....<<.....>><<<<<<......>>>>>>.................... ............................................((((((.[[.....))).....(.((((.....]]..........).)))..)...)))....((.....))(((((........))))).................... T.thermophila 60S ribosomal subunit in complex with initiation factor 6.; 5.8S RRNA 4v8p C3 120 3.52 RF00001 URS000057A4D1_5911 22052974 0003735 0005840 5911 guugucggccauacuaaggugaaaacaccggaucccauucgaacuccgaaguuaagcgccuuaaggcuggguuaguacuaaggugggggaccgcuugggaagucccagugucgauagccu <<<<<<<<.....<<<<<<<......<<<<<<............>>>>..>>.....>>>>>.>><<<<<<......<<<<<..<<....>>.>>>>>.....>>>>>>.>>>>>>>>.. (.(((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......(((((..((....)).))))).....))))))))))))).).. T.thermophila 60S ribosomal subunit in complex with initiation factor 6.; 5S RRNA 4v8p D1 3119 3.52 RF02540,RF02543 URS000059BB66_5911 22052974 0003735 0005840 5911 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T.thermophila 60S ribosomal subunit in complex with initiation factor 6.; 26S RRNA 4v8p E2 154 3.52 RF00002 URS00003890D2_5911 22052974 0003735 0005840 5911 agaaaauuuucaacgguggauaucuagguucccgugacgaugaagaacgcagcgaaaugcgauacgcaaugcgaauugcagaaccgcgagucaucagaucuuugaacgcaagugguggagguguaaaaaccuucauguuuguuucaguguggaa ............................................<<<<<<.<<.....>>>.....(.<<<......>>............>>>..)...>>>....<<.....>><<<<<<......>>>>>>.................... ............................................((((((.[[.....))).....(.((((.....]]..........).)))..)...)))....((.....))(((((........))))).................... T.thermophila 60S ribosomal subunit in complex with initiation factor 6.; 5.8S RRNA 4v8p E3 120 3.52 RF00001 URS000057A4D1_5911 22052974 0003735 0005840 5911 guugucggccauacuaaggugaaaacaccggaucccauucgaacuccgaaguuaagcgccuuaaggcuggguuaguacuaaggugggggaccgcuugggaagucccagugucgauagccu <<<<<<<<.....<<<<<<<......<<<<<<............>>>>..>>.....>>>>>.>><<<<<<......<<<<<..<<....>>.>>>>>.....>>>>>>.>>>>>>>>.. (.(((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......(((((..((....)).))))).....))))))))))))).).. T.thermophila 60S ribosomal subunit in complex with initiation factor 6.; 5S RRNA 4v8p F1 3119 3.52 RF02540,RF02543 URS000059BB66_5911 22052974 0003735 0005840 5911 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T.thermophila 60S ribosomal subunit in complex with initiation factor 6.; 26S RRNA 4v8p G2 154 3.52 RF00002 URS00003890D2_5911 22052974 0003735 0005840 5911 agaaaauuuucaacgguggauaucuagguucccgugacgaugaagaacgcagcgaaaugcgauacgcaaugcgaauugcagaaccgcgagucaucagaucuuugaacgcaagugguggagguguaaaaaccuucauguuuguuucaguguggaa ............................................<<<<<<.<<.....>>>.....(.<<<......>>............>>>..)...>>>....<<.....>><<<<<<......>>>>>>.................... ............................................((((((.[[.....))).....(.((((.....]]..........).)))..)...)))....((.....))(((((........))))).................... T.thermophila 60S ribosomal subunit in complex with initiation factor 6.; 5.8S RRNA 4v8p G3 120 3.52 RF00001 URS000057A4D1_5911 22052974 0003735 0005840 5911 guugucggccauacuaaggugaaaacaccggaucccauucgaacuccgaaguuaagcgccuuaaggcuggguuaguacuaaggugggggaccgcuugggaagucccagugucgauagccu <<<<<<<<.....<<<<<<<......<<<<<<............>>>>..>>.....>>>>>.>><<<<<<......<<<<<..<<....>>.>>>>>.....>>>>>>.>>>>>>>>.. (.(((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......(((((..((....)).))))).....))))))))))))).).. T.thermophila 60S ribosomal subunit in complex with initiation factor 6.; 5S RRNA 4v8p H1 3119 3.52 RF02540,RF02543 URS000059BB66_5911 22052974 0003735 0005840 5911 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T.thermophila 60S ribosomal subunit in complex with initiation factor 6.; 26S RRNA 4v8q AA 2901 3.1 RF02540,RF02541,RF00002 URS000080DD86_300852 22422985 0003735 0005840 300852 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<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<....>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<..<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>...>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....<<<<<<<....>>>>>>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<........>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<..<........<<<<<.<<...<<<.........>>>...>>.........<<......>>...>>>>>....>..>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<............<<<...<<<......<<<<<<<<<..>>>>>>>>>...>>>............>.>>...>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<.......>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> .........((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((.(....).)))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...(((((.(.......).)))))....{.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).))))....(((((((((.[.....)))))))))....}.(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).........(.......).........)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((.(.((..(........)...)))..)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..........{....((.(.(...(...........)...).)......................))...........))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((.(((((...((((....(((((.(((..(((((.((((.((...{{....))))))(((...(((((((..(.(((((.((.....))))))).).......)))))))..)))(....(((....)))......))))))...)))..)))))(..).....))))...))...))).))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((.........))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((.((..(...(((...............(...(((......(.(....(....)....).)...)))............).......)))...)..)).)))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...((.((((.(.(((((.........)))))...).((][.[[[))....)))).))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))...................(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....... Complex of SmpB, a tmRNA fragment and EF-Tu-GDP-Kirromycin with the 70S ribosome; 23S ribosomal RNA 4v8q AB 119 3.1 RF00001 URS00005AB4A7_300852 22422985 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>> ..(((((((((......(((.((....(((((((...(.....)...))))..)))...)).)))...(((.......((.(((((....))))).)).......))).))))))))). Complex of SmpB, a tmRNA fragment and EF-Tu-GDP-Kirromycin with the 70S ribosome; 5S ribosomal RNA 4v8q BA 1504 3.1 RF00177,RF01959,RF01960 URS000080DFBB_300852 22422985 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacugggaagaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<.<........>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>....<<.....>>....>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<....<<.....>>.>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<..<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>..>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((..((..(((..((.((.(((.............))).)).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.((((......)))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)).))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((.....)))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..(((((((.((......((........))........(.(((((((..(...((((......(.(..((....))..).).....................))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...(..............).....)))))))..(..(((.(....).))).....)..)))).....).).)))...)).)))))....)))))))).[))..))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.(..(.(((..(((((((((((((...(.((((....(.(....).).)))).)..)))))))))))))..))).)..)..).))...)..)..(((((((((....)))))))))}.. Complex of SmpB, a tmRNA fragment and EF-Tu-GDP-Kirromycin with the 70S ribosome; 16S ribosomal RNA 4v8q BV 77 3.1 RF00005 URS000041AF00_83333 22422985 0030533 0006412 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Complex of SmpB, a tmRNA fragment and EF-Tu-GDP-Kirromycin with the 70S ribosome; E-SITE or P-SITE TRNA FMET 4v8q BW 77 3.1 RF00005 URS000041AF00_83333 22422985 0030533 0006412 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((....(...........)...(.(((.......))).).........(.......)....))))))..... Complex of SmpB, a tmRNA fragment and EF-Tu-GDP-Kirromycin with the 70S ribosome; E-SITE or P-SITE TRNA FMET 4v8q BY 62 3.1 RF00023 URS000080E208_300852 22422985 0006401 300852 gggggugaaacggucucgacagggccuuuggacguggguucgacucccaccaccuccaccaA <<<<<<<............<<<<...>>>>...<<<<<.......>>>>>>>>>>>>..... (((((((.....[......(((((.)))))...(((((..]....)))))))))))).... Complex of SmpB, a tmRNA fragment and EF-Tu-GDP-Kirromycin with the 70S ribosome; TMRNA DELA 4v8t 5 3150 8.1 RF02540,RF02543 URS000061F377_559292 23142985 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacauggcugggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<.<<<<<..<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>......>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<<...........<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<<..<<<<<<.....>>>>>>>>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<<.....>.>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>.>>>>>..<<<<.....<<<<<<<.<<...............<<<<<...............>>>>><<.<<<<<<<<<<<..>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>.<.<<..<<<..<<<<<<.<..<<<.....<<<<....>>>>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>.>..>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<........>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<......>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<<...<<<<<<<<<<}}}.>>>>>..>>>>>..>>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((..((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))......)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((...........(((((((((((((((((((((((.......(((((((......((((((....)))))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.(((((..(.((((.....)))).)))))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.......(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((..((((((....((.....))..)))))....[[(((.((...((....(((....)))........(.(....(...).....).)....))....))...(((((........)))))]]((((..(((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).))).))).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((..)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...(......((((....))))......).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(..(............)..)....((((.....((((..(((((......)))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.............))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Cryo-EM Structure of the 60S Ribosomal Subunit in Complex with Arx1 and Rei1; 25S RIBOSOMAL RNA 4v8t 7 121 8.1 RF00001 URS000055688D_559292 23142985 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Cryo-EM Structure of the 60S Ribosomal Subunit in Complex with Arx1 and Rei1; 5S RIBOSOMAL RNA 4v8t 8 158 8.1 RF00002 URS00001BF64E_559292 23142985 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Cryo-EM Structure of the 60S Ribosomal Subunit in Complex with Arx1 and Rei1; 5.8S RIBOSOMAL RNA 4v8u AA 1504 3.7 RF00177,RF01959,RF01960 URS000080E226_300852 23527033 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<...........>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<.<<<<...<<.<<<<....>>>>.>>....<<.....>>.....>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((.((...........)).)))).)))))......(((......((((((((..((...(((((((.(((((....((((.(....).)))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..(((((((.((......((........))..........(((((((..(...(..........(...((....))...).........................)).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((.............)))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[))..))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Crystal Structure of 70S Ribosome with Both Cognate tRNAs in the E and P Sites Representing an Authentic Elongation Complex.; 16S RIBOSOMAL RNA 4v8u AV 76 3.7 RF00005 URS00005AA258_300852 23527033 0030533 0006412 300852 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).(((((.......))))).....((.((..]....)).))))))))).... Crystal Structure of 70S Ribosome with Both Cognate tRNAs in the E and P Sites Representing an Authentic Elongation Complex.; MRNA 4v8u AW 77 3.7 RF00005 URS000041AF00_300852 23527033 0030533 0006412 300852 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<...........>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(.(((..]....))).)))))))..... Crystal Structure of 70S Ribosome with Both Cognate tRNAs in the E and P Sites Representing an Authentic Elongation Complex.; RNA 4v8u AX 12 3.7 URS000080E01B_300852 23527033 300852 aaauguucaaaa ............ ............ Crystal Structure of 70S Ribosome with Both Cognate tRNAs in the E and P Sites Representing an Authentic Elongation Complex.; RNA 4v8u BA 2901 3.7 RF02540,RF02541,RF00002 URS000080E0F3_300852 23527033 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgggccgcacgcggcccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu 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.........((((((((((.....(((..((((((((((((......((((((.[[..[[.)))....(((((((...(((]]..]].)))......)))))).).)))....(((....)))((((((((....)))))))).((((((....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((((((.......)))))))....(.(((((((......(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)))..)))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...........................)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((...((.(((......)))..))...))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((((.((.....{....((.(((..(((.........)))..))).....(...((......)).).))......)).))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.((...{{....))))))(((...(((((((((..(.(((.((.....))))).).......)))))))))..)))(....(((....)))......))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((.........))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((...((((.(.........(((((..(((......((((((((....))))))))...)))............)))))).))))...)))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))...................(((((((((.......)))))....((((((((..((....(((.(....).)))...))...))))).)))...))))....... Crystal Structure of 70S Ribosome with Both Cognate tRNAs in the E and P Sites Representing an Authentic Elongation Complex.; 23S RIBOSOMAL RNA 4v8u BB 119 3.7 RF00001 URS00005AB4A7_300852 23527033 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<<....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>> .((((((((((....(((((..(....(((((((...(.....)...))))..)))...)..))).))(((.......((.(((((....))))).)).......))).)))))))))) Crystal Structure of 70S Ribosome with Both Cognate tRNAs in the E and P Sites Representing an Authentic Elongation Complex.; 5S RIBOSOMAL RNA 4v8u CA 1504 3.7 RF00177,RF01959,RF01960 URS000080E226_300852 23527033 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<...........>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<.<<<<...<<.<<<<....>>>>.>>....<<.....>>.....>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((.((...........)).)))).)))))......(((......((((((((..((...(((((((.(((((....((((.(....).)))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..(((((((.((......((........))..........(((((((..(...(..........(...((....))...).........................)).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((.............)))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[))..))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Crystal Structure of 70S Ribosome with Both Cognate tRNAs in the E and P Sites Representing an Authentic Elongation Complex.; 16S RIBOSOMAL RNA 4v8u CV 76 3.7 RF00005 URS00005AA258_300852 23527033 0030533 0006412 300852 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).(((((.......))))).....((.((..]....)).))))))))).... Crystal Structure of 70S Ribosome with Both Cognate tRNAs in the E and P Sites Representing an Authentic Elongation Complex.; MRNA 4v8u CW 77 3.7 RF00005 URS000041AF00_300852 23527033 0030533 0006412 300852 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(.(((..]....))).)))))))..... Crystal Structure of 70S Ribosome with Both Cognate tRNAs in the E and P Sites Representing an Authentic Elongation Complex.; RNA 4v8u CX 12 3.7 URS000080E01B_300852 23527033 300852 aaauguucaaaa ............ ............ Crystal Structure of 70S Ribosome with Both Cognate tRNAs in the E and P Sites Representing an Authentic Elongation Complex.; RNA 4v8u DA 2901 3.7 RF02540,RF02541,RF00002 URS000080E0F3_300852 23527033 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgggccgcacgcggcccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<....>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<.....<<<...<<<<<.<<<<.<<<....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>.>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....<<<<<<<....>>>>>>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<<..>>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<.........>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> .........((((((((((.....(((..((((((((((((......((((((.[[..[[.)))....(((((((...(((]]..]].)))......)))))).).)))....(((....)))((((((((....)))))))).((((((....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((((((.......)))))))....(.(((((((......(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)))..)))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...........................)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((...((.(((......)))..))...))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((((.((.....{....((.(((..(((.........)))..))).....(...((......)).).))......)).))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.((...{{....))))))(((...(((((((((..(.(((.((.....))))).).......)))))))))..)))(....(((....)))......))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((.........))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((...((((.(.........(((((..(((......((((((((....))))))))...)))............)))))).))))...)))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))...................(((((((((.......)))))....((((((((..((....(((.(....).)))...))...))))).)))...))))....... Crystal Structure of 70S Ribosome with Both Cognate tRNAs in the E and P Sites Representing an Authentic Elongation Complex.; 23S RIBOSOMAL RNA 4v8u DB 119 3.7 RF00001 URS00005AB4A7_300852 23527033 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<<....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>> .((((((((((....(((((..(....(((((((...(.....)...))))..)))...)..))).))(((.......((.(((((....))))).)).......))).)))))))))) Crystal Structure of 70S Ribosome with Both Cognate tRNAs in the E and P Sites Representing an Authentic Elongation Complex.; 5S RIBOSOMAL RNA 4v8x AA 1504 3.35 RF00177,RF01959,RF01960 URS000080E260_300852 23945936 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<.........>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<.<<<<....>>>>>>...................>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<...<<<<....>>>>...>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<<..>>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((.........)))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((.(..((((((((((......((........))..........(((((((..(.......(.........(.(....).)........................)....).((.(((....(((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((.(...(..............).....).)))))..(..(((((....))))).....)..)))).....).).)))...)..)))))....)))))))..[)).)))))))).(...(((((((.....(((...(..((((....))))..).....))).....)))))))......(....(((((((........)))))))....)..)..).))).....(.(((((......]...))))).)......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Structure of Thermus thermophilus ribosome; 16S ribosomal RNA 4v8x AV 77 3.35 RF00005 URS000041AF00_300852 23945936 0030533 0006412 300852 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Structure of Thermus thermophilus ribosome; transfer RNA 4v8x AW 77 3.35 RF00005 URS000041AF00_300852 23945936 0030533 0006412 300852 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<...<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>.>>>>>..... .(((.((..(((...........))).(((...........))).....(...(.......)...))).)))..... Structure of Thermus thermophilus ribosome; transfer RNA 4v8x AX 11 3.35 URS000080DD8D_32630 23945936 32630 aaaaugnnnaa ........... ........... Structure of Thermus thermophilus ribosome; 5'-R(*GP*GP*CP*AP*AP*GP*GP*AP*GP*GP*UP*AP*AP*AP *AP*AP*UP*G U2M A2M A2MP*AP*AP*AP*A)-3' 4v8x BA 2848 3.35 RF02540,RF02541,RF00002 URS000080E03F_300852 23945936 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucgggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgggccgcacgcggcccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccagucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<....>>>>>>.>>....<<<<<.....<<....>>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>.....<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<..<<<<<....>>>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<....>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<.......<<<<<<<<....>>>>>>>>....>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<.........>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> .........((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((((((((..).))))))))....((((.(((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))..)))]....((((((((..[......))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...........................)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((.(.((((((......)))).)))..))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......(....)...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.((...{{....))))))(((...(((((((((..(((((.((.....))))))).......)))))))))..)))(....(((....)))......))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((((.......)))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((.(.((((..............((....(......(((..(((....)))..)))...)..............)).....)))).).)))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.((((...........))))...).((]..[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].......(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))...................(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....... Structure of Thermus thermophilus ribosome; 23S ribosomal RNA 4v8x BB 119 3.35 RF00001 URS000080DE2B_300852 23945936 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>> .((((((((((....(((((..(....((((.((...(.....)...)).)..)))...)..))).))(((.......((.(((((....))))).)).......))).)))))))))) Structure of Thermus thermophilus ribosome; 5S ribosomal RNA 4v8x CA 1504 3.35 RF00177,RF01959,RF01960 URS000080E260_300852 23945936 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<.........>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<.<<<<....>>>>>>...................>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<...<<<<....>>>>...>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((.........)))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](.(((.(((((((.((..(((.(..((((((((((......((........))..........(((((((..(.......(.........(.(....).)........................)....).((.(((....(((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((.(...(..............).....).)))))..(..(((((....))))).....)..)))).....).).)))...)..)))))....)))))))..[)).)))))))).(...(((((((.....(((...(..((((....))))..).....))).....)))))))......(....(((((((........)))))))....)..)..).))).....(.(((((......]...))))).)......))...))))))))))..)..(.(..((.(.((((.(((..(((((((((((((...(..(((....((......)).)))..)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Structure of Thermus thermophilus ribosome; 16S ribosomal RNA 4v8x CV 77 3.35 RF00005 URS000041AF00_300852 23945936 0030533 0006412 300852 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Structure of Thermus thermophilus ribosome; transfer RNA 4v8x CW 77 3.35 RF00005 URS000041AF00_300852 23945936 0030533 0006412 300852 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<...<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>.>>>>>..... .((((.(..(((...........))).(((...........))).....(...(.......)...)).))))..... Structure of Thermus thermophilus ribosome; transfer RNA 4v8x CX 10 3.35 URS000080E197_562 23945936 562 aaaaugnnna .......... .......... Structure of Thermus thermophilus ribosome; BACTERIAL TOXIN YOEB 4v8x DA 2848 3.35 RF02540,RF02541,RF00002 URS000080E03F_300852 23945936 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucgggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgggccgcacgcggcccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccagucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<....>>>>>>.>>....<<<<<.....<<....>>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>.....<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<..<<<<<....>>>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<....>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<.......<<<<<<<<....>>>>>>>>....>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<.........>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> .........((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((((((((..).))))))))....((((.(((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))..)))]....((((((((..[......))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...........................)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((.(.((((((......)))).)))..))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......(....)...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.((...{{....))))))(((...(((((((((..(((((.((.....))))))).......)))))))))..)))(....(((....)))......))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((((.......)))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((.(.((((..............((....(......(((..(((....)))..)))...)..............)).....)))).).)))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.((((...........))))...).((]..[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].......(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))...................(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....... Structure of Thermus thermophilus ribosome; 23S ribosomal RNA 4v8x DB 119 3.35 RF00001 URS000080DE2B_300852 23945936 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>> .((((((((((....(((((..(....((((.((...(.....)...)).)..)))...)..))).))(((.......((.(((((....))))).)).......))).)))))))))) Structure of Thermus thermophilus ribosome; 5S ribosomal RNA 4v8y B2 1781 4.3 RF01960,RF01959,RF00177 URS000080DE56_4932 24200810 0003735 0005840 4932 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagannnnnnnnnnnnnnucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucau ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[..................<.....<<.<<<.....>>>.>>......>.........<<<<<..<......>..>>>>>[...((((((......<<<<<<<<<<<....>>>..............)))))).....]...<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<.<<.<<........>>.>>.>>.>>>......<<..<...........>..>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..))))))]]]].........[[[{{.......{{...[[[.[[....<<<<<<.<<<<<....<.>.....>>>>>.>>>>>>....<<<<<<...........<.......>...........>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[...((((((((....>>>>>>>>.))))))))..]].....]]....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<<<......>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>>....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<......<<<<<<<.<<..................>>.>>>>>>>......>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>....... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[[[[[[[(((....))).....(......).)))))).)...).(.((((..((.......)).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....((..(.(((............))).)...))......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((((.....().....))))).))))))....((((((...............................))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(......((.(((....]]]]]]]].))).)).....).....))...(((..((..(...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)..))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...((.((((.(....................).)))).))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>...... Cryo-EM reconstruction of the 80S-eIF5B-Met-itRNAMet Eukaryotic Translation Initiation Complex; 18S RIBOSOMAL RNA 4v8y B5 3147 4.3 RF02540,RF02543 URS000061F377_4932 24200810 0003735 0005840 4932 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacauggcugggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuaagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu 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Cryo-EM reconstruction of the 80S-eIF5B-Met-itRNAMet Eukaryotic Translation Initiation Complex; 25S RIBOSOMAL RNA 4v8y B7 121 4.3 RF00001 URS000055688D_4932 24200810 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Cryo-EM reconstruction of the 80S-eIF5B-Met-itRNAMet Eukaryotic Translation Initiation Complex; 5S RIBOSOMAL RNA 4v8y B8 158 4.3 RF00002 URS00001BF64E_4932 24200810 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Cryo-EM reconstruction of the 80S-eIF5B-Met-itRNAMet Eukaryotic Translation Initiation Complex; 5.8S RIBOSOMAL RNA 4v8y CN 87 4.3 RF02541 URS000080DF88_4932 24200810 0003735 0005840 4932 gucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcgg .<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>> .((.((((..{.....[..(((.(..(((......(.((.(.(...}).).)).)...)))..........].).)))..)))).)) Cryo-EM reconstruction of the 80S-eIF5B-Met-itRNAMet Eukaryotic Translation Initiation Complex; EUKARYOTIC RIBOSOMAL L1_RRNA 4v8y CW 74 4.3 RF00005 URS00005AA258_4932 24200810 0030533 0006412 4932 gcccggauagcucaggguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<......>>>><<<<<<<.....>>>>>>.>...<<<<<.......>>>>>>>>>>>>.... (((((((..((.(...[..).))..((((.......))))......(((((..]....)))))))))))).... Cryo-EM reconstruction of the 80S-eIF5B-Met-itRNAMet Eukaryotic Translation Initiation Complex; EUKARYOTIC RIBOSOMAL P_E TRNA 4v8z B2 1781 6.6 RF01960,RF01959,RF00177 URS000080DE56_4932 24200810 0003735 0005840 4932 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagannnnnnnnnnnnnnucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucau 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Cryo-EM reconstruction of the 80S-eIF5B-Met-itRNAMet Eukaryotic Translation Initiation Complex; 18S RIBOSOMAL RNA 4v8z B5 3147 6.6 RF02540,RF02543 URS000061F377_4932 24200810 0003735 0005840 4932 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........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<.<<<<<..<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>......>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<<...........<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<<..<<<<<<.....>>>>>>>>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<..........<<<...<<.........>>...>>>.........<<......>>...........>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<<.....>.>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>.>>>>>..<<<<.....<<<<<<<.<<...............<<<<<...............>>>>><<.<<<<<<<<<<<..>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>.<.<<..<<<..<<<<<<.<..<<<.....<<<<....>>>>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>.>..>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<........>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<......>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<<...<<<<<<<<<<}}}.>>>>>..>>>>>..>>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((..((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))......)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((...........(((((((((((((((((((((((.......(((((((......((((((....)))))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.(((((..(.((((.....)))).)))))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((..........(((...((.........))...))).....(...((......)).).........)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((..((((((....((.....))..)))))....[[(((.((...((....(((....)))........(.(....(...).....).)....))....))...(((((........)))))]]((((..(((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).))).))).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((..)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...(......((((....))))......).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(..(............)..)....((((.....((((..(((((......)))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.............))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Cryo-EM reconstruction of the 80S-eIF5B-Met-itRNAMet Eukaryotic Translation Initiation Complex; 25S RIBOSOMAL RNA 4v8z B7 121 6.6 RF00001 URS000055688D_4932 24200810 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Cryo-EM reconstruction of the 80S-eIF5B-Met-itRNAMet Eukaryotic Translation Initiation Complex; 5S RIBOSOMAL RNA 4v8z B8 158 6.6 RF00002 URS00001BF64E_4932 24200810 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Cryo-EM reconstruction of the 80S-eIF5B-Met-itRNAMet Eukaryotic Translation Initiation Complex; 5.8S RIBOSOMAL RNA 4v8z CW 76 6.6 RF00005 URS000080E129_4932 24200810 0030533 0006412 4932 gcccggauagcucagucgguagagcaggggauucauaauccccguguccuugguucgauuccgaguccgggcacca ....<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>........ ..(.(((..((((........)))).(((((.......))))).....(((((.......)))))))).)...... Cryo-EM reconstruction of the 80S-eIF5B-Met-itRNAMet Eukaryotic Translation Initiation Complex; EUKARYOTIC RIBOSOMAL PI TRNA 4v90 AA 1507 2.95 RF00177,RF01959,RF01960 URS00006D750F_300852 23912278 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggauca ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<.......>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<...<<<<<<....>>>>>>.....<<......>>...>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>...... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((.................)))).)))))......(((......((((((((..((...(((((((.(((((....((((........)))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((........((((((....))))))......(..(..).)........)))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.((((((...((..............).)....)))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Thermus thermophilus Ribosome; 16S RIBOSOMAL RNA 4v90 AV 76 2.95 RF00005 URS000080DEEA_300852 23912278 0030533 0006412 300852 gcccggauagcucagccgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((.(.....[..).))..((((.......))))......(((((..]....)))))))))))).... Thermus thermophilus Ribosome; RNA (77-MER) 4v90 BA 2901 2.95 RF02540,RF02541,RF00002 URS000080E31E_300852 23912278 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgggccgcacgcggcccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgcggcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccuguaaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu .........<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<....>>>>>>.>>....<<<<<.....<......>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.......<<<<<....>>>>>......>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<........>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<.<........<<<<<.<<<..<<<.........>>>..>>>.........<<......>>...>>>>>....>.>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<<..>>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...................<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....... (........((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...........................)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((...((...............))...))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((((.((........((((.(((...................))).........((......))...))))....)).))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.(.((.((...{{....)))).)(((...((((((((((.(((((.((.....))))))).).....)))))))))..)))(....(((....)))......))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((((.((((.([.....{..(((((..(((......(.(.((((...]))).)).)...)))..........}.)))))).)))).)))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))...(.........).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))......) Thermus thermophilus Ribosome; 23S RIBOSOMAL RNA 4v90 BB 119 2.95 RF00001 URS00005AB4A7_300852 23912278 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>> .((((((((((....(((((.((....((((((....(.....)....)))..)))...)).))).))(((.......((.(((((....))))).)).......))).)))))))))) Thermus thermophilus Ribosome; 5S RIBOSOMAL RNA 4v91 1 3203 3.7 RF02540,RF02543 URS000080DF9A_28985 24792965 0003735 0005840 28985 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacagccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacaagggaugcguaggauaggugggagcgcaagcgccggugaaauaccacccuucccauguuucuuuaccuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu .........................<<<<<.....<......>......>>>>>.....<.....<<....>>..<<<<<......<<.....>>.....>>>>>..<<<..<........<<.<<<<<<...>>>>>>.>>........>....<<<<<<.<<<<<<<<<<<<<<<<<<<<<.....<<<<......>>>>.(.......<<<......)>>>....>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>....>.............................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<.....<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<..<.<<<<<..<<<<<<.....>>>>>>>>>>>.>..>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>..>.....>>>>>><<<....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.....{{<<<<<<...<<<<.<<<<<<<<<<<<<<<<<<..[[[..>>>>>>....<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>.....<<<<<<<<....>>>>>>>>>>>>.>.>>>>>>>.>>>>.........>>>>>>..........>>.>.>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<.<<<<<<<<<<......>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.....<<.....<<<<....>>>>.....>>..>>>>..>>>>>.<<<<<.......>>>>>.........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>...>>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<....<<<<<<<<..<<<<...........<<<<<..<......>............>>>>>..>>>>..>>>>>>>>......<<<<<.....<<<<..<<<<<......>>>>>..........}}...<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))......<<<<<<<..<<<<.))))))>>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<....<<<<<<<<<<]]].>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<...<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>...>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<.<.....>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((.(((...))).)).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((....(((((((((((((((((((((((.......(((((((......((((.(....).)))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..((((......))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((........)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...((((((.....)))))).)))).)..)))..)).).....)))))...((((..(((.(......))))..)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((.(((...((.........))...))).....(...(........).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))((((((((((.((......((((.((((....))))))))...)))))))))).)).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....))).........(...(........)....)....))....))...(((((........)))))]]((((..(((.(((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....)))...))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((((.(...)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.....((.....((((....)))).....))..))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..((.((((......(((........[..(((((..((....))..........].)))))..))).....).))).).)....((((.....((((..(((..........)))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))....))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......(((.((.(((.((....((.(........((((((.....)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).)).)))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(.(.((..)..).).)..)))))...)))....)))).)))))).))))).. Kluyveromyces lactis 80S ribosome in complex with CrPV-IRES; 25S RRNA 4v91 3 121 3.7 RF00001 URS000055688D_28985 24792965 0003735 0005840 28985 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<.....<<<<<<<<....<<<.<<..............>>....>>...>>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>.>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Kluyveromyces lactis 80S ribosome in complex with CrPV-IRES; 5S RRNA 4v91 4 158 3.7 RF00002 URS00001BF64E_28985 24792965 0003735 0005840 28985 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<<<<....>>>>.....<.<<<......>>..............>>>..>...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(..(((.....]]............).))...)...)))....((.....))(((((((((....)))))))))..................... Kluyveromyces lactis 80S ribosome in complex with CrPV-IRES; 5.8S RRNA 4v92 A2 1764 3.7 RF01960,RF01959,RF00177 URS000080DD84_28985 24792965 0003735 0005840 28985 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauagacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaauuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuuggaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucau ...<<<<<.{.((((>>>>><<<<.<<<<<<...<.<..........<<..<<<..<<....<<....<<..........>>...>>.>>......<<........<<<..<<..<<....<<<..................<.....<<.<<<.....>>>.>>......>.........<<<<<..<<....>>..>>>>>....<<<<<<......((((.{..<<.<..>.>>..............>>>>>>.........<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<......>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>.>>.........<<<....<<<.....>>>..>>>.......>.>.....<..<<<<<<..<<....>>..>>>>>>....>.....<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>>.........<<<[[.....<.<<...<<<.<<....<<<<<<.<<<<<....<..>....>>>>>.>>>>>>.....<<<<<....<......<.......>......>....>>>>>....<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>........<<...<<<<<<<.......}.))))..>>>>>>>..>>.....>>....<<<<<<.<<...<<<<..<<<.<<<<<<.<...<<<......>>>......>.>>>>>>.>>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<..<<........>>.>>>>>>>>..>>>...<<..]]>>...>>.....>>>.>>>.<<<......<<<......>>>....>>>..)))).}...<<.<<<<<<<..<<.<<<<<....<<.<<<<<<......<<........>>..........<<<<<......<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<.<<<....<<<.<<.<......>....<<<......>>>...>>.>>>....<<<<..<<..<<<<..<<<<<.<..<<<....>>>..>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>....>>>..>>.....>>>>>>>.......>>>>>...>>.>>>>.>>......<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>......>>>>>>>...........<<<<<<..........>>>>>>...........>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>...........<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<....<<.<<<.<<....>>.>>>.>>....>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>..........<<<<<<<<....>>>>>>>>........ ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...))[))......(((.......(.(..((..((....(((..................((....((.(((.....))).)).....)).........(((((..(......)..)))))(.(.((((((......{...{{..(((....))).....(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..).).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)....).).....((..(((((............)))))...))......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..[......((([[...(.(.(.....((.((.....(((((..(((......()......)))..))))).....((((.(...............................).))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).......((....(.((.(((......}}...}.))).)).)...)..)..))...(((..((..(...((((..((..(((((......(..........).........)))))..)).......((....))...))))..)..))...))..))).....).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..((((((((.(((........)))))))))))..)))...((..]]))...))...].))))))).(((......((((....))))....)))...]]].]...((.(((((((..(...(((.(...((..(((((......((........))...........((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.((.((....))...(.((......)))...)).)))....(((((.((..(((....((((..(.(((....))).)....))))....))).))....(((((.......)))))......)))))....))).))).....).))))).....).))).)...)).)))..))..(...(((((.(......((.....((..((((....))))..))....))......).)))))......(....((((((..........))))))....)..)..).))).....(.((((((.......)))))).).......)...)))))))))......(.(..((.(..((((.((..(.(.((((((.(((....((..(.....((((..((....))..)))).....)..))....))).)))))).))..)).))))...).))...)..)..(((((((((....)))))))))}...... Kluyveromyces lactis 80S ribosome in complex with CrPV-IRES; 18S RRNA 4v92 AZ 190 3.7 RF00458 URS000080DD48_12136 24792965 0043022 12136 aaaaaugugaucuugcuuguaaauacaauuuugagagguuaauaaauuacaaguagugcuauuuuuguauuuagguuagcuauuuagcuuuacguuccaggaugccuaguggcagccccacaauauccaggaagcccucucugcggucgaaaaaccuagguagguuuuucuaagaaauuuaccuauuuuu <<<<<.........<.<<<<<<...........[.[..........>>>>>>.>.......>>>>>......<<<<.<<<<....>>>>.....((((..((.>>>>.<<<.......>>>....))..))))....].]........<<<<<<<<.(((((>>>>>>>>.........)))))...... ((((..........(((((((...........[[[[...........)))))))........)))).....(((((.((((....))))......[[[...[.)))))(((.......)))....]...]]].....]]]]........[[[[[[..((((((]]]]]].........))))))...... Kluyveromyces lactis 80S ribosome in complex with CrPV-IRES; RNA OF CRICKET-PARALYSIS-VIRUS-IRES 4v95 AA 1466 3.2 RF00177,RF01959,RF01960 URS000080E226_300852 22422986 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcccgggugaaagccugggcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggau .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<..>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<...<<<<<<......>>>>>.>...>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<<....>>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((((((()))))))).)))))......(((......((((((((..((...(((((((.(((((.....(((........)))......)))))....((((..((((....))))..))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[....((((.....((.]]])).......)))).)))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((((....)))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..((...(((.....)))).)...))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}... Crystal structure of YAEJ bound to the 70S ribosome; 16S Ribosomal RNA 4v95 AV 77 3.2 RF00005 URS000041AF00_300852 22422986 0030533 0006412 300852 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of YAEJ bound to the 70S ribosome; P-site fMet-tRNA 4v95 BA 2752 3.2 RF02540,RF02541,RF00002 URS00001698E8_300852 22422986 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgggccgcggcccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagcggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgagucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<...>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<<<<<<..>>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<...>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<..>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>...>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((.(((((..).)))).)))....(.(((((((((..(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((...))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....(((((((())))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((.(.((((((......)))).)))..))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((...............)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((((((())))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))...(((.))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...))) Crystal structure of YAEJ bound to the 70S ribosome; 23S Ribosomal RNA 4v95 BB 120 3.2 RF00001 URS00005F2F4B_300852 22422986 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> (((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).))))))))))) Crystal structure of YAEJ bound to the 70S ribosome; 5S Ribosomal RNA 4v95 CA 1461 3.2 RF00177,RF01959,RF01960 URS000080E226_300852 22422986 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcccgggugaaagccugggcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<..>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<<....>>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((((()))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((((....)))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..((...(((.....)))).)...))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Crystal structure of YAEJ bound to the 70S ribosome; 16S Ribosomal RNA 4v95 CV 77 3.2 RF00005 URS000041AF00_300852 22422986 0030533 0006412 300852 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of YAEJ bound to the 70S ribosome; P-site fMet-tRNA 4v95 DA 2722 3.2 RF02540,RF02541,RF00002 URS00001698E8_300852 22422986 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucgcgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgagucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<.<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>..>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<...>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<..>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<..>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>...>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...(((((((((..).))))))))....{.(((((((((.(...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)..)))))).))))....(((((((((.[.....)))))))))....}..((((].[[[[))))...)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((...))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((()))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((.(.((((((......)))).)))..))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...(((..(((...((([[[...(.((((((.....(.....((..(((((((((()))))))))).))..........]]].)....))))))))))...))).)))(((((((())))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((.(((((((.((.....)))))))))......))))))))..)))(...(.((..)).).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((.(((()))).)))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.((((...........))))...).((]..[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].......(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))...(((.))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...))) Crystal structure of YAEJ bound to the 70S ribosome; 23S Ribosomal RNA 4v95 DB 120 3.2 RF00001 URS00005F2F4B_300852 22422986 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>. .((((((((((....((((((.(....(((((((...(.....)...))))..)))...).)))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of YAEJ bound to the 70S ribosome; 5S Ribosomal RNA 4v97 AA 1504 3.516 RF00177,RF01959,RF01960 URS000080E306_300852 23630274 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugaaaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<<<<<<...........>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<.<<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<.<<..<<<<<<<....>>>>>>>....<.......>....>>.>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<....<<.....>>.>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<...<<<<....>>>>...>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((..(...........)..)))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((.(((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..)))))..))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((.(..((((((((((......((........))..........(((((((..(...((.((.(...(((.(((....))).)))...................))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...(..............).....))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....((.......((((....)))).........)).....)))))))......(....(((((((........)))))))....)..)..).))).....(((((((..........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Crystal structure of the bacterial ribosome ram mutation G299A.; 16S rRNA 4v97 AV 77 3.516 RF00005 URS000041AF00_83333 23630274 0030533 0006412 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the bacterial ribosome ram mutation G299A.; P-SITE tRNA fMet 4v97 AW 76 3.516 RF00005 URS00005AA258_83333 23630274 0030533 0006412 83333 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... ((((.((..((((........)))).((((.........)))).....(((((.......))))))).)))).... Crystal structure of the bacterial ribosome ram mutation G299A.; E-SITE TRNA PHE OR A-SITE tRNA Phe 4v97 AX 12 3.516 23630274 uaaaaauguuca ............ ............ Crystal structure of the bacterial ribosome ram mutation G299A.; mRNA 4v97 AY 17 3.516 RF00005 URS00005AA258_83333 23630274 0030533 0006412 83333 ggggauugaaaaucccc <<<<<<.....>>>>>> .((((.......)))). Crystal structure of the bacterial ribosome ram mutation G299A.; E-SITE TRNA PHE OR A-SITE tRNA Phe 4v97 BA 2810 3.516 RF02540,RF02541,RF00002 URS00001698E8_300852 23630274 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucgcgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>....<<<<<.....<......>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<..<...<<<<..<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>...>>>>..>...>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<....<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.....>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<................>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>>....<<<..>>>......>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<<..<<.......>>>..>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<.......>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> .(.......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((..))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...((((((((.....))))))))....{.(((((((((.(...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)..)))))).))))....(((((((((.[.....)))))))))....}.(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....)))))))))))...(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((.....((((......))))......)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((((....................))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....((((..(((..(((((.((((.((...{{....))))))(((...((((((.(((.(((((.((.....))))))).).....)).))))))..)))(...(((()))).....))))))...)))...))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((((.......)))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).[..(((((......].)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((((.((((.(......[..(((((..(((......((((((((....))))))))...)))..........].)))))).)))).)))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))...(.........).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...)))).....). Crystal structure of the bacterial ribosome ram mutation G299A.; 23S rRNA 4v97 BB 119 3.516 RF00001 URS00005F2F4B_300852 23630274 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>> .((((((((((....((((((.(....(((((((...(.....)...))))..)))...).)))).))(((.......((((((((....)))))))).......))).)))))))))) Crystal structure of the bacterial ribosome ram mutation G299A.; 5S rRNA 4v97 CA 1504 3.516 RF00177,RF01959,RF01960 URS000080E306_300852 23630274 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugaaaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<...........>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>........<.<<<<<<<......<<<<<.<<..<<<<<<<....>>>>>>>....<<.....>>....>>.>>>>>.<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<....<<.....>>.>.....>>>>>>>.....<<<<<....>>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>>..>>.>>>>>>>>.....<<<<<<<.....<<<..<...<<<<....>>>>...>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((.................)))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((.(...(((((((....)))))))...................))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...(..............).....)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((...(..((((....))))..).....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Crystal structure of the bacterial ribosome ram mutation G299A.; 16S rRNA 4v97 CV 77 3.516 RF00005 URS000041AF00_83333 23630274 0030533 0006412 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(((((.......)))))))))))..... Crystal structure of the bacterial ribosome ram mutation G299A.; P-SITE tRNA fMet 4v97 CW 76 3.516 RF00005 URS00005AA258_83333 23630274 0030533 0006412 83333 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<.<<..<<<..........>>>.<<<<<.......>>>>>.....<<<...........>>>>>.>>>>.... (((...(..(((..........))).((((.........)))).....(((...........))))...))).... Crystal structure of the bacterial ribosome ram mutation G299A.; E-SITE TRNA PHE OR A-SITE tRNA Phe 4v97 CX 10 3.516 23630274 aaaauguuca .......... .......... Crystal structure of the bacterial ribosome ram mutation G299A.; mRNA 4v97 CY 17 3.516 RF00005 URS00005AA258_83333 23630274 0030533 0006412 83333 ggggauugaaaaucccc <<<<<<.....>>>>>> .((((.......)))). Crystal structure of the bacterial ribosome ram mutation G299A.; E-SITE TRNA PHE OR A-SITE tRNA Phe 4v97 DA 2824 3.516 RF02540,RF02541,RF00002 URS00001698E8_300852 23630274 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucgcgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccagauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>....<<<<<.....<<....>>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<..<...<<<<..<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>...>>>>..>...>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<........>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[....>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<..]]].>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<.......>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> .(.......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...((((((((.....))))))))....[.(((.((((..(...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)...))))..))))....(((((((((.{.....)))))))))....].(((((}.[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).......(((((((((((....)))))))))))...(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((...((((((......)))).))...))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......(((((........)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.((...{{....))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(....((()))......))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((((.......)))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)..[..(((((......].)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((((.((((.(......[..(((((..(((.......(((((((....)))))))....)))..........].)))))).)))).)))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))...(.........).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...)))).....). Crystal structure of the bacterial ribosome ram mutation G299A.; 23S rRNA 4v97 DB 119 3.516 RF00001 URS00005F2F4B_300852 23630274 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>> ..(((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((....)))))))).......))..))))))))). Crystal structure of the bacterial ribosome ram mutation G299A.; 5S rRNA 4v9a AA 1506 3.2999 RF00177,RF01959,RF01960 URS000080DEDF_300852 23431179 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggauc ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<..<<<<<...<.....>...>>>>>..>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<..[.>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>.......]..<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>....<.......>....>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>..... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(.(((.(...........).))).).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((((..(((((((....)))))))...((........))..))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((.....(...(((.....))).)......))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Crystal Structure of the 70S ribosome with tetracycline.; 16S ribosomal RNA 4v9a AC 77 3.2999 RF00005 URS000057545F_300852 23431179 0030533 0006412 300852 cgcgggguggagcagcccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal Structure of the 70S ribosome with tetracycline.; TRNA-FMET 4v9a BA 2912 3.2999 RF02540,RF02541,RF00002 URS000080E23D_300852 23431179 0003735 0005840 300852 ggucaagaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaacggcccgcacgcgggccgaaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggauguuggcuuagaagcagccaucauuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucuugacc .<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.....>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....<<<<<<......>>>>>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<........>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<..<...<<<.........>>>...>..........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<..<<<<<<<...........<...<..<<........<<<<<<......>>>>.>>....>>.............>..>..>>>>>>>..>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<..<<<<<<<<..<<.......>>>..>>>>>>>...>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>>. ((..((((......((((((((((.....(((..((((((((((((......((((((.[[..[[[)))...].((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....(((((.......).))))....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((...((.(((......)))..))...)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......(((((.(.(..(((.........)))..).).....(....(......)..).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((.(((((((..(.........(..(...((.........((((........))).).....))............)...))..))))))).)))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.(((.......)))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))))..)) Crystal Structure of the 70S ribosome with tetracycline.; 23S ribosomal RNA 4v9a BB 122 3.2999 RF00001 URS00005AB4A7_300852 23431179 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga ..<<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> ..(((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).))))))))))) Crystal Structure of the 70S ribosome with tetracycline.; 5S RIBOSOMAL RNA 4v9a CA 1506 3.2999 RF00177,RF01959,RF01960 URS000080DEDF_300852 23431179 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggauc ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<.......>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<.......<<<<<<....<<<<<<....>>>>>>.....<<......>>....>>>>>>..<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<...<<<.....>>>.>.....>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((((((((.(...).))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((.(((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..)))))..))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(....(((((((..(((((((....)))))))....(((....)))...))))))).).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((.......(((.....)))......))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...((((((......(((..(((.(((......)))).))....)))......))))))......(....(.(((((........))))).)....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Crystal Structure of the 70S ribosome with tetracycline.; 16S ribosomal RNA 4v9a CC 77 3.2999 RF00005 URS000057545F_300852 23431179 0030533 0006412 300852 cgcgggguggagcagcccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal Structure of the 70S ribosome with tetracycline.; TRNA-FMET 4v9a DA 2909 3.2999 RF02540,RF02541,RF00002 URS000080E23D_300852 23431179 0003735 0005840 300852 ggucaagaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaacggcccgcacgcgggccgaaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggauguuggcuuagaagcagccaucauuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucuugacc ...<<<<<......<<<<<<<<<<<.....<<.<<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<..>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>>..............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....<<<<..........>>>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<.<<<......>>>..>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<...................................<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<.<<<<<.............<<<<...........<<<<<<<<....>>>>>>>>..................>>>.>...>>>>>.>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<..<<<<<<<...<<.......>>...>>>>>>>...>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>... ...(((((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((..)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....((((.(......).))))....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...).)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((...((.(((......)))..))...)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[.....((((((.....(.....((..((((((((((.....{.(((((.(.....(.(.......).).....).........((......))...)))))...)))))))))).))..........]]].)....)))))).)))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...(((((((((((((((..((.....)).)))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.[..).....)))))((((((((((((.....))))))))))))(...).......(((((((((...((.........))...(((((((.....(((....))).......))))))).]((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((.(.(((..((((..(...........((.....(.......(((.(((....))).)).)....).............).)..)..))))..)).)).)))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...))))).<.)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..(((.......)))....(((((((((.......)))))....((((((((..((....(((((....)))))...))..>))))).)))...))))....)))))... Crystal Structure of the 70S ribosome with tetracycline.; 23S ribosomal RNA 4v9a DB 122 3.2999 RF00001 URS00005AB4A7_300852 23431179 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga ...<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>. ...((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).)))))))))). Crystal Structure of the 70S ribosome with tetracycline.; 5S RIBOSOMAL RNA 4v9b AA 1506 3.1 RF00177,RF01959,RF01960 URS000080DEDF_300852 23431179 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggauc ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<.............>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<......>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<...<<<<....>>>>...>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(.((((.............)))).).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((((..(((((((....)))))))...((((....))))..))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((.(...(...(((.....))).)....).)))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Crystal Structure of the 70S ribosome with tigecycline.; 16S ribosomal RNA 4v9b AC 77 3.1 RF00005 URS000057545F_300852 23431179 0030533 0006412 300852 cgcgggguggagcagcccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(((((.......)))))))))))..... Crystal Structure of the 70S ribosome with tigecycline.; TRNA-FMET 4v9b AD 77 3.1 RF00005 URS000057545F_300852 23431179 0030533 0006412 300852 cgcgggguggagcagcccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>......<<<.........>>>.>>>>>>..... .((((((..((((......[..)))).(((((.......))))).......((...].....))..))))))..... Crystal Structure of the 70S ribosome with tigecycline.; TRNA-FMET 4v9b BA 2912 3.1 RF02540,RF02541,RF00002 URS000080E23D_300852 23431179 0003735 0005840 300852 ggucaagaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaacggcccgcacgcgggccgaaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggauguuggcuuagaagcagccaucauuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucuugacc .<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.....>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....<<<<<........>>>>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<.........>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<<..<<.......>>>..>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>>. (...((((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((.(((((..).)))).)))....(.(((((((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....(((.(.......)..)))....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((...((.(((......)))..))...)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......(((((..((...(...........)...))......(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))(((((((.......)))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((.(.....))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((.(((((.((((((.(.........(((((..(((......((((((((....))))))))...)))............)))))).)))))).))))).)))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....((((((..((..]]]]..)).)))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.(((.......)))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))))...) Crystal Structure of the 70S ribosome with tigecycline.; 23S ribosomal RNA 4v9b BB 122 3.1 RF00001 URS00005AB4A7_300852 23431179 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga ..<<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> ..(((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).))))))))))) Crystal Structure of the 70S ribosome with tigecycline.; 5S RIBOSOMAL RNA 4v9b CA 1506 3.1 RF00177,RF01959,RF01960 URS000080DEDF_300852 23431179 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggauc ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<.......>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<...<<<<<<....>>>>>>..<.<<<......>>>.>>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<...<<<.....>>>.>.....>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((((((((((...))))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((.(....).)))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((.(((((...))))).))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((......(((..(((..(((((((....)))))))...((((....))))..)))..)))..((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.((((.((.......(((.....)))......)).))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((..........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Crystal Structure of the 70S ribosome with tigecycline.; 16S ribosomal RNA 4v9b CC 77 3.1 RF00005 URS000057545F_300852 23431179 0030533 0006412 300852 cgcgggguggagcagcccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal Structure of the 70S ribosome with tigecycline.; TRNA-FMET 4v9b CD 77 3.1 RF00005 URS000057545F_300852 23431179 0030533 0006412 300852 cgcgggguggagcagcccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca ..<<<<...<<<...........>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>.>>>>...... .....((..(((...........))).(((((.......))))).....((.((.......)).))))......... Crystal Structure of the 70S ribosome with tigecycline.; TRNA-FMET 4v9b DA 2906 3.1 RF02540,RF02541,RF00002 URS000080E23D_300852 23431179 0003735 0005840 300852 ggucaagaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcggcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaacggcccgcacgcgggccgaaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggauguuggcuuagaagcagccaucauuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucuugacc .<<<<<<<......<<<<<<<<<<<.....[[.(((<<<<<<[[<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<.>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...(((....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>.)))..............<<....>>....]].........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....<<<<<........>>>>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<.<<........>>..>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<......<.<.<<<........<.........>................<........>...>>>.>.>..>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..((((...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.........<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<.<..<<<......<<<<<<<<....>>>>>>>>...>>>.............>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<.(((..>>>>..)))>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))))>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>>. ..((.(.(......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((.))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...(((((((((..).))))))))....{.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).))))....(((((((((.[.....)))))))))....}.(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....((..............))....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...((((((.((...(((...(((.((((.....((.(......).))......)))).)))..)).)...)).))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[.....((((((.....(.....((..((((((((((.....{..(.((...(...(.(.......).)...)...........((......))...))).....)))))))))).))..........]]].)....)))))).)))...)))))))(((((((.......)))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((.((((((((((((.(.........(((.(..((.......((((((((....))))))))....)).............))))).)))))))))))).)))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...))))).<.)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((.......)))....(((((((((.......)))))....((((((((..((....(((((....)))))...))..>))))).)))...))))...)).).)).. Crystal Structure of the 70S ribosome with tigecycline.; 23S ribosomal RNA 4v9b DB 122 3.1 RF00001 URS00005AB4A7_300852 23431179 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga ..<<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> ...((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).)))))))))). Crystal Structure of the 70S ribosome with tigecycline.; 5S RIBOSOMAL RNA 4v9c AA 1539 3.3 RF00177,RF01959,RF01960 URS00000ABFE9_83333 22902368 0003735 0005840 83333 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<...<<<<<<<<<<....>>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<.<......<<<<....>>>>.....>.>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>..>>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<.......<<<....>>>.....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<.<......<<........>>..........<<<<<<<......<<<<<<<..<..<<<<....>>>>..>.............>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<<..<<<.....>>>>>.....>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>..>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((..((((..(((((((((....(((.(((..(((..((.((..(..(((((........)))))...)))..)))))......(((......(((((((..((...(((((((.(.((......(((........))).......)).).....((......))....((((....((....))..)))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((.(.........)))))).((((....))))...)))))).).......(((...(((((....)))).))))..)).))))))..((.(......((((....)))).....).))...(.(((((...(...(((((((((.......)))))))).)...)....)))))....)..((((([[[...(((.(.....((.]]])).......).))))))))..)))).))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((.((((((((.....)))))))).)))...((..]])).....)))))))))).(((.......(((....))).....)))...]]].](((((.(((((((.((..(((.(..(((((.((((......((........))..........(((((((..(...(..(..(......((......))........(....)...)..)...)).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((.(.......(((.....)))......).)))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)).))))).(...((((((......(((..((...((......))...))....)))......))))))......(....(((((((........)))))))....)..)..).))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((.(((....((.((..((.(..((....)).).)).)).))...))).))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Allosteric control of the ribosome by small-molecule antibiotics; 16S ribosomal RNA 4v9c AV 76 3.3 RF00005 URS00005AA258_83333 22902368 0030533 0006412 83333 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).(((((.......))))).....((.((..]....)).))))))))).... Allosteric control of the ribosome by small-molecule antibiotics; Phenylalanine specific transfer RNA, tRNA-Phe 4v9c AX 16 3.3 22902368 268588 aaggagguaaaauucu ................ ................ Allosteric control of the ribosome by small-molecule antibiotics; Messenger RNA, mRNA 4v9c BA 2897 3.3 RF02540,RF02541 URS00004B0F34_83333 22902368 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu 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((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))((((((......)))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....)).........((((.....)))).............).....)))))))))).....(.((((..(((.(......).)))..)))).[.(.(........).).((((((....(((((((((((((..(((....(.....)....)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((..........))...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.......(.(((.((.....(.........).....))........(((......)))..))).)...)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(.......(.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((..(((.(.(((....((....))....)))..))))..(((((........)))))]](((((((...(((...(.((....((((..(((..(((((((((.((....{{.).).))))((..((((.....((.(.(((((.((.....))))))).)...))....[))))...))(...(((......)))....))))))...)))...))))(..).....)).)...))....)...)))))))..)).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(.......]...)...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((.............)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))......)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((.(.(((...((............((......((......((((((.(....).))))))...))................))...))...))).).))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((]..[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].......(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}..))))))..)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.((((.(..)..))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Allosteric control of the ribosome by small-molecule antibiotics; 23S ribosomal RNA 4v9c BB 118 3.3 RF00001 URS0000049E57_83333 22902368 0003735 0005840 83333 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))). Allosteric control of the ribosome by small-molecule antibiotics; 5S ribosomal RNA 4v9c CA 1538 3.3 RF00177,RF01959,RF01960 URS00000ABFE9_83333 22902368 0003735 0005840 83333 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccucc .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<...<<<<<.<<<<....>>>.>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>.>..........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<.......<<<<<<..<<<<<<<....>>>>>>>.............>>>>>.>..<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<....<<<....>>>....>....>>>.....>>>>>>>......<.....<<<<<<........>>>>>>.....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<...<<....>>..>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>........... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((.(..(((....)))..)..)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((.(....).))))......)).).....((......))....(((.((...(.....))).))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((..((..(((.((.(((.......))).)).).))..)..).)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(.((((..(((((((((.......((((((.....)))))).....)))))))..)).)))).)...((((((((...((((((.(....(((((((...((........))......)))))))....).......((....))..))))))..))).)))))...)))...))))....((.(((...((...((((.........))))...))))).))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(.(((..((((((((((......((........))..........(((((((..(...(((..((..(.((..........)).)...((....))..))..).))).((.(((...((((((.(....((((((.((....))....(((......)))...)))))).....(.((.((((.((...((..((.......))))....)).))))..(..((..(.....)..)).....)..)).).....).).)))...)).)))))....)))))))...)).)))))))).....((..((......(((..((...((......))...))....)))......))..)).............((.((........)).))............))).).....(((.(((.........))).)))......))...)))))))))).))..(.(..((...((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))....))...)..)..(((((((((....)))))))))}.......... Allosteric control of the ribosome by small-molecule antibiotics; 16S ribosomal RNA 4v9c CV 76 3.3 RF00005 URS00005AA258_83333 22902368 0030533 0006412 83333 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca ..<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>.>>..... ...(((....(((.....[..)))(.(((((.......))))))....(......]........).)).)...... Allosteric control of the ribosome by small-molecule antibiotics; Phenylalanine specific transfer RNA, tRNA-Phe 4v9c CX 15 3.3 22902368 268588 aggagguaaaauucu ............... ............... Allosteric control of the ribosome by small-molecule antibiotics; Messenger RNA, mRNA 4v9c DA 2897 3.3 RF02540,RF02541 URS00004B0F34_83333 22902368 0003735 0005840 83333 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Allosteric control of the ribosome by small-molecule antibiotics; 23S ribosomal RNA 4v9c DB 119 3.3 RF00001 URS0000049E57_83333 22902368 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>> .(((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))). Allosteric control of the ribosome by small-molecule antibiotics; 5S ribosomal RNA 4v9d AA 1538 3.0 RF00177,RF01959,RF01960 URS000080DDC0_562 21596992 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccucc .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<...<<<<<.<<........>>.>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<<..>>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<.<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>.............>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>..>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>........... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((.(....).))))).)))))..)))))......(((......(((((((..((...(((((((...((.....((((((....))))))......)).......(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(..(.((((((((.......)))))))).)...)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((.(((....))).)))....(....)...))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...(...(((.....))).)....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....((((((..........))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.......... Structures of the bacterial ribosome in classical and hybrid states of tRNA binding; 16S rRNA 4v9d AV 76 3.0 RF00005 URS00005AA258_83333 21596992 0030533 0006412 83333 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).(((((.......))))).....(((((..]....)))))))))))).... Structures of the bacterial ribosome in classical and hybrid states of tRNA binding; phenylalanine specific transfer RNA 4v9d AX 15 3.0 21596992 268588 aggagguaaaauucu ............... ............... Structures of the bacterial ribosome in classical and hybrid states of tRNA binding; messenger RNA 4v9d BA 1539 3.0 RF00177,RF01959,RF01960 URS000080DDC0_562 21596992 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<<....>>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<...<....>.>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<.<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>.............>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<...<<<.....>>>.>.....>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>..>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((((....))))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....(((.((..((....)))).))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((.(....).)).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((((.......)))))))).....)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..((.((..((((((((((......((........))..........(((((((..(...((((((....((((((....))))))...............)))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..(....(((....)))....)....))).....)))))))......(....(((((((........)))))))....)..)..)).)).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Structures of the bacterial ribosome in classical and hybrid states of tRNA binding; 16S rRNA 4v9d BV 76 3.0 RF00005 URS00005AA258_83333 21596992 0030533 0006412 83333 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).(((((.......))))).....(((((..]....)))))))))))).... Structures of the bacterial ribosome in classical and hybrid states of tRNA binding; phenylalanine specific transfer RNA 4v9d BX 16 3.0 21596992 268588 aaggagguaaaauucu ................ ................ Structures of the bacterial ribosome in classical and hybrid states of tRNA binding; messenger RNA 4v9d CA 2897 3.0 RF02540,RF02541 URS000080E25C_562 21596992 0003735 0005840 562 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Structures of the bacterial ribosome in classical and hybrid states of tRNA binding; 23S rRNA 4v9d CB 119 3.0 RF00001 URS000080E133_83333 21596992 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>> ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))) Structures of the bacterial ribosome in classical and hybrid states of tRNA binding; 5S rRNA 4v9d DA 2896 3.0 RF02540,RF02541 URS000080E25C_562 21596992 0003735 0005840 562 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Structures of the bacterial ribosome in classical and hybrid states of tRNA binding; 23S rRNA 4v9d DB 118 3.0 RF00001 URS0000366A67_83333 21596992 0003735 0005840 83333 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))). Structures of the bacterial ribosome in classical and hybrid states of tRNA binding; 5S rRNA 4v9f 0 2808 2.404 RF02540,RF00002 URS000080E02E_272569 23695244,10937989 0003735 0005840 272569 acuaugccagcugguggauugcucggcucaggcgcugaugaaggacgugccaagcugcgauaagcuguggggagccgcacggaggcgaagaaccacagauuuccgaaugagaaucucucuaacaauugcuucgcgcaaugaggaaccccgagaacugaaacaucucaguaucgggaggaacagaaaacgcaacgugaugucguuaguaaccgcgagugaacgcgauacagcccaaaccgaagcccucacgggcaauguggugucagggcuaccucucaucagccgaccgucuucacgaagucucuuggaauagagcgugauacagggugacaaccccguacugaagaccaguacgcugugcgguagugccagaguagcggggguuggauaucccucgcgaauaacgcaggcaucgacugcgaaggcuaaacacaaccugagaccgauagugaacaaguagugugaacgaacgcugcaaaguacccucagaagggaggcgaaauagagcaugaaaucaguuggcgaucgagcgacagggcauacaaggucccuugacgaaugaccgagacgcgagucuccaguaagacucacgggaagccgauguucugucguacguuuugnaaaacgagccagggagugugucuguauggcaagucuaaccggaguauccggggaggcacagggaaaccgacauggccgcagggcuuugcccgagggccgccgucuucaagggcggggagccauguggacacgacccgaauccggacgaucuacgcauggacaagaugaagcgugccgaaaggcacguggaagucuguuagaguugguguccuacaauacccucucgugaucuauguguaggggugaaaggcccaucgaguccggcaacagcugguuccaaucgaaacaugucgaagcaugaccuccgccgagguagucugugagguagagcgaccgauugguguccuccugucaaacuccaaacuuacagacgcuguuugacgcggggauuccggugcgcgggguaagccuguguaccaggaggggaacaacccagagauagguuaagguccccaaguguggauuaaguguaauccucugaagguggucucgagcccuagacagccgggaggugagcuuagaagcagcuacccucuaagaaaagcguaacagcuuaccggccgagguuugaggcgcccaaaaugaucgggacucaaauccaccaccgagaccuguccguaccacucauacugguaaucgaguagauuggcgcucuaauuggauggaagcaggggcgagagcuccuguggaccgauuagugacgaaaauccuggccauaguagcagcgauagucgggugagaaccccgacggccuaauggauaaggguuccucagcacugcugaucagcugaggguuagccgguccuaagucucaccgcaacucgacugagacgaaaugggaaacagguuaauauuccugugccaucaugcagugaaaguugacgcccuggggucgaucacgccgggcauucgcccggucgaaccguccaacuccguggaagccguaauggcaggaagcggacgaacggcggcauagggaaacgugauucaaccuggggcccaugaaaagacgagcaugauguccguaccgagaaccgacacagguguccauggcggcgaaagccaaggccugucgggagcaaccaacguuagggaauucggcaaguuagucccguaccuucggaagaagggaugccugcuccggaacggagcaggucgcagugacucggaagcucggacugucuaguaacaacauaggugaccgcaaauccgcaaggacucguacggucacugaauccugcccagugcagguaucugaacaccucguacaagaggacgaaggaccugucaacggcggggguuaugacccucuuaagguagcguaguaccuugccgcaucaguagcggcuugcaugaauggauuaaccagagcuucacugucccaacguugggcccggugaacuguacauuccagugcggagucuggagacacccagggggaagcgaagacccuauggagcuuuacugcaggcugucgcugagacguggucgccgaucggugacugcgacucucacuccgggaggaggacaccgauagccgggcaguuugacuggggcgguacgcgcucgaaaagauaucgagcgcgcccuauggucaucucagccgggacagagacccggcgaagagugcaagagcaaaagaugacuugacaguguucuucccaacgaggaacgcugacgcgaaagcguggucuagcgaaccaauuagccugcuugaugcgggcaauugaugacagaaaagcuacccuagggauaacagagucgucacucgcaagagcacauaucgaccgaguggcuugcuaccucgaugucgguucccuccauccugcccgugcagaagcgggcaagggugaggunnuucgccuauuaaaggaggucgugagcugggnuuagaccgucgugagacaggucggcugcuaucuacuggguguguaauggugucugacaagaacgaccguauaguacgagaggaacuacgguugguggccacugguguaccgguuguucgagagagcacgugccggguagccacgccacacgggguaagagcugaacgcaucuaagcucgaaacccacuuggaaaagagacaccgccgaggucccgcguacaagacgcggucgauagacucggggugugcgcgucgagguaacgagacguuaagcccacgagcacuaacagaccaaagc ....<<<<<<<<<<<.....((..((<<<<<<.[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<...>>>.......<<<<<.....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>...<<<<<.....<<.....>>....>>>>>...<<<...<<<...<<<<....>>>>.....>>>....<<<<<<<<......<<<<.....<<<<<<<......<<<<......>>>>.((......<<<.....))>>>....>>>>>>>......>>>>...>>>>>>.>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......]..>>>>>>.))...............<<....>>....))..........<<<.....>>>...................>>>>>>>>>>>.......<<<<<<<<<<....<.<<<<.<<<.........<<<<<....>>>>>.........>>>.>>>>...>.>>>>>>>>>>...<<<........>>>.<<<<<<...<<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<<...<<<<...>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>>.<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<...<<<.<<<<<<<<<...<<<.....<<..<<......>>..>>...>>.>...>>>>>>>>>>>>.......>>>>>>..>..<<<<<<.<<<.....>>>.>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...........<<<.<<<<<<<<<<.......<<<<<.<<<..<<<<.......>>>>..>>>.......<<<<......>>>>.>>>>>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>..>>....>>>>>><...<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>....>.....>>>>>><<.....<........<<<<<<.......>>>>>><<<<<...<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<.<<.....>>..>>>>>>.....>>>..<<<<<........>>>>>))<<<<<<<<.......<<<...<<<<<<<<...<<<<<<<<<<<<<.(((>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>>>.....>>>>>....>......>>>>>>...>>>>>>>>.........>>>..>>>>>>>>.>>>..>>.....<<......>>.>>>>..<<<.......>>>.>>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<.....>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<.....<<<<......>>>>.....>>>>>>>>..>>>>><<<<<<....>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>....>>.((.<<<<<<......))>>>>>>.<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<<.<<<<<<<<<<<..>>>>>>>>>>>.>>>...<<<<....>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>..>>>..<<<<.....>>>>......>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>.....<<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<<<<...<<<<<<<<<<))).>>>>>...>>>>>...>>>>.>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>....<<<<<<<<<.......>>>>>....<<<.<<<<<<<<....<<<<<..........>>>>>...>>>>.>>>>..>>>...>>>>..... .....(((((((((.....(((..((((((((.(((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((...)))(...)..(((((.....))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))...((((...((..(((((....))))....))).....((((((((......((((.....(((((((....({((((......)))))[[(...).(((....}]])))....)))))))......))))...)))))).)).)....(((((((........)))))))......(((((.[[[[[[)))))..)))......)..)))))).))...............((....))....))......(...(((.....))).............)).....)))))))))......(.((((((((((....((((((.(((....(....(((((....))))).....)...))).))))..)).)))))))))).<.(((........))).((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((...))))...)))))((((((....))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))..((((((...(((.(((((((((...(((.....((..((......))..))...)).)...)))))))))))).......)))))).....((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((...........(((.((((((((((.....{.(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))))))))))))..........]]]))....))))))))))...)))))))(((((((.......)))))..))....))))))(.(.((((((((......((((((((....))))))))...)))))))).)..).....))))))((.....((.......((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.((...((((((.((.....))..)))))).....))...(((((........)))))]]((((((((.......(((...((((((((...(((((((((((((..{{)))))))(...(((((....(((((....(((.....))).....))))).....)))))....)(....)))))))...))))))))(...)....)))..)))))))).))).))).....((......)).))))..(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.....)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))((((........))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)))[[..(((((.....>]])))))..(((((((..(((.((......((((.((((((..(((((.((((((((..(((.(((.((.(........).)).))).)))...((((....)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..))).)))))))......((((((...((((..((((((((.....(....)....))))))))(((((...((((...((((((((((}}..)))))...)))))...)))).)))))..(((....((((.....}.......))))....))).)))).......)))))).....(((((((((.......)))))....(((.((((((((....(((((..(....)..)))))...)))).))))..)))...))))..... The re-refined crystal structure of the Haloarcula marismortui large ribosomal subunit at 2.4 Angstrom resolution: more complete structure of the L7/L12 and L1 stalk, L5 and LX proteins; 23S Ribosomal RNA 4v9f 9 122 2.404 RF00001 URS00000A7E81_272569 23695244,10937989 0003735 0005840 272569 uuaggcggccacagcggugggguugccucccguacccaucccgaacacggaagauaagcccaccagcguuccagggaguacuggagugcgcgagccucugggaaauccgguucgccgccacc ...<<<<<<....<<<<<<<<......<<<<<...............>>>..>>....>>>>>>.>><..<<.<<.....<<<<<<.<<....>>>>>>>>....>>.>>.>.>>>>>>... ...((((((....((((((((......((((((...(.....)...))))..))....)))))).))...((.(......((((((.((....)))))))).....).))...))))))... The re-refined crystal structure of the Haloarcula marismortui large ribosomal subunit at 2.4 Angstrom resolution: more complete structure of the L7/L12 and L1 stalk, L5 and LX proteins; 5S Ribosomal RNA 4v9h AA 1514 2.857 RF00177,RF01959,RF01960 URS000080E2E6_300852 23812720 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgaggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucaccuccuuuc ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<.........>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>..........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>.................>>>>>>>>.<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<...<<<..<<<.....>>>>>>....>>>>>>.....<<<<<....>>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>............<<<<<<........>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((.........)))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....)......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((.(...(((((((....)))))))...................))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(.....((((((........))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.............. Crystal structure of the ribosome bound to elongation factor G in the guanosine triphosphatase state; 16S ribosomal RNA 4v9h AV 74 2.857 RF00005 URS00005AA258_562 23812720 0030533 0006412 562 gcccggauagcucaggguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((.(...[..).))..((((.......))))......(((((..]....)))))))))))).... Crystal structure of the ribosome bound to elongation factor G in the guanosine triphosphatase state; PE hybrid state tRNA Phe 4v9h BA 2859 2.857 RF02540,RF02541,RF00002 URS000080E0F3_300852 23812720 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucgggggcccucggccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggcguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu .<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<..>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>.....<<<<<<<<...<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>..>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<...<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<........>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..<<<.......>>>...>>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<.>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<.......>>>.>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<.......>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>. .........((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((....))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(((((((((...((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))..))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))..)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((.(.(.((((......))))..))..)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{..((((.(((..................))).....(...(........).).))))....)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.((...{{....))))))(((...((((((((((.(((((.((.....))))))).).....)))))))))..)))(...(((.))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((((.......)))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((...........).))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((((.((((..{.....[..(((.(..(((......(.((.(.(...}).).)).)...)))..........].).)))..)))).)))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))...(.......).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....... Crystal structure of the ribosome bound to elongation factor G in the guanosine triphosphatase state; 23S ribosomal RNA 4v9h BB 119 2.857 RF00001 URS00005AB4A7_300852 23812720 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>> .((((((((((....(((((.((....(((((((...(.....)...))))..)))...)).))).))(((.......((.(((((....))))).)).......))).)))))))))) Crystal structure of the ribosome bound to elongation factor G in the guanosine triphosphatase state; 5S ribosomal RNA 4v9i AA 1504 3.3 RF00177,RF01959,RF01960 URS000080E260_300852 23812587 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<.........>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<.....>>.....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<....<<.....>>.>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<<..>>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((.(((.........))).)))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((......((.(((....))).)).....................)))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...(..............).....))))))).....(((.(....).)))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((...(..((((....))))..).....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Crystal structure of thermus thermophilus 70S in complex with tRNAs and mRNA containing a pseudouridine in a stop codon; 16S ribosomal RNA 4v9i AV 77 3.3 RF00005 URS000041AF00_562 23812587 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of thermus thermophilus 70S in complex with tRNAs and mRNA containing a pseudouridine in a stop codon; P-SITE tRNA 4v9i AW 76 3.3 RF00005 URS00005AA258_562 23812587 0030533 0006412 562 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((.........)))).......(((..]....)))..))))))).... Crystal structure of thermus thermophilus 70S in complex with tRNAs and mRNA containing a pseudouridine in a stop codon; E-SITE tRNA 4v9i AY 75 3.3 URS000080E218_562 23812587 0030533 0006412 562 ggagagaugccggagcggcugaaggaccggucucgaaaaccggaguaggggcaacucuaccggggguucaaaucc ...<<<...<<............>>..<<<<.......>>>>.........<.........>....>>>...... ..........(............)....(((.......)))..........(.........)............. Crystal structure of thermus thermophilus 70S in complex with tRNAs and mRNA containing a pseudouridine in a stop codon; A-SITE tRNA 4v9i BA 2807 3.3 RF02540,RF02541,RF00002 URS000080DDD0_300852 23812587 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucgggggcccucggccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccagucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<..>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>.....<<<<<<<<...<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>..>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<...<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<....>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...........>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<.........>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (........((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((....))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((((((((..).))))))))....((((((((....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))...)))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((((((((....)))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))..)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((.(.((((((......)))).)))..)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((((((......{...........))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.((...{{....))))))(((...((((((((((.(((((.((.....))))))).).....)))))))))..)))(...........))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((((.......)))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((((.((((........[..(((((..(((......(((((.((....)).)))))...)))..........].)))))..)))).)))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))...(.........).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))......) Crystal structure of thermus thermophilus 70S in complex with tRNAs and mRNA containing a pseudouridine in a stop codon; 23S ribosomal RNA 4v9i BB 119 3.3 RF00001 URS000080DE2B_300852 23812587 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>> .((((((((((....(((((.((....(((((((...(.....)...))))..)))...)).))).))(((.......((.(((((....))))).)).......))).)))))))))) Crystal structure of thermus thermophilus 70S in complex with tRNAs and mRNA containing a pseudouridine in a stop codon; 5S ribosomal RNA 4v9i CA 1504 3.3 RF00177,RF01959,RF01960 URS000080E260_300852 23812587 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<.........>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<.....<<<<<<<....>>>>>>>....<<.....>>.......>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<....<<.....>>.>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<<..>>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((.(((.........))).)))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((......((.(((....))).)).....................)))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..((..............).)...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Crystal structure of thermus thermophilus 70S in complex with tRNAs and mRNA containing a pseudouridine in a stop codon; 16S ribosomal RNA 4v9i CV 77 3.3 RF00005 URS000041AF00_562 23812587 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of thermus thermophilus 70S in complex with tRNAs and mRNA containing a pseudouridine in a stop codon; P-SITE tRNA 4v9i CW 76 3.3 RF00005 URS00005AA258_562 23812587 0030533 0006412 562 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... ((((.....((((........))))..((...........).).....(.((.........)).)...)))).... Crystal structure of thermus thermophilus 70S in complex with tRNAs and mRNA containing a pseudouridine in a stop codon; E-SITE tRNA 4v9i CY 75 3.3 URS000080E218_562 23812587 0030533 0006412 562 ggagagaugccggagcggcugaaggaccggucucgaaaaccggaguaggggcaacucuaccggggguucaaaucc ...<<<...<<............>>..<<<<.......>>>>.........<.........>....>>>...... ..........(............)....(((.......)))..........(.........)............. Crystal structure of thermus thermophilus 70S in complex with tRNAs and mRNA containing a pseudouridine in a stop codon; A-SITE tRNA 4v9i DA 2807 3.3 RF02540,RF02541,RF00002 URS000080DDD0_300852 23812587 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucgggggcccucggccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccagucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<..>>>>>>.>>....<<<<<.....<<....>>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>.....<<<<<<<<...<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>..>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<...<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<..................>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...........>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<.........>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (........((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((....))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((((((((..).))))))))....((((((((.....(...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)....)))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((((((((....)))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))..)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((.(.((((((......)))).)))..)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((((((......{...........))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.((...{{....))))))(((...((((((((((.(((((.((.....))))))).).....)))))))))..)))(...........))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((((.......)))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((((.((((...........(((((..(((......((((((((....))))))))...)))............)))))..)))).)))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))...(.........).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))......) Crystal structure of thermus thermophilus 70S in complex with tRNAs and mRNA containing a pseudouridine in a stop codon; 23S ribosomal RNA 4v9i DB 119 3.3 RF00001 URS000080DE2B_300852 23812587 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>> .((((((((((....(((((.((....(((((((...(.....)...))))..)))...)).))).))(((.......((.(((((....))))).)).......))).)))))))))) Crystal structure of thermus thermophilus 70S in complex with tRNAs and mRNA containing a pseudouridine in a stop codon; 5S ribosomal RNA 4v9j AA 1511 3.86 RF00177,RF01959,RF01960 URS000080DFCE_262724 23812722 0003735 0005840 262724 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgaggaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucaccuc ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<<.....>>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>....<<<<.<<<<<....>>>>>.>>>>...<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<(......<<<<...<<<.<<<<<<.<<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>..>>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>...<<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..>.......<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<...)>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<......>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>.......... ....((((..[.[[[..)))).((((.(((((..(((((((((.....((.(((..(((..((.(.((.(((((.....))))).)).).)))))......(((......(((((((...((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))..).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((....((((((((((......((........))..........(((((((..(...((((((((..(((((((....)))))))...((((....))))..))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..((...(((.....)))).)...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)....))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}......... 70S ribosome translocation intermediate GDPNP-II containing elongation factor EFG/GDPNP, mRNA, and tRNA bound in the pe*/E state.; 16S ribosomal RNA 4v9j AV 18 3.86 23812722 262724 aaggagguaaaaauggua .................. .................. 70S ribosome translocation intermediate GDPNP-II containing elongation factor EFG/GDPNP, mRNA, and tRNA bound in the pe*/E state.; messenger RNA 4v9j AW 77 3.86 RF00005 URS0000093D11_562 23812722 0030533 0006412 562 ggcuacguagcucaguugguuagagcacaucacucauaaugauggggucacagguucgaaucccgucguagccacca <<<<<<<..<<<...........>>>.<<<<<.......>>>>>.....<<.<<.......>>.>>>>>>>>>.... (((((((..(((...........))).(((((.......)))))........((.......))...))))))).... 70S ribosome translocation intermediate GDPNP-II containing elongation factor EFG/GDPNP, mRNA, and tRNA bound in the pe*/E state.; tRNA-Met 4v9j BB 119 3.86 RF00001 URS000080DE2B_262724 23812722 0003735 0005840 262724 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>> .((((((.(((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).))).)))))) 70S ribosome translocation intermediate GDPNP-II containing elongation factor EFG/GDPNP, mRNA, and tRNA bound in the pe*/E state.; 5S ribosomal RNA 4v9j BA 2879 3.86 RF02540,RF02541,RF00002 URS000080DEC7_262724 23812722 0003735 0005840 262724 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgucuaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaaaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagcuccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagacuacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<.))..))..>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.....>>>>>>.>>....<<<<<.....<<....>>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<..<<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>>.>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..<<<<>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<...<<<...<<<.....>>>...>>>...<<....>>..<<<.......>>>......>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<....<<...<<<<<<<<...<<<<.........>>..>>...>>>>>>>>..>>.....>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<((......<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..<<<<.......>>>>..>>>.........<<......>>...>>>>>....>>>>>>>>>.>>...........))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><<<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>.>>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>....<<<<........>>>>.))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..((((...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>....>>>>>>>>>..>>><....<<<....>>>......>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>......<<<<........>>>>...<<<<<<<<.<<<..<......<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<.<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>.>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<.......>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..>>>>..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<.<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>...>...>>>.>>....<<<<<<<....>>>.>>>>....>...>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))))>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<.......>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((........((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...((((((((.....))))))))....{.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).))))....(((((((((.[.....)))))))))....}.(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))).......(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...((((((((....(((...(((.((((.(.((((((......)))).)))..)))).)))..)).)....))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((.(.....{.(((((.(((..(((.........)))..))).....(...((......)).).)))))...).)))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(((((((...(((......(((((.(((....))))))))...)))..))))).)).....))))))(......((.....((((((.......))))))((((....((((..((.([((((((...((.....)).)))))))...[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....((((..(((..(((((.((((.((...{{....))))))(((...((((((((.(((((((.((.....))))))))).....))))))))..)))(....(((....)))......))))))...)))...))))(..).....))))...))...))))))))))))))).])).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(....).....)))))(((((((((((.......)))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......)))))))..((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.((.((.((((((((((((((((.(.........(((((..(((......(((((.((....)).)))))...)))............)))))).))))))))))))))))...(((((....)))))....)).)).)))..)))))..((.......[.))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....((.((((.((..]]]]..)))))).)).....)}......))))..))))))......(((((...((((((...((.......))...))))))....))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))...(((.....))).....(((((((((.......)))))....(((.((((..((....(((((....)))))...))...))))..)))...))))....))) 70S ribosome translocation intermediate GDPNP-II containing elongation factor EFG/GDPNP, mRNA, and tRNA bound in the pe*/E state.; 23S ribosomal RNA 4v9j CA 1511 3.86 RF00177,RF01959,RF01960 URS000080DFCE_262724 23812722 0003735 0005840 262724 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgaggaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucaccuc ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<<.....>>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>....<<<<.<<<<<....>>>>>.>>>>...<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<.<<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>.>..........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<...<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<......>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<...<<<.....>>>>.>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>......>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>.......... ....(((...[.[[[...))).((((.(((((..(((((((((.....((.(((..(((..((.(.((((((((.....)))))))).).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))..).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((.(.((((((((((......((((((.....))))))....))))))))..))).)))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((.(((((......((........))..........(((((((..(...((((((((..(((((((....)))))))...((((....))))..))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..((...(((.....)))).)...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).))).)))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}......... 70S ribosome translocation intermediate GDPNP-II containing elongation factor EFG/GDPNP, mRNA, and tRNA bound in the pe*/E state.; 16S ribosomal RNA 4v9j CV 18 3.86 23812722 262724 aaggagguaaaaauggua .................. .................. 70S ribosome translocation intermediate GDPNP-II containing elongation factor EFG/GDPNP, mRNA, and tRNA bound in the pe*/E state.; messenger RNA 4v9j CW 77 3.86 RF00005 URS0000093D11_562 23812722 0030533 0006412 562 ggcuacguagcucaguugguuagagcacaucacucauaaugauggggucacagguucgaaucccgucguagccacca .<<<<<<..<<<...........>>>.<<<<<.......>>>>>.....<<.<<.......>>.>>>>>>>>..... (((((((..(((...........))).(((((.......)))))........((.......))...))))))).... 70S ribosome translocation intermediate GDPNP-II containing elongation factor EFG/GDPNP, mRNA, and tRNA bound in the pe*/E state.; tRNA-Met 4v9j DB 119 3.86 RF00001 URS000080DE2B_262724 23812722 0003735 0005840 262724 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).)))))))))) 70S ribosome translocation intermediate GDPNP-II containing elongation factor EFG/GDPNP, mRNA, and tRNA bound in the pe*/E state.; 5S ribosomal RNA 4v9j DA 2879 3.86 RF02540,RF02541,RF00002 URS000080DEC7_262724 23812722 0003735 0005840 262724 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgucuaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaaaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagcuccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagacuacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.....>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..<<<<>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<.........>>..>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<((......<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..<<<<.......>>>>..>>>.........<<......>>...>>>>>....>>>>>>>>>.>>...........))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..((((...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>....>>>>>>>>>..>>><....<<<....>>>......>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<..<......<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..>>>>..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<.<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>...>...>>>.>>....<<<<<<<....>>>.>>>>....>...>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))))>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<.......>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> ((.......(((((((((......(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...((((((((.....))))))))....{.(((((((((....(((...(((((..(((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))...)))))..))))))))).))))....(((((((((.[.....)))))))))....}.(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............))......))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((.(..(((...(((.....)))...)))...((....))..((((.....)))).....).)))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((.(...(((((((((...(((...(((.((((.(.((((((......)))).)))..)))).)))..)).)...)))))))))..)..))))))).)...(((((((..(......)..))))))).....(((......)))...((((.(((...((([[[.....((((((.....(.....((..((((((((((.....{.(((((.(((..(((.........)))..))).....(...((......)).).)))))...)))))))))).))..........]]].)....)))))).)))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.((...{{....))))))(((...((((((((((((((((.((.....)))))))))....)))))))))..)))(....(((....)))......))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....))....(((((.....]..)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((.((((((.(.........(((((..(((......((((((((....))))))))...)))............)))))).)))))).)))))))))...(((((....)))))....))))).)))..)))))..(((.......)))((((((...........))))))([((...((.((((.(.(((((.........)))))...).((][.[[[))....)))).))...((((..(((...{..)))..)))).(((....))).))]]].].....((.((((.((..]]]]..)))))).)).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...((((((....((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..].....))))))...(((.....))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...)))).....)) 70S ribosome translocation intermediate GDPNP-II containing elongation factor EFG/GDPNP, mRNA, and tRNA bound in the pe*/E state.; 23S ribosomal RNA 4v9k AA 1511 3.5 RF00177,RF01959,RF01960 URS000080DFCE_262724 23812722 0003735 0005840 262724 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgaggaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucaccuc ....<<<<..{.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<.<<.....>>.>>>>>>>.>>>>>......<<..<....<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>....<<<<.<<<<<....>>>>>.>>>>...<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<.[[.>>>>...>>>>>>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<........))).........>>>>>>>>>>..>>>>>>>>>.......]].<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<....<<<......>>>.......>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).}<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<.......<<<<<<...<<<<<<<....>>>>>>>...<<<......>>>...>>>>>>..<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.......... ....(((...[.[[[...))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.....)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((.(((....)))....))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((.(((....))).)))...((((....))))...)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..((...(((.....)))).)...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}......... 70S ribosome translocation intermediate GDPNP-I containing elongation factor EFG/GDPNP, mRNA, and tRNA bound in the pe*/E state.; ribosomal RNA 16S 4v9k AW 77 3.5 RF00005 URS0000093D11_562 23812722 0030533 0006412 562 ggcuacguagcucaguugguuagagcacaucacucauaaugauggggucacagguucgaaucccgucguagccacca <<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<.<<.......>>.>>>>>>>>>.... (((((((..((((.........)))).(((((.......))))).....((.((.......)).))))))))).... 70S ribosome translocation intermediate GDPNP-I containing elongation factor EFG/GDPNP, mRNA, and tRNA bound in the pe*/E state.; transfer RNA 4v9k AV 23 3.5 23812722 262724 aaggagguaaaaaugguaaaaaa ....................... ....................... 70S ribosome translocation intermediate GDPNP-I containing elongation factor EFG/GDPNP, mRNA, and tRNA bound in the pe*/E state.; messenger RNA 4v9k BA 2879 3.5 RF02540,RF02541,RF00002 URS000080DEC7_262724 23812722 0003735 0005840 262724 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgucuaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaaaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagcuccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagacuacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....[[..[[<<<<<<[[<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<<<<<.....>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...(((....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>.]]...............<<....>>....]].........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<.......>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<........>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..((((...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>....>>>>>>>>>..>>><....<<<....>>>......>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.........<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<.(((..>>>>..)))>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<.<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>..>....<<<<<<<....>>>.>>>>........)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))))>>>>>>...>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>...<<<.....>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> ((........(((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.....)))))).))...((((((.....(...[..)......))))).).........((....))...((((......((.]...)).....))))...((((...((((((((.....))))))))....{.(((.(((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))..))))....(((((((((.[.....)))))))))....}..((((].[[[[))))...)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))......(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..(.((.....)).).....)))))))))))))..((.(...((((((.....(((((.((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))).))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...((((((((....(((...(((.((((...((.(((......)))..))...)))).)))..)).)....))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((..(((.........)))..))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(((((((...(((......(((((.(((....))))))))...)))..))))).)).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....((((..(((..(((((.((((.((...{{....))))))(((...((((((((((((((((.((.....)))))))))....)))))))))..)))(....(((....)))......))))))...)))...))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(.(((.........))).)........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....))....(((((.....]..)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........(((((..(((......((((((((....))))))))...)))............)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))...(((.....))).....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...)))).....)) 70S ribosome translocation intermediate GDPNP-I containing elongation factor EFG/GDPNP, mRNA, and tRNA bound in the pe*/E state.; 23S ribosomal RNA 4v9k BB 119 3.5 RF00001 URS000080DE2B_262724 23812722 0003735 0005840 262724 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<<....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).)))))))))) 70S ribosome translocation intermediate GDPNP-I containing elongation factor EFG/GDPNP, mRNA, and tRNA bound in the pe*/E state.; 5S ribosomal RNA 4v9k CA 1511 3.5 RF00177,RF01959,RF01960 URS000080DFCE_262724 23812722 0003735 0005840 262724 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgaggaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucaccuc ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<.<<.....>>.>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>....<<<<.<<<<<....>>>>>.>>>>...<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<..[.>>>>...>>>>.>>.<<<<<............>>>>>.<<<<....>>>>...>>>>>>>.....<..<<<....<<<<....>>>>..>>>.>>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<........))).........>>>>>>>>>>..>>>>>>>>>.......]..<<<((.....<<<<...<<<.<<<<<<.<<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<.<..<<<<<<<....<<<......>>>.......>>>>>>>...>.......<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<........<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>...<<<......>>>...>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<...<<<.....>>>.>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>......>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>.......... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((.(((.........))).)))).)))))......(((......((((((((..((...(((((((.(((((....((((.(....).)))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((.(((....)))....))))))).(((((............))))).((((....))))...)))))).).....(.(((...(.(((....)))..))))).)).))))))..((((......((((....)))).....))))....(((((........((((.....))))..........)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.(((((((((.......((((((.....)))))).....)))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((((((....)))))))...(((......)))...)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...(...(((.....)))).....)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}......... 70S ribosome translocation intermediate GDPNP-I containing elongation factor EFG/GDPNP, mRNA, and tRNA bound in the pe*/E state.; ribosomal RNA 16S 4v9k CW 77 3.5 RF00005 URS0000093D11_562 23812722 0030533 0006412 562 ggcuacguagcucaguugguuagagcacaucacucauaaugauggggucacagguucgaaucccgucguagccacca <<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<.<<.......>>.>>>>>>>>>.... .((((((..((((.....[...)))).(((((.......))))).....((.((..]....)).))))))))..... 70S ribosome translocation intermediate GDPNP-I containing elongation factor EFG/GDPNP, mRNA, and tRNA bound in the pe*/E state.; transfer RNA 4v9k CV 23 3.5 23812722 262724 aaggagguaaaaaugguaaaaaa ....................... ....................... 70S ribosome translocation intermediate GDPNP-I containing elongation factor EFG/GDPNP, mRNA, and tRNA bound in the pe*/E state.; messenger RNA 4v9k DA 2879 3.5 RF02540,RF02541,RF00002 URS000080DEC7_262724 23812722 0003735 0005840 262724 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgucuaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaaaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagcuccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagacuacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....[[..[[<<<<<<[[<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<<<<<.....>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...(((....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>.]]...............<<....>>....]].........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<........>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..<<<<.......>>>>..>>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><<<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>.>>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..((((...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.........<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<.(((..>>>>..)))>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))))>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<<.....>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> .(........(((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((.(((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))..)))]....(((((((((.[.....)))))))))....)..((((].[[[[))))...)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))......(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((.(.((.(((......)))..)))..)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((........((((.(((..(((.........)))..))).....(...((......)).).))))....)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.((...{{....))))))(((...((((((((((((((((.((.....)))))))))....)))))))))..)))(....(((....)))......))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....))....(((((.....]..)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........(((((..(((......((((((((....))))))))...)))............)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))(.((...(((((((.(.(((((.........)))))...).((.[.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((.(((..(((((((((......))))))..))).(((((.....))))).....))).)..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))...(((.....))).....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...)))).....). 70S ribosome translocation intermediate GDPNP-I containing elongation factor EFG/GDPNP, mRNA, and tRNA bound in the pe*/E state.; 23S ribosomal RNA 4v9k DB 119 3.5 RF00001 URS000080DE2B_262724 23812722 0003735 0005840 262724 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<<....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>> .((((((((((....((((((((....(((((((.............))))..)))...)))))).))(((.......((.(((((....))))).)).......))).)))))))))) 70S ribosome translocation intermediate GDPNP-I containing elongation factor EFG/GDPNP, mRNA, and tRNA bound in the pe*/E state.; 5S ribosomal RNA 4v9l AA 1511 3.5 RF00177,RF01959,RF01960 URS000080DFCE_262724 23812722 0003735 0005840 262724 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgaggaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucaccuc ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<.<<.....>>.>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>....<<<<.<<<<<....>>>>>.>>>>...<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>.....<<.<<<....<<<<....>>>>..>>>>>>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<....<<<......>>>.......>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<.......<<<<<<<..<<<<<<<....>>>>>>>...<<<......>>>..>>>>>>>..<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>.......... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(.((.(((((.....))))).)).).)))))......(((......(((.((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(.(((....))).).))))...((((...)))).)))))))..)))))).)))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.(((((((.((......((((((.....))))))....)).)))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((..((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((((..((((((......))))))...((((....))))..))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..((...(((.....)))).)...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))).))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((.(((((....))))).)))}......... 70S Ribosome translocation intermediate FA-3.6A containing elongation factor EFG/FUSIDIC ACID/GDP, mRNA, and tRNA bound in the pe*/E state.; ribosomal RNA 16S 4v9l AW 77 3.5 RF00005 URS0000093D11_562 23812722 0030533 0006412 562 ggcuacguagcucaguugguuagagcacaucacucauaaugauggggucacagguucgaaucccgucguagccacca <<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<.<<.......>>.>>>>>>>>>.... (((((((..(((...........))).(((((.......)))))........((.......))...))))))).... 70S Ribosome translocation intermediate FA-3.6A containing elongation factor EFG/FUSIDIC ACID/GDP, mRNA, and tRNA bound in the pe*/E state.; transfer RNA 4v9l AV 23 3.5 23812722 262724 aaggagguaaaaaugguaaaaaa ....................... ....................... 70S Ribosome translocation intermediate FA-3.6A containing elongation factor EFG/FUSIDIC ACID/GDP, mRNA, and tRNA bound in the pe*/E state.; messenger RNA 4v9l BA 2879 3.5 RF02540,RF02541,RF00002 URS000080DEC7_262724 23812722 0003735 0005840 262724 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgucuaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaaaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagcuccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagacuacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<.))..))..>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.....>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<((......<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..<<<<.......>>>>..>>>.........<<......>>...>>>>>....>>>>>>>>>.>>...........))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><<<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>.>>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>....>>>>>>>>>..>>><....<<<....>>>......>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>.>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<....<<..>>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>......<<<<........>>>>...<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<<.....>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> ((.......(((((((((......(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((..(((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))...)))))..))))))))).)))]....((((((((..[......))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............))......))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...((((((((....(((...(((.((((.(.((((((......)))).)))..)))).)))..)).)....))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((..(((.........)))..))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((.......((((.(((....)))))))....)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.((...{{....))))))(((...((((((((((((((((.((.....)))))))))....)))))))))..)))(....(((....)))......))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(.(((.........))).)........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).....((((.....]..))))...((((((((.(((..(......((((.(((.((..(((((.(((.(((((.(((((((((.((((((.(.........(((((..(((......((((((((....))))))))...)))............)))))).)))))).)))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....((.((((.((..]]]]..)))))).)).....)}......)).)..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((.(((..(((((((((......))))))..))).(((((.....))))).....))).)..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(.(((((.....(....)....))))).).(((((...(((....(((((((((((.}}.))))))...)))))....))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))...(((.....))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...)))).....)) 70S Ribosome translocation intermediate FA-3.6A containing elongation factor EFG/FUSIDIC ACID/GDP, mRNA, and tRNA bound in the pe*/E state.; 23S ribosomal RNA 4v9l BB 119 3.5 RF00001 URS000080DE2B_262724 23812722 0003735 0005840 262724 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).)))))))))) 70S Ribosome translocation intermediate FA-3.6A containing elongation factor EFG/FUSIDIC ACID/GDP, mRNA, and tRNA bound in the pe*/E state.; 5S ribosomal RNA 4v9l CA 1511 3.5 RF00177,RF01959,RF01960 URS000080DFCE_262724 23812722 0003735 0005840 262724 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgaggaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucaccuc ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<<.....>>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<.<<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<....<<<......>>>.......>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>...<<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..>.......<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<.......<<<<<<<..<<<<<<<....>>>>>>>...<<<......>>>..>>>>>>>..<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.......... ....((((..[.[[[..)))).((((.(((((..(((((((((.....((.(((..(((..((.(.((.(((((.....))))).)).).)))))......(((......(((.((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(.(((....))).).))))...((((...)))).)))))))..)))))).)))(((....(((..((((((((.......)))))))))))......)))..(((((((......)))...))))))).(((((............))))).((((....))))...)))))..).....(.(((....((((....))))..)))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((.(((((...))))).))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((..((((((.((..(((((..((((((((((......((........))........(.(((((((......((((((((..((((((......))))))...((((....))))..))))))))..((.(((...((((((......(((((((((....)))...(((......)))...)))))).....((((.(((((((..((...(((.....)))).)...)))))))..(..(((((....))))).....)..)))).......).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))).))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}......... 70S Ribosome translocation intermediate FA-3.6A containing elongation factor EFG/FUSIDIC ACID/GDP, mRNA, and tRNA bound in the pe*/E state.; ribosomal RNA 16S 4v9l CW 77 3.5 RF00005 URS0000093D11_562 23812722 0030533 0006412 562 ggcuacguagcucaguugguuagagcacaucacucauaaugauggggucacagguucgaaucccgucguagccacca <<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<.<<.......>>.>>>>>>>>>.... .((((((..(((...........))).(((((.......))))).....((.((.......)).))))))))..... 70S Ribosome translocation intermediate FA-3.6A containing elongation factor EFG/FUSIDIC ACID/GDP, mRNA, and tRNA bound in the pe*/E state.; transfer RNA 4v9l CV 23 3.5 23812722 262724 aaggagguaaaaaugguaaaaaa ....................... ....................... 70S Ribosome translocation intermediate FA-3.6A containing elongation factor EFG/FUSIDIC ACID/GDP, mRNA, and tRNA bound in the pe*/E state.; messenger RNA 4v9l DA 2879 3.5 RF02540,RF02541,RF00002 URS000080DEC7_262724 23812722 0003735 0005840 262724 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgucuaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaaaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagcuccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagacuacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu .<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.....>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..<<<<.......>>>>..>>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><<<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>.>>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>....>>>>>>>>>..>>><....<<<....>>>......>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>......<<<<........>>>>...<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<.<.<<.......>>..>>>>>>>....>>>.>.......<.<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>..>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<<.....>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>. .(.......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((..(((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))...)))))..))))))))).)))]....((((((((..[......))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..((....(((.....)))....))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((.(.((.(((......)))..)))..)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......(((((.(((..(((.........)))..))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((.......((((.(((....)))))))....)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.((...{{....))))))(((...((((((((((((((((.((.....)))))))))....)))))))))..)))(....(((....)))......))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....))....(((((.....]..)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........(((((..(((......((((((((....))))))))...)))............)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(.(((((.....(....)....))))).).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))...(((.....))).....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...)))).....). 70S Ribosome translocation intermediate FA-3.6A containing elongation factor EFG/FUSIDIC ACID/GDP, mRNA, and tRNA bound in the pe*/E state.; 23S ribosomal RNA 4v9l DB 119 3.5 RF00001 URS000080DE2B_262724 23812722 0003735 0005840 262724 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).)))))))))) 70S Ribosome translocation intermediate FA-3.6A containing elongation factor EFG/FUSIDIC ACID/GDP, mRNA, and tRNA bound in the pe*/E state.; 5S ribosomal RNA 4v9m AA 1511 4.0 RF00177,RF01959,RF01960 URS000080DFCE_262724 23812722 0003735 0005840 262724 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgaggaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucaccuc ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<.<<.....>>.>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>....<<<<.<<<<<....>>>>>.>>>>...<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<....<<<......>>>.......>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<.......<<<<<<<..<<<<<<<....>>>>>>>...<<<......>>>..>>>>>>>..<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>.......... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(.((.(((((.....))))).)).).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(.(((....))).).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(.(((....)))..))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.(((((((.((......((((((.....))))))....)).)))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((..((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((((..((((((......))))))...((((....))))..))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..((...(((.....)))).)...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))).))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}......... 70S Ribosome translocation intermediate FA-4.2A containing elongation factor EFG/FUSIDIC ACID/GDP, mRNA, and tRNA bound in the pe*/E state.; ribosomal RNA 16S 4v9m AW 77 4.0 RF00005 URS0000093D11_562 23812722 0030533 0006412 562 ggcuacguagcucaguugguuagagcacaucacucauaaugauggggucacagguucgaaucccgucguagccacca <<<<<<<..<<<...........>>>.<<<<<.......>>>>>.....<<.<<.......>>.>>>>>>>>>.... (((((((..(((...........))).(((((.......)))))........((.......))...))))))).... 70S Ribosome translocation intermediate FA-4.2A containing elongation factor EFG/FUSIDIC ACID/GDP, mRNA, and tRNA bound in the pe*/E state.; transfer RNA 4v9m AV 23 4.0 23812722 262724 aaggagguaaaaaugguaaaaaa ....................... ....................... 70S Ribosome translocation intermediate FA-4.2A containing elongation factor EFG/FUSIDIC ACID/GDP, mRNA, and tRNA bound in the pe*/E state.; messenger RNA 4v9m BA 2879 4.0 RF02540,RF02541,RF00002 URS000080DEC7_262724 23812722 0003735 0005840 262724 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgucuaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaaaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagcuccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagacuacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu .<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<.))..))..>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.....>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<((......<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..<<<<.......>>>>..>>>.........<<......>>...>>>>>....>>>>>>>>>.>>...........))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><<<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>.>>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>....>>>>>>>>>..>>><....<<<....>>>......>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<....<<..>>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<<.....>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>. .(.......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((..(((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))...)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...((((((((....(((...((((((((.(.((((((......)))).)))..))))))))..)).)....))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((..(((.........)))..))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....((((..(((..(((((.((((.((...{{....))))))(((...((((((((((((((((.((.....)))))))))....)))))))))..)))(....(((....)))......))))))...)))...))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..((.((((..(((...((...(((((....)))))...))...)))))))...)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....))....(((((.....]..)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((.((((((((((((.(.........(((((..(((......((((((((....))))))))...)))............)))))).)))))))))))).)))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((...((((((...((.......))...))))))....))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(.(((((.....(....)....))))).).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))...(((.....))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...)))).....). 70S Ribosome translocation intermediate FA-4.2A containing elongation factor EFG/FUSIDIC ACID/GDP, mRNA, and tRNA bound in the pe*/E state.; 23S ribosomal RNA 4v9m BB 119 4.0 RF00001 URS000080DE2B_262724 23812722 0003735 0005840 262724 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).)))))))))) 70S Ribosome translocation intermediate FA-4.2A containing elongation factor EFG/FUSIDIC ACID/GDP, mRNA, and tRNA bound in the pe*/E state.; 5S ribosomal RNA 4v9m CA 1511 4.0 RF00177,RF01959,RF01960 URS000080DFCE_262724 23812722 0003735 0005840 262724 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgaggaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucaccuc ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<...<..<<<.<<<..<<<..<<.<<<<<<<<<<.....>>>>>>>>>>.>>>>>......<<..<....<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>....<<<<.<<<<<....>>>>>.>>>>...<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>>>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>...>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<.<<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<....<<<......>>>.......>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>...<<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..>.......<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<......>>>..>>>>>>>>.<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>.......... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(.((.(((((.....))))).)).).)))))......(((......(((.((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..)))))).)))(((....(((..((((((((.......)))))))))))......)))..(((((((......)))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((.(((((......((........))..........(((((((......((((((((..((((((......))))))...((((....))))..))))))))..((.(((...((((((......(((((((((....)))...(((......)))...)))))).....((((.(((((((..((...(((.....)))).)...)))))))..(..(((((....))))).....)..)))).......).)))...)).)))))....)))))))..[)).))).)))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}......... 70S Ribosome translocation intermediate FA-4.2A containing elongation factor EFG/FUSIDIC ACID/GDP, mRNA, and tRNA bound in the pe*/E state.; ribosomal RNA 16S 4v9m CW 77 4.0 RF00005 URS0000093D11_562 23812722 0030533 0006412 562 ggcuacguagcucaguugguuagagcacaucacucauaaugauggggucacagguucgaaucccgucguagccacca <<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<.<<.......>>.>>>>>>>>>.... .((((((..(((...........))).(((((.......))))).....((.((.......)).))))))))..... 70S Ribosome translocation intermediate FA-4.2A containing elongation factor EFG/FUSIDIC ACID/GDP, mRNA, and tRNA bound in the pe*/E state.; transfer RNA 4v9m CV 23 4.0 23812722 262724 aaggagguaaaaaugguaaaaaa ....................... ....................... 70S Ribosome translocation intermediate FA-4.2A containing elongation factor EFG/FUSIDIC ACID/GDP, mRNA, and tRNA bound in the pe*/E state.; messenger RNA 4v9m DA 2879 4.0 RF02540,RF02541,RF00002 URS000080DEC7_262724 23812722 0003735 0005840 262724 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgucuaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaaaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagcuccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagacuacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu .<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.....>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..<<<<.......>>>>..>>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><<<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>.>>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>....>>>>>>>>>..>>><....<<<....>>>......>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>......<<<<........>>>>...<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<.<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>..>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<<.....>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>. .(.......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((..(((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))...)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.....(((((((((...(((...(((.((((.(.((((((......)))).)))..)))).)))..)).)...))))))))).....))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((..(((.........)))..))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(((((((...(((.......((((.(((....)))))))....)))..))))).)).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.((...{{....))))))(((...((((((((((((((((.((.....)))))))))....)))))))))..)))(....(((....)))......))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...((((.((.....(((....))).......)).)))).}((((.(((..(((((((..((....((...(((((....)))))...))....)))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....))....(((((.....]..)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........(((((..(((......((((((((....))))))))...)))............)))))).))))))))))))))))...(((.(....).)))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(.(((...((((((...((.......))...))))))....)))...)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))...(((.....))).....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...)))).....). 70S Ribosome translocation intermediate FA-4.2A containing elongation factor EFG/FUSIDIC ACID/GDP, mRNA, and tRNA bound in the pe*/E state.; 23S ribosomal RNA 4v9m DB 119 4.0 RF00001 URS000080DE2B_262724 23812722 0003735 0005840 262724 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<<....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>> .((((((((((....((((((((....(((((((.............))))..)))...)))))).))(((.......((.(((((....))))).)).......))).)))))))))) 70S Ribosome translocation intermediate FA-4.2A containing elongation factor EFG/FUSIDIC ACID/GDP, mRNA, and tRNA bound in the pe*/E state.; 5S ribosomal RNA 4v9n AA 1504 3.4 RF00177,RF01959,RF01960 URS000080E1FC_262724 23769667 0003735 0005840 262724 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgaggaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<.......>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<<....>>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<...<<...<<<.....>>>.>>....>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((.........)))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((.......)).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((.(.....).)).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((.(.....).)))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((.(..((((((((((......((........))..........(((((((..(...(..(((((..((((((......))))))...((((....))))..)))))..)).((.(((...((((((.(....((((((..(....).....(((......)))...)))))).....((((.((((((...(....(((.....)))..)....))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(.(..((..((.(....).))..))....).).....)))))))......(....(((((((........)))))))....)..)..).))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Crystal structure of the 70S ribosome bound with the Q253P mutant of release factor RF2.; 16S rRNA (1504-MER) 4v9n AV 10 3.4 23769667 262724 aauguaaaaa .......... .......... Crystal structure of the 70S ribosome bound with the Q253P mutant of release factor RF2.; messenger RNA (5'-R(*AP*AP*UP*GP*UP*AP*G)-3') 4v9n AW 77 3.4 RF00005 URS000041AF00_262724 23769667 0030533 0006412 262724 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the 70S ribosome bound with the Q253P mutant of release factor RF2.; P-site tRNA-fMet 4v9n BA 2789 3.4 RF02540,RF02541,RF00002 URS000080DD88_262724 23769667 0003735 0005840 262724 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggcaaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgucuaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaaaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagcuccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagacuacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.....>>>>>>.>>....<<<<<.....<<....>>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..<<<<.......>>>>..>>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>....>>>>>>>>>..>>>....<<<<....>>>>......>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<..>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<<.....>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((((((.......)))))))....(.(((((((((....(.(...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..).))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((.(.((((((......)))).)))..))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((((((........(((((...(..(((.........)))..).......(..............).)))))....))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))....((((........)))).]](((((((((((((...((((....(((((.(((..(((((.((((.((...{{....))))))(((...((((((((((((((((.((.....)))))))))....)))))))))..)))(...(((......))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((..))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....((((((..((..]]]]..)).)))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))...(((.....))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the 70S ribosome bound with the Q253P mutant of release factor RF2.; 23S ribosomal RNA 4v9n BB 119 3.4 RF00001 URS000080DE2B_262724 23769667 0003735 0005840 262724 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<.....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>..>>>>>>>>> .((((((((((....((((((((....(((.(((...(.....)...)))...)))...)))))).))(((.......((.(((((....))))).)).......))).)))))))))) Crystal structure of the 70S ribosome bound with the Q253P mutant of release factor RF2.; 5S ribosomal RNA 4v9n CA 1504 3.4 RF00177,RF01959,RF01960 URS000080E1FC_262724 23769667 0003735 0005840 262724 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgaggaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<.......>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<<....>>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<...<<...<<<.....>>>.>>....>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((.........)))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((.......)).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((.(.....).)).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((.(.....).)))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((.(..((((((((((......((........))..........(((((((..(...(..(((((..((((((......))))))...((((....))))..)))))..)).((.(((...((((((.(....((((((..(....).....(((......)))...)))))).....((((.((((((...(....(((.....)))..)....))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(.(..((..((.(....).))..))....).).....)))))))......(....(((((((........)))))))....)..)..).))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Crystal structure of the 70S ribosome bound with the Q253P mutant of release factor RF2.; 16S rRNA (1504-MER) 4v9n CV 10 3.4 23769667 262724 aauguaaaaa .......... .......... Crystal structure of the 70S ribosome bound with the Q253P mutant of release factor RF2.; messenger RNA (5'-R(*AP*AP*UP*GP*UP*AP*G)-3') 4v9n CW 77 3.4 RF00005 URS000041AF00_262724 23769667 0030533 0006412 262724 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the 70S ribosome bound with the Q253P mutant of release factor RF2.; P-site tRNA-fMet 4v9n DA 2789 3.4 RF02540,RF02541,RF00002 URS000080DD88_262724 23769667 0003735 0005840 262724 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggcaaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgucuaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaaaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagcuccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagacuacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.....>>>>>>.>>....<<<<<.....<<....>>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..<<<<.......>>>>..>>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>....>>>>>>>>>..>>>....<<<<....>>>>......>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<..>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<<.....>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((((((.......)))))))....(.(((((((((....(.(...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..).))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((.(.((((((......)))).)))..))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((((((........(((((...(..(((.........)))..).......(..............).)))))....))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))....((((........)))).]](((((((((((((...((((....(((((.(((..(((((.((((.((...{{....))))))(((...((((((((((((((((.((.....)))))))))....)))))))))..)))(...(((......))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((..))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....((((((..((..]]]]..)).)))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))...(((.....))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the 70S ribosome bound with the Q253P mutant of release factor RF2.; 23S ribosomal RNA 4v9n DB 119 3.4 RF00001 URS000080DE2B_262724 23769667 0003735 0005840 262724 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<.....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>..>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).)))))))))) Crystal structure of the 70S ribosome bound with the Q253P mutant of release factor RF2.; 5S ribosomal RNA 4v9o AB 118 2.9 RF00001 URS0000049E57_83333 23812721 0003735 0005840 83333 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))). Control of ribosomal subunit rotation by elongation factor G; 5S rRNA 4v9o AA 2854 2.9 RF02540,RF02541 URS00004B0F34_83333 23812721 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauggaaguguggacgccagucugcauggcuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<.....>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>.>......>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.......................................>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((((((.)))).))...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..((((......))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((((.(.............................................).))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Control of ribosomal subunit rotation by elongation factor G; 23S rRNA 4v9o BA 1533 2.9 RF00177,RF01959,RF01960 URS00000ABFE9_83333 23812721 0003735 0005840 83333 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggauca .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<..<<<......>>>..>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<.<.......>.>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<..<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>.........>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((...................)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..(......))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(...(((((((..........).))))).)...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))...(......)..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((...((.....)).))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Control of ribosomal subunit rotation by elongation factor G; 16S rRNA 4v9o CB 118 2.9 RF00001 URS0000049E57_83333 23812721 0003735 0005840 83333 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))). Control of ribosomal subunit rotation by elongation factor G; 5S rRNA 4v9o CA 2854 2.9 RF02540,RF02541 URS00004B0F34_83333 23812721 0003735 0005840 83333 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Control of ribosomal subunit rotation by elongation factor G; 23S rRNA 4v9o EB 118 2.9 RF00001 URS0000049E57_83333 23812721 0003735 0005840 83333 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))). Control of ribosomal subunit rotation by elongation factor G; 5S rRNA 4v9o FA 1533 2.9 RF00177,RF01959,RF01960 URS00000ABFE9_83333 23812721 0003735 0005840 83333 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggauca .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<......>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>...<.<<<<<......<.<<<<<<.<.......>.>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<<..>>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((.(.(..........).)..)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..(......))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(..(.(((((..(.......)..))))).)...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))...((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Control of ribosomal subunit rotation by elongation factor G; 16S rRNA 4v9o GB 118 2.9 RF00001 URS0000049E57_83333 23812721 0003735 0005840 83333 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca .<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<........<<<<<<<...>>>>>>>........>>...>>>>>>>>.. ..(((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((........(((((((...)))))))........))...)))))))... Control of ribosomal subunit rotation by elongation factor G; 5S rRNA 4v9o GA 2854 2.9 RF02540,RF02541 URS00004B0F34_83333 23812721 0003735 0005840 83333 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Control of ribosomal subunit rotation by elongation factor G; 16S rRNA 4v9p AA 2854 2.9 RF02540,RF02541 URS00004B0F34_83333 23812721 0003735 0005840 83333 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Control of ribosomal subunit rotation by elongation factor G; 23S rRNA 4v9p AB 118 2.9 RF00001 URS0000049E57_83333 23812721 0003735 0005840 83333 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. ..(((((((.....((((((((....(((.(((...(.....)...)))...)))...)))))).)).((.......((((((((...)))))))).......))...)))))))... 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Control of ribosomal subunit rotation by elongation factor G; 16S rRNA 4v9p CA 2854 2.9 RF02540,RF02541 URS00004B0F34_83333 23812721 0003735 0005840 83333 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Control of ribosomal subunit rotation by elongation factor G; 23S rRNA 4v9p CB 118 2.9 RF00001 URS0000049E57_83333 23812721 0003735 0005840 83333 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))). Control of ribosomal subunit rotation by elongation factor G; 5S rRNA 4v9p DA 1533 2.9 RF00177,RF01959,RF01960 URS00000ABFE9_83333 23812721 0003735 0005840 83333 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggauca .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<.<............>.>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<.<.......>.>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<..<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>.........>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((..............)).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..(((((((......)))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((.(.......)).))))).....)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((.((((.....)))).)))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))...((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((...((.....)).))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..)).)))))..).))...)..)..(((((((((....)))))))))}..... Control of ribosomal subunit rotation by elongation factor G; 16S rRNA 4v9p EA 2854 2.9 RF02540,RF02541 URS00004B0F34_83333 23812721 0003735 0005840 83333 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Control of ribosomal subunit rotation by elongation factor G; 23S rRNA 4v9p EB 118 2.9 RF00001 URS0000049E57_83333 23812721 0003735 0005840 83333 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))). 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Control of ribosomal subunit rotation by elongation factor G; 16S rRNA 4v9p GA 2854 2.9 RF02540,RF02541 URS00004B0F34_83333 23812721 0003735 0005840 83333 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Control of ribosomal subunit rotation by elongation factor G; 23S rRNA 4v9p GB 118 2.9 RF00001 URS0000049E57_83333 23812721 0003735 0005840 83333 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. ..(((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))... Control of ribosomal subunit rotation by elongation factor G; 5S rRNA 4v9p HA 1533 2.9 RF00177,RF01959,RF01960 URS00000ABFE9_83333 23812721 0003735 0005840 83333 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggauca .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<............>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<.<.......>.>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<...>>...>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<<..<<<.....>>>>>.....>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((.((............))..)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....(((((..(.......)..))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((..(...(((((........))))).............)...).))).((.(((...((((((.(....(((((((((....)))....((......))....)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..(..(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..)..)...)..)..(((((((((....)))))))))}..... Control of ribosomal subunit rotation by elongation factor G; 16S rRNA 4v9q AA 2832 3.4 RF02540,RF02541,RF00002 URS000080DD88_262724 23824292 0003735 0005840 262724 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggcaaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgucuaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaaaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagcuccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagacuacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu .<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.....>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<........>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<.........>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>....>>>>>>>>>..>>>....<<<<....>>>>......>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<.......<<<<<<<<....>>>>>>>>....>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<<.....>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>. (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((.(.(..(.(......).)...))..)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((........(.......)....)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.((...{{....))))))(((...((((((((((((((((.((.....)))))))))....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........(((((............(((((((....)))))))...................)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))...(((.....))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal Structure of Blasticidin S Bound to Thermus Thermophilus 70S Ribosome.; 23S ribosomal RNA 4v9q AB 119 3.4 RF00001 URS000080DE2B_262724 23824292 0003735 0005840 262724 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<<....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).)))))))))) Crystal Structure of Blasticidin S Bound to Thermus Thermophilus 70S Ribosome.; 5S ribosomal RNA 4v9q BA 1504 3.4 RF00177,RF01959,RF01960 URS000080E1FC_262724 23824292 0003735 0005840 262724 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgaggaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<.......>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<........<<........>>..........<<<<<<<.......<<<<<<<..<<<<<<<....>>>>>>>...<<<......>>>..>>>>>>>..<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>......>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<<..>>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.....)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((.(....).)))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((.(..((((((((((......((........))..........(((((((..(...((((((((..(((((((....)))))))...((((....))))..))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...(...(((.....)))).....)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..).))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Crystal Structure of Blasticidin S Bound to Thermus Thermophilus 70S Ribosome.; 16S ribosomal RNA 4v9q BV 77 3.4 RF00005 URS000041AF00_512 23824292 0030533 0006412 512 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal Structure of Blasticidin S Bound to Thermus Thermophilus 70S Ribosome.; tRNA 4v9q BW 77 3.4 RF00005 URS000041AF00_512 23824292 0030533 0006412 512 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal Structure of Blasticidin S Bound to Thermus Thermophilus 70S Ribosome.; tRNA 4v9q CA 2832 3.4 RF02540,RF02541,RF00002 URS000080DD88_262724 23824292 0003735 0005840 262724 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggcaaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgucuaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaaaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagcuccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagacuacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu .<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.....>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<........>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<.........>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>....>>>>>>>>>..>>>....<<<<....>>>>......>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<.......<<<<<<<<....>>>>>>>>....>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<<.....>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>. (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((.(.(..(.(......).)...))..)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((........(.......)....)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.((...{{....))))))(((...((((((((((((((((.((.....)))))))))....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........(((((............(((((((....)))))))...................)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))...(((.....))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal Structure of Blasticidin S Bound to Thermus Thermophilus 70S Ribosome.; 23S ribosomal RNA 4v9q CB 119 3.4 RF00001 URS000080DE2B_262724 23824292 0003735 0005840 262724 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<<....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).)))))))))) Crystal Structure of Blasticidin S Bound to Thermus Thermophilus 70S Ribosome.; 5S ribosomal RNA 4v9q DA 1504 3.4 RF00177,RF01959,RF01960 URS000080E1FC_262724 23824292 0003735 0005840 262724 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgaggaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<.......>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<........<<........>>..........<<<<<<<.......<<<<<<<..<<<<<<<....>>>>>>>...<<<......>>>..>>>>>>>..<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>......>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<<..>>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.....)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((.(....).)))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((.(..((((((((((......((........))..........(((((((..(...((((((((..(((((((....)))))))...((((....))))..))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...(...(((.....)))).....)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..).))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Crystal Structure of Blasticidin S Bound to Thermus Thermophilus 70S Ribosome.; 16S ribosomal RNA 4v9q DV 77 3.4 RF00005 URS000041AF00_512 23824292 0030533 0006412 512 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal Structure of Blasticidin S Bound to Thermus Thermophilus 70S Ribosome.; tRNA 4v9q DW 77 3.4 RF00005 URS000041AF00_512 23824292 0030533 0006412 512 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal Structure of Blasticidin S Bound to Thermus Thermophilus 70S Ribosome.; tRNA 4v9r AA 1498 3.0 RF00177,RF01959,RF01960 URS000080E226_274 24412368 0003735 0005840 274 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccucgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggau .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<...>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>....<<......>>...>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((..)))))))).)))))......(((......((((((((..((...(((((((.(((((......((((....)))).......)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((.......))...)))))).).....(.(((...(.(((....)))..))))).)).))))))..((((......((((....)))).....))))....(((((...(.....(((.....)))......)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((......(((((((...(((.(((....))).)))....((......))....)))))))..((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}... Crystal structure of antibiotic DITYROMYCIN bound to 70S ribosome; 16S Ribosomal RNA 4v9r AX 76 3.0 RF00005 URS000041AF00_562 24412368 0030533 0006412 562 gcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of antibiotic DITYROMYCIN bound to 70S ribosome; P-site tRNA 4v9r BA 2731 3.0 RF02540,RF02541,RF00002 URS00001698E8_274 24412368 0003735 0005840 274 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagcggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuugugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<....<<<<........>>>.>....>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<...>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<..>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((...((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((.(...((.(......).))...)..))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.........)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((..)))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..(((...)))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of antibiotic DITYROMYCIN bound to 70S ribosome; 23S Ribosomal RNA 4v9r BB 120 3.0 RF00001 URS00005F2F4B_274 24412368 0003735 0005840 274 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of antibiotic DITYROMYCIN bound to 70S ribosome; 5S Ribosomal RNA 4v9r CA 1503 3.0 RF00177,RF01959,RF01960 URS000080E226_274 24412368 0003735 0005840 274 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggau .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>....<<.....>>....>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......(((......))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((.(((((((...))))))).))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((.(((((..(.(((((....))))).)......(....).....))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(.(((((..(((..(((.....))))))...))))).)..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}... Crystal structure of antibiotic DITYROMYCIN bound to 70S ribosome; 16S Ribosomal RNA 4v9r CX 76 3.0 RF00005 URS000041AF00_562 24412368 0030533 0006412 562 gcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of antibiotic DITYROMYCIN bound to 70S ribosome; P-site tRNA 4v9r DA 2714 3.0 RF02540,RF02541,RF00002 URS00001698E8_274 24412368 0003735 0005840 274 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<..>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<..>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<..>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((()))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((.(..(.(((......)))..).)..))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((((((()))))))))).))..........]]].)....))))))))))...)))))))(((((((())))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((.((((((..((.....)).))))))......))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((..))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))((((.))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal structure of antibiotic DITYROMYCIN bound to 70S ribosome; 23S Ribosomal RNA 4v9r DB 120 3.0 RF00001 URS00005F2F4B_274 24412368 0003735 0005840 274 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>. .((((((((((....((((((.(....(((((((...(.....)...))))..)))...).)))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of antibiotic DITYROMYCIN bound to 70S ribosome; 5S Ribosomal RNA 4v9s AA 1498 3.1 RF00177,RF01959,RF01960 URS000080E226_300852 24412368 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccucgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggau .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<...>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>....<<......>>...>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((())))))))).)))))......(((......((((((((..((...(((((((.(((((....(.((((....)))).).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((.......))...)))))).).....(.(((...(.(((....)))..))))).)).))))))..((((......((((....)))).....))))....(((((...(.....(((.....)))......)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((......(((((((...(((.(((....))).)))....(((....)))....)))))))..((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}... Crystal structure of antibiotic GE82832 bound to 70S ribosome; 16S Ribosomal RNA 4v9s AX 76 3.1 RF00005 URS000041AF00_562 24412368 0030533 0006412 562 gcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of antibiotic GE82832 bound to 70S ribosome; P-site tRNA 4v9s BA 2731 3.1 RF02540,RF02541,RF00002 URS00001698E8_300852 24412368 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagcggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuugugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<........>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<...>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<..>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((...((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((.(...((..........))...)..))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.........)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((..)))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..((((.))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of antibiotic GE82832 bound to 70S ribosome; 23S Ribosomal RNA 4v9s BB 120 3.1 RF00001 URS00005F2F4B_300852 24412368 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of antibiotic GE82832 bound to 70S ribosome; 5S Ribosomal RNA 4v9s CA 1503 3.1 RF00177,RF01959,RF01960 URS000080E226_300852 24412368 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggau .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>....<<.....>>....>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((.(((((((...))))))).))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((.((((...(.(((((....))))).)......(....)......)))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(.(((((..(((..(((.....))))))...))))).)..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}... Crystal structure of antibiotic GE82832 bound to 70S ribosome; 16S Ribosomal RNA 4v9s CX 76 3.1 RF00005 URS000041AF00_562 24412368 0030533 0006412 562 gcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of antibiotic GE82832 bound to 70S ribosome; P-site tRNA 4v9s DA 2714 3.1 RF02540,RF02541,RF00002 URS00001698E8_300852 24412368 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<..>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<..>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((()))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((.(..(.(((......)))..).)..)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((((((()))))))))).))..........]]].)....))))))))))...)))))))(((((((())))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((.((((((..((.....)).))))))......))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((..))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(((...)).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal structure of antibiotic GE82832 bound to 70S ribosome; 23S Ribosomal RNA 4v9s DB 120 3.1 RF00001 URS00005F2F4B_300852 24412368 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>. .((((((((((....((((((.(....(((((((...(.....)...))))..)))...).)))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of antibiotic GE82832 bound to 70S ribosome; 5S Ribosomal RNA 4w29 AA 1511 3.8 RF00177,RF01959,RF01960 URS000080DFCE_262724 25190797 0003735 0005840 262724 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgaggaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucaccuc ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<...<..<<<.<<<..<<<..<<.<<<<<<<<<<.....>>>>>>>>>>.>>>>>......<<..<....<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>....<<<<.<<<<<....>>>>>.>>>>...<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>>>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>...>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<.<<<<<<<<<.<......<<<<<<.....>>>>>>....>.>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<....<<<......>>>.......>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>...<<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..>.......<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<.....<<<<<....>>>>>...>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<.<<......<<........>>..........<<<<<<<.......<<<<<<...<<<<<<<....>>>>>>>...<<<......>>>...>>>>>>..<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>..>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<<..>>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>.......... ....((((..[.[[[..)))).((((.(((((..(((((((((.....((.(((..(((..((.((((((((((.....)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....((...((((((((.......)))))))).))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))..).......(((...(((((....)))).))))..)).))))))..((((.......(((....)))......))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.(((....(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((.(....((((((....((........)).......))))))....).......((....))..))))))..))))).)))..))))....)))....((((((...((...((((.........))))...))))))))......{...((((((..((((.(((((...))))).))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((....((((.(((((......((........))..........(((((((......((((((((..(((((((....)))))))...((((....))))..))))))))..((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...(...(((.....)))).....)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).))).)))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)....))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((.((((((...(.((((....(((....))).)))).)..)))))).))))))..))).))))..).))...)..)..(((((((((....)))))))))}......... 70S ribosome translocation intermediate containing elongation factor EFG/GDP/fusidic acid, mRNA, and tRNAs trapped in the AP/AP pe/E chimeric hybrid state.; 16S Ribosomal RNA 4w29 AW 77 3.8 RF00005 URS0000093D11_562 25190797 0030533 0006412 562 ggcuacguagcucaguugguuagagcacaucacucauaaugauggggucacagguucgaaucccgucguagccacca .<<<<<<..<<<...........>>>.<<<<<.......>>>>>......<.<<.......>>.>.>>>>>>..... .((((((..(((...........))).(((((.......)))))........((.......))...))))))..... 70S ribosome translocation intermediate containing elongation factor EFG/GDP/fusidic acid, mRNA, and tRNAs trapped in the AP/AP pe/E chimeric hybrid state.; tRNA 4w29 AV 36 3.8 25190797 511145 ggcaaggagguaaaaaugguauacaaaaaaaucaaa .................................... .................................... 70S ribosome translocation intermediate containing elongation factor EFG/GDP/fusidic acid, mRNA, and tRNAs trapped in the AP/AP pe/E chimeric hybrid state.; mRNA 4w29 AX 78 3.8 RF00005 URS000080E345_562 25190797 0030533 0006412 562 gggugauuagcucagcugggagagcaccucccuuacaaggagggggucggcgguucgaucccgucaucacccaccaVn .<<<<<<..<<<<........>>>>.<<<<<.......>>>>>......................>>>>>>....... (((((((..((((........)))).(((((.......))))).....(...............)))))))).... 70S ribosome translocation intermediate containing elongation factor EFG/GDP/fusidic acid, mRNA, and tRNAs trapped in the AP/AP pe/E chimeric hybrid state.; tRNA 4w29 BA 2879 3.8 RF02540,RF02541,RF00002 URS000080DEC7_262724 25190797 0003735 0005840 262724 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgucuaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaaaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagcuccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagacuacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu .<<......<<<<<<<<<<<.....((..((<<<<<<((<<......<<<<<<.((..((.>>>.....<<<<<<<..<<.))..))..>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.....>>>>>>.>>....<<<<<.....<......>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..<<<<>>>>>..>>>......)).>>>>>>.))...............<<....>>....)).........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<.<<<<...<<<<<<......>>>>.>>...>>>>.>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<............>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<......<.<<<<<.<<<..<<<<.......>>>>..>>>.........<<......>>...>>>>>.>..>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..((((...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>....>>>>>>>>>..>>><....<<<....>>>......>>>>>>...>>>..>>>>>.........>>>.>..>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.[[.<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<......>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<.......>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>...]]>>>>.......<<<<..<<<<<<<...<<.......>>...>>>>>>>...>>>.>.........<<<...<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<.......>>>>.....>>>>.......>>>.......<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<.)))).>>>>>...>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>...<<<.....>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>. (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.....)))))).))...((((((.....(...[..)......))))).).........((....))...((((......((.]...)).....))))...(((....((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).))).....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..(.((.....)).).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...((((((((....(((...((((((((...((.(((......)))..))...))))))))..)).)....))))))))..)..))))))).))..((.((((............)))).)).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((..(((.........)))..))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((....((......(((((.(((....))))))))...))...)))))..).....))))))(......((.....((((((.......))))))((((....((((..((.([((((((...((.....)).)))))))...[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.((...{{....))))))(((...((((((((((((((((.((.....)))))))))....)))))))))..)))(....(((....)))......))))))...)))..)))))(..).....))))...))...))))))))))))))).])).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((((.......)))))))))))(...).......((((.((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(.(((.........))).)........((..........(((((.......)))))..)..)....))))...)).)).)))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((..(.((((((.(.........(((((..(((......(((((.((....)).)))))...)))............)))))).)))))).)..))))))...(((.(....).)))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....((.((((.((..]]]]..)))))).)).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(((((((....))).))))..>.)...)))))))))))[...((((((....((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..].....))))))...(((.....))).....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))....))) 70S ribosome translocation intermediate containing elongation factor EFG/GDP/fusidic acid, mRNA, and tRNAs trapped in the AP/AP pe/E chimeric hybrid state.; 23S Ribosomal RNA 4w29 BB 119 3.8 RF00001 URS000080DE2B_262724 25190797 0003735 0005840 262724 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg ...<<<<<<<<....<<.<<<<<....<<<<<<...............>>>..>>>...>>>>>..>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>.. .((((((..((....((((((......(((((((...(.....)...))))..))).....)))).))(((.......(..(((((....)))))..).......))).))..)))))) 70S ribosome translocation intermediate containing elongation factor EFG/GDP/fusidic acid, mRNA, and tRNAs trapped in the AP/AP pe/E chimeric hybrid state.; 5S Ribosomal RNA 4w29 CA 1511 3.8 RF00177,RF01959,RF01960 URS000080DFCE_262724 25190797 0003735 0005840 262724 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgaggaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucaccuc ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<<.....>>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>....<<<<.<<<<<....>>>>>.>>>>...<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<...<<<<<<<.......>>>>>>>.>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<.<......<<<<<..>>>>>.....>.>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<..))).>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<....<<<......>>>.......>>>>>>.>..........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<.......<<<<<<...<<<<<<<....>>>>>>>...<<<......>>>...>>>>>>..<<<.<<<..<<<<<<.......<<<<..<<<....>>>...<<<......>>>.....>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<...<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>...>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>.......... ....((((..[.[[[[.)))).((((.(((((..((((((.(.....(((.(((..(((..((.((((((((((.....)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(.(((....))).).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).........(((...(((((....)))).))))..)..))))))..((((.......(((....)))......))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((.(.(((((((.((......((((((.....))))))....)).)))))..))).)))))..((((((((....((((((.(....((((((....((........)).......))))))....).......((....))..))))))...)))).)))..))))...))))....((((((....(...((((.........))))...).))))))......{...((((((..((((.(.(((...))).).))))...((..]])).....)))))))))).(.(......((((....))))....).)..]]]].]((((..(((((((.((..(((((..((((.(((((......((........))..........(((((((..(...((((((((..(((((((....)))))))...((((....))))..))))))))).((.(((...((((((......((((.((((....)))...(((......)))...).)))).....((((.(((((((..((...(((.....)))).)...)))))))..(..(((((....))))).....)..)))).......).)))...)).)))))....)))))))..[)).))).)))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))...........(((((((........))))))).......)..))))).....(((((((......]...)))))))......))...))))))).)).))..(....((...((((.(((..((((((.((((((...(.((((....(((....))).)))).)..)))))).))))))..))).))))....))......)..(((.(((((....))))).)))}......... 70S ribosome translocation intermediate containing elongation factor EFG/GDP/fusidic acid, mRNA, and tRNAs trapped in the AP/AP pe/E chimeric hybrid state.; 16S Ribosomal RNA 4w29 CV 36 3.8 25190797 511145 ggcaaggagguaaaaaugguauacaaaaaaaucaaa .................................... .................................... 70S ribosome translocation intermediate containing elongation factor EFG/GDP/fusidic acid, mRNA, and tRNAs trapped in the AP/AP pe/E chimeric hybrid state.; mRNA 4w29 CW 77 3.8 RF00005 URS0000093D11_562 25190797 0030533 0006412 562 ggcuacguagcucaguugguuagagcacaucacucauaaugauggggucacagguucgaaucccgucguagccacca .<<<<<<..<<<...........>>>.<<<<<.......>>>>>......<.<<.......>>.>.>>>>>>..... .((((((..(((...........))).(((((.......)))))........((.......))...))))))..... 70S ribosome translocation intermediate containing elongation factor EFG/GDP/fusidic acid, mRNA, and tRNAs trapped in the AP/AP pe/E chimeric hybrid state.; tRNA 4w29 CX 78 3.8 RF00005 URS000080E345_562 25190797 0030533 0006412 562 gggugauuagcucagcugggagagcaccucccuuacaaggagggggucggcgguucgaucccgucaucacccaccaVn <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>......<<<<.......>>>>.>>>>>>>...... .((((((..((((........)))).(((((.......))))).......(((.......)))..))))))..... 70S ribosome translocation intermediate containing elongation factor EFG/GDP/fusidic acid, mRNA, and tRNAs trapped in the AP/AP pe/E chimeric hybrid state.; tRNA 4w29 DA 2879 3.8 RF02540,RF02541,RF00002 URS000080DEC7_262724 25190797 0003735 0005840 262724 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgucuaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaaaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagcuccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagacuacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu .<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.....>>>>>>.>>....<<<<<.....<......>......>>>>>.....<.....<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<....<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>..>>>>...>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>....>.>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.......>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<..<<<<...<<<<<<......>>>>.>>...>>>>..>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<((......<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>...........))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>....>>>>>>>>>..>>><....<<<....>>>......>>>>>>...>>>...>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<....<<..>>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>....................<<<<<<.....>>>>>>..........>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<..<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>.....>>>>.>>>..>>>>>..<<<.......>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.........<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<.......>>>>.....>>>>>..>...>>>.......<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<<.....>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>. .(........(((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...(((....(((.((((.....)))).)))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).))).....((((((((..[......))))))))....)..((((].[[[[))))...)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))......(.((((((.((((....)))).))))))...(.(........).).((((((....((((((((.((((..(((...(((.....)))...)))...((....))..(.((.....)).).....)))).))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.....((((((((....(((...((((((((.(.((((((......)))).)))..))))))))..)).)....)))))))).....))))))).))..((.((((.((......)).)))).)).....(((......)))...((((.(((...((([[[.....((((((.....(.....((..((((((((((.....{..(((..(((..(((.........)))..))).....(...((......)).)..)))....)))))))))).))..........]]].)....)))))).)))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.((...{{....))))))(((...((((((((.(((((((.((.....))))))))).....))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).((((......))))..))))..((((....((((((((.((..(............(((((......{........)))))(((((((((((.......)))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(.(((.........))).)........((..........(((((.......)))))..)..)....))))...)).)))))))....))).)))))))).)))))).....))....(((((........)))))..((((((((.(((..(......((((.((((((..(((((.(((.((.((.(((((.((((((((((.(.........(((((..(((......(((((.((....)).)))))...)))............)))))).)))))))))).)))))...(((((....)))))....)).)).)))..)))))..(((.......)))((((((...........))))))([((...(((((((.(.(((((.........)))))...).((]..[[[))....)))))))...((((..(((......)))..)))).(((....))).))]]].......((.((((.((..]]]]..)))))).)).....).......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...(((....(((((((((((.}}.))))))...)))))....))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))...(((.....))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...)))).....). 70S ribosome translocation intermediate containing elongation factor EFG/GDP/fusidic acid, mRNA, and tRNAs trapped in the AP/AP pe/E chimeric hybrid state.; 23S Ribosomal RNA 4w29 DB 119 3.8 RF00001 URS000080DE2B_262724 25190797 0003735 0005840 262724 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<......>>>>>>>.......>>>.>>>>>>>>>> .((((((.(((....((((((......(((((((...(.....)...))))..))).....)))).))(((.......((.(((........))).)).......))).))).)))))) 70S ribosome translocation intermediate containing elongation factor EFG/GDP/fusidic acid, mRNA, and tRNAs trapped in the AP/AP pe/E chimeric hybrid state.; 5S Ribosomal RNA 4w2e A 2873 2.9 RF02540,RF02541,RF00002 URS00001698E8_274 25104389 0003735 0005840 274 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgagucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<...>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<...>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>...>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((..(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((...))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((.(.((((((......)))).)))..)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((((.((.....{..(.........(((.........)))..........(...((......)).)....)....)).))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((.(((((((.((.....)))))))))......))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........(((((..(((......((((((((....))))))))...)))............)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(..(((.))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))..)))) Crystal structure of Elongation Factor 4 (EF4/LepA) bound to the Thermus thermophilus 70S ribosome; 23S Ribosomal RNA 4w2e B 120 2.9 RF00001 URS00005F2F4B_274 25104389 0003735 0005840 274 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>. .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of Elongation Factor 4 (EF4/LepA) bound to the Thermus thermophilus 70S ribosome; 5S Ribosomal RNA 4w2e x 74 2.9 RF00005 URS00005AA258_562 25104389 0030533 0006412 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[..)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of Elongation Factor 4 (EF4/LepA) bound to the Thermus thermophilus 70S ribosome; E-site tRNA 4w2e a 1496 2.9 RF00177,RF01959,RF01960 URS000080DFED_274 25104389 0003735 0005840 274 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcggucguaacaagguagcuguaccggaaggugcggcugga .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<....>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>.<.<.<......>.>.>>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>>.>>...>.....<<<<<<<<<....>>>>>>>>>... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((((((.().))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((((((....))))))).(.(.(.......)).).)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..((...(((.....)))).)...))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))).))...)..)..(((((((((....)))))))))}.. Crystal structure of Elongation Factor 4 (EF4/LepA) bound to the Thermus thermophilus 70S ribosome; 16S Ribosomal RNA 4w2e w 76 2.9 RF00005 URS00005AA258_562 25104389 0030533 0006412 562 gcccgganagcucagucgguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of Elongation Factor 4 (EF4/LepA) bound to the Thermus thermophilus 70S ribosome; E-site tRNA 4w2f AA 1497 2.4 RF00177,RF01959,RF01960 URS000080DFED_300852 25306919 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccugggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggau .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<..>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>....<<......>>...>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((((((.().))))))).)))))......(((......((((((((..((...(((((((.(((((....(.((((....)))).).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((..))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...((..(((....)))..))....(((....)))....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}... Crystal structure of the Thermus thermophilus 70S ribosome in complex with amicoumacin, mRNA and three deacylated tRNAs in the A, P and E sites; 16S Ribosomal RNA 4w2f AV 13 2.4 25306919 32630 aaaaauguucuaa ............. ............. Crystal structure of the Thermus thermophilus 70S ribosome in complex with amicoumacin, mRNA and three deacylated tRNAs in the A, P and E sites; mRNA 4w2f AW 74 2.4 RF00005 URS00005AA258_562 25306919 0030533 0006412 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[..)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with amicoumacin, mRNA and three deacylated tRNAs in the A, P and E sites; A/P-site tRNA 4w2f AX 76 2.4 RF00005 URS000041AF00_562 25306919 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with amicoumacin, mRNA and three deacylated tRNAs in the A, P and E sites; E-site tRNA 4w2f AY 74 2.4 RF00005 URS00005AA258_562 25306919 0030533 0006412 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((......)))).((((.........)))).....(.(((.......))).)))))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with amicoumacin, mRNA and three deacylated tRNAs in the A, P and E sites; A/P-site tRNA 4w2f BA 2871 2.4 RF02540,RF02541,RF00002 URS00001698E8_300852 25306919 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>....<<<<<.....<<....>>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<.....<<<........>>>......>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<.<<<<.......>>>>..>>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<.<......>.>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((..(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((......(((......))).......))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{..((((.(((..................))).....(...(........).).))))....)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((.(((((((((.(......[..(((((..(((......((((((((....))))))))...)))..........].)))))).))))))))).))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..((((.))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with amicoumacin, mRNA and three deacylated tRNAs in the A, P and E sites; 23S Ribosomal RNA 4w2f BB 120 2.4 RF00001 URS000080DEE8_300852 25306919 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the Thermus thermophilus 70S ribosome in complex with amicoumacin, mRNA and three deacylated tRNAs in the A, P and E sites; 5S Ribosomal RNA 4w2f CA 1503 2.4 RF00177,RF01959,RF01960 URS000080DFED_300852 25306919 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggau .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>....<<.....>>....>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((.(....).)))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...((((((......)))))).(....(....)....).)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}... Crystal structure of the Thermus thermophilus 70S ribosome in complex with amicoumacin, mRNA and three deacylated tRNAs in the A, P and E sites; 16S Ribosomal RNA 4w2f CV 13 2.4 25306919 32630 aaaaauguucuaa ............. ............. Crystal structure of the Thermus thermophilus 70S ribosome in complex with amicoumacin, mRNA and three deacylated tRNAs in the A, P and E sites; mRNA 4w2f CW 72 2.4 RF00005 URS00005AA258_562 25306919 0030533 0006412 562 cccgganagcucagggagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<..<<<<.....>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((...[.)))).((((.........)))).....(((((..]....)))))))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with amicoumacin, mRNA and three deacylated tRNAs in the A, P and E sites; A/P-site tRNA 4w2f CX 76 2.4 RF00005 URS000041AF00_562 25306919 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with amicoumacin, mRNA and three deacylated tRNAs in the A, P and E sites; E-site tRNA 4w2f CY 73 2.4 RF00005 URS00005AA258_562 25306919 0030533 0006412 562 gcccgganagcucagggagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<.....>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....)))).((((.........)))).....((.((.......)).))))))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with amicoumacin, mRNA and three deacylated tRNAs in the A, P and E sites; A/P-site tRNA 4w2f DA 2800 2.4 RF02540,RF02541,RF00002 URS00001698E8_300852 25306919 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<........>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<..>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<.<<....>>.>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((()))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((....(.(..........)..)....))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((((((()))))))))).))..........]]].)....))))))))))...)))))))(((((((())))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........(((((..(((......(((((.((....)).)))))...)))............)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....))))))).((...)).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with amicoumacin, mRNA and three deacylated tRNAs in the A, P and E sites; 23S Ribosomal RNA 4w2f DB 120 2.4 RF00001 URS000080DEE8_300852 25306919 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>. .(((((((.((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)).))))))). Crystal structure of the Thermus thermophilus 70S ribosome in complex with amicoumacin, mRNA and three deacylated tRNAs in the A, P and E sites; 5S Ribosomal RNA 4w2g AA 1498 2.55 RF00177,RF01959,RF01960 URS000080DFED_300852 25306919 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccucgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggau .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<...>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>.....<......>....>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((..)))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((...))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((((((....)))))))....(((....)))....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}... Crystal structure of the Thermus thermophilus 70S ribosome in complex with pactamycin (soaked), mRNA and three deacylated tRNAs in the A, P and E sites; 16S Ribosomal RNA 4w2g AV 13 2.55 25306919 32630 aaaaauguucuaa ............. ............. Crystal structure of the Thermus thermophilus 70S ribosome in complex with pactamycin (soaked), mRNA and three deacylated tRNAs in the A, P and E sites; mRNA 4w2g AW 74 2.55 RF00005 URS00005AA258_562 25306919 0030533 0006412 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<......>>>><<<<<<<.....>>>>>>.>...<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[..)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with pactamycin (soaked), mRNA and three deacylated tRNAs in the A, P and E sites; A/P-site tRNA 4w2g AX 76 2.55 RF00005 URS000041AF00_562 25306919 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with pactamycin (soaked), mRNA and three deacylated tRNAs in the A, P and E sites; E-site tRNA 4w2g AY 74 2.55 RF00005 URS00005AA258_562 25306919 0030533 0006412 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((......)))).((((.........)))).....((.((.......)).))))))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with pactamycin (soaked), mRNA and three deacylated tRNAs in the A, P and E sites; A/P-site tRNA 4w2g BA 2819 2.55 RF02540,RF02541,RF00002 URS00001698E8_300852 25306919 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagcggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<....<<<<<......>>>>.>....>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<...>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<..<<....>>..>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((...((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((.....((((......))))......)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.........)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(......[..(((((..(((......((((.(((....))).))))...)))..........].)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..((((.))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with pactamycin (soaked), mRNA and three deacylated tRNAs in the A, P and E sites; 23S Ribosomal RNA 4w2g BB 120 2.55 RF00001 URS000080DEE8_300852 25306919 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the Thermus thermophilus 70S ribosome in complex with pactamycin (soaked), mRNA and three deacylated tRNAs in the A, P and E sites; 5S Ribosomal RNA 4w2g CA 1503 2.55 RF00177,RF01959,RF01960 URS000080DFED_300852 25306919 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggau .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>....<.......>....>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...((((((......))))))...(..(....)..)...)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}... Crystal structure of the Thermus thermophilus 70S ribosome in complex with pactamycin (soaked), mRNA and three deacylated tRNAs in the A, P and E sites; 16S Ribosomal RNA 4w2g CV 13 2.55 25306919 32630 aaaaauguucuaa ............. ............. Crystal structure of the Thermus thermophilus 70S ribosome in complex with pactamycin (soaked), mRNA and three deacylated tRNAs in the A, P and E sites; mRNA 4w2g CW 72 2.55 RF00005 URS00005AA258_562 25306919 0030533 0006412 562 cccgganagcucagggagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<..<<<<.....>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((...[.)))).((((.........)))).....(((((..]....)))))))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with pactamycin (soaked), mRNA and three deacylated tRNAs in the A, P and E sites; A/P-site tRNA 4w2g CX 76 2.55 RF00005 URS000041AF00_562 25306919 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with pactamycin (soaked), mRNA and three deacylated tRNAs in the A, P and E sites; E-site tRNA 4w2g CY 73 2.55 RF00005 URS00005AA258_562 25306919 0030533 0006412 562 gcccgganagcucagggagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<.....>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[.)))).((((.........)))).....((.((..]....)).))))))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with pactamycin (soaked), mRNA and three deacylated tRNAs in the A, P and E sites; A/P-site tRNA 4w2g DA 2800 2.55 RF02540,RF02541,RF00002 URS00001698E8_300852 25306919 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<....<<<<<......>>>>.>....>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<..>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<.<<....>>.>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....(())....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((.(..(((.(......).)).).)..)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((((((()))))))))).))..........]]].)....))))))))))...)))))))(((((((())))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........(((((..(((.......((((.((....)).))))....)))............)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....))))))).............(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))....))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with pactamycin (soaked), mRNA and three deacylated tRNAs in the A, P and E sites; 23S Ribosomal RNA 4w2g DB 120 2.55 RF00001 URS000080DEE8_300852 25306919 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>. .((((((((((....((((((.(....(((((((...(.....)...))))..)))...).)))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the Thermus thermophilus 70S ribosome in complex with pactamycin (soaked), mRNA and three deacylated tRNAs in the A, P and E sites; 5S Ribosomal RNA 4w2h AA 1497 2.7 RF00177,RF01959,RF01960 URS000080DFED_300852 25306919 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggau .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<...<<<<<<....>>>>>.>...>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<.....>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>....<<......>>...>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((..)))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((..)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((...(((((((....))))))).(..(((....)))..).)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}... Crystal structure of the Thermus thermophilus 70S ribosome in complex with pactamycin (co-crystallized), mRNA and deacylated tRNA in the P site; 16S Ribosomal RNA 4w2h AX 76 2.7 RF00005 URS000041AF00_562 25306919 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with pactamycin (co-crystallized), mRNA and deacylated tRNA in the P site; P-site tRNA 4w2h AY 18 2.7 RF00005 URS00005AA258_562 25306919 0030533 0006412 562 gcccggauccgggcacca <<<<<<..>>>>>>.... ((((((..)))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with pactamycin (co-crystallized), mRNA and deacylated tRNA in the P site; E-site tRNA Acceptor Stem 4w2h BA 2822 2.7 RF02540,RF02541,RF00002 URS00001698E8_300852 25306919 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagcggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgucgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<...>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<...>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<..<<....>>..>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((...((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((.......((......))........))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.........)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((...)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((.(((.((((((((.(......[..(((((..(((......((((..((....))..))))...)))..........].)))))).)))))))).))).)))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..(((...)))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with pactamycin (co-crystallized), mRNA and deacylated tRNA in the P site; 23S Ribosomal RNA 4w2h BB 120 2.7 RF00001 URS000080DEE8_300852 25306919 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>. .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the Thermus thermophilus 70S ribosome in complex with pactamycin (co-crystallized), mRNA and deacylated tRNA in the P site; 5S Ribosomal RNA 4w2h CA 1503 2.7 RF00177,RF01959,RF01960 URS000080DFED_300852 25306919 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggau .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<.......>.....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<..<.<<<<<<<........>>>>>>>>...>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>.... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(.(((((....))))).).....((....)).....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}... Crystal structure of the Thermus thermophilus 70S ribosome in complex with pactamycin (co-crystallized), mRNA and deacylated tRNA in the P site; 16S Ribosomal RNA 4w2h CX 76 2.7 RF00005 URS000041AF00_562 25306919 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with pactamycin (co-crystallized), mRNA and deacylated tRNA in the P site; P-site tRNA 4w2h DA 2800 2.7 RF02540,RF02541,RF00002 URS00001698E8_300852 25306919 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<..>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((()))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((......(((......))).......)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((.().)))))))).))..........]]].)....))))))))))...)))))))(((((((())))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........(((((..(((......(((((.((....)).)))))...)))............)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.((((...........))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....))))))).(((.))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with pactamycin (co-crystallized), mRNA and deacylated tRNA in the P site; 23S Ribosomal RNA 4w2h DB 120 2.7 RF00001 URS000080DEE8_300852 25306919 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>>. .((((((((((....((((((.(....(((((((...(.....)...))))..)))...).)))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the Thermus thermophilus 70S ribosome in complex with pactamycin (co-crystallized), mRNA and deacylated tRNA in the P site; 5S Ribosomal RNA 4w2i AA 1496 2.7 RF00177,RF01959,RF01960 URS000080DFED_300852 25306922 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<....>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>.....<......>....>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<..<.<<<<<<<........>>>>>>>>...>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((..)))))))).)))))......(((......((((((((..((...(((((((.(((((....(.((((..)))).).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...((.((((....)))).))....(((....)))....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.. Crystal structure of the Thermus thermophilus 70S ribosome in complex with negamycin, mRNA and three deacylated tRNAs in the A, P and E sites; 16S Ribosomal RNA 4w2i AV 13 2.7 25306922 32630 aaaaauguucuaa ............. ............. Crystal structure of the Thermus thermophilus 70S ribosome in complex with negamycin, mRNA and three deacylated tRNAs in the A, P and E sites; mRNA 4w2i AW 74 2.7 RF00005 URS00005AA258_562 25306922 0030533 0006412 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<......>>>><<<<<<<.....>>>>>>.>...<<<<<.......>>>>>>>>>>>>.... (((((((..((((......)))).((((.........)))).....(((((.......)))))))))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with negamycin, mRNA and three deacylated tRNAs in the A, P and E sites; A/P-site tRNA 4w2i AX 76 2.7 RF00005 URS000041AF00_562 25306922 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with negamycin, mRNA and three deacylated tRNAs in the A, P and E sites; E-site tRNA 4w2i AY 74 2.7 RF00005 URS00005AA258_562 25306922 0030533 0006412 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[..)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with negamycin, mRNA and three deacylated tRNAs in the A, P and E sites; A/P-site tRNA 4w2i BA 2822 2.7 RF02540,RF02541,RF00002 URS00001698E8_300852 25306922 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagcggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgucgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<....<<<<<......>>>>.>....>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<...>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<...>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<..<......>..>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...((((((((.....))))))))....{.(((((((((...((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).))))....(((((((((.[.....)))))))))....}.(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((.(..(.(((......)))...))..)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.........)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((...)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((.((((((((.(......[..(((((..(((......((((............))))...)))..........].)))))).)))))))).)))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..((((.))))....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))....))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with negamycin, mRNA and three deacylated tRNAs in the A, P and E sites; 23S Ribosomal RNA 4w2i BB 120 2.7 RF00001 URS000080DEE8_300852 25306922 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the Thermus thermophilus 70S ribosome in complex with negamycin, mRNA and three deacylated tRNAs in the A, P and E sites; 5S Ribosomal RNA 4w2i CA 1503 2.7 RF00177,RF01959,RF01960 URS000080DFED_300852 25306922 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggau .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>....<<......>>...>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((((..((((((......)))))).(.(.((....)).).)))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}... Crystal structure of the Thermus thermophilus 70S ribosome in complex with negamycin, mRNA and three deacylated tRNAs in the A, P and E sites; 16S Ribosomal RNA 4w2i CV 12 2.7 25306922 32630 aaaauguucuaa ............ ............ Crystal structure of the Thermus thermophilus 70S ribosome in complex with negamycin, mRNA and three deacylated tRNAs in the A, P and E sites; mRNA 4w2i CW 72 2.7 RF00005 URS00005AA258_562 25306922 0030533 0006412 562 cccgganagcucagggagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<..<<<<.....>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>..... (((((...((((...[.)))).((((.........)))).....(((((..]....))))).)))))..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with negamycin, mRNA and three deacylated tRNAs in the A, P and E sites; A/P-site tRNA 4w2i CX 76 2.7 RF00005 URS000041AF00_562 25306922 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with negamycin, mRNA and three deacylated tRNAs in the A, P and E sites; E-site tRNA 4w2i CY 73 2.7 RF00005 URS00005AA258_562 25306922 0030533 0006412 562 gcccgganagcucagggagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<.....>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....)))).((((.........)))).....((.((.......)).))))))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with negamycin, mRNA and three deacylated tRNAs in the A, P and E sites; A/P-site tRNA 4w2i DA 2800 2.7 RF02540,RF02541,RF00002 URS00001698E8_300852 25306922 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>....<<<<<.....<......>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<..>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<.<<....>>.>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...((((((((.....))))))))....{.(((((((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).))))....(((((((((.[.....)))))))))....}.(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((()))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...((....(((.((((......(..........).......)))).)))...).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((((((()))))))))).))..........]]].)....))))))))))...)))))))(((((((())))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((....))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((.((((((((((((.(......[..(((((..(((......(((((.((....)).)))))...)))..........].)))))).)))))))))))).)))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....))))))).............(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))....))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with negamycin, mRNA and three deacylated tRNAs in the A, P and E sites; 23S Ribosomal RNA 4w2i DB 120 2.7 RF00001 URS000080DEE8_300852 25306922 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>>. .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the Thermus thermophilus 70S ribosome in complex with negamycin, mRNA and three deacylated tRNAs in the A, P and E sites; 5S Ribosomal RNA 4w4g QA 1511 3.3 RF00177,RF01959,RF01960 URS000080E226_300852 26508639 0003735 0005840 300852 guuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggcuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucaccuccuuu ......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<.>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<.<<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<......>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<...<<...<<<.....>>>.>>....>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.............. ......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((.((((.)))).)))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((((..(((((((....)))))))...(((......)))..))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}............. Postcleavage state of 70S bound to HigB toxin and AAA (lysine) codon; 16S rRNA 4w4g QV 77 3.3 RF00005 URS000041AF00_1403831 26508639 0030533 0006412 1403831 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Postcleavage state of 70S bound to HigB toxin and AAA (lysine) codon; tRNA fMet 4w4g QW 77 3.3 RF00005 URS000041AF00_1403831 26508639 0030533 0006412 1403831 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(.(((.......))).)))))))..... Postcleavage state of 70S bound to HigB toxin and AAA (lysine) codon; tRNA fMet 4w4g QX 18 3.3 26508639 562 caaggagguaaaaaugan .................. .................. Postcleavage state of 70S bound to HigB toxin and AAA (lysine) codon; messenger RNA 4w4g RA 2891 3.3 RF02540,RF02541,RF00002 URS000080DFFB_300852 26508639 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgggccggcccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<<<<<..>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<.<.<<<<<<......>>>>.>>>..>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..<<<<.......>>>>..>>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((.(.[[..[[.).).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((((((((..).))))))))....(.(((((((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((((((()))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((...((((((......)))).))...)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......(((((.(((..(((.........)))..))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((...........(((((..(((......((((((((....))))))))...)))............)))))..))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))..((((.....))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Postcleavage state of 70S bound to HigB toxin and AAA (lysine) codon; 23S rRNA 4w4g RB 122 3.3 RF00001 URS000080E212_300852 26508639 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga ..<<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> ..(((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).))))))))))) Postcleavage state of 70S bound to HigB toxin and AAA (lysine) codon; 5S rRNA 4w4g XA 1508 3.3 RF00177,RF01959,RF01960 URS000080E226_300852 26508639 0003735 0005840 300852 guuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucaccuccuuu ......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<..>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<........>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<...<<...<<<.....>>>.>>....>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.............. ......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((.(.))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((((((....)))))))...((.(.....)))...)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}............. Postcleavage state of 70S bound to HigB toxin and AAA (lysine) codon; 16S rRNA 4w4g XV 77 3.3 RF00005 URS000041AF00_1403831 26508639 0030533 0006412 1403831 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Postcleavage state of 70S bound to HigB toxin and AAA (lysine) codon; tRNA fMet 4w4g XW 77 3.3 RF00005 URS000041AF00_1403831 26508639 0030533 0006412 1403831 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(((((.......)))))))))))..... Postcleavage state of 70S bound to HigB toxin and AAA (lysine) codon; tRNA fMet 4w4g XX 18 3.3 26508639 562 caaggagguaaaaaugan .................. .................. Postcleavage state of 70S bound to HigB toxin and AAA (lysine) codon; messenger RNA 4w4g YA 2875 3.3 RF02540,RF02541,RF00002 URS000080DFFB_300852 26508639 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>....<<<<<.....<......>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<<........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>.>>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<...<<......<<<<<<<<....>>>>>>>>...>>.............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> .((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((((((((..).))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((.(.(.((((......))))..))..))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......(((((.(((..(((.........)))..))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(((((((...(((......(((((.(((....))))))))...)))..))))).)).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((((..))))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........(((((..(((......((((((((....))))))))...)))............)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.((((.....))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...))). Postcleavage state of 70S bound to HigB toxin and AAA (lysine) codon; 23S rRNA 4w4g YB 122 3.3 RF00001 URS000080E212_300852 26508639 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga ..<<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> ..(((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).))))))))))) Postcleavage state of 70S bound to HigB toxin and AAA (lysine) codon; 5S rRNA 4w5o B 20 1.802 URS000080E33F_32630 25359968 32630 uucacauugcccaagucuuu .................... .................... The Crystal Structure of Human Argonaute2 Bound to a Guide and Target RNA Containing Seed Pairing from 2-9; RNA (5'-R(P*UP*UP*CP*AP*CP*AP*UP*UP*GP*CP*CP*CP*AP*AP*GP*UP*CP*UP*UP*U)-3') 4w5o D 10 1.802 URS000080E203_32630 25359968 32630 caaugugaaa .......... .......... The Crystal Structure of Human Argonaute2 Bound to a Guide and Target RNA Containing Seed Pairing from 2-9; RNA (5'-R(*CP*AP*AP*UP*GP*UP*GP*AP*AP*A)-3') 4w5q B 18 3.101 URS000080E33F_32630 25359968 32630 uucacauugcccaagucu .................. .................. The Crystal Structure of Human Argonaute2 Bound to a Guide and Target RNA Containing Seed Pairing from 2-8; RNA (5'-R(P*UP*UP*CP*AP*CP*AP*UP*UP*GP*CP*CP*CP*AP*AP*GP*UP*CP*U)-3') 4w5q D 10 3.101 URS000080E2A8_32630 25359968 32630 aaaugugaaa .......... .......... The Crystal Structure of Human Argonaute2 Bound to a Guide and Target RNA Containing Seed Pairing from 2-8; RNA (5'-R(*AP*AP*AP*UP*GP*UP*GP*AP*AP*A)-3') 4w5r B 11 2.5 URS000080E33F_32630 25359968 32630 uucacauuguu ........... ........... The Crystal Structure of Human Argonaute2 Bound to a Guide and Target RNA Containing Seed Pairing from 2-8 (Long Target); RNA (5'-R(P*UP*UP*CP*AP*CP*AP*UP*UP*GP*UP*U)-3') 4w5t B 16 2.5 URS000080E33F_32630 25359968 32630 uucacauugcccaauu ................ ................ The Crystal Structure of Human Argonaute2 Bound to a Guide and Target RNA Containing Seed Pairing from 2-7; RNA (5'-R(P*UP*UP*CP*AP*CP*AP*UP*UP*GP*CP*CP*CP*AP*AP*UP*U)-3') 4w5t D 10 2.5 URS000080E1E5_32630 25359968 32630 acaugugaaa .......... .......... The Crystal Structure of Human Argonaute2 Bound to a Guide and Target RNA Containing Seed Pairing from 2-7; RNA (5'-R(*AP*CP*AP*UP*GP*UP*GP*AP*AP*A)-3') 4wce X 2708 3.526 RF02540,RF02541 URS00001450D9_93061 26464510 0003735 0005840 93061 gauuaaguuauuaagggcgcacgguggaugccuuggcacuagaagccaaugaaggacguuacuaacgacgauaugcuuuggggagcuguaaguaagcuuugauccagagauuuccgaauggggaaacccagcaugaguuaugucauguuaucgauauguauacauagcauaucagaaggcacacccggagaacugaaacaucuuaguacccggaggaagagaaagaaaauucgauucccuuaguagcggcgagcgaaacgggaagagcccaaaccaacaagcuugcuuguugggguuguaggacacucuaugaguuacaaaggacgacauuagacgaaucaucuggaaagaugaaucaaagaagguaauaauccuguagucgaaaauguugucucucuugaguggauccugaguacgacggagcacgugaaauuccgucggaaucugggaggaccaucuccuaaggcuaaauacucucuagugaccgauagugaaccaguaccgugagggaaaggugaaaagcaccccggaaggggagugaaauagaaccugaaaccgugugcuuacaaguagucagagcccguuaaugggugauggcgugccuuuuguagaaugaaccggcgaguuacgauuugaugcaagguuaagcaguaaauguggagccguagcgaaagcgagucugaauagggcguuuaguauuuggucguagacccgaaaccaggugaucuacccuuggucagguugaaguucaggcugaauggaggaccgaaccgacuuacguugaaaagugagcggaugaacugaggguagcggagaaauuccaaucgaaccuggagauagcugguucucuccgaaauagcuuuagggcuagccucaagugaugauuauuggagguagagcacuguuuggacgaggguuaccgaauucagacaaacuccgaaugccaauuaauuuaacuugggagucagaacaugggugauaagguccguguucgaaagggaaacagcccagaccaccagcuaaggucccaaaauauauguuaaguggaaaaggauguggcguugcccagacaacuagcucacuagucgagugacacugcgccgaaaauguaccggggcuaaacauauuaccgaagcuguggauuguccuuggacaaugguaggagagcguucuaagggcguugaagcaugaucguaaggacauguggagcgcuuagaagugagaaugccggugugaguagcgaaagacgggugagaaucccguccaccgauugacuaagguuuccagaggaaggcucguccgcucuggguuagucggguccuaagcugaggccgacaggcguaggcgauggauaacagguugauauuccuguaccaccuauaaucguaucgauggggggacgcaguaggauaggcgaagcgugcgauuggauugcacgucuaagcaguaggcgaguaauccgguacucgggcugagcugugauggggagaagagagucguugauuucacacugccgagaaaagccucuagauagaauaggugcccguaccgcaaaccgacacagguagucaagaugagaauucuaaggugagcgagcgaacucucguuaaggaacucggcaaaaugaccccguaacuucgggagaaggggugcucuuuaggguuaacgcccagaagagccgcagugaauaggcccaagcgacuguuuaucaaaaacacaggucucugcuaaaccguaaggugauguauaggggcugacgccugcccgugcuggaagguuaagaggagugguuagcugcgaagcuacgaaucgaagccccaguaaacggcggcuaagguagcgaaauuccuugucggguaaguuccgacccgcacgaaaggcguaacgauuugggcacugucucaacgagagacucggugaaaucauaguaccugugaagaugcagguuacccgcgacaggacggaaagaccccguggagcuuuacuguagccugauauugaaauucggcuuucuaacccgcaccacuuaucguggugggagacagugucaagcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcucaaagguucccucagaaugguugaaaucauucauagaguguaaaggcauaagggagcuugacugcgagaccuacaagucgagcagggucgaaagacggacuuagugauccggugguuccgcauggaagggccaucgcucaacggauaaaagcuaccccggggauaacaggcuuaucucccccaagaguucacaucgacggggagguuuggcaccucgaugucggcucaucgcauccuggggcuguagucggucccaaggguugggcuguucgcccauuaaagcgguacgcgagcuggguucagaacgucgugagacaguucggucccuauccgucgugggcguaggaaauuugagaggagcuguccuuaguacgagaggaccgggauggacauaccucugguguaccaguugucgugccaacggcauagcuggguagcuauguguggacgggauaagugcugaaagcaucuaagcaugaagccccccucaagaugagauuucccaacuugguuauaagaucccucaaagaugaugagguuaauagguucgagguggaagcauggugacauguggagcugacgaauacuaaucgaucgaagacuuaau ..<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<<<<<<<<.......>>>>>>>.>>.>>....<<<<<......<......>.......>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..(((....<<<<<<<<....>>>>>>>>......<<<<<<<<<...<..........<..<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>...>...>.>>>>>..>>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<....>>>>..................>>>>>>>>>>>.......<<<<..<<<<......>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<.<<<<<..<<<...<<.......>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>.>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<.>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<...<<<<<<<<<.....<<<...<<<<<<<<...<......>...>>>>>>>>..>>.>.....>>>>.>>>>>..>>>>>>>.>>..<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<.<<<<........<<<<......>>>>....>>>>.>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<..>>>>>>>....>>>>>><.<<<<<<<.<<......<<<<<.<<....>>.>>>>>...>>.>>>>>>>..>.....>>>>>><......<<....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<.<.<<<...<<<....>>>...>>>..>>>...<<<<<........>>>>>))<<<<<<<......<<<...<<<<....<<<<...<<...<......<<<...{.{...>>>...<....<<<<<.<<<<<<<........>>>>..>>>..>>>>>.....>..............>....>>...>>>>.........>>>.>.>>>...>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<....>.>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<<.<<<<....>>>>.>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<..<<.<<<<<<<..<<<<..<<...<<<<<..<<.>>...>>>>>...>>..>>>>>>>>>..>>>>...........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<.<<<<<<.<<<<.<..>.>>>>....<<.<<<<<<.....>>>>>>>>.....>>>>>>.>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.}.}>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>. ..((((((......((((((((((.....(((..((((((((.((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))(((((((......))))))).((((((((.........)))))).)).))....(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((((..........)))))....[.(((.(((((.................((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))).........)))))...))))....(((((((...{.......)))))))....].(((((}.[[[[)))))..)))......))..)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((..((((..[...))))..)))).<.(.(........).).((((((..(.(((((((.(((((..(((...((.......))...)))...((....))...(((.....)))......))))).)))))))..((.(...((((((.....((((((((((.((((...(((((...)))))...)<)))...(((.(((((.......A))))))))..).))))))))).(.(((....[)))...).]))))))......).))).((((((....(((((....)))))(((((((((...(((((((((.....(((...(((.((((..............)))).)))..)).).....)))).)))))..))))))).))..((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((.(((((.....{.((..........))...))))).)))).))...........]]].)...))))))))))...)))))))(((((((..)))))))....))))))(.(((((((.((......(((((.((....))])))))...)).)))))))..).....))))))(......((....((((((.......))))))((((....(((...((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]]((((((....(...((...((((....((((...((...(..............{...............(((...(((.(.(......).).)..))....))).....................)....))...))))(..).....))))..))..)..)))))))))).))).....((......))..))).(((.......)))..))))..((((....((((((((.((..(....(.......(((((....(.[..).....)))))(((((.....((....)).....)))))(...).......(((((((((.>.((.........))...(((((((.....(((....))).......))))))).]((((..((.(((((((..(((...((....((((..((.))...))))....))...))))))))..))))...(...)...((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).[..(((((.....>].)))))..((((((((.(((.((......((((.((((((..(((((.((.((((((.((((..()..))))....((..(((((.....))))).)).....)))))).))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((........)))))...).(.][.[[[.)....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..a.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}..))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))((((...)))....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))...))))))). The crystal structure of the large ribosomal subunit of Staphylococcus aureus; 23S rRNA 4wce Y 114 3.526 RF00001 URS00003DF33D_93061 26464510 0003735 0005840 93061 ucuggugacuauagcaaggaggucacaccuguucccaugccgaacacagaaguuaaggucuuuagcgacgaugguagccaacuuacguuccgcuagaguagaacguugccaggc .<<.<..<.....<<<<<<<......<<<<<...............>>>..>>.....>>>>>.>><.........<.<............>.>.........>..>..>.>>. .(..(..(.....((((.((......((((((.............))))..)).....)).)).))........................................)..)..). The crystal structure of the large ribosomal subunit of Staphylococcus aureus; 5S rRNA 4wf1 AA 1538 3.09 RF00177,RF01959,RF01960 URS000080DDC0_511145 25368144 0003735 0005840 511145 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccucc .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<.<<........>.>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<<..>>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>.>..........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<.<......<<........>>..........<<<<<<<........<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>....<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<<..<<<.....>>>>>.....>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>..>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>........... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((...(.(....).)...).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..(......))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(..(.((((((((.......)))))))).)...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((.(..(...(((((((..(((((((....)))))))....(....)...))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....).)))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.......... Crystal structure of the E. coli ribosome bound to negamycin.; 16S rRNA 4wf1 BA 2897 3.09 RF02540,RF02541 URS000080E25C_511145 25368144 0003735 0005840 511145 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<<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<.>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<....<...........>....>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<.<......>.>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>..>.....>>>>>>>>..>>>>>.<<<<<.......>>>>>.........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<..<<<......<<<.<<<<....>>>>.>>>...>>>............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. 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Crystal structure of the E. coli ribosome bound to negamycin.; 23S rRNA 4wf1 BB 119 3.09 RF00001 URS000080E133_511145 25368144 0003735 0005840 511145 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>> ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))) Crystal structure of the E. coli ribosome bound to negamycin.; 5S rRNA 4wf1 CA 1539 3.09 RF00177,RF01959,RF01960 URS000080DDC0_511145 25368144 0003735 0005840 511145 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<<....>>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<.<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<...<<<.....>>>.>.....>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>..>>>>>>>>.....<<<<<<<.....<<<..<....<<<....>>>....>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((((....))))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..(......))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(..(.((((((((.......)))))))).)...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...(((((((.....(((((((...((........))......)))))))............((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..(((((((.((......((........))..........(((...(..(...((((.((...((((((....))))))..............)).)).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((....(..(((.....)))).....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)...)))...))..))))))).(...(((((((.....(((..((....((....))....))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Crystal structure of the E. coli ribosome bound to negamycin.; 16S rRNA 4wf1 DA 2897 3.09 RF02540,RF02541 URS000080E25C_511145 25368144 0003735 0005840 511145 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<.>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<...........>>...>>.........<<......>>...>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<..<<....>>...>>>>>..>....>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>...>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))((((..(....)..)))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((((((.)))).))...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(.(...(............)..).).........((......).)..)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((.(.(......).).))))....))))))(.(((((...(((......(((.((((....)))).)))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((.(...((.....)).).))))....[[(((.(.(.(.(((...(((....)))...)))..)).)..(((((........)))))]](((((((((((((...((((.....(((..(((..((((((((((((...{{{.).)))))).(..((((...((((((((((((.((.....))))))))))..))))..[))))...).(..(((((....)))))...))))))...)))...))).(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((...((((.(((.(((((.((((((.((((.((((.(.........(((((..(((......((((((((....))))))))...)))............)))))).)))).)))).))))))...(((.((((((.....)))))))))....))))).)))..))))...(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Crystal structure of the E. coli ribosome bound to negamycin.; 23S rRNA 4wf1 DB 118 3.09 RF00001 URS000080E133_511145 25368144 0003735 0005840 511145 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))). Crystal structure of the E. coli ribosome bound to negamycin.; 5S rRNA 4wf9 X 2712 3.427 RF02540,RF02541 URS00001450D9_93061 26464510 0003735 0005840 93061 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The crystal structure of the large ribosomal subunit of Staphylococcus aureus in complex with telithromycin; 23S ribosomal RNA 4wf9 Y 114 3.427 RF00001 URS00003DF33D_93061 26464510 0003735 0005840 93061 ucuggugacuauagcaaggaggucacaccuguucccaugccgaacacagaaguuaaggucuuuagcgacgaugguagccaacuuacguuccgcuagaguagaacguugccaggc .<<.<..<.....<<<<<<<......<<<<<...............>>>..>>.....>>>>>.>><....<....<.<............>.>.....>...>..>..>.>>. .(..(..(.....((((.((......((((((...(.....)...))))..)).....)).)).))........................................)..)..). The crystal structure of the large ribosomal subunit of Staphylococcus aureus in complex with telithromycin; 5S ribosomal RNA 4wfa X 2711 3.392 RF02540,RF02541 URS00001450D9_93061 26464510 0003735 0005840 93061 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The crystal structure of the large ribosomal subunit of Staphylococcus aureus in complex with linezolid; 23S rRNA 4wfa Y 114 3.392 RF00001 URS00003DF33D_93061 26464510 0003735 0005840 93061 ucuggugacuauagcaaggaggucacaccuguucccaugccgaacacagaaguuaaggucuuuagcgacgaugguagccaacuuacguuccgcuagaguagaacguugccaggc .<<.<..<.....<<<<<<<......<<<<<...............>>>..>>.....>>>>>.>><.........<.<............>.>.........>..>..>.>>. .(..(..(.....((((.((......((((((.............))))..)).....)).)).))........................................)..)..). The crystal structure of the large ribosomal subunit of Staphylococcus aureus in complex with linezolid; 5S rRNA 4wfb X 2707 3.43 RF02540,RF02541 URS00001450D9_93061 26464510 0003735 0005840 93061 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The crystal structure of the large ribosomal subunit of Staphylococcus aureus in complex with BC-3205; 23S rRNA 4wfb Y 114 3.43 RF00001 URS00003DF33D_93061 26464510 0003735 0005840 93061 ucuggugacuauagcaaggaggucacaccuguucccaugccgaacacagaaguuaaggucuuuagcgacgaugguagccaacuuacguuccgcuagaguagaacguugccaggc .<<.<..<.....<<<<<<<......<<<<<...............>>>..>>.....>>>>>.>><.........<.<............>.>.........>..>..>.>>. .(..(..(.....((((.((......((((((.............))))..)).....)).)).))........................................)..)..). The crystal structure of the large ribosomal subunit of Staphylococcus aureus in complex with BC-3205; 5S rRNA 4wfn X 2680 3.54 RF02540,RF02541 URS000080DEF1_243230 28689968 0003735 0005840 243230 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Crystal structure of the large ribosomal subunit (50S) of Deinococcus radiodurans containing a three residue insertion in L22 in complex with erythromycin; 23S ribosomal RNA 4wfn Y 122 3.54 RF00001 URS0000420396_243230 28689968 0003735 0005840 243230 cacccccgugcccauagcacuguggaaccaccccaccccaugccgaacugggucgugaaacacagcagcgccaaugauacucggaccgcagggucccggaaaagucggucagcgcggggguu .<<<<<<<<<<.....<<.<<<<<....<<<<<<<.............>>>>..>>>...>>>>>..>><<<.....<.<<.<<<<<....>>>>>.>>...>...>>>..>>>>>>>>>>. .((((((((((.....((.(.(((....(((.((....(.....)....))...)))...))).)..)).((.......((.(((((....))))).)).......))...)))))))))). Crystal structure of the large ribosomal subunit (50S) of Deinococcus radiodurans containing a three residue insertion in L22 in complex with erythromycin; 5S ribosomal RNA 4woi AA 1538 3.0 RF00177,RF01959,RF01960 URS00000ABFE9_1110693 26224058 0003735 0005840 1110693 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.......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<.<<<....>>>.>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>........... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((..((......))..)).)))))..)))))......(((......(((((((..((...(((((((.(.((.....(((..(....)..)))......)).).....(((....)))....((((((...(.....))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))...((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))...)))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((.((..(.((.((....)).)).)...((....))..)).)).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..((.......))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...((.(((......(((..((...(((....)))...))....)))......))).))......(.....((((((........)))))).....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.......... 4,5-linked aminoglycoside antibiotics regulate the bacterial ribosome by targeting dynamic conformational processes within intersubunit bridge B2; 16S ribosomal RNA 4woi AW 15 3.0 26224058 268588 aggagguaaaauucu ............... ............... 4,5-linked aminoglycoside antibiotics regulate the bacterial ribosome by targeting dynamic conformational processes within intersubunit bridge B2; Messenger RNA 4woi AX 76 3.0 RF00005 URS00005AA258_1110693 26224058 0030533 0006412 1110693 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<.<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>.>>>.... ....((...((((.....[..)))).(((((.......))))).....(.((...].....)).).))........ 4,5-linked aminoglycoside antibiotics regulate the bacterial ribosome by targeting dynamic conformational processes within intersubunit bridge B2; Phenylalanine specific transfer RNA, tRNA-Phe 4woi BA 2897 3.0 RF02540,RF02541 URS00004B0F34_1110693 26224058 0003735 0005840 1110693 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<......>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<.....>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<...........>>...>>........<<........>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<.........>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<<.<<....>>..>>>>>>..>....>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<....<.<<...............<.................................................>......>>.>....>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((.(......).)))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....(((((((((..((((...((((((......))))))...)[)))...(((.(((((........))))))))....))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((..........))...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((......(.............)..........(..(..........)).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((..(........)..))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((..((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...(((((((((((..((.....)).)))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))......))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((......]..))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..(......)...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((((.........................(.................................................)................))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). 4,5-linked aminoglycoside antibiotics regulate the bacterial ribosome by targeting dynamic conformational processes within intersubunit bridge B2; 23S ribosomal RNA 4woi BB 119 3.0 RF00001 URS0000049E57_1110693 26224058 0003735 0005840 1110693 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>> .(((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))). 4,5-linked aminoglycoside antibiotics regulate the bacterial ribosome by targeting dynamic conformational processes within intersubunit bridge B2; 5S ribosomal RNA 4woi CA 2897 3.0 RF02540,RF02541 URS00004B0F34_1110693 26224058 0003735 0005840 1110693 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<......>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<..........>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<...........>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<.....<<<...<<.........>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<...<<..<<<............<<<<<...<.......<<<<<<<......>>>>>>>....>.............>>>>.>..>>>..>>...>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((..........))...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(.(((.(.(..(((.........)))..).)........(((......)))..))).)...)))..))))).))...........]]].)...))))))))))...)))))))((((.(.((....)).).))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(.......(.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((.(((((((.((.....)))))))))...)))...[))))...))(...(..........)....))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...........].......)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((.........((((..((....))...)))).........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))......)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((....((..((.............((.(............(.((.(((....))).)).)...................).))....))..))....))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((]..[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].......(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((.(....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). 4,5-linked aminoglycoside antibiotics regulate the bacterial ribosome by targeting dynamic conformational processes within intersubunit bridge B2; 23S ribosomal RNA 4woi CB 118 3.0 RF00001 URS0000049E57_1110693 26224058 0003735 0005840 1110693 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (((((((((.....((((((((....(((((((.............))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))). 4,5-linked aminoglycoside antibiotics regulate the bacterial ribosome by targeting dynamic conformational processes within intersubunit bridge B2; 5S ribosomal RNA 4woi DA 1539 3.0 RF00177,RF01959,RF01960 URS00000ABFE9_1110693 26224058 0003735 0005840 1110693 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<...<<<<<<<<<......>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<..<<<<....>>>>..>...<......>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((.((((((....))))))..)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((........))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((((.......)))))))).....)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((((.......)))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((......(((....))).......((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... 4,5-linked aminoglycoside antibiotics regulate the bacterial ribosome by targeting dynamic conformational processes within intersubunit bridge B2; 16S ribosomal RNA 4woi DV 16 3.0 26224058 268588 aaggagguaaaauucu ................ ................ 4,5-linked aminoglycoside antibiotics regulate the bacterial ribosome by targeting dynamic conformational processes within intersubunit bridge B2; Messenger RNA 4woi DW 76 3.0 RF00005 URS00005AA258_1110693 26224058 0030533 0006412 1110693 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).(((((.......))))).....(((((..]....)))))))))))).... 4,5-linked aminoglycoside antibiotics regulate the bacterial ribosome by targeting dynamic conformational processes within intersubunit bridge B2; Phenylalanine specific transfer RNA, tRNA-Phe 4wpo AA 2872 2.8 RF02540,RF02541,RF00002 URS00001698E8_300852 25594181 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<.<.<<<<<<......>>>>.>>.>.>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<.<<<..>>>.>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...((((((((.....))))))))....{.(((((((((...((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).))))....(((((((((.[.....)))))))))....}.(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((......(((......)).)......)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{..((.(.(((..(((.........)))..))).....(...((......)).).).))....)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((.((((((((.(......[..(((((..(((......((((.(((....))).))))...)))..........].)))))).)))))))).)))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((.))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with elongation factor G in the pre-translocational state; 23S Ribosomal RNA 4wpo AB 120 2.8 RF00001 URS000080DEE8_300852 25594181 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> (((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).))))))))))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with elongation factor G in the pre-translocational state; 5S Ribosomal RNA 4wpo BA 1497 2.8 RF00177,RF01959,RF01960 URS000080DFED_300852 25594181 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccucgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<.....>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>.....<......>....>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<...<<<..<<<.....>>>>>>....>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((((((....))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((...))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((((((....)))))))....((......))....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((.(..(((..(((.....))))))...).))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Crystal structure of the Thermus thermophilus 70S ribosome in complex with elongation factor G in the pre-translocational state; 16S Ribosomal RNA 4wpo BV 13 2.8 25594181 32630 aaaaauguucuaa ............. ............. Crystal structure of the Thermus thermophilus 70S ribosome in complex with elongation factor G in the pre-translocational state; mRNA 4wpo BW 74 2.8 RF00005 URS00005AA258_1403831 25594181 0030533 0006412 1403831 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcaccn <<<<<<<..<<<<......>>>><<<<<<<.....>>>>>>.>...<<<<<.......>>>>>>>>>>>>.... ..(((((..((((......)))).((((.........)))).....(((((.......))))))))))...... Crystal structure of the Thermus thermophilus 70S ribosome in complex with elongation factor G in the pre-translocational state; A-site tRNA 4wpo BX 76 2.8 RF00005 URS000041AF00_1403831 25594181 0030533 0006412 1403831 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaaccn <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with elongation factor G in the pre-translocational state; P-site tRNA 4wpo BY 74 2.8 RF00005 URS00005AA258_1403831 25594181 0030533 0006412 1403831 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((......)))).((((.........)))).....(((((.......)))))))))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with elongation factor G in the pre-translocational state; E-site tRNA 4wpo CA 2868 2.8 RF02540,RF02541,RF00002 URS00001698E8_300852 25594181 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<...........<<.<<...<<<<.......>>>>...>>.........<<......>>...>>.......>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<..>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<<..>>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((..))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((......(.(......).).......)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((.(.....{.....(...(..(.............)..)...........((......))...).......).)))))))).))..........]]].)....))))))))))...)))))))(((((((())))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((..((((((((.(......[..(((((..(((.......(((((((....)))))))....)))..........].)))))).))))))))..))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))((((.))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with elongation factor G in the pre-translocational state; 23S Ribosomal RNA 4wpo CB 120 2.8 RF00001 URS000080DEE8_300852 25594181 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>>. .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the Thermus thermophilus 70S ribosome in complex with elongation factor G in the pre-translocational state; 5S Ribosomal RNA 4wpo DA 1503 2.8 RF00177,RF01959,RF01960 URS000080DFED_300852 25594181 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggau .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<......>>....>>>>>>>..<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<...<<<..<<<.....>>>>>>....>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>....>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...((((((......)))))).....((....)).....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(.(((((..(((..(((.....))))))...))))).)..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}... Crystal structure of the Thermus thermophilus 70S ribosome in complex with elongation factor G in the pre-translocational state; 16S Ribosomal RNA 4wpo DV 12 2.8 25594181 32630 aaaauguucuaa ............ ............ Crystal structure of the Thermus thermophilus 70S ribosome in complex with elongation factor G in the pre-translocational state; mRNA 4wpo DW 72 2.8 RF00005 URS00005AA258_1403831 25594181 0030533 0006412 1403831 cccgganagcucagggagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcaccn <<<<<<..<<<<.....>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((...(((...[.)))..((((.........)))).....(((((..]....)))))))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with elongation factor G in the pre-translocational state; A-site tRNA 4wpo DX 76 2.8 RF00005 URS000041AF00_1403831 25594181 0030533 0006412 1403831 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaaccn <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with elongation factor G in the pre-translocational state; P-site tRNA 4wpo DY 73 2.8 RF00005 URS00005AA258_1403831 25594181 0030533 0006412 1403831 gcccgganagcucagggagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<.....>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....)))).((((.........)))).....(((((.......)))))))))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with elongation factor G in the pre-translocational state; E-site tRNA 4wq1 13 1498 3.1 RF00177,RF01959,RF01960 URS000080E226_300852 26037619 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<.>>.>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<......>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(.(((((....))))).).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(.(((....))).).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))..........((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((((..(((((((....)))))))...(((.....).))..))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...(...(((.....))).)....))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))... Complex of 70S ribosome with tRNA-Tyr and mRNA with C-A mismatch in the first position in the A-site.; 16S ribosomal RNA 4wq1 1K 85 3.1 RF00005 URS00002D9DE2_83333 26037619 0030533 0006412 83333 gguggggnucccgagcngccaaagggagcagacunuanaucugccgucaucgacuucgaaggnucgaauccuucccccaccacca <<<<<<<..<<<...........>>>.<<<<<.......>>>>>.<<<...>>>...<<<<<.......>>>>>>>>>>>>.... (((((((..(((...........))).((((.........))))..((...))....(((((.......)))))))))))).... Complex of 70S ribosome with tRNA-Tyr and mRNA with C-A mismatch in the first position in the A-site.; tRNA-Tyr 4wq1 2K 77 3.1 RF00005 URS000057545F_83333 26037619 0030533 0006412 83333 cgcggggnggagcagcccggnagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Complex of 70S ribosome with tRNA-Tyr and mRNA with C-A mismatch in the first position in the A-site.; tRNA-fMET 4wq1 3K 74 3.1 RF00005 URS00002D9DE2_83333 26037619 0030533 0006412 83333 gguggggnucccgagcngccaaagggagcagacunuanaucugcccgaaggnucgaauccuucccccaccacca <<<<<<<..<<<...........>>>.<<<<<.......>>>>>..<<<<<.......>>>>>>>>>>>>.... (((((((..(((...........))).((((.........))))..(((((.......)))))))))))).... Complex of 70S ribosome with tRNA-Tyr and mRNA with C-A mismatch in the first position in the A-site.; tRNA-Tyr 4wq1 4K 15 3.1 26037619 300852 aaaaaugcacaaaaa ............... ............... Complex of 70S ribosome with tRNA-Tyr and mRNA with C-A mismatch in the first position in the A-site.; mRNA 4wq1 1H 2912 3.1 RF02540,RF02541,RF00002 URS000080E23D_300852 26037619 0003735 0005840 300852 ggucaagaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaacggcccgcacgcgggccgaaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggauguuggcuuagaagcagccaucauuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucuugacc .<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.....>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....<<<<<<......>>>>>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<.<......>.>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<.........>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<..<<<<<<<...<<.......>>...>>>>>>>...>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>>. ((((((((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....((((((((..[......))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....((((((......))))))....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((...((...............))...)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......(((((..((..(.(.........).)..))..........((......))...)))))...)))))))))).))..........]]].)....))))))))))...)))))))(((((((.......)))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((.(((((((.((.....)))))))))......))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((.((((((((((((.(.........(((((..(((......(.((((((....)))))).)...)))............)))))).)))))))))))).)))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.(((.......)).)...(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...))))))))) Complex of 70S ribosome with tRNA-Tyr and mRNA with C-A mismatch in the first position in the A-site.; 23S ribosomal RNA 4wq1 16 122 3.1 RF00001 URS00005AB4A7_300852 26037619 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga ..<<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> ..(((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).))))))))))) Complex of 70S ribosome with tRNA-Tyr and mRNA with C-A mismatch in the first position in the A-site.; 5S ribosomal RNA 4wq1 1G 1498 3.1 RF00177,RF01959,RF01960 URS0000868551_300852 26037619 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<......>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<...<<<.....>>>.>.....>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((..)))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((((..(((((((....)))))))....(((....)))...))))))))).((.(((...((((.(.(....(((((((((....)))...(((......)))...)))))).....((((.((((((........(((.....))).......)))))).....(((((....)))))........)))).....).)..))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Complex of 70S ribosome with tRNA-Tyr and mRNA with C-A mismatch in the first position in the A-site.; 16S ribosomal RNA 4wq1 1L 74 3.1 RF00005 URS00002D9DE2_83333 26037619 0030533 0006412 83333 gguggggnucccgagcngccaaagggagcagacunuanaucugcccgaaggnucgaauccuucccccaccacca <<<<<<<..<<<...........>>>.<<<<<.......>>>>>..<<<<<.......>>>>>>>>>>>>.... ((..((...(((.....[.....))).((((.........))))..(((((..]....))))).))..)).... Complex of 70S ribosome with tRNA-Tyr and mRNA with C-A mismatch in the first position in the A-site.; tRNA-Tyr 4wq1 2L 77 3.1 RF00005 URS000057545F_83333 26037619 0030533 0006412 83333 cgcggggnggagcagcccggnagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Complex of 70S ribosome with tRNA-Tyr and mRNA with C-A mismatch in the first position in the A-site.; tRNA-fMET 4wq1 3L 75 3.1 RF00005 URS00002D9DE2_83333 26037619 0030533 0006412 83333 gguggggnucccgagcngccaaagggagcagacunuanaucugccucgaaggnucgaauccuucccccaccacca <<<<<<<..<<<...........>>>.<<<<<.......>>>>>...<<<<<.......>>>>>>>>>>>>.... (((((((..(.......[.......).((((.........))))...(((((..]....)))))))))))).... Complex of 70S ribosome with tRNA-Tyr and mRNA with C-A mismatch in the first position in the A-site.; tRNA-Tyr 4wq1 4L 16 3.1 26037619 300852 aaaaaaaugcacaaaa ................ ................ Complex of 70S ribosome with tRNA-Tyr and mRNA with C-A mismatch in the first position in the A-site.; mRNA 4wq1 14 2907 3.1 RF02540,RF02541,RF00002 URS000080E23D_300852 26037619 0003735 0005840 300852 ggucaagaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaacggcccgcacgcgggccgaaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggauguuggcuuagaagcagccaucauuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucuugacc .<..<<<<......<<<<<<<<<<<.....[[..[[<<<<<<[[<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<..>>>>>>.>>....<<<<<.....<<....>>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...(((....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>.]]...............<<....>>....]].........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....<<<<<<......>>>>>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<......<.<<<<<.<<...<<<.........>>>...>>.........<<......>>...>>>>>.>..>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..((((...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.........<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<.......<<<<<<<<..>>>>>>>.>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<.(((..>>>>..)))>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.....>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))))>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>...> .....(((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((.(..).)))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((.(((((..).)))).)))....(.(((((((((.....((...(((((.((((.(((...(((((......)))))[[......(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....((((((......))))))....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((...((...............))...)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{..((((.(((..((.(.......).))..))).....(...((......)).).))))....)))))))))).))..........]]].)....))))))))))...)))))))(((((((.......)))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((.(((((.((((((.(.........(((((..((........(((((((....)))))).)....))............)))))).)))))).))))).)))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.....))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((.....))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...))))..... Complex of 70S ribosome with tRNA-Tyr and mRNA with C-A mismatch in the first position in the A-site.; 23S ribosomal RNA 4wq1 1J 122 3.1 RF00001 URS00005AB4A7_300852 26037619 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga ..<<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>>> ..(((((((((((....((((((.(....(((((((...(.....)...))))..)))...).)))).))(((.......((.(((((....))))).)).......))).))))))))))) Complex of 70S ribosome with tRNA-Tyr and mRNA with C-A mismatch in the first position in the A-site.; 5S ribosomal RNA 4wqf AA 2852 2.8 RF02540,RF02541,RF00002 URS00001698E8_300852 25594181 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<........<<<<<<..................<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>.....>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<.<<<<<<<...........<<<<<..<<<......<<<<<.<<<..>>>.>>>>>...>>>............>>>>>..>>>>>>>.>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((..(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((.(.(...((......))....))..))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...(((......(.((((((.....(............(((((((.....{..((.(.(((..(((.........)))..))).....(...((......)).).).))....))))))))....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........((.((..(((......((((...(....)...))))...)))............)).))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((.))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with elongation factor G and fusidic acid in the post-translocational state; 23S Ribosomal RNA 4wqf AB 120 2.8 RF00001 URS000080DEE8_300852 25594181 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> (((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).))))))))))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with elongation factor G and fusidic acid in the post-translocational state; 5S Ribosomal RNA 4wqf BA 1495 2.8 RF00177,RF01959,RF01960 URS000080DFED_300852 25594181 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccucgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcggucguaacaagguagcuguaccggaaggugcggcugga .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<.....>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>....<<......>>...>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<...<<<.....>>>.>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>>.>>...>.....<<<<<<<<<....>>>>>>>>>... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((.(......).)))).)))))......(((......((((((((..((...(((((((.(.(((......(((......))).......))).)....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((...))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((.(.....(((.(((....))).)))....((......))......).)))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(.(..(((.....)))).)...))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(.(((((.....(((..(((.((((....))))).))....))).....))))).)......(....(((((((........)))))))....)..)..))))).....(((((((..........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))).))...)..)..(((((((((....)))))))))}.. Crystal structure of the Thermus thermophilus 70S ribosome in complex with elongation factor G and fusidic acid in the post-translocational state; 16S Ribosomal RNA 4wqf BW 76 2.8 RF00005 URS00005AA258_1403831 25594181 0030533 0006412 1403831 gcccgganagcucagucgguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with elongation factor G and fusidic acid in the post-translocational state; P-site tRNA 4wqf BY 74 2.8 RF00005 URS00005AA258_1403831 25594181 0030533 0006412 1403831 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((......)))).((((.........)))).....(((((.......)))))))))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with elongation factor G and fusidic acid in the post-translocational state; P-site tRNA 4wqf CA 2848 2.8 RF02540,RF02541,RF00002 URS00001698E8_300852 25594181 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<........<<<<<<..................<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>.....>>>>>>.>>>...>>>>>>><<<<<<<<>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<<..>>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...((((((((.....))))))))....{.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).))))....(((((((((.[.....)))))))))....}.(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((..))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((....(.(.(......).)..)....)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...(((......(.((((((.....(............(((((((.....{.((.((..((..(((.........)))..))......(...((......)).).)).))...))))))))....))))))))))...)))))))(((((((())))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((.(((((((((.(......[..((.((...((......((.((.((....)).)).))...))...........].)).))).))))))))).))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))((((.))).....(((((((((.......)))))....((((((((.(((....(.(((....))).)...)))..))))).)))...))))...)))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with elongation factor G and fusidic acid in the post-translocational state; 23S Ribosomal RNA 4wqf CB 120 2.8 RF00001 URS000080DEE8_300852 25594181 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>>. .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the Thermus thermophilus 70S ribosome in complex with elongation factor G and fusidic acid in the post-translocational state; 5S Ribosomal RNA 4wqf DA 1501 2.8 RF00177,RF01959,RF01960 URS000080DFED_300852 25594181 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcggucguaacaagguagcuguaccggaaggugcggcuggau .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<.<...<<<<<<<....>>>>>>>....<<......>>....>.>>>>>..<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<...<<<.....>>>.>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>....>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>>.>>...>.....<<<<<<<<<....>>>>>>>>>.... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...(((.....))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((.((...((((.(......).)))).(...((....))...).)).))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(.(((((..(((..(((.....))))))...))))).)..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))).))...)..)..(((((((((....)))))))))}... Crystal structure of the Thermus thermophilus 70S ribosome in complex with elongation factor G and fusidic acid in the post-translocational state; 16S Ribosomal RNA 4wqf DW 76 2.8 RF00005 URS00005AA258_1403831 25594181 0030533 0006412 1403831 gcccgganagcucagucgguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with elongation factor G and fusidic acid in the post-translocational state; P-site tRNA 4wqf DY 73 2.8 RF00005 URS00005AA258_1403831 25594181 0030533 0006412 1403831 gcccgganagcucagggagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<.....>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....)))).((((.........)))).....((.((.......)).))))))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with elongation factor G and fusidic acid in the post-translocational state; P-site tRNA 4wqr 13 1498 3.15 RF00177,RF01959,RF01960 URS000080E226_300852 26037619 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<........>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>....<<<<.<<<<<....>>>>>.>>>>...<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>....<<......>>...>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<...<<<.....>>>>......>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<..<.<<<<<<<........>>>>>>>>...>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(...(........)...).)))))......(((......((((((((..((...(((((((.(((((.....(((((....)))))......)))))....((((.(.(((....))).).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((.(..((((((((((......((........))..........(((((((..(...((((((((..(((((((....))))))).....(.....).....))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((.......(((.....)))......))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...((((((......(((..(((.((((....))))).))....)))......))))))......(....(((((((........)))))))....)..)..).))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Complex of 70S ribosome with tRNA-Phe and mRNA with C-A mismatch in the first position in the A-site.; 16S ribosomal RNA 4wqr 1K 76 3.15 RF00005 URS00005AA258_83333 26037619 0030533 0006412 83333 gcccggauagcucagucgguagagcaggggauugaanauccccguguccuugguucgauuccgaguccgggcacca <<<<<<...<<<<........>>>>.<<<<<<.....>>>>>>......<<<<.......>>>.>.>>>>>>.... (.(((....((............)).((((.........)))).....(.(((.......))).)..)).)).... Complex of 70S ribosome with tRNA-Phe and mRNA with C-A mismatch in the first position in the A-site.; tRNA-Phe 4wqr 2K 77 3.15 RF00005 URS000057545F_83333 26037619 0030533 0006412 83333 cgcggggnggagcagcccgguagcucgucgggnucauaacccgaagnucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Complex of 70S ribosome with tRNA-Phe and mRNA with C-A mismatch in the first position in the A-site.; tRNA-fMet 4wqr 3K 76 3.15 RF00005 URS00005AA258_83333 26037619 0030533 0006412 83333 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca ...<<<<..<<.<........>.>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>.>...... (..((((...((..........))..(((((.......))))).....((((.........))))))))..).... Complex of 70S ribosome with tRNA-Phe and mRNA with C-A mismatch in the first position in the A-site.; tRNA-Phe 4wqr 4K 14 3.15 26037619 300852 aaaaugcucaaaaa .............. .............. Complex of 70S ribosome with tRNA-Phe and mRNA with C-A mismatch in the first position in the A-site.; mRNA 4wqr 1H 2912 3.15 RF02540,RF02541,RF00002 URS0000868533_300852 26037619 0003735 0005840 300852 ggucaagaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaacggcccgcacgcgggccgaaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggauguuggcuuagaagcagccaucauuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucuugacc ..<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.....>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....<<<<<<......>>>>>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<....<<<<<......>>>>.>....>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<.....<.........>.....>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<.<<<<<<<<<...........<<.<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>.>>..>>>>>>>>>.>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<<..<<.......>>>..>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>.. ...(.((.......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((......(...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)..)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....(((............)))....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((.......(........)........)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......(.(((...(...................).......(..............).))).)...)))))))))).))..........]]].)....))))))))))...)))))))(((((((.......)))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........(((((....(......(.(((.((....)).))).)...)..............)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))..(((.......)).)...(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...)))).....)).)... Complex of 70S ribosome with tRNA-Phe and mRNA with C-A mismatch in the first position in the A-site.; 23S ribosomal RNA 4wqr 16 122 3.15 RF00001 URS00005AB4A7_300852 26037619 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga ...<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>. ...((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).)))))))))). Complex of 70S ribosome with tRNA-Phe and mRNA with C-A mismatch in the first position in the A-site.; 5S ribosomal RNA 4wqr 1G 1497 3.15 RF00177,RF01959,RF01960 URS000080E226_300852 26037619 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugg .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>....<<<....>>>...>>>>>>>>..<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<...<<<.....>>>.>.....>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>....>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.. .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((..)))))))).)))))......(((......((((((((..((...(((((((.(((((....((((.(....).)))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...(...]].).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((....((((((((((......((........))..........(((((((..(.....(..(.(...((((.(....).)))).....(((....)))...).)..)..).((.(((....(((.(.(....(((((((((....)))...(((......)))...)))))).....((((.(((((.....(...(((.....))).)......))))).....(((((....)))))........)))).....).)..))...)..)))))....)))))))...)).)))))))).(...(((((((.....(((..((..(((......)))..))....))).....)))))))......(....(((((((........)))))))....)..)....))).....(((((((..........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}. Complex of 70S ribosome with tRNA-Phe and mRNA with C-A mismatch in the first position in the A-site.; 16S ribosomal RNA 4wqr 1L 76 3.15 RF00005 URS00005AA258_83333 26037619 0030533 0006412 83333 gcccggauagcucagucgguagagcaggggauugaanauccccguguccuugguucgauuccgaguccgggcacca <<<.<<...<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>.>>.>>>.... ..(..((..(((..........))).(.((.........)).).....(..((.......))..)))..)...... Complex of 70S ribosome with tRNA-Phe and mRNA with C-A mismatch in the first position in the A-site.; tRNA-Phe 4wqr 2L 77 3.15 RF00005 URS000057545F_83333 26037619 0030533 0006412 83333 cgcggggnggagcagcccgguagcucgucgggnucauaacccgaagnucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Complex of 70S ribosome with tRNA-Phe and mRNA with C-A mismatch in the first position in the A-site.; tRNA-fMet 4wqr 3L 76 3.15 RF00005 URS00005AA258_83333 26037619 0030533 0006412 83333 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca ..<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<.........>>>>>>>>.>..... ..(((((..((((........)))).(((((.......))))).....(.(((.......))).))))).)..... Complex of 70S ribosome with tRNA-Phe and mRNA with C-A mismatch in the first position in the A-site.; tRNA-Phe 4wqr 14 2909 3.15 RF02540,RF02541,RF00002 URS0000868533_300852 26037619 0003735 0005840 300852 ggucaagaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaacggcccgcacgcgggccgaaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggauguuggcuuagaagcagccaucauuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucuugacc ...<.<<<......<<<<<<<<<<<.....[[..[[<<<<<<[[<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<....>>>>>.>>....<<<<<.....<<....>>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...(((....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>.]]...............<<....>>....]].........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....<<<............>>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<....<<<<........>>>.>....>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..((((...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.........<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<........<<<<<<<....>>>>>>.>....>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<.(((..>>>>..)))>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))))>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<.............>>>>....>>>.>>>>.......>>>>>>>...<<<.....>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>.>... .......(......((((((((((.....(((..((((((((((((......((((((.[[..[[[)))...].((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((.(..).)))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....((..............))....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((...((...(......)....))...)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[.....((((((.....(.....((..(((((((........{...(((...(...................)...........((......))...)))........))))))).))..........]]].)....)))))).)))...)))))))(((((((.......)))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((.((((((((((((.(.........(((((..(.((......(..(.((....)).)...)...)))............)))))).)))))))))))).)))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.((.((.........)).))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(...((.....))......(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...))....... Complex of 70S ribosome with tRNA-Phe and mRNA with C-A mismatch in the first position in the A-site.; 23S ribosomal RNA 4wqr 1J 122 3.15 RF00001 URS00005AB4A7_300852 26037619 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga ..<<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> ..(.(((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).))))))))).) Complex of 70S ribosome with tRNA-Phe and mRNA with C-A mismatch in the first position in the A-site.; 5S ribosomal RNA 4wqu AA 2872 2.8 RF02540,RF02541,RF00002 URS00001698E8_300852 25594181 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<.<<<<<<<...........<<<<<..<<<......<<<<<<<<<..>>>>>>>>>...>>>............>>>>>..>>>>>>>.>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((...((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....((((((((..[......))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((.(.((.(((......)))..)))..))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{..((.(..((..(((.........)))..))......(...((......)).).).))....)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((.((.(.(((.(.........((..(..(((......((((..((....))..))))...)))............)..))).))).).)).)))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((.))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with elongation factor G trapped by the antibiotic dityromycin; 23S Ribosomal RNA 4wqu AB 120 2.8 RF00001 URS000080DEE8_300852 25594181 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> (((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).))))))))))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with elongation factor G trapped by the antibiotic dityromycin; 5S Ribosomal RNA 4wqu BA 1495 2.8 RF00177,RF01959,RF01960 URS000080DFED_300852 25594181 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccucgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcggucguaacaagguagcuguaccggaaggugcggcugga .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<...>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>....<<......>>...>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<...<<<..<<<.....>>>>>>....>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>>.>>.........<<<<<<<<<....>>>>>>>>>... .....(((...[.[[[...))).((((.(((((..(((((((((....(((.(((..(((..((.((((((......)))))).)))))......(((......((((((((..((...(((((((.(((((....(((.((....)).))).....)))))....((((.(((((....))))).))))...(((.....))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((...))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....(.((.....)).).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.((((((...(...((((......(((.((......)).)))....((......)).......))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((.(..(((..(((.....))))))...).))))).....(((((....)))))........)))).....).).)))...)).))))).....))))))).[)).)))))))).(...((((((......(((..(((.((((....))))).))....)))......))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))).))...)..)..(((((((((....)))))))))}.. Crystal structure of the Thermus thermophilus 70S ribosome in complex with elongation factor G trapped by the antibiotic dityromycin; 16S Ribosomal RNA 4wqu BW 76 2.8 RF00005 URS00005AA258_1403831 25594181 0030533 0006412 1403831 gcccgganagcucagucgguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with elongation factor G trapped by the antibiotic dityromycin; P-site tRNA 4wqu BY 74 2.8 RF00005 URS00005AA258_1403831 25594181 0030533 0006412 1403831 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((......)))).((((.........)))).....(((((.......)))))))))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with elongation factor G trapped by the antibiotic dityromycin; P-site tRNA 4wqu CA 2868 2.8 RF02540,RF02541,RF00002 URS00001698E8_300852 25594181 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<.<.<<<<<<......>>>>.>>.>.>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<..>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<.<<<<<<<...........<<<<.<.<<<......<<<<<<<<<..>>>>>>>>>...>>>............>>>>>..>>>>>>>.>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...((((((((.....))))))))....{.(((((((((......(...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)..)))))).))))....(((((((((.[.....)))))))))....}.(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((()))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((......(((......))).......)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((.(.....{...(((.......((.........).)..............((......))...))).....).)))))))).))..........]]].)....))))))))))...)))))))(((((((())))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((.((.((..(......[..(((.(..(((.......((((.((....)).))))....)))..........].).))))..)).)).)))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))((((.))).....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))...)))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with elongation factor G trapped by the antibiotic dityromycin; 23S Ribosomal RNA 4wqu CB 120 2.8 RF00001 URS000080DEE8_300852 25594181 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>. .((((((((((....((((((.(....(((((((...(.....)...))))..)))...).)))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the Thermus thermophilus 70S ribosome in complex with elongation factor G trapped by the antibiotic dityromycin; 5S Ribosomal RNA 4wqu DA 1501 2.8 RF00177,RF01959,RF01960 URS000080DFED_300852 25594181 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcggucguaacaagguagcuguaccggaaggugcggcuggau .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<.<<..<<<<<<<....>>>>>>>....<<......>>...>>.>>>>>..<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<<..<<<.....>>>>>.....>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>....>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<...<<<<....>>>>...>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>>.>>...>.....<<<<<<<<<....>>>>>>>>>.... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((..((((....))))..))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((..((((((.((..(((((..((((((((((......((........))..........((.((((..(...(.((.((.....((.(......).))...(...(......)...).)).)).)).((.(((...((((.(.(....(((((((((....)))....((......))....)))))).....((((...((.(...(((..(((.....))))))....).))....(..(((((....))))).....)..)))).....).)..))...)).)))))....)))).))..[)).)))))))).(...((.((((.....(((..(...((((....))))...)....))).....))).)))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))).))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))).))...)..)..(((((((((....)))))))))}... Crystal structure of the Thermus thermophilus 70S ribosome in complex with elongation factor G trapped by the antibiotic dityromycin; 16S Ribosomal RNA 4wqu DW 76 2.8 RF00005 URS00005AA258_1403831 25594181 0030533 0006412 1403831 gcccgganagcucagucgguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((.........)))).....((.((..]....)).))))))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with elongation factor G trapped by the antibiotic dityromycin; P-site tRNA 4wqu DY 73 2.8 RF00005 URS00005AA258_1403831 25594181 0030533 0006412 1403831 gcccgganagcucagggagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<.....>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....)))).((((.........)))).....((.((.......)).))))))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with elongation factor G trapped by the antibiotic dityromycin; P-site tRNA 4wqy AA 2852 2.8 RF02540,RF02541,RF00002 URS00001698E8_300852 25594181 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<........<<<<<<..................<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>.....>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>>....<<<..>>>......>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<.<<<<<<<...........<<<<<..<<<......<<<<<.<<<..>>>.>>>>>...>>>............>>>>>..>>>>>>>.>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((..(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((.(.(...((......))....))..)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...(((......(.((((((.....(............(((((((.....{..((.(.(((..(((.........)))..))).....(...((......)).).).))....))))))))....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((..))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((.(((.(.........((.((..(((......((((...(....)...))))...)))............)).))).))).))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((.))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with elongation factor G in the post-translocational state (without fusitic acid); 23S Ribosomal RNA 4wqy AB 120 2.8 RF00001 URS000080DEE8_300852 25594181 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> (((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).))))))))))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with elongation factor G in the post-translocational state (without fusitic acid); 5S Ribosomal RNA 4wqy BA 1495 2.8 RF00177,RF01959,RF01960 URS000080DFED_300852 25594181 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccucgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcggucguaacaagguagcuguaccggaaggugcggcugga .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<..[.>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<...>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>.......]..<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>....<<<....>>>...>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<...<<<.....>>>.>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>>.>>.........<<<<<<<<<....>>>>>>>>>... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((.(......).)))).)))))......(((......((((((((..((...(((((((.(((((......(((......))).......)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((...))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((.(((...(((.(((....))).)))....((......))....))).)))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((.(..(((..(((.....))))))...).))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((..........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))).))...)..)..(((((((((....)))))))))}.. Crystal structure of the Thermus thermophilus 70S ribosome in complex with elongation factor G in the post-translocational state (without fusitic acid); 16S Ribosomal RNA 4wqy BV 13 2.8 25594181 32630 aaaaauguucuaa ............. ............. Crystal structure of the Thermus thermophilus 70S ribosome in complex with elongation factor G in the post-translocational state (without fusitic acid); mRNA 4wqy BX 76 2.8 RF00005 URS000041AF00_1403831 25594181 0030533 0006412 1403831 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with elongation factor G in the post-translocational state (without fusitic acid); P-site tRNA 4wqy CA 2848 2.8 RF02540,RF02541,RF00002 URS00001698E8_300852 25594181 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<........<<<<<<..................<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>.....>>>>>>.>>>...>>>>>>><<<<<<<<>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<.<<<<<<<...........<<<<<..<<<......<<<<<<<<<..>>>>>>>>>...>>>............>>>>>..>>>>>>>.>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...((((((((.....))))))))....{.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).))))....(((((((((.[.....)))))))))....}.(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((..))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((......(((......))).......))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...(((......(.((((((.....(............(((((((..........((..((..(((.........)))..))..........((......))...))......))))))))....))))))))))...)))))))(((((((())))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((.(((((((((.(......[..((.((...((......(((((.((....)).)))))...))...........].)).))).))))))))).))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))((((.))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with elongation factor G in the post-translocational state (without fusitic acid); 23S Ribosomal RNA 4wqy CB 120 2.8 RF00001 URS000080DEE8_300852 25594181 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the Thermus thermophilus 70S ribosome in complex with elongation factor G in the post-translocational state (without fusitic acid); 5S Ribosomal RNA 4wqy DA 1501 2.8 RF00177,RF01959,RF01960 URS000080DFED_300852 25594181 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcggucguaacaagguagcuguaccggaaggugcggcuggau .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<.<...<<<<<<<....>>>>>>>....<<......>>....>.>>>>>..<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<...<<<.....>>>.>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>....>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>>.>>...>.....<<<<<<<<<....>>>>>>>>>.... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((.(....((((((......)))))).(...((....))...)..).))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(.(((((..(((..(((.....))))))...))))).)..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))).))...)..)..(((((((((....)))))))))}... Crystal structure of the Thermus thermophilus 70S ribosome in complex with elongation factor G in the post-translocational state (without fusitic acid); 16S Ribosomal RNA 4wqy DX 76 2.8 RF00005 URS000041AF00_1403831 25594181 0030533 0006412 1403831 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with elongation factor G in the post-translocational state (without fusitic acid); P-site tRNA 4wr6 13 1498 3.05 RF00177,RF01959,RF01960 URS000080E226_300852 26037619 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<........>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>....<<......>>...>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<...<<<<....>>>>...>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(.(((.(...)..))).).)))))......(((......((((((((..((...(((((((.(((((....((((........)))).....)))))....((.(.(.(((....))).).).))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((.(.....).)).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))..........((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((((..(((((((....)))))))....((.....).)...))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((.......(((.....)))......))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))... Complex of 70S ribosome with tRNA-Tyr and mRNA with A-A mismatch in the first position in the A-site.; 16S ribosomal RNA 4wr6 1K 85 3.05 RF00005 URS00002D9DE2_83333 26037619 0030533 0006412 83333 gguggggnucccgagcngccaaagggagcagacunuanaucugccgucaucgacuucgaaggnucgaauccuucccccaccacca <<<<<<<..<<<...........>>>.<<<<<.......>>>>>.<<<...>>>...<<<<<.......>>>>>>>>>>>>.... ((..(((..(.(.....[......)).((((.........)))).(((...)))...(.(((..]....))).))))..)).... Complex of 70S ribosome with tRNA-Tyr and mRNA with A-A mismatch in the first position in the A-site.; tRNA-Tyr 4wr6 2K 77 3.05 RF00005 URS000057545F_83333 26037619 0030533 0006412 83333 cgcggggnggagcagcccggnagcucgucgggnucauaacccgaagnucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Complex of 70S ribosome with tRNA-Tyr and mRNA with A-A mismatch in the first position in the A-site.; tRNA-fMet 4wr6 3K 85 3.05 RF00005 URS00002D9DE2_83333 26037619 0030533 0006412 83333 gguggggnucccgagcngccaaagggagcagacunuanaucugccgucaucgacuucgaaggnucgaauccuucccccaccacca <<<<<<<..<<<...........>>>.<<<<<.......>>>>>.<<<...>>>...<<<<<.......>>>>>>>>>>>>.... (((((((..(((.....[.....))).((((.........))))..((...))....(((((..]....)))))))))))).... Complex of 70S ribosome with tRNA-Tyr and mRNA with A-A mismatch in the first position in the A-site.; tRNA-Tyr 4wr6 4K 15 3.05 26037619 300852 aaaaaugaacaaaaa ............... ............... Complex of 70S ribosome with tRNA-Tyr and mRNA with A-A mismatch in the first position in the A-site.; mRNA 4wr6 1H 2912 3.05 RF02540,RF02541,RF00002 URS0000868533_300852 26037619 0003735 0005840 300852 ggucaagaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaacggcccgcacgcgggccgaaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggauguuggcuuagaagcagccaucauuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucuugacc .<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<.......>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....<<<<<<......>>>>>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<........>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<.....<.........>.....>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<.<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>.>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<<<<<<<<...<<.......>>...>>>>>>>..>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<.......>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>>. ..((.(((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((......(...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)..)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....((..((......))..))....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((...((..(........)...))...)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......(((((...(....(.........)....)........................)))))...)))))))))).))..........]]].)....))))))))))...)))))))(((((((.......)))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((.((.((((((.((.(.........((.....(.(........((((((....))))))......))...............))).)).)))))).)).)))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(..((.......)).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))).)).. Complex of 70S ribosome with tRNA-Tyr and mRNA with A-A mismatch in the first position in the A-site.; 23S ribosomal RNA 4wr6 16 122 3.05 RF00001 URS00005AB4A7_300852 26037619 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga ..<<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> ...((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Complex of 70S ribosome with tRNA-Tyr and mRNA with A-A mismatch in the first position in the A-site.; 5S ribosomal RNA 4wr6 1G 1498 3.05 RF00177,RF01959,RF01960 URS0000868551_300852 26037619 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>....<<<<.<<<<<....>>>>>.>>>>...<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>....<<<....>>>...>>>>>>>>..<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<...<<<.....>>>.>.....>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>....>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((..)))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........(((.....(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((....)).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(....(((((((..(((((((....)))))))....(((....)))...))))))).).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.((((.(........(((.....))).......).)))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....((((.((..........)).))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Complex of 70S ribosome with tRNA-Tyr and mRNA with A-A mismatch in the first position in the A-site.; 16S ribosomal RNA 4wr6 1L 85 3.05 RF00005 URS00002D9DE2_83333 26037619 0030533 0006412 83333 ggugggguucccgagcggccaaagggagcagacuguaaaucugccgucaucgacuucgaagguucgaauccuucccccaccacca <<..<<<..<<<...........>>>.<<<<<.......>>>>>.<<<...>>>.....<<.........>>..>>>..>>.... ((...............[..........((((.......))))................(((..]....)).)......)).... Complex of 70S ribosome with tRNA-Tyr and mRNA with A-A mismatch in the first position in the A-site.; tRNA-Tyr 4wr6 2L 77 3.05 RF00005 URS000057545F_83333 26037619 0030533 0006412 83333 cgcggggnggagcagcccggnagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Complex of 70S ribosome with tRNA-Tyr and mRNA with A-A mismatch in the first position in the A-site.; tRNA-fMet 4wr6 3L 85 3.05 RF00005 URS00002D9DE2_83333 26037619 0030533 0006412 83333 ggugggguucccgagcggccaaagggagcagacuguaaaucugccgucaucgacuucgaagguucgaauccuucccccaccacca <<<<<<<..<<<...........>>>.<<<<<.......>>>>>.<<<...>>>...<<<<<.......>>>>>>>>>>>>.... (((..((..(((.....[.....))).(((((.......))))).............(((((..]....)))))))..))).... Complex of 70S ribosome with tRNA-Tyr and mRNA with A-A mismatch in the first position in the A-site.; tRNA-Tyr 4wr6 4L 16 3.05 26037619 300852 aaaaaaaugaacaaaa ................ ................ Complex of 70S ribosome with tRNA-Tyr and mRNA with A-A mismatch in the first position in the A-site.; mRNA 4wr6 14 2907 3.05 RF02540,RF02541,RF00002 URS0000868533_300852 26037619 0003735 0005840 300852 ggucaagaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaacggcccgcacgcgggccgaaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggauguuggcuuagaagcagccaucauuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucuugacc .<<.<<<<......<<<<<<<<<<<.....[[..[[<<<<<<[[<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<..>>>>>>.>>....<<<<<.....<......>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...(((....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>.]]...............<<....>>....]].........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....<<<<<........>>>>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<......<.<<<<<.<<...<<<.........>>>...>>.........<<......>>...>>>>>.>..>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..((((...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.........<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<.......<<<<<<<<..>>>>>>>.>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<.(((..>>>>..)))>>>>>>.............>>>>..]]>>>>.......<<<<..<<<<<<<...<<.....>>...>>>>>>>...>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))))>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<.............>>>>....>>>.>>>>.......>>>>>>>...<<<.....>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>.>>. .(.(.(((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((..)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((((((((..).))))))))....(.(((((((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((((.((((....)))).)))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....((.(..........).))....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.(((....((...(......)....))....))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((((..(.....{..((((.(((.....(.......).....))).....(...((......)).).))))....)..))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((.(((((((.((.....)))))))))......))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((.((.((((((.(.........(((((..((........(.(((((....)))))..)....))............)))))).)))))).)).))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.((((...........))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....((((((..((..]]]]..)).)))))).....)}......))))..))))))......(((((.(.((((((...((.....))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(...((.....))......(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))).).). Complex of 70S ribosome with tRNA-Tyr and mRNA with A-A mismatch in the first position in the A-site.; 23S ribosomal RNA 4wr6 1J 122 3.05 RF00001 URS00005AB4A7_300852 26037619 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga ..<<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> ..(((((((((((....((((((.(....((.((((.............))))...))...).)))).))(((.......((.(((((....))))).)).......))).))))))))))) Complex of 70S ribosome with tRNA-Tyr and mRNA with A-A mismatch in the first position in the A-site.; 5S ribosomal RNA 4wra 13 1505 3.05 RF00177,RF01959,RF01960 URS000080E226_300852 26037619 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<..........>.>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>.....<......>....>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(.(..((.(.(((...............))).).)).))......(((.......(((((((..((...(((((.(.(((((.....(((........)))......)))))....((.(.(((((....))))).).))...((((...)))).).)))))..))))))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((((..(((((((....)))))))....((.....).)...))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((.......(((.....)))......))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...((((((......(((..(((.((((....))))).))....)))......))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Complex of 70S ribosome with tRNA-Tyr and mRNA with A-A mismatch in the first position in the A-site and with antibiotic paromomycin.; 16S ribosomal RNA 4wra 1K 85 3.05 RF00005 URS00002D9DE2_562 26037619 0030533 0006412 562 ggugggguucccgagcggccaaagggagcagacunuanaucugccgucaucgacuucgaaggnucgaauccuucccccaccacca <<<<<<<..<<.............>>.<<<<<.......>>>>>.<<<...>>>...<<<<<.......>>>>>>>>>>>>.... ((..(.(..(.(...........).).((((.........)))).(.(...).)...(((((.......)))))).)..)).... Complex of 70S ribosome with tRNA-Tyr and mRNA with A-A mismatch in the first position in the A-site and with antibiotic paromomycin.; tRNA-Tyr 4wra 2K 77 3.05 RF00005 URS000057545F_562 26037619 0030533 0006412 562 cgcggggnggagcagcccgguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....((((...].....))))))))))..... Complex of 70S ribosome with tRNA-Tyr and mRNA with A-A mismatch in the first position in the A-site and with antibiotic paromomycin.; tRNA-fMet 4wra 3K 85 3.05 RF00005 URS00002D9DE2_562 26037619 0030533 0006412 562 ggugggguucccgagcggccaaagggagcagacuguaaaucugccgucaucgacuucgaagguucgaauccuucccccaccacca <<<<<<<..<<<...........>>>.<<<<<.......>>>>>.<<<...>>>...<<<<<.......>>>>>>>>>>>>.... (((((((..(((.....[.....))).((((.........))))..((...))....(((((..]....)))))))))))).... Complex of 70S ribosome with tRNA-Tyr and mRNA with A-A mismatch in the first position in the A-site and with antibiotic paromomycin.; tRNA-Tyr 4wra 4K 12 3.05 26037619 300852 aaaaugaacaaa ............ ............ Complex of 70S ribosome with tRNA-Tyr and mRNA with A-A mismatch in the first position in the A-site and with antibiotic paromomycin.; mRNA 4wra 1H 2912 3.05 RF02540,RF02541,RF00002 URS0000868544_300852 26037619 0003735 0005840 300852 ggucaagaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaacggcccgcacgcgggccgaaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggauguuggcuuagaagcagccaucauuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucuugacc .<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.....>>>>>>.>>....<<<<<.....<......>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....<<<<<<<....>>>>>>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<....<<<<........>>>.>....>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<.<<....>>.>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<<..<<.......>>>..>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>>. ..((((((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((......(...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)..)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....((((.(......).))))....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((...((...............))...)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((.(.......(((((..((...(...........)...))......(..............).)))))...).)))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((.(((((((.((.....)))))))))......))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((...........((.......(......(.(((.((....)).))).)...).................))..))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.(((.......)))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...))))))).. Complex of 70S ribosome with tRNA-Tyr and mRNA with A-A mismatch in the first position in the A-site and with antibiotic paromomycin.; 23S ribosomal RNA 4wra 16 122 3.05 RF00001 URS00005AB4A7_300852 26037619 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga ..<<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> ..(((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).))))))))))) Complex of 70S ribosome with tRNA-Tyr and mRNA with A-A mismatch in the first position in the A-site and with antibiotic paromomycin.; 5S ribosomal RNA 4wra 1G 1504 3.05 RF00177,RF01959,RF01960 URS000080E226_300852 26037619 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugg .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<.......>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>.....<......>....>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.. .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((.((...)).)))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((.(((((...))))).))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((.(..((((((((((......((........))..........(((((((..(...((((((((..(((((((....)))))))....((......))...))))))))).((.(((...((((.(.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(....(((.....)))..)...))))))).....(((((....)))))........)))).....).)..))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..).))).....(((((((..........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}. Complex of 70S ribosome with tRNA-Tyr and mRNA with A-A mismatch in the first position in the A-site and with antibiotic paromomycin.; 16S ribosomal RNA 4wra 1L 85 3.05 RF00005 URS00002D9DE2_562 26037619 0030533 0006412 562 ggugggguucccgagcggccaaagggagcagacuguaaaucugccgucaucgacuucgaagguucgaauccuucccccaccacca <<.<<<<..<<<...........>>>.<<<<<.......>>>>>.<<<...>>>...<<<<<.......>>>>>>>>>.>>.... ((..((((......)............((((.........)))).............(.(((.......))).))))..)).... Complex of 70S ribosome with tRNA-Tyr and mRNA with A-A mismatch in the first position in the A-site and with antibiotic paromomycin.; tRNA-Tyr 4wra 2L 77 3.05 RF00005 URS000057545F_562 26037619 0030533 0006412 562 cgcggggnggagcagcccgguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Complex of 70S ribosome with tRNA-Tyr and mRNA with A-A mismatch in the first position in the A-site and with antibiotic paromomycin.; tRNA-fMet 4wra 3L 85 3.05 RF00005 URS00002D9DE2_562 26037619 0030533 0006412 562 ggugggguucccgagcggccaaagggagcagacuguanaucugccgucaucgacuucgaagguucgaauccuucccccaccacca <<<<<<<..<<<...........>>>.<<<<<.......>>>>>.<<<...>>>...<<<<<.......>>>>>>>>>>>>.... (((((.(..(((.....[.....))).((((.........)))).((.....))...(((((..]....))))).)))))).... Complex of 70S ribosome with tRNA-Tyr and mRNA with A-A mismatch in the first position in the A-site and with antibiotic paromomycin.; tRNA-Tyr 4wra 4L 12 3.05 26037619 300852 aaaaaugaacaa ............ ............ Complex of 70S ribosome with tRNA-Tyr and mRNA with A-A mismatch in the first position in the A-site and with antibiotic paromomycin.; mRNA 4wra 14 2909 3.05 RF02540,RF02541,RF00002 URS0000868544_300852 26037619 0003735 0005840 300852 ggucaagaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaacggcccgcacgcgggccgaaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggauguuggcuuagaagcagccaucauuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucuugacc .<...<<<......<<<<<<<<<<<.....[[..[[<<<<<<[[<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<..>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...(((....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>.]]...............<<....>>....]].........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....<<<<..........>>>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<........>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..((((...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.........<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<.......<<<<<<<<..>>>>>>>.>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<.(((..>>>>..)))>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))))>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<.............>>>>....>>>.>>>>.......>>>>>>>..<<<<.....>>>.>...<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>...>. .(.(.(((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((......)))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((((.(((..).)).)))))....(.(((((((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))......(((..........))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((....((...(((.(((....((((..........)).))....))).)))..)).....)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((.(.......(((((..((...................))......(...((......)).).)))))...).)))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((((.......)))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((.((.((((((.(.........(((((..((........(((((((....)))))).)....))............)))))).)))))).)).))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(...((.....))......(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))).).). Complex of 70S ribosome with tRNA-Tyr and mRNA with A-A mismatch in the first position in the A-site and with antibiotic paromomycin.; 23S ribosomal RNA 4wra 1J 122 3.05 RF00001 URS00005AB4A7_300852 26037619 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga ..<<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>>> ..(((((((((((....((((((.(....(((((((...(.....)...))))..)))...).)))).))(((.......((.(((((....))))).)).......))).))))))))))) Complex of 70S ribosome with tRNA-Tyr and mRNA with A-A mismatch in the first position in the A-site and with antibiotic paromomycin.; 5S ribosomal RNA 4wro 13 1497 3.05 RF00177,RF01959,RF01960 URS000080E226_300852 26037619 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugg .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<........>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<......>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.. .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(.(((........))).).)))))......(((......((((((((..((...((((((..(((((....(((((......))))).....)))))....((((.(.(((....))).).))))...((((...))))..))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((((..(((((((....))))))).....(.....).....))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...(...(((.....))).)....))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}. Complex of 70S ribosome with tRNA-Phe and mRNA with C-A mismatch in the second position in the A-site; 16S ribosomal RNA 4wro 1L 76 3.05 RF00005 URS00005AA258_83333 26037619 0030533 0006412 83333 gcccgganagcucagncggnagagcaggggauugaanauccccgunuccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... .((((((..(((..........))).((((.........)))).....((.((.......)).))))))))..... Complex of 70S ribosome with tRNA-Phe and mRNA with C-A mismatch in the second position in the A-site; tRNA-Phe 4wro 2L 77 3.05 RF00005 URS000057545F_83333 26037619 0030533 0006412 83333 cgcggggnggagcagcccggnagcucgucgggnucauaacccgaagnucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Complex of 70S ribosome with tRNA-Phe and mRNA with C-A mismatch in the second position in the A-site; tRNA-fMet 4wro 3L 76 3.05 RF00005 URS00005AA258_83333 26037619 0030533 0006412 83333 gcccgganagcucagncggnagagcaggggauugaanauccccgunuccuugguucgauuccgaguccgggcacca .<<<<....<<<<........>>>>.<<<<<<.....>>>>>>.....<<<...........>>>..>>>>..... ..(..(...((((........)))).((((.........)))).....(((((.......))))).)..)...... Complex of 70S ribosome with tRNA-Phe and mRNA with C-A mismatch in the second position in the A-site; tRNA-Phe 4wro 14 2909 3.05 RF02540,RF02541,RF00002 URS0000868533_300852 26037619 0003735 0005840 300852 ggucaagaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaacggcccgcacgcgggccgaaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggauguuggcuuagaagcagccaucauuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucuugacc .<<.<<<<......<<<<<<<<<<<.....[[..[[<<<<<<[[<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<..>>>>>>.>>....<<<<<.....<<....>>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...(((....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>.]]...............<<....>>....]].........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....<<<<<<......>>>>>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<....<<<<<......>>>>.>....>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<......<.<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>.>..>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..((((...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.........<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<............<.<<..<<<......<<<<<<<.<..>.>>>>>>>...>>>............>>.>...>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<.(((..>>>>..)))>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))))>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<.............>>>>....>>>.>>>>.......>>>>>>>..<<<<.....>>>.>...<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>.>>. ..((.(.(......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((......)))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((((((((..).))))))))....(.(((((((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....(((............)))....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...((....(((.(((....((..((......))...))....))).)))...).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[.....((((((.....(.....((..(((((((.((.....{..(((....(.....(.......).....)...........(........)....)))....)).))))))).))..........]]].)....)))))).)))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(....(((....)))......))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((.(((((((((.(.........(((((..(((.......(.(((((....)))))..)...)))............)))))).))))))))).))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(.((.....)).)....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)).).)).. Complex of 70S ribosome with tRNA-Phe and mRNA with C-A mismatch in the second position in the A-site; 23S ribosomal RNA 4wro 1K 74 3.05 RF00005 URS00005AA258_83333 26037619 0030533 0006412 83333 gcccgganagcucagncggagagcaggggauugaanauccccgnuccuugguucgauuccgaguccgggcacca <<<<<<...<<<<.......>>>>.<<<<<<.....>>>>>>.....<<<<.......>>>.>.>>>>>>.... ((.(((...((...........)).((((.........))))....(.(((.......))).).))).)).... Complex of 70S ribosome with tRNA-Phe and mRNA with C-A mismatch in the second position in the A-site; tRNA-Phe 4wro 2K 77 3.05 RF00005 URS000057545F_83333 26037619 0030533 0006412 83333 cgcggggnggagcagcccggnagcucgucgggnucauaacccgaagnucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Complex of 70S ribosome with tRNA-Phe and mRNA with C-A mismatch in the second position in the A-site; tRNA-fMet 4wro 3K 76 3.05 RF00005 URS00005AA258_83333 26037619 0030533 0006412 83333 gcccgganagcucagncggnagagcaggggauugaanauccccgunuccuugguucgauuccgaguccgggcacca <<.<<<<....<<........>>...<<<<<<<...>>>>>>>.....<<<<<.......>>>>>>>>.>>>.... ..(..((...(((........)))..((((.........))))......((((.......)))).))...)..... Complex of 70S ribosome with tRNA-Phe and mRNA with C-A mismatch in the second position in the A-site; tRNA-Phe 4wro 4K 13 3.05 URS0000868513_300852 26037619 300852 aaaauguccaaaa ............. ............. Complex of 70S ribosome with tRNA-Phe and mRNA with C-A mismatch in the second position in the A-site; RNA (30-MER) 4wro 1H 2912 3.05 RF02540,RF02541,RF00002 URS0000868533_300852 26037619 0003735 0005840 300852 ggucaagaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaacggcccgcacgcgggccgaaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggauguuggcuuagaagcagccaucauuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucuugacc ..<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.....>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....<<<<<<......>>>>>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>>....<<<<....>>>>......>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<.<<<<<<<<<...........<<.<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>.>>..>>>>>>>>>.>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<<..<<.......>>>..>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>.. .((((((.......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((......(...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)..)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....(..((........))..)....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((...(...(........)....)...)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......(.(((..((..(((.........)))..))......(..............).))).)...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........((.((....(......(.(((.((....)).))).)...)..............)).))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(..((.......)).....(((((((((.......)))))....((((((((..((....(((.(....).)))...))...))))).)))...))))...).)))))). Complex of 70S ribosome with tRNA-Phe and mRNA with C-A mismatch in the second position in the A-site; 23S ribosomal RNA 4wro 1J 122 3.05 RF00001 URS00005AB4A7_300852 26037619 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga ..<<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> ..((.((((((((....((((((((....((.((((.............))))...))...)))))).))(((.......((.(((((....))))).)).......))).)))))))).)) Complex of 70S ribosome with tRNA-Phe and mRNA with C-A mismatch in the second position in the A-site; 5S ribosomal RNA 4wro 16 122 3.05 RF00001 URS00005AB4A7_300852 26037619 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga ...<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>. ...((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).)))))))))). Complex of 70S ribosome with tRNA-Phe and mRNA with C-A mismatch in the second position in the A-site; 5S ribosomal RNA 4wro 1G 1497 3.05 RF00177,RF01959,RF01960 URS000080E226_300852 26037619 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugg .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>....<<<<.<<<<<....>>>>>.>>>>...<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<.<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<.<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>....<<<....>>>...>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<...<<<.....>>>.>.....>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>..>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>..>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.. .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((..)))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((.(..((((((((((......((........))..........(((.(((..(....((..(((..(((((((....)))))))....(((....)))...)))..)).).((.(((...((((((.(....((.((((((....)))...(((......)))...))).)).....((((.(((((((...((..(.(.....).)))....))))))).....(((((....)))))........)))).....).).)))...)).)))))....))).)))...)).)))))))).(...(.(((((.....(((..(...((((....))))...)....))).....))))).)......(....(((((((........)))))))....)..)..).))).....(((((((..........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}. Complex of 70S ribosome with tRNA-Phe and mRNA with C-A mismatch in the second position in the A-site; 16S ribosomal RNA 4wrt R 15 2.7 URS000080E01C_11520 25409151 11520 accucugcuucugcu ............... ............... Crystal structure of Influenza B polymerase with bound vRNA promoter (form FluB2); Influenza virus polymerase vRNA promoter 3' end 4wrt V 14 2.7 URS000080E200_11520 25409151 11520 aguaguaacaagag .<<....>>..... .((....))..... Crystal structure of Influenza B polymerase with bound vRNA promoter (form FluB2); Influenza virus polymerase vRNA promoter 5' end 4wsa R 14 3.4 URS000080E01C_11520 25409151 11520 uauaccucugcuuc .............. .............. Crystal structure of Influenza B polymerase bound to the vRNA promoter (FluB1 form); Influenza B vRNA promoter 3' end 4wsa V 14 3.4 URS000080E200_11520 25409151 11520 aguaguaacaagag .<<....>>..... .((....))..... Crystal structure of Influenza B polymerase bound to the vRNA promoter (FluB1 form); Influenza B vRNA promoter 5' end 4wsb R 13 2.65 URS000080E01C_11309 25409151 11309 uauaccucugcuu ............. ............. Bat Influenza A polymerase with bound vRNA promoter; Influenza A polymerase vRNA promoter 3' end 4wsb V 16 2.65 URS000080DFE6_11309 25409151 11309 aguaguaacaagaggg .<<....>>....... .((....))....... Bat Influenza A polymerase with bound vRNA promoter; Influenza A polymerase vRNA promoter 5' end 4wsd 13 1498 2.95 RF00177,RF01959,RF01960 URS0000868551_300852 26037619 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<........>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>.....<......>....>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>.........<.<<<<<<<........>>>>>>>>.........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(.(((........))).).)))))......(((......((((((((..((...((((((..(((((.....((((......))))......)))))....((((.(((((....))))).))))...((((...))))..))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((.(((((......((((((.....))))))....))))).))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((((..(((((((....))))))).....(.....).....))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...(...(((.....))).)....)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Complex of 70S ribosome with tRNA-Phe and mRNA with C-A mismatch in the second position in the A-site and with antibiotic paromomycin.; 16S ribosomal RNA 4wsd 1K 76 2.95 RF00005 URS00005AA258_83333 26037619 0030533 0006412 83333 gcccgganagcucagucgguagagcaggggauugaanauccccguguccuuggnucgauuccgaguccgggcacca <<<<<<...<<<..........>>>.<<<<<<.....>>>>>>......<<<<.......>>>>..>>>>>>.... (((((((..((............)).((((.........)))).......(((.......)))..))))))).... Complex of 70S ribosome with tRNA-Phe and mRNA with C-A mismatch in the second position in the A-site and with antibiotic paromomycin.; tRNA-Phe 4wsd 2K 77 2.95 RF00005 URS000057545F_83333 26037619 0030533 0006412 83333 cgcggggnggagcagcccgguagcucgucgggnucauaacccgaagnucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Complex of 70S ribosome with tRNA-Phe and mRNA with C-A mismatch in the second position in the A-site and with antibiotic paromomycin.; tRNA-fMet 4wsd 3K 75 2.95 RF00005 URS00005AA258_83333 26037619 0030533 0006412 83333 gcccggauagcucagucgguagagcaggggauuaanauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (.(((((..((((........)))).((((........)))).....(((((.......)))))))))).).... Complex of 70S ribosome with tRNA-Phe and mRNA with C-A mismatch in the second position in the A-site and with antibiotic paromomycin.; tRNA-Phe 4wsd 4K 13 2.95 URS0000868513_300852 26037619 300852 aaaauguccaaaa ............. ............. Complex of 70S ribosome with tRNA-Phe and mRNA with C-A mismatch in the second position in the A-site and with antibiotic paromomycin.; mRNA 4wsd 1H 2912 2.95 RF02540,RF02541,RF00002 URS0000868533_300852 26037619 0003735 0005840 300852 ggucaagaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaacggcccgcacgcgggccgaaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggauguuggcuuagaagcagccaucauuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucuugacc ..<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.....>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....<<<<<<......>>>>>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<.....<.........>.....>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<.<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>.>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<.......>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>.. ..((..........((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((......(...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)..)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....((..............))....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((...((..(........)...))...)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......(.(((..((....(.........)....))......(..............).))).)...)))))))))).))..........]]].)....))))))))))...)))))))(((((((.......)))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((.(((((((((.((.(.........((..(....(......(.(((.((....)).))).)...)..............)..))).)).))))))))).)))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(..((.......)).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)....)).. Complex of 70S ribosome with tRNA-Phe and mRNA with C-A mismatch in the second position in the A-site and with antibiotic paromomycin.; 23S ribosomal RNA 4wsd 16 122 2.95 RF00001 URS00005AB4A7_300852 26037619 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga ...<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>. ...((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).)))))))))). Complex of 70S ribosome with tRNA-Phe and mRNA with C-A mismatch in the second position in the A-site and with antibiotic paromomycin.; 5S ribosomal RNA 4wsd 1G 1498 2.95 RF00177,RF01959,RF01960 URS0000868551_300852 26037619 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<.<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>....<<......>>...>>>>>>>>..<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<...<<<.....>>>.>.....>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>....>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>..>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((..)))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(.....(.((((..(((((.(....).)))))....(((....)))...)))).)..).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...(...(((.....)))).....))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..(...((((....))))...)....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((..........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Complex of 70S ribosome with tRNA-Phe and mRNA with C-A mismatch in the second position in the A-site and with antibiotic paromomycin.; 16S ribosomal RNA 4wsd 1L 76 2.95 RF00005 URS00005AA258_83333 26037619 0030533 0006412 83333 gcccggauagcucagucgguagagcaggggauugaanauccccguguccuuggnucgauuccgaguccgggcacca <<<<<<...<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>.>>>>>>.... (((.(((..(((..........))).((((.........)))).....(((((.......)))))))).))).... Complex of 70S ribosome with tRNA-Phe and mRNA with C-A mismatch in the second position in the A-site and with antibiotic paromomycin.; tRNA-Phe 4wsd 2L 77 2.95 RF00005 URS000057545F_83333 26037619 0030533 0006412 83333 cgcggggnggagcagcccgguagcucgucgggnucauaacccgaagnucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Complex of 70S ribosome with tRNA-Phe and mRNA with C-A mismatch in the second position in the A-site and with antibiotic paromomycin.; tRNA-fMet 4wsd 3L 76 2.95 RF00005 URS00005AA258_83333 26037619 0030533 0006412 83333 gcccgganagcucagucgguagagcaggggauugaaaauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((.(((..((((........))))..((((.......))))......(((((.......)))))))).))).... Complex of 70S ribosome with tRNA-Phe and mRNA with C-A mismatch in the second position in the A-site and with antibiotic paromomycin.; tRNA-Phe 4wsd 4L 11 2.95 26037619 300852 aaaaaugucca ........... ........... Complex of 70S ribosome with tRNA-Phe and mRNA with C-A mismatch in the second position in the A-site and with antibiotic paromomycin.; mRNA 4wsd 14 2909 2.95 RF02540,RF02541,RF00002 URS0000868533_300852 26037619 0003735 0005840 300852 ggucaagaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaacggcccgcacgcgggccgaaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggauguuggcuuagaagcagccaucauuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucuugacc .<<..<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<..>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....<<<<<<......>>>>>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<....<<<<<......>>>>.>....>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<......<.<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>.>..>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<............<.<<..<<........<<<<<<<<..>>>>>>>>.....>>............>>.>...>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<.............>>>>....>>>.>>>>.......>>>>>>>..<<<<.....>>>.>...<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>..>>. .....(((......((((((((((.....(((..((((((((((((......((((((.[[..[[[)))...].((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((......)))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((((((((..).))))))))....(.((((((((...........(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))......))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....((..............))....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((...((...............))...)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((((........{..((((...(...................).......(...(........).).)))).......))))))).))..........]]].)....))))))))))...)))))))(((((((.......)))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((.(((((((((.(.........(((.(..(((.......(.(((((....)))))..)...)))............).)))).))))))))).))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(...((.....))......(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...))))..... Complex of 70S ribosome with tRNA-Phe and mRNA with C-A mismatch in the second position in the A-site and with antibiotic paromomycin.; 23S ribosomal RNA 4wsd 1J 122 2.95 RF00001 URS00005AB4A7_300852 26037619 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga ..<<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> ..(((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).))))))))))) Complex of 70S ribosome with tRNA-Phe and mRNA with C-A mismatch in the second position in the A-site and with antibiotic paromomycin.; 5S ribosomal RNA 4wsm 13 1507 3.3 RF00177,RF01959,RF01960 URS000080E226_300852 26037619 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucaccuccu .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<........>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<.<......>.>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(.(((........))).).)))))......(((......((((((((..((...(((((((.(((((....((((........)))).....)))))....((...(.(((....))).)...))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((((..((((((......)))))).................))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.((((.((...(...(((.....)))).....)).))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...((((((......(((..(((.((((....))))).))....)))......))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Complex of 70S ribosome with tRNA-Leu and mRNA with G-U mismatch in the first position in the A- and P-sites; 16S ribosomal RNA 4wsm 1K 87 3.3 RF00005 URS00004630EA_83333 26037619 0030533 0006412 83333 gccgaggugguggaauugguagacacgcuaccuugagnugguagugcccaauagggcuuacgggnucaagucccguccucgguacca <<<<<<<..<<.............>><<<<<<.......>>>>>><<<<....>>>>..<<<<<.......>>>>>>>>>>>>.... (((((((...(.............)..(((((.......))))).((........))..(((((.......)))))))))))).... Complex of 70S ribosome with tRNA-Leu and mRNA with G-U mismatch in the first position in the A- and P-sites; tRNA-Leu 4wsm 2K 79 3.3 RF00005 URS00004630EA_83333 26037619 0030533 0006412 83333 gccgaggugguggaaunnguagacacgcuaccuugagnugguagugcgcuuacgggnucaagucccguccucgguacca <<<<<<<..<<<...........>>><<<<<<.......>>>>>>......<<<<<.......>>>>>>>>>>>>.... .((((((..(((.....[.....))).(((((.......))))).......(((((..]....)))))))))))..... Complex of 70S ribosome with tRNA-Leu and mRNA with G-U mismatch in the first position in the A- and P-sites; tRNA-Leu 4wsm 3K 77 3.3 RF00005 URS00004630EA_83333 26037619 0030533 0006412 83333 gccgaggugguggaauugguagacacgcuaccuugaggugguagugcuuacggguucaagucccguccucgguacca <<<<<<<..<<.............>>.<<<<<.......>>>>>......<<<<.......>>>>.>>>>>>>.... (((((((....(.....[.....)...(((((.......))))).....((.((..]....)).))))))))).... Complex of 70S ribosome with tRNA-Leu and mRNA with G-U mismatch in the first position in the A- and P-sites; tRNA-Leu 4wsm 4K 16 3.3 26037619 300852 aggagguuuuuuuuuu ................ ................ Complex of 70S ribosome with tRNA-Leu and mRNA with G-U mismatch in the first position in the A- and P-sites; mRNA 4wsm 1H 2912 3.3 RF02540,RF02541,RF00002 URS0000868533_300852 26037619 0003735 0005840 300852 ggucaagaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaacggcccgcacgcgggccgaaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggauguuggcuuagaagcagccaucauuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucuugacc <<.<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<[[<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.....>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...(((....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>.]]...............<<....>>....]].........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....<<<<<<......>>>>>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<..<........>...>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<..<<....<...........>....>>.........<<......>>....>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..((((...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.........<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<.<<<<<<<<<...........<<.<<..<<<<.....<<<<<<<<....>>>>>>>>..>>>>............>>.>>..>>>>>>>>>.>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<.(((..>>>>..)))>>>>>>.............>>>>..]]>>>>.......<<<<.<<<<<<<<...<<.......>>...>>>>>>>..>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))))>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<.......>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>.>> .(...(((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((.((((.....)))).)))....(.(((((((((......(...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)..)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....((.((........)).))....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((...((..(........)...))...)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......(((((...............................(..............).)))))...)))))))))).))..........]]].)....))))))))))...)))))))(((((((.......)))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((.(((((((((.((.(.........((.......(......(.(...((....))...).)...).................))).)).))))))))).)))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(..................(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...))))...). Complex of 70S ribosome with tRNA-Leu and mRNA with G-U mismatch in the first position in the A- and P-sites; 23S ribosomal RNA 4wsm 16 122 3.3 RF00001 URS00005AB4A7_300852 26037619 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga ...<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>. ...((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).)))))))))). Complex of 70S ribosome with tRNA-Leu and mRNA with G-U mismatch in the first position in the A- and P-sites; 5S ribosomal RNA 4wsm 1G 1513 3.3 RF00177,RF01959,RF01960 URS000080E226_300852 26037619 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucaccuccuuu .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<<..>>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<.<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>....<<......>>...>>>>>>>>..<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<...<<<.....>>>>......>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>....>>>>>>>...>..>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.............. .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((.(((...))).))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(.....((.(((..((((.(......).))))...(((......)))..))).))..).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.((((.((.......(((.....)))......)).)))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((..........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}............. Complex of 70S ribosome with tRNA-Leu and mRNA with G-U mismatch in the first position in the A- and P-sites; 16S ribosomal RNA 4wsm 1L 87 3.3 RF00005 URS00004630EA_83333 26037619 0030533 0006412 83333 gccgaggugguggaauugguagacacgcuaccuugagnugguagugcccaauagggcuuacgggnucaagucccguccucgguacca <<<<<<<..<<<...........>>><<<<<<.......>>>>>><<<......>>>..<<<<<.......>>>>>>>>>>>>.... (((((.(..(((...........))).(((((.......)))))....(....).....(((((.......)))))).))))).... Complex of 70S ribosome with tRNA-Leu and mRNA with G-U mismatch in the first position in the A- and P-sites; tRNA-Leu 4wsm 2L 80 3.3 RF00005 URS00004630EA_83333 26037619 0030533 0006412 83333 gccgaggugguggaaunnguagacacgcuaccuugagnugguagugccgcuuacgggnucaagucccguccucgguacca <<<<<<<..<<<...........>>><<<<<<.......>>>>>>.......<<<<<.......>>>>>>>>>>>>.... .((((((..(((.....[.....))).(((((.......)))))........(((((..]....)))))))))))..... Complex of 70S ribosome with tRNA-Leu and mRNA with G-U mismatch in the first position in the A- and P-sites; tRNA-Leu 4wsm 3L 75 3.3 RF00005 URS00004630EA_83333 26037619 0030533 0006412 83333 gccgaggugguggaauuggugacacgcuaccuugaggugguagucuuacggguucaagucccguccucgguacca <<<<<<<..<<<..........>>>.<<<<<.......>>>>>....<<<<<.......>>>>>>>>>>>>.... (((((((..(.(..........).)..(((.........))).....(((((.......)))))))))))).... Complex of 70S ribosome with tRNA-Leu and mRNA with G-U mismatch in the first position in the A- and P-sites; tRNA-Leu 4wsm 4L 21 3.3 26037619 300852 caaggagguuuuuuuuuuuuu ..................... ..................... Complex of 70S ribosome with tRNA-Leu and mRNA with G-U mismatch in the first position in the A- and P-sites; mRNA 4wsm 14 2909 3.3 RF02540,RF02541,RF00002 URS0000868533_300852 26037619 0003735 0005840 300852 ggucaagaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaacggcccgcacgcgggccgaaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggauguuggcuuagaagcagccaucauuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucuugacc .<<<.<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<..>>>>>>.>>....<<<<<.....<......>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<.....<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>.>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....<<<<..........>>>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<........>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<......<.<<<<<.<<.....................>>.........<........>...>>>>>.>..>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<.....<.<.......<.<<<<<<..>>>>>>.>....>.>...............>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<.............>>>>....>>>.>>>>.......>>>>>>>....<.......>......<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>.>>>. ..............((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((..)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((((((((..).))))))))....(.((((((((......((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))..))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))......((............)).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((...((...............))...)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((((..(.....{..((((...(...................)...........(........)...))))....)..))))))).))..........]]].)....))))))))))...)))))))((((((.........))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((.(((((.(((............(...............(..((((....))))...).....................)...))).))))).))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(...(.......)......(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))...)........ Complex of 70S ribosome with tRNA-Leu and mRNA with G-U mismatch in the first position in the A- and P-sites; 23S ribosomal RNA 4wsm 1J 122 3.3 RF00001 URS00005AB4A7_300852 26037619 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga ..<<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> ..(((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).))))))))))) Complex of 70S ribosome with tRNA-Leu and mRNA with G-U mismatch in the first position in the A- and P-sites; 5S ribosomal RNA 4wt1 13 1498 3.05 RF00177,RF01959,RF01960 URS0000868551_300852 26037619 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<........>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>.....<......>....>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<..<.<<<<<<<........>>>>>>>>...>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(.(((........))).).)))))......(((......((((((((..((...(((((...(((((.....((((......))))......)))))....((((.(.(((....))).).))))...((((...))))...)))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(.(((....)))..))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((.(((...))).))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((((..(((((((....))))))).....(.....).....))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((.......(.(.....).)......))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...((((((......(((..((..((((....))))..))....)))......))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Complex of 70S ribosome with tRNA-Phe and mRNA with A-A mismatch in the second position in the A-site; 16S ribosomal RNA 4wt1 1K 76 3.05 RF00005 URS00005AA258_83333 26037619 0030533 0006412 83333 gcccgganagcucagucgguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<...<<<..........>>>.<<<<<<.....>>>>>>......<<<<.......>>>.>.>>>>>>.... ((((((...((............)).((((.........)))).....(((((.......))))).)))))).... Complex of 70S ribosome with tRNA-Phe and mRNA with A-A mismatch in the second position in the A-site; tRNA-Phe 4wt1 2K 77 3.05 RF00005 URS000057545F_83333 26037619 0030533 0006412 83333 cgcggggnggagcagcccgguagcucgucgggnucauaacccgaagnucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Complex of 70S ribosome with tRNA-Phe and mRNA with A-A mismatch in the second position in the A-site; tRNA-fMet 4wt1 3K 76 3.05 RF00005 URS00005AA258_83333 26037619 0030533 0006412 83333 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca .<<<<<...<<<<........>>>>.<<<<<<.....>>>>>>......<<<<.......>>>>..>>>>>..... ....(.(..((((........)))).((((.........))))......(.((.......)).).).)........ Complex of 70S ribosome with tRNA-Phe and mRNA with A-A mismatch in the second position in the A-site; tRNA-Phe 4wt1 4K 13 3.05 26037619 300852 aaaauguacaaaa ............. ............. Complex of 70S ribosome with tRNA-Phe and mRNA with A-A mismatch in the second position in the A-site; mRNA 4wt1 1H 2912 3.05 RF02540,RF02541,RF00002 URS0000868533_300852 26037619 0003735 0005840 300852 ggucaagaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaacggcccgcacgcgggccgaaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggauguuggcuuagaagcagccaucauuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucuugacc ..<<<<<<......<<<<<<<<<<<.....<<.<<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.....>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>>..............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....<<<<<<......>>>>>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<....<<<<<......>>>>.>....>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<.<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>.>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<<..<<.......>>>..>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>.. ...((((.......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((.(.....).))))))....(.(((((((((......(...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)..)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....(((.(........).)))....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((.......(........)........)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......(((((..((..(.............)..))......(..............).)))))...)))))))))).))..........]]].)....))))))))))...)))))))(((((((.......)))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((.((((((((((((.(.........((..(...((......(.(((.((....)).))).)...)).............)..))).)))))))))))).)))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(..((.......)).....(((((((((.......)))))....((((((((..((....(((.(....).)))...))...))))).)))...))))...).))))... Complex of 70S ribosome with tRNA-Phe and mRNA with A-A mismatch in the second position in the A-site; 23S ribosomal RNA 4wt1 16 122 3.05 RF00001 URS00005AB4A7_300852 26037619 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga ...<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>. ...((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).)))))))))). Complex of 70S ribosome with tRNA-Phe and mRNA with A-A mismatch in the second position in the A-site; 5S ribosomal RNA 4wt1 1G 1497 3.05 RF00177,RF01959,RF01960 URS0000868551_300852 26037619 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugg .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]..<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<......>>>>>>....<<......>>...>>>>>>>>..<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<...<<<.....>>>.>.....>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>....>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>..........<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>.. .....((((..[..[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((..)))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((.(((((...))))).))))...((..]])).....)))))))))).(((......((((....))))....)))...]]..](((((.(((((((.((..(((.(..((((((((((......((........))..........((.((((..(.....(..(((..(((((((....)))))))....(.(....).)...)))..)..).((.(((...((((((......((.((((((....)))...(((......)))...))).)).....((((.((((((...(....(((.....)))..)....)))))).....(((((....)))))........)))).......).)))...)).)))))....)))).))...)).)))))))).(...(((((((.....(((..(...((((....))))...)....))).....)))))))......(....(((((((........)))))))....)..)..).))).....(((((((..........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}. Complex of 70S ribosome with tRNA-Phe and mRNA with A-A mismatch in the second position in the A-site; 16S ribosomal RNA 4wt1 1L 76 3.05 RF00005 URS00005AA258_83333 26037619 0030533 0006412 83333 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<.<<...<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>.>>.>>>.... .((.(((..(((..........))).(((((.......))))).....(((((.......)))))))).))..... Complex of 70S ribosome with tRNA-Phe and mRNA with A-A mismatch in the second position in the A-site; tRNA-Phe 4wt1 2L 77 3.05 RF00005 URS000057545F_83333 26037619 0030533 0006412 83333 cgcggggnggagcagcccgguagcucgucgggnucauaacccgaagnucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Complex of 70S ribosome with tRNA-Phe and mRNA with A-A mismatch in the second position in the A-site; tRNA-fMet 4wt1 3L 76 3.05 RF00005 URS00005AA258_83333 26037619 0030533 0006412 83333 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca ..<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<.........>>>>>>>>>...... ..((.((..((((........)))).(((((.......))))).....(((((.......))))))).))...... Complex of 70S ribosome with tRNA-Phe and mRNA with A-A mismatch in the second position in the A-site; tRNA-Phe 4wt1 14 2909 3.05 RF02540,RF02541,RF00002 URS0000868533_300852 26037619 0003735 0005840 300852 ggucaagaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaacggcccgcacgcgggccgaaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggauguuggcuuagaagcagccaucauuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucuugacc .<<<.<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<..>>>>>>.>>....<<<<<.....<......>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<.....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>.>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....<<<<..........>>>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<....<<<<<......>>>>.>....>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<......<.<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>.>..>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<.<<..<<........<<<<<<<<..>>>>>>>.>....>>............>>.>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<.............>>>>....>>>.>>>>.......>>>>>>>...................<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>.>>>. ..(..(.(......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((......)))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((((((((..).))))))))....(.(((((((((......(...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)..)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....((..............))....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.(.(....((...(......)....))....).).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{..((((..((...................))......(...(........).).))))....)))))))))).))..........]]].)....))))))))))...)))))))(((((((.......)))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((..(((((((((.(..........((((..(((.......(..((((....))))...)...)))............)))).).)))))))))..)))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.((((...........))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[....((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....))))))(.....(.....).......(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)).)..).. Complex of 70S ribosome with tRNA-Phe and mRNA with A-A mismatch in the second position in the A-site; 23S ribosomal RNA 4wt1 1J 122 3.05 RF00001 URS00005AB4A7_300852 26037619 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga ...<<<<<.<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>.>>>>>. ...(.((((((((....((((((((....(((((((.............))))..)))...)))))).)).((.......((.(((((....))))).)).......))..)))))))).). Complex of 70S ribosome with tRNA-Phe and mRNA with A-A mismatch in the second position in the A-site; 5S ribosomal RNA 4wt8 Ab 1504 3.4 RF00177,RF01959,RF01960 URS000080E260_300852 25562208 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<.........>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<.....<<<<<<<....>>>>>>>....<<.....>>.......>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<....<<.....>>.>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<<..>>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((.(((.........))).)))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((.(..((((((((((......((........))..........(((((((..(...(((((......((.(((....))).)).....................)))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...(..............).....)))))))..(..(((.(....).))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((...(..((((....))))..).....))).....)))))))......(....(((((((........)))))))....)..)..).))).....(((((((..........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Crystal Structure of bactobolin A bound to 70S ribosome-tRNA complex; RNA (1504-MER) 4wt8 B2 10 3.4 25562208 300852 aaaauguuca .......... .......... Crystal Structure of bactobolin A bound to 70S ribosome-tRNA complex; mRNA 4wt8 Bb 1504 3.4 RF00177,RF01959,RF01960 URS000080E260_300852 25562208 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<.........>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>.....<......>.....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<....<<.....>>.>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<<..>>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((.(((.........))).)))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((......((.(((....))).)).....................)))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...(..............).....)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((...(..((((....))))..).....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((..........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Crystal Structure of bactobolin A bound to 70S ribosome-tRNA complex; RNA (1504-MER) 4wt8 C2 75 3.4 RF00005 URS00005AA258_300852 25562208 0030533 0006412 300852 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacc <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>... (.(((((....................((((.......))))......(((((.......))))))))).))... Crystal Structure of bactobolin A bound to 70S ribosome-tRNA complex; A site tNA, E site tNA 4wt8 C3 76 3.4 RF00005 URS00005AA258_300852 25562208 0030533 0006412 300852 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((....((((........)))).((((.........)))).....(.((.........)).)..))))).... Crystal Structure of bactobolin A bound to 70S ribosome-tRNA complex; A site tNA, E site tNA 4wt8 C4 77 3.4 RF00005 URS000041AF00_300852 25562208 0030533 0006412 300852 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .(.((((..((((......[..)))).(((((.......))))).....(((((..]....))))))))).)..... Crystal Structure of bactobolin A bound to 70S ribosome-tRNA complex; P site trNA 4wt8 C1 2807 3.4 RF02540,RF02541,RF00002 URS000080E136_300852 25562208 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucgggggcccucggccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccagucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<..>>>>>>.>>....<<<<<.....<<....>>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>.....<<<<<<<<...<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>..>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<...<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<....<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.....>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<..................>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...........>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<.........>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> .........((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((....))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((((((((..).))))))))....(((((((((....(...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)...))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((((((((....)))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))..)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((.(.((((.(......).)).)))..)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((((((......{...........))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.((...{{....))))))(((...((((((((((.(((((.((.....))))))).).....)))))))))..)))(...........))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((((.......)))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((((.((((...........(((((..(((......((((((((....))))))))...)))............)))))..)))).)))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))...(.........).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....... Crystal Structure of bactobolin A bound to 70S ribosome-tRNA complex; 23S rRNA (2899-MER) 4wt8 Cs 119 3.4 RF00001 URS000080DE2B_300852 25562208 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>> .((((((((((....(((((.((....(((((((...(.....)...))))..)))...)).))).))(((.......((.(((((....))))).)).......))).)))))))))) Crystal Structure of bactobolin A bound to 70S ribosome-tRNA complex; 5S rRNA (119-MER) 4wt8 D2 20 3.4 URS000080E22B_308052 25562208 308052 auccccguguccuugguucg .................... .................... Crystal Structure of bactobolin A bound to 70S ribosome-tRNA complex; tRNA (5'-D(*AP*UP*CP*CP*CP*CP*GP*UP*GP*UP*CP*CP*UP*UP*GP*GP*UP*UP*CP*G)-3') 4wt8 D3 76 3.4 RF00005 URS00005AA258_300852 25562208 0030533 0006412 300852 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((.........)))).......(((..]....)))..))))))).... Crystal Structure of bactobolin A bound to 70S ribosome-tRNA complex; A site tNA, E site tNA 4wt8 D4 76 3.4 RF00005 URS00002905B5_308052 25562208 0030533 0006412 308052 gcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... (((((...((((......[..)))).(((((.......))))).....(((((..]....))))).)))))..... Crystal Structure of bactobolin A bound to 70S ribosome-tRNA complex; tRNA (76-MER) 4wt8 Ds 119 3.4 RF00001 URS000080DE2B_300852 25562208 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<<....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>> .((((((((((....(((((.((....(((((((...(.....)...))))..)))...)).))).))(((.......((.(((((....))))).)).......))).)))))))))) Crystal Structure of bactobolin A bound to 70S ribosome-tRNA complex; 5S rRNA (119-MER) 4wt8 D1 2807 3.4 RF02540,RF02541,RF00002 URS000080E136_300852 25562208 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucgggggcccucggccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccagucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<..>>>>>>.>>....<<<<<.....<<....>>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>.....<<<<<<<<...<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>..>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<...<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<....<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.....>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<....>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...........>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<.........>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> .........((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((....))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....((((((((....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))...)))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((((((((....)))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))..)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((.(.(((..(......)..).)))..)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((((((......{...........))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.((...{{....))))))(((...((((((((((.(((((.((.....))))))).).....)))))))))..)))(...........))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((((.......)))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((((.((((...........(((((..(((.......(.((.((....)).)).)....)))............)))))..)))).)))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))...(.........).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....... Crystal Structure of bactobolin A bound to 70S ribosome-tRNA complex; 23S rRNA (2899-MER) 4wt8 DV 55 3.4 RF00005 URS000080DF95_308052 25562208 0030533 0006412 308052 gcccggauagcucagucgguagagcaggggauugaaaauuccgaguccgggcacc <<<<<<<..<<<<........>>>>....................>>>>>>>... ...((((..((............))....................))))...... Crystal Structure of bactobolin A bound to 70S ribosome-tRNA complex; DNA (55-MER) 4wu1 13 1501 3.2 RF00177,RF01959,RF01960 URS000080E226_300852 26037619 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggcuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<.....>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>....<<<<.<<<<<....>>>>>.>>>>...<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<......>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<.<.<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(.(((.(.....).))).).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((.(.(.(((....))).).).))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((.(..((((((((((......((........))..........(.(((((..(...((((.(((...((.(.(....).).)).....(((....)))...))).))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...(...(((.....)))).....))))))).....(((((....)))))........)))).....).).)))...)).)))))....))))).)..[)).)))))))).(...(((((((.....(((..((..(.((....)).)..))....))).....)))))))......(....(((((((........)))))))....)..)..).))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Complex of 70S ribosome with tRNA-Tyr and mRNA with G-U mismatch in the second position in the P-site; 16S ribosomal RNA 4wu1 2K 82 3.2 RF00005 URS00002D9DE2_562 26037619 0030533 0006412 562 gguggggnucccgagngccaaagggagcagacunuanaucugccgucagacuucgaaggnucgaauccuucccccaccacca <<<<<<<..<<<..........>>>.<<<<<.......>>>>>.<<...>>...<<<<<.......>>>>>>>>>>>>.... (((((((..(((....[.....))).((((.........))))...(.).....(((((..]....)))))))))))).... Complex of 70S ribosome with tRNA-Tyr and mRNA with G-U mismatch in the second position in the P-site; tRNA-Tyr 4wu1 3K 85 3.2 RF00005 URS00002D9DE2_562 26037619 0030533 0006412 562 gguggggnucccgagcngccaaagggagcagacunuanaucugccgucaucgacuucgaaggnucgaauccuucccccaccacca <<<<<<<..<<<...........>>>.<<<<<.......>>>>>.<<<...>>>...<<<<<.......>>>>>>>>>>>>.... (((((((...((.....[..[..))..((((.........)))).(((...)))]..(((((..]....)))))))))))).... Complex of 70S ribosome with tRNA-Tyr and mRNA with G-U mismatch in the second position in the P-site; tRNA-Tyr 4wu1 4K 11 3.2 26037619 300852 aaaaugcaaaa ........... ........... Complex of 70S ribosome with tRNA-Tyr and mRNA with G-U mismatch in the second position in the P-site; mRNA 4wu1 1H 2912 3.2 RF02540,RF02541,RF00002 URS0000868533_300852 26037619 0003735 0005840 300852 ggucaagaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaacggcccgcacgcgggccgaaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggauguuggcuuagaagcagccaucauuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucuugacc <<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.....>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....<<<<.<.......>>>>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<..<<......>>...>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.......<<.........>>...............<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<.......>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>>> .....(((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((.(.....).))))))....(.(((((((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....((((..........))))....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((.(.(((.((......)))..)))..)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......(((((...............................(..............).)))))...)))))))))).))..........]]].)....))))))))))...)))))))(((((((.......)))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...(((.((((((((((((.((.....))))))))).....))))).)))..)))(...(((......))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........((.((..(((.......((((.((....)).))))....)))............)).))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(..(.........).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...))))..... Complex of 70S ribosome with tRNA-Tyr and mRNA with G-U mismatch in the second position in the P-site; 23S ribosomal RNA 4wu1 16 122 3.2 RF00001 URS00005AB4A7_300852 26037619 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga ...<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>. ...((((((((((....((((((.(....(((((((...(.....)...))))..)))...).)))).))(((.......((.(((((....))))).)).......))).)))))))))). Complex of 70S ribosome with tRNA-Tyr and mRNA with G-U mismatch in the second position in the P-site; 5S ribosomal RNA 4wu1 1G 1504 3.2 RF00177,RF01959,RF01960 URS0000868551_300852 26037619 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<<..>>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<...<<<<<<....>>>>>>....<<<......>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<...<<<.....>>>.>.....>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((())))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((.(.((((((((((......((((((.....))))))....))))))))..))).)))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(....((..(.(..(((((........)))))...((((....))))..).)..)).).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((.......(((.....)))......)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(.....((((((........)))))).....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Complex of 70S ribosome with tRNA-Tyr and mRNA with G-U mismatch in the second position in the P-site; 16S ribosomal RNA 4wu1 2L 78 3.2 RF00005 URS00002D9DE2_562 26037619 0030533 0006412 562 gguggggnucccgagngccaaagggagcagacunuanaucugccgucuucgaaggnucgaauccuucccccaccacca <<<<<<<..<<<..........>>>.<<<<<.......>>>>>.......<<<<<.......>>>>>>>>>>>>.... (((((((...(.....[......)..((((.........)))).......(((((..]....)))))))))))).... Complex of 70S ribosome with tRNA-Tyr and mRNA with G-U mismatch in the second position in the P-site; tRNA-Tyr 4wu1 3L 85 3.2 RF00005 URS00002D9DE2_562 26037619 0030533 0006412 562 gguggggnucccgagcngccaaagggagcagacunuanaucugccgucaucgacuucgaaggnucgaauccuucccccaccacca <<<<<<<..<<<...........>>>.<<<<<.......>>>>>.<<<...>>>...<<<<<.......>>>>>>>>>>>>.... (((((((..(((...........))).((((.........)))).............(((((.......)))))))))))).... Complex of 70S ribosome with tRNA-Tyr and mRNA with G-U mismatch in the second position in the P-site; tRNA-Tyr 4wu1 14 2909 3.2 RF02540,RF02541,RF00002 URS0000868533_300852 26037619 0003735 0005840 300852 ggucaagaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaacggcccgcacgcgggccgaaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggauguuggcuuagaagcagccaucauuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucuugacc .<<..<<.......<<<<<<<<<<<.....[[..[[<<<<<<[[<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<..>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...(((....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>.]]...............<<....>>....]].........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....<<<<..........>>>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<........>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<.....................>>.........<........>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..((((...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.........<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<.....<<<......<<<<<<<<....>>>>>>>>...>>>...............>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<.(((..>>>>..)))>>>>>>.............>>>>..]]>>>>.......<<<<.<<<<<<<<...<<.......>>...>>>>>>>..>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))))>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<.......>>.>...<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>......>>.>>. ..............((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((..)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((((((((..).))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....((((..........))))....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((....[((..........)].)....)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[.....((((((.....(.....((..((((((((((.....{.((((....(...(.(.......).)...).......(..............)..))))...)))))))))).))..........]]].)....)))))).)))...)))))))(((((((.......)))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((..(((((((((.(.........((.(...(((.......((.((((....)))).).)...))).............).))).)))))))))..)))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....((((((..((..]]]]..)).)))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(...........)....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)........ Complex of 70S ribosome with tRNA-Tyr and mRNA with G-U mismatch in the second position in the P-site; 23S ribosomal RNA 4wu1 1J 122 3.2 RF00001 URS00005AB4A7_300852 26037619 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga ..<<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> ...((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).)))))))))). Complex of 70S ribosome with tRNA-Tyr and mRNA with G-U mismatch in the second position in the P-site; 5S ribosomal RNA 4www RA 2854 3.1 RF02540,RF02541 URS00004B0F34_511145 20855725 0003735 0005840 511145 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauggaaguguggacgccagucugcauggcuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<.>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<<..<<<.........>>>..>>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<..<<....>>..>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<.....<<<<<<<......>>>>>>>....>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((((((.)))).))...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]]((((((((((.((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...)).....)))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((((.....(((((((......)))))))....)))).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Crystal structure of the E. coli ribosome bound to CEM-101; 23S rRNA 4www RB 118 3.1 RF00001 URS0000366A67_511145 20855725 0003735 0005840 511145 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))). Crystal structure of the E. coli ribosome bound to CEM-101; 5S rRNA 4www QA 1533 3.1 RF00177,RF01959,RF01960 URS000080E246_511145 20855725 0003735 0005840 511145 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggauca .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<........>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<.<.......>>>.>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((.((..)).))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((.(.......))).)))).....)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.(((((((.((......((((((.....))))))....)).)))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))...((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..((.......))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Crystal structure of the E. coli ribosome bound to CEM-101; 16S rRNA 4www XA 1530 3.1 RF00177,RF01959,RF01960 URS000080E246_511145 20855725 0003735 0005840 511145 ugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggauca ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<......>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<...<....>.>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<.<.......>>>.>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((((((.(..).)))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(...((.((((.(.......))).)).).)...)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((..(((((((....)))))))...((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....))))))))..)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Crystal structure of the E. coli ribosome bound to CEM-101; 16S rRNA 4www YA 2841 3.1 RF02540,RF02541 URS00004B0F34_511145 20855725 0003735 0005840 511145 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaacaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauggaaguguggacgccagucugcauggcuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<........>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<.......>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<<..<<<.........>>>..>>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.......<<<<<..<<....>>...>>>>>.......>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<.....<<<<<<<......>>>>>>>....>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<<...>>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...(((..((((......(((((((((((((.(((...(((((......)))))[[(...).((......]].))...)))...)))))))))))))...))))........((((.(((..[......))).))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((...(((((((((.(...(((...(((.((((.......)))).)))..)).)...).)))))).)))...))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.......(((((.(((...((.........))...))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((..((...(((...(((....)))...)))...))...((.((........)).))]](((((((((((((...((((....((((..(((..((((((((((.....{{{....)))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((((((((..((((.(...(((((((......)))))))..).))))..))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...((((...........)))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.((((((...))))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Crystal structure of the E. coli ribosome bound to CEM-101; 23S rRNA 4www YB 117 3.1 RF00001 URS0000366A67_511145 20855725 0003735 0005840 511145 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggc <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>> (((((((((.....(.((((((....(((((((...(.....)...))))..)))...))))))..).((.......((((((((...)))))))).......))...))))))))) Crystal structure of the E. coli ribosome bound to CEM-101; 5S rRNA 4wzd 13 1499 3.1 RF00177,RF01959,RF01960 URS0000868551_300852 26037619 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggcuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<....>.>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<..[.>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>.......]..<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<......>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<...<<<.....>>>>......>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<...<<<<....>>>>...>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((...(((.(.....).)))...)))))......(((......((((((((..((...(((((((.(((((....((.(((....))).)).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...((((.(((...((.(((....))).)).......(....).....))).))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.((((((....(...(((.....))))......))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Complex of 70S ribosome with cognate tRNA-Tyr in the P-site; 16S ribosomal RNA 4wzd 2K 82 3.1 RF00005 URS00002D9DE2_562 26037619 0030533 0006412 562 gguggggnucccgagngccaaagggagcagacunuanaucugccgucagacuucgaaggnucgaauccuucccccaccacca <<<<<<<..<<<..........>>>.<<<<<.......>>>>>.<<...>>...<<<<<.......>>>>>>>>>>>>.... .((((((..(((....[.....))).((((.........)))).(.(.).)...(((((..]....)))))))))))..... Complex of 70S ribosome with cognate tRNA-Tyr in the P-site; tRNA-Tyr 4wzd 3K 85 3.1 RF00005 URS00002D9DE2_562 26037619 0030533 0006412 562 gguggggnucccgagcngccaaagggagcagacunuanaucugccgucaucgacuucgaaggnucgaauccuucccccaccacca <<<<<<<..<<<...........>>>.<<<<<.......>>>>>.<<<...>>>...<<<<<.......>>>>>>>>>>>>.... (((((((..(((.....[..[..))).((((.........)))).(((...)))]..(((((..]....)))))))))))).... Complex of 70S ribosome with cognate tRNA-Tyr in the P-site; tRNA-Tyr 4wzd 4K 16 3.1 26037619 300852 gguaaaauacaaaaaa ................ ................ Complex of 70S ribosome with cognate tRNA-Tyr in the P-site; mRNA 4wzd 1H 2912 3.1 RF02540,RF02541,RF00002 URS0000868533_300852 26037619 0003735 0005840 300852 ggucaagaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaacggcccgcacgcgggccgaaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggauguuggcuuagaagcagccaucauuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucuugacc <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<[[<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.....>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...(((....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>.]]...............<<....>>....]].........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....<<<<<<......>>>>>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<........>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.......<<.........>>...............<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..((((...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.........<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<.(((..>>>>..)))>>>>>>.............>>>>..]]>>>>.......<<<<.<<<<<<<<...<<.......>>...>>>>>>>..>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))))>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<.......>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>>> (....(((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....(((((........)))))....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((...(((.((......)))..))...)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......(((((...............................(..............).)))))...)))))))))).))..........]]].)....))))))))))...)))))))(((((((.......)))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........(((((..(((........(((.((....)).))).....)))............)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....((((((..((..]]]]..)).)))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(..((.......)).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...))))....) Complex of 70S ribosome with cognate tRNA-Tyr in the P-site; 23S ribosomal RNA 4wzd 16 122 3.1 RF00001 URS00005AB4A7_300852 26037619 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga ...<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>. ...((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).)))))))))). Complex of 70S ribosome with cognate tRNA-Tyr in the P-site; 5S ribosomal RNA 4wzd 1G 1503 3.1 RF00177,RF01959,RF01960 URS0000868551_300852 26037619 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggau .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<<..>>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<...<<<<<<....>>>>>>....<<<......>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<...<<<.....>>>.>.....>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((())))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((.......(((....)))......))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((..(((...((((........)))).....(((....)))...)))..)))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((.......(((.....)))......)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((..........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}... Complex of 70S ribosome with cognate tRNA-Tyr in the P-site; 16S ribosomal RNA 4wzd 2L 78 3.1 RF00005 URS00002D9DE2_562 26037619 0030533 0006412 562 gguggggnucccgagngccaaagggagcagacunuanaucugccgucuucgaaggnucgaauccuucccccaccacca <<<<<<<..<<<..........>>>.<<<<<.......>>>>>.......<<<<<.......>>>>>>>>>>>>.... (((((((...(.....[......)..((((.........)))).......(((((..]....)))))))))))).... Complex of 70S ribosome with cognate tRNA-Tyr in the P-site; tRNA-Tyr 4wzd 3L 85 3.1 RF00005 URS00002D9DE2_562 26037619 0030533 0006412 562 gguggggnucccgagcngccaaagggagcagacunuanaucugccgucaucgacuucgaaggnucgaauccuucccccaccacca <<<<<<<..<<<...........>>>.<<<<<.......>>>>>.<<<...>>>...<<<<<.......>>>>>>>>>>>>.... (((((((..(((...........))).((((.........)))).((.....))...(((((.......)))))))))))).... Complex of 70S ribosome with cognate tRNA-Tyr in the P-site; tRNA-Tyr 4wzd 14 2909 3.1 RF02540,RF02541,RF00002 URS0000868533_300852 26037619 0003735 0005840 300852 ggucaagaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaacggcccgcacgcgggccgaaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggauguuggcuuagaagcagccaucauuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucuugacc .<<..<<<......<<<<<<<<<<<.....[[..[[<<<<<<[[<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<..>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...(((....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>.]]...............<<....>>....]].........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....<<<<..........>>>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<...<....<...........>....>..........<........>....>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..((((...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.........<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<....<<<......<<<<<<<<....>>>>>>>>...>>>..............>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<.(((..>>>>..)))>>>>>>.............>>>>..]]>>>>.......<<<<.<<<<<<<<...<<.......>>...>>>>>>>..>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))))>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>..>>. ..............((((((((((.....(((..((((((((((((......((((((.[[..[[[)))...].((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((..)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...(((((((((..).))))))))....{.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).))))....(((((((((.[.....)))))))))....}.(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....((..............))....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((.(...((..........)..).)..)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(<((((((.....(.....((..((((((((((.....{.(.((....(...(.(.......).)...).......(..............)..)).)...)))))))))).))..........]]].)...>))))))))))...)))))))(((((((.......)))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((..(((((((((.(.........((.(...((.......((..((((....))))...))...)).............).))).)))))))))..)))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....((((((..((..]]]]..)).)))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(...........)....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)........ Complex of 70S ribosome with cognate tRNA-Tyr in the P-site; 23S ribosomal RNA 4wzd 1J 122 3.1 RF00001 URS00005AB4A7_300852 26037619 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga ..<<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> ...((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).)))))))))). Complex of 70S ribosome with cognate tRNA-Tyr in the P-site; 5S ribosomal RNA 4wzo 13 1497 3.3 RF00177,RF01959,RF01960 URS000080E226_300852 26037619 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugg .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<........>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>.....<......>....>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<...<<<.....>>>>......>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.. .....(((...[.[[[...))).((((.(((((..(((((((((....(((.(((..(((..((.(.((..........)).).)))))......(((......((((((((..((...((((((..(((((.....((((......))))......)))))....((((.(((((....))))).))))...((((...))))..))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(.....(((.....)))......)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((.(..((((((((((......((........))........(.(((((((..(...((((..((..((((((......)))))).................))..))))).((.(((...((((((.(....(((((((((....)))...((........))...)))))).....((((.(((((((...(...(((.....))).)....))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..).))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}. Complex of 70S ribosome with tRNA-fMet and mRNA; 16S ribosomal RNA 4wzo 1K 70 3.3 RF00005 URS000057545F_83333 26037619 0030533 0006412 83333 cgcgggguggagcaggagcucgucgggnucauaacccgaaggucgucggnuaaauccggcccccgcaacc .<<<<<<..<<<<....>>>>.<<<<<.......>>>>>......<<<<......>>>>.>>>>>>.... .((((....(((......))).(((((.......))))).....(((.(......).)))..)))).... Complex of 70S ribosome with tRNA-fMet and mRNA; tRNA-fMet 4wzo 2K 77 3.3 RF00005 URS000057545F_83333 26037619 0030533 0006412 83333 cgcggggnggagcagcccgguagcucgucgggnucauaacccgaagnucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Complex of 70S ribosome with tRNA-fMet and mRNA; tRNA-fMet 4wzo 3K 76 3.3 RF00005 URS00005AA258_83333 26037619 0030533 0006412 83333 gcccgganagcucagucgguagagcaggggauugaanauccccgunuccuugguucgauuccgaguccgggcacca <<<<<<<...<<<........>>>..<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... ..(..((...(((........)))..((((.........))))......((((.......)))).))..)...... Complex of 70S ribosome with tRNA-fMet and mRNA; tRNA-Phe 4wzo 4K 13 3.3 26037619 300852 aaaaugaaaaaaa ............. ............. Complex of 70S ribosome with tRNA-fMet and mRNA; mRNA 4wzo 1H 2902 3.3 RF02540,RF02541,RF00002 URS0000868533_300852 26037619 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaacggcccgcacgcgggccgaaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggauguuggcuuagaagcagccaucauuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.....>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....<<<<<<......>>>>>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<.......<<......>>........>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<.....<.........>.....>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<.<<<<<<<<<...........<<.<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>.>>..>>>>>>>>>.>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<..<<<<<<<<..<<.......>>>..>>>>>>>...>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...................<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......(.((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((......(...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)..)))))).)))]....((((.(((..[......))).))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))).).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....(................)....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((.......(........)........))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......(.(.(..((....(.........)....))......(...((......)).).).).)...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(((((((...(((......(((((.(((....))))))))...)))..))))).)).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...((.((........)).))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((....(((((((((((((((.((.....))))))))).....))))))))...)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((.((((((((((((.(.........((..(....(......(.((..((....))..)).)...)..............)..))).)))))))))))).)))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.((.((.........)).))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))..(((.......)).)...(((((((((.......)))))....((((((((..((....(((.(....).)))...))...))))).)))...))))....))) Complex of 70S ribosome with tRNA-fMet and mRNA; 23S ribosomal RNA 4wzo 16 122 3.3 RF00001 URS00005AB4A7_300852 26037619 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga ...<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>. ...((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).)))))))))). Complex of 70S ribosome with tRNA-fMet and mRNA; 5S ribosomal RNA 4wzo 1G 1497 3.3 RF00177,RF01959,RF01960 URS000080E226_300852 26037619 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugg .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<....>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>....<<<<.<<<<<....>>>>>.>>>>...<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<..[.>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>.......]..<<<((.....<<<<...<<<.<<<<<<.<<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>....<<......>>...>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<...<<<.....>>>.>.....>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.. .....(((...[.[[[...))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((..)))))))).)))))......(((......((((((((..((...(((((((.(((((....((((.(....).)))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((.......(((....)))......))))....(((((...(....((((.....)))).....)....)))))......(((((.[[...(((((.....((.]].)).......))))))))))..)))))))))..........(((.[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((.]..)).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((.(((..(...(((..(((..((((((......)))))).................)))..)))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....(((..((((((........(((.....))).......)))))).....(((((....))))).........))).....).).)))...)).)))))....))).)))..[)).)))))))).(...((((.((.....(((..(...(((......)))...)....))).....)).))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}. Complex of 70S ribosome with tRNA-fMet and mRNA; 16S ribosomal RNA 4wzo 2L 77 3.3 RF00005 URS000057545F_83333 26037619 0030533 0006412 83333 cgcggggnggagcagcccgguagcucgucgggnucauaacccgaagnucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Complex of 70S ribosome with tRNA-fMet and mRNA; tRNA-fMet 4wzo 3L 76 3.3 RF00005 URS00005AA258_83333 26037619 0030533 0006412 83333 gcccgganagcucagucgguagagcaggggauugaanauccccgunuccuugguucgauuccgaguccgggcacca ..<<.....<<<<........>>>>.<<<<<<.....>>>>>>.....<<<...........>>>...>>...... ..(..(...((((........)))).((((.........)))).....(.(((.......)).)).)..)...... Complex of 70S ribosome with tRNA-fMet and mRNA; tRNA-Phe 4wzo 14 2877 3.3 RF02540,RF02541,RF00002 URS0000868533_300852 26037619 0003735 0005840 300852 aagaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaacggcccgcacgcgggccgaaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggauguuggcuuagaagcagccugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacgccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggu ..........<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<..>>>>>>.>>....<<<<<.....<......>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>..........<......>.........>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<....<<<<<......>>>>.>....>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<......<.<<<<<......................<<......>>...>>>>>.>..>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<..<<<<<<<...<<.......>>...>>>>>>>...>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<.............>>>>....>>>.>>>>.......>>>>>>>..<<.>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>..... ..........((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((......)))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((((((((..).))))))))....(.(((((((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((.(((((....))))).))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....((..............))....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((.(((((.(...(((((((((...((....(((.(((....((...............))....))).)))...).)...)))))))))..)..))))).).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[.....((((((.....(.....((..((((((((.(.....{...((.......................(........)....)).....).)))))))).))..........]]].)....)))))).)))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.((...{{....))))))(((....(((((((((((((((.((.....))))))))).....))))))))...)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((.((((.(((.(..........((.(..(((.......(..((((....))))...)...)))............).)).).))).)))).)))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.((((...........))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((.))....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))...). Complex of 70S ribosome with tRNA-fMet and mRNA; 23S ribosomal RNA 4wzo 1J 122 3.3 RF00001 URS00005AB4A7_300852 26037619 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga ...<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>. ..((.((((((((....((((((((....((.((((...(.....)...))))...))...)))))).))(((.......((.(((((....))))).)).......))).)))))))).)) Complex of 70S ribosome with tRNA-fMet and mRNA; 5S ribosomal RNA 4x4n D 31 2.953 URS000080E2D0_9606 25640237 9606 ggccgcggcagguucgauccugccgcgaucg <<.<<<<<<<<<......>>>>>>>>>.>>. (..(((((((((......)))))))))..). Crystal structure of the A.fulgidus CCA-adding enzyme in complex with a G70A arginyl-tRNA minihelix; G70A tRNA minihelix 4x4r D 30 3.202 URS000080DD43_9606 25640237 9606 ggccgcggcagguucgauccugccgccacc <<<...<<<<<<......>>>>>>>>>... (((...((((((......)))))))))... Crystal structure of the A.fulgidus CCA-adding enzyme in complex with a G70A arginyl-tRNA minihelix ending in CCACC and AMPcPP; G70A tRNA minihelix ending in CCACC 4x4t B 34 2.5 URS000080E288_9606 25640237 9606 ggccgcggcaggnucgaauccngccgcgancgcc <<<<<<<<<<<<.......>>>>>>>>>...>>> ((((((((((((.......)))))))))...))) Crystal structure of the A.fulgidus CCA-adding enzyme in complex with a G70A arginyl-tRNA minihelix ending in CCACCA; G70A tRNA minihelix ending in CCACCA 4x4t D 30 2.5 URS000080E288_9606 25640237 9606 ggccgcggcaggnucgauccngccgcggcc <<<<<<<<<<<<......>>>>>>>>>>>> ((((((((((((......)))))))))))) Crystal structure of the A.fulgidus CCA-adding enzyme in complex with a G70A arginyl-tRNA minihelix ending in CCACCA; G70A tRNA minihelix ending in CCACCA 4x4u B 31 2.7 URS000080E308_9606 25640237 9606 ggcgcugcgggguucgaguccccgugccacc <<<<...<<<<<.......>>>>>>>>>... (((....(((((.......))))).)))... Crystal structure of the A.fulgidus CCA-adding enzyme in complex with a human MenBeta minihelix ending in CCACC; human MenBeta minihelix 4x62 A 1512 3.4492 RF00177,RF01959,RF01960 URS000080DE21_300852 26751643 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauccuuucu ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<.......>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<<....>>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<...<<<.....>>>>.>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>........... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.....)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((.(((..(((((((....)))))))....(((....)))....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(....(((.....)))..)...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((.((((((...(.((((....(((....))).)))).)..)))))).))))))..))).))))..).))...)..)..(((((((((....)))))))))}.......... Crystal Structure of 30S ribosomal subunit from Thermus thermophilus; 16S rRNA 4x62 b 11 3.4492 URS000080DD95_300852 26751643 300852 gacunuunauc <<.......>> (.........) Crystal Structure of 30S ribosomal subunit from Thermus thermophilus; RNA (5'-D(P*GP*AP*CP*UP*(70U)P*UP*UP*(12A)P*AP*(PSU)P*C)-3') 4x64 A 1512 3.35 RF00177,RF01959,RF01960 URS000080DE21_300852 26751643 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauccuuucu ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<.......>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<<....>>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<...<<<.....>>>.>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>........... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.....)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((.(((..(((((((....)))))))....(((....)))....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(.....((.....))...)...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.......... Crystal Structure of 30S ribosomal subunit from Thermus thermophilus; 16S rRNA 4x64 b 11 3.35 URS000080DD95_300852 26751643 300852 gacunuunauc <<.......>> ........... Crystal Structure of 30S ribosomal subunit from Thermus thermophilus; RNA (5'-D(P*GP*AP*CP*UP*(70U)P*UP*UP*(12A)P*AP*(PSU)P*C)-3') 4x65 A 1512 3.345 RF00177,RF01959,RF01960 URS000080DE21_300852 26751643 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauccuuucu ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<.......>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<.<..<<<<<<<....>>>>>>>...<<<<....>>>>..>.>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<...<<<.....>>>.>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<<..>>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>........... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.....)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((..((..(((((((....)))))))....(((....)))....)).))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(....(((.....)))..)...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((.((((((...(.((((....(((....))).)))).)..)))))).))))))..))).))))..).))...)..)..(((((((((....)))))))))}.......... Crystal Structure of 30S ribosomal subunit from Thermus thermophilus; 16S rRNA 4x65 b 11 3.345 URS000080DD95_300852 26751643 300852 gacunuunauc <<.......>> ........... Crystal Structure of 30S ribosomal subunit from Thermus thermophilus; RNA (5'-D(P*GP*AP*CP*UP*(70U)P*UP*UP*(12A)P*AP*(PSU)P*C)-3') 4x66 A 1512 3.446 RF00177,RF01959,RF01960 URS000080DE21_300852 26751643 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauccuuucu ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<.......>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<<....>>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<...<<<.....>>>.>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>........... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.....)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((..((..(((((((....)))))))....(((....)))....)).))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(....(((.....)))..)...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((.((((((...(.((((....(((....))).)))).)..)))))).))))))..))).))))..).))...)..)..(((((((((....)))))))))}.......... Crystal Structure of 30S ribosomal subunit from Thermus thermophilus; 16S rRNA 4x66 b 11 3.446 URS000080DD95_300852 26751643 300852 gacunuunauc <<.......>> ........... Crystal Structure of 30S ribosomal subunit from Thermus thermophilus; RNA (5'-D(P*GP*AP*CP*UP*(70U)P*UP*UP*(12A)P*AP*(PSU)P*C)-3') 4xej A16S 1504 3.8 RF00177,RF01959,RF01960 URS000080DD36_262724 25652826 0003735 0005840 262724 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgaggaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<<.....>>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<.<<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<<....>>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((((((((.......))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((......(.]]])........))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((.(((((...))))).))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..(((((((.((......((........))..........(((((((..(...((((((((..((((((......))))))...((((....))))..))))))))).(..(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..((...(((.....)))).)...)))))))..(..(((((....))))).....)..)))).....).).)))...)).))).)....)))))))..[))..))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. IRES bound to bacterial Ribosome; 16S ribosomal RNA 4xej A23S 2876 3.8 RF02540,RF02541,RF00002 URS000080DEC7_262724 25652826 0003735 0005840 262724 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgucuaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccagggguuggcuuagaagcagccauccuuuaaagagugcguaauagcuccuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaaaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagcuccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcuggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagacuacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.....>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<..<<..<<<<.......>>>>..>>..........<<......>>...>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>....>>>>>>>>>..>>>....<<<<....>>>>......>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<.<<<<<<<<<<<.<.........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>>.>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<.<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>......>>>..>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<<.....>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([....(((((((.....))))))).....(.(((.(((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))..)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..(((.......))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((.(.((((((......)))).)))..)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{..((((.((..(((.........)))..))......(...((......)).)))))....)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.((...{{....))))))(((...((((((((((((((((.((.....)))))))))....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(.(((((..(((...((...(((((....)))))...))...))))))))...))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((.(.((((..((((((((((...........(((((..(.(......((((((((....))))))))...).)............)))))..)))))))))).))))...(((((....)))))....).))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.((((...........))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....((((((..((..]]]]..)).)))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))...(.........).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) IRES bound to bacterial Ribosome; 23S ribosomal RNA 4xej A5S 119 3.8 RF00001 URS000080DE2B_262724 25652826 0003735 0005840 262724 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<.....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>..>>>>>>>>> ..(((((((((....((((((.(....(((((((.............))))..)))...).)))).))(((.......((.(((((....))))).)).......))).))))))))). IRES bound to bacterial Ribosome; 5S ribosomal RNA 4xej B16S 1504 3.8 RF00177,RF01959,RF01960 URS000080DD36_262724 25652826 0003735 0005840 262724 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgaggaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<...<..<<<.<<<..<<<..<<.<<<<<<<<<<.....>>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>...>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<.<..<<<<<<<.<..<<<......>>>.....>.>>>>>>>...>.......<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<.......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<......>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>....>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..((((((((.....(((.(((..(((..((.(((((((((.......))))))))).)))))......(.(......((((((((...(...(.(((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).))))).)..).))))))))(((.....((..((((((((.......)))))))))).......)))..((((((((....))))...))))).).(((((............))))).((((....))))...)))))).......(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..((((((((....((((((((....((((((....((........)).......))))))....).......((....)).)))))))...)))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((.((...)).)))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((..((((((.((..(((((..((((((.(((......((........))..........(((((((..(...((((((((..(((((((....)))))))...((((....))))..))))))))).(..(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..((...(.(.....).)).)...)))))))..(..(((((....))))).....)..)))).....).).)))...)).))).)....)))))))..[)).).)))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))).))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.. IRES bound to bacterial Ribosome; 16S ribosomal RNA 4xej B23S 2876 3.8 RF02540,RF02541,RF00002 URS000080DEC7_262724 25652826 0003735 0005840 262724 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgucuaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccagggguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaaaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagcuccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcuggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagacuacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....[[..[[<<<<<<[[<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.....>>>>>>.>>....<<<<<.....<......>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...(((....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>.]]...............<<....>>....]].........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<.<.<<<<<<......>>>>.>>>..>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<..<<<<.......>>>>..>>..........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..((((...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.........<<<<.[[<<<<..<<<<..<<<.<<<<<.<<<<<<<<<<<<<<<.<.........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>>.>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>...>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<..((..>>>>..)).>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<.<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>......>>>..>....<<<<<<<....>>>.>>>>........)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))))>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<<.....>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((......(...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)..)))))).)))]....((((.((((.[.....)))).))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...).)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((....((.((((.(.((.(((......)))..)))..)))).))...)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.((..(((.........)))..))......(..............).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.((...{{....))))))(((...((((((((((((((((.((.....)))))))))....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.[..).....)))))((((((((((((.....))))))))))))(...).......(((((((((...((.........))...(((((((.....(((....))).......))))))).]((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((.((((((((((.............(((..(((......((((((((....))))))))...)))............)))....)))))))))).))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((]..[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]]........((.((..((..]]]]..)).)).))......)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....))))))).....(.....).......(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) IRES bound to bacterial Ribosome; 23S ribosomal RNA 4xej B5S 119 3.8 RF00001 URS000080DE2B_262724 25652826 0003735 0005840 262724 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<.....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>..>>>>>>>>> ..(((((((((....((((((((....(((.(((...(.....)...)))...)))...)))))).))(((.......((.(((((....))))).)).......))).))))))))). IRES bound to bacterial Ribosome; 5S ribosomal RNA 4xej AIRE 32 3.8 RF00458 URS00008116AA_64698 25652826 0043022 64698 cgcucaaacauuaagugguguugugccacuuc ..<.<.<<<<<.(((((>>>>>>.>.))))). .[[.....[[[.(((((]]]....]]))))). IRES bound to bacterial Ribosome; IRES RNA 4xej BIRE 32 3.8 RF00458 URS00008116AA_64698 25652826 0043022 64698 cgcucaaacauuaagugguguugugccacuuc ..<...<<<<<.(((((>>>>>..>.))))). .[[.[.[.[[[.(((((]]].]].]]))))). IRES bound to bacterial Ribosome; IRES RNA 4xw0 A 10 1.81 URS00008FED46_9606 26543073 9606 gccunccugc .......... .......... Crystal structure of (GCCU(G-LNA)CCUGC)2 duplex; RNA (5'-R(*GP*CP*CP*UP*(LCG)P*CP*CP*UP*GP*C)-3') 4xw0 B 10 1.81 URS00008FED46_9606 26543073 9606 gccunccugc .......... .......... Crystal structure of (GCCU(G-LNA)CCUGC)2 duplex; RNA (5'-R(*GP*CP*CP*UP*(LCG)P*CP*CP*UP*GP*C)-3') 4y1i A 100 2.85 URS00008116C1_1360 25794619 1360 aaaggggaguagcgucgggaaaccgaaacaaagucgucaauucgugaggaaacucaccggcuuuguugacauacgaaaguauguuuagcaagaccuuucc <<<<<......<<.<<<<....>>>><<<<<<<<<........<<<<<....>>>>>.>>>>>>>>><<<<<<<....>>>>>>>..>>....>>>>>.. (((((......((.((((....))))((((((((((.......(((((....)))))))))))))))(((((((....)))))))..))....))))).. Lactococcus lactis yybP-ykoY Mn riboswitch bound to Mn2+; Lactococcus lactis yybP-ykoY riboswitch 4y1i B 100 2.85 URS00008116C1_1360 25794619 1360 aaaggggaguagcgucgggaaaccgaaacaaagucgucaauucgugaggaaacucaccggcuuuguugacauacgaaaguauguuuagcaagaccuuucc <<<<<......<<.<<<<....>>>><<<<<<<<<........<<<<<....>>>>>.>>>>>>>>><<<<<<<....>>>>>>>..>>....>>>>>.. (((((......((.((((....))))((((((((((.......(((((....)))))))))))))))(((((((....)))))))..))....))))).. Lactococcus lactis yybP-ykoY Mn riboswitch bound to Mn2+; Lactococcus lactis yybP-ykoY riboswitch 4y1j B 100 2.24 URS00008116BC_1360 25794619 1360 aaaggggaguagcgucgggaaaccgaaacaaagucgucuauucgugaggaaacucaccggcuuuguugacauacgaaaguauguuuagcaagaccuuucc <<<<<......<<.<<<<....>>>><<<<<<<<<........<<<<<....>>>>>.>>>>>>>>><<<<<<<....>>>>>>>..>>....>>>>>.. (((((......((.((((....))))((((((((((.......(((((....)))))))))))))))(((((((....)))))))..))....))))).. Lactococcus lactis yybP-ykoY Mn riboswitch A41U binding site mutant in presence of Mn2+; yybP-ykoY riboswitch 4y4o 1A 2872 2.3 RF02540,RF02541,RF00002 URS00001698E8_300852 25775268 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<......>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((..(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...((((((((.(.((((((......)))).)))..))))))))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((...................))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((.((((((.(......[..(((((..(((......((((((.(....).))))))...)))..........].)))))).)))))).)))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..((((.))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the Thermus thermophilus 70S ribosome with rRNA modifications and bound to protein Y (YfiA) at 2.3A resolution; 23S Ribosomal RNA 4y4o 1B 120 2.3 RF00001 URS000080DEE8_300852 25775268 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>. .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the Thermus thermophilus 70S ribosome with rRNA modifications and bound to protein Y (YfiA) at 2.3A resolution; 5S Ribosomal RNA 4y4o 1a 1500 2.3 RF00177,RF01959,RF01960 URS000080DFED_300852 25775268 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<..[.>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>.......]..<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>.....<......>....>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((..)))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((...(((((((....)))))))...((((....))))...)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the Thermus thermophilus 70S ribosome with rRNA modifications and bound to protein Y (YfiA) at 2.3A resolution; 16S Ribosomal RNA 4y4o 2A 2867 2.3 RF02540,RF02541,RF00002 URS00001698E8_300852 25775268 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..<<<.......>>>...>>>......................>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<.<<<<<......>>>>>>....>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((..))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((.(.((((((......)))).)))..)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((.(........((((.((....((.......)).....)).........(........)...))))....).)))))))).))..........]]].)....))))))))))...)))))))(((((((())))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((.(.((((.(......[..(((((..(((.......((((..........))))....)))..........].)))))).)))).).)))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))((((.))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal structure of the Thermus thermophilus 70S ribosome with rRNA modifications and bound to protein Y (YfiA) at 2.3A resolution; 23S Ribosomal RNA 4y4o 2B 120 2.3 RF00001 URS000080DEE8_300852 25775268 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the Thermus thermophilus 70S ribosome with rRNA modifications and bound to protein Y (YfiA) at 2.3A resolution; 5S Ribosomal RNA 4y4o 2a 1504 2.3 RF00177,RF01959,RF01960 URS000080DFED_300852 25775268 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<....<<<......>>>.......>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>.....<......>....>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((...(((((((....))))))).(...((....))...).)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the Thermus thermophilus 70S ribosome with rRNA modifications and bound to protein Y (YfiA) at 2.3A resolution; 16S Ribosomal RNA 4y4p 1A 2871 2.5 RF02540,RF02541,RF00002 URS00001698E8_300852 25775268 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<....<<<<........>>>..>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..<<......(..>>...>>>.........<<......>>.).>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<.<<....>>.>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...((((((((.....))))))))....{.(((((((((...((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).))))....(((((((((.[.....)))))))))....}.(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((....(((.(......).)..))...)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((..((.........))...))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((..((((((((.(......[..(((((..(((.......(((((((....)))))))....)))..........].)))))).))))))))..))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((...)))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal structure of the Thermus thermophilus 70S ribosome with rRNA modifications and bound to mRNA and A-, P- and E-site tRNAs at 2.5A resolution; 23S Ribosomal RNA 4y4p 1B 120 2.5 RF00001 URS000080DEE8_300852 25775268 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the Thermus thermophilus 70S ribosome with rRNA modifications and bound to mRNA and A-, P- and E-site tRNAs at 2.5A resolution; 5S Ribosomal RNA 4y4p 1a 1500 2.5 RF00177,RF01959,RF01960 URS000080DFED_300852 25775268 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>.<..<<......>>.>..>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((((((....))))))).)))))......(((......((((((((..((...(((((((.(((((.....(((((....)))).).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((.(((....))).)))....(((....)))....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the Thermus thermophilus 70S ribosome with rRNA modifications and bound to mRNA and A-, P- and E-site tRNAs at 2.5A resolution; 16S Ribosomal RNA 4y4p 1v 13 2.5 25775268 10665 aaaaauguucuaa ............. ............. Crystal structure of the Thermus thermophilus 70S ribosome with rRNA modifications and bound to mRNA and A-, P- and E-site tRNAs at 2.5A resolution; mRNA 4y4p 1w 74 2.5 RF00005 URS00005AA258_562 25775268 0030533 0006412 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[..)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of the Thermus thermophilus 70S ribosome with rRNA modifications and bound to mRNA and A-, P- and E-site tRNAs at 2.5A resolution; A-site and E-site tRNAs 4y4p 1x 76 2.5 RF00005 URS000041AF00_562 25775268 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the Thermus thermophilus 70S ribosome with rRNA modifications and bound to mRNA and A-, P- and E-site tRNAs at 2.5A resolution; P-site tRNA 4y4p 1y 74 2.5 RF00005 URS00005AA258_562 25775268 0030533 0006412 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((......)))).((((.........)))).....(((((.......)))))))))))).... Crystal structure of the Thermus thermophilus 70S ribosome with rRNA modifications and bound to mRNA and A-, P- and E-site tRNAs at 2.5A resolution; A-site and E-site tRNAs 4y4p 2A 2800 2.5 RF02540,RF02541,RF00002 URS00001698E8_300852 25775268 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu 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(((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....(())....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...((((..(((...(((...(((.(((......((..........)).......))).)))..)).)...)))..))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((.().)))))))).))..........]]].)....))))))))))...)))))))(((((((..)))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(......[..(((((...((.......((((.((....)).))))....))...........].)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(((...)).....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))...)))) Crystal structure of the Thermus thermophilus 70S ribosome with rRNA modifications and bound to mRNA and A-, P- and E-site tRNAs at 2.5A resolution; 23S Ribosomal RNA 4y4p 2B 120 2.5 RF00001 URS000080DEE8_300852 25775268 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>. ..((((((.((....((((((.(....(((((((...(.....)...))))..)))...).)))).))(((.......((((((((....)))))))).......))).)).)))))).. Crystal structure of the Thermus thermophilus 70S ribosome with rRNA modifications and bound to mRNA and A-, P- and E-site tRNAs at 2.5A resolution; 5S Ribosomal RNA 4y4p 2a 1503 2.5 RF00177,RF01959,RF01960 URS000080DFED_300852 25775268 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggau .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<......>>....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((.(....).)))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((((((....)))))))..................)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.(.((....)).)).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}... Crystal structure of the Thermus thermophilus 70S ribosome with rRNA modifications and bound to mRNA and A-, P- and E-site tRNAs at 2.5A resolution; 16S Ribosomal RNA 4y4p 2v 13 2.5 25775268 10665 aaaaauguucuaa ............. ............. Crystal structure of the Thermus thermophilus 70S ribosome with rRNA modifications and bound to mRNA and A-, P- and E-site tRNAs at 2.5A resolution; mRNA 4y4p 2w 72 2.5 RF00005 URS00005AA258_562 25775268 0030533 0006412 562 cccgganagcucagggagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<..<<<<.....>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((...[.)))).((((.........))))......((((..]....)))).))))))..... Crystal structure of the Thermus thermophilus 70S ribosome with rRNA modifications and bound to mRNA and A-, P- and E-site tRNAs at 2.5A resolution; A-site and E-site tRNAs 4y4p 2x 76 2.5 RF00005 URS000041AF00_562 25775268 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the Thermus thermophilus 70S ribosome with rRNA modifications and bound to mRNA and A-, P- and E-site tRNAs at 2.5A resolution; P-site tRNA 4y4p 2y 73 2.5 RF00005 URS00005AA258_562 25775268 0030533 0006412 562 gcccgganagcucagggagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<.....>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[.)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of the Thermus thermophilus 70S ribosome with rRNA modifications and bound to mRNA and A-, P- and E-site tRNAs at 2.5A resolution; A-site and E-site tRNAs 4ybb AA 1534 2.1 RF00177,RF01959,RF01960 URS000081169C_83333 25775265 0003735 0005840 83333 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<.<<........>>.>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>.............>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((.(...((....))...)..)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..(......))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(..(.((((((((.......)))))))).)...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((.....(..........).......(....)...))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..((.......))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...((((((......(((..((...(((....)))...))....)))......))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... High-resolution structure of the Escherichia coli ribosome; 16S rRNA 4ybb BA 1533 2.1 RF00177,RF01959,RF01960 URS000081169C_83333 25775265 0003735 0005840 83333 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<......>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<.<......<<........>>..........<<<<<<<.......<<<<<<..<<<<..........>>>>...<......>..>>>>>.>..<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<...<<<.....>>>.>.....>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>..>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((.((.(........).))..)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..........)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(..(.((((((((.......)))))))).)...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((((.......)))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((...(((((((((......((........))..........(((.(((..(...(((..((..((((..........)))).............))..).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....))).)))...)).)))))))..(...(((((((.....(((..((...(........)...))....))).....)))))))......(....(((.(((........))).)))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... High-resolution structure of the Escherichia coli ribosome; 16S rRNA 4ybb CA 2898 2.1 RF02540,RF02541 URS00004B0F34_83333 25775265 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccuu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<.<....<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>..>>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<...>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<.<<....>>.>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<..<<....>>...>>>>>.>.....>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>.............>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>.. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))((((..(....)..)))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((.......).))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(...((......)).).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((..........))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((...(((...(((....)))...)))...)))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((.(......).(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.(..(.(..........(.....(((......((((((((....))))))))...)))...............).).)..).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).).....((.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..))....(.(((((....))).)).)....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))).. High-resolution structure of the Escherichia coli ribosome; 23S rRNA 4ybb CB 118 2.1 RF00001 URS0000049E57_83333 25775265 0003735 0005840 83333 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))). High-resolution structure of the Escherichia coli ribosome; 5S rRNA 4ybb DA 2897 2.1 RF02540,RF02541 URS000080E25C_83333 25775265 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<...>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<......>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>.>......>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<..<<<............<<<<<...<<<<....<<<<<<<<....>>>>>>>>.>>>>.............>>>.>>..>>>..>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((........))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((.(((.(((...(((((......)))))[[(...).(((.....]])))...)))...))).)))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((.((...))..))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((((......))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((((((((...((..(............((...((......(.((((((....)))))).)...)).............))...)..))...))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).).....((.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..))....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). High-resolution structure of the Escherichia coli ribosome; 23S rRNA 4ybb DB 120 2.1 RF00001 URS0000049E57_83333 25775265 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). High-resolution structure of the Escherichia coli ribosome; 5S rRNA 4yhw C 17 3.25 URS0000868549_4932 26161500 4932 auccuuaugcacgggaa ................. ................. Yeast Prp3 (296-469) in complex with fragment of U4/U6 di-snRNA; U4 snRNA fragment 4yhw D 17 3.25 URS0000868549_4932 26161500 4932 auccuuaugcacgggaa ................. ................. Yeast Prp3 (296-469) in complex with fragment of U4/U6 di-snRNA; U4 snRNA fragment 4yhw E 27 3.25 URS0000868515_4932 26161500 4932 uuccccugcauaaggaugaaccguuuu ........................... ........................... Yeast Prp3 (296-469) in complex with fragment of U4/U6 di-snRNA; U6 snRNA fragment 4yhw F 27 3.25 URS0000868515_4932 26161500 4932 uuccccugcauaaggaugaaccguuuu ........................... ........................... Yeast Prp3 (296-469) in complex with fragment of U4/U6 di-snRNA; U6 snRNA fragment 4yn6 A 19 2.301 URS000080E08C_32630 26148061 32630 uugggccagcagcaggucc ................... ................... Structural Insight reveals dynamics in repeating r(CAG) transcript found in Huntington's disease (HD) and Spinocerebellar ataxias (SCAs); RNA (5'-R(P*UP*UP*GP*GP*GP*CP*CP*AP*GP*CP*AP*GP*CP*AP*GP*GP*UP*CP*C)-3') 4yn6 B 19 2.301 URS000080E08C_32630 26148061 32630 uugggccagcagcaggucc ................... ................... Structural Insight reveals dynamics in repeating r(CAG) transcript found in Huntington's disease (HD) and Spinocerebellar ataxias (SCAs); RNA (5'-R(P*UP*UP*GP*GP*GP*CP*CP*AP*GP*CP*AP*GP*CP*AP*GP*GP*UP*CP*C)-3') 4ypb QA 1511 3.4 RF00177,RF01959,RF01960 URS000080E226_300852 26508639 0003735 0005840 300852 guuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggcuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucaccuccuuu ......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<.>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<.<<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<......>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<...<<...<<<.....>>>.>>....>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.............. ......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((.((((.)))).)))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((((..(((((((....)))))))...((.(.....)))..))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}............. Precleavage 70S structure of the P. vulgaris HigB DeltaH92 toxin bound to the AAA codon; 16S rRNA 4ypb QV 77 3.4 RF00005 URS000041AF00_562 26508639 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Precleavage 70S structure of the P. vulgaris HigB DeltaH92 toxin bound to the AAA codon; tRNA fMet 4ypb QW 77 3.4 RF00005 URS000041AF00_562 26508639 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(.(((.......))).)))))))..... Precleavage 70S structure of the P. vulgaris HigB DeltaH92 toxin bound to the AAA codon; tRNA fMet 4ypb QX 20 3.4 26508639 562 caaggagguaaaaaugnnnu .................... .................... Precleavage 70S structure of the P. vulgaris HigB DeltaH92 toxin bound to the AAA codon; messenger RNA 4ypb RA 2891 3.4 RF02540,RF02541,RF00002 URS000080DFFB_300852 26508639 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgggccggcccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<<<<<..>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<.<.<<<<<<......>>>>.>>>..>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..<<<<.......>>>>..>>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<...<<......<<<<<<<<....>>>>>>>>...>>.............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<<..<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>>......>>>>>>>..<<<<.....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((.(.[[..[[.).).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((((((((..).))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((((((()))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((...((((((......)))).))...)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......(((((.(((..(((.........)))..))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((.((((((((((((...........(((((..(((......((((((((....))))))))...)))............)))))..)))))))))))).)))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))...(((.....))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Precleavage 70S structure of the P. vulgaris HigB DeltaH92 toxin bound to the AAA codon; 23S rRNA 4ypb RB 122 3.4 RF00001 URS000080E212_300852 26508639 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga ..<<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> ..(((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).))))))))))) Precleavage 70S structure of the P. vulgaris HigB DeltaH92 toxin bound to the AAA codon; 5S rRNA 4ypb XA 1508 3.4 RF00177,RF01959,RF01960 URS000080E226_300852 26508639 0003735 0005840 300852 guuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucaccuccuuu ......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<..>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<........>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<...<<...<<<.....>>>.>>....>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.............. ......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((.(.))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((...(((((((....)))))))...((.(.....)))...)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}............. Precleavage 70S structure of the P. vulgaris HigB DeltaH92 toxin bound to the AAA codon; 16S rRNA 4ypb XV 77 3.4 RF00005 URS000041AF00_562 26508639 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Precleavage 70S structure of the P. vulgaris HigB DeltaH92 toxin bound to the AAA codon; tRNA fMet 4ypb XW 77 3.4 RF00005 URS000041AF00_562 26508639 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(((((.......)))))))))))..... Precleavage 70S structure of the P. vulgaris HigB DeltaH92 toxin bound to the AAA codon; tRNA fMet 4ypb XX 20 3.4 26508639 562 caaggagguaaaaaugnnnu .................... .................... Precleavage 70S structure of the P. vulgaris HigB DeltaH92 toxin bound to the AAA codon; messenger RNA 4ypb YA 2875 3.4 RF02540,RF02541,RF00002 URS000080DFFB_300852 26508639 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>....<<<<<.....<......>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<.<.<<<<<<......>>>>.>>>..>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<<........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>.>>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<...<<......<<<<<<<<....>>>>>>>>...>>.............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[[)))...].((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((((((((..).))))))))....(.(((((((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((...((((((......)))).))...))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......(((((.(((..(((.........)))..))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((((..))))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((.(((((.((((...........(((((..(((......((((((((....))))))))...)))............)))))..)))).))))).)))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.((((.....))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Precleavage 70S structure of the P. vulgaris HigB DeltaH92 toxin bound to the AAA codon; 23S rRNA 4ypb YB 122 3.4 RF00001 URS000080E212_300852 26508639 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga ..<<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> ..(((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).))))))))))) Precleavage 70S structure of the P. vulgaris HigB DeltaH92 toxin bound to the AAA codon; 5S rRNA 4yzv QA 1511 3.1 RF00177,RF01959,RF01960 URS000080E226_300852 26508639 0003735 0005840 300852 guuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggcuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucaccuccuuu ......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<.>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<......>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<...<<...<<<.....>>>.>>....>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.............. ......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((.((((.)))).)))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((((..(((((((....)))))))...((.(.....)))..))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}............. Precleavage 70S structure of the P. vulgaris HigB deltaH92 toxin bound to the ACA codon; 16S rRNA 4yzv QV 77 3.1 RF00005 URS000041AF00_562 26508639 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Precleavage 70S structure of the P. vulgaris HigB deltaH92 toxin bound to the ACA codon; P-site tRNA-fMet 4yzv QX 20 3.1 26508639 562 caaggagguaaaaaugnnnu .................... .................... Precleavage 70S structure of the P. vulgaris HigB deltaH92 toxin bound to the ACA codon; messenger RNA 4yzv RA 2891 3.1 RF02540,RF02541,RF00002 URS000080DFFB_300852 26508639 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgggccggcccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>....<<<<<.....<......>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<<<<<..>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<.<.<<<<<<......>>>>.>>>..>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..<<<<.......>>>>..>>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<...<<......<<<<<<<<....>>>>>>>>...>>.............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> .((......((((((((((.....(((..((((((((((((......((((.(.[[..[[.).).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((((((((..).))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((((((()))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((...((((((......)))).))...)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......(((((.(((..(((.........)))..))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((.((((((((((((...........(((((..(((......((((((((....))))))))...)))............)))))..)))))))))))).)))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))..((((.....))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....)). Precleavage 70S structure of the P. vulgaris HigB deltaH92 toxin bound to the ACA codon; 23S rRNA 4yzv RB 122 3.1 RF00001 URS000080E212_300852 26508639 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga ..<<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> ..(((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).))))))))))) Precleavage 70S structure of the P. vulgaris HigB deltaH92 toxin bound to the ACA codon; 5S rRNA 4yzv XA 1508 3.1 RF00177,RF01959,RF01960 URS000080E226_300852 26508639 0003735 0005840 300852 guuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucaccuccuuu ......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<..>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<........>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<...<<...<<<.....>>>.>>....>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.............. ......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((.(.))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((((..(((((((....)))))))...((.(.....)))..))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}............. Precleavage 70S structure of the P. vulgaris HigB deltaH92 toxin bound to the ACA codon; 16S rRNA 4yzv XV 77 3.1 RF00005 URS000041AF00_562 26508639 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Precleavage 70S structure of the P. vulgaris HigB deltaH92 toxin bound to the ACA codon; P-site tRNA-fMet 4yzv XX 20 3.1 26508639 562 caaggagguaaaaaugnnnu .................... .................... Precleavage 70S structure of the P. vulgaris HigB deltaH92 toxin bound to the ACA codon; messenger RNA 4yzv YA 2875 3.1 RF02540,RF02541,RF00002 URS000080DFFB_300852 26508639 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>....<<<<<.....<......>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<<........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>.>>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<...<<......<<<<<<<<....>>>>>>>>...>>.............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((((((((..).))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((.(.((((((......)))).)))..))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......(((((.(((..(((.........)))..))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((((..))))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((.((((((((((...........(((((..(((......((((((((....))))))))...)))............)))))..)))))))))).)))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.((((.....))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Precleavage 70S structure of the P. vulgaris HigB deltaH92 toxin bound to the ACA codon; 23S rRNA 4yzv YB 122 3.1 RF00001 URS000080E212_300852 26508639 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga ..<<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> ..(((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).))))))))))) Precleavage 70S structure of the P. vulgaris HigB deltaH92 toxin bound to the ACA codon; 5S rRNA 4z31 C 14 2.5 URS0000868522_9606 26489670 9606 uguucugugaacac .............. .............. Crystal structure of the RC3H2 ROQ domain in complex with stem-loop and double-stranded forms of RNA; RNA (5'-R(*A)-D(P*UP*GP*UP*UP*CP*UP*GP*UP*GP*AP*AP*CP*AP*C)-3') 4z31 D 14 2.5 URS0000868522_9606 26489670 9606 auguucugugaaca .............. .............. Crystal structure of the RC3H2 ROQ domain in complex with stem-loop and double-stranded forms of RNA; RNA (5'-R(*A)-D(P*UP*GP*UP*UP*CP*UP*GP*UP*GP*AP*AP*CP*AP*C)-3') 4z3s 1A 2871 2.65 RF02540,RF02541,RF00002 URS00001698E8_300852 26028538 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<.....<<<........>>>......>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<.<<<.........>>>..>>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<.<..>.>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((...((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((.....((..........))......)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((..((.........))...))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((.(((((((((.(......[..(((((..(((......((((((((....))))))))...)))..........].)))))).))))))))).))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((...)))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with antibiotic A201A, mRNA and three tRNAs in the A, P and E sites at 2.65A resolution; 23S Ribosomal RNA 4z3s 1B 120 2.65 RF00001 URS000080DEE8_300852 26028538 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the Thermus thermophilus 70S ribosome in complex with antibiotic A201A, mRNA and three tRNAs in the A, P and E sites at 2.65A resolution; 5S Ribosomal RNA 4z3s 1a 1500 2.65 RF00177,RF01959,RF01960 URS000080DFED_300852 26028538 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<..[.>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>.......]..<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>....<<......>>...>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((..)))))))).)))))......(((......((((((((..((...(((((((.(((((....(((((......))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((((((....))))))).(..(((....))).)..)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the Thermus thermophilus 70S ribosome in complex with antibiotic A201A, mRNA and three tRNAs in the A, P and E sites at 2.65A resolution; 16S Ribosomal RNA 4z3s 1v 14 2.65 26028538 10665 aaaaauguucuaau .............. .............. Crystal structure of the Thermus thermophilus 70S ribosome in complex with antibiotic A201A, mRNA and three tRNAs in the A, P and E sites at 2.65A resolution; mRNA 4z3s 1w 74 2.65 RF00005 URS00005AA258_562 26028538 0030533 0006412 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[..)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with antibiotic A201A, mRNA and three tRNAs in the A, P and E sites at 2.65A resolution; A/E-site tRNAs 4z3s 1x 76 2.65 RF00005 URS000041AF00_562 26028538 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with antibiotic A201A, mRNA and three tRNAs in the A, P and E sites at 2.65A resolution; P-site tRNA 4z3s 1y 74 2.65 RF00005 URS00005AA258_562 26028538 0030533 0006412 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((......)))).((((.........)))).....((.((.......)).))))))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with antibiotic A201A, mRNA and three tRNAs in the A, P and E sites at 2.65A resolution; A/E-site tRNAs 4z3s 2A 2800 2.65 RF02540,RF02541,RF00002 URS00001698E8_300852 26028538 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>....<<<<<.....<......>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<....<<<<........>>>.>....>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<..>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<<.....<<<<<<<<<..>>>>>>>>>..>>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((()))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((.........................)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((....)))))))).))..........]]].)....))))))))))...)))))))(((((.(()).)))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(......[..(((((..(((......(((((.((....)).)))))...)))..........].)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....))))))).((...)).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with antibiotic A201A, mRNA and three tRNAs in the A, P and E sites at 2.65A resolution; 23S Ribosomal RNA 4z3s 2B 120 2.65 RF00001 URS000080DEE8_300852 26028538 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>>> .((((((..((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).))..)))))). Crystal structure of the Thermus thermophilus 70S ribosome in complex with antibiotic A201A, mRNA and three tRNAs in the A, P and E sites at 2.65A resolution; 5S Ribosomal RNA 4z3s 2a 1503 2.65 RF00177,RF01959,RF01960 URS000080DFED_300852 26028538 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggau .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>.....<......>....>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((.(....).)))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((((..(((((((....))))))).(....(....)....)))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}... Crystal structure of the Thermus thermophilus 70S ribosome in complex with antibiotic A201A, mRNA and three tRNAs in the A, P and E sites at 2.65A resolution; 16S Ribosomal RNA 4z3s 2v 13 2.65 26028538 10665 aaaaauguucuaa ............. ............. Crystal structure of the Thermus thermophilus 70S ribosome in complex with antibiotic A201A, mRNA and three tRNAs in the A, P and E sites at 2.65A resolution; mRNA 4z3s 2w 73 2.65 RF00005 URS00005AA258_562 26028538 0030533 0006412 562 gcccgganagcucagggagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<.....>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... .((((((..((((...[.)))).((((.........)))).....(((((..]....)))))))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with antibiotic A201A, mRNA and three tRNAs in the A, P and E sites at 2.65A resolution; A/E-site tRNAs 4z3s 2x 76 2.65 RF00005 URS000041AF00_562 26028538 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with antibiotic A201A, mRNA and three tRNAs in the A, P and E sites at 2.65A resolution; P-site tRNA 4z3s 2y 73 2.65 RF00005 URS00005AA258_562 26028538 0030533 0006412 562 gcccgganagcucagggagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<.....>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[.)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with antibiotic A201A, mRNA and three tRNAs in the A, P and E sites at 2.65A resolution; A/E-site tRNAs 4z4c B 19 2.303 URS000080E33F_32630 26359634 32630 uucacauugcccaagucuu ................... ................... Human Argonaute2 Bound to t1-C Target RNA; RNA (5'-R(P*UP*UP*CP*AP*CP*AP*UP*UP*GP*CP*CP*CP*AP*AP*GP*UP*CP*UP*U)-3') 4z4d B 20 1.6 URS000080E33F_32630 26359634 32630 uucacauugcccaagucuuu .................... .................... Human Argonaute2 Bound to t1-G Target RNA; RNA (5'-R(P*UP*UP*CP*AP*CP*AP*UP*UP*GP*CP*CP*CP*AP*AP*GP*UP*CP*UP*UP*U)-3') 4z4e B 19 1.8 URS000080E33F_32630 26359634 32630 uucacauugcccaagucuu ................... ................... Human Argonaute2 Bound to t1-U Target RNA; RNA (5'-R(P*UP*UP*CP*AP*CP*AP*UP*UP*GP*CP*CP*CP*AP*AP*GP*UP*CP*UP*U)-3') 4z4f B 18 2.8 URS000080E33F_32630 26359634 32630 uucacauugcccaaguuu .................. .................. Human Argonaute2 Bound to t1-DAP Target RNA; RNA (5'-R(P*UP*UP*CP*AP*CP*AP*UP*UP*GP*CP*CP*CP*AP*AP*GP*UP*UP*U)-3') 4z4f D 10 2.8 URS0000868548_32630 26359634 32630 caaugugana .......... .......... Human Argonaute2 Bound to t1-DAP Target RNA; RNA (5'-R(*CP*AP*AP*UP*GP*UP*GP*AP*(N6G)P*A)-3') 4z4g B 20 2.7 URS000080E33F_32630 26359634 32630 uucacauugcccaagucuuu .................... .................... Human Argonaute2 Bound to t1-Inosine Target RNA; RNA (5'-R(P*UP*UP*CP*AP*CP*AP*UP*UP*GP*CP*CP*CP*AP*AP*GP*UP*CP*UP*UP*U)-3') 4z4h B 20 2.504 URS000080E33F_32630 26359634 32630 uucacauugcccaagucuuu .................... .................... Human Argonaute2 A481T Mutant Bound to t1-A Target RNA; RNA (5'-R(P*UP*UP*CP*AP*CP*AP*UP*UP*GP*CP*CP*CP*AP*AP*GP*UP*CP*UP*UP*U)-3') 4z4i B 20 2.801 URS000080E33F_32630 26359634 32630 uucacauugcccaagucuuu .................... .................... Human Argonaute2 A481T Mutant Bound to t1-G Target RNA; RNA (5'-R(P*UP*UP*CP*AP*CP*AP*UP*UP*GP*CP*CP*CP*AP*AP*GP*UP*CP*UP*UP*U)-3') 4z8c 1A 2746 2.9 RF02540,RF02541,RF00002 URS00001698E8_300852 25984972 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccagcuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<..>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>>....<<<..>>>......>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<......>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((..(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((.(.((((((......)))).)))..))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{..((.().))....)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((((....)))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..((((.))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the Thermus thermophilus 70S ribosome bound to translation inhibitor oncocin; 23S ribosomal RNA 4z8c 1B 120 2.9 RF00001 URS000080DEE8_300852 25984972 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the Thermus thermophilus 70S ribosome bound to translation inhibitor oncocin; 5S ribosomal RNA 4z8c 1a 1477 2.9 RF00177,RF01959,RF01960 URS000080DFED_300852 25984972 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccucgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccugggccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcggucguaacaagguagcuguaccggaaggugcggcugga .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<....>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<...>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>>.>>...>.....<<<<<<<<<....>>>>>>>>>... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((.(((()))).)))).)))))......(((......((((((((..((...(((((((.(((((....(((((......))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((...))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((.(.....).)).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((...(((((((....))))))))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))).))...)..)..(((((((((....)))))))))}.. Crystal structure of the Thermus thermophilus 70S ribosome bound to translation inhibitor oncocin; 16S ribosomal RNA 4z8c 1x 76 2.9 RF00005 URS000041AF00_562 25984972 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the Thermus thermophilus 70S ribosome bound to translation inhibitor oncocin; Initiator Methionine tRNA 4z8c 2A 2790 2.9 RF02540,RF02541,RF00002 URS00001698E8_300852 25984972 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<.<.<<<<<<......>>>>.>>>..>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<....<<.......>>....>>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<....>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...((((((((.....))))))))....{.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).))))....(((((((((.[.....)))))))))....}.(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((..))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((.(....(((......)))....)..)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{..((((.(((...(............)..))).........((......))...))))....)))))))))).))..........]]].)....))))))))))...)))))))(((((((())))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((..))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(..((((.........))))....).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))((((.))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal structure of the Thermus thermophilus 70S ribosome bound to translation inhibitor oncocin; 23S ribosomal RNA 4z8c 2B 120 2.9 RF00001 URS000080DEE8_300852 25984972 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>. ..(((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).))))))))).. Crystal structure of the Thermus thermophilus 70S ribosome bound to translation inhibitor oncocin; 5S ribosomal RNA 4z8c 2a 1483 2.9 RF00177,RF01959,RF01960 URS000080DFED_300852 25984972 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccugggccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcggucguaacaagguagcuguaccggaaggugcggcuggau .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>>.>>...>.....<<<<<<<<<....>>>>>>>>>.... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((((((....))))))))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))).))...)..)..(((((((((....)))))))))}... Crystal structure of the Thermus thermophilus 70S ribosome bound to translation inhibitor oncocin; 16S ribosomal RNA 4z8c 2x 76 2.9 RF00005 URS000041AF00_562 25984972 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the Thermus thermophilus 70S ribosome bound to translation inhibitor oncocin; Initiator Methionine tRNA 4zc7 A 21 3.041 URS0000868553_32630 26264664 32630 gcgucguuccggaaaagucgc ..................... ..................... Paromomycin bound to a leishmanial ribosomal A-site; RNA duplex 4zc7 B 20 3.041 URS0000868553_32630 26264664 32630 gcgucguuccggaaagucgc .................... .................... Paromomycin bound to a leishmanial ribosomal A-site; RNA duplex 4zc7 C 21 3.041 URS0000868553_32630 26264664 32630 gcgucguuccggaaaagucgc ..................... ..................... Paromomycin bound to a leishmanial ribosomal A-site; RNA duplex 4zc7 D 20 3.041 URS0000868553_32630 26264664 32630 gcgucguuccggaaagucgc .................... .................... Paromomycin bound to a leishmanial ribosomal A-site; RNA duplex 4zer 1A 2824 3.1 RF02540,RF02541,RF00002 URS00001698E8_300852 25984971 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccagcuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<..>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<......>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((..(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...((((((((.(.((((((......)))).)))..))))))))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.((((..))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(......[..(((((..(((......((((((........))))))...)))..........].)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((.))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal structure of the Onc112 antimicrobial peptide bound to the Thermus thermophilus 70S ribosome; 23s ribosomal RNA 4zer 1B 120 3.1 RF00001 URS000080DFF2_300852 25984971 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the Onc112 antimicrobial peptide bound to the Thermus thermophilus 70S ribosome; 5s ribosomal RNA 4zer 1a 1500 3.1 RF00177,RF01959,RF01960 URS000080DFED_300852 25984971 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<..))).>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<......>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((..)))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((...(((((((....)))))))....(((....)))....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the Onc112 antimicrobial peptide bound to the Thermus thermophilus 70S ribosome; 16s ribosomal RNA 4zer 1x 76 3.1 RF00005 URS00002905B5_83333 25984971 0030533 0006412 83333 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the Onc112 antimicrobial peptide bound to the Thermus thermophilus 70S ribosome; tRNA met 4zer 2A 2869 3.1 RF02540,RF02541,RF00002 URS00001698E8_300852 25984971 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<.....<.......>......>>......................>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<.<<<<<...........<<<<<..<<<......<<.<<<<......>>>>>>....>>>............>>>>>..>>>>>.>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...((((((((.....))))))))....{.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).))))....(((((((((.[.....)))))))))....}.(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((.().))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...((((((((.(.((((((......)))).)))..))))))))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......(((((.((....((.......)).....)).....(...(........).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))(((((((())))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((..((((.(......[..(((((..(((.......(.((((......))))).....)))..........].)))))).)))).).)))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(((...)).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal structure of the Onc112 antimicrobial peptide bound to the Thermus thermophilus 70S ribosome; 23s ribosomal RNA 4zer 2B 120 3.1 RF00001 URS000080DFF2_300852 25984971 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>>. .((((((.(((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).))).)))))). Crystal structure of the Onc112 antimicrobial peptide bound to the Thermus thermophilus 70S ribosome; 5s ribosomal RNA 4zer 2a 1504 3.1 RF00177,RF01959,RF01960 URS000080DFED_300852 25984971 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>.................>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((.(..).)))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((((((....))))))).(...(......)...).)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the Onc112 antimicrobial peptide bound to the Thermus thermophilus 70S ribosome; 16s ribosomal RNA 4zer 2x 76 3.1 RF00005 URS00002905B5_83333 25984971 0030533 0006412 83333 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the Onc112 antimicrobial peptide bound to the Thermus thermophilus 70S ribosome; tRNA met 4zsn QA 1511 3.6 RF00177,RF01959,RF01960 URS000080E226_300852 27378776 0003735 0005840 300852 guuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggcuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucaccuccuuu ......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<...>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<.<<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<......>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<...<<...<<<.....>>>.>>....>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.............. ......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((.((((.)))).)))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((((..(((((((....)))))))...((.(.....)))..))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}............. 70S-wild-type HigB toxin complex bound to a AAA lysine codon; 16S rRNA 4zsn QV 77 3.6 RF00005 URS000041AF00_562 27378776 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... 70S-wild-type HigB toxin complex bound to a AAA lysine codon; P-site tRNA-fMet 4zsn QX 20 3.6 27378776 32630 caaggagguaaaaaugnnnu .................... .................... 70S-wild-type HigB toxin complex bound to a AAA lysine codon; messenger RNA 4zsn RA 2891 3.6 RF02540,RF02541,RF00002 URS000080DFFB_300852 27378776 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgggccggcccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>....<<<<<.....<......>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<<<<<..>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<.<.<<<<<<......>>>>.>>>..>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..<<<.........>>>..>>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<...<<......<<<<<<<<....>>>>>>>>...>>.............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((((((((..).))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((((((..))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((...((((((......)))).))...)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......(((((.(((..(((.........)))..))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((.((((((((((((...........(((((..(((......((((((((....))))))))...)))............)))))..)))))))))))).)))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....((((((..((..]]]]..)).)))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))..((((.....))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) 70S-wild-type HigB toxin complex bound to a AAA lysine codon; 23S rRNA 4zsn RB 122 3.6 RF00001 URS000080E212_300852 27378776 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga ..<<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> ..(((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).))))))))))) 70S-wild-type HigB toxin complex bound to a AAA lysine codon; 5S rRNA 4zsn XA 1508 3.6 RF00177,RF01959,RF01960 URS000080E226_300852 27378776 0003735 0005840 300852 guuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucaccuccuuu ......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<..>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<......>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<...<<...<<<.....>>>.>>....>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.............. ......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((.(.))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((((((....)))))))...((((....))))...)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}............. 70S-wild-type HigB toxin complex bound to a AAA lysine codon; 16S rRNA 4zsn XV 77 3.6 RF00005 URS000041AF00_562 27378776 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... 70S-wild-type HigB toxin complex bound to a AAA lysine codon; P-site tRNA-fMet 4zsn XX 20 3.6 27378776 32630 caaggagguaaaaaugnnnu .................... .................... 70S-wild-type HigB toxin complex bound to a AAA lysine codon; messenger RNA 4zsn YA 2875 3.6 RF02540,RF02541,RF00002 URS000080DFFB_300852 27378776 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>....<<<<<.....<......>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<.<.<<<<<<......>>>>.>>>..>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<...<<......<<<<<<<<....>>>>>>>>...>>.............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((((((((..).))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((.(.((((((......)))).)))..))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((.(.......(((((.(((..(((.........)))..))).....(...((......)).).)))))...).)))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((((..))))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((.((((((((((...........(((((..(((......((((((((....))))))))...)))............)))))..)))))))))).)))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.((((.....))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) 70S-wild-type HigB toxin complex bound to a AAA lysine codon; 23S rRNA 4zsn YB 122 3.6 RF00001 URS000080E212_300852 27378776 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga ..<<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> ..(((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).))))))))))) 70S-wild-type HigB toxin complex bound to a AAA lysine codon; 5S rRNA 5a2q 2 1665 3.9 RF01960,RF01959,RF00177 URS0000868562_9606 26155016 0003735 0005840 9606 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucguacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgccggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucucucucggccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgaccggucggcguaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcguguccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggugcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<....<<....<<<<<.........<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<<<....>>>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<..>>>>>>>.>>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....<<<<<<<<<.<<<....>>>..>>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<...<<.<<<..>>>>>...<<<<<<.<.......<<...<.......>.<<<<.>>>>...>>......>.>>>..>>>........<.<<.<<<<<<<...............>>>>>>>.>>.>....>>....<<<<<<..<...<<<<..<<<.<<<<<<<<...<<<......>>>......>>>>>>>>.>>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<......>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<<<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<..>>>.>>>>>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>...>.>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<.<<<........<.<<<.<<<<....>>>>.>>>....>.........>>>.>>............<<<<<..........>>>>>...........>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<.<<<<<<<<<..>>>>>>>>>...>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..((....((((.....([...((.....((.(((.....))).))......))......)..((((...((((((....))))))...))))((..(((((...(......)..)))))......)).(]((((.(((())))))))).).)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).).....(((((((((.(((....)))..)))))).)))....(.((..(...........)..))......)..((((([[....(.((((.....((..]])).......))))))))))..)))))).)))..[......(.([[...(.(.((...(((......((.(((())))))...((((((.(.......((..((.......)).(((.)))....))......).)))..)))........(.((.(((((((...............))))))).)).).........(((.(((..(...((((..(((.((((((((...((........))......)))))))).))).......((....))...))))..)..)))..))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.((((......)))))))))).)..)))...((..]]))...))...].))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....((((((....(..((.(((........))).))....)))))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((...(...((((..((.((((((((()))).))))).))..))))..).....(((((.....)))))........)))....))).))).....).))))).....).)))))...)).)))).))).(...((.(((........(.(((.((((....)))).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..((((.((...(((((((((((((((()))))))))).).)))))...)).))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}........ Structure of the HCV IRES bound to the human ribosome; 18S RRNA 5a2q 3 257 3.9 RF00061 URS000086855D_11103 26155016 0043022 11103 cuccccugugaggaacuacugucuucacgcagaaagcgucuagccauggcguuaguaugagugucgugcagccuccaggacccccccucccgggagagccauaguggucugcggaaccggugaguacaccggaauugcgagauuugggcgugcccccgcaagacugcuagccgaguaguguugggucgcgaaaggccuugugguacugccugauagggugcuugcgagugccccgggaggucucguagaccaccaug ....<<<<.<<<<.....<<<<<..<<<.<<....<<<<<.......>>>>>.....>>.>>>..>.>>>>>>>>>>>>......<<<<<<<<<<<.<<<<<<<<<<<<<<<<<..<<<<<<....>>>>>><<<<....>>>>.<<<<..>>>>>>>>.>>>>>>>>><<<.....<<........>>....>>>....>>>>.>><<<<....>>>><<..(((((.>>>>>>>>>>>.)))))........... ....((((.((((.....(((((..(((.(.....(((((.......)))))......).)))..).))))))))))))......(((((((((((.((((((((((.((((((..((((((....))))))((((.().)))).((((..)))))))).)).))))))(((.....((........))....)))(..)))))[))((((..].))))((..[[[[[.))))))))))).]]]]]........... Structure of the HCV IRES bound to the human ribosome; HCV IRES 5a8l A 253 3.8 RF02543,RF02540 URS00008FED4F_9606 26384426 0003735 0005840 9606 ugacgugcaaaucaaucgaaccaucgcaggaagguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugcgcaauuaguaacuaugacuugccucguccgcauaaaccaagaagacccucuggggcggaccacagggauaacuggcuuguggccaagcguucauagcgacuuuuugauccuucgaugucggcuuguucagaacgugacuggguuuagaacagguuaguuuuaacgagagg .<<........>>............<<<<<..<....<<.........>>....>..........<<......>>...>>>>>......<<<.......>>>...................<<......<<<<<.....>>.....>>>.......<<.<.<.<.....<<.......>>...>...>>.>.>.......<.<<................>>..>....<.......>....>>......... .((.......[))............(((((.......((.........))................(......)....)))))......((.........))...................((......((((.......).....))).......((.(.(.(.....((.......))...)...)).).)........(((.(.....)........)).).....((.....))..].))..(....). Human eRF1 and the hCMV nascent peptide in the translation termination complex; 28S RIBOSOMAL RNA 5a8l B 67 3.8 RF01960,RF01959,RF00177 URS00005A14E2_9606 26384426 0003735 0005840 9606 ugccagcgcgguaacggcuuaauuugacucaacggugcauaugccaccgcgucgcuacguaaaaguc .....<..>.........................<<..<..>>>......<.<..<<..>>...>.> .....(())........................(((...().))).....(.(..((()))...).) Human eRF1 and the hCMV nascent peptide in the translation termination complex; HUMAN 18S RIBOSOMAL RNA 5a8l P 18 3.8 URS00008FED3B_9606 26384426 9606 gggauuaggaauccccca .<<<<.....>>>>.... (((((.....)))))... Human eRF1 and the hCMV nascent peptide in the translation termination complex; P-SITE TRNA 5a9z AA 2889 4.7 RF02540,RF02541,RF00002 URS0000868519_300852 26283392 0003735 0005840 300852 ggucaagaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaugcggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgaggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucuugacc ....<.........<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<.<....>.>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<.......<....<<<<<..<<..<<<...<<<<........>>>>(.......<<.......).>>...>>>....>>...>>>>>...>...>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<...<.....<......>.....>.....<<....>>...<<......>>.......>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<<...<<<<<<......>>>>>>....>>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<.....<...<<<<<<<......<<.........>>........>>>>>>>..>......>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<((......<<<<<<<..........<<..<<<<<.<<.........<<<<<.<<.....................>>.........<........>...>>>>>.....>>.>>>>>.>>...........))......>>>>>>>.>>>...>>>>>>><<.<<<<.......>>>>.>>....>>>>>><<<<<<<...<<<......<<<<<.<......>.>>>>>...>>>..>>>>>.>>.....>>>>>>.......<......<<<<<<.......>>>>>><<<<....<<<<..<<..<<<<<<<...<<.....>>.>>>>>>>...((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<.....<.<.....<<<<..<<<..<<<<<.<<<<.<<...[[[...>>>>>><.....<<<..<...<<<<<<..<.......>.>>>>>>.......>.>>>.....><.....<<<....>>>......>>>>>>...>>>...>>>>..........>.>........>>>>>>>>>>>>>>>..>>.....<<......>>.>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.<<<........>>>..>>>>>>............<<<<<<<<<..<<<<.......>>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>>.<<.<<.......>>.>>.....................<<<<<<.....>>>>>>..........>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>.>...........<<<<<........>>>>>..<<<<<<<<.<<<.<<......<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<......>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<..<<<<<<<...<<.......>>...>>>>>>>...>>>.>.......<.<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>......>>>..>....<<<<<<<....>>>.>>>>....>>..>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]].>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...................<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>......>..... ..............(((((((((((....(((..((((((((((.(......(((((((....[[)))).....((((((...(((]].....)))......))))))...)))....(((....)))((((((((....)))))))).((............)).)....((((((.....(......)......)))))..)........((....))...(((((.....((.....))....)))))..((((....((((((((.....))))))))......((((((((.....((...((((((.(((..(((...(((((......)))))[[(...).(((.....]])))...)))....)))..))))))..)).))))).))).....(((((((((.......)))))))))......((((((.[[.))))))..)))).....)).)))))).))...............((....))....)).........((((....)))).............)....))))))))))).......(((((((((((....)))))))))))...(............).((((((....(((((((((((((..((....(.(.....).)....))...((....))...(((.....)))......)))))))))))))..((.(...((((((...((((((((((((.((((...((((((......))))))....))))...(((..((((........)))).)))..).))))))))))).(((.....)))......))))))......).))..((((((....(((((....))))).((((((((.(.(.(((((((((.(.(((...(((((.((.........................)).)))))..)).).).))))))))).).).))))))).)...(((((((.((......)).))))))).....(((......)))...((((.(((...(((.[....(.(((((((..........((..(((((...............((...............................(...((......)).).))...........))))).))...........].......)))))))))))...)))))))((((((((.....))))))))....))))))..(((((...(((......(((((.(......).)))))...)))..)))))........)))))).......((.....((((((.......))))))((((....((((..(...(((((((...((.....)).)))))))...[[(((..((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((.....((((....((((..(((..(((((.((((.((.........))))))(((...((...(((((((((((.((.....)))))))))).....))).))....))).(..((((....))))..)...)))))...)))...)))).........))))........))))))))))).)))...).....((......)).)))).((((......))))..))))..((((....((((((((.(((...............((((....(....).....)))).((((((.(.(.........).).))))))(...).......(((((((((..(((((.....)))))..(((((((.....(((....))).......)))))))..((((.((...(((((((..(((...((...(((((....)))))...))...))))))))..)).)).......................................((((((.....))))))..........))))...)).)))))))....))).)))))))).))))))........[..(((((......].)))))..((((((((.(((.((......((((.((((((..(((((.(((.((((..((((((((((((((((.(......[..(((((..((((.....((((((((....))))))))..))))..........].)))))).))))))))))))))))...(((((....))))).....)))).)))..)))))..((((.....))))((((((...........))))))([((...(((((((.(.((((((.......))))))...).((][.[..))....)))))))...((((..(((......)))..)))).(((....))).))..].].....(((((((.((....]]..))))))))).....).......))))..))))))........(((.((((((((...((.......))...))))))))..)))..........((((.((((((..(((((((((......)))))))..)).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....))..)))))))))))....((((((((..((((..(((.(....................)))).(((((...(((....(((((((((((....))))))...)))))....))).)))))...(((....(((((...........)))))....))).))))......)))))))).....(.....).......(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))............ Complex of Thermous thermophilus ribosome bound to BipA-GDPCP; 23S ribosomal RNA 5a9z AB 123 4.7 RF00001 URS00001170B4_300852 26283392 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcgggggau ..<<<<<<<<<<<....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>..>....>>>.>>>>>>>>>>>. ..(((((((((((....((((((((.....((((((.............))))..))....)))))).)).((.......((((((((....)))))))).......))..))))))))))). Complex of Thermous thermophilus ribosome bound to BipA-GDPCP; 5S ribosomal RNA 5a9z BA 1515 4.7 RF00177,RF01959,RF01960 URS000080DFBF_300852 26283392 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucaccuccuuu ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<...<..<<<.<<<..<<<..<<.<<<<<<<<<.......>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<............>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>...>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<(......<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<....<<<......>>>.......>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<...)>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<.......<<<<<<<..<<<<<<<....>>>>>>>.<.<<<<....>>>>.>>>>>>>>..<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<..<<<<<<....<...<<<.....>>>.>.....>>>>>>.....<<<<<....>>>>>.........>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<.<<.<<........>>>>..>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>.......<<....<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>.....>>.........<<<<<<<<<....>>>>>>>>>.............. ....(((((.[.[[[.))))).((((.((((([.((((((.((....(((.(((..(((..((.(((((((((((...))))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).).]))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........(((.......((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((...(((((((....(((......))).......)))))))...).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))..........((((((..((((((((((...))))))))))...((....)).....)))))).))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((......((((((((..(((((((....))))))).(.((((....)))).)))))))))..((.(((...((((((.((...(((((((((....)))..((((......))))..))))))......(((.(((((((..(.(..(((.....)))).)...))))))).....((((......))))........))).....)).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(.....(........).....)....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))....(..((....(((.(.(..(((((((((((((...(.((.(......(....)...).)).)..)))))))))))))..).).))).....))...).....(((((((((....))))))))).............. Complex of Thermous thermophilus ribosome bound to BipA-GDPCP; 16S ribosomal RNA 5aa0 AA 2889 5.0 RF02540,RF02541,RF00002 URS0000868519_300852 26283392 0003735 0005840 300852 ggucaagaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaugcggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgaggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucuugacc ....<.........<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<.<....>.>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<.......<....<<<<<..<<..<<<...<<<<........>>>>(.......<<.......).>>...>>>....>>...>>>>>...>...>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<...<.....<......>.....>.....<<....>>...<<......>>.......>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<<...<<<<<<......>>>>>>....>>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<.....<...<<<<<<<...........................>>>>>>>..>......>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<((......<<<<<<<..........<<..<<<<<.<<.........<<<<<.<<.....................>>.........<........>...>>>>>.....>>.>>>>>.>>...........))......>>>>>>>.>>>...>>>>>>><<.<<<<.......>>>>.>>....>>>>>><<<<<<<...<<<......<<<<<.<......>.>>>>>...>>>..>>>>>.>>.....>>>>>>.......<......<<<<<<.......>>>>>><<<<....<<<<..<<..<<<<<<<...<<.....>>.>>>>>>>...((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<.....<.<.....<<<<..<<<..<<<<<.<<<<.<<...[[[...>>>>>><.....<<<..<...<<<<<<..<.......>.>>>>>>.......>.>>>.....><.....<<<....>>>......>>>>>>...>>>...>>>>..........>.>........>>>>>>>>>>>>>>>..>>.....<<......>>.>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.<<<........>>>..>>>>>>............<<<<<<<<<..<<<<.......>>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>>.<<.<<.......>>.>>.....................<<<<<<.....>>>>>>..........>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>.>...........<<<<<........>>>>>..<<<<<<<<.<<<.<<......<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<......>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<..<<<<<<<...<<.......>>...>>>>>>>...>>>.>.......<.<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>......>>>..>....<<<<<<<....>>>.>>>>....>>..>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]].>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...................<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>......>..... ..............(((((((((((....(((..((((((((((.(......(((((((....[[)))).....((((((...(((]].....)))......))))))...)))....(((....)))((((((((....)))))))).((............)).)....((((((.....(......)......)))))..)........((....))...(((((.....((.....))....)))))..((((....((((((((.....))))))))......((((((((.....((...((((((.(((..(((...(((((......)))))[[(...).(((.....]])))...)))....)))..))))))..)).))))).))).....(((((((((.......)))))))))......((((((.[[.))))))..)))).....)).)))))).))...............((....))....)).........((((....)))).............)....))))))))))).......(((((((((((....)))))))))))...(............).((((((....(((((((((((((..((....(.(.....).)....))...((....))...(((.....)))......)))))))))))))..((.(...((((((...((((((((((((.((((...((((((......))))))....))))...(((..((((........)))).)))..).))))))))))).(((.....)))......))))))......).))..((((((....(((((....))))).((((((((.(.(.(((((((((.(.(((...(((((.((.........................)).)))))..)).).).))))))))).).).))))))).)...(((((((.((......)).))))))).....(((......)))...((((.(((...(((.[....(.(((((((..........((..(((((...............((...............................(...((......)).).))...........))))).))...........].......)))))))))))...)))))))((((((((.....))))))))....))))))..(((((...(((......(((((.(......).)))))...)))..)))))........)))))).......((.....((((((.......))))))((((....((((..(...(((((((...((.....)).)))))))...[[(((..((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((.....((((....((((..(((..(((((.((((.((.........))))))(((...((...(((((((((((.((.....)))))))))).....))).))....))).(..((((....))))..)...)))))...)))...)))).........))))........))))))))))).)))...).....((......)).)))).((((......))))..))))..((((....((((((((.(((...............((((....(....).....)))).((((((.(.(.........).).))))))(...).......(((((((((..(((((.....)))))..(((((((.....(((....))).......)))))))..((((.((...(((((((..(((...((...(((((....)))))...))...))))))))..)).)).......................................((((((.....))))))..........))))...)).)))))))....))).)))))))).))))))........[..(((((......].)))))..((((((((.(((.((......((((.((((((..(((((.(((.((((..((((((((((((((((.(......[..(((((..((((.....((((((((....))))))))..))))..........].)))))).))))))))))))))))...(((((....))))).....)))).)))..)))))..((((.....))))((((((...........))))))([((...(((((((.(.((((((.......))))))...).((][.[..))....)))))))...((((..(((......)))..)))).(((....))).))..].].....(((((((.((....]]..))))))))).....).......))))..))))))........(((.((((((((...((.......))...))))))))..)))..........((((.((((((..(((((((((......)))))))..)).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....))..)))))))))))....((((((((..((((..(((.(....................)))).(((((...(((....(((((((((((....))))))...)))))....))).)))))...(((....(((((...........)))))....))).))))......)))))))).....(.....).......(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))............ Complex of Thermous thermophilus ribosome (A-and P-site tRNA) bound to BipA-GDPCP; 23S ribosomal RNA 5aa0 AB 123 5.0 RF00001 URS00001170B4_300852 26283392 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcgggggau ..<<<<<<<<<<<....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>..>....>>>.>>>>>>>>>>>. ..(((((((((((....((((((((.....((((((.............))))..))....)))))).)).((.......((((((((....)))))))).......))..))))))))))). Complex of Thermous thermophilus ribosome (A-and P-site tRNA) bound to BipA-GDPCP; 5S ribosomal RNA 5aa0 BA 1515 5.0 RF00177,RF01959,RF01960 URS000080DFBF_300852 26283392 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucaccuccuuu ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<...<..<<<.<<<..<<<..<<.<<<<<<<<<.......>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<............>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>...>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<(......<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<....<<<......>>>.......>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<...)>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<.......<<<<<<<..<<<<<<<....>>>>>>>.<.<<<<....>>>>.>>>>>>>>..<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<..<<<<<<....<...<<<.....>>>.>.....>>>>>>.....<<<<<....>>>>>.........>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<.<<.<<........>>>>..>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>.......<<....<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>.....>>.........<<<<<<<<<....>>>>>>>>>.............. ....(((((.[.[[[.))))).((((.((((([.((((((.((....(((.(((..(((..((.(((((((((((...))))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).).]))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........(((.......((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((...(((((((....(((......))).......)))))))...).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))..........((((((..((((((((((...))))))))))...((....)).....)))))).))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((......((((((((..(((((((....))))))).(.((((....)))).)))))))))..((.(((...((((((.((...(((((((((....)))..((((......))))..))))))......(((.(((((((..(.(..(((.....)))).)...))))))).....((((......))))........))).....)).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(.....(........).....)....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))....(..((....(((.(.(..(((((((((((((...(.((.(......(....)...).)).)..)))))))))))))..).).))).....))...).....(((((((((....))))))))).............. Complex of Thermous thermophilus ribosome (A-and P-site tRNA) bound to BipA-GDPCP; 16S ribosomal RNA 5aa0 BC 76 5.0 RF00005 URS00005AA258_300852 26283392 0030533 0006412 300852 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((........)))).((((.........)))).....((.((.......)).))))))))).... Complex of Thermous thermophilus ribosome (A-and P-site tRNA) bound to BipA-GDPCP; tRNA chain 1 5aa0 BD 75 5.0 RF00005 URS000031D44F_300852 26283392 0030533 0006412 300852 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacc .....<...<<<<........>>>>.<<<<<<.....>>>>>>........<<.......>>...>......... .........((............))..((((.......))))......(..((.......))..).......... Complex of Thermous thermophilus ribosome (A-and P-site tRNA) bound to BipA-GDPCP; tRNA chain 2 5aa0 BE 75 5.0 RF00005 URS000031D44F_300852 26283392 0030533 0006412 300852 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacc .........<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>.......... .........((((........)))).(((((.......))))).....(((((.......))))).......... Complex of Thermous thermophilus ribosome (A-and P-site tRNA) bound to BipA-GDPCP; tRNA chain 2 5ady A 117 4.5 RF00001 URS0000049E57_83333 26458047 0003735 0005840 83333 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggc ..<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.....<..<<<<<<<...>>>>>>>....>...>>...>>>>>>>.. .((((((((.....((((((((....(((((((.............))))..)))...)))))).)).((.......((.(((((...))))).)).......))...)))))))). Cryo-EM structures of the 50S ribosome subunit bound with HflX; 5S RRNA 5ady B 2903 4.5 RF02540,RF02541 URS000080E25C_83333 26458047 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu 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((((((((......((((((((((......(...(((((((((((........((((((.[..[[[.)))....(((((((...(((]]]..].))).......)))))).).)))....(((....)))(((((((....))))))).(((((((((.........))))))))).......(((((.........[.........)))))...........((....))...(((((.....((.]...))....)))))...(((..((((......(((((((((((((.(((.....(((......)))..[[(...).(((.....]])))...)))...)))))))))))))...))))........(((((((...........))))))).......((((..[[[[))))...)))......)).))))))).))...............((....)).....)......(..((((.....))))............)......)))))))))).......(.((...((((......))))...)).)...(.(........).).(((.((....(((((.(((((((..((.....(.....).....))...((....))..((((.....)))).....))))))).)))))..((.....((((((.....(((((((((..((((...((((..........))))...).)))...(((...(((........)))..)))....))))))))).(.(((.....)))...)..))))))........))..((((((....((.((....)).))..((.((((...(((((((((.....(((...(((.((((......((.........)).......)))).)))..)).).....)))))).)))...)))).)).....((((((((((......))))))))))....(((......)))...(((..(((...((([[[...(.((((((.....(.....((..((.((..(((.....{..((((.(((..(((.........)))..))).....(..(((......)))).))))....)))..)).)).))...........]]].)...))))))))))...))).)))((((((((......))))))))....))))))(.(((((...(((......((.(((((....))))).))...)))..)))))..).....)).)))(......((.....((((((.......))))))((((.....(((..((....(((((...((.....)).))))).....[[(((....((.(.....((......)).....)..)).....((((........)))).]](((((((((((((...((((....((((..(((..(((((((((((....{{{...)))))).(..((((...((((((((((((.((.....))))))))))..))))...))))...).(..(.(((....))).)...))))))...)))...))))(..).....))))...))....))))))))))).)))..)).....((......)).)))..((((.....))))..))))..((((....((((((((.....[....(.......(((((......[........)))))((((((.....(((...((((.....))))...)))...))))))(...).......(((((((((...(...........)...(((((((.....(((....))).......))))))).]((((.(((..(((((((..(((........(((((..(......)...)))))........))))))))..)))))(((((.........)))))........(...........(((.(.......).))).....)....))))...)).))))))).).(]..))))))))).)))))).....)..[..((.((......].)).))..(((.(((..(((.((......((((.((((((..((.((.(.(.(((((.((((((((.(..(.((........[....((.................(((....))).....................]..))....)))...).))))))))...(((.(((.((.....)).))))))....))))).).)..)).))..(.(......[).)(((((.(.........]))))).)[((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))....((...(((...{..)))...))..(((....))).))]]].].....((.(((...(..]]]]..)..))).))......}......))))..))))))......(.(((.(.((((((...((.......))...))))))...))))...)......((((..(((((..(((((((((......))))))..))).((((.......)))).....)))))......))).)......((((((....))).))).....))..))).))).)))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...((.((((((..}}}...))))..)).))...)))).)))))...(((....(.((.....}.......)).)....))).))))..]....)))))))(.((((((...))))))(....((..(((((.......)))))....(((.((((..((....(((((....)))))...))...))))..))).....))..).))))))))). Cryo-EM structures of the 50S ribosome subunit bound with HflX; 23S RRNA 5afi a 1539 2.9 RF00177,RF01959,RF01960 URS000080DDC0_562 25707802 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<..<<<<<<<.<<....>>.>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<......>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..((((((((.....(((.(((..(((..((.((..((((((...(....)...))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....(((((......)))))......)).).....(((....)))....((((((..(......))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).......(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((((.......)))))))).....)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((..(((((((....))))))).............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((.....((..(((.....)))))......)))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....))))))))..)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... 2.9A Structure of E. coli ribosome-EF-TU complex by cs-corrected cryo-EM; 16S ribosomal RNA 5afi v 77 2.9 RF00005 URS00001BBAFC_562 25707802 0030533 0006412 562 cgcggggnggagcagccuggnagcucgucgggcucauaacccgaagaucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... 2.9A Structure of E. coli ribosome-EF-TU complex by cs-corrected cryo-EM; P-site fMet-tRNAfMet 5afi w 77 2.9 RF00005 URS00001BBAFC_562 25707802 0030533 0006412 562 cgcggggnggagcagccuggnagcucgucgggcucauaacccgaagaucgucggnucaaauccggcccccgcaacca .<<<<<...<<<<.........>>>>..<<<<.......>>>>......<<<<<.......>>>>>.>>>>>..... ...(((([.((.(.]....[..).))..((((.......))))......(.(((..]....))).)))))....... 2.9A Structure of E. coli ribosome-EF-TU complex by cs-corrected cryo-EM; P-site fMet-tRNAfMet 5afi x 11 2.9 25707802 562 aauaauguucg ........... ........... 2.9A Structure of E. coli ribosome-EF-TU complex by cs-corrected cryo-EM; mRNA 5afi y 77 2.9 RF00005 URS000080E05A_562 25707802 0030533 562 gcccgganagcucagncggnagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcaccaF <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>..... (((((((..((((.....[..))))(((((.........)))).)...(((((..]....)))))))))))).... 2.9A Structure of E. coli ribosome-EF-TU complex by cs-corrected cryo-EM; A/T-site Phe-tRNAPhe 5afi A 2900 2.9 RF02540,RF02541 URS0000A76322_562 25707802 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccgggagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<....<.<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>..>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<<..>>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<..<<<<..>>>>...>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<.....<<.........>>.....>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<............>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<......>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<<.<<....>>..>>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>.............>>>>...>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...(((..((((......((((((((((.((.(((...(((((......)))))[[......(((.....]])))...)))...)).))))))))))...))))........((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((((..)))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(..(..(..)..)...)...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[.....((((((.....(.....((..(((((..(((.....{.(((((.(.......................).....(..(((......)))).)))))...)))..))))).))...........]]].)...)))))).)))...)))))))(((((............)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..(((((((((((....{{{...))))))((..((((....((((.((((((.((.....)))))))).)..)))...[))))...))(..(((........)))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((.(......).(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((((((((..(....(.........((.((............((((.(......).))))...................)).)))....)..))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))(.((...(((((((...(((((.........))))).....((.[.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). 2.9A Structure of E. coli ribosome-EF-TU complex by cs-corrected cryo-EM; 23S ribosomal RNA 5afi B 120 2.9 RF00001 URS00008116C5_562 25707802 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). 2.9A Structure of E. coli ribosome-EF-TU complex by cs-corrected cryo-EM; 5S ribosomal RNA 5aj0 A3 157 3.5 RF00002 URS000080DE76_9606 25957688 0003735 0005840 9606 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>.............>>>..)...>>>....<<....>><<<<<<<<.......>>>>>>>>..................... .........................................((((((.[[....[)))...].(.(((......]].............)))..)...)))....((....))(((((((.........)))))))..................... Cryo electron microscopy of actively translating human polysomes (POST state).; 5.8S ribosomal RNA 5aj0 A4 119 3.5 RF00001 URS00000F9D45_9606 25957688 0003735 0005840 9606 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcu .<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>.. .(((((.((....((((((((.....((..((...(....)...))....))....)))))).))((((((......((.((..((....)).)).)).....)))))))).))))).. Cryo electron microscopy of actively translating human polysomes (POST state).; 5S ribosomal RNA 5aj0 A2 3612 3.5 RF02543,RF02540 URS0000868511_9606 25957688 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgcgcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcggcccggcggaucuuucccgcccccggggucggcgggggaccgucccccggaccggcgaccggccgccgccgggcgcauuuccaggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucggggcccccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcgcucuccccccugggggggccgggccaccccucccacggcgcgaccgcucucccagggggcggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccggggggccacgcgcgcgucccgggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgaggggcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcccacgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggccuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcuggcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacaugagagguguagaauaagugggaggcccgggccgccggugaaauaccacuacucugaucguuuuuucacugacccggugaggcgggggggcgagcccgaggggcucucgcuucuggcgccaagcgcccgcccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucgccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccgguccgggguccggugcggagugcccuucguccugggaaacggggcgcggccggaaaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuuguc .........................<<<<<<<....<......>.....>>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..[[[......<.....<<<<<.<......>.>>>>>.......>......<.<<..<<.....<.<......<<...<<<<..........<........>....................................>>>>.>>....>>....>>..>>.>.......<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<.......<..<<.<.<<<<....<<.<<.<..<.........<<.<<<<.<.....<<<<.<<<..<<<<<<<<...>>..>>>>>>>>>>>>>.>>>.>>>>..........>..>>.>.>>....>>>>.>.>>..>..<<<<<<<<.<<<<<<<<<<.<<<........<<.<<<.<<.<....<.<<<<<<<<.>>>>>>>>>.......>>>.>>>>>...........>>>...>>>>>>>>>>....................<<<<...<<<<<<..>>>>>>..<.<<<..<<..<<...<....<.<<<<<...<<...>>.<<<<<<<.<<<<....>>>>.>>>>>>>>>>>>.>....>....>>.....>>.>>>..>.....<<<<<..>>>>>.........>>>>......>>>.>>>>>....>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<......>>>>>>>..<<<<<..<<<......................>>>...>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<........<<<.<<<<<<<<<...<<<....<<<..<.<<<<.<...<<.........>>..>>>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.........>>>>>>>>.>..>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<.......>.>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<<<<<...>>>>>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<...<<<<<<<....>>>>>>>...<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..{{{..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<...............>>>>><<.<<<<<<<<<<<.>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>>..<<<.........>>>..........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<<.<<<<<<<<<<<<.<<<...........<<<<<..<<<<..>>>>............>>>>>..>>>.>>.>>>>>>>>>>...<<<<<.....<<<<........<<<...>>>...................<<<<<<<......>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>>.<<<....>>>.>>)))]......((((((..(((..>>>>>>.)))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]].....<<<<<<.<..<<<....<<<<<.................>>>>>..<<<<....<<<<...<<<.<<<<<<<}}}.>>>>>..>>.>>>..>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.....<<<<<<<.<<..<<<...................<.<<..>>.>..................<<<..<<<<.....<.<.<<<<<<<......>>>>>>>.>>....>>>>..>>>..............>>>...>>>>>>>>><<<<<.<.............>.....<.<<<<<<<.<<.....<<<<....<<<<<......>>>>>...>>>>....>>....>>>>.>>>.>...>>>>>... 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Cryo electron microscopy of actively translating human polysomes (POST state).; 28S ribosomal RNA 5aj0 B1 1708 3.5 RF01960,RF01959,RF00177 URS00005A14E2_9606 25957688 0003735 0005840 9606 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucagaucaaaaccaacccgggcuuuggugacucuagauaaccucgggccgaucgcacgccccccguggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcggccccuugccucucgcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgacccccgagcgguaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccguggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<...[[[[>>>>>[[[.((((((.....{{.........[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[......{{....[[[[[....<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<<<....>>>>>>...>>>>[[..(((((.....<<<<<<<<.<<.>>....<......>..)))))......]]...<<<<..<<<......>>>.>>>>.]].]]]...}}....]]].<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<<...>>>>..>>>......}}.......<<<<<<<<<.<<<....>>>..>>>>>.>>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..)))))).]]]............{{.......{{...[[[.......<<<.....>>>....<.<..<....>>.>....<<<<<.<.......<<...<.......>.<<<<.......>>>>...>>......>.>>>..>>...........[...((((((......>>>>>>>>.))))))...]............<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<........>>>>>>>>>.>..>>>...<<..}}>>...>>.....>>>.....<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<........<<........>>..........<<<<<......<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<..<<..<......>..>>>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.......>>>>>......>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<.<<<<<..>>>>>...>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((...(....((....((..........))...)){)........((.......(((.(.(..((....(((......((.....((..((.....))..))......))..........(((...(.((((....)))).)...))).....(((((......[[[[[[[[((.))....(......)..))))).........(.(.((.((((......)))))).))...)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))..((.(((..........))).)).(.((....)).)...)))))).).......(((...(.((.}...))..))))..)...)).).....(.(((((((.(((....)))..))))).)).)......((.................)).........((((([.....(.((((.....((...])).......))))))))))..)))))).))).........(.({{...(.(.((...(((..(.....((.....))....((.(..((..))).))...(((((.(.......((..((.......)).(((.......)))....))......).)))..))............(...((.((.....]]]]]]]]..)).))....)......)....(((.(((..(...((((..((..((((((((...((........))......))))))))..)).......((....))...))))..)..)))..))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..(.((((((.(((........))))))))).)..)))...((..}}))...)).....))))).).(((......((((....))))....)))...]]].](.(((.(((((((..((..(((((..(((.((((((......((........))........(.(((((.(....(((((........((.(((........))).))......)))))...((.(((...(.((((((.(..(((.(((((....)))..(.((......)))...)).)))....(((...(.(.((((...(((...(..(......)..).)))...))))).).....(((((.....)))))........))).)..))).))).....).))))).....).))))))..)).)))).))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....((((((((.......))))))))......))...))))))))))..)..(.(..((.(..((((.((..(.((((((((.(((..((((.((...(((((.(((((..)))))...)))))...)).))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>........ Cryo electron microscopy of actively translating human polysomes (POST state).; 18S ribosomal RNA 5aj0 Bv 76 3.5 RF00005 URS00005AA258_633 25957688 0030533 0006412 633 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((........)))).(((((.......))))).....((.((.......)).))))))))).... Cryo electron microscopy of actively translating human polysomes (POST state).; tRNA 5aj0 Bw 76 3.5 RF00005 URS00005AA258_633 25957688 0030533 0006412 633 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((........)))).(((((.......))))).....((.((.......)).))))))))).... Cryo electron microscopy of actively translating human polysomes (POST state).; tRNA 5aj0 Bx 28 3.5 25957688 9606 uuuuuuuuuuuuuuuuuuuuuuuuuuuu ............................ ............................ Cryo electron microscopy of actively translating human polysomes (POST state).; mRNA 5aj3 A 960 3.6 RF00177,RF01959 URS00000CFF65_9823 25837512 0003735 0005840 9823 acagguuugguccuggccuuucuauuaauucuuaauaaaauuacacaugcaaguauccgcgccccggugagaaugcccuccagaucuuaaagaucaaaaggagcagguaucaagcacaccuauaacgguagcucauaacgccuugcucaaccacacccccacgggaaacagcagugauaaaaauuaagccaugaacgaaaguuugacuaaguuauauuaauuagaguugguaaaucucgugccagccaccgcggucauacgauuaacccaaauuaauagauccacggcguaaagaguguuuaagaaaaaaaaucacaauagaguuaaauuauaacuaagcuguaaaaagcccuaguuaaaauaaaauaacccacgaaagugacucuaauaauccugacacacgauagcuaggacccaaacugggauuagauaccccacuaugccuagcccuaaacccaaauaguuacauaacaaaacuauucgccagaguacuacucgcaacugccuaaaacucaaaggacuuggcggugcuucacauccaccuagaggagccuguucuauaaucgauaaaccccgauagaccuuaccaacccuugccaauucagccuauauaccgccaucuucagcaaacccuaaaaaggaacaauaguaagcacaaucauagcacauaaaaacguuaggucaagguguagcuuauggguuggaaagaaaugggcuacauuuucuacauaagaauauccaccacacgaaaguuuuuaugaaacuaaaaaccaaaggaggauuuagcaguaaaucaagaauagagugcuugauugaauaaggccaugaagcacgcacacaccgcccgucacccuccucaagcauguaguaauaaaaauaaccuauauucaauuacacaaccaugcaagaagagacaagucguaacaagguaagcauacuggaaagugugcuuggauuacc ..((((..<<<<<<.)))).<<<<<<<<<..<<<<<<<<..<.<<<.<<<..<<....>>......<<......<<<<<...<<<<<...>>>>>...>>>.>>.<<<....<<...<<<......>>>..>>......>>>..<.....>.>>.<<<....>>>.....>>>>>>>.........<<....<<<<....>>>>..>>...>>.>>>>>>...<.<<<<<<.....(((.....((.>>>)).......)))..>>>.>..>>>>>>>>>.....<<<((.....<<<<...<<..............<<<<<<.....<.<<<<<<.<<<......>>>..>>>>>>..>...........<<....>>.>>>>>>......>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<<.....))..>>>>>>>.>>>.<<<........<<....>>......>>>..>>>>>><<<<<.<<<<<<<...<<..<<<<<..<<<<<<<<<<.....<<........>>..........<<<<<<<..........<<<.<<<..<<<<<<.......<<..<<<<<....>>>.......>>..>>......<<.....>>..........>>>...>>>>>>>>>...>>>>>>>..>>.>>>>>>>>.....<<<<.....>>>>...........<....<<<<<<<......>>>>>>>....>.....>>>>>.....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<...<<<.<<..<<<<<..<<<.....<<<<.....>>>>....>>>.....>>>>>..>>.>>>....>.>>...>.....<<<<<<<<<....>>>>>>>>>........ [.[[[[..(((((..]]]]](((((((((..((((((((..(.(((.(((..((....))......(((.....(((((...(((((...)))))...))).)).(((....((..((((......))).)))......)))..(.....)))).(((....))).....)))))))......(..((...(((((....)))).))).).)).))))))...(.((([[[.....(((.....((.]]])).......)))..))).)..))))))))).....((([[...(.((((...((......(.......(((((((......((((((.((........))..))))))......).....(.((....)))))))))....).))...))))....((((((...((...((((.........))))...))))))))......{...(((((((.....]]..))))))))))).(((........((....))......)))...)))))(((((.(((((((...((..(((((..((((((((((.....((........))..........(((((((..(......).((.(((...((((((.(....((..(((((....))).......))..))......((.....))......).).)))...)).)))))....)))))))..)).)))))))).(...((((.....))))...........(....(((((((......)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(...(((.((..((((((.(((((...((((.....))))..)))))...).)))))..)).)))....).))...)..)..(((((((((....)))))))))}....... Structure of the small subunit of the mammalian mitoribosome; MITORIBOSOMAL 12S RRNA 5aj4 AA 960 3.8 RF00177,RF01959 URS00000CFF65_9823 25837512 0003735 0005840 9823 acagguuugguccuggccuuucuauuaauucuuaauaaaauuacacaugcaaguauccgcgccccggugagaaugcccuccagaucuuaaagaucaaaaggagcagguaucaagcacaccuauaacgguagcucauaacgccuugcucaaccacacccccacgggaaacagcagugauaaaaauuaagccaugaacgaaaguuugacuaaguuauauuaauuagaguugguaaaucucgugccagccaccgcggucauacgauuaacccaaauuaauagauccacggcguaaagaguguuuaagaaaaaaaaucacaauagaguuaaauuauaacuaagcuguaaaaagcccuaguuaaaauaaaauaacccacgaaagugacucuaauaauccugacacacgauagcuaggacccaaacugggauuagauaccccacuaugccuagcccuaaacccaaauaguuacauaacaaaacuauucgccagaguacuacucgcaacugccuaaaacucaaaggacuuggcggugcuucacauccaccuagaggagccuguucuauaaucgauaaaccccgauagaccuuaccaacccuugccaauucagccuauauaccgccaucuucagcaaacccuaaaaaggaacaauaguaagcacaaucauagcacauaaaaacguuaggucaagguguagcuuauggguuggaaagaaaugggcuacauuuucuacauaagaauauccaccacacgaaaguuuuuaugaaacuaaaaaccaaaggaggauuuagcaguaaaucaagaauagagugcuugauugaauaaggccaugaagcacgcacacaccgcccgucacccuccucaagcauguaguaauaaaaauaaccuauauucaauuacacaaccaugcaagaagagacaagucguaacaagguaagcauacuggaaagugugcuuggauuacc ..((((..<<<<<<.)))).<<<<<<<<<..<<<<<<<<..<.<<<.<<<..<<....>>......<<......<<<<<...<<<<<...>>>>>...>>>.>>.<<<....<<...<<<......>>>..>>......>>>..<.....>.>>.<<<....>>>.....>>>>>>>.........<<....<<<<....>>>>..>>...>>.>>>>>>...<.<<<<<<.....(((.....((.>>>)).......)))..>>>.>..>>>>>>>>>.....<<<((.....<<<<...<<..............<<<<<<.....<.<<<<<<.<<<......>>>..>>>>>>..>...........<<....>>.>>>>>>......>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<<.....))..>>>>>>>.>>>.<<<........<<....>>......>>>..>>>>>><<<<<.<<<<<<<...<<..<<<<<..<<<<<<<<<<.....<<........>>..........<<<<<<<..........<<<.<<<..<<<<<<.......<<..<<<<<....>>>.......>>..>>......<<.....>>..........>>>...>>>>>>>>>...>>>>>>>..>>.>>>>>>>>.....<<<<.....>>>>...........<....<<<<<<<......>>>>>>>....>.....>>>>>.....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<...<<<.<<..<<<<<<.<<<.....<<<<.....>>>>....>>>...>.>>>>>..>>.>>>....>.>>...>.....<<<<<<<<<....>>>>>>>>>........ [.[[[[..(((((..]]]]](((((((((..((((((((..(.(((.(((..((....))......(((.....(((((...(((((...)))))...))).)).(((....((..(((((...).))).)))......)))..(.....)))).(((....))).....)))))))......(..((...(((((....)))).))).).)).))))))...(.((([[[.....(((.....((.]]])).......)))..))).)..))))))))).....((([[...(.((((...((..............(((((((......((((((.((........))..))))))......).....(.((....)))))))))......))...))))....((((((...((...((((.........))))...))))))))......{...(((((((.....]]..))))))))))).(((........((....))......)))...)))))(((((.(((((((...((..(((((..((((((((((.....((........))..........(((((((..(......).((.(((...((((((.(....((..(((((....))).......))..))......((.....))......).).)))...)).)))))....)))))))..)).)))))))).(...((((.....))))...........(....(((((((......)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(...(((.((..(((((..(((((...((((.....))))..))))).....)))))..)).)))....).))...)..)..(((((((((....)))))))))}....... Structure of the 55S mammalian mitoribosome.; MITORIBOSOMAL 12S Ribosomal RNA 5aj4 BA 1515 3.8 RF02541,RF02540 URS000080E15B_9823 25837512 0003735 0005840 9823 accaaagcuagcucaacaacaaauacaaaaauacaccaaaauaaaauaaaacauucaccuaacauuaaaguauaggagauagaaauuuuuauccugacgcuauagagauaguaccguaagggaaagaugaaagaauaaaaguaaaaaaaagcaaagauuaccccuucuaccuuuugcauaaugguuuaaccagaaaaaaucuaacaaagagaacuuuagcuagauaccccgaaaccagacgagcuacccaugagcaguuuaaaagaaccaacucaucuauguggcaaaauagugagaagacuuguagguagaggugaaaagccuaacgagccuggugauagcugguuguccgagaaagaauuuuaguucaaccuuaaaaauaccccaaaaacccuaaauuccaauguauuuuuaagagauagucuaaaaagguacagcuuuuuagaaacggauacaaccuugacuagagaguaaaucuuaauacuaccauaguaggccuaaaagcagccaucaauugagaaagcguuaaagcucaacaaauucaccaacauaaucccaaaaacuaauaacaaacuccuagcccaauaccggacuaaucuauugaaacauagaagcaauaauguuaauaugaguaacaagaagccuuucuccucgcacacgcuuacaucaguaacuaauaauauacugauaauuaacaaccaauaaaccaaaacaacacuaaaacguuuauuaauuacauuguuaacccaacacaggagugcaccaaggaaagauuaaaagaaguaaaaggaacucggcaaacacaaaccccgccuguuuaccaaaaacaucaccucuagcauuacuaguauuagaggcaaugccugcccagugacaaguuuaacggccgcgguacugaccgugcaaagguagcauaaucacuuguucuccaaauaaggacuuguaugaauggccacacgaggguuuuacugucucuuacuuccaaucagugaaauuaaccuucccgugaagaggcgggaauaaaaaaauaagacgagaagacccuauggagcuuuaauuaacuauuccaaaaguucuuaacauggacuagcaauuucgguuggggugaccucggaguacaaaaaacccuccgagugauuuuaaucuagacaaaccagucaaaauaaucacuuauugauccaaaauuuugaucaacggaacaaguuacccuagggauaacagcgcaauccuguucuagaguuccuaucgacaauaggguuuacgaccucgauguuggaucaggacacccaaauggugcagccgcuauuaaagguucguuuguucaacgauuaaaguccuacgugaucugaguucagaccggagcaauccaggucgguuucuaucuauuauaaauuucucccaguacgaaaggacaagagaaaugggaccaaccucacaaacgcgucucagagauaauuaaugauuuaaucuuaaccuaauuaacucauaauaaauccagcccuagaacagggcaca <<........<<<<.................................<......>.................<<.....>>..............>>.>>.............<<....>>...................>>...........<<<.......>>>...<.<........>.>..<<<<<........<<<<<.<..<<....>>...>.>>>>>..<<.<..<<<<<.<.....<<<.<<<<<..<<<......>>>...<<<<.<<<<........>>>>>>>>....>>>>>.>>>...<<<.....>>>......>.>>>>...>..>.>>..<<<<<.....<<<<....>>>>...<<<<<<<<<<<.....<<........>>.....>>>>>>>>>>>......<<<<<<<<<......>>>>>>>>>...<<......>>....<<<<.<<<..................<....<<<.........>>>....>.......<<<......>>>........................................>>>>>>>........>>>>>...<<<<<......>>>>>.........>>>>>.<......<<..<<<<..>>>><<<<.<<<<........<<<<<....<<....>>..>>>>>......<<<..<<<<<<<.................>>>>>>>.......>>>.....<<......>>.>>>>....>>>>..<<<<....<<<<<<<.<<...............<<<<<<<<..<<<.........>>>...<<<<<<.............>>>>>>...<<<<.<<<..<<<<<..>>>..>>>>><<<<<<....>>>>>>........<...........<<<<<.......>>>>>.....>....>>>.>..>>.>>>>>>......>>.>>>>>>>.>>>>.>>.....>..(..<<<<<.......)>>>>>.......<<<.<<<.<<......<<<<.<<<<<<..<<<<..<<<.<<<<.<<<..>>>....>>>>.>>>.>>>>..<<<<.....>>>><<<<<<...........>>>>>>.<<<<....<<...<<<......>>>...>>.>>>>..........<<<<..>>>>............>>>>..>>>>>>.......<<<..<.<<<<<<...<<.......>>...>>>>>>...>.>>.>.......<<<<<.<<<<<<..<<.<<<<<<......>>>>>>...>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>>>>.<<.<<<<<<<.................>>>>>>><<<<<...............>>>>>.<<<...<<<<.................>>>>...>>>.>>.........<<<<.......>>>>... ((.(...(..((((.................................(...[..)........(..(.....((.]...))....)..)......)).)).............((....))....).........)....))...........(((.......))).[.(.(........).)..(((((........(((((.(..((....))...).)))))..((.(...((((.(.....(((.((((((.(((.....[)))...(((..((((.......{)))).)))..).))))).))).(.(((.....)))...)..).))))......).))..(((((.....((((....))))...(((((((((((.....((........)).....)))))))))))......(((((((((......)))))))))...((......))....((((.(((....................(..(((.........)))..)......(..(((......)))).......................................)))))))........)))))...(((((......))))).........))))).(......((..((((..))))(((..((((......(.(((((....((....))..)))))......(((..(((((((...........(..)..))))))).......))).)...((......)).)))).....)))..((((....(((((((.((..(....(.......((((((((.].((.........))....((((((.............))))))...((((.(((..(((((..)))..)))))((((........))))........((..........(((((.......)))))..)..)....))).)..)).))))))..)..))).))))))).)))).)).....)..{..(((((.....]}.))))).......(((.(((.((......((((.((((((..((((..(((.((((.((....))....)))).))).))))..(((......[)))((((((..........]))))))((((((..)((.(.(((...[..))))..)).))))..........(((....))).....)].....))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......((((.((((((..((.((((((......))))))...)).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..}.))..)))))).((.(((((((......(....).....)))))))(((((...(.(.....).).))))).(((....(((.................)))....))).)).........((((.......))))... Structure of the 55S mammalian mitoribosome.; MITORIBOSOMAL 16S Ribosomal RNA 5aka A 117 5.7 RF00001 URS0000049E57_83333 25775537 0003735 0005840 83333 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggc <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>> (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))) EM structure of ribosome-SRP-FtsY complex in closed state; 5S ribosomal RNA 5aka B 2841 5.7 RF02540,RF02541 URS00004B0F34_83333 25775537 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaacaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauggaaguguggacgccagucugcauggcuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((....<......<.<<<..<<<<<...<<<....<<..........>>.(.......<<<......)>>>...>>>.....>>>>>..>>>>....>..........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.<...<<<...<<<.<<<<.......>>>>.>>>..>>.>...>.>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<............<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>........>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>>....<<<....<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>....>>>........<<<........>>>....>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.......<<<<<..<<....>>...>>>>>.......>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<.....<<<<<<<<....>>>>>>>>....>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<<...>>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...(((...(........((..(((((((((.(((...(((((......)))))[[(...).((......]].))...)))...)))))))))..)).....).........((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((...(((((((((.(...(((...(((.((((.......)))).)))..)).)...).)))))).)))...))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(.(.(..(.(.......(((((.(((..(((.........)))..))).....(..(((......)))).)))))...).)..).).).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((..((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((((((((((...((((....((((..(((..(...((((((.....{{{....))))).....((....((((((((((((.((.....))))))))))..))))....))......(...((((....))))....))...)...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..).))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((((.(...(((((((......)))))))..).)))).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.((((((...))))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). EM structure of ribosome-SRP-FtsY complex in closed state; 23S ribosomal RNA 5amq B 16 3.0 URS0000868514_11577 26004069 11577 uugguaguacacuacu ................ ................ Structure of the La Crosse Bunyavirus polymerase in complex with the 3' and 5' viral RNA; RNA 5amr B 16 2.57 URS0000868514_11577 26004069 11577 uugguaguacacuacu ................ ................ Structure of the La Crosse Bunyavirus polymerase in complex with the 3' viral RNA; RNA 5apn 5 3112 3.91 RF02540,RF02543 URS00008FED50_559292 26709046 0003735 0005840 559292 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Structure of the yeast 60S ribosomal subunit in complex with Arx1, Alb1 and N-terminally tagged Rei1; 25S rRNA 5apn 7 121 3.91 RF00001 URS000055688D_559292 26709046 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<<............>>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Structure of the yeast 60S ribosomal subunit in complex with Arx1, Alb1 and N-terminally tagged Rei1; 5S rRNA 5apn 8 158 3.91 RF00002 URS00001BF64E_559292 26709046 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Structure of the yeast 60S ribosomal subunit in complex with Arx1, Alb1 and N-terminally tagged Rei1; 5.8S rRNA 5apo 5 3112 3.41 RF02540,RF02543 URS00008FED3D_559292 26709046 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacgggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggnnnnnnnnnnnnnnnnnnnnacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgcuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaauuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu 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........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((.(((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))).....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((......((((((....)))))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((....((.(((((((.....(((....(((..(.((((())))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((..(((((((...((.....)).))))))....[[(((.((...((....(((....)))........((((((((...)).))))))....))....))...(((((........)))))]]((((.((((.(((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....)))...)))))))).))).))).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((.(((((((((()))))))))).)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}..((.(((..((((((.(...(......((((....))))......).)))))..)))))()........(.(.........(((((.......)))))..)..).....))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..((.((.((((((((..(.((.)).)....((((.....((((..((((........))))...........>...((((((....))))))..))))..))))......))))))))..)).))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....)))).).))))).......((.(.(.((((((...((.......))...))))))...)).).).......(((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).))....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....))))))))..((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Structure of the yeast 60S ribosomal subunit in complex with Arx1, Alb1 and C-terminally tagged Rei1; 25S ribosomal RNA 5apo 7 121 3.41 RF00001 URS000055688D_559292 26709046 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Structure of the yeast 60S ribosomal subunit in complex with Arx1, Alb1 and C-terminally tagged Rei1; 5S ribosomal RNA 5apo 8 158 3.41 RF00002 URS00001BF64E_559292 26709046 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Structure of the yeast 60S ribosomal subunit in complex with Arx1, Alb1 and C-terminally tagged Rei1; 5.8S ribosomal RNA 5ay2 A 12 1.3 URS00008E394B_32630 26448329 32630 ggacungacucc ............ ............ Crystal structure of RNA duplex containing C-Ag(I)-C base pairs; RNA (5'-R(*GP*GP*AP*CP*UP*(CBR)P*GP*AP*CP*UP*CP*C)-3') 5ay2 B 12 1.3 URS00008E394B_32630 26448329 32630 ggacungacucc ............ ............ Crystal structure of RNA duplex containing C-Ag(I)-C base pairs; RNA (5'-R(*GP*GP*AP*CP*UP*(CBR)P*GP*AP*CP*UP*CP*C)-3') 5ay2 C 12 1.3 URS00008E394B_32630 26448329 32630 ggacungacucc ............ ............ Crystal structure of RNA duplex containing C-Ag(I)-C base pairs; RNA (5'-R(*GP*GP*AP*CP*UP*(CBR)P*GP*AP*CP*UP*CP*C)-3') 5ay2 D 12 1.3 URS00008E394B_32630 26448329 32630 ggacungacucc ............ ............ Crystal structure of RNA duplex containing C-Ag(I)-C base pairs; RNA (5'-R(*GP*GP*AP*CP*UP*(CBR)P*GP*AP*CP*UP*CP*C)-3') 5ay3 A 12 1.2 URS00008E394B_32630 26448329 32630 ggacungacucc ............ ............ Crystal structure of RNA duplex containing C-C base pairs; RNA (5'-R(*GP*GP*AP*CP*UP*(CBR)P*GP*A*CP*UP*CP*C)-3') 5ay3 B 12 1.2 URS00008E394B_32630 26448329 32630 ggacungacucc ............ ............ Crystal structure of RNA duplex containing C-C base pairs; RNA (5'-R(*GP*GP*AP*CP*UP*(CBR)P*GP*A*CP*UP*CP*C)-3') 5ay4 A 12 1.7 URS00008E394B_32630 26448329 32630 ggacungacucc ............ ............ Crystal structure of RNA duplex containing C-C base pairs obtained in the presence of Hg(II); RNA (5'-R(*GP*GP*AP*CP*UP*(CBR)P*GP*AP*CP*UP*CP*C)-3') 5ay4 B 12 1.7 URS00008E394B_32630 26448329 32630 ggacungacucc ............ ............ Crystal structure of RNA duplex containing C-C base pairs obtained in the presence of Hg(II); RNA (5'-R(*GP*GP*AP*CP*UP*(CBR)P*GP*AP*CP*UP*CP*C)-3') 5bjo E 36 2.35 URS0000BC4664_32630 28945234 32630 ggcgcgaggaaggaggucugaggaggucacugcgcc <<<<<..........................>>>>> (((((...(........).((.....))...))))) Crystal structure of the Corn RNA aptamer in complex with DFHO, site-specific 5-iodo-U; RNA (36-MER) 5bjo Y 36 2.35 URS0000BC4664_32630 28945234 32630 ggcgcgaggaaggaggucugaggaggucacugcgcc <<<<<..........................>>>>> (((((...(........).(.......)...))))) Crystal structure of the Corn RNA aptamer in complex with DFHO, site-specific 5-iodo-U; RNA (36-MER) 5bjp E 36 2.51 URS0000BC4664_32630 28945234 32630 ggcgcgaggaaggaggucugaggaggucacugcgcc <<<<<..........................>>>>> (((((...(........).(.......)...))))) Crystal structure of the Corn RNA aptamer in complex with DFHO, iridium hexammine soak; RNA (36-MER) 5bjp Y 36 2.51 URS0000BC4664_32630 28945234 32630 ggcgcgaggaaggaggucugaggaggucacugcgcc <<<<<..........................>>>>> (((((...(........).((.....))...))))) Crystal structure of the Corn RNA aptamer in complex with DFHO, iridium hexammine soak; RNA (36-MER) 5bkl e 11 2.94 URS0000B21DE7_12881 34866603 12881 uuuuuuuuuuu ........... ........... Crystallographic structure of the cubic crystal form of STMV (77.9 degree rotation) grown from NaCl; RNA (5'-R(*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*U)-3') 5bkl WW 10 2.94 URS0000B21DE7_12881 34866603 12881 uuuuuuuuuu .......... .......... Crystallographic structure of the cubic crystal form of STMV (77.9 degree rotation) grown from NaCl; RNA (5'-R(*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*U)-3') 5bkl bb 11 2.94 URS0000A7631E_12881 34866603 12881 aaaaaaaaaaa ........... ........... Crystallographic structure of the cubic crystal form of STMV (77.9 degree rotation) grown from NaCl; RNA (5'-R(*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 5bkn e 11 3.0 URS000080DF9E_12881 34866603 12881 uuuuuuuuuuu ........... ........... Crystallographic structure of a cubic crystal form of STMV (84.5 degree rotation) grown from chloride; RNA (5'-R(P*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*U)-3') 5bkn bb 11 3.0 URS0000A7631E_12881 34866603 12881 aaaaaaaaaaa ........... ........... Crystallographic structure of a cubic crystal form of STMV (84.5 degree rotation) grown from chloride; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 5bs3 E 20 2.65 URS0000868560_681288 25851938 681288 agccgtagggccctacggct .................... .................... Crystal Structure of S.A. gyrase in complex with Compound 7; DNA/RNA (5'-R(P*AP*GP*CP*CP*G)-D(P*T)-R(P*AP*GP*GP*GP*CP*CP*C)-D(P*T)-R(P*AP*CP*GP*GP*C)-D(P*T)-3') 5bs3 F 19 2.65 URS0000868560_681288 25851938 681288 agccgtagggccctacggc ................... ................... Crystal Structure of S.A. gyrase in complex with Compound 7; DNA/RNA (5'-R(P*AP*GP*CP*CP*G)-D(P*T)-R(P*AP*GP*GP*GP*CP*CP*C)-D(P*T)-R(P*AP*CP*GP*GP*C)-D(P*T)-3') 5c45 X 54 2.93 RF00050 URS000080DF4D_851 26416753 0010181 851 ggaucuucggggcagggugaaauucccgaccggugguauaguccacgaaagcuu ..............<<<.......>>>.....<<<<......>>>>........ ..............(((.......))).....((((......))))........ Selective Small Molecule Inhibition of the FMN Riboswitch; FMN Riboswitch 5c45 Y 56 2.93 RF00050 URS000080E20B_851 26416753 0010181 851 gcuuugauuuggugaaauuccaaaaccgacaguagagucuggaugagagaagauuc .......<<<<<.......>>>>>.....<<<......>>>............... .......(((((.......))))).....(((......)))............... Selective Small Molecule Inhibition of the FMN Riboswitch; FMN Riboswitch 5c5w A 19 1.25 URS0000868524_4930 26457524 4930 ccugaguucaauucuagcg ................... ................... 1.25 A resolution structure of an RNA 20-mer; RNA (5'-R(P*CP*CP*UP*GP*AP*GP*UP*UP*CP*AP*AP*UP*UP*CP*UP*AP*GP*CP*G)-3') 5c9h D 10 3.0 URS0000868554_5911 26436828 5911 agaacuguca .......... .......... Structural Basis of Template Boundary Definition in Tetrahymena Telomerase; RNA (5'-R(P*AP*GP*AP*AP*CP*UP*GP*UP*CP*A)-3') 5c9h C 12 3.0 URS000086851F_5911 26436828 5911 ucauucaguucu ............ ............ Structural Basis of Template Boundary Definition in Tetrahymena Telomerase; RNA (5'-R(P*UP*CP*AP*UP*UP*CP*AP*GP*UP*UP*CP*U)-3') 5c9h E 10 3.0 URS0000868554_5911 26436828 5911 gaacugucau .......... .......... Structural Basis of Template Boundary Definition in Tetrahymena Telomerase; RNA (5'-R(P*AP*GP*AP*AP*CP*UP*GP*UP*CP*A)-3') 5c9h G 11 3.0 URS000086851F_5911 26436828 5911 cauucaguucu ........... ........... Structural Basis of Template Boundary Definition in Tetrahymena Telomerase; RNA (5'-R(P*UP*CP*AP*UP*UP*CP*AP*GP*UP*UP*CP*U)-3') 5cnr A 16 2.59 URS00008FED23_390157 26914842 390157 gucuacccaccucgcc ................ ................ Crystal structure-guided design of self-assembling RNA nano triangles; RNA (5'-R(*GP*UP*CP*UP*AP*CP*CP*CP*AP*CP*CP*UP*CP*GP*CP*C)-3') 5cnr B 11 2.59 URS00008FED31_390157 26914842 390157 agaggacggcg ........... ........... Crystal structure-guided design of self-assembling RNA nano triangles; RNA (5'-R(*AP*GP*AP*GP*GP*AP*CP*GP*GP*CP*G)-3') 5cnr E 16 2.59 URS00008FED23_390157 26914842 390157 gucuacccaccucgcc ................ ................ Crystal structure-guided design of self-assembling RNA nano triangles; RNA (5'-R(*GP*UP*CP*UP*AP*CP*CP*CP*AP*CP*CP*UP*CP*GP*CP*C)-3') 5cnr F 11 2.59 URS00008FED31_390157 26914842 390157 agaggacggcg ........... ........... Crystal structure-guided design of self-assembling RNA nano triangles; RNA (5'-R(*AP*GP*AP*GP*GP*AP*CP*GP*GP*CP*G)-3') 5czp YA 2867 3.29996 RF02540,RF02541,RF00002 URS00001698E8_300852 27681416 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<.......>>>....>>......................>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<.......<<<<<<......>>>>>>....>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((..))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((.(.((((((......)))).)))..)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......(((((.(((..(((.......)))...))).....(...(........).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))(((((((())))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((.(.((((.(.........(((((..(((.......((((.((....)).))))....)))............)))))).)))).).)))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))((((.))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) 70S termination complex containing E. coli RF2; 23S rRNA 5czp YB 120 3.29996 RF00001 URS00005F2F4B_300852 27681416 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). 70S termination complex containing E. coli RF2; 5S rRNA 5czp XA 1504 3.29996 RF00177,RF01959,RF01960 URS000080DFED_300852 27681416 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<..<<<<<<<<....>>>>>>>>..>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>....<<<....>>>...>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((..(((((((((..)))))))))..)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((...(((((((....))))))).(..(((....)))..).)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.... 70S termination complex containing E. coli RF2; 16S rRNA 5czp QA 1500 3.29996 RF00177,RF01959,RF01960 URS000080DFED_300852 27681416 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<.<......>.>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((..)))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((((((....)))))))...((((....))))...)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.... 70S termination complex containing E. coli RF2; 16S rRNA 5czp RA 2867 3.29996 RF02540,RF02541,RF00002 URS00001698E8_300852 27681416 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<.......>>>....>>.......<............>.>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<.......<<<<<<......>>>>>>....>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((..))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((.(.((((((......)))).)))..)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((.(.......(((((.(((..(((.......)))...))).....(...(........).).)))))...).)))))))).))..........]]].)....))))))))))...)))))))(((((((())))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((.(.((((.(.........(((((..(((........(((.(......).))).....)))............)))))).)))).).)))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))((((.))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) 70S termination complex containing E. coli RF2; 23S rRNA 5czp RB 120 3.29996 RF00001 URS00005F2F4B_300852 27681416 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>. .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). 70S termination complex containing E. coli RF2; 5S rRNA 5czp QV 77 3.29996 RF00005 URS000041AF00_511145 27681416 0030533 0006412 511145 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(.(.(..]....).).)))))))..... 70S termination complex containing E. coli RF2; P-site tRNA fMet 5czp XV 77 3.29996 RF00005 URS000041AF00_511145 27681416 0030533 0006412 511145 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<.........>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((.(..]....).)))))))))..... 70S termination complex containing E. coli RF2; P-site tRNA fMet 5d8b UC 1504 3.63 RF00177,RF01959,RF01960 URS000086852E_262724 26412335 0003735 0005840 262724 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgaggaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<...<..<<<.<<<..<<<..<<.<<<<<<<<<.......>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>...>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<......>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<...<<<.....>>>.>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((((((((.......))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....((((....(....((((.....)))).....).....))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((.((...)).)))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((.(((..(((.(((....))).)))...((((....))))..))).))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(....(((.....)))..)...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Crystal structure of T. thermophilus ribosome containing a P-site wobble mismatch; 16S ribosomal RNA 5d8b VC 2879 3.63 RF02540,RF02541,RF00002 URS000056A434_262724 26412335 0003735 0005840 262724 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgucuaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcucaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaaaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagcuccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagacgacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.....>>>>>>.>>....<<<<<.....<......>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<....<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.....>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<<.....>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> ((.......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...((((((((.....))))))))....[.(((((((((......(...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)..)))))).))))....(((((((((.{.....)))))))))....].(((((}.[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((.(((((.(...(((((((((....((...(((.((((.(.((((((......)))).)))..)))).)))..)).....)))))))))..)..))))).).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((..((..(((.........)))..)).......................)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.((...{{....))))))(((...((((((((((((((((.((.....)))))))))....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).((((......))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((...........(((((..(((.......((((((......))))))....)))............)))))..))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....((((((..((..]]]]..)).)))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))...................(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...)))).....)) Crystal structure of T. thermophilus ribosome containing a P-site wobble mismatch; 23S ribosomal RNA 5d8b WC 119 3.63 RF00001 URS000039883D_262724 26412335 0003735 0005840 262724 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).)))))))))) Crystal structure of T. thermophilus ribosome containing a P-site wobble mismatch; 5S ribosomal RNA 5d8b XC 77 3.63 RF00005 URS000041AF00_562 26412335 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(.(((..]....))).)))))))..... Crystal structure of T. thermophilus ribosome containing a P-site wobble mismatch; tRNA 5d8b YC 1504 3.63 RF00177,RF01959,RF01960 URS000086852E_262724 26412335 0003735 0005840 262724 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgaggaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<...<..<<<.<<<..<<<..<<.<<<<<<<<<.......>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>...>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<......>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<...<<<.....>>>.>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((((((((.......))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....((((....(....((((.....)))).....).....))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((.((...)).)))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((.(((..(((.(((....))).)))...((((....))))..))).))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(....(((.....)))..)...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Crystal structure of T. thermophilus ribosome containing a P-site wobble mismatch; 16S ribosomal RNA 5d8b ZC 2879 3.63 RF02540,RF02541,RF00002 URS000056A434_262724 26412335 0003735 0005840 262724 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgucuaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcucaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaaaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagcuccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagacgacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.....>>>>>>.>>....<<<<<.....<......>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<....<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.....>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<<.....>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> ((.......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...((((((((.....))))))))....[.(((((((((......(...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)..)))))).))))....(((((((((.{.....)))))))))....].(((((}.[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((.(((((.(...(((((((((....((...(((.((((.(.((((((......)))).)))..)))).)))..)).....)))))))))..)..))))).).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((..((..(((.........)))..)).......................)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.((...{{....))))))(((...((((((((((((((((.((.....)))))))))....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).((((......))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((...........(((((..(((.......((((((......))))))....)))............)))))..))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....((((((..((..]]]]..)).)))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))...................(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...)))).....)) Crystal structure of T. thermophilus ribosome containing a P-site wobble mismatch; 23S ribosomal RNA 5d8b AD 119 3.63 RF00001 URS000039883D_262724 26412335 0003735 0005840 262724 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).)))))))))) Crystal structure of T. thermophilus ribosome containing a P-site wobble mismatch; 5S ribosomal RNA 5d8b BD 77 3.63 RF00005 URS000041AF00_562 26412335 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(.(((..]....))).)))))))..... Crystal structure of T. thermophilus ribosome containing a P-site wobble mismatch; tRNA 5d8b ED 77 3.63 RF00005 URS000041AF00_562 26412335 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of T. thermophilus ribosome containing a P-site wobble mismatch; tRNA 5d8b FD 77 3.63 RF00005 URS000041AF00_562 26412335 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of T. thermophilus ribosome containing a P-site wobble mismatch; tRNA 5da6 A 32 1.05 URS00008FED44_5691 27050127 5691 agagaagaaagggaaauuuuuuuuuuuuuuuu ................................ ................................ Atomic resolution crystal structure of double-stranded RNA 32 base pairs long determined from random starting phases angles in the presence of pseudo translational symmetry using the direct methods program SIR2014.; RNA (32-MER) 5dat 2 1781 3.15 RF01960,RF01959,RF00177 URS00005F2C2D_559292 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucau ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[..................<.....<<.<<<.....>>>.>>......>.........<<<<<..<......>..>>>>>[...((((((......<<<<<<<<<<......>>..............)))))).....]...<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<...<<.<..........>.>>....>>>......<<..<...........>..>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..))))))]]]].........[[[{{.......{{...[[[.[[....<<<<<<.<<<<<....<..>....>>>>>.>>>>>>....<<<<<<...............................>>>>>>....<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>..........[[...((((((((....>>>>>>>>.))))))))..]].....]]....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>......<<<....>>>..>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<.......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>>....>.>>>>>....>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<.<<<..<<..................>>..>>>.>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>....... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((............)))))(.(.((((((......[[[[[[[[(((....))).....(......).)))))).)...).(.((((..((.(....))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((....(((.}...)))..)))).)....).).....((....(((...(....)...))).....))......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((.(.....().....).))).))))))....((((((..........(.........)..........))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(....(.((.(((....]]]]]]]].))).)).)...).....))...(((..((.((...((((..((..((((((.....((........))........))))))..))......(((....)))..))))..)).))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...((..................................))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>...... Complex of yeast 80S ribosome with hypusine-containing eIF5A; 18S ribosomal RNA 5dat 1 3149 3.15 RF02540,RF02543 URS000061F377_559292 0003735 0005840 559292 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Complex of yeast 80S ribosome with hypusine-containing eIF5A; 25S ribosomal RNA 5dat 3 121 3.15 RF00001 URS000055688D_559292 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Complex of yeast 80S ribosome with hypusine-containing eIF5A; 5S ribosomal RNA 5dat 4 158 3.15 RF00002 URS00001BF64E_559292 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Complex of yeast 80S ribosome with hypusine-containing eIF5A; 5.8S ribosomal RNA 5dat 6 1795 3.15 RF01960,RF01959,RF00177 URS00005F2C2D_559292 0003735 0005840 559292 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...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[...............<.....<<.<<.......>>.>>......>.........<<<<<..<......>..>>>>>....((((((......<<<<<<<<<<<<..>>>>..............)))))).........<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<<<<.<..........>.>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.{{....<<<<<<.<<<..<<<<...............>>>>......>>>.>>>>>>....<<<<<<....<<..<<<<.......>>>>..>>....>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[[..((((((((....>>>>>>>>.)))))))).]]].....}}....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<......<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<<<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>...>.>>>>>>>.......>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<.<<<..<<.......>>...>>>.>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... 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Complex of yeast 80S ribosome with hypusine-containing eIF5A; 18S ribosomal RNA 5dat 5 3169 3.15 RF02540,RF02543 URS000061F377_559292 0003735 0005840 559292 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Complex of yeast 80S ribosome with hypusine-containing eIF5A; 25S ribosomal RNA 5dat 7 121 3.15 RF00001 URS000055688D_559292 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Complex of yeast 80S ribosome with hypusine-containing eIF5A; 5S ribosomal RNA 5dat 8 158 3.15 RF00002 URS00001BF64E_559292 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Complex of yeast 80S ribosome with hypusine-containing eIF5A; 5.8S ribosomal RNA 5dc3 2 1781 3.25 RF01960,RF01959,RF00177 URS00005F2C2D_559292 27196944 0003735 0005840 559292 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...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[..................<.....<<.<<<.....>>>.>>......>.........<<<<<..<......>..>>>>>[...((((((......<<<<<<<<<<......>>..............)))))).....]...<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<.<<.<..........>.>>.>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.[[....<<<<<<.<<<<<....<..>....>>>>>.>>>>>>....<<<<<<...............................>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[...((((((((....>>>>>>>>.))))))))..]].....]]....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>......<<<....>>>..>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>>....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<.<<...<.........>....>>.>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>....... 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Complex of yeast 80S ribosome with non-modified eIF5A; 18S ribosomal RNA 5dc3 1 3149 3.25 RF02540,RF02543 URS000061F377_559292 27196944 0003735 0005840 559292 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Complex of yeast 80S ribosome with non-modified eIF5A; 25S ribosomal RNA 5dc3 3 121 3.25 RF00001 URS000055688D_4932 27196944 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Complex of yeast 80S ribosome with non-modified eIF5A; 5S ribosomal RNA 5dc3 4 158 3.25 RF00002 URS00001BF64E_4932 27196944 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Complex of yeast 80S ribosome with non-modified eIF5A; 5.8S ribosomal RNA 5dc3 6 1795 3.25 RF01960,RF01959,RF00177 URS00005F2C2D_559292 27196944 0003735 0005840 559292 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...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[...............<.....<<.<<.......>>.>>......>.........<<<<<..<<....>>..>>>>>[...((((((......<<<<<<<<<<<<..>>>>....<<......>>)))))).....]...<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<<<<.<..........>.>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.{{....<<<<<<.<<<..<<<<...............>>>>......>>>.>>>>>>....<<<<<<....<<..<<<<.......>>>>..>>....>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[[..((((((((....>>>>>>>>.)))))))).]]].....}}....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<.<....>.>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<.......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<<<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>...>.>>>>>>>.....>.>>>>>....>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<.<<<................>>>.>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... 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Complex of yeast 80S ribosome with non-modified eIF5A; 18S ribosomal RNA 5dc3 5 3169 3.25 RF02540,RF02543 URS000061F377_559292 27196944 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacauggcugggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauagagggcuaccuuuauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<.<<<<<.<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>.>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<<...........<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<<..<<<<<<.....>>>>>>>>>>>....>>>..>>.>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<<.....>.>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<.....<..>......>>>>><<.<<<<<<<<<<<..>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<..<<<....<<<<<....>>>>.>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<..<<<<.<.....>>>>>...>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<......>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<<...<<<<<<<<<<}}}.>>>>>..>>>>>..>>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((.(.(((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..)))).).)....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((...........(((((((((((((((((((((((.......(((((((......((((((....)))))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...(.(.((.....)).).).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.......(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((..((((((....((.....))..)))))....[[(((.((...((....(((....)))........(.(..(.(...)..)..).)....))....))...(((((........)))))]]((((.((((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....))))..)))))))).))).))).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((..)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...(......((((....))))......).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..((((((((......(.((...))).......))))))))....((((.....((((..((((........))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).).......(((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).))....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.............))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Complex of yeast 80S ribosome with non-modified eIF5A; 25S ribosomal RNA 5dc3 7 121 3.25 RF00001 URS000055688D_4932 27196944 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<<............>>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Complex of yeast 80S ribosome with non-modified eIF5A; 5S ribosomal RNA 5dc3 8 158 3.25 RF00002 URS00001BF64E_4932 27196944 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Complex of yeast 80S ribosome with non-modified eIF5A; 5.8S ribosomal RNA 5dfe QV 77 3.09998 RF00005 URS000041AF00_562 27681416 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<.........>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(.(.(..]....).).)))))))..... 70S termination complex containing E. coli RF2; P-site tRNA fMet 5dfe QX 10 3.09998 27681416 32630 aaauguaaca .......... .......... 70S termination complex containing E. coli RF2; messenger RNA 5dfe XV 77 3.09998 RF00005 URS000041AF00_562 27681416 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<.........>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((.(..]....).)))))))))..... 70S termination complex containing E. coli RF2; P-site tRNA fMet 5dfe XX 10 3.09998 27681416 32630 aaauguaaca .......... .......... 70S termination complex containing E. coli RF2; messenger RNA 5dfe YA 2867 3.09998 RF02540,RF02541,RF00002 URS00001698E8_300852 27681416 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..<<<.......>>>...>>>......................>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<.<<<<<......>>>>>>....>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((..))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...((((((((.(.((((((......)))).)))..))))))))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((........((((.((...(((.......)))....)).....(...((......)).).))))....)))))))))).))..........]]].)....))))))))))...)))))))(((((((())))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((.(.((((.(......[..(((((..(((........(((.((....)).))).....)))..........].)))))).)))).).)))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))((((.))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) 70S termination complex containing E. coli RF2; T23S rRNA 5dfe YB 120 3.09998 RF00001 URS00005F2F4B_300852 27681416 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). 70S termination complex containing E. coli RF2; 5S rRNA 5dfe XA 1504 3.09998 RF00177,RF01959,RF01960 URS000080DFED_300852 27681416 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>.....<......>....>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((((((....))))))).(..(((....)))..).)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.... 70S termination complex containing E. coli RF2; 16S rRNA 5dfe QA 1500 3.09998 RF00177,RF01959,RF01960 URS000080DFED_300852 27681416 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<.<......>.>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((..)))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((((((....)))))))...((((....))))...)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.... 70S termination complex containing E. coli RF2; 16S rRNA 5dfe RA 2867 3.09998 RF02540,RF02541,RF00002 URS00001698E8_300852 27681416 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..<<<.......>>>...>>>......................>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<.<<<<<......>>>>>>....>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((..))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((.(.((((((......)))).)))..)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((........((((.((...(((.......)))....)).....(...(........).).))))....)))))))))).))..........]]].)....))))))))))...)))))))(((((((())))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((.(.((((.(......[..(((((..(((........(((.(......).))).....)))..........].)))))).)))).).)))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))((((.))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) 70S termination complex containing E. coli RF2; T23S rRNA 5dfe RB 120 3.09998 RF00001 URS00005F2F4B_300852 27681416 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>. .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). 70S termination complex containing E. coli RF2; 5S rRNA 5dge 2 1781 3.45 RF01960,RF01959,RF00177 URS00005F2C2D_559292 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucau ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[..................<.....<<.<<.......>>.>>......>.........<<<<<..<......>..>>>>>[...((((((......<<<<<<<<.<......>...............)))))).....]...<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<..<.<..........>.>..>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.[[....<<<<<<.<<<<<....<..>....>>>>>.>>>>>>....<<<<<<...........<.......>...........>>>>>>....<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>..........[[...((((((((....>>>>>>>>.))))))))..]].....]]....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<......>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>......<....<<<<<<..........>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<..<<...<.........>....>>..>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>....... 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Coping with proline stalling: structural basis of hypusine-induced protein synthesis by the eukaryotic ribosome; 18S ribosomal RNA 5dge 1 3149 3.45 RF02540,RF02543 URS000061F377_559292 0003735 0005840 559292 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Complex of yeast 80S ribosome with hypusine-containing/non-modified eIF5A and/or a peptidyl-tRNA analog; 18S ribosomal RNA 5dgf 1 3149 3.3 RF02540,RF02543 URS000061F377_559292 0003735 0005840 559292 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Complex of yeast 80S ribosome with hypusine-containing/non-modified eIF5A and/or a peptidyl-tRNA analog; 25S ribosomal RNA 5dgf 3 121 3.3 RF00001 URS000055688D_559292 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Complex of yeast 80S ribosome with hypusine-containing/non-modified eIF5A and/or a peptidyl-tRNA analog; 5S ribosomal RNA 5dgf 4 158 3.3 RF00002 URS00001BF64E_559292 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Complex of yeast 80S ribosome with hypusine-containing/non-modified eIF5A and/or a peptidyl-tRNA analog; 5.8S ribosomal RNA 5dgf 6 1795 3.3 RF01960,RF01959,RF00177 URS00005F2C2D_559292 0003735 0005840 559292 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Complex of yeast 80S ribosome with hypusine-containing/non-modified eIF5A and/or a peptidyl-tRNA analog; 18S ribosomal RNA 5dgf 5 3169 3.3 RF02540,RF02543 URS000061F377_559292 0003735 0005840 559292 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Complex of yeast 80S ribosome with hypusine-containing/non-modified eIF5A and/or a peptidyl-tRNA analog; 25S ribosomal RNA 5dgf 7 121 3.3 RF00001 URS000055688D_559292 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Complex of yeast 80S ribosome with hypusine-containing/non-modified eIF5A and/or a peptidyl-tRNA analog; 5S ribosomal RNA 5dgf 8 158 3.3 RF00002 URS00001BF64E_559292 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Complex of yeast 80S ribosome with hypusine-containing/non-modified eIF5A and/or a peptidyl-tRNA analog; 5.8S ribosomal RNA 5dgv 2 1781 3.1 RF01960,RF01959,RF00177 URS00005F2C2D_559292 0003735 0005840 559292 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Complex of yeast 80S ribosome with hypusine-containing/non-modified eIF5A and/or a peptidyl-tRNA analog; Saccharomyces cerevisiae S288c RDN37-1 miscRNA 5dgv 1 3148 3.1 RF02540,RF02543 URS000061F377_559292 0003735 0005840 559292 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Complex of yeast 80S ribosome with hypusine-containing/non-modified eIF5A and/or a peptidyl-tRNA analog; 25S ribosomal RNA 5dgv 3 121 3.1 RF00001 URS000055688D_559292 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Complex of yeast 80S ribosome with hypusine-containing/non-modified eIF5A and/or a peptidyl-tRNA analog; 5S ribosomal RNA 5dgv 4 158 3.1 RF00002 URS00001BF64E_559292 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((...(.]].)..........).)))..)...)))....((.....))(((((((((....)))))))))..................... Complex of yeast 80S ribosome with hypusine-containing/non-modified eIF5A and/or a peptidyl-tRNA analog; 5.8S ribosomal RNA 5dgv 6 1795 3.1 RF01960,RF01959,RF00177 URS00005F2C2D_559292 0003735 0005840 559292 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Complex of yeast 80S ribosome with hypusine-containing/non-modified eIF5A and/or a peptidyl-tRNA analog; Saccharomyces cerevisiae S288c RDN37-1 miscRNA 5dgv 5 3149 3.1 RF02540,RF02543 URS000061F377_559292 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacauggcugggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagagacccuguugagcuugacucuaguuugacauugugaagagacguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..<<<..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<<.<<<<.<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>.>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<<...........<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<<..<<<<<<.....>>>>>>>>>>>....>>>..>>.>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<<.....>.>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..[[[..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<....>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<..<<<....<<<<<....>>>>.>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<.....<<<<.<<<<<<..<<<<<.<<<<<<<<..<<<<<<........>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<......>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))......<<<<<<<..<<<<.))))))>>>>>>>>>>>.........>>>>..>>>>>>.......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<<]]].>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<.<..<<<<<......>>>>>..>>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((..((((..((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))......)))).))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((...........(((((((((((((((((((((((.......(((((((......((((((....)))))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.(((((..(.((((.....)))).)))))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.......(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((..((((((....((.....))..)))))....[[(((.((...((....(((....)))........(.(....(...).....).)....))....))...(((((........)))))]]((((.((((((.(...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....).))..)))))))).))).))).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((((....))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...(......((((....))))......).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((.....((((.((((((..(((((.((((((((..(.((............)).)....((((.....((((..(.((........)).)...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.............))))...)))).))))....)))))))).......(((.((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).)).)))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(((.((..)..).)))..)))))...)))....)))).)))))).))))).. Complex of yeast 80S ribosome with hypusine-containing/non-modified eIF5A and/or a peptidyl-tRNA analog; 25S ribosomal RNA 5dgv 7 121 3.1 RF00001 URS000055688D_559292 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<<............>>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Complex of yeast 80S ribosome with hypusine-containing/non-modified eIF5A and/or a peptidyl-tRNA analog; 5S ribosomal RNA 5dgv 8 158 3.1 RF00002 URS00001BF64E_559292 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Complex of yeast 80S ribosome with hypusine-containing/non-modified eIF5A and/or a peptidyl-tRNA analog; 5.8S ribosomal RNA 5dh6 A 48 2.784 RF00008 URS000086852D_32630 26398724 3.1.-.- 0004540 32630 ggguacuuaagcccacugaugagucgcugggaugcgacaaaacgccca ......................<<<<<......>>>>>.......... ...............(....).(((((......))))).......... Two divalent metal ions and conformational changes play roles in the hammerhead ribozyme cleavage reaction-G12A mutant in Mg2+; hammerhead ribozyme 5dh6 B 20 2.784 URS000086855A_32630 26398724 32630 gggcgucugggcaguaccca .................... .................... Two divalent metal ions and conformational changes play roles in the hammerhead ribozyme cleavage reaction-G12A mutant in Mg2+; 5'-R(*GP*GP*GP*CP*GP*U)-D(P*C)-R(P*UP*GP*GP*GP*CP*AP*GP*UP*AP*CP*CP*CP*A)-3' 5dh7 A 48 3.064 RF00008 URS000086852D_32630 26398724 3.1.-.- 0004540 32630 ggguacuuaagcccacugaugagucgcugggaugcgacaaaacgccca ......................<<<<<......>>>>>.......... ...............(....).(((((......))))).......... Two divalent metal ions and conformational changes play roles in the hammerhead ribozyme cleavage reaction-G12A mutant in Mn2+; RNA (48-MER) 5dh7 B 20 3.064 URS000086855A_32630 26398724 32630 gggcgucugggcaguaccca .................... .................... Two divalent metal ions and conformational changes play roles in the hammerhead ribozyme cleavage reaction-G12A mutant in Mn2+; 5'-R(*GP*GP*GP*CP*GP*UP*DC*UP*GP*GP*GP*CP*AP*GP*UP*AP*CP*CP*CP*A)-3' 5dh8 A 48 3.297 RF00008 URS000086852D_32630 26398724 3.1.-.- 0004540 32630 ggguacuuaagcccacugaugagucgcugggaugcgacaaaacgccca ......................<<<<<......>>>>>.......... ...............(....).(((((......))))).......... Two divalent metal ions and conformational changes play roles in the hammerhead ribozyme cleavage reaction- G12A mutant in Zn2+; RNA (48-MER) 5dh8 B 20 3.297 URS000086855A_32630 26398724 32630 gggcgucugggcaguaccca .................... .................... Two divalent metal ions and conformational changes play roles in the hammerhead ribozyme cleavage reaction- G12A mutant in Zn2+; 5'-R(*GP*GP*GP*CP*GP*U)-D(P*C)-R(P*UP*GP*GP*GP*CP*AP*GP*UP*AP*CP*CP*CP*A)-3' 5dhc A 14 1.55 URS0002681414_32630 28058281 32630 nnnnacuuaagucu .............. .............. Cooperativity and Downstream Binding in RNA Replication; RNA (5'-R(*(LCC)P*(LCC)P*(LCA)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*U)-3') 5dhc B 14 1.55 URS0002681414_32630 28058281 32630 nnnnacuuaagucu .............. .............. Cooperativity and Downstream Binding in RNA Replication; RNA (5'-R(*(LCC)P*(LCC)P*(LCA)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*U)-3') 5dhc C 14 1.55 URS0002681414_32630 28058281 32630 nnnnacuuaagucu .............. .............. Cooperativity and Downstream Binding in RNA Replication; RNA (5'-R(*(LCC)P*(LCC)P*(LCA)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*U)-3') 5dhc D 14 1.55 URS0002681414_32630 28058281 32630 nnnnacuuaagucu .............. .............. Cooperativity and Downstream Binding in RNA Replication; RNA (5'-R(*(LCC)P*(LCC)P*(LCA)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*U)-3') 5di2 A 48 2.989 RF00008 URS0000868531_32630 26398724 3.1.-.- 0004540 32630 ggguacuuaagcccacugaugagucgcugggaugcgacgaaacgccca ......................<<<<<......>>>>>.......... ...............(....).(((((......))))).......... Two divalent metal ions and conformational changes play roles in the hammerhead ribozyme cleavage reaction-WT ribozyme in Mn2+ at high pH; RNA (48-MER) 5di2 B 20 2.989 URS000086855A_32630 26398724 32630 gggcgucugggcaguaccca .................... .................... Two divalent metal ions and conformational changes play roles in the hammerhead ribozyme cleavage reaction-WT ribozyme in Mn2+ at high pH; 5'-R(*GP*GP*GP*CP*GP*U)-D(P*C)-R(P*UP*GP*GP*GP*CP*AP*GP*UP*AP*CP*CP*CP*A)-3' 5di4 A 48 2.948 RF00008 URS0000868531_32630 26398724 3.1.-.- 0004540 32630 ggguacuuaagcccacugaugagucgcugggaugcgacgaaacgccca ......................<<<<<......>>>>>.......... ...............(....).(((((......))))).......... Two divalent metal ions and conformational changes play roles in the hammerhead ribozyme cleavage reaction-WT ribozyme in Mn2+ at low pH; RNA (48-MER) 5di4 B 20 2.948 URS000086855A_32630 26398724 32630 gggcgucugggcaguaccca .................... .................... Two divalent metal ions and conformational changes play roles in the hammerhead ribozyme cleavage reaction-WT ribozyme in Mn2+ at low pH; 5'-R(*GP*GP*GP*CP*GP*U)-D(P*C)-R(P*UP*GP*GP*GP*CP*AP*GP*UP*AP*CP*CP*CP*A)-3' 5dm6 X 2780 2.9 RF02540,RF02541 URS00008FED45_1299 26464437 0003735 0005840 1299 ggucaagauaguaaggguccacgguggaugcccuggcgcuggagccgaugaaggacgcgauuaccugcgaaaagccccgacgagcuggagauacgcuuugacucggggauguccgaauggggaaacccaccucguaagagguauccgcaaggaugggaacucagggaacugaaacaucucaguaccugaaggagaagaaagagaauucgauuccguuaguagcggcgagcgaacccggaucagcccaaucaagccgaaguggcuggaaagcuacaccucagaaggugagaguccuguaggcgaacgagaggucguuguucgugaaacgaugacugaauccgcgcggaccaccgcgcaaggcuaaauacucccagugaccgauagcgcauaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaagagaaccugaaaccguggacuuacaagcagucauggcaccuuaugcguguuauggcgugccuauugaagcaugagccggcgacuuagaccugacgugcgagcuuaaguugaaaaacggaggcggagcgaaagcgaguccgaauagggcggcauuaguacgucgggcuagacucgaaaccaggugagcuaagcaugaccagguugaaacccccgugacagggggcggaggaccgaaccggugccugcugaaacagucucggaugaguuguguuuaggagugaaaagcuaaccgaaccuggagauagcuaguucuccccgaaauguauugagguacagccucggauguugaccauguccuguagagcacucacaaggcuaaaaccuuaugaaacuccgaaggggcacgcguuuaguccgggagugaggcugcgagagcuaacuuccguagccgagagggaaacaacccagaccaucagcuaaggucccuaaaugaucgcucagugguuaaggaugugucgucgcauagacagccaggagguuggcuuagaagcagccacccuucaaagagugcguaauagcucacuggucgagugacgaugcgccgaaaaugaucggggcucaagugaucuaccgaagcuauggauucaacucgcgaagcgaguugucugguaggggagcguucaguccgcggagaagccauaccggaaggagugguggagccgacugaagugcggaugccggcaugaguaacgauaaaagaagugagaaucuucuucgccguaaggacaaggguuccuggggaagggucguccgcccagggaaagucgggaccuaaggugaggccgaacggcgcagccgauggacagcaggucaagauuccugcaccgaucauguggagugauggagggacgcauuacgcuauccaaugccaagcuauggcuaugcugguugguacgcucaagggcgaucgggucagaaaaucuaccggucacaugccucagacguaucgggagcuuccucggaagcgaaguuggaaacgcgacggugccaagaaaagcuucuaaacguugaaacaugauugcccguaccgcaaaccgacacagguguccgagugucaaugcacuaaggcgcgcgagagaacccucguuaaggaacuuugcaaucucaccccguaacuucggaagaagggguccccacgcuucgcguggggcgcagugaauaggcccaggcgacuguuuaccaaaaucacagcacucugccaacacgaacaguggacguauagggugugacgccugcccggugccggaaggucaaguggagcggugcaagcugcgaaaugaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaggcguaacgaucugggcgcugucucaacgagggacucggugaaauugaauuggcuguaaagaugcggccuacccguagcaggacgaaaagaccccguggagcuuuacuauagucuggcauugggauucggguuucucugcguaggauaggugggagccugcgaaacuggccuuuuggggucgguggaggcaacggugaaauaccacccugagaaacuuggauuucuaaccugaaaaaucacuuucggggaccgugcuuggcggguaguuugacuggggcggucgccucccaaaauguaacggaggcgcccaaaggucaccucaagacgguuggaaaucgucuguagagcgcaaagguagaagguggcuugacugcgagacugacacgucgagcagggaggaaacucgggcuuagugaaccggugguaccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagaguccauaucggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgcuacgggcgcaggagaauugaggggaguugcuccuaguacgagaggaccggagugaacggaccgcuggucucccugcugucguaccaacggcacaugcaggguagcuauguccggaacggauaaccgcugaaagcaucuaagcgggaagccagccccaagaugaguucucccacuguuuaucagguaagacucccggaagaccaccggguuaagaggccaggcgugcacgcauagcaauguguucagcggacuggugcucaucagucgaggucuugacca <<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<...<<.))..))..>>......>>>>>>...>>>....<<<....>>><<<<<....>>>>><<<<....>>>>>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<......<<.....>>.....>>>>...<<<...<<..<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>....>>..<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>..............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<.......>>>>>>>>>>...<.<........>.>.<<<<<<....<<<.<<<<<<<<<<..<<<...<<<....>>>...>>>...<<....>>...<<......>>.........>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<.....<<<<<......>>>>>......>>>...<<<..<.<<........>>.>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<...<<<..<<<<<<...<<<...<<<.<<<<......>>>>.>>>..>>.>...>>>>>>...>>>..>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..<<<<.......>>>>..>>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><..<<<<<<<<...>>>>>>>>..>....>>>>>><.<<<<<<<.<<......<<<<<.<<....>>.>>>>>...>>.>>>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<<..>>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<...<<...<<<<....<<<<..<<<..<<<<<.<<<<.<<..[[[....>>>>>><<<<<<<.<<..<<<<<<<<<<...<<.....>>.>>>>>>....>>>>..>>>>>>>>>...<<<<<....>>>>>....>>>>>...>>>...>>>>.........>>>>...>>......>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<...>>>>>>>>............<<<<<<<<<..<<...........>>..<<<<<<<.....<<<.....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>>.<<<<<.......>>>>>.........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<........<..<........>..>.....>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<<........>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.]]]>>>>>>...>>>>>...>>>>.>>>>>....<<....<<<<<...........>>>>>....>>..>>>>.......>>>>>>>..<<<.....>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>>>. ((((((((......((((((((((.....(((..((((((((((((......((((((.[...[[.))).....((((((...((.]]...]..))......))))))...)))....(((....)))(((((....)))))((((....))))))...((((((.....(...[..)......))))).).........((....))...((((......((.]...)).....))))...(((...((..(((...(((((......)))))[[(...).(((.....]])))...)))....))..(((((((((.[.....)))))))))......(((((].[[[[)))))..)))......)).)))))).))..............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.[..).)))))))))).<.(.(........).).((((((....(((.((((((((((..(((...(((....)))...)))...((....))...((......)).........)))))))))))))..((.(...((((((.....((((((((((..(((....(((((......)))))....)<))....(((..(.((........)).).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((...((((.((((((...(((....((.((((......)))).))...)).)...)))))).).)))..))))))).))..(((((((.((......)).)))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((.(.......(((((.(((..(((.........)))..))).....(...((......)).).)))))...).)))))))).))..........]]].)....))))))))))...)))))))(..((((((((...))))))))..)....))))))(.(((((((.((......(((((.((....))])))))...)).)))))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((((((...((...((((....(((((.(((..(((((.((((.((...{{....))))))(((((((.((..((((((((((...((.....)).))))))....))))..)))))))))...(((((....)))))....)))))...)))..)))))(..).....))))...))......))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.[..).....)))))((((((((...))))))))(...).......(((((((((.>.(...........)...(((((((.....(((.....))).......))))))).]((((.(((..(((((((..((....((...(((((....)))))...))....)))))))..)))))..((((.......))))..........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).[..(((((.....>].)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((.((((((((((.(.........(.(((..(((.......(...(........)...)....)))............))).)).)))))))))).)))))...((((((.......).)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...)..(][.[[[).....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....((.((((.((..]]]]..)))))).)).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))....((....((((.............))))....))..))))..]....)))))))(.(((.....)))....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))...))))))))). Crystal structure of the 50S ribosomal subunit from Deinococcus radiodurans; 23S ribosomal RNA 5dm6 Y 122 2.9 RF00001 URS000080E31C_1299 26464437 0003735 0005840 1299 cacccccgugcccauagcacuguggaaccaccccaccccaugccgaacugggucgugaaacacagcagcgccaaugauacucggaccgcagggucccggaaaagucggucagcgcggggguu .<<<<<<<<<<.....<<.<<<<<....<<<<<<<.............>>>>..>>>...>>>>>..>><<<.......<<.<<<<<....>>>>>.>>.......>>>..>>>>>>>>>>. .((((((((((.....((.(((((....(((((((...(.....)...))))..)))...)))))..))(((.......((.(((((....))))).)).......)))..)))))))))). Crystal structure of the 50S ribosomal subunit from Deinococcus radiodurans; 5S ribosomal RNA 5dm7 X 2780 3.0 RF02540,RF02541 URS00008FED45_1299 26464437 0003735 0005840 1299 ggucaagauaguaaggguccacgguggaugcccuggcgcuggagccgaugaaggacgcgauuaccugcgaaaagccccgacgagcuggagauacgcuuugacucggggauguccgaauggggaaacccaccucguaagagguauccgcaaggaugggaacucagggaacugaaacaucucaguaccugaaggagaagaaagagaauucgauuccguuaguagcggcgagcgaacccggaucagcccaaucaagccgaaguggcuggaaagcuacaccucagaaggugagaguccuguaggcgaacgagaggucguuguucgugaaacgaugacugaauccgcgcggaccaccgcgcaaggcuaaauacucccagugaccgauagcgcauaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaagagaaccugaaaccguggacuuacaagcagucauggcaccuuaugcguguuauggcgugccuauugaagcaugagccggcgacuuagaccugacgugcgagcuuaaguugaaaaacggaggcggagcgaaagcgaguccgaauagggcggcauuaguacgucgggcuagacucgaaaccaggugagcuaagcaugaccagguugaaacccccgugacagggggcggaggaccgaaccggugccugcugaaacagucucggaugaguuguguuuaggagugaaaagcuaaccgaaccuggagauagcuaguucuccccgaaauguauugagguacagccucggauguugaccauguccuguagagcacucacaaggcuaaaaccuuaugaaacuccgaaggggcacgcguuuaguccgggagugaggcugcgagagcuaacuuccguagccgagagggaaacaacccagaccaucagcuaaggucccuaaaugaucgcucagugguuaaggaugugucgucgcauagacagccaggagguuggcuuagaagcagccacccuucaaagagugcguaauagcucacuggucgagugacgaugcgccgaaaaugaucggggcucaagugaucuaccgaagcuauggauucaacucgcgaagcgaguugucugguaggggagcguucaguccgcggagaagccauaccggaaggagugguggagccgacugaagugcggaugccggcaugaguaacgauaaaagaagugagaaucuucuucgccguaaggacaaggguuccuggggaagggucguccgcccagggaaagucgggaccuaaggugaggccgaacggcgcagccgauggacagcaggucaagauuccugcaccgaucauguggagugauggagggacgcauuacgcuauccaaugccaagcuauggcuaugcugguugguacgcucaagggcgaucgggucagaaaaucuaccggucacaugccucagacguaucgggagcuuccucggaagcgaaguuggaaacgcgacggugccaagaaaagcuucuaaacguugaaacaugauugcccguaccgcaaaccgacacagguguccgagugucaaugcacuaaggcgcgcgagagaacccucguuaaggaacuuugcaaucucaccccguaacuucggaagaagggguccccacgcuucgcguggggcgcagugaauaggcccaggcgacuguuuaccaaaaucacagcacucugccaacacgaacaguggacguauagggugugacgccugcccggugccggaaggucaaguggagcggugcaagcugcgaaaugaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaggcguaacgaucugggcgcugucucaacgagggacucggugaaauugaauuggcuguaaagaugcggccuacccguagcaggacgaaaagaccccguggagcuuuacuauagucuggcauugggauucggguuucucugcguaggauaggugggagccugcgaaacuggccuuuuggggucgguggaggcaacggugaaauaccacccugagaaacuuggauuucuaaccugaaaaaucacuuucggggaccgugcuuggcggguaguuugacuggggcggucgccucccaaaauguaacggaggcgcccaaaggucaccucaagacgguuggaaaucgucuguagagcgcaaagguagaagguggcuugacugcgagacugacacgucgagcagggaggaaacucgggcuuagugaaccggugguaccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagaguccauaucggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgcuacgggcgcaggagaauugaggggaguugcuccuaguacgagaggaccggagugaacggaccgcuggucucccugcugucguaccaacggcacaugcaggguagcuauguccggaacggauaaccgcugaaagcaucuaagcgggaagccagccccaagaugaguucucccacuguuuaucagguaagacucccggaagaccaccggguuaagaggccaggcgugcacgcauagcaauguguucagcggacuggugcucaucagucgaggucuugacca <<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<<[...((>>>>.....<<<<<<...<<.))...]..>>......>>>>>>...>>>....<<<....>>><<<<<....>>>>><<<<....>>>>>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<......<<.....>>.....>>>>...<<<...<<..<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>....>>..<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>..............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<.......>>>>>>>>>>...<.<........>.>.<<<<<<....<<<.<<<<<<<<<<..<<<...<<<....>>>...>>>...<<....>>...<<......>>.........>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<.....<<<<<......>>>>>......>>>...<<<..<.<<........>>.>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<...<<<..<<<<<<....<<...<<<.<<<<......>>>>.>>>..>>.....>>>>>>...>>>..>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..<<<<.......>>>>..>>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><..<<<<<<<.....>>>>>>>..>....>>>>>>..<<<<<<<.<<......<<<<<.<<....>>.>>>>>...>>.>>>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<<..>>>>...>>>...>>....<<<<........>>>>.))<<<<<<<<<...<....<<<<....<<<<..<<<..<<<<<.<<<<.<<..[[[....>>>>>><<<<<<<.<<..<<<<<<<<<<...<<.....>>.>>>>>>....>>>>..>>>>>>>>>...<<<<<....>>>>>....>>>>>...>>>...>>>>.........>>>>....>......>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<...>>>>>>>>............<<<<<<<<<..<<...........>>..<<<<<<<.....<<<.....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>>.<<<<<.......>>>>>.........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<...<<<......<<<.<<<......>>>.>>>...>>>.............>>>>..>>>>>>>>>>>>>>>>...<<<.<<........>>.>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<.<<<.<.<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>...>...>>>..>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.]]]>>>>>>...>>>>>...>>>>.>>>>>....<<....<<<<<...........>>>>>....>>..>>>>.......>>>>>>>..<<<.....>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>>>. ((((((((......(.((((((((.....(((..((((((((((((......((((((.[...[[.)))....(((((((...((.]]...]..))......)))))).).)))....(((....)))(((((....)))))((((....))))))...((((((.....(...[..)......))))).).........((....))...((((......((.]...)).....))))...(((...((..(((...(((((......)))))[[(...).(((.....]])))...)))....))..((((((((..[......))))))))......(((((].[[[[)))))..)))......)).)))))).))..............((....))....))......(..((((....))))............)).....)))))))).).....(.(((((((((((.{..).)))))))))).[.(.(........).).((((((....(((.((((((((((...((...(((....)))...))....((....))...((......)).........)))))))))))))..((.(...((((((.....((((((((((..(((....(((((......)))))....)[))....(((..(.((........)).).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((.(((...((((.((((((...(((...(((.((((......)))).)))..)).)...)))))).).)))..))).))).))..(((((((.(........).)))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......(((((.(((..(((.........)))..))).........((......))...)))))...)))))))))).))..........]]].)....))))))))))...)))))))...(((((.((...)).))))).......))))))(.(((((((.((.......((((.((....))}))))....)).)))))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((((((....(...((((....(((((.(((..(((((.((((..(...{{....).))))(((((((.((..((((((((((....(.....)..))))))....))))..)))))))))....((((....)))).....)))))...)))..)))))(..).....))))...).......))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((...............)))))((((((((...))))))))(...).......(((((((((.].(...........)...(((((((.....(((.....))).......)))))))..((((.(((..(((((((..((....((...((((......))))...))....)))))))..)))))..((.(.......).))..........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....))....(((((.....]..)))))..((((((((.(((.........((((.((((((..(((((.(((.(((((.(((((.(.((((((((.(.........(.(((..(.(...........(........)........).)............))).)).)))))))).).)))))...(((.((........)).)))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...)..(][..[[).....)))))))...((((..(((...{..)))..)))).(((....))).))].].].....((.((((.((..]]]]..)))))).)).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))........)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))....((....((((.............))))....))..))))..]....)))))))(.(((.....)))....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))...))))))))). Crystal structure of the 50S ribosomal subunit from Deinococcus radiodurans in complex with hygromycin A; 23S ribosomal RNA 5dm7 Y 122 3.0 RF00001 URS000080E31C_1299 26464437 0003735 0005840 1299 cacccccgugcccauagcacuguggaaccaccccaccccaugccgaacugggucgugaaacacagcagcgccaaugauacucggaccgcagggucccggaaaagucggucagcgcggggguu .<<<<<<<<<<.....<<.<<<<<....<<<<<<<.............>>>>..>>>...>>>>>..>><<<.......<<.<<<<<....>>>>>.>>.......>>>..>>>>>>>>>>. ..(((((((((.....((.(((((....((((((....(.....)....)))..)))...)))))..))(((.......((.(((((....))))).)).......)))..))))))))).. Crystal structure of the 50S ribosomal subunit from Deinococcus radiodurans in complex with hygromycin A; 5S ribosomal RNA 5do5 A 12 1.2 URS000080E0B7_32630 32630 cgcgaauunncg ............ ............ Crystal Structure of 2'-Fluoro-RNA bearing a phosphorodithioate; RNA (5'-R(*CP*GP*CP*GP*AP*AP*UP*UP*(AF2)P*(2SG)P*CP*G)-3') 5dox 1A 2872 3.1 RF02540,RF02541,RF00002 URS00001698E8_300852 26028538 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<...<<<.......>>>...>>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>>....<<<..>>>......>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<......>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((..(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((..)))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((.(.((((..........)).)))..)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((.((((((.(......[..(((((..(((......(((((.((....)).)))))...)))..........].)))))).)))))).)))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..((((.))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with Hygromycin-A at 3.1A resolution; 23S Ribosomal RNA 5dox 1B 120 3.1 RF00001 URS000080DEE8_300852 26028538 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the Thermus thermophilus 70S ribosome in complex with Hygromycin-A at 3.1A resolution; 5S Ribosomal RNA 5dox 1a 1500 3.1 RF00177,RF01959,RF01960 URS000080DFED_300852 26028538 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<.......<<<<<<<..<<<<<<<....>>>>>>>...<<........>>..>>>>>>>..<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((..((..(((..((.((((.(((..))).)))).)))))......(((......((((((((..((...(((((((.(((((.....(((((....)))))......)))))....((((..((((....))))..))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)).))).).....(.(((...(.(((....)))..))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((.(.((((((((((......((((((.....))))))....))))))))..))).)))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((.((...)).)))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((...((((((......))))))...((........))...)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))).[)).)))))))).....(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....).....))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the Thermus thermophilus 70S ribosome in complex with Hygromycin-A at 3.1A resolution; 16S Ribosomal RNA 5dox 2A 2867 3.1 RF02540,RF02541,RF00002 URS00001698E8_300852 26028538 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu 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.((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((..))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((.(.((((((......)))).)))..)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......(((((.((....................)).........((......))...)))))...)))))))))).))..........]]].)....))))))))))...)))))))(((((((())))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((.((((((.(.........(((((..(((.......((((((......))))))....)))............)))))).)))))).)))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(((...)).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...))). Crystal structure of the Thermus thermophilus 70S ribosome in complex with Hygromycin-A at 3.1A resolution; 23S Ribosomal RNA 5dox 2B 120 3.1 RF00001 URS000080DEE8_300852 26028538 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the Thermus thermophilus 70S ribosome in complex with Hygromycin-A at 3.1A resolution; 5S Ribosomal RNA 5dox 2a 1504 3.1 RF00177,RF01959,RF01960 URS000080DFED_300852 26028538 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<.<<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>.....<......>....>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((.(.((((((((((......((((((.....))))))....))))))))..))).)))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((.(((((((...))))))).))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.((((((...(...(((((((...(((((((....))))))).(..(((....)))..).)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...))))))).....(((((....)))))........)))).....).).)))...)).))))).....))))))).[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the Thermus thermophilus 70S ribosome in complex with Hygromycin-A at 3.1A resolution; 16S Ribosomal RNA 5doy 1A 2871 2.6 RF02540,RF02541,RF00002 URS00001698E8_300852 26028538 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<.....<<<<......>>>>......>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<.....(.>>>....>>.........<<......>>.).>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<.<<....>>.>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<.<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>..>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...((((((((.....))))))))....{.(((((((((..(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).))))....(((((((((.[.....)))))))))....}.(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...((((((((....(((.(......).))..)...))))))))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((..((.........))...))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((.(((((((((.(......[..(((((..(((......(((((.((....)).)))))...)))..........].)))))).))))))))).))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..(((...)))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with antibiotic Hygromycin A, mRNA and three tRNAs in the A, P and E sites at 2.6A resolution; 23S Ribosomal RNA 5doy 1B 120 2.6 RF00001 URS000080DEE8_300852 26028538 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the Thermus thermophilus 70S ribosome in complex with antibiotic Hygromycin A, mRNA and three tRNAs in the A, P and E sites at 2.6A resolution; 5S Ribosomal RNA 5doy 1a 1500 2.6 RF00177,RF01959,RF01960 URS000080DFED_300852 26028538 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>.....<......>....>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((((((.().))))))).)))))......(((......((((((((..((...(((((((.(((((....(.((((....)))).).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((.(((....))).)))....(((....)))....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the Thermus thermophilus 70S ribosome in complex with antibiotic Hygromycin A, mRNA and three tRNAs in the A, P and E sites at 2.6A resolution; 16S Ribosomal RNA 5doy 1v 14 2.6 26028538 10665 aaaaauguucuaau .............. .............. Crystal structure of the Thermus thermophilus 70S ribosome in complex with antibiotic Hygromycin A, mRNA and three tRNAs in the A, P and E sites at 2.6A resolution; mRNA 5doy 1w 75 2.6 RF00005 URS00005AA258_562 26028538 0030533 0006412 562 gcccgganagcucagcgguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<.......>>>><<<<<<<.....>>>>>>.>...<<<<<.......>>>>>>>>>>>>.... (((((((..((((....[..)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with antibiotic Hygromycin A, mRNA and three tRNAs in the A, P and E sites at 2.6A resolution; A-site and E-site tRNAs 5doy 1x 76 2.6 RF00005 URS000041AF00_562 26028538 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with antibiotic Hygromycin A, mRNA and three tRNAs in the A, P and E sites at 2.6A resolution; P-site tRNA 5doy 1y 74 2.6 RF00005 URS00005AA258_562 26028538 0030533 0006412 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((......)))).((((.........)))).....(((((.......)))))))))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with antibiotic Hygromycin A, mRNA and three tRNAs in the A, P and E sites at 2.6A resolution; A-site and E-site tRNAs 5doy 2A 2800 2.6 RF02540,RF02541,RF00002 URS00001698E8_300852 26028538 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<....<<<<<......>>>>.>....>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<..>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<...<<......<<<<<<<<....>>>>>>>>...>>.............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((...))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((()))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((((((.....(.(..........)..).....)))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((((((..))))))))).))..........]]].)....))))))))))...)))))))(((((((())))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........(((((...((.......((((.((....)).))))....)).............)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.((((...........))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....))))))).(((.))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with antibiotic Hygromycin A, mRNA and three tRNAs in the A, P and E sites at 2.6A resolution; 23S Ribosomal RNA 5doy 2B 120 2.6 RF00001 URS000080DEE8_300852 26028538 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> .((((((((((....((((((.(....(((((((...(.....)...))))..)))...).)))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the Thermus thermophilus 70S ribosome in complex with antibiotic Hygromycin A, mRNA and three tRNAs in the A, P and E sites at 2.6A resolution; 5S Ribosomal RNA 5doy 2a 1503 2.6 RF00177,RF01959,RF01960 URS000080DFED_300852 26028538 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggau .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>....<<.....>>....>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((.(..).)))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((((..(((((((....)))))))...(..(....)..)..))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}... Crystal structure of the Thermus thermophilus 70S ribosome in complex with antibiotic Hygromycin A, mRNA and three tRNAs in the A, P and E sites at 2.6A resolution; 16S Ribosomal RNA 5doy 2v 13 2.6 26028538 10665 aaaaauguucuaa ............. ............. Crystal structure of the Thermus thermophilus 70S ribosome in complex with antibiotic Hygromycin A, mRNA and three tRNAs in the A, P and E sites at 2.6A resolution; mRNA 5doy 2w 74 2.6 RF00005 URS00005AA258_562 26028538 0030533 0006412 562 cccgganagcucagcgguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<..<<<<.......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((....[..)))).((((.........)))).....(((((..]....)))))))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with antibiotic Hygromycin A, mRNA and three tRNAs in the A, P and E sites at 2.6A resolution; A-site and E-site tRNAs 5doy 2x 76 2.6 RF00005 URS000041AF00_562 26028538 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with antibiotic Hygromycin A, mRNA and three tRNAs in the A, P and E sites at 2.6A resolution; P-site tRNA 5doy 2y 73 2.6 RF00005 URS00005AA258_562 26028538 0030533 0006412 562 gcccgganagcucagggagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<.....>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[.)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with antibiotic Hygromycin A, mRNA and three tRNAs in the A, P and E sites at 2.6A resolution; A-site and E-site tRNAs 5dqk A 48 2.707 RF00008 URS0000868531_32630 26398724 3.1.-.- 0004540 32630 ggguacuuaagcccacugaugagucgcugggaugcgacgaaacgccca ......................<<<<<......>>>>>.......... ...............(....).(((((......))))).......... Two divalent metal ions and conformational changes play roles in the hammerhead ribozyme cleavage reaction-WT ribozyme in Mg2+; RNA (48-MER) 5dqk B 20 2.707 URS000086855A_32630 26398724 32630 gggcgucugggcaguaccca .................... .................... Two divalent metal ions and conformational changes play roles in the hammerhead ribozyme cleavage reaction-WT ribozyme in Mg2+; RNA (5'-R(*GP*GP*GP*CP*GP*U)-D(P*C)-R(P*UP*GP*GP*GP*CP*AP*GP*UP*AP*CP*CP*CP*A)-3') 5dv7 A 18 3.5 URS00008FED1F_32630 26712564 32630 ccagcauuaugaaaguga .................. .................. Crystal Structure of NF90 tandem dsRBDs with dsRNA; RNA (5'-R(*CP*CP*AP*GP*CP*AP*UP*UP*AP*UP*GP*AP*AP*AP*GP*UP*GP*A)-3') 5dv7 B 18 3.5 URS00008FED2B_32630 26712564 32630 ucacuuucauaaugcugg .................. .................. Crystal Structure of NF90 tandem dsRBDs with dsRNA; RNA (5'-R(*UP*CP*AP*CP*UP*UP*UP*CP*AP*UP*AP*AP*UP*GP*CP*UP*GP*G)-3') 5e3h B 12 2.7 URS000080E1F4_32630 21947008 32630 cgacgcuagcgu ............ ............ Structural Basis for RNA Recognition and Activation of RIG-I; RNA (5'-R(*CP*GP*AP*CP*GP*CP*UP*AP*GP*CP*GP*U)-3') 5e3h C 12 2.7 URS000080E1F4_32630 21947008 32630 acgcuagcgucg ............ ............ Structural Basis for RNA Recognition and Activation of RIG-I; RNA (5'-R(*CP*GP*AP*CP*GP*CP*UP*AP*GP*CP*GP*U)-3') 5e7k 13 1496 3.2 RF00177,RF01959,RF01960 URS0000868551_300852 26791911 0003735 0005840 300852 uuuuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggacacc .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<......>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>....<<......>>...>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>....... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(.(..((.(........).)).))......(((......((((((((..((...(((((((.(((((....((((........)))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((((..((((((......)))))).................))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((....(..(((.....)))).....)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}...... Structure of T. thermophilus 70S ribosome complex with mRNA and cognate tRNALys in the A-site; 16S rRNA 5e7k 1K 71 3.2 RF00005 URS00008FED39_562 26791911 0030533 0006412 562 gggucguuagcucaguggagcaguugacunuunaucaauugucgcaggnucgaauccugcacgacccacca <<<<<<...<<<<....>>>>.<<<<<.......>>>>>......<<<.......>>>...>>>>>>.... (((((.(..((((...[)))).((((.........)))).......((..]....))...).))))).... Structure of T. thermophilus 70S ribosome complex with mRNA and cognate tRNALys in the A-site; tRNALys 5e7k 2K 77 3.2 RF00005 URS000041AF00_562 26791911 0030533 0006412 562 cgcggggnggagcagccugguagcucgucgggnucauaacccgaagnucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Structure of T. thermophilus 70S ribosome complex with mRNA and cognate tRNALys in the A-site; tRNAfMet 5e7k 3K 76 3.2 RF00005 URS000042DDAB_562 26791911 0030533 0006412 562 gggucguuagcucaguugguagagcaguugacuuuuaaucaauuggucgcagguucgaauccugcacgacccacca <<<<<<...<<<<........>>>>.<<<<<.......>>>>>......<<<<.......>>>>..>>>>>>.... (((......((((........)))).(((((.......)))))......(((.........))).....))).... Structure of T. thermophilus 70S ribosome complex with mRNA and cognate tRNALys in the A-site; tRNALys 5e7k 4K 19 3.2 26791911 562 ggagguaaaaaugaaaaaa ................... ................... Structure of T. thermophilus 70S ribosome complex with mRNA and cognate tRNALys in the A-site; mRNA 5e7k 1H 2833 3.2 RF02540,RF02541,RF00002 URS0000868533_300852 26791911 0003735 0005840 300852 aagaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaacgggggccgaaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuaggggccuccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucuu <<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.....>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....<<.....>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<.<.<.<...>.>>..>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<..................>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<......>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<..<...<<......<<<<<<<<....>>>>>>>>...>>..............>.>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<.........>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>> 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Structure of T. thermophilus 70S ribosome complex with mRNA and cognate tRNALys in the A-site; 23S rRNA 5e7k 16 122 3.2 RF00001 URS00005AB4A7_300852 26791911 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga ..<<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> ..(((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).))))))))))) Structure of T. thermophilus 70S ribosome complex with mRNA and cognate tRNALys in the A-site; 5S rRNA 5e7k 1G 1507 3.2 RF00177,RF01959,RF01960 URS0000868551_300852 26791911 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucacc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<<..>>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<.......<<<<<<<..<<<<<<<....>>>>>>>....<<......>>...>>>>>>>...<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>....>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>........ .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((())))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([....(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((...])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(....(((.(((....(((((....)))))......((......))...))).))).).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.((((((...(....(((.....)))..)....)))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..(...((((....))))...)....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((..........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}....... Structure of T. thermophilus 70S ribosome complex with mRNA and cognate tRNALys in the A-site; 16S rRNA 5e7k 1L 73 3.2 RF00005 URS000042DDAB_562 26791911 0030533 0006412 562 gggucguuagcucaguuggugagcaguugacunuunaucaauugcgcaggnucgaauccugcacgacccacca <<<<<<<..<<<<...(...>>>>.<<<<<.......>>>>>...<<<<<...)...>>>>>>>>>>>>.... ((........(((.......)))..(.((.........)).)...(.(((.......))).).....)).... Structure of T. thermophilus 70S ribosome complex with mRNA and cognate tRNALys in the A-site; tRNALys 5e7k 2L 77 3.2 RF00005 URS000041AF00_562 26791911 0030533 0006412 562 cgcggggnggagcagccugguagcucgucgggnucauaacccgaagnucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Structure of T. thermophilus 70S ribosome complex with mRNA and cognate tRNALys in the A-site; tRNAfMet 5e7k 3L 76 3.2 RF00005 URS000042DDAB_562 26791911 0030533 0006412 562 gggucguuagcucaguugguagagcaguugacuuuuaaucaauuggucgcaggnucgaauccugcacgacccacca .<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .(((.((..((((........))))..(((.........)))......(..((.......))..))).)))..... Structure of T. thermophilus 70S ribosome complex with mRNA and cognate tRNALys in the A-site; tRNALys 5e7k 4L 18 3.2 26791911 562 ggagguaaaaaugaaaaa .................. .................. Structure of T. thermophilus 70S ribosome complex with mRNA and cognate tRNALys in the A-site; mRNA 5e7k 14 2861 3.2 RF02540,RF02541,RF00002 URS0000868533_300852 26791911 0003735 0005840 300852 ggucaagaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaacggcgaaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuaggaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcggacagccaggauguuggaagcagccaagagugcgagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcuaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucuugacc ..............<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<....>>>>>.>>....<<<<<.....<......>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>..............>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<....<<...<<<<<<<<...........>>>>>>>>..>>.....>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<.....<...<<...............................>>..>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<..<<..<<......<<<<<<<<<..>>>>>>>>>...>>............>>.>...>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<.............>>>>....>>>.>>>>.......>>>>>>>...<<.......>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>............ 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Structure of T. thermophilus 70S ribosome complex with mRNA and cognate tRNALys in the A-site; 23S rRNA 5e7k 1J 122 3.2 RF00001 URS00005AB4A7_300852 26791911 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga ..<<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>>> ...((((((((((....((((((.(....(((((((...(.....)...))))..)))...).)))).))(((.......((.(((((....))))).)).......))).)))))))))). Structure of T. thermophilus 70S ribosome complex with mRNA and cognate tRNALys in the A-site; 5S rRNA 5e81 13 1496 2.95 RF00177,RF01959,RF01960 URS00008FED22_300852 26791911 0003735 0005840 300852 uuuuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggacacc .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<......>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>.................>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<..<.<<<<<<<........>>>>>>>>...>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>....... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(........).)))))......(((......((((((((..((...(((((((.(.(((....(((((......))))).....))).)....(.((.(.(((....))).).)).)...((.(...).)).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((((..(((((((....))))))).................))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}...... Structure of T. thermophilus 70S ribosome complex with mRNA and tRNALys in the A-site with wobble pair; 16S ribosomal RNA 5e81 1K 72 2.95 RF00005 URS000042DDAB_562 26791911 0030533 0006412 562 gggucguuagcucagugagagcaguugacunuunaucaauugucgcaggnucgaauccugcacgacccacca <<<<<<...<<<<.....>>>>.<<<<<.......>>>>>.....<<<<.......>>>>..>>>>>>.... ..(...(..((((...[.)))).((((.........))))......(((..]....)))..)...)...... Structure of T. thermophilus 70S ribosome complex with mRNA and tRNALys in the A-site with wobble pair; tRNA-Lys 5e81 2K 77 2.95 RF00005 URS000057545F_300852 26791911 0030533 0006412 300852 cgcggggnggagcagcccgguagcucgucgggnucauaacccgaagnucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Structure of T. thermophilus 70S ribosome complex with mRNA and tRNALys in the A-site with wobble pair; tRNA-fMet 5e81 3K 70 2.95 RF00005 URS000042DDAB_300852 26791911 0030533 0006412 300852 gggucguuagcucagugagcaguugacuuuuaaucaauuggcgcagguucgaauccugcacgacccacca <<<<.<<...<<<...>>>..<<<<<.......>>>>>.....<<<<.......>>>>.>>.>>>>.... (((..(....(((...)))..(((((.......))))).......(.........)....)..))).... Structure of T. thermophilus 70S ribosome complex with mRNA and tRNALys in the A-site with wobble pair; tRNA-Lys 5e81 4K 21 2.95 26791911 562 ggagguaaaaaugaagaaaaa ..................... ..................... Structure of T. thermophilus 70S ribosome complex with mRNA and tRNALys in the A-site with wobble pair; mRNA 5e81 1H 2885 2.95 RF02540,RF02541,RF00002 URS0000868533_300852 26791911 0003735 0005840 300852 aagaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaacgggggccgaaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuaggggccuccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggauguuggcuuagaagcagccaucauuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucuu <<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.....>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....<<.....>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<...>>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<......>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<.<<<<<<<<<...........<<..<<..<<......<<<<<<<<....>>>>>>>>...>>.............>>.>>..>>>>>>>>>.>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<<..<<.......>>>..>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<.........>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>> .(((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....((.....))....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((.(.((.(.).)))..)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......(.(((..((..(.(.........).)..))......(...((......)).).))).)...)))))))))).))..........]]].)....))))))))))...)))))))(((((((.......)))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((.(((((((.((.....)))))))))......))))))))..)))(...(((......))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((((((.((.(.........((......((......(((.(.((....)).).)))...))................))).)).)))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(..(.........).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))). Structure of T. thermophilus 70S ribosome complex with mRNA and tRNALys in the A-site with wobble pair; 23S ribosomal RNA 5e81 16 122 2.95 RF00001 URS00005AB4A7_300852 26791911 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga ..<<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> ..(((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).))))))))))) Structure of T. thermophilus 70S ribosome complex with mRNA and tRNALys in the A-site with wobble pair; 5S ribosomal RNA 5e81 1G 1506 2.95 RF00177,RF01959,RF01960 URS00008FED22_300852 26791911 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucac .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<<..>>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<.......<<<<<<<..<<<<<<<....>>>>>>>....<<......>>...>>>>>>>..<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<...<<<.....>>>>......>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>....... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((())))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(.....((((((...((((((....)))))).....((......))...))))))..).((.(((...((((.(.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(....(((.....)))..)...))))))).....(((((....)))))........)))).....).)..))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}...... Structure of T. thermophilus 70S ribosome complex with mRNA and tRNALys in the A-site with wobble pair; 16S ribosomal RNA 5e81 1L 69 2.95 RF00005 URS000042DDAB_562 26791911 0030533 0006412 562 gggucguuagcucauggagcaguugacunuunaucaauugcgcaggnucgaauccugcacgacccacca <<..<<<..<<<<...>>>>.<<<<<.......>>>>>....<<<<.......>>>>.>>>..>>.... ((.......(((...[.)))..(((.........)))....(..((..]....))..).....)).... Structure of T. thermophilus 70S ribosome complex with mRNA and tRNALys in the A-site with wobble pair; tRNA-Lys 5e81 2L 77 2.95 RF00005 URS000057545F_300852 26791911 0030533 0006412 300852 cgcggggnggagcagcccgguagcucgucgggnucauaacccgaagnucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Structure of T. thermophilus 70S ribosome complex with mRNA and tRNALys in the A-site with wobble pair; tRNA-fMet 5e81 3L 72 2.95 RF00005 URS000042DDAB_300852 26791911 0030533 0006412 300852 gggucguuagcucaggagagcaguugacuuuuaaucaauuggucgcagguucgaauccugcacgacccacca .<<<<<<..<<<<....>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .(((.((..((((....))))((.(((.......))).))....(.(...........).))).)))..... Structure of T. thermophilus 70S ribosome complex with mRNA and tRNALys in the A-site with wobble pair; tRNA-Lys 5e81 4L 19 2.95 26791911 562 gagguaaaaaugaagaaaa ................... ................... Structure of T. thermophilus 70S ribosome complex with mRNA and tRNALys in the A-site with wobble pair; mRNA 5e81 14 2855 2.95 RF02540,RF02541,RF00002 URS0000868533_300852 26791911 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaacggcgaaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuaggaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcggacagccaggauguuggaagcagccaagagugcgagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccuguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucuugacc .........<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<....>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>..............>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...........>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<.......<<<<...............................>>>>.....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<..........<.....<<<.......<<<<<<<<..>>>>>>.>>...>>>..............>...>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<.............>>>>....>>>.>>>>.......>>>>>>>...<.........>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>............ .........((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((..)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((.(((((..).)))).)))....(.(((((((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))..............)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((...........)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((........(.....................................)......)))))))).))..........]]].)....))))))))))...)))))))((((((.(.....).))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((.(((.........((.....((.......(.((((((....)))).)))....))..............))..))).))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(..................(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)........ Structure of T. thermophilus 70S ribosome complex with mRNA and tRNALys in the A-site with wobble pair; 23S ribosomal RNA 5e81 1J 122 2.95 RF00001 URS00005AB4A7_300852 26791911 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga ..<<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> ..(((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).))))))))))) Structure of T. thermophilus 70S ribosome complex with mRNA and tRNALys in the A-site with wobble pair; 5S ribosomal RNA 5eao A 48 2.988 RF00008 URS0000868531_32630 26551631,26398724 3.1.-.- 0004540 32630 ggguacuuaagcccacugaugagucgcugggaugcgacgaaacgccca ......................<<<<<......>>>>>.......... ...............(....).(((((......))))).......... Two active site divalent ion in the crystal structure of the hammerhead ribozyme bound to a transition state analog-Mg2+; RNA (48-MER) 5eao B 20 2.988 URS00008FED4C_32630 26551631,26398724 32630 gggcgunugggcaguaccca .................... .................... Two active site divalent ion in the crystal structure of the hammerhead ribozyme bound to a transition state analog-Mg2+; RNA (5'-R(*GP*GP*GP*CP*GP*U*(CVC)*UP*GP*GP*GP*CP*AP*GP*UP*AP*CP*CP*CP*A)-3') 5eaq A 48 3.201 RF00008 URS0000868531_32630 26551631,26398724 3.1.-.- 0004540 32630 ggguacuuaagcccacugaugagucgcugggaugcgacgaaacgccca ......................<<<<<......>>>>>.......... ...............(....).(((((......))))).......... Two active site divalent ion in the crystal structure of the hammerhead ribozyme bound to a transition state analog-Mn2+; RNA (48-MER) 5eaq B 20 3.201 URS00008FED4C_32630 26551631,26398724 32630 gggcgunugggcaguaccca .................... .................... Two active site divalent ion in the crystal structure of the hammerhead ribozyme bound to a transition state analog-Mn2+; RNA (5'-R(*GP*GP*GP*CP*GP*U*(CVC)*UP*GP*GP*GP*CP*AP*GP*UP*AP*CP*CP*CP*A)-3') 5ed1 B 23 2.77 URS0000A76387_4932 27065196 4932 uuccccacauungacguucaguc ....................... ....................... Human Adenosine Deaminase Acting on dsRNA (ADAR2) mutant E488Q bound to dsRNA sequence derived from S. cerevisiae BDF2 gene; RNA (5'-R(*UP*UP*CP*CP*CP*CP*AP*CP*AP*UP*UP*(8AZ)P*GP*AP*CP*GP*UP*UP*CP*AP*GP*UP*C)-3') 5ed1 C 23 2.77 URS0000A763A5_4932 27065196 4932 gacugaacgaccaauguggggaa ....................... ....................... Human Adenosine Deaminase Acting on dsRNA (ADAR2) mutant E488Q bound to dsRNA sequence derived from S. cerevisiae BDF2 gene; RNA (5'-R(*GP*AP*CP*UP*GP*AP*AP*CP*GP*AP*CP*CP*AP*AP*UP*GP*UP*GP*GP*GP*GP*AP*A)-3') 5ed2 B 23 2.95 URS0000A7634A_9606 27065196 9606 gcucgcgaugcungagggcucug ....................... ....................... Human Adenosine Deaminase Acting on dsRNA (ADAR2) mutant E488Q bound to dsRNA sequence derived from human GLI1 gene; RNA (5'-R(P*GP*CP*UP*CP*GP*CP*GP*AP*UP*GP*CP*UP*(8AZ)P*GP*AP*GP*GP*GP*CP*UP*CP*UP*G)-3') 5ed2 C 23 2.95 URS0000A7638C_9606 27065196 9606 cagagccccccagcaucgcgagc ....................... ....................... Human Adenosine Deaminase Acting on dsRNA (ADAR2) mutant E488Q bound to dsRNA sequence derived from human GLI1 gene; RNA (5'-R(P*CP*AP*GP*AP*GP*CP*CP*CP*CP*CP*CP*AP*GP*CP*AP*UP*CP*GP*CP*GP*AP*GP*C)-3') 5ed2 E 23 2.95 URS0000A7634A_9606 27065196 9606 gcucgcgaugcungagggcucug ....................... ....................... Human Adenosine Deaminase Acting on dsRNA (ADAR2) mutant E488Q bound to dsRNA sequence derived from human GLI1 gene; RNA (5'-R(P*GP*CP*UP*CP*GP*CP*GP*AP*UP*GP*CP*UP*(8AZ)P*GP*AP*GP*GP*GP*CP*UP*CP*UP*G)-3') 5ed2 F 23 2.95 URS0000A7638C_9606 27065196 9606 cagagccccccagcaucgcgagc ....................... ....................... Human Adenosine Deaminase Acting on dsRNA (ADAR2) mutant E488Q bound to dsRNA sequence derived from human GLI1 gene; RNA (5'-R(P*CP*AP*GP*AP*GP*CP*CP*CP*CP*CP*CP*AP*GP*CP*AP*UP*CP*GP*CP*GP*AP*GP*C)-3') 5el4 13 1496 3.15 RF00177,RF01959,RF01960 URS0000868551_300852 26791911 0003735 0005840 300852 uuuuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggacacc .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<......>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<.........<<<.....>>>...........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<<....>>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<...<<<<....>>>>...>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>....... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(........).)))))......(((......((((((((..((...(((((((.(((((......(((......))).......)))))....((.(.(.(((....))).).).))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(......((.....)).......)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((((..(((((((....)))))))....(........)...))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((....(..(((.....)))).....)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}...... Structure of T. thermophilus 70S ribosome complex with mRNA and tRNALys in the A-site with a U-U mismatch in the first position; 16S ribosomal RNA 5el4 1K 69 3.15 RF00005 URS000042DDAB_83333 26791911 0030533 0006412 83333 gggucguuagcucaguggagcaguugacunuunaucaauucgcaggnucgaauccugcacgacccacca <<<<.....<<<<....>>>>.<<<<<.......>>>>>....<<<.......>>>.....>>>>.... ..(......(((......)))..(((.........))).....(((.......)))......)...... Structure of T. thermophilus 70S ribosome complex with mRNA and tRNALys in the A-site with a U-U mismatch in the first position; tRNA-Lys 5el4 2K 77 3.15 RF00005 URS000041AF00_83333 26791911 0030533 0006412 83333 cgcggggnggagcagccugguagcucgucgggnucauaacccgaagnucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Structure of T. thermophilus 70S ribosome complex with mRNA and tRNALys in the A-site with a U-U mismatch in the first position; tRNA-fMet 5el4 3K 76 3.15 RF00005 URS000042DDAB_83333 26791911 0030533 0006412 83333 gggucguuagcucaguugguagagcaguugacuuuuaaucaauuggucgcagguucgaauccugcacgacccacca <<<<.<<..<.<..........>.>.<<<<<.......>>>>>.......<<<.......>>>..>>.>>>>.... (((..(....(.(........).)..((((.........)))).......(.(........))...)..))).... Structure of T. thermophilus 70S ribosome complex with mRNA and tRNALys in the A-site with a U-U mismatch in the first position; tRNA-Lys 5el4 4K 20 3.15 26791911 562 ggagguaaaaauguaaaaaa .................... .................... Structure of T. thermophilus 70S ribosome complex with mRNA and tRNALys in the A-site with a U-U mismatch in the first position; mRNA 5el4 1H 2833 3.15 RF02540,RF02541,RF00002 URS0000868533_300852 26791911 0003735 0005840 300852 aagaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaacgggggccgaaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuaggggccuccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucuu .<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.....>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>..................>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<.<...........>.>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<..................>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>>....<<<......>>>......>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<.<<<<<<<<<...........<<<.<<..<<......<<<<<<<......>>>>>>>...>>.............>>>>>..>>>>>>>>>.>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<<..<<.......>>>..>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.....<.....>.......<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>. .(((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((((..(.....)..)))))....(.(((((((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))..................)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((.(..........)..)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((................)))))))))).))..........]]].)....))))))))))...)))))))(((((((.......)))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((......))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((.(((((..(.(.........((.(....((.........((...(...)..).).....))..............).))).)..))))).)))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))..(...........)....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))). Structure of T. thermophilus 70S ribosome complex with mRNA and tRNALys in the A-site with a U-U mismatch in the first position; 23S ribosomal RNA 5el4 16 122 3.15 RF00001 URS00005AB4A7_300852 26791911 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga ..<<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> ..(((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).))))))))))) Structure of T. thermophilus 70S ribosome complex with mRNA and tRNALys in the A-site with a U-U mismatch in the first position; 5S ribosomal RNA 5el4 1G 1507 3.15 RF00177,RF01959,RF01960 URS0000868551_300852 26791911 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucacc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<<..>>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<..[.>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>.......]..<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<.......<...<<<..<<<<<<<....>>>>>>>....<<......>>...>>.>..>...<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<...<<<.....>>>>......>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>....>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>........ .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((((((((....))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((.(....).)))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(.(((....)))..))))).)).))))))..((((.......(((....)))......))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((.(.((((((((((......((((((.....))))))....))))))))..))).)))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((.......))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..(((((((..(......((........))..........(((((((..(....(..(.((....(..((....))..)......((......))...)).)..).).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(....(((.....)))..)...))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))...)...))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((..........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((.....((((....(((....))).))))....)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}....... Structure of T. thermophilus 70S ribosome complex with mRNA and tRNALys in the A-site with a U-U mismatch in the first position; 16S ribosomal RNA 5el4 1L 74 3.15 RF00005 URS000042DDAB_83333 26791911 0030533 0006412 83333 gggucguuagcucaguuggugagcaguugacuuuuaaucaauugucgcaggnucgaauccugcacgacccacca .<.<<<<..<<<<.......>>>>....<<.......>>........<<<<.......>>>>.>>>>.>..... ...(((...((((....[..))))...((.........))..........(..]....).....)))....... Structure of T. thermophilus 70S ribosome complex with mRNA and tRNALys in the A-site with a U-U mismatch in the first position; tRNA-Lys 5el4 2L 76 3.15 RF00005 URS000041AF00_83333 26791911 0030533 0006412 83333 cgcggggnggagcagccuggagcucgucgggnucauaacccgaagnucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((........)))).(((((.......))))).....(((((.......)))))))))))..... Structure of T. thermophilus 70S ribosome complex with mRNA and tRNALys in the A-site with a U-U mismatch in the first position; tRNA-fMet 5el4 3L 74 3.15 RF00005 URS000042DDAB_83333 26791911 0030533 0006412 83333 gggucguuagcucaggguagagcaguugacuuuuaaucaauuggucgcagguucgaauccugcacgacccacca <<<<<<<..<<<<......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((......))))..(((.........)))......((((.........))))))))))).... Structure of T. thermophilus 70S ribosome complex with mRNA and tRNALys in the A-site with a U-U mismatch in the first position; tRNA-Lys 5el4 4L 17 3.15 26791911 562 ggagguaaaaauguaaa ................. ................. Structure of T. thermophilus 70S ribosome complex with mRNA and tRNALys in the A-site with a U-U mismatch in the first position; mRNA 5el4 14 2861 3.15 RF02540,RF02541,RF00002 URS0000868533_300852 26791911 0003735 0005840 300852 ggucaagaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaacggcgaaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuaggaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcggacagccaggauguuggaagcagccaagagugcgagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcuaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucuugacc ..<...........<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<....>>>>>.>>....<<<<<.....<......>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>..............>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...........>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<.........<<...............................>>.......>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>>....<<<<....>>>>......>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<.<<<<<<<..........<<..............<<<<<<<<<..>>>>>>>>>....................>>..>>>>>>>.>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<.............>>>>....>>>.>>>>.......>>>>>>>..<<<.......>>.>...<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>.........>.. ..............((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((..)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((((((((..).))))))))....(.(((((((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))..............)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((...........)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[.....((((((.....(.....((..(((((((.((...{..(.....................................)....)).))))))).))..........]]].)....)))))).)))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(....(((....)))......))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((.((.((.(((.(.........((....(.(......((((((((....))))))))....)).............)).).))).)).)).))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(...........)....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))...)........ Structure of T. thermophilus 70S ribosome complex with mRNA and tRNALys in the A-site with a U-U mismatch in the first position; 23S ribosomal RNA 5el4 1J 122 3.15 RF00001 URS00005AB4A7_300852 26791911 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga ...<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>. .....((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).))))))))... Structure of T. thermophilus 70S ribosome complex with mRNA and tRNALys in the A-site with a U-U mismatch in the first position; 5S ribosomal RNA 5el5 13 1493 3.15 RF00177,RF01959,RF01960 URS000080E226_300852 26791911 0003735 0005840 300852 uuuuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuagggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaca .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<...<<.<........>.>>.>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<...>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<..........<<.....>>............>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>.....<......>....>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(.(...(.(........).)..))......(((......((((((((..((...(((((((.(((((......((((....)))).......)))))....((((.(((((....))))).))))...(((.....))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((...))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(......((.....)).......)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((..(..(((((((....)))))))....(........)...)..)))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((.......(((.....)))......))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Structure of T. thermophilus 70S ribosome complex with mRNA and tRNALys in the A-site with a U-U mismatch in the second position; 16S ribosomal RNA 5el5 1K 69 3.15 RF00005 URS000042DDAB_83333 26791911 0030533 0006412 83333 gggucguuagcucaguggagcaguugacunuunaucaauucgcaggnucgaauccugcacgacccacca <<<<..................<<<<<.......>>>>>.....<<.......>>......>>>>.... .......................(((.........)))......((.......)).............. Structure of T. thermophilus 70S ribosome complex with mRNA and tRNALys in the A-site with a U-U mismatch in the second position; tRNALys 5el5 2K 77 3.15 RF00005 URS000057545F_83333 26791911 0030533 0006412 83333 cgcggggnggagcagcccgguagcucgucgggnucauaacccgaagnucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Structure of T. thermophilus 70S ribosome complex with mRNA and tRNALys in the A-site with a U-U mismatch in the second position; tRNAfMet 5el5 3K 76 3.15 RF00005 URS000042DDAB_83333 26791911 0030533 0006412 83333 gggucguuagcucaguugguagagcaguugacuuuuaaucaauuggucgcagguucgaauccugcacgacccacca .<<<<<...<<<<........>>>>.<<<<<.......>>>>>......<<<<.......>>>>..>>>>>..... .(((.....(((..........)))..((((.......)))).......((((.......))))....)))..... Structure of T. thermophilus 70S ribosome complex with mRNA and tRNALys in the A-site with a U-U mismatch in the second position; tRNALys 5el5 4K 20 3.15 26791911 83333 ggagguaaaaaugauaaaaa .................... .................... Structure of T. thermophilus 70S ribosome complex with mRNA and tRNALys in the A-site with a U-U mismatch in the second position; mRNA 5el5 1H 2830 3.15 RF02540,RF02541,RF00002 URS000080E23D_300852 26791911 0003735 0005840 300852 aagaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaacgggggccgaaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuaggggccuccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucuu .<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.....>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....<<.....>>....>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<....<......>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<..................>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>>....<<<<....>>>>......>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<.<<<<<<<<<...........<<<<............<<<<<<<<....>>>>>>>>................>>>>..>>>>>>>>>.>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<<<<<<<<<..<<.......>>>..>>>>>>>..>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<.........>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>. ..((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((((.((.....)).)))))....(.(((((((((......(...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)..)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))..................)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((.(..........)..)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((.(................).)))))))).))..........]]].)....))))))))))...)))))))(((((((.......)))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((.(((((((((.((.....))))))))).....)).))))))..)))(...(((......))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((.(.(.(((((.((...........((.(..............(.(.((....)).).)..................).))..)).))))).).).)))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.(...........)....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))...))).. Structure of T. thermophilus 70S ribosome complex with mRNA and tRNALys in the A-site with a U-U mismatch in the second position; 23S ribosomal RNA 5el5 16 122 3.15 RF00001 URS00005AB4A7_300852 26791911 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga ...<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>. ...((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).)))))))))). Structure of T. thermophilus 70S ribosome complex with mRNA and tRNALys in the A-site with a U-U mismatch in the second position; 5S ribosomal RNA 5el5 1G 1496 3.15 RF00177,RF01959,RF01960 URS000080E226_300852 26791911 0003735 0005840 300852 uuuuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccugggguggcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucacc .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<...<..<<<.<<<..<<<..<<.<<<<<<<<<<..>>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>...>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<.....>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<........<<........>>..........<<<<<<<...........<<<..<<<<<<<....>>>>>>>....>>>.......<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<...<<<.....>>>>......>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>....>>>>>>>......>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>........ .......(((...[.[[[...))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((..()..)))))))).)))))......(((......((((((((..((...(((((((.(((((....(((((......))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(.(((....)))..))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((.(......((((((.....))))))....).))))))..)))))))))...((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))...)))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((.....)))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((.(..((((((((((......((........))..........((..(((..(.......((........(........)..........))....)....(((.....((((......((((..(((....)))...(((......))).....)))).....((((.((((.((...(...(((.....)))).....)).)))).....(((((....)))))........)))).......).)))......)))......)))..))...)).)))))))).(...(((((((.....(((..(...((.(....).))...)....))).....)))))))......(....(((((((........)))))))....)..)..).))).....(((((((..........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}....... Structure of T. thermophilus 70S ribosome complex with mRNA and tRNALys in the A-site with a U-U mismatch in the second position; 16S ribosomal RNA 5el5 1L 74 3.15 RF00005 URS000042DDAB_83333 26791911 0030533 0006412 83333 gggucguuagcucaguuggugagcaguugacuuuuaaucaauugucgcaggnucgaauccugcacgacccacca <..<<<...<<<.........>>>..<<<<.......>>>>.......<<<.......>>>...>>>..>.... ....((....((.........))....((.........)).........((.......))....))........ Structure of T. thermophilus 70S ribosome complex with mRNA and tRNALys in the A-site with a U-U mismatch in the second position; tRNALys 5el5 2L 77 3.15 RF00005 URS000057545F_83333 26791911 0030533 0006412 83333 cgcggggnggagcagcccgguagcucgucgggnucauaacccgaagnucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Structure of T. thermophilus 70S ribosome complex with mRNA and tRNALys in the A-site with a U-U mismatch in the second position; tRNAfMet 5el5 3L 76 3.15 RF00005 URS000042DDAB_83333 26791911 0030533 0006412 83333 gggucguuagcucaguugguagagcaguugacuuuuaaucaauuggucgcagguucgaauccugcacgacccacca <<<<.....<<<..........>>>..<<<<.......>>>>......<<<<.........>>>>...>>>>.... (((......((............))...((.........)).......(((.(.......).)))....))).... Structure of T. thermophilus 70S ribosome complex with mRNA and tRNALys in the A-site with a U-U mismatch in the second position; tRNALys 5el5 4L 17 3.15 26791911 83333 ggagguaaaaaugauaa ................. ................. Structure of T. thermophilus 70S ribosome complex with mRNA and tRNALys in the A-site with a U-U mismatch in the second position; mRNA 5el5 14 2861 3.15 RF02540,RF02541,RF00002 URS000080E23D_300852 26791911 0003735 0005840 300852 ggucaagaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaacggcgaaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuaggaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcggacagccaggauguuggaagcagccaagagugcgagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcuaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucuugacc ..<...........<<<<<<<<<<<.....[[..[[<<<<<<[[<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<....>>>>>.>>....<<<<<.....<<....>>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...(((....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>.]]...............<<....>>....]].........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>..............>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...........>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<..........<...............................>........>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..((((...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.........<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<.<<<<<<<..........<<<<<...<<........<<<<<<....>>>>>>.....>>............>>>>>..>>>>>>>.>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<.(((..>>>>..)))>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))))>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<.............>>>>....>>>.>>>>.......>>>>>>>..<<<.......>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>.........>.. ..............((((((((((.....(((..((((((((((((......((((((.[[..[[[)))...].((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((......)))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((......(...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))...).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))..............)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...((((((((....(((...(((.((((...........)))).)))..)).)....))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[.....((((((.....(.....((..((((((((.....................................................)))))))).))..........]]].)....)))))).)))...)))))))(((((((.......)))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((.(((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...(((((((((((((((..((.....)).)))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))).))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((.((((((.(((...........(((...((.......(..(((........)).).)....))............)))...))).)))))).)))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....((((((..((..]]]]..)).)))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(..................(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))...)........ Structure of T. thermophilus 70S ribosome complex with mRNA and tRNALys in the A-site with a U-U mismatch in the second position; 23S ribosomal RNA 5el5 1J 122 3.15 RF00001 URS00005AB4A7_300852 26791911 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga ..<<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> ..((.((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).)))))))).)) Structure of T. thermophilus 70S ribosome complex with mRNA and tRNALys in the A-site with a U-U mismatch in the second position; 5S ribosomal RNA 5el6 13 1496 3.1 RF00177,RF01959,RF01960 URS000080E226_300852 26791911 0003735 0005840 300852 uuuuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggacacc .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<........>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>....<<......>>...>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>....... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(........).)))))......(((......((((((((..((...(((((((.(.(((......((........)).......))).)....((((.(.(((....))).).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(.....(((.....)))......)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((.(((...))).))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((((..(((((((....))))))).................))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(.(.....).)))....)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}...... Structure of T. thermophilus 70S ribosome complex with mRNA and tRNALys in the A-site with a U-U mismatch in the first position and antibiotic paromomycin; 16S rRNA 5el6 1K 69 3.1 RF00005 URS000042DDAB_83333 26791911 0030533 0006412 83333 gggucguuagcucaguggagcaguugacunuunaucaauucgcaggnucgaauccugcacgacccacca <<<<.<<...<<<....>>>..<<<<<.......>>>>>..<<<<<.......>>>>>>>.>>>>.... ((((..(.........[.....((((.........))))...(.((..]....)).).)..)))).... Structure of T. thermophilus 70S ribosome complex with mRNA and tRNALys in the A-site with a U-U mismatch in the first position and antibiotic paromomycin; tRNALys 5el6 2K 77 3.1 RF00005 URS000057545F_83333 26791911 0030533 0006412 83333 cgcggggnggagcagcccgguagcucgucgggnucauaacccgaagnucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Structure of T. thermophilus 70S ribosome complex with mRNA and tRNALys in the A-site with a U-U mismatch in the first position and antibiotic paromomycin; E. coli tRNAfMet 5el6 3K 76 3.1 RF00005 URS000042DDAB_83333 26791911 0030533 0006412 83333 gggucguuagcucaguugguagagcaguugacuuuuaaucaauuggucgcagguucgaauccugcacgacccacca <<<<.....<<<<........>>>>.<<<<<.......>>>>>.......<<<.......>>>.....>>>>.... ((((.....((((........))))..(((.........)))........(...........).....)))).... Structure of T. thermophilus 70S ribosome complex with mRNA and tRNALys in the A-site with a U-U mismatch in the first position and antibiotic paromomycin; tRNALys 5el6 4K 20 3.1 26791911 83333 ggagguaaaaauguaaaaaa .................... .................... Structure of T. thermophilus 70S ribosome complex with mRNA and tRNALys in the A-site with a U-U mismatch in the first position and antibiotic paromomycin; mRNA 5el6 1H 2833 3.1 RF02540,RF02541,RF00002 URS000080E23D_300852 26791911 0003735 0005840 300852 aagaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaacgggggccgaaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuaggggccuccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucuu <<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.....>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....<<.....>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<.<...>.>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<..................>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<.<<<<<<<<<...........<<......<<......<<<<<<<<....>>>>>>>>...>>................>>..>>>>>>>>>.>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<..<<<<<<<...<<.......>>...>>>>>>>...>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...................<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>> .(((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((.((((.....)))).)))....(.(((.(((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))..)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....((.....))....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((.(..(.....).)..)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((................)))))))))).))..........]]].)....))))))))))...)))))))(((((((.......)))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((.(((((((.((.....)))))))))......))))))))..)))(...(((......))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((.((((((..((.(.........((......((..........(((.(...)))).......))................))).))..)))))).)))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.(............)...(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))). Structure of T. thermophilus 70S ribosome complex with mRNA and tRNALys in the A-site with a U-U mismatch in the first position and antibiotic paromomycin; 23S rRNA 5el6 16 122 3.1 RF00001 URS00005AB4A7_300852 26791911 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga ..<<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> ..(((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).))))))))))) Structure of T. thermophilus 70S ribosome complex with mRNA and tRNALys in the A-site with a U-U mismatch in the first position and antibiotic paromomycin; 5S rRNA 5el6 1G 1507 3.1 RF00177,RF01959,RF01960 URS000080E226_300852 26791911 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucacc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<<..>>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>....<<<<.<<<<<....>>>>>.>>>>...<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<.<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>....<<......>>...>>>>>>>>..<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<...<<<.....>>>>......>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>....>>>>>>>...>..>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>........ .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((......)))))))).)))))......(((.......(((((((..((...(((((((.(((((....((((.(....).)))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.(.((((((((......((((((.....))))))....))))))))...))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((.(((((((...))))))).))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(.....((.(((...(.(((......))).).....((......))...))).))..).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.((((((...(....(((.....)))..)....)))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((..........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}....... Structure of T. thermophilus 70S ribosome complex with mRNA and tRNALys in the A-site with a U-U mismatch in the first position and antibiotic paromomycin; 16S rRNA 5el6 1L 73 3.1 RF00005 URS000042DDAB_83333 26791911 0030533 0006412 83333 gggucguuagcucaguuggugagcaguugacunuunaucaauugcgcaggnucgaauccugcacgacccacca <<<<<<<..<<<<...<...>>>>.<.<<<.......>>>.>....<<<<...>...>>>>.>>>>>>>.... ((...(....(((....[..)))..(.((.........)).)...((.((..]....)).)).)...)).... Structure of T. thermophilus 70S ribosome complex with mRNA and tRNALys in the A-site with a U-U mismatch in the first position and antibiotic paromomycin; tRNALys 5el6 2L 77 3.1 RF00005 URS000057545F_83333 26791911 0030533 0006412 83333 cgcggggnggagcagcccgguagcucgucgggnucauaacccgaagnucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Structure of T. thermophilus 70S ribosome complex with mRNA and tRNALys in the A-site with a U-U mismatch in the first position and antibiotic paromomycin; E. coli tRNAfMet 5el6 3L 76 3.1 RF00005 URS000042DDAB_83333 26791911 0030533 0006412 83333 gggucguuagcucaguugguagagcaguugacuuuuaaucaauuggucgcagguucgaauccugcacgacccacca .<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((..((..(.((........)).)..(((.........)))......(..((.......))..)))..))..... Structure of T. thermophilus 70S ribosome complex with mRNA and tRNALys in the A-site with a U-U mismatch in the first position and antibiotic paromomycin; tRNALys 5el6 4L 18 3.1 26791911 83333 ggagguaaaaauguaaaa .................. .................. Structure of T. thermophilus 70S ribosome complex with mRNA and tRNALys in the A-site with a U-U mismatch in the first position and antibiotic paromomycin; mRNA 5el6 14 2861 3.1 RF02540,RF02541,RF00002 URS000080E23D_300852 26791911 0003735 0005840 300852 ggucaagaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaacggcgaaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuaggaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcggacagccaggauguuggaagcagccaagagugcgagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcuaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucuugacc .<..<.........<<<<<<<<<<<.....[[..[[<<<<<<[[<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<....>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...(((....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>.]]...............<<....>>....]].........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>..............>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...........>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<.....<...<<...............................>>..>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..((((...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.........<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<.....<<<......<<<<<<<<<..>>>>>>>>>...>>>..............>...>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<.(((..>>>>..)))>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))))>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<.............>>>>....>>>.>>>>.......>>>>>>>...<<.......>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>.......>..>. ..............((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((......)))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))..............)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((...........)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((((((...................................................))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((.((((.(((.(.........((....(((......(((.((((....)))).)))...))).............)).).))).)))).)))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(..((.......)).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)........ Structure of T. thermophilus 70S ribosome complex with mRNA and tRNALys in the A-site with a U-U mismatch in the first position and antibiotic paromomycin; 23S rRNA 5el6 1J 122 3.1 RF00001 URS00005AB4A7_300852 26791911 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga ..<<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> ..(((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).))))))))))) Structure of T. thermophilus 70S ribosome complex with mRNA and tRNALys in the A-site with a U-U mismatch in the first position and antibiotic paromomycin; 5S rRNA 5el7 13 1496 3.15 RF00177,RF01959,RF01960 URS0000868551_300852 26791911 0003735 0005840 300852 uuuuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggacacc .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<......>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>.................>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>....... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(........).)))))......(((......((((((((..((...(((((((.(((((......((........)).......)))))....((((.(.(((....))).).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(.....(((.....)))......)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((((..(((((((....))))))).................))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((.......(((.....)))......)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}...... Structure of T. thermophilus 70S ribosome complex with mRNA and tRNALys in the A-site with a U-U mismatch in the second position and antibiotic paromomycin; 16S rRNA 5el7 1K 69 3.15 RF00005 URS000042DDAB_83333 26791911 0030533 0006412 83333 gggucguuagcucaguggagcaguugacunuunaucaauucgcaggnucgaauccugcacgacccacca <<<<<....<<<......>>>.<<<<<.......>>>>>....<<<.......>>>....>>>>>.... (.((.....((........))..(((.........)))......((.......))......)).).... Structure of T. thermophilus 70S ribosome complex with mRNA and tRNALys in the A-site with a U-U mismatch in the second position and antibiotic paromomycin; tRNALys 5el7 2K 77 3.15 RF00005 URS000057545F_83333 26791911 0030533 0006412 83333 cgcggggnggagcagcccgguagcucgucgggnucauaacccgaagnucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Structure of T. thermophilus 70S ribosome complex with mRNA and tRNALys in the A-site with a U-U mismatch in the second position and antibiotic paromomycin; E. coli tRNAfMet 5el7 3K 76 3.15 RF00005 URS000042DDAB_83333 26791911 0030533 0006412 83333 gggucguuagcucaguugguagagcaguugacuuuuaaucaauuggucgcagguucgaauccugcacgacccacca ..<<......<<..........>>..<<<<<.......>>>>>.......<<<.......>>>.....>>...... ...(.....((((........)))).((((.........)))).......((.........))....)........ Structure of T. thermophilus 70S ribosome complex with mRNA and tRNALys in the A-site with a U-U mismatch in the second position and antibiotic paromomycin; tRNALys 5el7 4K 20 3.15 26791911 562 ggagguaaaaaugauaaaaa .................... .................... Structure of T. thermophilus 70S ribosome complex with mRNA and tRNALys in the A-site with a U-U mismatch in the second position and antibiotic paromomycin; mRNA 5el7 1H 2833 3.15 RF02540,RF02541,RF00002 URS0000868533_300852 26791911 0003735 0005840 300852 aagaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaacgggggccgaaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuaggggccuccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucuu <<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.....>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....<<.....>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<.<.<<.....>>>..>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<..................>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>.>..>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<...<..<<......<<<<<<<<....>>>>>>>>...>>.............>..>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<<<<<<<<<..<<.......>>>..>>>>>>>..>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...................<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>> .(((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((......(...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)..)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....((.....))....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((.(.(.......))..)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((.(................).)))))))).))..........]]].)....))))))))))...)))))))(((((((.......)))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((......))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((.(.(((((((.((...........((..(....(......(((.((((....)))).)))....)..............).))..)).))))))).).)))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.((.((.........)).))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.(...........)....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))). Structure of T. thermophilus 70S ribosome complex with mRNA and tRNALys in the A-site with a U-U mismatch in the second position and antibiotic paromomycin; 23S rRNA 5el7 16 122 3.15 RF00001 URS00005AB4A7_300852 26791911 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga ..<<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> ..(((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).))))))))))) Structure of T. thermophilus 70S ribosome complex with mRNA and tRNALys in the A-site with a U-U mismatch in the second position and antibiotic paromomycin; 5S rRNA 5el7 1G 1506 3.15 RF00177,RF01959,RF01960 URS0000868551_300852 26791911 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucacc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<<..>>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>.........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<.......<<<<<<...<<<<<<<....>>>>>>>..................>>>>>>..<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>........ .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((((((((.().))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((.......(((....)))......))))....(((((...(....((((.....)))).....)...)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(.....((((((...(..(((....)))..)......(......)....))))))..)..(.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(....(((.....)))..)...))))))).....(((((....)))))........)))).....).).)))...)).)))).....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}....... Structure of T. thermophilus 70S ribosome complex with mRNA and tRNALys in the A-site with a U-U mismatch in the second position and antibiotic paromomycin; 16S rRNA 5el7 1L 73 3.15 RF00005 URS000042DDAB_83333 26791911 0030533 0006412 83333 gggucguuagcucaguuggugagcaguugacunuunaucaauugcgcaggnucgaauccugcacgacccacca <<.<<<<..<<<.........>>>.<<<<<.......>>>>>.....<<<.......>>>..>>>>.>>.... ((..(.(...(.(.......).)..((((.........))).)....(((.......)))..).)..)).... Structure of T. thermophilus 70S ribosome complex with mRNA and tRNALys in the A-site with a U-U mismatch in the second position and antibiotic paromomycin; tRNALys 5el7 2L 77 3.15 RF00005 URS000057545F_83333 26791911 0030533 0006412 83333 cgcggggnggagcagcccgguagcucgucgggnucauaacccgaagnucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Structure of T. thermophilus 70S ribosome complex with mRNA and tRNALys in the A-site with a U-U mismatch in the second position and antibiotic paromomycin; E. coli tRNAfMet 5el7 3L 75 3.15 RF00005 URS000042DDAB_83333 26791911 0030533 0006412 83333 gggucguuagccaguugguagagcaguugacuuuunaucaauuggucgcagguucgaauccugcacgacccacca .<<<.....................<<<<<.......>>>>>.....<<<<.........>>>>...>>>..... .........(.............)..(((.........)))........(...........)............. Structure of T. thermophilus 70S ribosome complex with mRNA and tRNALys in the A-site with a U-U mismatch in the second position and antibiotic paromomycin; tRNALys 5el7 4L 19 3.15 26791911 562 ggagguaaaaaugauaaaa ................... ................... Structure of T. thermophilus 70S ribosome complex with mRNA and tRNALys in the A-site with a U-U mismatch in the second position and antibiotic paromomycin; mRNA 5el7 14 2861 3.15 RF02540,RF02541,RF00002 URS0000868533_300852 26791911 0003735 0005840 300852 ggucaagaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaacggcgaaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuaggaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcggacagccaggauguuggaagcagccaagagugcgagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcuaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucuugacc .<<...<.......<<<<<<<<<<<.....[[..[[<<<<<<[[<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<..>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...(((....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>.]]...............<<....>>....]].........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>..............>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...........>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<......<<.<<...............................>>.>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..((((...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.........<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<..........<<.....<<<.......<<<<<<<<..>>>>>>>.>...>>>..............>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<.(((..>>>>..)))>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))))>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<.............>>>>....>>>.>>>>.......>>>>>>>...<<.......>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>.....>...>>. ..............((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((......)))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((((((((..).))))))))....(.(((((((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))..............)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((...........)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((.(...{..(.....................................)....).)))))))).))..........]]].)....))))))))))...)))))))((((((.........))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((.(.((.....))).))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((.(((.((((((.(........((.....((.......(.(.((((....))))..))....))..............))).)))))).))).)))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(..................(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)........ Structure of T. thermophilus 70S ribosome complex with mRNA and tRNALys in the A-site with a U-U mismatch in the second position and antibiotic paromomycin; 23S rRNA 5el7 1J 122 3.15 RF00001 URS00005AB4A7_300852 26791911 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga ..<<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> ..(((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).))))))))))) Structure of T. thermophilus 70S ribosome complex with mRNA and tRNALys in the A-site with a U-U mismatch in the second position and antibiotic paromomycin; 5S rRNA 5ew4 A 20 1.47 URS00008FED27_9606 26878348 9606 cccggccccggccccggccc .................... .................... Crystal structure of C9ORF72 Antisense CCCCGG repeat RNA associated with Lou Gehrig's disease and frontotemporal dementia, crystallized with Sr2+; RNA (5'-R(*CP*CP*CP*CP*GP*GP*CP*CP*CP*CP*GP*GP*CP*CP*CP*CP*GP*GP*CP*CP*CP*C)-3') 5ew4 B 21 1.47 URS00008FED27_9606 26878348 9606 ccccggccccggccccggccc ..................... ..................... Crystal structure of C9ORF72 Antisense CCCCGG repeat RNA associated with Lou Gehrig's disease and frontotemporal dementia, crystallized with Sr2+; RNA (5'-R(*CP*CP*CP*CP*GP*GP*CP*CP*CP*CP*GP*GP*CP*CP*CP*CP*GP*GP*CP*CP*CP*C)-3') 5ew7 A 20 1.75 URS00008FED27_9606 26878348 9606 cccggccccggccccggccc .................... .................... Crystal structure of C9ORF72 Antisense CCCCGG repeat RNA associated with Lou Gehrig's disease and frontotemporal dementia, crystallized with Ba2+; RNA (5'-R(*CP*CP*CP*CP*GP*GP*CP*CP*CP*CP*GP*GP*CP*CP*CP*CP*GP*GP*CP*CP*CP*C)-3') 5ew7 B 21 1.75 URS00008FED27_9606 26878348 9606 ccccggccccggccccggccc ..................... ..................... Crystal structure of C9ORF72 Antisense CCCCGG repeat RNA associated with Lou Gehrig's disease and frontotemporal dementia, crystallized with Ba2+; RNA (5'-R(*CP*CP*CP*CP*GP*GP*CP*CP*CP*CP*GP*GP*CP*CP*CP*CP*GP*GP*CP*CP*CP*C)-3') 5f8g B 12 2.78 URS000080DEB1_32630 27339134 32630 ggucucucucgu ............ ............ Enterovirus 71 Polymerase Elongation Complex (C1S1 Form); RNA (35-MER) 5f8g C 10 2.78 URS000080DFB4_32630 27339134 32630 acgagagaga .......... .......... Enterovirus 71 Polymerase Elongation Complex (C1S1 Form); RNA (5'-R(*UP*GP*UP*UP*CP*GP*AP*CP*GP*AP*GP*AP*GP*AP*GP*A)-3') 5f8h B 12 2.45 URS000080DEB1_32630 27339134 32630 ggucucucucgu ............ ............ Enterovirus 71 Polymerase Elongation Complex (C1S1/2 Form); RNA (35-MER) 5f8h C 10 2.45 URS000080DFB4_32630 27339134 32630 acgagagaga .......... .......... Enterovirus 71 Polymerase Elongation Complex (C1S1/2 Form); RNA (5'-R(*UP*GP*UP*UP*CP*GP*AP*CP*GP*AP*GP*AP*GP*AP*GP*A)-3') 5f8i B 12 2.503 URS000080DEB1_32630 27339134 32630 ggucucucucgu ............ ............ Enterovirus 71 Polymerase Elongation Complex (C1S2/3 Form); RNA (35-MER) 5f8i C 10 2.503 URS000080DFB4_32630 27339134 32630 acgagagaga .......... .......... Enterovirus 71 Polymerase Elongation Complex (C1S2/3 Form); RNA (5'-R(*UP*GP*UP*UP*CP*GP*AP*CP*GP*AP*GP*AP*GP*AP*GP*A)-3') 5f8j B 12 2.675 URS000080DEB1_32630 27339134 32630 ggucucucucgu ............ ............ Enterovirus 71 Polymerase Elongation Complex (C1S4 Form); RNA (35-MER) 5f8j C 11 2.675 URS000080DFD6_32630 27339134 32630 acgagagagac ........... ........... Enterovirus 71 Polymerase Elongation Complex (C1S4 Form); RNA (5'-R(*UP*GP*UP*UP*CP*GP*AP*CP*GP*AP*GP*AP*GP*AP*GP*AP*C)-3') 5f8k 1A 2872 2.8 RF02540,RF02541,RF00002 URS00001698E8_300852 26792896 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>....<<<<<.....<......>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<....<<<.......>>>....>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<.<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>.>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((...((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...((((((((.(.((((((......)))).)))..))))))))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((.((((((.(.........(((((..(((......((((((((....))))))))...)))............)))))).)))))).)))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((.))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal structure of the Bac7(1-16) antimicrobial peptide bound to the Thermus thermophilus 70S ribosome; 23S ribosomal RNA 5f8k 1B 120 2.8 RF00001 URS000080DFF2_300852 26792896 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the Bac7(1-16) antimicrobial peptide bound to the Thermus thermophilus 70S ribosome; 5S ribosomal RNA 5f8k 1a 1500 2.8 RF00177,RF01959,RF01960 URS000080E378_300852 26792896 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>.....<......>....>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((..)))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((((((....))))))).(.((((....)))))..)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the Bac7(1-16) antimicrobial peptide bound to the Thermus thermophilus 70S ribosome; 16S ribosomal RNA 5f8k 1x 76 2.8 RF00005 URS00002905B5_83333 26792896 0030533 0006412 83333 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the Bac7(1-16) antimicrobial peptide bound to the Thermus thermophilus 70S ribosome; tRNAiMet 5f8k 2A 2867 2.8 RF02540,RF02541,RF00002 URS00001698E8_300852 26792896 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu 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(((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((..))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...((((((((.(.((((((......)))).)))..))))))))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......(((((.((...(((.......)))....)).....(...(........).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))(((((((())))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((..((((.(......[..((((...(((.......(.((.((....)).))).....)))..........]..))))).)))).).)))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))((((.))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal structure of the Bac7(1-16) antimicrobial peptide bound to the Thermus thermophilus 70S ribosome; 23S ribosomal RNA 5f8k 2B 120 2.8 RF00001 URS000080DFF2_300852 26792896 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> .((((((((((....((((((((....(.(((((...(.....)...))))..).)...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the Bac7(1-16) antimicrobial peptide bound to the Thermus thermophilus 70S ribosome; 5S ribosomal RNA 5f8k 2a 1504 2.8 RF00177,RF01959,RF01960 URS000080E378_300852 26792896 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>.................>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((.(..).)))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...((((((......)))))).(...(......)...).)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the Bac7(1-16) antimicrobial peptide bound to the Thermus thermophilus 70S ribosome; 16S ribosomal RNA 5f8k 2x 76 2.8 RF00005 URS00002905B5_83333 26792896 0030533 0006412 83333 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the Bac7(1-16) antimicrobial peptide bound to the Thermus thermophilus 70S ribosome; tRNAiMet 5f8l B 12 2.812 URS000080DEB1_32630 27339134 32630 caggucucucuc ............ ............ Enterovirus 71 Polymerase Elongation Complex (C3S1 Form); RNA (35-MER) 5f8l C 10 2.812 URS000080E24A_32630 27339134 32630 gagagagacc .......... .......... Enterovirus 71 Polymerase Elongation Complex (C3S1 Form); RNA (5'-R(*UP*GP*UP*UP*CP*GP*AP*CP*GP*AP*GP*AP*GP*AP*GP*AP*CP*C)-3') 5f8m B 12 2.83 URS000080DEB1_32630 27339134 32630 caggucucucuc ............ ............ Enterovirus 71 Polymerase Elongation Complex (C3S4/5 Form); RNA (35-MER) 5f8m C 10 2.83 URS0000A76381_32630 27339134 32630 agagagaccu .......... .......... Enterovirus 71 Polymerase Elongation Complex (C3S4/5 Form); RNA (5'-R(*UP*GP*UP*UP*CP*GP*AP*CP*GP*AP*GP*AP*GP*AP*GP*AP*CP*CP*U)-3') 5fci 2 1781 3.4 RF01960,RF01959,RF00177 URS00005F2C2D_559292 26906928 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucau ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[..................<.....<<.<<<.....>>>.>>......>.........<<<<<..<......>..>>>>>....((((((......<<<<<<<<<<......>>..............)))))).........<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<.<<.<..........>.>>.>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.[[....<<<<<<.<<<<<....<..>....>>>>>.>>>>>>....<<<<<<...........<.......>...........>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[...((((((((....>>>>>>>>.))))))))..]].....]]....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<......>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<.......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>>....>.>>>>>....>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>......<....<<<<<<..........>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<.<<...<.........>....>>.>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>....... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[.[[[[[(((....))).....(......).)))))).)...).(.((((..((.......)).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....((..(.((..............)).)...))......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((.....(((((.(((((.....().....))))).)))))......(((((...............................)))))....(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(....(.((.(((....]]]]].]].))).)).)...).....))...(((..((..(...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)..))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.((..........))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...((.(((..((..................))..))).))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>...... Structure of the vacant uL3 W255C mutant 80S yeast ribosome; 18S ribosomal RNA 5fci 1 3149 3.4 RF02540,RF02543 URS000061F377_559292 26906928 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<<.<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<......<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<<..>>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<...<<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>>.<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>(><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<<..<<<<<<.....>>>>>>>>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>).<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<......<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>....>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><..<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>...>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>>....<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>.....<<<<<<<<....>>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<...............>>>>><<.<<<<<<<<<<......>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<...<<.....<<<<....>>>>.....>>.>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<.....>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<<...<<<<<<<<<<}}}.>>>>>..>>>>>..>>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<........>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((......((((.(....).)))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...((.(((.....))).)).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((.(.....((.........)).....).....(...(........).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))..........(...(.....)....)......))....))...(((((........)))))]]((((..(((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((((.(...)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.........)))))))....((((.....((((..((((........))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..).....(((((((((.(((....((((.(..(.(.((..)..).).)..)))))...)))....)))).)))))..))))).. Structure of the vacant uL3 W255C mutant 80S yeast ribosome; 25S ribosomal RNA 5fci 3 121 3.4 RF00001 URS000055688D_559292 26906928 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Structure of the vacant uL3 W255C mutant 80S yeast ribosome; 5S ribosomal RNA 5fci 4 158 3.4 RF00002 URS00001BF64E_559292 26906928 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((...(.]].)..........).)))..)...)))....((.....))(((((((((....)))))))))..................... Structure of the vacant uL3 W255C mutant 80S yeast ribosome; 5.8S ribosomal RNA 5fci 6 1795 3.4 RF01960,RF01959,RF00177 URS00005F2C2D_559292 26906928 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccucuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccgguccgauuuuuucguacuggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[...............<.....<<.<<.......>>.>>......>.........<<<<<..<<....>>..>>>>>[...((((((......<<<<<<<<<<<<..>>>>....<<......>>)))))).....]...<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<<<<...<......>...>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.{{....<<<<<<.<<...<<<<...............>>>>.......>>.>>>>>>....<<<<<<....<<..<<<<.......>>>>..>>....>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[[..((((((((....>>>>>>>>.)))))))).]]].....}}....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<<<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>...>.>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<.<<<..<........>....>>>.>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((...............(.....((.(((.....))).))......).........(((((..((....))..)))))(.(.((((((......[[[[[[[...(....).......(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(.(((.(................).)).).)......(.(.(...........))..).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((..((((...............))))......))).))))))....((((((....((..(((((.....)))))..))....))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(((..(.((((((.....]]]]]]].)))))).).))).....))...(((..((..(...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)..))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((........((.(((........))).))......)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...(((((((........................)))))))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>........ Structure of the vacant uL3 W255C mutant 80S yeast ribosome; 18S ribosomal RNA 5fci 7 121 3.4 RF00001 URS000055688D_559292 26906928 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<<............>>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((.(((...(....)...)))....))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Structure of the vacant uL3 W255C mutant 80S yeast ribosome; 5S ribosomal RNA 5fci 8 158 3.4 RF00002 URS00001BF64E_559292 26906928 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Structure of the vacant uL3 W255C mutant 80S yeast ribosome; 5.8S ribosomal RNA 5fcj 2 1781 3.1 RF01960,RF01959,RF00177 URS00005F2C2D_559292 26906928 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucau ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[..................<.....<<.<<.......>>.>>......>.........<<<<<..<......>..>>>>>[...((((((......<<<<<<<<<<......>>..............)))))).....]...<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<..<.<..........>.>..>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.[[....<<<<<<.<<<<<....<..>....>>>>>.>>>>>>....<<<<<<...............................>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[...((((((((....>>>>>>>>.))))))))..]].....]]....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>.>.>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>>....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<.<<...<.........>....>>.>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>....... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((..(......)..)))))(.(.((((((......[[[[[[[[(((....))).....(......).)))))).)...).(.((((..((.......)).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....((..(.(((............))).)...))......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((((.....().....))))).))))))....((((((...............................))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(....(.((.(((....]]]]]]]].))).)).)...).....))...(((..((.((...((((..((..((((((.(...((........))......).))))))..)).......((....))...))))..)).))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...((.((...((..................))...)).))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>...... Structure of the anisomycin-containing uL3 W255C mutant 80S yeast ribosome; 18S ribosomal RNA 5fcj 1 3149 3.1 RF02540,RF02543 URS000061F377_559292 26906928 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>...{.....<<....>>..<<<<<......<<.....>>.....>>>>>..[[[...<.......<<.<<<<<<...>>>>>>.>>.......>.....<<<<<<.<<<<<<<<<<<<<<<<<<<<<.....<<<<......>>>>.(.......<<<......)>>>....>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]....}.............................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<......<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<...<<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<....<....>....>>>.>>>.>>....>>>>>>.>>>>>>>.<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>>..<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<......>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<...<<.....<<<<....>>>>.....>>.>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<.....>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<........>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((......((((........)))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...((((((.....)))))).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((.(((...((.........))...))).....(...(........).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........(.....(.....)......)....))....))...(((((........)))))]]((((..(((.(((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....)))...))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((((.(...)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.........)))))))....((((.....((((..(((..........)))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(.((((..)..))).)..)))))...)))....)))).)))))).))))).. Structure of the anisomycin-containing uL3 W255C mutant 80S yeast ribosome; 25S ribosomal RNA 5fcj 3 121 3.1 RF00001 URS000055688D_559292 26906928 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Structure of the anisomycin-containing uL3 W255C mutant 80S yeast ribosome; 5S ribosomal RNA 5fcj 4 158 3.1 RF00002 URS00001BF64E_559292 26906928 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Structure of the anisomycin-containing uL3 W255C mutant 80S yeast ribosome; 5.8S ribosomal RNA 5fcj 6 1795 3.1 RF01960,RF01959,RF00177 URS00005F2C2D_559292 26906928 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccucuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccgguccgauuuuuucguacuggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[...............<.....<<.<<.......>>.>>......>.........<<<<<..<<....>>..>>>>>[...((((((......<<<<<<<<<<<<..>>>>....<........>)))))).....]...<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<<<<...<......>...>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.{{....<<<<<<.<<<..<<<<...............>>>>......>>>.>>>>>>....<<<<<<....<<..<<<<.......>>>>..>>....>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[[..((((((((....>>>>>>>>.)))))))).]]].....}}....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<<.....>.>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<......>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<.......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>.....>.>>>>>....>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<.<<<..<........>....>>>.>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((...............(.....((.(((.....))).))......).........(((((..((....))..)))))(.(.((((((......[[[[[[[...(....).......(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(((((.(................).)).)))......(.(.(...........))..).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((..((((...............))))......))).))))))....((((((....((..(((((.....)))))..))....))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(((..(.((((((.....]]]]]]].)))))).).))).....))...(((..((..(...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)..))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((........((.(((........))).))......)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...(((((((.((..................)).)))))))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>........ Structure of the anisomycin-containing uL3 W255C mutant 80S yeast ribosome; 18S ribosomal RNA 5fcj 5 3150 3.1 RF02540,RF02543 URS000061F377_559292 26906928 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacauggcugggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<<....>>......>>>>>.>...{.....<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<.<<<<<..<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>......>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]....}.............................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<<...........<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<...<<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>>.<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<<..<<<<<<.....>>>>>>>>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<<.....>.>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<...............>>>>><<.<<<<<<<<<<<..>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<..<<<.....<<<<....>>>>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<.<.....>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<......>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<.}}}..>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..)))))).))...)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((...........(((((((((((((((((((((((.......(((((((......((((((....)))))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...(.((((.....)))).).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.......(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((..((((((....((.....))..)))))....[[(((.((...((....(((....)))........(.(..(.(...)..)..).)....))....))...(((((........)))))]]((((.((((((.(...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....).))..)))))))).))).))).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((..)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...(......((((....))))......).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(.((............)).)....((((.....((((..((((........))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).).......(((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).))....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.............))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Structure of the anisomycin-containing uL3 W255C mutant 80S yeast ribosome; 25S ribosomal RNA 5fcj 7 121 3.1 RF00001 URS000055688D_559292 26906928 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Structure of the anisomycin-containing uL3 W255C mutant 80S yeast ribosome; 5S ribosomal RNA 5fcj 8 158 3.1 RF00002 URS00001BF64E_559292 26906928 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Structure of the anisomycin-containing uL3 W255C mutant 80S yeast ribosome; 5.8S ribosomal RNA 5fdu 1A 2872 2.9 RF02540,RF02541,RF00002 URS00001698E8_300852 26792896 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<.....<<.......>>.....>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<<..>>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((..(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...((((((((.(.((((((......)))).)))..))))))))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((...................))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(......[..(((((..(((......((((((.(....).))))))...)))..........].)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..((((.))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the Metalnikowin I antimicrobial peptide bound to the Thermus thermophilus 70S ribosome; 23S ribosomal RNA 5fdu 1B 120 2.9 RF00001 URS000080DFF2_300852 26792896 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the Metalnikowin I antimicrobial peptide bound to the Thermus thermophilus 70S ribosome; 5S ribosomal RNA 5fdu 1a 1500 2.9 RF00177,RF01959,RF01960 URS000080DFED_300852 26792896 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>.<.<<<......>>>>.>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((..)))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((...(((((((....)))))))...(((......)))...)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the Metalnikowin I antimicrobial peptide bound to the Thermus thermophilus 70S ribosome; 16S ribosomal RNA 5fdu 2A 2867 2.9 RF02540,RF02541,RF00002 URS00001698E8_300852 26792896 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..................>>>......................>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<..<<<......<.<<<<<<....>>>>>>>....>>>............>>>>>..>>>>.>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((..))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...((((((((.(.((((((......)))).)))..))))))))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......(((((.((....................)).....(...(........).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))(((((((())))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((..((((.(.........(((((..(((.......(.((.((....)).))).....)))............)))))).)))).).)))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))((((.))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal structure of the Metalnikowin I antimicrobial peptide bound to the Thermus thermophilus 70S ribosome; 23S ribosomal RNA 5fdu 2B 120 2.9 RF00001 URS000080DFF2_300852 26792896 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>. .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the Metalnikowin I antimicrobial peptide bound to the Thermus thermophilus 70S ribosome; 5S ribosomal RNA 5fdu 2a 1504 2.9 RF00177,RF01959,RF01960 URS000080DFED_300852 26792896 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<..[.>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>.......]..<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<.<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>.....<......>....>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>..>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((((((....))))))).(...((....))...).)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the Metalnikowin I antimicrobial peptide bound to the Thermus thermophilus 70S ribosome; 16S ribosomal RNA 5fdv 1A 2872 2.8 RF02540,RF02541,RF00002 URS00001698E8_300852 26792896 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<...<<<.......>>>...>>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<<..>>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((..(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...((((((((.(.((((((......)))).)))..))))))))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((...................))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(......[..(((((..((.......((((((.(....).))))))....))..........].)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..((((.))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the Pyrrhocoricin antimicrobial peptide bound to the Thermus thermophilus 70S ribosome; 23S ribosomal RNA 5fdv 1B 120 2.8 RF00001 URS000080DFF2_300852 26792896 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the Pyrrhocoricin antimicrobial peptide bound to the Thermus thermophilus 70S ribosome; 5S ribosomal RNA 5fdv 1a 1500 2.8 RF00177,RF01959,RF01960 URS000080DFED_300852 26792896 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<......>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>.........<.<<<<<<<........>>>>>>>>.........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((..)))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((..((((....))))..))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((...(((((((....)))))))...(((......)))...)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the Pyrrhocoricin antimicrobial peptide bound to the Thermus thermophilus 70S ribosome; 16S ribosomal RNA 5fdv 2A 2867 2.8 RF02540,RF02541,RF00002 URS00001698E8_300852 26792896 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..................>>>......................>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<..<<<......<.<<<<<<....>>>>>>>....>>>............>>>>>..>>>>.>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((..))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...((((((((.(.((((((......)))).)))..))))))))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((........((((.((...(((.......)))....)).....(...(........).).))))....)))))))))).))..........]]].)....))))))))))...)))))))(((((((())))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((..((((.(......[..(((((..(((.......(.((.((....)).))).....)))..........].)))))).)))).).)))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))((((.))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal structure of the Pyrrhocoricin antimicrobial peptide bound to the Thermus thermophilus 70S ribosome; 23S ribosomal RNA 5fdv 2B 120 2.8 RF00001 URS000080DFF2_300852 26792896 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>>. .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the Pyrrhocoricin antimicrobial peptide bound to the Thermus thermophilus 70S ribosome; 5S ribosomal RNA 5fdv 2a 1504 2.8 RF00177,RF01959,RF01960 URS000080DFED_300852 26792896 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<.<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>.....<......>....>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>..>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((((((....))))))).(...((....))...).)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the Pyrrhocoricin antimicrobial peptide bound to the Thermus thermophilus 70S ribosome; 16S ribosomal RNA 5fj0 A 19 2.2 URS000080E16F_2238 27016741 2238 ggcgaagaaccggggagcc ................... ................... Structure of the standard kink turn HmKt-7 as simple duplex in P4222 space group; HMKT-7 5fj0 B 19 2.2 URS000080E16F_2238 27016741 2238 ggcgaagaaccggggagcc ................... ................... Structure of the standard kink turn HmKt-7 as simple duplex in P4222 space group; HMKT-7 5fj0 C 19 2.2 URS000080E16F_2238 27016741 2238 ggcgaagaaccggggagcc ................... ................... Structure of the standard kink turn HmKt-7 as simple duplex in P4222 space group; HMKT-7 5fj1 A 24 2.75 URS0000A76360_2238 27016741 2238 uggggagccgaaaggcgaagaacc .<<...<<<....>>>......>> .((...(((....)))......)) Structure of the standard kink turn HmKt-7 as stem loop in P212121 space group; HMKT-7 5fj1 B 24 2.75 URS0000A76360_2238 27016741 2238 uggggagccgaaaggcgaagaacc .<<...<<<....>>>......>> .((...(((....)))......)) Structure of the standard kink turn HmKt-7 as stem loop in P212121 space group; HMKT-7 5fj1 C 24 2.75 URS0000A76360_2238 27016741 2238 uggggagccgaaaggcgaagaacc .<<...<<<....>>>......>> .((...(((....)))......)) Structure of the standard kink turn HmKt-7 as stem loop in P212121 space group; HMKT-7 5fj1 D 24 2.75 URS0000A76360_2238 27016741 2238 uggggagccgaaaggcgaagaacc .<<...<<<....>>>......>> .((...(((....)))......)) Structure of the standard kink turn HmKt-7 as stem loop in P212121 space group; HMKT-7 5fj1 E 24 2.75 URS0000A76360_2238 27016741 2238 uggggagccgaaaggcgaagaacc .<<...<<<....>>>......>> .((...(((....)))......)) Structure of the standard kink turn HmKt-7 as stem loop in P212121 space group; HMKT-7 5fj1 F 24 2.75 URS0000A76360_2238 27016741 2238 uggggagccgaaaggcgaagaacc .<<...<<<....>>>......>> .((...(((....)))......)) Structure of the standard kink turn HmKt-7 as stem loop in P212121 space group; HMKT-7 5fj1 G 24 2.75 URS0000A76360_2238 27016741 2238 uggggagccgaaaggcgaagaacc .<<...<<<....>>>......>> .((...(((....)))......)) Structure of the standard kink turn HmKt-7 as stem loop in P212121 space group; HMKT-7 5fj1 H 24 2.75 URS0000A76360_2238 27016741 2238 uggggagccgaaaggcgaagaacc .<<...<<<....>>>......>> .((...(((....)))......)) Structure of the standard kink turn HmKt-7 as stem loop in P212121 space group; HMKT-7 5fk5 A 94 3.315 RF00162 URS0000A76359_119072 27016741 0010468 119072 ggcuuaucaagagagggagagcgacuggcgcgaagaaccccggcaaccagaaauggugccaauuccugcagcggaaacguugaaagaugagccg <<<<<<<<......<<<...<<<...((>>>......>>>.<<<<.<<<....>>>>>>>....))..<<<<<....>>>>>...>>>>>>>>. ((((((((....(.(((...(((.[.[[)))......))))(((..(((....))).)))...(]].](((((....)))))..))))))))). SAM-I riboswitch bearing the H. marismortui Kt-7 variant 3bn is AA; SAM-I RIBOSWITCH 5fk6 A 94 2.5 RF00162 URS0000A7635A_119072 27016741 0010468 119072 ggcuuaucaagagagggagagcgacuggcgcgaagacccccggcaaccagaaauggugccaauuccugcagcggaaacguugaaagaugagcca <<<<<<<<......<<<...<<<...((>>>......>>>.<<<<.<<<....>>>>>>>....))..<<<<<....>>>>>...>>>>>>>>. ((((((((....(.(((...(((.[.[[)))......))))(((..(((....))).)))...(]].](((((....)))))..))))))))). SAM-I riboswitch bearing the H. marismortui Kt-7 variant 3bn is CA; SAM-I RIBOSWITCH 5fkd A 94 3.0 RF00162 URS0000A7635B_119072 27016741 0010468 119072 ggcuuaucaagagagggagagcgacuggcgcgaagauccccggcaaccagaaauggugccaauuccugcagcggaaacguugaaagaugagccg <<<<<<<<......<<<<..<<<...((>>>.....>>>>.<<<<.<<<....>>>>>>>....))..<<<<<....>>>>>...>>>>>>>>. ((((((((....(.(((...(((.[.[[)))......))))(((..(((....))).)))...(]].](((((....)))))..))))))))). SAM-I riboswitch bearing the H. marismortui Kt-7 variant 3bn is UA; SAM-I RIBOSWITCH 5fke A 94 2.8 RF00162 URS0000A7638A_119072 27016741 0010468 119072 ggcuuaucaagagagggugagcgacuggcgcgaagagccccggcaaccagaaauggugccaauuccugcagcggaaacguugaaagaugagccg <<<<<<<<......<<<<..<<<...((>>>.....>>>>.<<<<.<<<....>>>>>>>....))..<<<<<....>>>>>...>>>>>>>>. ((((((((....(.((((..(((.[.[[))).....)))))(((..(((....))).)))...(]].](((((....)))))..))))))))). SAM-I riboswitch bearing the H. marismortui Kt-7 variant 3bn is GU; SAM-I RIBOSWITCH 5fkf A 94 2.8 RF00162 URS0000A76399_119072 27016741 0010468 119072 ggcuuaucaagagagggcgagcgacuggcgcgaagauccccggcaaccagaaauggugccaauuccugcagcggaaacguugaaagaugagccg <<<<<<<<......<<<...<<<...((>>>......>>>.<<<<.<<<....>>>>>>>....))..<<<<<....>>>>>...>>>>>>>>. ((((((((......(((...(((.[.[[)))......))).(((..(((....))).)))...(]].](((((....)))))..))))))))). SAM-I riboswitch bearing the H. marismortui Kt-7 variant 3bn is UC; SAM-I RIBOSWITCH 5flx 1 1708 3.9 RF01960,RF01959,RF00177 URS00005A14E2_9986 26604301 0003735 0005840 9986 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucagaucaaaaccaacccgggcuuuggugacucuagauaaccucgggccgaucgcacgccccccguggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcggccccuugccucucgcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgacccccgagcgguaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccguggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<....[[[>>>>>[[[.((((((.....{{.........[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[......{{....[[[[[....<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<<<....>>>>>>...>>>>[[..(((((.....<<<<<<<<<<<.>>....<......>..)))))......]]...<<<<..<<<......>>>.>>>>.]].]]]...}}....]]].<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<...<<<<.....>>>.>>>>......}}.......<<<<<<<<<.<<<....>>>..>>>>>.>>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..)))))).]]]............{{.......{{...[[[.[[....<<<.....>>>....<.<..<....>>.>....<<<<<.<.......<<...<.......>.<<<<.......>>>>...>>......>.>>>..>>............[..((((((.....>>>>>>>>>.))))))...]......]]....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<........>>>>>>>>>.>..>>>...<<..}}>>...>>.....>>>.....<<<.....<<<<<....>>>>>...>>>..]]]...<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<........<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<<<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<.<.<<<<..<<<<..<<..<......>..>>>>>>..>>>>.>>.....<<<<<.....>>>>>........>>>....>>>.>>>...>.>>>>>>>.....>.>>>>>......>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<.<<<<<..>>>>>...>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((.....[[..))))(((.((((((...(.((..((.....(((.(((...(....((....((..........))...)){)........((.......(((.(.(..(.....(((......((.....((..((.....))..))......))..........(((...(.((((....)))).)...)))..(..(((((......[[[[[[[[((.))....(......)..)))))......)..(.(.((.((((......)))))).))...)))....)).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))..((.(((..........))).)).(.((....)).)...)))))).).......(((...(.((.}...))..))))..)...)).).....(.(((((((.(((....)))..))))).)).)......((..(...........)..)).........((((([.....(.((((.....((...])).......))))))))))..)))))).))).........(.({{...(.(.((...(((..(.....((.....)).....(....((..))..)...((((((.(.......((..((.......)).(((.......)))....))......).)))..)))...........(...((.((.....]]]]]]]]..)).))....)......)....(((.(((..(...((((..((..((((((((...((........))......))))))))..)).......((....))...))))..)..)))..))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..(.((((((.((.(......).)))))))).)..)))...((..}}))...)).....))))).).(((......((((....))))....)))...]]...(.((..(((((((..((..(((((..(((.((((((......((........))..........(((((.(....((((((.......((.(((........))).)).....))))))...((.(((...(.((((((.(..(((.(((((....)))..(.((......)))...)).)))....(((...(.(.((((...(((...(..(......)..).)))...))))).).....(((((.....)))))........))).)..))).))).....).))))).....).)))))...)).)))).))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....((((((((.......))))))))......))...))))))).))..)..(.(..((.(..((((.((..(.((((((((.(((..((((.((...(((((.(((((..)))))...)))))...)).))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>........ Mammalian 40S HCV-IRES complex; 18S RRNA 5flx z 264 3.9 RF00061,RF00620 URS000080E1FF_11103 26604301 0043022 0006417 11103 ccugugaggaacuacugucuucacgcagaaagcgucuagccauggcguuaguaugagugucgugcagccuccaggacccccccucccgggagagccauaguggucugcggaaccggugaguacaccggaaugauuugggcgugcccccgcaagacugcuagccgaguaguguugggucgcgaaaggccuugugguacugccugauagggugcuugcgagugccccgggaggucucguagaccgugcaccaugagcacgaauccu <<<<.<<<<.....<<<<<..<<<.<<....<<<<<.......>>>>>.....>>.>>>..>.>>>>>>>>>>>>......<<<<<<<<<<<.<<<<<<<<<<<<<<<<<..<<<<<......>>>>><<<.>>>.<<<....>>>>>>>.>>>>>>>>><<<.....<<<......>>>....>>>....>>>>.>><<<<....>>>><<..(((((.>>>>>>>>>>>.)))))........................... ((((.((((.....(((((..(((.((....(((((.......))))).....)).)))..).))))))))))))......(((((((((((.(((((((.(((((((((..((((((....))))))(((.))).((......)))))).))))).)))(((.....((........))....)))(..)))))[))((((..].))))((..[[[[[.))))))))))).]]]]]........................... Mammalian 40S HCV-IRES complex; HCV-IRES 5g2x A 692 3.8 RF00029 URS0000A76354_1358 27136327 0000373 1358 gugcgcccagauaggguguuaagucaaguaguuuaagguacuacucuguaagauaacacagaaaacagccaaccuaaccgaaaagcgaaagcugauacgggaacagagcacgguuggaaagcgaugaguuaccuaaagacaaucggguacgacugagucgcaauguuaaucagauauaagguauaaguuguguuuacugaacgcaaguuucuaauuucgguuaugugucgauagaggaaagugucugaaaccucuaguacaaagaaagguaaguuaugguuguggacuuaucuguuaucaccacauuuguacaaucuguaggagaaccuaugggaacgaaacgaaagcgaugccgagaaucugaauuuaccaagacuuaacacuaacuggggauacccuaaacaagaaugccuaaaggaggaaaaaggcuauagcacuagagcuugaaaaucuugcaaggguacggaguacucguaguagucugagaaggguaacgcccuuuacauggcaaagggguacaguuauuguguacuaaaauuaaaaauugauuagggaggaaaaccucaaaccaacaauggcaauuuuagacaauaacagagccguauacuccgagagggguacguacgguucccgaagaggguggugcaaaccagucacaguaaugugaacaaggcgguaccucccuacuucac ......<<.<.....<<<<<<<<<...<<<<.........>>>><<<<<....((((>>>>>.((((..<<<<<...<<.....<......>......>>...........>>>>>....((((..((((......<<<<<.........))))...))))..))))...[[[[............<<.......>>......{..{.[[........................(((....>>>>>....)))......<.<<<...<<<..<.<.........>..>.>>>.))))........>>>>........<<<<<....>>>>>........]]}....}............]]]]...........>>>>>>>>.>...>.>>..<<<<<<...<<<<....<<<..>>>........<<<<..........>>>>.......>>>>..>>>>>>....<<<<<..............<.<<<.....>>.>>.............>>>>>.<<<<<<<....<<<<<<<<....<<<.........<<.....>>.........>>>...>>>>>>>>.>>>>>>>..........<<<<......>>>>..............<<<.<<<.<<<<....<....<<<<....>>>>......>...>>>>..>>>.>>>... ......(..(......((((.(((...((((.........))))((.(......[[..).))...(...((((...........((....))....................)))).....(((..(((.......[[.[[..........)))...)))....).....((((........(....................(...((.........(.........)....(((.....]].]].....))).....(((.(.....(.((((.........)))).)....]].........))))........(((........)))........)).....)...)........))))...........))).)))).....).)...(.((.....(.((....(((..)))........(((...(....)...))).......)).)...))..).....((..............................................))...(((((((.....((((.(.....((..........(.....)..........))....).))))..)))))))..........(((..(....)..))..).............(...(....((.........(((....)))..........))....)....)..... Structure a of Group II Intron Complexed with its Reverse Transcriptase; GROUP II INTRON 5g2x B 12 3.8 URS0000A76362_1359 27136327 1359 cacauccauaac ............ ............ Structure a of Group II Intron Complexed with its Reverse Transcriptase; 5'-R(*CP*AP*CP*AP*UP*CP*CP*AP*UP*AP*AP*CP)-3' 5g4t A 11 2.751 URS0000A7633C_2238 27506301 2238 ggcgaagaacu ........... ........... The structure of a quasi-cyclic six k-turn duplex RNA species; HMKT-7 5g4u A 19 2.65 URS0000A76392_2238 27506301 2238 ggcgaagauccggugagcc ................... ................... Association of three two-k-turn units based on Kt-7 3bU,3nU, forming a triangular-shaped structure; HMKT-7 5g4u B 19 2.65 URS0000A76392_2238 27506301 2238 ggcgaagauccggugagcc ................... ................... Association of three two-k-turn units based on Kt-7 3bU,3nU, forming a triangular-shaped structure; HMKT-7 5g4u E 19 2.65 URS0000A76392_2238 27506301 2238 ggcgaagauccggugagcc ................... ................... Association of three two-k-turn units based on Kt-7 3bU,3nU, forming a triangular-shaped structure; HMKT-7 5g4u F 19 2.65 URS0000A76392_2238 27506301 2238 ggcgaagauccggugagcc ................... ................... Association of three two-k-turn units based on Kt-7 3bU,3nU, forming a triangular-shaped structure; HMKT-7 5g4u I 19 2.65 URS0000A76392_2238 27506301 2238 ggcgaagauccggugagcc ................... ................... Association of three two-k-turn units based on Kt-7 3bU,3nU, forming a triangular-shaped structure; HMKT-7 5g4u J 19 2.65 URS0000A76392_2238 27506301 2238 ggcgaagauccggugagcc ................... ................... Association of three two-k-turn units based on Kt-7 3bU,3nU, forming a triangular-shaped structure; HMKT-7 5g4v A 19 2.87 URS0000A7634B_2238 27506301 2238 ggcgaagagccggcgagcc ................... ................... Association of four two-k-turn units based on Kt-7 3bG,3nC, forming a square-shaped structure; HMKT-7 5g4v B 19 2.87 URS0000A7634B_2238 27506301 2238 ggcgaagagccggcgagcc ................... ................... Association of four two-k-turn units based on Kt-7 3bG,3nC, forming a square-shaped structure; HMKT-7 5g4v E 19 2.87 URS0000A7634B_2238 27506301 2238 ggcgaagagccggcgagcc ................... ................... Association of four two-k-turn units based on Kt-7 3bG,3nC, forming a square-shaped structure; HMKT-7 5g4v F 19 2.87 URS0000A7634B_2238 27506301 2238 ggcgaagagccggcgagcc ................... ................... Association of four two-k-turn units based on Kt-7 3bG,3nC, forming a square-shaped structure; HMKT-7 5gad A 2883 3.7 RF02540,RF02541 URS000080E25C_562 26804923 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggguuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>...[.....<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))....].]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<..>>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<..>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<.>>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<<.<<....>>..>>>>>>..>.....>>>>>>>>..>>>>><<<<<<...>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<..<<<............<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>.>>..>>>..>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))((((((((..)))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((()))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((()).))...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((.((((.)))).))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.....)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((..(................((...((......(((.((((....)))).)))...)).............)).......)..)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). RNC-SRP-SR complex early state; 23S rRNA 5gad B 120 3.7 RF00001 URS0000049E57_562 26804923 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). RNC-SRP-SR complex early state; 5S rRNA 5gae A 2884 3.33 RF02540,RF02541 URS000080E25C_562 26804923 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaaggggguacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccgcgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<.<<<..>>>.>....>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<.<<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>>>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<.>>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>..>.....>>>>>>>>..>>>>><<<<..>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<..<<<............<<<<<...<<<<....<<<<<<<<....>>>>>>>>.>>>>.............>>>.>>..>>>..>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>.(<<...<<<<<<<...<<<<<<.......>>>>>>.....<<)..(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))((((((((..)))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(..((()))..)....)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(...((......)).).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((((((.)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))((((()))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((..(...(...........(((...((......((((.(((....))).))))...)).............)))..)...)..)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). RNC in complex with a translocating SecYEG; 23S rRNA 5gae B 120 3.33 RF00001 URS0000049E57_562 26804923 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). RNC in complex with a translocating SecYEG; 5S rRNA 5gaf A 2883 4.3 RF02540,RF02541 URS00008FED41_562 26804923 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggguuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>...[.....<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))....].]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<..>>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<..>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<.>>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<<.<<....>>..>>>>>>..>.....>>>>>>>>..>>>>><<<<<<...>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<..<<<............<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>.>>..>>>..>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))((((((((..)))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((()))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((()).))...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((.((((.)))).))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.....)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((..(................((...((......(((.((((....)))).)))...)).............)).......)..)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). RNC in complex with SRP; 23S ribosomal RNA 5gaf B 120 4.3 RF00001 URS0000049E57_562 26804923 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). RNC in complex with SRP; 5S ribosomal RNA 5gag A 2883 3.8 RF02540,RF02541 URS000080E25C_562 26804923 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggguuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>...[.....<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))....].]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<..>>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<..>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<.>>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<<.<<....>>..>>>>>>..>....>>>>>>>>>..>>>>><<<<<<...>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<..<<<............<<<<<...<<......<<<<<<<<....>>>>>>>>...>>.............>>>.>>..>>>..>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))((((((((..)))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((()))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(.(())..)...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((((((.)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.....)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((..(...(............(....((......((((.(((....))).))))...))..............)...)...)..)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). RNC in complex with SRP-SR in the closed state; 23S rRNA 5gag B 120 3.8 RF00001 URS0000049E57_562 26804923 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). RNC in complex with SRP-SR in the closed state; 5S rRNA 5gah A 2883 3.8 RF02540,RF02541 URS000080E25C_562 26804923 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggguuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>...[.....<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))....].]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<..>>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<..>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<.>>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<<.<<....>>..>>>>>>..>.....>>>>>>>>..>>>>><<<<<<...>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<..<<<............<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>.>>..>>>..>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))((((((((..)))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((()))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((()).))...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((.((((.)))).))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.....)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((..(................((...((......(((.((((....)))).)))...)).............)).......)..)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). RNC in complex with SRP with detached NG domain; 23S rRNA 5gah B 120 3.8 RF00001 URS0000049E57_562 26804923 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). RNC in complex with SRP with detached NG domain; 5S rRNA 5gak 1 3165 3.88 RF02540,RF02543 URS000061F377_4932 26715760 0003735 0005840 4932 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauagagggcuaccuuuauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<.<<<<<<<<<<<<<<<<<<<<<.....<<<<......>>>>.((......<<<.....))>>>....>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<......<<<<<<<<<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<<..>>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>....>>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<..<.<<<<<..<<<<<<.....>>>>>>>>>>>.>..>>>..>>.>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<........<<<<<.<<<...<<.........>>...>>>......................>>>>>....>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><<<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>.>>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<.<.....<<<....>>>...<...<<<<<<...<<<<.<<<<<<<<<<<<<<<<<<..{{{..>>>>>>....<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>.....<<<<<<<<....>>>>>>>>>>>>.>.>>>>>>>.>>>>.........>>>>>>...>......>.>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<....<....>.....>>>>><<.<<<<<<<<<<<....>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<...<<....<<<<<....>>>>.>...>>.>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<<<<<<<<<..>..>>>>>>.>>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<......>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<<...<<<<<<<<<<}}}.>>>>>..>>>>>..>>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<.<..<<<<<......>>>>>..>>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((..........[..........)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((.(((.(((((.(.(((((.(((((((....{((((......)))).[[(...).(((....}]])))....)))))))...))))).).....)))))))).))...)....(((((((........))))))).....((.((..[[[.[[)).))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((.(((...(...(((((....)))))..).....))).))).....))))).))))))))))........(((....)))....))))))))....)))))).)))))..((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(.(((..(((((....)))))...))).).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...).)))...(((..((.((........)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((....(((.(..(.((((.....)))).).))))....)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.(((((((((......{.(((((.(((...((.........))...))).....(...(........).).)))))....))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))((((((((((.((.......(((.((((....)))))))....)))))))))).)).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[((..((...((....(((....)))........(..(((........).)).)....))....))...(((((........)))))]]((((..((((..(...((((....)))...(.[.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....)..)..))).))))..))..)).....((......)).)))).((((.....))))..))))..((.(.....(((((((.((.......(.......(((((....(.[..).....)))))((.(((((((((((....)))))..)))))).))(...).......(((((((((...((.........))....((((((....((((.....))))......))))))..].(((.(((..((((((.....((.....((((....)))).....))..))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)...)).)))))))..).))))....)).[..(((((......].)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((((((((.((.()...)).))).))))))))))....((((.....((((..((((........))))...........]....(((((....)))))...))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))).)..(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]].]]]))))))))))....)}....))))..)))))).......((.(...((((((...((.......))...))))))....).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(..((.(....).).)..)....))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)((((....((((....((((((((((}}..)))))..)))))...))))...)))).((((...((((.....}.......))))...)))).))))....)))))))).......(.((((.(((.((....((.(........((((.((..).).)))).....))).......((.(((...(((.(.(..(((......)))..).).))).))).)).............)).))).)))).)..(((((.(..(.......)..).....(((((((((.(((....((((.(..(((.((..)..).)))..)))))...)))....)))).)))))..))))).. Yeast 60S ribosomal subunit with A-site tRNA, P-site tRNA and eIF-5A; 25S rRNA 5gak 3 121 3.88 RF00001 URS000055688D_4932 26715760 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<....<<<.<<<............>>>....>>...>>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. ((((((.((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....)))))))).)))))). Yeast 60S ribosomal subunit with A-site tRNA, P-site tRNA and eIF-5A; 5S rRNA 5gak 4 158 3.88 RF00002 URS00001BF64E_4932 26715760 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....)))....((.((((.....]]............).)))..).).)))....((.....))(((((((((....)))))))))..................... Yeast 60S ribosomal subunit with A-site tRNA, P-site tRNA and eIF-5A; 5.8S rRNA 5gak A 76 3.88 RF00005 URS000042DDAB_4932 26715760 0030533 0006412 4932 gggucguuagcucaguugguagagcaguugacuuuuaaucaauuggucgcagguucgaauccugcacgacccacca <<<<<<<..<<<<........>>>><<<<<<.......>>>>>>.....<<<.........>>>.>>>>>>>.... ((((((...(((..........)))(.((((.......)))).).....(..(.......)..)..)))))).... Yeast 60S ribosomal subunit with A-site tRNA, P-site tRNA and eIF-5A; The A-site tRNA was modeled based on an E. coli tRNA-Lys 5gak B 77 3.88 RF00005 URS000009EE82_4932 26715760 0030533 0006412 4932 ggagcgguaguucagucgguuagaauaccugccugucacgcagggggucgcggguucgagucccguccguuccgcca <<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((.(((...(((.........)))..(((((.......)))))......((((.......)))).))).))).... Yeast 60S ribosomal subunit with A-site tRNA, P-site tRNA and eIF-5A; P-site tRNA 5gam U 141 3.7 RF00020 URS00008FED40_4932 26829225,26106855 0000244,0000353 0005682,0046540 4932 cagcuuuacagaucaauggcggagggaggucaacaucaagaacugugggcgccuauagaacuuauaacgaacaugguucuugccuuuuaccagaaccauccggguguugucuccauagaaacagguaaagcuguauuuuuu <<<<<<<<<.......<.......<<<<<.<<<<<<<<<<..<<<<<<<..>>>>>>>..>>>.........<<<<<<<<...........>>>>>>>>...>>>>>>>>>>>>......>...>>>>>>>>>........ (((((((((.......(.......((((..((((((((((..(((((((())))))))..))).....(...((((((((...........)))))))).).))))))).))))......)...)))))))))........ Foot region of the yeast spliceosomal U4/U6.U5 tri-snRNP; U5 snRNA 5gam W 25 3.7 URS00008FED47_4932 26829225,26106855 4932 guucgcgaacuucguggacauuugg <<<<<<<<<.>>>>>>>>>...... (((((((((.)))))))))...... Foot region of the yeast spliceosomal U4/U6.U5 tri-snRNP; U6 snRNA, 5' end 5gan V 124 3.7 RF00015 URS00001143F5_4932 26829225,26106855 0017070 0000244,0000353 0005687,0046540 4932 auccuuaugcacgggaaauacgcauaucagugaggauucguccgagauuguguuuuugcugguugaaauuauaaaccagaccgucuccucauggucaaucaagacuauguagggaauuuuugga ...................<<<<<.<<<.....<<<....>>>..>>>>>>>>.................................<<<.<<<<<<......>>>>>>..>>>........... ...................(((((.(((.....(((....)))..))))))))..................................(((((.(((......))).))).))............ The overall structure of the yeast spliceosomal U4/U6.U5 tri-snRNP at 3.7 Angstrom; U4 snRNA 5gan W 80 3.7 RF00026 URS00006184A9_4932 26829225,26106855 0030621 0000244,0000353 0005688,0046540 4932 guucgcgaacuucguggacauuuggucaauuugaauacagagaucagcaguuccccugcauaaggaugaaccguuguuuu <<<<<<<<<.>>>>>>>>>.........<<<..>>>............................................ (((((((((.))))))))).......(.(((..)))...)........................................ The overall structure of the yeast spliceosomal U4/U6.U5 tri-snRNP at 3.7 Angstrom; U6 snRNA 5gan U 141 3.7 RF00020 URS000053F313_4932 26829225,26106855 0000244,0000353 0005682,0046540 4932 cagcuuuacagaucaauggcggagggaggucaacaucaagaacugugggcgccuauagaacuuauaacgaacaugguucuugccuuuuaccagaaccauccggguguugucuccauagaaacagguaaagcuguauuuuuu <<<<<<<<<.......<.......<<<<<.<<<<<<<<<<..<<<<<<<..>>>>>>>..>>>.........<<<<<<<<...........>>>>>>>>...>>>>>>>>>>>>......>...>>>>>>>>>........ (((((((((.......(.......((((..((((((((((..(((((((())))))))..))).....(...((((((((...........)))))))).).))))))).))))......)...)))))))))........ The overall structure of the yeast spliceosomal U4/U6.U5 tri-snRNP at 3.7 Angstrom; U5 snRNA 5gap V 67 3.6 RF00015 URS00008FED2F_4932 26829225 0017070 0000244,0000353 0005687,0046540 4932 auccuuaugcacgggaaauacgcauaucagugaggauucguccgagauuguguuuuugcugguugaa ...................<<<<<.<<<.....<<<....>>>..>>>>>>>>.............. ...................(((((.(((.....(((....)))..)))))))).............. Body region of the U4/U6.U5 tri-snRNP; U4 snRNA, 5' region, nucleotides 1-67 5gap W 56 3.6 RF00026 URS00006184A9_4932 26829225 0030621 0000244,0000353 0005688,0046540 4932 auuuggucaauuugaauacagagaucagcaguuccccugcauaaggaugaaccguu .........<<<..>>>....................................... .......(.(((..)))...)................................... Body region of the U4/U6.U5 tri-snRNP; U6 snRNA 5gap U 20 3.6 RF00020 URS000053F313_4932 26829225 0000244,0000353 0005682,0046540 4932 uucuugccuuuuaccagaac <<<<...........>>>>. ((((...........)))). Body region of the U4/U6.U5 tri-snRNP; U5 snRNA 5gin G 35 3.308 URS000080DD2E_2287 27625427 2287 gggagucuugugaugaaacacucauggucugaaga ................................... ................................... Crystal structure of box C/D RNP with 12 nt guide regions and 9 nt substrates; C/D RNA 5gin H 32 3.308 URS000080DD2E_2287 27625427 2287 ugugaugaaacacucauggucugaagacuccc ................................ ................................ Crystal structure of box C/D RNP with 12 nt guide regions and 9 nt substrates; C/D RNA 5gin N 31 3.308 URS000080DD2E_2287 27625427 2287 ucuugugaugaaacacucauggucugaagac ............................... ............................... Crystal structure of box C/D RNP with 12 nt guide regions and 9 nt substrates; C/D RNA 5gio G 35 3.604 URS000080DD2E_2287 27625427 2287 gggagucuugugaugaaacacucauggucugaaga ................................... ................................... Crystal structure of box C/D RNP with 12 nt guide regions and 13 nt substrates; C/D RNA 5gio H 32 3.604 URS000080DD2E_2287 27625427 2287 ugugaugaaacacucauggucugaagacuccc ................................ ................................ Crystal structure of box C/D RNP with 12 nt guide regions and 13 nt substrates; C/D RNA 5gio I 10 3.604 URS0000A7637E_2287 27625427 2287 ccaugagugu .......... .......... Crystal structure of box C/D RNP with 12 nt guide regions and 13 nt substrates; substrate 5gio J 10 3.604 URS0000A7637E_2287 27625427 2287 ccaugagugu .......... .......... Crystal structure of box C/D RNP with 12 nt guide regions and 13 nt substrates; substrate 5gio N 31 3.604 URS000080DD2E_2287 27625427 2287 ucuugugaugaaacacucauggucugaagac ............................... ............................... Crystal structure of box C/D RNP with 12 nt guide regions and 13 nt substrates; C/D RNA 5gio O 10 3.604 URS0000A7637E_2287 27625427 2287 ccaugagugu .......... .......... Crystal structure of box C/D RNP with 12 nt guide regions and 13 nt substrates; substrate 5gip G 31 3.129 URS0000A76373_2287 27625427 2287 ucuugugaugagaacacucauggucugaaga ............................... ............................... Crystal structure of box C/D RNP with 13 nt guide regions and 11 nt substrates; C/D RNA 5gip H 30 3.129 URS0000A76373_2287 27625427 2287 uugugaugagaacacucauggucugaagac .............................. .............................. Crystal structure of box C/D RNP with 13 nt guide regions and 11 nt substrates; C/D RNA 5gip I 11 3.129 URS0000A7639F_2287 27625427 2287 ccaugaguguu ........... ........... Crystal structure of box C/D RNP with 13 nt guide regions and 11 nt substrates; substrate 5gip J 11 3.129 URS0000A7639F_2287 27625427 2287 ccaugaguguu ........... ........... Crystal structure of box C/D RNP with 13 nt guide regions and 11 nt substrates; substrate 5gip Q 31 3.129 URS0000A76373_2287 27625427 2287 ucuugugaugagaacacucauggucugaaga ............................... ............................... Crystal structure of box C/D RNP with 13 nt guide regions and 11 nt substrates; C/D RNA 5gip R 29 3.129 URS0000A76373_2287 27625427 2287 uugugaugagaacacucauggucugaaga ............................. ............................. Crystal structure of box C/D RNP with 13 nt guide regions and 11 nt substrates; C/D RNA 5gip S 11 3.129 URS0000A7639F_2287 27625427 2287 ccaugaguguu ........... ........... Crystal structure of box C/D RNP with 13 nt guide regions and 11 nt substrates; substrate 5gip T 11 3.129 URS0000A7639F_2287 27625427 2287 ccaugaguguu ........... ........... Crystal structure of box C/D RNP with 13 nt guide regions and 11 nt substrates; substrate 5gm6 D 117 3.5 RF00020 URS000053F313_4932 27445306 0000244,0000353 0005682,0046540 4932 ggaggucaacaucaagaacugugggccuuugccuauagaacuuauaacgaacaugguucuugccuuuuaccagaaccauccggguguugucuccauccauauuuuuuggaacuuuuc <<<<<.<<<<<<<.....<<<<<<<<....>>>>>>>>..............<<<<<<<<...........>>>>>>>>...>>>>>>>>>>>>....................... (((((.(((((((.....((((((((....)))))))).........((...((((((((.(.......).)))))))).))))))))))))))....................... Cryo-EM structure of the activated spliceosome (Bact complex) at 3.5 angstrom resolution; Saccharomyces cerevisiae strain CDRDR_sf_H chromosome VII sequence 5gm6 E 103 3.5 RF00026 URS00006184A9_4932 27445306 0030621 0000244,0000353 0005688,0046540 4932 guucgcgaaguaacccuucguggacauuuggucaauuugaaacaauacagagaugaucagcaguuccccugcauaaggaugaaccguuuuacaaagagauuua <<<<<<<<<<.....>>>>>>>>>>.....................................<<<..<<<.....>>>...>>>................... ((.(((((((.....))))))).)).....................................(((.((((.....)))..))))................... Cryo-EM structure of the activated spliceosome (Bact complex) at 3.5 angstrom resolution; Saccharomyces cerevisiae strain T.52_2H chromosome XII sequence 5gm6 L 66 3.5 RF00004 URS000023C730_559292 27445306 0045131 0000348 0005686 559292 acgaaucucuuugccuuuuggcuuagaucaaguguaguaucuguucuuuucaguguaacaacugaa ................................................<<<<<<......>>>>>> ................................................((((((......)))))) Cryo-EM structure of the activated spliceosome (Bact complex) at 3.5 angstrom resolution; U2 snRNA 5gm6 N 25 3.5 27445306 559292 aauuuuuaagguauguauuuuuuuu ......................... ......................... Cryo-EM structure of the activated spliceosome (Bact complex) at 3.5 angstrom resolution; Pre-mRNA 5gm6 M 50 3.5 27445306 559292 aaaaaaaaaaaaaaaaaacuagauacuaacacauuuaauuuuuuuuuguu .................................................. .................................................. Cryo-EM structure of the activated spliceosome (Bact complex) at 3.5 angstrom resolution; Pre-mRNA 5gmk D 117 3.4 RF00020 URS000053F313_559292 27445308 0000244,0000353 0005682,0046540 559292 ggaggucaacaucaagaacugugggccuuugccuauagaacuuauaacgaacaugguucuugccuuuuaccagaaccauccggguguugucuccauccauauuuuuuggaacuuuuc <<<<<.<<<<<<<.....<<<<<<<<....>>>>>>>>..............<<<<<<<<...........>>>>>>>>...>>>>>>>>>>>>....................... (((((.(((((((.....((((((((....)))))))).........((...((((((((.(.......).)))))))).))))))))))))))....................... Cryo-EM structure of the Catalytic Step I spliceosome (C complex) at 3.4 angstrom resolution; U5 snRNA 5gmk E 103 3.4 RF00026 URS00006184A9_559292 27445308 0030621 0000244,0000353 0005688,0046540 559292 guucgcgaaguaacccuucguggacauuuggucaauuugaaacaauacagagaugaucagcaguuccccugcauaaggaugaaccguuuuacaaagagauuua <<<<<<<<<<.....>>>>>>>>>>.....................................<<<..<<<.....>>>...>>>................... ((((.(((((.....))))).))))......................................((.((((.....)))..))).................... Cryo-EM structure of the Catalytic Step I spliceosome (C complex) at 3.4 angstrom resolution; U6 snRNA 5gmk L 127 3.4 RF00004 URS000023C730_559292 27445308 0045131 0000348 0005686 559292 acgaaucucuuugccuuuuggcuuagaucaaguguaguaucuguucuuuguaacaacuaaugaccucagaggcucaauuuguuacaauacauuuuuuggcaccgcgacccucgcacuuguggagucg ................................................<<<<<<<<.<...<.<<<<.>>>>.>..>.>>>>>>>>................<<...<<...........>>...>> ................................................((((((((.(.....((((.))))....).))))))))................((...(.............)...)) Cryo-EM structure of the Catalytic Step I spliceosome (C complex) at 3.4 angstrom resolution; U2 snRNA 5gmk M 29 3.4 URS0000A7633B_559292 27445308 559292 uuuuaagaacuagauacuaacacauuuuu ............................. ............................. Cryo-EM structure of the Catalytic Step I spliceosome (C complex) at 3.4 angstrom resolution; Intron_BPS 5gmk B 13 3.4 URS0000A763A3_559292 27445308 559292 auaaauuuuuaag ............. ............. Cryo-EM structure of the Catalytic Step I spliceosome (C complex) at 3.4 angstrom resolution; 5'-Exon 5gmk N 15 3.4 URS0000A7639B_559292 27445308 559292 guauguauuuauuuu ............... ............... Cryo-EM structure of the Catalytic Step I spliceosome (C complex) at 3.4 angstrom resolution; 5'-Splicing Site 5h0r H 42 3.9 URS0000B21E05_10981 27914893 10981 aaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa .......................................... .......................................... RNA dependent RNA polymerase ,vp4,dsRNA; RNA (42-MER) 5h0r I 42 3.9 URS000080E0BB_10981 27914893 10981 uuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuu .......................................... .......................................... RNA dependent RNA polymerase ,vp4,dsRNA; RNA (42-MER) 5h1s A 2799 3.5 RF02540,RF02541 URS000028B73E_3562 27762343 0003735 0005840 3562 uucaaacgaggaaaggcuuacgguggauaccuaggcacccagagacgaggaagggcguauuaaucgacgaaaugcuucggggaguugaaaauaagcagagauccggagauucccgaauaggucaaccuuucgaacuucugcugaauccaugggcaggcaagagacaaccuggcgaacugaaacaucuuaguagccagaggaaaagaaagcaaaagcgauucccguaguagcggcgagcgaaaugggagcagccuaaaccgugaaaacgggguugugggagagcaauacaagcgucgugcugcuaggcgaaucaguggagugcggaacccuagauggugaaaguccaguagccgaaagcaucacuagcuuaugcucugacccgaguagcauggggcacguggaaucccgugugaaucagcaaggaccaccuugcaaggcuaaauacuccugggugaccgauagcgaaguaguaccgugagggaagggugaaaagaacccccaucggggagugaaauagaacaugaaaccguaagcucucaagcagugggagggggaacccugaccgcgugccuguugaagaaugagccggcgacucauaggcaguggcuugguuaagggaacccaccggagccguagcgaaagcgagucuucauagggcaauugucacugcuuauggacccgaaccugggugaucuauccaugaccaggaugaagcuugggugaaacuaaguggagguccgaaccgacugauguugaagaaucagcggaugaguugugguuaggggugaaaugccacucgaacccagagcuagcugguucuccccgaaaugcguugaggcgcagcaguugacuggacaucuagggguaaagcacuguuucggugcgggccgcgagagcgguaccaaaucgaggcaaacucugaauacuagauaugaccuccaaauaacaggggucaaggucggccagugagacgaugggggauaagcuucaucgucgagagggaaacagcccggaucaccagcuaaggccccuaaaugaccgcucagugauaaaggagguaggggugcagagacagccaggagguuugccuagaagcagccacccuugaaagagugcguaauagcucacugaucgagcgcucuugcgccgaagaugaacggggcuaagcggucugccgaagcugugggauguaaaaaaacaucgguaggggagcguuccguguuagggagaaacgcgugcgugagccgcguuggacgaagcggaagcgagaaugucggcuugaguaacgcaaacauuggugagaauccaaugccccgaaaaccuaaggguuccuccgcaagguucguccacggagggugagucagggccuaagaucaggccgaaaggcguagucgauggacaacaggugaauauuccuguacuaccccuuguuggucccgagggacggaggaggcuagguuagccgaaagaugguuaucgguucaaggacgcaaggugacccugggguaagaagggguagagaaaaugccucgagccaauguucgaguaccaggcgcuacggcgcugaaguaaccgaugccauacucccaggaaaagcucgaacgaccuucaacaaaaggguaccuguacccgaaaccgacacagguagguagguagagaauaccuaggggcgcgagacaacucucucuaaggaacucggcaaaauagccccguaacuucgggagaaggggugcccccucacaaagggggucgaagugaccaggcccgggcgacuguuuaccaaaaacacaggucuccgcaaagucguaagaccauguaugggggcugacgccugcccagugccggaaggucaaggaaguuggugaccugaugacaggggagccggcgaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgacccgcacgaaaggcguaacgaucugggcacugucucggagagaggcucggugaaauagacaugucugugaagaugcggacuaccugcaccuggacagaaagacccuaugaagcuuuacuguucccugggauuggcuuugggcuuuuccugcgcagcuuagguggaaggcgaagaaggcccccuuccgggggggcccgagccaucagugagauaccacucuggaagagcuagaauucuaaccuugugucaggaccuacgggccaagggacauucucagguagacaguuucuauggggcguaggccucccaaaagguaacggaggcgugcaaagguuuccucgggccggacggagauuggcccucgagugcaaaggcagaagggagcuugacugcaagacccacccgucgagcagggacgaaagucggccuuagugauccgacggugccgaguggaagggccgucgcucaacggauaaaaguuacucuagggauaacaggcugaucuuccccaagaguucacaucgacgggaagguuuggcaccucgaugucggcucuucgccaccuggggcuguaguauguuccaaggguugggcuguucgcccauuaaagcgguacgugagcuggguucagaacgucgugagacaguucgguccauauccggugugggcguuagagcauugagaggaccuuucccuaguacgagaggaccgggaaggacgcaccucugguguaccaguuaucgugcccacgguaaacgcuggguagccaagugcggagcggauaacugcugaaagcaucuaaguaguaagcccaccccaagaugagugcucuccua ..............<<<<<<<<<<.....<<..<<<<<<<<<<<........<<<<<<.....((.>>>.....<<<<<<.<.<<.))......>>.....>>>>>>>...>>>....<<<....>>>........<<<<.............>>>>..........<<<<<<.....<......>......>>>>>.>...<.....<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<....<<<<....>>>>.......<<.<<<<......<<<...<<<.<<<<.<<<...<<.<<.....>>.>>((......<<<.....))>>>...>>>...>>>>.>>>..>>>...>>>>...>>......<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>..>>>....>.>>.>>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>........<<<<..<<<<...>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<...<<<...<<.......>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>..<<.<...<<<<<<.....<.<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>.>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<.<<<<<<<....<<<<<<.....<<<...<<<<<<<<<..<<...............>>..>>>>>>>>>..>>.>.....>>>>>>..<<<<<<.........>>>>>>..>>>>>>>..>>..<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<<.........<<<.<<....<<.........>>....>>.........<<......>>...>>>.....>>>>>>>>>>.>>..........))).....>>>>>>.>>>...>>>>>>><<<<<......>>>>>....>>>>>><.<<<<<<...........<<<<<.<<....>>>>>>>........>>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<..<<<.<....<<<<....<<<<..<<<..<<<<<<<<<<.....[[[..>>>>><...<<<<<...<..................<<<............>>>.....>..>>>>>....><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>.....>....>.>>...>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.......>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<..<<<<<<..<<<......>>>...>>>>>>..>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<..<......<<<<.<<<<<<..<<<<<..<<<<<<<..<<.<<<.<<<.<<<<<...........<<<<<...<<......<<<<<<<<....>>>>>>>>...>>.............>>>.>>.>>>>>.>>>.>>>.>>...<<<<<.<<<..........>>>>>>>>.....>>>>>>>...>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<..<<<<<<.........>>>>>>....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<.<<<<..<<<<<<<<........>>>>>..>>>.<<<<<.....>>>>>.....>>>>...>...>>>.>>....<<<<<<<....>>>.>>>>....>...>>>>>>>>>>>....<<<<<<<...<.<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]].>>>>>>...>>>>>...>>>>.>>>>>....<<...<<<<<<...........>>>>>>...>>..>>.>.......>>>>>>>.... ..............(((((((((......((..(((((((((((.(......((((((.....[[.))).....((((((...(((]].....)))......))))))...)))....(((....)))(..).....((((...........))))......)....((((((.....(...[..)......))))).).........((....))...((((......((.]...)).....))))...(((.....(........).........(..(((.......((....((.((((.(((...((.((.....)).))[[(...).(((.....]])))...)))...)))).))...))....))).....)........(.(((...[.......))).)........(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((....))))............)......)))))))))......(.((((..((.......))..))))...(.(........).).((((.(....((((.((((((.(..(((...((.......))...)))...((....))..((((.....))))....).)))))).))))...(.(...((((((.....(.((((((((.((((...((((((......))))))...)[)))...(((.((((..........)))))))..).))))))).).(.(((....[)))...).]))))))......).)....(((((....(((((....)))))((.((((((.....((((((.....(((...((..((((....(..(........)...)....))))..))..)).).....))))))..((((((.........))))))...))))))..))..((((((.(((......))).))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((..(.(.((.........(((.(((...((.........))...))).....(...((......)).).))).....)).).)..)).))..........]]].)...))))))))))...)))))))(((((......)))))....))))).(.((((((....(.........((.((....)))).......)...))))))..).....).))))(......((.....((((.(.......).))))((((....(((...((...((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]]((.((..(((.(....(..(....((((..((...((((((((.......{{{....)))(...((((....((....................(...........)......))...))))....)(..(((((....)))))...))))))....))...)))).........)..).....).....)))...)).))))))..)).....((......))..))).((((.....))))..))))..((((....(((((((..((..(....(.......(((((....(.{..).....)))))((((((.......))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..((.((((..(((...((..((((((...((......))....))))))..))...)))))))...)))))(((((.........)))))........((..........(.(((.......))).)..)..)....))))...)).))))))).)..)))..))))))).)))))).....))....(((((........)))))..((((((((.(((..(......((((.((((((..(((((..(((((((.........((.(................(..(....((........(.(((......))).).....))..............)..).......).))..........(.(.(.(.(..........).))..)).....)))))))...)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((..(..]]]]..).))))))).....)}......))))..))))))......(((((.(.(..(((...((.......))...)))..)...)))).).).....(((((.(.((((..(((((.((........)).))..))).((...........)).....))))...)...))).))....(((((((....))).))))....)...)))))))))))[....((((((...(.((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))...)))))...)))).)))))....((....((((.............))))....))..)).)..]....))))))..... Structure of the large subunit of the chloro-ribosome; 23S rRNA 5h1s C 102 3.5 RF02541 URS000000A081_3562 27762343 0003735 0005840 3562 aaggucacggcgagacgagccguuuaucauuacgauaggugucaaguggaagugcagugauguaugcagcugaggcauccuaacagacccacagacuugaac ..<<<<<<<<<.......>>>>>............<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>............. ..(((...(((.......)))..............((((((((.(((....(((((....)))))...)))..))))).)))....)))............. Structure of the large subunit of the chloro-ribosome; Spinach chloroplast 4.5S rRNA 5h1s B 117 3.5 RF00001 URS0000538405_3562 27762343 0003735 0005840 3562 uucugguguccuaggcguagaggaaccacaccaauccaucccgaacuuggugguuaaacucuacugcggugacgauacuguaggggagguccugcggaaaaauagcucgacgccagg ..<<<<<<<.....<<<<<<<<.....<<<<<<..............>>>>.>>....>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>..>>>>>>>. ..(...(.........((((((.....((.((.(............).))..))....))))))....((.......(((((((......))))))).......)).....)...). Structure of the large subunit of the chloro-ribosome; 5S rRNA 5h4p 1 3091 3.07 RF02540,RF02543 URS000061F377_4932 28112732 0003735 0005840 4932 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........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..<<<...<.......<<.<<<<<<...>>>>>>.>>.......>.....<<<<<<<.<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<......>>>..................................<<<<<.<<<<<......<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<......>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<....<....>....>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<......<..........<<<.<<<<<<<<<........<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>....>>>>>>>>>>>>..........))).>....>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..[[[..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<.<<<<<<<<<<.<...>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<...<<....<<<<<....>>>>.>...>>.>>>>>..>>>>><<<<<.........>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<..<<<<<<<..>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))......<<<<<<<..<<<<.))))))>>>>>>>>>>>.........>>>>..>>>>>>.......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<.<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>..>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<.]]]..>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((.(((.((((((((.((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..)))).)))....)))))))).))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((.(....).))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((......((((........)))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((..(.(((((...((((...(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).)).....))))...)))))..((.(...((((((.....((...((((..((((...(((((((....)))))))...)[)))...(((..((.((........)))).)))....))).)..)).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((((((((((...(((.(((((((...............)))))...((((..(((.(......))))..)))).....))))).)))))))).))..((((.(((((.....))))).))))....((.(.....)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{...(((..(.....(.........).....).......................))).....)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((............((((((.......))))))((((.....(((...((...((((((...((.....)).))))))....[[(((.((...((....(((....))).........((...(.....)....)).....))....))...(((((........)))))]]((((..(((((.....((((....))).....<.((((((...((((.((((((((((((((((((..{{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))....)......))..))).)))).)))..)).....((......))..))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((((......))))..)))))).))(...).......(((((((((.].((.........))...(((((((....(((.......)))......))))))).}.(((.(((..((((((.....((.....((((....)))).....))..))))..)))))(..((.........))..)........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))......)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.(.((((((..((.((((..)))).))....((((.....((((..((............))...........>...((((((....))))))..))))..))))......)))))).)..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(..(((.(...((.......))...).)))....)).).)........((((.((.(((..(.(((((((......))))))..).).(((.(.....).))).....))).)..)...))).).....(((((((....))).))))....))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}}.)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......(((.((.(((.((....((.(........((((((.....)))))).....))).......((.(((...((.((....(((......)))....)).)).))).)).............)).))).)).)))..(((((.(..(.......)..).....(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))..))))).. Structural snapshot of cytoplasmic pre-60S ribosomal particles bound with Nmd3, Lsg1, Tif6 and Reh1; 25S ribosomal RNA 5h4p 3 121 3.07 RF00001 URS000055688D_4932 28112732 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((.(((...(....)...)))....))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Structural snapshot of cytoplasmic pre-60S ribosomal particles bound with Nmd3, Lsg1, Tif6 and Reh1; 5S ribosomal RNA 5h4p 4 158 3.07 RF00002 URS00001BF64E_4932 28112732 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<......>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Structural snapshot of cytoplasmic pre-60S ribosomal particles bound with Nmd3, Lsg1, Tif6 and Reh1; 5.8S ribosomal RNA 5h5u 5 76 3.01 RF00005 URS000084076E_562 27906160 0030533 0006412 562 cgcgggguggagcagcugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.....[..)))).(((((.......))))).....(((((..]....)))))))))))..... Mechanistic insights into the alternative translation termination by ArfA and RF2; P-site tRNA 5h5u A 2897 3.01 RF02540,RF02541 URS0000B21DE5_83333 27906160 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaaccauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<.....>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<<..<<<<.......>>>>..>>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<......>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.......<<<<<..<<....>>...>>>>>.......>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<<<<...<<.......<<<<<<<<....>>>>>>>>....>>.............>>>>...>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((.(((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))))))).)))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((.......).))...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(...((......)).).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((((......))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((..(((.(.(..(((.(.........((((....((.......((...((....))...))....))..............)))))).).).).).)))..))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Mechanistic insights into the alternative translation termination by ArfA and RF2; 23S rRNA 5h5u B 120 3.01 RF00001 URS0000049E57_83333 27906160 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Mechanistic insights into the alternative translation termination by ArfA and RF2; 5S Ribosomal RNA 5h5u h 1534 3.01 RF00177,RF01959,RF01960 URS000081169C_83333 27906160 0003735 0005840 83333 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<......>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<.<<<....>>>>>.....<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((..............)).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((.(((...(.....))).))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....(((.((((.......)))).))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((.((((....(..((....)).)......((....))..))))..))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..((.......))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Mechanistic insights into the alternative translation termination by ArfA and RF2; 16S rRNA 5hau 1A 2872 3.0 RF02540,RF02541,RF00002 URS00001698E8_300852 26809677 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<.<<<<<<<...........<<<<<..<<<......<<<.<<<<<..>>>>>.>>>...>>>............>>>>>..>>>>>>>.>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)..)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((..)))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((.(.((.(((......)))..)))..)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{..((.(.(.(...(...........)...).).....(...((......)).).).))....)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((.(((((((((.(......[..(((((..(((......((((..((....))..))))...)))..........].)))))).))))))))).))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..((((.))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of antimicrobial peptide Bac7(1-19) bound to the Thermus thermophilus 70S ribosome; 23S Ribosomal RNA 5hau 1B 120 3.0 RF00001 URS000080DEE8_300852 26809677 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>. .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of antimicrobial peptide Bac7(1-19) bound to the Thermus thermophilus 70S ribosome; 5S Ribosomal RNA 5hau 1a 1495 3.0 RF00177,RF01959,RF01960 URS000080DFED_300852 26809677 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccucgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcggucguaacaagguagcuguaccggaaggugcggcugga .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<...>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<......>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>>.>>...>.....<<<<<<<<<....>>>>>>>>>... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((.(((..))).)))).)))))......(((......((((((((..((...(((((((.(((((....((((.(....).)))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((...))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((((((....))))))).(..(((....)))..).)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))).))...)..)..(((((((((....)))))))))}.. Crystal structure of antimicrobial peptide Bac7(1-19) bound to the Thermus thermophilus 70S ribosome; 16S Ribosomal RNA 5hau 1w 76 3.0 RF00005 URS000041AF00_562 26809677 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of antimicrobial peptide Bac7(1-19) bound to the Thermus thermophilus 70S ribosome; P-site tRNA 5hau 2A 2868 3.0 RF02540,RF02541,RF00002 URS00001698E8_300852 26809677 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<.<<<<<<<...........<<<<<..<<<......<<<<<<<<<..>>>>>>>>>...>>>............>>>>>..>>>>>>>.>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<<..<<.......>>>..>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((..))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((...((((((......)))).))...)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{..((.(..((..((((.......))))..))..........((......))...).))....)))))))))).))..........]]].)....))))))))))...)))))))(((((((())))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........(((((..(((......(((((.((....)).)))))...)))............)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....))))))).(((.))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of antimicrobial peptide Bac7(1-19) bound to the Thermus thermophilus 70S ribosome; 23S Ribosomal RNA 5hau 2B 120 3.0 RF00001 URS000080DEE8_300852 26809677 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> .((((((((((....((((((.(....(((((((...(.....)...))))..)))...).)))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of antimicrobial peptide Bac7(1-19) bound to the Thermus thermophilus 70S ribosome; 5S Ribosomal RNA 5hau 2a 1501 3.0 RF00177,RF01959,RF01960 URS000080DFED_300852 26809677 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcggucguaacaagguagcuguaccggaaggugcggcuggau .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>....<<......>>...>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>>.>>...>.....<<<<<<<<<....>>>>>>>>>.... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((.(((((((...))))))).))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((((((....))))))).(..(((....)))..).)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))).))...)..)..(((((((((....)))))))))}... Crystal structure of antimicrobial peptide Bac7(1-19) bound to the Thermus thermophilus 70S ribosome; 16S Ribosomal RNA 5hau 2w 76 3.0 RF00005 URS000041AF00_562 26809677 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of antimicrobial peptide Bac7(1-19) bound to the Thermus thermophilus 70S ribosome; P-site tRNA 5hbx A 14 1.7 URS0002681414_32630 28058281 32630 nnnnacuuaagucu .............. .............. RNA primer-template complex with 2-methylimidazole-activated monomer analogue-2 binding sites; RNA (5'-R(*(LCC)P*(LCC)P*(LCA)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*U)-3') 5hbx B 14 1.7 URS0002681414_32630 28058281 32630 nnnnacuuaagucu .............. .............. RNA primer-template complex with 2-methylimidazole-activated monomer analogue-2 binding sites; RNA (5'-R(*(LCC)P*(LCC)P*(LCA)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*U)-3') 5hbx C 14 1.7 URS0002681414_32630 28058281 32630 nnnnacuuaagucu .............. .............. RNA primer-template complex with 2-methylimidazole-activated monomer analogue-2 binding sites; RNA (5'-R(*(LCC)P*(LCC)P*(LCA)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*U)-3') 5hbx D 14 1.7 URS0002681414_32630 28058281 32630 nnnnacuuaagucu .............. .............. RNA primer-template complex with 2-methylimidazole-activated monomer analogue-2 binding sites; RNA (5'-R(*(LCC)P*(LCC)P*(LCA)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*U)-3') 5hby A 13 1.18 28058281 32630 nnnnacuuaaguc ............. ............. RNA primer-template complex with 2-methylimidazole-activated monomer analogue-3 binding sites; RNA (5'-R(*(LCC)P*(LCC)P*(LCC)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*C)-3') 5hcp 1A 2746 2.894 RF02540,RF02541,RF00002 URS00001698E8_300852 26809677 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccagcuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<..>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<......>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((.(..(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)))).)))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((.(.((((((......)))).)))..))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{..((.().))....)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((..))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((........)))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..((((.))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of antimicrobial peptide Metalnikowin bound to the Thermus thermophilus 70S ribosome; 23S Ribosomal RNA 5hcp 1B 120 2.894 RF00001 URS000080DEE8_300852 26809677 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>. .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of antimicrobial peptide Metalnikowin bound to the Thermus thermophilus 70S ribosome; 5S Ribosomal RNA 5hcp 1a 1477 2.894 RF00177,RF01959,RF01960 URS000080DFED_300852 26809677 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccucgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccugggccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcggucguaacaagguagcuguaccggaaggugcggcugga .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<...>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>>.>>...>.....<<<<<<<<<....>>>>>>>>>... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((..)))))))).)))))......(((......((((((((..((...(((((((.(((((.....(.((......))..).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((...))))...)))))).).....(.(((...(((........)).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((.(.....).)).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((...(((((((....))))))))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))).))...)..)..(((((((((....)))))))))}.. Crystal structure of antimicrobial peptide Metalnikowin bound to the Thermus thermophilus 70S ribosome; 16S Ribosomal RNA 5hcp 1x 76 2.894 RF00005 URS000041AF00_562 26809677 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of antimicrobial peptide Metalnikowin bound to the Thermus thermophilus 70S ribosome; P-site tRNA 5hcp 2A 2790 2.894 RF02540,RF02541,RF00002 URS00001698E8_300852 26809677 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<..>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<.<<....>>.>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((()))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((.(...((((......))))...)..))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((.(.(((...((([[[...(.((((((.....(.....((..((((((((((........((((.(((...(............)..))).........((......))...))))....)))))))))).))..........]]].)....))))))))))...)))).))(((((((())))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((.(((((..))))).))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(((...)).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal structure of antimicrobial peptide Metalnikowin bound to the Thermus thermophilus 70S ribosome; 23S Ribosomal RNA 5hcp 2B 120 2.894 RF00001 URS000080DEE8_300852 26809677 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>. ..(((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).))))))))).. Crystal structure of antimicrobial peptide Metalnikowin bound to the Thermus thermophilus 70S ribosome; 5S Ribosomal RNA 5hcp 2a 1483 2.894 RF00177,RF01959,RF01960 URS000080DFED_300852 26809677 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccugggccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcggucguaacaagguagcuguaccggaaggugcggcuggau .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>>.>>...>.....<<<<<<<<<....>>>>>>>>>.... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...(((.....))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((((((....))))))))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))).))...)..)..(((((((((....)))))))))}... Crystal structure of antimicrobial peptide Metalnikowin bound to the Thermus thermophilus 70S ribosome; 16S Ribosomal RNA 5hcp 2x 76 2.894 RF00005 URS000041AF00_562 26809677 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of antimicrobial peptide Metalnikowin bound to the Thermus thermophilus 70S ribosome; P-site tRNA 5hcq 1A 2746 2.801 RF02540,RF02541,RF00002 URS00001698E8_300852 26809677 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccagcuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<..>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<......>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((...((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((.(.((((((......)))).)))..))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{..((.().))....)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((.(....).)))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((...)))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal structure of antimicrobial peptide Oncocin d15-19 bound to the Thermus thermophilus 70S ribosome; 23S Ribosomal RNA 5hcq 1B 120 2.801 RF00001 URS000080DEE8_300852 26809677 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of antimicrobial peptide Oncocin d15-19 bound to the Thermus thermophilus 70S ribosome; 5S Ribosomal RNA 5hcq 1a 1477 2.801 RF00177,RF01959,RF01960 URS000080DFED_300852 26809677 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccucgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccugggccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcggucguaacaagguagcuguaccggaaggugcggcugga .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<....>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<...<<<<<<......>>>>>.>...>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<.....>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>>.>>...>.....<<<<<<<<<....>>>>>>>>>... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((())))))))).)))))......(((......((((((((..((...(((((((.(((((.....(..(......)...).....)))))....((((..((((....))))..))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((...))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((...(((.(((....))).))))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))).))...)..)..(((((((((....)))))))))}.. Crystal structure of antimicrobial peptide Oncocin d15-19 bound to the Thermus thermophilus 70S ribosome; 16S Ribosomal RNA 5hcq 1x 76 2.801 RF00005 URS000041AF00_562 26809677 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of antimicrobial peptide Oncocin d15-19 bound to the Thermus thermophilus 70S ribosome; P-site tRNA 5hcq 2A 2790 2.801 RF02540,RF02541,RF00002 URS00001698E8_300852 26809677 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<....>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((..))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((.(.((.(((......)))..)))..))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(.(..(.(.........).)..).).........((......))...)))))...)))))))))).))..........]]].)....))))))))))...)))))))(((((((..)))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((........)))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(..((((.........))))....).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))((((.))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal structure of antimicrobial peptide Oncocin d15-19 bound to the Thermus thermophilus 70S ribosome; 23S Ribosomal RNA 5hcq 2B 120 2.801 RF00001 URS000080DEE8_300852 26809677 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>. ..(((((((((....((((((.(....(.(((((...(.....)...))))..).)...).)))).))(((.......((((((((....)))))))).......))).))))))))).. Crystal structure of antimicrobial peptide Oncocin d15-19 bound to the Thermus thermophilus 70S ribosome; 5S Ribosomal RNA 5hcq 2a 1483 2.801 RF00177,RF01959,RF01960 URS000080DFED_300852 26809677 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccugggccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcggucguaacaagguagcuguaccggaaggugcggcuggau .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>>>>>>>>..<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>....>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>>.>>...>.....<<<<<<<<<....>>>>>>>>>.... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......(((......))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((((((....))))))))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))).))...)..)..(((((((((....)))))))))}... Crystal structure of antimicrobial peptide Oncocin d15-19 bound to the Thermus thermophilus 70S ribosome; 16S Ribosomal RNA 5hcq 2x 76 2.801 RF00005 URS000041AF00_562 26809677 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of antimicrobial peptide Oncocin d15-19 bound to the Thermus thermophilus 70S ribosome; P-site tRNA 5hcr 1A 2746 2.8 RF02540,RF02541,RF00002 URS00001698E8_300852 26809677 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccagcuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<..>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<......>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((...((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((.(.((((((......)))).)))..)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{..((.().))....)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((((....)))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..(((...)))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of antimicrobial peptide Oncocin 10wt bound to the Thermus thermophilus 70S ribosome; 23S Ribosomal RNA 5hcr 1B 120 2.8 RF00001 URS000080DEE8_300852 26809677 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of antimicrobial peptide Oncocin 10wt bound to the Thermus thermophilus 70S ribosome; 5S Ribosomal RNA 5hcr 1a 1477 2.8 RF00177,RF01959,RF01960 URS000080DFED_300852 26809677 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccucgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccugggccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcggucguaacaagguagcuguaccggaaggugcggcugga .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<...<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<...<<<<<<......>>>>>.>...>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<...>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>...>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>>.>>...>.....<<<<<<<<<....>>>>>>>>>... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((())))))))).)))))......(((......((((((((..((...(((((((.(((((....(...(......)...).....)))))....((((..((((....))))..))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((...))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((...(((.(((....))).))))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))).))...)..)..(((((((((....)))))))))}.. Crystal structure of antimicrobial peptide Oncocin 10wt bound to the Thermus thermophilus 70S ribosome; 16S Ribosomal RNA 5hcr 1x 76 2.8 RF00005 URS000041AF00_562 26809677 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of antimicrobial peptide Oncocin 10wt bound to the Thermus thermophilus 70S ribosome; P-site tRNA 5hcr 2A 2790 2.8 RF02540,RF02541,RF00002 URS00001698E8_300852 26809677 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<..>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<....>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> .((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((.(..(((...(((.....)))...)))...((....))..((((.....))))....((..))...).)))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((.(..(((((......)))).).)..))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((.(.....{.(((((.(((...(............)..))).........((......))...)))))...).)))))))).))..........]]].)....))))))))))...)))))))(((((((..)))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((.(.(.(..))..).))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.((((...........))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))((.....).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...))). Crystal structure of antimicrobial peptide Oncocin 10wt bound to the Thermus thermophilus 70S ribosome; 23S Ribosomal RNA 5hcr 2B 120 2.8 RF00001 URS000080DEE8_300852 26809677 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>. .((((((((((....((((((.(....(((((((...(.....)...))))..)))...).)))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of antimicrobial peptide Oncocin 10wt bound to the Thermus thermophilus 70S ribosome; 5S Ribosomal RNA 5hcr 2a 1483 2.8 RF00177,RF01959,RF01960 URS000080DFED_300852 26809677 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccugggccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcggucguaacaagguagcuguaccggaaggugcggcuggau .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<....<<<<<<<....>>>>>>>.>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>>.>>.........<<<<<<<<<....>>>>>>>>>.... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......(((......))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((((((....))))))))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))).))...)..)..(((((((((....)))))))))}... Crystal structure of antimicrobial peptide Oncocin 10wt bound to the Thermus thermophilus 70S ribosome; 16S Ribosomal RNA 5hcr 2x 76 2.8 RF00005 URS000041AF00_562 26809677 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of antimicrobial peptide Oncocin 10wt bound to the Thermus thermophilus 70S ribosome; P-site tRNA 5hd1 1A 2746 2.7 RF02540,RF02541,RF00002 URS00001698E8_300852 26809677 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccagcuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>....<<<<<.....<<....>>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<..>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<......>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((...((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((.(.((((((......)))).)))..))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{..((.().))....)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((..))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((((....)))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..((((.))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of antimicrobial peptide Pyrrhocoricin bound to the Thermus thermophilus 70S ribosome; 23S Ribosomal RNA 5hd1 1B 120 2.7 RF00001 URS000080DEE8_300852 26809677 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>>. .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of antimicrobial peptide Pyrrhocoricin bound to the Thermus thermophilus 70S ribosome; 5S Ribosomal RNA 5hd1 1a 1477 2.7 RF00177,RF01959,RF01960 URS000080DFED_300852 26809677 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccucgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccugggccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcggucguaacaagguagcuguaccggaaggugcggcugga .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<....>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<...<<<<<<......>>>>>.>...>>>>>....<<<<.<<<<<....>>>>>.>>>>...<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<...>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>>.>>...>.....<<<<<<<<<....>>>>>>>>>... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((..)))))))).)))))......(((......((((((((..((...(((((((.(((((....(..............).....)))))....((((..((((....))))..))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((...))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((.(.....).)).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((...(((((((....))))))))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))).))...)..)..(((((((((....)))))))))}.. Crystal structure of antimicrobial peptide Pyrrhocoricin bound to the Thermus thermophilus 70S ribosome; 16S Ribosomal RNA 5hd1 1x 76 2.7 RF00005 URS000041AF00_562 26809677 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of antimicrobial peptide Pyrrhocoricin bound to the Thermus thermophilus 70S ribosome; P-site tRNA 5hd1 2A 2790 2.7 RF02540,RF02541,RF00002 URS00001698E8_300852 26809677 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<.<.<<<<<<......>>>>.>>>..>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<....>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> .((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((((((((..).))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((..))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((.(.((((((......)))).)))..))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((...(............)..))).........((......))...)))))...)))))))))).))..........]]].)....))))))))))...)))))))(((((((..)))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((.(((..))).))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(..((((.........))))....).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))((((.))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...))). Crystal structure of antimicrobial peptide Pyrrhocoricin bound to the Thermus thermophilus 70S ribosome; 23S Ribosomal RNA 5hd1 2B 120 2.7 RF00001 URS000080DEE8_300852 26809677 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>. ...((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).))))))))... Crystal structure of antimicrobial peptide Pyrrhocoricin bound to the Thermus thermophilus 70S ribosome; 5S Ribosomal RNA 5hd1 2a 1483 2.7 RF00177,RF01959,RF01960 URS000080DFED_300852 26809677 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccugggccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcggucguaacaagguagcuguaccggaaggugcggcuggau .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>>>>>>>>..<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>....>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>>.>>...>.....<<<<<<<<<....>>>>>>>>>.... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...(((.....))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......(((......))).....))))....(((((...(....((.(.....).)).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((((((....))))))))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))).))...)..)..(((((((((....)))))))))}... Crystal structure of antimicrobial peptide Pyrrhocoricin bound to the Thermus thermophilus 70S ribosome; 16S Ribosomal RNA 5hd1 2x 76 2.7 RF00005 URS000041AF00_562 26809677 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of antimicrobial peptide Pyrrhocoricin bound to the Thermus thermophilus 70S ribosome; P-site tRNA 5hkv X 2695 3.66 RF02540,RF02541 URS00001450D9_93061 28973455 0003735 0005840 93061 gauuaaguuauuaagggcgcacgguggaugccuuggcacuagaagccaaugaaggacguuacuaacgacgauaugcuuuggggagcuguaaguaagcuuugauccagagauuuccgaauggggaaacccagcaugaguuaugucauguuaucgauauguauacauagcauaucagaaggcacacccggagaacugaaacaucuuaguacccggaggaagagaaagaaaauucgauucccuuaguagcggcgagcgaaacgggaagagcccaaaccaacaagcuugcuuguugggguuguaggacacucuaugaguuacaaaggacgacauuagacgaaucaucuggaaagaugaaucaaagaagguaauaauccuguagucgaaaauguugucucucuugaguggauccugaguacgacggagcacgugaaauuccgucggaaucugggaggaccaucuccuaaggcuaaauacucucuagugaccgauagugaaccaguaccgugagggaaaggugaaaagcaccccggaaggggagugaaauagaaccugaaaccgugugcuuacaaguagucagagcccguuaaugggugauggcgugccuuuuguagaaugaaccggcgaguuacgauuugaugcaagguuaagcaguaaauguggagccguagcgaaagcgagucugaauagggcguuuaguauuuggucguagacccgaaaccaggugaucuacccuuggucagguugaaguucaggcugaauggaggaccgaaccgacuuacguugaaaagugagcggaugaacugaggguagcggagaaauuccaaucgaaccuggagauagcugguucucuccgaaauagcuuuagggcuagccucaagugaugauuauuggagguagagcacuguuuggacgaggguuaccgaauucagacaaacuccgaaugccaauuaauuuaacuugggagucagaacaugggugauaagguccguguucgaaagggaaacagcccagaccaccagcuaaggucccaaaauauauguuaaguggaaaaggauguggcguugcccagacaacuaguagucgagugacacugcgccgaaaauguaccggggcuaaacauauuaccgaagcuguggauugucuggacaaugguaggagagcguucuaagggcguugaagcaugaucguaaggacauguggagcgcuuagaagugagaaugccggugugaguagcgaaagacgggugagaaucccguccaccgauugacuaagguuuccagaggaaggcucguccgcucuggguuagucggguccuaagcugaggccgacaggcguaggcgauggauaacagguugauauuccuguaccaccuauaaucguaucgauggggggacgcaguaggauaggcgaagcgugcgauuggauugcacgucuaagcaguaggcgaguaauccgguacucgggcugagcugugauggggagaagagagucguugauuucacacugccgagaaaagccucuagauagaauaggugcccguaccgcaaaccgacacagguagucaagaugagaauucuaaggugagcgagcgaacucucguuaaggaacucggcaaaaugaccccguaacuucgggagaaggggugcucuuuaggguuaacgcccagaagagccgcagugaauaggcccaagcgacuguuuaucaaaaacacaggucucugcuaaaccguaaggugauguauaggggcugacgccugcccgugcuggaagguuaagaggagugguuagcugcgaagcuacgaaucgaagccccaguaaacggcgcuaagguagcgaaauuccuugucggguaaguuccgacccgcacgaaaggcguaacgauuugggcacugucucaacgagagacucggugaaaucauaguaccugugaagaugcagguuacccgcgacaggacggaaagaccccguggagcuuuacuguagccugauauugaaauucggcuuucuaacccgcaccacuuaucgugugggagacagugucaagcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcucaaagguucccucagaaugguuucauucauagaguguaaaggcauaagggagcuugacugcgagaccuacaagucgagcagggucgaaagacggacuuagugauccggugguuccgcauggaagggccaucgcucaacggauaaaagcuaccccggggauaacaggcuuaucucccccaagaguucacaucgacggggagguuuggcaccucgaugucggcucaucgcauccuggggcuguagucggucccaaggguugggcuguucgcccauuaaagcgguacgcgagcuggguucagaacgucgugagacaguucggucccuauccgucgugggcguaggaaauuugagaggagcuguccuuaguacgagaggaccgggauggacauaccucugguguaccaguugucgugccaacggcauagcuggguagcuauguguggacgggauaagugcugaaagcaucuaagcaugaagccccccucaagaugagauuucccaacuugguuauaagaucccucaaagaugaugagguuaauagguucgagguggaagcauggugacauguggagcugacgaauacuaaucgaucgaagacuuaau ..<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<<<<<<<<.......>>>>>>>.>>.>>....<<<<<......<......>.......>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..(((....<<<<<<<<....>>>>>>>>......<<<<<<<<<..............<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>.>.....>>>>>..>>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<....>>>>..................>>>>>>>>>>>.......<<<<..<<<<......>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<.<<<<<..<<<...<<.......>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>.>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<.>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<...<<<<<<<<<.....<<<...<<<<<<<<...<......>...>>>>>>>>..>>.>.....>>>>.>>>>>..>>>>>>>.>>..<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<.<<<<........<<<...>>>....>>>>.>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<....>>>>>....>>>>>>..<<<<<<<.<<......<<<<<.<<....>>.>>>>>...>>.>>>>>>>........>>>>>><......<<....<<<<<<.......>>>>>><<<<....<<<<<.<<<..<<<<<<...<<.....>>.>>>>>>....((<<<<.<<.<.<<<...<<<....>>>...>>>..>>>...<<<<<........>>>>>))<<<<<<<......<<<...<<<<....<<<<...<<...<....<.<<<...{.{...>>>.>.<....<<<<<.<<<<.............>...>>>..>>>>>.....>..............>....>>...>>>>.........>>>.>.>>>...>>>>>>>>>>>.>>>.....<<......>>>>>>>.<<<<....>.>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<.<<<<....>>>>.>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<..<<.<<<<<<<..<<<...<<...<<<<<..<<.>>...>>>>>...>>...>>>>>>>>..>>>>..........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.(...<<<<<.......)>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<.<<<<<<.<<<<......>>>>....<<.<<<.<<.....>>>>>>>.....>>>>>>.>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.}.}>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>. ..((((((......((((((((((.....(((..((((((((.((((......((((((.[[..[[[)))...].((((((...(((]]..]].)))......))))))...)))....(((....)))(((((((......))))))).((((((((.........)))))).)).))....(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...(((....(((((..........)))))....(.(((((((((.................((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))).........)))))..)))).....(((((((...[.......)))))))....).(((((].[[[[)))))..)))......))..)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((..((((..[...))))..)))).<.(.(........).).((((((..(.(((((((.(((((..(((...(((.....)))...)))...((....))...(((.....)))......))))).)))))))..((.(...((((((.....((((((((((.((((...(((((...)))))...)<)))...(((.(((((.......A))))))))..).))))))))).(.(((....[)))...).]))))))......).))).((((((....(((((....)))))(((((((((...(((((((((.....(((...((((((((..............))))))))..)).).....)))).)))))..))))))).))..((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((.(((((.....{.............))))).)))).))...........]]].)...))))))))))...)))))))((((((..))))))....))))))(.(((((((.((......(((((.((....))])))))...)).)))))))..).....))))))(......((....((((((.......))))))((((....(((...((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]]((((((........((...((((....(((((..((...(..............{...............(((...((....(......)......))....))).....................)....))..)))))(..).....))))..)).....)))))))))).))).....((......))..))).(((.......)))..))))..((((....((((((((.((..(....(.......((((.....(.[..)......))))((((((....((....))....))))))(...).......(((((((((.>.((.........))...(((((((.....(((....))).......))))))).]((((..((.(((((((..(((...((....((((...(.)....))))....))...))))))))..))))..........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).[..(((((.....>].)))))..((((((((.(((.((......((((.((((((..(((((.((.((((((.((((......))))....((..((.((.....)))).)).....)))))).))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((....)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..a.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}..))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))((((...)))....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))...))))))). The crystal structure of the large ribosomal subunit of Staphylococcus aureus in complex with lincomycin; 23s ribosomal RNA 5hkv Y 114 3.66 RF00001 URS00003DF33D_93061 28973455 0003735 0005840 93061 ucuggugacuauagcaaggaggucacaccuguucccaugccgaacacagaaguuaaggucuuuagcgacgaugguagccaacuuacguuccgcuagaguagaacguugccaggc .<<.<..<.....<<<<<<<......<<<<<...............>>>..>>.....>>>>>.>><....<<...<.<............>.>....>>...>..>..>.>>. .(..(..(.....((((.((......((((((...(.....)...))))..)).....)).)).))........................................)..)..). The crystal structure of the large ribosomal subunit of Staphylococcus aureus in complex with lincomycin; 5S ribosomal RNA 5hl7 X 2705 3.55 RF02540,RF02541 URS00001450D9_93061 27958389 0003735 0005840 93061 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.((((((......((((((((((.....(((..((((((((.((((......((((((.[[..[[[)))...].((((((...(((]]..]].)))......))))))...)))....(((....)))(((((((......))))))).(((((((...........))))).)).))....(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...(((....(.(((.((....)).))).)....(..((((((((.................((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))).........)))))..)))......(((((((...[.......)))))))....).(((((].[[[[)))))..)))......))..)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((..((((..[...))))..)))).<.(.(........).).((((((..(.(((((((.(((((..(((...((.......))...)))...((....))...(((.....)))......))))).)))))))..((.(...((((((.....((((((((((.((((...(((((...)))))...)<)))...(((.(((((.......A))))))))..).))))))))).(.(((....[)))...).]))))))......).))).((((((....(((((....)))))(((((((((...(((((((((.....(((...((((((((....(....)....))))))))..)).).....)))).)))))..))))))).))..((((((((((......))))))))))....(((......)))...((((.(((...((([[....(.((((((.....(.....((..((((.(((((.....{.((..(....)..))...))))).)))).))............]].)...))))))))))...)))))))(((((((..)))))))....))))))(.(((((((.((......(((((.((....))])))))...)).)))))))..).....))))))(......((....((((((.......))))))((((....(((...((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]]((((((....((...((((....((((...((...(..............{...............(((...((..(.(......).).....))....))).....................)....))...))))(..).....))))..)).....)))))))))).))).....((......))..))).(((.......)))..))))..((((....((((((((.((..(....(.......(((((....(.[..).....)))))(((((.(...((....))....))))))(...).......(((((((((.>.((.........))...(((((((.....(((....))).......))))))).]((((..((.(((((((..(((...((....((((...(.)....))))....))...))))))))..))))...........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).[..(((((.....>].)))))..((((((((.(((.((......((((.((((((..(((((.((.((((((.(((...(.)...)))....((..(((((.....))))).)).....)))))).))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..a.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}..))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))((((...)))....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))...))))))). The crystal structure of the large ribosomal subunit of Staphylococcus aureus in complex with lefamulin; 23S ribosomal RNA 5hl7 Y 114 3.55 RF00001 URS00003DF33D_93061 27958389 0003735 0005840 93061 ucuggugacuauagcaaggaggucacaccuguucccaugccgaacacagaaguuaaggucuuuagcgacgaugguagccaacuuacguuccgcuagaguagaacguugccaggc .<<.<..<.....<<<<<<<......<<<<<...............>>>..>>.....>>>>>.>><....<....<.<............>.>.....>...>..>..>.>>. .(..(..(.....((((.((......((((((...(.....)...))))..)).....)).)).))........................................)..)..). The crystal structure of the large ribosomal subunit of Staphylococcus aureus in complex with lefamulin; 5S ribosomal RNA 5hp2 B 23 2.983 URS0000A76387_4932 27065196 4932 uuccccacauungacguucaguc ....................... ....................... Human Adenosine Deaminase Acting on dsRNA (ADAR2) bound to dsRNA sequence derived from S. cerevisiae BDF2 gene with AU basepair at reaction site; RNA (5'-R(*UP*UP*CP*CP*CP*CP*AP*CP*AP*UP*UP*(8AZ)P*GP*AP*CP*GP*UP*UP*CP*AP*GP*UP*C)-3') 5hp2 C 23 2.983 URS0000A7632B_4932 27065196 4932 gacugaacgacuaauguggggaa ....................... ....................... Human Adenosine Deaminase Acting on dsRNA (ADAR2) bound to dsRNA sequence derived from S. cerevisiae BDF2 gene with AU basepair at reaction site; RNA (5'-R(*GP*AP*CP*UP*GP*AP*AP*CP*GP*AP*CP*UP*AP*AP*UP*GP*UP*GP*GP*GP*GP*AP*A)-3') 5hp3 B 23 3.091 URS0000A76387_4932 27065196 4932 uuccccacauungacguucaguc ....................... ....................... Human Adenosine Deaminase Acting on dsRNA (ADAR2) bound to dsRNA sequence derived from S. cerevisiae BDF2 gene with AC mismatch at reaction site; RNA (5'-R(*UP*UP*CP*CP*CP*CP*AP*CP*AP*UP*UP*(8AZ)P*GP*AP*CP*GP*UP*UP*CP*AP*GP*UP*C)-3') 5hp3 C 23 3.091 URS0000A763A5_4932 27065196 4932 gacugaacgaccaauguggggaa ....................... ....................... Human Adenosine Deaminase Acting on dsRNA (ADAR2) bound to dsRNA sequence derived from S. cerevisiae BDF2 gene with AC mismatch at reaction site; RNA (5'-R(*GP*AP*CP*UP*GP*AP*AP*CP*GP*AP*CP*CP*AP*AP*UP*GP*UP*GP*GP*GP*GP*AP*A)-3') 5i4l 2 1781 3.1 RF01960,RF01959,RF00177 URS00005F2C2D_559292 27296282 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucau ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[..................<.....<<.<<.......>>.>>......>.........<<<<<..<......>..>>>>>[...((((((......<<<<<<<<<<......>>..............)))))).....]...<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<.<<.<<.<..........>.>>.>>..>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.[[....<<<<<<.<<<<<....<..>....>>>>>.>>>>>>....<<<<<<...........<.......>...........>>>>>>....<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>..........[[...((((((((....>>>>>>>>.))))))))..]].....]]....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>>....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<......<<.<<<<.<<...<.........>....>>.>>>>.>>......>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>....... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[[[[[[[(((....))).....(......).)))))).)...).(.((((..((.......)).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....((..(.((..............)).)...))......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((((.....().....))))).)))))).....(((((...............................)))))....(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(......((.(((....]]]]]]]].))).)).....).....))...(((..((..(...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)..))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...(.((((..(....................)..))).))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>...... Crystal structure of Amicoumacin A bound to the yeast 80S ribosome; 18S ribosomal RNA 5i4l 1 3149 3.1 RF02540,RF02543 URS000061F377_559292 27296282 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>...{.....<<....>>..<<<<<......<<.....>>.....>>>>>..[[[...<.......<<.<<<<<<...>>>>>>.>>.......>.....<<<<<<<.<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]....}.............................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<......<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<......>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>>.>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<<....>>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<.<<<<<<<<<<......>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<...<<.....<<<<....>>>>.....>>.>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<.....>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<<...<<<<<<<<<<}}}.>>>>>..>>>>>..>>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<..<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>..>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((......((((.(....).)))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((....(((((.....)))))..)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((.(((...((.........))...))).....(...(........).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))..............(.....)...........))....))...(((((........)))))]]((((..(((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((((.(...)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.........)))))))...(((((.....((((..((((........))))...........>...((((((....))))))..))))..))))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......(((((..(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).)))..)))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(.(.((..)..).).)..)))))...)))....)))).)))))).))))).. Crystal structure of Amicoumacin A bound to the yeast 80S ribosome; 25S ribosomal RNA 5i4l 3 121 3.1 RF00001 URS000055688D_559292 27296282 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of Amicoumacin A bound to the yeast 80S ribosome; 5S ribosomal RNA 5i4l 4 158 3.1 RF00002 URS00001BF64E_559292 27296282 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of Amicoumacin A bound to the yeast 80S ribosome; 5.8S ribosomal RNA 5i4l 6 1795 3.1 RF01960,RF01959,RF00177 URS00005F2C2D_559292 27296282 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccucuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccgguccgauuuuuucguacuggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[...............<.....<<.<<.......>>.>>......>.........<<<<<..<<....>>..>>>>>[...((((((......<<<<<<<<<<<<..>>>>..............)))))).....]...<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<<<<..............>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.{{....<<<<<<.<<<..<<<<...............>>>>......>>>.>>>>>>....<<<<<<....<<..<<<<.......>>>>..>>....>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[[..((((((((....>>>>>>>>.)))))))).]]].....}}....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<.......<<........>>..........<<<<<......<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<<<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>...>.>>>>>>>.......>>>>>....>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<.<<<..<........>....>>>.>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((...............((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[[[[[[...(....).......(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(.(((.(................).)).).)......(.(.(...........))..).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.((...((((...............)))).......)).))))))....((((((....((..(((((.....)))))..))....))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(((..(.((((((.....]]]]]]].)))))).).))).....))...(((..((.((...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)).))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((........((.(((........))).))......)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...((.((((........................)))).))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>........ Crystal structure of Amicoumacin A bound to the yeast 80S ribosome; 18S ribosomal RNA 5i4l 5 3150 3.1 RF02540,RF02543 URS000061F377_559292 27296282 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacauggcugggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu .........................<<<<<.....<<....>>......>>>>>.....<.....<<....>>..<<<<<......<<.....>>.....>>>>>..<<<..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<.<<<<<..<<<<<<<<<<<<<<.....<<<<......>>>>.(.......<<<......)>>>....>>>>>>>>..>>>>>>......>>>>>>>>>>>........<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>....>.............................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<<...........<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<<..<<<<<<.....>>>>>>>>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<......<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>....>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>>..<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<<.....>.>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..[[[..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<...............>>>>><<.<<<<<<<<<<<..>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<..<<<.....<<<<....>>>>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<..<<<<<<........>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<......>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))......<<<<<<<..<<<<.))))))>>>>>>>>>>>.........>>>>..>>>>>>.......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<<...<<<<<<<<<.]]]..>>>>..>>>>>..>>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..)))))).))...)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((...........(((((((((((((((((((((((.......(((((((......((((((....)))))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((....((.(((((((.....(((....(((..(.((((...(.((((.....)))).).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.......(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((..((((((....((.....))..)))))....[[(((.((...((....(((....)))........(.(..(.(...)..)..).)....))....))...(((((........)))))]]((((.((((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....))))..)))))))).))).))).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((..)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...(......((((....))))......).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(.((............)).)....((((.....((((..((((........))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).).......(((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).))....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.............))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Crystal structure of Amicoumacin A bound to the yeast 80S ribosome; 25S ribosomal RNA 5i4l 7 121 3.1 RF00001 URS000055688D_559292 27296282 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of Amicoumacin A bound to the yeast 80S ribosome; 5S ribosomal RNA 5i4l 8 158 3.1 RF00002 URS00001BF64E_559292 27296282 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of Amicoumacin A bound to the yeast 80S ribosome; 5.8S ribosomal RNA 5ib7 13 1499 2.99 RF00177,RF01959,RF01960 URS0000868551_300852 27174928 0003735 0005840 300852 uuuuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgcguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggacac .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<....>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>.....<......>....>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((((....))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(.(((....))).).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(.....(((.....)))......)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((((..(((((((....))))))).................))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet, near-cognate tRNALys with U-G mismatch in the A-site and antibiotic paromomycin; 16S ribosomal RNA 5ib7 1K 72 2.99 RF00005 URS000042DDAB_83333 27174928 0030533 0006412 83333 gggucguuagcucagugagagcaguugacunuunaucaauugucgcaggnucgaauccugcacgacccacca <<<<.<...<<<<.....>>>>.<<<<<.......>>>>>.....<<<<.......>>>>..>.>>>>.... (((...(..(.(....[...)).((((.........)))).......((..]....))...)...))).... Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet, near-cognate tRNALys with U-G mismatch in the A-site and antibiotic paromomycin; tRNALys 5ib7 2K 77 2.99 RF00005 URS000057545F_83333 27174928 0030533 0006412 83333 cgcggggnggagcagcccgguagcucgucgggnucauaacccgaagnucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet, near-cognate tRNALys with U-G mismatch in the A-site and antibiotic paromomycin; tRNAfMet 5ib7 3K 70 2.99 RF00005 URS000042DDAB_83333 27174928 0030533 0006412 83333 gggucguuagcucagugagcaguugacuuuuaaucaauuggcgcagguucgaauccugcacgacccacca .<<<.....<<<<...>>>><<<<<<.......>>>>>>.....<<<.......>>>.....>>>..... .((........(.....)...(((((.......))))).......(.........).......))..... Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet, near-cognate tRNALys with U-G mismatch in the A-site and antibiotic paromomycin; tRNALys 5ib7 4K 19 2.99 27174928 562 ggagguaaaauggaaaaaa ................... ................... Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet, near-cognate tRNALys with U-G mismatch in the A-site and antibiotic paromomycin; mRNA 5ib7 1H 2860 2.99 RF02540,RF02541,RF00002 URS0000868533_300852 27174928 0003735 0005840 300852 aagaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaacgggggccgaaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuaggggccuccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggggagcucauuuaaagagugcgcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucuu 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.(((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....((.....))....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((.(.((.(.).)))..)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((.(.......(((((...............(........).)))))...).)))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((......))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((.(((((.((.(.........((..(...((......(((.(.(......).).)))...))..............).))).)).))))).)))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(...............(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))). Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet, near-cognate tRNALys with U-G mismatch in the A-site and antibiotic paromomycin; 23S ribosomal RNA 5ib7 16 122 2.99 RF00001 URS00005AB4A7_300852 27174928 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga ..<<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> ..(((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).))))))))))) Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet, near-cognate tRNALys with U-G mismatch in the A-site and antibiotic paromomycin; 5S ribosomal RNA 5ib7 1G 1508 2.99 RF00177,RF01959,RF01960 URS0000868551_300852 27174928 0003735 0005840 300852 uuuuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucac .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<<..>>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<.......<<<<<<<..<<<<<<<....>>>>>>>....<<......>>...>>>>>>>...<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<...<<...<<<.....>>>.>>....>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>....>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>....... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((((((((....))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(.(((....)))..))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(.....((((((.....(.(......).).......((......))...))))))..).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..((...(((.....))).))...))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((..((.(....).))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((..........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}...... Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet, near-cognate tRNALys with U-G mismatch in the A-site and antibiotic paromomycin; 16S ribosomal RNA 5ib7 1L 66 2.99 RF00005 URS000042DDAB_83333 27174928 0030533 0006412 83333 gggucguuagcucauggagcaguugacuuuuaaucaauugcgcagguucgaauccugcacgaccca ...<<<<..<<<<...>>>>.<<<<<.......>>>>>....<<<<.......>>>>.>>>>.... ((..(....(((...[.)))..(((.........)))......(((..]....)))....)..)). Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet, near-cognate tRNALys with U-G mismatch in the A-site and antibiotic paromomycin; tRNALys 5ib7 2L 77 2.99 RF00005 URS000057545F_83333 27174928 0030533 0006412 83333 cgcggggnggagcagcccgguagcucgucgggnucauaacccgaagnucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet, near-cognate tRNALys with U-G mismatch in the A-site and antibiotic paromomycin; tRNAfMet 5ib7 3L 72 2.99 RF00005 URS000042DDAB_83333 27174928 0030533 0006412 83333 gggucguuagcucaggagagcaguugacuuuuaaucaauuggucgcagguucgaauccugcacgacccacca .<<<<<<..<<<<....>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .(((..(..((((....))))...(((.......))).......(.(...........).))..)))..... Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet, near-cognate tRNALys with U-G mismatch in the A-site and antibiotic paromomycin; tRNALys 5ib7 4L 19 2.99 27174928 562 gagguaaaaauggaaaaaa ................... ................... Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet, near-cognate tRNALys with U-G mismatch in the A-site and antibiotic paromomycin; mRNA 5ib7 14 2826 2.99 RF02540,RF02541,RF00002 URS0000868533_300852 27174928 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaacggcgaaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcggacacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccuguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggu .........<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<..>>>>>>.>>....<<<<<.....<......>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<.....<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>.>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>..............>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<....<<<<<......>>>>.>....>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<...............>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<.................<<.......<<<<<<<....>>>>>>.>...>>...................>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<.............>>>>....>>>.>>>>.......>>>>>>>...................<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>..... .........((((((((((.....(((..((((((((((((......((((((.[[..[[[)))...].((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((.(..).)))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((((((((..).))))))))....(.(((((((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))..............)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((...((...(......)....))...)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((((...................))))))).))..........]]].)....))))))))))...)))))))((((((.........))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((.(((((.(((.(.......(......((........((.((((....))))..))....))...............)).))).))))).))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(..................(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...). Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet, near-cognate tRNALys with U-G mismatch in the A-site and antibiotic paromomycin; 23S ribosomal RNA 5ib7 1J 122 2.99 RF00001 URS00005AB4A7_300852 27174928 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga ..<<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> ..(((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).))))))))))) Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet, near-cognate tRNALys with U-G mismatch in the A-site and antibiotic paromomycin; 5S ribosomal RNA 5ib8 13 1500 3.13 RF00177,RF01959,RF01960 URS0000868551_300852 27174928 0003735 0005840 300852 uuguuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgcguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggacac ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<....>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>.................>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(.(((....))).).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....(.((.(.(((....))).).)).)...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(.(((....)))..))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((.(..((((((((((......((........))..........(((((((..(...((((((((..(((((((....))))))).................))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...((((((......(((..((..((((....))))..))....)))......))))))......(....(((((((........)))))))....)..)..).))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet and near-cognate tRNALys with U-G mismatch in the A-site; 16S ribosomal RNA 5ib8 1K 72 3.13 RF00005 URS000042DDAB_83333 27174928 0030533 0006412 83333 gggucguuagcucagngagagcaguugacunuunaucaauugucgcaggnucgaauccugcacgacccacca <<<<<....<<<<.....>>>>.<<<<<.......>>>>>.....<<<<.......>>>>...>>>>>.... (((...(..((((...[.)))).((((.........))))......(((..]....)))..)...))).... Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet and near-cognate tRNALys with U-G mismatch in the A-site; tRNALys 5ib8 2K 77 3.13 RF00005 URS000057545F_83333 27174928 0030533 0006412 83333 cgcggggnggagcagcccgguagcucgucgggnucauaacccgaagnucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet and near-cognate tRNALys with U-G mismatch in the A-site; tRNAfMet 5ib8 3K 70 3.13 RF00005 URS000042DDAB_83333 27174928 0030533 0006412 83333 gggucguuagcucagugagcaguugacuuuuaaucaauuggcgcagguucgaauccugcacgacccacca <<<<.....<<<<...>>>><<<<<<.......>>>>>>.....<<<.......>>>.....>>>>.... .((......(((.....)))..((((.......))))........((.......)).......))..... Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet and near-cognate tRNALys with U-G mismatch in the A-site; tRNALys 5ib8 4K 20 3.13 27174928 562 ggagguaaaaauggaaaaaa .................... .................... Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet and near-cognate tRNALys with U-G mismatch in the A-site; mRNA 5ib8 1H 2831 3.13 RF02540,RF02541,RF00002 URS0000868533_300852 27174928 0003735 0005840 300852 aagaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaacgggggccgaaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuaggggccuccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaaguggaaaggauguggcgccgcgaagacagccagggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucuu <<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.....>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....<<.....>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<...>>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<..........<<..<<<<<<<<<........<<<..>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<.<<<<<<<<<...........<<......<<......<<<<<<<<....>>>>>>>>...>>................>>..>>>>>>>>>.>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<<<<<<<<<..<<.......>>>..>>>>>>>..>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>................<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>> .(((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((......(...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)..)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....((.....))....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((.(.((.(.).)))..)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(....((..((((((((((.......(((..)))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(((((((...(((......(((((.(((....))))))))...)))..))))).)).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((......))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........((..(...((......(((((.(......).)))))...))..............).))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(...............(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))). Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet and near-cognate tRNALys with U-G mismatch in the A-site; 23S ribosomal RNA 5ib8 16 122 3.13 RF00001 URS00005AB4A7_300852 27174928 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga ..<<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> ..(((((((((((....((((((((....(.(((((...(.....)...))))..).)...)))))).))(((.......((.(((((....))))).)).......))).))))))))))) Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet and near-cognate tRNALys with U-G mismatch in the A-site; 5S ribosomal RNA 5ib8 1G 1509 3.13 RF00177,RF01959,RF01960 URS0000868551_300852 27174928 0003735 0005840 300852 uuguuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucac ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<<..>>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<....<<<......>>>.......>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<.......<<<<<<<..<<<<<<<....>>>>>>>....<<......>>...>>>>>>>...<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<...<<<.....>>>>......>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>....>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>....... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((((((((....))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(.....((((((.....(.((....)).).......((......))...))))))..).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.((((.(...(....(((.....)))..)....).)))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((..((.(....).))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((..........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}...... Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet and near-cognate tRNALys with U-G mismatch in the A-site; 16S ribosomal RNA 5ib8 1L 66 3.13 RF00005 URS000042DDAB_300852 27174928 0030533 0006412 300852 gggucguuagcucauggagcaguugacuuuuaaucaauugcgcaggnucgaauccugcacgaccca ...<<<<..<<<<...>>>>.<<<<<.......>>>>>....<<<<.......>>>>.>>>>.... .(..(....(((...[.))).(((((.......))))).....(((..]....)))....)..).. Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet and near-cognate tRNALys with U-G mismatch in the A-site; tRNALys 5ib8 2L 77 3.13 RF00005 URS000057545F_83333 27174928 0030533 0006412 83333 cgcggggnggagcagcccgguagcucgucgggnucauaacccgaagnucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet and near-cognate tRNALys with U-G mismatch in the A-site; tRNAfMet 5ib8 3L 72 3.13 RF00005 URS000042DDAB_83333 27174928 0030533 0006412 83333 gggucguuagcucaggagagcaguugacuuuuaaucaauuggucgcagguucgaauccugcacgacccacca .<<<<<<..<<<<....>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .(((.((..((((....))))...(((.......))).......(((...........))))).)))..... Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet and near-cognate tRNALys with U-G mismatch in the A-site; tRNALys 5ib8 4L 19 3.13 27174928 562 gagguaaaaauggaaaaaa ................... ................... Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet and near-cognate tRNALys with U-G mismatch in the A-site; mRNA 5ib8 14 2825 3.13 RF02540,RF02541,RF00002 URS0000868533_300852 27174928 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaacggcgaaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcggacauggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccuguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggu .........<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<..>>>>>>.>>....<<<<<.....<......>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<.....<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>.>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>..............>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<.....<<<<......>>>>......>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<..............>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<.........<<......<<.......<<<<<<<....>>>>>>.>...>>...............>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<..<<<<<<<...<<.......>>...>>>>>>>...>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<.............>>>>....>>>.>>>>.......>>>>>>>...................<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>..... .........((((((((((.....(((..((((((((((((......((((((.[[..[[[)))...].((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((.(..).)))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((((((((..).))))))))....(.(((((((((..........(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..))))).....)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))..............)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((...((.(((......)))..))...)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((................)))))))).))..........]]].)....))))))))))...)))))))((((((.........))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((.(((((.(((.(.......((......(........((.((((....))))..))....)...............))).))).))))).))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(..................(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))...). Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet and near-cognate tRNALys with U-G mismatch in the A-site; 23S ribosomal RNA 5ib8 1J 122 3.13 RF00001 URS00005AB4A7_300852 27174928 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga ..<<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> ...((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).)))))))))). Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet and near-cognate tRNALys with U-G mismatch in the A-site; 5S ribosomal RNA 5ibb 13 1496 2.96 RF00177,RF01959,RF01960 URS0000868551_300852 27174928 0003735 0005840 300852 uuuuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggacacc .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<..>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>.................>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<...<<<..<<<.....>>>>>>....>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>....... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(..(...).).)))))......(((......((((((((..((...(((((.(.(((((....(((((......))))).....)))))....(.((.(.(((....))).).)).)...(.((...)).).).)))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((((..(((((((....))))))).................))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}...... Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet and cognate tRNAVal in the A-site; 16S ribosomal RNA 5ibb 1K 72 2.96 RF00005 URS00003179F7_83333 27174928 0030533 0006412 83333 gggugauuagcucagngagagcaccucccunacnaggaggggucggcggnucgaucccgucaucacccacca <<<<<....<<<<.....>>>>.<<<<<.......>>>>>.....<<<<.......>>>>...>>>>>.... (((((.(..((.(.....).)).(((((.......))))).......((.......))...).))))).... Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet and cognate tRNAVal in the A-site; tRNAVal 5ibb 2K 77 2.96 RF00005 URS000057545F_83333 27174928 0030533 0006412 83333 cgcggggnggagcagcccgguagcucgucgggnucauaacccgaagnucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet and cognate tRNAVal in the A-site; tRNAfMet 5ibb 3K 70 2.96 RF00005 URS000009F4BF_83333 27174928 0030533 0006412 83333 gggugauuagcucagcgagcaccucccuuacaaggagggggcggcgguucgaucccgucaucacccacca <<<<.<....<<<...>>>..<<<<<.......>>>>>......<<<.......>>>...>.>>>>.... .((..(....(((...)))..(((((.......)))))......................)..))..... Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet and cognate tRNAVal in the A-site; tRNAVal 5ibb 4K 21 2.96 27174928 562 ggagguaaaaaugguaaaaaa ..................... ..................... Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet and cognate tRNAVal in the A-site; mRNA 5ibb 1H 2841 2.96 RF02540,RF02541,RF00002 URS0000868533_300852 27174928 0003735 0005840 300852 aagaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaacgggggccgaaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuaggggccuccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucuu <<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.....>>>>>>.>>....<<<<<.....<......>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....<<.....>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<.....>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<......>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<..<<..<<......<<<<<<<<....>>>>>>>>...>>.............>>.>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<<..<<.......>>>..>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...................<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>> .(((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....((.....))....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((.(.((.(.).)))..)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((.(.......(((((....)))))...).)))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((......))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((.((((((((.(.........((..(...((......(((((((.(...))))))))...))..............).))).)))))))).)))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....((((((..((..]]]]..)).)))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(..................(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))). Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet and cognate tRNAVal in the A-site; 23S ribosomal RNA 5ibb 16 122 2.96 RF00001 URS00005AB4A7_300852 27174928 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga ..<<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> ..(((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).))))))))))) Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet and cognate tRNAVal in the A-site; 5S ribosomal RNA 5ibb 1G 1506 2.96 RF00177,RF01959,RF01960 URS0000868551_300852 27174928 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucac .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<<..>>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>....<<<<.<<<<<....>>>>>.>>>>...<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<.......<<<<<<<..<<<<<<<....>>>>>>>....<<......>>...>>>>>>>..<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>....... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((())))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((.(....).)))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(.....((((((...((((((....)))))).....(((....)))...))))))..).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(....(((.....)))..)...))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}...... Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet and cognate tRNAVal in the A-site; 16S ribosomal RNA 5ibb 1L 69 2.96 RF00005 URS000009F4BF_300852 27174928 0030533 0006412 300852 gggugauuagcucauggagcaccucccuuacaaggaggggcggcggnucgaucccgucaucacccacca <<.<<<<..<<<<...>>>>.<<<<<.......>>>>>....<<<<.......>>>>.>>>>.>>.... ((..(....(((.....))).(((((.......))))).....(((.......)))....)..)).... Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet and cognate tRNAVal in the A-site; tRNAVal 5ibb 2L 76 2.96 RF00005 URS000057545F_83333 27174928 0030533 0006412 83333 cgcggggnggagcagcccgguagcucgucgggnucauaacccgaagncgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......)))))....(((((..]....)))))))))))..... Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet and cognate tRNAVal in the A-site; tRNAfMet 5ibb 3L 71 2.96 RF00005 URS000009F4BF_83333 27174928 0030533 0006412 83333 gggugauuagcucagagagcaccucccuuacaaggagggggucggcgguucgaucccgucaucacccacca <<<<<<<..<<<<...>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... ((((.((..((((...)))).(((((.......)))).)....(...............))).)))).... Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet and cognate tRNAVal in the A-site; tRNAVal 5ibb 4L 19 2.96 27174928 562 gagguaaaaaugguaaaaa ................... ................... Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet and cognate tRNAVal in the A-site; mRNA 5ibb 14 2810 2.96 RF02540,RF02541,RF00002 URS0000868533_300852 27174928 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaacggcgaaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuacaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcggacaggaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccuguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucuugacc .........<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<..>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<.....<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>.>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>..............>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<.......>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<..........>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<.........<<.....<<<.......<<<<<<<<..>>>>>>.>>...>>>..............>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<.........>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>............ .........((((((((((.....(((..((((((((((((......((((((.[[..[[[)))...].((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((......)))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((((((((..).))))))))....(.(((((((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))..............)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((.......)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((............)))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.......((.....((........((.((((....))))..))....))..............))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(..................(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)........ Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet and cognate tRNAVal in the A-site; 23S ribosomal RNA 5ibb 1J 122 2.96 RF00001 URS00005AB4A7_300852 27174928 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga ..<<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> ...((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).)))))))))). Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet and cognate tRNAVal in the A-site; 5S ribosomal RNA 5imq 4 77 3.8 RF00005 URS000041AF00_1412515 27137929 0030533 0006412 1412515 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(.(((..]....))).)))))))..... Structure of ribosome bound to cofactor at 3.8 angstrom resolution; P- site tRNA 5imq 5 76 3.8 RF00005 URS00005AA258_1412515 27137929 0030533 0006412 1412515 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<....<<<........>>>..<<<<<<.....>>>>>>.....<<<<.........>>>>.>>>>>>.... (((((....((((........)))).((((.........))))......((((.......))))...))))).... Structure of ribosome bound to cofactor at 3.8 angstrom resolution; E site tRNA 5imq A 1515 3.8 RF00177,RF01959,RF01960 URS000080E226_300852 27137929 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucaccuccuuu ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<......<<<.<<<..<<<..<<..<<.<<<...........>>>.>>..>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>....<<<<.<<<<<....>>>>>.>>>>...<<<.....>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>...>.>>>>>>..<<<<.......<<<....>>>......>>>>.....<<<<........<<<<.....>>>>..........>>>>.......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<.....>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<..........<<<<...<<<<<<....>>>>>>....<.<......>.>..>>>>.....<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<.......<<<.....>>>......>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>..........<.<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>.......<<...<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>....>>.........<<<<<<<<<....>>>>>>>>>.............. ....((((..[.[[[..)))).(((..(((((..((((((((.....(((.(((..(((...(...(.(((...........))).)...).)))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((.......)).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((.(.........)))))).((((....))))...)))))).......(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....)))).....((((...(....(((.......))).....)....)))).......((((([[[...(((((.....((.]]])).......))))))))))..))))).)))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..((((((.((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..)).)).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((...........))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(....(.(((((..(((.(((....))).))).(.(((......))).)))))).).).((.(((...(((((..(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(....(((.....)))..)...))))))).....((((......))))........)))).....)...)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(.....(.((((........)))).).....)..)..))))).....(((((((..........)))))))......))...)))))))))).))..(.(..((....(((.(((..((((((.((((((...(.((((.....((....))..)))).)..)))))).))))))..)).)))).....))...)..)...((((((((....)))))))).}............. Structure of ribosome bound to cofactor at 3.8 angstrom resolution; 16S ribosomal RNA 5imq D 2889 3.8 RF02540,RF02541,RF00002 URS0000A7635D_300852 27137929 0003735 0005840 300852 ggucaagaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaugcggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgaggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucuugacc ..<<<<........<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<......>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<............<<<....<<..<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>....>>....>>.>.......>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<...<.....<......>.....>.....<<....>>...<<......>>.......>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>....>>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<.........................>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<((......<<<<<<<..........<<..<<<<<<<...........<<<...<...<.............>...>........................>>>.......>>>>>>>.>>...........))......>>>>>>>.>>>...>>>>>>><<.<<<<.......>>>>.>>....>>>>>><.<<<<<...<<<......<<<<<.<......>.>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<..<<<<<<<...<<.....>>.>>>>>>>...((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<.....<<<.....<<<<..<<<..<<<<<.<<<<.<<...[[[...>>>>>>......<<<..<<.<<<<<<<<.<.......>>>>>>>>....>.>>.>>>......<......<<....>>.......>>>>>>...>>>...>>>>.........>>>.........>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<<........<.....<<<<<...............>>>>><<<<<<<.<<........>>..>>>>>>>............<<<<<<<<<..<<<<.......>>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>.>>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.<<......<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<.<<<<<<<<<.............<<<.<..<<<......<<<<<<<<....>>>>>>>>...>>>.............>>>>....>>>>>>>>>.>>>>...<<<<......>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<..<<<<<<<...<<.......>>...>>>>>>>...>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]].>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<.........>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>......>>>>.. ..((((........((((((((((.....(((..(((((((((((.......((((((.[...[[.))).....((((((...(((]]...].)))......))))))...)))....(((....)))((((((((....))))))))..(((........)))...)...((((((.....(......)......)))))..)........((....))...(((((.....(.......)....)))))...(((....((((((((.....)))))))).......(((((((.....((...((((((..(((.(((...(((((......)))))[[(...).(((.....]])))...)))..).))..))).)))..)).))))).))......((((((((.........))))))))......((((((.[[[))))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).......((.(.((((((....)))))).).))...(.(........).).((((((....(((((((((((((..(.....((.......)).....)...((....))....(......)........)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))....))))...(((..((((........)))).)))..).)))))))))...(((.....)))......))))))......).))..((((((....(((((....))))).((((((((.(...(.((.((((...(((...(((.((((.........................)))).)))..)).)...)))).)).)...).))))))).)...(((((((.((......)).))))))).....(((......)))...((((.(((...(((.[....(.(((((((..........((..((((..(.............((......(.............)..........(....(......)..).)).........)..)))).))...........].......)))))))))))...)))))))(((((((.......)))))))....))))))(.(((((....((......(((((.(......).)))))...))...)))))..).....)))))).......((.....((((((.......))))))((((....((((..(....((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((.....(((.....((((..(((..(((((.((((.((...{{....))))))..(...((.......(((((((.(.......))))))))..........))....).(.(.....(.....)....)..))))))...)))...))))(..).....)).)........)))))))))))))))...).....((......)).)))).(((((....)))))..))))..((((....((((((((.((...............(((((....(.[..).....)))))((.(...(.(........)..)...).))(...).......(((((((((...((((.....))))...(((((((.....(((....))).......))))))).]((((.((...(((((((..(((...((...(((((....)))))...))...))))))))..)).)).(((...........))).........((..........(((((.......)))))..)..)....))))...)).))))))).....)).)))))))).))))))...........(((((........)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((.((((.............(((....(((......((((((((....))))))))...)))..............)))....)))).)))))))))...(.((.......)))....))))).)))..)))))..(((.......)))((((((...........))))))([((....((((((.(.(((((.........)))))...).((][.[[[))....))))))....((((..(((...{..)))..)))).(((....))).))]]].].....((.((((.((...]]]..)))))).)).....)}......))))..))))))......(((((...((((((...((.......))...))))))....))).).)......((((.((((((..((.((((((......))))))...)).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(.(((.......(....)......))).).(((((...((((...((((((.((((.}}.)))).)...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))..((.........))....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))......)))).. Structure of ribosome bound to cofactor at 3.8 angstrom resolution; 23S ribosomal RNA 5imq E 123 3.8 RF00001 URS00001170B4_300852 27137929 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcgggggau ..<<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<...<.<.<<<<<<<<....>>>>>>>>...>.>.>>>.>>>>>>>>>>>. ..(((((((((((....((((((((...(.((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).))))))))))). Structure of ribosome bound to cofactor at 3.8 angstrom resolution; 5S ribosomal RNA 5imr A 1515 5.7 RF00177,RF01959,RF01960 URS000080E226_300852 27137929 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucaccuccuuu ....<<<<..[.(((..>>>>.<<<<...<<...<<<<<<<......<<<.<<<...<<..<<..<<<<.<<<<.....>>>>.>>>>..>>>>.......<<.......<<<<<<<...<<...<<<<<<<.<<<<<...<<<<<<......>>>>>.>...>>>>>....<<<<.<<<<<....>>>>>.>>>>...<<<<...>>>>.>>>>>>>..>>.>>>>>>><<<....<<<...<<<<<<<.......>>>>>>>.>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>...>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>...>>..>>>>..........<<<(......<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<.....<<<<<<<.<...<<......>>......>.>>>>>>>...........<<....>>..>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<.<<.........>>.>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<...)>>.....>>>>>>.>>.><<<......<<<<....>>>>....>>>...))).]<<<<<.<<<<<<<.....<<<<<..<<<<<<<<........<<........>>..........<<<<.<<.......<<<<.<<...<<<<<......>>>>>..<.<<<<....>>>>.>>>.>>>>..<<<.<<<...<<<<<.<.....<<<<<<<<<....>>>...<<<......>>>...>>>>>>.....<<<<.<<<<<<<..<<...<<<.....>>>.>>...>>>>>>>.......<<<....>>>..........>>>>.....>...>>>...>>.>>>>>>...>>.>>>>......>>>>>>>>.....<<<<<<<.....<<<..<<..<<<......>>>..>>....>>>.....>>>>>>>......<......<<<<<........>>>>>......>.....>>>>>......<<<<<<..........>>>>>>............>>>>>>>>>>.>>.......<<.<.<<<<.<<<....<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>....>>.>>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>.............. ....(((...[.[[....))).((((.(.(((..(((((((.(....(((......(((..((.(((((((...(...)...))))))).)))))......(((.......(((((((..((...(((((((.(((((....((((((....)))))).....)))))....(((....(((....)))....)))...(((.....))).)))))))..))))))))).(((....(((...(((((((.......))))))).)))......)))....(.((((....))))....)..))).(((((.(.........)))))).((((....))))......))).).....(.(((...(((.(....).)).)))))..).))))))..((((......((((....)))).....))))....(((((...(.....(((.....)))......)....)))))......((((([[[...((((......((.]]]))........)))))))))..))).)))))...........(......(.(((....((..(((((((.(((((((.((......((..((.....))..))....)).)))))..)))))))))..(((((((((...((((((.(...(.((.((....((........)).......)).)).)...).......((....))..))))))..))))).)))..).))....)))....((((((....(......(.........)......).))))))......{...((((((..((((((((((...))))))))))...((....)).....))))))).)..(((......((((....))))....)))....]].](((((..((((((.((..(((((...(((((((........((........))..........((...((..(......((((....((.(((....))).))..(....(....)....).))))...).(..(((....(((((.(.....((((((((....)))...(((......)))...))))).......(((.((((((....(...(((.....))))......)))))).......(((....)))..........)))......).).)))...)..))).)....))...))......)))))))......(((((.......(((..((...(((....)))...))....))).......))))).............((.((........)).))............))))).....(((((((..........)))))))......))...)))))).))).))..(.(.......(.((...(..(.(((((((((((.....((((....(((....))).))))....))))))))))).)..)...)).).........)..)..(((((((((....)))))))))}............. Structure of ribosome bound to cofactor at 5.7 angstrom resolution; 16S ribosomal RNA 5imr D 2889 5.7 RF02540,RF02541,RF00002 URS0000A7635D_300852 27137929 0003735 0005840 300852 ggucaagaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaugcggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgaggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucuugacc .<<<<<........<<<<<<<<<<<.....((..((<<<<<<((<.......<<<<<<.....((.>>>.....<<<<<<<..<<.))......>>.....>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<<.<<....>>.>>>..>...<<<<<<.....<......>......>>>>>.>....................<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<............<<<<<.<<<..<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>....>>>>..>>>>.......>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>.......<<<<..<<<<>>>>...>>>......)).>>>>>>.))...............<<....>>....)).........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<....<..................>.....<<....>>...<<......>>........>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>....>>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<.<<<<.........................>>>>.>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<((......<<<<<<<..........<<..<<<<<<<<.........<.....<<....<...........>....>>..........................>.....>>>>>>>>.>>...........))......>>>>>>>.>>>...>>>>>>><<..<<.........>>..>>....>>>>>><<.<<<<...<<.......<<<<<.<......>.>>>>>....>>..>>>>..>>.....>>>>>>.......<......<<<<<<.......>>>>>><<<<....<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<................>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<.....<<......<<<<<.<<<..<<<<<.<<<<.<<...(((...>>>>>><.....<<<..<....<<<<<..<.......>.>>>>>........>.>>>.....><....<<........>>.....>>>>>>...>>>..>>>>>...........>>........>>>>>>>>>>>>>>>..>>.....<<......>>.>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<...<..............<<<<<....<<..>>.....>>>>><<<<<<.<.<........>.>..>>>>>>............<<<<<<<<<..<<.<........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>..<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>>.<<<<<.......>>>>>.........<...........<<<<<<.....>>>>>>.....>....>>>>...>>.>>>>>>>.....>..>>>>>>>>.>>>>.>...........<<<<<........>>>>>...<<<<<<<.<<<.((......<<<<.((.<<<..<<<<<.<<<.<.<<<.<<<<<<<<<<<<.<<<...........<<<....<<<.......<<<<<<<....>>>>>>>....>>>..............>>>..>>>.>>>>>>>>>>>>...<<<<......>>>>....>>>.>.>>>..>>>>>...<<<.....>>>.<<<<<<...........>>>>>>..<<...<<<<<<<....<<<<<.......>>>>>......<<...((.>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>.)).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>...))>>>>........<<...<<<<<<<<..<<.......>>>..>>>>>>>....>>.........<<<<<.<.<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>...>...>>>>.>....<<<<<<<....>>>.>>>>....))..>>>>>>>>>>.....<<<<<<<...<<<<..<<<<<<<.....<....>....>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>...>>>>.>..>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>....<.......>......<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>......>>>>>. ..(.(.........(((.((((((......((..(.((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))(((((((......)))))))....(........)....))...((((((.....(...[..)......))))).)....................(((((.....(..]....)....)))))...(((....((((.(((.....))).))))......(...((((.....(.....(((((....(.((....(((((......)))))[[(...).(((.....]])))....))..)......)))))....).))))....).....((((((((.........)))))))).......((((..[[..))))...)))......)).))))))..)...............((....))....))..........(((....)))....................)))))).))).......(((.(((((((....))))))).)))..................((((((....((((.((((((((...(......(.....)......)....((....))..(.(.......).).....)))))))).))))..((.....(((((......((((((((.(.(.((...((((((......))))))....)).)...((...((((........))))..))..)..))))))))...(((.....))).......)))))........))..((((.(....(((((....)))))(((((((((.....(((((.((....(((...(((.((((.........................)))).)))..)).)....)).))))).....))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...(((.[....(.(((.(.(..........((..((.....((..........((..................................................).).....).)....)).))...........].......).).)))))))...)))))))((((((((.....)))))))).....)))))(...(((....((......(((((.(......).)))))...))...)))....).....))))))...............(((((.......))))).((((....((((.......((((((...((.....)).))))))......((((.((...(((...(((....)))...)))...))...(((((........)))))..((((((((((......(((.....((((..(((..(((((..(((.((....{....))))).(.(...((..(....((((((..((.....)).)))))).........)))....))(.....(........)......))))))...)))...))))..........))).........))))))))))))))..........(.......).)))).((((......))))..))))..((((....((((((((.(................(((((....(....).....)))))((((((.(.((.......)).).))))))(...).......(((((((((.....((.....).).....((((((......((....))........))))))...((((..((...((((((..(((...((...(((((....)))))...))...))))))))..).))............................((..........(((((.......)))))..)..)....))))...)).)))))))......).)))))))).)))).............(((((........)))))..((((((((.((...(......((((.((.(((..(((.(.(((.(((((.(((((((((.((..(............(((.....((.......(...(.(....).)...)....))...............)))..)...).))))))))))...(((........)))....))))).)))..).)))...((......[)).((((((..........]))))))(..(...(((((((.(.((((((.......))))))...).((.[.[[.))....))))))).....(...(((...{..)))...)...((......)).)..]].].....(((((((.((....]]..))))))))).....)}......)))...))))))........((....((((((...((.......))...)))))).....))..........((((.(((.((..(((((((((......))))))..))).(((((.....))))).....)).))..)...))).).....((.((((....))).).))....)....))))))))))[...((((((.(..((((..(.(((...................))).).((((....((((...(((((((.(((.}..))).))...)))))...))))..))))...(((....(((((...........)))))....))).))))..]...).))))))....(........).....((((.((((.......)))).....((((((((.(((....(((((....)))))...)))..))))).)))...)))).......).).. Structure of ribosome bound to cofactor at 5.7 angstrom resolution; 23S ribosomal RNA 5imr E 123 5.7 RF00001 URS00001170B4_300852 27137929 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcgggggau ...<<<<<<<<<.....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>><<<...<...<<<<<<<<....>>>>>>>>.....>.>>>..>>>>>>>>>.. ...((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))((........((.((.((....)).)).))........)).)))))))))).. Structure of ribosome bound to cofactor at 5.7 angstrom resolution; 5S ribosomal RNA 5imr 4 77 5.7 RF00005 URS000041AF00_1412515 27137929 0030533 0006412 1412515 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....((.((..]....)).))))))))..... Structure of ribosome bound to cofactor at 5.7 angstrom resolution; P site- tRNA 5imr 5 76 5.7 RF00005 URS00005AA258_1412515 27137929 0030533 0006412 1412515 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<...<<<..........>>>.<<<<<<.....>>>>>>.......<<<.......>>>..>.>>>>>.... ((.(((...((((........)))).((((.(.....).))))......((((.......))))..))).)).... Structure of ribosome bound to cofactor at 5.7 angstrom resolution; E site- tRNA 5iqr 1 2904 3.0 RF02540,RF02541 URS0000B21DEA_83333 27279228 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaacccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccuu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>>.>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<..<<....>>..>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<<.<<....>>..>>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<..<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<..<<.......<<<<<<<<....>>>>>>>>....>>............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>...>>>>..<<<<.....>>>><<<<<<...........>>>>>>.(<<...<<<<<<<...<<<<<<.......>>>>>>.....<<)..(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>.. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).((((.((((.........))))).))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((.(((.....))).).))...)))).)))..)).).....))))))).))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((.(......).))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..(((((.((((((...{{{.).))))).((..((((...(((.((((((((.((.....))))))))))...)))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((....(((....])))....)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.(.((.(..........(((...(((.......(((((((....)))))))....))).............))).).)).).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).).....((.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..))....(.(((((....))).)).)....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))).. Structure of RelA bound to the 70S ribosome; LSU rRNA 5iqr 2 1533 3.0 RF00177,RF01959,RF01960 URS000080E246_83333 27279228 0003735 0005840 83333 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<......>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>..<<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>>.<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .......((((..[.[[[[.)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((........))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..........)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((.......((.]]])).........))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......(((.((.....)).)))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))..]]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((.(.((..(((..((....))..))).............)).)..))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..((.......))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Structure of RelA bound to the 70S ribosome; SSU rRNA 5iqr 3 118 3.0 RF00001 URS0000366A67_83333 27279228 0003735 0005840 83333 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))). Structure of RelA bound to the 70S ribosome; 5S rRNA 5iqr 4 76 3.0 RF00005 URS00005AA258_83333 27279228 0030533 0006412 83333 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca .<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((....((((........)))).((((.........)))).....(((((.......)))))..))))..... Structure of RelA bound to the 70S ribosome; E-site tRNA(Phe) 5iqr 5 77 3.0 RF00005 URS0000A76396_83333 27279228 0030533 0006412 83333 cgcggggungagcagccuggnagcucgucgggnucauaacccgaagaucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(.(((..]....))).)))))))..... Structure of RelA bound to the 70S ribosome; P-site fMet-tRNA(fMet) 5iqr 6 76 3.0 RF00005 URS000024E9F9_83333 27279228 0030533 0006412 83333 gcccgganagcucagnuggnagagcaggggauugaanauccccgunnccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>><<<<<<<.....>>>>>>.>...<<<<<.......>>>>>>>>>>>>.... (((((((..((((........))))((((((.......))))).)...(((((.......)))))))))))).... Structure of RelA bound to the 70S ribosome; A/T tRNA(Phe) 5iqr 7 10 3.0 27279228 32630 aaaauguucu .......... .......... Structure of RelA bound to the 70S ribosome; mRNA 5it7 5 3270 3.6 RF02540,RF02543 URS0000A76339_28985 27159451 0003735 0005840 28985 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........................<<<<<<.....<......>......>>>>>.>...<.....<<....>>..<<<<<......<<.....>>.....>>>>>..<<<..<........<<.<<<<<<...>>>>>>.>>........>....<<<<<<<.<<<<.<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>.....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>....>.............................<<....>>...............<<<<....>>>>..................................<<<<<<<<<<<<.......<<<<<<<.<<<<<<<<<<<<<<<.....<<<<.<<<<......<<<<<<<....>>>>>>>.......>>>>.>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<..<<<<<.....>>>>>..>>>...<<....>>.......<<<<<..<<<<....>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<.<<<<.....<<<....<<<..<.<<<<..<<<<<<<.....>>>>>>>>>>>.>..>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>......>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<......<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>....>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>>..<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<......>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<...<.<<<....>>>.......<<<<<<...<<<<.<<<<.<<<<<<<<<<<<<..[[[..>>>>>><...<<<<<....<<<<<.....<<<.....>>>.....>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>.>.>>.>>>>.>>>>.........>>>>>>.....>....>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<...............>>>>><<.<<<<<<<<<<..........<<<..<<<<....<<<<..>>>>....>>>>..>>>...........................>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>.<.<<..<<<..<<<<<<....<<<....<<<<<....>>>>.>...>>>.>>>>..>>>>>.<<<<<.......>>>>>.........<...........<<<<<.......>>>>>.....>.....>>.>..>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<....<<<<.<.....<<<<..........<<<<<..<<....>>............>>>>>.>>>>.....>>>.>>......<<<<<.....<<<<....<<<......>>>.................<<<<<.....>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<[..(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).]....<<<<<<<..<<<<.))))))>>>>>>>>>>>.........>>>>..>>>>>>.......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<..<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<<]]].>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<<<..<<<......>>>..>>>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<.<..<<<<<......>>>>>..>>>>>...>>>....>>>>.>>>>>..>>>>>.. 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Structure of the Kluyveromyces lactis 80S ribosome in complex with the cricket paralysis virus IRES and eEF2; 25S ribosomal RNA 5it7 7 121 3.6 RF00001 URS000055688D_28985 27159451 0003735 0005840 28985 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Structure of the Kluyveromyces lactis 80S ribosome in complex with the cricket paralysis virus IRES and eEF2; 5S ribosomal RNA 5it7 8 157 3.6 RF00002 URS0000A7639C_28985 27159451 0003735 0005840 28985 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaauugcgauauguauugugaauugcagauuuucgugaaucaucaaaucuuugaacgcacauugcgcccucugguauuccagggggcaugccuguuugagcgucauu .........................................<<<<<<<((....>>>>.....<..<<......))..............>>...>...>>>....<<.....>><<<<<<<<<....>>>>>>>>>.................... .........................................((((((.[[.....))).....(..(((.....]]............).))...)...)))....((.....))(((((((((....))))))))).................... Structure of the Kluyveromyces lactis 80S ribosome in complex with the cricket paralysis virus IRES and eEF2; 5.8S ribosomal RNA 5it7 2 1780 3.6 RF01960,RF01959,RF00177 URS0000A76325_28985 27159451 0003735 0005840 28985 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...<<<<<.{.[[[[>>>>><<<<.<<<<<<...<.<...<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<..<...<<....<<<<...............<<.....<<.<<.......>>.>>......>>........<<<<<..<<....>>..>>>>><..<<.<<<<......(((((((.<<<....>>>..............>>>>>>.....>...<<<<..<<<.....>>>.>>>>..>.>>>...>>.>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<<..>>>.>...>>>>>>.........<<<....<<<.....>>>..>>>..>....>.>.....<<<<<<<<<<.<......>.>>>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>>.........<<<[[.....<.<<...<<<.<<....<<<<<<<<<<<.....<..>.....>>>>>>>>>>>....<<<<<<......<<..<<.......>>..>>......>>>>>>...<<<<<.<<.......<<...<.......>..<<<....>>>....>>......>>.>>..>>>.........<<<..<<<<<<<<.....))))))).>>>>>>>>.>>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>......<<<....>>>..>>>>..>>.>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..]]>>...>>.....>>>.>>>.<<<......<<<......>>>....>>>..]]]].}<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<......<<<<<.....<..<<.<............>.>>.>....>>>>>...<..<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<<<<<<<<....>>>>>>.>>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>.>.......>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<<.<<<<....>>>>.>>>....>>.......>>>>>>>......<....<<<<<<..........>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<..<...<<<<<<..<...................>...>>>>>>...>..>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[[.))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((...(....(((............{...((.....((.(((.....))).))......))........(((((..((....))..)))))(.(((.((((......[[[.[[[.(((....))).....(......).)))))).)...).(}((((..((((..).))).)))))..).))...)).)..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....((.((((((..((....))..))))))..))......(((.(...........)).)).........(((.([[....(.((((.....((..]])).......)))))).)))..))))))))))..{......((({{...(.(.((...(((.((....(((((((((.(......()......)).))))))))....((((((.........(.(.......).).........))))))...(((((.((.......((..((.......)).(((....)))....))......)).))..)))........((((..(.((.(((.....]]].]]].))).)).).)))..)..))....((..((.((...((((...(...(((((.........................)))).)..)........((....))..).)))..)).))...))...)))...)).)....(((((.........((((.........))))......)))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))..]]]].](((((.(((((((..((..(((((..(((.((((((.......(........).........(.(((((.(....((((.........((.(............)).).......))))....(.(((...(.((((((....(((.(.(((....)))..(.((......)))....).)))....(((((.((..((((..((((((((((((....)))))).))))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))......).))))))..)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..((((..(...(((((...(....................)...)))))...)..))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>........ Structure of the Kluyveromyces lactis 80S ribosome in complex with the cricket paralysis virus IRES and eEF2; 18S ribosomal RNA 5it7 4 190 3.6 RF00458 URS0000A7638F_12136 27159451 0043022 12136 aaaaaugugaucuugcuuguaaauacaauuuugagagguuaauaaauuacaaguagugcuauuuuuguauuuagguuagcuauuuagcuuuacguuccaggaugccuaguggcagccccacaauauccaggaagcccucucuacgguuuuucagauuagguagucgaaaaaccuaagaaauuuaccugcu <<<<<.........<<<<<<<<...........((((.........>>>>>>>>.......>>>>>......<<<<.<<<<....>>>>.......[[.(((.>>>>.<<<<.....>>>>....))).]].....)))).......<<<<<.<<<.((((.>>>>>>>>.............))))... (((((........(((((((((.(.........[[.........).)))))))))......)))))......[[[..((((....))))..........(((..]]].((((.....))))....)))..........]].......(.((...((..[[[.))..)).).............]]].... Structure of the Kluyveromyces lactis 80S ribosome in complex with the cricket paralysis virus IRES and eEF2; cricket paralysis virus IRES 5it8 AA 1534 3.12 RF00177,RF01959,RF01960 URS000081169C_83333 27382179 0003735 0005840 83333 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<.<<<<....>>>>.>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((.(..(........)..)..)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((...(....).)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(..(.((((((((.......)))))))).)...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((.((....)).)))....(......)..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... High-resolution structure of the Escherichia coli ribosome; 16S rRNA 5it8 BA 1533 3.12 RF00177,RF01959,RF01960 URS000081169C_83333 27382179 0003735 0005840 83333 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<.<<<......>>>.>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((.((.(........).))..)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((...(....).)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(..(.((((((((.......)))))))).)...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((.((....)).)))....(......)..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... High-resolution structure of the Escherichia coli ribosome; 16S rRNA 5it8 CB 118 3.12 RF00001 URS0000049E57_83333 27382179 0003735 0005840 83333 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))). High-resolution structure of the Escherichia coli ribosome; 5S rRNA 5it8 CA 2898 3.12 RF02540,RF02541 URS00004B0F34_83333 27382179 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccuu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<.>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<..<......>..>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<..<<....>>...>>>>>..>....>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>.. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((.((...))..))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(...(........).).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((..(......)..)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((((.(..........(((...(((......((((((((....))))))))...))).............))).).)))).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).).....((.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..))....(.(((((....))).)).)....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))).. High-resolution structure of the Escherichia coli ribosome; 23S rRNA 5it8 DB 120 3.12 RF00001 URS0000049E57_83333 27382179 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). High-resolution structure of the Escherichia coli ribosome; 5S rRNA 5it8 DA 2897 3.12 RF02540,RF02541 URS000080E25C_83333 27382179 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<...>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<......>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<<<<<...<<<<....<<<<<<<<....>>>>>>>>.>>>>.............>>>.>>..>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((.((...))..))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(...(........).).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((((......))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((..(((.(.........((.((...((......((((((((....))))))))...)).............)).))).)))..)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).).....((.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..))....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). High-resolution structure of the Escherichia coli ribosome; 23S rRNA 5it9 2 1780 3.8 RF01960,RF01959,RF00177 URS0000A76382_28985 27159451 0003735 0005840 28985 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacauggauaucugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacuccuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaacuggagggcaagucuggugccagcagccgcgguaauuccagcuccaguagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggucugguuguccggucgguuuuucaaccggaucuuuccuucuggcuaaccuguacuccuugugggugcaggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcgaaagcucgaauauauuagcauggaauaauggaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuucuuaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaggguugcuggcacuugccgguugacucuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgaguacaaccuuggccgagaggucuggguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggauuugcuuagagaagggggcaacuccaucucagagcgaagaaucuggucaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.{.[[[[>>>>><<<<.<<<<<<...<.<...<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<..<<..<.....<<<<...............<<.....<<.<<.......>>.>>......>>........<<<<<..<<....>>..>>>>>...<.<<<<<......(((((((.<<<....>>>..............>>>>>>.........<<<<..<<<.....>>>.>>>>..>.>>>....>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<<..>>>.>...>>>>>>.........<<<....<<<.....>>>..>>>..>....>.>.....<<<<<<<<<<.<......>.>>>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>>.........<<<[[.....<.<<...<<<.<<....<<<<<<<<<<<.....<..>.....>>>>>>>>>>>....<<<<<<......<<..<<.......>>..>>......>>>>>>...<<<<<.<<.......<<...<.......>..<<<....>>>....>>......>>.>>..>>>.........<<<..<<<<<<<<.....))))))).>>>>>>>>.>>>.....>>....<<<<<<.<<...<<<<...<<.<<<<<<.<...<<<......>>>......>.>>>>>>.>>.......<<<....>>>..>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<.......<<<<.<.....>.>>>>....>>>>>>>..........<<<.<<..<...<<<<<<<<.<<<........>>>>>>>>>>>..>.....<<..]]>>...>>.....>>>.>>>.<<<......<<<......>>>....>>>..]]]].}<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.........<<.....<..<<.<............>.>>.>....>>......<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<<<<<<<<....>>>>>>.>>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>.......>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<<.<<<<....>>>>.>>>....>>.......>>>>>>>......<.<..<<<<<<..........>>>>>>>...>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<..<...<<<<<<..<...................>...>>>>>>...>..>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[[.))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((...(...(.((............(...((.....((.(.(.....).).))......))........(((((..((....))..)))))(..((.((((......[[[.[[[.(((....))).....(......).)))))).....)..)((((..((((..).))).))))....)))...)).)..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....((.((((((..((....))..))))))..))......(((.(...........)).)).........(((.([[....(.((((.....((..]])).......)))))).)))..))))))))))..{......((({{...(.(.((...(((.((....(((((((((.(......()......)).))))))))....((((((.........(.(.......).).........))))))...(((((.((.......((..((.......)).(((....)))....))......)).))..))).........(((..(.((.(((.....]]].]]].))).)).).))).....))....((..((.((...((((...((.((((((.........................)))))).))........((....))..).)))..)).))...))...)))...)).)....(((((.........((((.........))))......)))))......<...(((.((.(......((((((.(((........)))))))))......)...((..}}))...))...}.))))))).(((......((((....))))....)))..]]]].](((((.(((((((..((..(((((..(((.((((((.......(........)...........(((((.(.................((.(............)).)..............((.(((...(.((((((....(((.(.(((....)))..(.((......)))....).)))....(((((.((..(((...((((((((((((....)))))).))))))..).)).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....((((((.(.......)).)))))......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..((((..(...(((((...(....................)...)))))...)..))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>........ Structure of the yeast Kluyveromyces lactis small ribosomal subunit in complex with the cricket paralysis virus IRES.; 18S ribosomal RNA 5it9 i 192 3.8 RF00458 URS0000A7632F_12136 27159451 0043022 12136 aaaaaugugaucuugcuuguaaauacaauuuugagagguuaauaaauuacaaguagugcuauuuuuguauuuagguuagcuauuuagcuuuacguuccaggaugccuaguggcagccccacaauauccaggaagcccucucugcggcuuuucagauuagguagucgaaaaaccuaagaaauuuaccugcuac <<<<<.........<<<<<<<<..........(((((.........>>>>>>>>.......>>>>>.........(.<<<<....>>>>.....<<<<.<<<.)....<<<<.....>>>>....>>>.>>>>...)))))......((.((..((.<<<<<)).)))).............>>>>>..... (((((..........(((((((..........[[[[[.........)))))))........)))))........[[.((((....)))).....((((.((..].]..((((.....)))).....)).))))...]]]]]......[[[[[.....(((((...]]]]]............)))))..... Structure of the yeast Kluyveromyces lactis small ribosomal subunit in complex with the cricket paralysis virus IRES.; Cricket paralysis virus IRES RNA 5j02 A 414 3.493 RF02001,RF01998 URS0000B21DD4_182710 27934709 0000373 182710 gugugcccggcaugggugcagucuauagggugagagucccgaacugugaaggcagaaguaacaguuagccuaacgcaacugcgccguggcgacauggcgugggaaggaagcggacggcaaaccuucggucugaggaacacgaacuucauaugaggcuagguaucaauggaugaguuugcauaacaaaacaaaguccuuucugccaaaguugguacagaguaaaugaagcagauugaugaagggaaagacugcauucuuacccggggaggucuggaaacagaagucagcagaagucauaguacccuguucgcaggggaaggacggaacaaguauggcguucgcgccuaagcuugaaccgccguauaccgaacgguacguacggugguguggcaggggcgcgcccccuaugccgau .....<<<<<...<<<<<<<<<<<...<<<.......>>>..<<<<<...(((((((...>>>>>..<<<...<<<..<<<<<<<<<<....>>>>>>>>>>.......>>>...>>>...<<<<<<<<<<<...........<<<<<......<<<..<<<<<<<<<<<<..<<<<........>>>>...>>>>.)))))))...>>>>>>>>..>>>...>>>>>>>>>>...>>>>>>...>>>>>>>>>>>....>>>>>....<<<<....>>>>...........<<<......<<<<<....>>>>>....>>>....<<<<<..<<<<<..>>>>>...>>>>>.<<<<<<<<<<<<<....>>>..>>>>>>>>>>..<<<<<<<<.<..>>>>>>..>>>... ..[<.((((({..(.(((((((((...(((.......)))..(((((...[[[[[[[...)))))..(((...(((..((((((((((....))))))))))...>}..)))...)))...(((((((((((.(.....)...(((((.....[(((..((((((((((((..((((.]......))))...)))).]]]]]]]...))))))))..)))...))))))))))...))))))...))))))))).)...])))))(...((((....))))...)(......(((.(....(((((....)))))...))))....(((((.(((((....))))..)))))).(((((((((((((....)))..))))))))))..((((((((.(()))))))..)))..) Structure of the lariat form of a chimeric derivative of the Oceanobacillus iheyensis group II intron in the presence of NH4+, MG2+ and an inactive 5' exon.; GROUP II INTRON LARIAT 5j30 RA 2867 3.2 RF02540,RF02541,RF00002 URS00001698E8_300852 27681416 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<.......>>>....>>......................>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<.<<<<<......>>>>>>....>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((..))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((...((((((......)))).))...)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((........((((.((....((.......)).....)).........(........)...))))....)))))))))).))..........]]].)....))))))))))...)))))))(((((((())))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((.(.((((.(......[..(((((..(((........(((..........))).....)))..........].)))))).)))).).)))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))((((.))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Thermus thermophilus 70S termination complex containing E. coli RF1; 23S rRNA 5j30 RB 120 3.2 RF00001 URS00005F2F4B_300852 27681416 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>. .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Thermus thermophilus 70S termination complex containing E. coli RF1; 5S rRNA 5j30 QA 1500 3.2 RF00177,RF01959,RF01960 URS000080DFED_300852 27681416 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<.<......>.>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((..)))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((((((....)))))))...((((....))))...)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.... Thermus thermophilus 70S termination complex containing E. coli RF1; 16S rRNA 5j30 QV 77 3.2 RF00005 URS000041AF00_1355101 27681416 0030533 0006412 1355101 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(.(((..]....))).)))))))..... Thermus thermophilus 70S termination complex containing E. coli RF1; P-site tRNA fMet 5j30 QX 10 3.2 27681416 32630 aaauguaaca .......... .......... Thermus thermophilus 70S termination complex containing E. coli RF1; messenger RNA 5j30 YA 2867 3.2 RF02540,RF02541,RF00002 URS00001698E8_300852 27681416 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<.<.......>.>....>>......................>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<.<<<<<......>>>>>>....>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> 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Thermus thermophilus 70S termination complex containing E. coli RF1; 23S rRNA 5j30 YB 120 3.2 RF00001 URS00005F2F4B_300852 27681416 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Thermus thermophilus 70S termination complex containing E. coli RF1; 5S rRNA 5j30 XA 1504 3.2 RF00177,RF01959,RF01960 URS000080DFED_300852 27681416 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<..<<<<<<<<....>>>>>>>>..>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>.....<......>....>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((..(((((((((..)))))))))..)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((...(((((((....))))))).(...((....))...).)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.... Thermus thermophilus 70S termination complex containing E. coli RF1; 16S rRNA 5j30 XV 77 3.2 RF00005 URS000041AF00_1355101 27681416 0030533 0006412 1355101 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Thermus thermophilus 70S termination complex containing E. coli RF1; P-site tRNA fMet 5j3c RA 2867 3.04 RF02540,RF02541,RF00002 URS00001698E8_300852 27681416 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>....<<<<<.....<......>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..<<<.......>>>...>>>......................>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<.<<<<<......>>>>>>....>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> 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Thermus thermophilus 70S termination complex containing E. coli RF1; 23S rRNA 5j3c RB 120 3.04 RF00001 URS00005F2F4B_300852 27681416 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>. .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Thermus thermophilus 70S termination complex containing E. coli RF1; 5S rRNA 5j3c QA 1500 3.04 RF00177,RF01959,RF01960 URS000080DFED_300852 27681416 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<..........>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((..)))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((((((....)))))))...((((....))))...)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.... Thermus thermophilus 70S termination complex containing E. coli RF1; 16S rRNA 5j3c QV 77 3.04 RF00005 URS000041AF00_1355101 27681416 0030533 0006412 1355101 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Thermus thermophilus 70S termination complex containing E. coli RF1; P-site tRNA fMet 5j3c YA 2867 3.04 RF02540,RF02541,RF00002 URS00001698E8_300852 27681416 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<.........>>....>>......................>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<.<<<<<......>>>>>>....>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((..))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((.(.((((((......)))).)))..)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((((((........(((((.((....((.......)).....)).....(...((......)).).)))))....))))))))).))..........]]].)....))))))))))...)))))))(((((((())))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((.(.((((.(......[..(((((..(((........(((..........))).....)))..........].)))))).)))).).)))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))((((.))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Thermus thermophilus 70S termination complex containing E. coli RF1; 23S rRNA 5j3c YB 120 3.04 RF00001 URS00005F2F4B_300852 27681416 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Thermus thermophilus 70S termination complex containing E. coli RF1; 5S rRNA 5j3c XA 1504 3.04 RF00177,RF01959,RF01960 URS000080DFED_300852 27681416 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<..<<<<<<<<....>>>>>>>>..>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>.....<......>....>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((..(((((((((..)))))))))..)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((...(((((((....))))))).(...((....))...).)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.... Thermus thermophilus 70S termination complex containing E. coli RF1; 16S rRNA 5j3c XV 77 3.04 RF00005 URS000041AF00_1355101 27681416 0030533 0006412 1355101 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Thermus thermophilus 70S termination complex containing E. coli RF1; P-site tRNA fMet 5j3c XX 10 3.04 27681416 32630 aaauguaaca .......... .......... Thermus thermophilus 70S termination complex containing E. coli RF1; messenger RNA 5j4b 1A 2871 2.6 RF02540,RF02541,RF00002 URS00001698E8_300852 27079977 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>....<<<<<.....<<....>>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<....<<<<........>>>..>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..<<......(..>>...>>>.........<<......>>.).>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<.<......>.>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((...((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((.(...((..........)..).)..)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((..((.........))...))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(......[..(((((..(((......(((((..........)))))...)))..........].)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..(((...)))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with cisplatin (co-crystallized) and bound to mRNA and A-, P- and E-site tRNAs at 2.6A resolution; 23S ribosomal RNA 5j4b 1B 120 2.6 RF00001 URS000080DEE8_300852 27079977 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the Thermus thermophilus 70S ribosome in complex with cisplatin (co-crystallized) and bound to mRNA and A-, P- and E-site tRNAs at 2.6A resolution; 5S ribosomal RNA 5j4b 1a 1500 2.6 RF00177,RF01959,RF01960 URS000080DFED_300852 27079977 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>.<..<<......>>.>..>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((..)))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((..((((....))))..))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((...(((.(((....))).)))....(((....)))....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the Thermus thermophilus 70S ribosome in complex with cisplatin (co-crystallized) and bound to mRNA and A-, P- and E-site tRNAs at 2.6A resolution; 16S ribosomal RNA 5j4b 1v 13 2.6 27079977 32630 aaaaauguucuaa ............. ............. Crystal structure of the Thermus thermophilus 70S ribosome in complex with cisplatin (co-crystallized) and bound to mRNA and A-, P- and E-site tRNAs at 2.6A resolution; mRNA 5j4b 1w 74 2.6 RF00005 URS00005AA258_562 27079977 0030533 0006412 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<......>>>><<<<<<<.....>>>>>>.>...<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[..)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with cisplatin (co-crystallized) and bound to mRNA and A-, P- and E-site tRNAs at 2.6A resolution; A-site and E-site tRNAs 5j4b 1x 76 2.6 RF00005 URS000041AF00_562 27079977 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with cisplatin (co-crystallized) and bound to mRNA and A-, P- and E-site tRNAs at 2.6A resolution; P-site tRNA 5j4b 1y 74 2.6 RF00005 URS00005AA258_562 27079977 0030533 0006412 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((......)))).((((.........)))).....(((((.......)))))))))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with cisplatin (co-crystallized) and bound to mRNA and A-, P- and E-site tRNAs at 2.6A resolution; A-site and E-site tRNAs 5j4b 2A 2800 2.6 RF02540,RF02541,RF00002 URS00001698E8_300852 27079977 0003735 0005840 300852 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Crystal structure of the Thermus thermophilus 70S ribosome in complex with cisplatin (co-crystallized) and bound to mRNA and A-, P- and E-site tRNAs at 2.6A resolution; 23S ribosomal RNA 5j4b 2B 120 2.6 RF00001 URS000080DEE8_300852 27079977 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>. ..(((((((((....((((((.(....(((((((...(.....)...))))..)))...).)))).))(((.......((((((((....)))))))).......))).))))))))).. Crystal structure of the Thermus thermophilus 70S ribosome in complex with cisplatin (co-crystallized) and bound to mRNA and A-, P- and E-site tRNAs at 2.6A resolution; 5S ribosomal RNA 5j4b 2a 1503 2.6 RF00177,RF01959,RF01960 URS000080DFED_300852 27079977 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggau .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<.....>>.....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((.(....).)))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...((((((......))))))..................)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}... Crystal structure of the Thermus thermophilus 70S ribosome in complex with cisplatin (co-crystallized) and bound to mRNA and A-, P- and E-site tRNAs at 2.6A resolution; 16S ribosomal RNA 5j4b 2v 13 2.6 27079977 32630 aaaaauguucuaa ............. ............. Crystal structure of the Thermus thermophilus 70S ribosome in complex with cisplatin (co-crystallized) and bound to mRNA and A-, P- and E-site tRNAs at 2.6A resolution; mRNA 5j4b 2w 72 2.6 RF00005 URS00005AA258_562 27079977 0030533 0006412 562 cccgganagcucagggagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<..<<<<.....>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((...[.)))).((((.........))))......((((..]....)))).))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with cisplatin (co-crystallized) and bound to mRNA and A-, P- and E-site tRNAs at 2.6A resolution; A-site and E-site tRNAs 5j4b 2x 76 2.6 RF00005 URS000041AF00_562 27079977 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(.(((..]....))).)))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with cisplatin (co-crystallized) and bound to mRNA and A-, P- and E-site tRNAs at 2.6A resolution; P-site tRNA 5j4b 2y 73 2.6 RF00005 URS00005AA258_562 27079977 0030533 0006412 562 gcccgganagcucagggagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<.....>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[.)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with cisplatin (co-crystallized) and bound to mRNA and A-, P- and E-site tRNAs at 2.6A resolution; A-site and E-site tRNAs 5j4c 1A 2871 2.8 RF02540,RF02541,RF00002 URS00001698E8_300852 27079977 0003735 0005840 300852 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Crystal structure of the Thermus thermophilus 70S ribosome in complex with cisplatin (soaked) and bound to mRNA and A-, P- and E-site tRNAs at 2.8A resolution; 23S ribosomal RNA 5j4c 1B 120 2.8 RF00001 URS000080DEE8_300852 27079977 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the Thermus thermophilus 70S ribosome in complex with cisplatin (soaked) and bound to mRNA and A-, P- and E-site tRNAs at 2.8A resolution; 5S ribosomal RNA 5j4c 1a 1500 2.8 RF00177,RF01959,RF01960 URS000080DFED_300852 27079977 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<......>>....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((((((....))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((..((((....))))..))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((.(((....))).)))....(((....)))....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the Thermus thermophilus 70S ribosome in complex with cisplatin (soaked) and bound to mRNA and A-, P- and E-site tRNAs at 2.8A resolution; 16S ribosomal RNA 5j4c 1v 13 2.8 27079977 32630 aaaaauguucuaa ............. ............. Crystal structure of the Thermus thermophilus 70S ribosome in complex with cisplatin (soaked) and bound to mRNA and A-, P- and E-site tRNAs at 2.8A resolution; mRNA 5j4c 1w 74 2.8 RF00005 URS00005AA258_562 27079977 0030533 0006412 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<......>>>><<<<<<<.....>>>>>>.>...<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[..)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with cisplatin (soaked) and bound to mRNA and A-, P- and E-site tRNAs at 2.8A resolution; A-site and E-site tRNAs 5j4c 1x 76 2.8 RF00005 URS000041AF00_562 27079977 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with cisplatin (soaked) and bound to mRNA and A-, P- and E-site tRNAs at 2.8A resolution; P-site tRNA 5j4c 1y 74 2.8 RF00005 URS00005AA258_562 27079977 0030533 0006412 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((......)))).((((.........)))).....(((((.......)))))))))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with cisplatin (soaked) and bound to mRNA and A-, P- and E-site tRNAs at 2.8A resolution; A-site and E-site tRNAs 5j4c 2A 2800 2.8 RF02540,RF02541,RF00002 URS00001698E8_300852 27079977 0003735 0005840 300852 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Crystal structure of the Thermus thermophilus 70S ribosome in complex with cisplatin (soaked) and bound to mRNA and A-, P- and E-site tRNAs at 2.8A resolution; 23S ribosomal RNA 5j4c 2B 120 2.8 RF00001 URS000080DEE8_300852 27079977 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>. ..(((((((((....((((((.(....(((((((...(.....)...))))..)))...).)))).))(((.......((((((((....)))))))).......))).))))))))).. Crystal structure of the Thermus thermophilus 70S ribosome in complex with cisplatin (soaked) and bound to mRNA and A-, P- and E-site tRNAs at 2.8A resolution; 5S ribosomal RNA 5j4c 2a 1503 2.8 RF00177,RF01959,RF01960 URS000080DFED_300852 27079977 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggau .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<.....>>.....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((.(..).)))))))).)))))......(((......((((((((..((...(((((((.(((((....((((.(....).)))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...((((((......))))))..................)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}... Crystal structure of the Thermus thermophilus 70S ribosome in complex with cisplatin (soaked) and bound to mRNA and A-, P- and E-site tRNAs at 2.8A resolution; 16S ribosomal RNA 5j4c 2v 13 2.8 27079977 32630 aaaaauguucuaa ............. ............. Crystal structure of the Thermus thermophilus 70S ribosome in complex with cisplatin (soaked) and bound to mRNA and A-, P- and E-site tRNAs at 2.8A resolution; mRNA 5j4c 2w 72 2.8 RF00005 URS00005AA258_562 27079977 0030533 0006412 562 cccgganagcucagggagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<..<<<<.....>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((...[.)))).((((.........))))......((((..]....)))).))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with cisplatin (soaked) and bound to mRNA and A-, P- and E-site tRNAs at 2.8A resolution; A-site and E-site tRNAs 5j4c 2x 76 2.8 RF00005 URS000041AF00_562 27079977 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with cisplatin (soaked) and bound to mRNA and A-, P- and E-site tRNAs at 2.8A resolution; P-site tRNA 5j4c 2y 73 2.8 RF00005 URS00005AA258_562 27079977 0030533 0006412 562 gcccgganagcucagggagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<.....>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....)))).((((.........)))).....(((((.......)))))))))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with cisplatin (soaked) and bound to mRNA and A-, P- and E-site tRNAs at 2.8A resolution; A-site and E-site tRNAs 5j4d A 1507 3.1 RF00177,RF01959,RF01960 URS0000A763A8_262724 27107638 0003735 0005840 262724 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgaggaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<.......>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<......>>>..>>>>>>>>.<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((((((((.......))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...(((.....))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((....(....(((.(....).)))......(........)....)...)))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.... E. coli release factor 1 bound to the 70S ribosome in response to a pseudouridylated stop codon; 16S ribosomal RNA 5j4d B 2880 3.1 RF02540,RF02541,RF00002 URS0000A76375_262724 27107638 0003735 0005840 262724 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgccuuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgucuaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcucaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaaaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagcuccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagacgacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<........>>>>>.>>....<<<<<.....<<....>>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>..<....<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<.<<..<.....................>.......................>>.>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>....>>>>>>>>>..>>><...<<<<<..>>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>>.<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<...<........<<<<<<<....>>>>>>>.....>.............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((........))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((.(.((((.(......).)).)))..))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((((((........((..(...............................(..............).)..))....))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....)))))))))....)))))))))..)))(....(((....)))......))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(......[..(((((....(.......(((.(.(....).).)))....)............].)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(...((.....))......(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) E. coli release factor 1 bound to the 70S ribosome in response to a pseudouridylated stop codon; 25S ribosomal RNA 5j4d C 120 3.1 RF00001 URS000080DFF2_262724 27107638 0003735 0005840 262724 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>. .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). E. coli release factor 1 bound to the 70S ribosome in response to a pseudouridylated stop codon; 5S ribosomal RNA 5j4d D 77 3.1 RF00005 URS000041AF00_83333 27107638 0030533 0006412 83333 cgcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((.(((..(((.......[...))).(((((.......))))).....(.(((..]....))).)))).))..... E. coli release factor 1 bound to the 70S ribosome in response to a pseudouridylated stop codon; tRNA 5j4d HA 11 3.1 27107638 32630 aaaauguaaaa ........... ........... E. coli release factor 1 bound to the 70S ribosome in response to a pseudouridylated stop codon; mRNA 5j4d IA 77 3.1 RF00005 URS000041AF00_83333 27107638 0030533 0006412 83333 cgcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... E. coli release factor 1 bound to the 70S ribosome in response to a pseudouridylated stop codon; tRNA 5j4d FB 1507 3.1 RF00177,RF01959,RF01960 URS0000A763A8_262724 27107638 0003735 0005840 262724 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgaggaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<.......>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<......>>>..>>>>>>>>.<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((((((((.......))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...(((.....))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((....(....(((.(....).)))......(........)....)...)))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... E. coli release factor 1 bound to the 70S ribosome in response to a pseudouridylated stop codon; 16S ribosomal RNA 5j4d GB 2880 3.1 RF02540,RF02541,RF00002 URS0000A76375_262724 27107638 0003735 0005840 262724 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgccuuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgucuaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcucaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaaaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagcuccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagacgacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<........>>>>>.>>....<<<<<.....<<....>>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>..<....<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<.<<..<.....................>.......................>>.>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>....>>>>>>>>>..>>><...<<<<<..>>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>>.<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<...<........<<<<<<<....>>>>>>>.....>.............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((........))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((.(.((((.(......).)).)))..))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((((((.........(..(...............................(..............).)..).....))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....)))))))))....)))))))))..)))(....(((....)))......))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(......[..(((((....(.......(((.(.(....).).)))....)............].)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(...((.....))......(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) E. coli release factor 1 bound to the 70S ribosome in response to a pseudouridylated stop codon; 25S ribosomal RNA 5j4d HB 120 3.1 RF00001 URS000080DFF2_262724 27107638 0003735 0005840 262724 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>. .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). E. coli release factor 1 bound to the 70S ribosome in response to a pseudouridylated stop codon; 5S ribosomal RNA 5j4d IB 77 3.1 RF00005 URS000041AF00_83333 27107638 0030533 0006412 83333 cgcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((.(((..(((.......[...))).(((((.......))))).....(.(((..]....))).)))).))..... E. coli release factor 1 bound to the 70S ribosome in response to a pseudouridylated stop codon; tRNA 5j4d MC 11 3.1 27107638 32630 aaaauguaaaa ........... ........... E. coli release factor 1 bound to the 70S ribosome in response to a pseudouridylated stop codon; mRNA 5j4d NC 77 3.1 RF00005 URS000041AF00_83333 27107638 0030533 0006412 83333 cgcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... E. coli release factor 1 bound to the 70S ribosome in response to a pseudouridylated stop codon; tRNA 5j5b AA 1534 2.8 RF00177,RF01959,RF01960 URS000081169C_83333 27382179 0003735 0005840 83333 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<.<<<<....>>>>.>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((.(..(........)..)..)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((...(....).)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(..(.((((((((.......)))))))).)...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..((((.((....)).))))...(......)..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Structure of the WT E coli ribosome bound to tetracycline; 16S rRNA 5j5b BA 1533 2.8 RF00177,RF01959,RF01960 URS000081169C_83333 27382179 0003735 0005840 83333 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<.<<<......>>>.>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<<..>>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((.(..(........)..)..)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..........)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(..(.((((((((.......)))))))).)...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..((((.((....)).))))...(......)..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Structure of the WT E coli ribosome bound to tetracycline; 16S rRNA 5j5b CB 118 2.8 RF00001 URS0000049E57_83333 27382179 0003735 0005840 83333 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))). Structure of the WT E coli ribosome bound to tetracycline; 5S rRNA 5j5b CA 2898 2.8 RF02540,RF02541 URS00004B0F34_83333 27382179 0003735 0005840 83333 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<<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<.>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<..<......>..>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<<.<<....>>..>>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>.. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((((...))).))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(...(........).).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((.(......).))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((((.(..........(((.....(......((((((((....))))))))...)...............))).).)))).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).).....((.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..))....(.(((((....))).)).)....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))).. Structure of the WT E coli ribosome bound to tetracycline; 23S rRNA 5j5b DB 120 2.8 RF00001 URS0000049E57_83333 27382179 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Structure of the WT E coli ribosome bound to tetracycline; 5S rRNA 5j5b DA 2897 2.8 RF02540,RF02541 URS00004B0F34_83333 27382179 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<...>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<......>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<..<<....>>...>>>>>..>....>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<<<<<...<<<<....<<<<<<<<....>>>>>>>>.>>>>.............>>>.>>..>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((((...))).))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(...(........).).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((((......))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((..(((.(..........(.((...((......((((((((....))))))))...)).............)).).).)))..)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).).....((.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..))....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Structure of the WT E coli ribosome bound to tetracycline; 23S rRNA 5j7l AA 1534 3.0 RF00177,RF01959,RF01960 URS0000A7637F_83333 27382179 0003735 0005840 83333 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcggcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<.<<<<....>>>>.>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<...<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>.>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((.((.(........).))..)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((...(....).)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(..(.((((((((.......)))))))).)...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..((((.((....)).))))...(......)..))))).))).((.((....((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...))..))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Structure of the 70S E coli ribosome with the U1052G mutation in the 16S rRNA bound to tetracycline; 16S rRNA 5j7l BA 1533 3.0 RF00177,RF01959,RF01960 URS0000A7637F_83333 27382179 0003735 0005840 83333 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcggcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<.<<<......>>>.>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<...<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>.>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((.((.(........).))..)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((...(....).)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(..(.((((((((.......)))))))).)...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..((((.((....)).))))...(......)..))))).))).((.((....((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...))..))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Structure of the 70S E coli ribosome with the U1052G mutation in the 16S rRNA bound to tetracycline; 16S rRNA 5j7l CB 118 3.0 RF00001 URS0000049E57_83333 27382179 0003735 0005840 83333 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))). Structure of the 70S E coli ribosome with the U1052G mutation in the 16S rRNA bound to tetracycline; 5S rRNA 5j7l CA 2898 3.0 RF02540,RF02541 URS00004B0F34_83333 27382179 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccuu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<.>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<..<......>..>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<<.<<....>>..>>>>>>..>....>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>.. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((((...))).))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(...(........).).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((.(......).))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((((.(..........(((.....(......((((((((....))))))))...)...............))).).)))).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).).....((.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..))....(..((((....))).)..)....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))).. Structure of the 70S E coli ribosome with the U1052G mutation in the 16S rRNA bound to tetracycline; 23S rRNA 5j7l DB 120 3.0 RF00001 URS0000049E57_83333 27382179 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Structure of the 70S E coli ribosome with the U1052G mutation in the 16S rRNA bound to tetracycline; 5S rRNA 5j7l DA 2897 3.0 RF02540,RF02541 URS00004B0F34_83333 27382179 0003735 0005840 83333 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<<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<.>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<......>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<<.<<....>>..>>>>>>..>....>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<<<<<..<<<<<....<<<<<<<<....>>>>>>>>.>>>>>............>>>.>>..>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((((...))).))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(...(........).).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((((......))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((..(((.(..........(.((...((......((((((((....))))))))...)).............)).).).)))..)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).).....((.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..))....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Structure of the 70S E coli ribosome with the U1052G mutation in the 16S rRNA bound to tetracycline; 23S rRNA 5j88 AA 1534 3.32 RF00177,RF01959,RF01960 URS0000A76355_562 27382179 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcagucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<.<<<......>>.>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<........<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<<..<<<.....>>>>>.....>>>>>>.....<<<<<.....>>>>>........>>>>..........>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((.(..(.(....).)..)..)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..........)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(..(.((((((((.......)))))))).)...)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((....((..((....))..))...............)))).))).((.(((...((((...(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....)....))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Structure of the E coli 70S ribosome with the U1060A mutation in 16S rRNA; 16S rRNA 5j88 BA 1533 3.32 RF00177,RF01959,RF01960 URS0000A76355_562 27382179 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcagucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<......>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<........<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<<..<<<.....>>>>>.....>>>>>>.....<<<<<.....>>>>>........>>>>..........>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((.((.(........).))..)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..........)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(..(.((((((((.......)))))))).)...)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((....((..((....))..))...............)))).))).((.(((...((((.(......(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).......)..))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Structure of the E coli 70S ribosome with the U1060A mutation in 16S rRNA; 16S rRNA 5j88 CB 118 3.32 RF00001 URS0000049E57_562 27382179 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))). Structure of the E coli 70S ribosome with the U1060A mutation in 16S rRNA; 5S rRNA 5j88 CA 2898 3.32 RF02540,RF02541 URS00004B0F34_562 27382179 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccuu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<.>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<.<<....>>.>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<<.<<....>>..>>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>.. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((.((...))..))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(...(........).).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((..(......)..)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((((.(..........(((....((......((((((((....))))))))...))..............))).).)))).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).).....((.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..))....(.(((((....))).)).)....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))).. Structure of the E coli 70S ribosome with the U1060A mutation in 16S rRNA; 23S rRNA 5j88 DB 120 3.32 RF00001 URS0000049E57_562 27382179 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Structure of the E coli 70S ribosome with the U1060A mutation in 16S rRNA; 5S rRNA 5j88 DA 2897 3.32 RF02540,RF02541 URS00004B0F34_562 27382179 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<...>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<......>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<<.<<....>>..>>>>>>..>....>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<.<<<...<<<<....<<<<<<<<....>>>>>>>>.>>>>.............>>>..>..>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((.((...))..))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(...(........).).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((((......))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((..(((.(.........((((....((......((((((((....))))))))...))..............))))).)))..)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).).....((.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..))....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Structure of the E coli 70S ribosome with the U1060A mutation in 16S rRNA; 23S rRNA 5j8a AA 1534 3.1 RF00177,RF01959,RF01960 URS0000A7637F_562 27382179 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcggcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<.<<<<....>>>>.>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<...<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>.>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((.((.(........).))..)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((...(....).)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(..(.((((((((.......)))))))).)...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..((((.((....)).))))...(......)..))))).))).((.((....((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...))..))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Structure of the E coli 70S ribosome with the U1052G mutation in 16S rRNA bound to tigecycline; 16S rRNA 5j8a BA 1533 3.1 RF00177,RF01959,RF01960 URS0000A7637F_562 27382179 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcggcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<.<<<......>>>.>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<...<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>.>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((.((.(........).))..)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((...(....).)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(..(.((((((((.......)))))))).)...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..((((.((....)).))))...(......)..))))).))).((.((....((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...))..))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Structure of the E coli 70S ribosome with the U1052G mutation in 16S rRNA bound to tigecycline; 16S rRNA 5j8a CB 118 3.1 RF00001 URS0000049E57_562 27382179 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))). Structure of the E coli 70S ribosome with the U1052G mutation in 16S rRNA bound to tigecycline; 5S rRNA 5j8a CA 2898 3.1 RF02540,RF02541 URS00004B0F34_562 27382179 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccuu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<.>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<..<......>..>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<..<<....>>...>>>>>..>....>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>.. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((((...))).))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(...(........).).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((.(......).))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((((.(..........(((.....(......((((((((....))))))))...)...............))).).)))).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).).....((.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..))....(.(((((....))).)).)....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))).. Structure of the E coli 70S ribosome with the U1052G mutation in 16S rRNA bound to tigecycline; 23S rRNA 5j8a DB 120 3.1 RF00001 URS0000049E57_562 27382179 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Structure of the E coli 70S ribosome with the U1052G mutation in 16S rRNA bound to tigecycline; 5S rRNA 5j8a DA 2897 3.1 RF02540,RF02541 URS00004B0F34_562 27382179 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<...>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<......>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<<<<<...<<<<....<<<<<<<<....>>>>>>>>.>>>>.............>>>.>>..>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((((...))).))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(...(........).).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((((......))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((..(((.(..........(.((...((......((((((((....))))))))...)).............)).).).)))..)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).).....((.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..))....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Structure of the E coli 70S ribosome with the U1052G mutation in 16S rRNA bound to tigecycline; 23S rRNA 5j8b A 2874 2.6 RF02540,RF02541,RF00002 URS00001698E8_300852 27092003 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<...>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<<.>.>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<.<<........>.>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<..<...<<<<.......>>>>...>..........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<...........>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<.<<<<<<....>>>>>>.>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((((((((..).))))))))....(.(((((((((..(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((...))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((....))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((...((...(......)....))...))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{..((.(...(..(((.........)))..).......(...((......)).).).))....)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((..))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((.((...............)).))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((.(.((..((.(......[..(((((..(((.........(((((....)))))......)))..........].)))))).))..)).).)))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(..(((.))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal structure of Elongation Factor 4 (EF-4/LepA) in complex with GDPCP bound to the Thermus thermophilus 70S ribosome; 23S Ribosomal RNA 5j8b B 120 2.6 RF00001 URS000080DEE8_300852 27092003 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>. (((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).))))))))))) Crystal structure of Elongation Factor 4 (EF-4/LepA) in complex with GDPCP bound to the Thermus thermophilus 70S ribosome; 5S Ribosomal RNA 5j8b a 1498 2.6 RF00177,RF01959,RF01960 URS000080DFED_300852 27092003 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>.....<......>....>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((...(....)...))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((...(((((((....)))))))...(.........)....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...(...(((.....)))).....))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Crystal structure of Elongation Factor 4 (EF-4/LepA) in complex with GDPCP bound to the Thermus thermophilus 70S ribosome; 16S Ribosomal RNA 5j8b v 13 2.6 27092003 300852 aaaaauguucuaa ............. ............. Crystal structure of Elongation Factor 4 (EF-4/LepA) in complex with GDPCP bound to the Thermus thermophilus 70S ribosome; mRNA 5j8b w 74 2.6 RF00005 URS00005AA258_300852 27092003 0030533 0006412 300852 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (.(((((..((((...[..)))).((((.........)))).....(((((..]....)))))))))).).... Crystal structure of Elongation Factor 4 (EF-4/LepA) in complex with GDPCP bound to the Thermus thermophilus 70S ribosome; A-site tRNA 5j8b x 77 2.6 RF00005 URS000041AF00_300852 27092003 0030533 0006412 300852 cgcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of Elongation Factor 4 (EF-4/LepA) in complex with GDPCP bound to the Thermus thermophilus 70S ribosome; P-site tRNA 5j8b y 74 2.6 RF00005 URS00005AA258_300852 27092003 0030533 0006412 300852 gcccgganagcucaggguagagcaggggauugaanauccccguguccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[..)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of Elongation Factor 4 (EF-4/LepA) in complex with GDPCP bound to the Thermus thermophilus 70S ribosome; E-site tRNA 5j91 AA 1534 2.96 RF00177,RF01959,RF01960 URS000081169C_562 27382179 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<.<<<<....>>>>.>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((.(..(........)..)..)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((...(....).)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(..(.((((((((.......)))))))).)...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..((((.((....)).))))...(......)..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Structure of the Wild-type 70S E coli ribosome bound to Tigecycline; 16S rRNA 5j91 BA 1533 2.96 RF00177,RF01959,RF01960 URS000081169C_562 27382179 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<.<<<......>>>.>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<<..>>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((.(..(........)..)..)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..........)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(..(.((((((((.......)))))))).)...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..((((.((....)).))))...(......)..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Structure of the Wild-type 70S E coli ribosome bound to Tigecycline; 16S rRNA 5j91 CB 118 2.96 RF00001 URS0000049E57_562 27382179 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))). Structure of the Wild-type 70S E coli ribosome bound to Tigecycline; 5S rRNA 5j91 CA 2898 2.96 RF02540,RF02541 URS00004B0F34_562 27382179 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccuu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<.>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<..<......>..>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<<.<<....>>..>>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>.. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((((...))).))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(...(........).).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((.(......).))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((((.(..........(((.....(......((((((((....))))))))...)...............))).).)))).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).).....((.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..))....(.(((((....))).)).)....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))).. Structure of the Wild-type 70S E coli ribosome bound to Tigecycline; 23S rRNA 5j91 DB 120 2.96 RF00001 URS0000049E57_562 27382179 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Structure of the Wild-type 70S E coli ribosome bound to Tigecycline; 5S rRNA 5j91 DA 2897 2.96 RF02540,RF02541 URS00004B0F34_83333 27382179 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<...>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<......>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<..<<....>>...>>>>>..>....>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<<<<<...<<<<....<<<<<<<<....>>>>>>>>.>>>>.............>>>.>>..>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((((...))).))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(...(........).).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((((......))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((..(((.(..........(.((...((......((((((((....))))))))...)).............)).).).)))..)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).).....((.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..))....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Structure of the Wild-type 70S E coli ribosome bound to Tigecycline; 23S rRNA 5jaj X 11 1.5 URS0000A76390_32630 27203181 32630 gguacguaccc ........... ........... Structure of chicken LGP2 witha 5'p 10-mer dsRNA and ADP-AlF4-Mg.; RNA (5'-R(P*GP*GP*UP*AP*CP*GP*UP*AP*CP*CP*C)-3') 5jaj Y 10 1.5 URS0000A76349_32630 27203181 32630 gguacguacc .......... .......... Structure of chicken LGP2 witha 5'p 10-mer dsRNA and ADP-AlF4-Mg.; RNA (5'-R(P*GP*GP*UP*AP*CP*GP*UP*AP*CP*C)-3') 5jb2 X 11 2.2 URS0000A76390_32630 27203181 32630 nguacguaccc ........... ........... Crystal structure of chicken LGP2 with 5'ppp 10-mer dsRNA and ADP-AlF4-Mg2+ at 2.2 A resolution.; RNA (5'-R(*GPPP*GP*UP*AP*CP*GP*UP*AP*CP*CP*C)-3') 5jb2 Y 10 2.2 URS0000A76349_32630 27203181 32630 nguacguacc .......... .......... Crystal structure of chicken LGP2 with 5'ppp 10-mer dsRNA and ADP-AlF4-Mg2+ at 2.2 A resolution.; RNA (5'-R(*GPPP*GP*UP*AP*CP*GP*UP*AP*CP*C)-3') 5jb3 2 1495 5.34 RF00177,RF01959,RF01960 URS0000A77851_272844 27819266 0003735 0005840 272844 auuccgguugauccugccggaggccacugcuauggggguccgacuaagccaugcgagucaagggggcgucccuucugggacgccaccggcggacggcucaguaacacgucgguaaccuacccucgggagggggauaaccccgggaaacuggggcuaaucccccauaggccugggguacuggaagguccccaggccgaaagggagccguaaggcccgcccgaggaugcggcggcggccgauuagguaguuggugggguaacggcccaccaagccgaagaucgguacgggccgugagagcgggagcccggagauggacacugagacacggguccaggcccuacggggcgcagcaggcgcgaaaccuccgcaaugcgggaaaccgcgacggggggacccccagugccgugccucuggcacggcuuuuccggaguguaaaaagcuccgggaauaagggcugggcaaggccgguggcagccgccgcgguaauaccggcggcccgagugguggccacuauuauugggccuaaagcggccguagccgggcccguaagucccuggcgaaaucccacggcucaaccguggggcucgcuggggauacugcgggccuugggaccgggagaggccggggguacccccgggguaggggugaaauccuauaaucccggggggaccgccaguggcgaaggcgcccggcuggaacggguccgacggugagcgcggaaggccaggggagcgaaccggauuagauacccggguaguccuggcuguaaaggaugcgggcuaggugucgggcgagcuucgagcucgcccggugccguagggaagccguuaagcccgccgccuggggaguacggccgcaaggcugaaacuuaaaggaauuggcgggggagcacuacaagggguggagcgugcgguuuaauuggauucaacgccgggaaccucaccgggggcgacggcaggaugaaggccaggcugaaggucuugccggacgcgccgagaggaggugcauggccgccgucagcucguaccgugaggcguccacuuaagugugguaacgagcgagacccgcgcccccaguugccagucccucccgcucgggaggaggcacucuggggggacugccggcgauaagccggaggaaggggcgggcgacgguaggucaguaugccccgaaacccccgggcuacacgcgcgcuacaaugggcgggacaaugggacccgaccucgaaaggggaagggaauccccuaaacccgcccucaguucggaucgcgggcugcaacucgcccgcgugaagcuggaaucccuaguacccgcgugucaucaucgcgcggcgaauacgucccugcuccuugcacacaccgcccgucacuccacccgagcggaguccgggugaggccugaucuccuucgggaggucaggucgagcccgggcuccgugaggggggagaagucguaacaagguaaccguaggggaaccuacggcucgaucaccuccu ...<<<<..[.((((.>>>>.<<<<<<<<<....<<<<.<<......<<<.<<<..<<<..<<.<<<<<<<<....>>>>>>>>.>>>>>......<<........<<<<<.<...<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<<<<<.<<<....>>>>>>>>>>>>....<<..<<<....>>>>>.>>>>>>>..>.>.>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<............>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>..>>>>...<<<<<<<<...>>>>>>>>...<<<<<<<.........>>>>>>>.....<<<<<((.....<<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((......<<....<<<.<<<<<<<.<<<<<<<<<.....<<<<<<<<.....>>>>>>>>....>>>>>>>..>>>>>>>>>...<<<<<<.....<<<<<<<<<<.<<<<<<<<<..<<<......>>>.....>>>>>>>>>.>>>.......<<....>>.>>>>>>>....>>>.>>>...>>>....>>....<<<<<<<...<<...<<<<.........>>>>...>>>>>>>>>.........<<<<<<..<<<<<<<<<<<<<<.....>>>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<...<<<<........<<<.<<<<.....>>>>.>>>......>>>>...<<.<<<..<<<<<<<<<....<<<<<<.<<....>>...<<<<......>>>>..>>>>>>....<<<<<.<<<<<<<...<...<.<<<<<<<..>>>>>>>>>.....>>>>>>>.....<<<<<.....>>>>>........>>>>>....>>>.>>>...>>>>>>>>....>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>.....<<<<<<.........>>>>>>.......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<..<<<<<<<<<<<<<..>>>>>>>>>>>>>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.......<<<<<<<....>>>>>>>.............. ...((((..[.[[[..)))).((((((.((....((((.(((.....(((.(((..(((..(..((((((((....))))))))..))))......(((.......(((((.(...(...(((((((.(((((....((((((....)))))).....)))))...(((((((((.((......)))))))))))....((..(((....))))).)))))))..).).))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).))..))))...((((.(((...))).))))....((((((.........))))))......((((.[[.....(((((.....((..]])).......))))).))))..)).))))))..........((([[...(..((....(((.(((((((.((((((..(......(((((((.....))))))).....)..))))..)))))))))..(((((((.....((((((.(((.((((((((...((........))......)))))))).))).......((....))..))))))....))).)))..))))....)).....((((((...((...((((.........))))...))))))))......{...((((((..(((.((((((((((.....)))))))))).)))...((..]])).....))))))))))..((......((((....))))....))....]]].](((((..((((((..((.((((((..((((((((((......((........))..........(((((((...((((.(......(((.((.(.....).)).)))...)..))))...((.(((...(.(((.((....((((((.((....))...((((......))))..))))))....(((((.((((((....(.....((((((....)))))).)......)))))).....(((((.....)))))........)))))....))..)))....).)))))....)))))))...)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..)))))).....(((((.(.......).))))).......))...)))))).))).))..(.(..((...((((.(((..(((((((((((((..(.(((((..(((....)))..))))).)..)))))))))))))..))).))))....))...)..)..(.(((((((....))))))).)}........... Cryo-EM structure of a full archaeal ribosomal translation initiation complex in the P-REMOTE conformation; 16S ribosomal RNA 5jb3 5 18 5.34 27819266 272844 uggaggugauuuaaaugc .................. .................. Cryo-EM structure of a full archaeal ribosomal translation initiation complex in the P-REMOTE conformation; mRNA 5jbh 2 1495 5.34 RF00177,RF01959,RF01960 URS0000A763A7_272844 27819266 0003735 0005840 272844 auuccgguugauccugccggaggccacugcuauggggguccgacuaagccaugcgagucaagggggcgucccuucugggacgccaccggcggacggcucaguaacacgucgguaaccuacccucgggagggggauaaccccgggaaacuggggcuaaucccccauaggccugggguacuggaagguccccaggccgaaagggagccguaaggcccgcccgaggaugcggcggcggccgauuagguaguuggugggguaacggcccaccaagccgaagaucgguacgggccgugagagcgggagcccggagauggacacugagacacggguccaggcccuacggggcgcagcaggcgcgaaaccuccgcaaugcgggaaaccgcgacggggggacccccagugccgugccucuggcacggcuuuuccggaguguaaaaagcuccgggaauaagggcugggcaaggccgguggcagccgccgcgguaauaccggcggcccgagugguggccacuauuauugggccuaaagcggccguagccgggcccguaagucccuggcgaaaucccacggcucaaccguggggcucgcuggggauacugcgggccuugggaccgggagaggccggggguacccccgggguaggggugaaauccuauaaucccggggggaccgccaguggcgaaggcgcccggcuggaacggguccgacggugagcgcggaaggccaggggagcgaaccggauuagauacccggguaguccuggcuguaaaggaugcgggcuaggugucgggcgagcuucgagcucgcccggugccguagggaagccguuaagcccgccgccuggggaguacggccgcaaggcugaaacuuaaaggaauuggcgggggagcacuacaagggguggagcgugcgguuuaauuggauucaacgccgggaaccucaccgggggcgacggcaggaugaaggccaggcugaaggucuugccggacgcgccgagaggaggugcauggccgccgucagcucguaccgugaggcguccacuuaagugugguaacgagcgagacccgcgcccccaguugccagucccucccgcucgggaggaggcacucuggggggacugccggcgauaagccggaggaaggggcgggcgacgguaggucaguaugccccgaaacccccgggcuacacgcgcgcuacaaugggcgggacaaugggacccgaccucgaaaggggaagggaauccccuaaacccgcccucaguucggaucgcgggcugcaacucgcccgcgugaagcuggaaucccuaguacccgcgugucaucaucgcgcggcgaauacgucccugcuccuugcacacaccgcccgucacuccacccgagcggaguccgggugaggccugaucuccuucgggaggucaggucgagcccgggcuccgugaggggggagaagucguaacaagguaaccguaggggaaccuacggcucgaucaccuccu ...<<<<..[.((((.>>>>.<<<<<<<<<....<<<<.<<......<<<.<<<..<<<..<<.<<<<<<<<....>>>>>>>>.>>>>>......<<........<<<<<.<...<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<<<<<.<<<....>>>>>>>>>>>>....<<..<<<....>>>>>.>>>>>>>..>.>.>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<............>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>..>>>>...<<<<<<<<...>>>>>>>>...<<<<<<<.........>>>>>>>.....<<<<<((.....<<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((......<<....<<<.<<<<<<<.<<<<<<<<<.....<<<<<<<<.....>>>>>>>>....>>>>>>>..>>>>>>>>>...<<<<<<.....<<<<<<<<<<.<<<<<<<<<..<<<......>>>.....>>>>>>>>>.>>>.......<<....>>.>>>>>>>....>>>.>>>...>>>....>>....<<<<<<<...<<...<<<<.........>>>>...>>>>>>>>>.........<<<<<<..<<<<<<<<<<<<<<.....>>>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<...<<<<........<<<.<<<<.....>>>>.>>>......>>>>...<<.<<<..<<<<<<<<<....<<<<<<.<<....>>...<<<<......>>>>..>>>>>>....<<<<<.<<<<<<<...<...<.<<<<<<<..>>>>>>>>>.....>>>>>>>.....<<<<<.....>>>>>........>>>>>....>>>.>>>...>>>>>>>>....>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>.....<<<<<<.........>>>>>>.......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<..<<<<<<<<<<<<<..>>>>>>>>>>>>>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.......<<<<<<<....>>>>>>>.............. ...((((..[.[[[..)))).((((((.((....((((.(((.....(((.(((..(((..(..((((((((....))))))))..))))......(((.......(((((.(...(...(((((((.(((((....((((((....)))))).....)))))...(((((((((.((......)))))))))))....((..(((....))))).)))))))..).).))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).))..))))...((((.(((...))).))))....((((((.........))))))......((((.[[.....(((((.....((..]])).......))))).))))..)).))))))..........((([[...(..((....(((.(((((((.((((((..(......(((((((.....))))))).....)..))))..)))))))))..(((((((.....((((((.(((.((((((((...((........))......)))))))).))).......((....))..))))))....))).)))..))))....)).....((((((...((...((((.........))))...))))))))......{...((((((..(((.((((((((((.....)))))))))).)))...((..]])).....))))))))))..((......((((....))))....))....]]].](((((..((((.(..((.((((((..((((((((((......((........))..........(((((((...((((.(......(((.((.(.....).)).)))...)..))))...((.(((...(.(((.((....((((((.((....))...((((......))))..))))))....(((((.((((((....(.....((((((....)))))).)......)))))).....(((((.....)))))........)))))....))..)))....).)))))....)))))))...)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..)))))).....(((((.(.......).))))).......))...).)))).))).))..(.(..((...((((.(((..(((((((((((((..(.(((((..(((....)))..))))).)..)))))))))))))..))).))))....))...)..)..(.(((((((....))))))).)}........... Cryo-EM structure of a full archaeal ribosomal translation initiation complex in the P-IN conformation; 16S ribosomal RNA 5jbh 5 18 5.34 27819266 2260 uggaggugauuuaaaugc .................. .................. Cryo-EM structure of a full archaeal ribosomal translation initiation complex in the P-IN conformation; mRNA 5jbh 4 76 5.34 RF00005 URS0000A76384_562 27819266 0030533 0006412 562 gcgggguggagcagccuggnagcucgucgggnucauaacccgaagaucgucggnucaaauccggcccccgcuacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Cryo-EM structure of a full archaeal ribosomal translation initiation complex in the P-IN conformation; initiator Met-tRNA fMet from E. coli (A1U72 variant) 5jbj X 12 3.58 URS0000A76340_32630 27203181 32630 gguagcgcuacc ............ ............ Crystal structure of chicken LGP2 with 5'p 12-mer dsRNA at 3.6 A resolution; RNA (5'-R(P*GP*GP*UP*AP*GP*CP*GP*CP*UP*AP*CP*C)-3') 5jbj Y 12 3.58 URS0000A76340_32630 27203181 32630 gguagcgcuacc ............ ............ Crystal structure of chicken LGP2 with 5'p 12-mer dsRNA at 3.6 A resolution; RNA (5'-R(P*GP*GP*UP*AP*GP*CP*GP*CP*UP*AP*CP*C)-3') 5jc3 X 10 2.6 URS0000A76349_32630 27203181 32630 gguacguacc .......... .......... Crystal structure of chicken MDA5 with 5'p 10-mer dsRNA and ADP-Mg2+ at 2.6 A resolution (monoclinic form, twinned).; RNA (5'-R(P*GP*GP*UP*AP*CP*GP*UP*AP*CP*C)-3') 5jc3 Y 10 2.6 URS0000A76349_32630 27203181 32630 gguacguacc .......... .......... Crystal structure of chicken MDA5 with 5'p 10-mer dsRNA and ADP-Mg2+ at 2.6 A resolution (monoclinic form, twinned).; RNA (5'-R(P*GP*GP*UP*AP*CP*GP*UP*AP*CP*C)-3') 5jc3 C 10 2.6 URS0000A76349_32630 27203181 32630 gguacguacc .......... .......... Crystal structure of chicken MDA5 with 5'p 10-mer dsRNA and ADP-Mg2+ at 2.6 A resolution (monoclinic form, twinned).; RNA (5'-R(P*GP*GP*UP*AP*CP*GP*UP*AP*CP*C)-3') 5jc3 D 10 2.6 URS0000A76349_32630 27203181 32630 gguacguacc .......... .......... Crystal structure of chicken MDA5 with 5'p 10-mer dsRNA and ADP-Mg2+ at 2.6 A resolution (monoclinic form, twinned).; RNA (5'-R(P*GP*GP*UP*AP*CP*GP*UP*AP*CP*C)-3') 5jc7 X 24 2.75 URS0000A76337_32630 27203181 32630 ggacgucaugcgcaugacgucccc ........................ ........................ Crystal structure of chicken MDA5 with 5'p 24-mer dsRNA and ADP-Mg2+ at 2.75 A resolution.; RNA (5'-R(P*GP*GP*AP*CP*GP*UP*CP*AP*UP*GP*CP*GP*CP*AP*UP*GP*AP*CP*GP*UP*CP*CP*CP*C)-3') 5jc7 Y 24 2.75 URS0000A763A9_32630 27203181 32630 gggacgucaugcgcaugacguccc ........................ ........................ Crystal structure of chicken MDA5 with 5'p 24-mer dsRNA and ADP-Mg2+ at 2.75 A resolution.; RNA (5'-R(P*GP*GP*GP*AP*CP*GP*UP*CP*AP*UP*GP*CP*GP*CP*AP*UP*GP*AP*CP*GP*UP*CP*CP*C)-3') 5jc9 AA 1534 3.03 RF00177,RF01959,RF01960 URS0000A7637F_83333 27382179 0003735 0005840 83333 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcggcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<<....>>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<...<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<<..<<<.....>>>>>.....>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>.>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((.((.(.(....).).))..)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..........)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(..(.((((((((.......)))))))).)...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((.((....)).)))....(......)..))))).))).((.((....((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...))..))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Structure of the Escherichia coli ribosome with the U1052G mutation in the 16S rRNA; 16S rRNA 5jc9 BA 1533 3.03 RF00177,RF01959,RF01960 URS0000A7637F_83333 27382179 0003735 0005840 83333 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcggcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<......>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<...<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<<..<<<.....>>>>>.....>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>.>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((.((.(........).))..)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..........)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(..(.((((((((.......)))))))).)...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((.((....)).)))....(......)..))))).))).((.((....((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...))..))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Structure of the Escherichia coli ribosome with the U1052G mutation in the 16S rRNA; 16S rRNA 5jc9 CB 118 3.03 RF00001 URS0000049E57_83333 27382179 0003735 0005840 83333 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))). Structure of the Escherichia coli ribosome with the U1052G mutation in the 16S rRNA; 5S rRNA 5jc9 CA 2898 3.03 RF02540,RF02541 URS00004B0F34_83333 27382179 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccuu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<.>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<..<......>..>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<..<<....>>...>>>>>..>....>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>.. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((((...))).))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(...(........).).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((.(......).))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((((.(..........(((............((((((((....))))))))...................))).).)))).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).).....((.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..))....(.(((((....))).)).)....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))).. Structure of the Escherichia coli ribosome with the U1052G mutation in the 16S rRNA; 23S rRNA 5jc9 DB 120 3.03 RF00001 URS0000049E57_83333 27382179 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Structure of the Escherichia coli ribosome with the U1052G mutation in the 16S rRNA; 5S rRNA 5jc9 DA 2897 3.03 RF02540,RF02541 URS00004B0F34_83333 27382179 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<...>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<......>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<..<<....>>...>>>>>..>....>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<.<<<..<<<<<....<<<<<<<<....>>>>>>>>.>>>>>............>>>..>..>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((((...))).))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(...(........).).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((((......))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((..(((.(.........(((((...((......((((((((....))))))))...)).............)))))).)))..)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).).....((.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..))....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Structure of the Escherichia coli ribosome with the U1052G mutation in the 16S rRNA; 23S rRNA 5jcf X 10 2.6 URS0000A76349_32630 27203181 32630 gguacguacc .......... .......... Crystal structure of chicken MDA5 with 5'p 10-mer dsRNA and ADP-Mg2+ at 2.6 A resolution (orthorhombic form).; RNA (5'-R(P*GP*GP*UP*AP*CP*GP*UP*AP*CP*C)-3') 5jcf Y 11 2.6 URS0000A76388_32630 27203181 32630 agguacguacc ........... ........... Crystal structure of chicken MDA5 with 5'p 10-mer dsRNA and ADP-Mg2+ at 2.6 A resolution (orthorhombic form).; RNA (5'-R(P*AP*GP*GP*UP*AP*CP*GP*UP*AP*CP*C)-3') 5jcf C 10 2.6 URS0000A76349_32630 27203181 32630 gguacguacc .......... .......... Crystal structure of chicken MDA5 with 5'p 10-mer dsRNA and ADP-Mg2+ at 2.6 A resolution (orthorhombic form).; RNA (5'-R(P*GP*GP*UP*AP*CP*GP*UP*AP*CP*C)-3') 5jcf D 10 2.6 URS0000A76349_32630 27203181 32630 gguacguacc .......... .......... Crystal structure of chicken MDA5 with 5'p 10-mer dsRNA and ADP-Mg2+ at 2.6 A resolution (orthorhombic form).; RNA (5'-R(P*GP*GP*UP*AP*CP*GP*UP*AP*CP*C)-3') 5jch X 10 2.95 URS0000A76349_32630 27203181 32630 gguacguacc .......... .......... Crystal structure of chicken MDA5 with 5'p 10-mer dsRNA and ADP-Mg2+ at 2.95 A resolution (untwinned).; RNA (5'-R(P*GP*GP*UP*AP*CP*GP*UP*AP*CP*C)-3') 5jch Y 10 2.95 URS0000A76349_32630 27203181 32630 gguacguacc .......... .......... Crystal structure of chicken MDA5 with 5'p 10-mer dsRNA and ADP-Mg2+ at 2.95 A resolution (untwinned).; RNA (5'-R(P*GP*GP*UP*AP*CP*GP*UP*AP*CP*C)-3') 5jch U 10 2.95 URS0000A76349_32630 27203181 32630 gguacguacc .......... .......... Crystal structure of chicken MDA5 with 5'p 10-mer dsRNA and ADP-Mg2+ at 2.95 A resolution (untwinned).; RNA (5'-R(P*GP*GP*UP*AP*CP*GP*UP*AP*CP*C)-3') 5jch V 10 2.95 URS0000A76349_32630 27203181 32630 gguacguacc .......... .......... Crystal structure of chicken MDA5 with 5'p 10-mer dsRNA and ADP-Mg2+ at 2.95 A resolution (untwinned).; RNA (5'-R(P*GP*GP*UP*AP*CP*GP*UP*AP*CP*C)-3') 5jcs x 3394 9.5 RF02540,RF02543 URS000061F377_4932 26619264 0003735 0005840 4932 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaugguguuuugugcccucugcuccuuguggguaggggaaucucgcauuucacugggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguagugagggccuuggucagacgcagcgggcgugcuuguggacugcuugguggggcuugcucugcuaggcggacuacuugcgugccuuguuguagacggccuugguaggucucuuguagaccgucgcuugcuacaauuaacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauagaggguguagaauaagugggagcuucggcgccagugaaauaccacuaccuuuauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ..........................<..........................>...........<......>.............<<.....>>............................<<<<<<<...>>>>>>.>..............<..<<....<<..<.<.......<<.<<......<.<.......>>..(........<<......).>>....>>..>>.........>.>.....>.>...>>.>..........<<<<<........>>>>>.......<<<......{...{.>>>..............................................................<..<.....>.>..................................<<<<<.<<.<.....................<.<....<.....>...>.>...................<<..<.......<<<<.<.<<<<......<<<<<<<<........<<.........>>........>>>>>.>>>...>>>>..>.>>>>............<<<....>>>........>.>>......>.>>.>>>>>...................<.<<<........<<.<<<<.....<<...<<<<.....>>>>...>>...................<<<<.....<<.......>>.....>>>>....<<.<<..............>>..>>..........>>>>.>>......<<.....<<<<<......<<<<.<<<<...<.....<<<<<<<....>>>>>>>......>....<<<..<<.<<........>>>>.>>>....>>>.>>>>>...<<.......>>.......>>>>>........>>..<<<<........<<......>>..<<.<<<<<<....<<<........<...................<<......<<..........>>....>>..................>..........<<<<<..<......>.>>>.>>.........>>>..>>.>>>>.>>..<<.....<<.......>>.....>>......<<.....>>....<<<<.<.<..<<.(((......<<<<.......<...........<<..<<.<..<<........<.<...<<.....................>>.........<<......>>......>>....>>...>>>..>>..........))).>.....>>>>...>.>..>.>>>>><<<<.<<<............>>>>>>>......>>>><<.<<<<<<..<<......<<<<.<<<......>>>>>>>...>>.>>>>>>..>>.....>>>.>..<..............<<<.........>>>..<<<......<<<<.......<<<<<<.............>>>>>.>...<...{.<<<..<<.........................<<...........>>......>>....>>>...<..<.........>.>...><.<.<<<.<.<<...................[[<<<<<.....<<...<<<<<<..<<<..<<<<..(((..>>>>......<<<<<....<<<.<<....<<<.....>>>....>>.>>>.....>>>>>.....<<................>>>>>....>>>>>>...>>...........>>>>>.........>>....>>>>.>.>.}......................>>>>.<<<.......>>>...>>>..<<<<.....<........................<<<<.................>>>>.....<<<..<.....<<<<<.<..<................<.<<<<<....<.<.<<<<<<<<<<<<<....>>>>>>>>>>>>>..>>....>>>>>..>................>...<<<<.....>>>>......>>>>>>...........>...>>.>.................<<<<<.....<<...........>>..<<<<<<<.....<<<.....>>>.......>>>>>>>.......<<<....<<<<.<....<....<<<........>.>>...>..>>>>>....>>>.<<<<<.......>>>>>.........<............<<<<.......>>>>......>...............>>>>>................>.>>>>......>.........<<.......>>...........<..<<..<.........<.....<......<<<.<...<.........<<..................................................................>>..........<<.....<.<...<..............>..........]].....<<<......>>>......>>..>>...........>...>..>>>.................................................<<<<<.....<<<<<.......>>>>>......<....(((.>......>>>>>....<<<<<<<.........>>>.>>>>.<<......>>...))).......<<<<<<.......}...}.....>>>>>>.............>.....>................<<<.<....<<.......>>.....>>>>..................<<..<.<<<.........<<........>>.........<<<.........>>>......>>>...>....>>.......<<<.<<<....>>>..>>>.....>...>>.>.........<<<<<<<.......<.<<<.<<...............>>.>>>.>..<<<....<<<......<<<.<<<.)))..>>>...>>>.....>>>...>>>.....<......<................>......>..........>>>>>>>.........<<......<.......<<..........<<<<<<.....>>>>>>......>>.......<<<.<<...<......<.<<<......>>>..>.....>.>>.>>>.................>.....>>...<<<<<.....................<<<<.<<...<<<....<<.<.......<.<.....>.>......>>>...>>>......>>..>>>>..>>>>>.. ...............................................................................(......((.....))......)......................((.(((...))).))..................((....((.(..(......(.((.........((........))..............................).)).........).....).))...).)...........(..((........))..)........(..............)...............................................................(.(.......))...................................((((.(.(((.....................(...............)........................((........(.(((..(((.........(.(((.............................))).).......)))...))).).............(((....))).......))........))).).))))..(................((..((....(...(..((((...........((.......)).........................(((......(((....)).)......)))....((.((..............))..))..........))))..)...)...(.....((((((......((.(..((...(......((((((....)))))).......)..........(.((........))).........))...))).....(.......).......))))))........)...((((........(((....)))....((..((((........(.(......................((.........................)).....................)......(..(((..(......).)))..).......).....))))..)).....((......(.......)......)).....(........)....((.(((.......((....[.....[......................((.((.............((....(....(...........)....)..........(........).....)).........)).))..............)).......]....].......))).))(((...(.............)...)))......)))).(.((((((..(.......((((.((((....))))))))....).))))))..)......))..))((...............((.........))....(.(.....((((........(((((.............)))))................((.........................((...........))......)).........(................).........(...(.....................[((((.......((...(.((.....(..(((.........)))......(((((....((((.......((.....)).......)))).....)))))........(............)...).......)).)...)).............))))..........).....)....................(......)..)))).(((.......)))...))...((((.........(.......((....).......(((.....(....)......)))..(..(((...(......((..(..........(.........(..(..(...(.........(.(..(.(....).)..).).........)...)..)...)..........).........((((.....))))......)..))............)....)))..)..............((.((.(....((.........))...(...((.........................))...)..............((...(...((......................)).)..))........(.((.........)).)......................((((.......)))).....................))).)).....).....)......))))......))..............)............(..(.................(....(.......((...(..................................................................................................(((..............................]....((.(......).).)...)))..................)...))....................................................((((....(..(.........)..)......(.....[..)....).)))......(((..((.........))...))).(((....)))....].........((.((.................)).))..............)....)..................((.(...................).))....................((...(((..............................(((.........)))......))).......))........(...(((....)))....)............)..)......(.(((((.........((.(.......(....).......))).....((...(.((.....((((.(..........)...))))....)).)..))................................................))))).).........((......(.......(...........((((.(.....).)))).......).......(.(..........(.(...((......))...).)........).).................).....))....((((.(.............)......(((.......(......(......(...(......)...).....).....)...........)))...))))... CRYO-EM STRUCTURE OF THE RIX1-REA1 PRE-60S PARTICLE; 25S ribosomal RNA 5jcs y 158 9.5 RF00002 URS00001BF64E_4932 26619264 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu ..........................................<<<<<.((.....>>>.......<<.......))...............>>.......>>....<<.....>><<<<<<<<......>>>>>>>>..................... .............................................((.[[.....))...........(.....]]............)...........................((((.((......)).))))...................... CRYO-EM STRUCTURE OF THE RIX1-REA1 PRE-60S PARTICLE; 5.8S ribosomal RNA 5jcs z 121 9.5 RF00001 URS000055688D_4932 26619264 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<.......<<<<<........<<..............>>..........>>>>>......<<<<............<.<......>.>.........>>>>..>>>>>>>>>. .(((((((.........(((..........((............))............))).......((((..............((....))...........))))...))))))).. CRYO-EM STRUCTURE OF THE RIX1-REA1 PRE-60S PARTICLE; 5S ribosomal RNA 5jte AA 1539 3.6 RF00177,RF01959,RF01960 URS000080DDC0_562 27380950 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<......>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<...<....>.>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((((((......)))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((((.......)))))))).....)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.((((.((..(...(.((.(...(((((((....)))))))..............).))..)).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)).)))))..)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Cryo-EM structure of an ErmBL-stalled ribosome in complex with A-, P-, and E-tRNA; 16S ribosomal RNA 5jte AV 10 3.6 27380950 562 guagauaaaa .......... .......... Cryo-EM structure of an ErmBL-stalled ribosome in complex with A-, P-, and E-tRNA; mRNA 5jte AW 74 3.6 RF00005 URS00021ED9A1_562 27380950 0030533 0006412 562 gggucgunagcucaggguagagcaguugacunuunaucaauugnncgcaggnucgaauccugcacgacccacca <<<<<<<..<<<<......>>>><<<<<<.......>>>>>>....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[..))))(((((.........)))))....(((((..]....)))))))))))).... Cryo-EM structure of an ErmBL-stalled ribosome in complex with A-, P-, and E-tRNA; A-site Lysine tRNA Lysine 5jte AX 77 3.6 RF00005 URS000009EE82_562 27380950 0030533 0006412 562 ggagcggnaguucagucgguuagaauaccugccunucncgcaggggnucgcgggnucgagucccguccguuccgcca <<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((.(((..((((.........)))).(((((.......))))).....(((((.......)))))))).))).... Cryo-EM structure of an ErmBL-stalled ribosome in complex with A-, P-, and E-tRNA; P-site tRNA Aspartate 5jte AY 71 3.6 RF00005 URS0000E60BC5_562 27380950 0030533 0006412 562 gggugaunagcucaggggagagcaccucccunacnaggaggggnucggcggnucgaucccgucaucaccca <<<<<<<..<<<<......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>. (((((((..((((......)))).(((((.......))))).....(((((.......)))))))))))). Cryo-EM structure of an ErmBL-stalled ribosome in complex with A-, P-, and E-tRNA; E-site tRNA Valine 5jte BA 2897 3.6 RF02540,RF02541 URS0000A7632D_562 27380950 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<.>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<<..<<...........>>..>>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((.(..(((...((.....))...)))...((....))..((((.....)))).....)).))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...).)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((((((.)))).))...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(.(..(((.........)))..).)........(.(......).)..)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((.(......).))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((.(....).)))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((...((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((((.(.........(((((..(((......((((((((....))))))))...)))............)))))).)))).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Cryo-EM structure of an ErmBL-stalled ribosome in complex with A-, P-, and E-tRNA; 23S ribosomal RNA 5jte BB 118 3.6 RF00001 URS00008116C5_562 27380950 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (((((((((.....((((((((....(((.(((...(.....)...)))...)))...)))))).)).((.......((((((((...)))))))).......))...))))))))). Cryo-EM structure of an ErmBL-stalled ribosome in complex with A-, P-, and E-tRNA; 5S ribosomal RNA 5ju8 AA 1539 3.6 RF00177,RF01959,RF01960 URS000080DDC0_83333 27380950 0003735 0005840 83333 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<......>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<...<....>.>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((((((......)))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((((.......)))))))).....)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(.((.(....((((((....))))))...............).))..)).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....))))))))..)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Cryo-EM structure of an ErmBL-stalled ribosome in complex with P-, and E-tRNA; 16S ribosomal RNA 5ju8 AV 10 3.6 27380950 562 guagauaaaa .......... .......... Cryo-EM structure of an ErmBL-stalled ribosome in complex with P-, and E-tRNA; mRNA 5ju8 AX 77 3.6 RF00005 URS000009EE82_83333 27380950 0030533 0006412 83333 ggagcggnaguucagncggnnagaauaccugccunucncgcaggggnucgcgggnucgagucccguccguuccgcca <<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((.(((..((((.........)))).(((((.......))))).....(((((.......)))))))).))).... Cryo-EM structure of an ErmBL-stalled ribosome in complex with P-, and E-tRNA; P-site tRNA Aspartate 5ju8 AY 71 3.6 RF00005 URS0000E60BC5_83333 27380950 0030533 0006412 83333 gggugaunagcucaggggagagcaccucccunacnaggaggggnucggcggnucgaucccgucaucaccca <<<<<<<..<<<<......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>. (((((((..((((......)))).(((((.......))))).....(((((.......)))))))))))). Cryo-EM structure of an ErmBL-stalled ribosome in complex with P-, and E-tRNA; E-site tRNA Valine 5ju8 BA 2897 3.6 RF02540,RF02541 URS000080E25C_83333 27380950 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<.>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<...........>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((.......(((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)).....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((.(..(((...((.....))...)))...((....))..((((.....)))).....)).))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...).)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((((((.)))).))...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(.(..(((.........)))..).)........(.(......).)..)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((..........))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((.(....).)))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((...((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((((.(.........(((((..(((......((((((((....))))))))...)))............)))))).)))).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Cryo-EM structure of an ErmBL-stalled ribosome in complex with P-, and E-tRNA; 23S ribosomal RNA 5ju8 BB 118 3.6 RF00001 URS00008116C5_83333 27380950 0003735 0005840 83333 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (((((((((.....((((((((....(((.(((...(.....)...)))...)))...)))))).)).((.......((((((((...)))))))).......))...))))))))). Cryo-EM structure of an ErmBL-stalled ribosome in complex with P-, and E-tRNA; 5S ribosomal RNA 5juo A 1781 4.0 RF01960,RF01959,RF00177 URS000080E2D9_4932 27159452 0003735 0005840 4932 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucau ...<<<<..{.[[[[.>>>><<<<.<<<<<......<..........<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<..<<..<<....<<<..................<.....<<..<.......>..>>......>.........<<<<<............>>>>><...<<<<<<......((((((..<<......>>..............>>>>>>.....>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>..>>>.......>.......<<.<<<<<..............>>>>>..>>......<<..<...........>..>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>...>>>>>>>>>.........<<<[[.....<.<<...<<<.<<....<<<<<<.<<<<.....<..>.....>>>>.>>>>>>.....<<<<<...............................>>>>>....<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>..............<.<<<<<.......))))))..>>>>>.>.........>>....<<.<<<.<<...<<<<..<<<.<<<<<<.....<<<......>>>........>>>>>.>>>>.......<<....>>...>>>>..>>.>>>..>>...>>>...>>.>....<<.<<.....<...<<<<.<.....>.>>>>...>..>>.>>..........<<<.<<.<<.<.<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..]]>>...>>.....>>>.>>>.<<<......<<<......>>>....>>>..]]]].}.<<<<.<<<<<<<..<<.<<<<<...<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<..<..........>..>>......>>>>>...<<.<<<....<<<<<<.....<<<.<<<<......>>...<<<......>>>...>>.>>>....<<<<..<<..<.<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>.>.>>....<<<<<<.....>>>>>>........>>>>.....>>.>>>...>...>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<...<<<....>>>...>>....>>.......>>>>>>>......<....<<<<<<..........>>>>>>....>......>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>........<<....<<<<.<<....<<<<<<<<.<<<....<<......<<<<<<..<..<..<.......>...>..>..>>>>>>......>>....>>>.>>>>>>>>...>>.>>>>.....>>..........<<<<<<<<....>>>>>>>>........ ...((((..[.[[[[.))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[[[[[[[(((....))).....(......).)))))).)...).(.((((..((.(..)..)).)))))...)))...))))..))).((.....(((....((((((((.......))))))))))).......))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....((..(((................)))...))......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.((((......()......)))).))))))....((((((...............................))))))...(((((.((.......((..((.......)).((.......))....))......)).))..))).........(....(.((.(((....]]]]]]]].))).)).)...).....))...(((..((.((...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)).))...))..))))...)).)....((((((....(...((.(.........).))...).))))))......<...(((.((.(((..(((.((((.(((........))))))).)))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))..]]]].](((((.(((((((..((..(((.(..(((..(((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(..(((((....(((.((.((....))...(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))......).))))).....).)))))...)).)))..))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..).))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...((.(((..(....................)..))).))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>...... Saccharomyces cerevisiae 80S ribosome bound with elongation factor eEF2-GDP-sordarin and Taura Syndrome Virus IRES, Structure I (fully rotated 40S subunit); 18S ribosomal RNA 5juo B 3309 4.0 RF02540,RF02543 URS000061F377_4932 27159452 0003735 0005840 4932 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Saccharomyces cerevisiae 80S ribosome bound with elongation factor eEF2-GDP-sordarin and Taura Syndrome Virus IRES, Structure I (fully rotated 40S subunit); 25S ribosomal RNA 5juo C 158 4.0 RF00002 URS00001BF64E_4932 27159452 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<.<<<<((....>>>>.......<<<......))..............>>>.......>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... ..........................................(((((.[[.....))).....(.((((.....]]............).)))..)...)).....((.....))(((((((((....)))))))))..................... Saccharomyces cerevisiae 80S ribosome bound with elongation factor eEF2-GDP-sordarin and Taura Syndrome Virus IRES, Structure I (fully rotated 40S subunit); 5.8S ribosomal RNA 5juo D 121 4.0 RF00001 URS000055688D_4932 27159452 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<.....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>.>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Saccharomyces cerevisiae 80S ribosome bound with elongation factor eEF2-GDP-sordarin and Taura Syndrome Virus IRES, Structure I (fully rotated 40S subunit); 5S ribosomal RNA 5juo EC 198 4.0 URS0000A76394_142102 27159452 142102 aaacuccauguauugguuacccaucugcaucgaaaacucuccgaacacuaggugcaguaaggcuuucauggagugguuugcuauuuagcguacguguaccauaggcagccccaaaaacacguaggagaaagucccagucacuuugggcaaaguagacagccgcgcuugcguggugggacuuaauuaaugccugcuaac ...<<<<<<<..............<<<<<<.......(((((.........>>>>>>.........>>>>>>>.(((.<<<<....>>>>..<<<<<)))....<....>......>>>>>..)))))..<<<<<.<<<..<..(((...>...>>>..<<<<<....>>>>>.>>>>>..........)))...... ...(((((((..............(((((((......[[[[[........))))))).........)))))))[[[[..(((....)))...(((((]]]](.((.....)).)..)))))..]]]]]..(((((.(((((((..[[[[)))).))).((((((....)))))))))))........]]]]....... Saccharomyces cerevisiae 80S ribosome bound with elongation factor eEF2-GDP-sordarin and Taura Syndrome Virus IRES, Structure I (fully rotated 40S subunit); IRES 5jup A 1781 3.5 RF01960,RF01959,RF00177 URS000080E2D9_4932 27159452 0003735 0005840 4932 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Saccharomyces cerevisiae 80S ribosome bound with elongation factor eEF2-GDP-sordarin and Taura Syndrome Virus IRES, Structure II (mid-rotated 40S subunit); 18S ribosomal RNA 5jup B 3309 3.5 RF02540,RF02543 URS000061F377_4932 27159452 0003735 0005840 4932 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Saccharomyces cerevisiae 80S ribosome bound with elongation factor eEF2-GDP-sordarin and Taura Syndrome Virus IRES, Structure II (mid-rotated 40S subunit); 25S ribosomal RNA 5jup C 158 3.5 RF00002 URS00001BF64E_4932 27159452 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<<<<....>>>>.....<.<<<......>>..............>>>..>...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Saccharomyces cerevisiae 80S ribosome bound with elongation factor eEF2-GDP-sordarin and Taura Syndrome Virus IRES, Structure II (mid-rotated 40S subunit); 5.8S ribosomal RNA 5jup D 121 3.5 RF00001 URS000055688D_4932 27159452 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Saccharomyces cerevisiae 80S ribosome bound with elongation factor eEF2-GDP-sordarin and Taura Syndrome Virus IRES, Structure II (mid-rotated 40S subunit); 5S ribosomal RNA 5jup EC 198 3.5 URS0000A76394_142102 27159452 142102 aaacuccauguauugguuacccaucugcaucgaaaacucuccgaacacuaggugcaguaaggcuuucauggagugguuugcuauuuagcguacguguaccauaggcagccccaaaaacacguaggagaaagucccagucacuuugggcaaaguagacagccgcgcuugcguggugggacuuaauuaaugccugcuaac ...<<<<<<<..............<<<<<<.......(((...........>>>>>>.........>>>>>>>.(((.<<<<....>>>>..<<<<.)))...<<.....>>.....>>>>....)))..<<<<<.<<<<<<..(((((.>>>.>>>.<<<<<<....>>>>>>>>>>>........)))))...... ...(((((((..............(((((........[[[[[..........))))).........)))))))[[[[.((((....))))..(((((]]]](.((.....)).)..)))))..]]]]]..(((((.(((((((.[[[[[)))).))).((((((....)))))))))))........]]]]]...... Saccharomyces cerevisiae 80S ribosome bound with elongation factor eEF2-GDP-sordarin and Taura Syndrome Virus IRES, Structure II (mid-rotated 40S subunit); IRES 5jus A 1781 4.2 RF01960,RF01959,RF00177 URS000080E2D9_4932 27159452 0003735 0005840 4932 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Saccharomyces cerevisiae 80S ribosome bound with elongation factor eEF2-GDP-sordarin and Taura Syndrome Virus IRES, Structure III (mid-rotated 40S subunit); 18S ribosomal RNA 5jus B 3309 4.2 RF02540,RF02543 URS000061F377_4932 27159452 0003735 0005840 4932 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Saccharomyces cerevisiae 80S ribosome bound with elongation factor eEF2-GDP-sordarin and Taura Syndrome Virus IRES, Structure III (mid-rotated 40S subunit); 25S ribosomal RNA 5jus C 158 4.2 RF00002 URS00001BF64E_4932 27159452 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.......<<<......>>..............>>>......>>>....<<.....>><<<<<<.<<....>>.>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Saccharomyces cerevisiae 80S ribosome bound with elongation factor eEF2-GDP-sordarin and Taura Syndrome Virus IRES, Structure III (mid-rotated 40S subunit); 5.8S ribosomal RNA 5jus D 121 4.2 RF00001 URS000055688D_4932 27159452 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu .<<<<<<<.....<<<<<<<<.....<<.<<.....<.....>..>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>.>>>>>>>.. (.(((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))).). Saccharomyces cerevisiae 80S ribosome bound with elongation factor eEF2-GDP-sordarin and Taura Syndrome Virus IRES, Structure III (mid-rotated 40S subunit); 5S ribosomal RNA 5jus EC 198 4.2 URS0000A76394_142102 27159452 142102 aaacuccauguauugguuacccaucugcaucgaaaacucuccgaacacuaggugcaguaaggcuuucauggagugguuugcuauuuagcguacguguaccauaggcagccccaaaaacacguaggagaaagucccagucacuuugggcaaaguagacagccgcgcuugcguggugggacuuaauuaaugccugcuaac ...<<<<<<<..............<<<<<<..........[[.........>>>>>>.........>>>>>>>.(((.<<<<<..>>>>>..<<<<<)))...<<.....>>....>>>>>..]].......(((.(((..(..<<<<..)...))).<..............>)))...........>>>>...... ...(((((((..............((((((.......[[[[[.........)))))).........)))))))[[[[.((((....))))..(((((]]]](.((.....)).)..)))))..]]]]]..(((((.(((((((..[[[[)))).))).((((((....)))))))))))........]]]]....... Saccharomyces cerevisiae 80S ribosome bound with elongation factor eEF2-GDP-sordarin and Taura Syndrome Virus IRES, Structure III (mid-rotated 40S subunit); IRES 5jut A 1781 4.0 RF01960,RF01959,RF00177 URS000080E2D9_4932 27159452 0003735 0005840 4932 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Saccharomyces cerevisiae 80S ribosome bound with elongation factor eEF2-GDP-sordarin and Taura Syndrome Virus IRES, Structure IV (almost non-rotated 40S subunit); 18S ribosomal RNA 5jut B 3309 4.0 RF02540,RF02543 URS000061F377_4932 27159452 0003735 0005840 4932 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Saccharomyces cerevisiae 80S ribosome bound with elongation factor eEF2-GDP-sordarin and Taura Syndrome Virus IRES, Structure IV (almost non-rotated 40S subunit); 25S ribosomal RNA 5jut C 158 4.0 RF00002 URS00001BF64E_4932 27159452 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Saccharomyces cerevisiae 80S ribosome bound with elongation factor eEF2-GDP-sordarin and Taura Syndrome Virus IRES, Structure IV (almost non-rotated 40S subunit); 5.8S ribosomal RNA 5jut D 121 4.0 RF00001 URS000055688D_4932 27159452 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Saccharomyces cerevisiae 80S ribosome bound with elongation factor eEF2-GDP-sordarin and Taura Syndrome Virus IRES, Structure IV (almost non-rotated 40S subunit); 5S ribosomal RNA 5jut EC 198 4.0 URS0000A76394_142102 27159452 142102 aaacuccauguauugguuacccaucugcaucgaaaacucuccgaacacuaggugcaguaaggcuuucauggagugguuugcuauuuagcguacguguaccauaggcagccccaaaaacacguaggagaaagucccagucacuuugggcaaaguagacagccgcgcuugcguggugggacuuaauuaaugccugcuaac ...<<<<<<<..............<.<<.<.......[.[...........>.>>.>.........>>>>>>>.((...<<<....>>>...<<<<<.))....<....>......>>>>>....].]..<<<<..<<<<<<<.((((.>>>>.>>>.<<<<.<....>.>>>>.>>>>.........))))...... ...(((((((..............((((.........[[[[[...........)))).........)))))))[[[[..(((....)))...(((((]]]]..((.....))....)))))..]]]]]..(((((.(((((((..[[[[)))).))).(((.((....)).))))))))........]]]]....... Saccharomyces cerevisiae 80S ribosome bound with elongation factor eEF2-GDP-sordarin and Taura Syndrome Virus IRES, Structure IV (almost non-rotated 40S subunit); IRES 5juu A 1781 4.0 RF01960,RF01959,RF00177 URS000080E2D9_4932 27159452 0003735 0005840 4932 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Saccharomyces cerevisiae 80S ribosome bound with elongation factor eEF2-GDP-sordarin and Taura Syndrome Virus IRES, Structure V (least rotated 40S subunit); 18S ribosomal RNA 5juu B 3307 4.0 RF02540,RF02543 URS000061F377_4932 27159452 0003735 0005840 4932 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Saccharomyces cerevisiae 80S ribosome bound with elongation factor eEF2-GDP-sordarin and Taura Syndrome Virus IRES, Structure V (least rotated 40S subunit); 25S ribosomal RNA 5juu C 158 4.0 RF00002 URS00001BF64E_4932 27159452 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<<<<....>>>>.....<.<<<......>>..............>>>..>...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Saccharomyces cerevisiae 80S ribosome bound with elongation factor eEF2-GDP-sordarin and Taura Syndrome Virus IRES, Structure V (least rotated 40S subunit); 5.8S ribosomal RNA 5juu D 121 4.0 RF00001 URS000055688D_4932 27159452 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<<............>>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Saccharomyces cerevisiae 80S ribosome bound with elongation factor eEF2-GDP-sordarin and Taura Syndrome Virus IRES, Structure V (least rotated 40S subunit); 5S ribosomal RNA 5juu EC 198 4.0 URS0000A76394_142102 27159452 142102 aaacuccauguauugguuacccaucugcaucgaaaacucuccgaacacuaggugcaguaaggcuuucauggagugguuugcuauuuagcguacguguaccauaggcagccccaaaaacacguaggagaaagucccagucacuuugggcaaaguagacagccgcgcuugcguggugggacuuaauuaaugccugcuaac ......<<<<...............<<<<<.......(((.(.........>>>>>..........>>>.>...(.....<......>.....<<....)...<.......>......>>....))))..<<<<<.<<<<<<<.((((.>>>>.>>>.<<<<<<....>>>>>>>>>>>.........))))...... ...(((((((..............(((((((......[[[[[........))))))).........)))))))...[.(((......))).((((((]..................)))))).]]]]]..(((((.(((((((..[[[[)))).))).((((((....)))))))))))........]]]]....... Saccharomyces cerevisiae 80S ribosome bound with elongation factor eEF2-GDP-sordarin and Taura Syndrome Virus IRES, Structure V (least rotated 40S subunit); IRES 5jvg X 2710 3.428 RF02540,RF02541 URS0000A76330_243230 27791159 0003735 0005840 243230 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.<<<<<<<......<<<<<<<<<<<....<<<..<<<<<<<<<<<<......<<<<<<<((..((>>>>.....<<<<<<...<<.))..))..>>......>>>>>>...>>>....<<<....>>><<<<<....>>>>><<<<....>>>>>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<......<<.....>>.....>>>>...<<<....<<<<<.<<....>>.>>>>>......<<<....<<..<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>....>>.>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>..............<<....>>....>>.........<<<<....>>>>.............>....>>>>>>>>>>>.......<<<<<<<<<<.......>>>>>>>>>>...<.<........>.>.<<<<<<....<<<.<<<<<<<<<<..<<<...<<<....>>>...>>>...<<....>>...<<......>>.........>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<.....<<<<<.>>>>>......>>>...<<<<.<.<<........>>.>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<...<<<..<<<<<<...<<<...<<<.<<<<.....>>>>.>>>..>>.>...>>>>>>...>>>..>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><..<<<<......>>>>..>....>>>>>><.<<<<<<<.<<......<<<<<.<<....>>.>>>>>...>>.>>>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<<..>>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<...<<...<<<<....<<<<..<<<..<<<<<.<<<<.<<..[[[....>>>>>><<<<<<<.<<..<<<<<<<<<<...<<.....>>.>>>>>>..>>>>..>>>>>>>>>...<<<<<....>>>>>....>>>>>...>>>...>>>>.........>>>>...>>......>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<...>>>>>>>>............<<<<<<<<<..<<...........>>..<<<<<<<.....<<<.....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>>.............<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<..>>>>>>>>>>>>...<<<<<<........>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<<.....>>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<.<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>..>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.]]]>>>>>>...>>>>>...>>>>.>>>>>....<<....<<<<<...........>>>>>....>>..>>>>.......>>>>>>>..<<.>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>>.. .(((((((......((((((((((.....(((..(((.((((((((......((((((.[[..[[.))).....((((((...((.]]..]]..))......))))))...)))....(((....)))(((((....)))))((((....))))))...((((((.....(...[..)......))))).).........((....))...((((......((.]...)).....))))...((((...((((.(((....)).)))))....{.(((....((..(((...(((((......)))))[[(...).(((.....]])))...)))....)).))))....((((((((..[......))))))))....}.(((((].[[[[)))))..)))......)).)))).).))..............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.[..).)))))))))).<.(.(........).).((((((....(((.((((((((((..(((...(((....)))...)))...((....))...((......)).........)))))))))))))..((.(...((((((.....((((((((((.((((....(((((.)))))....)<)))...(((..(.((........)).).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((...((((.((((((...(((...(((.((((.....)))).)))..)).)...)))))).).)))..))))))).))..(((((((.((......)).)))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......(((((.(((..(((.........)))..))).........((......))...)))))...)))))))))).))..........]]].)....))))))))))...)))))))(..((.(((..))).))..)....))))))(.(((((((.((......(((((.((....))])))))...)).)))))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((((((...((...((((....(((((.(((..(((((.((((.((...{{....))))))(((((((.((..((.(((((((...((.....)).))))))..).))..)))))))))...(((((....)))))....)))))...)))..)))))(..).....))))...))......))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.[..).....)))))((((((((...))))))))(...).......(((((((((.>.(...........)...(((((((.....(((.....))).......))))))).]((((.(((..(((((((..(((...((...((((......))))...))...))))))))..))))).............((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).[..(((((.....>].)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((.(..(..)..).)))))))...((((.(........).))))....))))).)))..)))))..(((......[)))((((((..........]))))))([.(...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).).]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))....)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))....((....((((.............))))....))..))))..]....)))))))(.((.))....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))...)))))))).. The large ribosomal subunit from Deinococcus radiodurans in complex with avilamycin; 23S ribosomal RNA 5jvg Y 120 3.428 RF00001 URS0000420396_243230 27791159 0003735 0005840 243230 acccccgugcccauagcacuguggaaccaccccaccccaugccgaacugggucgugaaacacagcagcgccaaugauacucggaccgcagggucccggaaaagucggucagcgcgggggu <<<<<<<<<<.....<<.<<<<<....<<<<<<<.............>>>>..>>>...>>>>>..>><<<.......<<.<<<<<....>>>>>.>>.......>>>..>>>>>>>>>> (((.((((((.....((...(((....(((((((...(.....)...))))..)))...)))....)).((.......((.(((((....))))).)).......))...)))))).))) The large ribosomal subunit from Deinococcus radiodurans in complex with avilamycin; 5S ribosomal RNA 5jvh X 2658 3.58 RF02540,RF02541 URS000080DEF1_243230 27791159 0003735 0005840 243230 ggucaagauaguaaggguccacgguggaugcccuggcgcuggagccgaugaaggacgcgauuaccugcgaaaagccccgacgagcuggagauacgcuuugacucggggauguccgaauggggaaacccaccucguaagagguauccgcaaggaugggaacucagggaacugaaacaucucaguaccugaaggagaagaaagagaauucgauuccguuaguagcggcgagcgaacccggaucagcccaaacucaagccgaaguggcuggaaagcuacaccucagaaggugagaguccuguaggcgaacgagcuaggucguuguucgugaaacgaugacugaauccgcgcggaccaccgcgcaaggcuaaauacucccagugaccgauagcgcauaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaagagaaccugaaaccguggacuuacaagcagucauggcaccuuaugcguguuauggcgugccuauugaagcaugagccggcgacuuagaccugacgugcgagcuuaaguugaaaaacggaggcggagcgaaagcgaguccgaauagggcggcauuaguacgucgggcuagacucgaaaccaggugagcuaagcaugaccagguugaaacccccgugacagggggcggaggaccgaaccggugccugcugaaacagucucggaugaguuguguuuaggagugaaaagcuaaccgaaccuggagauagcuaguucuccccgaaauguauugagguacagccucggauguugaccauguccuguagagcacucacaaggcuaaaccuuaugaaacuccgaaggggcacgcguuuaguccgggagugaggcugcgagagcuaacuuccguagccgagagggaaacaacccagaccaucagcuaaggucccuaaaugaucgcucagugguuaaggaugugucgucgcauagacagcuggcuuagaagcaugcguaauagcucacuggucgagugacgaugcgccgaaaaugaucggggcucaagugaucuaccgaagcuauggauucaacucgcgaagcgaguugucugguaggggagcguucaguccgcggagaagccauaccggaaggagugguggagccgacugaagugcggaugccggcaugaguaacgauaaaagaagugagaaucuucuucgccguaaggacaaggguuccuggggaagggucguccgcccagggaaagucgggaccuaaggugaggccgaacggcgcagccgauggacagcaggucaagauuccugcaccgaucauguggagugauggagggacgcauuacgcuauccaaugccaagcuauggcuaugcugguugguacgcucaagggcgaucgggucagaaaaucuaccggucacaugccucagacguaucgggagcuuccucggaagcgaaguuggaaacgcgacggugccaagaaaagcuucuaaacguugaaacaugauugcccguaccgcaaaccgacacagguguccgagugucaaugcacuaaggcgcgcgagagaacccucguuaaggaacuuugcaaucucaccccguaacuucggaagaagggguccccacgcuucgcguggggcgcagugaauaggcccaggcgacuguuuaccaaaaucacagcacucugccaacacgaacaguggacguauagggugugacgccugcccggugccggaaggucaaguggagcggugcaagcugcgaaaugaagccccggugaacggcuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaggcguaacgaucugggcgcugucucaacgagggacucggugaaauugaauuggcuguaaagaugcggccuacccguagcaggacgaaaagaccccguggagcuuuacuauagucuggcauugggauucggguuucugaaacuuggauuucuaaccugaaaaaucacuuucggggaccgugcuuggcggguaguuugacuggggcggucgccucccaaaauguaacggaggcgcccaaaggucaccucaagacgguuggaaaucgucuguagagcgcaaagguagaagguggcuugacugcgagacugacacgucgagcagggaggaaacucgggcuuagugaaccggugguaccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagaguccauaucggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgcuacgggcgcaggagaauugaggggaguugcuccuaguacgagaggaccggagugaacggaccgcuggucucccugcugucguaccaacggcacaugcaggguagcuauguccggaacggauaaccgcugaaagcaucuaagcgggaagccagccccaagaugaguucucccacugagguaagacucccggaagaccaccggguuaagaggccaggcgugcacgcauagcaauguguucagcggacuggugcucaucagucgaggucuugacca .<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.[...((.>>>.....<<<<<<...<<.))...]..>>......>>>>>>...>>>....<<<....>>><<<<<....>>>>><<<<....>>>>>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<......<<.....>>.....>>>>...<<<.....<<..<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>....>>....<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>..............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<.......>>>>>>>>>>...<.<........>.>.<<<<<<....<<<.<<<<<<<<<<..<<<...<<<....>>>...>>>...<<....>>...<<......>>.........>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<.....<<<<<......>>>>>......>>>...<<<..<.<<........>>.>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<...<<<<.<<<<<<...<<<...<<<.<<<<.....>>>>.>>>..>>.>...>>>>>>.>.>>>..>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<...............<<......>>.......>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><..<<<<<<<.....>>>>>>>..>....>>>>>>..<<<<<<<.<<......<<<<<.<<....>>.>>>>>...>>.>>>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<<..>>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<...<<...<<<<....<<<<..<<<..<<<<<.<<<<.<<...[[....>>>>>><<<<<<<.<<..<<<<<<<<<<...<<.....>>.>>>>>>....>>>>..>>>>>>>>>...<<<<<....>>>>>....>>>>>...>>>...>>>>.........>>>>...>>......>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<...>>>>>>>>............<<<<<<<<<..<<...........>>..<<<<<<<.....<<<.....>>>.......>>>>>>>.<<<<<..<<..<<<<<<<..<<<...<....<<<<<....>>>>>....>...>>>>>>>>..>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<.>>>>>>>>>>>>>>...<<<<<<........>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<.<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>..>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.]].>>>>>>...>>>>>...>>>>.>>>>>....<<....<<<<<...........>>>>>....>>..>>>>.......>>>>>>>..<<.>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>>.. ...(((((......((((((((((.....(((..((((((((((((......((((((.[...[[.))).....((((((...((.]]...]..))......))))))...)))....(((....)))(((((....)))))((((....))))))...((((((.....(...[..)......))))).).........((....))...((((......((.]...)).....))))...(((.....((..(((...(((((......)))))[[(...).((......]].))...)))....))....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).)))))).))..............((....))....))......(..((((....))))............)).....)))))))))).....(.((((((((((..[....)))))))))).<.(.(........).).((((((....(((.((((((((((..(((...(((....)))...)))...((....))...((......)).........)))))))))))))..((.(...((((((.....((((((((((.((((....(((((......)))))....)<)))...(((..(.((........)).).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((...((((.((((((...(((...(((.((((.....)))).)))..)).)...)))))).).)))..))))))).))..(((((((.((......)).)))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((.((((..........((...............(......).......))......)))).)).))..........]]].)....))))))))))...)))))))(..((((((((...))))))))..)....))))))(.(((((((.((......(((((.((....))])))))...)).)))))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((((((...((...((((....(((((.(((..(((((.((((.(....{{.....)))))(((((((.((..((.(((.(((...((.....)).))).))....).))..)))))))))...(((((....)))))....)))))...)))..)))))(..).....))))...))......))))))))))))).))).....((......)).)))).((((......))))..))))..((((....((((((((.((..(....(.......(((((....(.[..).....)))))((((((((...))))))))(...).......(((((((((.>.(...........)...(((((((.....(((.....))).......))))))).]((((.(((..(((((((..(((........((.((....)).))........))))))))..))))).......((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).[..(((((.....>].)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((.(((..(.....)..))).)))))...((.(((........))).))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((....(((...(((((((((((.}}.))))))...)))))...)))..)))))....((....((((.............))))....))..))))..]....)))))))(.(...)....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))...)))))).... The crystal structure large ribosomal subunit (50S) of Deinococcus radiodurans in complex with evernimicin; 23S ribosomal RNA 5jvh Y 120 3.58 RF00001 URS000080E04E_243230 27791159 0003735 0005840 243230 acccccgugcccauagcacuguggaaccaccccaccccaugccgaacugggucgugaaacacagcagcgccaaugauacucggaccgcagggucccggaaaagucggucagcgcgggggu <<<<<<<<<<.....<<.<<<<<....<<<<<<<.............>>>>..>>>...>>>>>..>><<<.......<<.<<<<<....>>>>>.>>.......>>>..>>>>>>>>>> ((((((((((.....((.(.(((....(((.(((...(.....)...)))...)))...))).)..))(((.......((.(((((....))))).)).......)))..)))))))))) The crystal structure large ribosomal subunit (50S) of Deinococcus radiodurans in complex with evernimicin; 5S ribosomal RNA 5k0y N 75 5.8 RF00005 URS0000326EAC_9986 27373335 0030533 0006412 9986 agcagaguggcgcagcggaagcgugcugggcccauaacccagaggucgauggaucgaaaccauccucugcuacca .<.<<<...<<<.........>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>.>>>.>..... (..((((..(((.........))).(((((.......))))).....(((((.......)))))))))..).... m48S late-stage initiation complex, purified from rabbit reticulocytes lysates, displaying eIF2 ternary complex and eIF3 i and g subunits relocated to the intersubunit face; tRNA 5k0y A 1776 5.8 RF01960,RF01959,RF00177 URS0000A7635E_9986 27373335 0003735 0005840 9986 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucgcuccucuccuacuuggauaacugugguaauucuagagcuaauacaugccgacggcgcugacucccuuugugugggaugcgugcauuuaucagaucaaaaccaacccggucagcggcggcggcuuuggugacucuagauaaccucgggccgaucgcagcccuccguggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggucgcagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugagggcccgccccucggcgcccccucgaugugucccgcggggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauucugugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagaugucggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggcccgccggggucggcccacggcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<...[[[[>>>>>[[[.((((((.....{{.........[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[......{{....[[[....................<<.....<<.<<<.....>>>.>>......>>..........<<...<<.<......>.>>...>>..[[..(((((.....<<<<<<<<<<<<.<........>>>>..............)))))......]]...<<<<.<<<......>>>.>>>>....]]]...}}....]]].<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>......}}.......<<<<<<<<<.<<<....>>>.>>.>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..)))))).]]]............{{.......{{...[[[.[[......<<.>>...........<<<<<...............>>>>>.........<<<<<..<.......<<...<.......>.<<<<.......>>>>...>>......>..>>..>>>.......[[....(((((((.....>>>>>>>>>.)))))))...]]....]]....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<..}}>>...>>.....>>>.....<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<......<<<<<<.......<<.<<<........>>>.>>.....>>>>>>.<.<<.<<<..<<<<<<<<<....<<<.<<<<......>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<....<<<..<<<<....>>>>.>>>....>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>...>.>>>>>>>>.....>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>............<<<<<..........>>>>>...........>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<.<<<<<<<<...........>>>>>>>.>...>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((..((....((....((..........))...)){))......(((.......(((.(....((....(((................{...((.....((.(((.....))).))......))..........((...((.(......).))...))..((..(((((.....[[[[[[[[[(((...........)))....(......)..)))))......)).(}((((.(((......))).)))))...)))...))..).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((....(((.}...)))..)))).)...)).).....(((.(((((.(((....))).).))))..)))......((..(...........)..)).........((((([[......((((.....((..]])).......)))).)))))..)))))).)))..{......(.({{...(.(.((...(((..(....(..(.).)........(.(((((..(..........).))))))........(((((..(.......((..((.......))..((.......)).....))......)..))..))).......((.(..(.((.((.....]]]]]]]]].)).)).)..)))....)....(((.((...(...((((..((..((((((((...((........))......))))))))..)).......((....))...))))..)...))..))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((..((..(.((((((.(((........))))))))).)..))....((..}}))...))...}.))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((.(.....(..((.(((........))).))....).).)))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((...(...((((..((((..(.(((.(.(((....)))).))).)..))))..))))..)..(..(((((.....)))))....)...)))....))).))).....).))))).....))))))...)).)))).))).(...((.(((........(.......(((.(.((....)).).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....((((((.(.......).))))))......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..((((......((.((.(((.(((((.........))))).)).)...)).))......))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>........ m48S late-stage initiation complex, purified from rabbit reticulocytes lysates, displaying eIF2 ternary complex and eIF3 i and g subunits relocated to the intersubunit face; 18S ribosomal RNA 5k0y F 30 5.8 27373335 9986 cagacaccauggugcaccugacuccugagg .............................. .............................. m48S late-stage initiation complex, purified from rabbit reticulocytes lysates, displaying eIF2 ternary complex and eIF3 i and g subunits relocated to the intersubunit face; mRNA 5k7c A 47 2.73 27398999 32630 cgugguuagggccacguuaaauaguugcuuaagcccuaagcguugau (((((<<<<<<))))).................>>>>>>........ [[[[[((((((]]]]]................[)))))).]...... The native structure of native pistol ribozyme; RNA 47-MER 5k7c B 11 2.73 27398999 32630 aucaggugcaa ........... ........... The native structure of native pistol ribozyme; DNA/RNA 11-MER 5k7d A 47 2.68 27398999 32630 cgugguuagggccacguuaaauaguugcuuaagcccuaagcguugau (((((<<<<<<))))).................>>>>>>........ [[[[[((((((]]]]]................[)))))).]...... The structure of native pistol ribozyme, bound to Iridium; RNA 47-MER 5k7d B 11 2.68 27398999 32630 aucaggugcaa ........... ........... The structure of native pistol ribozyme, bound to Iridium; DNA/RNA 11-MER 5k7e A 47 3.27 27398999 32630 cgugguuagggccacguuaaauaguugcuuaagcccuaagcguugau (((((<<<<<<))))).................>>>>>>........ [[[[[((((((]]]]]................[)))))).]...... The structure of pistol ribozyme, soaked with Mn2+; RNA 47-MER 5k7e B 11 3.27 27398999 32630 aucaggugcaa ........... ........... The structure of pistol ribozyme, soaked with Mn2+; DNA/RNA 11-MER 5kcr 1A 2897 3.6 RF02540,RF02541 URS0000D56C36_83333 27330110 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccgggagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<...>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<......>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<..<<....>>...>>>>>.>.....>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<..<<<............<<<<<...<<<<....<<<<<<<<....>>>>>>>>.>>>>.............>>>.>>..>>>..>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((........))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((.((...))..))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((((......))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((((((((...((..(..........(.((...((......(.(.((((....)))).).)...)).............)).).)..))...))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).).....((.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..))....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Cryo-EM structure of the Escherichia coli 70S ribosome in complex with antibiotic Avilamycin C, mRNA and P-site tRNA at 3.6A resolution; 23S Ribosomal RNA 5kcr 1B 120 3.6 RF00001 URS0000049E57_83333 27330110 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Cryo-EM structure of the Escherichia coli 70S ribosome in complex with antibiotic Avilamycin C, mRNA and P-site tRNA at 3.6A resolution; 5S Ribosomal RNA 5kcr 1a 1539 3.6 RF00177,RF01959,RF01960 URS000080DDC0_83333 27330110 0003735 0005840 83333 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<......>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<...<....>.>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((((((......)))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((((.......)))))))).....)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...((((.(....(((.((....)).)))...............).)).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....))))))))..)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Cryo-EM structure of the Escherichia coli 70S ribosome in complex with antibiotic Avilamycin C, mRNA and P-site tRNA at 3.6A resolution; 16S Ribosomal RNA 5kcr 1x 87 3.6 RF00005 URS00004630EA_83333 27330110 0030533 0006412 83333 gccgaggugguggaauugguagacacgcuaccuugaggugguagugcccaauagggcuuacggguucaagucccguccucgguacca <<<<<<<..<<<...........>>><<<<<<.......>>>>>><<<......>>>..<<<<<.......>>>>>>>>>>>>.... (((((((..(((......[....))).(((((.......))))).(((......)))..(((((..]....)))))))))))).... Cryo-EM structure of the Escherichia coli 70S ribosome in complex with antibiotic Avilamycin C, mRNA and P-site tRNA at 3.6A resolution; P-site tRNA 5kcs 1A 2900 3.9 RF02540,RF02541 URS0000D56C36_83333 27330110 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccgggagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<<..>>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<..<<<<..>>>>...>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.......<<.........>>..............<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<............>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<......>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<<.<<....>>..>>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..((((((((.((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).((((((((...........)))))))).))...((((((.....(...[..)......))))).)..........(....)....(((((.....((.]...))....)))))...(((..((((......((((((((((.((.(((...(((((......)))))[[......(((.....]])))...)))...)).))))))))))...))))........(((((((...[.......)))))))......(((((].[[[[)))))..)))......))..)))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((((..)))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...).)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((......((...(((.((((...(..((.(..).))...)...)))).)))..)).......)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.((.((..................................(((......)))..)).))...)))..))))).))...........]]].)...))))))))))...)))))))((((..............))))....))))))(..((((...(((......((((((((....))))))))...)))..))))...).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..(((((((((((....{{{...))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..(((........)))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((...((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.((..(((((.((((((((((..((.(............(.((............(((..(......)..)))...................)).)...).))..))))))))))...(((.((((((.....)))))))))....)))))..))..)))))..(((......[)))((((((..........]))))))..((...(((((((...(((((.........))))).....((.[.[[[))....)))))))...((((..((((..{.))))..))))..((....))..))]]].].....(((((((.((..]]]]..)))))))))......}......))))..))))))........((..(.((((((...((.......))...))))))...).))..........(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....(.((.....}.......)).)....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Cryo-EM structure of the Escherichia coli 70S ribosome in complex with antibiotic Evernimycin, mRNA, TetM and P-site tRNA at 3.9A resolution; 23S Ribosomal RNA 5kcs 1B 120 3.9 RF00001 URS0000049E57_83333 27330110 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. (.((((((((.....((((((((....((((((...............)))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))).). Cryo-EM structure of the Escherichia coli 70S ribosome in complex with antibiotic Evernimycin, mRNA, TetM and P-site tRNA at 3.9A resolution; 5S Ribosomal RNA 5kcs 1a 1539 3.9 RF00177,RF01959,RF01960 URS000080DDC0_83333 27330110 0003735 0005840 83333 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<.<<....>>.>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<......>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<.<<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<.<.<<<......>>>.....>>>>>>>>.>..........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>............ .......((((..[..[[..)))).((...(((((..(((((((((....(((.(((..(((..((.((..((((((...(....)...))).)))))..)))))......(((.......((((((..((...(((((((.(.((.....(((((......)))))......)).).....(((....)))....((((((..(......))))))).)))))))..)).)))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((((.......)))))))).....)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))..))..........((([[...(.((((...(((.(((((((.((((((((((......(((.((.....)).)))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((.((((.....)))).)))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]..]((.((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(.(((((..(((((((....))))))).............)))))..)).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.((((.((...((..(((.....)))))....)).))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))..))..(.(..((...((((.(((...(((((((((((....((((((.((((..((....)).))))))))))...)))))))))))...))).))))....))...)..)..(((((((((....)))))))))}........... Cryo-EM structure of the Escherichia coli 70S ribosome in complex with antibiotic Evernimycin, mRNA, TetM and P-site tRNA at 3.9A resolution; 16S Ribosomal RNA 5kcs 1x 73 3.9 RF00005 URS00000FF435_83333 27330110 0030533 0006412 83333 aggcuuguagcucagggagagcgcaccccugauaagggugagnucgguggnucaaguccacucaggccuacca <<<<<<<..<<<<.....>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... .(((.....((((.....)))).(((((.......)))))........((.......))......)))..... Cryo-EM structure of the Escherichia coli 70S ribosome in complex with antibiotic Evernimycin, mRNA, TetM and P-site tRNA at 3.9A resolution; P-site tRNA 5kps 27 1539 3.9 RF00177,RF01959,RF01960 URS000080DDC0_83333 27434674 0003735 0005840 83333 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<<....>>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..........>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>..<<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>>.<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<........<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>......>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((((....))))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..(......))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((..(((((((....)))))))...(......)..))))).))).((.((....((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...))..))))....))))))))..)).)))))))).(...((((((......(((..((...(((....)))...))....)))......))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Structure of RelA bound to ribosome in absence of A/R tRNA (Structure I); 16S ribosomal RNA 5kps 28 2903 3.9 RF02540,RF02541 URS0000A76322_83333 27434674 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugucgaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccgggagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<<..>>>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<.......>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<<..<<<<.......>>>>..>>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<......>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<..............<<...<<........<<<<<<<....>>>>>>>.....>>.............>>.....>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[......(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.((.......))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((.(((.....))).).))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((..........))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((...(((...(((....)))...)))...)))..(((((........)))))]](((((((((((((...((((....((((..(((..(((((((((((....{{{...))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.(((..(..........(..(...(........((...(......)...))......)............)..).)..))).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....((.((((.((..]]]]..)))))).)).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Structure of RelA bound to ribosome in absence of A/R tRNA (Structure I); 23S ribosomal RNA 5kps 29 120 3.9 RF00001 URS00008116C5_83333 27434674 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Structure of RelA bound to ribosome in absence of A/R tRNA (Structure I); 5S ribosomal RNA 5kps 30 18 3.9 27434674 83333 aggagguaaaaauguuca .................. .................. Structure of RelA bound to ribosome in absence of A/R tRNA (Structure I); mRNA 5kps 31 77 3.9 RF00005 URS000041AF00_83333 27434674 0030533 0006412 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Structure of RelA bound to ribosome in absence of A/R tRNA (Structure I); P site tRNAfmet 5kps 32 77 3.9 RF00005 URS00001BBAFC_83333 27434674 0030533 0006412 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaagaucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(((((.......)))))))))))..... Structure of RelA bound to ribosome in absence of A/R tRNA (Structure I); E-site tRNAfMet 5kpv 26 1539 4.1 RF00177,RF01959,RF01960 URS000080DDC0_83333 27434674 0003735 0005840 83333 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<<....>>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<......>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>..<<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>>.<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<.......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>.............>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<<..<<<.....>>>>>.....>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>....>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((((....))))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....))))))).............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Structure of RelA bound to ribosome in presence of A/R tRNA (Structure II); 16S ribosomal RNA 5kpv 27 2903 4.1 RF02540,RF02541 URS0000A76322_83333 27434674 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugucgaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccgggagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<........>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<<<<..>>>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<......<.<<<<<.<<...<<<.........>>>...>>........<<<......>>>..>>>>>.>..>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<..........>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<..<<....>>...>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<..<<<.<<<<<.<<<<<<<<<<<.<<<.............<<.....<<.........<<..........>>......>>...............>>....>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>...>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[......(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...).)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((.((((.....))))..))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((..(......)..)))))....))))))(.(((((...(((......((.(((((....))))).))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((...(((...(((....)))...)))...)))..(((((........)))))]]((((((((((.((...((((....((((..(((..(((((((((((....{{{...))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...)).....)))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((...((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.(((..(..........(..(...((.......(....(......)....)....)).............)..).)..))).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....((.((((.((..]]]]..)))))).)).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Structure of RelA bound to ribosome in presence of A/R tRNA (Structure II); 23S ribosomal RNA 5kpv 28 120 4.1 RF00001 URS00008116C5_83333 27434674 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((.(((((...))))).)).......))...)))))))))). Structure of RelA bound to ribosome in presence of A/R tRNA (Structure II); 5S ribosomal RNA 5kpv 29 20 4.1 27434674 83333 aggagguaaaaauguucaaa .................... .................... Structure of RelA bound to ribosome in presence of A/R tRNA (Structure II); mRNA 5kpv 30 76 4.1 RF00005 URS00005AA258_83333 27434674 0030533 0006412 83333 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<.........>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((........)))).(((((.......))))).....((.((.......)).))))))))).... Structure of RelA bound to ribosome in presence of A/R tRNA (Structure II); A-site tRNAPhe 5kpv 31 77 4.1 RF00005 URS000041AF00_83333 27434674 0030533 0006412 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Structure of RelA bound to ribosome in presence of A/R tRNA (Structure II); P-site tRNAfMet 5kpv 32 77 4.1 RF00005 URS00001BBAFC_83333 27434674 0030533 0006412 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaagaucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(((((.......)))))))))))..... Structure of RelA bound to ribosome in presence of A/R tRNA (Structure II); E-site tRNAfMet 5kpw 26 1539 3.9 RF00177,RF01959,RF01960 URS000080DDC0_83333 27434674 0003735 0005840 83333 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<<....>>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>..<<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>>.<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>.............>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((((....))))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...((((((....))))))..............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Structure of RelA bound to ribosome in presence of A/R tRNA (Structure III); 16S ribosomal RNA 5kpw 27 2903 3.9 RF02540,RF02541 URS0000A76322_83333 27434674 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugucgaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccgggagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<....<.<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>..>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<<..>>>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<<.....>>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<......>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<......>>>>...>>>>>>...>>>...>>>.>........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<<<..............<...<.......>....>.....................>>>...>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((.......((.(((((((((.(((...(((((......)))))[[......(((.....]])))...)))...))))))))).))....))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((((..)))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...).)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((((((.....))))).))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((((......))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((...(((...(((....)))...)))...)))..(((((........)))))]]((((((((((.((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...(((((.((((((.((.....)))))))).)..))))..[))))...))(...((........))....))))))...)))...))))(..).....))))...)).....)))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((...((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((.........((((..((....))...)))).........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((..............((.(............(..(.(......).)..)...................).)).....)).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....((.((((.((..]]]]..)))))).)).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Structure of RelA bound to ribosome in presence of A/R tRNA (Structure III); 23S ribosomal RNA 5kpw 28 120 3.9 RF00001 URS00008116C5_83333 27434674 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((.(((((...))))).)).......))...)))))))))). Structure of RelA bound to ribosome in presence of A/R tRNA (Structure III); 5S ribosomal RNA 5kpw 29 20 3.9 27434674 83333 aggagguaaaaauguucaaa .................... .................... Structure of RelA bound to ribosome in presence of A/R tRNA (Structure III); mRNA 5kpw 30 76 3.9 RF00005 URS00005AA258_83333 27434674 0030533 0006412 83333 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((........)))).(((((.......))))).....(((((.......)))))))))))).... Structure of RelA bound to ribosome in presence of A/R tRNA (Structure III); A-site tRNAPhe 5kpw 31 77 3.9 RF00005 URS000041AF00_83333 27434674 0030533 0006412 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(((((.......)))))))))))..... Structure of RelA bound to ribosome in presence of A/R tRNA (Structure III); P-site tRNAfMet 5kpw 32 77 3.9 RF00005 URS00001BBAFC_83333 27434674 0030533 0006412 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaagaucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((.(......[..).)).(((((.......))))).....(((((..]....)))))))))))..... Structure of RelA bound to ribosome in presence of A/R tRNA (Structure III); E-site tRNAfMet 5kpx 26 1539 3.9 RF00177,RF01959,RF01960 URS000080DDC0_83333 27434674 0003735 0005840 83333 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<<....>>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..........>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>..<<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>>.<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<.<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>.............>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>..>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((((....))))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((........))))......)).).....(((....)))....((((((..(......))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....))))))).............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Structure of RelA bound to ribosome in presence of A/R tRNA (Structure IV); 16S ribosomal RNA 5kpx 27 2903 3.9 RF02540,RF02541 URS0000A76322_83333 27434674 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugucgaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccgggagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<<<<..>>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<<.....>>>>>.>>...>>>>.>>>..>>.>.....>>>>>>>.>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<......<.<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>.>..>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<..<<....>>...>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<................<<<<<<......>>>>>>.......................>..>.>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>.(<<...<<<<<<<...<<<<<<.......>>>>>>.....<<)..(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......((((.(((((.((.(((...(((((......)))))[[......(((.....]])))...)))...)).))))).))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...).)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((.(((.....))).).))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((.(......).))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((...(((...(((....)))...)))...)))..(((((........)))))]](((((((((((((...((((....((((..(((..(((((((((((....{{{...))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((....(((....])))....)))...))))))(...).......(((((((((...((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((..............(...............(.(..(......)..).)......................).....)).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Structure of RelA bound to ribosome in presence of A/R tRNA (Structure IV); 23S ribosomal RNA 5kpx 28 120 3.9 RF00001 URS00008116C5_83333 27434674 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((.(((((...))))).)).......))...)))))))))). Structure of RelA bound to ribosome in presence of A/R tRNA (Structure IV); 5S ribosomal RNA 5kpx 29 20 3.9 27434674 83333 aggagguaaaaauguucaaa .................... .................... Structure of RelA bound to ribosome in presence of A/R tRNA (Structure IV); mRNA 5kpx 30 76 3.9 RF00005 URS00005AA258_83333 27434674 0030533 0006412 83333 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>><<<<<<<.....>>>>>>.>...<<<<<.......>>>>>>>>>>>>.... (((((((..((((........)))).(((((.......))))).....(((((.......)))))))))))).... Structure of RelA bound to ribosome in presence of A/R tRNA (Structure IV); A-site tRNAPhe 5kpx 31 77 3.9 RF00005 URS000041AF00_83333 27434674 0030533 0006412 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Structure of RelA bound to ribosome in presence of A/R tRNA (Structure IV); P-site tRNAfMet 5kpx 32 77 3.9 RF00005 URS00001BBAFC_83333 27434674 0030533 0006412 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaagaucgucgguucaaauccggcccccgcaacca .<<<<<<..<..............>..<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((........[....)).(((((.......))))).....(((((..]....)))))))))))..... Structure of RelA bound to ribosome in presence of A/R tRNA (Structure IV); E-site tRNAfMet 5krg A 15 1.6 28058281 32630 nnnnacuuaagucgg ............... ............... RNA 15mer duplex binding with PZG monomer; RNA (5'-R(*(LCC)P*(LCC)P*(LCC)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*GP*G)-3') 5krg B 15 1.6 28058281 32630 nnnnacuuaagucgg ............... ............... RNA 15mer duplex binding with PZG monomer; RNA (5'-R(*(LCC)P*(LCC)P*(LCC)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*GP*G)-3') 5krg C 15 1.6 28058281 32630 nnnnacuuaagucgg ............... ............... RNA 15mer duplex binding with PZG monomer; RNA (5'-R(*(LCC)P*(LCC)P*(LCC)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*GP*G)-3') 5krg D 15 1.6 28058281 32630 nnnnacuuaagucgg ............... ............... RNA 15mer duplex binding with PZG monomer; RNA (5'-R(*(LCC)P*(LCC)P*(LCC)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*GP*G)-3') 5ktj A 50 2.97 RF02679 URS0000A7633D_256318 28096403 0003824 256318 ncucguuugagcgaguauaaacaguugguuaggcucaaagcggagagcag (((((<<<<<<))))).................>>>>>>........... [[[[[((((((]]]]]................[)))))).]......... Crystal structure of Pistol, a class of self-cleaving ribozyme; Pistol (50-MER) 5ktj B 15 2.97 URS0000A7635F_256318 28096403 256318 ucugcucucguccaa ............... ............... Crystal structure of Pistol, a class of self-cleaving ribozyme; RNA (5'-R(*UP*CP*UP*GP*CP*UP*CP*UP*CP*GP*UP*CP*CP*AP*A)-3') 5ktj C 50 2.97 RF02679 URS0000A7633D_256318 28096403 0003824 256318 ncucguuugagcgaguauaaacaguugguuaggcucaaagcggagagcag .((((<<<<<<))))..................>>>>>>........... .[[[[((((((]]]].................[)))))).]......... Crystal structure of Pistol, a class of self-cleaving ribozyme; Pistol (50-MER) 5ktj D 15 2.97 URS0000A7635F_256318 28096403 256318 ucugcucucguccaa ............... ............... Crystal structure of Pistol, a class of self-cleaving ribozyme; RNA (5'-R(*UP*CP*UP*GP*CP*UP*CP*UP*CP*GP*UP*CP*CP*AP*A)-3') 5kvj A 16 2.261 URS0000A7639D_32630 32630 ccauccucuacaggcg ................ ................ Crystal structure of the 16-mer doublestranded RNA. Northeast Structural Genomics Consortium (NESG) target RNA1; RNA (5'-R(P*CP*CP*AP*UP*CP*CP*UP*CP*UP*AP*CP*AP*GP*GP*CP*G)-3') 5kvj B 16 2.261 URS0000A76395_32630 32630 cgccuguagaggaugg ................ ................ Crystal structure of the 16-mer doublestranded RNA. Northeast Structural Genomics Consortium (NESG) target RNA1; RNA (5'-R(P*CP*GP*CP*CP*UP*GP*UP*AP*GP*AP*GP*GP*AP*UP*GP*G)-3') 5kx9 X 53 2.9 RF00050 URS000080DF4D_851 27485612,26416753 0010181 851 ggaucuucggggcagggugaaauucccgaccggugguauaguccacgaaagcu ..............<<<.......>>>.....<<<<......>>>>....... ..............(((.......))).....((((......))))....... Selective Small Molecule Inhibition of the FMN Riboswitch; FMN Riboswitch 5kx9 Y 56 2.9 RF00050 URS000080E20B_851 27485612,26416753 0010181 851 gcuuugauuuggugaaauuccaaaaccgacaguagagucuggaugagagaagauuc .......<<<<<.......>>>>>.....<<<......>>>............... .......(((((.......))))).....(((......)))............... Selective Small Molecule Inhibition of the FMN Riboswitch; FMN Riboswitch 5l00 A 15 1.25 28058281 32630 nnnnacuuaagucgg ............... ............... Self-complimentary RNA 15mer binding with GMP monomers; RNA (5'-R(*(LCC)P*(LCC)P*(LCC)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*GP*G)-3') 5l00 B 15 1.25 28058281 32630 nnnnacuuaagucgg ............... ............... Self-complimentary RNA 15mer binding with GMP monomers; RNA (5'-R(*(LCC)P*(LCC)P*(LCC)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*GP*G)-3') 5l00 C 15 1.25 28058281 32630 nnnnacuuaagucgg ............... ............... Self-complimentary RNA 15mer binding with GMP monomers; RNA (5'-R(*(LCC)P*(LCC)P*(LCC)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*GP*G)-3') 5l00 D 15 1.25 28058281 32630 nnnnacuuaagucgg ............... ............... Self-complimentary RNA 15mer binding with GMP monomers; RNA (5'-R(*(LCC)P*(LCC)P*(LCC)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*GP*G)-3') 5l3p A 2890 3.7 RF02540,RF02541 URS0000A76322_83333 27226493 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccgggagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagugcgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<<..>>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<<..>>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.......<<.........>>..............<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<............>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<......>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<..<<....>>...>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<.................<<....>>..............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..((((((((.((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).)..........(....)....(((((.....((.]...))....)))))...(((..((((......((((((((((.((.(((...(((((......)))))[[......(((.....]])))...)))...)).))))))))))...))))........(((((((...[.......)))))))......(((((].[[[[)))))..)))......))..)))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((((..)))))))..)))).[.(.(........).).((((((....((.((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))).))..((.(...((((((.....((((((((((.((((...((((((......))))))...).)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(..((((..))))...)...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.((.((..................................(((......)))..)).))...)))..))))).))...........]]].)...))))))))))...)))))))(((((............)))))....))))))(..((((...(((......((((((((....))))))))...)))..))))...).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..(((((((((((....{{{...))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..(((........)))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((...((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((...((.(............(.((..............(..(......)).............)).)...).))...)))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))..((...(((((((...(((((.........))))).....((.[.[[[))....)))))))...((((..((((..{.))))..))))..((....))..))]]].].....(((((((.((..]]]]..)))))))))......}......))))..))))))........((..(.((((((...((.......))...))))))...).))..........(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....(.((.....}.......)).)....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Cryo-EM structure of stringent response factor RelA bound to ErmCL-stalled ribosome complex; 23S ribosomal RNA 5l3p B 120 3.7 RF00001 URS00008116C5_83333 27226493 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((.(((((((.....((((((((....((((((...............)))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))).)). Cryo-EM structure of stringent response factor RelA bound to ErmCL-stalled ribosome complex; 5S ribosomal RNA 5l3p a 1539 3.7 RF00177,RF01959,RF01960 URS000080DDC0_83333 27226493 0003735 0005840 83333 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<.<<....>>.>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<......>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<.<<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<.<.<<<......>>>.....>>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<<..<<<.....>>>>>.....>>>>>>.....<<<<<.....>>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>........<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>..........<<<<<<<<<....>>>>>>>>>............ .......((((..[..[[..)))).((...(((((..(((((((((....(((.(((..(((..((.((..((((((............))).)))))..)))))......(((.......((((((..((...(((((((.(.((.....(((((......)))))......)).).....(((....)))....((((((..(......))))))).)))))))..)).)))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((((.......)))))))).....)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))..))..........((([[...(.((((...(((.(((((((.((((((((((......(((.((.....)).)))....))))))))..)))))))))...((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))...)))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((.((((.....)))).)))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]..]((.((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((..(((((((....))))))).............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.((((......((..(((.....))))).......))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....))))))))..)).)))))))).(...((((((......(((..((...(((....)))...))....)))......))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))..))..(.(..((...((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))....))...)..)..(((((((((....)))))))))}........... Cryo-EM structure of stringent response factor RelA bound to ErmCL-stalled ribosome complex; 16S ribosomal RNA 5l3p x 77 3.7 RF00005 URS00001BBAFC_83333 27226493 0030533 0006412 83333 cgcggggnggagcagccuggnagcucgucgggcucauaacccgaagaucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Cryo-EM structure of stringent response factor RelA bound to ErmCL-stalled ribosome complex; P-site tRNA 5l3p y 73 3.7 RF00005 URS0000A76379_83333 27226493 0030533 0006412 83333 gcugauauagcucagnnggnagagcgcacccuuggugagggugagnucggcagnucgaaucugccuaucagca .<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<.........>>>>>>>>>>.. .((((.(..(((......[...))).(((((.......))))).....(((....]......)))).)))).. Cryo-EM structure of stringent response factor RelA bound to ErmCL-stalled ribosome complex; deacylated A/R-tRNA 5li0 a 1547 3.8 RF00177,RF01959,RF01960 URS0000B21DF7_93061 27906650 0003735 0005840 93061 ggagaguuugauccuggcucaggaugaacgcuggcggcgugccuaauacaugcaagucgagcgaacggacgagaagcuugcuucucugauguuagcggcggacgggugaguaacacguggauaaccuaccuauaagacugggauaacuucgggaaaccguagcuaauaccggauaauauuuugaaccgcaugguucaaaagugaaagacggucuugcugucacuuauagauggauccgcgcugcauuagcuaguugguaagguaacggcuuaccaaggcaacgaugcauagccgaccugagagggugaucggccacacuggaacugagacacgguccagacuccuacgggaggcagcaguagggaaucuuccgcaaugggcgaaagccugacggagcaacgccgcgugagugaugaaggucuucggaucguaaaacucuguuauuagggaagaacauauguguaaguaacugugcacaucuugacgguaccuaaucagaaagccacggcuaacuacgugccagcagccgcgguaauacguagguggcaagcguuauccggaauuauugggcguaaagcgcgcguaggcgguuuuuuaagucugaugugaaagcccacggcucaaccguggagggucauuggaaacuggaaaacuugagugcagaagaggaaaguggaauuccauguguagcggugaaaugcgcagagauauggaggaacaccaguggcgaaggcgacuuucuggucuguaacugacgcugaugugcgaaagcguggggaucaaacaggauuagauacccugguaguccacgccguaaacgaugagugcuaaguguuaggggguuucccgccccuuagugcugcagcuaacgcauuaagcacuccgccuggggaguacgaccgcaagguugaaacucaaaggaauugacggggacccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaaaucuugacauccuuugacaacucuagagauagagccuuccccuucgggggacaaagugacagguggugcaugguugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuuaagcuuaguugccaucauuaaguugggcacucuaaguugacugccggugacaaaccggaggaagguggggaugacgucaaaucaucaugccccuuaugauuugggcuacacacgugcuacaauggacaauacaaagggcagcgaaaccgcgaggucaagcaaaucccauaaaguuguucucaguucggauuguagucugcaacucgacuacaugaagcuggaaucgcuaguaaucguagaucagcaugcuacggugaauacguucccgggucuuguacacaccgcccgucacaccacgagaguuuguaacacccgaagccgguggaguaaccuuuuaggagcuagccgucgaaggugggacaaaugauuggggugaagucguaacaagguagccguaucggaaggugcggcuggaucaccuccuu ...<<<<....((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<<<....<<<........>>>....>>>>.>>>>>......<<........<<<<<<<..<<...<<<<<<<.<<<<.....<<.<<<....>>>.>>......>>>>......<<<<<<<<<....>>>>>>>>>......<<<<<<...>>>>>>.>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<<<<<<<............<...<.......>..>.............>>>>>>...>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<<..<<<.<<<<<<<.<<<<<<<<<.......<<<<<<.....>>>>>>.....>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>..>>>>>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<<.....>>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..))))..<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<........<<........>>..........<<<<<<<......<<<<.......<<<<<....>>>>>.....<<......>>.....>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<......>>>>>...>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>......>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<..<<<<....<.<<<<..<<<..<<<...>>>.>>>.>>>>.>...>>>>..>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............. ...((((...[[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((..((.....(((........))).....))..)))))......(((.......(((((((..((...(((((((.((((.....((.(((....))).))......))))......(((((((((....)))))))))......(((.(.....).))).)))))))..))))))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....((((((................(.......)................))))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))...).)))))))..)))))))))..(....((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).......))))...))))....((((((....(...((((.........))))...).))))))..........((((((..((((((((((((.......))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((.......(........)...........(((((((..(...(((((......(((((....)))))......(......)....).)).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..((......)))))...)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((..((((....(.((((..(((..(((...))).))).)))).)...))))..))))))..))).))))..).))...)..)..((((((.((....)).))))))............. 70S ribosome from Staphylococcus aureus; 16S ribosomal RNA 5li0 A 2914 3.8 RF02540,RF02541,RF00002 URS0000B21DE4_93061 27906650 0003735 0005840 93061 uuaaguuauuaagggcgcacgguggaugccuuggcacuagaagccgaugaaggacguuacuaacgacgauaugcuuuggggagcuguaaguaagcuuugauccagagauuuccgaauggggaaacccagcaugaguuaugucauguuaucgauaugugaauacauagcauaucagaaggcacacccggagaacugaaacaucuuaguacccggaggaagagaaagaaaauucgauucccuuaguagcggcgagcgaaaugggaagagcccaaaccaacaagcuugcuuguugggguuguaggacacucuauacggaguuacaaaggacgacauuagacgaaucaucuggaaagaugaaucaaagaagguaauaauccuguagucgaaaauguugucucucuugaguggauccugaguacgacggagcacgugaaauuccgucggaaucugggaggaccaucuccuaaggcuaaauacucucuagugaccgauagugaaccaguaccgugagggaaaggugaaaagcaccccggaaggggagugaaauagaaccugaaaccgugugcuuacaaguagucagagcccguuaaugggugauggcgugccuuuuguagaaugaaccggcgaguuacgauuugaugcaagguuaagcaguaaauguggagccguagcgaaagcgagucugaauagggcguuuaguauuuggucguagacccgaaaccaggugaucuacccuuggucagguugaaguucagguaacacugaauggaggaccgaaccgacuuacguugaaaagugagcggaugaacugaggguagcggagaaauuccaaucgaaccuggagauagcugguucucuccgaaauagcuuuagggcuagccucaagugaugauuauuggagguagagcacuguuuggacgaggggccccucggguaccgaauucagacaaacuccgaaugccaauuaauuuaacuugggagucagaacaugggugauaagguccguguucgaaagggaaacagcccagaccaccagcuaaggucccaaaauauauguuaaguggaaaaggauguggcguugcccagacaacuaggauguuggcuuagaagcagccaucauuuaaagagugcguaauagcucacuagucgagugacacugcgccgaaaauguaccggggcuaaacauauuaccgaagcuguggauuguccuuuggacaaugguaggagagcguucuaagggcguugaagcaugaucguaaggacauguggagcgcuuagaagugagaaugccggugugagucgcgaaagacgggugagaaucccguccaccgauugacuaagguuuccagaggaaggcucguccgcucuggguuagucggguccuaagcugaggccgacaggcguaggcgauggauaacagguugauauuccuguaccaccuauaaucguuuuaaucgauggggggacgcaguaggauaggcgaagcgugcgauuggauugcacgucuaagcaguaaggcugaguauuaggcaaauccgguacucguuaaggcugagcugugauggggagaagacauugagucuucgagucguugauuucacacugccgagaaaagccucuagauagaaaauaggugcccguaccgcaaaccgacacagguagucaagaugagaauucuaaggugagcgagcgaacucucguuaaggaacucggcaaaaugaccccguaacuucgggagaaggggugcucuuuaggguuaacgcccagaagagccgcagugaauaggcccaagcgacuguuuaucaaaaacacaggucucugcuaaaccguaaggugauguauaggggcugacgccugcccggugcuggaagguuaagaggagugguuagcuucugcgaagcuacgaaucgaagccccaguaaacggcggccguacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgacccgcacgaaaggcguaacgauuugggcacugucucaacgagagacucggugaaaucauaguaccugugaagaugcagguuacccgcgacaggacggaaagaccccguggagcuuuacuguagccugauauugaaauucggcacagcuuguacaggauagguaggagccuuugaaacgugagcgcuagcuuacguggaggcgcuggugggauacuacccuagcuguguuggcuuucuaacccgcaccacuuaucguggugggagacagugucaggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcucaaagguucccucagaaugguuggaaaucauucauagaguguaaaggcauaagggagcuugacugcgagaccuacaagucgagcagggucgaaagacggacuuagugauccggugguuccgcauggaagggccaucgcucaacggauaaaagcuaccccggggauaacaggcuuaucucccccaagaguucacaucgacggggagguuuggcaccucgaugucggcucaucgcauccuggggcuguagucggucccaaggguugggcuguucgcccauuaaagcgguacgcgagcuggguucagaacgucgugagacaguucggucccuauccgucgugggcguaggaaauuugagaggagcuguccuuaguacgagaggaccgggauggacauaccucugguguaccaguugucgugccaacggcauagcuggguagcuauguguggacgggauaagugcugaaagcaucuaagcaugaagccccccucaagaugagauuucccaacuucgguuauaagaucccucaaagaugaugagguuaauagguucgagguggaagcauggugacauguggagcugacgaauacuaaucgaucgaagacuuaau <<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<<<<<<<<.........>>>>>>>.>>.>>....<<<<<......<<....>>.......>>>>.>...[.....<<....>>..<<<<<......<<.....>>.....>>>>>..(((....<<<<<<<<....>>>>>>>>......<<<<<<<<<.....<............<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>.....>.>>>>>..>>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))....].]].>>>>>>>.]]...............<<....>>....]].........<<<<....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<......>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<.<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>.>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<...<<<<<<<<<.....<<<...<<<<<<<....<<..<<<...>>>..>>....>>>>>>>..>>.>.....>>>>.>>>>>..>>>>>>>.>>..<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<.<<<<........<<<<<.<<...<<<.........>>>...>>......................>>>>>....>>>>.>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<...>>>>>>>....>>>>>>..<<<<<<<.<<......<<<<<.<<....>>.>>>>>...>>.>>>>>>>........>>>>>><.....<<<....<<<<<<.......>>>>>><<<<....<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<...........<<...<<<<....<<<<...<<...<....<.<<....[.[....>>.>.<....<<<<...<<<.<<<<<<..<<.....>>.>>>>>>......>>>...>>>>.....>..........................>....>>...>>>>.........>>>>..>>......>>>>>>>>>>>..>>.....<<......>>.>>>>.<<<.......>>>..>>>>..<<<<....<<<<<<<<..<...............<<<<<.....<..>......>>>>><<<<<<<.<<<<....>>>>.>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<..<<....>>...>>>>>...>>...>>>>>>>>..>>>>><<<<<<......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>.....>..>>>>>>>>.>>>>>>>....>.(...<<<<<.......)>>>>>..<<<<<<<<.(((.((......<<<<.((<<<<..<<<<<.<<<<<<<<<.<<<<.<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>.>>>>....<<.<<<<<<.....>>>>>>>>.....>>>>>>>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.((.((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))))......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..))>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....))..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.].]>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<....>>>....<<<<<<<<.........>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>. ((((((......((((((((((.....(((..(((((((((((((......((((((.[[..[[[)))...].((((((...(((]]..]].)))......))))))...)))....(((....)))(((((((......)))))))..((((((((.........))))))).)..))....(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...((((((.(....).))))))....{.(((((((((.................(((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))).).....)))))..)))))....(((((((...[.......)))))))....}.(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((..((((..{...))))..)))).[.(.(..[.....).).((((((..(.(((((((.(((((..(((...(((.....)))...)))...((....))...(((.....)))......))))).)))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...).)))...(((.(((((........))))))))..).))))))))).(.(((....[)))...).]))))))......).)))..(((((....(((((....))))).((((((((...(((((((((.....(((...((((((((...((...((...))...))...))))))))..)).).....)))).)))))..))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((.(((((.....<.((....(((...((.........))...))).........................))...))))).)))).))...........]]].)...))))))))))...)))))))(((((((...)))))))....))))).(.(((((((.((......(((((.((....))})))))...)).)))))))..).....))))))(......((....((((((.......))))))((((...[(((...((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]]((((((.............(...((((....((((...((..................{..........(...((((....((.(((((((.((.....)))))))))......))....))))....)................................))...))))(..).....))))..)........)))))))))).))).....((......))..))).(((.......)))..))))].((((....((((((((.((.......(........((((....(.[..).....)))).(((((((.((((....)))).)))))))(...).......((((((..(...((.........))...(((((((.....(((....))).......))))))).]((((.(((..(((((((..(((...((...(((((..((....))...)))))...))...))))))))..)))))(.(((........))).)........((..........(((((.......)))))..)..)....))))...)...)))))).)...)).)))))))).)))))).....)).{..(((((..]..]}.)))))..(((.((((.(((.((......((((.((((((..(((((.(((((((((.((((..((((((((((.([........(((((..(((......((((((((...]))))))))...)))............)))))).))))))))))..))))....((.((((((.....)))))))).....)))))))))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.((..(.........)..))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..)))..((((.....))))......)))))..)...))).).....(((((((....))).))))....))..))))))).)))[...(((((((...((((..((.((((.....(....)....)))).)).((.((...((((...(((((((((((.}..))))))..)))))...)))).)).))...(((....((((.....>.......))))....))).))))..]....)))))))((((....)))....(((((((((.......)))))....((((((((.(((.....((((....))))....)))..))))).)))...))))...))))))). 70S ribosome from Staphylococcus aureus; 23S ribosomal RNA 5li0 B 114 3.8 RF00001 URS00003DF33D_93061 27906650 0003735 0005840 93061 ucuggugacuauagcaaggaggucacaccuguucccaugccgaacacagaaguuaaggucuuuagcgacgaugguagccaacuuacguuccgcuagaguagaacguugccaggc .<<.<..<.....<<<<<<<......<<<<<...............>>>..>>.....>>>>>.>><....<<...<.<............>.>....>>...>..>..>.>>. .(..(..(.....(.((.((......((((((...(.....)...))))..)).....)).))..)............(............)..............)..)..). 70S ribosome from Staphylococcus aureus; 5S ribosomal RNA 5lj3 U 141 3.8 RF00020 URS0000514318_4932 27459055 0000244,0000353 0005682,0046540 4932 cagcuuuacagaucaauggcggagggaggucaacaucaagaacugugggcgccuauagaacuuauaacgaacaugguucuugccuuuuaccagaaccauccggguguugucuccauagaaacagguaaagcuguauuuuuu <<<<<<<<<.......<.......<<<<<.<<<<<<<.....<<<<<<<..>>>>>>>..............<<<<<<<<...........>>>>>>>>...>>>>>>>>>>>>......>...>>>>>>>>>........ (((((((((.......(.......(((((.(((((((.....(((((((()))))))).........((...((((((((.(.......).)))))))).))))))))))))))......)...)))))))))........ Structure of the core of the yeast spliceosome immediately after branching; U5 snRNA (small nuclear RNA) 5lj3 E 16 3.8 URS0000B21E0A_4932 27459055 4932 uaagugaucuagaaag ................ ................ Structure of the core of the yeast spliceosome immediately after branching; Exon 1 (5' exon) of UBC4 pre-mRNA 5lj3 I 33 3.8 27459055 4932 guaugucuaaaugcucuuauuuacuaacaaaau ................................. ................................. Structure of the core of the yeast spliceosome immediately after branching; Intron of UBC4 pre-mRNA 5lj3 Z 171 3.8 RF00004 URS000023C730_4932 27459055 0045131 0000348 0005686 4932 gaaucucuuugccuuuuggcuuagaucaaguguaguaucuguucuuguaacaacugaaaugaccuaggcucauuguuacaauacacauuuuuuggggacgggaagaggagacgucgcgacccucgcagagucguucuugacuuggucgcuugauguuucuucuucccguuc .............................................<<<<<<<<......<<<<<<>>>.>>>>>>>>>>>...............<<<<<<<<<<<.<<<<<<<<<<<<.<<.....<<<<<<....>>>>>>>>>>>>..>>>>>>>>.>>>>>>>>>>> .............................................((((((((......(((((())).)))))))))))...............(((((((((((.((((((((((((.((......(((((....))))).))))))..)))))))).))))))))))) Structure of the core of the yeast spliceosome immediately after branching; U2 snRNA (small nuclear RNA) 5lj3 V 97 3.8 RF00026 URS00006184A9_4932 27459055 0030621 0000244,0000353 0005688,0046540 4932 guucgcgaagcuucguggacauuuggucaauuugaaacaauacagagaugaucagcaguuccccugcauaaggaugaaccguuuuacaaagagauuu <<<<<<<<<..>>>>>>>>>.....................................<<<..<<<.....>>>...>>>.................. (((((((((()))))))))).....................................(((.((((.....)))..)))).................. Structure of the core of the yeast spliceosome immediately after branching; U6 snRNA (small nuclear RNA) 5lj5 U 141 10.0 RF00020 URS0000514318_4932 27459055 0000244,0000353 0005682,0046540 4932 cagcuuuacagaucaauggcggagggaggucaacaucaagaacugugggcgccuauagaacuuauaacgaacaugguucuugccuuuuaccagaaccauccggguguugucuccauagaaacagguaaagcuguauuuuuu <<<<<<<<<.......<.......<<<<<.<<<<<<<.....<<<<<<<..>>>>>>>..............<<<<<<<<...........>>>>>>>>...>>>>>>>>>>>>......>...>>>>>>>>>........ (((((((((.......(.......(((((.(((((((.....(((((((()))))))).........((...((((((((.(.......).)))))))).))))))))))))))......)...)))))))))........ Overall structure of the yeast spliceosome immediately after branching.; U5 snRNA (small nuclear RNA) 5lj5 E 16 10.0 URS0000B21E0A_4932 27459055 4932 uaagugaucuagaaag ................ ................ Overall structure of the yeast spliceosome immediately after branching.; Exon 1 (5' exon) of UBC4 pre-mRNA 5lj5 I 33 10.0 27459055 4932 guaugucuaaaugcucuuauuuacuaacaaaau ................................. ................................. Overall structure of the yeast spliceosome immediately after branching.; Intron of UBC4 pre-mRNA 5lj5 Z 171 10.0 RF00004 URS000023C730_4932 27459055 0045131 0000348 0005686 4932 gaaucucuuugccuuuuggcuuagaucaaguguaguaucuguucuuguaacaacugaaaugaccuaggcucauuguuacaauacacauuuuuuggggacgggaagaggagacgucgcgacccucgcagagucguucuugacuuggucgcuugauguuucuucuucccguuc .............................................<<<<<<<<......<<<<<<>>>.>>>>>>>>>>>...............<<<<<<<<<<<.<<<<<<<<<<<<.<<.....<<<<<<....>>>>>>>>>>>>..>>>>>>>>.>>>>>>>>>>> .............................................((((((((......(((((())).)))))))))))...............(((((((((((.((((((((((((.((......(((((....))))).))))))..)))))))).))))))))))) Overall structure of the yeast spliceosome immediately after branching.; U2 snRNA (small nuclear RNA) 5lj5 V 97 10.0 RF00026 URS00006184A9_4932 27459055 0030621 0000244,0000353 0005688,0046540 4932 guucgcgaagcuucguggacauuuggucaauuugaaacaauacagagaugaucagcaguuccccugcauaaggaugaaccguuuuacaaagagauuu <<<<<<<<<..>>>>>>>>>.....................................<<<..<<<.....>>>...>>>.................. (((((((((()))))))))).....................................(((.((((.....)))..)))).................. Overall structure of the yeast spliceosome immediately after branching.; U6 snRNA (small nuclear RNA) 5lks L5 3776 3.6 RF02543,RF02540 URS000086853A_9606 27665925,25901680 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcggcccggcggaucuuucccgcgcgggggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucggccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcgcucuccccccucccggcgccgccggggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccgggggaggggccacgcgcgcgucccccgaagagggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcacacgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcgugagccgggcguggaauggagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagcggcgggggcggcgcgcgcgcgcgcccgcccccggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcugggucggucgucggccggcgccuagcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacaugagagguguagaauaagugggaggcccccggcgcccccccgguguccccgcgaggggcccggggcgggguccgccggcccugcgggccgccggugaaauaccacuacucugaucguuuuuucacugacccggugaggcgggggggcgagccccgaggggcucucgcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccggucccccgcgggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcacgccguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu ..........................<<<<<.....<......>......>>>>>...........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>>..<<<<<<<<<....<<<<<.<<........<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>...>>.>>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..(((((.>>>>>..>>>..................................<<....>>...............<<<......>>>..................................<<<<<<<<..<<<.......<<<<<<<.<<<.....<<<<<<<<<<<....<<.<..<..<.......<<<<<.<<<..<<......>>>>>>>>>>..>...>.>....>>..>>>>>>>>>>>......>>>.>>>.>>>>...<<<<<<<..<<<<<<<<<<.<<<........<.<<.<.<<<.........<<<..>>>..........>>>.>.>>>...........>>>...>>>>>>>>>>...........................<<<<<.................>>>>>.....<<..<<...<<<<<<<<<..<<<<<.<<<<<<..............>>>>>>.>>>>.>..>>>>>>>.>>.....>>....>>...........<<<<.<......>.>.>>>.....................>>.>>>>>....>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<..........>>>>>..<<<<<...<<<..<<<..[[[[.....>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<..<<........>>.>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<............<<<<<<<<....<<<....<<.....<<<.......................>>>.....>>..>.>>....>>>>>>...<<<<<<<<<........>>>>>>>>>...>>...>>>>>>>.>>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<..........<<..................................................>>......>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<..............]].]]....................................................>>>>>>>>>....>>>>>>...<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<...<<<...>>>...>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<.....<<<<<<......>>>>>>...<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<<<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>.>.>>>>>>>>>>>>.........>>>>>>>..>.............>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<........................>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<......<.....<<<<....>>>>.....>...>>>>..>>>>><<<............>>>.........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>.....<<<<..<<<.<<......<<<<.<.<<<<..<<<<<.<<<<<<<<<.<<<<<<<<........<......................................................................................................>........>>>>>>>>...<<<<<.....<<<<.........<<...>>.....................<<<<<<<<<<<.....>>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.((.((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))).....<<<<<<<..<<<...))))).>>>>>>>>>>.........>>>>...>>>>>.......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>......<<<<<<....<<<....<<<<<.................>>>>>..<<<<....<<<<....<<.<<<<<<.]]]..>>>>..>>.>>...>>>>...>>>><<<.....<<<<<...........>>>>>.....>>>.>>>.....>>>>>>.....<<<<<<<.............<<.........<<<<<..<..<..>.>..>>>>>........>>....<<...<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>...>>.....................>>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<....<<<<<......>>>>>...>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(.(((......(...[..).......)))..)....................((.(......((.]...))......)))...((((...(((...(.((((.(((.....))).)).)).).....)))....((((..(.(....((.(..(.........((((((((..(...((......))..)....(((...).[.......))..]...).)))))))....)..).))...).)..))))..)....(((((((........))))))).....(.(((....{{.{))).)..)))..................................((....))............(..((((....))))............).....................((((((((..(((........(((..(...(......(((((((((.....(.(.........(....((.((.(................))).)).).......)....)...))))))))).......)....)..)))....(((..(.(.(((..((((..(.(..........(.((.((.....(..(.(((..))).)..)......)).)).)............).)....))))..)))......................(....(.........................).....((....(..((.(((.....(.(((.(((((.(.............)))))).))).)......)))..).)....).....).)........................................)........).)...)))....)))...)))))))).{.(((........)).)(((.((....(((((.(((..((..(((....((..........))......)))...((....))....((((..........))).)..(((((...((...(((..[..[.....)))...))....)))))..(.(..((..((((......)))).).).)..).....))..))).))))).....(...((((((.....((..(..((..((((.....(((((....)))).)....){)))....((..(..((........)).).)).....))..)..)).(.((.......))...)..))))))......)......(((((......(((....)))..((.(((.(((............(..((.((.....(.....((...(.((........(......).........)).)...))...)......)).))......(((((((........)))))))......)...))).)))..))..((.(.(((((.....))))).).))....(((......))).....((.((...(.([.[...(.(.(((((......(..........(((.(((((.((((...........(.................................................)......))).)))))))))..........].].)....)))))))).)...)).))..((.(((.(((...............]..]....................................................)))))).))....)))))...(((..((((..(.......(.(.((((....))))).)....).))))..)).)......)).)))((......(.......((((.......))))...(((......(((..((...((..(....((.....))..)..))......(.(.((....(....((......))..........((.(..(....(....)...)..)))......).....))...(((((........)))))..((((....(.(.....(((............)))...((.(...)))...(....(((((...((.(((..((...((((((((....[[[....))))....(..((.((((.((((.....((.......)).....))))))))..))..).....((.((.(.......).)).)))))).....))..))).))(...)....)))))....).............).).)))).).)..)).....((......)).)))..((((.....))))..)))....((((.....(((((((.((..(....(.......((((.....(.[..)......))))((.((((.((((............................)))..).)))).))(...).......(((((((((.}.((.........)).....(..((....(((.......)))......))..)...].(((.(((..(.((.(............((.(.....))).........).))...))))...........................((..........((((.........))))..)..)....)))....)).))))))).)..))).)))))))..))))).....)).[..(((((.....}].))))).....((((...((.((......((((.(..(((...(((..(((.(((((...(.(..(........................................................................................................................)...)).....((.((.....((((.....(..............)................(((((((.((.......)).)))))))..))))..)).))....))))).)))...)))...(............)(.((((...........)))).)(.((...(..(.((....((.((.......)).))......((...[[[))....)).)...)(..((..((.(.......).))..)).)(((....))).))]]].......(.((((..(((..}.}}...))))))).)....).....)).)...)))))..........(.(.((((.(...((.......))...).))))...))............((((.(.((....(...((((........)))).....)..((.(.....).))........).)..)...))).).....(..(.((....))..)..)....))..).).)))).......(((((.(..(((..(.(((((......(....).....))))).)((((....(.((....((.(((((((]]].)))))..)).))...)).)...))))..(.....((((.............)))).....)...)))...).))))).......((.........((......((..........((((.............)))).........).).......((((.........(.(((((......))))).).......))))...................))........)).(((((.(..(.......)..).......(((((((.((.....((((....(((((......)))))...))))....))....)))).))).....))))).. Structure-function insights reveal the human ribosome as a cancer target for antibiotics; 28S ribosomal RNA 5lks L7 120 3.6 RF00001 URS00000F9D45_9606 27665925,25901680 0003735 0005840 9606 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. ((((((.((....((((((((.....((...(...(....)...).....))....)))))).))((((((......(..((..((....)).))..).....)))))))).)))))).. Structure-function insights reveal the human ribosome as a cancer target for antibiotics; 5S ribosomal RNA 5lks L8 156 3.6 RF00002 URS0000005270_9606 27665925,25901680 0003735 0005840 9606 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<.<<.....>>>.....(.<<<......>>.............>>>..)...>>>....<<<..>>><<<<<<<<.......>>>>>>>>.................... .........................................(((((..[[......)).......(((......]].............)))......)))....(......)(((((((.(......)))))))).................... Structure-function insights reveal the human ribosome as a cancer target for antibiotics; 5.8S ribosomal RNA 5lks S2 1742 3.6 RF01960,RF01959,RF00177 URS0000868520_9606 27665925,25901680 0003735 0005840 9606 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucgcuccucucccacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgccccccguggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuccgcgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcgggcguccccgccgccucucggccggggcccgaagcauuuacuuugaaaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggucggcccacggcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<....((((.>>>><<<.<<<<<<...<.<<..<......<<<.<<<...<....<<.....<..........>....>>.>.......<<........<<<.<....<<....<<<....................<<....<<<..<.......>..>>.>....>>.........<<<<....<<<<......>>>>....>>>><...<<<<<.............>>>>>........>..<<<<.<<<<......>>>>>>>>....>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>..>>>..>...>>.>.....<<.<.<<<<............>>.>>.>..>>..........<...........>.............<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>.>>>...........<((.....<.<<...<<<...................................................<<<<<<.<.......<<...<.......>.<<<.........>>>...>>......>.>>>..>>>...............<<<..................>.>>.................<<<<<<......<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>.....>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>...<<<......<<<......>>>....>>>..))))..<<<<<.<<<<<<<..<<..<<<<...<<<.<<<<........<<........>>..........<<<<<.......<.<<........<...<<........>>...>......>>.>....<..<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<.<<...<.................................>...>>.>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>.>.......>>>>>......>>>>.>>>.....<<.<<<................<<<.<<<<....>>>>.>>>..............>>>.>>............<<<<<..........>>>>>............>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<.<<<....<.....................>......>>>.>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>.........<<<<<<<<<....>>>>>>>>>......... ...((((..[[[[[..))))(((.((.(((.....((..((......((..(....(....((.....(..........)....))[).......((........(((.(.(...(....(((.(..................((......(...(.....)...).......)).........((.......((........).)......)).....(((...............)))............(.((..((........)).)).).)..)))...).).).))).(((....(.(....(((((((.........)))))))).)......)))...(((.((((....))))....))).)).((.(((..........))).)).(.((....)).)....).))..).....(.(((....(...].....)..)))).)...)).......((....(((............)).).....))....................................(((((.[.......(.(.....((...])).......).)..)))))..))).)).)))...........([[...(.(.((...(((..(................................................((((((.(........(..((.......)).(((.......)).)...).......).)))..)))..................(.................)..............)....(((..(...(....(((..((..(((((..(...((........))......)..)))))..))..................)))...)...)...))..))))...)).)....(((.((........(..(.........)..).....)).)))......{...((.....(((....(((.((.(((........))))).)))....)))....(..]])............))))....((......((........))....))....]]].]](.((.((.(((...((..(((.....((.(...((.......(........)...........((.(.........................(........)...................((.((....(..((((.....(((.(((((....)))..(.(........))...)).))).....(....(...((((.........................................))))..).....(((((.....))))).........)......)).))......)..))).).......).))...))....).).).(...((.((......................(((....)))....................)).))......(......(.((..........))..).....)..)....))).....(((((((.........)))))))......))....))).))))..)........(..(..(.((.((.....(((((((.(((..(.((.((.....(((((...........................).).))).....)).)).)..))).)))))))....)).)).)...)..).........((((((((......))))))))}........ Structure-function insights reveal the human ribosome as a cancer target for antibiotics; 18S ribosomal RNA 5lmn A 1514 3.55 RF00177,RF01959,RF01960 URS000080E226_300852 27662086 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggauaccuccuuu ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<<<<<<<<.......>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<<....>>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<.<..<<<<<<<.<..<<<......>>>.....>.>>>>>>>...>.......<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<.<..<<<<<<<....>>>>>>>...<<<<....>>>>...>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............. ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((.(((.(.....).))).)))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((......((((((.(...((((((....))))))....((((....))))...)))))))..((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...(...(((.....)))).....)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}............ Structure of bacterial 30S-IF1-IF3-mRNA translation pre-initiation complex (state-1A); 16S ribosomal RNA 5lmn Y 20 3.55 27662086 300852 aggcaaggagguaaaaaugu .................... .................... Structure of bacterial 30S-IF1-IF3-mRNA translation pre-initiation complex (state-1A); mRNA 5lmo A 1514 4.3 RF00177,RF01959,RF01960 URS000080E226_300852 27662086 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggauaccuccuuu ....<<<<...[((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<<<<<<<<.......>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<<....>>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<.<..<<<<<<<....<<<......>>>.......>>>>>>>...>.......<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<...<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<<....>>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>......>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............. ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.....)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].]((((..(((((((.((..(((.(..((((((((((......((........))..........(((((((..(...((((((.(..(((((((....)))))))...((((....))))...)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..((...(((.....)))).)...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..).))).....(((((((......]...)))))))......))...))))))).)).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}............ Structure of bacterial 30S-IF1-IF3-mRNA translation pre-initiation complex (state-1B); 16S rRNA 5lmo Y 13 4.3 27662086 300852 aggcaaggaggua ............. ............. Structure of bacterial 30S-IF1-IF3-mRNA translation pre-initiation complex (state-1B); mRNA 5lmp A 1514 5.35 RF00177,RF01959,RF01960 URS000080E226_300852 27662086 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggauaccuccuuu ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<<<<<<<<.......>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<...<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<<....>>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>......>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............. ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.....)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((.(..(((((((....)))))))...((((....))))...)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..((...(((.....)))).)...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}............ Structure of bacterial 30S-IF1-IF3-mRNA translation pre-initiation complex (state-1C); 16S rRNA 5lmp Y 20 5.35 27662086 300852 aggcaaggagguaaaaaugu .................... .................... Structure of bacterial 30S-IF1-IF3-mRNA translation pre-initiation complex (state-1C); mRNA 5lmq A 1514 4.2 RF00177,RF01959,RF01960 URS000080E226_300852 27662086 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggauaccuccuuu ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<<<<<<<<.......>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<<....>>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<<....>>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............. ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.....)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...((((((.....((((((....))))))....((((....))))....))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..((...(((.....)))).)...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}............ Structure of bacterial 30S-IF1-IF3-mRNA-tRNA translation pre-initiation complex, open form (state-2A); 16S rRNA 5lmq Y 21 4.2 27662086 300852 aggcaaggagguaaaaauguu ..................... ..................... Structure of bacterial 30S-IF1-IF3-mRNA-tRNA translation pre-initiation complex, open form (state-2A); mRNA 5lmq Z 77 4.2 RF00005 URS000041AF00_562 27662086 0030533 0006412 562 cgcggggnggagcagccugguagcucgucgggnucauaacccgaagnucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(.((...].....)).)))))))..... Structure of bacterial 30S-IF1-IF3-mRNA-tRNA translation pre-initiation complex, open form (state-2A); tRNA 5lmr A 1515 4.45 RF00177,RF01959,RF01960 URS000080E226_300852 27662086 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucaccuccuuu ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<<<<<<<<.......>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<<....>>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<.<..<<<<<<<.<..<<<......>>>.....>.>>>>>>>...>.......<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<<....>>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.............. ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.....)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((......((((((.(..(((((((....)))))))...((((....))))...)))))))..((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..((...(((.....)))).)...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}............. Structure of bacterial 30S-IF1-IF3-mRNA-tRNA translation pre-initiation complex(state-2B); 16S rRNA 5lmr Y 17 4.45 27662086 300852 aggcaaggagguaaugu ................. ................. Structure of bacterial 30S-IF1-IF3-mRNA-tRNA translation pre-initiation complex(state-2B); mRNA 5lmr Z 77 4.45 RF00005 URS000041AF00_300852 27662086 0030533 0006412 300852 cgcggggnggagcagccugguagcucgucgggnucauaacccgaagnucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(((((.......)))))))))))..... Structure of bacterial 30S-IF1-IF3-mRNA-tRNA translation pre-initiation complex(state-2B); tRNAi 5lms A 1514 5.1 RF00177,RF01959,RF01960 URS000080E226_300852 27662086 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggauaccuccuuu ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<<<<<<<<.......>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<<....>>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<<....>>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<...<<<.....>>>.>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<..<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>..>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............. ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.....)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((.(...((((((....))))))....((.(....).))...)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..((...(((.....)))).)...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}............ Structure of bacterial 30S-IF1-IF3-mRNA-tRNA translation pre-initiation complex(state-2C); 16S rRNA 5lms Y 20 5.1 27662086 274 aggcaaggagguaaaaaugu .................... .................... Structure of bacterial 30S-IF1-IF3-mRNA-tRNA translation pre-initiation complex(state-2C); mRNA 5lms Z 77 5.1 RF00005 URS000041AF00_562 27662086 0030533 0006412 562 cgcggggnggagcagccugguagcucgucgggnucauaacccgaagnucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(.(((..]....))).)))))))..... Structure of bacterial 30S-IF1-IF3-mRNA-tRNA translation pre-initiation complex(state-2C); tRNAi 5lmt A 1515 4.15 RF00177,RF01959,RF01960 URS000080E226_300852 27662086 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucaccuccuuu ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<<<<<<<<.......>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<..[.>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>.......]..<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<.<..<<<<<<<.<..<<<......>>>.....>.>>>>>>>...>.......<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<...<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<<....>>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>......>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.............. ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.....)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((.(...((((((....))))))....((.(....).))...)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..((...(((.....)))).)...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}............. Structure of bacterial 30S-IF1-IF3-mRNA-tRNA translation pre-initiation complex(state-3); 16S ribosomal RNA 5lmt Y 20 4.15 27662086 274 aggcaaggagguaaaaaugu .................... .................... Structure of bacterial 30S-IF1-IF3-mRNA-tRNA translation pre-initiation complex(state-3); mRNA 5lmt Z 77 4.15 RF00005 URS000041AF00_300852 27662086 0030533 0006412 300852 cgcggggnggagcagccugguagcucgucgggnucauaacccgaagnucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Structure of bacterial 30S-IF1-IF3-mRNA-tRNA translation pre-initiation complex(state-3); tRNAi 5lmu A 1515 4.0 RF00177,RF01959,RF01960 URS000080E226_300852 27662086 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucaccuccuuu ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<<<<<<<<.......>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<<....>>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<.<..<<<<<<<.<..<<<......>>>.....>.>>>>>>>...>.......<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<<....>>>>..>>>>>>>>.<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<..<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>..>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.............. ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.....)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((.(..(((((((....)))))))...((((....))))...)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..((...(((.....)))).)...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}............. Structure of bacterial 30S-IF3-mRNA-tRNA translation pre-initiation complex, closed form (state-4); 16S ribosomal RNA 5lmu Y 20 4.0 27662086 300852 aggcaaggagguaaaaaugu .................... .................... Structure of bacterial 30S-IF3-mRNA-tRNA translation pre-initiation complex, closed form (state-4); mRNA 5lmu Z 77 4.0 RF00005 URS000041AF00_562 27662086 0030533 0006412 562 cgcggggnggagcagccugguagcucgucgggnucauaacccgaagnucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Structure of bacterial 30S-IF3-mRNA-tRNA translation pre-initiation complex, closed form (state-4); tRNAi 5lmv A 1515 4.9 RF00177,RF01959,RF01960 URS000080E226_300852 27662086 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucaccuccuuu ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<<<<<<<<.......>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<<....>>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<<....>>>>..>>>>>>>>.<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.............. ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.....)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((.....((((((....))))))....((((....))))....))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..((...(((.....)))).)...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}............. Structure of bacterial 30S-IF1-IF2-IF3-mRNA-tRNA translation pre-initiation complex(state-III); 16S ribosomal RNA 5lmv Y 20 4.9 27662086 300852 aggcaaggagguaaaaaugu .................... .................... Structure of bacterial 30S-IF1-IF2-IF3-mRNA-tRNA translation pre-initiation complex(state-III); mRNA 5lmv Z 77 4.9 RF00005 URS000041AF00_562 27662086 0030533 0006412 562 cgcggggnggagcagccugguagcucgucgggnucauaacccgaagnucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Structure of bacterial 30S-IF1-IF2-IF3-mRNA-tRNA translation pre-initiation complex(state-III); tRNAi 5lqo A 10 1.87 URS0000BC467A_9606 28623187 9606 gncggacggc .......... .......... RNA duplex has central consecutive GA pairs flanked by G-C basepairs; RNA (5'-R(*GP*(CBV)P*CP*GP*GP*AP*CP*GP*GP*C)-3') 5lqo B 10 1.87 URS0000BC467A_9606 28623187 9606 gncggacggc .......... .......... RNA duplex has central consecutive GA pairs flanked by G-C basepairs; RNA (5'-R(*GP*(CBV)P*CP*GP*GP*AP*CP*GP*GP*C)-3') 5lqt A 10 1.5 URS0000BC467A_9606 28623187 9606 gncggncggc .......... .......... RNA duplex has central consecutive GA pairs flanked by G-C basepairs; RNA (5'-R(*GP*(CBV)P*CP*GP*GP*(6MZ)P*CP*GP*GP*C)-3') 5lqt B 10 1.5 URS0000BC467A_9606 28623187 9606 gncggncggc .......... .......... RNA duplex has central consecutive GA pairs flanked by G-C basepairs; RNA (5'-R(*GP*(CBV)P*CP*GP*GP*(6MZ)P*CP*GP*GP*C)-3') 5lqw 2 81 5.8 RF00004 URS000023C730_4932 27562955 0045131 0000348 0005686 4932 gaaucucuuugccuuuuggcuuagaucaaguguaguaucuguucuuuucaguguaacaacugaaaugaccucaaugaggcu ...............................................<<<<<......>>>>>.....<<<<...>>>>.. ...............................................(((((......))))).....(((.....))).. yeast activated spliceosome; U2 snRNA 5lqw 5 141 5.8 RF00020 URS0000514318_4932 27562955 0000244,0000353 0005682,0046540 4932 cagcuuuacagaucaauggcggagggaggucaacaucaagaacugugggcgccuauagaacuuauaacgaacaugguucuugccuuuuaccagaaccauccggguguugucuccauagaaacagguaaagcuguauuuuuu <<<<<<<<<.......<.......<<<<<.<<<<<<.<<<..<<<<<<<..>>>>>>>..>>>.........<<<<<<<<...........>>>>>>>>....>>>>>>>>>>>......>...>>>>>>>>>........ (((((((((.......(.......(((((.(((((.((((..((((.((())).))))..))).....(...((((((((...........)))))))).).).))))))))))......)...)))))))))........ yeast activated spliceosome; U5 snRNA 5lqw 6 102 5.8 RF00026 URS00006184A9_4932 27562955 0030621 0000244,0000353 0005688,0046540 4932 guucgcgaaguaacccuucguggacauuuggucaauuugaaacaauacagagaugaucagcaguuccccugcauaaggaugaaccguuuuacaaagagauuu ...<<<<<<<.....>>>>>>>..............................................<<.....>>......................... ...(((((((.....))))))).........................................(..(.((.....).)..).)................... yeast activated spliceosome; U6 snRNA 5lqw 9 54 5.8 27562955 4932 cugaauuaacaauggauucugguauguucuguacuaacaucgauugcuucauuc ...................................................... ...................................................... yeast activated spliceosome; actin pre-mRNA 5lr3 A 10 1.65 URS0000BC46A2_9606 28623187 9606 gncggauggc .......... .......... RNA duplex has central consecutive GA pairs flanked by G-U basepairs; RNA (5'-R(*GP*(CBV)P*CP*GP*GP*AP*UP*GP*GP*C)-3') 5lr3 B 10 1.65 URS0000BC46A2_9606 28623187 9606 gncggauggc .......... .......... RNA duplex has central consecutive GA pairs flanked by G-U basepairs; RNA (5'-R(*GP*(CBV)P*CP*GP*GP*AP*UP*GP*GP*C)-3') 5lr4 A 10 1.8 URS0000BC46A2_9606 28623187 9606 gncggnuggc .......... .......... RNA duplex has central consecutive GA pairs flanked by G-U basepairs with a methyl group on the adenine N6; RNA (5'-R(*GP*(CBV)P*CP*GP*GP*(6MZ)P*UP*GP*GP*C)-3') 5lr4 B 10 1.8 URS0000BC46A2_9606 28623187 9606 gncggnuggc .......... .......... RNA duplex has central consecutive GA pairs flanked by G-U basepairs with a methyl group on the adenine N6; RNA (5'-R(*GP*(CBV)P*CP*GP*GP*(6MZ)P*UP*GP*GP*C)-3') 5lr4 C 10 1.8 URS0000BC46A2_9606 28623187 9606 gncggnuggc .......... .......... RNA duplex has central consecutive GA pairs flanked by G-U basepairs with a methyl group on the adenine N6; RNA (5'-R(*GP*(CBV)P*CP*GP*GP*(6MZ)P*UP*GP*GP*C)-3') 5lr4 D 10 1.8 URS0000BC46A2_9606 28623187 9606 gncggnuggc .......... .......... RNA duplex has central consecutive GA pairs flanked by G-U basepairs with a methyl group on the adenine N6; RNA (5'-R(*GP*(CBV)P*CP*GP*GP*(6MZ)P*UP*GP*GP*C)-3') 5lr5 A 10 2.4 URS000086850F_9606 28623187 9606 ggncuagunc .......... .......... N6-methyladenine is accommodated in a conventional A-U basepair; RNA (5'-R(*GP*GP*(6MZ)P*CP*UP*AP*GP*UP*(CBV)P*C)-3') 5lr5 B 10 2.4 URS000086850F_9606 28623187 9606 ggncuagunc .......... .......... N6-methyladenine is accommodated in a conventional A-U basepair; RNA (5'-R(*GP*GP*(6MZ)P*CP*UP*AP*GP*UP*(CBV)P*C)-3') 5lr5 C 10 2.4 URS000086850F_9606 28623187 9606 ggncuagunc .......... .......... N6-methyladenine is accommodated in a conventional A-U basepair; RNA (5'-R(*GP*GP*(6MZ)P*CP*UP*AP*GP*UP*(CBV)P*C)-3') 5lr5 D 10 2.4 URS000086850F_9606 28623187 9606 ggncuagunc .......... .......... N6-methyladenine is accommodated in a conventional A-U basepair; RNA (5'-R(*GP*GP*(6MZ)P*CP*UP*AP*GP*UP*(CBV)P*C)-3') 5lyb 2 1781 3.25 RF01960,RF01959,RF00177 URS00005F2C2D_4932 27827794 0003735 0005840 4932 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucau ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[..................<.....<<.<<.......>>.>>......>.........<<<<<..<......>..>>>>>[...((((((......<<<<<<<<<<<....>>>..............)))))).....]...<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<.<<.<<.<..........>.>>.>>..>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.[[....<<<<<<.<<<<<....<..>....>>>>>.>>>>>>....<<<<<<...........<.......>...........>>>>>>....<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>..........[[...((((((((....>>>>>>>>.))))))))..]].....]]....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>>....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<.<<...<.........>....>>.>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>....... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[[[[[[[(((....))).....(......).)))))).)...).(.((((..((.......)).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....((..(.(((............))).)...))......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((((.....().....))))).))))))....((((((...............................))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(......((.(((....]]]]]]]].))).)).....).....))...(((..((..(...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)..))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.((..........))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...((.((...(....................)...)).))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>...... Crystal structure of the S.cerevisiae 80S ribosome in complex with the A-site bound aminoacyl-tRNA analog ACCPmn; 18S rRNA 5lyb 1 3149 3.25 RF02540,RF02543 URS0000A7632E_4932 27827794 0003735 0005840 4932 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[...<.......<<.<<<<<<...>>>>>>.>>.......>.....<<<<<<.<<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<......<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<...<<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>>.<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>>..<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<<....>>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<.<<<<<<<<<<......>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<...<<.....<<<<....>>>>.....>>.>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<.....>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((......((((.(....).)))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...((((((.....)))))).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((.(((...((.........))...))).....(...(........).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....))).........(....(.....)......)....))....))...(((((........)))))]]((((..(((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((((.(...)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.........)))))))....((((.....((((..((((........))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(.(.((..)..).).)..)))))...)))....)))).)))))).))))).. Crystal structure of the S.cerevisiae 80S ribosome in complex with the A-site bound aminoacyl-tRNA analog ACCPmn; 25S rRNA 5lyb 3 121 3.25 RF00001 URS000055688D_4932 27827794 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of the S.cerevisiae 80S ribosome in complex with the A-site bound aminoacyl-tRNA analog ACCPmn; 5S rRNA 5lyb 4 158 3.25 RF00002 URS00001BF64E_4932 27827794 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((...(.]].)..........).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of the S.cerevisiae 80S ribosome in complex with the A-site bound aminoacyl-tRNA analog ACCPmn; 5.8S rRNA 5lyb 6 1795 3.25 RF01960,RF01959,RF00177 URS00005F2C2D_4932 27827794 0003735 0005840 4932 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...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[...............<.....<<.<<.......>>.>>......>.........<<<<<..<<....>>..>>>>>[...((((((......<<<<<<<<<<<....>>>..............)))))).....]...<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<<<<...<......>...>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.{{....<<<<<<.<<<..<<<<...............>>>>......>>>.>>>>>>....<<<<<<....<<..<<<<.......>>>>..>>....>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[[..((((((((....>>>>>>>>.)))))))).]]].....}}....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<.<....>.>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<......<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<<<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>...>.>>>>>>>.......>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<.<<<..<.........>...>>>.>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... 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Crystal structure of the S.cerevisiae 80S ribosome in complex with the A-site bound aminoacyl-tRNA analog ACCPmn; 18S rRNA 5lyb 5 3150 3.25 RF02540,RF02543 URS0000A7632E_4932 27827794 0003735 0005840 4932 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........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..)))))).))...)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((...........(((((((((((((((((((((((.......(((((((......((((((....)))))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...(.((((.....)))).).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.......(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((..((((((....((.....))..)))))....[[(((.((...((....(((....)))........(.(....(...).....).)....))....))...(((((........)))))]]((((.((((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....))))..)))))))).))).))).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((..)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...(......((((....))))......).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(..(............)..)....((((.....((((..((((........))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.............))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Crystal structure of the S.cerevisiae 80S ribosome in complex with the A-site bound aminoacyl-tRNA analog ACCPmn; 25S rRNA 5lyb 7 121 3.25 RF00001 URS000055688D_4932 27827794 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of the S.cerevisiae 80S ribosome in complex with the A-site bound aminoacyl-tRNA analog ACCPmn; 5S rRNA 5lyb 8 158 3.25 RF00002 URS00001BF64E_4932 27827794 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of the S.cerevisiae 80S ribosome in complex with the A-site bound aminoacyl-tRNA analog ACCPmn; 5.8S rRNA 5lza a 1539 3.6 RF00177,RF01959,RF01960 URS000080DDC0_562 27842381 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<..........>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.<...>.>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((.(.......)..))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((..(((((((....)))))))....(....)...))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....))))))))..)).)))))))).(...((((((......(((..((...(((....)))...))....)))......))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Structure of the 70S ribosome with SECIS-mRNA and P-site tRNA (Initial complex, IC); 16S ribosomal RNA 5lza v 77 3.6 RF00005 URS00001BBAFC_562 27842381 0030533 0006412 562 cgcggggnggagcagccuggnagcucgucgggcucauaacccgaagaucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Structure of the 70S ribosome with SECIS-mRNA and P-site tRNA (Initial complex, IC); fMet-tRNAfMet 5lza x 48 3.6 RF01988 27842381 0001514 562 aaggagguucauuaaugugacacggcccaucgguugcaggucugcacc ...............................<<.<<<<....>>>>>> ..................................((((....)))).. Structure of the 70S ribosome with SECIS-mRNA and P-site tRNA (Initial complex, IC); SECIS mRNA 5lza A 2900 3.6 RF02540,RF02541 URS000080E25C_562 27842381 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<......>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<....<<...........>>....>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<..<<....>>...>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<<<<............<<<<<<<<....>>>>>>>>...................>>>>..>.>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>.(<<...<<<<<<<...<<<<<<.......>>>>>>.....<<)..(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....(((((((..(((]]]..].)))......)))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......((((((((((.((.(((...(((((......)))))[[......(((.....]])))...)))...)).))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((((..)))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((.(((....)))..))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.((.((.(.......................).....(..(((......)))).)).))...)))..))))).))...........]]].)...))))))))))...)))))))((((((..........))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.(..(.(..........((.(...(........(((.(((....))).))).....).............).)).).)..).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Structure of the 70S ribosome with SECIS-mRNA and P-site tRNA (Initial complex, IC); 23S ribosomal RNA 5lza B 120 3.6 RF00001 URS0000049E57_562 27842381 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.....<.<<<<<<<<...>>>>>>>>...>...>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Structure of the 70S ribosome with SECIS-mRNA and P-site tRNA (Initial complex, IC); 5S ribosomal RNA 5lzb a 1539 5.3 RF00177,RF01959,RF01960 URS000080DDC0_562 27842381 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<.<<....>>.>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<..))).>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.<.....<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.....>...>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<..<.<<<<<<<........>>>>>>>>...>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<...<<....>>..>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((((..(....)..)))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((...(((((((.......))))))).)))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......(.((....)).).....))))...(.(((((...(....((((((((.......)))))))).....)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))...((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Structure of SelB-Sec-tRNASec bound to the 70S ribosome in the initial binding state (IB); 16S ribosomal RNA 5lzb v 77 5.3 RF00005 URS00001BBAFC_562 27842381 0030533 0006412 562 cgcggggnggagcagccuggnagcucgucgggcucauaacccgaagaucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Structure of SelB-Sec-tRNASec bound to the 70S ribosome in the initial binding state (IB); fMet-tRNAfMet 5lzb x 48 5.3 RF01988 27842381 0001514 562 aaggagguucauuaaugugacacggcccaucgguugcaggucugcacc ...............................<<.<<<<....>>>>>> ...............................((.(((((..))))))) Structure of SelB-Sec-tRNASec bound to the 70S ribosome in the initial binding state (IB); SECIS mRNA 5lzb y 95 5.3 RF01852 URS00002F9CDD_562 27842381 0030533 0006412 562 ggaagaucgucgucuccggngaggcggcuggacuucanauccaguuggggccgccagcggucccgggcaggnucgacuccugugaucuuccgcca <<<<<<<<..<<<<<<....>>>>>><<<<<.........>>>>>.<<<<<<<....>>>>>>>..<<<<<.......>>>>>>>>>>>>>.... ((((((((..((((((..[.))))))((((((.......)))))).(((((((....)))))))..(((((..]....))))))))))))).... Structure of SelB-Sec-tRNASec bound to the 70S ribosome in the initial binding state (IB); Sec-tRNASec 5lzb A 2903 5.3 RF02540,RF02541 URS000080E25C_562 27842381 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<.........>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<..<.....................>.........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<..<<....>>...>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<..<<.............<<....<<.......<<<<<<<<....>>>>>>>>....>>..............>>...>.>..>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[......(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..))))...(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(.(((((.....)))))..)...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((...............................(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((..........))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).[..(((((......].)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.(..(.(...........(.....(.........((.(((....))).))......)...............)..).)..).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Structure of SelB-Sec-tRNASec bound to the 70S ribosome in the initial binding state (IB); 23S ribosomal RNA 5lzb B 120 5.3 RF00001 URS0000049E57_562 27842381 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Structure of SelB-Sec-tRNASec bound to the 70S ribosome in the initial binding state (IB); 5S ribosomal RNA 5lzc a 1539 4.8 RF00177,RF01959,RF01960 URS000080DDC0_562 27842381 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<...<<<<<<<..<....>..>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<......>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<...<<<<<<.........>>>>>>.>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>..<<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>>.<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<.<.....<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.....>...>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((((..(....)..)))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((...(((((((.......))))))).)))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(..(.((((((((.......)))))))).)...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))....(....)...))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Structure of SelB-Sec-tRNASec bound to the 70S ribosome in the codon reading state (CR); 16S ribosomal RNA 5lzc v 77 4.8 RF00005 URS00001BBAFC_562 27842381 0030533 0006412 562 cgcggggnggagcagccuggnagcucgucgggcucauaacccgaagaucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Structure of SelB-Sec-tRNASec bound to the 70S ribosome in the codon reading state (CR); fMet-tRNAfMet 5lzc x 48 4.8 RF01988 27842381 0001514 562 aaggagguucauuaaugugacacggcccaucgguugcaggucugcacc ...............................<<.<<<<....>>>>>> ...............................((.(((((..))))))) Structure of SelB-Sec-tRNASec bound to the 70S ribosome in the codon reading state (CR); SECIS mRNA 5lzc y 95 4.8 RF01852 URS00002F9CDD_562 27842381 0030533 0006412 562 ggaagaucgucgucuccggngaggcggcuggacuucanauccaguuggggccgccagcggucccgggcaggnucgacuccugugaucuuccgcca <<<<<<<<..<<<<<<....>>>>>><<<<<.........>>>>>.<<<<<<<....>>>>>>>..<<<<<.......>>>>>>>>>>>>>.... ((((((((..((((((..[.))))))((((((.......)))))).(((((((....)))))))..(((((..]....))))))))))))).... Structure of SelB-Sec-tRNASec bound to the 70S ribosome in the codon reading state (CR); Sec-tRNASec 5lzc A 2903 4.8 RF02540,RF02541 URS000080E25C_562 27842381 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<.........>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<..<.....................>.........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><<<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>.>>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>.>........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<..<<....>>...>>>>>..>....>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<...<............<<<....<<<......<<<<<<<<....>>>>>>>>...>>>..............>>>..>....>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[......(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..))))...(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(.(((((.....)))))..)...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((...............................(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((.(......).))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).[..(((((......].)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.(..(.(..........((....(((........((((((....)))))).....)))..............)).).)..).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Structure of SelB-Sec-tRNASec bound to the 70S ribosome in the codon reading state (CR); 23S ribosomal RNA 5lzc B 120 4.8 RF00001 URS0000049E57_562 27842381 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.....<.<<<<<<<<...>>>>>>>>...>...>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Structure of SelB-Sec-tRNASec bound to the 70S ribosome in the codon reading state (CR); 5S ribosomal RNA 5lzd a 1539 3.4 RF00177,RF01959,RF01960 URS000080DDC0_562 27842381 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<..<....>..>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<...<<<<<<.........>>>>>>.>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.<...>.>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((((..(....)..)))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((...(((((((.......))))))).)))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(..(.((((((((.......)))))))).)...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))...((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Structure of SelB-Sec-tRNASec bound to the 70S ribosome in the GTPase activated state (GA); 16S ribosomal RNA 5lzd v 77 3.4 RF00005 URS00001BBAFC_562 27842381 0030533 0006412 562 cgcggggnggagcagccuggnagcucgucgggcucauaacccgaagaucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Structure of SelB-Sec-tRNASec bound to the 70S ribosome in the GTPase activated state (GA); fMet-tRNAfMet 5lzd x 48 3.4 RF01988 27842381 0001514 562 aaggagguucauuaaugugacacggcccaucgguugcaggucugcacc ...............................<<.<<<<....>>>>>> ...............................((.(((((..))))))) Structure of SelB-Sec-tRNASec bound to the 70S ribosome in the GTPase activated state (GA); SECIS mRNA 5lzd y 95 3.4 RF01852 URS00002F9CDD_562 27842381 0030533 0006412 562 ggaagaucgucgucuccggngaggcggcuggacuucanauccaguuggggccgccagcggucccgggcaggnucgacuccugugaucuuccgcca <<<<<<<<..<<<<<<....>>>>>><<<<<<.......>>>>>><<<<<<<<....>>>>>>>>.<<<<<.......>>>>>>>>>>>>>.... ((((((((..((((((..[.))))))((((((.......))))))((((((((....)))))))).(((((..]....))))))))))))).... Structure of SelB-Sec-tRNASec bound to the 70S ribosome in the GTPase activated state (GA); Sec-tRNASec 5lzd A 2903 3.4 RF02540,RF02541 URS000080E25C_562 27842381 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<....<.<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>..>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<.......>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<..<...<.............>...>.........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<<.<<....>>..>>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<...<.............<<....<<<......<<<<<<<<....>>>>>>>>...>>>..............>>...>....>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>.(<<...<<<<<<<...<<<<<<.......>>>>>>.....<<)..(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[......(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((((..)))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(.(((((.....)))))..)...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((...............................(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((............)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.(..(.(..........((.....(.........((.(((....))).))......)...............)).).)..).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....((.((((.((..]]]]..)))))).)).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Structure of SelB-Sec-tRNASec bound to the 70S ribosome in the GTPase activated state (GA); 23S ribosomal RNA 5lzd B 120 3.4 RF00001 URS0000049E57_562 27842381 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Structure of SelB-Sec-tRNASec bound to the 70S ribosome in the GTPase activated state (GA); 5S ribosomal RNA 5lze a 1539 3.5 RF00177,RF01959,RF01960 URS000080DDC0_562 27842381 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<............>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..........>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.<...>.>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((..(......)..))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..(......))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(..(.((((((((.......)))))))).)...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((..(((((((....)))))))....(....)...))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....))))))))..)).)))))))).(...((((((......(((..((...(((....)))...))....)))......))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Structure of the 70S ribosome with Sec-tRNASec in the classical pre-translocation state (C); 16S ribosomal RNA 5lze v 77 3.5 RF00005 URS00001BBAFC_562 27842381 0030533 0006412 562 cgcggggnggagcagccuggnagcucgucgggcucauaacccgaagaucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Structure of the 70S ribosome with Sec-tRNASec in the classical pre-translocation state (C); tRNAfMet 5lze x 48 3.5 RF01988 27842381 0001514 562 aaggagguucauuaaugugacacggcccaucgguugcaggucugcacc ..................................<<<<....>>>>.. ..................................(((((..))))).. Structure of the 70S ribosome with Sec-tRNASec in the classical pre-translocation state (C); SECIS mRNA 5lze y 95 3.5 RF01852 URS00002F9CDD_562 27842381 0030533 0006412 562 ggaagaucgucgucuccggngaggcggcuggacuucanauccaguuggggccgccagcggucccgggcaggnucgacuccugugaucuuccgcca <<<<<<<<..<<<<<<....>>>>>><<<<<<.......>>>>>><<<<<<<......>>>>>>>.<<<<<.......>>>>>>>>>>>>>.... ((((((((..((((((..[.))))))((((((.......))))))(((((((......))))))).(((((..]....))))))))))))).... Structure of the 70S ribosome with Sec-tRNASec in the classical pre-translocation state (C); fMetSec-tRNASec 5lze A 2900 3.5 RF02540,RF02541 URS000080E25C_562 27842381 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<....<.<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>..>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<<..>>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<....>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<....<<<.........>>>....>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<..<<....>>..>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<<<<<............<<<<<<<....>>>>>>>...................>>>>>..>.>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......((((((((((.((.(((...(((((......)))))[[......(((.....]])))...)))...)).))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((((..)))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((((.(....).)).))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.((.((.(.....((.........).)....).....(..(((......)))).)).))...)))..))))).))...........]]].)...))))))))))...)))))))((((((..........))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..(((.(....).)))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.(..(.(..........((((...(........((..(((....)))..)).....).............)))).).)..).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....((.((((.((..]]]]..)))))).)).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Structure of the 70S ribosome with Sec-tRNASec in the classical pre-translocation state (C); 23S ribosomal RNA 5lze B 120 3.5 RF00001 URS0000049E57_562 27842381 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Structure of the 70S ribosome with Sec-tRNASec in the classical pre-translocation state (C); 5S ribosomal RNA 5lzf a 1539 4.6 RF00177,RF01959,RF01960 URS000080DDC0_562 27842381 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<...<....>...>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<..<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>.........>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((..((....))..))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....(((((......)))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((.(.........)))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(..(.((((((((.......)))))))).)...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((..(((((((....)))))))....(....)...))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....))))))))..)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Structure of the 70S ribosome with fMetSec-tRNASec in the hybrid pre-translocation state (H); 16S ribosomal RNA 5lzf v 77 4.6 RF00005 URS00001BBAFC_562 27842381 0030533 0006412 562 cgcggggnggagcagccuggnagcucgucgggcucauaacccgaagaucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Structure of the 70S ribosome with fMetSec-tRNASec in the hybrid pre-translocation state (H); tRNAfMet 5lzf x 48 4.6 RF01988 27842381 0001514 562 aaggagguucauuaaugugacacggcccaucgguugcaggucugcacc ..................................<<<<....>>>>.. ...................................((((..))))... Structure of the 70S ribosome with fMetSec-tRNASec in the hybrid pre-translocation state (H); SECIS mRNA 5lzf y 95 4.6 RF01852 URS00002F9CDD_562 27842381 0030533 0006412 562 ggaagaucgucgucuccggngaggcggcuggacuucanauccaguuggggccgccagcggucccgggcaggnucgacuccugugaucuuccgcca <<<<<<<<..<<<<<<....>>>>>><<<<<<.......>>>>>><<<<<<<......>>>>>>>.<<<<<.......>>>>>>>>>>>>>.... ((((((((..((((((..[.))))))((((((.......))))))((((((((....))))))))..((((..]....)))).)))))))).... Structure of the 70S ribosome with fMetSec-tRNASec in the hybrid pre-translocation state (H); fMetSec-tRNASec 5lzf A 2900 4.6 RF02540,RF02541 URS000080E25C_562 27842381 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<..<<......>>...>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<......<<...........>>.............<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<<.<<....>>..>>>>>>..>....>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<.<.............<<...<<<......<<<<<<<<....>>>>>>>>...>>>.............>>....>.>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<.....<....>....>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.)))....(((((((...(((]]]..].))).......)))))).).)))....(((....)))((((((......)))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......((((((((((.((.(((...(((((......)))))[[......(((.....]])))...)))...)).))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((((..)))))))..))))...(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..(((.((((((.....(((...(((.((((...(..((......))...)...)))).)))..)).).....))))))..))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(.......................).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((..........))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).[..(((((......].)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.(..(.(.........(.((....((........(..(((....)))..).....))..............))).).)..).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....((.((((.((..]]]]..)))))).)).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Structure of the 70S ribosome with fMetSec-tRNASec in the hybrid pre-translocation state (H); 23S ribosomal RNA 5lzf B 120 4.6 RF00001 URS0000049E57_562 27842381 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<...<.<.<<<<<<<<...>>>>>>>>...>.>.>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Structure of the 70S ribosome with fMetSec-tRNASec in the hybrid pre-translocation state (H); 5S ribosomal RNA 5lzs 2 76 3.31 RF00005 URS0000868530_9986 27863242 0030533 9986 gucuccguaguguagcgguuaucacguucgccuaacacgcgaaagguccucgguucgaaaccgggcggaaacacca <<.<<<<..<<<..........>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>.>>.... ((.((((..(((.....[....))).(((((.......))))).....(((((..]....))))))))).)).... Structure of the mammalian ribosomal elongation complex with aminoacyl-tRNA, eEF1A, and didemnin B; tRNA 5lzs 3 75 3.31 RF00005 URS000086855F_9986 27863242 0030533 0006412 9986 gcccggauagcucagcuguagagcaucagacuuuuaaucugaggguccaggguucaagucccuguucgggcgcca <<<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... ((((.((..((((....[..)))).(((((.......))))).....(((((..]....))))))).)))).... Structure of the mammalian ribosomal elongation complex with aminoacyl-tRNA, eEF1A, and didemnin B; E-site tRNA 5lzs 5 3543 3.31 RF02540,RF02543 URS0000A7632C_9986 27863242 0003735 0005840 9986 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggaaauguggcguacggaagacccacuccccggcgccggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcgcgguccggccgugccggcggggcggaucucccgcucccgucggcgggggaccgccccccggccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggccccggcggggaagguggcccgggggccccggguguuacagccccgccccggcagcagcagcucgccgaaucccggggccgagggagcgagacccgugcgccgcgcucuccccccucgggggggccgggccaccccucccacggcgcgaccgcuggggcggacuguccagugcgccccgggcgggucgcgccgucgggcccggggggccacgcgucccccgcgagcgcacggggucggcggcgaugucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcuacgaaagccgccguggcgcaaugaaggugaaggccggcggcgcgccgccggccgaggugggaucccgaggccuuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcgaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccaaaguuucccucaggauagcuggcgcucuccgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcugguguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggaugguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgcuggcagucggcagagcgagaaagagaguggcgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucagccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcuggcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacguuuuuucacugacccggugaggcgggggggcgagccgggcucucgcuucuggcgccaagcgcccggccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauagcgccggagccucgguuggccucggauagccggucccccgccgggguccggugcggagagcccuucgucccgggaaacggggcggccggaaagggggccgcccucucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcugcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<...<<<<...<<<<<<<<<<<...>>>>>>>.>>>>.....>>>>...<<<<<<<<<....<<<<<<<<..<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>...>>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<<....<<<<<<<.<<<<<.<<<<<<<.<<<<<<<<<......>>>>>>>>>>>>>>>>>>>>>>>>>...>>>.>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<<<<<<<<<<<<<<<<<...<<..<<<..<<<<<<<......<<<<<<<<.>>>>>>>>.......>>>>>>>..>>>.........>>>>>>..>>>>>>>>>>>.....<<.......>>.........<...<<<<<<..>>>>>>.....<<...<<.<<<<<<<<<<<<<<<<<<<<<<<.<<<<..>>>>.>>>>>>.>>>.>>>>>>>>>>>.>>>...>>.>>..................>........>>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<.....>>>>.....>>>...<<....>>...<<<<<<<<<<..>>>>>>>>>>..<<<<<...<<<..<<<...(((.[[.>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<...<<<.<<<<<<<<<...<<<....<<<..<.<<<..<<<<.<.........>.>>>>>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<......<..........<<<.<<<<<<<<<<.......<<<<<.<<.....................>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>....>>>>>..>>>...>>>>>>><<<<<<.<<<....................]].)))............>>>>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<<<<<...>>>>>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<...<<<<<<<....>>>>>>>...<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<...............>>>>><<.<<<<<<<<<<<.>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<<....>>>>>>>>...<<<<<.....<<<<..<<.<<<<<>>.>>>>>..............<<<<<<<<<..>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>><<<<....>>>>>>)))].....<<<<<<<..<<<..)))))).>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.<.....>.>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<]]].>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.<<<<<<...<<<<....<<<........<<<<<..<<<<<.>>>>>.>>>>>.......>>>...<<<..<<<<....<<<<<<<<<........>>>>>>.>>>...>>>>..>>>..............>>>>....>>>>>>.<<<<<.<.............>....<<.<<<<<<<.<<.....<<<<....<<<<<.>>>>>...>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..(((((((((((.....)))))).))))....))))....(((((((((....((((((((.(((((((((..({((((......)))))....[[(...).(((....}]])))...).)))))))..)))))))))...)))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....((((((((((.(..(((((((.(((((.(((((((.((.(((((...()...))))).))))))))))))))))))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((..(((((((.......(((((((.)))))))........)))))))..))).........))))))..))))))))))).....((.....{.)).........(.(.((((((()))))))...(.((...((.(((((((((((((((((((((((.((((..)))).)))))).))).))))))))))).)))...)).)).)............[.).)........))).)))))...)))))...)))))))).<((((........))))((((((..(.(((((((((((((..(((..(((((.....))))..)..)))...((....))...((((((((((()))))))))))..(((((...(((..(((]..[[..[.[)))..)))....))))).(((((((((.((((......))))))))))).))....)))))))))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))....))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((.(((((((...(((.((((((((....(((....(((..(.(((..(((((..(.....)..)))))))).)..)))..)).)....))))))...(((((((((.(......))))))))))....))))))))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.......(((((..((....(.........)....))......(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((........}.........]..]..]]............)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...((..(.(((....))).....)....((.(((((((((...)))))))))))......))....))...(((((........)))))]]((((....(((((...(((((((....)))))))..((((....)))...(...((((((...(((((((((((((((((((((((...{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((.)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(..(((.....(((.....).)).....))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.(((((((((.(((((((......)))))))...(((((.....((((..(..(..(())...).)..............(((((.(((()))).)))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a.))..))).))))).....(((((..(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}..)))))..)).))...))))...)))).((((...((((.............))))...))))..)))...).).)))).(((((((...(((....(((.........((((...((((.))))..))))........)))...(((..(((.....(((.(((((........)))))..)))....)))..)))..............)))...).)))))).(.(((.(..(.......)..)....((.(((((((.((.....((((.(..(((((.)))))..)))))....))....)))).))).))..))))... Structure of the mammalian ribosomal elongation complex with aminoacyl-tRNA, eEF1A, and didemnin B; 28S ribosomal RNA 5lzs 7 119 3.31 RF00001 URS000002B0D5_9986 27863242 0003735 0005840 9986 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))). Structure of the mammalian ribosomal elongation complex with aminoacyl-tRNA, eEF1A, and didemnin B; 5S ribosomal RNA 5lzs 8 151 3.31 RF00002 URS00004B2C76_9986 27863242 0003735 0005840 9986 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcagguugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<<<<....>>>>.....<.<<<......>>........>>>..>...>>>....<<<..>>><<<<<<<<.......>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]]........)))..)...)))....((....))((((((((.......)))))))).................... Structure of the mammalian ribosomal elongation complex with aminoacyl-tRNA, eEF1A, and didemnin B; 5.8S ribosomal RNA 5lzs 9 1697 3.31 RF01960,RF01959,RF00177 URS00005A14E2_9986 27863242 0003735 0005840 9986 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucgacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgcccggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcggccguccccugcucggcgccggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgaccccggucggcguaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggugcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<....<<....<<<<.........<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<<<....>>>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<<.>>>>>>>>..>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....<<<<<<<<<.<<<....>>>..>>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<....<<<.<<<..>>>.>>><<<<<<<.<<..>>>>>>.>>>.<<<<<<.<.......<<...<.......>.<<<<.>>>>...>>......>.>>>..>>>........<.<<.<<<<<<<...............>>>>>>>.>>.>....>>....<<<<<<..<...<<<<..<<<.<<<<<<<<...<<<......>>>......>>>>>>>>.>>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<<....>>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<......<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<..>>>>.>>>>>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.......>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<<<<<<<<<<<..>>>>>>>>>.>.>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..((....(((.....((...((.....((.(((.....))).))......))......)).((((...((((((....))))))...))))((..(((((...(......)..)))))......)).(.((((..((...)).)))))...)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).).....(((((((((.((......))..)))))).)))....(.((..(...........)..))......)..((((([[......((((.....((..]])).......)))).)))))..)))))).)))..[......(.([[...(.(.((...(((..(....(((.(((())).)))).((((((.((())))))).))..((((((.(.......((..((.......)).(((.)))....))......).)))..)))........(.((.(((((((...............))))))).)).)....)....((((.((..(...((((..(((.((((((((...((........))......)))))))).))).......((....))...))))..)..))..)))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.(((((....))))))))))).)..)))...((..]]))...))...].))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((..((........))..))....).)))))...((.(((...(.((((((.(..(((.(((((....)))..(.((......)))...)).)))....(((...(...(((...((((((((((((..)))).))))))))..).))..).....(((((.....)))))........))).)..))).))).....).))))).....).)))))...)).)))).))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..((((.((...(((((((((((((((..))))))))).).)))))...)).))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}........ Structure of the mammalian ribosomal elongation complex with aminoacyl-tRNA, eEF1A, and didemnin B; 18S ribosomal RNA 5lzs hh 10 3.31 27863242 9986 auguucguua .......... .......... Structure of the mammalian ribosomal elongation complex with aminoacyl-tRNA, eEF1A, and didemnin B; mRNA 5lzs ii 76 3.31 RF00005 URS0000868530_9986 27863242 0030533 9986 gucuccguaguguagcgguuaucacguucgccuaacacgcgaaagguccucgguucgaaaccgggcggaaacacca <<.<<<<..<<<<.......>>.>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>.>>.... ((.((((..(..(.......)...).(((((.......))))).....(((((.......))))))))).)).... Structure of the mammalian ribosomal elongation complex with aminoacyl-tRNA, eEF1A, and didemnin B; tRNA 5lzt 2 76 3.65 RF00005 URS0000868530_9986 27863242 0030533 9986 gucuccguaguguagcgguuaucacguucgccuaacacgcgaaagguccucgguucgaaaccgggcggaaacacca <<.<<<<..<<<..........>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>.>>.... ((.((((..(((.....[....))).(((((.......))))).....(((((..]....))))))))).)).... Structure of the mammalian ribosomal termination complex with eRF1 and eRF3.; P-site tRNA 5lzt 3 75 3.65 RF00005 URS000086855F_9986 27863242 0030533 0006412 9986 gcccggauagcucagcuguagagcaucagacuuuuaaucugaggguccaggguucaagucccuguucgggcgcca <<<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... ((((.((..((((....[..)))).(((((.......))))).....(((((..]....))))))).)))).... Structure of the mammalian ribosomal termination complex with eRF1 and eRF3.; E-site tRNA 5lzt 5 3543 3.65 RF02540,RF02543 URS0000A7632C_9986 27863242 0003735 0005840 9986 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggaaauguggcguacggaagacccacuccccggcgccggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcgcgguccggccgugccggcggggcggaucucccgcucccgucggcgggggaccgccccccggccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggccccggcggggaagguggcccgggggccccggguguuacagccccgccccggcagcagcagcucgccgaaucccggggccgagggagcgagacccgugcgccgcgcucuccccccucgggggggccgggccaccccucccacggcgcgaccgcuggggcggacuguccagugcgccccgggcgggucgcgccgucgggcccggggggccacgcgucccccgcgagcgcacggggucggcggcgaugucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcuacgaaagccgccguggcgcaaugaaggugaaggccggcggcgcgccgccggccgaggugggaucccgaggccuuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcgaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccaaaguuucccucaggauagcuggcgcucuccgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcugguguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggaugguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgcuggcagucggcagagcgagaaagagaguggcgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucagccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcuggcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacguuuuuucacugacccggugaggcgggggggcgagccgggcucucgcuucuggcgccaagcgcccggccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauagcgccggagccucgguuggccucggauagccggucccccgccgggguccggugcggagagcccuucgucccgggaaacggggcggccggaaagggggccgcccucucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcugcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..[[[...<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>...<<<<<<<<<....<<<<<<<<..<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>...>>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<<....<<<<<<<.<<<<<.<<<<<<<.<<<<<<<<<......>>>>>>>>>>>>>>>>>>>>>>>>>...>>>.>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<<<<<<<<<<<<<<<<<...<<..<<<..<<<<<<<......<<<<<<<<.>>>>>>>>.......>>>>>>>..>>>.........>>>>>>..>>>>>>>>>>>.....<<.......>>.........<...<<<<<<..>>>>>>....<<<...<<.<<<<<<<<<<<<<<<<<<<<<<<.<<<<..>>>>.>>>>>>.>>>.>>>>>>>>>>>.>>>...>>.>>.>................>........>>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<<<<...<<<<<<<<<<<<<<..<<<...<<<<.....>>>>.....>>>...<<....>>...<<<<<<<<<<..>>>>>>>>>>..<<<<<...<<<..<<<...(((.[[.>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>>.<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<...<<<.<<<<<<<<<...<<<....<<<..<.<<<..<<<<.<.........>.>>>>>>>.>..>>>..>>.>...>>>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<......<..........<<<.<<<<<<<<<<.......<<<<<.<<.....................>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>....>>>>>..>>>...>>>>>>><<<<<<.<<<....................]].)))............>>>>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<<<<<...>>>>>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<...<<<<<<<....>>>>>>>...<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..{{{..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<...............>>>>><<.<<<<<<<<<<<.>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<<.<<<<<<<<....>>>>>>>>...<<<<<.....<<<<..<<.<<<<<>>.>>>>>..............<<<<<<<<<..>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>>.<<<....>>>.>>)))]......((((((..(((..>>>>>>.)))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.<.....>.>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]].....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<.}}}..>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.<<<<<<...<<<<....<<<........<<<<<..<<<<<.>>>>>.>>>>>.......>>>...<<<..<<<<....<<<<<<<<<........>>>>>>.>>>...>>>>..>>>..............>>>>....>>>>>>.<<<<<.<.............>....<<.<<<<<<<.<<.....<<<<....<<<<<.>>>>>...>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..(((((((((((.....)))))).))))....))))....(((((((((....((((((((.(((((((((..({((((......)))))....[[(...).(((....}]])))...).)))))))..)))))))))...)))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....((((((((((.(..(((((((.(((((.(((((((.((.(((((.(.()..)))))).))))))))))))))))))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((..(((((((.......(((((((.)))))))........)))))))..))).........))))))..))))))))))).....((.....{.)).........(.(.((((((()))))))...(.((...((.(((((((((((((((((((((((.((((..)))).)))))).))).))))))))))).)))...)).)).)............[.).)........))).)))))...)))))...)))))))).<((((........))))((((((....(((((((((((((..(((..(((((.....))))..)..)))...((....))...((.(((((((()))))))).))..(((((...(((..(((]..[[..[.[)))..)))....))))).(((((((((.((((......))))))))))).))....)))))))))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((...(((.((((((((....(((....(((..(.(((..(((.(..(.....)...))))))).)..)))..)).)....))))))...(((((((((.(......))))))))))....))))))))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((.(.......(((((.(((....(.........)....))).....(...((......)).).)))))...).)))))))))))..........]]].)....))))))))))...)))))))((((((.(((........}.........]..]..]]............)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...((..(.(((....))).....)....((.(((((((((...)))))))))))......))....))...(((((........)))))]]((((....(((((...(((((((....)))))))..((((....)))...(...((((((...(((((((((((((((((((((((...{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((.)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(..(((.....(((.....).)).....))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.(((((((((.((((((((....))))))))...(((((.....((((..(..(..(())...).)..............(((((.(((()))).)))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a.))..))).))))).....(((((..(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}..)))))..)).))...))))...)))).((((...((((.............))))...))))..)))...).).)))).(((((((...(((....(((.........((((...((((.))))..))))........)))...(((..(((.....(((.(((((........)))))..)))....)))..)))..............)))...).)))))).(.(((.(..(.......)..)....((.(((((((.((.....((((.(..(((((.)))))..)))))....))....)))).))).))..))))... Structure of the mammalian ribosomal termination complex with eRF1 and eRF3.; 28S ribosomal RNA 5lzt 7 120 3.65 RF00001 URS000002B0D5_9986 27863242 0003735 0005840 9986 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. Structure of the mammalian ribosomal termination complex with eRF1 and eRF3.; 5S ribosomal RNA 5lzt 8 151 3.65 RF00002 URS00004B2C76_9986 27863242 0003735 0005840 9986 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcagguugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<<<<....>>>>.....<.<<<......>>........>>>..>...>>>....<<<..>>><<<<<<<<.......>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]]........)))..)...)))....((....))((((((((.......)))))))).................... Structure of the mammalian ribosomal termination complex with eRF1 and eRF3.; 5.8S ribosomal RNA 5lzt 9 1698 3.65 RF01960,RF01959,RF00177 URS0000A7639A_9986 27863242 0003735 0005840 9986 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucguacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgcccggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcggccguccccugcucggcgccggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgaccccggucggcguaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggugcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<....<<....<<<<<.........<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<<<....>>>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<<.>>>>>>>>.>>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....<<<<<<<<<.<<<....>>>..>>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<....<<<.<<<..>>>.>>><<<<<<<.<<..>>>>>>.>>>.<<<<<<.<.......<<...<.......>.<<<<.>>>>...>>......>.>>>..>>>........<.<<.<<<<<<<...............>>>>>>>.>>.>....>>....<<<<<<..<...<<<<..<<<.<<<<<<<<...<<<......>>>......>>>>>>>>.>>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<......<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<..>>>>.>>>>>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.......>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<<<<<<<<<<<..>>>>>>>>>.>.>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..((....((((....(([...((.....((.(((.....))).))......))......)).((((...((((((....))))))...))))((..(((((...(......)..)))))......)).(]((((.(((...)))))))).).)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).).....(((((((((.((......))..)))))).)))....(.((..(...........)..))......)..((((([[......((((.....((..]])).......)))).)))))..)))))).)))..[......(.([[...(.(.((...(((..(....(((.(((())).)))).((((((.((())))))).))..((((((.(.......((..((.......)).(((.)))....))......).)))..)))........(.((.(((((((...............))))))).)).)....)....((((.(...(...((((..(((.((((((((...((........))......)))))))).))).......((....))...))))..)...)..)))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.(((((....))))))))))).)..)))...((..]]))...))...].))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((..((........))..))....).)))))...((.(((...(.((((((.(..(((.(((((....)))..(.((......)))...)).)))....(((...(...((((..((((((((((((..)))).))))))))..))))..).....(((((.....)))))........))).)..))).))).....).))))).....).)))))...)).)))).))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..((((.((...(((((((((((((((..))))))))).).)))))...)).))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}........ Structure of the mammalian ribosomal termination complex with eRF1 and eRF3.; 18S ribosomal RNA 5lzt hh 15 3.65 27863242 9986 ucaaaguuugagcuc ............... ............... Structure of the mammalian ribosomal termination complex with eRF1 and eRF3.; mRNA (UGA stop codon) 5lzu 2 76 3.75 RF00005 URS0000868530_9986 27863242 0030533 9986 gucuccguaguguagcgguuaucacguucgccuaacacgcgaaagguccucgguucgaaaccgggcggaaacacca <<.<<<<..<<<..........>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>.>>.... ((.((((..(((.....[....))).(((((.......))))).....(((((..]....))))))))).)).... Structure of the mammalian ribosomal termination complex with accommodated eRF1; P-site tRNA 5lzu 3 75 3.75 RF00005 URS000086855F_9986 27863242 0030533 0006412 9986 gcccggauagcucagcuguagagcaucagacuuuuaaucugaggguccaggguucaagucccuguucgggcgcca <<<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... ((((.((..((((....[..)))).(((((.......))))).....(((((..]....))))))).)))).... Structure of the mammalian ribosomal termination complex with accommodated eRF1; E-site tRNA 5lzu 5 3543 3.75 RF02540,RF02543 URS0000A7632C_9986 27863242 0003735 0005840 9986 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggaaauguggcguacggaagacccacuccccggcgccggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcgcgguccggccgugccggcggggcggaucucccgcucccgucggcgggggaccgccccccggccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggccccggcggggaagguggcccgggggccccggguguuacagccccgccccggcagcagcagcucgccgaaucccggggccgagggagcgagacccgugcgccgcgcucuccccccucgggggggccgggccaccccucccacggcgcgaccgcuggggcggacuguccagugcgccccgggcgggucgcgccgucgggcccggggggccacgcgucccccgcgagcgcacggggucggcggcgaugucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcuacgaaagccgccguggcgcaaugaaggugaaggccggcggcgcgccgccggccgaggugggaucccgaggccuuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcgaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccaaaguuucccucaggauagcuggcgcucuccgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcugguguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggaugguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgcuggcagucggcagagcgagaaagagaguggcgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucagccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcuggcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacguuuuuucacugacccggugaggcgggggggcgagccgggcucucgcuucuggcgccaagcgcccggccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauagcgccggagccucgguuggccucggauagccggucccccgccgggguccggugcggagagcccuucgucccgggaaacggggcggccggaaagggggccgcccucucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcugcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<...<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>...<<<<<<<<<....<<<<<<<<..<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>...>>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<......>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<<....<<<<<<<.<<<<<.<<<<<<<.<<<<<<<<<......>>>>>>>>>>>>>>>>>>>>>>>>>...>>>.>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<<<<<<<<<<<<<<<<<...<<..<<<..<<<<<<<......<<<<<<<<.>>>>>>>>.......>>>>>>>..>>>.........>>>>>>..>>>>>>>>>>>.....<<.......>>.........<...<<<<<<..>>>>>>....<<<...<<.<<<<<<<<<<<<<<<<<<<<<<<.<<<<..>>>>.>>>>>>.>>>.>>>>>>>>>>>.>>>...>>.>>.>................>........>>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<<<<...<<<<<<<<<<<<<<..<<<...<<<<.....>>>>.....>>>...<<....>>...<<<<<<<<<<..>>>>>>>>>>..<<<<<...<<<..<<<...(((.[..>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>>.<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<...<<<.<<<<<<<<<...<<<....<<<..<.<<<..<<<<.<.........>.>>>>>>>.>..>>>..>>.>...>>>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<.....................>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<.....................].)))............>>>>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<<<<<...>>>>>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<...<<<<<<<....>>>>>>>...<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>.>>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<.<<<<<<<<<<<.>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<<....>>>>>>>>...<<<<<.....<<<<..<<.<<<<<>>.>>>>>..............<<<<<<<<<..>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.((.((>>....>>>>>>>...<<<..<<<<.......>>>>..>>>.<<<....>>>.>>)))).....<<<<<<<..<<<..)))))).>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<]]].>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.<<<<<<...<<<<....<<<........<<<<<..<<<<<.>>>>>.>>>>>.......>>>...<<<..<<<<....<<<<<<<<<........>>>>>>.>>>...>>>>..>>>..............>>>>....>>>>>>.<<<<<.<.............>....<<.<<<<<<<.<<.....<<<<.<..<<<<<.>>>>>..>>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..(((((((((((.....)))))).))))....))))....(((((((((....((((((((.(((((((((..({((((......)))))....[[(...).(((....}]])))...).)))))))..)))))))))...)))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....((((((((((.(..(((((((.(((((.(((((((.((.(((((.(.()..)))))).))))))))))))))))))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((..(((((((.......(((((((.)))))))........)))))))..))).........))))))..))))))))))).....((.....{.))...........(.((((((()))))))...(.((...((.(((((((((((((((((((((((.(((....))).)))))).))).))))))))))).)))...)).)).)............[.)..........))).)))))...)))))...)))))))).<((((........))))((((((..(.(((((((((((((..(((..(((((.....))))..)..)))...((....))...((.(((((((()))))))).))..(((((...(((..(((]..[[..[.[)))..)))....))))).(((((((((.((((......))))))))))).))....)))))))))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))....))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((.(((((((...(((.((((((((....(((....(((..(.(((..(((.(..(.....)...))))))).)..)))..)).)....))))))...(((((((((.(......))))))))))....))))))))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.......(((((.(((....(.........)....))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((........}.........]..]..]]............)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...((....(((....)))..........((.(((((((((...)))))))))))......))....))...(((((........)))))]]((((....(((((...(((((((....)))))))..((((....)))...(...((((((...(((((((((((((((((((((((...{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((.)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(..(((.....(((.....).)).....))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.(((((((((.((((((((....))))))))...(((((.....((((..(..(..(())...).)..............(((((.(((()))).)))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a.))..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}..)))))..)).))...))))...)))).((((...((((.............))))...))))..)))...).)))))).(((((((...(((....(((.........((((...((((.))))..))))........)))...(((..(((.....(((.(((((........)))))..)))....)))..)))..............)))...).)))))).(.(((.(..(.......)..)....((.(((((((.((.....((((.(..(((((.)))))..)))))....))....)))).))).))..))))... Structure of the mammalian ribosomal termination complex with accommodated eRF1; 28S ribosomal RNA 5lzu 7 120 3.75 RF00001 URS000002B0D5_9986 27863242 0003735 0005840 9986 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. Structure of the mammalian ribosomal termination complex with accommodated eRF1; 5S ribosomal RNA 5lzu 8 151 3.75 RF00002 URS00004B2C76_9986 27863242 0003735 0005840 9986 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcagguugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<<<<....>>>>.....<.<<<......>>........>>>..>...>>>....<<<..>>><<<<<<<<.......>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]]........)))..)...)))....((....))((((((((.......)))))))).................... Structure of the mammalian ribosomal termination complex with accommodated eRF1; 5.8S ribosomal RNA 5lzu 9 1698 3.75 RF01960,RF01959,RF00177 URS0000A7639A_9986 27863242 0003735 0005840 9986 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucguacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgcccggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcggccguccccugcucggcgccggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgaccccggucggcguaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggugcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<....<<....<<<<..........<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<<<....>>>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<<.>>>>>>>>..>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....<<<<<<<<<.<<<....>>>..>>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<....<<<.<<<..>>>.>>><<<<<<<.<<..>>>>>>.>>>.<<<<<<.<.......<<...<.......>.<<<<.>>>>...>>......>.>>>..>>>........<.<<.<<<<<<<...............>>>>>>>.>>.>....>>....<<<<<<..<...<<<<..<<<.<<<<<<<<...<<<......>>>......>>>>>>>>.>>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<..>>>>.>>>>>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<...<.<<<<<..........>>>>>>....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<.<<<<<<<<<..>>>>>>>>>...>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..((....((((....(([...((.....((.(((.....))).))......))......)).((((...((((((....))))))...))))((..(((((...(......)..)))))......)).(]((((.(((...)))))))).).)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).).....(((((((((.((......))..)))))).)))....(.((..(...........)..))......)..((((([[......((((.....((..]])).......)))).)))))..)))))).)))..[......(.([[...(.(.((...(((..(....(((.(((())).)))).((((((.((())))))).))..((((((.(.......((..((.......)).(((.)))....))......).)))..)))........(.((.(((((((...............))))))).)).)....)....((((.(...(...((((..(((.((((((((...((........))......)))))))).))).......((....))...))))..)...)..)))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.(((((....))))))))))).)..)))...((..]]))...))...].))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((..((........))..))....).)))))...((.(((...(.((((((.(..(((.(((((....)))..(.((......)))...)).)))....(((...(...(((...((((((((((((..)))).))))))))..).))..).....(((((.....)))))........))).)..))).))).....).))))).....).)))))...)).)))).))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..((((.((...(((((((((((((((..))))))))).).)))))...)).))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}........ Structure of the mammalian ribosomal termination complex with accommodated eRF1; 18S ribosomal RNA 5lzu hh 15 3.75 27863242 9986 ucaaaguuugagcuc ............... ............... Structure of the mammalian ribosomal termination complex with accommodated eRF1; mRNA (UGA stop codon) 5lzv 2 76 3.35 RF00005 URS0000868530_9986 27863242 0030533 9986 gucuccguaguguagcgguuaucacguucgccuaacacgcgaaagguccucgguucgaaaccgggcggaaacacca <<.<<<<..<<<..........>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>.>>.... ((.((((..(((.....[....))).(((((.......))))).....(((((..]....))))))))).)).... Structure of the mammalian ribosomal termination complex with accommodated eRF1(AAQ) and ABCE1.; P-site tRNA 5lzv 3 75 3.35 RF00005 URS000086855F_9986 27863242 0030533 0006412 9986 gcccggauagcucagcuguagagcaucagacuuuuaaucugaggguccaggguucaagucccuguucgggcgcca <<<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... ((((.((..((((....[..)))).(((((.......))))).....(((((..]....))))))).)))).... Structure of the mammalian ribosomal termination complex with accommodated eRF1(AAQ) and ABCE1.; E-site tRNA 5lzv 5 3543 3.35 RF02540,RF02543 URS0000A7632C_9986 27863242 0003735 0005840 9986 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggaaauguggcguacggaagacccacuccccggcgccggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcgcgguccggccgugccggcggggcggaucucccgcucccgucggcgggggaccgccccccggccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggccccggcggggaagguggcccgggggccccggguguuacagccccgccccggcagcagcagcucgccgaaucccggggccgagggagcgagacccgugcgccgcgcucuccccccucgggggggccgggccaccccucccacggcgcgaccgcuggggcggacuguccagugcgccccgggcgggucgcgccgucgggcccggggggccacgcgucccccgcgagcgcacggggucggcggcgaugucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcuacgaaagccgccguggcgcaaugaaggugaaggccggcggcgcgccgccggccgaggugggaucccgaggccuuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcgaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccaaaguuucccucaggauagcuggcgcucuccgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcugguguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggaugguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgcuggcagucggcagagcgagaaagagaguggcgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucagccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcuggcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacguuuuuucacugacccggugaggcgggggggcgagccgggcucucgcuucuggcgccaagcgcccggccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauagcgccggagccucgguuggccucggauagccggucccccgccgggguccggugcggagagcccuucgucccgggaaacggggcggccggaaagggggccgcccucucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcugcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<...<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>...<<<<<<<<<....<<<<<<<<..<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>...>>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<......>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<<....<<<<<<<.<<<<<.<<<<<<<.<<<<<<<<<......>>>>>>>>>>>>>>>>>>>>>>>>>...>>>.>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<<<<<<<<<<<<<<<<<...<<..<<<..<<<<<<<......<<<<<<<<.>>>>>>>>.......>>>>>>>..>>>.........>>>>>>..>>>>>>>>>>>.....<<.......>>.........<...<<<<<<..>>>>>>....<<<...<<.<<<<<<<<<<<<<<<<<<<<<<<.<<<<..>>>>.>>>>>>.>>>.>>>>>>>>>>>.>>>...>>.>>.>................>........>>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<.....>>>>.....>>>...<<....>>...<<<<<<<<<<..>>>>>>>>>>..<<<<<...<<<..<<<...(((.[..>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<...<<<.<<<<<<<<<...<<<....<<<..<.<<<..<<<<.<.........>.>>>>>>>.>..>>>..>>.>...>>>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<......<..........<<<.<<<<<<<<<<.......<<<<<.<<.....................>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>....>>>>>..>>>...>>>>>>><<<<<<.<<<.....................].)))............>>>>>>>>>....>>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<<<<<...>>>>>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<...<<<<<<<....>>>>>>>...<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<...............>>>>><<.<<<<<<<<<<<.>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<<....>>>>>>>>...<<<<<.....<<<<..<<.<<<<<>>.>>>>>..............<<<<<<<<<..>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.((.((>>....>>>>>>>...<<<..<<<<.......>>>>..>>>.<<<....>>>.>>)))).....<<<<<<<..<<<..)))))).>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<.]]]..>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.<<<<<<...<<<<....<<<........<<<<<...<<<<.>>>>..>>>>>.......>>>...<<<..<<<<....<<<<<<<<<........>>>>>>.>>>...>>>>..>>>..............>>>>....>>>>>>.<<<<<.<.............>....<<.<<<<<<<.<<.....<<<<.<..<<<<<.>>>>>..>>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..(((((((((((.....)))))).))))....))))....(((((((((....((((((((.(((((((((..({((((......)))))....[[(...).(((....}]])))...).)))))))..)))))))))...)))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...(((((((..(((.....((((((((((.(..(((((((.(((((.(((((((.((.(((((.(.()..)))))).))))))))))))))))))...))))))))))))))......)))..)).)))))...(((((((((((((((((((((((...((..(((..(((((((.......(((((((.)))))))........)))))))..))).........))))))..))))))))))).....((.....{.))...........(.((((((()))))))....(((...((.(((((((((((((((((((((((.((((..)))).)))))).))).))))))))))).)))...)).)).)............[.)..........))).)))))...)))))...)))))))).<((((........))))((((((....(((((((((((((..(((..(((((.....))))..)..)))...((....))...((.(((((((()))))))).))..(((((...(((..(((]..[[..[.[)))..)))....))))).(((((((((.((((......))))))))))).))....)))))))))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)<)))...(((..((.((.......B)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((...(((.((((((((....(((....(((..(.(((..(((((..(.....)..)))))))).)..)))..)).)....))))))...(((((((((.(......))))))))))....))))))))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.....A.(((((.(((....(.........)....))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((........}.........]..]..]]............)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...((..(.(((....))).....)....((.(((((((((...)))))))))))......))....))...(((((........)))))]]((((....(((((...(((((((....)))))))..((((....)))...(...((((((...(((((((((((((((((((((((...{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....(((((((.......))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((.)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(..(((.....(((.....).)).....))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.(((((((((.(((((((......)))))))...(((((.....((((..(..(..(())...).)..............(((((.(((()))).)))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(.(((.(((((....{..)))).)))))(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..b.))..))).))))).....(((((..(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}..)))))..)).))...))))...)))).((((...((((.....a.......))))...))))..)))...).).)))).(((((((...(((....(((.........((((...((((.))))..))))........)))...(((..(((.....(((.(((((........)))))..)))....)))..)))..............)))...).)))))).(((((.(..(.......)..)....((.(((((((.((.....((((.(..(((((.)))))..)))))....))....)))).))).))..))))).. Structure of the mammalian ribosomal termination complex with accommodated eRF1(AAQ) and ABCE1.; 28S ribosomal RNA 5lzv 7 120 3.35 RF00001 URS000002B0D5_9986 27863242 0003735 0005840 9986 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. Structure of the mammalian ribosomal termination complex with accommodated eRF1(AAQ) and ABCE1.; 5S ribosomal RNA 5lzv 8 151 3.35 RF00002 URS00004B2C76_9986 27863242 0003735 0005840 9986 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcagguugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<.<<.....>>>.....(.<<<......>>........>>>..)...>>>....<<<..>>><<<<<<<<.......>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]]........)))..)...)))....((....))((((((((.......)))))))).................... Structure of the mammalian ribosomal termination complex with accommodated eRF1(AAQ) and ABCE1.; 5.8S ribosomal RNA 5lzv 9 1698 3.35 RF01960,RF01959,RF00177 URS0000A7639A_9986 27863242 0003735 0005840 9986 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucguacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgcccggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcggccguccccugcucggcgccggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgaccccggucggcguaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggugcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<....<<....<<<<..........<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<<<....>>>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<<.>>>>>>>>..>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....<<<<<<<<<.<<<....>>>..>>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<....<<<.<<<..>>>.>>><<<<<<<.<<..>>>>>>.>>>.<<<<<<.<.......<<...<.......>.<<<<.>>>>...>>......>.>>>..>>>........<.<<.<<<<<<<...............>>>>>>>.>>.>....>>....<<<<<<..<...<<<<..<<<.<<<<<<<<...<<<......>>>......>>>>>>>>.>>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<..>>>>.>>>>>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<...<.<<<<<..........>>>>>>....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<.<<<<<<<<<..>>>>>>>>>...>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..((....((((....(([...((.....((.(((.....))).))......))......)).((((...((((((....))))))...))))((..(((((...(......)..)))))......)).(]((((.(((...)))))))).).)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).).....(((((((((.((......))..)))))).)))....(.((..(...........)..))......)..((((([[......((((.....((..]])).......)))).)))))..)))))).)))..[......(.([[...(.(.((...(((..(....(((.(((())).)))).((((((.((())))))).))..((((((.(.......((..((.......)).(((.)))....))......).)))..)))........(.((.(((((((...............))))))).)).)....)....((((.(...(...((((..(((.((((((((...((........))......)))))))).))).......((....))...))))..)...)..)))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.(((((....))))))))))).)..)))...((..]]))...))...].))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((..((........))..))....).)))))...((.(((...(.((((((.(..(((.(((((....)))..(.((......)))...)).)))....(((...(...(((...((((((((((((..)))).))))))))..).))..).....(((((.....)))))........))).)..))).))).....).))))).....).)))))...)).)))).))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..((((.((...(((((((((((((((..))))))))).).)))))...)).))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}........ Structure of the mammalian ribosomal termination complex with accommodated eRF1(AAQ) and ABCE1.; 18S ribosomal RNA 5lzv hh 15 3.35 27863242 9986 ucaaaguuugagcuc ............... ............... Structure of the mammalian ribosomal termination complex with accommodated eRF1(AAQ) and ABCE1.; mRNA (UGA stop codon) 5lzw 2 76 3.53 RF00005 URS0000868530_9986 27863242 0030533 9986 gucuccguaguguagcgguuaucacguucgccuaacacgcgaaagguccucgguucgaaaccgggcggaaacacca <<.<<<<..<<<..........>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>.>>.... ((.((((..(((.....[....))).(((((.......))))).....(((((..]....))))))))).)).... Structure of the mammalian rescue complex with Pelota and Hbs1l assembled on a truncated mRNA.; P-site tRNA 5lzw 3 75 3.53 RF00005 URS000086855F_9986 27863242 0030533 0006412 9986 gcccggauagcucagcuguagagcaucagacuuuuaaucugaggguccaggguucaagucccuguucgggcgcca <<<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... ((((.((..((((....[..)))).(((((.......))))).....(((((..]....))))))).)))).... Structure of the mammalian rescue complex with Pelota and Hbs1l assembled on a truncated mRNA.; E-site tRNA 5lzw 5 3543 3.53 RF02540,RF02543 URS0000A7632C_9986 27863242 0003735 0005840 9986 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggaaauguggcguacggaagacccacuccccggcgccggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcgcgguccggccgugccggcggggcggaucucccgcucccgucggcgggggaccgccccccggccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggccccggcggggaagguggcccgggggccccggguguuacagccccgccccggcagcagcagcucgccgaaucccggggccgagggagcgagacccgugcgccgcgcucuccccccucgggggggccgggccaccccucccacggcgcgaccgcuggggcggacuguccagugcgccccgggcgggucgcgccgucgggcccggggggccacgcgucccccgcgagcgcacggggucggcggcgaugucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcuacgaaagccgccguggcgcaaugaaggugaaggccggcggcgcgccgccggccgaggugggaucccgaggccuuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcgaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccaaaguuucccucaggauagcuggcgcucuccgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcugguguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggaugguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgcuggcagucggcagagcgagaaagagaguggcgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucagccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcuggcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacguuuuuucacugacccggugaggcgggggggcgagccgggcucucgcuucuggcgccaagcgcccggccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauagcgccggagccucgguuggccucggauagccggucccccgccgggguccggugcggagagcccuucgucccgggaaacggggcggccggaaagggggccgcccucucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcugcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>>..<<<<<<<<<....<<<<<<<<..<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>...>>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<.....<<<<<<<.<<<<<.<<<<<<<.<<<<<<<<<......>>>>>>>>>>>>>>>>>>>>>>>>>...>>>..>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<<<<<<<<<<<<<<<<<...<<..<<<..<<..<<<......<<<<<<<<.>>>>>>>>.......>>>..>>..>>>.........>>>>>>..>>>>>>>>>>>......<.......>..........<...<<<<<<..>>>>>>....<<<...<<.<<<<<<<<<<<<<<<<<<<<<<<.<<<<..>>>>.>>>>>>.>>>.>>>>>>>>>>>.>>>...>>.>>.>................>........>>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<.....>>>>.....>>>...<<....>>...<<<<<<..<....>..>>>>>>..<<<<<...<<<..<<<...(((.[[.>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<...<<<.<<<<<<<<<...<<<....<<<....<<<..<<<<.<.........>.>>>>>>>....>>>..>.>>...>>>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<......<..........<<<.<<<<<<<<<<.......<<<<<.<<.....................>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>....>>>>>..>>>...>>>>>>><<<<<<.<<<....................]].)))............>>>>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<<<<<...>>>>>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<...<<<<<<<....>>>>>>>...<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<...............>>>>><<.<<<<<<<<<<<.>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<<....>>>>>>>>...<<<<<.....<<<<..<<.<<<<<>>.>>>>>..............<<<<<<<<<..>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.((.((>>....>>>>>>>...<<<..<<<<.......>>>>..>>>.<<<....>>>.>>)))).....<<<<<<<..<<<..)))))).>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.<.....>.>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<]]].>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.<<<<<<...<<<<....<<<........<<<<<..<<<<<.>>>>>.>>>>>.......>>>...<<<..<<<<....<<<<<<<<<........>>>>>>.>>>...>>>>..>>>..............>>>>....>>>>>>.<<<<<....................<<.<<<<<<<.<<.....<<<<....<<<<<.>>>>>...>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..(((((((((((.....)))))).))))....))))....(((((((((....((((((((.(((((((((..({((((......)))))....[[(...).(((....}]])))...).)))))))..)))))))))...)))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....(((((((((..(..(((((((.(((((.(((((((.((.(((((...()...))))).))))))))))))))))))...)))).)))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((..((..(((.......(((((((.)))))))........))))..)..))).........))))))..)))))))))))......(.....{.)............(.((((((()))))))...(.((...((.(((((((((((((((((((((((.((((..)))).)))))).))).))))))))))).)))...)).)).)............[.)..........))).)))))...)))))...)))))))).<((((........))))((((((..(.(((((((((((((..(((..(((((.....))))..)..)))...((....))...((.((((.(....).)))).))..(((((...(((..(((]..[[..[.[)))..)))....))))).(((((((((.((((......))))))))))).))....)))))))))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))....))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((.(((((((...(((.((((((((....(((....(((..(.(((..(((.(..(.....)...))))))).)..)))..)).)....))))))...(((((((((.(......))))))))))....))))))))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((.(.......(((((.(((....(.........)....))).....(...((......)).).)))))...).)))))))))))..........]]].)....))))))))))...)))))))((((((.(((........}.........]..]..]]............)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...((..(.(((....))).....)....((.(((((((((...)))))))))))......))....))...(((((........)))))]]((((....(((((...(((((((....)))))))..((((....)))...(...((((((...(((((((((((((((((((((((...{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((.)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(..(((.....(((.....).)).....))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.(((((((((.(((((((......)))))))...(((((.....((((..(..(..(())...).)..............(((((.(((()))).)))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(.(((((......)))))...).)..((.(.....).))......)))))..)...))).).....(((((((....))).))))..a.))..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}..)))))..)).))...))))...)))).((((...((((.............))))...))))..)))...).)))))).(((((((...(((....(((.........((((...((((.))))..))))........)))...(((..(((.....(((.(((((........)))))..)))....)))..)))..............)))...).)))))).(.(((.(..(.......)..)....((.(((((((.((.....((((.(..(((((.)))))..)))))....))....)))).))).))..))))... Structure of the mammalian rescue complex with Pelota and Hbs1l assembled on a truncated mRNA.; 28S ribosomal RNA 5lzw 7 120 3.53 RF00001 URS000002B0D5_9986 27863242 0003735 0005840 9986 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. Structure of the mammalian rescue complex with Pelota and Hbs1l assembled on a truncated mRNA.; 5S ribosomal RNA 5lzw 8 151 3.53 RF00002 URS00004B2C76_9986 27863242 0003735 0005840 9986 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcagguugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<<<<....>>>>.....<.<<<......>>........>>>..>...>>>....<<<..>>><<<<<<<<.......>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]]........)))..)...)))....((....))((((((((.......)))))))).................... Structure of the mammalian rescue complex with Pelota and Hbs1l assembled on a truncated mRNA.; 5.8S ribosomal RNA 5lzw 9 1698 3.53 RF01960,RF01959,RF00177 URS0000A7639A_9986 27863242 0003735 0005840 9986 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucguacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgcccggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcggccguccccugcucggcgccggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgaccccggucggcguaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggugcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<....<<....<<<<..........<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<<<....>>>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<<.>>>>>>>>..>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....<<<<<<<<<.<<<....>>>..>>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<....<<<.<<<..>>>.>>><<<<<<<.<<..>>>>>>.>>>.<<<<<<.<.......<<...<.......>.<<<<.>>>>...>>......>.>>>..>>>........<.<<.<<<<<<<...............>>>>>>>.>>.>....>>....<<<<<<..<...<<<<..<<<.<<<<<<<<...<<<......>>>......>>>>>>>>.>>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<..>>>>.>>>>>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<<<<<<<<<<<..>>>>>>>>>.>.>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..((....((((....(([...((.....((.(((.....))).))......))......)).((((...((((((....))))))...))))((..(((((...(......)..)))))......)).(]((((..((...)).))))).).)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).).....(((((((((.((......))..)))))).)))....(.((..(...........)..))......)..((((([[....(.((((.....((..]])).......))))))))))..)))))).)))..[......(.([[...(.(.((...(((..(....(((.(((())).)))).((((((.((())))))).))..((((((.(.......((..((.......)).(((.)))....))......).)))..)))........(.((.(((((((...............))))))).)).)....)....((((.(...(...((((..(((.((((((((...((........))......)))))))).))).......((....))...))))..)...)..)))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.(((((....))))))))))).)..)))...((..]]))...))...].))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((..((........))..))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((...(...((((..((((((((((((..)))).))))))))..))))..).....(((((.....)))))........)))....))).))).....).))))).....).)))))...)).)))).))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..((((.((...(((((((((((((((..))))))))).).)))))...)).))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}........ Structure of the mammalian rescue complex with Pelota and Hbs1l assembled on a truncated mRNA.; 18S ribosomal RNA 5lzx 2 76 3.67 RF00005 URS0000868530_9986 27863242 0030533 9986 gucuccguaguguagcgguuaucacguucgccuaacacgcgaaagguccucgguucgaaaccgggcggaaacacca <<.<<<<..<<<..........>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>.>>.... ((.((((..(((.....[....))).(((((.......))))).....(((((..]....))))))))).)).... Structure of the mammalian rescue complex with Pelota and Hbs1l assembled on a UGA stop codon.; P-site tRNA 5lzx 3 75 3.67 RF00005 URS000086855F_9986 27863242 0030533 0006412 9986 gcccggauagcucagcuguagagcaucagacuuuuaaucugaggguccaggguucaagucccuguucgggcgcca <<<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... ((((.((..((((....[..)))).(((((.......))))).....(((((..]....))))))).)))).... Structure of the mammalian rescue complex with Pelota and Hbs1l assembled on a UGA stop codon.; E-site tRNA 5lzx 5 3543 3.67 RF02540,RF02543 URS0000A7632C_9986 27863242 0003735 0005840 9986 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggaaauguggcguacggaagacccacuccccggcgccggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcgcgguccggccgugccggcggggcggaucucccgcucccgucggcgggggaccgccccccggccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggccccggcggggaagguggcccgggggccccggguguuacagccccgccccggcagcagcagcucgccgaaucccggggccgagggagcgagacccgugcgccgcgcucuccccccucgggggggccgggccaccccucccacggcgcgaccgcuggggcggacuguccagugcgccccgggcgggucgcgccgucgggcccggggggccacgcgucccccgcgagcgcacggggucggcggcgaugucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcuacgaaagccgccguggcgcaaugaaggugaaggccggcggcgcgccgccggccgaggugggaucccgaggccuuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcgaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccaaaguuucccucaggauagcuggcgcucuccgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcugguguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggaugguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgcuggcagucggcagagcgagaaagagaguggcgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucagccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcuggcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacguuuuuucacugacccggugaggcgggggggcgagccgggcucucgcuucuggcgccaagcgcccggccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauagcgccggagccucgguuggccucggauagccggucccccgccgggguccggugcggagagcccuucgucccgggaaacggggcggccggaaagggggccgcccucucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcugcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<...<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>...<<<<<<<<<....<<<<<<<<..<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>...>>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<.....<<<<<<<.<<<<<.<<<<<<<.<<<<<<<<<......>>>>>>>>>>>>>>>>>>>>>>>>>...>>>..>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<<<<<<<<<<<<<<<<<...<<..<<<..<<..<<<......<<<<<<<<.>>>>>>>>.......>>>..>>..>>>.........>>>>>>..>>>>>>>>>>>......<.......>..........<...<<<<<<..>>>>>>...<.<<...<<.<<<<<<<<<<<<<<<<<<<<<<<.<<<<..>>>>.>>>>>>.>>>.>>>>>>>>>>>.>>>...>>.>>.>................>........>>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<<<<...<<<<<<<<<<<<<<..<<<...<<<<.....>>>>.....>>>...<<....>>...<<<<<<..<....>..>>>>>>..<<<<<...<<<..<<<...(((.[[.>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>>.<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<...<<<.<<<<<<<<<...<<<....<<<..<.<<<..<<<<.<.........>.>>>>>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<.....................>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<....................]].)))............>>>>>>>>>....>>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<<<<<...>>>>>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<...<<<<<<<....>>>>>>>...<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<.<<<<<<<<<<<.>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<<....>>>>>>>>...<<<<<.....<<<<..<<.<<<<<>>.>>>>>..............<<<<<<<<<..>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>>.<<<....>>>.>>)))].....<<<<<<<..<<<..)))))).>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<]]].>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.<<<<<<...<<<<....<<<........<<<<<..<<<<<.>>>>>.>>>>>.......>>>...<<<..<<<<....<<<<<<<<<........>>>>>>.>>>...>>>>..>>>..............>>>>....>>>>>>.<<<<<.<.............>....<<.<<<<<<<.<<.....<<<<.<..<<<<<.>>>>>..>>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..(((((((((((.....)))))).))))....))))....(((((((((....((((((((.(((((((((..({((((......)))))....[[(...).(((....}]])))...).)))))))..)))))))))...)))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....(((((((((..(..(((((((.(((((.(((((((.((.(((((...()...))))).))))))))))))))))))...)))).)))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((..((..(((.......(((((((.)))))))........))))..)..))).........))))))..)))))))))))......(.....{.)............(.((((((()))))))...(.((...((.(((((((((((((((((((((((.((((..)))).)))))).))).))))))))))).)))...)).)).)............[.)..........))).)))))...)))))...)))))))).<((((........))))((((((..(.(((((((((((((..(((..(((((.....))))..)..)))...((....))...(((((((.(....).)))))))..(((((...(((..(((]..[[..[.[)))..)))....))))).(((((((((.((((......))))))))))).))....)))))))))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))....))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((.(((((((...(((.((((((((....(((....(((..(.(((..(((.(..(.....)...))))))).)..)))..)).)....))))))...(((((((((.(......))))))))))....))))))))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.......(((((.(((....(.........)....))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((........}.........]..]..]]............)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...((..(.(((....))).....)....((.(((((((((...)))))))))))......))....))...(((((........)))))]]((((....(((((...(((((((....)))))))..((((....)))...(...((((((...(((((((((((((((((((((((...{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((.)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(..(((.....(((.....).)).....))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.(((((((((.(((((((......)))))))...(((((.....((((..(..(..(())...).)..............(((((.(((()))).)))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(.(((.(((((....{..)))).)))))(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a.))..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}..)))))..)).))...))))...)))).((((...((((.............))))...))))..)))...).)))))).(((((((...(((....(((.........((((...((((.))))..))))........)))...(((..(((.....(((.(((((........)))))..)))....)))..)))..............)))...).)))))).(.(((.(..(.......)..)....((.(((((((.((.....((((.(..(((((.)))))..)))))....))....)))).))).))..))))... Structure of the mammalian rescue complex with Pelota and Hbs1l assembled on a UGA stop codon.; 28S ribosomal RNA 5lzx 7 120 3.67 RF00001 URS000002B0D5_9986 27863242 0003735 0005840 9986 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. Structure of the mammalian rescue complex with Pelota and Hbs1l assembled on a UGA stop codon.; 5S ribosomal RNA 5lzx 8 151 3.67 RF00002 URS00004B2C76_9986 27863242 0003735 0005840 9986 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcagguugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<<<<....>>>>.....<.<<<......>>........>>>..>...>>>....<<<..>>><<<<<<<<.......>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]]........)))..)...)))....((....))((((((((.......)))))))).................... Structure of the mammalian rescue complex with Pelota and Hbs1l assembled on a UGA stop codon.; 5.8S ribosomal RNA 5lzx 9 1698 3.67 RF01960,RF01959,RF00177 URS0000A7639A_9986 27863242 0003735 0005840 9986 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucguacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgcccggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcggccguccccugcucggcgccggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgaccccggucggcguaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggugcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<....<<....<<<<..........<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<<<....>>>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<<.>>>>>>>>..>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....<<<<<<<<<.<<<....>>>..>>>>>>.>>>......<<..<...........>..>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<....<<<.<<<..>>>.>>><<<<<<<.<<..>>>>>>.>>>.<<<<<<.<.......<<...<.......>.<<<<.>>>>...>>......>.>>>..>>>........<.<<.<<<<<<<...............>>>>>>>.>>.>....>>....<<<<<<..<...<<<<..<<<.<<<<<<<<...<<<......>>>......>>>>>>>>.>>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<<....>>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<..>>>>.>>>>>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<...<.<<<<<..........>>>>>>....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<<<<<<<<<<<..>>>>>>>>>.>.>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..((....((((....(([...((.....((.(((.....))).))......))......)).((((...((((((....))))))...))))((..(((((...(......)..)))))......)).(]((((..((...)).))))).).)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).).....(((((((((.((......))..)))))).)))....(.((..(...........)..))......)..((((([[....(.((((.....((..]])).......))))))))))..)))))).)))..[......(.([[...(.(.((...(((..(....(((.(((())).)))).((((((.((())))))).))..((((((.(.......((..((.......)).(((.)))....))......).)))..)))........(.((.(((((((...............))))))).)).)....)....((((.(...(...((((..(((.((((((((...((........))......)))))))).))).......((....))...))))..)...)..)))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.(((((....))))))))))).)..)))...((..]]))...))...].))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((..((........))..))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((...(...(((...((((((((((((..)))).))))))))..).))..).....(((((.....)))))........)))....))).))).....).))))).....).)))))...)).)))).))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..((((.((...(((((((((((((((..))))))))).).)))))...)).))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}........ Structure of the mammalian rescue complex with Pelota and Hbs1l assembled on a UGA stop codon.; 18S ribosomal RNA 5lzy 2 75 3.99 RF00005 URS000086855F_9986 27863242 0030533 0006412 9986 gcccggauagcucagcuguagagcaucagacuuuuaaucugaggguccaggguucaagucccuguucgggcgcca <<<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... ((((.((..((((....[..)))).(((((.......))))).....(((((..]....))))))).)))).... Structure of the mammalian rescue complex with Pelota and Hbs1l assembled on a polyadenylated mRNA.; tRNA 5lzy 3 75 3.99 RF00005 URS000086855F_9986 27863242 0030533 0006412 9986 gcccggauagcucagcuguagagcaucagacuuuuaaucugaggguccaggguucaagucccuguucgggcgcca <<<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... ((((.((..((((....[..)))).(((((.......))))).....(((((..]....))))))).)))).... Structure of the mammalian rescue complex with Pelota and Hbs1l assembled on a polyadenylated mRNA.; tRNA 5lzy 5 3543 3.99 RF02540,RF02543 URS0000A7632C_9986 27863242 0003735 0005840 9986 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggaaauguggcguacggaagacccacuccccggcgccggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcgcgguccggccgugccggcggggcggaucucccgcucccgucggcgggggaccgccccccggccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggccccggcggggaagguggcccgggggccccggguguuacagccccgccccggcagcagcagcucgccgaaucccggggccgagggagcgagacccgugcgccgcgcucuccccccucgggggggccgggccaccccucccacggcgcgaccgcuggggcggacuguccagugcgccccgggcgggucgcgccgucgggcccggggggccacgcgucccccgcgagcgcacggggucggcggcgaugucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcuacgaaagccgccguggcgcaaugaaggugaaggccggcggcgcgccgccggccgaggugggaucccgaggccuuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcgaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccaaaguuucccucaggauagcuggcgcucuccgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcugguguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggaugguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgcuggcagucggcagagcgagaaagagaguggcgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucagccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcuggcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacguuuuuucacugacccggugaggcgggggggcgagccgggcucucgcuucuggcgccaagcgcccggccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauagcgccggagccucgguuggccucggauagccggucccccgccgggguccggugcggagagcccuucgucccgggaaacggggcggccggaaagggggccgcccucucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcugcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<<...<<<<<<<<<<<...>>>>>>>.>>>>.....>>>>>..<<<<<<<<<....<<<<<<<<..<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>...>>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<.....<<<<<<<.<<<<<.<<<<<<<.<<<<<<<<<......>>>>>>>>>>>>>>>>>>>>>>>>>...>>>..>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<<<<<<<<<<<<.<<<<...<<..<<<...<..<<<......<<<<<<<<.>>>>>>>>.......>>>..>...>>>.........>>>>>>...>>>>>>>>>>......<.......>..........<...<<<<<<..>>>>>>...<.<<...<<.<<<<<<<<<<<<<<<<<<<<<<<.<<<<..>>>>.>>>>>>.>>>.>>>>>>>>>>>.>>>...>>.>>.>................>........>>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<.....>>>>.....>>>...<<....>>...<<<<<<..<....>..>>>>>>..<<<<<...<<<..<<<...(((.[[.>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<...<<<.<<<<<<<<<...<<<....<<<..<.<<<..<<<<.<.........>.>>>>>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<.....................>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<....................]].)))............>>>>>>>>>....>>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<<<<<...>>>>>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<...<<<<<<<....>>>>>>>...<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<...............>>>>><<.<<<<<<<<<<<.>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<<....>>>>>>>>...<<<<<.....<<<<..<<.<<<<<>>.>>>>>..............<<<<<<<<<..>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>>.<<<....>>>.>>)))].....<<<<<<<..<<<..)))))).>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>.>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<]]].>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.<<<<<<...<<<<....<<<........<<<<<..<<<<<.>>>>>.>>>>>.......>>>...<<<..<<<<....<<<<<<<<<........>>>>>>.>>>...>>>>..>>>..............>>>>....>>>>>>.<<<<<.<.............>....<<.<<<<<<<.<<.....<<<<....<<<<<.>>>>>...>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..(((((((((((.....)))))).))))....))))....(((((((((....((((((((.(((((((((..({((((......)))))....[[(...).(((....}]])))...).)))))))..)))))))))...)))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....(((((((((..(..(((((((.(((((.(((((((.((.(((((...()...))))).))))))))))))))))))...)))).)))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((..(...(((.......(((((((.)))))))........)))...)..))).........))))))..)))))))))))......(.....{.)............(.((((((()))))))...(.((...((.(((((((((((((((((((((((.((((..)))).)))))).))).))))))))))).)))...)).)).)............[.)..........))).)))))...)))))...)))))))).<((((........))))((((((..(.(((((((((((((..(((..(((((.....))))..)..)))...((....))...(((((((.(....).)))))))..(((((...(((..(((]..[[..[[[)))..)))....))))).(((((((((.((((......))))))))))).))....)))))))))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)<)))...(((..((.((.......B)))).)))....))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((.(((((((...(((.((((((((....(((....(((..(.(((..(((((..(.....)..)))))))).)..)))..)).)....))))))...(((((((((.(......))))))))))....))))))))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.....A.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((........}.........].]]..]]............)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...((..(.(((....))).....)....((.(((((((((...)))))))))))......))....))...(((((........)))))]]((((....(((((...(((((((....)))))))..((((....)))...(...((((((...(((((((((((((((((((((((...{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((.)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(..(((.....(((.....).)).....))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.(((((((((.((((((((....))))))))...(((((.....((((..(..(..(())...).)..............(((((.(((()))).)))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..b.))..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}..)))))..)).))...))))...)))).((((...((((.....a.......))))...))))..)))...).)))))).(((((((...(((....(((.........((((...((((.))))..))))........)))...(((..(((.....(((.(((((........)))))..)))....)))..)))..............)))...).)))))).(.(((.(..(.......)..)....((.(((((((.((.....((((.(..(((((.)))))..)))))....))....)))).))).))..))))... Structure of the mammalian rescue complex with Pelota and Hbs1l assembled on a polyadenylated mRNA.; 28S ribosomal RNA 5lzy 7 120 3.99 RF00001 URS000002B0D5_9986 27863242 0003735 0005840 9986 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. Structure of the mammalian rescue complex with Pelota and Hbs1l assembled on a polyadenylated mRNA.; 5S ribosomal RNA 5lzy 8 151 3.99 RF00002 URS00004B2C76_9986 27863242 0003735 0005840 9986 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcagguugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<.<<.....>>>.....(.<<<......>>........>>>..)...>>>....<<<..>>><<<<<<<<.......>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]]........)))..)...)))....((....))((((((((.......)))))))).................... Structure of the mammalian rescue complex with Pelota and Hbs1l assembled on a polyadenylated mRNA.; 5.8S ribosomal RNA 5lzy 9 1698 3.99 RF01960,RF01959,RF00177 URS0000A7639A_9986 27863242 0003735 0005840 9986 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucguacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgcccggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcggccguccccugcucggcgccggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgaccccggucggcguaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggugcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<....<<....<<<<<.........<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<<<....>>>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<<.>>>>>>>>.>>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....<<<<<<<<<.<<<....>>>..>>>>>>.>>>......<<..<...........>..>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<....<<<.<<<..>>>.>>><<<<<<<.<<..>>>>>>.>>>.<<<<<<.<.......<<...<.......>.<<<<.>>>>...>>......>.>>>..>>>........<.<<.<<<<<<<...............>>>>>>>.>>.>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<<....>>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<..>>>>.>>>>>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<...<.<<<<<..........>>>>>>....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<<<<<<<<<<<..>>>>>>>>>.>.>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..((....((((....(([...((.....((.(((.....))).))......))......)).((((...((((((....))))))...))))((..(((((...(......)..)))))......)).(]((((..((...)).))))).).)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).).....(((((((((.((......))..)))))).)))....(.((..(...........)..))......)..((((([[....(.((((.....((..]])).......))))))))))..)))))).)))..[......(.([[...(.(.((...(((..(....(((.(((())).)))).((((((.((())))))).))..((((((.(.......((..((.......)).(((.)))....))......).)))..)))........(.((.(((((((...............))))))).)).)....)....((((.(...(...((((..((..((((((((...((........))......))))))))..)).......((....))...))))..)...)..)))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.(((((....))))))))))).)..)))...((..]]))...))...].))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((..((........))..))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((...(...(((...((((((((((((..)))).))))))))..).))..).....(((((.....)))))........)))....))).))).....).))))).....).)))))...)).)))).))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..((((.((...(((((((((((((((..))))))))).).)))))...)).))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}........ Structure of the mammalian rescue complex with Pelota and Hbs1l assembled on a polyadenylated mRNA.; 18S ribosomal RNA 5lzz 2 76 3.47 RF00005 URS0000868530_9986 27863242 0030533 9986 gucuccguaguguagcgguuaucacguucgccuaacacgcgaaagguccucgguucgaaaccgggcggaaacacca <<.<<<<..<<<..........>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>.>>.... ((.((((..(((.....[....))).(((((.......))))).....(((((..]....))))))))).)).... Structure of the mammalian rescue complex with Pelota and Hbs1l (combined); P-site tRNA 5lzz 3 75 3.47 RF00005 URS000086855F_9986 27863242 0030533 0006412 9986 gcccggauagcucagcuguagagcaucagacuuuuaaucugaggguccaggguucaagucccuguucgggcgcca <<<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... ((((.((..((((....[..)))).(((((.......))))).....(((((..]....))))))).)))).... Structure of the mammalian rescue complex with Pelota and Hbs1l (combined); E-site tRNA 5lzz 5 3543 3.47 RF02540,RF02543 URS0000A7632C_9986 27863242 0003735 0005840 9986 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggaaauguggcguacggaagacccacuccccggcgccggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcgcgguccggccgugccggcggggcggaucucccgcucccgucggcgggggaccgccccccggccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggccccggcggggaagguggcccgggggccccggguguuacagccccgccccggcagcagcagcucgccgaaucccggggccgagggagcgagacccgugcgccgcgcucuccccccucgggggggccgggccaccccucccacggcgcgaccgcuggggcggacuguccagugcgccccgggcgggucgcgccgucgggcccggggggccacgcgucccccgcgagcgcacggggucggcggcgaugucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcuacgaaagccgccguggcgcaaugaaggugaaggccggcggcgcgccgccggccgaggugggaucccgaggccuuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcgaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccaaaguuucccucaggauagcuggcgcucuccgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcugguguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggaugguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgcuggcagucggcagagcgagaaagagaguggcgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucagccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcuggcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacguuuuuucacugacccggugaggcgggggggcgagccgggcucucgcuucuggcgccaagcgcccggccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauagcgccggagccucgguuggccucggauagccggucccccgccgggguccggugcggagagcccuucgucccgggaaacggggcggccggaaagggggccgcccucucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcugcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>>..<<<<<<<<<....<<<<<<<<..<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>...>>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<.....<<<<<<<.<<<<<.<<<<<<<.<<<<<<<<<......>>>>>>>>>>>>>>>>>>>>>>>>>...>>>..>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<<<<<<<<<<<<<<<<<...<<..<<<...<..<<<......<<<<<<<<.>>>>>>>>.......>>>..>...>>>.........>>>>>>..>>>>>>>>>>>......<.......>..........<...<<<<<<..>>>>>>...<.<<...<<.<<<<<<<<<<<<<<<<<<<<<<<.<<<<..>>>>.>>>>>>.>>>.>>>>>>>>>>>.>>>...>>.>>.>................>........>>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<<<<...<<<<<<<<<<<<<<..<<<...<<<<.....>>>>.....>>>...<<....>>...<<<<<<..<....>..>>>>>>..<<<<<...<<<..<<<...(((.[[.>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>>.<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<...<<<.<<<<<<<<<...<<<....<<<..<.<<<..<<<<.<.........>.>>>>>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<.....................>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<....................]].)))............>>>>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<<<<<...>>>>>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<...<<<<<<<....>>>>>>>...<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<...............>>>>><<.<<<<<<<<<<<.>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<<....>>>>>>>>...<<<<<.....<<<<..<<.<<<<<>>.>>>>>..............<<<<<<<<<..>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>><<<<....>>>>>>)))].....<<<<<<<..<<<..)))))).>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>.>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<]]].>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.<<<<<<...<<<<....<<<........<<<<<..<<<<<.>>>>>.>>>>>.......>>>...<<<..<<<<....<<<<<<<<<........>>>>>>.>>>...>>>>..>>>..............>>>>....>>>>>>.<<<<<.<.............>....<<.<<<<<<<.<<.....<<<<.<..<<<<<.>>>>>..>>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..(((((((((((.....)))))).))))....))))....(((((((((....((((((((.(((((((((..({((((......)))))....[[(...).(((....}]])))...).)))))))..)))))))))...)))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....(((((((((..(..(((((((.(((((.(((((((.((.(((((...()...))))).))))))))))))))))))...)))).)))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((..(...(((.......(((((((.)))))))........)))...)..))).........))))))..)))))))))))......(.....{.)............(.((((((()))))))...(.((...((.(((((((((((((((((((((((.((((..)))).)))))).))).))))))))))).)))...)).)).)............[.)..........))).)))))...)))))...)))))))).<((((........))))((((((..(.(((((((((((((..(((..(((((.....))))..)..)))...((....))...(((((((.(....).)))))))..(((((...(((..(((]..[[..[[[)))..)))....))))).(((((((((.((((......))))))))))).))....)))))))))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)<)))...(((..((.((.......B)))).)))....))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((.(((((((...(((.((((((((....(((....(((..(.(((..(((((..(.....)..)))))))).)..)))..)).)....))))))...(((((((((.(......))))))))))....))))))))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.....A.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((........}.........].]]..]]............)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...((..(.(((....))).....)....((.(((((((((...)))))))))))......))....))...(((((........)))))]]((((....(((((...(((((((....)))))))..((((....)))...(...((((((...(((((((((((((((((((((((...{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((.)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(..(((.....(((.....).)).....))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.(((((((((.((((((((....))))))))...(((((.....((((..(..(..(())...).)..............(((((.(((()))).)))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..b.))..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}..)))))..)).))...))))...)))).((((...((((.....a.......))))...))))..)))...).)))))).(((((((...(((....(((.........((((...((((.))))..))))........)))...(((..(((.....(((.(((((........)))))..)))....)))..)))..............)))...).)))))).(.(((.(..(.......)..)....((.(((((((.((.....((((.(..(((((.)))))..)))))....))....)))).))).))..))))... Structure of the mammalian rescue complex with Pelota and Hbs1l (combined); 28S ribosomal RNA 5lzz 7 120 3.47 RF00001 URS000002B0D5_9986 27863242 0003735 0005840 9986 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. Structure of the mammalian rescue complex with Pelota and Hbs1l (combined); 5S ribosomal RNA 5lzz 8 151 3.47 RF00002 URS00004B2C76_9986 27863242 0003735 0005840 9986 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcagguugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<<<<....>>>>.....<.<<<......>>........>>>..>...>>>....<<<..>>><<<<<<<<.......>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]]........)))..)...)))....((....))((((((((.......)))))))).................... Structure of the mammalian rescue complex with Pelota and Hbs1l (combined); 5.8S ribosomal RNA 5lzz 9 1698 3.47 RF01960,RF01959,RF00177 URS0000A7639A_9986 27863242 0003735 0005840 9986 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucguacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgcccggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcggccguccccugcucggcgccggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgaccccggucggcguaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggugcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<....<<....<<<<<.........<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<<<....>>>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<<.>>>>>>>>.>>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....<<<<<<<<<.<<<....>>>..>>>>>>.>>>......<<..<...........>..>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<....<<<.<<<..>>>.>>><<<<<<<.<<..>>>>>>.>>>.<<<<<<.<.......<<...<.......>.<<<<.>>>>...>>......>.>>>..>>>........<.<<.<<<<<<<...............>>>>>>>.>>.>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<<....>>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<.......<<........>>..........<<<<<.<....<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<..>>>>.>>>>>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.....>.>>>>>....>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>..........<.<<<<<..........>>>>>>..........>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<<<<<<<<<<<..>>>>>>>>>.>.>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..((....((((....(([...((.....((.(((.....))).))......))......)).((((...((((((....))))))...))))((..(((((...(......)..)))))......)).(]((((..((...)).))))).).)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).).....(((((((((.((......))..)))))).)))....(.((..(...........)..))......)..((((([[....(.((((.....((..]])).......))))))))))..)))))).)))..[......(.([[...(.(.((...(((..(....(((.(((())).)))).((((((.((())))))).))..((((((.(.......((..((.......)).(((.)))....))......).)))..)))........(.((.(((((((...............))))))).)).)....)....((((.(...(...((((..((..((((((((...((........))......))))))))..)).......((....))...))))..)...)..)))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.(((((....))))))))))).)..)))...((..]]))...))...].))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((..((........))..))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((...(...(((...((((((((((((..)))).))))))))...)))..).....(((((.....)))))........)))....))).))).....).))))).....).)))))...)).)))).))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..((((.((...(((((((((((((((..))))))))).).)))))...)).))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}........ Structure of the mammalian rescue complex with Pelota and Hbs1l (combined); 18S ribosomal RNA 5m1j 22 1781 3.3 RF01960,RF01959,RF00177 URS000080E2D9_4932 27995908 0003735 0005840 4932 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucau ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[........................<<.<<<.....>>>.>>................<<<<<..<<....>>..>>>>>[...((((((......<<<<<<<<<<<....>>>..............)))))).....]...<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<..<.<<<......>>>..>.>>.>>>......<<..<...........>..>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..))))))]]]].........[[[{{.......{{...[[[.[[....<<<<<<.<<<<<............>>>>>.>>>>>>.....<<<<<...............................>>>.>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[...[[..((((....>>>>>>>>.))))..]]..]].....]]....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>........<.<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>.....>.>>>>>>..>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<........................>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>....... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)).))......(((.......(((......((....(((..................((....((.(((.....))).)).....)).........(((((...(....)...)))))(.(.((((((......[[[[[[[[(((....))).....(......).)))))).)...).(.((((.(((((..).)))))))))...)))...))....))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.....))).))))).)....).).....((..(.(.....(....).....).)...))......(.(.(...........))..).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((...(.(............).)...))))))......((((....(.....................)....))).)....(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(....(.(..(((....]]]]]]]].)))..).)...).....))...(((..((.((...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)).))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((.......(........)...........(((((.(....(((((.....(..(..(((........)))..)....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..(.((..(((((.((((((....))))))...)))))..)).).))....((((((.....)))))).......)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(....((.((....((((((((.(((..(.((..(...((.(((..........................))).))...)..)).)..))).))))))))...)).)).....).))...)..)..(((((((((....)))))))))>...... Nonstop ribosomal complex bound with Dom34 and Hbs1; 18S ribosomal RNA 5m1j 14 3295 3.3 RF02540,RF02543 URS000061F377_4932 27995908 0003735 0005840 4932 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguagugagggccuuggucagacgcagcgggcgugcgugccuuguuguagacggccuugguaggucucuuguagaccgucgcuugcuacaauuaacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauagaggguguagaauaagugggagcuucggcgccagugaaauaccacuaccuuuauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>...<.....<<....>>..<<<<<......<<.....>>.....>>>>>..<<<...<.......<<.<<<<<<...>>>>>>.>>.......>.....<<<<<<.<<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>....>.............................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<......<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<......>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<......<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>....>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><<<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>.>>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<..<<........>.>.>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>...<.{.<<<<<<...<<<<.<<<<<<<<<<<<<<<<<<..[[[..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>.>.>>>>>>>.>>>>.........>>>>>>...>......>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<.<<<<..<<<<<<<.<<<..<<<<....<<<<<<<<<<<..>>>>>.>>>>>>....>>>>..>>>.<<<<<.....>>>>>....>>>>>>>.......>>>>...>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>.<.<<..<<<..<<<<<<.....<<.....<<<<....>>>>.....>>..>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>.>..>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>.....<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<..<<<<.<<.<<<<.<<<<..........<<<<.<.<<....>>............>>>>>.>>>>.>>.>>>>.>.>>>...<<<<<.....<<<<..<<<<<......>>>>>...........}...<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))......<<<<<<<..<<<<.))))))>>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>..>>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>.....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<...<<<<<<<<<<.]]]..>>>>..>>>>>>..>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<.<..<<<<.<.....>>>>>..>>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((.(((((((((((((((...(.((((......)))))[[(...).(((.....]])))....))))))))..))))))).....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.(((((......(((((((((((((((((((((((.......(((((((......((((........)))).......))))))).....))))).))))))))))........(((....)))....)))))))).....))))).)))))..((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)<)))...(((..((.((........)))).)))....))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((...(((((...((((((.....)))))).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.((.((.....)).)).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((.(((....(.........)....))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))...........(.((.....).)..)......))....))...(((((........)))))]]((((..(((((((...((((....)))...(.[.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((.(...(.(((.(..(((..((.(....(((((.(((.(()).)))..)))))....).))..))).((((.......)))).....).))).)........).)..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.....((.....((((....)))).....))..))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((......].)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(..(..(..(.....(........[..(((((..((....))..........].)))))..)......).)..)...)....((((.....((((..((((........))))...........]...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))....))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......(((((..(((..(....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)..)))..)))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(((.((..)..).)))..)))))...)))....)))).)))))).))))).. Nonstop ribosomal complex bound with Dom34 and Hbs1; 25S ribosomal RNA 5m1j 34 121 3.3 RF00001 URS000055688D_4932 27995908 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((............))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Nonstop ribosomal complex bound with Dom34 and Hbs1; 5S ribosomal RNA 5m1j 44 158 3.3 RF00002 URS00001BF64E_4932 27995908 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Nonstop ribosomal complex bound with Dom34 and Hbs1; 5.8S ribosomal RNA 5m1j X7 12 3.3 27995908 32630 gagguaaaauuc ............ ............ Nonstop ribosomal complex bound with Dom34 and Hbs1; nonstop mRNA 5m1j A3 76 3.3 RF00005 URS000011107D_4932 27995908 0030533 0006412 4932 gcggauuuancucagnngggagagcnccaganunaanaunuggagnucnugugnucgnuccacagaauucgcacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((.........)))).....(((((..]....)))))))))))).... Nonstop ribosomal complex bound with Dom34 and Hbs1; yeast Phe-tRNA-Phe 5m3h R 13 2.5 URS000080E01C_11320 28002402 11320 uauaccucugcuu ............. ............. Bat influenza A/H17N10 polymerase bound to four heptad repeats of serine 5 phosphorylated Pol II CTD; RNA (5'-R(*UP*AP*UP*AP*CP*CP*UP*CP*UP*GP*CP*UP*U)-3') 5m3h V 16 2.5 URS000080DFE6_11320 28002402 11320 aguaguaacaagaggg .<<....>>....... .((....))....... Bat influenza A/H17N10 polymerase bound to four heptad repeats of serine 5 phosphorylated Pol II CTD; RNA 5'-pAGUAGUAACAAGAGGG 5m3j R 14 3.5 URS0000B21E03_11520 28002402 11520 uauaccucugcuuc .............. .............. Influenza B polymerase bound to four heptad repeats of serine 5 phosphorylated Pol II CTD; RNA (5'-R(*UP*AP*UP*AP*CP*CP*UP*CP*UP*GP*CP*UP*UP*C)-3') 5m3j V 14 3.5 URS000080E200_11520 28002402 11520 aguaguaacaagag .<<....>>..... .((....))..... Influenza B polymerase bound to four heptad repeats of serine 5 phosphorylated Pol II CTD; RNA (5'-R(P*AP*GP*UP*AP*GP*UP*AP*AP*CP*AP*AP*GP*AP*G)-3') 5mc6 2 1767 3.8 RF01960,RF01959,RF00177 URS00005F2C2D_559292 27980209 0003735 0005840 559292 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...<<<<<.{.[[[[>>>>><<<<.<<<<<<...<.<...<..........<<<..<<....<<....<<..........>>...>>.>>......<<........<<<..<<..<<....<<<..................<<....<<.<<.......>>.>>.....>>.........<<<<<..<<....>>..>>>>><...<<<<<<......(((((((.<.<....>.>..............>>>>>>.....>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>...<<<..>>>.....>>>............<<<....<<<.....>>>..>>>..>....>.>.....<<<<<<<<<.<<......>>.>>>>>>.>>>......<<..<..<....>...>..>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>>>>>.........<<<[[.....<.<<...<<<.<<....<<<<<<.<<<<<.....<>.....>>>>>.>>>>>>.....<<<<<...............................>>>>>....<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........<<...<<<<<<<<.....))))))).>>>>>>>>..>>.....>>....<<<<<<.<<...<<<<..<<<.<<<<<<.<...<<<......>>>......>.>>>>>>.>>>.......<<....>>...>>>>..>.>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..]]>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..]]]].}<<<<<.<<<<<<<..<<.<<<<<<......<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<<<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<....................>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>...>.>>>>>>>.....>.>>>>>...>>.>>>>.........<<<<<<.......<<.....<<..<<<<....>>>>..>>....>>........>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<..........>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>.........<<<<<<<<<<..>>>>>>>>>>....... 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Cryo-EM structure of a native ribosome-Ski2-Ski3-Ski8 complex from S. cerevisiae; 18S ribosomal RNA 5mc6 l 34 3.8 27980209 559292 uuuuuuuuuuuugacaaauuuuuuuuuuuuuuuu .................................. .................................. Cryo-EM structure of a native ribosome-Ski2-Ski3-Ski8 complex from S. cerevisiae; mRNA 5mc6 m 76 3.8 RF00005 URS000042DDAB_559292 27980209 0030533 0006412 559292 gggucguuagcucaguugguagagcaguugacuuuuaaucaauuggucgcagguucgaauccugcacgacccacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((........))))..((((.......)))).......((((.......)))).))))))).... Cryo-EM structure of a native ribosome-Ski2-Ski3-Ski8 complex from S. cerevisiae; A-site tRNA 5mc6 n 77 3.8 RF00005 URS000009EE82_559292 27980209 0030533 0006412 559292 ggagcgguaguucagucgguuagaauaccugccugucacgcagggggucgcggguucgagucccguccguuccgcca <<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((.(((..((((.........)))).(((((.......)))))......((((.......)))).))).))).... Cryo-EM structure of a native ribosome-Ski2-Ski3-Ski8 complex from S. cerevisiae; P-site tRNA 5mc6 BQ 3165 3.8 RF02540,RF02543 URS000061F377_559292 27980209 0003735 0005840 559292 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Cryo-EM structure of a native ribosome-Ski2-Ski3-Ski8 complex from S. cerevisiae; 25S ribosomal RNA 5mc6 BR 121 3.8 RF00001 URS000055688D_559292 27980209 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Cryo-EM structure of a native ribosome-Ski2-Ski3-Ski8 complex from S. cerevisiae; 5S ribosomal RNA 5mc6 BS 158 3.8 RF00002 URS00001BF64E_559292 27980209 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<(.....>>............).>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Cryo-EM structure of a native ribosome-Ski2-Ski3-Ski8 complex from S. cerevisiae; 5.8S ribosomal RNA 5mdv 1 2903 2.97 RF02540,RF02541 URS0000B21DEA_562 27934701 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaacccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<.<....<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>..>>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>>.>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>.>......>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<..<<.<<<<...........<<<<<..<<.......<<<<<<<<....>>>>>>>>....>>............>>>>>..>>>>.>>..>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((.(........)).)))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((..(.........)...))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.((((..(((..((((.......))))..))).....(..(((......))))..))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((..((....))..)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((.(((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....)))).)))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((..((.(.((.(..........(((...(((.......(((((((....)))))))....))).............))).).)).).))..)))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).).....((.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..))....(.(((((....))).)).)....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((.(....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Structure of ArfA and RF2 bound to the 70S ribosome (accommodated state); 23S ribosomal RNA 5mdv 2 1534 2.97 RF00177,RF01959,RF01960 URS000081169C_562 27934701 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<......>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>..<<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>>.<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<..<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>.........>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((........))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..........)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((.((((..(((.(((....))).))).............))))..))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Structure of ArfA and RF2 bound to the 70S ribosome (accommodated state); 16S ribosomal RNA 5mdv 3 120 2.97 RF00001 URS0000049E57_562 27934701 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. .(((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))).. Structure of ArfA and RF2 bound to the 70S ribosome (accommodated state); 5S ribosomal RNA 5mdv 5 76 2.97 RF00005 URS0000B21DD1_562 27934701 0030533 0006412 562 gcggggungagcagccuggnagcucgucgggnucauaacccgaagaucgucggnucaaauccggcccccgcaaccn <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Structure of ArfA and RF2 bound to the 70S ribosome (accommodated state); fMet-NH-tRNA(fMet) 5mdw 1 2903 3.06 RF02540,RF02541 URS0000B21DEA_562 27934701 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaacccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<.<....<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>..>>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>>.>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<<.<<....>>..>>>>>>.>......>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<..<<.......<<<<<<<<....>>>>>>>>....>>............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((.(........)).)))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((..(.........)...))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(.((..(((..((((.......))))..))).....(..(((......))))..)).)...)))..))))).))...........]]].)...))))))))))...)))))))(((((..((....))..)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((.(((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....)))).)))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((((..(.(.(.((.(..........(((...(((.......(((((((....)))))))....))).............))).).)).).).)..))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(.(((((....))).)).)....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((.(....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Structure of ArfA(A18T) and RF2 bound to the 70S ribosome (pre-accommodated state); 23S ribosomal RNA 5mdw 2 1534 3.06 RF00177,RF01959,RF01960 URS000081169C_562 27934701 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<......>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>..<<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>>.<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<..<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>.........>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ........((((..[.[[[[.)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((........))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..........)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((((.......)))))))).....)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))..]]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((.((((..(((.(((....))).))).............))))..))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Structure of ArfA(A18T) and RF2 bound to the 70S ribosome (pre-accommodated state); 16S ribosomal RNA 5mdw 3 120 3.06 RF00001 URS0000049E57_562 27934701 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. .(((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))).. Structure of ArfA(A18T) and RF2 bound to the 70S ribosome (pre-accommodated state); 5S ribosomal RNA 5mdw 5 76 3.06 RF00005 URS0000B21DD1_562 27934701 0030533 0006412 562 gcggggungagcagccuggnagcucgucgggnucauaacccgaagaucgucggnucaaauccggcccccgcaaccn <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Structure of ArfA(A18T) and RF2 bound to the 70S ribosome (pre-accommodated state); fMet-NH-tRNA(fMet) 5mdy 1 2903 3.35 RF02540,RF02541 URS0000B21DEA_83333 27934701 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaacccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<.<....<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>..>>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>>.>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>.>......>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<..<<.......<<<<<<<<....>>>>>>>>....>>............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((.(........)).)))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((..(.........)...))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(.((..(((..((((.......))))..))).....(..(((......))))..)).)...)))..))))).))...........]]].)...))))))))))...)))))))(((((..((....))..)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((.(((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....)))).)))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((.(.(.((.(..........(((...(((.......(((((((....)))))))....))).............))).).)).).).)))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(.(((((....))).)).)....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((.(....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Structure of ArfA and TtRF2 bound to the 70S ribosome (pre-accommodated state); 23S ribosomal RNA 5mdy 2 1534 3.35 RF00177,RF01959,RF01960 URS000081169C_83333 27934701 0003735 0005840 83333 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<......>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>..<<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>>.<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ........((((..[.[[[[.)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((........))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..........)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((((.......)))))))).....)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))..]]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((.((((..(((.(((....))).))).............))))..))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Structure of ArfA and TtRF2 bound to the 70S ribosome (pre-accommodated state); 16S ribosomal RNA 5mdy 3 120 3.35 RF00001 URS0000049E57_83333 27934701 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Structure of ArfA and TtRF2 bound to the 70S ribosome (pre-accommodated state); 5S ribosomal RNA 5mdy 5 76 3.35 RF00005 URS0000B21DD1_562 27934701 0030533 0006412 562 gcggggungagcagccuggnagcucgucgggnucauaacccgaagaucgucggnucaaauccggcccccgcaaccn <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Structure of ArfA and TtRF2 bound to the 70S ribosome (pre-accommodated state); fMet-NH-tRNA(fMet) 5mdz 1 2903 3.1 RF02540,RF02541 URS0000B21DEA_562 27934701 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaacccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<.<....<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>..>>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>>.>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>.>......>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<..<<.......<<<<<<<<....>>>>>>>>....>>............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((.(........)).)))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((..(.........)...))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(.((..(((..((((.......))))..))).....(..(((......))))..)).)...)))..))))).))...........]]].)...))))))))))...)))))))(((((..((....))..)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((.(((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....)))).)))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.(.((.(..........(((...(((.......(((((((....)))))))....))).............))).).)).).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(.(((((....))).)).)....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((.(....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Structure of the 70S ribosome (empty A site); 23S ribosomal RNA 5mdz 2 1534 3.1 RF00177,RF01959,RF01960 URS000081169C_562 27934701 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<......>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>..<<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>>.<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ........((((..[.[[[[.)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((........))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..........)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((((.......)))))))).....)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))..]]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((.((((..(((.(((....))).))).............))))..))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Structure of the 70S ribosome (empty A site); 16S ribosomal RNA 5mdz 3 120 3.1 RF00001 URS0000049E57_562 27934701 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. .(((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))).. Structure of the 70S ribosome (empty A site); 5S ribosomal RNA 5mdz 5 76 3.1 RF00005 URS0000B21DD1_562 27934701 0030533 0006412 562 gcggggungagcagccuggnagcucgucgggnucauaacccgaagaucgucggnucaaauccggcccccgcaaccn <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Structure of the 70S ribosome (empty A site); fMet-NH-tRNA(fMet) 5me0 A 1534 13.5 RF00177,RF01959,RF01960 URS000081169C_83333 27986852 0003735 0005840 83333 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<.<<........>>.>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>.............>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((.(...((....))...)..)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..........)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(..(.((((((((.......)))))))).)...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((.....(..........).......(....)...))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..((.......))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...((((((......(((..((...(((....)))...))....)))......))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Structure of the 30S Pre-Initiation Complex 1 (30S IC-1) Stalled by GE81112; 16S ribosomal RNA 5me0 X 77 13.5 RF00005 URS00001BBAFC_83333 27986852 0030533 0006412 83333 cgcggggnggagcagccuggnagcucgucgggcucauaacccgaagaucgucggnucaaauccggcccccgcaacca ..<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>...... ...((((..((((.........)))).(((((.......))))).....(((((.......)))))))))....... Structure of the 30S Pre-Initiation Complex 1 (30S IC-1) Stalled by GE81112; fMet-tRNA 5me1 A 1534 13.5 RF00177,RF01959,RF01960 URS000081169C_83333 27986852 0003735 0005840 83333 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<.<<........>>.>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>.............>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((.(...((....))...)..)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..(......))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(..(.((((((((.......)))))))).)...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((.....(..........).......(....)...))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..((.......))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...((((((......(((..((...(((....)))...))....)))......))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Structure of the 30S Pre-Initiation Complex 2 (30S IC-2) Stalled by GE81112; 16S ribosomal RNA 5me1 X 77 13.5 RF00005 URS00001BBAFC_83333 27986852 0030533 0006412 83333 cgcggggnggagcagccuggnagcucgucgggcucauaacccgaagaucgucggnucaaauccggcccccgcaacca ..<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>...... ...((((..((((.........)))).(((((.......))))).....(((((.......)))))))))....... Structure of the 30S Pre-Initiation Complex 2 (30S IC-2) Stalled by GE81112; fMet-tRNA 5mei 1 3149 3.5 RF02540,RF02543 URS000061F377_559292 28457705 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<<.<<<<<<<<<<<<<<<<<<<<.....<<<<......>>>>.(.......<<<......)>>>....>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<.<....<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<....<....>....>>>.>>>.>>....>>>>>>.>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<......<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>....>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<<....>>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>.>>>>>..<<<<.....<<<<<<<.<<...............<<<<<...............>>>>><<.<<<<<<<<<<......>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<...<<.....<<<<....>>>>.....>>.>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<.....>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.........<<<..<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>......>>>.......<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<..<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>..>>>>>..<<<<<.....................<<<<<<<<<.<<<....<<<<....<<<<........>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((.(((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))).))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((......((((........)))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...((.(((.....))).)).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((..((....(.........)....))......(...(........).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........(..................)....))....))...(((((........)))))]]((((.((((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....))))..)))))))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((((.(...)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.........)))))))....((((.....((((..((((........))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......((((...(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).)))...))))..(((((.(..(.......)..).....(((((((((.(((....((((.(..(...((..)..)...)..)))))...)))....)))).)))))..))))).. Crystal structure of Agelastatin A bound to the 80S ribosome; 25S ribosomal RNA 5mei 3 121 3.5 RF00001 URS000055688D_559292 28457705 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of Agelastatin A bound to the 80S ribosome; 5S ribosomal RNA 5mei 4 158 3.5 RF00002 URS00001BF64E_559292 28457705 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((...(.]].)..........).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of Agelastatin A bound to the 80S ribosome; 5.8S ribosomal RNA 5mei 6 1783 3.5 RF01960,RF01959,RF00177 URS00005F2C2D_559292 28457705 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccucuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucacuggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[...............<.....<<.<<.......>>.>>......>.........<<<<<..<<....>>..>>>>>....((((((......<<<<<<<<<<<<..>>>>..............)))))).........<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<<<<..............>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.{{....<<<<<<.<<<..<<<<...>>>>......>>>.>>>>>>....<<<<<<....<<..<<<<.......>>>>..>>....>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[[..((((((((....>>>>>>>>.)))))))).]]].....}}....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<<.....>.>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<<<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>...>.>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<......<<<<<<<.<<<..<........>....>>>.>>>>>>>......>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((...............(.....((.(((.....))).))......).........(((((..((....))..)))))(.(.((((((......[[[[[[[..((....))......(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(((((((................)))).)))....(.(.(.(...........))..)......)..((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((.(((((...))))....).))).))))))....((((((....((..(((((.....)))))..))....))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(((..(.((((((.....]]]]]]].)))))).).))).....))...(((..((.((...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)).))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((.(........((.(((........))).))......).)))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...(((((((..(..................)..)))))))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>........ Crystal structure of Agelastatin A bound to the 80S ribosome; 18S ribosomal RNA 5mei AR 3149 3.5 RF02540,RF02543 URS000061F377_559292 28457705 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu .........................<<<<<.....<......>......>>>>>...........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<<.<<<<<.<<<<<<<<<<<<<<.....<<<<......>>>>.(.......<<<......)>>>....>>>>>>>>..>>>>>>.>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<<.....<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<......>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>(><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<.......>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.........>>>>.>>>>.....>>>>>.>>>>>>>>.>>).<<<<.<<<<<.....>>>>>.>>>>....<<<..[...>>>...<<<<<<<..<<<<(((.....<<<<<<......<.....]....<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>....>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<...............>>>>><<.<<<<<<<<<<......>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<..<<<.....<<<<....>>>>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<.......>>>>>>>>...<<<<<.....<<<<..<<............>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((.(.(((..((((((((...({((((......)))))[[(...).(((....}]])))....))))))))....)))..)....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((......((((........)))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...(.((((.....)))).).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.......(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........(..................)....))....))...(((((........)))))]]((((.((((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....))))..)))))))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((((.(...)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.........)))))))....((((.....((((..(((..........)))...........>...(((((......)))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.............))))...)))).))))....)))))))).......((((.(.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).).))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(.(..(..)....).)..)))))...)))....)))).)))))).))))).. Crystal structure of Agelastatin A bound to the 80S ribosome; 25S ribosomal RNA 5mei AS 121 3.5 RF00001 URS000055688D_559292 28457705 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<<............>>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of Agelastatin A bound to the 80S ribosome; 5S ribosomal RNA 5mei AT 158 3.5 RF00002 URS00001BF64E_559292 28457705 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of Agelastatin A bound to the 80S ribosome; 5.8S ribosomal RNA 5mei A 1781 3.5 RF01960,RF01959,RF00177 URS00005F2C2D_559292 28457705 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucau ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[..................<.....<<.<<.......>>.>>......>.........<<<<<..<......>..>>>>>....((((((......<<<<<<<<<<......>>..............)))))).........<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<.<<....<..........>....>>..>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.[[....<<<<<<.<<<<<....<..>....>>>>>.>>>>>>....<<<<<<...............................>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[...((((((((....>>>>>>>>.))))))))..]].....]]....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>......<<<....>>>..>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<......>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<........<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>>....>.>>>>>......>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<......<<.<<<<.<<..................>>.>>>>.>>......>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>....... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..................(.....((.(((.....))).))......).........(((((..((....))..)))))(.(.((((((......[[[[[[[[(((....))).....(......).)))))).)...).(.((((..((.......)).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(...(.(................).)....)......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((((....(())....))))).))))))....((((((...............................))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(......((.(((....]]]]]]]].))).)).....).....))...(((..((.((...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)).))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...(.((....(....................)....).))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>...... Crystal structure of Agelastatin A bound to the 80S ribosome; 18S ribosomal RNA 5mgp A 2900 3.1 RF02540,RF02541 URS0000B21DDD_562 27906161 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugucgaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccgggagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccguaaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<<..>>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<..>>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<.........>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<........>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<......>>>>...>>>>>>...>>>...>>>.>........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<<.<<....>>..>>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<...<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<..<...<<.........<<<<<......>>>>>......>>.............>..>...>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>....>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[......(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((((..)))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....(((((.((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))).))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((.((......))..))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.((.....................)).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((..........))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..((((......))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((..(((((..(((((.(((.(((((.((((((((((.....................(............(..(((......)))..)...................)............))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..).))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Structural basis for ArfA-RF2 mediated translation termination on stop-codon lacking mRNAs; 23S ribosomal RNA 5mgp B 120 3.1 RF00001 URS00008116C5_562 27906161 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Structural basis for ArfA-RF2 mediated translation termination on stop-codon lacking mRNAs; 5S ribosomal RNA 5mgp a 1539 3.1 RF00177,RF01959,RF01960 URS000080DDC0_562 27906161 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<..<....>..>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<......>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.<...>.>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<..<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>.........>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((.((.(........).))..)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..........)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((((.......)))))))).....)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....))))))).............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Structural basis for ArfA-RF2 mediated translation termination on stop-codon lacking mRNAs; 16S ribosomal RNA 5mgp x 77 3.1 RF00005 URS00001DEEBE_562 27906161 0030533 0006412 562 cggugauuggcgcagccugguagcgcacuucguucgggacgaaggggucggagguucgaauccucuaucaccgacca <<<<<<<..<<<<.........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))).... Structural basis for ArfA-RF2 mediated translation termination on stop-codon lacking mRNAs; P-site tRNA 5mlc A 2750 3.6 RF02540,RF02541 URS000026FDFF_3562 27986857 0003735 0005840 3562 uucaaacgaggaaaggcuuacgguggauaccuaggcacccagagacgaggaagggcguauuaaucgacgaaaugcuucggggaguugaaaauaagcagagauccggagauucccgaauaggucaaccuuucgaacuucugcugaauccaugggcaggcaagagacaaccuggcgaacugaaacaucuuaguagccagaggaaaagaaagcaaaagcgauucccguaguagcggcgagcgaaaugggagcagccuaaaccgugaaaacgggguugugggagaggcugcuaggcgaaucaguggagugcggaacccuagauggugaaaguccaguagccgaaagcaucacucugacccgaguagcauggggcacguggaaucccgugugaaucagcaaggaccaccuugcaaggcuaaauacuccugggugaccgauagcgaaguaguaccgugagggaagggugaaaagaacccccaucggggagugaaauagaacaugaaaccguaagcucucaagcagugggagggggaccagacccugaccgcgugccuguugaagaaugagccggcgacucauaggcaguggcuugguuaagggaacccaccggagccguagcgaaagcgagucuucauagggcaauugucacugcuuauggacccgaaccugggugaucuauccaugaccaggaugaagcuugggugaaacuaaguggagguccgaaccgacugauguugaagaaucagcggaugaguugugguuaggggugaaaugccacucgaacccagagcuagcugguucuccccgaaaugcguugaggcgcagcaguugacuggacaucuagggguaaagcacuguuucggugcgggccgcgagagcgguaccaaaucgaggcaaacucugaauacuagauaugaccuaggggucaaggucggccagugagacgaugggggauaagcuucaucgucgagagggaaacagcccggaucaccagcuaaggccccuaaaugaccgcucagugauaaaggagguaggggugcagagacagccaggagguuugccuagaagcagccacccuugaaagagugcguaauagcucacugaucgagcgcucuugcgccgaagaugaacggggcuaagcggucugccgaagcugugggauguaaaaaaacaucgguaggggagcguuccguguuagggagaaacgcgugcgugagccgcguuggacgaagcggaagcgagaaugucggcuugaguaacgcaaacauuggugagaauccaaugccccgaaaaccuaaggguuccuccgcaagguucguccacggagggugagucagggccuaagaucaggccgaaaggcguagucgauggacaacaggugaauauuccuguacuaccccuuguuggucccgagggacggaggaggcuagguuagccgaaagaugguuaucgguucaaggacgcaaggugaagggguagagaaaaugccucgagccaauguucgaguaccaggcgcuacggcgcugaaguaaccgaugccauacucccaggaaaagcucgaacgaccuucaacaaaaggguaccuguacccgaaaccgacacagguagguagguagagaauaccuaggggcgcgagacaacucucucuaaggaacucggcaaaauagccccguaacuucgggagaaggggugcccccucacaaagggggucgaagugaccaggcccgggcgacuguuuaccaaaaacacaggucuccgcaaagucguaagaccauguaugggggcugacgccugcccagugccggaaggucaaggaaguuggugaccugaugacaggggagccggcgaccgaagccccggugaacggcggccguacgguccuaagguagcgaaauuccuugucggguaaguuccgacccgcacgaaaggcguaacgaucugggcacugucucggagagaggcucggugaaauagacaugucugugaagaugcggacuaccugcaccuggacagaaagacccuaugaagcuuuacuguucccugggauuggcuuugggcuuuuccugcgcagcuuagguggaaggcgaagaaggcccccuuccgggggggcccgagccaucagugagauaccacucuggaagagcuagaauucuaaccuugugucaggaccuacgggccaagggacauucucagguagacaguuucuauggggcguaggccucccaaaagguaacggaggcgugcaaagguuuccucgggccggacggagauuggcccucgagugcaaaggcagaagggagcuugacugcaagacccacccgucgagcagggacgaaagucggccuuagugauccgacggugccgaguggaagggccgucgcucaacggauaaaaguuacucuagggauaacaggcugaucuuccccaagaguucacaucgacgggaagguuuggcaccucgaugucggcucuucgccaccuggggcuguaguauguuccaaggguugggcuguucgcccauuaaagcgguacgugagcuggguucagaacgucgugagacaguucgguccauauccggugugggcguuagagcauugagaggaccuuucccuaguacgagaggaccgggaaggacgcaccucugguguaccaguuaucgugcccacgguaaacgcuggguagccaagugcggagcggauaacugcugaaagcaucuaaguaguaagcccaccccaagaugagugcucuccuau 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..............(((((((((......((..(((((((((((.(......((((((.....[[.))).....((((((...(.(]].....).)......))))))...)))....(((....)))(..)..(.((((((.........)))))...)).)....((((((.....(...[..)......))))).).........((....))...((((......((.]...)).....))))...((((...((((....))))......(((.((((.((((.(((...((.(.......).))[[......(((.....]])))...)))...)))).).)))...))))....(((((((...[.......)))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((....))))............)......)))))))))......(.((((..((((.......))))..)))).[.(.(........).).((((((....((((.((((((((..(((...((.......))...)))...((....))..((((.....))))....)))))))).))))..((.(...((((((.....(.((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))).).(.(((....[)))...).]))))))......).))..((((((....(((((....)))))((.((((((.....((((((.....(((...(((((((.(..(..((.(....).))...)..).)))))))..)).).....))))))..((((....))))...))))))..))..((((((((((......))))))))))....(((......)))....(((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(.(((.(.....(............)....).....(...((......)).).))).)...)))..))))).))..........]]].)...))))))))))...)))))).(((((......)))))....))))))(.((((((....(......(.....((....)).....)...)...))))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((.(((((((((.((((....((((..(((..((((((((((..........)))))(...((((....(((...((((((.......))))))..)))...))))....)(..(((((....)))))...))))))...)))...))))(..).....))))...))))...)))))..))))))))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.......))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((..(..(((..((((....))))...)))..)..))...))))))))..)))))(((((())))))........((.(......).(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....))....(((((.....]..)))))..((((((((.(((..(......((((.((((((..(((((..((((.((..(...(..((((.((..........[..((..(............((...(......)...))...............]...)..))....)).))))..)...)...(((((.(((..........)))))))).....)).))))...)))))..(((......[)))((((((..........]))))))([((...((((.((.(((((((.........))))))..).((][.[[[))....)).))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.(.((((..((((((((........)))))..))).(((((.....))))).....))))...)...))).).....(((((((....))).))))....)...)))))))))))[...(((((((...(.((..(((.(((.....(....)....))).))).(((((...((((...(((((((((((....))))))...)))))...)))).)))))..(.((....((((.....}.......))))....))).)).)..]....)))))))..... Cryo-EM structure of the spinach chloroplast ribosome reveals the location of plastid-specific ribosomal proteins and extensions; 23S ribosomal RNA, chloroplastic 5mlc B 120 3.6 RF00001 URS0000538405_3562 27986857 0003735 0005840 3562 auucugguguccuaggcguagaggaaccacaccaauccaucccgaacuuggugguuaaacucuacugcggugacgauacuguaggggagguccugcggaaaaauagcucgacgccaggau <<<<<<<<<<<....<<<<<<<<.....<<.<.................>...>>....>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> ((.(((((((.....((((((((.....((.(.(...(.....)...).)...))....)))))).))((........(((((((......)))))))........))..))))))).)) Cryo-EM structure of the spinach chloroplast ribosome reveals the location of plastid-specific ribosomal proteins and extensions; 5S ribosomal RNA, chloroplastic 5mlc C 93 3.6 RF02541 URS0000525FC8_3562 27986857 0003735 0005840 3562 gaaggucacggcgagacgagccguuauaggugucaaguggaagugcagugauguaugcagcugaggcauccuaacagacccacagacuugaac ...<<<<<<<<<.......>>>>>..<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>............. ...(((((((((.......)))))..((((((((.(((....(((((....)))))...)))..))))).)))...))))............. Cryo-EM structure of the spinach chloroplast ribosome reveals the location of plastid-specific ribosomal proteins and extensions; 4.8S ribosomal RNA, chloroplastic 5mmi A 2798 3.2 RF02540,RF02541 URS000028B73E_3562 28007896 0003735 0005840 3562 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.............<<<<<<<<<<.....<<..<<<<<<<<<<<.<......<<<<<<..[..((.>>>.....<<<<<<<..<<.))..]...>>.....>>>>>>>...>>>....<<<....>>>......<<<<<<<<.........>>>>>..>>>.>....<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<....<<<<....>>>>......<<<<<<<<<....<<<<.....<.<<<<.<<<...<<.<<.....>>.>>((......<<<.....))>>>...>>>...>>>>.>....>>>>.>>>>>>..>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..>>>......>>.>>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>.................>>>>>>>>>>........<<<<..<<<<.......>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<...<<<...<<.......>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>..<<.<...<<<<<<.....<.<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>.>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<.<<<<<<<....<<<<<<......<<...<<<<<<<<<..<<<<<...>>>.>>..>>>>>>>>>..>>.......>>>>>>..<<<<<<.........>>>>>>..>>>>>>>..>>..<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<<.......<.<<<.<<<...<<.........>>...>>>.........<<......>>...>>>.>...>>>>>>>>>>.>>..........))).....>>>>>>.>>>...>>>>>>><<<<<......>>>>>....>>>>>><.<<<<<<...........<<<<<.<<....>>>>>>.>.......>>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<.<<<<.<<<<.<<<<....<<<<..<<<..<<<<<<<<<<.....(((..>>>>>....<<<<<...<<<.<<<<<<.....>>>>>>.....<<<<<<.......>>>>>>..>>>..>>>>>.....<..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>>>....>>>>..>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<..>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<..<<<<<<..<<<<....>>>>...>>>>>>..>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<..<......<<<<.<<<<<<..<<<<<..<<<<<<<..<<.<<<.<<<<<<<<<............<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>.>..>>>>>>>>>.>>>.>>...<<<<<.<<<..........>>>>>>>>.....>>>>>>>...>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<..<<<<<<<.......>>>>>>>....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..>>>>..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<.<<<<..<<<<<<<<........>>>>>..>>>.<<<<<.....>>>>>.....>>>>...>...>>>>>.....<<<<<<<....>>>.>>>>....>...>>>>>>>>>>>....<<<<<<<...<.<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>...>>>>>...>>>>.>>>>>..<.<<...<<<<<<...........>>>>>>...>>>.>>.>.......>>>>>>>.... .............(((((((((......((..(((((((((((.(......((((((..[..[[[)))...].((((((...(((]]..]..)))......))))))...)))....(((....)))......((.(((((.........)))))...)).)....((((((.....(...[..)......))))).).........((....))...((((......((.]...)).....))))...((([...(((......)))....(.(((.(((((.(..((((...(.(.((((.(((...((.((.....)).))[[(...).(((.....]])))...)))...)))).).)..))))))))))...)))]....(((((((...[.......)))))))....).(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((....))))...........)......)))))))))......(.((((..((((.......))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.......))...)))...((....))..((((.....))))....)))))))))))))..((.(...((((((.....(.((((((((.((((...(((.((......)).)))...)[)))...(((.(((((.......<))))))))..).))))))).).(.(((....[)))...).]))))))......).))..((((((....(((((....)))))((.(((((((....((((((.....(((...(((((.(....((((((.)))).))....).)))))..)).).....))))))..((((((.........))))))..)))))))..))..((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((.(.....{.(.(((.(((...((.........))...))).....(...((......)).).))).)...).)))))))).))..........]]].)...))))))))))...)))))))(((((......)))))....))))))(.((((((....(......(((((.((....)))))).)...)...))))))..).....))))))(......((.....((((((.......))))))((((....(((...((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((.(((((((((.((((....((((..(((..((((((((((.....{{{..)))))(...((((....(((.((((((.....)))))).....((((((.......))))))..)))...))))....)(..(((((....)))))...))))))...)))...))))(..).....))))...))))...)))).).))))))))).))).....((......))..))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((..))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((..(.((((..((((....))))...)))).)..))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....))....(((((.....]..)))))..((((((((.(((..(......((((.((((((..(((((..(((((((..((.(((.(((((.(((............(.((...((........(.(((......))).).....)).............)).)...))).))))).))).))...(((((.(((..........)))))))).....)))))))...)))))..(((((...)))))((((((...........))))))([((...(((((((.(((((((.........))))))..).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..)))))).......((((.(.((((((...((.......))...))))))...)))).)........((((.(.((((..((((((((........)))))..))).(((((.....))))).....))))...)...))))......(((((((....))).))))..>.)...)))))))))))[...(((((((...(.((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))...)))))...)))).)))))..(.((....((((.....}.......))))....))).)).)..]....))))))).... Structure of the large subunit of the chloroplast ribosome; 23S ribosomal RNA 5mmi B 121 3.2 RF00001 URS0000538405_3562 28007896 0003735 0005840 3562 uauucugguguccuaggcguagaggaaccacaccaauccaucccgaacuuggugguuaaacucuacugcggugacgauacuguaggggagguccugcggaaaaauagcucgacgccaggau .<<<<<<<<<<<....<<<<<<<<.....<<<<<<<............>>>>>.>>....>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> .(((((((((((....((((((((.....(((((((..(.....)...))))).))....)))))).))(((.......(((.((((....)))).))).......))).))))))))))) Structure of the large subunit of the chloroplast ribosome; 5S ribosomal RNA 5mmi W 106 3.2 RF02541 URS000000A081_3562 28007896 0003735 0005840 3562 agagaaggucacggcgagacgagccguuuaucauuacgauaggugucaaguggaagugcagugauguaugcagcugaggcauccuaacagacccacagacuugaac ......<<<<<<<<<.......>>>>>............<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>............. ......(((((((((.......)))))............((((((((.(((....(((((....)))))...)))..))))).)))...))))............. Structure of the large subunit of the chloroplast ribosome; 4.5S ribosomal RNA 5mmm A 2798 3.4 RF02540,RF02541 URS000028B73E_3562 28007896 0003735 0005840 3562 ucaaacgaggaaaggcuuacgguggauaccuaggcacccagagacgaggaagggcguauuaaucgacgaaaugcuucggggaguugaaaauaagcagagauccggagauucccgaauaggucaaccuuucgaacuucugcugaauccaugggcaggcaagagacaaccuggcgaacugaaacaucuuaguagccagaggaaaagaaagcaaaagcgauucccguaguagcggcgagcgaaaugggagcagccuaaaccgugaaaacgggguugugggagagcaauacaagcgucgugcugcuaggcgaaucaguggagugcggaacccuagauggugaaaguccaguagccgaaagcaucacuagcuuaugcucugacccgaguagcauggggcacguggaaucccgugugaaucagcaaggaccaccuugcaaggcuaaauacuccugggugaccgauagcgaaguaguaccgugagggaagggugaaaagaacccccaucggggagugaaaagaacaugaaaccguaagcucucaagcagugggagggggaccagacccugaccgcgugccuguugaagaaugagccggcgacucauaggcaguggcuugguuaagggaacccaccggagccguagcgaaagcgagucuucauagggcaauugucacugcuuauggacccgaaccugggugaucuauccaugaccaggaugaagcuugggugaaacuaaguggagguccgaaccgacugauguugaagaaucagcggaugaguugugguuaggggugaaaugccacucgaacccagagcuagcugguucuccccgaaaugcguugaggcgcagcaguugacuggacaucuagggguaaagcacuguuucggugcgggccgccgguaccaaaucgaggcaaacucugaauacuagauaugaccuccaaauaacaggggucaaggucggccagugagacgaugggggauaagcuucaucgucgagagggaaacagcccggaucaccagcuaaggccccuaaaugaccgcucagugauaaaggagguaggggugcagagacagccaggagguuugccuagaagcagccacccuugaaagagugcguaauagcucacugaucgagcgcucuugcgccgaagaugaacggggcuaagcggucugccgaagcugugggauguaaaaaaacaucgguaggggagcguuccguguuagggagaaacgcgugcgugagccgcguuggacgaagcggaagcgagaaugucggcuugaguaacgcaaacauuggugagaauccaaugccccgaaaaccuaaggguuccuccgcaagguucguccacggagggugagucagggccuaagaucaggccgaaaggcguagucgauggacaacaggugaauauuccuguacuaccccuuguuggucccgagggacggaggaggcuagguuagccgaaagaugguuaucgguucaaggacgcaaggugacccuguuuuucaggguaagaagggguagagaaaaugccucgagccaauguucgaguaccaggcgcuacggcgcugaaguaaccgaugccauacucccaggaaaagcucgaacgaccuucaacaaaaggguaccuguacccgaaaccgacacagguagguagguagagaauaccuaggggcgcgagacaacucucucuaaggaacucggcaaaauagccccguaacuucgggagaaggggugcccccucgggggucgaagugaccaggcccgggcgacuguuuaccaaaaacacaggucuccgcaaagucguaagaccauguaugggggcugacgccugcccagugccggaaggucaaggaaguuggugaccugaugacaggggagccggcgaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgacccgcacgaaaggcguaacgaucugggcacugucucggagagaggcucggugaaauagacaugucugugaagaugcggacuaccugcaccuggacagaaagacccuaugaagcuuuacuguucccugggauuggcuuugggcuuuuccugcgcagcuuagguggaaggcgaagaaggcccccuuccgggggggcccgagccaucagugagauaccacucuggaagagcuagaauucuaaccuugugucaggaccuacgggccaagggacauucucagguagacaguuucuauggggcguaggccucccaaaagguaacggaggcgugcaaagguuuccucgggccggacggagauuggcccucgagugcaaaggcagaagggagcuugacugcaagacccacccgucgagcagggacgaaagucggccuuagugauccgacggugccgaguggaagggccgucgcucaacggauaaaaguuacucuagggauaacaggcugaucuuccccaagaguucacaucgacgggaagguuuggcaccucgaugucggcucuucgccaccuggggcuguaguauguuccaaggguugggcuguucgcccauuaaagcgguacgugagcuggguucagaacgucgugagacaguucgguccauauccggugugggcguuagagcauugagaggaccuuucccuaguacgagaggaccgggaaggacgcaccucugguguaccaguuaucgugcccacgguaaacgcuggguagccaagugcggagcggauaacugcugaaagcaucuaaguaguaagcccaccccaagaugagugcucuccua .............<<<<<<<<<<.....<<..<<<<<<<<<<<.<......<<<<<<..[..((.>>>.....<<<<<<<..<<.))..]...>>.....>>>>>>>...>>>....<<<....>>>......<<<<<<<<.........>>>>>..>>>.>....<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<....<<<<....>>>>......<<<<<<<<<....<<<<....<<.<<<<.<<<...<<.<<.....>>.>>((......<<<.....))>>>...>>>...>>>>.>>...>>>>.>>>>>>..>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..>>>......>>.>>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>.................>>>>>>>>>>........<<<<..<<<<.......>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<...<<<...<<.......>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>..<<.<...<<<<<<.....<.<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>.>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<.<<<<<<<....<<<<<<.....<<<...<<<<<<<<<..<<<<<...>>>.>>..>>>>>>>>>..>>.>.....>>>>>>..<<<<<<.........>>>>>>..>>>>>>>..>>..<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<<.......<.<<<.<<....<<.........>>....>>.........<<......>>...>>>.>...>>>>>>>>>>.>>..........))).....>>>>>>.>>>...>>>>>>><<<<<......>>>>>....>>>>>><.<<<<<<...........<<<<<.<<....>>>>>>.>.......>>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<.<<<<.<<<<.<<<<....<<<<..<<<..<<<<<<<<<<.....(((..>>>>>....<<<<<...<<<.<<<<<<.....>>>>>>.....<<<<<<.......>>>>>>..>>>..>>>>>.....<..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>>>....>>>>..>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<..>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<..<<<<<<..<<<<....>>>>...>>>>>>..>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<..<......<<<<.<<<<<<..<<<<<..<<<<<<<..<<.<<<.<<<<<<<<<............<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>.>..>>>>>>>>>.>>>.>>...<<<<<.<<<..........>>>>>>>>.....>>>>>>>...>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<..<<<<<<<.......>>>>>>>....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..>>>>..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<.<<<<..<<<<<<<<........>>>>>..>>>.<<<<<.....>>>>>.....>>>>...>...>>>>>.....<<<<<<<....>>>.>>>>....>...>>>>>>>>>>>....<<<<<<<...<.<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>...>>>>>...>>>>.>>>>>..<.<<...<<<<<<...........>>>>>>...>>>.>>.>.......>>>>>>>.... .............(((((((((......((..(((((((((((.(......((((((..[..[[[)))...].((((((...(((]]..]..)))......))))))...)))....(((....)))......((.(((((.........)))))...)).)....((((((.....(...[..)......))))).).........((....))...((((......((.]...)).....))))...((([...(((......)))....(.(((.(((((.(..((((...(.(.((((.(((...((.((.....)).))[[(...).(((.....]])))...)))...)))).).)..))))))))))...)))]....(((((((...[.......)))))))....).(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((....))))...........)......)))))))))......(.((((..((((.......))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.......))...)))...((....))..((((.....))))....)))))))))))))..((.(...((((((.....(.((((((((.((((...(((.((......)).)))...)[)))...(((.(((((.......<))))))))..).))))))).).(.(((....[)))...).]))))))......).))..((((((....(((((....)))))((.(((((((....((((((.....(((...(((((((....((((((.)))).))....)))))))..)).).....))))))..((((((.........))))))..)))))))..))..((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((.(.....{.(.(((.(((...((.........))...))).....(...((......)).).))).)...).)))))))).))..........]]].)...))))))))))...)))))))(((((......)))))....))))))(.((((((....(......(((((.((....)))))).)...)...))))))..).....))))))(......((.....((((((.......))))))((((....(((...((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((.(((((((((.((((....((((..(((..((((((((((.....{{{..)))))(...((((....(((.((((((.....)))))).....((((((.......))))))..)))...))))....)(..(((((....)))))...))))))...)))...))))(..).....))))...))))...)))).).))))))))).))).....((......))..))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((..))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((..(.((((..((((....))))...)))).)..))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....].})))))..((((((((.(((..(......((((.((((((..(((((..(((((((..((.(((.(((((.((.........[...(.((...((........(.(((......))).).....))..........]..)).)....)).))))).))).))...(((((.(((..........)))))))).....)))))))...)))))..(((((...)))))((((((...........))))))([((...(((((((.(((((((.........))))))..).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..)))))).......((((.(.((((((...((.......))...))))))...)))).)........((((.(.((((..((((((((........)))))..))).(((((.....))))).....))))...)...))))......(((((((....))).))))..>.)...)))))))))))[...(((((((...(.((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))...)))))...)))).)))))..(.((....((((.....}.......))))....))).)).)..]....))))))).... Structure of the 70S chloroplast ribosome; 23S ribosomal RNA 5mmm B 121 3.4 RF00001 URS0000538405_3562 28007896 0003735 0005840 3562 uauucugguguccuaggcguagaggaaccacaccaauccaucccgaacuuggugguuaaacucuacugcggugacgauacuguaggggagguccugcggaaaaauagcucgacgccaggau .<<<<<<<<<<<....<<<<<<<<.....<<<<<<<............>>>>>.>>....>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> .(((((((((((....((((((((.....(((((((..(.....)...))))).))....)))))).))(((.......(((.((((....)))).))).......))).))))))))))) Structure of the 70S chloroplast ribosome; 5S ribosomal RNA 5mmm W 106 3.4 RF02541 URS000000A081_3562 28007896 0003735 0005840 3562 agagaaggucacggcgagacgagccguuuaucauuacgauaggugucaaguggaagugcagugauguaugcagcugaggcauccuaacagacccacagacuugaac ......<<<<<<<<<.......>>>>>............<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>............. ......(((((((((.......)))))............((((((((.(((....(((((....)))))...)))..))))).)))...))))............. Structure of the 70S chloroplast ribosome; 4.5S ribosomal RNA 5mmm z 76 3.4 RF00005 URS00005AA258_3562 28007896 0030533 0006412 3562 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).(((((.......))))).....(((((..]....)))))))))))).... Structure of the 70S chloroplast ribosome; tRNA-Phe 5mmm a 1484 3.4 RF00177,RF01959,RF01960 URS00003B54E2_3562 28007896 0003735 0005840 3562 ucucauggagaguucgauccuggcucaggaugaacgcuggcggcaugcuuaacacaugcaagucggacgggaagugguguuuccaguggcggacgggugaguaacgcguaagaaccugcccuugggaggggaacaacagcuggaaacggcugcuaauaccccguaggcugagaagcaaaaggaggaauccgcccgaggaggggcucgcgucugauuagcuaguuggugagguaauagcuuaccaaggcgaugaucaguagcugguccgagaggaugaucagccacacugggacugagacacggcccagacuccuacgggaggcagcaguggggaauuuuccgcaaugggcgaaagccugacggagcaaugccgcguggaggcagaaggcccacgggucgugaacuucuuuucccggagaagaagcaaugacgguauccggggaauaagcaucggcuaacucugugccagcagccgcgguaagacagaggaugcaagcguuauccggaaugauugggcguaaagcgucuguagguggcuuuuuaaguccgccgucaaaucccagggcucaacccuggacaggcgguggaaacuaccaagcuggaguacgguaggggcagagggaauuuccgguggagcggugaaaugcguagagaucggaaagaacaccaacggcgaaagcacucugcugggccgacacugacacugagagacgaaagcuaggggagcgaaugggauuagauaccccaguaguccuagccguaaacgauggauacuaggcgcugugcguaucgacccgugcaguguuguagcuaacgcguuaaguaucccgccuggggaguacguucgcaagaaugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaaagcgaagaaccuuaccagggcuugacaugccgcgaauccucuugaaagagaggggugccuucgggaacgcggacacagguggugcauggcugucgucagcucgugccguaagguguuggguuaagucccgcaacgagcgcaacccucguguuuaguugccaacguugaguuuggaacccugaacagacugccggugauaagccggaggaaggugaggaugacgucaagucaucaugccccuuaugcccugggcgacacacgugcuacaauggccgggacaaagggucgcgaucccgcgagggugagcuaaccccaaaaacccguccucaguucggauugcaggcugcaacucgccugcaugaagccggaaucgcuaguaaucgccggucagccauacggcggugaauucguucccgggccuuguacacaccgcccgucacacuaugggagcuggccaugcccgaagucguuaccuuaaccgcaaggagggggaugccgaaggcagggcuagugacuggagugaagucguaacaagguagccguacuggaaggugcggcuggaucac .........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<<<<.....>>>>>.>>>>>......<<.......<<<<.<<..<<<..<<<<<<<.<<<<.....<<<<<......>>>>>......>>>>....<<<....>>>....<<<....>>>.>>>>>>>.>>>.>>.>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<<..................>>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<..<.<<<<<<<<<<<.....<<<<<<.....>>>>>>...>>>>>>>>>..>>>..>>>>...<<<.<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>.>..........<<....>>.>>>>>>>..>>>>..>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<........>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<<<........>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<.<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>.>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<.<<<<....<.<<<<.<<<<..<<....>>.>>>>>>>>.>...>>>>.>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>....... .........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((.......)))).)))))......(((.......(((.((..(((..(((((((.((((.....((((((....))))))......))))....(((....)))....(((....))).))))))).))).)).))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....)))).....(((((...(.........)....))))).......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.((((..(.(((((((((((.....((((((.....))))))...)))))))))..)))..))))..((((.((((...((((((((...((((((((...((........))......))))))))...).......((....)).)))))))..))))..)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((((........)))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((((......)))))....((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...(((((.....).))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...((.((((.....(((..((...(((....)))...))....))).....)))).))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((.((((....(.((((.((((..((....)).)))))))).)...)))).)))))))..))).))))..).))...)..)..(((((((((....)))))))))}...... Structure of the 70S chloroplast ribosome; 16S ribosomal RNA 5mps I 34 3.85 URS0000B21DEE_4932 28076345,26292705,26106855,26829225,27459055 4932 guaugucuaaaguuaugcucuuauuuacuaacaa .................................. .................................. Structure of a spliceosome remodeled for exon ligation; Yeast UBC4 gene for ubiquitin-conjugating enzyme 5mps E 16 3.85 URS0000B21E0A_4932 28076345,26292705,26106855,26829225,27459055 4932 uaagugaucuagaaag ................ ................ Structure of a spliceosome remodeled for exon ligation; UBC4 gene exon 5mps 2 49 3.85 RF00004 URS000023C730_4932 28076345,26292705,26106855,26829225,27459055 0045131 0000348 0005686 4932 acgaaucucuuugccuuuuggcuuagaucaaguguaguaucuguucuuu ................................................. ................................................. Structure of a spliceosome remodeled for exon ligation; U2 snRNA 5mps 6 99 3.85 RF00026 URS00006184A9_4932 28076345,26292705,26106855,26829225,27459055 0030621 0000244,0000353 0005688,0046540 4932 guucgcgaagcuucguggacauuuggucaauuugaaacaauacagagaugaucagcaguuccccugcauaaggaugaaccguuuuacaaagagauuuau <<<<<<<<<..>>>>>>>>>.....................................<<<..<<<.....>>>...>>>.................... (((((((((()))))))))).....................................(((.((((.....)))..)))).................... Structure of a spliceosome remodeled for exon ligation; Saccharomyces cerevisiae strain T.52_2H chromosome XII sequence 5mps 5 141 3.85 RF00020 URS0000514318_4932 28076345,26292705,26106855,26829225,27459055 0000244,0000353 0005682,0046540 4932 cagcuuuacagaucaauggcggagggaggucaacaucaagaacugugggcgccuauagaacuuauaacgaacaugguucuugccuuuuaccagaaccauccggguguugucuccauagaaacagguaaagcuguauuuuuu <<<<<<<<<.......<.......<<<<<.<<<<<<<.....<<<<<<<..>>>>>>>..............<<<<<<<<...........>>>>>>>>...>>>>>>>>>>>>......>...>>>>>>>>>........ (((((((((.......(.......(((((.(((((((.....(((((((()))))))).........((...((((((((.(.......).)))))))).))))))))))))))......)...)))))))))........ Structure of a spliceosome remodeled for exon ligation; U5 snRNA 5mq0 I 34 4.17 URS0000B21DEE_4932 28076345,26292705,26106855,26829225,27459055 4932 guaugucuaaaguuaugcucuuauuuacuaacaa .................................. .................................. Structure of a spliceosome remodeled for exon ligation; Yeast UBC4 gene for ubiquitin-conjugating enzyme 5mq0 E 16 4.17 URS0000B21E0A_4932 28076345,26292705,26106855,26829225,27459055 4932 uaagugaucuagaaag ................ ................ Structure of a spliceosome remodeled for exon ligation; 5'-EXON OF UBC4 PRE-MRNA 5mq0 2 155 4.17 RF00004 URS000023C730_4932 28076345,26292705,26106855,26829225,27459055 0045131 0000348 0005686 4932 acgaaucucuuugccuuuuggcuuagaucaaguguaguaucuguucuuuguaacaacugaaaugaccuaggcucauuguuacggacgggaagaggagacgucgcgacccucgcagucguucuugacuggucgcuugauguuucuucuucccguuc .................................................<<<<<<<......<<<<<<>>>.>>>>>>>>>><<<<<<<<<<<.<<<<<<<<<<<<.<<.....<<<<....>>>>.>>>>>>..>>>>>>>>.>>>>>>>>>>> .................................................(((((((......(((((())).))))))))))(((((((((((.((((((((((((.((.....((((....)))).))))))..)))))))).))))))))))) Structure of a spliceosome remodeled for exon ligation; S.cerevisiae chromosome II reading frame ORF YBR230c 5mq0 6 99 4.17 RF00026 URS00006184A9_4932 28076345,26292705,26106855,26829225,27459055 0030621 0000244,0000353 0005688,0046540 4932 guucgcgaagcuucguggacauuuggucaauuugaaacaauacagagaugaucagcaguuccccugcauaaggaugaaccguuuuacaaagagauuuau <<<<<<<<<..>>>>>>>>>.....................................<<<..<<<.....>>>...>>>.................... (((((((((()))))))))).....................................(((.((((.....)))..)))).................... Structure of a spliceosome remodeled for exon ligation; Saccharomyces cerevisiae strain T.52_2H chromosome XII sequence 5mq0 5 141 4.17 RF00020 URS0000514318_4932 28076345,26292705,26106855,26829225,27459055 0000244,0000353 0005682,0046540 4932 cagcuuuacagaucaauggcggagggaggucaacaucaagaacugugggcgccuauagaacuuauaacgaacaugguucuugccuuuuaccagaaccauccggguguugucuccauagaaacagguaaagcuguauuuuuu <<<<<<<<<.......<.......<<<<<.<<<<<<<.....<<<<<<<..>>>>>>>..............<<<<<<<<...........>>>>>>>>...>>>>>>>>>>>>......>...>>>>>>>>>........ (((((((((.......(.......(((((.(((((((.....(((((((()))))))).........((...((((((((.(.......).)))))))).))))))))))))))......)...)))))))))........ Structure of a spliceosome remodeled for exon ligation; Saccharomyces cerevisiae strain WI_C_MBSP_4 chromosome VII sequence 5mqf Y 32 5.9 28076346 9606 guaagagccuccuugaugaugucauacuuaug ................................ ................................ Cryo-EM structure of a human spliceosome activated for step 2 of splicing (C* complex); MINX pre-mRNA (intron) 5mqf Z 12 5.9 28076346 9606 ggccuccgaacg ............ ............ Cryo-EM structure of a human spliceosome activated for step 2 of splicing (C* complex); MINX pre-mRNA (intron) 5mqf 2 140 5.9 RF00004 URS00003EE995_9606 28076346 0045131 0000348 0005686 9606 cgcuucucggccuuuuggcuaagaucaaguguaguaucuguucuuaucaguuuaauauauauuaaauggauuuuuggagcagggagauggaguccacuccacgcaucgaccugguauugcaguaccuccaggaacggugc ...................................................<<<<<<..>>>>>>.................<<<<.<<<<.>>>>>>>>..<<<<<<.<<<<<.............>>>>>..>>>>>> ...................................................((((((())))))).................((((.((((.))))))))..(((.((.(((((.............)))))..)).))) Cryo-EM structure of a human spliceosome activated for step 2 of splicing (C* complex); Human gene for small nuclear RNA U2 (snRNA U2) 5mqf 5 114 5.9 RF00020 URS0000118C49_9606 28076346 0000244,0000353 0005682,0046540 9606 acucugguuucucuucagaucgcauaaaucuuucgccuuuuacuaaagauuuccguggagaggaacaacucugagucuuaacccaauuuuuugagccuugccuuggcaaggcua .<<<...<<<<<<<<<<........<<<<<<<<...........>>>>>>>>...>>>>>>>>>>.......>>>..................<<<<<<<<....>>>>>>>>. .(((...((.((((.((........((((((((...........))))))))...)).)))).)).......)))..................((((((((....)))))))). Cryo-EM structure of a human spliceosome activated for step 2 of splicing (C* complex); Homo sapiens U5 A small nuclear RNA 5mqf 6 89 5.9 RF00026 URS000035C796_9606 28076346 0030621 0000244,0000353 0005688,0046540 9606 gugcucgcuucggcagcacauauacuaaacgauacagagaagauuagcauggccccugcgcaaggaugacacgcaaauucgugaagcgu <<<<<.<<....>>>>>>>..............................<<...<<<.....>>>....>>.................. (((((.((....)))))))..............................((..((((.....)))..).)).................. Cryo-EM structure of a human spliceosome activated for step 2 of splicing (C* complex); Homo sapiens RNA, U6 small nuclear 1 (RNU6-1), small nuclear RNA 5mrc A 2709 3.25 RF02541,RF02540,RF02540,RF02540 URS0000B21DE8_4932 28154081 0003735 0005840 4932 guagaauaauagauuugaaauauuuauuauauagauuuaaagagauaaucauggaguauaauaauuaaauuuaauuuaauauaacuauuaauagaagguuacuaauaaauuaauaauuaauuuuaaaaccuaaagguaaaccuuuauauuaauaauguuaugaauaauuauuaauaauaauaaacuaagugaacugaaacaucuaaguaacuuaaggauaagaaaucaacagagauauuaugaguauuggugagagaaaauaauaaaggucuaauaaguauuaugugaaaaaaauguaagaaaauaggauaacaaauucuaagacuaaauacuauuaauaaguauaguaaguaccguaagggaaaguaugaaaaugauuauuuuauaagcaaucaugaauauauuauauuauauuaaugauguaccuuuuguauaaugggucagcaaguaauuaauauuaguaaaacaauaaguuauaaauaaauagaauaauauauauauauaaaaaaauauauauuuaauuaauauuaauugacccgaaagcaaacgaucuaacuaugauaagauggauaaacgaucgaacagguugauguugcaauaucaucugauuaauugugguuaguagugaaagacaaaucugguuugcagauagcugguuuucuaugaaauauauguaaguauagccuuuauaaauaauaauuauuauauaauauauuauauaaagaaugguacagcaauuaauauauauuagggaacuaguuuuuuaauaauauuaaaucucgaaauauuuaauuauauauaauaaagagucagauuaugugcgauaagguaaauaaucuaaagggaaacagcccagauuaagauauaaaguuccuaauaaauaauaagugaaauaaauauuaaaauaaauauuuaaaaucaaauauauauauauuuguuaauagauaauauacggaucuuaauaauaagaauuauuuaauuccuuggaauauuauauuuuaaaauauaaauacugaauaucuaaauauuauuauuauaauaauaauaauaugguaauagaacauuuaaugauaauauauauuaguuauuaauuaauauauguauuaauuaaauagagaaugcugacaugaguaacgaaaaaaagguauaaaccuuuucaccuaaaacauaagguuuaacuauaaaaguacggccccuaauuaaauuaaauauaaauauauuuaagaugggauaaucuauauuaauauuuaucuuaaaauauauaauuauauuauauauuauauauuuauauaauauaaacuaauaaagaucaggaaaauuaauguauaccguaauguagaccgacucagguauguaaguagagaauaugaaggugaauuagauaauuaaagggaaggaacucggcaaagauagcucauaaguuagucaauaaagaguaauaagaacaaaguuguacaacuguuuacuaaaaacaccgcacuuugcagaaacgauaaguuuaaguauaaggugugaacucugcuccaugcuuaauauauaaauaaaauuauuuaacgauaauuuaauuaaauuuagguaaauagcagccuuauuaugaggguuauaauguagcgaaauuccuuggccuauaauugaggucccgcaugaaugacguaaugauacaacaacugucuccccuuuaagcuaagugaaauugaaaucguagugaagaugcuauguaccuucagcaagacggaaagacccuaugcagcuuuacuguaauuagauagaucgaauuauuguuuauuauauauaaugauaauucuaaucuuauacuuaauucuuaaguaauauauaauauauauauauauuauauauuauaagagacaaucucuaauugguaguuuugauggucauuaucagcaaaaguaucugaauaaguccauaaauaaauauauaaaauuauugaaaaaaauaauauauauuauauauauuaauuauaaauugaaauauguuuaauugaauauauuuuaguaauagauaaaaauauguacaguaaaauuguaaggaaaacaauaauaacuuucucggaaagaauuaaauuaauauaaugguauaacugugcgauaauuguaacacaaacgagugaaacaaguacguaaguauggcauaaugaacaaauaacacugauuguaaagguuauugauaacgaauaaaaguuacgcuagggaaggguaauauagcgaaagaguagauauuguaagcuauguuugccaccuucgacucaacauuuccucuugguuguaaaagcuaagaaggguuugacuguucgucaauuaaaauguuacgugaguuggguuaaauacgaugugaaucaguaugguuccuaucugcugaaggaaauauuaucaaauuaaaucucauuauuaguacgcaaggaccauaaugaaucaacccaugguguaucuauugauaauaauauaauauauuuauuaauauauuaucuauauuaguuuauauuuuaauuauuaucauaguagauaagcuaaguugauaauaaauaaauauugaauacauauuaaauaugaaguuguuuuaauaagauaauuaaucugauaauuuuauacuaaaauuaauaauuauagguuuuauauauuauuuauaauuauaauauuaauaaaauacuaauuuaucaguuaucuauauaauaucuaaucuauuauucuauau <<<<<<<<<<<<<<<.<<......<<<<<<<<<<<<.....<<<<<<<<<<<...<<<<....<<<<<<<<.>>>>>>>>...<<<<<<<<<<..<<<<.......<<<<<<<...>>>>>>>....>>>>..<<<....>>>....<<<<<<<<<..<....>..>>>>>>>>>.........<<<<<<.....<<....>>......>>>>>.>..<<.....<<....>>..<<<<<<.....<<.....>>....>>>>>>...<<<.........<<<<<<.......>>>>>>......<<<<..((((.>>>>..>>>....>>.>>>>>>>>.>>..........<<....>>....>>>>....>>>>>>>>>>>.......<<<<<.<<<<<<......>>>>>>.>>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<.....>>>....................<<<<.<......>.>>>>.......>>>>>>>>>>>>>..<<.<..<<<<<<<....<<<<<<<<<<..<<<<......>.>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>>...<<.....>>.......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<..<..<<<<<<<<<<<<<<<<..>>>>>>>>>..<<<<...<<<...<<<<<<<.<<<<<<<<<<<<>>>>>>>>>>>>>>>>>>>..>>.>...>>>>>>>>>>>...>.>>>>>>.>>..<<<<<<.<<<......>>>.>>>>>>....<<<......>>>...<<<.<<<<...<<<(((...<<<<<<<.....<<......<<<<<<<<<<..>>>>>.....<<<<<<<<..>>>>>>>>.>>>>>..........)))>>.............>>>>>>><<<<<..>>>>>.<<<<<<<<..>>>>>>>>..>>>...>>>>>>><<<<<<<<<<<<...>>>>>>>>>>>>....>>>>>>..<<<<<<......<<<<<<<<<<<...>>>>>>>>>>>......>>>>>>........>>>>>><......<<....<<<<<<......>>>>>><<<<<...<<<<<.<.............((..<<<.<<<...<<<...<..<<<<..>>>>>..>>>...>>>.....)).<<<<<<<.<<<.....<<.<<<......>>>.>>.<<<<<<<<<<<..>>>>>>>>>.[[..>>....>>>........>>>>>>>....>>>...>.....<<......>>>>>>>..<<<.....>>>..>>>>>..<<<<....<<<<<<<<.<<.................<<<....<.....>......>>>.............<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>..<<<<.<<<..<<<<<<<<.<<.....<.<<<<<<<<....>>>>>>>>>.....>>>>>>>>..>>>>><<<<<........>>>>>........<...........<<<<<.......>>>>>.....>....>>.>>..>>.>>>>>>......>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.<<<....<<<<<.<<<<<<..<<<<.<<<<<<<..<<<.<<<<<<<<<<<.<<.....>>>>>>>>>>>>>...<<<<<<<<<.<....>.>.>>.<<<<<<<<<<<<<..>>>>>>>>>>>>>.>>>>>>....>>>>>>>>>>..>>>>..<<<<.>>>><<<<<<...........>>>.>>>..<<....<<<.....<<<....>>>..........<<<<<<<.....>>>>>>>...>>>.....<<<<<<<<<<<....>>>>>>>>>>>.................<<<<<<<....<<<<<.......>>>>><<<..<<<<<<.>>>>>>.>>>......<<.[.(((>>....>>>>>>>....<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))].......<<<<<<.<<..))))..>>>>>>>>.............>>>>..>>>>>>>..<<<<.<.<<<<<....<<.......>>....>>>>>...>>>>.>..<<<<<..<<<<<..<<<<<<<<<.......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>......>>>.>>....<<<<<<<....>>>.>>>>...>>>..>>>>>>>>>>>.....<<<<<..<<<<<<..<<<<<<<...............>>>>>>><<<<<<....<<<..<<<<<<<<<<<<<<<.<<<<<<<<<<....>>>>>>>>>>..<<<<...]].>>>>.....>>>>>>>>>..>>>>>>..>>>..>>>>>>..<<<.<..<<<<<............>>>>>...>>>>.>>>>>>..>>>>>.....<<<<<<<<<<.......>>>>>........<<<<<<<<<<..<<...<<<<<..>>>>>.>>..>>>>>>>.>>>....>>>>>..>>>>>>>>>>>>>>.>>>>>>>>>>>>>>>.. (((((((((((((((.((......((((((((((((.....((((((((((....((((....((((((((.))))))))...(((((((((((.((((.......((((((((.))))))))....))))..(((....)))....(.(((((((..(....)..))))))).).........((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))....(((.........((((((.......))))))......((((..[[[[.))))..)))......))))))))).))..........((....))....)))).....)))))))))).....(.((((..((((((......))))))..)))).[.(.(........).).((((((..(.(((((((((((((..(((.....)))....................((((.(......).)))).......)))))))))))))..((.(...((((((.....((((((((((.((((......)[)))...(((..((((........)))).)))..).))))))))).(..((.....))....)..))))))......).))).((((((....(((((....)))))((((((((.....((((((((((((((((())))))))))...((....(((...(((((((.(((((((((.(())).)))))))))))))))..)).)....)).))))))).....)))))).))..((((((.(((......))).))))))....(((......)))...(((..(((...((([[[...(((((((.....((......((((((((((..))))).....((((((((..)))))))).)))))..........]]])).............)))))))(((((..))))).((((((((()))))))))..)))...))).)))((((((((((((...))))))))))))....))))))(.((((((......(((((((((((...)))))))))))......))))))..).....))))))(......((....((((((......))))))((((....((((..(..(.......)..[[...((.(((.(.(((.(.(..(((....)))).))))..)))).....]](.((((((.(((.(...((.(((..()..))).)).(((((((((((..))))))))).{{..))..).)))........))))))...).))....).....((......)).))))..((.......))...))))..((((....((((((((.((..(....(........((((....(.{...)......))).........)...((((((((.].((.........))...(((((((.....(((.....))).......))))))).}..((.(((..((((((((.(......(.((((((((....)))))))))......)))))))..)))))(((((........)))))........((..........(((((.......)))))..)..)....)).....)).))))))..)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.(((...((((((.((((((..(((((.((((((..(((.(((((((((((..(.....).)))))))))))...((((((..(.(....).)....(((((((((((((()))))))))))))).))))))....)))))))))..)))))..((((.))))((((((...........))).)))([((....((......(((....)))..........(((((((.....)))))))....)).....(((((((((((....)))))))))))...............(..((((((.(..(((((.......)))))(((..((((((.)))))).)))....).((][.[[[))....)))))).)...((((..(((...{..)))..)))).(((....))).))]]].]......((((((.((..]]]]..)))))))).....)}......))))..)))))))..((((.(.(((((....((.......))....)))))...)))).).)(((((.((((((..(((((((((.......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))...)))..))))))))))).....(((((...(((((..(((((((.....(....)....)))))))((((((...((((...((((((((((((((.((((((((((....))))))))))..((((...}}.)))).....)))))))))..)))))...)))).))))))...((....((((..............))))....))..)))))...)))))..(..((((((((((.......)))))........((((((((.(..((...(((((..))))).))..).))))).)))....)))))).)))))))))))))).))))))))))))))).. Structure of the yeast mitochondrial ribosome - Class A; 21S ribosomal RNA 5mrc aa 1501 3.25 RF00177,RF01959,RF01960 URS000060F99B_4932 28154081 0003735 0005840 4932 uaagaauaugauguugguucagauuaagcgcuaaauaaggacaugacacaugcgaaucauacguuuauuauugagauaauaaauaugugguguaaacgugaguaauuuuauuaggaauuaaugaacuauagaauaagcuaaauacuuaauauuauauaaaaaauuuauauaauaaaaaggauauauauauauauauuuaucuauagucaagccaauaaugguuuagguaguagguuuauuaagaguuaaaccuagccaacgauccauaaucgauaaugaaaguuagaacgaucacguugacucugaaauauagucaauaucuauaagauacagcagugaggaauauuggacaaugaucgaaagauugauccaguuacuuauuaggaugauauauauauauauauaaauugauuaaaaauaaaauccauaaauaauuaaaauaaugauauuaauuaccauauauuuauauggauauauauauauuuuaauaguccugacuaauauuugugccagcagucgcgguaacacaaagagggcgagcguuaaucauaaugguuuaaaggauccguagaaugaauuauauauaauuuagaguuaauaaaauuaauuaaagaauuauaauaguaaagaugaaauaauaauaauaauuauaagacuaauauaugugaaaauauuaauuaaauauuaacugacauugagggauuaaaacuagaguagcgaaacggauucgauacccguguaguucuaguaguaaacuaugaauacaauuauuuauaauauauauauaaauaauaaaugaaaaugaaaguauuccaccugaagaguacguuagcaauaaugaaacucaaaacaauagacgguuacagacuuaagcaguggagcauguuauuuaauucgauaauccacgacuaaccuuaccauauuuugaauauuauaauaauuauaauuauuauauuacaggcguuacauuguugucuuuaguucgugcugcaaaguuuuagauuaaguucauaaacgaacaaaacuccauauauauaauuuuaauuauauauaauuuuauauuauuuaauauaaagaaaggaauuaagacaaaucauaaugauccuuauaauauggguaauagacgugcuauaauaaaaugauaauaaaauuauauaaaauauauuuaauuauauuuaauuaauaauauaaaacauuuuaauuuuuaauauauuuuuuuauuauaaauaugaauuauaaucugaaauucgauuauaugaaaaaagaauugcuaguaauacguaaauuaguauguuacggugaauauucuaacuguuucgcacuaaucacucaucacgcguugaaacauauuauuaucuuauuauuuauauaauauuuuuuaauaaauauuauuaauuuauauuuauuuauaucagaaauaauaugaauuaaugcgaaguugaaauacaguuaccguaggggaaccugcggugggcuuauaaauaucuuaaauauucuuaca ...<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<......<<<.<<<..<<<..<<<<<<<<<<<<..>>>>>>>>>>..>>>>>.....<<<........<<<<<.<<.........<<<<<<<<.<<<<.......>>>>...<<<<<<<<<...>>>>>>>>>......<<<<<<<<<..>>>>>>>>>.>>>>>>>>....>>>>>>><<<....<<<..<<<<<<<<........>>>>>>>>>>>......>>>..<<<<.<<<<....>>>>...>>>>.>>><<<<<<.........>>>>>><<<<.....>>>>..>>>>>>.........<<<....<<<<....>>>>..>>>...>.>>>>>>.<<<<..<<<<<<....>>>>>>..<<......>>.....>>>>..<<<<<<<<..............>>>>><<<<<<<..>>>>>>><<<<<..>>>>>>>>....<<<<<(((.....<<<<.....<<.)))>>.......>>>>.>>>>>..>>>>>>>>>.....<<<((.....<<<<...<.<<.<<<<<<..>>>>>>...<<<<<<<<...<<<<<<<<<<..<<<<<<<........................>>>>>>>..>>.......<<....>>.>>>>>>>>.>>>>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<.<..>..>>>>>>>>>>..<<..))>>....>>>>>>.>>>.<<.......<<<<....>>>>.....>>..)))).]<<.<<...<<<<.....<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<.....<<.<<<<<<<<<<..>>>>>>>>>>.>>.<<<.<<<..<<<<<<<<<....<<<<<<<<<....>>>....<<......>>....>>>>>>.....<<<.<<<<<<<<........>>>>>>>>..<<<<<<<<<..>>>>>>>>>....>>>.....>>>.>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<........<<<..<<..<<<<<<......>>>>>>..>>....>>>......>>>>>>......<<<<<........>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<.<<<<<.........>>>>>>>...........>>>>..>>..>>....<.<<<.<.<<<<<<<<..<<<<<<<<<.<<<...<<<..<<<.<<<<<...<<<<<<<...>>>>>>>...>>>>>>>>..>>>..>>>>>>>>>>>>..>>>>>>>>..>.>>>..>.....<<<<<<<<<....>>>>>>>>>............................. ...((((..[.[[[[.)))).((((.(((((..(((((((((....(((.(((..(((..(((((((((((....)))))))))..))))).....((((.......(((((.((...(...(.((((((((.((((.......))))...(((((((((...)))))))))......((((((.((())).)))))).))))))))).).)))))))(((....(((..((((((((........)))))))))))......)))..((((.((((....))))...))))))))((((((.........))))))(((((..).))))..)))))).).....(.(((...(((((....)))).))))).)).)))))).((((..((((((....))))))..((......)).....))))....(((((...(.......)....))))(((((((..)))))))(..(....)..))......((((([[[.....((((.....((.]]])).......)))).)))))..)))))))))...(.((([[...(.((((...(.((.((((((..))))))..(((((((((...((((((((((..(((((((....(...........).......)))))))..)).......((....)).)))))))).))))))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((.(((((((((((.().).))))))))))..((..]]))....)))))))))))((.......((((....)))).....))..]]]].]((.((...((((......(((((..((((((((((......((........))........(.(((((((..(..((.((((((((((())))))))))).))).((.(((..(((((((((....(((((((((....)))....((......))....)))))).....(((.((((((((........))))))))..(((((((((..)))))))))....))).....))).)))...))))))))....))))))))..)).)))))))).(...(((.((........(((..((...(((((......)))))...))....)))......)).)))......(((((.(....).)))))......(....(((((((........)))))))....)..)..))))).....((.(((((.........)))))))...........))))..))..))..(.(..((.(.((((((((..(((((((((.((....(((..(((.(((((...(((((((.())))))))...))))))))..)))...)))))))))))..))))))))..).))...)..)..(((((((((....)))))))))}............................ Structure of the yeast mitochondrial ribosome - Class A; 15S ribosomal RNA 5mrc bb 76 3.25 RF00005 URS0000B21DDE_4932 28154081 0030533 0006412 4932 ggcuacguagcucaguugguagagcacaucacucauaaugauggggucacagguucgaaucccgucguagccacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>......<.<<.......>>.>.>>>>>>>.... ((((((...(((..........))).(((((.......)))))......(.((.......)).)..)))))).... Structure of the yeast mitochondrial ribosome - Class A; tRNA 5mre A 2709 3.75 RF02541,RF02540,RF02540,RF02540 URS0000B21DE8_4932 28154081 0003735 0005840 4932 guagaauaauagauuugaaauauuuauuauauagauuuaaagagauaaucauggaguauaauaauuaaauuuaauuuaauauaacuauuaauagaagguuacuaauaaauuaauaauuaauuuuaaaaccuaaagguaaaccuuuauauuaauaauguuaugaauaauuauuaauaauaauaaacuaagugaacugaaacaucuaaguaacuuaaggauaagaaaucaacagagauauuaugaguauuggugagagaaaauaauaaaggucuaauaaguauuaugugaaaaaaauguaagaaaauaggauaacaaauucuaagacuaaauacuauuaauaaguauaguaaguaccguaagggaaaguaugaaaaugauuauuuuauaagcaaucaugaauauauuauauuauauuaaugauguaccuuuuguauaaugggucagcaaguaauuaauauuaguaaaacaauaaguuauaaauaaauagaauaauauauauauauaaaaaaauauauauuuaauuaauauuaauugacccgaaagcaaacgaucuaacuaugauaagauggauaaacgaucgaacagguugauguugcaauaucaucugauuaauugugguuaguagugaaagacaaaucugguuugcagauagcugguuuucuaugaaauauauguaaguauagccuuuauaaauaauaauuauuauauaauauauuauauaaagaaugguacagcaauuaauauauauuagggaacuaguuuuuuaauaauauuaaaucucgaaauauuuaauuauauauaauaaagagucagauuaugugcgauaagguaaauaaucuaaagggaaacagcccagauuaagauauaaaguuccuaauaaauaauaagugaaauaaauauuaaaauaaauauuuaaaaucaaauauauauauauuuguuaauagauaauauacggaucuuaauaauaagaauuauuuaauuccuuggaauauuauauuuuaaaauauaaauacugaauaucuaaauauuauuauuauaauaauaauaauaugguaauagaacauuuaaugauaauauauauuaguuauuaauuaauauauguauuaauuaaauagagaaugcugacaugaguaacgaaaaaaagguauaaaccuuuucaccuaaaacauaagguuuaacuauaaaaguacggccccuaauuaaauuaaauauaaauauauuuaagaugggauaaucuauauuaauauuuaucuuaaaauauauaauuauauuauauauuauauauuuauauaauauaaacuaauaaagaucaggaaaauuaauguauaccguaauguagaccgacucagguauguaaguagagaauaugaaggugaauuagauaauuaaagggaaggaacucggcaaagauagcucauaaguuagucaauaaagaguaauaagaacaaaguuguacaacuguuuacuaaaaacaccgcacuuugcagaaacgauaaguuuaaguauaaggugugaacucugcuccaugcuuaauauauaaauaaaauuauuuaacgauaauuuaauuaaauuuagguaaauagcagccuuauuaugaggguuauaauguagcgaaauuccuuggccuauaauugaggucccgcaugaaugacguaaugauacaacaacugucuccccuuuaagcuaagugaaauugaaaucguagugaagaugcuauguaccuucagcaagacggaaagacccuaugcagcuuuacuguaauuagauagaucgaauuauuguuuauuauauauaaugauaauucuaaucuuauacuuaauucuuaaguaauauauaauauauauauauauuauauauuauaagagacaaucucuaauugguaguuuugauggucauuaucagcaaaaguaucugaauaaguccauaaauaaauauauaaaauuauugaaaaaaauaauauauauuauauauauuaauuauaaauugaaauauguuuaauugaauauauuuuaguaauagauaaaaauauguacaguaaaauuguaaggaaaacaauaauaacuuucucggaaagaauuaaauuaauauaaugguauaacugugcgauaauuguaacacaaacgagugaaacaaguacguaaguauggcauaaugaacaaauaacacugauuguaaagguuauugauaacgaauaaaaguuacgcuagggaaggguaauauagcgaaagaguagauauuguaagcuauguuugccaccuucgacucaacauuuccucuugguuguaaaagcuaagaaggguuugacuguucgucaauuaaaauguuacgugaguuggguuaaauacgaugugaaucaguaugguuccuaucugcugaaggaaauauuaucaaauuaaaucucauuauuaguacgcaaggaccauaaugaaucaacccaugguguaucuauugauaauaauauaauauauuuauuaauauauuaucuauauuaguuuauauuuuaauuauuaucauaguagauaagcuaaguugauaauaaauaaauauugaauacauauuaaauaugaaguuguuuuaauaagauaauuaaucugauaauuuuauacuaaaauuaauaauuauagguuuuauauauuauuuauaauuauaauauuaauaaaauacuaauuuaucaguuaucuauauaauaucuaaucuauuauucuauau 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(((((((((((((((.((......((((((((((((.....((((((((((....((((....((((((((.))))))))...(((((((((((.((((.......(((((.((.)).)))))....))))..(((....)))....(.(((((((..(....)..))))))).).........((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))....(((.........((((((.......))))))......((((..[[[[.))))..)))......))))))))).))..........((....))....)))).....)))))))))).....(.((((..((((((......))))))..)))).[.(.(........).).((((((..(.(((((((((((((..(((.....)))....................((((.(......).)))).......)))))))))))))..((.(...((((((.....((((((((((.((((......)[)))...(((..((((........)))).)))..).))))))))).(..((.....))....)..))))))......).))).((((((....(((((....)))))((((((((.....((((((((((((((((())))))))))...((....(((...(((((((.(((((((((.(())).)))))))))))))))..)).)....)).))))))).....)))))).))..((((((.(((......))).))))))....(((......)))...(((..(((...((([[[...(((((((.....((......((((((((((..))))).....((((((((..)))))))).)))))..........]]])).............)))))))(((((..))))).((((((((()))))))))..)))...))).)))((((((((((((...))))))))))))....))))))(.((((((......(((((((((((...)))))))))))......))))))..).....))))))(......((....((((((......))))))((((....((((..(..(.......)..[[...((.(((.(.(((.(.(..(((....)))).))))..)))).....]](.((((((.(((.(...((.(((..()..))).)).(((((((((((..))))))))).{{..))..).)))........))))))...).))....).....((......)).))))..((.......))...))))..((((....((((((((.((..(....(........((((....(.{...)......))).........)...((((((((.].((.........))...(((((((.....(((.....))).......))))))).}..((.(((..((((((((.(......(.((((((((....)))))))))......)))))))..)))))(((((........)))))........((..........(((((.......)))))..)..)....)).....)).))))))..)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.(((...((((((.((((((..(((((.((((((..(((.(((((((((((..(.....).)))))))))))...((((((..(.(....).)....(((((((((((((()))))))))))))).))))))....)))))))))..)))))..((((.))))((((((...........))).)))([((....((......(((....)))..........(((((((.....)))))))....)).....(((((((((((....)))))))))))...............(..((((((.(..(((((.......)))))(((..((((((.)))))).)))....).((][.[[[))....)))))).)...((((..(((...{..)))..)))).(((....))).))]]].]......((((((.((..]]]]..)))))))).....)}......))))..)))))))..((((.(.(((((....((.......))....)))))...)))).).)(((((.((((((..(((((((((.......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))...)))..))))))))))).....(((((...(((((..(((((((.....(....)....)))))))((((((...((((...((((((((((((((.((((((((((....))))))))))..((((...}}.)))).....)))))))))..)))))...)))).))))))...((....((((..............))))....))..)))))...)))))..(..((((((((((.......)))))........(((((((..(..((...(((((..))))).))..).).))).)))....)))))).)))))))))))))).))))))))))))))).. Structure of the yeast mitochondrial ribosome - Class B; 21S ribosomal RNA 5mre aa 1501 3.75 RF00177,RF01959,RF01960 URS000060F99B_4932 28154081 0003735 0005840 4932 uaagaauaugauguugguucagauuaagcgcuaaauaaggacaugacacaugcgaaucauacguuuauuauugagauaauaaauaugugguguaaacgugaguaauuuuauuaggaauuaaugaacuauagaauaagcuaaauacuuaauauuauauaaaaaauuuauauaauaaaaaggauauauauauauauauuuaucuauagucaagccaauaaugguuuagguaguagguuuauuaagaguuaaaccuagccaacgauccauaaucgauaaugaaaguuagaacgaucacguugacucugaaauauagucaauaucuauaagauacagcagugaggaauauuggacaaugaucgaaagauugauccaguuacuuauuaggaugauauauauauauauauaaauugauuaaaaauaaaauccauaaauaauuaaaauaaugauauuaauuaccauauauuuauauggauauauauauauuuuaauaguccugacuaauauuugugccagcagucgcgguaacacaaagagggcgagcguuaaucauaaugguuuaaaggauccguagaaugaauuauauauaauuuagaguuaauaaaauuaauuaaagaauuauaauaguaaagaugaaauaauaauaauaauuauaagacuaauauaugugaaaauauuaauuaaauauuaacugacauugagggauuaaaacuagaguagcgaaacggauucgauacccguguaguucuaguaguaaacuaugaauacaauuauuuauaauauauauauaaauaauaaaugaaaaugaaaguauuccaccugaagaguacguuagcaauaaugaaacucaaaacaauagacgguuacagacuuaagcaguggagcauguuauuuaauucgauaauccacgacuaaccuuaccauauuuugaauauuauaauaauuauaauuauuauauuacaggcguuacauuguugucuuuaguucgugcugcaaaguuuuagauuaaguucauaaacgaacaaaacuccauauauauaauuuuaauuauauauaauuuuauauuauuuaauauaaagaaaggaauuaagacaaaucauaaugauccuuauaauauggguaauagacgugcuauaauaaaaugauaauaaaauuauauaaaauauauuuaauuauauuuaauuaauaauauaaaacauuuuaauuuuuaauauauuuuuuuauuauaaauaugaauuauaaucugaaauucgauuauaugaaaaaagaauugcuaguaauacguaaauuaguauguuacggugaauauucuaacuguuucgcacuaaucacucaucacgcguugaaacauauuauuaucuuauuauuuauauaauauuuuuuaauaaauauuauuaauuuauauuuauuuauaucagaaauaauaugaauuaaugcgaaguugaaauacaguuaccguaggggaaccugcggugggcuuauaaauaucuuaaauauucuuaca ...<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<......<<<.<<<..<<<..<<<<<<<<<<<<..>>>>>>>>>>..>>>>>.....<<<........<<<<<.<<.........<<<<<<<<.<<<<.......>>>>...<<<<<<<<<...>>>>>>>>>......<<<<<<<<<..>>>>>>>>>.>>>>>>>>....>>>>>>><<<....<<<..<<<<<<<<........>>>>>>>>>>>......>>>..<<<<.<<<<....>>>>...>>>>.>>><<<<<<.........>>>>>><<<<.....>>>>..>>>>>>.........<<<....<<<<....>>>>..>>>...>.>>>>>>.<<<<..<<<<<<....>>>>>>..<<......>>.....>>>>..<<<<<<<<..............>>>>><<<<<<<..>>>>>>><<<<<..>>>>>>>>....<<<<<(((.....<<<<.....<<.)))>>.......>>>>.>>>>>..>>>>>>>>>.....<<<((.....<<<<...<.<<.<<<<<<..>>>>>>...<<<<<<<<...<<<<<<<<<<..<<<<<<<........................>>>>>>>..>>.......<<....>>.>>>>>>>>.>>>>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<.<..>..>>>>>>>>>>..<<..))>>....>>>>>>.>>>.<<.......<<<<....>>>>.....>>..)))).]<<.<<...<<<<.....<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<.....<<.<<<<<<<<<<..>>>>>>>>>>.>>.<<<.<<<..<<<<<<<<<....<<<<<<<<<....>>>....<<......>>....>>>>>>.....<<<.<<<<<<<<........>>>>>>>>..<<<<<<<<<..>>>>>>>>>....>>>.....>>>.>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<........<<<..<<..<<<<<<......>>>>>>..>>....>>>......>>>>>>......<<<<<........>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<.<<<<<.........>>>>>>>...........>>>>..>>..>>....<.<<<.<.<<<<<<<<..<<<<<<<<<.<<<...<<<..<<<.<<<<<...<<<<<<<...>>>>>>>...>>>>>>>>..>>>..>>>>>>>>>>>>..>>>>>>>>..>.>>>..>.....<<<<<<<<<....>>>>>>>>>............................. ...((((..[.[[[[.)))).((((.(((((..(((((((((....(((.(((..(((..(((((((((((....)))))))))..))))).....((((.......(((((.((...(...(.((((((((.((((.......))))...(((((((((...)))))))))......((((((.((())).)))))).))))))))).).)))))))(((....(((..((((((((........)))))))))))......)))..((((.((((....))))...))))))))((((((.........))))))(((((..).))))..)))))).).....(.(((...(((((....)))).))))).)).)))))).((((..((((((....))))))..((......)).....))))....(((((...(.......)....))))(((((((..)))))))(..(....)..))......((((([[[.....((((.....((.]]])).......)))).)))))..)))))))))...(.((([[...(.((((...(.((.((((((..))))))..(((((((((...((((((((((..(((((((....(...........).......)))))))..)).......((....)).)))))))).))))))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((.(((((((((((.().).))))))))))..((..]]))....)))))))))))((.......((((....)))).....))..]]]].]((.((...(..(......(((((..((((((((((......((........))........(.(((((((..(..((.((((((((((())))))))))).))).((.(((..(((((((((....(((((((((....)))....((......))....)))))).....(((.((((((((........))))))))..(((((((((..)))))))))....))).....))).)))...))))))))....))))))))..)).)))))))).(...(((.((........(((..((...(((((......)))))...))....)))......)).)))......(((((.(....).)))))......(....(((((((........)))))))....)..)..))))).....((.(((((.........)))))))...........)..)..))..))..(.(..((.(.((((((((..(((((((((.((....(((..(((.(((((...(((((((.())))))))...))))))))..)))...)))))))))))..))))))))..).))...)..)..(((((((((....)))))))))}............................ Structure of the yeast mitochondrial ribosome - Class B; 15S ribosomal RNA 5mre bb 76 3.75 RF00005 URS0000B21DDE_4932 28154081 0030533 0006412 4932 ggcuacguagcucaguugguagagcacaucacucauaaugauggggucacagguucgaaucccgucguagccacca <<<<.<<..<<<<........>>>>.<<<<<.......>>>>>......<.<<.......>>.>.>>.>>>>.... ((((.((..(((..........))).(((((.......)))))......(.((.......)).).)).)))).... Structure of the yeast mitochondrial ribosome - Class B; tRNA 5mrf A 2709 4.97 RF02541,RF02540,RF02540,RF02540 URS0000B21DE8_4932 28154081 0003735 0005840 4932 guagaauaauagauuugaaauauuuauuauauagauuuaaagagauaaucauggaguauaauaauuaaauuuaauuuaauauaacuauuaauagaagguuacuaauaaauuaauaauuaauuuuaaaaccuaaagguaaaccuuuauauuaauaauguuaugaauaauuauuaauaauaauaaacuaagugaacugaaacaucuaaguaacuuaaggauaagaaaucaacagagauauuaugaguauuggugagagaaaauaauaaaggucuaauaaguauuaugugaaaaaaauguaagaaaauaggauaacaaauucuaagacuaaauacuauuaauaaguauaguaaguaccguaagggaaaguaugaaaaugauuauuuuauaagcaaucaugaauauauuauauuauauuaaugauguaccuuuuguauaaugggucagcaaguaauuaauauuaguaaaacaauaaguuauaaauaaauagaauaauauauauauauaaaaaaauauauauuuaauuaauauuaauugacccgaaagcaaacgaucuaacuaugauaagauggauaaacgaucgaacagguugauguugcaauaucaucugauuaauugugguuaguagugaaagacaaaucugguuugcagauagcugguuuucuaugaaauauauguaaguauagccuuuauaaauaauaauuauuauauaauauauuauauaaagaaugguacagcaauuaauauauauuagggaacuaguuuuuuaauaauauuaaaucucgaaauauuuaauuauauauaauaaagagucagauuaugugcgauaagguaaauaaucuaaagggaaacagcccagauuaagauauaaaguuccuaauaaauaauaagugaaauaaauauuaaaauaaauauuuaaaaucaaauauauauauauuuguuaauagauaauauacggaucuuaauaauaagaauuauuuaauuccuuggaauauuauauuuuaaaauauaaauacugaauaucuaaauauuauuauuauaauaauaauaauaugguaauagaacauuuaaugauaauauauauuaguuauuaauuaauauauguauuaauuaaauagagaaugcugacaugaguaacgaaaaaaagguauaaaccuuuucaccuaaaacauaagguuuaacuauaaaaguacggccccuaauuaaauuaaauauaaauauauuuaagaugggauaaucuauauuaauauuuaucuuaaaauauauaauuauauuauauauuauauauuuauauaauauaaacuaauaaagaucaggaaaauuaauguauaccguaauguagaccgacucagguauguaaguagagaauaugaaggugaauuagauaauuaaagggaaggaacucggcaaagauagcucauaaguuagucaauaaagaguaauaagaacaaaguuguacaacuguuuacuaaaaacaccgcacuuugcagaaacgauaaguuuaaguauaaggugugaacucugcuccaugcuuaauauauaaauaaaauuauuuaacgauaauuuaauuaaauuuagguaaauagcagccuuauuaugaggguuauaauguagcgaaauuccuuggccuauaauugaggucccgcaugaaugacguaaugauacaacaacugucuccccuuuaagcuaagugaaauugaaaucguagugaagaugcuauguaccuucagcaagacggaaagacccuaugcagcuuuacuguaauuagauagaucgaauuauuguuuauuauauauaaugauaauucuaaucuuauacuuaauucuuaaguaauauauaauauauauauauauuauauauuauaagagacaaucucuaauugguaguuuugauggucauuaucagcaaaaguaucugaauaaguccauaaauaaauauauaaaauuauugaaaaaaauaauauauauuauauauauuaauuauaaauugaaauauguuuaauugaauauauuuuaguaauagauaaaaauauguacaguaaaauuguaaggaaaacaauaauaacuuucucggaaagaauuaaauuaauauaaugguauaacugugcgauaauuguaacacaaacgagugaaacaaguacguaaguauggcauaaugaacaaauaacacugauuguaaagguuauugauaacgaauaaaaguuacgcuagggaaggguaauauagcgaaagaguagauauuguaagcuauguuugccaccuucgacucaacauuuccucuugguuguaaaagcuaagaaggguuugacuguucgucaauuaaaauguuacgugaguuggguuaaauacgaugugaaucaguaugguuccuaucugcugaaggaaauauuaucaaauuaaaucucauuauuaguacgcaaggaccauaaugaaucaacccaugguguaucuauugauaauaauauaauauauuuauuaauauauuaucuauauuaguuuauauuuuaauuauuaucauaguagauaagcuaaguugauaauaaauaaauauugaauacauauuaaauaugaaguuguuuuaauaagauaauuaaucugauaauuuuauacuaaaauuaauaauuauagguuuuauauauuauuuauaauuauaauauuaauaaaauacuaauuuaucaguuaucuauauaauaucuaaucuauuauucuauau <<<<<<<<<<<<<<<.<<......<<<<<<<<<<<<.....<<<<<<<<<<<...<<<<....<<<<<<<<.>>>>>>>>...<<<<<<<<<<..<<<<.......<<<<<<<...>>>>>>>....>>>>..<<<....>>>....<<<<<<<<<..<....>..>>>>>>>>>.........<<<<<<.....<<....>>......>>>>>.>..<<.....<<....>>..<<<<<<.....<<.....>>....>>>>>>...<<<.........<<<<<<.......>>>>>>......<<<<..((((.>>>>..>>>....>>.>>>>>>>>.>>..........<<....>>....>>>>....>>>>>>>>>>>.......<<<<<.<<<<<<......>>>>>>.>>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<.....>>>....................<<<<.<......>.>>>>.......>>>>>>>>>>>>>..<<.<..<<<<<<<....<<<<<<<<<<..<<<<......>.>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>>...<<.....>>.......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<..<..<<<<<<<<<<<<<<<<..>>>>>>>>>..<<<<...<<<...<<<<<<<.<<<<<<<<<<<<>>>>>>>>>>>>>>>>>>>..>>.>...>>>>>>>>>>>...>.>>>>>>.>>..<<<<<<.<<<......>>>.>>>>>>....<<<......>>>...<<<.<<<<...<<<(((...<<<<<<<.....<<......<<<<<<<<<<..>>>>>.....<<<<<<<<..>>>>>>>>.>>>>>..........)))>>.............>>>>>>><<<<<..>>>>>.<<<<<<<<..>>>>>>>>..>>>...>>>>>>><<<<<<<<<<<<...>>>>>>>>>>>>....>>>>>>..<<<<<<......<<<<<<<<<<<...>>>>>>>>>>>......>>>>>>........>>>>>><......<<....<<<<<<......>>>>>><<<<<...<<<<<.<.............((..<<<.<<<...<<<...<..<<<<..>>>>>..>>>...>>>.....)).<<<<<<<.<<<.....<<.<<<......>>>.>>.<<<<<<<<<<<..>>>>>>>>>.[[..>>....>>>........>>>>>>>....>>>...>.....<<......>>>>>>>..<<<.....>>>..>>>>>..<<<<....<<<<<<<<.<<.................<<<....<.....>......>>>.............<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>..<<<<.<<<..<<<<<<<<.<<.....<.<<<<<<<<....>>>>>>>>>.....>>>>>>>>..>>>>><<<<<........>>>>>........<...........<<<<<.......>>>>>.....>....>>.>>..>>.>>>>>>......>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.<<<....<<<<<.<<<<<<..<<<<.<<<<<<<..<<<.<<<<<<<<<<<.<<.....>>>>>>>>>>>>>...<<<<<<<<<.<....>.>.>>.<<<<<<<<<<<<<..>>>>>>>>>>>>>.>>>>>>....>>>>>>>>>>..>>>>..<<<<.>>>><<<<<<...........>>>.>>>..<<....<<<.....<<<....>>>..........<<<<<<<.....>>>>>>>...>>>.....<<<<<<<<<<<....>>>>>>>>>>>.................<<<<<<<....<<<<<.......>>>>><<<..<<<<<<.>>>>>>.>>>......<<.[.(((>>....>>>>>>>....<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))].......<<<<<<.<<..))))..>>>>>>>>.............>>>>..>>>>>>>..<<<<.<.<<<<<....<<.......>>....>>>>>...>>>>.>..<<<<<..<<<<<..<<<<<<<<<.......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>......>>>.>>....<<<<<<<....>>>.>>>>...>>>..>>>>>>>>>>>.....<<<<<..<<<<<<..<<<<<<<...............>>>>>>><<<<<<....<<<..<<<<<<<<<<<<<<<.<<<<<<<<<<....>>>>>>>>>>..<<<<...]].>>>>.....>>>>>>>>>..>>>>>>..>>>..>>>>>>..<<<.<..<<<<<............>>>>>...>>>>.>>>>>>..>>>>>.....<<<<<<<<<<.......>>>>>........<<<<<<<<<<..<<...<<<<<..>>>>>.>>..>>>>>>>.>>>....>>>>>..>>>>>>>>>>>>>>.>>>>>>>>>>>>>>>.. (((((((((((((((.((......((((((((((((.....((((((((((....((((....((((((((.))))))))...(((((((((((.((((.......(((((((...)))))))....))))..(((....)))....(.(((((((..(....)..))))))).).........((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))....(((.........((((((.......))))))......((((..[[[[.))))..)))......))))))))).))..........((....))....)))).....)))))))))).....(.((((..((((((......))))))..)))).[.(.(........).).((((((..(.(((((((((((((..(((.....)))....................((((.(......).)))).......)))))))))))))..((.(...((((((.....((((((((((.((((......)[)))...(((..((((........)))).)))..).))))))))).(..((.....))....)..))))))......).))).((((((....(((((....)))))((((((((.....((((((((((((((((())))))))))...((....(((...(((((((.(((((((((.(())).)))))))))))))))..)).)....)).))))))).....)))))).))..((((((.(((......))).))))))....(((......)))...(((..(((...((([[[...(((((((.....((......((((((((((..))))).....((((((((..)))))))).)))))..........]]])).............)))))))(((((..))))).((((((((()))))))))..)))...))).)))((((((((((((...))))))))))))....))))))(.((((((......(((((((((((...)))))))))))......))))))..).....))))))(......((....((((((......))))))((((....((((..(..(.......)..[[...((.(((.(.(((.(.(..(((....)))).))))..)))).....]](.((((((.(((.(...((.(((..()..))).)).(((((((((((..))))))))).{{..))..).)))........))))))...).))....).....((......)).))))..((.......))...))))..((((....((((((((.((..(....(........((((....(.{...)......))).........)...((((((((.].((.........))...(((((((.....(((.....))).......))))))).}..((.(((..((((((((.(......(.((((((((....)))))))))......)))))))..)))))(((((........)))))........((..........(((((.......)))))..)..)....)).....)).))))))..)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.(((...((((((.((((((..(((((.((((((..(((.(((((((((((..(.....).)))))))))))...((((((..(.(....).)....(((((((((((((()))))))))))))).))))))....)))))))))..)))))..((((.))))((((((...........))).)))([((....((......(((....)))..........(((((((.....)))))))....)).....(((((((((((....)))))))))))...............(..((((((.(..(((((.......)))))(((..((((((.)))))).)))....).((][.[[[))....)))))).)...((((..(((...{..)))..)))).(((....))).))]]].]......((((((.((..]]]]..)))))))).....)}......))))..)))))))..((((.(.(((((....((.......))....)))))...)))).).)(((((.((((((..(((((((((.......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))...)))..))))))))))).....(((((...(((((..(((((((.....(....)....)))))))((((((...((((...((((((((((((((.((((((((((....))))))))))..((((...}}.)))).....)))))))))..)))))...)))).))))))...((....((((..............))))....))..)))))...)))))..(..((((((((((.......)))))........((((((((((..((...(((((..))))).))..))))))).)))....)))))).)))))))))))))).))))))))))))))).. Structure of the yeast mitochondrial ribosome - Class C; 21S ribosomal RNA 5mrf aa 1501 4.97 RF00177,RF01959,RF01960 URS000060F99B_4932 28154081 0003735 0005840 4932 uaagaauaugauguugguucagauuaagcgcuaaauaaggacaugacacaugcgaaucauacguuuauuauugagauaauaaauaugugguguaaacgugaguaauuuuauuaggaauuaaugaacuauagaauaagcuaaauacuuaauauuauauaaaaaauuuauauaauaaaaaggauauauauauauauauuuaucuauagucaagccaauaaugguuuagguaguagguuuauuaagaguuaaaccuagccaacgauccauaaucgauaaugaaaguuagaacgaucacguugacucugaaauauagucaauaucuauaagauacagcagugaggaauauuggacaaugaucgaaagauugauccaguuacuuauuaggaugauauauauauauauauaaauugauuaaaaauaaaauccauaaauaauuaaaauaaugauauuaauuaccauauauuuauauggauauauauauauuuuaauaguccugacuaauauuugugccagcagucgcgguaacacaaagagggcgagcguuaaucauaaugguuuaaaggauccguagaaugaauuauauauaauuuagaguuaauaaaauuaauuaaagaauuauaauaguaaagaugaaauaauaauaauaauuauaagacuaauauaugugaaaauauuaauuaaauauuaacugacauugagggauuaaaacuagaguagcgaaacggauucgauacccguguaguucuaguaguaaacuaugaauacaauuauuuauaauauauauauaaauaauaaaugaaaaugaaaguauuccaccugaagaguacguuagcaauaaugaaacucaaaacaauagacgguuacagacuuaagcaguggagcauguuauuuaauucgauaauccacgacuaaccuuaccauauuuugaauauuauaauaauuauaauuauuauauuacaggcguuacauuguugucuuuaguucgugcugcaaaguuuuagauuaaguucauaaacgaacaaaacuccauauauauaauuuuaauuauauauaauuuuauauuauuuaauauaaagaaaggaauuaagacaaaucauaaugauccuuauaauauggguaauagacgugcuauaauaaaaugauaauaaaauuauauaaaauauauuuaauuauauuuaauuaauaauauaaaacauuuuaauuuuuaauauauuuuuuuauuauaaauaugaauuauaaucugaaauucgauuauaugaaaaaagaauugcuaguaauacguaaauuaguauguuacggugaauauucuaacuguuucgcacuaaucacucaucacgcguugaaacauauuauuaucuuauuauuuauauaauauuuuuuaauaaauauuauuaauuuauauuuauuuauaucagaaauaauaugaauuaaugcgaaguugaaauacaguuaccguaggggaaccugcggugggcuuauaaauaucuuaaauauucuuaca ...<<<<..[.((((.>>>>.<<<<.<<<<<<.<<<<<<<......<<<.<<<..<<<..<<<<<<<<<<<<..>>>>>>>>>>..>>>>>.....<<<........<<<<<.<<.........<<<<<<<<.<<<<.......>>>>...<<<<<<<<<...>>>>>>>>>......<<<<<<<<<..>>>>>>>>>.>>>>>>>>....>>>>>>><<<....<<<..<<<<<<<<........>>>>>>>>>>>......>>>..<<<<.<<<<....>>>>...>>>>.>>><<<<<<.........>>>>>><<<<.....>>>>..>>>>>>.........<<<....<<<<....>>>>..>>>...>.>>>>>>.<<<<..<<<<<<....>>>>>>..<<......>>.....>>>>..<<<<<<<<..............>>>>><<<<<<<..>>>>>>><<<<<..>>>>>>>>....<<<<<(((.....<<<<.....<<.)))>>.......>>>>.>>>>>.>>>>>>>>>>.....<<<((.....<<<<...<.<<.<<<<<<..>>>>>>...<<<<<<<<...<<<<<<<<<<..<<<<<<<........................>>>>>>>..>>.......<<....>>.>>>>>>>>.>>>>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<.<..>..>>>>>>>>>>..<<..))>>....>>>>>>.>>>.<<.......<<<<....>>>>.....>>..)))).]<<.<<...<<<<.....<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<.....<<.<<<<<<<<<<..>>>>>>>>>>.>>.<<<.<<<..<<<<<<<<<....<<<<<<<<<....>>>....<<......>>....>>>>>>.....<<<.<<<<<<<<........>>>>>>>>..<<<<<<<<<..>>>>>>>>>....>>>.....>>>.>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<........<<<..<<..<<<<<<......>>>>>>..>>....>>>......>>>>>>......<<<<<........>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<.<<<<<.........>>>>>>>...........>>>>..>>..>>....<.<<<.<.<<<<<<<<..<<<<<<<<<.<<<...<<<..<<<.<<<<<...<<<<<<<...>>>>>>>...>>>>>>>>..>>>..>>>>>>>>>>>>..>>>>>>>>..>.>>>..>.....<<<<<<<<<....>>>>>>>>>............................. ...((((..[.[[[[.)))).((((.(((((..(((((((((....(((.(((..(((..(((((((((((....)))))))))..))))).....((((.......(((((.((...(...(.((((((((.((((.......))))...(((((((((...)))))))))......((((((.((())).)))))).))))))))).).)))))))(((....(((..((((((((........)))))))))))......)))..((((.((((....))))...))))))))((((((.........))))))(((((..).))))..)))))).).....(.(((...(((((....)))).))))).)).)))))).((((..((((((....))))))..((......)).....))))....(((((...(.......)....))))(((((((..)))))))(..(....)..))......((((([[[.....((((.....((.]]])).......)))).)))))..)))))))))...(.((([[...(.((((...(.((.((((((..))))))..(((((((((...((((((((((..(((((((....(...........).......)))))))..)).......((....)).)))))))).))))))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((.(((((((((((.().).))))))))))..((..]]))....)))))))))))((.......((((....)))).....))..]]]].]((.((...((((......(((((..((((((((((......((........))........(.(((((((..(..((.((((((((((())))))))))).))).((.(((..(((((((((....(((((((((....)))....(........)....)))))).....(((.((((((((........))))))))..(((((((((..)))))))))....))).....))).)))...))))))))....))))))))..)).)))))))).(...(((.((........(((..((...(((((......)))))...))....)))......)).)))......(((((.(....).)))))......(....(((((((........)))))))....)..)..))))).....((.(((((.........)))))))...........))))..))..))..(.(..((.(.((((((((..(((((((((.((....(((..(((.(((((...(((((((.())))))))...))))))))..)))...)))))))))))..))))))))..).))...)..)..(((((((((....)))))))))}............................ Structure of the yeast mitochondrial ribosome - Class C; 15S ribosomal RNA 5mrf bb 76 4.97 RF00005 URS0000B21DDE_4932 28154081 0030533 0006412 4932 ggcuacguagcucaguugguagagcacaucacucauaaugauggggucacagguucgaaucccgucguagccacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>......<.<<.......>>.>.>>>>>>>.... (((((((..(((..........))).(((((.......)))))......(.((.......)).).))))))).... Structure of the yeast mitochondrial ribosome - Class C; tRNA 5msf S 16 2.8 URS000080DDA4_32630 9808042,9461079,9245600,7523953,8254664 32630 cggaggaucaccacgg <<..<<....>>.>>. ((..((....)).)). MS2 PROTEIN CAPSID/RNA COMPLEX; 5'-R(*CP*CP*GP*GP*AP*GP*GP*AP*UP*CP*AP*CP*CP*AP*CP*GP*GP*G)-3' 5msg R 18 3.8 URS000080E01C_11520 28126917 11520 uauaccucugcuucugcu .................. .................. Influenza B polymerase bound to vRNA promoter and capped RNA primer; RNA (5'-R(*UP*AP*UP*AP*CP*CP*UP*CP*UP*GP*CP*UP*UP*CP*UP*GP*CP*U)-3') 5msg V 14 3.8 URS000080E200_11520 28126917 11520 aguaguaacaagag .<<....>>..... .((....))..... Influenza B polymerase bound to vRNA promoter and capped RNA primer; RNA (5'-R(P*AP*GP*UP*AP*GP*UP*AP*AP*CP*AP*AP*GP*AP*G)-3') 5mwi A 26 1.51 URS0000B21DD0_9606 28334744 9606 gcugcugcugcugcugcugcugcugc .......................... .......................... Crystal structure of G(CUG)8G duplex; RNA G(CUG)8C duplex 5myj AA 1535 5.6 RF00177,RF01959,RF01960 URS0000BC466A_416870 28959045 0003735 0005840 416870 uugagaguuugauccuggcucaggacgaacgcuggcggcgugccuaauacaugcaaguugagcgaugaagauuggugcuugcaccaauuugaagagcagcgaacgggugaguaacgcguggggaaucugccuuugagcgggggacaacauuuggaaacgaaugcuaauaccgcauaauaacuuuaaacauaaguuuuaaguuugaaagaugcaauugcaucacucaaagaugaucccgcguuguauuagcuaguuggugagguaaaggcucaccaaggcgaugauacauagccgaccugagagggugaucggccacauugggacugagacacggcccaaacuccuacgggaggcagcaguagggaaucuucggcaauggacgaaagucugaccgagcaacgccgcgugagugaagaagguuuucggaucguaaaacucuguugguagagaagaacguuggugagaguggaaagcucaucaagugacgguaacuacccagaaagggacggcuaacuacgugccagcagccgcgguaauacguaggucccgagcguuguccggauuuauugggcguaaagcgagcgcaggugguuuauuaagucugguguaaaaggcaguggcucaaccauuguaugcauuggaaacugguagacuugagugcaggagaggagaguggaauuccauguguagcggugaaaugcguagauauauggaggaacaccgguggcgaaagcggcucucuggccuguaacugacacugaggcucgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugagugcuagauguagggagcuauaaguucucuguaucgcagcuaacgcaauaagcacuccgccuggggaguacgaccgcaagguugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggucuugacauacucgugcuauuccuagagauaggaaguuccuucgggacacgggauacagguggugcaugguugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaaccccuauuguuaguugccaucauuaaguugggcacucuaacgagacugccggugauaaaccggaggaagguggggaugacgucaaaucaucaugccccuuaugaccugggcuacacacgugcuacaauggaugguacaacgagucgcgagacagugauguuuagcuaaucucuuaaaaccauucucaguucggauuguaggcugcaacucgccuacaugaagucggaaucgcuaguaaucgcggaucagcacgccgcggugaauacguucccgggccuuguacacaccgcccgucacaccacgggaguugggaguacccgaaguagguugccuaaccgcaaggagggcgcuuccuaagguaagaccgaugacuggggugaagucguaacaagguagccguaucggaaggugcggcuggauca ......((..<.<<<<.))...<<<<.<<<<<..<<<<<<<<.....<<<.<<<...<<..<<....<....................>......>>>>.......<<.......<<<<<<<...<<...<<......<.<<.....<...<......>...>......>>.>.....<<<...<<<......>>>...>>>......<<<<....>>>>.......>>..>>.>>>>>>><<<....<<<...<<<<<<<.......>>>>>>>.>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<.......................>>>>..<<..<<<.........<<<<<<<<..<.....>>>>>>>>>..........>>>.....>>.<<<<<<<<...((..(.....(..>>>.).......)..))>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<..........<<<<<<<.....>>>>>>>.......>>..>>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<..<...<<<......>>>......>..>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<...<<<<<<.......>>>>>>...>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..>>>>.><<<<<.<<<<<<<.....<<<<<..<<<.<<<<.......<<<........>>>.........<<<<<..........<<<<......<<<<<....>>>>>...............>>>>........<<......<<<<......<<<<<<.<<....>>.....<<.....>>.....>>>>>>.....<<<<.<<<.......<..............>........>>>.....<<<<<.....>>>>>........>>>>.......>.>>>.......>>........>>>.>>.....>>>>.>>>......<....<..........<..................>............>....>............<<<<<<<........>>>>>>>..........>>>>>.....<<<<<<<.........>>>>>>>...........>>>>>>>>>>.>>....<..<<...<<<<.<<<..<<<<<....<<<...<<.<<...<<<...<<....>>.>.>>..>>.>>..>>>....>>>>>..>>>.>>>>....>>...>.....<<<<<<<<<....>>>>>>>>>...... ......[...(.((((..]...((((.(((((..(((((((((....(((..((....(..((....(....................)......)))........(((......(((.(((...((...((......(.((.....(..(.(....).)..)......)).).....(...(.((........)).)...).....(.(((....))).)......))..)).))).)))(((....(((..((((((((.......)))))))))))......)))..(((((((......)))...))))))).(((((............))))).((((....))))...)).))).).....(.((....(((((....)))).).))).)).))))))..(((........(((....)).)......)))..(((.(((..........((...((.........))...))...........))).)...)).((((([[....((........((..]]))..........)))))))..)))))))))..........((([[...(.((((....((.(((((.(.(((((...........((.(((.....))).))........)))..))).)))))..((((.((((...((((((.(....((((.(....((........)).......).))))....).......((....))..))))))..))))..)))..)))....))))....((.(((...((...((((.........))))...))))).))......{...((((((..(.....(((((.......))))).....)...(...]].).....)))))))))).(.(......(((......)))....).)..)))).)((((..(((((((..(..(((.(..(((..(((((......((........))..........(((((.(..(.....(.(.(.....(((((....)))))..............).).)...)....(((........(.(....((((((.((....))......(......).....)))))).....(((..(.(((.....((..((.).....)))...[..))).)..(..((((.......)))).....)...))).....).)..........)))......).))).))..)).)))..))).(...(.(..(......(.(..((...(.(....).)...))..].).).......).).)......(....((.((((........)))).))....)..)..).))).....((((((...........))))))......)....))))))).)).))..(.(..((...((((.(.(...((((....(((....(.(..........((....))........).)...)))....))))...).).))))....))...)..)..(((((((((....)))))))))}..... Structure of 70S ribosome from Lactococcus lactis; 16S ribosomal RNA 5myj BA 2897 5.6 RF02540,RF02541,RF00002 URS0000BC468C_416870 28959045 0003735 0005840 416870 caaaguuaauaagggcgcacgguggaugccuuggcacuaagagccgaugaaggacgugacuaacgacgauauucuagggggagcaguaaguacgcauugaucccuaggucuccgaauggggaaacccagcuguuacuagcaguuauucaugagugaauacauagcucauguaaagguaacgcagagaacugaaacaucuaaguaccugcaggaagagaaaguaaaaacgauuucguaaguagcggcgagcgaacgcgaagaagggcaaaccaagaagcuugcuucuugggguuguaggacugcaacguggacuuaagcauuauagucgaauaaccugggaagguuaaucaaagaggguaauaaucccguagacaaaauagcgcuuauaccuagcaguauccugaguagggcuggacacgcgaaauccaguuugaauccgggaggaccaucucccaacccuaaauacuccuuagugaccgauagugaaccaguaccgugagggaaaggugaaaagaaccccgagaggggagugaaauagcaccugaaaccgugugccuacaagaaguucgagcccguuaaugggugagagcgugccuuuuguagaaugaaccggcgaguuacguuaugaugcgagguuaaguugaagagacggagccguagggaaaccgagucugaauagggcgacuuaguaucaugauguagacccgaaaccuagugaccuauccaugagcagggugaaggugugguaagacgcacuggaggcccgaaccaggacacguugaaaaguguuuggaugacuuguggauagcggagaaauuccaaacgaacugggagauagcugguucucuccgaaauagcuuuagggcuagcgucgaaauguaaguguauuggagguagagcacuguuugggugagggguccgucuaggauuaccaaucucagauaaacuccgaaugcuaauacacauguucggcagucagacugcgagugcuaagauccguagucgaaagggaaacagcccagaccaacagcuaaggucccaaaauauauguuaaguggaaaaggaugugggguugcacagacaacuaggauguuagcucagaagcagcuaucauucaaagagugcguaauagcucacuagucgagugacccugcgccgaaaauguaccggggcuaaacauauuaccgaagcuuuggauugauauuuuaucaaugguaggagagcguucuuaaccgcaaugaagguauaccgugaggagugcuggagcguuaagaagugagaaugccgguaugaguagcgcaagauaagugagaaucuuauccaccguaagacuaagguuuccaggggaaggcucguccgcccuggguuagucgggaccuaaggcgaggccgaaaggcguagucgauggacaacugguugauauuccaguacuagauaugaucgugauggagggacgcaguaggcuaagagaugccaguuaauggauccuggucuaagcagugaggugugagaugugucaaaugcauuucucucuaacauugagcugugauggggaagcaacuacgguugcgaacucucugaugucacacugccaagaaaagcuucuagcguaaagucauaucuacccguaccgcaaaccgacacagguagucgaggcgaguagccucaggugaucgagagaacucucguuaaggaacucggcaaaauagccccguaacuucgggagaaggggugcugguguaaaagccagccgcagugaauaggcccaagcaacuguuuaucaaaaacacagcucucugcuaaaccgcaaggugauguauagggggugacgccugcccggugcuggaagguuaagaggagugcuuagacguaagucgaagguaugaauugaagccccaguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgacccgcacgaaaggcguaaugauuugggcacugucucaacgagagacucggugaaauuuuaguaccugugaagaugcagguuacccgcgacaggacggaaagaccccauggagcuuuacuguaguuugauauugaguaccuguaagucauguacaggauagguaggagccauugaaauagggacgcuaguuucuauugaggcguuguugggauacuacccuugacuuaugguuacucuaacccgcuggcauaaucggccagggagacagugucugacggacaguuugacuggggcggucgccuccuaaagaguaacggaggcgcucaaagguuggcucagauugguuggaaaucaaucguagaguguaaagguaaaagccagcuugacugcgagagcuacaacucgagcagguaggaaacuaggacuuagugauccggugguaccgcauggaagggccaucgcucaacggauaaaagcuacccuggggauaacaggcuuaucucccccaagaguucacaucgacggggagguuuggcaccucgaugucggcucgucgcauccuggggcuguagucggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucccuauccgucgcgggcguagguaauuugagaggaucuguccuuaguacgagaggaccgggauggacuuaccgcugguguaccaguuguuccgccaggagcacggcuggauagcuauguagggaagggauaagcgcugaaagcaucuaagugcgaagcccaccucaagaugagauuacccauucguaagaauuaagagcccagagagaugaucugguagauaggcuggaaguggaagaguugcgagacuuggagcggaccaguacuaaucgcucgaggacuuuacc .<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.....((.>>>....<<<<<<<<..<<.))......>>.....>>>>>>>>..>>>....<<<....>>><<<<<<.....>>>>>>.<<<<<<<<<.........>>>>>>>.>>.>>...<<<<<......<<....>>.......>>>>.>.........<......>..<<<<<<.....<<.....>>....>>>>>>..(((....<<<<<<........>>>>>>......<<<<<<............<<<<<.<<...<<<....<<<<......>>>>.((......<<<.....))>>>...>>>.....>>.>>>>>........>>..>>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<....>>>>..................>>>>>>>>>>>.......<<<<..<<<<......>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>......>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<........>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<......<<<<<<<<<.....<<<...<<.<<<<<...<<..<<......>>....>>...>>>>>.>>..>>.>.....>>>>>>>>>...>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<...<<<<<<<<........<<<.<.<....<<...........>>....>.........<<......>>...>.>>>....>>>>>>>>..>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<.....>>>>>>....>>>>>>..<<<<..<.<<<......<<<<<.<<....>>.>>>>>...>>>.>.>>>>........>>>>>><<.....<.....<<<<<<.......>>>>>><<<<....<<<<..<<<..<<<<<<...<<.....>>.>>>>>>....((<<<<.<<.<.<<<...<<<....>>>...>>>..>>>....<<<<........>>>>.))<<<<<...........<<<<....<<<<...<...<<<<<...........{.............<<<<<.<<....<.<...<<<.....>>>..>.>........>>..>>>>>.....<...<<<<<....>>>>>...>>>>>>....>....>>>>.........>>>>..............>>>>>>>>>.>>>.....<<......>>.>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<........>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<..<<......>>..>>.>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>.>...>>......<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<......<<<...........<<.<<..<<<......<<<<...<....>...>>>>...>>>............>>.>>..>>>.....>>.>>>>>....<<.<<<<<.......>>>>>>>.....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<.<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>..>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.}..>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<....>>>....<<<<<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>...>>>>....>>>>>... .(((((......((((((((((.....(((..(((((((((((((......((((((.....[[.)))....(((((((...((.]]......))......)))))))..)))....(((....)))(.((((.....)))).).(((((((((.........))))))).)).))...(((((......(...[..).......)))).).........((....))...(((((.....((.]...))....)))))...((((...((((((........))))))....{.((((((.....(.......((((.((...(((...(((((......)))))[[(...).(((.....]])))...))).....)).))))...).....))..)))))....((((((((..[......))))))))....}.(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(.((...(((..[...)))...)).)...(.(........).).((((((....(((((((((((.(..(((...(((.....)))...)))...((....))..(.((.....)).)......).)))))))))))..((.(...((.(((.....((((((((((.(((....((((.(......).)))).....)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))).))......).))..((((((....(((((....)))))((((((((......(((((((.(.....(((...((((((.(...((...(.......)....))...).))))))..)).).....).)))))))...)))))).))..((((.((..(......)..)).))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(..(((.(.(.....{.((((.(.....(((.........)))..........(...((......)).).)))))...).).)))..).))...........]]].)...))))))))))...)))))))((((((.....))))))....))))))(.((((....(((.......(((..((....))].)))....)))...))))..).....))))))(......((....((((((.......))))))((((....(((...((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]]((((............(.((....(((((.(((..(((((...........{.........(...((((..((..(....(...((.....))..).........).))...))))....)(...(((((....)))))...))))))...)))..)))))(..).....)).)...............)))))))).))).....((......))..))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.[..).....)))))((((((......))))))(...).......(((((((((...((.........))...((.((((.....(((....))).......)))).)).]((((.(((..((.((((..(((....(...((.((..((......))..))..))...)....)))))))...)))))(.(((.........))).)........((.(......).(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).[..(((((......].)))).).((((((((.(((.((......((((.((((((..(((((.(.(.((.((.(((((.(...(.(.((.(.........(((((..(((......((((..((....).).))))...)))............)))))).)).).)..)..)))))....((.(((((.......))))))).....)).)).).)..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))).)..((((..(((...{..)))..)))).(((....))).))]]].].....((.(((..((..]]]]..)).))).)).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((.(((..(((((((((......))))))..))).(((((.....))))).....))).)..)...))).).....(((((((....))).))))....))..)))))))))))[...((((((....((((..((.(((......(....).....))).)).(((((...((((...(((((((((((.}..))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..].....))))))(.(((....)))....(((((((((.......)))))....((((((((..(.....(((((....)))))....)...))))).)))...))))...))))))... Structure of 70S ribosome from Lactococcus lactis; 23S ribosomal RNA 5myj BB 115 5.6 RF00001 URS0000BC468F_416870 28959045 0003735 0005840 416870 uugguauuaauugcauaggagauauaccuguucccaugucgaacacagaagucaaguccuauugcgcuggaaguacuuggggguugcccccugggagauaaagacgaugccaagu <<<<<<<<....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<.......<<.<<<<<...>>>>>.>>.......>>..>>>>>>>>.. (((((((.....((((((((.....((((((...(.....)...))))..))....)))))).)).((.......((.(((((...))))).)).......))...))))))).. Structure of 70S ribosome from Lactococcus lactis; 5S ribosomal RNA 5n8l B 21 NA URS0000CBFF5F_32630 29449323 32630 uuaauuaucuauuccguacuu ..................... ..................... Structure of TRBP dsRBD 1 and 2 in complex with a 19 bp siRNA (Complex B); RNA (5'-R(*UP*UP*AP*AP*UP*UP*AP*UP*CP*UP*AP*UP*UP*CP*CP*GP*UP*AP*CP*UP*U)-3') 5n8l C 21 NA URS0000CBFF38_32630 29449323 32630 guacggaauagauaauuaauu ..................... ..................... Structure of TRBP dsRBD 1 and 2 in complex with a 19 bp siRNA (Complex B); RNA (5'-R(*GP*UP*AP*CP*GP*GP*AP*AP*UP*AP*GP*AP*UP*AP*AP*UP*UP*AP*AP*UP*U)-3') 5n8m B 21 NA URS0000CBFF5F_32630 29449323 32630 uuaauuaucuauuccguacuu ..................... ..................... Structure of TRBP dsRBD 1 and 2 in complex with a 19 bp siRNA (Complex A); RNA (5'-R(*UP*UP*AP*AP*UP*UP*AP*UP*CP*UP*AP*UP*UP*CP*CP*GP*UP*AP*CP*UP*U)-3') 5n8m C 21 NA URS0000CBFF38_32630 29449323 32630 guacggaauagauaauuaauu ..................... ..................... Structure of TRBP dsRBD 1 and 2 in complex with a 19 bp siRNA (Complex A); RNA (5'-R(*GP*UP*AP*CP*GP*GP*AP*AP*UP*AP*GP*AP*UP*AP*AP*UP*UP*AP*AP*UP*U)-3') 5nco A 2883 4.8 RF02540,RF02541 URS000080E25C_562 28524878 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggguuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>...[.....<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))....].]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<..>>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<..>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<.>>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<<.<<....>>..>>>>>>..>.....>>>>>>>>..>>>>><<<<<<...>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<..<<<............<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>.>>..>>>..>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))((((((((..)))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((()))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((()).))...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((.((((.)))).))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.....)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((..(................((...((......(((.((((....)))).)))...)).............)).......)..)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Quaternary complex between SRP, SR, and SecYEG bound to the translating ribosome; 23S rRNA 5nco B 120 4.8 RF00001 URS0000049E57_562 28524878 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Quaternary complex between SRP, SR, and SecYEG bound to the translating ribosome; 5S rRNA 5nd8 a 1542 3.7 RF00177,RF01959,RF01960 URS0000B21DF7_93061 28645916 0003735 0005840 93061 ggagaguuugauccuggcucaggaugaacgcuggcggcgugccuaauacaugcaagucgagcgaacggacgagaagcuugcuucucugauguuagcggcggacgggugaguaacacguggauaaccuaccuauaagacugggauaacuucgggaaaccguagcuaauaccggauaauauuuugaaccgcaugguucaaaagugaaagacggucuugcugucacuuauagauggauccgcgcugcauuagcuaguugguaagguaacggcuuaccaaggcaacgaugcauagccgaccugagagggugaucggccacacuggaacugagacacgguccagacuccuacgggaggcagcaguagggaaucuuccgcaaugggcgaaagccugacggagcaacgccgcgugagugaugaaggucuucggaucguaaaacucuguuauuagggaagaacauauguguaaguaacugugcacaucuugacgguaccuaaucagaaagccacggcuaacuacgugccagcagccgcgguaauacguagguggcaagcguuauccggaauuauugggcguaaagcgcgcguaggcgguuuuuuaagucugaugugaaagcccacggcucaaccguggagggucauuggaaacuggaaaacuugagugcagaagaggaaaguggaauuccauguguagcggugaaaugcgcagagauauggaggaacaccaguggcgaaggcgacuuucuggucuguaacugacgcugaugugcgaaagcguggggaucaaacaggauuagauacccugguaguccacgccguaaacgaugagugcuaaguguuaggggguuucccgccccuuagugcugcagcuaacgcauuaagcacuccgccuggggaguacgaccgcaagguugaaacucaaaggaauugacggggacccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaaaucuugacauccuuugacaacucuagagauagagccuuccccuucgggggacaaagugacagguggugcaugguugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuuaagcuuaguugccaucauuaaguugggcacucuaaguugacugccggugacaaaccggaggaagguggggaugacgucaaaucaucaugccccuuaugauuugggcuacacacgugcuacaauggacaauacaaagggcagcgaaaccgcgaggucaagcaaaucccauaaaguuguucucaguucggauuguagucugcaacucgacuacaugaagcuggaaucgcuaguaaucguagaucagcaugcuacggugaauacguucccgggucuuguacacaccgcccgucacaccacgagaguuuguaacacccgaagccgguggaguaaccuuuuaggagcuagccgucgaaggugggacaaaugauuggggugaagucguaacaagguagccguaucggaaggugcggcuggaucacc ...<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<<<.....<<........>>.....>>>>.>>>>>......<<........<<<<<<<..<<...<<<<<<<.<<<<.....<<.<<<....>>>.>>......>>>>......<<<<<<<<<....>>>>>>>>>......<<<<<<...>>>>>>.>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<<..............<.<.......>>...............>>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<<..<<<.<<<<<<<.<<<<<<<<<.......<<<<<<.....>>>>>>.....>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>.>..........<<....>>.>>>>>>>..>>>>>.>>>...>>>..>>>>>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<<.....>>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<.......<<<<<....>>>>>.....<<<....>>>.....>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<..<<<<<<<..<<<..<<......>>>>>...>>>>>>>.....<<<<<.....>>>>>.........>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<..<.<<<<<<<........>>>>>>>>...>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<..<<<<....<.<<<<..<<<..<<<...>>>.>>>.>>>>.>...>>>>..>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>........ ...((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((..((.....(((..(..)..))).....))..)))))......(((.......(((((((..((...(((((((.((((.....((.(((....))).))......))))......(((((((((....)))))))))......(((((.....))))).)))))))..))))))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....((((((.............(..(.......).)..............))))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......(.((((.....)))).)...).)))))))..)))))))))..(((..((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))))...))..))))...))))....((((((....(...((((.........))))...).))))))..........((((((..((((((((((((.......))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((......(((((....)))))......(......)....).)).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..((......)))))...)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((..((((....(.((((..(((..(((...))).))).)))).)...))))..))))))..))).))))..).))...)..)..(((((((((....)))))))))........ Hibernating ribosome from Staphylococcus aureus (Unrotated state); 16S ribosomal RNA 5nd8 A 2912 3.7 RF02540,RF02541,RF00002 URS0000B21DE4_93061 28645916 0003735 0005840 93061 uuaaguuauuaagggcgcacgguggaugccuuggcacuagaagccgaugaaggacguuacuaacgacgauaugcuuuggggagcuguaaguaagcuuugauccagagauuuccgaauggggaaacccagcaugaguuaugucauguuaucgauaugugaauacauagcauaucagaaggcacacccggagaacugaaacaucuuaguacccggaggaagagaaagaaaauucgauucccuuaguagcggcgagcgaaaugggaagagcccaaaccaacaagcuugcuuguugggguuguaggacacucuauacggaguuacaaaggacgacauuagacgaaucaucuggaaagaugaaucaaagaagguaauaauccuguagucgaaaauguugucucucuugaguggauccugaguacgacggagcacgugaaauuccgucggaaucugggaggaccaucuccuaaggcuaaauacucucuagugaccgauagugaaccaguaccgugagggaaaggugaaaagcaccccggaaggggagugaaauagaaccugaaaccgugugcuuacaaguagucagagcccguuaaugggugauggcgugccuuuuguagaaugaaccggcgaguuacgauuugaugcaagguuaagcaguaaauguggagccguagcgaaagcgagucugaauagggcguuuaguauuuggucguagacccgaaaccaggugaucuacccuuggucagguugaaguucagguaacacugaauggaggaccgaaccgacuuacguugaaaagugagcggaugaacugaggguagcggagaaauuccaaucgaaccuggagauagcugguucucuccgaaauagcuuuagggcuagccucaagugaugauuauuggagguagagcacuguuuggacgaggggccccucggguaccgaauucagacaaacuccgaaugccaauuaauuuaacuugggagucagaacaugggugauaagguccguguucgaaagggaaacagcccagaccaccagcuaaggucccaaaauauauguuaaguggaaaaggauguggcguugcccagacaacuaggauguuggcuuagaagcagccaucauuuaaagagugcguaauagcucacuagucgagugacacugcgccgaaaauguaccggggcuaaacauauuaccgaagcuguggauuguccuuuggacaaugguaggagagcguucuaagggcguugaagcaugaucguaaggacauguggagcgcuuagaagugagaaugccggugugagucgcgaaagacgggugagaaucccguccaccgauugacuaagguuuccagaggaaggcucguccgcucuggguuagucggguccuaagcugaggccgacaggcguaggcgauggauaacagguugauauuccuguaccaccuauaaucguuuuaaucgauggggggacgcaguaggauaggcgaagcgugcgauuggauugcacgucuaagcaguaaggcugaguauuaggcaaauccgguacucguuaaggcugagcugugauggggagaagacauugagucuucgagucguugauuucacacugccgagaaaagccucuagauagaaaauaggugcccguaccgcaaaccgacacagguagucaagaugagaauucuaaggugagcgagcgaacucucguuaaggaacucggcaaaaugaccccguaacuucgggagaaggggugcucuuuaggguuaacgcccagaagagccgcagugaauaggcccaagcgacuguuuaucaaaaacacaggucucugcuaaaccguaaggugauguauaggggcugacgccugcccggugcuggaagguuaagaggagugguuagcuucugcgaagcuacgaaucgaagccccaguaaacggcggccguaauaacgguccuaagguagcgaaauuccuugucggguaaguuccgacccgcacgaaaggcguaacgauuugggcacugucucaacgagagacucggugaaaucauaguaccugugaagaugcagguuacccgcgacaggacggaaagaccccguggagcuuuacuguagccugauauugaaauucggcacagcuuguacaggauagguaggagccuuugaaacgugagcgcuagcuuacguggaggcgcuggugggauacuacccuagcuguguuggcuuucuaacccgcaccacuuaucguggugggagacagugucaggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcucaaagguucccucagaaugguuggaaaucauucauagaguguaaaggcauaagggagcuugacugcgagaccuacaagucgagcagggucgaaagacggacuuagugauccggugguuccgcauggaagggccaucgcucaacggauaaaagcuaccccggggauaacaggcuuaucucccccaagaguucacaucgacggggagguuuggcaccucgaugucggcucaucgcauccuggggcuguagucggucccaaggguugggcuguucgcccauuaaagcgguacgcgagcuggguucagaacgucgugagacaguucggucccuauccgucgugggcguaggaaauuugagaggagcuguccuuaguacgagaggaccgggauggacauaccucugguguaccaguugucgugccaacggcauagcuggguagcuauguguggacgggauaagugcugaaagcaucuaagcaugaagccccccucaagaugagauuucccaacuucgguuauaagaucccucaaagaugaugagguuaauagguucgagguggaagcauggugacauguggagcugacgaauacuaaucgaucgaagacuuaau <<<<<<......<<<<<<<<<<<....{[[.(((<<<<<<<[[<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<<<<<<<<.........>>>>>>>.>>.>>....<<<<<......<<....>>.......>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..(((....<<<<<<<......>>>>>>>......<<<<<<<<<.....<<<..........<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>...>>>.>>>>>..>>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.)))..............<<....>>....]].........<<<<....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<......>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<.<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>.>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<...<<<<<<<<<.....<<<...<<<<<<<....<<..<<<...>>>..>>....>>>>>>>..>>.>.....>>>>.>>>>>..>>>>>>>.>>..<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<.<<<<<.......<<<<<..<....<<.........>>....>.......................>>>>>...>>>>>.>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<...>>>>>>>....>>>>>>..<<<<<<<.<<......<<<<<.<<....>>.>>>>>...>>.>>>>>>>........>>>>>><.....<<<....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<..........<<<...<<<<....<<<<...<<...<....<.<<......{....>>.>.<....<<<<...<<<.<<<<<<..<<.....>>.>>>>>>......>>>...>>>>.....>..........................>....>>...>>>>.........>>>>..>>>.....>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<.......>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<<.<<<<....>>>>.>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<..<<....>>...>>>>>...>>...>>>>>>>>..>>>>><<<<<......>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>>....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<<.<<<<.<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>.>>>>....<<.<<<<<<.....>>>>>>>>.....>>>>>>>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.}..>>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>.<<<....>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>. ((((((......((((((((((.....(((..(((((((((((((......((((((.[[..[[[)))...].((((((...(((]]..]].)))......))))))...)))....(((....)))(((((((......))))))).(((((((((.........))))))).)).))....(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...((((((.(....).))))))....[.(((((((((.................(((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))).).....)))))..)))))....(((((((...{.......)))))))....].(((((}.[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((..((((..[...))))..)))).A.(.(........).).((((((..(.(((((((.(((((..(((...(((.....)))...)))...((....))...(((.....)))......))))).)))))))..((.(...((((((.....((((((((((.(((....((((((......)))))).....)))...(((.(((((.......<))))))))..).))))))))).(.(((....[)))...).]))))))......).)))..(((((....(((((....)))))(((((((((...(((((((((.....(((...((((((((...(....((...))....)...))))))))..)).).....)))).)))))..))))))).))..((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((.(((((.......((.(..(.(...((.........))...).).......................).))...))))).)))).))...........]]].)...))))))))))...)))))))(((((((...)))))))....)))))..((((((((.((......(((((.((....))])))))...)).))))))).)......))))))(......((....((((((.......))))))((((...[((((..((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]]((((((............((...((((....(((((..((.....(.(..........{..)...........((((...(((.(((((((.((.....)))))))))......)))...))))...............................).....))..)))))(..).....))))..)).......)))))))))).))).....((......)).)))).(((.......)))..))))].((((....((((((((.((..(....(........((((....(.[..).....)))).(((((((.((((....)))).)))))))(...).......(((((((((...((.........))...(((((((.....(((....))).......))))))).]((((.(((..(((((((..(((...((...((((...((....))....))))...))...))))))))..)))))(((((......)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).[..(((((.....a].)))))..((((((((.(((.((......((((.((((((..(((((.(((((((((.((((.(((((((((((.([........(((((..(((......((((((((...]))))))))...)))............)))))).))))))))))).))))....((.((((((.....)))))))).....)))))))))..)))))..(((......[)))((((((..........])))))).[((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..)))))))))......}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}..))))))..)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))((((....)))....(((((((((.......)))))....(((.((((.(((....(((((....)))))...)))..))))..)))...))))...))))))). Hibernating ribosome from Staphylococcus aureus (Unrotated state); 23S ribosomal RNA 5nd8 B 114 3.7 RF00001 URS00003DF33D_93061 28645916 0003735 0005840 93061 ucuggugacuauagcaaggaggucacaccuguucccaugccgaacacagaaguuaaggucuuuagcgacgaugguagccaacuuacguuccgcuagaguagaacguugccaggc .<<.<..<.....<<<<<<<......<<<<<...............>>>..>>.....>>>>>.>><.....<.<.<.<............>.>...>>....>..>..>.>>. .(..(..(.....(((((((......((((((...(.....)...))))..)).....))))).))..........(.(............).)............)..)..). Hibernating ribosome from Staphylococcus aureus (Unrotated state); 5S ribosomal RNA 5nd9 a 1541 3.7 RF00177,RF01959,RF01960 URS0000018F6E_93061 28645916 0003735 0005840 93061 ggagaguuugauccuggcucaggaugaacgcuggcggcgugccuaauacaugcaagucgagcgaacggacgagaagcuugcuucucugauguuagcggcggacgggugaguaacacguggauaaccuaccuauaagacugggauaacuucgggaaaccguagcuaauaccggauaauauuuugaaccgcaugguucaaaagugaaagacggucuugcugucacuuauagauggauccgcgcugcauuagcuaguugguaagguaacggcuuaccaaggcaacgaugcauagccgaccugagagggugaucggccacacuggaacugagacacgguccagacuccuacgggaggcagcaguagggaaucuuccgcaaugggcgaaagccugacggagcaacgccgcgugagugaugaaggucuucggaucguaaaacucuguuauuagggaagaacauauguguaaguaacugugcacaucuugacgguaccuaaucagaaagccacggcuaacuacgugccagcagccgcgguaauacguagguggcaagcguuauccggaauuauugggcguaaagcgcgcguaggcgguuuuuuaagucugaugugaaagcccacggcucaaccguggagggucauuggaaacuggaaaacuugagugcagaagaggaaaguggaauuccauguguagcggugaaaugcgcagagauauggaggaacaccaguggcgaaggcgacuuucuggucuguaacugacgcugaugugcgaaagcguggggaucaaacaggauuagauacccugguaguccacgccguaaacgaugagugcuaaguguuaggggguuucccgccccuuagugcugcagcuaacgcauuaagcacuccgccuggggaguacgaccgcaagguugaaacucaaaggaauugacggggacccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaaaucuugacauccuuugacaacucuagagauagagccuuccccuucgggggacaaagugacagguggugcaugguugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuuaagcuuaguugccaucauuaaguugggcacucuaaguugacugccggugacaaaccggaggaagguggggaugacgucaaaucaucaugccccuuaugauuugggcuacacacgugcuacaauggacaauacaaagggcagcgaaaccgcgaggucaagcaaaucccauaaaguuguucucaguucggauuguagucugcaacucgacuacaugaagcuggaaucgcuaguaaucguagaucagcaugcuacggugaauacguucccgggucuuguacacaccgcccgucacaccacgagaguuuguaacacccgaagccgguggaguaaccuuuuaggagcuagccgucgaaggugggacaaaugauuggggugaagucguaacaagguagccguaucggaaggugcggcuggaucac ...<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<<<...<<<<........>>>>...>>>>.>>>>>......<<........<<<<<<<..<<...<<<<<<<.<<<<.....<<.<<<....>>>.>>......>>>>......<<<<<<<<<<..>>>>>>>>>>......<<<<<<...>>>>>>.>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.......<.<<<....<<<<....>>>>..>>>>.>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<<<<<<<..............<.<.......>>...............>>>>>>...>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<<..<<<.<<<<<<<.<<<<<<<<<.......<<<<<<.....>>>>>>.....>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>.>..........<<....>>.>>>>>>>..>>>>>.>>>...>>>..>>>>>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<<.....>>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).].<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<.......<<........>>..........<<<<<<<......<<<<.......<<<<<....>>>>>.....<<<....>>>.....>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<...<<...<<......>>.>>....>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>....>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>.........<.<<<<<<<........>>>>>>>>.........>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>.....<..<<...<<<<.<<<..<<<<<<..<<<<....<.<<<<..<<<..<<<...>>>.>>>.>>>>.>...>>>>..>>>>>>..>>>.>>>>....>>...>.....<<<<<<<<<....>>>>>>>>>....... ...((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((..((.....(((..(..)..))).....))..)))))......(((.......(((((((..((...(((((((.((((.....((.(((....))).))......))))......(((((((((....)))))))))......(((((.....))))).)))))))..))))))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....((((((.............(..(.......).)..............))))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......(.((((.....)))).)...).)))))))..)))))))))..(((..((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))))...))..))))...))))....((((((....(...((((.........))))...).))))))..........((((((..((((((((((((.......))))))))))))...((..]])).....)))))))))).(((.......(((....))).....)))...]]].](.(((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((......(((((....)))))......(......)....).)).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(.(((((..(((..((......)))))...))))).)..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...))))))))))..)..(.(..((.(.((((.(((..((((((..((((....(.((((..(((..(((...))).))).)))).)...))))..))))))..))).))))..).))...)..)..(((((((((....)))))))))....... Hibernating ribosome from Staphylococcus aureus (Rotated state); 16S ribosomal RNA 5nd9 A 2914 3.7 RF02540,RF02541,RF00002 URS000024712F_93061 28645916 0003735 0005840 93061 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Hibernating ribosome from Staphylococcus aureus (Rotated state); 23S ribosomal RNA 5nd9 B 114 3.7 RF00001 URS00003DF33D_93061 28645916 0003735 0005840 93061 ucuggugacuauagcaaggaggucacaccuguucccaugccgaacacagaaguuaaggucuuuagcgacgaugguagccaacuuacguuccgcuagaguagaacguugccaggc .<<.<..<.....<<<<<<<......<<<<<...............>>>..>>.....>>>>>.>><....<<...<.<............>.>....>>...>..>..>.>>. .(..(..(.....(((((((......((((((...(.....)...))))..)).....))))).))..........(.(............).)............)..)..). Hibernating ribosome from Staphylococcus aureus (Rotated state); 5S ribosomal RNA 5ndg 2 1688 3.7 RF01960,RF01959,RF00177 URS00005F2C2D_4932 29208708 0003735 0005840 4932 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...<<<<<.{.[[[[>>>>><<<<.<<<<<<...<.<...<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<..<<..<<....<<<.............<.....<<.<<<.....>>>.>>......>.........<<<<<..<<....>>..>>>>><...<<<<<<......(((((((.........>>>>>>.....>...<<<<..<<.......>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>..>>>..>....>.>.....<<<<<<<<....>>>>>.>>>......<<..<...........>..>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>>>>>.........<<<[[.....<.<<...<<<.<<....<<<<<<.<<<<.....>>>>.>>>>>>....<<..>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........<<<..<<<<<<<<.....))))))).>>>>>>>>.>>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..]]>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..]]]].}<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<.......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>>....>.>>>>>....>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<.<<..>>.>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>....... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((.............(.....((.(((.....))).))......).........(((((..((....))..)))))(.(.((((((......[[[[[[[(......).)))))).)...).(.((((..((.......)).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....((..(.(((..))).)...))......(.(.(...........))..).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((((...))))).)))))).....(())....(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(....((..((((.....]]]]]]].))))..))...).....))...(((..((.((...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)).))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((.(..(((((.((((((....))))))...)))))..).)).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...((.((((.(....).)))).))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>...... Crystal structure of geneticin (G418) bound to the yeast 80S ribosome; 18S ribosomal RNA 5ndg 1 3078 3.7 RF02540,RF02543 URS000061F377_4932 29208708 0003735 0005840 4932 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........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((......((((.(....).)))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((..(.((((((.((((((..(((..((((.......))))..)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((((((((((....((.(((((((.....(((....(((..(.((((...((((((.....)))))).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.......(((())))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.....)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........((((((...))))))....))....))...(((((........)))))]]((((..(((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((((.(.)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....))....(((((.....]..)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((...)))))))...(((((.....((((..((((........))))...........>...((((((....))))))..))))..))))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.............))))...)))).))))....))))))))...(.((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).)))).)..(((((.(..(.......)..).....(((((((((.(((....((((.(..(.((((..)..))).)..)))))...)))....)))).)))))..))))).. Crystal structure of geneticin (G418) bound to the yeast 80S ribosome; 25S ribosomal RNA 5ndg 3 121 3.7 RF00001 URS000055688D_4932 29208708 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of geneticin (G418) bound to the yeast 80S ribosome; 5S ribosomal RNA 5ndg 4 158 3.7 RF00002 URS00001BF64E_4932 29208708 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of geneticin (G418) bound to the yeast 80S ribosome; 5.8S ribosomal RNA 5ndg 6 1700 3.7 RF01960,RF01959,RF00177 URS00005F2C2D_4932 29208708 0003735 0005840 4932 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...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<.......>>...>>.>>......{{........[[[..{{..{{....[[[...............<.....<<.<<<.....>>>.>>......>.........<<<<<..<......>..>>>>>....((((((......<<<<<<<<<<<<..>>>>..............)))))).........<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<<<<....>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.{{....<<<<<<.<<..>>.>>>>>>....<<<<<<.....>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[[..((((((((....>>>>>>>>.)))))))).]]].....}}....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<......>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<.....>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((.......))...)){))......(((.......(((..((..((....(((...............((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[[[[[[[((((..)))).....(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(.(((((......)))).).)......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.((())).))))))....((((((.....))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(((..((((((((....]]]]]]]].)))))))).))).....))...(((..((.((...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)).))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.(..(((......((........))..........(((((.(....(((((........((.(((........))).))......)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)..).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...(((((...)))))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>........ Crystal structure of geneticin (G418) bound to the yeast 80S ribosome; 18S ribosomal RNA 5ndg 5 3127 3.7 RF02540,RF02543 URS000061F377_4932 29208708 0003735 0005840 4932 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........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((.((..(((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..)))..)).....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((......((((((....)))))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...(.((((.....)))).).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.......(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((......)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((..((((((....((.....))..)))))....[[(((.((...((....(((....)))........(.(......).)....))....))...(((((........)))))]]((((..(((((.(...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....).))..))).)))).))).))).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((..)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.....((.....((((....)))).....))..))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..((((((.(..)))))))....((((.....((((..(((.(......).)))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.............))))...)))).))))....))))))))...(((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).)))))).)(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Crystal structure of geneticin (G418) bound to the yeast 80S ribosome; 25S ribosomal RNA 5ndg 7 121 3.7 RF00001 URS000055688D_4932 29208708 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of geneticin (G418) bound to the yeast 80S ribosome; 5S ribosomal RNA 5ndg 8 157 3.7 RF00002 URS00001BF64E_4932 29208708 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>.................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....))))))))).................... Crystal structure of geneticin (G418) bound to the yeast 80S ribosome; 5.8S ribosomal RNA 5ndh A 16 1.81 URS0000BC4682_33072 28529131 33072 gnggggacgaccccgc <<<<<<....>>>>>> ((((((....)))))) The structure of the G. violaceus guanidine II riboswitch P2 stem-loop; RNA (5'-R(*GP*(CBV)P*GP*GP*GP*GP*AP*CP*GP*AP*CP*CP*CP*CP*GP*C)-3') 5ndh B 16 1.81 URS0000BC4682_33072 28529131 33072 gnggggacgaccccgc <<<<<<....>>>>>> ((((((....)))))) The structure of the G. violaceus guanidine II riboswitch P2 stem-loop; RNA (5'-R(*GP*(CBV)P*GP*GP*GP*GP*AP*CP*GP*AP*CP*CP*CP*CP*GP*C)-3') 5ndh C 16 1.81 URS0000BC4682_33072 28529131 33072 gnggggacgaccccgc <<<<<<....>>>>>> ((((((....)))))) The structure of the G. violaceus guanidine II riboswitch P2 stem-loop; RNA (5'-R(*GP*(CBV)P*GP*GP*GP*GP*AP*CP*GP*AP*CP*CP*CP*CP*GP*C)-3') 5ndh D 16 1.81 URS0000BC4682_33072 28529131 33072 gnggggacgaccccgc <<<<<<....>>>>>> ((((((....)))))) The structure of the G. violaceus guanidine II riboswitch P2 stem-loop; RNA (5'-R(*GP*(CBV)P*GP*GP*GP*GP*AP*CP*GP*AP*CP*CP*CP*CP*GP*C)-3') 5ndi A 20 2.57 URS0000BC4687_562 28529131 562 uuugcaggacgaccugnaaa <<<<<<<<....>>>>>>>> ((((((((....)))))))) The structure of the E.coli guanidine II riboswitch P1 stem-loop; RNA (5'-R(*UP*UP*UP*GP*CP*AP*GP*GP*AP*CP*GP*AP*CP*CP*UP*GP*(CBV)P*AP*AP*A)-3') 5ndi B 20 2.57 URS0000BC4687_562 28529131 562 uuugcaggacgaccugnaaa <<<<<<<<....>>>>>>>> ((((((((....)))))))) The structure of the E.coli guanidine II riboswitch P1 stem-loop; RNA (5'-R(*UP*UP*UP*GP*CP*AP*GP*GP*AP*CP*GP*AP*CP*CP*UP*GP*(CBV)P*AP*AP*A)-3') 5ndi C 20 2.57 URS0000BC4687_562 28529131 562 uuugcaggacgaccugnaaa <<<<<<<<....>>>>>>>> ((((((((....)))))))) The structure of the E.coli guanidine II riboswitch P1 stem-loop; RNA (5'-R(*UP*UP*UP*GP*CP*AP*GP*GP*AP*CP*GP*AP*CP*CP*UP*GP*(CBV)P*AP*AP*A)-3') 5ndi D 20 2.57 URS0000BC4687_562 28529131 562 uuugcaggacgaccugnaaa <<<<<<<<....>>>>>>>> ((((((((....)))))))) The structure of the E.coli guanidine II riboswitch P1 stem-loop; RNA (5'-R(*UP*UP*UP*GP*CP*AP*GP*GP*AP*CP*GP*AP*CP*CP*UP*GP*(CBV)P*AP*AP*A)-3') 5ndj 13 1508 3.15 RF00177,RF01959,RF01960 URS0000868551_300852 29208708 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucaccuccuu .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<........>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<......>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............. .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(.(((........))).).)))))......(((......((((((((..((...(((((((.(((((....((((........)))).....)))))....((((.(.(((....))).).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((....(((((((....)))))))...................))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..((...(((.....)))).)...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}............ Crystal structure of aminoglycoside TC007 in complex with 70S ribosome from Thermus thermophilus, three tRNAs and mRNA (soaking); 16S ribosomal RNA 5ndj 1G 1513 3.15 RF00177,RF01959,RF01960 URS0000868551_300852 29208708 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucaccuccuug .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<<..>>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>....<<<....>>>...>>>>>>>>.<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.............. .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((.(....).)))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))..........((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(.((((((..((((.((....)).))))....((......))...)))))).)).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((.......(((.....)))......))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....))))))))).............. Crystal structure of aminoglycoside TC007 in complex with 70S ribosome from Thermus thermophilus, three tRNAs and mRNA (soaking); 16S ribosomal RNA 5ndj 1H 2912 3.15 RF02540,RF02541,RF00002 URS0000868533_300852 29208708 0003735 0005840 300852 ggucaagaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaacggcccgcacgcgggccgaaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggauguuggcuuagaagcagccaucauuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucuugacc <<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.....>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....<<<<<<......>>>>>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<.<.<<.<<<......>>>..>>.>.>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<.....................>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<.<<<<<<<<<...........<<.<<..<<<<.....<<<<<<<<....>>>>>>>>..>>>>............>>.>>..>>>>>>>>>.>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<.......>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>>> .....(((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((((((((..).))))))))....(.(((((((((......(...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)..)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....((.((........)).))....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((.(.((...............)))..)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((.(.......(((((...............................(..............).)))))...).)))))))).))..........]]].)....))))))))))...)))))))(((((((.......)))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........((.......(......(.(...((....))...).)...).................))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(..................(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...))))..... Crystal structure of aminoglycoside TC007 in complex with 70S ribosome from Thermus thermophilus, three tRNAs and mRNA (soaking); 23S ribosomal RNA 5ndj 14 2909 3.15 RF02540,RF02541,RF00002 URS0000868533_300852 29208708 0003735 0005840 300852 ggucaagaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaacggcccgcacgcgggccgaaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggauguuggcuuagaagcagccaucauuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucuugacc .<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<..>>>>>>.>>....<<<<<.....<......>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<.....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>.>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....<<<<..........>>>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<.<<........>>..>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<......<.<<<<<.<<.....................>>.........<........>...>>>>>.>..>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<.......<........<<<<<<<..>>>>>>>.....>.................>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>....<.......>......<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>>. 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Crystal structure of aminoglycoside TC007 in complex with 70S ribosome from Thermus thermophilus, three tRNAs and mRNA (soaking); 23S ribosomal RNA 5ndj 16 122 3.15 RF00001 URS00005AB4A7_300852 29208708 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga ..<<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> ...((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).)))))))))). Crystal structure of aminoglycoside TC007 in complex with 70S ribosome from Thermus thermophilus, three tRNAs and mRNA (soaking); 5S ribosomal RNA 5ndj 1J 122 3.15 RF00001 URS00005AB4A7_300852 29208708 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga ..<<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> ..(((((((((((....((((((.(....(((((((...(.....)...))))..)))...).)))).))(((.......((.(((((....))))).)).......))).))))))))))) Crystal structure of aminoglycoside TC007 in complex with 70S ribosome from Thermus thermophilus, three tRNAs and mRNA (soaking); 5S ribosomal RNA 5ndj Y1 25 3.15 29208708 562 ggcaaggagguuuuuuuuuuuuuuu ......................... ......................... Crystal structure of aminoglycoside TC007 in complex with 70S ribosome from Thermus thermophilus, three tRNAs and mRNA (soaking); mRNA 5ndj W1 76 3.15 RF00005 URS00005AA258_562 29208708 0030533 0006412 562 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((........)))).(((((.......))))).....(((((.......)))))))))))).... Crystal structure of aminoglycoside TC007 in complex with 70S ribosome from Thermus thermophilus, three tRNAs and mRNA (soaking); tRNA-Phe 5ndj X1 76 3.15 RF00005 URS00005AA258_562 29208708 0030533 0006412 562 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).(((((.......))))).....(((((..]....)))))))))))).... Crystal structure of aminoglycoside TC007 in complex with 70S ribosome from Thermus thermophilus, three tRNAs and mRNA (soaking); tRNA-Phe 5ndj V1 76 3.15 RF00005 URS00005AA258_562 29208708 0030533 0006412 562 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<<...>>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((........)))).(((((.......))))).....(((((.......)))))))))))).... Crystal structure of aminoglycoside TC007 in complex with 70S ribosome from Thermus thermophilus, three tRNAs and mRNA (soaking); tRNA-Phe 5ndj Y4 25 3.15 29208708 562 ggcaaggagguuuuuuuuuuuuuuu ......................... ......................... Crystal structure of aminoglycoside TC007 in complex with 70S ribosome from Thermus thermophilus, three tRNAs and mRNA (soaking); mRNA 5ndj W4 76 3.15 RF00005 URS00005AA258_562 29208708 0030533 0006412 562 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).(((((.......))))).....(((((..]....)))))))))))).... Crystal structure of aminoglycoside TC007 in complex with 70S ribosome from Thermus thermophilus, three tRNAs and mRNA (soaking); tRNA-Phe 5ndj X4 76 3.15 RF00005 URS00005AA258_562 29208708 0030533 0006412 562 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).(((((.......))))).....(((((..]....)))))))))))).... Crystal structure of aminoglycoside TC007 in complex with 70S ribosome from Thermus thermophilus, three tRNAs and mRNA (soaking); tRNA-Phe 5ndj V4 76 3.15 RF00005 URS00005AA258_562 29208708 0030533 0006412 562 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((........)))).(((((.......))))).....(((((.......)))))))))))).... Crystal structure of aminoglycoside TC007 in complex with 70S ribosome from Thermus thermophilus, three tRNAs and mRNA (soaking); tRNA-Phe 5ndk 13 1508 2.95 RF00177,RF01959,RF01960 URS0000868551_300852 29208708 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucaccuccuu .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<........>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<.<......>.>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............. .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(.(((........))).).)))))......(((......((((((((..((...(((((((.(((((....((((........)))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((....((((((......))))))...................))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..((...(((.....)))).)...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}............ Crystal structure of aminoglycoside TC007 co-crystallized with 70S ribosome from Thermus thermophilus, three tRNAs and mRNA; 16S ribosomal RNA 5ndk 1G 1513 2.95 RF00177,RF01959,RF01960 URS0000868551_300852 29208708 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucaccuccuug .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>....<<......>>...>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.............. .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((.(....).)))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))..........((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(.((((((...(((.(......).))).....((......))...)))))).)).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((.......(((.....)))......))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((..........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....))))))))).............. Crystal structure of aminoglycoside TC007 co-crystallized with 70S ribosome from Thermus thermophilus, three tRNAs and mRNA; 16S ribosomal RNA 5ndk 1H 2912 2.95 RF02540,RF02541,RF00002 URS0000868533_300852 29208708 0003735 0005840 300852 ggucaagaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaacggcccgcacgcgggccgaaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggauguuggcuuagaagcagccaucauuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucuugacc <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<[[<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.....>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...(((....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>.]]...............<<....>>....]].........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....<<<<<<......>>>>>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<....<...........>....>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..((((...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.........<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<.<<<<<<<<<...........<<.<<..<<<<.....<<<<<<<<<..>>>>>>>>>..>>>>............>>.>>..>>>>>>>>>.>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<.(((..>>>>..)))>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))))>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<.......>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>>> .(...(((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((((((((..).))))))))....(.(((((((((......(...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)..)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....((.((........)).))....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((.(.((...............)))..)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......(((((...............................(..............).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((((((.((.(.........((.......(......(.(((.((....)).))).)...).................))).)).)))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(..................(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...))))...). Crystal structure of aminoglycoside TC007 co-crystallized with 70S ribosome from Thermus thermophilus, three tRNAs and mRNA; 23S ribosomal RNA 5ndk 14 2909 2.95 RF02540,RF02541,RF00002 URS0000868533_300852 29208708 0003735 0005840 300852 ggucaagaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaacggcccgcacgcgggccgaaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggauguuggcuuagaagcagccaucauuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucuugacc .<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<..>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<......<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>..>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....<<<<..........>>>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<.<<........>>..>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<......<.<<<<<.<<.....................>>.........<........>...>>>>>.>..>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<.......<........<<<<<<<..>>>>>>>.....>.................>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>....<.......>......<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>>. .....(((......((((((((((.....(((..((((((((((((......((((((.[[..[[[)))...].((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((......)))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((((((((..).))))))))....(.(((((((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))......((............)).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((.(.((.(..........)..)))..)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((((.((.....{..(((....(...................)...........(........)....)))....)).))))))).))..........]]].)....))))))))))...)))))))((((((.........))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((.(((((.(((.(..........(...............(..((((....))))...).....................).).))).))))).))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(...(.......)......(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))...))))..... Crystal structure of aminoglycoside TC007 co-crystallized with 70S ribosome from Thermus thermophilus, three tRNAs and mRNA; 23S ribosomal RNA 5ndk 16 122 2.95 RF00001 URS00005AB4A7_300852 29208708 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga ...<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>. ...((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).)))))))))). Crystal structure of aminoglycoside TC007 co-crystallized with 70S ribosome from Thermus thermophilus, three tRNAs and mRNA; 5S ribosomal RNA 5ndk 1J 122 2.95 RF00001 URS00005AB4A7_300852 29208708 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga ..<<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> ..(((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).))))))))))) Crystal structure of aminoglycoside TC007 co-crystallized with 70S ribosome from Thermus thermophilus, three tRNAs and mRNA; 5S ribosomal RNA 5ndk Y1 25 2.95 29208708 562 ggcaaggagguuuuuuuuuuuuuuu ......................... ......................... Crystal structure of aminoglycoside TC007 co-crystallized with 70S ribosome from Thermus thermophilus, three tRNAs and mRNA; mRNA 5ndk W1 76 2.95 RF00005 URS00005AA258_562 29208708 0030533 0006412 562 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((........)))).(((((.......))))).....(((((.......)))))))))))).... Crystal structure of aminoglycoside TC007 co-crystallized with 70S ribosome from Thermus thermophilus, three tRNAs and mRNA; tRNA-Phe 5ndk X1 76 2.95 RF00005 URS00005AA258_562 29208708 0030533 0006412 562 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).(((((.......))))).....(((((..]....)))))))))))).... Crystal structure of aminoglycoside TC007 co-crystallized with 70S ribosome from Thermus thermophilus, three tRNAs and mRNA; tRNA-Phe 5ndk V1 76 2.95 RF00005 URS00005AA258_562 29208708 0030533 0006412 562 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<.<...>.>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((........)))).(((((.......))))).....(((((.......)))))))))))).... Crystal structure of aminoglycoside TC007 co-crystallized with 70S ribosome from Thermus thermophilus, three tRNAs and mRNA; tRNA-Phe 5ndk Y4 25 2.95 29208708 562 ggcaaggagguuuuuuuuuuuuuuu ......................... ......................... Crystal structure of aminoglycoside TC007 co-crystallized with 70S ribosome from Thermus thermophilus, three tRNAs and mRNA; mRNA 5ndk W4 76 2.95 RF00005 URS00005AA258_562 29208708 0030533 0006412 562 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((........)))).(((((.......))))).....(((((.......)))))))))))).... Crystal structure of aminoglycoside TC007 co-crystallized with 70S ribosome from Thermus thermophilus, three tRNAs and mRNA; tRNA-Phe 5ndk X4 76 2.95 RF00005 URS00005AA258_562 29208708 0030533 0006412 562 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).(((((.......))))).....(((((..]....)))))))))))).... Crystal structure of aminoglycoside TC007 co-crystallized with 70S ribosome from Thermus thermophilus, three tRNAs and mRNA; tRNA-Phe 5ndk V4 76 2.95 RF00005 URS00005AA258_562 29208708 0030533 0006412 562 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((........)))).(((((.......))))).....(((((.......)))))))))))).... Crystal structure of aminoglycoside TC007 co-crystallized with 70S ribosome from Thermus thermophilus, three tRNAs and mRNA; tRNA-Phe 5ndv 1 3078 3.3 RF02540,RF02543 URS000061F377_559292 29208708 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccgggguccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguuugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggaacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..<<<..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<<.<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>>..>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<....<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<....<.<<<<<......>>>>>>......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<<..<<<...>>>>>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.........>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<..[...>>>...<<<<<<<..<<<<(((.....<<<<<<......<.....]....<<<.<<<<<<<<<<.......<<<<..>>>>...>>>>>>>>>>>>>..........))).>....>>>>>>.>>>>..>>>>>>><<<<<<<<<.....>>>>>>>>>....>>>>>><.<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..[[[..>>>>>><...<<<<<<...<<<<<<....<<<.....>>>....>>>>>>...>.>>>>>....><<<<<<<.....>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<...............>>>>><<.<<<<<<<<<<<...>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<..<<<<<<<<..<<<<<<<<<..>>>>>>>>>...<<<<<.....<<<<..<<<..........>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>...>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))......<<<<<<<..<<<<.))))))>>>>>>>>>>>.........>>>>..>>>>>>.......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<....<<<<<<<<<.]]]..>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>...<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.....................<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((..((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))..))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((...(((((((((((((((((((((((.......(((((((......(((..........))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...((((.)))).)))).)..)))..)).).....)))))....(((.((((.(......))))).)))......))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.((((()))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.....)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...((((((...((.....)).))))))....[[(((.((...((....(((....))).........(.((((.....).)).).)....))....))...(((((........)))))]]((((..(((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((.....))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((...)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.....((.....((((....)))).....))..))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((((..)))))))))....((((.....((((..(((..........)))...........>...(((((......)))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).))))).....(((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))....((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(((.((..)..).)))..)))))...)))....)))).)))))).))))).. Crystal structure of Paromomycin bound to the yeast 80S ribosome; 25S ribosomal RNA 5ndv 3 121 3.3 RF00001 URS000055688D_559292 29208708 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of Paromomycin bound to the yeast 80S ribosome; 5S ribosomal RNA 5ndv 4 157 3.3 RF00002 URS00001BF64E_559292 29208708 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>.................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....))))))))).................... Crystal structure of Paromomycin bound to the yeast 80S ribosome; 5.8S ribosomal RNA 5ndv 2 1712 3.3 RF01960,RF01959,RF00177 URS00005F2C2D_559292 29208708 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagguuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucuggagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucau ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<............>...>>.>>......{{........[[[..{{..{{....[[[..................<.....<<.<<<.....>>>.>>......>.........<<<<<..<......>..>>>>>[...((((((......<<<<<<<<<<<....>>>..............)))))).....]...<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<.......>>.>>>......<<..<...........>..>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..))))))]]]].........[[[{{.......{{...[[[.{{....<<<<<<.<<<<..............>>>>.>>>>>>.....<<<<<..>>>>>....<<<<<.<<.......<<...<.......>..<<<<...>>>>....>>......>>.>>..>>>.........[[[..((((((((....>>>>>>>>.)))))))).]]].....}}....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>.>.>>.......<<....>>...>>>>..>.>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<........<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>.<.<<.<<<..<<<<<<<<.....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>.....>>.>>>...>.>>>>>>>>....>.>>>>>......>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<......<<<.....>>>......>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>....... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..................(.....((.(((.....))).))......).........(((((............)))))(.(.((((((......[.[[[[[.((......)).....(......).)))))).)...).(.((((..(((.....))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(.(...(.())....).)........(.(...........))............((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((.(.............)))).)))))).....(((((..)))))....(((((.((.......((..((.......)).(((.....)))....))......)).))..)))........((......((.(((.....]]]]].].))).)).....)..)..))...(((..((.((...((((..((..((((((.....((........))........))))))..)).......((....))...))))..).)))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((....(.(....).)......)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...((((((.......((.....((..((((....))))..))....))........))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...((((...))))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>...... Crystal structure of Paromomycin bound to the yeast 80S ribosome; 18S ribosomal RNA 5ndv 5 3087 3.3 RF02540,RF02543 URS000061F377_559292 29208708 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacauggcugggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccgaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugaaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucgaacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagauuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu 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........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.((((((((...((.(((.(((...({((((......)))))[[(...).(((....}]])))....))).)))...))...)))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((...........(((((((((((((((((((((((.......(((((((......(((.(......).))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.(((((..(.(((..))).)))))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.......((((..))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((..((((((....((.....))..)))))....[[(((.((...((....(((....)))........(.(..........).)....))....))...(((((........)))))]]((((..(((.(.(...((((....))).....<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))....)....).)...))).)))).))).))).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((..)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...(......((((....))))......).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(.(((....))).)....((((.....((((..((((........))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......(..(.(.((((((...((.......))...))))))...))...)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.............))))...)))).))))....)))))))).......((((((.(((.((....((.(........((((((.....)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Crystal structure of Paromomycin bound to the yeast 80S ribosome; 25S ribosomal RNA 5ndv 7 121 3.3 RF00001 URS000055688D_559292 29208708 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((......(((((...(....)...))).)..).....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of Paromomycin bound to the yeast 80S ribosome; 5S ribosomal RNA 5ndv 8 158 3.3 RF00002 URS00001BF64E_559292 29208708 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of Paromomycin bound to the yeast 80S ribosome; 5.8S ribosomal RNA 5ndv 6 1683 3.3 RF01960,RF01959,RF00177 URS00005F2C2D_559292 29208708 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacaggggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuaacggggccuuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<..{.((((.>>>><<<<.<<<<<<.....<...<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<..<<..<<....<<<..............<.....<<.<<<.....>>>.>>......>.........<<<<<..<......>..>>>>>....<<<<<<......{..(((..<<......>>....<<......>>>>>>>>.........<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>..>>>..>....>.......<<<<<<<<<..>.>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>>.........<<<[[.....<.<<...<<<.<<....<<<<<<.<<..>>.>>>>>>..<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........<<<..<<<<<<<.......)))..}..>>>>>>>.>>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..]]>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..)))).}<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<......<<<<<........<<.<<<........>>>.>>......>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<<..>>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>>......>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<...>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...))[))......(((.......(((..((..((....(((..............((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((..............(((....))).....(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)....).).....(.((((.(.....).))).).)......(.(.(...........))..).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..[......((([[...(.(.((...(((.((....((((((.(.(.)).))))))..(((((.((.......((..((.......))..((.....)).....))......)).))..))).........(((..(.((((((.............)))))).).))).....))...(((..((..(...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)..))...))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..((((((((.(((........)))))))))))..)))...((..]]))...))...].))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((........(..(((........)))..)......)))))...((.((....(.((((((....((..(((((....)))..(.((......)))...))..))....(((((.((..((....(((((.((((((....))))))...)))))....)).))..(.((((((.....))))))....)..)))))....))).))).....)..)))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...(..(((...)))..)...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}........ Crystal structure of Paromomycin bound to the yeast 80S ribosome; 18S ribosomal RNA 5ndw 1 3090 3.7 RF02540,RF02543 URS000061F377_559292 29208708 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccgaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguuugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucgacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacuuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<<.<<<<<<<<<<<<<<<<<<<<.....<<<<......>>>>.(.......<<<......)>>>....>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<......>>>..................................<<<<<.<<<<<......<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<......>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>(><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<..<<.......>>..>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.........>>>>.>>>>.....>>>>>.>>>>>>>>.>>).<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<......<..........<<<.<<<<<<<<<<.......<<<<..>>>>...>>>>>>>>>>>>>..........))).>....>>>>>>.>>>>..>>>>>>><<<<<<<<<.....>>>>>>>>>....>>>>>>..<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<<<...>>.>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<...............>>>>><<.<<<<<<<<<<...>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.....<<.....<<<<....>>>>.....>>..>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<.>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<......>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<.}}}..>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((......((((.(....).)))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((((((((((....((.(((((((.....(((....(((..(.((((...(..(..........).).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.......((((..))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.....)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...((((((...((.....)).))))))....[[(((.((...((....(((....)))........((((((........))))))....))....))...(((((........)))))]]((((..(((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((((...))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.....((.....((((....)))).....))..))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.(.).)))))))....((((.....((((..((((........))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.............))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(.(.((..)..).).)..)))))...)))....)))).)))))).))))).. Crystal structure of aminoglycoside TC007 bound to the yeast 80S ribosome; 25S ribosomal RNA 5ndw 2 1770 3.7 RF01960,RF01959,RF00177 URS00005F2C2D_559292 29208708 0003735 0005840 559292 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...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[................<.....<<.<<<.....>>>.>>......>.........<<<<<..<<....>>..>>>>>[...((((((......<<<<<<<<<<<....>>>..............)))))).....]...<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<.<<.<<........>>.>>.>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.{{....<<<<<<.<<<<<....<.>.....>>>>>.>>>>>>....<<<<<<...........<.......>...........>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[[..((((((((....>>>>>>>>.)))))))).]]].....}}....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<.......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>.<.<<.<<<..<<<<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<..<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>........>>>>....>>>.>>>...>.>>>>>>>>....>.>>>>>....>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<.<<.........>>.>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>....... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((................((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[[[[[[[(.(....).).....(......).)))))).)...).(.((((..((.(....))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....((..(.(((............))).)...))......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((((.....().....))))).))))))....((((((...............................))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........((...((..((((....]]]]]]]].))))..))..)).....))...(((..((.((...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)).))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...(((((((.((.........)).)))))))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>...... Crystal structure of aminoglycoside TC007 bound to the yeast 80S ribosome; 18S ribosomal RNA 5ndw 3 121 3.7 RF00001 URS000055688D_4932 29208708 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of aminoglycoside TC007 bound to the yeast 80S ribosome; 5S ribosomal RNA 5ndw 4 158 3.7 RF00002 URS00001BF64E_4932 29208708 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of aminoglycoside TC007 bound to the yeast 80S ribosome; 5.8S ribosomal RNA 5ndw 5 3080 3.7 RF02540,RF02543 URS000061F377_559292 29208708 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccgaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccuguaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcacgcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>...{.....<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<.<<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]....}.............................<<....>>...............<<<......>>>..................................<<<<<.<<<<<......<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<<..<<<<.........>>>>>>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<......<..........<<<.<<<<<<<<<<.......<<<....>>>...>>>>>>>>>>>>>..........))).>....>>>>>>.>>>>..>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<......>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<..>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<...............>>>>><<.<<<<<<<<<<<..>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>>.<<<<<.......>>>>>.........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<..<<<<<<<<..<<<<<<<...>>>>>>>...<<<<<.....<<<<..<<<<........>>>>...............<<<<<......>>>>>..>>>>..>>>>>.....>>>>>>>>...>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<<...<<<<<<<<<<}}}.>>>>>..>>>>>..>>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.....................<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((.((((.((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..)).)))).....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((......((((((....)))))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.(((((..(((...........)))))))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.......((((..))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((....)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((..((((((....((.....))..)))))....[[(((.((...((....(((....)))........(((((......)))))....))....))...(((((........)))))]]((((..((((..(...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((..))))))))))).).))))))).))))(...)....))))))...))....)..)..))).)))).))).))).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((..)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...((.....((((....)))).....)).)))))..))))).((((.........)))).........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(.((((.(..))))).)....((((.....((((..(((.(......).)))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.............))))...)))).))))....))))))))......(((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).)))))).)(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Crystal structure of aminoglycoside TC007 bound to the yeast 80S ribosome; 25S ribosomal RNA 5ndw 6 1736 3.7 RF01960,RF01959,RF00177 URS00005F2C2D_559292 29208708 0003735 0005840 559292 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...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[...............<.....<<.<<.......>>.>>......>.........<<<<<..<<....>>..>>>>>....((((((......<<<<<<<<<<<....>>>..............)))))).........<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<<<<.<..........>.>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.{{....<<<<<<.<<<<.<<<<<.>>>>>.....>>>>.>>>>>>....<<<<<<........>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[[..((((((((....>>>>>>>>.)))))))).]]].....}}....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<..>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((...............(.....((.(((.....))).))......).........(((((..((....))..)))))(.(.((((((......[[[[[[[[((......)).....(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(.(((.(................).)).).)....(.(((.(...........)).))......)..((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((..(((((.)))))......))).))))))....((((((........))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(((..((((((((....]]]]]]]].)))))))).))).....))...(((..((.((...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)).))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.(..(((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)..).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...((((((..))))))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>........ Crystal structure of aminoglycoside TC007 bound to the yeast 80S ribosome; 18S ribosomal RNA 5ndw 7 121 3.7 RF00001 URS000055688D_4932 29208708 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of aminoglycoside TC007 bound to the yeast 80S ribosome; 5S ribosomal RNA 5ndw 8 158 3.7 RF00002 URS00001BF64E_4932 29208708 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of aminoglycoside TC007 bound to the yeast 80S ribosome; 5.8S ribosomal RNA 5nef A 18 1.91 URS0000BC4678_33072 28529131 33072 gguggggacgaccccanc <<<<<<<....>>>>>>> (((((((....))))))) The structure of the G. violaceus guanidine II riboswitch P1 stem-loop with guanidine; RNA (5'-R(*GP*GP*UP*GP*GP*GP*GP*AP*CP*GP*AP*CP*CP*CP*CP*AP*(CBV)P*C)-3') 5neo A 18 1.69 URS0000BC4678_33072 28529131 33072 gguggggacgaccccanc <<<<<<<....>>>>>>> (((((((....))))))) The structure of the G. violaceus guanidine II riboswitch P1 stem-loop; RNA (5'-R(*GP*GP*UP*GP*GP*GP*GP*AP*CP*GP*AP*CP*CP*CP*CP*AP*(CBV)P*C)-3') 5nep A 18 1.6 URS0000BC4678_33072 28529131 33072 gguggggacgaccccanc <<<<<<<....>>>>>>> (((((((....))))))) The structure of the G. violaceus guanidine II riboswitch P1 stem-loop with methylguanidine; RNA (5'-R(*GP*GP*UP*GP*GP*GP*GP*AP*CP*GP*AP*CP*CP*CP*CP*AP*(CBV)P*C)-3') 5neq A 18 1.69 URS0000BC4678_33072 28529131 33072 gguggggacgaccccanc <<<<<<<....>>>>>>> (((((((....))))))) The structure of the G. violaceus guanidine II riboswitch P1 stem-loop with aminoguanidine; RNA (5'-R(*GP*GP*UP*GP*GP*GP*GP*AP*CP*GP*AP*CP*CP*CP*CP*AP*(CBV)P*C)-3') 5nex A 18 1.72 URS0000BC4678_33072 28529131 33072 gguggggacgaccccanc <<<<<<<....>>>>>>> (((((((....))))))) The structure of the G. violaceus guanidine II riboswitch P1 stem-loop with agmatine; RNA (5'-R(*GP*GP*UP*GP*GP*GP*GP*AP*CP*GP*AP*CP*CP*CP*CP*AP*(CBV)P*C)-3') 5ngm Aa 1539 2.9 RF00177,RF01959,RF01960 URS0000070030_1280 28959035 0003735 0005840 1280 auggagaguuugauccuggcucaggaugaacgcuggcggcgugccuaauacaugcaagucgagcgaacggacgagaagcuugcuucucugauguuagcggcggacgggugaguaacacguggauaaccuaccuauaagacugggauaacuucgggaaaccggagcuaauaccggauaauauuuugaaccgcaugguucaaaagugaaagacggucuugcugucacuuauagauggauccgcgcugcauuagcuaguugguaagguaacggcuuaccaaggcaacgaugcauagccgaccugagagggugaucggccacacuggaacugagacacgguccagacuccuacgggaggcagcaguagggaaucuuccgcaaugggcgaaagccugacggagcaacgccgcgugagugaugaaggucuucggaucguaaaacucuguuauuagggaagaacauauguguaaguaacugugcacaucuugacgguaccuaaucagaaagccacggcuaacuacgugccagcagccgcgguaauacguagguggcaagcguuauccggaauuauugggcguaaagcgcgcguaggcgguuuuuuaagucugaugugaaagcccacggcucaaccguggagggucauuggaaacuggaaaacuugagugcagaagaggaaaguggaauuccauguguagcggugaaaugcgcagagauauggaggaacaccaguggcgaaggcgacuuucuggucuguaacugacgcugaugugcgaaagcguggggaucaaacaggauuagauacccugguaguccacgccguaaacgaugagugcuaaguguuaggggguuuccgccccuuagugcugcagcuaacgcauuaagcacuccgccuggggaguacgaccgcaagguugaaacucaaaggaauugacggggacccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaaaucuugacauccuuugacaacucuagagauagagccuuccccuucgggggacaaagugacagguggugcaugguugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuuaagcuuaguugccaucauuaaguugggcacucuaaguugacugccggugacaaaccggaggaagguggggaugacgucaaaucaucaugccccuuaugauuugggcuacacacgugcuacaauggacaauacaaagggcagcgaaaccgcgaggucaagcaaaucccauaaaguuguucucaguucggauuguagucugcaacucgacuacaugaagcuggaaucgcuaguaaucguagaucagcaugcuacggugaauacguucccgggucuuguacacaccgcccgucacaccacgagaguuuguaacacccgaagccgguggaguaaccuuuuaggagcuagccgucgaaggugggacaaaugauuggggugaagucguaacaagguagccguaucggaaggugcggcuggau .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<<<......................>>>>.>>>>>......<<........<<<<<<<..<<...<<<<<<<.<<<<.....<<<<<<....>>>>>>......>>>>......<<<.<...........>.>>>.......<....<...>...>..>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<.......<<<....>>>......>>>>....<<<<<<.......<.<<<<<<<........>>>>>>>.>........>>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<<..<<<.<<<<<<<.<<<<<<<<<.......<<<<<<.....>>>>>>.....>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>..>>>>>....<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<<....>>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<..<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<.......<<<<......<<<<<....>>>>>.....<<<<..>>>>....>>>.>..<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<..<.<<.........<<......>>.........>>>......<<<<.......>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>......<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>.......<..<.<<<..<<........>>..>>>>...>.....>>>>>.....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<..<<<<....<.<<<<..<<<..<<<...>>>.>>>.>>>>.>...>>>>..>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.... .....((((..[.[[[..)))).((((.(((((...((((((((....((.......(((..((..((........................))..)))))......(((.......(((((((..((...(((((((.((((.....((((((....))))))......))))......((.(.((........)).)).).........(......).....)))))))..))))))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....)))).......)).).....(.(((...((((......))).))))).)).))))).....((........((....)).......))......((((((...(.......(((((........))))).......)....))))))......(...([[[...(((((.....((.]]])).......))))))...)..)))))))))..........((([[...(.((((...(((.(((.(((.(((((((((.......((((((.....)))))).....)))))))..))))).)))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((....(...((((.........))))...).))))))......{...((((((..((((((((((((......))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..(((((..(((......((........))..........((((.((..(...(..((.(....(((((....)))))......((....))...).))...)).((.((....((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(.(...........((......))..........).).....((((.......))))........)))).....).).)))...))..))))....)).))))...)).)..))))).(...(((((((.....(((..((....((....))....))....))).....)))))))......(....(....((........))....)....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((..((((....(.((((..(((..(((...))).))).)))).)...))))..))))))..))).))))..).))...)..)..(((((((((....)))))))))}... 2.9S structure of the 70S ribosome composing the S. aureus 100S complex; 16S ribosomal RNA 5ngm AA 2905 2.9 RF02540,RF02541,RF00002 URS000026DEF9_1280 28959035 0003735 0005840 1280 uuaaguuauuaagggcgcacgguggaugccuuggcacuagaagccgaugaaggacguuacuaacgacgauaugcuuuggggagcuguaaguaagcuuugauccagagauuuccgaauggggaaacccagcaugaguuaugucauguuaucgauaugugaauacauagcauaucagaaggcacacccggagaacugaaacaucuuaguacccggaggaagagaaagaaaauucgauucccuuaguagcggcgagcgaaaugggaagagcccaaaccaacaagcuugcuuguugggguuguaggacacucuacggaguuacaaaggacgacauuagacgaaucaucuggaaagaugaaucaaagaagguaauaauccuguagucgaaaauguugucucucuugaguggauccugaguacgacggagcacgugaaauuccgucggaaucugggaggaccaucuccuaaggcuaaauacucucuagugaccgauagugaaccaguaccgugagggaaaggugaaaagcaccccggaaggggagugaaauagaaccugaaaccgugugcuuacaaguagucagagcccguuaaugggugauggcgugccuuuuguagaaugaaccggcgaguuacgauuugaugcaagguuaagcaguaaauguggagccguagcgaaagcgagucugaauagggcguuuaguauuuggucguagacccgaaaccaggugaucuacccuuggucagguugaaguucagguaacacugaauggaggaccgaaccgacuuacguugaaaagugagcggaugaacugaggguagcggagaaauuccaaucgaaccuggagauagcugguucucuccgaaauagcuuuagggcuagccucaagugaugauuauuggagguagagcacuguuuggacgaggggccgguuaccgaauucagacaaacuccgaaugccaauuaauuuaacuugggagucagaacaugggugauaagguccguguucgaaagggaaacagcccagaccaccagcuaaggucccaaaauauauguuaaguggaaaaggauguggcguugcccagacaacuaggauguuggcuuagaagcagccaucauuuaaagagugcguaauagcucacuagucgagugacacugcgccgaaaauguaccggggcuaaacauauuaccgaagcuguggauuguccuuuggacaaugguaggagagcguucuaagggcguugaagcaugaucguaaggacauguggagcgcuuagaagugagaaugccggugugaguagcgaaagacgggugagaaucccguccaccgauugacuaagguuuccagaggaaggcucguccgcucuggguuagucggguccuaagcugaggccgacaggcguaggcgauggauaacagguugauauuccuguaccaccuauaaucguuuuaaucgauggggggacgcaguaggauaggcgaagcgugcgauuggauugcacgucuaagcaguaaggcugaguauuaggcaaauccgguacucguuaaggcugagcugugauggggagaagacauugugucuucgagucguugauuucacacugccgagaaaagccucuagauagaaaauaggugcccguaccgcaaaccgacacagguagucaagaugagaauucuaaggugagcgagcgaacucucguuaaggaacucggcaaaaugaccccguaacuucgggagaaggggugcucuuuaggguuaacgcccagaagagccgcagugaauaggcccaagcgacuguuuaucaaaaacacaggucucugcuaaaccguaaggugauguauaggggcugacgccugcccggugcuggaagguuaagaggagugguuagcuucugcgaagcuacgaaucgaagccccaguaaacggcggccguauaacgguccuaagguagcgaaauuccuugucggguaaguuccgacccgcacgaaaggcguaacgauuugggcacugucucaacgagagacucggugaaaucauaguaccugugaagaugcagguuacccgcgacaggacggaaagaccccguggagcuuuacuguagccugauauugaaauucggcacagcuuguacaggauagguaggagccuuugaaacgugagcgcuagcuuacguggaggcgcuggugggauacuacccuagcuguguuggcuuucuaacccgcaccacuuaucguggugggagacagugucaggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcucaaagguucccucagaaugguuggaaaucauucauagaguguaaaggcauaagggagcuugacugcgagaccuacaagucgagcagggucgaaagacggacuuagugauccggugguuccgcauggaagggccaucgcucaacggauaaaagcuaccccggggauaacaggcuuaucucccccaagaguucacaucgacggggagguuuggcaccucgaugucggcucaucgcauccuggggcuguagucggucccaaggguugggcuguucgcccauuaaagcgguacgcgagcuggguucagaacgucgugagacaguucggucccuauccgucgugggcguaggaaauuugagaggagcuguccuuaguacgagaggaccgggauggacauaccucugguguaccaguugucgugccaacggcauagcuggguagcuauguguggacgggauaagugcugaaagcaucuaagcaugaagccccccucaagaugagauuucccaacuucgguuauaagaucccucaaagaugaugagguuaauagguucgagguggaagcauggugacauguggagcugacgaauacuaaucgaucgaagacuuaau 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((((((......((((((((((.....(((..((((((((.((.(......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))(((((((......))))))).(((((((.(.........).))))).)).).....(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...((((((((....))))))))......(((((((((...(((((.....)((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))).)))))..)))))....((((((....[........))))))......(((((].[[[[)))))..)))......))..)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).......((((..((((..[...))))..)))).<.(.(........).).((((((..(.(((((((.(((((..(((...(((.....)))...)))...((....))..((((.....)))).....))))).)))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)<)))...(((.(((((........))))))))..).))))))))).(.(((....[)))...).]))))))......).))).((((((....(.(((....))).)(.(((((((...(((((((((.....(((...((((((((...((.........))...))))))))..)).).....)))).)))))..)))))))..)..((((((((((......))))))))))....(((......)))...((.(.(((...((([[[...(.((((((.....(.....((..((((.(((((.....{.(..(....(...(...........)...).........................)..)...))))).)))).))...........]]].)...))))))))))...)))).)).((((((...)))))).....))))))(.(((((((.((......(((((.((....))])))))...)).)))))))..).....))))))(......((....((((((.......))))))((((....(((...((...((((((...((.....)).))))))....[[((((..(.(.(((...(((....)))...)))..))....(((((........)))))]]((((((............((...((((....(((((..((...(..............{...............(((...((..(((((((.((.....))))))))).......))...))).................................)....))..)))))(..).....))))..)).......))))))))))..)).....((......))..))).(((.......)))..))))...(((....((((((((.((..(....(.......(((((....(.[..).....)))))(((((((.(((......))).)))))))(...).......(((((((((.>.(...........)...(((((((.....(((....))).......))))))).]((((..((..(((((((..(((...((...(((((.............)))))...))...))))))))..)))).(((((.....))))).........(..........(((((.......)))))..).......))))...)).))))))).)..))).)))))))).))).)).....)..[..(((((.....>].)))))..((((((((.(((.((......((((.((((((..(((((.(((((((((.((((.(((((...(....[...........((..(.(.........(.(((...]))).)......).)............)).......)...))))).)))).....(.((((((.....)))))))......)))))))))..)))))..(((......[)))((((((..........]))))))([.(....((((((.(.(((((.........)))))...).((][.[[[))....))))))....((((..(((...{..)))..)))).(((....))).).]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}..))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))((((....)))....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))...))))))). 2.9S structure of the 70S ribosome composing the S. aureus 100S complex; 23S Ribosomal RNA 5ngm AB 115 2.9 RF00001 URS0000062A7E_1280 28959035 0003735 0005840 1280 ucuggugacuauagcaaggaggucacaccuguucccaugccgaacacagaaguuaagcuccuuagcgucgaugguagucgaacuuacguuccgcuagaguagaacguugccaggc <<<<<<<<<....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<......<<<.<<<<....>>>>.>>>......>>..>>>>>>>>>. (((.((.((....((((((((.....((((((...(.....)...))))..))....)))))).)).((.......((.((((....)))).)).......))..)).)).))). 2.9S structure of the 70S ribosome composing the S. aureus 100S complex; 5S Ribosomal RNA 5njt A 1544 3.8 RF00177,RF01959,RF01960 URS0000BC46A9_224308 28468753 0003735 0005840 224308 ggagaguuugauccuggcucaggacgaacgcuggcggcgugccuaauacaugcaagucgagcggacagaugggagcuugcucccugauguuagcggcggacgggugaguaacacguggguaaccugccuguaagacugggauaacuccgggaaaccggggcuaauaccggaugguuguuugaaccgcaugguucaaacauaaaagguggcuucggcuaccacuuacagauggacccgcggcgcauuagcuaguuggugagguaacggcucaccaaggcgacgaugcguagccgaccugagagggugaucggccacacugggacugagacacggcccagacuccuacgggaggcagcaguagggaaucuuccgcaauggacgaaagucugacggagcaacgccgcgugagugaugaagguuuucggaucguaaagcucuguuguuagggaagaacaagugccguucgaauagggcgguaccuugacgguaccuaaccagaaagccacggcuaacuacgugccagcagccgcgguaauacguagguggcaagcguuguccggaauuauugggcguaaagggcucgcaggcgguuucuuaagucugaugugaaagcccccggcucaaccggggagggucauuggaaacuggggaacuugagugcagaagaggagaguggaauuccacguguagcggugaaaugcguagagauguggaggaacaccaguggcgaaggcgacucucuggucuguaacugacgcugaggagcgaaagcguggggagcgaacaggauuagauacccugguaguccacgccguaaacgaugagugcuaaguguuaggggguuuccgccccuuagugcugcagcuaacgcauuaagcacuccgccuggggaguacggucgcaagacugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggucuugacauccucugacaauccuagagauaggacguccccuucgggggcagagugacagguggugcaugguugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuugaucuuaguugccagcauucaguugggcacucuaaggugacugccggugacaaaccggaggaagguggggaugacgucaaaucaucaugccccuuaugaccugggcuacacacgugcuacaauggacagaacaaagggcagcgaaaccgcgagguuaagccaaucccacaaaucuguucucaguucggaucgcagucugcaacucgacugcgugaagcuggaaucgcuaguaaucgcggaucagcaugccgcggugaauacguucccgggccuuguacacaccgcccgucacaccacgagaguuuguaacacccgaagucggugagguaaccuuuuaggagccagccgccgaaggugggacagaugauuggggugaagucguaacaagguagccguaucggaaggugcggcuggaucaccuccuu ...<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<<<...<<<<<....>>>>>...>>>>.>>>>>......<<........<<<<<<<..<<...<<<<<<<.<<<<.....<<<<<<....>>>>>>......>>>>.....<<<<<<<<<<....>>>>>>>>>>.....<<<<<<....>>>>>>.>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>..<<<<<<<<.......<<<<<<<<<<<.....>>>>>>>>>.>>.......>>>>>>...>>.<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<.......<<<<<<.....>>>>>>.....>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<......>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<....<<<<<....>>>>>....<<......>>.>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<..<<<<<<<..<<<..<<......>>>>>...>>>>>>>.....<<<<<.....>>>>>.........>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<..<<<<....<.<<<<..<<<..<<<...>>>.>>>.>>>>.>...>>>>..>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............. ...((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((..(((...(((((....)))))...)))..)))))......(((.......(((((((..((...(((((((.((((.....((((((....))))))......)))).....((((((((((....)))))))))).....((((((....)))))).)))))))..))))))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((..(...((((....))))...).))))..((((((((........(((.((((.(.....).)))).)).)........))))))...)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))...).)))))))..)))))))))..((((.((((...((((((((....(((((.(...((........))......).)))))....).......((....)).)))))))..))))..)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((......))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((.(((((......((........))..........(((((((..(...(((((((....(((((....)))))....)...........)))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..((......)))))...)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).))).)))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((..((((....(.((((..(((..(((...))).))).)))).)...))))..))))))..))).))))..).))...)..)..(((((((((....)))))))))}............ Structure of the Bacillus subtilis hibernating 100S ribosome reveals the basis for 70S dimerization.; 16S ribosomal RNA 5njt U 2923 3.8 RF02540,RF02541,RF00002 URS0000BC46AD_224308 28468753 0003735 0005840 224308 uuaaguuagaaagggcgcacgguggaugccuuggcacuaggagccgaugaaggacgggacgaacaccgauaugcuucggggagcuguaagcaagcuuugauccggagauuuccgaauggggaaacccaccacucguaauggagugguauccauaucugaauucauaggauaugagaaggcagacccggggaacugaaacaucuaaguacccggaggaagagaaagcaaaugcgauucccugaguagcggcgagcgaaacgggaucagcccaaaccaagaggcuugccucuugggguuguaggacacucuguacggaguuacaaaggaacgagguagaugaagaggucuggaaaggcccgccauaggagguaacagcccuguagucaaaacuucguucucuccugaguggauccugaguacggcggaacacgugaaauuccgucggaauccgggaggaccaucucccaaggcuaaauacucccuagugaccgauagugaaccaguaccgugagggaaaggugaaaagcaccccggaaggggagugaaagagauccugaaaccgugugccuacaaguagucagagcccguuaacgggugauggcgugccuuuuguagaaugaaccggcgaguuacgaucucgugcaagguuaagcagaagaugcggagccgcagcgaaagcgagucugaauagggcgcaugaguacguggucguagacccgaaaccaggugaucuacccauguccagggugaaguucagguaacacugaauggaggcccgaacccacgcacguugaaaagugcggggaugagguguggguaggggugaaaugccaaucgaaccuggagauagcugguucucuccgaaauagcuuuagggcuagccucaagguaagagucuuggagguagagcacugauuggacuaggggccccuaccggguuaccgaauucagucaaacuccgaaugccaaugacuuauccuugggagucagacugcgagugauaagauccguagucgaaagggaaacagcccagaccgccagcuaaggucccaaaguauacguuaaguggaaaaggauguggaguugcuuagacaaccaggauguuggcuuagaagcagccaccauuuaaagagugcguaauagcucacuggucgagugacucugcgccgaaaauguaccggggcuaaacguaucaccgaagcugcggacuguucuucgaacagugguaggagagcguucuaagggcugugaagccagaccggaaggacugguggagcgcuuagaagugagaaugccgguaugaguagcgaaagaggggugagaauccccuccaccgaaugccuaagguuuccugaggaaggcucguccgcucaggguuagucgggaccuaagccgaggccgaaaggcguaggcgauggacaacagguugauauuccuguaccaccuccucaccauuugagcaauggggggacgcaggaggauaggguaagcgcgguauuggauauccgcguccaagcaguuaggcugggaaauaggcaaauccguuucccauaagccugagcugugauggcgagcgaaauauaguagcgaaguuccugauuccacacugccaagaaaagccucuagcgaggugagaggugcccguaccgcaaaccgacacagguaggcgaggagagaauccuaaggugaucgagagaacucucguuaaggaacucggcaaaaugaccccguaacuucgggagaaggggugcucuguuagggugcaagcccgagagagccgcagugaauaggcccaggcgacuguuuagcaaaaacacaggucucugcgaagccguaaggcgaaguauaggggcugacgccugcccggugcuggaagguuaagaggagcgcuuagcguaagcgaaggugcgaauugaagccccaguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgacccgcacgaaaggcgcaacgaucugggcacugucucaacgagagacucggugaaauuauaguaccugugaagaugcagguuacccgcgacaggacggaaagaccccguggagcuuuacugcagccugauauugaauguugguacagcuuguacaggauagguaggagccuuggaaaccggagcgccagcuucgguggaggcaucggugggauacuacccuggcuguauugaccuucuaacccgccgcccuuaucgggcggggagacagugucaggugggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguucccucagaaugguuggaaaucauucgcagaguguaaaggcacaagggagcuugacugcgagaccuacaagucgagcagggacgaaagucgggcuuagugauccggugguuccgcauggaagggccaucgcucaacggauaaaagcuaccccggggauaacaggcuuaucucccccaagaguccacaucgacggggagguuuggcaccucgaugucggcucaucgcauccuggggcuguagucggucccaaggguugggcuguucgcccauuaaagcgguacgcgagcuggguucagaacgucgugagacaguucggucccuauccgucgcgggcgcaggaaauuugagaggagcuguccuuaguacgagaggaccgggauggacgcaccgcugguguaccaguuguucugccaagggcaucgcuggguagcuaugugcggacgggauaagugcugaaagcaucuaagcaugaagccccccucaagaugagauuucccauuccgcaaggaaguaagaucccugaaagaugaucagguugauaggucugagguggaaguguggcgacacauggagcugacagauacuaaucgaucgaggacuuaac <<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<.....((.>>>.....<<<<<<<..<<<)).....>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<<<<<<<<.........>>>>>>>.>>.>>....<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<......<<.....>>.....>>>>...(((....<<<<<<<<....>>>>>>>>......<<<<<<<<<.....<<<<.......<<<<<<<<<<.<<<.....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>.>>>>>..>>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<......>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<.<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>......>>>>>.>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>...>.>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<...<<<<<<<<<.....<<<...<<<<<<<<...<<<<<<<.....>>>>>.>>...>>>>>>>>..>>.>.....>>>>.>>>>>..>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<.........>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<...>>>>>>>....>>>>>>..<<<<<<<.<<......<<<<<.<<....>>.>>>>>...>>.>>>>>>>........>>>>>><......<<....<<<<<<.......>>>>>><<<<....<<<<<.<<<..<<<<<<...<<.....>>.>>>>>>....((<<<<.<<.<.<<<...<<<....>>>...>>>..>>>....<<<<........>>>>.))<<<<<.<<<<<<......<<...<<<<....<<<<..<<<..<<<.<.<<<.<...{.{....>.>>>.<<..<...<<<<<<<.<<<<<<<.<<.....>>>>>>>>>....>>>>>.>>..>...>><..<<...........>>...>>.>>>...>>>...>>>>.........>>>>..>>..>>>>>>>>>>>>>>>.>>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<....<<<<....>>>>...>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>..<<<<.<<<..<<<<<<<..<<<...<<...<<<<<<.<<....>>..>>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>...>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.(...<<<<<.......)>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<<.<<<.<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>.>>>....<<.<<<<<<.....>>>>>>>>.....>>>>>>>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.}.}>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>. ((((((......((((.(((((.....(((..(((((((((((((......((((((.....[[[)))...].((((((...(((]].....)))......))))))...)))....(((....)))(((((((......))))))).((((((((...........)))))).)).))....((((((.....(...[..)......)))))..)........((....))...((((......((.]...)).....))))...((((...((((((((....))))))))....{.(((((((((.....((((.......((((((((((.(((...(.((((......)))))[[(...).(((.....]])))...)))...)))))))))))))).)))))..)))))....((((((((..[......))))))))....}.(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((....))))............)).....))))).)))).....(.((((..((((..[...))))..))))...(.(........).).((((((....(((((((.(((((..(((...(((.....)))...)))...((....))..((((.....))))......))))).)))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...).)))...(((.(((((.......<))))))))..).))))))))).(.((.......))...)..))))))......).))..((((((....((((......)))).((((((((...(((((((((.....(((...((((((((...(((.(((.....))).).))...))))))))..)).).....)))).)))))..))))))).)...(((((((..(......)..)))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(.((((((((.....{.(((((.(((..(((.........)))..))).....(...((......)).).)))))...)))))))).).))...........]]].)...))))))))))...)))))))(((((((...)))))))....))))))(.(((((...((......(((((.((....))])))))...))...)))))..).....))))))(......((....((((((.......))))))((((....(((...((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))....((((........)))).]](((((.((((((......((...((((....((((..(((..(((.(.(((.......{......)))..(....(((..((((.(((((((.((.....)))))))))....))))...)))....).(..((...........))...)).)))...)))...))))(..).....))))..))..))))))))))))))).))).....((......))..))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.[..).....)))))(((((....((((....))))...)))))(...).......((((((.((...((.........))...(((((((.....(((....)))..{....))))))).]((((.(((..(((((((..(((...((...(((((..((....))...)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...))..)))))).)..))).)))))))).)))))).....)).[..(((((......].)))))..((((((((.(((.((......((((.((((((..(((((.((((((((..(((.((...((((((..(.........(((((..(((......((((.(((....))).))))...)))............))))))..))))))...)).)))....((.((((((...}.))))))))......))))))))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((.(((..(((((((((......))))))..))).(((((.....))))).....))).)..)...))).).....(((((((....))).))))..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...(.((...(((((((((((.}..))))))..)))))...)).).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((....)))).(..(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))..)))))))). Structure of the Bacillus subtilis hibernating 100S ribosome reveals the basis for 70S dimerization.; 23S ribosomal RNA 5njt V 112 3.8 RF00001 URS0000BC467F_224308 28468753 0003735 0005840 224308 ugguggcgauagcgaagaggucacacccguucccauaccgaacacggaaguuaagcucuucagcgccgaugguagucggggguuucccccugugagaguaggacgccgccaa <<<<<<<....<<<<<<<<.....<<<<<<.............>>>>..>>....>>>>>>.>>.<<.......<<.<<<<<...>>>>>.>>.......>>..>>>>>>>. (((((((....((((((((.....((((((...(.....)...))))..))....)))))).)).((.......((.(((((...))))).)).......))..))))))). Structure of the Bacillus subtilis hibernating 100S ribosome reveals the basis for 70S dimerization.; 5S ribosomal RNA 5nom A 18 1.93 URS0000BC4678_33072 28529131 33072 gguggggacgaccccanc <<<<<<<....>>>>>>> (((((((....))))))) The structure of the G. violaceus guanidine II riboswitch P1 stem-loop with guanidine; RNA (5'-R(*GP*GP*UP*GP*GP*GP*GP*AP*CP*GP*AP*CP*CP*CP*CP*AP*(CBV)P*C)-3') 5np6 A 29 3.6 28630923 83333 gauggauagccuucgggcuaucuauagaa ........<<<....>>>........... ........(((....)))........... 70S structure prior to bypassing; mRNA 5np6 B 76 3.6 RF00005 URS00008FED32_83333 28630923 0030533 0006412 83333 cggcacguagcgcagccgguagcgcaccgucaugccgugucgggggucggagguucaaauccucucgugccgacca <<<<<<<..<<<<........>>>>.<<<.<<.....>>.>>>.....<<<<<.......>>>>>>>>>>>>.... ((.((((..((((........)))).(((.(.......).)))........((.......))...)))).)).... 70S structure prior to bypassing; P-site tRNA-Gly 5np6 D 1539 3.6 RF00177,RF01959,RF01960 URS000080DDC0_562 28630923 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggaucaccuccu .......<<<<....((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<..........>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>....<<......<<<<....>>>>.....>>.....<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<..))).>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>.>..........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..))))..<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((((..........)))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..(.((......((((....)))).....)).)...(.(((((...(..(.((((((((.......)))))))).)...)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((.......(((....))).....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))....(....)...))))).))).((.(((...((((((.(....((((((.((....))....(((......)))...)))))).....((((.(((((((...((..((.......))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... 70S structure prior to bypassing; 16S ribosomal RNA 5np6 Y 2903 3.6 RF02540,RF02541 URS00021ED929_562 28630923 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaacccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccgggagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<<<<..>>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<...<........<<.....<...<<<.........>>>...>.........<<<......>>>.....>>....>...>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><<<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>.>>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<........>>>...>>>>>>...>>>...>>>.>........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<....<....>.....>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<<.<<....>>..>>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<..<<<<...........<<<.............<....<<......>>....>....................>>>..>>>>..>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>........<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.........<.<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>..>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.)))....(((((((...(((]]]..].))).......)))))).).)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((.......((((((((((((.(((...(((((......)))))[[......(((.....]])))...)))...))))))))))))....))))...)....(((((((...[.......)))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((((..)))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..(.(.......).).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((.(...((.((((.....))))..))...).)).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.((.....................................(((......))).....))...)))..))))).))...........]]].)...))))))))))...)))))))((((((.((....)).))))))....))))))(.(((((....((......((((((((....))))))))...))...)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]]((((((((((.((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....((((.((((((.((.....)))))))).)..)))...[))))...))(..(((........)))...))))))...)))...))))(..).....))))...)).....)))))))))).))).))).....((......)).)))).(((.......)))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((....(((....])))....)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(.(((.....]}.))).)..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.(((............(.....................(......)............................)...))).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....((.((((.((..]]]]..)))))).)).....)}......))))..))))))......(.((..(.((((((...((.......))...))))))...).))...)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)....))..)))))))))))[...(((((((...((((..((.((((.....(....)....)))).)).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((.((.....).)))(....((..(((((.......)))))....(((.((((..((....(((((....)))))...))...))))..))).....))..).))))))))). 70S structure prior to bypassing; 23S ribosomal RNA 5np6 Z 120 3.6 RF00001 URS00008116C5_562 28630923 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<<.....<<<<<<<.....<<<<<<...............>>>..>>>....>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. (.((((((((.....((.(((......(((((((...(.....)...))))..))).....)))..)).((.......((((((((...)))))))).......))...)))))))).). 70S structure prior to bypassing; 5S ribosomal RNA 5nrg X 2710 3.442 RF02540,RF02541 URS00001450D9_93061 28973455 0003735 0005840 93061 uuaaguuauuaagggcgcacgguggaugccuuggcacuagaagccaaugaaggacguuacuaacgacgauaugcuuuggggagcuguaaguaagcuuugauccagagauuuccgaauggggaaacccagcaugaguuaugucauguuaucgauauguauacauagcauaucagaaggcacacccggagaacugaaacaucuuaguacccggaggaagagaaagaaaauucgauucccuuaguagcggcgagcgaaacgggaagagcccaaaccaacaagcuugcuuguugggguugaggacacucuaugaguuacaaaggacgacauuagacgaaucaucuggaaagaugaaucaaagaagguaauaauccuguagucgaaaauguugucucucuugaguggauccugaguacgacggagcacgugaaauuccgucggaaucugggaggaccaucuccuaaggcuaaauacucucuagugaccgauagugaaccaguaccgugagggaaaggugaaaagcaccccggaaggggagugaaauagaaccugaaaccgugugcuuacaaguagucagagcccguuaaugggugauggcgugccuuuuguagaaugaaccggcgaguuacgauuugaugcaagguuaagcaguaaauguggagccguagcgaaagcgagucugaauagggcguuuaguauuuggucguagacccgaaaccaggugaucuacccuuggucagguugaaguucaggcugaauggaggaccgaaccgacuuacguugaaaagugagcggaugaacugaggguagcggagaaauuccaaucgaaccuggagauagcugguucucuccgaaauagcuuuagggcuagccucaagugaugauuauuggagguagagcacuguuuggacgaggggguuaccgaauucagacaaacuccgaaugccaauuaauuuaacuugggagucagaacaugggugauaagguccguguucgaaagggaaacagcccagaccaccagcuaaggucccaaaauauauguuaaguggaaaaggauguggcguugcccagacaacuagcucauagucgagugacacugcgccgaaaauguaccggggcuaaacauauuaccgaagcuguggauuguccuuggacaaugguaggagagcguucuaagggcguugaagcaugaucguaaggacauguggagcgcuuagaagugagaaugccggugugaguagcgaaagacgggugagaaucccguccaccgauugacuaagguuuccagaggaaggcucguccgcucuggguuagucggguccuaagcugaggccgacaggcguaggcgauggauaacagguugauauuccuguaccaccuauaaucguaaucgauggggggacgcaguaggauaggcgaagcgugcgauuggaugcacgucuaagcaguaaggcugaguauccgguacucgaggcugagcugugauggggagagagucguugauuucacacugccgagaaaagccucuagauagauaggugcccguaccgcaaaccgacacagguagucaagaugagaauucuaaggugagcgagcgaacucucguuaaggaacucggcaaaaugaccccguaacuucgggagaaggggugcucuuuaggguuaacgcccagaagagccgcagugaauaggcccaagcgacuguuuaucaaaaacacaggucucugcuaaaccguaaggugauguauaggggcugacgccugcccggugcuggaagguuaagaggagugguuagcugcgaagcuacgaaucgaagccccaguaaacggcggcccuaagguagcgaaauuccuugucggguaaguuccgacccgcacgaaaggcguaacgauuugggcacugucucaacgagagacucggugaaaucauaguaccugugaagaugcagguuacccgcgacaggacggaaagaccccguggagcuuuacuguagccugauauugaaauucuggcuuucuaacccgcaccacuuaucguggugggagacagugucaagcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcucaaagguucccucagaaugguuggaaaucauucauagaguguaaaggcauaagggagcuugacugcgagaccuacaagucgagcagggucgaaagacggacuuagugauccggugguuccgcauggaagggccaucgcucaacggauaaaagcuaccccggggauaacaggcuuaucucccccaagaguucacaucgacggggagguuuggcaccucgaugucggcucaucgcauccuggggcuguagucggucccaaggguugggcuguucgcccauuaaagcgguacgcgagcuggguucagaacgucgugagacaguucggucccuauccgucgugggcguaggaaauuugagaggagcuguccuuaguacgagaggaccgggauggacauaccucugguguaccaguugucgugccaacggcauagcuggguagcuauguguggacgggauaagugcugaaagcaucuaagcaugaagccccccucaagaugagauuucccaacuugguuauaagaucccucaaagaugaugagguuaauagguucgagguggaagcauggugacauguggagcugacgaauacuaaucgaucgaagacuuaauc <<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<.<<<<<<.......>>>>>>..>>.>>....<<<<<......<<....>>.......>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..(((....<<<<<<<......>>>>>>>......<<<<<<<<..............<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>.>.....>>>>>..>>>......<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<....>>>>..................>>>>>>>>>>>.......<<<<..<<<<......>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<.<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>.>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<.....>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<...<<<<<<<<<.....<<<...<<<<<<<..................>>>>>>>..>>.>.....>>>>.>>>>>..>>>>>>>.>>..<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<.<<<<........<<.........>>....>>>>.>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<..>>>>>>>....>>>>>>..<<<<<<<.<<......<<<<<.<<....>>.>>>>>...>>.>>>>>>>........>>>>>><......<<....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<.<.<<<...<<<....>>>...>>>..>>>...<<<<<........>>>>>))<<<<<<..........<...<<<<....<<<<...<<...<....<.<<....{.....>>.>.<...<...........<.<<.....>>.>..............>....>............>....>>...>>>>.........>>>.>.>.....>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<....>.>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<<.<<<<....>>>>.>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<..<<..<<<<<<<..<<<...<<...<<<<<<.<<.>>..>>>>>>...>>...>>>>>>>>..>>>>.............<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<.<<<<<<.<<<<.......>>>>....<<.<<<<<<.....>>>>>>>>.....>>>>>>.>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<...}>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<...>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>.. ((((((......((((((((((.....(((..((((((((.((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))(((..((......))..)))...(.(((...........))).)....))....(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((((.(......).)))))......((((((.(.................((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))).........).)))..))).)....(((((((...[.......)))))))......(((((].[[[[)))))..)))......))..)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((..((((..[...))))..)))).{.(.(........).).((((((....(((((((.(((((..(((...(((.....)))...)))...((....))...(((.....)))......))))).)))))))..((.(...((((((.....((((((((((.((((...((((.....))))...){)))...(((.(((((........))))))))..).))))))))).(.(((....[)))...).]))))))......).))..((((((....(((((....)))))(((((((((...(((((((((.....(((...((((((((................))))))))..)).).....)))).)))))..))))))).))..((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((.(((((.......................))))).)))).))...........]]].)...))))))))))...)))))))(((((((..)))))))....))))))(.(((((((.((......(((((.((....))])))))...)).)))))))..).....))))))(......((....((((((.......))))))((((....(((...((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]]((((.((.........(...((((....((((...((...(.(............<....................................................................))....))...))))(..).....))))..)....)).)))))))).))).....((......))..))).(((.......)))..))))..((((....((((((((.((..(....(.......((((.....(.[..)......))))((((((....(......)....))))))(...).......(((((((((.}.((.........))...(((((((.....(((....))).......))))))).]((((..((..((.((((..(((...((...(((((..((.))...)))))...))...)))))))...)))).............((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).[..(((((.....}].)))))..((((((((.(((.((......((((.((((((..(((((.((.((((((.(((.........)))....((..(.(((.....))).).)).....)))))).))..)))))..(((......[)))((((((..........]))))))([.(...(((((((...(((((.........))))).....(.][.[[[.)....)))))))...((((..(((...{..)))..)))).(((....))).).]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.>..))))))..)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))((((...)))....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))...))))))).. The crystal structure of the large ribosomal subunit of Staphylococcus aureus in complex with RB02; 23S ribosomal RNA 5nrg Y 114 3.442 RF00001 URS00003DF33D_93061 28973455 0003735 0005840 93061 ucuggugacuauagcaaggaggucacaccuguucccaugccgaacacagaaguuaaggucuuuagcgacgaugguagccaacuuacguuccgcuagaguagaacguugccaggc .<<.<..<.....<<<<<<<......<<<<<...............>>>..>>.....>>>>>.>><....<<...<.<............>.>....>>...>..>..>.>>. .(..(..(.....((((.((......((((((...(.....)...))))..)).....)).)).))........................................)..)..). The crystal structure of the large ribosomal subunit of Staphylococcus aureus in complex with RB02; 5S ribosomal RNA 5nrl 2 155 7.2 RF00004 URS000023C730_4932 28530653 0045131 0000348 0005686 4932 gaaucucuuugaaguguaguaucuguucuuuucaguguaacaacugaaaugaccuaggcucauacacauuuuuuggcaggacgggaagaggagacgucgcgacccucgcacgagucguucuugacuuggucgcuugauguuucuucuucccguuc ..............................<<<<<<......>>>>>><<<<<<..>>.>>>>................<<<<<<<<<<.<<<<<<<<<<<<.<<......<<<<<<....>>>>>>>>>>>>..>>>>>>>>.>>>>>>>>>>. ..............................((((((......))))))((((((())).))))...............(.(((((((((.((((((((((((.((.......(((((....))))).))))))..)))))))).))))))))).) Structure of a pre-catalytic spliceosome; U2 snRNA 5nrl 4 114 7.2 RF00015 URS00001143F5_4932 28530653 0017070 0000244,0000353 0005687,0046540 4932 auccuuaugcacgggaaauacgcauaucagugaggauucguccgagauuguguuuuugcugguugaaauaauuauaacuccucauggucagacuauguagggaauuuuuggaau ...................<<<<<.<<<.....<<<....>>>..>>>>>>>>.........................<<<<<<<<<<<.>>>>>>>.>>>>............ ...................(((((.(((.....(((....)))..))))))))..........................((((((.(((.))).))).)))............. Structure of a pre-catalytic spliceosome; U4 snRNA 5nrl 5 170 7.2 RF00020 URS000053F313_4932 28530653 0000244,0000353 0005682,0046540 4932 aagcagcuuuacagaucaauggcggagggaggucaacaucaagaacugugggcgccuauagaacuuauaacgaacaugguucuugccuuuuaccagaaccauccggguguugucuccauagaaacagguaaagcuguccguuacugugggcuugccauauuuuuuggaac ..<<<<<<<.<<<<.......<<<<..<<<<<.<<<<<<.<<<..<<<<<<<..>>>>>>>..>>>.........<<<<<<<<...........>>>>>>>>....>>>>>>>>>>>......<<<<......>>>>>>>>..>>>>>>>>.>>>............... ..(((((.(.((((........(((..((((..((((((((((..((.(.((())).).))..))).....(...((((((((...........)))))))).).))))))).))))......((((......)))))))...))))).)).)))............... Structure of a pre-catalytic spliceosome; U5 snRNA 5nrl 6 95 7.2 RF00026 URS00006184A9_4932 28530653 0030621 0000244,0000353 0005688,0046540 4932 guucgcgaacuucguggacauuuggucaauuugaaacaauacagagaucagcaguuccccugcauaaggaugaaccguucaaagagauuuguuuu <<<<<<<<<.>>>>>>>>>.........<<<......>>>....................................................... (((((((((.))))))))).........(((......)))....................................................... Structure of a pre-catalytic spliceosome; U6 snRNA 5nrl I 29 7.2 URS0000B21DEE_4932 28530653 4932 ucucuucucuuauuuacuaacaaaaucaa ............................. ............................. Structure of a pre-catalytic spliceosome; Yeast UBC4 gene for ubiquitin-conjugating enzyme 5ns3 C 34 2.4 URS0000CBFF53_274 29211987 274 ncgcaccugaccccaugccgaacucagaagugcg .<<<<<<<<...............>>>..>>>>> .(((((((((...(.....)...))))..))))) Crystal structures of Cy5 cyanine fluorophores stacked onto the end of double-stranded RNA; double-stranded RNA 5ns3 D 32 2.4 URS0000CBFF53_274 29211987 274 ncgcaccugacccaugccgaacucagagugcg .<<<<<<<<<............>>>>.>>>>> .(((((((((..(.....)...)))).))))) Crystal structures of Cy5 cyanine fluorophores stacked onto the end of double-stranded RNA; double-stranded RNA 5nwy M 75 2.9 RF00005 URS00004FF598_562 28556777 0030533 0006412 562 ugggguaucgccaagcgguaaggcaccggauucugauuccggcauuccgagguucgaauccucguaccccagcca <<<<<<<..<<<.........>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..(((.....[...))).(((((.......))))).....(((((..]....)))))))))))).... 2.9 A cryo-EM structure of VemP-stalled ribosome-nascent chain complex; Gln-tRNA 5nwy O 118 2.9 RF00001 URS0000049E57_562 28556777 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))). 2.9 A cryo-EM structure of VemP-stalled ribosome-nascent chain complex; 5S rRNA 5nwy N 2897 2.9 RF02540,RF02541 URS000080E25C_83333 28556777 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu 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((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((..((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))))))..)))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((((((.)))).))...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..((...........))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((.((....)).))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((.(((.(..(.(..........((((..(((.......((..(((....)))..))....)))............)))).).).)..))).)))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). 2.9 A cryo-EM structure of VemP-stalled ribosome-nascent chain complex; 23S rRNA 5nwy 0 1539 2.9 RF00177,RF01959,RF01960 URS000080DDC0_562 28556777 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<<....>>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>..<<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>>.<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<.<<....>>>.>>....<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((((....))))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....(((.((((.......)))).))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((.(......)).))....((....))..))))).))).((.((....((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..((.......))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...))..))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... 2.9 A cryo-EM structure of VemP-stalled ribosome-nascent chain complex; 16S rRNA 5nxt U 18 1.379 URS0000CBFF40_32630 29122970 32630 uguucucuacgaagaaca .................. .................. Wobble base paired RNA double helix; RNA (5'-R(*UP*GP*UP*UP*CP*UP*CP*UP*AP*CP*GP*AP*AP*GP*AP*AP*CP*A)-3') 5o2r A 2900 3.4 RF02540,RF02541 URS0000A76322_83333 28741611 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugucgaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccgggagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((...<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>.........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<<..>>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<.<<..>>.>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<...........<<.<<...<<<.........>>>...>>........<<<......>>>..>>.......>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<.<......>.>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>...<<<<........>>>>.))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<<.<<....>>..>>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<...<<<......<<..<<<......>>>..>>...>>>.............>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<.<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>...>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......(((((..[..[[[..)).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((.......(((((.((((((.(((...(((((......)))))[[......(((.....]])))...)))...)))))).)))))....))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(.((........))..)...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{....((.((.....................))........(((......)))..))......)))..))))).))...........]]].)...))))))))))...)))))))((((((.(......).))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..(((((.((((((...{{{.).))))).((...(((...((((((((((((.((.....))))))))))..))))..[)))....))(...((((....))))....))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((....(((....])))....)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((.(((((...(............(.......(.............(......)..........).................)...)...))))).)))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((.((..).).)))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Cryo-EM structure of the proline-rich antimicrobial peptide Api137 bound to the terminating ribosome; 23S ribosomal RNA 5o2r B 120 3.4 RF00001 URS00008116C5_83333 28741611 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. .(((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((.(((((...))))).)).......))...))))))))).. Cryo-EM structure of the proline-rich antimicrobial peptide Api137 bound to the terminating ribosome; 5S ribosomal RNA 5o2r a 1539 3.4 RF00177,RF01959,RF01960 URS000080DDC0_83333 28741611 0003735 0005840 83333 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<..<....>..>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<......>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<........<<<<<<<<.<...>.>>>>>>>>..........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>.>..........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((............))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((.(.(((((((((.......((((((.....)))))).....)))))))..))).)))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...((((((....))))))..............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..((.......))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...((((((......(((..((...(((....)))...))....)))......))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((.((((....(((((..((((..((....)).)))).)))))...)))).)))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Cryo-EM structure of the proline-rich antimicrobial peptide Api137 bound to the terminating ribosome; 16S ribosomal RNA 5o2r x 77 3.4 RF00005 URS00000FF435_83333 28741611 0030533 0006412 83333 aggcuuguagcucaggugguuagagcgcaccccugauaagggugaggucggugguucaaguccacucaggccuacca <<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.........)))).(((((.......))))).....(((((.......)))))))))))).... Cryo-EM structure of the proline-rich antimicrobial peptide Api137 bound to the terminating ribosome; P-site Ile-tRNA 5o5j A 1511 3.45 RF00177,RF01959,RF01960 URS00001AF2F7_246196 28683309 0003735 0005840 246196 uuuggagaguuugauccuggcucaggacgaacgcuggcggcgugcuuaacacaugcaagucgaacggaaaggcccuuucggggguacucgaguggcgaacgggugaguaacacgugggugaucugcccugcacuuugggauaagccugggaaacugggucuaauaccgaauacacccugcuggucgcauggccugguaggggaaagcuuuugcggugugggaugggcccgcggccuaucagcuuguugguggggugauggccuaccaaggcgacgacggguagccggccugagagggugaccggccacacugggacugagauacggcccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagcgacgccgcgugagggaugacggccuucggguuguaaaccucuuucagcacagacgaagcgcaagugacgguaugugcagaagaaggaccggccaacuacgugccagcagccgcgguaauacguaggguccgagcguuguccggaauuacugggcguaaagagcucguaggugguuugucgcguuguucgugaaaacucacagcuuaacugugggcgugcgggcgauacgggcagacuagaguacugcaggggagacuggaauuccugguguagcgguggaaugcgcagauaucaggaggaacaccgguggcgaaggcgggucucugggcaguaacugacgcugaggagcgaaagcguggggagcgaacaggauuagauacccugguaguccacgccguaaacgguggguacuagguguggguuuccuuccuugggauccgugccguagcuaacgcauuaaguaccccgccuggggaguacggccgcaaggcuaaaacucaaaggaauugacgggggcccgcacaagcggcggagcauguggauuaauucgaugcaacgcgaagaaccuuaccuggguuugacaugcacaggacgccggcagagaugucgguucccuuguggccugugugcagguggugcauggcugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuugucucauguugccagcacguuaugguggggacucgugagagacugccggggucaacucggaggaagguggggaugacgucaagucaucaugccccuuauguccagggcuucacacaugcuacaauggccgguacaaagggcugcgaugccgugagguggagcgaauccuuucaaagccggucucaguucggaucggggucugcaacucgaccccgugaagucggagucgcuaguaaucgcagaucagcaacgcugcggugaauacguucccgggccuuguacacaccgcccgucacgucaugaaagucgguaacacccgaagccgguggccuaacccuuguggagggagccgucgaaggugggaucggcgauugggacgaagucguaacaagguagccguaccggaaggugcggcuggauc ......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<..<<<<<<<....>>>>>.>>>..>>>>>......<<........<<<<<<<..<<...<<<<<<<<<<<<.....<<<<<......>>>>>......>>>>.....<<<<<<<<<<<<..>>>>>.>>>>>>>....<<....>>>>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<<....>>.......>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<.....<<<<<<<.....>>>>>>>...>>>>>>>..>>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<<..<<<......>>>.....>>>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<.......>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>.<<.....>>.>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<<..<<<......>>>>>.....>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>......>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<..<<<<....<.<<<<..<<<..<<.....>>.>>>.>>>>.>...>>>>..>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... ......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((....))))).)))..)))))......(((.......(((((((..((...(((((((.((((.....((((((....))))))......)))).....(((((((((((....)))).)))))))....((....)).)))))))..))))))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(..((....))..)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((.....(((((((.....)))))))...))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((.(.......).))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((...(((((((....))))))).((.....))).))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((.(...((..(((......)))))....).)))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((..((...(((....)))...))....)))......)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((..((((....(.((((..(((..(((..).)).))).)))).)...))))..))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Structure of the 30S small ribosomal subunit from Mycobacterium smegmatis; 16S rRNA 5o5j W 19 3.45 RF00005 URS0000BC466E_246196 28683309 0030533 246196 aggggauugaaaauccccg .<<<<<<.....>>>>>>. .(((((.......))))). Structure of the 30S small ribosomal subunit from Mycobacterium smegmatis; tRNA-Phe anticodon stem 5o60 A 3119 3.18 RF02540,RF02541 URS0000BC467B_246196 28683309 0003735 0005840 246196 aaguguuuaagggcgcaugguggaugccuuggcacugggagccgaugaaggacguaggaggcugcgauaagccucggggagcugucaaccgagcguugauccgaggauguccgaauggggaaacccggcacgagugaugucgugucaccaggcgcugaauauauaggcgucuggggggaacgcggggaagugaaacaucucaguacccguaggaagagaaaacaaaaugugauuccgugaguaguggcgagcgaaagcggaggauggcuaaaccguaugcaugugauaccggguagggguugugugugcgggguugugggaccuaucuuuccggcucuaccuggcuggagggcagugagaaaauguugugguuagcggaaauggcuugggauggccugccguagacggugagagcccgguacgugaaaacccgacgucugucuugaugguguucccgaguagcagcgggcccguggaaucugcugugaaucugccgggaccacccgguaagccugaauacuucccagugaccgauagcggauuaguaccgugagggaauggugaaaaguaccccgggaggggagugaaagaguaccugaaaccgugcgcuuacaauccgucagagcccucgacgugucguggggugauggcgugccuuuugaagaaugagccugcgagucagggacaugucgcgagguuaacccgggugggguagccgcagcgaaagcgagucugaauagggcguauccacacaagagugugugguguagugguguguucuggacccgaagcggagugaucuacccauggccagggugaagcgcggguaagaccgcguggaggcccgaacccacuuagguugaagacugaggggaugagcuguggguaggggugaaaggccaaucaaacuccgugauagcugguucuccccgaaaugcauuuaggugcagcgucgcauguuucuugccggagguagagcuacuggauggccgaugggccccacaggguuacugacgucagccaaacuccgaaugccgguaaguccaagagugcggcagugagacggcgggggauaagcuccgugcgucgagagggaaacagcccagaucgccggcuaaggccccuaagcgugugcuaaguggaaaaggaugugcagucgcgaagacaaccaggagguuggcuuagaagcagccacccuugaaagagugcguaauagcucacuggucaagugauugugcgccgauaauguagcggggcucaagcacaccgccgaagccgcggcagccaacguguuggcuggguaggggagcguccugcauccggugaagccgccgagugaucgagugguggagggugugggagugagaaugcaggcaugaguagcgauuaggcaagugagaaccuugcccgccgaaagaccaaggguuccugggccaggccaguccgcccagggugagucgggaccuaaggcgaggccgacaggcguagucgauggacaacggguugauauucccguacccguguaugugcguccaugaugaaucagcgguacuaaccauccaaaaccaccgugaccgcaccuuucgggguguggcguugguggggcugcaugggaccuucguugguaguagucaagcgauggggugacgcaggaagguagccguaccggucagugguaauaccgggguaagccuguagggagucagauagguaaauccgucuggcauauauccugagaggugaugcauagccgagugaggcgaauucggugauccuaugcugccgagaaaagccucuagcgaggacauacacggcccguaccccaaaccaacacagguggucagguagagaauacuaaggcguacgagugaacuaugguuaaggaacucggcaaaaugcccccguaacuucgggagaagggggacccacauggcguguaagccuuuacggcccaagcgugaguggguggcacaaaccagugagaagcgacuguuuacuaaaaacacagguccgugcgaagucgcaagacgauguauacggacugacgccugcccggugcuggaagguuaagaggacccguuaacucccuuugggggugaagcggagaauuuaagccccaguaaacggcggugguaacuauaaccauccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaacgacuucucaacugucucaaccauagacucggcgaaauugcacuacgaguaaagaugcucguuacgcgcggcaggacgaaaagaccccgggaccuucacuacaacuugguauuggugcucgauacgguuuguguaggauaggugggagacugugaagcucacacgccaguguggguggagucguuguugaaauaccacucugaucguauugggccucuaaccucggaccguauauccgguucagggacagugccugguggguaguuuaacuggggcgguugccuccuaaaauguaacggaggcgcccaaagguucccucaaccuggacggcaaucagguguugaguguaagugcacaagggagcuugacugcgagacggacaugucgagcagggacgaaagucgggacuagugauccggcaccucugaguggaaggggugucgcucaacggauaaaagguaccccggggauaacaggcugaucuuccccaagaguccauaucgacgggaugguuuggcaccucgaugucggcucgucgcauccuggggcuggagcaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguuuagaacgucgugagacaguucggucucuauccgccgcgcgcgucagaagcuugaggaaaccugucccuaguacgagaggaccgggacggacgaaccucugguauaccaguugucccaccaggggcacggcuggauagccacguucggacaggauaaccgcugaaagcaucuaagcgggaaaccucuuccaagaccaggcuucucacccucuaggagggauaaggccccccgcagaccacgggauugauagaccagaccuggaagccuaguaauaggugcagggaacuggcacuaaccggccgaaaacuuac 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Structure of the 50S large ribosomal subunit from Mycobacterium smegmatis; 23S rRNA 5o60 B 118 3.18 RF00001 URS00000ACC0A_246196 28683309 0003735 0005840 246196 guuacggcgguccauagcggcagggaaacgcccggucccaucccgaacccggaagcuaagccugccagcgccgaugauacuacccauccggguggaaaaguaggacaccgccgaacac <<<.<<<<<<<.....<<<<<<<<.....<<<<<<.............>>>>..>>....>>>>>>.>>.<<.......<<<<<<....>>>>>>.......>>..>>>>>>>>>>.. (((.(((((((.....((((((((.....((((((...(.....)...))))..))....)))))).)).((.......((((((....)))))).......))..)))))))))).. Structure of the 50S large ribosomal subunit from Mycobacterium smegmatis; 5S rRNA 5o61 A 3119 3.31 RF02540,RF02541 URS0000BC467B_246196 28683309 0003735 0005840 246196 aaguguuuaagggcgcaugguggaugccuuggcacugggagccgaugaaggacguaggaggcugcgauaagccucggggagcugucaaccgagcguugauccgaggauguccgaauggggaaacccggcacgagugaugucgugucaccaggcgcugaauauauaggcgucuggggggaacgcggggaagugaaacaucucaguacccguaggaagagaaaacaaaaugugauuccgugaguaguggcgagcgaaagcggaggauggcuaaaccguaugcaugugauaccggguagggguugugugugcgggguugugggaccuaucuuuccggcucuaccuggcuggagggcagugagaaaauguugugguuagcggaaauggcuugggauggccugccguagacggugagagcccgguacgugaaaacccgacgucugucuugaugguguucccgaguagcagcgggcccguggaaucugcugugaaucugccgggaccacccgguaagccugaauacuucccagugaccgauagcggauuaguaccgugagggaauggugaaaaguaccccgggaggggagugaaagaguaccugaaaccgugcgcuuacaauccgucagagcccucgacgugucguggggugauggcgugccuuuugaagaaugagccugcgagucagggacaugucgcgagguuaacccgggugggguagccgcagcgaaagcgagucugaauagggcguauccacacaagagugugugguguagugguguguucuggacccgaagcggagugaucuacccauggccagggugaagcgcggguaagaccgcguggaggcccgaacccacuuagguugaagacugaggggaugagcuguggguaggggugaaaggccaaucaaacuccgugauagcugguucuccccgaaaugcauuuaggugcagcgucgcauguuucuugccggagguagagcuacuggauggccgaugggccccacaggguuacugacgucagccaaacuccgaaugccgguaaguccaagagugcggcagugagacggcgggggauaagcuccgugcgucgagagggaaacagcccagaucgccggcuaaggccccuaagcgugugcuaaguggaaaaggaugugcagucgcgaagacaaccaggagguuggcuuagaagcagccacccuugaaagagugcguaauagcucacuggucaagugauugugcgccgauaauguagcggggcucaagcacaccgccgaagccgcggcagccaacguguuggcuggguaggggagcguccugcauccggugaagccgccgagugaucgagugguggagggugugggagugagaaugcaggcaugaguagcgauuaggcaagugagaaccuugcccgccgaaagaccaaggguuccugggccaggccaguccgcccagggugagucgggaccuaaggcgaggccgacaggcguagucgauggacaacggguugauauucccguacccguguaugugcguccaugaugaaucagcgguacuaaccauccaaaaccaccgugaccgcaccuuucgggguguggcguugguggggcugcaugggaccuucguugguaguagucaagcgauggggugacgcaggaagguagccguaccggucagugguaauaccgggguaagccuguagggagucagauagguaaauccgucuggcauauauccugagaggugaugcauagccgagugaggcgaauucggugauccuaugcugccgagaaaagccucuagcgaggacauacacggcccguaccccaaaccaacacagguggucagguagagaauacuaaggcguacgagugaacuaugguuaaggaacucggcaaaaugcccccguaacuucgggagaagggggacccacauggcguguaagccuuuacggcccaagcgugaguggguggcacaaaccagugagaagcgacuguuuacuaaaaacacagguccgugcgaagucgcaagacgauguauacggacugacgccugcccggugcuggaagguuaagaggacccguuaacucccuuugggggugaagcggagaauuuaagccccaguaaacggcggugguaacuauaaccauccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaacgacuucucaacugucucaaccauagacucggcgaaauugcacuacgaguaaagaugcucguuacgcgcggcaggacgaaaagaccccgggaccuucacuacaacuugguauuggugcucgauacgguuuguguaggauaggugggagacugugaagcucacacgccaguguggguggagucguuguugaaauaccacucugaucguauugggccucuaaccucggaccguauauccgguucagggacagugccugguggguaguuuaacuggggcgguugccuccuaaaauguaacggaggcgcccaaagguucccucaaccuggacggcaaucagguguugaguguaagugcacaagggagcuugacugcgagacggacaugucgagcagggacgaaagucgggacuagugauccggcaccucugaguggaaggggugucgcucaacggauaaaagguaccccggggauaacaggcugaucuuccccaagaguccauaucgacgggaugguuuggcaccucgaugucggcucgucgcauccuggggcuggagcaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguuuagaacgucgugagacaguucggucucuauccgccgcgcgcgucagaagcuugaggaaaccugucccuaguacgagaggaccgggacggacgaaccucugguauaccaguugucccaccaggggcacggcuggauagccacguucggacaggauaaccgcugaaagcaucuaagcgggaaaccucuuccaagaccaggcuucucacccucuaggagggauaaggccccccgcagaccacgggauugauagaccagaccuggaagccuaguaauaggugcagggaacuggcacuaaccggccgaaaacuuac 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((((......((((((((((.....(((..(((((((((((((......((((((.[[.[[[.))).....((((((...(((]]]..]].)))......))))))...)))....(((....)))(((((((......))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))....((([...((((((((((........[[[[[[.....))))))))))....(.((((..(...(.(((((((]]]]]]))))))).(((((.......((((((.((((.(((...(.((((......)))))[[(...).(((.....]])))...)))...)))))))))))))))..)...)...))))]....(((((((...[.......)))))))....).(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((..(((((((((..)))).)))))..)))).<.(.(........).).((((((..(.(((.((((((((((..(((...(((....)))...)))...((....))..((((.....))))....(((((((....)))))))....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......A))))))))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))(((((((((.([.((((((((.....(((....(((.((((....(..(((....)))...)....)))).)))..)).).....))))))))....).]))))))).))..((((((((((......)))))).))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.((([.(((.........)))..))).....(]..((......)).).)))))...)))))))))).))...........]]].)....))))))))))...)))))))((((((((..))))))))....))))))(.((((((((((......((((((((....))).)))))...))))))))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]]((((((((((.(.....((((..((((((((......((((.((...((((((...((.((((......)))).))..).)))))...)).)))).....))))))))....)))).((...(((((...((((..(((..((((..(((((....{{....))))).((..(((....(((((((((((.((.....))))))))).....))))..[.)))...))...(((......))).....))))...)))...))))(..)....)))))..))..).)))))))))))))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((...((((....((((..)])))....))))..))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((....((((..((((((...))))))...))))....))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....))[[..(((((.....>]])))))..((((((((.(((.((......((((((((((..(((((.(((.(((((.((.((((((((((((..(..........((((...((......((.(((((....))))).))...)).............)))).)..)))))))))))).))...(((.((((((......)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.(.((((...((.......))...)))).)...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))..a.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..(((((...)))))....((((.((((.......)))).....(((.((((.(((....(((((....)))))...)))..))))..)))...))))....)))).. The complete structure of the Mycobacterium smegmatis 70S ribosome; 23S rRNA 5o61 B 118 3.31 RF00001 URS00000ACC0A_246196 28683309 0003735 0005840 246196 guuacggcgguccauagcggcagggaaacgcccggucccaucccgaacccggaagcuaagccugccagcgccgaugauacuacccauccggguggaaaaguaggacaccgccgaacac <<<.<<<<<<<.....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<.......<<<<<<....>>>>>>.......>>..>>>>>>>>>>.. (((.(((((((.....((((((((.....((((((...(.....)...))))..))....)))))).)).((.......((((((....)))))).......))..)))))))))).. The complete structure of the Mycobacterium smegmatis 70S ribosome; 5S rRNA 5o61 BA 1511 3.31 RF00177,RF01959,RF01960 URS00001AF2F7_246196 28683309 0003735 0005840 246196 uuuggagaguuugauccuggcucaggacgaacgcuggcggcgugcuuaacacaugcaagucgaacggaaaggcccuuucggggguacucgaguggcgaacgggugaguaacacgugggugaucugcccugcacuuugggauaagccugggaaacugggucuaauaccgaauacacccugcuggucgcauggccugguaggggaaagcuuuugcggugugggaugggcccgcggccuaucagcuuguugguggggugauggccuaccaaggcgacgacggguagccggccugagagggugaccggccacacugggacugagauacggcccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagcgacgccgcgugagggaugacggccuucggguuguaaaccucuuucagcacagacgaagcgcaagugacgguaugugcagaagaaggaccggccaacuacgugccagcagccgcgguaauacguaggguccgagcguuguccggaauuacugggcguaaagagcucguaggugguuugucgcguuguucgugaaaacucacagcuuaacugugggcgugcgggcgauacgggcagacuagaguacugcaggggagacuggaauuccugguguagcgguggaaugcgcagauaucaggaggaacaccgguggcgaaggcgggucucugggcaguaacugacgcugaggagcgaaagcguggggagcgaacaggauuagauacccugguaguccacgccguaaacgguggguacuagguguggguuuccuuccuugggauccgugccguagcuaacgcauuaaguaccccgccuggggaguacggccgcaaggcuaaaacucaaaggaauugacgggggcccgcacaagcggcggagcauguggauuaauucgaugcaacgcgaagaaccuuaccuggguuugacaugcacaggacgccggcagagaugucgguucccuuguggccugugugcagguggugcauggcugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuugucucauguugccagcacguuaugguggggacucgugagagacugccggggucaacucggaggaagguggggaugacgucaagucaucaugccccuuauguccagggcuucacacaugcuacaauggccgguacaaagggcugcgaugccgugagguggagcgaauccuuucaaagccggucucaguucggaucggggucugcaacucgaccccgugaagucggagucgcuaguaaucgcagaucagcaacgcugcggugaauacguucccgggccuuguacacaccgcccgucacgucaugaaagucgguaacacccgaagccgguggccuaacccuuguggagggagccgucgaaggugggaucggcgauugggacgaagucguaacaagguagccguaccggaaggugcggcuggauc ......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<..<<<<<<<....>>>>>.>>>..>>>>>......<<........<<<<<<<..<<...<<<<<<<<<<<<.....<<<<<......>>>>>......>>>>.....<<<<<<<<<<<<..>>>>>.>>>>>>>....<<....>>>>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<......>.......>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<.....<<<<<<<.....>>>>>>>...>>>>>>>..>>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<<..<<<......>>>.....>>>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<.......>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>.<<.....>>.>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<<..<<<......>>>>>.....>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>......>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<..<<<<....<.<<<<..<<<..<<.....>>.>>>.>>>>.>...>>>>..>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... ......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((....))))).)))..)))))......(((.......(((((((..((...((((((((((((.....((((((....))))))......)))).....(((((((((((....)))).)))))))....((....))))))))))..))))))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(..((....))..)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((.....(((((((.....)))))))...))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((.(.......).))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((((((....))))))).((.....))).))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((.(...((..(((......)))))....).)))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((...(((....)))...))....)))......)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((..((((....(.((((..(((..(((..).)).))).)))).)...))))..))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... The complete structure of the Mycobacterium smegmatis 70S ribosome; 16S rRNA 5o61 BW 76 3.31 RF00005 URS00005AA258_246196 28683309 0030533 0006412 246196 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).(((((.......))))).....(((((..]....)))))))))))).... The complete structure of the Mycobacterium smegmatis 70S ribosome; P/P-site Phe-tRNA(Phe) 5o9z Y 46 4.5 28781166 9606 ccuccgaacgguaagagccuagcauguugaugucauacuuauccug .............................................. .............................................. Cryo-EM structure of a pre-catalytic human spliceosome primed for activation (B complex); MINX pre-mRNA 5o9z 2 100 4.5 RF00004 URS00003EE995_9606 28781166 0045131 0000348 0005686 9606 cgcuucucggccguguaguaucuguucuggauuuuuggagcagggagauggauccacuccacgcaucgaccugguauugcaguaccuccaggaacggugc ...........................................<<<<.<<<..>>>>>>>..<<<<<<.<<<<<.............>>>>>..>>>>>> ...........................................((((.(((())))))))..(((.((.(((((.............)))))..)).))) Cryo-EM structure of a pre-catalytic human spliceosome primed for activation (B complex); Human gene for small nuclear RNA U2 (snRNA U2) 5o9z 4 137 4.5 RF00015 URS0000200C70_9606 28781166 0017070 0000244,0000353 0005687,0046540 9606 agcuuugcgcaguggcaguaucguagccaaugagguuuauccgaggcgcgauuauugcuaauuacuuuucccaauaccccgccgugacgacuugcaauauagucggcauuggcaauuuuugacagucucgagacugg ...................<<<<<.<<<.....<<.....>>..>>>>>>>>............................<<<<<<.<<<<<........>>>>>.>>>.>>>.........<<<<<<..>>>>>>. ...................((((..(((.....((.....))..))).))))............................(((.((.(((((........))))).))..))).........((((((())))))). Cryo-EM structure of a pre-catalytic human spliceosome primed for activation (B complex); Homo sapiens U4A snRNA 5o9z 5 114 4.5 RF00020 URS0000118C49_9606 28781166 0000244,0000353 0005682,0046540 9606 acucugguuucucuucagaucgcauaaaucuuucgccuuuuacuaaagauuuccguggagaggaacaacucugagucuuaacccaauuuuuugagccuugccuuggcaaggcua .<<<...<<<<<<<<<<........<<<<<<<<.<.......>.>>>>>>>>...>>>>>>>>>>.......>>>..................<<<<<<<<....>>>>>>>>. .(((...((.((((.((........((((((((...........))))))))...)).)))).)).......)))..................((((((((....)))))))). Cryo-EM structure of a pre-catalytic human spliceosome primed for activation (B complex); Homo sapiens U5 A small nuclear RNA 5o9z 6 90 4.5 RF00026 URS000035C796_9606 28781166 0030621 0000244,0000353 0005688,0046540 9606 gugcucgcuucggcagcacauauacuaaaauuggaacgauacagagaagauuagcauggccccugcgcaaggaugacauucgugaagcgu <<<<<.<<....>>>>>>>....................................................................... (((((.((....)))))))....................................................................... Cryo-EM structure of a pre-catalytic human spliceosome primed for activation (B complex); Homo sapiens RNA, U6 small nuclear 1 (RNU6-1), small nuclear RNA 5oa3 1 75 4.2 RF00005 URS00002CB170_4932 28732596 0030533 0006412 4932 agcgccguggcgcaguggaagcgcgcagggcucauaacccugauguccucggaucgaaaccgagcggcgcuacca <<<<<<<..<<<<.......>>>><<<<<<.......>>>>>.>...<<<<<.......>>>>>>>>>>>>.... (((((((..((((....[..)))).(((((.......))))).....(((((..]....)))))))))))).... Human 40S-eIF2D-re-initiation complex; initiator Met-tRNA-i 5oa3 2 1661 4.2 RF01960,RF01959,RF00177 URS000046EEE1_9606 28732596 0003735 0005840 9606 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucguacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgccggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucucucucggccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgaccggucggcguaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcguguccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccgggccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<....<<....<<<<<.........<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<<<....>>>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<..>>>>>>>.>>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....<<<<<<<<<.<<<....>>>..>>>>>>.>>>......<<..<...........>..>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<...<<.<<<..>>>>>...<<<<<<.<.......<<...<.......>.<<<<.>>>>...>>......>.>>>..>>>........<.<<.<<<<<<<...............>>>>>>>.>>.>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<......>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<<<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<..>>>.>>>>>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>...>.>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<.<<<........<.<<<.<<<<....>>>>.>>>....>.........>>>.>>............<<<<<..........>>>>>...........>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<...<<<<<<<<<.<<<..<<<<.<<...<<<<<.<<<<<<<..>>>>>>>...>>>>>...>>.>>>>..>>>.>>>>>>>>>..>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..((....(((......([...((.....((.(((.....))).))......))......)..((((...((((((....))))))...))))((..(((((...(......)..)))))......)).(]((((.(((()))))))))...)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).).....(((((((((.(((....)))..)))))).)))....(.((..(...........)..))......)..((((([[....(.((((.....((..]])).......))))))))))..)))))).)))..[......(.([[...(.(.((...(((......((.(((())))))...((((((.(.......((..((.......)).(((.)))....))......).)))..)))........(.((.(((((((...............))))))).)).).........(((.(((..(...((((..(((.((((((((...((........))......)))))))).))).......((....))...))))..)..)))..))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.((((......)))))))))).)..)))...((..]]))...))...].))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....((((((....(..((.(((........))).))....)))))))...((.(((.....((((((....(((.(((((....)))..(.((......)))...)).)))....(((...(...((((..((.((((((((()))).))))).))..))))..).....(((((.....)))))........)))....))).))).......))))).....).)))))...)).)))).))).(...((.(((........(.(((.((((....)))).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..((((.((...(((((((((((((()))))))).).)))))...)).))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}........ Human 40S-eIF2D-re-initiation complex; 18S ribosomal RNA 5oa3 3 186 4.2 RF00061 URS0002335999_11103 28732596 0043022 11103 cuccccugaggacccccccucccgggagagccauaguggucugcggaaccggugaguacaccggaauugcgagauuugggcgugcccccgcaagacugcuagccgaguaguguugggucgcgaaaggccuugugguacugccugauagggugcuugcgagugccccgggaggucucguagaccaug ....<<<.>>>......<<<<<<<<<<<.<<<<<<<<<<<<<<<<<..<<<<<<....>>>>>><<<<....>>>>.<<<<..>>>>>>>>.>>>>>>>>><<<.....<<........>>....>>>....>>>>.>><<<<....>>>><<..(((((.>>>>>>>>>>>.)))))........ ....(((.)))......(((((((((((.((((((((((.((((((..((((((....))))))((((.().)))).((((..)))))))).)).))))))(((.....((........))....)))(..)))))[))((((..].))))((..[[[[[.))))))))))).]]]]]........ Human 40S-eIF2D-re-initiation complex; IRES mRNA 5obm 1 3100 3.4 RF02540,RF02543 URS000061F377_559292 29208708 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggaaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucgggacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>...{.....<<....>>..<<<<<......<<.....>>.....>>>>>..[[[...........<<.<<<<<<...>>>>>>.>>.............<<<<<<<.<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]....}.............................<<....>>...............<<<......>>>..................................<<<<<.<<<<<<.....<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<......>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>(><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>).<<<<.<<<<<.....>>>>>.>>>>....<<<..[...>>>...<<<<<<<..<<<<(((.....<<<<<<......<.....]....<<<.<<<<<<<<<<.......<<<<<..>>>>>...>>>>>>>>>>>>>..........))).>....>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>>..<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<...............>>>>><<.<<<<<<<<<<.....>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<..<<<<<<<<..<<<<<<<<<...>>>>>>>>>...<<<<<.....<<<<..<<<<........>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>...>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<....<<<......>>>....>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((.(((...))).)).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((......((((..(...).)))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...(.((((.....)))).).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((..)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........(..................)....))....))...(((((........)))))]]((((..(((.(((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....)))...))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((((.....))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..((.((((.(...).)))).))....((((.....((((..(((..........)))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......(((..(.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).)..)))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((..((..)..)..))..)))))...)))....)))).)))))).))))).. Crystal structure of Gentamicin bound to the yeast 80S ribosome; 25S ribosomal RNA 5obm 3 121 3.4 RF00001 URS000055688D_559292 29208708 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of Gentamicin bound to the yeast 80S ribosome; 5S Ribosomal RNA 5obm 4 156 3.4 RF00002 URS00001BF64E_559292 29208708 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaaccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]..........).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of Gentamicin bound to the yeast 80S ribosome; 5.8S ribosomal RNA 5obm 2 1712 3.4 RF01960,RF01959,RF00177 URS00005F2C2D_559292 29208708 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguucacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugccagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucau ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[...........<.....<<.<<.......>>.>>......>.........<<<<<..<......>..>>>>>[...((((((......<<<<<<<<<<<....>>>..............)))))).....]...<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<..<....>..>>.>>>......<<<.<...........>>.>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.[[....<<<<<<.<<<<<....<..>....>>>>>.>>>>>>....<<<<<<...>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[...((((((((....>>>>>>>>.))))))))..]].....]]....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<......>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<.......<<........>>..........<<<<<......<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>.......>>>>>....>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>......<....<<<<<<..........>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<......<<<<......>>>>......>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>....... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((...........((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[[[[[[[((......)).....(......).)))))).)...).(.((((.....(....)...)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....((..(.(((()))).)...))......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.((((......()......)))).))))))....((((((...))))))...((.((.((.......((..((.......)).(((.....)))....))......)).))...)).........(....(.((.(((....]]]]]]]].))).)).)...).....))...(((..((.((...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)).))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.((..........))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((.(((..........))).))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...((.((....)).))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>...... Crystal structure of Gentamicin bound to the yeast 80S ribosome; 18S ribosomal RNA 5obm 5 3134 3.4 RF02540,RF02543 URS000061F377_559292 29208708 0003735 0005840 559292 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........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<.<<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<......>>>..................................<<<<<.<<<<<<...........<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>(><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<..>>>>>>.>>>>....>>>..>>.>.....>>>>>...<<<<.<<<<.........>>>>.>>>>.....>>>>>.>>>>>>>>.>>).<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<......<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>....>>>>>>.>>>>..>>>>>>><<<<<<<<<.....>>>>>>>>>....>>>>>>..<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<.>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>...<...<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>...>......>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<...............>>>>><<.<<<<<.<<<<<..>>>>>...>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<..<<<.....<<<<....>>>>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<..>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.....................<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((.(((((((...({((((......)))))[[(...).(((....}]])))....)))))))...))))))))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((...........(((((((((((((((((((((((.......(((((((......((((.(....).)))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.(((....(.((((..)))).)..))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.......(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.....)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((..(((((((...((.....)).))))))....[[(((.((...((....(((....)))........(.(.....).)....))....))...(((((........)))))]]((((..(((((((...((((....)))...(.<.((((((...((((.(((((((.((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......)))))))))))...))))))).))))(...)....))))))...))....))))..))).)))).))).))).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((..((..(..)..))....)))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...(......((((....))))......).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(.(((((((..))))))).)....((((.....((((..(((((......)))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.............))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Crystal structure of Gentamicin bound to the yeast 80S ribosome; 25S ribosomal RNA 5obm 7 121 3.4 RF00001 URS000055688D_559292 29208708 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of Gentamicin bound to the yeast 80S ribosome; 5S Ribosomal RNA 5obm 8 158 3.4 RF00002 URS00001BF64E_559292 29208708 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of Gentamicin bound to the yeast 80S ribosome; 5.8S ribosomal RNA 5obm 6 1739 3.4 RF01960,RF01959,RF00177 URS00005F2C2D_559292 29208708 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguucccuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacaguuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccgguacuggauuuccaacggggccuuuccuucuggcuaacuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.{.[[[[>>>>><<<<.<<<<<<...<.<...<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<..<<..<<....<<<..............<.....<<.<<.......>>.>>......>.........<<<<<..<<....>>..>>>>>....<<<<<<......(((((((....<..>.................>>>>>>.........<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>..>>>..>....>.>.....<<<<<<<..>>>>.>>.>.....<<..<...........>..>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>>>>>.........<<<[[.....<.<<...<<<.<<....<<<<<<.<<<..<<<<..>>>>......>>>.>>>>>>....<<<<<<............>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........<<<..<<<<<<<<.....))))))).>>>>>>>>.>>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>......<<<....>>>..>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<<.....>.>>>>>>>>>>>..>>>...<<..]]>>...>>.....>>>.>>>.<<<......<<<......>>>....>>>..]]]].}<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<......<<<<<<<.<<<<.....>>>>.>>>>>>>......>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..............(.....((.(((.....))).))......).........(((((..((....))..)))))(.(.((((((......[[[[[[[................(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((....(((.}...)))..)))).)....).).....(.(((((..)))).).)......(.(..............)..).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.((...((.(...))).......)).))))))....((((((............))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(((..(.((.(((.....]]]]]]].))).)).).))).....))...(((..((.((...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)).))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((........((.(((........))).))......)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...(((((((.((((.....)))).)))))))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>........ Crystal structure of Gentamicin bound to the yeast 80S ribosome; 18S ribosomal RNA 5oc6 B 11 3.2 URS000080E0A2_32630 30605527 32630 cgaacuucgcg ........... ........... Crystal structure of human tRNA-dihydrouridine(20) synthase dsRBD in complex with a 22 nucleotide dsRNA; RNA 5oc6 C 11 3.2 URS000080E0A2_32630 30605527 32630 cgaacuucgcg ........... ........... Crystal structure of human tRNA-dihydrouridine(20) synthase dsRBD in complex with a 22 nucleotide dsRNA; RNA 5on6 1 3149 3.1 RF02540,RF02543 URS000061F377_559292 29429877 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu .........................<<<<<.....<......>......>>>>>...........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<<.<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<......<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>>..<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<...............>>>>><<.<<<<<<<<<<......>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<...<<.....<<<<....>>>>.....>>.>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<.....>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>........<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>.....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<...<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>...>>>>..<<<<<.....................<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((......((((........)))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...(..(((.....)))..).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((..((...((.........))...))......(...(........).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........(..................)....))....))...(((((........)))))]]((((.((((.(.(...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....).)...)))))))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((((.(...)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.........)))))))....((((.....((((..((((........))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......(..(.(.((((((...((.......))...))))))...))...)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......((((...(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).)))...))))..(((((.(..(.......)..).....(((((((((.(((....((((.(..(...((..)..)...)..)))))...)))....)))).)))))..))))).. Crystal structure of haemanthamine bound to the 80S ribosome; 25S ribosomal RNA 5on6 3 121 3.1 RF00001 URS000055688D_559292 29429877 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of haemanthamine bound to the 80S ribosome; 5S ribosomal RNA 5on6 4 158 3.1 RF00002 URS00001BF64E_559292 29429877 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of haemanthamine bound to the 80S ribosome; 5.8S ribosomal RNA 5on6 6 1783 3.1 RF01960,RF01959,RF00177 URS00005F2C2D_559292 29429877 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccucuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucacuggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[...............<.....<<.<<.......>>.>>......>.........<<<<<..<<....>>..>>>>>[...((((((......<<<<<<<<<<<<..>>>>....<........>)))))).....]...<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<<<<..............>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.{{....<<<<<<.<<<..<<<<...>>>>......>>>.>>>>>>....<<<<<<....<<..<<<<.......>>>>..>>....>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[[..((((((((....>>>>>>>>.)))))))).]]].....}}....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<<.....>.>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<<<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>...>.>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<.<<<..<........>....>>>.>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((...............(.....((.(((.....))).))......).........(((((..((....))..)))))(.(.((((((......[[[[[[[..((....))......(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(((((.(................).)).)))........(.(...........))............((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((.(((((...))))....).))).))))))....((((((....((..(((.........)))..))....))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(((..(.((((((.....]]]]]]].)))))).).))).....))...(((..((..(...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)..))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((........((.(((........))).))......)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...(((((((.((..................)).)))))))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>........ Crystal structure of haemanthamine bound to the 80S ribosome; 18S ribosomal RNA 5on6 AR 3149 3.1 RF02540,RF02543 URS000061F377_559292 29429877 0003735 0005840 559292 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........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..<<<..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<<.<<<<<.<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>.>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<<.....<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<......>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>(><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<.......>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.........>>>>.>>>>.....>>>>>.>>>>>>>>.>>).<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<......<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>....>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..[[[..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<<....>>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<....<....>.....>>>>><<.<<<<<<<<<<......>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>.<.<<..<<<..<<<<<<.<..<<<.....<<<<....>>>>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>.>..>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<..<<<<<<<<.......>>>>>>>>...<<<<<.....<<<<..<<............>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))......<<<<<<<..<<<<.))))))>>>>>>>>>>>.........>>>>..>>>>>>.......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>........<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>.....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<.]]]..>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((.(((((.(((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..).))).))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((......((((........)))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...(..(((.....)))..).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.......(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........(..................)....))....))...(((((........)))))]]((((.((((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....))))..)))))))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((((.(...)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.........)))))))....((((.....((((..((............))...........>...(((((......)))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.............))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(((..(..)....)))..)))))...)))....)))).)))))).))))).. Crystal structure of haemanthamine bound to the 80S ribosome; 25S ribosomal RNA 5on6 AS 121 3.1 RF00001 URS000055688D_559292 29429877 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of haemanthamine bound to the 80S ribosome; 5S ribosomal RNA 5on6 AT 158 3.1 RF00002 URS00001BF64E_559292 29429877 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of haemanthamine bound to the 80S ribosome; 5.8S ribosomal RNA 5on6 A 1781 3.1 RF01960,RF01959,RF00177 URS00005F2C2D_559292 29429877 0003735 0005840 559292 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...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[..................<.....<<.<<<.....>>>.>>......>.........<<<<<..<......>..>>>>>....((((((......<<<<<<<<<<......>>..............)))))).........<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<.<<....<..........>....>>..>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.[[....<<<<<<.<<<<<....<..>....>>>>>.>>>>>>....<<<<<<...............................>>>>>>....<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>..........[[...((((((((....>>>>>>>>.))))))))..]].....]]....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<.......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<..<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>........>>>>....>>>.>>>.....>>>>>>>>....>.>>>>>....>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<......<<<<<<<.<<...<.........>....>>.>>>>>>>......>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>....... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[[[[[[[(((....))).....(......).)))))).)...).(.((((..((.(....))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(...(.(................).)....)......(.(.(...........))..).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((((.....().....))))).)))))).....(((((...............................)))))....(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(......((.(((....]]]]]]]].))).)).....).....))...(((..((..(...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)..))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..((((..((((((....))))))....))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...(.((....(....................)....).))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>...... Crystal structure of haemanthamine bound to the 80S ribosome; 18S ribosomal RNA 5oql 1 1350 3.2 RF01960,RF01959,RF00177 URS0000BC4681_759272 28967883 0003735 0005840 759272 ggggggauguccgggucgcccugggcaccucuccgcggcagcgcaagccguuucauacgucgccgcaaucgcgaggggcuccaagcggucgccggcgagcaccaccccagccccgcgccgcccccagcgcaccgcgcgcaggggggccggcgcggcaucugggaagacuccuaaggcgcaagggaauaccccgugcgccggggguugggcucugugggugcuuggccgcuggccagaccuacuucaaagccaccggggguaccuaccgguugucucggucgggccuccucuuggggcgccuaggcggugucuucgggucgcgugcagccucccguccucgccugccgacagcgcucuggggaauucaggaggggaaagcagaugugccccgcggcgagacuggcgccggacgagcugcuggggcacgcggguacgcuagccgcacgauaguuaccugguugauucuuagucauaugcuugucucaaagccaugcgucuaaguauaagcaauuacagcgaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguauggauaaccgugguaauucuagagcuaauacaugcguauuuauuagggugauucauaauaacuucucgaaucgcacggccuugcgccggcgaugguucauucaaauuucugcccuaucaacuuucgacggcuggguauuggccagccguggugacaacggguaagagaggagccugagaaacggcuacuacauccaaggaagggcaggcgccaaauuacccaaucccgacacggggagguagugacaauaaauacugauacagggcuccgggucuuguaauuggaaugaguacaauuuaaaucccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauucccuccaauagcguauauugcucguaguugaaccugauuaauagggacagucgggggcgucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacaacugcgaaagcauucgccaaggauguuuucauuaaucaggaacgauuagggaucggacggcguuuauuuuugacccguucggcaccuuacgauaaaucaaaauguuugggaguauggucgcaugacggaagggcaccaccagggguggagccugcgcgcgcgcuacacugacagagccagcgaguacucccuuggccgagaggcccggguaaacucugucgugcugaggaaucccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuacuaccgauagaggaagua <<.<<<.<<<<<<<<....>>>>>>>>>>>.>.>.<<<<.<..>..>>>>.........<<<<<<<.<<<<<..<<<<>>>>..>>>>>.>>.>>>>>....<..<<<<<..<<<<<<<<<<<<<.<<<<.....>>>>..>>>>>.>>>>>>>>...>>>>>..>........<<<<<<.<<<.....>>>.>>>>>>.........................<<<...>>>.....................<<<<<..<<<<<<<<.....>>>>>.>>>>>>>>.....<<<<<<...<<<<<<<....<<<<..<<.....>>..>>>>....>>>>.>>>....>>>>>>...........................<<<<.<<<<<<<..<.<<<<..>>>>.>..>>>>>.>>.>>>><<<<.<.....>.>>>>.........................<..<<<<<<...<.<<..<<<<.<<<<<....<<....<<.......>>...>>.>>......<<<.......<<<..<<..<<....<<<.......<.<..<..<<<.....>>>..>.....>>....<...<<<<<<.<......>.>>>>>>.....>...<<<<.<<<<.....>>>>>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...>>><<.<<<..........>>>.>>.<.<<<..>>>.>.>>>>>>........<<<...<<<<<...>>>>.>>>>..>>...>.>....<<<<<<<<<<<<<...>>>>>>>>.>>>>>.....<<..<...........>..>>.........<<<<<<.......<<<....>>>................>>>>>>..>>>>>>.>.<.<<...<<<.<<.....>>.....<<<<<.<<...<<<<..<<<.<<<<<<.....<<<......>>>........>>>>>>.>>>.......<<....>>...>>>>..>>.>>>.>>....>>>...>>.>..<..<<..<<<<<<<<.<<<.......>>>>>>>>>>>..>>.....<....>....>....................<<<<<<<<<<<<<..<<.<<<<<<..<<<.<<<..>>>.>>>.....<<<<<<<..............<<.<<<<....>>>>.>>.....>>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>............>>>>>>.<<<<.<<......>>.>>>> (((.((.((.((.((....)).)).)))).).)).((((.(())..)))).........(((((((.(((((..(((())))..))))).)).)))))..(.(..(((((..((((((((((.((.((((.....))))..).))).))))))))...)))))..)..).....((((((.(((.....))).)))))).........................((([..)))....]................(((((..((((((((.....))))).)))))))).....((((((...(((((((....((((..((.....))..))))....)))).)))....))))))...........................(((.((((((((..(.((((..)))).)..))))).).)))))((((.(.....).))))........................(((.((((((...(.(...((((.(((((....((....((.......))...))[))......(((.......(((..((..((....(((.......(....(..(((.....)))..)......)....(.(.((((((.(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....(((.((((.......)))).))))))......)))...)))((.((.(.........))).)).(.((....)).).))))))......(.(((...((((.]...))).))))).)....).)....((((((((((((((.))))))))).)))))...(.(((.(...........)).))......)..(((((((......(((....)))...............)))))))..)))))))))(.((...((..((.....))...(((((((.((...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)).))).)))..).))...)).).((.(.((.(((.((((.(((.......))))))).)))..)))...((....))...))...................((((((.((((((..((.((((((..(((..((()))..))).(...(((((((..............((.((((....)))).)).....))))))).......)..))))))....((((((((.......))))))))......))...)))))).............)))))).((((.((..()..)).)))) Cryo-EM structure of the 90S pre-ribosome from Chaetomium thermophilum; 35S rRNA 5oql 2 230 3.2 RF01846,RF01848 URS0000BC465F_759272 28967883 0006396 0005730 759272 agcgacaauacuucagagaaucauuucuauaguaguuguccucucuuguguuuccuaaaggagccacagaucccacccggguugaugaacgagauccucggcgccagugagguccauuuacucucgcucuaccugcaaagguggcggucgcgugccucgucucgcggcuguauagagaguggcgaugaucuguaccccgcggggugggugucgauggaagucugaccggc ............................................................................<<<<..............<<<<<<<<<<.<<............<<<<<<...<<<<<<....>>>>>><<<<<<<<.<......>.>>>>>>>>....>>>>>>.........>>.<<<<<<..>>>>>>.>>>>>>>.>>>.......>>>>. ............................................................................((((......(.......((((((((.((((...(.........(((((...(.((((....)))).)(.((((((.(......).)))))).)....)))))...)......))..(((((()))))).)).))))).)))...)...)))). Cryo-EM structure of the 90S pre-ribosome from Chaetomium thermophilum; U3 snoRNA 5or0 A 11 NA URS0000BC466C_9606 29133793 9606 auacuuaccug ........... ........... NMR derived model of the 5'-splice site of SMN2 in complex with the 5'-end of U1 snRNA; RNA (5'-R(P*AP*UP*AP*CP*(PSU)P*(PSU)P*AP*CP*CP*UP*G)-3') 5or0 B 11 NA URS0000BC4661_9606 29133793 9606 ggaguaagucu ........... ........... NMR derived model of the 5'-splice site of SMN2 in complex with the 5'-end of U1 snRNA; RNA (5'-R(P*GP*GP*AP*GP*UP*AP*AP*GP*UP*CP*U)-3') 5ot7 1 1507 3.8 RF00177,RF01959,RF01960 URS000080DDC6_300852 29408956 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggauca ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<...<..<<<.<<<..<<<..<<.<<<<<...<.......>...>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<...<<<<<<<....>>>>>>.>...>>>>>....<<<<...<<<....>>>...>>>>...<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<...<<<<<<<.......>>>>>>>.>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>.....<<.<<<....<<<<....>>>>..>>>>>.>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<.<<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<......<<<<<....<<........>>.......>>>>>.............<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<..<<<....<<<<....<.......<<........>>...........<.<<<.................................................................<<<..<<<<<<.<.....<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>......<<<.<<<.<.....<....<.......>..>......>.>>>.....<<<........>>>........>>.>.....>...>>>...>>>>>>.......>>>..>....>.....>>>>.....<<..........<<...<<..<.<.......>.>.>>.....>>..........>>...............<.............>...............>>>.....<.<<<<<..........>>>>>.>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ....(((...[.[[[...))).((((.(((((..(((((((((....(((.(((..(((..((.((((((.)............))))).)))))......(((......((((((((..((...(((((((.(((((...(.(((((....)))))..)...)))))....((((................))))...(((.....))).)))))))..))))))))))(((....(((...(((((((.......)))))).))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((.......(((....)))......))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[.....((((....((.(((((((.((((((..(.......((((((.....)))))).....)..))))..)))))))))..((((((((.....(((((((......(.((.......................)).)......).......((....)).))))))....)))).)))..)))....))))(.......((...((...((((.........))))...)))).....)....{...((((((..((((.(.(((...))).).))))...((..]])).....)))))).))).(((......((((....))))....)))...]]].](((((.(((((((..(..((......((......(......(..........)..[........(.(.....(...............(............)...(............)..........)..(.(.(...((((((.(....(((((((((....)))...(((......)))...)))))).......((..(..................................)......((..........))........)).......).).)))...)).).))........).)....).......))......((...............((..(.((....).))..)).................))......(......(.(.............).).....)........)).....(.(((((.....]....)))).))......)....)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((.(((((....))))).)))}..... Elongation factor G-ribosome complex captures in the absence of inhibitors.; 16S Ribosomal RNA 5ot7 2 76 3.8 RF00005 URS00005AA258_562 29408956 0030533 0006412 562 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<...<<<..........>>>..<<..<.....>..>>......<<<<<.......>>>>>.>>>>>>.... (.((.......(...........)....(............)......(((((.......)))))...).)).... Elongation factor G-ribosome complex captures in the absence of inhibitors.; tRNA-Phe 5ot7 3 10 3.8 29408956 562 gugagguuuu .......... .......... Elongation factor G-ribosome complex captures in the absence of inhibitors.; mRNA 5ot7 4 2901 3.8 RF02540,RF02541,RF00002 URS0000CBFF3A_300852 29408956 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgggccgcacgcggcccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgcggcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccuguaaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu .<.......<<<<<<<<<<<....{[[..[[<<<<<<[[<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<....>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...(((....<<<<<<<.......>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>.]]...............<<....>>....]].........<<<<....>>>>.............}....>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>......<............>.......>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<.<<.........>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<.<.........<<<..<<<..<<...........>>..>>>.........<<......>>....>>>.....>.>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..((((...>>>>>><<<...<<<<<<<<<<.<<<<<.<<.....>>>>>>>.>.....>>>>>>>>>..>>>....<<<<....>>>>......>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<..<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>..<<<<.........>>>>.........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.........<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<....<<.............<<<.....<............<<<....>>>.........>...............>>>....>>...>.>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))........<<<<<<.((..>>>>..))>>>>>>..............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))))>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<.......>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>.....>. .(.......((((((((((.....(((..(((((((.((((......((((((.[[..[[.))).....((((((...(.(]]..]].).)......))))))...)))....(((....)))((((((((....)))))))).((((((....)))))).))...(.((((.....(...[..)......))))..).........((....))...(((((.....((.]...))....)))))...((([...(((.(((.......))).)))....(.(((((((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......))..))))).))...............((....))....))......(..((((....))))............)).....)))))))))).......(.(((((((((....))))))))).).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...........................)))))))))))))..((.(...((((((.....((((((((((.(((....((((((......))))))....[)))....((..((((........)))).).)..).))))))))).(.((.......))...)..))))))......).))..((((((....((((......))))(((((((((.(...(((((((((...(((...(((.((((...((...............))...)))).)))..)).)...)))))))))..)..))))))).))..((.((((..(......)..)))).)).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((((.((.....{.((((...((..((.(........)))..))..........((......))....))).)..)).))))))).))..........]]].)....))))))))))...)))))))(.((((((.....)))))).)....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((.([((((((...((.....)).)))))))...[[((((.((...((....(((....)))....))...))...(((((........)))))]](((((((((((((...(((.....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((..((((.((.....))))))..).....)))))))))..)))(....(((....)))......))))))...)))..)))))(..)......)))...))...))))))))))))))).])).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((...(..(((((((..(((...((...(((((....)))))...))...))))))))..)).)..(((...........))).........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)..{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((....(....(......[..((..(....(........(....(.....)......)..)............]..).)))....)...).)))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........])))))).[((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((......)))..)))).(((....))).))]]].]......((((((.((..]]]]..))))))))..............))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....)...)))))))))))[...(((((((...(.((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).).))..]....)))))))...................(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...)))).....). Elongation factor G-ribosome complex captures in the absence of inhibitors.; 23S Ribosomal RNA 5ot7 5 119 3.8 RF00001 URS000080DE2B_300852 29408956 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>> .((((((((((......(((.((....(((((((...(.....)...))))..)))...)).)))...(((.......((.(((((....))))).)).......))).)))))))))) Elongation factor G-ribosome complex captures in the absence of inhibitors.; 5S Ribosomal RNA 5t16 G 34 2.783 URS00021ED9BD_32630 28111020,24703949 32630 gcnaugucaugucaugaguccauggcauggcaug ..<<<<<<<<<<<<<<....>>>>>>>>>>>>>> ..((((((((((((((....)))))))))))))) Crystal structure of yeast RNase III (Rnt1p) complexed with a non-hydrolyzable RNA substrate analog; RNA substrate analog 5t16 H 34 2.783 URS00021ED9BD_32630 28111020,24703949 32630 gcnaugucaugucaugaguccauggcauggcaug ..<<<<<<<<<<<<<<....>>>>>>>>>>>>>> ..((((((((((((((....)))))))))))))) Crystal structure of yeast RNase III (Rnt1p) complexed with a non-hydrolyzable RNA substrate analog; RNA substrate analog 5t16 O 34 2.783 URS00021ED9BD_32630 28111020,24703949 32630 gcnaugucaugucaugaguccauggcauggcaug ..<<<<<<<<<<<<<<....>>>>>>>>>>>>>> ..((((((((((((((....)))))))))))))) Crystal structure of yeast RNase III (Rnt1p) complexed with a non-hydrolyzable RNA substrate analog; RNA substrate analog 5t16 P 34 2.783 URS00021ED9BD_32630 28111020,24703949 32630 gcnaugucaugucaugaguccauggcauggcaug ..<<<<<<<<<<<<<<....>>>>>>>>>>>>>> ..((((((((((((((....)))))))))))))) Crystal structure of yeast RNase III (Rnt1p) complexed with a non-hydrolyzable RNA substrate analog; RNA substrate analog 5t2a A 1603 2.9 RF02543,RF02540 URS0000B21DD8_5661 27752045 0003735 0005840 5661 agaccugaguguggcaggacuacccgccgaacuuaagcauauuacucagcggaggaaaagaaaacaaccgugauucucucagugagcggcgagcgaagagggaacgaacucguugccgaaucgggucuuacaaggccuugaguuguggcacaaauaucugguuggugcaggaguggcgaaauucaagcgcaaagcaaacccguugcugaauacaacccuucaugugaguauugagccaaagaagguguuagcccauugagccauaaaccugagcgccucaugaagcgaguagcacuguuugggaaugcagugucaaguuggcagguauuugucugccaaaguuaaauacagaguaggaagaccgauagcgaacaaguagcgugagcgaaaguuugaaaagcacuuuggaaagagagugaaauagaaccugaagucgugacaaagacaauggaaguaccuccauuucaacggccagaaccagcccuacugcauuauccugucgggggucaaaauccggcgggcaaaagugcaagaauuuugggucuuggugaaaugagcggaguauuugagcugugcacggccgcacgcacugguuucuucuccgugaugcuccauguuggcgaugaaauggggugcccccacccgucuugaaacacggaccaaggagucaaacagacgcgcaagggaggagauaugguugccaguacuucucucguacugaaagggagaugcaauaugcaucuguggugugcacacgucauuugcccaacaccgaccggcccuggguugcguuggagugugccuguuuggacccgaaagguggugaacuaugccugaacaaggugaagcccggggaaacccagguggaggccuguagcgaugcugacgugcaaaucgcucguaugauuuggguaucggagcgaaagacucaucgaaccaccuaguagcugguucacaucgaaguuucccucaggauagcuggugcuaguagaaguauugugcgguaaagcaaaugauuagagggaccuauucucaaacuuuaaaugugcaaacaaaccgugccuuagccaacugcaaggccggaaagaaaagaauuagaggcaccaagugggccuucuucgguaagcggagcaggcgaugcggaaugaaccgcuuagggauauguggcgucaaaacuuaugggcucauucucgauacgugaaaaggguguugguggauaaauccaccggccccgaaaauggaugacgcuuaagcccaauuagugguugcccauuauuccuuugguaagggcggaaacaaacggagaaaguguagcccuuccgauguagauguggccuggagguuaggacgaagcuuauggcgugagccuaagauggaccggccucuagugcagaucuugguuggcguagcaaagaucuaacggagauauacaacaugcaacguuggauacuggagcggggaaggauuucgugccaacggcacucguacacgaguuguucggaaacugagcacaacguuauaucguuuuguuaggaaagugaagguacugaaaaggggcaacagagaaccugggauuauauuccaaaaagaaauugcauguggg ......................<<<<<......<......>.......>>>>.>.........<<....>>..<<<<<<......<<.....>>....>>>>>>...<<<...<<<<...<<<<<<<......>>>>>.>>.....>>>>..........<..<<....<<....<......<<<<......<<<<.......>>>>.....<<........>>......>>>><<.......((.....>>)).......>......>>......>>>............<<<<<<<........>>>>>>>......<<<<<........>>>>>..>>>....................................<<....>>................<<<<....>>>>..................................(((..<<<<<<.<<<<<<..((.<<<<.<<<<<<<<....<<<<<..<<<<<<<<<........>>>>>>>>>...>>.>>>.........>>>>..>>>>........<<<<<.....<<...<<<..<<..>>....>>>...>.>...>>>>>.....<<<<...>>>>))..>>>>>>>>>>>>..))).<<<<........>>>><<<<<<....<<<<<<<.<<<<<..<<<...<<.<............>>>...>>>...<<....>>..<<<<<.....>>>>>...<<<<<...<<.<<.>>.>>....>>>>><<<<<<<<<.>>>>>>.>>>...>>>>>.>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<.<<<....>>>.>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>...<<<<<....<.<<<....>>>.><<<<<<<<<.....<<...<<<<<<<...<<<....<<<....<<<..>>>....>>>..>.>>...>>>>>>>.....<<<.<<<<<.<<.....>>>>>>>>>>...........>>...>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>...<<<<......>>>>..<<<<<<<...<<<(((......<..<<<<........<...........<<<.<<<<<<<<<<..>>>>>>>>>>>>>..........))).>....>>>>.>.........>>>...>>>>>>>((((.<<<<<...........>>>>.........>>>>>))))....>>>>>....<<<<<<<<.........<<<..<<<....>>>.>>>.......>>>>>>>>........>>>>>>..............<<<<<<<..................>>>>>>>....................<<<<<....<<.....>>..>>>>>....<<..........<<.<<<<<......>>>>...............<<...>>......>.>>..........<<<...........>....>>.>>........... ......................(((((......(...[..).......)))).).........((....))...((((.......((.]...)).....))))....((((..((((..((((((((......))))).))....)))))..........(......(..(............(((......(..(.......)..).....((........))......))).(((...).{[[.....))]]..............).....)...).......)....(((((((........)))))))......(((((........)))))..)))....................................((....)).............(..((((....))))............)......................((..((((((.((((((..((.((((.((((((((....(((((..((((((((..........))))))))...)).))).........))))..))))............(...............((()))................).........[[[[...))))))..))))))))))))..))..((((........))))((((((..(.(((((((.(((((..(((...((.((....}.....))))...)))...((....))..(((((.....)))))...(((((...((.((.)).))....)))))((..((((...))))...))...))))).)))))))..((.(...((((((.....((((((((((.((((...(((.(((....))).)))...).)))...(((..((.((........)))).)))..).))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)(((((((((.....((.(.((((((....(((....(((..(.(((..))).)..)))..)).)....)))))).....(((.((((..((.....)).)))))))..........)))...))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(..(..((((........(...........(((.((((((((((..)))))))))))))..........]]].)....)))).))........)))...)))))))((((.((((((..........]]]]...).....)))))))))....))))).)(.((((((((.(......((((..(((....))).))).)...).))))))))..).....))))))..............(((((((..................)))))))....................(((.(....((.....))..).)))....((......(...((.(.(((......))).............(...(...)...)...).))....).....((((.........))....)).))........... CryoEM structure of the Leishmania donovani 80S ribosome at 2.9 Angstrom resolution; LSU-alpha 5t2a B 1064 2.9 RF02543,RF02540 URS0000B21DCF_5661 27752045 0003735 0005840 5661 cccaacugcagaccguacucaucaccgcaucagguccccaagcauagaaugcucugguacauagagaaagguacacucagggaagucggcaaaauagaugcguaaguucgcaagaagcauuggcucugagggcaauugccaacucagaacugcuuacggcggggaauccaacuguauaauuaaaacauagguuugugaugcauccaagugguguauaucgcaaacugauuucugcccagugcucugaaugucaacgugacgagauucaccgacgcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucuuccaauuagagacgcgcaugaauggauuaaugagauucccucugucccgaguuacuaucuagcgaaacgacagucaagggaacggacuugaagggcuaagcggggaaagaagacccuguugaguuugacuccagucuggcucugugcggcgacguugcuucacuuaucgaaugaagagaccaaugggcgugcuguaaacugaaccaacggguccggagucuuguuucgagacaucugccagauggggaguuuggcuggggcggcauaucuguuacacgacaacgcagguguccuaaggcgagcucagugggaacagaaaucucacguagaacacaagcguaaaagcuugcuugauuaacgauuuccaguacgaaucgagacugcgaaagcaaggccagcgauccuuugcgaagaauaggaaauaugaacaaaucauaccagaggugucagaauaauuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaaccuagcgccgcagaagacgcuaaggguuggauuguucacccacugacagggaacgugagcuggguuuagaccgucgugagacagguugguuuuacccuacuuagcuggaaauugcgagaaaagauuauccgcgcaaagcggaggcaguccgucugggucugccguucgguggcaugugcuuggcgcugccaucuc ........................<<......>>......<<<<.....>>>>........<<<<....<<<<.<<<<.<<.........<.....<<<<<...............>>>>><<.<<<<<<<<<<..>>>>..>>>>>>.>>..........<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.....<<....<<<<......>>>>....>>..>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>>.>>>>............<<<<<........>>>>>..<<<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<...<<<.<<<<<..>>>>>.>>>...<<<<<.....<<<<...........................<<<..>>>..>>>>...>>>>>.......>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<......>>....>>>>>>>...<<...<<<<<.......>>>>>..>>.<<<....>>>.>>........<<<<<<..............<<<<.......>>>>.>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<<<<<<<.<......>.>>>>..>>>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>>>......................<<<<.....>>>>.<<<<<<<<....>>>.>>>>>....<<<<<<<..<.......>.>>>>>>>.. ........................((......))......((((.....))))........((((....((((.((((.((..(....(.......(((((....(.[..).....)))))((.((((((.(((())))...)))))).))..........(((((((((...((.........))...(((((((....((.(.....).))......))))))).].(((.(((..((((((.....((....((((......))))....))..))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).)))).........[..(((((......].)))))..(((((((..(((.((......((((.((((((..(((((.(((((((...(((.(((((()))))).)))...(((((.....((((...........................(((())))..))))...))))).......)))))))..)))))...((......[))..((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][..[.))....))))))).(.((...(((((.......)))))..)))(((....))).)).].].....(((((.(............((((.......))))))))))....).....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(((((((.(......).))))..))).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))....))..))).)))))))........................((.....))...((((((((....))).)))))....(.((((..(.(.....)..))))).).. CryoEM structure of the Leishmania donovani 80S ribosome at 2.9 Angstrom resolution; LSU-beta 5t2a C 162 2.9 RF00002 URS0000B21DFA_5661 27752045 0003735 0005840 5661 aacgugucgcgauggaugacuuggcuuccuauuucguugaagaacgcagcaaagugcgauaagugguaucaauugcagaaucauuaauugcccaaucuuugaacgcaaacggcgcaugggagaagcucgagccauccccgugcaugccacaucucagugucg .........................................<<<<<<.((.....>>>.....<<<<<......))............>>>>.>...>>>....<<.....>><<<<<<<....<<<..>>>....>>>>>>>................... .........................................((.(((.[[.....))).....(((.(......]]............).)).)....))....((.....))(((((((....((....))....)))))))................... CryoEM structure of the Leishmania donovani 80S ribosome at 2.9 Angstrom resolution; 5.8S rRNA 5t2a D 119 2.9 RF00001 URS00003CFFBF_5661 27752045 0003735 0005840 5661 gaguacgaccacacuugagugaaaacaccauaucccguccgauuugugaaguuaagcacucacaggcucaguuaguacugaggucagugaugacucgggaacccugagugccguacucc <<<<<<<......<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<......<<<<<..<<....>>.>>>>>.....>>>>>>..>>>>>>>. (((((((.(....((((((((.....(((.((...(....)...)).)..))....)))))).))((((((......(((((..((....)).))))).....))))))).))))))). CryoEM structure of the Leishmania donovani 80S ribosome at 2.9 Angstrom resolution; 5S rRNA 5t2a E 169 2.9 URS00005C6F67_5661 27752045 5661 gugguaaugcgcacuugccagguaacaaaucaauccucccacggugagcuuucuuuucaccauaauccacuugggccuuuuuacgcguuguucggagcgggggcucaagauugaaaaaugcagcucguacugugugaguucugcgcauuaaagcaaaaaccuggggugu <<<....>>>..<<<..<<<<<<.......<<...<<<....<<<<<<.......>>>>>><...<<.<<<<<<<<<<<<...<<.......>>....>>>>>>>>>>>.>.>>....><<<<......>>>>..>>>...>>...............>>>>>>>>>.. (((....)))..(((..((((((.......((...((((...((((((.......))))))(...((.((((((((((((...((.......))....))))))))))).).))....)((((......))))).)))...))...............))))))))).. CryoEM structure of the Leishmania donovani 80S ribosome at 2.9 Angstrom resolution; srRNA1 5t2a F 71 2.9 URS0000B21DDB_5661 27752045 5661 aucgaaucgccaccuacaagacuggagcuugcucccucgaaggcgccaaguauauucaugaucacaagaaa ........<<<............<<<<<..>>>>>......>>>........................... .......((((............(((((..)))))(..)..))).......................)... CryoEM structure of the Leishmania donovani 80S ribosome at 2.9 Angstrom resolution; srRNA3 5t2a G 183 2.9 RF02543,RF02540 URS0000B21DF5_5661 27752045 0003735 0005840 5661 gugagauugugaagggaucucgcagguaucgugagggaaguaugggguaguacgagaggaacucccaugccgugccucuaguuucugggguuugucgaacggcaagugccccgaagccaucgcacggugguucucggcugaacgccucuaagccagaagccaaucccauguccagaugcccac <<<<<<<.........>>>>>>>.<<<<<<....<<<<.<<<<<<<<...............>>>>>>>><<<<<...<.<<....<<<<<<<<<......>>>>..>>>>>...>>.>..>>>>>.<<<<....<<<<...........>>>>....>>>>.>>>>.......>>>>>>... (((((((.........))))))).(((((((...(.(..(((((((......(....).....)))))))(((((...(.((....((((((((((....)))))..)))))...)).)..))))).((((....(((.............)))....))))..).).....).))))))... CryoEM structure of the Leishmania donovani 80S ribosome at 2.9 Angstrom resolution; srRNA2 5t2a H 93 2.9 URS00002F522C_5661 27752045 5661 gucccucuccaaacgagagaacaugcaugggcuggcaugagcggcgaggggcagucccgaggcgcugaaccuugaggccucaugcucagggac <<<<<<<<<.......>>>>....<<<<<<<<.<<.....<<<....<<<<<.>>>>>....>>>....>>.....>>>.>>>>>...>>>>> ((((((.((.......)).)....((((((((.((.....(((.(..(((((.)))))..).)))....)).....))).)))))...))))) CryoEM structure of the Leishmania donovani 80S ribosome at 2.9 Angstrom resolution; srRNA4 5t2a 2 1814 2.9 RF01960,RF01959,RF00177 URS000004D6B4_5661 27752045 0003735 0005840 5661 gaucugguugauucugccaguagucauaugcuuguuucaaggacuuagccaugcaugccucagaaucacugcauuugcaggaaucugcgcauggcucauuacaucagacguaaucugccgcaaaaaucuugcgguuuccgcaaaauuggauaacuuggcgaaacgccaagcuaauacaugaaccaaccggguguucuccagugagacgcccagcgaaugaaugacaguaaaaccaaugccuucacuggcaguaacacccagcaguguugacucaauucauuccgugcgaaagccggcuuguuccggcgucuuuugacgaacaacugcccuaucagcuggugauggccguguaguggacugccauggcguugacgggagcgggggauuaggguucgauuccggagagggagccugagaaauagcuaccacuucuacggagggcagcaggcgcgcaaauugcccaaugucaaaacaaaacgaugaggcagcgaaaagaaauagagcauuucaaugggggauauuuaaacccauccaauaucgaguaacaauuggaggacaagucuggugccagcacccgcgguaauuccagcuccaaaagcguauauuaaugcuguugcuguuaaaggguucguaguugaacugugggcugugcaguuccuggucccguccaugucggauuuggugacccaggcccuugcagcccgugaacauucaaagaaacaagaaacacgggagugguuccugggcguccguguuuuacugugacuaaagaagcgugacuaaagcagucauuugacuugaauuagaaagcaugggauaacaaaggagcagccucuaggcuaccguuucggcuuuuguugguuuuaaaggucuauuggagauuauggagcacggccucuaggaaugaaggaggguaguucgggggagaacguacuggggcgucagaggugaaauucuuagaccgcaccaagacgaacuacagcgaaggcauucuucaaggauaccuuccucaaucaagaaccaaaguguggagaucgaagaugauuagagaccauuguaguccacacugcaaacgaugacacccaugaauuggggaucucuauucgcacgggaauauccucagcacacgcgaaagcuuugagguuacagucucaggggggaguacguucgcaagagugaaacuuaaagaaauugacggaauggcaccacaagacguggagcgugcgguuuaauuugacucaacacggggaacuuuaccagauccggacaggaugaggauugacagauugaguguucuuucucgauucccugaaugguggugcauggccgcuuuuggucgguggagugauuuguuugguugauuccgucaacggacgagauccaagcugcccaguagaauucagaauaauucuucucugcgggauuccuuuguaauugcacaaggugaaauuuugggcaacagcaggucugugaugcuccucaauguucugggcgacacgcgcacuacaaugucagugagaacaagaaaaacgacaaccuacuugaucaaaagaguggggaaaccccgucacauagacucacuugggaccgaggauugcaauuauuggucgcgcaacgaggaaugucucguaggcgcagcucaucaaacugugccgauuacgucccugccauuuguacacaccgcccgucguuguuuccgaugauggugcaauacaggugaucggacaggcccgaaaguucaccgauauuucuucaauagaggaagcaaaagucguaacaagguagcuguaggugaaccugcagcuggaucauuu ...<<<<<.{.[[[[>>>>><<<<.<<<<<<...<<<..........<<<.<<<..<<....<<....<<<......>>>...>>.>>......<<........<<<..<<..<<...<<.<<.....<<<<<<...>>>>>>...<<.....<<<<<<.....>>>>>>......>>..........<<<<..<<<<....>>>>.>>>>.<<<<<<<<<<.....{.((((((((<<<......>>>.........................>>>>>>>>...>>....<<<<<......>>>>>...>>.>>..>>>>..>>>.<<<....<<<....<<<<<.<<.......>>.>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<.<<<..........>>>.>>.<<<<....>>>>...>>>>>>.........<<<....<<<..........>>>..>>>.......>>>....<<.....>>......<<<............>>>...............<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>>.........<<<[[.....<<<<...<<<..<....<.<...<<<<..<.........<<<.......>>>...........>.....>>>>...>.>......................<<<<<<.......<<..>>..>>>>>>..<<<<<<<<.......<<...<.......>..<<<....>>>.....>>......>>>>>..>>>...........<<..<<<<<<.<<<...>>>.....)))))))).}..>>>>>>..>>.......<<<........>>>.....>......<<<<<..<<...<<<<<<<<..<<<<.<<<...<<<......>>>......>>>.>>>.>.>>.......<<....>>.>>>>>>...>>>>>.>>....>>>...>>>>...<<<<<<<<...<...<<<<.........>>>>...>>>>>>>>>.........<<<.<<......<<<<<<<<....<<<<......>>>>>>>>>>>>.....<<..]]>>.....>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..]]]].}<<<<<.<<<<<<<..<<...<<<<.....<<<<<.<......<<........>>..........<<.<<......<<<..........<<.<<<........>>>.>>........>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<<<.....<<<<<<......>>>>>>.....>>>>....<<<<.<<......>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>.......>.>.>>....>..>>>>>...........<....................<<<<<<<........>>>>>>>................>..............<<.<<<.......>>>..>>............>>>>......<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<<<<<..<<.<<<.<.<<<<..<<<<<.<...<.<..>.>...>.>>>>>..>>>>.>.>>>.>>..>>>>>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))((((.((((((...(((...((.....(((.(((..((....((....((.(....).))...)){))......(((.......(((..((..((...((.((......(((((...)))).)...((.....((.(((.....))).))......))..........((((..(((((.).)))).)))).((((((((((........[[[[[[[(((......)))................(......).))))))))...))....(((((......)))))...)).))..))))..))).(((....(((....(((((.((.......)).))))))))......)))..(((.((((....))))....)))))).((.(((..........))).)).((((....))))...)))))).).....(.(((...((((.}........))).))))).)....)))....((.....))...(.((((............))).....)......)..(..(([[....(.((((.....((..]])).......)))))))..)..))))))))))..{......((({{...(.((((...(((..(..........(((.(............((.......)).................).)))............................((((((...(...((()))).))))))..((((((((.......((..((.......)).(((....))).....))......)))))..)))........(..((..((((((..(.....)......]]]]]].]....))))))..))........(..(...)...)..)...)....(.(.(((...(...((((((((...((.((((...((........))......))).)))...)).......((....)).))))))..)..)))..)...))))...))))....((((((....(...((((.........))))...).))))))......<...(((.((...(..((((((((....((((......))))))))))))..)..((..}})).....))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((...((.(.....((..(........((........))..........((..(......................((..........)).................((..((...(.((((((....(((.(((((....)))....(........)....)).))).....((((.((((.......(((........))).......))))......(..((......)).).........)))).....))).))).....).)).)).......)...)).......)..)).................................(....(.........)...)....................................(..........)................).))......(((.(((.........))).)))......))...)))))))))).))..(.(..((.(.((((((((..((.(((.(.(((((.(((((.(...(.(..).)...).)))))).)))).).))).))..))))))))..).))...)..)..(((((((((....)))))))))>........ CryoEM structure of the Leishmania donovani 80S ribosome at 2.9 Angstrom resolution; 18S rRNA 5t2c B 120 3.6 RF00001 URS00000F9D45_9606 27752045 0003735 0005840 9606 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. CryoEM structure of the human ribosome at 3.6 Angstrom resolution; 5S rRNA 5t2c C 156 3.6 RF00002 URS0000005270_9606 27752045 0003735 0005840 9606 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<.<<.....>>>.....(.<<<......>>.............>>>..)...>>>....<<....>><<<<<<<<.......>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))((((((((.......)))))))).................... CryoEM structure of the human ribosome at 3.6 Angstrom resolution; 5.8S rRNA 5t2c A 3776 3.6 RF02543,RF02540 URS000086853A_9606 27752045 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcggcccggcggaucuuucccgcgcgggggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucggccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcgcucuccccccucccggcgccgccggggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccgggggaggggccacgcgcgcgucccccgaagagggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcacacgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcgugagccgggcguggaauggagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagcggcgggggcggcgcgcgcgcgcgcccgcccccggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcugggucggucgucggccggcgccuagcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacaugagagguguagaauaagugggaggcccccggcgcccccccgguguccccgcgaggggcccggggcgggguccgccggcccugcgggccgccggugaaauaccacuacucugaucguuuuuucacugacccggugaggcgggggggcgagccccgaggggcucucgcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccggucccccgcgggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcacgccguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<<....<......>.....>>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..[[[..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>>..<<<<<<<<<....<<<<<<<<........<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>...>>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<......>>>..................................<<<<<<<<..<<<.......<<<<<<<.<<<.....<<<<<<<<<<<...<<<.<<...<<<.......<<<<.<<<...<......>.>>>>>>>..>>.>..>>....>>>.>>>>>>>>>>>......>>>.>>>.>>>>...<<<<<<<<.<<<<<<<<<<.<<<....<...<.<..<.<<<....<..<<<<<..>>>>>..>.....>>>.>.>.>.........>.>>>...>>>>>>>>>>....................<<<<<..<<.<<.................>>.>>...<.<<......<<<<<<<<<<<<<<<<.<<<<<..<.<........>>...>>>>>.>>>>.>>>>>>>>>.>>>..........>>.>........<<<<.............>>>>........>>>>>......>>>.>>>>>....>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<......>>>>>>>..<<<<<...<<<..<<<.....{..[[.>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<............<<<<<<<<<...<<<....<<<..<.<<<....<<.............>>..>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<........>>>>>>>>>...>>...>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<..<.....................>.......................>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<..........]]..}........................................................>>>>>>>>>....>>>>>>.<<<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>.>>.....>>>>>><<<....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<.<.<.......>.>.>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<.....<<<<<<<....>>>>>>>...<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<<<<<<<<<<<<..{{{..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>.>.>>>>>>>>>>>>.........>>>>>>>..>.............>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<......<.....>...........>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.....<<.....<<<<....>>>>.....>>..>>>>..>>>>>.<<.............>>.........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>...>>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<.<<..<<........................<.........<.......<<.....>>......>....>........................................>>..>>..>>>>>>>>>...<<<<<.....<<<<.....<<<<<......>>>>>................<<<<<<<<<<.......>>>>>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>....<<.....>>...<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))]......((((((..(((..>>>>>>.)))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]].....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<.}}}..>>>>..>>.>>...>>>>...>>>><<<<....<<<<<...........>>>>>....>>>>.>>>...>.>>>>>>.....<<<<<<<.....<<<.....<<.........<<<<<..<.<<..>>.>.>>>>>........>>....<<...<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>...>>..............>>>....>>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<....<<<<<......>>>>>...>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..(((((((((((.....)))))).))))....))))....((((((.((.....((((.((...(....((((((((..({((((......)))))....[[(...).(((....}]])))...).))))))))..)).))).)...)).))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.......(((((((.(((.....(((((((((((...((((...((((..(....(((((.(((............)))))))).)).)))..)...))).)))))))))))......))).))).))))...((((((((.((((.(((((.(((........(.(.((.((.(...(..(((((..)))))..).....))).))).)...........)))...))))).))))....................(((((..(.(.(((.............))).).)...(.((....(.(((((((((.((.(((.(((((..................))))).)).).)).)))))).)))...)......)).)...........(((.........)))...........)))))......))).)))))....)))...)))))))).[((((........))))((((((....(((((((((((((..(((..(((((........)))).)...)))...((....))...((.((((......)))).))..(((((...(((..(((...[.[...[.)))..)))....))))).(((((((((.((((......))))))))))).))....)))))))))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)<)))...(((..((.((........)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((............(.((((((....(((....(((..(.(((.......(......)........))).)..)))..)).)....))))))...(((((((((........)))))))))....)...)))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.....{..((.....................................(........).....))....)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((..........]....]]......................................................)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...((....(((....)))..........((.((((.............))))))......))....))...(((((........)))))]]((((....(((.....(((((((....)))))))..((((....)))...(...((((((...(((((((((((((((((((((((..{{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....(((((((.......))))))))))).).))))))))))))(...)....))))))...))............))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((........................)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.....(......((((....))))......)..))))..))))).((.............)).........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.(.......((((.((((((..(((((.(((((((((.(((((((....((..((.....................................................................................................)).).).....)))))))...(((((.....((((.....(..............)................((((((((((.......))))))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(.(((.(((((....{..)))).)))))(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).)))).....)..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}}.)))))..)).))...))))...)))).(((....((((.....}.......))))....)))..)))...).))))))......(((((......(((.....((..........((((.............)))).........))....(....(((....((...(((((((......)))))))..))...)))....)..............))).....))))).(((((.(..(.......)..)....((.(((((((.((.....((((.(..(((((......)))))..)))))....))....)))).))).))..))))).. CryoEM structure of the human ribosome at 3.6 Angstrom resolution; 28S rRNA 5t2c AA 1742 3.6 RF01960,RF01959,RF00177 URS0000868520_9606 27752045 0003735 0005840 9606 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucgcuccucucccacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgccccccguggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuccgcgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcgggcguccccgccgccucucggccggggcccgaagcauuuacuuugaaaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggucggcccacggcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<..[.((((.>>>><<<.<<<<<<.....<<.........<<<.<<<..<<....<......<..........>.....>.>>......<<........<<<......<<....<<<....................<.<....<<.<<<.....>>>.>>......>>..........<<<....<<<<.....>>.>>....>>>.<...<<<<<...<......>..>>>>>........>..<<<<..<<........>>.>>>>....>>>...>>....>>>.<<<....<<<.....<<<<<<.........>>>>>>.>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>...<<....>>.....>>>>>>.........<<<....<<<.....>>>..>>>......>>.......<<.....<..............>.......>>......<<..<...........>..>>.........<<<<<<<........[......((..>>))........]...>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<................................................<<<.<<.<.......<<...<.......>..<<.........>.>...>>......>.>>...>>>.......<<.....<<<<..................>.>>>....>>....>>....<<<<<<..<...<<<<..<<<.<<<<<<<<...<<<......>>>......>>>>>>>>.>>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<........>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<......>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<..<<<<.........<........>...........<<<<<.......<<<<........<<..<<........>>..>>......>>>>....<<...<.....<<<<<<....<<<.<<<<<....>>>...<<........>>...>>.>>>....<<....<...<<<....<.<..........<........>..........>.>...>>>..>.....<<<<<.....>>>>>.........>>....>>>.>>>.......>..>>.......>>>>>......>>>>..>>........<<.........<.......<<..<<<<....>>>>..>>....>..........>>.........<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<...<<<.<<...<<<<<<<..........................>>...>>>>>...>>.>>>...>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...[[....(.(((....]]((..((..((...(.(....(.....(.(.((...((....((.....(..........)....)).)).......((.......(((.(....((.....((.....................(.....((..((.....))..))......)...........(((....((..........))....))).....((..(...(......)..)..))......(.)..((((...............))))....))....))..).)))..((....(((....(((((((.........))))))))))......))....(((.((((....))))....)))))..((.(((..........))).))...(.......).....))).).).....(.(((.....(.......)...))))......).).....(..(...((............).)...)...)......((.................)).........((((([[......(((......((..]]))........))).)))))..))..))..))..[......(.(.[...(.(.((....((....................................................(..((.(.......((..............(((.......)).)...))......).))....)........(.......(..((...............))...).....)..........((((((..(...((((..((..((((.(((...((........))......))).))))..)).......((....))...))))..)..))).)))...))....)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.(.((((.(((........)))))).)).)..)))...((.]..))...))...].))))).).(((.......(((....))).....)))...))).)((.(..(((((((...(..(((....(....(((((.......(........)...........(.(.(...................(...................).............((.(.......((((((.(..((..(((((....)))..(.((......)))...))..))....(((...(...(.((.....(..(.......((......)).....)....)....)).)...).....((((.....)))).........))).)..))).))).........)))........)).)...)).)))....)........((.........(.......(((.((.(....).)).)))....)..........)).........(.....(((((..........))))).....).......)))........(...............).........)....))))))).)..))..(.(..((.(..(.((.(...(.((((((((.(((..(.((.((...((.........(.................)...........))...)).)).)..))).)))))))))...).)).)...).))...)..)..((((.(((......))).))))}........ CryoEM structure of the human ribosome at 3.6 Angstrom resolution; 18S rRNA 5t2c An 75 3.6 RF00005 URS0000326EAC_9606 27752045 0030533 0006412 9606 agcagaguggcgcagcggaagcgugcugggcccauaacccagaggucgauggaucgaaaccauccucugcuacca <<<<<....<<<.........>>>..........................................>>>>>.... (((((.....((.........))...(.(.........).).......(.............)...))))).... CryoEM structure of the human ribosome at 3.6 Angstrom resolution; tRNA 5t3k A 17 2.142 URS000080DDA2_32630 28156044 32630 gguggugaagucgcugg ................. ................. Fluorescence detection of RNA-ligand binding and crystal structure determination of ribosomal decoding site RNA using a heavy atom containing fluorescent ribonucleoside; RNA (5'-R(*GP*GP*UP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*CP*UP*GP*G)-3') 5t3k B 16 2.142 URS000080E0EC_32630 28156044 32630 cagcgncacaccaccc ................ ................ Fluorescence detection of RNA-ligand binding and crystal structure determination of ribosomal decoding site RNA using a heavy atom containing fluorescent ribonucleoside; RNA (5'-R(*CP*AP*GP*CP*GP*(75B)P*CP*AP*CP*AP*CP*CP*AP*CP*CP*C)-3') 5t3k C 17 2.142 URS000080DDA2_32630 28156044 32630 gguggugaagucgcugg ................. ................. Fluorescence detection of RNA-ligand binding and crystal structure determination of ribosomal decoding site RNA using a heavy atom containing fluorescent ribonucleoside; RNA (5'-R(*GP*GP*UP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*CP*UP*GP*G)-3') 5t3k D 16 2.142 URS000080E0EC_32630 28156044 32630 cagcgncacaccaccc ................ ................ Fluorescence detection of RNA-ligand binding and crystal structure determination of ribosomal decoding site RNA using a heavy atom containing fluorescent ribonucleoside; RNA (5'-R(*CP*AP*GP*CP*GP*(75B)P*CP*AP*CP*AP*CP*CP*AP*CP*CP*C)-3') 5t5h A 1278 2.54 RF02543,RF02540 URS0000A76378_5693 27791004 0003735 0005840 5693 cagaccugaguguggcaggacuacccgccgaacuuaagcauauuacuaagcggaggaaaagaaaacaaccgugauucucucagucagcggcgagcgaagagggauccaacucguugccgaaucgguucuuauaggaacuugaguuguggcaauggugcaggaauggugaaauucaaagcaaacccguugcuacaucaugugaguauugagccaaagaagguguuagcccauugagccaugaaccuaagagaguagcacugcuugggagugcagugucaagcuggnagguaugugucugccaaaguuaaauacagaguaggaagaccgauagcgaacaaguagcgugagcgaaaguuugaaaagcncuuuggaaagagagugacauagaccugaagucgugacaauaauggaaguaccuccauuucgccaaaaccagccucuacugagcaagaacgaggucaugguuuuggcggaaauggggugcccccacccgucuugananncggaccaaggagunanacagacgcgcaagggagaagauaucaguacuucucucguacugaaagggagauuguggugugcacacuugcncaacaccnaccngccccggguugaguuggagugunccugnuuggacccnanagguggugaacuaugccugaacaaggugaagcccggggaaacucggguggaggccuguagcgaugcugncnugcaaaungcucgcaugauuugggunungnagcgaaagacucaucgaaccaccuaguagcugguucacaucgaaguuucccncaggauagcuggugcuugaaaaaguauugugcgguaaagcuuuaaangugcaacuugccaaagcaagguauuaaggcaccaagugggccuucuucgguaagcngagcaggcgaugcggaaugaaccgcuuagggauauguggcgucaaaacuuaugggcucacgaacaauggangacgcucaagcccaauuagugccnauuauuccuuugguaagggcgagaaaguguagcccuuccgauguagauguggcguggagguaaggacgaagcugauggcgugagccucagauggaccagccucuagugcanaunuugguuggcgunncaaagaucuaacggaacnuuggauacuggagcngggaaggauuucgugccaacggcacucguacacgaguuguucggauacugagcacaacguuacaccguuuuuagganaaggggcaacagagaaccugggauuauauuccaaaaagaaauugcaug .......................<<<<<......<......>.......>>>>.>.........<<....>>...<<<<<......<<.....>>....>>>>>....<<<..<<<<<<..<<<<<<<......>>>>>.>>....>>>>>>......<<<.<<<<<......<<<<<<<.......>>>>.<.....>......>>>.<<.......((.....>>)).....>>>>>...>>>.........<<<<<<<........>>>>>>>......<<<<<........>>>>>..>>>....................................<<....>>................<<<......>>>..............................<<<..<<<<<<.<<<<<.<<<<<<<<<<<<<<...<<.>>........>>>>..>>>>>>>>>>..>>>>>>>>>>>..>>>.<<<<........>>>><<<<<<...<<<<<<<<.<<<<<..<<<<..<<.<<<..>>>>>..>>>>...<<....>>........<<<<<...<<..>>....>>>>><<<<<<<<<.>>>>>>.>>>...>>>>>.>>>>>>>>.<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>...<<<<<....<.<<<....>>>(><<<<<<<<<.....<<...<<<<<<<...<<<.>>>...>>>>>>><<<<<....>>>>>...>>..>>>>>>>.>>).<<<<.<<<<<.....>>>>>.>>>>...<<<<......>>>>..<<<<<<<...<<<(((......<..<<<<....<..........))).>....>>>>.>.....>>>...>>>>>>><<<<.<<<<<.............>>>>>>>>>....>>>>>.....<<<<<<..........<<<..<<<....>>>.>>>........>>>>>>.........>>>>>>..............<<<<<<<...>>>>>>>....................<<<<<....<<.....>>..>>>>>....<<..........<<.<<<<<......>>>>...........>.>>..........<<<<.........>>....>>.>>....... .......................(((((......(...[..).......)))).).........((....))...((((.......((.]...)).....))))....((((.(((((..((((((((......))))).))....)))))).......((.((.((....({(((((((.......)))).((...))......))))(((...)..[[....}))]].....)).))...)).....)....(((((((........)))))))......(((((........)))))..)))....................................((....)).............(..((((....))))...........)...................((..((((((.(((((((((((((((((((((..((.)).......)))))..)))))))))).))))))))))))..))..((((........))))((((((....(((((((.(((((..(((.(.((.(((..))))).).)))...((....))........(((((...((..))....)))))(((((((((.)))))).)))...))))).)))))))..((.(...((((((.....((((((((((.((((...(((.(((....))).)))...).)))...(((..((..(........).)).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((....((.(.((((((....((...))....))))))(((((....)))))..))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(..(..((((....(..........]]].)....)))).))....)))...)))))))((((.((((((......).....)))))))))....))))).)(.(((((((..(......((((..(((....))).))).)...)..)))))))..).....))))))..............(((((((...)))))))....................(((((....((.....))..)))))....((......(...((.(.(((......)))............).))....).....((((.........))....)).))....... Structure and assembly model for the Trypanosoma cruzi 60S ribosomal subunit; RNA LARGE SUBUNIT ALPHA 5t5h B 941 2.54 RF02543,RF02540 URS0000A7636A_5693 27791004 0003735 0005840 5693 acugcagaccguacunaucaccgcaucagguccccaagcauacanugcucugguacauagagaaangnacanucagggaagucggcaaaauagaugcguaaguucgcaagaagcauuggcucugagggcaacaacucagaacugcuuacggcggggaauccaacugunuaauuaaaacauagguuugugaugcauccaagugguguaugucgcaaacugauuucugccnagugcucugunaagagguucaccggcgcggguaaacggcaagguagcnaanugccucnucuuccaauuagagacgcgcaunaauggauuaaugagauucccucugunccgaguuncuaucuagcgaaacgacagucaagggaacggacuugnagggcuaagcggggaaagaagacccunuugaguuugacnccagucuggcucugugaggcgagcuucacuuaucgaaugaagagaccaauggguuucgcguagucugcgggcuaugcaccgucucunaaccaacgganucuuguuucgagacaucugccagaugggganuuuggcuggggcggcauaucuguuacacgacaacgcaggunuccuaaggcgagcucagugggaucucacguagaacacaagcguaaaagcuugcuugauuaacgauuuccaguacgaaucgagacugcgaaagcaaggccagcgauccuuugcguangaacaaaucauaccanangugucagaauaauuacnacagngauaacuggcuuauccuucgaugucggnucuuccuaaccuagcggcuaaggguuggaunnuucacccacugacagggaacgugngcuggguuuagancgucgugagacagguugguuuuacccuacuuagcuggaaauugcgagaaaaaaaaaauuuuuuaaaauuuuuuuuuuuuuuacuugguacgaaaaaaa ....................<<......>>......<<<<.....>>>>........<<<<....<<<<.<<<<.<<...............<<<<<...............>>>>><<.<<<<<<........>>>>>>.>>..........<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<...<<..<<<<<<.<<<<<....>>>>>......>>>>..>>>>.......<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>>.>>>>............<<<<<........>>>>>..<<<<<<<..<<<.<<......<<<<.<.<<<<..<<<<<.<<<<<<<...<<<<<<<..>>>>>>>...<<<<<.....<<<<....<<.....<<<<<<<......>>>>>>>.>>.................>>>>...>>>>>.......>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<..>>>>>.....<<......>>....>>>>>>>...<<...<<<<<.......>>>>>..>>.<<<....>>>.>>........<<<<<<.<<<<<.......>>>>>>>>>>>.........>>>>...>>>>>.......<<....>.>.......<<<<<.<<<<<<..<<<<<<.>>>>..>>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>>>..................<<<..>>>..<<...>>.<<<<<<...<.......>...>>>>>> ....................((......))......((((.....))))........((((....((((.((((.((..(....(.......(((((....(.[..).....)))))((.(((((((....)..)))))).))..........(((((((((...((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(((((....)))))......))))..)))))......((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).)))).........[..(((((......].)))))..(((((((..(((.((......((((.((((((..(((((.(((((((...(((((((..)))))))...(((((.....((((....((.....((((((((....)))))))).)).................))))...))))).......)))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.(((((())))))...).((]...[.))....))))))).(.((...(((((....{..)))))..)))(((....))).)).].......(((((..((((.......)))).)))))....)}....))))..)))))).......((....).).......(((((.((((((..((((((.)))..))).(((.(.....).))).....)))))..)...))).))....(((((((....))).))))....))..))).))))))).................((((())))).(((.))).(((((((....(...)....))))))) Structure and assembly model for the Trypanosoma cruzi 60S ribosomal subunit; RNA LARGE SUBUNIT BETA 5t5h C 147 2.54 RF00002 URS000064407C_5693 27791004 0003735 0005840 5693 aacgugncgcgauggaugacuuggcuuccuauuucguugaannacgcagcaaagugcgauaagugguaucaauuncagauuaccgaaucuuugaangcaaacggcgcangggagaaauccccgugcaugccauauuucucngunucg .........................................<<<<<<.((.....>>>......<<<<......))....>>>>.....>>>....<<.....>><<<<<<<.<...>.>>>>>>>..................... .........................................((((((.[[.....))).....(((((......]]....)))).)...)))....((.....))(((((((.......)))))))..................... Structure and assembly model for the Trypanosoma cruzi 60S ribosomal subunit; 5.8S rRNA 5t5h D 114 2.54 RF00001 URS0000A76341_5693 27791004 0003735 0005840 5693 ggguacgaccauacuuggccggugcaccacaucccguccgauuugugaaguuaagcggccacaggccucguuaguacggcgaucaguggcgcuggaacccggggugcugcaauc <<.<.<<......<<<<<<<<....<<<<<..............>>>..>>....>>>>>>.>><<<<<<......<<<<<..<<.>>.>>>>>.....>>>>>>..>>.>.>> ((.(.(..(....((((((((....((((((...(....)...))))..))....)))))).))((((((......(((((..((.)).))))).....)))))))..).).)) Structure and assembly model for the Trypanosoma cruzi 60S ribosomal subunit; 5S rRNA 5t5h E 146 2.54 URS0000A76369_5693 27791004 5693 guggaaaugcggccaggugaccaaucaauccucccacggugagcuuucuuuucaccauaauccacuugggccuuucgaguuguucggaacgggggcucaagauugaaaaaugcaguugugaguucuauuaaagcaaaaaccugggg <<......>>..<<<<<<............<<<.<<.<<<<<<.......>>>>>>....<<.<<<<<<<<<<<<<<<.....>>>....>>>>>>>>>>>.>.>>..........>>.>>>................>>>>>>.. (((....)))..(((((.............(((.((.((((((.......))))))(...((.(.(((((((((((((.....)))....))))))))))..).))....).....)).))).................))))).. Structure and assembly model for the Trypanosoma cruzi 60S ribosomal subunit; srRNA1 5t5h F 46 2.54 URS0000A76332_5693 27791004 5693 cgaaucgccacuucucucggcgccaaguaccuucauauucacaaga ....<.<<<.........>>>........................> .....((((.........))).......................). Structure and assembly model for the Trypanosoma cruzi 60S ribosomal subunit; srRNA3 5t5h G 121 2.54 URS0000A7635C_5693 27791004 5693 gguaucgugaggguaguacgagguacucccaugccgunccucugguuucuggaguuugucgaacggcaagugcuccgacgcuaucgcacggugguuagccagucccaagaccagaugccca <<<<<<....<<<..<<<.<.<<...>>.>.>>><<<<<...<<<<....<<<<<<<<<......>>>>..>>>>>...>>>>..>>>>>.<<<<..>>>>..>>>.......>>>>>>.. (((((((...(((..(((.(.(.....).).)))(((((...((((....((((((((((....)))))..)))))...))))..))))).(((....)))..))).....).)))))).. Structure and assembly model for the Trypanosoma cruzi 60S ribosomal subunit; srRNA2 5t5h H 91 2.54 URS0000A76346_5693 27791004 5693 cacgucccucuccaaacgagagaacaugcaugggcuggcaugagcgcguggggccccgaggcgcugaaccuugaggccucaugcugggacu ...<<<<<<<<<.......>>>>....<<<<<<<<.<<.....<<<...<<<..>>>....>>>....>>.....>>>.>>>>>.>>>>>. ...(((((((((.......))))....((((((((.((.....((((..(((())))..).)))....)).....))).))))).))))). Structure and assembly model for the Trypanosoma cruzi 60S ribosomal subunit; srRNA4 5t62 A 3204 3.3 RF02540,RF02543 URS000061F377_559292 28179369 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauagaggguguagaauaagugggagcuucggcgccagugaaauaccacuaccuuuauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu 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........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........(.(((..(((((.((((...((((((((....{((((......)))).[[(...).(((....}]])))....)))))))).....).)).)...))))).))).)...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.(((((......(((((((((((((((((((((((.......(..((((......(((..........))).......))))..).....))))).))))))))))........(((....)))....)))))))).....))))).))))).<((((........))))((((((..(.((((((.((((((..(((..((((.......))))..)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)<)))...(((..((.((........)))).)))....))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.(((....((((((.....))))))..))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{..((((...(...((.........))...)...........(........)...))))....)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........(((.(((.....).)).)))....))....))...(((((........)))))]]((((..(((((((...((((....)))...(.[[((((((...((((.((((((((((((((((((..{{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.((((((((((.(...)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(.(.............).)........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.((((((((..((((((.((((((...........[...((......(...)...........]...))......))).))).))))))....((((.....((.(..(((..........)))..........]]...(((((......)))))..).))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))....))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}}.)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Nmd3 is a structural mimic of eIF5A, and activates the cpGTPase Lsg1 during 60S ribosome biogenesis: 60S-Nmd3-Tif6-Lsg1 Complex; TPA_inf: Saccharomyces cerevisiae S288C chromosome XII, complete sequence 5t62 B 121 3.3 RF00001 URS000055688D_4932 28179369 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Nmd3 is a structural mimic of eIF5A, and activates the cpGTPase Lsg1 during 60S ribosome biogenesis: 60S-Nmd3-Tif6-Lsg1 Complex; 5S Ribosomal RNA 5t62 C 158 3.3 RF00002 URS00001BF64E_4932 28179369 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Nmd3 is a structural mimic of eIF5A, and activates the cpGTPase Lsg1 during 60S ribosome biogenesis: 60S-Nmd3-Tif6-Lsg1 Complex; 5.8S Ribosomal RNA 5t6r A 3204 4.2 RF02540,RF02543 URS000061F377_4932 28179369 0003735 0005840 4932 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........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((.(((.(((((..(((...((((((((....{((((......)))).[[(...).(((....}]])))....)))))))).....).)).....)))))))).))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.(((((......(((((((((((((((((((((((.......(..((((......(((..........))).......))))..).....))))).))))))))))........(((....)))....)))))))).....))))).))))).<((((........))))((((((..(.((((((.((((((..(((..((((.......))))..)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)<)))...(((..((.((........)))).)))....))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.(((....((((((.....))))))..))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((...(...((.........))...)...........(........)...)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........(((.(((.....).)).)))....))....))...(((((........)))))]]((((..(((((((...((((....)))...(.[[((((((...((((.((((((((((((((((((..{{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.((((((((((.(...)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))((((...........))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((.((..(((((...........(.........(.(...))..........)...........))).))..)).)))....((((.....((((..(((..........)))..........]]...(((((......)))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))....))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}}.)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Nmd3 is a structural mimic of eIF5A, and activates the cpGTPase Lsg1 during 60S ribosome biogenesis: 60S-Nmd3 Complex; 25S Ribosomal RNA 5t6r B 121 4.2 RF00001 URS000055688D_4932 28179369 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Nmd3 is a structural mimic of eIF5A, and activates the cpGTPase Lsg1 during 60S ribosome biogenesis: 60S-Nmd3 Complex; 5S Ribosomal RNA 5t6r C 158 4.2 RF00002 URS00001BF64E_4932 28179369 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Nmd3 is a structural mimic of eIF5A, and activates the cpGTPase Lsg1 during 60S ribosome biogenesis: 60S-Nmd3 Complex; 5.8S Ribosomal RNA 5t7v A 1419 3.6 RF00177,RF01959,RF01960 URS0000BC469A_1280 28487427 0003735 0005840 1280 uggagaguuugauccuggcucaggaugaacgcuggcggcgugccuaauacaugcaagucgagcgacggcggacgggugaguaacacguggauaacuaccuauaagacugggauaacuucgggaaaccggagcuaauaccggcgaaagugaaugucacuuauagauggauccgcgcugcauuagcuaguugguaagguaacggcuuaccaaggcaacgaugcauagccgaccugagagggugaucggccacacuggaacugagacacgguccagacuccuacgggaggcagcaguagggaaucuuccgcaaugggcgaaagccugacggagcaacgccgcgugagugaugaaggucuucggaucguaaaacucuguuauuagggaagaacauauguguaaguaacugugcacaucuugacgguaccuaaucagaaagccacggcuaacuacgugccagcagccgcgguaauacguagguggcaagcguuauccggaauuauugggcguaaagcgcgcguaggcgguuuuuuaagucugaugugaaagcccacggcucaaccguggagggucauuggaaacuggaaaacuugagugcagaagaggaaaguggaauuccauguguagcggugaaaugcgcagagauauggaggaacaccaguggcgaaggcgacuuucuggucuguaacugacgcugaugugcgaaagcguggggaucaaacaggauuagauacccugguaguccacgccguaaacgaugagugcuaaguguuaggggguuuccgccccuuagugcugcagcuaacgcauuaagcacuccgccuggggaguacgaccgcaagguugaaacucaaaggaauugacggggacccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaaaucuugacauccuuugacaacugcaugguugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuuaagcuuaguugccaucaucucuaaguugacugccggugacaaaccggaggaagguggggaugacgucaaaucaucaugccccuuaugauuugggcuacacacgugcuacaauggacaauacaaagggcagcgaaaccgcgaggucaagcaaaucccauaaaguuguucucaguucggauuguagucugcaacucgacuacaugaagcuggaaucgcuaguaaucguagaucagcaugcuacggugaauacguucccgggucuuguacacaccgcccgucacaccacgagaguuuguaacacccgaagccgguggaguaaccuuuuaggagcuagccgucgaaggugggacaaaugauuggggugaagucguaacaagguagccguaucggaaggugcggcuggaucacc ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<..........<<<..<<<.......>>>......<<........<<<<<<<......<<<<<<<..<<<.....<<<<<<....>>>>>>......>>>......<.......>.>>>>>>>....>>>>>>>.<<<....<<...<<<<<<.<........>>>>>>>.>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<............>>>>>.<<<<....>>>>...>>>............<.<.....<<......>.>..>.>...>.>>>>>>..<<<<.......<<<....>>>......>>>>.......<<<.........................................>>>.........<<<<<((....<<<.......<...)).>.........>>>>>>>>..>>>>>>>>>..........<<<((.....<<<.<..<<<.<<<<<<<.<<<<<<<<<.......<<<<<.......>>>>>.....>>>>>>>..>>>>>>>>>....<<<<<<<...<<<<<<<....<<<<<<<....<<<......>>>.......>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>....>>>..>.>>>....<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<.<<<<<......>>>>>.>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<.....<<<.<<..<<<<<<<<<<......<<........>>..........<<<<<<<.....................<<<<.........<.<<<<<<<....>>>..<<<<......>>>>..>>>>.>.....<.....<.<<................>>.>......<<.<.......>.>>...........>...........>...>>>.........>>>>>>>...>>.>>>>>>>>.....<<..........<<<..<<................>>....>>>..........>>......<....<...<<<........>>>...>....>.....>>.>>>.....<.<<<<.........>>>>.>.............>>>>>>>>>.>>.......<<...<<<<.<<<..<<<<<<..<<<<....<.<<<<..<<<..<<<...>>>.>>>.>>>>.>...>>>>..>>>>>>..>>.>>>>>....>>.........<<<<<<<<<....>>>>>>>>>........ ....[.[[..(.(((..]].].((((.(((((..((..((..(....(...(((..((.........))......(((.......((((.....(...(...(.(...((........(((....))).........)).........(.().)..).)...)..)....))))..((....((....(.(((.(.......).)).))..))......))...((((((((....))))...))))))).((((..(.........).)))).(..(.....).)...)))..).).....(.((....(..(.......)..).)))....))..))..(.........(((......)))........)...(...(.............................................)....)....((((([[....(((.(.....((..]])).......).))))))))..)))))))))..........((([[...(.((((...(((...(((((.((.(((..........((((.........))))........)))...)))))))....(..(.((((...((((((((....(..((.(...((........))......).))..)....).......((....)).)))))))..))))..)....))))...))))....((((((........(.((.........)).).....))))))......{...(((((....((((...((..........))...))))....((..]]))......))))))))).(((......((((....))))....)))...))).)(.(((.(.(.(....(..((.((.((((((.(..(......((........))..........(((((((......................(.((...(....(((((.(((....)))...(((......)))....))))).......((..(......................).......((.........)).........).)......)....))....)..........)))))))...)...).))))).)...(....(......(((...(................).....))).......)...)......(..........(........)..........).....)).)).....(..(..(.........)..)..)......)......).).))))..).......(....(.((.(((...(..((..((((....(..(((...((...(.....)..))..)))..)...))))..))..)...))).)).).....)..........(((((.((....)).))))).}....... Methicillin Resistant, Linezolid resistant Staphylococcus aureus 70S ribosome (delta S145 uL3); 16S ribosomal RNA 5t7v B 2768 3.6 RF02540,RF02541,RF00002 URS0000BC4677_1280 28487427 0003735 0005840 1280 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..<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<.<<<.[...((.>>>.....<<<<<<<..<<<))...].>>>.....>>>>>>>....>>....<<<....>>>.<<<<<<......>>>>>>..<<<<<<<<<.........>>>>>>>.>>.>>....<<<<<......<......>.......>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..(((....<<<<<..........>>>>>......<<<<<<<<<...<.........<<<..<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>.>..>>>>..>>>...>.>>>>>..>>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<......>>>.............}....>>>>>>>>>>>.......<<<<..<<<<......>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<.<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>.>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<.<<<<<<...<<<<<<<<<......<<...<<<<<<..>>>>>>..>>.......>>>>.>>>>>..>>>>>>..>>..<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<.<<<<........<<<.....<<......>>.....>>>....>>>>.>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<.....>>>>>>....>>>>>>..<<<<<<<.<.......<<<<<.<<....>>.>>>>>....>.>>>>>>>........>>>>>><......<.....<<<<<<.......>>>>>><<<<....<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<.<.<<<...<<<....>>>...>>>..>>>....<<<<........>>>>.))<<<<<<<......<<<...<<<<....<<<<...<<...<.......<<...[.....>>....<....<<<<...<<<...................>>>...>>>>.....>.....<...........>........>....>>...>>>.>........>>>>..>>>.....>>>>>>>>>>>..>>.....<<......>>.>>>>.<<<.......>>>..>>>>..<<<<....<<<<<<<..<<.........<.....<<<<<.....<..>......>>>>><<<<<.<.<<<<....>>>>..>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<......>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<..<<...<<<<<..<<....>>...>>>>>...>>..>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>..>>>>>>>.>>>>.>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.((......<<<<.((<<<<..<<<<<.<<<<<<<<<.<<<<.<<<<<<.<<....>>.>>>>>>.>>>>....<<.<<<<<<.....>>>>>>>>.....>>>>>>>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<....<<<<<<<...<<<<<<.......>>>>>>.....<<.((.((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>..>))))......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..))>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<.......>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>>>>>....))..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<....<<<...<<<<<<<<<<....].>>>>>..>>>>>...>>>..>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<....>>.....<<<<<<<<.........>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>. ..(.((((......(.((((((((.....(((..(((..(((.((((......((((((.[[...[.)))....(.(((((...(((]...]].)))......)))))..).)))....(((....)))(((((((......))))))).((.(((((...........)))))..)).))....(((((..........[..........)))).).........((....))...((((......((.]...)).....))))...((((...(..((..........))..)......(((((((((...............((((((((.(((...(((.(......).)))[[(...).(((.....]])))...)))...)))))))).......)))))..)))))....(..((.(...[.......).))..)......(((((].[[[[)))))..)))......))..)))..).))...............((....))....))......(..((((....))))............)).....)))))))).).....(.((((..((((..A...))))..)))).[.(.(........).).((((((....(((((((..((((..(((...(((.....)))...)))...((....))...(((.....)))......))))..)))))))..((.(...((((((.....((((((((((.(((....((((((......))))))....[)))...(((.(((((.......<))))))))..).))))))))).(.(((....[)))...).]))))))......).))..((((((.....((((....)))).((.((((((...((((.((((.....(((...((((((()))))))..)).).....))))..))))..))))))..))..((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.(.((((.....(.....((..((.(.(((..(....{..........(......)............).))).).)).))...........]]].)...)))).)))))...)))))))(.((((.....)))).)....))))))(.(((((((.((......(((((.((....))a)))))...)).)))))))..).....))))))(......((....((((((.......))))))((((....(((...((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((((.......((...((((....((((...((...(..............{.........((....(((....(.(..(((......)))....))....))).....))..........................)....))...))))(..).....))))..))......))))))))))).))).....((......))..))).(((.......)))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))(.((.(....(.......)....))).)(...).......((((.(.((.].((.........))...(((((((.....(((....))).......))))))).}((((..((..(((((.(..(((...((...(((((..((....))...)))))...))...)))).)))..)))).(((.............)))........((..........(((((.......)))))..)..)....))))...))..).)))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((((((((.(.((.((.(...(......)...).)).)).)....((...((((.....))))..)).....)))))))))..)))))..(((......[)))((((((..........]))))))([((......((((.(.(((((.........)))))...).((][.[[[))....))).).....((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......((((.((.(((..((((((.((......)).)))..))).(((((.....))))).....))).)..)...))).).....(((((((....)))))))..>.))..)))))))))))[...(((((((...((((..(.(((((.....(....)....))))).).(((((...(.((...(((((.(.(((.}..)).))...)))))...)).).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((....)).....(.(((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...)).)...))))).). Methicillin Resistant, Linezolid resistant Staphylococcus aureus 70S ribosome (delta S145 uL3); 23S ribosomal RNA 5t7v C 114 3.6 RF00001 URS0000BC469E_1280 28487427 0003735 0005840 1280 ucuggugacuauagcaaggaggucacaccuguucccaugccgaacacagaaguuaagcuccuuagcgacgaugguagucaacuuacguuccgcuagaguagaacguugccaggc .<<.<..<.....<<..<<<<.....<<<<<...............>>>..>>....>>>.>..>>.....<<...<.<............>.>....>>......>..>.>>. .(..(..(.....(..(((((.....(((((....(.....)....)))..))....))).))..)..........(................)............)..)..). Methicillin Resistant, Linezolid resistant Staphylococcus aureus 70S ribosome (delta S145 uL3); 5S ribosomal RNA 5t7v D 74 3.6 RF00005 URS0000868542_1280 28487427 0030533 0006412 1280 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcac <<<<<<...<<<<........>>>>..<<<<.......>>>>......<<<<<.......>>>>>.>>>>>>.. (((((.(..(.((.....[..)).)..(..............)......(.(...].....).).).))))).. Methicillin Resistant, Linezolid resistant Staphylococcus aureus 70S ribosome (delta S145 uL3); E-site tRNA 5tbw 1 3149 3.0 RF02540,RF02543 URS0000B21DCE_559292 29064494 0003735 0005840 559292 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........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<<.<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<......<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<<....>>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<....<....>.....>>>>><<.<<<<<<<<<<......>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<...<<.....<<<<....>>>>.....>>.>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<.....>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<..<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>..>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((.(((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))).))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((......((((........)))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...((((((.....)))))).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((..((...((.........))...))......(..............).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........(.....(.....)......)....))....))...(((((........)))))]]((((.((((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....))))..)))))))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((((.(...)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.........)))))))....((((.....((((..((((........))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).).......(((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).))....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......((((...(((.((....((.(........((((((.....)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).)))...))))..(((((.(..(.......)..).....(((((((((.(((....((((.(..(((.((..)..).)))..)))))...)))....)))).)))))..))))).. Crystal structure of chlorolissoclimide bound to the yeast 80S ribosome; 25S ribosomal RNA 5tbw 3 121 3.0 RF00001 URS000055688D_559292 29064494 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of chlorolissoclimide bound to the yeast 80S ribosome; 5S ribosomal RNA 5tbw 4 158 3.0 RF00002 URS00001BF64E_559292 29064494 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of chlorolissoclimide bound to the yeast 80S ribosome; 5.8S ribosomal RNA 5tbw AR 3149 3.0 RF02540,RF02543 URS0000B21DCE_559292 29064494 0003735 0005840 559292 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Crystal structure of chlorolissoclimide bound to the yeast 80S ribosome; 25S ribosomal RNA 5tbw AS 121 3.0 RF00001 URS000055688D_559292 29064494 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<<............>>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of chlorolissoclimide bound to the yeast 80S ribosome; 5S ribosomal RNA 5tbw AT 158 3.0 RF00002 URS00001BF64E_559292 29064494 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of chlorolissoclimide bound to the yeast 80S ribosome; 5.8S ribosomal RNA 5tbw A 1781 3.0 RF01960,RF01959,RF00177 URS00005F2C2D_559292 29064494 0003735 0005840 559292 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Crystal structure of chlorolissoclimide bound to the yeast 80S ribosome; 18S ribosomal RNA 5tbw sR 1783 3.0 RF01960,RF01959,RF00177 URS00005F2C2D_559292 29064494 0003735 0005840 559292 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...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[...............<.....<<.<<.......>>.>>......>.........<<<<<..<<....>>..>>>>>[...((((((......<<<<<<<<<<<<..>>>>..............)))))).....]...<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<<<<...<......>...>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.{{....<<<<<<.<<<..<<<<...>>>>......>>>.>>>>>>....<<<<<<....<<..<<<<.......>>>>..>>....>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[[..((((((((....>>>>>>>>.)))))))).]]].....}}....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<<<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>...>.>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<.<<<..<........>....>>>.>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((...............(.....((.(((.....))).))......).........(((((..((....))..)))))(.(.((((((......[[[[[[[..((....))......(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(((((.(................).)).)))....(.(.(.(...........))..)......)..((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.((..(((((...))))....)..)).))))))....((((((....((..(((.........)))..))....))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(((..(.((((((.....]]]]]]].)))))).).))).....))...(((..((.((...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)).))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((........((.(((........))).))......)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...(((((((........................)))))))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>........ Crystal structure of chlorolissoclimide bound to the yeast 80S ribosome; 18S ribosomal RNA 5tcu A 1464 3.9 RF00177,RF01959,RF01960 URS0000BC469F_93061 28487427 0003735 0005840 93061 auggagaguuugauccuggcucaggaugaacgcuggcggcgugccuaauacaugcaagucgagcgaacguuagcggcggacgggugaguaacacguggauaaccuaccuauaagacugggauaacuucgggaaaccguagcuaauaccggauaauauagugaaagacacuuauagauggauccgcgcugcauuagcuaguugguaagguaacggcuuaccaaggcaacgaugcauagccgaccugagagggugaucggccacacuggaacugagacacgguccagacuccuacgggaggcagcaguagggaaucuuccgcaaugggcgaaagccugacggagcaacgccgcgugagugaugaaggucuucggaucguaaaacucuguuauuagggagaacauaugugcacaucuugacguaccuaaucagaaagccacggcuaacuacgugccagcagccgcgguaauacguagguggcaagcguuauccggaauuauugggcguaaagcgcgcguaggcgguuuuuuaagucugaugugaaagcccacggcucaaccguggagggucauuggaaacuggaaaacuugagugcagaagaggaaaguggaauuccauguguagcggugaaaugcgcagagauauggaggaacaccaguggcgaaggcgacuuucuggucuguaacugacgcugaugugcgaaagcguggggaucaaacaggauuagauacccugguaguccacgccguaaacgaugagugcuaaguguuagggggugccccuuagugcugcagcuaacgcauuaagcacuccgccuggggaguacgaccgcaagguugaaacucaaaggaauugacggggacccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaaaucuugacauccuuugacaacucuagagauagagccuuccccuucgggggacaaagugacagguggugcaugguugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuuaagcuuaguugccaucauuaaguugggcacucuaaguugacugccggugacaaaccggaggaagguggggaugacgucaaaucaucaugccccuuaugauuugggcuacacacgugcuacaauggacaauacaaagggcagcgaaaccgcgaggucaagcaaucccauaaaguuguucucaguucggauuguagucugcaacucgacuacaugaagcuggaaucgcuaguaaucguagaucagcaugcuacggugaauacguucccgggucuuguacacaccgcccgucacaccacgagaguuuguaacacccgaagccgguggaguaaccuuuuaggagcuagccgucgaaggugggacaaaugauuggggugaagucguaacaagguagccguaucggaaggugcggcuggau .....<<<<..[.(((..>>>>.<<<<.<<<<<...<<<<<<<.....<<<.<<<...<<..<<........>>>>.......<<........<<<<<<<..<<...<<<<<<<.<<.<<....<<.<<<....>>>.>>......>>>>..................>>>>>>>..>>>>>>>>>.<<<....<<<...<<<<<<<.......>>>>>>>.>>>......>>>..<<<.<<<<....>>>>....>>>.>>.<<<<.<<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>...<<<<.......<<<....>>>......>>>>..................<<<<..>>>>.....................<<<<<.((...<<<<<.....<<.)).>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<.<..<<<.<<<<<<<.<<<<<<<<<.......<<<<<<.....>>>>>>.....>>>>>>>..>>>>>>>>>...<<<<<<<.<..<<<<<<<....<<<<<<<....<<<......>>>.......>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>..>.>>>....<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<..>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>...))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<.<<.....<<<<<....>>>>>...<<<<.....>>.>>.>>.>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<..<.<..............................>>.......<<<<.....>>>>.........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<..<.....<<<..<<...<<<....>>>...>>...>>>.....>..>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<..<<<<....<.<<<<..<<<..<<<...>>>.>>>.>>>>.>...>>>.>.>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.... .....((((..[......)))).((((..(.((...((((((.(....(((..(...(.(..((...()...))).)......(.(........((((((..((...(.((.((.(...(....((.(((....))).))......)..)..................)).)).)..))))))))..(((....(((...(((((((.......))))))).)))......)))..((((((((....))))...))))).).((((.((.........)))))).(.((....)).)....).))).).....(.(((...(..((....).)..)))))..).)))))...((((......(.((....)).).....))))......(....(.......(((())))........).....).......(((((.[[...(((((.....((.].])).......))))))))))..))..)))))..........[.........((......((.(.((((..(((((.((..(......(((((.....)))).).....)).))))..)).)))).)..((((((((....((((((((....((((((....((........)).......))))))....).......((....)).)))))))...)))).)))..)))......))....(((.((....(....(((.........)))....).)).)))......(...((((((..(((((((.(.((..)).).)))))))...((....)).....))))).)..].(((......(((......)))....))).......](..((.(((((((.((..((((...(.((((((((......((........))..........(((((.(..(...((.(((.....(((((....)))))....(..(....)..)..)).).))).((.((.....(((((.(....(((((((((....)))...(((......)))...)))))).....((((............(............)...................((.......))..........)))).....).).)))...)...))))....).)))))...)).)))))).).....((((.(......(((..((.....(....).....))...))).......)))))......(.....((.((..........)).)).....)......)))).......(((((.........)))).).......))...)))))))))...)..(.(..((.(.((((.(((..((((((..(((.(...(.(((...((...((.....))..))..))).)...))))..))))))..))).))))..).))...)..)..((((...((....))...)))))... Methicillin sensitive Staphylococcus aureus 70S ribosome; 16S RRNA 5tcu X 10 3.9 28487427 93061 aauguucaaa .......... .......... Methicillin sensitive Staphylococcus aureus 70S ribosome; mRNA 5tcu E 75 3.9 RF00005 URS000031D44F_93061 28487427 0030533 0006412 93061 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacc <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>... (((((((..((((........)))).(((((.......))))).....((.((.......)).)))))))))... Methicillin sensitive Staphylococcus aureus 70S ribosome; P-site tRNA CHAIN 5tcu D 76 3.9 RF00005 URS00005AA258_93061 28487427 0030533 0006412 93061 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((........)))).(((((.......))))).....((.((.......)).))))))))).... Methicillin sensitive Staphylococcus aureus 70S ribosome; E-site tRNA CHAIN 5tcu B 2755 3.9 RF02540,RF02541 URS00001450D9_93061 28487427 0003735 0005840 93061 uuaaguuauuaagggcgcacgguggaugccuuggcacuagaagccaaugaaggacguuacuaacgacgauaugcuuuggggagcuguaaguaagcuuugauccagagauuuccgaauggggaaacccagcaugaguuaugucauguuaucgauaugugaauacauagcauaucagaaggcacacccggagaacugaaacaucuuaguacccggaggaagagaaagaaaauucgauucccuuaguagcggcgagcgaaacgggaagagcccaaaccaacaagcuugcuuguugggguuguaggacacucuaugaguuacaaaggacgacauuagacgaaucaucuggaaagaugaaucaaagaagguaauaauccuguagucgaaaauguugucucucuugaguggauccugaguacgacggagcacgugaaauuccgucggaaucugggaggaccaucuccuaaggcuaaauacucucuagugaccgauagugaaccaguaccgugagggaaaggugaaaagcaccccggaaggggagugaaauagaaccugaaaccgugugcuuacaaguagucagagcccguuaaugggugauggcgugccuuuuguagaaugaaccggcgaguuacgauuugaugcaagguuaagcaguaaauguggagccguagcgaaagcgagucugaauagggcguuuaguauuuggucguagacccgaaaccaggugaucuacccuuggucagguugaaguucagguaacacugaauggaggaccgaaccgacuuacguugaaaagugagcggaugaacugaggguagcggagaaauuccaaucgaaccuggagauagcugguucucuccgaaauagcuuuagggcuagccucaagugaugauuauuggagguagagcacuguuuggacgaggccgaauucagacaaacuccgaaugccaauuaauuuaacuugggagucagaacaugggugauaagguccguguucgaaagggaaacagcccagaccaccagcuaaggucccaaaauauauguuaaguggaaaaggauguggcguugcccagacaacuaguagucgagugacacugcgccgaaaauguaccggggcuaaacauauuaccgaagcuguggauuguccuuuggacaaugguaggagagcguucuaagggcguugaagcaugaucguaaggacauguggagcgcuuagaagugagaaugccggugugaguagcgaaagacgggugagaaucccguccaccgauugacuaagguuuccagaggaaggcucguccgcucuggguuagucggguccuaagcugaggccgacaggcguaggcgauggauaacagguugauauuccuguaccaccuauaaucgaucgauggggggacgcaguaggauaggcgaagcgugcgauuggauugcacgucuaagcaguaaggcugaguaauccgguacucgggcugagcugugauggggagaagacucuucgagucguugauuucacacugccgagaaaagccucuagauagaaaauaggugcccguaccgcaaaccgacacagguagucaagaugagaauucuaaggugagcgagcgaacucucguuaaggaacucggcaaaaugaccccguaacuucgggagaaggggugcucuuuaggguuaacgcccagaagagccgcagugaauaggcccaagcgacuguuuaucaaaaacacaggucucugcuaaaccguaaggugauguauaggggcugacgccugcccggugcuggaagguuaagaggagugguuagcuucugcgaagcuacgaaucgaagccccaguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgacccgcacgaaaggcguaacgauuugggcacugucucaacgagagacucggugaaaucauaguaccugugaagaugcagguuacccgcgacaggacggaaagaccccguggagcuuuacuguagccugauauugaaauucggcacagcuagcuguguuggcuuucuaacccgcaccacuuaucguggugggagacagugucaagcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcucaaagguucccucagaaugguuggaaaucauucauagaguguaaaggcauaagggagcuugacugcgagaccuacaagucgagcagggucgaaagacggacuuagugauccggugguuccgcauggaagggccaucgcucaacggauaaaagcuaccccggggauaacaggcuuaucucccccaagaguucacaucgacggggagguuuggcaccucgaugucggcucaucgcauccuggggcuguagucggucccaaggguugggcuguucgcccauuaaagcgguacgcgagcuggguucagaacgucgugagacaguucggucccuauccgucgugggcguaggaaauuugagaggagcuguccuuaguacgagaggaccgggauggacauaccucugguguaccaguugucgugccaacggcauagcuggguagcuauguguggacgggauaagugcugaaagcaucuaagcaugaagccccccucaagaugagauuucccaacuucgguuauaagaucccucaaagaugaugagguuaauagguucgagguggaagcauggugacauguggagcugacgaauacuaaucgaucgaagacuuaau <<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.((..((.>>>.....<<<<<<<..<<.))..))..>>.....>>>>>>>...>>>....<<<....>>>.<<<<<<......>>>>>>..<<<<<<<<<.........>>>>>>>.>>.>>....<<<<<......<......>.......>>>>.>.........<<....>>...<<<<......<<.....>>.....>>>>...(((....<<<<<<<<....>>>>>>>>.......<<<<<<<<...<.<........<..<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>...>.>.>.>>>>>..>>>......<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<....>>>>..................>>>>>>>>>>>.......<<<<..<<<<......>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<.<<<<...<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>......>>>>.>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<...<<<<<<<<<.....<<<...<<<<<<<<..........>>>>>>>>..>>.>.....>>>>.>>>>>..>>>>>>>.>>..<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<..<<<<........<<<...>>>....>>>>..>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<.....>>>>>>....>>>>>>..<<<<<<<.<<......<<<<<.<<....>>.>>>>>...>>.>>>>>>>........>>>>>><......<.....<<<<<<.......>>>>>><<<<....<<<<<.<<<..<<<<<<...<<.....>>.>>>>>>.....(<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<..........>>>>).<<<<<<.......<<...<<......<<<<...<<...<....<.<<<.....{...>>>.>.<....<<<<<..<<<...................>>>..>>>>>.....>....................>....>>...>>>.>..........>>..>>.......>>>>>>>>>>.>>>.....<<......>>>>>>>.<<<.......>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<....<....>.....>>>>><<<<<<<.<<<<....>>>>.>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<<..<....>...>>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>.>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[.<<<<..<<<<<.<<.<<<<<<.<<<<.<<<<<<<<<<..>>>>>>>>>>.>>>>....<<.<<<<<.......>>>>>>>.....>>>>>>.>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>...]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.}..>>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<.............>>>>...>>>>.>>>>.......>>>>>>>.<<......>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>. ((.(((......((((..((.(.....(((..((((((((.((.(......((.(((.[[..[[[)))...].((.((....((.]]..]]..)).......)).))....))....(((....)))(((((((......))))))).(((((((.(.........).))))).)).).....(((.(.....................).)).)..........(....)....((((......((.....)).....))))...((((.....((((((....))))))......{.(((((((((..................(((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))..........)))))..))))).....(((......[..........))).....}.(((((]..[[[)))))..)))......))..)))))).))...............((....))....))......(..((((....))))............))......)))..)))).....(.((((....((..[...).)...))))...(.(........).).(((.((....(.(((((..((((...((...((.......))...).)...............((.....)).......))))..))))).)..((.(...((((((......(((((..((.(..(...((((((......))))))...)...)....((.(.(((........)).))))...).)..)))))....(((.....)))......))))))......).))..((((.(....((((......))))(((.(((((...((.(((........(((...((((.((....(())....)).))))..)).)........).))..)).)))).)).))..((((((((..........))))))))....((........))....(.(.(((...(..[[[...(.((((((.....(.....((..(((..((.((.......(((...)))...)).))..))).))...........]]].)...)))))))..)...))))..).(.(..(....).).)......)))))....(((((.((......((.((.((....))])).))...)).)))))..........)).)))(......((....((((((.......))))))(.((....((((..((...((((((...(.......).))))))......((((.((.........(((....))).........))....((((........))))...((((((....(...(...((.(....(((((.........(............{...............(((....(.....................)....)))..........................).........)))))(..)......)))..)...)....))))))))))..)).....((......)).)))).(((.......)))..)).)..((((....(((((..(.((.......(.......(((((....(.[..).....)))))(((((....((.......))...)))))(...).......(((.((.((...((.........))....(((.((.....(((....))).......)).)))..]((..(.((..((..(((..(((...((...((.((..((....))...)).))...))...))))))....)))).(((((.........)))))........((..........(.((.........)).)..)..)....).))...))..)).))).)...)).)..))))).)))))).....)).[..(((((......].)))))..(((..((..(((.((......(((.......(..(((((.(.((((.((.((((.((..(.((((..)))).)..)).))))....((.(..(.(.....).)..))).....)).))).))..)))))..(((......[)))..((((..........]))))...[.(.....(((((.(.(((((.........)))))...).((][.[[[))....))))).....((((..(((...{..)))..)))).(((....))).).]]].].....(((.(((.((..]]]...))))).)))......}......)........)))......(((((.(.((((((...((.......))...))))))...)))).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(((((((....))).))))....))..))).))..)))[...(((((((...((((..(((((((...............))))))).(((((...(((....(.((..(((((.}..)))))....)).)....))).)))))...(((....((..(............).))....))).))))..]....)))))))((........)....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))...)))).)). Methicillin sensitive Staphylococcus aureus 70S ribosome; 23S RRNA 5tcu C 114 3.9 RF00001 URS00003DF33D_93061 28487427 0003735 0005840 93061 ucuggugacuauagcaaggaggucacaccuguucccaugccgaacacagaaguuaaggucuuuagcgacgaugguagccaacuuacguuccgcuagaguagaacguugccaggc .<<.<..<.....<<<<<<<......<<<<<<.....<....>..>>>>..>>.....>>>>>.>>............<............>..............>..>.>>. .(..(..(.......(..((......(..(((...(.....)...))).....)....))..)...........................................)..)..). Methicillin sensitive Staphylococcus aureus 70S ribosome; 5S rRNA CHAIN 5tdj A 10 1.5 URS000080E19F_32630 28034958 32630 ccggcgccgg .......... .......... RNA decamer duplex with four 2'-5'-linkages; RNA (5'-R(*CP*CP*GP*GP*CP*GP*CP*CP*GP*G)-3') 5tdj B 10 1.5 URS000080E19F_32630 28034958 32630 ccggcgccgg .......... .......... RNA decamer duplex with four 2'-5'-linkages; RNA (5'-R(*CP*CP*GP*GP*CP*GP*CP*CP*GP*G)-3') 5tdk A 10 1.43 URS000080E19F_32630 28034958 32630 ccggcgccgg .......... .......... RNA decamer duplex with eight 2'-5'-linkages; RNA (5'-R(*CP*CP*GP*GP*CP*GP*CP*CP*GP*G)-3') 5tdk B 10 1.43 URS000080E19F_32630 28034958 32630 ccggcgccgg .......... .......... RNA decamer duplex with eight 2'-5'-linkages; RNA (5'-R(*CP*CP*GP*GP*CP*GP*CP*CP*GP*G)-3') 5tga 2 1781 3.3 RF01960,RF01959,RF00177 URS0000A7631D_4932 27827794 0003735 0005840 4932 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucaucuuagagaagggggcaacuccaucucagagc ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[..................<.....<<.<<<.....>>>.>>......>.........<<<<<..<......>..>>>>>[...((((((......<<<<<<<<<<......>>..............)))))).....]...<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<.<<.<..........>.>>.>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.[[....<<<<<<.<<<<<....<..>....>>>>>.>>>>>>....<<<<<<...........<.......>...........>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[...((((((((....>>>>>>>>.))))))))..]].....]]....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<......>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<.......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<<<......>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>>....>.>>>>>....>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<......<<...>>......>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>.......<<<.<<...<.........>....>>.>>>. ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[[[[[[[(((....))).....(......).)))))).)...).(.((((..((.......)).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....((....(((............))).....))......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((((.....().....))))).))))))....((((((...............................))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(......((.(((....]]]]]]]].))).)).....).....))...(((..((.((...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)).))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...((.[.))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>......((..(....................)..))] Crystal structure of the S.cerevisiae 80S ribosome in complex with the A-site bound aminoacyl-tRNA analog ACCA-Pro; 18S ribosomal RNA 5tga 1 3149 3.3 RF02540,RF02543 URS0000A7632E_4932 27827794 0003735 0005840 4932 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<<.<<<<<<<<<<<<<<<<<<<<.....<<<<......>>>>.(.......<<<......)>>>....>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<......>>>..................................<<<<<.<<<<<.<....<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<......>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>(><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<.....<<<<...<<<<<<.....>>>>>>.>>>>.....>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>).<<<<.<<<<<.....>>>>>.>>>>....<<<..[...>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<.....]....<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>>..<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<<....>>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<....<....>.....>>>>><<.<<<<<<<<<<......>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<...<<.....<<<<....>>>>.....>>.>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<.....>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<.}}}..>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((.(((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))).....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((......((((.(....).)))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...((((((.....)))))).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((.(((...((.........))...))).....(...(........).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))..............(.....)...........))....))...(((((........)))))]]((((..(((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((((.(...)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.........)))))))....((((.....((((..((((........))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(.(.((..)..).).)..)))))...)))....)))).)))))).))))).. Crystal structure of the S.cerevisiae 80S ribosome in complex with the A-site bound aminoacyl-tRNA analog ACCA-Pro; 25S ribosomal RNA 5tga 3 121 3.3 RF00001 URS000055688D_4932 27827794 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of the S.cerevisiae 80S ribosome in complex with the A-site bound aminoacyl-tRNA analog ACCA-Pro; 5S ribosomal RNA 5tga 4 158 3.3 RF00002 URS00001BF64E_4932 27827794 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of the S.cerevisiae 80S ribosome in complex with the A-site bound aminoacyl-tRNA analog ACCA-Pro; 5.8S ribosomal RNA 5tga 6 1795 3.3 RF01960,RF01959,RF00177 URS00005F2C2D_4932 27827794 0003735 0005840 4932 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccucuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccgguccgauuuuuucguacuggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<....[[[[.>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[...............<.....<<.<<.......>>.>>......>.........<<<<<..<<....>>..>>>>>....((((((......<<<<<<<<<<<....>>>..............)))))).........<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<<<<..............>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.{{....<<<<<<.<<<..<<<<...............>>>>......>>>.>>>>>>....<<<<<<....<<..<<<<.......>>>>..>>....>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[[..((((((((....>>>>>>>>.)))))))).]]].....}}....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<.<....>.>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<.......<<........>>..........<<<<<......<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<<<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>...>.>>>>>>>.......>>>>>....>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<.<<<................>>>.>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((...............((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[[[[[[...(....).......(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(.(((((.....(....).....)))).).)......(.(.(...........))..).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((..((((...............))))......))).))))))....((((((....((..(((((.....)))))..))....))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(((..(.((((((.....]]]]]]].)))))).).))).....))...(((..((.((...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)).))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((........((.(((........))).))......)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...(((((((..(..................)..)))))))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>........ Crystal structure of the S.cerevisiae 80S ribosome in complex with the A-site bound aminoacyl-tRNA analog ACCA-Pro; 18S ribosomal RNA 5tga 5 3150 3.3 RF02540,RF02543 URS0000A7632E_4932 27827794 0003735 0005840 4932 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........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<.<<<<<.<<<<<<<<<<<<<<<.....<<<<......>>>>.(.......<<<......)>>>....>>>>>>>>..>>>>>>.>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<<...........<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<<..<<<<<<.....>>>>>>>>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><..<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>...>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<<.....>.>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<...............>>>>><<.<<<<<<<<<<<..>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<..<<<.....<<<<....>>>>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<........>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<......>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<.}}}..>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((.(((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..)))))).)....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((...........(((((((((((((((((((((((.......(((((((......((((((....)))))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...(.((((.....)))).).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.......(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((..((((((....((.....))..)))))....[[(((.((...((....(((....)))........(.(....(...).....).)....))....))...(((((........)))))]]((((.((((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....))))..)))))))).))).))).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((..)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...(......((((....))))......).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(..(............)..)....((((.....((((..((((........))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.............))))...)))).))))....)))))))).......(.((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).)))).)..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Crystal structure of the S.cerevisiae 80S ribosome in complex with the A-site bound aminoacyl-tRNA analog ACCA-Pro; 25S ribosomal RNA 5tga 7 121 3.3 RF00001 URS000055688D_4932 27827794 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of the S.cerevisiae 80S ribosome in complex with the A-site bound aminoacyl-tRNA analog ACCA-Pro; 5S ribosomal RNA 5tga 8 158 3.3 RF00002 URS00001BF64E_4932 27827794 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of the S.cerevisiae 80S ribosome in complex with the A-site bound aminoacyl-tRNA analog ACCA-Pro; 5.8S ribosomal RNA 5tgm 2 1781 3.5 RF01960,RF01959,RF00177 URS0000B21DFE_4932 27827794 0003735 0005840 4932 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucaucuuagagaagggggcaacuccaucucagagc ...<<<<....[[[[.>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[..................<.....<<.<<.......>>.>>......>.........<<<<<..<......>..>>>>>....((((((......<<<<<<<<<<......>>..............)))))).........<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<.<<.<<.<..........>.>>.>>..>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.[[....<<<<<<.<<<<<....<..>....>>>>>.>>>>>>....<<<<<<...........<.......>...........>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[...((((((((....>>>>>>>>.))))))))..]].....]]....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>......<<<....>>>..>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<......>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<........<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>>....>.>>>>>......>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>......<....<<<<<<..........>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<...>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>.......<<<.<<...<.........>....>>.>>>. ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..................(.....((.(((.....))).))......).........(((((..(......)..)))))(.(.((((((......[[[[[[[[(((....))).....(......).)))))).)...).(.((((..((.......)).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.(((......)))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....((..(.(((............))).)...))......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(..(...(((.((....((((((.(((((.....().....))))).))))))....((((((...............................))))))...(((((.((........(..((.......)).(((.....)))....).......)).))..))).........(....(....(((....]]]]]]]].)))....)...).....))...(((..((.((...((((..(((.((((((.....((........))........)))))).)))......(((....)))..))))..)).))...))..))))...)..)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.((..........))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..(.((..(((((.((((((....))))))...)))))..)).).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...((.[.))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>......((..(....................)..))] Crystal structure of the S.cerevisiae 80S ribosome in complex with the A-site bound aminoacyl-tRNA analog ACCA-Pro; 18S ribosomal RNA 5tgm 1 3149 3.5 RF02540,RF02543 URS0000B21DCE_4932 27827794 0003735 0005840 4932 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........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..<<<..<........<<.<<<<<<...>>>>>>.>>........>....<<<<<<.<<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<......>>>..................................<<<<<.<<<<<<.....<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<......<<<....>>>..<<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<<..<<<<<<.....>>>>>>>>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>>..<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..[[[..>>>>>>....<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>.....<<<<<<<<....>>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<...............>>>>><<.<<<<<<<<<<......>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<...<<.....<<<<....>>>>.....>>.>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<..<<<<<<<<<.....>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))......<<<<<<<..<<<<.))))))>>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<<...<<<<<<<<<.]]]..>>>>..>>>>>..>>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<..<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>..>>>>>..<<<<<.....................<<<<<<<<<.<<<....<<<<....<<<<........>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((......((((........)))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...((((((.....)))))).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((.(((...((.........))...))).....(...(........).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...((((((...((.....)).))))))....[[(((.((...((....(((....)))..........(...(.....)....)......))....))...(((((........)))))]]((((..((((.((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....)).)..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((..(...).)))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.........)))))))....((((.....((((..(((..........)))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(..(((((...((.......))...)))))....)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((.(((....)))..)))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......((((...(.(.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).).)...))))..(((((.(..(.......)..).....(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))..))))).. Crystal structure of the S.cerevisiae 80S ribosome in complex with the A-site bound aminoacyl-tRNA analog ACCA-Pro; 25S ribosomal RNA 5tgm 3 121 3.5 RF00001 URS000055688D_4932 27827794 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<<............>>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of the S.cerevisiae 80S ribosome in complex with the A-site bound aminoacyl-tRNA analog ACCA-Pro; 5S ribosomal RNA 5tgm 4 158 3.5 RF00002 URS00001BF64E_4932 27827794 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((...(.]].)..........).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of the S.cerevisiae 80S ribosome in complex with the A-site bound aminoacyl-tRNA analog ACCA-Pro; 5.8S ribosomal RNA 5tgm 6 1795 3.5 RF01960,RF01959,RF00177 URS00005F2C2D_4932 27827794 0003735 0005840 4932 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccucuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccgguccgauuuuuucguacuggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[...............<.....<<.<<.......>>.>>......>.........<<<<<..<......>..>>>>>....((((((......<<<<<<<<<<<....>>>..............)))))).........<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<<<<<<....>>>>...>>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<<<<..............>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.{{....<<<<<<.<<<..<<<<...............>>>>......>>>.>>>>>>....<<<<<<....<<..<<<<.......>>>>..>>....>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[[..((((((((....>>>>>>>>.)))))))).]]].....}}....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<........<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<<<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>...>.>>>>>>>.....>.>>>>>......>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<.<<<..<..........>..>>>.>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((...............((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[[.[[[...(....).......(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(.(((.(................).)).).)......(.(.(...........))..).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((...(((...............))).......))).))))))....((((((....((..(((((.....)))))..))....))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(((..(.((((((.....]]].]]].)))))).).))).....))...((((.((.((...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)).))..)))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(.(......((((....))))....).)...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((........((.(((........))).))......)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...((.((((........................)))).))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>........ Crystal structure of the S.cerevisiae 80S ribosome in complex with the A-site bound aminoacyl-tRNA analog ACCA-Pro; 18S ribosomal RNA 5tgm 5 3150 3.5 RF02540,RF02543 URS0000B21DEF_4932 27827794 0003735 0005840 4932 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........................<<<<<<.....<<....>>......>>>>>.>...{.....<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<<.<<<<.<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>.>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]....}.............................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<<...........<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<<..<<<<<<.....>>>>>>>>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.........>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<......<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>....>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<<.....>.>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<...............>>>>><<.<<<<<<<<<<<..>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<..<<<.....<<<<....>>>>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<.<.....>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<......>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<.}}}..>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<....<<<......>>>....>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.((((((((.((((((((((((...({((((......)))))[[......(((....}]])))....))))))))..)))).).))...)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((...........(((((((((((((((((((((((.......(((((((......((((((....)))))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...(.((((.....)))).).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.......(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((..((((((....((.....))..)))))....[[(((.((...((....(((....)))........(.(....(...).....).)....))....))...(((((........)))))]]((((.((((((((...(.((....))....(.<.((((((...((((.(((((((((.((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))).).).))))))).))))(...)....))))))...))....))))..)))))))).))).))).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((..)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...(......((((....))))......).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(.((............)).)...(((((.....((((..(.((........)).)...........>...((((((....))))))..))))..))))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.............))))...)))).))))....)))))))).........(.((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).)).)....(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(((.((..)..).)))..)))))...)))....)))).)))))).))))).. Crystal structure of the S.cerevisiae 80S ribosome in complex with the A-site bound aminoacyl-tRNA analog ACCA-Pro; 25S ribosomal RNA 5tgm 7 121 3.5 RF00001 URS000055688D_4932 27827794 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of the S.cerevisiae 80S ribosome in complex with the A-site bound aminoacyl-tRNA analog ACCA-Pro; 5S ribosomal RNA 5tgm 8 158 3.5 RF00002 URS00001BF64E_4932 27827794 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of the S.cerevisiae 80S ribosome in complex with the A-site bound aminoacyl-tRNA analog ACCA-Pro; 5.8S ribosomal RNA 5tpy A 71 2.805 URS0000B21DE3_64320 27934765 64320 gggucaggccggcgaaagucgccacaguuuggggaaagcugugcagccuguaacccccccacgaaaguggg ..[.<<<<<<<<......>>>.<<<<<<..((((...>>>>>>].>>>>>...))))<<<<<....>>>>> ..{.(((((((((....)))).((((((..[[[[...))))))}.)))))...]]]](((((....))))) Crystal structure of an exonuclease resistant RNA from Zika virus; RNA (71-MER) 5tzs 0 364 5.1 27980088 559292 nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnggauuugguggnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn ............................................................................................................................................................................................................................................................................................................................................................................ ............................................................................................................................................................................................................................................................................................................................................................................ Architecture of the yeast small subunit processome; 5' external transcribed spacer 5tzs 2 126 5.1 RF01846 27980088 0006396 0005730 559292 nnnnnnnnnnnnnnnnnnnnnnnccacugaauccaacuugguugaugaguuaaccuuuguacccgugagaaaccguauggccgaugaucuuacccauggguggguacaaauggcagucugacaagu ....................................<<<<.............<.<<<<<<<<.<.......<<<..>>>........>..<<<<..>>>>.>>>>>>>>..>........>>>>. ...................................(((((.............((((((((((((...(...(((()))).)......)..((((()))))))))))))).))........))))) Architecture of the yeast small subunit processome; U3 snoRNA 5u4i A 2904 3.5 RF02540,RF02541 URS0000B21DEA_562 28077875 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaacccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccuu <<<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<.))).....>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<.<....<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>..>>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>>.>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<.........>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><<<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>.>>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<....<....>.....>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<.<.<<....>>...>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<<<<...<<<.<....<<<<<<<<....>>>>>>>>.>.>>>.............>>>>...>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>.. 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Structural Basis of Co-translational Quality Control by ArfA and RF2 Bound to Ribosome; 23S rRNA 5u4i B 118 3.5 RF00001 URS0000366A67_562 28077875 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (((((((.(.....((((((.(....(((((((...(.....)...))))..)))...).)))).)).((.......(.((((((...)))))).).......))...).))))))). Structural Basis of Co-translational Quality Control by ArfA and RF2 Bound to Ribosome; 5S rRNA 5u4i a 1533 3.5 RF00177,RF01959,RF01960 URS0000B21DDF_562 28077875 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccacgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<........>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<...<<....>>.>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<.......<<<....>>>......>>>>..<<.<<<<<.......<<<<<<<<<.......>>>>>>>>.>........>>>>>....>>.<<<<<(((...<<<<<........))).........>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<..<<<.......>>>..>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<<..<<<.....>>>>>.....>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .......((((..[.[[[[.)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((..(((........)))...)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....))).....((((............))))..)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...((((......(..]]].)........)))))))))..)))))))))..........((([[...(.((((...(((.(.(((...(((((((((........((.((.....)).))......)))))))..))..))).)..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((..((.......))..)))))))...((..]])).....)))))))))).(((......((((....))))....)))..]]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((....(((((....))))).......(...)...))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..((.......))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(.(((((.........))))).)......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Structural Basis of Co-translational Quality Control by ArfA and RF2 Bound to Ribosome; 16S rRNA 5u4i x 77 3.5 RF00005 URS000041AF00_562 28077875 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Structural Basis of Co-translational Quality Control by ArfA and RF2 Bound to Ribosome; P-site or E-site fMet-tRNA(fMet) 5u4i y 77 3.5 RF00005 URS000041AF00_562 28077875 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Structural Basis of Co-translational Quality Control by ArfA and RF2 Bound to Ribosome; P-site or E-site fMet-tRNA(fMet) 5u4j a 307 3.7 RF00177,RF01959,RF01960 URS000080E246_562 28077875 0003735 0005840 562 gaagaguuugaucauggcucagauugaacgcuaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccggcauggcugucgucagcucguguugugaaauguugacgucaagucuucccgggccuuguacacaccgnccgunacaccaugggaguggguucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca ...<<<<..[.((((.>>>>.<<<<.<<<<<.<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>....>>>>>>>>>..........<<<.......>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<......<<<.............<<<....>>>..........>>>......>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<..>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ...((((..[.[[[..)))).((((.(((((.((([[[...(((((.....((.]]])).......))))))))....)))))))))..........(((.....()))).(((......((((....))))....)))...]]].](((((.(((((((.....((((.(..........(((....)))......).).))).....)))))))))).))....(..((...((((.(((..((((()))))..))).))))....))...).....(((((((((....)))))))))...... Structural Basis of Co-translational Quality Control by ArfA and RF2 Bound to Ribosome; 16S rRNA 5u4j A 11 3.7 RF02540,RF02541 URS0000B21DEA_562 28077875 0003735 0005840 562 guaacuauaac <<.......>> (.........) Structural Basis of Co-translational Quality Control by ArfA and RF2 Bound to Ribosome; 23S rRNA 5u4j x 15 3.7 RF00005 URS00001BBAFC_562 28077875 0030533 0006412 562 ucgggcucauaaccc ..<<<.......>>> ..(((.......))) Structural Basis of Co-translational Quality Control by ArfA and RF2 Bound to Ribosome; P-site tRNA fMet 5u9f A 1539 3.2 RF00177,RF01959,RF01960 URS000080DDC0_562 28300532 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu 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3.2 A cryo-EM ArfA-RF2 ribosome rescue complex (Structure II); 16S ribosomal RNA 5u9f 01 2903 3.2 RF02540,RF02541 URS0000B21DED_562 28300532 0003735 0005840 562 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<<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<<.....>>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<...........>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<......>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<........>>>...>>>>>>...>>>...>>>.>........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<..<......>...>>>>>..>....>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<.............<<.<...<........<.<<<<<....>>>>>.>......>............>.>>....>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. 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3.2 A cryo-EM ArfA-RF2 ribosome rescue complex (Structure II); 23S ribosomal RNA 5u9f 02 119 3.2 RF00001 URS000080E133_562 28300532 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>> ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))) 3.2 A cryo-EM ArfA-RF2 ribosome rescue complex (Structure II); 5S ribosomal RNA 5u9f X 77 3.2 RF00005 URS000041AF00_562 28300532 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((.(.........).)).(((((.......))))).....(((((.......)))))))))))..... 3.2 A cryo-EM ArfA-RF2 ribosome rescue complex (Structure II); fMet-tRNA (P- and E-site) 5u9f V 14 3.2 28300532 562 aggagguaaaaaug .............. .............. 3.2 A cryo-EM ArfA-RF2 ribosome rescue complex (Structure II); truncated mRNA 5u9f W 77 3.2 RF00005 URS000041AF00_562 28300532 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(((((.......)))))))))))..... 3.2 A cryo-EM ArfA-RF2 ribosome rescue complex (Structure II); fMet-tRNA (P- and E-site) 5u9g A 1539 3.2 RF00177,RF01959,RF01960 URS000080DDC0_562 28300532 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<.<.......>..>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<......>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<.<<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<...<<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<.......<<<....>>>......>>>>..<<.<<<<<........<<<<<<<<.......>>>>>>>>..........>>>>>....>>.<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((.((............))..)))))..)))))......(((.......((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..(......))))))).)))))))..)).)))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......(.((....)).).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(.(((.....((.]]])).......))).))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......(((.((.....)).)))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...((((((....))))))....((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... 3.2 A cryo-EM ArfA-RF2 ribosome rescue complex (Structure I); 16S ribosomal RNA 5u9g 01 2903 3.2 RF02540,RF02541 URS0000B21DED_562 28300532 0003735 0005840 562 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<<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<.........>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<<..<<<.........>>>..>>>.........<<......>>...>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<............>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>.>........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<..<<....>>...>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<..<<............<<<<...<<.......<<.<<<<<....>>>>>.>>....>>.............>>>>..>.>..>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<.........>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((.((((((.((.(((...(((((......)))))[[......(((.....]])))...)))...)).)))))).)))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....((((......)))).((((((((..((((((((((.....(((...(((.((((...((..((.......))...))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(...((......)).).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((..(......)..)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((...(((...(((....)))...)))...)))..(((((........)))))]](((((((((((((...((((....((((..(((..(((((.((((((...{{{.).))))).((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((.(....).)))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.(...............((.(............(.(..(......)..).)...................).))......).)))))))))))...(((..(((((.....))))).)))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((.....((((....))))....))...))))).))).....))..).))))))))). 3.2 A cryo-EM ArfA-RF2 ribosome rescue complex (Structure I); 23S ribosomal RNA 5u9g 02 119 3.2 RF00001 URS000080E133_562 28300532 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.....<.<<<<<<<<...>>>>>>>>...>...>>...>>>>>>>>>> ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((.(((((...))))).)).......))...)))))))))) 3.2 A cryo-EM ArfA-RF2 ribosome rescue complex (Structure I); 5S ribosomal RNA 5u9g X 77 3.2 RF00005 URS000041AF00_562 28300532 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<.<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>.>>..... .((((((..((.(.........).)).(((((.......))))).....(((((.......)))))))))))..... 3.2 A cryo-EM ArfA-RF2 ribosome rescue complex (Structure I); fMet-tRNA (P- and E-site) 5u9g V 14 3.2 28300532 562 aggagguaaaaaug .............. .............. 3.2 A cryo-EM ArfA-RF2 ribosome rescue complex (Structure I); truncated mRNA 5u9g W 77 3.2 RF00005 URS000041AF00_562 28300532 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... 3.2 A cryo-EM ArfA-RF2 ribosome rescue complex (Structure I); fMet-tRNA (P- and E-site) 5ued A 14 1.5 28673998 32630 nnngacuuaagucg .............. .............. RNA primer-template complex with guanosine dinucleotide ligand G(5')pp(5')G; RNA (5'-R(*(LCC)P*(LCC)P*(LCC)P*GP*AP*CP*UP*UP*AP*AP*GP*UP*CP*G)-3') 5ued B 14 1.5 28673998 32630 nnngacuuaagucg .............. .............. RNA primer-template complex with guanosine dinucleotide ligand G(5')pp(5')G; RNA (5'-R(*(LCC)P*(LCC)P*(LCC)P*GP*AP*CP*UP*UP*AP*AP*GP*UP*CP*G)-3') 5uee A 14 1.9 28673998 32630 nnngacuuaagucg .............. .............. RNA primer-template complex with guanosine dinucleotide ligand G(5')ppp(5')G; RNA (5'-R(*(LCC)P*(LCC)P*(LCC)P*GP*AP*CP*UP*UP*AP*AP*GP*UP*CP*G)-3') 5uee B 14 1.9 28673998 32630 nnngacuuaagucg .............. .............. RNA primer-template complex with guanosine dinucleotide ligand G(5')ppp(5')G; RNA (5'-R(*(LCC)P*(LCC)P*(LCC)P*GP*AP*CP*UP*UP*AP*AP*GP*UP*CP*G)-3') 5uef A 14 2.1 28673998 32630 nnngacuuaagucg .............. .............. RNA primer-template complex with guanosine dinucleotide p(5')G(3')p(5')G ligand; RNA (5'-R(*(LCC)P*(LCC)P*(LCC)P*GP*AP*CP*UP*UP*AP*AP*GP*UP*CP*G)-3') 5uef B 14 2.1 28673998 32630 nnngacuuaagucg .............. .............. RNA primer-template complex with guanosine dinucleotide p(5')G(3')p(5')G ligand; RNA (5'-R(*(LCC)P*(LCC)P*(LCC)P*GP*AP*CP*UP*UP*AP*AP*GP*UP*CP*G)-3') 5ueg A 14 2.6 28673998 32630 nnngacuuaagucg .............. .............. RNA primer-template complex with guanosine dinucleotide G(5')pppp(5')G ligand; RNA (5'-R(*(LCC)P*(LCC)P*(LCC)P*GP*AP*CP*UP*UP*AP*AP*GP*UP*CP*G)-3') 5ueg B 14 2.6 28673998 32630 nnngacuuaagucg .............. .............. RNA primer-template complex with guanosine dinucleotide G(5')pppp(5')G ligand; RNA (5'-R(*(LCC)P*(LCC)P*(LCC)P*GP*AP*CP*UP*UP*AP*AP*GP*UP*CP*G)-3') 5ueg C 14 2.6 28673998 32630 nnngacuuaagucg .............. .............. RNA primer-template complex with guanosine dinucleotide G(5')pppp(5')G ligand; RNA (5'-R(*(LCC)P*(LCC)P*(LCC)P*GP*AP*CP*UP*UP*AP*AP*GP*UP*CP*G)-3') 5ueg D 14 2.6 28673998 32630 nnngacuuaagucg .............. .............. RNA primer-template complex with guanosine dinucleotide G(5')pppp(5')G ligand; RNA (5'-R(*(LCC)P*(LCC)P*(LCC)P*GP*AP*CP*UP*UP*AP*AP*GP*UP*CP*G)-3') 5uk4 u 45 3.204 URS000080E17E_30538 28396572 30538 uuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuu ............................................. ............................................. VESICULAR STOMATITS VIRUS N PROTEIN IN COMPLEX WITH INHIBITORY NANOBODY 1307; RNA (45-MER) 5uk4 v 45 3.204 URS000080E17E_30538 28396572 30538 uuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuu ............................................. ............................................. VESICULAR STOMATITS VIRUS N PROTEIN IN COMPLEX WITH INHIBITORY NANOBODY 1307; RNA (45-MER) 5uk4 w 45 3.204 URS000080E17E_30538 28396572 30538 uuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuu ............................................. ............................................. VESICULAR STOMATITS VIRUS N PROTEIN IN COMPLEX WITH INHIBITORY NANOBODY 1307; RNA (45-MER) 5uk4 x 45 3.204 URS000080E17E_30538 28396572 30538 uuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuu ............................................. ............................................. VESICULAR STOMATITS VIRUS N PROTEIN IN COMPLEX WITH INHIBITORY NANOBODY 1307; RNA (45-MER) 5ukb R 45 5.473 URS000080E17E_562 28396572 562 uuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuu ............................................. ............................................. VSV N PROTEIN IN COMPLEX WITH INHIBITORY NANOBODY 1004; RNA (45-MER) 5umd A 3191 3.2 RF02540,RF02543 URS000080E1CC_36329 28288098 0003735 0005840 36329 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Structure of the Plasmodium falciparum 80S ribosome bound to the antimalarial drug mefloquine; 28S ribosomal RNA 5umd B 118 3.2 RF00001 URS000080E122_36329 28288098 0003735 0005840 36329 gacucguucauacuacaguggauacaccagaucccaucagaacucugaaguuaagcacuguaaggcuuggcuaguacugaggugggagaccgcucgggaacaccaggugaugagucag <<<<<<<<....<<<<<<<<.....<<<<<<............>>>>..>>....>>>>>>.>><<<<<<......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>.. ((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......(((((..((....)).))))).....)))))))))))))).. Structure of the Plasmodium falciparum 80S ribosome bound to the antimalarial drug mefloquine; 5S ribosomal RNA 5umd C 151 3.2 RF00002 URS00005DAD5E_36329 28288098 0003735 0005840 36329 agcacagucuuaacgauggaugucuugguuccuacagcgaugaaggccgcagcaaaaugcgauacgcaaugaaaauugcagugacugaaucaucagaaugcugaauguaaacuacaccaauucccugggaauagugguacuccuacagaaa ............................................<<<<<<.((.....>>>.....<.<<<<..<<.)).>>.......>>>>..>...>>>....<<.....>><<<<<<<<<<.>>>>>>..>>>>............. ............................................((((((.[[.....))).....(.((((..((.]].)).......))))..)...)))....((.....))((((((((((.))))))..))))............. Structure of the Plasmodium falciparum 80S ribosome bound to the antimalarial drug mefloquine; 5.8S ribosomal RNA 5une A 47 2.9001 RF00635 URS0000B21DF6_9606 9606 gggaaaugaugggcguagacgcacgucagcggcggaaaugguuuccc ............................................... ............................................... Dimerized Structure Gives Further Insight Into the Function of the Novel RNA Gene: HAR1; RNA (47-MER) 5une B 47 2.9001 RF00635 URS0000B21DF6_9606 9606 gggaaaugaugggcguagacgcacgucagcggcggaaaugguuuccc ............................................... ............................................... Dimerized Structure Gives Further Insight Into the Function of the Novel RNA Gene: HAR1; RNA (47-MER) 5uq7 A 2867 3.5 RF02540,RF02541,RF00002 URS00001698E8_300852 29456023 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu 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70S ribosome complex with dnaX mRNA stemloop and E-site tRNA (""in"" conformation); 23S rRNA 5uq7 B 120 3.5 RF00001 URS000080DFF2_300852 29456023 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>>> (((((((.(((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).))).))))))) 70S ribosome complex with dnaX mRNA stemloop and E-site tRNA (""in"" conformation); 5S rRNA 5uq7 a 1513 3.5 RF00177,RF01959,RF01960 URS0000D56C3F_300852 29456023 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggaucaccuccuug .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<............<<<....>>>..........>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<<....>>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>...<<<......>>>...>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.............. .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(.(...(.......((.(..).)).......).).)......(((.......(((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((.(.(((((((.((......((((((.....))))))....)).)))))..))).)))))..((((((((....((((((((....((((((....((........)).......))))))....).......((....)).)))))))...)))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((.((......)).)))....(((....)))....)))))))).((.((....((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...))..))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((...((((((((((((...(.((((....(((....))).)))).)..))))))))))))...))).))))..).))...)..)..(((((((((....)))))))))}............. 70S ribosome complex with dnaX mRNA stemloop and E-site tRNA (""in"" conformation); 16S rRNA 5uq7 y 77 3.5 RF00005 URS000057545F_83333 29456023 0030533 0006412 83333 cgcgggguggagcagcccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(.(((..]....))).)))))))..... 70S ribosome complex with dnaX mRNA stemloop and E-site tRNA (""in"" conformation); P-site tRNA fMet 5uq7 z 76 3.5 RF00005 URS00005AA258_83333 29456023 0030533 0006412 83333 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... ((((.((..((((........)))).((((.........)))).....((.((.......)).)))).)))).... 70S ribosome complex with dnaX mRNA stemloop and E-site tRNA (""in"" conformation); E-site tRNA Phe 5uq7 x 55 3.5 RF00382 URS0000D56C4C_32630 29456023 0006452 32630 uaaggaaauaaaaauguuuagugaaccggcagccgcuacccgcgcgcggccggua ...........................<<<.<<<<<.....>>>.>>.>>>.... ............................((.(((((.....))).)).))..... 70S ribosome complex with dnaX mRNA stemloop and E-site tRNA (""in"" conformation); messenger RNA 5uq8 A 2867 3.2 RF02540,RF02541,RF00002 URS00001698E8_300852 29456023 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<....<<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>...<.....<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>....>.>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>.............>....>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..<<.........>>...>>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<..>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<...>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> ((.......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...((((((((.....))))))))....{.(((((((((......(...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)..)))))).))))....(((((((((.[.....)))))))))....}.(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((()))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((.([..(((((.(((...(((...((((((((.(.((((((......)))).)))..))))))))..)).)...))).)))))..).]))))))).)...(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((.(.......(((((.(((..((.(......)))...))).....(...((......)).).)))))...).)))))))).))..........]]].)....))))))))))...)))))))(((((((())))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(....(((..)))......))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...((((.((.....(((....))).......)).)))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((..((((.(((((((.(((.((((.(.........(((((..(((......((((((((....))))))))...)))............)))))).)))).))).)))))))...(((.(....).)))....))))..)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....((.((((.((..]]]]..)))))).)).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))((.(.).).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...).)) 70S ribosome complex with dnaX mRNA stem-loop and E-site tRNA (""out"" conformation); 23S rRNA 5uq8 B 120 3.2 RF00001 URS000080DFF2_300852 29456023 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>>> .((((((.(((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).))).)))))). 70S ribosome complex with dnaX mRNA stem-loop and E-site tRNA (""out"" conformation); 5S rRNA 5uq8 a 1513 3.2 RF00177,RF01959,RF01960 URS0000D56C3F_300852 29456023 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggaucaccuccuug .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<............<<<....>>>..........>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<<....>>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>....<<......>>...>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.............. .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(.(...(.......((((..)))).......).).)......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((.(.(((((((.((......((((((.....))))))....)).)))))..))).)))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((.(((....))).)))....(((....)))....)))))))).((.(((...((.(((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).))....)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((...((((((((((((...(.((((....(((....))).)))).)..))))))))))))...))).))))..).))...)..)..(((((((((....)))))))))}............. 70S ribosome complex with dnaX mRNA stem-loop and E-site tRNA (""out"" conformation); 16S rRNA 5uq8 y 77 3.2 RF00005 URS000057545F_83333 29456023 0030533 0006412 83333 cgcgggguggagcagcccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... 70S ribosome complex with dnaX mRNA stem-loop and E-site tRNA (""out"" conformation); P-site tRNA fMet 5uq8 z 76 3.2 RF00005 URS00005AA258_83333 29456023 0030533 0006412 83333 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((........)))).(.((..........))).....((.((.......)).))))))))).... 70S ribosome complex with dnaX mRNA stem-loop and E-site tRNA (""out"" conformation); E-site tRNA Phe 5uq8 x 55 3.2 RF00382 URS0000D56C4C_32630 29456023 0006452 32630 uaaggaaauaaaaauguuuagugaaccggcagccgcuacccgcgcgcggccggua ...........................<<<.<<<<<.....>>>.>>.>>>.... ............................((.(((((.....))).)).))..... 70S ribosome complex with dnaX mRNA stem-loop and E-site tRNA (""out"" conformation); messenger RNA 5ux3 A 25 2.5 URS0000CBFF46_32630 29411978 32630 ugaggngnngagcgcgaaagcgcuc .........<<<<<<....>>>>>> .........((((((....)))))) RNA hairpin structure containing 2-MeImpG monomer analogue and 2-MeImp-oligomer analogue; RNA (25-MER) 5uyk A 1539 3.9 RF00177,RF01959,RF01960 URS000080DDC0_83333 28538735 0003735 0005840 83333 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<.<<....>>.>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>..<<.<<<<<......<<<<<<<<<<.......>>>>>>>>.>>.......>>>>>....>>.<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>.>..........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<.....>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((.((............))..)))))..)))))......(((.......((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..(((.......((((....))))......)))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....))))))).............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... 70S ribosome bound with cognate ternary complex not base-paired to A site codon (Structure I); 16S ribosomal RNA 5uyk 01 2903 3.9 RF02540,RF02541 URS0000BC4674_83333 28538735 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugucgaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<....<.<<<<<<<<<<<<<.<<<....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>..>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<<.....>>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<.........>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<............>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>.>........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<<.<<....>>..>>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>...>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<.........>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......((((.(((((.((.(((...(((((......)))))[[......(((.....]])))...)))...)).))))).))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((((..)))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...).)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((((((.......)))).))...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(.(.........).)..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((.(......).))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((...(((...(((....)))...)))...)))..(((((........)))))]](((((((((((((...((((....((((..(((..(((((((((((....{{{...))))))((..((((...(((((.((((((.((.....)))))))).)..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((...((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.(...............(..(............((((((......))))))...................)..)......).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). 70S ribosome bound with cognate ternary complex not base-paired to A site codon (Structure I); 23S ribosomal RNA 5uyk 02 120 3.9 RF00001 URS00008116C5_83333 28538735 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). 70S ribosome bound with cognate ternary complex not base-paired to A site codon (Structure I); 5S ribosomal RNA 5uyk X 77 3.9 RF00005 URS000041AF00_83333 28538735 0030533 0006412 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((.(.........).)).(((((.......))))).....(((((.......)))))))))))..... 70S ribosome bound with cognate ternary complex not base-paired to A site codon (Structure I); tRNAfMet 5uyk V 20 3.9 28538735 83333 aggagguaaaaauguucaaa .................... .................... 70S ribosome bound with cognate ternary complex not base-paired to A site codon (Structure I); mRNA 5uyk W 77 3.9 RF00005 URS000041AF00_83333 28538735 0030533 0006412 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(((((.......)))))))))))..... 70S ribosome bound with cognate ternary complex not base-paired to A site codon (Structure I); tRNAfMet 5uyk Y 76 3.9 RF00005 URS00005AA258_83333 28538735 0030533 0006412 83333 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).(((((.......))))).....(((((..]....)))))))))))).... 70S ribosome bound with cognate ternary complex not base-paired to A site codon (Structure I); tRNAPhe 5uyl A 1539 3.6 RF00177,RF01959,RF01960 URS000080DDC0_83333 28538735 0003735 0005840 83333 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<.<<....>>.>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>..<<.<<<<<........<<<<<<<<.......>>>>>>>>..........>>>>>....>>.<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<.<.<<<......>>>.....>>>>>>>>.>..........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<..<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>.........>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((...(....)...))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..(......))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....))))))).............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... 70S ribosome bound with cognate ternary complex base-paired to A site codon (Structure II); 16S ribosomal RNA 5uyl 01 2903 3.6 RF02540,RF02541 URS0000BC4674_83333 28538735 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugucgaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<....<.<<<<<<<<<<<<<.<<<....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>..>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<<<<..>>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<<.....>>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<.........>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<............>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>.>........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<<.<<....>>..>>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<..<<.......<<<<<<<<....>>>>>>>>....>>............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......((((.((((((((.(((...(((((......)))))[[......(((.....]])))...)))...)))))))).))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((((..)))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...).)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((((((.......)))).))...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((.(......).))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((...(((...(((....)))...)))...)))..(((((........)))))]](((((((((((((...((((....((((..(((..(((((((((((....{{{...))))))((..(((....((((((((((((.((.....))))))))))..))))..[.)))...))(..(.(((....))).)...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((...((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..(((.((((.(((.((......((((.((((((..(((((.(((.(((((.((((((((((..((((............(..(............((..((......))..))...................)..)...))))..))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....))..))))))).)))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). 70S ribosome bound with cognate ternary complex base-paired to A site codon (Structure II); 23S ribosomal RNA 5uyl 02 120 3.6 RF00001 URS00008116C5_83333 28538735 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). 70S ribosome bound with cognate ternary complex base-paired to A site codon (Structure II); 5S ribosomal RNA 5uyl X 77 3.6 RF00005 URS000041AF00_83333 28538735 0030533 0006412 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((.(.........).)).(((((.......))))).....(((((.......)))))))))))..... 70S ribosome bound with cognate ternary complex base-paired to A site codon (Structure II); tRNAfMet 5uyl V 18 3.6 28538735 83333 aggagguaaaaauguuca .................. .................. 70S ribosome bound with cognate ternary complex base-paired to A site codon (Structure II); mRNA 5uyl W 77 3.6 RF00005 URS000041AF00_83333 28538735 0030533 0006412 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... 70S ribosome bound with cognate ternary complex base-paired to A site codon (Structure II); tRNAfMet 5uyl Y 76 3.6 RF00005 URS00005AA258_83333 28538735 0030533 0006412 83333 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..))))((((((.......))))).)...(((((..]....)))))))))))).... 70S ribosome bound with cognate ternary complex base-paired to A site codon (Structure II); tRNAPhe 5uym A 1539 3.2 RF00177,RF01959,RF01960 URS000080DDC0_83333 28538735 0003735 0005840 83333 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<.<<....>>.>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<.......<<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((...(....)...))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..(......))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....))))))).............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... 70S ribosome bound with cognate ternary complex base-paired to A site codon, closed 30S (Structure III); 16S ribosomal RNA 5uym 01 2903 3.2 RF02540,RF02541 URS0000BC4674_83333 28538735 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugucgaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<<.....>>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<.........>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<............>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>.>........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<<.<<....>>..>>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>...>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......((((((((((.((.(((...(((((......)))))[[......(((.....]])))...)))...)).))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((((..)))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((((((.....))))).))...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(.(.........).)..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((..(......)..)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..(((((((((((....{{{...))))))((..((((...(((((.((((((.((.....)))))))).)..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((....(((....])))....)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((.(............(..(............(((..(......)..)))...................)..)...).)).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). 70S ribosome bound with cognate ternary complex base-paired to A site codon, closed 30S (Structure III); 23S ribosomal RNA 5uym 02 120 3.2 RF00001 URS00008116C5_83333 28538735 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). 70S ribosome bound with cognate ternary complex base-paired to A site codon, closed 30S (Structure III); 5S ribosomal RNA 5uym X 77 3.2 RF00005 URS000041AF00_83333 28538735 0030533 0006412 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((.(.........).)).(((((.......))))).....(((((.......)))))))))))..... 70S ribosome bound with cognate ternary complex base-paired to A site codon, closed 30S (Structure III); tRNAfMet 5uym V 18 3.2 28538735 83333 aggagguaaaaauguuca .................. .................. 70S ribosome bound with cognate ternary complex base-paired to A site codon, closed 30S (Structure III); mRNA 5uym W 77 3.2 RF00005 URS000041AF00_83333 28538735 0030533 0006412 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(((((.......)))))))))))..... 70S ribosome bound with cognate ternary complex base-paired to A site codon, closed 30S (Structure III); tRNAfMet 5uym Y 76 3.2 RF00005 URS00005AA258_83333 28538735 0030533 0006412 83333 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..))))((((((.......))))).)...(((((..]....)))))))))))).... 70S ribosome bound with cognate ternary complex base-paired to A site codon, closed 30S (Structure III); Phe-tRNAPhe 5uyn A 1539 4.0 RF00177,RF01959,RF01960 URS000080DDC0_83333 28538735 0003735 0005840 83333 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<.<<....>>.>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<......>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<.<<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>.....<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>.......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((.((...(....)...))..)))))..)))))......(((.......((((((..((...(((((((.(.((.....((((.(....).))))......)).).....(((....)))....((((((..(......))))))).)))))))..)).)))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......(((.((.....)).)))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((....(...((((.........))))...).))))))......{...((((((..(((((.((((((.....)))))).)))))...((..]])).....)))))))))).(.(......((((....))))....).)...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((..(((((((....))))))).............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....))))))))..)).)))))))).(...((((((......(((..((...(((....)))...))....)))......))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... 70S ribosome bound with near-cognate ternary complex not base-paired to A site codon (Structure I-nc); 16S ribosomal RNA 5uyn 01 2903 4.0 RF02540,RF02541 URS0000BC4674_83333 28538735 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugucgaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<....<.<<<<<<<<<<<<<.<<<...<<<<.<.....>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>..>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<<<<..>>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<<.....>>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<.........>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<............>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>...<<<<........>>>>.))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>.>........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<<.<<....>>..>>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<<<<<...........<<<<<<<<....>>>>>>>>..................>>>>>...>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<....<<<...<<<<<<<<<<.)))..>>>>>..>>>>>...>>>..>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<.........>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((.(((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......((((.(((((.((.(((...(((((......)))))[[......(((.....]])))...)))...)).))))).))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((((..)))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..(((.......))).....)))))))))))))..((.(...((((((.....(((((((.((.((((...((((((......))))))...).)))...(((.(((((........))))))))..).).))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((((((.......)))).))...)))).)))..)).).....)))))).)))..)))))))).)...((((.((((........)))).))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(.(.........).)..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((...(......)...))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((...(((...(((....)))...)))...)))..(((((........)))))]](((((((((((((...((((....((((..(((..(((((((((((....{{{...))))))((..((((...(((((.((((((.((.....)))))))).)..))))..[))))...))(...((((....))))....))))))...)))...)))).........))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((...((.........))...(((((((.....(((....))).......))))))).}((((.(((..((.((((..(((........(((((..((....))...)))))........)))))))...)))))(((((.........)))))........((.(......).(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((((((((..((..............((.(...(........(((..(......)..))).....).............).)).....))..))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).)))))).)). 70S ribosome bound with near-cognate ternary complex not base-paired to A site codon (Structure I-nc); 23S ribosomal RNA 5uyn 02 120 4.0 RF00001 URS00008116C5_83333 28538735 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.....<.<<<<<<<<...>>>>>>>>...>...>>...>>>>>>>>>>. ((((((((((.....((.(((((....(((((((...(.....)...))))..)))...)))))..)).((.......((((((((...)))))))).......))...)))))))))). 70S ribosome bound with near-cognate ternary complex not base-paired to A site codon (Structure I-nc); 5S ribosomal RNA 5uyn X 77 4.0 RF00005 URS000041AF00_83333 28538735 0030533 0006412 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((.(......[..).)).(((((.......))))).....(((((..]....)))))))))))..... 70S ribosome bound with near-cognate ternary complex not base-paired to A site codon (Structure I-nc); tRNAfMet 5uyn V 17 4.0 28538735 83333 aggagguaaaaaugaga ................. ................. 70S ribosome bound with near-cognate ternary complex not base-paired to A site codon (Structure I-nc); mRNA 5uyn W 77 4.0 RF00005 URS000041AF00_83333 28538735 0030533 0006412 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... 70S ribosome bound with near-cognate ternary complex not base-paired to A site codon (Structure I-nc); tRNAfMet 5uyn Y 76 4.0 RF00005 URS000042DDAB_83333 28538735 0030533 0006412 83333 gggucguuagcucaguugguagagcaguugacunuuaaucaauuggucgcagguucgaauccugcacgacccacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).(((((.......))))).....(((((..]....)))))))))))).... 70S ribosome bound with near-cognate ternary complex not base-paired to A site codon (Structure I-nc); tRNALys 5uyp A 1539 3.9 RF00177,RF01959,RF01960 URS000080DDC0_83333 28538735 0003735 0005840 83333 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<.........>.>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<.<<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<<....>.>>>>>>>>..>.......>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((.((............))..)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..(......))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(.(((((.((((((((((......(((.((.....)).)))....))))))))..))))))).)..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((.((((((.....)))))).)))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((..(((((((....)))))))....(....)...))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....))))))))..)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.(((...((....))..)))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... 70S ribosome bound with near-cognate ternary complex base-paired to A site codon, open 30S (Structure II-nc); 16S ribosomal RNA 5uyp 01 2903 3.9 RF02540,RF02541 URS0000BC4674_83333 28538735 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugucgaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<........>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<<..>>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<<.....>>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<.........>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<............>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>.>........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<..<<....>>...>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>...>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......((((.((((((((.(((...(((((......)))))[[......(((.....]])))...)))...)))))))).))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...).)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((((((.......)))).))...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(.(.........).)..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((..(......)..)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((...(((...(((....)))...)))...)))..(((((........)))))]](((((((((((((...((((....((((..(((..(((((((((((....{{{...))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((...((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((((((((..(..(.(.........((..(............(((.((......)).)))...................)..))).)..)..))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....((.((((.((..]]]]..)))))).)).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....(((.((((..((....(((((....)))))...))...))))..))).....))..).))))))))). 70S ribosome bound with near-cognate ternary complex base-paired to A site codon, open 30S (Structure II-nc); 23S ribosomal RNA 5uyp 02 120 3.9 RF00001 URS00008116C5_83333 28538735 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((.(.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((.(((((...))))).)).......))...).)))))))). 70S ribosome bound with near-cognate ternary complex base-paired to A site codon, open 30S (Structure II-nc); 5S ribosomal RNA 5uyp X 77 3.9 RF00005 URS000041AF00_83333 28538735 0030533 0006412 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((.(......[..).)).(((((.......))))).....(((((..]....)))))))))))..... 70S ribosome bound with near-cognate ternary complex base-paired to A site codon, open 30S (Structure II-nc); tRNAfMet 5uyp V 19 3.9 28538735 83333 aggagguaaaaaugagaaa ................... ................... 70S ribosome bound with near-cognate ternary complex base-paired to A site codon, open 30S (Structure II-nc); mRNA 5uyp W 77 3.9 RF00005 URS000041AF00_83333 28538735 0030533 0006412 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(((((.......)))))))))))..... 70S ribosome bound with near-cognate ternary complex base-paired to A site codon, open 30S (Structure II-nc); tRNAfMet 5uyp Y 76 3.9 RF00005 URS000042DDAB_83333 28538735 0030533 0006412 83333 gggucguuagcucaguugguagagcaguugacunuuaaucaauuggucgcagguucgaauccugcacgacccacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..))))..((((.......))))......(((((..]....)))))))))))).... 70S ribosome bound with near-cognate ternary complex base-paired to A site codon, open 30S (Structure II-nc); tRNALys 5uyq A 1539 3.8 RF00177,RF01959,RF01960 URS000080DDC0_83333 28538735 0003735 0005840 83333 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<.......>>.>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<......>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>...>>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>..<<.<<<<<......<.<<<<<<<<.......>>>>>>>>..>.......>>>>>....>>.<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>.>..........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((.(............).).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((........))))......)).).....(((....)))....((((((..(......))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((.(((....)))....))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(..(.((((((((.......)))))))).)...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(.(((((.((((((((((......((((((.....))))))....))))))))..))))))).)..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((.((((((((.....)))))))).)))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...((((((....)))))).....(....)...))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... 70S ribosome bound with near-cognate ternary complex base-paired to A site codon, closed 30S (Structure III-nc); 16S ribosomal RNA 5uyq 01 2903 3.8 RF02540,RF02541 URS0000BC4674_83333 28538735 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugucgaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<.<...<<<.<<<<...<<<<<<.......>>>>.>>...>>>>.>>>..>..>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<.........>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<.<.<<<...<<<....>>>...>>>..>>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>.>........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<<.<<....>>..>>>>>>.>.....>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<<<<<...........<<<<<<<<....>>>>>>>>..................>>>>>...>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>.(<<...<<<<<<<...<<<<<<.......>>>>>>.....<<)..(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. (.((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).((((((((...........)))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......((((.(((((.((.(((....((.(......).)).[[......(((.....]])))...)))...)).))))).))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...).)))...(((.(((((........))))))))..).))))))))).(.((.......))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((((((.......)))).))...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..((((.......))))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((.(......).))))))....))))))(((((((...(((......((((((((....))))))))...)))..))))).)).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..(((((((((((....{{{...))))))((...(((...((((((((((((.((.....))))))))))..))))..[)))....))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((....(((....])))....)))...))))))(...).......(((((((((...((.........))....((((((.....(((....))).......))))))..}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..(((.((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((...(..........((.(...........((.(.((......)).).))..................).)).)...)).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(((((((....))).))))....))..))))))).)))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))).). 70S ribosome bound with near-cognate ternary complex base-paired to A site codon, closed 30S (Structure III-nc); 23S ribosomal RNA 5uyq 02 120 3.8 RF00001 URS00008116C5_83333 28538735 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.....<.<<<<<<<<...>>>>>>>>...>...>>...>>>>>>>>>>. ((((((((.(.....((((((.(....(((((((.............))))..)))...).)))).)).((.......((((((((...)))))))).......))...).)))))))). 70S ribosome bound with near-cognate ternary complex base-paired to A site codon, closed 30S (Structure III-nc); 5S ribosomal RNA 5uyq X 77 3.8 RF00005 URS000041AF00_83333 28538735 0030533 0006412 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((.(......[..).)).(((((.......))))).....(((((..]....)))))))))))..... 70S ribosome bound with near-cognate ternary complex base-paired to A site codon, closed 30S (Structure III-nc); tRNAfMet 5uyq V 18 3.8 28538735 83333 aggagguaaaaaugagaa .................. .................. 70S ribosome bound with near-cognate ternary complex base-paired to A site codon, closed 30S (Structure III-nc); mRNA 5uyq W 77 3.8 RF00005 URS000041AF00_83333 28538735 0030533 0006412 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... 70S ribosome bound with near-cognate ternary complex base-paired to A site codon, closed 30S (Structure III-nc); tRNAfMet 5uyq Y 76 3.8 RF00005 URS000042DDAB_83333 28538735 0030533 0006412 83333 gggucguuagcucaguugguagagcaguugacunuuaaucaauuggucgcagguucgaauccugcacgacccacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).(((((.......))))).....(((((..]....)))))))))))).... 70S ribosome bound with near-cognate ternary complex base-paired to A site codon, closed 30S (Structure III-nc); tRNALys 5uz6 A 25 2.1 URS0000CBFF4C_32630 29411978 32630 gaggugnngagcgcgaaagcgcucg .......<<<<<<<....>>>>>>> .......(((((((....))))))) RNA hairpin structure containing 2-MeImp-oligo analogue; RNA (25-MER) 5uz6 C 25 2.1 URS0000CBFF4C_32630 29411978 32630 gaggugnngagcgcgaaagcgcucg .......<<<<<<<....>>>>>>> .......(((((((....))))))) RNA hairpin structure containing 2-MeImp-oligo analogue; RNA (25-MER) 5uz6 E 25 2.1 URS0000CBFF4C_32630 29411978 32630 gaggugnngagcgcgaaagcgcucg .......<<<<<<<....>>>>>>> .......(((((((....))))))) RNA hairpin structure containing 2-MeImp-oligo analogue; RNA (25-MER) 5v0h A 15 1.9 29411978 32630 nnnnacuuaagucgg ............... ............... RNA duplex with 2-MeImpG analogue bound-one binding site; RNA (5'-R(*(LCC)P*(LCC)P*(LCC)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*GP*G)-3') 5v0h B 15 1.9 29411978 32630 nnnnacuuaagucgg ............... ............... RNA duplex with 2-MeImpG analogue bound-one binding site; RNA (5'-R(*(LCC)P*(LCC)P*(LCC)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*GP*G)-3') 5v0j A 14 1.5 URS0002681414_32630 29411978 32630 nnnnacuuaagucu .............. .............. RNA duplex with 2-MeImpG analogue bound-2 binding sites; RNA (5'-R(*(LCC)P*(LCC)P*(LCA)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*U)-3') 5v0j B 14 1.5 URS0002681414_32630 29411978 32630 nnnnacuuaagucu .............. .............. RNA duplex with 2-MeImpG analogue bound-2 binding sites; RNA (5'-R(*(LCC)P*(LCC)P*(LCA)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*U)-3') 5v0k A 13 1.6 32630 nnnnacuuaaguc ............. ............. RNA duplex with 2-MeImpG analogue bound-3 binding sites; RNA (5'-R(*(LCC)P*(LCC)P*(LCC)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*C)-3') 5v0o A 25 2.7 URS0000CBFF46_32630 29411978 32630 ugaggugnngagcgcgaaagcgcuc .........<<<<<<....>>>>>> .........((((((....)))))) RNA hairpin structure containing 2-MeImpG analogue bound; RNA (25-MER) 5v1k A 12 1.18 URS0000BC466D_32630 28570818 32630 cgcgaannagcg ............ ............ Structure of R-GNA dodecamer; RNA (5'-R(*CP*GP*CP*GP*AP*AP*(5BU)P*(8RJ)P*AP*GP*CP*G)-3') 5v1k B 12 1.18 URS0000BC466D_32630 28570818 32630 cgcgaannagcg ............ ............ Structure of R-GNA dodecamer; RNA (5'-R(*CP*GP*CP*GP*AP*AP*(5BU)P*(8RJ)P*AP*GP*CP*G)-3') 5v1l A 12 1.2 URS0000BC466D_32630 28570818 32630 cgcgaaunagcg ............ ............ Structure of S-GNA dodecamer; RNA (5'-R(*CP*GP*CP*GP*AP*AP*UP*(ZTH)P*AP*GP*CP*G)-3') 5v1l B 12 1.2 URS0000BC466D_32630 28570818 32630 cgcgaaunagcg ............ ............ Structure of S-GNA dodecamer; RNA (5'-R(*CP*GP*CP*GP*AP*AP*UP*(ZTH)P*AP*GP*CP*G)-3') 5v1l C 12 1.2 URS0000BC466D_32630 28570818 32630 cgcgaaunagcg ............ ............ Structure of S-GNA dodecamer; RNA (5'-R(*CP*GP*CP*GP*AP*AP*UP*(ZTH)P*AP*GP*CP*G)-3') 5v1l D 12 1.2 URS0000BC466D_32630 28570818 32630 cgcgaaunagcg ............ ............ Structure of S-GNA dodecamer; RNA (5'-R(*CP*GP*CP*GP*AP*AP*UP*(ZTH)P*AP*GP*CP*G)-3') 5v2r A 15 NA URS0000BC46AC_32630 28700212 32630 ccagaaacggaugga ............... ............... Structure of a GA Rich 8x8 Nucleotide RNA Internal Loop; RNA (5'-R(*CP*CP*AP*GP*AP*AP*AP*CP*GP*GP*AP*UP*GP*GP*A)-3') 5v2r B 15 NA URS0000BC46AC_32630 28700212 32630 ccagaaacggaugga ............... ............... Structure of a GA Rich 8x8 Nucleotide RNA Internal Loop; RNA (5'-R(*CP*CP*AP*GP*AP*AP*AP*CP*GP*GP*AP*UP*GP*GP*A)-3') 5v3f A 31 1.7 URS0000BC4667_32630 28553947 32630 gugcgaagggacggugcggagaggagagcac <<<<.......................>>>> ((((.......................)))) Co-crystal structure of the fluorogenic RNA Mango; RNA (31-MER) 5v3f B 19 1.7 URS0000BC4667_32630 28553947 32630 gggacggugcggagaggag ................... ................... Co-crystal structure of the fluorogenic RNA Mango; RNA (31-MER) 5v7q A 3118 3.7 RF02540,RF02541,RF00002 URS00005E0FC6_1773 28977617 0003735 0005840 1773 aagugucuaagggcgcaugguggaugccuuggcaucgagagccgaugaaggacgugggaggcugcgauaugccucggggagcugucaaccgagcguggauccgaggauuuccgaauggggaaacccagcacgagugaugucgugcuacccgcaucugaauauauagggugcgggagggaacgcggggaagugaaacaucucaguacccguaggaggagaaaacaauugugauuccgcaaguaguggcgagcgaacgcggaacaggcuaaaccgcacgcauggguaaccggguagggguugugugugcgggguugugggaggauaugucucagcgcuacccggcugagaggcagucagaaagugucgugguuagcggaaguggccugggauggucugccguagacggugagagcccgguacgcgaaaacccggcaccugccuaguaucaauucccgaguagcagcgggcccguggaauccgcugugaauccgccgggaccacccgguaagccuaaauacuccucgaugaccgauagcggauuaguaccgugagggaauggugaaaaguaccccgggaggggagugaaagaguaccugaaaccgugugccuacaauccgucagagccuccuuuuccucuccggaggaggguggugauggcgugccuuuugaagaaugagccugcgagucagggacaugucgcaagguuaacccgugugggguagccgcagcgaaagcgagucugaauagggcgacccacacgcgcauacgcgcgugugaauaguggcguguucuggacccgaagcggagugaucuacccauggccagggugaagcgcggguaagaccgcguggaggcccgaacccacuuagguugaagacugaggggaugagcuguggguaggggugaaaggccaaucaaacuccgugauagcugguucuccccgaaaugcauuuaggugcagcguugcgugguucaccgcggagguagagcuacuggauggccgauggguuacugacgucagccaaacuccgaaugccgugguguaaagcguggcagugagacggcgggggauaagcuccguacgucgaaagggaaacagcccagaucgccggcuaaggcccccaagcgugugcuaagugggaaaggaugugcagucgcaaagacaaccaggagguuggcuuagaagcagccacccuugaaagagugcguaauagcucacuggucaagugauugugcgccgauaauguagcggggcucaagcacaccgccgaagccgcggcacauccaccuugugguggguguggguaggggagcgucccucauucagcgaagccaccgggugaccggugguggagggugggggagugagaaugcaggcaugaguagcgacaaggcaagugagaaccuugcccgccgaaagaccaaggguuccugggccaggccaguccgcccagggugagucgggaccuaaggcgaggccgacaggcguagucgauggacaacggguugauauucccguacccgugugugggcgcccgugacgaaucagcgguacuaaccacccaaaaccggaucgaucacuccccuucggggguguggaguucuggggcugcgugggaacuucgcugguaguagucaagcgaaggggugacgcaggaagguagccguaccagucagugguaacacuggggcaagccgguagggagagcgauaggcaaauccgucgcucacuaauccugagaggugacgcauagccgguugaggcgaauucggugauccucugcugccaagaaaagccucuagcgagcacacacacggcccguaccccaaaccgacacagguggucagguagagcauaccaaggcguacgagauaacuaugguuaaggaacucggcaaaaugcccccguaacuucgggagaagggggaccggaauaucgugaacacccuugcggugggagcgggauccggucgcagaaaccagugaggagcgacuguuuacuaaaaacacagguccgugcgaagucgcaagacgauguauacggacugacgccugcccggugcuggaagguuaagaggacccguuaacccgcaagggugaagcggagaauuuaagccccaguaaacggcggugguaacuauaaccauccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaacgacuucucaacugucucaaccauagacucggcgaaauugcacuacgaguaaagaugcucguuacgcgcggcaggacgaaaagaccccgggaccuucacuacaacuugguauugauguucgguacgguuuguguaggauaggugggagacugugaaaccucgacgccaguuggggcggagucguuguugaaauaccacucugaucguauugggcaucuaaccucgaacccugaaucggguuuagggacagugccuggcggguaguuuaacuggggcgguugccuccuaaaauguaacggaggcgcccaaagguucccucaaccuggacggcaaucagguggcgaguguaaaugcacaagggagcuugacugcgagacuuacaagucaagcagggacgaaagucgggauuagugauccggcacccccgaguggaaggggugucgcucaacggauaaaagguaccccggggauaacaggcugaucuuccccaagaguccauaucgacgggaugguuuggcaccucgaugucggcucgucgcauccuggggcuggagcaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguuuagaacgucgugagacaguucggucucuauccgccgcgcgcgucagaaacuugaggaaaccugucccuaguacgagaggaccgggacggacgaaccucuggugcaccaguugucccgccaggggcaccgcuggauagccacguucggucaggauaaccgcugaaagcaucuaagcgggaaaccuucuccaagaucagguuucucacccacuuggugggauaaggccccccgcagaacacggguucaauaggucagaccuggaagcucaguaauggguguagggaacuggugcuaaccggccgaaaacuu <<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<<......<<<<<<.[[.(((.>>>.....<<<<<<<..<<<)))..]].>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>..<<<<<<<<.........>>>>>>.>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<....<<<<<<<<<<......<<((((((.>>..>>>>>>>>>>......<<<<<<<<...<<<<<<<.)))))).>>>>>>><<<<<.......<<<<<..<<<<.<<<.....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>.>>>>>>>>>>....>>>..>>>>>.....<<<<<<<<.........>>>>>>>>.......<.<<..((((>>.>...>>>......>>.>>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<..<<<.<<<<<.<<.....>>..>>>>>.>>>..>>>>...<.<........>.>.<<<<<<....<<..<<<<<.<<<<..<<<...<<<<..>>>>...>>>...<<....>>..<<<.......>>>.....<<<<<<<<....>>>>>>>>.....>>>>.>>>>>.>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<....<<<<<<........<<....<<<.<<<<...............>>>>.>>>..>>.........>>>>>>....>>>>>>>.>>..<<<<<<<<<<......>>>>>>.>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<..<<...<<...........>>...>>.........<<......>>....>>>>....>>>>>>>>>.>>...........)))......>>>>>>.>>>...>>>>>>><<<<<<<<<<....>>>>>>>>>>....>>>>>><<<<<<<<<<<.......<<<<<<<<....>>>>>>>>....>>>>>>>>>.>>.....>>>>>><......<<.....<<<<<.........>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((.<<<.<<...<<<...<<<....>>>...>>>...>>....<<<<........>>>>.))<<<<<<<<<.<<.....<<<<...<<<<<<<......<<<<.<<...<<<<<.<..<<<<.<<<<....>>>>.>>>>.>.>>>>>...>>.>>>>.....>>>>>>>.....>>>>.<<..<<<<<<...<<<<..<<<..<<<<..<<<<<....[[[...>>>>>.<<..<<<....<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>....>>>...>>...<<........>>.....>>>>...>>>...>>>>........>>>>>>.>>..>>.>>>>>>>>>>>>...>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<...<<.<...<<<<.....>>>.>....>.>>>>>>>>............<<<<<<<<<..<<...........>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<...<<<<<<..<<<..<<<....<<<<..<<<<....>>>>...>>>>....>>>..>>>>>>>>..>.>>>.<<<<<.......>>>>>.........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.((..<<<<<......))>>>>>..<<<<<<<<.<<<.<<......<<<<<.<<<<..<<<<...<<.<<<<<.<<<<<<<<<<<<<<..............................<<<............>>>............................>>>>>>>>>>>>>>...<<<.<<<<<........>>>>>>>>....>>>>>.>>....>>>.>.<<.........>><<<<<<...........>>>>>>..<<...<.<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>.>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>...>>>>>.......<<<<.....<<<<.................>>>>......>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>>>>>>>>>....<<<<<<<...<<<...<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]].>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>..>>>.......>>>>>>>..<<<<<...>>>>>....<<<<.<<<<.......>>>>.....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>> (((.......(((((((.((.....(((..(((((((((((((......(((((..[[.[.[..)).....((((((...(((].]..]].)))......))))))...)))....(((....)))(((((((......)))))))..((((((((.........))))))).).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...(((....(((((((((.......(([[[[[[))....)))))))))....(.((((.((.....((((((.]]]]]].)))))).((((........((((((.((((.(((...(.((((......)))))[[(...).(((.....]])))...)))...)))))))))).)))).....))...))))......((((((...[.......)))))).....)....((].[[[[)).....)))......)).))))))).))...............((....))....)).........((((....)))).............).....)).))))))).....(.((((....(.((.((.((.....))..)).)).)....)))).<.(.(........).).((((((....(((.((((((.(((...((...(((....)))...)).....(....)...(((.......))).....((((((((....)))))))).....))).)))))))))..((.(...((((((.....((((..((((..(((....(((((......)))))....)[))....(((.((.((........)).)))))..).)))..)))).(.(((.....)))...)..))))))......).))..(((((.....(((((....)))))((((((((.......((((((.....(((....(((.((((....(.()..)....)))).)))..)).).....)))))).......)))))).))..((((.(((.(......).)))..))))....(((......)))...((((.(((...((([[[.....((((((.....(.....((..((.(((((((.....{.((((...(...(.............)...)......(...((......)).)..))))...))))))).)).))...........]]].)....)))))).)))...)))))))((((((((((....)))))))))).....)))))(.(((((((((.......((((((((....))))))))....)))))))))..).....))))))(......((.....((((((.......))))))((((....(((...((...((((((...((.....)).))))))....[[((((.((...(((....((....))....)))...))...(.(((........))).)]](((((((((.((.....((((....((((((.(....((((.((...(((((....((((.((((....)))).))))...)))))...)).))))....)))))))......)))).((...(((((...(((...(((..((((..(((((....{{{...))))).((..(((.....((((((((((.((.....))))))))).....)))...[.)))...))...((........)).....))))...)))....)))(..)....)))))..))..)).)))))))))))))..)).....((......))..))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((....(.....((((....]))))......)..))))))(...).......((((.(((..].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(.(((((..(((...((....(((...((((....))))....)))....))...))))))))...)))).((((.........)))).........((..........(((((.......)))))..)..)....))))....).)).)))).)..))).)))))))).)))))).....))[[..(((((.....>]])))))..((((((((.(((.((......(((((.(.((..((.....((.(((((.((((..(((((((((..............................(....(....)....)............................)))))))))..))))...(((.(((((........))))))))....))))).))......))..((.......[.))((((((..........]))))))([((...(.(((((...(((((.........))))).....((][.[[[))....))))).)...((((..(((...{..)))..)))).(((....))).))]]].].....((.((((.((..]]]]..)))))).)).....)}......)).)...)))))......((((..(.(.((((...((.......))...)))).)...).)).).)......((((.((((((..((.(((((........)))))...))..((((.....))))......)))))..)...))).).....((..(((....)))...))....))..)))))))))))[...(((((((...(((...(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....)))..)))..]....)))))))..((((.....))))....((((.((((.......)))).....((((((((.(((....(((((....)))))...)))..))))).)))...)))).....))) Cryo-EM structure of the large ribosomal subunit from Mycobacterium tuberculosis bound with a potent linezolid analog; 23S rRNA 5v7q B 115 3.7 RF00001 URS00005330B1_1773 28977617 0003735 0005840 1773 uuacggcggccacagcggcagggaaacgcccggucccauuccgaacccggaagcuaagccugccagcgccgaugauacugccccuccggguggaaaaguaggacaccgccgaaca .<.<<<<<<.....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<........<<<<<....>>>>>........>>...>>>>>>.>.. ...((((((.....((((((((.....((((((...(.....)...))))..))....)))))).)).((.......((((((....)))))).......))...)))))).... Cryo-EM structure of the large ribosomal subunit from Mycobacterium tuberculosis bound with a potent linezolid analog; 5S ribosomal RNA 5v8i 1A 2862 3.25 RF02540,RF02541,RF00002 URS0000D56C2F_262724 0003735 0005840 262724 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgucuaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcucaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaaaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagcuccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagacgacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>....>>>>>>>>>..>>>....<<<..>>>......>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<......>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((..(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((.(.((((((......)))).)))..)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....)))))))))....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((.((((((.(......[..(((((..(((......(((((.((....)).)))))...)))..........].)))))).)))))).)))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..((((.))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Thermus thermophilus 70S ribosome lacking ribosomal protein uS17; 23S Ribosomal RNA 5v8i 1B 118 3.25 RF00001 URS000080DFF2_262724 0003735 0005840 262724 ccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>.. (((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).))))))))).. Thermus thermophilus 70S ribosome lacking ribosomal protein uS17; 5S Ribosomal RNA 5v8i 1a 1500 3.25 RF00177,RF01959,RF01960 URS0000D56C32_262724 0003735 0005840 262724 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgaggaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<......>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((..)))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((...(((((((....)))))))...((((....))))...)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.... Thermus thermophilus 70S ribosome lacking ribosomal protein uS17; 16S Ribosomal RNA 5v8i 2A 2858 3.25 RF02540,RF02541,RF00002 URS0000D56C2F_262724 0003735 0005840 262724 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgucuaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcucaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaaaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagcuccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagacgacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..<<<.......>>>...>>>.......<............>.>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<.......<<<<<<<....>>>>>>>....>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...((((((((.....))))))))....{.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).))))....(((((((((.[.....)))))))))....}.(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))..(......)..)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...((((((((.(.((((((......)))).)))..))))))))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((........((((.((...(((.......)))....)).........((......))...))))....)))))))))).))..........]]].)....))))))))))...)))))))(((((((())))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....)))))))))....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((.(.((((.(.........(((((..(((........(((..........))).....)))............)))))).)))).).)))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))((.(.).).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Thermus thermophilus 70S ribosome lacking ribosomal protein uS17; 23S Ribosomal RNA 5v8i 2B 118 3.25 RF00001 URS000080DFF2_262724 0003735 0005840 262724 ccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>.. (((((.(((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).))).))))).. Thermus thermophilus 70S ribosome lacking ribosomal protein uS17; 5S Ribosomal RNA 5v8i 2a 1504 3.25 RF00177,RF01959,RF01960 URS0000D56C32_262724 0003735 0005840 262724 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgaggaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>....<<......>>...>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((((((....))))))).(...((....))...).)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Thermus thermophilus 70S ribosome lacking ribosomal protein uS17; 16S Ribosomal RNA 5v93 A 3118 4.0 RF02540,RF02541,RF00002 URS00005E0FC6_1773 28977617 0003735 0005840 1773 aagugucuaagggcgcaugguggaugccuuggcaucgagagccgaugaaggacgugggaggcugcgauaugccucggggagcugucaaccgagcguggauccgaggauuuccgaauggggaaacccagcacgagugaugucgugcuacccgcaucugaauauauagggugcgggagggaacgcggggaagugaaacaucucaguacccguaggaggagaaaacaauugugauuccgcaaguaguggcgagcgaacgcggaacaggcuaaaccgcacgcauggguaaccggguagggguugugugugcgggguugugggaggauaugucucagcgcuacccggcugagaggcagucagaaagugucgugguuagcggaaguggccugggauggucugccguagacggugagagcccgguacgcgaaaacccggcaccugccuaguaucaauucccgaguagcagcgggcccguggaauccgcugugaauccgccgggaccacccgguaagccuaaauacuccucgaugaccgauagcggauuaguaccgugagggaauggugaaaaguaccccgggaggggagugaaagaguaccugaaaccgugugccuacaauccgucagagccuccuuuuccucuccggaggaggguggugauggcgugccuuuugaagaaugagccugcgagucagggacaugucgcaagguuaacccgugugggguagccgcagcgaaagcgagucugaauagggcgacccacacgcgcauacgcgcgugugaauaguggcguguucuggacccgaagcggagugaucuacccauggccagggugaagcgcggguaagaccgcguggaggcccgaacccacuuagguugaagacugaggggaugagcuguggguaggggugaaaggccaaucaaacuccgugauagcugguucuccccgaaaugcauuuaggugcagcguugcgugguucaccgcggagguagagcuacuggauggccgauggguuacugacgucagccaaacuccgaaugccgugguguaaagcguggcagugagacggcgggggauaagcuccguacgucgaaagggaaacagcccagaucgccggcuaaggcccccaagcgugugcuaagugggaaaggaugugcagucgcaaagacaaccaggagguuggcuuagaagcagccacccuugaaagagugcguaauagcucacuggucaagugauugugcgccgauaauguagcggggcucaagcacaccgccgaagccgcggcacauccaccuugugguggguguggguaggggagcgucccucauucagcgaagccaccgggugaccggugguggagggugggggagugagaaugcaggcaugaguagcgacaaggcaagugagaaccuugcccgccgaaagaccaaggguuccugggccaggccaguccgcccagggugagucgggaccuaaggcgaggccgacaggcguagucgauggacaacggguugauauucccguacccgugugugggcgcccgugacgaaucagcgguacuaaccacccaaaaccggaucgaucacuccccuucggggguguggaguucuggggcugcgugggaacuucgcugguaguagucaagcgaaggggugacgcaggaagguagccguaccagucagugguaacacuggggcaagccgguagggagagcgauaggcaaauccgucgcucacuaauccugagaggugacgcauagccgguugaggcgaauucggugauccucugcugccaagaaaagccucuagcgagcacacacacggcccguaccccaaaccgacacagguggucagguagagcauaccaaggcguacgagauaacuaugguuaaggaacucggcaaaaugcccccguaacuucgggagaagggggaccggaauaucgugaacacccuugcggugggagcgggauccggucgcagaaaccagugaggagcgacuguuuacuaaaaacacagguccgugcgaagucgcaagacgauguauacggacugacgccugcccggugcuggaagguuaagaggacccguuaacccgcaagggugaagcggagaauuuaagccccaguaaacggcggugguaacuauaaccauccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaacgacuucucaacugucucaaccauagacucggcgaaauugcacuacgaguaaagaugcucguuacgcgcggcaggacgaaaagaccccgggaccuucacuacaacuugguauugauguucgguacgguuuguguaggauaggugggagacugugaaaccucgacgccaguuggggcggagucguuguugaaauaccacucugaucguauugggcaucuaaccucgaacccugaaucggguuuagggacagugccuggcggguaguuuaacuggggcgguugccuccuaaaauguaacggaggcgcccaaagguucccucaaccuggacggcaaucagguggcgaguguaaaugcacaagggagcuugacugcgagacuuacaagucaagcagggacgaaagucgggauuagugauccggcacccccgaguggaaggggugucgcucaacggauaaaagguaccccggggauaacaggcugaucuuccccaagaguccauaucgacgggaugguuuggcaccucgaugucggcucgucgcauccuggggcuggagcaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguuuagaacgucgugagacaguucggucucuauccgccgcgcgcgucagaaacuugaggaaaccugucccuaguacgagaggaccgggacggacgaaccucuggugcaccaguugucccgccaggggcaccgcuggauagccacguucggucaggauaaccgcugaaagcaucuaagcgggaaaccuucuccaagaucagguuucucacccacuuggugggauaaggccccccgcagaacacggguucaauaggucagaccuggaagcucaguaauggguguagggaacuggugcuaaccggccgaaaacuu <<<<......<<<<<<<<<<<.....<<...<<<<<<<<<<<<......<<<<<<.((.((..>>>.....<<<<<<<..<<<.))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<<..>>>..<<<<<<.....<<.....>>....>>>>>>..<<<....<<<<<<<<<<......<<((((((>>...>>>>>>>>>>......<<<<<<<<<..<<<<<<<.)))))).>>>>>>><<<<........<<<<<..<<<<.<<<.....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>.>>>>>.>>>>...>>>>..>>>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..>>>......>>.>>>>>>>.>................<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<..<<<.<<<<<.<.......>..>>>>>.>>>..>>>>.....<........>...<<<<<<....<<<.<<<<<<<<<<..<<<...<<<<..>>>>...>>>...<<....>>..<<<<.....>>>>......<<<<<<<....>>>>>>>......>>>>>>>>>>>>>..<<....<.<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>....>....>>..<<<<<<....<<<<<....>>>>><<<<<<<<<....<<<<<<<.......<<....<<<.<<<<...............>>>>.>>>..>>........>>>>>>>....>>>>>>>.>>..<<<<<<<<<<......>>>>>>.>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<..<...<<...........>>...>..........<<......>>...>>>>>....>>>>>>>>>.>>...........)))......>>>>>>.>>>...>>>>>>><<<<<<<<<<....>>>>>>>>>>....>>>>>><<<<<<<<<<<.......<<<<<<<<....>>>>>>>>....>>>>>>>>>.>>.....>>>>>><......<<.....<<<<<.........>>>>><<<<....<<<<<.<<...<<<<<<.............>>>>>>....((.<<<.<.<..<<....<<<....>>>....>>...>>....<<<<........>>>>.))<<<<<<<<<.<<.....<<<<...<<<<<<<.<....<<<<.<<...<<<<<.<..<<<<.<<<<<..>>>>>.>>>>.>.>>>>>...>>.>>>>....>>>>>>>>.....>>>>.<<...<<<<<...<<.<..<<<..<<<<..<<<<<...((((...>>>>>.<...<<<....<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>....>>>....>...<<........>>.....>>>>...>>>....>>>........>>>>.>.>>..>>.>>>>>>>>>>>>...>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<..................<<<<<.....<..>......>>>>><<<<<<...<<.<....<<<.....>>>......>.>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<....<<<<..<<<<....>>>>...>>>>....>>...>>>>>>>>..>>>>><<<<<.........>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>........>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.<<......<<<<<.<<<<..<.<<....<.<<<<<.<<<<<<<<<<<<<.<.............................<<..............>>...........................>.>>>>>>>>>>>>>...<<<.<<<<<........>>>>>>>>....>>>>>.>.....>>..>..<..........><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>..<<....>>..>>)))]......<<<<<<<.<<..>>>>..>>>>>>>>>.............>>>>...>>>>>.......<<<<.<.<.<<<<...<<.......>>...>>>>.>...>>>>.>.......<.<<<...<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>.......>>>..>....<<<<<<<....>>>.>>>>....>>..>>>>>>>>>>>....<<<<<<<...<<<...<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))))>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>..>>>.......>>>>>>>..<<<<<...>>>>>....<<<<..<<<.......>>>.......<<<<<<..<<<....<<<<<....>>>>>...>>>...>>>>.>>....>>>>....>>>> .((.......(((((((.((.....(.(..((((((.(.((((......(((((..[[.[.[..)).....((((((...(((].]..]].)))......))))))...)))....(((....)))(((((((......))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....(..]....)....)))))...(((....(((((((((.......(.[[[[[[.)....)))))))))....(.((((...(....((((((.]]]]]].)))))).(((((.......((((((..(((.(((...(.((((......)))))[[.......((.....]]))....)))...))).)))))))))))....).....))))......(((.((...[.......)).))).....).(((((].[[[[)))))..)))......))..).)))).))...............((....))....)..........((((....)))).............).....)).))))))).....(.((((..(...((.((.((.....))..)).))...)..)))).[.(.(........).).((((((....(((.(((.((((((...((...((((..))))...))....((....))..(((.......)))......(((((((....)))))))......)))))).))))))..((.....((((((.....((((..((((.(((.....(((((......))))).....[)))...(((.(((((........))))))))..).)))..)))).(.(((.....)))...)..))))))........))..(((((.....(((((....)))))((.((((((......((..((......((....(((.((((...............)))).)))..)).......))..))......))))))..))..((((.(((((......)))))..))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((.(((((.(.....{.(((((..(.....................)......(...((......)).).)))))...).))))).)).))...........]]].)....))))))))))...)))))))((((((((((....)))))))))).....)))))((((((((((((......((((((((....))))))))...)))))))))).)).....))))))(......((.....(((((.........)))))((((....((((..((...((((((...(.......).))))))....[[((((.((...(.(...(((....)))...).)...))...(.(((........))).)]]((((((((..((.....((((....((((((......((((.((...(((((.(..((((.((((....)))).)))).).)))))...)).)))).....))))))......)))).((...(((((...(((...(((..((((..(((((....{{....))))).((..(((....(((((((((((.((.....))))))))).....))))..[.)))...))...(..........).....))))...)))....)))(..)....)))))..))..))..))))))))))))..)).....((......)).)))).(((.......)))..))))..((((....(((((((......(....(.......(((((....(.{..).....)))))((((((....(.....(.((....])).)......)..))))))(...)........(((((....].((.........))...(((((((.....(((....))).......))))))).}((((.((...(...(((..(((...((....((((..((((....))))...))))....))...)))))).....).))(((((.........)))))........((..........(((((.......)))))..)..)....)))).......)))))...).)....))))))).)))))).....))....(((((.....]..)))))..((((((((.(((.((......(((((.(.((..(((....((.((....((((((((..(((((...................(..........(...(......)...).......)....................)))))..))))))))...(((.(((((........)))))))).......)).)).....)).).((.......[.))((((((..........]))))))([((...(.(((((...(((((.........))))).....((][.[[[))....))))).)...((((..(((...{..)))..)))).(((....))).))]]].].....((.((((.((..]]]]..)))))).)).....)}......)).)...)))))......((((..(.(.((((...((.......))...)))).)...).)).).)......((((...((((..((((((((........)))))..))).(((((.....))))).....)))).......))).).....(((((((....))).))))....))..)))))))))))[...(((((((....((...(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))..)))))...)))).)))).)..(((......((.....}.......))......)))..))...]....)))))))..((((.....))))....(((..((((.......))))......((..(((.(((....(((((....)))))...)))..)))...)).....))).....)). Cryo-EM structure of the 70S ribosome from Mycobacterium tuberculosis bound with Capreomycin; 23S rRNA 5v93 B 115 4.0 RF00001 URS00005330B1_1773 28977617 0003735 0005840 1773 uuacggcggccacagcggcagggaaacgcccggucccauuccgaacccggaagcuaagccugccagcgccgaugauacugccccuccggguggaaaaguaggacaccgccgaaca .<.<<<<<<.....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<...<....<<<<<....>>>>>......>.>>...>>>>>>.>.. ...((((((.....((((((((....(((((((...(.....)...))))..))...))))))).)).((.......((((((....)))))).......))...)))))).... Cryo-EM structure of the 70S ribosome from Mycobacterium tuberculosis bound with Capreomycin; 5S rRNA 5v93 a 1519 4.0 RF00177,RF01959,RF01960 URS00002C0A67_1773 28977617 0003735 0005840 1773 uggagaguuugauccuggcucaggacgaacgcuggcggcgugcuuaacacaugcaagucgaacggaaaggucucuucggagauacucgaguggcgaacgggugaguaacacgugggugaucugcccugcacuucgggauaagccugggaaacugggucuaauaccggauaggaccacgggaugcaugucuugugguggaaagcgcuuuagcggugugggaugagcccgcggccuaucagcuuguugguggggugacggccuaccaaggcgacgacggguagccggccugagaggguguccggccacacugggacugagauacggcccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagcgacgccgcgugggggaugacggccuucggguuguaaaccucuuucaccaucgacgaagguccggguucucucggauugacgguagguggagaagaagcaccggccaacuacgugccagcagccgcgguaauacguagggugcgagcguuguccggaauuacugggcguaaagagcucguaggugguuugucgcguuguucgugaaaucucacggcuuaacugugagcgugcgggcgauacgggcagacuagaguacugcaggggagacuggaauuccugguguagcgguggaaugcgcagauaucaggaggaacaccgguggcgaaggcgggucucugggcaguaacugacgcugaggagcgaaagcguggggagcgaacaggauuagauacccugguaguccacgccguaaacgguggguacuagguguggguuuccuuccuugggauccgugccguagcuaacgcauuaaguaccccgccuggggaguacggccgcaaggcuaaaacucaaaggaauugacgggggcccgcacaagcggcggagcauguggauuaauucgaugcaacgcgaagaaccuuaccuggguuugacaugcacaggacgcgucuagagauaggcguucccuuguggccugugugcagguggugcauggcugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuugucucauguugccagcacguaaugguggggacucgugagagacugccggggucaacucggaggaagguggggaugacgucaagucaucaugccccuuauguccagggcuucacacaugcuacaauggccgguacaaagggcugcgaugccgcgagguuaagcgaauccuuaaaagccggucucaguucggaucggggucugcaacucgaccccgugaagucggagucgcuaguaaucgcagaucagcaacgcugcggugaauacguucccgggccuuguacacaccgcccgucacgucaugaaagucgguaacacccgaagccaguggccuaacccucgggagggagcugucgaaggugggaucggcgauugggacgaagucguaacaagguagccguaccggaaggugcggcuggauc ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<......<<<.<<<..<<<..<<.<..<<..<<<....>>>...>>>..>>>>>......<<........<<<<<<<..<<...<<<<<<<.<<<<.....<<<<........>>>>......>>>>.....<<<<<<<<<<....>>>>>>>>>>.....<<......>>.>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<...<<<<<<....>>>>.>>>>...>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<.....<<.<<...........>>.>>.......>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<.....<<<<<<<.....>>>>>>>...>>>>>>>..>>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<<..<<<......>>>.....>>>>>>>>.>..........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<.......>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).].<<<<.<<<<<<<.<<..<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<.......<.<<....<<<.<.<....>.>.>>>..............>>.>..<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<..<<<<<<....<...<<<......>>>.>.....>>>>>>.....<<<<<.....>>>>>.........>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>.....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>.....<..<<.<.<<<<.<<<..<<<<<<..<<<<....<.<<<...<<<..<<....>>.>>>..>>>.>...>>>>..>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... ....((((....[[[..)))).((((.(((((..(((((..((....(((.(((..(((..((.((..(..(((....)))...)))..)))))......(((.......(((((((..((...(((.(((...((.....(((.((....)).)))......))........((((.((((....)))).))))......((......)).))).)))..))))))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.((.....((((....))))...))).)...)))))..((((..(...((((....))))...).))))...(.(((((......(....((.....))....)........)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))...........(([[...(.((((....((.(((((((.((..((((((.....(((((.(.....).)))))...))))))....)))))))))....(((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))))).))....))....))))....((((((...((...((((.........))))...))))))))..........((((((..((.((((.((((.......)))).)))).))...((..]])).....)))))))))..(((......((((....))))....)))...]]]..(.(((.(((((((.((..((.((..((((((((((.......(........)...........(((((((..(.......(.(..(((.(.(....).).)))...........)..)....).((.((....(((((..(....(((((((((....)))...(((......)))...)))))).....((((.((((..(...((..(((......)))))....)..))))..(..(((((.....))))).....)..)))).....)...)))...))..))))....)))))))...)).)))))))).(...(((((((.....(((..((....((....))....))....))).....)))))))......(....(((((((........)))))))....)..)..)).)).....(((((((..........)))))))......))...))))))))))..)..(.(.....(.((((.(((..((((((..((((....(.((((..(((..((....)).))).)))).)...))))..))))))..))).))))..)......)..)..(((((.(((....))).)))))..... Cryo-EM structure of the 70S ribosome from Mycobacterium tuberculosis bound with Capreomycin; 16S rRNA 5v9z A 25 2.51 URS0000CBFF46_32630 29411978 32630 ugaggugnngagcgcgaaagcgcuc .........<<<<<<....>>>>>> .........((((((....)))))) RNA hairpin structure containing 2-MeImpG analogue bound; RNA (25-MER) 5vcf A 22 2.8 URS0000CBFF24_32630 29411978 32630 cugcuggcuaaggcccgaaagg ..............<<....>> ..............((....)) RNA hairpin structure containing tetraloop/receptor motif, complexed with 2-MeImpG analogue; RNA (5'-R(*CP*UP*GP*CP*UP*GP*GP*CP*UP*AP*AP*GP*GP*CP*CP*CP*GP*AP*AP*AP*GP*G)-3') 5vcf B 12 2.8 URS0000CBFF20_32630 29411978 32630 cuaugccugcug ............ ............ RNA hairpin structure containing tetraloop/receptor motif, complexed with 2-MeImpG analogue; RNA (5'-R(*CP*UP*AP*UP*GP*CP*CP*UP*GP*CP*UP*G)-3') 5vci A 22 2.6 URS0000CBFF24_32630 29411978 32630 cugcuggcuaaggcccgaaagg ..............<<....>> ..............((....)) RNA hairpin structure containing tetraloop/receptor motif, complexed with 2-MeImpG analogue; RNA (5'-R(*CP*UP*GP*CP*UP*GP*GP*CP*UP*AP*AP*GP*GP*CP*CP*CP*GP*AP*AP*AP*GP*G)-3') 5vci B 12 2.6 URS0000CBFF20_32630 29411978 32630 cuaugccugcug ............ ............ RNA hairpin structure containing tetraloop/receptor motif, complexed with 2-MeImpG analogue; RNA (5'-R(P*CP*UP*AP*UP*GP*CP*CP*UP*GP*CP*UP*G)-3') 5vgw A 22 2.42 URS0000CBFF24_32630 29411978 32630 cugcuggcuaaggcccgaaagg ..............<<....>> ..............((....)) RNA hairpin structure containing tetraloop/receptor motif; RNA (5'-R(*CP*UP*GP*CP*UP*GP*GP*CP*UP*AP*AP*GP*GP*CP*CP*CP*GP*AP*AP*AP*GP*G)-3') 5vgw B 13 2.42 URS0000CBFF3F_32630 29411978 32630 gcuaugccugcug ............. ............. RNA hairpin structure containing tetraloop/receptor motif; RNA (5'-R(P*GP*CP*UP*AP*UP*GP*CP*CP*UP*GP*CP*UP*G)-3') 5vh7 A 15 NA URS0000BC4673_9606 28617590 9606 gaccagcagcagguc ............... ............... Structure and dynamics of RNA repeat expansions that cause Huntington's Disease and myotonic dystrophy type 1; RNA (5'-R(*GP*AP*CP*CP*AP*GP*CP*AP*G)-3') 5vh7 B 15 NA URS0000BC4673_9606 28617590 9606 gaccagcagcagguc ............... ............... Structure and dynamics of RNA repeat expansions that cause Huntington's Disease and myotonic dystrophy type 1; RNA (5'-R(*GP*AP*CP*CP*AP*GP*CP*AP*G)-3') 5vh8 A 15 NA URS0000BC4675_9606 28617590 9606 gaccugcugcugguc ............... ............... Structure and dynamics of RNA repeat expansions that cause Huntington's Disease and myotonic dystrophy type 1; RNA (5'-R(*GP*AP*CP*CP*UP*GP*CP*UP*GP*CP*UP*GP*GP*UP*C)-3') 5vh8 B 15 NA URS0000BC4675_9606 28617590 9606 gaccugcugcugguc ............... ............... Structure and dynamics of RNA repeat expansions that cause Huntington's Disease and myotonic dystrophy type 1; RNA (5'-R(*GP*AP*CP*CP*UP*GP*CP*UP*GP*CP*UP*GP*GP*UP*C)-3') 5vj9 A 16 1.57 URS0000BC467C_287 28600356 287 gcggggacgacccugc <<<<<<....>>>>>> ((((((....)))))) Guanidine-II riboswitch P2 hairpin dimer from Pseudomonas aeruginosa; RNA (5'-R(*GP*CP*GP*GP*GP*GP*AP*CP*GP*AP*CP*CP*CP*UP*GP*C)-3') 5vj9 B 16 1.57 URS0000BC467C_287 28600356 287 gcggggacgacccugc <<<<<<....>>>>>> ((((((....)))))) Guanidine-II riboswitch P2 hairpin dimer from Pseudomonas aeruginosa; RNA (5'-R(*GP*CP*GP*GP*GP*GP*AP*CP*GP*AP*CP*CP*CP*UP*GP*C)-3') 5vj9 C 16 1.57 URS0000BC467C_287 28600356 287 gcggggacgacccugc <<<<<<....>>>>>> ((((((....)))))) Guanidine-II riboswitch P2 hairpin dimer from Pseudomonas aeruginosa; RNA (5'-R(*GP*CP*GP*GP*GP*GP*AP*CP*GP*AP*CP*CP*CP*UP*GP*C)-3') 5vj9 D 16 1.57 URS0000BC467C_287 28600356 287 gcggggacgacccugc <<<<<<....>>>>>> ((((((....)))))) Guanidine-II riboswitch P2 hairpin dimer from Pseudomonas aeruginosa; RNA (5'-R(*GP*CP*GP*GP*GP*GP*AP*CP*GP*AP*CP*CP*CP*UP*GP*C)-3') 5vjb A 16 2.1 URS0000BC467C_287 28600356 287 gcggggacgacccngc <<<<<<....>>>>>> ((((((....)))))) Guanidine-II riboswitch P2 hairpin dimer with 5-bromoU substitution from Pseudomonas aeruginosa; RNA (5'-R(*GP*CP*GP*GP*GP*GP*AP*CP*GP*AP*CP*CP*CP*(5BU)P*GP*C)-3') 5vjb B 16 2.1 URS0000BC467C_287 28600356 287 gcggggacgacccngc <<<<<<....>>>>>> ((((((....)))))) Guanidine-II riboswitch P2 hairpin dimer with 5-bromoU substitution from Pseudomonas aeruginosa; RNA (5'-R(*GP*CP*GP*GP*GP*GP*AP*CP*GP*AP*CP*CP*CP*(5BU)P*GP*C)-3') 5vjb C 16 2.1 URS0000BC467C_287 28600356 287 gcggggacgacccngc <<<<<<....>>>>>> ((((((....)))))) Guanidine-II riboswitch P2 hairpin dimer with 5-bromoU substitution from Pseudomonas aeruginosa; RNA (5'-R(*GP*CP*GP*GP*GP*GP*AP*CP*GP*AP*CP*CP*CP*(5BU)P*GP*C)-3') 5vjb D 16 2.1 URS0000BC467C_287 28600356 287 gcggggacgacccngc <<<<<<....>>>>>> ((((((....)))))) Guanidine-II riboswitch P2 hairpin dimer with 5-bromoU substitution from Pseudomonas aeruginosa; RNA (5'-R(*GP*CP*GP*GP*GP*GP*AP*CP*GP*AP*CP*CP*CP*(5BU)P*GP*C)-3') 5vp2 1A 2871 2.8 RF02540,RF02541,RF00002 URS00001698E8_300852 28505372 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu 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(((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)..)))))).)))]....((((((((..[......))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((....(((.(......).)..))...)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((..((.........))...))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((.((((((((.(.........(((((..(((......((((((((....))))))))...)))............)))))).)))))))).)))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..(((...)))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with madumycin II and bound to mRNA and A-, P- and E-site tRNAs at 2.8A resolution; 23S Ribosomal RNA 5vp2 1B 120 2.8 RF00001 URS000080DEE8_300852 28505372 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the Thermus thermophilus 70S ribosome in complex with madumycin II and bound to mRNA and A-, P- and E-site tRNAs at 2.8A resolution; 5S ribosomal RNA 5vp2 1a 1500 2.8 RF00177,RF01959,RF01960 URS000080DFED_300852 28505372 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<...<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>....<<<<.<<<<<....>>>>>.>>>>...<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>...>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>.<..<<......>>.>..>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((((((....))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((..((((....))))..))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((.(((....))).)))....((......))....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the Thermus thermophilus 70S ribosome in complex with madumycin II and bound to mRNA and A-, P- and E-site tRNAs at 2.8A resolution; 16S ribosomal RNA 5vp2 1v 13 2.8 28505372 10665 aaaaauguucuaa ............. ............. Crystal structure of the Thermus thermophilus 70S ribosome in complex with madumycin II and bound to mRNA and A-, P- and E-site tRNAs at 2.8A resolution; mRNA 5vp2 1w 72 2.8 RF00005 URS00005AA258_562 28505372 0030533 0006412 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcac <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.. (((((((..((((...[..)))).((((.........)))).....(((((..]....)))))))))))).. Crystal structure of the Thermus thermophilus 70S ribosome in complex with madumycin II and bound to mRNA and A-, P- and E-site tRNAs at 2.8A resolution; A-site and E-site tRNAs 5vp2 1x 76 2.8 RF00005 URS000041AF00_562 28505372 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with madumycin II and bound to mRNA and A-, P- and E-site tRNAs at 2.8A resolution; P-site tRNA 5vp2 1y 74 2.8 RF00005 URS00005AA258_562 28505372 0030533 0006412 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[..)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with madumycin II and bound to mRNA and A-, P- and E-site tRNAs at 2.8A resolution; A-site and E-site tRNAs 5vp2 2A 2800 2.8 RF02540,RF02541,RF00002 URS00001698E8_300852 28505372 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu 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(((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...((((((((.....))))))))....{.(((((((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).))))....(((((((((.[.....)))))))))....}.(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....(())....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.(((......((..........)).......))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((.().)))))))).))..........]]].)....))))))))))...)))))))(((((((..)))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.((...{{....))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........(((((...((.......((((.((....)).))))....)).............)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..((((((((........)))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....))))))).((...)).....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))....))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with madumycin II and bound to mRNA and A-, P- and E-site tRNAs at 2.8A resolution; 23S Ribosomal RNA 5vp2 2B 120 2.8 RF00001 URS000080DEE8_300852 28505372 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>>. ..(((((((((....((((((.(....(((((((...(.....)...))))..)))...).)))).))(((.......((((((((....)))))))).......))).))))))))).. Crystal structure of the Thermus thermophilus 70S ribosome in complex with madumycin II and bound to mRNA and A-, P- and E-site tRNAs at 2.8A resolution; 5S ribosomal RNA 5vp2 2a 1503 2.8 RF00177,RF01959,RF01960 URS000080DFED_300852 28505372 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggau .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<.<<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<......>>....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>.........<.<<<<<<<........>>>>>>>>.........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((.(....).)))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((((((....)))))))....(.(....).)....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..(.((....)).)..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}... Crystal structure of the Thermus thermophilus 70S ribosome in complex with madumycin II and bound to mRNA and A-, P- and E-site tRNAs at 2.8A resolution; 16S ribosomal RNA 5vp2 2v 13 2.8 28505372 10665 aaaaauguucuaa ............. ............. Crystal structure of the Thermus thermophilus 70S ribosome in complex with madumycin II and bound to mRNA and A-, P- and E-site tRNAs at 2.8A resolution; mRNA 5vp2 2w 69 2.8 RF00005 URS00005AA258_562 28505372 0030533 0006412 562 cccgganagcucagggagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggca <<<<<<..<<<<.....>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>.. ((((((..((((...[.)))).((((.........))))......((((..]....)))).)))))).. Crystal structure of the Thermus thermophilus 70S ribosome in complex with madumycin II and bound to mRNA and A-, P- and E-site tRNAs at 2.8A resolution; A-site and E-site tRNAs 5vp2 2x 76 2.8 RF00005 URS000041AF00_562 28505372 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with madumycin II and bound to mRNA and A-, P- and E-site tRNAs at 2.8A resolution; P-site tRNA 5vp2 2y 73 2.8 RF00005 URS00005AA258_562 28505372 0030533 0006412 562 gcccgganagcucagggagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<.....>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[.)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with madumycin II and bound to mRNA and A-, P- and E-site tRNAs at 2.8A resolution; A-site and E-site tRNAs 5vpo QA 1500 3.34 RF00177,RF01959,RF01960 URS000080DFED_300852 30262649 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggggucuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<...>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<.<<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<......>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(.((((((..(((((((....)))))))...((((....))))..)))))).)).((.(((...((((((......(((((((((....)))...(((......)))...)))))).....((((.(((((((...(...(((.....))).)....))))))).....(((((....)))))........)))).......).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. The 70S P-site ASL SufA6 complex; 16S rRNA 5vpo RA 2882 3.34 RF02540,RF02541,RF00002 URS00001698E8_300852 30262649 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>....<<<<<.....<......>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<..>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<<.....>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[[)))...].((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....(())...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((...((((((......)))).))...)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......(((((.(((..(((.........)))..))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........(((((..(((......((((((((....))))))))...)))............)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.((((.....))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) The 70S P-site ASL SufA6 complex; 23S rRNA 5vpo RB 120 3.34 RF00001 URS00005F2F4B_300852 30262649 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> (((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).))))))))))) The 70S P-site ASL SufA6 complex; 5S rRNA 5vpo XA 1500 3.34 RF00177,RF01959,RF01960 URS000080DFED_300852 30262649 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggggacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<...>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<......>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).(((.(...))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((((..(((((((....)))))))...((((....))))..))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.((((((........(((.....))).......))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. The 70S P-site ASL SufA6 complex; 16S rRNA 5vpo YA 2883 3.34 RF02540,RF02541,RF00002 URS00001698E8_300852 30262649 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<..>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<..>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<<.....>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((..)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...((((((((.....))))))))....[.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).))))....(((((((((.{.....)))))))))....].(((((}.[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....(())...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((...((((((......)))).))...)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......(((((.(((..(((.........)))..))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........(((((..(((......((((((((....))))))))...)))............)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.((((.....))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) The 70S P-site ASL SufA6 complex; 23S rRNA 5vpo YB 120 3.34 RF00001 URS00005F2F4B_300852 30262649 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> (((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).))))))))))) The 70S P-site ASL SufA6 complex; 5S rRNA 5vpo XV 18 3.34 URS000080E12A_83333 30262649 83333 cuucguucggngacgaag <<<<<<......>>>>>> ((((((......)))))) The 70S P-site ASL SufA6 complex; P-site ASL SufA6 5vpo QV 18 3.34 URS000080E12A_83333 30262649 83333 cuucguucggngacgaag <<<<<<......>>>>>> ((((((......)))))) The 70S P-site ASL SufA6 complex; P-site ASL SufA6 5vpp RA 2882 3.9 RF02540,RF02541,RF00002 URS00001698E8_300852 30262649 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>....<<<<<.....<......>......>>>>>.....<.....<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<......<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>..>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>....>.>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<..>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..<<<<.......>>>>..>>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<<..>>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<<<<<<<<...<<.......>>...>>>>>>>..>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<.....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[[)))...].((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...((((......((.]...)).....))))...((([...((((((((.....))))))))....(.(((((((((......(...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)..)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....(())...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((.(.((((((......)))).)))..)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......(((((.(((..(((.........)))..))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...(.((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....)).)...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.(((((.....))))).))))))(...).......((((.((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).)).)))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.(((((...(((((.(((.(((((.(((.((((((((((((...........(((((..(((......(((((.((....)).)))))...)))............)))))..)))))))))))).)))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}.......)))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(..................(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))...)))) The 70S P-site tRNA SufA6 complex; 23S rRNA 5vpp RB 120 3.9 RF00001 URS00005F2F4B_300852 30262649 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).)))))))))). The 70S P-site tRNA SufA6 complex; 5S rRNA 5vpp YA 2883 3.9 RF02540,RF02541,RF00002 URS00001698E8_300852 30262649 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<....<<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<..>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>.............>....>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<..>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<<........<.....<<<<<....<<..>>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>.>>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<<.....>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((..)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((.((((.....)))).)))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....(())...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((.(.((((((......)))).)))..)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......(((((.(((..((...........))..))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((.(...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((.(((((((((.((.....))))))))).....)).))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...)....))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((.(((((.((((((.(.........(((((..(((......((((((((....))))))))...)))............)))))).)))))).))))).)))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(..................(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) The 70S P-site tRNA SufA6 complex; 23S rRNA 5vpp YB 120 3.9 RF00001 URS00005F2F4B_300852 30262649 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> (((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).))))))))))) The 70S P-site tRNA SufA6 complex; 5S rRNA 5vpp QA 1511 3.9 RF00177,RF01959,RF01960 URS0000D77904_300852 30262649 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggggucuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgaggaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucaccuccuuu ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<...>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<...<<<<<<......>>>>>.>...>>>>>....<<<<.<<<<<....>>>>>.>>>>...<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<.<<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<....<<<......>>>.......>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<.......<<<<<<<..<<<<<<<....>>>>>>>...<<<......>>>..>>>>>>>..<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.............. ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((.......(((....)))......))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.((((((..((((((((((......((((((.....))))))....))))))))..)).))))))..(((((((((...((((((.(....((((((....((........)).......))))))....).......((....))..))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((....((((.(((((......((........))..........(((((((..(...(((((((...(((((((....)))))))...((((....))))...)))))))).((.(((...((.(((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...(...(((.....)))).....))))))).....(((((....)))))........)))).....).).))....)).)))))....)))))))..[)).))).)))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)....))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}............. The 70S P-site tRNA SufA6 complex; 16S rRNA 5vpp XA 1515 3.9 RF00177,RF01959,RF01960 URS0000D77904_300852 30262649 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgaggaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucaccuccuuu ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<.<.......>.>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>....<<<<.<<<<<....>>>>>.>>>>...<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<.<<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<....<<<......>>>.......>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<......>>>>>>...<<<......>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.............. ....((((..[.[[[..)))).((((.(((((...((((((((....(((.(((..(((..((.(((((((.((.....)).))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((.(...).)).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).)))))...((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((.(((((......((........))........(.(((((((..(...(((.((((..(((((.(....).)))))...((((....))))..)))).)))).((.(((...((.(((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...(...(((.....)))).....))))))).....(((((....)))))........)))).....).).))....)).)))))....)))))))).[)).))).)))).(...((((((......(((..(((.((((....))))).))....)))......))))))......(....((.((((........)))).))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}............. The 70S P-site tRNA SufA6 complex; 16S rRNA 5vpp XX 19 3.9 30262649 32630 ggcaaggagguaaaacccu ................... ................... The 70S P-site tRNA SufA6 complex; messenger RNA 5vpp XV 78 3.9 RF00005 URS0000D7792C_562 30262649 0030533 0006412 562 cggugauuggcgcagccugguagcgcacuucguucggngacgaaggggucggagguucgaauccucuaucaccgacca <<<<<<<..<<<<.........>>>>..<<<<<......>>>>.>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.........))))....((........)).........((((.......)))).))))))).... The 70S P-site tRNA SufA6 complex; P-site tRNA SufA6 5vpp QX 19 3.9 30262649 32630 ggcaaggagguaaaacccu ................... ................... The 70S P-site tRNA SufA6 complex; messenger RNA 5vpp QV 78 3.9 RF00005 URS0000D7792C_562 30262649 0030533 0006412 562 cggugauuggcgcagccugguagcgcacuucguucggngacgaaggggucggagguucgaauccucuaucaccgacca <<<<<<<..<<<<.........>>>>..<<<<<......>>>>.>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.........))))....((........)).........((((.......)))).))))))).... The 70S P-site tRNA SufA6 complex; P-site tRNA SufA6 5vxq A 11 1.002 28973475 32630 aaaaaaaaaaa ........... ........... X-Ray crystallography structure of the parallel stranded duplex formed by 5-rA5-dA-rA5; DNA/RNA (5'-R(*AP*AP*AP*AP*A)-D(P*A)-R(P*AP*AP*AP*AP*A)-3') 5vxq B 11 1.002 28973475 32630 aaaaaaaaaaa ........... ........... X-Ray crystallography structure of the parallel stranded duplex formed by 5-rA5-dA-rA5; DNA/RNA (5'-R(*AP*AP*AP*AP*A)-D(P*A)-R(P*AP*AP*AP*AP*A)-3') 5w0o C 15 2.488 URS0000BC4676_32630 28671666 32630 gcgaagcgcuucgcu ............... ............... Structure of human TUT7 catalytic module (CM) in complex with dsRNA; double-stranded RNA 5w0o D 15 2.488 URS0000BC4676_32630 28671666 32630 gcgaagcgcuucgcu ............... ............... Structure of human TUT7 catalytic module (CM) in complex with dsRNA; double-stranded RNA 5w3v E 10 2.243 URS0000CBFF2D_32630 29044109 32630 aacccgggga .......... .......... Crystal Structure of macaque APOBEC3H in complex with RNA; RNA (5'-R(P*AP*AP*CP*CP*CP*GP*GP*GP*GP*A)-3') 5w3v F 10 2.243 URS0000CBFF26_32630 29044109 32630 aaccccgggc .......... .......... Crystal Structure of macaque APOBEC3H in complex with RNA; RNA (5'-R(P*AP*AP*CP*CP*CP*CP*GP*GP*GP*C)-3') 5w3v G 10 2.243 URS0000CBFF26_32630 29044109 32630 aaccccgggc .......... .......... Crystal Structure of macaque APOBEC3H in complex with RNA; RNA (5'-R(P*AP*AP*CP*CP*CP*CP*GP*GP*GP*C)-3') 5w3v H 10 2.243 URS0000CBFF2D_32630 29044109 32630 aacccgggga .......... .......... Crystal Structure of macaque APOBEC3H in complex with RNA; RNA (5'-R(P*AP*AP*CP*CP*CP*GP*GP*GP*GP*A)-3') 5w4k 1A 2871 2.7 RF02540,RF02541,RF00002 URS00001698E8_300852 28846667 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<....<<<<........>>>..>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..<<......(..>>...>>>.........<<......>>.).>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<.<<....>>.>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<...>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((...((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((.(..(((..........)..)))..)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((..((.........))...))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((.((((((((.(......[..(((((..(((......((((((((....))))))))...)))..........].)))))).)))))))).)))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((...)))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with Klebsazolicin and bound to mRNA and A-, P- and E-site tRNAs at 2.7A resolution; 23S Ribosomal RNA 5w4k 1B 120 2.7 RF00001 URS000080DEE8_300852 28846667 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the Thermus thermophilus 70S ribosome in complex with Klebsazolicin and bound to mRNA and A-, P- and E-site tRNAs at 2.7A resolution; 5S Ribosomal RNA 5w4k 1a 1500 2.7 RF00177,RF01959,RF01960 URS000080DFED_300852 28846667 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<......>>....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((((((....))))))).)))))......(((......((((((((..((...(((((((.(((((.....(((((....)))))......)))))....((((..((((....))))..))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((...(((.(((....))).)))....((......))....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the Thermus thermophilus 70S ribosome in complex with Klebsazolicin and bound to mRNA and A-, P- and E-site tRNAs at 2.7A resolution; 16S Ribosomal RNA 5w4k 1v 13 2.7 28846667 10665 aaaaauguucuaa ............. ............. Crystal structure of the Thermus thermophilus 70S ribosome in complex with Klebsazolicin and bound to mRNA and A-, P- and E-site tRNAs at 2.7A resolution; mRNA 5w4k 1w 74 2.7 RF00005 URS00005AA258_562 28846667 0030533 0006412 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[..)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with Klebsazolicin and bound to mRNA and A-, P- and E-site tRNAs at 2.7A resolution; tRNA, A-site and E-site tRNAs 5w4k 1x 76 2.7 RF00005 URS000041AF00_562 28846667 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with Klebsazolicin and bound to mRNA and A-, P- and E-site tRNAs at 2.7A resolution; P-site tRNA 5w4k 1y 74 2.7 RF00005 URS00005AA258_562 28846667 0030533 0006412 562 gcccgganagcucaggguagagcaggggauugaaaauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((......)))).((((.........)))).....(((((.......)))))))))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with Klebsazolicin and bound to mRNA and A-, P- and E-site tRNAs at 2.7A resolution; tRNA 5w4k 2A 2800 2.7 RF02540,RF02541,RF00002 URS00001698E8_300852 28846667 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<........>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<..>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<...>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....(())....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((.....((..........))......)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((.().)))))))).))..........]]].)....))))))))))...)))))))(((((((())))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(......[..(((((...((.......((((.((....)).))))....))...........].)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(((...)).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with Klebsazolicin and bound to mRNA and A-, P- and E-site tRNAs at 2.7A resolution; 23S Ribosomal RNA 5w4k 2B 120 2.7 RF00001 URS000080DEE8_300852 28846667 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>>. ..(((((((((....((((((.(....(((((((...(.....)...))))..)))...).)))).))(((.......((((((((....)))))))).......))).))))))))).. Crystal structure of the Thermus thermophilus 70S ribosome in complex with Klebsazolicin and bound to mRNA and A-, P- and E-site tRNAs at 2.7A resolution; 5S Ribosomal RNA 5w4k 2a 1503 2.7 RF00177,RF01959,RF01960 URS000080DFED_300852 28846667 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggau .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<......>>....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((((((....)))))))....(.(....).)....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.(.((....)).)).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}... Crystal structure of the Thermus thermophilus 70S ribosome in complex with Klebsazolicin and bound to mRNA and A-, P- and E-site tRNAs at 2.7A resolution; 16S Ribosomal RNA 5w4k 2v 13 2.7 28846667 10665 aaaaauguucuaa ............. ............. Crystal structure of the Thermus thermophilus 70S ribosome in complex with Klebsazolicin and bound to mRNA and A-, P- and E-site tRNAs at 2.7A resolution; mRNA 5w4k 2w 72 2.7 RF00005 URS00005AA258_562 28846667 0030533 0006412 562 cccgganagcucagggagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<..<<<<.....>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((...[.)))).((((.........))))......((((..]....)))).))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with Klebsazolicin and bound to mRNA and A-, P- and E-site tRNAs at 2.7A resolution; tRNA, A-site and E-site tRNAs 5w4k 2x 76 2.7 RF00005 URS000041AF00_562 28846667 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with Klebsazolicin and bound to mRNA and A-, P- and E-site tRNAs at 2.7A resolution; P-site tRNA 5w4k 2y 73 2.7 RF00005 URS00005AA258_562 28846667 0030533 0006412 562 gcccgganagcucagggagagcaggggauugaaaauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<.....>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[.)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with Klebsazolicin and bound to mRNA and A-, P- and E-site tRNAs at 2.7A resolution; tRNA 5wdt A 2900 3.0 RF02540,RF02541 URS00021ED92F_562 29733411 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggaggagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcaugcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaacucaucuccggggguagagcacuguuucggcaagggggucacgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugugaagguguacugugagguaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggcgacuugcucguggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccgggagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacuccuugagaguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu .<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((....<<...............<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>............>>..........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<<..>>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<......<<...<<<.<<<<...<<<<<<<..>>>>>.>>...>>>>.>>>..>>.......>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<...<........<<<<<.......<<.........>>..............<<<......>>>..>>>>>....>...>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<......>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>>.<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>....<<<<......>>>>....>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<<.<<....>>..>>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>...>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>.. .(((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((.(((...(((]]]..].))).......))).))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.(...................(((.(((...(((((......)))))[[......(((.....]])))...)))...)))................)...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((((..)))))))..)))).[.(.(........).).((((((....(((((((((((((..((....((.....))....))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(..(..(..)..)...)...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((...(........(((((.(.......................).....(..(((......)))).)))))....)...))))).))...........]]].)...))))))))))...)))))))((((.(..........).))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..(((....((((..((((((.((.....))))))))....))))....)))...))(..(((........)))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....((....(((.......)))....))...))))))(...).......(((((.(((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((.........((((...(....)....)))).........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).).))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((.(..(((..(....(..........(..(............(((.((......)).)))...................)..).)....)..)))..).)))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..((.((((.....(....)....)))).)).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((.....((((....))))....))...))))).))).....))..).)))))))).. 70S ribosome-EF-Tu H84A complex with GppNHp; 23S rRNA 5wdt B 120 3.0 RF00001 URS00008116C5_562 29733411 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((.(((((.....(((((.((....(((((((...(.....)...))))..)))...)).))).)).((.......((((((((...)))))))).......))...))))).)))). 70S ribosome-EF-Tu H84A complex with GppNHp; 5S rRNA 5wdt a 1540 3.0 RF00177,RF01959,RF01960 URS0000D56C37_562 29733411 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggaucaccuccu ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.....<<.<<<<.<<....>>.>>>>..>>....>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<......>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>..<<.<<<<<......<.<<<<<<<<<....>.>>>>>>>>.>........>>>>>....>>.<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<...<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>......>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<...<<....>>..>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ ........((((..[.[[[..)))).((.(.(((((..(((((((((....(((.(((..(((..((.(......(((............))).....)..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..(......))))))).)))))))..)).)))))))(((....((...((((((((.......)))))))).))......)))..((((((((....))))...))))))).(((((............))))).((.(....).))...)))))).).......(((.....(((....)))...)))..)).))))))..((((......((((....)))).....))))..((.(((((...(....(((..(((......).))..))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))).))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....))))))).............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... 70S ribosome-EF-Tu H84A complex with GppNHp; 16S rRNA 5wdt v 77 3.0 RF00005 URS00001BBAFC_562 29733411 0030533 0006412 562 cgcggggnggagcagccuggnagcucgucgggcucauaacccgaagaucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... 70S ribosome-EF-Tu H84A complex with GppNHp; tRNA-fMet 5wdt w 77 3.0 RF00005 URS00001BBAFC_562 29733411 0030533 0006412 562 cgcggggnggagcagccuggnagcucgucgggcucauaacccgaagaucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ..((..([.((.(.]....[..).))..((((.......))))......(((((..]....))))))..))...... 70S ribosome-EF-Tu H84A complex with GppNHp; tRNA-fMet 5wdt x 12 3.0 29733411 562 acuauguucacg ............ ............ 70S ribosome-EF-Tu H84A complex with GppNHp; mRNA 5wdt y 76 3.0 RF00005 URS00005AA258_562 29733411 0030533 0006412 562 gcccgganagcucagncggnagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..))))(((((.........)))).)...(((((..]....)))))))))))).... 70S ribosome-EF-Tu H84A complex with GppNHp; tRNA-Phe 5we4 A 2900 3.1 RF02540,RF02541 URS00021ED92F_562 29733411 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggaggagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcaugcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaacucaucuccggggguagagcacuguuucggcaagggggucacgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugugaagguguacugugagguaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggcgacuugcucguggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccgggagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacuccuugagaguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu .<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((...<<..........<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>.>>>>>.......>>.........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<<..>>>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<<..>>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<...<........<<<<<.......<<.........>>..............<<<......>>>..>>>>>....>...>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<......>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>>....<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>........<<<<......>>>>....>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<<.<<....>>..>>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>.(<<...<<<<<<<...<<<<<<.......>>>>>>.....<<)..(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>.. .(((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((..(................(((((.(((...(((((......)))))[[......(((.....]])))...)))...))))).............)....)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((.(......).))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(..(..(..)..)...)...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((...(......{..(.((.(.......................).....(..(((......)))).)).).....)...))))).))...........]]].)...))))))))))...)))))))((((((..........))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...(((((.((((((.((.....)))))))).)..))))...))))...))(..(((........)))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....((.....(((.....))).....))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((.(..(((..(....(..........(..(............(((.((......)).)))...................)..).)....)..)))..).)))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((.....((((....))))....))...))))).))).....))..).)))))))).. 70S ribosome-EF-Tu wt complex with GppNHp; 23S rRNA 5we4 B 120 3.1 RF00001 URS00008116C5_562 29733411 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....(((((.((....(((((((...(.....)...))))..)))...)).))).)).((.......((((((((...)))))))).......))...)))))))))). 70S ribosome-EF-Tu wt complex with GppNHp; 5S rRNA 5we4 a 1540 3.1 RF00177,RF01959,RF01960 URS0000D56C37_562 29733411 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggaucaccuccu ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.....<<.<<<<.<<....>>.>>>>..>>....>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<......>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>..<<.<<<<<......<.<<<<<<<<<....>.>>>>>>>>.>........>>>>>....>>.<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<...<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>......>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ ........((((..[.[[[..)))).((.(.(((((..(((((((((....(((.(((..(((..((.(......(((............))).....)..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..(......))))))).)))))))..)).)))))))(((....((...((((((((.......)))))))).))......)))..((((((((....))))...))))))).(((((............))))).((.(....).))...)))))).).....(.(((.....(((....)))...)))).)).))))))..((((......((((....)))).....))))..((.(.(((...(....(((.((((.......)))).))).....)....))).)....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))).))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....))))))).............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... 70S ribosome-EF-Tu wt complex with GppNHp; 16S rRNA 5we4 v 77 3.1 RF00005 URS00001BBAFC_562 29733411 0030533 0006412 562 cgcggggnggagcagccuggnagcucgucgggcucauaacccgaagaucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((.(..((((......[..)))).(((((.......))))).....(((((..]....)))))).))))..... 70S ribosome-EF-Tu wt complex with GppNHp; tRNA-fMet 5we4 w 77 3.1 RF00005 URS00001BBAFC_562 29733411 0030533 0006412 562 cgcggggnggagcagccuggnagcucgucgggcucauaacccgaagaucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>..<<<<.......>>>>......<<<<<.......>>>>>>>>>>>..... ..((.(([.((.(.]....[..).))..(((.........)))......(((((..]....))))))).))...... 70S ribosome-EF-Tu wt complex with GppNHp; tRNA-fMet 5we4 x 12 3.1 29733411 562 acuauguucacg ............ ............ 70S ribosome-EF-Tu wt complex with GppNHp; mRNA 5we4 y 76 3.1 RF00005 URS00005AA258_562 29733411 0030533 0006412 562 gcccgganagcucagncggnagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..))))(((((.........)))).)...(((((..]....)))))))))))).... 70S ribosome-EF-Tu wt complex with GppNHp; Phe-tRNA-Phe 5we6 A 2900 3.4 RF02540,RF02541 URS00021ED92F_562 29733411 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggaggagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcaugcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaacucaucuccggggguagagcacuguuucggcaagggggucacgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugugaagguguacugugagguaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggcgacuugcucguggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccgggagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacuccuugagaguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<.<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<......>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<......>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<...<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>...>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<<<<..>>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<....<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<<..>>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>....>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<...<........<<<<<.......<<.........>>..............<<<......>>>..>>>>>....>...>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<......>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<<.<<....>>..>>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>.(<<...<<<<<<<...<<<<<<.......>>>>>>.....<<)..(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>.>>. ....((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).((((..((...........).).)))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...(((..(............(.......((.(((...(((((......)))))[[......(((.....]])))...)))...)).......).........)........((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((((..)))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.(((....(..(........)...)....))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((...............((((.(.......................).....(..(((......)))).))))...........))).))...........]]].)...))))))))))...)))))))((((((..........))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((........)))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....((....((((....]))))....))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((..(((..((...(.............(...(........(((.((......)).))).....).............)....)...))..)))..)))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).)))))..... 70S ribosome-EF-Tu H84A complex with GTP and cognate tRNA; 23S rRNA 5we6 B 120 3.4 RF00001 URS00008116C5_562 29733411 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). 70S ribosome-EF-Tu H84A complex with GTP and cognate tRNA; 5S rRNA 5we6 a 1539 3.4 RF00177,RF01959,RF01960 URS000080DDC0_562 29733411 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<.........<<.<<<<.<<....>>.>>>>..>>......>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<.<<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>..<<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>>.<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..(......(.((.(............).).).).....))))......(((......(((((((..((...(((((((...((.....(((((......)))))......)).......(((....)))....((((((..(......))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((.....(((....)))...)))).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((((.......)))))))).....)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.((((((..((((((((((......((((((.....))))))....))))))))..)).))))))..(((((((((...((((((.(....(((((((...((........))......)))))))....).......((....))..))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((......(((((((..(((((((....))))))).............))))).))..((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((.(.(..((((...((..(((.....)))))....))))..)..(..(((((.....))))).....)..).)).....).).)))...)).)))))....))))))))..)).)))))))).(...(((.(((.....(((..((...(((....)))...))....))).....))).)))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... 70S ribosome-EF-Tu H84A complex with GTP and cognate tRNA; 16S rRNA 5we6 v 77 3.4 RF00005 URS00001BBAFC_562 29733411 0030533 0006412 562 cgcggggnggagcagccuggnagcucgucgggcucauaacccgaagaucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(((((.......)))))))))))..... 70S ribosome-EF-Tu H84A complex with GTP and cognate tRNA; tRNA-fMet 5we6 w 77 3.4 RF00005 URS00001BBAFC_562 29733411 0030533 0006412 562 cgcggggnggagcagccuggnagcucgucgggcucauaacccgaagaucgucggnucaaauccggcccccgcaacca .<.<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>.>..... .(.((((..((.(......[..).))..((((.......))))......(((((..]....))))))))).)..... 70S ribosome-EF-Tu H84A complex with GTP and cognate tRNA; tRNA-fMet 5we6 x 12 3.4 29733411 562 acuauguucacg ............ ............ 70S ribosome-EF-Tu H84A complex with GTP and cognate tRNA; mRNA 5we6 y 76 3.4 RF00005 URS00005AA258_562 29733411 0030533 0006412 562 gcccgganagcucagncggnagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..))))(((((.........)))).)...(((((..]....)))))))))))).... 70S ribosome-EF-Tu H84A complex with GTP and cognate tRNA; Phe-tRNA-Phe 5wf0 A 2900 3.6 RF02540,RF02541 URS00021ED92F_562 29733411 0003735 0005840 562 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.<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<.<..>.>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>...[.....<......>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<.......<<<....<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>....>>>....>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))....].]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<<..>>>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<<..>>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<...<........<<<<<.......<<.........>>..............<<<......>>>..>>>>>....>...>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<......>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>>...<<<<<....>>>>>....>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<<.<<....>>..>>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>.. ..((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((.(((...(((]]]..].))).......))).))...)))....(((....)))(((((.(....).))))).(((((((.(.........).))))))).))...((((((.....(...[..)......))))).)....................(((((.....((.]...))....)))))...((((.(............(....(((((.(((...(((((......)))))[[......(((.....]])))...)))...)))))....).........)...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((((..)))))))..)))).[.(.(........).).((((((....(((((((((((((..((....((.....))....))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((.(......).))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(..(..(..)..)...)...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((...(........(((((.(.......................).....(..(((......)))).)))))....)...))))).))...........]]].)...))))))))))...)))))))((((.(..........).))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..(((....(((((.((((((.((.....)))))))).)..))))....)))...))(..(((........)))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....((....(((((..).))))....))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((.(..(((..((...(..........(..(............(((.((......)).)))...................)..).)...))..)))..).)))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).)))))))... 70S ribosome-EF-Tu H84A complex with GTP and near-cognate tRNA (Complex C2); 23S rRNA 5wf0 B 120 3.6 RF00001 URS00008116C5_562 29733411 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. (.((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))).). 70S ribosome-EF-Tu H84A complex with GTP and near-cognate tRNA (Complex C2); 5S rRNA 5wf0 a 1540 3.6 RF00177,RF01959,RF01960 URS0000D56C37_562 29733411 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggaucaccuccu ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.....<<.<<<<.<<....>>.>>>>..>>....>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<......>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<......<<.)))>>........>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<.......<<<....>>>.....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.((...(.(..((.(......(((............))).....)..))).)......(((......(((((((..((...(.(((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..(......))))))).))))).)..)).)))))))(((....((...((((((((.......)))))))).))......)))..((((((((....))))...))))))).(((((............))))).((.(....).))....))))).).......(((...((.((....).)).))))..)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((((.......)))))))).....)....)))))....)....(.([[[...(((.......((.]]])).........))).))....)))))))))..........((([[...(.((((...(((.(((((((.((.((((((.......((((((.....)))))).....))))))...)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((.(((((.....))))).))))))...((..]])).....)))))))))).(((.......(((....))).....)))...]]].](((((..((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((..(((((((....))))))).............))))).))).((.((....((((((.(....(((((((((....)))...(.(......).)...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...))..))))....))))))))..)).)))))))).(........((.....(((..((...(((....)))...))....))).....))...........(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))).))).))..(.(..((.(..(((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).)))...).))...)..)..(((((((((....)))))))))}........... 70S ribosome-EF-Tu H84A complex with GTP and near-cognate tRNA (Complex C2); 16S rRNA 5wf0 v 77 3.6 RF00005 URS00001BBAFC_562 29733411 0030533 0006412 562 cgcggggnggagcagccuggnagcucgucgggcucauaacccgaagaucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... 70S ribosome-EF-Tu H84A complex with GTP and near-cognate tRNA (Complex C2); tRNA-fMet 5wf0 w 77 3.6 RF00005 URS00001BBAFC_562 29733411 0030533 0006412 562 cgcggggnggagcagccuggnagcucgucgggcucauaacccgaagaucgucggnucaaauccggcccccgcaacca ...<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>....... .(.(((([.((.(.]....[..).))..((((.......))))......(((((..]....))))))))).)..... 70S ribosome-EF-Tu H84A complex with GTP and near-cognate tRNA (Complex C2); tRNA-fMet 5wf0 x 12 3.6 29733411 562 acuaugcucacg ............ ............ 70S ribosome-EF-Tu H84A complex with GTP and near-cognate tRNA (Complex C2); mRNA 5wf0 y 76 3.6 RF00005 URS00005AA258_562 29733411 0030533 0006412 562 gcccgganagcucagncggnagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..))))(((((.........)))).)...(((((..]....)))))))))))).... 70S ribosome-EF-Tu H84A complex with GTP and near-cognate tRNA (Complex C2); Phe-tRNA-Phe 5wfk A 2900 3.4 RF02540,RF02541 URS00021ED92F_562 29733411 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggaggagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcaugcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaacucaucuccggggguagagcacuguuucggcaagggggucacgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugugaagguguacugugagguaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggcgacuugcucguggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccgggagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacuccuugagaguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu .<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<.<..>.>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>...[.....<......>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<....<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>....>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))....].]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<<..>>>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<......<<...<<<.<<<<...<<<<<<<..>>>>>.>>...>>>>.>>>..>>.......>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<...<........<<<<<.......<<.........>>..............<<<......>>>..>>>>>....>...>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<......>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>>...<<<<<....>>>>>....>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<<.<<....>>..>>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>.. ..((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((.(....).))))).(((((((.(.........).))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((..............(......(((.(((...(((((......)))))[[......(((.....]])))...)))...)))......).............)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((((..)))))))..)))).[.(.(........).).((((((....(((((((((((((..((....((.....))....))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((.(......).))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(..(..(..)..)...)...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.(((.((.....(.....((..(((((...(........((.((.(.......................).....(..(((......)))).)).))....)...))))).))...........]]].)...)).)))))))...)))))))((((.(..........).))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((.(...((((....((((..(((..((((((((((((...{{{.).))))))((..(((....(((((.((((((.((.....)))))))).)..))))....)))...))(..(((........)))...))))))...)))...))))(..).....))))...).....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....((....(((((..).))))....))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((.(..(((..(....(..........(..(............(((.((......)).)))...................)..).)....)..)))..).)))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((.....((((....))))....))...))))).))).....))..).)))))))... 70S ribosome-EF-Tu H84A complex with GTP and near-cognate tRNA (Complex C3); 23S rRNA 5wfk B 120 3.4 RF00001 URS00008116C5_562 29733411 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. (.((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))).). 70S ribosome-EF-Tu H84A complex with GTP and near-cognate tRNA (Complex C3); 5S rRNA 5wfk a 1540 3.4 RF00177,RF01959,RF01960 URS0000D56C37_562 29733411 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggaucaccuccu ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.....<<.<<<<.<<....>>.>>>>..>>....>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<......>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<......<<.)))>>........>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<.......<<<....>>>.....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<...<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>......>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ ........((((..[.[[[..)))).((.(.(((((...((((((((....(((.((...(.(..((.(......(((............))).....)..))).)......(((......(((((((..((...(((((((...((.....((((((....))))))......)).......(((....)))....((((((..(......))))))).)))))))..)).)))))))((((...((...((((((((.......)))))))).)).....))))..((((((((....))))...))))))).(((((............))))).((.(....).))....))))).).......(((...(..((....).)..))))..)).)))))...((((......((((....)))).....)))).....(((((...(....((((((((.......)))))))).....)....)))))...........((((......[......[[.)))]].........]...).....)))))).))..........((([[...(.((((...(((.(((((((.((.((((((.......((((((.....)))))).....))))))...)))))))))..(((((((((....(((((((....(((((((...((........))......)))))))....).......((....)).))))))...))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((.......(((....))).....)))...]]].](((((..((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((..(((((((....))))))).............))))).))).((.((....((((((.(....(((((((((....)))...(.(......).)...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...))..))))....))))))))..)).)))))))).(........((.....(((..((...(((....)))...))....))).....))...........(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))).))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... 70S ribosome-EF-Tu H84A complex with GTP and near-cognate tRNA (Complex C3); 16S rRNA 5wfk v 77 3.4 RF00005 URS00001BBAFC_562 29733411 0030533 0006412 562 cgcggggnggagcagccuggnagcucgucgggcucauaacccgaagaucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(((((.......)))))))))))..... 70S ribosome-EF-Tu H84A complex with GTP and near-cognate tRNA (Complex C3); tRNA-fMet 5wfk w 77 3.4 RF00005 URS00001BBAFC_562 29733411 0030533 0006412 562 cgcggggnggagcagccuggnagcucgucgggcucauaacccgaagaucgucggnucaaauccggcccccgcaacca ...<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>....... ...(((([.((.(.]....[..).))..((((.......))))......(((((..]....)))))))))....... 70S ribosome-EF-Tu H84A complex with GTP and near-cognate tRNA (Complex C3); tRNA-fMet 5wfk x 12 3.4 29733411 83333 acuaugcucacg ............ ............ 70S ribosome-EF-Tu H84A complex with GTP and near-cognate tRNA (Complex C3); mRNA 5wfk y 76 3.4 RF00005 URS00005AA258_562 29733411 0030533 0006412 562 gcccgganagcucagncggnagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<...<.......>..>......<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..))))((...............).)...(((((..]....)))))))))))).... 70S ribosome-EF-Tu H84A complex with GTP and near-cognate tRNA (Complex C3); Phe-tRNA-Phe 5wfs A 2900 3.0 RF02540,RF02541 URS00021ED92F_562 29733411 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggaggagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcaugcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaacucaucuccggggguagagcacuguuucggcaagggggucacgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugugaagguguacugugagguaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggcgacuugcucguggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccgggagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacuccuugagaguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<.........<.<.<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>.>.>......>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<........>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<<..>>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<..<<.......<<.........>>..............<<<......>>>..>>..>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<......>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<.<<<<<<<.<<.....>>>>>>>>>...>>>>...>>>>...>><..<<<<......>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<<.<<....>>..>>>>>>.>......>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<.<.<<.<<<............<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>...>>>.>>>..>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<.........>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. .(((((((......((((((((((.....(((..(((((((((((((......((((((....[[[.))).....((((((...(((]]]....))).......))))))...)))....(((....)))((((((......)))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((..............(....(((((.(((...(((((......)))))[[......(((.....]])))...)))...)))))....).............)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((....(.(((......))).)....)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((......(..(..)..).......)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((...........((..(((((....(...........(.(.......................).....(..(((......)))).).......)....))))).))...........]]].....))))))))))...)))))))((((((..........))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((...(((...(((....)))...)))...)))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..(.((...((((.(((((((.((.....)))))))))...))))..[)).)...))(..((..........))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((.............)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((.......(....(..........(..(............(((.((......)).)))...................)..).)....).......)))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.(((.(.....).)))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).)))))))).. 70S ribosome-EF-Tu H84A complex with GTP and near-cognate tRNA (Complex C4); 23S rRNA 5wfs B 120 3.0 RF00001 URS00008116C5_562 29733411 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((.(.....((.(((((....(((((((...(.....)...))))..)))...)))))..)).((.......((((((((...)))))))).......))...).)))))))). 70S ribosome-EF-Tu H84A complex with GTP and near-cognate tRNA (Complex C4); 5S rRNA 5wfs a 1540 3.0 RF00177,RF01959,RF01960 URS0000D56C37_562 29733411 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggaucaccuccu ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<.......<<.....<<.<<<<.<<....>>.>>>>..>>....>>.........<<.......<<<<<<<..<<...<<<<<.<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<......>>>>>>>.>.>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<.......<<<<..>>>>......>>>>.....<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>.......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>.>..........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(.(..((.(......(((............))).....)..))).)......(((......(((((((..(....(((((.....((.....((((.(....).))))......)).......(((....))).....(((((..(......))))))....)))))...).)))))))(((....(((..(((((((.........))))))))))......)))..((((.(((....)))....))))))).(((((............))))).((((....))))...)))))).).....(.(((...(.((......).).))))).)).))))))..((((......(.((....)).).....))))..((.(((((...(...(((.(((((.......))))).)).)...)....)))))....))..(((([[[...(((((.....((.]]])).......)))))))))...)))))))))..........((([[...(.((((...(((.(((.((..(((((((((.......((((((.....)))))).....)))))))..)).)).)))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((..((.......))..)))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.(...(((((..((((((((((......((........))........(.(((((((..(...(((((((..(((((((....))))))).............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....))))))))..)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........))))))).......)...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... 70S ribosome-EF-Tu H84A complex with GTP and near-cognate tRNA (Complex C4); 16S rRNA 5wfs v 77 3.0 RF00005 URS00001BBAFC_562 29733411 0030533 0006412 562 cgcggggnggagcagccuggnagcucgucgggcucauaacccgaagaucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... 70S ribosome-EF-Tu H84A complex with GTP and near-cognate tRNA (Complex C4); tRNA-fMet 5wfs w 77 3.0 RF00005 URS00001BBAFC_562 29733411 0030533 0006412 562 cgcggggnggagcagccuggnagcucgucgggcucauaacccgaagaucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .(.(((([.(..(.]....[..)..)..((((.......))))......(((((..]....))))))))).)..... 70S ribosome-EF-Tu H84A complex with GTP and near-cognate tRNA (Complex C4); tRNA-fMet 5wfs x 12 3.0 29733411 562 acuaugcucacg ............ ............ 70S ribosome-EF-Tu H84A complex with GTP and near-cognate tRNA (Complex C4); mRNA 5wfs y 76 3.0 RF00005 URS00005AA258_562 29733411 0030533 0006412 562 gcccgganagcucagncggnagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>><<<<<<<.....>>>>>>.>...<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..))))(((((.........)))).)...(((((..]....)))))))))))).... 70S ribosome-EF-Tu H84A complex with GTP and near-cognate tRNA (Complex C4); Phe-tRNA-Phe 5wis 1A 2871 2.703 RF02540,RF02541,RF00002 URS00001698E8_300852 28934499 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<....<<<<........>>>..>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..<<......(..>>...>>>.........<<......>>.).>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<<..>>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<...>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((...((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((.(..((..(......)....)))..)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((..((.........))...))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((.((((((.(......[..(((((..(((......((((((((....))))))))...)))..........].)))))).)))))).)))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..(((...)))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with methymycin and bound to mRNA and A-, P- and E-site tRNAs at 2.7A resolution; 23S ribosomal RNA 5wis 1B 120 2.703 RF00001 URS000080DEE8_300852 28934499 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the Thermus thermophilus 70S ribosome in complex with methymycin and bound to mRNA and A-, P- and E-site tRNAs at 2.7A resolution; 5S Ribosomal RNA 5wis 1a 1500 2.703 RF00177,RF01959,RF01960 URS000080DFED_300852 28934499 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<......>>....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((((((....))))))).)))))......(((......((((((((..((...(((((((.(((((....(((((......))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((...(((.(((....))).)))....(((....)))....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the Thermus thermophilus 70S ribosome in complex with methymycin and bound to mRNA and A-, P- and E-site tRNAs at 2.7A resolution; 16S Ribosomal RNA 5wis 1v 13 2.703 28934499 10665 aaaaauguucuaa ............. ............. Crystal structure of the Thermus thermophilus 70S ribosome in complex with methymycin and bound to mRNA and A-, P- and E-site tRNAs at 2.7A resolution; mRNA 5wis 1w 74 2.703 RF00005 URS00005AA258_562 28934499 0030533 0006412 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[..)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with methymycin and bound to mRNA and A-, P- and E-site tRNAs at 2.7A resolution; A-site and E-site tRNAs 5wis 1x 76 2.703 RF00005 URS000041AF00_562 28934499 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with methymycin and bound to mRNA and A-, P- and E-site tRNAs at 2.7A resolution; P-site tRNA 5wis 1y 74 2.703 RF00005 URS00005AA258_562 28934499 0030533 0006412 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((......)))).((((.........)))).....(((((.......)))))))))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with methymycin and bound to mRNA and A-, P- and E-site tRNAs at 2.7A resolution; A-site and E-site tRNAs 5wis 2A 2800 2.703 RF02540,RF02541,RF00002 URS00001698E8_300852 28934499 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<........>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<..>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<...<<......<<<<<<<<....>>>>>>>>...>>.............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...((((((((.....))))))))....{.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).))))....(((((((((.[.....)))))))))....}.(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....(())....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((..(((.....((..........))......)))..)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((.().)))))))).))..........]]].)....))))))))))...)))))))(((((((..)))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((.(((((((((.(.........(((((...((......(((((.((....)).)))))...)).............)))))).))))))))).))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..((((((((........)))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(((...)).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with methymycin and bound to mRNA and A-, P- and E-site tRNAs at 2.7A resolution; 23S ribosomal RNA 5wis 2B 120 2.703 RF00001 URS000080DEE8_300852 28934499 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>>. ..(((((((((....((((((.(....(((((((...(.....)...))))..)))...).)))).))(((.......((((((((....)))))))).......))).))))))))).. Crystal structure of the Thermus thermophilus 70S ribosome in complex with methymycin and bound to mRNA and A-, P- and E-site tRNAs at 2.7A resolution; 5S Ribosomal RNA 5wis 2a 1503 2.703 RF00177,RF01959,RF01960 URS000080DFED_300852 28934499 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggau .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<.<<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<......>>....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<..<.<<<<<<<........>>>>>>>>...>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.... .....(((...[.[[[...))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((.(....).)))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((((((....)))))))....(........)....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.(.((....)).)).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}... Crystal structure of the Thermus thermophilus 70S ribosome in complex with methymycin and bound to mRNA and A-, P- and E-site tRNAs at 2.7A resolution; 16S Ribosomal RNA 5wis 2v 13 2.703 28934499 10665 aaaaauguucuaa ............. ............. Crystal structure of the Thermus thermophilus 70S ribosome in complex with methymycin and bound to mRNA and A-, P- and E-site tRNAs at 2.7A resolution; mRNA 5wis 2w 72 2.703 RF00005 URS00005AA258_562 28934499 0030533 0006412 562 cccgganagcucagggagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<..<<<<.....>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((...[.)))).((((.........))))......((((..]....)))).))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with methymycin and bound to mRNA and A-, P- and E-site tRNAs at 2.7A resolution; A-site and E-site tRNAs 5wis 2x 76 2.703 RF00005 URS000041AF00_562 28934499 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with methymycin and bound to mRNA and A-, P- and E-site tRNAs at 2.7A resolution; P-site tRNA 5wis 2y 73 2.703 RF00005 URS00005AA258_562 28934499 0030533 0006412 562 gcccgganagcucagggagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<.....>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[.)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with methymycin and bound to mRNA and A-, P- and E-site tRNAs at 2.7A resolution; A-site and E-site tRNAs 5wit 1A 2871 2.6 RF02540,RF02541,RF00002 URS00001698E8_300852 28934499 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<.....<<<........>>>......>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<.<<<<.......>>>>..>>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<.......<<<<<<<....>>>>>>>....>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<...>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.((((((.((..(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)))).)))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...((((((((....(((((......))))..)...))))))))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((..((.........))...))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((.((((((((.(......[..(((((..(((.......(((((((....)))))))....)))..........].)))))).)))))))).)))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..((((.))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with pikromycin and bound to mRNA and A-, P- and E-site tRNAs at 2.6A resolution; 23S Ribosomal RNA 5wit 1B 120 2.6 RF00001 URS000080DEE8_300852 28934499 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the Thermus thermophilus 70S ribosome in complex with pikromycin and bound to mRNA and A-, P- and E-site tRNAs at 2.6A resolution; 5S Ribosomal RNA 5wit 1a 1500 2.6 RF00177,RF01959,RF01960 URS000080DFED_300852 28934499 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<..[.>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>.......]..<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>.....<......>.....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((..)))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((((((....)))))))....(((....)))....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the Thermus thermophilus 70S ribosome in complex with pikromycin and bound to mRNA and A-, P- and E-site tRNAs at 2.6A resolution; 16S Ribosomal RNA 5wit 1v 13 2.6 28934499 10665 aaaaauguucuaa ............. ............. Crystal structure of the Thermus thermophilus 70S ribosome in complex with pikromycin and bound to mRNA and A-, P- and E-site tRNAs at 2.6A resolution; mRNA 5wit 1w 74 2.6 RF00005 URS00005AA258_562 28934499 0030533 0006412 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcaccn <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[..)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with pikromycin and bound to mRNA and A-, P- and E-site tRNAs at 2.6A resolution; A-site tRNA 5wit 1x 76 2.6 RF00005 URS000041AF00_562 28934499 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with pikromycin and bound to mRNA and A-, P- and E-site tRNAs at 2.6A resolution; P-site tRNA 5wit 1y 74 2.6 RF00005 URS00005AA258_562 28934499 0030533 0006412 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((......)))).((((.........)))).....(((((.......)))))))))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with pikromycin and bound to mRNA and A-, P- and E-site tRNAs at 2.6A resolution; E-site tRNA 5wit 2A 2800 2.6 RF02540,RF02541,RF00002 URS00001698E8_300852 28934499 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>....<<<<<.....<<....>>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<........>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<..>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((()))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((....(...............)....)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((((((()))))))))).))..........]]].)....))))))))))...)))))))(((((((())))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((....))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(......[..(((((...((......(((((.((....)).)))))...))...........].)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....))))))).((...)).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with pikromycin and bound to mRNA and A-, P- and E-site tRNAs at 2.6A resolution; 23S Ribosomal RNA 5wit 2B 120 2.6 RF00001 URS000080DEE8_300852 28934499 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> .((((((((((....((((((.(....(((((((...(.....)...))))..)))...).)))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the Thermus thermophilus 70S ribosome in complex with pikromycin and bound to mRNA and A-, P- and E-site tRNAs at 2.6A resolution; 5S Ribosomal RNA 5wit 2a 1503 2.6 RF00177,RF01959,RF01960 URS000080DFED_300852 28934499 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggau .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>....<<.....>>....>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((((..((((((......)))))).(....(....)....)))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(.(((((......]...))))).)......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}... Crystal structure of the Thermus thermophilus 70S ribosome in complex with pikromycin and bound to mRNA and A-, P- and E-site tRNAs at 2.6A resolution; 16S Ribosomal RNA 5wit 2v 13 2.6 28934499 10665 aaaaauguucuaa ............. ............. Crystal structure of the Thermus thermophilus 70S ribosome in complex with pikromycin and bound to mRNA and A-, P- and E-site tRNAs at 2.6A resolution; mRNA 5wit 2w 72 2.6 RF00005 URS00005AA258_562 28934499 0030533 0006412 562 cccgganagcucagggagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcaccn <<<<<<..<<<<.....>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((...[.)))).((((.........)))).....(((((..]....)))))))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with pikromycin and bound to mRNA and A-, P- and E-site tRNAs at 2.6A resolution; A-site tRNA 5wit 2x 76 2.6 RF00005 URS000041AF00_562 28934499 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with pikromycin and bound to mRNA and A-, P- and E-site tRNAs at 2.6A resolution; P-site tRNA 5wit 2y 73 2.6 RF00005 URS00005AA258_562 28934499 0030533 0006412 562 gcccgganagcucagggagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<.....>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....)))).((((.........)))).....(((((.......)))))))))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with pikromycin and bound to mRNA and A-, P- and E-site tRNAs at 2.6A resolution; E-site tRNA 5wlc L0 488 3.8 URS000007769E_1247190 28945246 1247190 gaagacaagugcuugucguucguuaauggccucgucaaacgguggagagagucgcuaggugaucgucagaucugccuagucucuauacagcguguuuaauugacauggguugaugcguauugagagauacaauuugggaagaaauucccagaguguguuucuuuugcguuuaaccugaacagucucaucgugggcaucuugcgauuccauuggugagcagcgaaggauuugguggauuacuagcuaauagcaaucuauuucaaagaauucaaacuugggggaaugccuuguugaauauucuucaaguguaaccuccucucaaaucagcgauaucaaacguaccccgugaaacaccgggguaucuguuugguggaaccugauuagaggaaacucaaagagugcuaugguauggugacggagugcgcuggucaagaguguaaaagcuuuuugaacagagagcauuuccggcagcagagauuucagcuguu <<<<<<<<<..>>>>>>.>>>............<<<<<<<<.<<...<<<<..<<<<<<<<<<<....>>>>.>>>>>>>>>>>...>>.>>>......>>>>>..<<<<<<..<<<<<..<<<<<<<<<<.<<<<<<<<....>>>>>>>>.>>>>>>>>>>.>>>>>.>>>>>>.......<<<<<<<<<<<...........>>>>>.>>>>>>.........................<<<...>>>.........................<<<<<..<<<<<<<..<<<..>>>..>>>>.>>.>>>>>>.....<<<<<<...<<<<<<<<<<<<<<<<........>>>>>>>.>.>>>>>>>>....>>>>>>.................................<<<<<<<<.<<<.<<<<<<<<......>>>>.>>>>.>>>...>>>>.>>>><<<<<.<<<..>>>.>>>>>. (((((((((())))))).)))............((((((((.((...((((..(((((((((((....)))).)))))))))))...)).)))......)))))..(((((...(((((..((((((((((..(((((((....)))))))..)))))))))).)))))..))))).....(.((((((((((((.....)....))))).)))))))........................(((...))).........................(((((..(((((((..(((())))..)))).)).)))))).....((((((....((((((((((((((((.....).))))))).).))))))).....)))))).................................((((.(((.(((.((((((((......)))).)))).)))...)))..))))(((((.((....)).))))). The complete structure of the small subunit processome; 5' ETS 5wlc L1 1025 3.8 RF01960,RF01959,RF00177 URS0000BC4691_1247190 28945246 0003735 0005840 1247190 agauaguuaucugguugauccugccaguagucauaugcuugucucagccaugcagcucauuaaaucaguuaucguuuauuugauagucaugguauaacugugguaauucuagagcuaaaaucucgacccuuuggaagagauguauuuauuagaucaaugucuucggacucuuugaugaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaagggcaggcuuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuagcucguaguugaacuauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcucaacacggggaaacucaccagguccagacacaauauuugugggugguggugcaugugaugcccuuguucuggcgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaaaacuccgucggggaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccggaacuaauuccguaggugaaccugcggaa .............................<<.<<<<<<........<<<.<<<..<<<.......<<<..<<..<<....<<<..............<<.<<<.....>>>.>>.....<<<<<..<<....>>..>>>>>....<<<<....<<<<.<<<....>>>...>>>>...>>>>.........<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<.....<<<<<<<<.......>>>>>>>>.>>......>>>....<<<...<........>..>>>.>>>.<<.<<<..........>>>.>>.<.<<....>>.>.>>>>>>..<<<....<<<.....>>>..>>>...............<<<<<<<.<<<<<....>>>>>.>>>.>>>>......<<..<..<....>...>..>>.........<<<<<<.......<<<....>>>..................>>>>>>..>>>>>>>>..<.<<...<<<.<<...>>....<<<<<<.<<...<<<<..<<<.<<<<<<.<...<<<......>>>......>.>>>>>>.>>>......<<<....>>>..>>>>..>>.>>>.>>>...>>>...>>.>.....<<<<<<...<...<<<<.........>>>>...>>>>>>>.................<<.........>>.....<<<<<<<<<<<<..<<.<<<<<<..<<<.<<<<....................<<<<<......<<<<<...>>>>>......<<<<<<..>>.>>>>.....>>>>>>>>>.>>>.....<<<<<<<............<<<..<<<<....>>>>..>>>.....>>>>>>>............>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>............>>>>>..<<<<.<<>>.>>>>.<<<<<<<<<....>>>>>>>>> ............................(.(.((((((.....(..(((.(((..(((.......(((..((..((....(((..............((.(((.....))).)).....(((((..((....))..)))))..(.((((...(((((.(((....)))...)))))..)))).).....(.((((..(((.....))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......))).....((.(.(........).)))..))).((.(((..........))).)).(.((....)).).))))))(.(((...((((.....))).)))))......).......(((((((((((((....))))))))).))))......((.................)).........((((((.......(((....)))..................))))))..))))))).).(.((...((..((...))...(((.(((.((...((((..(((.(((((......((........)).........))))).))).......((....))...))))..).))))..))..).))...)).).....(((((....(...((((.........))))...).))))).................((.........)).....((((((((((((..((..(((((..(((..(((....................(((((.(....(((((...)))))...((.((((((())).)))))).).))))))))..))).(...((((((.............(((..((((....))))..)))......)))))).(....)..)..))))).....(.((((((.......)))))).)......))...))))))).(......)...)))))..((((.(()).))))..((((((((....)))))))). The complete structure of the small subunit processome; 18S pre-rRNA 5wlc L2 169 3.8 RF01846 URS0000B21E09_1247190 28945246 0006396 0005730 1247190 gucgacguacuucauaggaucauuucuauaggaaucgucacucuuugacucuucaaaagagccacugaauccaacuugguugaugagucccauaaccuuuguacccagugagaaaccguauggcgcgaugaucuacccauggguggguacaaauggcagucugacaagu .........................................................................<<<<<.................<<<<<<<<<<.<<.......<<<..>>>.........>><<<<..>>>>.>>>>>>>>.>>........>>>>> .........................................................................(((((......(..........((((((((((..(...(...((....))..)......).(((....))).)))))))).))....)...))))) The complete structure of the small subunit processome; U3 snoRNA 5wnp A 1512 3.3 RF00177,RF01959,RF01960 URS000080DE21_300852 29459784 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauccuuucu ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<.......>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<.<..<<<<<<<....>>>>>>>...<<<<....>>>>...>>>>>>>.<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<...<<<.....>>>.>>...>>>>>>>.....<<<<<....>>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<<..>>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>........... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.....)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((..((..(((((((....)))))))....(((....)))....)).))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(....(((.....)))..)...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((.((((((...(.((((....(((....))).)))).)..)))))).))))))..))).))))..).))...)..)..(((((((((....)))))))))}.......... Crystal Structure of 30S ribosomal subunit from Thermus thermophilus; 16S Ribosomal RNA rRNA 5wnp b 15 3.3 URS0000CBFF57_300852 29459784 300852 uagacunuunaucua ..<<.......>>.. ............... Crystal Structure of 30S ribosomal subunit from Thermus thermophilus; RNA (5'-R(P*UP*AP*GP*AP*CP*UP*(70U)P*UP*UP*(12A)P*AP*(PSU)P*CP*UP*A)-3') 5wnt A 1512 3.3 RF00177,RF01959,RF01960 URS000080DE21_300852 29459784 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauccuuucu ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<.......>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<.<..<<<<<<<....>>>>>>>...<<<<....>>>>...>>>>>>>.<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<...<<<.....>>>.>>...>>>>>>>.....<<<<<....>>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<<..>>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>........... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.....)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((..((..(((((((....)))))))....(((....)))....)).))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(....(((.....)))..)...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((.((((((...(.((((....(((....))).)))).)..)))))).))))))..))).))))..).))...)..)..(((((((((....)))))))))}.......... Crystal Structure of 30S ribosomal subunit from Thermus thermophilus; 16S Ribosomal RNA rRNA 5wnt b 15 3.3 URS0000CBFF57_300852 29459784 300852 uagacunuunaucua .<<<.......>>>. ............... Crystal Structure of 30S ribosomal subunit from Thermus thermophilus; RNA (5'-R(P*UP*AP*GP*AP*CP*UP*(70U)P*UP*UP*(12A)P*AP*(PSU)P*CP*UP*A)-3') 5wnu A 1512 3.4 RF00177,RF01959,RF01960 URS000080DE21_300852 29459784 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauccuuucu ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<.......>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<.<..<<<<<<<....>>>>>>>...<<<<....>>>>...>>>>>>>.<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<...<<<.....>>>.>>...>>>>>>>.....<<<<<....>>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<<..>>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>........... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.....)))))))))).)))))......(((......(((.((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..)))))).)))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((..((..(((((((....)))))))...((((....)))..).)).))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(....(((.....)))..)...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((.((((((...(.((((....(((....))).)))).)..)))))).))))))..))).))))..).))...)..)..(((((((((....)))))))))}.......... Crystal Structure of 30S ribosomal subunit from Thermus thermophilus; 16S Ribosomal RNA rRNA 5wnv A 1512 3.3 RF00177,RF01959,RF01960 URS000080DE21_300852 29459784 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauccuuucu ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<.......>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<.<..<<<<<<<....>>>>>>>...<<<<....>>>>...>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<...<<<.....>>>.>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<<..>>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>........... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.....)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((..((..(((((((....)))))))....(((....)))....)).))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(....(((.....)))..)...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((.((((((...(.((((....(((....))).)))).)..)))))).))))))..))).))))..).))...)..)..(((((((((....)))))))))}.......... Crystal Structure of 30S ribosomal subunit from Thermus thermophilus; 16S Ribosomal RNA rRNA 5wnv b 15 3.3 URS0000CBFF57_300852 29459784 300852 uagacunuunaucua ..<<.......>>.. ............... Crystal Structure of 30S ribosomal subunit from Thermus thermophilus; RNA (5'-R(P*UP*AP*GP*AP*CP*UP*(70U)P*UP*UP*(12A)P*AP*(PSU)P*CP*UP*A)-3') 5wsg B 13 4.0 URS0000A763A3_559292 27980089 559292 auaaauuuuuaag ............. ............. Cryo-EM structure of the Catalytic Step II spliceosome (C* complex) at 4.0 angstrom resolution; 5'-exon 5wsg N 15 4.0 URS0000A7639B_559292 27980089 559292 guauguauuuauuuu ............... ............... Cryo-EM structure of the Catalytic Step II spliceosome (C* complex) at 4.0 angstrom resolution; 5'-intron-lariat 5wsg D 117 4.0 RF00020 URS000053F313_559292 27980089 0000244,0000353 0005682,0046540 559292 ggaggucaacaucaagaacugugggccuuugccuauagaacuuauaacgaacaugguucuugccuuuuaccagaaccauccggguguugucuccauccauauuuuuuggaacuuuuc <<<<<.<<<<<<<.....<<<<<<<<....>>>>>>>>..............<<<<<<<<...........>>>>>>>>...>>>>>>>>>>>>....................... (((((.(((((((.....((((((((....)))))))).........((...((((((((.(.......).)))))))).))))))))))))))....................... Cryo-EM structure of the Catalytic Step II spliceosome (C* complex) at 4.0 angstrom resolution; U5 snRNA 5wsg E 103 4.0 RF00026 URS00006184A9_559292 27980089 0030621 0000244,0000353 0005688,0046540 559292 guucgcgaaguaacccuucguggacauuuggucaauuugaaacaauacagagaugaucagcaguuccccugcauaaggaugaaccguuuuacaaagagauuua <<<<<<<<<<.....>>>>>>>>>>.....................................<<<..<<<.....>>>...>>>................... ((((.(((((.....))))).)))).....................................(((.((((.....)))..))))................... Cryo-EM structure of the Catalytic Step II spliceosome (C* complex) at 4.0 angstrom resolution; Saccharomyces cerevisiae S288c SNR6 snRNA 5wsg L 91 4.0 RF00004 URS000023C730_559292 27980089 0045131 0000348 0005686 559292 acgaaucucuuugccuuuuggcuuagaucaaguguaguaucuguucuuuucaacauuuuuuggcaccgcgacccucgcacuuguggagucg ..................................................................<<...<<...........>>...>> ..................................................................((...(.............)...)) Cryo-EM structure of the Catalytic Step II spliceosome (C* complex) at 4.0 angstrom resolution; RNA (91-MER) 5wsg M 23 4.0 URS0000B21DCC_559292 27980089 559292 uuuuaagaacuagauacuaacac ....................... ....................... Cryo-EM structure of the Catalytic Step II spliceosome (C* complex) at 4.0 angstrom resolution; 3'-intron-lariat 5wsg b 14 4.0 URS0000B21DD2_559292 27980089 559292 uuauaguuuuuuua .............. .............. Cryo-EM structure of the Catalytic Step II spliceosome (C* complex) at 4.0 angstrom resolution; 3'-exon-intron 5wyj 3A 157 8.7 RF01846 URS0000B21E09_559292 28244370 0006396 0005730 559292 gucgacguacuucauaggaucauuucacucuuugacucuucaaaagagccacugaauccaacuugguugaugaccuuuguaccccagagugagccguugcauuuuauggcgcgaugaucuugacccauggguggguacaaauggcagucugacaagu ............................................................<<<<<........<<<<<<<<<<<....<....<<<<.<....>.>>>>.........>...<<<<..>>>>>>>>>>>>>.>>........>>>>> .............................................................((((......(.(((((((((((....(....((((........)))).........)...((((..))))))))))))).))....)...)))). Cryo-EM structure of the 90S small subunit pre-ribosome (Dhr1-depleted, Enp1-TAP, state 1); U3 RNA 5wyj 5A 462 8.7 URS000007769E_559292 28244370 559292 aagcaguugaagacaaguucgaggcuugucguucguuauguuuugucaaacgguggagagagucgcuaggugaucgucagaucugccuagucucuauacagcguguuuaauugacuggguugaugcguauugagagauacaauuugggaagaaauucccagaguguguuucuuuugcguuuaaccugaacagucucaucgugggcauauuccauuggugagcagcgaaggauuugguggauugggggaaugccuuguugaauagccggucgcaagacugugauucuucaaguguaaccuccucucaaaucagcgauaucaaacguaccaccgggguaucuguuugguggaaccugauuagaggaaacucaaagagugccggagugcgcuggucaagaguguaaaagcuuuuugaacagagagcauuuggcagcagagagaccugaucuggaauuucagcugu ..<<<...<<<<<<<<<<.....>>>>>>>.>>>....>>>....<<<<<<<.<<...<<<<..<<<<<<<..<......>...>>>>>>>>>>>...>>.>>>......>>>>..<<<<<....<<<<..<<<<<<<<<<.<<<<<<<<....>>>>>>>>.>>>>>>>>>>.>>>>...>>>>>.......<<<<<<<<<<<.....>>>>.>>>>>>>.....................<<<<...<<<<<<<..<<<<....<<<......>>>...>>>>..>>>>.>>>.>>>>...<<.<<<<<<...<<<<<<<<<<<<<.....>>>>>..>>>>>>>>....>>>>>>.>>...................<<<<<<.<<<.<<<<<<<.........>>>>>>>.>>>...>>>>>>.<<<<<.<<<<..<<.<..>.>>..>>>>.>>>>> .((((...(((((((((.......)))))).)))....))))...(((((((.((...((((..((((((..(.(....).)...))))))))))...)).)))......))))...((((....((.(...(((((((((.((((((((....)))))))).)))))))))..).))...))))........((((((((((.......))).))))))).....................((((...(((((((..((((...(.(((....))).)..))))..)))).))).))))...((.((((((...(((((((((((((.....)))))..))))))))....)))))).))...................((((((.(((.((((.(..(......).).)))).)))...))))))..((((.((((..((.(..).))..)))).)))). Cryo-EM structure of the 90S small subunit pre-ribosome (Dhr1-depleted, Enp1-TAP, state 1); 5ETS RNA 5wyj SA 1115 8.7 RF01960,RF01959,RF00177 URS0000B21DE0_559292 28244370 0003735 0005840 559292 guugauccugcagucauaugcuugucucaaagccaugcaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaagggcaggcgcuuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagucuggucagcagccgcgcagcuccaauagcguauauuaagcucguaguugaacuuuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaauagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucggaguauggucgcaaugacggaagggcaccaccaggaguggagccugcggcacucaacacgaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguacaggucugugaugcccuuagacguucugggccacgcgcgcuacacugacggagccagcgagccuuggccgagaggucuugguaaaaacuccgucgugcaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcgcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagucauuaaagaaauuuaau ...............<<<<<<..........<<<.<<<.....<<........<<<..<<..<<....<<<..................<<....<<.<<<.....>>>.>>.....>>.........<<<<<..<......>..>>>>>..<.<<<<<<......>>>>>>.>.......<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<......>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>.>>>>>>...<<<<....<<<.....>>>..>>>>..............<<.<<<...<<<<....>>>>...>>>..>>......<<..<...........>..>>.........<<<<<<.<<<.............>>>>>>>>>..>>>>>>.....<.<<...<<<.<<..>>....<<<<<<.<<...<<<<..<<<.<<<<<<.<...<<<......>>>......>.>>>>>>.>>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>............................<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<...................<<<<<.<....<<<<<.<......<<.<<<........>>>.>>.....>>>>>>...<<.<<<.....<<<<..>.>>>.......>>>>>.....>.>>>>>....>>>>.>>>.....<<<<<<<........<<..<<<<....>>>>..>>......>>>>>>>............>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>..........<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<......................>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>.........<<<<<<....>>>>>> .............(.((((((...(.(....(((.((......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......)))))).)...).(.((((...(.(..)..)..)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).))...((....))....)))))....(((...((((.....))).)))).......).).....((.(..(...(((....)))...)..)..))......(.(.(...........))..).........(((((..((.....((....))..)).)))))..)))))))......((....((.((..))...((..(((.((...((((..((..((((((.(...((........))......).))))))..)).......((....))...))))..)).)))...)..)))....))......(((..((((((((.(((........)))))))))))..)))...((....)).................(((.(((((((..((..(((((..(((..(((...................((((..(....(((((.....(..((.(((........))).))....).)))))....(.(((...(.((((()).))).....).))))......)..))))....)))..))).(...(((((((.........(..((((....))))..).......))))))).........)..))))).....(.((((((.......)))))).)......))...))))))))))..........((.(..((((.((..(.(((((.((.(((..(.((..(...(........)...)..)).)..))).)).))))))..)).))))...).))..........(((((....))))). Cryo-EM structure of the 90S small subunit pre-ribosome (Dhr1-depleted, Enp1-TAP, state 1); 18S ribosomal RNA 5wyk 3A 157 4.5 RF01846 URS0000B21E09_559292 28244370 0006396 0005730 559292 gucgacguacuucauaggaucauuucacucuuugacucuucaaaagagccacugaauccaacuugguugaugaccuuuguaccccagagugagccguugcauuuuauggcgcgaugaucuugacccauggguggguacaaauggcagucugacaagu ............................................................<<<<<........<<<<<<<<<<<....<....<<<<.<....>.>>>>.........>...<<<<..>>>>>>>>>>>>>.>>........>>>>> .............................................................((((......(..((((((((((....(....(((..........))).........)...((((..))))))))))))).).....)...)))). Cryo-EM structure of the 90S small subunit pre-ribosome (Mtr4-depleted, Enp1-TAP); U3 RNA 5wyk 5A 462 4.5 URS000007769E_559292 28244370 559292 aagcaguugaagacaaguucgaggcuugucguucguuauguuuugucaaacgguggagagagucgcuaggugaucgucagaucugccuagucucuauacagcguguuuaauugacuggguugaugcguauugagagauacaauuugggaagaaauucccagaguguguuucuuuugcguuuaaccugaacagucucaucgugggcauauuccauuggugagcagcgaaggauuugguggauugggggaaugccuuguugaauagccggucgcaagacugugauucuucaaguguaaccuccucucaaaucagcgauaucaaacguaccaccgggguaucuguuugguggaaccugauuagaggaaacucaaagagugccggagugcgcuggucaagaguguaaaagcuuuuugaacagagagcauuuggcagcagagagaccugaucuggaauuucagcugu ..<<<...<<<<<<<<<<.....>>>>>>>.>>>....>>>....<<<<<<<.<<...<<<<..<<<<<<<.<<......>>..>>>>>>>>>>>...>>.>>>......>>>>..<<<<<....<<<<..<<<<<<<<<<.<<<<<<<<....>>>>>>>>.>>>>>>>>>>.>>>>...>>>>>.......<<<<<<<<<<<.....>>>>.>>>>>>>.....................<<<<...<<<<<<<..<<<<....<<<......>>>...>>>>..>>>>.>>>.>>>>...<<.<<<<<<...<<<<<<<<<<<<<.....>>>>>..>>>>>>>>....>>>>>>.>>...................<<<<<<.<<<.<<<<<<<.........>>>>>>>.>>>...>>>>>>.<<<<<.<<<<..<<......>>..>>>>.>>>>> .((((...((((((((((.....))))))).)))....))))....((((((.((...((((..((((((....(....).....))))))))))...)).)))......)))...((((.....((((...(((((((((.((((((((....)))))))).)))))))))..))))....)))).......(((((((((((.....)))).))))))).....................((((.....(((((..((((...(.(.(....).).)..))))..)))).)...))))...((.((((((...((.(((((.((((.....))))...))))).))....)))))).))...................((((((.(((.((((.(..((....)).).)))).)))...))))))..((((.((((..((.(..).))..)))).)))). Cryo-EM structure of the 90S small subunit pre-ribosome (Mtr4-depleted, Enp1-TAP); 5ETS RNA 5wyk SA 1000 4.5 RF01960,RF01959,RF00177 URS0000B21DE0_559292 28244370 0003735 0005840 559292 guugauccugcagucauaugcuugucucaaagccaugcaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaagggcaggcgcuuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagucuggucagcagccgcgcagcuccaauagcguauauuaagcucguaguugaacuuuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaauagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucggaguauggucgcaaugacggaagggcaccaccaggaguggagccugcggcacucaacacacgcgcgcuacacugacggagccagcgagccuuggccgagaggucuugguaaaaacuccgucgugcaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcgcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagucauuaaagaaauuuaau ............<<.<<<<<<...<......<<<.<<<.....<<........<<<..<<..<<....<<<..................<<....<<.<<<.....>>>.>>.....>>.........<<<<<..<<....>>..>>>>>....<<<<<<......>>>>>>.........<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>.>>>>>>...<<<<....<<<.....>>>..>>>>........>.....<<.<<<<..<<<<....>>>>..>>>>..>>......<<..<...........>..>>.........<<<<<<.<<...............>>>>>>>>..>>>>>>>>...<.<<...<<<.<<..>>....<<<<<<.<<...<<<<..<<<.<<<<<<.<...<<<......>>>......>.>>>>>>.>>>.......<<....>>...>>>>..>.>>>>.>>>...>>>...>>.>....<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>....<....>..................<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<............>>>>.>>>.....<<<<<<<........<<..<<<<....>>>>..>>......>>>>>>>............>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>..........<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<......................>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>.........<<<<<<....>>>>>> ............((.((((((...(.(....(((.((......((........(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....))).)).((.(((..........))).))...((....))....)))))....(((...((((.....))).)))).......).).....((.(..(..((((....))))..)..)..))......(((.(...........)).)).........((((((.((.....((....))..))))))))..)))))))).....((...(((.((..))...(((.(((.((...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)).)))..))..))))...))......(((..((((((((.(((........)))))))))))..)))...((....)).................(((.(((((((..((..(((((..(((..(((............)))..))).(...(((((((........((..((((....))))..))......))))))).........)..))))).....((((((((.......))))))))......))...))))))))))..........((.(..((((.((..(.(((((.((.(((..(.((..(...(........)...)..)).)..))).)).))))))..)).))))...).))............(((....)))... Cryo-EM structure of the 90S small subunit pre-ribosome (Mtr4-depleted, Enp1-TAP); 18S ribosomal RNA 5x8p B 117 3.4 RF00001 URS0000538405_3562 28582576 0003735 0005840 3562 uucugguguccuaggcguagaggaaccacaccaauccaucccgaacuuggugguuaaacucuacugcggugacgauacuguaggggagguccugcggaaaaauagcucgacgccagg .<<<<<<<<<....<<<<<<<<.....<<<<<<<............>>>>>.>>....>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>> ..(..(((((....((((((((.....((..(((..(.....)...)))...))....)))))).))(((.......((((((((....)))))))).......))).)))))..). Structure of the 70S chloroplast ribosome from spinach; 5S rRNA 5x8p W 102 3.4 RF02541 URS000000A081_3562 28582576 0003735 0005840 3562 aaggucacggcgagacgagccguuuaucauuacgauaggugucaaguggaagugcagugauguaugcagcugaggcauccuaacagacccacagacuugaac ..<<<<<<<<<.......>>>>>............<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>............. ..(((...(((.......)))..............((((((((.(((....(((((....)))))...)))..))))).)))....)))............. Structure of the 70S chloroplast ribosome from spinach; 4.8S rRNA 5x8p A 2809 3.4 RF02540,RF02541 URS000028B73E_3562 28582576 0003735 0005840 3562 ucaaacgaggaaaggcuuacgguggauaccuaggcacccagagacgaggaagggcguauuaaucgacgaaaugcuucggggaguugaaaauaagcagagauccggagauucccgaauaggucaaccuuucgaacuucugcugaauccaugggcaggcaagagacaaccuggcgaacugaaacaucuuaguagccagaggaaaagaaagcaaaagcgauucccguaguagcggcgagcgaaaugggagcagccuaaaccgugaaaacgggguugugggagagcaauacaagcgucgugcugcuaggcgaaucaguggagugcggaacccuagauggugaaaguccaguagccgaaagcaucacuagcuuaugcucugacccgaguagcauggggcacguggaaucccgugugaaucagcaaggaccaccuugcaaggcuaaauacuccugggugaccgauagcgaaguaguaccgugagggaagggugaaaagaacccccaucggggagugaaauagaacaugaaaccguaagcucucaagcagugggagggggaccagacccugaccgcgugccuguugaagaaugagccggcgacucauaggcaguggcuugguuaagggaacccaccggagccguagcgaaagcgagucuucauagggcaauugucacugcuuauggacccgaaccugggugaucuauccaugaccaggaugaagcuugggugaaacuaaguggagguccgaaccgacugauguugaagaaucagcggaugaguugugguuaggggugaaaugccacucgaacccagagcuagcugguucuccccgaaaugcguugaggcgcagcaguugacuggacaucuagggguaaagcacuguuucggugcgggccgcgagagcgguaccaaaucgaggcaaacucugaauacuagauaugaccuccaaauaacaggggucaaggucggccagugagacgaugggggauaagcuucaucgucgagagggaaacagcccggaucaccagcuaaggccccuaaaugaccgcucagugauaaaggagguaggggugcagagacagccaggagguuugccuagaagcagccacccuugaaagagugcguaauagcucacugaucgagcgcucuugcgccgaagaugaacggggcuaagcggucugccgaagcugugggauguaaaaaaacaucgguaggggagcguuccguguuagggagaaacgcgugcgugagccgcguuggacgaagcggaagcgagaaugucggcuugaguaacgcaaacauuggugagaauccaaugccccgaaaaccuaaggguuccuccgcaagguucguccacggagggugagucagggccuaagaucaggccgaaaggcguagucgauggacaacaggugaauauuccuguacuaccccuuguuggucccgagggacggaggaggcuagguuagccgaaagaugguuaucgguucaaggacgcaaggugacccuguuuuucaggguaagaagggguagagaaaaugccucgagccaauguucgaguaccaggcgcuacggcgcugaaguaaccgaugccauacucccaggaaaagcucgaacgaccuucaacaaaaggguaccuguacccgaaaccgacacagguagguagguagagaauaccuaggggcgcgagacaacucucucuaaggaacucggcaaaauagccccguaacuucgggagaaggggugcccccucacaaagggggucgaagugaccaggcccgggcgacuguuuaccaaaaacacaggucuccgcaaagucguaagaccauguaugggggcugacgccugcccagugccggaaggucaaggaaguuggugaccugaugacaggggagccggcgaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgacccgcacgaaaggcguaacgaucugggcacugucucggagagaggcucggugaaauagacaugucugugaagaugcggacuaccugcaccuggacagaaagacccuaugaagcuuuacuguucccugggauuggcuuugggcuuuuccugcgcagcuuagguggaaggcgaagaaggcccccuuccgggggggcccgagccaucagugagauaccacucuggaagagcuagaauucuaaccuugugucaggaccuacgggccaagggacauucucagguagacaguuucuauggggcguaggccucccaaaagguaacggaggcgugcaaagguuuccucgggccggacggagauuggcccucgagugcaaaggcagaagggagcuugacugcaagacccacccgucgagcagggacgaaagucggccuuagugauccgacggugccgaguggaagggccgucgcucaacggauaaaaguuacucuagggauaacaggcugaucuuccccaagaguucacaucgacgggaagguuuggcaccucgaugucggcucuucgccaccuggggcuguaguauguuccaaggguugggcuguucgcccauuaaagcgguacgugagcuggguucagaacgucgugagacaguucgguccauauccggugugggcguuagagcauugagaggaccuuucccuaguacgagaggaccgggaaggacgcaccucugguguaccaguuaucgugcccacgguaaacgcuggguagccaagugcggagcggauaacugcugaaagcaucuaaguaguaagcccaccccaagaugagugcucuccua .............<<<<<<<<<<.....<<..<<<<<<<<<<<.<......<<<<<<.....((.>>>.....<<<<<<<..<<.))......>>.....>>>>>>>...>>>....<<<....>>>......<<<<<<<<.........>>>>>..>>>.>....<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<....<<<<....>>>>......<<<<<<<<<....<<<<...<<<.<<<<.<<<...<<.<<.....>>.>>((......<<<.....))>>>...>>>...>>>>.>>>..>>>>.>>>>>>..>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..>>>......>>.>>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>........<<<<..<<<<.......>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<...<<<...<<.......>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>..<<.<...<<<<<<.....<.<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>.>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<.<<<<<<<....<<<<<<.....<<<...<<<<<<<<...<<<<<........>>>.>>...>>>>>>>>..>>.>.....>>>>>>..<<<<<<.........>>>>>>..>>>>>>>..>>..<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<<.........<<<.<<....<<.........>>....>>.........<<......>>...>>>.....>>>>>>>>>>.>>..........))).....>>>>>>.>>>...>>>>>>><<<<<......>>>>>....>>>>>><.<<<<<<...........<<<<<.<<....>>>>>>.>.......>>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<.<<<<.<<<<.<<<<....<<<<..<<<..<<<<<<<<<<.....(((..>>>>>....<<<<<...<<<.<<<<<<.....>>>>>>.....<<<<<<.......>>>>>>..>>>..>>>>>.....<..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>>>....>>>>..>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<<<<<<.....>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<..<<<<<<..<<<<....>>>>...>>>>>>..>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<..<......<<<<.<<<<<<..<<<<<..<<<<<<<..<<.<<<.<<<<<<<<..............<<<..<<<......<<<<<<.......>.>>>>>...>>>............>>>.....>>>>>>>>.>>>.>>...<<<<<.<<<..........>>>>>>>>.....>>>>>>>...>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<..<<<<<<<.......>>>>>>>....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..>>>>..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<...<<<<..<<<<<<<<........>>>>>..>>>.<<<<<.....>>>>>.....>>>>.......>>>>>.....<<<<<<<....>>>.>>>>....>...>>>>>>>>>>>....<<<<<<<...<.<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>...>>>>>...>>>>.>>>>>..<.<<...<<<<<<...........>>>>>>...>>>.>>.>.......>>>>>>>.... .............(((((((((......((..(((((((((((.(......((((((..[..[[[)))...].((((((...(((]]..]..)))......))))))...)))....(((....)))......((.(((((.........)))))...)).)....((((((.....(...[..)......))))).).........((....))...((((......((.]...)).....))))...((([...(((......)))....(.(((.(((((.(..((((...(.(.((((.(((...((.((.....)).))[[(...).(((.....]])))...)))...)))).).)..))))))))))...)))]....(((((((...[.......)))))))....).(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((....))))............)......)))))))))......(.((((..((((.......))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.......))...)))...((....))..((((.....))))....)))))))))))))..((.(...((((((.....(.((((((((.((((...(((..(......)..)))...)[)))...(((.(((((.......<))))))))..).))))))).).(.(((....[)))...).]))))))......).))..((((((....(((((....)))))((.(((((((....((((((.....(((...(((((((.(..((...............))..).)))))))..)).).....))))))..((((((.........))))))..)))))))..))..((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((.((((((.....{...(((.(((...((.........))...))).....(...((......)).).))).....)))))).))).))..........]]].)...))))))))))...)))))))(((((......)))))....))))))(.((((((....(......(((((.((....)))))).)...)...))))))..).....))))))(......((.....((((((.......))))))((((....(((...((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((.(((((((((.((((....((((..(((..(((((.((((.....{{{..)))).(...((((....(((.((((((.....)))))).....((((((.......))))))..)))...))))....)(..(((((....)))))...))))))...)))...))))(..).....))))...))))...)))))..))))))))).))).....((......))..))).((((.....))))..))))..((((....(((((((..((..(....(.......(((((....(.{..).....)))))(((((((.....)))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((..((((((..((((....))))...))))))..))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..)))..))))))).)))))).....)).{..(((((.....].})))))..((((((((.(((..(......((((.((((((..(((((..(((((((..((.((..((((..((..(...........(((...((........(...(......)...).....)).............)))..)..).).))))..)).))...(((((.(((..........)))))))).....)))))))...)))))..(((.(...)[)))((((((..........]))))))(.((...(((((((.(((((((.........))))))..).((.[.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..)))))).......((((.(.((((((...((.......))...))))))...)))).)........((((.(.((((..((((((((........)))))..))).(((((.....))))).....))))...)...))))......(((((((....))).))))..>.)...)))))))))))[...(((((((...(.((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))...)))))...)))).)))))..(.((....((((.....}.......))))....))).)).)..]....))))))).... Structure of the 70S chloroplast ribosome from spinach; 23S rRNA 5x8p a 1480 3.4 RF00177,RF01959,RF01960 URS00003B54E2_3562 28582576 0003735 0005840 3562 ucauggagaguucgauccuggcucaggaugaacgcuggcggcaugcuuaacacaugcaagucggacgggaaguguuuccaguggcggacgggugaguaacgcguaagaaccugcccuugggaggggaacaacagcuggaaacggcugcuaauaccccguaggcugagaagcaaaaggaggaauccgcccgaggaggggcucgcgucugauuagcuaguuggugagguaauagcuuaccaaggcgaugaucaguagcugguccgagaggaugaucagccacacugggacugagacacggcccagacuccuacgggaggcagcaguggggaauuuuccgcaaugggcgaaagccugacggagcaaugccgcguggaggcagaaggcccacgggucgugaacuucuuuucccggagaagaagcaaugacgguauccggggaauaagcaucggcuaacucugugccagcagccgcgguaagacagaggaugcaagcguuauccggaaugauugggcguaaagcgucuguagguggcuuuuuaaguccgccgucaaaucccagggcucaacccuggacaggcgguggaaacuaccaagcuggaguacgguaggggcagagggaauuuccgguggagcggugaaaugcguagagaucggaaagaacaccaacggcgaaagcacucugcugggccgacacugacacugagagacgaaagcuaggggagcgaaugggauuagauaccccaguaguccuagccguaaacgauggauacuaggcgcugugcguaucgacccgugcaguguuguagcuaacgcguuaaguaucccgccuggggaguacguucgcaagaaugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaaagcgaagaaccuuaccagggcuugacaugccgcgaauccucuugaaagagaggggugccuucgggaacgcggacacagguggugcauggcugucgucagcucgugccguaagguguuggguuaagucccgcaacgagcgcaacccucguguuuaguugccaacguguuuggaacccugaacagacugccggugauaagccggaggaaggugaggaugacgucaagucaucaugccccuuaugcccugggcgacacacgugcuacaauggccgggacaaagggucgcgaucccgcgagggugagcuaaccccaaaaacccguccucaguucggauugcaggcugcaacucgccugcaugaagccggaaucgcuaguaaucgccggucagccauacggcggugaauucguucccgggccuuguacacaccgcccgucacacuaugggagcuggccaugcccgaagucguuaccuuaaccgcaaggagggggaugccgaaggcagggcuagugacuggagugaagucguaacaagguagccguacuggaaggugcggcuggaucaccucc .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<<<<..>>>>>.>>>>>......<<.......<<<<.<<..<<<..<<<<<<<.<<<<.....<<<<<......>>>>>......>>>>....<<<....>>>....<<<....>>>.>>>>>>>.>>>.>>.>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>...<<<<<<<..................>>>>>>>.....<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<..<.<<<<<<<<<<<.....<<<<<<.....>>>>>>...>>>>>>>>>..>>>..>>>>...<<<.<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>..>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<........>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<<<.....>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<.<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>.>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<.<<<<....<.<<<<.<<<<..<<....>>.>>>>>>>>.>...>>>>.>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>........... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((....)))).)))))......(((......((((.((..(((..(((((((.((((.....((((((....))))))......))))....(((....)))....(((....))).))))))).))).)).))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(.(((....)))..))))).)).))))))..((((......((((....)))).....))))..(..(((((...(.........)....))))).....).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.((((..(.(((((((((((.....((((((.....))))))...)))))))))..)))..))))..((((.((((...((((((((...((((((((...((........))......))))))))...).......((....)).)))))))..))))..)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((.((........)).))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((...((((((....))))))....((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((((.....))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...((.((((.....(((..((...(((....)))...))....))).....)))).))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((.((((....(.((((.((((..((....)).)))))))).)...)))).)))))))..))).))))..).))...)..)..(((((((((....)))))))))}.......... Structure of the 70S chloroplast ribosome from spinach; 16S rRNA 5x8t B 117 3.3 RF00001 URS0000538405_3562 28582576 0003735 0005840 3562 uucugguguccuaggcguagaggaaccacaccaauccaucccgaacuuggugguuaaacucuacugcggugacgauacuguaggggagguccugcggaaaaauagcucgacgccagg .<<<<<<<<<....<<<<<<<<.....<<<<<<<............>>>>>.>>....>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>> ..(..(((((....((((((((.....((..(((..(.....)...)))...))....)))))).))(((.......((((((((....)))))))).......))).)))))..). Structure of the 50S large subunit of chloroplast ribosome from spinach; 5S rRNA 5x8t W 102 3.3 RF02541 URS000000A081_3562 28582576 0003735 0005840 3562 aaggucacggcgagacgagccguuuaucauuacgauaggugucaaguggaagugcagugauguaugcagcugaggcauccuaacagacccacagacuugaac ..<<<<<<<<<.......>>>>>............<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>............. ..(((...(((.......)))..............((((((((.(((....(((((....)))))...)))..))))).)))....)))............. Structure of the 50S large subunit of chloroplast ribosome from spinach; 4.8S rRNA 5x8t A 2809 3.3 RF02540,RF02541 URS000028B73E_3562 28582576 0003735 0005840 3562 ucaaacgaggaaaggcuuacgguggauaccuaggcacccagagacgaggaagggcguauuaaucgacgaaaugcuucggggaguugaaaauaagcagagauccggagauucccgaauaggucaaccuuucgaacuucugcugaauccaugggcaggcaagagacaaccuggcgaacugaaacaucuuaguagccagaggaaaagaaagcaaaagcgauucccguaguagcggcgagcgaaaugggagcagccuaaaccgugaaaacgggguugugggagagcaauacaagcgucgugcugcuaggcgaaucaguggagugcggaacccuagauggugaaaguccaguagccgaaagcaucacuagcuuaugcucugacccgaguagcauggggcacguggaaucccgugugaaucagcaaggaccaccuugcaaggcuaaauacuccugggugaccgauagcgaaguaguaccgugagggaagggugaaaagaacccccaucggggagugaaauagaacaugaaaccguaagcucucaagcagugggagggggaccagacccugaccgcgugccuguugaagaaugagccggcgacucauaggcaguggcuugguuaagggaacccaccggagccguagcgaaagcgagucuucauagggcaauugucacugcuuauggacccgaaccugggugaucuauccaugaccaggaugaagcuugggugaaacuaaguggagguccgaaccgacugauguugaagaaucagcggaugaguugugguuaggggugaaaugccacucgaacccagagcuagcugguucuccccgaaaugcguugaggcgcagcaguugacuggacaucuagggguaaagcacuguuucggugcgggccgcgagagcgguaccaaaucgaggcaaacucugaauacuagauaugaccuccaaauaacaggggucaaggucggccagugagacgaugggggauaagcuucaucgucgagagggaaacagcccggaucaccagcuaaggccccuaaaugaccgcucagugauaaaggagguaggggugcagagacagccaggagguuugccuagaagcagccacccuugaaagagugcguaauagcucacugaucgagcgcucuugcgccgaagaugaacggggcuaagcggucugccgaagcugugggauguaaaaaaacaucgguaggggagcguuccguguuagggagaaacgcgugcgugagccgcguuggacgaagcggaagcgagaaugucggcuugaguaacgcaaacauuggugagaauccaaugccccgaaaaccuaaggguuccuccgcaagguucguccacggagggugagucagggccuaagaucaggccgaaaggcguagucgauggacaacaggugaauauuccuguacuaccccuuguuggucccgagggacggaggaggcuagguuagccgaaagaugguuaucgguucaaggacgcaaggugacccuguuuuucaggguaagaagggguagagaaaaugccucgagccaauguucgaguaccaggcgcuacggcgcugaaguaaccgaugccauacucccaggaaaagcucgaacgaccuucaacaaaaggguaccuguacccgaaaccgacacagguagguagguagagaauaccuaggggcgcgagacaacucucucuaaggaacucggcaaaauagccccguaacuucgggagaaggggugcccccucacaaagggggucgaagugaccaggcccgggcgacuguuuaccaaaaacacaggucuccgcaaagucguaagaccauguaugggggcugacgccugcccagugccggaaggucaaggaaguuggugaccugaugacaggggagccggcgaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgacccgcacgaaaggcguaacgaucugggcacugucucggagagaggcucggugaaauagacaugucugugaagaugcggacuaccugcaccuggacagaaagacccuaugaagcuuuacuguucccugggauuggcuuugggcuuuuccugcgcagcuuagguggaaggcgaagaaggcccccuuccgggggggcccgagccaucagugagauaccacucuggaagagcuagaauucuaaccuugugucaggaccuacgggccaagggacauucucagguagacaguuucuauggggcguaggccucccaaaagguaacggaggcgugcaaagguuuccucgggccggacggagauuggcccucgagugcaaaggcagaagggagcuugacugcaagacccacccgucgagcagggacgaaagucggccuuagugauccgacggugccgaguggaagggccgucgcucaacggauaaaaguuacucuagggauaacaggcugaucuuccccaagaguucacaucgacgggaagguuuggcaccucgaugucggcucuucgccaccuggggcuguaguauguuccaaggguugggcuguucgcccauuaaagcgguacgugagcuggguucagaacgucgugagacaguucgguccauauccggugugggcguuagagcauugagaggaccuuucccuaguacgagaggaccgggaaggacgcaccucugguguaccaguuaucgugcccacgguaaacgcuggguagccaagugcggagcggauaacugcugaaagcaucuaaguaguaagcccaccccaagaugagugcucuccua .............<<<<<<<<<<.....<<..<<<<<<<<<<<.<......<<<<<<.....((.>>>.....<<<<<<<..<<.))......>>.....>>>>>>>...>>>....<<<....>>>......<<<<<<<<.........>>>>>..>>>.>....<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<....<<<<....>>>>......<<<<<<<<<....<<<<...<<<.<<<<.<<<...<<.<<.....>>.>>((......<<<.....))>>>...>>>...>>>>.>>>..>>>>.>>>>>>..>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..>>>......>>.>>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>........<<<<..<<<<.......>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<...<<<...<<.......>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>..<<.<...<<<<<<.....<.<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>.>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<.<<<<<<<....<<<<<<.....<<<...<<<<<<<<...<<<<<........>>>.>>...>>>>>>>>..>>.>.....>>>>>>..<<<<<<.........>>>>>>..>>>>>>>..>>..<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<<.........<<<.<<....<<.........>>....>>.........<<......>>...>>>.....>>>>>>>>>>.>>..........))).....>>>>>>.>>>...>>>>>>><<<<<......>>>>>....>>>>>><.<<<<<<...........<<<<<.<<....>>>>>>.>.......>>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<.<<<<.<<<<.<<<<....<<<<..<<<..<<<<<<<<<<.....(((..>>>>>....<<<<<...<<<.<<<<<<.....>>>>>>.....<<<<<<.......>>>>>>..>>>..>>>>>.....<..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>>>....>>>>..>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<<<<<<.....>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<..<<<<<<..<<<<....>>>>...>>>>>>..>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<..<......<<<<.<<<<<<..<<<<<..<<<<<<<..<<.<<<.<<<<<<<<..............<<<..<<<......<<<<<<.......>.>>>>>...>>>............>>>.....>>>>>>>>.>>>.>>...<<<<<.<<<..........>>>>>>>>.....>>>>>>>...>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<..<<<<<<<.......>>>>>>>....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..>>>>..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<...<<<<..<<<<<<<<........>>>>>..>>>.<<<<<.....>>>>>.....>>>>.......>>>>>.....<<<<<<<....>>>.>>>>....>...>>>>>>>>>>>....<<<<<<<...<.<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>...>>>>>...>>>>.>>>>>..<.<<...<<<<<<...........>>>>>>...>>>.>>.>.......>>>>>>>.... .............(((((((((......((..(((((((((((.(......((((((..[..[[[)))...].((((((...(((]]..]..)))......))))))...)))....(((....)))......((.(((((.........)))))...)).)....((((((.....(...[..)......))))).).........((....))...((((......((.]...)).....))))...((([...(((......)))....(.(((.(((((.(..((((...(.(.((((.(((...((.((.....)).))[[(...).(((.....]])))...)))...)))).).)..))))))))))...)))]....(((((((...[.......)))))))....).(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((....))))............)......)))))))))......(.((((..((((.......))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.......))...)))...((....))..((((.....))))....)))))))))))))..((.(...((((((.....(.((((((((.((((...(((..(......)..)))...)[)))...(((.(((((.......<))))))))..).))))))).).(.(((....[)))...).]))))))......).))..((((((....(((((....)))))((.(((((((....((((((.....(((...(((((((.(..((...............))..).)))))))..)).).....))))))..((((((.........))))))..)))))))..))..((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((.((((((.....{...(((.(((...((.........))...))).....(...((......)).).))).....)))))).))).))..........]]].)...))))))))))...)))))))(((((......)))))....))))))(.((((((....(......(((((.((....)))))).)...)...))))))..).....))))))(......((.....((((((.......))))))((((....(((...((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((.(((((((((.((((....((((..(((..(((((.((((.....{{{..)))).(...((((....(((.((((((.....)))))).....((((((.......))))))..)))...))))....)(..(((((....)))))...))))))...)))...))))(..).....))))...))))...)))))..))))))))).))).....((......))..))).((((.....))))..))))..((((....(((((((..((..(....(.......(((((....(.{..).....)))))(((((((.....)))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((..((((((..((((....))))...))))))..))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..)))..))))))).)))))).....)).{..(((((.....].})))))..((((((((.(((..(......((((.((((((..(((((..(((((((..((.((..((((..((..(...........(((...((........(...(......)...).....)).............)))..)..).).))))..)).))...(((((.(((..........)))))))).....)))))))...)))))..(((.(...)[)))((((((..........]))))))(.((...(((((((.(((((((.........))))))..).((.[.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..)))))).......((((.(.((((((...((.......))...))))))...)))).)........((((.(.((((..((((((((........)))))..))).(((((.....))))).....))))...)...))))......(((((((....))).))))..>.)...)))))))))))[...(((((((...(.((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))...)))))...)))).)))))..(.((....((((.....}.......))))....))).)).)..]....))))))).... Structure of the 50S large subunit of chloroplast ribosome from spinach; 23S rRNA 5xjc B 84 3.6 RF00020 URS000075BAAE_9606 28502770 0000244,0000353 0005682,0046540 9606 gguuucucuucagaucgcauaaaucuuucgccuuuuacuaaagauuuccguggagaggaacaacccaauuuuuugaggccuugc .<<<<<<<<<<<........<<<<<<<<...........>>>>>>>>...>>>>>>>>>>>....................... .(((.(((((((....(...((((((((.(.......).)))))))).).))))))).)))....................... Cryo-EM structure of the human spliceosome just prior to exon ligation at 3.6 angstrom; U5 snRNA 5xjc F 97 3.6 RF00026 URS00001EC8D7_9606 28502770 0030621 0000244,0000353 0005688,0046540 9606 gugcucgcuucggcagcacauauacuaaaauuggaacgauacagagaagauuagcauggccccugcgcaaggaugacacgcaaauucgugaagcguu <<<<<.<<<..>>>>>>>>.....................................<<...<<<.....>>>....>>................... (((((.((....))))))).....................................((..((((.....)))..).))................... Cryo-EM structure of the human spliceosome just prior to exon ligation at 3.6 angstrom; U6 snRNA 5xjc G 84 3.6 28502770 10515 ggaaacggccuccgaacgguaagagccuagcauguagaacugguuaccuccaggguuuccuugaugaugucauacuuauccugu .................................................................................... .................................................................................... Cryo-EM structure of the human spliceosome just prior to exon ligation at 3.6 angstrom; pre-mRNA 5xjc H 140 3.6 RF00004 URS00003EE995_9606 28502770 0045131 0000348 0005686 9606 aucgcuucucggccuuuuggcuaagaucaaguguaguaucuguucuuuuaauaucguccucuaccgaggacaauauuaaggauuuuuggagcagggagccacgcaucgaccugguauugcaguaccuccaggaacggugc ...............................................<<<<<<<.<<<<<<....>>>>>>.>>>>>>>...............<......><<<<<<.<<<<<.............>>>>>..>>>>>> ...............................................(((((((.((((((....)))))).)))))))...............(..()..)(((.((.(((((.............)))))..)).))) Cryo-EM structure of the human spliceosome just prior to exon ligation at 3.6 angstrom; Homo sapiens small nuclear RNA (U2) gene 5xwg A 15 3.002 URS0000BC468B_32630 28898762 32630 cgcuncgaaaaaguc ............... ............... Crystal structure of a novel RNA motif that allows for precise positioning of a metal ion; RNA (5'-R(P*CP*GP*CP*UP*(5BU)P*CP*GP*AP*AP*AP*AP*AP*GP*UP*C)-3') 5xwp C 58 3.086 URS0000BC469D_32630 28757251 32630 gaccaccccaaaaaugaaggggacuaaaacacaaaucuaucugaauaaacucuucuuc .....<<<<.........>>>>.................................... ....(((((.........))))..)................................. Crystal structure of LbuCas13a-crRNA-target RNA ternary complex; RNA (59-MER) 5xwp D 30 3.086 URS0000BC467E_32630 28757251 32630 ggaagaagaguuuauucagauagauuuguc .............................. .............................. Crystal structure of LbuCas13a-crRNA-target RNA ternary complex; RNA (30-MER) 5xwp E 58 3.086 URS0000BC469D_32630 28757251 32630 gaccaccccaaaaaugaaggggacuaaaacacaaaucuaucugaauaaacucuucuuc .....<<<<.........>>>>.................................... ....(((((.........))))..)................................. Crystal structure of LbuCas13a-crRNA-target RNA ternary complex; RNA (59-MER) 5xwp F 29 3.086 URS0000BC467E_32630 28757251 32630 ggaagaagaguuuauucagauagauuugu ............................. ............................. Crystal structure of LbuCas13a-crRNA-target RNA ternary complex; RNA (30-MER) 5xxb 1 3077 3.17 RF02540,RF02543 URS0000BC46A5_5811 28809395 0003735 0005840 5811 agaccugaaaucaggcgagguuacccgcugaacuuaagcauauuauuaagcggaggagaagaaaauaacuaugauucccuuaguaacggcgagugaaccgggaucagcucaaaguggaaaucaacugcucuguugacuuguagccucgagaggcguuaccaguggaagcgcaggguuaaguuucuugggaaagaacaucauagagggugagaaucccguccuuccccugcguuuuuuguuccacguacgguacgcuuuuauagagucgcguucaucgggauuugagcgcaaaaugugugguagguuucacauaaagcuaaguacuggcgcgagaccgauagcaaacaaguaccgugagggaaagaugaaaaguucuuuggaaagagaguuaaaagugccugaaauugcugaaaaggaagcgauugggaccuugauuccaagaagugccgccgguuugccaucuaucccuuugccuucucucucucaccagguuuaggcuuugucuugauguauuuccgguucaucuuuuuggagaggucagcaucagcuacucggaauugauuucguucaaagaagguagguuccuuguggaccguuauaucuuuguucuuuccuuuuccuuguggcugaggaguguuccuguuuccgagcucgguuucugugaugcuggcuaucgguuccaaccgacgucuugaaacacggaccaaggagucuaacauaugugcgaguacggguuuuacuccuguaugcgcaaugaaagugaaguagggagauuuugcuuugccauucuucgcaccuacgaccgaccacgaucucugagagagguuugaguuggagcauaucuguuaggacccgaaagauggugaacuaugccugaguagaaugaagucagggccugauggagguucguagcgauacugacgugcaaaucguucgucaaacuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuucuuccgaaguuucucucaggauagcuggaguuuuguuaguuuuaucagguaaagcgaaugauuagaggcccucgaccuauucucaaacuuuaaauggguaagauccagugguuacuucauugaacugcugggauuaauaugacuccaagugggccauuuuugguaagcagaacuggcgaugagggaugcuccuaacgcuugguuaaggugccaaaaugcucgcucaucagauaccauaaaagguguugguucauaugaaccagcccugaaaauggauggcgcugaagcgggcuaccgauaccaggccauugcuacuaauuaucacucgaccuuuuguagcaaugaguaggaagacguggggauugugacgaagcguucggcguaagccugcguggaacagucucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggagaaggguuccaugugaacagcaauuggacauggguuagccgguccuaagcgacagcuuaacugcguauacaguaccucguuucgcgaaagggaaucggguuaauauucccgagccaggacguggauacuguacgguaacguaagugaacuccucgacgcaggcaggugcuccgggaagcguugucuuugcuuuuuaacagccacccuggaaucaguuuagcuggagauaggguuagcuggcugguagagcaccuuggaagguguccggugcgcuccugacugcccuugaaaagaggagggaaaguuguuauuuacaccccuggccguaccaauaaccgcaucaggucuccaagguuaguagccucuggucgauagaauaagguagauaagggaagucggcaaaauagauccguaacuucgggaaaaggauuggcucugagggcuggaacagcuaacucagaacuggagcggacaaggggaauccgacuguuuaauuaaaacaaagcauugcgauggccauaacugguguugacgcaaugugauuucugcccagugcucugucaaugugaugaaauuaaucaagcgcggguaaacggcgggaguaaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguccgacuuugugaaauuuacuuauuccguuaaguugagacucaugcucugcauguguuuugguuuuaagguggcccgcugaucuacgcggaagacacagucagguugggaguuuggcuggggcggcacaucugugaaacaauagcgcagguguccuaaggcaagcucaaugagaacagaaaucucauguugaccaaaaggggaaaagcuugcuugauuuugauuuucaguacgaauacaaacugugaaagcauggccuaucgauccuuuaggucugagaaacuuucagcuagaggugucagaaaaguuaccacagggauaacuggcuuguggcagccaagcguucauagcgacguugcuuuuugauccuucgaugucggcucuuccuaucauugagacgcagaagucucaaagugucggauuguucacccgccaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugacuugauacugcgacaguaauccaacuuaguacgagaggaacaguugggucggauacuugguaaaugcggcuagcugaaaagcuagugccgcgacgcuaccauccguuggauuaugacugaacgccucuaagucagaauccaugcuggauaugcaguguuauucaccgccuccuuuguuucaugcaaugauacaggccucuggccugcuucucaucaaagcccugggcgagaaucucaauuucuaacauuggaggugauacauccauugcagacgacuuuguugcaaccggguauuguaaguaugagaguaggcuugucuacgaucuacuaagauuuuuccugcguuguucgaugugg 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.......................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........((((((......)))))....)..........((((.(((..((((((((((((((....({((((......)))))[[(...).(((....}]]))).......)))))))))......))))).....)))))).).....)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))...........).....................((.((((((((.....(((((((((.....(((...(....(......(....(((...((.(......)))...)))....).....)...)...).)).....)))))))))..(.(((((((.((((((..((((..(.....(..((((((.....((((.......))))......))))))..)....)..))))..)))))).).[[[[......(...((((..))))...).....)))))).)...)))))))).)).<((........))..((((((..(.((((((.((((((..(((.(((.......)))...)))...((....))...(((((..((....((...))......))...)))))((((((((.(..((...))..).)).))).)))...)))))).))))))..((.(...((((((.....(((((((((..((((...((((((.))))))...)<)))...(((..((.((........)))).)))....))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)(((((((.(....((.(((((((.....(((....(((..(.(((.......))).)..)))..)).).....)))))...(((((((((.(......))))))))))....))))..)))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((....)))))))))))..........]]].)....))))))))))...)))))))(((((((((........]]]]........)))))))))....))))))(.((((((((((......((((..(((....))).))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((((..((......)).......(..)......))))....))...(((((........)))))]]((((..(((((((....(((....)))...(.[.((((((...((((.((((.(((((((((((((...{{..))))))(...((((((((((.....(((.....))).....))))).....)))))....)((((((....)))))))))).).)).)))).))))(...)....))))))...)......))))..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.[..).....)))))((.((((((((((.....))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((....))))......))))))).].(((.(((..((((((.((.....(.(......)).....))..))))..)))))(((((......)))))........(...........(((((.......))))).....)....)))....)).))))))).)..))).)))))))).))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.(((.((((..(((((.)))))...(((((.....(.((..(...............).........]..((((...))))..)).)..))))).....)))).)))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....(((((.(.((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(((((((((......))))))..))).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))....))..))).))))).....((((((((..((((.(((((((......(....).....)))))))(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.............))))...)))).)))).....))))))))......((.((((..(.((.......(.......(((.....)))....)...........((..)).................)).)..)))).))..(((((((..(.......)..))..(((((((((.(((....(((.((..((((.(..).))))..)))))...)))....)))).)))))..))))).. Large subunit of Toxoplasma gondii ribosome; 25S RNA 5xxb 3 118 3.17 RF00001 URS000022106C_5811 28809395 0003735 0005840 5811 gcugucggucauacugcgucgaauacaccggaucccuucagaccuccgaauuaagcggcgcaaggcccgguuaguacuugggugggggacucccagggaauaccgggugcugacagcu <<<<<<<<.....<<<<<<<<.....<.<<<..............>>>..>....>>>>>>.>><<<<<<<.....<<<<<<.<<....>>>>>>>>....>>>>>>>.>>>>>>>>. (((((((((....((((((((.....(.((((...(....)...))))..)....)))))).))((((((......((((((.((....)))))))).....))))))))))))))). Large subunit of Toxoplasma gondii ribosome; 5S RNA 5xxb 4 157 3.17 RF00002 URS00001D5B7A_5811 28809395 0003735 0005840 5811 aaauuuucagcaauggaugucuuggcucgcgcaacgaugaaggacgcagcgaacugcgaaacgcaaugugaauugcagaauucagugaaucaucagauuucugaacgcaaauggcaccuugggguauucuccuugguacgucuguuucagugucuuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<..<<<<....>>>>..>>>.................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((..((.(....).))..))).................... Large subunit of Toxoplasma gondii ribosome; 5.8S RNA 5xy3 1 2544 3.2 RF02540,RF02543 URS000029F830_5722 28809395 0003735 0005840 5722 guagucugccauacgcaggaagacccgcugaacugaagcaucucauuaagcggaggaaaagaaacuaacuaggauucccuuaguaaaggcgaucgaaaagggaacagcccaacgucuuaaucccgagggaaauguagucgguucaccuauugcacuggucuaagucagauggaaugcugcgcgauucagaguaaaagccucguaugaccaaccgcaagcuuacgauggaccggggagagucggauacuuugagaguagugucuuaagggggugguaugucccauccaaggcuaaauaacgugagagaccgauagauuacaaguagugugaacgaaagaugaaaagaacucuaaaacagagggugaaaaguuccugaacuugcuuaggguuaaggcuauuuauaguacccgucuugaaacacggauuagggaguuuaucuguagugcgagucuuugcacguuaacuguaaaggcguagagaaagcaacuggcguuugcauggcuacugagcauuacugauaggacccgaaagguggugaacuuugccugcacagguugaagucaggggaaacucugauggaggaccguacggguuauugaugugcaaaucauuuuucugauguagguaaaggugcgaaagacucaucgaaccaccuaauagcugguuuccuccgaaguuucccucaggauagcuguaaugcuaguuaaggggaguagaguauggguagagguacuuauuuccaaacuucgaaccuccuuguuaggcauuuaccuaacuggaaaugcuuaaaugaauuagcguuacaagugggcucugaccgguaagcggucauggcgaaaugggaugaaccauacgucugaauaaggugccgaaauguacuaucacugauaccauaaagggaguccauguauauacuagggccccgaaaaugaauggcgcauauaguacuaccgaucucagacaucaguucuauugaacugagaguagggggauguggacauuuuugugaaggugcaaugugaguuggacuggaagaaugucuauuacagauccuaauugaaguagcgauuauccaggcuuguauccugggggcugaugaggaguaggguuucuggacaacuuaaacagauccagaguuagucgauccuaaucucaauaaugggagaaagggaguacaguugauauucuguaacugacaacaguucgcggcaacgcauacuauuuuucuccgccaaucuuauaccguugguagggaucucuuuccuacaugacaguacuaauacccagggaaacuggucaucaggcgaacugcggcguucugcuggcaaaacauagcuguuaugucaauggcuauuggauugguccaugaagcgaaaaauaguuuacuggucacucguaccgauaaccgcaucaggucuucuagguaaguagccuauggccauugaggcaugauaguucagggaauucggccaauuagagcuguaacuucgggauaaagcuuggcucugaugaaaaucagaaccgauuguuacgcggagagcccaacuguuuaauaaaaacguagugucgcgcugugguaguauagccagugaacgcgacaugaauccugcucagugcugugucuguuaauaugguucaagccaacgaagcaccgguaaauagcugggguaacuaugacucuuaucaaaguagcgaaauaccucgucacuuaauuagugaccugcaugaacggagcuaugagguucucacugucccaaacugucucucagcgaaccaacuguagugggaacggucacuagauauccagcggggaaagaagacccuguagagcuucacuuuggucuagucuuguauaguauuaugcuuaccuaucacaaggaauaggacuagauagaaaguuuggcuggggcggcacaccuucgaaagagcagcgaagguguccuaaguugagcucagugaggacagaaaucucacguugaggauaaggccaaaagcucaauuuacugugccuuuuuguacuaggaucaguuacgaaaguaaggccuaacgaucccuaaauagccucaggugcgugaggauuggggugacagacaaguuaccuccgggacaacuggcuuguggcugcuaagagaucaaaucaacgcagcuuuuugauucuucgaugucggcucuuccuauccuagugauguacaaguugcuaagggucggauuguucacccguauuagggaucgugagcuggguuuagaccgucgugagccagguuuguuuuauccuacuggauauagcaucaugauaguagauugauuuaguacgagaggaacuguugauuauggccucugguuagcgauuaucggaaacgguaugucgcgcagcuacgccgucugggauaauggcugaaagccucuuaagccagaagcccaucuagaaagugaugcacuacgaauaaugguaacccaauguagaagacauugugugaacgaagguacuguaagcaguggaguggcaccacgaccuguugagguucagcuucgcuucuagguuuc 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.......................(((((......(...[..).......)))).).........((....))...((((.......(.]...)......))))...((((......(..(((((..))))....))..(((((((.(..((((..(((((...(.(((........))))[[(...).(((.....]])))....)))))...))))......).)))))))....)....(((((((........))))))).....(((((..[[[[[[)))))..))).................................((....))............(..((((.....))))...........).....................(((((..))))).<((((........))))((((((....(((((.(((((((..(((...(((.......)))...)))...(......)...((((....)).))........))))))).)))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))....((...((.((........))))..))....))))))))).(..(.......)....)..))))))......).))..((((((....(.(((....))).)((((((((((.(.((((((((....(((..((...(.(((()))).)...))..)).)....)))))).((((((((((.((.....))))))))))))...)))..)))))))).))..(((.((((((.....)))))).)))....(((......)))...((((((....((([[[...(.((((((....((..........(((.((((..(((..)))..)))))))..........]]].))..))))))))))....)))))).(((((((....))))))).....))))))(.((((((((((......(((.((((....)))).)))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...((((((...((.....)).)))))).....[(((.((...((((......))))....))...(((((........)))))]..(((..((((..(((....)))..((((((((((...((((((((.(((((.(((((((((...{{..))))))....(((.(...((.(((((.....(((.....))).....))).)).))..).))).....(((((((.)))))))))).)).))).))))))))(...)....))))))))))..)))))))..)))..)).....((......)).)))).((((.....))))..))))..((((....(((((((..((..(....(.......(((((....(.{..).....)))))((.((((((....)))))).))............(((((((((.].((.........))...(((((((....((((......))))......))))))).}.(((.(((..((((((.((..((.....((((....)))).....))))))))..))))).((((.........))))..........((..........(((((.......)))))..)..)....)))....)).))))))).)..)))..))))))).))))))....))[[..(((((.....>]])))))...((((((..(((.((......((.(.((((((..(((((.(((((((((.(((((.().)))))...(((......)))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...(((..(((.........)))..))).(((....))).))]]].].....((((.....((((.]].]]]]))))..))))....).....))))..))).)).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(((((((((......))))))..)))..((.(.....).)).....)))))..)...))).).....(((((.(....).).))))....))..))).))))))...((((((...(((..(((((((......(....).....)))))))(((((...((((..((((((((((}}..))))).)))))...)))).)))))..(((....((((..............))))....)))..))).....))))))...............(((((((((.......)))))...(((((((.(.(((....((((.(..((((..))))..)))))...)))....))))).)))..)))).. Large subunit of Trichomonas vaginalis ribosome; 25S ribosomal RNA 5xy3 3 117 3.2 RF00001 URS00000C225A_5722 28809395 0003735 0005840 5722 gaagcggccacacccggcuggcaacauccagcuccacuccgaaccuggaaauuaagcagucgcgggccacaucaguacugggcugggcgacuucccgggaacgugcggugcuugcuu <<...<<.....<<<<<<<<.....<<<<<<.............>>>>..>>....>>>>>>.>><<<.<<<.....<<<<<..<<....>>.>>>>>....>>>.>>>.>>...>> .(...(.(....((((((((.....((.(((...(.....)...)))...))....)))))).))(((.(((.....(((((..((....)).)))))....))).)))).)...). Large subunit of Trichomonas vaginalis ribosome; 5S ribosomal RNA 5xy3 4 154 3.2 RF00002 URS0000527ECE_5722 28809395 0003735 0005840 5722 aagucucuaagcaauggaugucuuggcuccucacacgaugaagaacguggcauaauguguuaaguaaccggaguugcaaacaucaugacagguuaaucuuugaaugcaaauugcgcuaaacucgaucgagaagcaugggugugacaguacuaca ..........................................<<<.<<.((.....>>......<<<<<......)).............>>>>>...>>>....<<.....>><<<...<<<<..>>>>.>>>.................... ..........................................((((((.[[....[)))...].((((((..(..]]...).......).)))))...)))....((.....))(((...((((..)))).))).................... Large subunit of Trichomonas vaginalis ribosome; 5.8S ribosomal RNA 5xym A 2665 3.08 RF02540,RF02541 URS00003A7753_246196 28875450 0003735 0005840 246196 aguguuuaagggcgcaugguggaugccuuggcacugggagccgaugaaggacguaggaggcugcgauaagccucggggagcugucaaccgagcguugauccgaggauguccgaauggggaaacccggcacgagugaugucgugucaccaggcgcuaauauauaggcgucuggggggaacgcggggaagugaaacaucucaguacccguaggaagagaaaacaaaaugugauuccgugaguaguggcgagcgaaagcggaggauggcuaaaccggcgggguugugggaugguuagcggaaauggcuugggauggccugccguagacggugagagcccgguacgugaaaacccgaccccgaguagcagcgggcccguggaaucugcugugaaucugccgggaccacccgguaagccugaauacuucccagugaccgauagcggauuaguaccgugagggaauggugaaaaguaccccgggaggggagugaaagaguaccugaaaccgugcgcuuacaauccgucagagcccucgacuggggugauggcgugccuuuugaagaaugagccugcgagucagggacaugucgcgagguuaacccgggugggguagccgcagcgaaagcgagucugaauagggcguauccacacaagagugugugguguagugguguguucuggacccgaagcggagugaucuacccauggccagggugaagcgcggguaagaccgcguggaggcccgaacccacuuagguugaagacugaggggaugagcuguggguaggggugaaaggccaaucaaacuccgugauagcugguucuccccgaaaugcauuuaggugcagcgucgcauguuucuugccggagguagagcuacuggauggccacgucagccaaacuccgaaugccgguaaguccaagagugcggcagugggacggcgggggauaagcuccgugcgucgagagggaaacagcccagaucgccggcuaaggccccuaagcgugugcuaaguggaaaaggaugugcagucgugauugugcgccgauaauguagcggggcucaagcacaccgccgaagccgcggcagccaauuggcuggguaggggagcguccugcauccggugaagccgccgagugaucgagugguggagggugugggagugagaaugcaggcaugaguagcgauuaggcaagugagaaccuugcccgccgaaagaccaaggguuccugggccaggccaguccgcccagggugagucgggaccuaaggcgaggccgacaggcguagucgauggacaacggguugauauucccguacccguguagcgauggggugacgcaggaagguagccguaccggucaggguaauaccgggguaagccuguagggagucgauagguaaauccgucuggcauccugagaggugaugcauagccgcgaauucggugauccuaugcugccgagaaaagccucuagcgacacggcccguaccccaaaccaacacagguggucagguagagaauacuaaggcguacgagugaacuaugguuaaggaacucggcaaaaugcccccguaacuucgggagaagggggacccacauggcguguaagcgugaguggguggcacaaaccagugagaagcgacuguuuacuaaaaacacagguccgugcgaagucgcaagacgauguauacggacugacgccugcccggugcuggaagguuaagaggacccguuaacugugaagcggagaauuuaagccccaguaaacggcggugguaacuauaaccauccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaacgacuucucaacugucucaaccauagacucggcgaaauugcacuacgaguaaagaugcucguuacgcgcggcaggacgaaaagaccccgggaccuucacuacaacuugguauuggugcucgagggccucuaaccucggaccguaauccgguucagggacagugccugguggguaguuuaacuggggcgguugccuccuaaaauguaacggaggcgcccaaagguucccucaaccuggacggcaaucagguguugaguguaagugcacaagggagcuugacugcgagacggacaugucgagcagggacgaaagucgggacuagugauccggcaccucugaguggaaggggugucgcucaacggauaaaagguaccccggggauaacaggcugaucuuccccaagaguccauaucgacgggaugguuuggcaccucgaugucggcucgucgcauccuggggcuggagcaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguuuagaacgucgugagacaguucggucucuauccgccgcgcgcgucagaagcuugaggaaaccugucccuaguacgagaggaccgggacggacgaaccucugguauaccaguugucccaccaggggcacggcuggauagccacguucggacaggauaaccgcugaaagcaucuaagcgggaaaccucuuccaagaccaggcuucucacccucuaggagggauaaggccccccgcagaccacgggauugauagaccagaccuggaagccuaguaauaggugcagggaacuggcacuaacggccga 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.........((((((((((.....(((..(((((((((((((......((((((.[...[[.))).....((((((...(((]]....].)))......))))))...)))....(((....)))(((((((......))))))).(((((((((........))))))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))....(((....((...))....(.((...((...(((...(.((((......)))))[[(...).(((.....]])))...)))......))....)).....(((((((...[.......)))))))....).(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((..(((((.....)))))..)))).<.(.(........).).((((((....(((.((((((((((..(((...(((....)))...)))...((....))..((((.....))))....((((((.(...)))))))....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([.((((((((.....(((....(((.((((...)))).)))..)).).....))))))))....).]))))))).))..((((((((((......)))))).))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((.(..).)))))).))...........]]].)....))))))))))...)))))))((((((()))))))....))))))(.((((((((((......((((((((....))).)))))...))))))))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]]((((((.((...(((((...((((..(((..((((..(((((...{{{...))))).((..(((....(((..(((...((.....))..).))...)))....)))...)).............))))...)))...))))(..)....)))))..)).)))))))))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((...((((....))))..))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((....((((..(...)...))))....))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....))[[..(((((.....>]])))))..((((((((.(((.((......((((((((((..(((((.(((.(((((.((.((((..)))).))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.(.((((...((.......))...)))).)...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))....((....((((.............))))....))..))))..]....)))))))..(((((..).))))....((((.((((.......)))).....(((.((((.(((....(((((....)))))...)))..))))..)))..)))).. Large subunit of Mycobacterium smegmatis; 23S RNA 5xym B 116 3.08 RF00001 URS000047BBB1_246196 28875450 0003735 0005840 246196 uuacggcgguccauagcggcagggaaacgcccggucccaucccgaacccggaagcuaagccugccagcgccgaugauacuacccuuccggguggaaaaguaggacaccgccgaaca ...<<<<<<<.....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<.......<<<<<<....>>>>>>.......>>..>>>>>>>.... (..(((((((.....((((((((......(((((...(.....)...))))..).....)))))).)).((.......((((((....)))))).......))..))))))).).. Large subunit of Mycobacterium smegmatis; 5S RNA 5xz1 A 22 3.008 URS0000D77917_32630 32630 ugcgucgcuccggaaaagucgc ...................... ...................... Crystal structure of the Homo Sapiens cytoplasmic ribosomal decoding site in complex with G418; RNA (5'-R(*UP*GP*CP*GP*UP*CP*GP*CP*UP*CP*CP*GP*GP*AP*AP*AP*AP*GP*UP*CP*GP*C)-3') 5xz1 B 22 3.008 URS0000D77917_32630 32630 ugcgucgcuccggaaaagucgc ...................... ...................... Crystal structure of the Homo Sapiens cytoplasmic ribosomal decoding site in complex with G418; RNA (5'-R(*UP*GP*CP*GP*UP*CP*GP*CP*UP*CP*CP*GP*GP*AP*AP*AP*AP*GP*UP*CP*GP*C)-3') 5xz1 C 22 3.008 URS0000D77917_32630 32630 ugcgucgcuccggaaaagucgc ...................... ...................... Crystal structure of the Homo Sapiens cytoplasmic ribosomal decoding site in complex with G418; RNA (5'-R(*UP*GP*CP*GP*UP*CP*GP*CP*UP*CP*CP*GP*GP*AP*AP*AP*AP*GP*UP*CP*GP*C)-3') 5xz1 D 22 3.008 URS0000D77917_32630 32630 ugcgucgcuccggaaaagucgc ...................... ...................... Crystal structure of the Homo Sapiens cytoplasmic ribosomal decoding site in complex with G418; RNA (5'-R(*UP*GP*CP*GP*UP*CP*GP*CP*UP*CP*CP*GP*GP*AP*AP*AP*AP*GP*UP*CP*GP*C)-3') 5y6z B 15 2.5 URS0000CBFF52_32630 29164396 32630 caggucucucgucga ............... ............... Crystal structure of the coxsackievirus A16 polymerase elongation complex; Template RNA (33-MER) 5y6z C 12 2.5 URS000080DF73_32630 29164396 32630 uucgacgagaga ............ ............ Crystal structure of the coxsackievirus A16 polymerase elongation complex; Product RNA (14-MER) 5y6z F 18 2.5 URS0000CBFF52_32630 29164396 32630 ggaggucucucgucgaaa .................. .................. Crystal structure of the coxsackievirus A16 polymerase elongation complex; Template RNA (33-MER) 5y6z G 12 2.5 URS000080DF73_32630 29164396 32630 uucgacgagaga ............ ............ Crystal structure of the coxsackievirus A16 polymerase elongation complex; Product RNA (14-MER) 5y85 A 18 2.001 URS0000CBFF44_256318 29081514 256318 acccgcaaggccgacggc .................. .................. Structure-based Insights into Self-Cleavage by a Four-way Junctional Twister-Sister Ribozyme; RNA (5'-R(P*AP*CP*CP*CP*GP*CP*AP*AP*GP*GP*CP*CP*GP*AP*CP*GP*GP*C)-3') 5y85 B 50 2.001 RF02681 URS0000CBFF28_256318 29081514 0003824 256318 gccgccgcuggugcaaguccagccacgcuucggcgugggcgcucaugggu ......<<<<<.......>>>>><<<<<....>>>>>............. ......(((((.......)))))(((((....)))))............. Structure-based Insights into Self-Cleavage by a Four-way Junctional Twister-Sister Ribozyme; DNA/RNA (50-MER) 5y85 C 18 2.001 URS0000CBFF44_256318 29081514 256318 acccgcaaggccgacggc .................. .................. Structure-based Insights into Self-Cleavage by a Four-way Junctional Twister-Sister Ribozyme; RNA (5'-R(P*AP*CP*CP*CP*GP*CP*AP*AP*GP*GP*CP*CP*GP*AP*CP*GP*GP*C)-3') 5y85 D 50 2.001 RF02681 URS0000CBFF28_256318 29081514 0003824 256318 gccgccgcuggugcaaguccagccacgcuucggcgugggcgcucaugggu ......<<<<<.......>>>>><<<<<<..>>>>>>............. ......(((((.......)))))(((((....)))))............. Structure-based Insights into Self-Cleavage by a Four-way Junctional Twister-Sister Ribozyme; DNA/RNA (50-MER) 5y87 A 18 2.132 URS0000CBFF44_256318 29081514 256318 acccgcaaggccgacggc .................. .................. Structure-based Insights into Self-Cleavage by a Four-way Junctional Twister-Sister Ribozyme; RNA (5'-R(P*AP*CP*CP*CP*GP*CP*AP*AP*GP*GP*CP*CP*GP*AP*CP*GP*GP*C)-3') 5y87 B 50 2.132 RF02681 URS0000CBFF28_256318 29081514 0003824 256318 gccgccgcuggugcaaguccagccacgcuucggcgugggcgcucaugggu ......<<<<<.......>>>>><<<<<....>>>>>............. ......(((((.......)))))(((((....)))))............. Structure-based Insights into Self-Cleavage by a Four-way Junctional Twister-Sister Ribozyme; DNA/RNA (50-MER) 5y87 C 18 2.132 URS0000CBFF44_256318 29081514 256318 acccgcaaggccgacggc .................. .................. Structure-based Insights into Self-Cleavage by a Four-way Junctional Twister-Sister Ribozyme; RNA (5'-R(P*AP*CP*CP*CP*GP*CP*AP*AP*GP*GP*CP*CP*GP*AP*CP*GP*GP*C)-3') 5y87 D 50 2.132 RF02681 URS0000CBFF28_256318 29081514 0003824 256318 gccgccgcuggugcaaguccagccacgcuucggcgugggcgcucaugggu ......<<<<<.......>>>>><<<<<....>>>>>............. ......(((((.......)))))(((((....)))))............. Structure-based Insights into Self-Cleavage by a Four-way Junctional Twister-Sister Ribozyme; DNA/RNA (50-MER) 5y88 B 117 3.46 RF00020 URS000053F313_559292 28919079 0000244,0000353 0005682,0046540 559292 ggaggucaacaucaagaacugugggccuuugccuauagaacuuauaacgaacaugguucuugccuuuuaccagaaccauccggguguugucuccauccauauuuuuuggaacuuuuc <<<<<.<<<<<<<.....<<<<<<<<....>>>>>>>>..............<<<<<<<<...........>>>>>>>>...>>>>>>>>>>>>....................... (((((.(((((((.....((((((((....)))))))).........((...((((((((.(.......).)))))))).))))))))))))))....................... Cryo-EM structure of the intron-lariat spliceosome ready for disassembly from S.cerevisiae at 3.5 angstrom; U5 snRNA 5y88 D 101 3.46 RF00026 URS00006184A9_559292 28919079 0030621 0000244,0000353 0005688,0046540 559292 guucgcgaaguaacccuucguggacauuuggucaauuugaaacaauacagagaugaucagcaguuccccugcauaaggaugaaccguuuuacaaagagauu <<<<<<<<<<.....>>>>>>>>>>.....................................<<<..<<<.....>>>...>>>................. ((((.(((((.....))))).)))).....................................(((.((((.....)))..))))................. Cryo-EM structure of the intron-lariat spliceosome ready for disassembly from S.cerevisiae at 3.5 angstrom; U6 snRNA 5y88 E 28 3.46 28919079 559292 guauguauuuauuuuuagauacuaacac ............................ ............................ Cryo-EM structure of the intron-lariat spliceosome ready for disassembly from S.cerevisiae at 3.5 angstrom; Intron lariat 5y88 F 82 3.46 RF00004 URS000023C730_559292 28919079 0045131 0000348 0005686 559292 acgaaucucuuugccuuuuggcuuagaucaaguguaguaucugacauuuuuuggcaccgcgacccucgcacuuguggagucg .........................................................<<...<<...........>>...>> .........................................................((...(.............)...)) Cryo-EM structure of the intron-lariat spliceosome ready for disassembly from S.cerevisiae at 3.5 angstrom; U2 snRNA 5ylz B 117 3.6 RF00020 URS000053F313_559292 29153833 0000244,0000353 0005682,0046540 559292 ggaggucaacaucaagaacugugggccuuugccuauagaacuuauaacgaacaugguucuugccuuuuaccagaaccauccggguguugucuccauccauauuuuuuggaacuuuuc <<<<<.<<<<<<<.....<<<<<<<<....>>>>>>>>..............<<<<<<<<...........>>>>>>>>...>>>>>>>>>>>>....................... (((((.(((((((.....((((((((....)))))))).........((...((((((((.(.......).)))))))).))))))))))))))....................... Cryo-EM Structure of the Post-catalytic Spliceosome from Saccharomyces cerevisiae at 3.6 angstrom; U5 snRNA 5ylz D 103 3.6 RF00026 URS00006184A9_559292 29153833 0030621 0000244,0000353 0005688,0046540 559292 guucgcgaaguaacccuucguggacauuuggucaauuugaaacaauacagagaugaucagcaguuccccugcauaaggaugaaccguuuuacaaagagauuua <<<<<<<<<<.....>>>>>>>>>>.....................................<<<..<<<.....>>>...>>>................... ((((.(((((.....))))).)))).....................................(((.((((.....)))..))))................... Cryo-EM Structure of the Post-catalytic Spliceosome from Saccharomyces cerevisiae at 3.6 angstrom; U6 snRNA 5ylz E 62 3.6 29153833 559292 auaaauuuuuaagguauguauuuauuuuuuuuaagaacuagauacuaacacaaauaguaaau .............................................................. .............................................................. Cryo-EM Structure of the Post-catalytic Spliceosome from Saccharomyces cerevisiae at 3.6 angstrom; mRNA/intron lariat 5ylz F 91 3.6 RF00004 URS000023C730_559292 29153833 0045131 0000348 0005686 559292 acgaaucucuuugccuuuuggcuuagaucaaguguaguaucuguucuuuucaacauuuuuuggcaccgcgacccucgcacuuguggagucg ..................................................................<<...<<...........>>...>> ..................................................................((...(.............)...)) Cryo-EM Structure of the Post-catalytic Spliceosome from Saccharomyces cerevisiae at 3.6 angstrom; U2 snRNA 5yzg B 84 4.1 RF00020 URS000075BAAE_9606 29301961 0000244,0000353 0005682,0046540 9606 gguuucucuucagaucgcauaaaucuuucgccuuuuacuaaagauuuccguggagaggaacaacccaauuuuuugaggccuugc .<<<<<<<<<<<........<<<<<<<<...........>>>>>>>>...>>>>>>>>>>>....................... .(((.(((((((....(...((((((((.(.......).)))))))).).))))))).)))....................... The Cryo-EM Structure of Human Catalytic Step I Spliceosome (C complex) at 4.1 angstrom resolution; U5 snRNA 5yzg F 97 4.1 RF00026 URS00001EC8D7_9606 29301961 0030621 0000244,0000353 0005688,0046540 9606 gugcucgcuucggcagcacauauacuaaaauuggaacgauacagagaagauuagcauggccccugcgcaaggaugacacgcaaauucgugaagcguu <<<<<.<<<..>>>>>>>>.....................................<<...<<<.....>>>....>>................... (((((.((....))))))).....................................((..((((.....)))..).))................... The Cryo-EM Structure of Human Catalytic Step I Spliceosome (C complex) at 4.1 angstrom resolution; U6 snRNA 5yzg G 88 4.1 29301961 9606 ggaaacggccuccgaacgguaagagccuagcauguagaacugguuaccuccaggguuuccuugaugaugucauacuuauccugucccu ........................................................................................ ........................................................................................ The Cryo-EM Structure of Human Catalytic Step I Spliceosome (C complex) at 4.1 angstrom resolution; Pre-mRNA 5yzg H 139 4.1 RF00004 URS00003EE995_9606 29301961 0045131 0000348 0005686 9606 aucgcuucucggccuuuuggcuaagaucaaguguaguaucuguucuuuuaauauguccucuaccgaggacaauauuaaggauuuuuggagcagggagccacgcaucgaccugguauugcaguaccuccaggaacggugc ...............................................<<<<<<<<<<<<<....>>>>>>.>>>>>>>...............<......><<<<<<.<<<<<.............>>>>>..>>>>>> ...............................................(((((((((((((....)))))).)))))))...............(..()..)(((.((.(((((.............)))))..)).))) The Cryo-EM Structure of Human Catalytic Step I Spliceosome (C complex) at 4.1 angstrom resolution; U2 snRNA 5z1h A 19 2.4 URS000080DDE4_32630 29766661 32630 gcgucacgccggcggucgc ................... ................... Crystal structure of the bacterial ribosomal decoding site in complex with 6'-fluoro sisomicin; RNA (5'-R(*UP*UP*GP*CP*GP*UP*CP*AP*CP*GP*CP*CP*GP*GP*CP*GP*AP*AP*GP*UP*CP*GP*C)-3') 5z1h B 23 2.4 URS000080DDE4_32630 29766661 32630 uugcgucacgccggcgaagucgc ....................... ....................... Crystal structure of the bacterial ribosomal decoding site in complex with 6'-fluoro sisomicin; RNA (5'-R(*UP*UP*GP*CP*GP*UP*CP*AP*CP*GP*CP*CP*GP*GP*CP*GP*AP*AP*GP*UP*CP*GP*C)-3') 5z1i A 21 1.903 URS0000D56C51_32630 29766661 32630 gcgucgcgccggcgaagucgc ..................... ..................... Crystal structure of the protozoal cytoplasmic ribosomal decoding site in complex with 6'-fluoro sisomicin; RNA (5'-R(P*GP*CP*GP*UP*CP*GP*CP*GP*CP*CP*GP*GP*CP*GP*AP*AP*GP*UP*CP*GP*C)-3') 5z3g A 1501 3.65 RF02540,RF02543 URS000061F377_4932 29557065 0003735 0005840 4932 guuugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaaguggguggccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaugguguuuugugcccucugcuccuuguggguaggggacgcauuucacugggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaagguuggggccucgcaagaggugcacaaucgaccgauccggauuugaguaagagcauagcuguugggacccgaaagauggugaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugguaaggaaugaagagcuuuuagugggccauuuuuggagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucacaaaagguguuaguucaucugaacuagcccugggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcuagaucuagcgaaaccacagccaaggcuuggguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugaugcuccacacaaagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucagcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcgcugagauuaagccuuuguugucugauuug ..........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..<<<..<........<<.<<<<<<...>>>>>>.>>........>....<<<<<<.<<<<<<<<<<<<<<<<<<<<<.....<<<<......>>>>.(.......<<<......)>>>....>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....<<<<<..>>>>>..>>>..................................<<....>>...............<<<......>>>..................................<<<<<.<<<<<<.....<<<<...<<<..<<<<<<<<.......>>>>>>>>..>>>...>>>>..<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<.....<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>....<<<<<..<<<<<....>>>>>...>>>>>.<<....<..>......>>....>>>>>>.>>>>>...<<.<...<<<<<<.>>>>>>......>.>>..<<<<<<......<<<....>>>..<<<<<<<<.....<<<.<<<<<<.>>>>..>>>>>...>>>>>>.>>..<<<<.<<<....>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.......<<<.<<<<<<<<<..>>>>>>>>>>>>.)))......>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><<<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>.>>.....>>>>>><<.....<<<<<..>>>>>....>>....<<<<<.>>>>>.<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<......>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>..<<<<<<........<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>................>>>>>>.<<<<<<.<..<.......>..>.....<<<<<.<<<.<<.....<..>....>>....>>>..>>>>>..>>>>>> ..........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((.(((.(((((.((.((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..)))).)).....)))))))).))...)....(.(((((........))))).)......((((()))))...)))..................................((....))............(..((((....))))............).....................(((((.((((((.....((((...((.(.(((((.((.(....))).))))).).))...))))..(((((((((((((((((((((((.......(((((((......((((.((..)).)))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).)))))..((((........))))((((((..(.(((((..((((((..(((...(((.......)))...)))....(((((...((((....))))....))))).(((.(.(())..).).))....))))))..)))))..((.(...((((((.))))))......).))).((((((....(.(((....))).).(..(........(((.(((((...)))..)))))......)...)...((((.((......)).))))....(((......)))...(((((((...((([[[...(.(((((.........((.(((((((((..)))))))))))..]]].......)))))))))...)))))))((((((((...........))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....(((((())))))....))....(((((.))))).((.((((..((((.(.(((((......(....).....))))).)(((((...((((....(((((((.((....)).))..)))))...))))..))))).((((...((.(.............).))...)))).))))....)))).))..((((((.(......((.(........(((((((..).)))))).....))).......((((((...(((.(.(..(((......)))..).).))).))))))..............).))))))..(((((.(..(.......)..)...(.(((((.(((.((.....(())....).)...)))..)))))).))))). Cryo-EM structure of a nucleolar pre-60S ribosome (Rpf1-TAP); 25S rRNA 5z3g B 156 3.65 RF00002 URS00001BF64E_4932 29557065 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucau .........................................<<<<<<.<<.....>>>.....(.<<<(.....>>............).>>>..)...>>>....<<<...>>><<<<<<<<<....>>>>>>>>>................... ..........................................(((((.[[.....)))....((.((((.....]]............).)))..).).)).....((.....))(((((((((....)))))))))................... Cryo-EM structure of a nucleolar pre-60S ribosome (Rpf1-TAP); 5.8S rRNA 5z3g C 65 3.65 URS000013305B_4932 29557065 4932 ccuucucaaacauucuguuugguagugagugauacucuuuggaguuaacuugaaauugccuuaaa ......<<<<<.....>>>>>.....<<<<...<<<......>>>..>>>>.............. ......(((((.....)))))....(.(((...((........))..)))...)........... Cryo-EM structure of a nucleolar pre-60S ribosome (Rpf1-TAP); ITS2 RNA 5z56 B 84 5.1 RF00020 URS000075BAAE_9606 29360106 0000244,0000353 0005682,0046540 9606 gguuucucuucagaucgcauaaaucuuucgccuuuuacuaaagauuuccguggagaggaacaacccaauuuuuugaggccuugc .<<<<<<<<<<<........<<<<<<<<...........>>>>>>>>...>>>>>>>>>>>....................... .(((.(((((((....(...((((((((.(.......).)))))))).).))))))).)))....................... cryo-EM structure of a human activated spliceosome (mature Bact) at 5.1 angstrom.; U5 snRNA 5z56 F 93 5.1 RF00026 URS00001EC8D7_9606 29360106 0030621 0000244,0000353 0005688,0046540 9606 gugcucgcuucggcagcacauauacuaaaauuggaacgauacagagaagauuagcauggccccugcgcaaggaugacacauucgugaagcguu <<<<<.<<<..>>>>>>>>.....................................<<...<<<.....>>>....>>............... (((((.((....))))))).....................................((..((((.....)))..).))............... cryo-EM structure of a human activated spliceosome (mature Bact) at 5.1 angstrom.; U6 snRNA 5z56 G 77 5.1 29360106 10535 ggccuccgaacgguaagagccuagcauguagaacugguuaccuaugaugucauacuuauccugucccuuuuuuuucc ............................................................................. ............................................................................. cryo-EM structure of a human activated spliceosome (mature Bact) at 5.1 angstrom.; pre-mRNA 5z56 H 136 5.1 RF00004 URS00003EE995_9606 29360106 0045131 0000348 0005686 9606 aucgcuucucggccggcuaagaucaaguguaguaucuguucuuaucaguuuaauaucugauguccucucgaggacggauuuuuggagcagggagccacgcaucgaccugguauugcaguaccuccaggaacggugc ...........................................<<<<<........>>>>>.<<<<<..>>>>>................<......><<<<<<.<<<<<.............>>>>>..>>>>>> ...........................................(((((........)))))((((((..))))))...............(..()..)(((.((.(((((.............)))))..)).))) cryo-EM structure of a human activated spliceosome (mature Bact) at 5.1 angstrom.; U2 snRNA 5z57 B 84 6.5 RF00020 URS000075BAAE_9606 29360106 0000244,0000353 0005682,0046540 9606 gguuucucuucagaucgcauaaaucuuucgccuuuuacuaaagauuuccguggagaggaacaacccaauuuuuugaggccuugc .<<<<<<<<<<<........<<<<<<<<...........>>>>>>>>...>>>>>>>>>>>....................... .(((.(((((((....(...((((((((.(.......).)))))))).).))))))).)))....................... Cryo-EM structure of the human activated spliceosome (late Bact) at 6.5 angstrom; U5 snRNA 5z57 F 93 6.5 RF00026 URS00001EC8D7_9606 29360106 0030621 0000244,0000353 0005688,0046540 9606 gugcucgcuucggcagcacauauacuaaaauuggaacgauacagagaagauuagcauggccccugcgcaaggaugacacauucgugaagcguu <<<<<.<<<..>>>>>>>>.....................................<<...<<<.....>>>....>>............... (((((.((....))))))).....................................((..((((.....)))..).))............... Cryo-EM structure of the human activated spliceosome (late Bact) at 6.5 angstrom; U6 snRNA 5z57 G 77 6.5 29360106 10535 ggccuccgaacgguaagagccuagcauguagaacugguuaccuaugaugucauacuuauccugucccuuuuuuuucc ............................................................................. ............................................................................. Cryo-EM structure of the human activated spliceosome (late Bact) at 6.5 angstrom; pre-mRNA 5z57 H 136 6.5 RF00004 URS00003EE995_9606 29360106 0045131 0000348 0005686 9606 aucgcuucucggccggcuaagaucaaguguaguaucuguucuuaucaguuuaauaucugauguccucucgaggacggauuuuuggagcagggagccacgcaucgaccugguauugcaguaccuccaggaacggugc ...........................................<<<<<........>>>>>.<<<<<..>>>>>................<......><<<<<<.<<<<<.............>>>>>..>>>>>> ...........................................(((((........)))))((((((..))))))...............(..()..)(((.((.(((((.............)))))..)).))) Cryo-EM structure of the human activated spliceosome (late Bact) at 6.5 angstrom; U2 snRNA 5z58 B 84 4.9 RF00020 URS000075BAAE_9606 29360106 0000244,0000353 0005682,0046540 9606 gguuucucuucagaucgcauaaaucuuucgccuuuuacuaaagauuuccguggagaggaacaacccaauuuuuugaggccuugc .<<<<<<<<<<<........<<<<<<<<...........>>>>>>>>...>>>>>>>>>>>....................... .(((.(((((((....(...((((((((.(.......).)))))))).).))))))).)))....................... Cryo-EM structure of a human activated spliceosome (early Bact) at 4.9 angstrom.; U5 snRNA 5z58 F 93 4.9 RF00026 URS00001EC8D7_9606 29360106 0030621 0000244,0000353 0005688,0046540 9606 gugcucgcuucggcagcacauauacuaaaauuggaacgauacagagaagauuagcauggccccugcgcaaggaugacacauucgugaagcguu <<<<<.<<<..>>>>>>>>.....................................<<...<<<.....>>>....>>............... (((((.((....))))))).....................................((..((((.....)))..).))............... Cryo-EM structure of a human activated spliceosome (early Bact) at 4.9 angstrom.; U6 snRNA 5z58 G 77 4.9 29360106 10535 ggccuccgaacgguaagagccuagcauguagaacugguuaccuaugaugucauacuuauccugucccuuuuuuuucc ............................................................................. ............................................................................. Cryo-EM structure of a human activated spliceosome (early Bact) at 4.9 angstrom.; pre-mRNA 5z58 H 136 4.9 RF00004 URS00003EE995_9606 29360106 0045131 0000348 0005686 9606 aucgcuucucggccggcuaagaucaaguguaguaucuguucuuaucaguuuaauaucugauguccucucgaggacggauuuuuggagcagggagccacgcaucgaccugguauugcaguaccuccaggaacggugc ...........................................<<<<<........>>>>>.<<<<<..>>>>>................<......><<<<<<.<<<<<.............>>>>>..>>>>>> ...........................................(((((........)))))((((((..))))))...............(..()..)(((.((.(((((.............)))))..)).))) Cryo-EM structure of a human activated spliceosome (early Bact) at 4.9 angstrom.; U2 snRNA 5z71 A 19 2.5 URS0000D77917_32630 32630 ugcgucgcuccggagucgc ................... ................... Crystal structure of the Homo Sapiens cytoplasmic ribosomal decoding site in complex with G418 (P21212 form); RNA (5'-R(P*UP*GP*CP*GP*UP*CP*GP*CP*UP*CP*CP*GP*GP*AP*AP*AP*AP*GP*UP*CP*GP*C)-3') 5z71 B 22 2.5 URS0000D77917_32630 32630 ugcgucgcuccggaaaagucgc ...................... ...................... Crystal structure of the Homo Sapiens cytoplasmic ribosomal decoding site in complex with G418 (P21212 form); RNA (5'-R(P*UP*GP*CP*GP*UP*CP*GP*CP*UP*CP*CP*GP*GP*AP*AP*AP*AP*GP*UP*CP*GP*C)-3') 5z98 C 10 2.2 URS0000D77949_32644 30060196 32644 cugccgggua .......... .......... Crystal Structure of the Primate APOBEC3H Dimer mediated by RNA Duplex; RNA (5'-R(P*CP*UP*GP*CP*CP*GP*GP*GP*UP*A)-3') 5z98 D 10 2.2 URS0000D77946_32644 30060196 32644 auacccggca .......... .......... Crystal Structure of the Primate APOBEC3H Dimer mediated by RNA Duplex; RNA (5'-R(*AP*UP*AP*CP*CP*CP*GP*GP*CP*A)-3') 5zeb a 1506 3.4 RF00177,RF01959,RF01960 URS00001AF2F7_246196 30206241 0003735 0005840 246196 uggagaguuugauccuggcucaggacgaacgcuggcggcgugcuuaacacaugcaagucgaacggaaaggcccuuucggggguacucgaguggcgaacgggugaguaacacgugggugaucugcccugcacuuugggauaagccugggaaacugggucuaauaccgaauacacccugcuggucgcauggccugguaggggaaagcuuuugcggugugggaugggcccgcggccuaucagcuuguugguggggugauggccuaccaaggcgacgacggguagccggccugagagggugaccggccacacugggacugagauacggcccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagcgacgccgcgugagggaugacggccuucggguuguaaaccucuuucagcacagacgaagcgcaagugacgguaugugcagaagaaggaccggccaacuacgugccagcagccgcgguaauacguaggguccgagcguuguccggaauuacugggcguaaagagcucguaggugguuugucgcguuguucgugaaaacucacagcuuaacugugggcgugcgggcgauacgggcagacuagaguacugcaggggagacuggaauuccugguguagcgguggaaugcgcagauaucaggaggaacaccgguggcgaaggcgggucucugggcaguaacugacgcugaggagcgaaagcguggggagcgaacaggauuagauacccugguaguccacgccguaaacgguggguacuagguguggguuuccuugggauccgugccguagcuaacgcauuaaguaccccgccuggggaguacggccgcaaggcuaaaacucaaaggaauugacgggggcccgcacaagcggcggagcauguggauuaauucgaugcaacgcgaagaaccuuaccuggguuugacaugcacaggacgccggcagagaugucgguucccuuguggccugugugcagguggugcauggcugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuugucucauguugccagcacguuaugguggggacucgugagagacugccggggucaacucggaggaagguggggaugacgucaagucaucaugccccuuauguccagggcuucacacaugcuacaauggccgguacaaagggcugcgaugccgugagguggagcgaauccuuucaaagccggucucaguucggaucggggucugcaacucgaccccgugaagucggagucgcuaguaaucgcagaucagcaacgcugcggugaauacguucccgggccuuguacacaccgcccgucacgucaugaaagucgguaacacccgaagccgguggccuaacccuuguggagggagccgucgaaggugggaucggcgauugggacgaagucguaacaagguagccguaccggaaggugcggcuggauca ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<..<<<<<<<....>>>>>.>>>..>>>>>......<<........<<<<<<<..<<...<<<<<<<<<<<<.....<<<<<......>>>>>......>>>>.....<<<<<<<<<<<<..>>>>>.>>>>>>>....<<....>>>>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<<....>>.......>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<.....<<<<<<<.....>>>>>>>...>>>>>>>..>>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<<..<<<......>>>.....>>>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<...>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>.<<.....>>.>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<<..<<<......>>>>>.....>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>......>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<..<<<<....<.<<<<..<<<..<<.....>>.>>>.>>>>.>...>>>>..>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((....))))).)))..)))))......(((.......(((((((..((...(((((((.((((.....((((((....))))))......)))).....(((((((((((....)))).)))))))....((....)).)))))))..))))))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(..((....))..)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((.....(((((((.....)))))))...))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((.(...).))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((...(((((((....))))))).((.....))).))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((.(...((..(((......)))))....).)))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((..((...(((....)))...))....)))......)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((..((((....(.((((..(((..(((..).)).))).)))).)...))))..))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... M. Smegmatis P/P state 70S ribosome structure; 16S rRNA 5zeb v 77 3.4 RF00005 URS00001BBAFC_562 30206241 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaagaucgucgguucaaauccggcccccgcaacca .<<<<<...<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>.>>>>>..... .(((((...((((......[..)))).(((((.......))))).....(((((..]....))))).)))))..... M. Smegmatis P/P state 70S ribosome structure; P-tRNAfMet 5zeb B 117 3.4 RF00001 URS000047BBB1_246196 30206241 0003735 0005840 246196 guuacggcgguccauagcggcagggaaacgcccggucccaucccgaacccggaagcuaagccugccagcgccgaugauacuacccuuccggguggaaaaguaggacaccgccgaaca <<<..<..<..........<........<.<...................>...>.......>.................<.<......>.>...............>..>..>>>. (((..(..(.........(.........(.(..(.............)..)...).........).................(......).................)..)..))). M. Smegmatis P/P state 70S ribosome structure; 5S rRNA 5zeb A 3102 3.4 RF02540,RF02541 URS0000BC467B_246196 30206241 0003735 0005840 246196 aaguguuuaagggcgcaugguggaugccuuggcacugggagccgaugaaggacguaggaggcugcgauaagccucggggagcugucaaccgagcguugauccgaggauguccgaauggggaaacccggcacgagugaugucgugucaccaggcgcugaauauauaggcgucuggggggaacgcggggaagugaaacaucucaguacccguaggaagagaaaacaaaaugugauuccgugaguaguggcgagcgaaagcggaggauggcuaaaccguaugcaugugauaccggguagggguugugugugcgggguugugggaccuaucuuuccggcucugcuggagggcagugagaaaauguugugguuagcggaaauggcuugggauggccugccguagacggugagagcccgguacgugaaaacccgacgucugucuugaugguguucccgaguagcagcgggcccguggaaucugcugugaaucugccgggaccacccgguaagccugaauacuucccagugaccgauagcggauuaguaccgugagggaauggugaaaaguaccccgggaggggagugaaagaguaccugaaaccgugcgcuuacaauccgucagagcccucgaucguggggugauggcgugccuuuugaagaaugagccugcgagucagggacaugucgcgagguuaacccgggugggguagccgcagcgaaagcgagucugaauagggcguauccacacaagagugugugguguagugguguguucuggacccgaagcggagugaucuacccauggccagggugaagcgcggguaagaccgcguggaggcccgaacccacuuagguugaagacugaggggaugagcuguggguaggggugaaaggccaaucaaacuccgugauagcugguucuccccgaaaugcauuuaggugcagcgucgcauguuucuugccggagguagagcuacuggauggccgaugggccccaggguuacugacgucagccaaacuccgaaugccgguaaguccaagagugcggcagugagacggcgggggauaagcuccgugcgucgagagggaaacagcccagaucgccggcuaaggccccuaagcgugugcuaaguggaaaaggaugugcagucgcgaagacaaccaggagguuggcuuagaagcagccacccuugaaagagugcguaauagcucacuggucaagugauugugcgccgauaauguagcggggcucaagcacaccgccgaagccgcggcagccaacguguuggcuggguaggggagcguccugcauccggugaagccgccgagugaucgagugguggagggugugggagugagaaugcaggcaugaguagcgauuaggcaagugagaaccuugcccgccgaaagaccaaggguuccugggccaggccaguccgcccagggugagucgggaccuaaggcgaggccgacaggcguagucgauggacaacggguugauauucccguacccguguaugugcguccaugaugaaucagcgguacuaaccauccaaaaccaccgugaccgcaccuuucgggguguggcguugguggggcugcaugggaccuucguugguaguagucaagcgauggggugacgcaggaagguagccguaccggucagugguaauaccgggguaagccuguagggagucagauagguaaauccgucuggcauauauccugagaggugaugcauagccgagaggcgaauucggugauccuaugcugccgagaaaagccucuagcgaggacauacacggcccguaccccaaaccaacacagguggucagguagagaauacuaaggcguacgagugaacuaugguuaaggaacucggcaaaaugcccccguaacuucgggagaagggggacccacauggcguguaagccucggcccaagcgugaguggguggcacaaaccagugagaagcgacuguuuacuaaaaacacagguccgugcgaagucgcaagacgauguauacggacugacgccugcccggugcuggaagguuaagaggacccguuaacucccuuugggggugaagcggagaauuuaagccccaguaaacggcggugguaacuauaaccauccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaacgacuucucaacugucucaaccauagacucggcgaaauugcacuacgaguaaagaugcucguuacgcgcggcaggacgaaaagaccccgggaccuucacuacaacuugguauuggugcucgauacgguuuguguaggauaggugggagacugugaagcucacacgccaguguggguggagucguuguugaaauaccacucugaucguauugggccucuaaccucggaccguauauccgguucagggacagugccugguggguaguuuaacuggggcgguugccuccuaaaauguaacggaggcgcccaaagguucccucaaccuggacggcaaucagguguugaguguaagugcacaagggagcuugacugcgagacggacaugucgagcagggacgaaagucgggacuagugauccggcaccucugaguggaaggggugucgcucaacggauaaaagguaccccggggauaacaggcugaucuuccccaagaguccauaucgacgggaugguuuggcaccucgaugucggcucgucgcauccuggggcuggagcaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguuuagaacgucgugagacaguucggucucuauccgccgcgcgcgucagaagcuugaggaaaccugucccuaguacgagaggaccgggacggacgaaccucugguauaccaguugucccaccaggggcacggcuggauagccacguucggacaggauaaccgcugaaagcaucuaagcgggaaaccucuuccaagaccaggcuucucacccucuaggagggauaaggccccccgcagaccacgggauugauagaccagaccuggaagccuaguaauaggugcagggaacuggcacuaaccggccgaaaacuua <<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<<......<<<<<<.[[.(((.>>>.....<<<<<<<..<<<)))..]].>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<.....>>..<<<<<<.....<<.....>>....>>>>>>...<<<....<<<<<<<<<<............<<.....>>>>>>>>>>......<<<<..[.....<<<<<<.>>>>>>>><<<<<<.......<<<<<<.<<<<.<<<.....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>>>.....]...>>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..>>>......>>.>>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<<..>>.>>>>>..>>>>...<.<........>.>.<<<<<<....<<<.<<<<<<<<<<..<<<...<<<....>>>...>>>...<<....>>..<<<<.....>>>>....<<<<<<<....>>>>>>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<....<<<<<<<<.....<<<....<<<.<<<<....<<<<<<..>>>>>.>....>>>>.>>>..>>.>.....>>>>>>>>.......>>>>>>>.>>..<<<<<<<<<<......>>>>>>.>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>...........)))......>>>>>>.>>>...>>>>>>><<<<<<<<..>>>>>>>>....>>>>>><.<<<<<<<<<<......<<<<<<<<....>>>.>>>>>...>>>>>>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<.......<<<<..<<<<<<<<......<<<<.<<.............<...<.<....>.>...>.............>>.>>>>.....>>>>>>>>....>>>>.<<...<<<<<...<<<<..<<<..<<<<..<<<<<...((((...>>>>>.<<..<<<<...<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>...>>>>...>><<.<<<....>>>..>>.>>>>...>>>...>>>>........>>>>>..>>....>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<<...<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<...<<<<....<<<..>>>....>>>>..>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.<<<....<<<<<.<<<<<<...>>>>>>..>>>>>....>>>.>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>>>>>>>>.....>.((..<<<<<......))>>>>>..<<<<<<<<.<<<.<<......<<<<<<<<<<..<<<<<.<<<.<<<<<.<<.<<<<<<<<<<<<<.............<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>....>>>>>>>>>>>>>.>>...<<<.<<<<<<......>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.<<..>>>>..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<.<<<<...<<.......>>...>>>>.>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))))>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<...>>>>>....<<<<.<<<<.......>>>>.....<<<.<<<<.<<<....<<<<<....>>>>>...>>>..>>>>..>>>...>>>>....>>>>. ((((......((((((((((.....(((..(((((((((((((......((((((.[[.[[[.))).....((((((...(((]]]..]].)))......))))))...)))....(((....)))(((((((......))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))....((([...(((((.(((.............[[......))).)))))....(.((((.(....(.((((((.]])))))).(((((.......((((((.((((.(((...(.((((......)))))[[(...).(((.....]])))...)))...)))))))))))))))..).....).))))]....(((((((...[.......)))))))....).(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((..(((((((())).)))))..)))).<.(.(........).).((((((..(.(((.((((((((((..(((...(((....)))...)))...((....))..((((.....))))....(((((((....)))))))....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......A))))))))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))(((((((((.([.((((((((.....(((....(((.((((....(.((((..))))..)....)))).)))..)).).....))))))))....).]))))))).))..((((((((((......)))))).))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.((([.(((.........)))..))).....(]..((......)).).)))))...)))))))))).))...........]]].)....))))))))))...)))))))((((((((..))))))))....))))))(.((((((((((......((((((((....))).)))))...))))))))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]]((((((((((.(.....(((...(.(((((.......((((..(.......(..........(......)...........)......)..))))......))))).).....))).((...(((((...((((..(((..((((..(((((....{{{...))))).((..(((....(((((.(((((.((.....))))))).).....))))..[.)))...))(..(((....)))...).))))...)))...))))(..)....)))))..))..).)))))))))))))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((...((((....(((.])))....))))..))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((....(....((((..((.(((...))).))...))))....)....))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....))[[..(((((.....>]])))))..((((((((.(((.((......((((((((((..(((((.(((.(((((.((.((((((((((.(..(..........((((...((......((((((((....))))))))...)).............)))).)..).)))))))))).))...(((.((((((......)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.(.((((...((.......))...)))).)...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))..a.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..(((((...)))))....((((.((((.......)))).....(((.((((.(((....(((((....)))))...)))..))))..)))...))))....)))). M. Smegmatis P/P state 70S ribosome structure; 23S rRNA 5zeg A 23 2.4 URS000086854A_32630 29036479 32630 uugcgucncgucgacgaagucgc ....................... ....................... Crystal structure of the bacterial A1408me1A-mutant ribosomal decoding site; RNA (5'-R(*UP*UP*GP*CP*GP*UP*CP*(1MA)P*CP*GP*UP*CP*GP*AP*CP*GP*AP*AP*GP*UP*CP*GP*C)-3') 5zeg B 23 2.4 URS000086854A_32630 29036479 32630 uugcgucncgucgacgaagucgc ....................... ....................... Crystal structure of the bacterial A1408me1A-mutant ribosomal decoding site; RNA (5'-R(*UP*UP*GP*CP*GP*UP*CP*(1MA)P*CP*GP*UP*CP*GP*AP*CP*GP*AP*AP*GP*UP*CP*GP*C)-3') 5zeg C 23 2.4 URS000086854A_32630 29036479 32630 uugcgucncgucgacgaagucgc ....................... ....................... Crystal structure of the bacterial A1408me1A-mutant ribosomal decoding site; RNA (5'-R(*UP*UP*GP*CP*GP*UP*CP*(1MA)P*CP*GP*UP*CP*GP*AP*CP*GP*AP*AP*GP*UP*CP*GP*C)-3') 5zei A 22 2.1 URS0000D56C3E_32630 29036479 32630 ugcgucncgucgacgaagucgc ...................... ...................... Crystal structure of the bacterial A1408me1A-mutant ribosomal decoding site in complex with geneticin; RNA (5'-R(P*UP*GP*CP*GP*UP*CP*(1MA)P*CP*GP*UP*CP*GP*AP*CP*GP*AP*AP*GP*UP*CP*GP*C)-3') 5zei B 21 2.1 URS0000D56C39_32630 29036479 32630 gcgucncgucgacgaagucgc ..................... ..................... Crystal structure of the bacterial A1408me1A-mutant ribosomal decoding site in complex with geneticin; RNA (5'-R(P*GP*CP*GP*UP*CP*(1MA)P*CP*GP*UP*CP*GP*AP*CP*GP*AP*AP*GP*UP*CP*GP*C)-3') 5zej A 22 3.5 URS0000D56C3E_32630 29036479 32630 ugcgucncgucgacgaagucgc ...................... ...................... Crystal structure of the bacterial A1408me1A-mutant ribosomal decoding site in complex with paromomycin; RNA (5'-R(P*UP*GP*CP*GP*UP*CP*(1MA)P*CP*GP*UP*CP*GP*AP*CP*GP*AP*AP*GP*UP*CP*GP*C)-3') 5zej B 22 3.5 URS0000D56C3E_32630 29036479 32630 ugcgucncgucgacgaagucgc ...................... ...................... Crystal structure of the bacterial A1408me1A-mutant ribosomal decoding site in complex with paromomycin; RNA (5'-R(P*UP*GP*CP*GP*UP*CP*(1MA)P*CP*GP*UP*CP*GP*AP*CP*GP*AP*AP*GP*UP*CP*GP*C)-3') 5zem A 22 3.103 URS0000D56C3E_32630 29036479 32630 ugcgucncgucgacgaagucgc ...................... ...................... Crystal structure of the bacterial A1408me1A-mutant ribosomal decoding site in the presence of gentamicin; RNA (5'-R(P*UP*GP*CP*GP*UP*CP*(1MA)P*CP*GP*UP*CP*GP*AP*CP*GP*AP*AP*GP*UP*CP*GP*C)-3') 5zem B 21 3.103 URS0000D56C3E_32630 29036479 32630 gcgucncgucgacgaagucgc ..................... ..................... Crystal structure of the bacterial A1408me1A-mutant ribosomal decoding site in the presence of gentamicin; RNA (5'-R(P*UP*GP*CP*GP*UP*CP*(1MA)P*CP*GP*UP*CP*GP*AP*CP*GP*AP*AP*GP*UP*CP*GP*C)-3') 5zep a 1506 3.4 RF00177,RF01959,RF01960 URS00001AF2F7_246196 30206241 0003735 0005840 246196 uggagaguuugauccuggcucaggacgaacgcuggcggcgugcuuaacacaugcaagucgaacggaaaggcccuuucggggguacucgaguggcgaacgggugaguaacacgugggugaucugcccugcacuuugggauaagccugggaaacugggucuaauaccgaauacacccugcuggucgcauggccugguaggggaaagcuuuugcggugugggaugggcccgcggccuaucagcuuguugguggggugauggccuaccaaggcgacgacggguagccggccugagagggugaccggccacacugggacugagauacggcccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagcgacgccgcgugagggaugacggccuucggguuguaaaccucuuucagcacagacgaagcgcaagugacgguaugugcagaagaaggaccggccaacuacgugccagcagccgcgguaauacguaggguccgagcguuguccggaauuacugggcguaaagagcucguaggugguuugucgcguuguucgugaaaacucacagcuuaacugugggcgugcgggcgauacgggcagacuagaguacugcaggggagacuggaauuccugguguagcgguggaaugcgcagauaucaggaggaacaccgguggcgaaggcgggucucugggcaguaacugacgcugaggagcgaaagcguggggagcgaacaggauuagauacccugguaguccacgccguaaacgguggguacuagguguggguuuccuugggauccgugccguagcuaacgcauuaaguaccccgccuggggaguacggccgcaaggcuaaaacucaaaggaauugacgggggcccgcacaagcggcggagcauguggauuaauucgaugcaacgcgaagaaccuuaccuggguuugacaugcacaggacgccggcagagaugucgguucccuuguggccugugugcagguggugcauggcugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuugucucauguugccagcacguuaugguggggacucgugagagacugccggggucaacucggaggaagguggggaugacgucaagucaucaugccccuuauguccagggcuucacacaugcuacaauggccgguacaaagggcugcgaugccgugagguggagcgaauccuuucaaagccggucucaguucggaucggggucugcaacucgaccccgugaagucggagucgcuaguaaucgcagaucagcaacgcugcggugaauacguucccgggccuuguacacaccgcccgucacgucaugaaagucgguaacacccgaagccgguggccuaacccuuguggagggagccgucgaaggugggaucggcgauugggacgaagucguaacaagguagccguaccggaaggugcggcuggauca ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<..<<<<<<<....>>>>>.>>>..>>>>>......<<........<<<<<<<..<<...<<<<<<<<<<<<.....<<<<<......>>>>>......>>>>.....<<<<<<<<<<<<..>>>>>.>>>>>>>....<<....>>>>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<<....>>.......>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<.....<<<<<<<.....>>>>>>>...>>>>>>>..>>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<<..<<<......>>>.....>>>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<...>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>.<<.....>>.>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<<..<<<......>>>>>.....>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>......>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<..<<<<....<.<<<<..<<<..<<.....>>.>>>.>>>>.>...>>>>..>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((....))))).)))..)))))......(((.......(((((((..((...(((((((.((((.....((((((....))))))......)))).....(((((((((((....)))).)))))))....((....)).)))))))..))))))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(..((....))..)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((.....(((((((.....)))))))...))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((.(...).))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((...(((((((....))))))).((.....))).))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((.(...((..(((......)))))....).)))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((..((...(((....)))...))....)))......)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((..((((....(.((((..(((..(((..).)).))).)))).)...))))..))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... M. smegmatis hibernating state 70S ribosome structure; 16S rRNA 5zep w 77 3.4 RF00005 URS00001BBAFC_562 30206241 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaagaucgucgguucaaauccggcccccgcaacca .<<<<<...<<<<.........>>>>..<<<<.......>>>>......<<<<<.......>>>>>.>>>>>..... ...((((..((.(.........).))..((((.......))))......(.(((.......))).)))))....... M. smegmatis hibernating state 70S ribosome structure; E-tRNAfMet 5zep B 117 3.4 RF00001 URS000047BBB1_246196 30206241 0003735 0005840 246196 guuacggcgguccauagcggcagggaaacgcccggucccaucccgaacccggaagcuaagccugccagcgccgaugauacuacccuuccggguggaaaaguaggacaccgccgaaca <<<..<..<..........<........<.<...................>...>.......>.................<.<......>.>...............>..>..>>>. (((..(..(.........(.........(.(..(.............)..)...).........).................(......).................)..)..))). M. smegmatis hibernating state 70S ribosome structure; 5S rRNA 5zep A 3102 3.4 RF02540,RF02541 URS0000BC467B_246196 30206241 0003735 0005840 246196 aaguguuuaagggcgcaugguggaugccuuggcacugggagccgaugaaggacguaggaggcugcgauaagccucggggagcugucaaccgagcguugauccgaggauguccgaauggggaaacccggcacgagugaugucgugucaccaggcgcugaauauauaggcgucuggggggaacgcggggaagugaaacaucucaguacccguaggaagagaaaacaaaaugugauuccgugaguaguggcgagcgaaagcggaggauggcuaaaccguaugcaugugauaccggguagggguugugugugcgggguugugggaccuaucuuuccggcucugcuggagggcagugagaaaauguugugguuagcggaaauggcuugggauggccugccguagacggugagagcccgguacgugaaaacccgacgucugucuugaugguguucccgaguagcagcgggcccguggaaucugcugugaaucugccgggaccacccgguaagccugaauacuucccagugaccgauagcggauuaguaccgugagggaauggugaaaaguaccccgggaggggagugaaagaguaccugaaaccgugcgcuuacaauccgucagagcccucgaucguggggugauggcgugccuuuugaagaaugagccugcgagucagggacaugucgcgagguuaacccgggugggguagccgcagcgaaagcgagucugaauagggcguauccacacaagagugugugguguagugguguguucuggacccgaagcggagugaucuacccauggccagggugaagcgcggguaagaccgcguggaggcccgaacccacuuagguugaagacugaggggaugagcuguggguaggggugaaaggccaaucaaacuccgugauagcugguucuccccgaaaugcauuuaggugcagcgucgcauguuucuugccggagguagagcuacuggauggccgaugggccccaggguuacugacgucagccaaacuccgaaugccgguaaguccaagagugcggcagugagacggcgggggauaagcuccgugcgucgagagggaaacagcccagaucgccggcuaaggccccuaagcgugugcuaaguggaaaaggaugugcagucgcgaagacaaccaggagguuggcuuagaagcagccacccuugaaagagugcguaauagcucacuggucaagugauugugcgccgauaauguagcggggcucaagcacaccgccgaagccgcggcagccaacguguuggcuggguaggggagcguccugcauccggugaagccgccgagugaucgagugguggagggugugggagugagaaugcaggcaugaguagcgauuaggcaagugagaaccuugcccgccgaaagaccaaggguuccugggccaggccaguccgcccagggugagucgggaccuaaggcgaggccgacaggcguagucgauggacaacggguugauauucccguacccguguaugugcguccaugaugaaucagcgguacuaaccauccaaaaccaccgugaccgcaccuuucgggguguggcguugguggggcugcaugggaccuucguugguaguagucaagcgauggggugacgcaggaagguagccguaccggucagugguaauaccgggguaagccuguagggagucagauagguaaauccgucuggcauauauccugagaggugaugcauagccgagaggcgaauucggugauccuaugcugccgagaaaagccucuagcgaggacauacacggcccguaccccaaaccaacacagguggucagguagagaauacuaaggcguacgagugaacuaugguuaaggaacucggcaaaaugcccccguaacuucgggagaagggggacccacauggcguguaagccucggcccaagcgugaguggguggcacaaaccagugagaagcgacuguuuacuaaaaacacagguccgugcgaagucgcaagacgauguauacggacugacgccugcccggugcuggaagguuaagaggacccguuaacucccuuugggggugaagcggagaauuuaagccccaguaaacggcggugguaacuauaaccauccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaacgacuucucaacugucucaaccauagacucggcgaaauugcacuacgaguaaagaugcucguuacgcgcggcaggacgaaaagaccccgggaccuucacuacaacuugguauuggugcucgauacgguuuguguaggauaggugggagacugugaagcucacacgccaguguggguggagucguuguugaaauaccacucugaucguauugggccucuaaccucggaccguauauccgguucagggacagugccugguggguaguuuaacuggggcgguugccuccuaaaauguaacggaggcgcccaaagguucccucaaccuggacggcaaucagguguugaguguaagugcacaagggagcuugacugcgagacggacaugucgagcagggacgaaagucgggacuagugauccggcaccucugaguggaaggggugucgcucaacggauaaaagguaccccggggauaacaggcugaucuuccccaagaguccauaucgacgggaugguuuggcaccucgaugucggcucgucgcauccuggggcuggagcaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguuuagaacgucgugagacaguucggucucuauccgccgcgcgcgucagaagcuugaggaaaccugucccuaguacgagaggaccgggacggacgaaccucugguauaccaguugucccaccaggggcacggcuggauagccacguucggacaggauaaccgcugaaagcaucuaagcgggaaaccucuuccaagaccaggcuucucacccucuaggagggauaaggccccccgcagaccacgggauugauagaccagaccuggaagccuaguaauaggugcagggaacuggcacuaaccggccgaaaacuua <<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<<......<<<<<<.[[.(((.>>>.....<<<<<<<..<<<)))..]].>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<.....>>..<<<<<<.....<<.....>>....>>>>>>...<<<....<<<<<<<<<<............<<.....>>>>>>>>>>......<<<<..[.....<<<<<<.>>>>>>>><<<<<<.......<<<<<<.<<<<.<<<.....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>>>.....]...>>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..>>>......>>.>>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<<..>>.>>>>>..>>>>...<.<........>.>.<<<<<<....<<<.<<<<<<<<<<..<<<...<<<....>>>...>>>...<<....>>..<<<<.....>>>>....<<<<<<<....>>>>>>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<....<<<<<<<<.....<<<....<<<.<<<<....<<<<<<..>>>>>.>....>>>>.>>>..>>.>.....>>>>>>>>.......>>>>>>>.>>..<<<<<<<<<<......>>>>>>.>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>...........)))......>>>>>>.>>>...>>>>>>><<<<<<<<..>>>>>>>>....>>>>>><.<<<<<<<<<<......<<<<<<<<....>>>.>>>>>...>>>>>>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<.......<<<<..<<<<<<<<......<<<<.<<...<<<<<........<<<<....>>>>........>>>>>...>>.>>>>.....>>>>>>>>....>>>>.<<...<<<<<...<<<<..<<<..<<<<..<<<<<...((((...>>>>>.<<..<<<<...<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>...>>>>...>><<.<<<....>>>..>>.>>>>...>>>...>>>>........>>>>>..>>....>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<<...<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<...<<<<....<<<..>>>....>>>>..>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.<<<....<<<<<.<<<<<<...>>>>>>..>>>>>....>>>.>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>>>>>>>>.....>.((..<<<<<......))>>>>>..<<<<<<<<.<<<.<<......<<<<<<<<<<..<<<<<.<<<.<<<<<.<<.<<<<<<<<<<<<<.............<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>....>>>>>>>>>>>>>.>>...<<<.<<<<<<......>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.<<..>>>>..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<.<<<<...<<.......>>...>>>>.>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))))>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<...>>>>>....<<<<.<<<<.......>>>>.....<<<.<<<<.<<<....<<<<<....>>>>>...>>>..>>>>..>>>...>>>>....>>>>. ((((......((((((((((.....(((..(((((((((((((......((((((.[[.[[[.))).....((((((...(((]]]..]].)))......))))))...)))....(((....)))(((((((......))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))....((([...(((((.(((.............[[......))).)))))....(.((((.(....(.((((((.]])))))).(((((.......((((((.((((.(((...(.((((......)))))[[(...).(((.....]])))...)))...)))))))))))))))..).....).))))]....(((((((...[.......)))))))....).(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((..(((((((())).)))))..)))).<.(.(........).).((((((..(.(((.((((((((((..(((...(((....)))...)))...((....))..((((.....))))....(((((((....)))))))....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......A))))))))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))(((((((((.([.((((((((.....(((....(((.((((....(.((((..))))..)....)))).)))..)).).....))))))))....).]))))))).))..((((((((((......)))))).))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.((([.(((.........)))..))).....(]..((......)).).)))))...)))))))))).))...........]]].)....))))))))))...)))))))((((((((..))))))))....))))))(.((((((((((......((((((((....))).)))))...))))))))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]]((((((((((.(.....(((...(.(((((.......(((...(...(............(((......)))............)...)...)))......))))).).....))).((...(((((...((((..(((..((((..(((((....{{{...))))).((..(((....(((((.(((((.((.....))))))).).....))))..[.)))...))(..(((....)))...).))))...)))...))))(..)....)))))..))..).)))))))))))))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((...((((....(((.])))....))))..))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((....(....((((..((.(((...))).))...))))....)....))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....))[[..(((((.....>]])))))..((((((((.(((.((......((((((((((..(((((.(((.(((((.((.((((((((((.(..(..........((((...((......((((((((....))))))))...)).............)))).)..).)))))))))).))...(((.((((((......)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.(.((((...((.......))...)))).)...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))..a.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..(((((...)))))....((((.((((.......)))).....(((.((((.(((....(((((....)))))...)))..))))..)))...))))....)))). M. smegmatis hibernating state 70S ribosome structure; 23S rRNA 5zet B 117 3.2 RF00001 URS000047BBB1_246196 30206241 0003735 0005840 246196 guuacggcgguccauagcggcagggaaacgcccggucccaucccgaacccggaagcuaagccugccagcgccgaugauacuacccuuccggguggaaaaguaggacaccgccgaaca <<<..<..<..........<........<.<...................>...>.......>.................<.<......>.>...............>..>..>>>. (((..(..(.....................(..(.............)..)...............................(......).................)..)..))). M. smegmatis P/P state 50S ribosomal subunit; P-tRNAfMet 5zet A 3102 3.2 RF02540,RF02541 URS0000BC467B_246196 30206241 0003735 0005840 246196 aaguguuuaagggcgcaugguggaugccuuggcacugggagccgaugaaggacguaggaggcugcgauaagccucggggagcugucaaccgagcguugauccgaggauguccgaauggggaaacccggcacgagugaugucgugucaccaggcgcugaauauauaggcgucuggggggaacgcggggaagugaaacaucucaguacccguaggaagagaaaacaaaaugugauuccgugaguaguggcgagcgaaagcggaggauggcuaaaccguaugcaugugauaccggguagggguugugugugcgggguugugggaccuaucuuuccggcucugcuggagggcagugagaaaauguugugguuagcggaaauggcuugggauggccugccguagacggugagagcccgguacgugaaaacccgacgucugucuugaugguguucccgaguagcagcgggcccguggaaucugcugugaaucugccgggaccacccgguaagccugaauacuucccagugaccgauagcggauuaguaccgugagggaauggugaaaaguaccccgggaggggagugaaagaguaccugaaaccgugcgcuuacaauccgucagagcccucgaucguggggugauggcgugccuuuugaagaaugagccugcgagucagggacaugucgcgagguuaacccgggugggguagccgcagcgaaagcgagucugaauagggcguauccacacaagagugugugguguagugguguguucuggacccgaagcggagugaucuacccauggccagggugaagcgcggguaagaccgcguggaggcccgaacccacuuagguugaagacugaggggaugagcuguggguaggggugaaaggccaaucaaacuccgugauagcugguucuccccgaaaugcauuuaggugcagcgucgcauguuucuugccggagguagagcuacuggauggccgaugggccccaggguuacugacgucagccaaacuccgaaugccgguaaguccaagagugcggcagugagacggcgggggauaagcuccgugcgucgagagggaaacagcccagaucgccggcuaaggccccuaagcgugugcuaaguggaaaaggaugugcagucgcgaagacaaccaggagguuggcuuagaagcagccacccuugaaagagugcguaauagcucacuggucaagugauugugcgccgauaauguagcggggcucaagcacaccgccgaagccgcggcagccaacguguuggcuggguaggggagcguccugcauccggugaagccgccgagugaucgagugguggagggugugggagugagaaugcaggcaugaguagcgauuaggcaagugagaaccuugcccgccgaaagaccaaggguuccugggccaggccaguccgcccagggugagucgggaccuaaggcgaggccgacaggcguagucgauggacaacggguugauauucccguacccguguaugugcguccaugaugaaucagcgguacuaaccauccaaaaccaccgugaccgcaccuuucgggguguggcguugguggggcugcaugggaccuucguugguaguagucaagcgauggggugacgcaggaagguagccguaccggucagugguaauaccgggguaagccuguagggagucagauagguaaauccgucuggcauauauccugagaggugaugcauagccgagaggcgaauucggugauccuaugcugccgagaaaagccucuagcgaggacauacacggcccguaccccaaaccaacacagguggucagguagagaauacuaaggcguacgagugaacuaugguuaaggaacucggcaaaaugcccccguaacuucgggagaagggggacccacauggcguguaagccucggcccaagcgugaguggguggcacaaaccagugagaagcgacuguuuacuaaaaacacagguccgugcgaagucgcaagacgauguauacggacugacgccugcccggugcuggaagguuaagaggacccguuaacucccuuugggggugaagcggagaauuuaagccccaguaaacggcggugguaacuauaaccauccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaacgacuucucaacugucucaaccauagacucggcgaaauugcacuacgaguaaagaugcucguuacgcgcggcaggacgaaaagaccccgggaccuucacuacaacuugguauuggugcucgauacgguuuguguaggauaggugggagacugugaagcucacacgccaguguggguggagucguuguugaaauaccacucugaucguauugggccucuaaccucggaccguauauccgguucagggacagugccugguggguaguuuaacuggggcgguugccuccuaaaauguaacggaggcgcccaaagguucccucaaccuggacggcaaucagguguugaguguaagugcacaagggagcuugacugcgagacggacaugucgagcagggacgaaagucgggacuagugauccggcaccucugaguggaaggggugucgcucaacggauaaaagguaccccggggauaacaggcugaucuuccccaagaguccauaucgacgggaugguuuggcaccucgaugucggcucgucgcauccuggggcuggagcaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguuuagaacgucgugagacaguucggucucuauccgccgcgcgcgucagaagcuugaggaaaccugucccuaguacgagaggaccgggacggacgaaccucugguauaccaguugucccaccaggggcacggcuggauagccacguucggacaggauaaccgcugaaagcaucuaagcgggaaaccucuuccaagaccaggcuucucacccucuaggagggauaaggccccccgcagaccacgggauugauagaccagaccuggaagccuaguaauaggugcagggaacuggcacuaaccggccgaaaacuua <<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<<......<<<<<<.[[.(((.>>>.....<<<<<<<..<<<)))..]].>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<.....>>..<<<<<<.....<<.....>>....>>>>>>...<<<....<<<<<<<<<<............<<.....>>>>>>>>>>......<<<<..[.....<<<<<<.>>>>>>>><<<<<<.......<<<<<<.<<<<.<<<.....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>>>.....]...>>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..>>>......>>.>>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<<..>>.>>>>>..>>>>...<.<........>.>.<<<<<<....<<<.<<<<<<<<<<..<<<...<<<....>>>...>>>...<<....>>..<<<<.....>>>>....<<<<<<<....>>>>>>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<....<<<<<<<<.....<<<....<<<.<<<<....<<<<<<..>>>>>.>....>>>>.>>>..>>.>.....>>>>>>>>.......>>>>>>>.>>..<<<<<<<<<<......>>>>>>.>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>...........)))......>>>>>>.>>>...>>>>>>><<<<<<<<..>>>>>>>>....>>>>>><.<<<<<<<<<<......<<<<<<<<....>>>.>>>>>...>>>>>>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<.......<<<<..<<<<<<<<......<<<<.<<.....<<<.....<...<.<....>.>...>.....>>>.....>>.>>>>.....>>>>>>>>....>>>>.<<...<<<<<...<<<<..<<<..<<<<..<<<<<...((((...>>>>>.<<..<<<<...<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>...>>>>...>><<.<<<....>>>..>>.>>>>...>>>...>>>>........>>>>>..>>....>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<<...<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<...<<<<....<<<..>>>....>>>>..>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.<<<....<<<<<.<<<<<<...>>>>>>..>>>>>....>>>.>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>>>>>>>>.....>.((..<<<<<......))>>>>>..<<<<<<<<.<<<.<<......<<<<<<<<<<..<<<<<.<<<.<<<<<.<<.<<<<<<<<<<<<<.............<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>....>>>>>>>>>>>>>.>>...<<<.<<<<<<......>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.<<..>>>>..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<.<<<<...<<.......>>...>>>>.>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))))>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<...>>>>>....<<<<.<<<<.......>>>>.....<<<.<<<<.<<<....<<<<<....>>>>>...>>>..>>>>..>>>...>>>>....>>>>. ((((......((((((((((.....(((..(((((((((((((......((((((.[[.[[[.))).....((((((...(((]]]..]].)))......))))))...)))....(((....)))(((((((......))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))....((([...(((((.(((.............[[......))).)))))....(.((((.(....(.((((((.]])))))).(((((.......((((((.((((.(((...(.((((......)))))[[(...).(((.....]])))...)))...)))))))))))))))..).....).))))]....(((((((...[.......)))))))....).(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((..(((((((())).)))))..)))).<.(.(........).).((((((..(.(((.((((((((((..(((...(((....)))...)))...((....))..((((.....))))....(((((((....)))))))....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......A))))))))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))(((((((((.([.((((((((.....(((....(((.((((....(.((((..))))..)....)))).)))..)).).....))))))))....).]))))))).))..((((((((((......)))))).))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.((([.(((.........)))..))).....(]..((......)).).)))))...)))))))))).))...........]]].)....))))))))))...)))))))((((((((..))))))))....))))))(.((((((((((......((((((((....))).)))))...))))))))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]]((((((((((.(.....(((...(.(((((.......((((.((..................(......)..................)).))))......))))).).....))).((...(((((...((((..(((..((((..(((((....{{{...))))).((..(((....(((((.(((((.((.....))))))).).....))))..[.)))...))(..(((....)))...).))))...)))...))))(..)....)))))..))..).)))))))))))))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((...((((....(((.])))....))))..))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((....(....((((..((.(((...))).))...))))....)....))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....))[[..(((((.....>]])))))..((((((((.(((.((......((((((((((..(((((.(((.(((((.((.((((((((((.(..(..........((((...((......((((((((....))))))))...)).............)))).)..).)))))))))).))...(((.((((((......)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.(.((((...((.......))...)))).)...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))..a.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..(((((...)))))....((((.((((.......)))).....(((.((((.(((....(((((....)))))...)))..))))..)))...))))....)))). M. smegmatis P/P state 50S ribosomal subunit; 23S rRNA 5zeu a 1506 3.7 RF00177,RF01959,RF01960 URS00001AF2F7_246196 30206241 0003735 0005840 246196 uggagaguuugauccuggcucaggacgaacgcuggcggcgugcuuaacacaugcaagucgaacggaaaggcccuuucggggguacucgaguggcgaacgggugaguaacacgugggugaucugcccugcacuuugggauaagccugggaaacugggucuaauaccgaauacacccugcuggucgcauggccugguaggggaaagcuuuugcggugugggaugggcccgcggccuaucagcuuguugguggggugauggccuaccaaggcgacgacggguagccggccugagagggugaccggccacacugggacugagauacggcccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagcgacgccgcgugagggaugacggccuucggguuguaaaccucuuucagcacagacgaagcgcaagugacgguaugugcagaagaaggaccggccaacuacgugccagcagccgcgguaauacguaggguccgagcguuguccggaauuacugggcguaaagagcucguaggugguuugucgcguuguucgugaaaacucacagcuuaacugugggcgugcgggcgauacgggcagacuagaguacugcaggggagacuggaauuccugguguagcgguggaaugcgcagauaucaggaggaacaccgguggcgaaggcgggucucugggcaguaacugacgcugaggagcgaaagcguggggagcgaacaggauuagauacccugguaguccacgccguaaacgguggguacuagguguggguuuccuugggauccgugccguagcuaacgcauuaaguaccccgccuggggaguacggccgcaaggcuaaaacucaaaggaauugacgggggcccgcacaagcggcggagcauguggauuaauucgaugcaacgcgaagaaccuuaccuggguuugacaugcacaggacgccggcagagaugucgguucccuuguggccugugugcagguggugcauggcugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuugucucauguugccagcacguuaugguggggacucgugagagacugccggggucaacucggaggaagguggggaugacgucaagucaucaugccccuuauguccagggcuucacacaugcuacaauggccgguacaaagggcugcgaugccgugagguggagcgaauccuuucaaagccggucucaguucggaucggggucugcaacucgaccccgugaagucggagucgcuaguaaucgcagaucagcaacgcugcggugaauacguucccgggccuuguacacaccgcccgucacgucaugaaagucgguaacacccgaagccgguggccuaacccuuguggagggagccgucgaaggugggaucggcgauugggacgaagucguaacaagguagccguaccggaaggugcggcuggauca ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<..<<<<<<<....>>>>>.>>>..>>>>>......<<........<<<<<<<..<<...<<<<<<<<<<<<.....<<<<<......>>>>>......>>>>.....<<<<<<<<<<<<..>>>>>.>>>>>>>....<<....>>>>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<<....>>.......>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<.....<<<<<<<.....>>>>>>>...>>>>>>>..>>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<<..<<<......>>>.....>>>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<...>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>.<<.....>>.>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<<..<<<......>>>>>.....>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>......>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<..<<<<....<.<<<<..<<<..<<.....>>.>>>.>>>>.>...>>>>..>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((....))))).)))..)))))......(((.......(((((((..((...(((((((.((((.....((((((....))))))......)))).....(((((((((((....)))).)))))))....((....)).)))))))..))))))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(..((....))..)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((.....(((((((.....)))))))...))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((.(...).))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((...(((((((....))))))).((.....))).))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((.(...((..(((......)))))....).)))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((..((...(((....)))...))....)))......)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((..((((....(.((((..(((..(((..).)).))).)))).)...))))..))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... M. smegmatis P/P state 30S ribosomal subunit; 16S rRNA 5zeu v 77 3.7 RF00005 URS00001BBAFC_562 30206241 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaagaucgucgguucaaauccggcccccgcaacca .<<<<<...<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>.>>>>>..... .(((((...((((......[..)))).(((((.......))))).....(((((..]....))))).)))))..... M. smegmatis P/P state 30S ribosomal subunit; P-tRNAfMet 5zey B 77 12.5 RF00005 URS00001BBAFC_562 30206241 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaagaucgucgguucaaauccggcccccgcaacca .<<<<<...<<<<.........>>>>.<<<<<.......>>>>>......<<<<.......>>>>..>>>>>..... .(((((...((((......[..))))..((.(.......).))......(.(((..]....))).).)))))..... M. smegmatis Trans-translation state 70S ribosome; A-tRNAfMet 5zlu G 1514 3.6 RF00177,RF01959,RF01960 URS0000D7794C_300852 29712846 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugcccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucaccuccuuu ....(((.....<<<<..))).<<<<.<<<<<...<<<<<<..........<<<...<<..<<..<<<<<<<<.......>>>>>>>>..>>>>.......<<.......<<<<<<<...<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>....<<<<.<<<<<....>>>>>.>>>>...<<<<...>>>>.>>>>>>>..>>.>>>>>>><<<....<<....<<<<<<<.......>>>>>>>..>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>.........<<.<<<....<<<<....>>>>..>>>>>.>.>>>>>...<<<<......<<<<<..>>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<((....<<<<<.........)).........>>>>>>>>>>..>>>>>>>>>..........<<.(......<<<<...<<<..<<<<<.<<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>....<<<<<<.<...<<<<<<<....<...<<<....<<<......>>>.......>>>....>..........<<....>>.>>>>>>>..>.>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<.......>>>>>>>>...<<...)>>.....>>>>>>..>>..<<......<<<<....>>>>....>>...>>>>...<<<..<<<<<<<.<<..<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<.<...<<..<<<<<........>>>>>...<<......>>...>>...>.>.<<<.<<<..<<<<<<.......<<<<<.<<<....>>>..<<<<......>>>>...>>>>>.....<<<<.<<<..<...<<...<<<.....>>>.>>....>..>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>.............<<<<<........>>>>>............>>>>>.....<<<<<<<..........>>>>>>>......>>...>>>>>>>.>>.>.....<..<<.<.<<<..<<<..<<<<<<<<<<<<<.....<<<<....<<<....>>>.>>>>....>>>>>>>>>>>>>..>>>..>>>..>.>>...>.....<<<<.<<<<....>>>>.>>>>.............. ....(((...[..[[...))).(((..(((((....(((((((......(.(((..(((.........((((.........)))).......)))......(((......(((((((...((...((((..(.(((((.....(((((....)))).).....)))))....((((...((......))...))))...((((...)))).)..))))..)).)))))))(((....((.....(((.((.......)).)))...))......)))..((((..((....)).....))))))).(((((............))))).((((....))))...))))...).....(.(((....(.((....).))..)))).)).))))....((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))........((([[[...(((((.....((.]]])).......))))))))....))))).)))..........((([[.....((((...(((...(((((.((.(((.(((......((((((.....))))))....))).)))...)))))))....(...((.(......(..(.(......((((....((........)).......)).)).....).......((....))...)..).....)))......))))...))))....((((((........((((.........)))).....))))))......{...((((((..((((.(((.(...).))).))))...((..]])).....)))))).))).(((......((((....))))....)))...]]..]((((..(((.(((.((..(((((..((((((((((......((........))..........(((((((..(...(.....((...((.(.........)))....(.........)..)).....)).((.(((...((((((......(((((((((....)))...((........))...)))))).....((((.(((..((...(....((.....)).).....))..)))..(...(..........)......)..)))).......).)))...)).)))))....)))))))..[)).)))))))).(...(.(((((.....(((..(((..(((....))).).))....))).....))))).)..............((............))..........)..))))).....(((((((.....]....)))))))......))...))).))).)).))..(.(..((.(.(..(.......((((((((((((...(.((((.....((....))..)))).)..))))))))))))........).)..).))...)..)..(((((((((....)))))))))}............. Ribosome Structure bound to ABC-F protein.; 16S ribosomal RNA 5zlu V 2875 3.6 RF02540,RF02541,RF00002 URS0000D7791D_300852 29712846 0003735 0005840 300852 aagaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaagccggucaccgcgcuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauagguagggugcccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaaccguugagcggaggcguagggaaaccgaguccgaacagggcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaugcggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgaggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccaauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccgggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccuccacggcgucaagccggaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucuu ..........<<<<<<<<<<<....<<<..<<<<<<<<<<<<......<<<<<<.[...((.>>>.....<<<<<<......))...]..........>>>>>>...>>>....<<<....>>><<<<<<.......>>>>>>.<<<<<......>>>>>.>>....<<<<<.....<......>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>.....<<...<<<<<<<<.....>>>>>>>>.......<.................<<<<<.<<<..<<<....<<<<......>>>>.((......<<<.....))>>>...>>>....>>>..>>>>>.............>.....<<<<<<<<<.......>>>>>>>>>.......<<<...((((.>>>...>>.......>>.>>>>>>.>>...............<<....>>....>>.........<<<......>>>.............>....>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<...<....<......>....>.................................>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<.....<<<<<<......>>>>>>......>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>...<.<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<....<<<...<<<<.<<<.........................>>.>>>>>..>>.>....>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<........>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<((......<<<<<<...........<<..<<<..<<<...........<.<.......<<.........>>...............<<......>>....>.>......>>>..>>>.>>...........)).......>>>>>>.>>>...>>>>>>>.<<<.<.........>.>>>.....>>.>.>....<<.....<<......<<<<<.<......>.>>>>>...>>....>>..........>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<..<<...<<<<<<...<.......>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>)).<<<<<<<<<<.....<<<.....<<<<..<<<..<<<<..<<<<.......[[......>>>>......<<<...<.<<<<<<<<.<.......>>>>>>>>.....>.>.>>>..........<.<<.....>>.>.......>>>>...>>>...>>>>.........>>>.........>>>>>>>>>>.>>>>..>>.....<<......>>.>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<..<..<<.......>>..>.>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<......>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.<<<.........<<<..<.<<<<..<<<<<.<<<.<.<<...<<<<<....<<<<.............................<<<<<<<<....>>>>>>>>...........................>>>>....>>>>>....<<<<<....>>>>>.....>>.>.>>>..>>>>>....<.......>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<....(((.>....>>>>>>>...<<.<..<<<......>>>..>.>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>...>.>>>.......<<<<....<<<<<...<<.......>>...>>>>.>....>>>.>.......<.<<<.<<<<<...<<<<<<<<<......>>>>>>..>>>.<<<<.......>>>>......>>>>..>...>>>..>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>.....<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<..]]..>>>>>...>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>..................<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>........ ............((((((((.....(((..((((((..((((......((((((.....[[.)))....(((((((.....(]].....)........)))))).).)))....(((....)))((.(...........).))..(((........)))..))...((((((.........[.........))))).).........(......)...(((((.....((.]...))....)))))...(......((((((((.....))))))))...................((....(.(((..(...(((.....(((......)))..[[(...).(((.....]])))...))).....)...))).)...))..............((.(..((.........))..).))......(((((..[[..)))))....)......))...)))).))...............((....))....))......(..(((......)))............)).....))))))))..........(.....((((....)))).....)....(.(........).).((((((....(((((((((((((..(...................)....(.....)....(.......).......)))))))))))))..((.(...((((((.....((((((((((.((.....((((((......))))))......))...(((...(((........)))..)))..).))))))))).(.(((.....)))...)..))))))......).))......((....(((((....)))))(((((((((.(...((.(((.(....(((...(((...((...((...............))....))..)))..)).).....))).)))...).))))))).))..(((((((.((......)).)))))))......((......))....((((.(((...(((..[...(.((((((...........((..(((......(.........(.(.......((.........).)..........(...((......)).)..).)....)......))).))...........]........))))))))))...))))))).((.(..(.....).)..)).....))........(((....((......(((((.(......).)))))...))...)))..........))))))(......((.....((((((.......))))))(..(....((((..(....(((.((....(.....)..)).)))....[[((((.((...(((...((......))...)))...))....((((........)))).]](((((((((((.(.....(.....(((((.(((..((......((.......{{......)).............(...(((.(((.(.......)))).)))........).................(....)............))...)))..)))))(..).....)......)....)))))))))))))))...).....((......)).)))).(((........)))..)..)..((((....((((((((.((.......(.......(((((....(.[..).....)))))((.(....((.(.....).))...).))(...).......(((((((((...(.(........))...((.((((.....(((....))).......)))).)).]((((.(((..(((((((..((....((...(..(.......).)...))....)))))))..)))))((((...........))))........((..........(((((.......)))))..)..)....))))...)).))))))).)...)).)))))))).)))))).....)..[..(((((......].)))))...(((((((.(((.........((((.((((((..(((((.(((..((((....(((....(((..............................(((((.((....)).)))))............................)).)...)))......(.(.........))....))))..)))..)))))...((......[)).(((.((..........])).)))([((...(((.(((.(.(((((.........)))))...).((][.[[[))....)).))))...((....(((...{..)))....)).(((....))).))]]].].....(((((((.((....]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((.(((..((((((((........)))))..))).(((((.....))))).....))).)..)...))).))....(((((((....))).))))........)))))))))).[.......(.(...((((..((((((......(....).....)))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..].....).).........................(.((.......)).).....((.(((((.(((....(.(((....))).)...)))..)))))..))............... Ribosome Structure bound to ABC-F protein.; 23S ribosomal RNA 5zlu X 123 3.6 RF00001 URS00001170B4_300852 29712846 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcgggggau ..<<<<<<<<<<<....<<<<<.<<....<<<<<<...............>>>..>>>...>>.>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>>. ..(((((((((((....(((((..(....(((((((...(.....)...))))..)))...)..))).))(((.......((((((((....)))))))).......))).))))))))))). Ribosome Structure bound to ABC-F protein.; 5S ribosomal RNA 5zlu DD 77 3.6 RF00005 URS0000D77933_300852 29712846 0030533 0006412 300852 cgcggggnggagcagcccgguagcucgucgggnacauaacccgaagnucgucggnucaaauccggcccccgcaacca ..<<<<<..<<<<.........>>>>.<<<<<.......>>>>.>....<<<<<.......>>>>>>>>>>...... ...((((..((((.........)))).((.((.......)).)).....(((((.......)))))))))....... Ribosome Structure bound to ABC-F protein.; P-site tRNA 5zwm F 99 3.4 RF00026 URS0000D7792B_559292 29794219 0030621 0000244,0000353 0005688,0046540 559292 guucgcgaaauuuuacuucguggacauuuggucaauuugaaacaauacagaaucagcaguuccccugcauaaggaugaaccgucaaagagauuuguuuu <<<<<<<<<.......>>>>>>>>>.........<<<......>>>..................................................... (((((((((.(...).))))))))).........(((......)))..................................................... Cryo-EM structure of the yeast pre-B complex at an average resolution of 3.4~4.6 angstrom (tri-snRNP and U2 snRNP Part); U6 snRNA 5zwm I 110 3.4 RF00015 URS00001143F5_559292 29794219 0017070 0000244,0000353 0005687,0046540 559292 auccuuaugcacgggaaauacgcauaucagugaggauucguccgagauuguguuuuugcugguuuaauuauaacuccucauggucagacuauguagggaauuuuuggaau ...................<<<<<.<<<.....<<<....>>>..>>>>>>>>.....................<<<<<<<<<<<.>>>>>>>.>>>>............ ...................(((((.(((.....(((....)))..))))))))......................((((((.(((.))).))).)))............. Cryo-EM structure of the yeast pre-B complex at an average resolution of 3.4~4.6 angstrom (tri-snRNP and U2 snRNP Part); U4 snRNA 5zwm B 175 3.4 RF00020 URS000053F313_559292 29794219 0000244,0000353 0005682,0046540 559292 aagcagcuuuacagaucaauggcggagggaggucaacaucaagaacugugggcgccuauagaacuuauaacgaacaugguucuugccuuuuaccagaaccauccggguguugucuccauagaaacagguaaagcuguccguuacugugggcuugccauauuuuuuggaacuuuuc ...<<<<<<.<<<<.......<<<<..<<<<<.<<<<<<<<<<..<<<<<<<..>>>>>>>..>>>.........<<<<<<<<...........>>>>>>>>...>>>>>>>>>>>>......<<<<......>>>>>>>>..>>>>>>>>.>>..................... ...((((.(.((((........(((..((((..(((((.((((..((.(.((())).).))..)))....((...((((((((.(.......).)))))))).))).))))).))))......((((......)))))))...))))).)).))..................... Cryo-EM structure of the yeast pre-B complex at an average resolution of 3.4~4.6 angstrom (tri-snRNP and U2 snRNP Part); U5 snRNA 5zwm G 44 3.4 29794219 559292 aaaaaaaaaaaacuagauacuaacacauuuaauuuuuuuuuguu ............................................ ............................................ Cryo-EM structure of the yeast pre-B complex at an average resolution of 3.4~4.6 angstrom (tri-snRNP and U2 snRNP Part); Pre-mRNA-BPS 5zwm H 206 3.4 RF00004 URS000023C730_559292 29794219 0045131 0000348 0005686 559292 gaaucucuuugaguguaguaucuguucuuuucaguguaacaacugaaaugaccuaggcucauacauuuuuuggcacggacgggaagaggguggcgcugcaagaggaaguuuuucgauuguugauuuuccuuuugaaguguccucgagacgucgcgacccucggagucguucuugacuuggucgcuugauguuucuucuucccguuc .............................<<<<<<......>>>>>>.<<<<<..>>.>>>................<<<<<<<<<<..<.<<<<<<.<<<<<<<<<<.<<..<<..>>..>>.>>>>>>>>>>.>>>>>>.>.<<<<<<<<<<<<.<<...<<<<<<....>>>>>>>>>>>>..>>>>>>>>.>>>>>>>>>>. .............................((((((......))))))((((((())).))))..............(.(((((((((.(..(.(.((.(((.(((((..(...(.().)...)..))))).))).)).).)..)((((((((((((.((....(((((....))))).))))))..)))))))).))))))))).) Cryo-EM structure of the yeast pre-B complex at an average resolution of 3.4~4.6 angstrom (tri-snRNP and U2 snRNP Part); U2 snRNA 5zwn G 22 3.4 29794219 559292 aaaaaaaaaagguauguauuaa ...................... ...................... Cryo-EM structure of the yeast pre-B complex at an average resolution of 3.3 angstrom (Part II: U1 snRNP region); pre-mRNA 5zwn P 480 3.4 RF00488 URS000012D749_559292 29794219 0030627 0000395 0005685 559292 auacuuaccuuaagauaucagaggaaaguccuacugaucaaacaugcgcuuccaauaguagaaggacguuaagcauuuaucauugaacuaguucauugaagucauugaugcaaacuccuuggucacacacacggcgcggaaggcguguuugcugacguuuccauucccuuguuucaaucauugguuaaucccuuuggguuaaacugauuuuuggggcccuuuguuucuucugccuggagaaguuugacaccaaauucaaauugguguuaggggagcuggggccuuucaaaagagcuuuguagaggcauucuuuuugacuacuuuucgcgugccauuuuaguuuuugacgauucgaaugaacuaguuuaugaugaaguugagauuauuuggucgauuguaguuugaagauguagucucaacuuugcucaaauuuuggaaggucuugguaggaacggguggaucuuauaauuuuugauuuau ...........<<<<.<<<<<<<<.....>>>.>>>>><<<<<<<<<.<<<<<........<<<<<.<<<..<<<<.<.<<<.<<<<<..>>>>>.>>>.......>>>>>.>>>>>>>>.................>>>>>>>>>>>>>><<<.<<<<.<<..<<<<<.<<<<<<<..<<<<<<<.<.<<<...>>>.>.>>>>>>>..>>>>>>>((.......<<<<<....))>>>>>...<<<<<<<<.......>>>>>>>>.>>>>><<<<<<<<<<<<<<<<<..<<...<<.<<<<<..<<<<<..<<<<<<..<<.....<<<<...<<<<<<..<<<..<<<<.<<<<<<<>>>>>>>..>>>>>>>.>>>>>>..>>>>.>>..>>>>>>.>>>>>....>>>>>.>>...>>.....>>>>>>>>>>>>>>>>>.>>>>>>..>>>.>>>>................ ...........((((((((((((((...)))).)))))(((((((((.(((((........(((((.(((..(((((..(((.((((....)))).)).)......))))).)))))))).(.(...........))))))))))))))))(((.((((.((..(((((((((((((..((..(((.(.(((...))).).)))..))..)))))))[[.......(((((....]])))))...(((((((.(......)))))))))))))).((((((((((.(((((..((...((.(((.(..((((....(((((..(....(..(((...((.(.(...((..(((..((.(((()))).))...)))))..).).))..))).).)..)))))...))))....).))).))...)).....))))).))))))))))..))))))..))))))))................ Cryo-EM structure of the yeast pre-B complex at an average resolution of 3.3 angstrom (Part II: U1 snRNP region); U1 snRNA 5zwo F 99 3.9 RF00026 URS0000D7792B_559292 29794219 0030621 0000244,0000353 0005688,0046540 559292 guucgcgaaauuuuacuucguggacauuuggucaauuugaaacaauacagaaucagcaguuccccugcauaaggaugaaccgucaaagagauuuguuuu <<<<<<<<<.......>>>>>>>>>.........<<<......>>>..................................................... (((((((((.(...).)))))))))..........((......))...................................................... Cryo-EM structure of the yeast B complex at average resolution of 3.9 angstrom; U6 snRNA 5zwo B 175 3.9 RF00020 URS000053F313_559292 29794219 0000244,0000353 0005682,0046540 559292 aagcagcuuuacagaucaauggcggagggaggucaacaucaagaacugugggcgccuauagaacuuauaacgaacaugguucuugccuuuuaccagaaccauccggguguugucuccauagaaacagguaaagcuguccguuacugugggcuugccauauuuuuuggaacuuuuc ...<<<<<<.<<<<.......<<<<..<<<<<.<<<<<<<<<<..<<<<<<<..>>>>>>>..>>>.........<<<<<<<<...........>>>>>>>>...>>>>>>>>>>>>......<<<<......>>>>>>>>..>>>>>>>>.>>..................... ...((((.(.((((........(((..(((((.((((((((((..((.(.((())).).))..)))....((...((((((((...........)))))))).))))))))))))))......((((......)))))))...))))).)).))..................... Cryo-EM structure of the yeast B complex at average resolution of 3.9 angstrom; U5 snRNA 5zwo I 110 3.9 RF00015 URS0000D77922_559292 29794219 0017070 0000244,0000353 0005687,0046540 559292 auccuuaugcacgggaaauacgcauaucagugaggauucguccgagauuguguuuuugcugguuuaauuauaacuccucauggucagacuauguagggaauuuuuggaau ...................<<<<<.<<<.....<<<....>>>..>>>>>>>>.....................<<<<<<<<<<<.>>>>>>>.>>>>............ ...................(((((.(((.....(((....)))..))))))))......................((((((.(((.))).))).)))............. Cryo-EM structure of the yeast B complex at average resolution of 3.9 angstrom; U4 snRNA 5zwo G 60 3.9 29794219 559292 aaaaaaaauuuuuuuuaaaaaaaaaaaacuagauacuaacacauuuaauuuuuuuuuguu ............................................................ ............................................................ Cryo-EM structure of the yeast B complex at average resolution of 3.9 angstrom; Pre-mRNA 5zwo H 150 3.9 RF00004 URS0000D77944_559292 29794219 0045131 0000348 0005686 559292 gaaucucuuugaguguaguaucuguucuuuucaguguaacaacugaaaugaccuaggcucauacauuuuuuggcacggacgggaagaggagacgucgcgacccucggagucguucuugacuuggucgcuugauguuucuucuucccguuc .............................<<<<<<......>>>>>><<<<<<..>>.>>>>...............<<<<<<<<<<.<<<<<<<<<<<<.<<...<<<<<<....>>>>>>>>>>>>..>>>>>>>>.>>>>>>>>>>. .............................((((((......))))))((((((())).))))..............(.(((((((((.((((((((((((.((....(((((....))))).))))))..)))))))).))))))))).) Cryo-EM structure of the yeast B complex at average resolution of 3.9 angstrom; U2 snRNA 6ah0 F 69 5.7 RF00026 URS00001EC8D7_9606 30315277 0030621 0000244,0000353 0005688,0046540 9606 gugcucgcuucggcagcacagaagauuagcauggccccugcgcaaggaugauucgugaagcguauuuuu <<<<<.<<....>>>>>>>.................................................. (((((.((....))))))).................................................. The Cryo-EM Structure of the Precusor of Human Pre-catalytic Spliceosome (pre-B complex); U6snRNA 6ah0 G 42 5.7 30315277 9606 uuuccuugaugaugucauacuuauccugucccuuuuuuuucc .......................................... .......................................... The Cryo-EM Structure of the Precusor of Human Pre-catalytic Spliceosome (pre-B complex); pre-mRNA 6ah0 H 109 5.7 RF00004 URS00003EE995_9606 30315277 0045131 0000348 0005686 9606 cgcuucucggccaguguaguaucuguucuuaucaguuuaauaucugauggauuuuuggagcagggagccacgcaucgaccugguauugcaguaccuccaggaacggugc ..............................<<<<<........>>>>>...............<......><<<<<<.<<<<<.............>>>>>..>>>>>> ..............................(((((........)))))...............(..()..)(((.((.(((((.............)))))..)).))) The Cryo-EM Structure of the Precusor of Human Pre-catalytic Spliceosome (pre-B complex); U2snRNA 6ah0 I 117 5.7 RF00015 URS00003F07BD_9606 30315277 0017070 0000244,0000353 0005687,0046540 9606 agcuuugcgcaguggcaaucguagccaaugaggucuauccgaggcgcgauugcuaauugccgccgugacgacuugcaauauagucggcacuggcaauuuuugacagucucgagacug ..................<<<<.<<<.....<<.....>>..>>>>>>>............<<<<<<.<<<<<........>>>>>.>>>.>>>.........<<<<<<<>>>>>>> ..................(((..(((.....((.....))..))).)))............((((((.(((((........))))).))).))).........((((((())))))) The Cryo-EM Structure of the Precusor of Human Pre-catalytic Spliceosome (pre-B complex); U4snRNA 6ah3 A 369 3.48 RF00009 URS0000413C32_559292 30262633 3.1.26.5 0004526 0008033 0030677 559292 guggaacagugguaauuccuacgauuaagaaaccuguuuacagaaggauccccaccuaugggcggguuaucagauauuaucaggugggaaauucgguggaacacaguggagccuuguccuccggguuaaugucgcuuuuggcauuggccccugcuccugagagaagaaauauacuggggaaccagucuuuaccgaccguuguuaucagaaauucacggaguucggccuaggucggacuccgaugggaacggcaacgguuguuccguuugacuugucgcccgcuacggcgugagcgucaaggucuguugagugcaaucguaggacgucauuaguggcgaacccgauaccgauuacugcugcuguuccagc .<<<<<<<<<<<<<..<<<<<<<........<<<<<..........<<<.<<<.<<....>>.>>>..>>>.........>>>>>[[...{{.(((((........<<<<<<.........<<<<<<<<<<<<<....>>>>>>>>>>>>...<<....>>.<<........<<<<<....>>>>>.>>....>..<<<<<<.............<<<<<<<<<<......>>>>>>>>>>.........>>>>>>...>>>>>>...<<<<<<.<<<.<<<....>>>...>>>.>>>.>>>.............>>>>>>><<<<<....>>>>>..]]...)))))}}...>>>>>>>>>>>>>.. .(((((((((((.(..(((((((........(((((..........(((.(((.((....)).)))..))).........))))).{...[[.[[[[.....[....(((.((..)......(((..((((.(......).))))..)))...((....))..(........(((((....))))).)........(((((...............(((((.((.(....).)).)))))...........)))))..]).)))....((((((.(((((((....))).).))).))).))).............)))))))((.((....)).))..}.....]]]]]]...).))))))))))).. Cryo-EM structure of yeast Ribonuclease P with pre-tRNA substrate; Ribonuclease P RNA 6ah3 T 80 3.48 RF00005 URS0000D77911_559292 30262633 0030533 0006412 559292 agaagcggauuuagcucaguugggagagcgccagacugaagaucuggagguccuguguucgauccacagaauucgcauuu ....<<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... ....(((((((..((((.....[..)))).((((.........)))).....(((((..]....)))))))))))).... Cryo-EM structure of yeast Ribonuclease P with pre-tRNA substrate; pre-tRNA 6ahd I 136 3.8 RF00015 URS00003F07BD_9606 30315277 0017070 0000244,0000353 0005687,0046540 9606 agcuuugcgcaguggcaguaucguagccaaugaggucuauccgaggcgcgauuauugcuaauuacuuuucccaauaccccgccgugacgacuugcaauauagucggcacuggcaauuuuugacagucucgagacug ...................<<<<<.<<<.....<<.....>>..>>>>>>>>............................<<<<<<.<<<<<........>>>>>.>>>.>>>.........<<<<<<<>>>>>>> ...................(((((.(((.....((.....))..))))))))............................((((((.(((((........))))).))).)))..........(((((()))))). The Cryo-EM Structure of Human Pre-catalytic Spliceosome (B complex) at 3.8 angstrom resolution; U4snRNA 6ahd B 115 3.8 RF00020 URS000075BAAE_9606 30315277 0000244,0000353 0005682,0046540 9606 acucugguuucucuucagaucgcauaaaucuuucgccuuuuacuaaagauuuccguggagaggaacaacucugagucuuaacccaauuuuuugaggccuugcuuuggcaaggcua .<<<...<<<<<<<<<<........<<<<<<<<...........>>>>>>>>...>>>>>>>>>>.......>>>...................<<<<<<<<....>>>>>>>>. .(((...((((((((((........((((((((.(.......).))))))))...)))))))))).......)))....................(((((((....))))))).. The Cryo-EM Structure of Human Pre-catalytic Spliceosome (B complex) at 3.8 angstrom resolution; U5snRNA 6ahd F 94 3.8 RF00026 URS00001EC8D7_9606 30315277 0030621 0000244,0000353 0005688,0046540 9606 gugcucgcuucggcagcacauauacuaaaauuggaacgauacagagaagauuagcauggccccugcgcaaggaugacauucgugaagcguauuu <<<<<.<<....>>>>>>>........................................................................... (((((.((....)))))))........................................................................... The Cryo-EM Structure of Human Pre-catalytic Spliceosome (B complex) at 3.8 angstrom resolution; U6snRNA 6ahd G 77 3.8 30315277 9606 ggccuccgaacgguaagagccuagcauguagaacuuuuccuugaugaugucauacuuauccugucccuuuuuuuucc ............................................................................. ............................................................................. The Cryo-EM Structure of Human Pre-catalytic Spliceosome (B complex) at 3.8 angstrom resolution; pre-mRNA 6ahd H 109 3.8 RF00004 URS00003EE995_9606 30315277 0045131 0000348 0005686 9606 cgcuucucggccaguguaguaucuguucuuaucaguuuaauaucugauggauuuuuggagcagggagccacgcaucgaccugguauugcaguaccuccaggaacggugc ..............................<<<<<........>>>>>...............<......><<<<<<.<<<<<.............>>>>>..>>>>>> ..............................(((((........)))))...............(..()..)(((.((.(((((.............)))))..)).))) The Cryo-EM Structure of Human Pre-catalytic Spliceosome (B complex) at 3.8 angstrom resolution; U2snRNA 6ahu A 341 3.66 RF00009 URS000013F331_9606 30454648 3.1.26.5 0004526 0008033 0030677 9606 auagggcggagggaagcucaucaguggggccacgagcugagugcguccugucacuccacucccaugucccuugggaaggucugagacuagggccagaggcggcccuaacagggcucucccugagcuucggggaggugaguucccagagaacggggcuccgcgcgaggucagacugggcaggagaugccguggaccccgcccuucggggaggggcccggcggaugccuccuuugccggagcuuggaacagacucacggccagcgaagugaguucaauggcugaggugagguaccccgcaggggaccucauaacccaauucagacuacucuccuccgcccauu <<.<<<<<<<<<.<<.((((.{...<<<<..........<<<<........>>>>............>>>>.[[...<<<<<<<<.....<<<<......<<<<<.....>>>>><<<<<<<.....>>>>>>><<<<<<<.............<<<<<<.<<<<<<.......<<<<<.....<<<<<.<<.<<<<.<<<....>>>.>>>>>>>>>>>..>>>>>>>>>.>>>>>>>>........>>>>>>>>>>>..................}.))))<<<<<<<.<<<<...>>>>>>>>>>>..]]...>>>>>>>>..>.>>>>>>>>>>>>. ((.((((((((..(((((((.(...(((((........((((((.....).)))).)........).)))).........[[[[......((((......(((((.....)))))(((((((.....)))))))(((((((.............((((((.((.(((.......(((((......((((.((.((((.(((....))).))))))))))...))))))))..))))))))........))))))))))).................[).))))(((((((.(((.....))))))))))...]....]]]]....)).).)))))))))). Cryo-EM structure of human Ribonuclease P with mature tRNA; H1 RNA 6ahu T 72 3.66 RF00005 URS0000E60B72_9606 30454648 0030533 9606 guuuccguaguguagugguuaucacguucgccuaacacgcgaaagguccccgguucgaaaccgggcggaaac <<<<<<<..<<<..........>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>> (((.(((..(((..........))).(((((.......))))).....(((((.......)))))))).))) Cryo-EM structure of human Ribonuclease P with mature tRNA; tRNA 6az1 1 1760 2.7 RF01960,RF01959,RF00177 URS0000CBFF3E_5661 29150609 0003735 0005840 5661 gaucuggnugauucugcnaguagucaunugcunguuunaaggacuuagccaugcaugccucagaaucacugcagcaggaaucugcgcauggcucnuuacaucagacguaaunugccgcaaaaaucuugcgguccgcaaaauuggauaacuuggcgaaacgccaagcuaauacaugaaccaaccgggugucuccagagacgcccagcgaaugaaugacaaaaccaaugccugcaguaacacccagcaguguugacucaauucauuccgugcgaaagccggcccggcgucuuuugacgaacaacugcccuaucagcuggugauggccguguaguggacugccauggcguugacgggagcgggggauuaggguucgauuccggagagggagccugagaaauagcuaccacuucuacggagggcagcaggcgcgcnaauugcccaaugucaaaacaaaacgaugangcagcgaaaagaaauagaguuuucaaugggggauauuuaaacccauccaauaucgaguaacaauuggaggacaagucuggugccagcacccgcgguaauuccagcuccaaaagcguauauuaaugcugungcuguunaaggguucguaguugaacugugggcuguucccguccauucggaugacccugcagcccgugaacagaaacaacgggagugggggcguccgugauuuuuuacugugacuaaagaagcgugacuaaagcagucaugacugaauuagaaagcaugggauaacaanggagcaguuuuaaaggucuauuggagauuauggagcugugcgacaagugcuuucccauaggaaugaaggaggguagucgggggagaacguacuggggcgucagaggugaaauucuuagaccgcaccaagacgaacuacagcgaaggcauucuucaaggauaccuuccucaaucaagaaccaaaguguggagaucgaagaugauuagagaccauuguaguccacacugcaaacgaugacacccaugaauuggggauccuuacguaucuuucucagcacguuuucuguuuucacgcgaaagcuuugagguuacagucucagggggnaguacguucgcaanagugaaacuuaaagaaauugacggaauggcaccacaagacguggagcgugcgguuuaauungacnnaacacngggaacuuuaccagauccggacaggaugaggauugacagauugaguguucuuucucgauucccugaauggngnugcauggccgcuuuuggucggugnagugauuuguuugguugauuccgucaacggacgagauccaagcugcccaguagaauucagaauugcccauaggauaggcauucgucgaauucuncucugcgggauuccuuguaaugcacaaggugaaauuuugggcaacagcangucngugaugcuccucaauguucugggcgacacgcnnacuacaaugucagugagaacaagaaaaacgagucgaaccuacuugaucaaaagaguggggaaaccccggaaucacauagacucacuugggaccgaggauugcaauuanuggucgcgcaacgagnaaugucucguaggcgcagcucaucanacugugccgauuacgucccugccauunguacacaccgncngucguuguuuccgaugauggugcaauacaggugaucggacgaaaguucaccgauauuunuucaauagagnaagcaaaagucguaacaagguagcuguaggugnnccugcagcuggaucauuu ...<<<<<.{.((((>>>>><<<<.<<<<<<...<<<...<......<<<.<<<..<<....<<....<<<<.>>>>...>>.>>......<<..<.....<<<..<<..<<...<<.<<.....<<<<<<.>>>>>>...<<.....<<<<<<.....>>>>>>......>>..........<<<<<<<<<..>>>>>>>>>.<<<<<<<<<<.....((.{....<..>..........................>>>>>>>>...>>....<<<<<.>>>>>...>>.>>..>>>>..>>>.<<<....<<<....<<<<<.<<.......>>.>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>>>>.<<.<<<..........>>>.>>.<<<<....>>>>...>>>>>>.........<<<....<<<..........>>>..>>>..>....>>>....<<<..>>>.....<<<<............>>>.....>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>>>>>.........<<<[[.....<<<<...<<<..<....<...<<.<<....<......>..>>...>>...>.........................................<<<<<<<<.......<<...<.......>..<<<..>>>....>>......>>>>>..>>>..........<<<.<..<<...<......}.))...>..>>..>.>>>...................>......<<<<<.<<...<<<<<<<<..<<<<.<<<...<<<......>>>......>>>.>>>.>.>>.......<<....>>.>>>>>>...>>>>>.>>....>>>...>>>>...<<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>>.........<<<.<<...<..<.<<<<<..........<.<......>.>..>>>>>.>..>....<<..]]>>.....>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..)))).}<<<<<.<<<<<<<..<<.<<<<<<..<<.<<<<<<<......<<........>>..........<<<<<......<<<<.........<<.<<<........>>>.>>.......>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<<<.....<<<<<<<.<<<<................>>>>...>>>>>>>.....>>>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>.......>>>>>...>>.>>>>>.>>.....<<<.<<<.......<.....<<<.>>>..<<<<<<<........>>>>>>>....>........>>>...>>>......<....<<<..<..........>..>>>.....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<<<<<..<<.<<<.<.<<<<..<<<<<.<........>.>>>>>..>>>>.>.>>>.>>..>>>>>>>>..>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))((((.((((((...(((...((.....(((.(((..((....((....((((.))))...))[))......(((.......(((..((..((...((.((.....((((((.))))))....(.....((((((.....))))))......)...........(((((((((..))))))))).((((((((((.....{{.{.........................(......).))))))))...))....(((((.)))))...)).))..))))..))).(.(....(((....(((((.((.......)).))))))))......).)..(((.((((....))))....)))))).((.(((..........))).)).((((....))))...)))))).).....(.(((...((((.]........))).))))).)....)))....(((..))).....((((............))).....).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..[......((([[...(.((((...(((..(....(......(................)........)....................(.........)..........((.(((((.......((..((.......)).(((..)))....))......)))))...))........(.(((..(.((..........}.}}......)).)..)))...............)...)....(.(.(((.((...(((((((((..(((.(((...((........))......))).)))..))).......((....)).))))))..)).)))..)...))))...))))....((((((....(...((((.........))))...).))))))......{...(((.((......(.((..(..........(..........)..)..)).).......((..]])).....))...].))))))).(((......(.((....)).)....)))...]]].](((((.(((((((..((..(((((..((.(((((((.......(........)...........(((((.(....((((......(..((.(((........))).))....)..))))...((.(((...(.((((((....(((.(((((....)))....((......))....)).))).....((((.((((..(..(((((((.((((................))))...)))))))..)..))))..(.((((((.....))))))....)..)))).....))).))).....).))))).....).)))))...)).))))).)).(...(((((((.......(......((.))...(((((((........)))))))....)........))).).)))......(....(((..(..........)..))).....)..)..))))).....(((.(((.........))).)))......))...)))))))))).))..(.(..((.(.((((((((..((.((..(.(((((.(((((.(...()...).)))))).)))).)..)).))..))))))))..).))...)..)..(((((((((....)))))))))}........ Cryo-EM structure of the small subunit of Leishmania ribosome bound to paromomycin; ribosomal RNA 18S 6az1 2 76 2.7 RF00005 URS000080E264_562 29150609 0030533 0006412 562 gcgcggauagcucagucgguagagcaggggauugaanauccccguguccuugguucgauuccgaguccgcgcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>......<<<<.......>>>>.>>>>>>>.... ((((((...(((..........))).(((((.......)))))......(.............)..)))))).... Cryo-EM structure of the small subunit of Leishmania ribosome bound to paromomycin; tRNA-Phe 6az1 3 77 2.7 RF00005 URS00001BBAFC_562 29150609 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaagaucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).......(((.......)))..))))))..... Cryo-EM structure of the small subunit of Leishmania ribosome bound to paromomycin; P-site tRNA 6az1 4 76 2.7 RF00005 URS000080E264_562 29150609 0030533 0006412 562 gcgcggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgcgcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... .(((((....(((........)))..(((((.......)))))......((((.......))))..)))))..... Cryo-EM structure of the small subunit of Leishmania ribosome bound to paromomycin; E-site tRNA 6az1 5 12 2.7 URS00021ED951_3039 29150609 5661 caccauguucaa ............ ............ Cryo-EM structure of the small subunit of Leishmania ribosome bound to paromomycin; mRNA 6az3 1 1620 2.5 RF02543,RF02540 URS0000CBFF5D_5661 29150609 0003735 0005840 5661 agaccugaguguggcaggacuacccgccgaacuuaagcauauuacncagcggaggaaaagaaaacanccgugauucucucagugagcggcgagcgaagagggaacgaacucguugccgaaucgggucuuacaaggccuugaguuguggcacaaauaucauuucgugguuggugcaggaguggcgaaauucaagcgcaaagcaaacccguugcugaauacaacccuucaugugnguauugagccaaagaagguguuagcccauugagccauaaaccugagcgccucaugaacaagcgaguagcacuguuugggaaugcagugucaaguggcagguauuugucugccaaaguuaaauacagaguaggaagaccgauagcgaacaaguagcgugagcgaaaguuugaaaagcacuuuggaaagagaguganauagaaccugaagucgugacaaagacaauggaaguaccuccauuucaacggccagaaccagcccuacugcauuauccugucgggggucaaaauccggcgggcaagaagugcaagaagggucuuggugaaaugagcggaguauuugagcugugcacggcgcgcacgcacucuucuccgugaugcuccauguuggcgaugaaauggggugcccccacccgucuuganacncggaccaaggagunanacagacgcgcaagggaggagauaugguugccaguacuuucucguacugaaagggagaugcaaaaugcaucuguggugugcacacgucauuugcccaacaccgaccggcccuccguggguugcguuggagugugccngnuuggacccnanagguggugaacuaugccugaacaaggugaagcccggggaaacccagguggaggccuguagcgaugcugncgugcaaaucgcucguaugauuugggunucgnagcgaaagacucaucgaaccaccuaguagcugguucacaucgaaguuucccucaggauagcuggugcuaguagaaguauugugcgguaaagcaaaugauuagaggcauugggaccuauucucaaacuuuaaangugcaaacaaaccggccuuagccaacugcaaggccggaaagaaaagaauuagaggcaccaagugggccuucuucgguaagcngagcaggcgaugcggaaugaaccgcuuagggauauguggcgucaaaacuuaugggcucauucncgauacguaaaggguguugguggauauccaccggccccgaaaauggangacgcuuaagcccaauuagugauugcccauuauuccuuugguaagggcggaaacaaaggagaaaguguagcccuuccgauguagauguggccuggagguuaggacgaagcuuauggcgugagccuaagauggaccggccucuagugcanaunuugguuggcgunncaaagaucuaacggagauauacucaacaugcaacguuggauacuggagcggggaaggauuucgugccaacggcacucguacacganuuguucggaaacugagcacaacguuauaucgunuuguuaggaaagugaagguggucggccauaacugaaaaggggcaacagagaaccugggauuauauuccaaaaagaaauugcauguggg ......................<<<<<......<<....>>.......>>>>.>.........<<....>>..<<<<<<......<<.....>>....>>>>>>...<<<...<<<<<..<<<<<<<......>>>>>.>>....>>>>>..........<<<<<<...<<<<<<<<.<<<<<......<<<......<<<<.......>>>>.....<<........>>......>>>.<<.......((.....>>)).....>>>>>...>>>..>>>>>.>>>>>>..........<<<<<<<........>>>>>>>.....<<<<<........>>>>>..>>>....................................<<....>>................<<<......>>>..................................(((..<<<<<<.<<<<<<..((.<<<<.<<<<<<<<<...<<<<...<<<<<<<<<........>>>>>>>>>.....>.>>>....>>>>>..>>>>........<<<<<.....<<...<<<<.<<...>>...>>>>>>..>>>>>.....<<<<...>>>>))..>>>>>>>>>>>>..))).<<<<........>>>><<<<<<...<<<<<<<<.<<<<<..<<<.<<<<.<............>>>>>>>>...<<....>>..<<<<<.....>>>>>...<<<<<...<<.<...>.>>....>>>>><<<<<<<<<.....>>>>>>.>>>...>>>>>.>>>>>>>>.<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<.<<<....>>>.>>>.....>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>...<<<<<....<.<<<....>>>.><<<<<<<<<.....<<...<<<<<<<...<<<....<<<....<<<...<..>.>>>....>>>..>.>>...>>>>>>>.....<<<<<<<<.<<.....>>>>>>>>>>...........>>...>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>...<<<<......>>>>..<<<<<<<...<<<(((......<..<<<<........<.........<<<.<<<<<<<<<..>>>>>>>>>>>>..........))).>....>>>>.>.........>>>...>>>>>>>((((.<<<<<..........>>>>.........>>>>>))))....>>>>>....<<<<<<<<.........<<<..<<<....>>>.>>>.......>>>>>>>>........>>>>>>..............<<<<<<<....................>>>>>>>....................<<<<<....<<.....>>..>>>>>....<<..........<<.<<<<<......>>>>............<..<<.<..........>.>>..>...>.>>..........<<<<.........>>....>>.>>........... ......................(((((......(...[..).......)))).).........((....))...((((.......((.]...)).....))))....((((..((((..((((((((......))))).))....)))))..........((((((...((((((((.(((((....({(((......((((.......)))).....((........))......))))(((...).<[[....}))]].....)))))...)))..))))).)))))).....)....(((((((........))))))).....(((((........)))))..)))....................................((....)).............(..((((....))))............)......................((..((((((.((((((..((.((((.((((((((....((.((..((((((((..........))))))))....))..)).....))))..))))........(((((.....((...((((.(.....)...))))))..))))).....[[[....))))))..))))))))))))..))..((((........))))((((((....(((((((.(((((..(((..(((.((....>.....))))).)))...((....))..(((((.....)))))...(((((...((.(...).))....)))))(((((((((.....)))))).)))...))))).)))))))..((.(...((((((.....((((((((((.((((...(((.(((....))).)))...).)))...(((..((.((........)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)(((((((((.....((.(.((((((....(((....(((..(.(((........))).)..)))..)).)....)))))).....(((.((((.((.....)))))).)))..........)))...))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(..(..((((........(.........(((.(((((((((()))))))))))))..........]]].)....)))).))........)))...)))))))((((.((((((..........]]]...).....)))))))))....))))).)(.((((((((.(......((((..(((....))).))).)...).))))))))..).....))))))..............(((((((....................)))))))....................(((((....((.....))..)))))....((......(...((.(.(((......))).................(.(..........).).......).))....).....((((.........))....)).))........... Cryo-EM structure of of the large subunit of Leishmania ribosome bound to paromomycin; rRNA alpha 6az3 2 1078 2.5 RF02543,RF02540 URS0000CBFF59_5661 29150609 0003735 0005840 5661 cccaacugcagaccguacucaucaccgcaucagguccccaagcauagaaugcucugguacauagagaaangnacacucagggaagucggcaaaauagaugcguaaguucgcaagaagcauuggcucugagggcaaaaauugccaacucagaacugnuuacggcggggaauccaacugunuaauuaaaacauagguuugugaugcauccaagugguguauaucgcaaacugauuucugccnagugcucugugucaacgugacgagauucaccgacgcgcggguaaacggcgggaguancuaugacucucuuaagguagccaanugccucnucuuccaauuagagacgcgcaugaanggauuaaugngnuucccucugunccgaguuncuaucuagcgaancgacagucaagggaacggacuugnagggcuaagcggngaaagaagacccunuugaguuugncnccagucuggcucugugcggcgagcuucacuuaucgaaugaagagaccaauggguuuagcguagucuuggcuaugcaccgucuagguuuccgugcuguaaacugaaccaacgggaaguuccggagucuuguuucgagacaucugccagauggggaguuuggcugnggcggcauaucuguuacacgncaacgcaggnnuccuaaggcgagcucagugggaacagaaaucucacguagaacacaagcguaaaagcuugcuugauuaacgauunccaguangaaucgagacugcgaaagcaaggccngcgauccuuugcgaagaauaggaaauaugaacaaaucauaccanangugucagaauaauuacnacagngauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggnucuuccuaaccuagcgccgcagaagacgcuaaggguuggaunnuucacccacugncagggaacgugngcuggguuuagancgucgugagacagguugguuunacccuacuuagcuggaaauugcgagaaaaagauuauccguaagcggacgugcgagcgguggguguacgguacgcucacc ........................<<......>>......<<<<<...>>>>>........<<<<....<<<<.<<<<.<<...............<<<<<....<....>.....>>>>><<.<<<<<<<<<<<...>>>>>..>>>>>>.>>..........<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>.<.<<..<<<..<<<<<<.<<<<....<<<<......>>>>....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>.>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>............<<<<<........>>>>>..<<<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<...<<<.<<<..>>>.>>>...<<<<<.....<<<<...........<.<<<..........>>>.>................................<<<<....>>>>..>>>>...>>>>>.......>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<......>>....>>>>>>>...<<...<<<<<.......>>>>>..>>.<<<....>>>.>>........<<<<<<..............<<<<.......>>>>.>>>>>>.........>>>>..>>>>>>.......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<<<<<<<.<......>.>>>>..>>>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>>>......................<<.......>>.<.<>.>.<.<<.....<<<...>>>..>>.>. ........................((......))......((((.....))))........((((....((((.((((.((..(....(.......(((((....(.[..).....)))))((.((((((((.((...)).))..)))))).))..........(((((((((...((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((..(((....((((......))))....))).))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).)))).........[..(((((......].)))))..(((((((..(((.((......((((.((((((..(((((.(((((((...(((.(((..))).)))...(((((.....((((......(....(...(..........)...)).....(.......).................(((.(..).)))..))))...))))).......)))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][..[.))....))))))).(.((...(((((....{..)))))..)))(((....))).)).].].....(((((.(............((((.......))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(((((((.(......).))))..))).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))....))..))).))))))).......................(.......)..((())).(.((..(...((...))..))).). Cryo-EM structure of of the large subunit of Leishmania ribosome bound to paromomycin; rRNA beta 6az3 3 177 2.5 URS0000CBFF33_5661 29150609 5661 agugguaangcgaaacacugccagguaacaaaucaauccucccacggugagcuuucuuuucaccauaauccaccuugggccuuuuaccgcguuguucggagcgggggcucaagauugaaaaaugcagcucuacguacuguugugaguucugcgcauuaacgcaaaaaccuggggugu .<<......>>.....<<<.<<<<<<.......<<...<<<<...<<<<<<.......>>>>>><...<<.<.<<<<<<<<<<<...<<.......>>....>>>>>>>>>>>.>.>>....><<<<..<...>..>>>>.>.>>>...>>...............>>>>>>>>>.. .(((....))).....(((.((((((.......((...((((...((((((.......))))))(...((.(.(((((((((((...((.......))....))))))))))).).))....)((((..(().)..)))).).)))...))...............))))))))).. Cryo-EM structure of of the large subunit of Leishmania ribosome bound to paromomycin; rRNA gamma 6az3 4 183 2.5 RF02543,RF02540 URS000037206E_5661 29150609 0003735 0005840 5661 gugagauugugaagggaucucgcagguaucgugagggaaguaugggguaguacgagaggaacucccaugccgunccucuaguuucugggguuugucgaacggcaagugccccgaagccaucgcacggugguucucggcugaacgccucuaagccagaagccaaucccaagaccagaugcccac <<<<<<<.........>>>>>>>.<<<<<<....<<<<.<<<<<<<<...............>>>>>>>><<<<<...<.<<....<<<<<<<<<......>>>>..>>>>>...>>.>..>>>>>.<<<<....<<<<...........>>>>....>>>>.>>>>.......>>>>>>... (((((((.........))))))).(((((((...(((..(((((((......(....).....)))))))(((((...(.((....((((((((((....)))))..)))))...)).)..))))).((((....(((.............)))....))))..))).....).))))))... Cryo-EM structure of of the large subunit of Leishmania ribosome bound to paromomycin; rRNA delta 6az3 5 97 2.5 URS0000A76333_5661 29150609 5661 uacgucccucuccaaacgagagaacaugcaugggcuggcaugagcggggggcucgucccgaggcgcugaaccuugaggccucaugcucagggacaca ...<<<<<<<<<.......>>>>....<<<<<<<<.<<.....<<<...<<......>>....>>>....>>.....>>>.>>>>>...>>>>>... ...(((((((((.......))))....((((((((.((.....(((...((..()..))....)))....)).....))).)))))...)))))... Cryo-EM structure of of the large subunit of Leishmania ribosome bound to paromomycin; rRNA epsilon 6az3 6 71 2.5 URS0000CBFF43_5661 29150609 5661 aucgaaucgccaccuacaagacuggagcuugcucccucgaaggcgccaaguauauucaugaucacaagaca ......<.<<<............<<<<....>>>>......>>>........................>.. .......((((............(((((..)))))(..)..))).......................)... Cryo-EM structure of of the large subunit of Leishmania ribosome bound to paromomycin; rRNA zeta 6az3 7 163 2.5 RF00002 URS0000A76380_5661 29150609 0003735 0005840 5661 aacgugncgcgauggaugacuuggcuuccuauuucguugaagnacgcaguaaagugcgauaagugguaucaauuncagaaucauucaauuaccgaaucuuugaacgcaaacggcgcaugggagaagcucgugucauccccgugcaugccauacucngugucga .........................................<<<<<<.((.....>>>.....<<<<<......)).............>>>>.>...>>>....<<.....>><<<<<<<....<<....>>....>>>>>>>................... .........................................((((((.[[.....))).....(((((......]].............)))).)...)))....((.....))(((((((....((.().))....)))))))................... Cryo-EM structure of of the large subunit of Leishmania ribosome bound to paromomycin; rRNA 5.8S 6az3 8 118 2.5 RF00001 URS000047B859_5661 29150609 0003735 0005840 5661 gaguacgaccauacuugagugaaaacaccauaucccguccgauuugugaaguuaagcacucacaggcucaguuaguacugaggucagugaugacucgggaacccugagugccguacuc <<<<<<<......<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<......<<<<<..<<....>>.>>>>>.....>>>>>>..>>>>>>> (((((((.(....((((((((.....((((((...(....)...))))..))....)))))).))((((((......(((((..((....)).))))).....))))))).))))))) Cryo-EM structure of of the large subunit of Leishmania ribosome bound to paromomycin; rRNA 5S 6az4 A 32 2.98 URS0000CBFF2F_32630 29411978 32630 cugcugcugccgcuaaggaugaaagucuaugc ...........<<...<<<<....>>>>..>> ...........((...((((....))))..)) RNA hairpin complex with guanosine dinucleotide ligand G(5')ppp(5')G; RNA (32-MER) 6b19 C 19 4.5 RF00375 URS0000D56C30_11676 29695867 0000049 11676 guggcgcccgaacagggac ................... ................... Architecture of HIV-1 reverse transcriptase initiation complex core; RNA genome fragment 6b19 D 19 4.5 RF00005 URS0000D56C47_9606 29695867 0030533 0006412 9606 gucccuguucgggcgccac ................... ................... Architecture of HIV-1 reverse transcriptase initiation complex core; tRNA lysine3 6b4v A 1507 3.4 RF00177,RF01959,RF01960 URS0000A763A8_262724 29366636 0003735 0005840 262724 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgaggaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<<<<<<<<<.....>>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<.<..<<<<<<<.<..<<<......>>>.....>.>>>>>>>...>.......<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<.......<<<<<<...<<<<<<<....>>>>>>>..................>>>>>>..<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<...<<<.............>>>....>>>>>>.....<<<<<....>>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<......>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((((.((.........)).))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...(((.....))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.(((((((((.......((((((.....)))))).....)))))))..)))))))))...((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))...)))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((.((((((.....)))))).))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((.........(((....)))........(........)......)))))).((.((....(.((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((....(((..(.........)))).....)))))..(...((((....))).).....)..)))).....).).)))....)..))))....)))))))..[)).)))))))).(...(.(((((.....(((..((..((((....))))..))....))).....))))).)......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Antibiotic blasticidin S and E. coli release factor 1 bound to the 70S ribosome; 16S ribosomal RNA 6b4v B 2880 3.4 RF02540,RF02541,RF00002 URS0000A76375_262724 29366636 0003735 0005840 262724 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgccuuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgucuaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcucaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaaaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagcuccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagacgacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu 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(.(......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((........))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(.(...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..).))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((.(.((((..........)).)))..)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((............((................................................))........)))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....)))))))))....)))))))))..)))(......(....)........))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........(((......(.......((...(......)...)).....)...............)))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(..................(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))...)).) Antibiotic blasticidin S and E. coli release factor 1 bound to the 70S ribosome; 23S ribosomal RNA 6b4v C 120 3.4 RF00001 URS000080DFF2_262724 29366636 0003735 0005840 262724 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> .((((((((((....((((((((....(.(((((...(.....)...))))..).)...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Antibiotic blasticidin S and E. coli release factor 1 bound to the 70S ribosome; 5S ribosomal RNA 6b4v D 77 3.4 RF00005 URS000041AF00_83333 29366636 0030533 0006412 83333 cgcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca .<<<<<...<<<...........>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>.>>>>>..... .((((..............[.......(((((.......))))).......(((..]....)))....))))..... Antibiotic blasticidin S and E. coli release factor 1 bound to the 70S ribosome; tRNA 6b4v HA 11 3.4 29366636 32630 aaaauguaaaa ........... ........... Antibiotic blasticidin S and E. coli release factor 1 bound to the 70S ribosome; mRNA 6b4v IA 77 3.4 RF00005 URS000041AF00_83333 29366636 0030533 0006412 83333 cgcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca ..<<<<...<<<<.........>>>>.<<<<<.......>>>>>......<<<<.......>>>>..>>>>...... ..(((((..((((......[..)))).(((((.......)))))......((((..]....)))).)))))...... Antibiotic blasticidin S and E. coli release factor 1 bound to the 70S ribosome; tRNA 6b4v EB 1507 3.4 RF00177,RF01959,RF01960 URS0000A763A8_262724 29366636 0003735 0005840 262724 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgaggaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<<.....>>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<.<..<<<<<<<.<..<<<......>>>.....>.>>>>>>>...>.......<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<.......<<<<<<...<<<<<<<....>>>>>>>..................>>>>>>..<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<...<<<.............>>>....>>>>>>.....<<<<<....>>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<......>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((((.((.........)).))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...(((.....))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.(((((((((.......((((((.....)))))).....)))))))..)))))))))...((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))...)))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((.((((((.....)))))).))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((.........(((....)))........(........)......)))))).((.((....(.((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((....(((..(.........)))).....)))))..(...((((....))).).....)..)))).....).).)))....)..))))....)))))))..[)).)))))))).(...(.(((((.....(((..((..((((....))))..))....))).....))))).)......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Antibiotic blasticidin S and E. coli release factor 1 bound to the 70S ribosome; 16S ribosomal RNA 6b4v FB 2880 3.4 RF02540,RF02541,RF00002 URS0000A76375_262724 29366636 0003735 0005840 262724 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgccuuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgucuaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcucaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaaaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagcuccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagacgacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu 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(.(......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((........))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(.(...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..).))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((.(.((((..........)).)))..)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((............((................................................))........)))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....)))))))))....)))))))))..)))(......(....)........))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........(((......(.......((...(......)...)).....)...............)))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(..................(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))...)).) Antibiotic blasticidin S and E. coli release factor 1 bound to the 70S ribosome; 23S ribosomal RNA 6b4v GB 120 3.4 RF00001 URS000080DFF2_262724 29366636 0003735 0005840 262724 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> .((((((((((....((((((((....(.(((((...(.....)...))))..).)...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Antibiotic blasticidin S and E. coli release factor 1 bound to the 70S ribosome; 5S ribosomal RNA 6b4v HB 77 3.4 RF00005 URS000041AF00_83333 29366636 0030533 0006412 83333 cgcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca .<<<<<...<<<...........>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>.>>>>>..... .((((......................(((((.......))))).......(((.......)))....))))..... Antibiotic blasticidin S and E. coli release factor 1 bound to the 70S ribosome; tRNA 6b4v LC 11 3.4 29366636 32630 aaaauguaaaa ........... ........... Antibiotic blasticidin S and E. coli release factor 1 bound to the 70S ribosome; mRNA 6b4v MC 77 3.4 RF00005 URS000041AF00_83333 29366636 0030533 0006412 83333 cgcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca ..<<<<...<<<<.........>>>>.<<<<<.......>>>>>......<<<<.......>>>>..>>>>...... ..(((((..((((......[..)))).(((((.......)))))......((((..]....)))).)))))...... Antibiotic blasticidin S and E. coli release factor 1 bound to the 70S ribosome; tRNA 6bfb X 54 2.82 RF00050 URS000080DF4D_851 29412640 0010181 851 ggaucuucggggcagggugaaauucccgaccggugguauaguccacgaaagcuu ..............<<<.......>>>.....<<<<......>>>>........ ..............(((.......))).....((((......))))........ Crystal structure of a F. nucleatum FMN riboswitch bound to WG-3; RNA (54-MER) 6bfb Y 56 2.82 RF00050 URS000080E20B_851 29412640 0010181 851 gcuuugauuuggugaaauuccaaaaccgacaguagagucuggaugagagaagauuc .......<<<<<.......>>>>>.....<<<......>>>............... .......(((((.......))))).....(((......)))............... Crystal structure of a F. nucleatum FMN riboswitch bound to WG-3; RNA (56-MER) 6bg9 A 47 9.0 RF00175 URS0000CBFF35_9606 29398526 0019074 9606 ggcaggacucggcuugcugaagcgcgcacggcaagaggcgaggggcc ............................................... ............................................... HYBRID NMR/CRYO-EM STRUCTURE OF THE HIV-1 RNA DIMERIZATION SIGNAL; RNA dimerization signal 6bg9 B 47 9.0 RF00175 URS0000CBFF35_9606 29398526 0019074 9606 ggcaggacucggcuugcugaagcgcgcacggcaagaggcgaggggcc ............................................... ............................................... HYBRID NMR/CRYO-EM STRUCTURE OF THE HIV-1 RNA DIMERIZATION SIGNAL; RNA dimerization signal 6bgb A 16 1.65 URS0000CBFF3D_32630 29164215 32630 gcagncuuaagucugc ................ ................ Crystal Structure of the 16mer GCAGNCUUAAGUCUGC containing BrPh 7-triazolyl-8-aza-7-deazaadenosine; (5'-R(*GP*CP*AP*GP*(A7C)P*CP*UP*UP*AP*AP*GP*UP*CP*UP*GP*C)-3') 6bgb B 16 1.65 URS0000CBFF3D_32630 29164215 32630 gcagncuuaagucugc ................ ................ Crystal Structure of the 16mer GCAGNCUUAAGUCUGC containing BrPh 7-triazolyl-8-aza-7-deazaadenosine; (5'-R(*GP*CP*AP*GP*(A7C)P*CP*UP*UP*AP*AP*GP*UP*CP*UP*GP*C)-3') 6bgb C 16 1.65 URS0000CBFF3D_32630 29164215 32630 gcagncuuaagucugc ................ ................ Crystal Structure of the 16mer GCAGNCUUAAGUCUGC containing BrPh 7-triazolyl-8-aza-7-deazaadenosine; (5'-R(*GP*CP*AP*GP*(A7C)P*CP*UP*UP*AP*AP*GP*UP*CP*UP*GP*C)-3') 6bjg C 21 2.29 URS0000485571_7049 31021526,21819044 7049 ucgaaguauuccgcguacguu ..................... ..................... CIRV p19 mutant T111H in complex with siRNA; RNA (5'-R(P*UP*CP*GP*AP*AP*GP*UP*AP*UP*UP*CP*CP*GP*CP*GP*UP*AP*CP*GP*UP*U)-3') 6bjg D 21 2.29 URS000041F71C_7049 31021526,21819044 7049 cguacgcggaauacuucgauu ..................... ..................... CIRV p19 mutant T111H in complex with siRNA; RNA (5'-R(P*CP*GP*UP*AP*CP*GP*CP*GP*GP*AP*AP*UP*AP*CP*UP*UP*CP*GP*AP*UP*U)-3') 6bjh C 21 2.58 URS0000485571_7049 31021526,21819044 7049 ucgaaguauuccgcguacguu ..................... ..................... CIRV p19 mutant T111S in complex with siRNA; RNA (5'-R(P*UP*CP*GP*AP*AP*GP*UP*AP*UP*UP*CP*CP*GP*CP*GP*UP*AP*CP*GP*UP*U)-3') 6bjh D 21 2.58 URS000041F71C_7049 31021526,21819044 7049 cguacgcggaauacuucgauu ..................... ..................... CIRV p19 mutant T111S in complex with siRNA; RNA (5'-R(P*CP*GP*UP*AP*CP*GP*CP*GP*GP*AP*AP*UP*AP*CP*UP*UP*CP*GP*AP*UP*U)-3') 6bjv C 21 2.198 URS0000485571_7049 31021526,21819044 7049 ucgaaguauuccgcguacguu ..................... ..................... CIRV p19 protein in complex with siRNA; RNA (5'-R(P*UP*CP*GP*AP*AP*GP*UP*AP*UP*UP*CP*CP*GP*CP*GP*UP*AP*CP*GP*UP*U)-3') 6bjv D 21 2.198 URS000041F71C_7049 31021526,21819044 7049 cguacgcggaauacuucgauu ..................... ..................... CIRV p19 protein in complex with siRNA; RNA (5'-R(P*CP*GP*UP*AP*CP*GP*CP*GP*GP*AP*AP*UP*AP*CP*UP*UP*CP*GP*AP*UP*U)-3') 6bk8 2 135 3.3 RF00004 URS000023C730_4932 29146870 0045131 0000348 0005686 4932 gaaucucuuugccuuuuggcuuagaucaaguguaguaucuguucuguaacaacuguuguuacggacgggaagaggagacgucgcgacccucgcagucguucuugacuggucgcuugauguuucuucuucccguuc .............................................<<<<<<<...>>>>>>><<<<<<<<<<<.<<<<<<<<<<<<.<<.....<<<<....>>>>.>>>>>>..>>>>>>>>.>>>>>>>>>>> .............................................(((((((...)))))))(((((((((((.((((((((((((.((.....((((....)))).))))))..)))))))).))))))))))) S. cerevisiae spliceosomal post-catalytic P complex; U2 snRNA 6bk8 5 103 3.3 RF00020 URS000053F313_4932 29146870 0000244,0000353 0005682,0046540 4932 ggaggucaacaucaagaacugugggccuuugccuauagaacuuauaacgaacaugguucuugccuuuuaccagaaccauccggguguugucuccauauuuuuu <<<<<.<<<<<<<.....<<<<<<<<....>>>>>>>>..............<<<<<<<<...........>>>>>>>>...>>>>>>>>>>>>......... (((((.(((((((.....((.(((((....))))).)).........((...((((((((.(.......).)))))))).))))))))))))))......... S. cerevisiae spliceosomal post-catalytic P complex; U5 snRNA 6bk8 6 102 3.3 RF00026 URS00006184A9_4932 29146870 0030621 0000244,0000353 0005688,0046540 4932 guucgcgaaguaacccuucguggacauuuggucaauuugaaacaauacagagaugaucagcaguuccccugcauaaggaugaaccguuuuacaaagagauuu <<<<<<<<<<.....>>>>>>>>>>.....................................<<<..<<<.....>>>...>>>.................. ((((.(((((.....))))).)))).....................................(((.((((.....)))..)))).................. S. cerevisiae spliceosomal post-catalytic P complex; U6 snRNA 6bk8 e 34 3.3 URS0000CBFF54_4932 29146870 4932 uuuaauaaaaaaaguauauuuuuuuuuuuuuuau .................................. .................................. S. cerevisiae spliceosomal post-catalytic P complex; RNA (34-MER) 6bk8 i 59 3.3 URS0000CBFF2A_4932 29146870 4932 guauguauuuauuuuagaacuaguuacuaacauuuuuuuuuuaaaaaauaauuauauag ...................................<.<<<<.>>>>.>........... ..................................(..((((.))))...)......... S. cerevisiae spliceosomal post-catalytic P complex; RNA (59-MER) 6bmd A 24 3.0 URS0000CBFF4B_32630 29411978 32630 gaggugnngagcgcgaaagcgcuc ........<<<<<<....>>>>>> ........((((((....)))))) RNA hairpin containing GpppG-oligo to mimic intermediate formed by activated monomer and activated downstream helper; RNA (5'-R(P*GP*AP*GP*GP*UP*GP*(LCC)P*(LCC)P*GP*AP*GP*CP*GP*CP*GP*AP*AP*AP*GP*CP*GP*CP*UP*C)-3') 6bmd C 24 3.0 URS0000CBFF4B_32630 29411978 32630 gaggugnngagcgcgaaagcgcuc ........<<<<<<....>>>>>> ........((((((....)))))) RNA hairpin containing GpppG-oligo to mimic intermediate formed by activated monomer and activated downstream helper; RNA (5'-R(P*GP*AP*GP*GP*UP*GP*(LCC)P*(LCC)P*GP*AP*GP*CP*GP*CP*GP*AP*AP*AP*GP*CP*GP*CP*UP*C)-3') 6bmd E 24 3.0 URS0000CBFF4B_32630 29411978 32630 gaggugnngagcgcgaaagcgcuc ........<<<<<<....>>>>>> ........((((((....)))))) RNA hairpin containing GpppG-oligo to mimic intermediate formed by activated monomer and activated downstream helper; RNA (5'-R(P*GP*AP*GP*GP*UP*GP*(LCC)P*(LCC)P*GP*AP*GP*CP*GP*CP*GP*AP*AP*AP*GP*CP*GP*CP*UP*C)-3') 6boh A 1507 3.4 RF00177,RF01959,RF01960 URS0000A763A8_262724 29731232 0003735 0005840 262724 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgaggaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<<.....>>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<........<<........>>..........<<<<<<<.......<<<<.<<...<<<<<......>>>>>..................>>.>>>>..<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<.......>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>......>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>.........<.<<<<<<<........>>>>>>>>.........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>..... .....(((...[.[[[...))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.....)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((.(....).)))).....)))))....((((.(((((....))))).))))...(((.....))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))...((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))...)))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..((((...((((((((((......((........))........(....(..(..(...(.............((......)).......(..........).........)).((.(((...((.(((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..((...(.........).))...)))))))..(..(((((....))))).....)..)))).....).).))....)).)))))....)..)...).[)).)))))))).....((((((......(((..((..((((....))))..))....)))......))))))......(....(((((((........)))))))....)......)))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.... Antibiotic blasticidin S and E. coli release factor 1 (containing deletion 302-304) bound to the 70S ribosome; 16S ribosomal RNA 6boh B 2880 3.4 RF02540,RF02541,RF00002 URS0000A76375_262724 29731232 0003735 0005840 262724 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgccuuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgucuaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcucaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaaaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagcuccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagacgacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<........>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<..........>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<................................................>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>....>>>>>>>>>..>>><...<<<<<..>>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<..<<<<<<<...........<<<<...<<<..........<<........>>.......>>>.............>>>>..>>>>>>>..>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<<.....>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (........((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((........))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((...((...............))...)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((((((........(.(..)...................................(......)........)....))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....)))))))))....)))))))))..)))(....(((....)))......))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((...(((((((...........((((....((........(..(........)..).....))..............))))..)))))))...))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.((((.(........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))....(.......)......(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))......) Antibiotic blasticidin S and E. coli release factor 1 (containing deletion 302-304) bound to the 70S ribosome; 23S ribosomal RNA 6boh C 120 3.4 RF00001 URS000080DFF2_262724 29731232 0003735 0005840 262724 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<.....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>..>>>>>>>>>. .((((((((((....((((((.(....((((((....(.....)....)))..)))...).)))).))(((.......((((((((....)))))))).......))).)))))))))). Antibiotic blasticidin S and E. coli release factor 1 (containing deletion 302-304) bound to the 70S ribosome; 5S ribosomal RNA 6boh D 77 3.4 RF00005 URS000041AF00_83333 29731232 0030533 0006412 83333 cgcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca .<<<<<...<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>.>>>>>..... .((((......((.........))...(((((.......))))).......(((.......)))....))))..... Antibiotic blasticidin S and E. coli release factor 1 (containing deletion 302-304) bound to the 70S ribosome; tRNA 6boh HA 11 3.4 29731232 32630 aaaauguaaaa ........... ........... Antibiotic blasticidin S and E. coli release factor 1 (containing deletion 302-304) bound to the 70S ribosome; mRNA 6boh IA 77 3.4 RF00005 URS000041AF00_83333 29731232 0030533 0006412 83333 cgcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(......]........)))))))..... Antibiotic blasticidin S and E. coli release factor 1 (containing deletion 302-304) bound to the 70S ribosome; tRNA 6boh FB 1507 3.4 RF00177,RF01959,RF01960 URS0000A763A8_262724 29731232 0003735 0005840 262724 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgaggaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<<.....>>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<........<<........>>..........<<<<<<<.......<<<<.<<...<<<<<......>>>>>..................>>.>>>>..<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<.......>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>......>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>.........<.<<<<<<<........>>>>>>>>.........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>..... .....(((...[.[[[...))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.....)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((.(....).)))).....)))))....((((.(((((....))))).))))...(((.....))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))...((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))...)))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..((((...((((((((((......((........))........(....(..(..(...(.............((......)).......(..........).........)).((.(((...((.(((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..((...(.........).))...)))))))..(..(((((....))))).....)..)))).....).).))....)).)))))....)..)...).[)).)))))))).....((((((......(((..((..((((....))))..))....)))......))))))......(....(((((((........)))))))....)......)))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.... Antibiotic blasticidin S and E. coli release factor 1 (containing deletion 302-304) bound to the 70S ribosome; 16S ribosomal RNA 6boh GB 2880 3.4 RF02540,RF02541,RF00002 URS0000A76375_262724 29731232 0003735 0005840 262724 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgccuuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgucuaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcucaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaaaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagcuccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagacgacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu 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(........((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((........))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....((((.((((.[.....)))).))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((...((...............))...)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((((((........(.(..)...................................(......)........)....))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....)))))))))....)))))))))..)))(....(((....)))......))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((...(((((((...........((((....((........(..(........)..).....))..............))))..)))))))...))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.((((.(........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((.(((..(((((((((......))))))..))).(((((.....))))).....))).)..)...))).))....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))....(.......)......(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))......) Antibiotic blasticidin S and E. coli release factor 1 (containing deletion 302-304) bound to the 70S ribosome; 23S ribosomal RNA 6boh HB 120 3.4 RF00001 URS000080DFF2_262724 29731232 0003735 0005840 262724 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<.....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>..>>>>>>>>>. .((((((((((....((((((.(....((((((....(.....)....)))..)))...).)))).))(((.......((((((((....)))))))).......))).)))))))))). Antibiotic blasticidin S and E. coli release factor 1 (containing deletion 302-304) bound to the 70S ribosome; 5S ribosomal RNA 6boh IB 77 3.4 RF00005 URS000041AF00_83333 29731232 0030533 0006412 83333 cgcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca .<<<<<...<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>.>>>>>..... .((((......((.........))...(((((.......))))).......(((.......)))....))))..... Antibiotic blasticidin S and E. coli release factor 1 (containing deletion 302-304) bound to the 70S ribosome; tRNA 6boh MC 11 3.4 29731232 32630 aaaauguaaaa ........... ........... Antibiotic blasticidin S and E. coli release factor 1 (containing deletion 302-304) bound to the 70S ribosome; mRNA 6boh NC 77 3.4 RF00005 URS000041AF00_83333 29731232 0030533 0006412 83333 cgcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(......]........)))))))..... Antibiotic blasticidin S and E. coli release factor 1 (containing deletion 302-304) bound to the 70S ribosome; tRNA 6bok A 1507 3.55 RF00177,RF01959,RF01960 URS0000A763A8_262724 29731232 0003735 0005840 262724 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgaggaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<<.....>>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<.....<<<<<<<....>>>>>>>....................>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.....)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...(((.....))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))...((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))...)))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((.((......(((((....))))).....................)).)))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..((.......)))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.... E. coli release factor 1 (containing deletion 302-304) bound to the 70S ribosome; 16S ribosomal RNA 6bok B 2880 3.55 RF02540,RF02541,RF00002 URS0000A76375_262724 29731232 0003735 0005840 262724 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgccuuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgucuaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcucaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaaaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagcuccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagacgacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<........>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<..<.....................>..........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<..........<<<<......>>>>.......>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<<.....>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> .........((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((........))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((.(.((((..........)).)))..))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((((((........(((((...............................(...((......)).).)))))....))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((.{{{..).))))))(((...((((((((((((((((.((.....)))))))))....)))))))))..)))(...(((......))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((.(((((((........[..((((...............(............)...................]..))))..))))))).))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}}))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(...(.......)......(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)... E. coli release factor 1 (containing deletion 302-304) bound to the 70S ribosome; 23S ribosomal RNA 6bok C 120 3.55 RF00001 URS000080DFF2_262724 29731232 0003735 0005840 262724 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). E. coli release factor 1 (containing deletion 302-304) bound to the 70S ribosome; 5S ribosomal RNA 6bok D 77 3.55 RF00005 URS000041AF00_262724 29731232 0030533 0006412 262724 cgcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..(((.......[...))).(((((.......))))).....(.(.(..]....).).)))))))..... E. coli release factor 1 (containing deletion 302-304) bound to the 70S ribosome; 16S ribosomal RNA 6bok HA 11 3.55 29731232 32630 aaaauguaaaa ......<...> ........... E. coli release factor 1 (containing deletion 302-304) bound to the 70S ribosome; mRNA 6bok IA 77 3.55 RF00005 URS000041AF00_262724 29731232 0030533 0006412 262724 cgcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... E. coli release factor 1 (containing deletion 302-304) bound to the 70S ribosome; 16S ribosomal RNA 6bok DB 1507 3.55 RF00177,RF01959,RF01960 URS0000A763A8_262724 29731232 0003735 0005840 262724 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgaggaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<<.....>>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<.....<<<<<<<....>>>>>>>....................>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.....)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...(((.....))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))...((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))...)))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((.((......(((((....))))).....................)).)))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..((.......)))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.... E. coli release factor 1 (containing deletion 302-304) bound to the 70S ribosome; 16S ribosomal RNA 6bok EB 2880 3.55 RF02540,RF02541,RF00002 URS0000A76375_262724 29731232 0003735 0005840 262724 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgccuuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgucuaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcucaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaaaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagcuccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagacgacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<........>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<..<.....................>..........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<..........<<<<......>>>>.......>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<<..<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>>......>>>>>>>...<<<.....>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> .........((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((........))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((.(.((((..........)).)))..))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((((((........(((((...............................(...((......)).).)))))....))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((.{{{..).))))))(((...((((((((((((((((.((.....)))))))))....)))))))))..)))(...(((......))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((..((((((........[..((((...............(............)...................]..))))..))))))..))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}}))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(...(.......)......(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)... E. coli release factor 1 (containing deletion 302-304) bound to the 70S ribosome; 23S ribosomal RNA 6bok FB 120 3.55 RF00001 URS000080DFF2_262724 29731232 0003735 0005840 262724 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). E. coli release factor 1 (containing deletion 302-304) bound to the 70S ribosome; 5S ribosomal RNA 6bok GB 77 3.55 RF00005 URS000041AF00_262724 29731232 0030533 0006412 262724 cgcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..(((.......[...))).(((((.......))))).....(.(.(..]....).).)))))))..... E. coli release factor 1 (containing deletion 302-304) bound to the 70S ribosome; 16S ribosomal RNA 6bok KC 11 3.55 29731232 32630 aaaauguaaaa ......<...> ........... E. coli release factor 1 (containing deletion 302-304) bound to the 70S ribosome; mRNA 6bok LC 77 3.55 RF00005 URS000041AF00_262724 29731232 0030533 0006412 262724 cgcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... E. coli release factor 1 (containing deletion 302-304) bound to the 70S ribosome; 16S ribosomal RNA 6bu8 A 1539 3.5 RF00177,RF01959,RF01960 URS000080DDC0_83333 29247757 0003735 0005840 83333 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<<....>>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<....<<<<<<......>>>>>.>....>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>..<<.<<<<<.......<<<<<<<<<.......>>>>>>>>.>........>>>>>....>>.<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>..>>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<.....>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<...<<<.....>>>.>.....>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<....<<<....>>>....>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((...(....)...))).)))))..)))))......(((.......((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..(......))))))).)))))))..)).)))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....))))))).............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... 70S ribosome with S1 domains 1 and 2 (Class 1); 16S ribosomal RNA 6bu8 01 2903 3.5 RF02540,RF02541 URS0000BC4674_83333 29247757 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugucgaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<....<<<........>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<......<<...<<<.<<<<...<<<<<<<.....>>>>>.>>...>>>>.>>>..>>.......>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<.........>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<............>>>>>....>>>>>><<<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>.>>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>.>........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<..<<....>>...>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<..<<........<<<<<<<....>>>>>>>.....>>............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<.)))..>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<.........>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......((((((((((.((.(((...(((((......)))))[[......(((.....]])))...)))...)).))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...).)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((((((.......)))).))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(.(.........).)..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((..(......)..)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((...(((...(((....)))...)))...)))..(((((........)))))]](((((((((((((...((((....((((..(((..(((((((((((....{{{...))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((.(....).)))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((...((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((.(............((.(............(((..(......)..)))...................).))...).)).)))))))))))...((..((((((.....)))))).))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....((.((((.((..]]]]..)))))).)).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(..((((.....)))).(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). 70S ribosome with S1 domains 1 and 2 (Class 1); 23S ribosomal RNA 6bu8 02 120 3.5 RF00001 URS00008116C5_83333 29247757 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<......<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<........<<<<<<<...>>>>>>>........>>....>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((.(((((...))))).)).......))...)))))))))). 70S ribosome with S1 domains 1 and 2 (Class 1); 5S ribosomal RNA 6bu8 X 77 3.5 RF00005 URS000041AF00_83333 29247757 0030533 0006412 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(((((.......)))))))))))..... 70S ribosome with S1 domains 1 and 2 (Class 1); tRNAfMet 6bu8 V 18 3.5 29247757 83333 aggagguaaaaauguuca .................. .................. 70S ribosome with S1 domains 1 and 2 (Class 1); mRNA 6bu8 W 77 3.5 RF00005 URS000041AF00_83333 29247757 0030533 0006412 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(((((.......)))))))))))..... 70S ribosome with S1 domains 1 and 2 (Class 1); tRNAfMet 6bu8 Y 76 3.5 RF00005 URS00005AA258_83333 29247757 0030533 0006412 83333 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).(((((.......))))).....(((((..]....)))))))))))).... 70S ribosome with S1 domains 1 and 2 (Class 1); tRNAPhe 6bu9 B 24 6.8 URS0000CBFF1E_32644 29269422 32644 ggagguaguagguuguauaguagu ........................ ........................ Drosophila Dicer-2 bound to blunt dsRNA; RNA (5'-R(*GP*GP*AP*GP*GP*UP*AP*GP*UP*AP*GP*GP*UP*UP*GP*UP*AP*UP*AP*GP*UP*AP*GP*U)-3') 6bu9 C 17 6.8 URS0000CBFF4E_32644 29269422 32644 acuacuauacaaccuac ................. ................. Drosophila Dicer-2 bound to blunt dsRNA; RNA (5'-R(*AP*CP*UP*AP*CP*UP*AP*UP*AP*CP*AP*AP*CP*CP*UP*AP*C)-3') 6buw QA 1500 3.5 RF00177,RF01959,RF01960 URS0000E60B8D_300852 30476222 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggggucuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugaaaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<...>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<........>>..>>>>>>>>.<<<.<<<..<<<<<........<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>........>>>>..........>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((.(((((.))))).)))).)))))......(((......((((((((..((...(((((((.(((((....((((.(....).)))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((.(((((...))))).))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((.(..((((((((((......((........))..........(((((((......((((((((..(((((((....)))))))....(.(.....))...))))))))..((.(((...(((.((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((.......(((.....)))......))))))).....(((((....)))))........)))).....).)..))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))...........(((((((........))))))).......)..).))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)...((((((((....)))))))).}.. Thermus thermophilus 70S complex containing 16S G299A ram mutation and empty A site.; 16S rRNA 6buw QV 77 3.5 RF00005 URS000041AF00_562 30476222 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Thermus thermophilus 70S complex containing 16S G299A ram mutation and empty A site.; P-site tRNA fMet 6buw QX 12 3.5 30476222 562 agguaaaaaugu ............ ............ Thermus thermophilus 70S complex containing 16S G299A ram mutation and empty A site.; messenger RNA 6buw RA 2882 3.5 RF02540,RF02541,RF00002 URS00001698E8_300852 30476222 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu .<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<..>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<.........<<.<.<<...<<<<.......>>>>...>>.........<<......>>....>>>.....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<..<<..<<<.......<<<<<<<<..>>>>>>.>>...>>>............>>..>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<<..<<.......>>>..>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<<.....>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>. .((......((((((((((.....(((..((((((((((((......((((((.[[..[[[)))...].((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((((((((..).))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....(())...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((...((((((......)))).))...)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((........((...((...(((.........)))...)).........(........).....))....)))))))))).))..........]]].)....))))))))))...)))))))(((((((.......)))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(....(((....)))......))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((.(((..(((.(..........(.((..(((.......(..((((....))))...)...)))............))..)).)))..))).)))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....((((((..((..]]]]..)).)))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(....(.....).......(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))...))). Thermus thermophilus 70S complex containing 16S G299A ram mutation and empty A site.; 23S rRNA 6buw RB 120 3.5 RF00001 URS00005F2F4B_300852 30476222 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>>> ((((((((((.....((((((.(....(((((((...(.....)...))))..)))...).)))).))(((.......((.(((((....))))).)).......)))..)))))))))) Thermus thermophilus 70S complex containing 16S G299A ram mutation and empty A site.; 5S rRNA 6buw XA 1500 3.5 RF00177,RF01959,RF01960 URS0000E60B8D_300852 30476222 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggggacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugaaaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<...>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>....<<<<.<<<<<....>>>>>.>>>>...<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<....<<<......>>>.......>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<<....>>>>..>>>>>>>>.<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(.(..((...((((((.(.).))))))...)).))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((.(..(..(((((........)))))....((......))...)..).)))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.((((.((.......(((.....)))......)).)))).....(.(.........))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Thermus thermophilus 70S complex containing 16S G299A ram mutation and empty A site.; 16S rRNA 6buw XV 77 3.5 RF00005 URS000041AF00_562 30476222 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Thermus thermophilus 70S complex containing 16S G299A ram mutation and empty A site.; P-site tRNA fMet 6buw XX 11 3.5 30476222 562 gguaaaaaugu ........... ........... Thermus thermophilus 70S complex containing 16S G299A ram mutation and empty A site.; messenger RNA 6buw YA 2883 3.5 RF02540,RF02541,RF00002 URS00001698E8_300852 30476222 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<..>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<..>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<<..>>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<....<......<<<<<<<......>>>>>>>...>..............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<..<<<<<<<...<<.......>>...>>>>>>>...>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<<.....>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((..)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((((((((..).))))))))....(.(((((((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....(())...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((...((..((......))...))...)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......((((...(....(...........)....)......(...((......)).)..))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(....(((....)))......))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((((..((.............(..(....(......((.((..(....)..)).))...)..............)..)....))..)))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....((((((..((..]]]]..)).)))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(...((.....).).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Thermus thermophilus 70S complex containing 16S G299A ram mutation and empty A site.; 23S rRNA 6buw YB 120 3.5 RF00001 URS00005F2F4B_300852 30476222 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> .((((((.(((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).))).)))))). Thermus thermophilus 70S complex containing 16S G299A ram mutation and empty A site.; 5S rRNA 6by1 AA 1540 3.94 RF00177,RF01959,RF01960 URS0000E60B85_83333 30552154 0003735 0005840 83333 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<....<<<<<<<<......>>>>>>.>>..>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<....<.<<<<......>>>>..>....>>.>.....<<<....>>>.....<<<<<..<<....>>>>>>>..>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<.<<.........>>>>>>.<<<.<..>.>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<.......<<<....>>>......>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<.<......<<<<<<.....>>>>>>....>.>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<..<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<........<<<<<..<<<<.<<....>>.>>>>...<<<..>>>..>>>>>....<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<.<...<<...<<<.....>>>.>..>..>.>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>.....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ ........(((...[.[[[...))).((((.(((((..(((((((((....(((.(((..(.(..(..((...((.((((........))))..)).))...)).)......(((......((((.(...((...(((.(.....((......(((((....))))).......)).......(((....))).....((..(..((....)))..).)...).)))..))..).))))(((....(((..((((((.(.......).)))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(..((....))...))))).)).))))))..((((........((....)).......))))...(.(((((..((....((((((((.......)))))))).....)..).)))))....)..((((([[[...((((......((.]]]))........)))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((...(......((((((.....))))))....)...))))..)))))))))..(((((((((...((((((.(....(((((((...((........))......)))))))....).......((....))..))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((.(((.((.(.....).)).))).)))...((..]])).....)))))))))).(((......(.((....)).)....)))...]]].]((((...((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((..(..(((...(....)...)))....(....)...)..)).))).((.(((...((((((.(....((((((.((....))....((........))...)))))).....(((..(((...(...((..(((.....)))))....)...)))..(...((((.....))))......)...))).....).).)))...)).)))))....)))))))...)).)))))))).(...((((((......(((..((...(((....)))...))....)))......))))))...........(((((((........))))))).......)..))))).....(((((((.........)))))))......))...))))))..)).))..(.(..((.(.((((.(((..(.(.((.(((((....(((.(..((((..((....)).)))).).)))...))))).)).).)..))).))))..).))...)..)..(((((.(((....))).)))))}........... E. coli pH03H9 complex; 16S ribosomal RNA 6by1 CA 2867 3.94 RF02540,RF02541 URS00004B0F34_83333 30552154 0003735 0005840 83333 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<<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<....<<<<<<.....>>>>>.>....>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<.........>>>...>>........<..........>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><<<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>.>>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>.>..>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<.......>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<....<<..>>.....>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.......<<<<<..<<....>>...>>>>>.......>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<..<<<<.<<<<<<...<<..<<..>>...>>....>>>>>>.>>>>..>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((.......(((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).((((((((...........)))))))).))...((((((.....(...[..)......))))).).........((....))....((((.....((.]...))....))))....((((.((((......(((..(((((.((.(((...(((.(......).)))[[(...).(((.....]])))...)))...)).)))))..)))...))))...).....(((.(((..[......))).))).......((.((].[[[[)).))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))......(.((.(..((((.(....).))))..).))...(.(........).).((((((....((((.((((((((..(((...((.....))...)))...((....))..(((.......))).....)))))))).))))..((.(...((((((.....(((((((.((.((((....(((((......)))))....)[)))...(((.(((((........))))))))..).).))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))..(.(((((..((((((((((.....(((...(((.((((....((.(((.....))).).)....)))).)))..)).).....)))))).)))..)))))).).....((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.((...(((.........)))...)).....(..(..........)).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((.((((....)))).))))....))))))(.(((((...(((......(((((((......)))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(.(...(((....)))...).)..))))..(((((........)))))]]((((((((((.((.....((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(...((((....))))....))))))...)))...))))(..).....)).....)).....)))))))))).))).))).....((......)).)))).(((.......)))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((......((...(((((..)]))))...))....))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..((((((...(((........((.((..((....))...)).))........))).))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).[..(((((......].)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((((..(.(.((((.((((((...((...(..)....))....)))))).)))).).)..))))))...((..((((((.....)))))).))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))).)..((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...(.........)...))))))...)))).).)......(.((.((((((..((.(((.((......)).)))...)).(((((.....))))).....)))))..)...))..).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...(.((...((((.((((((}}}.))))))...))))...)).).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). E. coli pH03H9 complex; 23S ribosomal RNA 6by1 CB 118 3.94 RF00001 URS0000366A67_83333 30552154 0003735 0005840 83333 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<...<...<<<<<<<<...>>>>>>>>.....>.>>...>>>>>>>>>. (((((((.(.....((.(((.(....(((((((...(.....)...))))..)))...).)))..)).((.......((((((((...)))))))).......))...).))))))). E. coli pH03H9 complex; 5S ribosomal RNA 6by1 AV 76 3.94 RF00005 URS000009F4BF_83333 30552154 0030533 0006412 83333 gggugauuagcucagcugggagagcaccucccuuacaaggagggggucggcgguucgaucccgucaucacccacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).(((((.......))))).....(.(((..]....))).)))))))).... E. coli pH03H9 complex; Valine-specific transfer RNA 6by1 AY 76 3.94 RF00005 URS000009F4BF_83333 30552154 0030533 0006412 83333 gggugauuagcucagcugggagagcaccucccuuacaaggagggggucggcgguucgaucccgucaucacccacca .<<<.<<..<<............>>.<.<<<.......>>>.>.....<<<<<.......>>>>>>>.>>>..... .((...(..((.(........).)).(..((.......))..).......(((.......)))..)...).).... E. coli pH03H9 complex; Valine-specific transfer RNA 6by1 AX 30 3.94 30552154 562 aaggaaauaaaaaugguaguaguagauaac .............................. .............................. E. coli pH03H9 complex; Messenger RNA 6by1 AW 76 3.94 RF00005 URS000009F4BF_83333 30552154 0030533 0006412 83333 gggugauuagcucagcugggagagcaccucccuuacaaggagggggucggcgguucgaucccgucaucacccacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).(((((.......))))).....(.(((..]....))).)))))))).... E. coli pH03H9 complex; Valine-specific transfer RNA 6by1 BA 1541 3.94 RF00177,RF01959,RF01960 URS0000E60B85_83333 30552154 0003735 0005840 83333 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccuu ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<.<<<<<<....>>>>.>>.>>>.>..>>>>>......<<..<....<<<<<<<..<<...<<<<<<<.<.<<..<.<<<<<<......>>>>>.>...>>>.>.....<<<....>>>....<<<.<<<.<<<..>>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>>>>.<<<<.<<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<..<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<..<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<.....>>>>>.........>>>.......>.>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<.<..<<...<<<....>>>...>>.....>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>.....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>...>>>>>>>>>>>>..>>.>>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............. ........((((..[.[[[..)))).(((..(((((..(((((((((....(((.(((..(((...(.((..((((..((((....))))..).)))))..).)))......(((.......((((((..((...(.(.(((...((.....(.((((....)))).)......)).......(((....))).....((..(..((....)))..))..))).).)..)).)))))).(((....((...((((((.(.......).)))))).))......)))..((((((((....))))...))))))).((((.(...........))))).((((....))))...)))))).).....(.(((...(.(((....)))..))))).)).))))))..((((......((((....)))).....))))...(.(((((..((...((((.((((.......)))).))).)...)..).)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..))))).)))..........((([[...(.((((....((.(.((((..((.((((((.......((((((.....)))))).....))))))...)).)))).)..(((((((((....(((((.(....(((((.(...((........))......).)))))....).......((....))..)))))...)))).))))..)))....))))....((((((...((...((((.........))))...))))))))......{...(((.((..(((.(.((.(((.....))).)).).)))...((..]])).....)).))))))).(((......(.((....)).)....)))...]]].]((((..(((((((.((..(((((..((((.(((((......((........))..........(((((((..(...(((((((...((.(((....))).)).....(....)...))))).)))..(.(((....(((((.(....((((((.((....))....(((......)))...)))))).....(((...((((((....(..(((.....)))).....))))))...(..(((((.....))))).....)...))).....).).)))...)..)))).....)))))))...)).))).)))).(...(.((((......(....((...(((....)))...))......)......)))).)......(.....((((((........)))))).....)..)..))))).....(.((.((.........)).)).)......))...))))))).)).))..(.(..((.(.((((..((..((((((((((((....(((.((.((.....(....)....)))).)))...))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}............ E. coli pH03H9 complex; 16S ribosomal RNA 6by1 DA 2869 3.94 RF02540,RF02541 URS00004B0F34_83333 30552154 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuuggcuuugaaguguggacgccagucugcauggagccgaaaauacauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<........<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>.>....>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<<<<..>>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<.........>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><<<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>.>>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<.<<<<<<<<.<.......>>>>>>>>>...>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<....<<..>>.....>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.......<<<.<..<<....>>...>.>>>.......>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<....<<<......<<<<<<<<....>>>>>>>>...>>>...........>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((.......(((((((((.....(((..((((((((.((((......((((((.[..[[[.))).....((.(((...(((]]]..].))).......))).))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...((((......((.]...)).....))))...((((.((((..........((((((.((.(((...(((((......)))))[[(...).(((.....]])))...)))...)).)))))).......))))...).....(.(((((..[......))))).).......((.((].[[[[)).))..)))......))..)))))).))...............((....))....))......(..((((.....))))............)).....)))))))))......(.((((..((((.(....).))))..)))).[.(.(........).).((((((....((((.((((((((..(((...((.....))...)))...((....))..(.((.....)).).....)))))))).))))..((.(...((((((.....(((((.(.((.((((...((((.(......).))))...)[)))...(((.(((((........))))))))..).).).))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((.(((((..(((.((((((.....(((...(((.((((...((..(((.....)))...))...)))).)))..)).).....))))))..))..)))))).).)...((((.(((.(......).))).))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(..((..(.(.....{..((.(.(((..((...........))..)))........(((......)))..).))....).)..))..).))...........]]].)...))))))))))...)))))))((.((((((....)))))).))....))))))(((((((....((.......((.((((....)))).))....))...))))).)).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((.(((((((((...(.((....((((..(((..(((((.((((((...{{{.).))))).(....(((....(..(.((((((.(.......))))))).)....)...[))).....)(..(((((....)))))...))))))...)))...))))(..).....)).)...))....))))))).))).))).))).....((......)).)))).(((.......)))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((.(((......(....(.(((..)])).).....)...))).))(...).......(((((.(((.].((.........))....((((((.....(((....))).......))))))..}((((.(((..(((((((..(..........((.((..((....))...).)))..........))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).).))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((...(((..(((.(((((.((((((..(.(...(((.......((.((((....)))).))....)))..........).)..))))))...((...(((((.....)))))..))....))))).)))...)))...((.......[.))((((((..........]))))))([((.....(((((...(((((.........))))).....((][.[[[))....))))).....((((..((((..{.))))..)))).(((....))).))]]].].....((((((..((..]]]]..)).)))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......(.((.((((((..((.((((((......))))))...)).(((((.....))))).....)))))..)...))..).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...((((.((((((}}}.))))))...))))...)))).)))))....((....((((.....}.......))))....))..))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....(((.((((..(.....(((((....)))))....)...))))..))).....))..).))))))))). E. coli pH03H9 complex; 23S ribosomal RNA 6by1 DB 118 3.94 RF00001 URS0000366A67_83333 30552154 0003735 0005840 83333 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. ((((....(.....((.(((((....((((((....(.....)....)))..)))...)))))..)).((.......((((((((...)))))))).......))...)....)))). E. coli pH03H9 complex; 5S ribosomal RNA 6by1 BV 76 3.94 RF00005 URS000009F4BF_83333 30552154 0030533 0006412 83333 gggugauuagcucagcugggagagcaccucccuuacaaggagggggucggcgguucgaucccgucaucacccacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).(((((.......))))).....(.(((..]....))).)))))))).... E. coli pH03H9 complex; Valine-specific transfer RNA 6by1 BX 30 3.94 30552154 562 aaggaaauaaaaaugguaguaguagauaac .............................. .............................. E. coli pH03H9 complex; Messenger RNA 6by1 BW 76 3.94 RF00005 URS000009F4BF_83333 30552154 0030533 0006412 83333 gggugauuagcucagcugggagagcaccucccuuacaaggagggggucggcgguucgaucccgucaucacccacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).(((((.......))))).....(.(((..]....))).)))))))).... E. coli pH03H9 complex; Valine-specific transfer RNA 6bz6 QA 1498 3.18 RF00177,RF01959,RF01960 URS0000E60B7E_300852 30476222 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggggucuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccugugaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<...>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<....>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<.<<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>.....<......>....>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((.).)))...)))))).).....(.(((...(.(((....)))..))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((.(((((((...))))))).))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(.((((((..(((((((....))))))).....((....))....)))))).)).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.((((((....(...(((.....))).).....))))))......((((....)))).........)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((..........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Thermus thermophilus 70S complex containing 16S G347U ram mutation and empty A site; 16S rRNA 6bz6 QV 77 3.18 RF00005 URS000041AF00_562 30476222 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Thermus thermophilus 70S complex containing 16S G347U ram mutation and empty A site; tRNA fMet 6bz6 QX 12 3.18 30476222 562 gguaaaaauguu ............ ............ Thermus thermophilus 70S complex containing 16S G347U ram mutation and empty A site; messenger RNA 6bz6 RA 2882 3.18 RF02540,RF02541,RF00002 URS00001698E8_300852 30476222 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu .<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>....<<<<<.....<......>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<..>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<....<<<<<......>>>>.>....>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<<........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>.>>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<...<.......<<<<<<<<....>>>>>>>>....>.............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<<..<<.......>>>..>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<<.....>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>. .((......((((((((((.....(((..((((((((((((......((((((.[[..[[[)))...].((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....(())...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((...(((((........))).))...))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......(((.(..(...(((.........)))...)..........((......))...).)))...)))))))))).))..........]]].)....))))))))))...)))))))(((((((.......)))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(....(((....)))......))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((((.((((.(...........(((..((.......((((((((....))))))))....))............)))..).)))).)))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....((((((..((..]]]]..)).)))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(....(.....).......(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))...))). Thermus thermophilus 70S complex containing 16S G347U ram mutation and empty A site; 23S rRNA 6bz6 RB 120 3.18 RF00001 URS00005F2F4B_300852 30476222 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).)))))))))). Thermus thermophilus 70S complex containing 16S G347U ram mutation and empty A site; 5S rRNA 6bz6 XA 1500 3.18 RF00177,RF01959,RF01960 URS0000E60B7E_300852 30476222 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggggacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgugaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<...>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<......>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<......>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((.(.).)))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((...).)))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((.(.(..(((((((....)))))))...((.(.....)))..)..)))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((.......(((.....)))......))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Thermus thermophilus 70S complex containing 16S G347U ram mutation and empty A site; 16S rRNA 6bz6 XV 77 3.18 RF00005 URS000041AF00_562 30476222 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Thermus thermophilus 70S complex containing 16S G347U ram mutation and empty A site; tRNA fMet 6bz6 XX 11 3.18 30476222 562 gguaaaaaugu ........... ........... Thermus thermophilus 70S complex containing 16S G347U ram mutation and empty A site; messenger RNA 6bz6 YA 2883 3.18 RF02540,RF02541,RF00002 URS00001698E8_300852 30476222 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<..>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<..>...>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<....<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.....>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<<..>>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<...<<......<<<<<<<<....>>>>>>>>...>>.............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<.]]]].>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<<.....>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((..)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....(())...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((...((((((......)))).))...)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......((((...((...((.........))...))......(...((......)).)..))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((.{{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((((.((((.(.........(((.(...(.......((((((((....))))))))....).............).)))).)))).)))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}}))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(....(.....).......(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Thermus thermophilus 70S complex containing 16S G347U ram mutation and empty A site; 23S rRNA 6bz6 YB 120 3.18 RF00001 URS00005F2F4B_300852 30476222 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).)))))))))). Thermus thermophilus 70S complex containing 16S G347U ram mutation and empty A site; 5S rRNA 6bz7 QA 1500 3.68 RF00177,RF01959,RF01960 URS0000E60B8D_300852 30476222 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggggucuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugaaaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<...<..<<<.<<<..<<<..<<.<<<<<<<<<...>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>...>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>..>>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<......>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((.(.((((((((((......((((((.....))))))....))))))))..))).)))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(.((((((..(((((((....)))))))....(((....)))...)))))).)).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((.......(((.....)))......))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Thermus thermophilus 70S containing 16S G299A point mutation and near-cognate ASL Leucine in A site.; 16S rRNA 6bz7 QV 77 3.68 RF00005 URS000041AF00_562 30476222 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Thermus thermophilus 70S containing 16S G299A point mutation and near-cognate ASL Leucine in A site.; tRNA fMet 6bz7 QW 76 3.68 RF00005 URS000041AF00_562 30476222 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacc .<<<<<<..<<<...........>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>.... .((((((..((((.........)))).(((((.......))))).....(.(((.......))).))))))).... Thermus thermophilus 70S containing 16S G299A point mutation and near-cognate ASL Leucine in A site.; tRNA fMet 6bz7 QY 17 3.68 URS0000E60BBE_562 30476222 562 agggauuuaaaaucccu <<<<<<.....>>>>>> (((((.......))))) Thermus thermophilus 70S containing 16S G299A point mutation and near-cognate ASL Leucine in A site.; ASL Leu 6bz7 RA 2882 3.68 RF02540,RF02541,RF00002 URS00001698E8_300852 30476222 0003735 0005840 300852 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Thermus thermophilus 70S containing 16S G299A point mutation and near-cognate ASL Leucine in A site.; 23S rRNA 6bz7 RB 120 3.68 RF00001 URS00005F2F4B_300852 30476222 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>>> .((((((((((....((((((((....(((.(((...(.....)...)))...)))...)))))).))(((.......((.(((((....))))).)).......))).)))))))))). Thermus thermophilus 70S containing 16S G299A point mutation and near-cognate ASL Leucine in A site.; 5S rRNA 6bz7 XA 1500 3.68 RF00177,RF01959,RF01960 URS0000E60B8D_300852 30476222 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggggacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugaaaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<...>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<<....>>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(.(..((.((((((((.(.).)))))))).)).))......(((......((((((((..((...(((((((.(((((....((((.(....).)))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((.(((((......((........))..........(((((((..(...(((((.((..(((.(((....))).)))....(((....)))...)).)))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((.......(((.....)))......))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).))).)))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Thermus thermophilus 70S containing 16S G299A point mutation and near-cognate ASL Leucine in A site.; 16S rRNA 6bz7 XV 77 3.68 RF00005 URS000041AF00_562 30476222 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Thermus thermophilus 70S containing 16S G299A point mutation and near-cognate ASL Leucine in A site.; tRNA fMet 6bz7 XW 76 3.68 RF00005 URS000041AF00_562 30476222 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacc .<<<<<<..<<<...........>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>.... .((((((..((((.........)))).(((((.......))))).....(.(((.......))).))))))).... Thermus thermophilus 70S containing 16S G299A point mutation and near-cognate ASL Leucine in A site.; tRNA fMet 6bz7 XX 10 3.68 30476222 562 aaaauguuca .......... .......... Thermus thermophilus 70S containing 16S G299A point mutation and near-cognate ASL Leucine in A site.; messenger RNA 6bz7 XY 17 3.68 URS0000E60BBE_562 30476222 562 agggauuuaaaaucccu <<<<<<.....>>>>>> (((((.......))))) Thermus thermophilus 70S containing 16S G299A point mutation and near-cognate ASL Leucine in A site.; ASL Leu 6bz7 YA 2883 3.68 RF02540,RF02541,RF00002 URS00001698E8_300852 30476222 0003735 0005840 300852 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Thermus thermophilus 70S containing 16S G299A point mutation and near-cognate ASL Leucine in A site.; 23S rRNA 6bz7 YB 120 3.68 RF00001 URS00005F2F4B_300852 30476222 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> .((((((((((....((((((((....(((.(((...(.....)...)))...)))...)))))).))(((.......((.(((((....))))).)).......))).)))))))))). Thermus thermophilus 70S containing 16S G299A point mutation and near-cognate ASL Leucine in A site.; 5S rRNA 6bz8 QA 1500 3.74 RF00177,RF01959,RF01960 URS0000E60B7E_300852 30476222 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggggucuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgugaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<...>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<......>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<........>>..>>>>>>>>.<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((.(....).))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((...).)))...)))))).).....(.(((...(.(((....)))..))))).)).))))))..((((......((((....)))).....))))....(((((...(....(((.......))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((((..(((((((....))))))).....(.......)...))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.((((((.........((.....))........))))))......((((....)))).........)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((..........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Thermus thermophilus 70S containing 16S G347U point mutation and near-cognate ASL Leucine in A site; 16S rRNA 6bz8 QV 77 3.74 RF00005 URS000041AF00_562 30476222 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(.(((..]....))).)))))))..... Thermus thermophilus 70S containing 16S G347U point mutation and near-cognate ASL Leucine in A site; tRNA fMet 6bz8 QW 77 3.74 RF00005 URS000041AF00_562 30476222 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<...........>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(.(((.......))).)))))))..... Thermus thermophilus 70S containing 16S G347U point mutation and near-cognate ASL Leucine in A site; tRNA fMet 6bz8 QY 17 3.74 URS0000E60BBC_562 30476222 562 ggggauuuaaaaucccc <<<<<<.....>>>>>> .((((.......)))). Thermus thermophilus 70S containing 16S G347U point mutation and near-cognate ASL Leucine in A site; ASL Leu 6bz8 RA 2882 3.74 RF02540,RF02541,RF00002 URS00001698E8_300852 30476222 0003735 0005840 300852 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Thermus thermophilus 70S containing 16S G347U point mutation and near-cognate ASL Leucine in A site; 23S rRNA 6bz8 RB 120 3.74 RF00001 URS00005F2F4B_300852 30476222 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> .((((((.((.....((((((.(....(((((((...(.....)...))))..)))...).)))).))(((.......((.(((((....))))).)).......)))..)).)))))). Thermus thermophilus 70S containing 16S G347U point mutation and near-cognate ASL Leucine in A site; 5S rRNA 6bz8 XA 1500 3.74 RF00177,RF01959,RF01960 URS0000E60B7E_300852 30476222 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggggacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgugaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<...>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<......>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<......>>>..>>>>>>>>.<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((.(.).)))))))).)))))......(((......((((((((..((...(((((((.(((((.....(((((....)))))......)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((...).)))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((.(......))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((.(.((((((((((......((((((.....))))))....))))))))..))).)))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((.(..((((((((((......((........))..........(((((((..(...((((((((..(((.(((....))).)))...((.(.....)))..))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((.......(((.....)))......))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..).))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Thermus thermophilus 70S containing 16S G347U point mutation and near-cognate ASL Leucine in A site; 16S rRNA 6bz8 XV 77 3.74 RF00005 URS000041AF00_562 30476222 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(.(((..]....))).)))))))..... Thermus thermophilus 70S containing 16S G347U point mutation and near-cognate ASL Leucine in A site; tRNA fMet 6bz8 XW 77 3.74 RF00005 URS000041AF00_562 30476222 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<...........>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(.(((.......))).)))))))..... Thermus thermophilus 70S containing 16S G347U point mutation and near-cognate ASL Leucine in A site; tRNA fMet 6bz8 XX 11 3.74 30476222 562 aaaauguucca ........... ........... Thermus thermophilus 70S containing 16S G347U point mutation and near-cognate ASL Leucine in A site; messenger RNA 6bz8 XY 17 3.74 URS0000E60BBC_562 30476222 562 ggggauuuaaaaucccc <<<<<<.....>>>>>> .((((.......)))). Thermus thermophilus 70S containing 16S G347U point mutation and near-cognate ASL Leucine in A site; ASL Leu 6bz8 YA 2883 3.74 RF02540,RF02541,RF00002 URS00001698E8_300852 30476222 0003735 0005840 300852 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(((.......(((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((..)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...(((((((.......)))))))....{.(((((((((......(...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)..)))))).))))....(((((((((.[.....)))))))))....}.(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))......(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....(..)...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((.(((...(((...((((((((...((.((........))..))...))))))))..)).)...))).)))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((........((((......((((.......))))..........(...((......)).).))))....)))))))))).))..........]]].)....))))))))))...)))))))(.((((((.....)))))).)....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((.(((((((.((.....)))))))))......))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((.((.((((((.(.........(((((..(((......((((((((....))))))))...)))............)))))).)))))).)).))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...((.((((.(.(((((.........)))))...).((][.[[[))....)))).))...((((..(((...{..)))..)))).(((....))).))]]].].....((((((..((..]]]]..)).)))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((.(((.}}.))).))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(..(((.....))).....(((((((((.......)))))....(((.((((..((....(((((....)))))...))...))))..)))...))))...)))) Thermus thermophilus 70S containing 16S G347U point mutation and near-cognate ASL Leucine in A site; 23S rRNA 6bz8 YB 120 3.74 RF00001 URS00005F2F4B_300852 30476222 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> .((((((.((.....((((((.(....(((((((...(.....)...))))..)))...).)))).))(((.......((.(((((....))))).)).......)))..)).)))))). Thermus thermophilus 70S containing 16S G347U point mutation and near-cognate ASL Leucine in A site; 5S rRNA 6c0f 1 1357 3.7 RF02540,RF02543 URS0000D56C49_1247190 29512650 0003735 0005840 1247190 guuugaccucaaaucagguaggaguacccgcugaaaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuuugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaugguguuuugugcccucugcuccuuguggguaggggaaucucgcauuucacugggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccugguuccugccgaagaacguagaguuaaggugccggaauacacgcucaucagaggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauugauagaauaaucuagcgaaaccaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugugcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugaucuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaauggcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuug ..........................<<<<<<....>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..<<<..<........<<.<<<<<<...>>>>>>.>>........>....<<<<<<<.<<<.<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>>..>>>>>>>.....>>>>>>>>>>........<<<<<<<...>>>>>>>.....<<<<<<......>>>>>>..>>>..................................<<....>>...............<<<......>>>..................................<<<<<.<<<<<<.....<<<<...<<<<.<<<<<<<<<.....>>>>>>>>>.....>>>>...>>>>..<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>>..>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>.>>>>>....<<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<......>...>>>>.>>.>>....>>>>>>.>>>>>>..<<..>>..<<<<<<.......<<<<<<<..<<<<(((.....<<<<<<.....<<.))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>>..<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<........<<<<....>>>>.>....>>....<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<<<<.<<<<<.<..>...>>>>>>>>>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>.<<<<<<.<.........<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>...........>.>>>>>>.<<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<.<..<<<<<......>>>>>..>>>>>...>>>....>>>>.>>>>>..>>>>>> ..........................(((((......)))).).........((....))...((((......((.....)).....))))...((((.........(((.((.(((...))).)).))....)........((.((((.(((((((.((((((((.(((...({((((......)))))[[(...).(((....}]])))....))).))))..)))).)))....)))))))).))...)....(((((((...))))))).....((((((......))))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....((((...((((.((.((((((.....)))))).)).....))))...))))..((((((((((((((.((((((((.......(((((((......((((((....)))))).......))))))).....))))).))).))))))........(((....)))....))))))))....)))))).)))))....((((((....((((((.((((((..(((...(((.......)))...)))...(.(((..(((((....)))))...))).).(((((.((....(....)....))..))).))....)))))).))))))..((..))..((((((.......(((((((...((([[[...(.((((((......(.]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.......((((....))))))....)).....((((((..(((((..(((((......(....).....)))))..(((((...((((((..(((((.(..)...))))).))))))..))))).((((...((((.............))))...)))))))))....))))))..((((((.(.........((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).))))))...........).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))). Yeast nucleolar pre-60S ribosomal subunit (state 2); Saccharomyces cerevisiae S288c 35S pre-ribosomal RNA miscRNA 6c0f 2 158 3.7 RF00002 URS00001BF64E_1247190 29512650 0003735 0005840 1247190 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<<((....>>>>.....<.<<<<.....))............>.>>>..>...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Yeast nucleolar pre-60S ribosomal subunit (state 2); 5.8S rRNA 6c0f 6 87 3.7 URS000013305B_1247190 29512650 1247190 ccuucucaaacauucuguuugguagugagugauacucuuuggaguuaacuugaaauugcuggccuuuaggcgaacaauguucuuaaa ......<<<<<.....>>>>>.....<<<<...<<<<....>>>>..>>>>..........<<<<..>>>>................ ......(((((.....)))))....(((((...((((....))))..))))..).......((((..))))................ Yeast nucleolar pre-60S ribosomal subunit (state 2); ITS2 6c4h A 636 3.1 RF02540,RF02541 URS0000B21DEA_562 29403017 0003735 0005840 562 gaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaacuauuuagcacacggcgggugcuaacguccgucgaagaugaaggaacuaggcaaaauggugauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggcgguaaacggccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugcc ...<<<.<<<<<........>>>>>>>>................<<<.....>>>....................<<<<<<......>>>>>>.........<<.........................<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<.>>>>..>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>...........................<<<<<........>>>>>.......<<<.<<<.<<......<<<<.<<<<<<..<<<<<.<<<.<<<.>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>.........>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>>>> ...(((.(((.(........)).)))))..............(.(((.....)))...)...............((((((........))))))........((..(....(.................(((((((((...((.........))...(((((((.....(((....))).......)))))))..((((.(((..((((((.))))..)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..)))........................[..(((((......].))))).......(((.(((.((......((((.(.(((...(((((.(((.(((.))).)))..)))))..(((......[)))((((((..........]))))))..........)))...)))))......((((..(.((((((...((.......))...))))))...).)).).).....((.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..))....(.(((((....))).)).)....))..)))))) Conformation of methylated GGQ in the peptidyl transferase center during translation termination (PTC region); 23S rRNA 6c4h x 12 3.1 RF00005 URS00001BBAFC_562 29403017 0030533 0006412 562 cgcgcgcaacca .<<<>>>..... .((()))..... Conformation of methylated GGQ in the peptidyl transferase center during translation termination (PTC region); P-site tRNA fMet 6c4i A 2904 3.24 RF02540,RF02541 URS0000B21DEA_562 29403017 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaacccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccuu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<.<....<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>..>>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<<.....>>>>>.>>...>>>>.>>>..>>.>.....>>>>>>>.>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<.<<....>>.>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>.>......>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<..<<.......<<<<<<<<....>>>>>>>>....>>............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>.. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((.(........)).)))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((..(.........)...))...)))).)))..)).).....))))))).))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.((((..(((..((((.......))))..))).....(..(((......))))..))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((..((....))..)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((.(((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....)))).)))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((.(((.((((.(..........(((...(((.......(((((((....)))))))....))).............))).).)))).))).)))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).).....((.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..))....(.(((((....))).)).)....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((.(....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))).. Conformation of methylated GGQ in the peptidyl transferase center during translation termination; 23S rRNA 6c4i B 120 3.24 RF00001 URS0000049E57_562 29403017 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Conformation of methylated GGQ in the peptidyl transferase center during translation termination; 5S rRNA 6c4i a 1534 3.24 RF00177,RF01959,RF01960 URS000081169C_562 29403017 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<......>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>..<<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>>.<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((........))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..........)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((.(((....))).))).............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Conformation of methylated GGQ in the peptidyl transferase center during translation termination; 16S rRNA 6c4i x 77 3.24 RF00005 URS000041AF00_562 29403017 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Conformation of methylated GGQ in the peptidyl transferase center during translation termination; E-site or P-site tRNA fMet 6c4i y 77 3.24 RF00005 URS000041AF00_562 29403017 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Conformation of methylated GGQ in the peptidyl transferase center during translation termination; E-site or P-site tRNA fMet 6c5l AA 1504 3.2 RF00177,RF01959,RF01960 URS000080E226_274 29403017 0003735 0005840 274 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<...<..<<<.<<<..<<<..<<.<<<<<<<<.........>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>....<<<<.<<<<<....>>>>>.>>>>...<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>...>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<((....<<<<<.....<...)).>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>.>..........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<.<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<.......<<<<<<...<<<<<<<....>>>>>>>....<<.....>>.....>>>>>>..<<<.<<<..<<<<<.<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>........>>>>.......>..>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<......<<..<<..<<<<....>>>>..>>....>>......>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>.>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<<..>>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>... ....((((....[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((.........)))))))).)))))......(((......(((((((...((...(((((((.(((((....((((.(....).)))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(.(((....)))..))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((.(.((.(((((((......((((((.....))))))....)))))))...))).)))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((.(.(..((...))..).).))...((..]])).....)))))))))).(((......((((....))))....)))...]]]..((((..(((.(((.((...((.(..((((((((((......((........))..........(((((((..(...(.(((.....(((.(((....))).)))....................))).)).((.(((...(((.((.(....((((((.((....))....(((......)))...)))))).....((((.((((((...((..............).)....))))))......((((....)))).........)))).....).)..))...)).)))))....)))))))...)).)))))))).(...(.((((........(..((..((((....))))..))....)........))).))...........(((((((........))))))).......)..).))......(((((((..........)))))))......))...)).)))).)).))..(....((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))......)..(((.(((((....))))).)))}.. Conformation of methylated GGQ in the Peptidyl Transferase Center during translation termination (T. thermophilus); 16S rRNA 6c5l AV 76 3.2 RF00005 URS00005AA258_562 29403017 0030533 0006412 562 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>><<<<<<<.....>>>>>>.>...<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).(((((.......))))).....(((((..]....)))))))))))).... Conformation of methylated GGQ in the Peptidyl Transferase Center during translation termination (T. thermophilus); E-site tRNA PHE OR P-site tRNA PHE (unmodified bases) 6c5l AW 75 3.2 RF00005 URS00005AA258_562 29403017 0030533 0006412 562 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacc <<<<<<...<<<<........>>>>.<<<<.........>>>>.....<<<<<.......>>>>>.>>>>>>... ((((((...((((........))))..(((.........)))..........(.......).....))))))... Conformation of methylated GGQ in the Peptidyl Transferase Center during translation termination (T. thermophilus); E-site tRNA PHE OR P-site tRNA PHE (unmodified bases) 6c5l BA 2901 3.2 RF02540,RF02541,RF00002 URS000080E0F3_274 29403017 0003735 0005840 274 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgggccgcacgcggcccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<....>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....<..<<.<....>.>>..>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<.........<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>.....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><<<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>.>>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><....<<<....>>>......>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<.......>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> .(.......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))(.((((((....)))))).).((((((....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...(((((((((..).))))))))....{.((.((((.(.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).).))))..)))....(((((((((.[.....)))))))))....}.(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...........................)))))))))))))..((.(...((((((.....((((((((((.((((.....((((......)))).....)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((.(((...(((...((((((((.(.((.(((......)))..)))..))))))))..)).)...))).)))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((((((......{...(((......(((.........)))..............((......))...)))......))))))))).))..........]]].)....))))))))))...)))))))(.((((((.....)))))).)....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...(.((....(((((.(((..(((((.((((.((...{{....))))))(((...((((((.(((.(((((.((.....))))))).).....)).))))))..)))(.....((....)).......))))))...)))..)))))(..).....)).)...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))............(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((...(((.((((.............(((..(((.......(((..((....))..)))....)))............)))....)))).)))...)))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....((((((..((..]]]]..)).)))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))...(.........).....(((((((((.......)))))....((((((((.(((.....((((....))))....)))..))))).)))...)))).....). Conformation of methylated GGQ in the Peptidyl Transferase Center during translation termination (T. thermophilus); 23S rRNA 6c5l BB 119 3.2 RF00001 URS00005F2F4B_274 29403017 0003735 0005840 274 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>> ..(((((((((....(((((.((....((((((....(.....)....)))..)))...)).))).))(((.......((.(((((....))))).)).......))).))))))))). Conformation of methylated GGQ in the Peptidyl Transferase Center during translation termination (T. thermophilus); 5S rRNA 6c5l CA 1504 3.2 RF00177,RF01959,RF01960 URS000080E226_274 29403017 0003735 0005840 274 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<...<..<<<.<<<..<<<..<<.<<<<<<<<.........>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<<....>>>>>>.....>>>>>....<<<<.<<<<<....>>>>>.>>>>...<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>...>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<.<<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<....<<<......>>>.......>>>>>>.>..........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>...<<<.....>>>....>>>>>>>.<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<<..>>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(.((((((.........)))))).).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(.(((....))).).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..(.((......((((....)))).....)).)....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((.(.((((((((((......((((((.....))))))....))))))))..))).)))))..((((.((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))..)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(..(((..((...))..)))..)...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((..((((((.((..(((((..((((((((((......((........))..........(((((((..(...((.((......(((((......))))).....................)).))).((.(((...((((((.(....((((((.((....))....(((......)))...)))))).....((((.(((((.(..((..............).)...).))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))...)).)))))))).(...((((((......(((..((..((((....))))..))....)))......))))))......(....((.((((........))).)))....)..)..))))).....(((((((..........)))))))......))...)))))).))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((.(((((....))))).)))}.. Conformation of methylated GGQ in the Peptidyl Transferase Center during translation termination (T. thermophilus); 16S rRNA 6c5l CV 76 3.2 RF00005 URS00005AA258_562 29403017 0030533 0006412 562 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).(((((.......))))).....(((((..]....)))))))))))).... Conformation of methylated GGQ in the Peptidyl Transferase Center during translation termination (T. thermophilus); E-site tRNA PHE OR P-site tRNA PHE (unmodified bases) 6c5l CW 75 3.2 RF00005 URS00005AA258_562 29403017 0030533 0006412 562 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacc <<<<<<...<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>.>>>>>>... (((((....((((........))))..(((.........)))......(.(((.......))).)..)))))... Conformation of methylated GGQ in the Peptidyl Transferase Center during translation termination (T. thermophilus); E-site tRNA PHE OR P-site tRNA PHE (unmodified bases) 6c5l DA 2901 3.2 RF02540,RF02541,RF00002 URS000080E0F3_274 29403017 0003735 0005840 274 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgggccgcacgcggcccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu 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.(.......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...(((.(((((..).)))).)))....{.((.((((.(.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).).))))..)))....(((((((((.[.....)))))))))....}.(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...........................)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((.(((...(((...((((((((.(.((((((......)))).)))..))))))))..)).)...))).)))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((...........(((.((...(((.........)))...)).........((......))...))).......)))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.((...{{....))))))(((....(((((((((.(((((.((.....))))))).).....))))))))...)))(.....((....)).......))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((.(...(((.((((..............((..(((........((((((....)))))).....)))............)).....)))).)))...).)))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...((.((((.(.(((((.........)))))...).((][.[[[))....)))).))...((((..(((...{..)))..)))).(((....))).))]]].].....((((((..((..]]]]..)).)))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))...(.........).....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...)))).....). Conformation of methylated GGQ in the Peptidyl Transferase Center during translation termination (T. thermophilus); 23S rRNA 6c5l DB 119 3.2 RF00001 URS00005F2F4B_274 29403017 0003735 0005840 274 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<.....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>..>>>>>>>>> .((((((((((....(((((..(....(((((((...(.....)...))))..)))...)..))).))(((.......((.(((((....))))).)).......))).)))))))))) Conformation of methylated GGQ in the Peptidyl Transferase Center during translation termination (T. thermophilus); 5S rRNA 6c8d A 14 1.92 29851379 32630 nnnnacuuaagucg .............. .............. RNA-dGMP complex with Mg ion; RNA (5'-R(*(LCC)P*(LCC)P*(LCC)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*G)-3') 6c8d B 14 1.92 29851379 32630 nnnnacuuaagucg .............. .............. RNA-dGMP complex with Mg ion; RNA (5'-R(*(LCC)P*(LCC)P*(LCC)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*G)-3') 6c8e A 14 1.8 29851379 32630 nnnnacuuaagucg .............. .............. RNA-imidazolium-bridged intermediate complex, 4h soaking; RNA (5'-R(*(LCC)P*(LCC)P*(LCC)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*G)-3') 6c8e B 14 1.8 29851379 32630 nnnnacuuaagucg .............. .............. RNA-imidazolium-bridged intermediate complex, 4h soaking; RNA (5'-R(*(LCC)P*(LCC)P*(LCC)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*G)-3') 6c8i A 14 1.77 29851379 32630 nnnnacuuaagucg .............. .............. RNA-activated 2-AIpG monomer complex, 5 min soaking; RNA (5'-R(*(LCC)P*(LCC)P*(LCC)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*G)-3') 6c8i B 14 1.77 29851379 32630 nnnnacuuaagucg .............. .............. RNA-activated 2-AIpG monomer complex, 5 min soaking; RNA (5'-R(*(LCC)P*(LCC)P*(LCC)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*G)-3') 6c8j A 14 1.5 29851379 32630 nnnnacuuaagucg .............. .............. RNA-activated 2-AIpG monomer complex, 15 min soaking; RNA (5'-R(*(LCC)P*(LCC)P*(LCC)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*G)-3') 6c8j B 14 1.5 29851379 32630 nnnnacuuaagucg .............. .............. RNA-activated 2-AIpG monomer complex, 15 min soaking; RNA (5'-R(*(LCC)P*(LCC)P*(LCC)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*G)-3') 6c8k A 14 2.259 29851379 32630 nnnnacuuaagucg .............. .............. RNA-activated 2-AIpG monomer complex, 30 min soaking; RNA (5'-R(*(LCC)P*(LCC)P*(LCC)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*G)-3') 6c8k B 14 2.259 29851379 32630 nnnnacuuaagucg .............. .............. RNA-activated 2-AIpG monomer complex, 30 min soaking; RNA (5'-R(*(LCC)P*(LCC)P*(LCC)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*G)-3') 6c8l A 14 2.25 29851379 32630 nnnnacuuaagucg .............. .............. RNA-activated 2-AIpG monomer complex, 1h soaking; RNA (5'-R(*(LCC)P*(LCC)P*(LCC)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*G)-3') 6c8l B 14 2.25 29851379 32630 nnnnacuuaagucg .............. .............. RNA-activated 2-AIpG monomer complex, 1h soaking; RNA (5'-R(*(LCC)P*(LCC)P*(LCC)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*G)-3') 6c8m A 15 2.4 29851379 32630 nnnnacuuaagucgg ............... ............... RNA-activated 2-AIpG monomer, 1.5h soaking; RNA (5'-R(*(LCC)P*(LCC)P*(LCC)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*GP*G)-3') 6c8m B 14 2.4 29851379 32630 nnnnacuuaagucg .............. .............. RNA-activated 2-AIpG monomer, 1.5h soaking; RNA (5'-R(*(LCC)P*(LCC)P*(LCC)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*G)-3') 6c8n A 15 1.9 29851379 32630 nnnnacuuaagucgg ............... ............... RNA-activated 2-AIpG monomer complex, 2h soaking; RNA (5'-R(*(LCC)P*(LCC)P*(LCC)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*GP*G)-3') 6c8n B 15 1.9 29851379 32630 nnnnacuuaagucgg ............... ............... RNA-activated 2-AIpG monomer complex, 2h soaking; RNA (5'-R(*(LCC)P*(LCC)P*(LCC)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*GP*G)-3') 6c8o A 15 1.85 29851379 32630 nnnnacuuaagucgg ............... ............... RNA-activated 2-AIpG monomer, 3h soaking; RNA (5'-R(*(LCC)P*(LCC)P*(LCC)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*GP*G)-3') 6c8o B 15 1.85 29851379 32630 nnnnacuuaagucgg ............... ............... RNA-activated 2-AIpG monomer, 3h soaking; RNA (5'-R(*(LCC)P*(LCC)P*(LCC)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*GP*G)-3') 6cab A 14 2.5 29851379 32630 nnnnacuuaagucg .............. .............. RNA-dGMP complex with Sr ion; RNA (5'-R(*(LCC)P*(LCC)P*(LCC)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*G)-3') 6cab B 14 2.5 29851379 32630 nnnnacuuaagucg .............. .............. RNA-dGMP complex with Sr ion; RNA (5'-R(*(LCC)P*(LCC)P*(LCC)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*G)-3') 6cae 1A 2871 2.6 RF02540,RF02541,RF00002 URS00001698E8_300852 29625040 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<....<<<<........>>>..>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..<...........>...>>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<.<<....>>.>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((..(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((.(..((..(......)....)))..)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((..((.........))...))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((.(((((((((.(.........(((((..(((......(((((.((....)).)))))...)))............)))))).))))))))).))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((...)))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with NOSO-95179 antibiotic and bound to mRNA and A-, P- and E-site tRNAs at 2.6A resolution; 23S Ribosomal RNA 6cae 1B 120 2.6 RF00001 URS000080DEE8_300852 29625040 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> (((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).))))))))))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with NOSO-95179 antibiotic and bound to mRNA and A-, P- and E-site tRNAs at 2.6A resolution; 5S Ribosomal RNA 6cae 1a 1500 2.6 RF00177,RF01959,RF01960 URS000080DFED_300852 29625040 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<..[.>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>.......]..<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<......>>....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((((((....))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((..((((....))))..))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((...(((.(((....))).)))....(((....)))....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the Thermus thermophilus 70S ribosome in complex with NOSO-95179 antibiotic and bound to mRNA and A-, P- and E-site tRNAs at 2.6A resolution; 16S Ribosomal RNA 6cae 1v 13 2.6 29625040 10665 aaaaaugguuuuc ............. ............. Crystal structure of the Thermus thermophilus 70S ribosome in complex with NOSO-95179 antibiotic and bound to mRNA and A-, P- and E-site tRNAs at 2.6A resolution; mRNA 6cae 1w 73 2.6 RF00005 URS00003179F7_562 29625040 0030533 0006412 562 gggugaunagcucagggagagcaccucccunacnaggaggggnucggcggnucgaucccgucaucacccacca <<<<<<...<<<<.....>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>.>>>>>>.... ((((((...((((...[.)))).(((((.......))))).....(.(((..]....))).).)))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with NOSO-95179 antibiotic and bound to mRNA and A-, P- and E-site tRNAs at 2.6A resolution; A-site and E-site tRNAs 6cae 1x 76 2.6 RF00005 URS000041AF00_562 29625040 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with NOSO-95179 antibiotic and bound to mRNA and A-, P- and E-site tRNAs at 2.6A resolution; P-site tRNA 6cae 1y 74 2.6 RF00005 URS00003179F7_562 29625040 0030533 0006412 562 gggugaunagcucaggggagagcaccucccunacnaggaggggnucggcggnucgaucccgucaucacccacca <<<<<<<..<<<<......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... ((((((...((((...[..)))).(((((.......))))).....(((((..]....))))).)))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with NOSO-95179 antibiotic and bound to mRNA and A-, P- and E-site tRNAs at 2.6A resolution; A-site and E-site tRNAs 6cae 2A 2800 2.6 RF02540,RF02541,RF00002 URS00001698E8_300852 29625040 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu 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(((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....(())....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((.(..(...............).)..)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((.().)))))))).))..........]]].)....))))))))))...)))))))(((((((..)))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........(((((...((......(((((.((....)).)))))...)).............)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))((((.))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with NOSO-95179 antibiotic and bound to mRNA and A-, P- and E-site tRNAs at 2.6A resolution; 23S Ribosomal RNA 6cae 2B 120 2.6 RF00001 URS000080DEE8_300852 29625040 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>>. ..(((((((((....((((((.(....(((((((...(.....)...))))..)))...).)))).))(((.......((((((((....)))))))).......))).))))))))).. Crystal structure of the Thermus thermophilus 70S ribosome in complex with NOSO-95179 antibiotic and bound to mRNA and A-, P- and E-site tRNAs at 2.6A resolution; 5S Ribosomal RNA 6cae 2a 1503 2.6 RF00177,RF01959,RF01960 URS000080DFED_300852 29625040 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggau .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<......>>....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((((((....))))))).(..(.(....).)..).)))))))).((.((....((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...))..))))....)))))))..[)).)))))))).(...(((((((.....(((..((..(.((....)).)..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}... Crystal structure of the Thermus thermophilus 70S ribosome in complex with NOSO-95179 antibiotic and bound to mRNA and A-, P- and E-site tRNAs at 2.6A resolution; 16S Ribosomal RNA 6cae 2v 13 2.6 29625040 10665 aaaaaugguuuuc ............. ............. Crystal structure of the Thermus thermophilus 70S ribosome in complex with NOSO-95179 antibiotic and bound to mRNA and A-, P- and E-site tRNAs at 2.6A resolution; mRNA 6cae 2w 73 2.6 RF00005 URS00003179F7_562 29625040 0030533 0006412 562 gggugaunagcucagggagagcaccucccunacnaggaggggnucggcggnucgaucccgucaucacccacca <<<<<<<..<<<<.....>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... ((((((...((((...[.)))).(((((.......))))).....(.(((..]....))).).)))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with NOSO-95179 antibiotic and bound to mRNA and A-, P- and E-site tRNAs at 2.6A resolution; A-site and E-site tRNAs 6cae 2x 76 2.6 RF00005 URS000041AF00_562 29625040 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(.(((..]....))).)))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with NOSO-95179 antibiotic and bound to mRNA and A-, P- and E-site tRNAs at 2.6A resolution; P-site tRNA 6cae 2y 73 2.6 RF00005 URS00003179F7_562 29625040 0030533 0006412 562 gggugaunagcucagggagagcaccucccunacnaggaggggnucggcggnucgaucccgucaucacccacca <<<<<<...<<<<.....>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>.>>>>>>.... (((((.(..((((...[.)))).(((((.......))))).......(((..]....)))..).))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with NOSO-95179 antibiotic and bound to mRNA and A-, P- and E-site tRNAs at 2.6A resolution; A-site and E-site tRNAs 6cao A 1512 3.45 RF00177,RF01959,RF01960 URS000080E226_300852 30139800 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauccuuucu ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<.......>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<.<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<<....>>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>..>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>........... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.....)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((.(..(((((((....)))))))...((((....)))..).)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(....(((.....)))..)...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((.((((((...(.((((....(((....))).)))).)..)))))).))))))..))).))))..).))...)..)..(((((((((....)))))))))}.......... Structure of the ribosomal decoding complex at ambient temperature; 16S Ribosomal RNA rRNA 6cao W 15 3.45 URS000080E1F5_300852 30139800 300852 gggauugaaaauccc <<<<<.....>>>>> .(((.......))). Structure of the ribosomal decoding complex at ambient temperature; RNA (5'-R(*GP*GP*GP*AP*UP*UP*GP*AP*AP*AP*AP*UP*CP*CP*C)-3') 6cap A 1512 3.4 RF00177,RF01959,RF01960 URS0000D77903_300852 0003735 0005840 300852 uggagagucugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauccuuucu ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<.......>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<.<..<<<<<<<....>>>>>>>...<<<<....>>>>..>.>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<<..>>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>........... ....((((..[.[[[[.)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.....)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..((((((((....((((((((....((((((....((........)).......))))))....).......((....)).)))))))...)))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))..]]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((.(.....((((....))))......((((....))))...)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((........((.....)).......))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((.((((((...(.((((....(((....))).)))).)..)))))).))))))..))).))))..).))...)..)..(((((((((....)))))))))}.......... Crystal Structure of 30S ribosomal subunit from Thermus thermophilus in complex with Sisomicin; 16S Ribosomal RNA rRNA 6cap W 15 3.4 URS000080E1F5_300852 300852 gggauugaaaauccc <<<<<.....>>>>> .(((.......))). Crystal Structure of 30S ribosomal subunit from Thermus thermophilus in complex with Sisomicin; RNA (5'-R(*GP*GP*GP*AP*UP*UP*GP*AP*AP*AP*AP*UP*CP*CP*C)-3') 6caq A 1512 3.4 RF00177,RF01959,RF01960 URS0000D77903_300852 0003735 0005840 300852 uggagagucugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauccuuucu ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<.......>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<<....>>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<<....>>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<<..>>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>........... ....((((..[.[[[[.)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.....)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))..]]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((.(....(((((....))))).....((((....))))...)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...(....((.....)).).....))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((.((((((...(.((((....(((....))).)))).)..)))))).))))))..))).))))..).))...)..)..(((((((((....)))))))))}.......... Crystal Structure of 30S ribosomal subunit from Thermus thermophilus; 16S Ribosomal RNA rRNA 6caq W 15 3.4 URS000080E1F5_300852 300852 gggauugaaaauccc <<<<<.....>>>>> .(((.......))). Crystal Structure of 30S ribosomal subunit from Thermus thermophilus; RNA (5'-R(*GP*GP*GP*AP*UP*UP*GP*AP*AP*AP*AP*UP*CP*CP*C)-3') 6car A 1511 3.4 RF00177,RF01959,RF01960 URS0000D77929_300852 30113694 0003735 0005840 300852 uggagagucugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggaucuuucu ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<.......>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<.<..<<<<<<<....>>>>>>>...<<<<....>>>>..>.>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.......... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.....)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..((((((((....((((((((....((((((....((........)).......))))))....).......((....)).)))))))...)))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((.(....(((((....))))).....((((....))))...)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..((....((.....)).).)...))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}......... Serial Femtosecond X-ray Crystal Structure of 30S ribosomal subunit from Thermus thermophilus in complex with Sisomicin; 16S Ribosomal RNA rRNA 6car W 15 3.4 URS000080E1F5_300852 30113694 300852 gggauugaaaauccc <<<<<.....>>>>> .(((.......))). Serial Femtosecond X-ray Crystal Structure of 30S ribosomal subunit from Thermus thermophilus in complex with Sisomicin; RNA (5'-R(*GP*GP*GP*AP*UP*UP*GP*AP*AP*AP*AP*UP*CP*CP*C)-3') 6cas A 1512 3.5 RF00177,RF01959,RF01960 URS0000D77929_300852 30113694 0003735 0005840 300852 uggagagucugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauccuuucu ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<.......>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<<....>>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<<..>>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>........... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.....)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((......(((((....))))).....((((....))))....))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..((....((.....)).).)...))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((.((((((...(.((((....(((....))).)))).)..)))))).))))))..))).))))..).))...)..)..(((((((((....)))))))))}.......... Serial Femtosecond X-ray Crystal Structure of 30S ribosomal subunit from Thermus thermophilus in complex with N1MS; 16S Ribosomal RNA rRNA 6cas W 15 3.5 URS000080E1F5_300852 30113694 300852 gggauugaaaauccc <<<<<.....>>>>> .(((.......))). Serial Femtosecond X-ray Crystal Structure of 30S ribosomal subunit from Thermus thermophilus in complex with N1MS; RNA (5'-R(*GP*GP*GP*AP*UP*UP*GP*AP*AP*AP*AP*UP*CP*CP*C)-3') 6cb1 1 1370 4.6 RF02540,RF02543 URS0000D56C2D_1247190 29512650 0003735 0005840 1247190 guuugaccucaaaucagguaggaguacccgcugaaaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuuugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaugguguuuugugcccucugcuccuuguggguaggggaaucucgcauuucacugggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccugguuccugccgaagaacguagaguuaaggugccggaauacacgcucaucagaggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacuugauagaauaaucuagcgaaaccacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuauggcgaauugcaaug ..........................<<<<<<....>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..<<<..<........<<.<<<<<<...>>>>>>.>>........>....<<<<<<<.<<<.<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>>..>>>>>>>.....>>>>>>>>>>........<<<<<<<...>>>>>>>.....<<<<<<......>>>>>>..>>>..................................<<....>>...............<<<......>>>..................................<<<<<.<<<<<<.....<<<<...<<<<.<<<<<<<<<.....>>>>>>>>>.....>>>>...>>>>..<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>>..>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>.>>>>>....<<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<......>...>>>>.>>.>>....>>>>>>.>>>>>>..<<..>>..<<<<<<.......<<<<<<<..<<<<(((.....<<<<<<.....<<.))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>>..<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<...........((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<.......>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>.......<<<<....>>>>.>....>>...........<<..........<<<<<<.....>>>>>>......>>.......<<<..>>>........... ..........................(((((......)))).).........((....))...((((......((.....)).....))))...((((.........(((.((.(((...))).)).))....)........((.((((.(((((((.((((((((.(((...({((((......)))))[[(...).(((....}]])))....))).))))..)))).)))....)))))))).))...)....(((((((...))))))).....((((((......))))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....((((...((((.((.((((((.....)))))).)).....))))...))))..((((((((((((((.((((((((.......(((((((......((((((....)))))).......))))))).....))))).))).))))))........(((....)))....))))))))....)))))).)))))....((((((....((((((.((((((..(((...(((.......)))...)))...(.(((..(((((....)))))...))).).(((((.((....(....)....))..))).))....)))))).))))))..((..))..((((((.......(((((((...((([[[...(.((((((......(.]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((..........[[(((.((...((....(((....)))........((((((........))))))....))....))...(((((........)))))]]((((.((((((((...((((....)))...(...((((((...((((.((((((((((((((((((.......))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....))))..)))))))).))).......((((....))))))....))...........((.(........(((((((..).)))))).....))).......(((())))........... Yeast nucleolar pre-60S ribosomal subunit (state 3); 35S pre-ribosomal RNA miscRNA 6cb1 2 158 4.6 RF00002 URS00001BF64E_1247190 29512650 0003735 0005840 1247190 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<<((....>>>>.....<.<<<<.....))............>.>>>..>...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Yeast nucleolar pre-60S ribosomal subunit (state 3); 5.8S rRNA 6cb1 6 87 4.6 URS000013305B_1247190 29512650 1247190 ccuucucaaacauucuguuugguagugagugauacucuuuggaguuaacuugaaauugcuggccuuuaggcgaacaauguucuuaaa ......<<<<<.....>>>>>.....<<<<...<<<<....>>>>..>>>>..........<<<<..>>>>................ ......(((((.....)))))....(((((...((((....))))..))))..).......((((..))))................ Yeast nucleolar pre-60S ribosomal subunit (state 3); ITS2 6cb3 A 99 1.891 URS0000D77934_1358 29805037 1358 aaaggggaguagcgucgggaaaccgaaacaaagucgucaauucgugaggaaacucaccggcuuuguugacauacgaaaguauguuuagcaagaccuuuc <<<<<......<<.<<<<....>>>><<<<<<<<<........<<<<<....>>>>>.>>>>>>>>><<<<<<<....>>>>>>>..>>....>>>>>. (((((......((.((((....))))((((((((((.......(((((....)))))))))))))))(((((((....)))))))..))....))))). Crystal structure of the L.Lactis YkoY riboswitch bound to cadmium; RNA (99-MER) 6cb3 B 99 1.891 URS0000D77934_1358 29805037 1358 aaaggggaguagcgucgggaaaccgaaacaaagucgucaauucgugaggaaacucaccggcuuuguugacauacgaaaguauguuuagcaagaccuuuc <<<<<......<<.<<<<....>>>><<<<<<<<<........<<<<<....>>>>>.>>>>>>>>><<<<<<<....>>>>>>>..>>....>>>>>. (((((......((.((((....))))((((((((((.......(((((....)))))))))))))))(((((((....)))))))..))....))))). Crystal structure of the L.Lactis YkoY riboswitch bound to cadmium; RNA (99-MER) 6cbd B 19 2.203 URS000080E33F_32644 29576456 32644 uucacauugcccaagucuu ................... ................... Crystal Structure of Human Argonaute2 Bound to Three Tryptophans; Guide RNA 6cbd C 10 2.203 URS000080E203_32644 29576456 32644 caaugugaaa .......... .......... Crystal Structure of Human Argonaute2 Bound to Three Tryptophans; Target RNA 6cfj 1A 2871 2.8 RF02540,RF02541,RF00002 URS00001698E8_300852 29410130 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>....<<<<<.....<<....>>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<....<<<<........>>>..>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..<<......(..>>...>>>.........<<......>>.).>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<.<<....>>.>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((...((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...((((((((.(...((..........)..).)..))))))))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((..((.........))...))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((.((((((.(......[..(((((..(((......((((.(((....))).))))...)))..........].)))))).)))))).)))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..(((...)))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with histidyl-CAM and bound to mRNA and A-, P-, and E-site tRNAs at 2.8A resolution; 23S Ribosomal RNA 6cfj 1B 120 2.8 RF00001 URS000080DEE8_300852 29410130 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the Thermus thermophilus 70S ribosome in complex with histidyl-CAM and bound to mRNA and A-, P-, and E-site tRNAs at 2.8A resolution; 5S Ribosomal RNA 6cfj 1a 1500 2.8 RF00177,RF01959,RF01960 URS000080DFED_300852 29410130 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<......>>....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((((((....))))))).)))))......(((......((((((((..((...(((((((.(((((......((((....)))).......)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((.(((....))).)))....(((....)))....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the Thermus thermophilus 70S ribosome in complex with histidyl-CAM and bound to mRNA and A-, P-, and E-site tRNAs at 2.8A resolution; 16S Ribosomal RNA 6cfj 1v 13 2.8 29410130 10665 aaaaauguucuaa ............. ............. Crystal structure of the Thermus thermophilus 70S ribosome in complex with histidyl-CAM and bound to mRNA and A-, P-, and E-site tRNAs at 2.8A resolution; mRNA 6cfj 1w 74 2.8 RF00005 URS00005AA258_562 29410130 0030533 0006412 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[..)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with histidyl-CAM and bound to mRNA and A-, P-, and E-site tRNAs at 2.8A resolution; A-site and E-site tRNAs 6cfj 1x 76 2.8 RF00005 URS000041AF00_550538 29410130 0030533 0006412 550538 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with histidyl-CAM and bound to mRNA and A-, P-, and E-site tRNAs at 2.8A resolution; P-site tRNA 6cfj 1y 74 2.8 RF00005 URS00005AA258_562 29410130 0030533 0006412 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((......)))).((((.........)))).....(((((.......)))))))))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with histidyl-CAM and bound to mRNA and A-, P-, and E-site tRNAs at 2.8A resolution; A-site and E-site tRNAs 6cfj 2A 2800 2.8 RF02540,RF02541,RF00002 URS00001698E8_300852 29410130 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<..........>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<..>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<..>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<<.....<<<<<<<<....>>>>>>>>..>>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...((((((((.....))))))))....{.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).))))....(((((((((.[.....)))))))))....}.(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....(())....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((.(....(..........)....)..))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((....)))))))).))..........]]].)....))))))))))...)))))))(((((.(..).)))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((....))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........(((((..(((.......((((.((....)).))))....)))............)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))(.((...(((((((.(.(((((.........)))))...).((.[.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(............(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with histidyl-CAM and bound to mRNA and A-, P-, and E-site tRNAs at 2.8A resolution; 23S Ribosomal RNA 6cfj 2B 120 2.8 RF00001 URS000080DEE8_300852 29410130 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>. ..(((((((((....((((((.(....(((((((...(.....)...))))..)))...).)))).))(((.......((((((((....)))))))).......))).))))))))).. Crystal structure of the Thermus thermophilus 70S ribosome in complex with histidyl-CAM and bound to mRNA and A-, P-, and E-site tRNAs at 2.8A resolution; 5S Ribosomal RNA 6cfj 2a 1503 2.8 RF00177,RF01959,RF01960 URS000080DFED_300852 29410130 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggau .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<.<<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<......>>....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((.(....).)))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........((((((...(...(((((((...(((.(((....))).)))...((((....))))...)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).))))).....))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}... Crystal structure of the Thermus thermophilus 70S ribosome in complex with histidyl-CAM and bound to mRNA and A-, P-, and E-site tRNAs at 2.8A resolution; 16S Ribosomal RNA 6cfj 2v 13 2.8 29410130 10665 aaaaauguucuaa ............. ............. Crystal structure of the Thermus thermophilus 70S ribosome in complex with histidyl-CAM and bound to mRNA and A-, P-, and E-site tRNAs at 2.8A resolution; mRNA 6cfj 2w 72 2.8 RF00005 URS00005AA258_562 29410130 0030533 0006412 562 cccgganagcucagggagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<..<<<<.....>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((...[.)))).((((.........))))......((((..]....)))).))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with histidyl-CAM and bound to mRNA and A-, P-, and E-site tRNAs at 2.8A resolution; A-site and E-site tRNAs 6cfj 2x 76 2.8 RF00005 URS000041AF00_550538 29410130 0030533 0006412 550538 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with histidyl-CAM and bound to mRNA and A-, P-, and E-site tRNAs at 2.8A resolution; P-site tRNA 6cfj 2y 73 2.8 RF00005 URS00005AA258_562 29410130 0030533 0006412 562 gcccgganagcucagggagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<.....>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[.)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with histidyl-CAM and bound to mRNA and A-, P-, and E-site tRNAs at 2.8A resolution; A-site and E-site tRNAs 6cfk 1A 2872 2.7 RF02540,RF02541,RF00002 URS00001698E8_300852 29410130 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<...................>>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<......>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((..(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...((((((((.(.((((((......)))).)))..))))))))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((...................))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((..))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((.((((((.(.........(((((..(((......(((((.((....)).)))))...)))............)))))).)))))).)))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..((((.))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with D-histidyl-CAM and bound to protein Y (YfiA) at 2.7A resolution; 23S Ribosomal RNA 6cfk 1B 120 2.7 RF00001 URS000080DEE8_300852 29410130 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the Thermus thermophilus 70S ribosome in complex with D-histidyl-CAM and bound to protein Y (YfiA) at 2.7A resolution; 5S Ribosomal RNA 6cfk 1a 1500 2.7 RF00177,RF01959,RF01960 URS000080DFED_300852 29410130 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>.................>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((.(((..))).)))).)))))......(((......((((((((..((...(((((((.(((((.....(((((....)))))......)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((...(((.(((....))).)))....((......))....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the Thermus thermophilus 70S ribosome in complex with D-histidyl-CAM and bound to protein Y (YfiA) at 2.7A resolution; 16S Ribosomal RNA 6cfk 2A 2867 2.7 RF02540,RF02541,RF00002 URS00001698E8_300852 29410130 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..................>>>......................>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<.......<<<<<<......>>>>>>....>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((..))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((...((.(((......)))..))...)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((........((((.((....(.(......)).....)).........(........)...))))....)))))))))).))..........]]].)....))))))))))...)))))))(((((((())))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..((((..((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....).))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((.((.((((((.(.........(((((..(((.......((((.((....)).))))....)))............)))))).)))))).)).))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))((((.))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with D-histidyl-CAM and bound to protein Y (YfiA) at 2.7A resolution; 23S Ribosomal RNA 6cfk 2B 120 2.7 RF00001 URS000080DEE8_300852 29410130 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the Thermus thermophilus 70S ribosome in complex with D-histidyl-CAM and bound to protein Y (YfiA) at 2.7A resolution; 5S Ribosomal RNA 6cfk 2a 1504 2.7 RF00177,RF01959,RF01960 URS000080DFED_300852 29410130 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>.....<.....>.....>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((((((....))))))).(...((....))...).)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the Thermus thermophilus 70S ribosome in complex with D-histidyl-CAM and bound to protein Y (YfiA) at 2.7A resolution; 16S Ribosomal RNA 6cfl 1A 2872 2.6 RF02540,RF02541,RF00002 URS00001698E8_300852 29410130 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<......>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((..(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...((((((((.(.((((((......)))).)))..))))))))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((.((((((.(......[..(((((..(((......(((((.((....)).)))))...)))..........].)))))).)))))).)))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..((((.))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with lysyl-CAM and bound to protein Y (YfiA) at 2.6A resolution; 23S Ribosomal RNA 6cfl 1B 120 2.6 RF00001 URS000080DEE8_300852 29410130 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the Thermus thermophilus 70S ribosome in complex with lysyl-CAM and bound to protein Y (YfiA) at 2.6A resolution; 5S Ribosomal RNA 6cfl 1a 1500 2.6 RF00177,RF01959,RF01960 URS000080DFED_300852 29410130 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>.................>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((.(((..))).)))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(.(((....))).).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((...(((.(((....))).)))....(((....)))....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the Thermus thermophilus 70S ribosome in complex with lysyl-CAM and bound to protein Y (YfiA) at 2.6A resolution; 16S Ribosomal RNA 6cfl 2A 2867 2.6 RF02540,RF02541,RF00002 URS00001698E8_300852 29410130 0003735 0005840 300852 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<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..<<.........>>...>>>......................>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<.........<<<<<......>>>>>......>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((..))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...((((((((.(.((.(((......)))..)))..))))))))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((........((((.((....((.......)).....)).........((......))...))))....)))))))))).))..........]]].)....))))))))))...)))))))(((((((())))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..((((..((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....).))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((.((((((.(.........(((((..(((.......((((.((....)).))))....)))............)))))).)))))).)))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(..(.).......(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with lysyl-CAM and bound to protein Y (YfiA) at 2.6A resolution; 23S Ribosomal RNA 6cfl 2B 120 2.6 RF00001 URS000080DEE8_300852 29410130 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the Thermus thermophilus 70S ribosome in complex with lysyl-CAM and bound to protein Y (YfiA) at 2.6A resolution; 5S Ribosomal RNA 6cfl 2a 1504 2.6 RF00177,RF01959,RF01960 URS000080DFED_300852 29410130 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>.....<......>....>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>.>>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((...(((((((....))))))).(...((....))...).)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the Thermus thermophilus 70S ribosome in complex with lysyl-CAM and bound to protein Y (YfiA) at 2.6A resolution; 16S Ribosomal RNA 6chr A 621 3.7 RF02012,RF00029 URS0000E60B9F_2885 30410046 0000373 2885 gugcgacaagaaguucaggaagggauugaggugaaaguccuccucccgaaucguucaugggagagucuauccagacuugcguagcgaguaaucgcuaggugagaagcucuggagacaauguaccugcccuucaauuggaggugccagggcuaggcuuuguuccuauggcuagcgaaagcgaauacagguuauuaggcgucgugaaaacaaaacucuuucgacauaagggagagguagaugaguuacccuccuuuuuaugggguaacugaacgaucaauaucuaccggcguagacugugagccuaaaggaaacgaaugaaagugucccuuccugggaacuugguaagcccaauagacucccucugggaaaccagaggaggaguaagagcaaucuuacuuaucgucuaguggguaaaagacauaauaggaagcaaaugcuugguuguaacgaucgagauagaaucuguugauuuaagcugaaaggcugcagacuuauuaaauggguguucugcuguauggcguucgcgccuaagcagcagaaugcgugagccgugugcgaugaaagucgcaagcacgguucugauggggggaaaacgagagaucgucuaccuauccaacucaa ..[[..<<<....<<<<<<<<<<<<<.<<<<.......>>>><<<<<<...((((..>>>>>><<<<<.<<<<<<<<<<<.<<<<<<....>>>>>>.>>>>>..]]>>>>>>.........<<<<..................>>>>...>>>>>..<<<<<<..<<<<.<<....>>...<<<<<........<<<<<.................<<.......>>......<<<<<..<<<<<<<<.........>>>>>>>>..))))......>>>>>..>>>>>...>>>>>>>>>...>>>.>>>..........>>>>>>>>>>>>>...>>>....<<<<<.<<<<<..<<<<<<<....>>>>>>>..<<<<<<<<....>>>>>>>>...>>>>>.>>>>>........<<<<<....<<.....<<<<<<<.....>>>>>>>...<<<<......>>>>.<<<<....>>>>>>.....>>>>>.....<<<<<<<<<<<<..<<<<....>>>>...>>>>>>>>>>>>..<<<<<<<<<<<<<<....>>>>>..>>>>>>>>>.....<<<<<...<<........>>...>>>.>>........ ..{{..((((...(((((((((((((.((((.......))))(((((....[[[[[..)))))(((((.((((((((((..((((.(....).))))..))))..}}))))))..........((....................))....)))))..((((((..((((.((....))...(((((.......[((((.(...................(..).........((((((..((((((((.].......)))))))).]]]]]......))))))).)))).[.)))))))))...))).)))..........)))))))))))))..))))....(((((.(((((..(.(((((....))))).)..((((((((....))))))))...))))).)))))........(((((....((.....(((((((.....)))))))..[((((...]..)))).((((....)))))).....))))).....((((((((((((..(((......)))...))))))))))))..((((((((((((((....)))))..))))))))).....(..((...((.(....).))...))...).....].. Crystal structure of a group II intron lariat with an intact 3' splice site (pre-2s state); RNA (621-MER) 6chr B 13 3.7 URS0000E60B8F_2885 30410046 2885 uguuuauuaaaaa ............. ............. Crystal structure of a group II intron lariat with an intact 3' splice site (pre-2s state); RNA (5'-R(P*UP*GP*UP*UP*UP*AP*UP*UP*AP*AP*AP*AP*A)-3') 6cih A 616 3.676 RF02012,RF00029 URS0000E60BD4_2885 30410046 0000373 2885 gugcgacaagaaguucaggaagggauugaggugaaaguccuccucccgaaucguucaugggagagucuauccagacuugcguagcgaguaaucgcuaggugagaagcucuggagacaauguaccugcccuucaauuggaggugccagggcuaggcuuuguuccuauggcuagcgaaagcgaauacagguuauaggcgucgugaaaacaaaacucuuucgacauaagggagagguagaugaguuacccuccuuuuuaugggguaacugaacgaucaauaucuaccggcguagacugugagccuaaaggaaacgaaugaaagugucccuuccugggaacuugguaagcccaauagacucccucugggaaaccagaggaggaguaagagcaaucuuacuuaucgucuaguggguaaaagacauaauaggaagcaaaugcuugguuguaacgaucgagauagaaucuguugauuuaagcugaaaggcugcagacuuauuaaauggguguucugcuguauggcguucgcgccuaagcagcagaaugcgugagccgugugcgaugaaagucgcaagcacgguucugauggggggaaaacgagagaucgucuaccuauccaac ..[[..<<<....<<<<<<<<<<<<<.<<<<.......>>>><<<<<<.(((({{..>>>>>><<<<<.<<<<<<<<<<<.<<<<<<....>>>>>>.>>>>>..]]>>>>>>......<<.<<<....................>>>>>.>>>>>..<<<<<<..<<<<.<<....>>...<<<<<.......<<<<<.............<<<<<.........>>>>>.<<<<<<..<<<<<<<<.........>>>>>>>>.}}.))))....>>>>>.>>>>>>...>>>>>>>>>...>>>.>>>..........>>>>>>>>>>>>>...>>>....<<<<<.<<<<<..<<<<<<<....>>>>>>>..<<<<<<<<....>>>>>>>>...>>>>>.>>>>>........<<<<<<...<<.....<<<<<<<.....>>>>>>>...<<<<......>>>>.<<<<....>>>>>>....>>>>>>.....<<<<<<<<<<<<..<<<<....>>>>...>>>>>>>>>>>>..<<<<<<<<<<<<<<....>>>>>..>>>>>>>>>...<<<<<.<.<.<<<<....>>>>.>.>>..>>>>.. ..{{..((((...(((((((((((((.((((.......))))((((((.[[[[[[..))))))(((((.(((((((((((.(((((......))))).)))))..}}))))))......(..((((.................).))).).)))))...((((...((((.((....))...(((((......[((((((............(((.............))).((((((..((((((((.].......))))))))..]]]]]]....))))))))))))...)))))))))....)).))...........)))))))))))))..))))....(((((.(.(((..(((((((....)))))))...(((((((....)))))))....))).).)))))........(((((....((.....((.((((.....)))).))..[((((...]..)))).((((....)))))).....))))).....((((((((((((..((((....))))...))))))))))))..((((((((((((((....)))))..)))))))))...(((..((...(((......)))...))...))).. Crystal structure of a group II intron lariat in the post-catalytic state; RNA (696-MER) 6cih B 14 3.676 URS0000E60B77_2885 30410046 2885 uguuuauuaaaaac .............. .............. Crystal structure of a group II intron lariat in the post-catalytic state; RNA (5'-R(P*UP*GP*UP*UP*UP*AP*UP*UP*AP*AP*AP*AP*AP*C*-3') 6czr 1A 2872 3.14 RF02540,RF02541,RF00002 URS000080E0F3_300852 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<....<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.....>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<...<<<.......>>>...>>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<.......<<<<<<<......>>>>>>>....>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((..(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((.(.((((((......)))).)))..)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...(((((((((.((((((.((.....))))))).).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((.(.((((((.(......[..(((((..(((......((((((((....))))))))...)))..........].)))))).)))))).).)))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..((((.))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) The structure of amicetin bound to the 70S ribosome; 23S Ribosomal RNA 6czr 1B 120 3.14 RF00001 URS000080DFF2_300852 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>. .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). The structure of amicetin bound to the 70S ribosome; 5S Ribosomal RNA 6czr 1a 1500 3.14 RF00177,RF01959,RF01960 URS0000E60BC4_300852 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<...<<<<<<......>>>>>.>...>>>>>....<<<<.<<<<<....>>>>>.>>>>...<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<((....<<<<<.....<...)).>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>.>..........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<.<......<<........>>..........<<<<<<<.......<<<<<<<..<<<<<<<....>>>>>>>...<<<......>>>..>>>>>>>..<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<...<<.....>>.>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>..>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((..)))))))).)))))......(((......((((((((..((...(((((((.(((((.....(((((....)))))......)))))....((((.(((((....))))).))))...(.((...)).).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....)))).....((((...(....((((.....)))).....)....)))).......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((..((((((.((..(((((..((((.(((((......((........))..........(((((((..(...(((((((...((((((......))))))...((((....))))...)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).))).)))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))).))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.... The structure of amicetin bound to the 70S ribosome; 16S Ribosomal RNA 6czr 2A 2867 3.14 RF02540,RF02541,RF00002 URS000080E0F3_300852 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu .<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>....<<<<<.....<......>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<....<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.....>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<.......>>>....>>......................>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[....>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<.......<<<<<<......>>>>>>....>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>. (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.)))....(((((((...(((]]..]].)))......)))))).).)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((....(((((((.....))))))).....[.(((((((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).))))....(((((((((.{.....)))))))))....].(((((}.[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.)))))))))))...(.(........).).((((((....(((((.(((((((..(((...(((.....)))...)))...((....))..((((.....))))....((..))...))))))).)))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...((((((.((...(((...(((.((((...((.(.(......).)..))...)))).)))..)).)...)).))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((((.((.........(((.((....((.......)).....)).........(........)...))).....)).))))))).))..........]]].)....))))))))))...)))))))(((((((..)))))))....))))))(.(((((...(((.......((((.(((....)))))))....)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....((((..(((..(((((.((((.(((..{{..).))))))((....((((((((.(((((((.((.....)))))))))......))))))))...))(...((((..)))).....))))))...)))...))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).[..(((((......].)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((....((..(((((........[..(((((..((.(.......(((.(......).))).....)))..........].)))))..)))))..))....)))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...((.((((.(.(((((.........)))))...).((][.[[[))....))).)))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(((...)).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) The structure of amicetin bound to the 70S ribosome; 23S Ribosomal RNA 6czr 2B 120 3.14 RF00001 URS000080DFF2_300852 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>>> .(((.((((((....((.(((((....(((((((...(.....)...))))..)))...)))))..))(((.......((((((((....)))))))).......))).)))))).))). The structure of amicetin bound to the 70S ribosome; 5S Ribosomal RNA 6czr 2a 1504 3.14 RF00177,RF01959,RF01960 URS0000E60BC4_300852 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<......<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<.....>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>...>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<..))).>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<.<<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<....<<<......>>>.......>>>>>>.>..........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>.....<......>....>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>.>>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>..... .....(((...[.[[[...))).((((.(((((..((((.((((....(((.(((..(((..((.((((.(((((..))))).)))).)))))......(((.......((((((...((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...(((.....))).)))))))..)).)))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(.(((....)))..))))).)).).))))..((((......((((....)))).....)))).....((((...(....((((.....)))).....)....)))).......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((.(((((((......((((((.....))))))....)))))))...)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((..((((((.((..(((.(..((((((((((......((........))........(.(((((((......(((((((...(((((((....))))))).(..............).)))))))..((.(((...((((((.(....((((((.((....))....(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..).))).....(((((((......]...)))))))......))...)))))).))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.... The structure of amicetin bound to the 70S ribosome; 16S Ribosomal RNA 6d06 B 23 2.55 URS0000A7634A_9606 30581135 9606 gcucgcgaugcungagggcucug ....................... ....................... Human ADAR2d E488Y mutant complexed with dsRNA containing an abasic site opposite the edited base; RNA (5'-R(*GP*CP*UP*CP*GP*CP*GP*AP*UP*GP*CP*UP*(8AZ)P*GP*AP*GP*GP*GP*CP*UP*CP*UP*G)-3') 6d06 C 23 2.55 URS0000E60BA4_9606 30581135 9606 cagagcccccnagcaucgcgagc ....................... ....................... Human ADAR2d E488Y mutant complexed with dsRNA containing an abasic site opposite the edited base; RNA (5'-R(*CP*AP*GP*AP*GP*CP*CP*CP*CP*CP*NP*AP*GP*CP*AP*UP*CP*GP*CP*GP*AP*GP*C)-3') 6d6q N 13 3.45 URS0000D77950_32630 29906447 32630 agcaccguaaaga ............. ............. Human nuclear exosome-MTR4 RNA complex - overall reconstruction; RNA (5'-R(*AP*GP*CP*AP*CP*CP*GP*UP*AP*AP*AP*GP*AP*CP*GP*C)-3') 6d6q O 48 3.45 URS0000D77927_32630 29906447 32630 tctttacggtgctcaccacaccacacacaccacaccacacaaaaaaaa ................................................ ................................................ Human nuclear exosome-MTR4 RNA complex - overall reconstruction; DNA/RNA (62-MER) 6d6r N 13 3.45 URS0000D77950_32630 29906447 32630 agcaccguaaaga ............. ............. Human nuclear exosome-MTR4 RNA complex - composite map after focused reconstruction; RNA (5'-R(*AP*GP*CP*AP*CP*CP*GP*UP*AP*AP*AP*GP*AP*CP*GP*C)-3') 6d6r O 48 3.45 URS0000D77927_32630 29906447 32630 tctttacggtgctcaccacaccacacacaccacaccacacaaaaaaaa ................................................ ................................................ Human nuclear exosome-MTR4 RNA complex - composite map after focused reconstruction; DNA/RNA (62-MER) 6d90 5 3594 3.2 RF02540,RF02543 URS0000D56C2E_9986 29856316 0003735 0005840 9986 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggaaauguggcguacggaagacccacuccccggcgccggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugccggcggggcggaucucccgcucccgucggcgggggaccgccccccggccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcccgggggccccggguguuacagcccgccccggcagcagcagcucgccgaaucccggggccgagggagcgagacccgugcgccgcgcucuccccccucgggggggccgggccaccccucccacggcgcgaccgcuggggcggacuguccagugcgccccgggcgggucgcgccgucgggcccggggggccacgcgucccccgcgagcgcacggggucggcggcgaugucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcuacgaaagccgccguggcgcaaugaaggugaaggccggcgccgccggccgaggugggaucccgaggccuuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcgaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccaaaguuucccucaggauagcuggcgcucuccgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcugguguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggaugguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgcuggcagucggcagagcgagaaagagaguggcgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucagccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcuggcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacaugagagguguagaauaagugggaggcccgggccgccggugaauaccacuacucugaucguuuuuucacugacccggugaggcgggggggcgagccgggcucucgcuucuggcgccaagcgcccggccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauagcgccggagccucgguuggccucggauagccggucccccgccgggguccggugcggagagcccuucgucccgggaaacggggcggccggaaagggggccgcccucucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcugcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<....<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>....<<<<<<<<<....<<<<<<<<..<<<<<<<.....<<<<......>>>>.....((......<<<.....))>>>.....>>>>>>>...>>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..(((((.>>>>>..>>>..................................<<....>>...............<<<......>>>..................................<<<<<<<<..<<<.<....<<<<<<<<.<<<.....<<<<<<<<<....<<<<<<<.<<<<<.<<<<<<<.<<<<<<<<<......>>>>>>>>>>>>>>>>>>>>>>>>>...>>>..>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<.<<<<<<<<<<<<<<<...<<..<<<..<..<<<......<<<<<<<<.>>>>>>>>.......>>>..>..>>>.........>>>>>>..>>>>>>>>>>>............{............<...<<<<<<..>>>>>>....<<<..<<<.<<<<<<<<<<<<<<<<<<<<<<<.<<<<..>>>>.>>>>>>.>>>.>>>>>>>>>>>.>>>...>>>>>.>................>.........>>.>>>>>....>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<.....>>>>.....>>>...<<....>>...<<<<<<.....>>>>>>..<<<<<...<<<..<<<...(((.[[.>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<<....<<<....<<<..<.<<<..<<<<.<.........>.>>>>>>>.>..>>>..>.>>....>>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>>>>>>.>>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<........}...........]].)))............>>>>>>>>>....>>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<<....<<.....<<<<<.........>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<.<<.....>>.>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<...<<<<<<<....>>>>>>>...<<<....>>>......<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..[[[..>>>>>>.....<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>......<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>.............>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<.<<<<<<<<<<...>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<....<<<<......>>>.>...>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>...>>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<..<<<<<<<<<<...<<<...........<<<.<..<<<<..>>>>...........>.>>>..>>>....>>>>>>>>>>...<<<<<.....<<<<..<<...<<<>>.>..>>..............<<<<<<<<<..>>>>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))]......<<<<<<..<<<...))))).>>>>>>>>>..........>>>>..>>>>>>.......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.........<<<.<<<<<<..<.<.<<<<<......>>>>>.>...>.<<<.........>>>.....>>>>>..>...>>>.......<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<.]]]..>>>>..>>.>>...>>>>...>>>><<<<....<<<<<...........>>>>>....>>>>.>>>...>.>>>>>>.<<<<<<<..<<<<....<<<........<<<<<..<<<<<.>>>>>.>>>>>.......>>>...<<<..<<<<....<<.<<<<<<........>>>>>>..>>...>>>>..>>>..............>>>>..>.>>>>>>..<<<<.<.............>....<<.<<<<<<<.<<.....<<<<.<..<<<<<.>>>>>..>>>>>....>>....>>>>.>>>.>>..>>>.>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..((((((((((.......))))).))))....))))....(((((((((....(((.((((.((((.((((..({((((......)))))....[[(...).(((....}]])))...).))).)))..))))).)))...)))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..(((......)))............).....................((((((((..(((..(....(((((.(.(((.....((((((.((....(((((((.(((((.((((((..((((((((........)))))))).)))))))))))))))...)))..)).))))))......))).).).))))....(((((((((((((((((((((((...((..(((.(...(((......((((((((.)))))))).......)))..)..))).........))))))..)))))))))))......(.....{.)........(.(.(.((((((()))))))...(.((...((.(((((((((((((((((.(((((.((((..)))).)))))..))).))))))))))).)))...)).)).)..............).)..).....))).)))))...).)))...)))))))).[((((........))))((((((....(.(((((((((((..(((..(((((.....))))..)..)))...((....))...((((((.....))))))..(((((...(((..(((...[[[.[[[)))..)))....))))).((.((((((.((((......))))))))))..))....))))))))))).)..((.(...((((((.....(((((((((..(((....(((((((....)))))))....<)))...(((..((.((.......A)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((.(((...(((.(((.((((....(((....(((..(.(((...((.((..........)))).))).)..)))..)).)....)))).)....((((((((.(......))))))))).....)))))))).)))..))..((((.(((((.....))))).))))....((.(.....)))....((((((...((([[[...(.(.(((((......(..........((..((((((((.(.......(((((..((....(.........)....))......(..............).)))))...).)))))))).))..........]]].)....))))))))))...)))))).((((((.(((........}.........].]].]]]............)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....(((((.........))))).(((.....((((..((...((((((...((.....)).)))))).....[(((.((...((....(((....)))..........(..((((...((...))...)))).)......))....))...(((((........)))))].((((....(((((...((.((((....)))).))..((((....)))...(...((((((...(((((((((((((((((((((((...{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((.)))))..)))))).))............(((((((((.>.((.........))...((((((.....((((.....)))).......)))))).].(((.(((..((((((.(...(......((((....))))......).)))))..)))))(((((.........)))))........((..........(.(((.......))).)..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..((((..(.(((((((.(((((((((((..(((........[...(((...((((())))).........]..)))...)))..).))))))))))...(((((.....((((..(....((()).)...)...............(((.(.((())).).)))...))))..)))))....))))))).)...))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(.(((.(((((....{..)))).)))))(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(...(((((......))))).....).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a.))..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.((((((.}}...))))..)).))...))))...))))..((....((((.............))))....))...)))...).))))))..(((.(...((((....(((.........((((...((((.))))..))))........)))....((..(((........(((..............)))........)))..))...............))))....).)))..(((((.(..(.......)..)....((.(((((((.((.....((((.(..(((((.)))))..)))))....))....)))).))).))..))))).. Mammalian 80S ribosome with a double translocated CrPV-IRES, P-site tRNA and eRF1.; 28S rRNA 6d90 7 119 3.2 RF00001 URS000064027A_9986 29856316 0003735 0005840 9986 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcu <<<<<<<<.....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<......<.<<..<<....>>.>>.>.....>>>>>>>.>>>>>>>>. (((((((((....((((((((.....(.((((...(....)...))))...)....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))). Mammalian 80S ribosome with a double translocated CrPV-IRES, P-site tRNA and eRF1.; 5S rRNA 6d90 8 151 3.2 RF00002 URS0000D56C3A_9986 29856316 0003735 0005840 9986 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcagguugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<.<......>>>.....(.<<<.......>........>>>..)...>>>....<<<..>>><<<<<<<<<.....>>>>>>>>>.................... .........................................((((...[[.......).....(.(((......]]........)))..)...)))....((....))((((((.(.......).)))))).................... Mammalian 80S ribosome with a double translocated CrPV-IRES, P-site tRNA and eRF1.; 5.8S rRNA 6d90 2 1697 3.2 RF01960,RF01959,RF00177 URS0000D56C41_9986 29856316 0003735 0005840 9986 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucgacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgcccggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcggccguccccugcucggcgccggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgaccccggucggcguaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggugcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<....<<....<<<<.........<<.....<<.<<.......>>.>>......>>.........<<<<...<<<<<<....>>>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<<.>>>>>>>>..>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....<<<.<<<<..<<<....>>>...>>>>..>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<.....<<.<<<..>>>.>>....<<<<.<<..>>>>>>.....<<<<<<.<.......<<...<.......>.<<<<.>>>>...>>......>.>>>..>>>..........<<.<<<<<<<...............>>>>>>>.>>......>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>.>.>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<.......<<........>>..........<<<<<......<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<......>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<..>>>>.>>>>>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.......>>>>>....>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<.<<<<<<<<<..>>>>>>>>>...>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((..(.....((....((..........))...))[.)......(((.......(((.(.(..(.....(((.....((...((.....((..((.....))..))......))......)).(.((...(((((......)))))...)).)((..(((((...(......)..)))))......)).(.((((.(((...))))))))...)))....)).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).))...((....)).....)))))).).....(.(((...((((.]...))).))))).)...)).).....((((.(((...(......)....))).).)))....(.((..(...........)..))......)..((((([[......((((.....((..]])).......)))).)))))..)))))).)))..[......(.([[...(.(.((...(((.......((...((()))...))...((((.(.().))))).....((((((.(.......((...(.......)..(((.)))....))......).)))..)))........(.((.(...((.................))...).)).).........(((..(...(...(.((..((..((((((((...((........))......))))))))..)).......((....))...)).)..)...)...))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.(((((....))))))))))).)..)))...((..]]))...))...].))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((......(((((.....(..((..(..........)..))....).)))))...((.(((.....((((((.(..(((.(((((....)))..(.(........))...)).)))....(((...(...((((...(((((((((((..)))).)))))))...))))..).....(((((.....)))))........))).)..))).))).......))))).......)))))...)).)))).))).(...((.((.........(.......(((.((((....)))).)))....)..........)).))......(.....(((((..........))))).....)..)..))))).....((((((((.......))))))))......))...)))))))))).))....(..(..(..((((..(..(.((((((((.(((..((((.((...((.((.(((((((((..)))))))))...)).))...)).))))..))).)))))))))..)..))))...)..)...).....(((((((((....)))))))))}........ Mammalian 80S ribosome with a double translocated CrPV-IRES, P-site tRNA and eRF1.; 18S rRNA 6d90 3 87 3.2 RF00005 URS00004630EA_562 29856316 0030533 0006412 562 gccgaggugguggaauugguagacacgcuaccuugaggugguagugcccaauagggcuuacggguucaagucccguccucgguacca <<<<<<<..<<<...........>>><<<<<<.......>>>>>>..<.......>...<<<<<.......>>>>>>>>>>>>.... .((((((..(((......[....))).(((((.......))))).(.((.....)))..(((((..]....)))))))))))..... Mammalian 80S ribosome with a double translocated CrPV-IRES, P-site tRNA and eRF1.; P-tRNA 6d90 4 194 3.2 RF00458 URS0000D56C4A_12136 29856316 0043022 12136 aaaaaugugaucuugcuuguaaauacaauuuugagagguuaauaaauuacaaguagugcuauuuuuguauuuagguuagcuauuuagcuuuacguuccaggaugccuaguggcagccccacaauauccaggaagcccucucugcgguuuuucagauuagguagucgaaaaaccuaagaaauuuaccucucuagu ....<...........<<<<<.........................>.>>>>.........>..........<<<<.<<<<....>>>>.....((((.((((>>>>.<<<<.....>>>>...)))).))))................<<<.<<<......>>>>>>.......................... ................(...(..(...................)..).....)...................[[[....((....)).......((((.((.(.]]]..(((.....)))....).)).))))............((..(((.((........)))))..))...................... Mammalian 80S ribosome with a double translocated CrPV-IRES, P-site tRNA and eRF1.; CrPV-IRES 6d9j 5 3594 3.2 RF02540,RF02543 URS0000D56C2E_9986 29856316 0003735 0005840 9986 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggaaauguggcguacggaagacccacuccccggcgccggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugccggcggggcggaucucccgcucccgucggcgggggaccgccccccggccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcccgggggccccggguguuacagcccgccccggcagcagcagcucgccgaaucccggggccgagggagcgagacccgugcgccgcgcucuccccccucgggggggccgggccaccccucccacggcgcgaccgcuggggcggacuguccagugcgccccgggcgggucgcgccgucgggcccggggggccacgcgucccccgcgagcgcacggggucggcggcgaugucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcuacgaaagccgccguggcgcaaugaaggugaaggccggcgccgccggccgaggugggaucccgaggccuuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcgaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccaaaguuucccucaggauagcuggcgcucuccgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcugguguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggaugguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgcuggcagucggcagagcgagaaagagaguggcgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucagccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcuggcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacaugagagguguagaauaagugggaggcccgggccgccggugaauaccacuacucugaucguuuuuucacugacccggugaggcgggggggcgagccgggcucucgcuucuggcgccaagcgcccggccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauagcgccggagccucgguuggccucggauagccggucccccgccgggguccggugcggagagcccuucgucccgggaaacggggcggccggaaagggggccgcccucucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcugcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...[[[....<<<...<<.<<<<<<<.....>>>>>>..>>>.....>>>....<<<<<<<<<....<<<<<<<<..<<<<<<<.....<<<<......>>>>.....((......<<<.....))>>>.....>>>>>>>...>>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<.<....<<<<<<<<.<<<.....<<<<<<<<<....<<<<<<<.<<<<<.<<<<<<<.<<<<<<<<<......>>>>>>>>>>>>>>>>>>>>>>>>>...>>>..>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<<<<<<<<<<<<.<<<<...<<..<<<.<...<<<......<<<<<<<<.>>>>>>>>.......>>>..>..>>>.........>>>>>>...>>>>>>>>>>.........................<...<<<<<<..>>>>>>....<<<...<<.<<<<<<<<<<<<<<<<<<<<<<<.<<<<..>>>>.>>>>>>.>>>.>>>>>>>>>>>.>>>...>>.>>.>................>........>>>.>>>>>....>>>>...>>>>>>>>..<<<<........>>>><<<<<<...<<<<<<<<<<<<<<..<<<...<<<<.....>>>>.....>>>...<<....>>...<<<<<<.....>>>>>>..<<<<<...<<<..<<<....[[.[..>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>>.<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<<<...<<<....<<<....<<<..<<<<.<.........>.>>>>>>>....>>>..>>.>...>>>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>>>>>>.>>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<.....................].]].............>>>>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<......>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<..<.<<<....>>>>.........<<.<<<<<..<.....>..>>>>>>>......>>....>>...<<<<<........>>>>>))<<<<....<<<<<...<<<<<<<....>>>>>>>...<<<....>>>......<<<<<<<...<<<<<<<<<<<<<<<<<<<<<<<.......>>>>>>.....<<<<.<<<<.<<<<.....<<.......>>.....>>>>>>>>..>>>>......<<<<<<<.......>>>>>>>>>>>.>.>>>>>>>>>>>>.........>>>>>>>.............>>.>>>.>>>>>>>>..>>.....<<......>>.>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<..<<...............<<<<<...............>>>>><<.<<<<<<<<<<<.>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<..<<<....<<<<<....>>>>.>...>>>>>>>>..>>>>><<<<<.........>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>..>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{.[[[[..<<<<..<<<<<<<<..<<<<<<<<<<<<.<<<<..........<<<.<..<<<<..>>>>...........>.>>>.>>>>.>>.>>>>>>>>>>...<<<<<.....<<<<..<<.<<<<<>.>>>>>>..............<<<<<<<<<..>>>>>>>>>..>>>>..>>>>>.....>>>>>>>>...>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..(((..>>>>>>.)))))))))..........]]]]...}]]]].......<<..<..<<<<<<...<<.......>>...>>>>>>....>.>.>.........<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.......<<<<<<<....>>>.>>>>....}}..}}}.]]]]].....<.<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<.....<.<<<<<<<....>>>>>..>>.>....>>>>...>>>><<<<....<<<<<...........>>>>>....>>>>.>>>...>.>>>>.>.<<<<<<...<<<<....<<<........<<<<<..<<<<<.>>>>>.>>>>>.......>>>...<<<..<<<<....<<.<<<<<<........>>>>>>..>>...>>>>..>>>..............>>>>....>>>>>>.<<<<<.<.............>....<<.<<<<<<<.<<.....<<<<....<<<<<.>>>>>...>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...(((..(((.((((.((......)))))..)))....))))....(((((((((....((((((((.(((((((.(..({((((......)))))....[[(...).(((....}]])))...)..))))))..)))))))))...)))))))))..)....(((((((........))))))).....((((...[[[[[[.))))..)))..................................((....))............(..((((....))))............).....................(((.((((..(((..(...((((((((.(((.....(((((((((.....((((((.(((((.(((((((.((((((((.(.()..)))))))))))))))))))))))))...))...)))))))))......))).))).)))))....(((.(((.((((((((((((((...((....(.(...((........(((((((.))))))).........))..)..)...........))))))..)))))))))).......(.....{.)........(.(.(.(((((....)))))...(.((..(.(.((((((((((((((((.((((((...((..))...))))))..)).))))))))))).)))....)))).)..............).)..).....)))..)))....).)))...)))).))).[((((........))))((((((....(((((((((((((..(((..(((((.....))))..)..)))...((....))...((((((.....))))))..(((((...(((..(((.......[.[)))..)))....))))).(((((((((.((((......))))))))))).))....)))))))))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)<)))...(((..((.((........)))).)))....))))))))).(..(.......)....)..))))))......).))..((((((....(.(((....))).)((.(((((((...(((.((((((((....(.(....(((..(.(((..((((.(.(.....)..)))))))).)..)))..)..)....))))))...((.((((((.(......))))))).))....))))))))))))..))..((((.((.((.....)).)).))))....(((......)))...(((((((...((([[[.....(.(((((......(..........(((.((((((((((.......((((..(((...((.........))...))).....(...((......)).)..))))...)))))))))))))..........]]].)....)))))).)))...)))))))((((((.(((........}...........]]................)))))))))....)))))).(.((((((((.((.......(((.((.(....).)))))....))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).)))))).....[(((.((...((....(((....)))..........((.((((...((...))...))))))......))....))...(((((........)))))].((((....(.((....((.((((....)))).))...(((....))).......((((((...(((((((.(((((.(((((((((...{{..))))))....(..((.((....(((.....(.(......)).....)))...))..))..).....((((((((....).))))))))))..).)))).))))))).........))))))...............).).).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....((((((..((..(....(.......(((((.....([..).....)))))((..((((((((((.)))))..)))))..))............(((((((((.>.((.........))....((.(((....((((.....))))......))).))..].(.(.(((..((((((.(..(.......((((....)))).......))))))..)))))(.(((.........))).)........((...........((((.......))))...)..)....).)....)).))))))).)..)))..))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(.(((.(.((((.(((........[..((((...((.(()).)).........]..))))..))).)).)).).)))..)..((((......((((..((.((((().))))))..............(((((((((())))))))))..))))...)))).....))))))))..)))))..(((......[)).).(((((..........]))))).([.(...(.(((((...(((.((.......)).))).....((]..[[[))....))))).).(.(((.(((((....{..)))).)))))((......))..)]]].......((((((...((..]]]]]].)).))))))....)}....))))..)))))).......((.(...(.((((...((.......))...)))).)....).).)........((((.((.(((..(.(.(((.(......).)))...).).(((.........))).....))).)..)...))).).....(((((((....))).))))....))..))).))))).....((.(((....(((..(.(((((......(....).....))))).)((((....((((....(..(((((((}}..)))))..))..)...))))...)))).(((....((((.............))))....)))..))).....))).)).(((...(..((((....(((.........((((...(((...)))..))))........)))...(((..(((.....(..((((((........))))))...)....)))..)))..............))))..)....))).(((((....(.......).......((.(((((((.((.....((((.(..(((((.)))))..)))))....))....)))).))).))..))))).. Mammalian 80S ribosome with a double translocated CrPV-IRES, P-sitetRNA and eRF1.; 28S rRNA 6d9j 7 119 3.2 RF00001 URS000064027A_9986 29856316 0003735 0005840 9986 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>. ((((((.((....((((((((......(((((...(....)...))))..).....)))))).))((((((......((.((..((....)).)).)).....)))))))).)))))). Mammalian 80S ribosome with a double translocated CrPV-IRES, P-sitetRNA and eRF1.; 5S rRNA 6d9j 8 151 3.2 RF00002 URS0000D56C3A_9986 29856316 0003735 0005840 9986 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcagguugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<<<<....>>>>.....<.<<<......>>........>>>..>...>>>....<<....>><<<<<<<<.......>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((....(.]].)......)))..)...)))....((....))((((((((.......)))))))).................... Mammalian 80S ribosome with a double translocated CrPV-IRES, P-sitetRNA and eRF1.; 5.8S rRNA 6d9j 2 1697 3.2 RF01960,RF01959,RF00177 URS0000D56C41_9986 29856316 0003735 0005840 9986 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucgacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgcccggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcggccguccccugcucggcgccggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgaccccggucggcguaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggugcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<.........<<<.<<<...<....<<....<<..........>>...>>.>.......<<........<<<.......<....<<<<<........<<.....<<..<.......>..>>......>>.........<<<<...<<<<<<....>>>>.>>..>>>><<..<<<<<.............>>>>>......>>...<<<..<<<<.>>>>.>>>.>>.>>>....>....>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>...<<....>>.....>>>>>>.........<<<....<<<.....>>>..>>>......>>.>.....<<<<<<.<<.<<<....>>>..>>.>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>...........<((.....<.<<...<<<.<<....<<<.<<<..>>>.>>>.<<<<<<.<<..>>>>>>.>>..<<<.<<.<.......<<...<.......>.<<<<.>>>>...>>......>.>>...>>>........<.<<.<<<<<<<...............>>>>>>>.>>.>....>>....<<<<<<......<<<<..<<<.<<<<<<<<...<<<......>>>......>>>>>>>>.>>>.......<<....>>...>>>>.....>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>....<<......<<<......>>>....>>...)))).]..<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<........>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<..>>>>.>>>>>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<..<<<....>>>..>>>....>.........>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>..........<<.<..<<<<.<<....<<<<<<<<.<<<...<<<.<<...<<<<<.<<<<<<<<....>>>>>>>>...>>>>>...>>.>>>...>>>.>>>>>>>>...>>.>>>>...>.>>.........<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..)))).((.((((((...(.((...(.....(((.(((..(.....((....((..........))...))[.).......((.......(((...(..(.....(((.....((...((.....((..(.......)..))......))......)).((((....(.(((....)))..)...))))((..((.((...(......)..)).))......)).(.((...((.(..)))..)))...)))....))...))).(((....(((....(((((((.........))))))))))......)))...(((.(((......)))....)))))..((.(((..........))).))...((....)).....)))))).).....(.(((...((((.]...))).))))).....)).).....(((.((((..(((....)))...))))..)))....(.((..(...........)..))......)...(((([[......((((.....((..]])).......)))).))))...)))))).))...[........([[...(.(.((...(.(.((....(((...(())...))).((((((.((())))))).))..(((.((.(.......((..(.........).((...))....))......).))...)))........(.(..((((((.................))))))..).)....))...(((..(.(.(...((((..((..(((((((....((........)).......)))))))..)).......((....))...))))..)..))...))..)).)...)).)....((((((....(...((((.........))))...).))))))......{....((.((.(((....((((((.(.(((....))).)))))))....)))....((.]]))...))...].)).))....((.......(.(....).).....))....]]].](.(((.((((.((..((..(((((..(((.((((((.......(........)...........(((((..(...(((((.....(..((..((........))..))....).)))))...((.(((...(.((((((......(.(((.(.....))..(.((......)))...)).)......(((...(.....((..((((((((((((..)))).))))))))..))....).....(((((.....)))))........)))....))).))).....).))))).....).)))))...)).)))).))).(...((.(((........(........((..(((....)))..)).....).........))).))......(.....(((((..........))))).....)..)..))))).....((((((((.......))))))))......))...)).)))))))..)..(....((.(..((((.((..(.(((((((..(((..(.((.((...((((((.((((..((..).).))).).).)))))...)).)).)..)))..))))))))..)).))))...).))......)..(((((((((....)))))))))}........ Mammalian 80S ribosome with a double translocated CrPV-IRES, P-sitetRNA and eRF1.; 18S rRNA 6d9j 3 87 3.2 RF00005 URS00004630EA_562 29856316 0030533 0006412 562 gccgaggugguggaauugguagacacgcuaccuugaggugguagugcccaauagggcuuacggguucaagucccguccucgguacca <<<<<<<..<<<...........>>><<<<<<.......>>>>>><<<......>>>..<<<<<.......>>>>>>>>>>>>.... .((((((...((...........))..(((((.......))))).((.(.....)))..(((((.......)))))))))))..... Mammalian 80S ribosome with a double translocated CrPV-IRES, P-sitetRNA and eRF1.; P-site tRNA 6d9j 4 190 3.2 RF00458 URS0000D56C35_12136 29856316 0043022 12136 aaaaaugugaucuugcuuguaaauacaauuuugagagguuaauaaauuacaaguagugcuauuuuuguauuuagguuagcuauuuagcuuuacguuccaggaugccuaguggcagccccacaauauccaggaagcccucucugcgguuuuucagauuagguagucgaaaaaccuaagaaauuuaccucuu <<<............<<<<<<.<<........((((.........>>>>>>>>..........>>>......<<<<..<<<....>>>......((((..((.>>>>..<<<.....>>>.....))..))))....)))).......<<.........((......>>..............))..... ((.............((((((............[..[..........))))))...........))......[[.....((....)).......((((.((.(..]]...((.....)).....).)).))))...]..]......(((...................)))................... Mammalian 80S ribosome with a double translocated CrPV-IRES, P-sitetRNA and eRF1.; CrPV IRES 6ddd 1 2646 3.1 RF02540,RF02541,RF00002 URS00001C3329_1280 30667174 0003735 0005840 1280 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<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<<......<<<<<<.[.[.((.>>>.....<<<<<<<..<<<)).].].>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<<<<<<<<.........>>>>>>>.>>.>>....<<<<<......<<....>>.......>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..<<<....<<..>>......<<<<<<<<<........<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>........>>>>>..>>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..>>>......>>.>>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<..<<<<......>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<.<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>.>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<..>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<...<<<<<<<<<.....<<<...<<<<<<<...>>>>>>>..>>.>.....>>>>.>>>>>..>>>>>>>.>>..<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<.<<<..>>>.>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<.....>>>>>>....>>>>>>..<<<<<<<.<<......<<<<<.<<....>>.>>>>>...>>.>>>>>>>........>>>>>><......<<....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<.......<<...<<<<....<<<<..<<<..<<<<<.<.<<<...[.[...>>>.>.<....<<<<...<<..>>...>>>>.....>....<..>....>>>>>...>>>...>>>>.........>>>>..>>......>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<....>.>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<....<....>.....>>>>><<<<<<<.<<<<....>>>>.>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<..<<...<<<<<<.<<....>>..>>>>>>...>>..>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<....>>>>....<<.<<<<<<.....>>>>>>>>.....>>>>>>>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<..>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]......<<<<<<.<<<..>>>>..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.].]>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<..>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>. 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Structure of the 50S ribosomal subunit from Methicillin Resistant Staphylococcus aureus in complex with the oxazolidinone antibiotic LZD-5; 23S rRNA 6ddd 2 104 3.1 RF00001 URS0000062A7E_1280 30667174 0003735 0005840 1280 gugacuauagcaaggaggucacaccuguucccaugccgaacacagaaguuaagcuccuuagcgucgaugguagucgaacuuacguuccgcuagaguagaacguu <........<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<...<....<..<........>..>.....>..>......> (........((((((((.....((((((...(.....)...))))..))....)))))).))..........(..............)...............) Structure of the 50S ribosomal subunit from Methicillin Resistant Staphylococcus aureus in complex with the oxazolidinone antibiotic LZD-5; 5S rRNA 6ddg 1 2646 3.1 RF02540,RF02541,RF00002 URS00001C3329_1280 30667174 0003735 0005840 1280 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<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<<<<<<<<.........>>>>>>>.>>.>>....<<<<<......<<....>>.......>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..(((....<<..>>......<<<<<<<<<......<.<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>..>.....>>>>>..>>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<....>>>>..................>>>>>>>>>>>.......<<<<..<<<<......>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<.<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>.>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<..>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<...<<<<<<<<<.....<<<...<<<<<<<...>>>>>>>..>>.>.....>>>>.>>>>>..>>>>>>>.>>..<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<.<<<..>>>.>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<.....>>>>>>....>>>>>><.<<<<<<<.<<......<<<<<.<<....>>.>>>>>...>>.>>>>>>>..>.....>>>>>><......<<....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<.......<<...<<<<....<<<<..<<<..<<<<<.<.<<......{....>>.>.<....<<<<...<<..>>...>>>>.....>....<..>....>>>>>...>>>...>>>>.........>>>.>.>>......>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<....>.>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<....<<..>>.....>>>>><<<<<<<.<<<<....>>>>.>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<..<<...<<<<<<.<<....>>..>>>>>>...>>..>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<<.<<<<....>>>>....<<.<<<<<<.....>>>>>>>>.....>>>>>>>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<..>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.}..>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<..>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>. (((((......((((((((((.....(((..((((((((.((((......((((((.[...[[[)))...].((((((...(((]]...].)))......))))))...)))....(((....)))(((((((......))))))).(((((.((...........)).))).)).))....(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...((()))....{.(((((((.(.........((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))).........).)))..)))))....(((((((...[.......)))))))....}.(((((].[[[[)))))..)))......))..)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((..((((..[...))))..)))).A.(.(........).).((((((....(((((((.(((((..(((...(((.....)))...)))...((....))..((((.....)))).....))))).)))))))..((.(...((((((.....((((((((((.((((...((((((..))))))...).)))...(((.(((((.......<))))))))..).))))))))).(.(((....[)))...).]))))))......).))..((((((....(((((....)))))(((((((((...((.((((((.....(((...((((((.(.).))))))..)).).....)))).)).))..))))))).))..((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((.((....)).)))).))...........]]].)...))))))))))...)))))))((((((.....))))))....))))))(.(((((((.((......(((((.((....))])))))...)).)))))))..).....))))))(......((....((((((.......))))))((((....(((...((...((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((.......((...((((....((((..(((..(((((...(.......{.....)....(....(((...((()))...))).....).....(..)....)))))...)))...))))(..).....))))..))......)))))))))))..)).....((......))..))).(((.......)))..))))..((((....((((((((.((..(....(.......(((((....(.[..).....)))))(((((.....((....)).....)))))(...).......((((((.((...((.........))...(((((((.....(((....))).......))))))).]((((..((..(((((((..(((...((...(((((..((....))...)))))...))...))))))))..)))).(((((.........)))))........((..........(((((.......)))))..)..)....))))...))..)))))).)..))).)))))))).)))))).....)).[..(((((.....a].)))))..((((((((.(((..(......((((.((((((..(((((.(((((((((.((((....))))....((.((((((.....)))))))).....)))))))))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((..)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....((.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..))....(((((.(....).).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}..))))))..)))))...)))).)))))...(((....((((.............))))....))).))))..]....))))))).(((..)))....(((((((((.......)))))....((.(((((.(((....(((((....)))))...)))..)))))..))...))))....))))). Structure of the 50S ribosomal subunit from Methicillin Resistant Staphylococcus aureus in complex with the oxazolidinone antibiotic LZD-6; 23S rRNA 6ddg 2 104 3.1 RF00001 URS0000062A7E_1280 30667174 0003735 0005840 1280 gugacuauagcaaggaggucacaccuguucccaugccgaacacagaaguuaagcuccuuagcgucgaugguagucgaacuuacguuccgcuagaguagaacguu <........<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<......<<<..<........>..>..>>....>......> (........((((((((.....((((((...(.....)...))))..))....)))))).))..........(..............)...............) Structure of the 50S ribosomal subunit from Methicillin Resistant Staphylococcus aureus in complex with the oxazolidinone antibiotic LZD-6; 5S rRNA 6dn1 X 54 3.03 RF00050 URS000080E295_851 30107111 0010181 851 ggaucuucggggcagggugaaauucccgaccggugguauaguccacgaauccau ..............<<<.......>>>.....<<<<......>>>>........ ..............(((.......))).....((((......))))........ CRYSTAL STRUCTURE OF THE FMN RIBOSWITCH BOUND TO BRX1151 SPLIT RNA; RNA RIBOSWITCH 6dn1 Z 57 3.03 RF00050 URS000080E334_851 30107111 0010181 851 ggauugauuuggugaaauuccaaaaccgacaguagagucuggaugagagaagauucg .......<<<<<.......>>>>>.....<<<......>>>................ .......(((((.......))))).....(((......)))................ CRYSTAL STRUCTURE OF THE FMN RIBOSWITCH BOUND TO BRX1151 SPLIT RNA; RNA (57-MER) 6dn2 X 53 2.88 RF00050 URS000080DF4D_851 30107111 0010181 851 ggaucuucggggcagggugaaauucccgaccggugguauaguccacgaaagcu ..............<<<.......>>>.....<<<<......>>>>....... ..............(((.......))).....((((......))))....... CRYSTAL STRUCTURE OF THE FMN RIBOSWITCH BOUND TO BRX1354 SPLIT RNA; RNA RIBOSWITCH 6dn2 Y 56 2.88 RF00050 URS000080E20B_851 30107111 0010181 851 gcuuugauuuggugaaauuccaaaaccgacaguagagucuggaugagagaagauuc .......<<<<<.......>>>>>.....<<<......>>>............... .......(((((.......))))).....(((......)))............... CRYSTAL STRUCTURE OF THE FMN RIBOSWITCH BOUND TO BRX1354 SPLIT RNA; RNA (56-MER) 6dn3 X 54 2.8 RF00050 URS000080DF4D_851 30107111 0010181 851 ggaucuucggggcagggugaaauucccgaccggugguauaguccacgaaagcuu ..............<<<.......>>>.....<<<<......>>>>........ ..............(((.......))).....((((......))))........ CRYSTAL STRUCTURE OF THE FMN RIBOSWITCH BOUND TO BRX1555 SPLIT RNA; RNA RIBOSWITCH 6dn3 Y 56 2.8 RF00050 URS000080E20B_851 30107111 0010181 851 gcuuugauuuggugaaauuccaaaaccgacaguagagucuggaugagagaagauuc .......<<<<<.......>>>>>.....<<<......>>>............... .......(((((.......))))).....(((......)))............... CRYSTAL STRUCTURE OF THE FMN RIBOSWITCH BOUND TO BRX1555 SPLIT RNA; RNA (56-MER) 6dnc A 1539 3.7 RF00177,RF01959,RF01960 URS000080DDC0_562 29941456 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.....<<<<<<<<<......>>>>>>.>>>....>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<......>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<.<<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<.<<....>>>......>>>>...<.<<<<<........<<<<<<<<.......>>>>>>>>..........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>.>..........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((..(............)...)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..(......))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).......(((...(((((....)))).))))..)).))))))..((((.......(((....)))......))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((...((((((....)))))).....(....)...))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....))))))))..)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... E.coli RF1 bound to E.coli 70S ribosome in response to UAU sense A-site codon; 16S ribosomal RNA 6dnc B 2903 3.7 RF02540,RF02541 URS0000A76322_562 29941456 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugucgaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccgggagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<....<.<<<<<<<<<<<<<.<<<...<<<<........>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>..>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<<..>>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<.......>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<<..<.............>..>>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<.<<......>>.>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<.<.<<<...<<<....>>>...>>>..>>>>...<<<<........>>>>.))<<<<<<<<<<<<<...<<<<....<<<...<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>....>>.>........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<<.<<....>>..>>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<............<<<<...<<.......<<<<<<<....>>>>>>>....>>.............>>>>...>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<...<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>......>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<.)))..>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<.........>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((.......((((((((((((.(((...(((((......)))))[[......(((.....]])))...)))...))))))))))))....))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...).)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((((((.......)))).))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((.(......).))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..(((((((((((....{{{...))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((...((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.(.((............((.(...((.......((((.(......).))))....).)............).))...)).).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....((.((((....))).).))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). E.coli RF1 bound to E.coli 70S ribosome in response to UAU sense A-site codon; 23S ribosomal RNA 6dnc C 120 3.7 RF00001 URS00008116C5_562 29941456 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((.............))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). E.coli RF1 bound to E.coli 70S ribosome in response to UAU sense A-site codon; 5S ribosomal RNA 6dnc D 77 3.7 RF00005 URS000041AF00_562 29941456 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... E.coli RF1 bound to E.coli 70S ribosome in response to UAU sense A-site codon; tRNA(fMet) 6dnc KA 19 3.7 29941456 32630 aggagguaaaaauguauaa ................... ................... E.coli RF1 bound to E.coli 70S ribosome in response to UAU sense A-site codon; mRNA 6dnc LA 77 3.7 RF00005 URS000041AF00_562 29941456 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... E.coli RF1 bound to E.coli 70S ribosome in response to UAU sense A-site codon; tRNA(fMet) 6dti A 1507 3.54 RF00177,RF01959,RF01960 URS0000E60B6E_300852 31945376 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuaggaacccgggugaaagccuggggugccccggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagcaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucacuuucu ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<<.....>>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<<....>>>>>>.....>>>>>....<<<<.<<<<<....>>>>>.>>>>...<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>...<..........<......>........>......<<<<<......<..<........>....>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<.<..<<<<<<<.<..<<<......>>>.....>.>>>>>>>...>.......<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<...<<<<<<<....>>>>>>>...<<....>>....>>>>>>.<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<.<<<<<<...<.<<<<....<<<<..>>>>.>>>>.>..>>>>>>.>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.....)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(..((....))..).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..............(......)...............(((((...(......................)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((.(((((...))))).))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((.....(...((....))...).....(.....).....)))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.((((((........(((.....))).......))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((.((((((...(.((((....(((....))).)))).)..)))))).))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Structure of the Thermus thermophilus 30S ribosomal subunit complexed with an unmodifed anticodon stem loop (ASL) of Escherichia coli transfer RNA Arginine 2 (TRNAARG2) bound to an mRNA with an CGU-codon in the A-site and paromomycin; 16s rRNA 6dti X 11 3.54 URS000080E204_562 31945376 562 ggcuacgaacc <<.......>> ((.......)) Structure of the Thermus thermophilus 30S ribosomal subunit complexed with an unmodifed anticodon stem loop (ASL) of Escherichia coli transfer RNA Arginine 2 (TRNAARG2) bound to an mRNA with an CGU-codon in the A-site and paromomycin; tRNA ASL Escherichia coli Arg2 6dzi h 1511 3.46 RF00177,RF01959,RF01960 URS0000D7794D_246196 30038002 0003735 0005840 246196 uuuggagaguuugauccuggcucaggacgaacgcuggcggcgugcuuaacacaugcaagucgaacggaaaggcccuuucggggguacucgaguggcgaacgggugaguaacacgugggugaucugcccugcacuuugggauaagccugggaaacugggucuaauaccgaauacacccugcuggucgcauggccugguaggggaaagcuuuugcggugugggaugggcccgcggccuaucagcuuguugguggggugauggccuaccaaggcgacgacggguagccggccugagagggugaccggccacacugggacugagauacggcccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagcgacgccgcgugagggaugacggccuucggguuguaaaccucuuucagcacagacgaagcgcaagugacgguaugugcagaagaaggaccggccaacuacgugccagcagccgcgguaauacguaggguccgagcguuguccggaauuacugggcguaaagagcucguaggugguuugucgcguuguucgugaaaacucacagcuuaacugugggcgugcgggcgauacgggcagacuagaguacugcaggggagacuggaauuccugguguagcgguggaaugcgcagauaucaggaggaacaccgguggcgaaggcgggucucugggcaguaacugacgcugaggagcgaaagcguggggagcgaacaggauuagauacccugguaguccacgccguaaacgguggguacuagguguggguuuccuuccuugggauccgugccguagcuaacgcauuaaguaccccgccuggggaguacggccgcaaggcuaaaacucaaaggaauugacgggggcccgcacaagcggcggagcauguggauuaauucgaugcaacgcgaagaaccuuaccuggguuugacaugcacaggacgccggcagagaugucgguucccuuguggccugugugcagguggugcauggcugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuugucucauguugccagcacguuaugguggggacucgugagagacugccggggucaacucggaggaagguggggaugacgucaagucaucaugccccuuauguccagggcuucacacaugcuacaauggccgguacaaagggcugcgaugccgugagguggagcgaauccuuucaaagccggucucaguucggaucggggucugcaacucgaccccgugaagucggagucgcuaguaaucgcagaucagcaacgcugcggugaauacguucccgggccuuguacacaccgcccgucacgucaugaaagucgguaacacccgaagccgguggccuaacccuuguggagggagccgucgaaggugggaucggcgauugggacgaagucguaacaagguagccguaccggaaggugcggcuggauc ......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<..<<<<<.<....>.>>>.>>>..>>>>>......<<........<<<<<<<..<<...<<<<<<<<<<<<.....<<<<<......>>>>>......>>>>.....<<<<<<<<<<<....>>>>.>>>>>>>....<......>>>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<.......<<<....>>>......>>>>...<.<<<<<......<......>.......>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<.....<<<<<<<.....>>>>>>>...>>>>>>>..>>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<<..<<<......>>>.....>>>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<.......>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<.......<<<<<<....<<<<<<....>>>>>>..<<.....>>.>>>>>>..<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<..<....<...<<<......>>>.>.....>..>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>......>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>.....<<<<<<..........>>>>>>.......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<..<<<<....<.<<<<..<<<..<<.....>>.>>>.>>>>.>...>>>>..>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... ......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((....((.(....).))...))..)))))......(((.......(((((((..((...((((((((((((.....((((((....))))))......)))).....((((.((((((....)))).)).))))....((....))))))))))..))))))))).(((....(((..((((((((.......)))))))))))......)))..((((.(((....)))....))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(..((....))..)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.(((((..((......(((((((.....)))))))....))..)))..)))))))))..(((.(((((...((((((((....((.((((...((........))......)))).))....).......((....)).)))))))..)))))..))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((..(.(((((((.(..(.......)..).)))))))...((..]])).....).)))))))).(((......((((....))))....)))...]]].](((((.(((((((.....(((.(..((((((((((......((........))..........((((((...(...(.((((((...((((((....))))))...(.....).)))))).)).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((.(.(((.(((...((..(((......)))))....))).)))..(..(((.(.....).))).....)..).)).....).).)))...)).))))).....))))))..[)).)))))))).(...((((((.......((..((....((....))....))....))........))))))......(....(((((((........)))))))....)..)..).))).....(((((((......]...)))))))...........)))))))))).))..(.(..((.(.((((.(((..((((((..((((....(.((((..(((..(((..).)).))).)))).)...))))..))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Cryo-EM Structure of Mycobacterium smegmatis 70S C(minus) ribosome 70S-MPY complex; 16S rRNA 6dzi A 3119 3.46 RF02540,RF02541 URS0000D7793F_246196 30038002 0003735 0005840 246196 aaguguuuaagggcgcaugguggaugccuuggcacugggagccgaugaaggacguaggaggcugcgauaagccucggggagcugucaaccgagcguugauccgaggauguccgaauggggaaacccggcacgagugaugucgugucaccaggcgcugaauauauaggcgucuggggggaacgcggggaagugaaacaucucaguacccguaggaagagaaaacaaaaugugauuccgugaguaguggcgagcgaaagcggaggauggcuaaaccguaugcaugugauaccggguagggguugugugugcgggguugugggaccuaucuuuccggcucuaccuggcuggagggcagugagaaaauguugugguuagcggaaauggcuugggauggccugccguagacggugagagcccgguacgugaaaacccgacgucugucuugaugguguucccgaguagcagcgggcccguggaaucugcugugaaucugccgggaccacccgguaagccugaauacuucccagugaccgauagcggauuaguaccgugagggaauggugaaaaguaccccgggaggggagugaaagaguaccugaaaccgugcgcuuacaauccgucagagcccucgacgugucguggggugauggcgugccuuuugaagaaugagccugcgagucagggacaugucgcgagguuaacccgggugggguagccgcagcgaaagcgagucugaauagggcguauccacacaagagugugugguguagugguguguucuggacccgaagcggagugaucuacccauggccagggugaagcgcggguaagaccgcguggaggcccgaacccacuuagguugaagacugaggggaugagcuguggguaggggugaaaggccaaucaaacuccgugauagcugguucuccccgaaaugcauuuaggugcagcgucgcauguuucuugccggagguagagcuacuggauggccgaugggccccacaggguuacugacgucagccaaacuccgaaugccgguaaguccaagagugcggcagugagacggcgggggauaagcuccgugcgucgagagggaaacagcccagaucgccggcuaaggccccuaagcgugugcuaaguggaaaaggaugugcagucgcgaagacaaccaggagguuggcuuagaagcagccacccuugaaagagugcguaauagcucacuggucaagugauugugcgccgauaauguagcggggcucaagcacaccgccgaagccgcggcagccaacguguuggcuggguaggggagcguccugcauccggugaagccgccgagugaucgagugguggagggugugggagugagaaugcaggcaugaguagcgauuaggcaagugagaaccuugcccgccgaaagaccaaggguuccugggccaggccaguccgcccagggugagucgggaccuaaggcgaggccgacaggcguagucgauggacaacggguugauauucccguacccguguaugugcguccaugaugaaucagcgguacuaaccauccaaaaccaccgugaccgcaccuuucgggguguggcguugguggggcugcaugggaccuucguugguaguagucaagcgauggggugacgcaggaagguagccguaccggucagugguaauaccgggguaagccuguagggagucagauagguaaauccgucuggcauauauccugagaggugaugcauagccgagugaggcgaauucggugauccuaugcugccgagaaaagccucuagcgaggacauacacggcccguaccccaaaccaacacagguggucagguagagaauacuaaggcguacgagugaacuaugguuaaggaacucggcaaaaugcccccguaacuucgggagaagggggacccacauggcguguaagccuuuacggcccaagcgugaguggguggcacaaaccagugagaagcgacuguuuacuaaaaacacagguccgugcgaagucgcaagacgauguauacggacugacgccugcccggugcuggaagguuaagaggacccguuaacucccuuugggggugaagcggagaauuuaagccccaguaaacggcggugguaacuauaaccauccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaacgacuucucaacugucucaaccauagacucggcgaaauugcacuacgaguaaagaugcucguuacgcgcggcaggacgaaaagaccccgggaccuucacuacaacuugguauuggugcucgauacgguuuguguaggauaggugggagacugugaagcucacacgccaguguggguggagucguuguugaaauaccacucugaucguauugggccucuaaccucggaccguauauccgguucagggacagugccugguggguaguuuaacuggggcgguugccuccuaaaauguaacggaggcgcccaaagguucccucaaccuggacggcaaucagguguugaguguaagugcacaagggagcuugacugcgagacggacaugucgagcagggacgaaagucgggacuagugauccggcaccucugaguggaaggggugucgcucaacggauaaaagguaccccggggauaacaggcugaucuuccccaagaguccauaucgacgggaugguuuggcaccucgaugucggcucgucgcauccuggggcuggagcaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguuuagaacgucgugagacaguucggucucuauccgccgcgcgcgucagaagcuugaggaaaccugucccuaguacgagaggaccgggacggacgaaccucugguauaccaguugucccaccaggggcacggcuggauagccacguucggacaggauaaccgcugaaagcaucuaagcgggaaaccucuuccaagaccaggcuucucacccucuaggagggauaaggccccccgcagaccacgggauugauagaccagaccuggaagccuaguaauaggugcagggaacuggcacuaaccggccgaaaacuuac <<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))...)).>>>.....>>>>>>>...>>>....<<<....>>>.<<<<<<......>>>>>>..<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>..<<<<<<.....<<.....>>....>>>>>>...<<<....<<<<<<<<<<.........<<<<......>>>>>>>>>>......<<<<..[.[...<<<<<<..>>>>..>>>>>><<<<<<........<<<<<.<<<<.<<<.....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>.>>>>>>..]..]...>>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<<<<..>>>>.>>>>>..>>>>...<.<........>.>.<<<<<<....<<<.<<<<<<<<<<..<<<...<<<....>>>...>>>...<<....>>..<<<<.....>>>>....<<<<<<<....>>>>>>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<....<<<<<<<<.....<<<....<<<.<<<<.<....<<<<....>>>>......>>>>>.>>>..>>.>.....>>>>>>>>.......>>>>>>>.>>..<<<<<<<<<<......>>>>>>.>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<...<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>..>>...........)))......>>>>>>.>>>...>>>>>>><<<<<<<<..>>>>>>>>....>>>>>><.<<<<<<<<<<......<<<<<<<<....>>>.>>>>>...>>>>>>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<.<.<<<...<<<....>>>...>>>..>>>...<<<<<........>>>>>))<<<<<<<<<<.......<<<<...<<<<<<.......<<<<.<....<<<<<....<<<<<<<<....>>>>>>>>....>>>>>....>.>>>>......>>>>>>.....>>>>.<<...<<<<<...<<<<..<<<..<<<<..<<<<<....[[[...>>>>>.<<..<<<<...<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>...>>>>...>>...<<<......>>>.....>>>>...>>>...>>>>........>>>>.>.>>....>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<<...<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<...<<<<....<<<.....>>>....>>>>..>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<....<<<<<.<<<<<<...>>>>>>..>>>>>....>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>>>>>>>>.....>.((..<<<<<......))>>>>>..<<<<<<<<.<<<.<<......<<<<<.<<<<..<<<<<.<<<.<<<<<.<<.<<<<<<<<<<<..............<<<<...........<<<<<<<<....>>>>>>>>..................>>>.>....>>>>>>>>>>>.>>...<<<.<<<<<<......>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>...>>>>>.......<<<<...<.<<<<...<<.......>>...>>>>.>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<.]]]..>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<...>>>>>....<<<<.<<<<.......>>>>.....<<<.<<<<.<<<....<<<<<....>>>>>...>>>..>>>>..>>>...>>>>....>>>>.. 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Cryo-EM Structure of Mycobacterium smegmatis 70S C(minus) ribosome 70S-MPY complex; 23 S rRNA (3119-MER) 6dzi B 118 3.46 RF00001 URS00000ACC0A_246196 30038002 0003735 0005840 246196 guuacggcgguccauagcggcagggaaacgcccggucccaucccgaacccggaagcuaagccugccagcgccgaugauacuacccauccggguggaaaaguaggacaccgccgaacac <<<.<<<<<<<.....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<.......<<<<<<....>>>>>>.......>>..>>>>>>>>>>.. .((.(((((((.....((((((((.....((((((...(.....)...))))..))....)))))).)).((.......((((((....)))))).......))..)))))))))... Cryo-EM Structure of Mycobacterium smegmatis 70S C(minus) ribosome 70S-MPY complex; 5S RNA (118-MER) 6dzp A 3119 3.42 RF02540,RF02541 URS0000D7793F_246196 30038002 0003735 0005840 246196 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<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))...)).>>>.....>>>>>>>...>>>....<<<....>>>.<<<<<<......>>>>>>..<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<.....>>..<<<<<<.....<<.....>>....>>>>>>...<<<....<<<<<<<<<<.........<<<<......>>>>>>>>>>......<<<<..[.[...<<<<<<..>>>>..>>>>>><<<<<<........<<<<<.<<<<.<<<.....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>.>>>>>>..]..]...>>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<<<<..>>>>.>>>>>..>>>>...<.<........>.>.<<<<<<....<<<.<<<<<<<<<<..<<<...<<<....>>>...>>>...<<....>>..<<<<.....>>>>....<<<<<<<....>>>>>>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<....<<<<<<<<.....<<<....<<<.<<<<.<....<<<<....>>>>......>>>>>.>>>..>>.>.....>>>>>>>>.......>>>>>>>.>>..<<<<<<<<<<......>>>>>>.>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<...<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>..>>...........)))......>>>>>>.>>>...>>>>>>><<<<<<<<..>>>>>>>>....>>>>>><.<<<<<<<<<<......<<<<<<<<....>>>.>>>>>...>>>>>>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<.<.<<<...<<<....>>>...>>>..>>>...<<<<<........>>>>>))<<<<<<<<<<.......<<<<...<<<<<<.......<<<<.<....<<<<<....<<<<<<<<....>>>>>>>>....>>>>>....>.>>>>......>>>>>>.....>>>>.<<...<<<<<...<<<<..<<<..<<<<..<<<<<....[[[...>>>>>.<<..<<<<...<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>...>>>>...>>...<<<......>>>.....>>>>...>>>...>>>>........>>>>.>.>>....>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<<...<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<...<<<<....<<<.....>>>....>>>>..>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<....<<<<<.<<<<<<...>>>>>>..>>>>>....>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>>>>>>>>.....>.((..<<<<<......))>>>>>..<<<<<<<<.<<<.<<......<<<<<.<<<<..<<<<<.<<<.<<<<<.<<.<<<<<<<<<<<..............<<<<...........<<<<<<<<....>>>>>>>>..................>>>.>....>>>>>>>>>>>.>>...<<<.<<<<<<......>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>...>>>>>.......<<<<...<.<<<<...<<.......>>...>>>>.>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<.]]]..>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<...>>>>>....<<<<.<<<<.......>>>>.....<<<.<<<<.<<<....<<<<<....>>>>>...>>>..>>>>..>>>...>>>>....>>>>.. ((((......((((((((((.....(((..(((((((((((((......((((((.[[.[[[.))).....((((((...(((]]]..]].)))......))))))...)))....(((....)))(((((((......))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))....((([...((((((((...........[[[[.[......))))))))....(.((((.....(..((((((.]]]].].)))))).(((((........(((.(.((((.(((...(.((((......)))))[[(...).(((.....]])))...)))...))))).))).))))).....)....))))].....((((((...[.......)))))).....).(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((..(((((((((..)))).)))))..)))).<.(.(........).).((((((..(.(((.((((((((((..(((...(((....)))...)))...((....))..(((.......)))....(((((((....)))))))....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......A))))))))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))(((((((((.([.((((((((.....(((....(((.((.(....(.((((....))))..)....).)).)))..)).).....))))))))....).]))))))).))..((((((((((......)))))).))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.((([.(((.........)))..))).....(]..((......)).).)))))...)))))))))).))...........]]].)....))))))))))...)))))))((((((((..))))))))....))))))(.((((((((((......((((((((....))).)))))...))))))))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]]((((((((.(.......(((...(.(..((.......((((.((...(((((.....(..(((......)))..).....)))))...)).))))......))...)).....))).((...(((((...((((..(((..((((..(((((....{{....))))).((..(((....(((((((((((.((.....))))))))).....))))..[.)))...))...(((......))).....))))...)))...))))(..)....)))))..))....).)))))))))))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((...((((....((((..)])))....))))..))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((....((((..((.(((...))).))...))))....))...))))))))..)))))((.((.........)).))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....))[[..(((((.....>]])))))..((((((((.(((.((......((((((((((..(((((.(((.(((((.((.(((((..(((....(............((...(.......((.(............).))....).............))...)....)))..))))).))...(((.((((((......)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.(.((((...((.......))...)))).)...).)).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..a.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..(((((...)))))....((((.((((.......)))).....(((.((((.(((....(((((....)))))...)))..))))..)))...))))....)))).. Cryo-EM Structure of Mycobacterium smegmatis C(minus) 50S ribosomal subunit; 23S rRNA 6dzp B 118 3.42 RF00001 URS00000ACC0A_246196 30038002 0003735 0005840 246196 guuacggcgguccauagcggcagggaaacgcccggucccaucccgaacccggaagcuaagccugccagcgccgaugauacuacccauccggguggaaaaguaggacaccgccgaacac <<<.<<<<<<<.....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<.......<<<<<<....>>>>>>.......>>..>>>>>>>>>>.. .((.(((((((.....((((((((.....((((((...(.....)...))))..))....)))))).)).((.......((((((....)))))).......))..)))))))))... Cryo-EM Structure of Mycobacterium smegmatis C(minus) 50S ribosomal subunit; 5S rRNA 6e7l A 22 2.59 URS0000EEACE7_32630 31584014 32630 gggcugcacuucggugcugccc ...................... ...................... Structure of a dimerized UUCG motif; RNA (5'-R(*GP*GP*GP*CP*UP*GP*CP*AP*CP*UP*UP*CP*GP*GP*UP*GP*CP*UP*GP*CP*CP*C)-3') 6e80 A 35 2.901 URS0000BC4664_32630 31178406 32630 gcgcgaggaaggaggucugaggaggucacugcgcc <<<<..........................>>>>. ((((...(........).((.....))...)))). Crystal structure of the Corn aptamer in unliganded state; RNA (36-MER) 6e81 A 36 2.721 URS0000BC4664_32630 31178406 32630 ggcgcgaggaaggaggucugaggaggucacugcgcc <<<<<..........................>>>>> (((((...(........).(.......)...))))) Crystal structure of the Corn aptamer in complex with ThT; RNA (36-MER) 6e82 A 36 3.101 URS0000EEAD12_32630 31178406 32630 ggcgcgaggaagguggucugaggaggucacugcgcc <<<<<..........................>>>>> (((((...(........).............))))) Crystal structure of the Corn aptamer mutant A14U in complex with ThT; RNA (36-MER) 6e84 A 36 2.901 URS0000BC4664_32630 31178406 32630 ggcgcgaggaaggaggucugaggaggucacugcgcc <<<<<..........................>>>>> (((((...(........).((.....))...))))) Crystal structure of the Corn aptamer in complex with TO; RNA (36-MER) 6e9f B 52 3.3 URS0000D7793D_1869227 30241607 1869227 cacccgugcaaaaaugcaggggucuaaaacgaccugaauauuucagaucaaa ..<<<.............>>>............................... ..(((.............)))............................... EsCas13d-crRNA-target RNA ternary complex; crRNA (52-MER) 6e9f C 27 3.3 URS0000D7790B_1869227 30241607 1869227 acguuuugaucugaaauauucaggucu ........................... ........................... EsCas13d-crRNA-target RNA ternary complex; RNA (27-MER) 6elz 1 2457 3.3 RF02540,RF02543 URS000061F377_559292 29245012 0003735 0005840 559292 guuugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugaauguaagaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggagggucggacgaucaacuuagggaaucugaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggacccuguugagcuugacucuaguuugacauuauugucagguggggaguaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ..........................<<<<<<.....<......>......>>>>>.>...<.....<<....>>..<<<<<......<<.....>>.....>>>>>..<<<..<........<<.<<<<<<...>>>>>>.>>........>....<<<<<<<.<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....<<<<<<..>>>>>>..>>>....>.............................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<<.....<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>.>>>>>..<<<<.<....>.>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<.<<<<<.......>>>.>>..>>....>>>>>>.>>>>>>..<<.<..<<<<<<<...<<<<<<<<<....<<<....<<<<<<<....>>>>>>>.....>>>.<.<<.<<........>>>>.>........>>>>>>>>>.<<<....>.>>...>>>>>>>.....>.>>..<<<<<<..................<<<<<<<<<....<<<.<<<<<<<..>>>>>.>>>>>..>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<<<<<<<<<<<<...((..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>.>.>>>>>>>.>>>>.........>>>>>>..........>.>>.>>>>>>>>>>>>..>>....>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<<<<<<..>>>>>...>..<<<<<<<<....>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<..<<<<<.<<<<<<<.<<<<<.<<<<<<<<....>>>>>>>>..>>>>>.>>>>>..>>>>>>>..............<<<<<...<<.......>>...>>>>>..<<<..<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>......>>>.......<<<<<<<....>>>.>>>>.........>>.>>>>>....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<...<<<<<<<<<<<))..>>>>>..>>>>>>..>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<.....<<<<........>>>>....>>>...>>>....>>>>.>>>>>..>>>>>.. ..........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........(((((((.((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))))....)))))))))))...)....(.(((((........))))).).....((((((..))))))..)))..................................((....))............(..((((....))))............).....................(((((.(((((......(((((((((((((((((((((((.......(((.(((......(((((......))))).......))).))).....))))).))))))))))........(((....)))....)))))))).....))))).)))))..((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).(((...((.......))....).))....)))))).))))))..((.(...((((((.....((((((((...((((...(((((((....)))))))...).))).(.((.((........)))).).......)))))))).....(....)......))))))......).))).((((((........(.....)...(((((.((.....(((.(((((((..))))).)))))...)).))).))..((((.((.((.....)).)).))))....(((......)))...(((((((...((([[[...(.(((((.......(...........((.((((((((((.....{.(((((.(.(...(...........)...).).....(...((......)).).)))))...))))))))))))...........]]].).....)))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....(((((.((...((((((...((.....)).))))))....[[(((.((...((....(((....)))........((((((........))))))....))....))...(((((........)))))]]((((.((((.(.....((((....)))...(...((((((...((((.(((((((((((((((((....[....)))))(...((((.....(((((.....(((.....))).....)))))......))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...)).......)..)))))))).)))..))....))))).((((.....))))..))))..((((.....(((((((.((..(....(.((.(((..))).)..)...(((((((.(..)..))))))).)..))).)))))))..))))))....)).[..(((((......].)))))....(((.(...(.((((((.(((((((.(((((.((((((((....))))))))..))))).)))))..))))))).).............((((...((.......))...))))..((((..(((((..(.(((((((......))))))..).).(.(.........).).....)))))......))).).....(((.(((....)))..))).........)..).)))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....(((((((.((.]..)).))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(((.((..)..).)))..)))))...)))....)))).)))))).))))).. State E (TAP-Flag-Ytm1 E80A) - Visualizing the assembly pathway of nucleolar pre-60S ribosomes; 25S ribosomal RNA 6elz 2 158 3.3 RF00002 URS00001BF64E_559292 29245012 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... State E (TAP-Flag-Ytm1 E80A) - Visualizing the assembly pathway of nucleolar pre-60S ribosomes; 5.8S ribosomal RNA 6elz 6 65 3.3 URS000013305B_559292 29245012 559292 ccuucucaaacauucuguuugguagugagugauacucuuuggaguuaacuugaaauugccuuaaa ......<<<<<<...>>>>>>.....<<<<...<<<<....>>>>..>>>>.............. .......((((.....)))).....(((((...(((.(...))))..))))..)........... State E (TAP-Flag-Ytm1 E80A) - Visualizing the assembly pathway of nucleolar pre-60S ribosomes; Internal transcribed spacer 2 6em1 1 1785 3.6 RF02540,RF02543 URS000061F377_559292 29245012 0003735 0005840 559292 guuugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaugguguuuugugcccucugcuccuuguggguaggggaaucucgcauuucacugggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaggauggauuugaguaagagcauagcuguugggacccgaaagauggugaaaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugaauguaagaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaagcgaaaccacagccaagggaacgggcuuggcagaaucagcgggggcuuguggcagucaagcguucauagcgacauugcucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcucccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugaugcuccacacagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ...........................<<<<<...................>>>>>...........<<....>>..<<<<<......<<.....>>.....>>>>>..<<<...........<<.<<<<<<...>>>>>>.>>.............<<<<<<<.<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....<<<<<<..>>>>>>..>>>..................................<<....>>...............<<<......>>>..................................<<<<<.<<<<<<.....<<<<...<<<..<<<<<<<<<.....>>>>>>>>>......>>>...>>>>..<<<<<<<<<<<<<<<<<<<<<<<.....<<<<<<<<<....<.<<<<<......>>>>>>......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>....>>>>>>>>....>>>>>>.>>>>>..<<<<.<....>.>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<.......>>>.>>>.>>....>>>>>>.>>>>>>..<<.<...<<<<<<....>>>>>>......>.>>..<<<<<<......<........>..<<<<<<<<<....<<<.<<<<<<<..>>>>>.>>>>>..>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<......<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>....>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<..>>....>>....<<<<<........>>>>>....<<<<<..<<.......<<<<<....<<.......>>....>>>>>..<<..<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>......>>...>>.>>>>>....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<....<<<<<<<<........>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.<<<<<<......<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>............>>>>>>.<<<<<<.....................<<<<<<<<<.<<<....<<<<....<<<<........>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>>. ..........................(((((......(......).......)))).).........((....))...((((......((.....)).....))))...((((.........(((.((((((...)))))).))....)........(((((((.((((.(((((((((((((((....{((((......)))).[[(...).(((....}]])))....))))))))..))))))).....)))))))))))...)....(.(((((........))))).).....((((((..))))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....((((...((((.((.((((((.....)))))).)).....))))...))))..(((((((((((((((((((((((.......(((((((......((((........)))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).)))))..((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...(......).......(((((..(((((....)))))...))))).(((((.((.......))..))).))....)))))).))))))..((.(...((((((....))))))......).))).((((((......(.(.....))..(((((.((.....(((.(((((((..))))).)))))...)).))).))..((((.((.((.....)).)).))))....(((......)))...(((((((...((([[[...(.(((((.......(...........((.((((((((((.....{.(.(((.(.(...((.........))...).).....(...((......)).).))).)...))))))))))))...........]]].).....)))))))))...)))))))(((((((((.........)))))))))....))))))((((((((((.((......((((.((((....))))))))...)))))))))).)).....))))))((.....((..))....)).[..(((((......].)))))....(((.(...(.......((((.....((.......)).....))))..((..(((((..(.(((((((......))))))..).).(.(.........).).....)))))......))...)..).))).....(((((((..((((.(.(((((......(....).....))))).)(((((...(((.....((((((((((....)))))..)))))....)))..))))).((((...((((.....}.......))))...)))).))))....)))))))..((((((......((.(........((((((.....)))))).....))).......((((((...((.((.(..(((......)))..).)).)).))))))............)))))).((((((.(..(.......)..)...(.(((((((((.((.....((((.(..(...((..)..)...)..)))))....))....)))).)))))).)))))). State C (Nsa1-TAP Flag-Ytm1) - Visualizing the assembly pathway of nucleolar pre-60S ribosomes; 25S ribosomal RNA 6em1 2 158 3.6 RF00002 URS00001BF64E_559292 29245012 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((.(((....))).)))))..................... State C (Nsa1-TAP Flag-Ytm1) - Visualizing the assembly pathway of nucleolar pre-60S ribosomes; 5.8S ribosomal RNA 6em1 6 65 3.6 URS000013305B_559292 29245012 559292 ccuucucaaacauucuguuugguagugagugauacucuuuggaguuaacuugaaauugccuuaaa ......<<<<<<...>>>>>>.....<<<<...<<<<....>>>>..>>>>.............. .......((((.....)))).....(((((...(((.(...))))..))))..)........... State C (Nsa1-TAP Flag-Ytm1) - Visualizing the assembly pathway of nucleolar pre-60S ribosomes; 5.8S ribosomal RNA 6em3 1 1250 3.2 RF02540,RF02543 URS000061F377_559292 29245012 0003735 0005840 559292 guuugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaugguguuuugugcccucugcuccuuguggguaggggaaucucgcauuucacugggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaggauggauuugaguaagagcauagcuguugggacccgaaagauggugaaaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugaauguaagaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaagcgaaaccacagccaagggaacgggcuuggcagagcuccacacagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcugcuggcgaauugcaaugcguggggauaa ..........................<<<<<<...................>>>>>.>...<.....<<....>>..<<<<<......<<.....>>.....>>>>>..<<<...........<<.<<<<<<...>>>>>>.>>.............<<<<<<<.<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....<<<<<<..>>>>>>..>>>....>.............................<<....>>...............<<<......>>>..................................<<<<<.<<<<<<.....<<<<...<<<..<<<<<<<<<.....>>>>>>>>>......>>>...>>>>..<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<....<.<<<<<......>>>>>>......>>>>>>>>..>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<.......>>>.>>>.>>....>>>>>>.>>>>>>..<<.<...<<<<<<....>>>>>>......>.>>..<<<<<<......<<......>>..<<<<<<<<<....<<<.<<<<<<<..>>>>>.>>>>>..>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<......<..))).>....>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<..>>....>>....<<<<<........>>>>>.....<<<<<<......<<..........<<<<<<.....>>>>>>......>>.......<<<<<<.>>>>>>............>>>>>>.... ..........................((((((...................))))).)...(.....((....))..(((((......((.....)).....)))))..(((...........((.((((((...)))))).)).............(((((((.((((.((((((.((((.(((.....((((......))))..[......(((.....].)))....))).))))...)))))).....)))))))))))........(((((((........))))))).....((((((..))))))..)))....).............................((....))...............((((....))))..................................(((((.((((((.....((((...(((..(((((.(((.....))).)))))......)))...))))..(((((((.((((((..(.(((((.....(((((((((....(.(((((......))))))......))))))).).).)))))..)..))))))........(((....))).....)))))))....)))))).)))))..((((........))))((((((....((((((.((((((..(((..(((((.....)))))..)))...(......).......(((((..(((((....)))))...))))).((((((((.......))).))).))....)))))).))))))..((.(..(((((((....))))))).....).))..((((((......(........)..(((((((((....(((.(((((((..))))).)))))..))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((..(((([[[.....((((((......(..]]].)....)))))).))))..)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((..))....))....(((((........))))).....((((((......((..........((((((.....))))))......)).......((.(((.))).))............)))))).... State A architectural model (Nsa1-TAP Flag-Ytm1) - Visualizing the assembly pathway of nucleolar pre-60S ribosomes; 25S ribosomal RNA 6em3 2 157 3.2 RF00002 URS00001BF64E_559292 29245012 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<......>>>>>>>>.................... ..........................................(((((.[[.....))).....(.((((.....]]............).)))..)...)).....((.....))(((((.((......)).))))).................... State A architectural model (Nsa1-TAP Flag-Ytm1) - Visualizing the assembly pathway of nucleolar pre-60S ribosomes; 5.8S ribosomal RNA 6em4 1 1556 4.1 RF02540,RF02543 URS000061F377_4932 29245012 0003735 0005840 4932 guuugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaugguguuuugugcccucugcuccuuguggguaggggaaucucgcauuucacugggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaggauggauuugaguaagagcauagcuguugggacccgaaagauggugaaaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugaauguaagaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaagcgaaaccacagccaagggaacgggcuuggcagaaucagcuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugaugcuccacacagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ..........................<<<<<<...................>>>>>.>...<.....<<....>>..<<<<<......<<.....>>.....>>>>>..<<<...........<<.<<<<<<...>>>>>>.>>.............<<<<<<<.<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....<<<<<<..>>>>>>..>>>....>.............................<<....>>...............<<<......>>>..................................<<<<<.<<<<<<.....<<<<...<<<..<<<<<<<<<.....>>>>>>>>>......>>>...>>>>..<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<....<.<<<<<......>>>>>>......>>>>>>>>..>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<.......>>>.>>>.>>....>>>>>>.>>>>>>..<<.<...<<<<<<....>>>>>>......>.>>..<<<<<<......<<......>>..<<<<<<<<<....<<<.<<<<<<<..>>>>>.>>>>>..>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<..>>....>>....<<<<<........>>>>>......<<<...>>>......<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<.<...<<<<<<<<<........>>>..>>>>>>..>.>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.<<<<<<......<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>............>>>>>>.<<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<........>>>>...>>>>...>>>....>>>.>>>>>>..>>>>>>. ..........................((((((...................))))).)...(.....((....))..(((((......((.....)).....)))))..(((...........((.((((((...)))))).)).............(((((((.((((.((((((.((((.(((.....((((......))))..[......(((.....].)))....))).))))...)))))).....)))))))))))........(((((((........))))))).....((((((..))))))..)))....).............................((....))...............((((....))))..................................(((((.((((((.....((((...(((..(((((.(((.....))).)))))......)))...))))..(((((((.((((((..(.(((((.....(((((((((....(.(((((......))))))......))))))).).).)))))..)..))))))........(((....))).....)))))))....)))))).)))))..((((........))))((((((....((((((.((((((..(((..(((((.....)))))..)))...(......).......(((((..(((((....)))))...))))).((((((((.......))).))).))....)))))).))))))..((.(..(((((((....))))))).....).))..((((((......(........)..(((((((((....(((.(((((((..))))).)))))..))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((..(((([[[.....(((((((....((..]]].)).).)))))).))))..)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((..))....))....(((((........)))))......(((...))).......(((((((..((((.(.((((((.....(....)....)))))).)(((((...(.(.....((((((((........)))..)))))....).)..))))).((((...(((((...........)))))...)))).))))....)))))))..((((((......((..........((((((.....))))))......)).......((.(((...(((((.(..(((......)))..).))))).))).))............))))))..(((((.(.............).....(((((((((.((.....((((....(((.(......).)))...))))....))....)))).)))))..))))).. State B architectural model (Nsa1-TAP Flag-Ytm1) - Visualizing the assembly pathway of nucleolar pre-60S ribosomes; 25S ribosomal RNA 6em4 2 158 4.1 RF00002 URS00001BF64E_4932 29245012 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<......>>>>>>>>..................... ..........................................(((((.[[.....))).....(.((((.....]]............).)))..)...)).....((.....))(((((.((......)).)))))..................... State B architectural model (Nsa1-TAP Flag-Ytm1) - Visualizing the assembly pathway of nucleolar pre-60S ribosomes; 5.8S ribosomal RNA 6em4 6 65 4.1 URS000013305B_4932 29245012 4932 ccuucucaaacauucuguuugguagugagugauacucuuuggaguuaacuugaaauugccuuaaa ......<<<<<<...>>>>>>.....<<<<.<.<<<<<..>>>>>>.>>>>.............. ......((((((...)))))).....((((.(.((((....))))).)))).............. State B architectural model (Nsa1-TAP Flag-Ytm1) - Visualizing the assembly pathway of nucleolar pre-60S ribosomes; internal transcribed spacer 1 6em5 2 158 4.3 RF00002 URS00001BF64E_559292 29245012 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<<...>>><<<<<<<<<....>>>>>>>>>..................... ..........................................(((((.[[.....))).....(.(((......]]..............)))..)...)).....((.....))(((((((((....)))))))))..................... State D architectural model (Nsa1-TAP Flag-Ytm1) - Visualizing the assembly pathway of nucleolar pre-60S ribosomes; 5.8S ribosomal RNA 6em5 1 2438 4.3 RF02540,RF02543 URS000061F377_4932 29245012 0003735 0005840 4932 guuugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugaauguaagaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggagggucggacgaucaacuuagggaaucugaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggacccuguugagcuugacucuaguuugacauuauugucagguggggaguaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugaugcuccacacagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ..........................<<<<<<.....<......>......>>>>>.>...<.....<<....>>..<<<<<......<<.....>>.....>>>>>..<<<..<........<<.<<<<<<...>>>>>>.>>........>....<<<<<<<.<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....<<<<<<..>>>>>>..>>>....>.............................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<<.....<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>.>>>>>..<<<<.<....>.>>>><<<<<<...<<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<.<<<<<.......>>>.>>..>>....>>>>>>.>>>>>>>.<<.<..<<<<<<<...<<<<<<<<<....<<<....<<<<<<<....>>>>>>>.....>>>.<.<<.<<........>>>>.>........>>>>>>>>>.<<<....>.>>...>>>>>>>.....>.>>..<<<<<<....<............><<<<<<<<<....<<<.<<<<<<<..>>>>>.>>>>>..>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<<<<<<<<<<<<...((..>>>>>><<..<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>>...><<<<<<<......>>>>>>>>>>>.>.>>>>>>>.>>>>.........>>>>>>..........>.>>.>>>>>>>>>>>>..>>....>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<<<<<<..>>>>>...>..<<<<<<<<....>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<..<<<<<.<<<<<<<.<<<<..<<<<<<<<....>>>>>>>>...>>>>.>>>>>..>>>>>>>..............<<<<<...<<.......>>...>>>>>..<<<..<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>......>>>.......<<<<<<<....>>>.>>>>.........>>.>>>>>....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<...<<<<<<<<<<<))..>>>>>..>>>>>>..>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.<<<<<<......<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>............>>>>>>.<<<<<<.....................<<<<<<<<<.<<<....<<<.....<<<<........>>>>....>>>...>>>....>>>>.>>>>>..>>>>>>. ..........................((((((.....(......)......))))).)...(.....((....))..(((((......((.....)).....)))))..(((..(........((.((((((...)))))).))........)....(((((((.((((.((.((((((((((((.....((((......))))..[......(((.....].)))....))))))))..)))).)).....)))))))))))........(((((((........)))))))......(((((..)))))...)))....).............................((....))...............((((....))))..................................(((((.((((((.....(((((((.(((((((((.(((((.....(((((.(((.(....((((.(....).))))..)....))).))).).).)))))..)))))))))........(((....))).....)))))))....)))))).)))))..((((.(....).))))((((((....((((((.((((((..(((...((((.....))))...)))...((....)).......(.(((..(((((....)))))...))).).((..((((.......))).)...))....)))))).))))))..((.(..(((((((...(((((((((....(((....(((((((....))))))).....))).(.((.((........)))).)........)))))))))..((....).)....))))))).....).))..((((((....(............)(((.(((((....(((.(((((......))).)))))..))))).).))..((((.(((((.....))))).))))....(((......)))...(((((((..(((([[[.....((((((.....((..........(((.((((((((((.......(((((.(((...((.........))...))).........((......))...)))))...)))))))))))))..........]]].))...)))))).))))..)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....(((((.((...((((((...((.....)).))))))....[[(((.((...((....(((....)))........((((((........))))))....))....))...(((((........)))))]]((((.((((.(......(((....)))...(...((((((...((((.(((((((((.((((.((....[[...)).))(...(((((....(((((.....(((.....))).....))))).....)))))....).((((((......)))))).)).).).))))))).)))).........))))))...)........)..)))))))).)))..))....))))).(((.......)))..))))..((((.....(((((((.((.......(..(((((..)))))......(((((((.......))))))).)...)).)))))))..))))))....))....(((((........)))))....(((((..((..(((((.(((((((.((((..(.((((((....)))))).)...)))).)))))..))))))).............((((((...((.......))...))))))..((.((((((..(.(((((((......)))))))...).(((.........))).....)))))..)...)).........((((((....))).)))..........)).))))).....(.(((((..((((.(.((((((.....(....)....)))))).)(((((...((((....(((((((.((]]..)).))..)))))...))))..))))).((((...((.((...........)).))...)))).))))....))))).)..((((((......((..........((((((.....))))))......)).......((((((...(((((.(..(((......)))..).))))).))))))............))))))..(((((.(.............).....(((((((((.(((....((((....(((..........)))...))))...)))....)))).)))))..))))).. State D architectural model (Nsa1-TAP Flag-Ytm1) - Visualizing the assembly pathway of nucleolar pre-60S ribosomes; 25S ribosomal RNA 6enf a 1539 3.2 RF00177,RF01959,RF01960 URS000080DDC0_562 29100052 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<......<<.<<<..<<<..<<.<...<<<<<<<..........>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>..........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<........<<<.........>.>>.....>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<.<.<<<......>>>.....>>>>>>>>>...........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<..<.<<<<<<<........>>>>>>>>...>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((......(.(((..(((..((.((..(((......(....).......)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...))))...).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((((.......)))))))).....)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((.........((.(........)).)......))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....))))))).............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Cryo-EM structure of a polyproline-stalled ribosome in the absence of EF-P; 16S ribosomal RNA 6enf A 2807 3.2 RF02540,RF02541 URS0000B21DDD_562 29100052 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugucgaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccgggagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccguaaaccuuuacuauagcuugacacugaaugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<.......<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>....>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<..>>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<........................>........<<......>>...>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<..<<....>>..>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<....<<..>>.....>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.......<<<<<<.<<....>>..>>>>>>.......>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<...<<<<..<<<<<.<<<.<<<<<.<<.......>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>....>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..((((((((.((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[......(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......))..)))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((((..)))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((..........).))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.((((..(........................)......................))))...)))..))))).))...........]]].)...))))))))))...)))))))((((..............))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((.(((.((.....)))).)))))..))))..[))))...))(..((((......))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(.((....])).)...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((..(((((..(((((.(((.(((((.(((.....)))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..).))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Cryo-EM structure of a polyproline-stalled ribosome in the absence of EF-P; 23S ribosomal RNA 6enf B 120 3.2 RF00001 URS00008116C5_562 29100052 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Cryo-EM structure of a polyproline-stalled ribosome in the absence of EF-P; 5S ribosomal RNA 6enf x 77 3.2 RF00005 URS00001DEEBE_562 29100052 0030533 0006412 562 cggugauuggcgcagccugguagcgcacuucguucgggacgaaggggucggagguucgaauccucuaucaccgacca <<<<<<<..<<<<.........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.........)))).(((((.......))))).....(((((.......)))))))))))).... Cryo-EM structure of a polyproline-stalled ribosome in the absence of EF-P; proline tRNA 6enj A 2871 3.7 RF02540,RF02541 URS0000CBFF60_562 29100052 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugucgaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccgggagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccguaaaccuuuacuauagcuugacacugaacauugagcuuugauguguaggauaggugggaggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<.......<<<<<<<<<<<<.<<<....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>>>....>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<<..>>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<...<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>.....>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<......>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<......<.............>.............<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<..<<....>>..>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>.>........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<..<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.......<<<<<..<<....>>...>>>>>.......>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>.....>>..>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<...<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<..<<<............<<<<......................>>>>...>>>..>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>....>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<.<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>...>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.<...<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>>....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).((((((((...........)))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......((((.((((((((.(((...(((((......)))))[[......(((.....]])))...)))...)))))))).))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((((..)))))))..))))...(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.((.......))...)..))))))......).))..((((((....(((((....))))).((((((((...(((((((((.....(((...(((.((((...(..(........)...)...)))).)))..)).).....))))))).))...))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.((((...................................(((......)))...))))...)))..))))).))...........]]].)...))))))))))...)))))))((((..............))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](.((((((((.((...((((....((((..(((..(((((((((((....{{{...))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..((((......))))...))))))...)))...))))(..).....))))...)).....)))))))).).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..((.((((..(((........((.((..((....))...)).))........)))))))...)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).[..(((((......].)))))..((((((((.(((.((......((((..(((((..(((((.(((.(((((.(((((((((....(((...........(((.(.....................))))..)))....)))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))(.((...(((((((...(((((.........))))).....((.[.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..).))))......((((..(.((((((...((.......))...))))))...).)).).)......(..(.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...)...).....(..((((....))).)..)....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))....((....(.((.....}.......)).)....))..))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Polyproline-stalled ribosome in the presence of A+P site tRNA and elongation-factor P (EF-P); 23S Ribosomal RNA 6enj B 120 3.7 RF00001 URS00008116C5_562 29100052 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((.(((((....(((((((...(.....)...))))..)))...)))))..)).((.......((((((((...)))))))).......))...)))))))))). Polyproline-stalled ribosome in the presence of A+P site tRNA and elongation-factor P (EF-P); 5S Ribosomal RNA 6enj a 1539 3.7 RF00177,RF01959,RF01960 URS000080DDC0_562 29100052 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<......<<.<<<..<<<..<<.....<<<<<<<.........>.>>>.>>>....>>>>>......<<.......<<<<<<<..<<....<<<<<<.<.<<...<.<<<.<......>.>>>.>....>>.>.....<<<....>>>....<<<<<<..........>>>>>>.>>>>>>...>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<.<<.........>>>>>>.<<<<....>>>>...>>>>>..........<<<....<<<......>>>..>>>..>>.>>>>>>.....<.......<<<....>>>......>.........<<<<........<<.<<<.<........>>>>.>>..........>>>>........<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<.......<<<.<......>>>>.....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>.>..........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<..<.<<<<<<<........>>>>>>>>...>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<...<<....>>..>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(..(((..(.....((.(((..(((..(..(....(((.....(....).....).))..)...))))......(((......(((((((..((.....(((((.(.((.....(((.((....)).)))......)).).....(((....))).....(..(............)..)..)))))....)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))..).....(.((.....(((......)))...)))....)))..)..(.........((((....))))........)...(...(((...(..(.((.((.............)).)).)...)....)))......)...(((([[[...(((((.....((.]]])).......)))))))))...)))))))))..........((([[...(.((((...(((.(((((((.(((((((((........(...(......)...).....)))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((.(.....).))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))....(....)...))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Polyproline-stalled ribosome in the presence of A+P site tRNA and elongation-factor P (EF-P); 16S ribosomal RNA 6enj x 77 3.7 RF00005 URS00001DEEBE_562 29100052 0030533 0006412 562 cggugauuggcgcagccugguagcgcacuucguucgggacgaaggggucggagguucgaauccucuaucaccgacca <<<<<<<..<<<<.........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... .((((.(..((((.........)))).(((((.......)))))......((((.......)))).).))))..... Polyproline-stalled ribosome in the presence of A+P site tRNA and elongation-factor P (EF-P); Proline tRNA 6enj 9 77 3.7 RF00005 URS00001DEEBE_562 29100052 0030533 0006412 562 cggugauuggcgcagccugguagcgcacuucguucgggacgaaggggucggagguucgaauccucuaucaccgacca <<<<<<<..<<<<.........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))).... Polyproline-stalled ribosome in the presence of A+P site tRNA and elongation-factor P (EF-P); Proline tRNA 6enu a 1539 3.1 RF00177,RF01959,RF01960 URS000080DDC0_562 29100052 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<......<<.<<<..<<<..<<.<...<<<<<<<..........>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<.<.<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>..........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<.......<<<.........>>.>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((......(.(((..(((..((.((..(((...................)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..(......))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...))))...).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((.(.......).)))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((.........(((.........)).)......))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....))))))).............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Polyproline-stalled ribosome in the presence of elongation-factor P (EF-P); 16S ribosomal RNA 6enu A 2871 3.1 RF02540,RF02541 URS0000CBFF60_562 29100052 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugucgaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccgggagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccguaaaccuuuacuauagcuugacacugaacauugagcuuugauguguaggauaggugggaggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<.......<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>....>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<<..>>>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<....>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<......<.............>.............<<........>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<..<<....>>..>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<<.<<....>>..>>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<...<<<<..<<<<<.<<<.<<<<<.<<<<<<<<....<.<<...........<<<<<....................>>>>>..>>.>....>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>....>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((.......((((((((((((.(((...(((((......)))))[[......(((.....]])))...)))...))))))))))))....))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((((..)))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(.(...(..)...)..)...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{..(((..(........................)....(...(.........))..)))....)))..))))).))...........]]].)...))))))))))...)))))))(((((............)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((..(((((..(((((.(((.(((((.(((((((((....(((.(.........(((.(..(....).............))))).)))....)))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..).))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Polyproline-stalled ribosome in the presence of elongation-factor P (EF-P); 23S Ribosomal RNA 6enu B 120 3.1 RF00001 URS00008116C5_562 29100052 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Polyproline-stalled ribosome in the presence of elongation-factor P (EF-P); 5S Ribosomal RNA 6enu x 77 3.1 RF00005 URS00001DEEBE_562 29100052 0030533 0006412 562 cggugauuggcgcagccugguagcgcacuucguucgggacgaaggggucggagguucgaauccucuaucaccgacca <<<<<<<..<<<<.........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))).... Polyproline-stalled ribosome in the presence of elongation-factor P (EF-P); Proline tRNA 6eri AA 2696 3.0 RF02540,RF02541 URS000028B73E_3562 29610536 0003735 0005840 3562 ucaaacgaggaaaggcuuacgguggauaccuaggcacccagagacgaggaagggcguauuaaucgacgaaaugcuucggggaguugaaaauaagcagagauccggagauucccgaauaggucaaccuuucgaacuucugcugaauccaugggcaggcaagagacaaccuggcgaacugaaacaucuuaguagccagaggaaaagaaagcaaaagcgauucccguaguagcggcgagcgaaaugggagcagccuaaaccgugaaaacgggguugugggagagcaauacaagcgucgugcugcuaggcgaaucaguggagugcggaacccuagauggugaaaguccaguagccgaaagcaucacuagcuuaugcucugacccgaguagcauggggcacguggaaucccgugugaaucagcaaggaccaccuugcaaggcuaaauacuccugggugaccgauagcgaaguaguaccgugagggaagggugaaaagaacccccaucggggagugaaauagaacaugaaaccguaagcucucaagcagugggagggggaccagacccugaccgcgugccuguugaagaaugagccggcgacucauaggcaguggcuugguuaagggaacccaccggagccguagcgaaagcgagucuucauagggcaauugucacugcuuauggacccgaaccugggugaucuauccaugaccaggaugaagcuugggugaaacuaaguggagguccgaaccgacugauguugaagaaucagcggaugaguugugguuaggggugaaaugccacucgaacccagagcuagcugguucuccccgaaaugcguugaggcgcagcaguugacuggacaucuagggguaaagcacuguuucggugcgggccgcgguaccaaaucgaggcaaacucugaauacuagauaugaccuccaaauaacaggggucaaggucggccagugagacgaugggggauaagcuucaucgucgagagggaaacagcccggaucaccagcuaaggccccuaaaugaccgcucagugauaaaggagguaggggugcagagacagccaggagguuugccuagaagcagccacccuugaaagagugcguaauagcucacugaucgagcgcucuugcgccgaagaugaacggggcuaagcggucugccgaagcugugggauguaaaaaaacaucgguaggggagcguuccguguuagggagaaacgcgugcgugagccgcguuggacgaagcggaagcgagaaugucggcuugaguaacgcaaacauuggugagaauccaaugccccgaaaaccuaaggguuccuccgcaagguucguccacggagggugagucagggccuaagaucaggccgaaaggcguagucgauggacaacaggugaauauuccuguacuaccccuuguuggucccgagggacggaggaggcuagguuagccgaaagaugguuaucgguucaaggacgcaaggugacccggguaagaagggguagagaaaaugccucgagccaauguucgaguaccaggcgcuacggcgcugaaguaaccgaugccauacucccaggaaaagcucgaacgaccuucaacaaaaggguaccuguacccgaaaccgacacagguagguagguagagaauaccuaggggcgcgagacaacucucucuaaggaacucggcaaaauagccccguaacuucgggagaaggggugcccccucacaaagggggucgaagugaccaggcccgggcgacuguuuaccaaaaacacaggucuccgcaaagucguaagaccauguaugggggcugacgccugcccagugccggaaggucaaggaaguuggugaccugacaggggagccggcgaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgacccgcacgaaaggcguaacgaucugggcacugucucggagagaggcucggugaaauagacaugucugugaagaugcggacuaccugcaccuggacagaaagacccuaugaagcuuuacuguucccugggauuggcuuauucuaaccuugugucaggaccuacgggccaagggacauucucagguagacaguuucuauggggcguaggccucccaaaagguaacggaggcgugcaaagguuuccucgggccggacggagauuggcccucgagugcaaaggcagaagggagcuugacugcaagacccacccgucgagcagggacgaaagucggccuuagugauccgacggugccgaguggaagggccgucgcucaacggauaaaaguuacucuagggauaacaggcugaucuuccccaagaguucacaucgacgggaagguuuggcaccucgaugucggcucuucgccaccuggggcuguaguauguuccaaggguugggcuguucgcccauuaaagcgguacgugagcuggguucagaacgucgugagacaguucgguccauauccggugugggcguuagagcauugagaggaccuuucccuaguacgagaggaccgggaaggacgcaccucugguguaccaguuaucgugcccacgguaaacgcuggguagccaagugcggagcggauaacugcugaaagcaucuaaguaguaagcccaccccaagaugagugcucuccua .............<<<<<<<<<<.....<<..<<<<<<<<<<<.<......<<<<<<.....((.>>>.....<<<<<<<..<<.))......>>.....>>>>>>>...>>>....<<<....>>>......<<<<<<<<.........>>>>>..>>>.>....<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<....<<<<....>>>>......<<<<<<<<......<<....<<<.<<<<.<<<...<<.<<.....>>.>>((......<<<.....))>>>...>>>...>>>>.>>>....>>..>>>>>..>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..>>>......>>.>>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>........<<<<..<<<<.......>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<...<<<...<<.......>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>..<<.<...<<<<<<.....<.<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>.>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<.<<<<<<<....<<<<<<......<<...<<<<<<<<...<...........>...>>>>>>>>..>>.......>>>>>>..<<<<<...........>>>>>..>>>>>>>..>>..<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<<.......<.<<<.<<<...<<.........>>...>>>.........<<......>>...>>>.>...>>>>>>>>>>.>>..........))).....>>>>>>.>>>...>>>>>>><<<<<......>>>>>....>>>>>><<<<<<<<...........<<<<<.<<....>>>>>>.>.......>>>>>>.>>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<.<<<<.<<<<.<<<<....<<<<..<<<..<<<<<<<<<<.....(((..>>>>>....<<<<<...<<<.<<....>>.....<<<<<<.......>>>>>>..>>>..>>>>>.....<..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>>>....>>.>>.>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.......>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<..<<<<<<..<<<<.>>>>...>>>>>>..>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<..<......<<<<.<<<<<<..<<<<<..<<<<<<<..<<.<.>.>>...<<<<<.<<<..........>>>>>>>>.....>>>>>>>...>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<..<<<<<<<.......>>>>>>>....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..>>>>..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<.<<<<..<<<<<<<<........>>>>>..>>>.<<<<<.....>>>>>.....>>>>...>...>>>.>>....<<<<<<<....>>>.>>>>....>...>>>>>>>>>>>....<<<<<<<...<.<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>...>>>>>...>>>>.>>>>>..<.<<.<.<<<<<<...........>>>>>>..>>>>.>>.>.......>>>>>>>.... .............(((((((((......((..(((((((((((.(......((((((..[..[[[)))...].((((((...(((]]..]..)))......))))))...)))....(((....)))(..)..((.(((((.........)))))...)).)....((((((.....(...[..)......))))).).........((....))...((((......((.]...)).....))))...((([...((((....))))....(.(((.(((.......((....(((.((((.(((...((.((.....)).))[[(...).(((.....]])))...)))...)))).)))....))...)))...)))]....(((((((...[.......)))))))....).(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((....))))............)......)))))))))......(.((((..((((.......))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.......))...)))...((....))..((((.....))))....)))))))))))))..((.(...((((((.....(.((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))).).(.(((....[)))...).]))))))......).))..((((((....(((((....)))))((.(((((((....((((((.....(((...(((.(((((....(........)...))))).)))..)).).....))))))..(((((...........)))))..)))))))..))..((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((.((((.....{.(.(((.((....((.........))....)).....(...((......)).).))).)...)))).))))).))..........]]].)...))))))))))...)))))))(((((......)))))....))))))(.((((((....(......(((((.((....)))))).)...)...))))))..).....))))))(......((.....((((((.......))))))((((....(((...((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((.((((.((((.((((....((((..(((..((((((((((.....{{{..)))))((..((((....(((..............((((((.......))))))..)))...))))..).)(..(((((....)))))...))))))...)))...))))(..).....))))...))))....))))..))))))))).))).....((......))..))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.......))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((..((((((..((((.))))...))))))..))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....))....(((((.....]..)))))..((((((((.(((..(......((((.((((((..(((((..(((((((..((.(.).))...(((((.(((..........)))))))).....)))))))...)))))..(((......[)))((((((..........]))))))([((...(((((((.(((((((.........))))))..).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.(.((((..((((((((........)))))..))).(((((.....))))).....))))...)...))).))....(((((((....))).))))....)...)))))))))))[...(((((((...(.((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))...)))))...)))).)))))..(.((....((((.....}.......))))....))).)).)..]....))))))).... Structure of the chloroplast ribosome with chl-RRF and hibernation-promoting factor; 23S ribosomal RNA 6eri AB 106 3.0 RF02541 URS000000A081_3562 29610536 0003735 0005840 3562 agagaaggucacggcgagacgagccguuuaucauuacgauaggugucaaguggaagugcagugauguaugcagcugaggcauccuaacagacccacagacuugaac ......<<<<<<<<<.......>>>>>............<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>............. ......((((.((((.......)))).............((((((((.(((....(((((....)))))...)))..))))).)))...))))............. Structure of the chloroplast ribosome with chl-RRF and hibernation-promoting factor; 4.5S ribosomal RNA 6eri Ax 118 3.0 RF00001 URS0000D56C4F_3562 29610536 0003735 0005840 3562 uucugguguccuaggcguagaggaaccacaccaauccaucccgaacuuggugguuaaacucuacugcggugacgauacuguaggggagguccugcggaaaaauagcucgacgccagga <<<<<<<<<<....<<<<<<<<.....<<<<<<<............>>>>>.>>....>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>> ..((((((((....((((((((.....(((((((..(.....)...))))).))....)))))).))(((.......((((((((....)))))))).......))).)))))))).. Structure of the chloroplast ribosome with chl-RRF and hibernation-promoting factor; 5S ribosomal RNA 6eri BA 1481 3.0 RF00177,RF01959,RF01960 URS0000D56C50_3562 29610536 0003735 0005840 3562 ucucauggagaguucgauccuggcucaggaugaacgcuggcggcaugcuuaacacaugcaagucggacgggaagugguguuuccaguggcggacgggugaguaacgcguaagaaccugcccuugggaggggaacaacagcuggaaacggcugcuaauaccccguaggcugagaagcaaaaggaggaauccgcccgaggaggggcucgcgucugauuagcuaguuggugagguaauagcuuaccaaggcgaugaucaguagcugguccgagaggaugaucagccacacugggacugagacacggcccagacuccuacgggaggcagcaguggggaauuuuccgcaaugggcgaaagccugacggagcaaugccgcguggaggcagaaggcccacgggucgugaacuucuuuucccggagaagaagcaaugacgguauccggggaauaagcaucggcuaacucugugccagcagccgcgguaagacagaggaugcaagcguuauccggaaugauugggcguaaagcgucuguagguggcuuuuuaaguccgccgucaaaucccagggcucaacccuggacaggcgguggaaacuaccaagcuggaguacgguaggggcagagggaauuuccgguggagcggugaaaugcguagagaucggaaagaacaccaacggcgaaagcacucugcugggccgacacugacacugagagacgaaagcuaggggagcgaaugggauuagauaccccaguaguccuagccguaaacgauggauacuaggcgcugugcguaucgacccgugcaguguuguagcuaacgcguuaaguaucccgccuggggaguacguucgcaagaaugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaaagcgaagaaccuuaccagggcuugacaugccgcgaauccucuugaaagagaggggugccuucgggaacgcggacacagguggugcauggcugucgucagcucgugccguaagguguuggguuaagucccgcaacgagcgcaacccucguguuuaguugccaacguugaguuuggaacccugaacagacugccggugauaagccggaggaaggugaggaugacgucaagucaucaugccccuuaugcccugggcgacacacgugcuacaauggccgggacaaagggucgcgaucccgcgagggugagcuaaccccaaaaacccguccucaguucggauugcaggcugcaacucgccugcaugaagccggaaucgcuaguaaucgccggucagccauacggcggugaauucguucccgggccuuguacacaccgcccgucacacuaugggagcuggccaugcccgaagucguuaccuuaaccgcaaggagggggaugccgaaggcagggcuagugacuggagugaagucguaacaagguagccguacuggaaggugcggcuggau .........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<<<<.....>>>>>.>>>>>......<<.......<<<<.<<..<<<..<<<<<<<.<<<<.....<<<<<......>>>>>......>>>>....<<<....>>>....<<......>>.>>>>>>>.>>>.>>.>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<<..................>>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<..<.<<<<<<<<<<<.....<<<<<<.....>>>>>>...>>>>>>>>..>>>>..>>>>...<<<.<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>.>..........<<....>>.>>>>>>>..>>>>..>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<........>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<<<........>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<.<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>.>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<...<<<<.<<<..<<<<<<<.<<<<....<.<<<<.<<<<..<<....>>.>>>>>>>>.>...>>>>.>>>>>>>..>>>.>>>>....>>...>.....<<<<<<<<<....>>>>>>>>>.... .........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((.......)))).)))))......(((......((((.((..(((..(((((((.(.((.....((((((....))))))......)).)....(((....)))....((......)).))))))).))).)).))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....((((((...(.........)....))))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.((((..(.((.((((((((.....((((((.....))))))...))))))))...)))..))))...((..(.((...(((((.((...((.((.((...((........))......)).)).))...).......((....)).).)))))..)).)...))...)))...))))....(((.((...(.....(((.........))).....))).)))......{...((((((..(((.(((((((........))))))).)))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..(((.((((((......((........))..........(((((((..(...(((((((...((((((....))))))....((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((..((..((...((((........))))....))..))...(...((((.....))))......)..)))).....).).)))...)).)))))....)))))))..[)).)))).))).(...((.((((.....(((..((...(((....)))...))....))).....)))).))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((.((((....(.((((.((((..((....)).)))))))).)...)))).)))))))..))).))))..).))...)..)..(((((((((....)))))))))}... Structure of the chloroplast ribosome with chl-RRF and hibernation-promoting factor; 16S ribosomal RNA 6evj R 13 3.9 URS000080E01C_11320 29202182 11320 uauaccucugcuu ............. ............. Crystal structure of bat influenza A/H17N10 polymerase with viral RNA promoter and capped RNA primer; RNA (5'-R(*UP*AP*UP*AP*CP*CP*UP*CP*UP*GP*CP*UP*U)-3') 6evj S 13 3.9 URS000080E01C_11320 29202182 11320 uauaccucugcuu ............. ............. Crystal structure of bat influenza A/H17N10 polymerase with viral RNA promoter and capped RNA primer; RNA (5'-R(*UP*AP*UP*AP*CP*CP*UP*CP*UP*GP*CP*UP*U)-3') 6evj U 15 3.9 URS000080DFE6_11320 29202182 11320 aguaguaacaagagg .<<....>>...... .((....))...... Crystal structure of bat influenza A/H17N10 polymerase with viral RNA promoter and capped RNA primer; RNA (5'-R(P*AP*GP*UP*AP*GP*UP*AP*AP*CP*AP*AP*GP*AP*GP*G)-3') 6evj V 15 3.9 URS000080DFE6_11320 29202182 11320 aguaguaacaagagg .<<....>>...... .((....))...... Crystal structure of bat influenza A/H17N10 polymerase with viral RNA promoter and capped RNA primer; RNA (5'-R(P*AP*GP*UP*AP*GP*UP*AP*AP*CP*AP*AP*GP*AP*GP*G)-3') 6evk R 13 2.9 URS000080E01C_11320 29202182 11320 uauaccucugcuu ............. ............. Crystal structure of bat influenza A/H17N10 polymerase with viral RNA promoter and cap analogue m7GTP; RNA (5'-R(*UP*AP*UP*AP*CP*CP*UP*CP*UP*GP*CP*UP*U)-3') 6evk V 16 2.9 URS000080DFE6_11320 29202182 11320 aguaguaacaagaggg .<<....>>....... .((....))....... Crystal structure of bat influenza A/H17N10 polymerase with viral RNA promoter and cap analogue m7GTP; RNA (5'-R(P*AP*GP*UP*AP*GP*UP*AP*AP*CP*AP*AP*GP*AP*GP*GP*G)-3') 6exn 2 136 3.7 RF00004 URS000023C730_559292 29146871 0045131 0000348 0005686 559292 gaaucucuuugccuuuuggcuuagaucaaguguaguaucuguucuuuguaacauguuacaauaccauuuuuuggcaggacgggaagaggagacgucgcgacccucgcaggucgcuugauguuucuucuucccguuc ..............................................<<<<<<<>>>>>>>................<<<<<<<<<<<.<<<<<<<<<<<<.<<.....>>>>>>..>>>>>>>>.>>>>>>>>>>> ..............................................((((((()))))))................(((((((((((.((((((((((((.((.....))))))..)))))))).))))))))))) Post-catalytic P complex spliceosome with 3' splice site docked; U2 snRNA 6exn 5 171 3.7 RF00020 URS0000514318_559292 29146871 0000244,0000353 0005682,0046540 559292 aagcagcuuuacagaucaauggcggagggaggucaacaucaagaacugugggccuuuuauugccuauagaacuuauaacgaacaugguucuugccuuuuaccagaaccauccggguguugucuccauaaacagguaaagcuguccguuacugugggcuugccauuuuuugg ..<<<<<<.<<<<<.......<<<<..<<<<<.<<<<<<<.....<<<<<<<<........>>>>>>>>..............<<<<<<<<...........>>>>>>>>...>>>>>>>>>>>>....<<<<......>>>>>>>>..>>>>>>>>.>>>.......... ..(((((((.((((.......((((..(((((.(((((((.....((((.(((........))).)))).........((...((((((((...........)))))))).))))))))))))))....((((......))))))))..)))))))).))).......... Post-catalytic P complex spliceosome with 3' splice site docked; U5 snRNA 6exn 6 102 3.7 RF00026 URS00006184A9_559292 29146871 0030621 0000244,0000353 0005688,0046540 559292 guucgcgaaguaacccuucguggacauuuggucaauuugaaacaauacagagaugaucagcaguuccccugcauaaggaugaaccguuuuacaaagagauuu <<<<<<<<<<.....>>>>>>>>>>.....................................<<<..<<<.....>>>...>>>.................. ((((((((((.....)))))))))).....................................(((.((((.....)))..)))).................. Post-catalytic P complex spliceosome with 3' splice site docked; U6 snRNA 6exn E 32 3.7 29146871 559292 agugaucuagaaagagauccaccuacucaugu ................................ ................................ Post-catalytic P complex spliceosome with 3' splice site docked; Ligated exons: UBC4 mRNA 6exn I 39 3.7 URS0000B21DEE_559292 29146871 559292 guaugucuaaaguuaugcucuuauuuacuaacaaacuag ....................................... ....................................... Post-catalytic P complex spliceosome with 3' splice site docked; Intron lariat: UBC4 RNA 6f5o R 14 9.8 URS0000B21E03_1601067 29910112 1601067 uauaccucugcuuc .............. .............. A mechanism for the activation of the influenza virus transcriptase; 3' promoter vRNA 6f5o V 14 9.8 URS000080E200_1601067 29910112 1601067 aguaguaacaagag .<<....>>..... .((....))..... A mechanism for the activation of the influenza virus transcriptase; 5' promoter vRNA 6fec A 1776 6.3 RF01960,RF01959,RF00177 URS0000A7635E_9606 29401259 0003735 0005840 9606 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucgcuccucuccuacuuggauaacugugguaauucuagagcuaauacaugccgacggcgcugacucccuuugugugggaugcgugcauuuaucagaucaaaaccaacccggucagcggcggcggcuuuggugacucuagauaaccucgggccgaucgcagcccuccguggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggucgcagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugagggcccgccccucggcgcccccucgaugugucccgcggggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauucugugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagaugucggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggcccgccggggucggcccacggcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<...[[[[>>>>>[[[.((((((................[[[.[[[...<....<.....<<..........>>....>.>.......{{........[[[.{..........[[[[[..................<<.....<<..<.......>..>>......>>..........<<...<<..........>>...>>..[[..(((((.......<<<<<<<<<<.<........>>>>..............)))))......]]...<<<...<<......>>...>>>.]].]]].......}.]]].<<<....<<<.....<<<<<<.........>>>>>>.>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<.<<<<<.<<<....>>>.>.>>>>..>>>......<...................>.........<<<<<((......<<<<.........)).........>>>>.>>>>>..)))))).]]]............<<.......{{...[[[.[[....<.<..>.>..........<<<<<...............>>>>>.........<<<<<..........<<..............<<<.......>>>....>>.........>>..>>>.......[[....[.(((((.....>>>>>>>...))))).]...]]....]]....<<<<<<..<...<<<<..<<<.<<<<<<<<...<<<......>>>......>>>>>>>>.>>>.......<<....>>...>>>>..>..>>>.>>>...]]]...}}......<<<<<.....<...<<.............>>...>..>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<..>>>>...>>.....>>>......<<......<<<......>>>....>>...]]]]..<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.......<<<<<.......<<.<<<........>>>.>>.....>>>>>....<..<<<....<<<<<<.....<<<.<<<<......>>...<<<......>>>...>>.>>>....<<<.......<<<<..<<<<.......<..<<<....>>>>........>>>>..>>>>........<<<<<.....>>>>>........>>>.....>>.>>>...>...>>>.>......>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>..........<.<<<<<..........>>>>>>..........>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>.......<<.....<<<.<<....<<<<<<<<.<<...<<<<..<...<<<<<<<<<<<<<<...........>>>>>>>>>...>>>>>...>..>>>>...>>.>>>>>>>>...>>.>>>......>>.........<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((..((....((.....(..........)....)){))......(((.......(((.(.(..((....(((.(..............(...((.....((.(((.....))).))......))..........((...((.(......).))...))..((..(((((.....[[[[[[[[.(((...........)))....(......)..)))))......))..)((((.(((......))).)))).)..)))...))).).))).(((....(((....(((.(((.........))).))))))......)))...(((.((((....))))....)))))).(([(((........].))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)...)).)......(..((((..(((....)))...))))...).......((..(...........)..)).........((((([[......((((.....((..]])).......)))).)))))..)))))).)))..{......(..{{...(.(.((...(((..(....(.(..).)..........(((((..(..........).))))).........(((((..........((...(.......)...((.......)).....)).........))..))).......((.(..(..(.((......]]]]]]]].)).)..)..)))....)....(((.(((..(...((((..(((.((((((((...((........))......)))))))).))).......((....))...))))..)..)))..))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..(.((((((.(((........))))))))).)..)))...((..}}))...))...}.))))..).(((......((((....))))....)))...]]].](((((.((((((...((..(((((..(((.((((((......((........))..........(((((.(....(((.(.....(..((.(((........)))).)....).).)))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((...(...((((..((((.....(((..(((....)))).)).....))))..))))..)..(..(((((.....)))))....)...)))....))).))).....).))))).....))))))...)).)))).))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....((((((((.......))))))))......))....))))))))).))..(....((.....(((.((..(.((((((((.(((..((((......(((((..((((((((.........)))))))).....)))))......))))..))).)))))))))..)).)))......))......)..(((((((((....)))))))))>........ Human cap-dependent 48S pre-initiation complex; 18S ribosomal RNA 6fec F 26 6.3 29401259 9606 cagacaccauggugcaccugacuccu .......................... .......................... Human cap-dependent 48S pre-initiation complex; Messenger RNA (26-MER) 6fec N 75 6.3 RF00005 URS0000326EAC_9606 29401259 0030533 0006412 9606 agcagaguggcgcagcggaagcgugcugggcccauaacccagaggucgauggaucgaaaccauccucugcuacca ....<<<..<<<.........>>>..<<<<.......>>>>.......<<<<.......>>>>.>>>........ (..((((..(((.........))).(((((.......))))).....(((((.......)))))))))..).... Human cap-dependent 48S pre-initiation complex; Transfer RNA (75-MER) 6ff4 2 60 3.4 RF00004 URS00003EE995_9606 29361316 0045131 0000348 0005686 9606 cgcuucucggccuuuuggcuaagaucaaguguaguaucuguucaucaguuuaauaucuga ............................................<.............>. ...............................................(........)... human Bact spliceosome core structure; U2 snRNA 6ff4 5 70 3.4 RF00020 URS0000118C49_9606 29361316 0000244,0000353 0005682,0046540 9606 ucugguuucucuucagaucgcauaaaucuuucgccuuuuacuaaagauuuccguggagaggaacaacucu .....<<<<<<.<<<........<<<<<<<<...........>>>>>>>>...>>>.>>>>>>....... .....(((((...((...((...((((((((.(.......).)))))))).))))...)))))....... human Bact spliceosome core structure; U5 snRNA 6ff4 6 95 3.4 RF00026 URS00001EC8D7_9606 29361316 0030621 0000244,0000353 0005688,0046540 9606 gugcucgcuucggcagcacauauacuaaaauuggaacgauacagagaagauuagcauggccccugcgcaaggaugacacgcaaauucgugaagcg <<<<<.<<....>>>>>>>.....................................<<...<<<.....>>>....>>................. .((((.((....))))))......................................((..((((.....)))..).))................. human Bact spliceosome core structure; U6 snRNA 6ff4 Z 48 3.4 29361316 9606 cgccgccaagguauguaucaagcuuacaaguuauguauuuacugaccu ................................................ ................................................ human Bact spliceosome core structure; pre mRNA 6ff7 2 60 4.5 RF00004 URS00003EE995_9606 29361316 0045131 0000348 0005686 9606 cgcuucucggccuuuuggcuaagaucaaguguaguaucuguucaucaguuuaauaucuga ............................................<.<<.<....>.>>>. ..............................................((........)).. human Bact spliceosome core structure; U2 snRNA 6ff7 5 70 4.5 RF00020 URS0000118C49_9606 29361316 0000244,0000353 0005682,0046540 9606 ucugguuucucuucagaucgcauaaaucuuucgccuuuuacuaaagauuuccguggagaggaacaacucu .....<<<<<<.<<<........<<<<<<<<...........>>>>>>>>...>>>.>>>>>>....... .....(((((..(((...((...((((((((.(.......).)))))))).)))))..)))))....... human Bact spliceosome core structure; U5 snRNA 6ff7 6 95 4.5 RF00026 URS00001EC8D7_9606 29361316 0030621 0000244,0000353 0005688,0046540 9606 gugcucgcuucggcagcacauauacuaaaauuggaacgauacagagaagauuagcauggccccugcgcaaggaugacacgcaaauucgugaagcg <<<<<.<<....>>>>>>>.....................................<<...<<<.....>>>....>>................. .((((.((....))))))......................................((..((((.....)))..).))................. human Bact spliceosome core structure; U6 snRNA 6ff7 Z 48 4.5 29361316 9606 cgccgccaagguauguaucaagcuuacaaguuauguauuuacugaccu ................................................ ................................................ human Bact spliceosome core structure; pre-mRNA 6fhh R 13 2.7 URS000080E01C_11320 11320 uauaccucugcuu ............. ............. Crystal structure of bat influenza A/H17N10 polymerase with viral RNA promoter bound to a 22-mer modified Pol II CTD peptide with serine 5 thiophosphorylated.; RNA (5'-R(*UP*AP*UP*AP*CP*CP*UP*CP*UP*GP*CP*UP*U)-3') 6fhh V 16 2.7 URS000080DFE6_11320 11320 aguaguaacaagaggg .<<....>>....... .((....))....... Crystal structure of bat influenza A/H17N10 polymerase with viral RNA promoter bound to a 22-mer modified Pol II CTD peptide with serine 5 thiophosphorylated.; RNA (5'-R(P*AP*GP*UP*AP*GP*UP*AP*AP*CP*AP*AP*GP*AP*GP*GP*G)-3') 6fhi R 13 2.8 URS000080E01C_11320 11320 uauaccucugcuu ............. ............. Crystal structure of bat influenza A/H17N10 polymerase with viral RNA promoter bound to a 19-mer serine 5 phosphorylated Pol II CTD peptide with a truncated linker.; RNA (5'-R(*UP*AP*UP*AP*CP*CP*UP*CP*UP*GP*CP*UP*U)-3') 6fhi V 16 2.8 URS000080DFE6_11320 11320 aguaguaacaagaggg .<<....>>....... .((....))....... Crystal structure of bat influenza A/H17N10 polymerase with viral RNA promoter bound to a 19-mer serine 5 phosphorylated Pol II CTD peptide with a truncated linker.; RNA (5'-R(P*AP*GP*UP*AP*GP*UP*AP*AP*CP*AP*AP*GP*AP*GP*GP*G)-3') 6fkr 1A 2872 3.2 RF02540,RF02541,RF00002 URS0000D56C3D_300852 29526712 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<.<..<<.....<<.......>>.....>>.........<<......>>....>.>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>>....<<<..>>>......>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<.<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>..>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)..)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...((((((((.(.((((((......)))).)))..))))))))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.((.((.((.....(.........).....)).........((......))...)).))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(......[..(((((..((.......((((((.(....).))))))....))..........].)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..((((.))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the dolphin proline-rich antimicrobial peptide Tur1A bound to the Thermus thermophilus 70S ribosome; 23S ribosomal RNA 6fkr 1B 120 3.2 RF00001 URS000080DFF2_300852 29526712 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the dolphin proline-rich antimicrobial peptide Tur1A bound to the Thermus thermophilus 70S ribosome; 5S ribosomal RNA 6fkr 1a 1500 3.2 RF00177,RF01959,RF01960 URS0000D56C52_300852 29526712 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<...<<<<<<......>>>>>.>...>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<.<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>.<.<<<......>>>.>>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>..>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((((((....))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...(((.....))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((.(((....))).))).(.(((......))))..)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the dolphin proline-rich antimicrobial peptide Tur1A bound to the Thermus thermophilus 70S ribosome; 16 ribosomal RNA 6fkr 2A 2872 3.2 RF02540,RF02541,RF00002 URS0000D56C3D_300852 29526712 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<.<.<<<<<<......>>>>.>>>..>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<.....<.........>.....>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<<..>>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((...((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...((((((((.(.((((((......)))).)))..))))))))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((...................))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))(((((((.......)))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((.((.(((((.(.........((((...(((.......(.(((.(....).)))).....))).............))))).)))))).).)))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..((((.))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the dolphin proline-rich antimicrobial peptide Tur1A bound to the Thermus thermophilus 70S ribosome; 23S ribosomal RNA 6fkr 2B 120 3.2 RF00001 URS000080DFF2_300852 29526712 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the dolphin proline-rich antimicrobial peptide Tur1A bound to the Thermus thermophilus 70S ribosome; 5S ribosomal RNA 6fkr 2a 1500 3.2 RF00177,RF01959,RF01960 URS0000D56C52_300852 29526712 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<....>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<.<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>.<..<<......>>..>>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<...<<<..<<<.....>>>>>>....>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>..>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>.........<.<<<<<<<........>>>>>>>>.........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((((((....))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...(((.....))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((...(((.(((....))).))).(..((......)).)..)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the dolphin proline-rich antimicrobial peptide Tur1A bound to the Thermus thermophilus 70S ribosome; 16 ribosomal RNA 6frk 2 76 3.7 RF00005 URS0000868532_9986 29567807 0030533 9986 guuuccguaguguagugguuaucacguucgccuaacacgcgaaagguccccgguucgaaaccgggcggaaacacca <<<<<<<..<<<..........>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..(((..........))).(((((.......))))).....(((((.......)))))))))))).... Structure of a prehandover mammalian ribosomal SRP and SRP receptor targeting complex; tRNA 6frk 5 3658 3.7 RF02540,RF02543 URS000086855C_9986 29567807 0003735 0005840 9986 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcggcccggcggaucuuucccgcgcgggggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucggccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcgcucuccccccucccggcgccgccggggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccgggggaggggccacgcgcgcgucccccgaagagggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcacacgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcgugagccgggcguggaauggagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagcggcgggggcggcgcgcgcgcgcgcccgcccccggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcugggucggucgucggccggcgccuagcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacauguuuuuucacugacccggugaggcgggggggcgagccccgaggggcucucgcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccggucccccgcgggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcacgccguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucgcugcgaucuauugaaagucagcccucgacacaaggguuugu ..........................<<<<<.....<......>......>>>>>...........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<<...<<<<<<<<<<<...>>>>>>>.>>>>.....>>>>>..<<<<<<<<<....<<<<<<<<........<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>...>>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<.......<<<<<<<.<<<.....<<<<<<<<<<<...<<<....<<<<<.<<....<<<<.<<<..<<<<<>>>>>>>>>>>>>>>>.>>>......>>>.>>>>>>>>>>>......>>>.>>>.>>>>...<<<<<<<..<<<<<<<<<<.<<<....<...<<.<<<.<<<<...<..<<<<<..>>>>>..>....>>>>.>>>>>.........>.>>>...>>>>>>>>>>....................<<<<<..<<<<<<...<<<<<.>>>>>.>>>>>>....<<<.<<<<.<<<<<<<<<<<<<<<<<<<<<<<<.<<<<....>>>>.>>>>>>>>>>.>>>>>>>>>>>.>>>....>>>>...>>>........<<<<<<<<.....>>>>>>>>........>>>>>.......>>.>>>>>....>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<....<<<<........>>>>......>>...<<....>>...<<<<<<<<....>>>>>>>>..<<<<<...<<<..<<<...(((..[[.>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<......<<<....>>><.<<.<<<<<<<............<<<<<<<<<...<<<....<<<....<<<...<<<.<.<.....>.>.>>>.>>>....>>>..>.>>...>>>>>>>...<<<<<<<<<........>>>>>>>>>...>>...>>>>>>>..>>>.<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<..........]]..))).......................<<<..>>>.......................>>>>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<<....<<.....<<<<<<.......>>>>>>.<<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<<<<<...>>>>>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<....<<<<<<<....>>>>>>>...<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<<<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>.>.>>>>>>>>>>>>.........>>>>>>>..>............>>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>.>>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<.<<<<<<<<<<<...<<<<<<.>>>>>>........>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<...<<.....<<<<....>>>>.....>>.>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>...>>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<<<<..>>>>>>>>>>...<<<<<.....<<<<..<<.<<<<<<....>>>>>>>>..............<<<<<<<<<<<.....>>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))].....<<<<<<<..<<<..)))))).>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<.]]]..>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.....<<<<<<<.<<..<<<.....<<.........<<<<<..<<<<..>>>>.>>>>>........>>....<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>..............>>>..>>>>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<....<<<<<..>>>>>...>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..(((((((((((.....)))))).))))....))))....((((((.((....((((((((.(.(....((((((((..({((((......)))))....[[(...).(((....}]])))...).)))))))).)))))))))...)).))))).).)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((......((((((((.(((.....(((((((((((...(((.(..(((((.((....((((.(((..((((()))))))))))))))).)))..)...))).)))))))))))......))).))).)))))..((((((((.((((.(((((.(((....(...((.(((.((((....(.(((((()))))))......)))).))))).........).)))...))))).))))....................(((((..(((((((..(((((.))))))))))))..((..(.((((..(((((((((((((((((((((((.((((....)))).)))))))))).))))))))))).))....).)))...).)..).....((((((((.....))))))))........)))))......))).)))))....)))...)))))))).[((((........))))((((((....(((((((((((((..(((..(((((........)))).)...)))...((....))...((((((((....))))))))..(((((...(((..(((....[[...[.)))..)))....))))).(((((((((.((((......))))))))))).))....)))))))))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((............(.((((((....(((....(((..(.(((...(((((.(.....).))))).))).)..)))..)).)....))))))...(((((((((........)))))))))....)...)))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........((..((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((.(((..........]...]]........................(((..))).......................)))))))))....))))))...((((((((.((......((((.((((....))))))))...))))))))))........))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...((..(.(((....))).....)....((.(((((((((...)))))))))))......))....))...(((((........)))))]]((((....(((.....((.((((....)))).))..((((....)))...(...((((((...(((((((((((((((((((((((...{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...))............))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((...((((((.))))))........)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.....(......((((....))))......)..))))..)))))..(((.........)))..........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.(((((((((.((((((((((..))))))))))...(((((.....((((..(..((((((....)))))).)..............(((((((((((.....)))))))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([(....(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(.(((..((((....{..))))..))))(((....)))..)]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a.))..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}..)))))..)).))...))))...)))).((((...((((.....}.......))))...))))..)))...).))))))......(((((......(((.....((..........((((..((((())))).)))).........))....((..((((....((((.(((((((......)))))))))))...))))..))..............))).....))))).(((((.(..(.......)..).......(((((((.((.....((((.(..(((((..)))))..)))))....))....)))).))).....))))).. Structure of a prehandover mammalian ribosomal SRP and SRP receptor targeting complex; 28S ribosomal RNA 6frk 7 120 3.7 RF00001 URS000002B0D5_9986 29567807 0003735 0005840 9986 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. Structure of a prehandover mammalian ribosomal SRP and SRP receptor targeting complex; 5S ribosomal RNA 6frk 8 156 3.7 RF00002 URS00004B2C76_9986 29567807 0003735 0005840 9986 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<.<<.....>>>.......<<<......>>.............>>>......>>>....<<<..>>><<<<<<<<.......>>>>>>>>.................... .........................................((((((.[[....[)))...]...(((......]].............)))......)))....((....))((((((((.......)))))))).................... Structure of a prehandover mammalian ribosomal SRP and SRP receptor targeting complex; 5.8S ribosomal RNA 6ft6 2 162 3.9 RF00002 URS0000D56C4B_559292 29519915 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauaaaauu .........................................<<<<<<<<<....>>>>.....<.<<<......>>..............>>>..>...>>>....<<.....>><<<<<<<<<....>>>>>>>>>......................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))......................... Structure of the Nop53 pre-60S particle bound to the exosome nuclear cofactors; 7S ribosomal RNA 6ft6 1 3058 3.9 RF02540,RF02543 URS000061F377_559292 29519915 0003735 0005840 559292 guuugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaaacuuuaaauauguaagaaguccuuguuugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuugggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggagugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ..........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<........<<.<<<<<<...>>>>>>.>>........>....<<<<<<<.<<<<<<<<<<<<<<<<<<<<.....<<<<......>>>>.(.......<<<......)>>>....>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<......<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<.....<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<..............>>>>.>>.>>....>>>>>>.>>>>>...<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<......<<......>>..<<.<<.<......<<<.<<<<<<.........................>>>>...<<<<.<<<....>>>.>>>>.....>>>>>.....>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<......<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>....>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..[[[..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<...............>>>>><<.<<<<<<<<<<<..>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>........<......<<..<...<<.....<<<<....>>>>.....>>.>.>>......>.<<<.<..........>.>>>.........<<..>>......>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<....>>>>>....(((((..[[[........(((((.{{((((..<<<<..<<<<<<<<..<<<<<<<<.......>>>>>>>>...<<<<<.....<<<.<..<<<........>>>................<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>...>>>>......<.<....<<<<<<...........>>>>>>.......<<<<<<<...<<<<<<.......>>>>>>......<......>.....>>>>>>>...<<<..<<<<.......>>>>..>>>.<<<....>>>...>.>..{......[[[...((((.>>>>>>)))).]]]........}...))))..}})))))...............<<<<...<<.......>>...>>>>...................<<<<...<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>.....>>>>......<<<<<<<....>>>.>>>>........]]].)))))....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<....<<<<<<<<<.]]]..>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<........<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>................>.>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<........>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ..........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))))....)))))))))))...)....(.(((((........))))).).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.(((((......(((((((((((((((((((((((.......(((((((......((((((....)))))).......))))))).....))))).))))))))))........(((....)))....)))))))).....))))).)))))..((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..(.((...(((((((....)))))))...).).)...(((..((.((........)))).)))....))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((.(((..(....(((.(((((((.......(........)......))))).....((.((((..)))).)).......)))))...)..))).))..((((.((.((.....)).)).))))....(((......)))...(((((((...((([[[...(.(((((.......(...........((.((((((((((.....{.((((....(...((.........))...).......(...((......)).)..))))...))))))))))))...........]]].).....)))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........((((((........))))))....))....))...(((((........)))))]]((((.((((((((...((((....)))...(.[.((((((...((((.((((((((((((((((((..{{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....))))..)))))))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((..)))))..)))))).))(...).......(((((((((...((.........))...(((((((....((((.....))))......))))))).]......(......(((.....((.....((((....)))).....))..)))......)..(................)...........(..).......)).))))))).)..))).)))))))..))))))....)).[..(((((..].)))))....(((((..(((.(......(((((.((((((..(((((.(((.((((..(((((((.(.....).)))))))....((((.....(((.(..(((........)))............]...((((((....))))))..))))..))))......)))).)))..)))))......(.(......((((...........)))).........(((((((....(((((.......)))))....................)))))))...(((....(.........)....)))((((....))).).).).......((.(((..((((.]]]]]]))))))).))..........))))..)))))))...............((((...((.......))...))))...................((((..(((((..(.(((((((......))))))..).).(.(.(.....).).).....)))))....))))......(((.(((....)))..))).....)..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}}.)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......((((...(.(.......((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).))))))...............)..)...))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Structure of the Nop53 pre-60S particle bound to the exosome nuclear cofactors; 25S ribosomal RNA 6ftg u 3662 9.1 RF02540,RF02543 URS000086853D_9986 29519914 0003735 0005840 9986 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcggcccggcggaucuuucccgcgcgggggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucggccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcgcucuccccccucccggcgccgccggggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccgggggaggggccacgcgcgcgucccccgaagagggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcacacgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcgugagccgggcguggaauggagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagcggcgggggcggcgcgcgcgcgcgcccgcccccggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcugggucggucgucggccggcgccuagcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacauguuuuuucacugacccggugaggcgggggggcgagccccgaggggcucucgcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccggucccccgcgggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcacgccguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..[[[..<<<<<...<<<<<<<<<<<...>>>>>>>.>>>>.....>>>>>..<<<<<<<<<....<<<<<<<<...<....<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>>..>>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<......<<<<<<<<.<<<.....<<<<<<<<<<<...<<<....<<<<<.<<....<<<<.<<<..<<<<<>>>>>>>>>>>>>>>>.>>>......>>>.>>>>>>>>>>>......>>>.>>>.>>>>>..<<<<<<<..<<<<<<<<<<.<<<....<...<<.<<<.<<<<......<<<<<..>>>>>.......>>>>.>>>>>.........>.>>>...>>>>>>>>>>....................<<<<<..<<<<<<<..<<<<<.>>>>>>>>>>>>....<<<.<<<<.<<<<<<<<<<<<<<<<<<<<<<<<.<<<<....>>>>.>>>>>>>>>>.>>>>>>>>>>>.>>>...>.>>>...>>>........<<<<<<<<.....>>>>>>>>........>>>>>.......>>.>>>>>....>>>...>>>>>>>>..<<<<........>>>><<<<<<...<<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<<....>>>>>>>>..<<<<<...<<<..<<<...(((.....>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>>.<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<............<<<<<<<<<...<<<....<<<..<.<<<...<<<.<.<.....>.>.>>>.>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<........>>>>>>>>>...>>...>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<........<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>....>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<..............))).......................<<<..>>>.......................>>>>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<<<<<...>>>>>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<....<<<<<<<....>>>>>>>...<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..{{{..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>............>>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<...............>>>>><<.<<<<<<<<<<<...<<<<<<.>>>>>>........>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<<.<<<<<<<<<<..>>>>>>>>>>...<<<<<.....<<<<..<<.<<<<<<<..>>>>>>>>>..............<<<<<<<<<<<.....>>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>><<<<....>>>>>>)))]......((((((..(((..>>>>>>.)))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]].....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<}}}.>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.....<<<<<<<.<<..<<<.....<<.........<<<<<..<<<<..>>>>.>>>>>........>>....<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>..............>>>..>>>>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<....<<<<<......>>>>>...>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..(((((((((((.....)))))).))))....))))....(((((..((....((((((((.(.(....((((((((..({((((......)))))....[[(...).(((....}]])))...).)))))))).)))))))))...))..)))))..)....((((.((........))).))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((......((((((((.((......(((((((((((...(((.(..(((((.((....((((.((...((((())))).)))))))))).)))..)...))).))))))))))).......)).))).)))))..((((((((.((((.(((((.(((....(...(.((((.((((....(.(((((()))))))......)))).))))).........).)))...))))).))))....................(((((..(((((((..(((((.))))))))))))..((.((.((((..(((((((((((((((((((((((.((((....)))).)))))))))).))))))))))).))....).)))...)))..).....((((((((.....))))))))........)))))......))).)))))....)))...)))))))).[((((........))))((((((....(((((((((((((..(((..(((((........)))).)...)))...((....))...((((((((....))))))))..(((((...(((..(((...[[[...[.)))..)))....))))).(((((((((.((((......))))))))))).))....)))))))))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....((.((....))).)((.(((((((............(.((((((....(((....(((..(.(((..(.((((.(.....).))))).))).)..)))..)).)....))))))...(((((((((........)))))))))....)...)))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.......(.....(((...((.........))...))).....(...((......)).).....)...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((..........]...]]].......................(((..))).......................)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...((..(.(((....))).....)....((.(((((((((...)))))))))))......))....))...(((((........)))))]]((((....(((.....(((((((....)))))))..((((....)))...(...((((((...((((((((((((((((((((((....{{..).))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...))............))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((...((((((.))))))........)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(..(((.....(((.....).)).....))))))))..)))))..(((.........)))..........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.(((((((((.((((((((((..))))))))))...(((((.....((((..((.((((((....))))))))..............(((((((((((.....)))))))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(.((((.......).)))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a.))..))).))))).....(((((..(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}..)))))..)).))...))))...)))).((((...((((.............))))...))))..)))...).).))))......(((((..((..(((.....((..........((((..((((())))).)))).........))....((..((((....((((.(((((((......)))))))))))...))))..))..............)))..)).))))).(.(((.(..(.......)..)....((.(((((((.((.....((((.(..(((((......)))))..)))))....))....)))).))).))..))))... Subtomogram average of OST-containing ribosome-translocon complexes from canine rough microsomal membranes; 28S ribosomal RNA 6ftg v 120 9.1 RF00001 URS000002B0D5_9986 29519914 0003735 0005840 9986 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. Subtomogram average of OST-containing ribosome-translocon complexes from canine rough microsomal membranes; 5S ribosomal RNA 6ftg w 156 9.1 RF00002 URS00004B2C76_9986 29519914 0003735 0005840 9986 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<.<<.....>>>.....(.<<<......>>.............>>>..)...>>>....<<<..>>><<<<<<<<.......>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))((((((((.......)))))))).................... Subtomogram average of OST-containing ribosome-translocon complexes from canine rough microsomal membranes; 5.8S ribosomal RNA 6fti q 76 4.2 RF00005 URS0000868530_9986 29519914 0030533 9986 gucuccguaguguagcgguuaucacguucgccuaacacgcgaaagguccucgguucgaaaccgggcggaaacacca <<.<<<<..<<<..........>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>.>>.... ((.((((..(((.....[....))).(((((.......))))).....(((((..]....))))))))).)).... Cryo-EM Structure of the Mammalian Oligosaccharyltransferase Bound to Sec61 and the Programmed 80S Ribosome; p-Site tRNA 6fti u 3662 4.2 RF02540,RF02543 URS000086853D_9986 29519914 0003735 0005840 9986 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcggcccggcggaucuuucccgcgcgggggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucggccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcgcucuccccccucccggcgccgccggggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccgggggaggggccacgcgcgcgucccccgaagagggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcacacgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcgugagccgggcguggaauggagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagcggcgggggcggcgcgcgcgcgcgcccgcccccggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcugggucggucgucggccggcgccuagcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacauguuuuuucacugacccggugaggcgggggggcgagccccgaggggcucucgcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccggucccccgcgggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcacgccguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..[[[..<<<<<...<<<<<<<<<<<...>>>>>>>.>>>>.....>>>>>..<<<<<<<<<....<<<<<<<<...<....<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>>..>>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<......<<<<<<<<.<<<.....<<<<<<<<<<<...<<<....<<<<<.<<....<<<<.<<<..<<<<<>>>>>>>>>>>>>>>>.>>>......>>>.>>>>>>>>>>>......>>>.>>>.>>>>>..<<<<<<<..<<<<<<<<<<.<<<....<...<<.<<<.<<<<......<<<<<..>>>>>.......>>>>.>>>>>.........>.>>>...>>>>>>>>>>....................<<<<<..<<<<<<<..<<<<<.>>>>>>>>>>>>....<<<.<<<<.<<<<<<<<<<<<<<<<<<<<<<<<.<<<<....>>>>.>>>>>>>>>>.>>>>>>>>>>>.>>>...>.>>>...>>>........<<<<<<<<.....>>>>>>>>........>>>>>.......>>.>>>>>....>>>...>>>>>>>>..<<<<........>>>><<<<<<...<<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<<....>>>>>>>>..<<<<<...<<<..<<<...(((.....>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>>.<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<............<<<<<<<<<...<<<....<<<..<.<<<...<<<.<.<.....>.>.>>>.>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<........>>>>>>>>>...>>...>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<........<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>....>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<..............))).......................<<<..>>>.......................>>>>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<<<<<...>>>>>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<....<<<<<<<....>>>>>>>...<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..{{{..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>............>>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<...............>>>>><<.<<<<<<<<<<<...<<<<<<.>>>>>>........>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<<.<<<<<<<<<<..>>>>>>>>>>...<<<<<.....<<<<..<<.<<<<<<<..>>>>>>>>>..............<<<<<<<<<<<.....>>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>><<<<....>>>>>>)))]......((((((..(((..>>>>>>.)))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]].....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<}}}.>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.....<<<<<<<.<<..<<<.....<<.........<<<<<..<<<<..>>>>.>>>>>........>>....<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>..............>>>..>>>>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<....<<<<<......>>>>>...>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..(((((((((((.....)))))).))))....))))....(((((..((....((((((((.(.(....((((((((..({((((......)))))....[[(...).(((....}]])))...).)))))))).)))))))))...))..)))))..)....((((.((........))).))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((......((((((((.((......(((((((((((...(((.(..(((((.((....((((.((...((((())))).)))))))))).)))..)...))).))))))))))).......)).))).)))))..((((((((.((((.(((((.(((....(...(.((((.((((....(.(((((()))))))......)))).))))).........).)))...))))).))))....................(((((..(((((((..(((((.))))))))))))..((.((.((((..(((((((((((((((((((((((.((((....)))).)))))))))).))))))))))).))....).)))...)))..).....((((((((.....))))))))........)))))......))).)))))....)))...)))))))).[((((........))))((((((....(((((((((((((..(((..(((((........)))).)...)))...((....))...((((((((....))))))))..(((((...(((..(((...[[[...[.)))..)))....))))).(((((((((.((((......))))))))))).))....)))))))))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....((.((....))).)((.(((((((............(.((((((....(((....(((..(.(((..(.((((.(.....).))))).))).)..)))..)).)....))))))...(((((((((........)))))))))....)...)))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.......(.....(((...((.........))...))).....(...((......)).).....)...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((..........]...]]].......................(((..))).......................)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...((..(.(((....))).....)....((.(((((((((...)))))))))))......))....))...(((((........)))))]]((((....(((.....(((((((....)))))))..((((....)))...(...((((((...((((((((((((((((((((((....{{..).))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...))............))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((...((((((.))))))........)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(..(((.....(((.....).)).....))))))))..)))))..(((.........)))..........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.(((((((((.((((((((((..))))))))))...(((((.....((((..((.((((((....))))))))..............(((((((((((.....)))))))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(.((((.......).)))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a.))..))).))))).....(((((..(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}..)))))..)).))...))))...)))).((((...((((.............))))...))))..)))...).).))))......(((((..((..(((.....((..........((((..((((())))).)))).........))....((..((((....((((.(((((((......)))))))))))...))))..))..............)))..)).))))).(.(((.(..(.......)..)....((.(((((((.((.....((((.(..(((((......)))))..)))))....))....)))).))).))..))))... Cryo-EM Structure of the Mammalian Oligosaccharyltransferase Bound to Sec61 and the Programmed 80S Ribosome; 28S rRNA 6fti v 120 4.2 RF00001 URS000002B0D5_9986 29519914 0003735 0005840 9986 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. Cryo-EM Structure of the Mammalian Oligosaccharyltransferase Bound to Sec61 and the Programmed 80S Ribosome; 5S ribosomal RNA 6fti w 156 4.2 RF00002 URS00004B2C76_9986 29519914 0003735 0005840 9986 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<.<<.....>>>.....(.<<<......>>.............>>>..)...>>>....<<<..>>><<<<<<<<.......>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))((((((((.......)))))))).................... Cryo-EM Structure of the Mammalian Oligosaccharyltransferase Bound to Sec61 and the Programmed 80S Ribosome; 5.8S ribosomal RNA 6ftj u 3662 4.7 RF02540,RF02543 URS000086853D_9986 29519914 0003735 0005840 9986 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcggcccggcggaucuuucccgcgcgggggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucggccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcgcucuccccccucccggcgccgccggggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccgggggaggggccacgcgcgcgucccccgaagagggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcacacgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcgugagccgggcguggaauggagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagcggcgggggcggcgcgcgcgcgcgcccgcccccggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcugggucggucgucggccggcgccuagcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacauguuuuuucacugacccggugaggcgggggggcgagccccgaggggcucucgcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccggucccccgcgggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcacgccguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..[[[..<<<<<...<<<<<<<<<<<...>>>>>>>.>>>>.....>>>>>..<<<<<<<<<....<<<<<<<<...<....<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>>..>>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<......<<<<<<<<.<<<.....<<<<<<<<<<<...<<<....<<<<<.<<....<<<<.<<<..<<<<<>>>>>>>>>>>>>>>>.>>>......>>>.>>>>>>>>>>>......>>>.>>>.>>>>>..<<<<<<<..<<<<<<<<<<.<<<....<...<<.<<<.<<<<......<<<<<..>>>>>.......>>>>.>>>>>.........>.>>>...>>>>>>>>>>....................<<<<<..<<<<<<<..<<<<<.>>>>>>>>>>>>....<<<.<<<<.<<<<<<<<<<<<<<<<<<<<<<<<.<<<<....>>>>.>>>>>>>>>>.>>>>>>>>>>>.>>>...>.>>>...>>>........<<<<<<<<.....>>>>>>>>........>>>>>.......>>.>>>>>....>>>...>>>>>>>>..<<<<........>>>><<<<<<...<<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<<....>>>>>>>>..<<<<<...<<<..<<<...(((.....>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>>.<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<............<<<<<<<<<...<<<....<<<..<.<<<...<<<.<.<.....>.>.>>>.>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<........>>>>>>>>>...>>...>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<........<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>....>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<..............))).......................<<<..>>>.......................>>>>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<<<<<...>>>>>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<....<<<<<<<....>>>>>>>...<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..{{{..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>............>>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<...............>>>>><<.<<<<<<<<<<<...<<<<<<.>>>>>>........>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<<.<<<<<<<<<<..>>>>>>>>>>...<<<<<.....<<<<..<<.<<<<<<<..>>>>>>>>>..............<<<<<<<<<<<.....>>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>><<<<....>>>>>>)))]......((((((..(((..>>>>>>.)))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]].....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<}}}.>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.....<<<<<<<.<<..<<<.....<<.........<<<<<..<<<<..>>>>.>>>>>........>>....<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>..............>>>..>>>>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<....<<<<<......>>>>>...>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..(((((((((((.....)))))).))))....))))....(((((..((....((((((((.(.(....((((((((..({((((......)))))....[[(...).(((....}]])))...).)))))))).)))))))))...))..)))))..)....((((.((........))).))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((......((((((((.((......(((((((((((...(((.(..(((((.((....((((.((...((((())))).)))))))))).)))..)...))).))))))))))).......)).))).)))))..((((((((.((((.(((((.(((....(...(.((((.((((....(.(((((()))))))......)))).))))).........).)))...))))).))))....................(((((..(((((((..(((((.))))))))))))..((.((.((((..(((((((((((((((((((((((.((((....)))).)))))))))).))))))))))).))....).)))...)))..).....((((((((.....))))))))........)))))......))).)))))....)))...)))))))).[((((........))))((((((....(((((((((((((..(((..(((((........)))).)...)))...((....))...((((((((....))))))))..(((((...(((..(((...[[[...[.)))..)))....))))).(((((((((.((((......))))))))))).))....)))))))))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....((.((....))).)((.(((((((............(.((((((....(((....(((..(.(((..(.((((.(.....).))))).))).)..)))..)).)....))))))...(((((((((........)))))))))....)...)))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.......(.....(((...((.........))...))).....(...((......)).).....)...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((..........]...]]].......................(((..))).......................)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...((..(.(((....))).....)....((.(((((((((...)))))))))))......))....))...(((((........)))))]]((((....(((.....(((((((....)))))))..((((....)))...(...((((((...((((((((((((((((((((((....{{..).))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...))............))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((...((((((.))))))........)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(..(((.....(((.....).)).....))))))))..)))))..(((.........)))..........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.(((((((((.((((((((((..))))))))))...(((((.....((((..((.((((((....))))))))..............(((((((((((.....)))))))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(.((((.......).)))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a.))..))).))))).....(((((..(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}..)))))..)).))...))))...)))).((((...((((.............))))...))))..)))...).).))))......(((((..((..(((.....((..........((((..((((())))).)))).........))....((..((((....((((.(((((((......)))))))))))...))))..))..............)))..)).))))).(.(((.(..(.......)..)....((.(((((((.((.....((((.(..(((((......)))))..)))))....))....)))).))).))..))))... Cryo-EM Structure of the Mammalian Oligosaccharyltransferase Bound to Sec61 and the Non-programmed 80S Ribosome; 28S rRNA 6ftj v 120 4.7 RF00001 URS000002B0D5_9986 29519914 0003735 0005840 9986 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. Cryo-EM Structure of the Mammalian Oligosaccharyltransferase Bound to Sec61 and the Non-programmed 80S Ribosome; 5S ribosomal RNA 6ftj w 156 4.7 RF00002 URS00004B2C76_9986 29519914 0003735 0005840 9986 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<.<<.....>>>.....(.<<<......>>.............>>>..)...>>>....<<<..>>><<<<<<<<.......>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))((((((((.......)))))))).................... Cryo-EM Structure of the Mammalian Oligosaccharyltransferase Bound to Sec61 and the Non-programmed 80S Ribosome; 5.8S ribosomal RNA 6fxc Aa 1539 6.76 RF00177,RF01959,RF01960 URS0000D56C2C_1280 28959035 0003735 0005840 1280 auggagaguuugauccuggcucaggaugaacgcuggcggcgugccuaauacaugcaagucgagcgaacggacgagaagcuugcuucucugauguuagcggcggacgggugaguaacacguggauaaccuaccuauaagacugggauaacuucgggaaaccggagcuaauaccggauaauauuuugaaccgcaugguucaaaagugaaagacggucuugcugucacuuauagauggauccgcgcugcauuagcuaguugguaagguaacggcuuaccaaggcaacgaugcauagccgaccugagagggugaucggccacacuggaacugagacacgguccagacuccuacgggaggcagcaguagggaaucuuccgcaaugggcgaaagccugacggagcaacgccgcgugagugaugaaggucuucggaucguaaaacucuguuauuagggaagaacauauguguaaguaacugugcacaucuugacgguaccuaaucagaaagccacggcuaacuacgugccagcagccgcgguaauacguagguggcaagcguuauccggaauuauugggcguaaagcgcgcguaggcgguuuuuuaagucugaugugaaagcccacggcucaaccguggagggucauuggaaacuggaaaacuugagugcagaagaggaaaguggaauuccauguguagcggugaaaugcgcagagauauggaggaacaccaguggcgaaggcgacuuucuggucuguaacugacgcugaugugcgaaagcguggggaucaaacaggauuagauacccugguaguccacgccguaaacgaugagugcuaaguguuaggggguuuccgccccuuagugcugcagcuaacgcauuaagcacuccgccuggggaguacgaccgcaagguugaaacucaaaggaauugacggggacccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaaaucuugacauccuuugacaacucuagagauagagccuuccccuucgggggacaaagugacagguggugcaugguugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuuaagcuuaguugccaucauuaaguugggcacucuaaguugacugccggugacaaaccggaggaagguggggaugacgucaaaucaucaugccccuuaugauuugggcuacacacgugcuacaauggacaauacaaagggcagcgaaaccgcgaggucaagcaaaucccauaaaguuguucucaguucggauuguagucugcaacucgacuacaugaagcuggaaucgcuaguaaucguagaucagcaugcuacggugaauacguucccgggucuuguacacaccgcccgucacaccacgagaguuuguaacacccgaagccgguggaguaaccuuuuaggagcuagccgucgaaggugggacaaaugauuggggugaagucguaacaagguagccguaucggaaggugcggcuggau .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<<<......................>>>>.>>>>>......<<........<<<<<<<..<<...<<<<<<<.<<<<.....<<<<<<....>>>>>>......>>>>......<<<.<...........>.>>>.......<....<...>...>..>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<.......<<<....>>>......>>>>....<<<<<<.......<.<<<<<<<........>>>>>>>.>........>>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<<..<<<.<<<<<<<.<<<<<<<<<.......<<<<<<.....>>>>>>.....>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>..>>>>>....<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<<....>>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<..<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<.......<<<<......<<<<<....>>>>>.....<<<<..>>>>....>>>.>..<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<..<.<<.........<<......>>.........>>>......<<<<.......>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>......<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>.......<..<.<<<..<<........>>..>>>>...>.....>>>>>.....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<..<<<<....<.<<<<..<<<..<<<...>>>.>>>.>>>>.>...>>>>..>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.... .....((((..[.[[[..)))).((((.(((((...((((((((....((.......(((..((..((........................))..)))))......(((.......(((((((..((...(((((((.((((.....((((((....))))))......))))......((.(.((........)).)).).........(......).....)))))))..))))))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....)))).......)).).....(.(((...((((......))).))))).)).))))).....((........((....)).......))......((((((...(.......(((((........))))).......)....))))))......(...([[[...(((((.....((.]]])).......))))))...)..)))))))))..........((([[...(.((((...(((.(((.(((.(((((((((.......((((((.....)))))).....)))))))..))))).)))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((....(...((((.........))))...).))))))......{...((((((..((((((((((((......))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..(((((..(((......((........))..........((((.((..(...(..((.(....(((((....)))))......((....))...).))...)).((.((....((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(.(...........((......))..........).).....((((.......))))........)))).....).).)))...))..))))....)).))))...)).)..))))).(...(((((((.....(((..((....((....))....))....))).....)))))))......(....(....((........))....)....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((..((((....(.((((..(((..(((...))).))).)))).)...))))..))))))..))).))))..).))...)..)..(((((((((....)))))))))}... The cryo-EM structure of hibernating 100S ribosome dimer from pathogenic Staphylococcus aureus; 16S ribosomal RNA 6fxc AA 2905 6.76 RF02540,RF02541,RF00002 URS000026DEF9_1280 28959035 0003735 0005840 1280 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The cryo-EM structure of hibernating 100S ribosome dimer from pathogenic Staphylococcus aureus; 23S ribosomal RNA 6fxc AB 115 6.76 RF00001 URS0000062A7E_1280 28959035 0003735 0005840 1280 ucuggugacuauagcaaggaggucacaccuguucccaugccgaacacagaaguuaagcuccuuagcgucgaugguagucgaacuuacguuccgcuagaguagaacguugccaggc <<<<<<<<<....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<......<<<.<<<<....>>>>.>>>......>>..>>>>>>>>>. (((.((.((....((((((((.....((((((...(.....)...))))..))....)))))).)).((.......((.((((....)))).)).......))..)).)).))). The cryo-EM structure of hibernating 100S ribosome dimer from pathogenic Staphylococcus aureus; 5S ribosomal RNA 6fxc Ba 1539 6.76 RF00177,RF01959,RF01960 URS0000D56C2C_1280 28959035 0003735 0005840 1280 auggagaguuugauccuggcucaggaugaacgcuggcggcgugccuaauacaugcaagucgagcgaacggacgagaagcuugcuucucugauguuagcggcggacgggugaguaacacguggauaaccuaccuauaagacugggauaacuucgggaaaccggagcuaauaccggauaauauuuugaaccgcaugguucaaaagugaaagacggucuugcugucacuuauagauggauccgcgcugcauuagcuaguugguaagguaacggcuuaccaaggcaacgaugcauagccgaccugagagggugaucggccacacuggaacugagacacgguccagacuccuacgggaggcagcaguagggaaucuuccgcaaugggcgaaagccugacggagcaacgccgcgugagugaugaaggucuucggaucguaaaacucuguuauuagggaagaacauauguguaaguaacugugcacaucuugacgguaccuaaucagaaagccacggcuaacuacgugccagcagccgcgguaauacguagguggcaagcguuauccggaauuauugggcguaaagcgcgcguaggcgguuuuuuaagucugaugugaaagcccacggcucaaccguggagggucauuggaaacuggaaaacuugagugcagaagaggaaaguggaauuccauguguagcggugaaaugcgcagagauauggaggaacaccaguggcgaaggcgacuuucuggucuguaacugacgcugaugugcgaaagcguggggaucaaacaggauuagauacccugguaguccacgccguaaacgaugagugcuaaguguuaggggguuuccgccccuuagugcugcagcuaacgcauuaagcacuccgccuggggaguacgaccgcaagguugaaacucaaaggaauugacggggacccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaaaucuugacauccuuugacaacucuagagauagagccuuccccuucgggggacaaagugacagguggugcaugguugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuuaagcuuaguugccaucauuaaguugggcacucuaaguugacugccggugacaaaccggaggaagguggggaugacgucaaaucaucaugccccuuaugauuugggcuacacacgugcuacaauggacaauacaaagggcagcgaaaccgcgaggucaagcaaaucccauaaaguuguucucaguucggauuguagucugcaacucgacuacaugaagcuggaaucgcuaguaaucguagaucagcaugcuacggugaauacguucccgggucuuguacacaccgcccgucacaccacgagaguuuguaacacccgaagccgguggaguaaccuuuuaggagcuagccgucgaaggugggacaaaugauuggggugaagucguaacaagguagccguaucggaaggugcggcuggau .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<<<......................>>>>.>>>>>......<<........<<<<<<<..<<...<<<<<<<.<<<<.....<<<<<<....>>>>>>......>>>>......<<<.<...........>.>>>.......<....<...>...>..>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<.......<<<....>>>......>>>>....<<<<<<.......<.<<<<<<<........>>>>>>>.>........>>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<<..<<<.<<<<<<<.<<<<<<<<<.......<<<<<<.....>>>>>>.....>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>..>>>>>....<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<......>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<..<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<.......<<<<......<<<<<....>>>>>.....<<<<..>>>>....>>>.>..<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<..<.<<.........<<......>>.........>>>......<<<<.......>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>......<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>.......<..<.<<<..<<........>>..>>>>...>.....>>>>>.....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<..<<<<....<.<<<<..<<<..<<<...>>>.>>>.>>>>.>...>>>>..>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.... .....((((..[.[[[..)))).((((.(((((...((((((((....((.......(((..((..((........................))..)))))......(((.......(((((((..((...(((((((.((((.....((((((....))))))......))))......((.(.((........)).)).).........(......).....)))))))..))))))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....)))).......)).).....(.(((...((((......))).))))).)).))))).....((........((....)).......))......((((((...(.......(((((........))))).......)....))))))......(...([[[...(((((.....((.]]])).......))))))...)..)))))))))..........((([[...(.((((...(((.(((.(((.(((((((((.......((((((.....)))))).....)))))))..))))).)))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((....(...((((.........))))...).))))))......{...((((((..((((((((((((......))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..(((((..(((......((........))..........((((.((..(...(..((.(....(((((....)))))......((....))...).))...)).((.((....((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(.(...........((......))..........).).....((((.......))))........)))).....).).)))...))..))))....)).))))...)).)..))))).(...(((((((.....(((..((....((....))....))....))).....)))))))......(....(....((........))....)....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((..((((....(.((((..(((..(((...))).))).)))).)...))))..))))))..))).))))..).))...)..)..(((((((((....)))))))))}... The cryo-EM structure of hibernating 100S ribosome dimer from pathogenic Staphylococcus aureus; 16S ribosomal RNA 6fxc BA 2905 6.76 RF02540,RF02541,RF00002 URS000026DEF9_1280 28959035 0003735 0005840 1280 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((((((......((((((((((.....(((..((((((((.((.(......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))(((((((......))))))).(((((((.(.........).))))).)).).....(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...((((((((....))))))))......(((((((((...(((((.....)((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))).)))))..)))))....((((((....[........))))))......(((((].[[[[)))))..)))......))..)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).......((((..((((..[...))))..)))).<.(.(........).).((((((..(.(((((((.(((((..(((...(((.....)))...)))...((....))..((((.....)))).....))))).)))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)<)))...(((.(((((........))))))))..).))))))))).(.(((....[)))...).]))))))......).))).((((((....(.(((....))).)(.(((((((...(((((((((.....(((...((((((((...((.........))...))))))))..)).).....)))).)))))..)))))))..)..((((((((((......))))))))))....(((......)))...((.(.(((...((([[[...(.((((((.....(.....((..((((.(((((.....{.(..(....(...(...........)...).........................)..)...))))).)))).))...........]]].)...))))))))))...)))).)).((((((...)))))).....))))))(.(((((((.((......(((((.((....))])))))...)).)))))))..).....))))))(......((....((((((.......))))))((((....(((...((...((((((...((.....)).))))))....[[((((..(.(.(((...(((....)))...)))..))....(((((........)))))]]((((((............((...((((....(((((..((...(..............{...............(((...((..(((((((.((.....))))))))).......))...))).................................)....))..)))))(..).....))))..)).......))))))))))..)).....((......))..))).(((.......)))..))))...(((....((((((((.((..(....(.......(((((....(.[..).....)))))(((((((.(((......))).)))))))(...).......(((((((((.>.(...........)...(((((((.....(((....))).......))))))).]((((..((..(((((((..(((...((...(((((.............)))))...))...))))))))..)))).(((((.....))))).........(..........(((((.......)))))..).......))))...)).))))))).)..))).)))))))).))).)).....)..[..(((((.....>].)))))..((((((((.(((.((......((((.((((((..(((((.(((((((((.((((.(((((...(....[...........((..(.(.........(.(((...]))).)......).)............)).......)...))))).)))).....(.((((((.....)))))))......)))))))))..)))))..(((......[)))((((((..........]))))))([.(....((((((.(.(((((.........)))))...).((][.[[[))....))))))....((((..(((...{..)))..)))).(((....))).).]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}..))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))((((....)))....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))...))))))). The cryo-EM structure of hibernating 100S ribosome dimer from pathogenic Staphylococcus aureus; 23S ribosomal RNA 6fxc BB 115 6.76 RF00001 URS0000062A7E_1280 28959035 0003735 0005840 1280 ucuggugacuauagcaaggaggucacaccuguucccaugccgaacacagaaguuaagcuccuuagcgucgaugguagucgaacuuacguuccgcuagaguagaacguugccaggc <<<<<<<<<....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<......<<<.<<<<....>>>>.>>>......>>..>>>>>>>>>. (((.((.((....((((((((.....((((((...(.....)...))))..))....)))))).)).((.......((.((((....)))).)).......))..)).)).))). The cryo-EM structure of hibernating 100S ribosome dimer from pathogenic Staphylococcus aureus; 5S ribosomal RNA 6fyx 1 75 3.5 RF00005 URS00002CB170_4932 30475211 0030533 0006412 4932 agcgccgunncgcagnggaagcgcncagggcucaunacccugaunnnnucggaucgnaaccgngcggcgcuacca <<<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((....[..)))).(((((.......))))).....(((((..]....)))))))))))).... Structure of a partial yeast 48S preinitiation complex with eIF5 N-terminal domain (model C1); tRNAi 6fyx 2 1780 3.5 RF01960,RF01959,RF00177 URS0000E60BB2_284590 30475211 0003735 0005840 284590 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacauggauaucugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacuccuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaacuggagggcaagucuggugccagcagccgcgguaauuccagcuccaguagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggucugguuguccggucgguuuuucaaccggaucuuuccuucuggcuaaccuguacuccuugugggugcaggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcgaaagcucgaauauauuagcauggaauaauggaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauacngucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuucuuaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacncaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaggguugcuggcacuugccgguugacucuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacangucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgaguacaaccuuggccgagaggucuggguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacnagnaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgnccgucgcuaguaccgauugaauggcuuagugaggccucaggauuugcuuagagaagggggcaacuccaucucagagcgaagaaucuggucaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguagguganccugcggaaggaucauua ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[......{{....[[[[...............<<.....<<.<<.......>>.>>......>>........<<<<<..<<....>>..>>>>>[..[.(((((......<<<<<<<.<<<....>>>....<<......>>)))))].....]...<<<<..<<<.....>>>.>>>>..].]]]...}}....]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<<<<<<..........>>>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[<........{{...[[[.{{....<<<<<<<<<<<.....<<>>.....>>>>>>>>>>>.....<<<<<......<<..<<.......>>..>>......>>>>>....<<<<<.<<.......<<...<.......>..<<<....>>>....>>......>>.>>..>>>.........[[[..(((((((......>>>>>>>..))))))).]]].....}}....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>......<<<....>>>..>>>>..>.>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<.<.......>>>>>>>>>>>..>>>...<<..>.>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<......<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<<<<<<<<....<<<.<<<<......>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<<<<<<<<....>>>>>>.>>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>...>.>>>>>>>.......>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<<.<<<<....>>>>.>>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<..<...<<<<<<..........................>>>>>>...>..>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))((((.((.(((...(.(....(.....(((.(((..((....((....((..........))...)){))......(((.......(((..((...(...(.((............{...((.....((.(((.....))).))......))........(((((..((....))..)))))(.(.(.((((......[[[[[[[.(((....))).....(......).)))))..)...).(}((((..((((..).))).)))))..).))...)).)..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).)))))......).).....((.((((.(..((....))..).))))..))....(.(((.(...........)).))......)..(((.([[....(.((((.....((..]])).......)))))).)))..))).))))))..{......((({....(.(.((...(((.((....(((((((((((......()......)))))))))))......((((.......(.((.........)).).......)))).....((.((.((.......(...((.......)).(((....))).....)......)).))...)).........(((..(..(.(((.....]]]]]]].))).)..).))).....))....((..((..(...((((..((..(.((((.....((........))........)))))...)).......((....))...))))..)..))...))...)))...)).)....((((..........((((.........)))).......))))......<...(((.((.(((...(((((((.((.(.......))))))))))...)))...((...}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((..(((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....((..(.(((....)))..(.((......)))....)..))....(((((.((..((((..((((((((((((....)))))).))))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))..))).(...(((((((......((.....(((.((((....)))).)))....)).......)))))))......(....((((((..........))))))....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..((((..(...(((((...(....................)...)))))...)..))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>........ Structure of a partial yeast 48S preinitiation complex with eIF5 N-terminal domain (model C1); 18S ribosomal RNA 6fyx 3 31 3.5 30475211 4932 cucuaacuauaaaaaugucucuucucucucu ............................... ............................... Structure of a partial yeast 48S preinitiation complex with eIF5 N-terminal domain (model C1); mRNA (31-MER) 6fyy 1 75 3.02 RF00005 URS0000E60B6B_4932 30475211 0030533 0006412 4932 agcgccgunncgcagnggaagcgcncagggcucaunacccugaunnnnucggaucgnaaccgngcggcgcuacca <<<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((....[..)))).(((((.......))))).....(((((..]....)))))))))))).... Structure of a partial yeast 48S preinitiation complex with eIF5 N-terminal domain (model C2); tRNAi 6fyy 2 1780 3.02 RF01960,RF01959,RF00177 URS0000E60BB2_284590 30475211 0003735 0005840 284590 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacauggauaucugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacuccuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaacuggagggcaagucuggugccagcagccgcgguaauuccagcuccaguagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggucugguuguccggucgguuuuucaaccggaucuuuccuucuggcuaaccuguacuccuugugggugcaggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcgaaagcucgaauauauuagcauggaauaauggaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauacngucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuucuuaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacncaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaggguugcuggcacuugccgguugacucuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacangucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgaguacaaccuuggccgagaggucuggguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacnagnaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgnccgucgcuaguaccgauugaauggcuuagugaggccucaggauuugcuuagagaagggggcaacuccaucucagagcgaagaaucuggucaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguagguganccugcggaaggaucauua ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{.....[[[{...............<<.....<<.<<<.....>>>.>>......>>........<<<<<..<<....>>..>>>>>{..[[.((((......<<<<<<<.<<<....>>>....<<......>>))))]].....}...<<<<..<<<.....>>>.>>>>..}.]]]....}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<<<<<<..........>>>>>>>.>>>......<<..<...........>..>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..))))))]]]].........[[[<<.......{{...[[[.{{....<<<<<<<<<<<.....<<>>.....>>>>>>>>>>>....<<<<<<......<<<.<<.......>>.>>>......>>>>>>...<<<<<.<<.......<<...<.......>..<<<....>>>....>>......>>.>>..>>>.........[[[..(((((((......>>>>>>>..))))))).]]].....}}....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>......<<<....>>>..>>>>..>.>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<.<.......>>>>>>>>>>>..>>>...<<.>>.>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<......<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<<<<<<<<....>>>>>>.>>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>.......>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<<.<<<<....>>>>.>>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<..<...<<<<<<..........................>>>>>>...>..>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))((((.((.(((...(.(....(.....(((.(((..((....((....((..........))...)){))......(((.......(((..((...(...(.((............{...((.....((.(((.....))).))......))........(((((..((....))..)))))(.(.(.((((......[[[.[[[.(((....))).....(......).)))))..)...).(}((((..((((..).))).)))))..).))...)).)..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).)))))......).).....((.((((.(..((....))..).))))..))....(.(((.(...........)).))......)..(((.([[....(.((((.....((..]])).......)))))).)))..))).))))))..{......((({....(.(.((...(((.((....(((((((((((.....(()).....)))))))))))......((((.........((.........)).........)))).....((.((.((.......(...((.......)).(((....))).....)......)).))...)).........(((..(..(.(((.....]].]]]].))).)..).))).....))....((..((..(...((((..(((.(.((((.....((........))........)))))..))).......((....))...))))..)..))...))...)))...)).)....((((..........((((.........)))).......))))......<...(((.((.(((...(((((((.((.(.......))))))))))...)))...((..}.))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((..(((((......((........))........(.(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....((..(.(((....)))..(.((......)))....)..))....(((((.((..((((..((((((((((((....)))))).))))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).))))))..)).)))..))).(...(((((((......((.....(((.((((....)))).)))....)).......)))))))......(....((((((..........))))))....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(..(((((((.(((..((((..(...(((((...(....................)...)))))...)..))))..))).))))))).)..)).))))...).))...)..)..(((((((((....)))))))))>........ Structure of a partial yeast 48S preinitiation complex with eIF5 N-terminal domain (model C2); 18S ribosomal RNA 6fyy 3 31 3.02 30475211 4932 cucuaacuauaaaaaugucucuucucucucu ............................... ............................... Structure of a partial yeast 48S preinitiation complex with eIF5 N-terminal domain (model C2); mRNA (31-MER) 6g19 X 14 3.68 URS0000E60BBD_10879 30449722 10879 caagccgaggagag .............. .............. CryoEM structure of the MDA5-dsRNA filament with 74-degree helical twist; RNA (5'-R(P*CP*AP*AP*GP*CP*CP*GP*AP*GP*GP*AP*GP*AP*G)-3') 6g19 Y 14 3.68 URS0000E60BDD_10879 30449722 10879 cucuccucggcuug .............. .............. CryoEM structure of the MDA5-dsRNA filament with 74-degree helical twist; RNA (5'-R(P*CP*UP*CP*UP*CP*CP*UP*CP*GP*GP*CP*UP*UP*G)-3') 6g1s X 15 3.93 URS0000E60B84_10879 30449722 10879 uccaugcgcaugacg ............... ............... CryoEM structure of the MDA5-dsRNA filament with 87-degree helical twist; RNA (5'-R(P*UP*CP*CP*AP*UP*GP*CP*GP*CP*AP*UP*GP*AP*CP*G)-3') 6g1s Y 15 3.93 URS0000E60BC3_10879 30449722 10879 cgucaugcgcaugga ............... ............... CryoEM structure of the MDA5-dsRNA filament with 87-degree helical twist; RNA (5'-R(P*CP*GP*UP*CP*AP*UP*GP*CP*GP*CP*AP*UP*GP*GP*A)-3') 6g1x X 15 3.93 URS0000E60B84_10879 30449722 10879 uccaugcgcaugacg ............... ............... CryoEM structure of the MDA5-dsRNA filament with 91-degree helical twist; RNA (5'-R(P*UP*CP*CP*AP*UP*GP*CP*GP*CP*AP*UP*GP*AP*CP*G)-3') 6g1x Y 15 3.93 URS0000E60BC3_10879 30449722 10879 cgucaugcgcaugga ............... ............... CryoEM structure of the MDA5-dsRNA filament with 91-degree helical twist; RNA (5'-R(P*CP*GP*UP*CP*AP*UP*GP*CP*GP*CP*AP*UP*GP*GP*A)-3') 6g7z A 132 3.33595 RF01807 URS0000E60B83_5793 31427457,24821772 0008380 5793 cauccgguaucccaagacaucuucggguggguugggaaguaucauggcuaaucaccaugaugcaaucggguugaacacuuaauuggguuaaaacggugggggacgaucccguaacauccguccuaacggcga ...<<<<...<<<<<..<<<<....>>>>..>>>>>..<<<<<<<<<...(((.>>>>>>>>>..>>>>.......................<<<<..<<<...)))>>>.......>>>><<....>>... ...((((...(((((..((((....))))..)))))..(((((((((...[[[.)))))))))..)))).......................((((..(((...]]]))).......))))((....))... Lariat-capping ribozyme with a shortened DP2 stem loop; Lariat-capping ribozyme 6g7z B 54 3.33595 URS0000E60B9B_5793 31427457,24821772 5793 gacugcacggcccugccucagguguguucaaugaacagucguuccgaaaggaag <<<<<.........<<<<.>>>>............>>>>>.<<<<....>>>>. (((((.........((((.))))............))))).((((....)))). Lariat-capping ribozyme with a shortened DP2 stem loop; Lariat-capping ribozyme 6g90 1 327 4.0 RF00488 URS0000D77947_4932 29995849 0030627 0000395 0005685 4932 auacuuaccuuaagauaucagaggagaucaagaaguccuacugaucaaacaugcgcuuccaagaaggacguuaagcauuuaucauugaacguucauugaacauugaugcaaacuccuuggucacacacacgcggaaggcguguuugcugacgucccuuguuucaaucauugguuaacugauuuuuggggcccuuuguucuucugagaagugacaccaauugguguuaggggagcuggggccuuucaaaannnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnuuuuggaaggucuuggucggguggaucuuauaauuuuugauuua ...........<<<<<<<<<<<<<<..........>>>>.>>>>><<<<<<<<<.<<<<....<<<<<.<<<..<<<<.<.<<<.<<<<..>>>>.>>>.....>>>>>.>>>>>>>>...............>>>>>>>>>>>>><<.<<<<<<<<.<<<<<<<..<<<<<<..>>>>>>..>>>>>>>........<<<<<.>>>>>.<<<<<<<..>>>>>>>.>>>>><<<<<<<<<<<<<<<<<..................................>>>>>>>>>>>>>>>>>>>..>>>>>>>>............... ...........((((((((((((((..........)))).)))))((((((.((.((((....(((((.(((..(((((..(((.((((())))).))).....))))).))))))))...(........)..)))))).))))))(..(((((((.((...(((..((..((()))..))..)))...)........(((((.))))).(((((((())))))))).))))((...(.((((.(((((..................................))))).)))).)...))))..).))))))............... Prespliceosome structure provides insight into spliceosome assembly and regulation (map A2); U1 snRNA,U1 snRNA,U1 snRNA,U1 snRNA,U1 snRNA 6g90 2 143 4.0 RF00004 URS0000D77935_4932 29995849 0045131 0000348 0005686 4932 aaguguaguaucuguucuuuucaguguaacaacugaaaugaccuaggcucauacacauuuuuuggcaggacgggaagaggagacgucgcgacccucgcagagucguucuugacuuggucgcuugauguuucuucuucccguuc ...................<<<<<<......>>>>>><<<<<<..>>.>>>>................<<<<<<<<<<.<<<<<<<<<<<<.<<.....<<<<<<....>>>>>>>>>>>>..>>>>>>>>.>>>>>>>>>>. ...................((((((......))))))((((((())).))))...............(.(((((((((.((((((((((((.((......(((((....))))).))))))..)))))))).))))))))).) Prespliceosome structure provides insight into spliceosome assembly and regulation (map A2); U2 snRNA 6g90 I 38 4.0 29995849 4932 agguaugucuaacuucucuuauuuacaaacaaaaucaa ...................................... ...................................... Prespliceosome structure provides insight into spliceosome assembly and regulation (map A2); Yeast UBC4 pre-mRNA (mutant) 6gaw BA 1549 3.2 RF02541,RF02540 URS000022E3AE_9823 30089917 0003735 0005840 9823 accaaagcuagcucaacauacuaaacaaauacaaaaauacaccaaaauaaaauaaaacauucaccuaacauuaaaguauaggagauagaaauuuuuauccugacgcuauagagauaguaccguaagggaaagaugaaagaauaaaauaaaaguaaaaaaaagcaaagauuaccccuucuaccuuuugcauaaugguuuaaccagaaaaaaucuaacaaagagaacuuuagcuagauaccccgaaaccagacgagcuacccaugagcaguuuaaaagaaccaacucaucuauguggcaaaauagugagaagacuuguagguagaggugaaaagccuaacgagccuggugauagcugguuguccgagaaagaauuuuaguucaaccuuaaaaauaccccaaaaacccuaaauuccaauguauuuuuaagagauagucuaaaaagguacagcuuuuuagaaacggauacaaccuugacuagagaguaaaaucuuaauacuaccauaguaggccuaaaagcagccaucaauugagaaagcguuaaagcucaacaaauucaccaacauaaucccaaaaacuaauaacaaacuccuagcccaauaccggacuaaucuauugaaacauagaagcaauaauguuaauaugaguaacaagaagccuuucuccucgcacacgcuuacaucaguaacuaauaauauacugauaauuaacaaccaauaaaccaaaacaacacuaaaacguuuauuaauuacauuguuaacccaacacaggagugcaccaaggaaagauuaaaagaaguaaaaggaacucggcaaacacaaaccccgccuguuuaccaaaaacaucaccucuagcauuacuaguauuagaggcaaugccugcccagugacaccaguuuaacggccgcgguauucugaccgugcaaagguagcauaaucacuuguucuccaaauaaggacuuguaugaauggccacacgaggguuuuacugucucuuacuuccaaucagugaaauuaaccuucccgugaagaggcgggaauaaaaaaauaagacgagaagacccuauggagcuuuaauuaacuauuccaaaaguuaaacaacuaacuuaacauggacuagcaauuucgguuggggugaccucggaguacaaaaaacccuccgagugauuuuaaucuagacaaaccagucaaaauaaccauaacaucacuuauugauccaaaauuuugaucaacggaacaaguuacccuagggauaacagcgcaauccuguucuagaguuccuaucgacaauaggguuuacgaccucgauguuggaucaggacacccaaauggugcaaccgcuauuaaagguucguuuguucaacgauuaaaguccuacgugaucugaguucagaccggagcaauccaggucgguuucuaucuauuauaaauuucucccaguacgaaaggacaagagaaaugggaccaaccucacaaacgcgucucagagauaauuaaugauuuaaucuuaaccuaauuaacucauaauaaauccagcccuagaacagggcaca <<.<......<<<<.......................................<......>.................<<.....>>..............>>.>>.............<<....>>...................>....>>...........<<<.......>>>...<.<........>.>..<<<<<........<<<<<.<..<<....>>...>.>>>>>..<<.<...<<<<.<.....<<<.<<<<<..<<<......>>>...<<<..<<<<........>>>>.>>>....>>>>>.>>>...<<<.....>>>......>.>>>>......>.>>..<<<<<.....<<<<....>>>>...<<<<<<<<<<<.....<<........>>.....>>>>>>>>>>>......<<<<<<<<<......>>>>>>>>>...<<......>>....<<<<.<<<...................<....<<<.........>>>....>.......<<<......>>>........................................>>>>>>>........>>>>>...<<<<<......>>>>>.........>>>>>.<......<<..<<<<..>>>><<<<.<<<<........<<<<<....<<....>>..>>>>>......<<<..<<<<<<<.................>>>>>>>.......>>>.....<<......>>.>>>>....>>>>..<<<<....<<<<<<<.<<...............<<<<<<<<..<<<.........>>>...<<<<<<.............>>>>>>....<<<.<<<..<<<<<....>>>..>>>>><<<<<<......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>....>>.>>>>>>......>>.>>>>>>>.>>>>.>>.....>.....<<<<<........>>>>>.......<<<.<<<.<<......<<<<.<<<<<<..<<<<..<<<.<<<<.<<<<<<......>>>>>>....>>>>.>>>.>>>>..<<<<.....>>>><<<<<<...........>>>>>>.<<<<....<<...<<<......>>>...>>.........>>>>..........<<<....>>>............>>>>..>>>>>>.......<<<..<.<<<<<<...<<.......>>...>>>>>>...>.>>.>.......<<<<<..<<<<<..<<.<<<<<<......>>>>>>...>>.<<<<<.....>>>>>.....>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>>>>.<<.<<<<<<<.................>>>>>>><<<<<...............>>>>>.<<<...<<<<.<............>..>>>>...>>>.>>.........<<<<.......>>>>... ((.(...(..((((.......................................(...[..)........(..(.....((.]...))....)..)......)).)).............((....))....)..............)....))...........(((.......))).[.(.(........).)..(((((........(((((.(..((....))...).)))))..((.(...((((.(.....(((.((((((.((......[.))...(((..((((.......{)))).)))..).))))).))).(.(((.....)))...)..).))))......).))..(((((.....((((....))))...(((((((((((.....((........)).....)))))))))))......(((((((((......)))))))))...((......))....((((.(((...................(.(..(((.........)))..).)....(..(((......)))).......................................)))))))........)))))...(((((......))))).........))))).(......((..((((..))))(((..((((......(.(((((....((....))..)))))......(((..(((((((...........(..)..))))))).......))).)...((......)).)))).....)))..((((....(((((((.((..(....(.......((((((((.].((.........))....((((((.............))))))....(((.(((..(((((....)))..)))))(((((........)))))........((..........(((((.......)))))..)..)....)))....)).))))))..)..))).))))))).)))).)).....)..{..(((((.....]}.))))).......(((.(((.((......((((.((((((..((((..(((.((((.((((((......))))))....)))).))).))))..(((......[)))((((((..........]))))))((((((..)((.(.(((...[..))))..)).........))))..........(((....))).....)].....))))..))))))......((((..(.(((.((...((.......))...)).)))...).)).).)......((((.((((((..((.((((((......))))))...)).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..}.))..)))))).((.(((((((......(....).....)))))))(((((...(.(.....).).))))).(((....(((.................)))....))).)).........((((.......))))... Unique features of mammalian mitochondrial translation initiation revealed by cryo-EM. This file contains the complete 55S ribosome.; 16S ribosomal RNA, mitochondrial 6gaw AA 960 3.2 RF00177,RF01959 URS00000CFF65_9823 30089917 0003735 0005840 9823 acagguuugguccuggccuuucuauuaauucuuaauaaaauuacacaugcaaguauccgcgccccggugagaaugcccuccagaucuuaaagaucaaaaggagcagguaucaagcacaccuauaacgguagcucauaacgccuugcucaaccacacccccacgggaaacagcagugauaaaaauuaagccaugaacgaaaguuugacuaaguuauauuaauuagaguugguaaaucucgugccagccaccgcggucauacgauuaacccaaauuaauagauccacggcguaaagaguguuuaagaaaaaaaaucacaauagaguuaaauuauaacuaagcuguaaaaagcccuaguuaaaauaaaauaacccacgaaagugacucuaauaauccugacacacgauagcuaggacccaaacugggauuagauaccccacuaugccuagcccuaaacccaaauaguuacauaacaaaacuauucgccagaguacuacucgcaacugccuaaaacucaaaggacuuggcggugcuucacauccaccuagaggagccuguucuauaaucgauaaaccccgauagaccuuaccaacccuugccaauucagccuauauaccgccaucuucagcaaacccuaaaaaggaacaauaguaagcacaaucauagcacauaaaaacguuaggucaagguguagcuuauggguuggaaagaaaugggcuacauuuucuacauaagaauauccaccacacgaaaguuuuuaugaaacuaaaaaccaaaggaggauuuagcaguaaaucaagaauagagugcuugauugaauaaggccaugaagcacgcacacaccgcccgucacccuccucaagcauguaguaauaaaaauaaccuauauucaauuacacaaccaugcaagaagagacaagucguaacaagguaagcauacuggaaagugugcuuggauuacc ..((((..<<<<<<.)))).<<<<<<<<<..<<<<<<<<....<<<.<<<..<<....>>......<<......<<<<<...<<<<<...>>>>>...>>>.>>.<<<....<<...<<<......>>>..>>......>>>..<.....>.>>.<<<....>>>.....>>>>>>..........<<....<<<<....>>>>..>>...>>.>>>>>>...<.<<<<<<.....(((.....((.>>>)).......)))..>>>.>..>>>>>>>>>.....<<<((.....<<<<...<<..............<<<<<<....<..<<<<<<.<<<......>>>..>>>>>>..>...........<<....>>.>>>>>>......>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<<.....))..>>>>>>>.>>>.<<<........<<....>>......>>>..>>>>>><<<<<.<<<<<<<...<<..<<<<<..<<<<<<<<<<.....<<........>>..........<<<<<<<..........<<<.<<<..<<<<<<.......<<..<<<<<....>>>.......>>..>>......<<.....>>..........>>>...>>>>>>>>>...>>>>>>>..>>.>>>>>>>>.....<<<<.....>>>>...........<....<<<<<<<......>>>>>>>....>.....>>>>>.....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<...<<<.<<..<<<<<..<<<<<...<<<<.....>>>>..>>>>>.....>>>>>..>>.>>>....>.>>...>.....<<<<<<<<<....>>>>>>>>>........ [.[[[[..(((((..]]]]](((((((((..((((((((..(.(((.(((..((....))......(((.....(((((...((((.....))))...))).)).(((....((..((((......))).)))......)))..(.....)))).(((....))).....)))))))......(..((...(((((....)))).))).).)).))))))...(.((([[[.....(((.....((.]]])).......)))..))).)..))))))))).....((([[...(.((((...((..............(((((((......((((((.((........))..))))))......).....(.((....)))))))))......))...))))....((((((...((...((((.........))))...))))))))......{...(((((((.....]]..))))))))))).(((........((....))......)))...)))))(((((.(((((((...((..(((((..((((((((((.....((........))..........(((((((..(......).((.(((...((((((.(....((..(((((....))).......))..))......((.....))......).).)))...)).)))))....)))))))..)).)))))))).(...((((.....))))..(.....)..(....(((((((......)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(...(((.((..(((((..(((((...((((.....))))..))))).....)))))..)).)))....).))...)..)..(((((((((....)))))))))}....... Unique features of mammalian mitochondrial translation initiation revealed by cryo-EM. This file contains the complete 55S ribosome.; 12S ribosomal RNA, mitochondrial 6gaw AV 71 3.2 URS0000D77905_9606 30089917 9606 aguaaggucagcuaaauaagcuaucgggcccauaccccgaaaauguugguuauacccuucccguacuacca <<<<.<<..<<<<.....>>>>.<<<<<.......>>>>>....<..<<......>>..>>>.>>>>.... ((((.((..((((.....)))).(((((.......)))))....(..((......))..))).)))).... Unique features of mammalian mitochondrial translation initiation revealed by cryo-EM. This file contains the complete 55S ribosome.; P-site fMet-tRNAMet, mitochondrial 6gaw AX 17 3.2 30089917 9606 augacccaccaaucaca ................. ................. Unique features of mammalian mitochondrial translation initiation revealed by cryo-EM. This file contains the complete 55S ribosome.; MT-CO3 mRNA, mitochondrial 6gaz AA 960 3.1 RF00177,RF01959 URS00000CFF65_9823 30089917 0003735 0005840 9823 acagguuugguccuggccuuucuauuaauucuuaauaaaauuacacaugcaaguauccgcgccccggugagaaugcccuccagaucuuaaagaucaaaaggagcagguaucaagcacaccuauaacgguagcucauaacgccuugcucaaccacacccccacgggaaacagcagugauaaaaauuaagccaugaacgaaaguuugacuaaguuauauuaauuagaguugguaaaucucgugccagccaccgcggucauacgauuaacccaaauuaauagauccacggcguaaagaguguuuaagaaaaaaaaucacaauagaguuaaauuauaacuaagcuguaaaaagcccuaguuaaaauaaaauaacccacgaaagugacucuaauaauccugacacacgauagcuaggacccaaacugggauuagauaccccacuaugccuagcccuaaacccaaauaguuacauaacaaaacuauucgccagaguacuacucgcaacugccuaaaacucaaaggacuuggcggugcuucacauccaccuagaggagccuguucuauaaucgauaaaccccgauagaccuuaccaacccuugccaauucagccuauauaccgccaucuucagcaaacccuaaaaaggaacaauaguaagcacaaucauagcacauaaaaacguuaggucaagguguagcuuauggguuggaaagaaaugggcuacauuuucuacauaagaauauccaccacacgaaaguuuuuaugaaacuaaaaaccaaaggaggauuuagcaguaaaucaagaauagagugcuugauugaauaaggccaugaagcacgcacacaccgcccgucacccuccucaagcauguaguaauaaaaauaaccuauauucaauuacacaaccaugcaagaagagacaagucguaacaagguaagcauacuggaaagugugcuuggauuacc ..((((..<<<<<<.)))).<<<<<<<<<..<<<<<<<<....<<<.<<<..<<....>>......<<......<<<<<...<<<<<...>>>>>...>>>.>>.<<<....<<...<<<......>>>..>>......>>>..<.....>.>>.<<<....>>>.....>>>>>>..........<<....<<<<....>>>>..>>...>>.>>>>>>...<.<<<<<<.....(((.....((.>>>)).......)))..>>>.>..>>>>>>>>>.....<<<((.....<<<<...<<..............<<<<<<....<..<<<<<<.<<<......>>>..>>>>>>..>..........<<<....>>>>>>>>>......>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<<.....))..>>>>>>>.>>>.<<<........<<....>>......>>>..>>>>>><<<<<.<<<<<<<...<<..<<<<<..<<<<<<<<<<.....<<........>>..........<<<<<<<..........<<<.<<<..<<<<<<.......<<..<<<<<....>>>.......>>..>>......<<.....>>..........>>>...>>>>>>>>>...>>>>>>>..>>.>>>>>>>>.....<<<<.....>>>>...........<....<<<<<<<......>>>>>>>....>.....>>>>>.....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<...<<<.<<..<<<<<..<<<<<...<<<<.....>>>>..>>>>>.....>>>>>..>>.>>>....>.>>...>.....<<<<<<<<<....>>>>>>>>>........ [.[[[[..(((((..]]]]](((((((((..((((((((..(.(((.(((..((....))......(((.....(((((...((((.....))))...))).)).(((....((..((((......))).)))......)))..(.....)))).(((....))).....)))))))......(..((...(((((....)))).))).).)).))))))...(.((([[[.....(((.....((.]]])).......)))..))).)..))))))))).....((([[...(.((((...((..............(((((((......((((((.((........))..))))))......).....(.((....)))))))))......))...))))....((((((...((...((((.........))))...))))))))......{...(((((((.....]]..))))))))))).(((........((....))......)))...)))))(((((.(((((((...((..(((((..((((((((((.....((........))..........(((((((..(......).((.(((...((((((.(....((..(((((....))).......))..))......((.....))......).).)))...)).)))))....)))))))..)).)))))))).(...((((.....))))..(.....)..(....(((((((......)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(...(((.((..(((((..(((((...((((.....))))..))))).....)))))..)).)))....).))...)..)..(((((((((....)))))))))}....... Unique features of mammalian mitochondrial translation initiation revealed by cryo-EM. This file contains the 28S ribosomal subunit.; 12S ribosomal RNA, mitochondrial 6gaz AV 71 3.1 URS0000D77905_9606 30089917 9606 aguaaggucagcuaaauaagcuaucgggcccauaccccgaaaauguugguuauacccuucccguacuacca <<<<.<<..<<<<.....>>>>.<<<<<.......>>>>>....<..<<......>>..>>>.>>>>.... ((((.((..((((.....)))).(((((.......)))))....(..((......))..))).)))).... Unique features of mammalian mitochondrial translation initiation revealed by cryo-EM. This file contains the 28S ribosomal subunit.; P-site fMet-tRNAMet, mitochondrial 6gaz AX 17 3.1 30089917 9606 augacccaccaaucaca ................. ................. Unique features of mammalian mitochondrial translation initiation revealed by cryo-EM. This file contains the 28S ribosomal subunit.; MT-CO3 mRNA, mitochondrial 6gbz A 2789 3.8 RF02540,RF02541 URS00004B0F34_83333 29883607 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggaggcugauaccgcccaagaguucauaucgacggcgguguuuggcacgucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>>.>>...............<<....>>....>>.........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<......<<...<<<.<<<<...<<.<<<.......>>>..>>...>>>>.>>>..>>.......>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<.........>>>...>>........<<........>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<.<......>.>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....[[[...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>.>........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<<.<<....>>..>>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.<<.....<<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>>.<<<....<<<<<<...<<.......>>...>>>>>>.....>>.>..>>...>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]].>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....(((((((...[.......)))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...).)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((...(((((((((.....(((...(((.((((......(...........).......)))).)))..)).).....)))))).)))...))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.......(((((..((..(............)...))......(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((..........))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((...(((...(((....)))...)))...)))..(((((........)))))]]((((((((((.((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...{))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...)).....)))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.[..).....)))))((((((.....(((...(((((..)}))))...)))...))))))(...).......(((((((((...((.........))...(((((((.....(((....))).......))))))).]((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((.....(((((.((((((..(((((.(((.(((((.(((((((((((..(((.(.........(((((...((........(..(((....)))..).....)).............)))))).)))..)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))(.((...(((((((...(((((.........))))).....((.[.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))).((((....(((((...(.(......))...))))).....))).)..))...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). 50S ribosomal subunit assembly intermediate state 5; 23S ribosomal RNA 6gbz B 119 3.8 RF00001 URS000080E133_83333 29883607 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>> ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))) 50S ribosomal subunit assembly intermediate state 5; 5S ribosomal RNA 6gc0 A 2729 3.8 RF02540,RF02541 URS00004B0F34_562 29883607 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggagucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>>.>>...............<<....>>....>>.........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.......<...<<<.<<<<...<..<<<.......>>>...>...>>>>.>>>..>........>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<.........>>>...>>........<<........>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<..<......>..>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....[[[...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>.>........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.......<<<<<<.<......>..>>>>>>.......>>>>>>>>>..>>>>><<<<<<.......>>>>>>................................>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<........<<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<.]]]..>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<.........>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...(((..((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))........(((((((...[.......)))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....)).........((((.....)))).............).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.((.......))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((....((.((((..........................)))).))...)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.......(((((..((..(.............)..))......(...((......)).).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((.(.(......).).))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))....((((....)))).....)))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((.......(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...((((.((.....(((....))).......)).)))).}((((.(((..(.(((((..(((........(((((..((....))...)))))........))))))))...))))(((((.........)))))................................))))...)).))))))).)...)).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(.....(((((.((((((..(((((.(((.(((((.(((((((((((.((((.(.........(((((...((.......(((((.(....).)))))....)).............)))))).)))).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))(.((...(((((((...(((((.........))))).....((.[.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.(...]]]]...)))))))).....)}......))))..)))))))....)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(.(....((((.............))))....).).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). 50S ribosomal subunit assembly intermediate state 4; 23S ribosomal RNA 6gc0 B 119 3.8 RF00001 URS000080E133_562 29883607 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca .<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. ((((((((((.....((.(((((....(((.(((.............)))...)))...)))))..)).((.......(.((((((...)))))).).......))...)))))))))) 50S ribosomal subunit assembly intermediate state 4; 5S ribosomal RNA 6gc4 A 2586 4.3 RF02540,RF02541 URS00004B0F34_83333 29883607 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcgucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccgguguaaacggcggccguaacuauaacgguccuaagguagcgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<......<<...<<<.<<<<......<<.........>>.......>>>>.>>>..>>.......>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<..>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<..<......>..>>>>>....>>>>>><<<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>.>>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<....<<..>>.....>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<....>>>>>.<<<<<.......>>>>>...............>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<..<<<......<<<<.<<<....>>>.>>>>...>>>............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<.......>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>...]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<....<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>..>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))((((((......)))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((........))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.((.......))...)..))))))......).))..((((((....((((......)))).((((((((...(((((((((.....((....(((.(((......(.............).......))).)))...).).....)))))).)))...))))))).)...((((.(((((......))))).))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(.(((..((()))..))).).))...........]]].)...))))))))))...)))))))((((..............))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((...(((...(((....)))...)))...)))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))(...((((....(((((((((((.((.....))))))))))..)))...[))))....)(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((.(((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..((....)))))(((.(.........).)))........()....))))...)).).))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.((..((......((((.(((((((.((((..((..(((((.(((((((((((.((((.(.........(..((...((........(..(((....)))..).....)).............))..)).)))).)))))))))))...(((.((((((.....)))))))))....)))))..))...))))..(.(.......).)((((((...........))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((...(((..{.)))...)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}.....)))))..))))))...))...))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...((((((((((.}}}..)))))..)))))...)))).)))))....((....((((.............))))....))..))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..(.....(((((....)))))....)...))))).))).....))..).))))))))). 50S ribosomal subunit assembly intermediate state 3; 23S ribosomal RNA 6gc4 B 119 4.3 RF00001 URS000080E133_83333 29883607 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>> ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((.(((((...))))).)).......))...)))))))))) 50S ribosomal subunit assembly intermediate state 3; 5S ribosomal RNA 6gc8 A 2897 3.8 RF02540,RF02541 URS00004B0F34_83333 29883607 0003735 0005840 83333 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<<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<.>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<.........>>>...>>........<<........>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<..<<....>>..>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>.>........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<....<.<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.......<<<<<<.<<....>>..>>>>>>.......>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<.<<<<<..<<<...........<<<<<...<<......<<<<<<<<....>>>>>>>>...>>.............>>>>>..>>>..>>>>>.>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<.<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>...>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..((((((((.((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))((((((......)))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((.(((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))))))).)))...))))...)....(((((((...[.......)))))))......(((((].[[[[)))))..)))......))..)))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((.(((.)))..))...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((...(..(.............)..)..........(((......)))..)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((.(..........).))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((...(((...(((....)))...)))...)))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(............(((((....(....).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...((((.((.....(((....))).......)).))))..((((.(((..((((((...(((........(((((..((....))...)))))........))).))))..)))))(((((.........)))))........((.(......).(((((.......)))))..)..)....))))...)).)))))))....))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((..(((.(.........(((((...((.......(((((((....)))))))....)).............)))))).)))..)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))(.((...(((((((...(((((.........))))).....((.[.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). 50S ribosomal subunit assembly intermediate - 50S rec*; 23S ribosomal RNA 6gc8 B 119 3.8 RF00001 URS000080E133_83333 29883607 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<........<<<<<<<...>>>>>>>........>>...>>>>>>>>>> ((((((((((.....((((((((....(((.(((...(.....)...)))...)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))) 50S ribosomal subunit assembly intermediate - 50S rec*; 5S ribosomal RNA 6gjz X 14 4.06 URS0000E60BBD_10879 30449722 10879 caagccgaggagag .............. .............. CryoEM structure of the MDA5-dsRNA filament in complex with AMPPNP; RNA (5'-R(P*CP*AP*AP*GP*CP*CP*GP*AP*GP*GP*AP*GP*AP*G)-3') 6gjz Y 14 4.06 URS0000E60BDD_10879 30449722 10879 cucuccucggcuug .............. .............. CryoEM structure of the MDA5-dsRNA filament in complex with AMPPNP; RNA (5'-R(P*CP*UP*CP*UP*CP*CP*UP*CP*GP*GP*CP*UP*UP*G)-3') 6gkh X 15 4.06 URS0000E60BB0_10879 30449722 10879 gucaagccgaggaga ............... ............... CryoEM structure of the MDA5-dsRNA filament in complex with ADP-AlF4; RNA (5'-R(P*GP*UP*CP*AP*AP*GP*CP*CP*GP*AP*GP*GP*AP*GP*A)-3') 6gkh Y 15 4.06 URS0000E60BD6_10879 30449722 10879 ucuccucggcuugac ............... ............... CryoEM structure of the MDA5-dsRNA filament in complex with ADP-AlF4; RNA (5'-R(P*UP*CP*UP*CP*CP*UP*CP*GP*GP*CP*UP*UP*GP*AP*C)-3') 6gkm X 14 3.87 URS0000E60BBD_10879 30449722 10879 caagccgaggagag .............. .............. CryoEM structure of the MDA5-dsRNA filament in complex with ATP (10 mM); RNA (5'-R(P*CP*AP*AP*GP*CP*CP*GP*AP*GP*GP*AP*GP*AP*G)-3') 6gkm Y 14 3.87 URS0000E60BDD_10879 30449722 10879 cucuccucggcuug .............. .............. CryoEM structure of the MDA5-dsRNA filament in complex with ATP (10 mM); RNA (5'-R(P*CP*UP*CP*UP*CP*CP*UP*CP*GP*GP*CP*UP*UP*G)-3') 6gpg B 13 2.894 URS000080E1F4_32630 30047865 32630 cgacgcuagcguc ............. ............. Structure of the RIG-I Singleton-Merten syndrome variant C268F; RNA (5'-R(*CP*GP*AP*CP*GP*CP*UP*AP*GP*CP*GP*UP*CP*G)-3') 6gpg C 13 2.894 URS000080E1F4_32630 30047865 32630 gacgcuagcgucg ............. ............. Structure of the RIG-I Singleton-Merten syndrome variant C268F; RNA (5'-R(*CP*GP*AP*CP*GP*CP*UP*AP*GP*CP*GP*UP*CP*G)-3') 6gq1 1 3223 4.4 RF02540,RF02543 URS000061F377_559292 29886014 0003735 0005840 559292 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........................<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<.<<<<<<<<<<<<<<<<<<<<<.....<<<<......>>>>.(.......<<<......)>>>....>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<......>>>..................................<<<<<.<<<<<.......<<............>>..<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<....<.<<<<<<....>>>>>>>......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<<..<<....>>.>.>>>.>>>.>>....>>>>>>.>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>(><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<..<.<<<<<...<<<<<.....>>>>>.>>>>>.>..>>>..>>.>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>).<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<......<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>....>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><<<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>.>>.....>>>>>><<<....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>.........<<<<..........>>>>.....>>....>>....<<<<........>>>>.))<<<<.<<<<<<<.....<<<....>>>...<...<<<<<<...<<<<.<<<<<<<<<<<<<<<<<<..{{{..>>>>>>....<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>.....<<<<<<<<....>>>>>>>>>>>>.>.>>>>>>>.>>>>.........>>>>>>...>......>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<.<<<<<<<<<<<....>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>...>>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<<<<<.<<<..........<<.<<......................>>.>>.>>>.>>>.>>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<....<<.......>>....>>>>>...>>..>>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.<.....>.>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<.<..<<<<........>>>>..>>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.(((((.......(..............)..((((((((((((((.((.(((((.......(((((((......((((.(....).)))).......))))))).....)))))..)).))))))........(((....)))....)))))))).....))))).))))).<((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((...((((....))))....))))).((((((((....(....)....))).))).))....)))))).))))))...(((...((((((.....((((((((((.((((...(((((((....)))))))...)<)))....((..((.((.......A)))).))...).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).).(((((((((...(((.(((((((.....(((....(((..(.((((....(((((.....)))))..)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).)...((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))((((((((.(.((......(((..((((....)))).)))...)).))))))).)).....))))))((.....((.....((((((.......))))))((((.....((.(..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........(((((..........)))))....))....))...(((((........)))))]]((((..(((((.(...((((....)))...(.[[((((((...((((.(((((((((((((((((....{{...)))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....).))..))).)))).)))..)).....((......)).).)).((((.....))))..))))..((((.....(((((((.((..(............(((((....(.[..).....)))))((.((((((((((.(...)))))..)))))).))(...).......(((((((((.>.((.........))....((((((....((((.....))))......))))))..].(((.(((..((((((.(...(......((((....))))......).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).)))))))....))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(.(((((((((..((((..........((..(..(......)............)..)).))).).).)))))))).)....((((.....((((..((((........))))..........]]...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...(((..(((.(...{..))))..))).((......)).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(...(((((....((.......))....)))).)...).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a.))..))).))))).....(((((((..((((.(.(((((......(....).....))))).)(((((...(.((....(((((((((.}}...))))..)))))...)).)..))))).((((...((((.....}.......))))...)))).))))....)))))))........((((((.(((.((....((.(........(.(((((..).)))).).....))).......((.(((...(((((.(..(((......)))..).))))).))).)).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Cryo-EM reconstruction of yeast 80S ribosome in complex with mRNA, tRNA and eEF2 (GMPPCP/sordarin); Saccharomyces cerevisiae S288C 35S pre-ribosomal RNA (RDN37-1), miscRNA 6gq1 3 121 4.4 RF00001 URS000055688D_559292 29886014 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<<............>>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(.(((..((....)).))).).....))))))))))))))). Cryo-EM reconstruction of yeast 80S ribosome in complex with mRNA, tRNA and eEF2 (GMPPCP/sordarin); 5.8S ribosomal RNA 6gq1 4 158 4.4 RF00002 URS00001BF64E_559292 29886014 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Cryo-EM reconstruction of yeast 80S ribosome in complex with mRNA, tRNA and eEF2 (GMPPCP/sordarin); 5S ribosomal RNA 6gq1 2 1776 4.4 RF01960,RF01959,RF00177 URS0000D77925_559292 29886014 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucau ...<<<<<...[[[[>>>>>[[[..((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[..................<.....<<.<<.......>>.>>......>.........<<<<<..<<....>>..>>>>>[...((((((......<<<<<<<<<<<....>>>..............)))))).....]...<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>...<<<..>>>.....]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<<<<<<<<<....>>>>>>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..)))))).]]].........[[[{{.......{{...[[[.{{....<<<<<<.<<<<<............>>>>>.>>>>>>.....<<<<.........<<<.........>>>.........>>>>....<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[[..((((((((....>>>>>>>>.)))))))).]]].....}}....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<........>>......>.>>>>>>..>>.......<<....>>...>>>>..>>.>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<...>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<......>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<.<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<.....<<<<<<....<<<.<<<<......>>...<<<......>>>...>>.>>>....<<<<..<<..<.<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>.>.>>....<<<<<<.....>>>>>>........>>>>....>>>.>>>.......>>>>>.....>.>>>>>...>..>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<.<<<<..............>>>>.>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>.........<<<<<<<<<....>>>>>>>>>....... ...((((..[.[[[..))))((...((((((...(.....((.....(((.(((..((....((.....(..........)....)){))......(((.......(((..((..((....(((..................(.....((.(.(......)).))......).........(((((...(.....)..)))))(.(.((((((......[[[.[[[[(((....))).....(......).)))))).)...).(.((((...(.(..)..)..)))))...)))...))))..))).(((....((.....((((((((.......)))))))).))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)......).....(.(((((.(.(((....))).).)))).).)....(.(.(.(...........))..)......)..((((([[....(.((((.....((..]])).......))))))))))..))))))..))..{......((({{...(.(.((...(((.((....((((((.(((((............))))).))))))....((((((........(((..(....).)))........))))))...((((..((.......((..(.........).(((.....)))....))......))..)..))).........(....((((.(((....]]]].]]].))).))))...).....))...(((.(((..(...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)..)))..))..))))...)).)....((((((....(...((((.........))))...).))))))......<....((.((.(((...(((((((.(((...))))))))))...)))...((..}}))...))...}.)).)))).(((......((((....))))....)))...]]].](((((.(((((((..((.((((((..(((.((((((.......(........)...........((((..(....(((((........((.(((........))).))......)))))....(.((.......(((((....(((.(((((....)))..(.((......)))...)).)))....(((...((..(.((..(((((..(.(((....))).)....)))))..)).).))..(.(((((.......)))))....)....)))....))).)).........)))......)..))))...)).)))).))).(...(((((((......((.....((..(.((....)).)..))....)).......)))))))......(....((((((..........))))))....)..)..))))))....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.(((((.((.(((..(.((..(...(((((((.(((....(.....).....))).)))))))...)..)).)..))).)).))))))..)).))))...).))...)..)..(((((((((....)))))))))>...... Cryo-EM reconstruction of yeast 80S ribosome in complex with mRNA, tRNA and eEF2 (GMPPCP/sordarin); 18S ribosomal RNA 6gq1 AX 76 4.4 RF00005 URS000011107D_559292 29886014 0030533 0006412 559292 gcggauuuagcucaguugggagagcgccagacugaagaucuggagguccuguguucgauccacagaauucgcacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((.(((..((((.....[..)))).(((((.......))))).....(((((..]....)))))))).))).... Cryo-EM reconstruction of yeast 80S ribosome in complex with mRNA, tRNA and eEF2 (GMPPCP/sordarin); Transfer RNA - Phe 6gqb 1 3223 3.9 RF02540,RF02543 URS000061F377_559292 29886014 0003735 0005840 559292 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........................<<<<<<.....<......>......>>>>>.>...{.....<<....>>..<<<<<......<<.....>>.....>>>>>..[[[...........<<.<<<<<<...>>>>>>.>>.............<<<<<<.<<<<<<<<<<<<<<<<<<<<<.....<<<<......>>>>.(.......<<<......)>>>....>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((.<<<<<<<)))))..]]]....}.............................<<....>>...............<<<......>>>..................................<<<<<.<<<<<.........................<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<<..>>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<.....<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>...<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<..<.<<<<<..<<<<<<.....>>>>>>>>>>>.>..>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<......<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>....>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><<<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>.>>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<..........>>>>>....>>....>>....<<<<........>>>>.))<<<<.<<<<..<<....<<<....>>>...<...<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>...>.....>>....>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<....>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>.<.<<..<<<..<<<<<<.<..<<<....<<<<<....>>>>.>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>.>..>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<<..<.<<<...........<.<<......................>>.>..>>>.>...>>>>>>>>>>...<<<<<.....<<<<..<<<<........>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..(((..>>>>>>>)))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>..>>........<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>.....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>......<<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>.><<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. 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Cryo-EM reconstruction of yeast 80S ribosome in complex with mRNA, tRNA and eEF2 (GDP+AlF4/sordarin); Saccharomyces cerevisiae S288C 35S pre-ribosomal RNA (RDN37-1), miscRNA 6gqb 3 121 3.9 RF00001 URS000055688D_559292 29886014 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<<............>>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.......((((...(....)...))).)........)))))).)).(((((.......(((((..((....)).))))).....))))).))))))))). Cryo-EM reconstruction of yeast 80S ribosome in complex with mRNA, tRNA and eEF2 (GDP+AlF4/sordarin); 5S ribosomal RNA 6gqb 4 158 3.9 RF00002 URS00001BF64E_559292 29886014 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.......<<<......>>..............>>>......>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Cryo-EM reconstruction of yeast 80S ribosome in complex with mRNA, tRNA and eEF2 (GDP+AlF4/sordarin); 5.8S ribosomal RNA 6gqb 2 1776 3.9 RF01960,RF01959,RF00177 URS0000D77925_559292 29886014 0003735 0005840 559292 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Cryo-EM reconstruction of yeast 80S ribosome in complex with mRNA, tRNA and eEF2 (GDP+AlF4/sordarin); 18S ribosomal RNA 6gqb AX 76 3.9 RF00005 URS000011107D_559292 29886014 0030533 0006412 559292 gcggauuuagcucaguugggagagcgccagacugaagaucuggagguccuguguucgauccacagaauucgcacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).(((((.......))))).....(((((..]....)))))))))))).... Cryo-EM reconstruction of yeast 80S ribosome in complex with mRNA, tRNA and eEF2 (GDP+AlF4/sordarin); Transfer RNA - Phe 6gqv 1 3223 4.0 RF02540,RF02543 URS000061F377_4932 29886014 0003735 0005840 4932 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Cryo-EM recosntruction of yeast 80S ribosome in complex with mRNA, tRNA and eEF2 (GMPPCP); 25S ribosomal RNA 6gqv 3 121 4.0 RF00001 URS000055688D_4932 29886014 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....(.((((...(....)...))).)....)...)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Cryo-EM recosntruction of yeast 80S ribosome in complex with mRNA, tRNA and eEF2 (GMPPCP); 5S ribosomal RNA 6gqv 4 158 4.0 RF00002 URS00001BF64E_4932 29886014 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((.(((....))).)))))..................... Cryo-EM recosntruction of yeast 80S ribosome in complex with mRNA, tRNA and eEF2 (GMPPCP); 5.8S ribosomal RNA 6gqv 2 1776 4.0 RF01960,RF01959,RF00177 URS0000D77925_4932 29886014 0003735 0005840 4932 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...((((..[.[[[..))))((((.((((((...(.....((.....(((.(((..((....((.....(..........)....)){))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[[[[[..(((....))).....(......).)))))).)...).(.((((...(((..).))..)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)......).....(((((((.(..((....))..).)))).)))......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((.....(((((.(((((.....().....))))).))))).......((((........(((..(....).)))........)))).....(((((.((.......((..((.......))..((.....)).....))......)).))..))).........(....((((.(((......]]]]]].))).))))...).....))...(((..((.((...((((..((..((((((.(...((........)).......)))))))..)).......((....))...))))..)).))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((...)))))))))))..)))...((..}}))...))...}.)))))))..((......((((....))))....))....]]].]((.(..(((((((...(.((((((..(((.((((((.......(........)...........((((..(....(.((......(..((.(((........))).))....)..)).)....(.((....(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..(......(.....(.((......)).).......)......).))..(.(((((.......)))))....)..)))))....))).))).....)..)))......)..))))...)).)))).))).(...(((((((......((.....((..(.((....)).)..))....)).......)))))))......(....((((((..........))))))....)..)..))))))....(.((((((.......)))))).)......)....))))))).)..))..(.(..((.(..((((.((..(.(((((.((.(((..(.((..(...((.(((..((..................))..))).))...)..)).)..))).)).))))))..)).))))...).))...)..)..(((((((((....)))))))))>...... Cryo-EM recosntruction of yeast 80S ribosome in complex with mRNA, tRNA and eEF2 (GMPPCP); 18S ribosomal RNA 6gqv AY 76 4.0 RF00005 URS000011107D_4932 29886014 0030533 0006412 4932 gcggauuuagcucaguugggagagcgccagacugaagaucuggagguccuguguucgauccacagaauucgcacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).(((((.......))))).....(((((..]....)))))))))))).... Cryo-EM recosntruction of yeast 80S ribosome in complex with mRNA, tRNA and eEF2 (GMPPCP); Transfer RNA - Phe 6gsj 13 1500 2.96 RF00177,RF01959,RF01960 URS000080E226_300852 29931292 0003735 0005840 300852 uuguuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgcguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggacac ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<......>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>.....<......>....>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((........))).)))))......(((......((((((((..((...(((((((.(((((....(((((......))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(.....(((.....)))......)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((((..((((((......)))))).................))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet and cognate tRNAThr in the A-site; 16S ribosomal RNA 6gsj 1K 74 2.96 RF00005 URS00004A988A_83333 29931292 0030533 0006412 83333 gcugauauagcucagnggagagcgcacccuuggunagggugaggucggcagnucgacucugccuaucagcacca <<<..<...<<<<......>>>>.<<<<<<.....>>>>>>......<<<<.......>>>>..>..>>>.... .(.(......(((......)))..(((((.......)))))......((((.......))))....).)..... Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet and cognate tRNAThr in the A-site; tRNAThr 6gsj 2K 77 2.96 RF00005 URS000041AF00_83333 29931292 0030533 0006412 83333 cgcggggnggagcagccugguagcucgucgggnucauaacccgaagnucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet and cognate tRNAThr in the A-site; tRNAfMet 6gsj 3K 72 2.96 RF00005 URS00005B2D1B_83333 29931292 0030533 0006412 83333 gcugauauagcucaguagagcgcacccuugguaagggugaggucggcaguucgaaucugccuaucagcacca <<<<.....<<<<....>>>>.<<<<<<.....>>>>>>.......<<<.......>>>.....>>>>.... (((..(...(.((....)).).(((((.......)))))........((.......))....)..))).... Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet and cognate tRNAThr in the A-site; tRNAThr 6gsj 4K 18 2.96 URS0000D77948_83333 29931292 83333 gguaaaaaugaccaaaaa .................. .................. Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet and cognate tRNAThr in the A-site; RNA (27-MER) 6gsj 1H 2850 2.96 RF02540,RF02541,RF00002 URS0000868533_300852 29931292 0003735 0005840 300852 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...<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.....>>>>>>.>>....<<<<<.....<......>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....<<.....>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...............>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<.........>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<......<.<..<<<<<<<......>>>>>>>.>>................>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<..<<<<<<<<..<<.......>>>..>>>>>>>...>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>. ...((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((......(...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)..)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....))))))))))....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))..................)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((.(.(.......))..)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......(((((...(..((...........))..).......(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((......))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((.(((((.((.(.........(...(...((...(((.(((......))).))).))..............)..)).)).))))).)))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...)))). Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet and cognate tRNAThr in the A-site; 23S ribosomal RNA 6gsj 16 122 2.96 RF00001 URS00005AB4A7_300852 29931292 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga ..<<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> ..(((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).))))))))))) Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet and cognate tRNAThr in the A-site; 5S ribosomal RNA 6gsj 1G 1490 2.96 RF00177,RF01959,RF01960 URS000080E226_300852 29931292 0003735 0005840 300852 uuguuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugg ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<<..>>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<...<<...<<<.....>>>.>>....>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.. ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((((((((.().))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((.((...)).)))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(.((((((...((((((....))))))....)))))).)).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((....(..(((.....)))).....))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((..((.(....).))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((..........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}. Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet and cognate tRNAThr in the A-site; 16S ribosomal RNA 6gsj 1L 74 2.96 RF00005 URS00004A988A_83333 29931292 0030533 0006412 83333 gcugauauagcucagnggagagcgcacccuuggunagggugaggucggcagnucgacucugccuaucagcacca <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>......<<<<.......>>>>.>>>>>>>.... .........(((........))).(((((.......)))))......((((.......))))............ Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet and cognate tRNAThr in the A-site; tRNAThr 6gsj 2L 77 2.96 RF00005 URS000041AF00_83333 29931292 0030533 0006412 83333 cgcggggnggagcagccugguagcucgucgggnucauaacccgaagnucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet and cognate tRNAThr in the A-site; tRNAfMet 6gsj 3L 72 2.96 RF00005 URS00005B2D1B_83333 29931292 0030533 0006412 83333 gcugauauagcucaguagagcgcacccuugguaagggugaggucggcagnucgaaucugccuaucagcacca <<<<<<<..<<<<....>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((....((.(.[..).)).(((((.......)))))....](((((.......)))))..))))).... Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet and cognate tRNAThr in the A-site; tRNAThr 6gsj 4L 14 2.96 URS0000D77948_83333 29931292 83333 aaaaaugaccaaaa .............. .............. Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet and cognate tRNAThr in the A-site; RNA (27-MER) 6gsj 14 2811 2.96 RF02540,RF02541,RF00002 URS0000868533_300852 29931292 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaacggcgaaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuaggaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcggacauggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccuguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggu .........<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<..>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>..............>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...........>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<..............>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<.<<<<<<<.........<<.....<<<......<<<<<<<<<..>>>>>>>>>...>>>..............>>..>>>>>>>.>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<.......>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>..... .........((((((((((.....(((..((((((((((((......((((((.[[..[[[)))...].((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((......)))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((((((((..).))))))))....(.(((((((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))..............)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((...........)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((((..................))))))).))..........]]].)....))))))))))...)))))))((((((.........))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((.(((((.(((.(.......((.....((.......((..((((....))))..))....))..............))).))).))))).))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(..................(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...). Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet and cognate tRNAThr in the A-site; 23S ribosomal RNA 6gsj 1J 122 2.96 RF00001 URS00005AB4A7_300852 29931292 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga ..<<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> ...((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).)))))))))). Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet and cognate tRNAThr in the A-site; 5S ribosomal RNA 6gsk 13 1500 3.36 RF00177,RF01959,RF01960 URS0000868551_300852 29931292 0003735 0005840 300852 uuguuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgcguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggacac ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<....>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<....<<<......>>>.......>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>.....<......>....>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<...<<<<....>>>>...>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ........(((...[.[[[...))).((((.(((((..(((((((((....(((.(((..(((..((.(((((....))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(......((.....)).......)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..((((((((....((((((((....((((((....((........)).......))))))....).......((....)).)))))))...)))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((.(..((((((((((......((........))..........(((((((..(...((((.(((..(((((((....))))))).................))).))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.((((((...(((..(((.....))))))....)))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...((((((......(((..((..((((....))))..))....)))......))))))......(....(((((((........)))))))....)..)..).))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet and near-cognate tRNAThr in the A-site; 16S ribosomal RNA 6gsk 1K 74 3.36 RF00005 URS00004A988A_83333 29931292 0030533 0006412 83333 gcugauauagcucagnggagagcgcacccuuggunagggugaggucggcagnucgacucugccuaucagcacca <<<..<...<<<<......>>>>.<<<<<<.....>>>>>>......<<<<.......>>>>..>..>>>.... ...(....................(((((.......))))).......(((.......))).....)....... Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet and near-cognate tRNAThr in the A-site; tRNAThr 6gsk 2K 77 3.36 RF00005 URS000041AF00_562 29931292 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet and near-cognate tRNAThr in the A-site; tRNAfMet 6gsk 3K 72 3.36 RF00005 URS00005B2D1B_562 29931292 0030533 0006412 562 gcugauauagcucaguagagcgcacccuugguaagggugaggucggcaguucgaaucugccuaucagcacca <<<<.....<<<<....>>>>.<<<<<<.....>>>>>>.......<<<.......>>>.....>>>>.... (((..(...(.((....)).).(((((.......)))))........((.......))....)..))).... Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet and near-cognate tRNAThr in the A-site; tRNAThr 6gsk 4K 18 3.36 29931292 83333 gguaaaaaugaucaaaaa .................. .................. Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet and near-cognate tRNAThr in the A-site; mRNA 6gsk 1H 2811 3.36 RF02540,RF02541,RF00002 URS0000868533_300852 29931292 0003735 0005840 300852 uaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaacgggggccgaaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuaggccucaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggaaaugccucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccuaacccccgccuccggguggggggggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccuccguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccg ...<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.....>>>>>>.>>....<<<<<.....<......>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....<<.....>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<............>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<...........>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>>....<<<......>>>......>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<........<..<<<<<<<<....>>>>>>>>.>.................>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<<<<<<<<<..<<.......>>>..>>>>>>>..>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>. 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Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet and near-cognate tRNAThr in the A-site; 23S ribosomal RNA 6gsk 16 122 3.36 RF00001 URS00005AB4A7_300852 29931292 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga ..<<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> ..(((((((((((....((((((((....(.(((((...(.....)...))))..).)...)))))).))(((.......((.(((((....))))).)).......))).))))))))))) Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet and near-cognate tRNAThr in the A-site; 5S ribosomal RNA 6gsk 1G 1490 3.36 RF00177,RF01959,RF01960 URS0000868551_300852 29931292 0003735 0005840 300852 uuguuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugg ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<<..>>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<.......<........>...........<<<<<<<......<<<<<<<....<.<<<<....>>>>.>.....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<...<<...<<<.....>>>.>>....>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>.. ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((((((((.().))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((.(..((((((((((......((........))..........(((((((..(...(.((((((...(((.((....)).)))....)))))).)).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.((((.((...((..(((.....)))))....)).)))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..).))).....(((((((..........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}. Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet and near-cognate tRNAThr in the A-site; 16S ribosomal RNA 6gsk 1L 74 3.36 RF00005 URS00004A988A_83333 29931292 0030533 0006412 83333 gcugauauagcucagnggagagcgcacccuuggunagggugaggucggcagnucgacucugccuaucagcacca <<<<<<...<<<<......>>>>.<<<<<<.....>>>>>>......<<<<.......>>>>..>>>>>>.... ...(.....((..........)).(((((.......)))))......((.(.......).))....)....... Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet and near-cognate tRNAThr in the A-site; tRNAThr 6gsk 2L 77 3.36 RF00005 URS000041AF00_562 29931292 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).((((.........)))).....(((((..]....)))))))))))..... Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet and near-cognate tRNAThr in the A-site; tRNAfMet 6gsk 3L 72 3.36 RF00005 URS00005B2D1B_562 29931292 0030533 0006412 562 gcugauauagcucaguagagcgcacccuugguaagggugaggucggcaguucgaaucugccuaucagcacca <<<<<<<..<<<<....>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... ((((((...(.((....)).).(((((.......))))).....((.((.......)).)).)))))).... Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet and near-cognate tRNAThr in the A-site; tRNAThr 6gsk 4L 14 3.36 29931292 83333 aaaaaugaucaaaa .............. .............. Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet and near-cognate tRNAThr in the A-site; mRNA 6gsk 14 2811 3.36 RF02540,RF02541,RF00002 URS0000868533_300852 29931292 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaacggcgaaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuaggaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcggacauggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccuguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggu .........<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<..>>>>>>.>>....<<<<<.....<......>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>..............>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<....<<...<<<<<<<<...........>>>>>>>>..>>.....>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<..............>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<.<<<<<<<.........<<......<<......<<<<<<<<....>>>>>>>>...>>...............>>..>>>>>>>.>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<..<<<<<<<...<<.......>>...>>>>>>>...>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<.............>>>>....>>>.>>>>.......>>>>>>>...<<.......>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>..... .........((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((....))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...(((((((((..).))))))))....{.(((((((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).))))....(((((((((.[.....)))))))))....}.(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..((....(((.....)))....))...((....))..((((.....))))..............)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((...........)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((.......(.....((..((((((((................)))))))).))..........]]].)......))))))))...)))))))((((((.........))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((((.......)))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((.(((((.(((.........(...............((..((((....))))..)).....................)..))).))))).))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.((((...........))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(..................(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...). Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet and near-cognate tRNAThr in the A-site; 23S ribosomal RNA 6gsk 1J 122 3.36 RF00001 URS00005AB4A7_300852 29931292 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga ..<<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> ...((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).)))))))))). Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet and near-cognate tRNAThr in the A-site; 5S ribosomal RNA 6gsl 13 1512 3.16 RF00177,RF01959,RF01960 URS000080E226_300852 29931292 0003735 0005840 300852 uuguuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggacacc ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<<<...>>>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<.........<<<.....>>>...........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>....<<......>>...>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>....... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(.(((((((((...))))))))).).)))))......(((......((((((((..((...(((((((.(((((....((((.(....).)))).....)))))....((((.(((((....))))).))))...(((.....))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(.(((....)))..))))).)).))))))..((((......((((....)))).....))))....(((((...(.......(.....)........)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((((..(((((((....))))))).................))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((.......(((.....)))......))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...((((((......(((..(((.((((....))))).))....)))......))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}...... Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet and cognate tRNAArg in the A-site; 16S ribosomal RNA 6gsl 1K 72 3.16 RF00005 URS00021ED91C_83333 29931292 0030533 83333 gcauccgnagcucagggagaguacucggnuicgnaccgagcgncggaggnucgaauccucccggaugcacca <<<<<<<..<<<<.....>>>>.<<<<<.......>>>>>....<<<<<.......>>>>>>>>>>>>.... ((.((((...(((...[.)))..(((((.......)))))....(((((..]....))))))))).)).... Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet and cognate tRNAArg in the A-site; tRNAArg 6gsl 2K 77 3.16 RF00005 URS000057545F_83333 29931292 0030533 0006412 83333 cgcggggnggagcagcccgguagcucgucgggnucauaacccgaagnucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet and cognate tRNAArg in the A-site; tRNAfMet 6gsl 3K 73 3.16 RF00005 URS000077ECB7_83333 29931292 0030533 0006412 83333 gcaucuguagcucagcggagaguacucggcuacgaaccgagcggucggagguucgaaccucccggaugcacca <<<<<<...<<<<......>>>>.<<<<<.......>>>>>.....<<<<<......>>>>>.>>>>>>.... (((...(....((......))...((((.........)))).....(((((......))))))...))).... Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet and cognate tRNAArg in the A-site; tRNAArg 6gsl 4K 21 3.16 29931292 83333 ggagguaaaaaugcgaaaaaa ..................... ..................... Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet and cognate tRNAArg in the A-site; mRNA 6gsl 1H 2895 3.16 RF02540,RF02541,RF00002 URS0000868533_300852 29931292 0003735 0005840 300852 aagaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaacgggggccgaaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggauguuggcuuagaagcagccaucauuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucuu .<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.....>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....<<.....>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<.<.<<<<<<......>>>>.>>.>.>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<....<<<<.......>>>>.....>........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<.<<<<<<<<<...........<<...<..<<......<<<<<<<<....>>>>>>>>...>>.............>..>>..>>>>>>>>>.>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<..<<<<<<<...<<.......>>...>>>>>>>...>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<.........>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>. .(((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((......(...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)..)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....((.....))....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((.(.((((((......)))).)))..)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[.....((((((.....(.....((..((((((((((.......(((((...(..(((.........)))..).......(...((......)).).)))))...)))))))))).))..........]]].)....)))))).)))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((......))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((.(((.(((((.((.(.........((.((...(........((((.(......).)))).....).............)).))).)).))))).))).)))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(..................(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))). Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet and cognate tRNAArg in the A-site; 23S ribosomal RNA 6gsl 16 122 3.16 RF00001 URS00005AB4A7_300852 29931292 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga ..<<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> ..(((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).))))))))))) Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet and cognate tRNAArg in the A-site; 5S ribosomal RNA 6gsl 1G 1509 3.16 RF00177,RF01959,RF01960 URS000080E226_300852 29931292 0003735 0005840 300852 uuguuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucac ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<<..>>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>....<<<<.<<<<<....>>>>>.>>>>...<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>....<<......>>...>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<...<<...<<<.....>>>>.>....>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>....... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((((((((.().))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((.......(((....)))......))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((.(..((((((((((......((........))..........(((((((..(.....((((((....(((((....)))))......((......))...))))))..).((.(((....(((((.(....(((((((((....)))...(((......)))...)))))).....((((.((((((........(((.....))).......)))))).....(((((....)))))........)))).....).).)))...)..)))))....)))))))...)).)))))))).(...(((((((.....(((..((..(((......)))..))....))).....)))))))......(....(((((((........)))))))....)..)..).))).....(((((((..........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}...... Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet and cognate tRNAArg in the A-site; 16S ribosomal RNA 6gsl 1L 74 3.16 RF00005 URS00021ED91C_83333 29931292 0030533 83333 gcauccgnagcucagcuggagaguacucggnuicgnaccgagcgncggaggnucgaauccucccggaugcacca <<<<<<<..<<<<.......>>>>.<<<<<.......>>>>>....<<<<<.......>>>>>>>>>>>>.... ((.((((..((((.....[.)))).(((((.......)))))....(((((..]....))))))))).)).... Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet and cognate tRNAArg in the A-site; tRNAArg 6gsl 2L 77 3.16 RF00005 URS000057545F_83333 29931292 0030533 0006412 83333 cgcggggnggagcagcccgguagcucgucgggnucauaacccgaagnucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet and cognate tRNAArg in the A-site; tRNAfMet 6gsl 3L 74 3.16 RF00005 URS000077ECB7_83333 29931292 0030533 0006412 83333 gcaucuguagcucagcuggagaguacucggcuacgaaccgagcggucggagguucgaaccucccggaugcacca <<<<<<...<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<......>>>>>.>>>>>>.... ((((..(...(((.......)))..((((.........)))).....(((((......))))))..)))).... Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet and cognate tRNAArg in the A-site; tRNAArg 6gsl 4L 17 3.16 29931292 83333 ggagguaaaaugcgaaa ................. ................. Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet and cognate tRNAArg in the A-site; mRNA 6gsl 14 2895 3.16 RF02540,RF02541,RF00002 URS0000868533_300852 29931292 0003735 0005840 300852 ggucaagaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaacggcgaaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggauguuggcuuagaagcagccaucauuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcuaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucuugacc ..............<<<<<<<<<<<.....[[..[[<<<<<<[[<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<....>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...(((....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>.]]...............<<....>>....]].........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>..............>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<.....<<<<......>>>>......>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..((((...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.........<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<..........<<.....<<<......<<<<<<<<<..>>>>>>>>>...>>>...............>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<.(((..>>>>..)))>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))))>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<.............>>>>....>>>.>>>>.......>>>>>>>..<<<.......>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>............ ..............((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((......)))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...((((((((.....))))))))....{.(((((((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).))))....(((((((((.[.....)))))))))....}.(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))..............)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((.(.((((((......)))).)))..)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......(((((.(((..(((.........)))..))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))(((((((.......)))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(....(((....)))......))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((..(((((.(((..........(((....((.......(((.((((....)))).)))....))..............)))..))).)))))..)))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(..................(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)........ Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet and cognate tRNAArg in the A-site; 23S ribosomal RNA 6gsl 1J 122 3.16 RF00001 URS00005AB4A7_300852 29931292 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga ...<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>>. .....((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).))))))))... Structure of T. thermophilus 70S ribosome complex with mRNA, tRNAfMet and cognate tRNAArg in the A-site; 5S ribosomal RNA 6gsm 1 74 5.15 RF00005 URS0000E60B6B_559292 34648019,26212456 0030533 0006412 559292 agcgccgunncgcagnggaagcgcncagggcucaunacccugaunnnnucggaucgnaaccgngcggcgcuacc <<<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.......<<<.......>>>..>>>>>>>... ((((((([.((((.]..[..)))).(((((.......))))).....(.(((..]....))).))))))))... Structure of a partial yeast 48S preinitiation complex in open conformation.; Met-tRNAi 6gsm 2 1798 5.15 RF01960,RF01959,RF00177 URS0000433DD8_284590 34648019,26212456 0003735 0005840 284590 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacauggauaucugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacuccuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaacuggagggcaagucuggugccagcagccgcgguaauuccagcuccaguagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggucugguuguccgguccgacuuuaugucgcgcacugguuuucaaccggaucuuuccuucuggcuaaccuguacuccuugugggugcaggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcgaaagcucgaauauauuagcauggaauaauggaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuucuuaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaggguugcuggcacuugccgguugacucuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgaguacaaccuuggccgagaggucuggguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggauuugcuuagagaagggggcaacuccaucucagagcgaagaaucuggucaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[...<....<<....<<..........>>...>>.>.......{{........[[[......{{....[[[{...............<<.....<<..<.......>..>>......>>........<<<<<............>>>>>{..[[.((((......<<<<<<<<.<......>...............))))]].....}...<<<<..<<<.....>>>.>>>>..}.]]]...}}....]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<......>.>...]]]]]].........<<<....<<<.....>>>..>>>................<..<<<<<.<.......>..>>>>>...>.......<<..<...........>.>.>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.{{.....<<<<<<<<<<.<<<<<.<<<.......>>>...>>>>>....>>>>>>>>>>.....<<<<<<......<.................>......>>>>>>...<<<<<.<<......<<<...<.......>..<<<....>>>....>>.>....>>.>>..>>>.........[[[..(((((((.....>>>>>>>>..))))))).]]].....}}....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<........>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<.<.......>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<.<......>.>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<..<<........>>..>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<......>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<....<<<<<.<<<<....>>>>.>.>>>>....>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<<..<<<....>>>..>>>....>>.......>>>>>>>......<....<<<<<<..........>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<......<<<<<<.<<..................>>...>>>>>>......>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))((((..(((((...(.(...((.....(((.(((..((....((.....(..........)....)){))......(((.......(((..((...(....(((............{...((.....((.(((.....))).))......)).........((((..((....))..)))).(.(((..(((......[[[[[[....(....).......(......).))).)).)...).(}((((...((.....))..)))))..).))...)).)..))).(((.A..(((....((((((((.......)))))))))))......)))...(((.(((......)))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....((..(((.(..((....))..).)))...))......(((.(...........)).)).........(((.([[....(.((((.....((..]])).......)))))).)))..))))).))))..{......(.({......(.((...(((.((.....((((((((((.(((((.(((.......)))...)))))....)))))))))).....((((((...............................))))))...(((((.(.......(((..((.......)).(((....)).)...)).).....).))..))).........(((..(.(..(((......]]]]]].)))...)).))).....))....((..((.((...((((..((..(.(.((.....((........))........)).).)..)).......((....))...))))..)).))...))...)))...)).)....((((((........((.(.........).)).....))))))......<...(((.((.(((...(((((((.((.(.......))))))))))...)))...((..}.))...))...}.))).).)..((....a.((((....))))....))....]]]..]((((.(((((((..((..(((.(..(((.((((((......((........))..........(((((.(....((((.........((...(........)..).).......))))....(.(((...(.((((((....(((.(.(((....)))..(.((......)))....).)))....(((((.((..((((.....(((((.(((....))).)).))).....)))).))..(.(((.(........))))....)..)))))....))).))).....).))))......).)))))...)).)))).))).(...(((((((......((.....(.(..(((....)).).).)....)).......)))))))......(....((((((..........))))))....)..)..).))).....(.((((((.......)))))).)......))...)))))))))).)...(.(..((.(..((((.((..(.((((((((.(((..((((..(...(((((............................)))))...)..))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>........ Structure of a partial yeast 48S preinitiation complex in open conformation.; 18S ribosomal RNA 6gsn 2 1798 5.75 RF01960,RF01959,RF00177 URS0000433DD8_284590 34648019,26212456 0003735 0005840 284590 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacauggauaucugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacuccuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaacuggagggcaagucuggugccagcagccgcgguaauuccagcuccaguagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggucugguuguccgguccgacuuuaugucgcgcacugguuuucaaccggaucuuuccuucuggcuaaccuguacuccuugugggugcaggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcgaaagcucgaauauauuagcauggaauaauggaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuucuuaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaggguugcuggcacuugccgguugacucuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgaguacaaccuuggccgagaggucuggguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggauuugcuuagagaagggggcaacuccaucucagagcgaagaaucuggucaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<...[[[[>>>>>[[[..((((((................[[[.[[[..<<....<<....<<..........>>..>.>.>>......{{........[[[..{{..{.....[[[{...............<<.....<<.<<.......>>.>>......>>........<<<<<..<<....>>..>>>>>{..[[.((((......<<<<<<<<<<<....>>>..............))))]].....}...<<<<..<<<.....>>>.>>>>..}.]]]....}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>...<<....>>.....]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<<<<<<..........>>>>>>>.>>.>.....<...<...........>...>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..)))))).]]].........[[[{{.......{{...[[[.[[....<<<<<<<<<<<.<<<<<.<<<.......>>>...>>>>>....>>>>>>>>>>>....<<<<<<......<<<<<<.......>>>>>>......>>>>>>...<<<<<.<<.......<<...<.......>..<<<....>.>>...>>......>>.>>..>>>.........[[...(((((((.....>>>>>>>>..)))))))..]].....]]....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<......>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<......<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<......>>...<<<......>>>...>>.>>>....<<<<..<<..<<<<..<<<<<<<<<<<<....>>>>>>.>>>>>>..>>>>.>>....<<<<<<.....>>>>>>........>>>>....>>>.>>>.....>>>>>>>.......>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<.<..<<<....>>>...>>....>>.......>>>>>>>......<....<<<<<<..........>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<..<...<<<<<<..........................>>>>>>...>..>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>......<<<<<<<<<..>>>>>>>>>.......... ...((((..[.[[[..))))((((..(..((...(.(...((.....(((.(((..((....((.....(..........)...).){))......(((.......(((..((...(....(((............{...((.....((.(((.....))).))......))........(((((..((....))..)))))(.(((.((((......[[[[[[[.(((....))).....(......).)))))).)...).(}((((..((((..).))).)))))...)))...)).)..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).))...((....)).....)))))).).....(.(((...((((.}...))).))))).)....).).....((..(((.(..((....))..).)))...))......(.(.(...........))..).........(((..[[....(.((((.....((..]])).......)))))..)))..))..).))))..{......((({......(.((...(((.((....(((((((((((.(((((.(((.......)))...)))))....)))))))))))....((((((.........((.........)).........))))))...((.((.((.......(...((.......)).(.(....)..)....)......)).))...)).........(....(..(.(((.....]]]]]]].))).)..)...).....))....((..((..(...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)..))...))...)))...)).)....((((...........(.(.........).)........))))......<...(((.((.(((...(((((((.((.(.......))))))))))...)))...((...}))...))...}.))).)))..((......((((....))))....))....]]].](((((.(((((((..((.((((((..((((.(((((......((........))........(.(((((.(....(((((........((.((..........))).)......)))))....(.(((...(.((((((....(((.(.(((....)))..(.((......)))....).)))....(((((.((..((((..(((((..(((((....)))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))......).))))))..)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))))....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..((((..(...(((((............................)))))...)..))))..))).)))))))))..)).))))...).))...)..)..(.(((((((....)))))))).>........ Structure of a partial yeast 48S preinitiation complex in closed conformation; 18S rRNA (1798-MER) 6gsn 3 14 5.75 34648019,26212456 559292 aucucucucuaugc .............. .............. Structure of a partial yeast 48S preinitiation complex in closed conformation; mRNA 6gsn 1 75 5.75 RF00005 URS000080E1DE_559292 34648019,26212456 0030533 0006412 559292 agcgccguggcgcaguggaagcgcgcaggucucauaaaccugauguccucggaucgaaaccgagcggcgcuacca <<<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.......)))).(((((.......))))).....(((((.......)))))))))))).... Structure of a partial yeast 48S preinitiation complex in closed conformation; tRNAi (75-MER) 6gwt A 2896 3.8 RF02540,RF02541 URS0000A76322_562 30076302 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugucgaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaaggggguacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccgggagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>...................<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<<<<..>>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>...>.>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<..>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<.....<<.........>>.....>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<..<......>..>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<....<<..>>.....>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<<.<<....>>..>>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((.(((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).)..........(....)....(((((.....((.]...))....)))))...((((.((((......((((((((((.((.(((...(((((......)))))[[(...).(((.....]])))...)))...)).))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((.(((....))).))..)))).[.(.(........).).((((((....((((.((((((.(..(((...((.....))...)))...((....))..((((.....)))).....).)))))).))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.((.......))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((.((..))..))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((....(.....{..(.((.(.......................).....(..(((......)))).)).)....)....))))).))...........]]].)...))))))))))...)))))))((((...(......)...))))....))))))(.(((((...(((......((.(((((....))))).))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..(((.(....).)))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((.(((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).).))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((((.((...((((............(.((...(........((((((......)))))).....).............)).)...))))...)).))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..))))..((....))..))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)....))..)))))))))))[...(((((((...((((..(.(((((.....(....)....))))).).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....(.((.....}.......)).)....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).)))))).)). Cryo-EM structure of an E. coli 70S ribosome in complex with RF3-GDPCP, RF1(GAQ) and Pint-tRNA (State I); 23S ribosomal RNA 6gwt B 120 3.8 RF00001 URS00008116C5_562 30076302 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<<.....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....((((((....(.....)....)))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Cryo-EM structure of an E. coli 70S ribosome in complex with RF3-GDPCP, RF1(GAQ) and Pint-tRNA (State I); 5S ribosomal RNA 6gwt a 1539 3.8 RF00177,RF01959,RF01960 URS000080DDC0_562 30076302 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<.<<....>>.>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.<...>.>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<.<.<<<......>>>.....>>>>>>>>>...........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<<..<<<.....>>>>>.....>>>>>>.....<<<<<.....>>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((............))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....(((((......)))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((..((....((((((((.......)))))))).....)..).)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....))))))).............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((.....((..(((.....)))))......)))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Cryo-EM structure of an E. coli 70S ribosome in complex with RF3-GDPCP, RF1(GAQ) and Pint-tRNA (State I); 16S ribosomal RNA 6gwt x 77 3.8 RF00005 URS000041AF00_562 30076302 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Cryo-EM structure of an E. coli 70S ribosome in complex with RF3-GDPCP, RF1(GAQ) and Pint-tRNA (State I); fMet-tRNA 6gxm A 2896 3.8 RF02540,RF02541 URS0000A76322_562 30076302 0003735 0005840 562 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<<<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>...................<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<<<<..>>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>...>.>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<..>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<.....<<.........>>.....>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<..<......>..>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<....<<..>>.....>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<<.<<....>>..>>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((.(((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((.(((...(((]]]..].))).......))).))...)))....(((....)))(((((((....))))))).((((((((...........)))))))).))...((((((.....(...[..)......))))).)..........(....)....(((((.....((.]...))....)))))...((((.((((......((((((((((.((.(((...(((((......)))))[[......(((.....]])))...)))...)).))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((.(((....))).))..)))).[.(.(........).).((((((....((((.((((((.(..(((...((.....))...)))...((....))..((((.....)))).....).)))))).))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.((.......))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(..((..))...)...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((....(.....{..(.((.(.......................)........(((......)))..)).)....)....))))).))...........]]].)...))))))))))...)))))))((((...(......)...))))....))))))(.(((((...(((......((.(((((....))))).))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..(((.(....).)))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((.(((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).).))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((...((.(............(..(...(........((((((......)))))).....).............)..)...).))...)))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..))))..((....))..))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((.(((..(((((((((......))))))..))).(((((.....))))).....))).)..)...))..).....(..((((....))).)..)....))..)))))))))))[...(((((((...((((..(.(((((.....(....)....))))).).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....(.((.....}.......)).)....))).))))..]....)))))))(.((.((.....).)))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).)))))).)). Cryo-EM structure of an E. coli 70S ribosome in complex with RF3-GDPCP, RF1(GAQ) and Pint-tRNA (State II); 23S ribosomal RNA 6gxm B 120 3.8 RF00001 URS00008116C5_562 30076302 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<<.....<<<<<<<.....<<<<<<...............>>>..>>>....>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....((((((....(.....)....)))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Cryo-EM structure of an E. coli 70S ribosome in complex with RF3-GDPCP, RF1(GAQ) and Pint-tRNA (State II); 5S ribosomal RNA 6gxm a 1539 3.8 RF00177,RF01959,RF01960 URS000080DDC0_562 30076302 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<.<<....>>.>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>..<<.<<<<<......<.<<<<<<<<.<...>.>>>>>>>>.>........>>>>>....>>.<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<.<.<<<......>>>.....>>>>>>>>>...........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<<..<<<.....>>>>>.....>>>>>>.....<<<<<.....>>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((............))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....(((((......)))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((..((....((((((((.......)))))))).....)..).)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....))))))).............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((.....((..(((.....)))))......)))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Cryo-EM structure of an E. coli 70S ribosome in complex with RF3-GDPCP, RF1(GAQ) and Pint-tRNA (State II); 16S ribosomal RNA 6gxm x 77 3.8 RF00005 URS000041AF00_562 30076302 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Cryo-EM structure of an E. coli 70S ribosome in complex with RF3-GDPCP, RF1(GAQ) and Pint-tRNA (State II); fMet-tRNA 6gxn A 2895 3.9 RF02540,RF02541 URS0000A76322_562 30076302 0003735 0005840 562 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(.(((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).)..........(....)....(((((.....((.]...))....)))))...((((.((((......((((((((((.((.(((...(((((......)))))[[......(((.....]])))...)))...)).))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((.(((....))).))..)))).[.(.(........).).((((((....(((((((((((.(..(((...((.....))...)))...((....))..((((.....)))).....).)))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.((.......))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((.(....)..))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((....(.....{..((((.(.......................).....(..(((......)))).))))....)....))))).))...........]]].)...))))))))))...)))))))((((...(......)...))))....))))))(.(((((...(((......((.(((((....))))).))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..(((.(....).)))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((.(((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).).))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((...((.(............(..(...(........((((((......)))))).....).............)..)...).))...)))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((.(((..(((((((((......))))))..))).(((((.....))))).....))).)..)...))..).....(..((((....))).)..)....))..)))))))))))[...(((((((...((((..(.(((((.....(....)....))))).).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....(.((.....}.......)).)....))).))))..]....)))))))(.((.((.....).)))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))..). Cryo-EM structure of an E. coli 70S ribosome in complex with RF3-GDPCP, RF1(GAQ) and Pint-tRNA (State III); 23S ribosomal RNA 6gxn B 120 3.9 RF00001 URS00008116C5_562 30076302 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<<.....<<<<<<<.....<<<<<<...............>>>..>>>....>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....((((((....(.....)....)))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Cryo-EM structure of an E. coli 70S ribosome in complex with RF3-GDPCP, RF1(GAQ) and Pint-tRNA (State III); 5S ribosomal RNA 6gxn a 1539 3.9 RF00177,RF01959,RF01960 URS000080DDC0_562 30076302 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<.<<....>>.>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>..<<.<<<<<......<.<<<<<<<<.<...>.>>>>>>>>.>........>>>>>....>>.<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<.<.<<<......>>>.....>>>>>>>>>...........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<<..<<<.....>>>>>.....>>>>>>.....<<<<<.....>>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((............))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....(((((......)))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((..((....((((((((.......)))))))).....)..).)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....))))))).............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((.....((..(((.....)))))......)))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Cryo-EM structure of an E. coli 70S ribosome in complex with RF3-GDPCP, RF1(GAQ) and Pint-tRNA (State III); 16S ribosomal RNA 6gxn x 77 3.9 RF00005 URS000041AF00_562 30076302 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Cryo-EM structure of an E. coli 70S ribosome in complex with RF3-GDPCP, RF1(GAQ) and Pint-tRNA (State III); fMet-tRNA 6gxo A 2900 3.9 RF02540,RF02541 URS0000A76322_562 30076302 0003735 0005840 562 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<<<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<<<<..>>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>...>.>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<.<..>.>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<.....<<.........>>.....>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<............>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<....<<..>>.....>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<<.<<....>>..>>>>>>........>>>>>>>>..>>>>>.<<<<<.......>>>>>.........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. .(((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).)..........(....)....(((((.....((.]...))....)))))...((((.((((......((((((((((.((.(((...(((((......)))))[[(...).(((.....]])))...)))...)).))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((.(((....))).))..)))).[.(.(........).).((((((....((((.((((((.(..(((...((.....))...)))...((....))..((((.....)))).....).)))))).))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.((.......))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(..((.(..).))...)...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{..(.((.(.......................)........(((......)))..)).)....)))..))))).))...........]]].)...))))))))))...)))))))((((...(......)...))))....))))))(.(((((...(((......((.(((((....))))).))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..(((.(....).)))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((...((.(.(..........(.((...(........((((((......)))))).....).............)).).).).))...)))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..))))..((....))..))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)....))..)))))))))))[...(((((((...((((..(.(((((.....(....)....))))).).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....(.((.....}.......)).)....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))).). Cryo-EM structure of a rotated E. coli 70S ribosome in complex with RF3-GDPCP, RF1(GAQ) and P/E-tRNA (State IV); 23S ribosomal RNA 6gxo B 120 3.9 RF00001 URS00008116C5_562 30076302 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....((((((....(.....)....)))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Cryo-EM structure of a rotated E. coli 70S ribosome in complex with RF3-GDPCP, RF1(GAQ) and P/E-tRNA (State IV); 5S ribosomal RNA 6gxo a 1539 3.9 RF00177,RF01959,RF01960 URS000080DDC0_562 30076302 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<<....>>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<<..<<<.....>>>>>.....>>>>>>.....<<<<<.....>>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<.<<<<........>>>>.>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((((..........)))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(.(......(.((....)).)....).)...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))....(....)...))))).))).((.(.(...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..((.......))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).).)))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....((..(((........)))..))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(.(..((((((((((((....((((((.(((...((....))..)))))))))...))))))))))))..).).))))..).))...)..)..(((((((((....)))))))))}........... Cryo-EM structure of a rotated E. coli 70S ribosome in complex with RF3-GDPCP, RF1(GAQ) and P/E-tRNA (State IV); 16S ribosomal RNA 6gxo x 77 3.9 RF00005 URS00001BBAFC_562 30076302 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaagaucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>......<<<.........>>>.>>>>>>..... .((((((..((((......[..)))).(((((.......))))).......((...].....))..))))))..... Cryo-EM structure of a rotated E. coli 70S ribosome in complex with RF3-GDPCP, RF1(GAQ) and P/E-tRNA (State IV); fMet-tRNA 6gxp A 2896 4.4 RF02540,RF02541 URS0000A76322_562 30076302 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugucgaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaaggggguacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccgggagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>...................<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<<<<..>>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>...>.>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<..>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<.....<<.........>>.....>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<..<......>..>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<....<<..>>.....>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<<.<<....>>..>>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((.(((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((.(((...(((]]]..].))).......))).))...)))....(((....)))(((((((....))))))).((((((((...........)))))))).))...((((((.....(...[..)......))))).)..........(....)....(((((.....((.]...))....)))))...((((.((((......((((((((((.((.(((...(((((......)))))[[(...).(((.....]])))...)))...)).))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((.(((....))).))..)))).[.(.(........).).((((((....((((.((((((.(..(((...((.....))...)))...((....))..((((.....)))).....).)))))).))))..((.(...((((((.....((((((((((.((((....(((((......)))))....)[)))...(((.(((((........))))))))..).))))))))).(.((.......))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((.((..))..))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{..(.((.(.......................)........(((......)))..)).)....)))..))))).))...........]]].)...))))))))))...)))))))((((...(......)...))))....))))))(.(((((...(((......((.(((((....))))).))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..(((.(....).)))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((.(((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).).))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((((.((...((((............(.((...(........((((((......)))))).....).............)).)...))))...)).))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..))))..((....))..))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((.(((..(((((((((......))))))..))).(((((.....))))).....))).)..)...))..).....(..((((....))).)..)....))..)))))))))))[...(((((((...((((..(.(((((.....(....)....))))).).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....(.((.....}.......)).)....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).)))))).)). Cryo-EM structure of a rotated E. coli 70S ribosome in complex with RF3-GDPCP(RF3-only); 23S ribosomal RNA 6gxp B 120 4.4 RF00001 URS00008116C5_562 30076302 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<<.....<<<<<<<.....<<<<<<...............>>>..>>>....>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....((((((....(.....)....)))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Cryo-EM structure of a rotated E. coli 70S ribosome in complex with RF3-GDPCP(RF3-only); 5S ribosomal RNA 6gxp a 1539 4.4 RF00177,RF01959,RF01960 URS000080DDC0_562 30076302 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<.....(((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<.<<....>>.>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.<...>.>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<.....<<<<<<....<<<......>>>.......>>>>>>............<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))....<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<<..<<<.....>>>>>.....>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>.....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((.....[...)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((............))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....(((((......)))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((..((....((((((((.......)))))))).....)..).)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((.(....((((((....((........)).......))))))....).......((....))..))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(.(......((((....))))....).)....]....((((..((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))....(....)...))))).))).((.(.(...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((.....((..((.......))))......)))))..(..(((((.....))))).....)..)))).....).).)))...)).).)))....)))))))...)).)))))))).(...((((((......(((..((...(((....)))...))....)))......))))))......(....(((.(((........))).)))....)..)..))))).....(((((((.........)))))))......))...)))))).))).)...(.(..((.(.((((.(((..((((((((((((....(((.((.((((..((....)).)))))).)))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Cryo-EM structure of a rotated E. coli 70S ribosome in complex with RF3-GDPCP(RF3-only); 16S ribosomal RNA 6gz3 A2 3612 3.6 RF02540,RF02543 URS0000E60BB6_9986 30517857 0003735 0005840 9986 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgcgcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcggcccggcggaucuuucccgcccccggggucggcgggggaccgucccccggaccggcgaccggccgccgccgggcgcauuuccaggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucggggcccccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcgcucuccccccugggggggccgggccaccccucccacggcgcgaccgcucucccagggggcggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccggggggccacgcgcgcgucccgggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgaggggcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcccacgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggccuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcuggcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacaugagagguguagaauaagugggaggcccgggccgccggugaaauaccacuacucugaucguuuuuucacugacccggugaggcgggggggcgagcccgaggggcucucgcuucuggcgccaagcgcccgcccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucgccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccgguccgggguccggugcggagugcccuucguccugggaaacggggcgcggccggaaaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuuguc .........................<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..[[[..<...<.....<<<<.<.........>>>>>.......>..>...<.<<..<<.<....<<<<....<<...<<.<<.......<.<........>..>.................................>>>>.>>.>>.>>...>>>..>>.>.......<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<.<.....<..<<.<..<<<.....<<<..<..<.....<...<<.<<<<.<....<<<<<.<<<..<<<<<<<<<.>>>..>>>>>>>>>>>>>>>>>.>>>>......>...>..>..>.>>....>>>..>.>>..>..<<<<<<<<.<<<<<<<<<<.<<<........<<.<<<.<.<<...<..<<<<<<<<.>>>>>>>>..>.....>>>.>>>>>...........>>>...>>>>>>>>>>....................<<<.....<<<<<..>>>>.>..<.<<<..<<<.<<...<.<<<<<<<<<<...<<...>>.<<<<<<<.<<<<....>>>>.>>>>>>>>>>>>.>>>>>>....>>....>>>.>>>..>.....<<<<<..>>>>>..........>>>......>>>.>>>>>...>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<......>>>>>>>..<<<<<..<<<...<..............>...>>>...>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<........<<<.<<<<<<<<<...<<<....<<<..<.<<<...<<<<<.........>>>>>.>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.<......>>>>>>>>>.>..>>>>>>>>>>>>.>>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.....<.<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>.>.>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<.......>.>>>>>>....>>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<<<<<...>>>>>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<...<<<<<<<....>>>>>>>...<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<<<<<<<<<<<<..{{{..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>.>.>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<.>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>>..<<<.........>>>..........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<<.<<<<<<<<<<<<.<<<<..........<<<<<..<<<<..>>>>............>>>>>.>>>>.>>.>>>>>>>>>>...<<<<<.....<<<<....<..<<<<...>>>.>...>.............<<<<<<<......>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>>.<<<....>>>.>>))).......((((((..(((..>>>>>>.)))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]].....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<}}}.>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.....<<<<<<..<<..<<<...................<.<<<>>>.>..................<<<..<<<<.......<.<<<<<<<......>>>>>>>.>.....>>>>..>>>..............>>>...>>.>>>>>><<<<<.<.............>.....<.<<<<<<<.<<.....<<<<....<<<<<......>>>>>...>>>>....>>....>>>>.>>>.>...>>>>>... .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.....(.....((((.(.(.....).))))).......)......(.(...((.(...(.(.(....(....((.((.(......((........).).......(...)...(........).......).))))..).)..))...)))...).)..)....(((((((........))))))).....((.((..[[[[[[)).))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.......(..((.(...((.....((.(.(..(.....(..(((..(((.(....(.(((.(((..(((((((((.)))..)))))))))))).)))).).)).)....)...)..))...))....))...).))..)...(((((((.((((.(((((.(((........((.(((.(.((...(...(((((((.)))))))...).....))).)))))...........)))...))))).)))).....................((....(.((((()))).))..(.(((..(((..(...(..(((((((((...((...)).(((((((.((((....)))).)))))))))))).)))).)....).....))).)))..)......((((()))))...........)).......))).)))).....)))...)))))))).[((((........))))((((((....(((((((((((((..(((..((((..........)))..)..)))...((....))...(((((((......)))))))..(((((...((...(..............)...))....))))).((((..(((.((((......)))))))..)).))....)))))))))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((........)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((........(((.((((((((....(((....(((..(.(((..(..((..(.....)..)).).))).)..)))..)).)....))))))....((((((((.(......)))))))))....))))))))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.(.((((((((.......(((((.(((....(.........)....))).........((......))...)))))...)))))))).))))..........]]].)....))))))))))...)))))))((((((.(.......).))))))....)))))).(.((((((((.(.(.....((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((..(((((((....(.....)..))))))....[[(((.((...((....(((....)))..........((.((((.(.((...)).).))))))......))....))...(.(((........))).)]]((((....(((((...(((((((....)))))))..((((....)))...(...((((.(...(((((((((((((((((((((((..{{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....(((((((.......))))))))))).).))))))))))))(...)....).))))...)).........)).))).)))).))).))).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((.)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((....(((.....((((....)))).....))).))))..)))))(((.(.........).).)).......((.(......).(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.(((((((((.(((((.((((((.((((.......[..(((((..((((()))))..........].))))).)))).)).)))).)))))...(((((.....((((..(....(.((...))..)..)..............(((((((......)))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....)))))))...(((.(((((....{..)))).)))).(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))....))..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}}.)))))..)).))...))))...)))).((((...((((.............))))...))))..)))...).))))))......(((((..((..((.(.....................(()).....................(((...((......(.(.(((((.(......).)))))).).....))...)))..............)))...)).))))).(((((.(..(.......)..).....(.(((((((.((.....((((.(..(((((......)))))..)))))....))....)))).))).)...)))))... tRNA translocation by the eukaryotic 80S ribosome and the impact of GTP hydrolysis, Translocation-intermediate-POST-1 (TI-POST-1); 28S ribosomal RNA 6gz3 Bv 76 3.6 RF00005 URS0000868532_9986 30517857 0030533 9986 guuuccguaguguagugguuaucacguucgccuaacacgcgaaagguccccgguucgaaaccgggcggaaacacca <<<<<<<..<<<..........>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..(((..........))).(((((.......))))).....(((((.......)))))))))))).... tRNA translocation by the eukaryotic 80S ribosome and the impact of GTP hydrolysis, Translocation-intermediate-POST-1 (TI-POST-1); ap/P-site tRNA 6gz3 Bx 12 3.6 30517857 194966 guucguuaaaga ............ ............ tRNA translocation by the eukaryotic 80S ribosome and the impact of GTP hydrolysis, Translocation-intermediate-POST-1 (TI-POST-1); mRNA 6gz3 Bw 76 3.6 RF00005 URS000028779A_4932 30517857 0030533 0006412 4932 gcggacuuagcucaguugggagagcgccagacugaagaucuggagguccuguguucgauccacagaguucgcacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((.(((..((((.....[..)))).(((((.......))))).....(((((..]....)))))))).))).... tRNA translocation by the eukaryotic 80S ribosome and the impact of GTP hydrolysis, Translocation-intermediate-POST-1 (TI-POST-1); pe/E-site-tRNA 6gz3 B1 1708 3.6 RF01960,RF01959,RF00177 URS0000E60B9C_9986 30517857 0003735 0005840 9986 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucagaucaaaaccaacccgggcuuuggugacucuagauaaccucgggccgaucgcacgccccccguggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcggccccuugccucucgcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgacccccgagcgguaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccguggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<...[[[[>>>>>[[[.((((((.....{{.........[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[......{{....[[[[[....<<.....<<..<<.....>>..>>......>>.........<<<<...<<<<<<....>>>>>>...>>>>[[..(((((.....<<<<<<<<<<<.>>....<......>..)))))......]]...<<<<.<<<<......>>>>>>>>.]].]]]...}}....]]].<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>......}}.......<<<<<<<<<.<<<....>>>..>>>>>.>>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..)))))).]]]............{{.......{{...[[[.......<<<.....>>>....<.<.<<....>>>>....<<<<<.<.......<<...<.......>.<<<<.......>>>>...>>......>.>>>..>>............[..((((((.....>>>>>>>>>.))))))...]............<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...]]]...}}......<<<<<<....<...<<<<.<.....>.>>>>...>.>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<........>>>>>>>>>.>..>>>...<<..}}>>...>>.....>>>.....<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<........<<........>>..........<<<<<.<....<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<......>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<..<<..<......>..>>>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.....>.>>>>>......>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<.<<<<<..>>>>>...>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((...(....((....((..........))...)){)........((.......(((.(.(..(.....(((......((.....((..((.....))..))......))..........(((...(.((((....)))).)...))).....(((((......[[[[[[[[((.))....(......)..))))).........(.((((.((((......)))))))))...)))....)).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))..((.(((..........))).)).(.((....)).)...)))))).).......(((...(.((.}...))..))))..)...)).).....(.(((((((.(((....)))..))))).)).)......((..(...........)..)).........((((([.....(.((((.....((...])).......))))))))))..)))))).))).........(.({{...(.(.((...(((..(.....((.....)).....(....((..))..)....(.(((.(.......((..((.......)).(((.......)))....))......).)))....)...........(...((.((.....]]]]]]]]..)).))....)......)....(((((((..(...((((..(((.((((((((...((........))......)))))))).))).......((....))...))))..)..))).)))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..(.((((((.(((........))))))))).)..)))...((..}}))...)).....))))).).(((......((((....))))....)))...]]].](.(((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....((((((.......((.(((........))).)).....))))))...((.(((...(..(((((....(((.((.((....))...(.((......)))...)).)))....(((...(...(.((...(((...(..(......)..).)))...)).)..).....(((((.....)))))........)))....))).))......).))))).....).)))))...)).)))).))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....(.(((.((.......)).))).)......))...))))))))))..)..(.(..((.(..((((.((..(.((((((((.(((..(.((.((...(((((.(((((())))))...)))))...)).)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>........ tRNA translocation by the eukaryotic 80S ribosome and the impact of GTP hydrolysis, Translocation-intermediate-POST-1 (TI-POST-1); 18S ribosomal RNA 6gz3 A3 157 3.6 RF00002 URS0000005270_9986 30517857 0003735 0005840 9986 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>.............>>>..)...>>>....<<....>><<<<<<<.........>>>>>>>..................... .........................................((((((.[[....[)))...].(.(((......]].............)))..)...)))....((....))(((((((.........)))))))..................... tRNA translocation by the eukaryotic 80S ribosome and the impact of GTP hydrolysis, Translocation-intermediate-POST-1 (TI-POST-1); 5.8S ribosomal RNA 6gz3 A4 119 3.6 RF00001 URS000064027A_9986 30517857 0003735 0005840 9986 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcu .<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>.. .((((((((....((((((((.....((..((...(....)...))....))....)))))).))(((.((......((.((..((....)).)).)).....)).))))))))))).. tRNA translocation by the eukaryotic 80S ribosome and the impact of GTP hydrolysis, Translocation-intermediate-POST-1 (TI-POST-1); 5S ribosomal RNA 6gz4 A2 3612 3.6 RF02540,RF02543 URS0000E60BB6_9986 30517857 0003735 0005840 9986 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgcgcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcggcccggcggaucuuucccgcccccggggucggcgggggaccgucccccggaccggcgaccggccgccgccgggcgcauuuccaggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucggggcccccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcgcucuccccccugggggggccgggccaccccucccacggcgcgaccgcucucccagggggcggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccggggggccacgcgcgcgucccgggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgaggggcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcccacgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggccuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcuggcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacaugagagguguagaauaagugggaggcccgggccgccggugaaauaccacuacucugaucguuuuuucacugacccggugaggcgggggggcgagcccgaggggcucucgcuucuggcgccaagcgcccgcccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucgccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccgguccgggguccggugcggagugcccuucguccugggaaacggggcgcggccggaaaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuuguc .........................<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..[[[..<...<.....<<<<.<.........>>>>>.......>..>...<.<<..<<.<....<<<<<...<<...<<.<<.......<.<........>..>.................................>>>>.>>>>>.>>...>>>..>>.>.......<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<......>>>..................................<<<<<<<<..<<<.<.....<..<<.<.<<<<....<<.<..<.<<<....<...<<.<<<<......<<<<<.<<<..<<<<<<<<<.>>>..>>>>>>>>>>>>>>.>>.>>>>......>...>>>>..>.>>....>>>>.>.>>..>..<<<<<<<<.<<<<<<<<<<.<<<........<<.<<<.<<.<......<<<<<<<<.>>>>>>>>........>>>.>>>>>...........>>>...>>>>>>>>>>....................<<<....<<<<<<..>>>>>>..<.<<<..<<<.<<....<<<<<.<<<<<...<<...>>.<<<<<<<.<<<<....>>>>.>>>>>>>>>>>>.>.>>>>....>>....>>>.>>>..>.....<<<<<..>>>>>..........>>>......>>>.>>>>>...>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<......>>>>>>>..<<<<<..<<<...<..............>...>>>...>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<........<<<.<<<<<<<<<...<<<....<<<..<.<<<...<<<<<.........>>>>>.>>>.>..>>>..>.>>...>>>>>>>....<<<<<<<<.<......>>>>>>>>>....>>>>>>>>>>>>.>>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<.......>.>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<<<<<...>>>>>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<...<<<<<<<....>>>>>>>...<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<<<<<<<<<<<<..{{{..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>.>.>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<.>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<....<<<<<....>>>>.>...>>>.>>>>..>>>>>.<<<<<.......>>>>>.........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<<.<<<<<<<<<<<<.<<<<..........<<<<<..<<<<..>>>>............>>>>>.>>>>.>>.>>>>>>>>>>...<<<<<.....<<<<....<...<<<...>>>.....>.............<<<<<<<......>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>>.<<<....>>>.>>))).......((((((..(((..>>>>>>.)))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.<.....>.>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]].....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<}}}.>>>>>..>>.>>...>>>>...>>>><<<<....<<<<<...........>>>>>....>>>>.>>>...>.>>>>>>.....<<<<<<<..<..<<<...................<.<<<>>>.>..................<<<..<<<<.......<.<<<<<<<......>>>>>>>.>.....>>>>..>>>..............>.>>..>.>>>>>>><<<<<.<.............>.....<.<<<<<<<.<<.....<<<<....<<<<<......>>>>>...>>>>....>>....>>>>.>>>.>...>>>>>... .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.....(.....((((.(.(.....).))))).......)......(.(...((.(...(.(.(....(....((.((.(......((........).).......(...)....................).))))..).)..))...)))...).)..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.......(..((.(...((......(.(.(..(.....(..(((.((((.(....(.(((.(((..(((((((((.)))..)))))))))))).)))).)))).)....)...)..))...).....))...).))..)...(((((((.((((.(((((.(((........((.(((.((.(......((((((((.))))))))........))).)))))...........)))...))))).))))....................(((....((((((()))))))....(((..(((..(...(.((...(((((...((...)).(((((((.((((....)))).))))))))))))....)))....).....))).))).........((((()))))...........)))......))).)))).....)))...)))))))).[((((........))))((((((....(((((((((((((..(((..(((((........))))..)..)))...((....))...(((((((......)))))))..(((((...((...(..............)...))....))))).(((((.(((.((((......))))))).))).))....)))))))))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((........)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((........(((.((((((((....(((....(((..(.(((..(.(((..(.....)..)))).))).)..)))..)).)....))))))....((((((((.(......)))))))))....))))))))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.(.((((((((.......(((((.(((....(.........)....))).........((......))...)))))...)))))))).))))..........]]].)....))))))))))...)))))))((((((.(.......).))))))....)))))).(.((((((.(.(.(.....((((.((((....))))))))...))).))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((..(((((((....(.....)..))))))....[[(((.((...((..(.(((....))).....)....((.((((.(.((...)).).))))))......))....))...(.(((........))).)]]((((....(((((...((.((((....)))).))..((((....)))...(...((((.(...((((((((((((((((((.((((..{{{..)))).)....(((((.((((.((((.....(((.....))).....))))))))..))))).....(((((((.......))))))))))).).))))))))))))(...)....).))))...)).........)).))).)))).))).))).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((((.()))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.....((.....((((....)))).....))..))))..))))).((((.........))).)........((.(......).(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.(((((((((.((((((((((((.(((........[..(((((..((((()))))..........].)))))..))).)).))))))))))...(((((.....((((..(..(.(.((...))..).))..............(((((((......)))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....)))))))...(((.(((((....{..)))).)))).(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(.(.(((......))).)...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))....))..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}}.)))))..)).))...))))...)))).((((...((((.............))))...))))..)))...).))))))......(((((..((..((.(....(................(()).................)...(((...(((.....(.(.(((((.(......).)))))).)....)))...)))..............)).)..)).))))).(((((.(..(.......)..).....(.(((((((.((.....((((.(..(((((......)))))..)))))....))....)))).))).)...)))))... tRNA translocation by the eukaryotic 80S ribosome and the impact of GTP hydrolysis, Translocation-intermediate-POST-2 (TI-POST-2); 28S ribosomal RNA 6gz4 Bv 76 3.6 RF00005 URS0000868532_9986 30517857 0030533 9986 guuuccguaguguagugguuaucacguucgccuaacacgcgaaagguccccgguucgaaaccgggcggaaacacca <<<<<<<..<<<..........>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..(((..........))).(((((.......))))).....(((((.......)))))))))))).... tRNA translocation by the eukaryotic 80S ribosome and the impact of GTP hydrolysis, Translocation-intermediate-POST-2 (TI-POST-2); ap/P-site tRNA 6gz4 Bx 11 3.6 30517857 9986 uucguuaaaga ........... ........... tRNA translocation by the eukaryotic 80S ribosome and the impact of GTP hydrolysis, Translocation-intermediate-POST-2 (TI-POST-2); mRNA 6gz4 Bw 76 3.6 RF00005 URS000028779A_9986 30517857 0030533 0006412 9986 gcggacuuagcucaguugggagagcgccagacugaagaucuggagguccuguguucgauccacagaguucgcacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((.(((..((((.....[..)))).(((((.......))))).....(((((..]....)))))))).))).... tRNA translocation by the eukaryotic 80S ribosome and the impact of GTP hydrolysis, Translocation-intermediate-POST-2 (TI-POST-2); pe/E-site-tRNA 6gz4 B1 1708 3.6 RF01960,RF01959,RF00177 URS0000E60B9C_9986 30517857 0003735 0005840 9986 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucagaucaaaaccaacccgggcuuuggugacucuagauaaccucgggccgaucgcacgccccccguggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcggccccuugccucucgcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgacccccgagcgguaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccguggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<...[[[[>>>>>[[[.((((((.....{{.........[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[......{{....[[[{.....<<.....<<..<<.....>>..>>......>>.........<<<<...<<<<<<....>>>>>>...>>>>[[..(((((.....<<<<<<<<<<<.>>....<......>..)))))......]]...<<<<.<<<<......>>>>>>>>..}.]]]...}}....]]].<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<<..>>>.>...]]]]]].........<<<....<<<<...>>>>..>>>......}}.......<<<<<<<<<.<<<....>>>..>>>>>.>>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..)))))).]]]............{{.......{{...[[[.......<<<.....>>>...<.<<.<<<..>>>>>>...<<<<<.<.......<<...<.......>.<<<<.......>>>>...>>......>.>>>..>>.........[....(((((((.....>>>>>>>>>.)))))))....]..........<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<........>>>>>>>>>.>..>>>...<<..}}>>...>>.....>>>.....<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<.......<<........>>..........<<<<<.<....<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<..<<..<......>..>>>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.....>.>>>>>....>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<.<<<<<..>>>>>...>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((...(....((....((..........))...)){)........((.......(((.(.(..(.....(((......((.....((..((.....))..))......))..........(((...(((((......)))))...)))..(..(((((.....[[[[[[[[[((.))....(......)..)))))......)..(.((((.((((......)))))))))...)))....)).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))..((.(((..........))).)).(.((....)).)...)))))).).......(((...(.((.}...))..))))..)...)).).....(.(((((((.(((....)))..))))).)).)......((..(...........)..)).........((((([.....(.((((.....((...])).......))))))))))..)))))).))).........(.({{...(.(.((...(((..(.....((.....)).....(.(.(((..)))))....(.(((.(.......((..((.......)).(((.......)))....))......).)))....)...........(...((.(......]]]]]]]]]..).))....)......)....(((((((..(...((((..((..((((((((...((........))......))))))))..)).......((....))...))))..)..))).)))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..(.((((((.(((........))))))))).)..)))...((..}}))...)).....))))).).(((......((((....))))....)))...]]].](.(((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....((((((.......((.(((........))).)).....))))))....(.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((...(...((((...(((...(..(......)..).)))...))))..).....(((((.....)))))........)))....))).))).....).))))......).)))))...)).)))).))).(...((.(((........(.......((..((((....))))..))....).........))).))......(.....(((((..........))))).....)..)..))))).....(.(((.((.......)).))).)......))...))))))))))..)..(.(..((.(..((((.((..(.((((((((.(((..((((.((...(((((((((((..))))).).)))))...)).))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>........ tRNA translocation by the eukaryotic 80S ribosome and the impact of GTP hydrolysis, Translocation-intermediate-POST-2 (TI-POST-2); 18S ribosomal RNA 6gz4 A3 157 3.6 RF00002 URS0000005270_9986 30517857 0003735 0005840 9986 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>.............>>>..)...>>>....<<....>><<<<<<<<.......>>>>>>>>..................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))(((((((.........)))))))..................... tRNA translocation by the eukaryotic 80S ribosome and the impact of GTP hydrolysis, Translocation-intermediate-POST-2 (TI-POST-2); 5.8S ribosomal RNA 6gz4 A4 119 3.6 RF00001 URS000064027A_9986 30517857 0003735 0005840 9986 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>. .((((((((....((((((((.....((..((...(....)...))....))....)))))).))(((.((......((.((..((....)).)).)).....)).))))))))))).. tRNA translocation by the eukaryotic 80S ribosome and the impact of GTP hydrolysis, Translocation-intermediate-POST-2 (TI-POST-2); 5S ribosomal RNA 6gz5 A2 3612 3.5 RF02540,RF02543 URS0000E60BB6_9986 30517857 0003735 0005840 9986 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgcgcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcggcccggcggaucuuucccgcccccggggucggcgggggaccgucccccggaccggcgaccggccgccgccgggcgcauuuccaggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucggggcccccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcgcucuccccccugggggggccgggccaccccucccacggcgcgaccgcucucccagggggcggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccggggggccacgcgcgcgucccgggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgaggggcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcccacgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggccuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcuggcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacaugagagguguagaauaagugggaggcccgggccgccggugaaauaccacuacucugaucguuuuuucacugacccggugaggcgggggggcgagcccgaggggcucucgcuucuggcgccaagcgcccgcccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucgccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccgguccgggguccggugcggagugcccuucguccugggaaacggggcgcggccggaaaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuuguc .........................<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..[[[..<...<.....<<<<.<.........>>>>>.......>..>...<.<<..<<.<....<<<<....<<...<<.<<.<.....<.<........>..>...............................>.>>>>.>>.>>.>>...>>>..>>.>.......<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<......>>>..................................<<<<<<<<..<<<.<.....<..<<.<..<<<.....<<<..<..<<........<<.<<<<.<.....<<<<.<<<..<<<<<<<<<.>>>..>>>>>>>>>>>>>.>>>.>>>>..........>>.>..>.>>....>>>..>.>>..>..<<<<<<<<.<<<<<<<<<<.<<<........<<.<<<.<.<<...<..<<<<<<<<.>>>>>>>>..>.....>>>.>>>>>...........>>>...>>>>>>>>>>....................<<<....<<<<<<..>>>>>>....<<<..<<<.<<...<.<<<<<<<<<<...<<...>>.<<<<<<<.<<<<....>>>>.>>>>>>>>>>>>.>>>>>>....>>....>>>.>>>........<<<<<..>>>>>..........>>>......>>>.>>>>>...>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<......>>>>>>>..<<<<<..<<<...<..............>...>>>...>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<........<<<.<<<<<<<<<...<<<....<<<..<.<<<..<.<<<<.........>>>>>.>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.<......>>>>>>>>>.>..>>>>>>>>>>>>.>>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<.......>.>>>>>>....>>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<<....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<<<<<...>>>>>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<...<<<<<<<....>>>>>>>...<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<<<<<<<<<<<<..{{{..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>.>.>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<.<<<<<<<<<<<.>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<....<<<<<....>>>>.>...>>>.>>>>..>>>>>..<<<<.......>>>>..........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>...>>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<<.<<<<<<<<<<<<.<<<<..........<<<<<..<<<<..>>>>............>>>>>.>>>>.>>.>>>>>>>>>>...<<<<<.....<<<<....<..<<<<...>>>.>...>.............<<<<<<<......>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>>.<<<....>>>.>>))).......((((((..(((..>>>>>>.)))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]].....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<}}}.>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.....<<<<<<..<<..<<<.....<.............<.<<<>>>.>.............>....<<<..<<<<.......<.<<<<<<<......>>>>>>>.>.....>>>>..>>>..............>>.>..>>.>>>>>><<<<<.<.............>.....<.<<<<<<<.<<.....<<<<....<<<<<......>>>>>...>>>>....>>....>>>>.>>>.>...>>>>>... .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.....(.....((((.(.(.....).))))).......)......(.(...((.(...(.(.(....(....((.((.(......((........).).......(...)....................).))))..).)..))...)))...).)..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))...............((((....))))..................................((((((((..(((.......(..((.(...((......(.(.(..(.....(..(((..(((.(....(.(((.(((..(((((((((.)))..)))))))))))).)))).).)).)....)...)..))...).....))...).))..)...(((((((.((((.(((((.(((........((.(((.(.((.......(((((((.))))))).........))).)))))...........)))...))))).)))).....................((....(.((((())))).)....(((..(((..(...(.((((((((((...((...)).(((((((.((((....)))).)))))))))))).))))))....).....))).))).........((((()))))...........)).......))).)))).....)))...)))))))).[((((........))))((((((....(((((((((((((..(((..(((((........))))..)..)))...((....))...(((((((......)))))))..(((((...((...(..............)...))....))))).((((..(((.((((......)))))))..)).))....)))))))))))))..((.(...((((((.....((.((((((..((((...(((((((....)))))))...)[)))...(((..((.((........)))).)))....)))))).)).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((........(((.((((((((....(((....(((..(.(((..(...(..(.....)..)..).))).)..)))..)).)....))))))....((((((((.(......)))))))))....))))))))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.(.((((((((.......(((((.(((....(.........)....))).........((......))...)))))...)))))))).))))..........]]].)....))))))))))...)))))))((((((.(.......).))))))....)))))).(.((((((((.(.(.....((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((..(((((((....(.....)..))))))....[[(((.((...((....(((....)))..........((.((((.(.((...)).).))))))......))....))...(.(((........))).)]]((((....(((((...((.((((....)))).))..((((....)))...(...((((.(...((((((((((((((((((.((((..{{{..)))).)....(((((.((((.((((.....(((.....))).....))))))))..))))).....(((((((.......))))))))))).).))))))))))))(...)....).))))...)).........)).))).)))).))).))).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((.)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((....(((.....((((....)))).....))).))))..))))).((((.........))).)........((.(......).(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.(((((((((.(((((.(.((((.(((........[..(((((..((((()))))..........].)))))..))).)).)).).)))))...(((((.....((((......((.((...))..).)...............(((((((......)))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))(.((...(((((((.(.((((((.......))))))...).((...[[[))....)))))))...(((.(((((....{..)))).)))).(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))....))..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}}.)))))..)).))...))))...)))).((((...((((.............))))...))))..)))...).))))))......(((((..((..((.(....(................(())................)....(((..((((.....(.(.(((((.(......).)))))).)....))))..)))..............)).)..)).))))).(((((.(..(.......)..).....(.(((((((.((.....((((.(..(((((......)))))..)))))....))....)))).))).)...)))))... tRNA translocation by the eukaryotic 80S ribosome and the impact of GTP hydrolysis, Translocation-intermediate-POST-3 (TI-POST-3); 28S ribosomal RNA 6gz5 Bv 76 3.5 RF00005 URS0000868532_9986 30517857 0030533 9986 guuuccguaguguagugguuaucacguucgccuaacacgcgaaagguccccgguucgaaaccgggcggaaacacca <<<<<<<..<<<..........>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..(((..........))).(((((.......))))).....(((((.......)))))))))))).... tRNA translocation by the eukaryotic 80S ribosome and the impact of GTP hydrolysis, Translocation-intermediate-POST-3 (TI-POST-3); P/P-site-tRNA 6gz5 Bx 11 3.5 30517857 194966 uucguuaaaga ........... ........... tRNA translocation by the eukaryotic 80S ribosome and the impact of GTP hydrolysis, Translocation-intermediate-POST-3 (TI-POST-3); mRNA 6gz5 Bw 76 3.5 RF00005 URS000028779A_4932 30517857 0030533 0006412 4932 gcggacuuagcucaguugggagagcgccagacugaagaucuggagguccuguguucgauccacagaguucgcacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((.(((..((((.....[..)))).(((((.......))))).....(((((..]....)))))))).))).... tRNA translocation by the eukaryotic 80S ribosome and the impact of GTP hydrolysis, Translocation-intermediate-POST-3 (TI-POST-3); E/E-site-tRNA 6gz5 B1 1708 3.5 RF01960,RF01959,RF00177 URS0000E60B9C_9986 30517857 0003735 0005840 9986 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucagaucaaaaccaacccgggcuuuggugacucuagauaaccucgggccgaucgcacgccccccguggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcggccccuugccucucgcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgacccccgagcgguaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccguggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<...[[[[>>>>>[[[.((((((.....{{.........[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[......{{....[[[......<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<<<....>>>>>>...>>>>[[..(((((.....<<<<<<<<<<<.>>....<......>..)))))......]]...<<<<..<<<......>>>.>>>>....]]]...}}....]]].<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<<..>>>.>...]]]]]].........<<<...<<<<.....>>>.>>>>......}}.......<<<<<<<<<.<<<....>>>..>>>>>.>>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..)))))).]]]............{{.......{{...[[[.......<<<.....>>>...<<...<<....>>.>>...<<<<<.<.......<<...<.......>.<<<<.......>>>>...>>......>.>>>..>>............[.(((((((.....>>>>>>>>>.)))))))..]............<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<..}}>>...>>.....>>>.....<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<........<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<......>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<..<<..<......>..>>>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.....>.>>>>>......>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<.<<<<<..>>>>>...>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[..[[..))))(((.((((((...(.((..((.....(((.(((...(....((....((..........))...)){)........((.......(((.(.(..(.....(((......((.....((.(((.....))).))......))..........(((...((((((....))))))...)))......((((.....[[[[[[[[[((.))....(......)..))))..........(.((((.((((......)))))))))...)))....)).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))..((.(((..........))).)).(.((....)).)...)))))).).......(((...(.((.}...))..))))..)...)).).....(.(((((((.(((....)))..))))).)).)......((..(...........)..)).........((((([.....(.((((.....((...])).......))))))))))..)))))).))).........(.({{...(.(.((...(((..(.....((.....))....((.(..((..))).))...(.(((.(.......((..((.......)).(((.......)))....))......).)))....)...........(.(.((.(......]]]]]]]]]..).)).)..)......)....(((.(((..(...((((..((..((((((((...((........))......))))))))..)).......((....))...))))..)..)))..))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..(.((((((.(((........))))))))).)..)))...((..}}))...)).....))))).).(((......((((....))))....)))...]]..](.(((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((........((.(((........))).))......)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((...(.(.(..(...(((...(..(......)..).)))....).)).).....(((((.....)))).).......)))....))).))).....).))))).....).)))))...)).)))).))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....(.(((.((.......)).))).)......))...))))))))))..)..(.(..((.(..((((.((..(.((((((((.(((..(.((.((...(((((.(((((())))))...)))))...)).)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>........ tRNA translocation by the eukaryotic 80S ribosome and the impact of GTP hydrolysis, Translocation-intermediate-POST-3 (TI-POST-3); 18S ribosomal RNA 6gz5 A3 157 3.5 RF00002 URS0000005270_9986 30517857 0003735 0005840 9986 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>.............>>>..)...>>>....<<....>><<<<<<<<.......>>>>>>>>..................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))(((((((.........)))))))..................... tRNA translocation by the eukaryotic 80S ribosome and the impact of GTP hydrolysis, Translocation-intermediate-POST-3 (TI-POST-3); 5.8S ribosomal RNA 6gz5 A4 119 3.5 RF00001 URS000064027A_9986 30517857 0003735 0005840 9986 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcu .<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>.. .((((((((....((((((((.....((..((...(....)...))....))....)))))).))(((.((......((.((..((....)).)).)).....)).))))))))))).. tRNA translocation by the eukaryotic 80S ribosome and the impact of GTP hydrolysis, Translocation-intermediate-POST-3 (TI-POST-3); 5S ribosomal RNA 6gzq A1 2912 3.28 RF02540,RF02541,RF00002 URS000080E23D_300852 30301898 0003735 0005840 300852 ggucaagaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaacggcccgcacgcgggccgaaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggauguuggcuuagaagcagccaucauuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucuugacc ...<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<.))..))..>>.....>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<<<<<.....>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<......<<...<<....<<<<.<<<....<<<<......>>>>.(.......<<<......)>>>...>>>...>>>>.....>>..>>..>>>>>.>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...........................>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<.<...<<<<<<<<......<..........>.......>>>>>>>>..>..>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<....................................<......>....>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>....<<<<........>>>>.))<<<<<<<<<<<.....<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<..<.....>.>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>........>>>>>>>>>>>>>>>..>>.....<<......>>.>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<....<....>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<......<............<<<...............<..<........>...>.....................>>>...>......>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<.......>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<.]]]].>>>>>...>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<.......>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>... .(............((((.(((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(.(]]..]].).)......))))))...)))....(((....)))((((((((....)))))))).((((((.....)))))).))...((((((.....(...[..)......))))).).........(......)...((((......((.]...)).....))))...((([...((((((((.....))))))))....(.(((.((((.................((((.(((...((((........))))[[(...).(((.....]])))...)))...)))).............))))..)))]....(.((((((..[......))))).))....).(((((]..[.[)))))..)))......)).)))))).))...............((....))....)).........((((....)))).............).....))))).)))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))...(((.....)))............................)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((.(...(((((((((...(((...(((.((((....(...............)....)))).)))..)).)...)))))))))..)..))))))).)...((.((((.((......)).)))).)).....(((......)))...((((.(((...((([[....(.((((((.....(.....((..((((((((((.......((((....(...........[.......).......(............].)..))))...)))))))))).))...........]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((....(.....)..))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((.....((.(....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.(.......)))))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....).))........))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....))))).((((..(((((.....)))))..)))).(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(.(((((..(((...((...((((......))))...))...))))))))...))))(.(((.........))).)........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((...((((.(((.(((((.(((.(((((.(.(((.............................(.................)..........................)))..)))))).)))...(((((....)))))....))))).)))..))))...(((......[)))((((((..........]))))))([((...(((((((.(.((((.(........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....((.((((.((..].]...)))))).)).....)}......))))..))))))......((((....((((((...((.......))...)))))).....)).).)......(.((.((((((..((((...((......))...)..))).(((((.....))))).....)))))..)...))..).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((.(.}}.).))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.(...........)....(((((((((.......)))))....(((.((((.(((....(((((....)))))...)))..))))..)))...))))...)......). T. thermophilus hibernating 70S ribosome; 23S ribosomal RNA 6gzq B1 122 3.28 RF00001 URS00005AB4A7_300852 30301898 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga ..<<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<..<<<<....>>>>..>>...>...>>>.>>>>>>>>>>> ...((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((..((((....))))..)).......))).)))))))))). T. thermophilus hibernating 70S ribosome; 5S ribosomal RNA 6gzq A2 1506 3.28 RF00177,RF01959,RF01960 URS000080DEDF_300852 30301898 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggauc ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<......<<...........>>......>>>>>......<<.......<<<<<<<<..<<...<<<<<....<<<<....<<<<<......>>>>>.....>>>>.....<<<<.<<<<<....>>>>>.>>>>....<<.....>>....>>>>>..>>>>>>>>>><<<....<<...<<<<<<<<.......>>>>>>>>.>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>......<<.<<<....<<<<....>>>>..>>>>>>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<..))).>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<.<<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<....<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>.....>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<....<<<<<<..<<<<<<<<........<<........>>..........<<<<...................<<.<<<<....>>>>>>............................<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<...............>.....>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>.......>>>>......>>>>>>>>.....<<<<<.......<<<..<<..<<<<....>>>>..>>....>>>.......>>>>>......<..<.<<<<<<<........>>>>>>>>...>.....>>>>>>....<<<<<<<..........>>>>>>>...........>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>..... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..(........[..........(]..).....))))......(((......(.(..(((..((......((....((((......((((....)))).......)))).....((((.(((((....))))).))))...((.......))...)).....)))))..).)(((....(.....(((((((.......)))))))...)......)))..((((((((....))))...))))))).(((((.(.........)))))).((((....))))...)))))).).....(.(((...(..((....))...))))).)).))))))..(.((......((((....)))).....)).)....(((((...(......((.....)).......)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.(..(....((.(((......(((((((((......((((((.....))))))....))))))))..).....)))..((......(...(.(((.......((((((....((........)).......))))))............((....))...))).)..).......)..)))....)..)....(((.((...((...((((.........))))...)))).)))......{...((((((..((((((...(...)...))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((...(((((((.(...(((.(..((((.(((........((........))..........(......................(..((((....)))).)...............................(((....(((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((....(......(.....)....).....))))).....(((((....)))))........)))).....).).)))...)..)))............)......))).)))).(...(((((.......(.(..((..(.((....)).)..))....).).......)))))......(....(((((((........)))))))....)..)..).))).......(.((............)).).........)...)))))))..).))..(.(..((.(.((((...(..(...(((...(((.....((((....(((....))).))))....)))...)))...)..)...))))..).))...)..)..(((((((((....)))))))))}.... T. thermophilus hibernating 70S ribosome; 16S ribosomal RNA 6gzx A1 2912 4.57 RF02540,RF02541,RF00002 URS000080E23D_300852 30301898 0003735 0005840 300852 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...<.<<.......<<<<<<<<<<<.........<<.<<<<.<..<......<<<<<<.....(..>>>.....<<<<<<<..<<<.).....>>>.....>>>>>>>...>>>....<.<....>.><<<<<<<......>>>>>>>.<<<<<.......>>>>>.>.....<<<<<...................>>>>>...........<<....>>....<<<<.....<<.....>>....>>>>....<<<....<<<<<<<<.....>>>>>>>>......<<.<<<.<.......<.........<<<<.<<.....<<<........>>>.((......<<<.....))>>>....>>...>>>>.........>...>.>>>..>>.....<<<<<<<...........>>>>>>>.......<<<<..((((>>>>...>>>.......>..>>>>..>>...............<<....>>...............<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>..................<<<<<<....<<<<<<<<<<<<<..<<<...<<.......>>...>>>...<<....>>..<<<.......>>>...........................>>>>>>>>>>>>>..<<.....<<<<<<......<<<<<<<<...<<....<<<<<<......>>>>>>.....>>.....<<...<<<........>>.>.>>.....>>>>>>>>.....<<.....>.>......>>>>>>........>>..<<<<<<....<<<<<....>>>>><<.<<<<<<.....<<<<<<.<<...<<<....<<<<<<<.....<...........>.......>>>>>>>...>>.>...>>.>>>>>>.....>>>>>.>.>>..<<<<<<<.<<......>>.>>>>>>>......<<......>>....<<<<.<<<...<<<((.(....<<<<.............<<..<<<<.<<<.........<<<<..................................................>>>>.....>>>.>>>>.>>..........)))........>>>>.>>>...>>>>>>>..<.<<<<.....>>>>..>.....>>>>>><....<....<<<......<<<<<.<<<....>>>>>>>>...>>>...>.....>.....>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<..<<....<<<<<.............>>>>>.....((<<<<.<<...<.<...<<<....>>>...>.>...>>....<<<<........>>>>.)).<<<<<<<<.......<<<<.....<<<.....<.<<<<<.<<<<.<<.........>>>>>>.......<<<<<<..<<<<<<<..........>>>>>>>.......>>>>>>..........<..........>......>>>>>...>.....>>>..........>>>>..........>>>>>>>>.>>>>..>>.....<<......>>.>>>>.<<<<......>>>>..>>>>...<<<....<<<<<<<<..<...............<<<<<....<<..>>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<......................>>>>>>>...<<<.<<<..<<<<<<<..<<<...<....<<<<<....>>>>>....>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>....>>.>>>>>>>.....>..>>>>>>>>.>>>.>>...........<<<<<........>>>>>..<<<<<<<<.<<<..........<<<.<<.<<<..<<<<<.<<<.<<<<<.<<<<<<......................................<<..............>>....................................>>>>>>...<<<<......>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<....<<<<<<...<<<<.<.......>.>>>>.....<.....((.>....>>>>>>....<<<..................>>>.<<......>>.>>)).........<<<<<<.<<..))))..>>>>>>>>..............>>>...>>>>>........<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.........<<<..<<<<...<<<<<<<<........>>>>>..>>>.<<<<<.....>>>>>......>>>>......>>>.......<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<.<<<<......>>>>....>>>>>...>>>>.>>>>>...<<<....<.<<<...........>>>..>...>>>.>>>>.......>>>>>>>..<<<.......>>>....<<<<<<<<<.......>>>>>....<<<.<<<<.<<<.....<<<<....>>>>....>>>..>>>>..>>>...>>>>.....>>.>... 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T. thermophilus hibernating 100S ribosome (ice); 23S ribosomal RNA 6gzx B1 122 4.57 RF00001 URS00005AB4A7_300852 30301898 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga ...<<<<<<<.<..................<<<<<...............>>>..>>.............<<<...........<<<<....>>>>...........>>>..>.>>>>>>>. .....((.(..((.....(.(.(.........((.................))..........)..).)............(...(((....)))....)...........))..).))... T. thermophilus hibernating 100S ribosome (ice); 5S ribosomal RNA 6gzx A2 2912 4.57 RF02540,RF02541,RF00002 URS000080E23D_300852 30301898 0003735 0005840 300852 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......<.......<<<<<<<<<<<.........<<.<<<<.<<<<......<<<<<<.[...((.>>>.....<<<<<<<..<<<))...].>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<.......>>>>>.>>....<<<<<...................>>>>>...........<<....>>....<<<<.....<<.....>>....>>>>....<<<....<<<<<<<<.....>>>>>>>>......<<..<<<<...........<.......<...<<....<<<........>>>.((......<<<.....))>>>...>>.....>........>......>>>>...>>.....<<<<<<<<.........>>>>>>>>......<<<<.....<<.>>>>..>>>......>>..>>>>..>>...............<<....>>...............<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>..................<<<<<<....<<<<<<<<<<<<...<<<...<<.......>>...>>>...<<....>>..<<<<.....>>>>............................>>>>>>>>>>>>..<<.<...<<<<<<......<<<<<<<<...<<....<<<<<<......>>>>>>.....>>.....<<...<<<........>>.>.>>.....>>>>>>>>......<.....>........>>>>>>.......>>>..<<<<<<....<<<<<....>>>>><.<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<.<.....................>.>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>.>.>>..<<<<<<<.<<......>>.>>>>>>>......<<......>>....<<<<.<<<...<<<(((.....<<<<..<..........<<..<<<<<<<<<........<.<.....................................<........>.....>.>....>>>>>>>>>.>>..........)))......>.>>>>.>>>...>>>>>>>...<.<<<.....>>>..>......>>>>>><..<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>.>..>.....>>>>>>.......<<.....<<<<.<........>>>>>.<<<....<<<<<.<.<...<<<<<.............>>>>>.....((.<<<.<<...<.<...<<<....>>>...>.>...>>....<<<<........>>>>.))<<<<<<<<<<<.....<<<<.....<<<..<<.<.<<<<<.<<<<.<<.........>>>>>><<<....<<<<<<...<<<<.<..........>.>>>>........>>>>>>...>>>....<<<<....>>>>......>>>>>...>>>...>>>..........>>>>........>>>>>>>>>>>>>>...>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>....<<<....<<<<<<<<..<.........<.....<<<<<....<....>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<....<<.<........>>>..<<<<<<<......<.......>.......>>>>>>>...<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>.......>>>>>>>..>..>..>>>>>>>>.>>>.>>...........<<<<..........>>>>..<<<<<<<<.<<<..........<<<.<<.<<...<<<<<.<<<.<.<<<.<<<<<<............................................................................................>>>>>>...<<<<......>>>>....>>>.>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<....<<<<<<...<<<<.<.......>.>>>>.....<.....((.>....>>>>>>....<<....................>>.<<......>>.>>)).........<<<<<<.<<..>>....>>>>>>>>...............>>...>>>>.>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<.<<<.<<<<<...<<<<<<<..........>>>>..>>>.<<<<<.....>>>>>......>>>>..>...>>>..>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<.<....<<<<..<<<<<<<...............>>>>>>>.<<<<<....<.<...<<<<<.<<<<......>>>>....>>>>>...>.>..>>>>>...<<<....<<<<<...........>>>>.>...>>>.>>>>........>.>>>>..<<.........>>....<<<<<<<<<.......>>>>>....<<<.<<<<.<<<....<<<<<....>>>>>...>>>..>>>>..>>>...>>>>.....>...... 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T. thermophilus hibernating 100S ribosome (ice); 23S ribosomal RNA 6gzx B2 122 4.57 RF00001 URS00005AB4A7_300852 30301898 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga ...<<<<<<<.<.....<...<<..........<<...............>>...........>>....><<<........<..<<<<....>>>>..>........>>>..>.>>>>>>>. .....((((..((.....(....................(.....)......................).(.............((((....)))).............).))..))))... T. thermophilus hibernating 100S ribosome (ice); 5S ribosomal RNA 6gzx A3 1506 4.57 RF00177,RF01959,RF01960 URS000080DEDF_300852 30301898 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggauc .....<<<..[.(((..>>>..<<<<.<<<<<..<<<<<<<......<<<.......<<..<<...........................>>>>.......<<.......<<<<<<<...<<...<<.......<<.<.....<<<........>>>.......>>>.....<<<<.<<<<<....>>>>>.>>>>....<.......>.......>>..>>.>>>>>>><<<..........<<<<<<<.......>>>>>>>..........>>>..<<<<<<<<....>>>...>>>>>.>>..<<<<............>>>>..<<<<<..>>>>>......>>>.......<.<<<....<<<......>>>..>>>>..>.>>>>>>..<<<<.......<<......>>......>>>>....<<<<<........<<<.......>>>..........>>>>>......<<<<.((....<<<<<.........)).........>>>>>.>>>>..>>>>>>>>>...........<.((.....<<<<...<<<.<<<<<..<<<<<<<<<........<<<<<<.....>>>>>>......>>>>>>..>>>.>>>>>.........<<...<<<<<<<....<<<<<<<..<.<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>..........>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<.<<<<...>>>>.>>>>>...<<..))>>.....>>>>>>..>...<.......<<<<....>>>>.....>....))).].<.<<.<<<<<<<.<<..<<<<...<<<<<<<<........<<........>>...........<<<.......................<<......>>...............................<..<<<..<<<<.<<.......<<<<.<<<....>>>..<<<<......>>>>...>>>>......<<<...<........<..............>...........>......<<<......>>>..........>>>.......>.>.>...>>>>>>..>......>>>.......>>>>>>>>.....<<<<........<<...<<...<<<....>>>...>>.....>>........>>>>.........<.<<<<<............>>>>>>..........>>>>......<<<<<<..........>>>>>>.......>>...>>>>>>>>>..>........<<...<<<<.<<<..<<.<<<<..<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>..>>>>.>>..>>>.>>>>....>>.........<<<<.<<<<....>>>>.>>>>..... .....[[...(.((....]]..........((..(..((((.......(....(..(((..((...........................)))))......(((...........(....((............(..(......((.(....).).)......)..)......(.....((......)).....)....((.......))..........))..).....(((...........(((.((.......)).)))...........)))..(.((.((...[..))....).)))))..((((............))).)..(((....)))....)...)........(........((.(....).)).....)..).)))..)...(((......(((......))).....))).......(.(...(....((((.....)))).....)....).)........(.(.([.....((.((.....((...])).......)).))).).)..))...............]....[[.....(..(...((...((......(.(((.(........((((((.....))))))......).)))...).....))...(.............(((.......((((((....((........)).......))))))............((....))...)))...............).))...)..)....(.((.(...((......(.........)......))).)).)......{.....((.(..(..(((..((...))..)))..).......]].......).)).................(((....)))............)).).......(((.(..(...(((((...((((...(.......(..........)...........(.(..............(....(...(........)..).....................).........((.....((.((.(.....(((.((.(....).)....((......))....).)))...........(.(................................)..).......(......)....................).).).)...)...)).........)..)......)..))))......((..(.......(.(..((....(......)....))....).).......)..)).............((..............))............))))).......((((............)))).........)....).))).........(.........((((...(......((.(..........(((.....(((....)))..)))..........)))......)...))))............)..((.(...((....))...).))}.... 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T. thermophilus hibernating 100S ribosome (amc); 23S ribosomal RNA 6gzz B1 122 4.13 RF00001 URS00005AB4A7_300852 30301898 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga ..<<<<<<<<<<.....<<.<<<......<<<<<<...............>>>..>>>.....>>>..>><<<.......<<....<<....>>....>>.......>>>..>>>>>>>>>> ...(((((((((.....((..(..........................................)...))(.(..............(....)..............).)..))))))))). T. thermophilus hibernating 100S ribosome (amc); 5S ribosomal RNA 6gzz A2 2912 4.13 RF02540,RF02541,RF00002 URS000080E23D_300852 30301898 0003735 0005840 300852 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.....<<<........<<<<<<<<<.....<<..<<.<<<....<<......<<<<<<.(......>>>.....<<<<<<<..<<<.....).>>>.....>>>>>>>...>>>....<<<....>>>.<<<<.<......>.>>>>..<<<<<.......>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<.......>>>>>>>......<<<..<<<......<<...........<<.<<<....<<..........>>.((......<<<.....))>>>...>>>...>>...........>>..>>>...>>>.....<<<<<<<<.........>>>>>>.>>.....<<<<<..((((>>>>>..>>>...........>>>..>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>.........<<<<<<<<<<<....>>>>>>>>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<...<<....<<<.....>>>....>>...<<....>>..<<<<.....>>>>............................>>>>>>>>>>>>..<<....<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>....>>..<<<<<<....<<<<<....>>>>><<.<<<<<<.....<<<<<<<<<....<<....<<<<<.<...<.................>....>>>>>>...>>.....>>>>>>>>>.....>>>>>.>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<((......<<<<<<...........<<..<<<<<<<<<......<........<.....................>.............................>..>>>>>>>>>.>>...........))......>>>>>>.>>>...>>>>>>><<<..<<<.....>>>..>>>....>>>>>><<<<<.<...<<<......<<<<<.<<<....>>>>>>>>...>>>...>>>>.>>.....>>>>>><......<......<<<<<.........>>>>><<<<....<<<<<.<<...<<<<<....<<.....>>..>>>>>....((<<<<.<<...<<<....<<....>>....>>>...>>....<<<<........>>>>.))<<<.<.<..<..............<<<<..<<....<<<..<<<<.....[[[......>>>><<....<<<<<<<..<<<<.<..<.......>.>.>>>>.......>>>>>>>...>.>......<.....>.........>>>.....>>...>>>>.......................>.>..>>>>>>>>..>>.....<<......>>>>>>>.<<<........>>>..>>>>...<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<<....<.....>....>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>..<<<<.<<<..<<<<<<<...<<...<<...<<<<......>>>>...>>...>>.>>>>>..>>>>>...........................<...........<<<<<<.....>>>>>>.....>....>>>>...>>.>>>>>>>.....>>.>>>>>>>>.>>>..>.....>.....<<<<..........>>>>..<<<<<<<<.<<<.........<<<<.<..<<<..<<<<..<<<.<<<<..<<<<<<<.....<..................................<..........>................................>.....>>>>>>>...<<<<<....>>>>>.....>>>>.>>>...>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<....(((.>....>>>>>>>....<.....<<......>>......>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>....>>>>>.......<<<<...<<<<<<.<..<.......>...>>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<..]]].>>>>>...>>>>>...>>>>.>>>>>...<<<.<..<<<...............>>>...>>>>.>>>>.......>>>>>>>...................<<<<<<<.<........>>>>....<<<.<<<<.<<.....<<<<<....>>>>>....>>..>>>>..>>>...>>>>....>>>..... 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T. thermophilus hibernating 100S ribosome (amc); 23S ribosomal RNA 6gzz B2 122 4.13 RF00001 URS00005AB4A7_300852 30301898 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga ...<<<<<<<.......<<.<<<.......<<<<<...............>>>..>>......>>>..>><<<...<...<<....<<....>>....>>.....>.>>>....>>>>>>>. ....((((.(.(.....((..(..........................................)...))((........((.....(....).....))........))..).).)))).. T. thermophilus hibernating 100S ribosome (amc); 5S ribosomal RNA 6gzz A3 1506 4.13 RF00177,RF01959,RF01960 URS000080DEDF_300852 30301898 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggauc ....<<<<....(((..>>>>.<<...<<<<...<<<<<<<......<<<.<<<..<<<..<<...........................>>>>>......<<.......<<<<<<<<..<<...<<<<<....<<<.....<<<<<......>>>>>......>>>.....<<<<.<<<<<....>>>>>.>>>>....<......>.....>>>>>..>>>>>>>>>><<<.....<....<<<<<<<.......>>>>>>>..>.......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<........>>...>>>>>>......<...<<....<<<<....>>>>..>>..>.>.>>>>>>..<<<<......<<<......>>>.....>>>>...<<<<<<......<.<<<<.....>>>>..>.......>>>>>.>....<<<<<(((...<<<<<.....<..))).>.......>>>>>>>>>>...>>>>..>>..........<<<((.....<<<<...<<<.<<<<....<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>..>>>...>>>>....<...<<.....<<<<<<....<<<<<<<....<<........>>.......>>>>>>>...........<......>.>>>>>>...>>.....>....>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>...)))..<<<<<.<<<<<<<....<<<<<<...<<<<<<<........<<........>>..........<<<<.......................<........>...............................<.......<<<<<<<.......<<<<<<<<....>>>..<<<<......>>>>..>>>>>......<<<<.<<<<<<<...<..............>.....>>>>>>>.....<<<<<....>>>>>........>>>>.......>.>>>...>>>.....>......>>.>>.....>>>>>>>......<<<<.........<...<...<<<<....>>>>...>.....>.........>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>.....<<<<<............>>>>>............>>>>>>>>>>.>>....<..<<...<<<<.<<<..<<<<<<<<<<<<<...<..<<.....<........>..>>..>..>>>>>>>>>>>>>..>>>.>>>>....>>...>.....<<<<<<<<<....>>>>>>>>>..... ....((((..[.[[[..)))).(....(((((..((..((.((.....((..(...(((..((...........................)))))......(((......(....(((..((......(.....((((......((.(....).)).......)))).....((((.(.(((....))).).))))...(.........)....).....)))))....).((..........(((((((.......)))))))..........))....(((((((....))))...))).))).((.(..............).))....(.....)......).))..)........((...(((.(....).)).)))...)..))..))..((((.......((......))......)))).....(((..........(((.....)))............))).......((.((.[[...(((.(.....(..]]..).......).))))).))..)))))...)..........((([[...(.(..(....((.(.(........(((..((......(((.((.....)).)))....))..))).........).)..((..(.........(.((........(((......(........).........)))........................)).)........)...)..)).)...)..)....((..((...((...((((.........))))...))))..))...........((((...((((((((((...))))))))))...(...]].)......)))).)))).(.........(.(....).).......)...]]].](((....((((.......(......(.(..(.(........(..........).............(.......................(........)............................................(..(....((..(((((....)))...((........))...))..))......(...(((..................(.......).....))).....(((........)))...........).....)...).....................)........).)..).).(....(.((........((..((....((....))....))....))........)).).......(....(.(((((........))))).)....)..)......).....(((((..............))))).............))))...).))..(.(..(..(.((((...(......(((...(((...(...((...............))...)..)))...))).......)..))))..)..)...)..)..(((((.(((....))).)))))..... T. thermophilus hibernating 100S ribosome (amc); 16S ribosomal RNA 6h4n a 1534 3.0 RF00177,RF01959,RF01960 URS0000D7793B_679895 30177741 0003735 0005840 679895 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucac .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<<....>>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>.............>>>>>.>>.<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>....... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((........))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....))))))).............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}...... Structure of a hibernating 100S ribosome reveals an inactive conformation of the ribosomal protein S1 - 70S Hibernating E. coli Ribosome; 16S ribosomal RNA 6h4n A 2900 3.0 RF02540,RF02541 URS0000B21DDD_679895 30177741 0003735 0005840 679895 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugucgaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccgggagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccguaaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<<..>>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<....>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<.....<.........>.....>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<..........>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.......<<<<<..<<....>>...>>>>>.......>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<...<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<..<<...........<<<<....>>>>........>>............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>.(<<...<<<<<<<...<<<<<<.......>>>>>>.....<<)..(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>....>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[......(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))..(((((((..((((((((((.....(((...(((.((((...((..((....))...))...)))).)))..)).).....)))))).)))..)))))))).....(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.((....(............)...)).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((..........))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((....(((....])))....)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((..(((((..(((((.(((.(((((.((((((.((((.((((.(.........(((((..((..........(.(((....))).).......))............)))))).)))).)))).))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....(.][.[[[.)....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..).))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Structure of a hibernating 100S ribosome reveals an inactive conformation of the ribosomal protein S1 - 70S Hibernating E. coli Ribosome; 23S ribosomal RNA 6h4n B 120 3.0 RF00001 URS00008116C5_679895 30177741 0003735 0005840 679895 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Structure of a hibernating 100S ribosome reveals an inactive conformation of the ribosomal protein S1 - 70S Hibernating E. coli Ribosome; 5S ribosomal RNA 6h4n w 77 3.0 RF00005 URS0000D77936_679895 30177741 0030533 0006412 679895 cgcgggguggagcagccugguagcucgucuggcucauaaccagaagaucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(.(((..]....))).)))))))..... Structure of a hibernating 100S ribosome reveals an inactive conformation of the ribosomal protein S1 - 70S Hibernating E. coli Ribosome; tRNA 6h58 A 2900 7.9 RF02540,RF02541 URS0000B21DDD_679895 30177741 0003735 0005840 679895 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugucgaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccgggagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccguaaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<<..>>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<....>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<.....<.........>.....>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<..........>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.......<<<<<..<<....>>...>>>>>.......>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<...<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<..<<...........<<<<....>>>>........>>............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>.(<<...<<<<<<<...<<<<<<.......>>>>>>.....<<)..(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>....>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[......(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))..(((((((..((((((((((.....(((...(((.((((...((..((....))...))...)))).)))..)).).....)))))).)))..)))))))).....(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.((....(............)...)).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((..........))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((....(((....])))....)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((..(((((..(((((.(((.(((((.((((((.((((.((((.(.........(((((..((..........(.(((....))).).......))............)))))).)))).)))).))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....(.][.[[[.)....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..).))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Structure of a hibernating 100S ribosome reveals an inactive conformation of the ribosomal protein S1 - Full 100S Hibernating E. coli Ribosome; 23S ribosomal RNA 6h58 B 120 7.9 RF00001 URS00008116C5_679895 30177741 0003735 0005840 679895 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Structure of a hibernating 100S ribosome reveals an inactive conformation of the ribosomal protein S1 - Full 100S Hibernating E. coli Ribosome; 5S ribosomal RNA 6h58 a 1539 7.9 RF00177,RF01959,RF01960 URS000080DDC0_679895 30177741 0003735 0005840 679895 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<<....>>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>.............>>>>>.>>.<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((........))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....))))))).............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Structure of a hibernating 100S ribosome reveals an inactive conformation of the ribosomal protein S1 - Full 100S Hibernating E. coli Ribosome; 16S ribosomal RNA 6h58 w 77 7.9 RF00005 URS0000D77936_679895 30177741 0030533 0006412 679895 cgcgggguggagcagccugguagcucgucuggcucauaaccagaagaucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(.(((..]....))).)))))))..... Structure of a hibernating 100S ribosome reveals an inactive conformation of the ribosomal protein S1 - Full 100S Hibernating E. coli Ribosome; tRNA Mixture 6h58 AA 2900 7.9 RF02540 URS0000B21DDD_679895 30177741 0003735 0005840 679895 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugucgaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccgggagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccguaaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<<..>>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<....>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<.....<.........>.....>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<..........>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.......<<<<<..<<....>>...>>>>>.......>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<...<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<..<<...........<<<<....>>>>........>>............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>.(<<...<<<<<<<...<<<<<<.......>>>>>>.....<<)..(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>....>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[......(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))..(((((((..((((((((((.....(((...(((.((((...((..((....))...))...)))).)))..)).).....)))))).)))..)))))))).....(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.((....(............)...)).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((..........))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((....(((....])))....)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((..(((((..(((((.(((.(((((.((((((.((((.((((.(.........(((((..((..........(.(((....))).).......))............)))))).)))).)))).))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....(.][.[[[.)....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..).))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Structure of a hibernating 100S ribosome reveals an inactive conformation of the ribosomal protein S1 - Full 100S Hibernating E. coli Ribosome; 23S ribosomal RNA 6h58 BB 120 7.9 RF00001 URS00008116C5_679895 30177741 0003735 0005840 679895 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Structure of a hibernating 100S ribosome reveals an inactive conformation of the ribosomal protein S1 - Full 100S Hibernating E. coli Ribosome; 5S ribosomal RNA 6h58 aa 1539 7.9 RF00177,RF01959,RF01960 URS000080DDC0_679895 30177741 0003735 0005840 679895 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<<....>>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>.............>>>>>.>>.<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((........))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....))))))).............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Structure of a hibernating 100S ribosome reveals an inactive conformation of the ribosomal protein S1 - Full 100S Hibernating E. coli Ribosome; 16S ribosomal RNA 6h58 ww 77 7.9 RF00005 URS0000D77936_679895 30177741 0030533 0006412 679895 cgcgggguggagcagccugguagcucgucuggcucauaaccagaagaucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(.(((..]....))).)))))))..... Structure of a hibernating 100S ribosome reveals an inactive conformation of the ribosomal protein S1 - Full 100S Hibernating E. coli Ribosome; tRNA Mixture 6h61 X 15 4.02 URS0000E60B84_10879 30449722 10879 uccaugcgcaugacg ............... ............... CryoEM structure of the MDA5-dsRNA filament with 89 degree twist and without nucleotide; RNA (5'-R(P*UP*CP*CP*AP*UP*GP*CP*GP*CP*AP*UP*GP*AP*CP*G)-3') 6h61 Y 15 4.02 URS0000E60BC3_10879 30449722 10879 cgucaugcgcaugga ............... ............... CryoEM structure of the MDA5-dsRNA filament with 89 degree twist and without nucleotide; RNA (5'-R(P*CP*GP*UP*CP*AP*UP*GP*CP*GP*CP*AP*UP*GP*GP*A)-3') 6h66 X 15 4.16 URS0000E60B84_10879 30449722 10879 uccaugcgcaugacg ............... ............... CryoEM structure of the MDA5-dsRNA filament with 93 degree twist and without nucleotide; RNA (5'-R(P*UP*CP*CP*AP*UP*GP*CP*GP*CP*AP*UP*GP*AP*CP*G)-3') 6h66 Y 15 4.16 URS0000E60BC3_10879 30449722 10879 cgucaugcgcaugga ............... ............... CryoEM structure of the MDA5-dsRNA filament with 93 degree twist and without nucleotide; RNA (5'-R(P*CP*GP*UP*CP*AP*UP*GP*CP*GP*CP*AP*UP*GP*GP*A)-3') 6ha1 A 2887 3.1 RF02540,RF02541,RF00002 URS00005906D8_224308 30126986 0003735 0005840 224308 guuaaguuagaaagggcgcacgguggaugccuuggcacuaggagccgaugaaggacgggacgaacaccgauaugcuucggggagcuguaagcaagcuuugauccggagauuuccgaauggggaaacccaccacucguaauggagugguauccauaucugaauucauaggauaugagaaggcagacccggggaacugaaacaucuaaguacccggaggaagagaaagcaaaugcgauucccugaguagcggcgagcgaaacgggaucagcccaaaccaagaggcuugccucuugggguuguaggacacucgaacgagguagaugaagaggucuggaaaggcccgccauaggagguaacagcccuguagucaaaacuucguucgaguggauccugaguacggcggaacacgugaaauuccgucggaauccgggaggaccaucucccaaggcuaaauacucccuagugaccgauagugaaccaguaccgugagggaaaggugaaaagcaccccggaaggggagugaaagagauccugaaaccgugugccuacaaguagucagagcccguuaacgggugauggcgugccuuuuguagaaugaaccggcgaguuacgaucucgugcaagguuaagcagaagaugcggagccgcagcgaaagcgagucugaauagggcgcaugaguacguggucguagacccgaaaccaggugaucuacccauguccagggugaaguucagguaacacugaauggaggcccgaacccacgcacguugaaaagugcggggaugagguguggguaggggugaaaugccaaucgaaccuggagauagcugguucucuccgaaauagcuuuagggcuagccucaagguaagagucuuggagguagagcacugauuggacuaggggccccuaccggguuaccgaauucagucaaacuccgaaugccaaugacuuauccuugggagucagacugcgagugauaagauccguagucgaaagggaaacagcccagaccgccagcuaaggucccaaaguauacguuaaguggaaaaggauguggaguugcuuagacaaccaggauguuggcuuagaagcagccaccauuuaaagagugcguaauagcucacuggucgagugacucugcgccgaaaauguaccggggcuaaacguaucaccgaagcugcggacuguucgaacagugguaggagagcguucuaagggcugugaagccagaccggaaggacugguggagcgcuuagaagugagaaugccgguaugaguagcgaaagaggggugagaauccccuccaccgaaugccuaagguuuccugaggaaggcucguccgcucaggguuagucgggaccuaagccgaggccgaaaggcguaggcgauggacaacagguugauauuccuguaccaccuccucaccauuugagcaauggggggacgcaggaggauaggguaagcgcgguauuggauauccgcguccaagcaguuaggcugggaaauaggcaaauccguuucccaaaggcugagcugugauggcgagcgcgaaguuccugauuccacacugccaagaaaagccucuagcgaggugagaggugcccguaccgcaaaccgacacagguaggcgaggagagaauccuaaggugaucgagagaacucucguuaaggaacucggcaaaaugaccccguaacuucgggagaaggggugcucuguuagggugcaagcccgagagagccgcagugaauaggcccaggcgacuguuuagcaaaaacacaggucucugcgaagccguaaggcgaaguauaggggcugacgccugcccggugcuggaagguuaagaggagcgcuuagcguaagcgaaggugcgaauugaagccccaguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgacccgcacgaaaggcgcaacgaucugggcacugucucaacgagagacucggugaaauuauaguaccugugaagaugcagguuacccgcgacaggacggaaagaccccguggagcuuuacugcagccugauauugaauguugguacagcuuguacaggauagguaggagccuuggaaaccggagcgccagcuucgguggaggcaucggugggauacuacccuggcuguauugaccuucuaacccgccgcccuuaucgggcggggagacagugucaggugggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguucccucagaaugguuggaaaucauucgcagaguguaaaggcacaagggagcuugacugcgagaccuacaagucgagcagggacgaaagucgggcuuagugauccggugguuccgcauggaagggccaucgcucaacggauaaaagcuaccccggggauaacaggcuuaucucccccaagaguccacaucgacggggagguuuggcaccucgaugucggcucaucgcauccuggggcuguagucggucccaaggguugggcuguucgcccauuaaagcgguacgcgagcuggguucagaacgucgugagacaguucggucccuauccgucgcgggcgcaggaaauuugagaggagcuguccuuaguacgagaggaccgggauggacgcaccgcugguguaccaguuguucugccaagggcaucgcuggguagcuaugugcggacgggauaagugcugaaagcaucuaagcaugaagccccccucaagaugagauuucccauuccgcaaggaaguaagaucccugaaagaugaucagguugauaggucugagguggaaguguggcgacacauggagcugacagauacuaaucgaucgaggacuuaacc <<<<<<<......<<<<<<<<<<<.....[[.(((<<<<<<<[[<<......<<<<<<..[..((.>>>.....<<<<<<<..<<<))..]..>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<<<<<<<<.........>>>>>>>.>>.>>....<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<......<<.....>>.....>>>>...(((....<<<<<<<<....>>>>>>>>......<<<<<<<<.<<<<<<<<<.<<<.....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>.>>>>..>>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.)))..............<<....>>....]].........<<<<....>>>>..................>>>>>>>>>>>.......<<<<..<<<<......>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<.<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>......>>>>>.>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<...<<<<<<<<<.....<<<...<<<<<<<<...<<.<<<<.....>>>>..>>...>>>>>>>>..>>.>.....>>>>.>>>>>..>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<......<.<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>.>..>>>>>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<..>>>>>>....>>>>>>..<<<<<<<.<<......<<<<<.<<....>>.>>>>>...>>.>>>>>>>........>>>>>>.......<<....<<<<<<.......>>>>>><<<<....<<<<<.<<<..<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<.<<<<<<......<<...<<<<....<<<<..<<<..<<<.<<<<<<<<...(((....>>>>>><<..<<<<<..<<<<<<<<<<<.<<.....>>>>>>>>>...>>>>..>>>>>...>><..<..>...>>>>>>...>>>...>>>>.........>>>>..>>..>>>>>>>>>>>>>>>.>>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<....<....>.....>>>>><<<<<....<<<<....>>>>...>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>..<<<<.<<<..<<<<<<<..<<<...<<...<<<<<<.<<....>>..>>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>...>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<<.<<<.<<<<<<<<<...............<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>......>>>>>>>>>.>>>....<<.<<<<<<.....>>>>>>>>.....>>>>>>>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<.<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>...>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.)))>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>>. (((((((......((((((((((.....(((..(((((((((((((......((((((..[..[[.))).....((((((...(((]]..]..)))......))))))...)))....(((....)))(((((((......))))))).(((((((((.........))))))).)).))....((((((.....(...[..)......))))).).........((....))...((((......((.]...)).....))))...((((...(((((((((..)))))))))....[.(((((((((((((((.((.(((...(.((((......)))))[[(...).(((.....]])))...)))...)).)))))))))))..)))))....((((((((..{......))))))))....].(((((}.[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((..((((..[...))))..)))).<.(.(........).).((((((....(((((((.(((((..(((...(((.....)))...)))...((....))..((((.....))))......))))).)))))))..((.(...((((((.....(((((((((..((((...((((((......))))))...)<)))...(((.(((((.......A))))))))....))))))))).(.((.......))...)..))))))......).))..((((((....(((((....))))).((((((((...(((((((((.....(((...((((((((...(((.(((.....))).).))...))))))))..)).).....)))).)))))..))))))).)...(((((((.((......)).)))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((...(............)..)))..........(......)....)))))...)))))))))).))...........]]].)...))))))))))...)))))))((((((()))))))....))))))(((((((...((......(((((.((....))])))))...))...))))).)).....))))))(......((....((((((.......))))))((((....(((...((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((.((((((......((...((((....((((..(((..(((.((((((((....{{....))))))((..(((((..(((((((((((.((.....)))))))))...))))..)))))...))(..(())...))))))...)))...))))(..).....))))..))..))))))))))))))).))).....((......))..))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.[..).....)))))(((((....((((....))))...)))))(...).......(((((((((.>.((.........))...(((((((.....(((....))).......))))))).]((((.(((..(((((((..(((...((...(((((..((....))...)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).[..(((((.....>].)))))..((((((((.(((.((......((((.((((((..(((((.(((((((((.(((.((.(.(((((..............((((...((......(((((.((....)).)))))...)).............)))).....))))).).)).)))....((.((((((.....)))))))).....)))))))))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..a.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..((((....))))....(((.(((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))....)))....))))))). Cryo-EM structure of a 70S Bacillus subtilis ribosome translating the ErmD leader peptide in complex with telithromycin; 23S ribosomal RNA 6ha1 B 112 3.1 RF00001 URS0000BC467F_224308 30126986 0003735 0005840 224308 ugguggcgauagcgaagaggucacacccguucccauaccgaacacggaaguuaagcucuucagcgccgaugguagucggggguuucccccugugagaguaggacgccgccaa <<<<<<<....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<.....<.<<.<<<<<...>>>>>.>>...>...>>..>>>>>>>. (((((((....((((((((.....((((((...(.....)...))))..))....)))))).)).((.......((.(((((...))))).)).......))..))))))). Cryo-EM structure of a 70S Bacillus subtilis ribosome translating the ErmD leader peptide in complex with telithromycin; 5S ribosomal RNA 6ha1 a 1533 3.1 RF00177,RF01959,RF01960 URS00007878BA_224308 30126986 0003735 0005840 224308 ggagaguuugauccuggcucaggacgaacgcuggcggcgugccuaauacaugcaagucgagcggacagaugggagcuugcucccugauguuagcggcggacgggugaguaacacguggguaaccugccuguaagacugggauaacuccgggaaaccggggcuaauaccggaugguuguuugaaccgcaugguucaaacauaaaagguggcuucggcuaccacuuacagauggacccgcggcgcauuagcuaguuggugagguaacggcucaccaaggcgacgaugcguagccgaccugagagggugaucggccacacugggacugagacacggcccagacuccuacgggaggcagcaguagggaaucuuccgcaauggacgaaagucugacggagcaacgccgcgugagugaugaagguuuucggaucguaaagcucuguuguuagggaagaacaagugccguucgaauagggcgguaccuugacgguaccuaaccagaaagccacggcuaacuacgugccagcagccgcgguaauacguagguggcaagcguuguccggaauuauugggcguaaagggcucgcaggcgguuucuuaagucugaugugaaagcccccggcucaaccggggagggucauuggaaacuggggaacuugagugcagaagaggagaguggaauuccacguguagcggugaaaugcguagagauguggaggaacaccaguggcgaaggcgacucucuggucuguaacugacgcugaggagcgaaagcguggggagcgaacaggauuagauacccugguaguccacgccguaaacgaugagugcuaaguguuaggggguuuccgccccuuagugcugcagcuaacgcauuaagcacuccgccuggggaguacggucgcaagacugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggucuugacauccucugacaauccuagagauaggacguccccuucgggggcagagugacagguggugcaugguugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuugaucuuaguugccagcauucaguugggcacucuaaggugacugccggugacaaaccggaggaagguggggaugacgucaaaucaucaugccccuuaugaccugggcuacacacgugcuacaauggacagaacaaagggcagcgaaaccgcgagguuaagccaaucccacaaaucuguucucaguucggaucgcagucugcaacucgacugcgugaagcuggaaucgcuaguaaucgcggaucagcaugccgcggugaauacguucccgggccuuguacacaccgcccgucacaccacgagaguuuguaacacccgaagucggugagguaaccuuuuaggagccagccgccgaaggugggacagaugauuggggugaagucguaacaagguagccguaucggaaggugcggcugg ...<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<<<<..<<<<<<..>>>>>>>..>>>>.>>>>>......<<........<<<<<<<..<<...<<<<<<<.<<<<.....<<<<<<....>>>>>>......>>>>.....<<<<<<<<<<<..>>>>>>>>>>>.....<<<<<<<..>>>>>>>.>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<<.......<.<<<<<<<<<.....>>>>>>>>>..>.......>>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<.......<<<<<<.....>>>>>>.....>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<......>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<....<<<<<....>>>>>....<<<<..>>>>.>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<......>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<..<<<<....<.<<<<..<<<..<<<...>>>.>>>.>>>>.>...>>>>..>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.. ...((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((.(.(((.((..)).))))..)))).)))))......(((.......(((((((..((...(((((((.((((.....((((((....))))))......)))).....((((((((((....)))))))))).....((((((....)))))).)))))))..))))))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....((((((...(.....((.((((.(.....).)))).)).....)....))))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.(((((((((.......((((((.....)))))).....)))))))..)))))))))..((((.((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))))..)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((......))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((.(..((((((((((......((........))..........(((((((..(...(((((((....(((((....)))))....(((....))).))))).))).((.(((...((((((.(....((((((.((....))....(((......)))...)))))).....((((.(((((((...((..((......))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..).))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((..((((....(.((((..(((..(((...))).))).)))).)...))))..))))))..))).))))..).))...)..)..(((((((((....)))))))))}. Cryo-EM structure of a 70S Bacillus subtilis ribosome translating the ErmD leader peptide in complex with telithromycin; 16S ribosomal RNA 6ha1 x 87 3.1 RF00005 URS00004630EA_562 30126986 0030533 0006412 562 gccgaggugguggaauugguagacacgcuaccuugaggugguagugcccaauagggcuuacggguucaagucccguccucgguacca <<<<<<<..<<<...........>>><<<<<<.......>>>>>><<<<....>>>>..<<<<<.......>>>>>>>>>>>>.... .((((((..(((......[....))).(((((.......))))).((.(.....)))..(((((..]....)))))))))))..... Cryo-EM structure of a 70S Bacillus subtilis ribosome translating the ErmD leader peptide in complex with telithromycin; P-tRNA 6ha8 A 2887 3.5 RF02540,RF02541,RF00002 URS00005906D8_224308 30126986 0003735 0005840 224308 guuaaguuagaaagggcgcacgguggaugccuuggcacuaggagccgaugaaggacgggacgaacaccgauaugcuucggggagcuguaagcaagcuuugauccggagauuuccgaauggggaaacccaccacucguaauggagugguauccauaucugaauucauaggauaugagaaggcagacccggggaacugaaacaucuaaguacccggaggaagagaaagcaaaugcgauucccugaguagcggcgagcgaaacgggaucagcccaaaccaagaggcuugccucuugggguuguaggacacucgaacgagguagaugaagaggucuggaaaggcccgccauaggagguaacagcccuguagucaaaacuucguucgaguggauccugaguacggcggaacacgugaaauuccgucggaauccgggaggaccaucucccaaggcuaaauacucccuagugaccgauagugaaccaguaccgugagggaaaggugaaaagcaccccggaaggggagugaaagagauccugaaaccgugugccuacaaguagucagagcccguuaacgggugauggcgugccuuuuguagaaugaaccggcgaguuacgaucucgugcaagguuaagcagaagaugcggagccgcagcgaaagcgagucugaauagggcgcaugaguacguggucguagacccgaaaccaggugaucuacccauguccagggugaaguucagguaacacugaauggaggcccgaacccacgcacguugaaaagugcggggaugagguguggguaggggugaaaugccaaucgaaccuggagauagcugguucucuccgaaauagcuuuagggcuagccucaagguaagagucuuggagguagagcacugauuggacuaggggccccuaccggguuaccgaauucagucaaacuccgaaugccaaugacuuauccuugggagucagacugcgagugauaagauccguagucgaaagggaaacagcccagaccgccagcuaaggucccaaaguauacguuaaguggaaaaggauguggaguugcuuagacaaccaggauguuggcuuagaagcagccaccauuuaaagagugcguaauagcucacuggucgagugacucugcgccgaaaauguaccggggcuaaacguaucaccgaagcugcggacuguucgaacagugguaggagagcguucuaagggcugugaagccagaccggaaggacugguggagcgcuuagaagugagaaugccgguaugaguagcgaaagaggggugagaauccccuccaccgaaugccuaagguuuccugaggaaggcucguccgcucaggguuagucgggaccuaagccgaggccgaaaggcguaggcgauggacaacagguugauauuccuguaccaccuccucaccauuugagcaauggggggacgcaggaggauaggguaagcgcgguauuggauauccgcguccaagcaguuaggcugggaaauaggcaaauccguuucccaaaggcugagcugugauggcgagcgcgaaguuccugauuccacacugccaagaaaagccucuagcgaggugagaggugcccguaccgcaaaccgacacagguaggcgaggagagaauccuaaggugaucgagagaacucucguuaaggaacucggcaaaaugaccccguaacuucgggagaaggggugcucuguuagggugcaagcccgagagagccgcagugaauaggcccaggcgacuguuuagcaaaaacacaggucucugcgaagccguaaggcgaaguauaggggcugacgccugcccggugcuggaagguuaagaggagcgcuuagcguaagcgaaggugcgaauugaagccccaguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgacccgcacgaaaggcgcaacgaucugggcacugucucaacgagagacucggugaaauuauaguaccugugaagaugcagguuacccgcgacaggacggaaagaccccguggagcuuuacugcagccugauauugaauguugguacagcuuguacaggauagguaggagccuuggaaaccggagcgccagcuucgguggaggcaucggugggauacuacccuggcuguauugaccuucuaacccgccgcccuuaucgggcggggagacagugucaggugggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguucccucagaaugguuggaaaucauucgcagaguguaaaggcacaagggagcuugacugcgagaccuacaagucgagcagggacgaaagucgggcuuagugauccggugguuccgcauggaagggccaucgcucaacggauaaaagcuaccccggggauaacaggcuuaucucccccaagaguccacaucgacggggagguuuggcaccucgaugucggcucaucgcauccuggggcuguagucggucccaaggguugggcuguucgcccauuaaagcgguacgcgagcuggguucagaacgucgugagacaguucggucccuauccgucgcgggcgcaggaaauuugagaggagcuguccuuaguacgagaggaccgggauggacgcaccgcugguguaccaguuguucugccaagggcaucgcuggguagcuaugugcggacgggauaagugcugaaagcaucuaagcaugaagccccccucaagaugagauuucccauuccgcaaggaaguaagaucccugaaagaugaucagguugauaggucugagguggaaguguggcgacacauggagcugacagauacuaaucgaucgaggacuuaacc <<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<..[..((.>>>.....<<<<<<<..<<.))..]...>>.....>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<<<<<<<<.........>>>>>>>.>>.>>....<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<......<<.....>>.....>>>>...(((....<<<<<<<<....>>>>>>>>......<<<<<<<<.<<<<<<<<<.<<<.....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>.>>>>..>>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<....>>>>..................>>>>>>>>>>>.......<<<<..<<<<......>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<.<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>......>>>>>.>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<...<<<<<<<<<.....<<<...<<<<<<<<...<<.<<<<.....>>>>..>>...>>>>>>>>..>>.>.....>>>>.>>>>>..>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<......<.<<<<<.<<...<<<<.......>>>>...>>.......<.<<......>>.>.>>>>>.>..>>>>>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<..>>>>>>....>>>>>>..<<<<<<<.<<......<<<<<.<<....>>.>>>>>...>>.>>>>>>>........>>>>>>.......<<....<<<<<<.......>>>>>><<<<....<<<<<.<<<..<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<.<<<<<<......<<...<<<<....<<<<..<<<..<<<.<<<<<<<<...(((....>>>>>><<..<<<<<..<<<<<<<<<<<.<<.....>>>>>>>>>...>>>>..>>>>>...>><..<..>...>>>>>>...>>>...>>>>.........>>>>..>>..>>>>>>>>>>>>>>>.>>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<....<<<<....>>>>...>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>..<<<<.<<<..<<<<<<<..<<<...<<...<<<<<<.<<....>>..>>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>...>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<<.<<<.<<<<<<<<<<<<............<<<...<<<......<<<<<<<<....>>>>>>>>...>>>.............>>>...>>>>>>>>>>>>.>>>....<<.<<<<<<.....>>>>>>>>.....>>>>>>>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.)))>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>>. (((((((......((((((((((.....(((..(((((((((((((......((((((..[..[[[)))...](((.(((...(((]]..]..)))......))).)).).)))....(((....)))(((((((......))))))).((((((((...........)))))).)).))....((((((.....(...[..)......))))).).........((....))...((((......((.]...)).....))))...((((...(((((((((..)))))))))....[.(((((((((((((((.((.(((...(.((((......)))))[[(...).(((.....]])))...)))...)).)))))))))))..)))))....((((((((..{......))))))))....].(((((}.[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((..((((..[...))))..)))).<.(.(........).).((((((....(((((((.(((((..(((...(((.....)))...)))...((....))..((((.....))))......))))).)))))))..((.(...((((((.....(((((((((..((((...((((((......))))))...)<)))...(((.(((((.......A))))))))....))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((...(((((((((.....(((...((((((((...(((.(((.....))).).))...))))))))..)).).....)))).)))))..))))))).)...(((((((.((......)).)))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((.(.....{.(((((.(((...((.........).)..))).....(...((......)).).)))))...).)))))))).))...........]]].)...))))))))))...)))))))((((((()))))))....))))))(((((((...((......(((((.((....))])))))...))...))))).)).....))))))(......((....((((((.......))))))((((....(((...((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((.((((((......((...((((....((((..(((..(((.((((((((....{{....))))))((..(((((..(((((((((((.((.....)))))))))...))))..)))))...))(..(())...))))))...)))...))))(..).....))))..))..))))))))))))))).))).....((......))..))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.[..).....)))))(((((....((((....))))...)))))(...).......(((((((((.>.((.........))...(((((((.....(((....))).......))))))).]((((.(((..(((((((..(((...((...((.((..((....))...)).))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).[..(((((.....>].)))))..((((((((.(((.((......((((.((((((..(((((.(((((((((.(((.((.(.((((((.............((((...((......((((..(......)..))))...)).............))))....)))))).).)).)))....((.((((((.....)))))))).....)))))))))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....((.((((.((..]]]]..)))))).)).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))..a.))..)))))))))))[...(((((((...((((..(.(((((.....(....)....))))).).(((((...((((...(((((((((((.}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..((((....))))....(((.(((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))....)))....))))))). Cryo-EM structure of the ABCF protein VmlR bound to the Bacillus subtilis ribosome; 23S rRNA 6ha8 B 112 3.5 RF00001 URS0000BC467F_224308 30126986 0003735 0005840 224308 ugguggcgauagcgaagaggucacacccguucccauaccgaacacggaaguuaagcucuucagcgccgaugguagucggggguuucccccugugagaguaggacgccgccaa <<<<<<<....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<.......<<.<<<<<...>>>>>.>>.......>>..>>>>>>>. (((((((....((((((((.....((((((...(.....)...))))..))....)))))).)).((.......((.(((((...))))).)).......))..))))))). Cryo-EM structure of the ABCF protein VmlR bound to the Bacillus subtilis ribosome; 5S rRNA 6ha8 a 1533 3.5 RF00177,RF01959,RF01960 URS00007878BA_224308 30126986 0003735 0005840 224308 ggagaguuugauccuggcucaggacgaacgcuggcggcgugccuaauacaugcaagucgagcggacagaugggagcuugcucccugauguuagcggcggacgggugaguaacacguggguaaccugccuguaagacugggauaacuccgggaaaccggggcuaauaccggaugguuguuugaaccgcaugguucaaacauaaaagguggcuucggcuaccacuuacagauggacccgcggcgcauuagcuaguuggugagguaacggcucaccaaggcgacgaugcguagccgaccugagagggugaucggccacacugggacugagacacggcccagacuccuacgggaggcagcaguagggaaucuuccgcaauggacgaaagucugacggagcaacgccgcgugagugaugaagguuuucggaucguaaagcucuguuguuagggaagaacaagugccguucgaauagggcgguaccuugacgguaccuaaccagaaagccacggcuaacuacgugccagcagccgcgguaauacguagguggcaagcguuguccggaauuauugggcguaaagggcucgcaggcgguuucuuaagucugaugugaaagcccccggcucaaccggggagggucauuggaaacuggggaacuugagugcagaagaggagaguggaauuccacguguagcggugaaaugcguagagauguggaggaacaccaguggcgaaggcgacucucuggucuguaacugacgcugaggagcgaaagcguggggagcgaacaggauuagauacccugguaguccacgccguaaacgaugagugcuaaguguuaggggguuuccgccccuuagugcugcagcuaacgcauuaagcacuccgccuggggaguacggucgcaagacugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggucuugacauccucugacaauccuagagauaggacguccccuucgggggcagagugacagguggugcaugguugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuugaucuuaguugccagcauucaguugggcacucuaaggugacugccggugacaaaccggaggaagguggggaugacgucaaaucaucaugccccuuaugaccugggcuacacacgugcuacaauggacagaacaaagggcagcgaaaccgcgagguuaagccaaucccacaaaucuguucucaguucggaucgcagucugcaacucgacugcgugaagcuggaaucgcuaguaaucgcggaucagcaugccgcggugaauacguucccgggccuuguacacaccgcccgucacaccacgagaguuuguaacacccgaagucggugagguaaccuuuuaggagccagccgccgaaggugggacagaugauuggggugaagucguaacaagguagccguaucggaaggugcggcugg ...<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<<<...<<<<<<..>>>>>>...>>>>.>>>>>......<<........<<<<<<<..<<...<<<<<<<.<<<<..<..<<<<<<....>>>>>>.....>>>>>.....<<<<<<<<<<<..>>>>>>>>>>>.....<<<<<.<..>.>>>>>.>>>>>>>..>>>>>>>>>.<<<....<<<...<<<<<<<.......>>>>>>>.>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<<.........<<<<<<<<<.....>>>>>>>>>..........>>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<.......<<<<<<.....>>>>>>.....>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<......>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<....<<<<<....>>>>>....<<<<..>>>>.>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<......>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<..<<<<....<.<<<<..<<<..<<<...>>>.>>>.>>>>.>...>>>>..>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.. ...((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((.(.((((((..)))))))..)))).)))))......(((.......(((((((..((...(((((((.((((.....((((((....))))))......)))).....((((((((((....)))))))))).....((((((....)))))).)))))))..))))))))).(((....(((...(((((((.......))))))).)))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......(((......))).....))))....((((((...(.....((.((((.(.....).)))).)).....)....))))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((....((.(((((((.((((.((((.......((((((.....)))))).....)))).))..)))))))))..((((.((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))))..)))..)))....))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((......))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((....(((((....)))))....(((....))).))))).))).((.((....((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..((......)))))...)))))))..(..(((((.....))))).....)..)))).....).).)))...))..))))....)))))))...)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((..((((....(.((((..(((..(((...))).))).)))).)...))))..))))))..))).))))..).))...)..)..(((((((((....)))))))))}. Cryo-EM structure of the ABCF protein VmlR bound to the Bacillus subtilis ribosome; 16S rRNA 6ha8 x 75 3.5 RF00005 URS0000D77907_562 30126986 0030533 0006412 562 gccgaggugguggaauugguagacacgcuaccuugaggugguaguuuacggguucaagucccguccucgguacca <<<<<<<..<<<...........>>><<<<<<.......>>>>>>..<<<<<.......>>>>>>>>>>>>.... (((((((..(((.....[.....))).(((((.......)))))...(((((..]....)))))))))))).... Cryo-EM structure of the ABCF protein VmlR bound to the Bacillus subtilis ribosome; P-tRNA(Leu) 6hak T 20 3.95 URS0000E60B74_11676 30902895 11676 aguggcggccgaacagggac .................... .................... Crystal structure of HIV-1 reverse transcriptase (RT) in complex with a double stranded RNA represents the RT transcription initiation complex prior to nucleotide incorporation; RNA (5'-R(P*AP*GP*UP*GP*GP*CP*GP*GP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*C)-3') 6hak P 17 3.95 URS0000E60B8B_9606 30902895 9606 ucccuguucggccgcca ................. ................. Crystal structure of HIV-1 reverse transcriptase (RT) in complex with a double stranded RNA represents the RT transcription initiation complex prior to nucleotide incorporation; RNA (5'-R(P*UP*CP*CP*CP*UP*GP*UP*UP*CP*GP*GP*CP*CP*GP*CP*CP*A)-3') 6hak E 20 3.95 URS0000E60B74_11676 30902895 11676 aguggcggccgaacagggac .................... .................... Crystal structure of HIV-1 reverse transcriptase (RT) in complex with a double stranded RNA represents the RT transcription initiation complex prior to nucleotide incorporation; RNA (5'-R(P*AP*GP*UP*GP*GP*CP*GP*GP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*C)-3') 6hak F 17 3.95 URS0000E60B8B_9606 30902895 9606 ucccuguucggccgcca ................. ................. Crystal structure of HIV-1 reverse transcriptase (RT) in complex with a double stranded RNA represents the RT transcription initiation complex prior to nucleotide incorporation; RNA (5'-R(P*UP*CP*CP*CP*UP*GP*UP*UP*CP*GP*GP*CP*CP*GP*CP*CP*A)-3') 6hbt A 18 1.66 URS0000BC4678_33072 30609994 33072 gguggggacgaccccanc <<<<<<<....>>>>>>> (((((((....))))))) The structure of the G. violaceus guanidine II riboswitch P2 stem-loop with arcaine; RNA (5'-R(*GP*GP*UP*GP*GP*GP*GP*AP*CP*GP*AP*CP*CP*CP*CP*AP*(CBV)P*C)-3') 6hcf A1 1732 3.9 RF01960,RF01959,RF00177 URS0000A7639A_9986 30293783 0003735 0005840 9986 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucguacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucagaucaaaaccaacccggucaggcggcuuuggugacucuagauaaccucgggccgaucgcacgcccggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcggccguccccugccucucggcgccccggggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgaccccggucggcguaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggugcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.{.((((>>>>><<<.<<<<<<.....<<..<......<<<.<<<...<....<<....<<..........>>...>>.>.......<<........<<<.<....<<....<<<<..........<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<<<....>>>>>>...>>>><<..<<<<<......((((.((.<<..<...>.>>....<......>..>>>>>......>>...<<<<..<<<.>>>.>>>>..>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>...<<....>>.....>>>>>>.........<<<....<<<.....>>>..>>>..>...>>.......<<<<<<<<<.<<......>>..>>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<..[[.....<.<<...<<<.<<....<<<.<<<..>>>.>>>...........<.<<<.>>>>.........<<<<<<.<.......<<...<.......>.<<<<.>>>>...>>......>.>>>..>>>..........<<.<<<<<<<......)).))))..>>>>>>>.>>......>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<........>>>>>>>>>.>..>>>...<<..]]>>...>>.....>>>...>.<<<......<<<......>>>....>>>..)))).}<<<<<.<<<<<<<...<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<......<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<.....<<<.<<<<......>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<.<<<..>>>..>>>>>>>>..>>>>..>.....<<<<<.....>>>>>........>>>.....>>.>>>.....>>>>>>>.......>>>>>...>>.>>>>.>>>.....<<.<<<................<<<.<<<<....>>>>.>>>..............>>>.>>............<<<<<..........>>>>>...........>>>>>.....<<<<<<<<.......>>>>>>>>......>....>>>>>>>>>>.>>.......<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<.<<<<<<<<<..>>>>>>>>>...>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>..........<<<<<<<<....>>>>>>>>.......... ...((((..[.[[[..))))(((.((..((...(.((..((.....(((.(((........((.....(..........)....))[.........((.......(.(.(....(.....(((.....(([...(.(....((.(((.....))).))......))......)).((((...(.((((....)))).)...))))((..(.(((..............................(......)..))).)......)).(].(((..(((.))).))).)...)))....)..).).).(((....(((....(((((((.........))))))))))......)))...(.(.((((....))))....).)))..((.(((..........))).)).(..(....)..)...)))))).).....(.(((...((((.]...))).))))).)...)).).....((((((((..((......).)..))))).)).)...(.((.................))......)..(.((([[......((((.....((..]])).......)))).))).)..))..)).)))..[......(.([[...(.(.((...(.(..(....(((.(((()))).)))..............(().)...........((((.(.(.......((..((.......)).(((.)))....))......).).)..)))........(..(.(.((.((...............)).)).).)..)....)....(((.((...(...((((..((..((..((((...((........))......))))..))..)).......((....))...))))..)...)..)))..).))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.(((........))))))))).)..)))...(...]].)...))...].))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((....(((.(.(((........(........)...........(((((.(....(((((........((..((........))..))......)))))...((.(((...(.((((((......(.(.(((....)))..(.((......)))....).)......(((...(...((.(..((((((....((..)).....))))))..).))..).....(((((.....)))))........)))....))).))).....).))))).....).)))))....).)).).))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....((((............)))).....)..)....))).....((.(..((.......))..).))......))...)))))))))).))..(.(..((.(...(((.((..(.((((.(((.(((..((((..(...(((((..(((((.(....).)))))....)))))...)..))))..))).))).)))))..)).)))....).))...)..)..(((.(((((....))))).)))}........ Structure of the rabbit 80S ribosome stalled on globin mRNA at the stop codon; 18S ribosomal RNA 6hcf 52 3634 3.9 RF02540,RF02543 URS0000D77958_9986 30293783 0003735 0005840 9986 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggaaauguggcguacggaagacccacuccccggcgccggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcgcgguccggccgugccggcggggcggaucucccgcucccgucggcgggggaccgccccccggccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggccccggcggggaagguggcccgggggccccggguguuacagccccgccccggcagcagcagcucgccgaaucccggggccgagggagcgagacccgugcgccgcgcucuccccccucgggggggccgggccaccccucccacggcgcgaccgcucucccacccggggggcggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccgggggagguucucucggggccacgcgucccccgcgagcgcacggggucggcggcgaugucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcuacgaaagccgccguggcgcaaugaaggugaaggccggcggcgcgccgccggccgaggugggaucccgaggccuuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcgaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccaaaguuucccucaggauagcuggcgcucuccgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcugguguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggaugguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgcuggcagucggcagagcgagaaagagaguggcgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucagccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcuggcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacaugagagguguagaauaagugggaggcccgggccgccggugaaauaccacuacucugaucguuuuuucacugacccggugaggcgggggggcgagccgggcucucgcuucuggcgccaagcgcccggccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauagcgccggagccucgguuggccucggauagccggucccccgccgggguccggugcggagagcccuucgucccgggaaacggggcggccggaaagggggccgcccucucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcugcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..[[[..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>>..<<<<<<<<<....<<<<<<<<..<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>...>>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>......((((..<<<<<<))))...]]]..................................<<....>>...............<<<......>>>..................................<<<<<<<<..<<<.<....<<<<<<<<.<<<.....<<<<<<<<<<.....<<<<<<.<<<<<.<<<<<<<.<<<<<<<.<.......>>>>>>>>>>>>>>>>>>>>>>>>...>>..>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<.<<<<<<<<<<.<<<<.........<..<<<<<<<......<<<<<<<...>>>>>>>.......>>>>>>>...>............>>>>...>>>>>>>>>>.....<<.......>>.........<....<<<<<..>>>>>....<.<<..<<<.<<<<<<<<<<<<<<<<<...<<.<<..>>>>.<<<<<<<...<<....>>...>>>>>>>>>>>.>>>>>>>>>>.>>>...>>>...<<....>>..>>.>................>.........>>.>>>>>....>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<.......>>>.....>>>...<<....>>...<<<<<<<<<<..>>>>>>>>>>..<<<<<...<<<..<<<...(((.[[.>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<..<<<<....>>>>..>.....>>>...<<<..<..<<........>>.>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<<....<<<....<<<..<.<<<..<<<<.<.........>.>>>>>>>.>..>>>...>>>....>>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>>>>>>.>>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<........<..<........<<.........>>...............<<......>>.....>.>....>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<..<<<....................]].)))............>>>.>>>>>....>>>>>>.<<<<<<<<<..<.......<<<<.<<<<....>>>>>>>>....>.>>>>>>>.>>.....>>>>>><<<....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>......<<<<<<...<<....<<<....>>>..........<..<<<<<.<<<...>>>.>>>>>.>......>>....>>>..<<<<<........>>>>>..<<<<....<<<.....<<<<<<<....>>>>>>>...<<<....>>>......<<<<......<<<<<<<<<<<<<<<<<<<<<<...{{{...>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>.>.>>>>>>>>>>>>............>>>>................>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<.>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<....<<<<<....>>>>.>...>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>...>>>....<<<<..........>>>>.....[[[[..{{{.{{......[[[[.{..[[[..<<<<..<<<<<<<<......<<.<.<<<.<<<<..........<<<<<..<<<<..>>>>............>>>>>.>>>>.>>.>>..>>.......<<<<<.....<<<<..<<.<<.......>>>>..............<<<<<<<<<..>>>>>>>>>..>>>>..>>>>>.....>>>>>>>>...>>>>....<<.....>>...<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))]......((((((..(((..>>>>>>.)))))))))..........]]]....}]]]].......<<..<<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.........<<<.<.<<<...<...<<<<<......>>>>>.....>.<<<.........>>>......>>>...>...>>>.......<<<<<<<....>>>.>>>>....}}..}}}.]]]]......<<<<<<....<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<.}}}..>>>>..>>.>>...>>>>...>>>><<<<....<<<<.............>>>>....>>>>.>>>.....>>>>>>.<<<<<<<..<<<.....<<<........<<<<<<..<<<<.>>>>>.>>>>>.......>>>...<<<..<<<<....<<<<<<<<<........>>>>>>.>>>...>>>>..>>>...............>>>..>.>>>>>>.<<<<<.<.............>....<<.<<<<<<<.<<.....<<<<.<..<<<<<.>>>>>..>>>>>....>>....>>>>.>>>.>>..>>>>>.. ..........................(.((......(...[..).......)).)...........((....))...((((......((.]...)).....))))...((((...(((..(((.(((((.........)))).).))....))))....(((((........(((((((...(.((((.(..({((.(......).)))....[[(...).(((....}]])))...)..))).))....))))))).......)))))..)....(((((((........)))))))......((((....[[[[))))...)))..................................((....))............(..((((....))))............).....................((((((((..(.(..(...((((((((.(((.....((((((((((.(..((((((..(((((.(((((((.((((..(.(.......))..)))))))))))))))).)))...))))))))))))))......))).))).)))))...(((..((((((((((((((.(((...(.(...(..(((((((...(..(((((.......))))).).....)))))))...)..........)))))...))))))))))).....((.....{.))...........(...(((....))).....(.((..(((.(((.(((((..(((((....((.((())))).(((((((....(....)....))))))).)).)))..)))))..)))...))).............).))............{.)..........)))...)))...).).)...)))))))).[((((........))))((((((..(.(.((((((.((((..(((..(((.........))..)..)))...((....))...(((..(.((.().)).)..)))..((..(.....(..((.}..[[[.[[[.))..).......).)).(..(..(((.(.((......)).))))...)..)....)))).)))))).)...(.(...((((((.....((((((.((..((((.....(((((....))))).....).)))...(((..((.(..........))).)))....)).)))))).(.(.........)...)..))))))......).).)..(((((....(.(((....))).).(..((((((...(((.(((((((.....(((.....((...((((..(((...............)))))).)..))...)).).....)))))...((((.((((.(......))))).))))....)))))))))).)..)...((((.(((((.....))))).))))....(((......)))...(((((((...((([[........(((((......(..........(((.(((.((((((...............(...((.........))...).......(...(........).).........)))))).))))))...........]].)....)))))..)))...)))))))((.(((.(((........}.........].]].]]]............)))))).))....)))))....(((.(((..(.......(((...(((....)))..))).....)))).)))........))))))((.....((.....((((((.......)))))).((.......(....(....(.((((...((.....)).)))).)......(((.((...((....(((....)))...........(.((((.............))))).......))....))...(((((........)))))..((......(((.....((.((((....)))).))...((......)).......(((.(....(((.(.(.(((((.((((((((.....{...)))))....(((((.((((...(......(((.....))).......).))))..))))).....(((.((((....).))).))))))..).)))).)..))))(...)......)))).................)))...)).)))...).....((......))...)..((((.....))))...))....(.((.....((((((..((.......(.......(((((....(.[..).....)))))((.(((((((.(.....).)..)))))).))(...).......((((((.((...((.........))....((((((....((((.....))))......))))))..].(((.(.(..((((((.(..(((.....((((....)))).....))))))))..))).)(.((...........)).)....................(((((.......)))))..........)))....))..)))))).)...))..))))))..)).)))....))....((((......]...)))).....((((..(((.((......((((.(.......((((..((((.(((......(..(...(.((((..........(((((..((((()))))............))))).)))).)...)...).......((.((.....((((..(..............)..............(((((.((....)).)))))..))))..)).)).....))).))))...))))..(((......[)).)((((............]..))))([((.....(((((.(.(((.((.......)).)))...).((]..[[[))....)))))...(.(((.(((((....{..)))).)))))((......)).))]]].......((((((..(.(..]]]]...).)))))))....)}...........))))).......((......(((((.................))))).......).)........((((.((((....(...(((((......))))).....).(((.(.....).))).......)))..)...))).).....(..((((....))).)..)....))..))).))))......((((.(.(...((....(((.(......(....).....).)))..((((....((((....((.((..(((}...)))....)).))...))))...)))).((.....((((.............)))).....))..))....)..))))).(((((....((((....(...........((((...(((...)))..))))..........)...(((..(((.....((.(.((((........)))).)..))....)))..)))..............)))).....))))).(((......................((.(((((((.(......((((.(..(((((.)))))..))))).....)....)))).))).))....))).. Structure of the rabbit 80S ribosome stalled on globin mRNA at the stop codon; 28S ribosomal RNA 6hcf 72 120 3.9 RF00001 URS000002B0D5_9986 30293783 0003735 0005840 9986 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu ....<.<<.....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<......<.<<..<<....>>.>>.>.....>>>>>>>.>>.>...... ......(((....((((((((.....(..(((...(....)...)))....)....)))))).))((((((......((..(..((....)).)..)).....)))))))))........ Structure of the rabbit 80S ribosome stalled on globin mRNA at the stop codon; 5S ribosomal RNA 6hcf 82 151 3.9 RF00002 URS00004B2C76_9986 30293783 0003735 0005840 9986 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcagguugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<.<<.....>>>.....(.<<<......>>........>>>..)...>>>....<<<..>>><<<<<<<<.......>>>>>>>>.................... .........................................(((((..[[......)).......(((......]]........)))......)))....((....))(((((((.........))))))).................... Structure of the rabbit 80S ribosome stalled on globin mRNA at the stop codon; 5.8S ribosomal RNA 6hcf 23 76 3.9 RF00005 URS0000868530_9986 30293783 0030533 9986 gucuccguaguguagcgguuaucacguucgccuaacacgcgaaagguccucgguucgaaaccgggcggaaacacca <<.<<<<..<<<..........>>>.<<.<<.......>>..>>....<<<<<.......>>>>>>>>>.>>.... ((.((((..(((.....[....))).(..((.......))..).....(.(((..]....))).))))).)).... Structure of the rabbit 80S ribosome stalled on globin mRNA at the stop codon; P-site tRNA 6hcf w3 23 3.9 30293783 9986 aaaaucaaaguuugagcucaaaa ....................... ....................... Structure of the rabbit 80S ribosome stalled on globin mRNA at the stop codon; mRNA 6hcj 51 3635 3.8 RF02540,RF02543 URS0000D77913_9986 30293783 0003735 0005840 9986 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggaaauguggcguacggaagacccacuccccggcgccggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcgcgguccggccgugccggcggggcggaucucccgcucccgucggcgggggaccgccccccggccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggccccggcggggaagguggcccgggggccccggguguuacagccccgccccggcagcagcagcucgccgaaucccggggccgagggagcgagacccgugcgccgcgcucuccccccucgggggggccgggccaccccucccacggcgcgaccgcucucccacccggggggcggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccgggggagguucucucggggccacgcgucccccgcgagcgcacggggucggcggcgaugucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcuacgaaagccgccguggcgcaaugaaggugaaggccggcggcgcgccgccggccgaggugggaucccgaggccuuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcgaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccaaaguuucccucaggauagcuggcgcucuccgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcugguguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggaugguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgcuggcagucggcagagcgagaaagagaguggcgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucagccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcuggcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacaugagagguguagaauaagugggaggcccgggccgccggugaaauaccacuacucugaucguuuuuucacugacccggugaggcgggggggcgagccgggcucucgcuucuggcgccaagcgcccggccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauagcgccggagccucgguuggccucggauagccggucccccgcccgggguccggugcggagagcccuucgucccgggaaacggggcggccggaaagggggccgcccucucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcugcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<......>..<<<<<<.....<<.....>>....>>>>>>..<<<..<.<<<...<<<<<<<<<<<...>>>>>>>.>>>>.....>>>.>..<<<.<<<<<....<<<..<<<..<<<<<<<<....<<<<......>>>>.............<<<.......>>>...>.>>>>>>>...>>>..>>>...>>>>.>>>>.......<<<<<<<........>>>>>>>......<<<<..(((((.>>>>...>>>..................................<<....>>...............<<<......>>>..................................<<<<<<<<..<<..<....<<<<<<<<.........<<<<<<<<<<....<<<<<<<.<<....<<<<<<<.<<<<<<<<<......>>>>>>>>>>>>>>>>...>>>>>>...>>>.>>>>>>>>>>..........>>>.>>>>>...<<<<<<<.<<<<<<<<<<.<<<<.........<..<<<<<<.......<<<<.<<<.>>>.>>>>........>>>>>>...>............>>>>...>>>>>>>>>>.....<<.......>>.............<<<<<<..>>>>>>...<.<<.<<<<.<<<<<<<...<<<<<<....<..<<...>>>.<<<<<<<...<<....>>...>>>>>>>.>>.>>>>...>>>>.>>>...>.>>>...........>>.>..........................>>.>>>>>....>.>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<.......>>>.....>>>...<<....>>...<<<<<<<<<<..>>>>>>>>>>..<<<<<...<<<..<<........[...>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<...<<.......<<.<.....>>>........>>....<<<..<..<<........>>.>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<<....<<<....<<<...<<<<..<<<.<<.........>.>>>>>>>.>..>>>...>>>....>>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>>>>>>.>>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<.(((.......<<<<<.....<<..........<<<.<<<..<<<.....................<<.........>>...............<<......>>.............>>>..>>>>>>..........))).>>...>>>>>...>>...>>>>>>><<<<<..<<<.....................]................>>>.>>>>>....>>>>>>..<<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>.>......>>>>>><<<....<<.....<<<<<<.......>>>>>>.<<......<<.<..<<...<<<<<<...<<.....>>.>>>>>>....(.<<<<<<...<<....<<<....>>>.............<<<<<.<<<...>>>.>>>>>........>>....>>>...<<<<........>>>>..)<<<<....<<<......<<<<<......>>>>>....<<<....>>>......<<<<<<<...<<<<<<<<<<<<<<<<<<<<<<<..[[[..>>>>>>.....<<<..<<<<.<<<<.....<<<.....>>>.....>>>>>>>>...>>>......<<<<<<<.......>>>>>>>>>>>.>.>>>>>>>>>>>>.........>>>>>>>................>>>.>>>>.>>>..>>.....<<......>>.>.>>.<<<<.....>>>>...>>....<<<<.....<<<<<<..<<...............<<<<<...............>>>>><<.<<<<<<<<<<<.>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>..<.<..<<<..<<<<<.....<<<......<<<....>>>......>>>..>>>..>>>>><..<<.........>>...>.......<...........<<<<<.......>>>>>.....>.....>..>..>>.>>>>>>>.....>>..>>>>>>..>>>>>>...>>>....<<<<<........>>>>>.....<<<<..<<<.<<......<<<<....<<<..<<<<..<<<<<<<<..<<<.<<<<...<.<<<<..........<<<<<...<<<..>>>.............>>>>>.>>>>.>...>.>>.>>>>...<<<<<.....<<<<.................................<<<<<.<<..>>.>>>>>...>>>>..>>>>>.....>>>>>>>>...>>>>....<<.....>>...<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<.<<<<<<.......>>>>.>>>>.<<<....>>>.>>)))]......<<<<<<..<<<...))))).>>>>>>>>>..........>>>.....>>>>.......<<..<<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.........<<<.<.<<<...<...<<<<<......>>>>>.....>.<<<.........>>>......>>>...>...>>>.......<<<<<<<....>>>.>>>>....>>..>>>.>>>>......<.<<<<....<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<..<.<<<.]]]..>>>....>.>>...>>>>...>>>><<<.....<<<<.............>>>>.....>>>.>>>.....>>>>.>.<<<<<<<..<<<.....<<.........<<<<<....<<<..>>>...>>>>>........>>...<<<..<<<<....<<<.<<<<<........>>>>>..>>>...>>>>..>>>...............>>>..>>.>>>>>.<<<<<.<.............>....<<.<<<<<<<.<<.....<<<<.<..<<<<<.>>>>>..>>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...(((.......((.]...))......)))...((((...(((..(((((((((((.....)))))).))))....))))....(((...(((.....(..(((...((((((((..(.(((.(.....)))).....).......(((.......)))...).)))))))....)).).)....)))...)))..)....((((((.(.......)))))))......(((...[.[[[[.)))...)))...................................(....)................(((......)))..................................((((.(.(..(((.((...((((((((.........((.(((((((....(((...(.((..(..(.((((.((.(((((...()...))))).))))).))..).)))......))).))))))).))..........))).)))))...(.(..(((.((.(((((((.(((...(........((((((.......((((.(((.))).))))........))))))...............))))...)))))).))).......(......{)........(.....(((((....)))))...(.(.......(((.(.(..(((((((.......(.().)...(((((((....(....)....))))))).)).)))))...))..))).....................))...................).....)))...).)...)))))...).).)))).[((((........)))).((.((....((((.(((..(((..(((...((((.....)))).....)))...((....))...((..((.(((..))).))..))..(((((........(.........[[[..).........))))).((((..(.(.((((......)))))..).)).))....)))..))).))))..((.(...((((((.....((((.(.((..((((......((........))......)<)))...(((..((.((........)))).)))....))..))))).(.((.......))...)..))))))......).))..((((((....(..((....))..).(.((..(((...((...(((..((.....(.....((....((((..((.((...........)).))))).)...))...)......).).))...(((((((((.........)))))))))....)..)))))..))..)...((((.((.((.....)).)).))))....(((......)))...(((((((...(..[[[...(.(.(((((......(..........(((.(((...((.....................((.........))...........(...((......)).)...........))...))))))..........]]].)....)))))))..)...)))))))((.((..(((........}.........].]]................))).)).))....)))))).((((((((.(.(.......(((..((((....)))).)))....)).)))))).)).....).))).((.....((.....(.((((.......)))).).(((.....((.(..((.....((((....(.....)..))))......[.(((.((...(.....(((....))).............((((.((((...)))).)))).........)....))...(((.(........).))).]((((....(((.(...(..((........))..)..((((....))).......(((.(....(((.(.(.((.((..((.((((...{{{...)))).....(((((.((((.((((.....(((.....))).....))))))))..))))).....(((.(((.......))).)))))...).).)).)..))))..........).)))....).........)..))).)))).)))..)).....((......)).).))..(((.....)))...)))....((((.....(((((((.(........(.......(((((....(....).....)))))((.((.((((((((.)))))..))).)).))............(((((((((.>...(........).....((((.(....((((.....))))......).)))).....(..(.(..(...((.(...((.....((((....))).)....)).))).....).))...(...........).......................((((.........))))...........).....)).))))))).)....).)))))))..))))))....))....(.(((.....]..))).)....((((...(((.((.......((....(.((..(((((.(.(((((((.(((.(.((...(.((((..........(..((..((((()))))............))..).)))).)...))...))))...(.(((.....((((.....(.......)...................((((...(..)...))))...))))..)).))....)))))).))..)))))..(.(......[)..)((.(............]..).))(.((...((.((.(.(...((((.......))).)....).((...[[[))....).))..))(.(((.(((((....{..)))).)))))(((....))).))]]].......((.(.(..(((..]]].]].)))).).))....)}....)).).....))........((.(....(((((...((.......))...))))).....).).)........(.((.((((.(..(...(((((......))))).....).(((.(.....).))).....).)))..)...))..).....(((.(((....)))..)))....))..)))..)))).....(((..(....(.(....(((((......(....).....)))))..((((....((((....((..(.((((}}}.))))...)..))...))))...))))..(......(..(............).)......)...).).....)..))).((((((...((((....(((.........((((...(.((..).))..))))........)))....((..(((.....((...(.((........)).)....))....)))..))...............))))...).))))).(.(((....(.......).......((..((.((..((.....((((.(..(..(...)..)..)))))....)).....))..))..))..)).)).. Structure of the rabbit 80S ribosome on globin mRNA in the rotated state with A/P and P/E tRNAs; 28S ribosomal RNA 6hcj 71 120 3.8 RF00001 URS000002B0D5_9986 30293783 0003735 0005840 9986 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu .<<<<<.......<<<<<<<......<<<<<..............>>>..>>.....>>>>>.>><<<<<<<......<.<<..<......>.>>.>.....>>>>>>>...>>>>>... ..(...(.......(((((((.....(..((....(....)....))....)....)))))).).((((((.......(.((..((....)).))..).....)))))).)....).... Structure of the rabbit 80S ribosome on globin mRNA in the rotated state with A/P and P/E tRNAs; 5S ribosomal RNA 6hcj 81 151 3.8 RF00002 URS00004B2C76_9986 30293783 0003735 0005840 9986 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcagguugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<.<<.((.....>>......<.<<<......))........>>>..>...>>>....<<<..>>><<<<<<<<.......>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]]........)))..)...)))....(......)((((((((.......)))))))).................... Structure of the rabbit 80S ribosome on globin mRNA in the rotated state with A/P and P/E tRNAs; 5.8S ribosomal RNA 6hcj A2 1740 3.8 RF01960,RF01959,RF00177 URS0000D7790F_9986 30293783 0003735 0005840 9986 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucguacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucagaucaaaaccaacccggucaggcggcuuuggugacucuagauaaccucgggccgaucgcacgcccggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcgggcggccguccguccccugccucucggcgccccggggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgaccccggucggcguaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggugcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<...((((>>>>><<<.<<<<<<.....<<.........<<<..<<........<.....<<..........>>....>.........<<........<<<.<....<<....<<.<..........<<.....<<..<.......>..>>......>>.........<<<<...<<<<<......>>>>>...>>>><<...<<<<......((((.....<..<...>..>....<......>..>>>>.......>>...<<<<.<<<<.>>>>>>>>..>..>>...>>..>.>>>.<<<....<<<.....<<<<<<.........>>>>>>.>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<.<.........>>>.>>...<<....>>.....>>.>>>.........<<<....<<<.....>>>..>>>......>>.......<<<<<<<<..<<<....>>>...>>>>>.>>>......<<..<...........>..>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>.>>>.........<.<.......<.<<...<<<.<<....<<<.<<<<<.<..>.>>>>>.>>>....<......<.<.....>>....>....<<<<<<.<........<...<.......>..<<<.>>.>...>.......>.>>>..>>>..........<<.<<<<<<<.........))))..>>>>>>>.>>......>>....<<<<<<......<<<<...<..<<<<<<<<...<<<......>>>......>>>>>>>.>.>........<<....>>...>>>>.....>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<....>>...>>.....>>>.>.>.<<<......<.<......>.>....>>>..))))...<<<<.<<<<<<...<<..<<<<...<<<.<<<<<<......<<........>>..........<<<<<......<<<<<........<...<<........>>...>......>>>>>...<..<<...<<.<<<.<.....<<<.<<<<......>>....<<......>>....>>.>>>....<<<...<...<<<<..<<<<<<<..<<<..>>>...>>>>>>>..>>>>..>.....<<<<<.....>>>>>........>>>.....>..>>>.....>>.>>.>.......>>>>>...>>.>>>>.>>>.....<<.<<<................<<<.<<<<....>>>>.>>>..............>>>.>>.............<<<<..........>>>>.............>>>>.....<<<<<<<<.......>>>>>>>>......>>....>>>>>>>>>.>........<<.<..<<<<.......<<<<<<<<.<<<..<<...<<...<<<<<.<<<<<<<<<..>>>>>>>>>...>>>>>...>>...>>..>>>.>>>>>>>>......>>>>...>.>>..........<<<<<<<<....>>>>>>>>.......... ...((((..[.[[[..))))(((.((..((.....((..((.....(((...(........((....(............)...))..........(........(((...(..((......(......([...(......((.(.(.....).).)).......)......)..((((...((((........))))...)))).(....(((........{.....(..........)....(......)..)))........)...](((...((...))..)))....).....)))...))).((......((....(((((((.........)))))))))........)).....(.((((....))))....)...)..((.((............)).)).(..(....)..)...)..))).).....(.(((...((.(.....).).))))).)...)).......((..((.(..((......))...).))...))....(.((..(...........)..))......)..((((([[......((((.....((..]])).......)))).)))))..))..)).)))..[......(.([[.....(.((...(((..(....(((..((..(.().)..))..)))...(...........().........)....(((((.(...........(.........)....................).)))..)).........(.((.(((.(.(..........}....).).))).)).)....)....(((.((...(...((((..((..((((((.....((........))........))))))..))........(....)....))))..)...)..)))..))))...).))....(((((.....(.....((.........)).....)..)))))......{...(((.(..(((..(.((((((.(((((....))))))))))).)..)))....(..]]).....)...].))).).)..((.......(((....))).....))....]]]..].((...(.((((..((..(((((..(((.(..((.......((........))..........(..((......(((..........(..................)........)))...((.(((.....(((..(........((((......))..(.((......)))...))........(((...(...(.((..((((((((...(..)....))))))))..)).)..).....(((((.....)))))........)))....)...))).......))))).......))..)....).)..).))).....((.((.........(.......(((.((((....)))).)))....)..........)).))..............(((..........))).............))))).....((((((.(.......).))))))......))...))).))..)).....(.(..((.....(((.......((.....(.(((..((.(.((...((((...(..(((((..)))))..).....))))...))..)))..))).).....))......)))......))...)..)..(((((((((....)))))))))}........ Structure of the rabbit 80S ribosome on globin mRNA in the rotated state with A/P and P/E tRNAs; 18S ribosomal RNA 6hcj q3 74 3.8 RF00005 URS000080E2D5_9986 30293783 0030533 0006412 9986 gcccggauagcucaggguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca ..<<<....<<<........>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>..>.>>..... .(((.(...((.(...[..).))..((((.......))))......(.(((..]....))).)..))))..... Structure of the rabbit 80S ribosome on globin mRNA in the rotated state with A/P and P/E tRNAs; A/P RNA 6hcj v3 22 3.8 30293783 9986 aaaaucgguguggcccuucucu ...................... ...................... Structure of the rabbit 80S ribosome on globin mRNA in the rotated state with A/P and P/E tRNAs; mRNA 6hcj 33 75 3.8 RF00005 URS0000326EAC_9986 30293783 0030533 0006412 9986 agcagaguggcgcagcggaagcgugcugggcccauaacccagaggucgauggaucgaaaccauccucugcuacca <<<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((....[..)))).((((.........)))).....(((((..]....)))))))))))).... Structure of the rabbit 80S ribosome on globin mRNA in the rotated state with A/P and P/E tRNAs; P/E tRNA 6hcm A1 1732 6.8 RF01960,RF01959,RF00177 URS0000A7639A_9986 30293783 0003735 0005840 9986 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucguacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucagaucaaaaccaacccggucaggcggcuuuggugacucuagauaaccucgggccgaucgcacgcccggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcggccguccccugccucucggcgccccggggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgaccccggucggcguaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggugcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.{.((((>>>>><<<.<<<<<<.....<<..<......<<<.<<<...<....<<....<<..........>>...>>.>.......<<........<<<.<....<<....<<<<..........<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<<<....>>>>>>...>>>><<..<<<<<......((((.((.<<..<...>.>>....<......>..>>>>>......>>...<<<<..<<<.>>>.>>>>..>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>...<<....>>.....>>>>>>.........<<<....<<<.....>>>..>>>..>...>>.......<<<<<<<<<.<<......>>..>>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<..[[.....<.<<...<<<.<<....<<<.<<<..>>>.>>>...........<.<<<.>>>>.........<<<<<<.<.......<<...<.......>.<<<<.>>>>...>>......>.>>>..>>>..........<<.<<<<<<<......)).))))..>>>>>>>.>>......>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<........>>>>>>>>>.>..>>>...<<..]]>>...>>.....>>>...>.<<<......<<<......>>>....>>>..)))).}<<<<<.<<<<<<<...<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<......<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<.....<<<.<<<<......>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<.<<<..>>>..>>>>>>>>..>>>>..>.....<<<<<.....>>>>>........>>>.....>>.>>>.....>>>>>>>.......>>>>>...>>.>>>>.>>>.....<<.<<<................<<<.<<<<....>>>>.>>>..............>>>.>>............<<<<<..........>>>>>...........>>>>>.....<<<<<<<<.......>>>>>>>>......>....>>>>>>>>>>.>>.......<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<.<<<<<<<<<..>>>>>>>>>...>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>..........<<<<<<<<....>>>>>>>>.......... ...((((..[.[[[..))))(((.((..((...(.((..((.....(((.(((........((.....(..........)....))[.........((.......(.(.(....(.....(((.....(([...(.(....((.(((.....))).))......))......)).((((...(.((((....)))).)...))))((..(.(((..............................(......)..))).)......)).(].(((..(((.))).))).)...)))....)..).).).(((....(((....(((((((.........))))))))))......)))...(.(.((((....))))....).)))..((.(((..........))).)).(..(....)..)...)))))).).....(.(((...((((.]...))).))))).)...)).).....((((((((..((......).)..))))).)).)...(.((.................))......)..(.((([[......((((.....((..]])).......)))).))).)..))..)).)))..[......(.([[...(.(.((...(.(..(....(((.(((()))).)))..............(().)...........((((.(.(.......((..((.......)).(((.)))....))......).).)..)))........(..(.(.((.((...............)).)).).)..)....)....(((.((...(...((((..((..((..((((...((........))......))))..))..)).......((....))...))))..)...)..)))..).))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.(((........))))))))).)..)))...(...]].)...))...].))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((....(((.(.(((........(........)...........(((((.(....(((((........((..((........))..))......)))))...((.(((...(.((((((......(.(.(((....)))..(.((......)))....).)......(((...(...((.(..((((((....((..)).....))))))..).))..).....(((((.....)))))........)))....))).))).....).))))).....).)))))....).)).).))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....((((............)))).....)..)....))).....((.(..((.......))..).))......))...)))))))))).))..(.(..((.(...(((.((..(.((((.(((.(((..((((..(...(((((..(((((.(....).)))))....)))))...)..))))..))).))).)))))..)).)))....).))...)..)..(((.(((((....))))).)))}........ Structure of the rabbit collided di-ribosome (stalled monosome); 18S ribosomal RNA 6hcm 52 3634 6.8 RF02540,RF02543 URS0000D77958_9986 30293783 0003735 0005840 9986 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggaaauguggcguacggaagacccacuccccggcgccggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcgcgguccggccgugccggcggggcggaucucccgcucccgucggcgggggaccgccccccggccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggccccggcggggaagguggcccgggggccccggguguuacagccccgccccggcagcagcagcucgccgaaucccggggccgagggagcgagacccgugcgccgcgcucuccccccucgggggggccgggccaccccucccacggcgcgaccgcucucccacccggggggcggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccgggggagguucucucggggccacgcgucccccgcgagcgcacggggucggcggcgaugucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcuacgaaagccgccguggcgcaaugaaggugaaggccggcggcgcgccgccggccgaggugggaucccgaggccuuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcgaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccaaaguuucccucaggauagcuggcgcucuccgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcugguguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggaugguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgcuggcagucggcagagcgagaaagagaguggcgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucagccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcuggcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacaugagagguguagaauaagugggaggcccgggccgccggugaaauaccacuacucugaucguuuuuucacugacccggugaggcgggggggcgagccgggcucucgcuucuggcgccaagcgcccggccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauagcgccggagccucgguuggccucggauagccggucccccgccgggguccggugcggagagcccuucgucccgggaaacggggcggccggaaagggggccgcccucucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcugcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..[[[..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>>..<<<<<<<<<....<<<<<<<<..<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>...>>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>......((((..<<<<<<))))...]]]..................................<<....>>...............<<<......>>>..................................<<<<<<<<..<<<.<....<<<<<<<<.<<<.....<<<<<<<<<<.....<<<<<<.<<<<<.<<<<<<<.<<<<<<<.<.......>>>>>>>>>>>>>>>>>>>>>>>>...>>..>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<.<<<<<<<<<<.<<<<.........<..<<<<<<<......<<<<<<<...>>>>>>>.......>>>>>>>...>............>>>>...>>>>>>>>>>.....<<.......>>.........<....<<<<<..>>>>>....<.<<..<<<.<<<<<<<<<<<<<<<<<...<<.<<..>>>>.<<<<<<<...<<....>>...>>>>>>>>>>>.>>>>>>>>>>.>>>...>>>...<<....>>..>>.>................>.........>>.>>>>>....>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<.......>>>.....>>>...<<....>>...<<<<<<<<<<..>>>>>>>>>>..<<<<<...<<<..<<<...(((.[[.>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<..<<<<....>>>>..>.....>>>...<<<..<..<<........>>.>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<<....<<<....<<<..<.<<<..<<<<.<.........>.>>>>>>>.>..>>>...>>>....>>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>>>>>>.>>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<........<..<........<<.........>>...............<<......>>.....>.>....>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<..<<<....................]].)))............>>>.>>>>>....>>>>>>.<<<<<<<<<..<.......<<<<.<<<<....>>>>>>>>....>.>>>>>>>.>>.....>>>>>><<<....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>......<<<<<<...<<....<<<....>>>..........<..<<<<<.<<<...>>>.>>>>>.>......>>....>>>..<<<<<........>>>>>..<<<<....<<<.....<<<<<<<....>>>>>>>...<<<....>>>......<<<<......<<<<<<<<<<<<<<<<<<<<<<...{{{...>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>.>.>>>>>>>>>>>>............>>>>................>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<.>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<....<<<<<....>>>>.>...>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>...>>>....<<<<..........>>>>.....[[[[..{{{.{{......[[[[.{..[[[..<<<<..<<<<<<<<......<<.<.<<<.<<<<..........<<<<<..<<<<..>>>>............>>>>>.>>>>.>>.>>..>>.......<<<<<.....<<<<..<<.<<.......>>>>..............<<<<<<<<<..>>>>>>>>>..>>>>..>>>>>.....>>>>>>>>...>>>>....<<.....>>...<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))]......((((((..(((..>>>>>>.)))))))))..........]]]....}]]]].......<<..<<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.........<<<.<.<<<...<...<<<<<......>>>>>.....>.<<<.........>>>......>>>...>...>>>.......<<<<<<<....>>>.>>>>....}}..}}}.]]]]......<<<<<<....<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<.}}}..>>>>..>>.>>...>>>>...>>>><<<<....<<<<.............>>>>....>>>>.>>>.....>>>>>>.<<<<<<<..<<<.....<<<........<<<<<<..<<<<.>>>>>.>>>>>.......>>>...<<<..<<<<....<<<<<<<<<........>>>>>>.>>>...>>>>..>>>...............>>>..>.>>>>>>.<<<<<.<.............>....<<.<<<<<<<.<<.....<<<<.<..<<<<<.>>>>>..>>>>>....>>....>>>>.>>>.>>..>>>>>.. ..........................(.((......(...[..).......)).)...........((....))...((((......((.]...)).....))))...((((...(((..(((.(((((.........)))).).))....))))....(((((........(((((((...(.((((.(..({((.(......).)))....[[(...).(((....}]])))...)..))).))....))))))).......)))))..)....(((((((........)))))))......((((....[[[[))))...)))..................................((....))............(..((((....))))............).....................((((((((..(.(..(...((((((((.(((.....((((((((((.(..((((((..(((((.(((((((.((((..(.(.......))..)))))))))))))))).)))...))))))))))))))......))).))).)))))...(((..((((((((((((((.(((...(.(...(..(((((((...(..(((((.......))))).).....)))))))...)..........)))))...))))))))))).....((.....{.))...........(...(((....))).....(.((..(((.(((.(((((..(((((....((.((())))).(((((((....(....)....))))))).)).)))..)))))..)))...))).............).))............{.)..........)))...)))...).).)...)))))))).[((((........))))((((((..(.(.((((((.((((..(((..(((.........))..)..)))...((....))...(((..(.((.().)).)..)))..((..(.....(..((.}..[[[.[[[.))..).......).)).(..(..(((.(.((......)).))))...)..)....)))).)))))).)...(.(...((((((.....((((((.((..((((.....(((((....))))).....).)))...(((..((.(..........))).)))....)).)))))).(.(.........)...)..))))))......).).)..(((((....(.(((....))).).(..((((((...(((.(((((((.....(((.....((...((((..(((...............)))))).)..))...)).).....)))))...((((.((((.(......))))).))))....)))))))))).)..)...((((.(((((.....))))).))))....(((......)))...(((((((...((([[........(((((......(..........(((.(((.((((((...............(...((.........))...).......(...(........).).........)))))).))))))...........]].)....)))))..)))...)))))))((.(((.(((........}.........].]].]]]............)))))).))....)))))....(((.(((..(.......(((...(((....)))..))).....)))).)))........))))))((.....((.....((((((.......)))))).((.......(....(....(.((((...((.....)).)))).)......(((.((...((....(((....)))...........(.((((.............))))).......))....))...(((((........)))))..((......(((.....((.((((....)))).))...((......)).......(((.(....(((.(.(.(((((.((((((((.....{...)))))....(((((.((((...(......(((.....))).......).))))..))))).....(((.((((....).))).))))))..).)))).)..))))(...)......)))).................)))...)).)))...).....((......))...)..((((.....))))...))....(.((.....((((((..((.......(.......(((((....(.[..).....)))))((.(((((((.(.....).)..)))))).))(...).......((((((.((...((.........))....((((((....((((.....))))......))))))..].(((.(.(..((((((.(..(((.....((((....)))).....))))))))..))).)(.((...........)).)....................(((((.......)))))..........)))....))..)))))).)...))..))))))..)).)))....))....((((......]...)))).....((((..(((.((......((((.(.......((((..((((.(((......(..(...(.((((..........(((((..((((()))))............))))).)))).)...)...).......((.((.....((((..(..............)..............(((((.((....)).)))))..))))..)).)).....))).))))...))))..(((......[)).)((((............]..))))([((.....(((((.(.(((.((.......)).)))...).((]..[[[))....)))))...(.(((.(((((....{..)))).)))))((......)).))]]].......((((((..(.(..]]]]...).)))))))....)}...........))))).......((......(((((.................))))).......).)........((((.((((....(...(((((......))))).....).(((.(.....).))).......)))..)...))).).....(..((((....))).)..)....))..))).))))......((((.(.(...((....(((.(......(....).....).)))..((((....((((....((.((..(((}...)))....)).))...))))...)))).((.....((((.............)))).....))..))....)..))))).(((((....((((....(...........((((...(((...)))..))))..........)...(((..(((.....((.(.((((........)))).)..))....)))..)))..............)))).....))))).(((......................((.(((((((.(......((((.(..(((((.)))))..))))).....)....)))).))).))....))).. Structure of the rabbit collided di-ribosome (stalled monosome); 28S ribosomal RNA 6hcm 72 120 6.8 RF00001 URS000002B0D5_9986 30293783 0003735 0005840 9986 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu ....<.<<.....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<......<.<<..<<....>>.>>.>.....>>>>>>>.>>.>...... ......(((....((((((((.....(..(((...(....)...)))....)....)))))).))((((((......((..(..((....)).)..)).....)))))))))........ Structure of the rabbit collided di-ribosome (stalled monosome); 5S ribosomal RNA 6hcm 82 151 6.8 RF00002 URS00004B2C76_9986 30293783 0003735 0005840 9986 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcagguugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<.<<.....>>>.....(.<<<......>>........>>>..)...>>>....<<<..>>><<<<<<<<.......>>>>>>>>.................... .........................................(((((..[[......)).......(((......]]........)))......)))....((....))(((((((.........))))))).................... Structure of the rabbit collided di-ribosome (stalled monosome); 5.8S ribosomal RNA 6hcm 23 76 6.8 RF00005 URS0000868530_9986 30293783 0030533 9986 gucuccguaguguagcgguuaucacguucgccuaacacgcgaaagguccucgguucgaaaccgggcggaaacacca <<.<<<<..<<<..........>>>.<<.<<.......>>..>>....<<<<<.......>>>>>>>>>.>>.... ((.((((..(((.....[....))).(..((.......))..).....(.(((..]....))).))))).)).... Structure of the rabbit collided di-ribosome (stalled monosome); P-site tRNA 6hcm w3 23 6.8 30293783 9986 aaaaucaaaguuugagcucaaaa ....................... ....................... Structure of the rabbit collided di-ribosome (stalled monosome); mRNA 6hcq 51 3635 6.5 RF02540,RF02543 URS0000D77913_9986 30293783 0003735 0005840 9986 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggaaauguggcguacggaagacccacuccccggcgccggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcgcgguccggccgugccggcggggcggaucucccgcucccgucggcgggggaccgccccccggccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggccccggcggggaagguggcccgggggccccggguguuacagccccgccccggcagcagcagcucgccgaaucccggggccgagggagcgagacccgugcgccgcgcucuccccccucgggggggccgggccaccccucccacggcgcgaccgcucucccacccggggggcggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccgggggagguucucucggggccacgcgucccccgcgagcgcacggggucggcggcgaugucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcuacgaaagccgccguggcgcaaugaaggugaaggccggcggcgcgccgccggccgaggugggaucccgaggccuuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcgaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccaaaguuucccucaggauagcuggcgcucuccgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcugguguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggaugguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgcuggcagucggcagagcgagaaagagaguggcgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucagccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcuggcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacaugagagguguagaauaagugggaggcccgggccgccggugaaauaccacuacucugaucguuuuuucacugacccggugaggcgggggggcgagccgggcucucgcuucuggcgccaagcgcccggccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauagcgccggagccucgguuggccucggauagccggucccccgcccgggguccggugcggagagcccuucgucccgggaaacggggcggccggaaagggggccgcccucucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcugcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<......>..<<<<<<.....<<.....>>....>>>>>>..<<<..<.<<<...<<<<<<<<<<<...>>>>>>>.>>>>.....>>>.>..<<<.<<<<<....<<<..<<<..<<<<<<<<....<<<<......>>>>.............<<<.......>>>...>.>>>>>>>...>>>..>>>...>>>>.>>>>.......<<<<<<<........>>>>>>>......<<<<..(((((.>>>>...>>>..................................<<....>>...............<<<......>>>..................................<<<<<<<<..<<..<....<<<<<<<<.........<<<<<<<<<<....<<<<<<<.<<....<<<<<<<.<<<<<<<<<......>>>>>>>>>>>>>>>>...>>>>>>...>>>.>>>>>>>>>>..........>>>.>>>>>...<<<<<<<.<<<<<<<<<<.<<<<.........<..<<<<<<.......<<<<.<<<.>>>.>>>>........>>>>>>...>............>>>>...>>>>>>>>>>.....<<.......>>.............<<<<<<..>>>>>>...<.<<.<<<<.<<<<<<<...<<<<<<....<..<<...>>>.<<<<<<<...<<....>>...>>>>>>>.>>.>>>>...>>>>.>>>...>.>>>...........>>.>..........................>>.>>>>>....>.>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<.......>>>.....>>>...<<....>>...<<<<<<<<<<..>>>>>>>>>>..<<<<<...<<<..<<........[...>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<...<<.......<<.<.....>>>........>>....<<<..<..<<........>>.>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<<....<<<....<<<...<<<<..<<<.<<.........>.>>>>>>>.>..>>>...>>>....>>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>>>>>>.>>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<.(((.......<<<<<.....<<..........<<<.<<<..<<<.....................<<.........>>...............<<......>>.............>>>..>>>>>>..........))).>>...>>>>>...>>...>>>>>>><<<<<..<<<.....................]................>>>.>>>>>....>>>>>>..<<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>.>......>>>>>><<<....<<.....<<<<<<.......>>>>>>.<<......<<.<..<<...<<<<<<...<<.....>>.>>>>>>....(.<<<<<<...<<....<<<....>>>.............<<<<<.<<<...>>>.>>>>>........>>....>>>...<<<<........>>>>..)<<<<....<<<......<<<<<......>>>>>....<<<....>>>......<<<<<<<...<<<<<<<<<<<<<<<<<<<<<<<..[[[..>>>>>>.....<<<..<<<<.<<<<.....<<<.....>>>.....>>>>>>>>...>>>......<<<<<<<.......>>>>>>>>>>>.>.>>>>>>>>>>>>.........>>>>>>>................>>>.>>>>.>>>..>>.....<<......>>.>.>>.<<<<.....>>>>...>>....<<<<.....<<<<<<..<<...............<<<<<...............>>>>><<.<<<<<<<<<<<.>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>..<.<..<<<..<<<<<.....<<<......<<<....>>>......>>>..>>>..>>>>><..<<.........>>...>.......<...........<<<<<.......>>>>>.....>.....>..>..>>.>>>>>>>.....>>..>>>>>>..>>>>>>...>>>....<<<<<........>>>>>.....<<<<..<<<.<<......<<<<....<<<..<<<<..<<<<<<<<..<<<.<<<<...<.<<<<..........<<<<<...<<<..>>>.............>>>>>.>>>>.>...>.>>.>>>>...<<<<<.....<<<<.................................<<<<<.<<..>>.>>>>>...>>>>..>>>>>.....>>>>>>>>...>>>>....<<.....>>...<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<.<<<<<<.......>>>>.>>>>.<<<....>>>.>>)))]......<<<<<<..<<<...))))).>>>>>>>>>..........>>>.....>>>>.......<<..<<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.........<<<.<.<<<...<...<<<<<......>>>>>.....>.<<<.........>>>......>>>...>...>>>.......<<<<<<<....>>>.>>>>....>>..>>>.>>>>......<.<<<<....<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<..<.<<<.]]]..>>>....>.>>...>>>>...>>>><<<.....<<<<.............>>>>.....>>>.>>>.....>>>>.>.<<<<<<<..<<<.....<<.........<<<<<....<<<..>>>...>>>>>........>>...<<<..<<<<....<<<.<<<<<........>>>>>..>>>...>>>>..>>>...............>>>..>>.>>>>>.<<<<<.<.............>....<<.<<<<<<<.<<.....<<<<.<..<<<<<.>>>>>..>>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...(((.......((.]...))......)))...((((...(((..(((((((((((.....)))))).))))....))))....(((...(((.....(..(((...((((((((..(.(((.(.....)))).....).......(((.......)))...).)))))))....)).).)....)))...)))..)....((((((.(.......)))))))......(((...[.[[[[.)))...)))...................................(....)................(((......)))..................................((((.(.(..(((.((...((((((((.........((.(((((((....(((...(.((..(..(.((((.((.(((((...()...))))).))))).))..).)))......))).))))))).))..........))).)))))...(.(..(((.((.(((((((.(((...(........((((((.......((((.(((.))).))))........))))))...............))))...)))))).))).......(......{)........(.....(((((....)))))...(.(.......(((.(.(..(((((((.......(.().)...(((((((....(....)....))))))).)).)))))...))..))).....................))...................).....)))...).)...)))))...).).)))).[((((........)))).((.((....((((.(((..(((..(((...((((.....)))).....)))...((....))...((..((.(((..))).))..))..(((((........(.........[[[..).........))))).((((..(.(.((((......)))))..).)).))....)))..))).))))..((.(...((((((.....((((.(.((..((((......((........))......)<)))...(((..((.((........)))).)))....))..))))).(.((.......))...)..))))))......).))..((((((....(..((....))..).(.((..(((...((...(((..((.....(.....((....((((..((.((...........)).))))).)...))...)......).).))...(((((((((.........)))))))))....)..)))))..))..)...((((.((.((.....)).)).))))....(((......)))...(((((((...(..[[[...(.(.(((((......(..........(((.(((...((.....................((.........))...........(...((......)).)...........))...))))))..........]]].)....)))))))..)...)))))))((.((..(((........}.........].]]................))).)).))....)))))).((((((((.(.(.......(((..((((....)))).)))....)).)))))).)).....).))).((.....((.....(.((((.......)))).).(((.....((.(..((.....((((....(.....)..))))......[.(((.((...(.....(((....))).............((((.((((...)))).)))).........)....))...(((.(........).))).]((((....(((.(...(..((........))..)..((((....))).......(((.(....(((.(.(.((.((..((.((((...{{{...)))).....(((((.((((.((((.....(((.....))).....))))))))..))))).....(((.(((.......))).)))))...).).)).)..))))..........).)))....).........)..))).)))).)))..)).....((......)).).))..(((.....)))...)))....((((.....(((((((.(........(.......(((((....(....).....)))))((.((.((((((((.)))))..))).)).))............(((((((((.>...(........).....((((.(....((((.....))))......).)))).....(..(.(..(...((.(...((.....((((....))).)....)).))).....).))...(...........).......................((((.........))))...........).....)).))))))).)....).)))))))..))))))....))....(.(((.....]..))).)....((((...(((.((.......((....(.((..(((((.(.(((((((.(((.(.((...(.((((..........(..((..((((()))))............))..).)))).)...))...))))...(.(((.....((((.....(.......)...................((((...(..)...))))...))))..)).))....)))))).))..)))))..(.(......[)..)((.(............]..).))(.((...((.((.(.(...((((.......))).)....).((...[[[))....).))..))(.(((.(((((....{..)))).)))))(((....))).))]]].......((.(.(..(((..]]].]].)))).).))....)}....)).).....))........((.(....(((((...((.......))...))))).....).).)........(.((.((((.(..(...(((((......))))).....).(((.(.....).))).....).)))..)...))..).....(((.(((....)))..)))....))..)))..)))).....(((..(....(.(....(((((......(....).....)))))..((((....((((....((..(.((((}}}.))))...)..))...))))...))))..(......(..(............).)......)...).).....)..))).((((((...((((....(((.........((((...(.((..).))..))))........)))....((..(((.....((...(.((........)).)....))....)))..))...............))))...).))))).(.(((....(.......).......((..((.((..((.....((((.(..(..(...)..)..)))))....)).....))..))..))..)).)).. Structure of the rabbit collided di-ribosome (collided monosome); 28S ribosomal RNA 6hcq 71 120 6.5 RF00001 URS000002B0D5_9986 30293783 0003735 0005840 9986 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu .<<<<<.......<<<<<<<......<<<<<..............>>>..>>.....>>>>>.>><<<<<<<......<.<<..<......>.>>.>.....>>>>>>>...>>>>>... ..(...(.......(((((((.....(..((....(....)....))....)....)))))).).((((((.......(.((..((....)).))..).....)))))).)....).... Structure of the rabbit collided di-ribosome (collided monosome); 5S ribosomal RNA 6hcq 81 151 6.5 RF00002 URS00004B2C76_9986 30293783 0003735 0005840 9986 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcagguugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<.<<.((.....>>......<.<<<......))........>>>..>...>>>....<<<..>>><<<<<<<<.......>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]]........)))..)...)))....(......)((((((((.......)))))))).................... Structure of the rabbit collided di-ribosome (collided monosome); 5.8S ribosomal RNA 6hcq A2 1740 6.5 RF01960,RF01959,RF00177 URS0000D7790F_9986 30293783 0003735 0005840 9986 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucguacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucagaucaaaaccaacccggucaggcggcuuuggugacucuagauaaccucgggccgaucgcacgcccggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcgggcggccguccguccccugccucucggcgccccggggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgaccccggucggcguaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggugcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<...((((>>>>><<<.<<<<<<.....<<.........<<<..<<........<.....<<..........>>....>.........<<........<<<.<....<<....<<.<..........<<.....<<..<.......>..>>......>>.........<<<<...<<<<<......>>>>>...>>>><<...<<<<......((((.....<..<...>..>....<......>..>>>>.......>>...<<<<.<<<<.>>>>>>>>..>..>>...>>..>.>>>.<<<....<<<.....<<<<<<.........>>>>>>.>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<.<.........>>>.>>...<<....>>.....>>.>>>.........<<<....<<<.....>>>..>>>......>>.......<<<<<<<<..<<<....>>>...>>>>>.>>>......<<..<...........>..>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>.>>>.........<.<.......<.<<...<<<.<<....<<<.<<<<<.<..>.>>>>>.>>>....<......<.<.....>>....>....<<<<<<.<........<...<.......>..<<<.>>.>...>.......>.>>>..>>>..........<<.<<<<<<<.........))))..>>>>>>>.>>......>>....<<<<<<......<<<<...<..<<<<<<<<...<<<......>>>......>>>>>>>.>.>........<<....>>...>>>>.....>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<....>>...>>.....>>>.>.>.<<<......<.<......>.>....>>>..))))...<<<<.<<<<<<...<<..<<<<...<<<.<<<<<<......<<........>>..........<<<<<......<<<<<........<...<<........>>...>......>>>>>...<..<<...<<.<<<.<.....<<<.<<<<......>>....<<......>>....>>.>>>....<<<...<...<<<<..<<<<<<<..<<<..>>>...>>>>>>>..>>>>..>.....<<<<<.....>>>>>........>>>.....>..>>>.....>>.>>.>.......>>>>>...>>.>>>>.>>>.....<<.<<<................<<<.<<<<....>>>>.>>>..............>>>.>>.............<<<<..........>>>>.............>>>>.....<<<<<<<<.......>>>>>>>>......>>....>>>>>>>>>.>........<<.<..<<<<.......<<<<<<<<.<<<..<<...<<...<<<<<.<<<<<<<<<..>>>>>>>>>...>>>>>...>>...>>..>>>.>>>>>>>>......>>>>...>.>>..........<<<<<<<<....>>>>>>>>.......... ...((((..[.[[[..))))(((.((..((.....((..((.....(((...(........((....(............)...))..........(........(((...(..((......(......([...(......((.(.(.....).).)).......)......)..((((...((((........))))...)))).(....(((........{.....(..........)....(......)..)))........)...](((...((...))..)))....).....)))...))).((......((....(((((((.........)))))))))........)).....(.((((....))))....)...)..((.((............)).)).(..(....)..)...)..))).).....(.(((...((.(.....).).))))).)...)).......((..((.(..((......))...).))...))....(.((..(...........)..))......)..((((([[......((((.....((..]])).......)))).)))))..))..)).)))..[......(.([[.....(.((...(((..(....(((..((..(.().)..))..)))...(...........().........)....(((((.(...........(.........)....................).)))..)).........(.((.(((.(.(..........}....).).))).)).)....)....(((.((...(...((((..((..((((((.....((........))........))))))..))........(....)....))))..)...)..)))..))))...).))....(((((.....(.....((.........)).....)..)))))......{...(((.(..(((..(.((((((.(((((....))))))))))).)..)))....(..]]).....)...].))).).)..((.......(((....))).....))....]]]..].((...(.((((..((..(((((..(((.(..((.......((........))..........(..((......(((..........(..................)........)))...((.(((.....(((..(........((((......))..(.((......)))...))........(((...(...(.((..((((((((...(..)....))))))))..)).)..).....(((((.....)))))........)))....)...))).......))))).......))..)....).)..).))).....((.((.........(.......(((.((((....)))).)))....)..........)).))..............(((..........))).............))))).....((((((.(.......).))))))......))...))).))..)).....(.(..((.....(((.......((.....(.(((..((.(.((...((((...(..(((((..)))))..).....))))...))..)))..))).).....))......)))......))...)..)..(((((((((....)))))))))}........ Structure of the rabbit collided di-ribosome (collided monosome); 18S ribosomal RNA 6hcq q3 74 6.5 RF00005 URS000080E2D5_9986 30293783 0030533 0006412 9986 gcccggauagcucaggguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca ..<<<....<<<........>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>..>.>>..... .(((.(...((.(...[..).))..((((.......))))......(.(((..]....))).)..))))..... Structure of the rabbit collided di-ribosome (collided monosome); A/P tRNA 6hcq v3 22 6.5 30293783 9986 aaaaucgguguggcccuucucu ...................... ...................... Structure of the rabbit collided di-ribosome (collided monosome); mRNA 6hcq 33 75 6.5 RF00005 URS0000326EAC_9986 30293783 0030533 0006412 9986 agcagaguggcgcagcggaagcgugcugggcccauaacccagaggucgauggaucgaaaccauccucugcuacca <<<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((....[..)))).((((.........)))).....(((((..]....)))))))))))).... Structure of the rabbit collided di-ribosome (collided monosome); P/E tRNA 6hct A 19 3.091 URS0000D7793E_224325 30327333 224325 gccgaugaaugcaugaagc ................... ................... Crystal structure of Archeoglobus fulgidus L7Ae bound to its cognate UTR k-turn; RNA (5'-R(*GP*CP*CP*GP*AP*UP*GP*AP*AP*UP*GP*CP*AP*UP*GP*AP*AP*GP*C)-3') 6hct B 19 3.091 URS0000D7793E_224325 30327333 224325 gccgaugaaugcaugaagc ................... ................... Crystal structure of Archeoglobus fulgidus L7Ae bound to its cognate UTR k-turn; RNA (5'-R(*GP*CP*CP*GP*AP*UP*GP*AP*AP*UP*GP*CP*AP*UP*GP*AP*AP*GP*C)-3') 6hct E 11 3.091 URS0000D77940_224325 30327333 224325 gccgaugaaug ........... ........... Crystal structure of Archeoglobus fulgidus L7Ae bound to its cognate UTR k-turn; RNA (5'-R(*GP*CP*CP*GP*AP*UP*GP*AP*AP*UP*G)-3') 6hd7 1 3335 3.4 RF02540,RF02543 URS000061F377_4932 30559462 0003735 0005840 4932 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaugguguuuugugcccucugcuccuuguggguaggggaaucucgcauuucacugggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguagugagggccuuggucagacgcagcgggcgugcuuguggacugcuugguggggcuugcucugcuaggcggacuacuugcgugccuuguuguagacggccuuggucuugcuacaauuaacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauagagggcuaccuuuauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<........<<.<<<<<<...>>>>>>.>>........>....<<<<<<.<<<<<<<<<<<<<<<<<<<<<.....<<<<......>>>>.((......<<<.....))>>>....>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((.<<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<......<<<....<<<<.<<<.<<<<<.....>>>>>.>>>.....>>>>....>>>..<<<<<<<<<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>....>>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<......>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>>..<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>........>>>>>><<<....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<..<<........>.>.>>....>>....>>>..<<<<<........>>>>>))<<<<.<<<<<.<.....<<<....>>>...<...<<<<<<...<<<<.<<<<<<<<<<<<<<<<<<..{{{..>>>>>>....<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>.....<<<<<<<<....>>>>>>>>>>>>.>.>>>>>>>.>>>>.........>>>>>>...>......>.>..>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<<..............<<<<<.....<..>......>>>>><<.<<<<<<<<<<<.<<<<<<.<....<.<<<.....<.....<<<<<<<..<<<<.<<<<..<<<<<<<....>>>>>>>..>>>>.>>>>..>>>>>>>......>.....>>>..>..>.>>>>>>......>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.....<<....<<<<<....>>>.>>...>>..>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>....>>>.>>>>>>>..>>>>>>...>>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<<<<<<<<<....>>>>>>>.>>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..(((..>>>>>>>)))))))))..........]]]]..}}]]]].......<<..<..<<<<<<...<<.......>>...>>>>>>....>.>.>.......<.<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>..>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<<...<<<<<<<<<<}}}.>>>>>..>>>>>..>>>>>..>>>>>.<<<<...<<<<.............>>>>...>>>>.>>>>....>>>>>>>>......<<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>.><<<<<.<..<.......>..>.....<<<<<<<<<.<<<....<<<<.<..<<<<<......>>>>>..>>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................((((((.....(...[..)......))))).).........((....))...((((......((.]...)).....))))...((((.........(((.((.(((...))).)).))....)........((.(((.(((((.(.(((((((((((.(....{((((......)))).[[(...).(((....}]])))....).))))))..))))).).....)))))))).))...)....(((((((........))))))).....(((((..[[[[.[)))))..)))..................................((....))............(..((((....))))............).....................(((((.(((((......((.(...((.(.((.((.(((.....))).)).)).....).))...).))..((((((((((((.((((((((((.......(((.(((......((((((....)))))).......))).))).....))))).))))).))))........(((....)))....)))))))).....))))).))))).<((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((...((((....))))....))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((....((((((....))))))....).)))...(((..((.((........)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.(((.(..(.((((.....)))).).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.((.((.....)).)).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.(((((((((......{.(((((.(((...((.........))...))).....(...(........).).)))))....))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...((((((...((.....)).))))))....[[((..((...((....(((....)))........(..(.(........)..).)....))....))....((((........)))).]]((((..(((((.(...((((....)))...(.[.((((((...(.((.(((((((.((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......)))))))))))...))))))).)).)(...)....))))))...))....).))..))).))))..))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(........((((....(.[..).....)))).((.(((((((.(((.((((..((....(.((............((..(((..((.(.(.((.(.(..(.(....).)..).).)).).).))..)))..)).............))..)..))..))))......))).)..)))))).))(...).......(((((((((...((.........))....((((((....((((.....))))......))))))..].(((.(((..((((((.....((.....((((....)))).....))..))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.((.(((((..(((((((((((((.((......)).))).))))))))))....((((.....((((..((((........))))...........]...((((((....))))))..))))..))))......))))).))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.].]]]]))))))))))....)}....))))..)))))).......((.(...(((((....((.......))....)))))....).).).......(((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).))....(.(((((....))).)).)....))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)((((....((((....((((((((((}}..)))))..)))))...))))...)))).((((...((((.....}.......))))...)))).))))....))))))))......(((((((.(((.((....((.(........((((.((..).).)))).....))).......((((((...((.((.(..(((......)))..).)).)).)))))).............)).))).)))))).)(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Cryo-EM structure of the ribosome-NatA complex; Saccharomyces cerevisiae S288C 35S pre-ribosomal RNA (RDN37-1), miscRNA 6hd7 3 121 3.4 RF00001 URS000055688D_4932 30559462 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<.....<.....>..>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(.(((..((....)).))).).....))))))))))))))). Cryo-EM structure of the ribosome-NatA complex; 5S rRNA 6hd7 4 158 3.4 RF00002 URS00001BF64E_4932 30559462 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<(.....>>............).>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Cryo-EM structure of the ribosome-NatA complex; 5.8S rRNA 6hd7 A 76 3.4 RF00005 URS000042DDAB_4932 30559462 0030533 0006412 4932 gggucguuagcucaguugguagagcaguugacuuuuaaucaauuggucgcagguucgaauccugcacgacccacca <<<<<<<..<<<<........>>>><<<<<<.......>>>>>>....<<<<.........>>>>>>>>>>>.... (((.((...((((........))))((((((.......)))))).....(.((.......)).)..)).))).... Cryo-EM structure of the ribosome-NatA complex; tRNA 6hd7 B 77 3.4 RF00005 URS000009EE82_4932 30559462 0030533 0006412 4932 ggagcgguaguucagucgguuagaauaccugccugucacgcagggggucgcggguucgagucccguccguuccgcca <<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((.(((...(((.........)))..(((((.......)))))......((((.......)))).))).))).... Cryo-EM structure of the ribosome-NatA complex; P-site tRNA 6hhq 1 3149 3.1 RF02540,RF02543 URS000061F377_4932 30759226 0003735 0005840 4932 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........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<<.<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<......<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<....<....>....>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.........>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<<....>>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>.>>>>>..<<<<.....<<<<<<<.<<...............<<<<<...............>>>>><<.<<<<<<.<<<......>>>...>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<...<<.....<<<<....>>>>.....>>.>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<.<>..>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<..<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>..>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. 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Crystal structure of compound C45 bound to the yeast 80S ribosome; 25S ribosomal RNA 6hhq 3 121 3.1 RF00001 URS000055688D_4932 30759226 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of compound C45 bound to the yeast 80S ribosome; 5S ribosomal RNA 6hhq 4 158 3.1 RF00002 URS00001BF64E_4932 30759226 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of compound C45 bound to the yeast 80S ribosome; 5.8S ribosomal RNA 6hhq AR 3147 3.1 RF02540,RF02543 URS000061F377_4932 30759226 0003735 0005840 4932 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........................<<<<<<.....<<....>>......>>>>>.>...{.....<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<.<<<<<<.<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>.>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]....}.............................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<<...<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<......>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<...<<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>>.<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>...<...<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>...>......>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<...............>>>>><<.<<<<<<<<<<......>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<..<<<.....<<<<....>>>>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<.....>>>>>>>>>...<<<<<.....<<<<..<<............>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<.}}}..>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. 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Crystal structure of compound C45 bound to the yeast 80S ribosome; 25S ribosomal RNA 6hhq AS 121 3.1 RF00001 URS000055688D_4932 30759226 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<<............>>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of compound C45 bound to the yeast 80S ribosome; 5S ribosomal RNA 6hhq AT 158 3.1 RF00002 URS00001BF64E_4932 30759226 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of compound C45 bound to the yeast 80S ribosome; 5.8S ribosomal RNA 6hhq A 1781 3.1 RF01960,RF01959,RF00177 URS0000D77925_4932 30759226 0003735 0005840 4932 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucau ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[..................<.....<<.<<<.....>>>.>>......>.........<<<<<..<<....>>..>>>>>....((((((......<<<<<<<<<<......>>..............)))))).........<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<.<<....<..........>....>>..>>......<<..<...........>..>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..))))))]]]].........[[[{{.......{{...[[[.[[....<<<<<<.<<<<<....<..>....>>>>>.>>>>>>....<<<<<<...............................>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[...((((((((....>>>>>>>>.))))))))..]].....]]....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>.>.>>......<<<....>>>..>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<.......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<..<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>........>>>>....>>>.>>>.....>>>>>>>>....>.>>>>>....>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<.<<..................>>.>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>....... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[[[[[[[(((....))).....(......).)))))).)...).(.((((.(((.......))))))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(.(.(.((....(....)....)).)...))......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((((.....().....))))).))))))....(.((((...............................)))).)...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(....(.((.(((....]]]]]]]].))).)).)...).....))...(((..((.((...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)).))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...((.(((..(....................)..))).))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>...... Crystal structure of compound C45 bound to the yeast 80S ribosome; 18S ribosomal RNA 6hhq sR 1783 3.1 RF01960,RF01959,RF00177 URS00005F2C2D_4932 30759226 0003735 0005840 4932 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccucuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucacuggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[...............<.....<<.<<.......>>.>>......>.........<<<<<..<<....>>..>>>>>[...((((((......<<<<<<<<<<<<..>>>>..............)))))).....]...<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<<<<..............>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.{{....<<<<<<.<<<..<<<<...>>>>......>>>.>>>>>>....<<<<<<....<<..<<<<.......>>>>..>>....>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[[..((((((((....>>>>>>>>.)))))))).]]].....}}....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<<.....>.>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<......<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<<<<<<<.....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>.....>>.>>>...>.>>>>>>>.......>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<.<<<..<........>....>>>.>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((...............(.....((.(((.....))).))......).........(((((..((....))..)))))(.(.((((((......[[[[[[[...(....).......(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(((((.(.....(....).....).)).)))....(.(.(.(...........))..)......)..((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.((...((((...)))).......)).))))))....((((((....((..(((((.....)))))..))....))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(((..(.((((((.....]]]]]]].)))))).).))).....))...(((..((..(...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)..))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(..((........((.(((........))).))......))..)...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...(((((((........................)))))))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>........ Crystal structure of compound C45 bound to the yeast 80S ribosome; 18S ribosomal RNA 6hma A 2834 2.65 RF02540,RF02541,RF00002 URS00001C3329_1280 26464510 0003735 0005840 1280 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<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<<<<<<<<.........>>>>>>>.>>.>>....<<<<<......<<....>>.......>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..(((....<<<<<<<<<..>>>>>>>>>......<<<<<<<<<...<<<<.......<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>.>>>>>..>>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<......>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<.<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>.>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<.>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<...<<<<<<<<<.....<<<...<<<<<<<<...<<.........>>...>>>>>>>>..>>.>.....>>>>>.>>>>..>>>>>>>.>>..<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<.<<<<........<..>....>>>>.>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<...>>>>>>>....>>>>>><.<<<<<<<.<<......<<<<<.<<....>>.>>>>>...>>.>>>>>>>..>.....>>>>>><......<<....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<..........<<<...<<<<....<<<<...<<...<....<.<<<.....{...>>>.>.<....<<<<...<<<.<<<<<<..>>>>>>......>>>...>>>>.....>..........................>....>>...>>>>.........>>>>..>>>.....>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<.......>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<<.<..........>.>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<<...........>>>>>>...>>...>>>>>>>>..>>>>><<<<<.....>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<<.<<<<.<<<<<<<<<...............<<..<<.........<<<<<<....>>>>>>......>>............>>.....>.>>>>>>>>.>>>>....<<.<<<<<<.....>>>>>>>>.....>>>>>>>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.}..>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<....>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>. ((((((......((((((((((.....(((..((((((((.((((......((((((.[[..[[[)))...].((((((...(((]]..]].)))......))))))...)))....(((....)))(((((((......))))))).(((((((((.........))))))).)).))....(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...((((((((....))))))))....[.(((((((((...((((.......((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))).)))))..)))))....(((((((...{.......)))))))....].(((((}.[[[[)))))..)))......))..)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).......((((..((((..[...))))..)))).{.(.(........).).((((((..(.(((((((.(((((..(((...(((.....)))...)))...((....))..((((.....)))).....))))).)))))))..((.(...((((((.....((((((((((.((((...((((((.))))))...){)))...(((.(((((........))))))))..).))))))))).(.(((....[)))...).]))))))......).))).((((((....(.(((....))).)(.(((((((...(((((((((.....(((...(((.((((...((.........))...)))).)))..)).).....))))).))))..)))))))..)..((((((((((......))))))))))....(((......)))...((.(.(((...((([[[...(.((((((.....(.....((..((((.(((((.......(())...))))).)))).))...........]]].)...))))))))))...)))).))(((((((...)))))))....))))))(((((((((.((......(((((.((....))])))))...)).))))))).)).....))))))(......((....((((((.......))))))((((....(((...((...((((((...((.....)).))))))....[[((((..(.(.(((...(((....)))...)))..))....(((((........)))))]](((((((...........((...((((....(((((..((...(....(.(.......<.....).).......(((...(((.((((((()))))))......)))...))).................................)....))..)))))(..).....))))..))......)))))))))))..)).....((......))..))).(((.......)))..))))..((((....((((((((.((..(....(.......(((((....(.[..).....)))))(((((((.((.......).).)))))))(...).......(((((((((.}.(...........)...(((((((.....(((....))).......))))))).]((((..((..(((((((..(((...((...(((((.............)))))...))...))))))))..)))).(((((.....)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)..[..(((((.....}].)))))..((((((((.(((.((......((((.((((((..(((((.(((((((((.((((..(((((((................((..(.(.......(..((((....))))..)....).)............))......).))))))..)))).....(.((((((.....)))))))......)))))))))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.>..))))))..)))))...)))).)))))...(((....((((.............))))....))).))))..]....))))))).(((....)))....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))....)))))). Improved model derived from cryo-EM map of Staphylococcus aureus large ribosomal subunit; 23S ribosomal RNA 6hma B 115 2.65 RF00001 URS0000062A7E_1280 26464510 0003735 0005840 1280 ucuggugacuauagcaaggaggucacaccuguucccaugccgaacacagaaguuaagcuccuuagcgucgaugguagucgaacuuacguuccgcuagaguagaacguugccaggc <<<<<<<<<....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<......<<<.<<<<....>>>>.>>>......>>..>>>>>>>>>. .(((((.((....((((((((.....((((((...(.....)...))))..))....)))))).)).((.......((.((((....)))).)).......))..)).))))).. Improved model derived from cryo-EM map of Staphylococcus aureus large ribosomal subunit; 5S ribosomal RNA 6hmi A 11 NA URS0000BC466C_9606 31636429 9606 auacuuaccug ........... ........... Solution structure of the RNA duplex formed by the 5'-end of U1snRNA and the 5'-splice site of SMN2 exon7; RNA (5'-R(*AP*UP*AP*CP*(PSU)P*(PSU)P*AP*CP*CP*UP*G)-3') 6hmi B 11 NA URS0000BC4661_9606 31636429 9606 ggaguaagucu ........... ........... Solution structure of the RNA duplex formed by the 5'-end of U1snRNA and the 5'-splice site of SMN2 exon7; RNA (5'-R(*GP*GP*AP*GP*UP*AP*AP*GP*UP*CP*U)-3') 6hmo A 11 NA URS0000BC466C_9606 31636429 9606 auacuuaccug ........... ........... Solution structure of the RNA duplex formed by the 5'-end of U1snRNA and the 5'-splice site of SMN2 exon7 in complex with the SMN-C5 splicing modifier; RNA (5'-R(*AP*UP*AP*CP*(PSU)P*(PSU)P*AP*CP*CP*UP*G)-3') 6hmo B 11 NA URS0000BC4661_9606 31636429 9606 ggaguaagucu ........... ........... Solution structure of the RNA duplex formed by the 5'-end of U1snRNA and the 5'-splice site of SMN2 exon7 in complex with the SMN-C5 splicing modifier; RNA (5'-R(*GP*GP*AP*GP*UP*AP*AP*GP*UP*CP*U)-3') 6hrm 1 4450 2.96 RF00177,RF02540,RF02541,RF01959,RF01960 URS00021ED93C_562 30518861 0003735 0005840 562 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........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((.....((((((......))))))....))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..........)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((....((((....))))..)))).)).))))))..((((......((((....)))).....))))........((...(....(.(.(.............).).).....)....))..........((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((...(...((((((......))))))..............)....))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((.............))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...((((((......(((..((...(((....)))...))....)))......))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((..........(.(....((...(((((.(((.....((..(.((((((((((....)))))))))......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((.(((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))))))).)))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).<.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((..........................)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((.............{....((......(.............)..........(...(........).).))..............)).))...........]]].)...))))))))))...)))))))((((...(......)...))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((...(((...(((....)))...)))...)))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).[..(((((.....>].)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((((..(....(((..............(...(((.......(.(.(((....))).).)....))).............).....)).)...)..))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(.(((((....))).)).)....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))).(((((.....))))))....))..(((((.......)))))....))))))))..))....).).........)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... E. coli 70S d2d8 stapled ribosome; stapled 16S-23S rRNA,stapled 16S-23S rRNA,stapled 16S-23S rRNA,stapled 16S-23S rRNA 6hrm 3 120 2.96 RF00001 URS0000049E57_562 30518861 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. .(((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))).. E. coli 70S d2d8 stapled ribosome; 5S ribosomal RNA 6htq A 2887 4.5 RF02540,RF02541,RF00002 URS000197CF79_224308 32937119 0003735 0005840 224308 guuaaguuagaaagggcgcacgguggaugccuuggcacuaggagccgaugaaggacgggacgaacaccgauaugcuucggggagcuguaagcaagcuuugauccggagauuuccgaauggggaaacccaccacucguaauggagugguauccauaucugaauucauaggauaugagaaggcagacccggggaacugaaacaucuaaguacccggaggaagagaaagcaaaugcgauucccugaguagcggcgagcgaaacgggaucagcccaaaccaagaggcuugccucuugggguuguaggacacucgaacgagguagaugaagaggucuggaaaggcccgccauaggagguaacagcccuguagucaaaacuucguucgaguggauccugaguacggcggaacacgugaaauuccgucggaauccgggaggaccaucucccaaggcuaaauacucccuagugaccgauagugaaccaguaccgugagggaaaggugaaaagcaccccggaaggggagugaaagagauccugaaaccgugugccuacaaguagucagagcccguuaacgggugauggcgugccuuuuguagaaugaaccggcgaguuacgaucucgugcaagguuaagcagaagaugcggagccgcagcgaaagcgagucugaauagggcgcaugaguacguggucguagacccgaaaccaggugaucuacccauguccagggugaaguucagguaacacugaauggaggcccgaacccacgcacguugaaaagugcggggaugagguguggguaggggugaaaugccaaucgaaccuggagauagcugguucucuccgaaauagcuuuagggcuagccucaagguaagagucuuggagguagagcacugauuggacuaggggccccuaccggguuaccgaauucagucaaacuccgaaugccaaugacuuauccuugggagucagacugcgagugauaagauccguagucgaaagggaaacagcccagaccgccagcuaaggucccaaaguauacguuaaguggaaaaggauguggaguugcuuagacaaccaggauguuggcuuagaagcagccaccauuuaaagagugcguaauagcucacuggucgagugacucugcgccgaaaauguaccggggcuaaacguaucaccgaagcugcggacuguucgaacagugguaggagagcguucuaagggcugugaagccagaccggaaggacugguggagcgcuuagaagugagaaugccgguaugaguagcgaaagaggggugagaauccccuccaccgaaugccuaagguuuccugaggaaggcucguccgcucaggguuagucgggaccuaagccgaggccgaaaggcguaggcgauggacaacagguugauauuccuguaccaccuccucaccauuugagcaauggggggacgcaggaggauaggguaagcgcgguauuggauauccgcguccaagcaguuaggcugggaaauaggcaaauccguuucccaaaggcugagcugugauggcgagcgcgaaguuccugauuccacacugccaagaaaagccucuagcgaggugagaggugcccguaccgcaaaccgacacagguaggcgaggagagaauccuaaggugaucgagagaacucucguuaaggaacucggcaaaaugaccccguaacuucgggagaaggggugcucuguuagggugcaagcccgagagagccgcagugaauaggcccaggcgacuguuuagcaaaaacacaggucucugcgaagccguaaggcgaaguauaggggcugacgccugcccggugcuggaagguuaagaggagcgcuuagcguaagcgaaggugcgaauugaagccccaguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgacccgcacgaaaggcgcaacgaucugggcacugucucaacgagagacucggugaaauuauaguaccugugaagaugcagguuacccgcgacaggacggaaagaccccguggagcuuuacugcagccugauauugaauguugguacagcuuguacaggauagguaggagccuuggaaaccggagcgccagcuucgguggaggcaucggugggauacuacccuggcuguauugaccuucuaacccgccgcccuuaucgggcggggagacagugucaggugggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguucccucagaaugguuggaaaucauucgcagaguguaaaggcacaagggagcuugacugcgagaccuacaagucgagcagggacgaaagucgggcuuagugauccggugguuccgcauggaagggccaucgcucaacggauaaaagcuaccccggggauaacaggcuuaucucccccaagaguccacaucgacggggagguuuggcaccucgaugucggcucaucgcauccuggggcuguagucggucccaaggguugggcuguucgcccauuaaagcgguacgcgagcuggguucagaacgucgugagacaguucggucccuauccgucgcgggcgcaggaaauuugagaggagcuguccuuaguacgagaggaccgggauggacgcaccgcugguguaccaguuguucugccaagggcaucgcuggguagcuaugugcggacgggauaagugcugaaagcaucuaagcaugaagccccccucaagaugagauuucccauuccgcaaggaaguaagaucccugaaagaugaucagguugauaggucugagguggaaguguggcgacacauggagcugacagauacuaaucgaucgaggacuuaacc <<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<..[..((.>>>.....<<<<<<<..<<<))..]..>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<<<<<<<<.........>>>>>>>.>>.>>....<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<......<<.....>>.....>>>>...(((....<<<<<<<<....>>>>>>>>......<<<<<<<<..<<<<<<<<.<<<.....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>..>>>>..>>>>..........<<<.........>>>...........<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<......>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<.<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>......>>>>>.>>>>>>>..<<.<..<<<<<<<.....<<<<<<.<...<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>.....>.>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<...<<<<<<<<......<<<...<<<<<<<<...<<.<<<<.....>>>>..>>...>>>>>>>>..>>.>......>>>.>>>>>..>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<......<.<<<<<.<<...<<...........>>...>>.........<<......>>...>>>>>.>..>>>>>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<..>>>>>>....>>>>>><.<<<<<<<.<.......<<<<<.<<....>>.>>>>>....>.>>>>>>>..>.....>>>>>><......<.....<<<<<<.......>>>>>><<<<....<<<<<.<<<..<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<................>>>...>>....<<<<........>>>>.))<<<<..<<<<<<......<<...<<<<....<<.<<.<<<..<<<.<<<<<<<<...(((....>>>>>><<..<<<<<..<<<<<<<<<<<.<<.....>>>>>>>>>...>>>>..>>>>>...>><..<..>...>>>>>>...>>>...>>>>.........>>>>..>>..>>>>>>.>>>>>>>>.>>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>...<<<....<<<<<<<<..<<..............<<<<<...............>>>>><<<<<....<<<<....>>>>...>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<......................>>>>>>>..<<<<.<<<..<<<<<<<..<<<...<<...<<<<<<.<<....>>..>>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>...>>.>>>>>>>....>>..>>>>>>>>.>>>..>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<....<<<.<<<<<<<<<<..............<<....<<<......<<<<<<<<....>>>>>>>>...>>>..............>>.....>>>>>>>>>>.>>>....<<.<<<<<.......>>>>>>>........>>>>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<.<<<...<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>.......>>>..>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.)))>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<....>>>>....<<<<<<<<.........>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>>. (((((((......((((((((((.....(((..((((((((.((.(......((((((.....[[[)))...](((.(((...(((]].....)))......))).)).).)))....(((....)))(((((((......))))))).(((((((((.........))))))).)).).....(((..(.....(......).......).)).).........((....))...((((......((.....)).....))))...((((...(((((((((..)))))))))....[.((((((((.(((((((((.(((...(.((((......)))))[[(...).(((.....]])))...)))...))))))))).))))..))))).........(((..{......)).)........].(((((}.[[[[)))))..)))......))..)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((...((((..[...))))...)))...(.(........).).((((((....(((((((.(((((..((....(((.....)))....))...(......)..(((.......)))......))))).)))))))..((.(...(.((((.....((((((((((.((((...((((((......))))))...).)))...(((.(((.(.......<).))))))..).))))))))).(.(.........)...)..)))).)......).))..(((((.....(((((....)))))(((.(((((...(((((.(.(.....(((...((((((((...(((((.(.....).))).))...))))))))..)).).....).)..)))))..))))).).))..((((.((..(......)..)).))))....(((......)))...((((..((...((([[[.....((((((.....(.....((..((((((((((.....{.(((((.((....(............)...)).....(...((......)).).)))))...)))))))))).))...........]]].)...)))))).)))...)).))))((((((())))))).....)))))(((((((...((......(((((.((....))])))))...))...))))).)).....))))))(......((....((((((.......))))))((((....((....((..(.(((((...(.......).))))).....[[.(((.((...(((................)))...))...(((((........)))))]](((((.((((((......((...((((....((((..((...(((.((((((((....{{....))))))((..(((((..(((.(((((((.((.....)))))))))....)))..)))))...))(..(())...))))))....))...))))(..).....))))..))..))))))))))))))..))).....((......))...)).((((.....))))..))))..((((....((((((.(..........(.......(((((....(.[..).....)))))(((((....(((......)))...)))))(...).......(.(((((((...((.........))....(.(.((.....(........).......))..))..]((((...(..((...((..(.....((...(((((..((....))...)))))...)).....))).....)))..((((...........)))).........(..........(.((.........)).)..).......))))...)).))))).).)......).)))))).)))))).....)).[..((((.......]..))))..(.((((((.(((.((......((((.((((((..(((((.((((..(...(((.((.(.(((((...(......[...(.....(((......((((((((....))))))))...)))..........]....))....))))).).)).))).....(.((((((.....)))))))........)..))))..)))))..(((......[)))(((.((..........])).)))..((...(((((((.(.(((((.........)))))...).((.[.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((.(((.((..]]]]..))))).)))......}......))))..))))))......(((((.(.(((.((...((.......))...).))))...)))).).)........((.((.(((..((.((((((......))))))...)).(((((.....))))).....))).)..)...).).......(((((((....))).))))..>.))..))))))))).)[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...((.((((((((.}}.))))))..)).))...)))).)))))...(((.(..(.((.....}.......)).)...)))).))))..]....)))))))..((((....))))....(.(.((((.........))))....((((((((.(((....(((((....)))))...)))..))))).)))....).)....))))))). Stringent response control by a bifunctional RelA enzyme in the presence and absence of the ribosome; 23S ribosomal RNA 6htq B 112 4.5 RF00001 URS0000BC467F_224308 32937119 0003735 0005840 224308 ugguggcgauagcgaagaggucacacccguucccauaccgaacacggaaguuaagcucuucagcgccgaugguagucggggguuucccccugugagaguaggacgccgccaa <<<<<<<....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<.....<.<<.<<<<<...>>>>>.>>...>...>>..>>>>>>>. (((((((....((((((((.....((((((...(.....)...))))..))....)))))).)).((.......(..(((((...)))))..).......))..))))))). Stringent response control by a bifunctional RelA enzyme in the presence and absence of the ribosome; 5S ribosomal RNA 6htq a 1533 4.5 RF00177,RF01959,RF01960 URS000197CF6E_224308 32937119 0003735 0005840 224308 ggagaguuugauccuggcucaggacgaacgcuggcggcgugccuaauacaugcaagucgagcggacagaugggagcuugcucccugauguuagcggcggacgggugaguaacacguggguaaccugccuguaagacugggauaacuccgggaaaccggggcuaauaccggaugguuguuugaaccgcaugguucaaacauaaaagguggcuucggcuaccacuuacagauggacccgcggcgcauuagcuaguuggugagguaacggcucaccaaggcgacgaugcguagccgaccugagagggugaucggccacacugggacugagacacggcccagacuccuacgggaggcagcaguagggaaucuuccgcaauggacgaaagucugacggagcaacgccgcgugagugaugaagguuuucggaucguaaagcucuguuguuagggaagaacaagugccguucgaauagggcgguaccuugacgguaccuaaccagaaagccacggcuaacuacgugccagcagccgcgguaauacguagguggcaagcguuguccggaauuauugggcguaaagggcucgcaggcgguuucuuaagucugaugugaaagcccccggcucaaccggggagggucauuggaaacuggggaacuugagugcagaagaggagaguggaauuccacguguagcggugaaaugcguagagauguggaggaacaccaguggcgaaggcgacucucuggucuguaacugacgcugaggagcgaaagcguggggagcgaacaggauuagauacccugguaguccacgccguaaacgaugagugcuaaguguuaggggguuuccgccccuuagugcugcagcuaacgcauuaagcacuccgccuggggaguacggucgcaagacugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggucuugacauccucugacaauccuagagauaggacguccccuucgggggcagagugacagguggugcaugguugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuugaucuuaguugccagcauucaguugggcacucuaaggugacugccggugacaaaccggaggaagguggggaugacgucaaaucaucaugccccuuaugaccugggcuacacacgugcuacaauggacagaacaaagggcagcgaaaccgcgagguuaagccaaucccacaaaucuguucucaguucggaucgcagucugcaacucgacugcgugaagcuggaaucgcuaguaaucgcggaucagcaugccgcggugaauacguucccgggccuuguacacaccgcccgucacaccacgagaguuuguaacacccgaagucggugagguaaccuuuuaggagccagccgccgaaggugggacagaugauuggggugaagucguaacaagguagccguaucggaaggugcggcugg ...<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<<<...<<<<<<..>>>>>>...>>>>.>>>>>......<<........<<<<<<...<<...<<<<<<<.<<<<.....<<<<<<....>>>>>>......>>>>.....<<<<<<<<<<....>>>>>>>>>>.....<<<<<<....>>>>>>.>>>>>>>..>>.>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<.......<<<....>>>......>>>>....<<<<<<.......<.<<<<<<<<.......>>>>>>>>.>........>>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<.......<<<<<<.....>>>>>>.....>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<......>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<..<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<....<<<<<....>>>>>....<<<<..>>>>.>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<...<......>.>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>.....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<..<<<<....<.<<<<..<<<..<<<...>>>.>>>.>>>>.>...>>>>..>>>>>>..>>.>>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.. ...((((..[.[[[..))))..(((.(((((..(((((((((....(((.(((..(((..((..(.(.(.((((((..)))))))..).)..)))))......(((.......(((((((..((...(((((((.((((.....((((((....))))))......)))).....((((((((((....)))))))))).....((((((....)))))).)))))))..)))))))))..((....(((..((((((((.......)))))))))))......))...((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......(.((....)).).....))))....((((((...(.....((.((((((.....)))))).)).....)....))))))......((((([[[...(((((.....((.]]])).......))))))))))..))))))))...........((([[...(.((((...((..(((((((.((((((((((......((((((.....))))))...).)))))))..)))))))))..(((((((((...((((((((....((((((....(..........).......))))))....).......((....)).)))))))..))))).)))..).))...)))).....((.(.........((((.........))))......).)).......{....(((((..((((((((((((......))))))))))))...((..]])).....))))).)))).(((.......(((....))).....)))...]]].](.((..((((.((.((..(((....((((((((((......((........))..........(((((((..(...(((((((....(((((....)))))....(((....))).))))).))).((.(((...((((.(.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..((......)))))...)))))))..(..(((((.....))))).....)..)))).....).)..))...)).)))))....)))))))...)).)))))))).....(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....).......))).....(((((((.........)))))))......))...)).)))).))..).......((.(.((.(.(.(..((((....((((....(.((((..(((..(((...))).))).)))).)...))))....))))..)..).)))..).))............((.(((....))).))...}. Stringent response control by a bifunctional RelA enzyme in the presence and absence of the ribosome; 16S rRNA 6htq v 87 4.5 RF00005 URS00004630EA_224308 32937119 0030533 0006412 224308 gccgaggugguggaauugguagacacgcuaccuugaggugguagugcccaauagggcuuacggguucaagucccguccucgguacca <<<<<<<..<<<...........>>><<<<<<.......>>>>>><<<<....>>>>..<<<<<.......>>>>>>>>>>>>.... (((((((..(((...........))).(((((.......))))).((((....))))..(((((.......)))))))))))).... Stringent response control by a bifunctional RelA enzyme in the presence and absence of the ribosome; P-tRNA 6htq u 76 4.5 RF00005 URS000024E9F9_224308 32937119 0030533 0006412 224308 gcccggauagcucaguugguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((.(..(((..........)))((((((.......))))).)...((.((.......)).))).))))).... Stringent response control by a bifunctional RelA enzyme in the presence and absence of the ribosome; A/R-tRNA 6htq w 75 4.5 RF00005 URS0000287EC9_224308 32937119 0030533 0006412 224308 cccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... (((((...((((........)))).((((.........))))......((((.......))))..)))))..... Stringent response control by a bifunctional RelA enzyme in the presence and absence of the ribosome; E-tRNA 6htu D 19 2.888 URS0000E60BDB_9606 30456389 9606 gagugccagaagcugccuc ................... ................... Structure of hStau1 dsRBD3-4 in complex with ARF1 RNA; RNA (19-MER) 6htu F 19 2.888 URS0000E60B69_9606 30456389 9606 gaggcaguuucugguacuc ................... ................... Structure of hStau1 dsRBD3-4 in complex with ARF1 RNA; RNA (19-MER) 6hu6 A 19 1.904 URS0000E60BDB_9606 30456389 9606 gagugccagaagcugccuc ................... ................... Structure of ARF1 RNA; RNA (19-MER) 6hu6 E 19 1.904 URS0000E60B69_9606 30456389 9606 gaggcaguuucugguacuc ................... ................... Structure of ARF1 RNA; RNA (19-MER) 6hu6 B 10 1.904 URS0000E60BB8_9606 30456389 9606 gagugccaga .......... .......... Structure of ARF1 RNA; RNA (5'-R(*GP*AP*GP*UP*GP*CP*CP*AP*GP*A)-3') 6i0y A 2854 3.2 RF02540,RF02541 URS000080E25C_562 30413621 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauggaaguguggacgccagucugcauggcuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<.....>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>.>......>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.......................................>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((((((.)))).))...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..((((......))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((((.(.............................................).))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). TnaC-stalled ribosome complex with the titin I27 domain folding close to the ribosomal exit tunnel; 23S ribosomal RNA 6i0y B 118 3.2 RF00001 URS0000366A67_562 30413621 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))). TnaC-stalled ribosome complex with the titin I27 domain folding close to the ribosomal exit tunnel; 5S ribosomal RNA 6i0y V 77 3.2 RF00005 URS000034D020_562 30413621 0030533 0006412 562 cggcacguagcgcagccugguagcgcaccgucauggggugucgggggucggagguucaaauccucucgugccgacca <<<<<<<..<<<<.........>>>>.<<<.<<.....>>.>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((......[..)))).(((.(.......).))).....(((((..]....)))))))))))).... TnaC-stalled ribosome complex with the titin I27 domain folding close to the ribosomal exit tunnel; Proline tRNA 6i7o BQ 3127 5.3 RF02540,RF02543 URS000061F377_4932 30609991 0003735 0005840 4932 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguuaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[...........<<.<<<<<<...>>>>>>.>>.............<<<<<<<.<<<<<<<<<<<<<<<<<<<<.....<<<<......>>>>.(.......<<<......)>>>....>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<......<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<......>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<......>>>>>>>>>....>>>>>><..<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>...>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<..>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<<<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>.>.>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<...............>>>>><<.<<<<<<<<<<<..>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<...>>>>>>>...<<<<<.....<<<<..<<<..........>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>........<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>.....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<...<<<<<<<<<<<}}}.>>>>>..>>>>>>..>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>....<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((.(((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))).....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.(((((......(((((((((((((((((((((((.......(((((((......((((((....)))))).......))))))).....))))).))))))))))........(((....)))....)))))))).....))))).))))).<((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))..).))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...(.((((.....)))).).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.......(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((......)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((..((((((....((.....))..)))))....[[(((.((...((....(((....)))........((((....))))....))....))...(((((........)))))]]((((..(((((((...((((....)))...(.[[((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).))).))).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((..)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.....((.....((((....)))).....))..))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.((((((((..((((((.(..)))))))....((((.....((((..(((.(......).)))..........]]...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.............))))...)))).))))....))))))))...(((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).)))))).)(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. The structure of a di-ribosome (disome) as a unit for RQC and NGD quality control pathways recognition.; 25S ribosomal RNA 6i7o BR 121 5.3 RF00001 URS000055688D_4932 30609991 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). 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The structure of a di-ribosome (disome) as a unit for RQC and NGD quality control pathways recognition.; 18S ribosomal RNA 6i7o YQ 3127 5.3 RF02540,RF02543 URS000061F377_4932 30609991 0003735 0005840 4932 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........................<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[...........<<.<<<<<<...>>>>>>.>>.............<<<<<<.<<<<<<<<<<<<<<<<<<<<<.....<<<<......>>>>.(.......<<<......)>>>....>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<......<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<......>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.........>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<......<..........<<<.<<<<<<<<<........<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>....>>>>>>>>>>>>..........))).>....>>>>>>.>>>>..>>>>>>><<<<<<<<<......>>>>>>>>>....>>>>>><<<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>.>>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<....>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<..>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<....<<<<<....>>>>.>...>>>.>>>>..>>>>><<<<<.........>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{.[[[..<<<<<.<<<<<<<<..<<<<<<<...>>>>>>>...<<<<<.....<<<<..<<<<........>>>>...............<<<<<......>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]...}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.........<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.......<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<...<<<<<<<<<<<}}}.>>>>>..>>>>>>..>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>....<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<.<..<<<<........>>>>..>>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((.(((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))).....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.(((((......(((((((((((((((((((((((.......(((((((......((((((....)))))).......))))))).....))))).))))))))))........(((....)))....)))))))).....))))).))))).<((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))..).))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...(.((((.....)))).).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.......(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((......)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((..((((((....((.....))..)))))....[[(((.((...((....(((....)))........(((......)))....))....))...(((((........)))))]]((((..(((((.(...((((....)))...(.[[((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....).))..))).)))).))).))).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.((((((((((.(.)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.....((.....((((....)))).....))..))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.((((((((..((((((.(..)))))))...(((((.....((((..(((.(......).)))..........]]...((((((....))))))..))))..))))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(..(((((...((.......))...)))))....)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.............))))...)))).))))....))))))))...(((((((.(((.((....((.(........((((((.....)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).)))))).)(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. The structure of a di-ribosome (disome) as a unit for RQC and NGD quality control pathways recognition.; 25S ribosomal RNA 6i7o YR 121 5.3 RF00001 URS000055688D_4932 30609991 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<....<<<.<<..............>>....>>...>>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). The structure of a di-ribosome (disome) as a unit for RQC and NGD quality control pathways recognition.; 5S ribosomal RNA 6i7o YS 157 5.3 RF00002 URS00004A45D3_4932 30609991 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauu .........................................<<<<<<<<<....>>>>.....<.<<<......>>..............>>>..>...>>>....<<.....>><<<<<<<<<....>>>>>>>>>.................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....))))))))).................... The structure of a di-ribosome (disome) as a unit for RQC and NGD quality control pathways recognition.; 5.8S ribosomal RNA 6i7o n 76 5.3 RF00005 URS0000E60BDA_4932 30609991 0030533 0006412 4932 uuccucguggcccaauggucacggcgucuggcuacgaaccagaagauuccagguucaaguccuggcggggaagcca <<<<<<<..<<<..........>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..(((.....[....))).(((((.......))))).....(((((..]....)))))))))))).... The structure of a di-ribosome (disome) as a unit for RQC and NGD quality control pathways recognition.; P-site tRNA 6i7o m 75 5.3 RF00005 URS0000E60BA3_4932 30609991 0030533 0006412 4932 uccgauauagcguaacggcuaucacaucacgcuuucaccguggagaccgggguucgacuccccguaucggagcca <<<<<<<..<.<..........>.>.<<<<<.......>>>>>....<<<<<.......>>>>>>>>>>>>.... (((((((..(.(.....[....).).(((((.......)))))....(((((..]....)))))))))))).... The structure of a di-ribosome (disome) as a unit for RQC and NGD quality control pathways recognition.; E-site tRNA 6i7o nb 76 5.3 RF00005 URS00008FED3A_4932 30609991 0030533 0006412 4932 gcccggauagcucagucgguagagcaggggauuaggaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... ..(((((..((((........))))..((.(.......).))......((.((.......)).)))))))...... The structure of a di-ribosome (disome) as a unit for RQC and NGD quality control pathways recognition.; A/P hybrid tRNA 6i7o mb 77 5.3 RF00005 URS000041AF00_4932 30609991 0030533 0006412 4932 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... The structure of a di-ribosome (disome) as a unit for RQC and NGD quality control pathways recognition.; P/E hybrid tRNA 6i7o l 57 5.3 30609991 4932 uuuuuuuuuuuugacaaauuuuuuuuuuaauccuggauggaacgaccguuuuuuuuu ......................................................... ......................................................... The structure of a di-ribosome (disome) as a unit for RQC and NGD quality control pathways recognition.; mRNA 6i7v AA 1533 2.9 RF00177,RF01959,RF01960 URS000080E246_562 30359641 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<.<<<......>>>.>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<.....<<<<....>>>>................>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<..<<<<<<....<...<<<.....>>>.>.....>>>>>>.....<<<<<.....>>>>>.........>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((.(..((......))..)..)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((...(.....))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(..(.((((((((.......)))))))).)...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.((((..(.((((((((((......((((((.....))))))....))))))))..)))..))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((.(((......((........))..........(((((((..(...(((.(((.....(.(......).).......(....)...))).).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((.(...((..(((.....)))))....).)))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).).)))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Ribosomal protein paralogs bL31 and bL36; 16S ribosomal RNA 6i7v BA 1533 2.9 RF00177,RF01959,RF01960 URS000080E246_562 30359641 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggauca .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<......>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<...<<....>>.>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<.<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>.............>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<<..<<<.....>>>>>.....>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>..>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<...<<....>>..>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((.((.((........)).))..))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....))).....(((((..........)))))..)))))))..)).)))))))(((.....((..((((((((.......)))))))))).......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(..(.(.((((((.......)))))).).)...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((....((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..)))....))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..(((((.(.((......((........))........(.(((.(.(......(((..((..((((..........)))).............))..).))..((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((...((.....)).))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....).).))))..))..).))))).....(((((((.....(((..((....(.......)...))....))).....)))))))......(....((..(((........)))..))....).....))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Ribosomal protein paralogs bL31 and bL36; 16S ribosomal RNA 6i7v DA 2897 2.9 RF02540,RF02541 URS000080E25C_562 30359641 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<.....>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<.....................>>........<<........>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<......>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<..<<<............<<<<....<<......<<<<<<<<....>>>>>>>>...>>..............>>>.>..>>>..>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((((...))).))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((...(............)..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((((......))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((.((.((((.((.....)))))).))...))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((.(((..(((...........((.(....((......(((..............)))...))..............).))..)))..))).)))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).).....((.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..))....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Ribosomal protein paralogs bL31 and bL36; 23S ribosomal RNA 6i7v CA 2898 2.9 RF02540,RF02541 URS00004B0F34_562 30359641 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccuu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<.<<....(((.>>......<<<<<<<..<<.))).....>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<...>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<...........>>...>>.........<........>...>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<.<<....>>.>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>...<<<<........>>>>.))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>>....<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>.....<..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<....<.<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<..<<....>>...>>>>>..>....>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<..<<<.<<<<<.<<<<<<<<<<<.<<<............<<<<....<<......<<<<<<<<....>>>>>>>>...>>..............>>>>...>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>...>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>.. ((((((((......((((((((((.....(((..((..(((((((((.......(((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)).....(((....)))((((.((....)).)))).(((((((((.........))))))))).))...(..(((.....(......)......)).)..).........((....))...(((((.....((.....))....)))))...(((..((((.......((.(((((((((.(((...(((((......)))))[.(...).((.......].))...)))...))))))))).))....)))).........(((.(((..[......))).))).......((.((].[[[[)).))..)))......)).)))))...))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((.(..(((...((.....))...)))...((....))..((((.....)))).....).)))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((.(((((((.....(((...(((.((((...((..........))...)))).)))..)).).....)))))).).)..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[.....((((((.....(.....((..(((((..(((.....{.(((((......((...........))..............((......))...)))))...)))..))))).))...........]]].)...)))))).)))...)))))))((((.(..........).))))....))))))..(((.(...(((......(((.((((....)))).)))...)))..).)))........))))))(......((.....((((((.......))))))((((....((((...(..(((((((.............))))))....[[(((.(.(...(.(...(((....)))...).)...).)..(((((........)))))]]..(((((((((((...((((....((((..(.(..((((((((((((...{{..).))))))((..((((....((((((((.((.((.....)))).)))))..)))...[))))...))....((((....)))).....)))))...).)...))))(..).....))))...))....)))))))))...))).))......((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))............(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........((.((..((....))...)).))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((...((((.(((.(((((.((((((((((..((((.(..........(((....((......((((((((....))))))))...))..............))).).))))..))))))))))...(((.((((((.....)))))))))....))))).)))..))))...(((......[)))(((((...........].)))))([((...(((((.(...((((...........))))......(][.[[[).....).)))))...(((...((((..{.))))...))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((...((((((((......))))))..))..(((((.....))))).....)))))..)...))).))....(((((((....))).))))....))..)))))))))))[...(((((((...((((..((.((((.....(....)....)))).)).(((((...((((...(((((((((((.}}.))))))..)))))...)))).)))))...(((....(.((.....}.......)).)....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))).. Ribosomal protein paralogs bL31 and bL36; 23S ribsomal RNA 6i7v DB 119 2.9 RF00001 URS000080E133_562 30359641 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>> ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))) Ribosomal protein paralogs bL31 and bL36; 5S ribosomal RNA 6i7v CB 118 2.9 RF00001 URS000080E133_562 30359641 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<.....<<<<<<.............>>>>..>>....>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (((((((((.....((((((((....(((..((...(.....)...))....)))...)))))).)).((.......((((((((...)))))))).......))...))))))))). Ribosomal protein paralogs bL31 and bL36; 5S ribosomal RNA 6ia2 A 19 2.27 URS0000E60B9D_32630 31022205 32630 agagaacccggaguucccu ................... ................... Crystal structure of a self-complementary RNA duplex recognized by Com; RNA (5'-R(*AP*GP*AP*GP*AP*AP*CP*CP*CP*GP*GP*AP*GP*UP*UP*CP*CP*CP*U)-3') 6ia2 B 19 2.27 URS0000E60B9D_32630 31022205 32630 agagaacccggaguucccu ................... ................... Crystal structure of a self-complementary RNA duplex recognized by Com; RNA (5'-R(*AP*GP*AP*GP*AP*AP*CP*CP*CP*GP*GP*AP*GP*UP*UP*CP*CP*CP*U)-3') 6icz B 97 3.0 RF00020 URS000075BAAE_9606 30728453 0000244,0000353 0005682,0046540 9606 gguuucucuucagaucgcauaaaucuuucgccuuuuacuaaagauuuccguggagaggaacaacucugagucuuaacccaauuuuuugaggccuugc .<<<<<<<<<<<........<<<<<<<<...........>>>>>>>>...>>>>>>>>>>>.................................... .(.(((((((((....(...((((((((.(.......).)))))))).).))))))))).).................................... Cryo-EM structure of a human post-catalytic spliceosome (P complex) at 3.0 angstrom; U5snRNA 6icz F 97 3.0 RF00026 URS00001EC8D7_9606 30728453 0030621 0000244,0000353 0005688,0046540 9606 gugcucgcuucggcagcacauauacuaaaauuggaacgauacagagaagauuagcauggccccugcgcaaggaugacacgcaaauucgugaagcguu <<<<<.<<....>>>>>>>.....................................<<...<<<.....>>>....>>................... (((((.((....))))))).....................................((..((((.....)))..).))................... Cryo-EM structure of a human post-catalytic spliceosome (P complex) at 3.0 angstrom; U6snRNA 6icz G 84 3.0 30728453 9606 ggccuccgaacgguaagagccuagcauguagaacugguuaccuccaggguuuccuugaugaugucauacuuauccuguccacag .................................................................................... .................................................................................... Cryo-EM structure of a human post-catalytic spliceosome (P complex) at 3.0 angstrom; pre-mRNA 6icz H 140 3.0 RF00004 URS00003EE995_9606 30728453 0045131 0000348 0005686 9606 aucgcuucucggccuuuuggcuaagaucaaguguaguaucuguucuuuuaauaucguccucuaccgaggacaauauuaaggauuuuuggagcagggagccacgcaucgaccugguauugcaguaccuccaggaacggugc ...............................................<<<<<<<.<<<<<<....>>>>>>.>>>>>>>................<.....><<<<<<.<<<<<.............>>>>>..>>>>>> ...............................................(((((((.((((((....)))))).)))))))...............(......)(((.((.(((((.............)))))..)).))) Cryo-EM structure of a human post-catalytic spliceosome (P complex) at 3.0 angstrom; U2snRNA 6id0 B 98 2.9 RF00020 URS000075BAAE_9606 30728453 0000244,0000353 0005682,0046540 9606 ugguuucucuucagaucgcauaaaucuuucgccuuuuacuaaagauuuccguggagaggaacaacucugagucuuaacccaauuuuuugaggccuugc ...<<<<<<<<<<........<<<<<<<<.<.......>.>>>>>>>>...>>>>>>>>>>..................................... ....(((((((((....(...((((((((.(.......).)))))))).).)))))))))...................................... Cryo-EM structure of a human intron lariat spliceosome prior to Prp43 loaded (ILS1 complex) at 2.9 angstrom resolution; U5snRNA 6id0 F 97 2.9 RF00026 URS00001EC8D7_9606 30728453 0030621 0000244,0000353 0005688,0046540 9606 gugcucgcuucggcagcacauauacuaaaauuggaacgauacagagaagauuagcauggccccugcgcaaggaugacacgcaaauucgugaagcguu <<<<<.<<<..>>>>>>>>.....................................<<...<<<.....>>>....>>................... (((((.((....))))))).....................................((..((((.....)))..).))................... Cryo-EM structure of a human intron lariat spliceosome prior to Prp43 loaded (ILS1 complex) at 2.9 angstrom resolution; U6snRNA 6id0 G 70 2.9 30728453 9606 guaagagccuagcauguagaacugguuaccuccaggguuuccuugaugaugucauacuuauccugucccu ...................................................................... ...................................................................... Cryo-EM structure of a human intron lariat spliceosome prior to Prp43 loaded (ILS1 complex) at 2.9 angstrom resolution; pre-mRNA 6id0 H 140 2.9 RF00004 URS00003EE995_9606 30728453 0045131 0000348 0005686 9606 aucgcuucucggccuuuuggcuaagaucaaguguaguaucuguucuuaucauuaauaucguccucuaccgaggacaauauuaaggauuuuuggagcagggaggcaucgaccugguauugcaguaccuccaggaacggugc ......................................................<<<..<<<<<<....>>>>>>..>>>......................<<<<<<.<<<<<.............>>>>>..>>>>>> ...........................................................((((((....))))))...........................(((.((.(((((.............)))))..)).))) Cryo-EM structure of a human intron lariat spliceosome prior to Prp43 loaded (ILS1 complex) at 2.9 angstrom resolution; U2snRNA 6id1 B 98 2.86 RF00020 URS000075BAAE_9606 30728453 0000244,0000353 0005682,0046540 9606 ugguuucucuucagaucgcauaaaucuuucgccuuuuacuaaagauuuccguggagaggaacaacucugagucuuaacccaauuuuuugaggccuugc ...<<<<<<<<<<........<<<<<<<<...........>>>>>>>>...>>>>>>>>>>..................................... ....(((((((((....(...((((((((.(.......).)))))))).).)))))))))...................................... Cryo-EM structure of a human intron lariat spliceosome after Prp43 loaded (ILS2 complex) at 2.9 angstrom resolution; U5snRNA 6id1 F 97 2.86 RF00026 URS00001EC8D7_9606 30728453 0030621 0000244,0000353 0005688,0046540 9606 gugcucgcuucggcagcacauauacuaaaauuggaacgauacagagaagauuagcauggccccugcgcaaggaugacacgcaaauucgugaagcguu <<<<<.<<<..>>>>>>>>.....................................<<...<<<.....>>>....>>................... (((((.((....))))))).....................................((..((((.....)))..).))................... Cryo-EM structure of a human intron lariat spliceosome after Prp43 loaded (ILS2 complex) at 2.9 angstrom resolution; U6snRNA 6id1 G 68 2.86 30728453 9606 guaagagccuagcauguagaacugguuaccaggguuuccuugaugaugucauacuuauccugucccuu .................................................................... .................................................................... Cryo-EM structure of a human intron lariat spliceosome after Prp43 loaded (ILS2 complex) at 2.9 angstrom resolution; pre-mRNA 6id1 H 136 2.86 RF00004 URS00003EE995_9606 30728453 0045131 0000348 0005686 9606 aucgcuucucggccuuuuggcuaagaucaaguguaguaucuguucuuuuaauaucguccucuaccgaggacaauauuaaggauuuuuggagcagggaggcaucgaccugguauugcaguaccuccaggaacggugc ..................................................<<<..<<<<<<....>>>>>>..>>>......................<<<<<<.<<<<<.............>>>>>..>>>>>> .......................................................((((((....))))))...........................(((.((.(((((.............)))))..)).))) Cryo-EM structure of a human intron lariat spliceosome after Prp43 loaded (ILS2 complex) at 2.9 angstrom resolution; U2snRNA 6ifk N 34 3.2 URS0000E60B6F_767463 30503210 767463 acggaaacgcuuucuagcucgcuauaauuaccca .................................. .................................. Cryo-EM structure of type III-A Csm-CTR1 complex, AMPPNP bound; crRNA 6ifk J 33 3.2 URS0000E60B8C_767463 30503210 767463 aauggguaauuauagcgagcuagaaagccaaag ................................. ................................. Cryo-EM structure of type III-A Csm-CTR1 complex, AMPPNP bound; CTR1 6ifl I 35 3.16 URS0000E60BDC_767463 30503210 767463 acggaaacgcuuucuagcucgcuauaauuacccau ................................... ................................... Cryo-EM structure of type III-A Csm-NTR complex; crRNA 6ifl J 35 3.16 URS0000E60BCD_767463 30503210 767463 aauggguaauuauagcgagcuagaaagcguuuccg ................................... ................................... Cryo-EM structure of type III-A Csm-NTR complex; NTR 6ifr N 35 3.4 URS0000E60BDC_767463 30503210 767463 acggaaacgcuuucuagcucgcuauaauuacccau ................................... ................................... Type III-A Csm complex, Cryo-EM structure of Csm-NTR, ATP bound; type III-A CRISPR-Cas interference complex, crRNA 6ifr J 35 3.4 URS0000E60BCD_767463 30503210 767463 aauggguaauuauagcgagcuagaaagcguuuccg ................................... ................................... Type III-A Csm complex, Cryo-EM structure of Csm-NTR, ATP bound; type III-A CRISPR-Cas interference complex, NTR 6ifu I 34 3.05 URS0000E60BDC_767463 30503210 767463 acggaaacgcuuucuagcucgcuauaauuaccca .................................. .................................. Cryo-EM structure of type III-A Csm-CTR2-dsDNA complex; crRNA 6ifu J 28 3.05 URS0000E60BCC_767463 30503210 767463 aauggguaauuauagcgagcuagaaagc ............................ ............................ Cryo-EM structure of type III-A Csm-CTR2-dsDNA complex; CTR2 6ify I 34 3.8 URS0000E60BDC_767463 30503210 767463 acggaaacgcuuucuagcucgcuauaauuaccca .................................. .................................. Type III-A Csm complex, Cryo-EM structure of Csm-CTR1; crRNA 6ify J 28 3.8 URS0000E60B8C_767463 30503210 767463 aauggguaauuauagcgagcuagaaagc ............................ ............................ Type III-A Csm complex, Cryo-EM structure of Csm-CTR1; CTR1 6ifz I 34 3.58 URS0000E60BDC_767463 30503210 767463 acggaaacgcuuucuagcucgcuauaauuaccca .................................. .................................. Type III-A Csm complex, Cryo-EM structure of Csm-CTR2-ssDNA complex; crRNA 6ifz J 28 3.58 URS0000E60BCC_767463 30503210 767463 aauggguaauuauagcgagcuagaaagc ............................ ............................ Type III-A Csm complex, Cryo-EM structure of Csm-CTR2-ssDNA complex; CTR2 6ig0 N 34 3.37 URS0000E60BDC_767463 30503210 767463 acggaaacgcuuucuagcucgcuauaauuaccca .................................. .................................. Type III-A Csm complex, Cryo-EM structure of Csm-CTR1, ATP bound; crRNA 6ig0 J 33 3.37 URS0000E60B8C_767463 30503210 767463 aauggguaauuauagcgagcuagaaagccaaag ................................. ................................. Type III-A Csm complex, Cryo-EM structure of Csm-CTR1, ATP bound; CTR1 6ip5 1A 3717 3.9 RF02543,RF02540 URS0000E60B81_9606 31080011 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcggcccggcggaucuuucccgcgcgggggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucgggggcccccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcgcucuccccccucccggcgcgccggggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccgggggaggccacgcgcgcgucccccgaagagggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcagacccgacgcccgccacgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagcggcggcccggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcugggucggucgucggccggcgccuagcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacaugagagguguagaauaagugggaggcccgggccgccggugaaauaccacuacucugaucguuuuuucacugacccggugaggcgggggggcgagccccgaggggcucucgcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccggucccccgcgggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<<....<<....>>.....>>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..[[[..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>>..<<<<<<<<<....<<<<<<<<.<......<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>..>>>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<......>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<<<..<<<<<<<..<....<.....<<<<.<<<..<<<....>>>>>>>>>>.>...>..>>>>...>>>>>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<.<<<<<<<<<<.<<<<...<<..<<<....<<<<......<<<<<<<....>>>>>>>.......>>>>...>>>........>>>>>>...>>>>>>>>>>....................<<<<<<.<<<<<<<............>>>>>>>.<<<<<<.<<<<.<<<<<<<<<<<.<<<<<.<<<<..<...........>...>>>>.>>>>>.>.>>>>>>>.>>>...>>>>..>>>>.>>..<<<<<<<<<<.....>>>>>>>>.>>....>>>>>>......>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<......>>>>>>>..<<<<<...<<<..<<<..[[...(((.>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<......................<<<.<<<<<<<<<...<<<....<<<..<.<<<.....<.............>...>>>.>..>>>..>>.>...>>>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<..<<..<.....................>.......................>>..>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<...........)))...]]...<.....>..................>>>>>>>>>....>>>>>>.<<<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>.>>.....>>>>>><<<....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<....<...>....>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<....<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..{{{..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>.............>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<........................>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.....<<....<<<<<....>>>>.>...>>..>>>>..>>>>><<<............>>>.........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>...>>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<<.<<<<<<<<................................................................>>>>>>>>...<<<<<.....<<<<.........<.....>.....................<<<<<<<<<<<.....>>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))]......((((((..(((..>>>>>>.)))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>..>>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]].....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<}}}.>>>>>..>>.>>...>>>>...>>>><<.<....<<<<<...........>>>>>.....>>>.>>>...>.>>>>>>.....<<<<<<<.<...<<<.....<<.........<<<<<..<.<<..>>>..>>>>>........>>..........<<....<<<<.<<<<<<<......>>>>>>>>>>>....>>....................>>>...>.>>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<....<<<<<......>>>>>...>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......))))..)........((....))...((((......((.]...)).....))))...((((...(((...((((((((((.....)))))).)))).....)))....(((((((((....(((((((.((......((((((((..({((((......)))))....[[(...).(((....}]])))...).)))))))..)))))))))...)))))))))..)....(((((((........)))))))......((((..[[[[[[))))...)))..................................((....))............(..((((....))))............).....................((((((((..(((..(...((((((((.(((.....(((((((((((..(((((((.......((.....(((.((....(......)..))))).))......))))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((..(.((((......(.(((((....))))).).......))))..))))........))))))..)))))))))))....................((((((..(((((..............)))))..((((((.((((.(((((((((((.(((((.(.((..................)).).))))).).))))))).)))...))))..)))).))..((((((((((.....)))))))).))..[.)))))).....))).)))))...).)))...)))))))).<((((........))))((((((....(((((((((((((..(((..((((..........)))..)..)))...((....))...(((((.(......).)))))..(((((...(((..(((..[.....[[[)))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((........)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((......................(((.((((((((....(((....((...(.(((..(..................).))).)...))..)).)....))))))...(((((((((.(......))))))))))....))))))))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.......((.((.................................(............).)).))...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((..........]]].....]]...........................)))))))))....)))))).(.((((((.(.((......((((.((((....))))))))...))).))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..(....((((((....(.....)..))))))....[[((..((...((....(((....)))..........((.(..(....(....)...)..)))......))....))...(((((........)))))]]((((....(((.....((.((((....)))).))..((((....)))...(...((((((...(((((((((((((((((.(((((..{{{..))))).....(((((.((((.((((.....(((.....))).....))))))))..))))).....(((((((.......))))))))))).).))))))))))))(...)....))))))...))............))).))))..))...).....((......)).)))).((((.....))))..)))....((((.....((((((..((..(............(((((....(....).....)))))((.(((((((((((........................)))))..)))))).))(...).......(((((((((.>.((.........)).....(((((....((((.....))))......))))).....(((.(((..((((((.....(.....(((((....)))).)....)..))))..))))).(.(...........))..........((.(......).(((((.......)))))..)..)....)))....)).)))))))....)))..))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.(.......((((.(.((((..(((((.(((((((((.((((((((................................................................))))))))...((((......((((.....(..............)................(((((((((((.....)))))))))))..))))...))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(..((.(((((....{..)))).))).)(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))...))))).......(..(.(..(((((...((.......))...)))))....))...)........((((.((((((..(.(.((((........))))...).).(((.........))).....)))))..)...))).).....(..((((....))).)..).....)..))).))))).....((((((....(((..(.(((((......(....).....))))).)((((....(.......((.(((((((}}}.)))))..)).))......)...))))..((....((((.............)))).....))..))).....)))))).....(((((((.(...((......((..........((((.............)))).........)).........(((....((((.(((((((......)))))))))))....)).)...................))...).)))))))(((((.(..(.......)..)....((.(((((((.((.....((((....(((((......)))))...))))....))....)))).))).))..))))).. Cryo-EM structure of the CMV-stalled human 80S ribosome (Structure ii); 28S ribosomal RNA 6ip5 1B 120 3.9 RF00001 URS00000F9D45_9606 31080011 0003735 0005840 9606 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<<............>>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((..((...(....)...))....))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. Cryo-EM structure of the CMV-stalled human 80S ribosome (Structure ii); 5S ribosomal RNA 6ip5 1C 156 3.9 RF00002 URS0000005270_9606 31080011 0003735 0005840 9606 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<.<<.....>>>.......<<<......>>.............>>>......>>>....<<....>><<<<<<<<<.....>>>>>>>>>.................... .........................................(((((..[[......)).....(.(((......]].............)))..)...)))....((....))((((((((.......)))))))).................... Cryo-EM structure of the CMV-stalled human 80S ribosome (Structure ii); 5.8S ribosomal RNA 6ip5 2m 1742 3.9 RF01960,RF01959,RF00177 URS0000868520_9606 31080011 0003735 0005840 9606 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucgcuccucucccacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgccccccguggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuccgcgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcgggcguccccgccgccucucggccggggcccgaagcauuuacuuugaaaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggucggcccacggcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<........<...<<.....................<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<<<....>>>>>>...>>>><...<<<<<...<......>..>>>>>........>..<<<<.<<<<......>>>>>>>>.....>>...>.....>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>..>>>..>...>>.>.....<<....<<<............>>.>.....>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<................................................<<<<<<.<.......<<...<.......>.<<<<.......>>>>...>>......>.>>>..>>>.......<<....<<..<..................>...>>...>>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<.......<<<<....>>>>.....>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<.......<<........>>..........<<<<<......<<<<<........<<..<<........>>..>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<...<............<........>...........>...>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.......>>>>>....>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<..<....<<<<<<<<.<<<..<<<<.<<...<<<<<...<<<...................>>>.....>>>>>...>>.>>>>..>>>.>>>>>>>>...>..>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))(((.((.(((...(.((..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(...((...(.(....................((.....((.(((.....))).))......)).........((.....(((((......))))).....))....(((((...(......)..)))))...........((((.(.(........).))))).....))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((.(.]....)).))))).)...)).).....((.((.(((............)).).))..))......((.................)).........((((([[......((((.....((..]])).......)))).)))))..))).)).)))..[......(.([[...(.(.((....((..(................................................((((((.(.......((..((.......)).(((.......)))....))......).)))..))).......(..(..(....(................).....)..).)....)....((...(.(.(...((((..(((.((((((((...((........))......)))))))).))).......((....))...))))..)..))....)..)))....)).)....(.(((.....(...((((.........))))...)..))).)......{...(((.((.(((..(.((((((.((..........)))))))).)..)))...((..]]))...))...].))))).).((.......(((......))).....))...]]].]((.(..((((((...((..(((((..(((.((((((.......(........)...........(((((.(....(((.(............((........))..........).)))....(.(((...(.((((((.(..(((.(((((....)))..(.((......)))...)).)))....(((...(...(.((................(........)...............)).)..)..(..(((((.....)))))....)...))).)..))).))).....).))))......).)))))...)).)))).))).(...((.(((........(.......((..((((....))))..))....).........))).))......(.....(((((..........))))).....)..)..))))).....(.(((.((.......)).))).)......))....)))))).)..))..(.(..((.(..(.((..(..(.((((((((.(((..(((.(((...((.((.(..(.....................)..)...)).))...)).))))..))).)))))))))...).)).)...).))...)..)..(((((((((....)))))))))}........ Cryo-EM structure of the CMV-stalled human 80S ribosome (Structure ii); 18S ribosomal RNA 6ip5 zy 75 3.9 RF00005 URS0000416117_9606 31080011 0030533 0006412 9606 ggcucguuggucuagggguaugauucucgcuuagggugcgagaggucccggguucaaaucccggacgagccccca <<<<<<<..<<<.........>>><<<<<<.......>>>>>>....<<<<<.......>>>>>>>>>>>>.... (((((((..(((.....[...)))((((((.......))))))....(((((..]....))))))))))).)... Cryo-EM structure of the CMV-stalled human 80S ribosome (Structure ii); P-site tRNA 6ip5 zu 75 3.9 RF00005 URS0000416117_9606 31080011 0030533 0006412 9606 ggcucguuggucuagggguaugauucucgcuuagggugcgagaggucccggguucaaaucccggacgagccccca <<<<<<<..<<<.........>>><<<<<<.......>>>>>>....<<<<<.......>>>>>>>>>>>>.... (((((((...((.....[...))..(((((.......))))).....(((((..]....)))))))))))).... Cryo-EM structure of the CMV-stalled human 80S ribosome (Structure ii); P-site tRNA 6ip6 1A 3667 4.5 RF02543,RF02540 URS0000E60B81_9606 31080011 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcggcccggcggaucuuucccgcgcgggggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucgggggcccccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcgcucuccccccucccggcgcgccggggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccgggggaggccacgcgcgcgucccccgaagagggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcagacccgacgcccgccacgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagcggcggcccggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcugggucggucgucggccggcgccuagcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacaugagugaucguuuuuucacugacccggugaggcgggggggcgagccccgaggggcucucgcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccggucccccgcgggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..[[[..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>>..<<<<<<<<<....<<<<<<<.<<......<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>..>>>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<......>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<<<..<<<<<<<..<....<<....<<<<.<<<..<<<....>>>>>>>>>>>>...>..>>>>...>>>>>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<.<<<<<<<<<<.<<<<...<<..<<<....<<<<......<<<<<<<....>>>>>>>.......>>>>...>>>........>>>>>>...>>>>>>>>>>....................<<<<<<.<<<<<<<............>>>>>>>.<<<<<<.<<<<.<<<<<<<<<<..<<<<<.<<<<..<...........>...>>>>.>>>>>...>>>>>>>.>>>...>>>>..>>>>.>>..<<<<<<<<<<.....>>>>>>>>.>>....>>>>>>......>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<......>>>>>>>..<<<<<...<<<..<<<..[....((((>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<......................<<<.<<<<<<<<<...<<<....<<<..<.<<<.....<.............>...>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<..<<.<<.....................>>......................>>..>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<..........))))....]...<.....>..................>>>>>>>>>....>>>>>>.<<<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>.>>.....>>>>>><<<....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<.....<...>.....>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<....<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..{{{..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>.............>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<........................>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.....<<....<<<<<....>>>>.>...>>..>>>>..>>>>><<<............>>>.........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>...>>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<<.<<<<<<<<..............>>>>>>>>...<<<<<.....<<<<.........<.....>.....................<<<<<<<<<<<.....>>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))]......((((((..(((..>>>>>>.)))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]].....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<}}}.>>>>>..>>.>>...>>>>...>>>><.<<....<<<<<...........>>>>>.....>>>.>>>...>.>>>>>>.....<<<<<<<.<...<<<..<..<<.........<<<<<..<.<<..>>>..>>>>>........>>..........<<....<<<<.<<<<<<<......>>>>>>>>>>>....>>................>...>>>...>.>>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<....<<<<<......>>>>>...>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......))))..)........((....))...((((......((.]...)).....))))...((((...(((...((((((((((.....)))))).)))).....)))....(((((((((....(((((((.((......((((((((..({((((......)))))....[[(...).(((....}]])))...).)))))))..)))))))))...)))))))))..)....(((((((........)))))))......((((..[[[[[[))))...)))..................................((....))............(..((((....))))............).....................((((((((..(((..(...((((((((.(((.....(((((((((((..(((((((....(..((.....(((.(((...(......).)))))).)).)....))))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((..(.((((......(.(((((....))))).).......))))..))))........))))))..)))))))))))....................((((((..((((((............))))))..((((((.((((.(((((((((((.(((((.((((..................)))).))))).).))))))).)))...))))..)))).))..((((((((((.....)))))))).))..[.)))))).....))).)))))...).)))...)))))))).<((((........))))((((((....(((((((((((((..(((..((((..........)))..)..)))...((....))...(((((.(......).)))))..(((((...(((..(((..[.....[[[)))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))....((..((.((........)))).))...).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((......................(((.((((((((....(((....((...(.(((..(..................).))).)...))..)).)....))))))...(((((((((.(......))))))))))....))))))))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.......((.((..(....................)........................)).))...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((..........]]].....]]...........................)))))))))....)))))).(.((((((.(.((......((((.((((....))))))))...))).))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..(....((((((....(.....)..))))))....[[((..((...((....(((....)))..........((.(..(....(....)...)..)))......))....))...(((((........)))))]](((.....(((.....((.((((....)))).))..((((....)))...(...((((((...(((((((((((((((((.(((((..{{{..))))).....(((((.((((.((((.....(((.....))).....))))))))..))))).....(((((((.......))))))))))).).))))))))))))(...)....))))))...))............)))..)))..))...).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(............(((((....(....).....)))))((.(((((((((((........................)))))..)))))).))(...).......(((((((((.>.((.........)).....(((((....((((.....))))......))))).....(((.(((..((((((.....(......((((....))))......)..))))..))))).(..............)..........((.(......).(((((.......)))))..)..)....)))....)).)))))))....))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.(.......((((.(.((((..(((((.(((((((((.(((((.((..............)).)))))...(((((.....((((.....(..............)................(((((((((((.....)))))))))))..))))..)))))....)))))))))..)))))..(((......[)).)(((((...........].)))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(..((..((((....{..))))..)).)(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))...))))).......(..(.(..(((((...((.......))...)))))....))...)........((((.((((((..(.(.((((........))))...).).(((.........))).....)))))..)...))).).....(.(((((....))).)).).....)..))).)))))......(((((....(((..(.(((((......(....).....))))).)((((....(.(.....((.(((((((}}}.)))))..)).)).....))...))))..((....((((.............)))).....))..))).....)))))......(((((((.(...((......((..........((((.............)))).........)).....(....((....((((.(((((((......)))))))))))....)).....)...............))...).)))))))(((((.(..(.......)..)....((.(((((((.((.....((((....(((((......)))))...))))....))....)))).))).))..))))).. Cryo-EM structure of the CMV-stalled human 80S ribosome with HCV IRES (Structure iii); 28S ribosomal RNA 6ip6 1B 120 4.5 RF00001 URS00000F9D45_9606 31080011 0003735 0005840 9606 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<<............>>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((..((...(....)...))....))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. Cryo-EM structure of the CMV-stalled human 80S ribosome with HCV IRES (Structure iii); 5S ribosomal RNA 6ip6 1C 156 4.5 RF00002 URS0000005270_9606 31080011 0003735 0005840 9606 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<.<<.....>>>.....(.<<<......>>.............>>>..)...>>>....<<....>><<<<<<<<<.....>>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))((((((((.......)))))))).................... Cryo-EM structure of the CMV-stalled human 80S ribosome with HCV IRES (Structure iii); 5.8S ribosomal RNA 6ip6 2m 1742 4.5 RF01960,RF01959,RF00177 URS0000868520_9606 31080011 0003735 0005840 9606 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucgcuccucucccacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgccccccguggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuccgcgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcgggcguccccgccgccucucggccggggcccgaagcauuuacuuugaaaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggucggcccacggcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<........<...<<<....................<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<<<....>>>>>>...>>>><...<<<<<...<......>..>>>>>........>..<<<<..<<<......>>>.>>>>....>>>...>.....>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>...<<....>>.....>>>>>>.........<<<....<<<.....>>>..>>>..>...>>.>.....<<....<<<............>>.>.....>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<................................................<<<<<<.<.......<<...<.......>.<<<<.......>>>>...>>......>.>>>..>>>.......<<....<<..<<................>>...>>...>>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<........>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<.......<<<<....>>>>.....>>..)))).]<<<<<.<<<<<<<..<<..<<<<<.<<<<.<<<<<<......<<........>>..........<<<<<......<<<<<........<<..<<........>>..>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<......>>...<<<......>>>...>>.>>>....<<<...<...<<<<................<........>...............>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.......>>>>>...>>.>>>>.>>>.>...<<.<<<................<<<.<<<<....>>>>.>>>..............>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<...<<<...................>>>.....>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))(((.((.(((...(.((..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(...((...(.(((..................((.....((.(((.....))).))......)).........((.....(((((......))))).....))....(((((...(......)..)))))...........((((.(((........))))))).))..))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...(.((.]....)).))))).)...)).).....((.(..(((............)).)..)..))......(...................).........((((([[......((((.....((..]])).......)))).)))))..))).)).)))..[......(.([[...(.(.((...(((..(................................................((((((.(.......((..((.......)).(((.......)))....))......).)))..))).......(..(..(....(................).....)..).)....)....((...(...(...((((..((..((((((((...((........))......))))))))..)).......((....))...))))..)...)....)..))))...)).)....(((((.....(...((((.........))))...)..)))))......{...(((.((.(((..(.((((((.((((......)))))))))).)..)))...((..]]))...))...].))))).).(........((((....))))......)...]]].]((.((.(((((((..((..(((((..(((.((((((.......(........)...........(((((.(....(((.(.........(..((........))....).....).)))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((...(...(.((................(........)...............)).)..)..(..(((((.....)))))....)...)))....))).))).....).))))).....).)))))...)).)))).))).(...((.(((........(.......((..((((....))))..))....).........))).))......(.....(((((..........))))).....)..)..))))).....(.(((.((.......)).))).)......))...)))))))))..))..(.(..((.(..((((.((..(.((((.((..(((..(.((.((...((.((.(...(....................)..)...)).))...)).)).)..)))..)).)))))..)).))))...).))...)..)..(((((((((....)))))))))}........ Cryo-EM structure of the CMV-stalled human 80S ribosome with HCV IRES (Structure iii); 18S ribosomal RNA 6ip6 zy 75 4.5 RF00005 URS0000416117_9606 31080011 0030533 0006412 9606 ggcucguuggucuagggguaugauucucgcuuagggugcgagaggucccggguucaaaucccggacgagccccca <<<<<<<..<<<.........>>><<<<<<.......>>>>>>....<<<<<.......>>>>>>>>>>>>.... (((((((..(((.....[...)))((((((.......))))))....(((((..]....))))))))))).)... Cryo-EM structure of the CMV-stalled human 80S ribosome with HCV IRES (Structure iii); P-site tRNA 6ip6 zz 163 4.5 RF00061 URS0000EEAD00_9606 31080011 0043022 9606 ccccucccgggagagccauaguggucugcggaaccggugaguacaccggaauugcgagauuugggcgugcccccgcgagacugcuagccgaguaguguugggucgcgaaaggccuugugguacugccugauagggugcuugcgagugccccgggaggucucgu ..<<<<<<<<<<<.<<<<<<<<<<.<<<<<<..<<<<<<....>>>>>><<<<....>>>>.<<<<..>>>>>>>>>.>.>>>>>><<<.....<<........>>....>>>....>>>>.>><<<<....>>>><<...((((.>>>>>>>>>>>.)))). ..(((((((((((..((((((..(.((((((..((((((....))))))(((......))).((((..)))))))).)).)..)))(((.....(..........)....)))(..)))).[))((((..].))))((...[[[[.))))))))))).]]]]. Cryo-EM structure of the CMV-stalled human 80S ribosome with HCV IRES (Structure iii); HCV-IRES RNA 6ip8 1A 3667 3.9 RF02543,RF02540 URS0000E60B81_9606 31080011 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcggcccggcggaucuuucccgcgcgggggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucgggggcccccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcgcucuccccccucccggcgcgccggggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccgggggaggccacgcgcgcgucccccgaagagggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcagacccgacgcccgccacgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagcggcggcccggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcugggucggucgucggccggcgccuagcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacaugagugaucguuuuuucacugacccggugaggcgggggggcgagccccgaggggcucucgcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccggucccccgcgggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..[[[..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>>..<<<<<<<<<....<<<<<<<.<<......<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>..>>>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<<<..<<<<<<<..<....<.....<<<<.<<<..<<<....>>>>>>>>>>.>...>..>>>>...>>>>>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<.<<<<<<<<<<.<<<<...<<..<<<....<<<<......<<<<<<<....>>>>>>>.......>>>>...>>>........>>>>>>...>>>>>>>>>>....................<<<<<<.<<<<<<<............>>>>>>>.<<<<<<.<<<<.<<<<<<<<<<<.<<<<<.<<<<..<...........>...>>>>.>>>>>.>.>>>>>>>.>>>...>>>>..>>>>.>>..<<<<<<<<<<.....>>>>>>>>.>>....>>>>>>......>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<......>>>>>>>..<<<<<...<<<..<<<..[[...((((>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<......................<<<.<<<<<<<<<...<<<....<<<..<.<<<.....<.............>...>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>>>>>>.>>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<..........<..<<.....................>>.......................>......>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<..........))))...]]...<.....>..................>>>>>>>>>....>>>>>>.<<<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>.>>.....>>>>>><<<....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<.<...<...>...>.>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<....<<<<<<.....>.>>>>>...<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<<<<<<<<<<<<..{{{..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>.>.>>>>>>>>>>>>.........>>>>>>>..>..........>..>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<...............<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<......<.....>...........>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.....<<.....<<<<....>>>>.....>>..>>>>..>>>>><<<............>>>.........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>...>>>....<<<<<........>>>>>.....[[[[..{{{.{{......[[[[.{.[[[[..<<<<<.<<<<<<<<<.<<<<<<<<.<..........>.>>>>>>>>...<<<<<.....<<<<.........<.....>.....................<<<<<<<<<<<.....>>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))]......((((((..(((..>>>>>>.)))))))))..........]]]]...}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]......<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<.}}}..>>>>..>>.>>...>>>>...>>>><.<<....<<<<<...........>>>>>.....>>>.>>>...>.>>>>>>.....<<<<<<<.<...<<<.....<<.........<<<<<..<<<<..>>>>.>>>>>........>>..........<<....<<<<.<<<<<<<......>>>>>>>>>>>....>>....................>>>...>.>>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<....<<<<<......>>>>>...>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((...((((((((((.....)))))).)))).....)))....(((((((((....(((((.(.((......(((((.((..({((((......)))))....[[(...).(((....}]])))...).).)))))..))).)))))...)))))))))..)....(((((((........)))))))......((((...[[[[[))))...)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....(((((((((((..(((((((.......((.....(((.((....(......)..))))).))......))))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((..(.((((......(.(((((....))))).).......))))..))))........))))))..)))))))))))....................((((((..((((((............))))))..((((((.((((.(((((((((((.(((((.(.((..................)).).))))).).))))))).)))...))))..)))).))..((((((((((.....)))))))).))..[.)))))).....))).)))))...)))))...)))))))).<((((........))))((((((....(((((((((((((..(((..((((..........)))..)..)))...((....))...(((((.(......).)))))..(((((...(((..(((..[.....[[[)))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((......................(((.((((((((....(((....((...(.(((..(..................).))).)...))..)).)....))))))...(((((((((.(......))))))))))....))))))))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[.....(.(((((......(..........(((.((((((((((.......((.((.................................(............).)).))...)))))))))))))..........]]].)....)))))).)))...)))))))((((((.(((..........]]].....]]...........................)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.......((((.......))))...(((.....((((..((...((((((...((.....)).))))))......(((.((...((....(((....)))..........((.(..(.............)..)))......))....))...(((((........)))))..((((....(((.....((.(..........).))..((((....)))...(...((((((...(((((((((((((((((((((((..{{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((.((((.......)))).)))))).).))))))))))))(...)....))))))...))............))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(........((.(....(....)......))).((.(((((.(((((........................)))))...))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......)))))))...(((.(((..((((((.....(......((.(.....)))......)..))))..))))).(.(...........))..........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.(.......((((.(..(((..(((((.(((((((((.((((((((..............))))))))...(.(((.....((((.....((............))................((((((((((.......))))))))))..))))..)).))....)))))))))..)))))....(......[).....(((...........].)))..([((...((.((((.(..(((((.......)))).)...).(.]..[[[.)....)))).).)(.(((..((((....{..))))..))))(((....))).))]]].......((((((..(((..]]]]]..)))))))))....)}....)))....))))).......(..(.(..(((((...((.......))...)))))....))...)........((((.(.((((..(.(.(((((......)))))...).).(((.(.....).))).....))).)..)...))).).....(((((((....))).))))..a..)..))).)))))......(((((....(((..(.(((((......(....).....))))).)((((....(.((....((.(((((((}}}.)))))..)).))...).))...))))..((....((((.............)))).....))..))).....)))))......((((((..(...((......((..........((((.............)))).........))..........((....((((.(((((((......)))))))))))....)).....................))...)..))))))(((((.(..(.......)..)....((.(((((((.((.....((((....(((((......)))))...))))....))....)))).))).))..))))).. Cryo-EM structure of the HCV IRES dependently initiated CMV-stalled 80S ribosome (Structure iv); 28S ribosomal RNA 6ip8 1B 120 3.9 RF00001 URS00000F9D45_9606 31080011 0003735 0005840 9606 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<<............>>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. ((((((.((....((((((((.....((..((...(....)...))....))....)))))).))((((((......((.((..((....)).)).)).....)))))))).)))))).. Cryo-EM structure of the HCV IRES dependently initiated CMV-stalled 80S ribosome (Structure iv); 5S ribosomal RNA 6ip8 1C 156 3.9 RF00002 URS0000005270_9606 31080011 0003735 0005840 9606 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<.<<.....>>>.....(.<<<......>>.............>>>..)...>>>....<<....>><<<<<<<<<.....>>>>>>>>>.................... .........................................(((((..[[......)).....(.(((......]].............)))..)...)))....((....))(((((.((.......)).))))).................... Cryo-EM structure of the HCV IRES dependently initiated CMV-stalled 80S ribosome (Structure iv); 5.8S ribosomal RNA 6ip8 2m 1742 3.9 RF01960,RF01959,RF00177 URS0000868520_9606 31080011 0003735 0005840 9606 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucgcuccucucccacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgccccccguggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuccgcgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcgggcguccccgccgccucucggccggggcccgaagcauuuacuuugaaaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggucggcccacggcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<....((((.>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<....<<....<<.....................<<.....<<..<<.....>>..>>......>>.........<<<<...<<<<<......>>>>>...>>>>....<<<<<.............>>>>>...........<<<<.<<<<......>>>>>>>>.....>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>..>>>..>...>>.>.....<<...<<<<............>>.>>....>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<..<................................................<<<<<<.<.......<<...<.......>.<<<<.......>>>>...>>......>.>>>..>>>.......<<....<.<<<<................>>.>>.>...>>....>.....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>.>.>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<....<...<<<<.........>>>>...>.>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<........>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..))))..<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<........<<........>>..........<<<<<......<<<<<........<<..<<........>>..>>......>>>>>...<<.<<<...<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<...........<........>..........>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>.>>>>>.......>>>>>......>>>>.>>>.....<<.<<<................<<<.<<<<....>>>>.>>>..............>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<.<..<<...................>>..>...>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>..........<<<<<<<<....>>>>>>>>.......... ...((((...[[[[..))))(((.((.(((...(.((..((.....(((.(((..((....((.....(..........)....))[))......(((.......(((.(.(..(.......(....................((.....((..((.....))..))......)).........((((...((((........))))...))))....(((((....(.....)..)))))...........((((..((........)).)))).....).....)).).))).(((.....((....(((((((.........))))))))).......)))...(((.(((......)))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...(.((.]....)).))))).)...)).).....((.(..(((............)).)..)..))......((.................)).........((((([[.......(((.....((..]])).......)))..)))))..))).)).)))..[......(.([[...(.(.((...(((..(................................................((((((.(.......((..(.........).(((.......)).)...))......).)))..))).......(..(..(....(................).....)..).)....)....(((..(...(...((((..((..((((((((...((........))......))))))))..)).......((....))...))))..)...)...))..))))...)).)....(((((.....(...((((.........))))...)..)))))......{....((.((.(((..(.((((((.((((......)))))))))).)..)))...((..]]))...))...].)).)).).((.......((((....)))).....))...]]].]((.((.(((((((..((..(((((..(((.(..(((......((........))..........(((((.(....(((.(.............(........)...........).)))...((.(((...(.((((((.(..(((.((.((....))...(.((......)))...)).)))....(((...(...(.((..(.............(........)............)..)).)..)..(..(((((.....)))))....)...))).)..))).))).....).)))).)....).)))))...)).)..).))).(...((.(((........(.......(((.((((....)))).))).....)........))).))......(......((((..........)).)).....)..)..))))).....(.(((.((.......)).))).)......))...)))))))))..))..(.(..((.(..((((..(..(..(((((((.(((..(.(.(((...((.((.(..(.....................)..)...)).))...)).)).)..))).))))))).)...).))))...).))...)..)..((((((((......))))))))}........ Cryo-EM structure of the HCV IRES dependently initiated CMV-stalled 80S ribosome (Structure iv); 18S ribosomal RNA 6ip8 zv 12 3.9 31080011 9606 ccgccuuaacuc ............ ............ Cryo-EM structure of the HCV IRES dependently initiated CMV-stalled 80S ribosome (Structure iv); mRNA 6ip8 zy 75 3.9 RF00005 URS0000416117_9606 31080011 0030533 0006412 9606 ggcucguuggucuagggguaugauucucgcuuagggugcgagaggucccggguucaaaucccggacgagccccca <<<<<<<..<<<.........>>><<<<<<.......>>>>>>....<<<<<.......>>>>>>>>>>>>.... (((((((..(((.....[...))).(((((.......))))).....(((((..]....)))))))))))).... Cryo-EM structure of the HCV IRES dependently initiated CMV-stalled 80S ribosome (Structure iv); P-site tRNA 6ip8 zz 163 3.9 RF00061 URS0000EEAD00_9606 31080011 0043022 9606 ccccucccgggagagccauaguggucugcggaaccggugaguacaccggaauugcgagauuugggcgugcccccgcgagacugcuagccgaguaguguugggucgcgaaaggccuugugguacugccugauagggugcuugcgagugccccgggaggucucgu ..<<<<<<<<<<<.<<<<.<<<<<<<<<<<<..<<<<<<....>>>>>><<<<....>>>>.<<<<..>>>>>>>>>.>>>>>>>.<<<.....<<........>>....>>>....>>>>.>><<<<....>>>><<...((((.>>>>>>>>>>>.)))). ..(((((((((((..((((((.((.((((((..((((((....))))))((((.().)))).((((..)))))))).)).)).)))(((.....(..........)....)))(..)))).[))((((..].))))((...[[[[.))))))))))).]]]]. Cryo-EM structure of the HCV IRES dependently initiated CMV-stalled 80S ribosome (Structure iv); HCV-IRES RNA 6j6g B 60 3.2 30879786 559292 acaauggauucugguauguucuagcgcuuguacuaagucucauguacuaacaucgauugc ............................................................ ............................................................ Cryo-EM structure of the yeast B*-a2 complex at an average resolution of 3.2 angstrom; ACT1 pre-mRNA 6j6g D 179 3.2 RF00020 URS000053F313_559292 30879786 0000244,0000353 0005682,0046540 559292 aagcagcuuuacagaucaauggcggagggaggucaacaucaagaacugugggccuuugccuauagaacuuauaacgaacaugguucuugccuuuuaccagaaccauccggguguugucuccauagaaacagguaaagcuguccguuacugugggcuugccauauuuuuuggaacuuuuc ...<<<<<.<<<<<.......<<<<..<<<<<.<<<<<<<.....<<<<<<<<....>>>>>>>>..............<<<<<<<<...........>>>>>>>>...>>>>>>>>>>>>......<<<<......>>>>>>>>..>>>>>>>>.>>..................... ...((((((.((((........(((..(((((.(((((((.....((((((((....)))))))).........((...((((((((.(.......).)))))))).))))))))))))))......((((......)))))))...)))))))).))..................... Cryo-EM structure of the yeast B*-a2 complex at an average resolution of 3.2 angstrom; U5 snRNA 6j6g E 103 3.2 RF00026 URS00006184A9_559292 30879786 0030621 0000244,0000353 0005688,0046540 559292 guucgcgaaguaacccuucguggacauuuggucaauuugaaacaauacagagaugaucagcaguuccccugcauaaggaugaaccguuuuacaaagagauuua <<<<<<<<<<.....>>>>>>>>>>.....................................<<<..<<<.....>>>...>>>................... ((((((((((.....)))))))))).....................................(((.((((.....)))..))))................... Cryo-EM structure of the yeast B*-a2 complex at an average resolution of 3.2 angstrom; U6 snRNA 6j6g L 208 3.2 RF00004 URS000023C730_559292 30879786 0045131 0000348 0005686 559292 acgaaucucuuugccuuuuggcuuagaucaaguguaguaucuguucuuuucauguaacaacuaaugaccucagaggcucaauuuguuacaauacacauuuuuuggcacccaaaauaggacgggaagagacuuuuaaagugagacgucgcgacccucgcaggagucguucuugacuuuuuggucgcuugauguuucucucuucccguuc ....................................................<<<<<<<<.....<.<<<<.>>>>.>....>>>>>>>>...........................<<<<<<<<<<.<<<<<.>>>>><<<<<<<<<<<<.<<......<<<<<<....>>>>>>...>>>>>>..>>>>>>>>..>>>>>>>>>>. ....................................................((((((((.(.....((((.))))....).))))))))..........................(.(((((((((.(((((.)))))((((((((((((.((.......(((((....)))))....))))))..))))))))..))))))))).) Cryo-EM structure of the yeast B*-a2 complex at an average resolution of 3.2 angstrom; U2 snRNA 6j6h B 60 3.6 30879786 559292 acaauggauucugguauguucuagcgcuuguacuaagucucauguacuaacaucgauugc ............................................................ ............................................................ Cryo-EM structure of the yeast B*-a1 complex at an average resolution of 3.6 angstrom; ACT1 pre-mRNA 6j6h D 179 3.6 RF00020 URS000053F313_559292 30879786 0000244,0000353 0005682,0046540 559292 aagcagcuuuacagaucaauggcggagggaggucaacaucaagaacugugggccuuugccuauagaacuuauaacgaacaugguucuugccuuuuaccagaaccauccggguguugucuccauagaaacagguaaagcuguccguuacugugggcuugccauauuuuuuggaacuuuuc ...<<<<<<.<<<<.......<<<<..<<<<<.<<<<<<<.....<<<<<<<<....>>>>>>>>..............<<<<<<<<...........>>>>>>>>...>>>>>>>>>>>>......<<<<......>>>>>>>>..>>>>>>>>.>>..................... ...((((((.((((........(((..(((((.(((((((.....((((((((....)))))))).........((...((((((((.(.......).)))))))).))))))))))))))......((((......)))))))...)))))))).))..................... Cryo-EM structure of the yeast B*-a1 complex at an average resolution of 3.6 angstrom; U5 snRNA 6j6h E 103 3.6 RF00026 URS00006184A9_559292 30879786 0030621 0000244,0000353 0005688,0046540 559292 guucgcgaaguaacccuucguggacauuuggucaauuugaaacaauacagagaugaucagcaguuccccugcauaaggaugaaccguuuuacaaagagauuua <<<<<<<<<<.....>>>>>>>>>>.....................................<<<..<<<.....>>>...>>>................... ((((((((((.....)))))))))).....................................(((.((((.....)))..))))................... Cryo-EM structure of the yeast B*-a1 complex at an average resolution of 3.6 angstrom; U6 snRNA 6j6h L 209 3.6 RF00004 URS000023C730_559292 30879786 0045131 0000348 0005686 559292 acgaaucucuuugccuuuuggcuuagaucaaguguaguaucuguucuuuucaguguaacaacuaaugaccucagaggcucaauuuguuacaauacacauuuuuuggcacccaaaauaggacgggaagagacuuuuaaagugagacgucgcgacccucgcaggagucguucuugacuuuuuggucgcuugauguuucucucuucccguuc .....................................................<<<<<<<<.....<.<<<<.>>>>.>....>>>>>>>>...........................<<<<<<<<<<.<<<<<.>>>>><<<<<<<<<<<<.<<......<<<<<<....>>>>>>...>>>>>>..>>>>>>>>..>>>>>>>>>>. .....................................................((((((((.(.....((((.))))....).))))))))..........................(.(((((((((.(((((.)))))((((((((((((.((.......(((((....)))))....))))))..))))))))..))))))))).) Cryo-EM structure of the yeast B*-a1 complex at an average resolution of 3.6 angstrom; U2 snRNA 6j6n B 57 3.86 30879786 559292 gugaucuagaaagguaugucuaaaguuacuuaugcucuuauuuacuaacaaaaucaa ......................................................... ......................................................... Cryo-EM structure of the yeast B*-b1 complex at an average resolution of 3.86 angstrom; UBC4 pre-mRNA 6j6n D 179 3.86 RF00020 URS000053F313_559292 30879786 0000244,0000353 0005682,0046540 559292 aagcagcuuuacagaucaauggcggagggaggucaacaucaagaacugugggccuuugccuauagaacuuauaacgaacaugguucuugccuuuuaccagaaccauccggguguugucuccauagaaacagguaaagcuguccguuacugugggcuugccauauuuuuuggaacuuuuc ...<<<<<.<<<<<.......<<<<..<<<<<.<<<<<<<.....<<<<<<<<....>>>>>>>>..............<<<<<<<<...........>>>>>>>>...>>>>>>>>>>>>......<<<<......>>>>>>>>..>>>>>>>>.>>..................... ...((((((.((((........(((..(((((.(((((((.....((((((((....)))))))).........((...((((((((.(.......).)))))))).))))))))))))))......((((......)))))))...)))))))).))..................... Cryo-EM structure of the yeast B*-b1 complex at an average resolution of 3.86 angstrom; U5 snRNA 6j6n E 103 3.86 RF00026 URS00006184A9_559292 30879786 0030621 0000244,0000353 0005688,0046540 559292 guucgcgaaguaacccuucguggacauuuggucaauuugaaacaauacagagaugaucagcaguuccccugcauaaggaugaaccguuuuacaaagagauuua <<<<<<<<<<.....>>>>>>>>>>.....................................<<<..<<<.....>>>...>>>................... ((((((((((.....)))))))))).....................................(((.((((.....)))..))))................... Cryo-EM structure of the yeast B*-b1 complex at an average resolution of 3.86 angstrom; U6 snRNA 6j6n L 205 3.86 RF00004 URS000023C730_559292 30879786 0045131 0000348 0005686 559292 acgaaucucuuugccuuuuggcuuagaucaaguguaguaucuguucaguguaacaacuaaugaccucagaggcucauauuuguuacaauacacauuuuuuggcacccaaaauaggacgggaagagacuuuuaaagugagacgucgcgacccucgcaggagucguucuugacuuuuuggucgcuugauguuucucucuucccguuc ................................................<<<<<<<<..<..<.<<<<.>>>>.>..>..>>>>>>>>...........................<<<<<<<<<<.<<<<<.>>>>><<<<<<<<<<<<.<<......<<<<<<....>>>>>>...>>>>>>..>>>>>>>>..>>>>>>>>>>. ................................................((((((((.((....((((.))))....)).))))))))..........................(.(((((((((.(((((.)))))((((((((((((.((.......(((((....)))))....))))))..))))))))..))))))))).) Cryo-EM structure of the yeast B*-b1 complex at an average resolution of 3.86 angstrom; U2 snRNA 6j6q B 57 3.7 30879786 559292 gugaucuagaaagguaugucuaaaguuacuuaugcucuuauuuacuaacaaaaucaa ......................................................... ..............(................................)......... Cryo-EM structure of the yeast B*-b2 complex at an average resolution of 3.7 angstrom; UBC4 pre-mRNA 6j6q D 179 3.7 RF00020 URS000053F313_559292 30879786 0000244,0000353 0005682,0046540 559292 aagcagcuuuacagaucaauggcggagggaggucaacaucaagaacugugggccuuugccuauagaacuuauaacgaacaugguucuugccuuuuaccagaaccauccggguguugucuccauagaaacagguaaagcuguccguuacugugggcuugccauauuuuuuggaacuuuuc ...<<<<<<.<<<<.......<<<<..<<<<<.<<<<<<<.....<<<<<<<<....>>>>>>>>..............<<<<<<<<...........>>>>>>>>...>>>>>>>>>>>>......<<<<......>>>>>>>>..>>>>>>>>.>>..................... ...(((((..((((........(((..(((((.(((((((.....((((((((....)))))))).........((...((((((((...........)))))))).))))))))))))))......((((......)))))))...)))).))).))..................... Cryo-EM structure of the yeast B*-b2 complex at an average resolution of 3.7 angstrom; U5 snRNA 6j6q E 103 3.7 RF00026 URS00006184A9_559292 30879786 0030621 0000244,0000353 0005688,0046540 559292 guucgcgaaguaacccuucguggacauuuggucaauuugaaacaauacagagaugaucagcaguuccccugcauaaggaugaaccguuuuacaaagagauuua <<<<<<<<<<.....>>>>>>>>>>.....................................<<<..<<<.....>>>...>>>................... ((((((((((.....)))))))))).....................................(((.((((.....)))..))))................... Cryo-EM structure of the yeast B*-b2 complex at an average resolution of 3.7 angstrom; U6 snRNA 6j6q L 210 3.7 RF00004 URS000023C730_559292 30879786 0045131 0000348 0005686 559292 acgaaucucuuugccuuuuggcuuagaucaaguguaguaucuguucuuuucaguguaacaacuaaugaccucagaggcucauauuuguuacaauacacauuuuuuggcacccaaaauaggacgggaagagacuuuuaaagugagacgucgcgacccucgcaggagucguucuugacuuuuuggucgcuugauguuucucucuucccguuc .....................................................<<<<<<<<..<..<.<<<<.>>>>.>..>..>>>>>>>>...........................<<<<<<<<<<.<<<<<.>>>>><<<<<<<<<<<<.<<......<<<<<<....>>>>>>...>>>>>>..>>>>>>>>..>>>>>>>>>>. .....................................................((((((((.((....((((.))))....)).))))))))..........................(.(((((((((.(((((.)))))((((((((((((.((.......(((((....)))))....))))))..))))))))..))))))))).) Cryo-EM structure of the yeast B*-b2 complex at an average resolution of 3.7 angstrom; U2 snRNA 6jbf A 23 2.6 URS000080DDE4_32630 32630 uugcgucacgccggcgaagucgc ....................... ....................... Crystal structure of the bacterial ribosomal decoding site in complex with 4'-deoxy-4'-fluoro neamine analog (axial 4'-F); RNA (5'-R(*UP*UP*GP*CP*GP*UP*CP*AP*CP*GP*CP*CP*GP*GP*CP*GP*AP*AP*GP*UP*CP*GP*C)-3') 6jbf B 23 2.6 URS000080DDE4_32630 32630 uugcgucacgccggcgaagucgc ....................... ....................... Crystal structure of the bacterial ribosomal decoding site in complex with 4'-deoxy-4'-fluoro neamine analog (axial 4'-F); RNA (5'-R(*UP*UP*GP*CP*GP*UP*CP*AP*CP*GP*CP*CP*GP*GP*CP*GP*AP*AP*GP*UP*CP*GP*C)-3') 6jbf C 23 2.6 URS000080DDE4_32630 32630 uugcgucacgccggcgaagucgc ....................... ....................... Crystal structure of the bacterial ribosomal decoding site in complex with 4'-deoxy-4'-fluoro neamine analog (axial 4'-F); RNA (5'-R(*UP*UP*GP*CP*GP*UP*CP*AP*CP*GP*CP*CP*GP*GP*CP*GP*AP*AP*GP*UP*CP*GP*C)-3') 6jbf D 23 2.6 URS000080DDE4_32630 32630 uugcgucacgccggcgaagucgc ....................... ....................... Crystal structure of the bacterial ribosomal decoding site in complex with 4'-deoxy-4'-fluoro neamine analog (axial 4'-F); RNA (5'-R(*UP*UP*GP*CP*GP*UP*CP*AP*CP*GP*CP*CP*GP*GP*CP*GP*AP*AP*GP*UP*CP*GP*C)-3') 6jbg A 22 3.1 URS0001A16A93_32630 32630 ugcgucacgccggcgaagucgc ...................... ...................... Crystal structure of the bacterial ribosomal decoding site in complex with 4'-deoxy-4'-fluoro neamine analog (equatorial 4'-F); RNA (5'-R(P*UP*GP*CP*GP*UP*CP*AP*CP*GP*CP*CP*GP*GP*CP*GP*AP*AP*GP*UP*CP*GP*C)-3') 6jbg B 22 3.1 URS0001A16A93_32630 32630 ugcgucacgccggcgaagucgc ...................... ...................... Crystal structure of the bacterial ribosomal decoding site in complex with 4'-deoxy-4'-fluoro neamine analog (equatorial 4'-F); RNA (5'-R(P*UP*GP*CP*GP*UP*CP*AP*CP*GP*CP*CP*GP*GP*CP*GP*AP*AP*GP*UP*CP*GP*C)-3') 6jbg C 23 3.1 URS000080DDE4_32630 32630 uugcgucacgccggcgaagucgc ....................... ....................... Crystal structure of the bacterial ribosomal decoding site in complex with 4'-deoxy-4'-fluoro neamine analog (equatorial 4'-F); RNA (5'-R(*UP*UP*GP*CP*GP*UP*CP*AP*CP*GP*CP*CP*GP*GP*CP*GP*AP*AP*GP*UP*CP*GP*C)-3') 6jbg D 23 3.1 URS000080DDE4_32630 32630 uugcgucacgccggcgaagucgc ....................... ....................... Crystal structure of the bacterial ribosomal decoding site in complex with 4'-deoxy-4'-fluoro neamine analog (equatorial 4'-F); RNA (5'-R(*UP*UP*GP*CP*GP*UP*CP*AP*CP*GP*CP*CP*GP*GP*CP*GP*AP*AP*GP*UP*CP*GP*C)-3') 6jjh B 14 1.74 URS0001A16A80_101947 32453431 101947 ggcucggcggcgga .............. .............. Crystal structure of a two-quartet RNA parallel G-quadruplex complexed with the porphyrin TMPyP4; RNA (5'-R(*GP*GP*CP*UP*CP*GP*GP*CP*GP*GP*CP*GP*GP*A)-3') 6jji B 14 3.1 URS0001A16A80_101947 32453431 101947 ggcucggcggcgga .............. .............. Crystal structure of a two-quartet RNA parallel G-quadruplex complexed with the porphyrin TMPyP4 (1:1); RNA (5'-R(*GP*GP*CP*UP*CP*GP*GP*CP*GP*GP*CP*GP*GP*A)-3') 6jq5 A 82 2.059 RF02678 URS0000EEAD20_32630 31088965 0003824 32630 uuacugugagaaucaguaacaaacauguggggcuuauaucuaaucgaaagauuaguauuagugcagacguuaaaaccauguc <<<<<<.......>>>>>>............<<<.<<<.<<<<<<....>>>>>>>>>.>>>.................... ((((((.......))))))...........((((.(((.((((((....))))))))).))).).................. The structure of Hatchet Ribozyme; RNA (82-MER) 6jq5 B 81 2.059 RF02678 URS0000EEAD20_32630 31088965 0003824 32630 uuacugugagaaucaguaacaaacauguggggcuuauaucuaaucgaaagauuaguauuagugcagacguuaaaaccaugu <<<<<<.......>>>>>>............<<<.<<<.<<<<<<....>>>>>>>>>.>>>................... ((((((.......))))))...........((((.(((.((((((....))))))))).))).)................. The structure of Hatchet Ribozyme; RNA (82-MER) 6jq6 U 81 2.626 RF02678 URS0000EEAD29_32630 31088965 0003824 32630 uuacugugagaaucaguaacaaacauguggggcuuauaucuaaucuucggauuaguauuagugcagacguuaaaaccaugu <<<<<<.......>>>>>>...........<<<..<<<.<<<<<<....>>>>>>>>>..>>.>................. ((((((.......))))))...........((((.(((.((((((....))))))))).))).)................. Hatchet Ribozyme Structure soaking with Ir(NH3)6+; RNA (81-MER) 6k0a X 258 4.6 RF00373 URS0000EEAD19_2190 31197137 3.1.26.5 0004526 0008033 0030681 2190 ggagggggcuggugacuuuccccucuuuaagaggggaggaaguuccgcccaccccauuuaugggcagcguccccugagaaggggcgggagaugcagcagaaacgacacggcuccggaagagaugacgaugauagugaaaguugaggacuuccggagaaccggugaaacgggcaucuccccugcccggggugcaagccgguuucggcgcuuagccgaaugucaccgaaauuacagaaggcgggcuauagcccccauuuu <<.<<<<<<<<<<<<<...<<<<<<<...>>>>>>>.....[[.(((((<<<<<<......<<<<<....<<<<<....>>>>>.<<<<<<<<<.............<<<<<<<<<<<.......<...................>..>>>>>>>>..>>>.........>>>>>>>>>.>>>>>>>>>>>...<<<<....>>>>............>>>>>>............)))))]]...>>>>>>>.>>.. ...(((((((((((((...((((((.....)))))).{...[..[[[[[((((((......((((((...(((((....))))).(((((((((.............(((((((((((.....(.(......(.(....).)...).)))))))))..))).........)))))))))))))))))))))...((((....))))............)))))).......}....]]]]].]...)))))))..... cryo-EM structure of an archaeal Ribonuclease P; RPR 6k0a Y 258 4.6 RF00373 URS0000EEAD19_2190 31197137 3.1.26.5 0004526 0008033 0030681 2190 ggagggggcuggugacuuuccccucuuuaagaggggaggaaguuccgcccaccccauuuaugggcagcguccccugagaaggggcgggagaugcagcagaaacgacacggcuccggaagagaugacgaugauagugaaaguugaggacuuccggagaaccggugaaacgggcaucuccccugcccggggugcaagccgguuucggcgcuuagccgaaugucaccgaaauuacagaaggcgggcuauagcccccauuuu <<.<<<<<<<<<<<<<...<<<<<<<...>>>>>>>.....[[.(((((<<<<<<......<<<<<....<<<<<....>>>>>.<<<<<<<<<.............<<<<<<<<<<<.......<...................>..>>>>>>>>..>>>.........>>>>>>>>>.>>>>>>>>>>>...<<<<....>>>>............>>>>>>............)))))]]...>>>>>>>.>>.. ...(((((((((((((...((((((.....)))))).{...[..[[[[[((((((......((((((...(((((....))))).(((((((((.............(((((((((((.....(.(......(.(....).)...).)))))))))..))).........)))))))))))))))))))))...((((....))))............)))))).......}....]]]]].]...)))))))..... cryo-EM structure of an archaeal Ribonuclease P; RPR 6k0b U 83 4.3 RF00005 URS0000EEAD1C_562 31197137 0030533 0006412 562 ggugggguucccgagcggccaaagggagcagacucuaaaucugccgucaucgacuucgaagguucgaauccuucccccaccac <<<<<<<..<<<...........>>>.<<<<<.......>>>>>.<<<...>>>...<<<<<.......>>>>>>>>>>>>.. (((((((..(((...........))).((((.........)))).(((...)))...(((((.......)))))))))))).. cryo-EM structure of archaeal Ribonuclease P with mature tRNA; tRNA 6k0b X 258 4.3 RF00373 URS0000EEAD19_2190 31197137 3.1.26.5 0004526 0008033 0030681 2190 ggagggggcuggugacuuuccccucuuuaagaggggaggaaguuccgcccaccccauuuaugggcagcguccccugagaaggggcgggagaugcagcagaaacgacacggcuccggaagagaugacgaugauagugaaaguugaggacuuccggagaaccggugaaacgggcaucuccccugcccggggugcaagccgguuucggcgcuuagccgaaugucaccgaaauuacagaaggcgggcuauagcccccauuuu <<.<<<<<<<<<<<<<...<<<<<<<...>>>>>>>......[.(((((<<<<<<......<<<<<....<<<<<....>>>>>.<<<<<<<<<.............<<<<<<<<<<<.......<...................>..>>>>>>>>..>>>.........>>>>>>>>>.>>>>>>>>>>>...<<<<....>>>>............>>>>>>............)))))]....>>>>>>>.>>.. ...(((((((((((((...(((((((...))))))).....[..[[[[[((.(((......((((((...(((((....))))).(.(((((((.............(((((((((((.....(.(......(.(....).)...).)))))))))..))).........))))))).)))))))))).))...((((....))))............))))))............]]]]].]...)))))))..... cryo-EM structure of archaeal Ribonuclease P with mature tRNA; RPR 6k0b V 83 4.3 RF00005 URS0000EEAD1C_562 31197137 0030533 0006412 562 ggugggguucccgagcggccaaagggagcagacucuaaaucugccgucaucgacuucgaagguucgaauccuucccccaccac <<<<<<<..<<<...........>>>.<<<<<.......>>>>>.<<<...>>>...<<<<<.......>>>>>>>>>>>>.. (((((((..(((.....[.....))).((((.........)))).(((...)))...(((((..]....)))))))))))).. cryo-EM structure of archaeal Ribonuclease P with mature tRNA; tRNA 6k0b Y 258 4.3 RF00373 URS0000EEAD19_2190 31197137 3.1.26.5 0004526 0008033 0030681 2190 ggagggggcuggugacuuuccccucuuuaagaggggaggaaguuccgcccaccccauuuaugggcagcguccccugagaaggggcgggagaugcagcagaaacgacacggcuccggaagagaugacgaugauagugaaaguugaggacuuccggagaaccggugaaacgggcaucuccccugcccggggugcaagccgguuucggcgcuuagccgaaugucaccgaaauuacagaaggcgggcuauagcccccauuuu <<.<<<<<<<<<<<<<...<<<<<<<...>>>>>>>......[.(((((<<<<<<......<<<<<....<<<<<....>>>>>.<<<<<<<<<.............<<<<<<<<<<<.......<...................>..>>>>>>>>..>>>.........>>>>>>>>>.>>>>>>>>>>>...<<<<....>>>>............>>>>>>............)))))]....>>>>>>>.>>.. ...(((((((((((((...(((((((...))))))).....[..[[[[[((.(((......((((((...(((((....))))).(.(((((((.............(((((((((((.....(.(......(.(....).)...).)))))))))..))).........))))))).)))))))))).))...((((....))))............))))))............]]]]].]...)))))))..... cryo-EM structure of archaeal Ribonuclease P with mature tRNA; RPR 6ke6 3A 175 3.4 RF01846 URS0000B21E09_559292 0006396 0005730 559292 gucgacguacuucauaggaucauuucuauaggaaucgucacucuuugacucuucaaaagagccacugaauccaacuugguugaugagucccauaaccuuuguacccagugagaaauugccguugcuauggcgcgaugaucacccauggguggguacaaauggcagucugacaagu .........................................................................<<<<<.................<<<<<<<<<<..<.........<<<<......>>>>........><<<<..>>>>.>>>>>>>>.>>........>>>>> .........................................................................(((((......(..........(((((((((((.(...(.....(((((....))))).)......)((((..))))))))))))).))....)...))))) 3.4 angstrom cryo-EM structure of yeast 90S small subunit preribosome; U3 snoRNA 6ke6 5A 522 3.4 URS000007769E_559292 559292 ugcgaaagcagugaagacaaguggcuugucguucguuaaaauggccucgucaaacgguggagagagucgcuaggugaucgucagaucugccuagucucuauacagcguguuuaauugacauggguugaugcguauugagagauacaauuugggaagaaauucccagaguguguuucuuuugcguuuaaccugaacagucucaucgugggcaucuugcgauuccauuggugagcagcgaaggauuugguggauuacuagcuaauagcaaucuauuucaaagaauucaaacuugggggaaugccuuguugaauagccggucgcaagacugugauucuucaaguguaaccuccucucaaaucagcgauaucaaacguaccaccgugaaacaccgggguaucuguuugguggaaccugauuagaggaaacucaaagagugcuaugguauggugacggagugcgcuggucaagaguguaaaagcuuuuugaacagagagcauuuccggcagcagagauuucagcugu <<<....>>>..<<<<<<<<<<.>>>>>>>.>>>..............<<<<<<<<.<<...<<<<..<<<<<<<<<<<....>>>>.>>>>>>>>>>>...>>.>>>......>>>>>..<<<<<..........<<<<<<<<<<.<<<<<<<<....>>>>>>>>.>>>>>>>>>>........>>>>>.......<<<<<<<<<<<...........>>>>>.>>>>>>.........................<<<...>>>.........................<<<<<...<<<<<<..<<<<...<<<<<....>>>>>.>.>>>..>>>>.>>..>>>>>.....<<<<<<...<<<<<<<<<<<<<.<<<........>>>>>>>.>.>>>>>>>>....>>>>>>.................................<<<<<<<<.<<<.<<<<<<<<......>>>>.>>>>.>>>...>>>>.>>>>.<<<<.<<<..>>>.>>>>. (((....)))..((((((((((.))))))).)))..............((((.(((.(((..((((..(((((((((((....)))).))))))))))).).)).))).......))))..(((((.....(.(...(((.(.(((.(.((((((....)))))).).))).).)))..).)....))))).....(.((((((((((((.....)....))))).)))))))........................(((...))).........................(((((..(((((((..((((..((((((....))))).)))))..)))).)).)))))).....((((((....((((((((((((.(((........))))))).).))))))).....)))))).................................((((.(((.(((.((((((((......)))).)))).)))...)))..)))).((((.((.().)).)))). 3.4 angstrom cryo-EM structure of yeast 90S small subunit preribosome; 5' ETS 6ke6 SA 1310 3.4 RF01960,RF01959,RF00177 URS0000BC4691_559292 0003735 0005840 559292 agauaguuaucugguugauccugccaguagucauaugcuugucucagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaaggcucauuaaaucaguuaucguuuauuugauaguuccaugguauaacugugguaauucuagagcuaauacaugcuaaucucgacccuuuggaagagauguauuuauuagaucaaugucuucggacucuuugaugaaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggccaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcagaagcucguaguugaacuggcccgguuggccgguccggauuuccaacggggccuugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaacuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcucaacacggggaaacucaccagguccagacacaauaaggauugacauucuugauuuugugggugguggugcauugaugcccuuguucugggccacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauauucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaa ...........................<<<<.<<<<<<...<....<<<.<<...<<....<<....<<..........>>...>>.>>.....<<<.......<<<..<<..<<....<<<..........<....<<<.<<<.....>>>.>>.>....>.......<<<<............>>>>.....<<<<<...<<<<.<........>...>>>>...>>>>>.........<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<.<....<<<....<<<<<<<<.......>>>>>>>>>>>......>.>.....<<...............>>..>>>.<<.<<<..........>>>.>>...<<....>>......>>>>>......<<<....<<<.....>>>..>>>.........>.....<<<<<<<.<<<<<....>>>>>.>>>.>>>>......<<..<...........>..>>.........<<<<<<.......<<<....>>>..................>>>>>>..>>>>>>>>>>..............<.<<...<<<.<<..<<<<<.<<<<<..<.......>..>>>>>.>>>>>....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>..>.>>>>.>>>...>>>...>>.>...............<<...<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>..>>...........................<<.........>>.....<<<<<<<<<<<<..<<.<<<<<<..<<<.<<<<.......................<<......<<<<<.....................>>>>>......<<<........>>>.....>>.......>>>>.>>>.....<<<<<<<............<<<..<<<<....>>>>..>>>............>>>>>>>.......................>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>............>>>>>..<<<<.<<.....<<<<<<<.<<<..<.<<......<<<<<<<...<<.<<<<....>>>>.>>...>>>>>>>......>>.>..>>>.>>>>>>>....>>.>>>>................<<<<<<<<<....>>>>>>>>> ...........................((.(.((((((...(.(..(((..(...((....((.....(..........)....)).)).....(((.......(((..((...(....(((..........((....((.(((.....))).)).....)).......((((............)))).(.(.((((.....(((.(.(....).)...))).....)))).)...).(.((((...(((..).))..)))))...)))...).))..)))..((....((.....((((((((.......)))))))).))......))......(.................)..))).((.(((..........))).))...(.......).....).)))......(((...((((.....))).)))).......).).....(((((((((((((....))))))))).))))....(.((..(...........)..))......)..(((((((......(((....)))...............)..))))))..))))))).))..............(.((...(((.((..(((((.(((((..(...(.)...)))))).)))))....))...(((..((.((...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)).))...))..))).)..)).)..............(((...(((..((((((((.(((........)))))))))))..)))..)).).........................((.........)).....((((((((((((..((..(((((..((((.(((........................(..(...(((((.....................)))))....(.((..........)))..)..).......)))).))).(...(((((((............(((..((((....))))..)))............))))))).........(...)......)..))))).....((((((((.......))))))))......))...))))))).(......)...)))))..((((.((.....((((.(..(((..(.((.........(((..(.((.((..(...).)).)).)..))).........)).)..)))..).))))....)).))))................(((((.(((....))).))))) 3.4 angstrom cryo-EM structure of yeast 90S small subunit preribosome; 18S rRNA 6kuj R 10 3.4 URS0000EEAD27_32630 31209309 32630 uccuugcuac .......... .......... Structure of influenza D virus polymerase bound to cRNA promoter in class 1; 3'-cRNA promoter 6kuj V 13 3.4 URS000197CF50_32630 31209309 32630 agcauaagcagga .<<....>>.... .((....)).... Structure of influenza D virus polymerase bound to cRNA promoter in class 1; 5'-cRNA promoter 6kuk V 15 3.9 URS0000EEAD24_32630 31209309,31209309 32630 agcaguagcaaggag .<<....>>...... .((....))...... Structure of influenza D virus polymerase bound to vRNA promoter in mode A conformation (class A1); 5'-vRNA 6kup V 15 4.3 URS0000EEAD24_32630 31209309,31209309 32630 agcaguagcaaggag .<<....>>...... .((....))...... Structure of influenza D virus polymerase bound to vRNA promoter in Mode A conformation(Class A2); 5'-vRNA 6kur R 13 3.7 URS0000EEACFF_32630 31209309,31209309 32630 cuccugcuuaugc ............. ............. Structure of influenza D virus polymerase bound to vRNA promoter in Mode B conformation (Class B1); 3'-vRNA 6kur V 15 3.7 URS0000EEAD24_32630 31209309,31209309 32630 agcaguagcaaggag .<<....>>...... .((....))...... Structure of influenza D virus polymerase bound to vRNA promoter in Mode B conformation (Class B1); 5'-vRNA 6kut R 12 4.1 URS0000EEACFF_32630 31209309,31209309 32630 cuccugcuuaug ............ ............ Structure of influenza D virus polymerase bound to vRNA promoter in Mode B conformation (Class B2); 3'-vRNA 6kut V 15 4.1 URS0000EEAD24_32630 31209309,31209309 32630 agcaguagcaaggag .<<....>>...... .((....))...... Structure of influenza D virus polymerase bound to vRNA promoter in Mode B conformation (Class B2); 5'-vRNA 6kuu R 12 4.0 URS0000EEACFF_32630 31209309 32630 cuccugcuuaug ............ ............ Structure of influenza D virus polymerase bound to vRNA promoter in Mode B conformation (Class B3); 3'-vRNA 6kuu V 15 4.0 URS0000EEAD24_32630 31209309 32630 agcaguagcaaggag .<<....>>...... .((....))...... Structure of influenza D virus polymerase bound to vRNA promoter in Mode B conformation (Class B3); 5'-vRNA 6kuv R 10 4.1 URS0000EEAD27_32630 31209309,31209309 32630 uccuugcuac .......... .......... Structure of influenza D virus polymerase bound to cRNA promoter in class 2; 3'-cRNA 6kuv V 13 4.1 URS0000EEACF8_32630 31209309,31209309 32630 agcauaagcagga .<<....>>.... .((....)).... Structure of influenza D virus polymerase bound to cRNA promoter in class 2; 5'-cRNA 6kwq B 31 1.76 URS0001A16A92_32630 31863580 32630 gggagaugaaagucuccaggucucucggaaa .<<<<<<....>>>>>>.............. .((((((....)))))).............. Crystal structure of enterovirus 71 polymerase elongation complex (native form); RNA (31-MER) 6kwq C 11 1.76 URS000080E152_32630 31863580 32630 guuccgagaga ........... ........... Crystal structure of enterovirus 71 polymerase elongation complex (native form); RNA (5'-R(*UP*GP*UP*UP*CP*CP*GP*AP*GP*AP*GP*A)-3') 6kwr B 28 2.5 URS0001A16A92_32630 31863580 32630 gggagaugagucuccaggucucucggaa .<<<<<<..>>>>>>............. .((((((..))))))............. Crystal structure of enterovirus 71 polymerase elongation complex (ddCTP form); RNA (31-MER) 6l0y A 22 3.0 URS00021ED999_32630 32630 gguagacgcuucggcguuugcc ...................... ...................... Structure of dsRNA with G-U wobble base pairs; RNA (5'-R(*GP*GP*UP*AP*GP*AP*CP*GP*CP*UP*UP*CP*GP*GP*CP*GP*UP*UP*UP*GP*CP*C)-3') 6l0y B 22 3.0 URS00021ED999_32630 32630 gguagacgcuucggcguuugcc ...................... ...................... Structure of dsRNA with G-U wobble base pairs; RNA (5'-R(*GP*GP*UP*AP*GP*AP*CP*GP*CP*UP*UP*CP*GP*GP*CP*GP*UP*UP*UP*GP*CP*C)-3') 6lkq s 1532 3.1 RF00177,RF01959,RF01960 URS0001A24B52_562 32341159 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggauc .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<.<<..>>.>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<.<.......>>>.>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<.......>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<........<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>......>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<..<.<<<<<<<........>>>>>>>>...>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((((((((..)))))))).)))))..)))))......(((......(((((((..((...(.(((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..(......))))))).))))).)..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(..(.(((.((..........))..))).)...)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((....(((((((....(((((((...((........))......)))))))....).......((....)).))))))...)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((((.......)))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((...((((..(.........(........)...........(((((((.......((.(((..(((((((....)))))))...((....))..))).).)...((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((...((.....)).))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))......)..))))..(....((((((.....(((..((...(((....)))...))....))).....)))))).......(....(((((((........)))))))....)..)..))))).....(.(((((.........))))).)......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... The Structural Basis for Inhibition of Ribosomal Translocation by Viomycin; 16S ribosomal RNA 6lkq t 2850 3.1 RF02540,RF02541 URS000080E25C_562 32341159 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaaggggguacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugaugaaguguggacgccagucugcaugcuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu 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.(((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(..((..))...)...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.((((..(.(...((.........))...).).......................))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((..(....)..))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...(((.(.(.((((.((.....)))))).).)...)))...))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(.((.....)).)...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((..(.......(................)......)..)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..((((.......))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..)..))))))).. The Structural Basis for Inhibition of Ribosomal Translocation by Viomycin; 23S ribosomal RNA 6lkq u 118 3.1 RF00001 URS0000366A67_562 32341159 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (((((((((.....((((((((....((.((((...(.....)...))))...))...)))))).)).((.......((((((((...)))))))).......))...))))))))). The Structural Basis for Inhibition of Ribosomal Translocation by Viomycin; 5S ribosomal RNA 6lqm 2 3532 3.09 RF02543,RF02540 URS0000E60B81_9606 32669547 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugagnccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaanggaaaguugaaaagaacuuugaagngagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcggcccggcggaucuuucccgcgcgggggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcunggaaggcccggcggggaagguggcucgggggcccccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcncucuccccccucccggcgcgccggggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccgggggaggccacgcgcgcgucccccgaagagggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccnucuugnaacncggaccaaggagucuaacacgngcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgagggngcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuagnacccnanagauggugancuaugccugggcagggcgaagccagaggaaacucuggugnagguccguagcgguccugacgugcaaaucgnucguccgaccuggguauagnggcgaaagacuaaucgaaccaucuaguagcuggnucccuccgaaguuucccucaggauagcuggcgcucucgcagacccgacgcccgccacgcaguuuuauccgguaaagcgaaugauuagaggccuauucucaaacuuuaaaungguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacnuuuggnaagcngaacuggcgcuncgggaugaaccgaacgccggguuaangcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcccgaaucaacuagcccugaaaauggaugncgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagcggcggcccggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcgnugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguagunnnaaauauucaaacganaacuuugaaggccgaaguggngaaggguuccaugugaacagnanuugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucgnguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccggggnagaggguguaaaucucgcnccgggccguaccnauauccgcagcaggucuncaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagcnggauccguaacuucgggauaaggauuggcucuaagggcuggagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugccnagugcucugaaugucanagugnagaaauucaaugaagcgcggguaaacggcgguuaagguagcnaanugccucnucaucuaauuagugacgcgcaugaauggaugancgagauucccacugucccuaccuacuauccagcgaaaccacngncaagggaacgngcuuggnggaaucagcngngaaagaaganccuguugagcuugacucuagucuggcacggugaaguuuucacugacccggngaggcgggggggcgagccccgaggggcucucgcuucuggcgccaancgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccaggugggnaguuugacngnggcgguacaccugucaaacgguancgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucungauuuucagnacgaauacagaccgugaaagcggggccunacgauccuucugaccuuuungguuuuaagcaggannugucagaaaaguuaccacagggauaacuggcuuguggcggccangcguucauagcgacgucgcuuuuugauccuungaugucggcucuuccuaucauugunaagcagaauunaccaagcguungauuguucacccacuaauagggaacgugngcuggnnuuagancgucgugagacagnuuaguuuuacccuncugaugnuguguuguugccaugguaauccugcncaguacgagaggaaccgcagguncanacauuugguguaunugcuuggcugaggagccaauggggcgaagcuacnaucugugggauuaugacunaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccggucccccgccgggguccgguncngagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>>..<<<<<<<<<<...<<<<.<<<........<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>...>>>.>>>>..>>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<......>>>..................................<<<<<<<<..<<<.<....<<<<<<<<.<<<.....<<<<<<<<<<<..<<<<<<<..<..........<<<<.<<<..<<<....>>>>>>>>>>.....>..>>>>...>>>>>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<.<<<<<<<<<<<<<<<...<<..<<<....<<<<......<<<<<<......>>>>>>.......>>>>...>>>........>>>>>>..>>>>>>>>>>>....................<<<<<<.<<<<<<..............>>>>>>.<<<<<<.<<<<.<<<<<<<<<<..<<<...<<<<..................>>>>...>>>...>>>>>>>.>>>...>>>>..>>>>.>>..<<<<<<<<<<.....>>>>>>>>.>>....>>>>>>......>>.>>>>>....>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<......>>>>>>>..<<<<<...<<<..<<<..(((...[[.>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<......................<<<.<<<<<<<<<...<<<....<<...<.<<..>>.>...>>..>.>>...>>>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.............>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<...........]]...)))............................>>>>>>>>>....>>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<...<...>...>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<...<<<<<<<....>>>>>>>...<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<<<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>.>.>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<..>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>>..........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<.>>>>>>...<<<<<.....<<<<..<.....<<.....>>....>...............<<<<<<<<<<<.....>>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>><<<<....>>>>>>)))].....<<<<<<<..<<<..)))))).>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<.]]]..>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.....<<<<<<<.<<..<<<<....<<<........<<<<<.<<<<....>>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>..............>>>>..>>>>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<.<..<<<<........>>>>..>>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((...((((((((((.....)))))).)))).....)))....(((((((((....(((.((((...(....((((((((..({((((......)))))....[[(...).(((....}]])))...).))))))))..))).))))...)))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....(((((((((((..(((((((.(.....(......(((.((....(......)..)))))..).....)))))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((..(.((((......(.(((........))).).......))))..))))........))))))..)))))))))))....................((((((.(((((((............))))))).((((((.((((.(((((((((((.((....((((..................))))....)).).))))))).)))...))))..)))).))..(((((((.((.....)).))))).))..[.)))))).....))).)))))...)))))...)))))))).<((((........))))((((((....(((((((((((((..(((..(((((........))))..)..)))...((....))...(((((.(......).)))))..(((((...(((..(((..[......[[)))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((......................(((.((((((((....(((....(((..(.((())).)..)))..)).)....))))))...(((((((((.(......))))))))))....))))))))))))..))..((((..((((.....))))..))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.....{.......)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((..........]]......]]...........................)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...(.....(((....)))..........((.(((((...(...)...))))))).......)....))...(((((........)))))]]((((....(((((...(((((((....)))))))..((((....)))...(...((((((...(((((((((((((((((((((((..{{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....(((((((.......))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.((((((((((..))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(...(......(((......)))......).)))))..)))))..........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.(.......((((.((((((..(((((.(((((((((.((((((.))))))...(((((.....((((.....................................(((((.((((.......)))).)))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(..((..((((....{..))))..)).)(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......(....(..(((((...((.......))...)))))....)....).......(((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).))....(((((((....))).))))..a..)..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}}.)))))..)).))...))))...)))).(((....((((.....}.......))))....)))..)))...).)))))).....((((((..((..((((.(..(((........(((((.(.((....).)).))))).......)))...(((...((.....((((.(((((((......)))))))))))....))...)))...........)..))))..)).))))))(((((.(..(.......)..)....((.(((((((.((.....((((.(..(((((......)))))..)))))....))....)))).))).))..))))).. Cryo-EM structure of a pre-60S ribosomal subunit - state C; 28S rRNA 6lqm 5 120 3.09 RF00001 URS000002B0D5_9606 32669547 0003735 0005840 9606 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. Cryo-EM structure of a pre-60S ribosomal subunit - state C; 5S rRNA 6lqm 8 156 3.09 RF00002 URS00004B2C76_9606 32669547 0003735 0005840 9606 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<<<<....>>>>.....<.<<<......>>.............>>>..>...>>>....<<....>><<<<<<<<.......>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))((((((((.......)))))))).................... Cryo-EM structure of a pre-60S ribosomal subunit - state C; 5.8S rRNA 6lqp 3A 175 3.2 RF01846 URS0000B21E09_559292 32943522 0006396 0005730 559292 gucgacguacuucauaggaucauuucuauaggaaucgucacucuuugacucuucaaaagagccacugaauccaacuugguugaugagucccauaaccuuuguacccagugagaaauugccguugcuauggcgcgaugaucacccauggguggguacaaauggcagucugacaagu .........................................................................<<<<<.................<<<<<<<<<<..<.........<<<<......>>>>.......>.<<<<..>>>>.>>>>>>>>.>>........>>>>> .........................................................................(((((......(..........(((((((((((.(...(.....((((......)))).)......)((((..))))))))))))).))....)...))))) Cryo-EM structure of 90S small subunit preribosomes in transition states (State A); U3 snoRNA 6lqp 5A 523 3.2 URS000007769E_559292 32943522 559292 ugcgaaagcaguugaagacaaguggcuugucguucguuaaaauggccucgucaaacgguggagagagucgcuaggugaucgucagaucugccuagucucuauacagcguguuuaauugacauggguugaugcguauugagagauacaauuugggaagaaauucccagaguguguuucuuuugcguuuaaccugaacagucucaucgugggcaucuugcgauuccauuggugagcagcgaaggauuugguggauuacuagcuaauagcaaucuauuucaaagaauucaaacuugggggaaugccuuguugaauagccggucgcaagacugugauucuucaaguguaaccuccucucaaaucagcgauaucaaacguaccaccgugaaacaccgggguaucuguuugguggaaccugauuagaggaaacucaaagagugcuaugguauggugacggagugcgcuggucaagaguguaaaagcuuuuugaacagagagcauuuccggcagcagagauuucagcugu <<<....>>>...<<<<<<<<<<.>>>>>>>.>>>..............<<<<<<<<.<<...<<<<..<<<<<<<<<<<....>>>>.>>>>>>>>>>>...>>.>>>......>>>>>..<<<<<..........<<<<<<<<<<.<<<<<<<<....>>>>>>>.>>>>>>>>>>>........>>>>>.......<<<<<<<<<<<...........>>>>>.>>>>>>.........................<<<...>>>.........................<<<<<..<<<<<<<..<<<<...<<<<<....>>>>>.>.>>>..>>>>.>>.>>>>>>.....<<<<<<...<<<<<<<<<<<<<.<<<........>>>>>>>.>.>>>>>>>>....>>>>>>.................................<<<<.<<<.<<<.<<<<<<<<......>>>>.>>>>.>>>...>>>..>>>><<<<<.<<<..>>>.>>>>> (((....)))...((((((((((.))))))).)))..............((((((((.(((..((((..(((((((((((....)))).))))))))))).).)).)))......)))))..(((((.....(.(...((((((..(.((((((((....)))))))).)..))))))..).)....))))).....(.((((((((((((.....)....))))).)))))))........................(((...))).........................(((((..(((((((..((((..((((((....))))).)))))..)))).)).)))))).....((((((....((((((((((((.(((........))))))).).))))))).....)))))).................................((((.(((.(((.((((((((......)))).)))).)))...)))..)))).((((.((.().)).)))). Cryo-EM structure of 90S small subunit preribosomes in transition states (State A); 5' ETS 6lqp SA 1325 3.2 RF01960,RF01959,RF00177 URS00021ED968_559292 32943522 0003735 0005840 559292 aagauaguuaucugguugauccugccaguagucauaugcuugucucagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaaggcucauuaaaucaguuaucguuuauuugauaguuccaugguauaacugugguaauucuagagcuaauacaugcuaaucucgacccuuuggaagagauguauuuauuagaucaaugucuucggacucuuugaugaaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggccaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcagaagcucguaguugaacuggcccgguuggccgguccggauuuccaacggggccuugguucucuaggacugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaacuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcucaacacggggaaacucaccagguccagacacaauaaggauugacauucuugauuuugugggugguggugcauugaugcccuuguucugggccacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauauucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaa ............................<<<<.<<<<<<........<<<.<<...<<....<<....<<..........>>...>>.>>.....<<<.......<<<..<<..<<....<<<..........<.....<<.<<.......>>.>>......>.......<<<<............>>>>.....<<<<<...<<<<..............>>>>...>>>>>.........<<<<...<<.....>>..>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>.....<<...............>>..>>>.<<.<<<..........>>>.>>.<.<<....>>.>....>>>>>......<<<....<<<.....>>>..>>>...............<<<<<<<.<<<<<....>>>>>.>>>.>>>>......<<..<...........>..>>.........<<<<<<.......<<<....>>>..................>>>>>>..>>>>>>>>>>.........<....<.<<...<<<.<<..<<<<<.<<<<<..<.......>..>>>>>.>>>>>....<.....>.......>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>...............<<...<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>..>>......>....................<<.........>>.....<<<<<<<<<<<<..<<.<<<<<<..<<<.<<<<.......................<<.<....<<<<<........<.....>......>>>>>......<<<........>>>...>.>>.......>>>>.>>>.....<<<<<<<............<<<..<<<<....>>>>..>>>............>>>>>>>.......................>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>............>>>>>..<<<<.<<.....<<<<<<<.<<<..<.<<......<<<<<<<...<<.<<<......>>>.>>...>>>>>>>......>>.>..>>>.>>>>>>>....>>.>>>>................<<<<<<<<<....>>>>>>>>> ............................((((.((((((...(.(..(((..(...((....((.....(..........)....)).)).....(((.......(((..((...(....(((..........(.....((.(.(.....).).))......).......((((............)))).(.(.((((.....((..(.(....).)....)).....)))).)...).(.((((...(((..).))..)))))...)))...).))..)))..((....((.....((((((((.......)))))))).))......).).....(.................)..))).((.(((..........))).))...(.......).....).)))......(((...((((.....))).)))).......).).....(((((((((((((....))))))))).))))....(.((..(...........)..))......)..(((((((......(((....)))...............)..))))))..))))))))))..............(.((...(((.((..(.(((.(((((......(.)....))))).))).)....(.....).......))...(((.(((.((...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)).)))..))..))).)..)).)..............(((...(((..((((((((.(((........)))))))))))..)))..)).).........................((.........)).....((((((((((((..((..(((((..((((.(((.......................(...(...(((((.....................)))))....(.((..........)))..)..).......)))).))).(...(((((((............(((..((((....))))..)))............))))))).........(...)......)..))))).....((((((((.......))))))))......))...))))))).(......)...)))))..((((.((.....((((((..(((..(.((........(((((.(.((.((..(...).)).)).).)))).).......)).)..)))..))))))....)).))))................(((((((((....))))))))) Cryo-EM structure of 90S small subunit preribosomes in transition states (State A); 18S pre-rRNA 6lqq 3A 175 4.1 RF01846 URS0000B21E09_559292 32943522 0006396 0005730 559292 gucgacguacuucauaggaucauuucuauaggaaucgucacucuuugacucuucaaaagagccacugaauccaacuugguugaugagucccauaaccuuuguacccagugagaaauugccguugcuauggcgcgaugaucacccauggguggguacaaauggcagucugacaagu .........................................................................<<<<<.................<<<<<<<<<<..<.........<<<<......>>>>.......>.<<<<..>>>>.>>>>>>>>.>>........>>>>> .........................................................................(((((......(..........(((((((((((.(...(.....((((......)))).)......)((((..))))))))))))).))....)...))))) Cryo-EM structure of 90S small subunit preribosomes in transition states (State B); U3 snoRNA 6lqq 5A 375 4.1 URS000007769E_559292 32943522 559292 ugcgaaagcaguugaagacaaguggcuugucguucguuaaaauggccucgucaaacggugguacagcguguuuaauugacauggguugauaaccugaacagucucaucguggccauuggugagcagcgaaggauuugguggauuacuagcuaauagcaaucuauuucaaagaauucaaacuugggggaaugccuuguugaauagccggucgcaagacugugauucuucaaguguaaccuccucucuaucaaacguaccgguaucuguuuggugggaaacucaaagagugcuaugguauggugacggagugcgcuggucaagaguguaaaagcuuuuugaacagagagcauuuccggcagcagagauuucagcugu <<<....>>>...<<<<<<<<<<.>>>>>>>.>>>..............<<<<<<<<.<<...>>.>>>......>>>>>..<<<<<<.>>>>>>.......<<<<<<<<<..>>>.>>>>>>.........................<<<...>>>.........................<<<<<..<<<<<<<..<<<<...<<<<<....>>>>>.>.>>>..>>>>.>>.>>>>>>....<<<<<<<<<<<<..>>>.>.>>>>>>>>..............................<<<<.<<<.<<<.<<<<<<<<......>>>>.>>>>.>>>...>>>..>>>><<<<<.<<<..>>>.>>>>> (((....)))...((((((((((.))))))).)))..............((((((((.((().)).)))......)))))..(((((...))))).....(.(((((((((()))).)))))))........................(((...))).........................(((((..(((((((..((((..((((((....))))).)))))..)))).)).)))))).....(((((((((((()))).).)))))))...............................((((.(((.(((.((((((((......)))).)))).)))...)))..)))).((((.((.().)).)))). Cryo-EM structure of 90S small subunit preribosomes in transition states (State B); 5' ETS 6lqq SA 1323 4.1 RF01960,RF01959,RF00177 URS00021ED968_559292 32943522 0003735 0005840 559292 aagauaguuaucugguugauccugccaguagucauaugcuugucucagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaaggcucauuaaaucaguuaucguuuauuugauaguuccaugguauaacugugguaauucuagagcuaauacaugcuaaucucgacccuuuggaagagauguauuuauuagaucaaugucuucggacucuuugaugaaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggccaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcagaagcucguaguugaacuggcccgguuggccgguccggauuuccaacggggccuugguucuauuuucuaggacugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaacuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcucaacacggggaaacucaccagguccagacacaauaaggauugacauucuugauuuugugggugguggugcauugaugcccuuguucugggccacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggcaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaa ............................<<<<.<<<<<<........<<<.<<...<<....<<....<<..........>>...>>.>>.....<<<.......<<<..<<..<<....<<<..........<.....<<.<<.......>>.>>......>.......<<<<............>>>>.....<<<<<...<<<<..............>>>>...>>>>>.........<<<<...<<.....>>..>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>.....<<...............>>..>>>.<<.<<<..........>>>.>>.<.<<....>>.>....>>>>>......<<<....<<<.....>>>..>>>...............<<<<<<<.<<<<<....>>>>>.>>>.>>>>......<<..<...........>..>>.........<<<<<<.......<<<....>>>..................>>>>>>..>>>>>>>>>>.........<....<.<<...<<<.<<..<<<<<.<<<<<..<.......>..>>>>>.>>>>>.<..<<..<...>..>>.>....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>...............<<...<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>..>>......>....................<<.........>>.....<<<<<<<<<<<<..<<.<<<<<<..<<<.<<<<.......................<<.<....<<<<<........<.....>......>>>>>......<<<........>>>...>.>>.......>>>>.>>>.....<<<<<<<............<<<..<<<<....>>>>..>>>............>>>>>>>................>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>............>>>>>..<<<<.<<.....<<<<<<<.<<<..<.<<......<<<<<<<...<<.<<<......>>>.>>...>>>>>>>......>>.>..>>>.>>>>>>>....>>.>>>>................<<<<<<<<<....>>>>>>>>> ............................((((.((((((...(.(..(((..(...((....((.....(..........)....)).)).....(((.......(((..((...(....(((..........(.....((.(.(.....).).))......).......((((............)))).(.(.((((.....((..(.(....).)....)).....)))).)...).(.((((...(((..).))..)))))...)))...).))..)))..((....((.....((((((((.......)))))))).))......).).....(.................)..))).((.(((..........))).))...(.......).....).)))......(((...((((.....))).)))).......).).....(((((((((((((....))))))))).))))....(.((..(...........)..))......)..(((((((......(((....)))...............)..))))))..))))))))))..............(.((...(((.((..(.(((.(((((......(.)....))))).))).).....(.........).......))...(((.(((.((...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)).)))..))..))).)..)).)..............(((...(((..((((((((.(((........)))))))))))..)))..)).).........................((.........)).....((((((((((((..((..(((((..((((.(((.......................(...(...(((((.....................)))))....(.((..........)))..)..).......)))).))).(...(((((((............(((..((((....))))..)))............))))))).............)..))))).....((((((((.......))))))))......))...))))))).(......)...)))))..((((.((.....((((((..(((..(.((........(((((.(.((.((..(...).)).)).).)))).).......)).)..)))..))))))....)).))))................(((((((((....))))))))) Cryo-EM structure of 90S small subunit preribosomes in transition states (State B); 18S pre-rRNA 6lqr 3A 175 8.6 RF01846 URS0000B21E09_559292 32943522 0006396 0005730 559292 gucgacguacuucauaggaucauuucuauaggaaucgucacucuuugacucuucaaaagagccacugaauccaacuugguugaugagucccauaaccuuuguacccagugagaaauugccguugcuauggcgcgaugaucacccauggguggguacaaauggcagucugacaagu .........................................................................<<<<<.................<<<<<<<<<<..<.........<<<<......>>>>........><<<<..>>>>.>>>>>>>>.>>........>>>>> .........................................................................(((((......(..........(.(.(((((((.(...(.....((((......)))).)......)((((..))))))))))).)..)....)...))))) Cryo-EM structure of 90S small subunit preribosomes in transition states (State C); U3 snoRNA 6lqr 5A 192 8.6 URS000007769E_559292 32943522 559292 ugcgaaagcaguugaagacaaguggcuugucguucguuaauggccucguccagcgaaggauuugguggauuacuagcuaauagcaaucuaggaaacucaaagagugcuaugguauggugacggagugcgcuggucaagaguguaaaagcuuuuugaacagagagcauuuccggcagcagagauuucagcugu <<<....>>>...<<<<<<<<<<.>>>>>>>.>>>........................................<<<...>>>....................................<<<<.<<<.<<<.<<<<<<<<......>>>>.>>>>.>>>...>>>..>>>><<<<<.<<<..>>>.>>>>> (((....)))...((((((((((.))))))).)))........................................(((...)))....................................((((.(((.(((.((((((((......)))).)))).)))...)))..)))).((((.((.().)).)))). Cryo-EM structure of 90S small subunit preribosomes in transition states (State C); 5' ETS 6lqr SA 1283 8.6 RF01960,RF01959,RF00177 URS00021ED94D_559292 32943522 0003735 0005840 559292 aagauaguuaucugguugauccugccaguagucauaugcuugucucagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaaggcucauuaaaucaguuaucguuuauuugauaguuccaugguauaacugugguaauucuagagcuaauacaugcuaaucucgacccuuuggaagagauguauuuauuagaucaaugucuucggacucuuugaugaaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggccaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcagaagcucguaguugaacuggcccgguuggccgguccggauuuccaacggggccuugguucuauuuucuaggacugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagacuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcucaacacggggaaacucaccagguccagacacaauaaggauugacauucuugauuuugugggugguggugcauugaugcccuuguucugggccacgcgcgcuacacugacggagccagcgagucuagugaaacuccgucgugcuggcaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagugguuuccguaggugaaccugcggaaggaucauuaa ............................<<<<.<<<<<<........<<<.<<...<<....<<....<<..........>>...>>.>>.....<<<.......<<<..<<..<<....<<<..........<.....<<.<<.......>>.>>......>.......<<<<............>>>>.....<<<<<...<<<<..............>>>>...>>>>>.........<<<<...<<.....>>..>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>.....<<...............>>..>>>.<<.<<<..........>>>.>>.<.<<....>>.>....>>>>>......<<<....<<<.....>>>..>>>...............<<<<<<<.<<<<<....>>>>>.>>>.>>>>......<<..<...........>..>>.........<<<<<<.......<<<....>>>..................>>>>>>..>>>>>>>>>>.........<....<.<<...<<<.<<..<<<<<.<<<<<..<.......>..>>>>>.>>>>>.<..<<..<...>..>>.>....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>..<<...<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>..>>.....>....................<<.........>>.....<<<<<<<<<<<<..<<.<<<<<<..<<<.<<<<.......................<<.<....<<<<<........<.....>......>>>>>......<<<........>>>...>.>>.......>>>>.>>>.....<<<<<<<..................>>>>>>>................>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>............>>>>>..<<<<.<<.....<<<<<<<.<<<..<.<<......<<<<<<<...<<.<<<......>>>.>>...>>>>>>>......>>.>..>>>.>>>>>>>....>>.>>>>........<<<<<<<<<....>>>>>>>>>.......... ............................((((.((((((...(.(..(((..(...((....((.....(..........)....)).)).....(((.......(((..((...(....(((..........(.....((.(.(.....).).))......).......((((............)))).(.(.((((.....((..(.(....).)....)).....)))).)...).(.((((...(((..).))..)))))...)))...).))..)))..((....((.....((((((((.......)))))))).))......).).....(.................)..))).((.(((..........))).))...(.......).....).)))......(((...((((.....))).)))).......).).....(((((((((((((....))))))))).))))....(.((..(...........)..))......)..(((((((......(((....)))...............)..))))))..))))))))))..............(.((...(((.((..(.(((.(((((......(.)....))))).))).).....(.........).......))...(((.(((.((...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)).)))..))..))).)..)).).(((...(((..((((((((.(((........)))))))))))..)))..)).)........................((.........)).....((((((((((((..((..(((((..((((.(((.......................(...(...(((((.....................)))))....(.((..........)))..)..).......)))).))).(...(((((((..................))))))).............)..))))).....((((((((.......))))))))......))...))))))).(......)...)))))..((((.((.....((((((..(((..(.((........(((((.(.((.((..(...).)).)).).)))).).......)).)..)))..))))))....)).))))........((((((((......)))))))).......... Cryo-EM structure of 90S small subunit preribosomes in transition states (State C); 18S pre-rRNA 6lqs 3A 234 3.8 RF01846 URS0000B21E09_559292 32943522 0006396 0005730 559292 gucgacguacuucauaggaucauuucuauaggaaucgucacucuuugacucuucaaaagagccacugaauccaacuugguugaugagucccauaaccuuuguaccccagagugagaaauagcuuggccgaaucgguucggccacuauauugccguugcauuuuauggcgcgaugaucuugacccauccuaucuucgaagauagggggguggguacaaauggcagucugacaagu .........................................................................<<<<<.................<<<<<<<..<<....<............<<<<<<<<<..>>>>>>>>>.......<<<............>>>........>...<<<..<<<<<<<<<..>>>>>>>>>.>>>.>>.>>>>>.>>........>>>>> .........................................................................(((((......(..........((((((....(....(...(...((...(((((((((())))))))))...))..(((.....().....))).)......).........((((((((()))))))))......)...)))).))....)...))))) Cryo-EM structure of 90S small subunit preribosomes in transition states (State D); U3 snoRNA 6lqs 5A 152 3.8 URS000007769E_559292 32943522 559292 ugcgaaagcaguugaagacaaguggcuugucguucguuaauggccucgcagcgaaggauuugguggauuacuagcuaauagcaaucuaggaaacucaaagagugcuaugcggagugcgcgagagcauuuccggcagcagagauuucagcugu <<<....>>>...<<<<<<<<<...>>>>>>.>>>......................................<<<...>>>...........................<<<<<<<<......>>>>.>>>>.<<<<.<<<..>>>.>>>>. (((....)))...((((((((((.))))))).)))......................................(((...)))...........................((((((((.()...)))).)))).((((.((....)).)))). Cryo-EM structure of 90S small subunit preribosomes in transition states (State D); 5' ETS 6lqs SA 1249 3.8 RF01960,RF01959,RF00177 URS00021ED94D_559292 32943522 0003735 0005840 559292 aagauaguuaucugguugauccugccaguagucauaugcuugucucaaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaaucaguuaucguuuauuugauagcaugguauaacugugguaauucuagagcuaauacaugcuaaucucgacccuuuggaagagauguauuuauuagagucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggggcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauugcucguaguugaacuuugggcccgguuggccgguccggauuuccaacggggccuuuccuuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauagguugguucuauuucuaggaccugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacguagggaucgggugguguuuuuuuaaugacccacucggcaccuugggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcucaacacggggaaacucaccagguccagacacaauaaggauugacauucuugauuuugugggugguggugcauugaugcccuuguucugggcccgcgcgcuacacugacggagccagcgaguaacuccgucgugcugacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaaggguuuccguaggugaaccugcggaaggaucauuaa ..............................<..<<<<<<...<......<<<.<<<..<<....<<....<<..........>>...>>.>>....<<<..<<..<<....<<<.......<<....<<.<<<.....>>>.>>.....>>......<<<<<..<<....>>..>>>>><...<<<<<<..<<<<..>>>>....<<......>>>>>>>>.....>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>..<<....<<.....<<<<<<<<.......>>>>>>>>.>>......>>.>>>>>>.........<<<....<<<.....>>>..>>>.........>.....<<<<<<<..<<<<....>>>>..>>>>.>>>......<<..<...........>..>>.........<<<<<<.......<<<....>>>..................>>>>>>..>>>>>>.>.<.<<...<<<.<<.....<<<<<.<<<<<..<.<...>.>..>>>>>.>>>>>........<<<<<.<<............<.......>...<<.....>>.............>>.>>..>>>..........<..<...<..>..>..>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>..>.>>>>.>>>...>>>...>>.>..<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>.....................<<.........>>.....<<<<<<<<<<<<..<<.<<<<<<..<<<.<<<<......................<<<......<<<<<.....................>>>>>.......<<........>>......>>>.....>>>>.>>>.....<<<<<<<...........>>>>>>>.............>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>............>>>>>..<<<<.<<....<.<<<<.<..<<..<.<<......<<...<<......<<<<....>>>>......>>...>>......>>.>..>>..>.>>>>>....>>.>>>>.......<<<<<<<<<....>>>>>>>>>.......... ..............................((.((((((...(.(....(((.(((..((....((.....(..........)....))[))....(((..((..((....(((.......((....((.(((.....))).)).....))......(((((..((....))..)))))(.(.((((((..(((....))).....(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..)))..((....((.....((((((((.......)))))))).))......)).)))))).......(.(((...((((.]...))).)))))......).).....((.((((...(((....)))...))))..))....(.(.(.(...........))..)......)..(((((((......(((....)))...............)..))))))..)))))))).(.((...(((.(......(.(((.(((((..(..(..).)..))))).))).)...(....((((..((............(.......)...((.....)).............))..)..)))........).(..(.........)..)......)...((...((.((...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)).))....)..))).)..)).)..(((..((((((((.(((........)))))))))))..))).....................((.........)).....((((((((((((..((..(((((..(((..(((.......................(...(...(((((.(.....(.)..........))))))......((..........).)..)..)......)))..))).(...(((((((...........)))))))..........)..))))).....((((((((.......))))))))......))...))))))).(......)...)))))..((((.((....((.((((...((..(.((.......((..(..(.(..((.(....).))..).)..)...).).....)).)..))...))))))....)).)))).......((((((((......)))))))).......... Cryo-EM structure of 90S small subunit preribosomes in transition states (State D); 18S pre-rRNA 6lqt 3A 194 4.9 RF01846 URS0000B21E09_559292 32943522 0006396 0005730 559292 gucgacguacuucauaggaucauuucuauaggaaucgucacucuuugacucuucaaaagagccacugaauccaacuugguugaugagucccauaaccuuuguaccccagagugagaaauugccguugcauuuuauggcgcgaugaucuugacccauccuauagggggguggguacaaauggcagucugacaagu .........................................................................<<<<<.................<<<<<<<..<<....<.........<<<............>>>........>...<<<..<<<<..>>>>.>>>.>>.>>>>>.>>........>>>>> .........................................................................(((((......(..........((((((....(....(...(.....(((.....().....))).)......).........(((..)))......)...)))).))....)...))))) Cryo-EM structure of 90S small subunit preribosomes in transition states (State E); U3 snoRNA 6lqt 5A 152 4.9 URS000007769E_559292 32943522 559292 ugcgaaagcaguugaagacaaguggcuugucguucguuaauggccucgcagcgaaggauuugguggauuacuagcuaauagcaaucuaggaaacucaaagagugcuaugcggagugcgcgagagcauuuccggcagcagagauuucagcugu <<<....>>>...<<<<<<<<<...>>>>>>.>>>......................................<<<...>>>...........................<<<<<<<<......>>>>.>>>>.<<<<.<<<..>>>.>>>>. (((....)))...((((((((((.))))))).)))......................................(((...)))...........................((((((((.()...)))).)))).((((.((....)).)))). Cryo-EM structure of 90S small subunit preribosomes in transition states (State E); 5' ETS 6lqt SA 1155 4.9 RF01960,RF01959,RF00177 URS00021ED94D_559292 32943522 0003735 0005840 559292 aagauaguuaucugguugauccugccaguagucauaugcuugucucaaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaaucaguuaucguuuauuugauagcaugguauaacugugguaauucuagagcuaauacaugcuaaucucgacccuuuggaagagauguauuuauuagagucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggggcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauugcucguaguugaacuuugggcccgguuggccgguccggauuuccaacggggccuuuccuuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauagguugguucuauuucuaggaccugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacguagggaucgggugguguuuuuuuaaugacccacucggcaccuugggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcgcgcgcuacacugacggagccagcgaguaacuccgucgugcugacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaaggguuuccguaggugaaccugcggaaggaucauuaa ..............................<..<<<<<<...<......<<<.<<<..<<....<<....<<..........>>...>>.>>....<<<..<<..<<....<<<.......<<....<<.<<<.....>>>.>>.....>>......<<<<<..<<....>>..>>>>><...<<<<<<..<<<<..>>>>....<<......>>>>>>>>.....>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>..<<....<<.....<<<<<<<<.......>>>>>>>>.>>......>>.>>>>>>.........<<<....<<<.....>>>..>>>.........>.....<<<<<<<..<<<<....>>>>..>>>>.>>>......<<..<...........>..>>.........<<<<<<.......<<<....>>>..................>>>>>>..>>>>>>.>.<.<<...<<<.<<.....<<<<<.<<<<<..<.<...>.>..>>>>>.>>>>>........<<<<<.<<............<.......>...<<.....>>.............>>.>>..>>>..........<..<...<..>..>..>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>..>.>>>>.>>>...>>>...>>.>..<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>.....................<<.........>>.....<<<<<<<<<<<<..<<.<<<<<<..<<<.<<<<.>>>>.>>>.....<<<<<<<...........>>>>>>>.............>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>............>>>>>..<<<<.<<....<.<<<<.<..<<..<.<<......<<...<<......<<<<....>>>>......>>...>>......>>.>..>>..>.>>>>>....>>.>>>>.......<<<<<<<<<....>>>>>>>>>.......... ..............................((.((((((...(.(....(((.(((..((....((.....(..........)....))[))....(((..((..((....(((.......((....((.(((.....))).)).....))......(((((..((....))..)))))(.(.((((((..(((....))).....(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..)))..((....((.....((((((((.......)))))))).))......)).)))))).......(.(((...((((.]...))).)))))......).).....((.((((...(((....)))...))))..))....(.(.(.(...........))..)......)..(((((((......(((....)))...............)..))))))..)))))))).(.((...(((.(......(.(((.(((((..(..(..).)..))))).))).)...(....((((..((............(.......)...((.....)).............))..)..)))........).(..(.........)..)......)...((...((.((...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)).))....)..))).)..)).)..(((..((((((((.(((........)))))))))))..))).....................((.........)).....((((((((((((..((..(((((..(((..(((.)))..))).(...(((((((...........)))))))..........)..))))).....((((((((.......))))))))......))...))))))).(......)...)))))..((((.((....((.((((...((..(.((.......((..(..(.(..((.(....).))..).)..)...).).....)).)..))...))))))....)).)))).......((((((((......)))))))).......... Cryo-EM structure of 90S small subunit preribosomes in transition states (State E); 18S pre-rRNA 6lqu 3A 175 3.7 RF01846 URS0000B21E09_559292 32943522 0006396 0005730 559292 gucgacguacuucauaggaucauuucuauaggaaucgucacucuuugacucuucaaaagagccacugaauccaacuugguugaugagucccauaaccuuuguacccagugagaaauugccguugcuauggcgcgaugaucacccauggguggguacaaauggcagucugacaagu .........................................................................<<<<<.................<<<<<<<<<<..<.........<<<<......>>>>.......>.<<<<..>>>>.>>>>>>>>.>>........>>>>> .........................................................................(((((......(..........(((((((((((.(...(.....((((......)))).)......)((((..))))))))))))).))....)...))))) Cryo-EM structure of 90S small subunit preribosomes in transition states (State A1); U3 snoRNA 6lqu 5A 523 3.7 URS000007769E_559292 32943522 559292 ugcgaaagcaguugaagacaaguggcuugucguucguuaaaauggccucgucaaacgguggagagagucgcuaggugaucgucagaucugccuagucucuauacagcguguuuaauugacauggguugaugcguauugagagauacaauuugggaagaaauucccagaguguguuucuuuugcguuuaaccugaacagucucaucgugggcaucuugcgauuccauuggugagcagcgaaggauuugguggauuacuagcuaauagcaaucuauuucaaagaauucaaacuugggggaaugccuuguugaauagccggucgcaagacugugauucuucaaguguaaccuccucucaaaucagcgauaucaaacguaccaccgugaaacaccgggguaucuguuugguggaaccugauuagaggaaacucaaagagugcuaugguauggugacggagugcgcuggucaagaguguaaaagcuuuuugaacagagagcauuuccggcagcagagauuucagcugu <<<....>>>...<<<<<<<<<<.>>>>>>>.>>>..............<<<<<<<<.<<...<<<<..<<<<<<<<<<<....>>>>.>>>>>>>>>>>...>>.>>>......>>>>>..<<<<<..........<<<<<<<<<<.<<<<<<<<....>>>>>>>.>>>>>>>>>>>........>>>>>.......<<<<<<<<<<<...........>>>>>.>>>>>>.........................<<<...>>>.........................<<<<<..<<<<<<<..<<<<...<<<<<....>>>>>.>.>>>..>>>>.>>.>>>>>>.....<<<<<<...<<<<<<<<<<<<<.<<<........>>>>>>>.>.>>>>>>>>....>>>>>>.................................<<<<.<<<.<<<.<<<<<<<<......>>>>.>>>>.>>>...>>>..>>>><<<<<.<<<..>>>.>>>>> (((....)))...((((((((((.))))))).)))..............((((((((.(((..((((..(((((((((((....)))).))))))))))).).)).)))......)))))..(((((.....(.(...((((((..(.((((((((....)))))))).)..))))))..).)....))))).....(.((((((((((((.....)....))))).)))))))........................(((...))).........................(((((..(((((((..((((..((((((....))))).)))))..)))).)).)))))).....((((((....((((((((((((.(((........))))))).).))))))).....)))))).................................((((.(((.(((.((((((((......)))).)))).)))...)))..)))).((((.((.().)).)))). Cryo-EM structure of 90S small subunit preribosomes in transition states (State A1); 5' ETS 6lqu SA 1242 3.7 RF01960,RF01959,RF00177 URS00021ED968_559292 32943522 0003735 0005840 559292 aagauaguuaucugguugauccugccaguagucauaugcuugucucagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaaggcucauuaaaucaguuaucguuuauuugauaguuccaugguauaacugugguaauucuagagcuaauacaugcuaaucucgacccuuuggaagagauguauuuauuagaucaaugucuucggacucuuugaugaaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggccaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaggcucguaguugaacuuagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaacuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcucaacacggggaaacucaccagguccagacacaauaaggauugacauucuugauuuugugggugguggugcauugaugcccuuguucugggccacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauauucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaa ............................<<<<.<<<<<<........<<<.<<...<<....<<....<<..........>>...>>.>>.....<<<.......<<<..<<..<<....<<<..........<.....<<.<<.......>>.>>......>.......<<<<............>>>>.....<<<<<...<<<<..............>>>>...>>>>>.........<<<<...<<.....>>..>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>.....<<...............>>..>>>.<<.<<<..........>>>.>>.<.<<....>>.>....>>>>>......<<<....<<<.....>>>..>>>...............<<<<<<<.<<<<<....>>>>>.>>>.>>>>......<<..<...........>..>>.........<<<<<<.......<<<....>>>..................>>>>>>..>>>>>>>>>>.........<..<.<<...<<<.......<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>..>.>>>>.>>>...>>>...>>.>......<<<<<...<...<<<<.........>>>>...>>>>>>...>....................<<.........>>.....<<<<<<<<<<<<..<<.<<<<<<..<<<.<<<<.......................<<.<....<<<<<........<.....>......>>>>>......<<<........>>>...>.>>.......>>>>.>>>.....<<<<<<<............<<<..<<<<....>>>>..>>>............>>>>>>>.......................>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>............>>>>>..<<<..<<....<.<<<..<.<<<..<.<<......<<<<<<<.<<<<.<<<<....>>>>.>>>>.>>>>>>>......>>.>..>>>.>..>>>>....>>..>>>................<<<<<<<<<....>>>>>>>>> ............................((((.((((((...(.(..(((..(...((....((.....(..........)....)).)).....(((.......(((..((...(....(((..........(.....((.(.(.....).).))......).......((((............)))).(.(.((((.....((..(.(....).)....)).....)))).)...).(.((((...(((..).))..)))))...)))...).))..)))..((....((.....((((((((.......)))))))).))......).).....(.................)..))).((.(((..........))).))...(.......).....).)))......(((...((((.....))).)))).......).).....(((((((((((((....))))))))).))))....(.((..(...........)..))......)..(((((((......(((....)))...............)..))))))..))))))))))..............((...(((......(((.(((.((...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)).)))..))..))).)..))........((((....(...((.(.........).))...).))))........................((.........)).....((((((((((((..((..(((((..((((.(((.......................(...(...(((((.....................)))))....(.((..........)))..)..).......)))).))).(...(((((((............(((..((((....))))..)))............))))))).........(...)......)..))))).....((((((((.......))))))))......))...))))))).(......)...)))))..((((.((.....(....(..(((..(.((..(...((.((((.((((.((.(....).)).)))).)))).))...)..)).)..)))..)...).....)).))))................(((((((((....))))))))) Cryo-EM structure of 90S small subunit preribosomes in transition states (State A1); 18S pre-rRNA 6lqv 3A 175 4.8 RF01846 URS0000B21E09_559292 32943522 0006396 0005730 559292 gucgacguacuucauaggaucauuucuauaggaaucgucacucuuugacucuucaaaagagccacugaauccaacuugguugaugagucccauaaccuuuguacccagugagaaauugccguugcuauggcgcgaugaucacccauggguggguacaaauggcagucugacaagu .........................................................................<<<<<.................<<<<<<<<<<..<.........<<<<......>>>>........><<<<..>>>>.>>>>>>>>.>>........>>>>> .........................................................................(((((......(..........(.(.(((((((.(...(.....((((......)))).)......)((((..))))))))))).)..)....)...))))) Cryo-EM structure of 90S small subunit preribosomes in transition states (State C1); U3 snoRNA 6lqv 5A 171 4.8 URS000007769E_559292 32943522 559292 ugcgaaagcaguugaagacaaguggcuugucguucguuaauggccucguccagcgaaggauuugguggauuacuagcuaauagcaaucuaggaaacucaaagagugcuaugguauggugacggagugcgcugugaacagagagcauuuccggcagcagagauuucagcugu <<<....>>>...<<<<<<<<<<.>>>>>>>.>>>........................................<<<...>>>....................................<<<<.<<<.<<......>>...>>>..>>>><<<<<.<<<..>>>.>>>>> (((....)))...((((((((((.))))))).)))........................................(((...)))....................................((((.(((.(((....)))...)))..)))).((((.((.().)).)))). Cryo-EM structure of 90S small subunit preribosomes in transition states (State C1); 5' ETS 6lqv SA 950 4.8 RF01960,RF01959,RF00177 URS00021ED968_559292 32943522 0003735 0005840 559292 aagauaguuaucugguugauccugccaguagucauaugcuugucucagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaaggcucauuaaaucaguuaucguuuauuugauaguuccaugguauaacugugguaauucuagagcuaauacaugcuaaucucgacccuuuggaagagauguauuuauuagaucaaugucuucggacucuuugaugaaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggccaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcagcuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcucaacacggggaaacucaccagguccagacacaauaaggauugacauucuugauuuugugggugguggugcauugaugcccuuguucugggccacgcgcgcuacacugacggagccagcgagucuagugaaacuccgucgugcuggcaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggcgacaaacuuggucauuuagaggaacuaaaagu ............................<<<<.<<<<<<........<<<.<<...<<....<<....<<..........>>...>>.>>.....<<<.......<<<..<<..<<....<<<..........<.....<<.<<.......>>.>>......>.......<<<<............>>>>.....<<<<<...<<<<..............>>>>...>>>>>.........<<<<...<<.....>>..>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>.....<<...............>>..>>>.<<.<<<..........>>>.>>.<.<<....>>.>....>>>>>......<<<....<<<.....>>>..>>>...............<<<<<<<.<<<<<....>>>>>.>>>.>>>>......<<..<...........>..>>.........<<<<<<.......<<<....>>>..................>>>>>>..>>>>>>>>>>.........<....>....................<<.........>>.....<<<<<<<<<<<<..<<.<<<<<<..<<<.<<<<.......................<<.<....<<<<<........<.....>......>>>>>......<<<........>>>...>.>>.......>>>>.>>>.....<<<<<<<..................>>>>>>>................>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>............>>>>>..<<<<.<<.....<<<<<<<.<<<..<....>..>>>.>>>>>>>....>>.>>>>..... ............................((((.((((((...(.(..(((..(...((....((.....(..........)....)).)).....(((.......(((..((...(....(((..........(.....((.(.(.....).).))......).......((((............)))).(.(.((((.....((..(.(....).)....)).....)))).)...).(.((((...(((..).))..)))))...)))...).))..)))..((....((.....((((((((.......)))))))).))......).).....(.................)..))).((.(((..........))).))...(.......).....).)))......(((...((((.....))).)))).......).).....(((((((((((((....))))))))).))))....(.((..(...........)..))......)..(((((((......(((....)))...............)..))))))..))))))))))...................................((.........)).....((((((((((((..((..(((((..((((.(((.......................(...(...(((((.....................)))))....(.((..........)))..)..).......)))).))).(...(((((((..................))))))).............)..))))).....((((((((.......))))))))......))...))))))).(......)...)))))..((((.((.....((((((..(((..(.().)..)))..))))))....)).))))..... Cryo-EM structure of 90S small subunit preribosomes in transition states (State C1); 18S pre-rRNA 6lsf B 10 2.152 URS000080DEB1_32630 32451382 32630 caggucucuc .......... .......... Crystal structure of the enterovirus 71 polymerase elongation complex (C2S6RA/C2S6RB form); RNA (35-MER) 6lsg B 10 2.14 URS000080DEB1_32630 32451382 32630 gucucucucg .......... .......... Crystal structure of the enterovirus 71 polymerase elongation complex (C0S6M form); RNA (35-MER) 6lsh B 10 2.231 URS0001A24B4D_32630 32451382 32630 aggucucucu .......... .......... Crystal structure of the enterovirus 71 polymerase elongation complex (C2S6M form); RNA (35-MER) 6lsr 2 3482 3.13 RF02543,RF02540 URS0000E60B81_9606 32669547 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugagnccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaanggaaaguugaaaagaacuuugaagngagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcggcccggcggaucuuucccgcgcgggggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcunggaaggcccggcggggaagguggcucgggggcccccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcncucuccccccucccggcgcgccggggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccgggggaggccacgcgcgcgucccccgaagagggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccnucuugnaacncggaccaaggagucuaacacgngcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgagggngcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuagnacccnanagauggugancuaugccugggcagggcgaagccagaggaaacucuggugnagguccguagcgguccugacgugcaaaucgnucguccgaccuggguauagnggcgaaagacuaaucgaaccaucuaguagcuggnucccuccgaaguuucccucaggauagcuggcgcucucgcagacccgacgcccgccacgcaguuuuauccgguaaagcgggccgaaacgaucuccuuuaaaungguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacnuuuggnaagcngaacuggcgcuncgggaugaaccgaacgccggguuaangcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcgccgaaucaacuagcccugaaaauggaugncgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagcggcggcccggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcgnugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguagunnnaaauauucaaacganaacuuugaaggccgaaguggngaaggguuccaugugaacagnanuugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucgnguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgggcggcguccggugagcucucgcuggcccuugaaaauccggggnagaggguguaaaucucgcnccgggccguaccnauauccgcagcaggucuncaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagcnggauccguaacuucgggauaaggauuggcucuaagggcugcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugccnagugcucugaaugucanagugnagaaauucaaugaagcgcggguaaacggcgaagguagcnaanugccucnucaucuaauuagugacgcgcaugaauggaugancgagauucccacugucccuaccuacuauccagcgaaaccacngncaagggaacgngcuuggnggaaucagcngngaaagaaganccuguugagcuugacucuagucuggcacggugaagaguuuucacugacccggngaggcgggggggcgagccccgaggggcucucgcuucuggcgccaancgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccaggugggnaguuugacngnggcgguacaccugucaaacgguancgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucungauuuucagnacgaauacagaccgugaaagcggggccunacgauccuucugaccuuuungguuuuaagcaggannugucagaaaaguuaccacagggauaacuggcugauccuungaugucggcucuuccuaucauugunaagcagaauunaccaagcguungauuguucacccacuaauagggaacgugngcuggnnuuagancgucgugagacagnuuaguuuuacccuncugaugnuguguuguugccaugguaauccugcncaguacgagaggaaccgcagguncanacauuugguguaunugcuuggcugaggagccaauggggcgaagcuacnaucugugggauuaugacunaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccggucccccgccgggguccgguncngagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<<...<<<<<<<<<<<...>>>>>>>.>>>>.....>>>>>..<<<<<<<<<<...<<<<<<<<........<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>...>>>>>>>>..>>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<......>>>..................................<<<<<<<<..<<<.<....<<<<<<<<.<<<.....<<<<<<<<<<<..<<<.<<<........<....<<<<.<<<..<<......>>>>>>>>>.>......>>>....>>>>>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<<<<<<<<<<<<.<<<<...<<..<<<.<<.<<<<......<<<<<<<....>>>>>>>.......>>>>.>>>>>........>>>>>>...>>>>>>>>>>....................<<<<<<.<<<<<<..............>>>>>>.<<<<<<.<<<<.<<<<<<<<<<<.<<<<..<<<....<<........>>....>>>..>>>>.>.>>>>>>>.>>>...>>>>..>>>>.>>..<<<<<<<<<.......>>>>>>>.>>....>>>>>>.....>>>.>>>>>....>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<........>>>>>>..<<<<<...<<<..<<<..(((...[[.>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<......................<<<.<<<<<<<<<...<<<.<<<.<.....>.>>>..>>>...>>>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<..............>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<...........]]...)))............................>>>>>>>>>....>>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<...<....>..>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<..<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<..>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<..>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>..<<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>>.......<...........<<<<<.......>>>>>.....>.....>>.>..>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<.>>>>>>>...<<<<<.....<<<<.......<..........>..................<<<<<<<<<<<.....>>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))].....<<<<<<<..<<<..)))))).>>>>>>>>>>.........>>>>..>>>>>>.......<<.....>>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<.]]]..>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.....<<<<<<<.<<..<<<<....<<<........<<<<<.<<<<....>>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>..............>>>>..>>>>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<.<..<<<<<......>>>>>..>>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((...((((((((((.....)))))).)))).....)))....(((((((((....(((.((((........((((((((..({((((......)))))....[[(...).(((....}]])))...).)))))))...))).))))...)))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....(((((((((((..((((.((.......(......(((.(((..((......))))))))..)......)).)...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((..(.((((........(((((....))))).........))))..))))........))))))..)))))))))))....................((((((.((((((..............)))))).((((((.((((.((((((((((..((((..((.(...................)))..))))...))))))).)))...))))..)))).))..((((((((.........)))))).))..[.)))))).....))).)))))...)))))...)))))))).<((((........))))((((((..(.(((((((((((((..(((..(((((........))))..)..)))...((....))...(((((..........)))))..(((((...(((..(((..[......[[)))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))..).))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((.(((((((......................(((.((((((((....(...(((.(.....).)).)...)....))))))...(((((((((.(......))))))))))....))))))))))))..))..((((..(..(.....)..)..))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.....{.(..)...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((..........]]......]]...........................)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...(.....(((....)))..........((.((((....(....)...)))))).......)....))...(((((........)))))]]((((....(((((...(((((((....)))))))..((((....)))...(...((((((...(((((((((((((((((((((((..{{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....(((((((..))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.((((((((((..))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(...(......(((......)))......).)))))..))))).......((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.(.......((((.((((((..(((((.(((((((((.(((((((.)))))))...(((((.....((((.....................................((((((((((.......))))))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(..((..((((....{..))))..)).)(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......(.......).......(((((.((((((..(.(.((((........))))...).).(((.(.....).))).....)))))..)...))).))....(((((((....))).))))..a..)..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}}.)))))..)).))...))))...)))).((((...((((.....}.......))))...))))..)))...).)))))).....(((((((.((..((((.(..(((........(((((.((((....)))).))))).......)))...(((..(((.....((((.(((((((......)))))))))))....)))..)))...........)..))))..)))))))))(((((.(..(.......)..)....((.(((((((.((.....((((.(..(((((......)))))..)))))....))....)))).))).))..))))).. Cryo-EM structure of a pre-60S ribosomal subunit - state B; 28S rRNA 6lsr 5 120 3.13 RF00001 URS000002B0D5_9606 32669547 0003735 0005840 9606 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. Cryo-EM structure of a pre-60S ribosomal subunit - state B; 5S rRNA 6lsr 8 155 3.13 RF00002 URS00004B2C76_9606 32669547 0003735 0005840 9606 cgacucuuagcggggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu ........................................<<<<<<<<<....>>>>.....<.<<<......>>.............>>>..>...>>>....<<....>><<<<<<<<.......>>>>>>>>.................... ........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))((((((((.......)))))))).................... Cryo-EM structure of a pre-60S ribosomal subunit - state B; 5.8S rRNA 6lss 2 3474 3.23 RF02543,RF02540 URS0000E60B81_9606 32669547 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugagnccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaanggaaaguugaaaagaacuuugaagngagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcggcccggcggaucuuucccgcgcgggggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcunggaaggcccggcggggaagguggcucgggggcccccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcncucuccccccucccggcgcgccggggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccgggggaggccacgcgcgcgucccccgaagagggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccnucuugnaacncggaccaaggagucuaacacgngcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgagggngcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuagnacccnanagauggugancuaugccugggcagggcgaagccagaggaaacucuggugnagguccguagcgguccugacgugcaaaucgnucguccgaccuggguauagnggcgaaagacuaaucgaaccaucuaguagcuggnucccuccgaaguuucccucaggauagcuggcgcucucgcagacccgacgcccgccacgcaguuuuauccgguaaaacuuuaaaungguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacnuuuggnaacngaacuggcgcuncgggaugaaccgaacgccggguuaangcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacaccugccgaaucaacuagcccugaaaauggaugncgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagcggcggcccggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcgnugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguagunnnaaauauucaaacganaacuuugaaggccgaaguggngaaggguuccaugugaacagnanuugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucgnguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccggggnagaggguguaaaucucgcnccgggccguaccnauauccgcagcaggucuncaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagcnggauccguaacuucgggauaaggauuggcucuaagggcugggucggucgcggccggcgccuagcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugccnagugcucugaaugucanagugnagaaauucaaugaagcgcggguaaacggcaagaugancgagauucccacugucccuaccuacuauccagcgaaaccacngncaagggaacgngcuuggnggaaucagcngngaaagaaganccuguugagcuugacucuagucuggcacggugaaguuuuuucacugacccggngaggcgggggggcgagccccgaggggcucucgcuucuggcgccaancgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccaggugggnaguuugacngnggcgguacaccugucaaacgguancgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucungauuuucagnacgaauacagaccgugaaagcggggccunacgauccuucugaccuuuungguuuuaagcaggannugucagaaaaguuaccacagggauauuguggcggccangcguucauagcgacgucgcugaugucggcucuuccuaucauugunaagcagaauunaccaagcguungauuguucacccacuaauagggaacgugngcuggnnuuagancgucgugagacagnuuaguuuuacccuncugaugnuguguuguugccaugguaauccugcncaguacgagaggaaccgcagguncanacauuugguguaunugcuuggcugaggagccaauggggcgaagcuacnaucugugggauuaugacunaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccggucccccgccgggguccgguncngagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>>..<<<<<<<<<<...<<..<<<<........<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>...>>>>..>>..>>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<......>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<<<..<<<<<<<.......<<....<<<<.<<<..<........>>>>>>>>>>......>>>>...>>>>>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<.<<<<<<<<<<<<<<<...<<..<<<.<<.<<<<......<<<<<<<<..>>>>>>>>.......>>>>.>>>>>........>>>>>>..>>>>>>>>>>>....................<<<<<<.<<<<<<<............>>>>>>>.<<<<<<.<<<<.<<<<<<<<<<..<<<<<.<<<<<.<.<........>>..>>>>>.>>>>>...>>>>>>>.>>>...>>>>..>>>>.>>..<<<<<<<<<.......>>>>>>>.>>....>>>>>>......>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<......>>>>>>>..<<<<<...<<<..<<<..[.....(((>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<......................<<<.<<<<<<<<<...<<...>>...>>>>>>>...<<<<<<<<<.........>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<.....>>>>...>>>>>>>>>>>>>..{.......))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<..........))).....]............................>>>>>>>>>....>>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<....<<.....>>..>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<..<<...>>..>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<..<<<<<.<<....>>.>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<<<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>.>.>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<...............<<<<<....<....>.....>>>>><<.<<<<<<<<<<<..<............>.......>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>.......<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>>........>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<........<<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<.....>>>>>...<<<<<.....<<<<.........<....>......................<<<<<<<<<<.......>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))].....<<<<<<<..<<<..)))))).>>>>>>>>>>.........>>>>..>>>>>>>....}..<<<<<<...<<.......>>...>>>>>>((...<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.....))..>>>.....>>>>>..>...>>>>......<<<<<<<....>>>.>>>>........>>>.>>>>>.....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<.]]]..>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.....<<<<<<<.<<..<<<<....<<<........<<<<<.<<<<....>>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>..............>>>>..>>>>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<....<<<<<......>>>>>...>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((...((((((((((.....)))))).)))).....)))....((((((((((...((...(((........((((((((..({((((......)))))....[[(...).(((....}]])))...).)))))))...)))...))..))))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....(((((((((((..(((((((.......((.....(((.((....(.(..).)..))))).))......))))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((..(.((((......(.(((((....))))).).......))))..))))........))))))..)))))))))))....................((((((.(((((((............))))))).((((((.(.((.((((((((((..((((..(((......(......)......)))..))))...))))))).)))...)).)..)))).))..(((((((((.......))))))).))..[.)))))).....))).)))))...)))))...)))))))).<((((........))))((((((..(.(((((((((((((..(((..(((((........))))..)..)))...((....))...(((((.(......).)))))..(((((...(((..(((..[......[[)))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))..).))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((.(((((((......................(((.((((((((....((...))....))))))...(((((((((.(......))))))))))....))))))))))))..))...(((..(.((....)).)..))).....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.....{.(((.(....))))...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((..........]]......]]...........................)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...(.....(((....)))..........((.((((.............)))))).......)....))...(((((........)))))]]((((....(((((...((.(.((....)).).))..((((....)))...(...((((((...(((((((((((((((((((((((..{{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....(((((((.......))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((...(.(.......))........)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(...(((..((((((.(..((....(.(((......))).)....)))))))..)))))...)....)).))))))).)..))).)))))))..))))))....)).[...((((.....>].)))).....(((((..((((.......(((((.((((((..(((((.(((((((((.(((((.....)))))...(((((.....((((.....................................((((((((((.......))))))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(..((..((((....{..))))..)).)(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..))))))).......((((((...((.......))...)))))).[....(((.((((((..(.(.((((........))))...).).(((.....]...))).....)))))..)...))).......(((((((....))).))))..a..)..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}}.)))))..)).))...))))...)))).((((...((((.....}.......))))...))))..)))...).)))))).....((((((..((..((((.(..(((........(((((.((((....)))).))))).......)))...(((..(((.....((((.(((((((......)))))))))))....)))..)))...........)..))))..)).))))))(((((.(..(.......)..)....((.(((((((.((.....((((.(..(((((......)))))..)))))....))....)))).))).))..))))).. Cryo-EM structure of a pre-60S ribosomal subunit - state preA; 28S rRNA 6lss 5 120 3.23 RF00001 URS000002B0D5_9606 32669547 0003735 0005840 9606 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. Cryo-EM structure of a pre-60S ribosomal subunit - state preA; 5S rRNA 6lss 8 156 3.23 RF00002 URS00004B2C76_9606 32669547 0003735 0005840 9606 cgacucuuagcggnggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<.<<.....>>>.....(.<<<......>>.............>>>..)...>>>....<<....>><<<<<<<<<.....>>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))((((((((.......)))))))).................... Cryo-EM structure of a pre-60S ribosomal subunit - state preA; 28S rRNA 6ltp B 42 3.4 URS00021ED927_32630 33067443 32630 agaaauccgucuuucauugacggaacacaggguauuauuuaa ......<<<<<.......>>>>>................... ......((((((...)..)))))................... Crystal structure of Cas12i2 binary complex; crRNA (56-mer RNA) 6ltp H 42 3.4 URS00021ED927_32630 33067443 32630 agaaauccgucuuucauugacggaacacaggguauuauuuaa ......<<<<<.......>>>>>................... ......((((((...)..)))))................... Crystal structure of Cas12i2 binary complex; crRNA (56-mer RNA) 6lu8 2 3477 3.13 RF02543,RF02540 URS0000E60B81_9606 32669547 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugagnccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaanggaaaguugaaaagaacuuugaagngagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcggcccggcggaucuuucccgcgcgggggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcunggaaggcccggcggggaagguggcucgggggcccccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcncucuccccccucccggcgcgccggggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccgggggaggccacgcgcgcgucccccgaagagggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccnucuugnaacncggaccaaggagucuaacacgngcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgagggngcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuagnacccnanagauggugancuaugccugggcagggcgaagccagaggaaacucuggugnagguccguagcgguccugacgugcaaaucgnucguccgaccuggguauagnggcgaaagacuaaucgaaccaucuaguagcuggnucccuccgaaguuucccucaggauagcuggcgcucucgcagacccgacgcccgccacgcaguuuuauccgguaaagcuuaaaungguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacnuuuggnaacngaacuggcgcuncgggaugaaccgaacgccggguuaangcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggaucaccugccgaaucaacuagcccugaaaauggaugncgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagcggcggcccggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcgnugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguagunnnaaauauucaaacganaacuuugaaggccgaaguggngaaggguuccaugugaacagnanuugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucgnguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccggggnagaggguguaaaucucgcnccgggccguaccnauauccgcagcaggucuncaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagcnggauccguaacuucgggauaaggauuggcucuaagggcugggucggucgcggccggcgccuagcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugccnagugcucugaaugucanagugnagaaauucaaugaagcgcggguaaacggcaagguagcaugancgagauucccacugucccuaccuacuauccagcgaaaccacngncaagggaacgngcuuggnggaaucagcngngaaagaaganccuguugagcuugacucuagucuggcacggugaaguuuucacugacccggngaggcgggggggcgagccccgaggggcucucgcuucuggcgccaancgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccaggugggnaguuugacngnggcgguacaccugucaaacgguancgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucungauuuucagnacgaauacagaccgugaaagcggggccunacgauccuucugaccuuuungguuuuaagcaggannugucagaaaaguuaccacagggauauuguggcggccangcguucauagcgacgucgcugaugucggcucuuccuaucauugunaagcagaauunaccaagcguungauuguucacccacuaauagggaacgugngcuggnnuuagancgucgugagacagnuuaguuuuacccuncugaugnuguguuguugccaugguaauccugcncaguacgagaggaaccgcagguncanacauuugguguaunugcuuggcugaggagccaauggggcgaagcuacnaucugugggauuaugacunaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccggucccccgccgggguccgguncngagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>>..<<<<<<<<<<...<<.<<<<<........<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>...>>>>>.>>..>>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<......>>>..................................<<<<<<<<..<<<.<....<<<<<<<<.<<<.....<<<<<<<<<<<..<<<<<<<...<...<<....<<<<.<<<..<<.<..>.>>>>>>>>>>>...>..>>>>...>>>>>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<<<<<<<<<<<<<<<<<...<<..<<<.<<.<<<<......<<<<<<<<..>>>>>>>>.......>>>>.>>>>>........>>>>>>..>>>>>>>>>>>....................<<<<<<.<<<<<<<............>>>>>>>.<<<<<<.<<<<.<<<<<<<<<<.<<<<<<.<<<<<.<...........>..>>>>>.>>>>>.>.>>>>>>>.>>>...>>>>..>>>>.>>..<<<<<<<<<.......>>>>>>>.>>....>>>>>>.....>>>.>>>>>....>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<......>>>>>>>..<<<<<...<<<..<<<..((((.((((>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<......................<<<.<<<<<<<<....<<..>>....>>>>>>...<<<<<<<<<.........>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<....>>>>>...>>>>>>>>>>>>>..{.......))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<..........)))).))))............................>>>>>>>>>....>>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<....<<.....>>..>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<...<<...>>...>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<...<<<<.<<....>>.>>>>...<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<...<..........>........>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<...<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>>........>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<........<<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<...>>>>>...<<<<<.....<<<<..<.....<<....>>.....>...............<<<<<<<<<<.......>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>><<<<....>>>>>>)))].....<<<<<<<..<<<..)))))).>>>>>>>>>>.........>>>>..>>>>>>>....}..<<<<<<...<<.......>>...>>>>>>((...<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.....))..>>>.....>>>>>..>...>>>>......<<<<<<<....>>>.>>>>........>>>.>>>>>.....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<.]]]..>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.....<<<<<<<.<<..<<<<....<<<........<<<<<.<<<<....>>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>..............>>>>..>>>>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<.<..<<<<<......>>>>>..>>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((...((((((((((.....)))))).)))).....)))....((((((((((...((..((((...(....((((((((..({((((......)))))....[[(...).(((....}]])))...).))))))))..))))..))..))))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...(((((((..(((.....(((((((((((..(((((((.......((.....(((.((....(......)..))))).))......))))...))))))))))))))......)))..)).)))))...(((((((((((((((((((((((...((..(((.((.((((......(.(((((....))))).).......)))).)))))........))))))..)))))))))))....................((((((.(((((((............))))))).((((((.(.((.((((((((((..(((((.(((......(......)......)))).))))...))))))).)))...)).)..)))).))..((((((((.........)))))).))..[.)))))).....))).)))))...)))))...)))))))).<((((........))))((((((....(((((((((((((..(((..(((((........))))..)..)))...((....))...(((((.(......).)))))..(((((...(((..(((..[......[[)))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((......................(((.((((((((....(....)....))))))...(((((((((.(......))))))))))....))))))))))))..))...(((..((((....)).)).))).....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.....{.(((.(.....))))...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((..........]]......]]...........................)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...(.....(((....)))..........((.(((...............))))).......)....))...(((((........)))))]]((((....(((((...((.(.((....)).).))..((((....)))...(...((((((...(((((((((((((((((((((((..{{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....(((((((.......))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((.(...(.(.......))........).)))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(...(((..(((((([(]..(......(((......)))......).)))))..)))))........)....)).))))))).)..))).)))))))..))))))....)).[...((((.....>].)))).....(((((..((((.......(((((.((((((..(((((.(((((((((.(((((...)))))...(((((.....((((.....................................((((((((((.......))))))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(..((..((((....{..))))..)).)(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..))))))).......((((((...((.......))...)))))).[....(((.((((((..(.(.((((........))))...).).(((..(..].).))).....)))))..)...))).......(((((((....))).))))..a..)..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}}.)))))..)).))...))))...)))).((((...((((.....}.......))))...))))..)))...).)))))).....((((((..((..((((.(..(((........(((((.((((....)))).))))).......)))...(((...((.....((((.(((((((......)))))))))))....))...)))...........)..))))..)).))))))(((((.(..(.......)..)....((.(((((((.((.....((((.(..(((((......)))))..)))))....))....)))).))).))..))))).. Cryo-EM structure of a human pre-60S ribosomal subunit - state A; 28S rRNA 6lu8 5 120 3.13 RF00001 URS000002B0D5_9606 32669547 0003735 0005840 9606 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. Cryo-EM structure of a human pre-60S ribosomal subunit - state A; 5S rRNA 6lu8 8 156 3.13 RF00002 URS00004B2C76_9606 32669547 0003735 0005840 9606 cgacucuuagcggnggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<.<<.....>>>.....(.<<<......>>.............>>>..)...>>>....<<....>><<<<<<<<<.....>>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))(((((((((....).)))))))).................... Cryo-EM structure of a human pre-60S ribosomal subunit - state A; 5.8S rRNA 6m62 1 2972 3.2 RF02540,RF02543 URS000061F377_559292 32719344 0003735 0005840 559292 guuugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaaacuuuaaauauguaagaaguccuuguuugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcuggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuugggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggagugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ..........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<<.<<<..<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>>..>>>>>>......>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<<.....<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<......>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<....<....>....>>>.>>>.>>....>>>>>>.>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<..<......>..><<<<<<<<<....<<<.<<<<<<......<<<......>>.>......>>>>...<<<<...<...>....>>>>.....>>>>>..>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<......<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>....>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<<..<.<<<....>>>...<...<<<<<<...<<<<.<<<<<<<<<<<<<<<<<<..[[[..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>.>.>>>>>>>.>>>>.........>>>>>>...>.>...>>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<.<<<<<<<<<<....>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>.................>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<....>>>>>....(((((..[[[........[[[...{{.[[[...<<<..<.<<<<<<......<<<<......>.>>>.......<<<<<.....<<<....<<<........>>>................<<<<<<....>>>>>>...>>>..>>>>>.....>>>>>>.>...>>>.......<.<.....<<<<<...........>>>>>........<<<<<<<...<<<<<.........>>>>>.....<<......>>....>>>>>>>...<<<..<<<.........>>>..>>>.<<<....>>>...>.>.......(((((...((((.>>>>>>)))).)))))..........]]]...}}..]]]..............<<<<<...<<.......>>...>>>>>..................<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>>...>>>>......<<<<<<<....>>>.>>>>........]]].)))))....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<....<<<<<<<<<<]]].>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<.....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>..............>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<.<..<<<<........>>>>..>>>>>...>>>....>>>>.>>>>>..>>>>>.. ..........................(((((......(......).......)))).).........((....))...((((......((.....)).....))))...((((.........(((.((((((...)))))).))....)........((.(((.(((((.(..((((((((.(((...({((((......)))))[[(...).(((....}]])))....))).))))..))))..).....)))))))).))...)....(.(((((........))))).).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((.(((((((.......(((((((.......((((((..))))))........))))))).....))))).)).)))))))........(((....)))....))))))))....)))))).)))))..((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).(((((.((....(....)....))..))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)<)))...(((..((.((........)))).)))....))))))))).(.((.......))...)..))))))......).))).((((((....(..((....))..)((...........(((.((((((.....(....(......))......))))...((((.(.((..)).).)))).....)))))..........))..((((.((.((.....)).)).))))....(((......)))...(((((((...((([[[...(.(((((.......(...........((.((((((((((.....{.(((((.(.(...((.........))...).).....(...((......)).).)))))...))))))))))))...........]]].).....)))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........((((((........))))))....))....))...(((((........)))))]]((((..(((.(((...((((....)))...(.[.((((((...((((.((((((((((((((((((..{{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....)))...))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.((((((((...(.)..))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).]...............)).))))))).)..))).)))))))..))))))....)).[..(((((..].)))))....(((((..(((.(.............(.(((...(((......(((.......((.(.......).))........((((.....(((.....(...........)............]...((((((....))))))...)))..)))).......))).......)))..........(.....(((.............)))..........((((((...(((((.........)))))......(......).....))))))....(((..(.(..........))..)))(.(......)..).).........((((....((((.]]]]]]))))..))).).........)))...).....................((.(...((.......))...).))...................((((.((((((..(.(((((((......))))))..).).(.(.(.....).).).....))))))...))))......((.((((....)))..))).....)..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}}.)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......(((.((...(.(.....((.(........((((.((..).).)))).....))).......((((((...(((((.(..(((......)))..).))))).))))))..............).)...)).)))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(((..(..)....)))..)))))...)))....)))).)))))).))))).. Cryo-Em structure of eukaryotic pre-60S ribosome subunit from Saccharomyces cerevisiae rpf2 delta 255-344 strain, C4 state.; RDN25-1 rRNA 6m62 2 158 3.2 RF00002 URS00001BF64E_559292 32719344 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Cryo-Em structure of eukaryotic pre-60S ribosome subunit from Saccharomyces cerevisiae rpf2 delta 255-344 strain, C4 state.; RDN58-1 rRNA 6m62 6 65 3.2 URS000013305B_559292 32719344 559292 ccuucucaaacauucuguuugguagugagugauacucuuuggaguuaacuugaaauugccuuaaa ......<<<<<.....>>>>>.....<<<<...<<<<....>>>>..>>>>.............. .......((((.....)))).....(((((...((((....))))..))))..)........... Cryo-Em structure of eukaryotic pre-60S ribosome subunit from Saccharomyces cerevisiae rpf2 delta 255-344 strain, C4 state.; ITS2-1 miscRNA 6m6s C 12 1.6 URS00021ED8E1_32630 34403472 32630 ngcgcgcgcgcc ............ ............ Crystal structure of Caenorhabditis elegans Dicer-related helicase 3 (DRH-3) C-terminal domain with 5'-ppp 12-mer dsRNA; RNA (5'-R(*(GTP)P*GP*CP*GP*CP*GP*CP*GP*CP*GP*CP*C)-3') 6m6s D 12 1.6 URS00021ED8E1_32630 34403472 32630 ngcgcgcgcgcc ............ ............ Crystal structure of Caenorhabditis elegans Dicer-related helicase 3 (DRH-3) C-terminal domain with 5'-ppp 12-mer dsRNA; RNA (5'-R(*(GTP)P*GP*CP*GP*CP*GP*CP*GP*CP*GP*CP*C)-3') 6mdz C 20 3.4 URS000036142B_9606 31353209 9606 uggagugugacaaugguguu .................... .................... Human Argonaute2-miR-122 bound to a target RNA with two central mismatches (bu2); RNA (5'-R(P*UP*GP*GP*AP*GP*UP*GP*UP*GP*AP*CP*AP*AP*UP*GP*GP*UP*GP*UP*U)-3') 6mdz D 14 3.4 URS000036142B_9606 31353209 9606 uggagugugaaugg .............. .............. Human Argonaute2-miR-122 bound to a target RNA with two central mismatches (bu2); RNA (5'-R(P*UP*GP*GP*AP*GP*UP*GP*UP*GP*AP*CP*AP*AP*UP*GP*GP*UP*GP*UP*U)-3') 6mdz E 23 3.4 URS0000EEACEC_32644 31353209 32644 aaacaccauuuccacacuccaaa ....................... ....................... Human Argonaute2-miR-122 bound to a target RNA with two central mismatches (bu2); RNA (5'-R(P*AP*AP*AP*CP*AP*CP*CP*AP*UP*UP*UP*CP*CP*AP*CP*AP*CP*UP*CP*CP*AP*AP*A)-3') 6mdz F 17 3.4 URS0000EEACEC_32644 31353209 32644 accuuccacacuccaaa ................. ................. Human Argonaute2-miR-122 bound to a target RNA with two central mismatches (bu2); RNA (5'-R(P*AP*AP*AP*CP*AP*CP*CP*AP*UP*UP*UP*CP*CP*AP*CP*AP*CP*UP*CP*CP*AP*AP*A)-3') 6mfn E 10 2.5 URS0000EEAD2B_32630 31353209 32630 ucugugauaa .......... .......... Human Argonaute2-miR-27a bound to HSUR1 target RNA; RNA (5'-R(P*UP*CP*UP*GP*UP*GP*AP*UP*AP*A)-3') 6mfr C 20 3.6 URS000036142B_9606 31353209 9606 uggagugugacaaugguguu .................... .................... Human Argonaute2-miR-122 bound to a target RNA with three central mismatches (bu3); RNA (5'-R(P*UP*GP*GP*AP*GP*UP*GP*UP*GP*AP*CP*AP*AP*UP*GP*GP*UP*GP*UP*U)-3') 6mfr D 14 3.6 URS000036142B_9606 31353209 9606 uggagugugaaugg .............. .............. Human Argonaute2-miR-122 bound to a target RNA with three central mismatches (bu3); RNA (5'-R(P*UP*GP*GP*AP*GP*UP*GP*UP*GP*AP*CP*AP*AP*UP*GP*GP*UP*GP*UP*U)-3') 6mfr E 22 3.6 URS0000EEAD18_32644 31353209 32644 aacaccauuucaacacuccaaa ...................... ...................... Human Argonaute2-miR-122 bound to a target RNA with three central mismatches (bu3); RNA (5'-R(P*AP*AP*AP*CP*AP*CP*CP*AP*UP*UP*UP*UP*CP*AP*CP*AP*CP*UP*CP*CP*AP*AP*A)-3') 6mfr F 16 3.6 URS0000EEAD18_32644 31353209 32644 ccuucaacacuccaaa ................ ................ Human Argonaute2-miR-122 bound to a target RNA with three central mismatches (bu3); RNA (5'-R(P*AP*AP*AP*CP*AP*CP*CP*AP*UP*UP*UP*UP*CP*AP*CP*AP*CP*UP*CP*CP*AP*AP*A)-3') 6mkn A 1507 3.46 RF00177,RF01959,RF01960 URS0000E60B6E_300852 31945376 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuaggaacccgggugaaagccuggggugccccggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagcaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucacuuucu ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<<.....>>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<...........................>>....<<<<<......<..<........>....>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<<..>>>...>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.....)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(..((....))..).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..(.............................)....(((((...(......................)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((.((...((((((....))))))....(((..)))...)).))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...(...(((.....)))).....)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Structure of the Thermus thermophilus 30S ribosomal subunit complexed with an inosine (I34) modified anticodon stem loop (ASL) of Escherichia coli transfer RNA Arginine 2 (TRNAARG2) bound to an mRNA with an CGU-codon in the A-site and paromomycin; 16S rRNA 6mkn X 11 3.46 URS000080E266_562 31945376 562 ggcuicgaacc <<.......>> ((.......)) Structure of the Thermus thermophilus 30S ribosomal subunit complexed with an inosine (I34) modified anticodon stem loop (ASL) of Escherichia coli transfer RNA Arginine 2 (TRNAARG2) bound to an mRNA with an CGU-codon in the A-site and paromomycin; tRNA ASL Escherichia coli Arg2 6mpf A 1508 3.33 RF00177,RF01959,RF01960 URS0000E60B88_300852 31945376 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucac ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<<.....>>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>...<<<<....>>>>...>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<..<.<<<<<<<........>>>>>>>>...>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>....... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.....)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((...(...((((((....))))))....((((....))))...)..))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..((....((.....)).).)...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}...... Structure of the Thermus thermophilus 30S ribosomal subunit complexed with a 2-thiocytidine (s2C32) and inosine (I34) modified anticodon stem loop (ASL) of Escherichia coli transfer RNA Arginine 1 (TRNAARG1) bound to an mRNA with an CGC-codon in the A-site and paromomycin; 16S rRNA 6mpf X 11 3.33 URS000080E223_562 31945376 562 ggnuicgaacc <<.......>> ((.......)) Structure of the Thermus thermophilus 30S ribosomal subunit complexed with a 2-thiocytidine (s2C32) and inosine (I34) modified anticodon stem loop (ASL) of Escherichia coli transfer RNA Arginine 1 (TRNAARG1) bound to an mRNA with an CGC-codon in the A-site and paromomycin; tRNA ASL Escherichia coli Arg1 6mpi A 1507 3.33 RF00177,RF01959,RF01960 URS0000E60B6E_300852 31945376 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuaggaacccgggugaaagccuggggugccccggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagcaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucacuuucu ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<<.....>>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<.............................>....<<<<<......<..<........>....>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<<..>>>...>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.....)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.((.((....)).)).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).)))))).....................................(((((...(......................)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((.((...((((((....))))))....((....))...)).))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...(...(((.....)))).....)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.....]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Structure of the Thermus thermophilus 30S ribosomal subunit complexed with a 2-thiocytidine (s2C32) and inosine (I34) modified anticodon stem loop (ASL) of Escherichia coli transfer RNA Arginine 1 (TRNAARG1) bound to an mRNA with an CGU-codon in the A-site and paromomycin; 16S rRNA 6mpi X 11 3.33 URS000080E266_562 31945376 562 ggnuicgaacc <<.......>> ((.......)) Structure of the Thermus thermophilus 30S ribosomal subunit complexed with a 2-thiocytidine (s2C32) and inosine (I34) modified anticodon stem loop (ASL) of Escherichia coli transfer RNA Arginine 1 (TRNAARG1) bound to an mRNA with an CGU-codon in the A-site and paromomycin; tRNA ASL Escherichia coli Arg1 6mtb 2 76 3.6 RF00005 URS0000868530_9986 30355441 0030533 9986 gucuccguaguguagcgguuaucacguucgccuaacacgcgaaagguccucgguucgaaaccgggcggaaacacca <<.<<<<..<<<..........>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>.>>.... ((.((((..(((.....[....))).(((((.......))))).....(.(((..]....))).))))).)).... Rabbit 80S ribosome with P- and Z-site tRNAs (unrotated state); P-site tRNA 6mtb 4 75 3.6 RF00005 URS000086855F_9986 30355441 0030533 0006412 9986 gcccggauagcucagcuguagagcaucagacuuuuaaucugaggguccaggguucaagucccuguucgggcgcca <<<<<<...<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>.>>>>>>.... ((.((((..((((.......)))).(((((.......))))).....(((((.......))))))))).)).... Rabbit 80S ribosome with P- and Z-site tRNAs (unrotated state); Z-site tRNA 6mtb 5 3597 3.6 RF02540,RF02543 URS0000E60BB9_9986 30355441 0003735 0005840 9986 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggaaauguggcguacggaagacccacuccccggcgccggggggcccaaguccuucugaucgaggcccagcccguggacggugugagnccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaanggaaaguugaaaagaacuuugaagngagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcgcgguccggccgugccggcggggcggaucucccgcucccgucggcgggggaccgccccccggccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcunggaaggccccggcggggaagguggcccgggggccccggguguuacagccccgccccggcagcagcagcucgccgaaucccggggccgagggagcgagacccgugccgccgcgcucuccccccugggggggccgggccaccccucccacggcgcgaccgcuggggcggacuguccagugcgccccgggcgggucgcgccgucgggcccggggggccacgcgucccccgcgagcgcacggggucggcggcgaugucggcuacccacccgacccnucuugnaacncggaccaaggagucuaacacgngcgcgagucgggggcuacgaaagccgccguggcgcaaugaaggugaaggccggcggcgcgccgccggccgaggugggaucccgaggccuuccaguccgccgagggngcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuagnacccnanagauggugancuaugccugggcagggcgaagccagaggaaacucuggugnagguccguagcgguccugacgugcgaaucgnucguccgaccuggguauagnggcgaaagacuaaucgaaccaucuaguagcuggnucccuccaaaguuucccucaggauagcuggcgcucuccgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaaungguaagaagcccggcucgcugguguggagccgggcguggaaugcgagugccuagugggccacnuuuggnaagcngaacuggcgcuncgggaugaaccgaacgccggguuaangcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggaugguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggaugncgcuggagcgucgggcccauacccggccgucgcuggcagucggcagagcgagaaagagaguggcgcggacgcuacgccgcgacgaguaggagggccgcugcgnugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguagunnnaaauauucaaacganaacuuugaaggccgaaguggngaaggguuccaugugaacagnanuugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucagccgaucgaaagggagucgnguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccggggnagaggguguaaaucucgcnccgggccguaccnauauccgcagcaggucuncaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagcnggauccguaacuucgggauaaggauuggcucuaagggcuggcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugccnagugcucugaaugucanagugnagaaauucaaugaagcgcggguaaacggcgggaguaacnaugacucucuuaagguagcnaanugccucnucaucuaauuagugacgcgcaugaauggaugancgagauucccacugucccuaccuacuauccagcgaaaccacngncaagggaacgngcuuggnggaaucagcngngaaagaaganccuguugagcuugacucuagucuggcacggugaagagacaugagaaguguagaauaagugggaggccgccggugaaauaccacuacucugaucguuuuuucacugacccggngaggcgggggggcgagccgggcucucgcuucuggcgccaancgcccggccggccgggcgcgacccgcuccggggacagugccaggugggnaguuugacngnggcgguacaccugucaaacgguancgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucungauuuucagnacgaauacagaccgugaaagcggggccunacgauccuucugaccuuuungguuuuaagcaggannugucagaaaaguuaccacagggauaacuggcuuguggcggccangcguucauagcgacgucgcuuuuugauccuungaugucggcucuuccuaucauugunaagcagaauunaccaagcguungauuguucacccacuaauagggaacgugngcuggnnuuagancgucgugagacagnuuaguuuuacccuncugaugnuguguuguugccaugguaauccugcncaguacgagaggaaccgcagguncanacauuugguguaunugcuuggcugaggagccaauggggcgaagcuacnaucugugggauuaugacunaacgccucuaagucagaaucccgcccaggcggaacgauagcgccggagccucgguuggccucggauagccggucccccgccgggguccgguncngagagcccuucgucccgggaaacggggcggccggaaagggggccgcccucucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcugcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<....<<<...<<<<<<<<<<<...>>>>>>>.>>>>.....>>>....<<<<<<<<<....<<<<<<<<..<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>...>>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<......>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<.....<<<<<<<.<<<<<.<<<<<<<.<<<<<<<<<......>>>>>>>>>>>>>>>>>>>>>>>>>...>>>..>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<.<<<<<<<<<<.<<<<...<<..<<<......<<<......<<<<<<<<.>>>>>>>>.......>>>......>>>.........>>>>>>...>>>>>>>>>>.....<<.......>>......<<<<<<.<<<<<<..>>>>>>....<<<..<<<.<<<<<<<<<<<<<<<<<<<<<<<.<<<<..>>>>.>>>>>>.>>>.>>>>>>>>>>>.>>>...>>>>>.>..............>>>>>>......>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<.....>>>>.....>>>...<<....>>...<<<<<<<........>>>>>>>..<<<<<...<<<..<<<...(((.[[.>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<...<<<.<<<<<<<<<...<<<....<<<..<.<<<..<<<<.<.........>.>>>>>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<......<..........<<<.<<<<<<<<<<.......<<<<<.<<.....................>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>....>>>>>..>>>...>>>>>>><<<<<<.<<<....................]].)))............>>>>>>>>>....>>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<<<<<...>>>>>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<...<<<<<<<....>>>>>>>...<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<<<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>.>.>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<.>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<<<<....<.<<.............<<.................>>....>>.>....>>>>>>>>>>...<<<<<.....<<<<..<<.<<<<<>>.>>>>>..............<<<<<<<<<..>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))].....<<<<<<<..<<<..)))))).>>>>>>>>>>.........>>>>..>>>>>>.......<<...<.<<<<<<...<<.......>>...>>>>>>...>..>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<]]].>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.<<<<<<<..<<<<....<<<........<<<<<..<<<<<.>>>>>.>>>>>.......>>>...<<<..<<<<....<<<<<<<<<........>>>>>>.>>>...>>>>..>>>..............>>>>..>.>>>>>>.<<<<<....................<<.<<<<<<<.<<.....<<<<.<..<<<<<.>>>>>..>>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..(((((((((((.....)))))).))))....))))....(((((((((....((((((((.(((((((((..({((((......)))))....[[(...).(((....}]])))...).)))))))..)))))))))...)))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....(((((((((.....(((((((.(((((.(((((((.((((((((.(.()..)))))))))))))))))))))))))...)))..)))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((..((..(((......((((((((.)))))))).......))))..)..))).........))))))..))))))))))).....(......{..)......((((((.((((((..))))))....(((..(((.(((((((((((((((((((((((.((((..)))).)))))).))).))))))))))).)))...))))).)............[.)))))).....))).)))))...)))))...)))))))).<((((........))))((((((....(((((((((((((..(((..(((((.....))))..)..)))...((....))...(((((((.(....).)))))))..(((((...(((..(..]..[[[.[[[..)..)))....))))).(((((((((.((((......))))))))))).))....)))))))))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((...(((.((((((((....(((....(((..(.(((..((((((.(.....).))))))))).)..)))..)).)....))))))...(((((((((.(......))))))))))....))))))))))))..))..((((..((((.....))))..))))....(((......)))...(((((((...((([[[.....(.(((((......(..........(((.((((((((((.......(((((.(((...................))).....(...((......)).).)))))...)))))))))))))..........]]].)....)))))).)))...)))))))((((((.(((........}.........].]].]]]............)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...(.....(((....)))..........((.((((.(.((...))..))))))).......)....))...(((((........)))))]]((((....(((((...(((((((....)))))))..((((....)))...(...((((((...(((((((((((((((((((((((...{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((.)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(...(......(((......)))......).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.(((((((((.(((((((.((......((......[......(................]..)....))......)).)))))))...(((((.....((((..(...(((().)))..)..............(((((.(((()))).)))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(..((.(((((....{..)))).))).)(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......(....(.((((((...((.......))...))))))...)....)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a.))..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}..)))))..)).))...))))...)))).((((...((((.............))))...))))..)))...).)))))).(((((.(..((((....(((.........((((...((((.))))..))))........)))...(((..(((.....(((.(((((........)))))..)))....)))..)))..............))))..)..))))).(((((.(..(.......)..)....((.(((((((.((.....((((.(..(((((.)))))..)))))....))....)))).))).))..))))).. Rabbit 80S ribosome with P- and Z-site tRNAs (unrotated state); 28S rRNA 6mtb 7 120 3.6 RF00001 URS000002B0D5_9986 30355441 0003735 0005840 9986 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. Rabbit 80S ribosome with P- and Z-site tRNAs (unrotated state); 5S rRNA 6mtb 8 151 3.6 RF00002 URS0000D56C3A_9986 30355441 0003735 0005840 9986 cgacucuuagcggnggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcagguugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<<<<....>>>>.....<.<<<......>>........>>>..>...>>>....<<<..>>><<<<<<<<.......>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]]........)))..)...)))....((....))((((((((.......)))))))).................... Rabbit 80S ribosome with P- and Z-site tRNAs (unrotated state); 5.8S rRNA 6mtb 9 1698 3.6 RF01960,RF01959,RF00177 URS0000E60B90_9986 30355441 0003735 0005840 9986 uaccugguugauccugccaguagcaunugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuauggunccuunggucgcucguacuuggauaacugugguanuucuagngcuaauanaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgcccggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcnaauuacccacucccgacccgggganguagugangaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugagucnacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauancguauauuaaaguugcugcaguunaaaagcucguaguungaucuugggagcggccguccccugcucggcgccggcccgaagcguuuacuuugaaaaaanuagaguguucaaagcaggccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagancgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccacnaggaguggagccugcggcuuaauuugacncaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggcnguucuuaguugguggagcgauuugucugguuaauucngauaacgaacgagacucuggcaugcuaacuaguuacgcgaccccggucggcguaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauunagucccugcccuuuguacacaccgnccgucgnuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggugcccuggcggagcgcugagaagacggucgaacuugncuaucuagaggaaguaaaagucgnancaagguuucnguaggugnnccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<....<<....<<<<<.........<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<<<....>>>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<<.>>>>>>>>.>>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<<..>>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....<<<<<<<<<.<<<....>>>..>>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<....<<<.<<<..>>>.>>><<<<<<<.<<..>>>>>>.>>>.<<<<<<.<.......<<...<.......>.<<<<.>>>>...>>......>.>>>..>>>........<.<<.<<<<<<<...............>>>>>>>.>>.>....>>....<<<<<<..<...<<<<..<<<.<<<<<<<<...<<<......>>>......>>>>>>>>.>>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<......<<<<<........<..<<<........>>>..>......>>>>>......<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<..>>>>.>>>>>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>.........>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>............<<<<<..........>>>>>...........>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<<<<<<<<<<<..>>>>>>>>>.>.>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..((....(((.....(([...((.....((.(((.....))).))......))......))..(((...((((((....))))))...))).((..(((((...(......)..)))))......)).(]((((.((((.)))))))))...)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).).....(((((((((.(((....)))..)))))).)))....(.(...(...........)...)......)..((((([[......((((.....((..]])).......)))).)))))..)))))).)))..[......(.([[...(.(.((...(((..(....(((..((()))..))).((((((.((())))))).))..((((((.(.......((..((.......)).(((.)))....))......).)))..)))........(.((.((((((.................)))))).)).)....)....(((..(.(.(...((((..(((.((((((((...((........))......)))))))).))).......((....))...))))..)..))...))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.(((((....))))))))))).)..)))...((..]]))...))...].))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((.(..(((.((((((......((........))..........(((((.(....(((((.....(..((..((........))..))....).)))))....(.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((...(...((((..((((((((((((..)))).))))))))..))))..).....(((((.....)))))........)))....))).))).....).))))......).)))))...)).)))).))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....(((((..........))))).....)..)..).))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..((((.((...(((((((((((((((..))))))))).).)))))...)).))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}........ Rabbit 80S ribosome with P- and Z-site tRNAs (unrotated state); 18S rRNA 6mtc 4 75 3.4 RF00005 URS000086855F_9986 30355441 0030533 0006412 9986 gcccggauagcucagcuguagagcaucagacuuuuaaucugaggguccaggguucaagucccuguucgggcgcca <<<<<<...<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>.>>>>>>.... ((..(....((((.......)))).(((((.......))))).....(((((.......)))))..)..)).... Rabbit 80S ribosome with Z-site tRNA and IFRD2 (unrotated state); Z-site tRNA 6mtc 5 3597 3.4 RF02540,RF02543 URS0000E60BB9_9986 30355441 0003735 0005840 9986 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggaaauguggcguacggaagacccacuccccggcgccggggggcccaaguccuucugaucgaggcccagcccguggacggugugagnccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaanggaaaguugaaaagaacuuugaagngagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcgcgguccggccgugccggcggggcggaucucccgcucccgucggcgggggaccgccccccggccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcunggaaggccccggcggggaagguggcccgggggccccggguguuacagccccgccccggcagcagcagcucgccgaaucccggggccgagggagcgagacccgugccgccgcgcucuccccccugggggggccgggccaccccucccacggcgcgaccgcuggggcggacuguccagugcgccccgggcgggucgcgccgucgggcccggggggccacgcgucccccgcgagcgcacggggucggcggcgaugucggcuacccacccgacccnucuugnaacncggaccaaggagucuaacacgngcgcgagucgggggcuacgaaagccgccguggcgcaaugaaggugaaggccggcggcgcgccgccggccgaggugggaucccgaggccuuccaguccgccgagggngcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuagnacccnanagauggugancuaugccugggcagggcgaagccagaggaaacucuggugnagguccguagcgguccugacgugcgaaucgnucguccgaccuggguauagnggcgaaagacuaaucgaaccaucuaguagcuggnucccuccaaaguuucccucaggauagcuggcgcucuccgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaaungguaagaagcccggcucgcugguguggagccgggcguggaaugcgagugccuagugggccacnuuuggnaagcngaacuggcgcuncgggaugaaccgaacgccggguuaangcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggaugguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggaugncgcuggagcgucgggcccauacccggccgucgcuggcagucggcagagcgagaaagagaguggcgcggacgcuacgccgcgacgaguaggagggccgcugcgnugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguagunnnaaauauucaaacganaacuuugaaggccgaaguggngaaggguuccaugugaacagnanuugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucagccgaucgaaagggagucgnguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccggggnagaggguguaaaucucgcnccgggccguaccnauauccgcagcaggucuncaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagcnggauccguaacuucgggauaaggauuggcucuaagggcuggcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugccnagugcucugaaugucanagugnagaaauucaaugaagcgcggguaaacggcgggaguaacnaugacucucuuaagguagcnaanugccucnucaucuaauuagugacgcgcaugaauggaugancgagauucccacugucccuaccuacuauccagcgaaaccacngncaagggaacgngcuuggnggaaucagcngngaaagaaganccuguugagcuugacucuagucuggcacggugaagagacaugagaaguguagaauaagugggaggccgccggugaaauaccacuacucugaucguuuuuucacugacccggngaggcgggggggcgagccgggcucucgcuucuggcgccaancgcccggccggccgggcgcgacccgcuccggggacagugccaggugggnaguuugacngnggcgguacaccugucaaacgguancgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucungauuuucagnacgaauacagaccgugaaagcggggccunacgauccuucugaccuuuungguuuuaagcaggannugucagaaaaguuaccacagggauaacuggcuuguggcggccangcguucauagcgacgucgcuuuuugauccuungaugucggcucuuccuaucauugunaagcagaauunaccaagcguungauuguucacccacuaauagggaacgugngcuggnnuuagancgucgugagacagnuuaguuuuacccuncugaugnuguguuguugccaugguaauccugcncaguacgagaggaaccgcagguncanacauuugguguaunugcuuggcugaggagccaauggggcgaagcuacnaucugugggauuaugacunaacgccucuaagucagaaucccgcccaggcggaacgauagcgccggagccucgguuggccucggauagccggucccccgccgggguccgguncngagagcccuucgucccgggaaacggggcggccggaaagggggccgcccucucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcugcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<....<<<...<<<<<<<<<<<...>>>>>>>.>>>>.....>>>....<<<<<<<<<....<<<<<<<<..<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>...>>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<......>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<.....<<<<<<<.<<<<<.<<<<<<<.<<<<<<<<<......>>>>>>>>>>>>>>>>>>>>>>>>>...>>>..>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<.<<<<<<<<<<.<<<<...<<..<<<..<<..<<<......<<<<<<<<.>>>>>>>>.......>>>..>>..>>>.........>>>>>>...>>>>>>>>>>.....<<.......>>......<<<<<<.<<<<<<..>>>>>>...<.<<...<<.<<<<<<<<<<<<<<<<<<<<<<<.<<<<..>>>>.>>>>>>.>>>.>>>>>>>>>>>.>>>...>>.>>.>..............>>>>>>......>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<.....>>>>.....>>>...<<....>>...<<<<<<<........>>>>>>>..<<<<<...<<<..<<<...(((.[[.>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<...<<<.<<<<<<<<<...<<<....<<<..<.<<<..<<<<.<.........>.>>>>>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<......<..........<<<.<<<<<<<<<<.......<<<<<.<<.....................>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>....>>>>>..>>>...>>>>>>><<<<<<.<<<....................]].)))............>>>>>>>>>....>>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<<<<<...>>>>>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<...<<<<<<<....>>>>>>>...<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<.>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<<<<....<.<...........<..<...................>..>..>.>....>>>>>>>>>>...<<<<<.....<<<<..<<.<<.<..>..>>>>..............<<<<<<<<<..>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))].....<<<<<<<..<<<..)))))).>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<]]].>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.<<<<<<<..<<<<....<<<........<<<<<..<<<<<.>>>>>.>>>>>.......>>>...<<<..<<<<....<<<<<<<<<........>>>>>>.>>>...>>>>..>>>..............>>>>..>.>>>>>>.<<<<<.<.............>....<<.<<<<<<<.<<.....<<<<....<<<<<.>>>>>...>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..(((((((((((.....)))))).))))....))))....(((((((((....((((((((.(((((((((..({((((......)))))....[[(...).(((....}]])))...).)))))))..)))))))))...)))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....(((((((((..(..(((((((.(((((.(((((((.((((((((.(.()..)))))))))))))))))))))))))...)))).)))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((..((..(((......((((((((.)))))))).......))))..)..))).........))))))..))))))))))).....(......{..)......((((((.((((((..))))))....(((..(((.(((((((((((((((((((((((.((((..)))).)))))).))).))))))))))).)))...))))).)............[.)))))).....))).)))))...)))))...)))))))).<((((........))))((((((..(.(((((((((((((..(((..(((((.....))))..)..)))...((....))...(((((((.(....).)))))))..(((((...(((..(..]..[[[.[[[..)..)))....))))).(((((((((.((((......))))))))))).))....)))))))))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))....))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((.(((((((...(((.((((((((....(((....(((..(.(((..(((.((.(.....).)).)))))).)..)))..)).)....))))))...(((((((((.(......))))))))))....))))))))))))..))..((((..((((.....))))..))))....(((......)))...(((((((...((([[[.....(.(((((......(..........(((.((((((((((.......(((((..((....(..........)...))......(...((......)).).)))))...)))))))))))))..........]]].)....)))))).)))...)))))))((((((.(((........}.........].]].]]]............)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...(...(.(((....))).....)....((.((((.((((...))).))))))).......)....))...(((((........)))))]]((((....(((((...(((((((....)))))))..((((....)))...(...((((((...(((((((((((((((((((((((...{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((.)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(...(......(((......)))......).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.(((((((((.((((((((((......((......[......(................]..)....))......))))))))))...(((((.....((((..(...(..()...)..)..............(((((.(((()))).)))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(..((.(((((....{..)))).))).)(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......(......((((((...((.......))...))))))........)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a.))..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}..)))))..)).))...))))...)))).((((...((((.............))))...))))..)))...).)))))).(((((....((((....(((.........((((...((((.))))..))))........)))...(((..(((.....(((.(((((........)))))..)))....)))..)))..............)))).....))))).(((((.(..(.......)..)....((.(((((((.((.....((((.(..(((((.)))))..)))))....))....)))).))).))..))))).. Rabbit 80S ribosome with Z-site tRNA and IFRD2 (unrotated state); 28S rRNA 6mtc 7 120 3.4 RF00001 URS000002B0D5_9986 30355441 0003735 0005840 9986 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. Rabbit 80S ribosome with Z-site tRNA and IFRD2 (unrotated state); 5S rRNA 6mtc 8 151 3.4 RF00002 URS0000D56C3A_9986 30355441 0003735 0005840 9986 cgacucuuagcggnggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcagguugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<<<<....>>>>.....<.<<<......>>........>>>..>...>>>....<<<..>>><<<<<<<<.......>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]]........)))..)...)))....((....))((((((((.......)))))))).................... Rabbit 80S ribosome with Z-site tRNA and IFRD2 (unrotated state); 5.8S rRNA 6mtc 9 1698 3.4 RF01960,RF01959,RF00177 URS0000E60B90_9986 30355441 0003735 0005840 9986 uaccugguugauccugccaguagcaunugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuauggunccuunggucgcucguacuuggauaacugugguanuucuagngcuaauanaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgcccggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcnaauuacccacucccgacccgggganguagugangaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugagucnacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauancguauauuaaaguugcugcaguunaaaagcucguaguungaucuugggagcggccguccccugcucggcgccggcccgaagcguuuacuuugaaaaaanuagaguguucaaagcaggccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagancgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccacnaggaguggagccugcggcuuaauuugacncaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggcnguucuuaguugguggagcgauuugucugguuaauucngauaacgaacgagacucuggcaugcuaacuaguuacgcgaccccggucggcguaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauunagucccugcccuuuguacacaccgnccgucgnuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggugcccuggcggagcgcugagaagacggucgaacuugncuaucuagaggaaguaaaagucgnancaagguuucnguaggugnnccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<....<<....<<<<..........<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<<<....>>>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<<.>>>>>>>>..>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<<..>>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....<<<<<<<<<.<<<....>>>..>>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<....<<<.<<<..>>>.>>><<<<<<<.<<..>>>>>>.>>>.<<<<<<.<.......<<...<.......>.<<<<.>>>>...>>......>.>>>..>>>........<.<<.<<<<<<<...............>>>>>>>.>>.>....>>....<<<<<<..<...<<<<..<<<.<<<<<<<<...<<<......>>>......>>>>>>>>.>>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<......<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<..>>>>.>>>>>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.......>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<<<<<<<<<<<..>>>>>>>>>.>.>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..((....(((.....(([...((.....((.(((.....))).))......))......))..(((...((((((....))))))...))).((..(((((...(......)..)))))......)).(]((((.((((.)))))))))...)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).).....(((((((((.(((....)))..)))))).)))....(.((..(...........)..))......)..((((([[......((((.....((..]])).......)))).)))))..)))))).)))..[......(.([[...(.(.((...(((..(....(((..((()))..))).((((((.((())))))).))..((((((.(.......((..((.......)).(((.)))....))......).)))..)))........(.((.((((((.................)))))).)).)....)....((((.(...(...((((..(((.((((((((...((........))......)))))))).))).......((....))...))))..)...)..)))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.(((((....))))))))))).)..)))...((..]]))...))...].))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((..((........))..))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((...(...((((..((((((((((((..)))).))))))))..))))..).....(((((.....)))))........)))....))).))).....).))))).....).)))))...)).)))).))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..((((.((...(((((((((((((((..))))))))).).)))))...)).))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}........ Rabbit 80S ribosome with Z-site tRNA and IFRD2 (unrotated state); 18S rRNA 6mtd 5 3597 3.3 RF02540,RF02543 URS0000E60BB9_9986 30355441 0003735 0005840 9986 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggaaauguggcguacggaagacccacuccccggcgccggggggcccaaguccuucugaucgaggcccagcccguggacggugugagnccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaanggaaaguugaaaagaacuuugaagngagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcgcgguccggccgugccggcggggcggaucucccgcucccgucggcgggggaccgccccccggccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcunggaaggccccggcggggaagguggcccgggggccccggguguuacagccccgccccggcagcagcagcucgccgaaucccggggccgagggagcgagacccgugccgccgcgcucuccccccugggggggccgggccaccccucccacggcgcgaccgcuggggcggacuguccagugcgccccgggcgggucgcgccgucgggcccggggggccacgcgucccccgcgagcgcacggggucggcggcgaugucggcuacccacccgacccnucuugnaacncggaccaaggagucuaacacgngcgcgagucgggggcuacgaaagccgccguggcgcaaugaaggugaaggccggcggcgcgccgccggccgaggugggaucccgaggccuuccaguccgccgagggngcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuagnacccnanagauggugancuaugccugggcagggcgaagccagaggaaacucuggugnagguccguagcgguccugacgugcgaaucgnucguccgaccuggguauagnggcgaaagacuaaucgaaccaucuaguagcuggnucccuccaaaguuucccucaggauagcuggcgcucuccgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaaungguaagaagcccggcucgcugguguggagccgggcguggaaugcgagugccuagugggccacnuuuggnaagcngaacuggcgcuncgggaugaaccgaacgccggguuaangcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggaugguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggaugncgcuggagcgucgggcccauacccggccgucgcuggcagucggcagagcgagaaagagaguggcgcggacgcuacgccgcgacgaguaggagggccgcugcgnugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguagunnnaaauauucaaacganaacuuugaaggccgaaguggngaaggguuccaugugaacagnanuugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucagccgaucgaaagggagucgnguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccggggnagaggguguaaaucucgcnccgggccguaccnauauccgcagcaggucuncaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagcnggauccguaacuucgggauaaggauuggcucuaagggcuggcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugccnagugcucugaaugucanagugnagaaauucaaugaagcgcggguaaacggcgggaguaacnaugacucucuuaagguagcnaanugccucnucaucuaauuagugacgcgcaugaauggaugancgagauucccacugucccuaccuacuauccagcgaaaccacngncaagggaacgngcuuggnggaaucagcngngaaagaaganccuguugagcuugacucuagucuggcacggugaagagacaugagaaguguagaauaagugggaggccgccggugaaauaccacuacucugaucguuuuuucacugacccggngaggcgggggggcgagccgggcucucgcuucuggcgccaancgcccggccggccgggcgcgacccgcuccggggacagugccaggugggnaguuugacngnggcgguacaccugucaaacgguancgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucungauuuucagnacgaauacagaccgugaaagcggggccunacgauccuucugaccuuuungguuuuaagcaggannugucagaaaaguuaccacagggauaacuggcuuguggcggccangcguucauagcgacgucgcuuuuugauccuungaugucggcucuuccuaucauugunaagcagaauunaccaagcguungauuguucacccacuaauagggaacgugngcuggnnuuagancgucgugagacagnuuaguuuuacccuncugaugnuguguuguugccaugguaauccugcncaguacgagaggaaccgcagguncanacauuugguguaunugcuuggcugaggagccaauggggcgaagcuacnaucugugggauuaugacunaacgccucuaagucagaaucccgcccaggcggaacgauagcgccggagccucgguuggccucggauagccggucccccgccgggguccgguncngagagcccuucgucccgggaaacggggcggccggaaagggggccgcccucucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcugcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<...<<<<...<<<<<<<<<<<...>>>>>>>.>>>>.....>>>>...<<<<<<<<<....<<<<<<<<..<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>...>>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<......>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<.....<<<<<<<.<<<<<.<<<<<<<.<<<<<<<<<......>>>>>>>>>>>>>>>>>>>>>>>>>...>>>..>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<.<<<<<<<<<<.<<<<...<<..<<<..<<..<<<......<<<<<<<<.>>>>>>>>.......>>>..>>..>>>.........>>>>>>...>>>>>>>>>>.....<<.......>>......<<<<<<.<<<<<<..>>>>>>...<.<<..<<<.<<<<<<<<<<<<<<<<<<<<<<<.<<<<..>>>>.>>>>>>.>>>.>>>>>>>>>>>.>>>...>>>>>.>..............>>>>>>......>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<.....>>>>.....>>>...<<....>>...<<<<<<<........>>>>>>>..<<<<<...<<<..<<<...(((.[[.>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<...<<<.<<<<<<<<<...<<<....<<<....<<<..<<<<.<.........>.>>>>>>>....>>>..>.>>...>>>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<....................]].)))............>>>>>>>>>....>>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<<<<<...>>>>>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<..<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<<<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>.>.>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<.>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<<<<....<.<<......<...(..(................>..)..).>>.>....>>>>>>>>>>...<<<<<.....<<<<..<<.<<<<...>>>>>>..............<<<<<<<<<..>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))].....<<<<<<<..<<<..)))))).>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<]]].>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.<<<<<<<..<<<<....<<<........<<<<<..<<<<<.>>>>>.>>>>>.......>>>...<<<..<<<<....<<<<<<<<<........>>>>>>.>>>...>>>>..>>>..............>>>>..>.>>>>>>.<<<<<.<.............>....<<.<<<<<<<.<<.....<<<<.<..<<<<<.>>>>>..>>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..(((((((((((.....)))))).))))....))))....(((((((((....((((((((.(((((((((..({((((......)))))....[[(...).(((....}]])))...).)))))))..)))))))))...)))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((..(...((((((((.(((.....(((((((((..(..(((((((.(((((.(((((((.((((((((.(.()..)))))))))))))))))))))))))...)))).)))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((..((..(((......((((((((.)))))))).......))))..)..))).........))))))..))))))))))).....(......{..)......((((((.((((((..))))))....(((..(((.(((((((((((((((((((((((.((((..)))).)))))).))).))))))))))).)))...))))).)............[.)))))).....))).)))))...).)))...)))))))).<((((........))))((((((..(.(((((((((((((..(((..(((((.....))))..)..)))...((....))...(((((((.(....).)))))))..(((((...(((..(((]..[[[.[[[)))..)))....))))).(((((((((.((((......))))))))))).))....)))))))))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))....))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((.(((((((...(((.((((((((....(((....(((..(.(((..(((.((.(.....).)).)))))).)..)))..)).)....))))))...(((((((((.(......))))))))))....))))))))))))..))..((((..((((.....))))..))))....(((......)))...(((((((...((([[[.....(.(((((......(..........(((.((((((((((.......(((((.(((....(.........)....))).....(...((......)).).)))))...)))))))))))))..........]]].)....)))))).)))...)))))))((((((.(((........}.........].]].]]]............)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...(...(.(((....))).....)....((.((((..(((...)))..)))))).......)....))...(((((........)))))]]((((....(((((...(((((((....)))))))..((((....)))...(...((((((...(((((((((((((((((((((((...{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((.)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(...(......(((......)))......).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.(((((((((.((((((((((.......(......[......(................]..)....).......))))))))))...(((((.....((((..((..(((..).)).))..............(((((((((())))))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(..((.(((((....{..)))).))).)(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......(....(.((((((...((.......))...))))))...)....)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a.))..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}..)))))..)).))...))))...)))).((((...((((.............))))...))))..)))...).)))))).((((((...((((....(((.........((((...((((.))))..))))........)))...(((..(((.....(.(.(((((........)))))..).)....)))..)))..............))))....)))))).(((((.(..(.......)..)....((.(((((((.((.....((((.(..(((((.)))))..)))))....))....)))).))).))..))))).. Rabbit 80S ribosome with eEF2 and SERBP1 (unrotated state with 40S head swivel); 28S rRNA 6mtd 7 120 3.3 RF00001 URS000002B0D5_9986 30355441 0003735 0005840 9986 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. Rabbit 80S ribosome with eEF2 and SERBP1 (unrotated state with 40S head swivel); 5S rRNA 6mtd 8 151 3.3 RF00002 URS0000D56C3A_9986 30355441 0003735 0005840 9986 cgacucuuagcggnggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcagguugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<<<<....>>>>.....<.<<<......>>........>>>..>...>>>....<<<..>>><<<<<<<<.......>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]]........)))..)...)))....((....))((((((((.......)))))))).................... Rabbit 80S ribosome with eEF2 and SERBP1 (unrotated state with 40S head swivel); 5.8S rRNA 6mtd 9 1698 3.3 RF01960,RF01959,RF00177 URS0000E60BB4_9986 30355441 0003735 0005840 9986 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucguacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgcccggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcggccguccccugcucggcgccggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccacnaggaguggagccugcggcuuaauuugacncaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggcnguucuuaguugguggagcgauuugucugguuaauucngauaacgaacgagacucuggcaugcuaacuaguuacgcgaccccggucggcguaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauunagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggugcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<....<<....<<<<..........<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<<<....>>>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<<.>>>>>>>>..>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....<<<<<<<<<.<<<....>>>..>>>>>>.>>>......<<..<...........>..>>.........<<<<.<<.......[.......((..>>))..........]..>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<....<<<.<<<..>>>.>>><<<<<<<.<<..>>>>>>.>>>.<<<<<<.<.......<<...<.......>.<<<<.>>>>...>>......>.>>>..>>>........<.<<.<<<<<<<...............>>>>>>>.>>.>....>>....<<<<<<..<...<<<<..<<<.<<<<<<<<...<<<......>>>......>>>>>>>>.>>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<<....>>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<..>>>>.>>>>>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<<<<<<<<<<<..>>>>>>>>>.>.>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..((....(((.....(([...((.....((.(((.....))).))......))......))..(((...(((((......)))))...))).((..(((((...(......)..)))))......)).(]((((.((((.)))))))))...)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).).....(((((((((.((......))..)))))).)))....(.((..(...........)..))......)..((((([[....(.(..(.....((..]])).......)..)))))))..)))))).)))..[......(.([[...(.(.((...(((..(....(((.(((()))).))).((((((.((())))))).))..((((((.(.......((..((.......)).(((.)))....))......).)))..)))........(.((.(((((((...............))))))).)).)....)....(((..(...(...((((..(((.((((((((...((........))......)))))))).))).......((....))...))))..)...)...))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.(((((....))))))))))).)..)))...((..]]))...))...].))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((..((........))..))....).)))))....(.(((...(.((((((....(((.((.((....))...(.((......)))...)).)))....(((...(...((((..((((((((((((..)))).))))))))..))))..).....(((((.....)))))........)))....))).))).....).))))......).)))))...)).)))).))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..((((.((...(((((((((((((((..))))))))).).)))))...)).))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}........ Rabbit 80S ribosome with eEF2 and SERBP1 (unrotated state with 40S head swivel); 18S rRNA 6mte 5 3597 3.4 RF02540,RF02543 URS0000E60BB9_9986 30355441 0003735 0005840 9986 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggaaauguggcguacggaagacccacuccccggcgccggggggcccaaguccuucugaucgaggcccagcccguggacggugugagnccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaanggaaaguugaaaagaacuuugaagngagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcgcgguccggccgugccggcggggcggaucucccgcucccgucggcgggggaccgccccccggccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcunggaaggccccggcggggaagguggcccgggggccccggguguuacagccccgccccggcagcagcagcucgccgaaucccggggccgagggagcgagacccgugccgccgcgcucuccccccugggggggccgggccaccccucccacggcgcgaccgcuggggcggacuguccagugcgccccgggcgggucgcgccgucgggcccggggggccacgcgucccccgcgagcgcacggggucggcggcgaugucggcuacccacccgacccnucuugnaacncggaccaaggagucuaacacgngcgcgagucgggggcuacgaaagccgccguggcgcaaugaaggugaaggccggcggcgcgccgccggccgaggugggaucccgaggccuuccaguccgccgagggngcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuagnacccnanagauggugancuaugccugggcagggcgaagccagaggaaacucuggugnagguccguagcgguccugacgugcgaaucgnucguccgaccuggguauagnggcgaaagacuaaucgaaccaucuaguagcuggnucccuccaaaguuucccucaggauagcuggcgcucuccgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaaungguaagaagcccggcucgcugguguggagccgggcguggaaugcgagugccuagugggccacnuuuggnaagcngaacuggcgcuncgggaugaaccgaacgccggguuaangcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggaugguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggaugncgcuggagcgucgggcccauacccggccgucgcuggcagucggcagagcgagaaagagaguggcgcggacgcuacgccgcgacgaguaggagggccgcugcgnugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguagunnnaaauauucaaacganaacuuugaaggccgaaguggngaaggguuccaugugaacagnanuugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucagccgaucgaaagggagucgnguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccggggnagaggguguaaaucucgcnccgggccguaccnauauccgcagcaggucuncaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagcnggauccguaacuucgggauaaggauuggcucuaagggcuggcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugccnagugcucugaaugucanagugnagaaauucaaugaagcgcggguaaacggcgggaguaacnaugacucucuuaagguagcnaanugccucnucaucuaauuagugacgcgcaugaauggaugancgagauucccacugucccuaccuacuauccagcgaaaccacngncaagggaacgngcuuggnggaaucagcngngaaagaaganccuguugagcuugacucuagucuggcacggugaagagacaugagaaguguagaauaagugggaggccgccggugaaauaccacuacucugaucguuuuuucacugacccggngaggcgggggggcgagccgggcucucgcuucuggcgccaancgcccggccggccgggcgcgacccgcuccggggacagugccaggugggnaguuugacngnggcgguacaccugucaaacgguancgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucungauuuucagnacgaauacagaccgugaaagcggggccunacgauccuucugaccuuuungguuuuaagcaggannugucagaaaaguuaccacagggauaacuggcuuguggcggccangcguucauagcgacgucgcuuuuugauccuungaugucggcucuuccuaucauugunaagcagaauunaccaagcguungauuguucacccacuaauagggaacgugngcuggnnuuagancgucgugagacagnuuaguuuuacccuncugaugnuguguuguugccaugguaauccugcncaguacgagaggaaccgcagguncanacauuugguguaunugcuuggcugaggagccaauggggcgaagcuacnaucugugggauuaugacunaacgccucuaagucagaaucccgcccaggcggaacgauagcgccggagccucgguuggccucggauagccggucccccgccgggguccgguncngagagcccuucgucccgggaaacggggcggccggaaagggggccgcccucucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcugcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<...<<<<...<<<<<<<<<<<...>>>>>>>.>>>>.....>>>>...<<<<<<<<<....<<<<<<<<..<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>...>>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<......>>>..................................<<<<<<<<..<<<.<....<<<<<<<<.<<<.....<<<<<<<<<.....<<<<<<<.<<<<<.<<<<<<<.<<<<<<<<<......>>>>>>>>>>>>>>>>>>>>>>>>>...>>>..>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<.<<<<<<<<<<.<<<<...<<..<<<......<<<......<<<<<<<<.>>>>>>>>.......>>>......>>>.........>>>>>>...>>>>>>>>>>......<.......>.......<<<<<<.<<<<<<..>>>>>>...<.<<..<<<.<<<<<<<<<<<<<<<<<<<<<<<.<<<<..>>>>.>>>>>>.>>>.>>>>>>>>>>>.>>>...>>>>>.>..............>>>>>>......>>.>>>>>....>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<.....>>>>.....>>>...<<....>>...<<<<<<<..<..>..>>>>>>>..<<<<<...<<<..<<<...(((.[[.>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<...<<<.<<<<<<<<<...<<<....<<<..<.<<<..<<<<.<.........>.>>>>>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<....................]].)))............>>>>>>>>>....>>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<<<<<...>>>>>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<...<<<<<<<....>>>>>>>...<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<<<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>.>.>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<.>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<<<<....<.<...........<..<...................>..>..>.>....>>>>>>>>>>...<<<<<.....<<<<..<<..<<<<>>.>>.>>..............<<<<<<<<<..>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))].....<<<<<<<..<<<..)))))).>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<]]].>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.<<<<<<<..<<<<....<<<........<<<<<..<<<<<.>>>>>.>>>>>.......>>>...<<<..<<<<....<<<<<<<<<........>>>>>>.>>>...>>>>..>>>..............>>>>..>.>>>>>>.<<<<<.<.............>....<<.<<<<<<<.<<.....<<<<.<..<<<<<.>>>>>..>>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..(((((((((((.....)))))).))))....))))....(((((((((....((((((((.(((((((((..({((((......)))))....[[(...).(((....}]])))...).)))))))..)))))))))...)))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....(((((((((..(..(((((((.(((((.(((((((.((((((((...()...))))))))))))))))))))))))...)))).)))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((..(...(((......((((((((.)))))))).......)))...)..))).........))))))..)))))))))))............{.........((((((.((((((()))))))...(.((..(((.(((((((((((((((((((((((.((((..)))).)))))).))).))))))))))).)))...))))).)............[.)))))).....))).)))))...)))))...)))))))).<((((........))))((((((....(((((((((((((..(((..(((((.....))))..)..)))...((....))...((((((..........))))))..(((((...(((..(((]..[[[.[[[)))..)))....))))).(((((((((.((((......))))))))))).))....)))))))))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((...(((.((((((((....(((....(((..(.(((..(((.((.(.....).)).)))))).)..)))..)).)....))))))...(((((((((.(......))))))))))....))))))))))))..))..((((..((((.....))))..))))....(((......)))...(((((((...((([[[.....(.(((((......(..........(((.((((((((((.......(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....)))))).)))...)))))))((((((.(((........}.........].]].]]]............)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...(...(.(((....))).....)....((.((((.(.((...)).).)))))).......)....))...(((((........)))))]]((((....(((((...(((((((....)))))))..((((....)))...(...((((((...(((((((((((((((((((((((...{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((.)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(...(......(((......)))......).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.(((((((((.(((((.((((......((......[......(................]..)....))......)))).)))))...(((((.....((((..(.....(()).....)..............(((((.(((()))).)))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((....((((((.(.((((((.......))))))...).((]..[[[))....))))))..(..((..((((....{..))))..)).)(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......(....(.((((((...((.......))...))))))...)....)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a.))..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}..)))))..)).))...))))...)))).((((...((((.............))))...))))..)))...).)))))).(((((....((((....(((.........((((...((((.))))..))))........)))...(((..(((.....(((((((((........)))))).)))....)))..)))..............)))).....)))).)(((((.(..(.......)..)....((.(((((((.((.....((((.(..(((((.)))))..)))))....))....)))).))).))..))))).. Rabbit 80S ribosome with eEF2 and SERBP1 (rotated state); 28S rRNA 6mte 7 120 3.4 RF00001 URS000002B0D5_9986 30355441 0003735 0005840 9986 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. Rabbit 80S ribosome with eEF2 and SERBP1 (rotated state); 5S rRNA 6mte 8 151 3.4 RF00002 URS0000D56C3A_9986 30355441 0003735 0005840 9986 cgacucuuagcggnggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcagguugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<<<<....>>>>.....<.<<<......>>........>>>..>...>>>....<<<..>>><<<<<<<<.......>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]]........)))..)...)))....((....))((((((((.......)))))))).................... Rabbit 80S ribosome with eEF2 and SERBP1 (rotated state); 5.8S rRNA 6mte 9 1698 3.4 RF01960,RF01959,RF00177 URS0000E60B90_9986 30355441 0003735 0005840 9986 uaccugguugauccugccaguagcaunugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuauggunccuunggucgcucguacuuggauaacugugguanuucuagngcuaauanaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgcccggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcnaauuacccacucccgacccgggganguagugangaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugagucnacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauancguauauuaaaguugcugcaguunaaaagcucguaguungaucuugggagcggccguccccugcucggcgccggcccgaagcguuuacuuugaaaaaanuagaguguucaaagcaggccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagancgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccacnaggaguggagccugcggcuuaauuugacncaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggcnguucuuaguugguggagcgauuugucugguuaauucngauaacgaacgagacucuggcaugcuaacuaguuacgcgaccccggucggcguaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauunagucccugcccuuuguacacaccgnccgucgnuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggugcccuggcggagcgcugagaagacggucgaacuugncuaucuagaggaaguaaaagucgnancaagguuucnguaggugnnccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<....<<....<<<<..........<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<<<....>>>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<<.>>>>>>>>..>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>...<<....>>.....>>>>>>.........<<<....<<<.....>>>..>>>..>...>>.>.....<<<<<<<<<.<<<....>>>..>>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<....<<<.<<<..>>>.>>><<<<<<<.<<..>>>>>>.>>>.<<<<<<.<.......<<...<.......>.<<<<.>>>>...>>......>.>>>..>>>........<.<<.<<<<<<<...............>>>>>>>.>>.>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<<....>>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<......<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<..>>>>.>>>>>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.......>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<.<<<<<<<<<..>>>>>>>>>...>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..((....(((.....(([...((.....((.(((.....))).))......))......)).((((...(.(((......))).)...))))((..(((((...(......)..)))))......)).(]((((.((((.)))))))))...)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).).....(((((((((..((....))...)))))).)))....(.((..(...........)..))......)..((((([[......((((.....((..]])).......)))).)))))..)))))).)))..[......(.([[...(.(.((...(((..(....(((..((()))..))).((((((.((())))))).))..((((((.(.......((..((.......)).(((.)))....))......).)))..)))........(.((.(((((((...............))))))).)).)....)....(((.(((..(...((((..((..((((((((...((........))......))))))))..)).......((....))...))))..)..)))..))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.(((((....))))))))))).)..)))...((..]]))...))...].))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((..(...(((((.....(..((..((........))..))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((...(...((((..((((((((((((..)))).))))))))..))))..).....(((((.....)))))........)))....))).))).....).))))).....).)))))...)).)))).))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....((.(((((.......))))).))......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..((((.((...(((((((((((((((..))))))))).).)))))...)).))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}........ Rabbit 80S ribosome with eEF2 and SERBP1 (rotated state); 18S rRNA 6mur G 27 3.1 URS0000E60B95_342948 30503773 342948 guggaaaggcgggcagaggcgguuugc ........................... ........................... Cryo-EM structure of Csm-crRNA-target RNA ternary complex in type III-A CRISPR-Cas system; RNA (27-MER) 6mur H 19 3.1 URS0000E60BAF_342948 30503773 342948 gcaaaccgccucugcccgc ................... ................... Cryo-EM structure of Csm-crRNA-target RNA ternary complex in type III-A CRISPR-Cas system; RNA (5'-R(P*GP*CP*AP*AP*AP*CP*CP*GP*CP*CP*UP*CP*UP*GP*CP*CP*CP*GP*C)-3') 6mus G 33 3.6 URS0000E60B95_342948 30503773 342948 guggaaaggcgggcagaggcgguuugcguauug ................................. ................................. Cryo-EM structure of larger Csm-crRNA-target RNA ternary complex in type III-A CRISPR-Cas system; RNA (33-MER) 6mus H 25 3.6 URS0000E60BAF_342948 30503773 342948 caauacgcaaaccgccucugcccgc ......................... ......................... Cryo-EM structure of larger Csm-crRNA-target RNA ternary complex in type III-A CRISPR-Cas system; RNA (25-MER) 6mut G 20 3.1 URS0000E60B95_342948 30503773 342948 guggaaaggcgggcagaggc .................... .................... Cryo-EM structure of ternary Csm-crRNA-target RNA with anti-tag sequence complex in type III-A CRISPR-Cas system; RNA (5'-R(*GP*UP*GP*GP*AP*AP*AP*GP*GP*CP*GP*GP*GP*CP*AP*GP*AP*GP*GP*C)-3') 6mut H 19 3.1 URS0000E60BC7_342948 30503773 342948 ccucugcccgccuuuccac ................... ................... Cryo-EM structure of ternary Csm-crRNA-target RNA with anti-tag sequence complex in type III-A CRISPR-Cas system; RNA (5'-R(P*CP*CP*UP*CP*UP*GP*CP*CP*CP*GP*CP*CP*UP*UP*UP*CP*CP*AP*C)-3') 6mwn A 92 2.838 RF00228 URS0000EEAD08_12092 31399592 0043022 12092 ngcaaacaucauuuggccuuaaaugggauucugugagaggggaucccuccauugacagcuggacuguucuuuggggccuuaugugguguuug ..<<<<<<<<<<..<<<<......<<<<<<<<.......>>>>>>>>.<<<..<<<<.......>>.>>..>>>>>>>....>>>>>>>>>> ..((((((((((..((((......((((((((.......)))))))).(((..(((((.....))).))..)))))))....)))))))))) Crystal structure of hepatitis A virus IRES domain V in complex with Fab HAVx; HAV dV RNA (92-MER) 6n1d A16S 1517 3.2 RF00177,RF01959,RF01960 URS0000E60BAE_262724 30936299 0003735 0005840 262724 guuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgaggaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucaccuccuuu ......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<......<<<.<<<..<<<..<<.<<<<<<<<<<.....>>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>...>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<.<<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<....<<<......>>>.......>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>...<<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..>.......<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<......>>>..>>>>>>>>.<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<<...>>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.............. ......((((....[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((.(.....).)))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.(((....(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))....)))....((((((...((...((((.........))))...))))))))......{...((((((..((.(((((((...))))))).))...((..]])).....)))))))))).(((......((((....))))....)))...]]]..(((((.(((((((.((..(((((..((((.(((((......((........))..........(((((((..(...((((((((..(((.(((....))).)))...((((....))))..))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..((...(((.....)))).)...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))...)).))).)))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(.(((((..........))))).)......))...)))))))))).))..(.(..((.(.((((.(((..((((((.((((((...(.((((....(((....))).)))).)..)))))).))))))..))).))))..).))...)..)..(((.(((((....))))).)))}............. X-ray Crystal complex showing Spontaneous Ribosomal Translocation of mRNA and tRNAs into a Chimeric Hybrid State; 16S rRNA 6n1d A23S 2879 3.2 RF02540,RF02541,RF00002 URS0000E60B6D_262724 30936299 0003735 0005840 262724 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgucuaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggccuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaaaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagcuccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagacgacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<....<<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.....>>>>>>.>>....<<<<<.....<<....>>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>.............>....>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>...>.>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..<<<<.......>>>>..>>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[....>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<.......<<<<<<<....>>>>>>>....>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<.<.<<.......>>..>>>>>>>...>>>>.>.........<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.......<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> .((........((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([....((.((((.....)))).)).....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....((((((((..[......))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))).......(.(.((((.((((....)))).)))).).[.(.(........).).((((((....(((((.(((((.(..(((...(((.....)))...)))...((....))..((((.....)))).....).))))).)))))..((.(...((((((.....((((((((((.((((....(((((......)))))....)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((.(((((.(...(((((((((...(((...(((.((((.(.((((((......)))).)))..)))).)))..)).)...)))))))))..)..))))).).)...(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((..(((.........)))..))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(((((((....((......(((((.(((....))))))))...))...))))).)).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.((...{{....))))))(((...((((((((((((((((.((.....)))))))))....)))))))))..)))(....(((....)))......))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.(((((.....))))).))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..((.....(...(((((....)))))...).....)))))))..)))))(.(((.........))).)........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((.((((((((((((.(.........(((((..(((.......((((.((....)).))))....)))............)))))).)))))))))))).)))...(((.(....).)))....))))).)))..)))))..(((.......)))((((((...........))))))([((...((.((((.(.(((((.........)))))...).((][.[[[))....)))).))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((.(((..((((((.((......)).)))..))).(((((.....))))).....))).)..)...))).).....(((((((....))).))))..>.)...)))))))))))[...((((((....((((..(.(((((.....(....)....))))).).(((((...(((....(((((((((((.}}.))))))...)))))....))).)))))...(((....((((.....}.......))))....))).))))..].....))))))...(((.....))).....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))....)). X-ray Crystal complex showing Spontaneous Ribosomal Translocation of mRNA and tRNAs into a Chimeric Hybrid State; 23S rRNA 6n1d A5S 119 3.2 RF00001 URS000080DE2B_262724 30936299 0003735 0005840 262724 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......(..(((((....)))))..).......))).)))))))))) X-ray Crystal complex showing Spontaneous Ribosomal Translocation of mRNA and tRNAs into a Chimeric Hybrid State; 5s rRNA 6n1d AMRN 10 3.2 30936299 32630 ggaggaagua .......... .......... X-ray Crystal complex showing Spontaneous Ribosomal Translocation of mRNA and tRNAs into a Chimeric Hybrid State; mRNA 6n1d APTN 76 3.2 RF00005 URS00003179F7_562 30936299 0030533 0006412 562 gggugaunagcucagcugggagagcaccucccunacnaggaggggnucggcggnucgaucccgucaucacccacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((........)))).(((((.......)))).)....(.(((.......))).)))))))).... X-ray Crystal complex showing Spontaneous Ribosomal Translocation of mRNA and tRNAs into a Chimeric Hybrid State; P-tRNA 6n1d B16S 1517 3.2 RF00177,RF01959,RF01960 URS0000E60BAE_262724 30936299 0003735 0005840 262724 guuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgaggaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucaccuccuuu ......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<<<<<<<<<.....>>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<............>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<..<.<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<..<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<.......<<<<<<<..<<<<<<<....>>>>>>>...<<........>>..>>>>>>>..<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<...<<<.....>>>>.>...>>>>>>>.....<<<<<....>>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>.....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.............. ......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((.(.....).)))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.((((.(...))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(.(......((((....))))....).)...]]].](((((..((((((.((..(((.(..((((((((((......((........))..........(((((((..(...((((((((..(((((((....)))))))...((........))..))))))))).((.((....((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..((...(((.....)))).)...)))))))..(..(((((....))))).....)..)))).....).).)))...))..))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((.(........).)))))....)..)..).))).....(((((((......]...)))))))......))...)))))).))).))..(.(..((.(.((((.(((..((((((.((((((...(.((((......(....)...)))).)..)))))).))))))..))).))))..).))...)..)..(((((((((....)))))))))}............. X-ray Crystal complex showing Spontaneous Ribosomal Translocation of mRNA and tRNAs into a Chimeric Hybrid State; 16S rRNA 6n1d B23S 2879 3.2 RF02540,RF02541,RF00002 URS0000E60B6D_262724 30936299 0003735 0005840 262724 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgucuaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggccuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaaaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagcuccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagacgacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<....<<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<<<<<.....>>>>>>.>>....<<<<<.....<<....>>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>.............>....>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<.<.<<<<<<......>>>>.>>>..>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..<<<<.......>>>>..>>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><<<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>.>>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<.<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>.>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<<.....>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...((((((((.....))))))))....{.(((.(((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))..))))....((((((((..[......))))))))....}.(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..((....(((.....)))....))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((.(((.((((....(((((......)))))....)[)))...(((..((((.......<)))).)))..).)).)))))).(.((.......))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((.(.((.(((......)))..)))..))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(.((((((((.....{.(((((.(((..(((.........)))..))).....(...((......)).).)))))...)))))))).).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.((...{{....))))))(((...((((((((((((((((.((.....)))))))))....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...((((.((.....(((....))).......)).)))).}((((.(((..(((((((..((....((...(((((....)))))...))....)))))))..)))))(.(((.........))).)........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((.((.((((((.(.........(((((..(((......(((((.((....)).)))))...)))............)))))).)))))).)).))))))...(((.(....).)))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...((((((....((((..(((((((.....(....)....))))))).(((((...(((....(((((((((((.}}.))))))...)))))....))).)))))...(((....((((.....}.......))))....))).))))..].....))))))...(((.....))).....(((((((((.......)))))....(((.((((.(((....(((((....)))))...)))..))))..)))...))))....))) X-ray Crystal complex showing Spontaneous Ribosomal Translocation of mRNA and tRNAs into a Chimeric Hybrid State; 23S rRNA 6n1d B5S 119 3.2 RF00001 URS000080DE2B_262724 30936299 0003735 0005840 262724 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).)))))))))) X-ray Crystal complex showing Spontaneous Ribosomal Translocation of mRNA and tRNAs into a Chimeric Hybrid State; 5s rRNA 6n1d BATN 85 3.2 RF00005 URS00002D9DE2_562 30936299 0030533 0006412 562 ggugggguucccgagcggccaaagggagcagacunuanaucugccgucaucgacuucgaaggnucgaauccuucccccaccacca <<<<<<<..<<<...........>>>.<<<<<.......>>>>>.<<<...>>>...<<<<<.......>>>>>>>>>>>>.... (((((((..(((.....[.....))).((((.........)))).(((...)))...(((((..]....)))))))))))).... X-ray Crystal complex showing Spontaneous Ribosomal Translocation of mRNA and tRNAs into a Chimeric Hybrid State; A tRNA 6n1d BMRN 17 3.2 30936299 32630 aaggagguaaaaguaua ................. ................. X-ray Crystal complex showing Spontaneous Ribosomal Translocation of mRNA and tRNAs into a Chimeric Hybrid State; mRNA 6n1d BPTN 76 3.2 RF00005 URS00003179F7_562 30936299 0030533 0006412 562 gggugaunagcucagcugggagagcaccucccunacnaggaggggnucggcggnucgaucccgucaucacccacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).(((((.......))))).....(.(((..]....))).)))))))).... X-ray Crystal complex showing Spontaneous Ribosomal Translocation of mRNA and tRNAs into a Chimeric Hybrid State; P-tRNA 6n4o C 19 2.899 URS000036142B_9606 31268608 9606 uggagugugcaaugguguu ................... ................... Human Argonaute2-miR-122 bound to a seed and supplementary paired target; RNA (5'-R(P*UP*GP*GP*AP*GP*UP*GP*UP*GP*AP*CP*AP*AP*UP*GP*GP*UP*GP*UP*UP*U)-3') 6n4o D 14 2.899 URS0000E60B76_32630 31268608 32630 ccauugacacucca .............. .............. Human Argonaute2-miR-122 bound to a seed and supplementary paired target; RNA (5'-R(*CP*CP*AP*UP*UP*GP*UP*CP*AP*CP*AP*CP*UP*CP*CP*AP*AP*A)-3') 6n7p R 558 3.6 RF00488 URS000012D749_559292 31485080 0030627 0000395 0005685 559292 auacuuaccuuaagauaucagaggagaguccuacugaucaaacaugcgcuuccaauaguagaaggacguuaagcauuuaucauugaacuauaauuguucauugaagucauugaugcaaacuccuuggucacacacacauacggcgcggaaggcguguuugcugacguuuccauucccuuguuucaaucauugguuaaucccuugauuccuuuggggauuuuuggguuaaacugauuuuuggggcccuuuguuucuucugccuggagaaguuugacaccaaauucaaauugguguuaggggagcuggggccuuucaaaagagagcuuuguagaggcauucuuuuugacuacuuuucucuagcgugccauuuuaguuuuugacggcagauucgaaugaacuuaaguuuaugaugaagguauggcuguugagauuauuuggucgggauuguaguuugaagaugugcucuuuugagcagucucaacuuugcucguucccguuaugggaaaaauuuuggaaggucuugguaggaacggguggaucuuauaauuuuugauuuau ...........<<<<.<<<<<<<<<...>>>>.>>>>><<<<<<<<<.<<<<<........<<<<<.<<<..<<<<.<.<<<.<<<<.........>>>>.>>>.......>>>>>.>>>>>>>>.....................>>>>>>>>>>>>>><<<.<<<<.<<..<<<<<.<<<<<<<..<<<<<<<<<.<<<..<<<<<<<..>>>>>>>...>>>>>.>>>>>>>..>>>>>>>((.......<<<<<....))>>>>>...<<<<<<<<.......>>>>>>>>.>>>>><<<<<<<<<<<<<<<<<..<<<<...<<.<<<<...<<<<<..<<<<<<..<<<<.......<<<<...<<<<<<<.<<<<<<...<<<<.<<<<<<....>>>>>>..>>>>......>>>>>>>>>>>>>..>>>>.>>>>..>>>>>>.>>>>>..<<<<<....>>>>>.>>>>.>>...>>>>.<<<<<<...>>>>>>...>>>>>>>>>>>>>>>>>.>>>>>>..>>>.>>>>................ ...........((((((((((((((...)))).)))))(((((((((.(((((........(((((.(((..(((((...((.((((.........)))).))........))))).)))))))).(.(...............))))))))))))))))(((.((((.((..(((((((((((((..((..(((...(((..((((((....))))))...)))...)))..))..)))))))[[.......(((((....]])))))...(((((((.((....)))))))))))))))(((((((((((.(((((..((((...((.(((((..(((((..((((((..((((.(...).((((...((.(((..(((.((...((((.((((((....))))))..))))......)).))).))).))..)))).))))..)))))).)))))..(((((....)))))))))).))...)))).((((((...))))))...))))).))))))))))).))))))..))))))))................ S. cerevisiae spliceosomal E complex (UBC4); U1 snRNA 6n7p r 22 3.6 31485080 559292 ucuagaaagguaugucuaaagu ...................... ...................... S. cerevisiae spliceosomal E complex (UBC4); UBC4 pre-mRNA 6n7r R 558 3.2 RF00488 URS000012D749_4932 31485080 0030627 0000395 0005685 4932 auacuuaccuuaagauaucagaggaaaguccuacugaucaaacaugcgcuuccaauaguagaaggacguuaagcauuuaucauugaacuauaauuguucauugaagucauugaugcaaacuccuuggucacacacacauacggcgcggaaggcguguuugcugacguuuccauucccuuguuucaaucauugguuaaucccuugauuccuuuggggauuuuuggguuaaacugauuuuuggggcccuuuguuucuucugccuggagaaguuugacaccaaauucaaauugguguuaggggagcuggggccuuucaaaagagagcuuuguagaggcauucuuuuugacuacuuuucucuagcgugccauuuuaguuuuugacggcagauucgaaugaacuuaaguuuaugaugaagguauggcuguugagauuauuuggucgggauuguaguuugaagaugugcucuuuugagcagucucaacuuugcucguucccguuaugggaaaaauuuuggaaggucuugguaggaacggguggaucuuauaauuuuugauuuau ...........<<<<.<<<<<<<<.....>>>.>>>>><<<<<<<<<.<<<<<........<<<<<.<<<..<<<<.<.<<<.<<<<<.......>>>>>.>>>.......>>>>>.>>>>>>>>.....................>>>>>>>>>>>>>><<<.<<<<.<<..<<<<<.<<<<<<<..<<<<<<<<<.<<<..<<<<<<<..>>>>>>>...>>>>>.>>>>>>>..>>>>>>>((.......<<<<<....))>>>>>...<<<<<<<<.<....>>>>>>>>>.>>>>><<<<<<<<<<<<<<<<<..<<<<...<<.<<<<...<<<<<..<<<<<<..<<<<.......<<<<...<<<<<<<.<<<<<<...<<<<.<<<<<<....>>>>>>..>>>>......>>>>>>>>>>>>>..>>>>.>>>>..>>>>>>.>>>>>..<<<<<....>>>>>.>>>>.>>...>>>>.<<<<<<...>>>>>>...>>>>>>>>>>>>>>>>>.>>>>>>..>>>.>>>>................ ...........((((((((((((((...)))).)))))((((((((([(((((.[......(((((.(((..(((((..(((.((((.........)))).))).......))))).)))))))).(](..............]))))))))))))))))(((.((((.((..(((((((((((((..(((((((...(((..((((((....))))))...)))...)))))))..)))))))[[.......(((((....]])))))...((((((.(.(....).)))))))))))))((((((.((((.(((((..((((...((.(((((..(((((..((((((..((.(.......((((...(((((((.(((.((...((((.((((((....))))))..))))......)).))))))))))..)))).).))..)))))).)))))..(((((....)))))))))).))...)))).((((((...))))))...))))).)))).)))))).))))))..))))))))................ Saccharomyces cerevisiae spliceosomal E complex (ACT1); U1 snRNA 6n7r r 63 3.2 31485080 559292 ugguauguucnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn ..........<<<<<<<<<<<<<<<<<<<.<<<<<<.>>>>>>>>>>>>>>>>>>>>>>>>>. ..........(((((((((((((((((((.((((((.))))))))))))))))))))))))). Saccharomyces cerevisiae spliceosomal E complex (ACT1); ACT1 pre-mRNA 6n8f A 12 NA URS0000E60B9E_32644 30702283 32644 cgcagcuuacgc ............ ............ RNA Duplex containing the internal loop 5'-GCUU/3'-UUCG; RNA (5'-R(*CP*GP*CP*AP*GP*CP*UP*UP*AP*CP*GP*C)-3') 6n8f B 12 NA URS0000E60B8E_32644 30702283 32644 gcgugcuuugcg ............ ............ RNA Duplex containing the internal loop 5'-GCUU/3'-UUCG; RNA (5'-R(*GP*CP*GP*UP*GP*CP*UP*UP*UP*GP*CP*G)-3') 6n8h A 10 NA URS0000E60BD1_32644 30702283 32644 cgggcauccg .......... .......... RNA Duplex containing the internal loop 5'-GCAU/3'-UACG; RNA (5'-R(*CP*GP*GP*GP*CP*AP*UP*CP*CP*G)-3') 6n8h B 10 NA URS0000E60BD1_32644 30702283 32644 cgggcauccg .......... .......... RNA Duplex containing the internal loop 5'-GCAU/3'-UACG; RNA (5'-R(*CP*GP*GP*GP*CP*AP*UP*CP*CP*G)-3') 6n8i A 12 NA URS0000E60B7F_32644 30702283 32644 cgcauucgacgc ............ ............ RNA Duplex containing the internal loop 5'-UUCG/3'-GCUU; RNA (5'-R(*CP*GP*CP*AP*UP*UP*CP*GP*AP*CP*GP*C)-3') 6n8i B 12 NA URS0000E60B62_32644 30702283 32644 gcguuucgugcg ............ ............ RNA Duplex containing the internal loop 5'-UUCG/3'-GCUU; RNA (5'-R(*GP*CP*GP*UP*UP*UP*CP*GP*UP*GP*CP*G)-3') 6n8j 1 3047 3.5 RF02540,RF02543 URS000061F377_559292 30814529 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaucuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauagaggguaccuuuauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[...........<<.<<<<<<...>>>>>>.>>.............<<<<<<.<<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<......<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<<..>>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<...<<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<......>...>>>.>>>.>>....>>>>>>.>>>>>>>.<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<......>>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<......<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>....>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><<<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>.>>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<<<<<<<<<<<<..{{{..>>>>>>....<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>.....<<<<<<<<....>>>>>>>>>>>>.>.>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<.<<<<<<<<<<<....>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<...<<..<<<<<<.<..<<<....<<<<<....>>>>.>...>>>>>>>>..>>>>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{........[[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<<.<<<.<.....>.>>>..>>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>......<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]]]..............<<<<<...<<.......>>...>>>>>...................<<<.<.<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>...>...>>>.......<<<<<<<....>>>.>>>>........}}}.]]]]]....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<.....<<...........<<<<<.....>>>>>.......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>..............>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<.<.........>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((.(.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))...))..................................((....))............(..((((....))))............).....................(((((.(((((......(((((((((((((((((((((((.......(((((((......((((.(....).)))).......))))))).....))))).))))))))))........(((....)))....)))))))).....))))).))))).[((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((((((((((....((.(((((((......................)))))...((((..(((.(......))))..)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((.(.(...((.........))....)).........((......))...)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))((((((((((.((......((((.((((....))))))))...)))))))))).)).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....))).........(((..(.....)...))).....))....))...(((((........)))))]]((((..(((((((...((((....))).....<.((((((...((((.((((((((((((((((((..{{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))....)....))))..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((((.(...)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((..((..((((((.(...((.....((((....)))).....)).)))))..))))....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((........(((((.((((((..(((((.((((((((..(..(.(((((.(.(.........).)..))))).)..)....((((.....((((..((((........))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(..)((((((...........))))))([((....((((((.(.(((.((.......)).)))...).((][.[[[))....))))))....(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))))...............((((...((.......))...))))...................((((.((((((..(.(.(((((......)))))...).).(((..(....).))).....)))))..)...)))..)....(..((((....))).)..)..>.....))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}}.)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......((((((.(((.((....((.(........((((((.....)))))).....))).......((.(((...(((((.(..(((......)))..).))))).))).)).............)).))).))))))..(((((.(..(.......)..)...(.(((((.(((.(((....((((.(..((...(.....)..))..)))))...)))....)))..)))))).))))).. Cryo-EM structure of late nuclear (LN) pre-60S ribosomal subunit; Saccharomyces cerevisiae S288C 35S pre-ribosomal RNA (RDN37-1), miscRNA 6n8j 2 121 3.5 RF00001 URS000055688D_559292 30814529 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<......<...>...>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (.(((((((....((((((((......(((((...(....)...))).)..).....)))))).))((((((.......(((((..((....)).))))).....))))))))))))).). Cryo-EM structure of late nuclear (LN) pre-60S ribosomal subunit; 5S rRNA 6n8j 3 158 3.5 RF00002 URS00001BF64E_559292 30814529 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....)))....((.((((.....]]............).)))..).).)))....((.....))(((((((((....)))))))))..................... Cryo-EM structure of late nuclear (LN) pre-60S ribosomal subunit; 5.8S rRNA 6n8k 1 3201 3.6 RF02540,RF02543 URS000061F377_559292 30814529 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauagaggguguagaauaagugggagcuucggcgccagugaaauaccacuaccuuuauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu .........................<<<<<.....<<....>>......>>>>>...........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[...........<<.<<<<<<...>>>>>>.>>.............<<<<<<.<<<<<..<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>......>>>>>>>>>>>........<<<<<<<........>>>>>>>......((((..<<<<<<))))...]]]..................................<<....>>...............<<<......>>>..................................<<<<<.<<<<<......<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<.<....>.>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<...................<<<<.......>>>>................>>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><..<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>...>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<<<...>>.>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<<<<<<<<<<<<..{{{..>>>>>>....<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>.....<<<<<<<......>>>>>>>>>>>.>.>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<.<<<<<<<<<<<....>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<....<<<<<....>>>>.>...>>>.>>>>..>>>>><<<<<......>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{.....[[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<<<<<<.<............<<<<...<<..>>.............>>>>...>.>>>>.>>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]]]..............<<<<<...<<.......>>...>>>>>...................<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.......<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<.<..<<<<........>>>>..>>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((..((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..)))).)).....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))..(......)..).....................(((((.(((((......(((((((((((((.(((((((((.......(..((((......((((........)))).......))))..).....))))).)))).)))))........(((....)))....)))))))).....))))).))))).<((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...).)))....((..((.((.......A)))).)).....))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((((((((((...(((.(((((((.......(......................((.....))..................)........)))))...((((..(((.(......))))..)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....))).........(..((........))...)....))....))...(((((........)))))]]((((..(((((((...((((....))).....[.((((((...((((.((((((((((((((((((..{{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))....)....))))..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((.......(.......(((((....(.[..).....)))))((.(((((((((((....)))))..)))))).))(...).......(((((((((...((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))((((........))))........((..........(((((.......)))))..)..)....)))....)).))))))).)...)).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.(......(((((.((((((..(((((..(((((((..((((((..((((((..........[...((......(...)...........]...)).....)))).))..))))))....((((.....((((..(((..........)))...........]...(((((..(..))))))..))))..))))......)))))))...)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((.(((((....{..)))).)))).(((....))).))]]].].....(....(..((((.]]]]]])))))....)....)}....))))..)))))))..............(((((.................)))))...................(((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).......(((((((....))).))))..a..)..))).)))))....((((((((..((((.(.(((((.................))))).)(((((...((((....((((((((((}}}.)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......((((...(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).)))...))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(((((......)))))..)))))...)))....)))).)))))).))))).. Cryo-EM structure of early cytoplasmic-immediate (ECI) pre-60S ribosomal subunit; Saccharomyces cerevisiae S288C 35S pre-ribosomal RNA (RDN37-1), miscRNA 6n8k 2 121 3.6 RF00001 URS000055688D_559292 30814529 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Cryo-EM structure of early cytoplasmic-immediate (ECI) pre-60S ribosomal subunit; 5S rRNA 6n8k 3 157 3.6 RF00002 URS00001BF64E_559292 30814529 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>.................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....))))))))).................... Cryo-EM structure of early cytoplasmic-immediate (ECI) pre-60S ribosomal subunit; 5.8S rRNA 6n8l 1 3201 3.6 RF02540,RF02543 URS000061F377_559292 30814529 0003735 0005840 559292 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........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((.(((((.(((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..).))).))....)))))))))))...)....(((((((........))))))).....((.((..[[[[[[)).))..)))..................................((....))............(..((((....))))............).....................(((((.(((((......(((((((((((((((((((((((.......(..((((......((((........)))).......))))..).....))))).))))))))))........(((....)))....)))))))).....))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((........)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((...................(..((.....))..)...............)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(.(((..((...((.........))...))..........((......))...))).)...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....((......)).........(..((........))...)....))....))...(((((........)))))]]((((.(((((((....((((....)))...(.<.((((((...((((.((((((((((((((((((..{{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...)).....)))..)))))))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((....)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))((((........))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((..(((((((..((((((.(((((((..............(..(..(.(...)).............).).....)))).))).))))))....((((.....((((..(((..........)))...........>...((((((....))))))..))))..))))......)))))))...)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....(.(.....((((.]]]]]]))))....))....)}....))))..)))))).......((.(...((((((.................))))))....).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))....))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}}.)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......(.((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).)))).)..(.(((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))).).. Cryo-EM structure of early cytoplasmic-late (ECL) pre-60S ribosomal subunit; Saccharomyces cerevisiae S288C 35S pre-ribosomal RNA (RDN37-1), miscRNA 6n8l 2 121 3.6 RF00001 URS000055688D_559292 30814529 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Cryo-EM structure of early cytoplasmic-late (ECL) pre-60S ribosomal subunit; 5S rRNA 6n8l 3 157 3.6 RF00002 URS00001BF64E_559292 30814529 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>.................... .........................................((((((.[[.....)))....((..(((.....]]............).))...).).)))....((.....))(((((.(((....))).))))).................... Cryo-EM structure of early cytoplasmic-late (ECL) pre-60S ribosomal subunit; 5.8S rRNA 6n8m A 3203 3.5 RF02540,RF02543 URS000061F377_559292 30814529 0003735 0005840 559292 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........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((.(((((.(((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..).))).))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((....(((((((((((((((((((((((.......(..((((......(((..........))).......))))..).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((....((.(((((((......((....(.................((.....))...............)..)).......)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(.(((.(((....(..........)...))).........((......))...)).))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...((((((...((.....)).))))))....[[(((.((...((....(((....)))............((........))........))....))...(((((........)))))]]((((.((((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....))))..)))))))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((....)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((.............)))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..((((.(..((..((..............(((...((....)).............))).....))...))...)))))....((((.....((((..((((........))))...........>...(((((......)))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((.(((((....{..)))).)))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..)))))..(((...((((.....}.......))))...)))..))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..).....(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))..))))).. Cryo-EM structure of pre-Lsg1 (PL) pre-60S ribosomal subunit; Saccharomyces cerevisiae S288C 35S pre-ribosomal RNA (RDN37-1), miscRNA 6n8m B 121 3.5 RF00001 URS000055688D_559292 30814529 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Cryo-EM structure of pre-Lsg1 (PL) pre-60S ribosomal subunit; 5S rRNA 6n8m C 158 3.5 RF00002 URS00001BF64E_559292 30814529 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....)))....((.((((.....]]............).)))..).).)))....((.....))(((((((((....)))))))))..................... Cryo-EM structure of pre-Lsg1 (PL) pre-60S ribosomal subunit; 5.8S RNA 6n8n A 3203 3.8 RF02540,RF02543 URS000061F377_559292 30814529 0003735 0005840 559292 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........................<<<<<<.....<......>......>>>>>.>...{.....<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<.<<<<<<.<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>.>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]....}.............................<<....>>...............<<<......>>>..................................<<<<<.<<<<<.....<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<..<....>..>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<...................<<<<<.....>>>>>...............>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<.....................>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><<.<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>..>>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<<.....>.>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<......>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>.<.<<..<<<..<<<<<<....<<<....<<<<<....>>>>.>...>>>.>>>>..>>>>><<<<...........>>>>........<...........<<<<<.......>>>>>.....>.....>>.>..>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<<<<<<<<............<<<<......................>>>>...>>>>>>.>>>>>>>>>>...<<<<<.....<<<<..<<<<........>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<.<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>...>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<.....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>..............>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<.<..<<<<<......>>>>>..>>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((.(((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..).))).)))...)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.(((((.....(((((((((((((((((((((((.......(..((((......(((..........))).......))))..).....))))).))))))))))........(.(....).)....)))))))).....))))).))))).[((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((..(..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....)..)))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((((((((((...(((.(((((((.....(((.......................(.....)...................)).).....)))))...((((..(((.(......))))..)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(..((.(((....(..........)...))).........((......))...))...)..)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((..(......((((.((((....))))))))...).))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........(((.((........)).)))....))....))...(((((........)))))]]((((.((((((((...((((....))).....<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((.....((((.....(((.....))).....))))......)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))....)....))))..)))))))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((((.(...)))))..)))))).))(...).......(((((((((.].((.........))....((((((....((((.....))))......))))))..}.(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))((((...........))))....................(((((.......)))))..........)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((...((.(((................(...((....)).............).......)))..))...))))).....(((.....((((..((((........))))...........>...((((((....))))))..))))..))).......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((.(((((....{..)))).)))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...(.........)...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(.(((((....))).)).)..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)((((....((((....((((((((((}}..)))))..)))))...))))...)))).(((....((((.....}.......))))....))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(((.((..)..).)))..)))))...)))....)))).)))))).))))).. Cryo-EM structure of Lsg1-engaged (LE) pre-60S ribosomal subunit; Saccharomyces cerevisiae S288C 35S pre-ribosomal RNA (RDN37-1), miscRNA 6n8n B 121 3.8 RF00001 URS000055688D_559292 30814529 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Cryo-EM structure of Lsg1-engaged (LE) pre-60S ribosomal subunit; 5S rRNA 6n8n C 158 3.8 RF00002 URS00001BF64E_559292 30814529 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....)))....((.((((.....]]............).)))..).).)))....((.....))(((((((((....)))))))))..................... Cryo-EM structure of Lsg1-engaged (LE) pre-60S ribosomal subunit; 5.8S rRNA 6n8o A 3201 3.5 RF02540,RF02543 URS000061F377_559292 30814529 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauagaggguguagaauaagugggagcuucggcgccagugaaauaccacuaccuuuauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>...{.....<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<.<<<<<<.<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>.>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]....}.............................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<.....<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<..<....>..>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<.....<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>...<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<<<<<<<<<<<<..{{{..>>>>>>....<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>.....<<<<<<<......>>>>>>>>>>>.>.>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<...............>>>>><<.<<<<<<<<<<<..>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>.<.<<..<<<..<<<<<..<..<<<....<<<<<....>>>>.>...>>>>.>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>.>..>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<<<<<<<<............<<<<......................>>>>...>>>>>>.>>>>>>>>>>...<<<<<.....<<<<..<<<<........>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<.<..<<<<<......>>>>>..>>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((.((.((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..)))).).)....)))))))))))...)....(((((((........)))))))......((((..[[[[[[))))...)))..................................((....))............(..((((....))))............).....................(((((.(((((.....(((((((((((((((((((((((.......(..((((......(((.(......).))).......))))..).....))))).))))))))))........(((....)))....)))))))).....))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...(((.((.....)).))).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{....((.(((...................))).....(...((......)).).))......)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...((((((...((.....)).))))))....[[(((.((...((....(((....))).........(..((........))..).....))....))...(((((........)))))]]((((.((((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....))))..)))))))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((..)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))((((.(.......).))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((...((((((.(............(((...((....)).............)))....))))).))...)))))....((((.....((((..((((........))))...........>...(((((......)))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Cryo-EM structure of Rpl10-inserted (RI) pre-60S ribosomal subunit; Saccharomyces cerevisiae S288C 35S pre-ribosomal RNA (RDN37-1), miscRNA 6n8o B 121 3.5 RF00001 URS000055688D_559292 30814529 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Cryo-EM structure of Rpl10-inserted (RI) pre-60S ribosomal subunit; 5S rRNA 6n8o C 158 3.5 RF00002 URS00001BF64E_559292 30814529 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Cryo-EM structure of Rpl10-inserted (RI) pre-60S ribosomal subunit; 5.8S rRNA 6n9e 1A 2871 3.7 RF02540,RF02541,RF00002 URS00001698E8_274 30520988 0003735 0005840 274 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>....<<<<<.....<......>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<....<<...<<<<<<<<.....<<<........>>>......>>>>>>>>..>>.....>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..<<<.......>>>...>>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...((((((((.....))))))))....{.(((((((((...((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).))))....((((((((..[......))))))))....}.(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((()))....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...((((.(((.(...((..........))...)..))).))))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((..((.........))...))).........((......))...)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(.(((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....)))).)...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((.(((((((((.(......[..(((((..(((......(((((.((....)).)))))...)))..........].)))))).))))))))).))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..(((...))).(..(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))..).))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with a short substrate mimic CC-Pmn and bound to mRNA and P-site tRNA at 3.7A resolution; 23S Ribosomal RNA 6n9e 1B 120 3.7 RF00001 URS000080DEE8_274 30520988 0003735 0005840 274 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<.....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>..>>>>>>>>>. .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the Thermus thermophilus 70S ribosome in complex with a short substrate mimic CC-Pmn and bound to mRNA and P-site tRNA at 3.7A resolution; 5S Ribosomal RNA 6n9e 1a 1500 3.7 RF00177,RF01959,RF01960 URS000080DFED_274 30520988 0003735 0005840 274 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<...<<<<<<......>>>>>.>...>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<.<<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<....<<<......>>>.......>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<.<<<<....>>>>.>>...<.<......>>...>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((.((....)).)))).)))))......(((......((((((((..((...((((.((.(((((......((((....)))).......)))))....((((.(((((....))))).))))...((((...)))).)).))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((..((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((.(((....))).)))....(((....)))....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))).))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the Thermus thermophilus 70S ribosome in complex with a short substrate mimic CC-Pmn and bound to mRNA and P-site tRNA at 3.7A resolution; 16S Ribosomal RNA 6n9e 1x 76 3.7 RF00005 URS000041AF00_562 30520988 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with a short substrate mimic CC-Pmn and bound to mRNA and P-site tRNA at 3.7A resolution; P-site tRNA, Deacylated Initiator Methionyl-tRNA 6n9e 2A 2800 3.7 RF02540,RF02541,RF00002 URS00001698E8_274 30520988 0003735 0005840 274 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>....<<<<<.....<......>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<....<<...<<<<<<<<...<<<<..........>>.>>...>>>>>>>>..>>.....>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<..>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<..>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> ((.......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...((((((((.....))))))))....[.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).))))....((((((((..{......))))))))....].(((((}.[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((()))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...).)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...((((((((....(((..........)).)....))))))))..)).)...)))))))))..).]))))))).))..(.(((((.((......)).)))).))......((......))....((((.(((...((([[[...(.((((((.....(.....((..((((((((....)))))))).))..........]]].)....))))))))))...)))))))(((((((..)))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.[..).....)))))((((((((((((.....))))))))))))(...).......(((((((((...((.........))...(((((((.....(((....))).......))))))).]((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((.(.((((((((((.(......[..(((((...((.......((((.((....)).))))....))...........].)))))).)))))))))).).)))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....((.((((.((..]]]]..)))))).)).....)}......))))..))))))......(((((.(.((((((....(.......)....))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....(((.(............))))....))).))))..]....)))))))((((.))).....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))...).)) Crystal structure of the Thermus thermophilus 70S ribosome in complex with a short substrate mimic CC-Pmn and bound to mRNA and P-site tRNA at 3.7A resolution; 23S Ribosomal RNA 6n9e 2B 120 3.7 RF00001 URS000080DEE8_274 30520988 0003735 0005840 274 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<.....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>..>>>>>>>>>. .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the Thermus thermophilus 70S ribosome in complex with a short substrate mimic CC-Pmn and bound to mRNA and P-site tRNA at 3.7A resolution; 5S Ribosomal RNA 6n9e 2a 1503 3.7 RF00177,RF01959,RF01960 URS000080DFED_274 30520988 0003735 0005840 274 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggau .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<.<<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<....<<<......>>>.......>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<......>>....>>>>>>>.<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>.... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((.(....).)))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(.(((....)))..))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((.((....((........)).......)).)))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((.(((((((...))))))).))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((((((....))))))).(..(........)..).)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}... Crystal structure of the Thermus thermophilus 70S ribosome in complex with a short substrate mimic CC-Pmn and bound to mRNA and P-site tRNA at 3.7A resolution; 16S Ribosomal RNA 6n9e 2x 76 3.7 RF00005 URS000041AF00_562 30520988 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with a short substrate mimic CC-Pmn and bound to mRNA and P-site tRNA at 3.7A resolution; P-site tRNA, Deacylated Initiator Methionyl-tRNA 6n9f 1A 2871 3.7 RF02540,RF02541,RF00002 URS00001698E8_274 30520988 0003735 0005840 274 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>....<<<<<.....<......>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<....<<...<<<<<<<<.....<<<........>>>......>>>>>>>>..>>.....>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..<<.........>>...>>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>>....<<<..>>>......>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<.<<....>>.>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((...((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....((((((((..[......))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...).)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((.(..(((..........)..)))..)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((..((.........))...))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.[..).....)))))((((((((((((.....))))))))))))(...).......(((((((((...((.........))...(((((((.....(((....))).......))))))).]((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((.(((((((((.(......[..(((((..(((......(((((.((....)).)))))...)))..........].)))))).))))))))).))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..(((...)))....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))....))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with a short substrate mimic ACCA-DPhe and bound to mRNA and P-site tRNA at 3.7A resolution; 23S Ribosomal RNA 6n9f 1B 120 3.7 RF00001 URS000080DEE8_274 30520988 0003735 0005840 274 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>>. .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the Thermus thermophilus 70S ribosome in complex with a short substrate mimic ACCA-DPhe and bound to mRNA and P-site tRNA at 3.7A resolution; 5S Ribosomal RNA 6n9f 1a 1500 3.7 RF00177,RF01959,RF01960 URS000080DFED_274 30520988 0003735 0005840 274 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<.<<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>.<.<.<......>>.>..>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((.((....)).)))).)))))......(((......((((((((..((...(((((((.(((((.....(((((....)))))......)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(.(((....)))..))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((..((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((....((.(((....))).)).....(((....)))....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))).))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the Thermus thermophilus 70S ribosome in complex with a short substrate mimic ACCA-DPhe and bound to mRNA and P-site tRNA at 3.7A resolution; 16S Ribosomal RNA 6n9f 1x 76 3.7 RF00005 URS000041AF00_562 30520988 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with a short substrate mimic ACCA-DPhe and bound to mRNA and P-site tRNA at 3.7A resolution; P-site tRNA, Deacylated Initiator Methionyl-tRNA 6n9f 2A 2800 3.7 RF02540,RF02541,RF00002 URS00001698E8_274 30520988 0003735 0005840 274 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>....<<<<<.....<......>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<....<<...<<<<<<<<...<<<<..........>>.>>...>>>>>>>>..>>.....>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<..>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((()))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((....(((..........)).)....)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((....)))))))).))..........]]].)....))))))))))...)))))))(((((((())))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((.(((((((.((.....)))))))))......))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((.(.((((((((((.(......[..(((((...((.......((((..(....)..))))....))...........].)))))).)))))))))).).)))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....((.((((.((..]]]]..)))))).)).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))((((.))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with a short substrate mimic ACCA-DPhe and bound to mRNA and P-site tRNA at 3.7A resolution; 23S Ribosomal RNA 6n9f 2B 120 3.7 RF00001 URS000080DEE8_274 30520988 0003735 0005840 274 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>. .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the Thermus thermophilus 70S ribosome in complex with a short substrate mimic ACCA-DPhe and bound to mRNA and P-site tRNA at 3.7A resolution; 5S Ribosomal RNA 6n9f 2a 1503 3.7 RF00177,RF01959,RF01960 URS000080DFED_274 30520988 0003735 0005840 274 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggau .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<.<<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<......>>....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>.... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(.(((....)))..))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((.(((((...))))).))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].]((((..(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((((((....))))))).(..............).)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...))))))).)).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}... Crystal structure of the Thermus thermophilus 70S ribosome in complex with a short substrate mimic ACCA-DPhe and bound to mRNA and P-site tRNA at 3.7A resolution; 16S Ribosomal RNA 6n9f 2x 76 3.7 RF00005 URS000041AF00_562 30520988 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(.(((..]....))).)))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with a short substrate mimic ACCA-DPhe and bound to mRNA and P-site tRNA at 3.7A resolution; P-site tRNA, Deacylated Initiator Methionyl-tRNA 6nd4 0 408 4.3 URS0000EEACF1_1247190 31206356 1247190 gaagacaagugcuugucguucguuaauggccucgucaaacgguggagagagucgcuaggugaucgucagaucugccuagucucuauacagcguguuuaauugacauggguugaugcguauugagagauauguuucuuuugcguuuaaccugaacagucucaucgugggcaucuuccauuggugagcagcgaaggauuugguggauuacuagcuaauagcaaucuauuucaaagaauucaaacuugggggaaugccuuguugaauauucuucaaguguaaccuccucucaaaucagcugauuagaggaaacucaaagagugcuauggcggagugcgcuggucaagaguguaaaagcuuuuugaacagagagcauuuccgcagcagagauuucagcuguunnnnnnnnnn <<<<<<<<<..>>>>>>.>>>............<<<<<<<<.<<...<<<<..<<<<<<<.<<<....>>>..>>>>>>>>>>>...>>.>>>......>>>>>..<<<<<<..<<<<<..<<<<<<<<>>>>>>>>.>>>>>.>>>>>>.......<<<<<.<<<<.......>>>>..>>>>>.........................<<<...>>>.........................<<<<<...<<<<<<..<<<..>>>..>>>>.>>..>>>>>.....<<<<<..>>>>>..........................<<<.<<<.<<<.<<<<<<<<......>>>>.>>>>.>>>...>>>..>>><<<<<.<<<..>>>.>>>>>........... (..((((((()))))))...)............((((((((.((...((((..(((((((.(((....)))..)))))))))))...)).)))......)))))..(((((...(((((..(..((((()))))..).)))))..))))).....(.((((((((((.......)))).)))))))........................(((...))).........................(((((..(((((((..(((..)))..)))).)).)))))).....((((....))))..........................(((.(((.(((.((((...............)))).)))...)))..)))(((((..(.().)..)))))........... Conformational switches control early maturation of the eukaryotic small ribosomal subunit; 5'ETS rRNA 6nd4 1 15 4.3 31206356 1247190 nnnnnnnnugauccu ............... ............... Conformational switches control early maturation of the eukaryotic small ribosomal subunit; 18S rRNA 5' domain start 6nd4 2 146 4.3 RF01846 URS0000EEAD32_1247190 31206356 0006396 0005730 1247190 aggaucaggaaucgucacucuuugacucuucaaaagagccacugaauccaacuugguugaugagucccauaaccuuuguacccagugagaaaccguauggcgcgaugaucuacccauggguggguacaaauggcagucugacaagu ..................................................<<<<<.................<<<<<<<<<<..<.......<<<..>>>.........>.<<<....>>>.>>>>>>>>.>>........>>>>> ..................................................(((((......(..........((((((((((..(...(...(......)..)......).(((....))).)))))))).))....)...))))) Conformational switches control early maturation of the eukaryotic small ribosomal subunit; U3 snoRNA 6nd5 1A 2871 2.6 RF02540,RF02541,RF00002 URS00001698E8_300852 30733327 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<.....<<<........>>>......>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<....<......(..>.....>>.........<<......>>.).>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<.<<<..>>>.>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((..(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((.(..((((........)))..))..)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((..((.........))...))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((.((((((((.(......[..(((((..(((......(((((.((....)).)))))...)))..........].)))))).)))))))).)))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((...)))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with chloramphenicol and bound to mRNA and A-, P-, and E-site tRNAs at 2.60A resolution; 23S Ribosomal RNA 6nd5 1B 120 2.6 RF00001 URS000080DEE8_300852 30733327 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>>> (((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).))))))))))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with chloramphenicol and bound to mRNA and A-, P-, and E-site tRNAs at 2.60A resolution; 5S Ribosomal RNA 6nd5 1a 1500 2.6 RF00177,RF01959,RF01960 URS000080DFED_300852 30733327 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>.....<......>.....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((((((....))))))).)))))......(((......((((((((..((...(((((((.(((((....(.((((....)))).).....)))))....((((...(((....)))...))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((...(((.(((....))).)))....((......))....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the Thermus thermophilus 70S ribosome in complex with chloramphenicol and bound to mRNA and A-, P-, and E-site tRNAs at 2.60A resolution; 16S Ribosomal RNA 6nd5 1v 13 2.6 30733327 10665 aaaaauguucuaa ............. ............. Crystal structure of the Thermus thermophilus 70S ribosome in complex with chloramphenicol and bound to mRNA and A-, P-, and E-site tRNAs at 2.60A resolution; mRNA 6nd5 1w 74 2.6 RF00005 URS00005AA258_562 30733327 0030533 0006412 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<......>>>><<<<<<<.....>>>>>>.>...<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[..)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with chloramphenicol and bound to mRNA and A-, P-, and E-site tRNAs at 2.60A resolution; A-site and E-site tRNAs 6nd5 1x 76 2.6 RF00005 URS000041AF00_562 30733327 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with chloramphenicol and bound to mRNA and A-, P-, and E-site tRNAs at 2.60A resolution; P-site tRNA 6nd5 1y 74 2.6 RF00005 URS00005AA258_562 30733327 0030533 0006412 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[..)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with chloramphenicol and bound to mRNA and A-, P-, and E-site tRNAs at 2.60A resolution; A-site and E-site tRNAs 6nd5 2A 2800 2.6 RF02540,RF02541,RF00002 URS00001698E8_300852 30733327 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<....<<<<........>>>.>....>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<..>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<...<<......<<<<<<<<....>>>>>>>>...>>.............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>......>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<...>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((...))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...((((((((.....))))))))....{.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).))))....(((((((((.[.....)))))))))....}.(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....(())....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((.....((..........))......)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((....)))))))).))..........]]].)....))))))))))...)))))))(((((((..)))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((....))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((.((.(((((((((.(......[..(((((...((......((((((((....))))))))...))...........].)))))).))))))))).)).)))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))((((.))).....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))...)))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with chloramphenicol and bound to mRNA and A-, P-, and E-site tRNAs at 2.60A resolution; 23S Ribosomal RNA 6nd5 2B 120 2.6 RF00001 URS000080DEE8_300852 30733327 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<.....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>..>>>>>>>>>. .(((((((.((....((((((.(....(((((((...(.....)...))))..)))...).)))).))(((.......((((((((....)))))))).......))).)).))))))). Crystal structure of the Thermus thermophilus 70S ribosome in complex with chloramphenicol and bound to mRNA and A-, P-, and E-site tRNAs at 2.60A resolution; 5S Ribosomal RNA 6nd5 2a 1503 2.6 RF00177,RF01959,RF01960 URS000080DFED_300852 30733327 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggau .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<...<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>...>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<.....>>.....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>.........<.<<<<<<<........>>>>>>>>.........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((((((....)))))))....(........)....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}... Crystal structure of the Thermus thermophilus 70S ribosome in complex with chloramphenicol and bound to mRNA and A-, P-, and E-site tRNAs at 2.60A resolution; 16S Ribosomal RNA 6nd5 2v 13 2.6 30733327 10665 aaaaauguucuaa ............. ............. Crystal structure of the Thermus thermophilus 70S ribosome in complex with chloramphenicol and bound to mRNA and A-, P-, and E-site tRNAs at 2.60A resolution; mRNA 6nd5 2w 72 2.6 RF00005 URS00005AA258_562 30733327 0030533 0006412 562 cccgganagcucagggagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<..<<<<.....>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((...[.)))).((((.........))))......((((..]....)))).))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with chloramphenicol and bound to mRNA and A-, P-, and E-site tRNAs at 2.60A resolution; A-site and E-site tRNAs 6nd5 2x 76 2.6 RF00005 URS000041AF00_562 30733327 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with chloramphenicol and bound to mRNA and A-, P-, and E-site tRNAs at 2.60A resolution; P-site tRNA 6nd5 2y 73 2.6 RF00005 URS00005AA258_562 30733327 0030533 0006412 562 gcccgganagcucagggagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<.....>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[.)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with chloramphenicol and bound to mRNA and A-, P-, and E-site tRNAs at 2.60A resolution; A-site and E-site tRNAs 6nd6 1A 2871 2.85 RF02540,RF02541,RF00002 URS00001698E8_300852 30733327 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>....<<<<<.....<......>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<....<<<<........>>..>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..<...........>...>>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<.<<....>>.>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<...>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...((((((((.....))))))))....{.(((((((((..(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).))))....(((((((((.[.....)))))))))....}.(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((.(..(((..........)..)))..)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((..((.........))...))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((.(((((((((.(......[..(((((..(((......(((((.((....)).)))))...)))..........].)))))).))))))))).))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((...)))....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))...)))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with erythromycin and bound to mRNA and A-, P-, and E-site tRNAs at 2.85A resolution; 23S Ribosomal RNA 6nd6 1B 120 2.85 RF00001 URS000080DEE8_300852 30733327 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the Thermus thermophilus 70S ribosome in complex with erythromycin and bound to mRNA and A-, P-, and E-site tRNAs at 2.85A resolution; 5S Ribosomal RNA 6nd6 1a 1500 2.85 RF00177,RF01959,RF01960 URS000080DFED_300852 30733327 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>....<<<<.<<<<<....>>>>>.>>>>...<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<.<<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<......>>....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((((((....))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((...(((.(((....))).)))....(((....)))....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the Thermus thermophilus 70S ribosome in complex with erythromycin and bound to mRNA and A-, P-, and E-site tRNAs at 2.85A resolution; 16S Ribosomal RNA 6nd6 1v 13 2.85 30733327 10665 aaaaaugguuuuc ............. ............. Crystal structure of the Thermus thermophilus 70S ribosome in complex with erythromycin and bound to mRNA and A-, P-, and E-site tRNAs at 2.85A resolution; mRNA 6nd6 1w 73 2.85 RF00005 URS00003179F7_562 30733327 0030533 0006412 562 gggugaunagcucagggagagcaccucccunacnaggaggggnucggcggnucgaucccgucaucacccacca <<<<<<<..<<<<.....>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((....((((...[.)))).(((((.......))))).....(((((..]....)))))..))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with erythromycin and bound to mRNA and A-, P-, and E-site tRNAs at 2.85A resolution; A-site and E-site tRNAs 6nd6 1x 76 2.85 RF00005 URS000041AF00_562 30733327 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with erythromycin and bound to mRNA and A-, P-, and E-site tRNAs at 2.85A resolution; P-site tRNA 6nd6 1y 74 2.85 RF00005 URS00003179F7_562 30733327 0030533 0006412 562 gggugaunagcucaggggagagcaccucccunacnaggaggggnucggcggnucgaucccgucaucacccacca <<<<<<<..<<<<......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((....((((......)))).(((((.......))))).....(.(((.......))).)..))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with erythromycin and bound to mRNA and A-, P-, and E-site tRNAs at 2.85A resolution; A-site and E-site tRNAs 6nd6 2A 2800 2.85 RF02540,RF02541,RF00002 URS00001698E8_300852 30733327 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<........>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<..>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<..>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<...<<......<<<<<<<<<..>>>>>>>>>...>>.............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((...))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....(())....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..((((.((((...(((...(((((.((.(....................)..).))))))..)).)...)))).))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((.().)))))))).))..........]]].)....))))))))))...)))))))(.(((((..))))).)....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((....))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((.(((((((((.(.........(((((...((.......((((.((....)).))).)...)).............)))))).))))))))).))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..((((((((........)))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))((((.))).....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))...)))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with erythromycin and bound to mRNA and A-, P-, and E-site tRNAs at 2.85A resolution; 23S Ribosomal RNA 6nd6 2B 120 2.85 RF00001 URS000080DEE8_300852 30733327 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>. ..(((((((((....((((((.(....(((((((...(.....)...))))..)))...).)))).))(((.......((((((((....)))))))).......))).))))))))).. Crystal structure of the Thermus thermophilus 70S ribosome in complex with erythromycin and bound to mRNA and A-, P-, and E-site tRNAs at 2.85A resolution; 5S Ribosomal RNA 6nd6 2a 1503 2.85 RF00177,RF01959,RF01960 URS000080DFED_300852 30733327 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggau .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<.<<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<......>>....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...(((.....))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...(((((((.(...((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(..(((((((...)))))))..)...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.((((((...(...(((((((...(((((((....))))))).(.((((....)))).).)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).))))).....))))))).[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}... Crystal structure of the Thermus thermophilus 70S ribosome in complex with erythromycin and bound to mRNA and A-, P-, and E-site tRNAs at 2.85A resolution; 16S Ribosomal RNA 6nd6 2v 13 2.85 30733327 10665 aaaaaugguuuuc ............. ............. Crystal structure of the Thermus thermophilus 70S ribosome in complex with erythromycin and bound to mRNA and A-, P-, and E-site tRNAs at 2.85A resolution; mRNA 6nd6 2w 73 2.85 RF00005 URS00003179F7_562 30733327 0030533 0006412 562 gggugaunagcucagggagagcaccucccunacnaggaggggnucggcggnucgaucccgucaucacccacca <<<<<<...<<<<.....>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>.>>>>>>.... (((((....((((...[.)))).(((((.......))))).....(((((..]....)))))..))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with erythromycin and bound to mRNA and A-, P-, and E-site tRNAs at 2.85A resolution; A-site and E-site tRNAs 6nd6 2x 76 2.85 RF00005 URS000041AF00_562 30733327 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(.(((..]....))).)))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with erythromycin and bound to mRNA and A-, P-, and E-site tRNAs at 2.85A resolution; P-site tRNA 6nd6 2y 73 2.85 RF00005 URS00003179F7_562 30733327 0030533 0006412 562 gggugaunagcucagggagagcaccucccunacnaggaggggnucggcggnucgaucccgucaucacccacca <<<<<....<<<<.....>>>>.<<<<<.......>>>>>......<<<<.......>>>>...>>>>>.... (((((.(..((((...[.)))).(((((.......))))).......(((..]....)))..).))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with erythromycin and bound to mRNA and A-, P-, and E-site tRNAs at 2.85A resolution; A-site and E-site tRNAs 6ndk QA 1500 3.64 RF00177,RF01959,RF01960 URS000080DFED_300852 30782843 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>....<<<<.<<<<<....>>>>>.>>>>...<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>..>>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<........>>..>>>>>>>>.<<<.<<<..<<<<<........<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>..........>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>..... ......(((....[[[..)))...(((.(((((..(((((((((....(((.(((..(((..((.((((.(((()))).)))).)))))......(((......((((((((..((...(((((((.(((((....((((.(....).)))).....)))))....((((.(..((....))..).))))...(((.....))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..))))))))...........((([[...(.((((....((.(((((.(.((((((((((......((((((.....))))))....))))))))..))).)))))..((((((((....((((((((....((((((....((........)).......))))))....).......((....)).)))))))...)))).)))..)))....))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((.(((...))).))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]]..((((...((((((.((..(((((..((((((.(........((........))..........(((((((..(...((((((....(((.(((....))).)))...(((......)))....)))))))..(.(((...((..((.(....((((((..(....).....(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...))))))).....(((((....)))))........)))).....).)..)....)).)))).....)))))))..[...).)))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))...........(((((((........))))))).......)..))))).....(((((((......]...)))))))......))...))))))..)).))..(....((...((((...(..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..)...))))....))......)..(((.(((((....))))).)))}.... Structure of ASLSufA6 A37.5 bound to the 70S A site; 16S rRNA 6ndk QV 77 3.64 RF00005 URS000041AF00_562 30782843 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..(((.......[...))).(((((.......))))).....(((((..]....)))))))))))..... Structure of ASLSufA6 A37.5 bound to the 70S A site; P-site tRNAfMet 6ndk QY 14 3.64 URS0000E60B7D_90371 30782843 90371 ucguucgggaacga ..<........>.. ..(........).. Structure of ASLSufA6 A37.5 bound to the 70S A site; A-site ASLSufA6 A37.5 6ndk RA 2870 3.64 RF02540,RF02541,RF00002 URS00001698E8_300852 30782843 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>....<<<<<.....<......>......>>>>>.....<.....<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>..>>>....>.>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<.......>>>....<<..>>...>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<....<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.....>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..<<<.......>>>...>>>.........<........>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<..>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<.<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>..>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<.............>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> .(.......((((((((((.....(((..((((((((..((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((.((((.....)))).)))....(.(((((((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....((((((((..[......))))))))....)..((((].[[[[))))...))).........)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((.(((((((..(((...(((.....)))...)))...((....))..(.((.....)).)....((..))...))))))).)))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((.([..(((((((((...((....(((.((((...((.(((......)))..))...)))).)))...).)...)))))))))..).]))))))).)...(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((.((.(........((((.(((..(((.......)))...))).....(...((......)).).))))....).)).))))).))..........]]].)....))))))))))...)))))))(.(((((..))))).)....))))))(((((((...(((......(((((.(((....))))))))...)))..))))).)).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((.(...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((....((.((((.(((((((.((.....)))))))))......)))).))...)))(....(((..)))......))))))...)))..)))))(..).....))))...)....))))))))))))))).)))......(......)..)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((.(((((.(.((((.(.........(((((..(((......((((((((....))))))))...)))............)))))).))))..)))))).)))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].]......(.(((..((..]]]]..)).))).)......)}......))))..))))))......(((((.(.((..((...((.......))...))..))...)))).).).....(((((.((((((..((((((.((......)).)))..))).(((((.....))))).....)))))..)...))).))....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((.(((.}}.))).))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))((.(.).).....(((((((((.......)))))....(((.((((.(((.....((((....))))....)))..))))..)))...))))...).). Structure of ASLSufA6 A37.5 bound to the 70S A site; 23S rRNA 6ndk RB 120 3.64 RF00001 URS00005F2F4B_300852 30782843 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<........<<<<<<<....>>>>>>>........>>>.>>>>>>>>>>. .((((((((((....((((((.(....((..((....(.....)....))....))...).)))).)).((.......(.((((((....)))))).).......))..)))))))))). Structure of ASLSufA6 A37.5 bound to the 70S A site; 5S rRNA 6ndk XA 1504 3.64 RF00177,RF01959,RF01960 URS000080DFED_300852 30782843 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<......>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.(((....(((.(((((((.(((((((.((......((((((.....))))))....)).)))))..)))))))))..((((((((....((((((((....((((((....((........)).......))))))....).......((....)).)))))))...)))).)))..))))....)))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].]((((..(((((((.((..(((.(..((((.(.(((......((........))..........(((((((..(...(((((((...(((((((....))))))).(..((......))..).)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).).).)))).(...((((((......(((..(((.((((....))))).))....)))......))))))......(....(((((((........)))))))....)..)..).))).....(((((((......]...)))))))......))...))))))).)).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((.(((((....))))).)))}.... Structure of ASLSufA6 A37.5 bound to the 70S A site; 16S rRNA 6ndk XV 77 3.64 RF00005 URS000041AF00_562 30782843 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<.........>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(.(.(..].....)).)))))))..... Structure of ASLSufA6 A37.5 bound to the 70S A site; P-site tRNAfMet 6ndk XX 11 3.64 30782843 562 aaaaugcccua ........... ........... Structure of ASLSufA6 A37.5 bound to the 70S A site; mRNA 6ndk XY 16 3.64 URS0000E60B7D_90371 30782843 90371 cucguucgggaacgag .<<<........>>>. ..((........)).. Structure of ASLSufA6 A37.5 bound to the 70S A site; A-site ASLSufA6 A37.5 6ndk YA 2870 3.64 RF02540,RF02541,RF00002 URS00001698E8_300852 30782843 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<....{[[..[[<<<<<<[[<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...(((....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>.]]...............<<....>>....]].........<<<<....>>>>.............}....>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<.......>>>....>>.........<........>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<..>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..((((...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.........<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<......>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<.(((..>>>>..)))>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))))>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> ((.......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...(((....(((.((((.....)).)))))....(.(((.(((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))..))).....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..(.((.....)).)....((..))...)))))))))))))..((.(...((((((.....((((((((((.((((....(((((......)))))....)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((.(((...(((...((..((((...((.(((......)))..))...))))..))..)).)...))).)))))..)..))))))).))..(((((((.((......)).)))))))......((......))....((((.(((...((([[[...(.((((((.....(.....((..((((((((((........((((.(.(..((.(......)))....)).....(...(........).).))))....)))))))))).))..........]]].)....))))))))))...)))))))(((((((())))))))....))))))(((((((...(((......(((((.(((....))))))))...)))..))))).)).....))))))(......((.....((((((.......))))))((((....((((..(...(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).).).....((......)).)))).((.((....)).))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..((.((((..(((...((...(((((....)))))...))...)))))))...)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((.((.((((..(((.(.........(((((..(((......(((((.((....)).)))))...)))............)))))).)))..)))).)).)))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....((((((..((..]]]]..)).)))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))((.(.).).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...).)) Structure of ASLSufA6 A37.5 bound to the 70S A site; 23S rRNA 6ndk YB 120 3.64 RF00001 URS00005F2F4B_300852 30782843 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> .((((((.(((....((((((((....(((((.....(.....).....))..)))...)))))).))(((.......(.((((((....)))))).).......))).))).)))))). Structure of ASLSufA6 A37.5 bound to the 70S A site; 5S rRNA 6nit C 18 3.8 URS000036142B_9606 31353209 9606 uggagugugaaugguguu .................. .................. Human Argonaute2-miR-122 bound to a target RNA with four central mismatches (bu4); RNA (5'-R(P*UP*GP*GP*AP*GP*UP*GP*UP*GP*AP*CP*AP*AP*UP*GP*GP*UP*GP*UP*UP*U)-3') 6nit D 13 3.8 URS000036142B_9606 31353209 9606 uggagugugaugg ............. ............. Human Argonaute2-miR-122 bound to a target RNA with four central mismatches (bu4); RNA (5'-R(P*UP*GP*GP*AP*GP*UP*GP*UP*GP*AP*CP*AP*AP*UP*GP*GP*UP*GP*UP*UP*U)-3') 6nit E 21 3.8 URS0000EEACE8_32630 31353209 32630 aacaccauccaacacuccaaa ..................... ..................... Human Argonaute2-miR-122 bound to a target RNA with four central mismatches (bu4); RNA (5'-R(P*AP*AP*CP*AP*CP*CP*AP*UP*CP*CP*AP*AP*CP*AP*CP*UP*CP*CP*AP*AP*A)-3') 6nit F 20 3.8 URS0000EEACE8_32630 31353209 32630 aacaccgccaacacuccaaa .................... .................... Human Argonaute2-miR-122 bound to a target RNA with four central mismatches (bu4); RNA (5'-R(P*AP*AP*CP*AP*CP*CP*AP*UP*CP*CP*AP*AP*CP*AP*CP*UP*CP*CP*AP*AP*A)-3') 6nsh RA 2881 3.397 RF02540,RF02541,RF00002 URS00001698E8_300852 33016876 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu .<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<..>...>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..<<<.......>>>...>>>.........<........>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<..............<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>.....>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<<.....>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>. .((......((((((((((.....(((..((((((((((((......((((((.[[..[[[)))...].((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....(())...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((...((((((......)))).))...))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((.(.(.......(((((.(((..(((.......)))...))).....(...(........).).)))))...).).)))))).))..........]]].)....))))))))))...)))))))(((((((.......)))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....((((..(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((....)))).....))))))...)))...))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((.(.(((((..(((.(.............(..(((......(.((.(((....))).)).)...)))............)....).)))..)))).)).)))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(..(((.....))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...))). Modified ASL proline bound to Thermus thermophilus 70S (near-cognate); 23S rRNA 6nsh RB 120 3.397 RF00001 URS00005F2F4B_300852 33016876 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).)))))))))). Modified ASL proline bound to Thermus thermophilus 70S (near-cognate); 5S rRNA 6nsh QA 1511 3.397 RF00177,RF01959,RF01960 URS000080DFED_300852 33016876 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggggucuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucaccuccuuu ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<...>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>.....<......>....>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.............. ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((.(.(((((...))))).).))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((......(((((.((..(((.(((....))).)))....(((....)))...)).)))))..((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((.......(((.....)))......))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}............. Modified ASL proline bound to Thermus thermophilus 70S (near-cognate); 16S rRNA 6nsh QV 17 3.397 URS00021ED980_562 33016876 562 cuucguucggnacgaag <<<<<<.....>>>>>> (((((.......))))) Modified ASL proline bound to Thermus thermophilus 70S (near-cognate); P-site ASLPro 6nsh QX 18 3.397 33016876 562 gcaaggagguaaaacccu .................. .................. Modified ASL proline bound to Thermus thermophilus 70S (near-cognate); mRNA 6nsh YA 2883 3.397 RF02540,RF02541,RF00002 URS00001698E8_300852 33016876 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<..>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<..>...>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<.<<<......>>>..>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<..<...<<<<.......>>>>...>..........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<<..>>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<.<<...<<......<<<<<.<<....>>.>>>>>...>>.............>>.>>..>>>>.>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<<.....>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((..)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((.((((.....)))).)))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....(())...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((...(((.((......)).).))...))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((........((((..(...((...........))...)......(...((......)).).))))....)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(....(((....)))......))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((.((.((...(((............(...(...........(((((.((....)).)))))..................)...)...)))...)).)).)))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(..(((.....))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Modified ASL proline bound to Thermus thermophilus 70S (near-cognate); 23S rRNA 6nsh YB 120 3.397 RF00001 URS00005F2F4B_300852 33016876 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).)))))))))). Modified ASL proline bound to Thermus thermophilus 70S (near-cognate); 5S rRNA 6nsh XA 1511 3.397 RF00177,RF01959,RF01960 URS000080DFED_300852 33016876 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggggacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucaccuccuuu ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<...>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>....<<<<.<<.<<....>>.>>.>>>>...<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<.<.....>>>..>>>>>>>>.<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.............. ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(.(..((.((((((((.(.).)))))))).))).)......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.((.((.....)))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((....(..(((.(((....))).)))...(.((.....)))..)....)))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.((((((........(((.....))).......)))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}............. Modified ASL proline bound to Thermus thermophilus 70S (near-cognate); 16S rRNA 6nsh XV 15 3.397 URS00021ED980_562 33016876 562 uucguucggnacgaa <<<<<.....>>>>> .(((.......))). Modified ASL proline bound to Thermus thermophilus 70S (near-cognate); P-site ASLPro 6nsh XX 19 3.397 33016876 562 ggcaaggagguaaaacccu ................... ................... Modified ASL proline bound to Thermus thermophilus 70S (near-cognate); mRNA 6nta QA 1500 3.1 RF00177,RF01959,RF01960 URS000080DFED_300852 33016876 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggggucuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<...>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<.<<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>.....<......>....>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<...<<<.....>>>.>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[..[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((.(((((((......((((((.....))))))....)))))))...)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]..](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((......((((((((..(((.(((....))).))).....((....))....))))))))..((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.((((((........(((.....))).......)))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Modified ASL proline bound to Thermus thermophilus 70S (cognate); 16S rRNA 6nta QV 17 3.1 URS00021ED980_562 33016876 562 cuucguucggnacgaag <<<<<<.....>>>>>> (((((.......))))) Modified ASL proline bound to Thermus thermophilus 70S (cognate); P-site ASLPro 6nta QX 10 3.1 33016876 562 guaaaaccgg .......... .......... Modified ASL proline bound to Thermus thermophilus 70S (cognate); mRNA 6nta RA 2881 3.1 RF02540,RF02541,RF00002 URS00001698E8_300852 33016876 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu .<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<..>...>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<....<<<<<......>>>>.>....>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..<<<.......>>>...>>>.......<............>.>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<..............<<..<<<......<<.<<<<<<..>>>>>>.>>...>>>............>>.....>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<<.....>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>. .((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....(())...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((....(((((......)))).)....)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((.(.......(((((.(((..(((.......)))...))).....(...(........).).)))))...).)))))))).))..........]]].)....))))))))))...)))))))(((((((.......)))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((((.((((.(..........(.((..((.......(..(((((....)))))..)....))............))..)).)))).)))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(...((.....))......(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))...))). Modified ASL proline bound to Thermus thermophilus 70S (cognate); 23S rRNA 6nta RB 120 3.1 RF00001 URS00005F2F4B_300852 33016876 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).)))))))))). Modified ASL proline bound to Thermus thermophilus 70S (cognate); 5S rRNA 6nta XA 1500 3.1 RF00177,RF01959,RF01960 URS000080DFED_300852 33016876 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggggacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<...>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>....<<<<.<<.<<.....>>>>.>>>>...<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<......>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<.<<<<..<<<<<<<....>>>>>>>...<<.<.....>>>..>>>>.>>>.<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((.(.).)))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.((.((.....)))).))))...(((.....))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).(((.(...))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((.(((((......((........))..........(((((((..(...(((..(.(..(((((((....)))))))...((.(.....)))..)..).)))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((.......(((.....)))......))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).))).)))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Modified ASL proline bound to Thermus thermophilus 70S (cognate); 16S rRNA 6nta XV 15 3.1 URS00021ED980_562 33016876 562 uucguucggnacgaa <<<<<.....>>>>> .(((.......)).) Modified ASL proline bound to Thermus thermophilus 70S (cognate); P-site ASLPro 6nta XX 12 3.1 33016876 562 agguaaaaccgg ............ ............ Modified ASL proline bound to Thermus thermophilus 70S (cognate); mRNA 6nta YA 2883 3.1 RF02540,RF02541,RF00002 URS00001698E8_300852 33016876 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu 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Modified ASL proline bound to Thermus thermophilus 70S (cognate); 23S rRNA 6nta YB 120 3.1 RF00001 URS00005F2F4B_300852 33016876 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).)))))))))). Modified ASL proline bound to Thermus thermophilus 70S (cognate); 5S rRNA 6nu2 A 1472 3.9 RF02541,RF02540 URS0000E60BD0_9606 30962385 0003735 0005840 9606 gcuaaaccuagccccaaacccacuccaccuuacuaccagcaaccuuagccaaaccauuuacauaaaguauaggcgauagaaauuguggcgcaauagauauaguaccgcaagggaaagaugaaaaauuauaaccaagcauaauauagcaaggacuaaccccuauaccuucugcauaaugaauuaacuagaaauaacuuugcaaggagagccaaagcuaagacccccgaaaccagacgagcuaccuaagaacagcuaagagcacacccgucuauguagcaaaauagugggaagauuuauagguagaggcgacaaaccuaccgagccuggugauagcugguuguccaagauagaaucuuaguucaacuuuaaauuugcccacagaaccaaauccccuuguaaauuuaacuguuaguccaaagaggaacagcucuuuggacacuaggaaaaaaccuuguagagagaguaaaaaauuuaacacccauaguaggccuaaaagcagccaccaauuaagaaagcguucaagcucaacaccaaaaaucccaaacauauaacugaacuccucacacccaauuggaccaaucuaucacccuauagaagaacuaauguuaguauaaguaacaugaaaacauucuccuccgcauaagccugcgucagaucacacugacaauuaacagcccaauaucuacaaucaaccaacaagucauuauuacccucacugucaacccaacacaggcaugcucauaaggaaagguuaaaaaaaguaaaaggaacucggcaaaucuuaccccgccuguuuaccaaaaacaucaccucuagcaucaccaguauuagaggcaccgccugcccagugacacauguuuaacggccgcgguuaaccgugcaaagguagcauaaucacuuguuccuuaaauagggaccuguaugaauggcuccacgaggguucagcugucucuuacuuuuaaccagugaaauugaccugcccgugaagaggcgggcauaacacagcaagacgagaagacccuauggagcuuuaauuuauuaaugcaaacaguaaccugcauuaaaaauuucgguuggggcgaccucggagcagaacccaaccuccgagcaguacaugcuaagacuucaccagucaaagcgaaccucaauugauccaauaacuugaccaacggaacaaguuacccuagggauaacagcgcaauccuauucuagaguccauaucaacaauaggguuuacgaccucgauguuggaucaggacaucccgauggugcagccgcuauuaaagguucguuuguucaacgauuaaaguccuacgugaucugaguucagaccggaguaauccaggucgguuucuaucuacuuuauuccucccuguacgaaaggacaagagaaauaaggccuacuucacaaagcgccuucccccguaaaugauaucaucucaacuuagauacccacacccaagaacaggguu <<<.......<<<<....................................<......>...........<<.....>>........>>.>>.............<<....>>......................>>>...........<<<.......>>>...<.<........>.>.<<<<<<.........<<<.<<..<<....>>...>>.>>>...<<.<...<<<<.<.....<<<<<.<<<..<<<...>>>...<<<..<<<<........>>>>.>>>....>>>.>>>>>...<<.......>>......>.>>>>......>.>>..<<<<<<....<<<<....>>>><<<.<<<<<<<<<<.....<<......>>.....>>>>>>>>>>..>>>.<<<<<<<<<<......>>>>>>>>>>.<.<<<......>>>.>..<<<.<<<...<..............<....<<<.........>>>....>.......<<<......>>>...........................>...>>>>>>........>>>>>>...<<<<<......>>>>>.........>>>>>>.......<<..<<<....>>><<<<..<<<<........<<<<<......>>>>>......<<<...<<<<.......................>>>>.......>>>.....<<......>>.>>>>.....>>>>..<<<<...<<<<<<<<.<<................<<<<<<..<<<.........>>>...<<<<<<.............>>>>>>....<<<.<<<..<<<<<....>>>..>>>>><<<<<....>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>....>>.>>>>........>>.>>>>>>>>>>>>.>>...........<<<<<........>>>>>.......<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<..........>>>>>>>>>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<.....<<<..<<<<.....>>>>..>>>....>>.........<<<....>>>............>>>>..>>>>>>.......<<<..<.<<<<<<...<<.......>>...>>>>>>...>.>>.>.......<<<<<.<<<<<<..<<.<<<<<<......>>>>>>...>>.<<<<<.....>>>>>.....>>>>>..>...>>>>.>....<<<<<<<....>>>.>>>>....>>..>>>.>>..<<<.<<<.................>>>.>>><<<<<...<<<....>>>.>>>>>......<<<................>>>.........<<<<.......>>>>. ((.....(..((((....................................(...[..).....(.....((.]...))....)...)).)).............((....))....).....(...)........)).........(.(((.......))).[.(.(........).).(.((((.........(((.((..(......)...)).)))...((.(...((((.(.....(((((.((((.(((..[)))...(((..((((.......{)))).)))..).))).))))).(.((.......))...)..).))))......).))..((((((....((((....)))).((.((((((((((.....((......)).....))))))))))..))..((((((((((......))))))))))...(((......)))....(((.(((...(..............(.(..(((.........)))..).)....(..(((......))))..........................)...))))))........))))))...(((((......))))).........)))).)(......((..(((....)))(((...((((......(.(((((......)))))......(((...((((...............(..)....)))).......))).)...((......)).))))......)))..(((((...(((((((.((..(....(........((((((.].((.........))....((((((.............))))))....(((.(((..(((((....)))..)))))(((((....)))))........((..........((.((.......)).))..)..)....)))....)).))))....)..))).)))))))))))).)).....)).{..(((((.....]}.))))).......((..(((.((......((((.((((((..(((((.((((((((..........)))))))))))))..(((......[)))((((((..........]))))))(.((.....((...(((....[..)))...))....)).........(((....))).....)].....))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..((.((((((......))))))...)).(((((.....))))).....)))))..)...))..).....(((((((....))).))))..}.))..))).))..(((.(((......(....).....))).)))(((((...(((....))).)))))......(((................))).........((((.......)))). Structural insights into unique features of the human mitochondrial ribosome recycling; 16S rRNA 6nu2 AA 923 3.9 RF00177 URS0000E60B73_9606 30962385 0003735 0005840 9606 auagguuugguccuagccuuucuauuagcucuuaguaagauuacacaugcaagcauccccguuccagugaguucacccucuaaaucgaucaaaaggaacaagcaucaagcacgcagcaaugcagcucaaaacgcuuagccuagccacacccccacgggaaacagcagugauuaaccuuuagcaauaaacgaaaguuuaacuaagcuauacuaaccccaggguuggucaauuucgugccagccaccgcggucacacgauuaacccaagucaauagaccggcguaaagaguguuuuagaucacaauaaagcuaaaacucaccugaguuguaaaaaacuccaguugacacaaaauagacuacgaaaguggcuuuaacauaucugaacacacaauagcuaagacccaaacugggauuagauaccccacuaugcuuagcccuaaaccucaacaguucaacaaaacugcucgccagaacacuacgagccacagcuuaaaacucaaaggaccuggcggugcuucauaucccucuagaggagccuguucuguaaucgauaaaccccgaucaaccucaccaccucuugcucagccuauauaccgccaucuucagcaaacccugaugaaggcuacaaaguaagcgcaaguacccacguaaagacguuaggucaagguguagcccaugagguggcaagaaaugggcuacauuuucuaccccagaaacgauagcccuuaugaaauaagggucgaagguggauuuagcaguaaacuaagaguagagugcuuaguugaacagggcccugaagcgcguacacaccgcccgucacccuccucaaguauacuucaaaggacuuaacuaaaaccccuacgcauuuauauagaggagacgucguaacaugguaaguguacuggaaagugcacuuggacgaac ..((((..<<<<<<.)))).<<<<<<.<...<<<<<<<<....<<<.<<<..<......>......<<........<<<.<..<<..>>.>..>>>...<<<<....<<<..<<<....>>>.>>>......>>>>.<<...>>.>>.<<<....>>>.....>>>>>>......<<.<<<....<<<<....>>>>..>>>>>>>.>>>>>>.....<<<<<<<<.....(((.....((.>>>)).......)))..>>>>>...>.>>>>>>..<<<((.....<<<<..<<<<......<<<<<<......<<<.<<<.<<<......>>>..>>>.>>>.............<<....>>.>>>>>>.....>>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<.<<<<<..))..>>>>>.>.>>>.<<.......<<<<....>>>>.....>>..>>>>>><<<<<.<<<<<<<...<<<.<<<<...<<<<<<<<........<........>...........<<<<<<<.......<<.<<<...<<<<<.......<<..<<<<<.....>>>.......>>..>>.....<<<....>>>.........>>>...>>.>>>>>....>>>>>>>.....>>>>>>>>......<<<.....>>>........<<<.<.......>.>>>............>>>>.....<<<<<<<.........>>>>>>>.....>>>...>>>>>>>>>>.>>....<..<<.....<<<<<<..<<<<<......<<...<.......>....>>.......>>>>>.>>>>>>....>>...>.....<<<<<<<<<....>>>>>>>>>........ [.[[[...(((((...]]]]((((((.((..((((((((..(.(((.(((..(......)......(((.......(((.(...(())..)..)))...((((....((..((((....))).)))......)))).((...))))).(((....))).....)))))))......(.(((...(((((....)))).))))).)).)))))).....((((([[[.....(((.....((.]]])).......)))..)))))..).)))))))..((([[...(.((((...(((......((((((......(((.(((.((........))..))).)))...........(.((....))))))))).....)))....))))....((((((...((...((((.........))))...))))))))......{...(.(((((..]]..))))).))))).((........(((....)))......))...)))))((.((.(((((((...(((.(((((..((((..(((......((........))..........(((((((.......((.((....((((((.(....((..(((((.....))).......))..)).....(((....))).....).).)))...))..))))....)))))))...).))..)))).(....(((.....)))........((((.(.....).))))........)..))))).....(((((((.........))))))).....)))...)))))))))..))..(.(..((.(...((((((..(((((..((...((..((.....))...))...).)..))))).))))))..).))...)..)..(((((.(((....))).)))))}....... Structural insights into unique features of the human mitochondrial ribosome recycling; 12S rRNA 6nu3 A 1472 4.4 RF02541,RF02540 URS0000E60BD0_9606 30962385 0003735 0005840 9606 gcuaaaccuagccccaaacccacuccaccuuacuaccagcaaccuuagccaaaccauuuacauaaaguauaggcgauagaaauuguggcgcaauagauauaguaccgcaagggaaagaugaaaaauuauaaccaagcauaauauagcaaggacuaaccccuauaccuucugcauaaugaauuaacuagaaauaacuuugcaaggagagccaaagcuaagacccccgaaaccagacgagcuaccuaagaacagcuaagagcacacccgucuauguagcaaaauagugggaagauuuauagguagaggcgacaaaccuaccgagccuggugauagcugguuguccaagauagaaucuuaguucaacuuuaaauuugcccacagaaccaaauccccuuguaaauuuaacuguuaguccaaagaggaacagcucuuuggacacuaggaaaaaaccuuguagagagaguaaaaaauuuaacacccauaguaggccuaaaagcagccaccaauuaagaaagcguucaagcucaacaccaaaaaucccaaacauauaacugaacuccucacacccaauuggaccaaucuaucacccuauagaagaacuaauguuaguauaaguaacaugaaaacauucuccuccgcauaagccugcgucagaucacacugacaauuaacagcccaauaucuacaaucaaccaacaagucauuauuacccucacugucaacccaacacaggcaugcucauaaggaaagguuaaaaaaaguaaaaggaacucggcaaaucuuaccccgccuguuuaccaaaaacaucaccucuagcaucaccaguauuagaggcaccgccugcccagugacacauguuuaacggccgcgguuaaccgugcaaagguagcauaaucacuuguuccuuaaauagggaccuguaugaauggcuccacgaggguucagcugucucuuacuuuuaaccagugaaauugaccugcccgugaagaggcgggcauaacacagcaagacgagaagacccuauggagcuuuaauuuauuaaugcaaacaguaaccugcauuaaaaauuucgguuggggcgaccucggagcagaacccaaccuccgagcaguacaugcuaagacuucaccagucaaagcgaaccucaauugauccaauaacuugaccaacggaacaaguuacccuagggauaacagcgcaauccuauucuagaguccauaucaacaauaggguuuacgaccucgauguuggaucaggacaucccgauggugcagccgcuauuaaagguucguuuguucaacgauuaaaguccuacgugaucugaguucagaccggaguaauccaggucgguuucuaucuacuuuauuccucccuguacgaaaggacaagagaaauaaggccuacuucacaaagcgccuucccccguaaaugauaucaucucaacuuagauacccacacccaagaacaggguu <<<.......<<<<....................................<<....>>.....<.....<<.....>>....>...>>.>>.............<<....>>......................>>>...........<<<.......>>>...<............>.<<<<<<.........<<<.<<..<<....>>...>>.>>>...<<.<..<<<<<.<.....<<<<<.<<<..<<<...>>>...<<<..<<<<........>>>>.>>>....>>>.>>>>>...<<.......>>......>.>>>>...>..>.>>..<<<<<<....<<<<....>>>>.<<.<<<<<<<.<<.....<<......>>.....>>.>>>>>>>..>>..<<<<<<<<<<......>>>>>>>>>>.<.<<<......>>>.>..<<<.<<<...<..............<....<<<.........>>>....>.......<<<......>>>...........................>...>>>>>>........>>>>>>...<<<<<......>>>>>.........>>>>>><......<<..<<<....>>><<<...<<<<........<<<<<......>>>>>......<<<...<<<<.......................>>>>.......>>>.....<<......>>.>>>>......>>>..<<<<...<<<<<<<<.<<................<<<<<<..<<<.........>>>...<<<<<<.............>>>>>>....<<<.<<<..<<<<<....>>>..>>>>><<<<<....>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>....>>.>>>>........>>.>>>>>>>>>>>>.>>.....>.....<<<<<........>>>>>.......<<..<<<.<<......<<<<.<<<<<...<<<<<.<<<<<<<<..........>>>>>>>>>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<.....<<<..<<<<.....>>>>..>>>....>>.........<<<....>>>.............>>>..>>>>>>.......<<<..<<<<<<<<...<<.......>>...>>>>>>>..>.>>.>.......<.<<<.<<<<<<..<<.<<<<<<......>>>>>>...>>.<<<<<.....>>>>>.....>>>>>..>...>>>..>....<<<<<<<....>>>.>>>>....>>..>>>.>>..<<<.<<<.................>>>.>>><<<<<...<<<....>>>.>>>>>......<<<................>>>.........<<<<.......>>>>. ((.....(..((((....................................(...[..).....(.....((.]...))....)...)).)).............((....))....).....(...)........)).........(.(((.......))).[.(.(........).).((((((.........((..((..((....))...)).).)...((.(...((((.(.....(((((.((((.(((..[)))...(((..((((.......{)))).)))..).))).))))).(.((.......))...)..).))))......).))..((((((....((((....)))).((..(((((.(((.....((......)).....)))).))).)..))..((((((((((......))))))))))...(((......)))....(((.(((...(..............(.(..(((.........)))..).)....(..(((......))))..........................)...))))))........))))))...(((((......))))).........))))))(......((..((......))(((...((((......(.(((((......)))))......(((...((((...............(..)....)))).......))).)...((......)).))))......)))..((((....(((((((.((..(....(........((((((.].((.........))....((((((.............))))))....(((.(((..(((((....)))..)))))(((((....)))))........((..........(((((.......)))))..)..)....)))....)).))))....)..))).))))))).)))).)).....)).{..(((((.....]}.))))).......((..(((.((......((((.(((((....((((.((((((((..........))))))))))))...(((......[)))((((((..........]))))))(.((.....(((..(((....[..)))..)))....)).........(((....))).....)]......)))..))))))......((((..(.((((((.(.((.......)))..))))))...).)).).)......((((.((((((..((.(((((........)))))...)).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..}.))..))).))..(((.(((......(....).....))).)))(((((...(((....))).)))))......(((................))).........((((.......)))). Structural insights into unique features of the human mitochondrial ribosome recycling; 16S rRNA 6nu3 AA 923 4.4 RF00177 URS0000E60B73_9606 30962385 0003735 0005840 9606 auagguuugguccuagccuuucuauuagcucuuaguaagauuacacaugcaagcauccccguuccagugaguucacccucuaaaucgaucaaaaggaacaagcaucaagcacgcagcaaugcagcucaaaacgcuuagccuagccacacccccacgggaaacagcagugauuaaccuuuagcaauaaacgaaaguuuaacuaagcuauacuaaccccaggguuggucaauuucgugccagccaccgcggucacacgauuaacccaagucaauagaccggcguaaagaguguuuuagaucacaauaaagcuaaaacucaccugaguuguaaaaaacuccaguugacacaaaauagacuacgaaaguggcuuuaacauaucugaacacacaauagcuaagacccaaacugggauuagauaccccacuaugcuuagcccuaaaccucaacaguucaacaaaacugcucgccagaacacuacgagccacagcuuaaaacucaaaggaccuggcggugcuucauaucccucuagaggagccuguucuguaaucgauaaaccccgaucaaccucaccaccucuugcucagccuauauaccgccaucuucagcaaacccugaugaaggcuacaaaguaagcgcaaguacccacguaaagacguuaggucaagguguagcccaugagguggcaagaaaugggcuacauuuucuaccccagaaacgauagcccuuaugaaauaagggucgaagguggauuuagcaguaaacuaagaguagagugcuuaguugaacagggcccugaagcgcguacacaccgcccgucacccuccucaaguauacuucaaaggacuuaacuaaaaccccuacgcauuuauauagaggagacgucguaacaugguaaguguacuggaaagugcacuuggacgaac ..((((..<<<<<<.)))).<<<<<<.<...<<<<<<<<..<.<<<.<<<..<......>......<<........<<<....<<..>>....>>>...<<<<....<<<..<<<....>>>.>>>......>>>>.<<...>>.>>.<<<....>>>.....>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>.....<<<<<<<<.....(((.....((.>>>)).......)))..>>>>>...>.>>>>>>..<<<((......<<<..<<<<......<<<<<<........<...<.<<........>>..>...>...............<<....>>.>>>>>>.....>>>>...>>>....<<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..>.......<.<<<<<..))..>>>>>.>.>>>.<<.......<<<<....>>>>.....>>..>>>>>><<<<<.<<<<<<<...<<<.<<<<<..<<<<<<<.<<.....<<........>>..........<<<<<<<.......<<.<<<..<<<<<<.......<<..<<<<<.....>>>.......>>..>>.....<<<....>>>.........>>>...>>>>>>>>....>>>>>>>..>>..>>>>>>>.......<<.....>>...<....<<<<<<.......>>>>>>....>.....>>>>>.....<<<<<<<.........>>>>>>>.....>>>...>>>>>>>>>>.>>........<.....<<<<<<...<<<<...........<.......>.............>>>>..>>>>>>....>..........<<<<<<<<<....>>>>>>>>>........ [.[[[[..(((((..]]]]]((((((.((..((((((((..(.(((.(((..(......)......(((.......(((....((()))....)))...((((....((..((((....))).)))......)))).((...))))).(((....))).....)))))))......(.(((...(((((....)))).))))).)).)))))).....((((([[[.....(((.....((.]]])).......)))..)))))..)).))))))..((([[...(.((((...(((......(((((((......((.(((.((........))..))).))......).....(.((....))))))))).....)))....))))....((((((...((....(((.........)))....))))))))......{...(.(((((..]]..))))).))))).(.(......((((....)))).....))...)))))((.((.(((((((...(((.(((.(..((((((.(((.....((........))..........(((((((.......((.((....((.(((.(....((..(((((.....))).......))..)).....(((....)).)....).).))....))..))))....)))))))..))..))))))).(...(.((.....)).).(....(((((((.....)))))))....)..)..).))).....(((((((.........))))))).....)))...)))))))))..))..(.(...(.(...((((((...((((..((..(.(..((.....))...).)..).)..))))..))))))..).)....)..)..(((((((((....)))))))))}....... Structural insights into unique features of the human mitochondrial ribosome recycling; 12S rRNA 6nud H 40 3.5 URS0000E60BD8_1308 30814678 1308 acggaaacuuucguaacuguuuaauucuguucacuuauuc ........................................ ........................................ Small conformation of ssRNA-bound CRISPR_Csm complex; crRNA 6nud U 28 3.5 URS0000E60BC0_1308 30814678 1308 aagugaacagaauuaaacaguuacgaaa ............................ ............................ Small conformation of ssRNA-bound CRISPR_Csm complex; target ssRNA 6nuo QA 1500 3.2 RF00177,RF01959,RF01960 URS000080DFED_300852 33016876 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggggucuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<...>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>.....<......>....>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<....<<.....>>..>....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((.(.((((((((((......((((((.....))))))....))))))))..))).)))))..(((((((((....(((((((....((((((....((........)).......))))))....).......((....)).))))))...))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((.(.(((((...))))).).))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((......(((((..(..(((.(((....))).))).................)..)))))..((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((..(((((.........((.....))........)))))......(((((....)))))........)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((..........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Modified tRNA(Pro) bound to Thermus thermophilus 70S (cognate); 16S rRNA 6nuo QV 77 3.2 RF00005 URS00001DEEBE_562 33016876 0030533 0006412 562 cggugauuggcgcagccugguagcgcacuucguucggnacgaaggggucggagguucgaauccucuaucaccgacca <<<<<<...<<<<.........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>.>>>>>>.... (((((((..((((.........)))).(.(((.......))).).....(((((.......)))))))))))).... Modified tRNA(Pro) bound to Thermus thermophilus 70S (cognate); P-site tRNA-Pro 6nuo QX 19 3.2 33016876 562 ggcaaggagguaaaaccgg ................... ................... Modified tRNA(Pro) bound to Thermus thermophilus 70S (cognate); mRNA 6nuo RA 2881 3.2 RF02540,RF02541,RF00002 URS00001698E8_300852 33016876 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu .<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<..>...>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..<<<.......>>>...>>>.......<.<........>.>.>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<.<....<<<<..............<<...<.......<<<<<<<<<..>>>>>>>>>....>.............>>.....>>>>....>.>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<<.....>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>. .((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....(())...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((....((((........))).)....))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((.(.......(((((.(((..(((.......)))...))).....(...((......)).).)))))...).)))))))).))..........]]].)....))))))))))...)))))))(((((((.......)))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((.((.((((.((.....)))))).))......))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((.(...(....((.............(..(..(((......(..(((((....)))))..)...)))............)..)...).).....)..).)))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....((.((((.((..]]]]..)))))).)).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(..(((.....))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...))). Modified tRNA(Pro) bound to Thermus thermophilus 70S (cognate); 23S rRNA 6nuo RB 120 3.2 RF00001 URS00005F2F4B_300852 33016876 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> (((((((((((....((((((.(....((((((....(.....)....)))..)))...).)))).))(((.......((.(((((....))))).)).......))).))))))))))) Modified tRNA(Pro) bound to Thermus thermophilus 70S (cognate); 5S rRNA 6nuo XA 1500 3.2 RF00177,RF01959,RF01960 URS000080DFED_300852 33016876 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggggacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<...>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<..<..<<<<<<<....>>>>>>>...<<.<.....>>>...>.>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(.((((((.(.).)))))).).)))))......(((......((((((((..((...(((((((.(((((....((((.(....).)))).....)))))....((((.(((.(.....)))).))))...(((.....))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).(((.(...))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((.(.(((...))).).))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((.(((((......((........))........(.(((((((..(...((((.(.(..(((((((....)))))))...(.((.....)))..)..)))))).((.((....((((((.(....(((((((((....)))...(((......)))...)))))).....((((.((((((........(((.....))).......)))))).....(((((....)))))........)))).....).).)))...))..))))....)))))))).[)).))).)))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Modified tRNA(Pro) bound to Thermus thermophilus 70S (cognate); 16S rRNA 6nuo XV 77 3.2 RF00005 URS00001DEEBE_562 33016876 0030533 0006412 562 cggugauuggcgcagccugguagcgcacuucguucggnacgaaggggucggagguucgaauccucuaucaccgacca <<<<<<<..<<<<.........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((......[..)))).(((((.......)))))......((((..]....)))).))))))).... Modified tRNA(Pro) bound to Thermus thermophilus 70S (cognate); P-site tRNA-Pro 6nuo XX 19 3.2 33016876 562 ggcaaggagguaaaaccgg ................... ................... Modified tRNA(Pro) bound to Thermus thermophilus 70S (cognate); mRNA 6nuo YA 2883 3.2 RF02540,RF02541,RF00002 URS00001698E8_300852 33016876 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<..>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<..>...>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<<..>>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<....<<<............<<.<<...<.......<<<<<<<<....>>>>>>>>....>.............>>.>>...>>>....>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<<.....>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((..)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...((((((((.....))))))))....{.(((((((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).))))....(((((((((.[.....)))))))))....}.(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....(..)...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((.(.(((.((......)).).)))..))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((........((((..((..((...........))..))......(...((......)).).))))....)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((.(...(....((................(....(......((((((((....))))))))....).............)......).)....)...).)))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(..(((.....))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Modified tRNA(Pro) bound to Thermus thermophilus 70S (cognate); 23S rRNA 6nuo YB 120 3.2 RF00001 URS00005F2F4B_300852 33016876 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga ..<<<<.........<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><.<..<<...<<.<<..<.....>..>>.>>....>>.>.>......>>>>. ..((((....(....((((((((....(((((((...(.....)...))))..)))...)))))).))..(.......((..(..(.....)..)..)).......)...)....)))). Modified tRNA(Pro) bound to Thermus thermophilus 70S (cognate); 5S rRNA 6nwy QA 1511 3.5 RF00177,RF01959,RF01960 URS000080DFED_300852 33016876 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggggucuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucaccuccuuu ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<...>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>....<<<<.<<<<<....>>>>>.>>>>...<<<.....>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<.<<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<....<<<......>>>.......>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<...<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<......>>>..>>>>>>>>.<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>......>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.............. ....((((....[[[..)))).((((.(((((..(((((((((....(((.(((..(.(..((.((((((((((.)))))))))).))).)......(((......((((((((..((...(((((((.(((((....((((((....)))))).....))))).....(((....((.....))...)))....((.(...).)).)))))))..))))))))))(((....((...((((((((.......)))))))).))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(.(((....)))..))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((.(((((((......((((((.....))))))....)))))))...)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((....(...((((.........))))...).))))))......{...((((((..((.(((((.......))))).))...((..]])).....)))))))))).(((......((((....))))....)))...]]]..(((((.(((((((.((..(((....((((.(((((......((........))..........(((((.((.(...((((..(...(((.(((....))).)))...((((....))))...)..))))).((.(((...((.(((.(....((((((.((....))....(((......)))...)))))).....((((.(((((.....(...(((.....)))).......)))))..(..(((((....))))).....)..)))).....).).))....)).)))))....)))))))...)).))).)))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(.....((((((........)))))).....)..)....))).....(((((((..........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}............. Modified tRNA(Pro) bound to Thermus thermophilus 70S (near-cognate); 16S rRNA 6nwy QV 77 3.5 RF00005 URS00001DEEBE_562 33016876 0030533 0006412 562 cggugauuggcgcagccugguagcgcacuucguucggnacgaaggggucggagguucgaauccucuaucaccgacca <<<<<<<..<<<<.........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.........)))).(((((.......))))).....(((((.......)))))))))))).... Modified tRNA(Pro) bound to Thermus thermophilus 70S (near-cognate); E-site tRNA-Pro 6nwy QX 19 3.5 33016876 562 ggcaaggagguaaaacccu ................... ................... Modified tRNA(Pro) bound to Thermus thermophilus 70S (near-cognate); mRNA 6nwy RA 2882 3.5 RF02540,RF02541,RF00002 URS00001698E8_300852 33016876 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>....<<<<<.....<......>......>>>>>.....<.....<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<.....<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>.>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>....>.>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<..>...>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<....<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.....>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..<<<<.......>>>>..>>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>...<<<.....>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[[)))...].((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))....(((((.....(...[..)......)))))...........(......)...(((((.....((.]...))....)))))...((((...((((((((.....))))))))....{.(((.(((((......(...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)..)))))..))))....(((((((((.[.....)))))))))....}.(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....(())...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((.(((...(((...((((((((.(.((.(((......)))..)))..))))))))..)).)...))).)))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(.((((((((.......(((((.(((..(((.........)))..))).....(...((......)).).)))))...)))))))).).))..........]]].)....))))))))))...)))))))(.((((((.....)))))).)....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]]((((((.((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((.(((((((.((.....)))))))))......))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...)))).)))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.(((((.....))))).))))))(...).......((((.((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).)).)))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((.(((((.((((((.(.........((.((..(((......((((((((....))))))))...)))............)).))).)))))).))))).)))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...((.((((.(.(((((.........)))))...).((][.[[[))....)))).))...((((..(((...{..)))..)))).(((....))).))]]].].....((.((((.((..]]]]..)))))).)).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(.(((((.....(....)....))))).).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(...(........).....(((((((((.......)))))....((((((((..((.....((((....))))....))...))))).)))...))))...)))) Modified tRNA(Pro) bound to Thermus thermophilus 70S (near-cognate); 23S rRNA 6nwy RB 120 3.5 RF00001 URS00005F2F4B_300852 33016876 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> ((((((((((.....((((((.(....(((.((....(.....)....))...)))...).)))).))(((.......((.(((((....))))).)).......)))..)))))))))) Modified tRNA(Pro) bound to Thermus thermophilus 70S (near-cognate); 5S rRNA 6nwy XA 1515 3.5 RF00177,RF01959,RF01960 URS000080DFED_300852 33016876 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucaccuccuuu ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<...<..<<<.<<<..<<<..<<..<<<<<<.<.......>.>>>>>>..>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>....<<<<.<<<<<....>>>>>.>>>>...<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>...>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<.<<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<...<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<......>>>>>>...<<<......>>>..>>>>>>>>.<<<.<<<..<<<<<........<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>..........>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>...........>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.............. ....((((..[.[[[..)))).((((.(((((..((((((.((....(((.(((..(((..((..(((.((((.......)))).)))..)))))......(((......((((((((..((....(((((..(((((....((((........)))).....)))))....((((.((.(.(...).))).))))...((.(...).))..)))))...))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(.(((....)))..))))).)..))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.((((((..(((((((((.......((((((.....)))))).....)))))))..)).))))))..(((((((((...(((((((.(...((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((..((((((.((..(((((..((((.(((((......((........))..........(((((((..(...(...(((....((..((....).).)).....((......))....)))...)).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...(...(((.....)))).....)))))))..(...((((....))))......)..)))).....).).)))...)).)))))....)))))))..[)).))).)))).(...((((((......(((..(((.((((....))))).))....)))......))))))............((((((........))))))........)..))))).....(.(((((......]...))))).)......))...)))))).))).))..(.(..((.(.((((.(((...((((((((((((...(.((((....(((....))).)))).)..))))))))))))...))).))))..).))...)..)..(((((.(((....))).)))))}............. Modified tRNA(Pro) bound to Thermus thermophilus 70S (near-cognate); 16S rRNA 6nwy XV 77 3.5 RF00005 URS00001DEEBE_562 33016876 0030533 0006412 562 cggugauuggcgcagccugguagcgcacuucguucggnacgaaggggucggagguucgaauccucuaucaccgacca <<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.........)))).((.(.........).))......((((.......)))).))))))).... Modified tRNA(Pro) bound to Thermus thermophilus 70S (near-cognate); E-site tRNA-Pro 6nwy XX 19 3.5 33016876 562 ggcaaggagguaaaacccu ................... ................... Modified tRNA(Pro) bound to Thermus thermophilus 70S (near-cognate); mRNA 6nwy YA 2883 3.5 RF02540,RF02541,RF00002 URS00001698E8_300852 33016876 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<..>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<..>...>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<..<...<<<<.......>>>>...>..........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>....<<.....>>......<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((..)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....(())...)))))))))))))..((.(...((((((.....((((((((((.(((....((((((......))))))....[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((.(((...(((...((((((((.(.((((((......)))).)))..))))))))..)).)...))).)))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......(((((..((..(.............)..))......(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))(.((((((.....)))))).)....))))))(((((((...(((.......((((.(((....)))))))....)))..))))).)).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....((((..(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((....)))).....))))))...)))...))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((.((.((((((....(.........(((((..(((......((((((((....))))))))...)))............))))))....)))))).)).)))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....((.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..))....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(..................(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Modified tRNA(Pro) bound to Thermus thermophilus 70S (near-cognate); 23S rRNA 6nwy YB 120 3.5 RF00001 URS00005F2F4B_300852 33016876 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> (((((((((((....((((((((....((((((....(.....)....)))..)))...)))))).))(((.......((.(((((....))))).)).......))).))))))))))) Modified tRNA(Pro) bound to Thermus thermophilus 70S (near-cognate); 5S rRNA 6o1o M 36 3.8 URS0000EEAD21_274 31278272 274 ugcgacccguagauaaggcgcccggggacgaccacg .................................... .................................... Cryo-EM structure of the T. thermophilus Csm complex bound to target ssRNA; RNA (36-MER) 6o1o N 30 3.8 URS0000EEACF6_274 31278272 274 ugacguggucguccccgggcgccuuaucua .............................. .............................. Cryo-EM structure of the T. thermophilus Csm complex bound to target ssRNA; RNA (30-MER) 6o3m QA 1500 3.97 RF00177,RF01959,RF01960 URS000080DFED_300852 33016876 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggggucuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<...>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>.....<......>....>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..((((((.((....(((.(((..(((..((.((((((((((.)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(.(((....)))..))))).)..))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((.(((((((......((((((.....))))))....)))))))...)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((.(((((...))))).))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((((..(((((((....))))))).....((....))....))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.((((((........(((.....))).......))))))......((((....)))).........)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((..........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Unmodified tRNA(Pro) bound to Thermus thermophilus 70S (cognate); 16S rRNA 6o3m QV 77 3.97 RF00005 URS00001DEEBE_562 33016876 0030533 0006412 562 cggugauuggcgcagccugguagcgcacuucguucgggacgaaggggucggagguucgaauccucuaucaccgacca <<<<<<...<<<<.........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>.>>>>>>.... (((((((..((((......[..)))).(((((.......)))))......((((..]....)))).))))))).... Unmodified tRNA(Pro) bound to Thermus thermophilus 70S (cognate); P-site ASLPro 6o3m QX 19 3.97 33016876 562 ggcaaggagguaaaaccgg ................... ................... Unmodified tRNA(Pro) bound to Thermus thermophilus 70S (cognate); mRNA 6o3m RA 2882 3.97 RF02540,RF02541,RF00002 URS00001698E8_300852 33016876 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu .<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<..>...>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<....<<<<<......>>>>.>....>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<.<<<...<.......<<<<<<<<....>>>>>>>>....>.............>>>.>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<<<<<<<<<..<<.......>>>..>>>>>>>..>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<<.....>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>. .((......((((((((((.....(((..((((((((((((......((((((.[[..[[[)))...].((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....(())...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((...(((((........))).))...)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((........((((..(...(((.........)))...)..........((......))...))))....)))))))))).))..........]]].)....))))))))))...)))))))(((((((.......)))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((.(((((((.((.....)))))))))......))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((((.((((.(.............(..(((......((((((((....))))))))...)))............)....).)))).)))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(..(((.....))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...))). Unmodified tRNA(Pro) bound to Thermus thermophilus 70S (cognate); 23S rRNA 6o3m RB 120 3.97 RF00001 URS00005F2F4B_300852 33016876 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).)))))))))). Unmodified tRNA(Pro) bound to Thermus thermophilus 70S (cognate); 5S rRNA 6o3m XA 1500 3.97 RF00177,RF01959,RF01960 URS000080DFED_300852 33016876 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggggacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<<<<<<<<...>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<......>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(.((.(((.(.).))).)).).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((.(.(..(((((((....)))))))...((.(.....)))..)..)))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((.......(((.....)))......))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Unmodified tRNA(Pro) bound to Thermus thermophilus 70S (cognate); 16S rRNA 6o3m XX 19 3.97 33016876 562 ggcaaggagguaaaaccgg ................... ................... Unmodified tRNA(Pro) bound to Thermus thermophilus 70S (cognate); mRNA 6o3m YA 2883 3.97 RF02540,RF02541,RF00002 URS00001698E8_300852 33016876 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<....<<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<..>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>.............>....>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<..>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<<..>>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<...<<......<<<<<<<<....>>>>>>>>...>>.............>>>>>..>>>>.>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<<<<<<<<...<<.......>>...>>>>>>>..>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<<.....>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((..)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....(())...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((...((..((......))...))...)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((........((((.(((...(...........)...))).....(...((......)).).))))....)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(....(((....)))......))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((.(((((.(.((((...........((..(...(.......((((((((....))))))))....).............)..))..))))..)))))).)))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...((.((((.(.(((((.........)))))...).((][.[[[))....)))).))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(..(((.....))).....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))...)))) Unmodified tRNA(Pro) bound to Thermus thermophilus 70S (cognate); 23S rRNA 6o3m YB 120 3.97 RF00001 URS00005F2F4B_300852 33016876 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).)))))))))). Unmodified tRNA(Pro) bound to Thermus thermophilus 70S (cognate); 5S rRNA 6o3m XV 77 3.97 RF00005 URS00001DEEBE_562 33016876 0030533 0006412 562 cggugauuggcgcagccugguagcgcacuucguucgggacgaaggggucggagguucgaauccucuaucaccgacca <<<<<<<..<<<<.........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((......[..)))).(((((.......)))))......((((..]....)))).))))))).... Unmodified tRNA(Pro) bound to Thermus thermophilus 70S (cognate); P-site ASLPro 6o5f C 23 2.504 URS000080DD89_32630 31300642 32630 caaggucauucgcaagaguggcc ....................... ....................... Crystal structure of DEAD-box RNA helicase DDX3X at pre-unwound state; RNA (5'-R(P*CP*AP*AP*GP*GP*UP*CP*AP*UP*UP*CP*GP*CP*AP*AP*GP*AP*GP*UP*GP*GP*CP*C)-3') 6o5f D 24 2.504 URS000080DD89_32630 31300642 32630 ggucauucgcaagaguggccuugc ........................ ........................ Crystal structure of DEAD-box RNA helicase DDX3X at pre-unwound state; RNA (5'-R(P*CP*AP*AP*GP*GP*UP*CP*AP*UP*UP*CP*GP*CP*AP*AP*GP*AP*GP*UP*GP*GP*CP*C)-3') 6o7e G 27 3.2 URS0000E60B95_342948 31326272 342948 guggaaaggcgggcagaggcgguuugc ........................... ........................... Cryo-EM structure of Csm-crRNA-target RNA ternary complex in complex with AMPPNP in type III-A CRISPR-Cas system; RNA (38-MER) 6o7e H 19 3.2 URS0000E60BAF_342948 31326272 342948 gcaaaccgccucugcccgc ................... ................... Cryo-EM structure of Csm-crRNA-target RNA ternary complex in complex with AMPPNP in type III-A CRISPR-Cas system; RNA (40-MER) 6o7h G 27 2.9 URS0000E60B95_523850 31326272 523850 guggaaaggcgggcagaggcgguuugc ........................... ........................... Cryo-EM structure of Csm-crRNA-target RNA ternary complex in complex with cA4 in type III-A CRISPR-Cas system; RNA (38-MER) 6o7h H 19 2.9 URS0000E60BAF_523850 31326272 523850 gcaaaccgccucugcccgc ................... ................... Cryo-EM structure of Csm-crRNA-target RNA ternary complex in complex with cA4 in type III-A CRISPR-Cas system; RNA (40-MER) 6o7i G 26 3.2 URS0000E60B95_342948 31326272 342948 guggaaaggcgggcagaggcgguuug .......................... .......................... Cryo-EM structure of Csm-crRNA-target RNA ternary bigger complex in complex with cA4 in type III-A CRISPR-Cas system; RNA (38-MER) 6o7i H 19 3.2 URS0000E60BAF_342948 31326272 342948 caaaccgccucugcccgcg ................... ................... Cryo-EM structure of Csm-crRNA-target RNA ternary bigger complex in complex with cA4 in type III-A CRISPR-Cas system; RNA (40-MER) 6o7k g 1539 4.2 RF00177,RF01959,RF01960 URS000080DDC0_562 31108498 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<<....>>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<...<<....>>.>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<.<<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>..>>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((((....))))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((((.......)))))))).....)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))...((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((....(..(((.....)))).....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... 30S initiation complex; 16S ribosomal RNA 6o7k v 77 4.2 RF00005 URS00001BBAFC_562 31108498 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaagaucgucgguucaaauccggcccccgcaacca ..<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>...... ...((((..((((.........)))).(((((.......))))).....(((((.......)))))))))....... 30S initiation complex; tRNA 6o8w a 1523 3.53 RF00177,RF01959,RF01960 URS00021ED8EB_1351 33004869 0003735 0005840 1351 ugagaguuugauccuggcucaggacgaacgcuggcggcgugccuaauacaugcaagucgaacgcuucuuggaaagaggaguggcggacgggugaguaacacguggguaaccuacccaucagagggggauaacacuuggaaacaggugcuaauaccgcauaacaguuuaugccgcauggcauaagagugaaaggcgcuuucgggugucgcugauggauggacccgcggugcauuagcuaguuggugagguaacggcucaccaaggccacgaugcauagccgaccugagagggugaucggccacacugggacugagacacggcccagacuccuacgggaggcagcaguagggaaucuucggcaauggacgaaagucugaccgagcaacgccgcgugagugaagaagguuuucggaucguaaaacucuguuguuagagaagaacaaggacguuaguaacugaacguccccugacgguaucuaaccagaaagccacggcuaacuacgugccagcagccgcgguaauacguagguggcaagcguuguccggauuuauugggcguaaagcgagcgcaggcgguuucuuaagucugaugugaaagcccccggcucaaccggggagggucauuggaaacugggagacuugagugcagaagaggagaguggaauuccauguguagcggugaaaugcguagauauauggaggaacaccaguggcgaaggcggcucucuggucuguaacugacgcugaggcucgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugagugcuaaguguuggaggguuuccgcccuucagugcugcagcaaacgcauuaagcacuccgccuggggaguacgaccgcaagguugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggucuugacauccuuugaccacucuagagauagagcuuucccuucggggacaaagugacagguggugcaugguugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuuauuguuaguugccaucauuuaguugggcacucuagcgagacugccggugacaaaccggaggaagguggggaugacgucaaaucaucaugccccuuaugaccugggcuacacacgugcuacaaugggaaguacaacgagucgcuagaccgcgaggucaugcaaaucucuuaaagcuucucucaguucggauugcaggcugcaacucgccugcaugaagccggaaucgcuaguaaucgcggaucagcacgccgcggugaauacguucccgggccuuguacacaccgcccgucacaccacgagaguuuguaacacccgaagucggugagguaaccuuuuuggagccagccgccuaaggugggauagaugauuggggugaagucguaacaagguagccguaucggaaggugcggcuggauca ...<<<<....((((.>>>>.<<<..........<.<<<<<.....<<<.<<<..<<<..<<.<<<<<.....>>>>>.>>>>>......<<........<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<<....>>>>>>......>>.>.....<.<<<<<<<<....>>>>>>>>..>....<<<<<......>>>>>.>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<........>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.......<.<<<....<<<<....>>>>..>>>>.>>.>>>.>...<<<<......<<<<....>>>>.....>>>>...<<<<<<<.........<<.<<............>>..>>.........>>>>>>...>..<<<<<(((...<<<<<.....<..))).>.......>>>>>>>>>>........>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<.......<<<<<<.....>>>>>>.....>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<<..<<<......>>>.....>>>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<......>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..))))..<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<.......<<<<<.....<<<<<....>>>>>................>>>>.>..<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<...<.....>..>>>...>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<..<<<<...<<.<<<<..<<<..<<.....>>.>>>.>>>>.>>..>>>>..>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ...((((..[.[[[..)))).((..........((.((((((....(((.(((..(.(..((.((((((...)))))).))).)......(((.......(((((((..((...(((((((.(.((.....(((.((....)).)))......)).).......((((((((....)))))))).......(.(.(......).).).)))))))..))))))))).(((....(((..((((((((.......)))))))))))......)))..((((((.(.....)))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(.(((....)))..))))).)).))).))..((((......((((....)))).....))))....((((((.........((....(.........)....)).........))))))........((([[[...(((((.....((.]]])).......))))))).)..........))..........((([....(.((((...(((.(((((((.((((((((((.......(((((.....)))))....).)))))))..)))))))))..(((..((((...((((((((....(((((.(...((........))......).)))))....).......((....)).)))))))..))))...))..))))...))))....((((((...((...((((.........))))...))))))))..........((((((..(((..(((((((......)))))))..)))...((...])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((......(((.(....).)))......((....))...))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(........))))...)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(.((((......(((..((..((((....))))..))....)))......)))).)......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((..((((....(.((((..((...((.....))..)).)))).)...))))..))))))..))).))))..).))...)..)..(((((((((....)))))))))...... Cryo-EM image reconstruction of the 70S Ribosome Enterococcus faecalis Class01; 16S rRNA 6o8w u 76 3.53 RF00005 URS00005AA258_1351 33004869 0030533 0006412 1351 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((........)))).((((.........)))).....((.((.......)).))))))))).... Cryo-EM image reconstruction of the 70S Ribosome Enterococcus faecalis Class01; tRNA 6o8w A 2903 3.53 RF02540,RF02541,RF00002 URS00021ED8EF_1351 33004869 0003735 0005840 1351 uuaagugaauaagggcgcacgguggaugccuuggcacuaggagccgaugaaggacgggacuaacaccgauaugcuuuggggagcuguaaguaagcuaugauccagagauuuccgaaugggggaacccaauaucuuuuauaggauauuacuuuucagugaauacauagcugauuagagguagacgcagagaacugaaacaucuuaguaccugcaggaagagaaagaaaauucgauucccugaguagcggcgagcgaaacgggaagagcccaaaccaacaagcuugcuuguugggguuguaggacuccgauaugguagucuguuaguauaguugaaggauuuggaaaauuccgcuaaagagggugaaagccccguagacgaaaugcugacaacaccuaggaggauccugaguacggcggaacacgagaaauuccgucggaauccgcggggaccaucccgcaaggcuaaauacucccuagugaccgauagugaaccaguaccgugagggaaaggugaaaagcaccccggaaggggagugaaauagauccugaaaccgugugccuacaacaagucaaagcucguuaaugagugauggcgugccuuuuguagaaugaaccggcgaguuacgauugcaugcgagguuaagucgaagagacggagccgcagcgaaagcgagucugaauagggcgaaugaguauguagucguagacccgaaaccaugugaucuacccauguccagguugaaggugcgguaaaacgcacuggaggaccgaacccacguacguugaaaagugcggggaugagguguggguagcggagaaauuccaaacgaacuuggagauagcugguucucuccgaaauagcuuuagggcuagccucggaauugagaaugauggagguagagcacuguuuggacuaggggcccaucggguuaccgaauucagauaaacuccgaaugccauucauuuauauccgggagucagacugcgagugauaagauccguagucgaaagggaaacagcccagaccaccagcuaaggucccaaaauauauguuaaguggaaaaggaugugggguugcacagacaacuaggauguuggcuuagaagcagccaccauuuaaagagugcguaauagcucacuagucgagugacccugcgccgaaaauguaccggggcuaaacauauuaccgaagcuguggacuacaccauuagguguagugguaggagagcguucuaagggcguugaaggucgaucgugaggacggcuggagcgcuuagaagugagaaugccgguaugaguagcgaaagacaggugagaauccuguccaccguaugacuaagguuuccuggggaaggcucguccgcccaggguuagucgggaccuaagccgaggccgauaggcguaggcgauggacaacagguugauauuccuguaccaguuguuuuuguuugagcaauggagggacgcaguaggcuaaggaaugcaugcgauuggaagugcauguccaagcaaugagucuugaguagaguuaaaugcuuuacucuuuaaggacaaguugugacggggagcgaaauaguagcgaaguuccugacgucacacugccaagaaaagcuucuagugagaaaacaacugcccguaccguaaaccgacacagguagucgaggagaguauccuaaggugagcgagcgaacucucguuaaggaacucggcaaaaugaccccguaacuucgggagaaggggugcugacuucggucagccgcagugaauaggcccaagcgacuguuuaucaaaaacacaggucucugcaaaaucguaagaugaaguauaggggcugacgccugcccggugcuggaagguuaagaggauggguuagcuucggcgaagcucagaauugaagccccaguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgacccgcacgaaaggcguaacgauuugggcacugucucaacgagagacucggugaaauuuuaguaccugugaagaugcagguuacccgcgacaggacggaaagaccccauggagcuuuacuguaguuugauauugaguguuuguaccacauguacaggauagguaggagccgaugagaccggaacgcuaguuucggaggaggcgcuggugggauacuacccuuguguuaugaacccucuaacccgcaccacuaaucguggugggagacagugucagaugggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguucccucagaaugguuggaaaucauucgaagaguguaaaggcagaagggagcuugacugcgagaccuacaagucgagcagggacgaaagucgggcuuagugauccggugguuccgcauggaagggccaucgcucaacggauaaaagcuacccuggggauaacaggcuuaucucccccaagaguccacaucgacggggagguuuggcaccucgaugucggcucgucgcauccuggggcuguagucggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucccuauccgucgcgggcguuggaaauuugagaggagcuguccuuaguacgagaggaccgggauggacuuaccgcugguguaccaguuguucugccaagggcauugcuggguagcuauguagggaagggauaaacgcugaaagcaucuaagugugaagcccaccucaagaugagauuucccauuucuuuaagaaaguaagaccccugagagaugaucagguagauagguuggaaguggaaggcuagugauaguuggagcggaccaauacuaaucggucgaggacuuaac <<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<..<<<<<.........>>>>>..>>.>>....<<<<<......<......>.......>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..(((....<<<<<<<<....>>>>>>>>......<<<<<<<<...<.<<<.<<.<<<<<<<<<.<<<...<<<.<......>.>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>>.>>>>..>>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<......>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>......>>>>>>>>>>>>>..<<.<..<<<<.<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>.>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<..<..<<<<<<<<............<<.<<<<....<<...<.....>....>>....>>>>.>>............>>>.>>>>>..>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<.<<..<<..<<<.........>>>..>>.......................>>.>>....>>>>>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<......>>>>>>>....>>>>>>..<<<<<<<.<<......<<<<<.<<....>>.>>>>>...>>.>>>>>>>........>>>>>><......<<....<<<<<<.......>>>>>><<<<....<<<<<.<<<..<<<<<<...<<.....>>.>>>>>>....((<<<<.<<.<.<<<...<<<....>>>...>>>..>>>...<<<<<........>>>>>))<<<<<<<..........<<...<<<<....<<<<..<<...<<<<<...........{...........<...<<<<<..<<<<.<<<<<<<<<.....>>>>>>>>>.....>>>>..>>>>>....>...<<.........>>....>>>>>....>>...>>>>.........>>>>..>>......>>>>>>>>>>>.>>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<....>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<..<<...<<<<<<.<<....>>..>>>>>>...>>..>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<<.<<<.<<<<<<<.<<<<...........<<<<<............<<<<<<<....>>>>>>>...................>>>>>..>>>>.>>>>>>>.>>>....<<.<<<<<<.....>>>>>>>>.....>>>>>>>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.}..>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<......>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>...>>>>....>>>>>>. ((((((......((((((((((.....(((..(((((((((((((......((((((.[[..[[[)))...].((((((...(((]]..]].)))......))))))...)))....(((....)))(((((((......))))))).((..(((((.........)))))..)).))....(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((((((......)))))))....{.((((((((.....(((.((.(((((((((.(((...(((.(......).)))[[(...).(((.....]])))...)))...))))))))))))))..))))..)))))....(((((((...[.......)))))))....}.(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((..((((..[...))))..)))).<.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))...(((.....))).......)))))))))))))...(((...(((.((.....((((((.(((.((((...((((((......))))))...).)))...(((.(((((........))))))))..).)).)))))).(.(((....[)))...).])).)))......).))..((((((....(((((....)))))((((((((....((((((((.(............((.((((....(...((...)).....)...)))).)).............))).))))).).)))))).))..((((..(.((......)).)..))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.((.(...((..(((.........)))..))........................).))...)))))))))).))...........]]].)...))))))))))...)))))))((((((........))))))....))))))(.(((((((.((......(((((.((....))])))))...)).)))))))..).....))))))(......((....((((((.......))))))((((....(((...((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]]((((((.......(.)..(...((((....((((..(((..(((((..(..((....{.....))..)..(..(((((..((((.(((((..((.....))..))))).....))))..)))))...)....((.........))....)))))...)))...))))(..).....))))..)........)))))))))).))).....((......))..))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.[..).....)))))((((((....))))))(...).......(((((((((...((.........))...(((((((.....(((....))).......))))))).].(((.(((..(((((((..(((...((...(((((..((....))...)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).)))))).....)).[..(((((.....>].)))))..((((((((.(((.((......((((.((((((..(((((.(((((((((.(((.(((.(((.((((.(.........(((((..(.(........((((((....))))).).....))............)))))).)))).))).))).)))....((.((((((.....)))))))).....)))))))))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}..))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..((..(..)..))..(..(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))..).)))))). Cryo-EM image reconstruction of the 70S Ribosome Enterococcus faecalis Class01; 50S subunit 6o8w B 116 3.53 RF00001 URS0000240630_1351 33004869 0003735 0005840 1351 ugugguggcgauagcgagaaggauacaccuguucccaugccgaacacagaaguuaagcuucuuagcgccgauuguagugaaggguuucccuuugugagaguaggacgucgccacgc <<<<<<<<<....<<<<<<<<.....<<<<<<.............>>>>..>>....>>>>>>.>>.<<.....<.<<<<<<<<...>>>>>>>>...>...>>..>>>>>>>>>. (((((((((....((.(((((.....((((((...(.....)...))))..))....)))))..))..(...........(((.....)))...........)...))))))))). Cryo-EM image reconstruction of the 70S Ribosome Enterococcus faecalis Class01; 5S rRNA 6o8x a 1528 3.68 RF00177,RF01959,RF01960 URS00021ED954_1351 33004869 0003735 0005840 1351 ugagaguuugauccuggcucaggacgaacgcuggcggcgugccuaauacaugcaagucgaacgcuucuuuccuuggaaagaggaguggcggacgggugaguaacacguggguaaccuacccaucagagggggauaacacuuggaaacaggugcuaauaccgcauaacaguuuaugccgcauggcauaagagugaaaggcgcuuucgggugucgcugauggauggacccgcggugcauuagcuaguuggugagguaacggcucaccaaggccacgaugcauagccgaccugagagggugaucggccacacugggacugagacacggcccagacuccuacgggaggcagcaguagggaaucuucggcaauggacgaaagucugaccgagcaacgccgcgugagugaagaagguuuucggaucguaaaacucuguuguuagagaagaacaaggacguuaguaacugaacguccccugacgguaucuaaccagaaagccacggcuaacuacgugccagcagccgcgguaauacguagguggcaagcguuguccggauuuauugggcguaaagcgagcgcaggcgguuucuuaagucugaugugaaagcccccggcucaaccggggagggucauuggaaacugggagacuugagugcagaagaggagaguggaauuccauguguagcggugaaaugcguagauauauggaggaacaccaguggcgaaggcggcucucuggucuguaacugacgcugaggcucgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugagugcuaaguguuggaggguuuccgcccuucagugcugcagcaaacgcauuaagcacuccgccuggggaguacgaccgcaagguugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggucuugacauccuuugaccacucuagagauagagcuuucccuucggggacaaagugacagguggugcaugguugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuuauuguuaguugccaucauuuaguugggcacucuagcgagacugccggugacaaaccggaggaagguggggaugacgucaaaucaucaugccccuuaugaccugggcuacacacgugcuacaaugggaaguacaacgagucgcuagaccgcgaggucaugcaaaucucuuaaagcuucucucaguucggauugcaggcugcaacucgccugcaugaagccggaaucgcuaguaaucgcggaucagcacgccgcggugaauacguucccgggccuuguacacaccgcccgucacaccacgagaguuuguaacacccgaagucggugagguaaccuuuuuggagccagccgccuaaggugggauagaugauuggggugaagucguaacaagguagccguaucggaaggugcggcuggauca ...<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<<<<<<......>>>>>>>.>>>>>......<<........<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<<....>>>>>>......>>.>.......<<<<<<<<<..>>>>>>>>>.......<<<<........>>>>.>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>......<..<<<....<<<<....>>>>..>>>.>>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<<<<<<<.........<<.<<<..........>>>..>>.........>>>>>>...>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<.......<<<<<<.....>>>>>>.....>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<<..<<<......>>>.....>>>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<......>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<....<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<.......<<<.......<<<<<....>>>>>.......<...>.....>.>.>...<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<...<......>.>>>...>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>....>>>>>>>...>>.>>>>>>>>......<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>.......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>....>>.......<<.<.<<<<.<<<..<<<<<<..<<<<...<<.<<<<..<<<..<<.....>>.>>>.>>>>.>>..>>>>..>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>...... ...((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((........)))))).)))))......(((.......(((((((..((...(((((((.(.((.....((((((....))))))......)).)........(((((((....)))))))........(.(((......))).).)))))))..))))))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....((((((..........(....(.........)....)..........))))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((....((.(((((((.((((((((((......((((((.....))))))...).)))))))..)))))))))..(((..((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))))...))..)))....))))....((((((...((...((((.........))))...))))))))..........((((((..((((((((((((......))))))))))))...((..]])).....)))))))))).(.(......((((....))))....).)...]]].](((....((((((.((..(((.(..((((((((((......((........))..........(((((((..(...(((........(((((....)))))......(.....)......).))).((.((....((.(((.(....((((((.((....))....((........))...)))))).....(((..(.(.(((..(((..((......)))))...))).).)..(..(((((.....))))).....)...))).....).).))....))..))))....)))))))...)).)))))))).(...((((((......(((..((..((((....))))..))....)))......))))))......(..(.(((((((........))))))))...)..)..).))).....(((((((.........)))))))......))...))))))...).)).......((.(.((((.(((..((((((..((((....(.((((..(((..((.....)).))).)))).)...))))..))))))..))).))))..).)).........(((((((((....)))))))))...... Cryo-EM image reconstruction of the 70S Ribosome Enterococcus faecalis Class02; 16S rRNA 6o8x A 2898 3.68 RF02540,RF02541,RF00002 URS00021ED8EF_1351 33004869 0003735 0005840 1351 uuaagugaauaagggcgcacgguggaugccuuggcacuaggagccgaugaaggacgggacuaacaccgauaugcuuuggggagcuguaaguaagcuaugauccagagauuuccgaaugggggaacccaauaucuuuuauaggauauuacuuuucagugaauacauagcugauuagagguagacgcagagaacugaaacaucuuaguaccugcaggaagagaaagaaaauucgauucccugaguagcggcgagcgaaacgggaagagcccaaaccaacaagcuugcuuguugggguuguaggacuccgauaugguagucuguuaguauaguugaaggauuuggaaaauuccgcuaaagagggugaaagccccguagacgaaaugcugacaacaccuaggaggauccugaguacggcggaacacgagaaauuccgucggaauccgcggggaccaucccgcaaggcuaaauacucccuagugaccgauagugaaccaguaccgugagggaaaggugaaaagcaccccggaaggggagugaaauagauccugaaaccgugugccuacaacaagucaaagcucguuaaugagugauggcgugccuuuuguagaaugaaccggcgaguuacgauugcaugcgagguuaagucgaagagacggagccgcagcgaaagcgagucugaauagggcgaaugaguauguagucguagacccgaaaccaugugaucuacccauguccagguugaaggugcgguaaaacgcacuggaggaccgaacccacguacguugaaaagugcggggaugagguguggguagcggagaaauuccaaacgaacuuggagauagcugguucucuccgaaauagcuuuagggcuagccucggaauugagaaugauggagguagagcacuguuuggacuaggggcccaucggguuaccgaauucagauaaacuccgaaugccauucauuuauauccgggagucagacugcgagugauaagauccguagucgaaagggaaacagcccagaccaccagcuaaggucccaaaauauauguuaaguggaaaaggaugugggguugcacagacaacuaggauguuggcuuagaagcagccaccauuuaaagagugcguaauagcucacuagucgagugacccugcgccgaaaauguaccggggcuaaacauauuaccgaagcuguggacuacaccauuagguguagugguaggagagcguucuaagggcguugaaggucgaucgugaggacggcuggagcgcuuagaagugagaaugccgguaugaguagcgaaagacaggugagaauccuguccaccguaugacuaagguuuccuggggaaggcucguccgcccaggguuagucgggaccuaagccgaggccgauaggcguaggcgauggacaacagguugauauuccuguaccaguuguuuuuguuugagcaauggagggacgcaguaggcuaaggaaugcaugcgauuggaagugcauguccaagcaaugagucuugaguagaguuaaaugcuuuacucuuuaaggacaaguugugacggggagcgaaauaguagcgaaguuccugacgucacacugccaagaaaagcuucuagugagaaaacaacugcccguaccguaaaccgacacagguagucgaggagaguauccuaaggugagcgagcgaacucucguuaaggaacucggcaaaaugaccccguaacuucgggagaaggggugcugacuucggucagccgcagugaauaggcccaagcgacuguuuaucaaaaacacaggucucugcaaaaucguaagaugaaguauaggggcugacgccugcccggugcuggaagguuaagaggauggguuagcuucggcgaagcucagaauugaagccccaguaaacggcggccguuaacgguccuaagguagcgaaauuccuugucggguaaguuccgacccgcacgaaaggcguaacgauuugggcacugucucaacgagagacucggugaaauuuuaguaccugugaagaugcagguuacccgcgacaggacggaaagaccccauggagcuuuacuguaguuugauauugaguguuuguaccacauguacaggauagguaggagccgaugagaccggaacgcuaguuucggaggaggcgcuggugggauacuacccuuguguuaugaacccucuaacccgcaccacuaaucguggugggagacagugucagaugggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguucccucagaaugguuggaaaucauucgaagaguguaaaggcagaagggagcuugacugcgagaccuacaagucgagcagggacgaaagucgggcuuagugauccggugguuccgcauggaagggccaucgcucaacggauaaaagcuacccuggggauaacaggcuuaucucccccaagaguccacaucgacggggagguuuggcaccucgaugucggcucgucgcauccuggggcuguagucggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucccuauccgucgcgggcguuggaaauuugagaggagcuguccuuaguacgagaggaccgggauggacuuaccgcugguguaccaguuguucugccaagggcauugcuggguagcuauguagggaagggauaaacgcugaaagcaucuaagugugaagcccaccucaagaugagauuucccauuucuuuaagaaaguaagaccccugagagaugaucagguagauagguuggaaguggaaggcuagugauaguuggagcggaccaauacuaaucggucgaggacuuaac 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Cryo-EM image reconstruction of the 70S Ribosome Enterococcus faecalis Class02; 23S rRNA 6o8x B 116 3.68 RF00001 URS0000240630_1351 33004869 0003735 0005840 1351 ugugguggcgauagcgagaaggauacaccuguucccaugccgaacacagaaguuaagcuucuuagcgccgauuguagugaaggguuucccuuugugagaguaggacgucgccacgc <<<<<<<<.....<<<<<<<<.....<<<<<<.............>>>>..>>....>>>>>>.>>.<<...<...<<<<<<<<...>>>>>>>>....>..>>...>>>>>>>>. .((((((((....((.(((((.....((.(((...(.....)...)))...))....)))))..))..(.......(((((((.....))))))).......)...)))))))).. Cryo-EM image reconstruction of the 70S Ribosome Enterococcus faecalis Class02; 5S rRNA 6o8y a 1528 4.14 RF00177,RF01959,RF01960 URS00021ED954_1351 33004869 0003735 0005840 1351 ugagaguuugauccuggcucaggacgaacgcuggcggcgugccuaauacaugcaagucgaacgcuucuuuccuuggaaagaggaguggcggacgggugaguaacacguggguaaccuacccaucagagggggauaacacuuggaaacaggugcuaauaccgcauaacaguuuaugccgcauggcauaagagugaaaggcgcuuucgggugucgcugauggauggacccgcggugcauuagcuaguuggugagguaacggcucaccaaggccacgaugcauagccgaccugagagggugaucggccacacugggacugagacacggcccagacuccuacgggaggcagcaguagggaaucuucggcaauggacgaaagucugaccgagcaacgccgcgugagugaagaagguuuucggaucguaaaacucuguuguuagagaagaacaaggacguuaguaacugaacguccccugacgguaucuaaccagaaagccacggcuaacuacgugccagcagccgcgguaauacguagguggcaagcguuguccggauuuauugggcguaaagcgagcgcaggcgguuucuuaagucugaugugaaagcccccggcucaaccggggagggucauuggaaacugggagacuugagugcagaagaggagaguggaauuccauguguagcggugaaaugcguagauauauggaggaacaccaguggcgaaggcggcucucuggucuguaacugacgcugaggcucgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugagugcuaaguguuggaggguuuccgcccuucagugcugcagcaaacgcauuaagcacuccgccuggggaguacgaccgcaagguugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggucuugacauccuuugaccacucuagagauagagcuuucccuucggggacaaagugacagguggugcaugguugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuuauuguuaguugccaucauuuaguugggcacucuagcgagacugccggugacaaaccggaggaagguggggaugacgucaaaucaucaugccccuuaugaccugggcuacacacgugcuacaaugggaaguacaacgagucgcuagaccgcgaggucaugcaaaucucuuaaagcuucucucaguucggauugcaggcugcaacucgccugcaugaagccggaaucgcuaguaaucgcggaucagcacgccgcggugaauacguucccgggccuuguacacaccgcccgucacaccacgagaguuuguaacacccgaagucggugagguaaccuuuuuggagccagccgccuaaggugggauagaugauuggggugaagucguaacaagguagccguaucggaaggugcggcuggauca ...<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<<<<<<......>>>>>>>.>>>>>......<<........<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<<....>>>>>>......>>.>.......<<<<<<<<....>>>>>>>>.......<<<<<<....>>>>>>.>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<<.........<<.<..............>..>>.........>>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<.......<<<<<<.....>>>>>>.....>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<<..<<<......>>>.....>>>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<......>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<...<<<<<<<<<<......<<........>>..........<<<<<<<.................<<<<<....>>>>>.........................<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<..<<<<<<<..<<<..<<......>>>>>...>>>>>>>.....<<<<<.....>>>>>.........>>>.........>>>...>>>>>>>>....>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<....<<....>>....>>....>>>.....>>>>>>>.........<<.<<<<<<........>>>>>>>>..........>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>.......<<...<<<<.<<<..<<<<<<..<<<<...<<.<<<<..<<<..<<.....>>.>>>.>>>>.>>..>>>>..>>>>>>..>>>.>>>>....>>.........<<<<<<<<<....>>>>>>>>>...... ...(((...[.[[[...))).((((.(((((..(((((((((....(((.(((..(((..((.((((((........)))))).)))))......(((.......(((((((..((...(((((((.(.((.....(((.((....)).)))......)).)........(((((((....)))))))........(.(((......))).).)))))))..))))))))).(((....((...((((((((.......)))))))).))......)))..((((((((....))))...))))))).(((((.(.........)))))).((((....))))...)))))).).....(.(((...(.(((....)))..))))).)).))))))..((((......((((....)))).....))))....((((((..........(....(.........)....)..........))))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.((.((((.(((((((((.......((((((.....)))))).....)))))))..)))))).))..((...((((...((((((((....(((((.(...((........))......).)))))....).......((....)).)))))))..))))....)..))))...))))....((((((...((...((((.........))))...))))))))..........((((((..(((((((.((((......)))).)))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].]((((...((((((.((..(((....((((.(((((......((........))..........(((((((..(....(.........(((((....)))))......(.....)........).).((.(((....(((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((.(((..(((..(........))))...))).)))..(..(((((.....))))).....)..)))).....).).)))...)..)))))....)))))))...)).))).)))).(...(((((((.....(((..((..(.((....)).)..))....))).....)))))))......(....(((((((........)))))))....)..)....))).....(.(((((.........))))).)......))...)))).)).)).))..(....((...((((.(((..((((((..((((....(.((((..(((..((.....)).))).)))).)...))))..))))))..))).))))....))......)..(((((((((....)))))))))...... Cryo-EM image reconstruction of the 70S Ribosome Enterococcus faecalis Class03; 16S rRNA 6o8y A 2897 4.14 RF02540,RF02541,RF00002 URS00021ED8EF_1351 33004869 0003735 0005840 1351 uuaagugaauaagggcgcacgguggaugccuuggcacuaggagccgaugaaggacgggacuaacaccgauaugcuuuggggagcuguaaguaagcuaugauccagagauuuccgaaugggggaacccaauaucuuuuauaggauauuacuuuucagugaauacauagcugauuagagguagacgcagagaacugaaacaucuuaguaccugcaggaagagaaagaaaauucgauucccugaguagcggcgagcgaaacgggaagagcccaaaccaacaagcuugcuuguugggguuguaggacuccgauaugguagucuguuaguauaguugaaggauuuggaaaauuccgcuaaagagggugaaagccccguagacgaaaugcugacaacaccuaggaggauccugaguacggcggaacacgagaaauuccgucggaauccgcggggaccaucccgcaaggcuaaauacucccuagugaccgauagugaaccaguaccgugagggaaaggugaaaagcaccccggaaggggagugaaauagauccugaaaccgugugccuacaacaagucaaagcucguuaaugagugauggcgugccuuuuguagaaugaaccggcgaguuacgauugcaugcgagguuaagucgaagagacggagccgcagcgaaagcgagucugaauagggcgaaugaguauguagucguagacccgaaaccaugugaucuacccauguccagguugaaggugcgguaaaacgcacuggaggaccgaacccacguacguugaaaagugcggggaugagguguggguagcggagaaauuccaaacgaacuuggagauagcugguucucuccgaaauagcuuuagggcuagccucggaauugagaaugauggagguagagcacuguuuggacuaggggcccaucggguuaccgaauucagauaaacuccgaaugccauucauuuauauccgggagucagacugcgagugauaagauccguagucgaaagggaaacagcccagaccaccagcuaaggucccaaaauauauguuaaguggaaaaggaugugggguugcacagacaacuaggauguuggcuuagaagcagccaccauuuaaagagugcguaauagcucacuagucgagugacccugcgccgaaaauguaccggggcuaaacauauuaccgaagcuguggacuacaccauuagguguagugguaggagagcguucuaagggcguugaaggucgaucgugaggacggcuggagcgcuuagaagugagaaugccgguaugaguagcgaaagacaggugagaauccuguccaccguaugacuaagguuuccuggggaaggcucguccgcccaggguuagucgggaccuaagccgaggccgauaggcguaggcgauggacaacagguugauauuccuguaccaguuguuuuuguuugagcaauggagggacgcaguaggcuaaggaaugcaugcgauuggaagugcauguccaagcaaugagucuugaguagaguuaaaugcuuuacucuuuaaggacaaguugugacggggagcgaaauaguagcgaaguuccugacgucacacugccaagaaaagcuucuagugagaaaacaacugcccguaccguaaaccgacacagguagucgaggagaguauccuaaggugagcgagcgaacucucguuaaggaacucggcaaaaugaccccguaacuucgggagaaggggugcugacuucggucagccgcagugaauaggcccaagcgacuguuuaucaaaaacacaggucucugcaaaaucguaagaugaaguauaggggcugacgccugcccggugcuggaagguuaagaggauggguuagcuucggcgaagcucagaauugaagccccaguaaacggcggccguaacgguccuaagguagcgaaauuccuugucggguaaguuccgacccgcacgaaaggcguaacgauuugggcacugucucaacgagagacucggugaaauuuuaguaccugugaagaugcagguuacccgcgacaggacggaaagaccccauggagcuuuacuguaguuugauauugaguguuuguaccacauguacaggauagguaggagccgaugagaccggaacgcuaguuucggaggaggcgcuggugggauacuacccuuguguuaugaacccucuaacccgcaccacuaaucguggugggagacagugucagaugggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguucccucagaaugguuggaaaucauucgaagaguguaaaggcagaagggagcuugacugcgagaccuacaagucgagcagggacgaaagucgggcuuagugauccggugguuccgcauggaagggccaucgcucaacggauaaaagcuacccuggggauaacaggcuuaucucccccaagaguccacaucgacggggagguuuggcaccucgaugucggcucgucgcauccuggggcuguagucggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucccuauccgucgcgggcguuggaaauuugagaggagcuguccuuaguacgagaggaccgggauggacuuaccgcugguguaccaguuguucugccaagggcauugcuggguagcuauguagggaagggauaaacgcugaaagcaucuaagugugaagcccaccucaagaugagauuucccauuucuuuaagaaaguaagaccccugagagaugaucagguagauagguuggaaguggaaggcuagugauaguuggagcggaccaauacuaaucggucgaggacuuaac <<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<..<<<<<.........>>>>>..>>.>>....<<<<<......<......>.......>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..(((....<<<<<<<......>>>>>>>......<<<<<<<<.....<<<.<<.<<<<<<<<<.<<<...<<<.<......>.>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>..>>>>..>>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<......>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.......>>...>>>...<<....>>...<<<.....>>>.......>>>>>>>>>>>>>..<<.<...<<<.<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>.>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<..<..<<<<<<<<<...........<<<<<<<<.......<<<...>>>........>>>>>>>>...........>>>>.>>>>>..>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<.....<...<.............>...>..........................>>....>>>>>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<....>>>>>>>>....>>>>>><.<<<<<<<.<<......<<<<<.<<....>>.>>>>>...>>.>>>>>>>..>.....>>>>>><......<<....<<<<<<.......>>>>>><<<<....<<<<<.<<<..<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<..........<<...<<<<....<<<<...<...<<<<<.........[.[...........<...<<<<<..<<<<.<<<<<<<<<.....>>>>>>>>>.....>>>>..>>>>>....>...<<.........>>....>>>>>....>....>>>>.........>>>>..>>......>>>>>>>>>>>.>>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<....>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<..<<....>>...>>>>>...>>...>>>>>>>>..>>>>><<<<<...>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.((......<<<<.((<<<<..<<<<<.<<<<<<<<<.<<<.<<<<<<<.<<<<...........<<<<<..<<<.......<<<<<<<....>>>>>>>....>>>............>>>>>..>>>>.>>>>>>>.>>>....<<.<<<<<<.....>>>>>>>>.....>>>>>>>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.((.((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))))......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..))>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<.<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>..>....<<<<<<<....>>>.>>>>....))..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.].]>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<......>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>...>>>>....>>>>>>. 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Cryo-EM image reconstruction of the 70S Ribosome Enterococcus faecalis Class03; 23S rRNA 6o8y B 116 4.14 RF00001 URS0000240630_1351 33004869 0003735 0005840 1351 ugugguggcgauagcgagaaggauacaccuguucccaugccgaacacagaaguuaagcuucuuagcgccgauuguagugaaggguuucccuuugugagaguaggacgucgccacgc <<<<<<<<.....<<<<<<<<.....<<<<<<.............>>>>..>>....>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>. (((((.(((....((((((((......(.(((...(.....)...)))...).....)))))).))..(........(.(((((...))))).)........)...))).))))). Cryo-EM image reconstruction of the 70S Ribosome Enterococcus faecalis Class03; 5S rRNA 6o8z a 1523 3.49 RF00177,RF01959,RF01960 URS00021ED954_1351 33004869 0003735 0005840 1351 ugagaguuugauccuggcucaggacgaacgcuggcggcgugccuaauacaugcaagucgaacgcuucuuggaaagaggaguggcggacgggugaguaacacguggguaaccuacccaucagagggggauaacacuuggaaacaggugcuaauaccgcauaacaguuuaugccgcauggcauaagagugaaaggcgcuuucgggugucgcugauggauggacccgcggugcauuagcuaguuggugagguaacggcucaccaaggccacgaugcauagccgaccugagagggugaucggccacacugggacugagacacggcccagacuccuacgggaggcagcaguagggaaucuucggcaauggacgaaagucugaccgagcaacgccgcgugagugaagaagguuuucggaucguaaaacucuguuguuagagaagaacaaggacguuaguaacugaacguccccugacgguaucuaaccagaaagccacggcuaacuacgugccagcagccgcgguaauacguagguggcaagcguuguccggauuuauugggcguaaagcgagcgcaggcgguuucuuaagucugaugugaaagcccccggcucaaccggggagggucauuggaaacugggagacuugagugcagaagaggagaguggaauuccauguguagcggugaaaugcguagauauauggaggaacaccaguggcgaaggcggcucucuggucuguaacugacgcugaggcucgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugagugcuaaguguuggaggguuuccgcccuucagugcugcagcaaacgcauuaagcacuccgccuggggaguacgaccgcaagguugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggucuugacauccuuugaccacucuagagauagagcuuucccuucggggacaaagugacagguggugcaugguugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuuauuguuaguugccaucauuuaguugggcacucuagcgagacugccggugacaaaccggaggaagguggggaugacgucaaaucaucaugccccuuaugaccugggcuacacacgugcuacaaugggaaguacaacgagucgcuagaccgcgaggucaugcaaaucucuuaaagcuucucucaguucggauugcaggcugcaacucgccugcaugaagccggaaucgcuaguaaucgcggaucagcacgccgcggugaauacguucccgggccuuguacacaccgcccgucacaccacgagaguuuguaacacccgaagucggugagguaaccuuuuuggagccagccgccuaaggugggauagaugauuggggugaagucguaacaagguagccguaucggaaggugcggcuggauca ...<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<<<<.....>>>>>.>>>>>......<<........<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<<....>>>>>>......>>.>.......<<<<<<<<....>>>>>>>>.......<<<<<<....>>>>>>.>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<<<<<<<.........<<<<<<<........>>>>>>>..........>>>>>>...>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<.......<<<<<<.....>>>>>>.....>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<<..<<<......>>>.....>>>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<<....>>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<.....<<<<<....>>>>>.....<......>...>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<......>>>>>...>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<..<<<<...<<.<<<<..<<<..<<.....>>.>>>.>>>>.>>..>>>>..>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ...((((..[.[[[..)))).(((..(((((..(((((((((....(((.(((..(((..((.((((((...)))))).)))))......(((.......(((((((..((...(((((((.(.((.....(((.((....)).)))......)).).......((((((((....)))))))).......((((((....)))))).)))))))..))))))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....((((((...(.....((((..(........)..)))).....)....))))))......((((([[[...(((((.....((.]]])).......))))))))))..))))).)))..........((([....(.((((...(((.(((((((.((((((((((......((((((.....))))))...).)))))))..)))))))))..(((.(((((...((((((((....(((((.(...((........))......).)))))....).......((....)).)))))))..)))))..))..))))...))))....((((((...((...((((.........))))...))))))))..........((((((..((((((((((((......))))))))))))...((...])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((......(((((....)))))......(......)...))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(........))))...)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...((((((......(((..(...((((....))))...)....)))......))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((..((((....(.((((..(((..((.....)).))).)))).)...))))..))))))..))).))))..).))...)..)..(((((((((....)))))))))...... Cryo-EM image reconstruction of the 70S Ribosome Enterococcus faecalis Class04; 16S rRNA 6o8z A 2903 3.49 RF02540,RF02541,RF00002 URS00021ED959_1351 33004869 0003735 0005840 1351 uuaagugaauaagggcgcacgguggaugccuuggcacuaggagccgaugaaggacgggacuaacaccgauaugcuuuggggagcuguaaguaagcuaugauccagagauuuccgaaugggggaacccaauaucuuuuauaggauauuacuuuucagugaauacauagcugauuagagguagacgcagagaacugaaacaucuuaguaccugcaggaagagaaagaaaauucgauucccugaguagcggcgagcgaaacgggaagagcccaaaccaacaagcuugcuuguugggguuguaggacuccgauaugguagucuguuaguauaguugaaggauuuggaaaauuccgcuaaagagggugaaagccccguagacgaaaugcugacaacaccuaggaggauccugaguacggcggaacacgagaaauuccgucggaauccgcggggaccaucccgcaaggcuaaauacucccuagugaccgauagugaaccaguaccgugagggaaaggugaaaagcaccccggaaggggagugaaauagauccugaaaccgugugccuacaacaagucaaagcucguuaaugagugauggcgugccuuuuguagaaugaaccggcgaguuacgauugcaugcgagguuaagucgaagagacggagccgcagcgaaagcgagucugaauagggcgaaugaguauguagucguagacccgaaaccaugugaucuacccauguccagguugaaggugcgguaaaacgcacuggaggaccgaacccacguacguugaaaagugcggggaugagguguggguagcggagaaauuccaaacgaacuuggagauagcugguucucuccgaaauagcuuuagggcuagccucggaauugagaaugauggagguagagcacuguuuggacuaggggcccaucggguuaccgaauucagauaaacuccgaaugccauucauuuauauccgggagucagacugcgagugauaagauccguagucgaaagggaaacagcccagaccaccagcuaaggucccaaaauauauguuaaguggaaaaggaugugggguugcacagacaacuaggauguuggcuuagaagcagccaccauuuaaagagugcguaauagcucacuagucgagugacccugcgccgaaaauguaccggggcuaaacauauuaccgaagcuguggacuacaccauuagguguagugguaggagagcguucuaagggcguugaaggucgaucgugaggacggcuggagcgcuuagaagugagaaugccgguaugaguagcgaaagacaggugagaauccuguccaccguaugacuaagguuuccuggggaaggcucguccgcccaggguuagucgggaccuaagccgaggccgauaggcguaggcgauggacaacagguugauauuccuguaccaguuguuuuuguuugagcaauggagggacgcaguaggcuaaggaaugcaugcgauuggaagugcauguccaagcaaugagucuugaguagaguuaaaugcuuuacucuuuaaggacaaguugugacggggagcgaaauaguagcgaaguuccugacgucacacugccaagaaaagcuucuagugagaaaacaacugcccguaccguaaaccgacacagguagucgaggagaguauccuaaggugagcgagcgaacucucguuaaggaacucggcaaaaugaccccguaacuucgggagaaggggugcugacuucggucagccgcagugaauaggcccaagcgacuguuuaucaaaaacacaggucucugcaaaaucguaagaugaaguauaggggcugacgccugcccggugcuggaagguuaagaggauggguuagcuucggcgaagcucagaauugaagccccaguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgacccgcacgaaaggcguaacgauuugggcacugucucaacgagagacucggugaaauuuuaguaccugugaagaugcagguuacccgcgacaggacggaaagaccccauggagcuuuacuguaguuugauauugaguguuuguaccacauguacaggauagguaggagccgaugagaccggaacgcuaguuucggaggaggcgcuggugggauacuacccuuguguuaugaacccucuaacccgcaccacuaaucguggugggagacagugucagaugggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguucccucagaaugguuggaaaucauucgaagaguguaaaggcagaagggagcuugacugcgagaccuacaagucgagcagggacgaaagucgggcuuagugauccggugguuccgcauggaagggccaucgcucaacggauaaaagcuacccuggggauaacaggcuuaucucccccaagaguccacaucgacggggagguuuggcaccucgaugucggcucgucgcauccuggggcuguagucggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucccuauccgucgcgggcguuggaaauuugagaggagcuguccuuaguacgagaggaccgggauggacuuaccgcugguguaccaguuguucugccaagggcauugcuggguagcuauguagggaagggauaaacgcugaaagcaucuaagugugaagcccaccucaagaugagauuucccauuucuuuaagaaaguaagaccccugagagaugaucagguagauagguuggaaguggaaggcuagugauaguuggagcggaccaauacuaaucggucgaggacuuaac 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Cryo-EM image reconstruction of the 70S Ribosome Enterococcus faecalis Class04; 23S rRNA 6o8z B 116 3.49 RF00001 URS0000240630_1351 33004869 0003735 0005840 1351 ugugguggcgauagcgagaaggauacaccuguucccaugccgaacacagaaguuaagcuucuuagcgccgauuguagugaaggguuucccuuugugagaguaggacgucgccacgc <<<<<<<<<....<<<<<<<<.....<<<<<<.............>>>>..>>....>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>..>>>>>>>>>. .((((((((....((((((((.....((.(((...(.....)...)))...))....)))))).))..(.........((((((...)))))).........)...)))))))).. Cryo-EM image reconstruction of the 70S Ribosome Enterococcus faecalis Class04; 5S rRNA 6o90 a 1528 3.49 RF00177,RF01959,RF01960 URS00021ED954_1351 33004869 0003735 0005840 1351 ugagaguuugauccuggcucaggacgaacgcuggcggcgugccuaauacaugcaagucgaacgcuucuuuccuuggaaagaggaguggcggacgggugaguaacacguggguaaccuacccaucagagggggauaacacuuggaaacaggugcuaauaccgcauaacaguuuaugccgcauggcauaagagugaaaggcgcuuucgggugucgcugauggauggacccgcggugcauuagcuaguuggugagguaacggcucaccaaggccacgaugcauagccgaccugagagggugaucggccacacugggacugagacacggcccagacuccuacgggaggcagcaguagggaaucuucggcaauggacgaaagucugaccgagcaacgccgcgugagugaagaagguuuucggaucguaaaacucuguuguuagagaagaacaaggacguuaguaacugaacguccccugacgguaucuaaccagaaagccacggcuaacuacgugccagcagccgcgguaauacguagguggcaagcguuguccggauuuauugggcguaaagcgagcgcaggcgguuucuuaagucugaugugaaagcccccggcucaaccggggagggucauuggaaacugggagacuugagugcagaagaggagaguggaauuccauguguagcggugaaaugcguagauauauggaggaacaccaguggcgaaggcggcucucuggucuguaacugacgcugaggcucgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugagugcuaaguguuggaggguuuccgcccuucagugcugcagcaaacgcauuaagcacuccgccuggggaguacgaccgcaagguugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggucuugacauccuuugaccacucuagagauagagcuuucccuucggggacaaagugacagguggugcaugguugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuuauuguuaguugccaucauuuaguugggcacucuagcgagacugccggugacaaaccggaggaagguggggaugacgucaaaucaucaugccccuuaugaccugggcuacacacgugcuacaaugggaaguacaacgagucgcuagaccgcgaggucaugcaaaucucuuaaagcuucucucaguucggauugcaggcugcaacucgccugcaugaagccggaaucgcuaguaaucgcggaucagcacgccgcggugaauacguucccgggccuuguacacaccgcccgucacaccacgagaguuuguaacacccgaagucggugagguaaccuuuuuggagccagccgccuaaggugggauagaugauuggggugaagucguaacaagguagccguaucggaaggugcggcuggauca ...<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<...<....<<<........>>>....>.>>>......<<........<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<<....>>>>>>......>>.>.......<<<<<<<<....>>>>>>>>........<<<<<....>>>>>..>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<<..........<<<..............>>.>..........>>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<.......<<<<<<.....>>>>>>.....>>>>>>>..>>>>>>>>>...<<.<<<<<...<<<<<<<....<<<<<<<<<..<<<......>>>.....>>>>>>>>>...........<<....>>.>>>>>>>..>>>>>..>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<<....>>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<.......<<<<<.....<<<<<....>>>>>................>>>>.>..<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<......>>>>>...>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<..<<<<...<<.<<<<..<<<..<<.....>>.>>>.>>>>.>>..>>>>..>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ...((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(..(((........)))..).)))))......(((.......(((((((..((...(((((((.(.((.....((((((....))))))......)).)........(((((((....)))))))........(.(.(......).).).)))))))..))))))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(.(((....)))..))))).)).))))))..((((......(.((....)).).....))))....((((((..........(...................)..........))))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......(((((.......)))))...).)))))))..)))))))))..((...((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))))....)..))))...))))....((((((...((...((((.........))))...))))))))..........((((((..((((((((((((......))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((.((......(((((....)))))......(......)...))..))).((.((....((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((.(((..(((..(........))))...))).)))..(..(((((.....))))).....)..)))).....).).)))...))..))))....)))))))...)).)))))))).(...(.((((......(((..((..((((....))))..))....)))......)))).)......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((..((((....(.((((..(((..((.....)).))).)))).)...))))..))))))..))).))))..).))...)..)..(((((((((....)))))))))...... Cryo-EM image reconstruction of the 70S Ribosome Enterococcus faecalis Class05; 16S rRNA 6o90 A 2903 3.49 RF02540,RF02541,RF00002 URS00021ED8EF_1351 33004869 0003735 0005840 1351 uuaagugaauaagggcgcacgguggaugccuuggcacuaggagccgaugaaggacgggacuaacaccgauaugcuuuggggagcuguaaguaagcuaugauccagagauuuccgaaugggggaacccaauaucuuuuauaggauauuacuuuucagugaauacauagcugauuagagguagacgcagagaacugaaacaucuuaguaccugcaggaagagaaagaaaauucgauucccugaguagcggcgagcgaaacgggaagagcccaaaccaacaagcuugcuuguugggguuguaggacuccgauaugguagucuguuaguauaguugaaggauuuggaaaauuccgcuaaagagggugaaagccccguagacgaaaugcugacaacaccuaggaggauccugaguacggcggaacacgagaaauuccgucggaauccgcggggaccaucccgcaaggcuaaauacucccuagugaccgauagugaaccaguaccgugagggaaaggugaaaagcaccccggaaggggagugaaauagauccugaaaccgugugccuacaacaagucaaagcucguuaaugagugauggcgugccuuuuguagaaugaaccggcgaguuacgauugcaugcgagguuaagucgaagagacggagccgcagcgaaagcgagucugaauagggcgaaugaguauguagucguagacccgaaaccaugugaucuacccauguccagguugaaggugcgguaaaacgcacuggaggaccgaacccacguacguugaaaagugcggggaugagguguggguagcggagaaauuccaaacgaacuuggagauagcugguucucuccgaaauagcuuuagggcuagccucggaauugagaaugauggagguagagcacuguuuggacuaggggcccaucggguuaccgaauucagauaaacuccgaaugccauucauuuauauccgggagucagacugcgagugauaagauccguagucgaaagggaaacagcccagaccaccagcuaaggucccaaaauauauguuaaguggaaaaggaugugggguugcacagacaacuaggauguuggcuuagaagcagccaccauuuaaagagugcguaauagcucacuagucgagugacccugcgccgaaaauguaccggggcuaaacauauuaccgaagcuguggacuacaccauuagguguagugguaggagagcguucuaagggcguugaaggucgaucgugaggacggcuggagcgcuuagaagugagaaugccgguaugaguagcgaaagacaggugagaauccuguccaccguaugacuaagguuuccuggggaaggcucguccgcccaggguuagucgggaccuaagccgaggccgauaggcguaggcgauggacaacagguugauauuccuguaccaguuguuuuuguuugagcaauggagggacgcaguaggcuaaggaaugcaugcgauuggaagugcauguccaagcaaugagucuugaguagaguuaaaugcuuuacucuuuaaggacaaguugugacggggagcgaaauaguagcgaaguuccugacgucacacugccaagaaaagcuucuagugagaaaacaacugcccguaccguaaaccgacacagguagucgaggagaguauccuaaggugagcgagcgaacucucguuaaggaacucggcaaaaugaccccguaacuucgggagaaggggugcugacuucggucagccgcagugaauaggcccaagcgacuguuuaucaaaaacacaggucucugcaaaaucguaagaugaaguauaggggcugacgccugcccggugcuggaagguuaagaggauggguuagcuucggcgaagcucagaauugaagccccaguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgacccgcacgaaaggcguaacgauuugggcacugucucaacgagagacucggugaaauuuuaguaccugugaagaugcagguuacccgcgacaggacggaaagaccccauggagcuuuacuguaguuugauauugaguguuuguaccacauguacaggauagguaggagccgaugagaccggaacgcuaguuucggaggaggcgcuggugggauacuacccuuguguuaugaacccucuaacccgcaccacuaaucguggugggagacagugucagaugggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguucccucagaaugguuggaaaucauucgaagaguguaaaggcagaagggagcuugacugcgagaccuacaagucgagcagggacgaaagucgggcuuagugauccggugguuccgcauggaagggccaucgcucaacggauaaaagcuacccuggggauaacaggcuuaucucccccaagaguccacaucgacggggagguuuggcaccucgaugucggcucgucgcauccuggggcuguagucggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucccuauccgucgcgggcguuggaaauuugagaggagcuguccuuaguacgagaggaccgggauggacuuaccgcugguguaccaguuguucugccaagggcauugcuggguagcuauguagggaagggauaaacgcugaaagcaucuaagugugaagcccaccucaagaugagauuucccauuucuuuaagaaaguaagaccccugagagaugaucagguagauagguuggaaguggaaggcuagugauaguuggagcggaccaauacuaaucggucgaggacuuaac 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Cryo-EM image reconstruction of the 70S Ribosome Enterococcus faecalis Class05; 23S rRNA 6o90 B 116 3.49 RF00001 URS0000240630_1351 33004869 0003735 0005840 1351 ugugguggcgauagcgagaaggauacaccuguucccaugccgaacacagaaguuaagcuucuuagcgccgauuguagugaaggguuucccuuugugagaguaggacgucgccacgc <<<<<<<<.....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<.....<.<<<<<<<<...>>>>>>>>...>...>>...>>>>>>>>. .((((((((....((((((((......(.(((...(.....)...)))...).....)))))).))..(.......((((((((...)))))))).......)...)))))))).. Cryo-EM image reconstruction of the 70S Ribosome Enterococcus faecalis Class05; 4S rRNA 6o97 1A 2871 2.75 RF02540,RF02541,RF00002 URS00001698E8_300852 30793894 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>....<<<<<.....<......>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<..<<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<....<<<<........>>..>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..<.......(......>>>>.........<<......>>.).>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<.......<<<<<<<<..>>>>>>>>....>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.((((((((...(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))).))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((.(..((..............)))..)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((..(...........)...))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((.(((((((((.(.........(((((..(((......(((((.((....)).)))))...)))............)))))).))))))))).))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((...)))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with propylamycin and bound to mRNA and A-, P-, and E-site tRNAs at 2.75A resolution; 23S Ribosomal RNA 6o97 1B 120 2.75 RF00001 URS000080DEE8_300852 30793894 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>. .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the Thermus thermophilus 70S ribosome in complex with propylamycin and bound to mRNA and A-, P-, and E-site tRNAs at 2.75A resolution; 5S Ribosomal RNA 6o97 1a 1500 2.75 RF00177,RF01959,RF01960 URS000080DFED_300852 30793894 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<......>>....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((..)))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..((((((((....((((((((....((((((....((........)).......))))))....).......((....)).)))))))...)))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((.(((....))).)))....(((....)))....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the Thermus thermophilus 70S ribosome in complex with propylamycin and bound to mRNA and A-, P-, and E-site tRNAs at 2.75A resolution; 16S Ribosomal RNA 6o97 1v 13 2.75 30793894 10665 aaaaaugguuuuc ............. ............. Crystal structure of the Thermus thermophilus 70S ribosome in complex with propylamycin and bound to mRNA and A-, P-, and E-site tRNAs at 2.75A resolution; mRNA 6o97 1w 73 2.75 RF00005 URS00003179F7_562 30793894 0030533 0006412 562 gggugaunagcucagggagagcaccucccunacnaggaggggnucggcggnucgaucccgucaucacccacca <<<<<<...<<<<.....>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>.>>>>>>.... (((((....((((...[.)))).(((((.......))))).....(((((..]....)))))..))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with propylamycin and bound to mRNA and A-, P-, and E-site tRNAs at 2.75A resolution; A-site and E-site tRNAs 6o97 1x 76 2.75 RF00005 URS000041AF00_562 30793894 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with propylamycin and bound to mRNA and A-, P-, and E-site tRNAs at 2.75A resolution; P-site tRNA 6o97 1y 73 2.75 RF00005 URS00003179F7_562 30793894 0030533 0006412 562 gggugaunagcucagggagagcaccucccunacnaggaggggnucggcggnucgaucccgucaucacccacca <<<<<<<..<<<<.....>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... ((((((...((((.....)))).(((((.......))))).....(((((.......))))).)))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with propylamycin and bound to mRNA and A-, P-, and E-site tRNAs at 2.75A resolution; A-site and E-site tRNAs 6o97 2A 2800 2.75 RF02540,RF02541,RF00002 URS00001698E8_300852 30793894 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<............>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<..>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<..>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<...<<......<<<<<<<<....>>>>>>>>...>>.............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>......>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (.(......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((...))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...((((((((.....))))))))....{.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).))))....(((((((((.[.....)))))))))....}.(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....(())....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((.(..(...............).)..))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((.().)))))))).))..........]]].)....))))))))))...)))))))(((((.(..).)))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...(((((((((((((.((.((.....)))).)))).....)))))))))..)))(...(((....))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((.(((((((.....))))))).))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((.((((((((.(.........(((((...((.......((((.((....)).))).)...)).............)))))).)))))))).)))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.((((...........))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....))))))).............(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....).) Crystal structure of the Thermus thermophilus 70S ribosome in complex with propylamycin and bound to mRNA and A-, P-, and E-site tRNAs at 2.75A resolution; 23S Ribosomal RNA 6o97 2B 120 2.75 RF00001 URS000080DEE8_300852 30793894 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>. ..(((((((((....((((((.(....(((((((...(.....)...))))..)))...).)))).))(((.......((((((((....)))))))).......))).))))))))).. Crystal structure of the Thermus thermophilus 70S ribosome in complex with propylamycin and bound to mRNA and A-, P-, and E-site tRNAs at 2.75A resolution; 5S Ribosomal RNA 6o97 2a 1503 2.75 RF00177,RF01959,RF01960 URS000080DFED_300852 30793894 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggau .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<...<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>...>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<.<<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<......>>....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((.(....).)))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((((((....))))))).(..(((....)))..).)))))))).((.((....((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...))..))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}... Crystal structure of the Thermus thermophilus 70S ribosome in complex with propylamycin and bound to mRNA and A-, P-, and E-site tRNAs at 2.75A resolution; 16S Ribosomal RNA 6o97 2v 13 2.75 30793894 10665 aaaaaugguuuuc ............. ............. Crystal structure of the Thermus thermophilus 70S ribosome in complex with propylamycin and bound to mRNA and A-, P-, and E-site tRNAs at 2.75A resolution; mRNA 6o97 2w 73 2.75 RF00005 URS00003179F7_562 30793894 0030533 0006412 562 gggugaunagcucagggagagcaccucccunacnaggaggggnucggcggnucgaucccgucaucacccacca <<<<<<...<<<<.....>>>>.<<<<<.......>>>>>......<<<<.......>>>>..>>>>>>.... ((((((...((((...[.)))).(((((.......))))).......(((..]....)))...)))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with propylamycin and bound to mRNA and A-, P-, and E-site tRNAs at 2.75A resolution; A-site and E-site tRNAs 6o97 2x 76 2.75 RF00005 URS000041AF00_562 30793894 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(.(((..]....))).)))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with propylamycin and bound to mRNA and A-, P-, and E-site tRNAs at 2.75A resolution; P-site tRNA 6o97 2y 73 2.75 RF00005 URS00003179F7_562 30793894 0030533 0006412 562 gggugaunagcucagggagagcaccucccunacnaggaggggnucggcggnucgaucccgucaucacccacca <<<<<<<..<<<<.....>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... ((((((...((((...[.)))).(((((.......))))).....(((((..]....))))).)))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with propylamycin and bound to mRNA and A-, P-, and E-site tRNAs at 2.75A resolution; A-site and E-site tRNAs 6o9j A 117 3.9 RF00001 URS000080DF7E_562 31108498 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggc <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>> (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))) 70S Elongation Competent Ribosome; 5S rRNA 6o9j B 2841 3.9 RF02540,RF02541 URS0000EEAD0C_562 31108498 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaacaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauggaaguguggacgccagucugcauggcuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.<...<<<...<<<.<<<<.......>>>>.>>>..>>.>...>.>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.......<<<<<..<<....>>...>>>>>.......>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<.....<<<<<<<<....>>>>>>>>....>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<<...>>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((...(((((((((.(...(((...(((.((((.......)))).)))..)).)...).)))))).)))...))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((..((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((.....{{{....)))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((((.(...(((((((......)))))))..).)))).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((...))))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). 70S Elongation Competent Ribosome; 23S rRNA 6o9j a 1530 3.9 RF00177,RF01959,RF01960 URS000080E24C_562 31108498 0003735 0005840 562 ugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggauca ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<<<..>>>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<.<.......>>>.>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<.<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>..>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((((((((..)))))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(...(((((((.(.......))).)))).)...)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))...((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.....]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... 70S Elongation Competent Ribosome; 16S rRNA 6o9j v 76 3.9 RF00005 URS00005AA258_562 31108498 0030533 0006412 562 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).(((((.......))))).....(((((..]....)))))))))))).... 70S Elongation Competent Ribosome; P-tRNA 6o9k a 1539 4.0 RF00177,RF01959,RF01960 URS000080DDC0_562 31108498 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<......>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..........>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<.<<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>..>>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<....<<<....>>>....>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((.((..).)))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..........)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((.(.........)))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((((.......)))))))).....)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))....(....)...))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((....(..(((.....)))).....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... 70S initiation complex; 16S rRNA 6o9k y 77 4.0 RF00005 URS00001BBAFC_562 31108498 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaagaucgucgguucaaauccggcccccgcaacca ..<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>...... ...((((..((((.........)))).(((((.......))))).....(((((.......)))))))))....... 70S initiation complex; tRNA 6o9k A 2854 4.0 RF02540,RF02541 URS000080DD2C_562 31108498 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauggaaguguggacgccagucugcauggcuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<........>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<.>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<......<.<<<<<......<<<<.......>>>>.............<<<......>>>..>>>>>.>..>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<<.....<<<<<<<<....>>>>>>>>..>>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>.>........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<.....<<<...<<<.<....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<..<<....>>...>>>>>..>....>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<.<<................<......>...............>>.>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<....<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>..>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<.........>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((.(((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((.(...).).))...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((......((...........))..........(....(......)..).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((.....].)))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((((((..(.......................................)..))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))(.((...(((((((...(((((.........))))).....((...[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].......((.((((.((..]]]]..)))))).)).....)}......))))..)))))).......((((.(.((((((...((.......))...))))))...)))).)........((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((....(((...(((((((((((}}}.))))))..)))))...)))..)))))...(((....(.((.....}.......)).)....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).)))))).)). 70S initiation complex; 23S rRNA 6o9k X 118 4.0 RF00001 URS0000366A67_562 31108498 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))). 70S initiation complex; 5S rRNA 6of1 1A 2871 2.8 RF02540,RF02541,RF00002 URS00001698E8_300852 30936109 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<....<<<<........>>..>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..<<.........>>...>>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<.<<....>>.>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...((((((((.....))))))))....{.(((((((((..(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).))))....(((((((((.[.....)))))))))....}.(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((.(...((..........)..).)..)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((..((.........))...))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((.(((((((((.(.........(((((..(((......(((((.((....)).)))))...)))............)))))).))))))))).))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((...)))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with dirithromycin and bound to mRNA and A-, P-, and E-site tRNAs at 2.80A resolution; 23S Ribosomal RNA 6of1 2A 2800 2.8 RF02540,RF02541,RF00002 URS00001698E8_300852 30936109 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>....<<<<<.....<......>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<.<<..........>>..>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<..>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<...<<......<<<<<<<<....>>>>>>>>...>>.............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....(())....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.(((..(...((..........))...)...))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((.().)))))))).))..........]]].)....))))))))))...)))))))(((((((..)))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........(((((...((......(((((.((....)).)))))...)).............)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....))))))).(((.))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with dirithromycin and bound to mRNA and A-, P-, and E-site tRNAs at 2.80A resolution; 23S Ribosomal RNA 6of1 1B 120 2.8 RF00001 URS000080DEE8_300852 30936109 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> (((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).))))))))))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with dirithromycin and bound to mRNA and A-, P-, and E-site tRNAs at 2.80A resolution; 5S Ribosomal RNA 6of1 1a 1500 2.8 RF00177,RF01959,RF01960 URS000080DFED_300852 30936109 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>.<..<<......>>.>..>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((((((....))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((..((((....))))..))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((((((....)))))))....(((....)))....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the Thermus thermophilus 70S ribosome in complex with dirithromycin and bound to mRNA and A-, P-, and E-site tRNAs at 2.80A resolution; 16S Ribosomal RNA 6of1 1v 13 2.8 30936109 10665 aaaaaugguuuuc ............. ............. Crystal structure of the Thermus thermophilus 70S ribosome in complex with dirithromycin and bound to mRNA and A-, P-, and E-site tRNAs at 2.80A resolution; mRNA 6of1 1w 73 2.8 RF00005 URS00003179F7_562 30936109 0030533 0006412 562 gggugaunagcucagggagagcaccucccunacnaggaggggnucggcggnucgaucccgucaucacccacca <<<<<<...<<<<.....>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>.>>>>>>.... (((((....((((...[.)))).(((((.......))))).....(((((..]....)))))..))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with dirithromycin and bound to mRNA and A-, P-, and E-site tRNAs at 2.80A resolution; A-site and E-site tRNAs 6of1 1x 76 2.8 RF00005 URS000041AF00_562 30936109 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with dirithromycin and bound to mRNA and A-, P-, and E-site tRNAs at 2.80A resolution; P-site tRNA 6of1 1y 73 2.8 RF00005 URS00003179F7_562 30936109 0030533 0006412 562 gggugaunagcucagggagagcaccucccunacnaggaggggnucggcggnucgaucccgucaucacccacca <<<<<<<..<<<<.....>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((....((((.....)))).(((((.......))))).....(((((.......)))))..))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with dirithromycin and bound to mRNA and A-, P-, and E-site tRNAs at 2.80A resolution; A-site and E-site tRNAs 6of1 2B 120 2.8 RF00001 URS000080DEE8_300852 30936109 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> .((((((((((....((((((.(....(((((((...(.....)...))))..)))...).)))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the Thermus thermophilus 70S ribosome in complex with dirithromycin and bound to mRNA and A-, P-, and E-site tRNAs at 2.80A resolution; 5S Ribosomal RNA 6of1 2a 1503 2.8 RF00177,RF01959,RF01960 URS000080DFED_300852 30936109 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggau .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<......>>....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>.... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((.(....).)))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((((((....))))))).(..(((....)))..).)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}... Crystal structure of the Thermus thermophilus 70S ribosome in complex with dirithromycin and bound to mRNA and A-, P-, and E-site tRNAs at 2.80A resolution; 16S Ribosomal RNA 6of1 2v 13 2.8 30936109 10665 aaaaaugguuuuc ............. ............. Crystal structure of the Thermus thermophilus 70S ribosome in complex with dirithromycin and bound to mRNA and A-, P-, and E-site tRNAs at 2.80A resolution; mRNA 6of1 2w 73 2.8 RF00005 URS00003179F7_562 30936109 0030533 0006412 562 gggugaunagcucagggagagcaccucccunacnaggaggggnucggcggnucgaucccgucaucacccacca <<<<<<...<<<<.....>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>.>>>>>>.... (((((....((((...[.)))).(((((.......))))).....(.(((..]....))).)..))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with dirithromycin and bound to mRNA and A-, P-, and E-site tRNAs at 2.80A resolution; A-site and E-site tRNAs 6of1 2x 76 2.8 RF00005 URS000041AF00_562 30936109 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with dirithromycin and bound to mRNA and A-, P-, and E-site tRNAs at 2.80A resolution; P-site tRNA 6of1 2y 73 2.8 RF00005 URS00003179F7_562 30936109 0030533 0006412 562 gggugaunagcucagggagagcaccucccunacnaggaggggnucggcggnucgaucccgucaucacccacca <<<<<....<<<<.....>>>>.<<<<<.......>>>>>.....<<.<<.......>>.>>..>>>>>.... (((((....((((...[.)))).(((((.......))))).....(..((..]....))..)..))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with dirithromycin and bound to mRNA and A-, P-, and E-site tRNAs at 2.80A resolution; A-site and E-site tRNAs 6of6 QA 1500 3.2 RF00177,RF01959,RF01960 URS000080E226_300852 32601241 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggggucuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<...>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<<....>>>>..>>>>>>>>.<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<...<<<.....>>>.>.....>>>>>>.....<<<<<....>>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((......((((((((..(((((((....)))))))....(((....)))...))))))))..((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.((((((....(...(((.....))))......)))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Crystal structure of tRNA^ Ala(GGC) bound to cognate 70S A-site; 16S rRNA 6of6 QV 77 3.2 RF00005 URS000041AF00_562 32601241 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of tRNA^ Ala(GGC) bound to cognate 70S A-site; P-site tRNAfMet 6of6 QW 76 3.2 RF00005 URS0001A24B5E_562 32601241 0030533 0006412 562 ggggcuauagcucagaagggagagcgcuugcaugccaugcaagaggucagcgguucgaucccgcuuagcuccacca <<<<<<<....<<........>>...<<<<.........>>>>.....<<<<<.......>>>>>>>>>>>>.... ((.((((....(...........)..((((.........)))).....(((((.......))))))))).)).... Crystal structure of tRNA^ Ala(GGC) bound to cognate 70S A-site; E-site tRNAAla(GGC) 6of6 QX 19 3.2 32601241 562 ggagguaaaaauggccaaa ................... ................... Crystal structure of tRNA^ Ala(GGC) bound to cognate 70S A-site; mRNA 6of6 QY 75 3.2 RF00005 URS00001C39A4_1354003 32601241 0030533 0006412 1354003 ggggcuauagcucagcugggagagcgcuugcauggcaugcaagaggucagcgguucgaucccgcuuagcuccacc <<<<<<...<<<<........>>>>.<<<<<<.....>>>>>>......<<<.........>>>..>>>>>>... ((.((.....(............)..((((((.....))))))......((.(........)))...)).))... Crystal structure of tRNA^ Ala(GGC) bound to cognate 70S A-site; A-site tRNAAla(GGC) 6of6 RA 2882 3.2 RF02540,RF02541,RF00002 URS00001698E8_300852 32601241 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>....<<<<<.....<<....>>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<..>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<.........>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<<.....>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[[)))...].((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...........)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((...((((((......)))).))...))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((........((((.((...(((.........)))...)).....(...((......)).).))))....)))))))))).))..........]]].)....))))))))))...)))))))(((((((.......)))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((.(((.....(((....))).......))).))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((.((((((((.(..........((((..(((......((((((((....))))))))...)))............)))).).)))))))).)))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(...((.....))......(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal structure of tRNA^ Ala(GGC) bound to cognate 70S A-site; 23S rRNA 6of6 RB 120 3.2 RF00001 URS00005F2F4B_300852 32601241 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> .((((((((((....((((((.(....(((((((...(.....)...))))..)))...).)))).))(((.......((.(((((....))))).)).......))).)))))))))). Crystal structure of tRNA^ Ala(GGC) bound to cognate 70S A-site; 5S rRNA 6of6 XA 1500 3.2 RF00177,RF01959,RF01960 URS000080E226_300852 32601241 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggggacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<...>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<......>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<......>>>..>>>>>>>>.<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((.....)))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).(((......)))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((((..(.(((((....))))).)...((((....))))..))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((.......(((.....)))......)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Crystal structure of tRNA^ Ala(GGC) bound to cognate 70S A-site; 16S rRNA 6of6 XV 77 3.2 RF00005 URS000041AF00_562 32601241 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of tRNA^ Ala(GGC) bound to cognate 70S A-site; P-site tRNAfMet 6of6 XW 76 3.2 RF00005 URS0001A24B5E_562 32601241 0030533 0006412 562 ggggcuauagcucagaagggagagcgcuugcaugccaugcaagaggucagcgguucgaucccgcuuagcuccacca <<<<<....<<<<........>>>>..<.............>......<<<<<.......>>>>>..>>>>>.... (((..(...(((..........)))........................((((.......))))...).))).... Crystal structure of tRNA^ Ala(GGC) bound to cognate 70S A-site; E-site tRNAAla(GGC) 6of6 XX 18 3.2 32601241 562 ggagguaaaaauggccaa .................. .................. Crystal structure of tRNA^ Ala(GGC) bound to cognate 70S A-site; mRNA 6of6 XY 75 3.2 RF00005 URS00001C39A4_1354003 32601241 0030533 0006412 1354003 ggggcuauagcucagcugggagagcgcuugcauggcaugcaagaggucagcgguucgaucccgcuuagcuccacc .<<<<<...<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<.........>>>>.>>.>>>... .((.((....(((........)))...(((((.....)))))........(...........)...))..))... Crystal structure of tRNA^ Ala(GGC) bound to cognate 70S A-site; A-site tRNAAla(GGC) 6of6 YA 2883 3.2 RF02540,RF02541,RF00002 URS00001698E8_300852 32601241 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<..>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<..>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<<..>>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<<.....>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((..)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...(((((((((..).))))))))....{.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).))))....(((((((((.[.....)))))))))....}.(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...........)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((...((.(((......)))..))...)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......(((((.(((..((...........))..))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((...(.........(((((..(((......((((((((....))))))))...)))............))))))...))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(..(((.....))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal structure of tRNA^ Ala(GGC) bound to cognate 70S A-site; 23S rRNA 6of6 YB 120 3.2 RF00001 URS00005F2F4B_300852 32601241 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> (((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).))))))))))) Crystal structure of tRNA^ Ala(GGC) bound to cognate 70S A-site; 5S rRNA 6ofx 3 1539 3.3 RF00177,RF01959,RF01960 URS000080DDC0_83333 31513010 0003735 0005840 83333 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<..........>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<.......<<<....>>>......>>>>...<.<<<<<.......<<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>.............>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......(((...[.[[[...))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((............))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....(((((......)))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((.(....(((((((...((........))......)))))))....).......((....))..))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...((((((....))))))..............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((...(((((((((((....((((((.((....((....))...))))))))...)))))))))))...))).))))..).))...)..)..(((((((((....)))))))))}........... Non-rotated ribosome (Structure I); 16S ribosomal RNA 6ofx 1 2903 3.3 RF02540,RF02541 URS0000BC4674_83333 31513010 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugucgaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((...<<<....<.<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>..>>>.........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<.<...>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<.....<.<<<<...<<<<<<.......>>>>.>>...>>>>.>....>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<..<...<<<.........>>>...>.........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<............>>>>>....>>>>>><<<<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>>.>>>>>.>>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<.<.<<<...<<<....>>>...>>>..>>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<...<<<<<<<<<<<....(((...>>>>>>....<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>........<<<<<....>>>>>....>>>>>....>>...>>>.>........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<..<<....>>...>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[.<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<.<...........<<<<<...<........<.<<<<......>>>>.>.....>.............>>>>>..>.>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<.........>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>...]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<.)))..>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<.........>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......((((.((((((((.(((...(((((......)))))[[......(((.....]])))...)))...)))))))).))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((((..)))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...).)))...(((.(((((........))))))))..).))))))))).(.((.......))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((((((.....))))).))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(.(.....{.(((((.(((..(.(.........).)..))).....(...((......)).).)))))...).)..))))).))...........]]].)...))))))))))...)))))))((((...(......)...))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((...(((...(((....)))...)))...)))..(((((........)))))]](((((((((((((...((((....((((..(((..(((((.(((((....{{{...))))).((..((((...((((((((((((.((.....))))))))))..))))..{))))...))(..(((.(....).)))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.[..).....)))))((((((.....(((....(((....})))....)))...))))))(...).......(((((((((...((.........))...(((((((.....(((....))).......))))))).]((((.(((..(((((((..(((........((.((..((....))...)).))........))))))))..)))))(.(((.........))).)........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.(....(..........((.(............(((..(......)..)))...................).)).)....).)))))))))))...((..((((((.....)))))).))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....((.(((..((..]]]]..)).))).)).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....((.((((....))).).))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Non-rotated ribosome (Structure I); 23S ribosomal RNA 6ofx 2 120 3.3 RF00001 URS00008116C5_83333 31513010 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((.(.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((.(((((...))))).)).......))...).)))))))). Non-rotated ribosome (Structure I); 5S ribosomal RNA 6ofx 5 77 3.3 RF00005 URS000041AF00_562 31513010 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(.(((.......))).)))))))..... Non-rotated ribosome (Structure I); tRNAfMet 6ofx 4 20 3.3 31513010 32630 aggagguaaaaaugugaaaa .................... .................... Non-rotated ribosome (Structure I); mRNA 6og7 3 1539 3.3 RF00177,RF01959,RF01960 URS000080DDC0_83333 31513010 0003735 0005840 83333 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<.<<<<<<....>>>>>.>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<.<...<<<<<<......>>>>>.>....>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>..<<.<<<<<......<.<<<<<<<<.......>>>>>>>>..>.......>>>>>....>>.<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<........<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>......>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<.<..<<<<<<.<<<...<<....>>..>>>>>>>>>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((.(...(....)...).).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..(......))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((.(((....)))....))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(..(.(((.((((.......)))).))).)...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(.(((((.(((((((((.......((((((.....)))))).....)))))))..))))))).)..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((.((((((((.....)))))))).)))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....))))))).............))))).))).((.((....((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...))..))))....)))))))...)).)))))))).(...((((((......(((..((...(((....)))...))....)))......))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... 70S termination complex with RF2 bound to the UGA codon. Non-rotated ribosome with RF2 bound (Structure II); 16S ribosomal RNA 6og7 1 2903 3.3 RF02540,RF02541 URS0000BC4674_83333 31513010 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugucgaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<.))).....>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<....<<<........>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<.<..>.>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<......<<...<<<.<<<<...<<<<<<.......>>>>.>>...>>>>.>>>..>>.......>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<..<...<<...........>>...>.........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<............>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>>....<<<....<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>....>>>.....<..<<<<......>>>>...>>>>>>...>>>...>>>.>........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<<.<......>..>>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[.<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<.............<<......<..........<<..........>>.......>................>>....>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>...]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<.)))..>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......((((.(((((.((.(((...(((((......)))))[[......(((.....]])))...)))...)).))))).))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...).)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((.(((.......)))..))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(.(.........).)..))).....(...((......)).).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((...(......)...))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((...(((...(((....)))...)))...)))..(((((........)))))]](((((((((((((...((((....((((..(((..(((((.(((((....{{....))))).((..((((...(((.((.(((((.((.....))))))).))...)))..{))))...))(..(((.(....).)))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.[..).....)))))((((((.....(((...((((....}))))...)))...))))))(...).......(((((.(((...((.........))...(((((((.....(((....))).......))))))).]((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).).))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((.((..(.(.............(..(............(.(..(......)..).)...................)..)....).)..)).)))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....((.((((....))).).))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(..((((.....)))).(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). 70S termination complex with RF2 bound to the UGA codon. Non-rotated ribosome with RF2 bound (Structure II); 23S ribosomal RNA 6og7 2 120 3.3 RF00001 URS00008116C5_83333 31513010 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). 70S termination complex with RF2 bound to the UGA codon. Non-rotated ribosome with RF2 bound (Structure II); 5S ribosomal RNA 6og7 5 75 3.3 RF00005 URS000041AF00_562 31513010 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaac .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>... .((((((..((((.........)))).(((((.......))))).....(((((.......)))))))))))... 70S termination complex with RF2 bound to the UGA codon. Non-rotated ribosome with RF2 bound (Structure II); tRNAfMet 6og7 4 20 3.3 31513010 32630 aggagguaaaaaugugaaaa .................... .................... 70S termination complex with RF2 bound to the UGA codon. Non-rotated ribosome with RF2 bound (Structure II); mRNA 6ogf 3 1539 3.9 RF00177,RF01959,RF01960 URS000080DDC0_562 31513010 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<......>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<....<<<<<<......>>>>>.>....>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<...<<<<<<.........>>>>>>.>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>..<<.<<<<<........<<<<<<<<.......>>>>>>>>..........>>>>>....>>.<<<<<(((...<<<<<.....<..))).>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<......>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<...<<....>>..>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((.((.(........).))..)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..(......))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((....(((((((...((((((.(...((........))......).))))))...).......((....)).))))))...))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((..(((((((....))))))).............))))).))).((.(((...((((((.(....((((((.((....))....(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....))))))))..)).)))))))).(...((((((......(((..((...(((....)))...))....)))......))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.(((...((....))..)))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... 70S termination complex with RF2 bound to the UGA codon. Partially rotated ribosome with RF2 bound (Structure III).; 16S ribosomal RNA 6ogf 1 2903 3.9 RF02540,RF02541 URS0000BC4674_562 31513010 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugucgaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<<..>>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<.......>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<...........>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<........>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<.<..<<<..<<<<<<<<<<<....(((...>>>>>>....<<<<...<<<<.<<<<<<<.<<.....>>>>>>>>>...>>>>...>>>>........<<<<......>>>>....>>>>>...>>>....>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<.....<<<.....<<.....>>.....>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<......<.<<<<<<.<<....>>..>>>>>>>.......>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<..............<<..<...............<<........>>.......................>.>>.....>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<.)))..>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<.........>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......((((((((((.((.(((...(((((......)))))[[......(((.....]])))...)))...)).))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...).)))...(((.(((((........))))))))..).))))))))).(.((.......))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((.(((.......)))..))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(.(.........).)..))).....(...((......)).).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((...(......)...))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((...(((...(((....)))...)))...)))..(((((........)))))]](((((((((((((...(.((....((((..(((..(((((((((((....{{{...))))))((..((((...((((((.(((((.((.....))))))).))..))))..[))))...))(..(((.(....).)))...))))))...)))...))))(..).....)).)...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((......((...((((....]))))...))....))))))(...).......(((((((((...((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((.........((((..((....))...)))).........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.(..............((..(............(.(..(......)..).)...................)..)).....).)))))))))))...((...(((((.....)))))..))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....((.((((....))).).))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). 70S termination complex with RF2 bound to the UGA codon. Partially rotated ribosome with RF2 bound (Structure III).; 23S ribosomal RNA 6ogf 2 120 3.9 RF00001 URS00008116C5_562 31513010 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. (.((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))).). 70S termination complex with RF2 bound to the UGA codon. Partially rotated ribosome with RF2 bound (Structure III).; 5S ribosomal RNA 6ogf 5 73 3.9 RF00005 URS000041AF00_562 31513010 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>. .((((((..((((.........)))).(((((.......))))).....(.(((.......))).))))))). 70S termination complex with RF2 bound to the UGA codon. Partially rotated ribosome with RF2 bound (Structure III).; tRNAfMet 6ogf 4 20 3.9 31513010 32630 aggagguaaaaaugugaaaa .................... .................... 70S termination complex with RF2 bound to the UGA codon. Partially rotated ribosome with RF2 bound (Structure III).; mRNA 6ogg 3 1539 4.2 RF00177,RF01959,RF01960 URS000080DDC0_562 31513010 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<<.[.((((>>>>>.<<<<.<<<<<..<<<<<<<......<<<.<<<..<<<..<<.<<..<<<.<<<<<<....>>>>.>>.>>>>>..>>>>>......<<..<....<<<<<<<..<<...<<<<<<<...<<.....<<<<<......>>>>>......>>.......<<......>>....<<<<<.<.<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<...<<<<<<.........>>>>>>.>>>......>>>..<<<<<<<<....>>>>...>>>>>>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<...<<<<<<....>>>>.>>>>...>.>>>>>>..<<<<.......<<<....>>>......>>>>...<.<<<<<........<<<<<<<<.......>>>>>>>>..........>>>>>....>..<<<<<(((...<<<<<.....<..))).>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<..<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>.>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<.<<<<<.....>>>>>.>>>>>>...<<..))>>.....>>>>>>.>>>.<<<.......<<<....>>>.....>>>..)))).]<<<<<.<<<<<<<..<..<<<<...<<<<<<<<<<......<<........>>..........<<<<<<<.......<<<<<<..<<<.<<......>.>>>>.............>>>>>.>...<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<..<<<<<<<...<....<.......>..>....>>>>>>>.....<<<<<.....>>>>>.........>>>.........>>>...>>>>>>>>....>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<....<<<....>>>....>....>>>.....>>>>>>>......<..<.<<<<<<<........>>>>>>>>...>......>>>>.....<<<<<<<.........>>>>>>>......>....>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<...<<....>>..>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((.(((..........)).).)))))..)))))......(((.......((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..(......))))))).)))))))..)).)))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((....(((((((...((((((((...((........))......))))))))...).......((....)).))))))...))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...((.(((....))).))..............))))).))).((.(((...((((((.(....(((((((((....)))..((((......))))..)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....(((.(..((((..((....)).)))).).)))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... 70S termination complex with RF2 bound to the UGA codon. Rotated ribosome with RF2 bound (Structure IV).; 16S ribosomal RNA 6ogg 1 2903 4.2 RF02540,RF02541 URS0000BC4674_562 31513010 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugucgaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<.))).....>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<.......<<<<<<<<<<<..<<<...<<<<.<.....>>>>>((......<<<.....))>>>...>>>....>>>>>>>>>>>....>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<<..>>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<........>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<......<<...<<<.<<<<...<.<<<.........>>>..>...>>>>.>>>..>>.......>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<...<........<<<<<.<....<<<.........>>>.....>.......<<<......>>>..>>>>>....>...>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<............>>>>>....>>>>>><<<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>.>>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<.<..<<<..<<<<<<<<<<<....[[....>>>>>>....<<<....<<<<.<<<<<<..<<.....>>.>>>>>>...>>>>....>>>........<<<........>>>....>>>>>...>>>....>>.>........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>.>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<..<<<..<<<<<<<..<<<........<<<<<<.<<....>>..>>>>>>........>>>>>>>>..>>>>><<<<<.........>>>>>........<...........<<<<<.......>>>>>.....>.....>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<..<<<...........<<<<<..<<.......<<<<............>>>>....>>............>>>>>..>>>..>>>>>>>>>>>...<<<.<<<<<.......>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<.<<<.<<<<<...<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>......>>>>..>...>>>..>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<...<<<<<<<<<<..]]..>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<.............>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((.(((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((.......(((((((((.((.(((...(((((......)))))[[......(((.....]])))...)))...)).)))))))))....))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((((..)))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((.(......).))))...).)))...(((.(((((........))))))))..).))))))))).(.((.......))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...((..((((...((.(((.......)))..))...))))..))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(.(.........).)..))).....(...((......)).).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((..(......)..)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((...(((...(((....)))...)))...)))..(((((........)))))]](((((((((((((...((((....((((..(((..(((((((((((....{{....))))))((..((((...(((.((.(((((.((.....))))))).))...)))..[))))...))(...((.(....).))....))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((.(((...((.........))....((((((.....(((....))).......))))))..}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).).))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((((((((..................(..(............(....(......)....)...................)..).........))))))))))...(((..(((((.....))))).)))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((.(((..((.((((((......))))))...)).(((((.....))))).....))).)..)...))..).....((.((((....))).).))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).)))))).)). 70S termination complex with RF2 bound to the UGA codon. Rotated ribosome with RF2 bound (Structure IV).; 23S ribosomal RNA 6ogg 2 120 4.2 RF00001 URS00008116C5_562 31513010 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. (.((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))).). 70S termination complex with RF2 bound to the UGA codon. Rotated ribosome with RF2 bound (Structure IV).; 5S ribosomal RNA 6ogg 5 73 4.2 RF00005 URS000041AF00_562 31513010 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgca .<<<<<<..<<<<.........>>>>.<.<<<.......>>>.>.....<<<<<.......>>>>>>>>>>>. .((((((..((((.........)))).(((((.......))))).....(.(((.......))).))))))). 70S termination complex with RF2 bound to the UGA codon. Rotated ribosome with RF2 bound (Structure IV).; tRNAfMet 6ogg 4 20 4.2 31513010 32630 aggagguaaaaaugugaaaa .................... .................... 70S termination complex with RF2 bound to the UGA codon. Rotated ribosome with RF2 bound (Structure IV).; mRNA 6ogi 3 1539 3.4 RF00177,RF01959,RF01960 URS000080DDC0_562 31513010 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<.<<<<<......>>>>>..>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<......<<<<......>>>>.......>>.>.....<<<....>>>....<<<<<.<.<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<.<<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>..<<.<<<<<......<.<<<<<<<<.<...>.>>>>>>>>..>.......>>>>>....>>.<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>.>..<<<<<<<<...<<<<<<<.....<<<.<<....<<<......>>>.......>.>>>>............<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<.<<<<<<<.....>>>>>>>.>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<..<<<<<...<<<<<<<..<......<<........>>..........<<<<<<........<..<<<..<<.<.<<....>>..>>>...<<....>>..>>>...>...<..<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<..<<<<<<....<...<<<.....>>>.>.....>>>>>>.....<<<<<.....>>>>>.........>>>.........>>>...>>>>>>>......>>>>>>...>...>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>...........<<<<..............>>>>...........>>>>>....<<<<<<...........>>>>>>.......>...>>>>>>>>>>.>>....<..<<...<<<<.<<<..<<<<<<<<<<<<....<<<<...<<<...<<....>>..>>>..>>>>...>>>>>>>>>>>>..>>>.>>>>....>>...>.....<<<<<<<<<....>>>>>>>>>............ .......(((...[.[[[...))).((((.(((((..(((((((((....(.(.((...(((.....(.......(....(....)....)......)....)))......(((......(((((((..((....((((((.(.((.....(((.(......).)))......)).).....(((....)))....(((.(...((....)).).))).))))))...)).)))))))(((......(..((((((((.......)))))))))........)))..(((((((......)))...))))))).(((((............))))).((((....))))....))).).).....(.(((...((((......))).))))).)).))))))..((((......(.((....)).).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[....(((((.....((..]])).......))))))))))..)))))))))..........((([[...(.((((...(((..((((((...(((((((.......(((.((.....)).))).....)))))))....))))))...(((((((((...((..((.......(...(........................)..).............((....))..))..))..))).)))))..))))...))))....((((((...((...(...............)...))))))))......{...((((((..((((..((((((.....))))))..))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.((((..(...(.(((.....(((.(..(.......((........))..........(((.((...(........((......(((....)).)................))......)..........((..(..(....(((((((((....)))....((......))....)))))).....((.(...(...(.......((.......))......)...)....(..(((.(.....).))).....)..).)).....)...).....))...........)).)))....)...).)))..(...(((((((.....(((..((...(((....)))...))....))).....)))))))............((................))........)....))))....(((((((.........)))))))...........)..))))))).))....(..((...((((.(((..((((((((((((....((((...((....((....))...))..))))...))))))))))))..))).))))....))...).....(((((((((....)))))))))}........... 70S termination complex with RF2 bound to the UAG codon. Rotated ribosome conformation (Structure V); 16S ribosomal RNA 6ogi 1 2903 3.4 RF02540,RF02541 URS0000BC4674_562 31513010 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugucgaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<.<.....>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<.....<.<<<<...<<<<<.........>>>.>>...>>>>.>....>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<.........>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<..<<....>>..>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<.<.<<<...<<<....>>>...>>>..>>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><...<<<....<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>....>>>....><..<<<<......>>>>...>>>>>>...>>>...>>>.>........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<.<..<<....>>...>.>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[.<<<<..<<<<<.<<<.<<<<<.<<<<<.<..<<.................<<.<............<<..............>>...................>.>>........>>..>.>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<...........>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>...]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<.)))..>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((.(......).)))[[......(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((((..)))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...).)))...(((.(((((........))))))))..).))))))))).(.((.......))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((((((.......)))).))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(.(.....{.(((((.(((..(.(.........).)..))).....(...((......)).).)))))...).)..))))).))...........]]].)...))))))))))...)))))))(((((..(......)..)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((...(((...(((....)))...)))...)))..(((((........)))))]]((((((((((.((...((((....((((..(((..(((((.(((((....{{{...))))).((..((((...(((((.((((((.((.....)))))))).)..))))..[))))...))(...((.(....).))....))))))...)))...))))(..).....))))...)).....)))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((...((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((.....((.................(.......................................................)........)).....))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))(.((...(((((((......(...........)........((.[.[[[))....)))))))...((((....(...{..)....)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)........((.((((((..((((((((........)))))..))).(((((.....))))).....)))))..)...))........((.((((....))).).))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((.......))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). 70S termination complex with RF2 bound to the UAG codon. Rotated ribosome conformation (Structure V); 23S ribosomal RNA 6ogi 2 120 3.4 RF00001 URS00008116C5_562 31513010 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((.(.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((.(((((...))))).)).......))...).)))))))). 70S termination complex with RF2 bound to the UAG codon. Rotated ribosome conformation (Structure V); 5S ribosomal RNA 6ogi 5 74 3.4 RF00005 URS000041AF00_562 31513010 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaa .<.<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>.>.. .((((((..((((......[..)))).(((((.......))))).....(((((..]....))))))))))).. 70S termination complex with RF2 bound to the UAG codon. Rotated ribosome conformation (Structure V); tRNAfMet 6ogi 4 20 3.4 31513010 32630 aggagguaaaaaugugaaaa .................... .................... 70S termination complex with RF2 bound to the UAG codon. Rotated ribosome conformation (Structure V); mRNA 6ogz B 18 3.6 URS0000E60BC2_28875 31101900 28875 uauauauauauauauaua .................. .................. In situ structure of Rotavirus RNA-dependent RNA polymerase at transcript-elongated state; RNA (5'-R(P*UP*AP*UP*AP*UP*AP*UP*AP*UP*AP*UP*AP*UP*AP*UP*AP*UP*A)-3') 6ogz C 17 3.6 URS0000E60B87_28875 31101900 28875 auauauauauauauaua ................. ................. In situ structure of Rotavirus RNA-dependent RNA polymerase at transcript-elongated state; RNA (5'-R(P*AP*UP*AP*UP*AP*UP*AP*UP*AP*UP*AP*UP*AP*UP*AP*UP*A)-3') 6oig 5 3243 3.8 RF02540,RF02543 URS0000A7632E_4932 33219089 0003735 0005840 4932 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaugguguuuuguauuucacuggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguagugagggucgcuugcuacaacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauagaggguguagaauaagugggagcuucggcgccagugaaauaccacuaccuuuauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..<<<...........<<.<<<<<<...>>>>>>.>>.............<<<<<<<.<<<.<<<.<<<<<<<..........<<<<......>>>>.........<<<.......>>>.........>>>>..>>>>>>......>>>>>>>>>>........<<<<<<<........>>>>>>>.....<<<<<...{.(((>>>>>..>>>..................................<<....>>...............<<<......>>>..................................<<<<<.<<.<<.<.......................<<<<<<<.<<<<<..<<<<<<<<......<<<<.<<<.......<<<........>>>........>>>.>>>>....>>>>>.>>>..>>>>>........<<<....>>>.....>>>>>>>....>>>.>>.>>>>>..<<<<........>>>><<<<<<...<.<<<<<.<<<<<<..<<....<<<<.....>>>>....>>...<......>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<.<<<....<....>....>>>..>>.>>....>>>>>>.>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<......<<<....>>><.<..<<<<<<<...<<<.<<<<<<..<...<<<....<<.....<<<<...<.<<<<.....>>>>>..>>>>.....>>..>>.>...>..>>>>...<<<<...<...........>...>>>>.....>>>>>.>>>>>>>...>>.<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<......<..<<<<.<<....<<.........>>....>>.........<<......>>...>>>>..>..>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><..<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>...>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<.........<<<....>>>..........<.............>.............>>...<<<<<........>>>>>))<<<<.<<<<<.<.....<<<....>>>........<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..[[[..>>>>>>....<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>.....<<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>...........>..>.>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<.......>>>..>>>>..<<<<.....<<<<<<<..................<<<<<...............>>>>>...<<<<<<<<<<..........................>>>>..>>>>>>...............<<<<<<<<<..<<<.........>>>...<<<<<<.....<<<.....>>>.......>>>>>>....<<..<<<..<<<<<<.<..........<<<<....>>>>........>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<.........>>>>.....>.....>>....>>.>>>>>>>........>>>>>>>..>>>>>>....>>....<<<<..........>>>>.....<<<<..<<<.<<......<<<<.<.<<<<..<<<<....<<<<<<...<<<<<<....<<...................................................>>.....>>>>>>......<<<.....<<<<..<..<........>..>...............<<<<<<....>>>>>>..>>>>..>>>......>.>>>>>.....>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<..[.((>>....>>>>>>>...<<<..<<<<.......>>>>..>>>.<<<....>>>.>>))].......<<<<<<..<<<<.))).}.>>>>>>>>>>..........>>>>...>>>>>....<..<<.<...<<<<<....<<.......>>....>>>>>....>..>>.>.......<<<..<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.<.....>.>>>.....>>>>>......>>>.......<<<<<<<....>>>.>>>>....>>..>>>.>>>>.....<<<<<<<<..<<<....<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<.]]]..>>>>..>>>>>..>.>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>..>>>....>>>>>>>>.......<<<<...<<<.<.....<<..........<<<<.........>>>>......>>.......<<.<<....<.....<..<<<......>>>..>....>...>>.>>..............>>.>>...>>>>..<<<<<.....................<<<<<.<<<.<<<.....<<<....<<<<<......>>>>>...>>>....>>>....>>>..>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((..(((.((..(((.((((((((...(.((((......)))))[[(...).(((.....]])))....))))))))...)))..).)....))).))))))...)....(((((((........))))))).....((.((..[..[[[)).))..)))..................................((....))............(..((((....))))..(......)..).....................(((((.(.(.(.........................(((((((((((((((((((((((.......(((.(((......((((........)))).......))).))).....))))).))))))))))........(((....)))....)))))))).....).).).))))).[((((........))))((((((....(.((((.((((((..(((...((((.....))))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).)))).)..((.(...((((((.....(((((.(((..(.(....(((((((....)))))))....[).)....((..((.((........)))).)).....))).))))).(..(.......)....)..))))))......).))..((((((....(.(((....))).)..((((((((...(((.(((((((.....(((....(((..(.((((...(.((((.....)))).).)))).)..)))..)).).....)))))...((((..(((.(......))))..)))).....))))).)))))))).....((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.......(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))((((((((...........))))))))....))))))((((((((.(.((......((((.((((....))))))))...))).)))))).)).....))))))((.....((.....((((((.......))))))((((.....((((..((...((((((...((.....)).))))))....[[(((.((...((....((......)).........(.(.(........)..).)....))....))...(((((........)))))]]((((.(((((..(...(.((....))....(...((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((......((.....))......))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....)...).)))))))).)))..)).....((......)).)))).(((.......)))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((((....(...........).........))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...(......((((....))))......).)))))..)))))(((((.........)))))........(...........(((((.......))))).....)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..((((..((((((((..(((((((.......((..................(......)...................))........))))))).....(((.....((((..(((..........)))................(.(((....))).)...))))..))).......))))))))...))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..(((.....{...)))..))).(((....))).))]]].].....((((((..((((.]]]..]))))))))))....)}....))))..)))))).......(..(....(((((...((.......))...))))).....)...)........(.((.((.(((..(.(((((((......))))))..).).(((.(.....).))).....))).)..)...))..).....(((((((....))).))))....))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....(((((((.((}}..)).))..)))))...))))..))))).((((...((((.............))))...)))).))))....)))))))).......((((...(((.((....((.(........(((((((..).)))))).....))).......((.(((......((.(..(((......)))..).))....))).)).............)).)))...))))..(((((.(..(.......)..)...(.(((((.(((.((.....((((.(..((((((..)..)))))..)))))....))....)))..)))))).))))).. Subunit joining exposes nascent pre-40S rRNA for processing and quality control; 25S ribosomal RNA 6oig 8 158 3.8 RF00002 URS00001BF64E_4932 33219089 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<<((....>>>>.......<<<......))..............>>>......>>>....<<.....>><<<<<.<<<....>>>.>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Subunit joining exposes nascent pre-40S rRNA for processing and quality control; 5.8S ribosomal RNA 6oig 7 121 3.8 RF00001 URS000055688D_4932 33219089 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<.....<<<<<<<<.....<..<<..............>>.....>....>>>>>>.>>.<<<<<.......<<.<<..<<....>>.>>.>>.....>>>>>..>>>>>>>>. (.(((((((....((((((((.....((((((...(....)...))).)..))....)))))).)).(((((.......(((((..((....)).))))).....))))).))))))).). Subunit joining exposes nascent pre-40S rRNA for processing and quality control; 5S ribosomal RNA 6oj2 QA 1500 3.2 RF00177,RF01959,RF01960 URS000080E226_300852 32601241 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggggucuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<<<<<<<<...>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>....<<<<.<<<<<....>>>>>.>>>>...<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<......>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((.(....).)))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(.(((....)))..))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((.(((((...))))).))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......(..........)..........(((((((......((((((((..(((((((....)))))))....((......))...))))))))..((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.((((.((.......(((.....)))......)).)))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((..........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Crystal structure of tRNA^ Ala(GGC) bound to the near-cognate 70S A-site; 16S rRNA 6oj2 QV 77 3.2 RF00005 URS000041AF00_562 32601241 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(.(((..]....))).)))))))..... Crystal structure of tRNA^ Ala(GGC) bound to the near-cognate 70S A-site; P-site tRNAfMet 6oj2 QW 76 3.2 RF00005 URS0001A24B6F_562 32601241 0030533 0006412 562 ggggcuauagcucagaagggagagcgcuugcauggcaagcaagaggucagcgguucgaucccgcuuagcuccacca <<<<<<<..<<<<........>>>>.<<<<.........>>>>.....<<<<<.......>>>>>>>>>>>>.... ((.((((..(((..........))).(((...........))).....(((((.......))))))))).)).... Crystal structure of tRNA^ Ala(GGC) bound to the near-cognate 70S A-site; E-site tRNAAla(GGC) 6oj2 QX 19 3.2 32601241 562 ggagguaaaaauggcaaaa ................... ................... Crystal structure of tRNA^ Ala(GGC) bound to the near-cognate 70S A-site; mRNA 6oj2 QY 75 3.2 RF00005 URS00001C39A4_562 32601241 0030533 0006412 562 ggggcuauagcucagcugggagagcgcuugcauggcaugcaagaggucagcgguucgaucccgcuuagcuccacc <<<<<<...<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>.>>>>>>... ((.(((....(............)...(((((.....)))))........(((.......)))...))).))... Crystal structure of tRNA^ Ala(GGC) bound to the near-cognate 70S A-site; A-site tRNAAla(GGC) 6oj2 RA 2882 3.2 RF02540,RF02541,RF00002 URS00001698E8_300852 32601241 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<....<<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>....<<<<<.....<......>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>.............>....>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<..>...>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<....<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.....>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<<........<.....<<<<<....<<..>>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>.>>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<.............>>>>....>>>.>>>>.......>>>>>>>...<<<.....>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[[)))...].((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...((((((((.....))))))))....{.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).))))....(((((((((.[.....)))))))))....}.(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....(())...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((...(((((........))).))...))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((........((((..(...(((.........)))...)......(...((......)).).))))....)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(((((((...(((......(((((.(((....))))))))...)))..))))).)).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........(((((..(((......((((((((....))))))))...)))............)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(..(.(.....).).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal structure of tRNA^ Ala(GGC) bound to the near-cognate 70S A-site; 23S rRNA 6oj2 RB 120 3.2 RF00001 URS00005F2F4B_300852 32601241 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).)))))))))). Crystal structure of tRNA^ Ala(GGC) bound to the near-cognate 70S A-site; 5S rRNA 6oj2 XA 1500 3.2 RF00177,RF01959,RF01960 URS000080E226_300852 32601241 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggggacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<...<..<<<.<<<..<<<..<<.<<<<<<<<<...>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>...>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<......>>>..>>>>>>>>.<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<.<.<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((.(.).)))))))).)))))......(((......((((((((..((...(((((((.(((((....((((.(....).)))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).(((.(...))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......(..........)..........(((((((..(...(((((.((..(((((((....)))))))....(((....)))...)).)))))).((.(((...((((((.(....((((((.((....))....(((......)))...)))))).....((((.(((((((.......(((.....)))......))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Crystal structure of tRNA^ Ala(GGC) bound to the near-cognate 70S A-site; 16S rRNA 6oj2 XV 77 3.2 RF00005 URS000041AF00_562 32601241 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of tRNA^ Ala(GGC) bound to the near-cognate 70S A-site; P-site tRNAfMet 6oj2 XW 76 3.2 RF00005 URS0001A24B6F_562 32601241 0030533 0006412 562 ggggcuauagcucagaagggagagcgcuugcauggcaagcaagaggucagcgguucgaucccgcuuagcuccacca <<<<<<<..<<<<........>>>>..<<...........>>......<<<<<.......>>>>>>>>>>>>.... ((.((((..(((..........))).......................(((((.......))))))))).)).... Crystal structure of tRNA^ Ala(GGC) bound to the near-cognate 70S A-site; E-site tRNAAla(GGC) 6oj2 XX 17 3.2 32601241 562 ggagguaaaaauggcaa ................. ................. Crystal structure of tRNA^ Ala(GGC) bound to the near-cognate 70S A-site; mRNA 6oj2 XY 76 3.2 RF00005 URS00001C39A4_562 32601241 0030533 0006412 562 ggggcuauagcucagcugggagagcgcuugcauggcaugcaagaggucagcgguucgaucccgcuuagcuccacca <<<<<<...<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>.>>>>>>.... ((.(((...((((........)))).((.(((.....))).)).....(.(((.......))).).))).)).... Crystal structure of tRNA^ Ala(GGC) bound to the near-cognate 70S A-site; A-site tRNAAla(GGC) 6oj2 YA 2883 3.2 RF02540,RF02541,RF00002 URS00001698E8_300852 32601241 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<..>>>>>>.>>....<<<<<.....<......>......>>>>>.....<.....<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>..>>>....>.>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<..>...>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<<.....>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((..)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...(((((((((..).))))))))....{.(((((((((......(...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)..)))))).))))....(((((((((.[.....)))))))))....}.(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....(..)...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((...((((((......)))).))...))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......(((((..(...(.............)...)......(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........(((((..(((......(((((.((....)).)))))...)))............)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....((((((..((..]]]]..)).)))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(..(((.....))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal structure of tRNA^ Ala(GGC) bound to the near-cognate 70S A-site; 23S rRNA 6oj2 YB 120 3.2 RF00001 URS00005F2F4B_300852 32601241 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> (((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).))))))))))) Crystal structure of tRNA^ Ala(GGC) bound to the near-cognate 70S A-site; 5S rRNA 6oj6 T 14 4.2 URS0000E60BCF_444185 31233764 444185 uguggcagagagcg .............. .............. In situ structure of rotavirus VP1 RNA-dependent RNA polymerase (DLP_RNA); Template 6oj6 U 10 4.2 URS000080E009_444185 31233764 444185 cgcucucugc .......... .......... In situ structure of rotavirus VP1 RNA-dependent RNA polymerase (DLP_RNA); Transcript 6okk A 1608 3.3 RF01960,RF01959,RF00177 URS000040971D_36329 24913268 0003735 0005840 36329 aaccugguugaucuugccaguagucauaugcuugucucaaagauuaagccaugcaagugaaaguauauauauauauauguagaaacugcgaacggcucauuaaaacaguuauagucuacuugacauuuauaaggauaacuacggaaaagcuguagcuaauacuugcauuauccuuuuggauaaguauuuguuagaaggaauuauaacaaagaaguaacacguaaaguguguaucaaucgaguuucugaccuaucagcuuuugauguuaggguauuggccuaacauggcuaugacggguaacggggaauuagaguucgauuccggagagggagccugagaaauagcuaccacaucuaaggaaggcagcaggcgcguaaauuacccaauucuaaagaagagagguagugacaagaaauaacaaugcaagguuuguauuggaauggugggaauuuaaaaccuucccagaguaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaauuguugcaguuaaaacgcucguaguugaauuucaaagaaucauucuuuuuaaaauccggauuuguuacuuugaguaaauuagaguguucaaagcaaacaguuaaagcauuguguuugaauacuauagcauggaauaacaaaauugaacaagcuaaaauuuuuuguucuuauuuuggcuuaguuacgauuaauaggaguagcuuggggacauucguauucagaugucagaggugaaauucuuagauuuucuggagacgaacaacugcgaaagcauuugucuaaaauacuuccauuaaucaagaacgaaaguuaagggagugaagacgaucagauaccgucguaaucuuaaccauaaacuaugccgacuagguguuggaugaagugcuuccuucaguaccuuaugagaaaucaaagucuuuggguucuggggcgaguauucgcgcaagcgagaaaguuaaaagaauugacggaagggcaccaccaggcguggagcuugcggcuuaauuugacucaacacggggaaacucacuaguuuaagacauuggauggugaugcauggccguuuuuaguucgugaaugauuugucugguuaauuccgauaacgaacgagaucuuaaccugcuaauuagcggcgaguacacuguacuugcugcuucuuagaggaacauugugugucuaacacaaggaaguuuaaggcaacaacaggucugugauguccuuagaugaacuaggcugcacgcgugcuacacugauauauauaacgaguaaaauaugcuugcauacuuuuccuccgccgaaaggcguagguaaucuuuaucaauauauaucgugauggggauagauuauugcaauuauuaaucuugaacgaggaaugccuaguaagcaugauucaucagauugugcugacuacgucccugcccuuuguacacaccgcccgucgcuccuaccgauugaaagauaugaugaauuguuuggacaagaaaaauuuuuucuggaaaaaccguaaauccuaucuuuuaaaggaaggagaagucguaacaagguuuccguaggugaaccugcggaaggaucau ...<<<<<.[.((((>>>>><<<<.<<<<<<...<<<...<......<<<.<<<..<<....<<...<<<<<<..>>>>>>...>>.>>......<<..<.....<<<..<<..<<...<<<<........<<.....<<<<<<.....>>>>>>......>>....<<<<<<....>>>>>>...<<<<<<<.<......>.>>>>>>>.......<<<.....>>>....>>>>..>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<<<<<<....>>>>...>>>>>>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>..>>>..>....>>>.....<<<<<<<<<.>>>>>>>>>......<<<<<<.........>>>>>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>>>>>.........<<<((.....<.<<...<<<.<<....<<<<.<....>.>>>>..<<<<<..>>>>><<<<<<.<<.......<<...<.......>.<<<<.......<<<.>>>>>>>...>>......>>.>>..>>>>.....<.<<<.<<.<.<<<.<..........>.>>>.>.>>.>>>..>.>>....<<<<<<..<<..<<<<<..<<<.<<<<<<.<...<<<......>>>......>.>>>>>.>>>>.......<<....>>...>>>>>.>>.>>>.>>>...>>>...>>.>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<<<<<<<<.<<<<..>>>>.>>>>>>>>>>...<<..))>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<<<....<...>...<<.<<<..<<<<<<<<<....<<<<<<<<<...>>>...<<<......>>>...>>>>>>....<<<<<.<<<..<<<..<<<<<<<<<<<<...>>>>>>>>>>>>..>>>.>>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>...>.>>>>>>>.....>>>>>>>...>>.>>>>.>>>.....<<<<<<<<.....<<.<<<.<<<<<..>>>>>.>.>><<<.<<<<....>>>>.>>>....>>.......>>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<<.<<....<<<<<<<<.<<<..<<.<<<<...<<.<<<<<.>>>.>>.>>...>>>>.>>..>>>.>>>>>>>>...>>.>>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>....... ...((((..[.[[[..))))((((.((((((...(((...((.....(((.(((..((....((...((((((()))))))...))[))......(((.......(((..((..((...((((....[...((.....((.(((.....))).))......))....((((((....))))))...(((((((.(......).))))))).....(](((.(..)))))...))))..))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)....))).....(((((((((.)))))))))....(.((((((.........))))))......)..((((([[....(.((((.....((..]])).......))))))))))..))))))))))..[......((([[...(.(.((...(((.((....(((..(....)..)))..(((((())))))((((((.((.......((..((.......)).(((.......(((.))))))....))......)).))..)))).....(..((.(..(.(((.(..........).))).)..).))...).))...(((((((..((..(((((..(((.((((((.....((........))........)))))).))).......((....))...))))).)).))).)))..))))...)).)....((((((...((...((((.........))))...))))))))......{...(((.((.((((((((((.((((())))).))))))))))...((..]]))...))...].))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((((....(...)...((.(((...(.((((((....(((((((((...)))..(.((......)))...)))))).....((((.(.(..(((..((.(((((((((...))))))))).))..))).).)..(.((((((.....))))))....)..)))).....))).))).....).))))).....)))))))...)).)))).))).(...((((((.......((...(.(((((..))))).)...((..((((....))))..))....)).........))))))......(....(((.((..........)).)))....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(.(((((.((..(.((.(((((.(((..((.((((...(...((((.))).)...)...)))).))..))).))))).)))..)).)))))..).))...)..)..(((((((((....)))))))))}...... Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine, small subunit; 18S ribosomal RNA 6okk g 74 3.3 RF00005 URS000035398D_36329 24913268 0030533 0006412 36329 ggguaauuggcgcaguugguuagcgcgcgggucucauaaucccgaggucgugaguucgauccucacauuaccca .<<<.....<<...........>>..<............>......<..<<.......>>..>...>>>..... .(.(.....((...........))(.(............).)....(..((.......))..)...).)..... Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine, small subunit; E-site tRNA 6ole S2 1714 3.1 RF01960,RF01959,RF00177 URS0000EEAD2D_9606 31160784 0003735 0005840 9606 uaccugguugauccugccaguagcaunugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuauggunccuunggucgcucgcuccucucccacuuggauaacugugguanuucuagngcuaauanaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgccccccguggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcnaauuacccacucccgacccgggganguagugangaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugagucnacuuuaaauccuuccgcgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauancguauauuaaaguugcugcaguunaaaagcucguaguungaucuugggagcgggcguccccgcccucucggccggggcccgaagcauuuacuuugaaaaaanuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagancgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccacnaggaguggagccugcggcuuaauuugacncaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggcnguucuuaguugguggagcgauuugucugguuaauucngauaacgaacgagacucuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauunagucccugcccuuuguacacaccgnccgucgnuacuaccgauuggaugguuuagugaggcccucggaucggcccggagcgcugagaagacggucgaacuugncuaucuagaggaaguaaaagucgnancaagguuucnguaggugnnccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<.........<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<......<<....<<<<...................<<.....<<.<<.......>>.>>......>>.........<<<<......................>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<<......>>>>>>>>..>.>>>...>>....>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>......>>.>......<.....<<.<........>.>>.......>.......<<..<...........>..>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<.......................<<................>>....<<<<<.<.......<<...<.......>.<<<<.......>>>>...>>......>.>>>..>>.........<.<<.<<..<<<...............>>>..>>.>>.>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>.>.>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<......<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<.<<<<<.....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<.......>>>>.>>>>.....>>>>..>>>>..>.....<<<<<.....>>>>>........>>>.....>>.>>>.....>>>>>>>.......>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<...<.<<<<<..........>>>>>>....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<..<<<<.<<<..<<<<.<<...<<<<<.......>>>>>...>>.>>>>..>>>.>>>>.>>....>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... 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Human ribosome nascent chain complex (CDH1-RNC) stalled by a drug-like molecule with AP and PE tRNAs; 18S ribosomal RNA 6ole D 157 3.1 RF00002 URS0000005270_9606 31160784 0003735 0005840 9606 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>.............>>>..)...>>>....<<....>><<<<<<<<.......>>>>>>>>..................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))(((((((.........)))))))..................... Human ribosome nascent chain complex (CDH1-RNC) stalled by a drug-like molecule with AP and PE tRNAs; 5.8S ribosomal RNA 6ole E 119 3.1 RF00001 URS00000F9D45_9606 31160784 0003735 0005840 9606 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>. (((((((((....((((((((.....((..((...(....)...))....))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))). Human ribosome nascent chain complex (CDH1-RNC) stalled by a drug-like molecule with AP and PE tRNAs; 5S ribosomal RNA 6ole t 3607 3.1 RF02540,RF02543 URS0000EEAD2F_9606 31160784 0003735 0005840 9606 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Human ribosome nascent chain complex (CDH1-RNC) stalled by a drug-like molecule with AP and PE tRNAs; 28S ribosomal RNA 6ole u 76 3.1 RF00005 URS0000EEAD11_9606 31160784 0030533 0006412 9606 gcccggauagcucagucgguagagcaggggauuccguauccccguguccuugguucgauuccgaguccgggcacca ..<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>...... ...((((..((.(........).))..((((.......))))......((.((.......)).))))))....... Human ribosome nascent chain complex (CDH1-RNC) stalled by a drug-like molecule with AP and PE tRNAs; AP RNA 6ole v 76 3.1 RF00005 URS0000EEAD31_9606 31160784 0030533 0006412 9606 ugcccgguagccccgaagguagagcaggggauuccgaauccccguguccuugguucgauuccgaguccgggcacca ..<<<<<..<<............>>.<<<<<<.....>>>>>>......<<<.........>.>>.>>>>>..... ...((((..((....[.......)).(((((.......)))))......((((.....].)).)).))))...... Human ribosome nascent chain complex (CDH1-RNC) stalled by a drug-like molecule with AP and PE tRNAs; PE RNA 6ole w 10 3.1 31160784 9606 uuacggcggu .......... .......... Human ribosome nascent chain complex (CDH1-RNC) stalled by a drug-like molecule with AP and PE tRNAs; mRNA 6olf S2 1714 3.9 RF01960,RF01959,RF00177 URS0000EEAD2D_9606 31160784 0003735 0005840 9606 uaccugguugauccugccaguagcaunugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuauggunccuunggucgcucgcuccucucccacuuggauaacugugguanuucuagngcuaauanaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgccccccguggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcnaauuacccacucccgacccgggganguagugangaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugagucnacuuuaaauccuuccgcgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauancguauauuaaaguugcugcaguunaaaagcucguaguungaucuugggagcgggcguccccgcccucucggccggggcccgaagcauuuacuuugaaaaaanuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagancgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccacnaggaguggagccugcggcuuaauuugacncaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggcnguucuuaguugguggagcgauuugucugguuaauucngauaacgaacgagacucuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauunagucccugcccuuuguacacaccgnccgucgnuacuaccgauuggaugguuuagugaggcccucggaucggcccggagcgcugagaagacggucgaacuugncuaucuagaggaaguaaaagucgnancaagguuucnguaggugnnccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<....<<....<<<<<..................<<.....<<.<<.......>>.>>......>>.........<<<<.......<.....>........>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<<......>>>>>>>>.>>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>...<<....>>.....>>>>>>.........<<<....<<<.....>>>..>>>..>...>>.>.....<<<<...<<..<......>..>>....>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<.......................<<................>>....<<<<<.<.......<<...<.......>.<<<<.......>>>>...>>......>.>>>..>>.........<.<<.<<<<<<<...............>>>>>>>.>>.>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>.>.>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<.....<<<.<<<<......>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<.......>>>>.>>>>.....>>>>..>>>>..>.....<<<<<.....>>>>>........>>>.....>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<.....<..<<<<.<<<..<<<<.<<...<<<<<.......>>>>>...>>.>>>>..>>>.>>>>.>.....>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...[.[[..(.(((..]].](((.((((((...(.((..(......(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..(.....(((.....((.............((.....((.(((.....))).))......))......))..(((......................))).((..(((((...(......)..)))))......)).(.((((.((((......)))))))))...)))....)).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).........(((....(((.]...)))..)))..)...)).).....((.....(...((....))...)......).)....(.(...(...........)...)......)..((((([[....(.((((......(..]])........))))))))))..)))))).)))..[......(.([[...(.(.((...(((..(.......................((................))....(((((.(.......((...(.......)..(((.......)))....))......).)))..)).........(.((......((...............))......)).)....)....((((((...(....(((..((..((((((((...((........))......))))))))..)).......((....))...)).)..)...)).)))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.((((......)))))))))).)..)))...((..]]))...))...].))))).).(((......((((....))))....)))...))).)((((..(((((((..((..(((((..(((.((((((......((........))..........(((((.(....((((((....(..((.((..........)).))....)))))))...((.(((...(.(((((.....(((.(((((....)))..(.((......)))...)).)))....(((.......((((..((((((((((((.......)))).)))).....))))..))))........(((((.....)))))........))).....)).))).....).))))).....).)))))...)).)))).))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....((((((((.......))))))))......))...))))))).)).))..(.(..((.(..((((.((........(..(.(((..((((.((...((.(.........).))...)).))))..))).).)........)).))))...).))...)..)..(((((((((....)))))))))}........ Human ribosome nascent chain complex (CDH1-RNC) stalled by a drug-like molecule with AA and PE tRNAs; 18S ribosomal RNA 6olf D 157 3.9 RF00002 URS0000005270_9606 31160784 0003735 0005840 9606 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>.............>>>..)...>>>....<<....>><<<<<<<<.......>>>>>>>>..................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))(((((((.........)))))))..................... Human ribosome nascent chain complex (CDH1-RNC) stalled by a drug-like molecule with AA and PE tRNAs; 5.8S ribosomal RNA 6olf E 119 3.9 RF00001 URS000064027A_9606 31160784 0003735 0005840 9606 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>. (((((((((....((((((((.....((..((...(....)...))....))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))). Human ribosome nascent chain complex (CDH1-RNC) stalled by a drug-like molecule with AA and PE tRNAs; 5S ribosomal RNA 6olf t 3607 3.9 RF02540,RF02543 URS0000EEAD2F_9606 31160784 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgcgcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcggcccggcggaucuuucccgcccccggggucggcgggggaccgucccccggaccggcgaccggccgccgccgggcgcauuuccaggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucggggcccccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcgcucuccccccugggggggccgggccaccccucccacggcgcgaccgcucucccagggggcggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccggggggccacgcgcgcgucccccgaagggggggacggcggagagcgcacggggucggcggcgacgucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgaggggcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcccacgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcgucgagaguggacgggagcggcggcccggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcuggcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacguuuuuucacugacccggugaggcgggggggcgagcccgaggggcucucgcuucuggcgccaagcgcccgcccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucgccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccgguccccgccggggguccggugcggagugcccuucguccugggaaacggggcgcggccggaaaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuuguc .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..[[[......<.....<<<<<.<<....>>.>>>>>.......>......<.<<..<<.....<...<<...<....<<<<........<.<........>.>..................................>>>>.>.>>...>....>>..>>.>.......<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<..........<<.<..<<<....<<.<..<..<.........<<...<<......<<<<<.<<<..<<<<<<<<<.>>>..>>>>>>>>>>>>>>.>>...>>..........>..>..>.>>....>>>..>.>>.....<<<<<<<<.<<<<<<<<<<.<<<........<...<<.<<.<...<..<<<<<<<...>>>>>>>..>.....>>>.>>..>...........>>>...>>>>>>>>>>...........................<<<<<<..>>>>>>....<<....<..<<...<....<.<<<<<...<<...>>..<<<<<<.<<<<....>>>>.>>>>>>.>>>>>.>....>....>>....>....>>..........<<<<<<....>>>>>>....................>>>.>>>>>....>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<......>>>>>>>..<<<<<..<<<...<..............>...>>>...>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<..<<........>>.>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<........<<<.<<<<<<<<<...<<<....<<<....<<<...<.<<<.........>>>.>.>>>....>>>..>.>>...>>>>>>>...<<<<<<<<<.........>>>>>>>>.>..>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<......<..........<<<.<<<<<<<<<......<.<<<<<.<<<....<.........>....>>>.........<<......>>...>>>>>.>..>>>>>>>>>>>>..........))).>....>>>>>..>>>...>>>>>>><<<<<<.<.................................................>.>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<<<<<...>>>>>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<..<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..{{{..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<...............<<<<<.....<..>......>>>>><<.<<<<<<<<<<<.>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<....<<<<<....>>>>.>...>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>.....[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<<.<<<<<<<<<..>>>>>>>>>...<<<<<.....<<<<....................................<<<<<<<......>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..(((..>>>>>>.)))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>........<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>.....<<<<<<<....>>>.>>>>....}}..}}}.]]]]......<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<.}}}..>>>>..>>.>>...>>>>...>>>><<<<....<<<<<...........>>>>>....>>>>.>>>...>.>>>>>>......<<<<<..<<..<<<...................<.<<<<....>>>>.>..................<<<..<<<<.....<.<.<<<<<<<......>>>>>>>.>>....>>>>..>>>..............>>>...>>.>>>>>.<<<<<.<.............>.....<.<<<<<<<.<<.....<<<<....<<<<<......>>>>>...>>>>....>>....>>>>.>>>.>...>>>>>... .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.....(.....((((.(.(.....).))))).......)......(.(...((.....(...(.........((((..........(........).........(...)...(........).........))))....)...)....))...).)..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.(.....(..((.(.(.((....((.(..(..(.....(..(((..(((.(....(((((.(((..(((((((((.)))..)))))))))))))))))..))).)....)...)..)..).))....))..)).))..)...(((((((.((((.(((((.(((........((.(((.((........((((((((.)))))))).........)).)))))...........)))...))))).)))).........................(.((((((()))))))...(.(.......((...(.(..(.(((((...((...))..((((((.((((....)))).)))))).))))).)...))....)).........))...........(((((....)))))...........).........))).))))....))))...)))))))).[((((........))))((((((....(((((((((((((..(((..(((((........))))..)..)))...((....))...(((((((......)))))))..(..((...((...(.(...........))...))....))..).((((..(((.((((......)))))))..)).))....)))))))))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((........(((.((((((((....(((....((...(.((((..((.(...........).)))))).)...))..)).)....))))))....((((((((.(......)))))))))....))))))))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.(.((((((((.......(((((.(((...(...........)...))).........(........)...)))))...)))))))).))))..........]]].)....))))))))))...)))))))((((((.(.................................................).))))))....)))))).(.((((((((.(.(.....((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((..(((((((....(.....)..))))))....[[(((.((...((....(((....)))..........((.((((((.((...)).))))))))......))....))...(.(((........))).)]]((((....(((((...(((((((....)))))))..(.((....))....(...((((.(...((.((((((((((((((((((((..{{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))).))(...)....).))))...)).........)).))).)))).))).))).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((.)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((....(((.....((((....)))).....))).))))..)))))(((((.........)))))........((.(......).(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.(((((((((.(((((((((())))))))))...(((((.....((((..(.......(...)......)..............(((((((......)))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))(.((...(((((((.(.((((((.......))))))...).((...[[[))....)))))))...(((.(((((....{..)))).)))).(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((.(...((((((...((.......))...))))))....).).)........(.((.((((((..(.(.(.(((......))).)...).).(((.(.....).))).....)))))..)...))..).....(((((((....))).))))..>.))..))).))))).....((((((....(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}}.)))))..)).))...))))...)))).(((.....(((.............))).....)))..))).....))))))......(((((..((..((......(................((......))................)....(((..((((.......(.((((.((......).))))))......))))..)))...............))...)).))))).(((((.(..(.......)..).....(.(((((((..(.....((((.(..(((((......)))))..)))))....).....)))).))).)...)))))... Human ribosome nascent chain complex (CDH1-RNC) stalled by a drug-like molecule with AA and PE tRNAs; 28S ribosomal RNA 6olf v 76 3.9 RF00005 URS0000EEAD31_9606 31160784 0030533 0006412 9606 ugcccgguagccccgaagguagagcaggggauuccgaauccccguguccuugguucgauuccgaguccgggcacca ..<<<<<..<<............>>.<<<<<<.....>>>>>>......<.<.........>..>.>>>>>..... ...((((..(.(...[.......)).(((((.......))))).......(((.(..)].)).)..))))...... Human ribosome nascent chain complex (CDH1-RNC) stalled by a drug-like molecule with AA and PE tRNAs; PE tRNA 6olf w 10 3.9 31160784 9606 uuacggcggu .......... .......... Human ribosome nascent chain complex (CDH1-RNC) stalled by a drug-like molecule with AA and PE tRNAs; mRNA 6olf u 76 3.9 RF00005 URS0000EEAD11_9606 31160784 0030533 0006412 9606 gcccggauagcucagucgguagagcaggggauuccguauccccguguccuugguucgauuccgaguccgggcacca ..<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>...... ..(.(((..((.(........).))..((((.......))))......(((((.......)))))))).)...... Human ribosome nascent chain complex (CDH1-RNC) stalled by a drug-like molecule with AA and PE tRNAs; AA tRNA 6olg A3 157 3.4 RF00002 URS0000005270_9606 31160784 0003735 0005840 9606 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>.............>>>..)...>>>....<<....>><<<<<<<<.......>>>>>>>>..................... .........................................((((((.[[....[)))...].(.(((......]].............)))..)...)))....((....))(((((((.........)))))))..................... Human ribosome nascent chain complex stalled by a drug-like small molecule (CDH1_RNC with PP tRNA); 5.8S ribosomal RNA 6olg A4 119 3.4 RF00001 URS000064027A_9606 31160784 0003735 0005840 9606 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcu .<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>.. .((((((((....((((((((.....((..((...(....)...))....))....)))))).))((((((......((.((..((....)).)).)).....)))))))))))))).. Human ribosome nascent chain complex stalled by a drug-like small molecule (CDH1_RNC with PP tRNA); 5S ribosomal RNA 6olg A2 3612 3.4 RF02540,RF02543 URS0000E60BB6_9606 31160784 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgcgcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcggcccggcggaucuuucccgcccccggggucggcgggggaccgucccccggaccggcgaccggccgccgccgggcgcauuuccaggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucggggcccccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcgcucuccccccugggggggccgggccaccccucccacggcgcgaccgcucucccagggggcggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccggggggccacgcgcgcgucccgggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgaggggcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcccacgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggccuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcuggcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacaugagagguguagaauaagugggaggcccgggccgccggugaaauaccacuacucugaucguuuuuucacugacccggugaggcgggggggcgagcccgaggggcucucgcuucuggcgccaagcgcccgcccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucgccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccgguccgggguccggugcggagugcccuucguccugggaaacggggcgcggccggaaaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuuguc 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.........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.....(.....((((.(.(.....).))))).......)......(.(...((.(...(.(.(.........(((.(.(.......(........).........(...)....................).))))....)..))...)))...).)..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.......(..((.(...((....((.((.(..(.....(..(((.((((.(....(((((.(((..(((((((((.)))..))))))))))))))))).)))).)....)...)..)).).))....))...).))..)...(((((((.(.((((((((.(((........((.(((.((.(...((.((((((((.))))))))).).....))).)))))...........)))...)))))))).)....................(((..(.((((((()))))))....(((..(((.((...(....(.((((....((...)).(((((((.((((....)))).))))))).))))..)...)....))....))).))).........((((()))))..........))))......))).)))).....)))...)))))))).[((((........))))((((((....(((((((((((((..(((..((((..........)))..)..)))...(......)...(((((((......)))))))..(((((...((...(..............)...))....))))).(((((((((.((((......))))))))))).))....)))))))))))))..((.(...((((((.....(((((((((..((.(...(((((((....)))))))...)[.))....((..((.((........)))).)).....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((........(((.((((((((....(((....(((..(.(((..(.(((..(.....)..)))).))).)..)))..)).)....))))))....((((((((.(......)))))))))....))))))))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.(.((((((((.......(((((.(((...................))).....(...(........).).)))))...)))))))).))))..........]]].)....))))))))))...)))))))((((((.(.......).))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((..(((((((....(.....)..))))))....[[(((.((...((....(((....)))..........((.((((((.((...)).))))))))......))....))...(.(((........))).)]]((((....(((((...((.((((....)))).))..((((....)))...(...((((.(...(((((((((((((((((((((((..{{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....).))))...)).........)).))).)))).))).))).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((.)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.....((.....((((....)))).....))..))))..))))).((((.........))).)........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.(((((((((.(((((.((((((.(((........[..(((((..((((()))))..........].)))))..))).)).)))).)))))...(((((.....((((..(..(.(.((...))..).))..............(((((((......)))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(.(.(((......))).)...).)..((.(.....).))......)))))..)...))).).....(((((((....))).))))....))..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}}.)))))..)).))...))))...)))).((((...((((.............))))...))))..)))...).))))))......(((((..(...((.(.....................(()).....................(((..((((..(..(.(.(((((((......)))))))).).)..))))..)))..............)))....).))))).(((((.(..(.......)..).....(.(((((((.((.....((((.(..(((((......)))))..)))))....))....)))).))).)...)))))... Human ribosome nascent chain complex stalled by a drug-like small molecule (CDH1_RNC with PP tRNA); 28S ribosomal RNA 6olg B1 1708 3.4 RF01960,RF01959,RF00177 URS0000E60B9C_9606 31160784 0003735 0005840 9606 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucagaucaaaaccaacccgggcuuuggugacucuagauaaccucgggccgaucgcacgccccccguggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcggccccuugccucucgcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgacccccgagcgguaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccguggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<...[[[[>>>>>[[[.((((((.....{{.........[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[......{{....[[[[[....<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<<<....>>>>>>...>>>>[[..(((((.....<<<<<<<<<<<.>>....<......>..)))))......]]...<<<<.<<<<......>>>>>>>>.]].]]]...}}....]]].<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>......}}.......<<<<<<<<<.<<<....>>>..>>>>>.>>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..)))))).]]]............{{.......{{...[[[.......<<<.....>>>....<.<..<....>>.>...<<<<<<.<.......<<...<.......>.<<<<.......>>>>...>>......>.>>>..>>>........[....(((((((.....>>>>>>>>>.)))))))....]..........<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<........>>>>>>>>>.>..>>>...<<..}}>>...>>.....>>>.....<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<.......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<......>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<..<<..<......>..>>>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.....>.>>>>>....>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<...<.<<<<<..........>>>>>>....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<.<<<<<..>>>>>...>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((...(....((....((..........))...)){)........((.......(((.(.(..(.....(((......((.....((..((.....))..))......))...........((...((((((....))))))...))......(((((......[[[[[[[.((.))....(......)..))))).........(.((((.((((......)))))))))...)))....)).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))..((.(((..........))).)).(.((....)).)...)))))).).......(((...(.((.}...))..))))..)...)).).....(.(((((((.(((....)))..))))).)).)......((..(...........)..)).........((((([.....(.((((.....((...])).......))))))))))..)))))).))).........(.({{...(.(.((...(((..(.....((.....)).....(.(..((..))).)....(.(((.(.......((..((.......)).(((.......)))....))......).)))....)...........(.(.((.((......]]]]]]]..)).)).)..)......)....((...(...(...((((..((..((((((((...((........))......))))))))..)).......((....))...))))..)...)....)..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..(.((((((.(((........))))))))).)..)))...((..}}))...)).....))))).).(((......((((....))))....)))...]]].](.(((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((........((.(((........))).))......)))))....(.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((...(...((((...(((..((..(......)..)))))...))))..).....(((((.....)))))........)))....))).))).....).))))......).)))))...)).)))).))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....((((((((.......))))))))......))...))))))))))..)..(.(..((.(..((((.((..(..(((((((.(((..((((.((...(((((.(((((())))))...)))))...)).))))..))).))))))).)..)).))))...).))...)..)..(((((((((....)))))))))>........ Human ribosome nascent chain complex stalled by a drug-like small molecule (CDH1_RNC with PP tRNA); 18S ribosomal RNA 6olg Bv 76 3.4 RF00005 URS00005AA258_9606 31160784 0030533 0006412 9606 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>><<<<<<<.....>>>>>>.>...<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).(((((.......))))).....((.((..]....)).))))))))).... Human ribosome nascent chain complex stalled by a drug-like small molecule (CDH1_RNC with PP tRNA); tRNA 6olg Bx 16 3.4 URS0000B21DCD_5691 31160784 9606 uuuuuuuuuuuuuuuu ................ ................ Human ribosome nascent chain complex stalled by a drug-like small molecule (CDH1_RNC with PP tRNA); mRNA 6oli S2 1714 3.5 RF01960,RF01959,RF00177 URS0000EEAD2D_9606 31160784 0003735 0005840 9606 uaccugguugauccugccaguagcaunugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuauggunccuunggucgcucgcuccucucccacuuggauaacugugguanuucuagngcuaauanaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgccccccguggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcnaauuacccacucccgacccgggganguagugangaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugagucnacuuuaaauccuuccgcgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauancguauauuaaaguugcugcaguunaaaagcucguaguungaucuugggagcgggcguccccgcccucucggccggggcccgaagcauuuacuuugaaaaaanuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagancgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccacnaggaguggagccugcggcuuaauuugacncaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggcnguucuuaguugguggagcgauuugucugguuaauucngauaacgaacgagacucuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauunagucccugcccuuuguacacaccgnccgucgnuacuaccgauuggaugguuuagugaggcccucggaucggcccggagcgcugagaagacggucgaacuugncuaucuagaggaaguaaaagucgnancaagguuucnguaggugnnccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<....<<....<<<<<..................<<.....<<.<<<.....>>>.>>......>>.........<<<<......................>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<<......>>>>>>>>.>>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>......<.....<<............>>.......>.......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<.......................<<................>>....<<<<<.<.......<<...<.......>.<<<<.......>>>>...>>......>.>>>..>>.........<.<<.<<..<<<...............>>>..>>.>>.>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>.>.>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<......<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<.<<<<<.....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<.......>>>>.>>>>.....>>>>..>>>>..>.....<<<<<.....>>>>>........>>>.....>>.>>>.....>>>>>>>.......>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<..<<<<.<<<..<<<<.<<...<<<<<.......>>>>>...>>.>>>>..>>>.>>>>.>>....>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..((....(((.....((.............((.....((.(((.....))).))......))......)).((((......................))))((..(((((...(......)..)))))......)).(.((((.((((......)))))))))...)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).......(((...((((.]...))).))))..)...)).).....(......(...(.....)....)........)....(.((..(...........)..))......)..((((([[....(.((((.....((..]])).......))))))))))..)))))).)))..[......(.([[...(.(.((...(((..(.......................((................))....(((((.(.......((..((.......)).(((.......)))....))......).)))..)).........(.((.(.(..((...............))..).).)).)....)....(((.((...(...(.((..((..((((((((...((........))......))))))))..)).......((....))...)).)..)...))..))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.((((......)))))))))).)..)))...((..]]))...))...].))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.((..........)).))....).)))))...((.(((...(.(((((.....(((.(((((....)))..(.((......)))...)).)))....(((...(...((((..((((((((((((.......)))).)))).....))))..))))..).....(((((.....)))))........))).....)).))).....).))))).....).)))))...)).)))).))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((...........(.(((..((((.((...((.(.........).))...)).))))..))).)..........)).))))...).))...)..)..(((((((((....)))))))))}........ Structure of human ribosome nascent chain complex selectively stalled by a drug-like small molecule (USO1-RNC); 18S ribosomal RNA 6oli D 157 3.5 RF00002 URS0000005270_9606 31160784 0003735 0005840 9606 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>.............>>>..)...>>>....<<....>><<<<<<<<.......>>>>>>>>..................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))(((((((.........)))))))..................... Structure of human ribosome nascent chain complex selectively stalled by a drug-like small molecule (USO1-RNC); 5.8S ribosomal RNA 6oli E 119 3.5 RF00001 URS00000F9D45_9606 31160784 0003735 0005840 9606 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>. (((((((((....((((((((.....((..((...(....)...))....))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))). Structure of human ribosome nascent chain complex selectively stalled by a drug-like small molecule (USO1-RNC); 5S ribosomal RNA 6oli t 3607 3.5 RF02540,RF02543 URS0000EEAD2F_9606 31160784 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgcgcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcggcccggcggaucuuucccgcccccggggucggcgggggaccgucccccggaccggcgaccggccgccgccgggcgcauuuccaggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucggggcccccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcgcucuccccccugggggggccgggccaccccucccacggcgcgaccgcucucccagggggcggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccggggggccacgcgcgcgucccccgaagggggggacggcggagagcgcacggggucggcggcgacgucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgaggggcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcccacgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcgucgagaguggacgggagcggcggcccggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcuggcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacguuuuuucacugacccggugaggcgggggggcgagcccgaggggcucucgcuucuggcgccaagcgcccgcccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucgccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccgguccccgccggggguccggugcggagugcccuucguccugggaaacggggcgcggccggaaaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuuguc .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..[[[..<...<.....<<<<.<.........>>>>>.......>..>...<.<<..<<.....<.<......<....<<<<........<.<........>.>..................................>>>>.>.....>>....>>..>>.>.......<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<.......<..<<.<..<<<....<<.<..<..<.........<<...<<.......<<<<.<<<..<<<<<<<<<.>>>..>>>>>>>>>>>>>..>>...>>..........>..>..>.>>....>>>..>.>>..>..<<<<<<<<.<<<<<<<<<<.<<<........<.<.<<.<<.<......<<<<<<<<.>>>>>>>>........>>>.>>>.>...........>>>...>>>>>>>>>>...........................<<<<<<..>>>>>>....<<....<..<<...<....<.<<<<<...<<...>>..<<<<<<.<<<<....>>>>.>>>>>>.>>>>>.>....>....>>....>....>>..........<<<<<<....>>>>>>....................>>>.>>>>>....>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<<....>>>>>>>>..<<<<<..<<<...<.....[........>...>>>...>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<........<<<.<<<<<<<<<...<<<....<<<..<.<<<..<<<<<<.<.....>.>>>>>>>>>.>..>>>..>.>>...>>>>>>>....<<<<<<<<.........>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<.................].....<.....>...................>.>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<<<<<...>>>>>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<..<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..{{{..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<...............>>>>><<.<<<<<<<<<<<.>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<....<<<<<....>>>>.>...>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<<.<<<<<<<<<..>>>>>>>>>...<<<<<.....<<<<..........<...>.....................<<<<<<<......>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>>.<<<....>>>.>>)))]......((((((..(((..>>>>>>.)))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]].....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<.}}}..>>>>..>>.>>...>>>>...>>>><<<<....<<<<<...........>>>>>....>>>>.>>>...>.>>>>>>......<<<<<<.<<..<<<..<................<.<<<<....>>>>.>..................<<<..<<<<.......<.<<<<<<<......>>>>>>>.>.....>>>>..>>>..........>...>>>...>>>>>>>>.<<<<<.<.............>.....<.<<<<<<<.<<.....<<<<....<<<<<......>>>>>...>>>>....>>....>>>>.>>>.>...>>>>>... .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.....(.....((((.(.(.....).))))).......)......(.(...((.....(...(.........((((..........(........).........(...)......................))))....)...)....))...).)..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((....(..((.(.(.((....((.(..(..(.....(..(((..(((.(....(((((.(((..(((((((.(.).)..))))))))))))))))).).)).)....)...)..)..).))....))..)).))..)...(((((((.((((.(((((.(((........(((.((.((........((((((((.)))))))).........)).)))))...........)))...))))).))))...........................((((((..))))))...(.....(((.((...(.(..(.((((....((...))..((((((.((((....)))).))))))..)))).)...))....))....)))...)...........(((((....))))).....................))).))))...)))))...)))))))).[((((........))))((((((....(((((((((((((..(((..(((((........))))..)..)))...((....))...((((((((....))))))))..(((((...((...(...........[..)...))....))))).(((((((((.((((......))))))))))).))....)))))))))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((........(((.((((((((....(((....(((..(.((((..((.(..(.....)..).)))))).)..)))..)).)....))))))....((((((((.(......)))))))))....))))))))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.(.((((((((.......(((((.(((...................))).........(........)...)))))...)))))))).))))..........]]].)....))))))))))...)))))))((((((.(...........].....................................).))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((..(((((((....(.....)..))))))....[[(((.((...((....(((....)))..........((.(((((((((...)))))))))))......))....))...(.(((........))).)]]((((....(((((...(((((((....)))))))..((((....)))...(...((((.(...(((((((((((((((((((((((..{{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....).))))...)).........)).))).)))).))).))).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((.)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((....(((.....((((....)))).....))).))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.(((((((((.(((((((((())))))))))...(((((.....((((..(..(....(...).....))..............(((((((......)))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(.(.(((......))).)...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a.))..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}}.)))))..)).))...))))...)))).(((....((((.............))))....)))..)))...).))))))......(((((..(...((......(................(((....)))................)....(((...(((.....(.(.(((((((......)))))))).)....)))...)))...............))....).))))).(((((.(..(.......)..).....(.(((((((.((.....((((.(..(((((......)))))..)))))....))....)))).))).)...)))))... Structure of human ribosome nascent chain complex selectively stalled by a drug-like small molecule (USO1-RNC); 28S ribosomal RNA 6oli u 76 3.5 RF00005 URS0000EEAD11_9606 31160784 0030533 0006412 9606 gcccggauagcucagucgguagagcaggggauuccguauccccguguccuugguucgauuccgaguccgggcacca ..<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>...... ...((((..((............))..((((.......))))......((.((.......)).))))))....... Structure of human ribosome nascent chain complex selectively stalled by a drug-like small molecule (USO1-RNC); tRNA 6oli v 76 3.5 RF00005 URS0000EEAD31_9606 31160784 0030533 0006412 9606 ugcccgguagccccgaagguagagcaggggauuccgaauccccguguccuugguucgauuccgaguccgggcacca ...<<<<..<<............>>.<<<<<<.....>>>>>>......<<<.........>.>>.>>>>...... ...((((..((....[.......)).(((((.......))))).......(((.(..)].)).)..))))...... Structure of human ribosome nascent chain complex selectively stalled by a drug-like small molecule (USO1-RNC); tRNA 6oli w 10 3.5 31160784 9606 uuacggcggu .......... .......... Structure of human ribosome nascent chain complex selectively stalled by a drug-like small molecule (USO1-RNC); mRNA 6olz A3 157 3.9 RF00002 URS0000005270_9606 31160784 0003735 0005840 9606 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcuu .........................................<<<<<<<<<....>>>>.....<.<<<......>>.............>>>..>...>>>....<<....>><<<<<<<<.......>>>>>>>>..................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))(((((((.........)))))))..................... Human ribosome nascent chain complex (PCSK9-RNC) stalled by a drug-like molecule with PP tRNA; 5.8S ribosomal RNA 6olz A4 119 3.9 RF00001 URS000064027A_9606 31160784 0003735 0005840 9606 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<......<.<<..<<....>>.>>.>.....>>>>>>>>>>>>>>>>. (((((((((....((((((((.....((..((...(....)...))....))....)))))).)).((.((......((.((..((....)).)).)).....)).)).))))))))). Human ribosome nascent chain complex (PCSK9-RNC) stalled by a drug-like molecule with PP tRNA; 5S ribosomal RNA 6olz A2 3643 3.9 RF02540,RF02543 URS0000EEAD14_9606 31160784 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgcgcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcggcccggcggaucuuucccgcccccggggucggcgggggaccgucccccggaccggcgaccggccgccgccgggcgcauuuccaggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucggggcccccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggaagcgagacgucgccgcgcucuccccccugggggggccgggccaccccucccacggcgcgaccgcucucccagggggcggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccggggggccacgcgcgcgucccgggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgaggggcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcccacgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcgucgagaguggacgggagcggcggcccgcccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcuggcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacaugauagaauaagugggaggcccgggccgccggugaaauaccacuacucugaucguuuuuucacugacccggugaggcgggggggcgagcccgaggggcucucgcuucuggcgccaagcgcccgcccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucgccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccgguccgggguccggugcggagugcccuucguccugggaaacggggcgcggccggaaaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuuguc .........................<<<<<<<....<......>.....>>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..[[[..<...<.....<<<<<.<<....>>.>>>>>.......>..>...<.<<..<<.....<....<...<....<<<<........<.<........>.>..................................>>>>.>.>....>....>>..>>.>.......<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<......>>>..................................<<<<<<<<..<<<..........<<.<.<<<<......<<..<.<<.........<<...<<.<....<<<<<.<<<..<<<<<<<<<.>>>..>>>>>>>>>>>>>>>>>...>>..........>.>>..>.>.....>>>>.>.>>.....<<<<<<<..<<<<<<<<<..<<<........<<.<<<.<<.<......<<<<<<<...>>>>>>>........>>>.>>>>>...........>>>....>>>>>>>>>...................<<<....<<<<<<..>>>>>>....<<<.<<<..<<...<.<..<.<<<<<...<<...>>.<<<<<<<.<<<<....>>>>.>>>>>>>>>>>>.>...>>....>>....>>>.>>>........<<<<<.>.>>>>..........>>>.......>>.>>>>>....>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<......>>>>>>>..<<<<<..<<<...<.....[[...[...>...>>>...>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>(><<.<<<<<<<........<<<.<<<<<<<<<...<<<....<<<....<<<...<<<<<.........>>>>>.>>>....>>>..>.>>...>>>>>>>....<<<<<<<<.........>>>>>>>>....>>>>>>>>>>>>..>>).<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<.....................>>.........<........>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<............]...]]...........................>.>>>>>>....>>>>>>.<<<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>.>>.....>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<<<<<...>>>>>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<..<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..{{{..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<...............<<<<<...............>>>>><<.<<<<<<<<<<<.>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<..<<<....<<<<<....>>>>.>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<<.<<<<<<<<<.<<.........<<<<<..<<<<..>>>>............>>>>>......>>..>>>>>>>>>...<<<<<.....<<<<........<<<...>>>...................<<<<<<<......>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..(((..>>>>>>.)))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>........<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>.....<<<<<<<....>>>.>>>>....}}..}}}.]]]]].....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<.}}}..>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.....<<<<<<<.<<..<<<...................<.<<<>>>.>..................<<<..<<<<.....<<<.<<<<<<<......>>>>>>>>>>....>>>>..>>>..............>>>...>>>>>>>>><<<<<.<.............>.....<.<<<<<<<.<<.....<<<<.<..<<<<<......>>>>>..>>>>>....>>....>>>>.>>>.>...>>>>>... .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.....(.....((((.(.(....)..))))).......)......(.(...((.(...(...(.........((((..........(........).........(...)......................))))....)...)...)))...).)..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))...............((((....))))..................................((((((((..(((.......(..((.(...((.....((...(..(.....(..(((..(((.(....(((((.(((..((((((((().))..))))))))))))))))).).)).)....)...)..)....))....))...).))..)...(((((((.((((.(((((.(((........(.((((.((.(......((((((((.))))))))........))).)))))...........)))...))))).))))...................(((..(.((((((()))))))...(.((...((.((...(.(..(.((((....((...)).(((((((.((((....)))).))))))).)))).)...))....))....))..))).........((((.).)))..........))))......))).)))).....)))...)))))))).[((((........))))((((((....(((((((((((((..(((...(((..........))).....)))...((....))...(((((((......)))))))..(((((...((...(......[.......)...).)...))))).(((((((((.((((......))))))))))).))....)))))))))))))...(.(...((((((.....(((((((((..((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))....))))))))).(.((.......))...)..))))))......).)...((((((....(.(((....))).).(.(((((((........(((.((((((((....(((....(((..(.(((..(.(((..(.....)..)))).))).)..)))..)).)....))))))....((((((((.(......)))))))))....))))))))))))..)...((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.(.((((((((.......(((((.(((...................))).....(..............).)))))...)))))))).))))..........]]].)....))))))))))...)))))))((((((.(................]......(.....)...............).))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((..(((((((....(.....)..))))))....[[(((.((...(.....(((....)))..........((.((((.(.((...)).).)))))).......)....))...(.(((........))).)]]((((....(((((...(((((((....)))))))..((((....)))...(...((((.(...(((((((((((((((((((((((..{{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....(((((((.......))))))))))).).))))))))))))(...)....).))))...)).........)).))).)))).))).))).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(........((((....(.[..).....)))).((.(((((((((((.)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.....((.....((((....)))).....))..))))..))))).((((.........))).).........(.(......).(((((.......)))))..).......)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.(((((((((.(((((.(.((.(......[..(((((..((((()))))..........].)))))......)..)).).)))))...(((((.....((((..(....(.((...))..)..)..............(((((((......)))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....)))))))....((.(((((....{..)))).)))..(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((.(...((((((...((.......))...))))))....).).)........((((.((((((..(.(.(.(((......))).)...).)..((.(.....).))......)))))..)...))).).....(((((((....))).))))..a.))..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}}.)))))..)).))...))))...)))).((((...((((.............))))...))))..)))...).))))))......(((((..(...((....................(..(())..)..................(((...(((.....(.(.(((((((......)))))))).)....)))...)))...............))....).))))).(((((.(..(.......)..).....(.(((((((..(.....((((.(..(((((......)))))..)))))....).....)))).))).)...)))))... Human ribosome nascent chain complex (PCSK9-RNC) stalled by a drug-like molecule with PP tRNA; 28S ribosomal RNA 6olz B1 1708 3.9 RF01960,RF01959,RF00177 URS0000E60B9C_9606 31160784 0003735 0005840 9606 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucagaucaaaaccaacccgggcuuuggugacucuagauaaccucgggccgaucgcacgccccccguggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcggccccuugccucucgcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgacccccgagcgguaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccguggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<...[[[.>>>>>[[[.((((((.....{{.........[[[.[[[...<....<.....<<..........>>....>.>.......{{........[[[......{{....[[[......<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<<<....>>>>>>...>>>>[[..(((((......<<<<<<<.<<.>>....<......>..)))))......]]...<<<<.<<<<......>>>>>>>>....]]]...}}....]]].<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>...<<....>>.....]]]]]].........<<<....<<<<...>>>>..>>>......}}.......<<<<<<<<<..<.......>..>>>>>.>>>>......<<..<...........>..>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..)))))).]]]............<<.......{{...[[[.[[....<<<.....>>>....<.<..<....>>.>....<<<<<.<.......<<...<.......>..<<<.......>>>....>>......>.>>>..>>...........[[.(((((((......>>>>>>>..))))))).]]......]]....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<..>>>>...>>.....>>>.....<<<......<<<<....>>>>....>>>...]]]..<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<..<<..<......>..>>>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>............<<<<<..........>>>>>...........>>>>>......<<<<<<.........>>>>>>.......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<.<<<<<..>>>>>...>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((...(....((....((..........))...)){)........((.......(((.(....(.....(((......((.....((..((.....))..))......))...........((...((((((....))))))...)).......((((......[[[[[[[.((.))....(......)..))))..........(.((((.((((......)))))))))...)))....)..).))).(((....(((.....((((((.........)))))).)))......)))...(((.((((....))))....)))))..((.((............)).)).(.((....)).)...)))))).).......(((...(.(..}....)..))))..)...)).).......((((.((.(.(....).)..)).)).))......................................((((([.....(.((((.....((...])).......))))))))))..)))))).))).........(.({{...(.(.((...(((..(.....((.....)).....(....((..))..)....(((((.(.......((..((.......)).(.(.......).)....))......).)))..).)...........(.(.((.((......]]]]]]]..)).)).)..)......)....(((..(.(.(...((((..(...((((((((...((........))......))))))))...).......((....))...))))..)..))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..(.((((((.((..........)))))))).)..)))...((..}}))...)).....))))).).(.(......((((....))))....).)...]]].](.((..(((((((..((..(((((..(((....(((......((........))..........(((((.(....(((((........((.(((........))).))......)))))...((.((......((((((....(((.(((((....)))..(.((......)))...)).)))....(((...(...((((...(((...(...(.....)..).)))...))))..).....(((((.....)))))........)))....))).)))........)))).....).)))))...)).)....))).(...((.(((........(.......((..((((....))))..))....).........))).))......(.....(((((..........))))).....)..)..))))).....((.(((((.......))))).))......))...))))))).))..)..(.(..((.(..((((.((....((((((.(.(((..((((.((...(((((.(((((..)))))...)))))...)).))))..))).).))))))...)).))))...).))...)..)..((((((.((....).)))))))>........ Human ribosome nascent chain complex (PCSK9-RNC) stalled by a drug-like molecule with PP tRNA; 18S ribosomal RNA 6olz Bv 76 3.9 RF00005 URS00005AA258_9606 31160784 0030533 0006412 9606 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((((.....)))))).....((.((..]....)).))))))))).... Human ribosome nascent chain complex (PCSK9-RNC) stalled by a drug-like molecule with PP tRNA; tRNA 6olz Bx 16 3.9 URS0000B21DCD_5691 31160784 9606 uuuuuuuuuuuuuuuu ................ ................ Human ribosome nascent chain complex (PCSK9-RNC) stalled by a drug-like molecule with PP tRNA; mRNA 6om0 S2 1714 3.1 RF01960,RF01959,RF00177 URS0000EEAD2D_9606 31160784 0003735 0005840 9606 uaccugguugauccugccaguagcaunugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuauggunccuunggucgcucgcuccucucccacuuggauaacugugguanuucuagngcuaauanaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgccccccguggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcnaauuacccacucccgacccgggganguagugangaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugagucnacuuuaaauccuuccgcgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauancguauauuaaaguugcugcaguunaaaagcucguaguungaucuugggagcgggcguccccgcccucucggccggggcccgaagcauuuacuuugaaaaaanuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagancgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccacnaggaguggagccugcggcuuaauuugacncaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggcnguucuuaguugguggagcgauuugucugguuaauucngauaacgaacgagacucuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauunagucccugcccuuuguacacaccgnccgucgnuacuaccgauuggaugguuuagugaggcccucggaucggcccggagcgcugagaagacggucgaacuugncuaucuagaggaaguaaaagucgnancaagguuucnguaggugnnccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<..<.....<<<............<<<<<..................<<.....<<.<<<.....>>>.>>......>>.........<<<<......................>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<<......>>>>>>>>.>>.>>>.........>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>>>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>..>>>..>...>>.>.....<<<....<..<........>..>......>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<.......................<<................>>........<.<.......<<...<.......>.<<<<.......>>>>...>>......>.>...............<.<<.<<..<<<...............>>>..>>.>>.>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>.>.>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<......<<<<<..<<<.<<<<<.......<<........>>..........<<<<<.<....<<<<<<.......<<.<<..........>>.>>.....>>>>>>...<<.<<<..<<.<<<<<<....<<<...<<......>>...<<<......>>>......>>>....<<<...<...<<<<..<<<<<<<<<<<<.......>>>>.>>>>.....>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.....>.>>>>>....>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>...........>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<..<<<<.<<<..<<<<.<<...<<<<<.......>>>>>...>>.>>>>..>>>.>>>>.>>....>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.....(....(((((...((.............((.....((.(((.....))).))......))......)).((((......................))))((..(((((...(......)..)))))......)).(.((((.((((......))))))))))).)))...)...).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).......(((...((((.]...))).))))..)...)).).....((...(.(..............)..)...).)....(.((..(...........)..))......)..((((([[....(.((((.....((..]])).......))))))))))..)))))).)))..[......(.([[...(.(.((...(((..(.......................((................))....(..((.(.......((..((.......)).(((.......)))....))......).))....).........(.((.(.(..(.................)..).).)).)....)....(((..(...(...(.((..(((.((((((((...((........))......)))))))).))).......((....))...)).)..)...)...))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.((((......)))))))))).)..)))...((..]]))...))...].))))).).(((......((((....))))....)))...]]].](((((.(((((((..(...(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.((..........)).))....).)))))...((.(((...(.(((((.....(((.(...(....)....(.((......)))....).)))....(((...(...((((..((((((((((((.......)))).)))).....))))..))))..).....(((((.....)))))........))).....)).))).....).))))).....).)))))...)).)))).))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....((.(((((.......))))).)).......)...)))))))))).))..(.(..((.(..((((.((........(..(.(((..((((.((...((.((.....)..).))...)).))))..))).).)........)).))))...).))...)..)..(((((((((....)))))))))}........ Human ribosome nascent chain complex (PCSK9-RNC) stalled by a drug-like molecule with AP and PE tRNAs; 18S ribosomal RNA 6om0 D 157 3.1 RF00002 URS0000005270_9606 31160784 0003735 0005840 9606 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>.............>>>..)...>>>....<<....>><<<<<<<<.......>>>>>>>>..................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))(((((((.........)))))))..................... Human ribosome nascent chain complex (PCSK9-RNC) stalled by a drug-like molecule with AP and PE tRNAs; 5.8S ribosomal RNA 6om0 E 119 3.1 RF00001 URS000064027A_9606 31160784 0003735 0005840 9606 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>. (((((((((....((((((((.....((..((...(....)...))....))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))). Human ribosome nascent chain complex (PCSK9-RNC) stalled by a drug-like molecule with AP and PE tRNAs; 5S ribosomal RNA 6om0 t 3607 3.1 RF02540,RF02543 URS0000EEAD2F_9606 31160784 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgcgcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcggcccggcggaucuuucccgcccccggggucggcgggggaccgucccccggaccggcgaccggccgccgccgggcgcauuuccaggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucggggcccccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcgcucuccccccugggggggccgggccaccccucccacggcgcgaccgcucucccagggggcggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccggggggccacgcgcgcgucccccgaagggggggacggcggagagcgcacggggucggcggcgacgucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgaggggcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcccacgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcgucgagaguggacgggagcggcggcccggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcuggcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacguuuuuucacugacccggugaggcgggggggcgagcccgaggggcucucgcuucuggcgccaagcgcccgcccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucgccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccgguccccgccggggguccggugcggagugcccuucguccugggaaacggggcgcggccggaaaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuuguc .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..[[[..<...<.....<<<<<..........>>>>>.......>..>...<.<<..<<.....<...<....<....<<<<........<.<........>.>..................................>>>>.>..>...>....>>..>>.>.......<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<.<.....<..<<.<..<<<....<<.<..<..<.........<<...<<.......<<<<.<<<..<<<<<<<<<.>>>..>>>>>>>>>>>>>..>>...>>..........>..>..>.>>....>>>..>.>>..>..<<<<<<<<.<<<<<<<<<<.<<<........<..<<<.<<.<......<<<<<<<<.>>>>>>>>........>>>.>>>.>...........>>>...>>>>>>>>>>...........................<<<<<<..>>>>>>....<<...<<..<<...<....<.<<<<<...<<...>>..<<<<<<.<<<<....>>>>.>>>>>>.>>>>>.>....>....>>.....>>..>>.........<<<<<<<....>>>>>>.>..................>>>.>>>>>...>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<......>>>>>>>..<<<<<..<<<...<..........[...>...>>>...>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<........<<<.<<<<<<<<<...<<<....<<<..<.<<<<..<<<<<.<.....>.>>>>>>>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.........>>>>>>>>.>..>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<............]..........<.....>...................>.>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<<<<<...>>>>>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<..<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..{{{..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<.>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<....<<<<<....>>>>.>...>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<<.<<<<<<<<<..>>>>>>>>>...<<<<<.....<<<<..<<.....<<...>>....>>..............<<<<<<<<...>.>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>>.<<<....>>>.>>))).......((((((..(((..>>>>>>.)))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]].....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<}}}.>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.....<<<<<<<.<<..<<<..<................<.<<<<....>>>>.>..................<<<..<<<<.......<.<<<<<<<......>>>>>>>.>.....>>>>..>>>..........>...>>>...>>>>>>>>><<<<<.<.............>.....<.<<<<<<<.<<.....<<<<....<<<<<......>>>>>...>>>>....>>....>>>>.>>>.>...>>>>>... .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.....(.....((((.(.(.....).))))).......)......(.((..((.....(...(.........((((..........(........).........(...)...(........).........))))....)...)....))..)).)..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.(.....(..((.(.(.((....((.((.(..(.....(..(((..(((.(....(((((.(((..(((((((((.)))..))))))))))))))))).).)).)....)...)..)).).))....))..)).))..)...(((((((.((((.(((((.(((........((.(((.(((.......((((((((.))))))))........))).)))))...........)))...))))).))))...........................((((((()))))))...(.(...(((.((...(.(..(.((((.(..((...))..((((((.((((....)))).))))))).)))).)...))....))....))).).)...........(((((....))))).....................))).))))....))))...)))))))).[((((........))))((((((....(((((((((((((..(((..((((..........)))..)..)))...((....))...(((((((......)))))))..(((((...((...(..............)...))....))))).(((((((((.((((......))))))))))).))....)))))))))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((........(((.((((((((....(((....(((..(.((((.(.(.(..(.....)..).)))))).)..)))..)).)....))))))....((((((((.(......)))))))))....))))))))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.(.((((((((.......(((((.(((...(...........)...))).....(...((......)).).)))))...)))))))).))))..........]]].)....))))))))))...)))))))((((((.(.................................................).))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((..(((((((....(.....)..))))))....[[(((.((...((..(.(((....))).....)....((.(((((((((...)))))))))))......))....))...(.(((........))).)]]((((....(((((...(((((((....)))))))..((((....)))...(...((((.(...(((((((((((((((((((((((..{{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....).))))...)).........)).))).)))).))).))).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((.)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((....(((.....((((....)))).....))).))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.(((((((((.(((((((((())))))))))...(((((.....((((..(.[.....(...)......)].............(((((((......)))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(.(.(((......))).)...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}}.)))))..)).))...))))...)))).(((....((((.............))))....)))..)))...).))))))......(((((..((..((......(................(((....)))................)....(((..((((.....(.(.(((((((......)))))))).)....))))..)))...............))...)).))))).(((((.(..(.......)..).....(.(((((((.((.....((((.(..(((((......)))))..)))))....))....)))).))).)...)))))... Human ribosome nascent chain complex (PCSK9-RNC) stalled by a drug-like molecule with AP and PE tRNAs; 28S ribosomal RNA 6om0 u 76 3.1 RF00005 URS0000EEAD11_9606 31160784 0030533 0006412 9606 gcccggauagcucagucgguagagcaggggauuccguauccccguguccuugguucgauuccgaguccgggcacca ..<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>...... ..(((((..((.(........).))..((((.......))))......((.((.......)).)))))))...... Human ribosome nascent chain complex (PCSK9-RNC) stalled by a drug-like molecule with AP and PE tRNAs; tRNA 6om0 v 76 3.1 RF00005 URS0000EEAD31_9606 31160784 0030533 0006412 9606 ugcccgguagccccgaagguagagcaggggauuccgaauccccguguccuugguucgauuccgaguccgggcacca .<<<<<<..<<............>>.<<<<<<.....>>>>>>......<<<.........>.>>.>>>>>>.... .(.((((..(.....[..[.....).(((((.......)))))......((((.(].)].)).)).)))).).... Human ribosome nascent chain complex (PCSK9-RNC) stalled by a drug-like molecule with AP and PE tRNAs; tRNA 6om0 w 10 3.1 31160784 9606 uuacggcggu .......... .......... Human ribosome nascent chain complex (PCSK9-RNC) stalled by a drug-like molecule with AP and PE tRNAs; mRNA 6om6 1 2903 3.1 RF02540,RF02541 URS0000B21DEA_562 33741965 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaacccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<......>>>...................>>>>>>>>>>>.......<<<<.<.<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<.........>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<.....<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>....>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<....<....>.....>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<....<.......<<<<<<<<....>>>>>>>>....>..............>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......((((.((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))).))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..(((......)).)............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((................))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(.(((..(.(.....{...((..(((..((((.......))))..))).....(..(((......))))..)).....).)..))).).))...........]]].)...))))))))))...)))))))(((((..((....))..)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((((.(..........(((...(.(.......((..(((....)))..))....).).............))).).)))).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(.(((((....))).)).)....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Structure of trans-translation inhibitor bound to E. coli 70S ribosome with P site tRNA; 23S ribosomal RNA 6om6 2 1534 3.1 RF00177,RF01959,RF01960 URS000081169C_562 33741965 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<......>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<.......<<<....>>>......>>>>..<<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>>.<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<.<<<....>>>.>>....<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((.((((........))))..)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....(((.((...(....).)).))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....(((.((((.......)))).))).....)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....))))))).............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Structure of trans-translation inhibitor bound to E. coli 70S ribosome with P site tRNA; 16S ribosomal RNA 6om6 3 120 3.1 RF00001 URS0000049E57_562 33741965 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>>.<<...<...<<<<<<<<...>>>>>>>>.....>.>>...>>>>>>>>>>. .(((((((((.....((((((((....(((.(((...(.....)...)))...)))...)))))).)).((.......((.(((((...))))).)).......))...))))))))).. Structure of trans-translation inhibitor bound to E. coli 70S ribosome with P site tRNA; 5S ribosomal RNA 6om6 5 76 3.1 RF00005 URS00021ED8FA_562 33741965 0030533 0006412 562 gcgggaauagcucauuugguagagcacgaccuugccaaggucggggucgcgagnucgagucucguuucccgcucca <<<<<<<..<<<..........>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... .((((((..(((......[...))).(((((.......)))))......((((..]....)))).))))))..... Structure of trans-translation inhibitor bound to E. coli 70S ribosome with P site tRNA; tRNA(gly) 6om7 S2 1714 3.7 RF01960,RF01959,RF00177 URS0000EEAD2D_9606 31160784 0003735 0005840 9606 uaccugguugauccugccaguagcaunugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuauggunccuunggucgcucgcuccucucccacuuggauaacugugguanuucuagngcuaauanaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgccccccguggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcnaauuacccacucccgacccgggganguagugangaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugagucnacuuuaaauccuuccgcgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauancguauauuaaaguugcugcaguunaaaagcucguaguungaucuugggagcgggcguccccgcccucucggccggggcccgaagcauuuacuuugaaaaaanuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagancgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccacnaggaguggagccugcggcuuaauuugacncaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggcnguucuuaguugguggagcgauuugucugguuaauucngauaacgaacgagacucuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauunagucccugcccuuuguacacaccgnccgucgnuacuaccgauuggaugguuuagugaggcccucggaucggcccggagcgcugagaagacggucgaacuugncuaucuagaggaaguaaaagucgnancaagguuucnguaggugnnccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<.........<<<.<<<..<<....<<....<<..........>>...>>.>>......<<..<.....<<<.......<....<<<<<..................<<.....<<.<<.......>>.>>......>>.........<<<<......................>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<<......>>>>>>>>.>>.>>>...>.....>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>>>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>..>>>......>>.>.....<<.....<<..<.....>...>>.......>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<.......................<<................>>....<...<.<.......<<...<.......>.<<<<.......>>>>...>>......>.>.....>.........<.<<.<<..<<<...............>>>..>>.>>.>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>.>.>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<......<<<<<..<<<.<<<<<<......<<........>>..........<<<<<......<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<.<<<<<.....<<<...<<......>>...<<<......>>>......>>>....<<<...<...<<<<..<<<<<<<<<<<<.......>>>>.>>>>.....>>>>..>>>>..>.....<<<<<.....>>>>>........>>>.....>>.>>>.....>>>>>>>.......>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>..........<.<<<<<..........>>>>>>..........>>>>>.....<<<<<<<<.......>>>>>>>>...........>>>>>>>>>>.>>.......<<.<..<<<<.<<....<<...<<<.<<<..<<<<.<<...<<<<<.......>>>>>...>>.>>>>..>>>.>>>..>>....>>.>>>>...>.>>.........<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.....(....(((.....((.............((.....((.(((.....))).))......))......)).((((......................)))).(..(((((...(......)..)))))......)..(.((((.((((......)))))))))...)))...)...).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((....(((.]...)))..)))).)...)).).....(((...((...((....))...).)....)))....(.(...(...........)...)......)..((((([[....(.((((.....((..]])).......))))))))))..)))))).)))..[......(.([[...(.(.((...(((..(.......................((................))...((..((.(.......((..((.......)).(((.......)))....))......).))....))........(.((.(.(..(.................)..).).)).)....)....(((..(...(...(.((..((..((((((((...((........))......))))))))..)).......((....))...)).)..)...)...))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.((.(......).)))))))).)..)))...((..]]))...))...].))))).).(((......((((....))))....)))...]]].](((((.(((((((..(...(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.((..........)).))....).)))))...((.(((...(.(((((.....(((...(.(....).)..(.((......)))......)))....(((...(...((((..((((((((((((.......)))).)))).....))))..))))..).....(((((.....)))))........))).....)).))).....).))))).....).)))))...)).)))).))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....((((((((.......)))))))).......)...)))))))))).))..(.(..((.(..((((.((........(..(.(((..((((.((...((.(.........).))...)).))))..))).).)........)).))))...).))...)..)..((((((((......))))))))}........ Human ribosome nascent chain complex (PCSK9-RNC) stalled by a drug-like small molecule with AA and PE tRNAs; 18S ribosomal RNA 6om7 D 157 3.7 RF00002 URS0000005270_9606 31160784 0003735 0005840 9606 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>.............>>>..)...>>>....<<....>><<<<<<<<.......>>>>>>>>..................... .........................................((((((.[[....[)))...].(.(((......]].............)))..)...)))....((....))(((((((.........)))))))..................... Human ribosome nascent chain complex (PCSK9-RNC) stalled by a drug-like small molecule with AA and PE tRNAs; 5.8S ribosomal RNA 6om7 E 119 3.7 RF00001 URS00000F9D45_9606 31160784 0003735 0005840 9606 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>. (((((((((....((((((((.....((..((...(....)...))....))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))). Human ribosome nascent chain complex (PCSK9-RNC) stalled by a drug-like small molecule with AA and PE tRNAs; 5S ribosomal RNA 6om7 t 3607 3.7 RF02540,RF02543 URS0000EEAD2F_9606 31160784 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgcgcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcggcccggcggaucuuucccgcccccggggucggcgggggaccgucccccggaccggcgaccggccgccgccgggcgcauuuccaggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucggggcccccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcgcucuccccccugggggggccgggccaccccucccacggcgcgaccgcucucccagggggcggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccggggggccacgcgcgcgucccccgaagggggggacggcggagagcgcacggggucggcggcgacgucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgaggggcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcccacgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcgucgagaguggacgggagcggcggcccggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcuggcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacguuuuuucacugacccggugaggcgggggggcgagcccgaggggcucucgcuucuggcgccaagcgcccgcccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucgccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccgguccccgccggggguccggugcggagugcccuucguccugggaaacggggcgcggccggaaaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuuguc .........................<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<.........<<<<<.<......>.>>>>>..........>...<.<<..<<.....<...<....<....<<<<........<.<........>.>..................................>>>>.>..>...>....>>..>>.>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<......>>>..................................<<<<<<<<..<<<.......<..<<.<.<<<<....<<.<..<..<.........<<.<.<<......<<<<<.<<<..<<<<<<<<...>>..>>>>>>>>>>>>>>.>>.>.>>..........>..>..>.>>....>>>>.>.>>..>..<<<<<<<<.<<<<<<<<<<.<<<........<..<<<.<<<.......<<<<<<<<.>>>>>>>>........>>>.>>>.>...........>>>...>>>>>>>>>>...........................<<<<<<..>>>>>>....<<...<<..<<...<....<.<<<<<...<<...>>..<<<<<<.<<<<....>>>>.>>>>>>.>>>>>.>....>....>>.....>>..>>..........<<<<<<....>>>>>>....................>>>.>>>>>....>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<......>>>>>>>..<<<<<..<<<...<..............>...>>>...>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<........<<<.<<<<<<<<<...<<<....<<<..<.<<<...<.<<<.........>>>.>.>>>.>..>>>..>.>>...>>>>>>>....<<<<<<<<.<......>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.....<.<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>.>.>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<.................................................>.>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<<<<<...>>>>>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<..<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>.>>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<...............>>>>><<.<<<<<<<<<<<.>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<....<<<<<....>>>>.>...>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<<<..>>>>>>>>>...<<<<<.....<<<<....................................<<<<<<<......>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))......<<<<<<<..<<<..)))))).>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>........<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>.....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<]]].>>>>>..>>.>>...>>>>...>>>><<<<....<<<<<...........>>>>>....>>>>.>>>...>.>>>>>>......<<<<<..<<..<<<..<................<.<<<<....>>>>.>..................<<<..<<<<.......<.<<<<<<<......>>>>>>>>......>>>>..>>>..........>...>>>...>>.>>>>>.<<<<<.....................<.<<<<<<<.<<.....<<<<....<<<<<......>>>>>...>>>>....>>....>>>>.>>>.>...>>>>>... .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.....(.....(((((..(.....).))))).......)......(.(...((.....(...(.........((((..........(........).........(...)...(........).........))))....)...)....))...).)..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((....(..((.(.(.((....(.(((.(..(.....(..(((..(((.(....(.(((.((...(((((((((.)))..)))))).))))).)))).).)).)....)...)..)).).))....))..)).))..)...(((((((.((((.(((((.(((........((.((..(((.......((((((((.))))))))........)))..))))...........)))...))))).)))).........................(.((((((..))))))...(.....((..((...(.((((.((((.(..((...))..((((((.((((....)))).))))))).)))).).))))....)).....))...)..........((((((....))))).).........).........))).))))...)))))...)))))))).[((((........))))((((((....(((((((((((((..(((..((((..........)))..)..)))...((....))...(((((((......)))))))..(((((...((...(..............)...))....))))).((((..(((.((((......)))))))..)).))....)))))))))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((........(((.((((((((....(((....(((..(.(((...((.((.(.....).)).)).))).)..)))..)).)....))))))....((((((((.(......)))))))))....))))))))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.(.((((((((.......(((((.(((...(...........)...))).........(........)...)))))...)))))))).))))..........]]].)....))))))))))...)))))))((((((.(.................................................).))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((..(((((((....(.....)..))))))....[[(((.((...((....(((....)))..........((.(((((((((...)))))))))))......))....))...(.(((........))).)]]((((....(((((...(((((((....)))))))..((((....)))...(...((((.(...(((((((((((((((((((((((..{{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....).))))...)).........)).))).)))).))).))).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((.)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((....(((.....((((....)))).....))).))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.(((((((((.(((((((((())))))))))...(((((.....((((..(.......(...)......)..............(((((((......)))))))..))))..)))))....)))))))))..)))))..(((......[)).)(((((...........].)))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(.(.(((......))).)...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).))))).....((.(((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}}.)))))..)).))...))))...)))).((((...((((.............))))...))))..)))...).))).))......(((((..((..(((.....(.............(..(((....)))..).............)....(((...(((.....(.(.(((((((......)))))))).)....)))...)))..............)))...)).))))).(((((.(..(.......)..).....(.(((((((..(.....((((.(..(((((......)))))..)))))....).....)))).))).)...)))))... Human ribosome nascent chain complex (PCSK9-RNC) stalled by a drug-like small molecule with AA and PE tRNAs; 28S ribosomal RNA 6om7 v 76 3.7 RF00005 URS0000EEAD31_9606 31160784 0030533 0006412 9606 ugcccgguagccccgaagguagagcaggggauuccgaauccccguguccuugguucgauuccgaguccgggcacca ..<<<<<..<<............>>.<<<<<<.....>>>>>>......<<<<.......>>.>>.>>>>>..... .(.((((..(.....[........).(((((.......)))))......((((.(..)].)).)).)))).).... Human ribosome nascent chain complex (PCSK9-RNC) stalled by a drug-like small molecule with AA and PE tRNAs; P/E site tRNA 6om7 w 10 3.7 31160784 9606 uuacggcggu .......... .......... Human ribosome nascent chain complex (PCSK9-RNC) stalled by a drug-like small molecule with AA and PE tRNAs; mRNA 6om7 u 76 3.7 RF00005 URS0000EEAD11_9606 31160784 0030533 0006412 9606 gcccggauagcucagucgguagagcaggggauuccguauccccguguccuugguucgauuccgaguccgggcacca ..<<<<...<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>.>>>>...... ..(.(((..((.(........).))..((((.......))))......((.((.......)).))))).)...... Human ribosome nascent chain complex (PCSK9-RNC) stalled by a drug-like small molecule with AA and PE tRNAs; A/A site tRNA 6ope QA 1500 3.1 RF00177,RF01959,RF01960 URS000080E226_300852 32601241 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggggucuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<...>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<.<<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<<....>>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((.(((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..)))))..))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((........((((((..(((.(((....))).)))....(((....)))...))))))....((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...(...(((.....))).)....))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Crystal structure of tRNA^ Ala(GGC) U32-A38 bound to near-cognate 70S A site; 16S rRNA 6ope QV 77 3.1 RF00005 URS000041AF00_562 32601241 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of tRNA^ Ala(GGC) U32-A38 bound to near-cognate 70S A site; P-site tRNAfMet 6ope QX 18 3.1 32601241 562 ggagguaaaaauggcaaa .................. .................. Crystal structure of tRNA^ Ala(GGC) U32-A38 bound to near-cognate 70S A site; mRNA 6ope QY 75 3.1 RF00005 URS0001A24B3D_562 32601241 0030533 0006412 562 gggcuauagcucagcugggagagcgcuugcuuggcaagcaagaggucagcgguucgaucccgcuuagcuccacca <<<<<...<<<<........>>>>.<<<<<<.....>>>>>>......<<<.........>>>..>>>>>..... ..(((....(............)...((((.......))))........((.........))...)))....... Crystal structure of tRNA^ Ala(GGC) U32-A38 bound to near-cognate 70S A site; A-site tRNAAla(GGC) U32-A38 6ope RA 2882 3.1 RF02540,RF02541,RF00002 URS00001698E8_300852 32601241 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<..>...>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<<........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>.>>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....(())...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((...((((((......)))).))...)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((........((((.((...(((.........)))...)).....(...((......)).).))))....)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((.((((((((.(.........(((((..(((......((((((((....))))))))...)))............)))))).)))))))).)))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].]......((((((.((..]]]]..))))))))......)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(..(((.....))).....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))...)))) Crystal structure of tRNA^ Ala(GGC) U32-A38 bound to near-cognate 70S A site; 23S rRNA 6ope RB 120 3.1 RF00001 URS00005F2F4B_300852 32601241 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).)))))))))). Crystal structure of tRNA^ Ala(GGC) U32-A38 bound to near-cognate 70S A site; 5S rRNA 6ope XA 1500 3.1 RF00177,RF01959,RF01960 URS000080E226_300852 32601241 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggggacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<...>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<......>>>..>>>>>>>>.<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((.(.).)))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......(..........)..........(((((((..(...((((((((..(((((((....)))))))....(((....)))...))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((.......(((.....)))......)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((.(((((....))))).)))}.. Crystal structure of tRNA^ Ala(GGC) U32-A38 bound to near-cognate 70S A site; 16S rRNA 6ope XV 77 3.1 RF00005 URS000041AF00_562 32601241 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of tRNA^ Ala(GGC) U32-A38 bound to near-cognate 70S A site; P-site tRNAfMet 6ope XX 18 3.1 32601241 562 ggagguaaaaauggcaaa .................. .................. Crystal structure of tRNA^ Ala(GGC) U32-A38 bound to near-cognate 70S A site; mRNA 6ope XY 75 3.1 RF00005 URS0001A24B3D_562 32601241 0030533 0006412 562 gggcuauagcucagcugggagagcgcuugcuuggcaagcaagaggucagcgguucgaucccgcuuagcuccacca <<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>......<<<.........>>>.>>>>>>..... (.(((...((............))..((((.......))))........(...........)...))).)..... Crystal structure of tRNA^ Ala(GGC) U32-A38 bound to near-cognate 70S A site; A-site tRNAAla(GGC) U32-A38 6ope YA 2883 3.1 RF02540,RF02541,RF00002 URS00001698E8_300852 32601241 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<..>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>...<.....<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>....>.>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<..>...>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<<.....>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((..)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(.(...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..).))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....(())...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((...((((((......)))).))...)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......(((((..(...(.............)...)......(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((.((((((.(.........(((((....(......((((((((....))))))))...)..............)))))).)))))).)))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(..((.......)).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal structure of tRNA^ Ala(GGC) U32-A38 bound to near-cognate 70S A site; 23S rRNA 6ope YB 120 3.1 RF00001 URS00005F2F4B_300852 32601241 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> (((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).))))))))))) Crystal structure of tRNA^ Ala(GGC) U32-A38 bound to near-cognate 70S A site; 5S rRNA 6ord QA 1500 3.1 RF00177,RF01959,RF01960 URS000080E226_300852 32601241 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>....<<<....>>>...>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((())))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((((((....))))))).(..(((....)))..).)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of tRNA^ Ala(GGC) U32-A38 bound to cognate 70S A site; 16S rRNA 6ord QV 77 3.1 RF00005 URS000041AF00_562 32601241 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of tRNA^ Ala(GGC) U32-A38 bound to cognate 70S A site; P-site tRNAfMet 6ord QX 18 3.1 32601241 562 ggagguaaaaauggccaa .................. .................. Crystal structure of tRNA^ Ala(GGC) U32-A38 bound to cognate 70S A site; mRNA 6ord QY 76 3.1 RF00005 URS0001A24B3D_562 32601241 0030533 0006412 562 ggggcuauagcucagcugggagagcgcuugcuuggcaagcaagaggucagcgguucgaucccgcuuagcuccacca <<<<<<...<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>.>>>>>>.... ((.(((...((((........)))).(((((.......))))).....(((((.......))))).))).)).... Crystal structure of tRNA^ Ala(GGC) U32-A38 bound to cognate 70S A site; A-site tRNAAla(GGC) U32-A38 6ord RA 2867 3.1 RF02540,RF02541,RF00002 URS00001698E8_300852 32601241 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<.......>>>....>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...((((((((.....))))))))....{.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).))))....(((((((((.[.....)))))))))....}.(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((()))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((.(.((.(((......)))..)))..)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......(((((.(((..(((.......)))...))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))(((((((())))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((((.((((.(.........(((((..(((.......((((.(......).))))....)))............)))))).)))).)))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(((...)).....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))...)))) Crystal structure of tRNA^ Ala(GGC) U32-A38 bound to cognate 70S A site; 23S rRNA 6ord RB 120 3.1 RF00001 URS00005F2F4B_300852 32601241 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of tRNA^ Ala(GGC) U32-A38 bound to cognate 70S A site; 5S rRNA 6ord XA 1504 3.1 RF00177,RF01959,RF01960 URS000080E226_300852 32601241 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<<....>>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((((((....))))))).(..(((....)))..).)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of tRNA^ Ala(GGC) U32-A38 bound to cognate 70S A site; 16S rRNA 6ord XV 77 3.1 RF00005 URS000041AF00_562 32601241 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of tRNA^ Ala(GGC) U32-A38 bound to cognate 70S A site; P-site tRNAfMet 6ord XX 18 3.1 32601241 562 ggagguaaaaauggccaa .................. .................. Crystal structure of tRNA^ Ala(GGC) U32-A38 bound to cognate 70S A site; mRNA 6ord XY 76 3.1 RF00005 URS0001A24B3D_562 32601241 0030533 0006412 562 ggggcuauagcucagcugggagagcgcuugcuuggcaagcaagaggucagcgguucgaucccgcuuagcuccacca <<<<<<...<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>.>>>>>>.... ((.((....((((........)))).(((((.......))))).....(((((.......)))))..)).)).... Crystal structure of tRNA^ Ala(GGC) U32-A38 bound to cognate 70S A site; A-site tRNAAla(GGC) U32-A38 6ord YA 2867 3.1 RF02540,RF02541,RF00002 URS00001698E8_300852 32601241 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<.......>>>....>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...((((((((.....))))))))....[.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).))))....(((((((((.{.....)))))))))....].(((((}.[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((()))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((.(.((.(((......)))..)))..)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......(((((.(((..(((.......)))...))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))(((((((())))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((((.((((.(......[..(((((..(((.......((((.(......).))))....)))..........].)))))).)))).)))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(((...)).....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))...)))) Crystal structure of tRNA^ Ala(GGC) U32-A38 bound to cognate 70S A site; 23S rRNA 6ord YB 120 3.1 RF00001 URS00005F2F4B_300852 32601241 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of tRNA^ Ala(GGC) U32-A38 bound to cognate 70S A site; 5S rRNA 6ore 1 2903 2.9 RF02540,RF02541 URS00021ED9BC_562 31189921 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaacccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>...[.....<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))....].]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<.......>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<.<..<<<............<<<<<...<.......<<<<<<<<....>>>>>>>>....>.............>>>>>...>>>..>.>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((.((.........))..))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..)))........(((......)))..)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((..((....))..)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((...((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).)))..)).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((..((((....((((...............(..(((......(.((((((....)))))).)...)))............)......))))....))))..))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(.(((((....))).)).)....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Release complex 70S; 23S ribosomal RNA 6ore 2 1534 2.9 RF00177,RF01959,RF01960 URS000081169C_562 31189921 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<........>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<....<.<<<....>>>>................>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((........))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((((.......)))))))).....)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((......(((((((....(..((....))..)...............))))).))..((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Release complex 70S; 16S ribosomal RNA 6ore 3 120 2.9 RF00001 URS0000049E57_562 31189921 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Release complex 70S; 5S ribosomal RNA 6ore 5 76 2.9 RF00005 URS0000EEACF3_562 31189921 0030533 0006412 562 gcggggungagcagccuggnagcucgucgggnugaaaacccgaagaucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Release complex 70S; P-tRNA 6orl 1 2903 3.5 RF02540,RF02541 URS00021ED9BC_562 31189921 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaacccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((...<<<.....<...<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>..>...>>>.........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<........>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<......<...........>.......>>>>.>>>..>>.>.....>>>>>>>.>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<...<........<<<<<...................................<<......>>...>>>>>....>...>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<......>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<.<..<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>>....<<<<...<<<<.<<<<<<<.<<.....>>>>>>>>>...>>>>...>>>>........<<<<<....>>>>>....>>>>>...>>>...>>>>.........>>>>...>.....>..>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<......<.<<<<<..<......>...>>>>>>.......>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<..<<<.<<<<<.<<<<<<<.....<..............<<<<............<...<<<<....>>>>...>...................>>>>.....>.....>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>...>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<.<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>..>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((..((((((.....(((..(((((((.(((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...(((..((((......(.((.((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))).)).)...))))........((((((((..[......))))))))......(((((].[[[[)))))..)))......)).).))))).))...............((....))....))......(..((((.....))))............)).....))))))..)).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))...(.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).)...((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((....(................)....)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((...((.....{.(((((..((...................))......(...((......)).).)))))...))...))))).))...........]]].)...))))))))))...)))))))(((((..(......)..)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]]((((((((..(((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((.((.((((.((.....)))))).))...))))..[))))...))(..((.((....)).))...))))))...)))...))))(..).....))))...))....)..)))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))....((((((.....(((....))).......))))))..}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((.((..(..(..............((..(.(..........((.(....).)).......).)............))......).)..)).)))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((....((((((...(((((.........))))).....((][.[[[))....))))))....((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(.(((((....))).)).)....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). RF1 pre-accommodated 70S complex at 24 ms; 23S ribosomal RNA 6orl 2 1534 3.5 RF00177,RF01959,RF01960 URS000081169C_562 31189921 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<..........>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<........>>>>......>>.>.....<<<....>>>....<<<<<<..........>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>...>>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<.......<<<....>>>......>>>>.....<<<<<......<.<<<<...............>>>>.>........>>>>>.......<<<<<(((...<<<<<.....<..))).>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<.<......<<........>>..........<<<<<<<......<<<<<<<....<.<<......>>>......<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.<.....<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<<..<<<.....>>>>>.....>>>>>>.....<<<<<.....>>>>>........>>>>.....>...>>>...>>>>>>>>>...>>>>>>>...>..>>>>>>>>.....<<<<<<<.....<<<..<....<<<....>>>....>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<...<<....>>..>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((...((((.(..........).)).)).))..)))))......(((......(((((((..((...((((((..(.((.....((((((....))))))......)).).....(((....)))....((((((..........))))))..))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((...........)))))).....)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......(.((((.....)))).)....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((.......(((....)))..................)))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....(((((..(((...((....))..))).)))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... RF1 pre-accommodated 70S complex at 24 ms; 16S ribosomal RNA 6orl 3 120 3.5 RF00001 URS0000049E57_562 31189921 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<......<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>....>>>>>>>>>. ((((((((((.....((((((((....(..((((...(.....)...))))....)...)))))).)).((.......((((((((...)))))))).......))...)))))))))). RF1 pre-accommodated 70S complex at 24 ms; 5S ribosomal RNA 6orl 5 76 3.5 RF00005 URS0000EEACF3_562 31189921 0030533 0006412 562 gcggggungagcagccuggnagcucgucgggnugaaaacccgaagaucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... RF1 pre-accommodated 70S complex at 24 ms; P-tRNA 6osi QA 1511 4.14 RF00177,RF01959,RF01960 URS000080DFED_300852 33016876 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggggucuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucaccuccuuu ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.....<<<<<..>>.>>>.....>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>....<<<<.<<<<<....>>>>>.>>>>...<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<............>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<.<<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<...<<<<<<<.........<........>...........<<<<<<<.......<<<<<<...<<<<<<<....>>>>>>>...<<<......>>>...>>>>>>...<<.<<....<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<...<<<.....>>>>......>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>..>>>>....>>>>>>>......>>>>>>>......<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>..........<.<<<<<<........>>>>>>>..........>>>>>>.....<<<<<<..........>>>>>>.......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.............. ....((((..[.[[[..)))).((.(.(((((..(((((((((....(((.(((..(((..((....(((.(.....).)).)...)))))......(((.......(((((((..((...((((.((.(((((....((((((....)))))).....))))).....(((.(((((....))))).)))....((.(...).)).)).))))..))))))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[....(((((.....((..]])).......))))))))))..)))))).))..........((([....(.((((....((.((((((..((((((((((......((((((.....))))))....))))))))..)).))))))..(((((((((...((((((.(....((((((.....(........)........))))))....).......((....))..))))))..))))).)))..)))....))))....((((((...((...((((.........))))...))))))))......{...(((.((..((.((((.((...)).)))).))...((...])).....)).))))))).(((......((((....))))....)))...]]].](((((.(((((((.....(((((....((.(.(........(..........)........(.(((.((...(...(.(.(((...((.(.(......).).))...(((......)))...))).).)).((.(.(...((.(((.(....((.((((((....)))...(((......)))...))).)).....((((..(....(...(...(((.....)))).....)....)........((......))..........)))).....).).))....)).).))).....).))))).....).).))........((.(((.....(((..((..((((....))))..))....))).....))).))...........(.(.((..(.......).)).))..........))))).......(((..............))).............)))))))))).))..(.(..((.(..(((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).)))...).))...)..)..(((((((((....)))))))))}............. Unmodified tRNA(Pro) bound to Thermus thermophilus 70S (near cognate); 16S rRNA 6osi QV 68 4.14 RF00005 URS00001DEEBE_300852 33016876 0030533 0006412 300852 cggugauuggcgcagccugguagcgcacuucgaaggggucggagguucgaauccucuaucaccgacca <<<<<<<..<<<<.........>>>>.<<<..>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.........)))).(((..))).....(((((.......)))))))))))).... Unmodified tRNA(Pro) bound to Thermus thermophilus 70S (near cognate); tRNA(Pro) 6osi QX 19 4.14 33016876 300852 ggcaaggagguaaaacccu ................... ................... Unmodified tRNA(Pro) bound to Thermus thermophilus 70S (near cognate); mRNA 6osi RA 2882 4.14 RF02540,RF02541,RF00002 URS00021ED94F_300852 33016876 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<.....<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>.>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<..>...>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..<<<.........>>>..>>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<..<<<<<<<...<<.......>>...>>>>>>>...>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<<.....>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[[)))...].((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((......(...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)..)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....(())...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((.(.((((((......)))).)))..)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((........((((..((..(((.........)))..))......(...((......)).).))))....)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((.(((((((((((..(.........((.((..(((......((((((((....))))))))...)))............)).)))..))))))))))).)))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(...(........)..(..(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))..))))) Unmodified tRNA(Pro) bound to Thermus thermophilus 70S (near cognate); 23S rRNA 6osi RB 120 4.14 RF00001 URS00005F2F4B_300852 33016876 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> ((((((((((.....((((((.(....(((.((....(.....)....))...)))...).)))).))(((.......((.(((((....))))).)).......)))..)))))))))) Unmodified tRNA(Pro) bound to Thermus thermophilus 70S (near cognate); 5S rRNA 6osi XA 1515 4.14 RF00177,RF01959,RF01960 URS000080DFED_300852 33016876 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucaccuccuuu ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<.<.......>.>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>...>>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<..))).>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<.<<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<...<<<<<<<........<<........>>..........<<<<<<<.......<<<<<<...<<<<<<<....>>>>>>>...<<<......>>>...>>>>>>..<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<...<<<.....>>>>......>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>......>>>>>>>......<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>.........<<.<<<<<<........>>>>>>>>.........>>>>>>.....<<<<<<..........>>>>>>.......>>...>>>>>>>>>>.>>.......<<...<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>....>>.........<<<<<<<<<....>>>>>>>>>.............. ....((((..[.[[[..)))).((((.(((((...((((((((....(((.(((..(((..((.(((((((.(.......).))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.((.((....)).)).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).)))))...((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((.(((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..)))))..))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.....(.(.(....((..(.........((........))........(.((..(((..(...(((((((...((((((......))))))...(((......)))...))))))))....(((...((((((......((.((((((....)))...(((......)))...))).)).....((((.((.(..(...(...(((.....)))).....).)..)).....(((((....)))))........)))).......).)))...)).)))......)).).)))......)..))........((((((.....(((..(((.((((....))))).))....))).....)))))).......(....((.((............)).))....).....).).).....(((((..............)))))...........)))))))))).)).......((...((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))....))..........((((((((....)))))))).}............. Unmodified tRNA(Pro) bound to Thermus thermophilus 70S (near cognate); 16S rRNA 6osi XV 68 4.14 RF00005 URS00001DEEBE_300852 33016876 0030533 0006412 300852 cggugauuggcgcagccugguagcgcacuucgaaggggucggagguucgaauccucuaucaccgacca <<<<<<<..<<<<.........>>>>.<<<..>>>.....<<<<<.......>>>>>>>>>>>>.... ((((.((..((((.........)))).((....))......((((.......)))).)).)))).... Unmodified tRNA(Pro) bound to Thermus thermophilus 70S (near cognate); tRNA(Pro) 6osi XX 19 4.14 33016876 300852 ggcaaggagguaaaacccu ................... ................... Unmodified tRNA(Pro) bound to Thermus thermophilus 70S (near cognate); mRNA 6osi YA 2883 4.14 RF02540,RF02541,RF00002 URS00021ED94F_300852 33016876 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<..>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<..>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<..<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>...>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<..<<<<<<<...<<.......>>...>>>>>>>...>>>.>.......<.<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>......>>>..>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<.....<....>....>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> 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Unmodified tRNA(Pro) bound to Thermus thermophilus 70S (near cognate); 23S rRNA 6osi YB 120 4.14 RF00001 URS00005F2F4B_300852 33016876 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> (((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).))))))))))) Unmodified tRNA(Pro) bound to Thermus thermophilus 70S (near cognate); 5S rRNA 6osk 1 2903 3.6 RF02540,RF02541 URS00021ED9BC_562 31189921 0003735 0005840 562 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<<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<....<.<<<<.....>>>>..>....>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<......<<.......>>......>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<.<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>>.<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>.<..<<<<<....>>>>>...>>>>>>...>>>...>>>.>........>>>>...>>.....>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<....<.<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<......<.<<<<<..<<....>>...>>>>>>.......>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<.<...................<<<..<<...........<<<<....>>>>........>>............>>>..........>.>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....(((((((...[.......)))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((.((....)).)))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))...(.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).)...((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((.............).))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.((.....(.........).....)).........((......))...)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((..(......)..)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(...((........))....))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((..((....(...............(....(............((....)).........)..............).......)...))..)))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).).....((.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..))....(.(((((....))).)).)....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((....(((...(((((((((((}}}.))))))..)))))...)))..)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). RF1 accommodated 70S complex at 60 ms; 23S ribosomal RNA 6osk 2 1534 3.6 RF00177,RF01959,RF01960 URS000081169C_562 31189921 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<..........>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<......>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<.<<<....>>>>>...............>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<...<<....>>..>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((((..........)))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....(((.((..((....))).)))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((.(.......).)))))).....)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.(((((((((.......((((((.....)))))).....)))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((.((((((..((((((((((......((........))..........(((((((..(...(((((((..((..(((....)))..)).............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(.(((((.....(((..((...(((....)))...))....))).....))))).)......(....(((((((........)))))))....)..)..))))))....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....(((((..((((..((....)).)))).)))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... RF1 accommodated 70S complex at 60 ms; 16S ribosomal RNA 6osk 3 120 3.6 RF00001 URS0000049E57_562 31189921 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<......<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>....>>>>>>>>>. ((((((((((.....((.(((((....(((((((...(.....)...))))..)))...)))))..)).((.......((((((((...)))))))).......))...)))))))))). RF1 accommodated 70S complex at 60 ms; 5S ribosomal RNA 6osk 5 76 3.6 RF00005 URS0000EEACF3_562 31189921 0030533 0006412 562 gcggggungagcagccuggnagcucgucgggnugaaaacccgaagaucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>......<<<<.......>>>>.>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... RF1 accommodated 70S complex at 60 ms; P-tRNA 6osq 1 2903 3.5 RF02540,RF02541 URS00021ED9BC_562 31189921 0003735 0005840 562 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<<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<.......>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<.........>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<<.<<....>>..>>>>>>..>....>>>>>>>>>..>>>>>.<<<<<.......>>>>>.........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<..<...................<<<..<<.......<<..<<<<....>>>>..>>....>>............>>>..........>..>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((.(((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).((((((((...........)))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((.((....)).)))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..(((.......))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((((...........)).))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.((....(............)...)).....(...(........).).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((..((....))..)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((.(...((.....)).).))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]]((((((((.((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(...((........))....))))))...)))...))))(..).....))))...))....)).)))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(.(((((..(((........(((((..((....))...)))))........))))))))...))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((((((..(....(..................((...............................))...................)....)..))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....((.((((.((..]]]]..)))))).)).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(.(((((....))).)).)....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).)))))).)). RF1 accommodated state bound Release complex 70S at long incubation time point; 23S ribosomal RNA 6osq 2 1534 3.5 RF00177,RF01959,RF01960 URS000081169C_562 31189921 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<......>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<<<<<<<<<<.......>>>>>>>>.>>.......>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<.......<<<<<<...<.<<<<....>>>>>...............>>>>>.>..<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((.(((..........)))..)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((.(((..........).)))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(..((((((((((.......)))))))).))..)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..(((((..(((......((........))..........(((((((..(.....(((((..(...(((....)))...).............)))))...).((.(((...((((((.(....((((((.((....))....(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)..))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... RF1 accommodated state bound Release complex 70S at long incubation time point; 16S ribosomal RNA 6osq 3 120 3.5 RF00001 URS0000049E57_562 31189921 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). RF1 accommodated state bound Release complex 70S at long incubation time point; 5S ribosomal RNA 6osq 5 76 3.5 RF00005 URS0000EEACF3_562 31189921 0030533 0006412 562 gcggggungagcagccuggnagcucgucgggnugaaaacccgaagaucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... RF1 accommodated state bound Release complex 70S at long incubation time point; P-tRNA 6ost 1 2903 4.2 RF02540,RF02541 URS00021ED9BC_562 31189921 0003735 0005840 562 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<<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<......>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<......<.<<<<<<<<<<<<.<<<...<<<<<......>>>>>(.......<<<......)>>>...>>>...>>>>>>>>>>>>>....>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<........>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<..........................>>>>.>>>..>>.>.....>>>>>>>.>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<...<........<<<<<...................................<<......>>...>>>>>....>...>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<......>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>...<<<<........>>>>.))<<<<<<<<<<.<<...<<<<....<<<<..<<<..<<<<<<<<<<<....[[....>>>>>>....<<<<...<<<<.<..<<<<.<<.....>>>>>>..>...>>>>...>>>>........<<<<<....>>>>>....>>>>>...>>>...>>>>.........>>>>...>>....>.>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<...........>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<......<.<<<<<..<<....>>...>>>>>>.......>>>>>>>>..>>>>>.<<<<<.......>>>>>.........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<..<<<.<<<<..<<<<<<<.....<..............<<<.....<.......<...<<<<....>>>>...>....>...............>>>.....>.....>>>>>>>...<<<.<<<<<<.....>>>>>>>>>.....>>>>.>>>...>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.....>>>>....>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<.<<<.<.<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>...>...>>>..>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<..]]..>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((.((....)).)))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((....(................)....)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((...((.......(((((..((....(.........)....))......(...((......)).).)))))...))...))))).))...........]]].)...))))))))))...)))))))(((((..(......)..)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((.(((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((.((.((((.((.....)))))).))...))))..[))))...))(..((.((....)).))...))))))...)))...))))(..).....))))...))....).))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........))))).........(..........(((((.......)))))..).......))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((.((....................(.....(..........((........)).......)...............)...........)).)))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((....((((((...(((((.........))))).....((][.[[[))....))))))....((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(.(((((....))).)).)....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). RF2 pre-accommodated state bound Release complex 70S at 24ms; 23S Ribosomal RNA 6ost 2 1534 4.2 RF00177,RF01959,RF01960 URS000081169C_562 31189921 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<..........>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<...<<.....<<<<<......>>>>>......>>.......<<<....>>>....<<<<<<..........>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>...>>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<.......<<<....>>>......>>>>...<.<<<<<......<.<<<<<<.<......>..>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<..))).>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<.<<<<<.....>>>>>.>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<.......<<<....>>>.....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<........<<........>>..........<<<<<<<......<<<<<<<....<.<<......>>>......<.<...>>..>>>>>.>>..<<.<<<..<<<<<<.<.....<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<...<<<.....>>>.>.....>>>>>>.....<<<<<.....>>>>>........>>>>.....>...>>>...>>>>>>>>....>>>>>>>......>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<..<<<<..<<....>>.>>>>.>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((...((((((..........)))).)).))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..........)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((((.......)))))))).....)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(..(((....)))..)..............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((...((((.(((..((((((((((((....(((.((.((((..((....)).)))))).)))...))))))))))))..))).))))....))...)..)..(((((((((....)))))))))}..... RF2 pre-accommodated state bound Release complex 70S at 24ms; 16S Ribosomal RNA 6ost 3 120 4.2 RF00001 URS0000049E57_562 31189921 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<......<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<........<<<<<<<...>>>>>>>........>>....>>>>>>>>>. ((((((((((.....((((((((....((.((((...(.....)...))))...))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). RF2 pre-accommodated state bound Release complex 70S at 24ms; 5S Ribosomal RNA 6ost 5 76 4.2 RF00005 URS0000EEACF3_562 31189921 0030533 0006412 562 gcggggungagcagccuggnagcucgucgggnugaaaacccgaagaucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... RF2 pre-accommodated state bound Release complex 70S at 24ms; P-tRNA 6ot3 1 2903 3.9 RF02540,RF02541 URS00021ED9BC_562 31189921 0003735 0005840 562 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<<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<.....<.<<<<<<<<<<<<.<<<....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<....<<<.<.......>.>>.>....>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<.....<.....<<..<<<<<..<<........<<<<<..<...<<<.........>>>...>.......................>>>>>....>>..>>>>>.>>...........)))..>..>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>...<<<<........>>>>.))<<<<<<<<<<<.<...<<<<....<<<<..<<<..<<<<<<<<<<<....[[....>>>>>><...<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>....>...<.<<<....>>>.>....>>>>>...>>>...>>>>.........>>>>...>.....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<..<<....>>...>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<...<...................<<<...............<<<<....>>>>......................>>>..........>...>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<.<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>..>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.]].>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((.((....)).)))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((....(.....).....))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((..((..(.............)..))......(...(........).).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((..(......)..)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((.....((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..((.((....)).))...))))))...)))...))))(..).....)))).........))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((.((....................((..(.(............((....)).........).)............))...........)).)))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..)))))).......(((..(.((((((...((.......))...))))))...).)).)........(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(.(((((....))).)).)....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..(.....(((((....)))))....)...))))).))).....))..).))))))))). RF2 accommodated state bound Release complex 70S at 24 ms; 23S ribosomal RNA 6ot3 2 1534 3.9 RF00177,RF01959,RF01960 URS000081169C_562 31189921 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<...<......>...>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..........>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<.......<<<....>>>......>>>>.....<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>.......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<.<<<<<.....>>>>>.>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<........<<........>>..........<<<<<<<......<<<<<<<...<<<<<<....>>>>>>..............>>>>>.>>.<<<.<<<..<<<<<<.<.....<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<.....>>>>>........>>>>.....>...>>>...>>>>>>>>>...>>>>>>>......>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<..<<<...<......>..>>>.>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(.(..((.((..((((.(............).).)))))..))).)......(((......(((((((..((...(((((((.(.((......(((((....))))).......)).).....(((....)))....((((((...(....).)))))).)))))))..)).)))))))((((...(((..((((((((.......))))))))))).....))))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(.(((....)))..))))).)).))))))..((((......((((....)))).....))))...(.(((((........((((((((.......))))))))..........)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))....(....)...))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... RF2 accommodated state bound Release complex 70S at 24 ms; 16S ribosomal RNA 6ot3 3 120 3.9 RF00001 URS0000049E57_562 31189921 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<......<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>....>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). RF2 accommodated state bound Release complex 70S at 24 ms; 5S ribosomal RNA 6ot3 5 76 3.9 RF00005 URS0000EEACF3_562 31189921 0030533 0006412 562 gcggggungagcagccuggnagcucgucgggnugaaaacccgaagaucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... RF2 accommodated state bound Release complex 70S at 24 ms; P-tRNA 6otr QA 1510 3.12 RF00177,RF01959,RF01960 URS000080DFED_300852 31501867 0003735 0005840 300852 guuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggcuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucaccuccuu ......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<...>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<......>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............. ......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((((((((.))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((((..(((((((....)))))))...((.(.....)))..))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}............ Dimeric E.coli YoeB bound to Thermus thermophilus 70S post-cleavage (AAU); 16S rRNA 6otr QV 77 3.12 RF00005 URS000041AF00_562 31501867 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Dimeric E.coli YoeB bound to Thermus thermophilus 70S post-cleavage (AAU); tRNA-fMet 6otr QW 77 3.12 RF00005 URS000041AF00_562 31501867 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(.(((.......))).)))))))..... Dimeric E.coli YoeB bound to Thermus thermophilus 70S post-cleavage (AAU); tRNA-fMet 6otr QX 17 3.12 31501867 562 caaggagguaaaaauga ................. ................. Dimeric E.coli YoeB bound to Thermus thermophilus 70S post-cleavage (AAU); mRNA 6otr RA 2891 3.12 RF02540,RF02541,RF00002 URS00001698E8_300852 31501867 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgggccggcccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu 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(((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...(((((((((..).))))))))....{.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).))))....(((((((((.[.....)))))))))....}.(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((((((()))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((...((((((......)))).))...))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((..(((.........)))..))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((.(((((((.((.....)))))))))......))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((.((((((((.(.........(((((..(((......((((((((....))))))))...)))............)))))).)))))))).)))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....((((((..((..]]]]..)).)))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((.....))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Dimeric E.coli YoeB bound to Thermus thermophilus 70S post-cleavage (AAU); 23S rRNA 6otr RB 122 3.12 RF00001 URS000080E212_300852 31501867 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga ..<<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> ..(((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).))))))))))) Dimeric E.coli YoeB bound to Thermus thermophilus 70S post-cleavage (AAU); 5S rRNA 6otr XA 1507 3.12 RF00177,RF01959,RF01960 URS000080DFED_300852 31501867 0003735 0005840 300852 guuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucaccuccuu ......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<..>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>....<<.......>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............. ......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((((((..))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((((..(((((((....))))))).(.(.((.....))).)))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}............ Dimeric E.coli YoeB bound to Thermus thermophilus 70S post-cleavage (AAU); 16S rRNA 6otr XV 77 3.12 RF00005 URS000041AF00_562 31501867 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Dimeric E.coli YoeB bound to Thermus thermophilus 70S post-cleavage (AAU); tRNA-fMet 6otr XW 77 3.12 RF00005 URS000041AF00_562 31501867 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca ...<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>....... ...((((..(((...........))).(((((.......))))).....(.(((.......))).)))))....... Dimeric E.coli YoeB bound to Thermus thermophilus 70S post-cleavage (AAU); tRNA-fMet 6otr XX 17 3.12 31501867 562 caaggagguaaaaauga ................. ................. Dimeric E.coli YoeB bound to Thermus thermophilus 70S post-cleavage (AAU); mRNA 6otr YA 2878 3.12 RF02540,RF02541,RF00002 URS00001698E8_300852 31501867 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu 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Dimeric E.coli YoeB bound to Thermus thermophilus 70S post-cleavage (AAU); 23S rRNA 6otr YB 122 3.12 RF00001 URS000080E212_300852 31501867 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga ..<<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> ..(((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).))))))))))) Dimeric E.coli YoeB bound to Thermus thermophilus 70S post-cleavage (AAU); 5S rRNA 6ouo 1 2903 3.7 RF02540,RF02541 URS00021ED9BC_562 31189921 0003735 0005840 562 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<<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<.....<.<<<<<<<<<<<<.<<<....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<....<<<.<.......>.>>.>....>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<.....<.....<<..<<<<<..<<........<<<<<..<...<<<.........>>>...>.......................>>>>>....>>..>>>>>.>>...........)))..>..>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>...<<<<........>>>>.))<<<<<<<<<<<.<...<<<<....<<<<..<<<..<<<<<<<<<<<....[[....>>>>>><...<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>....>...<.<<<....>>>.>....>>>>>...>>>...>>>>.........>>>>...>.....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<..<<....>>...>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<...<...................<<<...............<<<<....>>>>......................>>>..........>...>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<.<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>..>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.]].>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((.((....)).)))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((....(.....).....))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((..((..(.............)..))......(...(........).).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((..(......)..)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((.....((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..((.((....)).))...))))))...)))...))))(..).....)))).........))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((.((....................((..(.(............((....)).........).)............))...........)).)))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..)))))).......(((..(.((((((...((.......))...))))))...).)).)........(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(.(((((....))).)).)....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..(.....(((((....)))))....)...))))).))).....))..).))))))))). RF2 accommodated state bound 70S complex at long incubation time; 23S ribosomal RNA 6ouo 2 1534 3.7 RF00177,RF01959,RF01960 URS000081169C_562 31189921 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<...<......>...>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..........>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<.......<<<....>>>......>>>>.....<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>.......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<.<<<<<.....>>>>>.>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<........<<........>>..........<<<<<<<......<<<<<<<...<<<<<<....>>>>>>..............>>>>>.>>.<<<.<<<..<<<<<<.<.....<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<.....>>>>>........>>>>.....>...>>>...>>>>>>>>>...>>>>>>>......>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<..<<<...<......>..>>>.>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(.(..((.((..((((.(............).).)))))..))).)......(((......(((((((..((...(((((((.(.((......(((((....))))).......)).).....(((....)))....((((((...(....).)))))).)))))))..)).)))))))((((...(((..((((((((.......))))))))))).....))))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(.(((....)))..))))).)).))))))..((((......((((....)))).....))))...(.(((((........((((((((.......))))))))..........)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))....(....)...))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... RF2 accommodated state bound 70S complex at long incubation time; 16S ribosomal RNA 6ouo 3 120 3.7 RF00001 URS0000049E57_562 31189921 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<......<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>....>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). RF2 accommodated state bound 70S complex at long incubation time; 5S ribosomal RNA 6ouo 5 76 3.7 RF00005 URS0000EEACF3_562 31189921 0030533 0006412 562 gcggggungagcagccuggnagcucgucgggnugaaaacccgaagaucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... RF2 accommodated state bound 70S complex at long incubation time; P-tRNA 6owl A 14 2.0 31913615 32630 nnnnacuuaagucn .............. .............. RNA oligonucleotides with 3'-arabino guanosine co-crystallized with GMP; RNA (5'-R(*(LCC)P*(LCC)P*(LCC)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*R)-3') 6oxa QA 1510 3.25 RF00177,RF01959,RF01960 URS000080DFED_300852 31501867 0003735 0005840 300852 guuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggcuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucaccuccuu ......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<.>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<......>>>..>>>>>>>>.<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............. ......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((((((((.))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((((..(((((((....)))))))...((.(.....)))..))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}............ Dimeric E.coli YoeB bound to Thermus thermophilus 70S pre-cleavage (AAU); 16S rRNA 6oxa QV 77 3.25 RF00005 URS000041AF00_562 31501867 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Dimeric E.coli YoeB bound to Thermus thermophilus 70S pre-cleavage (AAU); P-site tRNA-fMet 6oxa QW 77 3.25 RF00005 URS000041AF00_562 31501867 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(.(((.......))).)))))))..... Dimeric E.coli YoeB bound to Thermus thermophilus 70S pre-cleavage (AAU); P-site tRNA-fMet 6oxa QX 20 3.25 31501867 562 caaggagguaaaaaugnnnc .................... .................... Dimeric E.coli YoeB bound to Thermus thermophilus 70S pre-cleavage (AAU); mRNA 6oxa RA 2891 3.25 RF02540,RF02541,RF00002 URS00001698E8_300852 31501867 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgggccggcccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<<<<<..>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<.<.<<<<<<......>>>>.>>>..>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<<.....>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...(((((((((..).))))))))....{.(((((((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).))))....(((((((((.[.....)))))))))....}.(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((((((()))))))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((...((((((......)))).))...))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((..(((.........)))..))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........(((((..(((......((((((((....))))))))...)))............)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....((((((..((..]]]]..)).)))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((.....))))....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))...)))) Dimeric E.coli YoeB bound to Thermus thermophilus 70S pre-cleavage (AAU); 23S rRNA 6oxa RB 120 3.25 RF00001 URS000080E212_300852 31501867 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> (((((((((((....((((((((....((((((....(.....)....)))..)))...)))))).))(((.......((.(((((....))))).)).......))).))))))))))) Dimeric E.coli YoeB bound to Thermus thermophilus 70S pre-cleavage (AAU); 5S rRNA 6oxa XA 1507 3.25 RF00177,RF01959,RF01960 URS000080DFED_300852 31501867 0003735 0005840 300852 guuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucaccuccuu ......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<<<<<<..>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>....<<.......>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............. ......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((((((..))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(.(((....))).).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((....((..(((((((....))))))).(.(.((....).)).)))....))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}............ Dimeric E.coli YoeB bound to Thermus thermophilus 70S pre-cleavage (AAU); 16S rRNA 6oxa XV 77 3.25 RF00005 URS000041AF00_562 31501867 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Dimeric E.coli YoeB bound to Thermus thermophilus 70S pre-cleavage (AAU); P-site tRNA-fMet 6oxa XW 77 3.25 RF00005 URS000041AF00_562 31501867 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .(.((((..(((...........))).(((((.......))))).....(.(((.......))).))))).)..... Dimeric E.coli YoeB bound to Thermus thermophilus 70S pre-cleavage (AAU); P-site tRNA-fMet 6oxa XX 20 3.25 31501867 562 caaggagguaaaaaugnnnc .................... .................... Dimeric E.coli YoeB bound to Thermus thermophilus 70S pre-cleavage (AAU); mRNA 6oxa YA 2875 3.25 RF02540,RF02541,RF00002 URS00001698E8_300852 31501867 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu 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(((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...(((((((((..).))))))))....{.(((((((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).))))....(((((((((.[.....)))))))))....}.(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....((((......))))(((((((((.(...(((((((((...(((...((((((((.(.((((((......)))).)))..))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((.(.......(((((.(((..(((.........)))..))).....(...((......)).).)))))...).)))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((((..))))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........(((((..(((......(((((.((....)).)))))...)))............)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.((((.....))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Dimeric E.coli YoeB bound to Thermus thermophilus 70S pre-cleavage (AAU); 23S rRNA 6oxa YB 120 3.25 RF00001 URS000080E212_300852 31501867 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> (((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).))))))))))) Dimeric E.coli YoeB bound to Thermus thermophilus 70S pre-cleavage (AAU); 5S rRNA 6oxi QA 1510 3.495 RF00177,RF01959,RF01960 URS000080DFED_300852 31501867 0003735 0005840 300852 guuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggcuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucaccuccuu ......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<.>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<........>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<...<<...<<<.....>>>.>>....>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............. ......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((..((((.))))..))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((.((...)).)))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((((..(((.(((....))).)))...((.(.....)))..))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...((((((......(((..(((.((((....))))).))....)))......))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}............ Dimeric E.coli YoeB bound to Thermus thermophilus 70S post-cleavage (UAA); 16S rRNA 6oxi QV 77 3.495 RF00005 URS000041AF00_562 31501867 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(((((.......)))))))))))..... Dimeric E.coli YoeB bound to Thermus thermophilus 70S post-cleavage (UAA); P-site tRNA-fMet 6oxi QX 18 3.495 31501867 562 caaggagguaaaaaugun .................. .................. Dimeric E.coli YoeB bound to Thermus thermophilus 70S post-cleavage (UAA); mRNA 6oxi RA 2891 3.495 RF02540,RF02541,RF00002 URS00001698E8_300852 31501867 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgggccggcccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu 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(((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...(((((((((..).))))))))....{.(((((((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).))))....(((((((((.[.....)))))))))....}.(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....(((.(.....))))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((.(.((((((......)))).)))..))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.........(((.(.(..(((.........)))..).).....(...((......)).).))).....)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.(((((.....))))).))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((...((((((((.(.........((((...(((......((((((((....)))))).))..))).............))))).))))))))...)))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....((((((..((..]]]]..)).)))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))...(((.....))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Dimeric E.coli YoeB bound to Thermus thermophilus 70S post-cleavage (UAA); 23S rRNA 6oxi RB 120 3.495 RF00001 URS000080E212_300852 31501867 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> (((((((((((....((((((((....((((((....(.....)....)))..)))...)))))).))(((.......((.(((((....))))).)).......))).))))))))))) Dimeric E.coli YoeB bound to Thermus thermophilus 70S post-cleavage (UAA); 5S rRNA 6oxi XA 1507 3.495 RF00177,RF01959,RF01960 URS000080DFED_300852 31501867 0003735 0005840 300852 guuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucaccuccuu ......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<..>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>....<<<.....>>>..>>>>>>>>.<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<...<<...<<<.....>>>.>>....>>>>>>.....<<<<<....>>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............. ......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((((((()))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(.(((....))).).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].]((((..(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((((..(((((((....)))))))...(.((.....)))..))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...((((((......(((..(((.((((....))))).))....)))......))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...))))))).)).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}............ Dimeric E.coli YoeB bound to Thermus thermophilus 70S post-cleavage (UAA); 16S rRNA 6oxi XV 77 3.495 RF00005 URS000041AF00_562 31501867 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Dimeric E.coli YoeB bound to Thermus thermophilus 70S post-cleavage (UAA); P-site tRNA-fMet 6oxi XX 18 3.495 31501867 562 caaggagguaaaaaugun .................. .................. Dimeric E.coli YoeB bound to Thermus thermophilus 70S post-cleavage (UAA); mRNA 6oxi YA 2878 3.495 RF02540,RF02541,RF00002 URS00001698E8_300852 31501867 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu 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(((.......(((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((...)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...(((((((((..).))))))))....{.(((((((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).))))....(((((((((.[.....)))))))))....}.(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))......(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((.(.((((((......)))).)))..))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((.(.....{.(((((.(((..(((.........)))..))).....(...((......)).).)))))...).)))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((.((((.((((.(.........(...(..(((......(((((.((....)).)))))...)))............)...)).)))).)))).))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....((((((..((..]]]]..)).)))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((.....))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Dimeric E.coli YoeB bound to Thermus thermophilus 70S post-cleavage (UAA); 23S rRNA 6oxi YB 120 3.495 RF00001 URS000080E212_300852 31501867 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> (((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).))))))))))) Dimeric E.coli YoeB bound to Thermus thermophilus 70S post-cleavage (UAA); 5S rRNA 6ozj C 15 2.247 31444105 32630 ciauaugcaugcauu ............... ............... Crystal structure of Mus musculus (Mm) Endonuclease V in complex with a 23mer RNA oligo containing an inosine in the absence of divalent cation; DNA/RNA (5'-R(P*CP*GP*GP*UP*AP*AP*CP*CP*C)-D(P*I)-R(P*AP*UP*AP*UP*GP*CP*AP*UP*GP*CP*AP*UP*U)-3') 6ozj D 15 2.247 31444105 32630 ciauaugcaugcauu ............... ............... Crystal structure of Mus musculus (Mm) Endonuclease V in complex with a 23mer RNA oligo containing an inosine in the absence of divalent cation; DNA/RNA (5'-R(P*CP*GP*GP*UP*AP*AP*CP*CP*C)-D(P*I)-R(P*AP*UP*AP*UP*GP*CP*AP*UP*GP*CP*AP*UP*U)-3') 6ozk C 15 2.104 31444105 32630 ciauaugcaugcauu ............... ............... Crystal structure of Mus musculus (Mm) Endonuclease V in complex with a 23mer RNA oligo containing an inosine after 68h soak in Ca2+; DNA/RNA (5'-R(P*CP*GP*GP*UP*AP*AP*CP*CP*C)-D(P*I)-R(P*AP*UP*AP*UP*GP*CP*AP*UP*GP*CP*AP*UP*U)-3') 6ozk D 15 2.104 31444105 32630 ciauaugcaugcauu ............... ............... Crystal structure of Mus musculus (Mm) Endonuclease V in complex with a 23mer RNA oligo containing an inosine after 68h soak in Ca2+; DNA/RNA (5'-R(P*CP*GP*GP*UP*AP*AP*CP*CP*C)-D(P*I)-R(P*AP*UP*AP*UP*GP*CP*AP*UP*GP*CP*AP*UP*U)-3') 6ozl C 15 2.1 31444105 32630 ciauaugcaugcauu ............... ............... Crystal structure of Mus musculus (Mm) Endonuclease V in complex with a 23mer RNA oligo containing an inosine after a 2 min soak in Mn2+; DNA/RNA (5'-R(P*CP*GP*GP*UP*AP*AP*CP*CP*C)-D(P*I)-R(P*AP*UP*AP*UP*GP*CP*AP*UP*GP*CP*AP*UP*U)-3') 6ozl D 16 2.1 31444105 32630 cciauaugcaugcauu ................ ................ Crystal structure of Mus musculus (Mm) Endonuclease V in complex with a 23mer RNA oligo containing an inosine after a 2 min soak in Mn2+; DNA/RNA (5'-R(P*CP*GP*GP*UP*AP*AP*CP*CP*C)-D(P*I)-R(P*AP*UP*AP*UP*GP*CP*AP*UP*GP*CP*AP*UP*U)-3') 6ozm C 15 2.15 31444105 32630 ciauaugcaugcauu ............... ............... Crystal structure of Mus musculus (Mm) Endonuclease V in complex with a 23mer RNA oligo containing an inosine after a 10 min soak in 10 mM Mn2+; DNA/RNA (5'-R(P*CP*GP*GP*UP*AP*AP*CP*CP*C)-D(P*I)-R(P*AP*UP*AP*UP*GP*CP*AP*UP*GP*CP*AP*UP*U)-3') 6ozm D 15 2.15 31444105 32630 ciauaugcaugcauu ............... ............... Crystal structure of Mus musculus (Mm) Endonuclease V in complex with a 23mer RNA oligo containing an inosine after a 10 min soak in 10 mM Mn2+; DNA/RNA (5'-R(P*CP*GP*GP*UP*AP*AP*CP*CP*C)-D(P*I)-R(P*AP*UP*AP*UP*GP*CP*AP*UP*GP*CP*AP*UP*U)-3') 6ozn C 15 1.9 31444105 32630 ciauaugcaugcauu ............... ............... Crystal structure of Mus musculus (Mm) Endonuclease V in complex with a 23mer RNA oligo containing an inosine after a 15 min soak in 10 mM Mn2+; DNA/RNA (5'-R(P*CP*GP*GP*UP*AP*AP*CP*CP*C)-D(P*I)-R(P*AP*UP*AP*UP*GP*CP*AP*UP*GP*CP*AP*UP*U)-3') 6ozn D 15 1.9 31444105 32630 ciauaugcaugcauu ............... ............... Crystal structure of Mus musculus (Mm) Endonuclease V in complex with a 23mer RNA oligo containing an inosine after a 15 min soak in 10 mM Mn2+; DNA/RNA (5'-R(P*CP*GP*GP*UP*AP*AP*CP*CP*C)-D(P*I)-R(P*AP*UP*AP*UP*GP*CP*AP*UP*GP*CP*AP*UP*U)-3') 6ozo C 23 2.235 31444105 32630 cgguaaccciauaugcaugcauu ....................... ....................... Crystal structure of Mus musculus (Mm) Endonuclease V in complex with a 23mer RNA oligo containing an inosine after a 30 min soak in 10 mM Mn2+; DNA/RNA (5'-R(*CP*GP*GP*UP*AP*AP*CP*CP*C)-D(P*I)-R(P*AP*UP*AP*UP*GP*CP*AP*UP*GP*CP*AP*UP*U)-3') 6ozo D 21 2.235 31444105 32630 guaaccciauaugcaugcauu ..................... ..................... Crystal structure of Mus musculus (Mm) Endonuclease V in complex with a 23mer RNA oligo containing an inosine after a 30 min soak in 10 mM Mn2+; DNA/RNA (5'-R(*CP*GP*GP*UP*AP*AP*CP*CP*C)-D(P*I)-R(P*AP*UP*AP*UP*GP*CP*AP*UP*GP*CP*AP*UP*U)-3') 6ozp C 12 1.96 URS000197CF4F_32630 31444105 32630 uaugcaugcauu ............ ............ Crystal structure of Mus musculus (Mm) Endonuclease V in complex with a 23mer RNA oligo containing an inosine after a 180 min soak in 10 mM Mn2+; RNA (5'-R(P*UP*AP*UP*GP*CP*AP*UP*GP*CP*AP*UP*U)-3') 6ozp D 12 1.96 URS000197CF4F_32630 31444105 32630 uaugcaugcauu ............ ............ Crystal structure of Mus musculus (Mm) Endonuclease V in complex with a 23mer RNA oligo containing an inosine after a 180 min soak in 10 mM Mn2+; RNA (5'-R(P*UP*AP*UP*GP*CP*AP*UP*GP*CP*AP*UP*U)-3') 6ozq C 15 2.153 31444105 32630 ciauaugcaugcauu ............... ............... Crystal structure of Mus musculus (Mm) Endonuclease V (K155M) in complex with a 23mer RNA oligo containing an inosine after a 100 min soak in 10 mM Mn2+ and K+; DNA/RNA (5'-R(P*CP*GP*GP*UP*AP*AP*CP*CP*C)-D(P*I)-R(P*AP*UP*AP*UP*GP*CP*AP*UP*GP*CP*AP*UP*U)-3') 6ozq D 15 2.153 31444105 32630 ciauaugcaugcauu ............... ............... Crystal structure of Mus musculus (Mm) Endonuclease V (K155M) in complex with a 23mer RNA oligo containing an inosine after a 100 min soak in 10 mM Mn2+ and K+; DNA/RNA (5'-R(P*CP*GP*GP*UP*AP*AP*CP*CP*C)-D(P*I)-R(P*AP*UP*AP*UP*GP*CP*AP*UP*GP*CP*AP*UP*U)-3') 6ozr C 15 2.15 31444105 32630 ciauaugcaugcauu ............... ............... Crystal structure of Mus musculus (Mm) Endonuclease V in complex with a 23mer RNA oligo containing an inosine after a 15 min soak in 10 mM Mg2+; DNA/RNA (23-MER) 6ozr D 15 2.15 31444105 32630 ciauaugcaugcauu ............... ............... Crystal structure of Mus musculus (Mm) Endonuclease V in complex with a 23mer RNA oligo containing an inosine after a 15 min soak in 10 mM Mg2+; DNA/RNA (23-MER) 6ozs C 12 2.41 URS000197CF4F_32630 31444105 32630 uaugcaugcauu ............ ............ Crystal structure of Mus musculus (Mm) Endonuclease V in complex with a 23mer RNA oligo containing an inosine after a 90 min soak in 10 mM Mg2+; RNA (5'-R(P*UP*AP*UP*GP*CP*AP*UP*GP*CP*AP*UP*U)-3') 6ozs D 12 2.41 URS000197CF4F_32630 31444105 32630 uaugcaugcauu ............ ............ Crystal structure of Mus musculus (Mm) Endonuclease V in complex with a 23mer RNA oligo containing an inosine after a 90 min soak in 10 mM Mg2+; RNA (5'-R(P*UP*AP*UP*GP*CP*AP*UP*GP*CP*AP*UP*U)-3') 6p4g 2 1697 3.1 RF01960,RF01959,RF00177 URS00005A14E2_9986 31609474 0003735 0005840 9986 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucgacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgcccggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcggccguccccugcucggcgccggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgaccccggucggcguaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggugcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<....<<....<<<<<........<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<<<....>>>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<<.>>>>>>>>.>>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....<<<<<<<<<.<<<....>>>..>>>>>>.>>>......<<..<...........>..>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<....<<<.<<<..>>>.>>><<<<<<<.<<..>>>>>>.>>>.<<<<<<.<.......<<...<.......>.<<<<.>>>>...>>......>.>>>..>>>........<.<<.<<<<<<<...............>>>>>>>.>>.>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<<....>>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<.......<<........>>..........<<<<<......<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<..>>>>.>>>>>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.......>>>>>....>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>............<<<<<..........>>>>>...........>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<.<<<<<<<<<..>>>>>>>>>...>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..((....(((......(...((.....((.(((.....))).))......))......)..((((...(((((......)))))...))))((..(((((...(......)..)))))......)).(.((((.(((...))))))))...)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).).....((((.((((.((......))..)))).).)))....(.((..(...........)..))......)..((((([[......((((.....((..]])).......)))).)))))..)))))).)))..[......(.([[...(.(.((...(((..(....(((.(.(())..)))).(.((((...()..))))..)..((((((.(.......((..((.......)).(((.)))....))......).)))..)))........(.((.((((((.................)))))).)).)....)....((((.(...(...((((..((..((((((((...((........))......))))))))..)).......((....))...))))..)...)..)))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.(((((....))))))))))).)..)))...((..]]))...))...].))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((..((........))..))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((...(...((((..((((((((((((..)))).))))))))..))))..).....((((.......))))........)))....))).))).....).))))).....).)))))...)).)))).))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..((((.((...((.((((...(.(((()))).)...).).)).))...)).))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}........ Structure of a mammalian small ribosomal subunit in complex with the Israeli Acute Paralysis Virus IRES (Class 1); 18S rRNA 6p4g 1 203 3.1 URS000197CF5E_294365 31609474 294365 caucauucuaugguuacccaucauuagaggaaauuuccaauaaacucugguguaaggcuuagagugauggucgaggugcccuauuuagggugaggagccucgguggcagccccaccaaauccucuauuggauaggaacagcuguacugggcaguuacagcagucguaugguaacacaugcggcguuccgaaauaccaugccug ..<<.<<<.............<<.<<<<.......((((......>>>>.>>.........>>>.>>......((((<<<<<....>>>>><<<<<)))).<<<<<.....>>>>>...>>>>>...))))..<<<<<.<<<<<<..(((((..>>>>>>.<<<<<<<..<...>.>>>>>>>>>>>>.........))))). .......(((...........(...((((......[[[......))))...).......)))..........(((((..(((....)))..[[[[[)))))(..((.....))..)...]]]]]....]]]..(((...((((((...[[[[..)))))).((((...(......)...))))..))).........]]]].. Structure of a mammalian small ribosomal subunit in complex with the Israeli Acute Paralysis Virus IRES (Class 1); IAPV-IRES 6p4h 2 1697 3.2 RF01960,RF01959,RF00177 URS00005A14E2_9986 31609474 0003735 0005840 9986 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucgacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgcccggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcggccguccccugcucggcgccggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgaccccggucggcguaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggugcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<....<<....<<<<<........<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<<<....>>>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<<.>>>>>>>>.>>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>...<<....>>.....>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....<<<<<<<<<.<<<....>>>..>>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<....<<<.<<<..>>>.>>>.<<<<<<.<<..>>>>>>.>>..<<<<<<.<.......<<...<.......>.<<<<.>>>>...>>......>.>>>..>>>........<.<<.<<<<<<<...............>>>>>>>.>>.>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>.>.>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<..>>>>.>>>>>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>............<<<<<..........>>>>>...........>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<.<<<<<<<<<..>>>>>>>>>...>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(....((....(((.....((...((.....((.(((.....))).))......))......)).((((...((((((....))))))...))))((..(((((...(......)..)))))......)).(.((((.(((...))))))))...)))...))..).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).).....(((((((((.((......))..)))))).)))....(.((..(...........)..))......)..((((([[......((((.....((..]])).......)))).)))))..)))))).)))..[......(.([[...(.(.((...(((..(....(((..((()))..))).((((((.((())))))).))..((((((.(.......((..((.......)).(((.)))....))......).)))..)))........(.((.(.((((.................)))).).)).)....)....((((.(...(...((((..((..((((((((...((........))......))))))))..)).......((....))...))))..)...)..)))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.(((((....))))))))))).)..)))...((..]]))...))...].))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((........((..((........))..))......)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((...(...((((..((((((((((((..)))).))))))))..))))..).....(((((.....)))))........)))....))).))).....).))))).....).)))))...)).)))).))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..((((.((...(((((((...(.(((..))).)...).).)))))...)).))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}........ Structure of a mammalian small ribosomal subunit in complex with the Israeli Acute Paralysis Virus IRES (Class 2); 18S rRNA 6p4h 1 203 3.2 URS000197CF5E_294365 31609474 294365 caucauucuaugguuacccaucauuagaggaaauuuccaauaaacucugguguaaggcuuagagugauggucgaggugcccuauuuagggugaggagccucgguggcagccccaccaaauccucuauuggauaggaacagcuguacugggcaguuacagcagucguaugguaacacaugcggcguuccgaaauaccaugccug ..<<<<<<<........<...<<<<<<<<......[[[......>>>>>>>>...>....>>>>>>>......((((.<<<<....>>>>.<<<<<)))).<<<<<.....>>>>>...>>>>>....]]]..<<<<..<<<<<<..(((((..>>>>>>.<<<<<<<<.<...>>>>>>>>>.>>>>.........))))). ..(...(((............(((.((((......[[[.[....)))).)))........)))...).....[.[[...(((....)))..(((((.]].].(.((.....))..)...)))))...]]]]..(((...(((.((..[[[[[..)).))).(.((..............).))..))).........]]]]]. Structure of a mammalian small ribosomal subunit in complex with the Israeli Acute Paralysis Virus IRES (Class 2); IAPV-IRES 6p5i 2 1697 3.1 RF01960,RF01959,RF00177 URS00005A14E2_9986 31609474 0003735 0005840 9986 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucgacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgcccggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcggccguccccugcucggcgccggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgaccccggucggcguaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggugcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<....<<....<<<<<........<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<<<....>>>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<<.>>>>>>>>.>>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<.[..>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....<<<<<<<<..<<<....>>>...>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.......].<.<((.....<.<<...<<<.<<.....<<.<<<..>>>.>>.<<<<<<<.<<..>>>>>>.>>>.<<<<<<.<.......<<...<.......>.<<<<.>>>>...>>......>.>>>..>>>..........<<.<<<<<<.................>>>>>>.>>......>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<......>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<........<<........>>..........<<<<<......<<<<<........<<..<<........>>..>>......>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<..>>>>.>>>>>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>>......>>>>>......>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>..........<.<<<<<..........>>>>>>..........>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<..<<<<<<<<..>>>>>>>>....>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(....((....((((....((...((.....((.(((.....))).))......))......)).((((...((((((....))))))...))))((..(((((...(......)..)))))......)).(.((((..(((.))).))))).).)))...))..).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).).....((((..(...(((....)))....)..).)))....(.((..(...........)..))......)..((((([[......((((.....((..]])).......)))).)))))..)))))).)))..[......(.([[...(.(.((...(((.((....((..(((..)))..)).(.((((..(()).))))..)..((((((.(.......((..((.......)).(((.)))....))......).)))..)))..........((.(.(((((...............))))).).))......))...(((..(...(...((((..(((.((((((((...((........))......)))))))).))).......((....))...))))..)...)...))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.(((((....))))))))))).)..)))...((..]]))...))...].))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........((((...(...((((.........(...((........))...).......))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((.......((((..(((((((((((....))).))))))))..))))........(((((.....)))))........)))....))).))).....).))))).....)..))))...)).)))).))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..((((.((...(((((...(((((((..))))))).....)))))...)).))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}........ Structure of a mammalian 80S ribosome in complex with the Israeli Acute Paralysis Virus IRES (Class 1); 18S rRNA 6p5i 1 205 3.1 URS000197CF5E_294365 31609474 294365 caucauucuaugguuacccaucauuagaggaaauuuccaauaaacucugguguaaggcuuagagugauggucgaggugcccuauuuagggugaggagccucgguggcagccccaccaaauccucuauuggauaggaacagcuguacugggcaguuacagcagucguaugguaacacaugcggcguuccgaaauaccaugccuggc ..<<<<<<<<...........<<<<<<<<......(((......>>>>>>>>.......>>>>>>>>.......(.(<<<<<....>>>>><<<<<).)..<<<<<.....>>>>>...>>>>>....)))..<<<<<.<<<<<<..(((((..>>>>>>.<<<<<<<<......>>>>>>>>>>>>>.........)))))... .(...(((((...........((..((((......[[[......))))..)).......)))))...).......[..((((....))))....((.]....((((.....))))....)).......]]]..(((((.((((((..[[[[[..)))))).(((((.((......)).)))))))))).........]]]]]... Structure of a mammalian 80S ribosome in complex with the Israeli Acute Paralysis Virus IRES (Class 1); IAPV-IRES 6p5i 5 3594 3.1 RF02540,RF02543 URS000197CF83_9986 31609474 0003735 0005840 9986 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggaaauguggcguacggaagacccacuccccggcgccggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugccggcggggcggaucucccgcucccgucggcgggggaccgccccccggccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcccgggggccccggguguuacagcccacccggcagcagcagcucgccgaaucccggggccgagggagcgagaccugugucgccgcgcucuccccccugggggggccgggccaccccucccacggcgcgaccgcuggggcggacuguccagugcgccccgggcgggucgcgccgucgggcccggggggccacgcgucccccgcgagcgcacggggucggcggcgaugucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcuacgaaagccgccguggcgcaaugaaggugaaggccggcgccgccggccgaggugggaucccgaggccuuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcgaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccaaaguuucccucaggauagcuggcgcucuccgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcugguguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggaugguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgcuggcagucggcagagcgagaaagagaguggcgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucagccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcuggcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacaugagagguguagaauaagugggaggcccgggccgccggugaaauaccacuacucugaucguuuuuucacugacccggugaggcgggggggcgagccgggcucucgcuucuggcgccaagcgcccggccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauagcgccggagccucgguuggccucggauagccggucccccgccgggguccggugcggagagcccuucgucccgggaaacggggcggccggaaagggggccgcccucucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcugcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>>..<<<<<<<<<....<<<<<<<<..<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>...>>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<......>>>..................................<<<<<<<<..<<<.<<...<<<<<<<..<<<.....<<<<<<<<<....<<<<<<<.<<<<<.<<<<<<<.<<<<<<<<........>>>>>>>>>>>>>>>>>>>>>>>>...>>>..>>>>>>>>>......>>>..>>.>>>>>...<<<<<<<<<<<<<<<<<<.<<<<...<<..<<<.....<<<......<<<<<<<<.>>>>>>>>.......>>>....>>>.........>>>>>>...>>>>>>>>>>.....<<.....{.>>......<<<<<..<<<<<<..>>>>>>....<<<...<<.<<<<<<<<<<<<<<<<<<<<<<<.<<<<..>>>>.>>>>>>>.>>.>>>>>>>>>>>.>>>...>>.>>.>...............>>>>>.....>>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<<<<...<<<<<<<<<<<<<<..<<<...<<<<.....>>>>.....>>>...<<....>>...<<<<<<.....>>>>>>..<<<<<...<<<..<<<....[[.[[.>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>>.<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<...<<<.<<<<<<<<<...<<<....<<<....<<<..<<<<.<.........>.>>>>>>>....>>>..>>.>...>>>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<......<..........<<<.<<<<<<<<<<........<<<<.<<....<<.........>>....>>.........<<......>>...>>>>....>>>>>>>>>>>>>..........))).>....>>>>>..>>>...>>>>>>><<<<<<.<<<........}...........]].]].............>>>>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<<<<.....>>>>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<..<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<<..............<<<<<....<....>.....>>>>><<.<<<<<<<<<<<.>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>....>>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<<<<<<.<<<<..........<<<.<..<<<<..>>>>............>.>>>.>>>>.>>.>>>>>>>>>>...<<<<<.....<<<<..<<...<<<>>.>..>>..............<<<<<<<<<..>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>><<<<....>>>>>>)))].....<<<<<<<..<<<..)))))).>>>>>>>>>>.........>>>>..>>>>>>.......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<.<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>..>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<.]]]..>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.<<<<<<...<<<<....<<<........<<<<<..<<<<<.>>>>>.>>>>>.......>>>...<<<..<<<<....<<....<.............>....>>...>>>>..>>>..............>>>>....>>>>>>.<<<<<.<.............>....<<.<<<<<<<.<<.....<<<<.<..<<<<<.>>>>>..>>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..(((((((((((.....)))))).))))....))))....(((((((((....((((((....((((((((..({((((......)))))....[[(...).(((....}]])))...).))))))).....))))))...)))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...(((((((..(((.....(((((((((....(((((((.(((((...(((((.((((..((.(.....)))..)))))))))..)))))))))...)))..)))))))))......)))..)).)))))...(((((((((((((((((((((((...((..(((....((((......((((((.....)))))).......))).)..))).........))))))..)))))))))))......(.....{{).......((((((.((((((()))))))...(.((..(((.(((((((((((.(..(..(.(((.(((....))).))).)...)...).)))))))).)))...))))).)..............)))))).....))).)))))...)))))...)))))))).[((((........))))((((((....(((((((((((((..(((..(((((.....))))..)..)))...((....))...((((.........))))..(((((...(((..(((....[[.[[[)))..)))....))))).(((((((((.((((......))))))))))).))....)))))))))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)<)))...(((..((.((.......B)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((...(((.((((((((....(((....(((..(.(((...(((((.........))))).))).)..)))..)).)....))))))...(((((((((.(......))))))))))....))))))))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.....A..((((.(.(...((.........))...).).....(...((......)).).))))....)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((.......}}.........].]].]].............)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...((....(((....)))..........((.((((((.(.....).))))))))......))....))...(((((........)))))]]((((....(((((...((.(..(....)..).))..((((....)))...(...((((((...(((((((((((((((((((((((...{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((.)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.(((((((((.(((((((.(.((.(((........[..(((((..(..(())..)..........].)))))..))).))..).)))))))...(((((.....((((..(..(..(...)..).)..............((((((.((())).))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..b.))..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}..)))))..)).))...))))...)))).((((...((((.....a.......))))...))))..)))...).)))))).(((((((..((((.(..(((.........((((..((((...)))).))))........)))...(((..(((.....((....(.............)....))....)))..)))...........)..))))..).)))))).(((((.(..(.......)..)....((.(((((((.((.....((((.(..(((((.)))))..)))))....))....)))).))).))..))))).. Structure of a mammalian 80S ribosome in complex with the Israeli Acute Paralysis Virus IRES (Class 1); 28S rRNA 6p5i 7 119 3.1 RF00001 URS000064027A_9986 31609474 0003735 0005840 9986 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>. ((((((.((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....)))))))).)))))). Structure of a mammalian 80S ribosome in complex with the Israeli Acute Paralysis Virus IRES (Class 1); 5S rRNA 6p5i 8 151 3.1 RF00002 URS00004B2C76_9986 31609474 0003735 0005840 9986 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcagguugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<<<<....>>>>.....<.<<<......>>........>>>..>...>>>....<<<..>>><<<<<<<<.......>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]]........)))..)...)))....((....))((((((((.......)))))))).................... Structure of a mammalian 80S ribosome in complex with the Israeli Acute Paralysis Virus IRES (Class 1); 5.8S rRNA 6p5j 2 1697 3.1 RF01960,RF01959,RF00177 URS00005A14E2_9986 31609474 0003735 0005840 9986 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucgacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgcccggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcggccguccccugcucggcgccggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgaccccggucggcguaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggugcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<.........<<<..<<........<.....<............>....>.........<<........<<<.<....<<....<<<<<........<<..<..<<.<<.......>>.>>.....>>>.........<<<<...<<<<<<....>>>>>>...>>>><....<<<<...<......>..>>>>........>....<<...<.<.>.>..>>..>>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>.>>>.........<<<.....<<<...>>>...>>>......>>.>.....<<<.<<<<..<<<....>>>...>>>>..>>>......<...................>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<........<<.<<<..>>>.>>.<.<<<<<.<<..>>>>>>.>.>.<<<<<<.<........<...<.......>.<<<<.>>>>...>.......>.>>>..>>>..........<<.<<<<<<<...............>>>>>>>.>>............<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<......<<<<.............<<........>>...........>>>>...<..<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<....>>>.>>>>>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>.>.......>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>..........<.<<<<<..........>>>>>>..........>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<..<<<<<<<<<..>>>>>>>>>....>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..((.....(((...(..(...........((..........)).......)......(((.......(((...(..((....(((((........((.....(....(......)...)......)).........((((....((.(......).))....))))....((..(...(......)..)..)).........(...(...(((.)))..)..))).)))...)))...))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)..))).).....(.......(.((......)).)...).)...)).).....((...(....(........).....)....))....(.....(...........)..........)..((((([[......((((.....((..]])).......)))).)))))..)))))).)))..[......(.([[...(.(.((...(((........................(..(((.......)))...)..((((((.(........(..............(((.)))....).......).)))..)))........(.(..((((((.................))))))..)...).......(((.(((..(...(((...((..((((((((...((........))......))))))))..)).......((....))....)))..)..))..)))..))))...)).)....((((((........((((.........)))).....))))))......{...(((.((.(((..(.((((((.((((......)))))))))).)..)))...((..]]))...))...].))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((..(((((......((........))..........(((((......((((.............((........))...........))))...((.((....(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((...(...(((...(((((((.((......))..)))))))...)))..).....(((((.....)))))........)))....))).))).....)..)))).......)))))...)).)))..))).(...(..((.........(.......((..(..(....)..)..)).....).........))..)......(.....(((((..........))))).....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..((((.((...(((((..(.(((........)))..)...)))))...)).))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}........ Structure of a mammalian 80S ribosome in complex with the Israeli Acute Paralysis Virus IRES (Class 2); 18S rRNA 6p5j 1 205 3.1 URS000197CF5E_294365 31609474 294365 caucauucuaugguuacccaucauuagaggaaauuuccaauaaacucugguguaaggcuuagagugauggucgaggugcccuauuuagggugaggagccucgguggcagccccaccaaauccucuauuggauaggaacagcuguacugggcaguuacagcagucguaugguaacacaugcggcguuccgaaauaccaugccuggc ..<<<<<<<<.<.....<...<<<<<<<<......(((.[....>>>>>>>>...>..>>>>>>>>>.......(((<<<<<....>>>>><<<<.)))..<<<<<.....>>>>>....>>>>..].)))..<<<<..<<<<<<..(((((..>>>>>>.<<<<<<<<......>>>>>>>>.>>>>.........)))))... .(..((..((.......(...(((..((.......[[..[[....))..)))...)...))..))..).......[..((((....))))....((.].....(((.....))).....).)...].].]]..(((...((((((..[[[[[..))))))..(((((((......)))))))...))).........]]]]]... Structure of a mammalian 80S ribosome in complex with the Israeli Acute Paralysis Virus IRES (Class 2); IAPV-IRES 6p5j 5 3594 3.1 RF02540,RF02543 URS000197CF83_9986 31609474 0003735 0005840 9986 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggaaauguggcguacggaagacccacuccccggcgccggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugccggcggggcggaucucccgcucccgucggcgggggaccgccccccggccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcccgggggccccggguguuacagcccacccggcagcagcagcucgccgaaucccggggccgagggagcgagaccugugucgccgcgcucuccccccugggggggccgggccaccccucccacggcgcgaccgcuggggcggacuguccagugcgccccgggcgggucgcgccgucgggcccggggggccacgcgucccccgcgagcgcacggggucggcggcgaugucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcuacgaaagccgccguggcgcaaugaaggugaaggccggcgccgccggccgaggugggaucccgaggccuuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcgaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccaaaguuucccucaggauagcuggcgcucuccgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcugguguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggaugguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgcuggcagucggcagagcgagaaagagaguggcgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucagccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcuggcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacaugagagguguagaauaagugggaggcccgggccgccggugaaauaccacuacucugaucguuuuuucacugacccggugaggcgggggggcgagccgggcucucgcuucuggcgccaagcgcccggccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauagcgccggagccucgguuggccucggauagccggucccccgccgggguccggugcggagagcccuucgucccgggaaacggggcggccggaaagggggccgcccucucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcugcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>>..<<<<<<<<<....<<<<<<<.<.<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>...>>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<.<....<<<<<<<..<<<.....<<<<<<<<<....<<<<<<<.<<<<<.<<<<<<<.<<<<<<<.<.......>>>>>>>>>>>>>>>>>>>>>>>>...>>>..>>>>>>>>>......>>>..>>.>>>>>...<<<<<<<.<<<<<<<<<<.<<<<...<<..<<<.....<<<......<<<<<<.....>>>>>>.......>>>....>>>.........>>>>>>...>>>>>>>>>>.....<<.....<.>>......<<<<<<.<<<<<<..>>>>>>...<.<....<<.<<<<<<<<<<<<<<<<<<<<<<<.<<<<..>>>>.>>>>>>>.>>>.>>>>>>>>>>.>>>...>>..>.>..............>>>>>>......>>.>>>>>....>>>>...>>>>>>>>..<<<<........>>>><<<<<<...<<<<<<<<<<<<<<..<<<...<<<<.....>>>>.....>>>...<<....>>...<<<<<<.....>>>>>>..<<<<<...<<<..<<<....[[.[[.>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>>.<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<...<<<.<<<<<<<<<...<<<....<<<....<<<..<<<<.<.........>.>>>>>>>....>>>..>>.>...>>>>>>>...<<<<<<<<<.........>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<......<..........<<<.<<<<<<<<<<........<<<<.<<....<<.........>>....>>.........<<......>>...>>>>....>>>>>>>>>>>>>..........))).>....>>>>>..>>>...>>>>>>><<<<<<.<<<........>...........]].]].............>>>>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<<<<.....>>>>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<..<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<<........<.....<<<<<...............>>>>><<.<<<<<<<<<<<.>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>.>>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<..<<<<<<<<<.<<<<<<<<<<<<.<<<<..........<<<.<..<<<<..>>>>............>.>>>.>>>>.>>.>>>>>>>>>>...<<<<<.....<<<<...<.<..<<>>..>.>...............<<<<<<<<<..>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>...>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>>.<<<....>>>.>>)))].....<<<<<<<..<<<..)))))).>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<.]]]..>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.<<<<<<<..<<<<....<<<........<<<<<...<<<<.>>>>..>>>>>.......>>>...<<<..<<<<....<<<<..<<<........>>.>..>>>>...>>>>..>>>..............>>>>..>.>>>>>>.<<<<<.<.............>....<<.<<<<<<<.<<.....<<<<.<..<<<<<.>>>>>..>>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..(((((((((((.....)))))).))))....))))....(((((((((....(((.((..(.((((((((..({((((......)))))....[[(...).(((....}]])))...).)))))))...).)).)))...)))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....(((((((((.(..(((((((.(((((...(((((.((.(((..((.....)).))).)))))))..)))))))))...)))).)))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((.......(.......((((.......))))........)......))).........))))))..))))))))))).....((.....{{))......((((((.((((((..))))))...(.((..(.(.((((((((((.(......(((((.(((....))).)))))........).))))))).)))...).).)))..............)))))).....))).)))))...)))))...)))))))).[((((........))))((((((....(((((((((((((..(((..(((((.....))))..)..)))...((....)).....(((.......)))....(((((...(((..(((....[[.[[[)))..)))....))))).(((((((((.((((......))))))))))).))....)))))))))))))..((.(...((((((.....(((((((((..((((...((((((......))))))...)<)))...(((..((.((.......A)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((...(((.((((((((....(((....(((..(.(((..(.(((...........))).)))).)..)))..)).)....))))))...(((((((((.(......))))))))))....))))))))))))..))..((((.((.((.....)).)).))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((..............((...................))..........(........)...........)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((.......}}.........].]].]].............)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...((..(.(((....))).....).........(((((((...)))))))..........))....))...(((((........)))))]]((((....(((((...((.((((....)))).))..((((....)))...(...((((((...(((((((((((((((((((((((...{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((.(((((.)))))...))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.....((.....((((....)))).....))..))))..)))))(.(((.........))).)........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.(((((((((.(((((((.((....(............(..(...(..(..)..).............)..)....)....)).)))))))...(((((.....((((.......((...))..................(((((((......)))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a.))..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}..)))))..)).))...))))...)))).((((...((((.............))))...))))..)))...).))))))...(((.(..((((....(((.........((((....(((.)))...))))........)))...(((..(((.....((.((.(.............)))..))....)))..)))..............))))..)..)))...(((((.(..(.......)..).....(.(((((((.((.....((((.(..(((((.)))))..)))))....))....)))).))).)...))))).. Structure of a mammalian 80S ribosome in complex with the Israeli Acute Paralysis Virus IRES (Class 2); 28S rRNA 6p5j 7 119 3.1 RF00001 URS000064027A_9986 31609474 0003735 0005840 9986 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcu <<<<<<<<<....<<<<<<<<.....<<<<<.....<.....>..>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))). Structure of a mammalian 80S ribosome in complex with the Israeli Acute Paralysis Virus IRES (Class 2); 5S rRNA 6p5j 8 151 3.1 RF00002 URS00004B2C76_9986 31609474 0003735 0005840 9986 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcagguugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<.<<.....>>>.....(.<<<......>>........>>>..)...>>>....<<<..>>><<<<<<<<.......>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]]........)))..)...)))....((....))((((((((.......)))))))).................... Structure of a mammalian 80S ribosome in complex with the Israeli Acute Paralysis Virus IRES (Class 2); 5.8S rRNA 6p5k 5 3594 3.1 RF02540,RF02543 URS000197CF83_9986 31609474 0003735 0005840 9986 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggaaauguggcguacggaagacccacuccccggcgccggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugccggcggggcggaucucccgcucccgucggcgggggaccgccccccggccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcccgggggccccggguguuacagcccacccggcagcagcagcucgccgaaucccggggccgagggagcgagaccugugucgccgcgcucuccccccugggggggccgggccaccccucccacggcgcgaccgcuggggcggacuguccagugcgccccgggcgggucgcgccgucgggcccggggggccacgcgucccccgcgagcgcacggggucggcggcgaugucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcuacgaaagccgccguggcgcaaugaaggugaaggccggcgccgccggccgaggugggaucccgaggccuuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcgaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccaaaguuucccucaggauagcuggcgcucuccgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcugguguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggaugguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgcuggcagucggcagagcgagaaagagaguggcgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucagccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcuggcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacaugagagguguagaauaagugggaggcccgggccgccggugaaauaccacuacucugaucguuuuuucacugacccggugaggcgggggggcgagccgggcucucgcuucuggcgccaagcgcccggccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauagcgccggagccucgguuggccucggauagccggucccccgccgggguccggugcggagagcccuucgucccgggaaacggggcggccggaaagggggccgcccucucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcugcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>>..<<<<<<<<<....<<<<<<<.<<<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>..>>>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<......>>>..................................<<<<<<<<..<<<.<....<<<<<<<<.<<<.....<<<<<<<<<....<<<<<<<.<<<<<.<<<<<<<.<<<<<<<<<......>>>>>>>>>>>>>>>>>>>>>>>>>...>>>..>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<<<<<<<<<<<<.<<<<...<<..<<<.....<<<......<<<<<<<...>>>>>>>.......>>>....>>>.........>>>>>>...>>>>>>>>>>.....<<.....{.>>......<<<<<<.<<<<<<..>>>>>>...<.<<..<<<.<<<<<<<<<<<<<<<<<<<<<<<.<<<<..>>>>.>>>>>>>.>>>.>>>>>>>>>>.>>>...>>>>>.>..............>>>>>>.....>>>.>>>>>....>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<.....>>>>.....>>>...<<....>>...<<<<<<.....>>>>>>..<<<<<...<<<..<<<....[[.[[.>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<...<<<.<<<<<<<<<...<<<....<<...<.<<<<..<<<.<.........>.>>>>>>>.>...>>..>.>>...>>>>>>>...<<<<<<<<<.........>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<......<..........<<<.<<<<<<<<<<........<<<<.<.....<<.........>>.....>.........<<......>>...>>>>....>>>>>>>>>>>>>..........))).>....>>>>>..>>>...>>>>>>><<<<<<.<<<........}...........]].]].............>>>>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<.<<<...>>>.>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<...<<<<<<<....>>>>>>>...<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<<........<.....<<<<<...............>>>>><<.<<<<<<<<<<<.>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<....<<<<<....>>>>.>...>>>.>>>>..>>>>>..<<<<.......>>>>..........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>.>>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<<<<.<.<<<<..........<<<.<..<<<<..>>>>............>.>>>.>>>>.>..>>>>>>>>>>...<<<<<.....<<<<..<<.<<<.....>>>>>..............<<<<<<<<<..>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>>.<<<....>>>.>>)))].....<<<<<<<..<<<..)))))).>>>>>>>>>>.........>>>>..>>>>>>.......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<.<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>..>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<...<<<.<<<<<<<]]].>>>>>..>>.>>>..>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.<<<<<<...<<<<....<<<........<<<<<..<<<<<.>>>>>.>>>>>.......>>>...<<<..<<<<....<<<<..<.............>..>>>>...>>>>..>>>..............>>>>....>>>>>>.<<<<<.<.............>....<<.<<<<<<<.<<.....<<<<.<..<<<<<.>>>>>..>>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..(((((((((((.....)))))).))))....))))....(((((((((....(((.(((.(.((((((((...{((((......)))).....[[(...).(((....}]])))...).)))))))...)))).)))...)))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....(((((((((.(..(((((((.(((((.(.(((((.(((((...((.....))..)))))))))).))))))))))...)))).)))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((....(.((......((((((((.)))))))).......))..)..))).........))))))..)))))))))))......(.....{{).......((((((.((((((()))))))...(.((..(((.(((((((((((((.....((((..(((....)))..)))).......)))))))))).)))...))))).)..............)))))).....))).)))))...)))))...)))))))).[((((........))))((((((....(((((((((((((..(((..(((((.....))))..)..)))...((....))...(((((((...)))))))..(((((...(((..(((....[[.[[[)))..)))....))))).(((((((((.((((......))))))))))).))....)))))))))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((...(((.((((((((....(((....(((..(.(((..((..((..........)).))))).)..)))..)).)....))))))...(((((((((.(......))))))))))....))))))))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((........((((.(.......................)......................))))....)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((.......}}.........].]].]].............)))))))))....))))))...((((((((.((......((((.((((....))))))))...))))))))))........))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...((..(.(((....))).....)....((.((((.((.......)).))))))......))....))...(((((........)))))]]((((....(((((...(((((.(....).)))))..((((....)))...(...((((((...(((((((((((((((((((((((...{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((.....)))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.....((.....((((....)))).....))..))))..)))))..(((.........)))..........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.(((((((((.(((((((.(.((.(((...........(.(....(.((())).)..............).)..))).))..).)))))))...(((((.....((((..(..(.((..).).).)..............((((((........))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a.))..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}..)))))..)).))...))))...)))).((((...((((.............))))...))))..)))...).)))))).((((((...((((....(((.........((((.(.(((...)))).))))........)))...(((..(((.....((.......................).)...)))..)))..............))))....)))))).(((((.(..(.......)..)....((.(((((((.((.....((((.(..(((.(.).)))..)))))....))....)))).))).))..))))).. Structure of a mammalian 80S ribosome in complex with the Israeli Acute Paralysis Virus IRES (Class 3); 28S rRNA 6p5k 7 119 3.1 RF00001 URS000064027A_9986 31609474 0003735 0005840 9986 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))). Structure of a mammalian 80S ribosome in complex with the Israeli Acute Paralysis Virus IRES (Class 3); 5S rRNA 6p5k 8 151 3.1 RF00002 URS00004B2C76_9986 31609474 0003735 0005840 9986 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcagguugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<.<<.....>>>.....(.<<<......>>........>>>..)...>>>....<<<..>>><<<<<<<<.......>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]]........)))..)...)))....((....))((((((((.......)))))))).................... Structure of a mammalian 80S ribosome in complex with the Israeli Acute Paralysis Virus IRES (Class 3); 5.8S rRNA 6p5k 2 1697 3.1 RF01960,RF01959,RF00177 URS00005A14E2_9986 31609474 0003735 0005840 9986 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucgacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgcccggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcggccguccccugcucggcgccggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgaccccggucggcguaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggugcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<....<<....<<<<<........<<.....<<.<<.......>>.>>......>>.........<<<<...<<<<<<....>>>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<...>>>>>>>.>>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>...<<....>>.....>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....<<<.<<<.<.<<<....>>>..>.>>>..>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<.....<<.<<<..>>>.>>.<<<<<<<.<<..>>>>>>.>>>.<<<<<<.<.......<<...<.......>.<<<<.>>>>...>>......>.>>>..>>>..........<<.<<<<<<<...............>>>>>>>.>>......>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>.>.>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<......>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<........<<........>>..........<<<<<......<<<<<........<<..<<........>>..>>......>>>>>...<..<<...<<.<<<<<<....<<<.<<<<......>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<..>>>>.>>>>>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>.>>.>.......>>>>>......>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<.<<<<<<<<<..>>>>>>>>>...>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..((....((((....((...((.....((.(((.....))).))......))......)).((((...((((.(....).))))...))))((..(((((...(......)..)))))......)).(.((((.(((...)))))))).).)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).).....((...((.(.(((....)))...)))....))....(.....(...........)..........)..((((([[......((((.....((..]])).......)))).)))))..)))))).)))..[......(.([[...(.(.((...(((..(....(...((....))...)...(.((.......)).).....((((((.(.......((..((.......)).(((.)))....))......).)))..)))..........((.((.((((...............)))).)).))......)....(((.((...(...((((..(((.((((((((...((........))......)))))))).))).......((....))...))))..)...))..))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.(((((....))))))))))).)..)))...((..]]))...))...].))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((......(((((.....(..(...((........))...)....).)))))...((.((....(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((.......(.((..(((((((((((....))).))))))))..)).).........((((.....)))).........)))....))).))).....)..)))).......)))))...)).)))).))).(...((.(((........(.......((..((((....))))..))....).........))).))......(.....(((((..........))))).....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(.((((((.(.(((..((((.((...((((((.(((.((((..)))).)))..).)))))...)).))))..))).).)))))))..)).))))...).))...)..)..(((((((((....)))))))))}........ Structure of a mammalian 80S ribosome in complex with the Israeli Acute Paralysis Virus IRES (Class 3); 18S rRNA 6p5k 1 205 3.1 URS000197CF5E_294365 31609474 294365 caucauucuaugguuacccaucauuagaggaaauuuccaauaaacucugguguaaggcuuagagugauggucgaggugcccuauuuagggugaggagccucgguggcagccccaccaaauccucuauuggauaggaacagcuguacugggcaguuacagcagucguaugguaacacaugcggcguuccgaaauaccaugccuggc ..<<<<<<<<...........<<<<<<<<......(((.(....>>>>>>>>.......>>>>>>>>.......<.<<<<<<....>>>>>..((.>.>..<<<<<.....>>>>>....).)...).)))..<<<<<.<<<<<<..((((...>>>>>>..<<<<<<<.<...>>>>>>>>.>>>>>..........))))... ....(((((............((.((..(.......[[.[....)..)).))........)))))..........[[..(((....)))..((.((]]....((((.....))))....)).))...]]]...(((((.((((((..[[[[[..)))))).(((((((........)))))))))))).........]]]]]... Structure of a mammalian 80S ribosome in complex with the Israeli Acute Paralysis Virus IRES (Class 3); IAPV-IRES 6p5n 5 3594 3.2 RF02540,RF02543 URS000197CF83_9986 31609474 0003735 0005840 9986 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggaaauguggcguacggaagacccacuccccggcgccggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugccggcggggcggaucucccgcucccgucggcgggggaccgccccccggccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcccgggggccccggguguuacagcccacccggcagcagcagcucgccgaaucccggggccgagggagcgagaccugugucgccgcgcucuccccccugggggggccgggccaccccucccacggcgcgaccgcuggggcggacuguccagugcgccccgggcgggucgcgccgucgggcccggggggccacgcgucccccgcgagcgcacggggucggcggcgaugucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcuacgaaagccgccguggcgcaaugaaggugaaggccggcgccgccggccgaggugggaucccgaggccuuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcgaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccaaaguuucccucaggauagcuggcgcucuccgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcugguguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggaugguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgcuggcagucggcagagcgagaaagagaguggcgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucagccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcuggcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacaugagagguguagaauaagugggaggcccgggccgccggugaaauaccacuacucugaucguuuuuucacugacccggugaggcgggggggcgagccgggcucucgcuucuggcgccaagcgcccggccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauagcgccggagccucgguuggccucggauagccggucccccgccgggguccggugcggagagcccuucgucccgggaaacggggcggccggaaagggggccgcccucucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcugcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>>..<<<<<<<<<....<<<<<<<<..<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>...>>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<.<....<<<<<<<<.<<<.....<<<<<<<<<....<<<<<<<.<<<<<.<<<<<<<.<<<<<<<.<<.....>>>>>>>>>>>>>>>>>>>>>>>>>...>>>..>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<.<<<<<<<<<<<<<<<...<<..<<..<<..<<<......<<<<<<<..>.>>>>>>.......>>>..>>.>>.........>>>>>>..>>>>>>>>>>>.....<<.....<.>>......<<<<<<.<<<<<<..>>>>>>...<.<<..<<<.<<<<<<<<<<<<<<<<<<<<<<<.<<<<..>>>>.>>>>>>.>>>.>>>>>>>>>>>.>>>...>>>.>>>..............>>>>>>......>>.>>>>>....>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<.......>>>.....>>>...<<....>>...<<<<<<<...>>>>>>>..<<<<<...<<<..<<<....[[.[..>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<...<<<.<<<<<<<<<...<<<....<<<..<.<<<<..<<<.<.........>.>>>>>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<..........<<.<<....<<.........>>....>>.........<<......>>...>>......>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<........>............].]].............>>>>>>>>>....>>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<<....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....(.<<<<<<...<<....<<<....>>>..........<<.<<<<<.<<<...>>>.>>>>>>>......>>....>>>..<<<<<........>>>>>.)<<<<....<<<<<..<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<.>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>>.<<<<<.......>>>>>.........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>...>>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<<<<<<.<<<<..........<<<.....<<<..>>>...............>>>.>>>>.>>.>>>>>>>>>>...<<<<<.....<<<<...<....<<>>....>...............<<<<<<<<<..>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>>.<<<....>>>.>>)))].....<<<<<<<..<<<..)))))).>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<]]].>>>>>..>>.>>...>>>>...>>>><<<<....<<<<<...........>>>>>....>>>>.>>>...>.>>>>>>.<<<<<<<..<<<<....<<<........<<<<<.<.<<<<.>>>>>.>>>>>.......>>>...<<<..<<<<....<<....<.............>....>>...>>>>..>>>..............>>>>..>.>>>>>>.<<<<<.<.............>....<<.<<<<<<<.<<.....<<<<.<..<<<<<.>>>>>..>>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..((((((((((.......))))).))))....))))....(((((((((....(((.((..(.((((((((..({((((......)))))....[[(...).(((....}]])))...).)))))))...).)).)))...)))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....(((((((((.(..(((((((.(((((.(((((((.((((((...(.....)..))))))))))))))))))))))...)))).)))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((.((.((.(......(((((.......)))))........)).)))))).........))))))..))))))))))).....((.....{{))......((((((.((((((..))))))...(.((..(((.((((((((((.(.((...(((((...(....)...)))))....))..).))))))).)))...))).)))..............)))))).....))).)))))...)))))...)))))))).[((((........))))((((((....(((((((((((((..(((..(((((.....))))..)..)))...((....))...((((((.....))))))..(((((...(((..(((....[[.[.[)))..)))....))))).(((((((((.((((......))))))))))).))....)))))))))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((...(((.((((((((....(((....(((..(.(((..(((((...........)))))))).)..)))..)).)....))))))...(((((((((.(......))))))))))....))))))))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((...........(..(....((.........))....)......(..............).).......)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((.......}}...........]].]].............)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...((..(.(((....))).....).......(.((..((.....))..)).)........))....))...(((((........)))))]]((((....(((((...((.((((....)))).))..((((....)))...(...((((((...(((((((((((((((((.(((((...{{..))))).....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((.)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.(((((((((.(((((.(.((...((...............(...((.(..).)).............)......))....)).).)))))...(((((.....((((.....(..(...)..)................(((((((......)))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a.))..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}..)))))..)).))...))))...)))).(((....((((.............))))....)))..)))...).))))))...(((.(..((((....(((.........((((....((...))...))))........)))...(((..(((.....((..(.(.............))...))....)))..)))..............))))..)..)))...(((((.(..(.......)..)....((.(((((((.((.....((((.(..(((((.)))))..)))))....))....)))).))).))..))))).. Structure of a mammalian 80S ribosome in complex with a single translocated Israeli Acute Paralysis Virus IRES and eRF1; 28S rRNA 6p5n 7 119 3.2 RF00001 URS000064027A_9986 31609474 0003735 0005840 9986 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))). Structure of a mammalian 80S ribosome in complex with a single translocated Israeli Acute Paralysis Virus IRES and eRF1; 5S rRNA 6p5n 8 151 3.2 RF00002 URS00004B2C76_9986 31609474 0003735 0005840 9986 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcagguugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<.<<.....>>>.....(.<<<......>>........>>>..)...>>>....<<<..>>><<<<<<<<.......>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]]........)))..)...)))....((....))((((((((.......)))))))).................... Structure of a mammalian 80S ribosome in complex with a single translocated Israeli Acute Paralysis Virus IRES and eRF1; 5.8S rRNA 6p5n 2 1697 3.2 RF01960,RF01959,RF00177 URS00005A14E2_9986 31609474 0003735 0005840 9986 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucgacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgcccggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcggccguccccugcucggcgccggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgaccccggucggcguaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggugcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<...<....<<....<<..........>>...>>.>.......<<........<<<.<....<<....<<<<<........<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<<<....>>>>>>...>>>>...<<..<....<......>...>.>>...........<<<<.<<<<.>>>>>>>>.>>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....<<<.<<<...<<<....>>>....>>>..>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<......<.<<<..>>>..>.<<.<<<<.<<..>>>>>>..>>.<<<<<<.<.......<<...<.......>.<<<<.>>>>...>>......>.>>>..>>>..........<<.<<<<<<<...............>>>>>>>.>>......>>....<<<<<<......<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>.>.>>.......<<....>>...>>>>.....>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<........<<........>>..........<<<<<.<....<.<..........<...<<........>>...>........>.>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<.......<<<<..<<<<<<<<<<<....>>>.>>>>>>>>..>>>>........<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.....>.>>>>>......>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<.<<<<<<<<....>>>>>>>>...>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..((....((((.........(.(....((.(((.....))).))......)).........((((...(((..........)))...))))(..((.((....(......)...)))).......).(.((((.(((...)))))))).).)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).).....(((..((....((....)).....))...)))....(.((..(...........)..))......)..((((([[......((((.....((..]])).......)))).)))))..)))))).)))..[......(.([[...(.(.((...(((..(......(.(.......).)..((((((.......)))).))..((((((.(.......((...(.......)..((.()))....))......).)))..)))........(.((.((((((.................)))))).)).)....)....(((.(((..(...((((..(((.((((((((...((........))......)))))))).))).......((....))...))))..)..)))..))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.((((......)))))))))).)..)))...((..]]))...))...].))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((.(..(((.((((((......((........))..........((.((.(....(.........(......(..........)........).....)...((.(((...(.((((((.(..(((.(((((....)))..(.((......)))...)).)))....(((...(.....((..(((((((((((....))).))))))))..))....).....(((((.....)))))........))).)..))).))).....).))))).....).)).))...)).)))).))).(...((.(((........(.......((..((((....))))..))....).........))).))......(.....(((((..........))))).....)..)..).))).....((.(((((.......))))).))......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..((((.((...(((((..((.(.(.......).)))....)))))...)).))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}........ Structure of a mammalian 80S ribosome in complex with a single translocated Israeli Acute Paralysis Virus IRES and eRF1; 18S rRNA 6p5n 1 207 3.2 URS000197CF61_294365 31609474 294365 caucauucuaugguuacccaucauuagaggaaauuuccaauaaacucugguguaaggcuuagagugauggucgaggugcccuauuuagggugaggagccucgguggcagccccaccaaauccucuauuggauaggaacagcuguacugggcaguuacagcagucguaugguaacacaugcggcguuccgaaauaccaugccuugaua .<<<<<<<<<........<..<<<<<<<<........(......>>>>>>>>...>...>>>>>>>>>......(.(<<<<<....>>>>>.<<<<)..).<<<<<.....>>>>>...>>>>......)...<<<<<.<<<<<<..((((...>>>>>>.<<<<<<<<......>>>>>>>>>>>>>..........))))..... .(.(..((((...........(((.((((........[......)))).))).......))))..).).....(.((.((((....))))....[[)).)..((((.....))))....].].......]...(((...((((.(..[[[[..)..)))).((((((((......))))))))..)))..........]]]]..... Structure of a mammalian 80S ribosome in complex with a single translocated Israeli Acute Paralysis Virus IRES and eRF1; IAPV-IRES 6pc5 I 2897 2.7 RF02540,RF02541 URS00004B0F34_562 32968273 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccuu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<....<<.........>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<....<<<.......>>>....>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<......>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>.>........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>..>.....>>>>>>>>..>>>>><<<<<.........>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<.......>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<..<<<.<<<<<.<<<<<<<<.<....<.............<.<<.................................................>>.>...>.....>.>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>...>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>.. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((.(......).))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(.(.........))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.((((.((.....((.........))......)........(........)...)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((.(......).))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))((((...........))))........((.(......).(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((.....(.............(.......................................................)....).....)))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).).....((.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..))....(.(((((....))).)).)....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))).. E. coli 50S ribosome bound to compounds 46 and VS1; 23S ribosomal RNA 6pc5 J 118 2.7 RF00001 URS0000366A67_562 32968273 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (((((((((.....((.(((((....(((((((...(.....)...))))..)))...)))))..)).((.......((((((((...)))))))).......))...))))))))). E. coli 50S ribosome bound to compounds 46 and VS1; 5S ribosomal RNA 6pc6 I 2897 2.5 RF02540,RF02541 URS00004B0F34_562 32968273 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccuu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<....<<.........>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<.....<<.........>>.....>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<......>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>.>........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>..>.....>>>>>>>>..>>>>><<<<<.........>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<.......>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<.<<...<............<<<<<.................................................>>>>>..>....>>.>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>.. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((.(......).))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(.(.........))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(.....(...........)......)........(........)...)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((..........))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))((((...........))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((.....(..(..........(...............................(..)....................).)..).....)))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).).....((.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..))....(.(((((....))).)).)....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))).. E. coli 50S ribosome bound to compound 47; 23S ribosomal RNA 6pc6 J 118 2.5 RF00001 URS0000366A67_562 32968273 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (((((((((.....((.(((((....(((((((...(.....)...))))..)))...)))))..)).((.......((((((((...)))))))).......))...))))))))). E. coli 50S ribosome bound to compound 47; 5S ribosomal RNA 6pc7 I 2897 2.5 RF02540,RF02541 URS00004B0F34_562 32968273 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccuu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<.<.........>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<....<<<.......>>>....>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<......>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>.>........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>..>.....>>>>>>>>..>>>>><<<<<.........>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<.......>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<.<....<............<<<<<.................................................>>>>>...>....>.>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>.. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((.(......).))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(............)...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((..(....((.........))....)..........(........)...)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((.(......).))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))((((...........))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((.(.....(.............(...............................(..)....................)....).....).)))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(.(((((....))).)).)....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))).. E. coli 50S ribosome bound to compound 46; 23S ribosomal RNA 6pc7 J 118 2.5 RF00001 URS0000366A67_562 32968273 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (((((((((.....((.(((((....(((((((...(.....)...))))..)))...)))))..)).((.......((((((((...)))))))).......))...))))))))). E. coli 50S ribosome bound to compound 46; 5S ribosomal RNA 6pc8 I 2897 2.9 RF02540,RF02541 URS00004B0F34_562 32968273 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccuu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<.<.........>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<.....<<<.......>>>.....>.........<<......>>...>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<......>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>.>........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<..<<....>>...>>>>>........>>>>>>>>..>>>>><<<<<.........>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<.......>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<..<<<.<<<<<.<<<<<<<<.<....<.............<<<<.................................................>>>>....>....>.>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>...>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<.)))..>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>.. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))((((((......)))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((.(......).))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(............)...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.......(...........)...............(........)...)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((..........))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))((((...........))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((.(...((............(.......................................................)...))...).)))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(.(((((....))).)).)....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))).. E. coli 50S ribosome bound to compound 40q; 23S ribosomal RNA 6pc8 J 118 2.9 RF00001 URS0000366A67_562 32968273 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))). E. coli 50S ribosome bound to compound 40q; 5S ribosomal RNA 6pch I 2897 2.9 RF02540,RF02541 URS00004B0F34_562 32968273 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccuu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<.<...<<<.<<<<...<.<.........>>...>>>>.>>>..>..>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<.....<<<.......>>>.....>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<.<<<<......>>>>.>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>.>........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<..<<....>>...>>>>>........>>>>>>>>..>>>>><<<<<.........>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<.......>>>>>..<<<<<<<<.(((.[[......<<<<.[.<<<<..<<<<..<<<.<<<<<.<<<<<<<<.<<.................<.<<.................................................>>.>........>>.>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>...>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>...]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>.. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))((((((......)))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((..........))))...)[)))...(((.(((((........))))))))..).))))))))).(.((.......))...)..))))))......).))..((((((....(((((....))))).((((((((..((((.(((((.....(((...(((.((((...(............)...)))).)))..)).).....)))))..)))..)))))))).)...(((((((((........)))))))))....(((......)))...(.((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.((((.(.(....((.........))....)..........(........)...)))))...)))..))))).))...........]]].)...))))))))))...))))).)((((((.(......).))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(.............((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....((.((((((((.((.....))))))))))...))...[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((.......(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..((.((((..(((.........((((..((....))...)))).........)))))))...)))))((((...........))))........((.(......).(((((.......)))))..)..)....))))...)).))))))).)...)).)))))))).)))).......)).{..(((((....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((.....((............(...............................(..)....................)...)).....)))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(.(((((....))).)).)....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((.....((((....))))....))...))))).))).....))..).))))))))).. E. coli 50S ribosome bound to compound 21; 23S ribosomal RNA 6pch J 118 2.9 RF00001 URS0000366A67_562 32968273 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.....<.<<<<<<<<...>>>>>>>>...>...>>...>>>>>>>>>. (((((((((.....((.(((((....(((((((...(.....)...))))..)))...)))))..)).((.......((((((.(...).)))))).......))...))))))))). E. coli 50S ribosome bound to compound 21; 5S ribosomal RNA 6pcq I 2897 2.6 RF02540,RF02541 URS00004B0F34_562 32968273 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccuu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>....<<<<<.....<<....>>......>>>>>...........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<.<.........>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<.....<<.........>>.....>........<<........>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<......>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<..<<....>>...>>>>>..>....>>>>>>>>>..>>>>><<<<<.........>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<.......>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<.<....<............<<<<<.................................................>>>>>..>.....>.>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>.. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(..]]]..]...).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((.(......).))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.(.((...(............)...)).).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.((((.(......(...........)...............(........)...)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((..........))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))((((...........))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((.....(..(..........(...............................(..)....................).)..).....)))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(.(((((....))).)).)....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))).. E. coli 50S ribosome bound to VM2; 23S ribosomal RNA 6pcq J 118 2.6 RF00001 URS0000366A67_562 32968273 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (((((((((.....((.(((((....(((((((...(.....)...))))..)))...)))))..)).((.......((((((((...)))))))).......))...))))))))). E. coli 50S ribosome bound to VM2; 5S ribosomal RNA 6pcr I 2897 2.5 RF02540,RF02541 URS00004B0F34_562 32968273 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccuu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<.<.........>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<....<<<.......>>>....>>.........<........>...>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<......>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>.>........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>..>.....>>>>>>>>..>>>>><<<<<.........>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<.......>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<..<<<.<<<<<.<<<<<<<<.<<................<<<<<.................................................>>>>>.......>>.>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>...>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>.. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((.(......).))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(............)...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.((((.((.....((....[....))......)........(..].....)...)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((..........))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))((((...........))))........((.(......).(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((.....(..(..........(.......(.......................(..)..).................).)..).....)))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(.(((((....))).)).)....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))).. E. coli 50S ribosome bound to compound 40o; 23S ribosomal RNA 6pcr J 118 2.5 RF00001 URS0000366A67_562 32968273 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))). E. coli 50S ribosome bound to compound 40o; 5S ribosomal RNA 6pcs I 2897 2.8 RF02540,RF02541 URS00004B0F34_562 32968273 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccuu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<........>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<.....<.........>....>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<...<........<<<<<.<.....<<<.......>>>.....>........<<<......>>>..>>>>>....>...>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<......>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>.>........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>..>.....>>>>>>>>..>>>>><<<<<.........>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<.......>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<..<<<.<<<<<.<<<<<<<<.<....<.............<.<<.................................................>>.>....>....>.>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>...>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>.. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))((((((......)))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((.(......).))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(.(.........))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(.....(...........)......)........(........)...)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((..........))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))((((...........))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((.....(..(..........(...............................(..)....................).)..).....)))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(.(((((....))).)).)....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....(.((.....}.......)).)....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))).. E. coli 50S ribosome bound to compound 40e; 23S ribosomal RNA 6pcs J 118 2.8 RF00001 URS0000366A67_562 32968273 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (((((((((.....((.(((((....(((((((...(.....)...))))..)))...)))))..)).((.......((((((((...)))))))).......))...))))))))). E. coli 50S ribosome bound to compound 40e; 5S ribosomal RNA 6pct I 2897 2.8 RF02540,RF02541 URS00004B0F34_562 32968273 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccuu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<....<<.........>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<.........>>>...>>.........<........>...>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<......>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>..>.....>>>>>>>>..>>>>><<<<<.........>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<.......>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<.<<.................<<<<..............<............>.....................>>>>........>>.>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>.. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((.(......).))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(.(.........))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.((((.(.(....(...........)....)........(...........)..)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((..........))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((.(......).(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((................................................(.)(..)...............................)))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(.(((((....))).)).)....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))).. E. coli 50S ribosome bound to compound 41q; 23S ribosomal RNA 6pct J 118 2.8 RF00001 URS0000366A67_562 32968273 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (((((((((.....((.(((((....(((((((...(.....)...))))..)))...)))))..)).((.......((((((((...)))))))).......))...))))))))). E. coli 50S ribosome bound to compound 41q; 5S ribosomal RNA 6pj6 I 2898 2.2 RF02540,RF02541 URS00004B0F34_562 31989172 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccuu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<.......<<<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>.>>>>>>>....>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<........>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<.>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<..<...<<<<.......>>>>...>.........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<..<<....>>..>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<.<<<<<<<.<<.....>>>>>>>>>...>>>>...>>>>...>><..<<<<......>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<<.<<....>>..>>>>>>.>......>>>>>>>>..>>>>><<<<<.........>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<....<............<<<<....<<......<<<<..<<....>>..>>>>...>>..............>>>>...>....>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>.. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((........(((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))))))))).....))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((........)))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((..(...)...))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{....((.((...(((.........)))...)).....(....(......)..).))......)))..))))).))...........]]].)...))))))))))...)))))))(((((..(......)..)))))....))))))(((((((...(((......((((((((....))))))))...)))..))))).)).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))..(.............)..........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((.(......(.(............(.............(....((....))....)....................)...).)......).)))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))).. High resolution cryo-EM structure of E.coli 50S; 23S rRNA 6pj6 J 118 2.2 RF00001 URS0000366A67_562 31989172 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))). High resolution cryo-EM structure of E.coli 50S; 5S rRNA 6pmo B 70 2.65703 RF00005 URS00005115FB_1462 31740854 0030533 0006412 1462 gcggaaguaguucagugguagaacaccaccaaggugggggucgcggguucgaaucccgucuuccgcucca <<<<<<<..<<<<.......>>>>.<<<<<..>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((....[..)))).(((((..))))).....(((((..]....)))))))))))).... Co-crystal structure of the Geobacillus kaustophilus glyQ T-box riboswitch discriminator domain in complex with tRNA-Gly; tRNA-Gly 6pmo A 60 2.65703 URS000197CF52_1462 31740854 1462 aagugggugcgcguuggcgcaucacucggguggaaccgcgggagcugcucucgucccgag ......<<<<<<....>>>>>>..<<<<<<.......<<<<<<<<.>>>>>>>>>>>>>> .....(.(((((....))))).).((((((.......((((((((.)))))))))))))) Co-crystal structure of the Geobacillus kaustophilus glyQ T-box riboswitch discriminator domain in complex with tRNA-Gly; T-box riboswitch discriminator 6pom A 155 4.9 RF00230 URS000197CF54_1423 31740854 0000049 1423 guugcagugagagaaagaaguacuugcguuaccucaugaaagcgaccuuagggcgguguaagcuaaggaugagacgcaacgaaaggcauucuugagcaauaaaaaagaggcugggaucucagcaacuaggguggaaccgcgggaucucgucccua <<<<<.....<<<<<........<<<<<<...<<<<<........<<<<<<...........>>>>>>>>>>>>>>>>>.........>>>>>..>>>>>.........<<<<<<..>>>>>>....<<<<.......<<<<<..>>>>>>>>>. .((((.....(((((........(((((....(((((.....[..((((((..........]))))))))))).))))).........)))))..))))..........((((((()))))))....(.((.......(((((()))))))).). Cryo-EM structure of the full-length Bacillus subtilis glyQS T-box riboswitch in complex with tRNA-Gly; T-box GlyQS leader (155-MER) 6pom B 75 4.9 RF00005 URS00005115FB_1423 31740854 0030533 0006412 1423 gcggaaguaguucagugguagaacaccaccuugccaaggugggggucgcggguucgaaucccgucuuccgcucca <<<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.......)))).(((((.......))))).....(((((.......)))))))))))).... Cryo-EM structure of the full-length Bacillus subtilis glyQS T-box riboswitch in complex with tRNA-Gly; tRNAGly (75-MER) 6ppf A 2471 3.4 RF02540,RF02541,RF00002 URS000197CF51_1423 31665744 0003735 0005840 1423 uuaaguuagaaagggcgcacgguggaugccuuggcacuaggagccgaugaaggacgggacgaacaccgauaugcuucggggagcuguaagcaagcuuugauccggagauuuccgaauggggaaacccaccacucguaauggagugguauccauaucugaauucauaggauaugagaaggcagacccggggaacugaaacaucuaaguacccggaggaagagaaagcaaaugcgauucccugaguagcggcgagcgaaacgggaucagcccaaaccaagaggcuugccucuugggguuguaggacacucuguacggaguuacaaaggaacgagguagaugaagaggucuggaaaggcccgccauaggagguaacagcccuguagucaaaacuucguucucuccugaguggauccugaguacggcggaacacgugaaauuccgucggaauccgggaggaccaucucccaaggcuaaauacucccuagugaccgauagugaaccaguaccgugagggaaaggugaaaagcaccccggaaggggagugaaagagauccugaaaccgugugccuacaaguagucagagcccguuaacgggugauggcgugccuuuuguagaaugaaccggcgaguuacgaucucgugcaagguuaagcagaagaugcggagccgcagcgaaagcgagucugaauagggcgcaugaguacguggucguagacccgaaaccaggugaucuacccauguccagggugaaguucagguaacacugaauggaggcccgaacccacgcacguugaaaagugcggggaugagguguggguaggggugaaaugccaaucgaaccuggagauagcugguucucuccgaaauagcuuuagggcuagccucaagguaagagucuuggagguagagcacugauuggacuagaauucagucaaacuccgaaugccaaugacuuauccuugggagucagacugcgagugauaagauccguagucgaaagggaaacagcccagaccgccagcuaaggucccaaaguauacguuaaguggaaaaggauguggaguugcuuagacaaccaggauguuggcauuuaaagagugcguaauagcucacuggucgagugacucugcgccgaguaccggggcuaaacguaucaccgaagcugcggacuguucgaacagugguaggagagcguucuaagggcugugaagccagaccggaaggacugguggagcgcuuagaagugagaaugccgguaugaguagcgaaagaggggugagaauccccuccaccgaaugccuaagguuuccugaggaaggcucguccgcucaggguuagucgggaccuaagccgaggccgaaaggcguaggcgauggacaacagguugauauuccuguaccaccuccucaccauuugagcaauggggggacgcaggaggauaggguaagcgcgguauuggauauccgcguccaagcaguuaggcugggaaauaggcaaauccguuucccauaaggcugagcugugauggcgagcgaaauuaguagcgaaguuccugauuccacacugccaagaaaagccucuagcgaggugagaggugcccguaccgcaaaccgacacagguaggcgaggagagaauccuaaggugaucgagagaacucucguuaaggaacucggcaaaaugaccccguaacuucgggagaaggggugcucuguuagggugcaagcccgagagagccgcagugaauaggcccaggcgacuguuaaacacaggucucugcgaagccguaaggcgaaguauaggggcugacgccuggcgcaacgaucugggcacugucucaacgagagacucggugaaauuauaguaccugugaaugcagguuacccgcgacaggacggaaccccguggagcuuuacugcagccugauauugaaugccuucuaacccgccgcccuuaucgggcggggagacagugucaggugggcaguuugacgggcggucgccuccuaaaagguaacggaggcgcccaaagguucccucagaaugguuggaaaucauucgcagaguguaaaggcacaagggagcuugacugcgagaccuacaagucgagcagggacgaaagucgggcuuagugauccggugguuccgcauggaagggccaucgcucaacggauaaaagcuaccccgggcuauccgucgcgggcgcaggaaauuugagaggagcuguccuuaguacgagaggaccgggauggacgcaccgcugguguaccaguuguucugccaagggcaucgcuggguagcuaugugcggacgggauaagugcugaaagcaucuaagcaugaagccccccucaagaugagauuucccauuccgcaaggaaguaagaucccugaaagaugaucagguugauaggucugagguggaaguguggcgacacauggagcugacagauacuaaucgaucgaggacuuaac <<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<<......<<<<<<..[..((.>>>.....<<<<<<<..<<<))..]..>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<<<<<<<<.........>>>>>>>.>>.>>....<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<......<<.....>>.....>>>>...<<<....<<<<<<<<....>>>>>>>>......<<<<<<<<<.....<<<<.......<<<<<<<<<<.<<<.....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>.>>>>>..>>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<..<<<<......>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<.<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>......>>>>>.>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<...<<<<<..........<....<<.<..............>.>>...>............>>>>>..>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<.<.<<<<<<..........<<<<<.<<<....>>>.........<........>...>>>>>......>>>>>>.>>>.......))).....>>>>>>.>>>...>>>>>>><<<<<<..>>>>>>....>>>>>><.<<<<<<<.<<......<<<<<.<<....>>.>>>>>...>>.>>>>>>>..>.....>>>>>><......<<....<<<<<<.......>>>>>><<<<....<<<<<.<<<..<<<<<<...<<.....>>.>>>>>>....((<<<<.<<.<.<<<...<<<....>>>...>>>..>>>....<<<<........>>>>.))<<<<<.<<<<<<......<<...<<<<....<<<<..<<<..<<<.<.<<<.<.....[....>.>>>.<...<....<.<<.<.<<<<<<<.<<.....>>>>>>>>>....>.>>..>...>....><..<<..........>>...>>.>>>...>>>...>>>>.........>>>>..>>..>>>>>>>>>>>>>>>.>>>.....<<......>>>>>>>.<<<.......>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<....<<<<....>>>>...>>>>>............<<<<<<<<<..<<<...>>>..<<<<<<<.....<<<....>>>.......>>>>>>>..<<<...>>>...>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<......>>>>>..<<<<<<<<.<<<......<.<<.<<<<<<..<<<<<.<<<<<<<<..<<<....>>>....<<.<<<<<.......>>>>>>>......>>>>>>>>..>>>>>..<<.......>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]......<<<<<<.<<<..))))..>>>>>>>>>.............>>>>..>>>>>....>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<..]...>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<....>>>>....<<<<<<<<.........>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>. ((((((......((((((((((.....(((..(((((((((.(((......((((((.....[[[)))...].((((((...(((]].....)))......))))))...)))....(((....)))(((((((......))))))).(((((((((.........))))))).)).))....((((((.....(...[..)......))))).).........((....))...((((......((.]...)).....))))...((((...((((((((....))))))))....[.(.(((((((.....((((.......((((((((((.(((.....((((......)))).[[(...).(((.....]])))...)))...)))))))))))))).)))))..)).))....((((((((.........))))))))....].(((((..[[[[)))))..)))......)..))))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((...((((..[...))))...))).<.(.(........).).((((((....(((((((.(((((..(((...(((.....)))...)))...((....))..((((.....))))......))))).)))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)<)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((...(((((.(.(.......(...((..................))..).........).).)))))..))))))).))..(((.....((......)).....)))....(((......)))...((((.(((...((([[....(.((((((.....(.....((.(..(((((.((.....{...(((..((....))..........((......))...))).....)).)))))..)))........]].)...))))))))))...)))))))((((((()))))))....))))))(((((((...((......(((((.((....))])))))...))...))))).)).....))))))(......((....((((((.......))))))((((....(((...(...(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((.((((((......((...((((....((((..(((..(((.(.(((.(.....{....).))).((..............(((((((.((.....)))))))))..................))(..((..........))...)).)))...)))...))))(..).....))))..))..))))))))))))))).).).....((......))..)))..(((.....)))...))))..((((....((((((((.((..(....(.......(((((....(.[..).....)))))(((((....((((....))))...)))))(...).......(((((((((.>...........(((((((.....(((....))).......))))))).](((...)))...)).))))))).)..))).)))))))).)))))).....)).[..(((((...>].)))))..((((((.(.(((.......(...((.(((..(((((.(((((((((.(((....)))....((.((((.(......))))))).....)))))))))..)))))..(((....[)))(((((...........].))))).[((...(((((((......((.........))........(.][.[[[.)....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((...((..]]]]..))..)))))......}......)))...))..)....)))).))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}..))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((....))))....(((((((((.......)))))....((((((((.(......(((((....))))).....)..))))).)))...))))...))))))). Bacterial 45SRbgA ribosomal particle class B; 23S rRNA 6ppf B 112 3.4 RF00001 URS00001CC3E3_1423 31665744 0003735 0005840 1423 ugguggcgauagcgaagaggucacacccguucccauaccgaacacggaaguuaagcucuucagcgccgaugguagucggggguuucccccugugagaguaggacgccgccaa <<<<<<<....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<..........<<<<<...>>>>>..........>>..>>>>>>>. (((((((....((((((((......(((((...(.....)...))))..).....)))))).)).((...........((((...))))...........))..))))))). Bacterial 45SRbgA ribosomal particle class B; 5S rRNA 6ppk A 2658 4.4 RF02540,RF02541,RF00002 URS000197CF51_1423 31665744 0003735 0005840 1423 uuaaguuagaaagggcgcacgguggaugccuuggcacuaggagccgaugaaggacgggacgaacaccgauaugcuucggggagcuguaagcaagcuuugauccggagauuuccgaauggggaaacccaccacucguaauggagugguauccauaucugaauucauaggauaugagaaggcagacccggggaacugaaacaucuaaguacccggaggaagagaaagcaaaugcgauucccugaguagcggcgagcgaaacgggaucagcccaaaccaagaggcuugccucuugggguuguaggacacucuguacggaguuacaaaggaacgagguagaugaagaggucuggaaaggcccgccauaggagguaacagcccuguagucaaaacuucguucucuccugaguggauccugaguacggcggaacacgugaaauuccgucggaauccgggaggaccaucucccaaggcuaaauacucccuagugaccgauagugaaccaguaccgugagggaaaggugaaaagcaccccggaaggggagugaaagagauccugaaaccgugugccuacaaguagucagagcccguuaacgggugauggcgugccuuuuguagaaugaaccggcgaguuacgaucucgugcaagguuaagcagaagaugcggagccgcagcgaaagcgagucugaauagggcgcaugaguacguggucguagacccgaaaccaggugaucuacccauguccagggugaaguucagguaacacugaauggaggcccgaacccacgcacguugaaaagugcggggaugagguguggguaggggugaaaugccaaucgaaccuggagauagcugguucucuccgaaauagcuuuagggcuagccucaagguaagagucuuggagguagagcacugauuggacuaggggcgaauucagucaaacuccgaaugccaaugacuuauccuugggagucagacugcgagugauaagauccguagucgaaagggaaacagcccagaccgccagcuaaggucccaaaguauacguuaaguggaaaaggauguggaguugcuuagacaaccaggauguugaguuuaaagaggcucacuggucgagugacucugcgccgaaaauguaccggggcuaaacguaucaccgaagcugcggacuguucgaacagugguaggagagcguucuaagggcugugaagccagaccggaaggacugguggagcgcuuagaagugagaaugccgguaugaguagcgaaagaggggugagaauccccuccaccgaaugccuaagguuuccugaggaaggcucguccgcucaggguuagucgggaccuaagccgaggccgaaaggcguaggcgauggacaacagguugauauuccuguaccaccuccucaccauuugagcaauggggggacgcaggaggauaggguaagcgcgguauuggauauccgcguccaagcaguuaggcugggaaauaggcaaauccguuucccauaaggcugagcugugauggcgagcgaaauauaguagcgaaguuccugauuccacacugccaagaaaagccucuagcgaggugagaggugcccguaccgcaaaccgacacagguaggcgaggagagaauccuaaggugaucgagagaacucucguuaaggaacucggcaaaaugaccccguaacuucgggagaaggggugcucuguuagggugcaagcccgagagagccgcagugaauaggcccaggcgacuguuuagcaaaaacacaggucucugcgaagccguaaggcgaaguauaggggcugacgccaggcgcaacgaucugggcacugucucaacgagagacucggugaaauuauaguaccugugaagaugcagguuacccgcgacaggacggaaccccguggagcuuuacugcagccugauauugaauguugguacagcuuggauagguaggagccuuggaaaccggaggcuucgguggaggcaucgggauacuacccuguauugaccuucuaacccgccgcccuuaucgggcggggagacagugucaggugggcaguuugacgggcggucgccuccuaaaagguaacggaggcgcccaaagguucccucagaaugguuggaaaucauucgcagaguguaaaggcacaagggagcuugacugcgagaccuacaagucgagcagggacgaaagucgggcuuagugauccggugguuccgcauggaagggccaucgcucaacggauaaaagcuaccccgggcggcucaucgcauccuggggcuguagucggucccaaggguugggcuguucgcccauuaaagcgguacgcgagcuggcagaacgucgugagacaguucggucccuauccgucgcgggcgcaggaaauuugagaggagcuguccuuaguacgagaggaccgggauggacgcaccgcugguguaccaguuguucugccaagggcaucgcuggguagcuaugugcggacgggauaagugcugaaagcaucuaagcaugaagccccccucaagaugagauuucccauuccgcaaggaaguaagaucccugaaagaugaucagguugauaggucugagguggaaguguggcgacacauggagcugacagauacuaaucgaucgaggacuuaac <<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.....((.>>>.....<<<<<<<..<<<)).....>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<<<<<<<<.........>>>>>>>.>>.>>....<<<<<<.....<......>......>>>>>.>...[.....<<....>>...<<<<......<<.....>>.....>>>>...(((....<<<<<<........>>>>>>......<<<<<<<<<.....<<<<.......<<<<<<<<<<.<<<.....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>.>>>>>..>>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))....].]].>>>>>>>.]]...............<<....>>....]].........<<<<....>>>>..................>>>>>>>>>>>.......<<<<..<<<<......>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<.<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>......>>>>>.>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<...<<<<<<<<<.....<<<...<<<<<<<.............>>>>>>>..>>.>.....>>>>.>>>>>..>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<.<...........<.........................>.......>.>>>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<..>>>>>>....>>>>>>..<<<<<<<.<<......<<<<<.<<....>>.>>>>>...>>.>>>>>>>........>>>>>><......<<....<<<<<<.......>>>>>><<<<....<<<<<.<<<..<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<..........>>>>))<<<<<.<<<<<<......<<...<<<<....<<<<..<<<..<<<.<.<<<.......{......>>>.<...<....<.<<.<.<<<<<<<.<<.....>>>>>>>>>....>.>>..>...>....><..<<...........>>...>>.>>>...>>>...>>>>.........>>>.>.>>..>>>>>>>>>>>>>>>.>>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<<........<.....<<<<<...............>>>>><<<<<....<<<<....>>>>...>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>..<<<...>>>...>>.>>>>>>>..>.>>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[...<<<<.[[<<<<..<<<<<.<<<<<<<<<.<<<...<.<<<<<<...........<<...<.........<.<<....>>.>.....>..........>>...>>>>>>.>...>>>....<<.<<<<<<.....>>>>>>>>.....>>>>>>>>>..>>>>>..<<.......>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.<<<.<.<<<<..<<<<<<<.<......>.>>>>>..>>.<<<<<.....>>>>>.....>>>>...>...>>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<..}...>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<......>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>. .(((((......((((((((((.....(((..(((((((((((((......((((((..[..[[.))).....((((((...(((]]..]..)))......))))))...)))....(........)(((((((......))))))).(((((((((.........))))))).)).)).....(((((.....(...[..)......)))))...........((....))...((((......((.]...)).....))))...((((...(((((.(......).)))))....[.(((((((((.....((((.......(((((((.((.(((...(.((((......)))))[[(...).(((.....]])))...)))...)).))))))))))).)))))..)))))....((((((((..{......))))))))....].(((((}.[[[[)))))..)))......)).))))))).))...............((....))....)).........((((....)))).............).....)))))))))).....(.(((...((((..[...))))...))).<.(.(........).).((((((....(((((((.(((((..(((...(((.....)))...)))...((....))..((((.....))))......))))).)))))))..((.(...((((((.....((((((((((.(((....(((((........)))))....<)))...(((..((((........)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((.....((((....)))).(((((((((...(((((.(((......((...((..(.................)..))..)).......)))..)))))..))))))).))..(((((((.((......)).)))))))....(((......)))...((((.(((...(((.[[...(.((((((.....(.....((..(((((((.((.....{.(.(((.......................))).)...)).))))))).))...........]]..)...))))))))))...)))))))((((((..))))))....))))))(((.(((...((......(((((.((....))])))))...))...))).).)).....)))))).......((....((((((.......))))))((((....(((...((..(((((((...((.....)).))))))....[[(((.......(((...(((....)))...)))........(((((........)))))]](((((.((((((.......(...((((....((((..(((..(((...(((.......{......)))..(.......(......((((((..((.....)).))))))..........).......).(..((...........))...)..)))...)))...)))).........))))..)...))))))))))).))).)))......(......)...))).((((.....))))..))))..((((....((((((((.((.......(.......(((((....(.[..).....)))))(((((....((((....))))...)))))(...).......(((((((((.>.((.........))...(((((((.....(((....))).......))))))).].((...))....)).))))))).)...)).)))))))).))))))......).[..(((((.....>].)))))..((((((((.(((.((...((((.((((((..(((((.(((((((((.(((.((((..(..(.........(................................................))..)..)))).)))....((.((((((.....)))))))).....)))))))))..)))))..(((.....)))((((((...........))))))(.((...(((((((...(((.(.........).))).....(....[[[.)....)))))))...((((..(((...{..)))..)))).(((....))).))]]].......(((((((.((..]]]]..))))))))).....)}......))))..)))))).(((.((((((..((.((.((........)).))...)).((((.......)))).....)))))..)...)))....(((((((....))).))))....))..)))))))))))[...(((((((...((((..((((((......(....).....)))))).(((((...((((...(((((((((((.}..))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((....))))....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))...)))))).. RbgA+45SRbgA complex; 23S rRNA 6ppk B 112 4.4 RF00001 URS00001CC3E3_1423 31665744 0003735 0005840 1423 ugguggcgauagcgaagaggucacacccguucccauaccgaacacggaaguuaagcucuucagcgccgaugguagucggggguuucccccugugagaguaggacgccgccaa <<<<<<<....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<.......<<.<<<<<...>>>>>.>>.......>>..>>>>>>>. (((((((....(((((.((.....((((((...(.....)...))))..))....)).))).)).((........(.((((.....)))).)........))..))))))). RbgA+45SRbgA complex; 5S rRNA 6q8u A 21 1.99 URS0000EEACF7_2238 31234702 2238 cggcgaagnaccggggagccg ..................... ..................... Structure of the standard kink turn HmKt-7 variant A2bm6A bound with AfL7Ae protein; RNA (5'-R(*CP*GP*GP*CP*GP*AP*AP*GP*(6MZ)P*AP*CP*CP*GP*GP*GP*GP*AP*GP*CP*CP*G)-3') 6q8u B 21 1.99 URS0000EEACF7_2238 31234702 2238 cggcgaagnaccggggagccg ..................... ..................... Structure of the standard kink turn HmKt-7 variant A2bm6A bound with AfL7Ae protein; RNA (5'-R(*CP*GP*GP*CP*GP*AP*AP*GP*(6MZ)P*AP*CP*CP*GP*GP*GP*GP*AP*GP*CP*CP*G)-3') 6q8y 2 1767 3.1 RF01960,RF01959,RF00177 URS0000E60B78_4932 30911188 0003735 0005840 4932 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucagcgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucau ...<<<<<.{.[[[[>>>>><<<<.<<<<<<...<.<...<..........<<...<<....<<....<<..........>>...>>.>>......<<........<<<..<<..<<....<<<..................<<....<<.<<<.....>>>.>>.....>>.........<<<<<..<......>..>>>>><...<<<<<<......(((((((...<....>................>>>>>>.....>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<<..>>>.>....>>............<<<....<<<.....>>>..>>>..>....>.>.....<<<<<<<<<.<<<....>>>.>>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>>.........<<<[[.....<.<<...<<<.<<....<<<<<<.<<<<..............>>>>.>>>>>>....<<<<<<...............................>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........<<...<<<<<<<<.....))))))).>>>>>>>>..>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..]]>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..]]]].}<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<......<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<<<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>...>.>>>>>>>.......>>>>>...>>.>>>>.>>>.....<<<<<<.......<<.....<<..<<<<....>>>>..>>....>>........>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<..........>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>....... ...((((..[.[[[..))))((((.((((((...(.(...((.....(....((..((....((....((..........))...)){))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[[[[[[.(.(....).).....(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...))...).).....(.(((...((((.}...))).))))).)....).).....(((((((((.(((....))).)))))).)))....(.(((.(...........)).))......)..((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((................))).))))))....(((((.................................)))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(....(.((.((......]]]]]]]..)).)).)...).....))...((((.((.((...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)).))..)))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].].((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...((((((.......((.....((..((((....))))..))....))........))))))...........((((((..........)))))).......)..))))).....((((((((.......))))))))......))...)))))))))).)...(.(..((.(..((((.((..(.((((((((.(((..(.((..(...((((((............))))))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>...... Cryo-EM structure of the mRNA translating and degrading yeast 80S ribosome-Xrn1 nuclease complex; 18S ribosomal RNA 6q8y l 17 3.1 30911188 4932 aauccuggauggaacga ................. ................. Cryo-EM structure of the mRNA translating and degrading yeast 80S ribosome-Xrn1 nuclease complex; mRNA 6q8y n 76 3.1 RF00005 URS0000E60BDA_4932 30911188 0030533 0006412 4932 uuccucguggcccaauggucacggcgucuggcuacgaaccagaagauuccagguucaaguccuggcggggaagcca <<<<<<<..<<<..........>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..(((.....[....))).(((((.......))))).....(((((..]....)))))))))))).... Cryo-EM structure of the mRNA translating and degrading yeast 80S ribosome-Xrn1 nuclease complex; P-site tRNA 6q8y m 75 3.1 RF00005 URS0000E60BA3_4932 30911188 0030533 0006412 4932 uccgauauagcguaacggcuaucacaucacgcuuucaccguggagaccgggguucgacuccccguaucggagcca <<<<<<<..<.<..........>.>.<<<<<.......>>>>>....<<<<<.......>>>>>>>>>>>>.... (((((((..(.(.....[....).).(((((.......)))))....(((((..]....)))))))))))).... Cryo-EM structure of the mRNA translating and degrading yeast 80S ribosome-Xrn1 nuclease complex; E-site tRNA 6q8y BQ 3161 3.1 RF02540,RF02543 URS000061F377_4932 30911188 0003735 0005840 4932 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauagaggccuuuauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..<<<..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<.<<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<......<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<.<..>.>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<<..<<<<<<.....>>>>>>>>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...................>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<.<<........>>.>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<.<.....<<<....>>>.....{{<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..[[[..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<<....>>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>.>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<....>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<...<<.....<<<<....>>>>.....>>.>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<..<<<<<<<<<<<<<<<<..>>>>>>.>>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>..........}}...<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))......<<<<<<<..<<<<.))))))>>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>........<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>.....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<<...<<<<<<<<<<]]].>>>>>..>>>>>..>>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<.<..<<<<<......>>>>>..>>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((......((((((....)))))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).<((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)<)))...(((..((.((........)))).)))....))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.(((....((((((.....))))))..))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((.((.....(..........)....)).....(...(........).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))((((((((((.((......((((.((((....))))))))...)))))))))).)).....))))))((.....((.....((((((.......))))))((((.....((((..((...((((((...((.....)).))))))....[[(((.((...((....(((....)))........((.(.((.....).)..)))....))....))...(((((........)))))]]((((..((((..(...((((....)))...(.[[((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....)..)..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((....)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.((((((((..((((((((((((((((())))))).))))))))))....((((.....((((..((((........))))..........]]...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))....))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)((((....((((....((((((((((}}..)))))..)))))...))))...)))).((((...((((.....}.......))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Cryo-EM structure of the mRNA translating and degrading yeast 80S ribosome-Xrn1 nuclease complex; 25S ribosomal RNA 6q8y BR 121 3.1 RF00001 URS000055688D_4932 30911188 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Cryo-EM structure of the mRNA translating and degrading yeast 80S ribosome-Xrn1 nuclease complex; 5S ribosomal RNA 6q8y BS 158 3.1 RF00002 URS00001BF64E_4932 30911188 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Cryo-EM structure of the mRNA translating and degrading yeast 80S ribosome-Xrn1 nuclease complex; 5.8S ribosomal RNA 6q95 2 1504 3.7 RF00177,RF01959,RF01960 URS000080E226_300852 30765567 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<<<.<<...........>>.>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<<....>>>>>>.....>>>>>...<<<<<....<<.....>>...>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>....<<.....>>....>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...............>....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<..<.<<<<<<<........>>>>>>>>...>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<<..>>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((.((.(........))).)))).)))))......(((......(((.((((..((...(((((((.(((((....((((((....)))))).....)))))....((((................))))...(((.....))).)))))))..)))))).)))(((....(((...(((((((.......))))))).)))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.((((.((.((((((((((......((((((.....))))))....))))))))..))).)))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((.(.((..(...)..))..)))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((.(((((......(..........)..........(((((((..(...((((......((((.((....)).))))......(.....)........))))).((.(((...((.(((.(....(((((((((....)))...(.(.......))...)))))).....((((.(((((((........................))))))).....(((((....)))))........)))).....).).))....)).)))))....)))))))...)).))).)))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((..........)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.(((.....(((....)))..))).)..)))))))))))))..))..))))..).))...)..)..(((.(((((....))))).)))}.. Structure of tmRNA SmpB bound in A site of T. thermophilus 70S ribosome; 16S RIBOSOMAL RNA 6q95 7 77 3.7 RF00005 URS000041AF00_562 30765567 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucggnucaaauccggcccccgcaacca .<<<<<...<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>.>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(.(((..]....)).))))))))..... Structure of tmRNA SmpB bound in A site of T. thermophilus 70S ribosome; tRNA-fMet 6q95 8 76 3.7 RF00005 URS0000E60B80_562 30765567 0030533 0006412 562 gcccggauagcucagucgguagagcaggggauuuuuaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..))))(((((.........)))).)...((.((..]....)).))))))))).... Structure of tmRNA SmpB bound in A site of T. thermophilus 70S ribosome; tRNA-Phe 6q95 1 2831 3.7 RF02540,RF02541,RF00002 URS000080E0F3_300852 30765567 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucgggggcccucggccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcgccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccuggcgccggugaaauccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu .........<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.....((.>>>.....<<<<<<<..<<<)).....>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<.<<.....>>.>>>>>.....<<<.<<<.....<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>....>>>..>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<....>>>>>>>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<...<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<....<<...<<<<<<<<.....<......>......>>>>>>>>..>>.....>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<.<<.<<<..<<<.........>>>..>>>......................>>.>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<.......>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.....[[[[.....>>>><<<...<<<<<<<<<..<<<<<.<<.....>>>>>>>.......>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<.<<<<<.............<<<<<....................>>>>>....>>>>>.>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...................<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....... .........((((((((((.....(((..((((((((((((......((((((..[..[[.))).....((((((...(((]]..]..)))......))))))...)))....(((....)))(((((((......))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...((((..((.....))..)))).....(((..(......(.....(((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)).)...).....)...))))....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((((..((.....)).)))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))..)))))))))))))..((.(...((((((.....((((((((((.(((.....(((((......))))).....[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...((((((((....(.(....)...)...))))))))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((((.............((..(...(((.........)))...).......................)).........))))))).))..........]]].)....))))))))))...)))))))(((((((.......)))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((...(..{{....).))))(((...(((((((((.(.((...((.....))..))..).....)))))))))..)))(....(((....)))......))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((.........))))))))))(...).......((((.((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).)).)))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.((.((.(((.(((.(...((.(.(..........((((....................)))).)..)))...).))).)))...(((((....)))))....)).)).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))....(........).....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))....... Structure of tmRNA SmpB bound in A site of T. thermophilus 70S ribosome; 23S RIBOSOMAL RNA 6q95 3 119 3.7 RF00001 URS000080DE2B_300852 30765567 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<<....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>> ..(((((.((.....(((((.((....(((((((...(.....)...))))..)))...)).))).))(((.......((.(((((....))))).)).......)))..)).)))).) Structure of tmRNA SmpB bound in A site of T. thermophilus 70S ribosome; 5S RIBOSOMAL RNA 6q95 4 319 3.7 RF00023 URS000046D244_300852 30765567 0006401 300852 gggggugaaacggucucgacgggggucgccgagggcguggcugcgcgccgaggugcggguggccucguaaaaacccgcaucgcggcuuaaugaccgcgaccucgcccgguagcccugccgggggcucaccggaagcggggacacaaacccggcuagcccggggccacgcccucuaaccccgggcgaagcuugaagggggcucgcuccuggccgcccguccgcgggccaagccaggaggacacgcgaaacgcggacuacgcgcguagaggcccgccguagggaccuucggacggggguucgacuccccccaccuccacca <<<<<<<............<<<<<<<<.<<...<<<..<<<..<....<<<<...[.((....>>>>.......))]..<<<<<<........>>>>>><<<<<<<<<<.<<<...((((((.>>>..>>>>..>>>>>>.......))))))...<<<<<<<......(......>>>>>>>..............)......<<<<.....<..((..((..>.......>>>.>............))..)).......>.....>>>.>>>...>>>>>>>>>>...<<<<<.......>>>>>>>>>>>>.... (((((((............((..((((.(....((.(.......(...((((....[.[[...)))......].]]...((((((........))))))((((..((((...(...[[[[[[.)....))))....)))).......]]]]]]..(.(((((......[[.......))))).).............]]....[............(..(((..............]............)))..)...)..).........).))....)))))..))...(((((.......)))))))))))).... Structure of tmRNA SmpB bound in A site of T. thermophilus 70S ribosome; transfer-messenger RNA (tmRNA) 6q97 1 2903 3.9 RF02540,RF02541 URS00021ED9BC_562 30765567 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaacccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<.<<<....(((.>>>.....<<<<<<<..<<.))).....>>......>>>>>>>....>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<...........>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...(((.....<.......<...<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>...>....>...........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<......>....]].........<<.........>>.............}....>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<.....<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<.<.....>.>>.....>>>>>>>>>>>>...<<.<...<<<<<<.....<<<<<<<<...<<<....<<<<<<......>>>>>>.....>>>...<<<.<<.<<........>>.>>>>>.....>>>>>>>>...<<<.....>>>......>>>>>>.......>>>..<<<<......<<<<<....>>>>>.<.<<<<<<...<<<<<.<.<<....<......<<.<<<<...<<..<.........>...>>...>>>>.>>......>.....>>.>>>.>>>...>>>>>>..>...<<<<<..<<<......>>>..>>>>>....<<<......>>>...<<<<.<<<...<<<((......<<.<<<...........<<..<<<<<...<.........<.....<.....................>..........................>.....>...>>>>>.>>............)).....>>>.>>.>>>...>>>>>>><<<.<<<<......>>>>.>>>......>>>>..<<<<<...<<<<.....<<<<<<<<....>>>>>>>>..>>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<.<..<<<...<<<....>>>...>>>...>>>...<<<<........>>>>.))<<<<<<<<<<.<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<..<.<<<<<<<<<<<<..........>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>.>........>>>>...>>.....>>>>>>>>>>.>>>..>>.....<<......>>.>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<...<...............<<<<<....<<..>>.....>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<......>>.......>>>>>>>..<<<<..<<..<<<<<<<..<<<........<...<<.<<....>>..>>...>........>>>>>>>>..>>>>.<<<<<<.......>>>>>>....................<<<<<.......>>>>>..........>>>>...>>.>>>>>>>.....>...>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[.<<<<..<<<<..<<<.<<<<<.<<<<<<.<<<<..<<............<<<<...<<.......<<.<<<<......>>>>.>>....>>.............>>>.>..>.>.>>>>.>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>...>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>...]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<.<<<......>>>.>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<.<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<.<.)))..>.>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>..>>.<<<<<.....>>>>>.....<<..<<<<.........>>>>....<<.<<..<..<<....<<<<<....>>>>>...>>....>.>>..>>.....>>.....>>>>>>>>. ((((.(((..........((..((.....((.(.((.(((((.((........(..((..[..[....))......(.((....(....]..]...)........)).)......)....(((....))).(.((........))..).((((((...............))))))......(..(((.....(...[..)......)))...)......................(((.....((.]...))....))).....(.((.(...............((((..(.(((...(((((......)))))[[......(((.....]])))...)))...)..))))............)...).....(((......[..........))).......(((((].[.[[)))))...))......))..)))))..))................(.....)....)).........(.((......))).............).....))..)).........(.((((...((((......))))...)))).[.(.(........).).(((.......(((((((((((((..(((....(.....)....)))...((....))..(.(........)).....)))))))))))))..(.(....((((((.....((((((((((...(.....(((.(.......)))).....[).....(((.((.((........)).)))))..).))))))))).(.(((.....)))...)..))))))........))..(((.((....(((((....))))).((.(.(((..((..((.(.(.....((.....((.((((...((..(.(.....).)...))...)))).))....).).....)..)))...)..))))..)).)......(((.((........)).))).......(.(.......))....(((.((....((([.[...(.....(......(.....((..(..((...((.....{..((.....(...................).......(..............)...))....).)..))..).))............]].).....)...))))....))))).((((...(......)...)))).....)))))..(...(............((..((((....))))..))........)...)...........)))(......((.....(.((((.......)))).)((((....((((..((..(((((((...((.....)).))))))....[[(((..((...(((...(((....)))...)))...)).....(((........)))..]](((.(((((...(...((((....((((..(((..((((((((((((...{{{.).))))))((..((.....(((((.((((((..(......))))))).)..)))).....))...))(...(.((....))..)...))))))...)))...)))).........))).)..).......))))).))).))).))).....((......)).)))).((.(.....).))..))))..((((....(((((((..((..(....(.......(((((....(.{..).....)))))(.((((.....(((....(((.....)))....)))...)))).)(...).......((((..(((.].((.........)).....(((((......((....))........)))))...}(((....(..(((((((..(((........(.(((..((....))...)).))........))))))))..)))...(.(............).)........(...........(((.((......))))).....).....)))...)).)..)))).)..)))..))))))).)))))).....)).....((((.....]..))))...(.(..(((.(((.(.......((((.(.(.((..(((...((...((((.(.((....(.(..(.(...........(((((..(..........(..............).......)............)))).)..).).)..)...).))....((.(..(((.....)))..))).....))))...))....)))..(........[..)((((((..........]))))))(......(((((((...((.((.........)).))...........[[......)))))))...((((....((....))....)))).(((....)))...]]........((...(..((..]].]..))..)..)).....).......))....)))))).......(....(.((((((...((.......))...))))))...)....)........(...(((.((...((.(.(((........).)))...)).(.(((.....))).)......).))..)...)...).....(.((..(....)...)).).....)..))))))...))[...(....((....(((...((((((.....(....)....))))).).(((.(...(......(((((...(.(}}}.)..)....)))))......).).)).)..(((....((((.....}.......))))....))).)))...]....))....)..((.(.(..)...))).....((..(((((.......)))))........(.....((....((..(....)..))...))......)..........)).....))).)))). Structure of tmRNA SmpB bound in A site of E. coli 70S ribosome; 23S ribosomal RNA 6q97 2 1534 3.9 RF00177,RF01959,RF01960 URS000081169C_562 30765567 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca ........<<<<....((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<.<<<<........>>.>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<..<..<<<<<......>>>>>.....>>>.>.....<<<....>>>....<<<<<<..<......>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<...<<<<<<.........>>>>>>.>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<.<<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>...<.<<<<<......<.<<<<.<<<.......>.>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>.>..........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<......>>>....>>>..))))...<<<<.<<<<<<..<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<..<<<<.....<<<<....>>>>................>>>>...>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<<..<<<.....>>>>>.....>>>>>>......<<<<.....>>>>.........>>>>.........>>...>>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>....>>>>>>>>>.>.....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>.>>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ........(((....[..[...)))....(..((.(..((((((((.....(((.(((..(((..((.(...((.(.(.(........)..)..))).)..)))))......(((......(((((((...(...(((((((.(.(......((((((....)))))).......).).....(.(....)..)....(((((...(....).)))))..)))))))..)..)))))))(((......(..(((((.((.......).)))))))........)))..(.(((.((....)).)...)).)))).((((.((.........))))))..(((....)))....)))))).........(((....((.(....).))..)))..)).))))))..((((......((((....)))).....))))...(.(((((..((...(((((((((.......)))))))).)...)..).)))))....)..((((.[[[...(((((.....((.]]])).......))))).))))..).).))...............([[...(..(((.(..((.(((.(((.((((((((((.......(((((.....)))).)....))))))))..))))).)))..(((((((((....(..(..(....(((((((...(..........)......)))))))....).......((....))...)..)...))).)))))..)))...)))).....(((......((....(.............)....))...)))......{...(.((((...((((((.((((.....)))).))))).).......]].......)))).)))...(((.........(.....)......)))...]...].(((..((((((..((..(((....(((((..(((......((........))..........(((((((..(....(.(.........(((....))).........(...)......)..).).((........(.(((.(....(.((((..(....).....(((......)))...)))).).....((((..((((((...((..(((.....)))))....)))))).......((((.....)))).........)))).....).).))....).....))....)))))))...)).)..))))).(....((.(.(.....(((..((...(.(....).)...))....))).....).).)).......(....(.(..((........))...))....)..)....))).......(..((.........))..)........))....)))).)))).)...(.(..((.(..(((...(....((...((((.....(((((.........(....).......)))))....))))...))....)...)))...).))...)..)...(.(..(((....)))..)..)}..... Structure of tmRNA SmpB bound in A site of E. coli 70S ribosome; 16S ribosomal RNA 6q97 3 120 3.9 RF00001 URS0000049E57_562 30765567 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<......<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.....<..<<<<<<<...>>>>>>>...>....>>....>>>>>>>>>. .(((((..((.....((..((((....(((.(((.............)))...)))...))))...)).((..........(((((...)))))..........))...))..))))).. Structure of tmRNA SmpB bound in A site of E. coli 70S ribosome; 5S ribosomal RNA 6q97 8 77 3.9 RF00005 URS0000093D11_562 30765567 0030533 0006412 562 ggcuacguagcucaguugguuagagcacaucacucauaaugauggggucacagguucgaaucccgucguagccacca <.<<<<...<<<<.........>>>>.<<.<.........>.>>.....<<.<<.......>>.>>.>>>>.>.... (.(.((.....................((.............)).....((.((.......)).)).)).).).... Structure of tmRNA SmpB bound in A site of E. coli 70S ribosome; tRNA-Met 6q97 4 334 3.9 RF00023 URS00006A1445_562 30765567 0006401 562 ggggcugauucuggauucgacgggauuugcgaaacccaaggugcaugccgaggggcgguuggccucguaaaaagccgcgcuuuagcagcuuaauaaccugcuuagagcccucucucccuagccuccgcucuuaggacggggaucaagagaggucaaacccaaaagagaucgcguggaagcccugccugggguugaagcguuaaaacuuaaucaggcuaguuuguuaguggcguguccguccgcagcuggcaagcgaauguaaagacugacuaagcauguaguaccgaggauguaggaauuucggacgcggguucaacucccgccagcuccacca <<<<<<<...............<<<<<<............<<<......[.((..<<<.....))]........>>>..<<<<<.<<<.........>>>..>>>>>..<<<<..<<<<..<<<........>>>..>>>>......>>>>....................<<<...........(((........>>>............))).......<<<.....<<...((.((..>>.....>>>.............)).))............>>>...........>>>>>>.....<<<<<.......>>>>>>>>>>>>.... ((..((...................(.............((.(......[......((.......]........))..(((.((.(((.........)))..)).)))........((...(((........)))...))................................(............[...........)...............].......((..........................))..............................).))............)........(((((.......))))).))..)).... Structure of tmRNA SmpB bound in A site of E. coli 70S ribosome; transfer-messenger RNA (tmRNA) 6q97 7 77 3.9 RF00005 URS000052A6C3_562 30765567 0030533 0006412 562 gcguccguagcucaguugguuagagcaccaccuugacauggugggggucggugguucgaguccacucggacgcacca ..<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>...... (.(((((..((((.........)))).(((((.......)))))......((((.......)))).))))).).... Structure of tmRNA SmpB bound in A site of E. coli 70S ribosome; tRNA-Val 6q98 1 2903 4.3 RF02540,RF02541 URS0000B21DEA_562 30765567 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaacccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[...((.>>>.....<<<<<<<..<<<))...].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<....<<<.<.....>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<.<<<<<<.........>>>>>>.>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<......>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<.<<....<<<....<<.<<<<...<<................>>...>>>>.>>...>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<.<<<......>>>.>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<...<<<<...<........<<<<<.<<...<.<.........>.>...>>........<<<......>>>..>>>>>....>...>>>>..>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<......>>>>>>>>....>>>>>><.<<<<....<<<......<<<<<<<<....>>>>>>>>...>>>...>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<.<..<<<...<<<....>>>...>>>...>>>...<<<<........>>>>.))<<<<<<<<.<.<<...<<<<....<<.<..<<<..<<<<<<<<<<<....(((...>>>>>>.<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>....<<<<<....>>>>>....>>>>>...>>>....>>.>........>>>>...>>.....>.>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<.<..<......>...>.>>>........>>>>>>>>..>>>>><<<<<.........>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<.......<................<<............<<.<<........>>.>>...................>>.......>......>.>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<....<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>....<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<....<<<<<...<<.......>>...>>>>>.....>>>.>.......<<<<<...<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>.......>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<....<<<...<<<<<<<<<<.)))..>>>>>..>>>>>...>>>..>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<.........>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. (.((((((......((((((((((......((..((((((((.((((......(((((..[...[[..)).....((.(((...((.]]...]..)).......))).))...)))....(((....)))((((.((....)).)))).(..((((((.........))))))..).))....(((.(.....(...[..).......))))...........((....))...(((((.....((.]...))....)))))...((((.((((......((.((((((.(((.(((...((..(......)..))[[(...)..((.....]]))....)))...))).)))))).))...))))...).....(((((....[........))).))......(((((].[[[[)))))..)))......))..)))))).))................(.....)....))(.....)...(((.....)).)...................)))))))))).....(.((((...((((......))))...))))...(.(........).).((((((....(((.(((((((.(..((....((.....))....))...((....))..((((.....)))).....).))))))).)))...((.....(((((.....((((.(((((.((((...((((((......))))))...).)))...(((..((((........)))).)))..).)))).)))).(.(((.....)))...)..))))).........))..((((((....((.((....)).)).((((((((..(.((((..((.....(((....((.(((....((................))....))).))...)).).....))..)).))...)))))))).)...(..(((.((.........)))))..)....((........))...((((.(((...((([[[...(.((.(((.....(.....((....(((..(.(.....{..((((..(...(.(.........).)...)......(..(((......)))).))))....).)..)))...))...........]]].)...))).))))))...))))))).((((..(......)..)))).....))))))(.(((.....(((.......((((..(....)..))))....)))....)))..).....))))))(......((.....((((((.......))))))((((....((.(..((..(.(((((....(.....)..))))).....[.(((....(....(...(((....)))...).....).....(.((........)).)..](((((.((.(.((...(((.....((((..(((....((((((((.(...{{..)..))))).(..((.(...(((.(..(((((.((.....)))))).).)...)))..{).))...).(..(.((......)).)...)))).....)))...))))(..)......)))...)).....).)).))))).))).))).....((......))..))).(((.......)))..))))..((((....((((((((.((..(....(.......(((((....(.[..).....)))))((((.(.....(((....(((....})))....)))...).))))(...)........((((((((...((.........))...((((.((.....(((....))).......)).)))).]((((.(((..(.(((((..((.........((.(................))).........)))))))...))))(.(((.........))).)........((..........((((.(......)))))..)..)....))))...)).))))))..)..))).)))))))).)))))).....))....(((((........)))))..(((.((((..((.((......((...((((((..(((...(((.(((((.(((.........(..................(..(..............((....))...........)............).........).........)))...(((.((((((.....)))))))))....))))).)))....)))..(((......[)))((((((..........])))))).[......((((((...(((((.........))))).....((][.[[[))....))))))....((((..((.(..{.).))..)))).(((....)))...]]].].....((.(((..((..]]]]..)).))).))......}......))))..))..))......((((.....(((((...((.......))...)))))......)).).)......(.((.(..(((..(((((.(((......))).))..)))..((((.....))))......)).)...)...))..).....(.(((((....))).)).)....))..)).)))).)))[...(((((((...((((..(((((((.....(....)....))))))).(((.(.....((...((.(((.((.(.}}.).)).)..).)))...))...).)))....((....((((.....}.......))))....))..))))..]....)))))))(.((((.......))))(....((..(.(...........).)......((((((..((....(((((....)))))...))...))))).).......))..).))))))).). Structure of tmRNA SmpB bound in P site of E. coli 70S ribosome; 23S ribosomal RNA 6q98 2 1534 4.3 RF00177,RF01959,RF01960 URS0000E60B97_562 30765567 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<..........>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<...<....>.>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>...>>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<.......<<<....>>>......>>>>..<<.<<<<<.......<<<<<<<<<.......>>>>>>>>.>........>>>>>....>>.<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<....<<<......>>>.......>>>>>>.>..........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>..<<......<<<<....>>>>....>>...)))).]<<<<<.<<<<<<<..<..<<<<....<<<<<<<........<<........>>..........<<<<<<<........<.<<<..<<<<<<<....>>>>>>>.............>>>.>....<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<.<......>.>>..>>>>>>.....<<<...<<<<<<...<...<<<.....>>>.>....>>>>>>......<<<<<.....>>>>>.........>>>.......>.>>>...>>>>>>>>>...>>>>>>>......>>>>>>>.......<<.<<......<<<...<...<<<....>>>...>.....>>>......>>.>>.......<....<<<<<<<........>>>>>>>....>......>>>>.....<<<<<<<.........>>>>>>>......>....>>>>>>>>>>.>>.......<<.<.<<<<..<<..<<<<<<<<<<<<....<<<<<<.<<<...<<<..>>>..>>>>>>>>>...>>>>>>>>>>>>..>>..>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>...... ........[[....((((.....]].((((.((.((..(((((((((....((..(((..(((..((.((...((.(((..........)))..)).))..)))))......(((.......((((.(..((...(((((((.(.((......(((((....))))).......)).).....(((....)))....(((.((..(......))).))).)))))))..)).).)))).(((....(((..(((((((.........))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...))).)).).....(.(((...(((((....)))).))))).)).))))))..(((.......((((....))))......)))...(..(.((...(....((((.(...........).)))).....)....)).).....)...(((([[[...(((((.....((.]]])).......)))))))))...)).))))))..........((([[...(.((((...(((.((((..(.((((((((((......((((((.....))))))....))))))))..)))..))))..((.((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))).))).)..))))...)))).....(((((...((...((((.........))))...))))))).......{...((((((..(((((.(.((((.....)))).).)))))...((..]])).....)))))))))).(((......((.(....).))....)))....)).))((((.(((.(((.((..(((.....((((((.........((........))........(.(((((((........((.((...((..((....))..))..............)).)).....((.(((...(((.((.(....(((((((((....)))...(.(.......))...)))))).....((.(...(((((....(..(((.....)))).....)))))....(..(((((.....))))).....)..).)).....).).).)...)).)))))....))))))))......))))))..(....(.((.......(((...(...((......))...).....))).......))..)......(....((((.((........)).))))....)..)....))).....((((((...........))))))......))...))).)))))).)...(....((...(((...((..(.(.(.(..((.....(((((..((((..((....)).)))).)))))....))...).)).)..))...)))....))......)..(((((((((....)))))))))}..... Structure of tmRNA SmpB bound in P site of E. coli 70S ribosome; 16S ribosomal RNA 6q98 3 120 4.3 RF00001 URS0000049E57_562 30765567 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. .(((((((((.....((.(((.(....(((.(((.............)))...)))...).)))..)).((.......(..(((((...)))))..).......))...))))))))).. Structure of tmRNA SmpB bound in P site of E. coli 70S ribosome; 5S ribosomal RNA 6q98 4 363 4.3 RF00023 URS000037602E_562 30765567 0006401 562 ggggcugauucuggauucgacgggauuugcgaaacccaaggugcaugccgaggggcgguuggccucguaaaaagccgcaaaaaauagucgcaaacgacgaaaacuacgcuuuagcagcuuaauaaccugcuuagagcccucucucccuagccuccgcucuuaggacggggaucaagagaggucaaacccaaaagagaucgcguggaagcccugccugggguugaagcguuaaaacuuaaucaggcuaguuuguuaguggcguguccguccgcagcuggcaagcgaauguaaagacugacuaagcauguaguaccgaggauguaggaauuucggacgcggguucaacucccgccagcuccacca <<<<<<<.............<<<<<<<<.......<<..<<<......<<<<...((((....>>>>......))))..............................<<<<<<<<<<.........>>>>.>>>>>><<<<<<.<<<...<<<..[(((((>>>...>>>.....>>>>>>..........))))).].<<<<...<<<<...((...>>>>...>>>>.............)).....<<<<<....<<...((.....>>....>>>>.>..............)).............>>>..>>......>>>>>>>>...<<<<<.......>>>>>>>>>>>>.... ...((((..............(((((((.......((..((.(......[.....((((......].......)))).......(.)....................((((((.(((.........)))..)))))).(((.(((((........[.[[[[......)))....)).)))...........]]]]..]..((......((...[....))......))...............]......(.....(.(....[[......))......)................]]............).))..))......)))))))....(((((.......)))))))))....... Structure of tmRNA SmpB bound in P site of E. coli 70S ribosome; transfer-messenger RNA (tmRNA) 6q9a 1 2903 3.7 RF02540,RF02541 URS00021ED9BC_562 30765567 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaacccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<....<.<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>..>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<..<<.......>>...>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<.........>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<.<.<<<...<<<....>>>...>>>..>>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<<..>>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<<.<<....>>..>>>>>>.>......>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<.<<................<<.....<<.......<<.<..<......>..>.>>....>>...............>>.......>>.>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((.(((...(((]]]..].))).......))).))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((.(((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))))))).)))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..(((.......))).....)))))))))))))..((.(...((((((.....(((((.((((.(((....((((((......))))))....[)))...(((.(((((........))))))))..).))).))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((..(.........)...))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{...(((.(((..((((.......))))..))).....(..(((......)))).))).....)))..))))).))...........]]].)...))))))))))...)))))))((((...((....))...))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]]((((((((((.((...((((....((((..(((..(((((.((((((...{{{.).))))).((...(((...(((((.((((((.((.....)))))))).)..))))..[)))....))(...((((....))))....))))))...)))...))))(..).....))))...)).....)))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....((.....(((....]))).....))...))))))(...).......((((((.((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..((.........(((((..((....))...))))).........)))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...))..)))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((((..(.(......(..........(.....((........(((...(....)...))).....))...............).)......)..).))))))...(((..(((((.....))))).)))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....(.][.[[[.)....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....((.((((.((..]]]]..)))))).)).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(.(((((....))).)).)....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Structure of tmRNA SmpB bound past E site of E. coli 70S ribosome; 23S ribosomal RNA 6q9a 2 1534 3.7 RF00177,RF01959,RF01960 URS000081169C_562 30765567 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<......>>>>>>.>>>.>..>>>>>......<<..<....<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<......>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>>>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<.......<<<....>>>......>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<......<<<....>>>.................>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ........(((...[.[[[...))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((.((((........))))..)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((.(....).))))......)).).....(((....)))....((((((..(......))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(...(((((((((.......)))))))).)...)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.(((((((((.......((((((.....)))))).....)))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((((.......)))))))))))...((..]])).....)))))))))).(.(......((((....))))....).)...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((.((((..(...(((....)))...)...(......)..))))..))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..((.......))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((...(((((((((((....((((((.((((..((....)).))))))))))...)))))))))))...))).))))..).))...)..)..(((((((((....)))))))))}..... Structure of tmRNA SmpB bound past E site of E. coli 70S ribosome; 16S ribosomal RNA 6q9a 3 120 3.7 RF00001 URS0000049E57_562 30765567 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau .<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>.. .(((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((.(((((...))))).)).......))...))))))))).. Structure of tmRNA SmpB bound past E site of E. coli 70S ribosome; 5S ribosomal RNA 6q9a 7 76 3.7 RF00005 URS00005F0912_562 30765567 0030533 0006412 562 ggggcuauagcucagcugggagagcgccugcuuugcacgcaggaggucugcgguucgaucccgcauagcuccacca <<<........<.........>....<<<<<.......>>>>>.....<<<<<.......>>>>>...>>>..... (.(...............[.......(((((.......))))).....(((((..]....)))))...).)..... Structure of tmRNA SmpB bound past E site of E. coli 70S ribosome; P-site tRNA 6q9a 4 363 3.7 RF00023 URS000037602E_562 30765567 0006401 562 ggggcugauucuggauucgacgggauuugcgaaacccaaggugcaugccgaggggcgguuggccucguaaaaagccgcaaaaaauagucgcaaacgacgaaaacuacgcuuuagcagcuuaauaaccugcuuagagcccucucucccuagccuccgcucuuaggacggggaucaagagaggucaaacccaaaagagaucgcguggaagcccugccugggguugaagcguuaaaacuuaaucaggcuaguuuguuaguggcguguccguccgcagcuggcaagcgaauguaaagacugacuaagcauguaguaccgaggauguaggaauuucggacgcggguucaacucccgccagcuccacca <<.<<<................<.<<.<.<....<.....<<..<<<<<<<<<.(((((...>>>>>......)))))..............................<<<<.<..<.<.....>.>....>>>>>..<<<<.<<<<...<<<...((((.>>>...>>>>.....>>>>............))))....<<<....<<<...(((..>>>....>>>.............)))....<<<<..<<..<<...((.((..>>..>>..>>>>...........)).))....>>>>.....>>....>.....>>.>>.>.....<<<<<.......>>>>>.>>.>>>.... (..(....................((..................(((.(((((.[[[[[...)))))......]]]]]............................................................((((..((.(..((..........))..).))......))))...................(((......((....[[..))......)))............]].....((((..((..(....[..[[...)..))..))))...........]]..].....)))....................)).......((.((.......)).))....).).... Structure of tmRNA SmpB bound past E site of E. coli 70S ribosome; tmRNA 6qcs V 14 3.1 URS000080E200_11520 31160782 11520 aguaguaacaagag .<<....>>..... .((....))..... Influenza B polymerase pre-initiation complex; 5 end 6qcs R 15 3.1 URS0000EEAD16_11520 31160782 11520 accucugcuucugcu ............... ............... Influenza B polymerase pre-initiation complex; 3 end 6qct R 13 3.2 URS0000EEAD16_11520 31160782 11520 cugcuucugcuau ............. ............. Influenza B polymerase elongation complex; 3 end 6qct M 13 3.2 URS0000EEAD28_11520 31160782 11520 naauuagcagaag ............. ............ Influenza B polymerase elongation complex; capped RNA 6qcv M 15 3.24 URS0000EEAD0F_32630 31160782 32630 ngaaugcuauaauag ............... ............... Crystal structure of influenza B polymerase initiation state with capped 14-mer RNA primer and CTP; RNA (5'-D(*(GDM))-R(P*GP*AP*AP*UP*GP*CP*UP*AP*UP*AP*AP*UP*AP*G)-3') 6qcv R 21 3.24 URS0000EEAD16_32630 31160782 32630 uauaccucugcuucugcuauu ..................... ..................... Crystal structure of influenza B polymerase initiation state with capped 14-mer RNA primer and CTP; RNA (5'-R(*UP*AP*UP*AP*CP*CP*UP*CP*UP*GP*CP*UP*UP*CP*UP*GP*CP*UP*AP*UP*U)-3') 6qcv V 14 3.24 URS000080E200_32630 31160782 32630 aguaguaacaagag .<<....>>..... .((....))..... Crystal structure of influenza B polymerase initiation state with capped 14-mer RNA primer and CTP; RNA (5'-R(P*AP*GP*UP*AP*GP*UP*AP*AP*CP*AP*AP*GP*AP*G)-3') 6qcw M 15 2.88 URS0000EEAD0F_32630 31160782 32630 ngaaugcuauaauag ............... ............... Crystal structure of influenza B polymerase initiation state with capped 14-mer RNA primer; RNA (5'-D(*(GDM))-R(P*GP*AP*AP*UP*GP*CP*CP*AP*UP*AP*AP*UP*AP*G)-3') 6qcw R 21 2.88 URS0000EEAD16_32630 31160782 32630 uauaccucugcuucugcuauu ..................... ..................... Crystal structure of influenza B polymerase initiation state with capped 14-mer RNA primer; RNA (5'-R(*UP*AP*UP*AP*CP*CP*UP*CP*UP*GP*CP*UP*UP*CP*UP*GP*CP*UP*AP*UP*U)-3') 6qcw V 14 2.88 URS000080E200_32630 31160782 32630 aguaguaacaagag .<<....>>..... .((....))..... Crystal structure of influenza B polymerase initiation state with capped 14-mer RNA primer; RNA (5'-R(P*AP*GP*UP*AP*GP*UP*AP*AP*CP*AP*AP*GP*AP*G)-3') 6qcx M 16 3.08 URS0000EEAD1E_32630 31160782 32630 ngaaugcuauaauagc ................ ................ Crystal structure of influenza B polymerase initiation state with capped 15-mer RNA primer; RNA (5'-D(*(GDM))-R(P*GP*AP*AP*UP*GP*CP*UP*AP*UP*AP*AP*UP*AP*GP*C)-3') 6qcx R 21 3.08 URS0000EEAD16_32630 31160782 32630 uauaccucugcuucugcuauu ..................... ..................... Crystal structure of influenza B polymerase initiation state with capped 15-mer RNA primer; RNA (5'-R(*UP*AP*UP*AP*CP*CP*UP*CP*UP*GP*CP*UP*UP*CP*UP*GP*CP*UP*AP*UP*U)-3') 6qcx V 14 3.08 URS000080E200_32630 31160782 32630 aguaguaacaagag .<<....>>..... .((....))..... Crystal structure of influenza B polymerase initiation state with capped 15-mer RNA primer; RNA (5'-R(P*AP*GP*UP*AP*GP*UP*AP*AP*CP*AP*AP*GP*AP*G)-3') 6qdv 2 120 3.3 RF00004 URS0000E60B75_9606 30705154 0045131 0000348 0005686 9606 aucgcuucucggccuuuuggcuaagaucaaguguaguaucuguucuuaucaguuuaauauauauuaaaagauuuuuggaacugcaucgaccugguauugcaguaccuccaggaacggugc .....................................................<<<<<<..>>>>>>...............<<<<<<.<<<<<.............>>>>>..>>>>>> .....................................................((((((()))))))...............((((((.(((((.............)))))..)))))) Human post-catalytic P complex spliceosome; U2 snRNA 6qdv 5 75 3.3 RF00020 URS0000118C49_9606 30705154 0000244,0000353 0005682,0046540 9606 guuucucuucagaucgcauaaaucuuucgccuuuuacuaaagauuuccguggagaggaacaaccaauuuuuugag <<<<<<<<<<<........<<<<<<<<...........>>>>>>>>...>>>>>>>>>>>............... (((((((((((...((...((((((((.(.......).)))))))).)))))))))))))............... Human post-catalytic P complex spliceosome; U5 snRNA 6qdv 6 97 3.3 RF00026 URS000035C796_9606 30705154 0030621 0000244,0000353 0005688,0046540 9606 gugcucgcuucggcagcacauauacuaaaauuggaacgauacagagaagauuagcauggccccugcgcaaggaugacacgcaaauucgugaagcguu <<<<<.<......>>>>>>.....................................<<...<<<.....>>>....>>................... (((((.((....))))))).....................................((..((((.....)))..).))................... Human post-catalytic P complex spliceosome; U6 snRNA 6qdv E 14 3.3 30705154 10515 ggccuccgaacgcu .............. .............. Human post-catalytic P complex spliceosome; Ligated exons: MINX mRNA 6qdv I 42 3.3 30705154 10515 guaagagccuagcauguagaaugaugucauacuuauccucag .......................................... .......................................... Human post-catalytic P complex spliceosome; Intron lariat: MINX RNA 6qdw a 118 2.83 RF00001 URS0000049E57_469008 33149120 0003735 0005840 469008 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<..<..<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>.>...>>. ((....(((.....((((((((....(((.(((...(.....)...)))...)))...)))))).)).((.......((((((((...)))))))).......))...)))....)). Cryo-EM structure of the 50S ribosomal subunit at 2.83 Angstroms with modeled GBC SecM peptide; 5S rRNA 6qdw b 2888 2.83 RF02540,RF02541 URS0000051AF4_469008 33149120 0003735 0005840 469008 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacagugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgauguggaaggccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugugaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcggcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccggccuugaaauaccacccuuuaauguuugauguucuaacguuggccccugaucgggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacuccuugagaguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuaac ..<...<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<.>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<...........>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<....<........<..<...<....<<.........>>....>..........<........>....>..>....>......>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<........>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<.<..<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>......>>.>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<<.<<.>>..>>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<..<<..............<<.....................................................>>.....>>..>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>.>.. ..(...((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...(((..((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))........((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((.))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((...(((((((((.....(((...(((.((((...(..................)...)))).)))..)).).....)))))).)))...))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((...(......{.(.......(...(...........)...)..........((........))......)....)...)..)).))...........]]].)...))))))))))...)))))))(((((((........)))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((..((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((((....((...((((....((((..(((..(((((((((((....{{{...))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((........)))...))))))...)))...))))(..).....))))...)).......).)))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((.))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((........(..........((....(.................................)..............)).)........)))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).((......)).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))).).. Cryo-EM structure of the 50S ribosomal subunit at 2.83 Angstroms with modeled GBC SecM peptide; 23S rRNA 6qdw v 75 2.83 RF00005 URS00004CF48A_469008 33149120 0030533 0006412 469008 gcgggcaucguauaauggcuauuaccucagccuuccaagcugaugaugcggguucgauucccgcugcccgcucca ..<<.....<............>..<...............>.....<<<<<.......>>>>>..>>....... ................................................((((.......))))............ Cryo-EM structure of the 50S ribosomal subunit at 2.83 Angstroms with modeled GBC SecM peptide; glycine-tRNA glyT 6qik A 3146 3.1 RF02540,RF02543 URS000061F377_4932 31115337 0003735 0005840 4932 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucgggucgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauagaggguguagaauaagugggagcuucggcgccagugaaauaccacuaccuuuauaguuucuuuacuuauucaaugaagcggagacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuacgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu .........................<<<<<.....<......>......>>>>>...........<<....>>..<<<<<......<<.....>>.....>>>>>..<<<..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<.<<<<<...<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>.......>>>>>>>>>>>........<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<<.....<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<..........>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<..........<.......<<<<<<.....>>>>>>....>..........>>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<........<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>....>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>.........<<..............>>.....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<<....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..[[[..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<<....>>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>.........>>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<.<<<<<<<<<<.....>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<..<<<....<<<<<....>>>>.>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<..<<<<<<<<<<<<<<................<...<<....>>............>........>>>>.>>>>>>>>>>...<<<<<.....<<<<.................<<<<<......>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))......<<<<<<<..<<<<.))))))>>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<....<<<<<<<<<.]]]..>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<.....<<..........<<<<<<.....>>>>>>......>>.......<...>..............>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<.<..<<<<<......>>>>>..>>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((..((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))).).....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((......(((..........))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((((((((((...(((.(((((((.....((...........((......(..(((.....)))..)....).)........).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.(((((((.(........(((((.(((...((.........))...))).....(...((......)).).)))))....).))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))((((((((((.((......((((.((((....))))))))...)))))))))).)).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))...........(.(........)..)......))....))...(((((........)))))]]((((..(((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((((.....))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..((((((.(((.((.................(...((....))............).........))..))).))))))...(((((.....((((.............>...(((((......)))))..))))..))))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......(..(.(.((.(((...((.......))...))).))...))...)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.............))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......(...).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Cryo-EM structures of Lsg1-TAP pre-60S ribosomal particles; 25S ribosomal RNA 6qik x 121 3.1 RF00001 URS000055688D_4932 31115337 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<....<<<.<<..............>>....>>...>>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Cryo-EM structures of Lsg1-TAP pre-60S ribosomal particles; 5S ribosomal RNA 6qik y 156 3.1 RF00002 URS00001BF64E_4932 31115337 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucau .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))................... Cryo-EM structures of Lsg1-TAP pre-60S ribosomal particles; 5.8S ribosomal RNA 6qn3 A 50 2.3 RF01704 URS0000EEACFE_1220 31216023 0070406 1220 cguucacccuucggggcgcaugaaaugggaguagggaacgggauucucau ......<<<....>>>........<<<<<<<<..........>>>>>>>> ......(((....)))........((((((((..........)))))))) Structure of the Glutamine II Riboswitch; RNA (51-MER) 6qn3 B 50 2.3 RF01704 URS0000EEACFE_1220 31216023 0070406 1220 cguucacccuucggggcgcaugaaaugggaguagggaacgggauucucau ......<<<....>>>........<<<<<<<<..........>>>>>>>> ......(((....)))........((((((((..........)))))))) Structure of the Glutamine II Riboswitch; RNA (51-MER) 6qnq 13 1506 3.5 RF00177,RF01959,RF01960 URS000080E226_300852 31175275 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggggucuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggaucacc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<.<.....>.>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>....<<<<.<<<<<....>>>>>.>>>>...<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>....<<<....>>>...>>>>>>>>..<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>....>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>........ .....(((...[.[[[...))).((((.(((((..((((((((.....(((.(((..(((..((.(.((.(((.....))).)).).)))))......(((......((((((((..((...(((((((.(((((....((((.(....).)))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).......(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..((((((((....((((((((....((((((....((........)).......))))))....).......((....)).)))))))...)))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((.....)))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((.(..(((((((.((......((........))..........(((((((..(....(((((((..(.(((((....))))).).....(.....).....))))))).).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.((((.((.......(((.....)))......))).))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))...))..))))))).(...((((((......(((..(...((((....))))...)....)))......))))))......(....(((((((........)))))))....)..)..).))).....(((((((..........)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}....... 70S ribosome initiation complex (IC) with experimentally assigned potassium ions; 16S ribosomal RNA 6qnq 1K 65 3.5 RF00005 URS000041AF00_83333 31175275 0030533 0006412 83333 ggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccc <<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>> (((..((((......[..)))).(((((.......))))).....(((((..]....)))))))) 70S ribosome initiation complex (IC) with experimentally assigned potassium ions; E. coli tRNAfMet 6qnq 2K 77 3.5 RF00005 URS000041AF00_83333 31175275 0030533 0006412 83333 cgcggggnggagcagccuggnagcucgucgggnucauaacccgaagnucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... 70S ribosome initiation complex (IC) with experimentally assigned potassium ions; E. coli tRNAfMet 6qnq 3K 77 3.5 RF00005 URS000041AF00_83333 31175275 0030533 0006412 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>......<<<<.......>>>>.>>>>>>..... .((..((..((((.........))))..((((.......))))......(((((.......)))))))..))..... 70S ribosome initiation complex (IC) with experimentally assigned potassium ions; E. coli tRNAfMet 6qnq 4K 17 3.5 31175275 83333 gguaaaaaugaaaaaaa ................. ................. 70S ribosome initiation complex (IC) with experimentally assigned potassium ions; mRNA 6qnq 1H 2879 3.5 RF02540,RF02541,RF00002 URS0000868533_300852 31175275 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaacgaaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggauguuggcuuagaagcagccaucauuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucuu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.....>>>>>>.>>....<<<<<.....<<....>>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...........>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<....<<...<<<<<<<<...<<<<<<......>>>>>>...>>>>>>>>..>>.....>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<....<<<.......>>>....>>.........<........>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<..<<<<<<<<..<<.......>>>..>>>>>>>...>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>...<<<..>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>. (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((.(((((....))))).))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....()....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((...((.(((......))).))...)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......((((.........(.........)............(..............)..))))...)))))))))).))..........]]].)....))))))))))...)))))))(((((((.......)))))))....))))))(((((((...(((......(((((.(((....))))))))...)))..))))).)).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((.((((((((..((.....)).)))))).....)).))))))..)))(...(((..))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(........((((....(.{..).....)))).((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........((.((..(((......((((((((....))))))))...)))............)).))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(..(.(..).).....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))...)))). 70S ribosome initiation complex (IC) with experimentally assigned potassium ions; 23S ribosomal RNA 6qnq 16 120 3.5 RF00001 URS00005AB4A7_300852 31175275 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> (((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).))))))))))) 70S ribosome initiation complex (IC) with experimentally assigned potassium ions; 5S ribosomal RNA 6qnq 1G 1510 3.5 RF00177,RF01959,RF01960 URS000080E226_300852 31175275 0003735 0005840 300852 guuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggggcuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggaucaccuccu ......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<..>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>....<<<<.<<<<<....>>>>>.>>>>...<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<.<..<<<<<<<.<..<<<......>>>.....>.>>>>>>>...>.......<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<<....>>>>..>>>>>>>>..<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<...<<...<<<.....>>>.>>....>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>....>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>............ ......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(.((((.((())).)))).).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..((((((((....((((((((....((((((....((........)).......))))))....).......((....)).)))))))...)))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((.(((((...))))).))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((.(..((((((((((......((........))..........(((((((..(...((((..((..(((((........)))))....(((....)))...))..))))).((.(((...((((((......(((((((((....)))...(((......)))...)))))).....((((.((((((...(....(((.....)))..)....)))))).....(((((....)))))........)))).......).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(....(((....)))....)....))).....)))))))......(....(((((((........)))))))....)..)..).))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... 70S ribosome initiation complex (IC) with experimentally assigned potassium ions; 16S ribosomal RNA 6qnq 2L 77 3.5 RF00005 URS000041AF00_83333 31175275 0030533 0006412 83333 cgcggggnggagcagccugguagcucgucgggnucauaacccgaagnucgucggnucaaauccggcccccgcaacca .<<<<<...<<<<.........>>>>.<<<<<.......>>>>>......<<<<.......>>>>..>>>>>..... .(((((...((((.........)))).(((((.......))))).....(((((.......))))).)))))..... 70S ribosome initiation complex (IC) with experimentally assigned potassium ions; E. coli tRNAfMet 6qnq 3L 77 3.5 RF00005 URS000041AF00_83333 31175275 0030533 0006412 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<.<...<<<<.........>>>>.<<<<<.......>>>>>.....<<<<.........>>>>.>.>>>..... .(((..(..((((.........)))).((((.........)))).....(((.(.......).))))..)))..... 70S ribosome initiation complex (IC) with experimentally assigned potassium ions; E. coli tRNAfMet 6qnq 4L 21 3.5 31175275 83333 aggagguaaaaaugaaaaaaa ..................... ..................... 70S ribosome initiation complex (IC) with experimentally assigned potassium ions; mRNA 6qnq 14 2879 3.5 RF02540,RF02541,RF00002 URS0000868533_300852 31175275 0003735 0005840 300852 caagaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggauguuggcuuagaagcagccaucauuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucuug <<<<.......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<..>>>>>>.>>....<<<<<.....<......>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<.....<<...<<<<<.<<<<.<<<....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>..>>>>>..>>.>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.......>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<....<<...<<<<<<<<.....<.<<......>>.>......>>>>>>>>..>>.....>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<.<<<.<<....<<.........>>....>>.........<........>...>>>.>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>.>..>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<<........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>.>>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<......<.......<<<<<<<<....>>>>>>>>....>................>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<<..<<.......>>>..>>>>>>...>>>>.>.......<<<<<.<.<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>...>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<.............>>>>....>>>.>>>>.......>>>>>>>...<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>.....>>>> ...........((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((..)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...(((((((.......)))))))....[.(((((((((......(...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)..)))))).))))....(((((((((.{.....)))))))))....]..((((}.[[[[))))...)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).......)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((.(((...(((...(((.((((......(.(......).).......)))).)))..)).)...))).)))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...(.([[[.....((((((.....(.....((..((((((((((.........(((...(...................)...........(.........)..))).....)))))))))).))..........]]].)....)))))).).)...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...(((((((((((((((..((.....)).)))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((.((.((((((..................((.......((((.(.(....).).))))....))...................)))))).)).))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.((((...........))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))...(((.))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))......... 70S ribosome initiation complex (IC) with experimentally assigned potassium ions; 23S ribosomal RNA 6qnq 1J 122 3.5 RF00001 URS00005AB4A7_300852 31175275 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga ..<<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> ..(.(((((((((....((((((((....(((.((...............))...)))...)))))).))(((.......((.(((((....))))).)).......))).))))))))).) 70S ribosome initiation complex (IC) with experimentally assigned potassium ions; 5S ribosomal RNA 6qnr 13 1516 3.1 RF00177,RF01959,RF01960 URS000080E226_300852 31175275 0003735 0005840 300852 uuuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggaucaccuccuu ......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<.<...>.>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<...<<<<<<......>>>>>.>...>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>....<<......>>...>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............. ......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(.((.((..((...))..)).)).).)))))......(((......((((((((..((...(((((((.(((((.....(((((....)))))......)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((.........)).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((((...(.((((....)))).)....((((....))))..))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((....(..(((.....)))).....)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}............ 70S ribosome elongation complex (EC) with experimentally assigned potassium ions; 16S ribosomal RNA 6qnr 1K 76 3.1 RF00005 URS00005AA258_83333 31175275 0030533 0006412 83333 gcccgganagcucagucgguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<.<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>.>>>.... ((...(......(.....[..)....((((.........)))).....(((((..]....))))).)...)).... 70S ribosome elongation complex (EC) with experimentally assigned potassium ions; E. coli tRNAPhe 6qnr 2K 76 3.1 RF00005 URS00005AA258_83333 31175275 0030533 0006412 83333 gcccgganagcucagncggnagagcaggggauugaanauccccgunnccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((.........)))).....(((((..]....)))))))))))).... 70S ribosome elongation complex (EC) with experimentally assigned potassium ions; E. coli tRNAPhe 6qnr 3K 76 3.1 RF00005 URS00005AA258_83333 31175275 0030533 0006412 83333 gcccggauagcucagucgguagagcaggggauugaanauccccguguccuugguucgauuccgaguccgggcacca .<<<.<<...<<<........>>>..<<<<<<.....>>>>>>.......<<.........>>..>>.>>>..... ((((.((...(((........)))...(((.........)).)........((.......))...)).)))).... 70S ribosome elongation complex (EC) with experimentally assigned potassium ions; E. coli tRNAPhe 6qnr 4K 30 3.1 URS0002335939_300852 31175275 83333 ggcaaggagguuuuuuuuuuuuuuuuuuuu .............................. .............................. 70S ribosome elongation complex (EC) with experimentally assigned potassium ions; mRNA 6qnr 1H 2890 3.1 RF02540,RF02541,RF00002 URS0000868533_300852 31175275 0003735 0005840 300852 ggucaagaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaacggccgaaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggauguuggagcagccaucauuuaaagagugcguuagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucuugacc .<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<[[<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.....>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...(((....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>.]]...............<<....>>....]].........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....<<..>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<.<..<<<<<......>>>>.>..>.>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<.......>...>>.........<<....>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..((((...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.........<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<.<<..<<<.......<<<<<<<....>>>>>>>....>>>............>>.>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<.(((..>>>>..)))>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<<..<<.......>>>..>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))))>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>>. .(((((((......((((((((((.....(((..((((((((((((......((((((.[[..[[[)))...].((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.....)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...((((((((.....))))))))....{.(((((((((...((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).))))....(((((((((.[.....)))))))))....}.(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....((()))....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((...(.(.((......)).)..)...)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......(((((..(...(.......)...)......(............).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((...........((.((..(.(.......(((((((....)))))).)...).)............)).))..))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.(((.......)))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))))))). 70S ribosome elongation complex (EC) with experimentally assigned potassium ions; 23S ribosomal RNA 6qnr 16 122 3.1 RF00001 URS00005AB4A7_300852 31175275 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga ..<<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> ..(((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).))))))))))) 70S ribosome elongation complex (EC) with experimentally assigned potassium ions; 5S ribosomal RNA 6qnr 1G 1513 3.1 RF00177,RF01959,RF01960 URS000080E226_300852 31175275 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggaucaccuccuuu .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<<..>>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<.<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<.<....>.>>>>>....<<......>>...>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<...<<<.....>>>.>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>..>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.............. .....((((..[.[[[..)))).((((.(((((..((((((((.....(((.(((..(((..((.((((.(((((..))))).)))).)))))......(((......((((((((..((...(((((((.(((((....((((.(....).)))).....))))).....(((.(((((....))))).)))....((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).......(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((.(((...))).))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((((.(....).)))))...((((....))))...)))))))).((.(((....(((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((....(..(((.....)))).....))))))).....(((((....)))))........)))).....).).)))...)..)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}............. 70S ribosome elongation complex (EC) with experimentally assigned potassium ions; 16S ribosomal RNA 6qnr 1L 76 3.1 RF00005 URS00005AA258_83333 31175275 0030533 0006412 83333 gcccggauagcucagucgguagagcaggggauugaanauccccguguccuuggnucgauuccgaguccgggcacca .<<<<<.....<<........>>...<<<<<<.....>>>>>>.....<<<<<.......>>>>>.>>>>>..... (..........((........).)..((((.........)))).....(.(((.......))).)......).... 70S ribosome elongation complex (EC) with experimentally assigned potassium ions; E. coli tRNAPhe 6qnr 2L 76 3.1 RF00005 URS00005AA258_83333 31175275 0030533 0006412 83333 gcccgganagcucagncgguagagcaggggauugaanauccccgunnccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((.........)))).....(((((..]....)))))))))))).... 70S ribosome elongation complex (EC) with experimentally assigned potassium ions; E. coli tRNAPhe 6qnr 3L 76 3.1 RF00005 URS00005AA258_83333 31175275 0030533 0006412 83333 gcccggauagcucagucgguagagcaggggauugaanauccccguguccuugguucgauuccgaguccgggcacca .<<<.<...<<<..........>>>.<<<<<<.....>>>>>>.....<<<<........>.>>>.>.>>>..... .((.(......((........))...((((.........)))).....((.((.......)).))..).))..... 70S ribosome elongation complex (EC) with experimentally assigned potassium ions; E. coli tRNAPhe 6qnr 4L 30 3.1 URS0002335939_300852 31175275 83333 ggcaaggagguuuuuuuuuuuuuuuuuuuu .............................. .............................. 70S ribosome elongation complex (EC) with experimentally assigned potassium ions; mRNA 6qnr 14 2876 3.1 RF02540,RF02541,RF00002 URS0000868533_300852 31175275 0003735 0005840 300852 ggucaagaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaacggcccgaaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggauguugaucauuuaaagagugcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucuugacc <<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<..>>>>>>.>>....<<<<<.....<......>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....<<...>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<.<........>.>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<..<<.......>>...............>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<....<<.......<<<<<<<<....>>>>>>>>....>>..............>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<.............>>>>....>>>.>>>>.......>>>>>>>..<<<<.....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>>> .(((((........((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((..)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))................)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((.....((..........))......)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[.....((((((.....(.....((..(((((((((......{..(((....(.....)...........()....))).....))))))))).))..........]]].)....)))))).)))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.(((((.....))))).))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((.((((((((.(.........((..(...........((....(.(..).)....))..................)..))).)))))))).)))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((....(.......)....))))))...)))).).)......((((.((((((..((((((((........)))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...))))).<.)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))...((.......)).....(((((((((.......)))))....((((((((..((....(((((....)))))...))..>))))).)))...))))......))))). 70S ribosome elongation complex (EC) with experimentally assigned potassium ions; 23S ribosomal RNA 6qnr 1J 121 3.1 RF00001 URS00005AB4A7_300852 31175275 0003735 0005840 300852 aucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<.....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>..>>>>>>>>>> .((((((((((.....((((((.(....(((((((...(.....)...))))..)))...).)))).))(((.......((.(((((....))))).)).......)))..)))))))))) 70S ribosome elongation complex (EC) with experimentally assigned potassium ions; 5S ribosomal RNA 6qt0 A 3164 3.4 RF02540,RF02543 URS000061F377_4932 31115337 0003735 0005840 4932 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauagaggguguagaauaagugggagcuucggcgccagugaaauaccacuaccuuuauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu .........................<<<<<.....<......>......>>>>>.....<.....<<....>>..<<<<<......<<.....>>.....>>>>>..<<<..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<<.<<<...<<.<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>.>>......>>.>>>>>>>>........<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>....>...........................<.<<....>>...>...........<<<<....>>>>..................................<<<<<.<<<<<<.....<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<........>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<......>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.........>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<........<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>....>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>............<..........>........>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..[[[..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<.<<<<<<<<<<......>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>.<.<<..<<<..<<<<<<....<<<....<<<<<....>>>>.>...>>>.>>>>..>>>>><<<<<.........>>>>>........<...........<<<<<.......>>>>>.....>.....>>.>..>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<..<<<<<<<<<<...<..<...........................................>.>.....>>>>>>>>>>...<<<<<.....<<<<..<<............>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))......<<<<<<<..<<<<.))))))>>>>>>>>>>>.........>>>>..>>>>>>.......<<.<...<<<<<<...<<.......>>...>>>>>>....>..>>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<....<<<<<<<<<<]]].>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<.....<<..........<<<<<.......>>>>>......>>.......<....>..............>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((..(((...(.((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))..)......))).))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((......((((........)))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((((((((((....((.(((((((.....(((....((...(.((((...((((((.....)))))).)))).)...))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.(((((((..........(((((.(((...((.........))...))).........((......))...)))))......))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))((((((((((.((......((((.((((....))))))))...)))))))))).)).....))))))((.....((.....((((((.......))))))((((.....((((..((...((((((...((.....)).))))))....[[(((.((...((....(((....)))..........((((........))))......))....))...(((((........)))))]]((((..(((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((((......))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..((.((((((.......(....................(..)....................).......)))))).))...(((((.....((((..(..............)...........>...((((((....))))))..))))..))))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((.(((((....{..)))).)))))(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.............))))...)))).))))....)))))))).......((((((.(((.......((.(........(((((((..).)))))).....))).......((..))................))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Cryo-EM structures of Lsg1-TAP pre-60S ribosomal particles; 25S rRNA 6qt0 x 121 3.4 RF00001 URS000055688D_4932 31115337 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Cryo-EM structures of Lsg1-TAP pre-60S ribosomal particles; 5S rRNA 6qt0 y 156 3.4 RF00002 URS00001BF64E_4932 31115337 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucau .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))................... Cryo-EM structures of Lsg1-TAP pre-60S ribosomal particles; 5.8S rRNA 6qtz A 3146 3.5 RF02540,RF02543 URS000061F377_4932 31115337 0003735 0005840 4932 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........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<.<<<<<...<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>>..>>>>.......>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<<.....<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<..........>>>.......>>>>>>.>>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<..<.<<<<....<<<<<.....>>>>>..>>>>.>..>>>..>>.>.....>>>>>...<<<<.<<<<.........>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<......<..........<<<.<<<<<<<<<........<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>....>>>>>>>>>>>>..........))).>....>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><<<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>.>>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>.........<................>.....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<<....<<<....>>>.......<<<<<<...<<<<.<<<<<<<<<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<<....>>>>>>>>>>>>.>.>>>>>>>.>>>>.........>>>>>>.........>>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<.....>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<....<<<<<....>>>>.>...>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<.<<<<<<....................<<....>>.....................>>>>.>>.>>>>>>>...<<<<<.....<<<<.................<<<<........>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>..>>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<....<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<...>.............>>.>>>....>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<.<..<<<<<......>>>>>..>>>>>...>>>....>>>>.>>>>>..>>>>>.. 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Cryo-EM structures of Lsg1-TAP pre-60S ribosomal particles; 25S rRNA 6qtz x 121 3.5 RF00001 URS000055688D_4932 31115337 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<.....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<........<<<<<..<<....>>.>>>>>......>>>>>.>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Cryo-EM structures of Lsg1-TAP pre-60S ribosomal particles; 5S rRNA 6qtz y 156 3.5 RF00002 URS00001BF64E_4932 31115337 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucau .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))................... Cryo-EM structures of Lsg1-TAP pre-60S ribosomal particles; 5.8S rRNA 6qul A 2795 3.0 RF02540,RF02541 URS0000E60BAB_562 30948752 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggcuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcgcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugauugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<..>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<..>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<.>>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<..>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<....<<..>>.....>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<..<<....>>...>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<..>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>.(<<...<<<<<<<...<<<<<<.......>>>>>>.....<<)..(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((..))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(.((()))..)...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{..((((.(((..(((.........)))..))).....(...((......)).).))))....)))..))))).))...........]]].)...))))))))))...)))))))(((((((((.)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..(((((.((((((...{{{.).))))).((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..((()))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((((((()))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....((.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..))....(((((((....))).))))..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Structure of a bacterial 50S ribosomal subunit in complex with the novel quinoxolidinone antibiotic cadazolid; 23S rRNA 6qul B 120 3.0 RF00001 URS0000049E57_562 30948752 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Structure of a bacterial 50S ribosomal subunit in complex with the novel quinoxolidinone antibiotic cadazolid; 5S rRNA 6qw6 4 126 2.92 RF00015 URS0000E60BB1_9606 30975767 0017070 0000244,0000353 0005687,0046540 9606 nagcuuugcgcaguggcaguaucguagccaaugagguuuauccgaggcgcgauuugcuaauugaaaacuucccaauagccgugacgacuagucggcauuggcaauuuuugacagucucgagacugg ....................<<<<<.<<<.....<<.....>>..>>>>>>>>........................<<<<<<.<<<<..>>>>.>>>.>>>.........<<<<<<..>>>>>>. ...................(((((.(((.....((.....))..))))))))........................((((((.((((())))).))).))).........((((((())))))). Structure of the human U5.U4/U6 tri-snRNP at 2.9A resolution.; U4 snRNA 6qw6 6 42 2.92 RF00026 URS0000E60BBB_9606 30975767 0030621 0000244,0000353 0005688,0046540 9606 uuggaaaagauuagcauggccccugcgcaaggaugacauuuu .......................................... .......................................... Structure of the human U5.U4/U6 tri-snRNP at 2.9A resolution.; U6 snRNA 6qwl T 12 4.1 URS000197CF6A_11320 31485076 11320 ggccuuguuucu ............ ............ Influenza B virus (B/Panama/45) polymerase Hetermotrimer in complex with 3'5' cRNA promoter; 3' cRNA 6qwl W 14 4.1 URS000197CF64_11320 31485076 11320 agcaaaagcaggcc .<<....>>..... .((....))..... Influenza B virus (B/Panama/45) polymerase Hetermotrimer in complex with 3'5' cRNA promoter; 5' cRNA 6qx9 1 164 3.28 RF00003 URS000032B6B6_9606 30975767 0030627 0000395 0005685 9606 auacuuaccuggcaggggagauaccaugaucacgaaggugguuuucccagggcgaggcuuauccauugcacuccggaugugcugaccccugcgauuuccccaaaugugggaaacucgacugcauaauuugugguagugggggacugcguucgcgcuuuccccug ...........<<<<.<<<<<.<<<<<..........>>>>>>>>>>.<<<<...<<<.<<<<<..........>>>>>.>>>...>>>>.<<<<<<<<<.......>>>>>>.>>>.>>>>...............<<<<<<..<<<....>>>..>>>>>>. ............(((.(((((..((((..........)))).))))).((((...(((.(((((..........))))).)))...))))..(.((((((.......))))))..)..)))................((((((..(((....)))..)))))). Structure of a human fully-assembled precatalytic spliceosome (pre-B complex).; U1 snRNA 6qx9 6 53 3.28 RF00026 URS000035C796_9606 30975767 0030621 0000244,0000353 0005688,0046540 9606 uuggaaaagauuagcauggccccugcgcaaggaugacuucgugaagcgauuuu ..................................................... ..................................................... Structure of a human fully-assembled precatalytic spliceosome (pre-B complex).; U6 snRNA 6qx9 I 25 3.28 30975767 10515 gggugaguacgcuuucgugcugacc ......................... ......................... Structure of a human fully-assembled precatalytic spliceosome (pre-B complex).; AdML pre-mRNA 6qx9 2 94 3.28 RF00004 URS0000E60B66_9606 30975767 0045131 0000348 0005686 9606 cgcuucucggcuguaguaucuguucuuaucaguuuaauaucugauagauuuuuggagcaucgaccugguauugcaguaccuccaggaacggugc ...........................<<<<<.<....>.>>>>>...........<<<<<<.<<<<<.............>>>>>..>>>>>> ...........................(((((........)))))...........((((((.(((((.............)))))..)))))) Structure of a human fully-assembled precatalytic spliceosome (pre-B complex).; U2 snRNA 6qx9 4 126 3.28 RF00015 URS0000E60BB1_9606 30975767 0017070 0000244,0000353 0005687,0046540 9606 nagcuuugcgcaguggcaguaucguagccaaugagguuuauccgaggcgcgauuugcuaauugaaaacuucccaauagccgugacgacuagucggcauuggcaauuuuugacagucucgagacugg ....................<<<<<.<<<.....<<.....>>..>>>>>>>>........................<<<<<<.<<<<..>>>>.>>>.>>>.........<<<<<<..>>>>>>. ...................(((((.(((.....((.....))..))))))))........................((((((.((((())))).))).))).........((((((())))))). Structure of a human fully-assembled precatalytic spliceosome (pre-B complex).; U4 snRNA 6qyz D 69 4.6 RF00044 URS000080E166_10756 31147544 10756 auguguauguuggggauuaaacccugauugaguucagcccacauacuuuguugauugguugucaaucau .<<..<<<<.<<<<.........<<<........>>>>>>>>>>>.......<<<.....>>>...>>. .((..((((.(((..........((.(......).)).)))))))......((((.....))))..)). The cryo-EM structure of prohead RNA in bacteriophage phi29 prohead; the prohead RNA (71-MER) in bacteriophage phi29 6qyz A 69 4.6 RF00044 URS000080E166_10756 31147544 10756 auguguauguuggggauuaaacccugauugaguucagcccacauacuuuguugauugguugucaaucau .<<..<<<<.<<<<.........<<<........>>>>>>>>>>>.......<<<.....>>>...>>. .((..((((.(((..........((.(......).)).)))))))......((((.....))))..)). The cryo-EM structure of prohead RNA in bacteriophage phi29 prohead; the prohead RNA (71-MER) in bacteriophage phi29 6qyz B 69 4.6 RF00044 URS000080E166_10756 31147544 10756 auguguauguuggggauuaaacccugauugaguucagcccacauacuuuguugauugguugucaaucau .<<..<<<<.<<<<.........<<<........>>>>>>>>>>>.......<<<.....>>>...>>. .((..((((.(((..........((.(......).)).)))))))......((((.....))))..)). The cryo-EM structure of prohead RNA in bacteriophage phi29 prohead; the prohead RNA (71-MER) in bacteriophage phi29 6qyz C 69 4.6 RF00044 URS000080E166_10756 31147544 10756 auguguauguuggggauuaaacccugauugaguucagcccacauacuuuguugauugguugucaaucau .<<..<<<<.<<<<.........<<<........>>>>>>>>>>>.......<<<.....>>>...>>. .((..((((.(((..........((.(......).)).)))))))......((((.....))))..)). The cryo-EM structure of prohead RNA in bacteriophage phi29 prohead; the prohead RNA (71-MER) in bacteriophage phi29 6qyz E 69 4.6 RF00044 URS000080E166_10756 31147544 10756 auguguauguuggggauuaaacccugauugaguucagcccacauacuuuguugauugguugucaaucau .<<..<<<<.<<<<.........<<<........>>>>>>>>>>>.......<<<.....>>>...>>. .((..((((.(((..........((.(......).)).)))))))......((((.....))))..)). The cryo-EM structure of prohead RNA in bacteriophage phi29 prohead; the prohead RNA (71-MER) in bacteriophage phi29 6qzp L5 3773 2.9 RF02540,RF02543 URS0000E60B93_9606 29143818 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaanggaaaguugaaaagaacuuugaagngagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcggcccggcggaucuuucccgcgcgggggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcunggaaggcccggcggggaagguggcucgggggcccccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcncucuccccccucccggcgcgccggggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccgggggaggccacgcgcgcgucccccgaagagggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccnucuugnaacncggaccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgagggngcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuagnacccnanagauggugancuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauagnggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcagacccgacgcccgccacgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacnuuuggnaagcngaacuggcgcuncgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggaugncgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagcggcgggccggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguagunnnaaauauucaaacgagaacuuugaaggccgaaguggngaaggguuccaugugaacagnanuugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcnccgggccguacccauauccgcagcaggucuncaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagcnggauccguaacuucgggauaaggauuggcucuaagggcugggucggucgcggccggcgccuagcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugccnagugcucugaaugucanagugnagaaauucaaugaagcgcggguaaacggcgggaguaacnaugacucucuuaagguagcnaanugccucnucaucuaauuagugacgcgcaugaauggaugancgagauucccacugucccuaccuacuauccagcgaaaccacngncaagggaacgggcuuggnggaaucagcggngaaagaaganccuguugagcuugacucuagucuggcacggugaagagacaugagagguguagaauaagugggaggcccccggcgcccccccgguguccccgcgaggggcccggggcgggguccgccggcccugcgggccgccggugaaauaccacuacucugaucguuuuuucacugacccggngaggcgggggggcgagccccgaggggcucucgcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacugnggcgguacaccugucaaacgguancgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucungauuuucagnacgaauacagaccgugaaagcggggccunacgauccuucugaccuuuuggguuuuaagcaggangugucagaaaaguuaccacagggauaacuggcuuguggcggccangcguucauagcgacgucgcuuuuugauccuungaugucggcucuuccuaucauugugaagcagaauunaccaagcguungauuguucacccacuaauagggaacgugngcugggnuuagancgucgugagacagguuaguuuuacccuacugaugnuguguuguugccaugguaauccugcncaguacgagaggaaccgcagguncanacauuugguguaunugcuuggcugaggagccaauggggcgaagcuacnaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccggucccccgccgggguccgguncngagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu ..........................<<<<<.....<......>......>>>>>...........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>>..<<<<<<<<<....<<<.<<<<........<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>...>>>.>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<<<..<<<.<<<.......<.....<<<<.<<<..<<<....>>>>>>>>>>.>......>>>....>>>>>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<<<<<<<<<<<<<<<<<...<<..<<<....<<<<......<<<<<<<....>>>>>>>.......>>>>...>>>........>>>>>>..>>>>>>>>>>>....................<<<<<<.<<<<<<<............>>>>>>>.<<<<<<.<<<<.<<<<<<<<<<.<<<<<<.<<<<<.<...........>..>>>>>.>>>>>.>.>>>>>>>.>>>...>>>>..>>>>.>>..<<<<<<<<<<.....>>>>>>>>.>>....>>>>>>.....>>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<.<......>.>>>>>..<<<<<...<<<..<<<..[[....[[.>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<......................<<<.<<<<<<<<<...<<<....<<<....<<<.....<.............>...>>>....>>>..>.>>...>>>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<..........<<.<<.....................>>......................>>......>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<...........]]....]]............................>>>>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<..<<<<...........>>>>.>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<..<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<.<<<<<<<<<<<.......................>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<<..<<..................................................................<...........>................................>>...>>>>>>>>...<<<<<.....<<<<..<.....<<.....>>....>...............<<<<<<<<<<.......>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>><<<<....>>>>>>)))].....<<<<<<<..<<<..)))))).>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<.]]]..>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.....<<<<<<<.<<..<<<<....<<<........<<<<<.<<<<....>>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>..............>>>>..>>>>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<....<<<<<......>>>>>...>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((...((((((((.(.....).)))).)))).....)))....((((((((.....(((.((.....(....((((((((..({((((......)))))....[[(...).(((....}]])))...).))))))))....).))))....))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((....(((((((.(((.....(((((((((((..(((((((.......(.....((((.(((............))))))).)......))))...))))))))))))))......))).))).))))....(((((((((((((((((((((((...((..(((..(.((((......(((((((....))))))).......))))..))))........))))))..)))))))))))....................((((((.(((((((............))))))).((((((.((((.((((((((((..((.((.(.(....................).).)).))...))))))).)))...))))..)))).))..((((((((((.....)))))))).))..[.)))))).....))).)))))...)))))...)))))))).<((((........))))((((((....(((((((((((((..(((..(((((........))))..)..)))...((....))...(((((..........)))))..(((((...(((..(((..[.....[.[)))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((......................(((.((((((((....(((....(((..(.(((.......................))).)..)))..)).)....))))))...(((((((((.(......))))))))))....))))))))))))..))..((((..((((.....))))..))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.....{.(..((................................................))..)...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((...........]].....]]..............(...)........)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((..(((((((...((.....)).))))))....[[(((.((...(.....(((....)))..........((....((...(...)...))...)).......)....))...(((((........)))))]]((((....(((((...((((((......))))))..((((....)))...(...((((((...(((((((((((((((((((((((..{{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....(((((((.......))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).))).))).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.((((((((((....(.(.......)).........))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(..((......(((......)))......)))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.(((((((((.(((((((.........(....................................(.................)..............................................)..........)))))))...(((((.....((((.....................................((((((((((.......))))))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(..((..((((....{..))))..)).)(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......(....(.((((((...((.......))...))))))...)....)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a.))..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}}.)))))..)).))...))))...)))).((((...((((.....}.......))))...))))..)))...).)))))).....(((((((.((..((((.(..(((........(((((.((((....)))).))))).......)))...(((..((((.....(((.((.((((......)))).)))))....))))..)))...........)..))))..)))))))))(((((.(..(.......)..)....((.(((((((.((.....((((.(..(((((......)))))..)))))....))....)))).))).))..))))).. High-resolution cryo-EM structure of the human 80S ribosome; 28S rRNA (3773-MER) 6qzp L7 120 2.9 RF00001 URS000002B0D5_9606 29143818 0003735 0005840 9606 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu .<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>... (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. High-resolution cryo-EM structure of the human 80S ribosome; 5S rRNA (120-MER) 6qzp L8 156 2.9 RF00002 URS00004B2C76_9606 29143818 0003735 0005840 9606 cgacucuuagcggnggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<.<<.....>>>.....(.<<<......>>.............>>>..)...>>>....<<....>><<<<<<<<.......>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....)).(((((((.......)))))))..................... High-resolution cryo-EM structure of the human 80S ribosome; 5.8S rRNA (156-MER) 6qzp S2 1740 2.9 RF01960,RF01959,RF00177 URS0000E60BC9_9606 29143818 0003735 0005840 9606 uaccugguugauccugccaguagcaunugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuauggunccuunggucgcucgcuccucucccacuuggauaacugugguanuucuagngcuaauanaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgccccccguggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcnaauuacccacucccgacccgggganguagugangaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauancguauauuaaaguugcugcaguunaaaagcucguaguungaucuugggagcgggcguccccgcccucucggccggggcccgaagcguuuacuuugaaaaaanuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagancgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccacnaggaguggagccugcggcuuaauuugacncaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggcnguucuuaguugguggagcgauuugucugguuaauucngauaacgaacgagacucuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauunagucccugcccuuuguacacaccgnccgucgnuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggucggcccacggcccuggcggagcgcugagaagacggucgaacuugncuaucuagaggaaguaaaagucgnancaagguuucnguaggugnnccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<....<<....<<<<<..................<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<<.....>.>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<<......>>>>>>>>.>>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....<<.<<<.<<..<<....>>..>>..>>.>.>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<.......................<<.<.............>>>...<<<<<<.<.......<<...<.......>.<<<<.......>>>>...>>......>.>>>..>>>........<.<..<<<<<<<...............>>>>>>>..>.>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>.>.>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<......>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<.......>>>>.>>>>.....>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<...<<.....................>>.....>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..((....((((....((.............((.....((.(((.....))).))......))......)).((((...(..............)...))))((..(((((...(......)..)))))......)).(.((((.((((......))))))))).).)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).).....(..(...((.(((....))).)).....)..)....(.((..(...........)..))......)..((((([[....(.((((.....((..]])).......))))))))))..)))))).)))..[......(.([[...(.(.((...(((..(.......................((................))...((((((.(.......((..((.......)).(((.......)))....))......).)))..)))........(.((.(....(.................)....).)).)....)....(((.((...(...((((..(((.((((((((...((........))......)))))))).))).......((....))...))))..)...))..))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.((((......)))))))))).)..)))...((..]]))...))...].))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((...(...((((..((((((((((((.......)))).)))).....))))..))))..).....(((((.....)))))........)))....))).))).....).))))).....).)))))...)).)))).))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..((((.((...((((...................................))))...)).))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}........ High-resolution cryo-EM structure of the human 80S ribosome; 18S rRNA (1740-MER) 6qzp S6 75 2.9 RF00005 URS0000326EAC_9606 29143818 0030533 0006412 9606 agcagaguggcgcagcggaagcgugcugggcccauaacccagaggucgauggaucgaaaccauccucugcuacca <<<<<<<........................................<<<<<.......>>>>>>>>>>>>.... (((((((....(.........)....(..(.......)...).....((.............))))))))).... High-resolution cryo-EM structure of the human 80S ribosome; E site tRNA (75-MER) 6r47 A 50 3.1 URS0000EEAD22_28117 31017785 28117 ggccguucgggcggccauaaacagcccucagaccngaagcguggcguucc (((((<<<<<<)))))................>>>>>>............ [[[[[((((((]]]]]................))))))............ The structure of pistol ribozyme bound to magnesium; RNA (50-MER) 6r47 B 15 3.1 URS0000EEACED_28117 31017785 28117 ggaacgccgguggga ............... ............... The structure of pistol ribozyme bound to magnesium; RNA 6r5q 3 75 3.0 RF00005 URS0000EEACF4_4932 31246176 0030533 0006412 4932 gcccggauagcucagcuguagagcaucagacuuaaaaucugaggguccaggguucaagucccuguucgggcgcca <<<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((.(..((((....[..)))).(((((.......))))).....(((((..]....)))))).))))).... Structure of XBP1u-paused ribosome nascent chain complex (post-state); E-tRNA 6r5q 2 76 3.0 RF00005 URS0000EEAD1A_4932 31246176 0030533 0006412 4932 gcuuccguagugcagcggcuagcacguuaggcucauaaucuaaagguccuugguucgaaaccauccgggggcacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.......<<<.......>>>..>>>>>>>.... ((...((..((((....[...)))).((((.........)))).......(.(..]....).)..))...)).... Structure of XBP1u-paused ribosome nascent chain complex (post-state); P-tRNA 6r5q 5 3543 3.0 RF02540,RF02543 URS0000A7632C_9986 31246176 0003735 0005840 9986 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggaaauguggcguacggaagacccacuccccggcgccggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcgcgguccggccgugccggcggggcggaucucccgcucccgucggcgggggaccgccccccggccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggccccggcggggaagguggcccgggggccccggguguuacagccccgccccggcagcagcagcucgccgaaucccggggccgagggagcgagacccgugcgccgcgcucuccccccucgggggggccgggccaccccucccacggcgcgaccgcuggggcggacuguccagugcgccccgggcgggucgcgccgucgggcccggggggccacgcgucccccgcgagcgcacggggucggcggcgaugucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcuacgaaagccgccguggcgcaaugaaggugaaggccggcggcgcgccgccggccgaggugggaucccgaggccuuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcgaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccaaaguuucccucaggauagcuggcgcucuccgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcugguguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggaugguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgcuggcagucggcagagcgagaaagagaguggcgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucagccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcuggcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacguuuuuucacugacccggugaggcgggggggcgagccgggcucucgcuucuggcgccaagcgcccggccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauagcgccggagccucgguuggccucggauagccggucccccgccgggguccggugcggagagcccuucgucccgggaaacggggcggccggaaagggggccgcccucucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcugcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>>..<<<<<<<<<....<<<<<<<<.<<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>..>>>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<......>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<<....<<<<<<<.<<<<<.<<<<<<<.<<<<<<<<<......>>>>>>>>>>>>>>>>>>>>>>>>>...>>>.>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<<<<<<<<<<<<<<<<<...<<..<<<..<<<<<<<......<<<<<<<<.>>>>>>>>.......>>>>>>>..>>>.........>>>>>>..>>>>>>>>>>>.....<<.......>>.........<...<<<<<<..>>>>>>....<<<...<<.<<<<<<<<<<<<<<<<<<<<<<<.<<<<..>>>>.>>>>>>.>>>.>>>>>>>>>>>.>>>...>>.>>.>................>........>>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<.....>>>>.....>>>...<<....>>...<<<<<<<<<<..>>>>>>>>>>..<<<<<...<<<..<<<...(((.[[.>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<...<<<.<<<<<<<<<...<<<....<<<..<.<<<..<<<<.<.........>.>>>>>>>.>..>>>..>>.>...>>>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<.....................>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<....................]].)))............>>>>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<<<<<...>>>>>>>>>>>......>>....>>...<<<<<........>>>>>))<<<<....<<<<<...<<<<<<<....>>>>>>>...<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<<<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>.>.>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<.>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<<....>>>>>>>>...<<<<<.....<<<<..<<.<<<<<>>.>>>>>..............<<<<<<<<<..>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))].....<<<<<<<..<<<..)))))).>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.<.....>.>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<]]].>>>>>..>>.>>...>>>>...>>>><<<<....<<<<<...........>>>>>....>>>>.>>>...>.>>>>>>.<<<<<<...<<<<....<<<........<<<<<..<<<<<.>>>>>.>>>>>.......>>>...<<<..<<<<....<<<<<<<<<........>>>>>>.>>>...>>>>..>>>..............>>>>....>>>>>>.<<<<<.<.............>....<<.<<<<<<<.<<.....<<<<.<..<<<<<.>>>>>..>>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..(((((((((((.....)))))).))))....))))....(((((((((....((((((((.(((((((((..({((((......)))))....[[(...).(((....}]])))...).)))))))..)))))))))...)))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...(((((((..(((.....((((((((((.(..(((((((.(((((.(((((((.((.(((((.(.()..)))))).))))))))))))))))))...))))))))))))))......)))..)).)))))...(((((((((((((((((((((((...((..(((..(((((((.......(((((((.)))))))........)))))))..))).........))))))..))))))))))).....((.....{.))...........(.((((((()))))))....(((...((.((((((((((((((((.((((((.((((..)))).))))))..)).))))))))))).)))...).))).)............[.)..........))).)))))...)))))...)))))))).<((((........))))((((((....(((((((((((((..(((..(((((.....))))..)..)))...((....))...((((((((((..))))))))))..(((((...(((..(((]...[[.[[[)))..)))....))))).(((((((((.((((......))))))))))).))....)))))))))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)<)))...(((..((.((.......B)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((...(((.((((((((....(((....(((..(.(((..(((.((..........)))))))).)..)))..)).)....))))))...(((((((((.(......))))))))))....))))))))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[.....(.(((((......(..........(((.((((((((((.....A.(((((.(((....(.........)....))).....(...((......)).).)))))...)))))))))))))..........]]].)....)))))).)))...)))))))((((((.(((........}.........].]].]].............)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...((..(.(((....))).....)....(..((((..(((...)))..)))).)......))....))...(((((........)))))]]((((....(((((...(((((((....)))))))..((((....)))...(...((((((...(((((((((((((((((.(((((...{{..))))).....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((.)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.(((((((((.(((((((......)))))))...(((((.....((((..(..(..(())...).)..............(((((.(((()))).)))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..b.))..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}..)))))..)).))...))))...)))).((((...((((.....a.......))))...))))..)))...).)))))).(((((.....(((....(((.........((((...((((.))))..))))........)))...(((..(((.....((..(((((........)))))...))....)))..)))..............)))......))))).(.(((.(..(.......)..)....((.(((((((.((.....((((.(..(((((.)))))..)))))....))....)))).))).))..))).).. Structure of XBP1u-paused ribosome nascent chain complex (post-state); 28S ribosomal RNA 6r5q 7 120 3.0 RF00001 URS000002B0D5_9986 31246176 0003735 0005840 9986 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. Structure of XBP1u-paused ribosome nascent chain complex (post-state); 5S rRNA 6r5q 8 151 3.0 RF00002 URS0000D56C3A_9986 31246176 0003735 0005840 9986 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcagguugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<<<<....>>>>.....<.<<<......>>........>>>..>...>>>....<<<..>>><<<<<<<<.......>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]]........)))..)...)))....((....))((((((((.......)))))))).................... Structure of XBP1u-paused ribosome nascent chain complex (post-state); 5.8S ribosomal RNA 6r5q K 1698 3.0 RF01960,RF01959,RF00177 URS0000EEACFB_9986 31246176 0003735 0005840 9986 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucguacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgcccggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcggccguccccugcucggcgccggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgaccccggucggcguaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggugcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<....<<....<<<...........<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<<<....>>>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<<.>>>>>>>>....>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<<..>>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....<<<<<<<<<.<<<....>>>..>>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<....<<<.<<<..>>>.>>><<<<<<<.<<..>>>>>>.>>>.<<<<<<.<.......<<...<.......>.<<<<.>>>>...>>......>.>>>..>>>........<.<<.<<<<<<<...............>>>>>>>.>>.>....>>....<<<<<<..<...<<<<..<<<.<<<<<<<<...<<<......>>>......>>>>>>>.>>>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<..>>>>.>>>>>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<<<<<<<<<<<..>>>>>>>>>.>.>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..(.....(((.....(([...(.(....((.(((.....))).))......))......)).((((...((((((....))))))...))))((..(((((...(......)..)))))......)).(]((((..(((.))).)))))...)))....)).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).).....(((((((((.(((....)))..)))))).)))....(.(...(...........)...)......)..((((([[......((((.....((..]])).......)))).)))))..)))))).)))..[......(.([[...(.(.((...(((..(....(((.(((()))).))).((((((.((())))))).))..((((((.(.......((..((.......)).(((.)))....))......).)))..)))........(.((.(((((((...............))))))).)).)....)....(((..(...(...((((..(((.((((((((...((........))......)))))))).))).......((....))...))))..)...)...))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.(((((....))))))))))).)..)))...((..]]))...))...].))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((..(((((......((........))..........(((((.(....(((((.....(..((..((........))..))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((...(...((((..((((((((((((..)))).))))))))..))))..).....(((((.....)))))........)))....))).))).....).))))).....).)))))...)).)))..))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..((((.((...(((((((((((.(((..))).))))).).)))))...)).))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}........ Structure of XBP1u-paused ribosome nascent chain complex (post-state); 18S ribosomal RNA 6r6g 2 75 3.7 RF00005 URS0000EEAD04_4932 31246176 0030533 0006412 4932 gcuuccguagugcagcggcagcacguuaggcucauaaucuaaagguccuugguucgaaaccauccgggggcacca <<<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.......<<<.......>>>..>>>>>>>.... .(..(((..((((.......)))).((((.........))))........((.......))...)))..)..... Structure of XBP1u-paused ribosome nascent chain complex with SRP.; P-tRNA 6r6g 3 75 3.7 RF00005 URS0000EEACF4_4932 31246176 0030533 0006412 4932 gcccggauagcucagcuguagagcaucagacuuaaaaucugaggguccaggguucaagucccuguucgggcgcca <<<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((.(..((((....[..)))).(((((.......))))).....(((((..]....)))))).))))).... Structure of XBP1u-paused ribosome nascent chain complex with SRP.; E-tRNA 6r6g 5 3543 3.7 RF02540,RF02543 URS0000EEAD05_9986 31246176 0003735 0005840 9986 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggaaauguggcguacggaagacccacuccccggcgccggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcgcgguccggccgugccggcggggcggaucucccgcucccgucggcgggggaccgccccccggccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggccccggcggggaagguggcccgggggccccggguguuacagccccgccccggcagcagcagcucgccgaaucccggggccgagggagcgagacccgugcgccgcgcucuccccccucgggggggccgggccaccccucccacggcgcgaccgcuggggcggacuguccagugcgccccgggcgggucgcgccgucgggcccggggggccacgcgucccccgcgagcgcacggggucggcggcgaugucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcuacgaaagccgccguggcgcaaugaaggugaaggccggcggcgcgccgccggccgaggugggaucccgaggccuuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcgaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccaaaguuucccucaggauagcuggcgcucuccgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcugguguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggaugguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgcuggcagucggcagagcgagaaagagaguggcgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucagccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcuggcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacguuuuuucacugacccggugaggcgggggggcgagccgggcucucgcuucuggcgccaagcgcccggccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauagcgccggagccucgguuggccucggauagccggucccccgccgggguccggugcggagagcccuucgucccgggaaacggggcggccggaaagggggccgcccucucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcugcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<<....<......>.....>>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..[[[..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>>..<<<<<<<<<....<<<<<<<<.<<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>..>>>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<......>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<<....<<<<<<<.<<<<<.<<<<<<<.<<<<<<<<<......>>>>>>>>>>>>>>>>>>>>>>>>>...>>>.>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<<<<<<<<<<<<<<<<<...<<..<<<..<<<<<<<......<<<<<<<<.>>>>>>>>.......>>>>>>>..>>>.........>>>>>>..>>>>>>>>>>>.....<<.......>>.........<...<<<<<<..>>>>>>....<<<...<<.<<<<<<<<<<<<<<<<<<<<<<<.<<<<..>>>>.>>>>>>.>>>.>>>>>>>>>>>.>>>...>>.>>.>................>........>>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<.....>>>>.....>>>...<<....>>...<<<<<<<<<<..>>>>>>>>>>..<<<<<...<<<..<<<...(((.[[.>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<<<...<<<....<<<..<.<<<..<<<<.<.........>.>>>>>>>.>..>>>..>>.>...>>>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>>>>>>.>>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<.....................>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<....................]].)))............>>>>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<.<<<...>>>.>>>>>>>......>>....>>....<<<<........>>>>.))<<<<....<<<<<...<<<<<<<....>>>>>>>...<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<<<<<<<<<<<<..{{{..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>.>.>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<.>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<<.<<<<<<<<....>>>>>>>>...<<<<<.....<<<<..<<.<<<<<>>.>>>>>..............<<<<<<<<<..>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..(((..>>>>>>.)))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.<.....>.>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]].....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<}}}.>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.<<<<<<...<<<<....<<<........<<<<<..<<<<<.>>>>>.>>>>>.......>>>...<<<..<<<<....<<<<<<<<<........>>>>>>.>>>...>>>>..>>>..............>>>>....>>>>>>.<<<<<.<.............>....<<.<<<<<<<.<<.....<<<<.<..<<<<<.>>>>>..>>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..(((((((((((.....)))))).))))....))))....(((((((((....((((((((.(((((((((..({((((......)))))....[[(...).(((....}]])))...).)))))))..)))))))))...)))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...(((((((..(((.....((((((((((.(..(((((((.(((((.(((((((.((.(((((.(.()..)))))).))))))))))))))))))...))))))))))))))......)))..)).)))))...(((((((((((((((((((((((...((..(((..(((((((.......(((((((.)))))))........)))))))..))).........))))))..))))))))))).....((.....{.))...........(.((((((()))))))....(((...((.(((((((((((((((((((((((.((((..)))).)))))).))).))))))))))).)))...).))).)............[.)..........))).)))))...)))))...)))))))).<(((..........)))((((((....(((((((((((((..(((..(((((.....))))..)..)))...((....))...((((((((((()))))))))))..(((((...(((..(..]...[[.[[[..)..)))....))))).((.((((((.((((......))))))))))..))....)))))))))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)<)))...(((..((.((.......B)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((...(((.((((((((....(((....(((..(.(((..(((.((.(.....)..)))))))).)..)))..)).)....))))))...(((((((((.(......))))))))))....))))))))))))..))..((((.((.((.....)).)).))))....(((......)))...(((((((...((([[[.....(.(((((......(..........(((.((((((((((.....A.(((((..((....(.........)....))......(...((......)).).)))))...)))))))))))))..........]]].)....)))))).)))...)))))))((((((.(((........}.........].]].]].............)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...((..(.(((....))).....)....(..((((.((((...))).))))).)......))....))...(((((........)))))]]((((....(((((...(((((((....)))))))..((((....)))...(...((((((...(((((((((((((((((.(((((...{{..))))).....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((.)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(..(((.....((((....)))).....))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((.......(((.((((((..(((((.(((((((((.(((((((......)))))))...(((((.....((((..(.....(()).....)..............(((((.(((()))).)))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(.(((.(((((....{..)))).)))))(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))........((.(.(..(((((...((.......))...)))))....)).).)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..b.))..))).))))).....(((((..(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}..)))))..)).))...))))...)))).((((...((((.....a.......))))...))))..)))...).).)))).((((((....(((....(((.........((((...((((.))))..))))........)))...(((..(((.....((..(((((........)))))...))....)))..)))..............))).....)))))).(((((.(..(.......)..)....((.(((((((.((.....((((.(..(((((.)))))..)))))....))....)))).))).))..))))).. Structure of XBP1u-paused ribosome nascent chain complex with SRP.; 28S ribosomal RNA 6r6g 7 120 3.7 RF00001 URS000002B0D5_9986 31246176 0003735 0005840 9986 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. Structure of XBP1u-paused ribosome nascent chain complex with SRP.; 5S ribosomal RNA 6r6g 8 151 3.7 RF00002 URS0000D56C3A_9986 31246176 0003735 0005840 9986 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcagguugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<.<<.....>>>.....(.<<<......>>........>>>..)...>>>....<<<..>>><<<<<<<<.......>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]]........)))..)...)))....((....))((((((((.......)))))))).................... Structure of XBP1u-paused ribosome nascent chain complex with SRP.; 5.8S ribosomal RNA 6r6g K 1698 3.7 RF01960,RF01959,RF00177 URS0000EEACFB_9986 31246176 0003735 0005840 9986 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucguacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgcccggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcggccguccccugcucggcgccggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgaccccggucggcguaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggugcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<....<<....<<<<..........<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<<<....>>>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<<.>>>>>>>>..>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<<..>>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....<<<<<<<<<.<<<....>>>..>>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<....<<<.<<<..>>>.>>><<<<<<<.<<..>>>>>>.>>>.<<<<<<.<.......<<...<.......>.<<<<.>>>>...>>......>.>>>..>>>........<.<<.<<<<<<<...............>>>>>>>.>>.>....>>....<<<<<<..<...<<<<..<<<.<<<<<<<<...<<<......>>>......>>>>>>>.>>>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<..>>>>.>>>>>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<.<<<<<<<<<..>>>>>>>>>...>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..((....(((.....(([...((.....((.(((.....))).))......))......)).((((...((((((....))))))...))))((..(((((...(......)..)))))......)).(]((((..(((.))).)))))...)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).).....(((((((((.(((....)))..)))))).)))....(.((..(...........)..))......)..((((([[......((((.....((..]])).......)))).)))))..)))))).)))..[......(.([[...(.(.((...(((..(....(((..((()))..))).((((((.((())))))).))..((((((.(.......((..((.......)).(((.)))....))......).)))..)))........(.((.(((((((...............))))))).)).)....)....(((..(...(...((((..(((.((((((((...((........))......)))))))).))).......((....))...))))..)...)...))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.(((((....))))))))))).)..)))...((..]]))...))...].))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((..((........))..))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((...(...((.(..((((((((((((..)))).))))))))..).))..).....(((((.....)))))........)))....))).))).....).))))).....).)))))...)).)))).))).(...((.(((........(.......((..((((....))))..))....).........))).))......(.....(((((..........))))).....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..((((.((...(((((((((((.(((..))).))))).).)))))...)).))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}........ Structure of XBP1u-paused ribosome nascent chain complex with SRP.; 18S ribosomal RNA 6r6p 5 3662 3.1 RF02540,RF02543 URS000086853D_9986 31246176 0003735 0005840 9986 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcggcccggcggaucuuucccgcgcgggggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucggccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcgcucuccccccucccggcgccgccggggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccgggggaggggccacgcgcgcgucccccgaagagggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcacacgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcgugagccgggcguggaauggagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagcggcgggggcggcgcgcgcgcgcgcccgcccccggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcugggucggucgucggccggcgccuagcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacauguuuuuucacugacccggugaggcgggggggcgagccccgaggggcucucgcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccggucccccgcgggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcacgccguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>...{.....<<....>>..<<<<<<.....<<.....>>....>>>>>>..[[[..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>>..<<<<<<<<<....<<<<<<<<........<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>...>>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]....}.............................<<....>>...............<<<......>>>..................................<<<<<<<<..<<<......<<<<<<<<.<<<.....<<<<<<<<<<<...<<<....<<<<<.<<....<<<<.<<<..<<<<<>>>>>>>>>>>>>>>>.>>>......>>>.>>>>>>>>>>>......>>>.>>>.>>>>>..<<<<<<<..<<<<<<<<<<.<<<........<..<<<.<<<<......<<<<<..>>>>>.......>>>>.>>>.>...........>>>...>>>>>>>>>>....................<<<<<..<<<<<<<..<<<<<.>>>>>>>>>>>>...<.<<.<<<<.<<<<<<<<<<<<<<<<<<<<<<<<.<<<<....>>>>.>>>>>>>>>>.>>>>>>>>>>>.>>>...>.>>>..>>.>........<<<<<<<<.....>>>>>>>>........>>>>>.......>>.>>>>>....>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<<....>>>>>>>>..<<<<<...<<<..<<<...(((..[[.>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<............<<<<<<<<<...<<<....<<<..<.<<<...<<<.<.<.....>.>.>>>.>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<........>>>>>>>>>...>>...>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.......<.<<......>>.>.>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<...........]].))).......................<<<..>>>.......................>>>>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<<<<<...>>>>>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<...<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<<<<<<<<<<<<..{{{..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>.>.>>>>>>>>>>>>.........>>>>>>>..>..........>..>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<...............<<<<<....<....>.....>>>>><<.<<<<<<<<<<<...<<<<<<.>>>>>>........>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<..<<<.....<<<<....>>>>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<<.<<<<<<<<<<..>>>>>>>>>>...<<<<<.....<<<<..<<.<<<<<<....>>>>>>>>..............<<<<<<<<<<<.....>>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..(((..>>>>>>.)))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]].....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<}}}.>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>......<<<<<<.<<..<<<.....<<.........<<<<<..<<<<..>>>>.>>>>>........>>....<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>..............>>>..>>>>>>>>.<<<<<.<.............>....<<.<<<<<<<.<<.....<<<<....<<<<<......>>>>>...>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..(((((((((((.....)))))).))))....))))....((((((.((....((((((((.(......((((((((..({((((......)))))....[[(...).(((....}]])))...).)))))))..)))))))))...)).))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((......((((((((.(((.....(((((((((((...(((.(..(((((.((....((((.((...((((())))).)))))))))).)))..)...))).))))))))))).....).)).))).)))))..((((((((.((((.(((((.(((....(...(..(((.((((......(((((()))))).......)))).))).).........).)))...))))).))))....................(((((..((((((...(((((.))))).))))))...(.((.((((..(((((((((((((((((((((((.((((....)))).)))))))))).))))))))))).))....).)))..)).)........((((((((.....))))))))........)))))......))).)))))....)))...)))))))).[((((........))))((((((....(((((((((((((..(((..(((((........)))).)...)))...((....))...((((((((....))))))))..(((((...(((..(((...[[[..[[.)))..)))....))))).(((((((((.((((......))))))))))).))....)))))))))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((............(.((((((....(((....(((..(.(((...((.((.(.....)..)))).))).)..)))..)).)....))))))...(((((((((........)))))))))....)...)))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[.....(.(((((......(..........(((.(((((((((......{.((.(..(((....(.........)....))).....(...((......)).)..).))....))))))))))))..........]]].)....)))))).)))...)))))))((((((.(((...........]].]]]...(................)..(((..))).......................)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...((..(.(((....))).....)....((.((((...((...))...))))))......))....))...(((((........)))))]]((((....(((.....(((((((....)))))))..((((....)))...(...((((((...(((((((((((((((((((((((...{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...))............))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((...((((((.))))))........)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(..(((.....((((....)))).....))))))))..)))))(((((.........)))))........((.(......).(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.(((((((((.(((((((.((..)).)))))))...(((((.....((((..(..((((((....)))))).)..............(((((((((((.....)))))))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(.(((.(((((....{..)))).)))))(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a.))..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}..)))))..)).))...))))...)))).((((...((((.....}.......))))...))))..)))...).))))))......(((((...(..(((.....((..........((((..((((())))).)))).........))....((..((((....((((.(((((((......)))))))))))...))))..))..............)))..)..))))).(((((.(..(.......)..)....((.(((((((.((.....((((.(..(((((......)))))..)))))....))....)))).))).))..))))).. Structure of XBP1u-paused ribosome nascent chain complex (rotated state); 28S ribosomal RNA 6r6p 7 120 3.1 RF00001 URS000002B0D5_9986 31246176 0003735 0005840 9986 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. Structure of XBP1u-paused ribosome nascent chain complex (rotated state); 5S ribosomal RNA 6r6p 8 156 3.1 RF00002 URS00004B2C76_9986 31246176 0003735 0005840 9986 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<.<<.....>>>.....(.<<<......>>.............>>>..)...>>>....<<<..>>><<<<<<<<.......>>>>>>>>.................... .........................................((((((.[[....[)))...].(.(((......]].............)))..)...)))....((....))((((((((.......)))))))).................... Structure of XBP1u-paused ribosome nascent chain complex (rotated state); 5.8S ribosomal RNA 6r6p 2 76 3.1 RF00005 URS0000EEAD1A_4932 31246176 0030533 0006412 4932 gcuuccguagugcagcggcuagcacguuaggcucauaaucuaaagguccuugguucgaaaccauccgggggcacca <<<<<<<..<<<<........>>>>.<<<.<.......>.>>>.......<<<.......>>>..>>>>>>>.... ((..(((..((......[.....)).((.............)).......(((..]....)))..)))..)).... Structure of XBP1u-paused ribosome nascent chain complex (rotated state); A/P-tRNA 6r6p 3 75 3.1 RF00005 URS0000EEACF4_4932 31246176 0030533 0006412 4932 gcccggauagcucagcuguagagcaucagacuuaaaaucugaggguccaggguucaagucccuguucgggcgcca <<<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((.(..((((....[..)))).(((((.......))))).....(((((..]....)))))).))))).... Structure of XBP1u-paused ribosome nascent chain complex (rotated state); P/E-tRNA 6r6p K 1698 3.1 RF01960,RF01959,RF00177 URS0000EEACE6_9986 31246176 0003735 0005840 9986 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucguacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgcccggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgauaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcggccguccccugcucggcgccggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgaccccggucggcguaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggugcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<....<<....<<<...........<<.....<<.<<.......>>.>>......>>.........<<<<...<<<<<<....>>>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<<.>>>>>>>>....>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....<<<<<<<<<.<<<....>>>..>>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<....<<<.<<<..>>>.>>><<<<<<<.<<..>>>>>>.>>>.<<<<<<.<.......<<...<.......>.<<<<.>>>>...>>......>.>>>..>>>........<.<..<<<<<<<...............>>>>>>>..>.>....>>....<<<<<<..<...<<<<..<<<.<<<<<<<<...<<<......>>>......>>>>>>>>.>>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<..>>>>.>>>>>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<<<<<<<<<<<..>>>>>>>>>.>.>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..((....(((.....(([...((.....((.(((.....))).))......))......)).((((...((((((....))))))...))))((..(((((...(......)..)))))......)).(]((((.((((.)))))))))...)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).).....(((((((((.(((....)))..)))))).)))....(.((..(...........)..))......)..((((([[......((((.....((..]])).......)))).)))))..)))))).)))..[......(.([[...(.(.((...(((..(....(((..((()))..))).((((((.((())))))).))..((((((.(.......((..((.......)).(((.)))....))......).)))..)))........(.(..(((((((...............)))))))..).)....)....(((.((...(...((((..(((.((((((((...((........))......)))))))).))).......((....))...))))..)...))..))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((..((..(.((((((.(((((....))))))))))).)..))....((..]]))...))...].))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((..(((((......((........))..........(((((.(....(((((.....(..((..((........))..))....).)))))...((.(((...(.((((((....(((.(((.(....).)..(.((......)))...)).)))....(((...(...((((..((((((((((((..)))).))))))))..))))..).....(((((.....)))))........)))....))).))).....).))))).....).)))))...)).)))..))).(...((.(((........(.......((..((((....))))..))....).........))).))......(.....(((((..........))))).....)..)..))))).....(.(((.((.......)).))).)......))...)))))))))).))..(.(..((.(..((((.((....((((.(((.(((..(.((.((...(((((((((((.(((..))).))))).).)))))...)).)).)..))).))).))))...)).))))...).))...)..)..(((((((((....)))))))))}........ Structure of XBP1u-paused ribosome nascent chain complex (rotated state); 18S rRNA 6r6p 4 10 3.1 31246176 9606 ccauuaauga .......... .......... Structure of XBP1u-paused ribosome nascent chain complex (rotated state); mRNA 6r7q 2 75 3.9 RF00005 URS0000EEAD04_4932 31246176 0030533 0006412 4932 gcuuccguagugcagcggcagcacguuaggcucauaaucuaaagguccuugguucgaaaccauccgggggcacca <<<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.......<<<.......>>>..>>>>>>>.... ....(((...(((.......)))..((((.........))))........((.......))...)))........ Structure of XBP1u-paused ribosome nascent chain complex with Sec61.; P-tRNA 6r7q 3 75 3.9 RF00005 URS0000EEACF4_4932 31246176 0030533 0006412 4932 gcccggauagcucagcuguagagcaucagacuuaaaaucugaggguccaggguucaagucccuguucgggcgcca <<<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((.(..((((....[..)))).(((((.......))))).....(((((..]....)))))).))))).... Structure of XBP1u-paused ribosome nascent chain complex with Sec61.; E-tRNA 6r7q 5 3543 3.9 RF02540,RF02543 URS0000EEACF2_9986 31246176 0003735 0005840 9986 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggaaauguggcguacggaagacccacuccccggcgccggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcgcgguccggccgugccggcggggcggaucucccgcucccgucggcgggggaccgccccccggccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggccccggcggggaagguggcccgggggccccggguguuacagccccgccccggcagcagcagcucgccgaaucccggggccgagggagcgagacccgugcgccgcgcucuccccccucgggggggccgggccaccccucccacggcgcgaccgcuggggcggacuguccagugcgccccgggcgggucgcgccgucgggcccggggggccacgcgucccccgcgagcgcacggggucggcggcgaugucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcuacgaaagccgccguggcgcaaugaaggugaaggccggcggcgcgccgccggccgaggugggaucccgaggccuuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcgaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccaaaguuucccucaggauagcuggcgcucuccgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcugguguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggaugguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgcuggcagucggcagagcgagaaagagaguggcgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucagccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcuggcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacguuuuuucacugacccggugaggcgggggggcgagccgggcucucgcuucuggcgccaagcgcccggccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauagcgccggagccucgguuggccucggauagccggucccccgccgggguccggugcggagagcccuucgucccgggaaacggggcggccggaaagggggccgcccucucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcugcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<<...<<<<<<<<<<<...>>>>>>>.>>>>.....>>>>>..<<<<<<<<<....<<<<<<<<.<<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>..>>>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<......>>>..................................<<<<<<<<..<<<.<....<<<<<<<<.<<<.....<<<<<<<<<<....<<<<<<<.<<<<<.<<<<<<<.<<<<<<<<<......>>>>>>>>>>>>>>>>>>>>>>>>>...>>>.>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<.<<<<<<<<<<.<<<<...<<..<<<..<<<<<<<......<<<<<<<<.>>>>>>>>.......>>>>>>>..>>>.........>>>>>>...>>>>>>>>>>.....<<.......>>.........<...<<<<<<..>>>>>>.....<<...<<.<<<<<<<<<<<<<<<<<<<<<<<.<<<<..>>>>.>>>>>>.>>>.>>>>>>>>>>>.>>>...>>.>>..................>.........>>.>>>>>....>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<.....>>>>.....>>>...<<....>>...<<<<<<<<<<..>>>>>>>>>>..<<<<<...<<<..<<<...(((.[[.>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<...<<<.<<<<<<<<<...<<<....<<<..<.<<<..<<<<.<.........>.>>>>>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<.....................>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<....................]].)))............>>>>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<<<<<...>>>>>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<...<<<<<<<....>>>>>>>...<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<.<<<<<<<<<<<.>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<<<..>>>>>>>>>...<<<<<.....<<<<..<<.<<<<<>>.>>>>>..............<<<<<<<<<..>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>><<<<....>>>>>>)))].....<<<<<<<..<<<..)))))).>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<]]].>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.<<<<<<...<<<<....<<<........<<<<<...<<<<.>>>>..>>>>>.......>>>...<<<..<<<<....<<<<<<<<<........>>>>>>.>>>...>>>>..>>>..............>>>>....>>>>>>.<<<<<.<.............>....<<.<<<<<<<.<<.....<<<<....<<<<<.>>>>>...>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..(((((((((((.....)))))).))))....))))....(((((((((....((((((((.(((((((((..({((((......)))))....[[(...).(((....}]])))...).)))))))..)))))))))...)))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....((((((((((.(..(((((((.(((((.(((((((.((.(((((.(.()..)))))).))))))))))))))))))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((..(((((((......((((((((.)))))))).......)))))))..))).........))))))..))))))))))).....((.....{.))...........(.((((((()))))))....(((...((.((((((((((((((((.((((((.((((..)))).))))))..)).))))))))))).)))...)).)).)............[.)..........))).)))))...)))))...)))))))).<((((........))))((((((..(.(((((((((((((..(((..(((((.....))))..)..)))...((....))...((((((((((()))))))))))..(((((...(((..(((]...[[.[[[)))..)))....))))).(((((((((.((((......))))))))))).))....)))))))))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)<)))...(((..((.((.......B)))).)))....))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((.(((((((...(((.((((((((....(((....(((..(.(((..(((.(..(.....)..).)))))).)..)))..)).)....))))))...(((((((((.(......))))))))))....))))))))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.....A.(((((.(((....(.........)....))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((........}.........].]].]].............)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...((..(.(((....))).....)....((.((((...((...))...))))))......))....))...(((((........)))))]]((((....(((((...(((((((....)))))))..((((....)))...(...((((((...(((((((((((((((((((((((...{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((.)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))((.((.........)).)).........(..........(((((.......)))))..).......)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.(((((((((.(((((((.(()).)))))))...(((((.....((((..(..(..(())...).)..............(((((.(((()))).)))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..b.))..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}..)))))..)).))...))))...)))).((((...((((.....a.......))))...))))..)))...).)))))).(((((....((((....(((.........((((...((((.))))..))))........)))...(((..(((.....(...(((((........)))))....)....)))..)))..............)))).....))))).(((((.(..(.......)..)....((.(((((((.((.....((((.(..(((((.)))))..)))))....))....)))).))).))..))))).. Structure of XBP1u-paused ribosome nascent chain complex with Sec61.; 28S ribosomal RNA 6r7q 7 120 3.9 RF00001 URS000002B0D5_9986 31246176 0003735 0005840 9986 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. Structure of XBP1u-paused ribosome nascent chain complex with Sec61.; 5S ribosomal RNA 6r7q 8 151 3.9 RF00002 URS0000D56C3A_9986 31246176 0003735 0005840 9986 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcagguugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<<<<....>>>>.....<.<<<......>>........>>>..>...>>>....<<<..>>><<<<<<<<.......>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]]........)))..)...)))....((....))((((((((.......)))))))).................... Structure of XBP1u-paused ribosome nascent chain complex with Sec61.; 5.8S ribosomal RNA 6r7q K 1698 3.9 RF01960,RF01959,RF00177 URS0000EEACFB_9986 31246176 0003735 0005840 9986 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucguacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgcccggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcggccguccccugcucggcgccggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgaccccggucggcguaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggugcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<....<<....<<<...........<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<<<....>>>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<<.>>>>>>>>....>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....<<<<<<<<<.<<<....>>>..>>>>>>.>>>......<<..<...........>..>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<....<<<.<<<..>>>.>>><<<<<<<.<<..>>>>>>.>>>.<<<<<<.<.......<<...<.......>.<<<<.>>>>...>>......>.>>>..>>>........<.<<.<<<<<<<...............>>>>>>>.>>.>....>>....<<<<<<..<...<<<<..<<<.<<<<<<<<...<<<......>>>......>>>>>>>>.>>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<......<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<..>>>>.>>>>>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.......>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>............<<<<<..........>>>>>...........>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<<<<<<<<<<<..>>>>>>>>>.>.>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..((....(((.....(([...((.....((.(((.....))).))......))......))..(((...(((((......)))))...))).((..(((((...(......)..)))))......)).(]((((.((((.)))))))))...)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).).....(((((((((.(((....)))..)))))).)))....(.((..(...........)..))......)..((((([[......((((.....((..]])).......)))).)))))..)))))).)))..[......(.([[...(.(.((...(((..(....(((.(((()))).))).((((((.((())))))).))..((((((.(.......((..((.......)).(((.)))....))......).)))..)))........(.((.((((((.................)))))).)).)....)....(((..(...(...((((..(((.((((((((...((........))......)))))))).))).......((....))...))))..)...)...))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.(((((....))))))))))).)..)))...((..]]))...))...].))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((..((........))..))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((...(...((((..((((((((((((..)))).))))))))..))))..).....(((((.....)))))........)))....))).))).....).))))).....).)))))...)).)))).))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..((((.((...(((((((((((.(((..))).))))).).)))))...)).))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}........ Structure of XBP1u-paused ribosome nascent chain complex with Sec61.; 18S ribosomal RNA 6r84 3 121 3.6 RF00001 URS000055688D_4932 31189955 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Yeast Vms1 (Q295L)-60S ribosomal subunit complex (pre-state with Arb1); 5S rRNA 6r84 4 158 3.6 RF00002 URS00001BF64E_4932 31189955 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<(.....>>............).>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....)))....((.((((.....]]............).)))..).).)))....((.....))(((((((((....)))))))))..................... Yeast Vms1 (Q295L)-60S ribosomal subunit complex (pre-state with Arb1); 5.8S rRNA 6r84 B 76 3.6 RF00005 URS0000EEAD03_4932 31189955 0030533 0006412 4932 gggcguguggcguagucgguagcgcgcucccuuagcaugggagaggucuccgguucgauuccggacucguccgcca <<<<<....<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>..>>>>>.... ((.((.(..(((.....[....))).(((((.......))))).....(((((..]....)))))).)).)).... Yeast Vms1 (Q295L)-60S ribosomal subunit complex (pre-state with Arb1); tRNA-Ala 6r84 1 3316 3.6 RF02540,RF02543 URS0000EEAD2C_4932 31189955 0003735 0005840 4932 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguagugagagccuuggucagacgcagcgggcgugcuuguggacugcuugguggggcuugcucugcuaggcggacuacuugcgugccuuguuguagacggccuuggucuugcuacacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauagaggguguagaauaagugggagcuucggcgccagugaaauaccacuaccuuuauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<<....>>......>>>>>.>...{.....<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<........<<.<<<<<<...>>>>>>.>>........>....<<<<<<.<<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]....}.............................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<......<<<<<<<<<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<<..>>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>....>>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<<..<<<<<<.....>>>>>>>>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<<....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<.<<<........>.>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<<....>>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<<..............<<<<<.....<..>......>>>>><<.<<<<<<<<<<<.<<<<<......<..<<<......<....<<..<<<..<<<<.<<<<..<<<<<<<<..>>>>>>>>..>>>>.>>>>..>>>..>>.....>......>>>..>.....>>>>>.>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<...<<.....<<<<....>>>>.....>>.>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>....>>>.>>>>>>>..>>>>>>...>>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<.<<<.<<<.<<<...........<<<<<..<<....>>............>>>>>..>>>.>>.>>>>.>.>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<<...<<<<<<<<<<}}}.>>>>>..>>>>>..>>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>......<<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>.><<<<<.<.............>.....<<<<<<<<<.<<<....<<<<.<..<<<<<......>>>>>..>>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((.(((...))).)).))....)........((.(((.(((((.(.(((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))).).....)))))))).))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.(((((......(((((((((((((((((((((((.......(((((((......((((.(....).)))).......))))))).....))))).))))))))))........(((....)))....)))))))).....))))).))))).[((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((........)))).)))....))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.(((.....(((((.....)))))...))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......(((..((((....)))).)))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........(..(.(........)..).)....))....))...(((((........)))))]]((((..((((..(...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....)..)..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((.((((..((......(((...........((..(((..((.(.(.((.(.((.(((....))).)).).)).).).))..)))..))............))).....))..)))).)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))((((((.......))))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..((((..(.((....((...........(((((..((....))............)))))..)).....)))..).)))...(((((.....((((...(((........)))............>...((((((....))))))..))))..))))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))).)..(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(...((((((...((.......))...))))))....).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))....))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)((((....((((....((((((((((}}..)))))..)))))...))))...)))).((((...((((.....}.......))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...((.((.(..(((......)))..).)).)).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(((.((..)..).)))..)))))...)))....)))).)))))).))))).. Yeast Vms1 (Q295L)-60S ribosomal subunit complex (pre-state with Arb1); 25S rRNA 6r86 3 121 3.4 RF00001 URS000055688D_4932 31189955 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Yeast Vms1-60S ribosomal subunit complex (post-state); 5S ribosomal RNA 6r86 4 158 3.4 RF00002 URS00001BF64E_4932 31189955 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....)))....((.((((.....]]............).)))..).).)))....((.....))(((((((((....)))))))))..................... Yeast Vms1-60S ribosomal subunit complex (post-state); 5.8S ribosomal RNA 6r86 1 3260 3.4 RF02540,RF02543 URS0000EEAD09_4932 31189955 0003735 0005840 4932 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........................<<<<<<.....<......>......>>>>>.>...<.....<<....>>..<<<<<......<<.....>>.....>>>>>..<<<..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<.<<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>....>.............................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<<.....<<<<<<<<<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<<..>>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>....>>>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<<..<<<<<<.....>>>>>>>>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>..>.....>>>>>><<<....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<.<<...........>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>...<...<<<<<<...<<<<.<<<<<<<<<<<<<<<<<<..[[[..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>.>.>>>>>>>.>>>>.........>>>>>>...>......>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<<........<.....<<<<<.....<..>......>>>>><<.<<<<<<<<<<<.<<<<<<......<.<<<.....<<......>>.....>>>..>....>>>>>>......>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<...<<....<<<<<....>>>>.>...>>.>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>.>>>.>>>>>>>..>>>>>>...>>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<..<<<<.<<<.<<<.<<<...........<<<<<..<<....>>............>>>>>..>>>.>>.>>>>.>.>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))......<<<<<<<..<<<<.))))))>>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>..>>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<<...<<<<<<<<<<]]].>>>>>..>>>>>..>>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>......<<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>.><<<<<.<.............>.....<<<<<<<<<.<<<....<<<<.<..<<<<<......>>>>>..>>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((.(((((((((((.(((...({((((......)))))[[(...).(((....}]])))....))).))))..))))))).....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((......((((.(....).)))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((........)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.(((.(...(((((.....)))))..)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.......(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...((((((...((.....)).))))))....[[(((.((...((....(((....)))........(..(.(........)..).)....))....))...(((((........)))))]]((((..(((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((..{{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((.((((..((....(.((......................))..)..))..))))......)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.....((.....((((....)))).....))..))))..)))))((((((.......))))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..((.(..(.((....((...........(((((..((....))............)))))..)).....)))..)..))...(((((.....((((..((((........))))...........>...((((((....))))))..))))..))))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(...((((((...((.......))...))))))....).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))....))..))).)))))....((((((((..(((..(.(((((......(....).....))))).)((((....((((....((((((((((}}}.)))))..)))))...))))...)))).((((...((((.............))))...))))..)))....)))))))).......(.((((.(((.((....((.(........(((((((..).)))))).....))).......((.(((...((.((.(..(((......)))..).)).)).))).)).............)).))).)))).)..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(((.((..)..).)))..)))))...)))....)))).)))))).))))).. Yeast Vms1-60S ribosomal subunit complex (post-state); 25S ribosomal RNA 6r87 3 121 3.4 RF00001 URS000055688D_4932 31189955 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((.(((...(....)...)))....))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Yeast Vms1 (Q295L)-60S ribosomal subunit complex (pre-state without Arb1); 5S rRNA 6r87 4 158 3.4 RF00002 URS00001BF64E_4932 31189955 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Yeast Vms1 (Q295L)-60S ribosomal subunit complex (pre-state without Arb1); 5.8S rRNA 6r87 B 76 3.4 RF00005 URS0000EEAD03_4932 31189955 0030533 0006412 4932 gggcguguggcguagucgguagcgcgcucccuuagcaugggagaggucuccgguucgauuccggacucguccgcca <<<<<....<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>..>>>>>.... ((.((.(..(((.....[....))).(((((.......))))).....(((((..]....)))))).)).)).... Yeast Vms1 (Q295L)-60S ribosomal subunit complex (pre-state without Arb1); tRNA-Ala 6r87 1 3316 3.4 RF02540,RF02543 URS0000EEAD2C_4932 31189955 0003735 0005840 4932 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguagugagagccuuggucagacgcagcgggcgugcuuguggacugcuugguggggcuugcucugcuaggcggacuacuugcgugccuuguuguagacggccuuggucuugcuacacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauagaggguguagaauaagugggagcuucggcgccagugaaauaccacuaccuuuauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu .........................<<<<<.....<......>......>>>>>.....{.....<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<........<<.<<<<<<...>>>>>>.>>........>....<<<<<<.<<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]....}.............................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<......<<<<<<<<<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<<..>>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>....>>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<...<<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>>.<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<<..<<<<<<.....>>>>>>>>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<......<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>....>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<.<<........>.>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<<<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>.>.>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<...............>>>>><<.<<<<<<<<<<<.<<<<.......<..<<<......<...<<<..<<<..<<<<.<<<<..<<<<<<<<..>>>>>>>>..>>>>.>>>>..>>>..>>.>...>......>>>..>......>>>>.>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.....<<....<<<<<....>>>>.>...>>..>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<.<<<.<<<.<<<...........<<<<<..<<....>>............>>>>>..>>>.>>.>>>>.>.>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<<...<<<<<<<<<<}}}.>>>>>..>>>>>..>>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<.<..<<<<<......>>>>>..>>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((.(.(((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))).).....)))))))))))...)....(((((((........)))))))......((((..[[[[[[))))...)))..................................((....))............(..((((....))))............).....................(((((.(((((......(((((((((((((((((((((((.......(((((((......((((.(....).)))).......))))))).....))))).))))))))))........(((....)))....)))))))).....))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((........)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.(((.....(((((.....)))))...))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........(..(.(........)..).)....))....))....((((........)))).]]((((..((((..(...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....)..)..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((.((((..((....(.(((...........((..(((..((.(.(.((.(.((.(((....))).)).).)).).).))..)))..))............)))..)..))..)))).)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))((((((.......))))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..((((..(.((....((...........(((((..((....))............)))))..)).....)))..).)))....((((.....((((..(((..........)))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))....))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)((((....((((....((((((((((}}..)))))..)))))...))))...)))).((((...((((.....}.......))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(((.((..)..).)))..)))))...)))....)))).)))))).))))).. Yeast Vms1 (Q295L)-60S ribosomal subunit complex (pre-state without Arb1); 25S rRNA 6ri5 A 3147 3.3 RF02540,RF02543 URS000061F377_4932 31115337 0003735 0005840 4932 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucgggucgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauagaggguguagaauaagugggagcuucggcgccagugaaauaccacuaccuuuauaguuucuuuacuuauucaaugaagcggagcacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuacgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu .........................<<<<<.....<......>......>>>>>...........<<....>>..<<<<<......<<.....>>.....>>>>>..<<<..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<.<<<<<...<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>>..>>>>.......>>>>>>>>>>>........<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<<.....<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<..........>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<..<.<<<<<..<<<<<<.....>>>>>>>>>>>.>..>>>..>>.>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<......<..........<<<.<<<<<<<<<........<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>....>>>>>>>>>>>>..........))).>....>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>.........<................>.....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<<....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..[[[..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<<....>>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>.........>>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<...............>>>>><<.<<<<<<<<<<.....>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<....<<<<<....>>>>.>...>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<..<<<<<<<<<<<<<<.................................................>>>>.>>>>>>>>>>...<<<<<.....<<<<..................<<<<<......>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))......<<<<<<<..<<<<.))))))>>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>..>>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<....<<<<<<<<<<]]].>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<...>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<.<..<<<<<......>>>>>..>>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((..((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))).).....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((......(((..........))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((((((((((....((.(((((((.....(((....(((..(.((((...((((((.....)))))).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.(((((((..........(((((.(((...((.........))...))).....(...((......)).).)))))......))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))((((((((((.((......((((.((((....))))))))...)))))))))).)).....))))))((.....((.....((((((.......))))))((((.....((((..((...((((((...((.....)).))))))....[[(((.((...((....(((....)))...........(.(........)..)......))....))...(((((........)))))]]((((..(((.(((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....)))...))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((((.....))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))((((((.......))))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..((((((..((((((................(...(.(...))............)........)))).))..))))))...(((((.....((((..............>...(((((......)))))..))))..))))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.............))))...)))).))))....)))))))).......((((...(((.((....((.(........((((((.....)))))).....))).......(...).............)).)))...))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Cryo-EM structures of Lsg1-TAP pre-60S ribosomal particles; 25S RNA 6ri5 x 121 3.3 RF00001 URS000055688D_4932 31115337 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<....<<<.<<..............>>....>>...>>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Cryo-EM structures of Lsg1-TAP pre-60S ribosomal particles; 5S rRNA 6ri5 y 156 3.3 RF00002 URS00001BF64E_4932 31115337 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucau .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))................... Cryo-EM structures of Lsg1-TAP pre-60S ribosomal particles; 5.8S rRNA 6rm3 S60 1231 3.4 RF02542,RF01960,RF01959,RF00177 URS0000EEACFA_6039 31332387 0003735 0005840 6039 accagguugauucugccugacguagacgcuauucccuaagauuaacccaugcauguuuuugauauggaaaaauggacugcucaguaauacucacuuuauuuaauguauuaaaguauaacugcguuaaaguguagcauaagacuauacaguaagagugagaccuaucagcuaguuguuaagguaauggcuuaacaaggcaaugacggguaacgguauuacuuuguaauauuccggagaaggagccugagagacggcuacuaagucuaaggauugcagcaggggcgaaacuugaccuauggauuuuaucugaggcaguuaugggaaguaauauauuguuucauauuguaaaaguauaugaggugauuaauuggagggcaaaucaagugccagcagccgcgguaauacuuguuccaagaguguguaugaugauugaugcaguuaaaaaguccguaguuuauauuuaagaagcaauaugagguguacuguauaguugggagagagaugaaaugugacgacccugacuggacgaacagaagcgaaagcuguacacuuguauguauuuuuugaacaaggacguaagcuggaggagcgaagaugauuagauaccauuguaguuccagcaguaaacuaugccgacgaugugauaugauauuaauuguauuagaugauagaaauuugaguuuuuuggcucuggggauaguaugaucgcaagauugaaaauuaaagaaauugacggaagaauaccacaaggaguggauugugcggcuuaauuugacucaacgcgagguaacuuaccaauauuuuauuauucagagaagauuaaucugagaaugauaauaguggugcauggccguuuucaauggaugcugugaaguugauuaauuucaacaagacgugagacccuuuuauuaauagacagacacaaucaguguaggaaggaaaggauuaaaacagguccguuaugcccucagacauuuugggcugcacgcgcaauacaauagauauauaaucuuuaugggauaauauuuuguaagagauauuugaacuuggaauugcuaguaaauuuuauuaaauaaguagaauugaaugugucccuguucuuuguacacaccgcccgucgcuaucuaagaugauauguguugugaaauuagugaaaacuacuugaacaauauguauuagaucugauaugucguaacaugguugcuguuggagaaccauuagcaggaucaua ..<<<<<.[.((((>>>>>.<<<<.<<<<..<<<<<.<<......<<<.<<<..<<<.<<........>>>>>......<<........<<<<<<<..<<...<<<<<....<<....<<<<<<....>>>>>>......>>.>>>>>..>>>>>>>>>.<<<....<<<...<<<<<<<.......>>>>>>>.>>>......>>>...<<<.<<<<<...>>>>>...>>>.>>.<<.<<<..........>>>.>>..<<<....>>>....>>>>>>......<<.<.<....<<<.....>>>..>.>>>>>..>>>>>..<<<..>>>....<<<<<.........>>>>>..........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>.>>>>..........<<<((.....<<<<...<<<........<<<<.<<...<..<<<<<<<<<..<<<<<<<<...<..........>......>>>>>>>.>.>>.......<<....>>.>>>>>>>.>..>>..>>>>..>>.>..>>>>..<.<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..>.......<<<.<<.<<.<<<<<<<<<....>>>>>>>>>.>>......)).....>>.....>>>.>>>.<<.......<<<<....>>>>.....>>..)))).]<<<<<.<<<<<<<..<<.<<..<<..<<<<<<<<<<......<<........>>..........<<<<.<<.<<<<<<<<<.....<<<<..>>>>..>>>>>>>>>.<<.<<<..<<.<<<<<<....<<<...<<<....>>><<<......>>>......>>>.....<<<<<<<<..>>>>....<<<<.....>>>>........>>>>.....>>>.>>>.....>>>>>>>.....>>.>>>>...>>.>>>>>>>>.....<<<<.....>>>>....<....<<<<<<<......>>>>>>>....>.....>>..>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<..<<<<......<<<<<<<<<<<<..<<.<<<<....>>>>.>>..>>>>>>>>>>>>......>>>>.>.>>..........<<<<.<<<....>>>.>>>>......... ..((((..[.[[[..)))).((((.((((..(((((.(((.....(((.(((..(((.((........)))))......(((.......(((((((..((...(((((....((....((.(..(...).).))......)).)))))..))))))))).(((....(((..((((((((.......)))))))))))......)))...(((..((((...))))....)))))).((.(((..........))).)).((((....))))...)))))).).....(.(.(...((((.....))).)).)).))..)))))..(((()))).(..(((((.........)))))........).((((([[....(.((((.....((..]])).......))))))))))..)))).))))...[......((([[.....((((.....(........((((.((..(((.((((((((((..((((.(.......................).))))..))).......((....)).)))))))))).))..)))..)).....))))....((((((...((...((((.........))))...))))))))......{...(((.((.((.(((((((((....))))))))).))...(..]])....))...].))).))).((.......((((....)))).....))...]]].](((((.(((((((..((..(.(((..((((((((((......((........))........(.((((.((.((((.(((.......(((())))....))).)))).((.(((...(.((((((....(((..((((....)))(((......)))...)..))).....((((.(((..)))..(..((((.....)))).....)..)))).....))).))).....).))))).....)).)))))..)).)))))))).(...((.........))....(....(((((.(......).)))))....)..)..))).).....((((.(((.......))).))))......))...)))))))))).))..(.(..((.(..((((..(..(((((((((((((..((.((((....)))).))..)))))))))))))..)..)))).).))...)..)..(((((.(((....))).)))))}....... Evolutionary compaction and adaptation visualized by the structure of the dormant microsporidian ribosome; 16S rRNA 6rm3 L70 118 3.4 RF00001 URS0000EEAD30_6039 31332387 0003735 0005840 6039 aguuacggccauaucuacuguaaaacaccggaacucgucagcucuccgaaguuaagccaguaagagccuugugaguacugagaugggagaccgcucggaaaagcaaggugcuguaauu <<<<<<<<.....<<<<<<<......<<<<<..............>>>..>>.....>>>>>.>><<<<<<<.....<<<<<..<<....>>.>>>>>....>>>>>>>.>>>>>>>> (.(((((((....(((((((......((((((...(....)...))))..)).....))))).))((((((......(((((..((....)).))))).....))))))))))))).) Evolutionary compaction and adaptation visualized by the structure of the dormant microsporidian ribosome; 5S rRNA 6rm3 L50 2313 3.4 RF02540,RF02543 URS0000EEAD15_6039 31332387 0003735 0005840 6039 uacccacacaugggaucaauaggauaccauaacgaugaaggucguaauagaauacgaaaguauuuaccuaauuaauauauuaauguauugauaacccuuugaacuuaagcauaucauuaaaaggaggaaaagaaacuaacuaggauuucuuuaguagcagcgagugaacaagaaauaacccuccauuguaauccuuaauuggaguuguaaaugguuuauucuauuaauuauuauagagaauauauucguuauuaauagaauagaauaauguacuugaguagagcugcuugguagugcaguuugaauaaagguagaaugaaauaucuaagguuaaauauaaugguauaccgauagaaaauaaguacugcgaaggaacuugugaaaauguguggaguuuagccuuauuuuuaaggacccgucuugaaacacggaccaaggagauuauaauuauagcaagauaaaaauaaucuuuauuaacuugauuaguuauaauuauaagacccgaaacacagugaacuauacauguucugguugaagauaagcaaguuuauuggaagaccauaaucauucugacgugcaaaucgaugauuuaagauguguauaguggcgaaagaccaaucgaacugugugguagcugguucacagcgaaaugucucucaggacagcaguuauuauuauauaggacauagauguaggacacuguuauaguuaacuaugagaaaucuuuaauucuauggaauuauauaaauuaaauuuauauaaugaaucuauuguauaacuagugggcacaugauuguaagaaugaugugcaaaaagggaugaaccuuaugaaacauuaaauauucuaaauaguagauauuauaccauaaauaugaugaauacauguauuauuguauaaaauggaagaagauuacuacuuuuaugagauguuucuaauauuuagguagcugugcaauuuguuuguauugaaguauauaugugaguauauauagaagaaacaaaugagccgaucuuggaggcaguaacaauauauguauagauauagacuaggguuuucaauuuauugaagugaaucgguguuauauaaaaacaaaaaagauuaauaauucuuuauuaaauuauuauaagguaacuugauaaugacaguauauuucaauaaauuuaagauaaaugaauuaaauuuuuaacuauggauugucaugauaagaaauaguuaauuauauauacuugauaaaaauaaaauaauuuuaaccguaccuauaccgcaucaggugucuuuguaucauaacaaauauuuuaaauuaaaguaaguaagggaauucggcaaauuagaucuguaacuuugggauaaagauuggcucuagcaugcuagaacuuuuacuauguaaggaaucugacuguuuauuaaaaacauagcuuuuuguauuuacaagaagugaauucugcccagugcauuuguuaaaguuguguaagcgaauguaaacggcgggaguacuaugacucucuuaagguagccaaaugccucgucauuuaauuggugacgcgcaugaauggagcaacgagauuccuacugucccuacuuacaauuuugugaaaccacgagacaagggaacgggcuuguuauuuaucagcggggaaagaagacccuguugagcuugacuuuaguauguuuuaauaaauauucgaauauuuauuuauuagaauauauggggaguuuggcuggggcgguacagcuguuaaaaaguaacacagcuguccuaagguagaugaaugauggaugguaaccaucaguuuauuauaagggaauaaaucugcuuuacuuuaugcauaugacuguauuuaguagggaaaccuuggccuagcgaucccaauuacauucauuauguauugggugauugaaaaguuaccacagggauaacuggcuuguagcaggcaagcgaucauagcgacucugcuuuuugauucuucgaugucgucucuucugaucaucguaguguauauguuacgaaguguuggauuguucacccgguaaugaggaacgugagauggguuuagaccgucgugagacagguuaguuuuacccuacuguaaguauuuuugagugaacuuugauaguacgagaggaacucuaagugaugaccacugguagugcgauuaacuauuaaguuauguugcuuagcuacgucguuucgauuaaggcugaaagccucuuaagccugaagcguagcucaaagauacauuuaggagaauacuacucuuuuaagcagaacuguaagaaugaagguguaugccgacauuuugagguuacugcuu .<<<<<<<<<<.....<<<..<<<<<<<<<..<.....<<<<<<<........>>>.........>>>>....<<<<<<<..>>>>>>>>....<<<<<<.....<......>......>>>>>.>.........<<....>>.<<<<<<<.....<<.....>>....>>>>>>>.<<<...........<<<......>>>...........<<<<<<<<<<<<<<.........<<<<..>>>>...>>>>>>>>>>>>>>................<<<<<<<........>>>>>>>......<<<<<.(((((..>>>>>..>>>........>>>>>>>.>>...............<<....>>....>>>.....>>>>>>>>.>>....<<<<<....>>>>>..<<<<........>>>>.<<<<<....<<<<<<<<<<<<<..<<<.......>>>...<......>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<.<<<<....<<<<<<<..>>>>>>>.....>>>>.<<<<..<<.<<........>>>>.>>>>...>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<.<<<<<<<<...<<<<...<..<<<<<<..>>>>>>..>..>>.>>...>>>>>>..<<<<<<<<.<......>>>>>>>>>...>>>>>.>.>>>>>>.>>..<<<<<<.<<<.....>>>.>>>>>>...<<<<......>>>>..<<<<<<<...<<<(((......<<<<..............<<<<<<<.<<<<<<>>>>>>>>>>>>>.........))).....>>>>...>>>...>>>>>>><<.....>>....>>>>>><.<<<<<<<<........<<<<<<<<....>>>>>>>>.....>>>>>>>>..>.....>>>>>.<<.....<<<<<<<....>>><<<<.<<<<..<<...<<<<<<..>>>>>>....((<<<<<<.........>>...<<<<<........>>>>>))<<<<<<<<...<<<....>>>.........<<<<<<<......<<<<<<<<....[[[...>>>>>>>><<<<<<<<...<<.....>>......>>>>>>>>....>>>>>>>.............>>>>>>.>>>>>>..>>....<<......>>.>>>><<<........>>>.>>>>..<<......<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<....>>>>>.>>...........<<<<<<<<<..<<<.........>>>..<<<<<<<........>>>>>>>...<<..<<<..<<<<<<<.<<<...........>>>.>>>>>..>>>>><<<<<<......>>>>>>........<...........<<<<<<.....>>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<<........>>>>>>......<<<..<<<.<<......<<<<.<<<<<<..<<<<..<<<<<<<..<<<<<<<<<<..>>>>>>>>>>......>>>>>>>...>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<..<<<<<......>>>>>..>>.<<<....>>>.>>)))].....<<<<<<.<<<.))))).>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>..>>.......<<<<<.<<<<<...<<<<<<<<<......>>>>>>>..>>.<<<.........>>>......>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>...<<<<<<<<<<<<..<<<<.<<...............>>.>>>>.<<<<<....<<<...<<<<<<<<<.]]]..>>>>.>>>>>...>>>..>>>>>..<<.<..<<<<<............>>>>>...>>>..>>>>>>>>>>>>.....<<<<.......>>>>....<<<<<<<<<....<<<<<..<<<....>>>..>>>>>...>>>>.>>>>>. .((((((((((.....(((..((((((((.(.(......((((((........))).........))).....(((((((()))))))))....(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........((((......)))....)......((((((((((((((.........((((..))))...))))))))))))))...........)....(((((((........)))))))......(((((.[[[[[..)))))..)))......)..)))))).))...............((....))....))).....)))))))).))....(((((....))))).[((((........)))).(((((..(.(((((((((((((..(((.......)))...(......).....)))))))))))))..((.(...((((((.....(((((((((.((((....(((((((..)))))))....[))))...((..((.((.......<)))).)).....))))))))).(.((.......))...)..))))))......).))).((((((....(((((....)))))((((((((......(((.((((((((....(((...(..((((((()))))))..)..)).)....))))))..((((((((.(......)))))))))...)))))...)))))).))..((((((.(((.....))).))))))....(((......)))...(((((((...((([[[...(.(((((...............((((((.(((((())))))))))))..........]]].....)))).)))))...)))))))((.....))....))))))(.((((((((.(......((((((((....))))))))...).))))))))..).....))))).((.....(((((((....)))((((.((((..((..(((((((..))))))....[[(((.((.........))...(((((........)))))]]((((((((...(((....))).........(((((((......((((((((......{...))))))))((((((((...((.....))......))))))))....)))))))(...)........)))))).)).))).)))....((......)).)))).(((......)))..))))..(.......(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((..)))))).))(..).......(((((((((.].((.........))...(((((((........))))))).}.(((.(((..(((((((.((.............)).)))))..)))))(((((........)))))........((..........((((((.....))))))..)..)....)))....)).))))))).)..))).)))))))...)))))....)).{..((((((.....]}.))))))......(((..(((.((......((((.((((((..(((((.((((((((.((((((((((())))))))))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...((..(((((......)))))..)).(((....))).))]]].].....(((((.(((.]]]]].))))))))....).....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.(((((...(((((((((......))))))..)))..((.(.....).)).......))))..)...))).).....(((((((....))).))))..>.))..))).)))...((((((((((((..((((.((.....(....)....)).)))).(((((...((((...((((((((((}...))))).)))))...)))).)))))..((....((((..............))))....))..))))))))))))......(((.......)).)...((((((((((....(((((..(((....)))..)))))...)))).)))))) Evolutionary compaction and adaptation visualized by the structure of the dormant microsporidian ribosome; 23S rRNA 6rr7 E 11 3.01 URS000197CF7D_384505 31485076 384505 gccugcuuuug ........... ........... Influenza A virus (A/NT/60/1968) polymerase Heterotrimer bound to 3'5' vRNA promoter and capped RNA primer; RNA (5'-R(P*GP*CP*CP*UP*GP*CP*UP*UP*UP*UP*G)-3') 6rr7 D 14 3.01 URS000197CF81_384505 31485076 384505 aguagaaacaaggc .<<....>>..... .((....))..... Influenza A virus (A/NT/60/1968) polymerase Heterotrimer bound to 3'5' vRNA promoter and capped RNA primer; RNA (5'-R(P*AP*GP*UP*AP*GP*AP*AP*AP*CP*AP*AP*GP*GP*C)-3') 6rxt C1 1152 7.0 RF01960,RF01959,RF00177 URS0000EEAD07_209285 31378463 0003735 0005840 209285 ggggggauguccgggucgcccugggcaccucucccggcagccuucgcgggcagccguagucccgguucauacgucgccgcaaucgcgaggggaccaacggguaaccguuccuccaagcggucgccggcgagcaccaccccagccccgcgccgcccccagcgcaccgcgcgcaggggggccggcgcggcaucugggaagacuccuaaggcgcaagggaauaccccgugcgccggggguugggcucugugggugcuuggccgcuggccagaccuacuucaaagccaccggggguaccuaccgguuggggaagcccuagcggcugaaccucucggucgggccuccucuuggggcgccuaggcggugucuucgggucgcgugcagccucccguccucgccugccgacagcgcucuggggaauucaggaggggaaagcagaugugccccgcggcgagacuggcgcaccgccggacgagcugcuggggcacgcggguacgcuagccgcacgauaguuaccugguugauucugcuagucauaugcuugucucaaauacccaaucccgacacggggagguagugacaauaaauacugauacagggcucuuucgggucuuguaauuggaaugaguacaauuuaaaucccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauugcucguaguugaaccugauuaauagggacagucgggggcgucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacaacugcgaaagcauucgccaaggauguuuucauuaaucaggaacguaaacuauuagggaucggacggcguuuauuuuugacccguucggcaccuuacgauaggaguauggucgcaaggcugaaaaauugacggaagggcaccaccagggguggagccugcgcgcgcgcuacacugacagagccagcgaguacucccuuggccgagaggcccggguaaacucugucgugcugaggaaucccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuacuaccgauagaggaaguaggucuccguaggugaaccugcggag <<<<<<.<.<<<<<<....>>>>>>.>.>>>>>><<<<.<<<<....>>>>.>>>>.................<<<<<<<.<<<<<..<<<<...<<<<<....>>>>>.>>>>..>>>>>.>>.>>>>>.......<<<<<..<<<<<<<<<<<<<.<<<<.....>>>>..>>>>>.>>>>>>>>...>>>>>...........<<<<<<.<<<.....>>>.>>>>>>.........................<<<...>>>.....................<<<<<..<<<<<<<<..<<...<<<<.....>>>>...>>..>>>>>.>>>>>>>>.....<<<<<<...<<<<<<<....<<<<..<<.....>>..>>>>....>>>>.>>>....>>>>>>...........................<<<<.<<<<<<<..<.<<<<<.....>>>>>.>..>>>>>..>>>>>><<<<.<.....>.>>>>...........................<<.<<<<<<...<.<<..<.<<<...<<<<.....>>>.>>>>..>>...>.>....<<<<<<<<<<<<<<....>>>>>>>>>.>>>>>.....<<..<...........>..>>.........<<<<<<.......<<<....>>>..................>>>>>>..>>>>>>>>.<.<<...<<<.<<.....>>....<<<<<<.<<...<<<<..<<<.<<<<<<.<...<<<......>>>......>.>>>>>>.>>>.......<<....>>...>>>>..>>.>>>.>>>...>>>...>>.>...........<<..<<<<<<<<.<<<.......>>>>>>>>>>>..>>...................................<<<<<<<<<<<<..<<.<<<<<<..<<<.<<<..>>>.>>>.....<<<<<<<..............<<.<<<<....>>>>.>>.....>>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>............>>>>>..<<<<.<<......>>.>>>>...<<<<<<<<<....>>>>>>>>> ((((.(.(((((.((....)).))))).).))))((((.((((....)))).)))).................(((((((.(((((..((((...(((((....))))).))))..))))).)).)))))..(.(..(((((..(((((((((((((.((((.....))))..))))).))))))))...)))))..)..).....((((((.(((.....))).)))))).........................((([..)))....]................(((((..((((((((..((...(((((..).))))...))..))))).)))))))).....((((((...(((((((....((((..((.....))..))))....)))).)))....))))))...........................(((.((((((((..(.(((((.....))))).)..))))).).)))))((((.(.....).))))..........................(((.((((((...(.(...(.(((...((((.....))).))))..)....).)....((((((((((((((....))))))))).)))))...(.(((.(...........)).))......)..(((((((......(((....)))...............)..))))))..)))))))))(.((...(((.((.....))...(((((((.((...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)).))).)))..))))...)).)..........((.(.((((((((.(((.......)))))))))))..)))..................................(((((.((((((..((.((((((..(((..((()))..))).(...(((((((..............((.((((....)))).)).....))))))).......)..))))))....((((((((.......))))))))......))...)))))).............)))))..((((.((..()..)).))))...(((((.(((....))).))))) Cryo-EM structure of the 90S pre-ribosome (Kre33-Noc4) from Chaetomium thermophilum, state A; 35S ribosomal RNA 6rxt C2 230 7.0 RF01846,RF01848 URS0000EEACFC_209285 31378463 0006396 0005730 209285 agcgacaauacuucagagaaucauuucuauaguaguuguccucucuuguguuuccuaaaggagccacagaucccacccggguugaugaacgagauccucggcgccagugagguccauuuacucucgcucuaccugcaaagguggcggucgcgugccucgucucgcggcuguauagagaguggcgaugaucuguaccccgcggggugggugucgauggaagucugaccggc ............................................................................<<<<......<.......<<<<<<<<<<.<<............<<<<<<...<<<<<<....>>>>>><<<<<<<<.<......>.>>>>>>>>....>>>>>>.........>>.<<<<<<..>>>>>>.>>>>>>>.>>>...>...>>>>. ............................................................................((((......(.......((((((.((((((...(.........(((((...(.((((....)))).)(.((((((.(......).)))))).)....)))))...)......))..(((((()))))).)))).))).)))...)...)))). Cryo-EM structure of the 90S pre-ribosome (Kre33-Noc4) from Chaetomium thermophilum, state A; U3 snoRNA 6rxu C1 1575 3.5 RF01960,RF01959,RF00177 URS0000EEAD07_209285 31378463 0003735 0005840 209285 ggggggauguccgggucgcccugggcaccucucccggcagccuucgcgggcagccguagucccgguucauacgucgccgcaaucgcgaggggaccaacggguaaccguuccuccaagcggucgccggcgagcaccaccccagccccgcgccgcccccagcgcaccgcgcgcaggggggccggcgcggcaucugggaagacuccuaaggcgcaagggaauaccccgugcgccggggguugggcucugugggugcuuggccgcuggccagaccuacuucaaagccaccggggguaccuaccgguuggggaagcccuagcggcugaaccucucggucgggccuccucuuggggcgccuaggcggugucuucgggucgcgugcagccucccguccucgccugccgacagcgcucuggggaauucaggaggggaaagcagaugugccccgcggcgagacuggcgcaccgccggacgagcugcuggggcacgcggguacgcuagccgcacgauaguuaccugguugauucugcuagucauaugcuugucucaaauaagccaugcgucuaaguauaagcaauuauacagcgaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguaccuuacuacauggauaaccgugguaauucuagagcuaauacaugcugaaaaucccgacuucggaagggauguauuuauuagauuaaaaaccaaugcccuucggggcggugauucauaauaacuucucgaaucgcacggccuuggccggcgaugguucauucaaauuucugcccuaucaacuuucgacggcuggguauuggccagccguggugacaacggguaaggguuagggcucggagaaggagccugagaaacggcuacuacauccaaggaagggcaggcgcgcaaauuacccaaucccgacacggggagguagugacaauaaauacugauacagggcucuuucgggucuuguaauuggaaugaguacaauuuaaaucccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauugcucguaguugaaccugggccuagcccgccgguccgccucaccgcgugcacuggcugggcugggccugauuaauagggacagucgggggcgucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacaacugcgaaagcauucgccaaggauguuuucauuaaucaggaacguaaacuauuagggaucggacggcguuuauuuuugacccguucggcaccuuacgauaggaguauggucgcaaggcugaaaaauugacggaagggcaccaccagggguggagccugcgcgcgcgcuacacugacagagccagcgaguacucccuuggccgagaggcccggguaaacucugucgugcugaggaaucccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuacuaccgauagaggaaguaggucuccguaggugaaccugcggag <<<<<<.<.<<<<<<....>>>>>>.>.>>>>>><<<<.<<<<....>>>>.>>>>.................<<<<<<<.<<<<<..<<<<...<<<<<....>>>>>.>>>>..>>>>>.>>.>>>>>.......<<<<<..<<<<<<<<<<<<<.<<<<.....>>>>..>>>>>.>>>>>>>>...>>>>>...........<<<<<<.<<<.....>>>.>>>>>>.........................<<<...>>>.....................<<<<<..<<<<<<<<..<<...<<<<.....>>>>...>>..>>>>>.>>>>>>>>.....<<<<<<...<<<<<<<....<<<<..<<.....>>..>>>>....>>>>.>>>....>>>>>>...........................<<<<.<<<<<<<..<.<<<<<.....>>>>>.>..>>>>>..>>>>>><<<<.<.....>.>>>>...........................<<.<<<<<<...<.<<......<<<.<<<<<....<<....<<.........>>...>>.>>......<<<.......<<<..<<..<<....<<<...............<<..<..<..<<.......>>..>.....>>>........<<<<<..........>>>>><...<<<<<<..............<<<<<..>>>>>.........>>>>>>.....>...<<<<.<<<<....>>>>>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<<....>>>>.>>>.<<.<<<<........>>>>.>>.<.<<<..>>>.>.>>>>>>.........<<<...<<<<.....>>>.>>>>...>...>.>....<<<<<<<<<<<<<<....>>>>>>>>>.>>>>>.....<<..<...........>..>>.........<<<<<<.......<<<....>>>..................>>>>>>..>>>>>>>>.<.<<...<<<.<<...<<<<<<<<<<<<<<<<<.<<<......>>>...>>>>>>.>>>>>>>>>>>..>>....<<<<<<.<<...<<<<..<<<.<<<<<<.<...<<<......>>>......>.>>>>>>.>>>.......<<....>>...>>>>..>>.>>>.>>>...>>>...>>.>...........<<..<<<<<<<<.<<<.......>>>>>>>>>>>..>>...................................<<<<<<<<<<<<..<<.<<<<<<..<<<.<<<..>>>.>>>.....<<<<<<<..............<<.<<<<....>>>>.>>.....>>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>............>>>>>..<<<<.<<......>>.>>>>...<<<<<<<<<....>>>>>>>>> ((((.(.(((((.((....)).))))).).))))((((.((((....)))).)))).................(((((((.(((((..((((...(((((....))))).))))..))))).)).)))))..(.(..(((((..(((((((((((((.((((.....))))..))))).))))))))...)))))..)..).....((((((.(((.....))).)))))).........................((([..)))....]................(((((..((((((((..((...(((((..).))))...))..))))).)))))))).....((((((...(((((((....((((..((.....))..))))....)))).)))....))))))...........................(((.((((((((..(.(((((.....))))).)..))))).).)))))((((.(.....).))))..........................(((.((((((...(.(...(...(((.(((((....((....((.........))...))[))......(((.......(((..((..((....(((...............((.....(..(((.....)))..)......))........(((((..(....)..)))))(.(.((((((..............((((....))))(......).)))))).)...).(.((((..((((..)))).)))))...)))...))))..))).(((....((.....((((((((.......)))))))).))......)))...(.((....)).).))).((.((((........)))).)).(.((....)).).)))))).......(.(((...((((.]...))).))))).)....).)....((((((((((((((....))))))))).)))))...(.(((.(...........)).))......)..(((((((......(((....)))...............)..))))))..)))))))))(.((...(((.((...(((((((((((((((((.(((......)))...)))))).)))))))))))..))...(((((((.((...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)).))).)))..))))...)).)..........((.(.((((((((.(((.......)))))))))))..)))..................................(((((.((((((..((.((((((..(((..((()))..))).(...(((((((..............((.((((....)))).)).....))))))).......)..))))))....((((((((.......))))))))......))...)))))).............)))))..((((.((..()..)).))))...(((((.(((....))).))))) Cryo-EM structure of the 90S pre-ribosome (Kre33-Noc4) from Chaetomium thermophilum, state B1; 35S rRNA 6rxu C2 230 3.5 RF01846,RF01848 URS0000EEACFC_209285 31378463 0006396 0005730 209285 agcgacaauacuucagagaaucauuucuauaguaguuguccucucuuguguuuccuaaaggagccacagaucccacccggguugaugaacgagauccucggcgccagugagguccauuuacucucgcucuaccugcaaagguggcggucgcgugccucgucucgcggcuguauagagaguggcgaugaucuguaccccgcggggugggugucgauggaagucugaccggc ............................................................................<<<<......<.......<<<<<<<<<<.<<............<<<<<<...<<<<<<....>>>>>><<<<<<<<.<......>.>>>>>>>>....>>>>>>.........>>.<<<<<<..>>>>>>.>>>>>>>.>>>...>...>>>>. ............................................................................((((......(.......((((((.((((((...(.........(((((...(.((((....)))).)(.((((((.(......).)))))).)....)))))...)......))..(((((()))))).)))).))).)))...)...)))). Cryo-EM structure of the 90S pre-ribosome (Kre33-Noc4) from Chaetomium thermophilum, state B1; U3 snoRNA 6rxv C1 1575 4.0 RF01960,RF01959,RF00177 URS0000EEAD07_759272 31378463 0003735 0005840 759272 ggggggauguccgggucgcccugggcaccucucccggcagccuucgcgggcagccguagucccgguucauacgucgccgcaaucgcgaggggaccaacggguaaccguuccuccaagcggucgccggcgagcaccaccccagccccgcgccgcccccagcgcaccgcgcgcaggggggccggcgcggcaucugggaagacuccuaaggcgcaagggaauaccccgugcgccggggguugggcucugugggugcuuggccgcuggccagaccuacuucaaagccaccggggguaccuaccgguuggggaagcccuagcggcugaaccucucggucgggccuccucuuggggcgccuaggcggugucuucgggucgcgugcagccucccguccucgccugccgacagcgcucuggggaauucaggaggggaaagcagaugugccccgcggcgagacuggcgcaccgccggacgagcugcuggggcacgcggguacgcuagccgcacgauaguuaccugguugauucugcuagucauaugcuugucucaaauaagccaugcgucuaaguauaagcaauuauacagcgaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguaccuuacuacauggauaaccgugguaauucuagagcuaauacaugcugaaaaucccgacuucggaagggauguauuuauuagauuaaaaaccaaugcccuucggggcggugauucauaauaacuucucgaaucgcacggccuuggccggcgaugguucauucaaauuucugcccuaucaacuuucgacggcuggguauuggccagccguggugacaacggguaaggguuagggcucggagaaggagccugagaaacggcuacuacauccaaggaagggcaggcgcgcaaauuacccaaucccgacacggggagguagugacaauaaauacugauacagggcucuuucgggucuuguaauuggaaugaguacaauuuaaaucccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauugcucguaguugaaccugggccuagcccgccgguccgccucaccgcgugcacuggcugggcugggccugauuaauagggacagucgggggcgucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacaacugcgaaagcauucgccaaggauguuuucauuaaucaggaacguaaacuauuagggaucggacggcguuuauuuuugacccguucggcaccuuacgauaggaguauggucgcaaggcugaaaaauugacggaagggcaccaccagggguggagccugcgcgcgcgcuacacugacagagccagcgaguacucccuuggccgagaggcccggguaaacucugucgugcugaggaaucccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuacuaccgauagaggaaguaggucuccguaggugaaccugcggag <<<<<<.<<<<<<<<....>>>>>>>>.>>>>>><<<<.<<<<....>>>>.>>>>.................<<<<<<<.<<<<<..<<<<...<<<<<....>>>>>.>>>>..>>>>>.>>.>>>>>.......<<<<<..<<<<<<<<<<<<<.<<<<.....>>>>..>>>>>.>>>>>>>>...>>>>>...........<<<<<<.<<<.....>>>.>>>>>>.........................<<<...>>>.....................<<<<<..<<<<<<<<..<<...<<<<.....>>>>...>>..>>>>>.>>>>>>>>.....<<<<<<...<<<<<<<....<<<<..<<.....>>..>>>>....>>>>.>>>....>>>>>>...........................<<<<<<<<<<<<..<.<<<<<.....>>>>>.>..>>>>>.>>>>>>><<<<.........>>>>...........................<<.<<<<<<...<.<<......<<<.<<<<<....<<....<<.........>>...>>.>>......<<<.......<<<..<<..<<....<<<...............<<.....<..<<.......>>..>......>>........<<<<<..........>>>>><...<<<<<<..............<<<<....>>>>.........>>>>>>.....>...<<<<.<<<<....>>>>>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<<....>>>>.>>>.<<.<<<<........>>>>.>>.<.<<<..>>>.>.>>>>>>.........<<<...<<<<.....>>>.>>>>...>...>.>....<<<<<<<<<<<<<<....>>>>>>>>>.>>>>>.....<<..<...........>..>>.........<<<<<<.......<<<....>>>..................>>>>>>..>>>>>>>>.<.<<...<<<.<<...<<<<<<<<<<<<<<<<<.<<<......>>>...>>>>>>.>>>>>>>>>>>..>>....<<<<<<.<<...<<<<..<<<.<<<<<<.<...<<<......>>>......>.>>>>>>.>>>.......<<....>>...>>>>..>>.>>>.>>>...>>>...>>.>...........<<..<<<<<<<<.<<<.......>>>>>>>>>>>..>>...................................<<<<<<<<<<<<..<<.<<<<<<..<<<.<<<..>>>.>>>.....<<<<<<<..............<<.<<<<....>>>>.>>.....>>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>............>>>>>..<<<<.<<......>>.>>>>...<<<<<<<<<....>>>>>>>>> ((((.(.(((((.((....)).))))).).))))((((.((((....)))).)))).................(((((((.(((((..((((...(((((....))))).))))..))))).)).)))))..(.(..(((((..(((((((((((((.((((.....))))..))))).))))))))...)))))..)..).....((((((.(((.....))).)))))).........................((([..)))....]................(((((..((((((((..((...(((((..).))))...))..))))).)))))))).....((((((...(((((((....((((..((.....))..))))....)))).)))....))))))...........................((((.(((((((..(.(((((.....))))).)..))))).).)))))((((.(.....).))))..........................(((.((((((...(.(...(...(((.(((((....((....((.........))...))[))......(((.......(((..((..((....(((...............((.....(..(((.....)))..)......))........(((((..(....)..)))))(.(.((((((..............((((....))))(......).)))))).)...).(.((((..((((..)))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...((((....)))).))).((.((((........)))).)).(.((....)).).)))))).......(.(((...((((.]...))).))))).)....).)....((((((((((((((....))))))))).)))))...(.(((.(...........)).))......)..(((((((......(((....)))...............)..))))))..)))))))))(.((...(((.((...(((((((((((((((((.(((......)))...)))))).)))))))))))..))...(((((((.((...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)).))).)))..))))...)).)..........(((..((((((((.(((.......)))))))))))..)))..................................(((((.((((((..((.((((((..(((..((()))..))).(...(((((((..............((.((((....)))).)).....))))))).......)..))))))....((((((((.......))))))))......))...)))))).............)))))..((((.((..()..)).))))...(((((.(((....))).))))) Cryo-EM structure of the 90S pre-ribosome (Kre33-Noc4) from Chaetomium thermophilum, state B2; 35S ribosomal RNA 6rxv C2 230 4.0 RF01846,RF01848 URS0000EEACFC_759272 31378463 0006396 0005730 759272 agcgacaauacuucagagaaucauuucuauaguaguuguccucucuuguguuuccuaaaggagccacagaucccacccggguugaugaacgagauccucggcgccagugagguccauuuacucucgcucuaccugcaaagguggcggucgcgugccucgucucgcggcuguauagagaguggcgaugaucuguaccccgcggggugggugucgauggaagucugaccggc ............................................................................<<<<......<.......<<<<<<<<<<.<<............<<<<<<...<<<<<<....>>>>>><<<<<<<<.<......>.>>>>>>>>....>>>>>>.........>>.<<<<<<..>>>>>>.>>>>>>>.>>>...>...>>>>. ............................................................................((((......(.......((((((.((((((...(.........(((((...(.((((....)))).)(.((((((.(......).)))))).)....)))))...)......)).(..(((())))..))))).))).)))...)...)))). Cryo-EM structure of the 90S pre-ribosome (Kre33-Noc4) from Chaetomium thermophilum, state B2; U3 snoRNA 6rxx C1 1221 7.1 RF01960,RF01959,RF00177 URS0000EEAD0E_209285 31378463 0003735 0005840 209285 ggggggauguccgggucgcccugggcaccucucccggcagccuucgcgggcagccguagucccgguucauacgggcucugugggugggggaauucaggaggggaaaacgauaguuaccugguugauucugcuagucauaugcuugucucaaauaagccaugcgucuaaguauaagcaauuauacagcgaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguaccuuacuacauggauaaccgugguaauucuagagcuaauacaugcugaaaaucccgacuucggaagggauguauuuauuagauuaaaaaccaaugcccuucggggcggugauucauaauaacuucucgaaucgcacggccuuggccggcgaugguucauucaaauuucugcccuaucaacuuucgacggcuggguauuggccagccguggugacaacggguaaggguuagggcucggagaaggagccugagaaacggcuacuacauccaaggaagggcaggcgcgcaaauuacccaaucccgacacggggagguagugacaauaaauacugauacagggcucuuucgggucuuguaauuggaaugaguacaauuuaaaucccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauugcucguaguugaaccugggccuagcccgccgguccgccucaccgcgugcacuggcugggcugggccugauuaauagggacagucgggggcgucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacaacugcgaaagcauucgccaaggauguuuucauuaaucaggaacguaaacuauuagggaucggacggcguuuauuuuugacccguucggcaccuuacgauaggaguauggucgcaaggcugaaaaauugacggaagggcaccaccagggguggagccugcgcgcgcgcuacacugacagagccagcgaguacucccuuggccgagaggcccggguaaucuuguuaaacucugucgugcuggggauagagcauugcaauuauugcucuucaacgaggaaucccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuacuaccgauagaggaaguaggucuccguaggugaaccugcggag <<<<<<.<.<<<<<<....>>>>>>.>.>>>>>><<<<.<<<<....>>>>.>>>>.............................................................................<<.<<<<<<...<.<<......<<<.<<<<<....<<....<<.........>>...>>.>>......<<<.......<<<..<<..<<....<<<...............<<..<..<..<<.......>>..>.....>>>........<<<<<..........>>>>><...<<<<<<..............<<<<<..>>>>>.........>>>>>>.....>...<<<<.<<<<....>>>>>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<<....>>>>.>>>.<<.<<<<........>>>>.>>.<.<<<..>>>.>.>>>>>>.........<<<...<<<<.....>>>.>>>>...>...>.>....<<<<<<<<<<<<<<....>>>>>>>>>.>>>>>.....<<..<...........>..>>.........<<<<<<.......<<<....>>>..................>>>>>>..>>>>>>>>.<.<<...<<<.<<...<<<<<<<<<<<<<<<<<.<<<......>>>...>>>>>>.>>>>>>>>>>>..>>....<<<<<<.<<...<<<<..<<<.<<<<<<.<...<<<......>>>......>.>>>>>>.>>>.......<<....>>...>>>>..>>.>>>.>>>...>>>...>>.>...........<<..<<<<<<<<.<<<.......>>>>>>>>>>>..>>...................................<<<<<<<<<<<<..<<.<<<<<<..<<<..........>>>.....<<<<<<<......<<.....<<<.<<<<....>>>>.>>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>............>>>>>..<<<<.<<......>>.>>>>...<<<<<<<<<....>>>>>>>>> ((((.(.(((((.((....)).))))).).))))((((.((((....)))).))))............................................................................(((.((((((...(.(...(...(((.(((((....((....((.........))...))[))......(((.......(((..((..((....(((...............((.....(..(((.....)))..)......))........(((((..(....)..)))))(.(.((((((..............((((....))))(......).)))))).)...).(.((((..((((..)))).)))))...)))...))))..))).(((....((.....((((((((.......)))))))).))......)))...(.((....)).).))).((.((((........)))).)).(.((....)).).)))))).......(.(((...((((.]...))).))))).)....).)....((((((((((((((....))))))))).)))))...(.(((.(...........)).))......)..(((((((......(((....)))...............)..))))))..)))))))))(.((...(((.((...(((((((((((((((((.(((......)))...)))))).)))))))))))..))...(((((((.((...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)).))).)))..))))...)).)..........((.(.((((((((.(((.......)))))))))))..)))..................................(((((.((((((..((.((((((...................(...(((((((......((.....(((.((((....)))).)))....)).......)))))))......(....((((((..........))))))....)..)..))))))....((((((((.......))))))))......))...)))))).............)))))..((((.((..()..)).))))...(((((.(((....))).))))) Cryo-EM structure of the 90S pre-ribosome (Kre33-Noc4) from Chaetomium thermophilum, state C, Poly-Ala; 35S ribosomal RNA 6rxx C2 229 7.1 RF01846,RF01848 URS0000EEAD02_209285 31378463 0006396 0005730 209285 agcgacaauacuucagagaaucauuucuauaguaguuguccucucuuguguuuccuaaaggagccacagaucccacccggguugaugaacgagauccucggcgccagugagguccuuuacucucgcucuaccugcaaagguggcggucgcgugccucgucucgcggcuguauagagaguggcgaugaucuguaccccgcggggugggugucgauggaagucugaccggc ............................................................................<<<<......<.......<<<<<<<<<<.<<...........<<<<<<...<<<<<<....>>>>>><<<<<<<<.<......>.>>>>>>>>....>>>>>>.........>>.<<<<<<..>>>>>>.>>>>>>>.>>>...>...>>>>. ............................................................................((((......(.......((((((.((((((...(........(((((...(.((((....)))).)(.((((((.(......).)))))).)....)))))...)......))..(((((()))))).)))).))).)))...)...)))). Cryo-EM structure of the 90S pre-ribosome (Kre33-Noc4) from Chaetomium thermophilum, state C, Poly-Ala; U3 snoRNA 6rxy C1 1106 4.7 RF01960,RF01959,RF00177 URS0000EEACFD_209285 31378463 0003735 0005840 209285 ggggggauguccgggucgcccugggcaccucucccggcagccuucgcgggcagccguagucccgguucauacgucgccgcaaucgcgaggggaccaacggguaaccguuccuccaagcggucgccggcgagcaccaccccagccccgcgccgcccccagcgcaccgcgcgcaggggggccggcgcggcaucugggaagacuccuaaggcgcaagggaauaccccgugcgccggggguugggcucugugggugcuuggccgcuggccagaccuacuucaaagccaccggggguaccuaccgguugucucggucgggccuccucuuggggcgccuaggcggugucuucgggucgcgugcagccucccguccucgccugccgacagcgcucuggggaauucaggaggggaaagcagaugugccccgcggcgagacuggcgcaccgccggacgagcugcuggggcacgcggguacgcuagccgcacgauaguuaccugguugauucugcuagucauaugcuugucucaaaugacaauaaauacugauacagggcucuuucgggucuuguaauuggaaugaguacaauuuaaaucccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauugcucguaguugaaccugauuaauagggacagucgggggcgucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacaacugcgaaagcauucgccaaggauguuuucauuaaucaggaacgauuagggaucggacggcguuuauuuuugacccguucggcaccuuacgauaaaucaaaaggaguauggucgcaaggcugaaaaauugacggaagggcaccaccagggguggagccugcgcgcgcgcuacacugacagagccagcgaguacucccuuggccgagaggcccggguaaacucugucgugcugaggaaucccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuacuaccgauagaggaaguaggucuccguaggugaaccugcggag <<<<<<.<..<<<<<....>>>>>..>.>>>>>><<<<.<<<<....>>>>.>>>>.................<<<<<<<.<<<<<..<<<<...<<<<<....>>>>>.>>>>..>>>>>.>>.>>>>>....<..<<<<<..<<<<<<<<<<<<<.<<<<.....>>>>..>>>>>.>>>>>>>>...>>>>>..>........<<<<<<.<<<.....>>>.>>>>>>.........................<<<...>>>.....................<<<<<..<<<<<<<<.....>>>>>.>>>>>>>>.....<<<<<<...<<<<<<<....<<<<..<<.....>>..>>>>....>>>>.>>>....>>>>>>...........................<<<<<<<<<<<<..<.<<<<<.....>>>>>.>..>>>>>.>>>>>>><<<<.........>>>>...........................<<.<<<<<<...<.<<....>...>.>....<<<<<<<<<<<<<<....>>>>>>>>>.>>>>>.....<<..<...........>..>>.........<<<<<<.......<<<....>>>..................>>>>>>..>>>>>>>>.<.<<...<<<.<<.....>>....<<<<<<.<<...<<<<..<<<.<<<<<<.....<<<......>>>........>>>>>>.>>>.......<<....>>...>>>>..>>.>>>.>>>...>>>...>>.>.....<<..<<<<<<<<.<<<.......>>>>>>>>>>>..>>.....<....>................................<<<<<<<<<<<<..<<.<<<<<<..<<<.<<<..>>>.>>>.....<<<<<<<..............<<.<<<<....>>>>.>>.....>>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>............>>>>>..<<<<.<<......>>.>>>>...<<<<<<<<<....>>>>>>>>> ((((.(.(((((.((....)).))))).).))))((((.((((....)))).)))).................(((((((.(((((..((((...(((((....))))).))))..))))).)).)))))..(.(..(((((..((((((((((.((.((((.....))))..).))).))))))))...)))))..)..).....((((((.(((.....))).)))))).........................((([..)))....]................(((((..(((((((.......)))).)))))))).....((((((...(((((.(....((((..((.....))..))))....).)).)))....))))))...........................((((.(((((((..(.(((((.....))))).)..))))).).)))))((((.(.....).))))..........................(((.((((((...(.(...()....).)....((((((((((((((....))))))))).)))))...(.(((.(...........)).))......)..(((((((......(((....)))...............)..))))))..)))))))))(.((...(((.((.....))...((.((((.((...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)).))).).)..))))...)).)..(..(((..(((((((.(((.......))))))))))...)))...((....))...)...........................(((((.((((((..((..(((((..(((..((()))..))).(...(((((((..............((.((((....)))).)).....))))))).......)..))))).....(.((((((.......)))))).)......))...)))))).............)))))..((((.((..()..)).))))...(((((.(((....))).))))) Cryo-EM structure of the 90S pre-ribosome (Kre33-Noc4) from Chaetomium thermophilum, state a; 35S rRNA 6rxy C2 230 4.7 RF01846,RF01848 URS0000EEACFC_209285 31378463 0006396 0005730 209285 agcgacaauacuucagagaaucauuucuauaguaguuguccucucuuguguuuccuaaaggagccacagaucccacccggguugaugaacgagauccucggcgccagugagguccauuuacucucgcucuaccugcaaagguggcggucgcgugccucgucucgcggcuguauagagaguggcgaugaucuguaccccgcggggugggugucgauggaagucugaccggc ............................................................................<<<<..............<<<<<<<<<<.<<............<<<<<<...<<<<<......>>>>><<<<<<<<.<......>.>>>>>>>>....>>>>>>.........>>.<<<<<<..>>>>>>.>>>>>>>.>>>.......>>>>. ............................................................................((((......(.......((((((.((((((...(.........(((((...(.((((....)))).)(.((((((.(......).)))))).)....)))))...)......))....(((())))...)))).))).)))...)...)))). Cryo-EM structure of the 90S pre-ribosome (Kre33-Noc4) from Chaetomium thermophilum, state a; U3 snoRNA 6rxz C1 1487 4.4 RF01960,RF01959,RF00177 URS0000EEACFD_209285 31378463 0003735 0005840 209285 ggggggauguccgggucgcccugggcaccucucccggcagccuucgcgggcagccguagucccgguucauacgucgccgcaaucgcgaggggaccaacggguaaccguuccuccaagcggucgccggcgagcaccaccccagccccgcgccgcccccagcgcaccgcgcgcaggggggccggcgcggcaucugggaagacuccuaaggcgcaagggaauaccccgugcgccggggguugggcucugugggugcuuggccgcuggccagaccuacuucaaagccaccggggguaccuaccgguugucucggucgggccuccucuuggggcgccuaggcggugucuucgggucgcgugcagccucccguccucgccugccgacagcgcucuggggaauucaggaggggaaagcagaugugccccgcggcgagacuggcgcaccgccggacgagcugcuggggcacgcggguacgcuagccgcacgauaguuaccugguugauucugcuagucauaugcuugucucaaauaagccaugcgucuaaguauaagcaauuacagcgaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguaccuuacuauggauaaccgugguaauucuagagcuaauacaugcaaaaucccgacuucggaagggauguauuuauuagagcccuucggggcggugauucauaauaacuucucgaaucgcacggccuugcgccggcgaugguucauucaaauuucugcccuaucaacuuucgacggcuggguauuggccagccguggugacaacggguaaggguuagggcucggagaaggagccugagaaacggcuacuacauccaaggaagggcaggcgcgcaaauuacccaaucccgacacggggagguagugacaauaaauacugauacagggcucuuucgggucuuguaauuggaaugaguacaauuuaaaucccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauugcucguaguugaaccugauuaauagggacagucgggggcgucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacaacugcgaaagcauucgccaaggauguuuucauuaaucaggaacgauuagggaucggacggcguuuauuuuugacccguucggcaccuuacgauaaaucaaaaggaguauggucgcaaggcugaaaaauugacggaagggcaccaccagggguggagccugcgcgcgcgcuacacugacagagccagcgaguacucccuuggccgagaggcccggguaaacucugucgugcugaggaaucccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuacuaccgauagaggaaguaggucuccguaggugaaccugcggag <<<<<<.<<.<<<<<....>>>>>.>>.>>>>>><<<<.<<<<....>>>>.>>>>.................<<<<<<<.<<<<<..<<<<...<<<<<....>>>>>.>>>>..>>>>>.>>.>>>>>.......<<<<<..<<<<<<<<<<<<<.<<<<.....>>>>..>>>>>.>>>>>>>>...>>>>>...........<<<<<<.<<<.....>>>.>>>>>>.........................<<<...>>>.....................<<<<<..<<<<<<<<.....>>>>>.>>>>>>>>.....<<<<<<...<<<<<<<....<<<<..<<.....>>..>>>>....>>>>.>>>....>>>>>>...........................<<<<<<<<<<<<..<.<<<<<.....>>>>>.>..>>>>>.>>>>>>><<<<.........>>>>...........................<<.<<<<<<...<.<<..<...<<<.<<<<<....<<....<<.......>>...>>.>>......<<<.......<<<..<<..<<....<<<.............<<..<..<..<<<.....>>>..>.....>>>......<<<<<..........>>>>><...<<<<<<..<<<<....>>>>.........>>>>>>.....>...<<<<.<<<<.....>>>>>>>>....>>>...>>>>..>>>.<<<....<<.....<<<<<<<<.......>>>>>>>>.>>......>>>...<<<......>>>.>>>.<<.<<<<........>>>>.>>.<.<<<..>>>.>.>>>>>>.........<<<....<<<<...>>>>..>>>..>>...>.>....<<<<<<<<<<<<<<....>>>>>>>>>.>>>>>.....<<..<...........>..>>.........<<<<<<.......<<<....>>>..................>>>>>>..>>>>>>>>.<.<<...<<<.<<.....>>....<<.<<<.<<...<<<<..<<<.<<<<<<.....<<<......>>>........>>>>>>.>>>.......<<....>>...>>>>..>>.>>>..>>...>>>...>>.>.....<<..<<<<<<<<.<<<.......>>>>>>>>>>>..>>.....<....>................................<<<<<<<<<<<<..<<.<<<<<<..<<<.<<<..>>>.>>>.....<<<<<<<..............<<.<<<<....>>>>.>>.....>>>>>>>..........>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>............>>>>>..<<<<.<<......>>.>>>>...<<<<<<<<<....>>>>>>>>> ((((.(.(((((.((....)).))))).).))))((((.((((....)))).)))).................(((((((.(((((..((((...(((((....))))).))))..))))).)).)))))..(.(..(((((..((((((((((.((.((((.....))))..).))).))))))))...)))))..)..).....((((((.(((.....))).)))))).........................((([..)))....]................(((((..(((((((.......)))).)))))))).....((((((...(((((((....((((..((.....))..))))....)))).)))....))))))...........................((((.(((((((..(.(.(((.....))).).)..))))).).)))))((((.(.....).))))..........................(((.((((((...(.(...(...(((.(((((....((....((.......))...))[))......(((.......(((..((..((....(((.............(.(....(..(((.....)))..)......))......(((((..(....)..)))))(.(.((((((..((((....))))(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).((.....((.....((((((((.......)))))))).)).......))...(.(......).).))).((.((((........)))).)).(.((....)).).)))))).......(.(((...((((.]...))).))))).)....).)....((((((((((((((....))))))))).)))))...(.(((.(...........)).))......)..(((((((......(((....)))...............)..))))))..)))))))))(.((...(((.((.....))...((.((((.((...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)).))).).)..))))...)).)..(...((.((((((((.(((.......)))))))))))..))....((....))...)...........................(((((.((((((..((.((((((..(((..((()))..))).(...(((((((..............((.((((....)))).)).....))))))).......)..))))))....((((((((.......))))))))......))...)))))).............)))))..((((.((..()..)).))))...(((((.(((....))).))))) Cryo-EM structure of the 90S pre-ribosome (Kre33-Noc4) from Chaetomium thermophilum, state b; 35S ribosomal RNA 6rxz C2 230 4.4 RF01846,RF01848 URS0000EEACFC_209285 31378463 0006396 0005730 209285 agcgacaauacuucagagaaucauuucuauaguaguuguccucucuuguguuuccuaaaggagccacagaucccacccggguugaugaacgagauccucggcgccagugagguccauuuacucucgcucuaccugcaaagguggcggucgcgugccucgucucgcggcuguauagagaguggcgaugaucuguaccccgcggggugggugucgauggaagucugaccggc ............................................................................<<<<......<.......<<<<<<<<<<.<<............<<<<<<...<<<<<......>>>>><<<<<<<<.<......>.>>>>>>>>....>>>>>>.........>>.<<<<<<..>>>>>>.>>>>>>>.>>>...>...>>>>. ............................................................................((((......(.......((((((.((((((...(.........(((((...(.((((....)))).)(.((((((.(......).)))))).)....)))))...)......))..(((((()))))).)))).))).)))...)...)))). Cryo-EM structure of the 90S pre-ribosome (Kre33-Noc4) from Chaetomium thermophilum, state b; U3 snoRNA 6rzz A 3146 3.2 RF02540,RF02543 URS000061F377_4932 31115337 0003735 0005840 4932 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucgggucgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauagaggguguagaauaagugggagcuucggcgccagugaaauaccacuaccuuuauaguuucuuuacuuauucaaugaagcggagacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuacgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>...<.....<<....>>..<<<<<......<<.....>>.....>>>>>..<<<..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<.<<<<<...<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>>..>>>>.......>>>>>>>>>>>........<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>....>.............................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<<.....<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<..........>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<...................<<<<<.....>>>>>................>>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>.........<<..............>>.....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<<....<<<....>>>.......<<<<<<...<<<<.<<<<<<<<<<<<<<<<<<..[[[..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<<....>>>>>>>>>>>>.>.>>>>>>>.>>>>.........>>>>>>.........>>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<.<<<<<<<<<<.....>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>.<.<<..<<<..<<<<<<.<..<<<.....<<<<....>>>>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>.>..>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<..<<<<<<<<<<.<<<....................<<....>>.....................>>>..>>>>>>>>>>...<<<<<.....<<<<.................<<<<<......>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))......<<<<<<<..<<<<.))))))>>>>>>>>>>>.........>>>>..>>>>>>....<..<<.<...<<<<<<...<<.......>>...>>>>>>....>..>>.>.....<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<....<<<<<<<<<<]]].>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<.....<<..........<<<<<<.....>>>>>>......>>.......<...>..............>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((.(((.(((((..((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))).).....)))))))).))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((......(((..........))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((((((((((....((.(((((((.....((....................(((((.....)))))................).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.(((((((.((.......(((((..((...((.........))...))..........((......))...)))))...)).))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...((((((...((.....)).))))))....[[(((.((...((....(((....)))..........((.(........).))......))....))...(((((........)))))]]((((..(((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((((.....))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))((((((.......))))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..((((((.(((..(...........[.....(...((....))..........].).........)...))).))))))...(((((.....((((.............>...(((.(......).)))..))))..))))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......(..(.(..(.(.....((.......)).....).)....))...)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.............))))...)))).))))....)))))))).......((((((.(((.(.....((.(........((((((.....)))))).....))).......(...)..............).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(((.((..)..).)))..)))))...)))....)))).)))))).))))).. Cryo-EM structures of Lsg1-TAP pre-60S ribosomal particles; 25S ribosomal RNA 6rzz x 121 3.2 RF00001 URS000055688D_4932 31115337 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<<............>>>....>>....>>>>>>.>><<<<<........<<<<<..<<....>>.>>>>>......>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Cryo-EM structures of Lsg1-TAP pre-60S ribosomal particles; 5S ribosomal RNA 6rzz y 156 3.2 RF00002 URS00001BF64E_4932 31115337 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucau .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))................... Cryo-EM structures of Lsg1-TAP pre-60S ribosomal particles; 5.8S ribosomal RNA 6s05 A 3146 3.9 RF02540,RF02543 URS000061F377_4932 31115337 0003735 0005840 4932 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucgggucgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauagaggguguagaauaagugggagcuucggcgccagugaaauaccacuaccuuuauaguuucuuuacuuauucaaugaagcggagacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuacgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<........<<.<<<<<<...>>>>>>.>>........>....<<<<<<.<<<<<..<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>>..>>>>>......>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<<.....<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<..........>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<...........<........<<<.......>>>......>..........>>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<........<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>....>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><<<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>.>>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>.........<<..............>>.....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<<....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>>....<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>.....<<<<<<<<....>>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>.........>>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<.<<<<<<<<<<<...>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>.<.<<..<<<..<<<<<.....<<<....<<<<<....>>>>.>...>>>..>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>.>..>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<<<<<<..................<.<<....>>............>........>>>>.>>>>>>>>>>...<<<<<.....<<<<.................<<<<<......>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]]....<..<<..<<.<<..<....<<.......>>....>..>>...>>.>.>.>.....<.<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>..>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<...<<<<<<<<<<<}}}.>>>>>..>>>>>>..>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.........................>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(......).......)))).).........((....))...((((......((.....)).....))))...((((.........(((.((((((...)))))).))....).........(((((.(((((...((.((((((((((...(.((.(......).)))[.(...).(((......])))....))))))))..)).)).......))))))))))....)....(((((((........)))))))......((((..[[[[.[))))...)))..................................((....))...............((((....))))..................................(((((.((((((.....((((((((((((((((..(((((.......(((.(((......((............)).......))).))).....)))))...))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....(((((..((((((..(((...(((.......)))...)))...((....)).......((((...(((((....)))))....)))).((((((((....(....)....))).))).))....))))))..)))))...(.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(..(.......)....)..))))))......).)...((((((....(.(((....))).)((((((((((...(((.(((((((.....((....................(((((.....)))))................).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(.((.(....))).).)))).....((......))....(((((((...((([[[...(.((((((......(..........(((.(((((((..........(((((...(...((.........))...)...........((......))...)))))......))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((........((.((((....)))))).....))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((.(..((...((.((....((.....))..)).))....[.(((.((...((....(((....)))...........(.(........).).......))....))...(((((........))))).]((((..(((((((...((((....)))...(.<.((((((...(((.(((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((..(......)..)))))))).).))))))).))))(...)....))))))...))....))))..))).)))).)))..)).....((......)).).)).((((.....))))..))))..((((.....(((((((.((..(....(........((((....(.{..).....)))).((.(((((.(..(.....)..)...))))).))............(((((((((.].((.........))...(((((((....((((.....))))......))))))).}...(.(((..(.((.(.....((....(((((....)))).)...))...)))...))))((((((.......))))))........((..........(((((.......)))))..)..)....)......)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))......(((..(((.((.......((...(((((..((((..((((((((..((.(((..((.((.....................(......)......................))..))..)).)))....((((.....((((.............>...(((((......)))))..))))..))))......))))))))...))))..(((......[)).)((((((..........]))))))([((.....(((((.(.((((((.......))))))...).((][.[[[))....)))))...(.(((..((((....{..))))..))))(((....))).))]]].].....(((((...((((.].]]]])))).)))))....)}....))))..)..))........((.....((..(....((.......)).....).))......).).........(((.((((((..(.(((((..........))))..).).(((.(.....).))).....)))))..)...))).......(((((((....))).))))..>.))..))).)))......((((((....((((.(.(((((.................))))).)(((((...((((....(((.((((((}}..)))))..).)))...))))..))))).((((...((.(.............).))...)))).))))......)))))).......(.(((..(...((....((.(........(((((((..).)))))).....))).......(...).............))...)..))).)..(((((.(..(.......)..)...(.(((((.((..(((....((((.(..(((.(......).)))..)))))...))).....).).)))))).))))).. Cryo-EM structures of Lsg1-TAP pre-60S ribosomal particles; 25S ribosomal RNA 6s05 x 121 3.9 RF00001 URS000055688D_4932 31115337 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<........<<<<..<<....>>.>>>>......>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((............))).)..))....)))))).)).(((((.........(((..((....)).))).......))))).))))))))). Cryo-EM structures of Lsg1-TAP pre-60S ribosomal particles; 5S ribosomal RNA 6s05 y 156 3.9 RF00002 URS00001BF64E_4932 31115337 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucau .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))((.((.(((....))).)).))................... Cryo-EM structures of Lsg1-TAP pre-60S ribosomal particles; 5.8S ribosomal RNA 6s0k A 2883 3.1 RF02540,RF02541 URS00008FED41_562 31570874 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggguuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<..>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<..>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<.>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<..<<....>>...>>>>>..>....>>>>>>>>>..>>>>><<<<<<...>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>...>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))((((((((..)))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......((((.((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))).))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((..))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...............)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((((((.)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.....)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((.(((..(.(...........(.(((...((......(((..(.(....).)..)))...)).............))).)..).)..))).)))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Ribosome nascent chain in complex with SecA; 23S ribosomal RNA 6s0k B 120 3.1 RF00001 URS0000049E57_562 31570874 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Ribosome nascent chain in complex with SecA; 5S ribosomal RNA 6s0x A 2905 2.425 RF02540,RF02541,RF00002 URS0000EEACE5_1280 31391518 0003735 0005840 1280 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.(((((......(.((.(((((.....(((..((((((((....(......((((.(..[..[[)..).....((((((......]]..]...........))))))...)))....(((....)))(((((((......))))))).(((((((.(.........).))))).)).).....(((((......(...[<.).......)))).).........((....))...((((......((.]...)).....))))...((((...((((((((....))))))))........(((((...........................(((...(((((......)))))[[(...).(((.....]])))...)))....................)))..))..)....((((((....[........))))))......(((((].[[[[)))))..)))..........)))))).))...............((....))....)).........((((....)))).............).....))))).)).).......(((...((((..[...))))...))).....(........)...((((.(...(.(((((...((.(..(.....(((.....))).....)...((....))..((((.....)))).....).))...))))))..((.(...((((((.....((((((((((.((((...(((((........)))))...)<)))...(((.(((((........))))))))..).))))))))).(.(((....[)))...).]))))))......).))..((((((....(.(((....))).)(.(((((((....(((((.((.....(.(...(((.((.(...((.........))....))).)))..)..).....)))..))))...)))))))..)....((..((..........))..)).......((......))....((.(.(((....((.[[.....((((((.....(......(..(.((.((..(.....{...((....(...((.........))...).........................).)....)..)).)).).)............]]..)...)))))).))....)))).)).(((((....).)))).....))))))(.(((((((.((.......((((..(....).]))))....)).)))))))..).....)).)))(......(.....((((((.......))))))((((....(((...((...(((..(...(.......).)..)))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((((..(.............(.((....(((((.(((..................{..........(....(((....((.(((((((.((.....)))))))))......))....))).....)...............................)))..)))))(..).....)).).........))))))))))))..)).....((......))..))).(((.......)))..))))...(((..........(..((..(....(.......(((((....(.[..).....)))))(((((...((........))...)))))(...).......(((((((((.>.(...........)...(((((((.....(((....))).......))))))).]((((..((..(((((((..(.....((...(((((.............)))))...))....).)))))..)))).(.(((.....))).).........(..........(((((.......)))))..).......))))...)).))))))).)..))).)........)))..).....)..[..((.((......].)).))..((((((.(.((..(.......((((.((((((..(((((.(((((((((.((((.((((..(.(................((..(.(...........(........)........).)............)).......).)..)))).)))).....(.((((((.....)))))))......)))))))))..)))))...(.......[.).((((((..........]))))))([.(.......(((.(.(((((.........)))))...).((][.[[[))....))).......(((...(.(...{..).)...))).(((....))).).]]].].....((.(((..((..]]]]..)).))).)).....)}..>...))))..))))))......(.((....((((((...((.......))...)))))).....))...).....(((((.((.(((..((((((.((......)).)))..))).(((((.....))))).....))).)..)...))).))....(((((((....))).))))....)....))).))))))[...((((..(...((((..(..(((......(....).....)))..)..((((...((((...(((((((((((.}..))))))..)))))...)))).))))....(((....((((.....}.......))))....))).))))..]....)..))))(.(.......)....(((((((((.......))))).....((.(((...(.....(((((....)))))....)....)))..))....))))...)))))).. Erythromycin Resistant Staphylococcus aureus 70S ribosome (delta R88 A89 uL22) in complex with erythromycin.; 23S ribosomal RNA 6s0x B 115 2.425 RF00001 URS0000062A7E_1280 31391518 0003735 0005840 1280 ucuggugacuauagcaaggaggucacaccuguucccaugccgaacacagaaguuaagcuccuuagcgucgaugguagucgaacuuacguuccgcuagaguagaacguugccaggc .<<<<<<<<....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<.....<<<<.<<<<....>>>>.>>>..>...>>..>>>>>>>>.. .(((((.((....((((((((.......((((...(.....)...))))........)))))).)).((.......((.((((....)))).)).......))..)).))))).. Erythromycin Resistant Staphylococcus aureus 70S ribosome (delta R88 A89 uL22) in complex with erythromycin.; 5S ribosomal RNA 6s0x a 1539 2.425 RF00177,RF01959,RF01960 URS0000D56C2C_1280 31391518 0003735 0005840 1280 auggagaguuugauccuggcucaggaugaacgcuggcggcgugccuaauacaugcaagucgagcgaacggacgagaagcuugcuucucugauguuagcggcggacgggugaguaacacguggauaaccuaccuauaagacugggauaacuucgggaaaccggagcuaauaccggauaauauuuugaaccgcaugguucaaaagugaaagacggucuugcugucacuuauagauggauccgcgcugcauuagcuaguugguaagguaacggcuuaccaaggcaacgaugcauagccgaccugagagggugaucggccacacuggaacugagacacgguccagacuccuacgggaggcagcaguagggaaucuuccgcaaugggcgaaagccugacggagcaacgccgcgugagugaugaaggucuucggaucguaaaacucuguuauuagggaagaacauauguguaaguaacugugcacaucuugacgguaccuaaucagaaagccacggcuaacuacgugccagcagccgcgguaauacguagguggcaagcguuauccggaauuauugggcguaaagcgcgcguaggcgguuuuuuaagucugaugugaaagcccacggcucaaccguggagggucauuggaaacuggaaaacuugagugcagaagaggaaaguggaauuccauguguagcggugaaaugcgcagagauauggaggaacaccaguggcgaaggcgacuuucuggucuguaacugacgcugaugugcgaaagcguggggaucaaacaggauuagauacccugguaguccacgccguaaacgaugagugcuaaguguuaggggguuuccgccccuuagugcugcagcuaacgcauuaagcacuccgccuggggaguacgaccgcaagguugaaacucaaaggaauugacggggacccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaaaucuugacauccuuugacaacucuagagauagagccuuccccuucgggggacaaagugacagguggugcaugguugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuuaagcuuaguugccaucauuaaguugggcacucuaaguugacugccggugacaaaccggaggaagguggggaugacgucaaaucaucaugccccuuaugauuugggcuacacacgugcuacaauggacaauacaaagggcagcgaaaccgcgaggucaagcaaaucccauaaaguuguucucaguucggauuguagucugcaacucgacuacaugaagcuggaaucgcuaguaaucguagaucagcaugcuacggugaauacguucccgggucuuguacacaccgcccgucacaccacgagaguuuguaacacccgaagccgguggaguaaccuuuuaggagcuagccgucgaaggugggacaaaugauuggggugaagucguaacaagguagccguaucggaaggugcggcuggau .....<<<<..[.((((.>>>>.<<<<.<<<<<...<<<<<<<.....<<<.<<<..<<<..<<.<<<<......................>>>>.>>>>>......<<........<<<<<<<..<<...<<<<<.<.<<<.<....<<<<<<....>>>>>>......>>>>......<<<.<...........>.>>>.......<.<.........>>..>.>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>...>>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>....<<<.......................>>>......<<<<<...........<<<<<........>>>>>............>>>>>.......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<.......<<<<<<.....>>>>>>.....>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<........<<<......>>>...........>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<.<<<<....<...<<<<.........>>>>...>.>>>>.>..........<<<<<<..<<<<<<<<<<<<<....>>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<..<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<........<<<......<<<<<....>>>>>.....<<<....>>>....>>>........<<<...<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<..<<.<<.........<<......>>.........>>>>.....<<<<<.....>>>>>.........>>>.......>.>>>...>>.>>>......>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<....<<....>>....>>....>>>.....>>>>>>>......<....<<<<.<<........>>.>>>>....>.....>>>>>.....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<..<<<<....<.<<<<..<<<............>>>.>>>>.>...>>>>..>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.... .....((((....[[[..)))).((((.(((((...((((((((....((..((...(((..((..((....(..(........)..)....))..)))))......(((.......(((((((..((...(((((.(.((((.....((((((....))))))......)))).......((...............))........(............)..).)))))..))))))))).(((....((...((((((((.......)))))))).))......)))..(((((((......)))...))))))).(((((............))))).((((....))))....)).)).).....(.(((...((((......))).))))).)).))))).....((.........(....)........)).......(((((...(.......(((((........))))).......)....))))).......(.(.([[[...(((((.....((.]]])).......))))))..))..)))))))))..........((([[...(.((((....((.(((.(((.((((..(((.......((((((.....)))))).....)))..))..))))).)))..(((((((((....(((((((....((..(.....((........))........)..))....).......((....)).))))))...))))).)))..)))....))))....((((((....(...((((.........))))...).))))))......{...((((((..(((.((((((((......)))))))).)))...((..]])).....)))))))))).(((......((((....))))....)))...]]]..((.(..(((((((.(...(((((..((((...(((......((........))..........((((((...(.....(.(.(....(((((....)))))......((....))...).).)...)..(.((....(((.((.(....((((((.((....))....(((......)))...)))))).....(((.....((.........((......)).........)).......((((.......)))).........))).....).).).)...))..)))......))))))...)).)...)))).(...(.((((......(((..((...(((....)))...))....)))......)))).)......(....(....((........))....)....)..)..))))).....(.(((((.........))))).).......)...))))))).)..))..(.(..((.(.((((.(((..((((((..((((....(.(((...((..............))..))).)...))))..))))))..))).))))..).))...)..)..(((((((.(....).)))))))}... Erythromycin Resistant Staphylococcus aureus 70S ribosome (delta R88 A89 uL22) in complex with erythromycin.; 16S ribosomal RNA 6s0z A 2905 2.3 RF02540,RF02541,RF00002 URS0000EEACE5_1280 31391518 0003735 0005840 1280 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Erythromycin Resistant Staphylococcus aureus 50S ribosome (delta R88 A89 uL22) in complex with erythromycin.; 23S ribosomal RNA 6s0z B 114 2.3 RF00001 URS00005C13F2_1280 31391518 0003735 0005840 1280 ucuggugacuauagcaaggaggucacaccuguucccaugccgaacacagaaguuaagcuccuuagcgucgaugguagucgaacuuacguuccgcuagaguagaacguugccagg .<<<<<<<<....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<.....<<<<.<<<<....>>>>.>>>..>...>>..>>>>>>>>. ((((((.((....((((((((.......((((...(.....)...))))........)))))).)).((.......((.((((....)))).)).......))..)).)))))) Erythromycin Resistant Staphylococcus aureus 50S ribosome (delta R88 A89 uL22) in complex with erythromycin.; 5S ribosomal RNA 6s12 A 2905 3.2 RF02540,RF02541,RF00002 URS0000EEACE5_1280 31391518 0003735 0005840 1280 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Erythromycin Resistant Staphylococcus aureus 50S ribosome (delta R88 A89 uL22).; 23S ribosomal RNA 6s12 B 115 3.2 RF00001 URS0000062A7E_1280 31391518 0003735 0005840 1280 ucuggugacuauagcaaggaggucacaccuguucccaugccgaacacagaaguuaagcuccuuagcgucgaugguagucgaacuuacguuccgcuagaguagaacguugccaggc .<<<<..<.....<.<<<<<<.......<<<...............>>>........>>>>>>..>.<<......<<<.<<<<....>>>>.>>>......>>...>..>>>>.. .((.(..((....((((((((.......((((...(.....)...))))........)))))).)).((.......(..((((....))))...)......))..))...))).. Erythromycin Resistant Staphylococcus aureus 50S ribosome (delta R88 A89 uL22).; 5S ribosomal RNA 6s13 A 2905 3.58 RF02540,RF02541,RF00002 URS0000EEACE5_1280 31391518 0003735 0005840 1280 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Erythromycin Resistant Staphylococcus aureus 70S ribosome (delta R88 A89 uL22).; 23S ribosomal RNA 6s13 B 115 3.58 RF00001 URS0000062A7E_1280 31391518 0003735 0005840 1280 ucuggugacuauagcaaggaggucacaccuguucccaugccgaacacagaaguuaagcuccuuagcgucgaugguagucgaacuuacguuccgcuagaguagaacguugccaggc .<<<<..<.....<.<<<<<<.......<<<...............>>>........>>>>>>..>.<<......<<<.<<<<....>>>>.>>>......>>...>..>>>>.. .((.(..((....((((((((.......((((...(.....)...))))........)))))).)).((.......(..((((....))))..).......))..))...))).. Erythromycin Resistant Staphylococcus aureus 70S ribosome (delta R88 A89 uL22).; 5S ribosomal RNA 6s13 a 1539 3.58 RF00177,RF01959,RF01960 URS0000D56C2C_1280 31391518 0003735 0005840 1280 auggagaguuugauccuggcucaggaugaacgcuggcggcgugccuaauacaugcaagucgagcgaacggacgagaagcuugcuucucugauguuagcggcggacgggugaguaacacguggauaaccuaccuauaagacugggauaacuucgggaaaccggagcuaauaccggauaauauuuugaaccgcaugguucaaaagugaaagacggucuugcugucacuuauagauggauccgcgcugcauuagcuaguugguaagguaacggcuuaccaaggcaacgaugcauagccgaccugagagggugaucggccacacuggaacugagacacgguccagacuccuacgggaggcagcaguagggaaucuuccgcaaugggcgaaagccugacggagcaacgccgcgugagugaugaaggucuucggaucguaaaacucuguuauuagggaagaacauauguguaaguaacugugcacaucuugacgguaccuaaucagaaagccacggcuaacuacgugccagcagccgcgguaauacguagguggcaagcguuauccggaauuauugggcguaaagcgcgcguaggcgguuuuuuaagucugaugugaaagcccacggcucaaccguggagggucauuggaaacuggaaaacuugagugcagaagaggaaaguggaauuccauguguagcggugaaaugcgcagagauauggaggaacaccaguggcgaaggcgacuuucuggucuguaacugacgcugaugugcgaaagcguggggaucaaacaggauuagauacccugguaguccacgccguaaacgaugagugcuaaguguuaggggguuuccgccccuuagugcugcagcuaacgcauuaagcacuccgccuggggaguacgaccgcaagguugaaacucaaaggaauugacggggacccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaaaucuugacauccuuugacaacucuagagauagagccuuccccuucgggggacaaagugacagguggugcaugguugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuuaagcuuaguugccaucauuaaguugggcacucuaaguugacugccggugacaaaccggaggaagguggggaugacgucaaaucaucaugccccuuaugauuugggcuacacacgugcuacaauggacaauacaaagggcagcgaaaccgcgaggucaagcaaaucccauaaaguuguucucaguucggauuguagucugcaacucgacuacaugaagcuggaaucgcuaguaaucguagaucagcaugcuacggugaauacguucccgggucuuguacacaccgcccgucacaccacgagaguuuguaacacccgaagccgguggaguaaccuuuuaggagcuagccgucgaaggugggacaaaugauuggggugaagucguaacaagguagccguaucggaaggugcggcuggau ...........<.<<<<......<<<..<<<<.<..<<<<<<<.....<<<.<<....<<..<<..<<<......................>>>..>>>>.......<<........<<<<<<...<<...<<<<..<..........<<..<<....>>..>>............................................................>..>>>>..>>.>>>>>>.<<<....<<<....<<<<<<.......>>>>>>..>>>......>>>..<<<<<<<......>>...>>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>....>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>..........................................<<...........<<<<<........>>>>>............>>.............<.((.....<<<<.....<<..))>>.......>>>>..>....>.>>>>.>>>..........<<<((.....<<<....<<<.<<<<<<..<<....<<<.......<<<<<<.....>>>>>>.....>>>......>>.>>>>>>...<<..<.<<....<.<<<<...............<<........>>.........................<<....>>.>>>>>....>>.>...>>...>>>....>>>....<..<<.........<<<..........>.>>......>>..>..........<<<<<<..<<..<<<<<<<<......>>>>>>>>..>>...<...)).>.....>>>>>>.>>>..<<.......<<<....>>>.....>>...>>>>.>.<....<<<<<<<.....<<<<<..<<<<<...........<<........>>..........<<<<<<<......<<<<.......<<<<<....>>>>>.....<<.....>>......>>.>>..<<.<<<...<<<.........<<<<<.<<<....>>>...<<<......>>>....>>>>>......<<..<....<........<<......>>.......>...>......<<<<.......>>>>.........>>...............>>>.>>>>>....>>>>>>>.........>>>>>.......<<<<<.....<<<..........................>>>.....>>>>>.............<.<..<..........>..>.>..........>>>>>......<<<<<<.........>>>>>>............>>>>>>>....>.............<<<<.<<.......<<..<<<<....<.<<<<..<<..............>>.>>>>>....>>>>..>>.......>>.>>>>...............<<<<<............>>>>>.... .....[.[...(.(((...].].((((.(((((...((((((((....((..(....(((..((...(....(..............)....)...)))))......(((.......((.((((..((...(((((.(.(..(.....(((.((....)).)))......)..).........(..(........)..).........(............)..).)))))..)))))).)).(((....((....(.(((((.......)))))..).))......)))..((((.(((....)))....))))))).(((((.(.........)))))).((((....)))).....).)).).....(.(((...((((......))).))))).)).))))).....(.........................).......(((((...(.......(.(((........))).).......)....))))).......(.(.([[[...(((((.....((.]]])).......))))))..))..)))))))))..........((([[...(.((((...(((.(((.((..((....(((.......((((((.....)))))).....)))......)).)).)))..(((..((((....(((((((....((..(.....((........))........)..))....).......((....)).))))))...))))...))..))))...))))....(.(((.....(...(..(..........).)...)..))).)......{...((((((..(((((((((((((....)))))))))))))...(...]].).....))))))))))..((........((....))......).)...))).)((....(((((((.....(((.(...((((...((......((........))...........(.(((...(....(((..(....(((((....)))))......((....))...)..)).).).((.(.....((...(.(....(((((((((....)))...(((......)))...))))))......((......(.........((......)).........)........((((.......)))).........).).....).).......))...))).....)))..)...))....))))..(...(.(((((.....(.(..((................)).....)).....))))).)......(....(((...(........)...)))....)..)..).)))......((((((.........))))))............)))))))....))..(.(.....(.((((.(....((((((..((((....(.((((..((..............)).)))).)...))))..))))))....).))))..)......)..)..(((((...(....)...)))))}... Erythromycin Resistant Staphylococcus aureus 70S ribosome (delta R88 A89 uL22).; 16S ribosomal RNA 6s47 AA 3149 3.28 RF02540,RF02543 URS0000B21DCE_4932 31299085 0003735 0005840 4932 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........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((.((((.((((((((...({((((......)))))[[(...).(((....}]])))....))))))))...)))).))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((......((((.(....).)))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...(..(((.....)))..).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((.(((....(.........)....))).........((......))...)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...((((((...((.....)).))))))....[[(((.((...((....(((....))).........(....(.....)......)....))....))...(((((........)))))]]((((..(((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((((.(...)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.........)))))))....((((.....((((..((((........))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).).......(((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).))....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......(((((..(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).)))..)))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(.(.((..)..).).)..)))))...)))....)))).)))))).))))).. Saccharomyces cerevisiae 80S ribosome bound with ABCF protein New1; 28S ribosomal RNA 6s47 AB 121 3.28 RF00001 URS000055688D_4932 31299085 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Saccharomyces cerevisiae 80S ribosome bound with ABCF protein New1; 5S ribosomal RNA 6s47 AC 158 3.28 RF00002 URS00001BF64E_4932 31299085 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Saccharomyces cerevisiae 80S ribosome bound with ABCF protein New1; 5.8S ribosomal RNA 6s47 BA 1707 3.28 RF01960,RF01959,RF00177 URS0000EEAD01_4932 31299085 0003735 0005840 4932 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccaacggggccuuuccuucuggccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucau ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[..................<.....<<.<<<.....>>>.>>......>.........<<<<<..<<....>>..>>>>>[...((((((......<<<<<<<<<<......>>....<<......>>)))))).....]...<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<.<<....<..........>....>>..>>......<<..<...........>..>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..))))))]]]].........[[[{{.......{{...[[[.[[....<<<<<<.<<<<..>>>>.>>>>>>....<<<<<..>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>..........[[..((((((((....>>>>>>>>.)))))))).]]......]]....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<<.....>.>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<.<......>....<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>......<....<<<<<<..........>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<.>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>....... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....))..........((((..((....))..)))).(.(.((((((......[[[[[.[.((.(...))).....(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....((..(...(...(....)...)...)(.)))......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.((((())))).)))))).....((((()))))....(((((.((.......((..((.......)).(((.....)))....))......)).))..)))..........((..(((..(((......]]]]]].)))..))).))......))...(((.(((..(...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)..)))..))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.((.((....))...(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...(((.)))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>...... Saccharomyces cerevisiae 80S ribosome bound with ABCF protein New1; 18S rRNA (1707-MER) 6s8b U 44 2.41 URS0001A24B3B_930945 32730741 930945 guuaagucugguuucccuccaggguaucuaagcuuugaaaaaaa ............................................ ............................................ Cryo-EM structure of the Type III-B Cmr-beta bound to cognate target RNA and AMPPnP, state 1; Cognate target RNA (46-mer) 6s8b V 49 2.41 URS0001A24B53_930945 32730741 930945 auugaaaguucaaagcuuagauacccuggagggaaaccagacuuaacac ................................................. ................................................. Cryo-EM structure of the Type III-B Cmr-beta bound to cognate target RNA and AMPPnP, state 1; crRNA 6s8e U 44 3.1 URS0001A24B69_32630 32730741 32630 guuaagucugguuucccuccaggguaucuaagcuuugaacuuuc ............................................ ............................................ Cryo-EM structure of the type III-B Cmr-beta complex bound to non-cognate target RNA; Non-cognate target RNA 6s8e V 47 3.1 URS0001A24B53_930945 32730741 930945 auugaaaguucaaagcuuagauacccuggagggaaaccagacuuaac ............................................... ............................................... Cryo-EM structure of the type III-B Cmr-beta complex bound to non-cognate target RNA; crRNA 6s91 U 36 2.68 URS0001A24B3B_32630 32730741 32630 guuaagucugguuucccuccaggguaucuaaguuga .................................... .................................... Cryo-EM structure of the Type III-B Cmr-beta bound to cognate target RNA and AMPPnP, state 2; Cognate target RNA 6s91 V 48 2.68 URS0001A24B53_930945 32730741 930945 auugaaaguucaaagcuuagauacccuggagggaaaccagacuuaaca ................................................ ................................................ Cryo-EM structure of the Type III-B Cmr-beta bound to cognate target RNA and AMPPnP, state 2; crRNA (48-MER) 6sgc A1 1697 2.8 RF01960,RF01959,RF00177 URS0000704D22_9986 31768042 0003735 0005840 9986 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucgacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgcccggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcggccguccccugcucggcgccggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgaccccggucggcguaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggugcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<....<<....<<<<<........<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<<<....>>>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<<.>>>>>>>>.>>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....<<<<<<<<<.<<<....>>>..>>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<....<<<.<<<..>>>.>>><<<<<<<.......>>>>.>>>.<<<<<<.<.......<<...<.......>.<<<<.>>>>...>>......>.>>>..>>>........<.<<.<<<<<<.................>>>>>>.>>.>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<<....>>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<........<<........>>..........<<<<<......<<<<<........<<.<<<........>>>.>>......>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<..>>>>.>>>>>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>>......>>>>>......>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<.<<<<<<<<<..>>>>>>>>>...>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..((....((((....((...((.....((.(((.....))).))......))......)).((((...(((((......)))))...))))((..(((((...(......)..)))))......)).(.((((.((((.))))))))).).)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).).....(((((((((.(((....)))..)))))).)))....(.((..(...........)..))......)..((((([[......((((.....((..]])).......)))).)))))..)))))).)))..[......(.([[...(.(.((...(((..(....(((.(((()))).))).(.(((.........)))..)..((((((.(.......((..((.......)).(((.)))....))......).)))..)))........(.((.((((((.................)))))).)).)....)....(((..(...(...((((..(((.((((((((...((........))......)))))))).))).......((....))...))))..)...)...))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.(((((....))))))))))).)..)))...((..]]))...))...].))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((..((........))..))....).)))))...((.(((...(.((((((.(..(((.(((((....)))..(.((......)))...)).)))....(((...(...((((..((((((((((((..)))).))))))))..))))..).....(((((.....)))))........))).)..))).))).....).))))).....).)))))...)).)))).))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..((((.((...((((((((((((.(...)..)))))).).)))))...)).))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}........ Rabbit 80S ribosome stalled on a poly(A) tail; 18S ribosomal RNA 6sgc i1 10 2.8 31768042 9606 aaaaaaaaaa .......... .......... Rabbit 80S ribosome stalled on a poly(A) tail; polyA mRNA 6sgc 54 3603 2.8 RF02540,RF02543 URS000197CF67_9986 31768042 0003735 0005840 9986 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggaaauguggcguacggaagacccacuccccggcgccggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcgcgguccggccgugccggcggggcggaucucccgcucccgucggcgggggaccgccccccggccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggccccggcggggaagguggcccgggggccccggguguuacagccccgccccggcagcagcagcucgccgaaucccggggccgagggagcgagacccgugcgccgcgcucuccccccucgggggggccgggccaccccucccacggcgcgaccgcuggggcggacuguccagugcgccccgggcgggucgcgccgucgggcccggggggccacgcgucccccgcgagcgcacggggucggcggcgaugucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcuacgaaagccgccguggcgcaaugaaggugaaggccggcggcgcgccgccggccgaggugggaucccgaggccuuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcgaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccaaaguuucccucaggauagcuggcgcucuccgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcugguguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggaugguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgcuggcagucggcagagcgagaaagagaguggcgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucagccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcuggcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacaugagagguguagaauaagugggaggcccgggccgccggugaaauaccacuacucugaucguuuuuucacugacccggugaggcgggggggcgagccgggcucucgcuucuggcgccaagcgcccggccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauagcgccggagccucgguuggccucggauagccggucccccgccgggguccggugcggagagcccuucgucccgggaaacggggcggccggaaagggggccgcccucucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcugcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>>..<<<<<<<<<....<<<<<<<<..<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>...>>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<......>>>..................................<<<<<<<<..<<<.<....<<<<<<<<.<<<.....<<<<<<<<<<....<<<<<<<.<<<<<.<<<<<<<.<<<<<<<<<......>>>>>>>>>>>>>>>>>>>>>>>>>...>>>.>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<.<<<<<<<<<<<<<<<...<<..<<<..<<<<<<<......<<<<<<<<.>>>>>>>>.......>>>>>>>..>>>.........>>>>>>..>>>>>>>>>>>.....<<.......>>.........<...<<<<<<..>>>>>>...<.<<..<<<.<<<<<<<<<<<<<<<<<<<<<<<.<<<<..>>>>.>>>>>>.>>>>.>>>>>>>>>>.>>>...>>>>>.>................>.........>>.>>>>>....>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<.....>>>>.....>>>...<<....>>...<<<<<<<<<<..>>>>>>>>>>..<<<<<...<<<..<<<....[[.[[.>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<...<<<.<<<<<<<<<...<<<....<<<..<.<<<..<<<<<<.........>>>>>>>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.........>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<.....<.........>.....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<....................]].]].............>>>>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<<<<<...>>>>>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<..<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<...............<<<<<....<....>.....>>>>><<.<<<<<<<<<<<.>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<<...<.<<<<..........<<<<<..<<<<..>>>>............>>>>>.>>>>.>....>>>>>>>>...<<<<<.....<<<<..<<.<........>.>>..............<<<<<<<<<..>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.((.((>>....>>>>>>>...<<<..<<<<.......>>>>..>>><<<<....>>>>>>)))).....<<<<<<<..<<<..)))))).>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<....<<<<<.................>>>>>..<<<<....<<<<....<<.<<<<<<<]]].>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.<<<<<....<<<<....<<<........<<<<<...<<<<.>>>>..>>>>>.......>>>...<<<..<<<<....<<<<<<<<<........>>>>>>.>>>...>>>>..>>>..............>>>>.....>>>>>.<<<<<.<.............>....<<.<<<<<<<.<<.....<<<<....<<<<<.>>>>>...>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..(((((((((((.....)))))).))))....))))....(((((((((....(.((((((..((((((((..({((((......)))))....[[(...).(((....}]])))...).)))))))...)))))).)...)))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....((((((((((.(..(((((((.(((((.(((((((.(((((((((..()..)))))))))))))))))))))))))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((..(((((((......((((((((.)))))))).......)))))))..))).........))))))..))))))))))).....((.....{.))...........(.(((((.().)))))...(.((..(((.((((((((((((((((.((((((.(((....))).))))))..)).))))))))))).)))...))))).)............[.)..........))).)))))...)))))...)))))))).<((((........))))((((((....(((((((((((((..(((..(((((.....))))..)..)))...((....))...((((((((((()))))))))))..(((((...(((..(((]...[[.[[[)))..)))....))))).(((((((((.((((......))))))))))).))....)))))))))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)<)))...(((..((.((.......B)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((...(((.((((((((....(((....(((..(.(((..(((.(...........).)))))).)..)))..)).)....))))))...(((((((((.(......))))))))))....))))))))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.....A.((.((.(((...................))).........((......))...)).))...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((........}.........].]].]].............)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...((..(.(((....))).....)....((.((((.((((...)))).))))))......))....))...(((((........)))))]]((((....(((((...(((((((....)))))))..((((....)))...(...((((((...(((((((((((((((((((((((...{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((.)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.(((((((((.(((((((((....((((.............((....((..))..............))....)))).....)))))))))...(((((.....((((..((.(........).))..............(((((((((())))))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..b.))..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}..)))))..)).))...))))...)))).((((...((((.....a.......))))...))))..)))...).)))))).(((((.(..((((....(((.........((((...((((.))))..))))........)))...(((..(((.....(.(.(((((........)))))..).)....)))..)))..............))))..)..))))).(((((.(..(.......)..)....((.(((((((.((.....((((.(..(((((.)))))..)))))....))....)))).))).))..))))).. Rabbit 80S ribosome stalled on a poly(A) tail; 28S ribosomal RNA 6sgc 74 119 2.8 RF00001 URS000002B0D5_9986 31768042 0003735 0005840 9986 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))). Rabbit 80S ribosome stalled on a poly(A) tail; 5S ribosomal RNA 6sgc 84 151 2.8 RF00002 URS00004B2C76_9986 31768042 0003735 0005840 9986 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcagguugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<<<<....>>>>.....<.<<<......>>........>>>..>...>>>....<<<..>>><<<<<<<<<....>.>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]]........)))..)...)))....((....))((((((((.......)))))))).................... Rabbit 80S ribosome stalled on a poly(A) tail; 5.8S ribosomal RNA 6sgc 23 76 2.8 RF00005 URS000197CF6C_9986 31768042 0030533 0006412 9986 gcccgcauagcucagccggnagagcaucagacunuunaucugaggnnnnagggnucangucccuguucgggcgcca <<<<<....<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>..>>>>>.... (((((.(..((((........))))..(((.........)))......(((((.......)))))).))))).... Rabbit 80S ribosome stalled on a poly(A) tail; tRNA (Lys3) 6sgc 33 76 2.8 RF00005 URS000197CF6C_9986 31768042 0030533 0006412 9986 gcccgcauagcucagccggnagagcaucagacunuunaucugaggnnnnagggnucangucccuguucgggcgcca <<<<<....<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>..>>>>>.... (((((.(..((((........))))..(((.........)))......(((((.......)))))).))))).... Rabbit 80S ribosome stalled on a poly(A) tail; tRNA (Lys3) 6sh8 U 32 3.14 URS0001A24B3B_32630 32730741 32630 guuaagucugguuucccuccaggguaucuuga ................................ ................................ Cryo-EM structure of the Type III-B Cmr-beta bound to cognate target RNA and AMPPnP, state 2, in the presence of ssDNA; Cognate target RNA 6sh8 V 48 3.14 URS0001A24B53_930945 32730741 930945 auugaaaguucaaagcuuagauacccuggagggaaaccagacuuaaca ................................................ ................................................ Cryo-EM structure of the Type III-B Cmr-beta bound to cognate target RNA and AMPPnP, state 2, in the presence of ssDNA; crRNA 6shb U 43 3.07 URS0001A24B3B_32630 32730741 32630 guuaagucugguuucccuccaggguaucuaagcuuugaaaaaa ........................................... ........................................... Cryo-EM structure of the Type III-B Cmr-beta bound to cognate target RNA and AMPPnP, state 1, in the presence of ssDNA; Cognate target RNA (43-MER) 6shb V 49 3.07 URS0001A24B53_930945 32730741 930945 auugaaaguucaaagcuuagauacccuggagggaaaccagacuuaacac ................................................. ................................................. Cryo-EM structure of the Type III-B Cmr-beta bound to cognate target RNA and AMPPnP, state 1, in the presence of ssDNA; crRNA (49-MER) 6sic U 42 3.52 URS0001A24B3B_930945 32730741 930945 guuaagucugguuucccuccaggguaucuaagcuuugaaaaa .......................................... .......................................... Cryo-EM structure of the Type III-B Cmr-beta bound to cognate target RNA; Cognate target RNA 6sic V 48 3.52 URS0001A24B53_930945 32730741 930945 auugaaaguucaaagcuuagauacccuggagggaaaccagacuuaaca ................................................ ................................................ Cryo-EM structure of the Type III-B Cmr-beta bound to cognate target RNA; crRNA 6sj6 A 2585 3.23 RF02540,RF02541,RF00002 URS00001C3329_93061 32245971 0003735 0005840 93061 uuaaguuauuaagggcgcacgguggaugccuuggcacuagaagccgaugaaggacguuacuaacgacgauaugcuuuggggagcuguaaguaagcuuugauccagagauuuccgaauggggaaacccagcaugaguuaugucauguuaucgauaugugaauacauagcauaucagaaggcacacccggagaacugaaacaucuuaguacccggaggaagagaaagaaaucgauucccuuaguagcggcgagcgaaacgggaagagcccaaaccaacaagcuugcuuguugggguuguaggacacucuauacggaguuacaaaggacgacauuagacgaaucaucuggaaagaugaaucaaagaagguaauaauccuguagucgaaaauguugucucucuugaguggauccugaguacgacggagcacgugaaauuccgucggaaucugggaggaccaucuccuaaggcuaaauacucucuagugaccgauagugaaccaguaccgugagggaaaggugaaaagcaccccggaaggggagugaaauagaaccugaaaccgugugcuuacaaguagucagagcccguuaaugggugauggcgugccuuuuguagaaugaaccggcgaguuacgauuugaugcaagguuaagcaguaaauguggagccguagcgaaagcgagucuguagggcguuuaguauuuggucguagacccgaaaccaggugaucuacccuuggucagguugaaguucagcugaauggaggaccgaaccgacuuacguugaaaagugagcggaugaacugaggguagcggagaaauuccaaucgaaccuggagauagcugguucucuccgaaauagcuuuagggcuagccucaagugaugauuauuggagguagagcacuguuuggacgaggggccgguuaccgaauucagacaaacuccgaaugccaauuaauuuaacuugggagucagaacaugggugauaagguccguguucgaaagggaaacagcccagaccaccagcuaaggucccaaaauauauguuaaguggaaaaggauguggcguugccgugacacugcgccgaaaauguaccggggcuaaacauauuaccgaagcuguggauuguccuuuggacaaugguaggagagcguucuaagggcguugaagcaugaucguaaggacauguggagcgcuuagaagugagaaugccggugugaguagcgaaagacgggugagaaucccguccaccgauugacuaagguuuccagaggaaggcucguccgcucuggguuagucggguccuaagcugaggccgacaggcguaggcgauggauaacagguugauauuccuguaccaccuauaaucguuuuaaucgauggggggacgcaguaggauaggcgaagcgugcgauuggauucguugauuucacacugccgagaaaagccucuagauagaaaauaggugcccguaccgcaaaccgacacagguagucaagaugagaauucuaaggugagcgagcgaacucucguuaaggaacucggcaaaaugaccccguaacuucgggagaaggggugcucuuuaggguuaacgcccagaagagccgcagugaauaggcccaagcgacuguuuaucaaaaacacaggucucugcuaaaccguaaggugauguauaggggcugacgccugcccggugaguaaacggcgaagguagcgaaauuccuugucggguaaguuccgacccgcacgaaaggcguaacgauuugggcacugucucaacgagagacucggugaaaucauaguaccugugaagaugcagguuacccgcgacaggacggaaagaccccguggagcuuuacuguagccugauauugaaauucggcacacuguguuggcuuucuaacccgcaccacucguggugggagacagugucaggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcucaaagguucccucagaaugguuggaaaucauucauagaguguaaaggcauaagggagcuugacugcgagaccuacaagucgagcagggucgaaagacggacuuagugauccggugguuccgcauggaagggccaucgcucaacggauaaaagcuaccccggggauaacaggcuuaucucccccaagaguucacaucgacggggagguuuggcaccucgaugucggcucaucgcauccuggggcuguagucggucccaaggguugggcuguucgcccauuaaagcgguacgcgagcuggguucagaacgucgugagacaguucggucccuauccgucgugggcguaggaaauuugagaggagcuguccuuaguacgagaggaccgggauggacauaccucugguguaccaguugucgugccaacggcauagcuggguagcuauguguggacgggauaagugcugaaagcaucuaagcaugaagccccccucaagaugagauuucccaauuauaagaucccucaaagaugaugagguuaauagguucgagguggaagcauggugacauguggagcugacgaauacuaaucgaucgaagacuuaau <<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<.<<.((..((.>>......<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<<<<.<<<.........>>>.>>>.>.>>>....<<<<<......<......>.......>>>>.>.........<<..>>...<<<<......<<.....>>.....>>>>...(((....<<.<<<<<....>>>>>.>>......<<<<...<..................<<<<<<<<..<<<...<<<<<......>>>>><<......((......>>.))...>>>....>>>>>>>>......>......>>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<......>>>..................>>>>>>>>>>>.......<<<<..<<<<......>>>>..>>>>...<............>.<<<<<<....<<<<<<<.<.<<...<<<...<<<.....>>>...>>>...<......>....<<...>.>.......>>>..>>>>>>>..<<....<<<<<<<.....<<<<<<<<<..<<<....<<<<<..>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>....>>..<<<<<<....<<<<<....>>>>><<<<<<<<<...<<<<<<<<<............<<<<<<<...................>>>>>>>............>>>>.>>>>>..>>>>>>>.>>..<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<<<<.....(((.((...........<<...<<<.<.<.....>.>.>>>..>>...........>>>.....)).))).>>>...>>>>>>>.<<<<<<...>>>>>>.....>>>>>><.<<<<<<<.........<<<<<.<......>.>>>>>......>>>>>>>..>.....>>>>>><......<.....<<<<<.........>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>.....(<<<<.<.<<.<<<...<<<....>>>...>>>..>>>...<<<<<........>>>>>).<<<<<.............<<...<<<<....<.....<<<...............................>>.>.....>........>>>.>.>>........>>>>>>>>>..>>.....<<......>>>>>>>.<<<.......>>>..>>>>..<<<<....<<<<<<<<..<................<<<<....<....>.....>>>>.<<<<<<<.<<........>>.>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<......>>.......>>>>>>>..<<<<.<<<............>>>.....................<<<.......>>>............>>>>...>>.>>>>>>>.....>..>>>>>>>>.>>>>.>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<..<<<<<<<<<..<<<.<.<<<.......>>>>..>>>.....<<.<<<<<....>>>>>>>.....>>>>>>>>>...>>>>..<<<<.....>>>><<<.<<...........>>.>>>..<<...<<<<<<<....<<.............>>......<<.[.(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<.<<<.<.<<<...<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>......>>>...>...>>>..>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<.....<....>....>>>>>>>.<<<<<...<<.<...<<<<<<<<<........>>>>..>>>>>...>.>>.>>>>>...<<<.<..<<<<.............>>>>...>>>>.>>>>.......>>>>>>>.........<<<.<<<<.........>>>>....<<<<<<<<.<<<.....<<<<....>>>>....>>>..>>>>>.>>>....>>>....>>>>>>. ((((((......((((((((((.....(((..(((((((((((.(......((((((.......[)))...].(((((....(((.......))).......)))))...))).....((....)).((((((........)))))).(((((.(.............).))).)).).....(((((......(...[..).......)))).).........((..))...((((......((.]...)).....))))...(((....(......(....)......)......(((((..(......................(((.(.(.(...(((((......))))).[(...).(((.....].)))...).)...).)))...........)..)..)))).....(((((((...........))))))).......((((..[[[[))))...)))......)).))))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((..((((..[...))))..)))).{.(.(........).).((((((..(.(((((((.(......((....(((.....)))....))...((....))..((((...))))........)..)))))))..((.(...((((((.....((((((((((.((.(....((((..))))....){.))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))(((((((((.....(((((((.....(.(....((.((((...................)))).))...)..).....)))).)))....))))))).))..((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((.(((.....(.....((..........(...).........))...........]]].)...))).))))))...)))))))((((((.....))))))....))))))(((((((((.((.......((((.((....))]))))....)).))))))).)).....))))))(......((....((((((.......))))))((((....(((...((..(((((((...((.....)).))))))....[[((((..(...((....(((....)))....))...)....((((..........))))]].(((..............((...(.((....((.....(.................................).....))(..).....)).)..)).........))).)))).))).....((......))..))).(((.......)))..))))..((((....((((((((.((..(....(.......(((((....(.[..).....)))))(((((((.((........)).)))))))............((((((.((.}.((.........))...(((((((.....(((....))).......))))))).]((((...(..(........))..........(.............((.......)).....).......))))...))..)))))).)..))).)))))))).)))))).....)).[..(((((.....}].)))))..((((((((.(((.((......((((.(((((...((((..(((((((((...((.(...(.......)...).))......((.(.((.(..).)).))).....)))))))))...))))..(((......[)))(((..(..........])..)))(([[......[.......(...............)......[.)..(((.].......]......((((..(((...{..)))..)))).(((....))).]]))).......(((((((.((..]]]]..))))))))).....)}.......)))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......(.((.(.((((..(((((..............))..))).(((((.....))))).....))))...)...))..).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..((.(((......(....).....))).)).((.((...(.((...((((((.(((......))).)..)))))...)).).)).))...(((....((.................))....))).))))..]....)))))))((())....(((((((((.......)))))....((((((((.(((.....((........))....)))..))))).)))...))))...))))))). Cryo-EM structure of 50S-RsfS complex from Staphylococcus aureus; 23S ribosomal RNA 6sj6 B 112 3.23 RF00001 URS0000062A7E_93061 32245971 0003735 0005840 93061 cuggugacuauagcaaggaggucacaccuguucccaugccgacacagaaguuaagcuccuuagcgucgaugguagucgaacuuacguuccgcuagaguagaacguugccagg .<<..<......<<.<<<<<.....<<<<<..............>>>..>>....>>>>>..>>.<<.....<<<<.<<<......>>>.>>>..>...>>....>.>.>.. ................((.(.....((.(((............)))...))....).))......((.......(..(.(.......))..).......))........... Cryo-EM structure of 50S-RsfS complex from Staphylococcus aureus; 5S ribosomal RNA 6sjd D 17 3.29 URS0001A24B5A_9606 32703884 9606 ugcgacagucgguagca ................. ................. ZC3H12B-ribonuclease domain bound to RNA; RNA (5'-R(*UP*GP*CP*GP*AP*CP*AP*GP*UP*CP*GP*GP*UP*AP*GP*CP*A)-3') 6skf Aa 1463 2.95 RF00177,RF01959,RF01960 URS00021ED992_311400 32555463 0003735 0005840 311400 auucnggnugauccugccggaggccacugcuaugggggucngacuaagccangcgagucauggggcgcgcgcgcgcaccggcggacggcucaguaacacgucgguaaccuacccucgggagggggauaacccngngaaacuggggcuaaucccccauaggccugagguacuggaagguccucaggcngaaaggggcaugcccgcccgaggaugggccggcggcngauuagguagnuggugngguaacggcccaccaagccgaagaucgguacgggccaugagagugggagncnggaganggacacugagacacgnguccaggcccuacggggcgcagcaggcgcganaccucngcaaugcgggcaacngcgacggnnggacccccagugccguggcagccacggcuuuuccggaguguaaaaagcuccgggaauaaggncugngcaaggnngguggnagccgccgcgguaanaccggcggcccgaguggungcngcuauuauugggccuaaagcgucnguagccnggnccguaagucccuggcgaaaucccacggcucaacnguggggcuugcuggggauacugcgggccuugggacngggagaggccggggguaccccugggguaggngugaaauccuauaaucccagggngaccgccagungngaaggcgccnggcuggaacgggucngacggugagggacgaaggccaggggagcgaacnggauuagauacccggguagucnuggcuguaaaggaugcggncuaggugucgggcgagcuucgagcucgcccggugccggagggaagcnguuaagncngccgccuggggaguacggcngcaangnugaaacuuaaaggaauuggcgngggagcacuacaaggnguggagcgugcgguuuaauungaunnaacgccgggaaccucaccgggggngacggcaaggccaggcugaaggucuugccggcgagaggangugcauggcngcngucagcucguacnguganncguccacuuaagugugguaacgagngagacccgcgcccccaguugccaguccuccccgcuggggaggaggcacucuggggngaccgccggcgauaagccggaggaaggagcgggngacgguaggucaguaugccccgaaacccccgggcuacacgcgcgcuacaaugggcgggacaaugggauccgacccngaaaggggaagggaauccccuaaacccgcccucaguucggaucgnggncugcaacucnnccgcgugaagcuggaaucccuaguacccgcgugucaucaucgcgcggcgaauacgucccugcuccuugcacacacngnccgncanuccacccgagcgggguccgggugaggccuggucucccuucggggaggccgggucgagccugggcuccgugagnggggagaagucguancaagguagcnguaggggnnccuacggnungauc ...<<<<<.[.((((>>>>>.<<<<<<<<<..<<<<<<.<<......<<<.<<<..<<<..<<.<<<<<..>>>>>.>>>>>......<<........<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<<<<<.<<......>>>>>>>>>>>.....<<<<..>>>>.>>>>>>>..>>>>>>>>>.<<<....<<<...<<<<<<<.......>>>>>>>.>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<............>>>>>.<<<<<..>>>>>...>>>>>>......<<.<<<....<<<<....>>>>..>>>>>>>.>>>>>>..<<<<<<<<.>>>>>>>>...<<<<<<<<.......>>>>>>>>.....<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<....<<<<<<<<.....>>>>>>>>...>>>>>>>..>>>>>>>>>>...<<<<<<.....<<<<<<<<<..<<<<<<<<<..<<<......>>>.....>>>>>>>>>..>>.......<<....>>.>>>>>>>....>>>.>>>...>>>...>>>>...<<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>>.........<<<<<<..<<<<<<<<<<<<<<.....>>>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<...<.....<<<.<<<.......>>>.>>>...>...<<.<<<..<<<<<<<<.....<<<<<<.<<....>>...<<<<......>>>>..>>>>>>....<<<<<.<<<<<<<..<<<..<<<<<<<<...>>>>>>>>>>>...>>>>>>>.....<<<<<.....>>>>>........>>>>>.....>>.>>>...>>>>>>>>....>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>.....<<<<<<<.......>>>>>>>.......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<..<<<<<<<<<<<<<....>>>>>>>>>>>>>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... ...((((..[.[[[..)))).(((((((((..((((((.(((.....(((.(((..(((..((.(((((()))))).)))))......(((.......(((((((..((...(((((((.(((((....((((((....)))))).....)))))...(((((((((.((......))))))))))).....((((..)))).)))))))..))))))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((((((.))))))))....(((((((.......)))))))......((((([[....(.((((.....((..]])).......))))))))))..)))))))))..........((([[...(.(((....(((.(((((((.((((((((((.....(((((((.....)))))))....))))))))..)))))))))..(((((((.....(((((((((..((((((((...((........))......))))))))..)).......((....)).)))))))....))).)))..))))....)))...(((((((...((...((((.........))))...))))))))).....{...((((((..((((((((((((((.....))))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..((((((((((......((........))..........(((((((.....(...(((.((((.....)))).)))..)....((.(((...(.((((((....((((((.((....))...((((......))))..))))))....(((((.(((((((..(((..((((((.(...).)))))))))...)))))))..(....(.(.....).).......)..)))))....))).)))....).)))))....)))))))...)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..)))))......(((((((.......))))))).......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((..(((((((((((((....)))))))))))))..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Cryo-EM Structure of T. kodakarensis 70S ribosome; 16S rRNA 6skf BA 2929 2.95 RF02540,RF00002 URS00021ED901_311400 32555463 0003735 0005840 311400 cccgguggcaacuaagcngccuggnggauggcucggcucggggcgcngacgaanngcguggcaagcugcgauaagccccggcgaggcgcaggcagccgucgaaccggggaugccngaaugggaccucccgcggcuugccgcacucccagucgggagggggaacgcggggaauugaaacaucuuaguaccngcaggaaaagnaancaaaagcgaugccguuaguaggggcgacngaaagnggcacagggcaaacugaaccccgggccgaaagguucgggngauguggnguuguagggcccgcggaggagcccugggggcgaagcngaaguccgcuggaacgcngcgncggagagngugaaagcccnguaggcguaagcccccgagcuccugcggugucccugaguacnnucggucggauaucnggcgggaagcugggaggcancggcucccaacccuaaauacgucccgagaccgaungcgaacuaguacngugngggaaagcugaaaagcacccngggaggggggngaaaagagccugaanccaggcggngauaggagggngcngcccgaaaggguugacccuccccgaaggaaacacgggcgacngnggaguacgaggggaggugaccgggguugcaccguccgncuuggaucacggggcanggaguucacccgagcggcgagguuaagggggucaacccngaagncgcanggaaacngacagguccgcagcccguagggngngggacgnggugngaaagcgccnggagucgcucgggugagaccnnaagcnggucgaucuagcccggggcngggugaanucccucaacagagggnuggaggccngcuaggggugnugncgngcanuucgcucccgugaccccgggcuaggggugaaangccaaucgaggcnggcgaungcugguucccgncgaauuaucccccaggauagcccggccggagguaggcagugggguagagcacugauuggggguuuagggggcgaaagccuccggcucccugucaaacuccgaacccacugccgccguagauggccggaguaggggggcggnguaagccgucacccgagaggngaacaacccagaccgggguuaaggccccaaagugccggcuaaguguuacuccaaagggugucccuggccuuagacagcggcccgucgaggucaggggccccgaaaauggncggggcuuaagccggccgccgagaccccggcgcacggacngauugguccgugancggguaggcgggcgugcnganggggcggaagccgggcngugagguccgguggaccngucgguauugcggauccugcngngnguagcagcauagccgggugagaauccnggcngcnguaggggccaggguuccacggcaauguucgucagcnguggguuagncgguccuaacccgacccguaacucggcgucggggaangggaaacngguuuauauucccguacngcggnggnaggugcngcaacgcaagcccgaggggugacgccucgggguaggcggaccgguccacaaggccggcuaagcguauaagcccggggagugcnguaauggcgagaaccgggugaaagcgcgaauggccucccguaagggggguuccgncgaucccuggggcccgugaaaagccccucgggaacgauccaccgcgaccguacngagaaccgacacuggugccccugggngagaagccuaaggngugucgggngaaacccagcngagggaacunggcaaauuggccccguaacuucgggagaaggggugccugcggguguguaacccgcaggucgcagugacuagnggggccngacugnuuaguaaaaacacaggucccagcuagccngaaagnguuuguacugggncngacgccugcncagngccgguaugugaagcccggguacaaccgggugaagcaccgnuaaacngnngggguaacuauaaccnucuuaagguagngaaauucnuugucgguuaaaugncgacnugcaugaauggcguaacgagguccccacuguccccggcuggggccnggngaaaccucugccaggcgcauaugccugngaccucnggugggaancgaagaccccauggagcuuuacugcagccugccguugccguacggcggggggugcgcagcguaggcgggaggcgucgaagcccgcccuccggggcggguggagccgcccaugagacaccgcccacccucugccguacggcuaacccgcggaagcgnggacagcgguaggugggcaguuuggcugnggcggcacacccucgaaaagguaucnagggngcccnaaggucggcucaggcgggucuccgccguagagugcaagggcaaaagccggccugacuggaccnguaacagaggcggguccagccgcgaaagcguggccuagcgaaccccugugccuccccggugggngccagnnaugacagaaaagcnacncuggnganaacagagucgucucnggngagagcccanaucgacccngaggnuugcuaccungcugncggcucuucccauccuggcncugcagcaggggccaagggugggggnnuucacccauuaaagnggaacgugagcugggnuuagaccgucgugngacaggucggaugcuaucuaccgganguguuggccgccugagnggaaggcucccccaguacgagaggaacagggagcngcggccucuggucuacngguuguccuacagggcauagccgggcagcuacgcngcagcngauaaggccugaaagcaucuaaggncgaagcggcccccgaaaacaggcggccaccgagggcccgggaagaagaccngguugauggggcggggauguaagcgggaagggaaacngaccnguucagucugcngcucccaacagccngagugcuaccggg <<<<<<.<<<.....<<<<<<<<<<.....<<..<<<<<.<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<....>>><<<<<..>>>>>.<<<<<....>>>>>.>>....<<<<<.....<......>......>>>>>...........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<...<<<...<<<<<<<<<....>>>>>>>>>.....>>>.....<<<<<<<<<....<<<<..<<<<<<<...<<<.....<<<<......>>>>.((......<<<.....))>>>...>>>....>>>>>>>.>>>>..>>>>.>.>>>>.....<<<<<<<........>>>>>>>......<<<<<.((((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>.................>>>>>>>>>>........<<<<<<<<<<....<<......<<<<<<<...<....<<<<<....>>>>>.....>..>>>>>>>...>>.>>>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.....<<<<...<<<<...>>>>...>>>>.<<<<<<....>>>>>>...>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<..<<<.<<<<<<<<<....<<...<<<<.<<<<<<......<.........>...>>>>>>.>>>>..>>.....>>>>>>>>>>>>.....>>>>>>>.>>..<<<<<<<<<....>>>>>>.>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<.........<<<.<<<<<<<<<<......<..<..>..>...>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<<<<....>>>>>>>>..>>....>>>>>><.<<<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<......<<<<<<.......>>>>>><<<<....<<<...<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<<<<.....>>>.>>>>>>....>>...<<<<<........>>>>>))<<<<<<<<.....<<<....>>>...<<<<<<<<<<...<<<<<<<<<..<<<<<<<<<<<<....[>>>>>>....<<<<.<..<<<<<<.....<<<<...>>>>.....>>>>>>...>>>>>.....<<<<<<......>>>>>>>>>>>>...>>>>>>>>>.........>>>>>>>>>>......>>>>>>>>>>>>..>>.....<<......>>...>>>.<<<<.....>>>>..>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<.....>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<....>>>>......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<<<<<......>>>>>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>....>>....<<<<<........>>>>>..<<<<<<<<.<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<<<<<...<<...........<<<<<..<<<......<<<<<.<<<...>>>>>>>>...>>>............>>>>>..>>...>>>>>>>>>>>...<<<<<....>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<<.......>>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.))))))>>>>>>>>>>..........>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>..<<<.......>>>......>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>>>>>>>>>....<<<<<<<<..<<<<..<<<<<<<.................>>>>>>><<<<<...<<<<...<<<<<<<<<<]...>>>>>..>>>>>...>>>>.>>>>>.<<<<.<..<<<<<...........>>>>>...>>>>>>>>>>......>>>>>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<<<<<....<<<<<..<<....>>..>>>>>...>>>>.>>>>>.>>>...>>>>...>>>.>>>>>> ((((((.((((....((((((((((....(((..(((((.(((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))(((((..))))).(((((....))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((..((((((.(((....))).)))))....)))....(.(((((((((....((((.(.((((((...(((...({((((......)))))[[(...).(((....}]])))...)))....))))))).))))..)))).).))))]....(((((((........)))))))....).(((((.[[[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))...........))....))))))))))......(.((((((((((....((......(((((((...(....(((((....))))).....)..)))))))...)).)))))))))).[((((........))))((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((...))))...)))))((((((....))))))...)))))))))))))..((.(...((((.(.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..).))))......).))).((((((....(((((....))))).(((((((...(((.(((((((((...(((...(((..(((((.....(.((.......).))..)))))..)))..)).)...))))))))))))......)))))).)...(((((((((....)))))).)))....(((......)))...(((((((...((([[[...(.((((((.....((.........(((.((((((((((........((()).)....)))))))))))))..........]]]))....))))))))))...)))))))((((((((((....))))))))..))....))))))(.((((((((((......((((((((....))))))))...))))))))))..).....))))))((.....((......((((((.......))))))((((....(((...((..(((((((...((.....)).))))))....[[(((.((...(((((((((.....))).))))))....))...(((((........)))))]]((((((((..(..(((....)))...((((((((((...(((((((((..((((((((((((....{))))))(...((((....((((((.....(((.....))).....))))))....))))....)((((((......))))))))))))...)))))))))(...)....))))))))))..)...)))))))).))).))).....((......))...))).((((.....))))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((.....))))))))))(...).......(((((((((.].((.........))...(((((((....((((....))))......))))))).}((((.(((..(((((((..(((...((((((......))))))...))))))))..)))))(((((.........))))).........(..........((((((.....))))))..).......))))...)).))))))).)..))).)))))))).))))))....))){..(((((.....].})))))..((((((((.(((.((......((((.((((((..(((((.(((((((((.((((((((((.(((.(...........(((((..(((.......((((.((.....))))))....)))............)))))...)).))))))))))))...(((((....)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.(((((....)))))...).((][.[[[))....))))))).(.((((((((((.......)))))))))))(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..)))))))))))...)(((((((...((((..(((((((......(....).....)))))))(((((...((((...((((((((((}...)))))..))))).[.)))).))))).((((....((((.............))))....)))))))).......)))))))..(..(((((((((.......)))))....((((((((((((....(((((..((....))..)))))...))))]))))).)))...))))..)))).)))))) Cryo-EM Structure of T. kodakarensis 70S ribosome; 23S rRNA 6skf BB 125 2.95 RF00001 URS000037D4EC_311400 32555463 0003735 0005840 311400 gguacggcggccauagcggcggggccacacccggucucguuucgaccccggaaguuaagcccgccagcguucccggguguacugcccuccgagagggggcgggaaaccgggaacgccgccggcca <<<.<<<<<<<....<<<<<<<<.....<<<<<<....<<....>>.>>>>..>>....>>>>>>.>>.<<<<<<<......<<<<<.<<....>>>>>>>.....>>>>>>>.>>>>>>>>>>. (((.(((((((....((((((((.....(.((((.............))))....)...)))))).))..((((((.....((((((.((....))))))))....))))))..)))))))))). Cryo-EM Structure of T. kodakarensis 70S ribosome; 5S rRNA 6skg Aa 1463 2.65 RF00177,RF01959,RF01960 URS00021ED912_311400 32555463 0003735 0005840 311400 auuccggnugauccugncggaggccacugcuauggggguccgacuaagccaugcgagucauggggcgcgcgcgcgcaccggcggacggcucaguaacacgucgguaacnuacccucgngagggggauaaccccgggaaacuggngcuaaucccccauaggccugagguacuggaagguccucaggccgaaaggggcaugcccgcccgaggaugngccggcggcngauuagguaguuggugggguaacggcccaccaagccgaagaucgguacgggccaugagagugggagcccggagauggacacugagacacgnguccaggcccuacggggcgnagcaggcgnganaccuccgcaaugcgggcaaccgcgacggngggacccccagugccguggcagccacggcuuuuccggaguguaaaaagcuccgggaauaaggncugngcaaggncgguggnagccgccgngguaanaccggcggcccgagungungccgcuauuauugggccuaaagcguccguagccnggcccguaagucccuggcgaaaucccacggcucaaccguggngcuugcuggggauacugcgggccuugggaccgggagaggccggggguaccccugngguaggngugaaauccuauaaucccagggngaccgccagungngaaggcgcccggnuggaacggguccgacggugagggacgaaggccaggggagcgaaccggauuagauacccggguagucnnggcuguaaaggaugcgngcuaggugucgggcgagcuucgagcucgcccggugccggagggaagccguuaagnccgccgccugnggaguacggccgcaangnugaaacuuaaaggaauuggcgggggagcacuacaagngguggagcgugcgguuuaauungaunnaacgnngggaaccucaccgggggcgacggcaaggccagncugaaggucuugccggcgagaggannugcauggnngnngucagcucguacngugaggcguccacuuaagugugguaacgagcgagacccgcgcccccaguugccaguccuccccgcuggggaggaggcacucuggggngaccgccggcgauaagccggaggaaggagcgggcgacgguaggucaguaugccccgaaacccccgggcuacacgcgngcuacaaugggcgggacaaugggauccgaccccgaaagnggaagggaauccccuaaacccgcccucaguucggaucgcgggnugcaacucgcccgcgugaagcuggaaucccuaguacccgngugucaucaucgcgnggcgaauacgucccugcuccuugcacacacngnccgncanuccacccgagcgggguccgggugaggccuggucucccuucggggaggccgggucgagccugggcuccgugaggggggagaagucguancaagguagccguaggggnnccuacggnungauc ...<<<<<.[.((((>>>>>.<<<<<<<<<..<<<<<<.<<......<<<.<<<..<<<..<<.<<<<<..>>>>>.>>>>>......<<........<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<<....>>>>>>.....>>>>>...<<<<<<<<<.<<......>>>>>>>>>>>.....<<<<..>>>>.>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<............>>>>>.<<<<....>>>>...>>>>>>......<<.<<<....<<<<....>>>>..>>>>>>>.>>>>>>..<<<<<<<<.>>>>>>>>...<<<<<<<<.......>>>>>>>>.....<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<....<<<<<<<<.....>>>>>>>>...>>>>>>>>..>>>>>>>>>...<<<<<<.....<<<<<<<.<..<<<<<<<<<..<<<......>>>.....>>>>>>>>>..>........<<....>>.>>>>>>>....>>>.>>>...>>>...>>>>...<<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>>.........<<<<<<..<<<<<<<<<<<<<<.....>>>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<...<<....<<<.<<<<.....>>>>.>>>..>>...<<.<<<..<<<<<<<<.....<<<<<<.<<....>>...<<<<......>>>>..>>>>>>....<<<<<.<<<<<<<..<<<..<<<<<<<<...>>>>>>>>>>>...>>>>>>>.....<<<<<.....>>>>>........>>>>>.....>>.>>>...>>>>>>>>....>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>.....<<<<<<<.......>>>>>>>.......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<.<<<<<<<<<..<<<<<<<<<<<<<<..>>>>>>>>>>>>>>..>>>>>>>>.>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... ...((((..[.[[[..)))).(((((((((..((((((.(((.....(((.(((..(((..((.(((((()))))).)))))......(((.......(((((((..((...(((((((.(((((....((((((....)))))).....)))))...(((((((((.((......))))))))))).....((((..)))).)))))))..))))))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((((((.))))))))....(((((((.......)))))))......((((([[....(.((((.....((..]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((.....(((((((.....)))))))....))))))))..)))))))))..(((((((.....(((((((((..((((((((...((........))......))))))))..)).......((....)).)))))))....))).)))..))))...))))...(((((((...((...((((.........))))...))))))))).....{...((((((..((((((((((((((.....))))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..((((((((((......((........))..........(((((((...((....(((.((((.....)))).)))..))...((.(((...(.((((((....((((((.(......)...((((......))))..))))))....(((((.(((((((..(((..((((((((...)))))))))))...)))))))..(..(((((.....))))).....)..)))))....))).)))....).)))))....)))))))...)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..)))))......(((((((.......))))))).......))...)))))))))).))..(.(..((.(.((((.(((..((.((((((((((..((((((((((((((..))))))))))))))..)))))))).))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Cryo-EM Structure of T. kodakarensis 70S ribosome in TkNat10 deleted strain; 16S ribosomal RNA 6skg BA 2934 2.65 RF02540,RF00002 URS00021ED9BB_311400 32555463 0003735 0005840 311400 cccgguggcaacuaagccgccugguggauggcucggcucggggcgncgacgaangnnguggcaagcugcgauaagccccggngaggcgcaggcagccgucgaaccggggaugcccgaaugggaccucccgcggcuugccgcacucccagucgggagggggaacgcggggaauugaaacaucuuaguacccgcaggaaaagaaancaaaagcgaugccguuaguaggggcgaccgaaagcggcacagggcaaacugaaccccgggccgaaagguucgngggaugugguguuguagggcccgcggaggagcccugggggcgaagccgaagucngcuggaacgcggcgccggagagngugaaagccccguaggcguaagcccccgagcuccugcggugucccugaguaccgucggucggauauccggcgggaagcugggaggcancggcucccaacccuaaauacgucccgagaccgauagcgaacuaguaccgugngngaaagcugaaaagcaccccgggaggggggugaaaagagccugaaaccaggcggcgauaggagggugcggcccgaaangguugacccuccccgaaggaaacacgggcgaccguggaguacgaggggaggugaccgggguugcaccguccgncuuggaucacggngcanggaguucacccgagcggcgagguuaagggggucaaccccgaagccgcagggaaaccgacagguccgcagcccguagggcgagggacggggugugaaagcgcccggagucgcucgggugagacccnaagccggucgaucuagcccggggcagggngaanucccucaacagagggnuggaggcccgcuaggggugnugncgngcanuucgcucccgugaccccgggcuaggggugaaangccaaucgaggccggcgaungcugguucccgccgaauuaucccccaggauagcccggccggagguaggcagugggguagagcacugauuggggguuuagggggcgaaagccuccggcucccugucaaacuccgaacccacugccgccguagauggccggaguaggggggcgguguaagccgucacccgagaggggaacaacccagaccgggguuaaggccccaaagugccggcuaagnguuacuccaaagggugucccuggccuuagacagcggcccgucgaggucaggggccccgaaaauggacggggcuuaagccggccgccgagaccccggcgcacggaccgauugguccgugaucggguaggcnggcgugccgauggggnggaagccgggccgugagguccgguggacccgucgguauugcggauccugccgggagnagcagcauagccgggugagaaucccggccgccguaggggccaggguuccacggcaauguucgucagccguggguuagncgguccuaacccgacccguaacucggcnucggggaaagggaaacngguuuauauucccguaccgcggugguaggugcggcaacgcaagcccgaggggugacgccucgggguaggcggaccgguccacaaggccggcuaagcguauaagcccggggagugccguaauggcgagaaccgggugaaagcgcgaauggccucccguaagggggguuccgccgaucccuggggcccgugaaaagccccucgggaacgauccaccgcgaccguaccgagaaccgacacuggngccccugggngagaagccuaaggcgugucgggggaaacccagccgagggaacunggcaaauuggccccguaacuucgggagaaggggngccugcggguguguaacccgcaggucgcagugacuaggngggcccgacuguuuaguaaaaacacaggucccagcuagcccgaaaggguuuguacugggnccnacgccugcncagngccgguaugugaagcccggguacaancgggugaagcaccgnuaaacngcggggguaacuauaacccucuuaagguagngaaauucnuugucgguuaaaugncgacnugcaugaauggcguancgagguccccacuguncccggcuggggcccggngaaaccucugccaggcgcauaugccugggaccuccggugggaanngaagaccccauggagcuuuacugcagccugccguugccguacggcggggggugcgcagcguaggcgggaggcgucgaagcccgcccuccggggcggguggagccgcccaugagacaccgcccacccucugccguacggcuaacccgcggaagcggggacngcgguaggugggcaguuuggcugnggcggcacacccucgaaaagguaucnagggugcccnaaggucggcucaggcgggucaggaauccgccguagagngcaagggcaaaagccggccugacuggacccguaacagangcngguccagccgcgaaagcguggccuagcgaaccccugugccuccccggugggngccagnnaugacagaaaagcnacncuggnganaacagagucgucucgggcgagagcccanaucgaccccgaggnuugcuaccungcugucggcucuucccauccuggcccugcagcagngnccaagggugggggnguucacccauuaaagnggaacgugagcugggnuuagaccgucgugagacaggucggaugcuaucuaccgganguguuggccgccugagnggaaggcucccccaguacgagaggaacagggagccgcggccucuggucuaccgguuguccuacagggcauagccgggcagcuacgccgcagccgauaaggccugaaagcaucuaaggccgaagcngcccccgaaaacaggcggccaccgngggcccgggaagaagacccgguugauggggnggggauguaagcgggaagggaaaccgacccguucagucugccgcucccaacagcccgagugcuaccggg <<<<<<<<<<.....<<<<<<<<<<....[<<..<<<<<<<.[<<<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<....>>><<<<<..>>>>>.<<<<<....>>>>>.>>....<<<<<.....<<....>>......>>>>>...........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<...<<<...<<<<<<<<<....>>>>>>>>>.....>>>.....<<<<.<<<<..<<<<<<..<<<<<<<...<<<.....<<<<......>>>>.((......<<<.....))>>>...>>>....>>>>>>>.>>>>>>>>>>...>>>>.....<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......>>.]>>>>>.>>...............<<....>>....>>.........<<<<....>>>>............]....>>>>>>>>>>........<<<<<<<<<<....<<......<<<<<<<...<....<<<<<....>>>>>.....>..>>>>>>>...>>.>>>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.....<<<<...<<<<...>>>>...>>>>.<<<<<<....>>>>>>...>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<..<<<.<<<<<<<<<...<<<...<<<<.<<<<<<....<<<<.......>>>>.>>>>>>.>>>>..>>.>...>>>>>>>>>>>>.....>>>>>>>.>>..<<<<<<<<<....>>>>>>.>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<.........<<<.<<<<<<<<<<.........<..>......>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<<<<....>>>>>>>>..>>....>>>>>><.<<<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<......<<<<<<.......>>>>>><<<<....<<<...<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<<<<.....>>>.>>>>>>....>>...<<<<<........>>>>>))<<<<<<<<.....<<<....>>>...<<<<<<<<<<...<<<<<<<<<..<<<<<<<<<<<<.....>>>>>>....<<<<.<..<<<<<<.....<<<<...>>>>.....>>>>>>...>>>>>.....<<<<<<......>>>>>>>>>>>>...>>>>>>>>>.........>>>>>>>>>>......>>>>>>>>>>>>..>>.....<<......>>...>>>.<<<<.....>>>>..>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<<<<<.....>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<....>>>>......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<<<<<......>>>>>>...>>>>>>>>..>>>>><<<..............>>>.......<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>....>>....<<<<<........>>>>>..<<<<<<<<.<<<.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<<.<<<<<<<<<<<.<<<<<..........<<<<<..<<<......<<<<<.<<.....>>>>>>>...>>>............>>>>>.>>>>>.>>>>>>>>>>>...<<<<<....>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<<.......>>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>..<<<.......>>>......>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..>>>>>>>>>>>....<<<<<<<<..<<<<..<<<<<<<.................>>>>>>><<<<<...<<<<...<<<<<<<<<<....>>>>>..>>>>>...>>>>.>>>>>.<<<<.<..<<<<<...........>>>>>...>>>>>>>>>>......>>>>>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<<<<<....<<<<<..<<....>>..>>>>>...>>>>.>>>>>.>>>...>>>>...>>>>>>>>>> ((((((((((.....(((((((((.....(((..(((((((.(((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))(((((..))))).(((((....))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((..((((((((((....)))))))))....)))....(.(((((((((..((((((.(.((((((...(((...({((((......)))))[[(...).(((....}]])))...)))....))))))).)))))))))).).))))]....(((((((........)))))))....).(((((.[[[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))...........)).....)))))))))......(.((((((((((....((......(((((((...(....(((((....))))).....)..)))))))...)).)))))))))).[((((........))))((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((...))))...)))))((((((....))))))...)))))))))))))..((.(...((((.(.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.(..........))).)))..).))))))))).(.(((.....)))...)..).))))......).))).((((((....(((((....)))))((((((((...(((.(((((((((...(((...(((..((((((....(..(.......)..).))))))..)))..)).)...))))))))))))......)))))).))..(((((((((....)))))).)))....(((......)))...(((((((...((([[[...(.((((((.....((.........(((.((((((((((..........().......)))))))))))))..........]]]))....))))))))))...)))))))((((((((((....))))))))..))....))))))((((((((((((......((((((((....))))))))...)))))))))).)).....))))))((.....((......((((((.......))))))((((....(((...((..(((((((...((.....)).))))))....[[((((((...(((((((((.....))).))))))....))...(((((........)))))]]((((((((..(..(((....)))...((((((((((...(((((((((..((((((((((((....{))))))(...((((....((((((.....(((.....))).....))))))....))))....)((((((......))))))))))))...)))))))))(...)....))))))))))..)...)))))))))))).))).....((......))...))).((((.....))))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((.....))))))))))(...).......(((((((((.].((.........))...(((((((....((((....))))......))))))).}((((.(((..((((((((..((...((((((......))))))...))))))))..)))))(((((..........)))))........(..........((((((.....))))))..).......))))...)).))))))).)..))).)))))))).))))))....))){..(((((.....].})))))..((((((((.(((.((......((((.((((((..(((((.(((((((((.((((((((((..((.(.(.........(((((..(((......(.(((.((.....))))).)...)))............))))))..)).).))))))))))...(((((....)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....))))))).(.((((((((((.......)))))))))))(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..)))))))))))....(((((((...((((..(((((((......(....).....)))))))(((((...((((...((((((((((}...)))))..))))).[.)))).))))).((((....((((.............))))....)))))))).......)))))))..(..(((((((((.......)))))....((((((((((((....(((((..((....))..)))))...))))]))))).)))...))))..))))))))))) Cryo-EM Structure of T. kodakarensis 70S ribosome in TkNat10 deleted strain; 23S ribosomal RNA 6skg BB 125 2.65 RF00001 URS000037D4EC_311400 32555463 0003735 0005840 311400 gguacggcggccauagcggcggggccacacccggucucguuucgaccccggaaguuaagcccgccagcguucccggguguacugcccuccgagagggggcgggaaaccgggaacgccgccggcca <<<.<<<<<<<....<<<<<<<<.....<<<<<<.............>>>>..>>....>>>>>>.>>.<<<<<<<.....<<<<<<.<<....>>>>>>>>....>>>>>>>.>>>>>>>>>>. .(..(((((((....((((((((.....((((((...(.....)...))))..))....)))))).))..((((((.....((((((.((....))))))))....))))))..))))))).).. Cryo-EM Structure of T. kodakarensis 70S ribosome in TkNat10 deleted strain; 5S ribosomal RNA 6snt 2 1771 2.8 RF01960,RF01959,RF00177 URS00005F2C2D_4932 32203490 0003735 0005840 4932 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugagcuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauu ...<<<<<.{.((((>>>>><<<<.<<<<<<...<.<...<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<..<<..<<....<<<..................<<....<<.<<<.....>>>.>>.....>>.........<<<<<..<<....>>..>>>>><.<.<<<<<<......((((.((.<<<....>>>..............>>>>>>.>...>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>..>>>..>....>.>.....<<<<<<<<<<<<<....>>>>>>>>>>.>>>......<<..<...........>..>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>>>>>.........<<<[[.....<.<<...<<<.<<....<<<<<<.<<<<<...........>.>>>>.>>>>>>.....<<<<<....................>>>>>....<<<<<.<<.......<<...<.......>..<<<<...>>>>....>>......>>.>>..>>>.........<<<..<<<<<<<<.....)).)))).>>>>>>>>.>>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..]]>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..)))).}<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<<<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>...>.>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>......<....<<<<<<..........>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<.<<<<.<<<<....>>>>.>>>>.>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>........ ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[[.[[[.(((....))).....(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(((((((.(.(((....))).).)))).)))....(.(((.(...........)).))......)..((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((................))).))))))....((((((....................))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(....(.((.(((.....]].]]]].))).)).)...).....))...(((.(((.((...((((..((..((((((.(...((........))......).))))))..)).......((....))...))))..)).)))..))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].].((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((.(..(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..))))).)..))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....((((((((.......))))))))......))...)))))))))).)...(.(..((.(..((((.((..(.((((((((.(((..(.((..(...((((((..((((.((((....)))).))))..))))))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>....... Yeast 80S ribosome stalled on SDD1 mRNA.; Saccharomyces cerevisiae S288C 18S ribosomal RNA (RDN18-1), rRNA 6snt 4 121 2.8 RF00001 URS000055688D_4932 32203490 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Yeast 80S ribosome stalled on SDD1 mRNA.; 5S rRNA 6snt 3 158 2.8 RF00002 URS00001BF64E_4932 32203490 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Yeast 80S ribosome stalled on SDD1 mRNA.; 5.8S rRNA 6snt 1 3184 2.8 RF02540,RF02543 URS000061F377_4932 32203490 0003735 0005840 4932 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaugguguuuuguauuucacuggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauagagggcuaccuuuauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu .........................<<<<<.....<<....>>......>>>>>...........<<....>>..<<<<<......<<.....>>.....>>>>>..<<<...<.......<<.<<<<<<...>>>>>>.>>.......>.....<<<<<<<.<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<.........................<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<....<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>..>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<.<.....>..>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<..<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..[[[..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>....>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<.<<<<<<<<<<<....>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.....<<.....<<<<....>>>>.....>>..>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<..<<<<<<<<<<<<<<<<<....>>>>>>>.>>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))......<<<<<<<..<<<<.))))))>>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>..>>........<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>.....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<....<<<<<<<<<<]]].>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<.<..<<<<<......>>>>>..>>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((......(..............)..(((((((((((((((((((((((.......(((((((......((((.(....).)))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((((((((((....((.(((((((.....(((....(((..(.((((...((((((.....)))))).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((.(((...((.........))...))).........((......))...)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....))).........((...(.....)....)).....))....))...(((((........)))))]]((((..(((.(((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....)))...))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((....)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((((((((((((....))))))).))))))))))...(((((.....((((..((((........))))...........>...((((((....))))))..))))..))))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(((.((..)..).)))..)))))...)))....)))).)))))).))))).. Yeast 80S ribosome stalled on SDD1 mRNA.; Saccharomyces cerevisiae S288C 25S ribosomal RNA (RDN25-1), rRNA 6snt 5 21 2.8 32203490 4932 aauccuggauggaacgacgaa ..................... ..................... Yeast 80S ribosome stalled on SDD1 mRNA.; mRNA 6snt 6 76 2.8 RF00005 URS000080E1EA_4932 32203490 0030533 0006412 4932 uuccucguggcccaauggucacggcgucuggcuicgaaccagaagauuccagguucaaguccuggcggggaagcca <<<<<<<..<<<..........>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..(((.....[....))).(((((.......))))).....(((((..]....)))))))))))).... Yeast 80S ribosome stalled on SDD1 mRNA.; tRNA 6spb A 2885 2.82 RF02540,RF02541 URS000197CF82_287 31611393 0003735 0005840 287 gucaagugaagaagcgcauacgguggaugccuuggcagucagaggcgaugaaagacgugguagccugcgaaaagcuucggggagucggcaaacagacuuugauccggagaucucugaaugggggaacccaccuaggauaaccuagguaucuuguacugaauccauaggugcaagaggcgaaccaggggaacugaaacaucuaaguacccugaggaaaagaaaucaaccgagauucccuuaguaguggcgagcgaacggggauuagcccuuaagcuucauugauuuuagcggaacgcucuggaaagugcggccauagugggugauagccccguacgcgaaaggaucuuugaagugaaaucaaguaggacggagcacgagaaacuuugucugaacauggggggaccauccuccaaggcuaaauacuacugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggagaggggagugaaauagaaccugaaaccguaugcguacaagcagugggagccuacuuguuaggugacugcguaccuuuuguauaaugggucagcgacuuauauucaguggcaagcuuaaccguauaggguaggcguagcgaaagcgagucuuaauagggcguuuagucgcuggguauagacccgaaaccgggcgaucuauccaugagcagguugaagguuagguaacacugacuggaggaccgaacccacucccguugaaaagguaggggaugacuuguggaucggagugaaaggcuaaucaagcucggagauagcugguucuccucgaaagcuauuuagguagcgccucauguaucacucugggggguagagcacuguuucggcuagggggucaucccgacuuaccaaaccgaugcaaacuccgaauacccagaagugccgagcaugggagacacacggcgggugcuaacguccgucgugaaaagggaaacaacccagaccgccagcuaaggucccaaaguugugguuaagugguaaacgaugugggaaggcuuagacagcuaggagguuggcuuagaagcagccacccuuuaaagaaagcguaauagcucacuagucgagucggccugcgcggaagauguaacggggcucaaaccacacaccgaagcugcgggugucacguaagugacgcgguagaggagcguucuguaagccugugaaggugaguugagaagcuugcuggagguaucagaagugcgaaugcugacaugaguaacgacaaugggugugaaaaacacccacgccgaaagaccaaggguuccugcgcaacguuaaucgacgcaggguuagucgguuccuaaggcgaggcugaaaagcguagucgaugggaaacagguuaauauuccuguacuucugguuacugcgauggagggacggagaaggcuaggccagcuuggcguugguuguccaaguuuaaggugguaggcugaaaucuuagguaaauccgggguuucaaggccgagagcugaugacgagucgucuagaugacgaagugguugaugccaugcuuccaagaaaagcuucuaagcuucagguaaccaggaaccguaccccaaaccgacacagguggucggguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggcaccguaacuucgggagaaggugcgccggcuagggugaaggauuuacuccguaagcucuggcuggucgaagauaccaggccgcugcgacuguuuauuaaaaacacagcacucugcaaacacgaaaguggacguauagggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaacgauggcggcgcugucuccacccgagacucagugaaauugaaaucgcugugaagaugcaguguauccgcggcuagacggaaagaccccgugaaccuuuacuguagcuuugcacuggacuuugagccugcuuguguaggauaggugggaggcuuugaagcguggacgccaguucgcguggagccauccuugaaauaccacccuggcaugcuugagguucuaacucugguccguaauccggaucgaggacaguguauggugggcaguuugacuggggcggucuccuccuaaagaguaacggaggaguacgaaggugcgcucagaccggucggaaaucggucgcagaguauaaaggcaaaagcgcgcuugacugcgagacagacacgucgagcagguacgaaaguaggucuuagugauccggugguucuguauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaagccggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccguggacguuugagauuugagaggggcugcuccuaguacgagaggaccggaguggacgaaccucugguguuccgguugucacgccaguggcauugccggguagcuauguucggaaaagauaaccgcugaaagcaucuaagcgggaaacuugccucaagaugagaucucacugggaacuugauuccccugaagggccgucgaagacuacgacguugauaggcuggguguguaagcguugugaggcguugagcuaaccaguacuaauggcccgugaggcuugacc 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(((((((......((((((((((.....(((..(((((((((((((......((((((.[[.[[[.))).....((((((...(((]]]..]].)))......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...(((.....((((((..((((((.(((...(((.(......).)))[[(...).(((.....]])))...)))...))))))..))))))...........((((((((..[......)))))))).......((((].[[[[))))...)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((.......))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.((.((.......<)).)))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..(((((((((.....(((....((.(((..(.(((...(.....)..)..))..).))).))...)).).....)))))).)))....))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(......(..((((....(......{.....(................................................).........)...)))).)............]]].)....))))))))))...)))))))((((((......))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((..((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((((((.(.(...((((....((((..(((..(((((((((((....{{{...))))))(...(((....(((.((((((((.((.....))))))))))...)))..[.)))....)(..(((.((())).)))...))))))...)))...))))(..).....))))...)......)))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((...(((....])))....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))((((...........))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....))....(((((.....]..)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((.((.((.((((........[{..(((.....(........(..(.(......).)..).....)....]......}...)))...))).))).)).))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((.............)))...).((][..[[))....)))))))...((((..(((...{..)))..)))).(.(....).).))]]..].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.))..)))))))))))[...(((((((...((((..((((((......(....).....)))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))..).)))))))). Pseudomonas aeruginosa 50s ribosome from a clinical isolate with a mutation in uL6; 23S ribosomal RNA 6spb B 117 2.82 RF00001 URS000197CF68_287 31611393 0003735 0005840 287 gcuugacgaucauagagcguuggaaccaccugaucccuucccgaacucagaagugaaacgacgcaucgccgaugguaguguggggucuccccaugugagaguaggucaucgucaagc <<<<<<<<<<....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>><<<.......<<<<<<<<...>>>>>>>>.......>>>.>>>>>>>>>> (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((...)))))))).......)))..))))))))) Pseudomonas aeruginosa 50s ribosome from a clinical isolate with a mutation in uL6; 5S rRNA 6spd A 2851 3.28 RF02540,RF02541 URS000197CF6F_287 31611393 0003735 0005840 287 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Pseudomonas aeruginosa 50s ribosome from a clinical isolate; 23S ribosomal RNA 6spd B 116 3.28 RF00001 URS000197CF86_287 31611393 0003735 0005840 287 uugacgaucauagagcguuggaaccaccugaucccuucccgaacucagaagugaaacgacgcaucgccgaugguaguguggggucuccccaugugagaguaggucaucgucaagcu .<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<...>>>>>>>>.......>>>.>>>>>>>.... .((((((.....((((((((....(((((((.............))))..)))...)))))).))(((.......((((((((...)))))))).......)))..)))))).... Pseudomonas aeruginosa 50s ribosome from a clinical isolate; 5S ribosomal RNA 6spf A 2885 2.89 RF02540,RF02541 URS000197CF82_287 31611393 0003735 0005840 287 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Pseudomonas aeruginosa 70s ribosome from an aminoglycoside resistant clinical isolate; Pseudomonas aeruginosa strain PAO1 23S ribosomal RNA 6spf B 117 2.89 RF00001 URS000197CF68_287 31611393 0003735 0005840 287 gcuugacgaucauagagcguuggaaccaccugaucccuucccgaacucagaagugaaacgacgcaucgccgaugguaguguggggucuccccaugugagaguaggucaucgucaagc <<<<<<<<<<....<<<<<<<.....<<<<<<...............>>>..>>>....>>>>>.>><<<.......<<<<<<<<...>>>>>>>>.......>>>.>>>>>>>>>> (((((((((.....(....(((....(.(((((...(.....)...))))..).)...))).....)..(.......((((((((...)))))))).......)....))))))))) Pseudomonas aeruginosa 70s ribosome from an aminoglycoside resistant clinical isolate; 5S rRNA 6spf a 1390 2.89 RF00177,RF01959,RF01960 URS000197CF71_287 31611393 0003735 0005840 287 gaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgagcggaugaagggagcuugcuccuggauucagcggcagacgggugaguaaugccuaggaaucugccugguagugggggauaacguccggaaacgggcgcuaauaccgcauacguccugagggagaaagugggggaucuucggaccucacgcuaucagaugagccuaggucggauuagcuaguuggugggguaaaggccuaccaaggcgacgauccguaacuggucugagaggaugaucagucacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauuggacaaugggcgaaagccugauccagccaugccgcgugucuuuaaguugggaggaagggcaguaaguuaauaccuugcuguuuugacguuaccaacagaauaagcaccggcuaacuucgugccagcagccgcgguaauacgaagggugcaagcguuaaucggaauuacugggcguaaagcgcgcguaggugguucagcaaguuggaugugaaauccccgggcucaaccugggaacugcauccaaaacuacugagcuagaguacgguagagggugguggaauuuccuggaaggaacaccaguggcgaaggcgaccaccuggacugauacugacacugaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuagccguugggauccuugagaucuuaguggcgcagcuaacgcgauaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaaugcugagaacuuuccagagauggauuggugccuucgggaacucagacacaggugcugcauggccagcucgugucgugagauguuggguuaagucccguaacgagcgcaaccuccuuaguuaccagcaccucgggugggcacucuaaggagacugccggugacaaaccggaggaaggugucaagucaucauggcccuuacggccagggcuacacacgugcuacaauggucgguacaaaggguugccaagccgcgagguggagcuaaucccauaaaaccgaucguaguccggaucgcagucugcaacucgacugcgugaagucggaaucgcuaguaaucgugaaucagaaugucacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcuccagaaguagcuagucuaaccgcaagggggacgguuaccacggagugauucaugacuggggugaagucguaacaagguagccguaggggaaccugcggcuggau ...<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<<...<..<<<..>>>..>..>.>>.>>>>>......<<.......<<<<<<<..<<...<<<<<<<<<.<<.....<<<<<<....>>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>>>>>>>>>..>>.>>>>>>><<<....<<<...<<<<<<<.......>>>>>>>.>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..........<<<<<......<<<..<..<<........>>..>..>>>.......>>>>>.......<<<<<((.....<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<..<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>.>>>>>>...<<<<<<<....<<<<<<<.....<<<<.>>>>............<<....>>.>>>>>>>...>>>.>>>>...>>>...>>>>....<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<.....>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<....<<<.........<.......>.......<......>....>>>.........<..........<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>....................<<.......>>..................<<<<<.....>>>>>.....................>............................................................................................................................................................................>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.... ...((((..[.[[[..)))).((((.(..((...((((((((....(((.(((..(((......(....(.((......).))....)....)))......(((......((((((...((...(.(.(((((.((.....((((((....))))))......)).)......((....)).....((.(((....(...).)).))))))).).)..))..))))))(((....((...((((((((.......)))))))).))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((.....(((....)))...)))).)).)))))...(.).....(((((......(((.((..(..........)..).)))).......))))).......((((([.......(((.....((...])).......)).).)))))..))..)))))..........((([[...(.((((...(((.((((((..((.(((((((......((((((.....))))))....)))))))...)).))))))..((((((((....(.((((((......((.))......).......((....)).))))).)...))).))))..))))...))))....(.((((....(...(((...........)))...).)))).)......{...((((((...(((.((((((.......)))))).)))....((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.((((((..((...(..(.(......(........)........(....)...).)...)......((......(...(((((((((....)))...(((......)))...))))))........(........(...(.......).).........).......(..((.....).).)..................)..).)..............................................(...(................).....).............................(............).....................................................))....))))))))).))....(..((.(.((((.(((..((((((((((((....((((((.(((...((....))..)))))))))...))))))))))))..))).))))..).))...).....(((.(((((....))))).)))}... Pseudomonas aeruginosa 70s ribosome from an aminoglycoside resistant clinical isolate; 16S rRNA 6spg a 1526 3.34 RF00177,RF01959,RF01960 URS000197CF85_287 31611393 0003735 0005840 287 aacugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgagcggauaaagggagcuugcuccuggauucagcggcggacgggugaguaaugccuaggaaucugccugguagugggggauaacguccggaaacgggcgcuaauaccgcauacguccugagggagaaagugggggaucuucggaccucacgcuaucagaugagccuaggucggauuagcuaguuggugggguaaaggccuaccaaggcgacgauccguaacuggucugagaggaugaucagucacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauuggacaaugggcgaaagccugauccagccaugccgcgugugugaagaaggucuucggauuguaaagcacuuuaaguugggaggaagggcaguaaguuaauaccuugcuguuuugacguuaccaacagaauaagcaccggcuaacuucgugccagcagccgcgguaauacgaagggugcaagcguuaaucggaauuacugggcguaaagcgcgcguaggugguucagcaaguuggaugugaaauccccgggcucaaccugggaacugcauccaaaacuacugagcuagaguacgguagagggugguggaauuuccuguguagcggugaaaugcguagauauaggaaggaacaccaguggcgaaggcgaccaccuggacugauacugacacugaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuagccguugggauccuugagaucuuaguggcgcagcuaacgcgauaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccuggccuugacaugcugagaacuuuccagagauggauuggugccuucgggaacucagacacaggugcugcauggcugucgucagcucgugucgugagauguuggguuaagucccguaacgagcgcaacccuuguccuuaguuaccagcaccucgggugggcacucuaaggagacugccggugacaaaccggaggaagguggggaugacgucaagucaucauggcccuuacggccagggcuacacacgugcuacaauggucgguacaaaggguugccaagccgcgagguggagcuaaucccauaaaaccgaucguaguccggaucgcagucugcaacucgacugcgugaagucggaaucgcuaguaaucgugaaucagaaugucacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcuccagaaguagcuagucuaaccgcaagggggacgguuaccacggagugauucaugacuggggugaagucguaacaagguagccguaggggaaccugcggcuggauc .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<....<.<<<<..>>>>.>....>>.>>>>>......<<.......<<<<<<<..<<...<<<<<<<<<.<<.....<<<<<<....>>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>>>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>...<.<<<<<......<<<<<<<<<<.......>>>>>>>>>>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<..<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>.>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<<..<<<......>>>.....>>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<.....>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<......<<<....>>>.......<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((....((((((..))))))....)).)))))......(((......(((((((..((...(((((((((.((.....((((((....))))))......)).).....(((....)))....((((((..((....))))))))))))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((.....(((....)))...)))).)).))))))..((((......((((....)))).....))))...(.(((((...(..((((((.(((.......))).))))))...)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.((((((..((((((((((......((((((.....))))))....))))))))..)).))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((..((((.....))))..))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..(((((..(((......((........))..........(((((((..(...(((((((..(...(((....)))...)...((....))..))))).))).((.(((...((((((.(....((((((((......))...(((......)))...)))))).....((((.(((((.(...((..(((.....)))))....).))))).....(((((.....)))))........)))).....).).)))...)).)))))....)))))))...)).)..))))).(...((((((......(((..((...(.(....).)...))....)))......))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Pseudomonas aeruginosa 70s ribosome from a clinical isolate; 16S ribosomal RNA 6spg A 2883 3.34 RF02540,RF02541 URS000197CF82_287 31611393 0003735 0005840 287 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Pseudomonas aeruginosa 70s ribosome from a clinical isolate; 23S ribosomal RNA 6spg B 117 3.34 RF00001 URS000197CF68_287 31611393 0003735 0005840 287 gcuugacgaucauagagcguuggaaccaccugaucccuucccgaacucagaagugaaacgacgcaucgccgaugguaguguggggucuccccaugugagaguaggucaucgucaagc <<<<<<<<<<....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>><<<.......<<<<<<<<...>>>>>>>>.......>>>.>>>>>>>>>> (((((((((.....((((((((....(((((((.............))))..)))...)))))).))(((.......((((((((...)))))))).......)))..))))))))) Pseudomonas aeruginosa 70s ribosome from a clinical isolate; 5S ribosomal RNA 6sv4 BQ 3127 3.3 RF02540,RF02543 URS000061F377_4932 32203490 0003735 0005840 4932 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........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<.<<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<......<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<......>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<......<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>....>>>>>>.>>>>..>>>>>>><<<<<<<<<......>>>>>>>>>....>>>>>><..<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>...>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<....>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<<<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>.>.>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<.<<<<<<<<<<<..>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{.[[[..<<<<<.<<<<<<<<..<<<<<<<...>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]...}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>..>>........<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>.....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<...<<<<<<<<<<<}}}.>>>>>..>>>>>>..>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>....<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<.<..<<<<<......>>>>>..>>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((.(((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))).....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.(((((......(((((((((((((((((((((((.......(((((((......((((((....)))))).......))))))).....))))).))))))))))........(((....)))....)))))))).....))))).))))).[((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....((...(.((((...(.((((.....)))).).)))).)...))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.......(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((......)))))))))....))))))((((((((((.((......((((.((((....))))))))...)))))))))).)).....))))))((.....((.....((((((.......))))))((((.....((((..((.([((((((...((.....)).)))))))...[[(((.((...((....(((....))).........(((....)).)....))....))...(((((........)))))]]((((..(((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).))).])).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((..)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..((((((.....))))))....((((.....((((..(((.(......).)))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.............))))...)))).))))....))))))))....((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(((.((..)..).)))..)))))...)))....)))).)))))).))))).. The cryo-EM structure of SDD1-stalled collided trisome.; 25S rRNA 6sv4 BR 121 3.3 RF00001 URS000055688D_4932 32203490 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......((((...((....))..)))).....))))))))))))))). The cryo-EM structure of SDD1-stalled collided trisome.; 5S rRNA 6sv4 BS 157 3.3 RF00002 URS00004A45D3_4932 32203490 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>.................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....))))))))).................... The cryo-EM structure of SDD1-stalled collided trisome.; 5.8S rRNA 6sv4 2 1758 3.3 RF01960,RF01959,RF00177 URS00005F2C2D_4932 32203490 0003735 0005840 4932 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...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[..................<.....<<.<<<.....>>>.>>......>.........<<<<<..<<....>>..>>>>>[...((((((......<<<<<<<<<<<....>>>..............)))))).....]...<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>...<<....>>.....]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<<<<<..<......>..>>>>>>.>>>......<<..<...........>..>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..))))))]]]].........[[[{{.......{{...[[[.{{....<<<<<<.<<<<<....<..>....>>>>>.>>>>>>.....<<<<<...........<.......>...........>>>>>....<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[[..(((((((.....>>>>>>>>..))))))).]]].....}}....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<<<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>...>.>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>......<....<<<<<<..........>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<.....>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((....[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[[[[[[[(((....))).....(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....((..(.(((...(....)...))).)...))......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.((((.....(()).....)))).)))))).....(((((...............................)))))....(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(....(.((.(((....]]]]]]]].))).)).)...).....))...(((.(((..(...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)..)))..))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]]..(((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((........((.(((........))).))......)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((..(((((....)))))....)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...(((((...)))))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>........ The cryo-EM structure of SDD1-stalled collided trisome.; 18S rRNA 6sv4 n 76 3.3 RF00005 URS0000E60BDA_4932 32203490 0030533 0006412 4932 uuccucguggcccaauggucacggcgucuggcuacgaaccagaagauuccagguucaaguccuggcggggaagcca <<<<<<<..<<<..........>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..(((.....[....))).(((((.......))))).....(((((..]....)))))))))))).... The cryo-EM structure of SDD1-stalled collided trisome.; tRNA (P/P) 6sv4 2b 1758 3.3 RF01960,RF01959,RF00177 URS00005F2C2D_4932 32203490 0003735 0005840 4932 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...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[..................<.....<<.<<<.....>>>.>>......>.........<<<<<..<<....>>..>>>>>[...((((((......<<<<<<<<<<<....>>>..............)))))).....]...<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<<<<<<.<......>.>>>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.{{.....<<<<<.<<<<<....<..>....>>>>>.>>>>>.....<<<<<<...............................>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[[..((((((((....>>>>>>>>.)))))))).]]].....}}....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<<<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>...>.>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>......<....<<<<<<..........>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<...>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[[[[[[[(((....))).....(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....((..(.(((...(....)...))).)...))......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..)))))))))).........((({{...(.(.((...(((.((.....(((((.(.((......()......).)).))))).....((((((............(.....)............))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(....(.((.(((....]]]]]]]].))).)).)...).....))...(((..((..(...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)..))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...)).....))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((........((.(((........))).))......)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((..(((((....)))))....)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...(((((...)))))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>........ The cryo-EM structure of SDD1-stalled collided trisome.; 18S rRNA 6sv4 YQ 3127 3.3 RF02540,RF02543 URS000061F377_4932 32203490 0003735 0005840 4932 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........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((.(((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))).....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((......((((((....)))))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).<((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))..).))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...(.((((.....)))).).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.......(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((......)))))))))....))))))((((((((((.((......((((.((((....))))))))...)))))))))).)).....))))))((.....((.....((((((.......))))))((((.....((((..((..(((((((...((.....)).))))))....[[(((.((...((....(((....)))........((((....))))....))....))...(((((........)))))]]((((..(((((.(...((((....)))...(.[[((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....).))..))).)))).))).))).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.((((((((((.(.)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.....((.....((((....)))).....))..))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.((((((((..((.(((.....))).))....((((.....((((..(((.(......).)))..........]]...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(..(((((...((.......))...)))))....)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.............))))...)))).))))....))))))))....((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. The cryo-EM structure of SDD1-stalled collided trisome.; 25S rRNA 6sv4 YR 121 3.3 RF00001 URS000055688D_4932 32203490 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......((((...((....))..)))).....))))))))))))))). The cryo-EM structure of SDD1-stalled collided trisome.; 5S rRNA 6sv4 YS 157 3.3 RF00002 URS00004A45D3_4932 32203490 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>.................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....))))))))).................... The cryo-EM structure of SDD1-stalled collided trisome.; 5.8S rRNA 6sv4 nb 76 3.3 RF00005 URS00008FED3A_4932 32203490 0030533 0006412 4932 gcccggauagcucagucgguagagcaggggauuaggaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... .((((((..((((........))))..((((.......))))......((.((.......)).))))))))..... The cryo-EM structure of SDD1-stalled collided trisome.; tRNA (A/P) 6sv4 mb 77 3.3 RF00005 URS000041AF00_4932 32203490 0030533 0006412 4932 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... The cryo-EM structure of SDD1-stalled collided trisome.; tRNA (P/E) 6sv4 2c 1758 3.3 RF01960,RF01959,RF00177 URS00005F2C2D_4932 32203490 0003735 0005840 4932 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<...[[[[>>>>>[[[..((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{........[[[..................<.....<<.............>>......>.........<<<<<..<<....>>..>>>>>....((((((......<<<<<<<<<<<<..>>>>..............)))))).........<<<<..<<<.....>>>.>>>>....]]].....}}..]]].<<<....<<.....<<<<<<<<.......>>>>>>>>.>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<.<<<<<.......>.>>>>.>>.>>>......<<.................>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..)))))).]]].........[[[{{.......{{...[[[.{{.....<<<<<.<<<<<............>>>>>.>>>>>.....<<<<<<...............................>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[[..(((((((.....>>>>>>>>..))))))).]]].....}}....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<..<<<<<<<..<<.<<<<<<..<<<.<<<<<.......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<<<<<<<<....<<<.<<<<......>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>...>.>>>>>>>.....>.>>>>>....>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>......<....<<<<<<..........>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>.>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<...>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..)))).(((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((.(((......[[[[[[[.(((....))).....(......).))).)).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....((..(.(((...(....)...))).)...))......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..)))))))))...{......((({{...(.(.((...(((.((.....(((((.(.((......()......).)).))))).....((((((.....(......(.....)......).....))))))...(((((.((.......((..((.......))..((.....)).....))......)).))..)))..............(.((.(((.....]]]]]]].))).)).).........))....(((.((..(...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)..))..)))...)))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..(((.((((.((..........)))))).)))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].]((((...(((.((..((..(((((..(((.((((((......((........))..........(((((.(....(((((........(..(((........)))..)......)))))...((.(((...(.((((((....(((.((.((....))...(.((......)))...)).)))....(((((.((..((((..(((((..(((((....)))))....)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....((((((((.......))))))))......))...)).)))..)).))....(..((.(..((((.((..(.((((((((.(((..(.((..(...(((((...)))))...)..)).)..))).)))))))))..)).))))...).))...).....(((((((((....)))))))))>........ The cryo-EM structure of SDD1-stalled collided trisome.; 18S rRNA 6sv4 ZQ 3127 3.3 RF02540,RF02543 URS000061F377_4932 32203490 0003735 0005840 4932 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguuaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<<.<<<<<<<<<<<<<<<<<<<<.....<<<<......>>>>.(.......<<<......)>>>....>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<......<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<......>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<......<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>....>>>>>>.>>>>..>>>>>>><<<<<<<<<......>>>>>>>>>....>>>>>><<.<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>..>>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<....>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<...............>>>>><<.<<<<<<<<<<<..>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<....<<<<<....>>>>.>...>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<...>>>>>>>...<<<<<.....<<<<..<<<..........>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>..>>........<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>.....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>....<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<.<..<<<<........>>>>..>>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((.(((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))).....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.(((((......(((((((((((((.(((((((((.......(((((((......((((((....)))))).......))))))).....))))).)))).)))))........(((....)))....)))))))).....))))).))))).<((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))..).))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...(.((((.....)))).).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.......(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((......)))))))))....))))))((((((((((.((......((((.((((....))))))))...)))))))))).)).....))))))((.....((.....((((((.......))))))((((.....((((..((..(((((((...((.....)).))))))....[[(((.((...((....(((....)))........((((....))))....))....))...(((((........)))))]]((((..(((.(.(...((((....)))...(.[[((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....).)...))).)))).))).))).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.((((((((((.(.)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.....((.....((((....)))).....))..))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.((((((((..((((((.(..)))))))....((((.....((((..(((.(......).)))..........]]...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..(((.....{...)))..))))(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.............))))...)))).))))....))))))))....((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((..((....((((.(..((((((..)..)))))..)))))...)).....)))).)))))).))))).. The cryo-EM structure of SDD1-stalled collided trisome.; 25S rRNA 6sv4 ZR 121 3.3 RF00001 URS000055688D_4932 32203490 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<....<<<.<<..............>>....>>...>>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). The cryo-EM structure of SDD1-stalled collided trisome.; 5S rRNA 6sv4 ZS 157 3.3 RF00002 URS00004A45D3_4932 32203490 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>.................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....))))))))).................... The cryo-EM structure of SDD1-stalled collided trisome.; 5.8S rRNA 6sv4 nc 76 3.3 RF00005 URS00008FED3A_4932 32203490 0030533 0006412 4932 gcccggauagcucagucgguagagcaggggauuaggaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... .((((((..((((........))))..((((.......))))......((.((.......)).))))))))..... The cryo-EM structure of SDD1-stalled collided trisome.; tRNA (A/P) 6sv4 mc 77 3.3 RF00005 URS000041AF00_4932 32203490 0030533 0006412 4932 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... The cryo-EM structure of SDD1-stalled collided trisome.; tRNA (P/E) 6sw9 2 1497 4.2 RF00177,RF01959,RF01960 URS00021ED9A4_272844 32029867 0003735 0005840 272844 auucngguugauccugccggaggccacugcuaugggggucngacuaagccaugcgagucaagggggcgucccuucugggacgccaccggcggacggcucaguaacacgucgguaaccuacccucgggagggggauaaccccgggaaacuggggcuaaucccccauaggccugggguacuggaagguccccaggccgaaagggagccguaaggcuccgcccgaggaugggccggcggcngauuagguaguuggugggguaacggcccaccaagcngaagaucgguacgggcngugagagcgggagccnggagauggacacugagacacggguccaggcccuacggggcgcagcaggcgcganaccucngcaaugcgggaaacngcgacggggggacccccagugccgugccucuggcacggcuuuuccggaguguaaaaagcuccgggaauaagggcugggcaaggcngguggcagccgccgcgguaauaccggcggccngagugguggccacuauuauugggccuaaagcggcnguagccgggcccguaagucccuggcgaaaucccacggcucaacnguggggcucgcuggggauacugcgggccuugggacngggagaggcnggggguaccccngggguaggggugaaauccuauaaucccggggggaccgccaguggcgaaggcgccnggcuggaacgggucngacggugagggcngaaggccaggggagcgaacnggauuagauacccggguaguccuggcuguaaaggaugcgggcuaggugucgggcgagcuucgagcucgcccggugcnguagggaagcnguuaagccngcngccuggggaguacggcngcaaggcugaaacuuaaaggaauuggcgggggagcacuacaagggguggagcgugcgguuuaauuggaunnaacgccgggaaccucacngggggcgacggcaggaugaaggccaggcugaaggucuugccggacgcgccgagaggaggugcauggccgcngucagcucguacngugaggcguccacuuaagugugguaacgagcgagacccgcgcccccaguugccagucccucccgcucgggagggaggcacucuggggggacugccggcgauaagcnggaggaaggggcgggcgacgguaggucaguaugcccngaaaccccngggcuacangcgcgcuacaaugggcgggacaaugggugcngacccngaaagggggagguaauccccuaaacccgcccucaguucggaucgcgggcugcaacucgcccgcgugaagcuggaaucccuaguacccgcgcgucaucaucgcgcggcgaauacgucccugcuccuugcacacaccgncngucacuccacccgagcggggccuaggugaggcccgaucuccuucgggaggucgggucgagccuaggcuccgugaggggggagaagucgnancaagguagcnguaggggnnccuacggcucgaucaccuccu ...<<<<<.[.((((>>>>>.<<<<<<<<<..<<<<<<.<<......<<<.<<<..<<<..<<.<<<<<<<<....>>>>>>>>.>>>>>......<<........<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<<....>>>>>>.....>>>>>...<<<<<<<<<.<<......>>>>>>>>>>>.....<<<<<<....>>>>>>.>>>>>>>..>>>>>>>>>.<<<....<<<...<<<<<<.........>>>>>>.>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<............>>>>>.<<<<<..>>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<<<<<...>>>>>>>>...<<<<<<<<.......>>>>>>>>.....<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<....<<<<<<<<.....>>>>>>>>...>>>>>>>>..>>>>>>>>>...<<<<<.<....<<<<<<<.<..<<<<<<<<<..<<<......>>>.....>>>>>>>>>..>........<<....>>.>>>>>>>....>>>.>>>...>>>...>>>>...<<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>>.........<<<<<<..<<<<<<<<<<<<<<.....>>>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<...<<<<........<<<.<<<.......>>>.>>>......>>>>...<<.<<<..<<<<<<<<.....<<<<<<.<<....>>...<<<<......>>>>..>>>>>>....<<<<<.<<<<<<<..<<<..<<<<<<<<....>>>>>>>>>>>...>>>>>>>.....<<<<<.....>>>>>........>>>>>.....>>.>>>...>>>>>>>>....>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<...<<<<....>>>>...>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>.....<<<<<<<.......>>>>>>>.......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<...<...<<<<<<<<<..<<<<<<<<<<<<....>>>>>>>>>>>>..>>>>>>>>>...>...>.>>>>>..>.>>..........<<<<<<<<....>>>>>>>>............. ...[.[[..(.(((..]].].(((((((((..((((.(..((.....(((.(((..(((..((.((((((((....)))))))).)))))......(((.......(((((((..((...(((((((.(((((....((((((....)))))).....)))))...(((((((((.((......))))))))))).....((((((....)))))).)))))))..))))))))).(((....((....((((((.........))))))..))......)))..(..((..(....)..)...)..)))).(((((............))))).((((....))))...)))))).).....(.(((.....(((....)))...)))).)..).))))..((((((((...))))))))....(((((((.......)))))))..........([[....(.((((.....((..]])).......))))))......)))))))))..........((([[.....((((...(((..((((((.((((((((((.....(((.(.(.....).).)))....))))))))..))))))))...(((((((......((((((((..((((((((...((........))......))))))))..)).......((....)).)))))).....))).)))..))))...))))....((((((...((...((((.........))))...))))))).).........((.(((..(((.((((((((((.....)))))))))).)))....(..]])......))).).)))).(.(......(..........)....).)...))).)(((.(.((((((.......(((.(..((((((((((......((........))..........((.((((...((((.(......(((.((((.....)))).)))...)..))))...(..((......((.(((....((((((..(....)....((((......))))..))))))....(((((.(((((((....(...(((((((....)))))))..)....)))))))..(..(((((.....))))).....)..)))))....)))..)).......)).)....)))).))...)).)))))))).(...(((((((.....(((...(..((.(....).))...)....))).....)))))))......(....(((((((........)))))))....)..)..).)))......(.(((((.......))))).).............))))))).).))..(.(...(.(.((((.(((......(((((((((..(((((((.((((....)))).)))))))..)))))))))......))).))))..).)....)..).........((....))................... IC2A model of cryo-EM structure of a full archaeal ribosomal translation initiation complex devoid of aIF1 in P. abyssi; 16S ribosomal RNA 6sw9 5 20 4.2 32029867 272844 uggaggugauuuaaaugcca .................... .................... IC2A model of cryo-EM structure of a full archaeal ribosomal translation initiation complex devoid of aIF1 in P. abyssi; mRNA 6sw9 4 76 4.2 RF00005 URS0000A76384_562 32029867 0030533 0006412 562 gcggggnggagcagccuggnagcucgucgggnucauaacccgaagaucgucggnucaaauccggcccccgcuacca .<<<<<..<<.<.........>.>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>...... .(((((..((((......[..)))).(((((.......))))).....(.(((..]....))).))))))...... IC2A model of cryo-EM structure of a full archaeal ribosomal translation initiation complex devoid of aIF1 in P. abyssi; initiator Met-tRNA fMet from E. coli (A1U72 variant) 6swa q 3612 3.1 RF02540,RF02543 URS00021ED8FB_10090 33357414 0003735 0005840 10090 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccgcgcggggcgugggaaauguggcguacggaagacccacuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggccccggcgccgggcucgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcggcccggcggaucuuucccgcccccggggucggcgggggaccgucccccggaccggcgaccggccgccgccgggcgcauuuccaggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucggggcccccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcgcucuccccccugggggggccgggccaccccucccacggcgcgaccgcucucccagggggcggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccggggggccacgcgcgcgucccgggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgaggggcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcccacgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggccuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcaccuuugcugggguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcuggcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacaugagagguguagaauaagugggaggcccgggccgccggugaaauaccacuacucugaucguuuuuucacugacccggugaggcgggggggcgagcccgaggggcucucgcuucuggcgccaagcgcccgcccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucgccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccgguccgggguccggugcggagugcccuucguccugggaaacggggcgcggccggaaaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuuguc .........................<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..[[[..<...<...<.<<<<.<<<.....>>>>>>>.>.....>..>...<.<<..<<......<...<<.<<<...<<<<........<.<........>..>.................................>>>>>>>>>...>....>>..>>.>.......<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<..........<<.<..<<<....<<.<..<..<<........<<.<<<..<<....<<<<.<<<..<<<<<<<<<.>>>..>>>>>>>>>>>>>>>.>.>>>>..........>>.>..>.>>....>>>..>.>>.....<<<<<<<<.<<<<<<<<<<.<<<........<.<<<<.<<<<......<<<<<<<<.>>>>>>>>........>>>>>>>>>...........>>>...>>>>>>>>>>....................<<<....<<<<<<..>>>>>>..<.<<<......<<...<.<<<<<<<<<<...<<...>>.<<<<<<<.<<<<....>>>>.>>>>>>>>>>>>.>>>>>>....>>........>>>..>.....<<<<<..>>>>>..........>>>......>>>.>>>>>....>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<..........>>>.....>>>...<<....>>...<<<<<<<......>>>>>>>..<<<<<..<<<...<..............>...>>>...>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<........<<<.<<<<<<<<<...<<<....<<<....<<<..<<<<<<.........>>>>>>>>>....>>>..>>.>...>>>>>>>...<<<<<<<<<.<......>>>>>>>.>>>..>>>>>>>>>>>>.>>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<.......>.>>>>>>....>>>>>>.<<<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>.>>.....>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>.............<<<<<<<<<...>>>>>>>>>........>>....>>...<<<<<........>>>>>))<<<<....<<<<<...<<<<<<<....>>>>>>>...<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<<<<<<<<<<<<..{{{..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>........<.<<......>>..>...>>>>.>.>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<...............<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<.>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<.........>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<<.<<<<<<<<<<<<.<<<<..........<<<<<..<<<<..>>>>............>>>>>.>>>>.>>.>>>>>>>>>>...<<<<<.....<<<<.......<<<<...>>>.>.................<<<<<<<......>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..(((..>>>>>>.)))))))))..........]]]]..}}]]]].......<<..<<.<<<<<<...<<.......>>...>>>>>>...>>..>>.......<.<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>..>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]].....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<..<<<<<<}}}.>>>>>..>..>>...>>>>...>>>><<<<....<<<<<...........>>>>>....>>>>.>>>...>.>>>>>>.....<<<<<<<.<<..<<<...................<.<<<.>>>>..................<<<..<<<<.........<<<<<.<......>.>>>>>.......>>>>..>>>..............>>>...>>>>>>>>><<<<<.<.............>.....<.<<<<<<<.<<.....<<<<....<<<<<......>>>>>...>>>>....>>....>>>>.>>>.>...>>>>>... .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...(((......(...(.(((..(((.....))).))).).....)......(.(...((......(...((.((....((((.........((........).).......(...)......................)))).))))...)....))...).).......(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))...............((.(....).))..................................((((((((..(((.......(..((.(.........((.(..(..(........(((..(((.(......(((.(((..(((((.(((.)))...)))))))))))..))).).)).)........)..)..).)).........).))..)...((((((..((((.(((((.(((..........(((..((((........((((((.))))))..........)))).)))............)))...))))).))))....................(((....((((((..))))))....(((..(.(..(...(.(((((((((....((...)).(((((((..(((....)))..))))))).)))).))))))....).....).).))).........((((()))))...........))).......)).)))).....)))...)))))))).[((((........))))((((((....(((((((((((((..(((..((((..........)))..)..)))...((....))...(((((((......)))))))..(((((...((...(..............)...))....))))).(((((((((.((((......))))))))))).))....)))))))))))))..((.(...((((((.....((.((((((..((((...(((((((....)))))))...)[)))...(((..((.((........)))).)))....)))))).)).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((........(((.((((((((....(((....(((..(.(((...(((((.(.....).))))).))).)..)))..)).)....))))))....((((((((.(......))))))).))...))))))))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[.....(.(((((......(..........(((.(.((((((((.......(((((..((....(.........)....))..........((......))...)))))...)))))))).))))..........]]].)....)))))).)))...)))))))((((((.(.......).))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((..(((((((....(.....)..))))))....[[(((.((...((....(((....)))...........(.((((.((((...)))).))))).......))....))...(.(((........))).)]]((((....(((((...((.((((....)))).))...(((....)))...(...((((.....((((((((((((((((((.(((...{{{...))).)....(.(((.((((.((((.....((.......)).....))))))))..))).).........(((......)).)....)))).).))))))))))))(...)......))))...)..........)).))).)))).))).))).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((((.()))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(...(((..((((((.....((.....((((....)))).....))..))))..)))))(.(((.........))).)........((.(......).(((((.......)))))..)..)......)....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.))))).....((((..(((.((......((((.((((((..(((((.(((((((((.(((((.(.((((.((((.......[...((((..((((()))))..........].))))..)))).)).)).).)))))...(((((.....(((.(........((...))....................(((((((......)))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((....((((((.(.((((((.......))))))...).((]..[[[))....)))))).....((..((((....{..))))..))..(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((...(.((((((...((.......))...))))))...)..).)........((((.((((((..(.(.(((((......)))))...).).(((.........))).....)))))..)...))).).....(((((((....))).))))....))..))).))))......((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}}.)))))..)).))...))))...)))).((((...((((.............))))...))))..)))...).))))))......(((((..((..((......(................((.))...............)....(((..((((.....(.(.(((((.(......).)))))).)....))))..)))...............))...)).))))).(((((.(..(.......)..).....(.(((((((.((.....((((.(..(((((......)))))..)))))....))....)))).))).)...)))))... Mus musculus brain neocortex ribosome 60S bound to Ebp1; 28S ribosomal RNA 6swa r 157 3.1 RF00002 URS0000005270_10090 33357414 0003735 0005840 10090 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>.............>>>..)...>>>....<<....>><<<<<<<<.......>>>>>>>>..................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))(((((((.........)))))))..................... Mus musculus brain neocortex ribosome 60S bound to Ebp1; 5.8S ribosomal RNA 6swa s 119 3.1 RF00001 URS000064027A_10090 33357414 0003735 0005840 10090 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcu .<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>.. ..((((.((....((((((((.....((...(...(....)...).....))....)))))).))(((.((......((.((..((....)).)).)).....)).))))).))))... Mus musculus brain neocortex ribosome 60S bound to Ebp1; 5S ribosomal RNA 6swc 2 1497 3.3 RF00177,RF01959,RF01960 URS00021ED9A4_272844 32029867 0003735 0005840 272844 auucngguugauccugccggaggccacugcuaugggggucngacuaagccaugcgagucaagggggcgucccuucugggacgccaccggcggacggcucaguaacacgucgguaaccuacccucgggagggggauaaccccgggaaacuggggcuaaucccccauaggccugggguacuggaagguccccaggccgaaagggagccguaaggcuccgcccgaggaugggccggcggcngauuagguaguuggugggguaacggcccaccaagcngaagaucgguacgggcngugagagcgggagccnggagauggacacugagacacggguccaggcccuacggggcgcagcaggcgcganaccucngcaaugcgggaaacngcgacggggggacccccagugccgugccucuggcacggcuuuuccggaguguaaaaagcuccgggaauaagggcugggcaaggcngguggcagccgccgcgguaauaccggcggccngagugguggccacuauuauugggccuaaagcggcnguagccgggcccguaagucccuggcgaaaucccacggcucaacnguggggcucgcuggggauacugcgggccuugggacngggagaggcnggggguaccccngggguaggggugaaauccuauaaucccggggggaccgccaguggcgaaggcgccnggcuggaacgggucngacggugagggcngaaggccaggggagcgaacnggauuagauacccggguaguccuggcuguaaaggaugcgggcuaggugucgggcgagcuucgagcucgcccggugcnguagggaagcnguuaagccngcngccuggggaguacggcngcaaggcugaaacuuaaaggaauuggcgggggagcacuacaagggguggagcgugcgguuuaauuggaunnaacgccgggaaccucacngggggcgacggcaggaugaaggccaggcugaaggucuugccggacgcgccgagaggaggugcauggccgcngucagcucguacngugaggcguccacuuaagugugguaacgagcgagacccgcgcccccaguugccagucccucccgcucgggagggaggcacucuggggggacugccggcgauaagcnggaggaaggggcgggcgacgguaggucaguaugcccngaaaccccngggcuacangcgcgcuacaaugggcgggacaaugggugcngacccngaaagggggagguaauccccuaaacccgcccucaguucggaucgcgggcugcaacucgcccgcgugaagcuggaaucccuaguacccgcgcgucaucaucgcgcggcgaauacgucccugcuccuugcacacaccgncngucacuccacccgagcggggccuaggugaggcccgaucuccuucgggaggucgggucgagccuaggcuccgugaggggggagaagucgnancaagguagcnguaggggnnccuacggcucgaucaccuccu ...<<<<<.[.((((>>>>>.<<<<<<<<...<<<<<<.<<......<<<.<<<..<<<..<<.<<<<<<<<....>>>>>>>>.>>>>>......<<........<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<<<<<.<<......>>>>>>>>>>>.....<<<<<<....>>>>>>.>>>>>>>..>>>>>>>>>.<<<....<<<...<<<<<<<.......>>>>>>>.>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<............>>>>>.<<<<<..>>>>>...>>>>>>......<<.<<<....<<<<....>>>>..>>>>>>>.>>>>>>..<<<<<<<<...>>>>>>>>...<<<<<<<<.......>>>>>>>>.....<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>...>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<....<<<<<<<<.....>>>>>>>>...>>>>>>>..>>>>>>>>>>...<<<<<<.....<<<<<<<.<..<<<<<<<<<..<<<......>>>.....>>>>>>>>>..>........<<....>>.>>>>>>>....>>>.>>>...>>>...>>>>...<<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>>.........<<<<<<..<<<<<<<<<<<<<<.....>>>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<...<<<<........<<<.<<<.......>>>.>>>......>>>>...<<.<<<..<<<<<<<<.....<<<<<<.<<....>>...<<<<......>>>>..>>>>>>....<<<<<.<<<<<<<..<<<..<<<<<<<<....>>>>>>>>>>>...>>>>>>>.....<<<<<.....>>>>>........>>>>>.....>>.>>>...>>>>>>>>....>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>.....<<<<<<<.......>>>>>>>.......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<...<<<<<<<<<<<<..<<<<<<<<<<<<<..>>>>>>>>>>>>>..>>>>>>>>>>>>...>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>............ ...((((..[.[[[..)))).(((((((((..((((((.(((.....(((.((...(((..((.((((((((....)))))))).)))))......(((.......(((((((..((...(((((((.(((((....((((((....)))))).....)))))...(((((((((.((......))))))))))).....((.(((....))).)).)))))))..))))))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))....))))).).....(.(((...(((((....)))).))))).)).))))))..((((((((...))))))))....(((((((.......)))))))......((((([[....(.((((.....((..]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((.....(((((((.....)))))))....))))))))..)))))))))..(((((((.....(((((((((..((((((((...((........))......))))))))..)).......((....)).)))))))....))).)))..))))...))))...(((((((...((...((((.........))))...))))))))).....{...((((((..((((((((((((((.....))))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..((((((((((......((........))..........(((((((...((((.(......(((.((((.....)))).)))...)..))))...((.(((...(.((((((....((((((.((....))...((((......))))..))))))....(((((.(((((((...((..((((((((....))))))))))....)))))))..(..(((((.....))))).....)..)))))....))).)))....).)))))....)))))))...)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..)))))......(((((((.......))))))).......))...)))))))))).))..(.(..((.(.((((.(((....((.((((((((..((((((((((((....))))))))))))..)))))))).))....))).))))..).))...)..)..(((((((((....)))))))))}........... IC2B model of cryo-EM structure of a full archaeal ribosomal translation initiation complex devoid of aIF1 in P. abyssi; 16S ribosomal rRNA 6swc 5 20 3.3 32029867 272844 uggaggugauuuaaaugcca .................... .................... IC2B model of cryo-EM structure of a full archaeal ribosomal translation initiation complex devoid of aIF1 in P. abyssi; mRNA 6swc 4 76 3.3 RF00005 URS0000A76384_562 32029867 0030533 0006412 562 gcggggnggagcagccuggnagcucgucgggnucauaacccgaagaucgucggnucaaauccggcccccgcuacca .<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>...... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... IC2B model of cryo-EM structure of a full archaeal ribosomal translation initiation complex devoid of aIF1 in P. abyssi; initiator Met-tRNA fMet from E. coli (A1U72 variant) 6swd 2 1044 3.2 RF01959,RF00177,RF01960 URS00021ED983_272844 32029867 0003735 0005840 272844 auucngguugauccugccggaggccacugcuaugggggucngacuaagccaugcgagucaagggggcgucccuucugggacgccaccggcggacggcucaguaacacgucgguaaccuacccucgggagggggauaaccccgggaaacuggggcuaaucccccauaggccugggguacuggaagguccccaggccgaaagggagccguaaggcuccgcccgaggaugggccggcggcngauuagguaguuggugggguaacggcccaccaagcngaagaucgguacgggcngugagagcgggagccnggagauggacacugagacacggguccaggcccuacggggcgcagcaggcgcganaccucngcaaugcgggaaacngcgacggggggacccccagugccgugccucuggcacggcuuuuccggaguguaaaaagcuccgggaauaagggcugggcaaggcngguggcagccgccgcgguaauaccggcggccngagugguggccacuauuauugggccuaaagcggcnguagccgggcccguaagucccuggcgaaaucccacggcucaacnguggggcucgcuggggauacugcgggccuugggacngggagaggcnggggguaccccngggguaggggugaaauccuauaaucccggggggaccgccaguggcgaaggcgccnggcuggaacgggucngacggugagggcngaaggccaggggagcgaacnggauuagauacccggguaguccuggcuguaaaggaugcgggcuaggugucgggcgagcuucgagcucgcccggugcnguagggaagcnguuaagccngcngccuggggaguacggcngcaaggcugaaacuuaaaggaauuggcgggggagccugcuccuugcacacaccgncngucacuccacccgagcggggccuaggugaggcccgaucuccuucgggaggucgggucgagccuaggcuccgugaggggggagaagucgnancaagguagcnguaggggnnccuacggcucgaucaccuccu ...<<<<<.[.((((>>>>>.<<<<<<<<...<<<<<<.<<......<<<.<<<..<<<..<<.<<<<<<<<....>>>>>>>>.>>>>>......<<........<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<<<<<.<<......>>>>>>>>>>>.....<<<<<<....>>>>>>.>>>>>>>..>>>>>>>>>.<<<....<<<...<<<<<<<.......>>>>>>>.>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<............>>>>>.<<<<<..>>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<<<<<...>>>>>>>>...<<<<<<<<.......>>>>>>>>.....<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>...>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<....<<<<<<<<.....>>>>>>>>...>>>>>>>..>>>>>>>>>>...<<<<<<.....<<<<<<<.<..<<<<<<<<<..<<<......>>>.....>>>>>>>>>..>........<<....>>.>>>>>>>....>>>.>>>...>>>...>>>>...<<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>>.........<<<<<<..<<<<<<<<<<<<<<.....>>>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<......>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<<..<<<<<<<<<<<<....>>>>>>>>>>>>..>>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>............ ...((((..[.[[[..)))).(((((((((..((((((.(((.....(((.(((..(((..((.((((((((....)))))))).)))))......(((.......(((((((..((...(((((((.(((((....((((((....)))))).....)))))...(((((((((.((......))))))))))).....((.(((....))).)).)))))))..))))))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((((((...))))))))....(((((((.......)))))))......((((([[....(.((((.....((..]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((.....(((((((.....)))))))....))))))))..)))))))))..(((((((.....(((((((((..((((((((...((........))......))))))))..)).......((....)).)))))))....))).)))..))))...))))...(((((((...((...((((.........))))...))))))))).....{...((((((..((((((((((((((.....))))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((....)))))))).))..(.(..((.(.((((.(((...(.((((((((((..((((((((((((....))))))))))))..)))))))))).)...))).))))..).))...)..)..(((((((((....)))))))))}........... IC2 body model of cryo-EM structure of a full archaeal ribosomal translation initiation complex devoid of aIF1 in P. abyssi; 16S ribosomal RNA 6swd 5 20 3.2 32029867 272844 uggaggugauuuaaaugcca .................... .................... IC2 body model of cryo-EM structure of a full archaeal ribosomal translation initiation complex devoid of aIF1 in P. abyssi; mRNA 6swe 2 468 3.1 RF01959,RF00177,RF01960 URS0001A16A81_272844 32029867 0003735 0005840 272844 guaaggcgggggagcacuacaagggguggagcgugcgguuuaauuggaunnaacgccgggaaccucacngggggcgacggcaggaugaaggccaggcugaaggucuugccggacgcgccgagaggaggugcauggccgcngucagcucggcguccacuuaagugugguaacgagcgagacccgcgcccccaguugccagucccucccgcucgggagggaggcacucuggggggacugccggcgauaagcnggaggaaggggcgggcgacgguaggucaguaugcccngaaaccccngggcuacangcgcgcuacaaugggcgggacaaugggugcngacccngaaagggggagguaauccccuaaacccgcccucaguucggaucgcgggcugcaacucgcccgcgugaagcuggaaucccuaguacccgcgcgucaucaucgcgcggcgaauacgucccugcuccuu .........<<<<<<<..<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<...<<<<........<<<.<<<.......>>>.>>>......>>>>...<<.<<<..<<<<<<<<.....<<<<.....<<<<......>>>>....>>>>....<<<<<.<<<<<<<..<<...<<<<<<<<....>>>>>>>>.>>...>>>>>>>.....<<<<<.....>>>>>........>>>>>.....>>.>>>...>>>>>>>>....>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>.....<<<<<<<.......>>>>>>>.......>>...>>>>>>>. .......(.(((((((..(...(((((..((((((((((......((........))..........(((((((...((((.(......(((.((((.....)))).)))...)..))))...((.(((...(.((((((....(((((....((((......))))...)))))....(((((.(((((((..(((...(((((((....))))))).)))...)))))))..(..(((((.....))))).....)..)))))....))).)))....).)))))....)))))))...)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..)))))......(((((((.......)))))))........)...)))))))) IC2 head of cryo-EM structure of a full archaeal ribosomal translation initiation complex devoid of aIF1 in P. abyssi; 16S ribosomal RNA 6swe 4 18 3.1 URS0001A16A83_562 32029867 562 gucgggnucauaacccga .<<<<<.......>>>>> .(((((.......))))) IC2 head of cryo-EM structure of a full archaeal ribosomal translation initiation complex devoid of aIF1 in P. abyssi; initiator Met-tRNA fMet from E. coli (A1U72 variant) 6sx0 C 19 1.75 URS00021ED96E_32630 32867106 32630 gguaacuguuacaguuacc ................... ................... Specific dsRNA recognition by wild type H7N1 NS1 RNA-binding domain; RNA (5'-R(*GP*GP*UP*AP*AP*CP*UP*GP*UP*UP*AP*CP*AP*GP*UP*UP*AP*CP*C)-3') 6sx0 D 19 1.75 URS00021ED96E_32630 32867106 32630 gguaacuguuacaguuacc ................... ................... Specific dsRNA recognition by wild type H7N1 NS1 RNA-binding domain; RNA (5'-R(*GP*GP*UP*AP*AP*CP*UP*GP*UP*UP*AP*CP*AP*GP*UP*UP*AP*CP*C)-3') 6sx2 C 19 1.9 URS00021ED96E_32630 32867106 32630 gguaacuguuacaguuacc ................... ................... dsRNA recognition by R38AK41A mutant of H7N1 NS1 RNA Binding Domain; RNA (5'-R(*GP*GP*UP*AP*AP*CP*UP*GP*UP*UP*AP*CP*AP*GP*UP*UP*AP*CP*C)-3') 6sx2 D 19 1.9 URS00021ED96E_32630 32867106 32630 gguaacuguuacaguuacc ................... ................... dsRNA recognition by R38AK41A mutant of H7N1 NS1 RNA Binding Domain; RNA (5'-R(*GP*GP*UP*AP*AP*CP*UP*GP*UP*UP*AP*CP*AP*GP*UP*UP*AP*CP*C)-3') 6szs A 2903 3.06 RF02540,RF02541 URS000080E25C_83333 31776341 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<<..>>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<<.....>>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<......<<<<.......>>>>.............<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<.<<.................<............<<<<............>>>>...................>........>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......((((.((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))).))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))..(((((((..((((((((((.....(((...(((.((((...((.((((.....))))..))...)))).)))..)).).....)))))).)))..)))))))).....((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(.(.....{..((((.(....((((.......))))....).....(..(((......)))).))))....).)..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((..(.....(.............(.............(.(..........).)....................)....)......).)))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....((.((((....))).).))..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Release factor-dependent ribosome rescue by BrfA in the Gram-positive bacterium Bacillus subtilis; 23S ribosomal RNA 6szs B 120 3.06 RF00001 URS0000049E57_83333 31776341 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Release factor-dependent ribosome rescue by BrfA in the Gram-positive bacterium Bacillus subtilis; 5S ribosomal RNA 6szs a 1540 3.06 RF00177,RF01959,RF01960 URS0000D56C37_83333 31776341 0003735 0005840 83333 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<<....>>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((.(((((((..)))))))..)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....(((.((((.......)))).))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((...((.(((....))).))....(......)..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....))))))))..)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Release factor-dependent ribosome rescue by BrfA in the Gram-positive bacterium Bacillus subtilis; 16S ribosomal RNA 6szs x 77 3.06 RF00005 URS00001DEEBE_83333 31776341 0030533 0006412 83333 cggugauuggcgcagccugguagcgcacuucguucgggacgaaggggucggagguucgaauccucuaucaccgacca <<<<<<<..<<<<.........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))).... Release factor-dependent ribosome rescue by BrfA in the Gram-positive bacterium Bacillus subtilis; P-site tRNA-Pro(CGG) 6szu V 44 2.41 URS0001A16A94_11520 32304664 11520 aguaguaacaagagcaauguguccgucucgccucugcuucugcu .<<....>>................................... .((....))................................... Bat Influenza A polymerase pre-termination complex with pyrophosphate using 44-mer vRNA template with mutated oligo(U) sequence; vRNA 6szu M 10 2.41 32304664 11520 gacggacaca .......... .......... Bat Influenza A polymerase pre-termination complex with pyrophosphate using 44-mer vRNA template with mutated oligo(U) sequence; mRNA 6szv R 18 2.5 URS0000EEAD16_11520 32304664 11520 uauaccucugcuucugcu .................. .................. Bat Influenza A polymerase elongation complex with incoming UTP analogue (core + endonuclease only); 3' vRNA 6t0n V 14 2.54 URS000080E200_11520 32304664 11520 aguaguaacaagag .<<....>>..... .((....))..... Bat Influenza A polymerase pre-initiation complex; 5' vRNA 6t0n R 15 2.54 URS0001A16A8E_11520 32304664 11520 accucugcuucugcu ............... ............... Bat Influenza A polymerase pre-initiation complex; 3' vRNA 6t0s V 33 3.04 URS0001A16A7A_32630 32304664 32630 aguaguaacaagauuuuuuccgucucuucugcu .<<....>>........................ .((....))........................ Bat Influenza A polymerase stuttering complex using 44-mer vRNA template with intact oligo(U) sequence; vRNA 6t0s M 10 3.04 32304664 32630 acggaaaaaa .......... .......... Bat Influenza A polymerase stuttering complex using 44-mer vRNA template with intact oligo(U) sequence; mRNA 6t0v R 18 3.02 URS0000EEAD16_1129347 32304664 1129347 uauaccucugcuucugcu .................. .................. Bat Influenza A polymerase elongation complex with incoming UTP analogue (complete polymerase); 3' vRNA 6t0v M 12 3.02 32304664 1129347 naaaagcagagg ............ ........... Bat Influenza A polymerase elongation complex with incoming UTP analogue (complete polymerase); Capped mRNA 6t3k A 390 3.44 RF02001,RF01998 URS0001A24B61_182710 32503992 0000373 182710 gugugcccggcaugggugcagucuauagggugagagucccgaacugugaaggcagaaguaacaguuagccuaacgcaaggguguccguggcgacauggaaucugaaggaagcggacggcaaaccuucggucugaggaacacgaacuucauaugaggcuagguaucaauggaugaguuugcauaacaaaacaaaguccuuucugccaaaguugguacagaguaaaugaagcagauugaugaagggaaagacugcauucuuacccggggaggucuggaaacagaagucaggagaagucauaguacccuguucgcaggggaaggacggaacaaguauggcguucgcgccuaagcuugaacggccguauaccgaacgguacguacggucgugug .....<<<<<...<<<<<<<<<<<...<<<.......>>>..<<<<<...(((((((...>>>>>..<<<...<<<..<<<<.<<<<<<....>>>>>>>>>>.......>>>...>>>...<<<<<<<<<<<...........<<<<<......<<<..<<<<<<<<<<<<..<<<<........>>>>...>>>>.)))))))...>>>>>>>>..>>>...>>>>>>>>>>...>>>>>>...>>>>>>>>>>>....>>>>>....<<<<....>>>>...........<<<......<<<<......>>>>....>>>....<<<<<..<<<<....>>>>...>>>>>.<<<<<<<<<<<<<....>>>..>>>>>>>>>>... ..[<.((((({..(((((((((((...(((.......)))..(((((...[[[[[[[...)))))..(((...(((..((((.((((((....))))))))))...>}..)))...)))...(((((((((((.(.....)...(((((.....[(((..((((.(((((((..((((.]......))))...)))).]]]]]]]...))).))))..)))...))))))))))...))))))...)))))))))))...])))))(...((((....))))...).......(((.(....(((........)))...))))....(((((..((((....))))...))))).(((((((((((((....)))..))))))))))... Structure of Oceanobacillus iheyensis group II intron G-mutant (C289G/C358G/G385C) in the presence of K+, Mg2+ and 5'-exon; Group IIC Intron Ribozyme 6t3r A 389 3.57 RF02001,RF01998 URS0001A24B48_221109 32503992 0000373 221109 ugugcccggcaugggugcagucuauagggugagagucccgaacugugaaggcagaaguaacaguuagccuaacgcaaggguguccguggcgacauggaaucugaaggaagcggacggcaaaccuucggucugaggaacacgaacuucauaugaggcuagguaucaauggaugaguuugcauaacaaaacaaaguccuuucugccaaaguugguacagaguaaaugaagcagauugaugaagggaaagacugcauucuuacccggggaggucuggaaacagaagucaguagaagucauaguacccuguucgcaggggaaggacggaacaaguauggcguucgcgccuaagcuugaacugccguauaccgaacgguacguacgguagugug ....<<<<<...<<<<<<<<<<<...<<<.......>>>..<<<<<...(((((((...>>>>>..<<<...<<<..<<<<.<<<<<<....>>>>>>>>>>.......>>>...>>>...<<<<<<<<<<<...........<<<<<......<<<..<<<<<<<<<<<<..<<<<........>>>>...>>>>.)))))))...>>>>>>>>..>>>...>>>>>>>>>>...>>>>>>...>>>>>>>>>>>....>>>>>....<<<<....>>>>...........<<<......<<<<......>>>>....>>>....<<<<<..<<<<....>>>>...>>>>>.<<<<<<<<<<<<<....>>>..>>>>>>>>>>... .[<.((((({..(((((((((((...(((.......)))..(((((...[[[[[[[...)))))..(((...(((..((((.((((((....))))))))))...>}..)))...)))...(((((((((((.(.....)...(((((.....[(((....((((((((((..((((.]......))))...)))).]]]]]]]...))))))....)))...))))))))))...))))))...)))))))))))...])))))(...((((....))))...).......(((.(....(((........)))...))))....(((((..((((....))))...))))).(((((((((((((....)))..))))))))))... Structure of Oceanobacillus iheyensis group II intron U-mutant (C289U/C358U/G385A) in the presence of K+, Mg2+ and 5'-exon; Group IIC Intron Ribozyme 6t4q C2 1771 2.6 RF01960,RF01959,RF00177 URS0001A16A88_4932 31858614 0003735 0005840 4932 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugagcuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauu ...<<<<<.{.((((>>>>><<<<.<<<<<<...<.<...<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<..<<..<<....<<<..................<<....<<.<<<.....>>>.>>.....>>.........<<<<<..<<....>>..>>>>><.<.<<<<<<......(((.{((.<.<....>.>..............>>>>>>.>...>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>..>>>..>....>.>.....<<<<<<<<<<<<<....>>>>>>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>>.........<<<[[.....<.<<...<<<.<<....<<<<<<.<<<<..............>>>>.>>>>>>.....<<<<<....................>>>>>....<<<<<.<<.......<<...<.......>..<<<<...>>>>....>>......>>.>>..>>>.........<<<..<<<<<<<<.....)).}))).>>>>>>>>.>>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..]]>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..)))).}<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<......<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<<<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>...>.>>>>>>>.......>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>......<....<<<<<<..........>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<.<<<<..............>>>>.>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>........ ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[[.[[[.(((....))).....(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(((((((.(.(((....))).).)))).)))....(.(((.(...........)).))......)..((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((................))).))))))....((((((....................))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(....(.((.(((.....]].]]]].))).)).)...).....))...((((.((.((...((((..((..((((((.(...((........))......).))))))..)).......((....))...))))..)).))..)))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].].((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....((((((((.......))))))))......))...)))))))))).)...(.(..((.(..((((.((..(.((((((((.(((..(.((..(...((((((..(((................)))..))))))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>....... Structure of yeast 80S ribosome stalled on the CGA-CCG inhibitory codon combination.; 18S rRNA 6t4q C4 121 2.6 RF00001 URS000055688D_4932 31858614 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<<............>>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Structure of yeast 80S ribosome stalled on the CGA-CCG inhibitory codon combination.; 5S rRNA 6t4q C3 158 2.6 RF00002 URS00001BF64E_4932 31858614 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Structure of yeast 80S ribosome stalled on the CGA-CCG inhibitory codon combination.; 5.8S rRNA 6t4q C1 3184 2.6 RF02540,RF02543 URS0001A16A76_4932 31858614 0003735 0005840 4932 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaugguguuuuguauuucacuggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauagagggcuaccuuuauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>...{.....<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<.<<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]....}.............................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<.........................<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<....<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>>.>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>..>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<.<.....>..>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<.<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>.>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<....>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.....<<.....<<<<....>>>>.....>>..>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<<<<<<<<<....>>>>>>>.>>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<<...<<<<<<<<<<}}}.>>>>>..>>>>>..>>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<.<..<<<<<......>>>>>..>>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.(((((.......(..............)..(((((((((((((((((((((((.......(((((((......((((((....)))))).......))))))).....))))).))))))))))........(((....)))....)))))))).....))))).))))).[((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((((((((((....((.(((((((.....(((....(((..(.((((...((((((.....)))))).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))((((((((((.((......((((.((((....))))))))...)))))))))).)).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........(((...(.....)....)))....))....))...(((((........)))))]]((((..(((.(((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....)))...))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((....)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((((((((((((....))))))).))))))))))....((((.....((((..((((........))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((.(((((....{..)))).)))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(((.((..)..).)))..)))))...)))....)))).)))))).))))).. Structure of yeast 80S ribosome stalled on the CGA-CCG inhibitory codon combination.; 25S rRNA 6t4q 5 30 2.6 31858614 4932 aauccuggauggaacgaccgcgaccguaaa ..................<<....>>.... ..................((....)).... Structure of yeast 80S ribosome stalled on the CGA-CCG inhibitory codon combination.; mRNA 6t4q 6 76 2.6 RF00005 URS000080E1EA_4932 31858614 0030533 0006412 4932 uuccucguggcccaauggucacggcgucuggcuicgaaccagaagauuccagguucaaguccuggcggggaagcca <<<<<<<..<<<..........>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..(((.....[....))).(((((.......))))).....(((((..]....)))))))))))).... Structure of yeast 80S ribosome stalled on the CGA-CCG inhibitory codon combination.; ICG tRNA Arg (P/P) 6t4q 7 75 2.6 RF00005 URS0000E60BA3_4932 31858614 0030533 0006412 4932 uccgauauagcguaacggcuaucacaucacgcuuucaccguggagaccgggguucgacuccccguaucggagcca <<<<<<<..<.<..........>.>.<<<<<.......>>>>>....<<<<<.......>>>>>>>>>>>>.... (((((((..(.(.....[....).).(((((.......)))))....(((((..]....)))))))))))).... Structure of yeast 80S ribosome stalled on the CGA-CCG inhibitory codon combination.; tRNA (E/E) 6t59 23 76 3.11 RF00005 URS0000868530_9986 31727855 0030533 9986 gucuccguaguguagcgguuaucacguucgccuaacacgcgaaagguccucgguucgaaaccgggcggaaacacca <<.<<<<..<<<..........>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>.>>.... ((.((((..(((.....[....))).(((((.......))))).....(((((..]....))))))))).)).... Structure of rabbit 80S ribosome translating beta-tubulin in complex with tetratricopeptide protein 5 and nascent chain-associated complex; P-site tRNA 6t59 54 3543 3.11 RF02540,RF02543 URS0000A7632C_9986 31727855 0003735 0005840 9986 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggaaauguggcguacggaagacccacuccccggcgccggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcgcgguccggccgugccggcggggcggaucucccgcucccgucggcgggggaccgccccccggccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggccccggcggggaagguggcccgggggccccggguguuacagccccgccccggcagcagcagcucgccgaaucccggggccgagggagcgagacccgugcgccgcgcucuccccccucgggggggccgggccaccccucccacggcgcgaccgcuggggcggacuguccagugcgccccgggcgggucgcgccgucgggcccggggggccacgcgucccccgcgagcgcacggggucggcggcgaugucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcuacgaaagccgccguggcgcaaugaaggugaaggccggcggcgcgccgccggccgaggugggaucccgaggccuuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcgaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccaaaguuucccucaggauagcuggcgcucuccgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcugguguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggaugguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgcuggcagucggcagagcgagaaagagaguggcgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucagccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcuggcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacguuuuuucacugacccggugaggcgggggggcgagccgggcucucgcuucuggcgccaagcgcccggccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauagcgccggagccucgguuggccucggauagccggucccccgccgggguccggugcggagagcccuucgucccgggaaacggggcggccggaaagggggccgcccucucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcugcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>>..<<<<<<<<<....<<<<<<<<..<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>...>>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<.<....<<<<<<<<.<<<.....<<<<<<<<<<....<<<<<<<.<<<<<.<<<<<<<.<<<<<<<<<......>>>>>>>>>>>>>>>>>>>>>>>>>...>>>.>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<<<<<<<<<<<<<<<<<...<<..<<<..<<<<<<<......<<<<<<<...>>>>>>>.......>>>>>>>..>>>.........>>>>>>..>>>>>>>>>>>.....<<.......>>.........<...<<<<<<..>>>>>>...<.<<..<<<.<<<<<<<<<<<<<<<<<<<<<<<.<<<<..>>>>.>>>>>>.>>>.>>>>>>>>>>>.>>>...>>>>>.>................>........>>>.>>>>>....>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<.....>>>>.....>>>...<<....>>...<<<<<<<<<<..>>>>>>>>>>..<<<<<...<<<..<<<....[[.[[.>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<<<...<<<....<<<..<.<<<..<<.<.<.<.....>.>.>.>>>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>>>>>>.>>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<..<<....<<.........>>....>>.......................>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<....................]].]].............>>>>>>>>>....>>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<<....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<<<<<...>>>>>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<..<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<<<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>.>.>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<.<<<<<<<<<<<.>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<....<<<<<....>>>>.>...>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>...>>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<<<..>>>>>>>>>...<<<<<.....<<<<..<<.<.<<..>.>>.>>..............<<<<<<<<<..>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>><<<<....>>>>>>)))].....<<<<<<<..<<<..)))))).>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>.>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<.]]]..>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.<<<<<<...<<<<....<<<........<<<<<...<<<<.>>>>..>>>>>.......>>>...<<<..<<<<....<<<<<<<<<........>>>>>>.>>>...>>>>..>>>..............>>>>....>>>>>>.<<<<<....................<<.<<<<<<<.<<.....<<<<.<..<<<<<.>>>>>..>>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..(((((((((((.....)))))).))))....))))....(((((((((....((((.(((..((((((((..({((((......)))))....[[(...).(((....}]])))...).)))))))...))).))))...)))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....((((((((((.(..(((((.(.(((((.(((((((.((.((((.(......).)))).))))))))))))))).))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((..(((((((......((((((((.)))))))).......)))))))..))).........))))))..))))))))))).....((.....{.)).............((((((..))))))...(.((..(((.((((((((((((((....(((((.((((..)))).)))))......))))))))))).)))...))))).)............[............))).)))))...)))))...)))))))).<((((........))))((((((....(((((((((((((..(((..((((.......)))..)..)))...((....))...((((((((((..))))))))))..(((((...(((..(((]...[[.[[[)))..)))....))))).(((((((((.((((......))))))))))).))....)))))))))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)<)))...(((..((.((.......B)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((...(((.((((((((....(((....(((..(.(((..((..(...........)..))))).)..)))..)).)....))))))...(((((((((.(......))))))))))....))))))))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.....A...((.....................................(......).....)).....)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((........}.........].]].]].............)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...((..(.(((....))).....)....((.((((.(.((...)).).))))))......))....))...(((((........)))))]]((((....(((((...(((((((....)))))))..((((....)))...(...((((((...(((((((((((((((((((((((...{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((.)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(..(((.....((((....)))).....))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.(((((((((.(((((.(.(..).).)))))...(((((.....((((..((....(..)....))..............(((((((((())))))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..b.))..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}..)))))..)).))...))))...)))).((((...((((.....a.......))))...))))..)))...).)))))).(((.((...((((....(((.........((((...((((.))))..))))........)))...(((..(((......((..((((........))))...)).....)))..)))..............))))....)).))).(((((.(..(.......)..)....((.(((((((.((.....((((.(..(((((.)))))..)))))....))....)))).))).))..))))).. Structure of rabbit 80S ribosome translating beta-tubulin in complex with tetratricopeptide protein 5 and nascent chain-associated complex; 28S ribosomal RNA 6t59 74 120 3.11 RF00001 URS000002B0D5_9986 31727855 0003735 0005840 9986 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. Structure of rabbit 80S ribosome translating beta-tubulin in complex with tetratricopeptide protein 5 and nascent chain-associated complex; 5S ribosomal RNA 6t59 84 151 3.11 RF00002 URS00004B2C76_9986 31727855 0003735 0005840 9986 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcagguugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<<<<....>>>>.....<.<<<......>>........>>>..>...>>>....<<<..>>><<<<<<<<.......>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]]........)))..)...)))....((....))((((((((.......)))))))).................... Structure of rabbit 80S ribosome translating beta-tubulin in complex with tetratricopeptide protein 5 and nascent chain-associated complex; 5.8S ribosomal RNA 6t7i C2 1771 3.2 RF01960,RF01959,RF00177 URS00005F2C2D_4932 31858614 0003735 0005840 4932 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugagcuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauu ...<<<<<.{.[[[[>>>>><<<<.<<<<<<...<.<..........<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<..<<..<<....<<<..................<<....<<.<<<.....>>>.>>.....>>.........<<<<<..<<....>>..>>>>><.<.<<<<<<......(((((((.<<<....>>>..............>>>>>>.>...>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>..>>>.......>.>.....<<<<<<<.<<<<<....>>>>>.>>>>.>>>......<<..<...........>..>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>>>>>.........<<<[[.....<.<<...<<<.<<....<<<<<<.<<<<<...........>.>>>>.>>>>>>.....<<<<<....................>>>>>....<<<<<.<<.......<<...<.......>..<<<<...>>>>....>>......>>.>>..>>>.........<<<..<<<<<<<<.....))))))).>>>>>>>>.>>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..]]>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..]]]].}<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<.......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>.....>.>>>>>....>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>......<....<<<<<<..........>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<.<<<<..............>>>>.>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>........ ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....))..........((((..((....))..)))).(.(.((((((......[[[.[[[.(.(....).).....(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(((((((.(.(((....))).).)))).)))....(.(((.(...........)).))......)..((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((................))).))))))....((((((....................))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(....(.((.(((.....]].]]]].))).)).)...).....))...(((((((.((...((((..((..((((((.(...((........))......).))))))..)).......((....))...))))..)).))).)))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].].((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....((((((((.......))))))))......))...)))))))))).)...(.(..((.(..((((.((..(.((((((((.(((..(.((..(...((((((..(((................)))..))))))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>....... Structure of yeast 80S ribosome stalled on the CGA-CGA inhibitory codon combination.; 18S ribosomal RNA 6t7i C4 121 3.2 RF00001 URS000055688D_4932 31858614 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<....<<<.<<<............>>>....>>...>>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Structure of yeast 80S ribosome stalled on the CGA-CGA inhibitory codon combination.; 5S ribosomal RNA 6t7i C3 158 3.2 RF00002 URS00001BF64E_4932 31858614 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Structure of yeast 80S ribosome stalled on the CGA-CGA inhibitory codon combination.; 5.8S ribosomal RNA 6t7i C1 3184 3.2 RF02540,RF02543 URS000061F377_4932 31858614 0003735 0005840 4932 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaugguguuuuguauuucacuggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauagagggcuaccuuuauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu .........................<<<<<.....<......>......>>>>>...........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<.<<<<<<<<<<<<<<<<<<<<<.....<<<<......>>>>.(.......<<<......)>>>....>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<.........................<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<....<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>>.>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>..>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<......<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>....>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><<.<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>..>>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<.<.....>..>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<.<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<<<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>.>.>>>>>>>.>>>>.........>>>>>>..........>.>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<....>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.....<<.....<<<<....>>>>.....>>..>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<<<<<<<<<....>>>>>>>.>>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>..>>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<.<..<<<<<......>>>>>..>>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.(((((.......(..............)..(((((((((((((((((((((((.......(((((((......((((((....)))))).......))))))).....))))).))))))))))........(((....)))....)))))))).....))))).))))).<((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))....))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((((((((((....((.(((((((.....(((....(((..(.((((...((((((.....)))))).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((.(.((....((.........))....)).....(...((......)).).).)))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))((((((((((.((......((((.((((....))))))))...)))))))))).)).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........((((..(.....)...))))....))....))...(((((........)))))]]((((.((((.(((...((((....)))...(.[[((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....)))...)))))))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((....)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((((((((((((....))))))).))))))))))....((((.....((((..((((........))))..........]]...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(((.((..)..).)))..)))))...)))....)))).)))))).))))).. Structure of yeast 80S ribosome stalled on the CGA-CGA inhibitory codon combination.; 25S ribosomal RNA 6t7i 5 18 3.2 31858614 4932 aauccuggauggaacgac .................. .................. Structure of yeast 80S ribosome stalled on the CGA-CGA inhibitory codon combination.; mRNA 6t7i 6 76 3.2 RF00005 URS000080E1EA_4932 31858614 0030533 0006412 4932 uuccucguggcccaauggucacggcgucuggcuicgaaccagaagauuccagguucaaguccuggcggggaagcca <<<<<<<..<<<..........>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..(((.....[....))).(((((.......))))).....(((((..]....)))))))))))).... Structure of yeast 80S ribosome stalled on the CGA-CGA inhibitory codon combination.; ICG tRNA Arg 6t7i 7 75 3.2 RF00005 URS0000E60BA3_4932 31858614 0030533 0006412 4932 uccgauauagcguaacggcuaucacaucacgcuuucaccguggagaccgggguucgacuccccguaucggagcca <<<<<<<..<.<..........>.>.<<<<<.......>>>>>....<<<<<.......>>>>>>>>>>>>.... (((((((..(.(.....[....).).(((((.......)))))....(((((..]....)))))))))))).... Structure of yeast 80S ribosome stalled on the CGA-CGA inhibitory codon combination.; tRNA (E-site) 6t7t C2 1771 3.1 RF01960,RF01959,RF00177 URS0001A16A6A_559292 31858614 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugagcuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauu ...<<<<<.{.[[[[>>>>><<<<.<<<<<<...<.<...<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<..<<..<<....<<<..................<<....<<.<<.......>>.>>.....>>.........<<<<<..<<....>>..>>>>><.<.<<<<<<......(((((((.<<<....>>>..............>>>>>>.>...>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>..>>>..>....>.>.....<<<<<<<<<<<<<....>>>>>>>>>>.>>>......<<..<...........>..>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>>>>>.........<<<[[.....<.<<...<<<.<<....<<<<<<.<<<<..............>>>>.>>>>>>.....<<<<<....................>>>>>....<<<<<.<<.......<<...<.......>..<<<<...>>>>....>>......>>.>>..>>>.........<<<..<<<<<<<<.....))))))).>>>>>>>>.>>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..]]>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..]]]].}<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<.......<<........>>..........<<<<<......<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<<<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>...>.>>>>>>>.......>>>>>....>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>......<....<<<<<<..........>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<.<<<<..............>>>>.>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>........ ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[[.[[[.(((....))).....(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(((((((.(.(((....))).).)))).)))....(.(((.(...........)).))......)..((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((.......().......))).))))))....((((((....................))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(....(.((.(((.....]]].]]].))).)).)...).....))...((((.((.((...((((..((..((((((.(...((........))......).))))))..)).......((....))...))))..)).))..)))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].].((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....((((((((.......))))))))......))...)))))))))).)...(.(..((.(..((((.((..(.((((((((.(((..(.((..(...(((((((.((((..............)))).)))))))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>....... Structure of yeast 80S ribosome stalled on poly(A) tract.; 18S rRNA 6t7t C4 121 3.1 RF00001 URS000055688D_559292 31858614 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Structure of yeast 80S ribosome stalled on poly(A) tract.; 5S rRNA 6t7t C3 158 3.1 RF00002 URS00001BF64E_559292 31858614 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Structure of yeast 80S ribosome stalled on poly(A) tract.; 5.8S rRNA 6t7t C1 3184 3.1 RF02540,RF02543 URS0001A16A76_559292 31858614 0003735 0005840 559292 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........................<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..<<<...........<<.<<<<<<...>>>>>>.>>.............<<<<<<.<<<<<<<<<<<<<<<<<<<<<.....<<<<......>>>>.(.......<<<......)>>>....>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<.........................<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<<..>>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<....<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>>.>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>..>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<......<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>....>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<<.....>.>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.....{{<<<<<<...<<<<.<<<<<<<<<<<<<<<<<<..[[[..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>.>.>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<....>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.....<<....<<<<<....>>>>.>...>>..>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<..<<<<<<<<<<<<<<<<<....>>>>>>>.>>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>..........}}...<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))......<<<<<<<..<<<<.))))))>>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>..>>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<...<<<<<<<<<<<]]].>>>>>..>>>>>>..>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<.<..<<<<........>>>>..>>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((.(((...({((((......)))))[[(...).(((....}]])))....))).))))..))))))))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.(((((.......(..............)..(((((((((((((((((((((((.......(((((((......((((((....)))))).......))))))).....))))).))))))))))........(((....)))....)))))))).....))))).))))).<((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))....))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((((((((((....((.(((((((.....(((....(((..(.((((...((((((.....)))))).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))((((((((((.((......((((.((((....))))))))...)))))))))).)).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........(((((((.....).))))))....))....))...(((((........)))))]]((((.((((.(((...((((....)))...(.[[((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....)))...)))))))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((....)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((((((((((((....))))))).))))))))))....((((.....((((..((((........))))..........]]...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((.(((((....{..)))).)))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(((((...)...))))..)))))...)))....)))).)))))).))))).. Structure of yeast 80S ribosome stalled on poly(A) tract.; 25S rRNA 6t7t 5 11 3.1 31858614 559292 aaaaaaaaaaa ........... ........... Structure of yeast 80S ribosome stalled on poly(A) tract.; mRNA 6t7t 7 76 3.1 RF00005 URS000044A311_559292 31858614 0030533 0006412 559292 uccuuguuagcucaguugguagagcguucggcuuuuaaccgaaaugucagggguucgagcccccuaugaggagcca <<<<<<...<<<<........>>>><<<<<<.......>>>>>.>...<<<<<.......>>>>>.>>>>>>.... (((((((..((((....[...))))..((((.......))))......(((((..]....)))))))))))).... Structure of yeast 80S ribosome stalled on poly(A) tract.; tRNA 6t7t 6 76 3.1 RF00005 URS000044A311_559292 31858614 0030533 0006412 559292 uccuuguuagcucaguugguagagcguucggcuuuuaaccgaaaugucagggguucgagcccccuaugaggagcca <<<<<<<..<<<<........>>>><<<<<<.......>>>>>.>...<<<<<.......>>>>>>>>>>>>.... (((((((..((((....[...)))).(((((.......))))).....(((((..]....)))))))))))).... Structure of yeast 80S ribosome stalled on poly(A) tract.; tRNA 6t83 2b 1771 4.0 RF01960,RF01959,RF00177 URS00005F2C2D_4932 31858614 0003735 0005840 4932 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugagcuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauu ...<<<<..{.[[[[.>>>><<<<.<<<<<<...<.<..........<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<..<<..<<....<<<..................<<....<<.<<.......>>.>>.....>>.........<<<<<..<......>..>>>>><...<<<<<<......(((((((.<<......>>..............>>>>>>.....>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>..>>>.......>.>.....<<<<<<<.<<<<<....>>>>>.>>>>.>>>......<<..<...........>..>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>>>>>.........<<<[[.....<.<<...<<<.<<....<<<<<<.<<<<<...........>.>>>>.>>>>>>.....<<<<<....................>>>>>....<<<<<.<<.......<<...<.......>..<<<<...>>>>....>>......>>.>>..>>>.........<<<..<<<<<<<<.....))))))).>>>>>>>>.>>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>.>.>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..]]>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..]]]].}<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<........<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<<<<<<<<....<<<.<<<<......>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>...>.>>>>>>>.....>.>>>>>......>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>......<....<<<<<<..........>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<.<<<<.<<<<....>>>>.>>>>.>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>........ ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..(.....((....((..........))...)){.)......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[[.[[[.(.(....).).....(......).)))))).)...).(.((((.(((((..).)))))))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.(((......)))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(((((((.(.(((....))).).)))).)))....(.(((.(...........)).))......)..((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((....((.((....((((((.(((.......().......))).)))))).....(((((....................)))))....(((((.((.......((..((.......)).(((.....)))....))......)).))..)))..............(.((.(((.....]]].]]].))).)).).........))...((((.((.((...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)).))..)))..)))....)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].].((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.((....(.((((((.(..(((.((.((....))...(.((......)))...)).)))....((((.(((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..))))).)..))).))).....)..)))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....((((((((.......))))))))......))...)))))))))).)...(.(..((.(..((((.((..(.((((((((.(((..(.((..(...(((((((.((((.((((....)))).)))).)))))))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>....... Structure of yeast disome (di-ribosome) stalled on poly(A) tract.; 18S rRNA 6t83 4b 121 4.0 RF00001 URS000055688D_4932 31858614 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<<............>>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......((((...((....))..)))).....))))))))))))))). Structure of yeast disome (di-ribosome) stalled on poly(A) tract.; 5S rRNA 6t83 3b 158 4.0 RF00002 URS00001BF64E_4932 31858614 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Structure of yeast disome (di-ribosome) stalled on poly(A) tract.; 5.8S rRNA 6t83 1b 3184 4.0 RF02540,RF02543 URS000061F377_4932 31858614 0003735 0005840 4932 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........................<<<<<<.....<......>......>>>>>.>...{.....<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<<.<<<<<<<<<<<<<<<<<<<<.....<<<<......>>>>.(.......<<<......)>>>....>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]....}.............................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<.........................<<<<<<<.<<<<<<<<<<<<<<<......<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>...>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<....<<.<<<<<<<.....<<<....<<<..<.<<<<<..<<<<<<.....>>>>>>>>>>>.>..>>>..>>.>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>..>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<......<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>....>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><..<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>...>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<...............>>>>><<.<<<<<<<<<<<....>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.....<<....<<<<<....>>>>.>...>>..>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{.[[[..<<<<<.<<<<<<<<..<<<<<<<<<<<<<<<<<....>>>>>>>.>>>>>>>>>>...<<<<<.....<<<<..<<<<........>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]...}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>..>>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<.<<<.<<<....<<<<.<..<<<<<......>>>>>..>>>>>...>>>....>>>..>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........(((((((.((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.(((((.......(..............)..(((((((((((((.(((((((((.......(((((((......((((((....)))))).......))))))).....))))).)))).)))))........(((....)))....)))))))).....))))).))))).<((((........))))((((((..(.(((((..((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....))))))..)))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))....))))))))).(..(.......)....)..))))))......).))).((((((....(.(((....))).)((((((((((....((.(((((((.....(((....(((..(.((((...((((((.....)))))).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))((((((((((.((......((((.((((....))))))))...)))))))))).)).....))))))((.....((.....((((((.......))))))((((.....((((..((...((.((....((.....))..)).))....[[(((.((...((....(((....)))........(((((((.....).))))))....))....))...(((((........)))))]]((((..(((.(((...((((....)))...(.[[((((((...((((.(.((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))).).))))(...)....))))))...))....)))...))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((....)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((((((((((((....))))))).))))))))))....((((.....((((..((((........))))..........]]...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))).)..(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Structure of yeast disome (di-ribosome) stalled on poly(A) tract.; 25S rRNA 6t83 6b 76 4.0 RF00005 URS000044A311_4932 31858614 0030533 0006412 4932 uccuuguuagcucaguugguagagcguucggcuuuuaaccgaaaugucagggguucgagcccccuaugaggagcca <<<<<<...<<<<........>>>><<<<<<.......>>>>>.>...<<<<<.......>>>>>.>>>>>>.... (((((((..((((....[...)))).(((((.......))))).....(((((..]....)))))))))))).... Structure of yeast disome (di-ribosome) stalled on poly(A) tract.; tRNA 6t83 a 1758 4.0 RF01960,RF01959,RF00177 URS00005F2C2D_4932 31858614 0003735 0005840 4932 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<...[[[[>>>>>[[[..((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[..................<<....<<.<<.......>>.>>.....>>.........<<<<<..<<....>>..>>>>>[...((((((......<<<<<<<<<<<<..>>>>..............)))))).....]...<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<<<<<<.<......>.>>>>>>>.>>>......<<..<...........>..>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..)))))).]]].........[[[{{.......{{...[[[.{{....<<<<<<.<<<<<....<.>.....>>>>>.>>>>>>....<<<<<<...........<.......>...........>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[[..(((((((.....>>>>>>>>..))))))).]]].....}}....<<<<<<.<<...<<<<..<<<.<<<<<<.<...<<<......>>>......>.>>>>>>.>>>.......<<....>>...>>>>..>.>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<..........>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<<<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>...>.>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>......<....<<<<<<..........>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<...>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[[[[[[[(((....))).....(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....((..(.(((...(....)...))).)...))......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((((....(())....))))).))))))....((((((.....(...(..(.....)..)...).....))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(....(.((.(((....]]]]]]]].))).)).)...).....))...(((..((..(...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)..))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((........((.(((........))).))......)))))...((.(((...(..(((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))......).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...(((((...)))))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>........ Structure of yeast disome (di-ribosome) stalled on poly(A) tract.; 18S rRNA 6t83 Aa 3127 4.0 RF02540,RF02543 URS000061F377_4932 31858614 0003735 0005840 4932 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........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[...<.......<<.<<<<<<...>>>>>>.>>.......>.....<<<<<<<.<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<......<<<<<<<.<<<<<<<<<<<<<<<......<<<<<<<<......<<<<<......>>>>>.......>>>>>>>.>...>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.........>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<......<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>....>>>>>>.>>>>..>>>>>>><<<<<<<<<......>>>>>>>>>....>>>>>><<<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>.>>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<....>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>>....<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>.....<<<<<<<<....>>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<..>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<.........>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{.[[[..<<<<<.<<<<<<<<..<<<<<<<...>>>>>>>...<<<<<.....<<<<..<<<..........>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]...}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.........<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.<.....>.>>>.....>>>>>..>...>>>.......<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>....<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<.<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>..>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((.(((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))).....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.(((((......(((((((((((((((((((((((.......(((((((......((((((....)))))).......))))))).....))))).))))))))))........(((....)))....)))))))).....))))).))))).<((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((....((((((....))))))....)<)))...(((..((.((.......A)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((....((.(((((((.....(((....(((..(.((((...(.((((.....)))).).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.......(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((......)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((..((((((....((.....))..)))))....[[(((.((...((....(((....)))........((((....))))....))....))...(((((........)))))]]((((..(((((((...((((....)))...(.[[((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).))).))).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((..)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.....((.....((((....)))).....))..))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.((((((((..((((((.....))))))....((((.....((((..(((..........)))..........]]...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))((......)).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......(..(.(.((((((...((.......))...))))).)..))...)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((.(.............).))...)))).))))....))))))))....((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Structure of yeast disome (di-ribosome) stalled on poly(A) tract.; 25S rRNA 6t83 Bb 121 4.0 RF00001 URS000055688D_4932 31858614 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<....<<<.<<..............>>....>>...>>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))..((((.......(((((..((....)).))))).....))))..))))))))). Structure of yeast disome (di-ribosome) stalled on poly(A) tract.; 5S rRNA 6t83 Ca 157 4.0 RF00002 URS00001BF64E_4932 31858614 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>.................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....))))))))).................... Structure of yeast disome (di-ribosome) stalled on poly(A) tract.; 5.8S rRNA 6t83 8 76 4.0 RF00005 URS000044A311_4932 31858614 0030533 0006412 4932 uccuuguuagcucaguugguagagcguucggcuuuuaaccgaaaugucagggguucgagcccccuaugaggagcca <<<<<<...<<<<........>>>><<<<<<.......>>>>>.>...<<<<<.......>>>>>.>>>>>>.... (((((((..((((....[...)))).(((((.......))))).....(((((..]....)))))))))))).... Structure of yeast disome (di-ribosome) stalled on poly(A) tract.; tRNA 6tb3 2 1771 2.8 RF01960,RF01959,RF00177 URS0001A16A88_559292 32299921 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugagcuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauu ...<<<<<.{.[[[[>>>>><<<<.<<<<<<...<.<...<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<..<<..<<....<<<..................<<....<<.<<<.....>>>.>>.....>>.........<<<<<..<<....>>..>>>>><.<.<<<<<<......(((((((.<<<....>>>..............>>>>>>.>...>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>..>>>..>....>.>.....<<<<<<<<<<<<<....>>>>>>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>>.........<<<[[.....<.<<...<<<.<<....<<<<<<.<<<<..............>>>>.>>>>>>....<<<<<<....................>>>>>>...<<<<<.<<.......<<...<.......>..<<<<...>>>>....>>......>>.>>..>>>.........<<<..<<<<<<<<.....))))))).>>>>>>>>.>>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..]]>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..]]]].}<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<......<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<<<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>...>.>>>>>>>.......>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>......<....<<<<<<..........>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<.<<<<.<<<<....>>>>.>>>>.>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>........ ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[[.[[[.(((....))).....(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(((((((.(.(((....))).).)))).)))....(.(((.(...........)).))......)..((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((................))).)))))).....(((((....................)))))....(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(....(.((.(((.....]].]]]].))).)).)...).....))...((((.((.((...((((..(((.((((((.(...((........))......).)))))).))).......((....))...))))..)).))..)))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].].((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((.(..(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..))))).)..))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....((((((((.......))))))))......))...)))))))))).)...(.(..((.(..((((.((..(..(((((((.(((..(.((..(...((((((..((((.((((....)))).))))..))))))...)..)).)..))).))))))).)..)).))))...).))...)..)..(((((((((....)))))))))>....... yeast 80S ribosome in complex with the Not5 subunit of the CCR4-NOT complex; Saccharomyces cerevisiae S288C 18S ribosomal RNA (RDN18-1), rRNA 6tb3 n 75 2.8 RF00005 URS00002CB170_559292 32299921 0030533 0006412 559292 agcgccgunncgcagnggaagcgcncagggcucaunacccugaunnncucggaucgnaaccgagcggcgcuacca <<<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((....[..)))).(((((.......))))).....(((((..]....)))))))))))).... yeast 80S ribosome in complex with the Not5 subunit of the CCR4-NOT complex; tRNA 6tb3 BQ 3223 2.8 RF02540,RF02543 URS0001A16A8B_559292 32299921 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaugguguuuuguauuucacuggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauagaggguguagaauaagugggagcuucggcgccagugaaauaccacuaccuuuauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<<....>>......>>>>>.>...<.....<<....>>..<<<<<......<<.....>>.....>>>>>..<<<...<.......<<.<<<<<<...>>>>>>.>>.......>.....<<<<<<.<<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>....>.............................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<.........................<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<....<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>..>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<.<.....>..>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<.<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<<<<<<<<<<<<..[[[..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>.>.>>>>>>>.>>>>.........>>>>>>..........>.>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<.<<<<<<<<<<<....>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.....<<.....<<<<....>>>>.....>>..>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<..<<<<<<<<<<.<<.<<.<..........<.<<......................>>.>..>>>.>>..>>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))......<<<<<<<..<<<<.))))))>>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>..>>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<....<<<<<<<<<<]]].>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<.<..<<<<<......>>>>>..>>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.(((((.......(..............)..(((((((((((((((((((((((.......(((((((......((((((....)))))).......))))))).....))))).))))))))))........(((....)))....)))))))).....))))).))))).<((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))....))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((((((((((....((.(((((((.....(((....(((..(.((((...((((((.....)))))).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........(((((.(.....)..)))))....))....))...(((((........)))))]]((((.((((.(((...((((....)))...(.[[((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....)))...)))))))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((....)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.((((((((..((((((((((....(.((..........(..(..(.(...))............)..)..))).....))))))))))....((((.....((((..((((........))))..........]]...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. yeast 80S ribosome in complex with the Not5 subunit of the CCR4-NOT complex; 25S rRNA 6tb3 BR 121 2.8 RF00001 URS000055688D_559292 32299921 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). yeast 80S ribosome in complex with the Not5 subunit of the CCR4-NOT complex; 5S rRNA 6tb3 BS 158 2.8 RF00002 URS00001BF64E_559292 32299921 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... yeast 80S ribosome in complex with the Not5 subunit of the CCR4-NOT complex; 5.8S rRNA 6tbv 16S1 1534 2.7 RF00177,RF01959,RF01960 URS000081169C_83333 32094585 0003735 0005840 83333 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<<....>>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<<..>>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>...<.<<<<<......<<<.<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<....<.<<<....>>>>......<......>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((((((((..)))))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((.(...(...((.((((((.......)))))))).....)....).)))....)).(((.([[[...(((((.....((.]]])).......)))))).)))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((....((.((....)).))......(....)...))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Cryo-EM structure of an Escherichia coli ribosome-SpeFL complex stalled in response to L-ornithine (Replicate 2); 16S rRNA 6tbv 23S1 2897 2.7 RF02540,RF02541 URS0000A7632D_83333 32094585 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<....<.<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>..>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<.....>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<<..<<<<.......>>>>..>>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<......>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<<.<<....>>..>>>>>>.>.....>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>.............>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((((.....)).))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(...((......)).).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((((......))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((((.((((.(.((.(..........(.(...(((......((((((((....))))))))...))).............).).).)).).)))).))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).).....((.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..))....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Cryo-EM structure of an Escherichia coli ribosome-SpeFL complex stalled in response to L-ornithine (Replicate 2); 23S rRNA 6tbv 05S1 120 2.7 RF00001 URS0000049E57_83333 32094585 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Cryo-EM structure of an Escherichia coli ribosome-SpeFL complex stalled in response to L-ornithine (Replicate 2); 5S rRNA 6tbv PTR1 76 2.7 RF00005 URS0001A16A6E_83333 32094585 0030533 0006412 83333 gcauccgnagcucagcuggauagaguacucggnuicgnaccgagcgncggaggnucgaauccucccggaugcacca <<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.........)))).(((((.......)))))....(((((.......)))))))))))).... Cryo-EM structure of an Escherichia coli ribosome-SpeFL complex stalled in response to L-ornithine (Replicate 2); P-site Arg-tRNA 6tc3 16S1 1534 2.7 RF00177,RF01959,RF01960 URS000081169C_83333 32094585 0003735 0005840 83333 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<<....>>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<<..>>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<<<.<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<....<.<<<....>>>>......<......>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((((((((..)))))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((.(...(...((.((((((.......)))))))).....)....).)))....)).(((.([[[...(((((.....((.]]])).......)))))).)))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((....((.((....)).))......(....)...))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Cryo-EM structure of an Escherichia coli ribosome-SpeFL complex stalled in response to L-ornithine (Replicate 1); 16S rRNA 6tc3 23S1 2897 2.7 RF02540,RF02541 URS0000A7632D_83333 32094585 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<....<.<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>..>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<.....>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<<..<<<<.......>>>>..>>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<......>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<<.<<....>>..>>>>>>.>......>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((((.....)).))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(...((......)).).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((((......))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((((.((((.((((.(..........(.(...(((......((((((((....))))))))...))).............).).).)))).)))).))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).).....((.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..))....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Cryo-EM structure of an Escherichia coli ribosome-SpeFL complex stalled in response to L-ornithine (Replicate 1); 23S rRNA 6tc3 05S1 120 2.7 RF00001 URS0000049E57_83333 32094585 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Cryo-EM structure of an Escherichia coli ribosome-SpeFL complex stalled in response to L-ornithine (Replicate 1); 5S rRNA 6tc3 PTR1 76 2.7 RF00005 URS0001A16A6E_83333 32094585 0030533 0006412 83333 gcauccgnagcucagcuggauagaguacucggnuicgnaccgagcgncggaggnucgaauccucccggaugcacca <<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.........)))).(((((.......)))))....(((((.......)))))))))))).... Cryo-EM structure of an Escherichia coli ribosome-SpeFL complex stalled in response to L-ornithine (Replicate 1); P-site Arg-tRNA 6th6 Aa 1463 2.55 RF00177,RF01959,RF01960 URS00021ED914_69014 32555463 0003735 0005840 69014 auucnggnugauccugccggaggccacugcuauggggguccgacuaagccaugcgagucauggggcgcgcgcgcgcaccggcggacggcucaguaacacgucgguaaccuacccucgggagggggauaaccccgggaaacuggggcuaaucccccauaggccugagguacuggaagguccucaggccgaaaggggcaugcccgcccgaggaugggccggcggccgauuagguaguuggugggguaacggcccaccaagccgaagaucgguacgggccaugagagugggagcccggagauggacacugagacacggguccaggcccuacggggcgcagcaggcgcganaccuccgcaaugcgggcaaccgcgacggggggacccccagugccguggcagccacggcuuuuccggaguguaaaaagcuccgggaauaaggncugngcaaggcngguggcagccgccgcgguaauaccggcggcccgaguggungccgcuauuauugggccuaaagcguccguanccgggcccguaagucccungcgaaaucccacggcucaaccguggggcuugcuggggauacugcgggccuugggaccgggagaggccggggguaccccugggguaggggugaaauccuauaaucccaggnngaccgccaguggngaaggcgcccggcuggaacggguccgacggugagggacgaaggccaggggagcgaacnggauuagauacccggguaguccuggcuguaaaggaugcgggcuaggugucgggcgagcuucgagcucgcccggugccggagggaagccguuaagcccgccgccuggggaguacggccgcaangnugaaacuuaaaggaauuggcgggggagcacuacaagggguggagcgugcgguuuaauungaunnaacgccgggaaccucaccgggggcgacggcaaggccaggcugaaggucuugccggcgagaggaggugcauggccgccgucagcucguaccgugaggcguccacuuaagugugguaacgagcgagacccgcgcccccaguugccaguccuccccgcuggggaggaggcacucuggggggaccgccggcgauaagccggaggaaggagcgggcgacgguaggucaguaugccccgaaacccccgggcuacacgcgcgcuacaaugggcgggacaaugggauccgaccccgaaaggggaagggaauccccuaaacccgcccucaguucggaucgcgggcugcaacucgcccgcgugaagcuggaaucccuaguacccgcgugucaucaucgcgcggcgaauacgucccugcuccuugcacacacngnccgucacuccacccgagcgggguccgggugaggccuggucucccuucggggaggccgggucgagccugggcuccgugaggggggagaagucguancaagguagcnguaggggnnccuacggcucgauc ...<<<<<.[.((((>>>>>.<<<<<<<<<..<<<<<<.<<......<<<.<<<..<<<..<<.<<<<<..>>>>>.>>>>>......<<........<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<<<<<.<<......>>>>>>>>>>>.....<<<<..>>>>.>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<............>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<<<<<.>>>>>>>>...<<<<<<<<.......>>>>>>>>.....<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<....<<<<<<<<.....>>>>>>>>...>>>>>>>>..>>>>>>>>>...<<<<<<.....<<<<<<<<<..<<<<<<<<<..<<<......>>>.....>>>>>>>>>..>>.......<<....>>.>>>>>>>....>>>.>>>...>>>...>>>>...<<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>>.........<<<<<<..<<<<<<<<<<<<<<.....>>>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<...<<....<<<.<<<.......>>>.>>>..>>...<<.<<<..<<<<<<<<<....<<<<<<.<<....>>...<<<<......>>>>..>>>>>>....<<<<<.<<<<<<<..<<<..<<<<<<<<...>>>>>>>>>>>...>>>>>>>.....<<<<<.....>>>>>........>>>>>....>>>.>>>...>>>>>>>>....>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>.....<<<<<<<.......>>>>>>>.......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<..<<<<<<<<<<<<<....>>>>>>>>>>>>>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... ...((((..[.[[[..)))).(((((((((..((((((.(((.....(((.(((..(((..((.(((((()))))).)))))......(((.......(((((((..((...(((((((.(((((....((((((....)))))).....)))))...(((((((((.((......))))))))))).....((((..)))).)))))))..))))))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((((((.))))))))....(((((((.......)))))))......((((([[....(.((((.....((..]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((.....(((((((.....)))))))....))))))))..)))))))))..(((((((.....(((((((((..((((((((...((........))......))))))))..)).......((....)).)))))))....))).)))..))))...))))...(((((((...((...((((.........))))...))))))))).....{...((((((..((((((((((((((.....))))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..((((((((((......((........))..........(((((((.....(...(((.((((.....)))).)))..)....((.(((...(.((((((....((((((.((....))...((((......))))..))))))....(((((.(((((((..(((..((((((((...)))))))))))...)))))))..(..(((((.....))))).....)..)))))....))).)))....).)))))....)))))))...)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..)))))......(((((((.......))))))).......))...)))))))))).))..(.(..((.(.((((.(((...(((((((((((...(((((((((((((....)))))))))))))...)))))))))))...))).))))..).))...)..)..(((((((((....)))))))))}.... Cryo-EM Structure of T. kodakarensis 70S ribosome; 16S ribosomal RNA 6th6 BA 2934 2.55 RF02540,RF00002 URS00021ED96D_69014 32555463 0003735 0005840 69014 cccgguggcaacuaagccgccugguggauggcucggcucggggcgccgacgnangncguggcaagcugcgauaagccccggcgaggcgcaggcagccgucgaaccggggaugcccgaaugggaccucccgcggcuugccgcacucccagucgggagggggaacgcggggaauugaaacaucuuaguacccgcaggaaaagaaancaaaagcgaugccguuaguaggggcgaccgaaagcggcacagggcaaacugaaccccgggccgaaagguucgggggaugugguguuguagggcccgcggaggagcccugggggcgaagccgaagucngcuggaacgcggcgccggagagggugaaagccccguaggcguaagcccccgagcuccugcggugucccugaguaccgucggucggauauccggcgggaagcugggaggcancggcucccaacccuaaauacgucncgagaccgauagcnaacuaguacngugngggaaagcugaaaagcaccccgggaggggggugaaaagagccugaaaccaggcggcgauaggagggugcggcccgaaaggguugacccuccccgaaggaaacacgggcgaccguggaguacgaggggaggugaccgggguugcaccguccgncuuggaucacngggcanggaguucacccgagcggcgagguuaagggggucaaccccgaagccgcagggaaaccgacagguccgcagcccguagggcgagggacggggugugaaagcgcccggagucgcucgggugagacccnaagccggucgaucuagcccggggcagggugaanucccucaacagagggnuggaggcccgcuaggggugnugncgngcanuucgcucccgugaccccgggcuaggggugaaangccaaucgaggccggcgaungcugguucccnccgaauuaucccccaggauagcccggccggagguaggcagugggguagagcacugauuggggguuuagggggcgaaagccuccggcucccugucaaacuccgaacccacugccgccguagauggccggaguaggggggcgguguaagccgucacccgagaggggancaacccagaccgggguuaangccccaaagugccggcuaaguguuacuccaaagggugucccuggccuuagacagcggcccgucgaggucaggggccccgaaaauggacggggcuuaagccggccgccgagaccccggcgcacggaccgauugguccgugaucggguaggcgggcgugccgauggggcggaagccgggccgugagguccgguggacccgucgguauugcggauccugccgggaguagcagcauagccgggugagaaucccggccgccguaggggccaggguuccacggcaauguucgucagccguggguuagucgguccuaacccgacccguaacucggcgucggggaaagggaaacggguuuauauucccguaccgcggugguaggugcggcaacgcaagcccgaggggugacgccucgggguaggcggaccgguccacaaggccggcuaagcgnauaagcccggggagugccguaauggcgagaaccgggugaaagcgcgaauggccucccguaagggggguuccgccgaucccuggggnccgugaaaagcnccucgggaacgauccaccgcgaccguaccgagaaccgacacuggugccccugggngagaagccuaaggcgugucgggggaaacccagccgagggaacunggcaaauuggccccguaacuucgggagaaggggugccugcggguguguaacccgcaggucgcagugacuaggggggcccgacugnuuaguaaaaacacaggucccagcuagcccgaaaggguuunuacngggnccgacgccugcncagngccgguaugugaagcccggguacaaccgggugaagcaccgnuaaacngcggggguaacuauaacccucuuaagguagngaaauucnuugucgguuaaaugccgacnugcaugaauggcguaacgagguccccacuguccccggcungggcncggcgaaaccucugccaggcgcaunugccugggaccuccggugggaagcgaagaccccauggagcuuuacugcagccugccguugccguacggcggggggugcgcagcguaggcgggaggcgucgaagcccgcccuccggggcggguggagccgcccaugagacaccgcccacccucugccguacggcuaacccgcggaagcggggacagcgguaggugggcaguuuggcugnggcggcacacccucgaaaagguaucnagggugcccuaaggucggcucaggcgggucaggaauccgccguagagugcaagggcaaaagccggccugacuggacccguaacagaggcggguccagccgcgaaagcguggccuagcgaaccccugugccuccccggugggggccaggnaugacagaaaagcnacncuggnganaacagagucgucucgggcgagagcccauaucgaccccgaggcuugcuaccucgcugucgncucuucccauccuggcccugcagcaggggccaagggugggggnguucacccauuaaagnggaacgugagcuggguuuagaccgucgugagacaggucggaugcuaucuaccggagguguuggccgccugagnggaaggcucccccaguacgagaggaacagggagccgcggcnucuggucuaccgguuguccuacagggcauagccgggcagcuacgccgcagccgauaaggccugaaagcaucuaaggccgaagcggccccngaaaacaggcggccaccgagggcccgggaagaagacccgguugauggggcggggauguaagcgggaagggaaaccgacccguucagucugccgcucccaacagcccgagugcuaccggg <.<<<<<<<<.....<<<<<<<<<<.....<<..<<<<<<<.[<<<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<....>>><<<<<..>>>>>.<<<<<....>>>>>.>>....<<<<<.....<......>......>>>>>...........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<...<<<...<<<<<<<<<....>>>>>>>>>.....>>>.....<<<<.<<<<....<<<<..<<<<<<<...<<<.....<<<<......>>>>.((......<<<.....))>>>...>>>....>>>>>>>.>>>>..>>>>...>>>>.....<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......>>.]>>>>>.>>...............<<....>>....>>.........<<<<....>>>>.................>>>>>>>>>>........<<<<<<<<<<....<<....<.<<<<<<<...<....<<<<<....>>>>>.....>..>>>>>>>>..>>.>>>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.....<<<<...<<<<...>>>>...>>>>.<<<<<<....>>>>>>...>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<..<<<.<<<<<<<<<...<<<...<<<<.<<<<<<....<<<<.......>>>>.>>>>>>.>>>>..>>.>...>>>>>>>>>>>>.....>>>>>>>.>>..<<<<<<<<<....>>>>>>.>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<.........<<<.<<<<<<<<<<.........<..>......>>>>>>>>>>>>>..........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<<<<....>>>>>>>>..>>....>>>>>><<<<<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>>>.>>.....>>>>>><<.....<<......<<<<<<.......>>>>>><<<<....<<<...<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<<<<.....>>>.>>>>>>....>>...<<<<<........>>>>>))<<<<<<<<.....<<<....>>>...<<<<<<<<<<...<<<<<<<<<..<<<<<<<<<<<<....{>>>>>>....<<<<.<..<<<<<<.....<<<<...>>>>.....>>>>>>...>>>>>.....<<<<<<......>>>>>>>>>>>>...>>>>>>>>>.........>>>>>>>>>>......>>>>>>>>>>>>..>>.....<<......>>...>>>.<<<<.....>>>>..>>>>...<<<<.....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<.....>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<....>>>>......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<<<<<......>>>>>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>....>>....<<<<<........>>>>>..<<<<<<<<.<<<.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<<.<<<<<<<<<<<..<<<<..........<<<<<..<<<......<<<<<<.<<...>>>>>>>>...>>>............>>>>>.>.>>>.>>>>>>>>>>>...<<<<<....>>>>>....>>>>>>>>>..>>>>>.....<.....>....<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<<.......>>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>..<<<.......>>>......>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..>>>>>>>>>>>....<<<<<<<<..<<<<..<<<<<<<.................>>>>>>><<<<<...<<<<...<<<<<<<<<<}...>>>>>..>>>>>...>>>>.>>>>>.<<<<.<..<<<<<...........>>>>>...>>>>>>>>>>......>>>>>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<<<<<....<<<<<..<<....>>..>>>>>...>>>>.>>>>>.>>>...>>>>...>>>>>>>>.> ((((((.(((.....(((((((((.....(((..(((((((.(((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))(((((..))))).(((((....))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((..((((((((((....)))))))))....)))....(.(((((((((....((((.(.((((((...(((...({((((......)))))[[(...).(((....}]])))...)))....))))))).))))..)))).).))))]....(((((((........)))))))....).(((((.[[[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))...........)).....)))))))))......(.((((((((((....((......(((((((...(....(((((....))))).....)..)))))))...)).)))))))))).[((((........))))((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))..(..((((...((((...))))...)))))((((((....))))))...)))))))))))))..((.(...((((.(.....((((((((((.((((...(((((((....)))))))...)[)))....(((..((.((........)))).)))..).))))))))).(.(((.....)))...)..).))))......).))).((((((....(((((....))))).(((((((...(((.(((((((((...(((...((((.((((((....((.(.......).)).)))))).))))..)).)...))))))))))))......)))))).)...(((((((((....)))))).)))....(((......)))...(((((((...((([[[...(.((((((.....((.........(((.((((((((((........((()).)....)))))))))))))..........]]]))....))))))))))...)))))))((((((((((....))))))))..))....))))))((((((((((((......((((((((....))))))))...)))))))))).)).....))))))((.....((......((((((.......))))))((((....(((...((..(((((((...((.....)).))))))....[[((((((...(((((((((.....))).))))))....))...(((((........)))))]]((((((((..(..(((....)))...((((((((((...(((((((((..((((((((((((....{))))))(...((((....((((((.....(((.....))).....))))))....))))....)((((((......))))))))))))...)))))))))(...)....))))))))))..)...)))))))))))).))).....((......))...))).((((.....))))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((.....))))))))))(...).......(((((((((.].((.........))...(((((((....((((....))))......))))))).}((((.(((..((((((((..((...((((((......))))))...))))))))..)))))(..((.........))..)........((..........((((((.....))))))..)..)....))))...)).))))))).)..))).)))))))).))))))....))){..(((((.....].})))))..((((((((.(((.((......((((.((((((..(((((.(((((((((.((((((((((..(.((.(.........(((((..(((........(((.((.....))))).....)))............))))))..)).).))))))))))...(((((....)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.(((((.........)))))...)..(][.[[[).....))))))).(.((((((((((.......)))))))))))(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....).....))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))..(((.......)))......)))))..)...))).))....(((((((....))).))))....))..)))))))))))....(((((((...((((..(((((((......(....).....)))))))(((((...((((...((((((((((}...)))))..))))).[.)))).))))).((((....((((.............))))....)))))))).......)))))))..(..(((((((((.......)))))....((((((((((((....(((((..((....))..)))))...))))]))))).)))...))))..)))).)))))) Cryo-EM Structure of T. kodakarensis 70S ribosome; 23S ribosomal RNA 6th6 BB 125 2.55 RF00001 URS000037D4EC_69014 32555463 0003735 0005840 69014 gguacggcggccauagcggcggggccacacccggucucguuucgaccccggaaguuaagcccgccagcguucccggguguacugcccuccgagagggggcgggaaaccgggaacgccgccggcca <<<.<<<<<<<....<<<<<<<<.....<<<<<<.............>>>>..>>....>>>>>>.>>.<<<<<<<.....<<<<<<.<<....>>>>>>>>....>>>>>>>.>>>>>>>>>>. (((.(((((((....((((((((.....((((((...(.....)...))))..))....)))))).))..((((((.....((((((.((....))))))))....))))))..)))))))))). Cryo-EM Structure of T. kodakarensis 70S ribosome; 5S ribosomal RNA 6tnn U 2930 3.07 RF02540,RF02541,RF00002 URS0000AB488E_224308 32991829 0003735 0005840 224308 acgguuaaguuagaaagggcgcacgguggaugccuuggcacuaggagccgaugaaggacgggacgaacaccgauaugcuucggggagcuguaagcaagcuuugauccggagauuuccgaauggggaaacccaccacucguaauggagugguauccauaucugaauucauaggauaugagaaggcagacccggggaacugaaacaucuaaguacccggaggaagagaaagcaaaugcgauucccugaguagcggcgagcgaaacgggaucagcccaaaccaagaggcuugccucuugggguuguaggacacucuguacggaguuacaaaggaacgagguagaugaagaggucuggaaaggcccgccauaggagguaacagcccuguagucaaaacuucguucucuccugaguggauccugaguacggcggaacacgugaaauuccgucggaauccgggaggaccaucucccaaggcuaaauacucccuagugaccgauagugaaccaguaccgugagggaaaggugaaaagcaccccggaaggggagugaaagagauccugaaaccgugugccuacaaguagucagagcccguuaacgggugauggcgugccuuuuguagaaugaaccggcgaguuacgaucccgugcaagguuaagcagaagaugcggagccgcagcgaaagcgagucugaauagggcgcaugaguacguggucguagacccgaaaccaggugaucuacccauguccagggugaaguucagguaacacugaauggaggcccgaacccacgcacguugaaaagugcggggaugagguguggguaggggugaaaugccaaucgaaccuggagauagcugguucucuccgaaauagcuuuagggcuagccucaagguaagagucuuggagguagagcacugauuggacuaggggccccuaccggguuaccgaauucagucaaacuccgaaugccaaugacuuauccuugggagucagacugcgagugauaagauccguagucgaaagggaaacagcccagaccgccagcuaaggucccaaaguauacguuaaguggaaaaggauguggaguugcuuagacaaccaggauguuggcuuagaagcagccaccauuuaaagagugcguaauagcucacuggucgagugacucugcgccgaaaauguaccggggcuaaacguaucaccgaagcugcggacuguucuucgaacagugguaggagagcguucuaagggcugugaagccagaccggaaggacugguggagcgcuuagaagugagaaugccgguaugaguagcgaaagaggggugagaauccccuccaccgaaugccuaagguuuccugaggaaggcucguccgcucaggguuagucgggaccuaagccgaggccgaaaggcguaggcgauggacaacagguugauauuccuguaccaccuccucaccauuugagcaauggggggacgcaggaggauaggguaagcgcgguauuggauauccgcguccaagcaguuaggcugggaaauaggcaaauccguuucccauaaggcugagcugugauggcgagcgaaauauaguagcgaaguuccugauuccacacugccaagaaaagccucuagcgaggugagaggugcccguaccgcaaaccgacacagguaggcgaggagagaauccuaaggugaucgagagaacucucguuaaggaacucggcaaaaugaccccguaacuucgggagaaggggugcucuguuagggugcaagcccgagagagccgcagugaauaggcccaggcgacuguuuagcaaaaacacaggucucugcgaagccguaaggcgaaguauaggggcugacgccugcccggugcuggaagguuaagaggagcgcuuagcguaagcgaaggugcgaauugaagccccaguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgacccgcacgaaaggcgcaacgaucugggcacugucucaacgagagacucggugaaauuauaguaccugugaagaugcagguuacccgcgacaggacggaaagaccccguggagcuuuacugcagccugauauugaauguugguacagcuuguacaggauagguaggagccuuggaaaccggagcgccagcuuugguggaggcaucggugggauacuacccuggcuguauugaccuucuaacccgccgcccuuaucgggcggggagacagugucaggugggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguucccucagaaugguuggaaaucauucgcagaguguaaaggcacaagggagcuugacugcgagaccuacaagucgagcagggacgaaagucgggcuuagugauccggugguuccgcauggaagggccaucgcucaacggauaaaagcuaccccggggauaacaggcuuaucucccccaagaguccacaucgacggggagguuuggcaccucgaugucggcucaucgcauccuggggcuguagucggucccaaggguugggcuguucgcccauuaaagcgguacgcgagcuggguucagaacgucgugagacaguucggucccuauccgucgcgggcgcaggaaauuugagaggagcuguccuuaguacgagaggaccgggauggacgcaccgcugguguaccaguuguucugccaagggcaucgcuggguagcuaugugcggacgggauaagugcugaaagcaucuaagcaugaagccccccucaagaugagauuucccauuccgcaaggaaguaagaucccugaaagaugaucagguugauaggucugagguggaaguguggcgacacauggagcugacagauacuaaucgaucgaggacuuaaccau ..<<<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<.....((.>>>.....<<<<<<<..<<.))......>>.....>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<<<<<<<<.........>>>>>>>.>>.>>....<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<......<<.....>>.....>>>>...(((....<<<<<<<<....>>>>>>>>......<<<<<<<<<.....<<<<.......<<<<<<<<<<.<<<.....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>.>>>>>..>>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<......>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<.<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>......>>>>>.>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<...<<<<<<<<<.....<<<...<<<<<<<<......<<<<.....>>>>.......>>>>>>>>..>>.>.....>>>>.>>>>>..>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<.....................>>.........<<......>>...>>>>>....>>>>>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<...>>>>>>>....>>>>>><.<<<<<<<.<<......<<<<<.<<....>>.>>>>>...>>.>>>>>>>..>.....>>>>>><......<<....<<<<<<.......>>>>>><<<<....<<<<<.<<<..<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<.<<<<<<......<<...<<<<....<<<<..<<<..<<<.<.<<<.<.....{....>.>>>.<<..<......<<.<.<<<<<<<.<<.....>>>>>>>>>.....>>>......>...>><..<<...........>>...>>.>>>...>>>...>>>>.........>>>>..>>..>>>>>>>>>>>>>>>.>>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<<........<.....<<<<<....<<..>>.....>>>>><<<<<....<<<<....>>>>...>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>..<<<<.<<<..<<<<<<<..<<<...<<...<<<<<..<<....>>...>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>...>>.>>>>>>>..>.>>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<<.<<<.<<<..<<<<<<............<<<<<..<<...............................>>............>>>>>..>.>>>>>..>>>.>>>....<<.<<<<<.......>>>>>>>.....>>>>>>>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.}..>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>>>.. (.((((((((......((((((((((.....(((..(((((((((((((......((((((.....[[[)))...].((((((...(((]].....)))......))))))...)))....(((....)))(((((((......))))))).(((((((((.........))))))).)).))....((((((.....(...[..)......))))).).........((....))...((((......((.]...)).....))))...((((...((((((((....))))))))....{.(((((((((.....((((.......((((((((((.(((...(.((((......)))))[[(...).(((.....]])))...)))...)))))))))))))).)))))..)))))....((((((((..[......))))))))....}.(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((..((((..[...))))..)))).<.(.(........).).((((((....(((((((.(((((..(((...(((.....)))...)))...((....))..((((.....))))......))))).)))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)<)))...(((.(((((.......A))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((...(((((((((.....(((...((((((((.......(((.....)))........))))))))..)).).....)))).)))))..))))))).))..(((((((.((......)).)))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((((.((.....{.(((((......((...........))..........(...((......)).).)))))...)).))))))).))...........]]].)...))))))))))...)))))))(((((((...)))))))....))))))(.(((((...((......(((((.((....))])))))...))...)))))..).....))))))(......((....((((((.......))))))((((....(((...((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((.(((((.......((...((((....((((..(((..(((.(.(((.......{......))).((.........((.(.(((((((.((.....))))))))).....)))..........))(..((...........))...)).)))...)))...))))(..).....))))..))...)))))))))))))).))).....((......))..))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.[..).....)))))(((((....((((....))))...)))))(...).......(((((((((.>.((.........))...(((((((.....(((....))).......))))))).]((((.(((..(((((....(((...((...(((((..((....))...)))))...))...)))..)))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).[..(((((.....>].)))))..((((((((.(((.((......((((.((((((..(((((.(((((((((.(((.((....(((((..({....[...(((((..((..............(...})...........))..].........))))))..)))))....)).)))....((.((((((.....)))))))).....)))))))))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..)))))).......((((.(.((((((...((.......))...))))))...)))).)........((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..a.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}..))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((....))))....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))...))))))))).) Mini-RNase III (Mini-III) bound to 50S ribosome with precursor 23S rRNA; pre-23S rRNA 6tnn V 116 3.07 RF00001 URS00001045F2_224308 32991829 0003735 0005840 224308 uuugguggcgauagcgaagaggucacacccguucccauaccgaacacggaaguuaagcucuucagcgccgaugguagucggggguuucccccugugagaguaggacgccgccaagc .<<<<<<<<....<<<<<<<<.....<<.<<...............>>...>>....>>>>>>.>>.<<.......<<.<<<<<...>>>>>.>>.......>>..>>>>>>>>.. ..(((((((....((((((((.....(..(((...(.....)...)).)...)....)))))).)).((.......((.(((((...))))).)).......))..)))))).).. Mini-RNase III (Mini-III) bound to 50S ribosome with precursor 23S rRNA; 5S rRNA 6tnu 2 1771 3.1 RF01960,RF01959,RF00177 URS0001A16A88_4932 32299921 0003735 0005840 4932 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugagcuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauu ...<<<<<...((((>>>>><<<<.<<<<<<...<.<...<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<..<<..<<....<<<..................<<....<<.<<<.....>>>.>>.....>>.........<<<<<..<<....>>..>>>>><.<.<<<<<<......[[.((((.<<<....>>>....<<......>>>>>>>>.>...>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>..>>>..>....>.>.....<<<<<<<.<<<<<....>>>>>.>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>>.........<<<{{.....<.<<...<<<.<<....<<<<<<.<<<<..............>>>>.>>>>>>.....<<<<<....................>>>>>....<<<<<.<<.......<<...<.......>..<<<<...>>>>....>>......>>.>>..>>>.........<<...<<<<<<<<.....)))).]].>>>>>>>>..>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>.>.>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..))))..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<.......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>>....>.>>>>>....>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>......<....<<<<<<..........>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<.<<<<.<<<<....>>>>.>>>>.>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>........ ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[..[[[.(.(....).).....(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.(((......)))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(((((((.(.(((....))).).)))).)))....(.((..(...........)..))......)..((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((................))).)))))).....(((((....................)))))....(((((.((.......((..((.......)).(((.....)))....))......)).))..)))........((....(.((.(((.....]].].]].))).)).)...)..)..))...(((.(((.((...((((..((..((((((.(...((........))......).))))))..)).......((....))...))))..)).)))..))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].].((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.((....(.((((((.(..(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..))))).)..))).))).....)..)))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....((((((((.......))))))))......))...)))))))))).)...(.(..((.(..((((.((..(.(((((((..(((..(.((..(...((((((..((((.((((....)))).))))..))))))...)..)).)..)))..))))))))..)).))))...).))...)..)..(((((((((....)))))))))>....... Yeast 80S ribosome in complex with eIF5A and decoding A-site and P-site tRNAs.; 18S rRNA 6tnu n 75 3.1 RF00005 URS00002CB170_4932 32299921 0030533 0006412 4932 agcgccgunncgcaguggaagcgcncagggcucaunacccugaununcucggaucgnaaccgagcggcgcuacca <<<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((....[..)))).(((((.......))))).....(((((..]....)))))))))))).... Yeast 80S ribosome in complex with eIF5A and decoding A-site and P-site tRNAs.; P-site tRNA 6tnu m 76 3.1 RF00005 URS000042DDAB_4932 32299921 0030533 0006412 4932 gggucguuagcucaguugguagagcaguugacuuuuaaucaauuggucgcagguucgaauccugcacgacccacca <<<<<<<..<<<<........>>>><<<<<<.......>>>>>>.....<<<<.......>>>>.>>>>>>>.... (((((((..((((........))))(.((((.......)))).).....((.(........))).))))))).... Yeast 80S ribosome in complex with eIF5A and decoding A-site and P-site tRNAs.; A-site tRNA 6tnu BQ 3184 3.1 RF02540,RF02543 URS0001A16A76_4932 32299921 0003735 0005840 4932 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaugguguuuuguauuucacuggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauagagggcuaccuuuauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<<.<<<<<<<<<<<<<<<<<<<<.....<<<<......>>>>.(.......<<<......)>>>....>>>>>>>>>..>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<.........................<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<....<<.<<<<<<<.....<<<....<<<..<.<<<<...<<<<<<.....>>>>>>.>>>>.>..>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>..>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><<<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>.>>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<<....>>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<...............>>>>><<.<<<<<<<<<<<....>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.....<<....<<<<<....>>>>.>...>>..>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<<<<<<<<......>>>>>>.>>>>>>>>>>...<<<<<.....<<<<..<<<<........>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<.<..<<<<........>>>>..>>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((...(((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))).)...)))..))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.(((((.......(..............)..(((((((((((((((((((((((.......(((((((......(((((((..))))))).......))))))).....))))).))))))))))........(((....)))....)))))))).....))))).))))).<((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))....))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((((((((((....((.(((((((.....(((....(((..(.((((...((((((.....)))))).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((.(((...((.........))...))).....(...(........).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))((((((((((.((......((((.((((....))))))))...)))))))))).)).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........((((.((.....).).))))....))....))...(((((........)))))]]((((..(((.(((...((((....)))...(.[[((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....)))...))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.((((((((((.(...)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.((((((((..((.((((((((((((((..)..)))))).))))))).))....((((.....((((..((((........))))..........]]...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((.(((((....{..)))).)))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....))))))))......(((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).)))))).)(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(((.((..)..).)))..)))))...)))....)))).)))))).))))).. Yeast 80S ribosome in complex with eIF5A and decoding A-site and P-site tRNAs.; 25S rRNA 6tnu BR 121 3.1 RF00001 URS000055688D_4932 32299921 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<....<<<.<<..............>>....>>...>>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Yeast 80S ribosome in complex with eIF5A and decoding A-site and P-site tRNAs.; 5S rRNA 6tnu BS 158 3.1 RF00002 URS00001BF64E_4932 32299921 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Yeast 80S ribosome in complex with eIF5A and decoding A-site and P-site tRNAs.; 5.8S rRNA 6tpq V 123 3.07 RF00001 URS0001CADAF5_224308 32991829 0003735 0005840 224308 uuuguuugguggcgauagcgaagaggucacacccguucccauaccgaacacggaaguuaagcucuucagcgccgaugguagucggggguuucccccugugagaguaggacgccgccaagcaag <<<<<<<<<<<<<....<<<<<<<<.....<<<<<<.............>>>>..>>....>>>>>>.>>.<<.......<<.<<<<<...>>>>>.>>.......>>..>>>>>>>>>>>>> .((((((((((((....((((((((.....((((((...(.....)...))))..))....)))))).)).((.......((.(((((...))))).)).......))..)))))))))))). RNase M5 bound to 50S ribosome with precursor 5S rRNA; pre-5S rRNA 6tpq U 2924 3.07 RF02540,RF02541,RF00002 URS0000B48F65_224308 32991829 0003735 0005840 224308 uuaaguuagaaagggcgcacgguggaugccuuggcacuaggagccgaugaaggacgggacgaacaccgauaugcuucggggagcuguaagcaagcuuugauccggagauuuccgaauggggaaacccaccacucguaauggagugguauccauaucugaauucauaggauaugagaaggcagacccggggaacugaaacaucuaaguacccggaggaagagaaagcaaaugcgauucccugaguagcggcgagcgaaacgggaucagcccaaaccaagaggcuugccucuugggguuguaggacacucuguacggaguuacaaaggaacgagguagaugaagaggucuggaaaggcccgccauaggagguaacagcccuguagucaaaacuucguucucuccugaguggauccugaguacggcggaacacgugaaauuccgucggaauccgggaggaccaucucccaaggcuaaauacucccuagugaccgauagugaaccaguaccgugagggaaaggugaaaagcaccccggaaggggagugaaagagauccugaaaccgugugccuacaaguagucagagcccguuaacgggugauggcgugccuuuuguagaaugaaccggcgaguuacgaucccgugcaagguuaagcagaagaugcggagccgcagcgaaagcgagucugaauagggcgcaugaguacguggucguagacccgaaaccaggugaucuacccauguccagggugaaguucagguaacacugaauggaggcccgaacccacgcacguugaaaagugcggggaugagguguggguaggggugaaaugccaaucgaaccuggagauagcugguucucuccgaaauagcuuuagggcuagccucaagguaagagucuuggagguagagcacugauuggacuaggggccccuaccggguuaccgaauucagucaaacuccgaaugccaaugacuuauccuugggagucagacugcgagugauaagauccguagucgaaagggaaacagcccagaccgccagcuaaggucccaaaguauacguuaaguggaaaaggauguggaguugcuuagacaaccaggauguuggcuuagaagcagccaccauuuaaagagugcguaauagcucacuggucgagugacucugcgccgaaaauguaccggggcuaaacguaucaccgaagcugcggacuguucuucgaacagugguaggagagcguucuaagggcugugaagccagaccggaaggacugguggagcgcuuagaagugagaaugccgguaugaguagcgaaagaggggugagaauccccuccaccgaaugccuaagguuuccugaggaaggcucguccgcucaggguuagucgggaccuaagccgaggccgaaaggcguaggcgauggacaacagguugauauuccuguaccaccuccucaccauuugagcaauggggggacgcaggaggauaggguaagcgcgguauuggauauccgcguccaagcaguuaggcugggaaauaggcaaauccguuucccauaaggcugagcugugauggcgagcgaaauauaguagcgaaguuccugauuccacacugccaagaaaagccucuagcgaggugagaggugcccguaccgcaaaccgacacagguaggcgaggagagaauccuaaggugaucgagagaacucucguuaaggaacucggcaaaaugaccccguaacuucgggagaaggggugcucuguuagggugcaagcccgagagagccgcagugaauaggcccaggcgacuguuuagcaaaaacacaggucucugcgaagccguaaggcgaaguauaggggcugacgccugcccggugcuggaagguuaagaggagcgcuuagcguaagcgaaggugcgaauugaagccccaguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgacccgcacgaaaggcgcaacgaucugggcacugucucaacgagagacucggugaaauuauaguaccugugaagaugcagguuacccgcgacaggacggaaagaccccguggagcuuuacugcagccugauauugaauguugguacagcuuguacaggauagguaggagccuuggaaaccggagcgccagcuuugguggaggcaucggugggauacuacccuggcuguauugaccuucuaacccgccgcccuuaucgggcggggagacagugucaggugggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguucccucagaaugguuggaaaucauucgcagaguguaaaggcacaagggagcuugacugcgagaccuacaagucgagcagggacgaaagucgggcuuagugauccggugguuccgcauggaagggccaucgcucaacggauaaaagcuaccccggggauaacaggcuuaucucccccaagaguccacaucgacggggagguuuggcaccucgaugucggcucaucgcauccuggggcuguagucggucccaaggguugggcuguucgcccauuaaagcgguacgcgagcuggguucagaacgucgugagacaguucggucccuauccgucgcgggcgcaggaaauuugagaggagcuguccuuaguacgagaggaccgggauggacgcaccgcugguguaccaguuguucugccaagggcaucgcuggguagcuaugugcggacgggauaagugcugaaagcaucuaagcaugaagccccccucaagaugagauuucccauuccgcaaggaaguaagaucccugaaagaugaucagguugauaggucugagguggaaguguggcgacacauggagcugacagauacuaaucgaucgaggacuuaacc <<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<.....((.>>>.....<<<<<<<..<<<)).....>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<<<<<<<<.........>>>>>>>.>>.>>....<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<......<<.....>>.....>>>>...(((....<<<<<<<<....>>>>>>>>......<<<<<<<<<.....<<<<.......<<<<<<<<<<.<<<.....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>.>>>>>..>>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<......>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<.<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>......>>>>>.>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<...<<<<<<<<<.....<<<...<<<<<<<<......<<<<.....>>>>.......>>>>>>>>..>>.>.....>>>>.>>>>>..>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<.....................>>.........<<......>>...>>>>>....>>>>>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<...>>>>>>>....>>>>>><.<<<<<<<.<<......<<<<<.<<....>>.>>>>>...>>.>>>>>>>..>.....>>>>>><......<<....<<<<<<.......>>>>>><<<<....<<<<<.<<<..<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<.<<<<<<......<<...<<<<....<<<<..<<<..<<<.<.<<<.......{......>>>.<<..<......<<.<.<<<<<<<.<<.....>>>>>>>>>....>.>>......>...>><..<<...........>>...>>.>>>...>>>...>>>>.........>>>>..>>..>>>>>>>>>>>>>>>.>>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<....<<<<....>>>>...>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>..<<<<.<<<..<<<<<<<..<<<<..<<...<<<<<<.<<....>>..>>>>>>...>>..>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>...>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<<.<<<.<<<<..<<<<.............<<<<...<<...............................>>.............>>>>....>>>>..>>>>.>>>....<<.<<<<<<.....>>>>>>>>.....>>>>>>>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.}..>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>.. ((((((......((((((((((.....(((..(((((((((((((......((((((.....[[[)))...].((((((...(((]].....)))......))))))...)))....(((....)))(((((((......))))))).(((((((((.........))))))).)).))....((((((.....(...[..)......))))).).........((....))...((((......((.]...)).....))))...((((...((((((((....))))))))....{.(((((((((.....((((........(((((((((.(((...(.((((......)))))[[(...).(((.....]])))...)))...))))))))).)))).)))))..)))))....((((((((..[......))))))))....}.(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((..((((..[...))))..)))).<.(.(........).).((((((..(.(((((((.(((((..(((...(((.....)))...)))...((....))..((((.....))))......))))).)))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)<)))...(((.(((((.......A))))))))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))(((((((((...(((((((((.....(((...((((((((......((((.....)))).......))))))))..)).).....)))).)))))..))))))).))..(((((((.((......)).)))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.((...((...........))...)).....(...((......)).).)))))...)))))))))).))...........]]].)...))))))))))...)))))))(((((((...)))))))....))))))(((((((...((......(((((.((....))])))))...))...))))).)).....))))))(......((....((((((.......))))))((((....(((...((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((.(((((.......((...((((....((((..(((..(((.(.(((.......{......))).((....(....((.(..((((((.((.....))))))).)....).)).....)....))(..((..(......).))...)).)))...)))...))))(..).....))))..))...)))))))))))))).))).....((......))..))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.[..).....)))))(((((....((((....))))...)))))(...).......(((((((((.>.((.........))...(((((((.....(((....))).......))))))).]((((.(((..(((((((..(((...((...(((((..((....))...)))))...))...))))))))..)))))(((((.........)))))........((.(......).(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).[..(((((.....>].)))))..((((((((.(((.((......((((.((((((..(((((.(((((((((.(((.((....(((((..(.....[...((.(...(.(.............(....)...........))..]..........).))).).))))....)).)))....((.((((((.....)))))))).....)))))))))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..a.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}..))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((....))))....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))...))))))).. RNase M5 bound to 50S ribosome with precursor 5S rRNA; pre-23S rRNA 6tw1 V 33 2.7 URS0001A16A94_11520 32304664 11520 aguaguaacaagagcaauguguccgucucugcu .<<....>>........................ .((....))........................ Bat Influenza A polymerase termination complex with pyrophosphate using 44-mer vRNA template with mutated oligo(U) sequence; vRNA 6tw1 M 10 2.7 32304664 11520 acggacacau .......... .......... Bat Influenza A polymerase termination complex with pyrophosphate using 44-mer vRNA template with mutated oligo(U) sequence; mRNA 6ty9 N 19 2.9 URS000197CF75_110829 31695188 110829 nguaauuuuuuuuuuuuuu ................... ................... In situ structure of BmCPV RNA dependent RNA polymerase at initiation state; Non-template RNA (5'-D(*(GTA))-R(P*GP*UP*AP*AP*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*U)-3') 6ty9 T 19 2.9 URS000197CF7B_110829 31695188 110829 aaaaaaaaaaaaaauuacu ................... ................... In situ structure of BmCPV RNA dependent RNA polymerase at initiation state; Template RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*UP*UP*AP*CP*U)-3') 6tz1 T 11 3.4 URS000080E35F_110829 31695188 110829 aaaaaaaaaaa ........... ........... In situ structure of BmCPV RNA-dependent RNA polymerase at early-elongation state; Template RNA (5'-R(P*AP*GP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 6tz2 M 18 3.5 URS000197CF55_110829 31695188 110829 uuuuuuuuuuuuuuuuuu .................. .................. In situ structure of BmCPV RNA-dependent RNA polymerase at elongation state; Transcript RNA (5'-R(P*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*U)-3') 6tz2 N 36 3.5 URS000080E030_110829 31695188 110829 uuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuu .................................... .................................... In situ structure of BmCPV RNA-dependent RNA polymerase at elongation state; Non-template RNA (36-MER) 6tz2 T 36 3.5 URS000197CF5C_110829 31695188 110829 aaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa .................................... .................................... In situ structure of BmCPV RNA-dependent RNA polymerase at elongation state; Template RNA (36-MER) 6u48 CA 2898 2.87 RF02540,RF02541 URS00021ED982_562 31594941 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccuu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<.<....<<<<<...<<<<<.<<<....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>...>>>>>..>>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<.>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<...<........<<<<<.<<<..<<<<.......>>>>..>>>........<<<......>>>..>>>>>....>...>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<..<<....>>..>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<<.<<....>>..>>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>.............>>>>...>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>.. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.(.((......(((.....(((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))).....)))...)).)...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((....((.(...).).)....)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((.((..(((.....{.(((((.(((..(((.........)))..))).....(...((......)).).)))))...)))..)).)).))...........]]].)...))))))))))...)))))))((((..............))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...(((.((((((((.((.....))))))))))...)))..[))))...))(...((((....))))....))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((...(....(.(..........(.((..(((.......((.((((....)))).))....)))............)).).).)....)...)))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).).....((.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..))....(.(((((....))).)).)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))).. E. coli 50S with phazolicin (PHZ) bound in exit tunnel; 23S rRNA 6u48 CB 118 2.87 RF00001 URS0000366A67_562 31594941 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (((((((((.....((((((((....(((.((....(.....)....))...)))...)))))).)).((.......((((((((...)))))))).......))...))))))))). E. coli 50S with phazolicin (PHZ) bound in exit tunnel; 5S rRNA 6u6j A 15 1.6 31651170 32630 nnnnacuuaagucgn ............... ............... RNA-monomer complex containing pyrophosphate linkage; RNA (5'-R(*(LCC)P*(LCC)P*(LCC)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*G*(DPG))-3') 6u6j B 15 1.6 31651170 32630 nnnnacuuaagucgn ............... ............... RNA-monomer complex containing pyrophosphate linkage; RNA (5'-R(*(LCC)P*(LCC)P*(LCC)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*G*(DPG))-3') 6u7y A 22 2.95 URS00021ED93B_32630 33347562 32630 cugcuggcuaagggccgaaagg ..............<<....>> ..............((....)) RNA hairpin structure containing one TNA nucleotide as template; RNA (5'-R(*CP*UP*GP*CP*UP*GP*GP*CP*UP*AP*AP*GP*GP*(TG)P*CP*CP*GP*AP*AP*AP*GP*G)-3') 6u7y B 12 2.95 URS0000CBFF20_32630 33347562 32630 cuaugccugcug ............ ............ RNA hairpin structure containing one TNA nucleotide as template; RNA (5'-R(*CP*UP*AP*UP*GP*CP*CP*UP*GP*CP*UP*G)-3') 6u7z A 22 2.71 URS00021ED93B_32630 33347562 32630 cugcuggcuaagggccgaaagg ..............<<....>> ..............((....)) RNA hairpin structure containing one TNA nucleotide as primer; RNA (5'-R(*CP*UP*GP*CP*UP*GP*GP*CP*UP*AP*AP*GP*GP*GP*CP*CP*GP*AP*AP*AP*GP*(TG))-3') 6u7z B 12 2.71 URS0000CBFF20_32630 33347562 32630 cuaugccugcug ............ ............ RNA hairpin structure containing one TNA nucleotide as primer; RNA (5'-R(*CP*UP*AP*UP*GP*CP*CP*UP*GP*CP*UP*G)-3') 6u8f A 22 2.81 URS00021ED993_32630 33347562 32630 cugcuggcuaaggcaugaaagu ..............<<....>> ..............((....)) RNA hairpin, bound with TNA monomer; RNA (5'-R(*CP*UP*GP*CP*UP*GP*GP*CP*UP*AP*AP*GP*GP*CP*AP*UP*GP*AP*AP*AP*GP*U)-3') 6u8f B 12 2.81 URS0000CBFF20_32630 33347562 32630 cuaugccugcug ............ ............ RNA hairpin, bound with TNA monomer; RNA (5'-R(P*CP*UP*AP*UP*GP*CP*CP*UP*GP*CP*UP*G)-3') 6u8u A 14 2.4 33347562 32630 nnnnacuuaagucg .............. .............. RNA duplex bound with TNA 3'-3' imidazolium dimer; RNA (5'-R(*(LCC)P*(LCC)P*(LCC)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*G)-3') 6u8u B 14 2.4 33347562 32630 nnnnacuuaagucg .............. .............. RNA duplex bound with TNA 3'-3' imidazolium dimer; RNA (5'-R(*(LCC)P*(LCC)P*(LCC)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*G)-3') 6ucq 1A 2871 3.5 RF02540,RF02541,RF00002 URS00001698E8_300852 31873307 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>....<<<<<.....<......>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<.....<<<........>>>......>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..<<<.......>>>...>>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<.<<....>>.>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<.<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>..>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((...((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((.(...(..(......)..)...)..)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{..((((.(((..((.........))...))).....(...((......)).).))))....)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((.............)))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(......[..(((((..(((......(((((.((....)).)))))...)))..........].)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..((.((((((......))))))...)).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..(((...)))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the Thermus thermophilus 70S ribosome recycling complex; 23S Ribosomal RNA 6ucq 1B 120 3.5 RF00001 URS000080DEE8_300852 31873307 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the Thermus thermophilus 70S ribosome recycling complex; 5S Ribosomal RNA 6ucq 1a 1499 3.5 RF00177,RF01959,RF01960 URS000080DFED_300852 31873307 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguagucccgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<...<<<<<<......>>>>>.>...>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<.<<...<<...<<<<.<.....>.>>>>...>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>...<<<......>>>...>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((((((....))))))).)))))......(((......((((((((..((...(((((((.(((((....(((((......))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....(((.((...((...((((.........))))...)))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((((((....)))))))....(((....)))....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((...((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))....))...)..)..(((((((((....)))))))))}.... Crystal structure of the Thermus thermophilus 70S ribosome recycling complex; 16S Ribosomal RNA 6ucq 1x 74 3.5 RF00005 URS00005AA258_562 31873307 0030533 0006412 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[..)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of the Thermus thermophilus 70S ribosome recycling complex; P-site and E-site tRNAs 6ucq 1y 74 3.5 RF00005 URS00005AA258_562 31873307 0030533 0006412 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((......)))).((((.........)))).....(((((.......)))))))))))).... Crystal structure of the Thermus thermophilus 70S ribosome recycling complex; P-site and E-site tRNAs 6ucq 1z 10 3.5 31873307 32630 aaaauucuaa .......... .......... Crystal structure of the Thermus thermophilus 70S ribosome recycling complex; mRNA 6ucq 2A 2800 3.5 RF02540,RF02541,RF00002 URS00001698E8_300852 31873307 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<.......>>>....<<..>>...>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<....<<...<<<<<<<<...<<<............>.>>...>>>>>>>>..>>.....>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<..>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<..>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<....<<..>>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<.........>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<.<......<<<<<<<<....>>>>>>>>...>.>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>......>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....(())....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((.(((...(((....((.((((.....((..........))......)))).))...)).)...))).)))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((.((((.().)))).))).))..........]]].)....))))))))))...)))))))(((((((..)))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((.(...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((...((.....))..))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...)....))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))((((...........))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(......[..(((((...((.......((((.((....)).))))....))...........].)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...((.((((.(.(((((.........)))))...).((][.[[[))....)))).))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....))))))).(((.))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the Thermus thermophilus 70S ribosome recycling complex; 23S Ribosomal RNA 6ucq 2B 120 3.5 RF00001 URS000080DEE8_300852 31873307 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<.....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>..>>>>>>>>>. .((((((((((....((((((.(....(((((((...(.....)...))))..)))...).)))).)).((.......((((((((....)))))))).......))..)))))))))). Crystal structure of the Thermus thermophilus 70S ribosome recycling complex; 5S Ribosomal RNA 6ucq 2a 1503 3.5 RF00177,RF01959,RF01960 URS000080DFED_300852 31873307 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggau .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<...<<<<<<......>>>>>.>...>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<.<<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<.<..<<<<<<<.<..<<<......>>>.....>.>>>>>>>...>.......<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<......>>....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>.>>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>.... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...((((.((.(((((....((((.(....).)))).....)))))....((((.(((((....))))).))))...((((...)))).)).))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..(((((((......)))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{....(((((..((((.(((((...))))).))))...((.].])).....))))).)))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((((((....)))))))....(((....)))....)))))))).((.(((...((.(((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).))....)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(.(..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..).).))))..).))...)..)..(((((((((....)))))))))}... Crystal structure of the Thermus thermophilus 70S ribosome recycling complex; 16S Ribosomal RNA 6ucq 2x 74 3.5 RF00005 URS00005AA258_562 31873307 0030533 0006412 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[..)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of the Thermus thermophilus 70S ribosome recycling complex; P-site and E-site tRNAs 6ucq 2y 74 3.5 RF00005 URS00005AA258_562 31873307 0030533 0006412 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca .<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((...[..)))).((((.........)))).....((((...].....))))))))))..... Crystal structure of the Thermus thermophilus 70S ribosome recycling complex; P-site and E-site tRNAs 6ucq 2z 10 3.5 31873307 32630 aaaauucuaa .......... .......... Crystal structure of the Thermus thermophilus 70S ribosome recycling complex; mRNA 6uey A 50 2.8 RF02679 URS0001A16A60_562 31804735 0003824 562 acucguuugagcgaguauaaacaguugguuaggcucaaagcggagagcag .((((<<<<<<))))..................>>>>>>........... .[[[[((((((]]]].................[)))))).]......... Pistol ribozyme transition-state analog vanadate; RNA (50-MER) 6uey B 15 2.8 URS0001A16A75_562 31804735 562 ucugcucucnuccaa ............... ............... Pistol ribozyme transition-state analog vanadate; RNA (5'-R(*UP*CP*UP*GP*CP*UP*CP*UP*CP*(GVA)*UP*CP*CP*AP*A)-3') 6uey C 50 2.8 RF02679 URS0001A16A60_562 31804735 0003824 562 acucguuugagcgaguauaaacaguugguuaggcucaaagcggagagcag (((((<<<<<<))))).................>>>>>>........... [[[[[((((((]]]]]................[)))))).]......... Pistol ribozyme transition-state analog vanadate; RNA (50-MER) 6uey D 15 2.8 URS0001A16A75_562 31804735 562 ucugcucucnuccaa ............... ............... Pistol ribozyme transition-state analog vanadate; RNA (5'-R(*UP*CP*UP*GP*CP*UP*CP*UP*CP*(GVA)*UP*CP*CP*AP*A)-3') 6uf1 A 50 3.1 RF02679 URS0001A16A60_562 31804735 0003824 562 acucguuugagcgaguauaaacaguugguuaggcucaaagcggagagcag .((((<<<<<<))))..................>>>>>>........... .[[[[((((((]]]].................[)))))).]......... Pistol ribozyme transition-state analog vanadate; RNA (50-MER) 6uf1 B 15 3.1 URS0001A16A75_562 31804735 562 ucugcucucnuccaa ............... ............... Pistol ribozyme transition-state analog vanadate; RNA (5'-R(*UP*CP*UP*GP*CP*UP*CP*UP*CP*(GVA)*UP*CP*CP*AP*A)-3') 6uf1 C 50 3.1 RF02679 URS0001A16A60_562 31804735 0003824 562 acucguuugagcgaguauaaacaguugguuaggcucaaagcggagagcag (((((<<<<<<))))).................>>>>>>........... [[[[[((((((]]]]]................[)))))).]......... Pistol ribozyme transition-state analog vanadate; RNA (50-MER) 6uf1 D 15 3.1 URS0001A16A75_562 31804735 562 ucugcucucnuccaa ............... ............... Pistol ribozyme transition-state analog vanadate; RNA (5'-R(*UP*CP*UP*GP*CP*UP*CP*UP*CP*(GVA)*UP*CP*CP*AP*A)-3') 6ufg B 77 2.929 RF00005 URS000197CF6B_1773 31740853 0030533 0006412 1773 gggccuauagcucaggcgguuagagcgcuucgcugauaacgaagaggucggagguucaaguccuccuaggcccgcca <<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[...)))).(((((.......))))).....(((((..]....)))))))))))).... Co-crystal structure of M. tuberculosis ileS T-box in complex with tRNA-3'-OH; RNA (77-MER) 6ufg A 162 2.929 URS000197CF59_1773 31740853 1773 ngcaucgauccggcgaucaccggggagccuucggaagaacggccaggcccaguagaaccgaacggguuggcccgucacagccucaagucgagcggccgcgcgaaagcguggcaagcgggguggcaccgcggcguucgcgcgaaagcguggcgucguccccgn <<<.....<<<<<......>>>>>..>>><<<<<......<<<<.>>>>........>>>>><<<...(((>>>.....)))............<<<<<<<....>>>>>>>..<<<<<<.......<<<<<<<.<<<<<....>>>>>>>>>>>>>>>>>> (((......((((......))))...)))(((((......((((.))))........)))))(((...[[[))).....]]].........[..(((((((....)))))))..((((((......](((((((.(((((....)))))))))))))))))) Co-crystal structure of M. tuberculosis ileS T-box in complex with tRNA-3'-OH; RNA (166-MER) 6ufh B 77 3.104 RF00005 URS000197CF6B_1773 31740853 0030533 0006412 1773 gggccuauagcucaggcgguuagagcgcuucgcugauaacgaagaggucggagguucaaguccuccuaggcccgccn <<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[...)))).(((((.......))))).....(((((..]....)))))))))))).... Co-crystal structure of M. tuberculosis ileS T-box in complex with tRNA-3'-2'3'cyclic phosphate; RNA (77-MER) 6ufh A 167 3.104 URS000197CF5F_1773 31740853 1773 ngcaucgauccggcgaucaccggggagccuucggaagaacggccggaaacggcccaguagaaccgaacggguuggcccgucacagccucaagucgagcggccgcgcgaaagcguggcaagcgggguggcaccgcggcguucgcgcgaaagcguggcgucguccccgn .<<.....<<<<<......>>>>>..>>.<<<<<......<<<<<....>>>>>........>>>>><<<...(((>>>.....)))............<<<<<<<....>>>>>>>..<<<<<<.......<<<<<<<.<<<<<....>>>>>>>>>>>>>>>>>> .((......((((......))))...)).(((((......(((((....)))))........))))).[[...(((]]......)))............(((((((....)))))))..((((((.......(((((((.(((((....)))))))))))))))))) Co-crystal structure of M. tuberculosis ileS T-box in complex with tRNA-3'-2'3'cyclic phosphate; RNA (167-MER) 6ufj A 50 2.645 RF02679 URS0001A16A65_32630 31804735 0003824 32630 acucguuugagcgaguauaaacagcugguuaagcucaaagcggagagcag .((((<<<<<<))))..................>>>>>>........... .[[[[((((((]]]].................[)))))).]......... Pistol ribozyme product crystal structure; RNA (50-MER) 6ufj B 10 2.645 URS00021ED93E_32630 31804735 32630 ucugcucucn .......... .......... Pistol ribozyme product crystal structure; RNA (5'-R(*UP*CP*UP*GP*CP*UP*CP*UP*CP*(23G))-3') 6ufj C 50 2.645 RF02679 URS0001A16A65_32630 31804735 0003824 32630 acucguuugagcgaguauaaacagcugguuaagcucaaagcggagagcag (((((<<<<<<))))).................>>>>>>........... [[[[[((((((]]]]]................[)))))).]......... Pistol ribozyme product crystal structure; RNA (50-MER) 6ufj D 10 2.645 URS00021ED93E_32630 31804735 32630 ucugcucucn .......... .......... Pistol ribozyme product crystal structure; RNA (5'-R(*UP*CP*UP*GP*CP*UP*CP*UP*CP*(23G))-3') 6ufk A 50 3.2 RF02679 URS0001A16A65_32630 31804735 0003824 32630 acucguuugagcgaguauaaacagcugguuaagcucaaagcggagagcag .((((<<<<<<))))..................>>>>>>........... .[[[[((((((]]]].................[)))))).]......... Pistol ribozyme product crystal soaked in Mn2+; RNA (50-MER) 6ufk B 10 3.2 URS00021ED93E_32630 31804735 32630 ucugcucucn .......... .......... Pistol ribozyme product crystal soaked in Mn2+; RNA (5'-R(*UP*CP*UP*GP*CP*UP*CP*UP*CP*(23G))-3') 6ufk C 50 3.2 RF02679 URS0001A16A65_32630 31804735 0003824 32630 acucguuugagcgaguauaaacagcugguuaagcucaaagcggagagcag (((((<<<<<<))))).................>>>>>>........... [[[[[((((((]]]]]................[)))))).]......... Pistol ribozyme product crystal soaked in Mn2+; RNA (50-MER) 6ufk D 10 3.2 URS00021ED93E_32630 31804735 32630 ucugcucucn .......... .......... Pistol ribozyme product crystal soaked in Mn2+; RNA (5'-R(*UP*CP*UP*GP*CP*UP*CP*UP*CP*(23G))-3') 6ufm A 77 2.82 RF00005 URS0000122913_1772 31792448 0030533 0006412 1772 gggccuauagcucaggcgguuagagcgcuucgcugauaacgaagaggucggagguucgaguccuccuaggcccacca <<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[...)))).(((((.......))))).....(((((..]....)))))))))))).... Cocrystal Structure of the Nocardia farcinica ileS T-box riboswitch in complex with its cognate tRNA; RNA (77-MER) 6ufm B 98 2.82 URS000197CF74_37329 31792448 37329 ggcgacgauccggccaucaccggggagccuucggaagaacggcgccgccggaaacggcggcgcucaguagaaccgaacgggugagcccgucacagcuc <<<.....<<<<<......>>>>>..>>><<<<<......<<<<<<<<<<....>>>>>>>>>>........>>>>>(((..<<<<))).....>>>> (((......((((......))))...)))(((((......((((((((((....))))))))))........)))))[[[..((((]]].....)))) Cocrystal Structure of the Nocardia farcinica ileS T-box riboswitch in complex with its cognate tRNA; RNA (98-MER) 6uo1 1A 2871 2.95 RF02540,RF02541,RF00002 URS00001698E8_300852 31672910 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<....<<<<........>>>.>....>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...........(........>>.........<<......>>.).>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<.......<<<<.<<....>>.>>>>....>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<...>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((...((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((.(..(((.(......).))..))..)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((.(((.....{.(((((.(((..((.........))...))).....(...((......)).).)))))...))).)))))).))..........]]].)....))))))))))...)))))))(((((((.......)))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((.((((((((.(.........(((((..(((.......((((.((....)).))))....)))............)))))).)))))))).)))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..(((...)))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA (containing pseudouridine at the first position of the codon) and deacylated A-, P-, and E-site tRNAs at 2.95A resolution; 23S Ribosomal RNA 6uo1 1B 120 2.95 RF00001 URS000080DEE8_300852 31672910 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA (containing pseudouridine at the first position of the codon) and deacylated A-, P-, and E-site tRNAs at 2.95A resolution; 5S Ribosomal RNA 6uo1 1a 1500 2.95 RF00177,RF01959,RF01960 URS000080DFED_300852 31672910 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<.<<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<......>>....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((((((....))))))).)))))......(((......((((((((..((...(((((((.((((.....(((((......)))))......))))....((((..((((....))))..))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(.(((....)))..))))).)).))))))..((((......((((....)))).....))))....(((((...(....(.((.....)).).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((.((...)).)))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((((((....)))))))....(((....)))....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA (containing pseudouridine at the first position of the codon) and deacylated A-, P-, and E-site tRNAs at 2.95A resolution; 16S Ribosomal RNA 6uo1 1v 13 2.95 31672910 10665 aaaaauguuuuaa ............. ............. Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA (containing pseudouridine at the first position of the codon) and deacylated A-, P-, and E-site tRNAs at 2.95A resolution; mRNA 6uo1 1w 71 2.95 RF00005 URS00005AA258_562 31672910 0030533 0006412 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggca <<<<<<<..<<<<......>>>><<<<<<<.....>>>>>>.>...<<<<<.......>>>>>>>>>>>>. (((((((..((((...[..)))).((((.........)))).....((.((..]....)).))))))))). Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA (containing pseudouridine at the first position of the codon) and deacylated A-, P-, and E-site tRNAs at 2.95A resolution; A-site and E-site tRNAs 6uo1 1x 76 2.95 RF00005 URS000041AF00_562 31672910 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA (containing pseudouridine at the first position of the codon) and deacylated A-, P-, and E-site tRNAs at 2.95A resolution; P-site tRNA 6uo1 1y 74 2.95 RF00005 URS00005AA258_562 31672910 0030533 0006412 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((......)))).((((.........)))).....(((((.......)))))))))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA (containing pseudouridine at the first position of the codon) and deacylated A-, P-, and E-site tRNAs at 2.95A resolution; A-site and E-site tRNAs 6uo1 2A 2800 2.95 RF02540,RF02541,RF00002 URS00001698E8_300852 31672910 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<........>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<..>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<..>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<...<<......<<<<<<<<....>>>>>>>>...>>.............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<<..<<.......>>>..>>>>>>...>>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>......>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> ((.......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....(())....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((.....((..........))......)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((....)))))))).))..........]]].)....))))))))))...)))))))(((((((..)))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((.(((((((((.(......[..(((((...((......(((((.((....)).)))))...))...........].)))))).))))))))).))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....))))))).(((.))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...)))).....)) Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA (containing pseudouridine at the first position of the codon) and deacylated A-, P-, and E-site tRNAs at 2.95A resolution; 23S Ribosomal RNA 6uo1 2B 120 2.95 RF00001 URS000080DEE8_300852 31672910 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA (containing pseudouridine at the first position of the codon) and deacylated A-, P-, and E-site tRNAs at 2.95A resolution; 5S Ribosomal RNA 6uo1 2a 1503 2.95 RF00177,RF01959,RF01960 URS000080DFED_300852 31672910 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggau .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<.<<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>..>>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<......>>....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((.(....).)))).....)))))....((((..((((....))))..))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.(((....(((.(((((.(.((.(((((((......((((((.....))))))....)))))))...))).)))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))....)))....((((((...((...((((.........))))...))))))))......{...((((((..((.(((((((...))))))).))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((((((....)))))))......(....)......)))))))).((.((....((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...))..))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.(.((....)).)).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}... Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA (containing pseudouridine at the first position of the codon) and deacylated A-, P-, and E-site tRNAs at 2.95A resolution; 16S Ribosomal RNA 6uo1 2w 69 2.95 RF00005 URS00005AA258_562 31672910 0030533 0006412 562 cccgganagcucagggagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggca <<<<<<..<<<<.....>>>><<<<<<<.....>>>>>>.>...<<<<<.......>>>>>>>>>>>.. ((((((..((((...[.)))).((((.........)))).....((.((..]....)).)))))))).. Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA (containing pseudouridine at the first position of the codon) and deacylated A-, P-, and E-site tRNAs at 2.95A resolution; A-site and E-site tRNAs 6uo1 2x 76 2.95 RF00005 URS000041AF00_562 31672910 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA (containing pseudouridine at the first position of the codon) and deacylated A-, P-, and E-site tRNAs at 2.95A resolution; P-site tRNA 6uo1 2y 73 2.95 RF00005 URS00005AA258_562 31672910 0030533 0006412 562 gcccgganagcucagggagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<.....>>>>.<<<<<<.....>>>>>>......<<<<.......>>>>.>>>>>>>.... (((((((..((((...[.)))).((((.........))))......((((..]....)))).))))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA (containing pseudouridine at the first position of the codon) and deacylated A-, P-, and E-site tRNAs at 2.95A resolution; A-site and E-site tRNAs 6uz7 5 3269 3.6 RF02540,RF02543 URS0001A16A68_28985 31900355 0003735 0005840 28985 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........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<<.<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<<<<........<<<<<<<.<<<<<<<<<<<<<<<.....<<<<.<<<<......<<<<<<<....>>>>>>>.......>>>>.>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>>>>>>>..<<<<........>>>><<<<<<.....<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<....>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>...<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<....<<.<<<<<<<.....<<<....<<<....<<<<..<<<<<<<.....>>>>>>>>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>..>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<......>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<...<.<<<....>>>.......<<<<<<...<<<<.<<<<.<<.<<<<<<<<<<..{{{..>>>>>>....<<<<<....<<<<<.....<<<.....>>>.....>>>>>.....>>>>>.....<<<<<<<......>>>>>>>>>>>...>>.>>>>.>>>>.........>>>>>>.....>....>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<...............>>>>><<.<<<<<<<<<<<.....<...<<<..<<<<....<<<<..>>>>....>>>>..>>>...............>.........>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<....<<<<<....>>>>.>...>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<..<.....<<<<..........<<<<<..<<....>>............>>>>>.>>>>.....>...>>>>>...<<<<<.....<<<<................................<..<.<.....>>..>..>>>>..>>>>>.....>>>>>>>>..>>>>>....<<.....>>...<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<..<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<....<<<<<<<<<.}}}..>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<<<..<<<......>>>..>>>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((..((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))......)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((((((((........(((((((((((((((((((((((.......((.((((......((((.((....)).)))).......)))).)).....))))).))))))))))........(((....)))....)))))))).....))))))))))).[((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..((((....))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((........)))).)))..).))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((((((((((....((.(((((((.....(((....(((..(.((((..(..(((.......)))..))))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.......(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((..((((((....((.....))..)))))....[[(((.((...((....(((....)))........((((((......))))))....))....))...(((((........)))))]]((((..(((((.(....(((....)))...(.<.((((((...((((.((((.(((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((........)))))))))).).)).)))).))))(...)....))))))...).....).))..))).)))).))).))).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((((.(........(((..((((....((((()))))....))))..))).........................)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...(.......(((....))).......).)))))..))))).(((...........))).........((..........(.(((.......))).)..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((......(((........[..(((((..(......)..........].)))))..)))......).))))))....((((.....((((..(...(......)...)...........>.....(.(.....)).....))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))....))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..)))))..(((...((((.............))))...)))..))))....)))))))).......((((((.(.(.((....((.(........((((((.....)))))).....))).......((((((...(((((((..(((......)))..))))))).)))))).............)).).).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. K.lactis 80S ribosome with p/PE tRNA and eIF5B; 25S ribosomal RNA 6uz7 7 121 3.6 RF00001 URS000055688D_28985 31900355 0003735 0005840 28985 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). K.lactis 80S ribosome with p/PE tRNA and eIF5B; RNA (121-MER) 6uz7 8 157 3.6 RF01960,RF01959,RF00177,RF02543,RF02540,RF00002 URS0001A16A7C_28985 31900355 0003735 0005840 28985 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaauugcgauauguauugugaauugcagauuuucgugaaucaucaaaucuuugaacgcacauugcgcccucugguauuccagggggcaugccuguuugagcgucauu .........................................<<<<<<.<<.....>>>.....<..<<......>>..............>>...>...>>>....<<.....>><<<<<<<<<....>>>>>>>>>.................... .........................................((((((.[[.....))).....(..(((.....]]............).))...)...)))....((.....))(((((((((....))))))))).................... K.lactis 80S ribosome with p/PE tRNA and eIF5B; 5.8S ribosomal RNA 6uz7 2 1780 3.6 RF01960,RF01959,RF00177 URS0000A76325_28985 31900355 0003735 0005840 28985 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacauggauaucugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacuccuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaacuggagggcaagucuggugccagcagccgcgguaauuccagcuccaguagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggucugguuguccggucgguuuuucaaccggaucuuuccuucuggcuaaccuguacuccuugugggugcaggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcgaaagcucgaauauauuagcauggaauaauggaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuucuuaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaggguugcuggcacuugccgguugacucuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgaguacaaccuuggccgagaggucuggguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggauuugcuuagagaagggggcaacuccaucucagagcgaagaaucuggucaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.{.[[[[>>>>><<<<.<<<<<<...<.<...<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<..<<..<<....<<<................<<.....<<.<<.......>>.>>......>>........<<<<<..<......>..>>>>><...<<<<<<......(((((((.<<<....>>>..............>>>>>>.....>...<<<<..<.........>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>...<<....>>.....>>>>>>.........<<<....<<<.....>>>..>>>..>....>.>.....<<<<<<<<<<..........>>>>>>>.>>.>.....<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>>.........<<<[[.....<.<<...<<<.<<....<<<<<<<<<<<.....<..>.....>>>>>>>>>>>.....<<<<<....<<<...<<.......>>...>>>....>>>>>....<<<<<.<<.......<<...<.......>..<<<....>>>....>>......>>.>>..>>>..........<...<<<<<<<<.....))))))).>>>>>>>>..>......>>....<<<<<<.<<...<<<<...<..<<<<<<.<...<<........>>......>.>>>>>.>.>........<<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..]]>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..]]]].}<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<.<......<<........>>..........<<<<<......<<<<<.....<..<<.<............>.>>.>....>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<......>>...<<<......>>>...>>.>>>....<<<<..<<..<<<<..<<<<<<<<<<<<....>>>>>>.>>>>>>..>>>>.>>....<<<<<<.....>>>>>>........>>>>....>>>.>>>.....>>>>>>>.......>>>>>...>..>>>>.>>>.....<<<<<<<.......<.....<<..<<<<....>>>>..>>....>........>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<..<...<<<<<<..<...................>...>>>>>>...>..>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((................((.....((.(((.....))).))......))........(((((..((....))..)))))(.((.(((((.......[[[[[[.(((....))).....(......).)))))).)...).(.((((..((.(....))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....((.((((((...(....)...))))))..))......(((.(...........)).)).........(((.([[....(.((((.....((..]])).......)))))).)))..))))))))))..{......((({{...(.(.((...(((.((....(((((((((((.....(()).....))))))))))).....(((((.........(.(.......).).........)))))....(((((.((.......((..((.......)).(((....)))....))......)).))..))).........(((..(.((.(((.....]]]]]]..))).)).)).)).....))....((..((.((...((((..(((.((((((.....(..........)........)))))).))).......((....))...))))..)).))...))...)))...)).)....(((((.........((.............))......)))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((..(...((..(........((.(............)).)......)..))......(((...(.((((((....(((.(..((....))...(.((......)))....).)))....(((((.((..((((..(((((..(((((....)))))...)))))..)))).))..(.(((((.......)))))....)..)))))....))).))).....).))).......).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..((((..(...((((((..........................))))))...)..))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>........ K.lactis 80S ribosome with p/PE tRNA and eIF5B; 18S ribosomal RNA 6uz7 3 76 3.6 RF00005 URS0001A16A64_4932 31900355 0030533 0006412 4932 gcccggauagcucagaagguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<.<.<...<<<<........>>>>.<<<<<<.....>>>>>>.........<........>.....>.>>>.... ..((.....((.(.....[..).)).(((((.......))))).....(.(.(..].....).))....))..... K.lactis 80S ribosome with p/PE tRNA and eIF5B; RNA (76-MER) 6v39 AN1 2892 3.04 RF02540,RF02541 URS00000BF98D_480119 31964740 0003735 0005840 480119 agucaaguaauuaagugcaugugguggaugccuuggcagucagaggcgaugaaagacgugauagccugcgaaaagcuccggggaggcggcaaauauccuuugauccggagaugucugaaugggggaacccaccuacuuuaagguagguauugcaacaugaauacauaguguugcaaggcgaacgaggggaagugaaacaucucaguacccuuaggaaaagaaaucaauugagauucccucaguagcggcgagcgaacggggaucagcccauuaaguuauguguguuuuaguggaacgcucugggaagugcgaacguagagggugauauucccguacacgaaagggcacacauaaugaugacgaguagggcgaggcacgugaaaccuugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccugugaggggagugaaauagauccugaaaccgcaugcauacaagcagugggagcaccuucguggugugacugcguaccuuuuguauaaugggucagcgacuuauauucaguagcgagguuaaccguauaggggagccguagagaaaucgagucuuaauagggcguuuaguugcuggguauagacccgaaaccaggcgaucuauccaugagcagguugaagguuggguaacacuaacuggaggaccgaacccacugucguugaaaagccaggggaugacuuguggauaggggugaaaggcuaaucaagccuggugauagcugguucuccccgaaagcuauuuagguagcgccucggacgaauaccauaggggguagagcacuguuucggcuagggggucaucccgacuuaccaaaccgaugcaaacuccgaauaccuaugaguacuauccgggagacagacugcgggugcuaacguccguagucaagaggaaaacaauccagaccgccagcuaaggccccaaaaucauaguuaagugggaaacgaugugggaaggcauagacagcuaggagguuggcuuagaagcagccacccuuuaaagaaagcguaauagcucacuagucgagucggccugcgcggaagauguaacggggcuaaaacuaugugccgaagcugcggauguauacuuuguauacgugguaggggagcguucuguaagccgaugaagguguguugagaagcaugcuggagguaucagaagugcgaaugcugacgugaguaacgacaaaacgggugaaaaacccguucgccgaaagaccaaggguuccaguccaacguuaaucggggcugggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaaaugguuaauauuccauuacuucuguguaaugcgaugagaggacggagaaggcuaaaucagccuggcguugguuguccaggugaaaggauguaggcauguaucuuaggcaaauccgggguacucuaugcugagaucugauagcaagcuguacuuguacagcgaagugguugaugccaugcuuccaggaaaagucucuaagcuucaguuacacaggaaucguacccgaaaccgacacagguggucaggucgaguagaccaaggcgcuugagagaacucugcugaaggaacuaggcaaaaugguaccguaacuucgggagaagguacgcuguuguuggugauggaacucgcuuccugagcugacgacagccgcagaaaccaggccgcugcaacuguuuauuaaaaacauagcacucugcaaacacgaaaguggacguauagggugugaugccugcccggugcuggaagguuaauugaugggguuagcguaagcgaagcucuugaucgaagccccaguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgaccugcacgaauggcauaaugauggcggcgcugucuccagcagaggcucagugaaaucgaaaucgcugugnagaugcaguguacccgcggcuagacggaaagaccccgunaaccuuuacugcagcuugacacugaacuuugaccuuacuuguguaggauaggugggaggcuuugaagcuggaacgcuaguuccaguggagccguccuugaaauaccacccugguaauguugagguucuaacucugucccgugauccgggacgaggaccgugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggaguacgaaggugcgcucagcguggucggaaaucacgcguagaguauaaaggcaaaagcgcgcuuaacugcgagacccacaagucgagcagguacgaaaguaggucuuagugauccggugguucuguauggaagggccaucgcucaacggauaaaagguacucugnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgnugucggcucaucucauccuggggcugaagcaggucccaaggguauggcnguucgccauuuaaagagguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucuaccgugggcgcuggaaauuugagaggaucugcuccuaguacgagaggaccagaguggacgaaccucugguguaccgguugugacgccagucgcaucgccggguagcuauguucggaagggauaaccgcugaaagcaucuaagcgggaagccuaccucaagauaagauuucccuaggacuuuauguccucuaaagagccguucgagacuaggacguugauagguuggauguggaagcauagugauaugugaagcugaccaauacuaauugcucgugaggcuugacua <<<<<<<<......<<<<<<<<<<<....<<<.<<<<<<<<<<<<<<......<<<<<<....(((.>>>.....<<<<<<<..<<.)))......>>.....>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<......<<<<<<<<<<<<<<.<<<...<<<.<......>.>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>...........<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>>.>>>..............<<....>>....>>.........<<<<.....>>>>.............>....>>>>>>>>>>>.......<<<<..<<<<<.....>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>...>.>>>...<<<.<<<.<........>.>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<....<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<.......>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<.<<<<<<..<.........<<<<.........<.........>...............<<........>>...>>>>.....>..>>>>>>>>...........)))......>>>>>>.>>>...>>>>>>><<<<<<.......>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<...[[[[...>>>>>>....<<<<...<<<<<.<<<<<<.<<.....>>>>>>>>....>>>>>...>>>>...........<......>.........>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<....<....>.....>>>>><<<<<<<<<<<<...<<<<.....>>>>...>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<<.<<....>>..>>>>>>........>>>>>>>>..>>>>><<<<<.........>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<.<<<<.<<......<<<<.<<<<<<..<<<<..<<<.<<<<<.<<<<<<<<<<.<<<<<.............<.................<<........>>........................>....>>>>>.>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>...>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<.................>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<<<<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>...>>>>..>..>>>>>>>>. (((((((([.....((((((((((.....(((..(((((((((((((......((((((....[[[.))).....((((((...((.]]]......))......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.....((.((((((((..(.(((...(((.(......).)))[[(...).(((.....]])))...)))...)..)))))))).))......)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((..).)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((.(.......<).))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).(((((((...((((((((((.....(((....((.((((...((..((.......))...))...)))).))...)).).....)))))).))).).)))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(.(.......(((((.(.(...(............)...))........((........))..)))))...).)..))))).))...........]]].)....))))))))))...)))))))((((((((...))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]]((((((((((.((...((((....((((..(((..((((((((((((...{{{.).))))))....(((....((((..((.....((.....))....)).....))))..[.)))............................)))))...)))...))))(..).....))))...)).....)))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((...((((....]))))...))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((.(......).(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..(((((((..(((.((......(((..((((((..(((((.(((.(((((.(((((((.((..((((.(.....(.......[............(..(...........).)..........)........]....).))).).)).)))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...((.((.........)).)).....((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..)).)))........((..(.((((((...((.......))...))))))...).))..........(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(.(((((....))).)).)..>.))..))).)))))))[...(((((((...((((..((((((......(....).....)))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(..(((((..)])))).(....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))..).))))))))). Cryo-EM structure of the Acinetobacter baumannii Ribosome: 70S with P-site tRNA; 23s ribosomal RNA 6v39 B 115 3.04 RF00001 URS00002D8B10_470 31964740 0003735 0005840 470 gcuggcgaccauagcaagagugaaccaccugaucccuucccgaacucagaagugaaaccucuuagcgcugaugguagugugggauuacccaugugagaguaagucaucgccagcu <<<<<<<<.....<<<<<<<.....<<<.<<...............>>...>>>....>>>>>.>><<<.......<<<<<<<....>>>>>>>.......>>>..>>>>>>>>. ((((((((.....(((((((.....(((.......(.....).........)))....))))).))(((.......(((((((....))))))).......)))..)))))))). Cryo-EM structure of the Acinetobacter baumannii Ribosome: 70S with P-site tRNA; 5s ribosomal RNA 6v39 sN1 1528 3.04 RF00177,RF01959,RF01960 URS00007B6DEC_480119 31964740 0003735 0005840 480119 uaacugaagaguuugaucauggcucagauugaacgcuggcggcaggcuuaacacaugcaagucgagcgggggaagguagcuugcuaccggaccuagcggcggacgggugaguaaugcuuaggaaucugccuauuagugggggacaacaucucgaaagggaugcuaauaccgcauacguccuacgggagaaagcaggggaucuucggaccuugcgcuaauagaugagccuaagucggauuagcuaguuggugggguaaaggccuaccaaggcgacgaucuguagcgggucugagaggaugauccgccacacugggacugagacacggcccagacuccuacgggaggcagcaguggggaauauuggacaauggggggaacccugauccagccaugccgcgugugugaagaaggccuuaugguuguaaagcacuuuaagcgaggaggaggcuacucuaguuaauaccuagggauaguggacguuacucgcagaauaagcaccggcuaacucugugccagcagccncgguaauacagagggugcgagcguuaaucggauuuacugggcguaaagcgugcguaggcggcuuauuaagucggaugugaaauccccgagcuuaacuugggaauugcauucgauacuggugagcuagaguaugggagaggaugguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgauggcgaaggcagccaucuggccuaauacugacgcugagguacgaaagcauggggagcaaacaggauuagauacccugguaguccaugccguaaacgaugucuacuagccguuggggccuuugaggcuuuaguggcgcagcuaacgcgauaaguagaccgccuggggaguacggucgcaagacuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggccuugacauacuagaaacuuuccagagauggauuggugccuucgggaaucuagauacaggugcugcauggcugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuuuuccuuacuugccagcauuucggaugggaacuuuaaggauacugccagugacaaacuggaggaaggcggggacgacgucaagucaucaugncccuuacggccagggcuacacacgugcuacaauggucgguacaaaggguugcuacacagcgaugugaugcuaaucucaaaaagccgaucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucgcggaucagaaugccgcggugaauacguucccgggccuuguacacaccgnccgucacaccaugggaguuuguugcaccagaaguagcuagccuaacugcaaagagggcgguuaccacgguguggccgaugacuggggugaagucgnaacaagguagccguaggggnnccugcggcuggauc ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<<.......<....>.......>>>.>>>>>......<<.......<<<<<<<..<<...<<<<<<<<<.<<.....<<<<<<....>>>>>>......>>.>.....<<<....>>>....<<<<<<..<.....>.>>>>>>>>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<<<<<<<<<<.......>>>>>>.>>>>........>>>>>....>..<<<<<((....<<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<....<<<......>>>.......>>>>>>>...........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<.....>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<........<<<<<.....<..<....>.>.......<......>..>>>>>....<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<<..<<<.....>>>>>.....>>>>>>.....<<<<.......>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<...<<<<....>>>>...>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<.<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>.>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((....................))).)))))......(((......(((((((..((...(((((((((.((.....((((((....))))))......)).).....(((....)))....(((.((..........)).)))))))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(..((((((((((.......)))))).))))...)....)))))....)..((((([[....(((((.....((..]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((.(((.....))).))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((.(((.((..(((((..((((((((((......((........))..........(((((((..(....((((((..(..((.(....)).)..)....(....)...))))).).).((.(((...((((((.(....(((((((((....)))...(.(......).)...)))))).....(((..((((((....((..((.......)))).....))))))..(..(.((.......)).).....)...))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...))).)))))).))..(.(..((.(.((((.(((..(((.(((((.((....(((((..(((...((....))..))).)))))...)).))))).)))..))).))))..).))...)..)..(((((((((....)))))))))}.... Cryo-EM structure of the Acinetobacter baumannii Ribosome: 70S with P-site tRNA; 16s Ribosomal RNA 6v39 v 77 3.04 RF00005 URS00002D670D_480119 31964740 0030533 0006412 480119 ggcuaugnagcucaguuggnuagagcaccgcacucauaaugcgggggucacaagnucaagucucgucauagccacca <<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<.<<.......>>.>>>>>>>>>.... (((((((....((.........))...(((((.......))))).....((.((.......)).))))))))).... Cryo-EM structure of the Acinetobacter baumannii Ribosome: 70S with P-site tRNA; tRNA-met 6v3a AN1 2892 2.82 RF02540,RF02541 URS00000BF98D_480119 31964740 0003735 0005840 480119 agucaaguaauuaagugcaugugguggaugccuuggcagucagaggcgaugaaagacgugauagccugcgaaaagcuccggggaggcggcaaauauccuuugauccggagaugucugaaugggggaacccaccuacuuuaagguagguauugcaacaugaauacauaguguugcaaggcgaacgaggggaagugaaacaucucaguacccuuaggaaaagaaaucaauugagauucccucaguagcggcgagcgaacggggaucagcccauuaaguuauguguguuuuaguggaacgcucugggaagugcgaacguagagggugauauucccguacacgaaagggcacacauaaugaugacgaguagggcgaggcacgugaaaccuugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccugugaggggagugaaauagauccugaaaccgcaugcauacaagcagugggagcaccuucguggugugacugcguaccuuuuguauaaugggucagcgacuuauauucaguagcgagguuaaccguauaggggagccguagagaaaucgagucuuaauagggcguuuaguugcuggguauagacccgaaaccaggcgaucuauccaugagcagguugaagguuggguaacacuaacuggaggaccgaacccacugucguugaaaagccaggggaugacuuguggauaggggugaaaggcuaaucaagccuggugauagcugguucuccccgaaagcuauuuagguagcgccucggacgaauaccauaggggguagagcacuguuucggcuagggggucaucccgacuuaccaaaccgaugcaaacuccgaauaccuaugaguacuauccgggagacagacugcgggugcuaacguccguagucaagaggaaaacaauccagaccgccagcuaaggccccaaaaucauaguuaagugggaaacgaugugggaaggcauagacagcuaggagguuggcuuagaagcagccacccuuuaaagaaagcguaauagcucacuagucgagucggccugcgcggaagauguaacggggcuaaaacuaugugccgaagcugcggauguauacuuuguauacgugguaggggagcguucuguaagccgaugaagguguguugagaagcaugcuggagguaucagaagugcgaaugcugacgugaguaacgacaaaacgggugaaaaacccguucgccgaaagaccaaggguuccaguccaacguuaaucggggcugggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaaaugguuaauauuccauuacuucuguguaaugcgaugagaggacggagaaggcuaaaucagccuggcguugguuguccaggugaaaggauguaggcauguaucuuaggcaaauccgggguacucuaugcugagaucugauagcaagcuguacuuguacagcgaagugguugaugccaugcuuccaggaaaagucucuaagcuucaguuacacaggaaucguacccgaaaccgacacagguggucaggucgaguagaccaaggcgcuugagagaacucugcugaaggaacuaggcaaaaugguaccguaacuucgggagaagguacgcuguuguuggugauggaacucgcuuccugagcugacgacagccgcagaaaccaggccgcugcaacuguuuauuaaaaacauagcacucugcaaacacgaaaguggacguauagggugugaugccugcccggugcuggaagguuaauugaugggguuagcguaagcgaagcucuugaucgaagccccaguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgaccugcacgaauggcauaaugauggcggcgcugucuccagcagaggcucagugaaaucgaaaucgcugugnagaugcaguguacccgcggcuagacggaaagaccccgunaaccuuuacugcagcuugacacugaacuuugaccuuacuuguguaggauaggugggaggcuuugaagcuggaacgcuaguuccaguggagccguccuugaaauaccacccugguaauguugagguucuaacucugucccgugauccgggacgaggaccgugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggaguacgaaggugcgcucagcguggucggaaaucacgcguagaguauaaaggcaaaagcgcgcuuaacugcgagacccacaagucgagcagguacgaaaguaggucuuagugauccggugguucuguauggaagggccaucgcucaacggauaaaagguacucugnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgnugucggcucaucucauccuggggcugaagcaggucccaaggguauggcnguucgccauuuaaagagguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucuaccgugggcgcuggaaauuugagaggaucugcuccuaguacgagaggaccagaguggacgaaccucugguguaccgguugugacgccagucgcaucgccggguagcuauguucggaagggauaaccgcugaaagcaucuaagcgggaagccuaccucaagauaagauuucccuaggacuuuauguccucuaaagagccguucgagacuaggacguugauagguuggauguggaagcauagugauaugugaagcugaccaauacuaauugcucgugaggcuugacua <<<<<<<<......<<<<<<<<<<<....<<<.<<<<<<<<<<<<<<......<<<<<<....(((.>>>.....<<<<<<<..<<.)))......>>.....>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<......<<<<<<<<<<<<<<.<<<...<<<.<......>.>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>...........<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>>.>>>..............<<....>>....>>.........<<<<.....>>>>.............>....>>>>>>>>>>>.......<<<<..<<<<<.....>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<.<........>.>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<....<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<.......>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<.<<<<<<..<.........<<<<...<.....<.........>......>........<<........>>...>>>>.....>..>>>>>>>>...........)))......>>>>>>.>>>...>>>>>>><<<<<<<.....>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<...[[[[...>>>>>>....<<<<...<<<<<.<<<<<..<<.....>>.>>>>>....>>>>>...>>>>...........<......>.........>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<<<<<<<...<<<<.....>>>>...>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<<.<<....>>..>>>>>>........>>>>>>>>..>>>>><<<<<.........>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<.<<<<.<<......<<<<.<<<<<<..<<<<..<<<.<<<<<.<<<<<<<<<<.<<<<<............<<.....<........<................>.....>...............>>...>>>>>.>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>...>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<.................>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<<<<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>...>>>>..>..>>>>>>>>. .((((((([.....((((((((((.....(((..(((((((((((((......((((((....[[[.))).....((((((...((.]]]......))......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.....((.((((((((..(.(((...(((.(......).)))[[(...).(((.....]])))...)))...)..)))))))).))......)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((..).)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((.(........).))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).(((((((...((((((((((.....(((....((.((((...((..((.......))...))...)))).))...)).).....)))))).))).).)))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(.......{.(((((.(.(...(............)...))........((........))..))))).....)..))))).))...........]]].)....))))))))))...)))))))((((((((...))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]]((((((((((.((...((((....((((..(((..((((((((((((...{{{.).))))))....((((...((((..((...(.((.....)))...)).....))))..[))))............................)))))...)))...))))(..).....))))...)).....)))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((...((((....]))))...))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..(((((((..(((.((......(((..((((((..(((((.(((.(((((.(((((((.((..((((.(.....(.......[............(..(...........).)..........)........]....).))).).)).)))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...((.((.........)).)).....((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..)).)))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(.(((((....))).)).)....))..))).)))))))[...(((((((...((((..((((((......(....).....)))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(..(((((..)])))).(....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))..).)))))))).. Cryo-EM structure of the Acinetobacter baumannii Ribosome: 70S with E-site tRNA; 23s ribosomal RNA 6v3a B 115 2.82 RF00001 URS00002D8B10_470 31964740 0003735 0005840 470 gcuggcgaccauagcaagagugaaccaccugaucccuucccgaacucagaagugaaaccucuuagcgcugaugguagugugggauuacccaugugagaguaagucaucgccagcu <<<<<<<<.....<<<<<<<.....<<<.<<...............>>...>>>....>>>>>.>><<<.......<<<<<<<....>>>>>>>.......>>>..>>>>>>>>. ((((((((.....(((((((.....(((...(...(.....)...).....)))....))))).))(((.......(((((((....))))))).......)))..)))))))). Cryo-EM structure of the Acinetobacter baumannii Ribosome: 70S with E-site tRNA; 5s ribosomal RNA 6v3a sN1 1528 2.82 RF00177,RF01959,RF01960 URS00007B6DEC_470 31964740 0003735 0005840 470 uaacugaagaguuugaucauggcucagauugaacgcuggcggcaggcuuaacacaugcaagucgagcgggggaagguagcuugcuaccggaccuagcggcggacgggugaguaaugcuuaggaaucugccuauuagugggggacaacaucucgaaagggaugcuaauaccgcauacguccuacgggagaaagcaggggaucuucggaccuugcgcuaauagaugagccuaagucggauuagcuaguuggugggguaaaggccuaccaaggcgacgaucuguagcgggucugagaggaugauccgccacacugggacugagacacggcccagacuccuacgggaggcagcaguggggaauauuggacaauggggggaacccugauccagccaugccgcgugugugaagaaggccuuaugguuguaaagcacuuuaagcgaggaggaggcuacucuaguuaauaccuagggauaguggacguuacucgcagaauaagcaccggcuaacucugugccagcagccncgguaauacagagggugcgagcguuaaucggauuuacugggcguaaagcgugcguaggcggcuuauuaagucggaugugaaauccccgagcuuaacuugggaauugcauucgauacuggugagcuagaguaugggagaggaugguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgauggcgaaggcagccaucuggccuaauacugacgcugagguacgaaagcauggggagcaaacaggauuagauacccugguaguccaugccguaaacgaugucuacuagccguuggggccuuugaggcuuuaguggcgcagcuaacgcgauaaguagaccgccuggggaguacggucgcaagacuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggccuugacauacuagaaacuuuccagagauggauuggugccuucgggaaucuagauacaggugcugcauggcugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuuuuccuuacuugccagcauuucggaugggaacuuuaaggauacugccagugacaaacuggaggaaggcggggacgacgucaagucaucaugncccuuacggccagggcuacacacgugcuacaauggucgguacaaaggguugcuacacagcgaugugaugcuaaucucaaaaagccgaucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucgcggaucagaaugccgcggugaauacguucccgggccuuguacacaccgnccgucacaccaugggaguuuguugcaccagaaguagcuagccuaacugcaaagagggcgguuaccacgguguggccgaugacuggggugaagucgnaacaagguagccguaggggnnccugcggcuggauc ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<<.......<....>.......>>>.>>>>>......<<.......<<<<<<<..<<...<<<<<<<<<.<<.....<<<<<<....>>>>>>......>>.>.....<<<....>>>....<<<<<<..<.....>.>>>>>>>>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<<<<<<<<<<.......>>>>>>.>>>>........>>>>>....>..<<<<<((....<<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<....<<<......>>>.......>>>>>>>...........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<.....>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<.......<<<<<<.....<..<....>.>.......<......>..>>>>>.>..<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<<..<<<.....>>>>>.....>>>>>>.....<<<<.......>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<.<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>.>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((....................))).)))))......(((......(((((((..((...(((((((((.((.....((((((....))))))......)).).....(((....)))....(((.((..........)).)))))))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(..((((((((((.......)))))).))))...)....)))))....)..((((([[....(((((.....((..]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((.(((.....))).))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((.......((((((.....((.(....)).).......(....)...))))).)...((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....(((..((((((....((..(((.....))))).....))))))..(..((((.......)))).....)...))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((.(((((.((....(((((..(((...((....))..))).)))))...)).))))).)))..))).))))..).))...)..)..(((((((((....)))))))))}.... Cryo-EM structure of the Acinetobacter baumannii Ribosome: 70S with E-site tRNA; 16s Ribosomal RNA 6v3a v 77 2.82 RF00005 URS00002D670D_480119 31964740 0030533 0006412 480119 ggcuaugnagcucaguuggnuagagcaccgcacucauaaugcgggggucacaagnucaagucucgucauagccacca <<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<.<<.......>>.>>>>>>>>>.... (((((((..((((.........)))).(((((.......))))).....((.((.......)).))))))))).... Cryo-EM structure of the Acinetobacter baumannii Ribosome: 70S with E-site tRNA; tRNA-met 6v3b AN1 2892 2.91 RF02540,RF02541 URS00000BF98D_480119 31964740 0003735 0005840 480119 agucaaguaauuaagugcaugugguggaugccuuggcagucagaggcgaugaaagacgugauagccugcgaaaagcuccggggaggcggcaaauauccuuugauccggagaugucugaaugggggaacccaccuacuuuaagguagguauugcaacaugaauacauaguguugcaaggcgaacgaggggaagugaaacaucucaguacccuuaggaaaagaaaucaauugagauucccucaguagcggcgagcgaacggggaucagcccauuaaguuauguguguuuuaguggaacgcucugggaagugcgaacguagagggugauauucccguacacgaaagggcacacauaaugaugacgaguagggcgaggcacgugaaaccuugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccugugaggggagugaaauagauccugaaaccgcaugcauacaagcagugggagcaccuucguggugugacugcguaccuuuuguauaaugggucagcgacuuauauucaguagcgagguuaaccguauaggggagccguagagaaaucgagucuuaauagggcguuuaguugcuggguauagacccgaaaccaggcgaucuauccaugagcagguugaagguuggguaacacuaacuggaggaccgaacccacugucguugaaaagccaggggaugacuuguggauaggggugaaaggcuaaucaagccuggugauagcugguucuccccgaaagcuauuuagguagcgccucggacgaauaccauaggggguagagcacuguuucggcuagggggucaucccgacuuaccaaaccgaugcaaacuccgaauaccuaugaguacuauccgggagacagacugcgggugcuaacguccguagucaagaggaaaacaauccagaccgccagcuaaggccccaaaaucauaguuaagugggaaacgaugugggaaggcauagacagcuaggagguuggcuuagaagcagccacccuuuaaagaaagcguaauagcucacuagucgagucggccugcgcggaagauguaacggggcuaaaacuaugugccgaagcugcggauguauacuuuguauacgugguaggggagcguucuguaagccgaugaagguguguugagaagcaugcuggagguaucagaagugcgaaugcugacgugaguaacgacaaaacgggugaaaaacccguucgccgaaagaccaaggguuccaguccaacguuaaucggggcugggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaaaugguuaauauuccauuacuucuguguaaugcgaugagaggacggagaaggcuaaaucagccuggcguugguuguccaggugaaaggauguaggcauguaucuuaggcaaauccgggguacucuaugcugagaucugauagcaagcuguacuuguacagcgaagugguugaugccaugcuuccaggaaaagucucuaagcuucaguuacacaggaaucguacccgaaaccgacacagguggucaggucgaguagaccaaggcgcuugagagaacucugcugaaggaacuaggcaaaaugguaccguaacuucgggagaagguacgcuguuguuggugauggaacucgcuuccugagcugacgacagccgcagaaaccaggccgcugcaacuguuuauuaaaaacauagcacucugcaaacacgaaaguggacguauagggugugaugccugcccggugcuggaagguuaauugaugggguuagcguaagcgaagcucuugaucgaagccccaguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgaccugcacgaauggcauaaugauggcggcgcugucuccagcagaggcucagugaaaucgaaaucgcugugnagaugcaguguacccgcggcuagacggaaagaccccgunaaccuuuacugcagcuugacacugaacuuugaccuuacuuguguaggauaggugggaggcuuugaagcuggaacgcuaguuccaguggagccguccuugaaauaccacccugguaauguugagguucuaacucugucccgugauccgggacgaggaccgugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggaguacgaaggugcgcucagcguggucggaaaucacgcguagaguauaaaggcaaaagcgcgcuuaacugcgagacccacaagucgagcagguacgaaaguaggucuuagugauccggugguucuguauggaagggccaucgcucaacggauaaaagguacucugnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgnugucggcucaucucauccuggggcugaagcaggucccaaggguauggcnguucgccauuuaaagagguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucuaccgugggcgcuggaaauuugagaggaucugcuccuaguacgagaggaccagaguggacgaaccucugguguaccgguugugacgccagucgcaucgccggguagcuauguucggaagggauaaccgcugaaagcaucuaagcgggaagccuaccucaagauaagauuucccuaggacuuuauguccucuaaagagccguucgagacuaggacguugauagguuggauguggaagcauagugauaugugaagcugaccaauacuaauugcucgugaggcuugacua <<<<<<<<......<<<<<<<<<<<....<<<.<<<<<<<<<<<<<<......<<<<<<....(((.>>>.....<<<<<<<..<<.)))......>>.....>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<......<<<<<<<<<<<<<<.<<<...<<<.<......>.>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>...........<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>>.>>>..............<<....>>....>>.........<<<<.....>>>>.............>....>>>>>>>>>>>.......<<<<..<<<<<.....>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<.<........>.>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<....<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<.......>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<.<<<<<<..<.........<<<<...<.....<.........>......>........<<........>>...>>>>.....>..>>>>>>>>...........)))......>>>>>>.>>>...>>>>>>><<<<<<<.....>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<...[[[[...>>>>>>....<<<<...<<<<<.<<<<<..<<.....>>.>>>>>....>>>>>...>>>>...........<......>.........>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<<<<<<<...<<<<.....>>>>...>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<<.<<....>>..>>>>>>........>>>>>>>>..>>>>><<<<<.........>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<.<<<<.<<......<<<<.<<<<<<..<<<<..<<<.<<<<<.<<<<<<<<<<.<<<<<............<<.................<<........>>........................>>...>>>>>.>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>...>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<.................>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<<<<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>...>>>>..>..>>>>>>>>. .((((((([.....((((((((((.....(((..(((((((((((((......((((((....[[[.))).....((((((...((.]]]......))......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.....((.((((((((..(.(((...(((.(......).)))[[(...).(((.....]])))...)))...)..)))))))).))......)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((..).)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((.(.......<).))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).(((((((...((((((((((.....(((....((.((((...((..((.......))...))...)))).))...)).).....)))))).))).).)))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(.......{.(((((.(.(...(............)...))........(..........)..))))).....)..))))).))...........]]].)....))))))))))...)))))))((((((((...))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]]((((((((((.((...((((....((((..(((..((((((((((((...{{{.).))))))....((((...((((..((...(.((.....)))...)).....))))..[))))............................)))))...)))...))))(..).....))))...)).....)))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((...((((....]))))...))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..(((((((..(((.((......(((..((((((..(((((.(((.(((((.(((((((.((..((((.(.....(.......[............(..(...........).)..........)........]....).))).).)).)))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...((.((.........)).)).....((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..)).)))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(.(((((....))).)).)..>.))..))).)))))))[...(((((((...((((..((((((......(....).....)))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(..(((((..)])))).(....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))..).)))))))).. Cryo-EM structure of the Acinetobacter baumannii Ribosome: 70S in Empty state; 23s ribosomal RNA 6v3b B 115 2.91 RF00001 URS00002D8B10_470 31964740 0003735 0005840 470 gcuggcgaccauagcaagagugaaccaccugaucccuucccgaacucagaagugaaaccucuuagcgcugaugguagugugggauuacccaugugagaguaagucaucgccagcu <<<<<<<<.....<<<<<<<.....<<<.<<...............>>...>>>....>>>>>.>><<<.......<<<<<<<....>>>>>>>.......>>>..>>>>>>>>. ((((((((.....(((((((.....(((.......(.....).........)))....))))).))(((.......(((((((....))))))).......)))..)))))))). Cryo-EM structure of the Acinetobacter baumannii Ribosome: 70S in Empty state; 5s ribosomal RNA 6v3b sN1 1528 2.91 RF00177,RF01959,RF01960 URS00007B6DEC_480119 31964740 0003735 0005840 480119 uaacugaagaguuugaucauggcucagauugaacgcuggcggcaggcuuaacacaugcaagucgagcgggggaagguagcuugcuaccggaccuagcggcggacgggugaguaaugcuuaggaaucugccuauuagugggggacaacaucucgaaagggaugcuaauaccgcauacguccuacgggagaaagcaggggaucuucggaccuugcgcuaauagaugagccuaagucggauuagcuaguuggugggguaaaggccuaccaaggcgacgaucuguagcgggucugagaggaugauccgccacacugggacugagacacggcccagacuccuacgggaggcagcaguggggaauauuggacaauggggggaacccugauccagccaugccgcgugugugaagaaggccuuaugguuguaaagcacuuuaagcgaggaggaggcuacucuaguuaauaccuagggauaguggacguuacucgcagaauaagcaccggcuaacucugugccagcagccncgguaauacagagggugcgagcguuaaucggauuuacugggcguaaagcgugcguaggcggcuuauuaagucggaugugaaauccccgagcuuaacuugggaauugcauucgauacuggugagcuagaguaugggagaggaugguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgauggcgaaggcagccaucuggccuaauacugacgcugagguacgaaagcauggggagcaaacaggauuagauacccugguaguccaugccguaaacgaugucuacuagccguuggggccuuugaggcuuuaguggcgcagcuaacgcgauaaguagaccgccuggggaguacggucgcaagacuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggccuugacauacuagaaacuuuccagagauggauuggugccuucgggaaucuagauacaggugcugcauggcugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuuuuccuuacuugccagcauuucggaugggaacuuuaaggauacugccagugacaaacuggaggaaggcggggacgacgucaagucaucaugncccuuacggccagggcuacacacgugcuacaauggucgguacaaaggguugcuacacagcgaugugaugcuaaucucaaaaagccgaucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucgcggaucagaaugccgcggugaauacguucccgggccuuguacacaccgnccgucacaccaugggaguuuguugcaccagaaguagcuagccuaacugcaaagagggcgguuaccacgguguggccgaugacuggggugaagucgnaacaagguagccguaggggnnccugcggcuggauc ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<<.......<....>.......>>>.>>>>>......<<.......<<<<<<<..<<...<<<<<<<<<.<<.....<<<<<<....>>>>>>......>>.>.....<<<....>>>....<<<<<<..<.....>.>>>>>>>>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<<<<<<<<<<.......>>>>>>.>>>>........>>>>>....>..<<<<<((....<<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<....<<<......>>>.......>>>>>>>...........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<.....>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<.......<<<<<<.....<..<....>..>......<......>..>>>>>.>..<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<<..<<<.....>>>>>.....>>>>>>.....<<<<.......>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<...<<<<.<<<..<<<.<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>.>>>..>>>.>>>>....>>...>.....<<<<<<<<<....>>>>>>>>>..... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((....................))).)))))......(((......(((((((..((...(((((((((.((.....((((((....))))))......)).).....(((....)))....(((.((..........)).)))))))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(..((((((((((.......)))))).))))...)....)))))....)..((((([[....(((((.....(...]].).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((.(((.....))).))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((.......((((((..(..((.......).)..)....(....)...))))).)...((.(((...((((((.(....(((((((((....)))..((((......))))..)))))).....(((..((((((....((..((.......)))).....))))))..(..((((.......)))).....)...))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((.(((((.((....(((((..((((..((....)).)))).)))))...)).))))).)))..))).))))..).))...)..)..(((((((((....)))))))))}.... Cryo-EM structure of the Acinetobacter baumannii Ribosome: 70S in Empty state; 16s Ribosomal RNA 6v3d AN1 2892 2.95 RF02540,RF02541 URS00000BF98D_480119 31964740 0003735 0005840 480119 agucaaguaauuaagugcaugugguggaugccuuggcagucagaggcgaugaaagacgugauagccugcgaaaagcuccggggaggcggcaaauauccuuugauccggagaugucugaaugggggaacccaccuacuuuaagguagguauugcaacaugaauacauaguguugcaaggcgaacgaggggaagugaaacaucucaguacccuuaggaaaagaaaucaauugagauucccucaguagcggcgagcgaacggggaucagcccauuaaguuauguguguuuuaguggaacgcucugggaagugcgaacguagagggugauauucccguacacgaaagggcacacauaaugaugacgaguagggcgaggcacgugaaaccuugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccugugaggggagugaaauagauccugaaaccgcaugcauacaagcagugggagcaccuucguggugugacugcguaccuuuuguauaaugggucagcgacuuauauucaguagcgagguuaaccguauaggggagccguagagaaaucgagucuuaauagggcguuuaguugcuggguauagacccgaaaccaggcgaucuauccaugagcagguugaagguuggguaacacuaacuggaggaccgaacccacugucguugaaaagccaggggaugacuuguggauaggggugaaaggcuaaucaagccuggugauagcugguucuccccgaaagcuauuuagguagcgccucggacgaauaccauaggggguagagcacuguuucggcuagggggucaucccgacuuaccaaaccgaugcaaacuccgaauaccuaugaguacuauccgggagacagacugcgggugcuaacguccguagucaagaggaaaacaauccagaccgccagcuaaggccccaaaaucauaguuaagugggaaacgaugugggaaggcauagacagcuaggagguuggcuuagaagcagccacccuuuaaagaaagcguaauagcucacuagucgagucggccugcgcggaagauguaacggggcuaaaacuaugugccgaagcugcggauguauacuuuguauacgugguaggggagcguucuguaagccgaugaagguguguugagaagcaugcuggagguaucagaagugcgaaugcugacgugaguaacgacaaaacgggugaaaaacccguucgccgaaagaccaaggguuccaguccaacguuaaucggggcugggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaaaugguuaauauuccauuacuucuguguaaugcgaugagaggacggagaaggcuaaaucagccuggcguugguuguccaggugaaaggauguaggcauguaucuuaggcaaauccgggguacucuaugcugagaucugauagcaagcuguacuuguacagcgaagugguugaugccaugcuuccaggaaaagucucuaagcuucaguuacacaggaaucguacccgaaaccgacacagguggucaggucgaguagaccaaggcgcuugagagaacucugcugaaggaacuaggcaaaaugguaccguaacuucgggagaagguacgcuguuguuggugauggaacucgcuuccugagcugacgacagccgcagaaaccaggccgcugcaacuguuuauuaaaaacauagcacucugcaaacacgaaaguggacguauagggugugaugccugcccggugcuggaagguuaauugaugggguuagcguaagcgaagcucuugaucgaagccccaguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgaccugcacgaauggcauaaugauggcggcgcugucuccagcagaggcucagugaaaucgaaaucgcugugnagaugcaguguacccgcggcuagacggaaagaccccgunaaccuuuacugcagcuugacacugaacuuugaccuuacuuguguaggauaggugggaggcuuugaagcuggaacgcuaguuccaguggagccguccuugaaauaccacccugguaauguugagguucuaacucugucccgugauccgggacgaggaccgugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggaguacgaaggugcgcucagcguggucggaaaucacgcguagaguauaaaggcaaaagcgcgcuuaacugcgagacccacaagucgagcagguacgaaaguaggucuuagugauccggugguucuguauggaagggccaucgcucaacggauaaaagguacucugnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgnugucggcucaucucauccuggggcugaagcaggucccaaggguauggcnguucgccauuuaaagagguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucuaccgugggcgcuggaaauuugagaggaucugcuccuaguacgagaggaccagaguggacgaaccucugguguaccgguugugacgccagucgcaucgccggguagcuauguucggaagggauaaccgcugaaagcaucuaagcgggaagccuaccucaagauaagauuucccuaggacuuuauguccucuaaagagccguucgagacuaggacguugauagguuggauguggaagcauagugauaugugaagcugaccaauacuaauugcucgugaggcuugacua 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(((((((([.....((((((((((.....(((..(((((((((((((......((((((....[[[.))).....((((((...((.]]]......))......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.....((.((((((((..(.(((...(((.(......).)))[[(...).(((.....]])))...)))...)..)))))))).))......)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((..).)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((.(........).))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).(((((((...((((((((((.....(((....((.((((...((..((.......))...))...)))).))...)).).....)))))).))).).)))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(.......{.(((((.(.(...(............)...))........((........))..))))).....)..))))).))...........]]].)....))))))))))...)))))))((((((((...))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]]((((((((((.((...((((....((((..(((..((((((((((((...{{{.).))))))....((((...((((..((...(.((.....)))...)).....))))..[))))............................)))))...)))...))))(..).....))))...)).....)))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((...((((....]))))...))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..(((((((..(((.((......(((..((((((..(((((.(((.(((((.(((((((.((..((((.(.....(.......[............(..(...........).)..........)........]....).))).).)).)))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...((.((.........)).)).....((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..)).)))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(.(((((....))).)).)....))..))).)))))))[...(((((((...((((..((((((......(....).....)))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(..(((((..)])))).(....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))..).))))))))). Cryo-EM structure of the Acinetobacter baumannii Ribosome: 50S subunit; 23s ribosomal RNA 6v3d B 115 2.95 RF00001 URS00002D8B10_470 31964740 0003735 0005840 470 gcuggcgaccauagcaagagugaaccaccugaucccuucccgaacucagaagugaaaccucuuagcgcugaugguagugugggauuacccaugugagaguaagucaucgccagcu <<<<<<<<.....<<<<<<<.....<<<.<<...............>>...>>>....>>>>>.>><<<.......<<<<<<<....>>>>>>>.......>>>..>>>>>>>>. ((((((((.....(((((((.....(((.......(.....).........)))....))))).))(((.......(((((((....))))))).......)))..)))))))). Cryo-EM structure of the Acinetobacter baumannii Ribosome: 50S subunit; 5s ribosomal RNA 6v4x Z 27 3.2 RF00066 URS0001A16A97_9606 32029631 9606 uuacagcucuuuuagaauuugucuagu ........................... ......................(..). Cryo-EM structure of an active human histone pre-mRNA 3'-end processing machinery at 3.2 Angstrom resolution; U7 snRNA 6v4x Y 25 3.2 RF00032 URS0002335991_10090 32029631 0006398 10090 cacugaaucagauaaagagcuguaa ......................... ......................... Cryo-EM structure of an active human histone pre-mRNA 3'-end processing machinery at 3.2 Angstrom resolution; modified H2a pre-mRNA 6v9b B 28 2.4 URS0001A24B55_32630 32386573 32630 aucgagggaguggugaggaugaggcgau ............................ ............................ Co-crystal structure of the fluorogenic Mango-IV homodimer bound to TO1-Biotin; RNA (28-MER) 6v9b D 27 2.4 URS0001A24B55_32630 32386573 32630 aucgagggaguggugaggaugaggcga ........................... ........................... Co-crystal structure of the fluorogenic Mango-IV homodimer bound to TO1-Biotin; RNA (28-MER) 6v9d B 28 2.8 URS0001A24B55_32630 32386573 32630 aucgagggaguggugaggaugaggcgau ............................ ............................ Co-crystal structure of the fluorogenic Mango-IV homodimer bound to TO1-Biotin; RNA (28-MER) 6v9d E 27 2.8 URS0001A24B55_32630 32386573 32630 aucgagggaguggugaggaugaggcga ........................... ........................... Co-crystal structure of the fluorogenic Mango-IV homodimer bound to TO1-Biotin; RNA (28-MER) 6va1 A 11 NA URS0001A24B6B_9606 32364710 9606 ccggcagugug ........... ........... Solution Structure of the Tau pre-mRNA Exon 10 Splicing Regulatory Element; RNA (5'-R(*CP*CP*GP*GP*CP*AP*GP*UP*GP*UP*G)-3') 6va1 B 10 NA URS0001A24B6C_9606 32364710 9606 cacacgucgg .......... .......... Solution Structure of the Tau pre-mRNA Exon 10 Splicing Regulatory Element; RNA (5'-R(*CP*AP*CP*AP*CP*GP*UP*CP*GP*G)-3') 6va2 A 11 NA URS0001A24B6B_9606 32364710 9606 ccggcagugug ........... ........... Solution Structure of the Tau pre-mRNA Exon 10 Splicing Regulatory Element Bound to MH5; RNA (5'-R(*CP*CP*GP*GP*CP*AP*GP*UP*GP*UP*G)-3') 6va2 B 10 NA URS0001A24B6C_9606 32364710 9606 cacacgucgg .......... .......... Solution Structure of the Tau pre-mRNA Exon 10 Splicing Regulatory Element Bound to MH5; RNA (5'-R(*CP*AP*CP*AP*CP*GP*UP*CP*GP*G)-3') 6va3 A 11 NA URS0001A24B6B_9606 32364710 9606 ccggcagugug ........... ........... Solution Structure of the Tau pre-mRNA Exon 10 Splicing Regulatory Element Bound to MQC; RNA (5'-R(*CP*CP*GP*GP*CP*AP*GP*UP*GP*UP*G)-3') 6va3 B 10 NA URS0001A24B6C_9606 32364710 9606 cacacgucgg .......... .......... Solution Structure of the Tau pre-mRNA Exon 10 Splicing Regulatory Element Bound to MQC; RNA (5'-R(*CP*AP*CP*AP*CP*GP*UP*CP*GP*G)-3') 6va4 A 11 NA URS0001A24B6B_9606 32364710 9606 ccggcagugug ........... ........... Solution Structure of the Tau pre-mRNA Exon 10 Splicing Regulatory Element Bound to MIP; RNA (5'-R(*CP*CP*GP*GP*CP*AP*GP*UP*GP*UP*G)-3') 6va4 B 10 NA URS0001A24B6C_9606 32364710 9606 cacacgucgg .......... .......... Solution Structure of the Tau pre-mRNA Exon 10 Splicing Regulatory Element Bound to MIP; RNA (5'-R(*CP*AP*CP*AP*CP*GP*UP*CP*GP*G)-3') 6vff C 32 2.8 URS0001A24B47_9606 32597966 9606 gcucgcgaugcungagggcucugauagcuacg ................................ ................................ Dimer of Human Adenosine Deaminase Acting on dsRNA (ADAR2) mutant E488Q bound to dsRNA sequence derived from human GLI1 gene; RNA (5-R(*GP*CP*UP*CP*GP*CP*GP*AP*UP*GP*CP*UP*(8AZ)P*GP*AP*GP*GP*GP*CP* UP*CP*UP*GP*AP*UP*AP*GP*CP*UP*AP*CP*G)-3) 6vff D 32 2.8 URS0001A24B51_9606 32597966 9606 cguagcuaucagagccccccagcaucgcgagc ................................ ................................ Dimer of Human Adenosine Deaminase Acting on dsRNA (ADAR2) mutant E488Q bound to dsRNA sequence derived from human GLI1 gene; RNA(5-R(*CP*GP*UP*AP*GP*CP*UP*AP*UP*CP*AP*GP*AP*GP*CP*CP*CP*CP*CP*CP*AP*GP*CP*AP*UP*CP*GP*CP*GP*AP*GP*C)-3) 6vlz AA 944 2.97 RF00177 URS000044DFF6_9606 32737313 0003735 0005840 9606 auagguuugguccuagccuuucuauuagcucuuaguaagauuacacaugcaagcauccccguuccagugaguucacccucuaaaucaccacgaucaaaaggaacaagcaucaagcacgcagcaaugcagcucaaaacgcuuagccuagccacacccccacgggaaacagcagugauuaaccuuuagcaauaaacgaaaguuuaacuaagcuauacuaaccccaggguuggucaauuucgugccagccaccgcggucacacgauuaacccaagucaauagaagccggcguaaagaguguuuuagaucacccccaauaaagcuaaaacucaccugaguuguaaaaaacuccaguugacacaaaauagacuacgaaaguggcuuuaacauaucugaacacacaauagcuaagacccaaacugggauuagauaccccacuaugcuuagcccuaaaccucaacaguuaaaucaacaaaacugcucgccagaacacuacgagccacagcuuaaaacucaaaggaccuggcggugcuucauaucccucuagaggagccuguucuguaaucgauaaaccccgaucaaccucaccaccucuugcucagccuauauaccgccaucuucagcaaacccugaugaaggcuacaaaguaagcgcaaguacccacguaaagacguuaggucaagguguagcccaugagguggcaagaaaugggcuacauuuucuaccccagaaacgauagcccuuaugaaacuuaagggucgaagguggauuuagcaguaaacuaagaguagagugcuuaguugaacagggcccugaagcgcguacacaccgcccgucacccuccucaaguauacuucaaaggacauuuaacuaaaaccccuacgcauuuauauagaggagacaagucguaacaugguaaguguacuggaaagugcacuuggacgaac ..((((..<<<<<<.)))).<<<<<<.....<<<<<<<<..<.<<<.<<<..<......>......<<........<<<....<<<.....>>>....>>>...<<<<....<<<..<<<....>>>.>>>......>>>>.<<...>>.>>.<<<....>>>.....>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>.....<<<<<<<<.....(((.....((.>>>)).......)))..>>>>>.....>>>>>>....<<<((.....<<<<..<<<<..........<<<<<<......<<<.<<<.<<<......>>>..>>>.>>>............<<<....>>>>>>>>>.....>>>>...>>>>...<<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..>.......<.<<<<<......))..>>>>>.>.>>>.<<.......<<<<....>>>>.....>>..>>>>>><<<<<.<<<<<<<...<<<.<<<<...<<<<<<<<<<.....<<........>>..........<<<<<<<.......<<.<<<..<<<<<<.......<<..<<<<<.....>>>.......>>..>>.....<<<....>>>.........>>>...>>>>>>>>....>>>>>>>..>>.>>>>>>>>.....<<<<.....>>>>.......<<<<<.........>>>>>............>>>>.....<<<<<<<.........>>>>>>>.....>>>...>>>>>>>>>>.>>.......<<.<...<<<<<<..<<<<<..<..........<.......>..........>..>>>>>.>>>>>>....>.>>.........<<<<<<<<<....>>>>>>>>>........ [.[[[[..((((((.]]]]]((((((.((..((((((((..(.(((.(((..(......)......(((.......(((.(..(((.....))).)..)))...((((....((..((((....))).)))......)))).((...))))).(((....))).....)))))))......(.(((...(((((....)))).))))).)).)))))).....((((([[[.....(((.....((.]]])).......)))..)))))..).)))))))....((([[...(.((((...(((..........(((((((.....(((.(((.(((......)))..))).))).....).....(.((....))))))))).....)))....))))....((((((...((...((((.........))))...))))))))......{...(.(((((......]]..))))).))))).(.(......((((....)))).....))..))))))((.((.(((((((...(((.(((.(..(((((((.((.....((........))..........(((((((.......((.(((...((((((.(....((..(((((.....))).......))..)).....(((....))).....).).)))...)).)))))....)))))))..))..))))))).(....(((.....)))..(....((((((.........))))).)....).)..).))).....(((((((.........))))))).....)))...)))))))))..))..(.(..((.(...((((((..(((((..((....(....(.......)...)....).)..))))).))))))....).))...)..)..(((((.(((....))).)))))}....... Structure of the human mitochondrial ribosome-EF-G1 complex (ClassI); 12s rRNA 6vlz A 1527 2.97 RF02541,RF02540 URS000080E357_9606 32737313 0003735 0005840 9606 gcuaaaccuagccccaaacccacuccaccuuacuaccagacaaccuuagccaaaccauuuacccaaauaaaguauaggcgauagaaauugaaaccuggcgcaauagauauaguaccgcaagggaaagaugaaaaauuauaaccaagcauaauauagcaaggacuaaccccuauaccuucugcauaaugaauuaacuagaaauaacuuugcaaggagagccaaagcuaagacccccgaaaccagacgagcuaccuaagaacagcuaaaagagcacacccgucuauguagcaaaauagugggaagauuuauagguagaggcgacaaaccuaccgagccuggugauagcugguuguccaagauagaaucuuaguucaacuuuaaauuugcccacagaacccucuaaauccccuuguaaauuuaacuguuaguccaaagaggaacagcucuuuggacacuaggaaaaaaccuuguagagagaguaaaaaauuuaacacccauaguaggccuaaaagcagccaccaauuaagaaagcguucaagcucaacacccacuaccuaaaaaaucccaaacauauaacugaacuccucacacccaauuggaccaaucuaucacccuauagaagaacuaauguuaguauaaguaacaugaaaacauucuccuccgcauaagccugcgucagauuaaaacacugaacugacaauuaacagcccaauaucuacaaucaaccaacaagucauuauuacccucacugucaacccaacacaggcaugcucauaaggaaagguuaaaaaaaguaaaaggaacucggcaaaucuuaccccgccuguuuaccaaaaacaucaccucuagcaucaccaguauuagaggcaccgccugcccagugacacauguuuaacggccgcgguacccuaaccgugcaaagguagcauaaucacuuguuccuuaaauagggaccuguaugaauggcuccacgaggguucagcugucucuuacuuuuaaccagugaaauugaccugcccgugaagaggcgggcauaacacagcaagacgagaagacccuauggagcuuuaauuuauuaaugcaaacaguauaccaaaccugcauuaaaaauuucgguuggggcgaccucggagcagaacccaaccuccgagcaguacaugcuaagacuucaccagucaaagcgaaccucaauugauccaauaacuugaccaacggaacaaguuacccuagggauaacagcgcaauccuauucuagaguccauaucaacaauaggguuuacgaccucgauguuggaucaggacaucccgauggugcagccgcuauuaaagguucguuuguucaacgauuaaaguccuacgugaucugaguucagaccggaguaauccaggucgguuucuaucuacuuucaaauuccucccuguacgaaaggacaagagaaauaaggccuacuucacaaagcgccuucccccguaaaugauaucaucucaacuuaguauuauacccacacccacccaagaacaggguuu <<<.......<<<<.....................................<......>.........<.....<<.....>>....>........>>.>>.............<<....>>......................>>>...........<<<.......>>>...<.<........>.>.<<<<<<.........<<<.<<..<<....>>...>>.>>>...<<.<..<<<<<.<.....<<<<<.<<<..<<<.....>>>...<<<..<<<<........>>>>.>>>....>>>.>>>>>...<<.......>>......>.>>>>...>..>.>>..<<<<<<....<<<<....>>>><<<.<<<<<<<<<<.....<<..........>>.....>>>>>>>>>>..>>>.<<<<<<<<<<......>>>>>>>>>>...<<<......>>>....<<<.<<<...<..............<.....<<.........>>.....>.......<<<......>>>....................................>...>>>>>>........>>>>>>...<<<<<......>>>>>.........>>>>>><......<<..<<<....>>><<<<..<<<<........<<<<<..............>>>>>......<<<...<<<<.......................>>>>.......>>>.....<<......>>.>>>>.....>>>>..<<<<...<<<<<<<<.<<................<<<<<<..<<<.........>>>...<<<<<<.............>>>>>>....<<<.<<<..<<<<<....>>>..>>>>><<<<<<......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>....>>.>>>>........>>.>>>>>>>>>>>>.>>.....>.....<<<<<........>>>>>.......<<..<<<.<<......<<<<.<<<<<<..<<<<..<<<<<<<<.....<..>.......>>>>>>>>.>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<......<<<..<<<<.....>>>>..>>>.....>.........<<<....>>>............>>>>..>>>>>>.......<<<..<<<<<<<<...<<.......>>...>>>>>>>..>.>>.>.......<.<<<.<<<<<<..<<.<<<<<<......>>>>>>...>>.<<<<<.....>>>>>.....>>>>>..>...>>>..>....<<<<<<<....>>>.>>>>....>>..>>>.>>...<.<<<.<<<.................>>>.>>><<<<<...<<<....>>>.>>>>>......<<<................>>>......>..........<<<<.......>>>>.. ((.....(..((((.....................................(...[..).........(.....((.]...))....)........)).)).............((....))....)..................)).........(.(((.......))).[.(.(........).).(.((((.........(((.((..((....))...)).)))...((.(...((((.(.....(((((.((((.(((....[)))...(((..((((.......{)))).)))..).))).))))).(.((.......))...)..).))))......).))..((((((....((((....)))).((..(((((((((.....((..........)).....)))))))))...))..((((((((((......))))))))))...(((......)))....(((.(((...(..............(.(...((.........))...).)....(..(((......))))...................................)...))))))........))))))...(((((......))))).........)))).)(......((..(((....)))(((...((((......(.(((((.....(....)...)))))......(((...((((...............(..)....)))).......))).)...((......)).))))......)))..((((....(((((((.((..(.............((((((.].((.........))....((((((.............))))))....(((.(((..(((((....)))..)))))(((((........)))))........((..........((((((.....))))))..)..)....)))....)).)))).......))).))))))).)))).)).....)).{..(((((.....]}.))))).......((..(((.((......((((.((((((..(((((..(((((((....(.()..).....))))))).)))))..(((......[)))((((((..........]))))))(.(......(((..(((....[..)))..))).....)..........((....))......)].....))))..))))))......((((..(.((((((.(.((.......)))..))))))...).)).).)......((((.((((((..((..((.((......)).))....)).((((.(....))))).....)))))..)...))).).....(((((((....))).))))..}.))..))).))...(.(((.(((......(....).....))).)))(((((...(((....))).)))))......(((................)))......)..........((((.......)))).. Structure of the human mitochondrial ribosome-EF-G1 complex (ClassI); 16s rRNA 6vmi AA 944 2.96 RF00177 URS000044DFF6_9606 32737313 0003735 0005840 9606 auagguuugguccuagccuuucuauuagcucuuaguaagauuacacaugcaagcauccccguuccagugaguucacccucuaaaucaccacgaucaaaaggaacaagcaucaagcacgcagcaaugcagcucaaaacgcuuagccuagccacacccccacgggaaacagcagugauuaaccuuuagcaauaaacgaaaguuuaacuaagcuauacuaaccccaggguuggucaauuucgugccagccaccgcggucacacgauuaacccaagucaauagaagccggcguaaagaguguuuuagaucacccccaauaaagcuaaaacucaccugaguuguaaaaaacuccaguugacacaaaauagacuacgaaaguggcuuuaacauaucugaacacacaauagcuaagacccaaacugggauuagauaccccacuaugcuuagcccuaaaccucaacaguuaaaucaacaaaacugcucgccagaacacuacgagccacagcuuaaaacucaaaggaccuggcggugcuucauaucccucuagaggagccuguucuguaaucgauaaaccccgaucaaccucaccaccucuugcucagccuauauaccgccaucuucagcaaacccugaugaaggcuacaaaguaagcgcaaguacccacguaaagacguuaggucaagguguagcccaugagguggcaagaaaugggcuacauuuucuaccccagaaacgauagcccuuaugaaacuuaagggucgaagguggauuuagcaguaaacuaagaguagagugcuuaguugaacagggcccugaagcgcguacacaccgcccgucacccuccucaaguauacuucaaaggacauuuaacuaaaaccccuacgcauuuauauagaggagacaagucguaacaugguaaguguacuggaaagugcacuuggacgaac ..((((..<<<<<..)))).<<<<<<.<...<<<<<<<<..<.<<<.<<<................<<........<<<.<..<<<.....>>>.>..>>>...<<<<....<<<..<<<....>>>.>>>......>>>>.<<...>>.>>.<<<....>>>.....>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>.....<<<<<<<<.....(((.....((.>>>)).......)))..>>>>>...>.>>>>>>....<<<((.....<<<<..<<<<..........<<<<<<......<<<.<<<.<<<......>>>..>>>.>>>.............<<....>>.>>>>>>.....>>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<.<<<<<......))..>>>>>.>.>>>.<<.......<<<<....>>>>.....>>...>>>>><<<<<.<<<<<<<...<<<.<<<<<..<<<<<<<<<<.....<<........>>..........<<<<<<<.......<<.<<<..<<<<<<<......<<....<<<.....>>>...........>>.....<<<....>>>.......>.>>>...>>>>>>>>....>>>>>>>..>>.>>>>>>>>.....<<<<.....>>>>......<<<<<<.........>>>>>>..........>>>>>.....<<<<<<<.........>>>>>>>.....>>>...>>>>>>>>>>.>>.......<<.<...<<<<<<..<<<<<.............<.......>.............>>>>>.>>>>>>....>.>>.........<<<<<<<<<....>>>>>>>>>........ [.[[[[..((((((.]]]]]((((((.((..((((((((..(.(((.(((..(......)......(((.......(((.(..((.......)).)..)))...((((....((..((((....))).)))......)))).((...))))).(((....))).....)))))))......(.(((...(((((....)))).))))).)).)))))).....((((([[[.....(((.....((.]]])).......)))..)))))..).)))))))....((([[...(.((((...(((..........(((((((.....(((.(((.(((......)))..))).))).....).....(.((....))))))))).....)))....))))....((((((...((...((((.........))))...))))))))......{...(.(((((......]]..))))).))))).((.......((((....)))).....))..))))))((.((..((((((...(((.(((.(..(((((.(.((.....((........))..........(((((((.......((.(((...((((((.(....((...((((.....))).......)...)).....(((....))).....).).)))...)).)))))....)))))))..))..).))))).(...((((.....)))).(....((((((.........))))).)....).)..).))).....(((((((.........))))))).....)))...)))))).))..))..(.(..((.(...((((((..(((((..((....(....(.......)...)....).)..))))).))))))....).))...)..)..(((((((((....)))))))))}....... Structure of the human mitochondrial ribosome-EF-G1 complex (ClassIII); 12s rRNA 6vmi A 1527 2.96 RF02541,RF02540 URS000080E357_9606 32737313 0003735 0005840 9606 gcuaaaccuagccccaaacccacuccaccuuacuaccagacaaccuuagccaaaccauuuacccaaauaaaguauaggcgauagaaauugaaaccuggcgcaauagauauaguaccgcaagggaaagaugaaaaauuauaaccaagcauaauauagcaaggacuaaccccuauaccuucugcauaaugaauuaacuagaaauaacuuugcaaggagagccaaagcuaagacccccgaaaccagacgagcuaccuaagaacagcuaaaagagcacacccgucuauguagcaaaauagugggaagauuuauagguagaggcgacaaaccuaccgagccuggugauagcugguuguccaagauagaaucuuaguucaacuuuaaauuugcccacagaacccucuaaauccccuuguaaauuuaacuguuaguccaaagaggaacagcucuuuggacacuaggaaaaaaccuuguagagagaguaaaaaauuuaacacccauaguaggccuaaaagcagccaccaauuaagaaagcguucaagcucaacacccacuaccuaaaaaaucccaaacauauaacugaacuccucacacccaauuggaccaaucuaucacccuauagaagaacuaauguuaguauaaguaacaugaaaacauucuccuccgcauaagccugcgucagauuaaaacacugaacugacaauuaacagcccaauaucuacaaucaaccaacaagucauuauuacccucacugucaacccaacacaggcaugcucauaaggaaagguuaaaaaaaguaaaaggaacucggcaaaucuuaccccgccuguuuaccaaaaacaucaccucuagcaucaccaguauuagaggcaccgccugcccagugacacauguuuaacggccgcgguacccuaaccgugcaaagguagcauaaucacuuguuccuuaaauagggaccuguaugaauggcuccacgaggguucagcugucucuuacuuuuaaccagugaaauugaccugcccgugaagaggcgggcauaacacagcaagacgagaagacccuauggagcuuuaauuuauuaaugcaaacaguauaccaaaccugcauuaaaaauuucgguuggggcgaccucggagcagaacccaaccuccgagcaguacaugcuaagacuucaccagucaaagcgaaccucaauugauccaauaacuugaccaacggaacaaguuacccuagggauaacagcgcaauccuauucuagaguccauaucaacaauaggguuuacgaccucgauguuggaucaggacaucccgauggugcagccgcuauuaaagguucguuuguucaacgauuaaaguccuacgugaucugaguucagaccggaguaauccaggucgguuucuaucuacuuucaaauuccucccuguacgaaaggacaagagaaauaaggccuacuucacaaagcgccuucccccguaaaugauaucaucucaacuuaguauuauacccacacccacccaagaacaggguuu <<<.......<<<<.....................................<......>.........<.....<<.....>>....>........>>.>>.............<<....>>......................>>>...........<<<.......>>>...<.<........>.>.<<<<<<.........<<<.<<..<<....>>...>>.>>>...<<.<..<<<<<.<.....<<<<<.<<<..<<.......>>...<<<..<<<<........>>>>.>>>....>>>.>>>>>...<<.......>>......>.>>>>...>..>.>>..<<<<<<....<<<<....>>>><<<.<<<<<<<<<<.....<<..........>>.....>>>>>>>>>>..>>>.<<<<<<<<<<......>>>>>>>>>>...<<<......>>>....<<<.<<<...<..............<.....<<.........>>.....>.......<<<......>>>....................................>...>>>>>>........>>>>>>...<<<<<......>>>>>.........>>>>>><......<<..<<<....>>><<<<..<<<<........<<<<<..............>>>>>......<<<...<<<<.......................>>>>.......>>>.....<<......>>.>>>>.....>>>>..<<<<...<<<<<<<<.<<................<<<<<<..<<<.........>>>...<<<<<<.............>>>>>>....<<<.<<<..<<<<<....>>>..>>>>><<<<<<......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>....>>.>>>>........>>.>>>>>>>>>>>>.>>.....>.....<<<<<........>>>>>.......<<..<<<.<<......<<<<.<<<<<<..<<<<..<<<<<<<<.....<..>.......>>>>>>>>.>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<......<<<..<<<<.....>>>>..>>>.....>.........<<<....>>>............>>>>..>>>>>>.......<<<...<<<<<<<...<<.......>>...>>>>>>>....>>.>.......<.<<<.<<<<<<..<<.<<<<<<......>>>>>>...>>.<<<<<.....>>>>>.....>>>>>..>...>>>..>....<<<<<<<....>>>.>>>>....>>..>>>.>>...<.<<<.<<<.................>>>.>>><<<<<...<<<....>>>.>>>>>......<<<................>>>......>..........<<<<.......>>>>.. ((.....(..((((.....................................(...[..).........(.....((.]...))....)........)).)).............((....))....)..................)).........(.(((.......))).[.(.(........).).(.((((.........(((.((..((....))...)).)))...((.(...((((.(.....(((((.((((.(((....[)))...(((..((((.......{)))).)))..).))).))))).(.((.......))...)..).))))......).))..((((((....((((....)))).((..(((((((((.....((..........)).....)))))))))...))..((((((((((......))))))))))...(((......)))....(((.(((...(..............(.(...((.........))...).)....(..(((......))))...................................)...))))))........))))))...(((((......))))).........)))).)(......((..(((....)))(((...((((......(.(((((.....(....)...)))))......(((...((((...............(..)....)))).......))).)...((......)).))))......)))..((((....(((((((.((..(.............((((((.].((.........))....((((((.............))))))....(((.(((..(((((....)))..)))))(((((........)))))........((..........((((((.....))))))..)..)....)))....)).)))).......))).))))))).)))).)).....)).{..(((((.....]}.))))).......((..(((.((......((((.((((((..(((((..(((((((....(.()..).....))))))).)))))..(((......[)))((((((..........]))))))(.(......(((..(((....[..)))..))).....).........(((....))).....)].....))))..))))))......((((..(.((((((.(.((.......)))..))))))...).)).).)......((((.((((((..((..((.((......)).))....)).((((.(....))))).....)))))..)...))).).....(((((((....))).))))..}.))..))).))...(.(((.(((......(....).....))).)))(((((...(((....))).)))))......(((................)))......)..........((((.......)))).. Structure of the human mitochondrial ribosome-EF-G1 complex (ClassIII); 16s rRNA 6vrd B 20 1.299 URS00021ED8FD_9606 9606 uggcgagugggugagugagg .................... .................... Crystal structure of RNase H/RNA/PS-ASO complex at an atomic level; RNA (5'-R(*UP*GP*GP*CP*GP*AP*GP*UP*GP*GP*GP*UP*GP*AP*GP*UP*GP*AP*GP*G)-3') 6vu3 7 29 3.7 32820061 32630 auguuuuuuuuuuuugauuuggugagagg ............................. ............................. Cryo-EM structure of Escherichia coli transcription-translation complex A (TTC-A) containing mRNA with a 12 nt long spacer; mRNA with 12 nt long spacer 6vu3 A 76 3.7 RF00005 URS000080DFF5_562 32820061 0030533 0006412 562 cgcgggguggagcagccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((........)))).(((((.......))))).....(((((.......)))))))))))..... Cryo-EM structure of Escherichia coli transcription-translation complex A (TTC-A) containing mRNA with a 12 nt long spacer; E-site and A-site tRNA (fMet) 6vu3 B 76 3.7 RF00005 URS000080DFF5_562 32820061 0030533 0006412 562 cgcgggguggagcagccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<........>>>>.<<<<.........>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((........)))).(((...........))).....(((((.......)))))))))))..... Cryo-EM structure of Escherichia coli transcription-translation complex A (TTC-A) containing mRNA with a 12 nt long spacer; E-site and A-site tRNA (fMet) 6vu3 D 1524 3.7 RF00177,RF01959,RF01960 URS00000ABFE9_562 32820061 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccggccagcagcccgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgauaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgccguacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgaacaagguaaccguaggggccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<......>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>..<<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>>.<<<<<(((...<<<<<.......)))........>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<......>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<......<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>..>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>......<<..<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>....>>........<<<<<<<<<..>>>>>>>>>...... ........((((..[.[[[[.)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((........))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..........)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((((.......)))))))).....)....)))))....)..((((([[[...(((((....(..]]]).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))..]]]].](((((.(((((((.((..(((((..((((((((((......((......))..........(((((((..(...((.((((..(((.(((....))).))).............))))..))).((.(.(...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..(..((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))....)...)..)..(((((((((..)))))))))}..... Cryo-EM structure of Escherichia coli transcription-translation complex A (TTC-A) containing mRNA with a 12 nt long spacer; 16S rRNA 6vu3 a 2880 3.7 RF02540,RF02541 URS0000B21DEA_562 32820061 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaacccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcggggcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacgguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccucccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccgaacaaacgguccuaagguagcgaaauccuugucggguaaguuccgacugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugagaugcaguguacccgcggcaagacggaaagaccccguaaccuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgggauaacaggcgauaccgcccaagaguucauaucgacggcgguguuuggcacucggucggcucaucacauccuggggcugaaguaggucccaaggguauggcguucgccauuuaaagugguacgcgagcggguuuagaacgucgugagacagucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<.<....<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>..>>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>>.>>...............<<....>>....>>.........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<.....>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>>.>>...>>>>>>>.>...<<<<<<<<<.......>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....[[[...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<.....>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>.>......>>>>>>>>..>>>>..<<<<......>>>>.........<..........<<<<<<.....>>>>>>....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<.......>>>>>..<<<<<<<<.<<<.<<......<.<<..<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<..<<.......<<<<<<<<....>>>>>>>>....>>............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>..............>>>....>>>........<<...<<<<<<...<<.......>>...>>>>>>.....>>......<<.<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<....>>>>>.....>>>>>..>...>>.>>....<.<<<<<....>>>.>>>....>>..>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]].>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((.(.....)).)))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((..(.........)...))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((.......)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(.((..(((..((((.......))))..))).....(..(((......))))..)).)...)))..))))).))...........]]].)...))))))))))...)))))))(((((..((....))..)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((.(((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....)))).)))))).))).))).....((.....)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.((..(((((((..(((........(((((..((....))...)))))........))))))))..))))....((......))...........((.........(((((.......))))).)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((....]}.)))))..((((((((.(((.((......(.((.((((..(((((.(((.(((((.(((((((((((.(.((.(..........(((...(((.......(((((((....)))))))....))).............))).).)).).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((.....[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}.......)))..).)))......(.((.(.((((((...((.......))...))))))...).))..)....(.((.((((((..(((((((((......))))))..))).(((((....))))).....)))))..)...)).).....(.(((((....))).)))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((.(....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Cryo-EM structure of Escherichia coli transcription-translation complex A (TTC-A) containing mRNA with a 12 nt long spacer; 23S rRNA 6vu3 d 120 3.7 RF00001 URS0000049E57_562 32820061 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. .(((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))).. Cryo-EM structure of Escherichia coli transcription-translation complex A (TTC-A) containing mRNA with a 12 nt long spacer; 5S rRNA 6vwl 3 120 3.1 RF00001 URS00008116C5_562 32427100 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<......<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>....>>>>>>>>>. ((((((((((.....((.(((((....(((((((...(.....)...))))..)))...)))))..)).((.......((((((((...)))))))).......))...)))))))))). 70S ribosome bound to HIV frameshifting stem-loop (FSS) and P/E tRNA (rotated conformation); 5S ribosomal RNA 6vwl 5 76 3.1 RF00005 URS0001A24B56_562 32427100 0030533 0006412 562 gcccggauagcucagucgguagagcaggggauugaaaauccccguggucuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((........)))).(((((.......))))).....((.((.......)).))))))))).... 70S ribosome bound to HIV frameshifting stem-loop (FSS) and P/E tRNA (rotated conformation); tRNAPhe 6vwl 2 2833 3.1 RF02540,RF02541 URS0000BC4674_562 32427100 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugucgaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<.<<<<<<..<..>..>>>>>>>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<....<<....>>.....>>>..>.....>>>>>>>>..>>>>>.<<<<<.......>>>>>.........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<...<<......<<<<<<<......>>>>>>>...>>.............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>.(<<...<<<<<<<...<<<<<<.......>>>>>>.....<<)..(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....(((((((..(((]]]..].)))......)))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((.((((((.((.(((...(((((......)))))[[......(((.....]])))...)))...)).)))))).)))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((....(((((......)))))....)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))..(((((((..((((((((((.....(((...(((.((((...((..(((.....)))...))...)))).)))..)).).....)))))).)))..)))))))).....((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(..)..))))).))...........]]].)...))))))))))...)))))))((((.((((....)))).))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((...(((...(((....)))...)))...)))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...(((.((((((((.((.....))))))))))...)))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((....((((..)])))....)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........((((...((....))....))))........))))))))..)))))(.(((.........))).)........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((.(.(..[.......((((....(.......((.(((......))).))....)........].....)))).).).)).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). 70S ribosome bound to HIV frameshifting stem-loop (FSS) and P/E tRNA (rotated conformation); 23S ribosomal RNA 6vwl 1 1521 3.1 RF00177,RF01959,RF01960 URS0001A24B58_562 32427100 0003735 0005840 562 ugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagcuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugccgcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguagggaaaccugcgguuggaucaccuccuu ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<..>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<.......<<<....>>>......>>>>..<<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>>.<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<.>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<..<<<<<.<<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>....<....>...>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.>...<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>.....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............. ....((((...[[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((.((()))..)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....(((.(...((....)).).))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..(.((......(.((....)).).....)).)..((.(((((...(..(.((((((((.......)))))))).)...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.((((((..((((((((((......((((((.....))))))....))))))))..)).))))))..(((((((((...((((((((....(((((.(...((........))......).)))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((((.)))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((.(..((((((((((......((........))..........(((((((..(...(((((((...((.(((....))).))....((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....))))))).....(((((.....)))))........)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(.(((((.....(((..((...(((....)))...))....))).....))))).)......(....(((((((........)))))))....)..)..).))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}............ 70S ribosome bound to HIV frameshifting stem-loop (FSS) and P/E tRNA (rotated conformation); 16S ribosomal RNA 6vwl 4 43 3.1 RF00480 URS0002335978_11676 32427100 0075523 11676 auguucgagaagaucuggccuucccacaagggaaggccaggga .............<<<<<<<<<<<<....>>>>>>>>>>>>.. .............((((((((((((....)))))))))))).. 70S ribosome bound to HIV frameshifting stem-loop (FSS) and P/E tRNA (rotated conformation); HIV frameshift stimulating sequence mRNA 6vwm 3 120 3.4 RF00001 URS00008116C5_562 32427100 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<......<<<<<<<<....<<.<<<...............>>>...>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>....>>>>>>>>>. ((((((((((.....((.(((((....(...(((...(.....)...))).....)...)))))..)).((.......((((((((...)))))))).......))...)))))))))). 70S ribosome bound to HIV frameshifting stem-loop (FSS) and P-site tRNA (non-rotated conformation, Structure I); 5S ribosomal RNA 6vwm 5 76 3.4 RF00005 URS0001A24B56_562 32427100 0030533 0006412 562 gcccggauagcucagucgguagagcaggggauugaaaauccccguggucuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... ...((((..((((.....[..)))).(((((.......))))).....((.((..]....)).))))))....... 70S ribosome bound to HIV frameshifting stem-loop (FSS) and P-site tRNA (non-rotated conformation, Structure I); tRNAPhe 6vwm 2 2833 3.4 RF02540,RF02541 URS0000BC4674_562 32427100 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugucgaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((....<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>..........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>...>.>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<<.....>>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<.<<<<<<..<..>..>>>>>>>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><<<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>.>>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>>...<<<<<....>>>>>....>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<<..<<<<<<.<<....>>.>.>>>>>>>......>>>>>>>>..>>>>>.<<<<<.......>>>>>.........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<..<<<<.............<<<..<<<.......<<<<<<......>>>>>>....>>>............>>>....>>>>..>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((.((((((.((.(((...(((((......)))))[[......(((.....]])))...)))...)).)))))).)))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((.(......).))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.(((....(((((((.....))))).))....))).)))..)).).....)))))).)))..)))))))).)...((((.(((((......))))).))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((.((..(())..)).)).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(((((((...(((......((.(((((....))))).))...)))..))))).)).....))))))(......((.....(((((......[..)))))((((....((((..((..(((((((...((.]...)).))))))....[[(((.(((...(((...(((....)))...)))...)))..(((((........)))))]](((.(((((((((...((((....((((..(((..(((((.((((((...{{{.).))))).((..((((...(((((.((((((.((.....)))))))).)..))))..[))))...))(...((((....))))....))))))...)))...))))(..).....))))...))....))))))).))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((..(..(....(.......(((((....(.{..).....)))))((((((.....(((....((((..)])))....)))...))))))(...).......(((((.(((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((...((........((((((.((....))..))))))........)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).).))))).)..))..)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((((..(((.((((.............(((....(........(..((......))..).....)..............)))....)))).)).).))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). 70S ribosome bound to HIV frameshifting stem-loop (FSS) and P-site tRNA (non-rotated conformation, Structure I); 23S ribosomal RNA 6vwm 1 1508 3.4 RF00177,RF01959,RF01960 URS0001A24B58_562 32427100 0003735 0005840 562 agaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagcuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcgcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguagggaaaccugcgguuggau .<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<..>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<<....>>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>..<<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>>.<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<..>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.... .((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((.((()))..)))))..)))))......(((......(((((((..((...(((((((.(.((......(((((....))))).......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..(((.......((((....))))......)))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((....((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..)))....))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((()))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].]((((..(((((((.....(((((..((((.(((((......((........))..........(((((((..(...(((((((..(((.(((....))).)))....(....)...))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(.(......))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).))).)))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))...........))))))).)).))..(.(..((...((((.(((..(((((((.((((....((((((.(((...((....))..)))))))))...)))).)))))))..))).))))....))...)..)..(((((((((....)))))))))}... 70S ribosome bound to HIV frameshifting stem-loop (FSS) and P-site tRNA (non-rotated conformation, Structure I); 16S ribosomal RNA 6vwm 4 43 3.4 RF00480 URS0002335978_11676 32427100 0075523 11676 auguucgagaagaucuggccuucccacaagggaaggccaggga .............<<<<<<<<<<<<....>>>>>>>>>>>>.. .............((((((((((((....)))))))))))).. 70S ribosome bound to HIV frameshifting stem-loop (FSS) and P-site tRNA (non-rotated conformation, Structure I); HIV frameshift stimulating sequence mRNA 6vwn 3 120 3.4 RF00001 URS00008116C5_562 32427100 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<......<<<<<<<<....<<.<<<...............>>>...>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>....>>>>>>>>>. ((((((((((.....((.(((((....(...(((...(.....)...))).....)...)))))..)).((.......((((((((...)))))))).......))...)))))))))). 70S ribosome bound to HIV frameshifting stem-loop (FSS) and P-site tRNA (non-rotated conformation, Structure II); 5S ribosomal RNA 6vwn 5 76 3.4 RF00005 URS00005AA258_562 32427100 0030533 0006412 562 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... ...((((..((((.....[..)))).(((((.......))))).....((.((..]....)).))))))....... 70S ribosome bound to HIV frameshifting stem-loop (FSS) and P-site tRNA (non-rotated conformation, Structure II); tRNAPhe 6vwn 2 2833 3.4 RF02540,RF02541 URS0000BC4674_562 32427100 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugucgaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((...<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>.........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>...>.>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<<.....>>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<.<<<<<<..<..>..>>>>>>>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><<<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>.>>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<<..<<<<<<.<<....>>.>.>>>>>>>......>>>>>>>>..>>>>>.<<<<<.......>>>>>.........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<..<<<<.............<<<..<<<.......<<<<<<......>>>>>>....>>>............>>>....>>>>..>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((.((((((.((.(((...(((((......)))))[[......(((.....]])))...)))...)).)))))).)))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((.(......).))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.(((....(((((((.....))))).))....))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((.((..(())..)).)).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(((((((...(((......((.(((((....))))).))...)))..))))).)).....))))))(......((.....(((((......[..)))))((((....((((..((..(((((((...((.]...)).))))))....[[(((.(((...(((...(((....)))...)))...)))..(((((........)))))]](((((((((((((...((((....((((..(((..(((((.((((((...{{{.).))))).((..((((...(((((.((((((.((.....)))))))).)..))))..[))))...))(...((((....))))....))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((..(..(....(.......(((((....(.{..).....)))))((((((.....(((....((((..)])))....)))...))))))(...).......(((((.(((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((...((........((((((.((....))..))))))........)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).).))))).)..))..)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((((..(((.((((.(...........(((....(.......((..((......))..))....)..............)))..).)))).)))..))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). 70S ribosome bound to HIV frameshifting stem-loop (FSS) and P-site tRNA (non-rotated conformation, Structure II); 23S ribosomal RNA 6vwn 1 1508 3.4 RF00177,RF01959,RF01960 URS0001A24B58_562 32427100 0003735 0005840 562 agaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagcuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcgcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguagggaaaccugcgguuggau .<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<..>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<<....>>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>..<<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>>.<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<..>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.... .((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((.((()))..)))))..)))))......(((......(((((((..((...(((((((.(.((......(((((....))))).......)).).....(((....))).....(((((..((....)))))))..)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..(((.......((((....))))......)))..((.(((((...(...(((((((((.......)))))))).)...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((....((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..)))....))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((()))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].]((((..(((((((.....(((((..((((((((((......((........))..........(((((((..(...(((((((..(((.(((....))).)))....(....)...))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(.(((((.....(((..((...(((....)))...))....))).....))))).)......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))...........))))))).)).))..(.(..((...((((.(((..(((((((.((((....((((((.(((...((....))..)))))))))...)))).)))))))..))).))))....))...)..)..(((((((((....)))))))))}... 70S ribosome bound to HIV frameshifting stem-loop (FSS) and P-site tRNA (non-rotated conformation, Structure II); 16S ribosomal RNA 6vwn 4 43 3.4 RF00480 URS0002335978_11676 32427100 0075523 11676 auguucgagaagaucuggccuucccacaagggaaggccaggga .............<<<<<<<<<<<<....>>>>>>>>>>>>.. .............((((((((((((....)))))))))))).. 70S ribosome bound to HIV frameshifting stem-loop (FSS) and P-site tRNA (non-rotated conformation, Structure II); HIV1 frameshift stimulating sequence mRNA 6vyq 7 32 3.7 32820061 32630 auguuuuuuuuuuuuuuugauuuggugagagg ................................ ................................ Escherichia coli transcription-translation complex A1 (TTC-A1) containing an 15 nt long mRNA spacer, NusG, and fMet-tRNAs at E-site and P-site; mRNA with 15 nt long spacer 6vyq A 76 3.7 RF00005 URS000080DFF5_562 32820061 0030533 0006412 562 cgcgggguggagcagccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((........)))).(((((.......))))).....(((((.......)))))))))))..... Escherichia coli transcription-translation complex A1 (TTC-A1) containing an 15 nt long mRNA spacer, NusG, and fMet-tRNAs at E-site and P-site; E-site and P-site tRNA (fMet) 6vyq B 76 3.7 RF00005 URS000080DFF5_562 32820061 0030533 0006412 562 cgcgggguggagcagccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<........>>>>.<<<<.........>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((........)))).(((...........))).....(((((.......)))))))))))..... Escherichia coli transcription-translation complex A1 (TTC-A1) containing an 15 nt long mRNA spacer, NusG, and fMet-tRNAs at E-site and P-site; E-site and P-site tRNA (fMet) 6vyq D 1524 3.7 RF00177,RF01959,RF01960 URS00000ABFE9_562 32820061 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccggccagcagcccgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgauaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgccguacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgaacaagguaaccguaggggccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<......>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>..<<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>>.<<<<<(((...<<<<<.......)))........>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<......>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<......<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>..>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>......<<..<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>....>>........<<<<<<<<<..>>>>>>>>>...... ........((((..[.[[[[.)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((........))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..........)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((((.......)))))))).....)....)))))....)..((((([[[...(((((....(..]]]).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))..]]]].](((((.(((((((.((..(((((..((((((((((......((......))..........(((((((..(...((.((((..(((.(((....))).))).............))))..))).((.(.(...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..(..((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))....)...)..)..(((((((((..)))))))))}..... Escherichia coli transcription-translation complex A1 (TTC-A1) containing an 15 nt long mRNA spacer, NusG, and fMet-tRNAs at E-site and P-site; 16S rRNA 6vyq a 2880 3.7 RF02540,RF02541 URS0000B21DEA_562 32820061 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaacccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcggggcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacgguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccucccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccgaacaaacgguccuaagguagcgaaauccuugucggguaaguuccgacugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugagaugcaguguacccgcggcaagacggaaagaccccguaaccuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgggauaacaggcgauaccgcccaagaguucauaucgacggcgguguuuggcacucggucggcucaucacauccuggggcugaaguaggucccaaggguauggcguucgccauuuaaagugguacgcgagcggguuuagaacgucgugagacagucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<.<....<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>..>>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>>.>>...............<<....>>....>>.........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<.....>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>>.>>...>>>>>>>.>...<<<<<<<<<.......>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....[[[...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<.....>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>.>......>>>>>>>>..>>>>..<<<<......>>>>.........<..........<<<<<<.....>>>>>>....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<.......>>>>>..<<<<<<<<.<<<.<<......<.<<..<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<..<<.......<<<<<<<<....>>>>>>>>....>>............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>..............>>>....>>>........<<...<<<<<<...<<.......>>...>>>>>>.....>>......<<.<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<....>>>>>.....>>>>>..>...>>.>>....<.<<<<<....>>>.>>>....>>..>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]].>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((.(.....)).)))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((..(.........)...))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((.......)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(.((..(((..((((.......))))..))).....(..(((......))))..)).)...)))..))))).))...........]]].)...))))))))))...)))))))(((((..((....))..)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((.(((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....)))).)))))).))).))).....((.....)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.((..(((((((..(((........(((((..((....))...)))))........))))))))..))))....((......))...........((.........(((((.......))))).)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((....]}.)))))..((((((((.(((.((......(.((.((((..(((((.(((.(((((.(((((((((((.(.((.(..........(((...(((.......(((((((....)))))))....))).............))).).)).).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((.....[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}.......)))..).)))......(.((.(.((((((...((.......))...))))))...).))..)....(.((.((((((..(((((((((......))))))..))).(((((....))))).....)))))..)...)).).....(.(((((....))).)))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((.(....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Escherichia coli transcription-translation complex A1 (TTC-A1) containing an 15 nt long mRNA spacer, NusG, and fMet-tRNAs at E-site and P-site; 23S rRNA 6vyq d 120 3.7 RF00001 URS0000049E57_562 32820061 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. .(((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))).. Escherichia coli transcription-translation complex A1 (TTC-A1) containing an 15 nt long mRNA spacer, NusG, and fMet-tRNAs at E-site and P-site; 5S rRNA 6vyr 7 35 3.8 32820061 32630 auguuuuuuuuuuuuuuuuuugauuuggugagagg ................................... ................................... Escherichia coli transcription-translation complex A1 (TTC-A1) containing an 18 nt long mRNA spacer, NusG, and fMet-tRNAs at E-site and P-site; mRNA with 18 nt long spacer 6vyr A 76 3.8 RF00005 URS000080DFF5_562 32820061 0030533 0006412 562 cgcgggguggagcagccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((........)))).(((((.......))))).....(((((.......)))))))))))..... Escherichia coli transcription-translation complex A1 (TTC-A1) containing an 18 nt long mRNA spacer, NusG, and fMet-tRNAs at E-site and P-site; E-site and P-site tRNA (fMet) 6vyr B 76 3.8 RF00005 URS000080DFF5_562 32820061 0030533 0006412 562 cgcgggguggagcagccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<........>>>>.<<<<.........>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((........)))).(((...........))).....(((((.......)))))))))))..... Escherichia coli transcription-translation complex A1 (TTC-A1) containing an 18 nt long mRNA spacer, NusG, and fMet-tRNAs at E-site and P-site; E-site and P-site tRNA (fMet) 6vyr D 1524 3.8 RF00177,RF01959,RF01960 URS00000ABFE9_562 32820061 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccggccagcagcccgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgauaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgccguacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgaacaagguaaccguaggggccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<......>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>..<<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>>.<<<<<(((...<<<<<.......)))........>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<......>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<......<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>..>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>......<<..<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>....>>........<<<<<<<<<..>>>>>>>>>...... ........((((..[.[[[[.)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((........))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..........)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((((.......)))))))).....)....)))))....)..((((([[[...(((((....(..]]]).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))..]]]].](((((.(((((((.((..(((((..((((((((((......((......))..........(((((((..(...((.((((..(((.(((....))).))).............))))..))).((.(.(...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..(..((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))....)...)..)..(((((((((..)))))))))}..... Escherichia coli transcription-translation complex A1 (TTC-A1) containing an 18 nt long mRNA spacer, NusG, and fMet-tRNAs at E-site and P-site; 16S rRNA 6vyr a 2880 3.8 RF02540,RF02541 URS0000B21DEA_562 32820061 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaacccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcggggcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacgguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccucccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccgaacaaacgguccuaagguagcgaaauccuugucggguaaguuccgacugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugagaugcaguguacccgcggcaagacggaaagaccccguaaccuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgggauaacaggcgauaccgcccaagaguucauaucgacggcgguguuuggcacucggucggcucaucacauccuggggcugaaguaggucccaaggguauggcguucgccauuuaaagugguacgcgagcggguuuagaacgucgugagacagucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<.<....<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>..>>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>>.>>...............<<....>>....>>.........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<.....>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>>.>>...>>>>>>>.>...<<<<<<<<<.......>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....[[[...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<.....>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>.>......>>>>>>>>..>>>>..<<<<......>>>>.........<..........<<<<<<.....>>>>>>....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<.......>>>>>..<<<<<<<<.<<<.<<......<.<<..<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<..<<.......<<<<<<<<....>>>>>>>>....>>............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>..............>>>....>>>........<<...<<<<<<...<<.......>>...>>>>>>.....>>......<<.<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<....>>>>>.....>>>>>..>...>>.>>....<.<<<<<....>>>.>>>....>>..>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]].>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((.(.....)).)))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((..(.........)...))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((.......)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(.((..(((..((((.......))))..))).....(..(((......))))..)).)...)))..))))).))...........]]].)...))))))))))...)))))))(((((..((....))..)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((.(((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....)))).)))))).))).))).....((.....)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.((..(((((((..(((........(((((..((....))...)))))........))))))))..))))....((......))...........((.........(((((.......))))).)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((....]}.)))))..((((((((.(((.((......(.((.((((..(((((.(((.(((((.(((((((((((.(.((.(..........(((...(((.......(((((((....)))))))....))).............))).).)).).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((.....[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}.......)))..).)))......(.((.(.((((((...((.......))...))))))...).))..)....(.((.((((((..(((((((((......))))))..))).(((((....))))).....)))))..)...)).).....(.(((((....))).)))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((.(....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Escherichia coli transcription-translation complex A1 (TTC-A1) containing an 18 nt long mRNA spacer, NusG, and fMet-tRNAs at E-site and P-site; 23S rRNA 6vyr d 120 3.8 RF00001 URS0000049E57_562 32820061 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. .(((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))).. Escherichia coli transcription-translation complex A1 (TTC-A1) containing an 18 nt long mRNA spacer, NusG, and fMet-tRNAs at E-site and P-site; 5S rRNA 6vys 7 26 3.7 32820061 32630 auguuuuuuuuuuuuuuggugagagg .......................... .......................... Escherichia coli transcription-translation complex A1 (TTC-A1) containing a 21 nt long mRNA spacer, NusG, and fMet-tRNAs at E-site and P-site; mRNA with 21 nt long spacer 6vys A 76 3.7 RF00005 URS000080DFF5_562 32820061 0030533 0006412 562 cgcgggguggagcagccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((........)))).(((((.......))))).....(((((.......)))))))))))..... Escherichia coli transcription-translation complex A1 (TTC-A1) containing a 21 nt long mRNA spacer, NusG, and fMet-tRNAs at E-site and P-site; E-site and P-site tRNA (fMet) 6vys B 76 3.7 RF00005 URS000080DFF5_562 32820061 0030533 0006412 562 cgcgggguggagcagccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<........>>>>.<<<<.........>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((........)))).(((...........))).....(((((.......)))))))))))..... Escherichia coli transcription-translation complex A1 (TTC-A1) containing a 21 nt long mRNA spacer, NusG, and fMet-tRNAs at E-site and P-site; E-site and P-site tRNA (fMet) 6vys D 1524 3.7 RF00177,RF01959,RF01960 URS00000ABFE9_562 32820061 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccggccagcagcccgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgauaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgccguacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgaacaagguaaccguaggggccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<......>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>..<<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>>.<<<<<(((...<<<<<.......)))........>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<......>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<......<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>..>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>......<<..<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>....>>........<<<<<<<<<..>>>>>>>>>...... ........((((..[.[[[[.)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((........))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..........)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((((.......)))))))).....)....)))))....)..((((([[[...(((((....(..]]]).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))..]]]].](((((.(((((((.((..(((((..((((((((((......((......))..........(((((((..(...((.((((..(((.(((....))).))).............))))..))).((.(.(...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..(..((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))....)...)..)..(((((((((..)))))))))}..... Escherichia coli transcription-translation complex A1 (TTC-A1) containing a 21 nt long mRNA spacer, NusG, and fMet-tRNAs at E-site and P-site; 16S rRNA 6vys a 2880 3.7 RF02540,RF02541 URS0000B21DEA_562 32820061 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaacccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcggggcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacgguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccucccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccgaacaaacgguccuaagguagcgaaauccuugucggguaaguuccgacugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugagaugcaguguacccgcggcaagacggaaagaccccguaaccuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgggauaacaggcgauaccgcccaagaguucauaucgacggcgguguuuggcacucggucggcucaucacauccuggggcugaaguaggucccaaggguauggcguucgccauuuaaagugguacgcgagcggguuuagaacgucgugagacagucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<.<....<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>..>>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>>.>>...............<<....>>....>>.........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<.....>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>>.>>...>>>>>>>.>...<<<<<<<<<.......>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....[[[...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<.....>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>.>......>>>>>>>>..>>>>..<<<<......>>>>.........<..........<<<<<<.....>>>>>>....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<.......>>>>>..<<<<<<<<.<<<.<<......<.<<..<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<..<<.......<<<<<<<<....>>>>>>>>....>>............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>..............>>>....>>>........<<...<<<<<<...<<.......>>...>>>>>>.....>>......<<.<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<....>>>>>.....>>>>>..>...>>.>>....<.<<<<<....>>>.>>>....>>..>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]].>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((.(.....)).)))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((..(.........)...))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((.......)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(.((..(((..((((.......))))..))).....(..(((......))))..)).)...)))..))))).))...........]]].)...))))))))))...)))))))(((((..((....))..)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((.(((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....)))).)))))).))).))).....((.....)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.((..(((((((..(((........(((((..((....))...)))))........))))))))..))))....((......))...........((.........(((((.......))))).)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((....]}.)))))..((((((((.(((.((......(.((.((((..(((((.(((.(((((.(((((((((((.(.((.(..........(((...(((.......(((((((....)))))))....))).............))).).)).).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((.....[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}.......)))..).)))......(.((.(.((((((...((.......))...))))))...).))..)....(.((.((((((..(((((((((......))))))..))).(((((....))))).....)))))..)...)).).....(.(((((....))).)))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((.(....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Escherichia coli transcription-translation complex A1 (TTC-A1) containing a 21 nt long mRNA spacer, NusG, and fMet-tRNAs at E-site and P-site; 23S rRNA 6vys d 120 3.7 RF00001 URS0000049E57_562 32820061 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. .(((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))).. Escherichia coli transcription-translation complex A1 (TTC-A1) containing a 21 nt long mRNA spacer, NusG, and fMet-tRNAs at E-site and P-site; 5S rRNA 6vyt A 76 14.0 RF00005 URS000080DFF5_562 32820061 0030533 0006412 562 cgcgggguggagcagccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((........)))).(((((.......))))).....(((((.......)))))))))))..... Escherichia coli transcription-translation complex A2 (TTC-A2) containing a 15 nt long mRNA spacer, NusG, and fMet-tRNAs at P-site and E-site; E-site and P-site tRNA (fMet) 6vyt B 76 14.0 RF00005 URS000080DFF5_562 32820061 0030533 0006412 562 cgcgggguggagcagccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<........>>>>.<<<<.........>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((........)))).(((...........))).....(((((.......)))))))))))..... Escherichia coli transcription-translation complex A2 (TTC-A2) containing a 15 nt long mRNA spacer, NusG, and fMet-tRNAs at P-site and E-site; E-site and P-site tRNA (fMet) 6vyt D 1524 14.0 RF00177,RF01959,RF01960 URS00000ABFE9_562 32820061 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccggccagcagcccgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgauaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgccguacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgaacaagguaaccguaggggccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<......>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>..<<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>>.<<<<<(((...<<<<<.......)))........>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<......>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<......<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>..>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>......<<..<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>....>>........<<<<<<<<<..>>>>>>>>>...... ........((((..[.[[[[.)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((........))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..........)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((((.......)))))))).....)....)))))....)..((((([[[...(((((....(..]]]).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))..]]]].](((((.(((((((.((..(((((..((((((((((......((......))..........(((((((..(...((.((((..(((.(((....))).))).............))))..))).((.(.(...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..(..((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))....)...)..)..(((((((((..)))))))))}..... Escherichia coli transcription-translation complex A2 (TTC-A2) containing a 15 nt long mRNA spacer, NusG, and fMet-tRNAs at P-site and E-site; 16S rRNA 6vyt a 2880 14.0 RF02540,RF02541 URS0000B21DEA_562 32820061 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaacccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcggggcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacgguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccucccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccgaacaaacgguccuaagguagcgaaauccuugucggguaaguuccgacugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugagaugcaguguacccgcggcaagacggaaagaccccguaaccuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgggauaacaggcgauaccgcccaagaguucauaucgacggcgguguuuggcacucggucggcucaucacauccuggggcugaaguaggucccaaggguauggcguucgccauuuaaagugguacgcgagcggguuuagaacgucgugagacagucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<.<....<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>..>>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>>.>>...............<<....>>....>>.........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<.....>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>>.>>...>>>>>>>.>...<<<<<<<<<.......>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....[[[...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<.....>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>.>......>>>>>>>>..>>>>..<<<<......>>>>.........<..........<<<<<<.....>>>>>>....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<.......>>>>>..<<<<<<<<.<<<.<<......<.<<..<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<..<<.......<<<<<<<<....>>>>>>>>....>>............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>..............>>>....>>>........<<...<<<<<<...<<.......>>...>>>>>>.....>>......<<.<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<....>>>>>.....>>>>>..>...>>.>>....<.<<<<<....>>>.>>>....>>..>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]].>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((.(.....)).)))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((..(.........)...))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((.......)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(.((..(((..((((.......))))..))).....(..(((......))))..)).)...)))..))))).))...........]]].)...))))))))))...)))))))(((((..((....))..)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((.(((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....)))).)))))).))).))).....((.....)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.((..(((((((..(((........(((((..((....))...)))))........))))))))..))))....((......))...........((.........(((((.......))))).)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((....]}.)))))..((((((((.(((.((......(.((.((((..(((((.(((.(((((.(((((((((((.(.((.(..........(((...(((.......(((((((....)))))))....))).............))).).)).).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((.....[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}.......)))..).)))......(.((.(.((((((...((.......))...))))))...).))..)....(.((.((((((..(((((((((......))))))..))).(((((....))))).....)))))..)...)).).....(.(((((....))).)))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((.(....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Escherichia coli transcription-translation complex A2 (TTC-A2) containing a 15 nt long mRNA spacer, NusG, and fMet-tRNAs at P-site and E-site; 23S rRNA 6vyt d 120 14.0 RF00001 URS0000049E57_562 32820061 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. .(((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))).. Escherichia coli transcription-translation complex A2 (TTC-A2) containing a 15 nt long mRNA spacer, NusG, and fMet-tRNAs at P-site and E-site; 5S rRNA 6vyu A 76 7.0 RF00005 URS000080DFF5_562 32820061 0030533 0006412 562 cgcgggguggagcagccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((........)))).(((((.......))))).....(((((.......)))))))))))..... Escherichia coli transcription-translation complex C2 (TTC-C2) containing a 27 nt long mRNA spacer; E-site fMet-tRNA 6vyu B 76 7.0 RF00005 URS000080DFF5_562 32820061 0030533 0006412 562 cgcgggguggagcagccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<........>>>>.<<<<.........>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((........)))).(((...........))).....(((((.......)))))))))))..... Escherichia coli transcription-translation complex C2 (TTC-C2) containing a 27 nt long mRNA spacer; E-site fMet-tRNA 6vyu D 1524 7.0 RF00177,RF01959,RF01960 URS00000ABFE9_562 32820061 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccggccagcagcccgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgauaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgccguacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgaacaagguaaccguaggggccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<......>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>..<<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>>.<<<<<(((...<<<<<.......)))........>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<......>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<......<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>..>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>......<<..<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>....>>........<<<<<<<<<..>>>>>>>>>...... ........((((..[.[[[[.)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((........))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..........)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((((.......)))))))).....)....)))))....)..((((([[[...(((((....(..]]]).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))..]]]].](((((.(((((((.((..(((((..((((((((((......((......))..........(((((((..(...((.((((..(((.(((....))).))).............))))..))).((.(.(...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..(..((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))....)...)..)..(((((((((..)))))))))}..... Escherichia coli transcription-translation complex C2 (TTC-C2) containing a 27 nt long mRNA spacer; 16S rRNA 6vyu a 2880 7.0 RF02540,RF02541 URS0000B21DEA_562 32820061 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaacccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcggggcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacgguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccucccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccgaacaaacgguccuaagguagcgaaauccuugucggguaaguuccgacugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugagaugcaguguacccgcggcaagacggaaagaccccguaaccuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgggauaacaggcgauaccgcccaagaguucauaucgacggcgguguuuggcacucggucggcucaucacauccuggggcugaaguaggucccaaggguauggcguucgccauuuaaagugguacgcgagcggguuuagaacgucgugagacagucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<.<....<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>..>>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>>.>>...............<<....>>....>>.........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<.....>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>>.>>...>>>>>>>.>...<<<<<<<<<.......>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....[[[...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<.....>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>.>......>>>>>>>>..>>>>..<<<<......>>>>.........<..........<<<<<<.....>>>>>>....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<.......>>>>>..<<<<<<<<.<<<.<<......<.<<..<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<..<<.......<<<<<<<<....>>>>>>>>....>>............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>..............>>>....>>>........<<...<<<<<<...<<.......>>...>>>>>>.....>>......<<.<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<....>>>>>.....>>>>>..>...>>.>>....<.<<<<<....>>>.>>>....>>..>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]].>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((.(.....)).)))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((..(.........)...))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((.......)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(.((..(((..((((.......))))..))).....(..(((......))))..)).)...)))..))))).))...........]]].)...))))))))))...)))))))(((((..((....))..)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((.(((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....)))).)))))).))).))).....((.....)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.((..(((((((..(((........(((((..((....))...)))))........))))))))..))))....((......))...........((.........(((((.......))))).)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((....]}.)))))..((((((((.(((.((......(.((.((((..(((((.(((.(((((.(((((((((((.(.((.(..........(((...(((.......(((((((....)))))))....))).............))).).)).).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((.....[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}.......)))..).)))......(.((.(.((((((...((.......))...))))))...).))..)....(.((.((((((..(((((((((......))))))..))).(((((....))))).....)))))..)...)).).....(.(((((....))).)))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((.(....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Escherichia coli transcription-translation complex C2 (TTC-C2) containing a 27 nt long mRNA spacer; 23S rRNA 6vyu d 120 7.0 RF00001 URS0000049E57_562 32820061 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. .(((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))).. Escherichia coli transcription-translation complex C2 (TTC-C2) containing a 27 nt long mRNA spacer; 5S rRNA 6vyw A 76 7.0 RF00005 URS000080DFF5_562 32820061 0030533 0006412 562 cgcgggguggagcagccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((........)))).(((((.......))))).....(((((.......)))))))))))..... Escherichia coli transcription-translation complex C3 (TTC-C3) containing mRNA with a 27 nt long spacer, NusG, and fMet-tRNAs at E-site and P-site; E-site and P-site tRNA (fMet) 6vyw B 76 7.0 RF00005 URS000080DFF5_562 32820061 0030533 0006412 562 cgcgggguggagcagccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<........>>>>.<<<<.........>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((........)))).(((...........))).....(((((.......)))))))))))..... Escherichia coli transcription-translation complex C3 (TTC-C3) containing mRNA with a 27 nt long spacer, NusG, and fMet-tRNAs at E-site and P-site; E-site and P-site tRNA (fMet) 6vyw D 1524 7.0 RF00177,RF01959,RF01960 URS00000ABFE9_562 32820061 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccggccagcagcccgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgauaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgccguacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgaacaagguaaccguaggggccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<......>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>..<<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>>.<<<<<(((...<<<<<.......)))........>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<......>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<......<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>..>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>......<<..<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>....>>........<<<<<<<<<..>>>>>>>>>...... ........((((..[.[[[[.)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((........))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..........)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((((.......)))))))).....)....)))))....)..((((([[[...(((((....(..]]]).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))..]]]].](((((.(((((((.((..(((((..((((((((((......((......))..........(((((((..(...((.((((..(((.(((....))).))).............))))..))).((.(.(...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..(..((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))....)...)..)..(((((((((..)))))))))}..... Escherichia coli transcription-translation complex C3 (TTC-C3) containing mRNA with a 27 nt long spacer, NusG, and fMet-tRNAs at E-site and P-site; 16S rRNA 6vyw a 2880 7.0 RF02540,RF02541 URS0000B21DEA_562 32820061 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaacccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcggggcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacgguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccucccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccgaacaaacgguccuaagguagcgaaauccuugucggguaaguuccgacugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugagaugcaguguacccgcggcaagacggaaagaccccguaaccuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgggauaacaggcgauaccgcccaagaguucauaucgacggcgguguuuggcacucggucggcucaucacauccuggggcugaaguaggucccaaggguauggcguucgccauuuaaagugguacgcgagcggguuuagaacgucgugagacagucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<.<....<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>..>>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>>.>>...............<<....>>....>>.........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<.....>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>>.>>...>>>>>>>.>...<<<<<<<<<.......>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....[[[...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<.....>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>.>......>>>>>>>>..>>>>..<<<<......>>>>.........<..........<<<<<<.....>>>>>>....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<.......>>>>>..<<<<<<<<.<<<.<<......<.<<..<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<..<<.......<<<<<<<<....>>>>>>>>....>>............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>..............>>>....>>>........<<...<<<<<<...<<.......>>...>>>>>>.....>>......<<.<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<....>>>>>.....>>>>>..>...>>.>>....<.<<<<<....>>>.>>>....>>..>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]].>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((.(.....)).)))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((..(.........)...))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((.......)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(.((..(((..((((.......))))..))).....(..(((......))))..)).)...)))..))))).))...........]]].)...))))))))))...)))))))(((((..((....))..)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((.(((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....)))).)))))).))).))).....((.....)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.((..(((((((..(((........(((((..((....))...)))))........))))))))..))))....((......))...........((.........(((((.......))))).)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((....]}.)))))..((((((((.(((.((......(.((.((((..(((((.(((.(((((.(((((((((((.(.((.(..........(((...(((.......(((((((....)))))))....))).............))).).)).).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((.....[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}.......)))..).)))......(.((.(.((((((...((.......))...))))))...).))..)....(.((.((((((..(((((((((......))))))..))).(((((....))))).....)))))..)...)).).....(.(((((....))).)))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((.(....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Escherichia coli transcription-translation complex C3 (TTC-C3) containing mRNA with a 27 nt long spacer, NusG, and fMet-tRNAs at E-site and P-site; 23S rRNA 6vyw d 120 7.0 RF00001 URS0000049E57_562 32820061 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. .(((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))).. Escherichia coli transcription-translation complex C3 (TTC-C3) containing mRNA with a 27 nt long spacer, NusG, and fMet-tRNAs at E-site and P-site; 5S rRNA 6vyx A 76 9.9 RF00005 URS000080DFF5_562 32820061 0030533 0006412 562 cgcgggguggagcagccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((........)))).(((((.......))))).....(((((.......)))))))))))..... Escherichia coli transcription-translation complex C4 (TTC-C4) containing mRNA with a 21 nt long spacer, transcription factor NusG, and fMet-tRNAs at P-site and E-site; E-site and P-site tRNA (fMet) 6vyx B 76 9.9 RF00005 URS000080DFF5_562 32820061 0030533 0006412 562 cgcgggguggagcagccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<........>>>>.<<<<.........>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((........)))).(((...........))).....(((((.......)))))))))))..... Escherichia coli transcription-translation complex C4 (TTC-C4) containing mRNA with a 21 nt long spacer, transcription factor NusG, and fMet-tRNAs at P-site and E-site; E-site and P-site tRNA (fMet) 6vyx D 1521 9.9 RF00177,RF01959,RF01960 URS00000ABFE9_562 32820061 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccggccagcagcccgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgauaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgccguacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgaacaagguaaccguaggccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<......>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>..<<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>>.<<<<<(((...<<<<<.......)))........>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<......>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<......<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>..>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>......<<..<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>....>>........<<<<<<<<..>>>>>>>>...... ........((((..[.[[[[.)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((........))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..........)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((((.......)))))))).....)....)))))....)..((((([[[...(((((....(..]]]).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))..]]]].](((((.(((((((.((..(((((..((((((((((......((......))..........(((((((..(...((.((((..(((.(((....))).))).............))))..))).((.(.(...((((((.(....(((((((((....)))...(((......)))...))))))....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(.((..((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))....))..)..)..((((((((()))))))))}..... Escherichia coli transcription-translation complex C4 (TTC-C4) containing mRNA with a 21 nt long spacer, transcription factor NusG, and fMet-tRNAs at P-site and E-site; 16S rRNA 6vyx a 2880 9.9 RF02540,RF02541 URS0000B21DEA_562 32820061 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaacccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcggggcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacgguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccucccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccgaacaaacgguccuaagguagcgaaauccuugucggguaaguuccgacugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugagaugcaguguacccgcggcaagacggaaagaccccguaaccuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgggauaacaggcgauaccgcccaagaguucauaucgacggcgguguuuggcacucggucggcucaucacauccuggggcugaaguaggucccaaggguauggcguucgccauuuaaagugguacgcgagcggguuuagaacgucgugagacagucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<.<....<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>..>>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>>.>>...............<<....>>....>>.........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<.....>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>>.>>...>>>>>>>.>...<<<<<<<<<.......>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....[[[...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<.....>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>.>......>>>>>>>>..>>>>..<<<<......>>>>.........<..........<<<<<<.....>>>>>>....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<.......>>>>>..<<<<<<<<.<<<.<<......<.<<..<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<..<<.......<<<<<<<<....>>>>>>>>....>>............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>..............>>>....>>>........<<...<<<<<<...<<.......>>...>>>>>>.....>>......<<.<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<....>>>>>.....>>>>>..>...>>.>>....<.<<<<<....>>>.>>>....>>..>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]].>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((.(.....)).)))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((..(.........)...))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((.......)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(.((..(((..((((.......))))..))).....(..(((......))))..)).)...)))..))))).))...........]]].)...))))))))))...)))))))(((((..((....))..)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((.(((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....)))).)))))).))).))).....((.....)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.((..(((((((..(((........(((((..((....))...)))))........))))))))..))))....((......))...........((.........(((((.......))))).)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((....]}.)))))..((((((((.(((.((......(.((.((((..(((((.(((.(((((.(((((((((((.(.((.(..........(((...(((.......(((((((....)))))))....))).............))).).)).).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((.....[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}.......)))..).)))......(.((.(.((((((...((.......))...))))))...).))..)....(.((.((((((..(((((((((......))))))..))).(((((....))))).....)))))..)...)).).....(.(((((....))).)))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((.(....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Escherichia coli transcription-translation complex C4 (TTC-C4) containing mRNA with a 21 nt long spacer, transcription factor NusG, and fMet-tRNAs at P-site and E-site; 23S rRNA 6vyx d 120 9.9 RF00001 URS0000049E57_562 32820061 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. .(((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))).. Escherichia coli transcription-translation complex C4 (TTC-C4) containing mRNA with a 21 nt long spacer, transcription factor NusG, and fMet-tRNAs at P-site and E-site; 5S rRNA 6vyy A 76 9.9 RF00005 URS000080DFF5_562 32820061 0030533 0006412 562 cgcgggguggagcagccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((........)))).(((((.......))))).....(((((.......)))))))))))..... Escherichia coli transcription-translation complex C5 (TTC-C5) containing mRNA with a 21 nt long spacer, NusG, and fMet-tRNAs at E-site and P-site; E-site and P-site tRNA (fMet) 6vyy B 76 9.9 RF00005 URS000080DFF5_562 32820061 0030533 0006412 562 cgcgggguggagcagccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<........>>>>.<<<<.........>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((........)))).(((...........))).....(((((.......)))))))))))..... Escherichia coli transcription-translation complex C5 (TTC-C5) containing mRNA with a 21 nt long spacer, NusG, and fMet-tRNAs at E-site and P-site; E-site and P-site tRNA (fMet) 6vyy D 1522 9.9 RF00177,RF01959,RF01960 URS00000ABFE9_562 32820061 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccggccagcagcccgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgauaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgccguacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgaacaagguaaccguaggccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<......>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>..<<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>>.<<<<<(((...<<<<<.......)))........>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<......>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<......<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>..>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>......<<..<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>....>>........<<<<<<<<..>>>>>>>>...... ........((((..[.[[[[.)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((........))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..........)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((((.......)))))))).....)....)))))....)..((((([[[...(((((....(..]]]).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))..]]]].](((((.(((((((.((..(((((..((((((((((......((......))..........(((((((..(...((.((((..(((.(((....))).))).............))))..))).((.(.(...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(.((..((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))....))..)..)..((((((((()))))))))}..... Escherichia coli transcription-translation complex C5 (TTC-C5) containing mRNA with a 21 nt long spacer, NusG, and fMet-tRNAs at E-site and P-site; 16S rRNA 6vyy a 2880 9.9 RF02540,RF02541 URS0000B21DEA_562 32820061 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaacccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcggggcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacgguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccucccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccgaacaaacgguccuaagguagcgaaauccuugucggguaaguuccgacugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugagaugcaguguacccgcggcaagacggaaagaccccguaaccuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgggauaacaggcgauaccgcccaagaguucauaucgacggcgguguuuggcacucggucggcucaucacauccuggggcugaaguaggucccaaggguauggcguucgccauuuaaagugguacgcgagcggguuuagaacgucgugagacagucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<.<....<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>..>>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>>.>>...............<<....>>....>>.........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<.....>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>>.>>...>>>>>>>.>...<<<<<<<<<.......>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....[[[...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<.....>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>.>......>>>>>>>>..>>>>..<<<<......>>>>.........<..........<<<<<<.....>>>>>>....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<.......>>>>>..<<<<<<<<.<<<.<<......<.<<..<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<..<<.......<<<<<<<<....>>>>>>>>....>>............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>..............>>>....>>>........<<...<<<<<<...<<.......>>...>>>>>>.....>>......<<.<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<....>>>>>.....>>>>>..>...>>.>>....<.<<<<<....>>>.>>>....>>..>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]].>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((.(.....)).)))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((..(.........)...))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((.......)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(.((..(((..((((.......))))..))).....(..(((......))))..)).)...)))..))))).))...........]]].)...))))))))))...)))))))(((((..((....))..)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((.(((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....)))).)))))).))).))).....((.....)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.((..(((((((..(((........(((((..((....))...)))))........))))))))..))))....((......))...........((.........(((((.......))))).)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((....]}.)))))..((((((((.(((.((......(.((.((((..(((((.(((.(((((.(((((((((((.(.((.(..........(((...(((.......(((((((....)))))))....))).............))).).)).).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((.....[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}.......)))..).)))......(.((.(.((((((...((.......))...))))))...).))..)....(.((.((((((..(((((((((......))))))..))).(((((....))))).....)))))..)...)).).....(.(((((....))).)))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((.(....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Escherichia coli transcription-translation complex C5 (TTC-C5) containing mRNA with a 21 nt long spacer, NusG, and fMet-tRNAs at E-site and P-site; 23S rRNA 6vyy d 120 9.9 RF00001 URS0000049E57_562 32820061 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. .(((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))).. Escherichia coli transcription-translation complex C5 (TTC-C5) containing mRNA with a 21 nt long spacer, NusG, and fMet-tRNAs at E-site and P-site; 5S rRNA 6vyz A 76 9.9 RF00005 URS000080DFF5_562 32820061 0030533 0006412 562 cgcgggguggagcagccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((........)))).(((((.......))))).....(((((.......)))))))))))..... Escherichia coli transcription-translation complex C6 (TTC-C6) containing mRNA with a 21 nt long spacer, NusA, and fMet-tRNAs at E-site and P-site; E-site and P-site tRNA (fMet) 6vyz B 76 9.9 RF00005 URS000080DFF5_562 32820061 0030533 0006412 562 cgcgggguggagcagccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<........>>>>.<<<<.........>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((........)))).(((...........))).....(((((.......)))))))))))..... Escherichia coli transcription-translation complex C6 (TTC-C6) containing mRNA with a 21 nt long spacer, NusA, and fMet-tRNAs at E-site and P-site; E-site and P-site tRNA (fMet) 6vyz D 1522 9.9 RF00177,RF01959,RF01960 URS00000ABFE9_562 32820061 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccggccagcagcccgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgauaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgccguacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgaacaagguaaccguaggccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<......>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>..<<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>>.<<<<<(((...<<<<<.......)))........>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<......>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<......<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>..>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>......<<..<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>....>>........<<<<<<<<..>>>>>>>>...... ........((((..[.[[[[.)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((........))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..........)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((((.......)))))))).....)....)))))....)..((((([[[...(((((....(..]]]).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))..]]]].](((((.(((((((.((..(((((..((((((((((......((......))..........(((((((..(...((.((((..(((.(((....))).))).............))))..))).((.(.(...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(.((..((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))....))..)..)..((((((((()))))))))}..... Escherichia coli transcription-translation complex C6 (TTC-C6) containing mRNA with a 21 nt long spacer, NusA, and fMet-tRNAs at E-site and P-site; 16S rRNA 6vyz a 2880 9.9 RF02540,RF02541 URS0000B21DEA_562 32820061 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaacccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcggggcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacgguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccucccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccgaacaaacgguccuaagguagcgaaauccuugucggguaaguuccgacugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugagaugcaguguacccgcggcaagacggaaagaccccguaaccuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgggauaacaggcgauaccgcccaagaguucauaucgacggcgguguuuggcacucggucggcucaucacauccuggggcugaaguaggucccaaggguauggcguucgccauuuaaagugguacgcgagcggguuuagaacgucgugagacagucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<.<....<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>..>>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>>.>>...............<<....>>....>>.........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<.....>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>>.>>...>>>>>>>.>...<<<<<<<<<.......>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....[[[...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<.....>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>.>......>>>>>>>>..>>>>..<<<<......>>>>.........<..........<<<<<<.....>>>>>>....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<.......>>>>>..<<<<<<<<.<<<.<<......<.<<..<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<..<<.......<<<<<<<<....>>>>>>>>....>>............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>..............>>>....>>>........<<...<<<<<<...<<.......>>...>>>>>>.....>>......<<.<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<....>>>>>.....>>>>>..>...>>.>>....<.<<<<<....>>>.>>>....>>..>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]].>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((.(.....)).)))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((..(.........)...))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((.......)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(.((..(((..((((.......))))..))).....(..(((......))))..)).)...)))..))))).))...........]]].)...))))))))))...)))))))(((((..((....))..)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((.(((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....)))).)))))).))).))).....((.....)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.((..(((((((..(((........(((((..((....))...)))))........))))))))..))))....((......))...........((.........(((((.......))))).)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((....]}.)))))..((((((((.(((.((......(.((.((((..(((((.(((.(((((.(((((((((((.(.((.(..........(((...(((.......(((((((....)))))))....))).............))).).)).).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((.....[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}.......)))..).)))......(.((.(.((((((...((.......))...))))))...).))..)....(.((.((((((..(((((((((......))))))..))).(((((....))))).....)))))..)...)).).....(.(((((....))).)))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((.(....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Escherichia coli transcription-translation complex C6 (TTC-C6) containing mRNA with a 21 nt long spacer, NusA, and fMet-tRNAs at E-site and P-site; 23S rRNA 6vyz d 120 9.9 RF00001 URS0000049E57_562 32820061 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. .(((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))).. Escherichia coli transcription-translation complex C6 (TTC-C6) containing mRNA with a 21 nt long spacer, NusA, and fMet-tRNAs at E-site and P-site; 5S rRNA 6vz2 A 76 10.0 RF00005 URS000080DFF5_562 32820061 0030533 0006412 562 cgcgggguggagcagccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((........)))).(((((.......))))).....(((((.......)))))))))))..... Escherichia coli transcription-translation complex D1 (TTC-D1) containing mRNA with a 27 nt long spacer, NusG, and fMet-tRNAs at E-site and P-site; E-site and P-site tRNA (fMet) 6vz2 B 76 10.0 RF00005 URS000080DFF5_562 32820061 0030533 0006412 562 cgcgggguggagcagccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<........>>>>.<<<<.........>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((........)))).(((...........))).....(((((.......)))))))))))..... Escherichia coli transcription-translation complex D1 (TTC-D1) containing mRNA with a 27 nt long spacer, NusG, and fMet-tRNAs at E-site and P-site; E-site and P-site tRNA (fMet) 6vz2 D 1523 10.0 RF00177,RF01959,RF01960 URS00000ABFE9_562 32820061 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccggccagcagcccgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgauaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgccguacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgaacaagguaaccguagggccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<......>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>..<<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>>.<<<<<(((...<<<<<.......)))........>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<......>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<......<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>..>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>......<<..<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>....>>........<<<<<<<<<.>>>>>>>>>...... ........((((..[.[[[[.)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((........))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..........)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((((.......)))))))).....)....)))))....)..((((([[[...(((((....(..]]]).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))..]]]].](((((.(((((((.((..(((((..((((((((((......((......))..........(((((((..(...((.((((..(((.(((....))).))).............))))..))).((.(.(...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(.((..((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))....))..)..)..(((((((((.)))))))))}..... Escherichia coli transcription-translation complex D1 (TTC-D1) containing mRNA with a 27 nt long spacer, NusG, and fMet-tRNAs at E-site and P-site; 16S rRNA 6vz2 a 2880 10.0 RF02540,RF02541 URS0000B21DEA_562 32820061 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaacccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcggggcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacgguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccucccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccgaacaaacgguccuaagguagcgaaauccuugucggguaaguuccgacugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugagaugcaguguacccgcggcaagacggaaagaccccguaaccuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgggauaacaggcgauaccgcccaagaguucauaucgacggcgguguuuggcacucggucggcucaucacauccuggggcugaaguaggucccaaggguauggcguucgccauuuaaagugguacgcgagcggguuuagaacgucgugagacagucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<.<....<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>..>>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>>.>>...............<<....>>....>>.........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<.....>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>>.>>...>>>>>>>.>...<<<<<<<<<.......>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....[[[...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<.....>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>.>......>>>>>>>>..>>>>..<<<<......>>>>.........<..........<<<<<<.....>>>>>>....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<.......>>>>>..<<<<<<<<.<<<.<<......<.<<..<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<..<<.......<<<<<<<<....>>>>>>>>....>>............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>..............>>>....>>>........<<...<<<<<<...<<.......>>...>>>>>>.....>>......<<.<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<....>>>>>.....>>>>>..>...>>.>>....<.<<<<<....>>>.>>>....>>..>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]].>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((.(.....)).)))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((..(.........)...))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((.......)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(.((..(((..((((.......))))..))).....(..(((......))))..)).)...)))..))))).))...........]]].)...))))))))))...)))))))(((((..((....))..)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((.(((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....)))).)))))).))).))).....((.....)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.((..(((((((..(((........(((((..((....))...)))))........))))))))..))))....((......))...........((.........(((((.......))))).)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((....]}.)))))..((((((((.(((.((......(.((.((((..(((((.(((.(((((.(((((((((((.(.((.(..........(((...(((.......(((((((....)))))))....))).............))).).)).).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((.....[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}.......)))..).)))......(.((.(.((((((...((.......))...))))))...).))..)....(.((.((((((..(((((((((......))))))..))).(((((....))))).....)))))..)...)).).....(.(((((....))).)))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((.(....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Escherichia coli transcription-translation complex D1 (TTC-D1) containing mRNA with a 27 nt long spacer, NusG, and fMet-tRNAs at E-site and P-site; 23S rRNA 6vz2 d 120 10.0 RF00001 URS0000049E57_562 32820061 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. .(((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))).. Escherichia coli transcription-translation complex D1 (TTC-D1) containing mRNA with a 27 nt long spacer, NusG, and fMet-tRNAs at E-site and P-site; 5S rRNA 6vz3 A 76 8.9 RF00005 URS000080DFF5_562 32820061 0030533 0006412 562 cgcgggguggagcagccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((........)))).(((((.......))))).....(((((.......)))))))))))..... Escherichia coli transcription-translation complex D2 (TTC-D2) containing mRNA with a 27 nt long spacer; E-site tRNA (fMet) 6vz3 B 76 8.9 RF00005 URS000080DFF5_562 32820061 0030533 0006412 562 cgcgggguggagcagccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<........>>>>.<<<<.........>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((........)))).(((...........))).....(((((.......)))))))))))..... Escherichia coli transcription-translation complex D2 (TTC-D2) containing mRNA with a 27 nt long spacer; E-site tRNA (fMet) 6vz3 D 1523 8.9 RF00177,RF01959,RF01960 URS00021ED903_562 32820061 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccggccagcagcccgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgauaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgccguacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgaacaagguaaccguagggccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<......>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>..<<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>>.<<<<<(((...<<<<<.......)))........>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<......>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<......<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>..>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>......<<..<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>....>>........<<<<<<<<<.>>>>>>>>>...... ........((((..[.[[[[.)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((........))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..........)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((((.......)))))))).....)....)))))....)..((((([[[...(((((....(..]]]).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))..]]]].](((((.(((((((.((..(((((..((((((((((......((......))..........(((((((..(...((.((((..(((.(((....))).))).............))))..))).((.(.(...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(.((..((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))....))..)..)..(((((((((.)))))))))}..... Escherichia coli transcription-translation complex D2 (TTC-D2) containing mRNA with a 27 nt long spacer; 16S rRNA 6vz3 a 2880 8.9 RF02540,RF02541 URS00021ED972_562 32820061 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaacccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcggggcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacgguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccucccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccgaacaaacgguccuaagguagcgaaauccuugucggguaaguuccgacugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugagaugcaguguacccgcggcaagacggaaagaccccguaaccuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgggauaacaggcgauaccgcccaagaguucauaucgacggcgguguuuggcacucggucggcucaucacauccuggggcugaaguaggucccaaggguauggcguucgccauuuaaagugguacgcgagcggguuuagaacgucgugagacagucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<.<....<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>..>>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>>.>>...............<<....>>....>>.........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<.....>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>>.>>...>>>>>>>.>...<<<<<<<<<.......>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....[[[...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<.....>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>.>......>>>>>>>>..>>>>..<<<<......>>>>.........<..........<<<<<<.....>>>>>>....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<.......>>>>>..<<<<<<<<.<<<.<<......<.<<..<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<..<<.......<<<<<<<<....>>>>>>>>....>>............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>..............>>>....>>>........<<...<<<<<<...<<.......>>...>>>>>>.....>>......<<.<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<....>>>>>.....>>>>>..>...>>.>>....<.<<<<<....>>>.>>>....>>..>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]].>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((.(.....)).)))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((..(.........)...))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((.......)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(.((..(((..((((.......))))..))).....(..(((......))))..)).)...)))..))))).))...........]]].)...))))))))))...)))))))(((((..((....))..)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((.(((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....)))).)))))).))).))).....((.....)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.((..(((((((..(((........(((((..((....))...)))))........))))))))..))))....((......))...........((.........(((((.......))))).)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((....]}.)))))..((((((((.(((.((......(.((.((((..(((((.(((.(((((.(((((((((((.(.((.(..........(((...(((.......(((((((....)))))))....))).............))).).)).).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((.....[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}.......)))..).)))......(.((.(.((((((...((.......))...))))))...).))..)....(.((.((((((..(((((((((......))))))..))).(((((....))))).....)))))..)...)).).....(.(((((....))).)))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((.(....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Escherichia coli transcription-translation complex D2 (TTC-D2) containing mRNA with a 27 nt long spacer; 23S rRNA 6vz3 d 120 8.9 RF00001 URS0000049E57_562 32820061 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. .(((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))).. Escherichia coli transcription-translation complex D2 (TTC-D2) containing mRNA with a 27 nt long spacer; 5S rRNA 6vz5 A 76 8.9 RF00005 URS000080DFF5_562 32820061 0030533 0006412 562 cgcgggguggagcagccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((........)))).(((((.......))))).....(((((.......)))))))))))..... Escherichia coli transcription-translation complex D3 (TTC-D3) containing mRNA with a 21 nt long spacer, NusG, and fMet-tRNAs at E-site and P-site; E-site and P-site tRNA (fMet) 6vz5 B 76 8.9 RF00005 URS000080DFF5_562 32820061 0030533 0006412 562 cgcgggguggagcagccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<........>>>>.<<<<.........>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((........)))).(((...........))).....(((((.......)))))))))))..... Escherichia coli transcription-translation complex D3 (TTC-D3) containing mRNA with a 21 nt long spacer, NusG, and fMet-tRNAs at E-site and P-site; E-site and P-site tRNA (fMet) 6vz5 D 1523 8.9 RF00177,RF01959,RF01960 URS00000ABFE9_562 32820061 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccggccagcagcccgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgauaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgccguacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgaacaagguaaccguagggccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<......>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>..<<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>>.<<<<<(((...<<<<<.......)))........>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<......>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<......<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>..>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>......<<..<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>....>>........<<<<<<<<<.>>>>>>>>>...... ........((((..[.[[[[.)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((........))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..........)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((((.......)))))))).....)....)))))....)..((((([[[...(((((....(..]]]).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))..]]]].](((((.(((((((.((..(((((..((((((((((......((......))..........(((((((..(...((.((((..(((.(((....))).))).............))))..))).((.(.(...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(.((..((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))....))..)..)..(((((((((.)))))))))}..... Escherichia coli transcription-translation complex D3 (TTC-D3) containing mRNA with a 21 nt long spacer, NusG, and fMet-tRNAs at E-site and P-site; 16S rRNA 6vz5 a 2880 8.9 RF02540,RF02541 URS0000B21DEA_562 32820061 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaacccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcggggcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacgguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccucccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccgaacaaacgguccuaagguagcgaaauccuugucggguaaguuccgacugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugagaugcaguguacccgcggcaagacggaaagaccccguaaccuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgggauaacaggcgauaccgcccaagaguucauaucgacggcgguguuuggcacucggucggcucaucacauccuggggcugaaguaggucccaaggguauggcguucgccauuuaaagugguacgcgagcggguuuagaacgucgugagacagucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<.<....<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>..>>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>>.>>...............<<....>>....>>.........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<.....>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>>.>>...>>>>>>>.>...<<<<<<<<<.......>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....[[[...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<.....>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>.>......>>>>>>>>..>>>>..<<<<......>>>>.........<..........<<<<<<.....>>>>>>....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<.......>>>>>..<<<<<<<<.<<<.<<......<.<<..<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<..<<.......<<<<<<<<....>>>>>>>>....>>............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>..............>>>....>>>........<<...<<<<<<...<<.......>>...>>>>>>.....>>......<<.<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<....>>>>>.....>>>>>..>...>>.>>....<.<<<<<....>>>.>>>....>>..>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]].>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((.(.....)).)))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((..(.........)...))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((.......)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(.((..(((..((((.......))))..))).....(..(((......))))..)).)...)))..))))).))...........]]].)...))))))))))...)))))))(((((..((....))..)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((.(((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....)))).)))))).))).))).....((.....)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.((..(((((((..(((........(((((..((....))...)))))........))))))))..))))....((......))...........((.........(((((.......))))).)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((....]}.)))))..((((((((.(((.((......(.((.((((..(((((.(((.(((((.(((((((((((.(.((.(..........(((...(((.......(((((((....)))))))....))).............))).).)).).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((.....[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}.......)))..).)))......(.((.(.((((((...((.......))...))))))...).))..)....(.((.((((((..(((((((((......))))))..))).(((((....))))).....)))))..)...)).).....(.(((((....))).)))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((.(....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Escherichia coli transcription-translation complex D3 (TTC-D3) containing mRNA with a 21 nt long spacer, NusG, and fMet-tRNAs at E-site and P-site; 23S rRNA 6vz5 d 120 8.9 RF00001 URS0000049E57_562 32820061 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. .(((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))).. Escherichia coli transcription-translation complex D3 (TTC-D3) containing mRNA with a 21 nt long spacer, NusG, and fMet-tRNAs at E-site and P-site; 5S rRNA 6vz7 A 76 7.0 RF00005 URS000080DFF5_562 32820061 0030533 0006412 562 cgcgggguggagcagccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((........)))).(((((.......))))).....(((((.......)))))))))))..... Escherichia coli transcription-translation complex C1 (TTC-C1) containing a 27 nt long mRNA spacer, NusG, and fMet-tRNAs at P-site and E-site; E-site and P-site tRNA (fMet) 6vz7 B 76 7.0 RF00005 URS000080DFF5_562 32820061 0030533 0006412 562 cgcgggguggagcagccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<........>>>>.<<<<.........>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((........)))).(((...........))).....(((((.......)))))))))))..... Escherichia coli transcription-translation complex C1 (TTC-C1) containing a 27 nt long mRNA spacer, NusG, and fMet-tRNAs at P-site and E-site; E-site and P-site tRNA (fMet) 6vz7 D 1524 7.0 RF00177,RF01959,RF01960 URS00000ABFE9_562 32820061 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccggccagcagcccgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgauaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgccguacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgaacaagguaaccguaggggccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<......>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>..<<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>>.<<<<<(((...<<<<<.......)))........>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<......>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<......<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>..>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>......<<..<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>....>>........<<<<<<<<<..>>>>>>>>>...... ........((((..[.[[[[.)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((........))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..........)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((((.......)))))))).....)....)))))....)..((((([[[...(((((....(..]]]).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))..]]]].](((((.(((((((.((..(((((..((((((((((......((......))..........(((((((..(...((.((((..(((.(((....))).))).............))))..))).((.(.(...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..(..((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))....)...)..)..(((((((((..)))))))))}..... Escherichia coli transcription-translation complex C1 (TTC-C1) containing a 27 nt long mRNA spacer, NusG, and fMet-tRNAs at P-site and E-site; 16S rRNA 6vz7 a 2880 7.0 RF02540,RF02541 URS00021ED9BC_562 32820061 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaacccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcggggcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacgguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccucccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccgaacaaacgguccuaagguagcgaaauccuugucggguaaguuccgacugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugagaugcaguguacccgcggcaagacggaaagaccccguaaccuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgggauaacaggcgauaccgcccaagaguucauaucgacggcgguguuuggcacucggucggcucaucacauccuggggcugaaguaggucccaaggguauggcguucgccauuuaaagugguacgcgagcggguuuagaacgucgugagacagucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<.<....<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>..>>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>>.>>...............<<....>>....>>.........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<.....>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>>.>>...>>>>>>>.>...<<<<<<<<<.......>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....[[[...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<.....>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>.>......>>>>>>>>..>>>>..<<<<......>>>>.........<..........<<<<<<.....>>>>>>....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<.......>>>>>..<<<<<<<<.<<<.<<......<.<<..<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<..<<.......<<<<<<<<....>>>>>>>>....>>............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>..............>>>....>>>........<<...<<<<<<...<<.......>>...>>>>>>.....>>......<<.<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<....>>>>>.....>>>>>..>...>>.>>....<.<<<<<....>>>.>>>....>>..>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]].>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((.(.....)).)))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((..(.........)...))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((.......)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(.((..(((..((((.......))))..))).....(..(((......))))..)).)...)))..))))).))...........]]].)...))))))))))...)))))))(((((..((....))..)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((.(((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....)))).)))))).))).))).....((.....)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.((..(((((((..(((........(((((..((....))...)))))........))))))))..))))....((......))...........((.........(((((.......))))).)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((....]}.)))))..((((((((.(((.((......(.((.((((..(((((.(((.(((((.(((((((((((.(.((.(..........(((...(((.......(((((((....)))))))....))).............))).).)).).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((.....[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}.......)))..).)))......(.((.(.((((((...((.......))...))))))...).))..)....(.((.((((((..(((((((((......))))))..))).(((((....))))).....)))))..)...)).).....(.(((((....))).)))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((.(....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Escherichia coli transcription-translation complex C1 (TTC-C1) containing a 27 nt long mRNA spacer, NusG, and fMet-tRNAs at P-site and E-site; 23S rRNA 6vz7 d 120 7.0 RF00001 URS0000049E57_562 32820061 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. .(((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))).. Escherichia coli transcription-translation complex C1 (TTC-C1) containing a 27 nt long mRNA spacer, NusG, and fMet-tRNAs at P-site and E-site; 5S rRNA 6vzj 7 32 4.1 32820061 32630 auguuuuuuuuuuuuuuugauuuggugagagg ................................ ................................ Escherichia coli transcription-translation complex A1 (TTC-A1) containing mRNA with a 15 nt long spacer, fMet-tRNAs at E-site and P-site, and lacking transcription factor NusG; mRNA with 27 nt long spacer 6vzj A 76 4.1 RF00005 URS000080DFF5_562 32820061 0030533 0006412 562 cgcgggguggagcagccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((........)))).(((((.......))))).....(((((.......)))))))))))..... Escherichia coli transcription-translation complex A1 (TTC-A1) containing mRNA with a 15 nt long spacer, fMet-tRNAs at E-site and P-site, and lacking transcription factor NusG; E-site and P-site tRNA (fMet) 6vzj B 76 4.1 RF00005 URS000080DFF5_562 32820061 0030533 0006412 562 cgcgggguggagcagccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<........>>>>.<<<<.........>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((........)))).(((...........))).....(((((.......)))))))))))..... Escherichia coli transcription-translation complex A1 (TTC-A1) containing mRNA with a 15 nt long spacer, fMet-tRNAs at E-site and P-site, and lacking transcription factor NusG; E-site and P-site tRNA (fMet) 6vzj D 1524 4.1 RF00177,RF01959,RF01960 URS00000ABFE9_562 32820061 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccggccagcagcccgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgauaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgccguacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgaacaagguaaccguaggggccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<......>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>..<<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>>.<<<<<(((...<<<<<.......)))........>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<......>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<......<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>..>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>......<<..<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>....>>........<<<<<<<<<..>>>>>>>>>...... ........((((..[.[[[[.)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((........))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..........)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((((.......)))))))).....)....)))))....)..((((([[[...(((((....(..]]]).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))..]]]].](((((.(((((((.((..(((((..((((((((((......((......))..........(((((((..(...((.((((..(((.(((....))).))).............))))..))).((.(.(...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..(..((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))....)...)..)..(((((((((..)))))))))}..... Escherichia coli transcription-translation complex A1 (TTC-A1) containing mRNA with a 15 nt long spacer, fMet-tRNAs at E-site and P-site, and lacking transcription factor NusG; 16S rRNA 6vzj a 2880 4.1 RF02540,RF02541 URS0000B21DEA_562 32820061 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaacccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcggggcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacgguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccucccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccgaacaaacgguccuaagguagcgaaauccuugucggguaaguuccgacugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugagaugcaguguacccgcggcaagacggaaagaccccguaaccuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgggauaacaggcgauaccgcccaagaguucauaucgacggcgguguuuggcacucggucggcucaucacauccuggggcugaaguaggucccaaggguauggcguucgccauuuaaagugguacgcgagcggguuuagaacgucgugagacagucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<.<....<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>..>>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>>.>>...............<<....>>....>>.........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<.....>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>>.>>...>>>>>>>.>...<<<<<<<<<.......>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....[[[...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<.....>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>.>......>>>>>>>>..>>>>..<<<<......>>>>.........<..........<<<<<<.....>>>>>>....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<.......>>>>>..<<<<<<<<.<<<.<<......<.<<..<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<..<<.......<<<<<<<<....>>>>>>>>....>>............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>..............>>>....>>>........<<...<<<<<<...<<.......>>...>>>>>>.....>>......<<.<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<....>>>>>.....>>>>>..>...>>.>>....<.<<<<<....>>>.>>>....>>..>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]].>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((.(.....)).)))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((..(.........)...))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((.......)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(.((..(((..((((.......))))..))).....(..(((......))))..)).)...)))..))))).))...........]]].)...))))))))))...)))))))(((((..((....))..)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((.(((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....)))).)))))).))).))).....((.....)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.((..(((((((..(((........(((((..((....))...)))))........))))))))..))))....((......))...........((.........(((((.......))))).)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((....]}.)))))..((((((((.(((.((......(.((.((((..(((((.(((.(((((.(((((((((((.(.((.(..........(((...(((.......(((((((....)))))))....))).............))).).)).).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((.....[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}.......)))..).)))......(.((.(.((((((...((.......))...))))))...).))..)....(.((.((((((..(((((((((......))))))..))).(((((....))))).....)))))..)...)).).....(.(((((....))).)))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((.(....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Escherichia coli transcription-translation complex A1 (TTC-A1) containing mRNA with a 15 nt long spacer, fMet-tRNAs at E-site and P-site, and lacking transcription factor NusG; 23S rRNA 6vzj d 120 4.1 RF00001 URS0000049E57_562 32820061 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. .(((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))).. Escherichia coli transcription-translation complex A1 (TTC-A1) containing mRNA with a 15 nt long spacer, fMet-tRNAs at E-site and P-site, and lacking transcription factor NusG; 5S rRNA 6w2s A 1697 3.47 RF01960,RF01959,RF00177 URS0000D56C41_9986 32286223 0003735 0005840 9986 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucgacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgcccggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcggccguccccugcucggcgccggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgaccccggucggcguaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggugcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<..<.....<<<.<....<<....<<<<.........<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<<<....>>>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<...<...>..>>>>..>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>>>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....<<<<<<<<..<<<....>>>...>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<....<<<.<<<..>>>.>>>.<<<<<<.<<..>>>>>>.>>..<<<<<<.<.......<<...<.......>.<<<<.>>>>...>>......>.>>>..>>>........<.<<.<<<<<<<...............>>>>>>>.>>.>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<...<<<.<<<<<<......<<........>>..........<<<<<......<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<..>>>>.>>>>>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.......>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<.....<<<<<..........>>>>>.....>......>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<.<<<<<<<<<..>>>>>>>>>...>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..((....((((....((...((.....((.(((.....))).))......))......)).((((...((.(((....)).)))...))))((..(((((...(......)..)))))......)).(.((((.(.((.)).)))))).).)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).).....((((((..(.((.(...)))..)..))).)))....(.((..(...........)..))......)..((((([[......((((.....((..]])).......)))).)))))..)))))).)))..[......(.([[...(.(.((...(((..(....(((..((()))..))).((((((.((..)))))).))..((((((.(.......((..((.......)).(((.)))....))......).)))..)))........(.((.(((((((...............))))))).)).)....)....(((..((..(...((((..((..((((((((...((........))......))))))))..)).......((....))...))))..)..))...))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.(((........))))))))).)..)))...((..]]))...))...].))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((........((..((........))..))......)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((...(...(.((..((((((((..((..))...))))))))..)).)..).....(((((.....)))))........)))....))).))).....).))))).....).)))))...)).)))).))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(..(((((((.(((..((((.((...(((((.(((.((((....))).))))...)))))...)).))))..))).))))))).)..)).))))...).))...)..)..(((((((((....)))))))))}........ Structure of the Cricket Paralysis Virus 5-UTR IRES (CrPV 5-UTR-IRES) bound to the small ribosomal subunit in the open state (Class 1); 18S rRNA 6w2s 0 339 3.47 URS0001A16A8D_12136 32286223 12136 uucgauaccaagagcuggugucugagggauuacgacucgcguggucggacagcacauguuagucauguauuaugguguuucccaacacguaucuuugcucuaguauugaacuuuagugaugaguguacuuggcauguacaccugauuaguuagcccuuguggauacgccacugccgcucagguacaguaggacauaccccaaauauuggguuuuuuuuuuagagaagaaaauuaguggcgaaacguacgguuuaugucaaaggagaaggugauuuuaauugcaccugaagcaacccuaggucuucccuuugaugugagcuaauaaggaguaaccgauuc .<<<<<<<...<<<<.<<.......<<<<....<.<......>.>......<.........................>.>>>>.........>>..>>>>..>>>>>>>..............<.<...........>.>........................<.<.....<<<..<........>..>>.>....<<<<.....>>>>...>.>....................<<..........<<<<<<<<<<<.<<....<<<..............>>>.....................>>>>>>>>>>>>>............>>..... .((.((....(((((.((...(...(((.....(.(......).)......(............(....)........).))).....)...))..)))))...)).))...............((((.......)))).........................(.(......((..............))......((((.....))))...).)....................((.....(.....(.(((((((.(..(...(..................)....(........)......)..)))))))).)......)......))..... Structure of the Cricket Paralysis Virus 5-UTR IRES (CrPV 5-UTR-IRES) bound to the small ribosomal subunit in the open state (Class 1); CrPV 5'-UTR IRES 6w2t a 1697 3.36 RF01960,RF01959,RF00177 URS0000D56C41_9986 32286223 0003735 0005840 9986 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucgacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgcccggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcggccguccccugcucggcgccggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgaccccggucggcguaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggugcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<....<<....<<<<<........<<.....<<.<<.......>>.>>......>>.........<<<<...<<<<<<....>>>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<...<<.>>..>>>>.>>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>...<<....>>.....>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....<<<<<<<<..<<......>>...>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<....<<<.<<<..>>>.>>>.<<<<<<.<<..>>>>>>.>>..<<<<<<.<.......<<...<.......>.<<<<.>>>>...>>......>.>>>..>>>........<.<<.<<<<<<<...............>>>>>>>.>>.>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>.>.>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<<....>>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<........<<........>>..........<<<<<......<<<<<........<<.<<<........>>>.>>......>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<..>>>>.>>>>>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>>......>>>>>......>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<.<<<<<<<<<..>>>>>>>>>...>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..((....(((.....((...((.....((.(((.....))).))......))......)).((((...((.((......).)))...))))((..(((((...(......)..)))))......)).(.((((...((.))..)))))...)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).)......(((.((((.((......))..)))).).)).....(.((..(...........)..))......)..((((([[......((((.....((..]])).......)))).)))))..)))))).)))..[......(.([[...(.(.((...(((..(....(((..((()))..))).((((((.((())))))).))..((((((.(.......((..((.......)).(((.)))....))......).)))..)))........(.((.(((((((...............))))))).)).)....)....(((.((...(...((((..(((.((((((((...((........))......)))))))).))).......((....))...))))..)...))..))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.(((((....))))))))))).)..)))...((..]]))...))...].))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((.......(........)...........(((((.(....((((.........((..((........))..)).......))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((...(...((((..((((((((((((..)))).))))))))..))))..).....(((((.....)))))........)))....))).))).....).))))).....).)))))...)).)))).))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((....((((((((.(((..((((.((...(((((..((.(.(((..)))..)).)...)))))...)).))))..))).))))))))...)).))))...).))...)..)..(((((((((....)))))))))}........ Structure of the Cricket Paralysis Virus 5-UTR IRES (CrPV 5-UTR-IRES) bound to the small ribosomal subunit in the closed state (Class 2); 18S rRNA 6w2t A 339 3.36 URS0001A16A8D_12136 32286223 12136 uucgauaccaagagcuggugucugagggauuacgacucgcguggucggacagcacauguuagucauguauuaugguguuucccaacacguaucuuugcucuaguauugaacuuuagugaugaguguacuuggcauguacaccugauuaguuagcccuuguggauacgccacugccgcucagguacaguaggacauaccccaaauauuggguuuuuuuuuuagagaagaaaauuaguggcgaaacguacgguuuaugucaaaggagaaggugauuuuaauugcaccugaagcaacccuaggucuucccuuugaugugagcuaauaaggaguaaccgauuc ..<<<<<<...<<<<.<<...<...<<<.....<.<......>.>......<.........................>..>>>.....>...>>..>>>>..>>>>>>...............<<<<.........>>>>......................<.<.<......<<..<........>..>>......<<<<.....>>>>...>.>.>..................<<.....<....<<<<<<<<<<<.<<.....<................>.<................>...>>>>>>>>>>>>>.....>......>>..... (((.((......(((.((...(...(((.....(.(......).)...................................))).....)...))..))).....)).))).............(((((.......)))))........................(........((..............))......((((.....)))).....)....................((.....(.....(((((((((.((((...........................(........)......)))))))))))))......)......))..... Structure of the Cricket Paralysis Virus 5-UTR IRES (CrPV 5-UTR-IRES) bound to the small ribosomal subunit in the closed state (Class 2); CrPV 5'-UTR IRES 6w6l D 157 3.84 RF00002 URS0000005270_9606 32820719 0003735 0005840 9606 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcuu .........................................<<<<<<.<<.....>>>.......<<<......>>.............>>>......>>>....<<....>><<<<<<<<.......>>>>>>>>..................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....)).((((((.........))))))...................... Cryo-EM structure of the human ribosome-TMCO1 translocon; 5.8S ribosomal RNA 6w6l E 119 3.84 RF00001 URS000064027A_9606 32820719 0003735 0005840 9606 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>. (((((((((....((((((((.....((..((...(....)...))....))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))). Cryo-EM structure of the human ribosome-TMCO1 translocon; 5S ribosomal RNA 6w6l t 3510 3.84 RF02540,RF02543 URS00021ED91A_9606 32820719 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgcgcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcggcccggcggaucuuucccgggcgggggaccgucccccggaccggcgaccggccgccgccgggcgcauuuccaggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucggggcccccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagagacccgucgccgcgcucuccccccugggggggccgggccaccccucccacggcgcgaccgcucucccagggggcggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccggggggccacgcgcgcgucccccgaagggggggacggcggagagcgcacggggucggcggcgacgucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgaggggcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcccacgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcgucgagaguggacgggagcggcggcccggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcuggcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacguuuuuucacugacccggugaggcgggggggcgagcccgaggggcucucgcuucuggcgccaagcgcccgcccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucgccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccgguccccgccggggguccggugcggagugcccuucguccugggaaaccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuuguc .........................<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..[[[..<...<.....<<<<<..........>>>>>.......>..>...<.<<..<<.....<.<.<.........<<<<........<.<........>.>..................................>>>>....>..>>....>>..>>.>.......<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<......>>>..................................<<<<<<<<..<<<..........<<.<.<<<<....<<.<..<..<.........<....<<.......<<<<.<<<..<<<<..>>>>>>>>>>>..>>....>..........>..>..>.>>....>>>>.>.>>.....<<<<<<<<.<<<<<<<<<<.<<<........<<<.<<.<<<.......<<<<<<<<.>>>>>>>>........>>>.>>>>>...........>>>...>>>>>>>>>>.........................<<<<<<..>>>>>>....<<.......<<...<....<.<<<<<...<<...>>.<<<<<<<.<<<<....>>>>.>>>>>>>>>>>>.>....>....>>.........>>..........<<<<<<....>>>>>>....................>>>.>>>>>....>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<......>>>>>>>..<<<<<..<<<...<.....[[.......>...>>>...>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<........<<<.<<<<<<<<<...<<<....<<...<.<<<<..<.<<<.........>>>.>>>>>.>...>>..>.>>...>>>>>>>....<<<<<<<<.........>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<............>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<................]].....<.....>...................>.>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<<....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<<<<<...>>>>>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<...<<<<<<<....>>>>>>>...<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..{{{..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<...............>>>>><<.<<<<<<<<<<<.>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<...<.<<<<....>>>>.>...>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>...>>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<<.<<<<<<<<<..>>>>>>>>>...<<<<<.....<<<<...<.<<...........>>>...............<<<<<<<......>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>><<<<....>>>>>>))).......((((((..(((..>>>>>>.)))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>.>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]].....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<}}}.>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>......<<<<<<.<<..<<<..<..<.............<.<<<<....>>>>.>.............>....<<<..<<<<........>>>>..>>>..........>...>>>...>>>>>>>>.<<<<<.<.............>.....<.<<<<<<<.<<.....<<<<....<<<<<......>>>>>...>>>>....>>....>>>>.>>>.>...>>>>>... .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.....(.....(((((..........))))).......)......(.((..((.(...(........(....((((..........(........).........(...)...(........).........))))..).....)...)))..)).)..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((..(....(..((.(...((....((.(..(..(.....(.(.(...(((.(....(((((.((...((((..)))).)))))))))).)..).)....)...)..)..).))....))...).))..)...(((((((.((((.(((((.(((........(((.((.(((.......((((((((.))))))))........))).)))))...........)))...))))).)))).......................(.((((((()))))))...(.(...(((.((...(....(.((((.(..((...))..((((((.((((....)))).))))))).)))).)....)....))....))).).)..........((((((....))))))..........).........))).))))...).)))...)))))))).[((((........))))((((((....(((((((((((((..(((..(((((........))))..)..)))...((....))...(((((((......)))))))..(((((...((...(..............)...))....))))).(((((((((.((((......))))))))))).))....)))))))))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((........(((.((((((((....(((....(((..(.((((.(.(.((.(.....).)).)))))).)..)))..)).)....))))))....((((((((.(......)))))))))....))))))))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.(.((((((((............)))))))).))))..........]]].)....))))))))))...)))))))((((((.(.................................................).))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((..(((((((....(.....)..))))))....[[(((.((...((..(.(((....))).....)....((.(((((((((...)))))))))))......))....))...(.(((........))).)]]((((....(((((...(((((((....)))))))..((((....)))...(...((((.(...(((((((((((((((((((((((..{{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....).))))...)).........)).))).)))).))).))).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((.)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.....((.....((((....)))).....))..))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.(((((((((.(((((.(((()))).)))))...(((((.....((((..(..................)..............(((((((......)))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}}.)))))..)).))...))))...)))).((((...((((.............))))...))))..)))...).))))))......(((((..((..((......(.............(..(((....)))..)..............)...(((..((((........))))..)))...............))...)).))))).(((((.(..(.......)..).....(.(((((((.((.....((((.(..(((((......)))))..)))))....))....)))).))).)...)))))... Cryo-EM structure of the human ribosome-TMCO1 translocon; 28S ribosomal RNA 6w6l u 75 3.84 RF00005 URS0000EEAD11_9606 32820719 0030533 0006412 9606 cccggauagcucagucgguagagcaggggauuccguauccccguguccuugguucgauuccgaguccgggcacca <<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>..... .(((((..((.(........).))..((((.......))))......((.((.......)).)))))))...... Cryo-EM structure of the human ribosome-TMCO1 translocon; tRNA 6w6p a 1523 2.9 RF00177,RF01959,RF01960 URS00021ED9C4_474186 33004869 0003735 0005840 474186 ugagaguuugauccuggcucaggacgaacgcuggcggcgugccuaauacaugcaagucgaacgcuucuuggaaagaggaguggcggacgggugaguaacacguggguaaccuacccaucagagggggauaacacuuggaaacaggugcuaauaccgcauaacaguuuaugccgcauggcauaagagugaaaggcgcuuucgggugucgcugauggauggacccgcggugcauuagcuaguuggugagguaacggcucaccaaggccacgaugcauagccgaccugagagggugaucggccacacugggacugagacacggcccagacuccuacgggaggcagcaguagggaaucuucggcaauggacgaaagucugaccgagcaacgccgcgugagugaagaagguuuucggaucguaaaacucuguuguuagagaagaacaaggacguuaguaacugaacguccccugacgguaucuaaccagaaagccacggcuaacuacgugccagcagccgcgguaauacguagguggcaagcguuguccggauuuauugggcguaaagcgagcgcaggcgguuucuuaagucugaugugaaagcccccggcucaaccggggagggucauuggaaacugggagacuugagugcagaagaggagaguggaauuccauguguagcggugaaaugcguagauauauggaggaacaccaguggcgaaggcggcucucuggucuguaacugacgcugaggcucgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugagugcuaaguguuggaggguuuccgcccuucagugcugcagcaaacgcauuaagcacuccgccuggggaguacgaccgcaagguugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggucuugacauccuuugaccacucuagagauagagcuuucccuucggggacaaagugacagguggugcaugguugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuuauuguuaguugccaucauuuaguugggcacucuagcgagacugccggugacaaaccggaggaagguggggaugacgucaaaucaucaugccccuuaugaccugggcuacacacgugcuacaaugggaaguacaacgagucgcuagaccgcgaggucaugcaaaucucuuaaagcuucucucaguucggauugcaggcugcaacucgccugcaugaagccggaaucgcuaguaaucgcggaucagcacgccgcggugaauacguucccgggccuuguacacaccgcccgucacaccacgagaguuuguaacacccgaagucggugagguaaccuuuuuggagccagccgccuaaggugggauagaugauuggggugaagucguaacaagguagccguaucggaaggugcggcuggauca ...<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<<<<<...>>>>>>.>>>>>......<<........<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<<....>>>>>>......>>.>.......<<<<<<<<<..>>>>>>>>>.......<<<<<<....>>>>>>.>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<<<<<<<.........<<<<<<<........>>>>>>>..........>>>>>>...>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<.......<<<<<<.....>>>>>>.....>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<<..<<<......>>>.....>>>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<......>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<.....<<<<<....>>>>>................>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<......>>>>>...>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<..<<<<...<<.<<<<..<<<..<<.....>>.>>>.>>>>.>>..>>>>..>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ...((((..[.[[[..)))).(((..(((((..(((((((((....(((.(((..(((..((.((((((...)))))).)))))......(((.......(((((((..((...(((((((.(.((.....((((((....))))))......)).).......((((((((....)))))))).......((((((....)))))).)))))))..))))))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....((((((...(.....((((.((........)).)))).....)....))))))......((((([[[...(((((.....((.]]])).......))))))))))..))))).)))..........((([....(.((((...(((.(((((((.((((((((((......((((((.....))))))...).)))))))..)))))))))..(((.(((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))))..))..))))...))))....((((((...((...((((.........))))...))))))))..........((((((..((((((((((((......))))))))))))...((...])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((......(((((....)))))......((....))...))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(........))))...)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((..((((....(.((((..(((..((.....)).))).)))).)...))))..))))))..))).))))..).))...)..)..(((((((((....)))))))))...... MultiBody Refinement of 70S Ribosome from Enterococcus faecalis; 16S rRNA 6w6p A 2739 2.9 RF02540,RF02541,RF00002 URS00021ED8E8_474186 33004869 0003735 0005840 474186 uuaagugaauaagggcgcacgguggaugccuuggcacuaggagccgaugaaggacgggacuaacaccgauaugcuuuggggagcuguaaguaagcuaugauccagagauuuccgaaugggggaacccaauaucuuuuauaggauauuacuuuucagugaauacauagcugauuagagguagacgcagagaacugaaacaucuuaguaccugcaggaagagaaagaaaauucgauucccugaguagcggcgagcgaaacgggaagagcccaaaccaacaagcuugcuuguugggguuguaggacuccgauaugguagucuguuaguauaguugaaggauuuggaaaauuccgcuaaagagggugaaagccccguagacgaaaugcugacaacaccuaggaggauccugaguacggcggaacacgagaaauuccgucggaauccgcggggaccaucccgcaaggcuaaauacucccuagugaccgauagugaaccaguaccgugagggaaaggugaaaagcaccccggaaggggagugaaauagauccugaaaccgugugccuacaacaagucaaagcucguuaaugagugauggcgugccuuuuguagaaugaaccggcgaguuacgauugcaugcgagguuaagucgaagagacggagccgcagcgaaagcgagucugaauagggcgaaugaguauguagucguagacccgaaaccaugugaucuacccauguccagguugaaggugcgguaaaacgcacuggaggaccgaacccacguacguugaaaagugcggggaugagguguggguagcggagaaauuccaaacgaacuuggagauagcugguucucuccgaaauagcuuuagggcuagccucggaauugagaaugauggagguagagcacuguuuggacuaguucagauaaacuccgaaugccauucauuuauauccgggagucagacugcgagugauaagauccguagucgaaagggaaacagcccagaccaccagcuaaggucccaaaauauauguuaaguggaaaaggaugugggguugcacagacaacuaucgagugacccugcgccgaaaauguaccggggcuaaacauauuaccgaagcuguggacuacaccauuagguguagugguaggagagcguucuaagggcguugaaggucgaucgugaggacggcuggagcgcuuagaagugagaaugccgguaugaguagcgaaagacaggugagaauccuguccaccguaugacuaagguuuccuggggaaggcucguccgcccaggguuagucgggaccuaagccgaggccgauaggcguaggcgauggacaacagguugauauuccuguaccaguuguuuguuugagcaauggagggacgcaguaggcuaaggaaugcaugcgauuggaagugcauguccaagcaaugagucuugaguagaguuaaaugcuuuacucuuuaaggacaaguugugacggggagcgaaauaguagcgaaguuccugacgucacacugccaagaaaagcuucuagugagaaaacaacugcccguaccguaaaccgacacagguagucgaggagaguauccuaaggugagcgagcgaacucucguuaaggaacucggcaaaaugaccccguaacuucgggagaaggggugcugacuucggucagccgcagugaauaggcccaagcgacuguuuaucaaaaacacaggucucugcaaaaucguaagaugaaguauaggggcugacgccugcccggugcuggaagguuaagaggauggguuagcuucggcgaagcucagaauugaagccccaguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgacccgcacgaaaggcguaacgauuugggcacugucucaacgagagacucggugaaauuuuaguaccugugaagaugcagguuacccgcgacaggacggaaagaccccauggagcuuuacuguaguuugauauugaguguuuaacccucuaacccgcaccacuaaucguggugggagacagugucagaugggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguucccucagaaugguuggaaaucauucgaagaguguaaaggcagaagggagcuugacugcgagaccuacaagucgagcagggacgaaagucgggcuuagugauccggugguuccgcauggaagggccaucgcucaacggauaaaagcuacccuggggauaacaggcuuaucucccccaagaguccacaucgacggggagguuuggcaccucgaugucggcucgucgcauccuggggcuguagucggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucccuauccgucgcgggcguuggaaauuugagaggagcuguccuuaguacgagaggaccgggauggacuuaccgcugguguaccaguuguucugccaagggcauugcuggguagcuauguagggaagggauaaacgcugaaagcaucuaagugugaagcccaccucaagaugagauuucccauuucuuuaagaaaguaagaccccugagagaugaucagguagauagguuggaaguggaaggcuagugauaguuggagcggaccaauacuaaucggucgaggacuuaac <<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<..<<<<<.........>>>>>..>>.>>....<<<<<......<<....>>.......>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..(((....<<<<<<<<....>>>>>>>>......<<<<<<<<...<.<<<.<<.<<<<<<<<<.<<<...<<<.<......>.>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>>.>>>>..>>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<....>>>>..................>>>>>>>>>>>.......<<<<..<<<<......>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>......>>>>>>>>>>>>>..<<.<..<<<<.<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>.>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<..<..<<<<<<<<<.....<<<...<<<<<<<<....>>>>>>>>..>>.>.....>>>>.>>>>>..>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<...>....>>>>>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<......>>>>>>>....>>>>>><.<<<<<<<.<<......<<<<<.<<....>>.>>>>>...>>.>>>>>>>..>.....>>>>>><......<<....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<.........<...<<<<....<<<<..<<<..<<<<<...........{...........<<..<<<<<..<<<<.<<<<<<<<<.....>>>>>>>>>.....>>>>..>>>>>...>>...<<.........>>....>>>>>...>>>...>>>>.........>>>>..>.......>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<....>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<..<<...<<<<<..<<....>>...>>>>>...>>..>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<<.<<<.<<<.>>>.>>>....<<.<<<<<<.....>>>>>>>>.....>>>>>>>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.}..>>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<......>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<..<<.....<<<<....>>>>....>>...>>>>>.>>>...>>>>....>>>>>>. ((((((......((((((((((.....(((..(((((((((((((......((((((.[[..[[[)))...].((((((...(((]]..]].)))......))))))...)))....(((....)))(((((((......))))))).((..(((((.........)))))..)).))....(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...((((((((....))))))))....{.((((((((.....(((.((.(((((((((.(((...(((.(......).)))[[(...).(((.....]])))...)))...))))))))))))))..))))..)))))....((((((((..[......))))))))....}.(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((..((((..[...))))..)))).<.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))......)))))))))))))..((.(...(((.((.....((((((((((.((((...((((((......))))))...).)))...(((.(((((.......A))))))))..).))))))))).(.(((....[)))...).])).)))......).))..((((((....(((((....)))))((((((((....((((((((((......((...((((((((....))))))))..)).......)))).))))).).)))))).))..((((.((.((......)).)).))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(...)...)))))))))).))...........]]].)...))))))))))...)))))))((((((........))))))....))))))(.(((((((.((......(((((.((....))])))))...)).)))))))..).....))))))(......((....((((((.......))))))((((....(((...((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]]((((((..........(...((((....((((..(((..(((((.....((....{.....))....((..(((((..((((.((((((.((.....)).)))))).....))))..)))))...))...((.........))....)))))...)))...))))(..).....))))..)........)))))))))).))).....((......))..))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.[..).....)))))((((((....))))))(...).......(((((((((...((.........))...(((((((.....(((....))).......))))))).].(((.(((..(((((((..(((...((...(((((..((....))...)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).)))))).....)).[..(((((.....>].)))))..((((((((.(((.((......((((.((((((..(((((.(((((((((.(((.(((.))).)))....((.((((((.....)))))))).....)))))))))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..a.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}..))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((..(..)..)).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...))))))). MultiBody Refinement of 70S Ribosome from Enterococcus faecalis; 23S rRNA 6w6p B 116 2.9 RF00001 URS0000240630_474186 33004869 0003735 0005840 474186 ugugguggcgauagcgagaaggauacaccuguucccaugccgaacacagaaguuaagcuucuuagcgccgauuguagugaaggguuucccuuugugagaguaggacgucgccacgc <<<<<<<<<....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<.....<.<<<<<<<<...>>>>>>>>...>...>>..>>>>>>>>>. .((((((((....((((((((.....((((((...(.....)...))))..))....)))))).))..(........(..((((...))))..)........)...)))))))).. MultiBody Refinement of 70S Ribosome from Enterococcus faecalis; 5S rRNA 6waz C 23 4.1 RF00375 URS0000D56C30_11676 32512005 0000049 11676 guggcgcccgaacagggacuuga ....................... ....................... +1 extended HIV-1 reverse transcriptase initiation complex core (pre-translocation state); HIV-1 viral RNA genome fragment 6waz D 31 4.1 RF00005 URS0000D56C47_9606 32512005 0030533 0006412 9606 gcccggguucaagucccuguucgggcgccac <<<..>>>....................... .((()))........................ +1 extended HIV-1 reverse transcriptase initiation complex core (pre-translocation state); tRNA lysine 3 6wb0 C 35 4.2 RF00375 URS0000D56C30_11676 32512005 0000049 11676 cuagaucuagcaguggcgcccgaacagggacuuga <<<<..>>>>......................... ((((()))))......................... +3 extended HIV-1 reverse transcriptase initiation complex core (pre-translocation state); HIV-1 viral RNA genome fragment 6wb0 D 42 4.2 RF00005 URS0001A24B43_9606 32512005 0030533 0006412 9606 gcccggauguccaggguucaagucccuguucgggcgccactg <<<<<<<<>>>>.>>>>......................... (((((((()))).))))......................... +3 extended HIV-1 reverse transcriptase initiation complex core (pre-translocation state); tRNA lysine 3 6wb1 C 33 4.7 RF00375 URS0000D56C30_11676 32512005 0000049 11676 cuagcuagcaguggcgcccgaacagggacuuga <<<<>>>>......................... (((())))......................... +3 extended HIV-1 reverse transcriptase initiation complex core (intermediate state); HIV-1 viral RNA genome fragment 6wb1 D 42 4.7 RF00005 URS0001A24B43_9606 32512005 0030533 0006412 9606 gcccggauguccaggguucaagucccuguucgggcgccactg <<<<<<<..>>>.>>>>......................... (((((((..))).))))......................... +3 extended HIV-1 reverse transcriptase initiation complex core (intermediate state); tRNA lysine 3 6wb2 C 33 4.5 RF00375 URS0000D56C30_11676 32512005 0000049 11676 cuagcuagcaguggcgcccgaacagggacuuga <<<<>>>>......................... (((())))......................... +3 extended HIV-1 reverse transcriptase initiation complex core (displaced state); HIV-1 viral RNA genome fragment 6wb2 D 42 4.5 RF00005 URS0001A24B43_9606 32512005 0030533 0006412 9606 gcccggauguccaggguucaagucccuguucgggcgccactg <<<<<<<<>>>>.>>>>......................... (((((((()))).))))......................... +3 extended HIV-1 reverse transcriptase initiation complex core (displaced state); tRNA lysine 3 6wd0 3 1539 3.0 RF00177,RF01959,RF01960 URS000080DDC0_562 32612237 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<.<<....>>.>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>..<<.<<<<<......<<<<<<<<<<.......>>>>>>>>.>>.......>>>>>....>>.<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>..>>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((...(....)...))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..(......))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......(.((....)).).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((..(((((((....))))))).............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....))))))))..)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure I-A); 16S ribosomal RNA 6wd0 1 2903 3.0 RF02540,RF02541 URS0000BC4674_562 32612237 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugucgaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<<.....>>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<......<.<<<<<.<<...<<<.........>>>...>>........<<<......>>>..>>>>>.>..>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<............>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>.>........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<..<<....>>...>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<<<<<..<<.......<<<<<<<<....>>>>>>>>....>>............>>>>>...>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....(((((((..(((]]]..].)))......)))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((.......((((((((((((.(((...(((((......)))))[[......(((.....]])))...)))...))))))))))))....))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((((..)))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...).)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((((((.......)))).))...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((..(......)..)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((...(((...(((....)))...)))...)))..(((((........)))))]](((((((((((((...((((....((((..(((..(((((((((((....{{{...))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((...((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((.(...........((..(............((...(......)...))...................)..))..).)).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure I-A); 23S ribosomal RNA 6wd0 2 120 3.0 RF00001 URS00008116C5_562 32612237 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure I-A); 5S ribosomal RNA 6wd0 5 77 3.0 RF00005 URS000041AF00_562 32612237 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(((((.......)))))))))))..... Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure I-A); tRNAfMet 6wd0 6 77 3.0 RF00005 URS000041AF00_562 32612237 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((.(.........).)).(((((.......))))).....(((((.......)))))))))))..... Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure I-A); tRNAfMet 6wd0 4 18 3.0 32612237 562 aggagguaaaaauguuca .................. .................. Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure I-A); mRNA 6wd1 3 1539 3.3 RF00177,RF01959,RF01960 URS000080DDC0_562 32612237 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<.<<....>>.>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<....<<<<<<......>>>>>.>....>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<...<<<<<<.........>>>>>>.>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<.......<<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<...<<<.....>>>.>.....>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((..(...(....)...)...)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..(......))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(.(((((.((((((((((......((((((.....))))))....))))))))..))))))).)..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((..(((((((....))))))).............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....))))))))..)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((....((....))...))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure I-B); 16S ribosomal RNA 6wd1 1 2903 3.3 RF02540,RF02541 URS0000BC4674_562 32612237 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugucgaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<<.....>>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<......<.<<<<<.<<...<<<.........>>>...>>........<<<......>>>..>>>>>.>..>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<............>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<.<.<<<...<<<....>>>...>>>..>>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>.>........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<..<<....>>...>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<<<<<..<<.......<<<<<<<<....>>>>>>>>....>>............>>>>>...>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[......(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((((..)))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...).)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((((((.......)))).))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(...((......)).).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((..(......)..)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((...(((...(((....)))...)))...)))..(((((........)))))]](((((((((((((...((((....((((..(((..(((((((((((....{{{...))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((.(....).)))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((...((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.(...............(..(............((...(......)...))...................)..)......).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure I-B); 23S ribosomal RNA 6wd1 2 120 3.3 RF00001 URS00008116C5_562 32612237 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure I-B); 5S ribosomal RNA 6wd1 5 77 3.3 RF00005 URS000041AF00_562 32612237 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca ....<.<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<.........>>>>.>>........ ..((((...(((...........))).(((((.......))))).....(.((.........)).).))))...... Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure I-B); tRNAfMet 6wd1 4 18 3.3 32612237 562 aggagguaaaaauguuca .................. .................. Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure I-B); mRNA 6wd2 3 1539 3.6 RF00177,RF01959,RF01960 URS000080DDC0_562 32612237 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<.<<....>>.>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<.......<<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<..<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>....<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<...<<<.....>>>.>.....>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((............))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..(......))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(.((((..((((((((((......((((((.....))))))....))))))))..)).)))).)..(((((((((....(((((((....(((((((...((........))......)))))))....).......((....)).))))))...))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((.(((....))).)))....(....)...))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....(((..(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)...))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....(((.((.((((..((....)).)))))).)))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure II-A); 16S ribosomal RNA 6wd2 1 2903 3.6 RF02540,RF02541 URS0000BC4674_562 32612237 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugucgaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>...[.....<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<....<<<........>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))....].]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<.<...<<<.<<<<...<<<<<<<.....>>>>>.>>...>>>>.>>>..>..>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<......<.<<<<<.<<...<<<.........>>>...>>........<<<......>>>..>>>>>.>..>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<..<......>..>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>.>........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>.>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<..<<....>>...>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<<<<<..<<........<<<<<<<....>>>>>>>.....>>............>>>>>...>>>.>>>>>>>>>>>...<<<.<<<<<.......>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<...<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>......>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......((((.((((((((.(((...(((((......)))))[[......(((.....]])))...)))...)))))))).))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((((..)))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...).)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((((((.......)))).))...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(.(.........).)..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((..(......)..)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..(((((((((((....{{{...))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((.(....).)))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((...((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.(....(.........((..(............(((..((....))..)))...................)..)))....).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....((.((((.((..]]]]..)))))).)).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure II-A); 23S ribosomal RNA 6wd2 2 120 3.6 RF00001 URS00008116C5_562 32612237 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<......<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>....>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((.(((((...))))).)).......))...)))))))))). Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure II-A); 5S ribosomal RNA 6wd2 5 77 3.6 RF00005 URS000041AF00_562 32612237 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(((((.......)))))))))))..... Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure II-A); tRNAfMet 6wd2 6 77 3.6 RF00005 URS000041AF00_562 32612237 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(.(((.......))).)))))))..... Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure II-A); tRNAfMet 6wd2 4 18 3.6 32612237 562 aggagguaaaaauguuca .................. .................. Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure II-A); mRNA 6wd2 7 76 3.6 RF00005 URS00005AA258_562 32612237 0030533 0006412 562 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..))))((((((.......))))).)...(((((..]....)))))))))))).... Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure II-A); tRNAPhe 6wd3 3 1539 3.6 RF00177,RF01959,RF01960 URS000080DDC0_562 32612237 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<.<<....>>.>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<.<...<<<<<<......>>>>>.>....>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>..>>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<.....>>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((...(....)...))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..(......))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((.(((....)))....))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..(((.......((((....))))......)))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(.(((((.((((((((((......((((((.....))))))....))))))))..))))))).)..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((...((((((....))))))..............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....))))))))..)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure II-B1); 16S ribosomal RNA 6wd3 1 2903 3.6 RF02540,RF02541 URS0000BC4674_562 32612237 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugucgaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<......>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>.>..>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<.<...<<<.<<<<...<<<<<<<.....>>>>>.>>...>>>>.>>>..>..>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<.........>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<............>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>.>........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.......<<<<<<.<<....>>..>>>>>>.......>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<..<<.......<<<<<<<<....>>>>>>>>....>>............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<.......>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((.......(((.(((((.((.(((...(((((......)))))[[......(((.....]])))...)))...)).))))).)))....))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((((..)))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((.((.......)).).))...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(.(.........).)..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((..(......)..)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((...(((...(((....)))...)))...)))..(((((........)))))]](((((((((((((...((((....((((..(((..(((((((((((....{{{...))))))((..((((...(((.((((((((.((.....))))))))))...)))..[))))...))(..(.(.(....).).)...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.(..(...........((..(...(........((...(......)...)).....).............)..))..)..).)))))))))))...(((..(((((.....))))).)))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure II-B1); 23S ribosomal RNA 6wd3 2 120 3.6 RF00001 URS00008116C5_562 32612237 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<......<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>....>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((.(((((...))))).)).......))...)))))))))). Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure II-B1); 5S ribosomal RNA 6wd3 5 77 3.6 RF00005 URS000041AF00_562 32612237 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure II-B1); tRNAfMet 6wd3 6 77 3.6 RF00005 URS000041AF00_562 32612237 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure II-B1); tRNAfMet 6wd3 4 18 3.6 32612237 562 aggagguaaaaauguuca .................. .................. Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure II-B1); mRNA 6wd3 7 76 3.6 RF00005 URS00005AA258_562 32612237 0030533 0006412 562 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((........))))((((((.......))))).)...(((((.......)))))))))))).... Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure II-B1); tRNAPhe 6wd4 3 1539 3.7 RF00177,RF01959,RF01960 URS000080DDC0_562 32612237 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<.<<....>>.>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<....<<<<<<......>>>>>.>....>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<.......<<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>..>>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<.....>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<....<<<....>>>....>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((...(....)...))).)))))..)))))......(((.......((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..(......))))))).)))))))..)).)))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(.(((((.((((((((((......((((((.....))))))....))))))))..))))))).)..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...((((((....))))))..............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....(((..(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)...))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure II-B2); 16S ribosomal RNA 6wd4 1 2903 3.7 RF02540,RF02541 URS0000BC4674_562 32612237 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugucgaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<......>......>>>>>.>...[.....<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<..<<<....<<<........>>>.((......<<<.....))>>>...>>>....>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))....].]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<.<...<<<.<<<<...<<<<<<<.....>>>>>.>>...>>>>.>>>..>..>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<......<.<<<<<.<<...<<<.........>>>...>>........<<<......>>>..>>>>>.>..>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<............>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>.>........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>.>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.......<<<<<..<<....>>...>>>>>.......>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<<<<<..<<.......<<<<<<<<....>>>>>>>>....>>............>>>>>...>>>.>>>>>>>>>>>...<<<.<<<<<.......>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((.(((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[......(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((((..)))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...).)))...(((.(((((........))))))))..).))))))))).(.((.......))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((.(((.......)))..))...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(.(.........).)..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((..(......)..)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((...(((...(((....)))...)))...)))..(((((........)))))]](((((((((((((...((((....((((..(((..(((((.(((((....{{{...))))).((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((...((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((.........((((..((....))...)))).........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((((((((..((.(.(.........((..(............(((..(......)..)))...................)..))).).))..))))))))))...(((..(((((.....))))).)))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....((.((((.((..]]]]..)))))).)).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).)))))).)). Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure II-B2); 23S ribosomal RNA 6wd4 2 120 3.7 RF00001 URS00008116C5_562 32612237 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((.(((((...))))).)).......))...)))))))))). Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure II-B2); 5S ribosomal RNA 6wd4 5 77 3.7 RF00005 URS000041AF00_562 32612237 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(((((.......)))))))))))..... Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure II-B2); tRNAfMet 6wd4 6 77 3.7 RF00005 URS000041AF00_562 32612237 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(.(((..]....))).)))))))..... Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure II-B2); tRNAfMet 6wd4 4 18 3.7 32612237 562 aggagguaaaaauguuca .................. .................. Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure II-B2); mRNA 6wd4 7 76 3.7 RF00005 URS00005AA258_562 32612237 0030533 0006412 562 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..))))(((((((.....)))))).)...(((((..]....)))))))))))).... Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure II-B2); tRNAPhe 6wd5 3 1539 3.6 RF00177,RF01959,RF01960 URS000080DDC0_562 32612237 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<.<<....>>.>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<.<...<<<<<<......>>>>>.>....>>.>.....<<<....>>>....<<<<<.<.<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<.<<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<.......<<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>.>..........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((...(....)...))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..(......))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((.(...((........))......).)))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((..(((((((....))))))).............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....(((..(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)...))).....).).)))...)).)))))....))))))))..)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure II-C1); 16S ribosomal RNA 6wd5 1 2903 3.6 RF02540,RF02541 URS0000BC4674_562 32612237 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugucgaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<..<<<....<<<.<.....>>>>.((......<<<.....))>>>...>>>....>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<<.....>>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<.........>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<............>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>.>........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<..<<....>>...>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<<<<<..<<.......<<<<<<<<....>>>>>>>>....>>............>>>>>...>>>.>>>>>>>>>>>...<<<.<<<<<.......>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>.(<<...<<<<<<<...<<<<<<.......>>>>>>.....<<)..(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......((((.(((((.((.(((...(((((......)))))[[......(((.....]])))...)))...)).))))).))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((((..)))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.((.......))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((((((.......)))).))...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(.(.........).)..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((..(......)..)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((...(((...(((....)))...)))...)))..(((((........)))))]](((((((((((((...((((....((((..(((..(((((((((((....{{{...))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((.(((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((.........((((..((....))...)))).........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).).))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((.(.(..........(..(............(((..(......)..)))...................)..).).).)).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....((.((((.((..]]]]..)))))).)).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure II-C1); 23S ribosomal RNA 6wd5 2 120 3.6 RF00001 URS00008116C5_562 32612237 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure II-C1); 5S ribosomal RNA 6wd5 5 77 3.6 RF00005 URS000041AF00_562 32612237 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure II-C1); tRNAfMet 6wd5 6 77 3.6 RF00005 URS000041AF00_562 32612237 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((.(......[..).)).(((((.......))))).....(.(((..]....))).)))))))..... Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure II-C1); tRNAfMet 6wd5 4 18 3.6 32612237 562 aggagguaaaaauguuca .................. .................. Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure II-C1); mRNA 6wd5 7 76 3.6 RF00005 URS00005AA258_562 32612237 0030533 0006412 562 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..))))((((((.......))))).)...(((((..]....)))))))))))).... Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure II-C1); tRNAPhe 6wd6 3 1539 3.7 RF00177,RF01959,RF01960 URS000080DDC0_83333 32612237 0003735 0005840 83333 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<....((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<.<<....>>.>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<.......<<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..))))..<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<....<<<....>>>....>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((...(....)...))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..(......))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....(((.((((.......)))).))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((.(.(((((((((.......((((((.....)))))).....)))))))..))).)))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...((((((....)))))).....(....)...))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.(((...((....))..)))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure II-C2); 16S ribosomal RNA 6wd6 1 2903 3.7 RF02540,RF02541 URS0000BC4674_83333 32612237 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugucgaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>...[.....<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<....<<<.<.....>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))....].]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<.<...<<<.<<<<...<<<<<<<.....>>>>>.>>...>>>>.>>>..>..>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<......<.<<<<<.<<...<<<.........>>>...>>........<<<......>>>..>>>>>.>..>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<............>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>.>>........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>.>......>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<<<<<..<<.......<<<<<<<<....>>>>>>>>....>>............>>>>>...>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<.)))..>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......((((.((((((((.(((...(((((......)))))[[......(((.....]])))...)))...)))))))).))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((((..)))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...).)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((((((.......)))).))...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(.(.........).)..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((.(......).))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((...(((...(((....)))...)))...)))..(((((........)))))]](((((((((((((...((((....((((..(((..(((((.(((((....{{{...))))).((..((((...(((.((((((((.((.....))))))))))...)))..[))))...))(..(.(((....))).)...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(............(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((...((.........))...(((((((.....(((....))).......))))))).}((((.(((..((.((((..(((........(((((..((....))...)))))........)))))))...)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).)))))))....))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((..............(..(............(((..(......)..)))...................)..).....)).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..((((((((........)))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure II-C2); 23S ribosomal RNA 6wd6 2 120 3.7 RF00001 URS00008116C5_83333 32612237 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure II-C2); 5S ribosomal RNA 6wd6 5 77 3.7 RF00005 URS000041AF00_83333 32612237 0030533 0006412 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure II-C2); tRNAfMet 6wd6 6 77 3.7 RF00005 URS000041AF00_83333 32612237 0030533 0006412 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure II-C2); tRNAfMet 6wd6 4 18 3.7 32612237 562 aggagguaaaaauguuca .................. .................. Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure II-C2); mRNA 6wd6 7 76 3.7 RF00005 URS00005AA258_83333 32612237 0030533 0006412 83333 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((........)))).(((((.......))))).....(((((.......)))))))))))).... Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure II-C2); tRNAPhe 6wd7 3 1539 3.9 RF00177,RF01959,RF01960 URS000080DDC0_562 32612237 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<....((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<.<<....>>.>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<....<<<<<<......>>>>>.>....>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<.<<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<..<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>..>>>>>>>>>....<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..))))..<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<...<<<.....>>>.>.....>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((..(...(....)...)...)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..(......))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.(((((((((.......((((((.....)))))).....)))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....))))))).............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.(((...((....))..)))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure II-D); 16S ribosomal RNA 6wd7 1 2903 3.9 RF02540,RF02541 URS0000BC4674_562 32612237 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugucgaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<....<<<.<.....>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<...<<<...<<.....>>...>>>...<<....>>..<<<.......>>>......>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>...>.>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<.<...<<<.<<<<...<<<<<<<.....>>>>>.>>...>>>>.>>>..>..>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<......<.<<<<<.<<...<<<.........>>>...>>........<<<......>>>..>>>>>.>..>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<............>>>>>....>>>>>><<<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>.>>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<.<<<<<<<.<<.....>>>>>>>>>...>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>.>>........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.......<<<<<<.<<....>>..>>>>>>.......>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<..<<.......<<<<<<<<....>>>>>>>>....>>............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<.......>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<.)))..>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((.......(((.(((((.((.(((...(((((......)))))[[......(((.....]])))...)))...)).))))).)))....))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((((..)))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..(((.......))).....)))))))))))))..((.(...((((((.....(((((((.((.((((...((((((......))))))...).)))...(((.(((((........))))))))..).).))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((((((.......)))).))...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(.(.........).)..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((..(......)..)))))....))))))(.(((((...(((......(((((((......)))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((...(((...(((....)))...)))...)))..(((((........)))))]](((((((((((((...((((....((((..(((..(((((.(((((....{{{...))))).((...(((...((((((((((((.((.....))))))))))..))))..[)))....))(..(((.(....).)))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((.(((...((.........))...(((((((.....(((....))).......))))))).}((((.(((..((.((((..(((........(((((..((....))...)))))........)))))))...)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).).))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((((((((..((.(.(..........(..(............(((..(......)..)))...................)..).).).))..))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure II-D); 23S ribosomal RNA 6wd7 2 120 3.9 RF00001 URS00008116C5_562 32612237 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure II-D); 5S ribosomal RNA 6wd7 5 77 3.9 RF00005 URS000041AF00_562 32612237 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(((((.......)))))))))))..... Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure II-D); tRNAfMet 6wd7 6 77 3.9 RF00005 URS000041AF00_562 32612237 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((.(.........).)).(((((.......))))).....(((((.......)))))))))))..... Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure II-D); tRNAfMet 6wd7 4 18 3.9 32612237 562 aggagguaaaaauguuca .................. .................. Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure II-D); mRNA 6wd7 7 75 3.9 RF00005 URS00005AA258_562 32612237 0030533 0006412 562 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacc <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>... (((((((..((((........)))).(((((.......))))).....(((((.......))))))))))))... Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure II-D); tRNAPhe 6wd8 3 1539 3.7 RF00177,RF01959,RF01960 URS000080DDC0_562 32612237 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<.<<<<.<<....>>.>>>>..>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<..<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>....<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<....<<<....>>>....>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((.(...(....)...).).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((........))))......)).).....(((....)))....((((((..(......))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((((.......)))))))).....)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((.(.((((((((((......((((((.....))))))....))))))))..))).)))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))....(....)...))))).))).((.(((...((.(((.(....(((((((((....)))...(((......)))...)))))).....(((..(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)...))).....).).))....)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....(((.((.(((...((....))..))))).)))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure III-A); 16S ribosomal RNA 6wd8 1 2903 3.7 RF02540,RF02541 URS0000BC4674_562 32612237 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugucgaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<....<<<.<.....>>>>.((......<<<.....))>>>...>>>.>..>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<<.....>>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<.........>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<..<......>..>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>.>........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.......<<<<<<.<<....>>..>>>>>>.......>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<<<<<..<<.......<<<<<<<<....>>>>>>>>....>>............>>>>>...>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<.)))..>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......((((((((((.((.(((...(((((......)))))[[......(((.....]])))...)))...)).))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((((..)))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((.(......).))))...).)))...(((.(((((........))))))))..).))))))))).(.((.......))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((((((.......)))).))...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(.(.........).)..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((..(......)..)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((...(((...(((....)))...)))...)))..(((((........)))))]](((((((((((((...((((....((((..(((..(((((((((((....{{{...))))))((...(((...((((((((((((.((.....))))))))))..))))..[)))....))(..(((.(....).)))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((....(((....])))....)))...))))))(...).......(((((((((...((.........))...(((((((.....(((....))).......))))))).}((((.(((..((.((((..(((.........((((..((....))...)))).........)))))))...)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.(((.............(..(............(((..(......)..)))...................)..)....))).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....((.((((.((..]]]]..)))))).)).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure III-A); 23S ribosomal RNA 6wd8 2 120 3.7 RF00001 URS00008116C5_562 32612237 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure III-A); 5S ribosomal RNA 6wd8 5 77 3.7 RF00005 URS000041AF00_562 32612237 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(((((.......)))))))))))..... Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure III-A); tRNAfMet 6wd8 6 77 3.7 RF00005 URS000041AF00_562 32612237 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(((((.......)))))))))))..... Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure III-A); tRNAfMet 6wd8 4 18 3.7 32612237 562 aggagguaaaaauguuca .................. .................. Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure III-A); mRNA 6wd8 7 76 3.7 RF00005 URS00005AA258_562 32612237 0030533 0006412 562 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((........))))((((((.......))))).)...((.((.......)).))))))))).... Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure III-A); tRNAPhe 6wd9 3 1539 3.7 RF00177,RF01959,RF01960 URS000080DDC0_562 32612237 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<.<<....>>.>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<....<<<<<<......>>>>>.>....>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<.......<<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<..<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>....<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((...(....)...))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((........))))......)).).....(((....)))....((((((..(......))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((((.......)))))))).....)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.((((((..((((((((((......((((((.....))))))....))))))))..)).))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))....(....)...))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.(((...((....))..)))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure III-B); 16S ribosomal RNA 6wd9 1 2903 3.7 RF02540,RF02541 URS0000BC4674_562 32612237 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugucgaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu 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((((((((.......(((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......((((((((((.((.(((...(((((......)))))[[......(((.....]])))...)))...)).))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))......(.((((..(((((((..)))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...).)))...(((.(((((........))))))))..).))))))))).(.((.......))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((.((.......)).).))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((.((..(((.....{.(((((.(((..(.(.........).)..))).....(..(((......)))).)))))...)))..)).)).))...........]]].)...))))))))))...)))))))(((((..(......)..)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((...(((...(((....)))...)))...)))..(((((........)))))]](((((((((((((...((((....((((..(((..(((((((((((....{{{...))))))((...(((...((((((((((((.((.....))))))))))..))))..[)))....))(..(((.(....).)))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((...((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((.(...........(((.(............(((..(......)..)))...................).)))..).)).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....((.((((.((..]]]]..)))))).)).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure III-B); 23S ribosomal RNA 6wd9 2 120 3.7 RF00001 URS00008116C5_562 32612237 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure III-B); 5S ribosomal RNA 6wd9 5 77 3.7 RF00005 URS000041AF00_562 32612237 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(((((.......)))))))))))..... Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure III-B); tRNAfMet 6wd9 6 77 3.7 RF00005 URS000041AF00_562 32612237 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure III-B); tRNAfMet 6wd9 4 18 3.7 32612237 562 aggagguaaaaauguuca .................. .................. Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure III-B); mRNA 6wd9 7 76 3.7 RF00005 URS00005AA258_562 32612237 0030533 0006412 562 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).(((((.......))))).....(((((..]....)))))))))))).... Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure III-B); tRNAPhe 6wda 3 1539 3.8 RF00177,RF01959,RF01960 URS000080DDC0_562 32612237 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<.<<....>>.>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>..<<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>>.<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<..<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>....<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<....<<<....>>>....>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((............))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((.(....).))))......)).).....(((....)))....((((((..(......))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.((((((..(((((((((.......((((((.....)))))).....)))))))..)).))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].]((((..(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...((((((....)))))).....(....)...))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...((((((......(((..((...(((....)))...))....)))......))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...))))))).)).))..(.(..((.(.((((.(((..((((((((((((....(((.((.(((...((....))..))))).)))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure III-C); 16S ribosomal RNA 6wda 1 2903 3.8 RF02540,RF02541 URS0000BC4674_562 32612237 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugucgaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<..<<<....<<<<......>>>>.((......<<<.....))>>>...>>>....>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<...<<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>>.<<.<..<<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<<.....>>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<......<.<<<<<.<<...<<<.........>>>...>>........<<<......>>>..>>>>>.>..>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<..<......>..>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>.>........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<..<<....>>...>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<<<<<..<<.......<<<<<<<<....>>>>>>>>....>>............>>>>>...>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<.)))..>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......((((.(((((.((.(((...(((((......)))))[[......(((.....]])))...)))...)).))))).))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....((((.((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))).))))..((.(...((((((.....((((((((((.((((...((((((......))))))...).)))...(((.(((((........))))))))..).))))))))).(.((.......))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((.((.......)).).))...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(.(.........).)..))).....(...((......)).).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((..(......)..)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((...(((...(((....)))...)))...)))..(((((........)))))]](((((((((((((...((((....((((..(((..(((((((((((....{{{...))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((...((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((.........((((..((....))...)))).........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.((..(((((.(((((((((((.((.(.(..........((.(............(((..(......)..)))...................).)).).).)).)))))))))))...(((.((((((.....)))))))))....)))))..))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....((.((((.((..]]]]..)))))).)).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure III-C); 23S ribosomal RNA 6wda 2 120 3.8 RF00001 URS00008116C5_562 32612237 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure III-C); 5S ribosomal RNA 6wda 5 77 3.8 RF00005 URS000041AF00_562 32612237 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(((((.......)))))))))))..... Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure III-C); tRNAfMet 6wda 6 77 3.8 RF00005 URS000041AF00_562 32612237 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<.<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>.>>..... .((((((..((((.........)))).(((((.......))))).....(((((.......)))))))))))..... Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure III-C); tRNAfMet 6wda 4 18 3.8 32612237 562 aggagguaaaaauguuca .................. .................. Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure III-C); mRNA 6wda 7 76 3.8 RF00005 URS00005AA258_562 32612237 0030533 0006412 562 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..))))((((((.......))))).)...(((((..]....)))))))))))).... Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure III-C); tRNAPhe 6wdb 3 1539 4.0 RF00177,RF01959,RF01960 URS000080DDC0_562 32612237 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<.<<....>>.>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<....<<<<<<......>>>>>.>....>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<.<<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<.......<<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>..>>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((.((...(....)...))..)))))..)))))......(((.......((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..(......))))))).)))))))..)).)))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(.(((((.((((((((((......((((((.....))))))....))))))))..))))))).)..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....))))))).............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure IV-A); 16S ribosomal RNA 6wdb 1 2903 4.0 RF02540,RF02541 URS0000BC4674_562 32612237 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugucgaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<....<<<.<.....>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>...>.>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<<.....>>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<.........>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<............>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<.<.<<<...<<<....>>>...>>>..>>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>.>........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<..<<....>>...>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<<<<<..<<.......<<<<<<<<....>>>>>>>>....>>............>>>>>...>>>.>>>>>>>>>>>...<<<.<<<<<.......>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<.)))..>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......((((((((((.((.(((...(((((......)))))[[......(((.....]])))...)))...)).))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((((..)))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...).)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...((..((((...((.(((.......)))..))...))))..))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(.(((..(((.....{.(((((.(((..(.(.........).)..))).....(..(((......)))).)))))...)))..))).).))...........]]].)...))))))))))...)))))))(((((..(......)..)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((...(((...(((....)))...)))...)))..(((((........)))))]](((((((((((((...((((....((((..(((..(((((.(((((....{{{...))))).((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((....(((....])))....)))...))))))(...).......(((((((((...((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((.........((((..((....))...)))).........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((.(............(..(............(((..(......)..)))...................)..)...).)).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(.(((((.....(....)....))))).).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((.....((((....))))....))...))))).))).....))..).))))))))). Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure IV-A); 23S ribosomal RNA 6wdb 2 120 4.0 RF00001 URS00008116C5_562 32612237 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure IV-A); 5S ribosomal RNA 6wdb 5 77 4.0 RF00005 URS000041AF00_562 32612237 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>.>....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(((((.......)))))))))))..... Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure IV-A); tRNAfMet 6wdb 6 77 4.0 RF00005 URS000041AF00_562 32612237 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure IV-A); tRNAfMet 6wdb 4 18 4.0 32612237 562 aggagguaaaaauguuca .................. .................. Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure IV-A); mRNA 6wdb 7 73 4.0 RF00005 URS00005AA258_562 32612237 0030533 0006412 562 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>. (((((((..((((.....[..)))).(((((.......))))).....(((((..]....)))))))))))). Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure IV-A); tRNAPhe 6wdc 3 1539 4.2 RF00177,RF01959,RF01960 URS000080DDC0_562 32612237 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<.<<....>>.>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<....<<<<<<......>>>>>.>....>>.>.....<<<....>>>....<<<<<.<.<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<<<<<<<<<<.......>>>>>>>>.>>.......>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>..>>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<.....>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).].<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<...<<<.....>>>.>.....>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<....<<<....>>>....>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>.....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((..(...(....)...)...)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..(......))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(.(((((.((((((((((......((((((.....))))))....))))))))..))))))).)..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((..(((((((....))))))).............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....))))))))..)).)))))))).(...((((((......(((..((...(((....)))...))....)))......))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.(((...((....))..)))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure IV-B); 16S ribosomal RNA 6wdc 1 2903 4.2 RF02540,RF02541 URS0000BC4674_562 32612237 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugucgaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<..<<<....<<<.<.....>>>>.((......<<<.....))>>>...>>>....>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<.........>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<............>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>.>........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.......<<<<<..<<....>>...>>>>>.......>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<<<<<..<<.......<<<<<<<<....>>>>>>>>....>>............>>>>>...>>>.>>>>>>>>>>>...<<<.<<<<<.......>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<....<<<...<<<<<<<<<<.)))..>>>>>..>>>>>...>>>..>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((.......(((((((((.((.(((...(((((......)))))[[......(((.....]])))...)))...)).)))))))))....))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((((..)))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...).)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((((((.......)))).))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((..(......)..)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((...(((...(((....)))...)))...)))..(((((........)))))]](((((((((((((...((((....((((..(((..(((((((((((....{{{...))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((...((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((.........((((..((....))...)))).........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((.(............(..(............(((..(......)..)))...................)..)...).)).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(.(((((.....(....)....))))).).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((.....((((....))))....))...))))).))).....))..).))))))))). Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure IV-B); 23S ribosomal RNA 6wdc 2 120 4.2 RF00001 URS00008116C5_562 32612237 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((.(((((...))))).)).......))...)))))))))). Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure IV-B); 5S ribosomal RNA 6wdc 5 77 4.2 RF00005 URS000041AF00_562 32612237 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>.>....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(((((.......)))))))))))..... Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure IV-B); tRNAfMet 6wdc 6 77 4.2 RF00005 URS000041AF00_562 32612237 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure IV-B); tRNAfMet 6wdc 4 18 4.2 32612237 562 aggagguaaaaauguuca .................. .................. Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure IV-B); mRNA 6wdc 7 73 4.2 RF00005 URS00005AA258_562 32612237 0030533 0006412 562 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggca <<<<<<<..<<.<........>.>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>. (((((((..((((.....[..)))).(((((.......))))).....(((((..]....)))))))))))). Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure IV-B); tRNAPhe 6wdd 3 1539 3.2 RF00177,RF01959,RF01960 URS000080DDC0_562 32612237 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<.<<....>>.>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<....<<<<<<......>>>>>.>....>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<<<<<<<<<<.......>>>>>>>>.>>.......>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>..>>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<.<.<<<......>>>.....>>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<....<<<....>>>....>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((.(...(....)...).).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((.(....).))))......)).).....(((....)))....((((((..(......))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....))))))).............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((.(..((....)).).))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure V-A); 16S ribosomal RNA 6wdd 1 2903 3.2 RF02540,RF02541 URS0000BC4674_562 32612237 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugucgaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<....<<<........>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<<<<..>>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<<.....>>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<.........>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<..<......>..>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>.>........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<....<.<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.......<<<<<..<<....>>...>>>>>.......>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<<<<<..<<.......<<<<<<<<....>>>>>>>>....>>............>>>>>...>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((.......(((((((((.((.(((...(((((......)))))[[......(((.....]])))...)))...)).)))))))))....))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((((..)))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((.((.......)).).))...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(.(.........).)..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((..(......)..)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((...(((...(((....)))...)))...)))..(((((........)))))]](((((((((((((...((((....((((..(((..(((((((((((....{{{...))))))((...(((...((((((((((((.((.....))))))))))..))))..[)))....))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((((...........((..(............((...(......)...))...................)..))..)))).)))))))))))...((..((((((.....)))))).))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure V-A); 23S ribosomal RNA 6wdd 2 120 3.2 RF00001 URS00008116C5_562 32612237 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure V-A); 5S ribosomal RNA 6wdd 5 77 3.2 RF00005 URS000041AF00_562 32612237 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(((((.......)))))))))))..... Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure V-A); tRNAfMet 6wdd 6 77 3.2 RF00005 URS000041AF00_562 32612237 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure V-A); tRNAfMet 6wdd 4 18 3.2 32612237 562 aggagguaaaaauguuca .................. .................. Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure V-A); mRNA 6wdd 7 76 3.2 RF00005 URS00005AA258_562 32612237 0030533 0006412 562 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).(((((.......))))).....(((((..]....)))))))))))).... Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure V-A); tRNAPhe 6wde 3 1539 3.0 RF00177,RF01959,RF01960 URS000080DDC0_562 32612237 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<.<<....>>.>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<....<<<<<<......>>>>>.>....>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((.((...(....)...))..)))))..)))))......(((.......((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..(......))))))).)))))))..)).)))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....))))))).............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure V-B); 16S ribosomal RNA 6wde 1 2903 3.0 RF02540,RF02541 URS0000BC4674_562 32612237 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugucgaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>...[.....<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<....<<<........>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))....].]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<<..>>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<<.....>>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<......<.<<<<<.<<...<<<.........>>>...>>........<<<......>>>..>>>>>.>..>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<............>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>.>........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.......<<<<<<.<<....>>..>>>>>>.......>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<<<<<..<<.......<<<<<<<<....>>>>>>>>....>>............>>>>>...>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>.(<<...<<<<<<<...<<<<<<.......>>>>>>.....<<)..(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<.)))..>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((.......((((((((((((.(((...(((((......)))))[[......(((.....]])))...)))...))))))))))))....))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((((..)))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((((((.......)))).))...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(.(.........).)..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((..(......)..)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((...(((...(((....)))...)))...)))..(((((........)))))]](((((((((((((...((((....((((..(((..(((((((((((....{{{...))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((.(....).)))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((.(...........((..(...(........(((..(......)..))).....).............)..))..).)).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure V-B); 23S ribosomal RNA 6wde 2 120 3.0 RF00001 URS00008116C5_562 32612237 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure V-B); 5S ribosomal RNA 6wde 5 77 3.0 RF00005 URS000041AF00_562 32612237 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(((((.......)))))))))))..... Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure V-B); tRNAfMet 6wde 6 77 3.0 RF00005 URS000041AF00_562 32612237 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(((((.......)))))))))))..... Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure V-B); tRNAfMet 6wde 4 18 3.0 32612237 83333 aggagguaaaaauguuca .................. .................. Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure V-B); mRNA 6wde 7 76 3.0 RF00005 URS0000099A18_562 32612237 0030533 0006412 562 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..))))((((((.......))))).)...(((((..]....)))))))))))).... Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure V-B); tRNAPhe 6wdf 3 1539 3.3 RF00177,RF01959,RF01960 URS000080DDC0_83333 32612237 0003735 0005840 83333 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<.<<....>>.>>>>.>>>>>..>>>>>......<<..<....<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>>>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>..<<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>>.<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>..>>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>.>..........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<...<<<.....>>>.>.....>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<....<<<....>>>....>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((...(....)...))).)))))..)))))......(((.......((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..(......))))))).)))))))..)).)))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....))))))).............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.(((...((....))..)))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure VI-A); 16S ribosomal RNA 6wdf 1 2903 3.3 RF02540,RF02541 URS0000BC4674_83333 32612237 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugucgaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<....<<<.<.....>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<<.....>>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<.........>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<............>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>.>........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<..<<....>>...>>>>>........>>>>>>>>..>>>>>.<<<<<.......>>>>>.........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<<<<<..<<.......<<<<<<<<....>>>>>>>>....>>............>>>>>...>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((.......(((((((((.((.(((...(((((......)))))[[......(((.....]])))...)))...)).)))))))))....))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((((..)))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...).)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((.(((.......)))..))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(.(.........).)..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((..(......)..)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((...(((...(((....)))...)))...)))..(((((........)))))]](((((((((((((...((((....((((..(((..(((((.(((((....{{{...))))).((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((.(....).)))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((...((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((.(...........((..(............(((..(......)..)))...................)..))..).)).)))))))))))...(((..(((((.....))))).)))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure VI-A); 23S ribosomal RNA 6wdf 2 120 3.3 RF00001 URS00008116C5_83333 32612237 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((.(.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...).)))))))). Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure VI-A); 5S ribosomal RNA 6wdf 5 77 3.3 RF00005 URS000041AF00_83333 32612237 0030533 0006412 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<...<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>.>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure VI-A); tRNAfMet 6wdf 4 18 3.3 32612237 83333 aggagguaaaaauguuca .................. .................. Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure VI-A); mRNA 6wdf 7 76 3.3 RF00005 URS00005AA258_83333 32612237 0030533 0006412 83333 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca .<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((........)))).(((((.......))))).....((.((.......)).))))))))..... Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure VI-A); tRNAPhe 6wdg 3 1539 3.3 RF00177,RF01959,RF01960 URS000080DDC0_83333 32612237 0003735 0005840 83333 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<.<<....>>.>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>..<<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>>.<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>..>>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<..<<<<<<....<...<<<.....>>>.>.....>>>>>>.....<<<<<.....>>>>>.........>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((...(....)...))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..(......))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......(.((....)).).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((..(((((((....))))))).............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....))))))))..)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.(((...((....))..)))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure VI-B); 16S ribosomal RNA 6wdg 1 2903 3.3 RF02540,RF02541 URS0000BC4674_83333 32612237 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugucgaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<....<<<.<.....>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<<.....>>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<......<.<<<<<.<<...<<<.........>>>...>>........<<<......>>>..>>>>>.>..>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<............>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>.>........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<..<<....>>...>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<<<<<..<<.......<<<<<<<<....>>>>>>>>....>>............>>>>>...>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<.)))..>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((.......(((((((((.((.(((...(((((......)))))[[......(((.....]])))...)))...)).)))))))))....))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((((..)))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...).)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(.((((.......))))..)...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(.(.........).)..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((..(......)..)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((...(((...(((....)))...)))...)))..(((((........)))))]](((((((((((((...((((....((((..(((..(((((.(((((....{{{...))))).((...(((...((((((((((((.((.....))))))))))..))))..[)))....))(..(((.(....).)))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((...((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((.(...........((..(............(((..(......)..)))...................)..))..).)).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure VI-B); 23S ribosomal RNA 6wdg 2 120 3.3 RF00001 URS00008116C5_83333 32612237 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((.(.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...).)))))))). Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure VI-B); 5S ribosomal RNA 6wdg 5 77 3.3 RF00005 URS000041AF00_83333 32612237 0030533 0006412 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<.<<<...<<<<.........>>>>.<<<<<.......>>>>.>.....<<<.........>>>..>>>.>..... .(.((((..((((.........)))).(((((.......))))).....(.((.........)).))))).)..... Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure VI-B); tRNAfMet 6wdg 4 18 3.3 32612237 83333 aggagguaaaaauguuca .................. .................. Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure VI-B); mRNA 6wdg 7 76 3.3 RF00005 URS00005AA258_83333 32612237 0030533 0006412 83333 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca .<<<<<<..<<<<........>>>><<<<<<<.....>>>>>>.>...<<<<<.......>>>>>>>>>>>..... .((((((..((((.....[..)))).(((((.......))))).....(((((..]....)))))))))))..... Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure VI-B); tRNAPhe 6wdh 3 1539 4.3 RF00177,RF01959,RF01960 URS000080DDC0_562 32612237 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<.<<....>>.>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<....<<<<<<......>>>>>.>....>>.>.....<<<....>>>....<<<<<.<.<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<...<<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<<<<<<<<<<.......>>>>>>>>.>>.......>>>>>....>..<<<<<(((...<<<<<........))).........>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>.>..........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<.....>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<...<<<.....>>>.>.....>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<....<<<....>>>....>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>......<<<<<<<<....>>>>>>>>............. .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((.((...(....)...))..)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..(......))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(.(((((.((((((((((......((((((.....))))))....))))))))..))))))).)..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((..(((((((....))))))).............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....))))))))..)).)))))))).(...((((((......(((..((...(((....)))...))....)))......))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.(((...((....))..)))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Non-cognate Structure IV-B1); 16S ribosomal RNA 6wdh 1 2903 4.3 RF02540,RF02541 URS0000BC4674_562 32612237 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugucgaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<..<<<....<<<.<.....>>>>.((......<<<.....))>>>...>>>....>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>...>.>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<.<...<<<.<<<<...<<<<<<<.....>>>>>.>>...>>>>.>>>..>..>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<......<.<<<<<.<<...<<<.........>>>...>>........<<<......>>>..>>>>>.>..>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<............>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<.<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>....>>.>........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<..<<<..<<<<<<<..<<<........<<<<<..<<....>>...>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<<<<<..<<.......<<<<<<<<....>>>>>>>>....>>............>>>>>...>>>.>>>>>>>>>>>...<<<.<<<<<.......>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>.(<<...<<<<<<<...<<<<<<.......>>>>>>.....<<)..(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<.)))..>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((.......((((((((((((.(((...(((((......)))))[[......(((.....]])))...)))...))))))))))))....))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((((..)))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...).)))...(((.(((((........))))))))..).))))))))).(.((.......))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((.((.......)).).))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(...((......)).).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((.((..(......)..)).))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((...(((...(((....)))...)))...)))..(((((........)))))]](((((((((((((...((((....((((..(((..(((((.(((((....{{{...))))).((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((...((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((((((((..(..(............(..(............(((..(......)..)))...................)..)...)..)..))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((.....((((....))))....))...))))).))).....))..).))))))))). Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Non-cognate Structure IV-B1); 23S ribosomal RNA 6wdh 2 120 4.3 RF00001 URS00008116C5_562 32612237 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<........<<<<<<<...>>>>>>>........>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((.(((((...))))).)).......))...)))))))))). Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Non-cognate Structure IV-B1); 5S ribosomal RNA 6wdh 5 77 4.3 RF00005 URS000041AF00_562 32612237 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>.>....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(((((.......)))))))))))..... Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Non-cognate Structure IV-B1); tRNAfMet 6wdh 6 77 4.3 RF00005 URS000041AF00_562 32612237 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((.(......[..).)).(((((.......))))).....(((((..]....)))))))))))..... Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Non-cognate Structure IV-B1); tRNAfMet 6wdh 4 18 4.3 32612237 562 aggagguaaaaaugcuca .................. .................. Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Non-cognate Structure IV-B1); mRNA 6wdh 7 73 4.3 RF00005 URS00005AA258_562 32612237 0030533 0006412 562 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggca <<<<<<...<<<<........>>>><<<<<<.......>>>>>.>...<<<<<.......>>>>>.>>>>>>. (((((((..((((.....[..))))((((((.......))))).)...(((((..]....)))))))))))). Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Non-cognate Structure IV-B1); tRNAPhe 6wdi 3 1539 4.0 RF00177,RF01959,RF01960 URS000080DDC0_562 32612237 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<....((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<.<<....>>.>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<....<<<<<<......>>>>>.>....>>.>.....<<<....>>>....<<<<<.<.<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<.<<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<<<<<<<<<<.......>>>>>>>>.>>.......>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..))))..<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<..<<<<<<....<...<<<.....>>>.>.....>>>>>>.....<<<<<.....>>>>>.........>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<....<<<....>>>....>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((.((...(....)...))..)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..(......))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....))))))).............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...((((((......(((..((...(((....)))...))....)))......))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.(((...((....))..)))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Non-cognate Structure IV-B2); 16S ribosomal RNA 6wdi 1 2903 4.0 RF02540,RF02541 URS0000BC4674_562 32612237 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugucgaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<..<<<....<<<.<.....>>>>.((......<<<.....))>>>...>>>....>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>...>.>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<......<<...<<<.<<<<...<<<<<<<.....>>>>>.>>...>>>>.>>>..>>.......>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<......<.<<<<<.<<...<<<.........>>>...>>........<<<......>>>..>>>>>.>..>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<............>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>.>........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.......<<<<<..<<....>>...>>>>>.......>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<<<<<..<<.......<<<<<<<<....>>>>>>>>....>>............>>>>>...>>>.>>>>>>>>>>>...<<<.<<<<<.......>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<.)))..>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((.......(((((((((.((.(((...(((.(......).)))[[......(((.....]])))...)))...)).)))))))))....))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((((..)))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...).)))...(((.(((((........))))))))..).))))))))).(.((.......))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((.((.......)).).))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(.(((..(((.....{.(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))).).))...........]]].)...))))))))))...)))))))(((((..(......)..)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((...(((...(((....)))...)))...)))..(((((........)))))]](((((((((((((...((((....((((..(((..(((((((((((....{{{...))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((....(((....])))....)))...))))))(...).......(((((((((...((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((((((((..(..(............(..(............(((..(......)..)))...................)..)...)..)..))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....((.((((.((..]]]]..)))))).)).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..((((((((........)))))..))).(((((.....))))).....)))))..)...))..).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((.....((((....))))....))...))))).))).....))..).))))))))). Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Non-cognate Structure IV-B2); 23S ribosomal RNA 6wdi 2 120 4.0 RF00001 URS00008116C5_562 32612237 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<........<<<<<<<...>>>>>>>........>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((.(((((...))))).)).......))...)))))))))). Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Non-cognate Structure IV-B2); 5S ribosomal RNA 6wdi 5 77 4.0 RF00005 URS000041AF00_562 32612237 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>.>....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Non-cognate Structure IV-B2); tRNAfMet 6wdi 6 77 4.0 RF00005 URS000041AF00_562 32612237 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Non-cognate Structure IV-B2); tRNAfMet 6wdi 4 18 4.0 32612237 562 aggagguaaaaaugcuca .................. .................. Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Non-cognate Structure IV-B2); mRNA 6wdi 7 73 4.0 RF00005 URS00005AA258_562 32612237 0030533 0006412 562 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggca <<<<<<<..<<<<........>>>><<<<<<<.....>>>>>>.>...<<<<<.......>>>>>>>>>>>>. (((((((..((((........))))((((((.......))))).)...(((((.......)))))))))))). Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Non-cognate Structure IV-B2); tRNAPhe 6wdj 3 1539 3.7 RF00177,RF01959,RF01960 URS000080DDC0_83333 32612237 0003735 0005840 83333 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<.<<....>>.>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<.<...<<<<<<......>>>>>.>....>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<.<<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>..<<.<<<<<.......<<<<<<<<<.......>>>>>>>>.>........>>>>>....>>.<<<<<(((...<<<<<........))).........>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>..>>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((.(...(....)...).).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((........))))......)).).....(((....)))....((((((..(......))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..(((.......((((....))))......)))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((..(((((((....))))))).............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....))))))))..)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((...(((((((((((....((((((.((((..((....)).))))))))))...)))))))))))...))).))))..).))...)..)..(((((((((....)))))))))}........... Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Non-cognate Structure V-A1); 16S ribosomal RNA 6wdj 1 2903 3.7 RF02540,RF02541 URS0000BC4674_83333 32612237 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugucgaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>...>.>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<......<<...<<<.<<<<...<<<<<<<.....>>>>>.>>...>>>>.>>>..>>.......>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<......<.<<<<<.<<...<<<.........>>>...>>........<<<......>>>..>>>>>.>..>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<............>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>....>>>>........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<<.<<....>>..>>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>...>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<...<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>......>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<.........>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[......(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((((..)))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...).)))...(((.(((((........))))))))..).))))))))).(.((.......))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((((((.......)))).))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(.(.........).)..))).....(...((......)).).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((..(......)..)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((...(((...(((....)))...)))...)))..(((((........)))))]](((((((((((((...((((....((((..(((..(((((((((((....{{{...))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((.(....).)))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((...((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((.(...........((..(............(((..(......)..)))...................)..))..).)).)))))))))))...(((..(((((.....))))).)))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Non-cognate Structure V-A1); 23S ribosomal RNA 6wdj 2 120 3.7 RF00001 URS00008116C5_83333 32612237 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((.............))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Non-cognate Structure V-A1); 5S ribosomal RNA 6wdj 5 77 3.7 RF00005 URS000041AF00_83333 32612237 0030533 0006412 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(((((.......)))))))))))..... Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Non-cognate Structure V-A1); tRNAfMet 6wdj 6 77 3.7 RF00005 URS000041AF00_83333 32612237 0030533 0006412 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Non-cognate Structure V-A1); tRNAfMet 6wdj 4 18 3.7 32612237 83333 aggagguaaaaaugcuca .................. .................. Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Non-cognate Structure V-A1); mRNA 6wdj 7 76 3.7 RF00005 URS00005AA258_83333 32612237 0030533 0006412 83333 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..))))((((((.......))))).)...(((((..]....)))))))))))).... Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Non-cognate Structure V-A1); tRNAPhe 6wdk 3 1539 3.6 RF00177,RF01959,RF01960 URS000080DDC0_562 32612237 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<.<<....>>.>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<.<...<<<<<<......>>>>>.>....>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<.<<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>..<<.<<<<<.......<<<<<<<<<.......>>>>>>>>.>........>>>>>....>>.<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<.....>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<...<<<.....>>>.>.....>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((..(...(....)...)...)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..(......))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....))))))).............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.(((...((....))..)))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Non-cognate Structure V-A2); 16S ribosomal RNA 6wdk 1 2903 3.6 RF02540,RF02541 URS0000BC4674_562 32612237 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugucgaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>...[.....<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<....<<<.<.....>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))....].]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>...>.>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<<.....>>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<......<.<<<<<.<<...<<<.........>>>...>>........<<<......>>>..>>>>>.>..>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<............>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>.>>........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<..<<....>>...>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>...>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<.)))..>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<.........>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. (.((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((.(......).)))[[......(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((((..)))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...).)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((((((.......)))).))...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(.(.........).)..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((..(......)..)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((...(((...(((....)))...)))...)))..(((((........)))))]](((((((((((((...((((....((((..(((..(((((((((((....{{{...))))))((...(((...((((((((((((.((.....))))))))))..))))..[)))....))(...((((....))))....))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((......((....(((....])))....))....))))))(...).......(((((.(((...((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).).))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.(..(.(.........(((.(............(((..(......)..)))...................).)))).)..).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))).). Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Non-cognate Structure V-A2); 23S ribosomal RNA 6wdk 2 120 3.6 RF00001 URS00008116C5_562 32612237 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.....<.<<<<<<<<...>>>>>>>>...>...>>...>>>>>>>>>>. (.((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))).). Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Non-cognate Structure V-A2); 5S ribosomal RNA 6wdk 5 77 3.6 RF00005 URS000041AF00_562 32612237 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Non-cognate Structure V-A2); tRNAfMet 6wdk 6 77 3.6 RF00005 URS000041AF00_562 32612237 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Non-cognate Structure V-A2); tRNAfMet 6wdk 4 18 3.6 32612237 562 aggagguaaaaaugcuca .................. .................. Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Non-cognate Structure V-A2); mRNA 6wdk 7 76 3.6 RF00005 URS00005AA258_562 32612237 0030533 0006412 562 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).(((((.......))))).....(((((..]....)))))))))))).... Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Non-cognate Structure V-A2); tRNAPhe 6wdl 3 1539 3.7 RF00177,RF01959,RF01960 URS000080DDC0_83333 32612237 0003735 0005840 83333 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<.<<....>>.>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<....<<<<<<......>>>>>.>....>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>..<<.<<<<<.......<<<<<<<<<.......>>>>>>>>.>........>>>>>....>>.<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<...<<<.....>>>.>.....>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((...(....)...))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..(......))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((..(((((((....))))))).............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....))))))))..)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Non-cognate Structure V-B1); 16S ribosomal RNA 6wdl 1 2903 3.7 RF02540,RF02541 URS0000BC4674_83333 32612237 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugucgaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<....<<<.<.....>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>...>.>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<<.....>>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<......<.<<<<<.<<...<<<.........>>>...>>........<<<......>>>..>>>>>.>..>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<............>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>.>........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<..<<....>>...>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<<<<<..<<.......<<<<<<<<....>>>>>>>>....>>............>>>>>...>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<.)))..>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((.(((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((.......((((((((((((.(((....((((......)))).[[......(((.....]])))...)))...))))))))))))....))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((((..)))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...).)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((((((.......)))).))...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(.(.........).)..))).....(...((......)).).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((..(......)..)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..(((((((((((....{{{...))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((.(((...((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).).))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((.(.(..........(..(............(((..(......)..)))...................)..).).).)).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).)))))).)). Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Non-cognate Structure V-B1); 23S ribosomal RNA 6wdl 2 120 3.7 RF00001 URS00008116C5_83333 32612237 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<........<<<<<<<...>>>>>>>........>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Non-cognate Structure V-B1); 5S ribosomal RNA 6wdl 5 77 3.7 RF00005 URS000041AF00_83333 32612237 0030533 0006412 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(((((.......)))))))))))..... Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Non-cognate Structure V-B1); tRNAfMet 6wdl 6 77 3.7 RF00005 URS000041AF00_83333 32612237 0030533 0006412 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(((((.......)))))))))))..... Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Non-cognate Structure V-B1); tRNAfMet 6wdl 4 18 3.7 32612237 83333 aggagguaaaaaugcuca .................. .................. Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Non-cognate Structure V-B1); mRNA 6wdl 7 76 3.7 RF00005 URS00005AA258_83333 32612237 0030533 0006412 83333 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..))))((((((.......))))).)...(((((..]....)))))))))))).... Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Non-cognate Structure V-B1); tRNAPhe 6wdm 3 1539 3.6 RF00177,RF01959,RF01960 URS000080DDC0_562 32612237 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<.<<....>>.>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<.<...<<<<<<......>>>>>.>....>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>..<<.<<<<<.......<<<<<<<<<.......>>>>>>>>.>........>>>>>....>>.<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<.....>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((.((...(....)...))..)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..(......))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....))))))).............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((...(((((((((((....((((((.((((..((....)).))))))))))...)))))))))))...))).))))..).))...)..)..(((((((((....)))))))))}........... Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Non-cognate Structure V-B2); 16S ribosomal RNA 6wdm 1 2903 3.6 RF02540,RF02541 URS0000BC4674_562 32612237 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugucgaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>...[.....<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<....<<<.<.....>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))....].]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>...>.>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<<.....>>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<......<.<<<<<.<<...<<<.........>>>...>>........<<<......>>>..>>>>>.>..>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<............>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<.<.<<<...<<<....>>>...>>>..>>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>....>>>>........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>.>......>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<<<<<..<<.......<<<<<<<<....>>>>>>>>....>>............>>>>>...>>>.>>>>>>>>>>>...<<<.<<<<<.......>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>.(<<...<<<<<<<...<<<<<<.......>>>>>>.....<<)..(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((.......(((.((((((((.(((....((((......)))).[[......(((.....]])))...)))...)))))))).)))....))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((((..)))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...).)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((((((.......)))).))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(.(.........).)..))).....(...((......)).).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((..(......)..)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((...(((...(((....)))...)))...)))..(((((........)))))]](((((((((((((...((((....((((..(((..(((((((((((....{{{...))))))((...(((...((((((((((((.((.....))))))))))..))))..[)))....))(..(((.(....).)))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((...((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((.(.(..........(..(............(((..(......)..)))...................)..).).).)).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((.(((..(((((((((......))))))..))).(((((.....))))).....))).)..)...))..).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Non-cognate Structure V-B2); 23S ribosomal RNA 6wdm 2 120 3.6 RF00001 URS00008116C5_562 32612237 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<........<<<<<<<...>>>>>>>........>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Non-cognate Structure V-B2); 5S ribosomal RNA 6wdm 5 77 3.6 RF00005 URS000041AF00_562 32612237 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Non-cognate Structure V-B2); tRNAfMet 6wdm 6 77 3.6 RF00005 URS000041AF00_562 32612237 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(((((.......)))))))))))..... Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Non-cognate Structure V-B2); tRNAfMet 6wdm 4 18 3.6 32612237 562 aggagguaaaaaugcuca .................. .................. Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Non-cognate Structure V-B2); mRNA 6wdm 7 76 3.6 RF00005 URS0000099A18_562 32612237 0030533 0006412 562 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..))))((((((.......))))).)...(((((..]....)))))))))))).... Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Non-cognate Structure V-B2); tRNAPhe 6wnv 3 1539 3.5 RF00177,RF01959,RF01960 URS000080DDC0_562 32518240 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<.<<<<........>>>>..>>>>>..>>>>>......<<..<....<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..........>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>>>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<........<<<<<<<<.......>>>>>>>>..........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>.>..........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<.......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>.............>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>....>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<..<.<<<<<<<........>>>>>>>>...>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((..(.(........).)...)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..(......))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..(((.......((((....))))......)))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((....(((((.(....(((((((...((........))......)))))))....).......((....))..)))))...))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....))))))).............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(.(((((.....(((..((...(((....)))...))....))).....))))).)......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... 70S ribosome without free 5S rRNA and with a perturbed PTC; 16S ribosomal RNA 6wnv 4 3025 3.5 RF02540,RF02541,RF00001 URS0001A24B42_562 32518240 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugucgaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggcugcuccccaugcgagaguagggaacugccaggcauucggugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguagugugggguaaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggaucugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<......<<<<<<<<<<<<<.<<<....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>>.>>...............<<....>>....>>.........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<....<.<<<<.....>>>>..>....>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<.............<<<<<<<<..<....<<...<<<<<<<<<<<...>>>>>>>>>>>.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.>>.....>.>>>>>>>>.....<<..<<<<<..<<........<<<<<.<<...<<<.........>>>...>>.........<<......>>...>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<.<<....>>.>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....[[[...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>.>........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<<.<<....>>..>>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.<<.....<<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<.<<..............<<...........<<..<<<......>>>..>>..................>>.....>>>..>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.[[[.>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>>....<<<<<<<<<...<<.......>>...>>>>>>>>>.....]]]....<<.<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>..>>...<<<<<<<....>>>.>>>>....>>..>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]].>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((.(((.(((...(((((......)))))[[......(((.....]])))...)))...))).)))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...).)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((..(((.....)))...))...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.......((((((((.......((...((((((((((.....)))))))))).....((((((((....(((((((...(.....)...))))..)))...)))))).)).)).......)))))))).....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(...((......)).).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((.(......).))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((...((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((((.(((..................(..(............(....(......)....)...................)..).........))).))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((...{{.[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(.((((((...((.......))...)))))).)......}}.......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). 70S ribosome without free 5S rRNA and with a perturbed PTC; 23s-5s joint ribosomal RNA 6wnw 3 1539 3.2 RF00177,RF01959,RF01960 URS000080DDC0_562 32518240 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<.<<<<........>>>>..>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<......>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>.....<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>.......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>.>..........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((..(............)...)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((.(....).))))......)).).....(((....)))....((((((..(......))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..(((.......((((....))))......)))..((.(((((...(..(.(((.((((.......)))).))).)...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((.((((((.....)))))).)))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...((((((....))))))..............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Active 70S ribosome without free 5S rRNA and bound with A- and P- tRNA; 16S ribosomal RNA 6wnw 4 3031 3.2 RF02540,RF02541,RF00001 URS0001A24B42_562 32518240 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugucgaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggcugcuccccaugcgagaguagggaacugccaggcauucggugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguagugugggguaaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu 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Active 70S ribosome without free 5S rRNA and bound with A- and P- tRNA; 23s-5s joint ribosomal RNA 6wnw 5 77 3.2 RF00005 URS000041AF00_562 32518240 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Active 70S ribosome without free 5S rRNA and bound with A- and P- tRNA; tRNAfMet 6wnw 1 10 3.2 32518240 562 aaaauguuca .......... .......... Active 70S ribosome without free 5S rRNA and bound with A- and P- tRNA; mRNA 6wnw 7 76 3.2 RF00005 URS00005AA258_562 32518240 0030533 0006412 562 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).(((((.......))))).....(((((..]....)))))))))))).... Active 70S ribosome without free 5S rRNA and bound with A- and P- tRNA; tRNAPhe 6woo 5 3271 2.9 RF02540,RF02543 URS00021ED8E5_4932 33024099 0003735 0005840 4932 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..........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..<<<...<.......<<.<<<<<<...>>>>>>.>>.......>.....<<<<<<<.<<<<<<<<<<<<<<<<<<<<.....<<<<......>>>>.(.......<<<......)>>>....>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<....<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<<..>>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<..<<.<<<<.....>>>>.>>>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<......<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>....>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<<<<<<<<<<<<..[[[..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<<....>>>>>>>>>>>>.>.>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<.<<<<<<<<<<<...........<<..<<<<.....<<<..>>>.....>>>>..>>..........................>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<..<..<<<.....<<<<....>>>>.....>>>>.>>>..>>>>>.<<<<<.......>>>>>.........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<..<<<<<<......<<<<...........<<<..<.<<....>>............>.>>>..>>>>.......>>>>>>...<<<<<.....<<<<................................<<.<<.......>>.>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))......<<<<<<<..<<<<.))))))>>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<<]]].>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ..........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.((((((((.((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..)))).)))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.(((((....(((((((((((((((.(((((((.......(((((((......((((((....)))))).......))))))).....))))).)).)))))))........(((....)))....)))))))).....))))).))))).[((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((((((((((....((.(((((((.....(((....(((..(.(((.....((..(.....)..))...))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.......(.(((..((...((.........))...))......(...((......)).).))).)...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((..(((((((...((.....)).))))))....[[(((.((...((....(((....)))........((((((........))))))....))....))...(((((........)))))]]((((..(((((.(...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....).))..))).)))).))).))).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((...........((..((.(.....(.(().)).....).))..))..........................)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...(......((((....))))......).)))))..))))).((((.........)))).........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..((((((.((...(.((...........(((.(..((....)).............))))..)).)....)).))))))....((((.....((((..(...(......)...)...........>...(.(.(......))..)..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.............))))...)))).))))....)))))))).......((((((...(.((....((.(........(((((((..).)))))).....))).......((((((...(((((....(((......)))....))))).)))))).............)).)...))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. CryoEM structure of yeast 80S ribosome with Met-tRNAiMet, eIF5B, and GDP; 25S ribosomal RNA 6woo 7 121 2.9 RF00001 URS000055688D_4932 33024099 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). CryoEM structure of yeast 80S ribosome with Met-tRNAiMet, eIF5B, and GDP; 5S ribosomal RNA 6woo 8 157 2.9 RF00002 URS00004A45D3_4932 33024099 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>.................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....))))))))).................... CryoEM structure of yeast 80S ribosome with Met-tRNAiMet, eIF5B, and GDP; 5.8S ribosomal rRNA 6woo 2 1780 2.9 RF01960,RF01959,RF00177 URS00021ED952_4932 33024099 0003735 0005840 4932 aucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucgauuuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucau ..<<<<<.{.[[[[>>>>><<<<.<<<<<<...<.<...<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<..<<..<<....<<<................<<......<<.<<<.....>>>.>>......>>........<<<<<............>>>>><...<<<<<<......((((((..<<<....>>>....<<......>>>>>>>>.....>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>..>>>..>....>.>.....<<<<<<<<<..<......>..>>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>>.........<<<[[.....<.<<...<<<........<<<<<.<<<<.....<..>.....>>>>.>>>>>......<<<<.....<<....<<.......>>....>>.....>>>>....<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........<<<..<<<<<<<<......)))))).>>>>>>>>.>>>...........<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<.....<...<<<<.<.....>.>>>>...>..>>>>>..........<<<.<<..<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>....<<..]]>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..]]]].}<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<......<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<<<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>...>.>>>>>>>.......>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<............................>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>....... ..((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...))[))......(((.......(((..((..((....(((............[...((......((.(((.....))).))......))........(((((...(....)...)))))(.(.((((((......{.{{{.{.(((....))).....(......).)))))).)...).(]((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)....).).....((.((((((.(((....))).))))))..))......(.(.(...........))..).........(((.([[....(.((((.....((..]])).......)))))).)))..))))))))))..[......((([[...(.(.((...(((.........(.((.(((.......().......))).))..)......((((..........(((.......)))..........))).)....((((.((.......((..((.......)).(((.....)))....))......)).))..))..........(((..(.(.((((......}}}}.}.))).).)).)))...........((..((..(...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)..))...))...)))...)).)....(((((.........((((.........))))......)))))......{...(((.((.(((...(((((((.(((........))))))))))...)).)..((..]]))...))...].))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........((((..(....(((((........((.(.(........).).))......)))))...((.(((...(.((((((.(..(((.(.(((....)))..(.((......)))....).)))....(((((.((..((((..(((((..(((((....)))))....)))))..)))).))..(.(((((.......)))))....)..))))).)..))).))).....).))))).....)..))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...((.((............................)).))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}...... CryoEM structure of yeast 80S ribosome with Met-tRNAiMet, eIF5B, and GDP; 18S ribosomal RNA 6woo 3 76 2.9 RF00005 URS00021ED90D_4932 33024099 0030533 0006412 4932 agcgccguggcgcagugggaagcgcgcagggcucauaacccugauguccucggaucgaaaccgagcggcgcuacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((........)))).(((((.......))))).....(((((.......)))))))))))).... CryoEM structure of yeast 80S ribosome with Met-tRNAiMet, eIF5B, and GDP; Met-tRNA-iMet 6wqn 1 2687 2.9 RF02540,RF02541,RF00002 URS0001A24B6A_1280 32566908 0003735 0005840 1280 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.<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<<......<<<<<<.[...((.>>>.....<<<<<<<..<<<))...].>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<<<<<<<...........>>>>>>.>>.>>....<<<<<......<......>.......>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..<<<....<<......>>.......<<<.......<........<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>.>.>..........>>>......<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..>>>......>>.>>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<..<<<<......>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<.<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>.>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<........>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<...<<<<<<<<<......<<...<<<<<<<..........>>>>>>>..>>.......>>>>.>>>>>..>>>>>>>.>>..<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<.<<........>>.>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<.....>>>>>>....>>>>>><.<<<<<<<.<.......<<<<<.<<....>>.>>>>>....>.>>>>>>>..>.....>>>>>><......<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<........<<...<<<<....<<<<...<<...<......<<<.........>>>...<.....<<<...<<.........>>...>>>......>...................>....>>...>>>>.........>>>.>.>>.......>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<....>.>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<.<<<<....>>>>.>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<..<<...<<<<<........>>>>>...>>..>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<......>>>>....<<.<<<<<<.....>>>>>>>>.....>>>>>>>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<......<<<.......>>>........<<.[.(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]......<<<<<<.<<<..>>>>..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<......>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>.<<<....>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>... 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Structure of the 50S subunit of the ribosome from Methicillin Resistant Staphylococcus aureus in complex with the antibiotic, contezolid; 23S rRNA 6wqn 2 111 2.9 RF00001 URS0001A24B3E_1280 32566908 0003735 0005840 1280 cuggugacuauagcaaggaggucacaccuguucccaugccgaacacagaaguuaagcuccuuagcgacgaugguaguccaacuuacguuccgcuagaguagaacguuccag ..<<........<<<<.<<<.....<<<<<...............>>>..>>....>>>.>>.>>.....<..<.<..............>...>.>.........>>... ............((((..((.......((.(...(.....)...).))........))..)).))..........(..............).................... Structure of the 50S subunit of the ribosome from Methicillin Resistant Staphylococcus aureus in complex with the antibiotic, contezolid; 5S rRNA 6wqq 1 2698 3.1 RF02540,RF02541,RF00002 URS0001A24B6A_1280 32566908 0003735 0005840 1280 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.((((......((((((((((.....(((..((((((((.((((......((((((.[[..[[[)))...].((((((...(((]]..]].)))......))))))...)))....(((....)))(((((((......))))))).(((((.((...........)).))).)).))....(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((([...((((()))))....(.((((.((.............(..((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))))...).......))...))))]....(((((((...[.......)))))))....).(((((].[[[[)))))..)))......))..)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((..((((..[...))))..)))).{.(.(........).).((((((....(((((((.(((((..(((...(((.....)))...)))...((....))...(((.....)))......))))).)))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...){)))...(((.(((((.......A))))))))..).))))))))).(.(((....[)))...).]))))))......).))..((((((....(((((....)))))(((((((((...((.((((((.....(((...((((((((........))))))))..)).).....)))).)).))..))))))).))..((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((.((.(...<....).)).)))).))...........]]].)...))))))))))...)))))))((((((.....))))))....))))))(.(((((((.((......(((((.((....))])))))...)).)))))))..).....))))))(......((....((((((.......))))))((((....(((...((...((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((..(....((...((((....((((...((...(......(.............).........(((....((.........))....)))..........................)....))...))))(..).....))))..))..)...)))))))))))..)).....((......))..))).(((.......)))..))))..((((....((((((((.((..(....(.......(((((....(.[..).....)))))(((((.....((....)).....)))))(...).......(((((((((.}.((.........))...(((((((.....(((....))).......))))))).]((((..((..(((((((..(((...((...(((((..((....))...)))))...))...))))))))..)))).(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).[..(((((.....}].)))))..((((((((.(((..(......((((.((((((..(((((.(((((((((.((((..()..))))....((.((((((.....)))))))).....)))))))))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.((((...........))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(((((.(....).).))))..a.)...)))))))))))[...((((((....((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((....))))))..)))))...)))).)))))...(((....((((.....>.......))))....))).))))..].....))))))...(....)......(((((((((.......)))))....((.(((((.(((....(((((....)))))...)))..)))))..))...))))....))))... Structure of the 50S subunit of the ribosome from Methicillin Resistant Staphylococcus aureus in complex with the antibiotic, radezolid; 23S rRNA 6wqq 2 111 3.1 RF00001 URS0001A24B3E_1280 32566908 0003735 0005840 1280 cuggugacuauagcaaggaggucacaccuguucccaugccgaacacagaaguuaagcuccuuagcgacgaugguaguccaacuuacguuccgcuagaguagaacguuccag <.<<........<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.....<....<..............>.....>.........>>..> (.(.........((((((((.....((((((...(.....)...))))..))....)))))).))..........(..............)................)..) Structure of the 50S subunit of the ribosome from Methicillin Resistant Staphylococcus aureus in complex with the antibiotic, radezolid; 5S rRNA 6wrs 1 2698 3.2 RF02540,RF02541,RF00002 URS0001A24B6A_1280 32566908 0003735 0005840 1280 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.((((......((((((((((.....(((..((((((((.((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))(((((((......))))))).(((((.((...........)).))).)).))....(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...((((()))))....{.((((.(..............(..((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))))...)........)...)))))....(((((((...[.......)))))))....}.(((((].[[[[)))))..)))......))..)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((..((((..[...))))..)))).{.(.(........).).((((((..(.(((((((.(((((..(((...(((.....)))...)))...((....))..((((.....)))).....))))).)))))))..((.(...((((((.....((((((((((.((.(...((((((......))))))...){.))...(((.(((((.......<))))))))..).))))))))).(.(((....[)))...).]))))))......).))).((((((....(((((....)))))(((((((((...((.((((((.....(((...(((.(((..........))).)))..)).).....)))).)).))..))))))).))..((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((.(((((......))))).)))).))...........]]].)...))))))))))...)))))))((((((.....))))))....))))))(.(((((((.((......(((((.((....))])))))...)).)))))))..).....))))))(......((....((((((.......))))))((((....(((...((...((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((..(....((...((((....((((...((...(......(.............).........(((....((.........))....)))..........................)....))...))))(..).....))))..))..)...)))))))))))..)).....((......))..))).(((.......)))..))))..((((....((((((((.((..(....(.......(((((....(.[..).....)))))(((((.....((....)).....)))))(...).......(((((((((.}.((.........))...(((((((.....(((....))).......))))))).]((((..((..(((((((..(((...((...(((((..((....))...)))))...))...))))))))..)))).(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).[..(((((.....}].)))))..((((((((.(((..(......((((.((((((..(((((.(((((((((.((((.(()).))))....((.((((((.....)))))))).....)))))))))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(((((.(....).).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((....))))))..)))))...)))).)))))...(((....((((.............))))....))).))))..]....))))))).(.(....).)....(((((((((.......)))))....((.(((((.(((....(((((....)))))...)))..)))))..))...))))....))))... Structure of the 50S subunit of the ribosome from Methicillin Resistant Staphylococcus aureus in complex with the antibiotic, tedizolid; 23S rRNA 6wrs 2 111 3.2 RF00001 URS0001A24B3E_1280 32566908 0003735 0005840 1280 cuggugacuauagcaaggaggucacaccuguucccaugccgaacacagaaguuaagcuccuuagcgacgaugguaguccaacuuacguuccgcuagaguagaacguuccag <<<<........<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.....<...<<..............>..>..>.........>>.>> ..((..........((((((......(((((...(.....)...))))..).....)))))).............(..............)...............))... Structure of the 50S subunit of the ribosome from Methicillin Resistant Staphylococcus aureus in complex with the antibiotic, tedizolid; 5S rRNA 6wru 1 2665 3.1 RF02540,RF02541,RF00002 URS0001A24B6A_1280 32566908 0003735 0005840 1280 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<<<<<......<<<<<<<<<<<....{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}....>>>>>>>>>>>.......<<<<..<<<<......>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<.<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>.>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<...<<<<<<<<<.....<<<...<<<<<<<..>>>>>>>..>>.>.....>>>>.>>>>>..>>>>>>>.>>..<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<.<<<<...>>>>.>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<.....>>>>>>....>>>>>><.<<<<<<<.<<......<<<<<.<<....>>.>>>>>...>>.>>>>>>>..>.....>>>>>><......<<....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<.........<<<<....<<<<...<<...<....<.<<<.....{...>>>.>.<....<<<<...<<..........>>...>>>>.....>.....<<.........>>........>....>>...>>>>.........>>>.>..>>>>>>>>..>>.....<<......>>>>>>>.<<<.......>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<<<<<<.<<<.>>>.>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<..<<...<<<<<<.<<....>>..>>>>>>...>>..>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<<.<<<<...>>>>....<<.<<<<<<.....>>>>>>>>.....>>>>>>>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<.>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<.<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>..>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.}..>>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>.<<<....>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>.. (((((......((((((((((.....(((..((((((((.((((......((((((.[[..[[[)))...].((((((...(((]]..]].)))......))))))...)))....(((....)))(((((((......))))))).(((((.((...........)).))).)).))....(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((((..........)))))....{.((((((((............(...(((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))....)......))))..)))))....(((((((...[.......)))))))....}.(((((].[[[[)))))..)))......))..)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((..((((..[...))))..)))).{.(.(........).).((((((..(.(((((((.(((((..(((...(((.....)))...)))...((....))..((((.....)))).....))))).)))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...){)))...(((.(((((........))))))))..).))))))))).(.(((....[)))...).]))))))......).))).((((((....(((((....))))).((((((((...((.((((((.....(((...(((((((..)))))))..)).).....)))).)).))..))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((.(.(((.))).).)))).))...........]]].)...))))))))))...)))))))((((((.....))))))....))))))(.(((((((.((......(((((.((....))])))))...)).)))))))..).....))))))(......((....((((((.......))))))((((....(((...((...((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]]((((.....(...((((....((((...((...(....(.(.......<.....).).......(((....(..........)....))).............(.........).........)....))...))))(..).....))))..)))))))))..)).....((......))..))).(((.......)))..))))..((((....((((((((.((..(....(.......(((((....(.[..).....)))))(((((.....(.).....)))))(...).......(((((((((.}.((.........))...(((((((.....(((....))).......))))))).]((((..((..(((((((..(((...((...(((((..((....))...)))))...))...))))))))..)))).(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).[..(((((.....}].)))))..((((((((.(((..(......((((.((((((..(((((.(((((((((.((((...))))....((.((((((.....)))))))).....)))))))))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((.)))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(((((.(....).).))))....)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.>..))))))..)))))...)))).)))))...(((....((((.............))))....))).))))..]....))))))).(((....)))....(((((((((.......)))))....((.(((((.(((....(((((....)))))...)))..)))))..))...))))....))))).. Structure of the 50S subunit of the ribosome from Methicillin Resistant Staphylococcus aureus in complex with an isomer of the tedizolid; 23S rRNA 6wru 2 112 3.1 RF00001 URS0001A24B3E_1280 32566908 0003735 0005840 1280 cuggugacuauagcaaggaggucacaccuguucccaugccgaacacagaaguuaagcuccuuagcgacgaugguaguccaacuuacguuccgcuagaguagaacguuccagg .<<<........<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>..........<..............>...............>>.>.. (.((........((((((((.....((((((...(.....)...))))..))....)))))).))..........(..............)...............))..). Structure of the 50S subunit of the ribosome from Methicillin Resistant Staphylococcus aureus in complex with an isomer of the tedizolid; 5S rRNA 6wu9 A 2739 2.9 RF02540,RF02541,RF00002 URS00021ED8E8_474186 33004869 0003735 0005840 474186 uuaagugaauaagggcgcacgguggaugccuuggcacuaggagccgaugaaggacgggacuaacaccgauaugcuuuggggagcuguaaguaagcuaugauccagagauuuccgaaugggggaacccaauaucuuuuauaggauauuacuuuucagugaauacauagcugauuagagguagacgcagagaacugaaacaucuuaguaccugcaggaagagaaagaaaauucgauucccugaguagcggcgagcgaaacgggaagagcccaaaccaacaagcuugcuuguugggguuguaggacuccgauaugguagucuguuaguauaguugaaggauuuggaaaauuccgcuaaagagggugaaagccccguagacgaaaugcugacaacaccuaggaggauccugaguacggcggaacacgagaaauuccgucggaauccgcggggaccaucccgcaaggcuaaauacucccuagugaccgauagugaaccaguaccgugagggaaaggugaaaagcaccccggaaggggagugaaauagauccugaaaccgugugccuacaacaagucaaagcucguuaaugagugauggcgugccuuuuguagaaugaaccggcgaguuacgauugcaugcgagguuaagucgaagagacggagccgcagcgaaagcgagucugaauagggcgaaugaguauguagucguagacccgaaaccaugugaucuacccauguccagguugaaggugcgguaaaacgcacuggaggaccgaacccacguacguugaaaagugcggggaugagguguggguagcggagaaauuccaaacgaacuuggagauagcugguucucuccgaaauagcuuuagggcuagccucggaauugagaaugauggagguagagcacuguuuggacuaguucagauaaacuccgaaugccauucauuuauauccgggagucagacugcgagugauaagauccguagucgaaagggaaacagcccagaccaccagcuaaggucccaaaauauauguuaaguggaaaaggaugugggguugcacagacaacuaucgagugacccugcgccgaaaauguaccggggcuaaacauauuaccgaagcuguggacuacaccauuagguguagugguaggagagcguucuaagggcguugaaggucgaucgugaggacggcuggagcgcuuagaagugagaaugccgguaugaguagcgaaagacaggugagaauccuguccaccguaugacuaagguuuccuggggaaggcucguccgcccaggguuagucgggaccuaagccgaggccgauaggcguaggcgauggacaacagguugauauuccuguaccaguuguuuguuugagcaauggagggacgcaguaggcuaaggaaugcaugcgauuggaagugcauguccaagcaaugagucuugaguagaguuaaaugcuuuacucuuuaaggacaaguugugacggggagcgaaauaguagcgaaguuccugacgucacacugccaagaaaagcuucuagugagaaaacaacugcccguaccguaaaccgacacagguagucgaggagaguauccuaaggugagcgagcgaacucucguuaaggaacucggcaaaaugaccccguaacuucgggagaaggggugcugacuucggucagccgcagugaauaggcccaagcgacuguuuaucaaaaacacaggucucugcaaaaucguaagaugaaguauaggggcugacgccugcccggugcuggaagguuaagaggauggguuagcuucggcgaagcucagaauugaagccccaguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgacccgcacgaaaggcguaacgauuugggcacugucucaacgagagacucggugaaauuuuaguaccugugaagaugcagguuacccgcgacaggacggaaagaccccauggagcuuuacuguaguuugauauugaguguuuaacccucuaacccgcaccacuaaucguggugggagacagugucagaugggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguucccucagaaugguuggaaaucauucgaagaguguaaaggcagaagggagcuugacugcgagaccuacaagucgagcagggacgaaagucgggcuuagugauccggugguuccgcauggaagggccaucgcucaacggauaaaagcuacccuggggauaacaggcuuaucucccccaagaguccacaucgacggggagguuuggcaccucgaugucggcucgucgcauccuggggcuguagucggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucccuauccgucgcgggcguuggaaauuugagaggagcuguccuuaguacgagaggaccgggauggacuuaccgcugguguaccaguuguucugccaagggcauugcuggguagcuauguagggaagggauaaacgcugaaagcaucuaagugugaagcccaccucaagaugagauuucccauuucuuuaagaaaguaagaccccugagagaugaucagguagauagguuggaaguggaaggcuagugauaguuggagcggaccaauacuaaucggucgaggacuuaac <<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<..<<<<<.........>>>>>..>>.>>....<<<<<......<<....>>.......>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..(((....<<<<<<<<....>>>>>>>>......<<<<<<<<...<.<<<.<<.<<<<<<<<<.<<<...<<<.<......>.>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>>.>>>>..>>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<....>>>>..................>>>>>>>>>>>.......<<<<..<<<<......>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>......>>>>>>>>>>>>>..<<.<..<<<<.<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>.>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<..<..<<<<<<<<<.....<<<...<<<<<<<<....>>>>>>>>..>>.>.....>>>>.>>>>>..>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<...>....>>>>>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<......>>>>>>>....>>>>>><.<<<<<<<.<<......<<<<<.<<....>>.>>>>>...>>.>>>>>>>..>.....>>>>>><......<<....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<.........<...<<<<....<<<<..<<<..<<<<<...........{...........<<..<<<<<..<<<<.<<<<<<<<<.....>>>>>>>>>.....>>>>..>>>>>...>>...<<.........>>....>>>>>...>>>...>>>>.........>>>>..>.......>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<....>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<..<<...<<<<<..<<....>>...>>>>>...>>..>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<<.<<<.<<<.>>>.>>>....<<.<<<<<<.....>>>>>>>>.....>>>>>>>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.}..>>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<......>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<..<<.....<<<<....>>>>....>>...>>>>>.>>>...>>>>....>>>>>>. ((((((......((((((((((.....(((..(((((((((((((......((((((.[[..[[[)))...].((((((...(((]]..]].)))......))))))...)))....(((....)))(((((((......))))))).((..(((((.........)))))..)).))....(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...((((((((....))))))))....{.((((((((.....(((.((.(((((((((.(((...(((.(......).)))[[(...).(((.....]])))...)))...))))))))))))))..))))..)))))....((((((((..[......))))))))....}.(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((..((((..[...))))..)))).<.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))......)))))))))))))..((.(...(((.((.....((((((((((.((((...((((((......))))))...).)))...(((.(((((.......A))))))))..).))))))))).(.(((....[)))...).])).)))......).))..((((((....(((((....)))))((((((((....((((((((((......((...((((((((....))))))))..)).......)))).))))).).)))))).))..((((.((.((......)).)).))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(...)...)))))))))).))...........]]].)...))))))))))...)))))))((((((........))))))....))))))(.(((((((.((......(((((.((....))])))))...)).)))))))..).....))))))(......((....((((((.......))))))((((....(((...((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]]((((((..........(...((((....((((..(((..(((((.....((....{.....))....((..(((((..((((.((((((.((.....)).)))))).....))))..)))))...))...((.........))....)))))...)))...))))(..).....))))..)........)))))))))).))).....((......))..))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.[..).....)))))((((((....))))))(...).......(((((((((...((.........))...(((((((.....(((....))).......))))))).].(((.(((..(((((((..(((...((...(((((..((....))...)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).)))))).....)).[..(((((.....>].)))))..((((((((.(((.((......((((.((((((..(((((.(((((((((.(((.(((.))).)))....((.((((((.....)))))))).....)))))))))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..a.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}..))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((..(..)..)).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...))))))). 50S subunit of 70S Ribosome Enterococcus faecalis MultiBody refinement; 23S rRNA 6wu9 B 116 2.9 RF00001 URS0000240630_474186 33004869 0003735 0005840 474186 ugugguggcgauagcgagaaggauacaccuguucccaugccgaacacagaaguuaagcuucuuagcgccgauuguagugaaggguuucccuuugugagaguaggacgucgccacgc <<<<<<<<<....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<.....<.<<<<<<<<...>>>>>>>>...>...>>..>>>>>>>>>. .((((((((....((((((((.....((((((...(.....)...))))..))....)))))).))..(........(..((((...))))..)........)...)))))))).. 50S subunit of 70S Ribosome Enterococcus faecalis MultiBody refinement; 5S rRNA 6ww6 E 17 3.8 URS00023119BE_1351 35150565 1351 aucggcaaaggagccca ...<<<......>>>.. .(.(((......))).) Crystal structure of EutV bound to RNA; eutP P2 6ww6 F 17 3.8 URS00023119BE_1351 35150565 1351 aaacacaauggcguguu .<<<<<......>>>>> .(((((......))))) Crystal structure of EutV bound to RNA; eutP P2 6ww6 D 17 3.8 URS00023119BE_1351 35150565 1351 aaacacaauggcguguu .<<<<<......>>>>> .(((((......))))) Crystal structure of EutV bound to RNA; eutP P2 6ww6 C 18 3.8 URS00023119BE_1351 35150565 1351 aaucggcaaaggagccca ..<.<<<......>>>.> ..(.(((......))).) Crystal structure of EutV bound to RNA; eutP P2 6wy2 A 10 1.928 URS000080E19F_32630 32941619 32630 ccggngccgg .......... .......... Crystal structure of RNA-10mer: CCGG(N4-methyl-C)GCCGG; RNA-10mer: CCGG(4-methyl-C)GCCGG 6wy2 B 10 1.928 URS000080E19F_32630 32941619 32630 ccggngccgg .......... .......... Crystal structure of RNA-10mer: CCGG(N4-methyl-C)GCCGG; RNA-10mer: CCGG(4-methyl-C)GCCGG 6wy2 C 10 1.928 URS000080E19F_32630 32941619 32630 ccggngccgg .......... .......... Crystal structure of RNA-10mer: CCGG(N4-methyl-C)GCCGG; RNA-10mer: CCGG(4-methyl-C)GCCGG 6wy2 D 10 1.928 URS000080E19F_32630 32941619 32630 ccggngccgg .......... .......... Crystal structure of RNA-10mer: CCGG(N4-methyl-C)GCCGG; RNA-10mer: CCGG(4-methyl-C)GCCGG 6wy2 E 10 1.928 URS000080E19F_32630 32941619 32630 ccggngccgg .......... .......... Crystal structure of RNA-10mer: CCGG(N4-methyl-C)GCCGG; RNA-10mer: CCGG(4-methyl-C)GCCGG 6wy3 A 10 1.647 URS000080E19F_32630 32941619 32630 ccggngccgg .......... .......... Crystal structure of RNA-10mer: CCGG(N4,N4-dimethyl-C)GCCGG; P212121 form; RNA (5'-R(*CP*CP*GP*GP*(LV2)P*GP*CP*CP*GP*G)-3') 6wy3 B 10 1.647 URS000080E19F_32630 32941619 32630 ccggngccgg .......... .......... Crystal structure of RNA-10mer: CCGG(N4,N4-dimethyl-C)GCCGG; P212121 form; RNA (5'-R(*CP*CP*GP*GP*(LV2)P*GP*CP*CP*GP*G)-3') 6wy3 C 10 1.647 URS000080E19F_32630 32941619 32630 ccggngccgg .......... .......... Crystal structure of RNA-10mer: CCGG(N4,N4-dimethyl-C)GCCGG; P212121 form; RNA (5'-R(*CP*CP*GP*GP*(LV2)P*GP*CP*CP*GP*G)-3') 6wy3 D 10 1.647 URS000080E19F_32630 32941619 32630 ccggngccgg .......... .......... Crystal structure of RNA-10mer: CCGG(N4,N4-dimethyl-C)GCCGG; P212121 form; RNA (5'-R(*CP*CP*GP*GP*(LV2)P*GP*CP*CP*GP*G)-3') 6wyv I 2897 2.75 RF02540,RF02541 URS00004B0F34_562 32968273 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccuu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<........>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<....<<.........>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<.....<<<.......>>>.....>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<......>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><.............<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>.>........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>..>.....>>>>>>>>..>>>>><<<<<.........>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.......>.....<<<<<.......>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<..<<<<<<<.<<.................<.<<.................................................>>.>........>>.>>>>>>>....<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>.. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))((((((......)))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((.........((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).)))))))...(.(((.....)))...)...).)))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(............)...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.((((.(.((...(...........)...))..........(........)...)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((((......))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(.............((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...(.((....((((..(((..((((((((((((...{{{.).))))))((..((((...(((((..(((((.((.....)))))))..)..))))..[))))...))(..((.((....)).))...))))))...)))...))))(..).....)).)...))....))))))))))).))).)))................)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))((((...........))))........((.(......).(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))).......)).{..(((((....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((...(((((((.(...((....................(.......................(..)..).....................))...).)))))).)....(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(.(((((....))).)).)....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(........(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).........).))))))))).. E. coli 50S ribosome bound to compounds 47 and VS1; 23S ribosomal RNA 6wyv J 118 2.75 RF00001 URS0000366A67_562 32968273 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (((.(((((.....((.(((((....(((((((...(.....)...))))..)))...)))))..)).((.......((((((((...)))))))).......))...))))).))). E. coli 50S ribosome bound to compounds 47 and VS1; 5S ribosomal RNA 6x5m R 39 2.5 URS0001A24B4B_32630 34871450 32630 ggguuuuuccuucgaaacacgaagguuuuuaucccugcc <<<.....<<<<<<.....>>>>>>.......>>>.... (((.....((((((.....)))))).......))).... Crystal structure of a stabilized PAN ENE bimolecular triplex with a GC-clamped polyA tail, in complex with Fab-BL-3,6.; ggPAN RNA (39-MER) 6x5m A 12 2.5 URS0001A24B46_32630 34871450 32630 ggcaaaaaaaaa ............ ............ Crystal structure of a stabilized PAN ENE bimolecular triplex with a GC-clamped polyA tail, in complex with Fab-BL-3,6.; ggcA9 RNA (12-MER) 6x5m r 39 2.5 URS0001A24B4B_32630 34871450 32630 ggguuuuuccuucgaaacacgaagguuuuuaucccugcc <<<.....<<<<<<.....>>>>>>.......>>>.... (((.....((((((.....)))))).......))).... Crystal structure of a stabilized PAN ENE bimolecular triplex with a GC-clamped polyA tail, in complex with Fab-BL-3,6.; ggPAN RNA (39-MER) 6x5m a 12 2.5 URS0001A24B46_32630 34871450 32630 ggcaaaaaaaaa ............ ............ Crystal structure of a stabilized PAN ENE bimolecular triplex with a GC-clamped polyA tail, in complex with Fab-BL-3,6.; ggcA9 RNA (12-MER) 6x5n R 39 3.3 URS0001A24B4B_32630 34871450 32630 ggguuuuuccuucgaaacacgaagguuuuuaucccugcc <<<.....<<<<<<.....>>>>>>.......>>>.... (((.....((((((.....)))))).......))).... Crystal structure of a stabilized PAN ENE bimolecular triplex with a GC-clamped polyA tail, in complex with Fab-BL-3,6; ggPAN RNA (39-MER) 6x5n A 12 3.3 URS0001A24B46_32630 34871450 32630 ggcaaaaaaaaa ............ ............ Crystal structure of a stabilized PAN ENE bimolecular triplex with a GC-clamped polyA tail, in complex with Fab-BL-3,6; ggcA9 RNA (12-MER) 6x5n r 39 3.3 URS0001A24B4B_32630 34871450 32630 ggguuuuuccuucgaaacacgaagguuuuuaucccugcc <<<.....<<<<<<.....>>>>>>.......>>>.... (((.....((((((.....)))))).......))).... Crystal structure of a stabilized PAN ENE bimolecular triplex with a GC-clamped polyA tail, in complex with Fab-BL-3,6; ggPAN RNA (39-MER) 6x5n a 12 3.3 URS0001A24B46_32630 34871450 32630 ggcaaaaaaaaa ............ ............ Crystal structure of a stabilized PAN ENE bimolecular triplex with a GC-clamped polyA tail, in complex with Fab-BL-3,6; ggcA9 RNA (12-MER) 6x6t 7 33 3.2 32820061 32630 auguuuuuuuuuuuuuuuuuuuuuggugagagg ................................. ................................. Cryo-EM structure of an Escherichia coli coupled transcription-translation complex B1 (TTC-B1) containing an mRNA with a 24 nt long spacer, transcription factors NusA and NusG, and fMet-tRNAs at P-site and E-site; mRNA with 24 nt long spacer 6x6t A 76 3.2 RF00005 URS000080DFF5_562 32820061 0030533 0006412 562 cgcgggguggagcagccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((........)))).(((((.......))))).....(((((.......)))))))))))..... Cryo-EM structure of an Escherichia coli coupled transcription-translation complex B1 (TTC-B1) containing an mRNA with a 24 nt long spacer, transcription factors NusA and NusG, and fMet-tRNAs at P-site and E-site; E-site and P-site tRNA (fMet) 6x6t B 76 3.2 RF00005 URS000080DFF5_562 32820061 0030533 0006412 562 cgcgggguggagcagccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<........>>>>.<<<<.........>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((........)))).(((...........))).....(((((.......)))))))))))..... Cryo-EM structure of an Escherichia coli coupled transcription-translation complex B1 (TTC-B1) containing an mRNA with a 24 nt long spacer, transcription factors NusA and NusG, and fMet-tRNAs at P-site and E-site; E-site and P-site tRNA (fMet) 6x6t D 1524 3.2 RF00177,RF01959,RF01960 URS00000ABFE9_562 32820061 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccggccagcagcccgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgauaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgccguacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgaacaagguaaccguaggggccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<......>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>..<<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>>.<<<<<(((...<<<<<.......)))........>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<......>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<......<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>..>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>......<<..<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>....>>........<<<<<<<<<..>>>>>>>>>...... ........((((..[.[[[[.)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((........))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..........)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((((.......)))))))).....)....)))))....)..((((([[[...(((((....(..]]]).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))..]]]].](((((.(((((((.((..(((((..((((((((((......((......))..........(((((((..(...((.((((..(((.(((....))).))).............))))..))).((.(.(...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..(..((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))....)...)..)..(((((((((..)))))))))}..... Cryo-EM structure of an Escherichia coli coupled transcription-translation complex B1 (TTC-B1) containing an mRNA with a 24 nt long spacer, transcription factors NusA and NusG, and fMet-tRNAs at P-site and E-site; 16S rRNA 6x6t a 2880 3.2 RF02540,RF02541 URS0000B21DEA_562 32820061 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaacccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcggggcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacgguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccucccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccgaacaaacgguccuaagguagcgaaauccuugucggguaaguuccgacugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugagaugcaguguacccgcggcaagacggaaagaccccguaaccuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgggauaacaggcgauaccgcccaagaguucauaucgacggcgguguuuggcacucggucggcucaucacauccuggggcugaaguaggucccaaggguauggcguucgccauuuaaagugguacgcgagcggguuuagaacgucgugagacagucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<.<....<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>..>>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>>.>>...............<<....>>....>>.........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<.....>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>>.>>...>>>>>>>.>...<<<<<<<<<.......>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....[[[...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<.....>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>.>......>>>>>>>>..>>>>..<<<<......>>>>.........<..........<<<<<<.....>>>>>>....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<.......>>>>>..<<<<<<<<.<<<.<<......<.<<..<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<..<<.......<<<<<<<<....>>>>>>>>....>>............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>..............>>>....>>>........<<...<<<<<<...<<.......>>...>>>>>>.....>>......<<.<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<....>>>>>.....>>>>>..>...>>.>>....<.<<<<<....>>>.>>>....>>..>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]].>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((.(.....)).)))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((..(.........)...))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((.......)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(.((..(((..((((.......))))..))).....(..(((......))))..)).)...)))..))))).))...........]]].)...))))))))))...)))))))(((((..((....))..)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((.(((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....)))).)))))).))).))).....((.....)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.((..(((((((..(((........(((((..((....))...)))))........))))))))..))))....((......))...........((.........(((((.......))))).)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((....]}.)))))..((((((((.(((.((......(.((.((((..(((((.(((.(((((.(((((((((((.(.((.(..........(((...(((.......(((((((....)))))))....))).............))).).)).).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((.....[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}.......)))..).)))......(.((.(.((((((...((.......))...))))))...).))..)....(.((.((((((..(((((((((......))))))..))).(((((....))))).....)))))..)...)).).....(.(((((....))).)))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((.(....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Cryo-EM structure of an Escherichia coli coupled transcription-translation complex B1 (TTC-B1) containing an mRNA with a 24 nt long spacer, transcription factors NusA and NusG, and fMet-tRNAs at P-site and E-site; 23S rRNA 6x6t d 120 3.2 RF00001 URS0000049E57_562 32820061 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. .(((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))).. Cryo-EM structure of an Escherichia coli coupled transcription-translation complex B1 (TTC-B1) containing an mRNA with a 24 nt long spacer, transcription factors NusA and NusG, and fMet-tRNAs at P-site and E-site; 5S rRNA 6x7f 7 33 3.5 32820061 32630 auguuuuuuuuuuuuuuuuuuuuuggugagagg ................................. ................................. Cryo-EM structure of an Escherichia coli coupled transcription-translation complex B2 (TTC-B2) containing an mRNA with a 24 nt long spacer, transcription factors NusA and NusG, and fMet-tRNAs at P-site and E-site; mRNA with 24 nt long spacer 6x7f A 76 3.5 RF00005 URS000080DFF5_562 32820061 0030533 0006412 562 cgcgggguggagcagccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((........)))).(((((.......))))).....(((((.......)))))))))))..... Cryo-EM structure of an Escherichia coli coupled transcription-translation complex B2 (TTC-B2) containing an mRNA with a 24 nt long spacer, transcription factors NusA and NusG, and fMet-tRNAs at P-site and E-site; E-site and P-site tRNA (fMet) 6x7f B 76 3.5 RF00005 URS000080DFF5_562 32820061 0030533 0006412 562 cgcgggguggagcagccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<........>>>>.<<<<.........>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((........)))).(((...........))).....(((((.......)))))))))))..... Cryo-EM structure of an Escherichia coli coupled transcription-translation complex B2 (TTC-B2) containing an mRNA with a 24 nt long spacer, transcription factors NusA and NusG, and fMet-tRNAs at P-site and E-site; E-site and P-site tRNA (fMet) 6x7f D 1524 3.5 RF00177,RF01959,RF01960 URS00000ABFE9_562 32820061 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccggccagcagcccgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgauaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgccguacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgaacaagguaaccguaggggccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<......>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>..<<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>>.<<<<<(((...<<<<<.......)))........>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<......>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<......<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>..>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>......<<..<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>....>>........<<<<<<<<<..>>>>>>>>>...... ........((((..[.[[[[.)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((........))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..........)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((((.......)))))))).....)....)))))....)..((((([[[...(((((....(..]]]).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))..]]]].](((((.(((((((.((..(((((..((((((((((......((......))..........(((((((..(...((.((((..(((.(((....))).))).............))))..))).((.(.(...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..(..((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))....)...)..)..(((((((((..)))))))))}..... Cryo-EM structure of an Escherichia coli coupled transcription-translation complex B2 (TTC-B2) containing an mRNA with a 24 nt long spacer, transcription factors NusA and NusG, and fMet-tRNAs at P-site and E-site; 16S rRNA 6x7f a 2880 3.5 RF02540,RF02541 URS0000B21DEA_562 32820061 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaacccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcggggcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacgguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccucccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccgaacaaacgguccuaagguagcgaaauccuugucggguaaguuccgacugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugagaugcaguguacccgcggcaagacggaaagaccccguaaccuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgggauaacaggcgauaccgcccaagaguucauaucgacggcgguguuuggcacucggucggcucaucacauccuggggcugaaguaggucccaaggguauggcguucgccauuuaaagugguacgcgagcggguuuagaacgucgugagacagucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<.<....<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>..>>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>>.>>...............<<....>>....>>.........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<.....>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>>.>>...>>>>>>>.>...<<<<<<<<<.......>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....[[[...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<.....>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>.>......>>>>>>>>..>>>>..<<<<......>>>>.........<..........<<<<<<.....>>>>>>....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<.......>>>>>..<<<<<<<<.<<<.<<......<.<<..<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<..<<.......<<<<<<<<....>>>>>>>>....>>............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>..............>>>....>>>........<<...<<<<<<...<<.......>>...>>>>>>.....>>......<<.<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<....>>>>>.....>>>>>..>...>>.>>....<.<<<<<....>>>.>>>....>>..>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]].>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((.(.....)).)))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((..(.........)...))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((.......)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(.((..(((..((((.......))))..))).....(..(((......))))..)).)...)))..))))).))...........]]].)...))))))))))...)))))))(((((..((....))..)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((.(((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....)))).)))))).))).))).....((.....)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.((..(((((((..(((........(((((..((....))...)))))........))))))))..))))....((......))...........((.........(((((.......))))).)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((....]}.)))))..((((((((.(((.((......(.((.((((..(((((.(((.(((((.(((((((((((.(.((.(..........(((...(((.......(((((((....)))))))....))).............))).).)).).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((.....[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}.......)))..).)))......(.((.(.((((((...((.......))...))))))...).))..)....(.((.((((((..(((((((((......))))))..))).(((((....))))).....)))))..)...)).).....(.(((((....))).)))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((.(....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Cryo-EM structure of an Escherichia coli coupled transcription-translation complex B2 (TTC-B2) containing an mRNA with a 24 nt long spacer, transcription factors NusA and NusG, and fMet-tRNAs at P-site and E-site; 23S rRNA 6x7f d 120 3.5 RF00001 URS0000049E57_562 32820061 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. .(((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))).. Cryo-EM structure of an Escherichia coli coupled transcription-translation complex B2 (TTC-B2) containing an mRNA with a 24 nt long spacer, transcription factors NusA and NusG, and fMet-tRNAs at P-site and E-site; 5S rRNA 6x7k 7 33 3.1 32820061 32630 auguuuuuuuuuuuuuuuuuuuuuggugagagg ................................. ................................. Cryo-EM structure of an Escherichia coli coupled transcription-translation complex B3 (TTC-B3) containing an mRNA with a 24 nt long spacer, transcription factors NusA and NusG, and fMet-tRNAs at P-site and E-site; mRNA with 24 nt long spacer 6x7k A 76 3.1 RF00005 URS000080DFF5_562 32820061 0030533 0006412 562 cgcgggguggagcagccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((........)))).(((((.......))))).....(((((.......)))))))))))..... Cryo-EM structure of an Escherichia coli coupled transcription-translation complex B3 (TTC-B3) containing an mRNA with a 24 nt long spacer, transcription factors NusA and NusG, and fMet-tRNAs at P-site and E-site; E-site and P-site tRNA (fMet) 6x7k B 76 3.1 RF00005 URS000080DFF5_562 32820061 0030533 0006412 562 cgcgggguggagcagccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<........>>>>.<<<<.........>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((........)))).(((...........))).....(((((.......)))))))))))..... Cryo-EM structure of an Escherichia coli coupled transcription-translation complex B3 (TTC-B3) containing an mRNA with a 24 nt long spacer, transcription factors NusA and NusG, and fMet-tRNAs at P-site and E-site; E-site and P-site tRNA (fMet) 6x7k D 1524 3.1 RF00177,RF01959,RF01960 URS00000ABFE9_562 32820061 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccggccagcagcccgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgauaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgccguacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgaacaagguaaccguaggggccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<......>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>..<<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>>.<<<<<(((...<<<<<.......)))........>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<......>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<......<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>..>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>......<<..<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>....>>........<<<<<<<<<..>>>>>>>>>...... ........((((..[.[[[[.)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((........))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..........)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((((.......)))))))).....)....)))))....)..((((([[[...(((((....(..]]]).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))..]]]].](((((.(((((((.((..(((((..((((((((((......((......))..........(((((((..(...((.((((..(((.(((....))).))).............))))..))).((.(.(...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..(..((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))....)...)..)..(((((((((..)))))))))}..... Cryo-EM structure of an Escherichia coli coupled transcription-translation complex B3 (TTC-B3) containing an mRNA with a 24 nt long spacer, transcription factors NusA and NusG, and fMet-tRNAs at P-site and E-site; 16S rRNA 6x7k a 2880 3.1 RF02540,RF02541 URS0000B21DEA_562 32820061 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaacccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcggggcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacgguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccucccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccgaacaaacgguccuaagguagcgaaauccuugucggguaaguuccgacugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugagaugcaguguacccgcggcaagacggaaagaccccguaaccuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgggauaacaggcgauaccgcccaagaguucauaucgacggcgguguuuggcacucggucggcucaucacauccuggggcugaaguaggucccaaggguauggcguucgccauuuaaagugguacgcgagcggguuuagaacgucgugagacagucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<.<....<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>..>>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>>.>>...............<<....>>....>>.........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<.....>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>>.>>...>>>>>>>.>...<<<<<<<<<.......>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....[[[...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<.....>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>.>......>>>>>>>>..>>>>..<<<<......>>>>.........<..........<<<<<<.....>>>>>>....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<.......>>>>>..<<<<<<<<.<<<.<<......<.<<..<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<..<<.......<<<<<<<<....>>>>>>>>....>>............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>..............>>>....>>>........<<...<<<<<<...<<.......>>...>>>>>>.....>>......<<.<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<....>>>>>.....>>>>>..>...>>.>>....<.<<<<<....>>>.>>>....>>..>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]].>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((.(.....)).)))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((..(.........)...))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((.......)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(.((..(((..((((.......))))..))).....(..(((......))))..)).)...)))..))))).))...........]]].)...))))))))))...)))))))(((((..((....))..)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((.(((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....)))).)))))).))).))).....((.....)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.((..(((((((..(((........(((((..((....))...)))))........))))))))..))))....((......))...........((.........(((((.......))))).)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((....]}.)))))..((((((((.(((.((......(.((.((((..(((((.(((.(((((.(((((((((((.(.((.(..........(((...(((.......(((((((....)))))))....))).............))).).)).).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((.....[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}.......)))..).)))......(.((.(.((((((...((.......))...))))))...).))..)....(.((.((((((..(((((((((......))))))..))).(((((....))))).....)))))..)...)).).....(.(((((....))).)))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((.(....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Cryo-EM structure of an Escherichia coli coupled transcription-translation complex B3 (TTC-B3) containing an mRNA with a 24 nt long spacer, transcription factors NusA and NusG, and fMet-tRNAs at P-site and E-site; 23S rRNA 6x7k d 120 3.1 RF00001 URS0000049E57_562 32820061 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. .(((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))).. Cryo-EM structure of an Escherichia coli coupled transcription-translation complex B3 (TTC-B3) containing an mRNA with a 24 nt long spacer, transcription factors NusA and NusG, and fMet-tRNAs at P-site and E-site; 5S rRNA 6x9q 7 33 4.8 32820061 32630 auguuuuuuuuuuuuuuuuuuuuuggugagagg ................................. ................................. Cryo-EM structure of an Escherichia coli coupled transcription-translation complex B3 (TTC-B3) containing an mRNA with a 27 nt long spacer, transcription factors NusA and NusG, and fMet-tRNAs at P-site and E-site; mRNA with 27 nt long spacer 6x9q A 76 4.8 RF00005 URS000080DFF5_562 32820061 0030533 0006412 562 cgcgggguggagcagccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((........)))).(((((.......))))).....(((((.......)))))))))))..... Cryo-EM structure of an Escherichia coli coupled transcription-translation complex B3 (TTC-B3) containing an mRNA with a 27 nt long spacer, transcription factors NusA and NusG, and fMet-tRNAs at P-site and E-site; E-site and P-site tRNA (fMet) 6x9q B 76 4.8 RF00005 URS000080DFF5_562 32820061 0030533 0006412 562 cgcgggguggagcagccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<........>>>>.<<<<.........>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((........)))).(((...........))).....(((((.......)))))))))))..... Cryo-EM structure of an Escherichia coli coupled transcription-translation complex B3 (TTC-B3) containing an mRNA with a 27 nt long spacer, transcription factors NusA and NusG, and fMet-tRNAs at P-site and E-site; E-site and P-site tRNA (fMet) 6x9q D 1524 4.8 RF00177,RF01959,RF01960 URS00000ABFE9_562 32820061 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccggccagcagcccgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgauaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgccguacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgaacaagguaaccguaggggccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<......>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>..<<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>>.<<<<<(((...<<<<<.......)))........>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<......>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<......<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>..>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>......<<..<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>....>>........<<<<<<<<<..>>>>>>>>>...... ........((((..[.[[[[.)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((........))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..........)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((((.......)))))))).....)....)))))....)..((((([[[...(((((....(..]]]).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))..]]]].](((((.(((((((.((..(((((..((((((((((......((......))..........(((((((..(...((.((((..(((.(((....))).))).............))))..))).((.(.(...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..(..((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))....)...)..)..(((((((((..)))))))))}..... Cryo-EM structure of an Escherichia coli coupled transcription-translation complex B3 (TTC-B3) containing an mRNA with a 27 nt long spacer, transcription factors NusA and NusG, and fMet-tRNAs at P-site and E-site; 16S rRNA 6x9q a 2880 4.8 RF02540,RF02541 URS0000B21DEA_562 32820061 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaacccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcggggcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacgguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccucccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccgaacaaacgguccuaagguagcgaaauccuugucggguaaguuccgacugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugagaugcaguguacccgcggcaagacggaaagaccccguaaccuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgggauaacaggcgauaccgcccaagaguucauaucgacggcgguguuuggcacucggucggcucaucacauccuggggcugaaguaggucccaaggguauggcguucgccauuuaaagugguacgcgagcggguuuagaacgucgugagacagucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<.<....<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>..>>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>>.>>...............<<....>>....>>.........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<.....>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>>.>>...>>>>>>>.>...<<<<<<<<<.......>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....[[[...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<.....>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>.>......>>>>>>>>..>>>>..<<<<......>>>>.........<..........<<<<<<.....>>>>>>....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<.......>>>>>..<<<<<<<<.<<<.<<......<.<<..<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<..<<.......<<<<<<<<....>>>>>>>>....>>............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>..............>>>....>>>........<<...<<<<<<...<<.......>>...>>>>>>.....>>......<<.<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<....>>>>>.....>>>>>..>...>>.>>....<.<<<<<....>>>.>>>....>>..>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]].>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((.(.....)).)))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((..(.........)...))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((.......)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(.((..(((..((((.......))))..))).....(..(((......))))..)).)...)))..))))).))...........]]].)...))))))))))...)))))))(((((..((....))..)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((.(((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....)))).)))))).))).))).....((.....)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.((..(((((((..(((........(((((..((....))...)))))........))))))))..))))....((......))...........((.........(((((.......))))).)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((....]}.)))))..((((((((.(((.((......(.((.((((..(((((.(((.(((((.(((((((((((.(.((.(..........(((...(((.......(((((((....)))))))....))).............))).).)).).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((.....[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}.......)))..).)))......(.((.(.((((((...((.......))...))))))...).))..)....(.((.((((((..(((((((((......))))))..))).(((((....))))).....)))))..)...)).).....(.(((((....))).)))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((.(....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Cryo-EM structure of an Escherichia coli coupled transcription-translation complex B3 (TTC-B3) containing an mRNA with a 27 nt long spacer, transcription factors NusA and NusG, and fMet-tRNAs at P-site and E-site; 23S rRNA 6x9q d 120 4.8 RF00001 URS0000049E57_562 32820061 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. .(((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))).. Cryo-EM structure of an Escherichia coli coupled transcription-translation complex B3 (TTC-B3) containing an mRNA with a 27 nt long spacer, transcription factors NusA and NusG, and fMet-tRNAs at P-site and E-site; 5S rRNA 6xa1 L5 3510 2.8 RF02540,RF02543 URS00021ED9B7_9606 33009412 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgggggcgcgggacauguggcguacggaagacccgcuccccggggggcccaaguccuucugaucgaggccccguggacggugugaggccgguagcggcccccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaanggaaaguugaaaagaacuuugaagngngaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgggcggaucugggaccguccccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucggccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcgcucuccccccugggggggccgggccaccccucccacggcgcgaccgcuggggcggacuguucccagugcgccccgggcgggucgcgccgucgggcccggggggccacgcgcgcgucccgggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccnucuugnaacncggaccaaggagunuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggccgaggugggaucccgaggccucuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuagnacccnanagauggugancuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauagnggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcagacccgacgcccgccacgcaguuuuauccgguaaagcgaaugauuagaggucuuggucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcngaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagcggcgggccggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaunuuggugguagunnnaaauauucaaacgagaacuuugaaggccgaaguggngaaggguuccaugugaacagnanuugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccnuauccgcagcaggucuncaaggugaacngccucuggnauguuggaacaanguagguaagggaagucggcaagcnggauccguaacuucnggauaaggauuggcucuaagggcugggucggucgcggccggcgccuagcagccgacuuagaacuggugcggaccaggngaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugccnagugcucugaaugucanagugangaaauucaaugaagcgcggnuaaacggcgggaguancuaugacucucuuaagguagcnaanugccucnucaucuaauuagugangcgcaugaanggaugancgagnuucccacugunccuaccuacuauccagcgaaaccacngncaagggaacgggcuuggnggaaucagcggngaaagaagacccuguugagcuugacncuagucuggcacggugaagagacuuuuuucacugacccggugaggcgggggggcgagcucucgcuucuggcgccaagcgcccggcgccgggcgcgacccgcuccggggacagugccagguggggaguuugacugnggcgguacaccugucaaacgguancgcaggnnuccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucagnacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggangugucagaaaaguuaccacagngauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuungaugucggnucuuccuaucauugugaagcagaauucaccaagcguungaunnuucacccacuaauagggaacgugngcugggnuuagancgucgugagacagguuaguuuuacccuacugaugnuguguuguugccaugguaauccugcucaguacgagaggaaccgcagnuncanacauuugguguaunugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacagcgccgcggagccucgguuggccucggauagccggucccggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<<...<<<<<<<<<<.>>>>>>.>>>>.....>>>>>..<<<<<<<<<<...<<..<<<<<<<<....<<<<......>>>>.((......<<<.....))>>>...>.>>>>>>>.>>..>>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<<<..<<<....<<<<<.<<<.>>>>>>>>..>>>>>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<.<<<<<<<<<<.<<<<...<<..<<<....<<<<......<<<<<..>>>>>.......>>>>...>>>........>>>>>>...>>>>>>>>>>....................<<<<<<.<<<<<<..>>>>>>.<<<<<<.<<<<.<<<<<<<<<<<.<<<<<<<<<<<.<<<<....>>>>.>>>>>>>.>>>>.>.>>>>>>>.>>>...>>>>>>>>.>>..<<<<<<<..>>>>>.>>....>>>>>>......>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<..>>>..<<<<<...<<<..<<<..((((..(((>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<......................<<<.<<<<<<<<<...<<<....<<<..<.<<<..........>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<..........<...<.....................>.........................>.....>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<..........)))..))))...<<...>>..................>>>>>>>>>....>>>>>>.<<<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>.>>.....>>>>>><<<....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<.............>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<..<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<...............>>>>><<.<<<<<<<<<<<.......................>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>...>>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<..<<<<<<<<<.<<<<<<<<...>>>>>>>>...<<<<<.....<<<<...........................<<<<<<<<..>>>>>>>>..>>>>..>>>>>....>>>>>>>>>...>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>><<<<....>>>>>>)))].....<<<<<<<..<<<..)))))).>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<]]].>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>..<<<<<<<.<<..<<<<....<<<........<<<<<.<<..>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>..............>>>>..>>>>>>>>><<<<<....................<<.<<<<<<<.<<.....<<<<....<<<<<......>>>>>...>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..(((((((((((.)))))).))))....))))....((((((((((...((..((((((((..({((((......)))))[[(...).(((....}]])))...).))))))).))..))))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....(((((((((((..(((....(((((.(((.))))))))..))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((..(.((((......(((((()))))).......))))..))))........))))))..)))))))))))....................((((((.((((((())))))).((((((.((((.(((((((((((.(((((((((((.((((....)))).)))))).))))).).))))))).)))...)))))))).))..(((((((()))))).))..[.)))))).....))).)))))...)))))...)))))))).<((((........))))((((((....(((((((((((((..(((..((((..........)))..)..)))...((....))...(((..)))..(((((...(((..(((..[[.....[[)))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((......................(((.((((((((.....((.....((....(((..(..().).)))....))...))......))))))...(((((((((.(......))))))))))....))))))))))))..))..((((..(.((.....)).)..))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.....{..............................................................)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((..........]].....]]]..............(...)........)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((..((((((....((.....))..)))))....[[(((.((...(.....(((....)))..........((.((((.............)))))).......)....))...(((((........)))))]]((((....(((((...((((((......))))))..((((....)))...(...((((((...((((((((((((((((((((((...{{{...)))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....(((((((.......))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).))).))).....((......)).)))).((((.....))))..)))....(((......((((((..((..(....(.......(((((....(.[..).....)))))((.(((((((((((.....(.......).........)))))..)))))).))(...).......(((((((((.>.(...........)...(((((((....((((.....))))......))))))).].(.(.(((..((((((.(..((......((.(....).))......)))))))..)))))(.(.(.........).).)........((..........(((((.......)))))..)..)....).)....)).))))))).)..)))..))))))...)))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.(((((...(((((.(((((((((.((((((((...))))))))...(((((.....((((...........................((((((((()))))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(..((....((....{..))....)).)(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}.....)))..)))))).......(....(.((((.(...((.......))...).))))...)....)........((((.((((((..(.(.(.(((......))).)...).).(((.(.....).))).....)))))..)...))).)......((((((....))).)))...a.))..))).))))).....(.((.(.(..(((..(.(((((......(....).....))))).)(((.....((((....((.(((((((}}}.)))))..)).))...))))....))).(((....((((.....}.......))))....)))..)))...).).)).)..(((((((.((..((((.(..(((........(((((.((())).))))).......)))...(((..((((....((((.(((((((......)))))))))))...))))..)))...........)..))))..)))))))))(((((....(.......).......((.(((((((.((.....(.((.(..(((((......)))))..))).)....))....)))).))).))..))))).. Structure of a drug-like compound stalled human translation termination complex; 28S rRNA 6xa1 L7 120 2.8 RF00001 URS000002B0D5_9606 33009412 0003735 0005840 9606 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. Structure of a drug-like compound stalled human translation termination complex; 5S rRNA 6xa1 L8 155 2.8 RF00002 URS00021ED94B_9606 33009412 0003735 0005840 9606 gacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauuncaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu ........................................<<<<<<.<<.....>>>.....(.<<<......>>.............>>>..)...>>>....<<....>><<<<<<<<<.....>>>>>>>>>.................... ........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))(((((((((.....))))))))).................... Structure of a drug-like compound stalled human translation termination complex; 5.8S rRNA 6xa1 S2 1590 2.8 RF01960,RF01959,RF00177 URS00021ED9C0_9606 33009412 0003735 0005840 9606 uaccugguugauccugccaguagcaunugcuugucucaaagauuaagccaugcaugucuaaguacgcacggcuacagugaaacugcgaauggcucnuuaaaucaguuauggunccuunggucgcucgcacuuggauaacugugguanuucuagngcuaananaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgcccuggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgaunccggaganggagccugagaaacggcuaccacauncaaggnaggcagcaggcgcgcnaauuacccacucccgacccggggangungugangaaaaauaacaauacaggaccuguaauuggaaugaguccacuuuaanuccuuuaacgaggnuccauuggagngcaagucuggugccagcagncgcgguaauuccagcuccaauancguauauuaaaguugcugcaguunaaaagcucguaguungaucuuuuuacuuugaaaaaauuagaguguucaaagcaggcccgccuggauaccgcagcuaggaauaaungaauaggaccgcgugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagancgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggcguuauugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacncaacacgggaaaccucacccggcccggacacggacagganugacagauugauagcucuuucucgauuccguggguggngnugcauggcnguucuuaguugguggagcgauuugucugguuaauuccgauaacgancgagacunuggcaugcuaacuaguuacgcgacccagcggucggcguaacuncuuagagggacaaguggcguucagccacccgagauugagcaauaacangucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcguguccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgagnaauucccaguaagugcgggucauaagcuugcguugauunagucccugcccuuuguacacaccgnccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccgcugagaagacggucgaacungacuaucuagaggaaguaaaagucguancaagguuucnguaggugnnccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<.........<<<.<<<..<<....<<....<<.......>>...>>.>>......<<........<<<.<....<<....<<<<<.........<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<<<....>>>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<<..>>>>>>>>.>>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>......>>.>.....<<<<<<<<<.>>>>>>.>>>......<<..<...........>..>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<.....<<<<<<.<.......<<...<.......>.<<<<..>>>>...>>......>.>>>..>>>........<.<<.<..>.>>.>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<.>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<......>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<........<<........>>..........<<<<<......<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<....>>>>.>>>>>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.......>>>>>......>>>>.>>>.....<<.<<<........<.<<<.<<<<....>>>>.>>>....>.........>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<.>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))((...(((((......(..((.....(((.(((..((....((....((.......))...))[))......(((.......(((.(.(..((....((((....((....((.....((.(((.....))).))......))......)).((((...((((((....))))))...))))((..(((((...(......)..)))))......)).(.((((..(((..))).))))).).)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)........((((((((...))))).)))....(.((..(...........)..))......)..((((([.....(.(.((.....((...])).......)).)))))))..)))))...))..[......(.([[...(.(.((...(((..(.....(..(((.(........(..((.......)).(((..)))....).......).)))....)........(.((.(()).)).)....)....(((..(...(...(((...(((.((((((((...(..........)......)))))))).))).......((....))....)))..)...)...))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((..((..(.((((((.((((.)))))))))).)..))....((..]]))...))...].))))).).(((......((.(....).))....)))...]]].]((((..(((((((..((..((.((..(((..(((((.......(........)...........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....((..(((((....)))..(.((......)))...))..))....(((...(...((.(..(((((((((((((.).)))).))))))))..).))..).....(((((.....)))))........)))....))).))).....).))))).....).)))))...)).)))..))).(...((.(((........(.(((.((((....)))).)))....).........))).))......(.....((((............)))).....)..)..)).)).....((((((((.......))))))))......))...))))))).)).))..(.(..((.(..((((.((..(.((((((((.(((..((((.((...(((((.)))))...)).))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}........ Structure of a drug-like compound stalled human translation termination complex; 18S rRNA 6xa1 Bv 75 2.8 RF00005 URS00021ED978_9606 33009412 0030533 9606 gucucugunncgcaancggagcgcnuucggcuguunaccgaaagnnuggugguucgngcccacccagggacgcca <<<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((.(((..((((.....[.))))...(((.......))).......((.((..]....)).))))).))).... Structure of a drug-like compound stalled human translation termination complex; P-tRNA 6xa1 k 13 2.8 33009412 9606 uccaaacuaauuu ............. ............. Structure of a drug-like compound stalled human translation termination complex; mRNA 6xdq 7 35 3.7 32820061 32630 auguuuuuuuuuuuuuuuuuuuuuuuggugagagg ................................... ................................... Cryo-EM structure of an Escherichia coli coupled transcription-translation complex B3 (TTC-B3) containing an mRNA with a 30 nt long spacer, transcription factors NusA and NusG, and fMet-tRNAs at P-site and E-site; mRNA with 30 nt long spacer 6xdq A 76 3.7 RF00005 URS000080DFF5_562 32820061 0030533 0006412 562 cgcgggguggagcagccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((........)))).(((((.......))))).....(((((.......)))))))))))..... Cryo-EM structure of an Escherichia coli coupled transcription-translation complex B3 (TTC-B3) containing an mRNA with a 30 nt long spacer, transcription factors NusA and NusG, and fMet-tRNAs at P-site and E-site; E-site and P-site tRNA (fMet) 6xdq B 76 3.7 RF00005 URS000080DFF5_562 32820061 0030533 0006412 562 cgcgggguggagcagccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<........>>>>.<<<<.........>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((........)))).(((...........))).....(((((.......)))))))))))..... Cryo-EM structure of an Escherichia coli coupled transcription-translation complex B3 (TTC-B3) containing an mRNA with a 30 nt long spacer, transcription factors NusA and NusG, and fMet-tRNAs at P-site and E-site; E-site and P-site tRNA (fMet) 6xdq D 1524 3.7 RF00177,RF01959,RF01960 URS00000ABFE9_562 32820061 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccggccagcagcccgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgauaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgccguacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgaacaagguaaccguaggggccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<......>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>..<<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>>.<<<<<(((...<<<<<.......)))........>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<......>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<......<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>..>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>......<<..<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>....>>........<<<<<<<<<..>>>>>>>>>...... ........((((..[.[[[[.)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((........))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..........)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((((.......)))))))).....)....)))))....)..((((([[[...(((((....(..]]]).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))..]]]].](((((.(((((((.((..(((((..((((((((((......((......))..........(((((((..(...((.((((..(((.(((....))).))).............))))..))).((.(.(...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..(..((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))....)...)..)..(((((((((..)))))))))}..... Cryo-EM structure of an Escherichia coli coupled transcription-translation complex B3 (TTC-B3) containing an mRNA with a 30 nt long spacer, transcription factors NusA and NusG, and fMet-tRNAs at P-site and E-site; 16S rRNA 6xdq a 2880 3.7 RF02540,RF02541 URS0000B21DEA_562 32820061 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaacccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcggggcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacgguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccucccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccgaacaaacgguccuaagguagcgaaauccuugucggguaaguuccgacugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugagaugcaguguacccgcggcaagacggaaagaccccguaaccuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgggauaacaggcgauaccgcccaagaguucauaucgacggcgguguuuggcacucggucggcucaucacauccuggggcugaaguaggucccaaggguauggcguucgccauuuaaagugguacgcgagcggguuuagaacgucgugagacagucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<.<....<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>..>>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>>.>>...............<<....>>....>>.........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<.....>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>>.>>...>>>>>>>.>...<<<<<<<<<.......>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....[[[...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<.....>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>.>......>>>>>>>>..>>>>..<<<<......>>>>.........<..........<<<<<<.....>>>>>>....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<.......>>>>>..<<<<<<<<.<<<.<<......<.<<..<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<..<<.......<<<<<<<<....>>>>>>>>....>>............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>..............>>>....>>>........<<...<<<<<<...<<.......>>...>>>>>>.....>>......<<.<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<....>>>>>.....>>>>>..>...>>.>>....<.<<<<<....>>>.>>>....>>..>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]].>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((.(.....)).)))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((..(.........)...))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((.......)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(.((..(((..((((.......))))..))).....(..(((......))))..)).)...)))..))))).))...........]]].)...))))))))))...)))))))(((((..((....))..)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((.(((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....)))).)))))).))).))).....((.....)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.((..(((((((..(((........(((((..((....))...)))))........))))))))..))))....((......))...........((.........(((((.......))))).)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((....]}.)))))..((((((((.(((.((......(.((.((((..(((((.(((.(((((.(((((((((((.(.((.(..........(((...(((.......(((((((....)))))))....))).............))).).)).).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((.....[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}.......)))..).)))......(.((.(.((((((...((.......))...))))))...).))..)....(.((.((((((..(((((((((......))))))..))).(((((....))))).....)))))..)...)).).....(.(((((....))).)))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((.(....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Cryo-EM structure of an Escherichia coli coupled transcription-translation complex B3 (TTC-B3) containing an mRNA with a 30 nt long spacer, transcription factors NusA and NusG, and fMet-tRNAs at P-site and E-site; 23S rRNA 6xdq d 120 3.7 RF00001 URS0000049E57_562 32820061 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. .(((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))).. Cryo-EM structure of an Escherichia coli coupled transcription-translation complex B3 (TTC-B3) containing an mRNA with a 30 nt long spacer, transcription factors NusA and NusG, and fMet-tRNAs at P-site and E-site; 5S rRNA 6xdr 7 34 4.7 32820061 32630 auguuuuuuuuuuuuuuuuuuuuuuggugagagg .................................. .................................. Escherichia coli transcription-translation complex B (TTC-B) containing an 27 nt long mRNA spacer, NusG, and fMet-tRNAs at E-site and P-site; mRNA with 27 nt long spacer 6xdr A 76 4.7 RF00005 URS000080DFF5_562 32820061 0030533 0006412 562 cgcgggguggagcagccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((........)))).(((((.......))))).....(((((.......)))))))))))..... Escherichia coli transcription-translation complex B (TTC-B) containing an 27 nt long mRNA spacer, NusG, and fMet-tRNAs at E-site and P-site; E-site and P-site tRNA (fMet) 6xdr B 76 4.7 RF00005 URS000080DFF5_562 32820061 0030533 0006412 562 cgcgggguggagcagccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<........>>>>.<<<<.........>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((........)))).(((...........))).....(((((.......)))))))))))..... Escherichia coli transcription-translation complex B (TTC-B) containing an 27 nt long mRNA spacer, NusG, and fMet-tRNAs at E-site and P-site; E-site and P-site tRNA (fMet) 6xdr D 1524 4.7 RF00177,RF01959,RF01960 URS00000ABFE9_562 32820061 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccggccagcagcccgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgauaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgccguacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgaacaagguaaccguaggggccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<......>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>..<<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>>.<<<<<(((...<<<<<.......)))........>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<......>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<......<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>..>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>......<<..<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>....>>........<<<<<<<<<..>>>>>>>>>...... ........((((..[.[[[[.)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((........))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..........)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((((.......)))))))).....)....)))))....)..((((([[[...(((((....(..]]]).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))..]]]].](((((.(((((((.((..(((((..((((((((((......((......))..........(((((((..(...((.((((..(((.(((....))).))).............))))..))).((.(.(...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..(..((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))....)...)..)..(((((((((..)))))))))}..... Escherichia coli transcription-translation complex B (TTC-B) containing an 27 nt long mRNA spacer, NusG, and fMet-tRNAs at E-site and P-site; 16S rRNA 6xdr a 2880 4.7 RF02540,RF02541 URS0000B21DEA_562 32820061 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaacccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcggggcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacgguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccucccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccgaacaaacgguccuaagguagcgaaauccuugucggguaaguuccgacugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugagaugcaguguacccgcggcaagacggaaagaccccguaaccuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgggauaacaggcgauaccgcccaagaguucauaucgacggcgguguuuggcacucggucggcucaucacauccuggggcugaaguaggucccaaggguauggcguucgccauuuaaagugguacgcgagcggguuuagaacgucgugagacagucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<.<....<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>..>>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>>.>>...............<<....>>....>>.........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<.....>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>>.>>...>>>>>>>.>...<<<<<<<<<.......>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....[[[...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<.....>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>.>......>>>>>>>>..>>>>..<<<<......>>>>.........<..........<<<<<<.....>>>>>>....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<.......>>>>>..<<<<<<<<.<<<.<<......<.<<..<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<..<<.......<<<<<<<<....>>>>>>>>....>>............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>..............>>>....>>>........<<...<<<<<<...<<.......>>...>>>>>>.....>>......<<.<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<....>>>>>.....>>>>>..>...>>.>>....<.<<<<<....>>>.>>>....>>..>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]].>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((.(.....)).)))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((..(.........)...))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((.......)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(.((..(((..((((.......))))..))).....(..(((......))))..)).)...)))..))))).))...........]]].)...))))))))))...)))))))(((((..((....))..)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((.(((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....)))).)))))).))).))).....((.....)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.((..(((((((..(((........(((((..((....))...)))))........))))))))..))))....((......))...........((.........(((((.......))))).)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((....]}.)))))..((((((((.(((.((......(.((.((((..(((((.(((.(((((.(((((((((((.(.((.(..........(((...(((.......(((((((....)))))))....))).............))).).)).).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((.....[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}.......)))..).)))......(.((.(.((((((...((.......))...))))))...).))..)....(.((.((((((..(((((((((......))))))..))).(((((....))))).....)))))..)...)).).....(.(((((....))).)))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((.(....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Escherichia coli transcription-translation complex B (TTC-B) containing an 27 nt long mRNA spacer, NusG, and fMet-tRNAs at E-site and P-site; 23S rRNA 6xdr d 120 4.7 RF00001 URS0000049E57_562 32820061 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. .(((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))).. Escherichia coli transcription-translation complex B (TTC-B) containing an 27 nt long mRNA spacer, NusG, and fMet-tRNAs at E-site and P-site; 5S rRNA 6xez P 34 3.5 URS00021ED921_2697049 32783916,32676607,32676607 2697049 gcguagcaugcuacgucauucuccuaagaagcua .................................. .................................. Structure of SARS-CoV-2 replication-transcription complex bound to nsp13 helicase - nsp13(2)-RTC; Product RNA 6xez T 36 3.5 URS00021ED933_2697049 32783916,32676607,32676607 2697049 aauagcuucuuaggagaaugacguagcaugcuacgc .................................... .................................... Structure of SARS-CoV-2 replication-transcription complex bound to nsp13 helicase - nsp13(2)-RTC; Template RNA 6xgf 7 34 5.0 32820061 32630 auguuuuuuuuuuuuuuuuuuuuuuggugagagg .................................. .................................. Escherichia coli transcription-translation complex B (TTC-B) containing an 30 nt long mRNA spacer, NusG, and fMet-tRNAs at E-site and P-site; mRNA with 30 nt long spacer 6xgf A 76 5.0 RF00005 URS000080DFF5_562 32820061 0030533 0006412 562 cgcgggguggagcagccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((........)))).(((((.......))))).....(((((.......)))))))))))..... Escherichia coli transcription-translation complex B (TTC-B) containing an 30 nt long mRNA spacer, NusG, and fMet-tRNAs at E-site and P-site; E-site and P-site tRNA (fMet) 6xgf B 76 5.0 RF00005 URS000080DFF5_562 32820061 0030533 0006412 562 cgcgggguggagcagccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<........>>>>.<<<<.........>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((........)))).(((...........))).....(((((.......)))))))))))..... Escherichia coli transcription-translation complex B (TTC-B) containing an 30 nt long mRNA spacer, NusG, and fMet-tRNAs at E-site and P-site; E-site and P-site tRNA (fMet) 6xgf D 1524 5.0 RF00177,RF01959,RF01960 URS00000ABFE9_562 32820061 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccggccagcagcccgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgauaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgccguacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgaacaagguaaccguaggggccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<......>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>..<<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>>.<<<<<(((...<<<<<.......)))........>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<......>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<......<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>..>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>......<<..<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>....>>........<<<<<<<<<..>>>>>>>>>...... ........((((..[.[[[[.)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((........))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..........)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((((.......)))))))).....)....)))))....)..((((([[[...(((((....(..]]]).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))..]]]].](((((.(((((((.((..(((((..((((((((((......((......))..........(((((((..(...((.((((..(((.(((....))).))).............))))..))).((.(.(...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..(..((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))....)...)..)..(((((((((..)))))))))}..... Escherichia coli transcription-translation complex B (TTC-B) containing an 30 nt long mRNA spacer, NusG, and fMet-tRNAs at E-site and P-site; 16S rRNA 6xgf a 2880 5.0 RF02540,RF02541 URS0000B21DEA_562 32820061 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaacccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcggggcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacgguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccucccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccgaacaaacgguccuaagguagcgaaauccuugucggguaaguuccgacugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugagaugcaguguacccgcggcaagacggaaagaccccguaaccuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgggauaacaggcgauaccgcccaagaguucauaucgacggcgguguuuggcacucggucggcucaucacauccuggggcugaaguaggucccaaggguauggcguucgccauuuaaagugguacgcgagcggguuuagaacgucgugagacagucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<.<....<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>..>>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>>.>>...............<<....>>....>>.........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<.....>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>>.>>...>>>>>>>.>...<<<<<<<<<.......>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....[[[...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<.....>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>.>......>>>>>>>>..>>>>..<<<<......>>>>.........<..........<<<<<<.....>>>>>>....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<.......>>>>>..<<<<<<<<.<<<.<<......<.<<..<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<..<<.......<<<<<<<<....>>>>>>>>....>>............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>..............>>>....>>>........<<...<<<<<<...<<.......>>...>>>>>>.....>>......<<.<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<....>>>>>.....>>>>>..>...>>.>>....<.<<<<<....>>>.>>>....>>..>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]].>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((.(.....)).)))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((..(.........)...))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((.......)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(.((..(((..((((.......))))..))).....(..(((......))))..)).)...)))..))))).))...........]]].)...))))))))))...)))))))(((((..((....))..)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((.(((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....)))).)))))).))).))).....((.....)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.((..(((((((..(((........(((((..((....))...)))))........))))))))..))))....((......))...........((.........(((((.......))))).)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((....]}.)))))..((((((((.(((.((......(.((.((((..(((((.(((.(((((.(((((((((((.(.((.(..........(((...(((.......(((((((....)))))))....))).............))).).)).).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((.....[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}.......)))..).)))......(.((.(.((((((...((.......))...))))))...).))..)....(.((.((((((..(((((((((......))))))..))).(((((....))))).....)))))..)...)).).....(.(((((....))).)))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((.(....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Escherichia coli transcription-translation complex B (TTC-B) containing an 30 nt long mRNA spacer, NusG, and fMet-tRNAs at E-site and P-site; 23S rRNA 6xgf d 120 5.0 RF00001 URS0000049E57_562 32820061 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. .(((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))).. Escherichia coli transcription-translation complex B (TTC-B) containing an 30 nt long mRNA spacer, NusG, and fMet-tRNAs at E-site and P-site; 5S rRNA 6xhv 1A 2871 2.4 RF02540,RF02541,RF00002 URS00001698E8_300852 33462493 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacganaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<....<<<<........>>>..>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..<<......(..>>...>>>.........<<......>>.).>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<.......<<<<.<<....>>.>>>>....>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<...>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((..(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((.(..(((..........)..)))..)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((..((.........))...))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((.(((((((((.(.........(((((..(((.......(((((((....)))))))....)))............)))))).))))))))).))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..(((...)))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the A2058-dimethylated Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A- and P-site tRNAs, and deacylated E-site tRNA at 2.40A resolution; 23S Ribosomal RNA 6xhv 1B 120 2.4 RF00001 URS000080DEE8_300852 33462493 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the A2058-dimethylated Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A- and P-site tRNAs, and deacylated E-site tRNA at 2.40A resolution; 5S Ribosomal RNA 6xhv 1a 1500 2.4 RF00177,RF01959,RF01960 URS000080DFED_300852 33462493 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>.<..<<......>>.>.>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((((((....))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((..((((....))))..))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((.(((....))).)))....((......))....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the A2058-dimethylated Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A- and P-site tRNAs, and deacylated E-site tRNA at 2.40A resolution; 16S Ribosomal RNA 6xhv 1v 13 2.4 33462493 10665 aaaaauguucuaa ............. ............. Crystal structure of the A2058-dimethylated Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A- and P-site tRNAs, and deacylated E-site tRNA at 2.40A resolution; mRNA 6xhv 1w 74 2.4 RF00005 URS00005AA258_562 33462493 0030533 0006412 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcaccn <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[..)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of the A2058-dimethylated Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A- and P-site tRNAs, and deacylated E-site tRNA at 2.40A resolution; A-site tRNA 6xhv 1x 76 2.4 RF00005 URS000041AF00_562 33462493 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaaccn <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the A2058-dimethylated Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A- and P-site tRNAs, and deacylated E-site tRNA at 2.40A resolution; P-site tRNA 6xhv 1y 74 2.4 RF00005 URS00005AA258_562 33462493 0030533 0006412 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[..)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of the A2058-dimethylated Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A- and P-site tRNAs, and deacylated E-site tRNA at 2.40A resolution; E-site tRNA 6xhv 2A 2800 2.4 RF02540,RF02541,RF00002 URS00001698E8_300852 33462493 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacganaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<....<<<.<......>.>>.>....>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<..>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<...........<<<<<<<<....>>>>>>>>..................>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...((((((((.....))))))))....{.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).))))....(((((((((.[.....)))))))))....}.(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....(..)....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((.(..(.(..........)..).)..)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((.().)))))))).))..........]]].)....))))))))))...)))))))(((((((..)))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((.(((((((((.(......[..(((((...((.......(((((((....)))))))....))...........].)))))).))))))))).))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..((((((((........)))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.(...)......(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal structure of the A2058-dimethylated Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A- and P-site tRNAs, and deacylated E-site tRNA at 2.40A resolution; 23S Ribosomal RNA 6xhv 2B 120 2.4 RF00001 URS000080DEE8_300852 33462493 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>>. ..(((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).))))))))).. Crystal structure of the A2058-dimethylated Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A- and P-site tRNAs, and deacylated E-site tRNA at 2.40A resolution; 5S Ribosomal RNA 6xhv 2a 1503 2.4 RF00177,RF01959,RF01960 URS000080DFED_300852 33462493 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggau .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<...<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>...>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<......>>....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((.(((((..))))).)))).)))))......(((......((((((((..((...(((((((.(((((....((((.(....).)))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((((((....)))))))....(.(....).)....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.(.((....)).)).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}... Crystal structure of the A2058-dimethylated Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A- and P-site tRNAs, and deacylated E-site tRNA at 2.40A resolution; 16S Ribosomal RNA 6xhv 2v 13 2.4 33462493 10665 aaaaauguucuaa ............. ............. Crystal structure of the A2058-dimethylated Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A- and P-site tRNAs, and deacylated E-site tRNA at 2.40A resolution; mRNA 6xhv 2w 72 2.4 RF00005 URS00005AA258_562 33462493 0030533 0006412 562 cccgganagcucagggagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcaccn <<<<<<..<<<<.....>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((...[.)))).((((.........)))).....(((((..]....)))))))))))..... Crystal structure of the A2058-dimethylated Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A- and P-site tRNAs, and deacylated E-site tRNA at 2.40A resolution; A-site tRNA 6xhv 2x 76 2.4 RF00005 URS000041AF00_562 33462493 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaaccn <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the A2058-dimethylated Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A- and P-site tRNAs, and deacylated E-site tRNA at 2.40A resolution; P-site tRNA 6xhv 2y 73 2.4 RF00005 URS00005AA258_562 33462493 0030533 0006412 562 gcccgganagcucagggagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<.....>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[.)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of the A2058-dimethylated Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A- and P-site tRNAs, and deacylated E-site tRNA at 2.40A resolution; E-site tRNA 6xhw 1A 2871 2.5 RF02540,RF02541,RF00002 URS00001698E8_300852 33462493 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<....<<<<........>>>..>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..<<......(..>>...>>>.........<<......>>.).>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<.......<<<<<<......>>>>>>....>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<...>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (.(......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((..(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((.(..(((..........)..)))..)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((..((..((.........))...))......(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((..((((((((.(.........(((((..(((.......(((((((....)))))))....)))............)))))).))))))))..))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..(((...)))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....).) Crystal structure of the A2058-unmethylated Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A- and P-site tRNAs, and deacylated E-site tRNA at 2.50A resolution; 23S Ribosomal RNA 6xhw 1B 120 2.5 RF00001 URS000080DEE8_300852 33462493 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the A2058-unmethylated Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A- and P-site tRNAs, and deacylated E-site tRNA at 2.50A resolution; 5S Ribosomal RNA 6xhw 1a 1500 2.5 RF00177,RF01959,RF01960 URS000080DFED_300852 33462493 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<......>>....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((..)))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((.(((....))).)))....(((....)))....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the A2058-unmethylated Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A- and P-site tRNAs, and deacylated E-site tRNA at 2.50A resolution; 16S Ribosomal RNA 6xhw 1v 13 2.5 33462493 10665 aaaaauguucuaa ............. ............. Crystal structure of the A2058-unmethylated Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A- and P-site tRNAs, and deacylated E-site tRNA at 2.50A resolution; mRNA 6xhw 1w 74 2.5 RF00005 URS00005AA258_562 33462493 0030533 0006412 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcaccn <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[..)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of the A2058-unmethylated Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A- and P-site tRNAs, and deacylated E-site tRNA at 2.50A resolution; A-site tRNA 6xhw 1x 76 2.5 RF00005 URS000041AF00_562 33462493 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaaccn <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the A2058-unmethylated Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A- and P-site tRNAs, and deacylated E-site tRNA at 2.50A resolution; P-site tRNA 6xhw 1y 74 2.5 RF00005 URS00005AA258_562 33462493 0030533 0006412 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((......)))).((((.........)))).....((.((.......)).))))))))).... Crystal structure of the A2058-unmethylated Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A- and P-site tRNAs, and deacylated E-site tRNA at 2.50A resolution; E-site tRNA 6xhw 2A 2800 2.5 RF02540,RF02541,RF00002 URS00001698E8_300852 33462493 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>....<<<<<.....<......>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<..........>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<..>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<.......<<<<<<<<....>>>>>>>>....>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....(())....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...((((((((....(((..........)).)....))))))))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((.().)))))))).))..........]]].)....))))))))))...)))))))(((((((..)))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((.((.((((((.(......[..(((((...((.......((((.((....)).))))....))...........].)))))).)))))).)).))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..((((((((........)))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....))))))).............(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the A2058-unmethylated Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A- and P-site tRNAs, and deacylated E-site tRNA at 2.50A resolution; 23S Ribosomal RNA 6xhw 2B 120 2.5 RF00001 URS000080DEE8_300852 33462493 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>>. .((((((((((....((((((.(....(((((((...(.....)...))))..)))...).)))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the A2058-unmethylated Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A- and P-site tRNAs, and deacylated E-site tRNA at 2.50A resolution; 5S Ribosomal RNA 6xhw 2a 1503 2.5 RF00177,RF01959,RF01960 URS000080DFED_300852 33462493 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggau .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<.<<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<......>>....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((.(....).)))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((((((....)))))))....(.(....).)....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}... Crystal structure of the A2058-unmethylated Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A- and P-site tRNAs, and deacylated E-site tRNA at 2.50A resolution; 16S Ribosomal RNA 6xhw 2v 13 2.5 33462493 10665 aaaaauguucuaa ............. ............. Crystal structure of the A2058-unmethylated Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A- and P-site tRNAs, and deacylated E-site tRNA at 2.50A resolution; mRNA 6xhw 2w 72 2.5 RF00005 URS00005AA258_562 33462493 0030533 0006412 562 cccgganagcucagggagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcaccn <<<<<<..<<<<.....>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((...[.)))).((((.........)))).....(((((..]....)))))))))))..... Crystal structure of the A2058-unmethylated Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A- and P-site tRNAs, and deacylated E-site tRNA at 2.50A resolution; A-site tRNA 6xhw 2x 76 2.5 RF00005 URS000041AF00_562 33462493 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaaccn <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the A2058-unmethylated Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A- and P-site tRNAs, and deacylated E-site tRNA at 2.50A resolution; P-site tRNA 6xhw 2y 73 2.5 RF00005 URS00005AA258_562 33462493 0030533 0006412 562 gcccgganagcucagggagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<.....>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[.)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of the A2058-unmethylated Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A- and P-site tRNAs, and deacylated E-site tRNA at 2.50A resolution; E-site tRNA 6xhx 1A 2872 2.55 RF02540,RF02541,RF00002 URS00001698E8_300852 33462493 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>....<<<<<.....<<....>>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<......>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((...((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....((((((((..[......))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...((((((((.(.((((((......)))).)))..))))))))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((...(...........)...))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((.((((((.(.........(((((..(((......(((((.((....)).)))))...)))............)))))).)))))).)))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((.))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal structure of the A2058-unmethylated Thermus thermophilus 70S ribosome in complex with erythromycin and protein Y (YfiA) at 2.55A resolution; 23S Ribosomal RNA 6xhx 1B 120 2.55 RF00001 URS000080DEE8_300852 33462493 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>>. .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the A2058-unmethylated Thermus thermophilus 70S ribosome in complex with erythromycin and protein Y (YfiA) at 2.55A resolution; 5S Ribosomal RNA 6xhx 1a 1500 2.55 RF00177,RF01959,RF01960 URS000080DFED_300852 33462493 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<..........>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((..)))))))).)))))......(((......((((((((..((...(((((((.(((((.....(((((....)))))......)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((...(((((((....)))))))...((((....))))...)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the A2058-unmethylated Thermus thermophilus 70S ribosome in complex with erythromycin and protein Y (YfiA) at 2.55A resolution; 16S Ribosomal RNA 6xhx 2A 2867 2.55 RF02540,RF02541,RF00002 URS00001698E8_300852 33462493 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>....<<<<<.....<......>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<.<.<<<<<<......>>>>.>>>..>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<.........>>....>>......................>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<..>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<.<<<<<......>>>>>>....>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...((((((((.....))))))))....{.(((((((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).))))....(((((((((.[.....)))))))))....}.(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((()))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((...((((((......)))).))...)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((........((((.((...(((.......)))....)).........((......))...))))....)))))))))).))..........]]].)....))))))))))...)))))))(((((((())))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((.((((((.(......[..(((((..(((.......((((.((....)).))))....)))..........].)))))).)))))).)))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.((.))......(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal structure of the A2058-unmethylated Thermus thermophilus 70S ribosome in complex with erythromycin and protein Y (YfiA) at 2.55A resolution; 23S Ribosomal RNA 6xhx 2B 120 2.55 RF00001 URS000080DEE8_300852 33462493 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the A2058-unmethylated Thermus thermophilus 70S ribosome in complex with erythromycin and protein Y (YfiA) at 2.55A resolution; 5S Ribosomal RNA 6xhx 2a 1504 2.55 RF00177,RF01959,RF01960 URS000080DFED_300852 33462493 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>.....<......>....>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(.((((((((..)))))))).).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((((((....))))))).(..(((....)))..).)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the A2058-unmethylated Thermus thermophilus 70S ribosome in complex with erythromycin and protein Y (YfiA) at 2.55A resolution; 16S Ribosomal RNA 6xhy 1A 2871 2.6 RF02540,RF02541,RF00002 URS00001698E8_300852 33462493 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<.....<<<........>>>......>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..<<.........>>...>>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<.......<<<<<<......>>>>>>....>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<...>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((..(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((.(..(((..........))..))..)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((..((.........))...))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((..((((((((.(......[..(((((..(.(.......((((.((....)).))))....).)..........].)))))).))))))))..))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..(((...)))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with telithromycin, mRNA, aminoacylated A- and P-site tRNAs, and deacylated E-site tRNA at 2.60A resolution; 23S Ribosomal RNA 6xhy 1B 120 2.6 RF00001 URS000080DEE8_300852 33462493 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> (((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).))))))))))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with telithromycin, mRNA, aminoacylated A- and P-site tRNAs, and deacylated E-site tRNA at 2.60A resolution; 5S Ribosomal RNA 6xhy 1a 1500 2.6 RF00177,RF01959,RF01960 URS000080DFED_300852 33462493 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<......>>....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((..)))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((.(((....))).)))....(((....)))....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the Thermus thermophilus 70S ribosome in complex with telithromycin, mRNA, aminoacylated A- and P-site tRNAs, and deacylated E-site tRNA at 2.60A resolution; 16S Ribosomal RNA 6xhy 1v 13 2.6 33462493 10665 aaaaauguucuaa ............. ............. Crystal structure of the Thermus thermophilus 70S ribosome in complex with telithromycin, mRNA, aminoacylated A- and P-site tRNAs, and deacylated E-site tRNA at 2.60A resolution; mRNA 6xhy 1w 74 2.6 RF00005 URS00005AA258_562 33462493 0030533 0006412 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcaccn <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[..)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with telithromycin, mRNA, aminoacylated A- and P-site tRNAs, and deacylated E-site tRNA at 2.60A resolution; A-site tRNA 6xhy 1x 76 2.6 RF00005 URS000041AF00_562 33462493 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaaccn <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with telithromycin, mRNA, aminoacylated A- and P-site tRNAs, and deacylated E-site tRNA at 2.60A resolution; P-site tRNA 6xhy 1y 74 2.6 RF00005 URS00005AA258_562 33462493 0030533 0006412 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((......)))).((((.........)))).....((.((.......)).))))))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with telithromycin, mRNA, aminoacylated A- and P-site tRNAs, and deacylated E-site tRNA at 2.60A resolution; E-site tRNA 6xhy 2A 2800 2.6 RF02540,RF02541,RF00002 URS00001698E8_300852 33462493 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>....<<<<<.....<......>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<....<<............>.>....>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<..>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<..>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<.......<<<<<<<<....>>>>>>>>....>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....(..)....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((....(((..........)).)....)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((.().)))))))).))..........]]].)....))))))))))...)))))))(((((((())))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(......[..(((((..(((.......(((((((....)))))))....)))..........].)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....))))))).((...)).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with telithromycin, mRNA, aminoacylated A- and P-site tRNAs, and deacylated E-site tRNA at 2.60A resolution; 23S Ribosomal RNA 6xhy 2B 120 2.6 RF00001 URS000080DEE8_300852 33462493 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>. .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the Thermus thermophilus 70S ribosome in complex with telithromycin, mRNA, aminoacylated A- and P-site tRNAs, and deacylated E-site tRNA at 2.60A resolution; 5S Ribosomal RNA 6xhy 2a 1503 2.6 RF00177,RF01959,RF01960 URS000080DFED_300852 33462493 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggau .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<......>>....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<..<.<<<<<<<........>>>>>>>>...>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((((((....)))))))....(.(....).)....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}... Crystal structure of the Thermus thermophilus 70S ribosome in complex with telithromycin, mRNA, aminoacylated A- and P-site tRNAs, and deacylated E-site tRNA at 2.60A resolution; 16S Ribosomal RNA 6xhy 2v 13 2.6 33462493 10665 aaaaauguucuaa ............. ............. Crystal structure of the Thermus thermophilus 70S ribosome in complex with telithromycin, mRNA, aminoacylated A- and P-site tRNAs, and deacylated E-site tRNA at 2.60A resolution; mRNA 6xhy 2w 72 2.6 RF00005 URS00005AA258_562 33462493 0030533 0006412 562 cccgganagcucagggagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcaccn <<<<<<..<<<<.....>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((...[.)))).((((.........)))).....(((((..]....)))))))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with telithromycin, mRNA, aminoacylated A- and P-site tRNAs, and deacylated E-site tRNA at 2.60A resolution; A-site tRNA 6xhy 2x 76 2.6 RF00005 URS000041AF00_562 33462493 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaaccn <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with telithromycin, mRNA, aminoacylated A- and P-site tRNAs, and deacylated E-site tRNA at 2.60A resolution; P-site tRNA 6xhy 2y 73 2.6 RF00005 URS00005AA258_562 33462493 0030533 0006412 562 gcccgganagcucagggagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<.....>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[.)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with telithromycin, mRNA, aminoacylated A- and P-site tRNAs, and deacylated E-site tRNA at 2.60A resolution; E-site tRNA 6xii 7 31 7.0 32820061 32630 auguuuuuuuuuuuuuuuuuuuggugagagg ............................... ............................... Escherichia coli transcription-translation complex B (TTC-B) containing an 24 nt long mRNA spacer, NusG, and fMet-tRNAs at E-site and P-site; mRNA with 24 nt long spacer 6xii A 76 7.0 RF00005 URS000080DFF5_562 32820061 0030533 0006412 562 cgcgggguggagcagccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((........)))).(((((.......))))).....(((((.......)))))))))))..... Escherichia coli transcription-translation complex B (TTC-B) containing an 24 nt long mRNA spacer, NusG, and fMet-tRNAs at E-site and P-site; E-site and P-site tRNA (fMet) 6xii B 76 7.0 RF00005 URS000080DFF5_562 32820061 0030533 0006412 562 cgcgggguggagcagccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<........>>>>.<<<<.........>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((........)))).(((...........))).....(((((.......)))))))))))..... Escherichia coli transcription-translation complex B (TTC-B) containing an 24 nt long mRNA spacer, NusG, and fMet-tRNAs at E-site and P-site; E-site and P-site tRNA (fMet) 6xii D 1524 7.0 RF00177,RF01959,RF01960 URS00000ABFE9_562 32820061 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccggccagcagcccgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgauaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgccguacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgaacaagguaaccguaggggccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<......>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>..<<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>>.<<<<<(((...<<<<<.......)))........>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<......>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<......<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>..>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>......<<..<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>....>>........<<<<<<<<<..>>>>>>>>>...... ........((((..[.[[[[.)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((........))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..........)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((((.......)))))))).....)....)))))....)..((((([[[...(((((....(..]]]).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))..]]]].](((((.(((((((.((..(((((..((((((((((......((......))..........(((((((..(...((.((((..(((.(((....))).))).............))))..))).((.(.(...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..(..((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))....)...)..)..(((((((((..)))))))))}..... Escherichia coli transcription-translation complex B (TTC-B) containing an 24 nt long mRNA spacer, NusG, and fMet-tRNAs at E-site and P-site; 16S rRNA 6xii a 2880 7.0 RF02540,RF02541 URS0000B21DEA_562 32820061 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaacccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcggggcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacgguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccucccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccgaacaaacgguccuaagguagcgaaauccuugucggguaaguuccgacugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugagaugcaguguacccgcggcaagacggaaagaccccguaaccuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgggauaacaggcgauaccgcccaagaguucauaucgacggcgguguuuggcacucggucggcucaucacauccuggggcugaaguaggucccaaggguauggcguucgccauuuaaagugguacgcgagcggguuuagaacgucgugagacagucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<.<....<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>..>>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>>.>>...............<<....>>....>>.........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<.....>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>>.>>...>>>>>>>.>...<<<<<<<<<.......>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....[[[...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<.....>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>.>......>>>>>>>>..>>>>..<<<<......>>>>.........<..........<<<<<<.....>>>>>>....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<.......>>>>>..<<<<<<<<.<<<.<<......<.<<..<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<..<<.......<<<<<<<<....>>>>>>>>....>>............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>..............>>>....>>>........<<...<<<<<<...<<.......>>...>>>>>>.....>>......<<.<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<....>>>>>.....>>>>>..>...>>.>>....<.<<<<<....>>>.>>>....>>..>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]].>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((.(.....)).)))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((..(.........)...))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((.......)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(.((..(((..((((.......))))..))).....(..(((......))))..)).)...)))..))))).))...........]]].)...))))))))))...)))))))(((((..((....))..)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((.(((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....)))).)))))).))).))).....((.....)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.((..(((((((..(((........(((((..((....))...)))))........))))))))..))))....((......))...........((.........(((((.......))))).)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((....]}.)))))..((((((((.(((.((......(.((.((((..(((((.(((.(((((.(((((((((((.(.((.(..........(((...(((.......(((((((....)))))))....))).............))).).)).).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((.....[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}.......)))..).)))......(.((.(.((((((...((.......))...))))))...).))..)....(.((.((((((..(((((((((......))))))..))).(((((....))))).....)))))..)...)).).....(.(((((....))).)))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((.(....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Escherichia coli transcription-translation complex B (TTC-B) containing an 24 nt long mRNA spacer, NusG, and fMet-tRNAs at E-site and P-site; 23S rRNA 6xii d 120 7.0 RF00001 URS0000049E57_562 32820061 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. .(((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))).. Escherichia coli transcription-translation complex B (TTC-B) containing an 24 nt long mRNA spacer, NusG, and fMet-tRNAs at E-site and P-site; 5S rRNA 6xij 7 22 8.0 32820061 32630 auguuuuuuuuuuggugagagg ...................... ...................... Escherichia coli transcription-translation complex A (TTC-A) containing an 24 nt long mRNA spacer, NusG, and fMet-tRNAs at E-site and P-site; mRNA with 24 nt long spacer 6xij A 76 8.0 RF00005 URS000080DFF5_562 32820061 0030533 0006412 562 cgcgggguggagcagccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((........)))).(((((.......))))).....(((((.......)))))))))))..... Escherichia coli transcription-translation complex A (TTC-A) containing an 24 nt long mRNA spacer, NusG, and fMet-tRNAs at E-site and P-site; E-site and P-site tRNA (fMet) 6xij B 76 8.0 RF00005 URS000080DFF5_562 32820061 0030533 0006412 562 cgcgggguggagcagccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<........>>>>.<<<<.........>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((........)))).(((...........))).....(((((.......)))))))))))..... Escherichia coli transcription-translation complex A (TTC-A) containing an 24 nt long mRNA spacer, NusG, and fMet-tRNAs at E-site and P-site; E-site and P-site tRNA (fMet) 6xij D 1524 8.0 RF00177,RF01959,RF01960 URS00000ABFE9_562 32820061 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccggccagcagcccgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgauaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgccguacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgaacaagguaaccguaggggccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<......>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>..<<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>>.<<<<<(((...<<<<<.......)))........>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<......>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<......<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>..>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>......<<..<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>....>>........<<<<<<<<<..>>>>>>>>>...... ........((((..[.[[[[.)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((........))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..........)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((((.......)))))))).....)....)))))....)..((((([[[...(((((....(..]]]).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))..]]]].](((((.(((((((.((..(((((..((((((((((......((......))..........(((((((..(...((.((((..(((.(((....))).))).............))))..))).((.(.(...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..(..((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))....)...)..)..(((((((((..)))))))))}..... Escherichia coli transcription-translation complex A (TTC-A) containing an 24 nt long mRNA spacer, NusG, and fMet-tRNAs at E-site and P-site; 16S rRNA 6xij a 2880 8.0 RF02540,RF02541 URS0000B21DEA_562 32820061 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaacccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcggggcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacgguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccucccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccgaacaaacgguccuaagguagcgaaauccuugucggguaaguuccgacugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugagaugcaguguacccgcggcaagacggaaagaccccguaaccuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgggauaacaggcgauaccgcccaagaguucauaucgacggcgguguuuggcacucggucggcucaucacauccuggggcugaaguaggucccaaggguauggcguucgccauuuaaagugguacgcgagcggguuuagaacgucgugagacagucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<.<....<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>..>>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>>.>>...............<<....>>....>>.........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<.....>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>>.>>...>>>>>>>.>...<<<<<<<<<.......>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....[[[...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<.....>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>.>......>>>>>>>>..>>>>..<<<<......>>>>.........<..........<<<<<<.....>>>>>>....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<.......>>>>>..<<<<<<<<.<<<.<<......<.<<..<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<..<<.......<<<<<<<<....>>>>>>>>....>>............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>..............>>>....>>>........<<...<<<<<<...<<.......>>...>>>>>>.....>>......<<.<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<....>>>>>.....>>>>>..>...>>.>>....<.<<<<<....>>>.>>>....>>..>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]].>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((.(.....)).)))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((..(.........)...))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((.......)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(.((..(((..((((.......))))..))).....(..(((......))))..)).)...)))..))))).))...........]]].)...))))))))))...)))))))(((((..((....))..)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((.(((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....)))).)))))).))).))).....((.....)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.((..(((((((..(((........(((((..((....))...)))))........))))))))..))))....((......))...........((.........(((((.......))))).)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((....]}.)))))..((((((((.(((.((......(.((.((((..(((((.(((.(((((.(((((((((((.(.((.(..........(((...(((.......(((((((....)))))))....))).............))).).)).).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((.....[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}.......)))..).)))......(.((.(.((((((...((.......))...))))))...).))..)....(.((.((((((..(((((((((......))))))..))).(((((....))))).....)))))..)...)).).....(.(((((....))).)))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((.(....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Escherichia coli transcription-translation complex A (TTC-A) containing an 24 nt long mRNA spacer, NusG, and fMet-tRNAs at E-site and P-site; 23S rRNA 6xij d 120 8.0 RF00001 URS0000049E57_562 32820061 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. .(((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))).. Escherichia coli transcription-translation complex A (TTC-A) containing an 24 nt long mRNA spacer, NusG, and fMet-tRNAs at E-site and P-site; 5S rRNA 6xiq 1 3223 4.2 RF02540,RF02543 URS000080E1A1_4932 32855298 0003735 0005840 4932 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaugguguuuuguauuucacuggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauagaggguguagaauaagugggagcuucggcgccagugaaauaccacuaccuuuauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu 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.........................((((......(...[..).......))))...........((....))....(((......((.]...)).....)))....((((..........((.((...(...)...)).)).............((((((.(((((.(..(((..(((.(.(...(.((((......)))))..(...)..((.......).)....).).)))....)))..).....)))))))))))...)....(.(..(..........)..).).....(..((...[[[[[))..)..)))..................................(......)................(((....)))....................................((((...(.(.......(..............)..(((((((.(.(..(..(.(((((.......(((((((......(((..((..))..))).......))))))).....)))))..).)...).)........(((....))).....))))))).....).)...))))..<((.(........).)).(((((....(.(.(..(((.((..(.....((((.....)))).....)...................((((..(((((....)))))...))))...((..((....((....).)...))...).).....)).)))..))..)...(((...((((.......((.((((((..........((((((....)))))).....<.......((..((.((........)))).)).....)))))).)).(.((.......))...)....))))......).))..(...((.....(.((....)))...(..(..(((...((...((((.(.....(.(.....(...(.((((.....((((.....))))...)))).)...)...)..).....).)))...((((..(((.(......))))..)))).....)..)).))).)....)...(((((.(.((.....)).)).))))....((.(.....)))...(((..((...((.[[[......(((((......(..........(((.((((((((((.......((((..(.(...((.........))....)).....(..............)..))))...)))))))))))))..........]]].)....)))))...))...))..)))(((((((((.........)))))))))....))...)(.(..(((...((.......(.....((....))....)....))..)))..)..).....))))).((.....((......(((((.......))))).(((......(.(...((.(.(((((....(.......)..)))).).....((..((...((....(((....))).........(((((((...)).)))).)....))....))....((.(........).))...((((..(((.(.....((((....))).....[[(((((....((((.(.((((((.((((((((....{{...)))))....((((.....(((((......((.....))......)))))......))))......((((((......)))))).)))..).))))).).))))(...).....)))))....)......)...))).))))..)).))).....((......)).)..).(((.......)))...)))..((((.....(((((((.((..(............((((.....(.[..)......))))((.((.(.((.((.(...))).)..).).)).))(...).......(((((((((.>.(...........)...(((((((.....(((.....))).......))))))).].(((.(((..((.(.(.(...(......(((......)))......).)).)...)))))(((((.........)))))........(.(.........(((...........)))..)..)....)))....)).)))))))....))).)))))))..))))))....)).[..(((((.....>].)))))....(.(.(..(((..(......((.(.((((.(..((((............(..(.((.((....(((..........((..(..(......)............)..)).))).....)).))..).)....(((......(((....((..........))...........]]....(((((....)))))....)))...))).................))))..(((......[)).)((((((..........]))))))([((....((((((.(.((((((.......))))))...).((][..[[))....))))))....(.((.........{........))).(((....))).))]]..]......(.(((....((.]]]]].))..))).).....)}....).))..))).))...............(((.....((.......)).....))).................(..((.(..(((..(..(((((........)))))....).(.(.(.....).).).....)))....)...))...)....(..((((....))).).).....)...))).).).)....((((((((..(((..(.((.........(....)........)).)(((((..(..(.....((((.((.((}}..)).))...))))....).)..)))))..(((...((((.............))))...)))...)))....)))))))).......(.((((.(.(.((.....(.(........(((((((..).)))))).....))........((((((.......(.(..(((......)))...)).....)))))).............)))..).)))).)..(((.(.......................(((...(........((((.(..(((.((..)..).)))..)))))..........)....)))....).))).. Cryo-EM Structure of K63R Ubiquitin Mutant Ribosome under Oxidative Stress; 35S ribosomal RNA 6xiq 3 121 4.2 RF00001 URS0000556CA5_4932 32855298 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguucuccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.........<..............>...........>>>>>>.>><<<<<<..........<<..<<....>>.>>........>>>>>>>>>>>>>>>. (((((((((....((((((((.......((((...(....)...))).)........)))))).))..((((.......(......((....)).....).....))))..))))))))). Cryo-EM Structure of K63R Ubiquitin Mutant Ribosome under Oxidative Stress; 5S ribosomal RNA 6xiq 4 158 4.2 RF00002 URS00001BF64E_4932 32855298 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .............................................<<<<<....>>>........<<<......>>..............>>>......................<<<<<<<<......>>>>>>>>..................... ..........................................((..(.[[.....).......(..((......]]..............))...)....))....(.......)((((((((......))))))))..................... Cryo-EM Structure of K63R Ubiquitin Mutant Ribosome under Oxidative Stress; 5.8S ribosomal RNA 6xiq 2 1743 4.2 RF01960,RF01959,RF00177 URS00005F2C2D_4932 32855298 0003735 0005840 4932 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucau 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...((((..[.[[[..))))((...((((((...(.(...((.....(((.(((..(.....(.......................)[.)......(((.......(((..((..((....((...................(.....((.............))......).........(((((...(.....)..)))))(....((.((......{...{.{.(((....))).....(......).).)))......).(.((((...(.(..)..)..)))))....))...))))..))).(((....((.....((((((((.......)))))))).))......)))...(((.((((....))))....))))))....(((..........)))....(.(.(...).))...)))))).).....(.(((...((((.]...))).))))).)....).).....(.(((((.(..((....).).).)))).).)....(.(.(.(...........))..)......)..((((([[....(.((((.....((..]])).......))))))))))..))))))..))..[......((([[...(.(.((...(((.((....((((((.(((((............))))).))))))....(.(.((........(.(..(....).).)........)).).)...((((..((.......((..((.......))..((.....)).....))......))..)..))).........(....((((.(((.....}.}..}..))).))))...).....))...(((..((..(...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)..))...))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..((((((((.(((...)))))))))))..)))...((..]]))...))...].))))))).(((.......(((....))).....)))...]]].](((((.(((((((..((..(((((..(.(.((((((......((........))..........(((.(.(....((((..).)))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....((((.(((..(.(...((..(..(.((......)).).....).))...).).))..(.(((((.......)))))....)..)))))....))).))).....).))))).....)..))))...)).)))).).).(...(((((((......((......((.(..(....)..)..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(....(..(..((((.((..(.(((((((..(((..(.((..(...(((((...((.....(.....)......))...)))))...)..)).)..)))..))))))))..)).))))...)..)......)..(((((((((....)))))))))}...... Cryo-EM Structure of K63R Ubiquitin Mutant Ribosome under Oxidative Stress; 18S ribosomal RNA 6xiq AX 76 4.2 RF00005 URS000011107D_4932 32855298 0030533 0006412 4932 gcggauuuagcucaguugggagagcgccagacugaagaucuggagguccuguguucgauccacagaauucgcacca <<.......<<<<........>>>>..<.<<.......>>.>......<<<<<.......>>>>>.....>>.... (((..(...((((.....[..)))).((.(.........).)).....(((((..]....))))).)..))).... Cryo-EM Structure of K63R Ubiquitin Mutant Ribosome under Oxidative Stress; Transfer RNA 6xiq AZ 76 4.2 RF00005 URS000011107D_4932 32855298 0030533 0006412 4932 gcggauuuagcucaguugggagagcgccagacugaagaucuggagguccuguguucgauccacagaauucgcacca <<...<...<<<<........>>>>..<<<<.......>>>>......<<<<<.......>>>>>.>...>>.... (((.((...((((.....[..)))).((((.........)))).....(((((..]....))))).)).))).... Cryo-EM Structure of K63R Ubiquitin Mutant Ribosome under Oxidative Stress; Transfer RNA 6xir 1 3113 3.2 RF02540,RF02543 URS000080E1A1_4932 32855298 0003735 0005840 4932 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaugguguuuuguauuucacuggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagcccaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagaucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu .........................<<<<<.....<......>......>>>>>...........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<.<<<...<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>>..>>>>>>......>.>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<<........................<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<.......<<..........>>........>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<..............>>>.>>>.>>....>>>>>>.>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<..<.<<<<....<<<<<.....>>>>>..>>>>.>..>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<......................>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><<<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>.>>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<<<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<<....>>>>>>>>>>>>.>.>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<................>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<..<<<....<<<<<....>>>>.>...>>>>>>>>..>>>>><<<<<.........>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<..>>>>>>>...<<<<<.....<<<<...................................................>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>..>>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<.............>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<.........<..<<<......>>>..>.......>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<.<..<<<<........>>>>..>>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((..(......(((.((((((...)))))).))....)...)....((((.(...(.(.((((((.((((((((...({((((......)))))[[(...).(((....}]])))....))))))))...)))))).....))...).))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((......(..............)..(((((((((((((((((((((((.......(((((((........(..((..))..).........))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).<((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((..............))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))..).))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.(((.(....((((.....))))...)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.(((((((((......{.(.(....).)....))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...((((((...((.....)).))))))....[[(((.((...((....(((....)))........((...((.....).)...))....))....))...(((((........)))))]]((((..(((((((...((((....)))...(.[[((((((...((((.(((((((((((((((((...{{{...)))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((............)..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(..((......(((......)))......)))))))..)))))(.(((.........))).)........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((..)))))))....((((.....((((..(.(...........))..........]]....((..(.....).))...))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......(..(.(..(((((...((.......))...)))))....))...)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a.))..))).)))))....((((((((..((((.(.((((((.....(....)....)))))).)(((((...((((....((((((((((}}}.)))))..)))))...))))..))))).((((...((.((....}......)).))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((.(..((.(.(..(((......)))..).).))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((.(((((.(((....((((.(..(((.((..)..).)))..)))))...)))....)))).).)))).))))).. Cryo-EM Structure of K63 Ubiquitinated Yeast Translocating Ribosome under Oxidative Stress; 35S ribosomal RNA 6xir 3 121 3.2 RF00001 URS0000556CA5_4932 32855298 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguucuccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<....<<<.<<<............>>>....>>...>>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Cryo-EM Structure of K63 Ubiquitinated Yeast Translocating Ribosome under Oxidative Stress; 5S ribosomal RNA 6xir 4 158 3.2 RF00002 URS00001BF64E_4932 32855298 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((.(((.[[.....))).....(.((((.....]]............).)))..)....))....((.....))(((((((((....)))))))))..................... Cryo-EM Structure of K63 Ubiquitinated Yeast Translocating Ribosome under Oxidative Stress; 5.8S ribosomal RNA 6xir 2 1708 3.2 RF01960,RF01959,RF00177 URS00005F2C2D_4932 32855298 0003735 0005840 4932 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggaacggggccuuuccuucuggcuaagcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucau ...<<<<<...((((>>>>><<<..<<<<<<................<<<.<<<...<....<<.....................>>.>.......<<........<<<..<<..<<......<..................<.....<...............>......>...........<.<...<....>...>.>..........<<......[.[.[.................<........>>>.............<<<<..<<<.....>>>.>>>>....>.....>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>....<....>......>>>>>>.........<<<....<<<.....>>>..>>>...............<<......<<.<<....>>..>>......>>......<<<..............>.>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<<<((.....<.<<...<<<.<<.....<<<..............>>>.......<<.<.........>.>>.....<<.....<.........................<.....>..............>.......>>..............<<..<<.........].].]...>>..>>.........>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>......<<<....>>>..>>>>..>>.>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<.....>>>>>>>>>>..>>>...<<..))>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..))))..<<<<<.<<<<<<<..<<..<<<<<..<<<..<<.<<......<<........>>..........<<.........<.<......>.>......<<......<<<<<<....<<<.<<.<<....>>....<<<......>>>...>>.>>>....<<<...<<.....<..<<<........................>>>..>....>>.....<<<<.......>>>>..........>>>....>>>.>>>........>>............>>...>>..>>..>>>.....<<<<<........<<.........<<<<....>>>>........>>........>.>>>>...........<<<<<<..........>>>>>>..........>>>>>......<<<<<<<.......>>>>>>>.......>>...>>>>>>>>>>.>>....<..<<.<..............<........<<..<.<<..................................................>>.>..>>........>..............>.>>...>.....<<.<<.<<<....>>>.>>.>>....... ...((((....[[[..))))((....(((((.........((.....(((.(((..(.....((.....(..........)....))[.)......(((.......(((..((..((.....((..................(.....(...............)......)...........(.(...(.....)..).)..(.(.((..((.......{{.{.{.(((....))).....(......).))..)).)...)...((((...(((..).))..))))....))....))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.(((......)))....)))))).((.(((..........))).)).(..(....)...)..)))))).).....(.(((...((((.]...))).))))).)............(.(...(.(..((....).).).)....).)....(.(((.(...........)).))......)...(((([[....(.((((.....((..]])).......)))))))))...)))))...))..[......((([[...(.(.((...(((.((.....(((((..........))))).......((((.........)))).....((((...(.......(................((.....))......)......)...)..))).........(....((...(........}}.}}....)...))...).....))...(((..((.((...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)).))...))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..((((((((.((.....))))))))))..)))...((..]]))...))...].)))))))..((......((.(....).))....))....]]]..(((((.(((((((..((..(((((..(((..(((((......((........))..........((.(.......(.(......).)....(.((.......(((((....(.(.(((((....)))..(.((......)))...)).).)....(((...((....((..((..(..(..(......).)......).))..))...))....(.(.(........)).).........)))....))).)).........))).........).))...)).)))..))).(...((((((.......((......(..((((....))))...)....))........)))))).......(...((((((..........))))))....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(........(.....(.(.....(((..(.((..(......((..........(.....)...........))......)..)).)..))).....).).....)........).))...)..)..((.((.(((....))).)).))}...... Cryo-EM Structure of K63 Ubiquitinated Yeast Translocating Ribosome under Oxidative Stress; 18S ribosomal RNA 6xir AX 73 3.2 RF00005 URS000011107D_4932 32855298 0030533 0006412 4932 gcggauuuagcucaguugggagagcgccagacugaagaucuggagguccuguguucgauccacagaauucgca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>. (((.(((..((((.....[..)))).(((((.......))))).....(((((..]....)))))))).))). Cryo-EM Structure of K63 Ubiquitinated Yeast Translocating Ribosome under Oxidative Stress; Transfer RNA 6xmg C 130 4.8 URS00021ED9A6_256318 33495647 256318 gggaugcuuacuuagucaucugguuggcaaaccuccgcggaccuucgggaccaauggagaggaacccagccgagaagcaucgagccgguauaccggcucugacaccaacugugauaaacuaccgcauuaa ..<<<<<<<.<<<.(((....<<<<<<....<<<<<..<<.<<....>>.>>...>>>>.>....>>>>>>>>>>>>>>>><<<<<<<<..>>>>>>>>.)))........................... ..(((((((.(((.[[[....((((((.....((((..((.((....)).))...))))......))))))))))))))))((((((((..)))))))).]]]........................... Cryo-EM structure of Cas12g ternary complex; RNA (130-MER) 6xmg E 24 4.8 URS00021ED93D_256318 33495647 256318 uuaaugcgguaguuuaucacaguu ........................ ........................ Cryo-EM structure of Cas12g ternary complex; RNA (5'-R(P*UP*UP*AP*AP*UP*GP*CP*GP*GP*UP*AP*GP*UP*UP*UP*AP*UP*CP*AP*CP*AP*GP*UP*U)-3') 6xn3 R 37 3.0 URS00023119BC_1360 35351985 1360 acgagaacauacguucuuugaaccaagcuucaacucc ..................................... ..................................... Structure of the Lactococcus lactis Csm CTR_4:3 CRISPR-Cas Complex; Crispr RNA 6xn3 T 34 3.0 URS0002311A25_1360 35351985 1360 aggaguugaagcuugguucaaagaacguaucaag .................................. .................................. Structure of the Lactococcus lactis Csm CTR_4:3 CRISPR-Cas Complex; target RNA 6xn4 R 35 3.35 URS0002311A21_1360 35351985 1360 acgagaacauacguucuuugaaccaagcuucaacu ................................... ................................... Structure of the Lactococcus lactis Csm CTR_3:2 CRISPR-Cas Complex; Crispr RNA 6xn4 T 30 3.35 URS00023119A6_1360 35351985 1360 guugaagcuugguucaaagaacguaucaag .............................. .............................. Structure of the Lactococcus lactis Csm CTR_3:2 CRISPR-Cas Complex; target RNA 6xn7 R 37 3.47 URS00023119BC_1360 35351985 1360 acgagaacauacguucuuugaaccaagcuucaacucc ..................................... ..................................... Structure of the Lactococcus lactis Csm NTR CRISPR-Cas Complex; Crispr RNA 6xn7 T 37 3.47 URS0002311A14_1360 35351985 1360 aggaguugaagcuugguucaaagaacguauguucucg ..................................... ..................................... Structure of the Lactococcus lactis Csm NTR CRISPR-Cas Complex; Target RNA 6xqd 1A 2871 2.8 RF02540,RF02541,RF00002 URS00001698E8_300852 32817463 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<..<<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<.....<<<........>>>......>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..<<<.......>>>...>>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<.<<<..>>>.>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)..)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((.(..(((..........)..)))..)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((..((.........))...))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((..((((((((.(.........(((((..(((......(((((.((....)).)))))...)))............)))))).))))))))..))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..(((...)))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with sarecycline, UUC-mRNA, and deacylated P-site tRNA at 2.80A resolution; 23S Ribosomal RNA 6xqd 1B 120 2.8 RF00001 URS000080DEE8_300852 32817463 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the Thermus thermophilus 70S ribosome in complex with sarecycline, UUC-mRNA, and deacylated P-site tRNA at 2.80A resolution; 5S Ribosomal RNA 6xqd 1a 1500 2.8 RF00177,RF01959,RF01960 URS000080DFED_300852 32817463 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<...<<<<<<......>>>>>.>...>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<......>>....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((((((....))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((..((((....))))..))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((.(((((((...))))))).))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((...(((.(((....))).)))....(((....)))....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the Thermus thermophilus 70S ribosome in complex with sarecycline, UUC-mRNA, and deacylated P-site tRNA at 2.80A resolution; 16S Ribosomal RNA 6xqd 1v 10 2.8 32817463 10665 aaaaauguuc .......... .......... Crystal structure of the Thermus thermophilus 70S ribosome in complex with sarecycline, UUC-mRNA, and deacylated P-site tRNA at 2.80A resolution; mRNA 6xqd 1x 76 2.8 RF00005 URS000041AF00_562 32817463 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with sarecycline, UUC-mRNA, and deacylated P-site tRNA at 2.80A resolution; P-site tRNA 6xqd 2A 2800 2.8 RF02540,RF02541,RF00002 URS00001698E8_300852 32817463 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>....<<<<<.....<......>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<..>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...((((((((.....))))))))....{.(((((((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).))))....(((((((((.[.....)))))))))....}.(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((()))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((.....((..........))......)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((.().)))))))).))..........]]].)....))))))))))...)))))))(((((((..)))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((....))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(......[..(((((...((......(((((.((....)).)))))...))...........].)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(((...)).....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))...)))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with sarecycline, UUC-mRNA, and deacylated P-site tRNA at 2.80A resolution; 23S Ribosomal RNA 6xqd 2B 120 2.8 RF00001 URS000080DEE8_300852 32817463 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>. ..(((((((((....((((((.(....(((((((...(.....)...))))..)))...).)))).))(((.......((((((((....)))))))).......))).))))))))).. Crystal structure of the Thermus thermophilus 70S ribosome in complex with sarecycline, UUC-mRNA, and deacylated P-site tRNA at 2.80A resolution; 5S Ribosomal RNA 6xqd 2a 1503 2.8 RF00177,RF01959,RF01960 URS000080DFED_300852 32817463 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggau .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<.<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<......>>....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>..>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((((((....)))))))....(.(....).)....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.(.((....)).)).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}... Crystal structure of the Thermus thermophilus 70S ribosome in complex with sarecycline, UUC-mRNA, and deacylated P-site tRNA at 2.80A resolution; 16S Ribosomal RNA 6xqd 2x 76 2.8 RF00005 URS000041AF00_562 32817463 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with sarecycline, UUC-mRNA, and deacylated P-site tRNA at 2.80A resolution; P-site tRNA 6xqe 1A 2871 3.0 RF02540,RF02541,RF00002 URS00001698E8_300852 32817463 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<........>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..<<.........>>...>>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<<..>>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((.((((.....)))).)))....(.(((((((((...((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((.(...(..............).)..)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((.(((.....{.(((((.(((..((.........))...))).....(...((......)).).)))))...))).)))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((..))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((.((((((((((((.(.........(((((..(((......(((((.((....)).)))))...)))............)))))).)))))))))))).)))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))(.((...(((((((.(.(((((.........)))))...).((.[.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..(((...)))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with sarecycline, UAA-mRNA, and deacylated P-site tRNA at 3.00A resolution; 23S Ribosomal RNA 6xqe 1B 120 3.0 RF00001 URS000080DEE8_300852 32817463 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> (((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).))))))))))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with sarecycline, UAA-mRNA, and deacylated P-site tRNA at 3.00A resolution; 5S Ribosomal RNA 6xqe 1a 1500 3.0 RF00177,RF01959,RF01960 URS000080DFED_300852 32817463 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<...<<<<<<......>>>>>.>...>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<.<<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<......>>....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((((((....))))))).)))))......(((......((((((((..((...((((((..(((((.....((((......))))......)))))....(((..(((((....)))))..)))...(((.....)))..))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(.(((....)))..))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..((((((((....((((((((....((((((....((........)).......))))))....).......((....)).)))))))...)))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((.(((....))).)))....(((....)))....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the Thermus thermophilus 70S ribosome in complex with sarecycline, UAA-mRNA, and deacylated P-site tRNA at 3.00A resolution; 16S Ribosomal RNA 6xqe 1v 10 3.0 32817463 10665 aaaaauguaa .......... .......... Crystal structure of the Thermus thermophilus 70S ribosome in complex with sarecycline, UAA-mRNA, and deacylated P-site tRNA at 3.00A resolution; mRNA 6xqe 1x 76 3.0 RF00005 URS000041AF00_562 32817463 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with sarecycline, UAA-mRNA, and deacylated P-site tRNA at 3.00A resolution; P-site tRNA 6xqe 2A 2800 3.0 RF02540,RF02541,RF00002 URS00001698E8_300852 32817463 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu 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(((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...((((((((.....))))))))....[.(((((((((......(...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)..)))))).))))....(((((((((.{.....)))))))))....].(((((}.[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((..))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((.(..(((..........)).).)..)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((((..()..))))))).))..........]]].)....))))))))))...)))))))(((((.(..).)))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..((((..((((.(((..{{..).))))))(((...((((((((.(((((((.((.....)))))))))......))))))))..)))(...((((..)))).....).))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..((....((...(((((....)))))...))....)))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........(((((...((......((((((((....))))))))...)).............)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....))))))).............(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with sarecycline, UAA-mRNA, and deacylated P-site tRNA at 3.00A resolution; 23S Ribosomal RNA 6xqe 2B 120 3.0 RF00001 URS000080DEE8_300852 32817463 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>. ..(((((((((....((((((((....(.(((((...(.....)...))))..).)...)))))).))(((.......((((((((....)))))))).......))).))))))))).. Crystal structure of the Thermus thermophilus 70S ribosome in complex with sarecycline, UAA-mRNA, and deacylated P-site tRNA at 3.00A resolution; 5S Ribosomal RNA 6xqe 2a 1503 3.0 RF00177,RF01959,RF01960 URS000080DFED_300852 32817463 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggau .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>....<<<<.<<<<<....>>>>>.>>>>...<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<((....<<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<......>>....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>.... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((((((((....))))))))).)))))......(((......((((((((..((...(((((((.(((((....((.(((....))).)).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(.(((....)))..))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........((((((...(...(((((((...(((((((....))))))).(..(((....)))..).)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).))))).....))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}... Crystal structure of the Thermus thermophilus 70S ribosome in complex with sarecycline, UAA-mRNA, and deacylated P-site tRNA at 3.00A resolution; 16S Ribosomal RNA 6xqe 2x 76 3.0 RF00005 URS000041AF00_562 32817463 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with sarecycline, UAA-mRNA, and deacylated P-site tRNA at 3.00A resolution; P-site tRNA 6xrq B 14 1.21 URS0001A16A80_101947 38876382 101947 ggcucggcggcgga .............. .............. Structural descriptions of ligand interactions to DNA and RNA quadruplexes folded from the non-coding region of Pseudorabies virus; RNA (5' GP*GP*CP*UP*CP*GP*GP*CP*GP*GP*CP*GP*GP*A-3') 6xrq A 14 1.21 URS0001A16A80_101947 38876382 101947 ggcucggcggcgga .............. .............. Structural descriptions of ligand interactions to DNA and RNA quadruplexes folded from the non-coding region of Pseudorabies virus; RNA (5' GP*GP*CP*UP*CP*GP*GP*CP*GP*GP*CP*GP*GP*A-3') 6xu6 A9 30 3.5 URS0000243D00_7227 34283226 7227 ugcuuggacuacauaugguugaggguugua .............................. .............................. Drosophila melanogaster Testis 80S ribosome; 2S ribosomal RNA 6xu6 A7 120 3.5 RF00001 URS000016432F_7227 34283226 0003735 0005840 7227 gccaacgaccauaccacgcugaauacaucgguucucguccgaucaccgaaauuaagcagcgucgcgggcgguuaguacuuagaugggggaccgcuugggaacaccgcguguuguuggccu <<<<<<<<<.....<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>...<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>..>>>>>>>>>.. (((((((((.....(((((((.....((.(((...(....)...)))...))....)))))).).(.((((......((.((..((....)).)).)).....)))).)))))))))).. Drosophila melanogaster Testis 80S ribosome; 5S ribosomal RNA 6xu6 A8 123 3.5 RF00002 URS000061394B_7227 34283226 0003735 0005840 7227 aacucuaagcgguggaucacucggcucaugggucgaugaagaacgcagcaaacugugcgucaucgugugaacugcaggacacaugaacaucgacauuuugaacgcauaucgcaguccaugcug ........................................<<<.<<.((.....>>........<<<<.....))...........>>>>......>>>....<<.....>>........... ........................................((((((.[[.....))).......((((.....]]...........))))......)))....(.......)........... Drosophila melanogaster Testis 80S ribosome; 5.8S ribosomal RNA 6xu6 B2 1936 3.5 RF01960,RF01959,RF00177 URS000030AF9A_7227 34283226 0003735 0005840 7227 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Drosophila melanogaster Testis 80S ribosome; 18S ribosomal RNA 6xu6 A5 3707 3.5 RF02540,RF02543 URS0002311996_7227 34283226 0003735 0005840 7227 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Drosophila melanogaster Testis 80S ribosome; 28S ribosomal RNA 6xu7 A9 30 4.9 URS0000243D00_7227 34283226 7227 ugcuuggacuacauaugguugaggguugua .............................. .............................. Drosophila melanogaster Testis polysome ribosome; 2S ribosomal RNA 6xu7 A7 120 4.9 RF00001 URS000016432F_7227 34283226 0003735 0005840 7227 gccaacgaccauaccacgcugaauacaucgguucucguccgaucaccgaaauuaagcagcgucgcgggcgguuaguacuuagaugggggaccgcuugggaacaccgcguguuguuggccu <<<<<<<<<.....<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>.<.<<<<<......<.<<..<<....>>.>>.>.....>>>>>.>>>>>>>>>>.. (((((((((.....(((((((.....((.(((...(....)...)))...))....)))))).).(.((((.......(.(....(.....)..)..).....)))).)))))))))).. Drosophila melanogaster Testis polysome ribosome; 5S ribosomal RNA 6xu7 A8 123 4.9 RF00002 URS000061394B_7227 34283226 0003735 0005840 7227 aacucuaagcgguggaucacucggcucaugggucgaugaagaacgcagcaaacugugcgucaucgugugaacugcaggacacaugaacaucgacauuuugaacgcauaucgcaguccaugcug ........................................<<<.<<.((.....>>........<<<<.....))...........>>>>......>>>....<<.....>>........... .........................................(((((.[[.....))).......((((.....]]...........))))......))......................... Drosophila melanogaster Testis polysome ribosome; 5.8S ribosomal RNA 6xu7 B2 1936 4.9 RF01960,RF01959,RF00177 URS000030AF9A_7227 34283226 0003735 0005840 7227 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...((((..[.[[...)))).(((.(.((((...(.((...(.....(((.(((..((....((....................)){))......((........(((..(...((....(((...............((.....((.(.(......)).))......))............(.(............).)..(...(((((.....[[[[..[.....((....))......................)))))....).....((..............))......)))...)).)..)))..(.....(((....((((((((.......))))))))))).......)....(((..(((....))).....))).)).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).....)).).....((.(..((..((........))...))..)..))....(...(.(...........)).........)..((((([.......((((.....((...])).......)))).)))))..)))).))))............({{.......(....(.(.((......(((...(........................)....))).......((.(..............................................................................).))....((((.(.((.......((..((.......)).((.........))....)).......)).)...))))..........................]...]]]]..................))...((((((...((...((.(..((..((((.(((...((........))......))).))))..)).......((....))...).))..).).)).)))..)).)....)........(..(....(...((((.........))))...).)..)........<.....(.((.(((.((((((.(..(((........))).).)))))).)).)..(...}}.)...))......)...)...(((......(.((....)).)....)))....]].].........(.....((..(((((..(((.((((((......((........))..........(((((.(...............((..................)).............((.((....(.(((((.....(((...(........)....((......)).......))).....((....(........((..(..........(((((.........((((((.............................))))))......)))))........)..(..............).....)).......)..............................))......)).))).....)..)))).....).)))))...)).)))).))).(...((.(.(........(.....(((.((((....)))).)))....).........).).))................(..........)............)..))))).....((((.(((.......))).))))......))......)...........(.(..((.(..((((.((..(.(((..(((.(((..((((.......((((.....(.(((.........))).).......)))).......))))..)).))))..))))..)).))))...).))...)..)...(.((.((......)).).).)>........ Drosophila melanogaster Testis polysome ribosome; 18S ribosomal RNA 6xu7 A5 3707 4.9 RF02540,RF02543 URS0002311996_7227 34283226 0003735 0005840 7227 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..............................(..............[...............).........((....))....(...........].............)...............(((((((((.(.....).)))).))))....)........(....(......(((((((......((((.((......(.(((.(......)))))......[[(...).(((.....]])))......)).))))...)))))))....)....)........(.(((..(.......).))).).....(((((..[[[.[[))))).......................................((....))............(..((((....))))............)......................(.(((.(...(((............(((((.......(.((...(..((((((......).)))))..)...)).)........)))))..........((((...((.....((((.((........((.(.(...(((....(..((...(................)....))..)......)))..).).))........)).).))).....))..........(.....(...................(...(.((((.(....(.....)....).))).)..)..)..)........).....))))..........))).....).))).)..((............))((.........(...(((..(((...(.....................)....(......)..........(((.(..(((..(((((((....)))))))..)))...).)))(.((((..(......((((.((..(..................)..).)..))))..)..))).).)...)))..)))...)......(....((.(..........(..(..............(((....)))................(....(.............)...)......)..)........(.......).........))).......).....((..((....(............).(..(((..(.................((...((.((......((....((...(.(((...(.(((((.....))))).).))).)...))..)).......)).))...(.(...((............))...).).......))..).)).)...)...(.....((((.....))).)....).....((......))....(.((.(.(..(.[[....(.(.((..(..................(...(((.((((((.....{..((((.(((...(...........)...)))......................))))....)))))).)))..)...........]]......)..)))).)....)).)).)(.((((.((....(.(((((((((....))))))))).).....)).)))).)....))..))...(((..(..........(((....((....))...)))......)..))).............))((.................(..........).....(((......(.(........(((.................))).....[.(((.((...(............................................)....))...(.(.(.........)).).]((((((((.........(....)......((........))...((((....)))........((((..........(((....((((..((.....{{....)).......((((.....(((((.....(((.....))).....))))).....)))).......(....(.......)....)).))).....)))................)))).....).............)))))))).))).........((......)).)..).((.........))..)))...(.(......(..((.(..(...............(..((...............))..).(.((((..((((......(((..........................................)))...........))))....)))).).(...).......((..(.......((.........)).....(((((....((........))......))))).........((........(......(.....((((....)))).....)...)........))(.(((.........))).)........(...........((((.........)))).....).................).))......).).))...)...).).....))....((.((........).)))................(.............(.(...((.....(.((((...(((((((....((..................(....((((((((....))))))))..............).........))....).))))))......(......((((...((.((.(.................).)).))...............(((.(...((.....................(..).................))..).)))..))))...).........))).))......))..(.(.......)..)..((((...........))))..([((...((..(((.(.(((.((.......)).)))...)..(][..[[).....)))..))...((((...((.......))...))))..((....))..))]]..].....((.(((..((((.]].]]]))))))).))....)......).)................(.......((((...((.......))...))))........)..........((((...(((.....(.(((((......)))))...)...(((.........)))......)))......))).).....((((...........))))....).....................((((((...(....(.((((((.....(....).....)))))).)(((((...(.((....((..(((..}}....)))....))....)).).))))).................}......................).....))))))........((.......(((((((......................(((((((......)))))))............................((((((.(........(((.(..........).)))...........)))))))...................)))))).).....)).((((......................((.(((((..(((....((((....(.((........)).)...))))...))).....))).)).))...)))).. Drosophila melanogaster Testis polysome ribosome; 28S ribosomal RNA 6xu7 B 75 4.9 RF00005 URS000080DDE9_7227 34283226 0030533 0006412 7227 agcagaguggcgcaguggaagcgugcugggcccauaacucagagguccgaggaucgaaaccuugcucugcuacca .<<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ..(((((..((((.......)))).(((((.......))))).....(((((.......))))))))))...... Drosophila melanogaster Testis polysome ribosome; P-tRNA 6xu7 v 12 4.9 34283226 7227 cgguguggcccu ............ ............ Drosophila melanogaster Testis polysome ribosome; mRNA 6xu8 A9 30 3.0 URS0000243D00_7227 34283226 7227 ugcuuggacuacauaugguugaggguugua .............................. .............................. Drosophila melanogaster Ovary 80S ribosome; 2S ribosomal RNA 6xu8 A7 120 3.0 RF00001 URS000016432F_7227 34283226 0003735 0005840 7227 gccaacgaccauaccacgcugaauacaucgguucucguccgaucaccgaaauuaagcagcgucgcgggcgguuaguacuuagaugggggaccgcuugggaacaccgcguguuguuggccu <<<<<<<<<.....<<<<<<......<<<<<..............>>>..>>.....>>>>>.>...<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>..>>>>>>>>>.. (((((((((.....(((((.........((((...(....)...))))..........)))).).(.((((......((.((..((....)).)).)).....)))).)))))))))).. Drosophila melanogaster Ovary 80S ribosome; 5S ribosomal RNA 6xu8 A8 123 3.0 RF00002 URS000061394B_7227 34283226 0003735 0005840 7227 aacucuaagcgguggaucacucggcucaugggucgaugaagaacgcagcaaacugugcgucaucgugugaacugcaggacacaugaacaucgacauuuugaacgcauaucgcaguccaugcug ........................................<<<.<<.((.....>>........<<<<.....))...........>>>>......>>>....<<.....>>........... ........................................((((((.[[.....))).......((((.....]]...........))))......)))....((.....))........... Drosophila melanogaster Ovary 80S ribosome; 5.8S ribosomal RNA 6xu8 A5 3703 3.0 RF02540,RF02543 URS0002311A19_7227 34283226 0003735 0005840 7227 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..............................<<<<<<<....<<....>>.....>>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..[[[..........<<<<<<<<<<.....>>>>>>.>>>>.............<.<.........<<<<<<<......<<<<<<<.<<.<...<<<<.......>>>>.......((......<<<.....))>>>.>..>>>>>>>>>...>>>>>>>.......>.>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>...................................<<<<<.<..<<<<<.........<<<<<<<......<<<<<...<<<<<<<<<<.....>>>>>>>>.>>..>>>>>.......>>>>>>>.......<<<<<<..<<<<<<<<<<<.<<.<.....<<........<<<.....<.....<..................>....>.........>>>.......>.>....>.>>.>.>>>>>>>>>>..........<<<.<.....<<<<<<....>>>>>><<<<<<<..<<<<..<<<...>>>..>>>>...>>>>>>>.....>.>>>......>>>>>>........>>>>>....>.>>>>>..<<<<........>>>><<<<<<.....<<.<<<<<<<<<..<<<...<<<.......>>>...>>>...<......>..........<<<<<<..<....<<<<<......>>>>>...>....>>>>>><<<<<<<<<<....<<<<<.<..<....................>...>..>>>>>>>>>>>>.>>>...>>>>>>>>>.>>...<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>.><<.<<<<................<<.<.<<<<<<....<<<....<<<....<<<...<.<.<<.......>>.>.>.>>>....>>>..>>.>....>>>>>>...<.<.<.<<<..........>>>.>.>.>.....>.>>....>>>>...>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<(((........<<<<......<<..........<<<.<<<<<<<<<<.......<<<<<.<<.....................>>......................>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>...>>....>>>>>>><<<<<<<<<.....<.<<..<<<<....>>>>...>>.>.....>>>>>>>>>....>>>>>>..<<<<<<<<.<<......<<<<..<<<....>>>.>>>>...>>>>>>>>>>........>>>>>><<......<<......<<.<<........>>.>>.<<<<<....<<<<<.<<...<<<<<....<<.....>>..>>>>>....((<<<<<<...<<<<...<<....>>..........<............>...>>>>....>>>..<<<<<........>>>>>))<<<<<<<<.....................<<........>>....<<<....>>>......<<<<<<<....<<<..<<<<<...<.<<.<<<<..{{{..>>>>.><...<<<<<...<<<<<<<<....<<<.....>>>....>>>>>>>>...>>>>>.....><<<<<<.......>>>>>>>.>...>..>>>>..>>>..........>>>>>>>.................>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>.>>>>>..<<<<.....<<<<<<<.<<...............<<<<<...............>>>>><<.<<<<<<<<<.........<<........................................>>..............>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<...<.<<<<....>>>>..>..>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.........{{{..{{[[[[..<<<<<.<<<<<<<<..<<<<<<....<..<<<.............<<<....<<<<<<<<....>>>>>>>>..............>>>....>>>..>.....>>>>>>...<<<<<.....<<<<...<<<<.....<.........>.......>>>>...............<<<<<...................................................>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<.<<<<...<<<.<<.......>>.>>>.....<<...(((>>....>>>>.>>...<<<<.<<<<.......>>>>.>>>>.<.<....>.>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}.}}}.......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>.>...>>>.>>....<<<<<<<....>>>.>>>>........}}}.]]]]]........<<<<<<<<..<<<<.<.<<<<<<................>>>>>>.><<<<<....<<<...<<<<<<<<<.}}}..>>>>..>>>>>...>>>..>>>>>.<<<<....<<<<...........>>>>....>>>>.>>>>....>>>>>>>>.......<<<<....<<<<<<<<......................<<<<<<<......>>>>>>>.............................<<<<<....<.................................>...>>>>>....................>>>>>>.>>..>>>>.<<<<<<<.............>>....<<<<<<<<<.<<<....<<<<....<..............>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ..............................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((........(((((((((.(.....).)))).))))....)........(...........(((((((......(((((((.((...({(((.........))))......[[(...).(((....}]])))....)))))))))...))))))).........)...)....(((((((........))))))).....(((((..[[..[[)))))..)))..................................((....))............(..((((....))))............)......................(((((.(..(((((...........(((((......(((.(......(((.(((.....))).)))......).))).......))))).........((((((.((((((.(((((.((........(.........((.....(.(.(.(..................).)).).........)).........).......)).).)))).)))))....................((((((....)))))).(((((((...((..((.....))..))....)))))))...............).))))))........)))))....).))))).[((((........))))((((((.....((.(((((((((..(((..((((.......))))..)))...(......)..........(((((...(.........(....)........).....)))))(((((((((......(.((....(....................)......)).)..)))))).)))...))))))))).))...((.(...((((((.....(((((((((..(((....(((((((....)))))))....[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(.((................((...((((((....(((....(((..(.(((...(..(.((.....))...)).))).)..)))..)).)....))))))...(.(.(.(((..(......)))).).).).......))....)).)...))..((((.(((((.....))))).))))....(((......)))...(((((((...(([[[...(.(.(((((.......(...........((.((((((((((.......(...(..(.....................).......................)...)...))))))))))))...........]]].)....)))))))))....)))))))(((((((((............(((....))).............)))))))))....))))))(.((((((((.((......((((..(((....))).))))...))))))))))..).....))))))((......((......((.((........)).)).((((.....((((..((...(((((....((.....))..)))))....[[(((.((...(((....((....))............................)))....))...(((((........)))))]]((((((((.....................((........))....(((....)))......(((((((....(((..(((((...(.((.((((...{{..)))).)....(((((...(((((((.....(((.....))).....)))))))...)))))......((..(((.....)))..))).)...)..))))..))).(...)....))))))).................)))))))).)))..)).....((......)).)))).((.(.....).))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((.((.(........((........................................))..............)))...))))).))(...).......(((((((((.].((.........))...(((((((....((((....))))......))))))).}.(((.(((..((((((.....((.....((((....)))).....))..))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......(((..((((((..(((((.((((((((..((((((....(((((((.............((....((((((........))))))..............))....))))))).....))))))...(((((.....((((...(((.........................)))...............(((((...................................................)))))..))))..))))).....))))))))..)))))..(((......[)).)((((((..........]))))))(.((....(..(((.(.(((.((.......)).)))...).((...[[[))....)))..)....((((.((((....{..)))).))))............))]]].......((((((..((((.]]..]]))))))))))....)}....))))..)).))).......((.(....(((.(...((.......))...).))).....).).)........((((.(((((...(.(.(((((......)))))...).).(((.........)))......)))).)...))).).....(((((((....))).))))..>.))..))).)))))........((((((((..(((..(.((((((.....(....).....)))))).)(((((...((((...(((((((((.}}...))))..)))))...)))).)))))..(((....(((.............)))....)))...)))....)))))))).......(((....(..(.((((.......((.............(((((((......))))))).........).)...................(((.........(.....................)..........)))......................)))).).....)))).(((((((..(.......)..))....(((((((((.(((....((((....(..............)...))))...)))....)))).)))))..))))).. Drosophila melanogaster Ovary 80S ribosome; 28S ribosomal RNA 6xu8 B2 1936 3.0 RF01960,RF01959,RF00177 URS0002311A0D_7227 34283226 0003735 0005840 7227 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...<<<<<.{.((((>>>>><<<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<.........>>...>>.>>......<<........<<<.<<<..<<....<<<<..............<<.....<<.<<<.....>>>.>>......>>...........<<<<............>>>>.<<..<<<<<.....(((...((..<<<<....>>>>........<........>..>>>>>...>>...<...................>....>>>>...>>>>>.>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>..>>>..>...>>.>.....<.<<<<<...<<<......>>>....>>>>..>.>.....<<.................>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>>.........<<<[[.....<<<<...<<<.<<.....<<<<...<<......................>>....>>>>......<<..................................................................................>>....<<<<<<.<<.......<<...<.......>..<<<.......>>>....>>.......>>.>>..>>>>..........................))...)))..................>>....<<<<..<.<<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>.>.>>.......<<....>>...>>>>...>>>.>.>>>...>>>...>>>>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<.<<<<<<....<<<........>>>...>>>>>>.>>>...<<..]]>>...>>......>>>.>>>.<<<......<<<......>>>....>>>..)))).}<<....<<<<<<<..<<..<<<<<.<<<<.<<<<<<......<<........>>..........<<<<......................<<<........>>>.................<<.<<<...<.<<<<<.....<<<.<..............................>.>>>....<<<<..<<..<.<........<.........<..<..........................................................>..>.......>...<<<<........>>>>..........>.>.>>............................>>>>.....>>.>>>.....>.>>>>>........>>>>...>>.>>>>.>>>.>...<<<<<<..............<<<.<<<<....>>>>.>>>..............>>>>>>.........<<.....<..........>....>>.........>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>....>>....<..<<.<..<<<<.<<....<<<<.<<<.<<<..<<<<..<....<<<<.<<....<<<.........>>>.....>>..>>>>....>..>>>>..>>>.>>>.>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))((((.((((((...(.((..((.....(((.(((..((....((....((.........))...)){))......(((.......(((.(((..((....(((((.............((.....((.(.(......)).))......))............(((............)))....(.((((......[[[[...[.((.((....)).))....................)))).).........(.............)......)))))...))))).))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)...)).).......((((....((........)).....)))..).....(.(.(..............)..)......)..((((([[......((((.....((..]])).......)))).)))))..)))))))))).........((({{...(.((((...(((.((......(((.................................))).......((..................................................................................))....((((((..(.......((..((.......)).((((....).)))....)).......)..))..))))..........................]...]]]]..................))...((((((..(.(...((((..(((.((((((((...((........))......)))))))).))).......((....))...))))..).).)).)))..))))...))))....((((((....(...((((.........)).))..).))))))......<...(((.((.(((.((((((.(..((..........))..))))))).)))...((.}.}))...))......))))))).(((......((((....))))....)))...]]].](((....(((((...((..(((((..(((.((((((.......(........).........(.((((..(...................(.(........).).................((.((....(.((((((....(((..................................)))....((((...(..(......(..((............((.......((.(......................................)))....))..........))..((((........)))).....)......).)............................).)))....))).))).....)..)))).....)..)))))..)).)))).))).(...((((((........(.....(((.((((....)))).)))....).........))))))......(....(....................)....)..)..))))).....((((((((.......))))))))......))....)))))...).))..(.(..((.(..((((.((..(.((((.(((.(((..((((..(....((...((....((...........)).....))....))....)..))))..))).))).)))))..)).))))...).))...)..)..(((((((((....)))))))))>........ Drosophila melanogaster Ovary 80S ribosome; 18S ribosomal RNA 6xur A 12 1.1 URS000080E0B7_32630 31999864 32630 cgcgnauuagcg ............ ............ RNA dodecamer with a 6-hydrazino-2-aminopurine modified base; RNA dodecamer with a 6-hydrazino-2-aminopurine modified base 6xus A 12 1.1 URS000080E0B7_32630 31999864 32630 cgcganuuagcg ............ ............ RNA dodecamer with a 6-hydrazino-2-aminopurine modified base; RNA dodecamer with a 6-hydrazino-2-aminopurine modified base 6xyw 1 2842 3.86 RF02540,RF02541 URS0001A16A87_3702 32251374 0003735 0005840 3702 gaaugcauuggauggaugcccgggcauugagaaggaaggacgcuuucagaggcgaaaggccauggggagauaccgucugugauccauggaucuccgaucgggaaaccguauccaagcuccguggcuagucugcgcucuuuggacuuugaaaacuuagcgaacugaaacaucuaaguagcuaaaggaagggaaaucaaccgagaccccguuaguagcggcgagcgagagcggauuugggauuuuaagaaaaagaaagacgaagcacuucuuuuucgccagguuuacuguaauugugaaaagguuggaagaucuggccaaagaaggugauagccccguagauucguuccuaugguucgauccuucccaguaaaacgcggcguguucgaauucugaucgcuuuuacgcgagaaagggggaccacccucuaagccuaaguauuccucaaugaccgauagcguacaaguaccgugagggaaaggugaaaagaacccuaugacgggagugcaauagagaaccugagauccgaugcgaacaaucagucgaaggaguagucaagcgcacucacucuaacggcguaccuuuugcaugaugggucagcgaggaaaugggaagagcggcuuaagccauuagguguaggcgcuuuccaaagguggaaucuucuaguucuuccuauuugacccgaaaccgaucgaucuagccaugagcagguugaagagagcucuaacaggccuuggaggaccgaacccacguauguggcaaaauacggggaugacuuguggcuaggggugaaaggccaaccaagaucggauauagcugguuuuccgcgaaaucuauuucaguagagcguaugaugucgauggcccgagguagagcacucaaugggcuaggguggcuuaccaaccccagggaaacuccgaauacaggccguucucguuuguacagacagacuuuuggggugcuaagauccaaagucgagagggaaacagcccagaucguacgcuaaggucccuaagcaaucacuuaguggaaaaggaagugaucgagcgaugacaaccaggaggugggcuuggaagcagccauccuuugaagaaagcguaauagcucacuggucuagcuccauggcaccgaaaauguaucagggcucaagugauucaccgaagcgacgagaccuugaaagcugcuuuuucaagugucaguagcggaacguucugucaaucggggaagguuuuuggugacaagaccuggagauaucagaagugagaaugcugacaugaguaacgauaaauccugugaaaaacacgaucgccugccaguggaaggcuuucugcguucagucaaucuacgcagagugaaucggucccuaaggaacccccgaaagggcugccguccgauggguacacgaaagugacgaaguugcuuugacuacaaaaccaugccucucucuuggagcgaauuggaugaucgggccgagggcagcguagcgccucuuccccucacucuccuuucuccaauaugaaccuugagucaucaaaggcgagucuguuuauagucgcgacucuugucauagucaagaagguugaaacuuccaggaaaaaacuucgaauugggagggcgauccucccggugaacugaccguaccccaaaccgacacaggugaacaaguagaguauacuagggcgcuugagagaaccaugucgaaggaacucggcaaaaugaccccguaacuucgggagaaggggugcucuccuaucuuuugauuaggaaagcggcacauaccaggggguagcgacuguuuauuaaaaacacaggacucugcuaagugguaacacgauguauagagucugacaccugcccggugcuggaaagucaaaaggagaaguguuauaagcuuugaauggaagccccgguaaacggcggcaguaacucuaacuguccuaagguagcgaaauuccuugucgcauaaguagcgaccugcacgaaugguguaacgacugccccgcugucuccgacauggacccggugaaauugaauucuccgugaagaugcggaguaccaacggcuagacgguaagaccccgugcaccuucacuauagcuucgcagugacaaccuugaucgaauguguaggauaggugggaggucgugacauagaaggaccaauccugaaagaccacucuuucgucuaagggugccuaaccgccgcggcgggacacugcgagguggguaguuuaucuggggcggaugccuccuaaagaguaacggaggugugcgaagguaggcucaagcuaagauucugcucgugagcguaaugguauaagccugccugacugugagaccgacuggucgaacagagacgaaagucggccauagugauccgggagucccguguggaagggcucucgcucaacggaucaaagguacgccggggauaacaggcugaugacucccaagagcucuuaucgacggagucguuuggcaccucgaugucgacucaucacauccugggguugaagaaggucccaaggguucgguuguucgccgauucaagugguacgugaguuggguuuagaacgucgugagacaguucgguuccuaucuaccguugguguuaaagggagaacugcgaggagccaacccuaguacgagaggacuggguugggccaaccuaugguguaccgguuguuaugccaauagcagcgccgggcagcuaaguugguauggaagaacugcugcuuagcgggaaauccuucucuauacaaguucucggaacagguuuuagaacagaacuucgauaggcgggagguggaagcaccgcgaggugugaagccaucucguacuaaacga ...<<<<<<<<<<....<<<..<<<<<<<<<<.....<<<<<<........>>>.....<<<<<<<..<<.....>>.....>>>>>>>...>>>...<<<....>>>..<<<<<<...<<<.........>>>...>>>>>>.........<<<<<<.....<......>......>>>>>.>...<.....<<....>>....<<<<.....<<.....>>....>>>>....<<................<<<<.........>>>>.....<<<..............<<....<<<........>>>.<<.......((.....>>))....>.>.........>>>..................<.<<..<..........>..>>.>................<<<<<..((((>>>>>...>>....>..>.>>>>>>>.>>...............<<....>>....>>.........<<<......>>>...............>....>>>>>>>>>>........<<<<..<<<<<<<<.......>>>.>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<.<<<...<<<....>>>...>>>........................>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<..<<.....>>..>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<....<.<<<<<.<.....<<<...<<..<<<<...<<........>>...>>>>..>>..>>.>.....>.>>>>>.>.....>>>>>>.>...<<<<.<<<<<.........>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<((......<<<<<<...........<<..<<.<<.<<<<.......<<<...<<...<<<<.......>>>>...>>........<<<......>>>....>>>...>>>>.>>.>>.>>............))......>>>>>>.>>>...>>>>>>><<<<<<<<<<<.....>>>>>>>>.>>>....>>>>>>..<<<<<...<<<......<<.<<<<<....>>>>>.>>...>>>..>>>>>........>>>>>><......<<.....<<<.<<.......>>.>>><<<<<....<<....<<...<<<<<<...<<.....>>.>>>>>>......<<<<<<....<<....<<<....>>>......>>....>>.....<<<<......<<..<....<...............................<.<<...>>...>.................................................>...<.<<<.....<........<<<<<<<........>>.>>>>>.........>.....>>>>...>..>>............>>>><..<<<<<.........>>>>>.>......>>>>..>>.....<<......>>...>>.<<<<.....>>>>.>>>>>..<<.<....<<<<<<<<.<<...............<<<<<...............>>>>><<<.<<<<<<......>.>>>>>.>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<...<<........<<<<<.......>>>>>........>>.>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>.>>>>.....>.....<<<<<........>>>>>..<<<<<<<.<<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<.<<.<<<<<..<<<..............<<<...<................>.............>>>.....>>>..>>>>>.>>.>...<<<<<..>>>>>....>>>>>>>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<.........>>>.....<..[.(((.>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<.......>>>>.....>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>>>>>>>>>.........<<<<<<...<<<<..<<<<<<<...............>>>>>>><<<<<<...<<<<...<<<<<<<<<<<....>>>>>>..>>>>>...>>>>.>>>>>><.<<<....<<<<<....>>>>>....>>>>>>>>.......>>>>>>......<<<<<.......>>>>>....<<<<<<<<<<<<....<<<<<....>>>>>...>>>.>>>>>>.>>>..... ....((((.(((.....(((..(((((((((.(....(((((((...)...))).....((((((...((.....))......))))))...)))...(((....)))...(((.....((..(.....)..)).....)))..........((((((.....(...[..)......))))).).........((....))....((((.....((.]...))....))))....((................(((..(......).))).....((.....................((((......)))).[[(...)..((.....]])).................))..................(.(..(............)..).)................(((((..[[[[)))))...)).......).))))))).))...............((....))....))......(..(((......)))..............)).....))).)))).......(.((((...(((.(((.......)))..)))...))))...(.(........).).((((((....(((((((((((.(.((....(((....)))....)).....(....).............).)))))))))))...(.(...((((((.....((((((((((.((((...(((.((.......).))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).)...((((((....(((((....))))).((.((((...((..((((.(.....(((...((..((((...((..(.)...))...))))..))..)).).....).))))...)..).)))).).)...((((.((.(...........).))))))....(((......)))...((((.(((...((([[....(.((((((.....(.....((..(..((..(((........((.(.(((..(((.........)))..))).....(...((......)).).).))....)))..))..).))............]].)....))))))))))...)))))))((((((((((.......))))))).)))....))))))(((((((....((......((.(((((....))))).))...))...))))).)).....))))))(......((.....(((.((.......)).)))((((.....((....((..(((((((...((.....)).))))))......(((.((....(.....(((....))).......)....))..(..((((.......(..(....(............(....(......(........((...))..........).....)....).......................{.......).....(.(...(.(......(.((((.(..........)..))))...).....).)...).)....)..)..(..).......))))..(.((((.........)))).).....)..))).))).....((......))...)).((((.....))))..))))...(.(....((((((((.((..(....(.......(((((....(.{..).....)))))(((.(((((.........))))).)))(...).......((((.((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((...((....(...(((((.......)))))...)....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).)).)))).)..))).)))))))).).).)).....)).[..(((((......].)))))..(((((((..(((.((......((((.(.((((..(((((.(((((((((.(.((.((((....((...............((...((..............)).............))......))....)))).)).)...((((....))))....)))))))))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((.........)))...).(.][.[[[.)....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....((((((..((..]]]]..)).)))))).....)}......))))...)))))......((((..(.((((((...((.......))...))))))...).)).).)......((((.((((((..(((((((((......))))))..))).((((.......)))).....)))))..)...))).).....(((((((....))).))))..>.))..))).))))))).........((((((...(((...(((((((.....(....)....)))))))((((((...((((...((((((((((.}....)))))..)))))...)))).))))))..(((....(.((((.).))).)....)))..))).......))))))......(((((.......)))))....((((((.(.((.....(((((....)))))....))..).))).)))..... Structure of the plant mitochondrial ribosome; RNA (2842-MER) 6xyw 3 118 3.86 RF00001 URS0000240B4B_3702 32251374 0003735 0005840 3702 aaaccgggcacuacggugagacgugaaaacacccgaucccauuccgaccucgauauguggaaucgucuugcgccauauguacugagauuguucgggagacaugguccaagcccgguga ..<<<<<<<.........<<...<.....<<<.<<...............>>....>>>.....>..>>...<<<<..<<.<<<<......>>>>...>>>>>>.....>>>>>>>.. ..(((((((.........(.(........(((.(((...(.....)...)))....)))........))...((((...(.((((......))))..)..)))).....))))))).. Structure of the plant mitochondrial ribosome; RNA (118-MER) 6xyw 2 1743 3.86 RF00177,RF01959,RF01960 URS0001A16A70_3702 32251374 0003735 0005840 3702 uagucaaaagaagaguuugauucuggcucagaaggaacgcuagcuauaugcuuaacacaugcaagucgaacguuguucucggagcuaggcagcuccuagcuccuugucucggggaagaguugagaacaaaguggcgaacgggugaguaaggcgugggaaucugccgaacaguucgggccaaauccugaagaaagcuaaaaagcgcuguuugaugagccugcguaguauuagguaguugguuagguaaaggcugaccaagccaaugaugcuuagcuggucuuuucggaugaucagccacacugggacugagacacggcccggacucccacggggggcagcaguggggaaucuuggacaaugggcgaaagccgauccagcaauaucgcgugagugaagaaaggcaaugccgcuuguaaagcucuuucgucgagugcgcgaucaugacaggacucgaggaagaagccccggcuaacuccgugccagcagccgcgguaaaacggggggggcaaguguucuucggaaugacugggcguaaagggcacguaggcggugaaucggguugaaagugaaagucgccaaaaaguggcggaaugcuuucgaaaccaauucacuugagugagacagaggagaguggaauuucguguggaggggugaaaucuacagaucuacgaaggaacgccaaaagcgaaggcagcucucugggucccuaccgacgcuggggugcgaaagcauggggagcgaacgggauuagauacccugguaguccaugccguaaacgaugaguguucgcccuuggucuacgcagaucaggggcucagcuaacgcgugaacacuccgccuggggaguacggucgcaagaccaaaacucaaaggaauugacgggggccugcacaagcgguggagcaugugguuuaauucgauacaacgcgcaaaaccuuaccagcccuugacauaugaacaacaaaaccuauccuuaacgggaugguacucacuuucauacaggugcugcauggcugucgucagcucgugucgugagauguuuggucaaguccuauaacgagcgaaacccucgucuuguguugcucagacaugcgccuaaggagaaaggcuugaaaaccgaagugagccaaggagccgagugaugugccagaccuagcuaggccaacucgacgucgcgacgucgaguuggcggcggagaaagacucggcauucaggcgagccgcccgguggugugggacgaaguaaguggguuuaguacgcccugccaaaacggcuccgaaacaaacaaaaaggugcgugccgcacucacgagggacugccagugauauacuggaggaagguggggaugacgucaaguccgcauggcccuuaugggcugggccacacacgugcuacaauggcaauuacaaugggaagcaaggcuguaaggcggagcgaauccggaaagauugccucaguucggauuguucucugcaacucgggaacaugaaguuggaaucgcuaguaaucgcggaucagcaugccgcggugaauauguacccgggcccuguacacaccgcccgucacacccugggaauugguuucgcccgaagcaucggaacaaugaucacccaugacuucuguguaacacuagugccacaaaggcuuuugguggucuuauuggcgcauaccacgguggggucuucgacuggggugaagucguaacaagguagccguaggggaaccuguggcuggauugaaucc ............<<<<..[.((((.>>>>.<<<<.<<<<<..<<.<<<<<.....<<<.<<<..<<<..<<....<.<<<.<<<<<<<<.....>>>>>>>><<<.<<<...>>>.>>>..>>>.>....>>>>>......<<.......<<<<<<<..<<...<<<<<<<<<<<<<......>>>>>.....<<......>>>>>>>>>>..>>.>>>>>>><<<....<<<...<<<<<<<.......>>>>>>>.>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<.......>>.>>>>..>>.>>>.>>..<<<<......<<<<......>>>>.....>>>>...<.<<<<<<................>>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<..<<<<<<<<<<.....<<<<<<.....>>>>>>...>>>>>>>..>>>.>>>>>>....<<<.<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>..>>>....>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<....>>>>>>>>>>>...<<..))>>....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<..<<<<<..<<<<<<<<<<......<<........>>........<.<<<<<<<......<<<.<<..........<<<<<<....>>>>>>.........>>.>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>....<<......>>....>>>>>>.....<<<<.<<<<<.<(.<<.....<<<<<<<<.............................<<......<<<<<<<..<...<<......<..>.....<<<<<<<<<<<..>>>>>>>>>>>......>>...>..>>>>>>>......>>..................<<.<<....<<.....>>.....>>.>>.............................>>>>>>>>..>>...>)>>>>>.....<<<<<<...>>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>>..>>.>>>>>>>>.....<<<<<<<......<<..<<...<<<....>>>...>>....>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>.....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<<<<<.....<<<<<<<<<....<........<<<<<<<<<.<......<...<.<............>.>....>.....>.>>>>..>>>>>.......>...>>>>>>>>>.....>>>>>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>........... ............((((..[.[.[..)))).((((.(((.(..((.(.((((....(((.(((..(.(..((..((.((((.((((((((.....))))))))((..((((.))))..))..)))).).).))).)......(((.......((((((..((...(.(((((.((.((......)).)).....((......)).))))).)..)).)))))).(((....(((..(((((.((.......)).))))))))......)))..((((((((....))))...))))))).(.(((............))).).(.((....)).)...)))))).).....(.(((...(.(((....))).))))).)).).).))..(((.......((((......))))......)))......((((..................))))........((((([[[...(((((.....((.]]])).......))))))))))..).)))))))..........((([....(.((((....((.((((((..(((.((((((......(((((.....)))))....)))))).)..)).))))))..(.(((.(((...((((((((....(((((.....((........))........)))))....).......((....)).)))))))..)))..)))...)))....))))....((((((...((...(.((.........)).)...))))))))......{...((((((..(((((((((((....)))))))))))...((...]))....)))))))))).(((......((((....))))....)))...].].]((((..(...(((.((..(((((..((((((((((......((........))........(..((((((..(...((.............(.((((......)))).)............))).((.((....((((((.(....(((((((((....)))....((......))....)))))).....((((..((.((...((.....((.((.((...........(.(....).).............(..(((((((....(.((......(()).....(((((((((((())))))))))))......)).)....)))))))...)...................(..((.((....((.....)).....)))).)............................)).)).))..))....)).))...(..(((((.....))))).....)..)))).....).).)))...))..))))....)))))).)..)).)))))))).(...(((((((.......(..((...((......))...))....)......)))))))......(.....((((((........)))))).....)..)..))))).....(((((((.........)))))))......))...)))....))).))..(.(..((.(.((((((((.....(((((((((....(.....(..(((((((((((.(.......((((............))).).......))))))))..))))...)...)...))))))))).....))))))))..).))...)..)..((((..(((....)))..))))}.......... Structure of the plant mitochondrial ribosome; RNA (1743-MER) 6xz7 A 2897 2.1 RF02540,RF02541 URS0000A7632D_83333 32144191 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<...>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<..<<....>>...>>>>>.>.....>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<..<<<............<<<<<...<<<<....<<<<<<<<....>>>>>>>>.>>>>.............>>>.>>..>>>..>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. .(((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((.(......).))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((((((((...((..(............((...((......(.((((((....)))))).)...)).............))...)..))...))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).)))))))).. E. coli 50S ribosomal subunit in complex with dirithromycin, fMet-Phe-tRNA(Phe) and deacylated tRNA(iMet).; 23S rRNA 6xz7 B 120 2.1 RF00001 URS0000049E57_83333 32144191 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). E. coli 50S ribosomal subunit in complex with dirithromycin, fMet-Phe-tRNA(Phe) and deacylated tRNA(iMet).; 5S rRNA 6xz7 f 76 2.1 RF00005 URS00002905B5_83333 32144191 0030533 0006412 83333 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... E. coli 50S ribosomal subunit in complex with dirithromycin, fMet-Phe-tRNA(Phe) and deacylated tRNA(iMet).; Deacylated tRNAi(Met) 6xz7 g 76 2.1 RF00005 URS000011107D_4932 32144191 0030533 0006412 4932 gcggauuuancucagnngggagagcnccaganunaanaunuggagnucnugugnucgnuccacagaauucgcaccn <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((.........)))).....(((((..]....)))))))))))).... E. coli 50S ribosomal subunit in complex with dirithromycin, fMet-Phe-tRNA(Phe) and deacylated tRNA(iMet).; fMet-Phe-tRNA(Phe) 6xza A1 1523 2.66 RF00177,RF01959,RF01960 URS000081169C_83333 32144191 0003735 0005840 83333 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccggccagcagcccgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgauaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgccguacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgaacaagguaaccguagggccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<........>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.......)))........>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<......>>..........<<<<<<<......<<<<<<<....<<<.<....>>>>......<......>..>>>>>.>>.<<<.<....<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>.>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>......<<..<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>....>>........<<<<<<<<<.>>>>>>>>>...... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((.(....).))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((....(..]]]).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((......))..........(((((((..(...(.(((((.....(..(....)..).......(....)...)))))..)).((.(.(...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(.((..((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))....))..)..)..(((((((((.)))))))))}..... E. coli 70S ribosome in complex with dirithromycin, and deacylated tRNA(iMet) (focused classification).; 16S rRNA 6xza A2 2897 2.66 RF02540,RF02541 URS0000A7632D_83333 32144191 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<...>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<..<<....>>...>>>>>.>.....>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<..<<<............<<<<<...<<<<....<<<<<<<<....>>>>>>>>.>>>>.............>>>.>>..>>>..>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. .(((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((.(......).))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((((((((...((..(............((...((......(.((((((....)))))).)...)).............))...)..))...))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).)))))))).. E. coli 70S ribosome in complex with dirithromycin, and deacylated tRNA(iMet) (focused classification).; 23S rRNA 6xza B2 120 2.66 RF00001 URS0000049E57_83333 32144191 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). E. coli 70S ribosome in complex with dirithromycin, and deacylated tRNA(iMet) (focused classification).; 5S rRNA 6xza f2 76 2.66 RF00005 URS00002905B5_83333 32144191 0030533 0006412 83333 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... E. coli 70S ribosome in complex with dirithromycin, and deacylated tRNA(iMet) (focused classification).; Deacylated tRNAi(Met) 6xzb A1 1523 2.54 RF00177,RF01959,RF01960 URS000081169C_83333 32144191 0003735 0005840 83333 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccggccagcagcccgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgauaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgccguacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgaacaagguaaccguagggccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<........>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.......)))........>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<......>>..........<<<<<<<......<<<<<<<....<<<.<....>>>>......<......>..>>>>>.>>.<<<.<....<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>.>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>......<<..<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>....>>........<<<<<<<<<.>>>>>>>>>...... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((.(....).))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((....(..]]]).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((......))..........(((((((..(...(.(((((.....(..(....)..).......(....)...)))))..)).((.(.(...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(.((..((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))....))..)..)..(((((((((.)))))))))}..... E. coli 70S ribosome in complex with dirithromycin, fMet-Phe-tRNA(Phe) and deacylated tRNA(iMet) (focused classification).; 16S rRNA 6xzb A2 2897 2.54 RF02540,RF02541 URS0000A7632D_83333 32144191 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<...>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<..<<....>>...>>>>>.>.....>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<..<<<............<<<<<...<<<<....<<<<<<<<....>>>>>>>>.>>>>.............>>>.>>..>>>..>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. .(((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((.(......).))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((((((((...((..(............((...((......(.((((((....)))))).)...)).............))...)..))...))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).)))))))).. E. coli 70S ribosome in complex with dirithromycin, fMet-Phe-tRNA(Phe) and deacylated tRNA(iMet) (focused classification).; 23S rRNA 6xzb B2 120 2.54 RF00001 URS0000049E57_83333 32144191 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). E. coli 70S ribosome in complex with dirithromycin, fMet-Phe-tRNA(Phe) and deacylated tRNA(iMet) (focused classification).; 5S rRNA 6xzb f2 76 2.54 RF00005 URS00002905B5_83333 32144191 0030533 0006412 83333 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... E. coli 70S ribosome in complex with dirithromycin, fMet-Phe-tRNA(Phe) and deacylated tRNA(iMet) (focused classification).; Deacylated tRNAi(Met) 6xzb g2 76 2.54 RF00005 URS000011107D_4932 32144191 0030533 0006412 4932 gcggauuuancucagnngggagagcnccaganunaanaunuggagnucnugugnucgnuccacagaauucgcaccn <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((.........)))).....(((((..]....)))))))))))).... E. coli 70S ribosome in complex with dirithromycin, fMet-Phe-tRNA(Phe) and deacylated tRNA(iMet) (focused classification).; fMet-Phe-tRNA(Phe) 6y0g A4 17 3.2 32268098 9606 uuuuuuuuuuuuuuuuu ................. ................. Structure of human ribosome in classical-PRE state; mRNA 6y0g B4 76 3.2 RF00005 URS00005AA258_9606 32268098 0030533 0006412 9606 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>><<<<<<<.....>>>>>>.>...<<<<<.......>>>>>>>>>>>>.... ..(((((..((((.....[..)))).(((((.......))))).....((.((..]....)).)))))))...... Structure of human ribosome in classical-PRE state; tRNA 6y0g D4 76 3.2 RF00005 URS00005AA258_9606 32268098 0030533 0006412 9606 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).(((((.......))))).....((.((..]....)).))))))))).... Structure of human ribosome in classical-PRE state; tRNA 6y0g L5 3644 3.2 RF02543,RF02540 URS0000E60B81_9606 32268098 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcggcccggcggaucuuucccgcgcgggggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucgggggcccccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcgcucuccccccucccggcggggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccgggggaggccacgcgcgcgucccccgagggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcagacccgacccgccacgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaagaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggcaagucgcuaaggagguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagcgggcggcgcgccgcgcccggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcugggucggucgcggccggcgccuagcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacaguuuuuucacugacccggugaggcgggggggcgagccccgaggggcucucgcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccggucccccgccgggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>>..<<<<<<<<<....<<<<<<<<........<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>...>>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<......>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<<<..<<<<<<<.......<....<<<<<.<<<..<<......>>>>>>>>>>>......>>>>...>>>>>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<.<<<<<<<<<<.<<<<...<<..<<<.<<.<<<<......<<<<<<<....>>>>>>>.......>>>>.>>>>>........>>>>>>...>>>>>>>>>>....................<<<<<<.<<<<<<<.......>>>>>>>.<<<<<<.<<<<.<<<<<<<<<<..<<<.<.<<<<..<...........>...>>>>.>.>>>...>>>>>>>.>>>...>>>>..>>>>.>>..<<<<<<<<<<..>>>>>>>>.>>....>>>>>>......>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<<<<...<<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<......>>>>>>>..<<<<<...<<<..<<<..[[[..((((>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>>.<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<....................<<<.<<<<<<<<<...<<<....<<<..<.<<<....<<<<.<....>.>>>>..>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.........>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<..<<.<<.........>>.....................>>..>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<..........))))..]]]......................................>>>>>>>>>....>>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<<....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<...........>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<...<<<<<<<....>>>>>>>...<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<...............>>>>><<.<<<<<<<<<<<.......................>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>...>>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<<.....>>>>>>>>...<<<<<.....<<<<..<.....<<<...>>.>...>...............<<<<<<<<<<.......>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>><<<<....>>>>>>)))].....<<<<<<<..<<<..)))))).>>>>>>>>>>.........>>>>..>>>>>>.......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<]]].>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.....<<<<<<<.<<..<<<<....<<<........<<<<<.<<<<....>>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>..............>>>>..>>>>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<....<<<<<......>>>>>...>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((...((((((((((.....)))))).)))).....)))....((((((((((...(((.((((...(....((((((((..({((((......)))))....[[(...).(((....}]])))...).))))))))..))).))))..))))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.(...(((((((((((..(((((((....(..((....((((.(((............))))))))).)....))))...))))))))))))))...)..))).))).)))))...(((((((((((((((((((((((...((..(((..(.((((......(((((((....))))))).......))))..))))........))))))..)))))))))))....................((((((.((((.((.......)).)))).((((((.((((.(((((((((((.((....((((....(........)....))))....)).).))))))).)))...))))..)))).))..((((((((((..)))))))).))....)))))).....))).)))))...)))))...)))))))).[((((........))))((((((....(((((((((((((..(((..(((((........))))..)..)))...((....))...(((((.(......).)))))..(((((...(((..(((...[....[[[)))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((....................(((.((((((((....(((....(((..(.(((..(.((((........))))).))).)..)))..)).)....))))))...(((((((((.(......))))))))))....))))))))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.....{.(...........................................)...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((..........]]]....]..........................(...)........)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((..(((((((...((.....)).))))))....[[(((.((...((....(((....)))..........((.((((.............))))))......))....))...(((((........)))))]]((((....(((((...(((((((....)))))))..((((....)))...(...((((((...(((((((((((((((((((((((..{{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....(((((((.......))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).))).))).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((.......................)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.(((((((((.((((((((.....))))))))...(((((.....((((.....((............))................((((((((((.......))))))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((.(.(..(((((...((.......))...)))))....)).).)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a.))..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}}.)))))..)).))...))))...)))).((((...((((.....}.......))))...))))..)))...).)))))).....((((((..((..((((.(..(((........(((((.((((....)))).))))).......)))...(((..((((....((((.(((((((......)))))))))))...))))..)))...........)..))))..)).))))))(((((.(..(.......)..)....((.(((((((.((.....((((.(..(((((......)))))..)))))....))....)))).))).))..))))).. Structure of human ribosome in classical-PRE state; 28S ribosomal RNA 6y0g L7 120 3.2 RF00001 URS000002B0D5_9606 32268098 0003735 0005840 9606 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((..((...(....)...))....))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. Structure of human ribosome in classical-PRE state; 5S rRNA 6y0g L8 156 3.2 RF00002 URS00004B2C76_9606 32268098 0003735 0005840 9606 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<.<<.....>>>.....(.<<<......>>.............>>>..)...>>>....<<....>><<<<<<<<<.....>>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))(((((((((.....))))))))).................... Structure of human ribosome in classical-PRE state; 5.8S ribosomal RNA 6y0g S2 1697 3.2 RF01960,RF01959,RF00177 URS0000868520_9606 32268098 0003735 0005840 9606 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucgacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgcccguggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuccgcgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggaggccucucggcgcccgaagcauuuacuuugaaaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgacccccgagcggucgcgucccccaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<......<<....<<<<<........<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<<......>>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<<...>>>>>>>>.>>.>>>...>>....>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>..>>>..>...>>.>.....<<.<<<<<<............>>.>>>>..>>.......<..<...........>..>..........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<..............................<<<<<<.<.......<<...<.......>.<<<<.......>>>>...>>......>.>>>..>>>........<.<<.<<<<<<<...............>>>>>>>.>>.>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<......>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<.......<<........>>..........<<<<<.<....<<<<<<.......<<.<<<........>>>.>>.....>>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<.......>>>>>>>>.....>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>>....>.>>>>>....>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<...<.<<<<<..........>>>>>>....>.....>>>>>.....<<<<<<<<.......>>>>>>>>.....>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<....<<<<....>.>>>......>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((....[[[..))))(((.((.(((.....((..((.....(((.(((..((.....(.....(..........)....).[))......(((.......(((.(.(..((....(((.....((...(......((.(((.....))).)).......)......)).((((...((((........))))...))))....(((((...(......)..))))).........(.((((.((((...)))))))))...)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.((............)).)).(.((....)).)...)))))).).....(.(((.....((.]...))...)))).)...)).......((...(.((............))..)....))....(.....(...........)..........)...((((.[......((((.....((..].)).......)))).))))...))).)).)))..[......(.([[...(.(.((...(((..(..............................((((((.........((..((.......)).(((.......)))....))........)))..)))........(.((.(....(.................)....).)).)....)....((..((...(...((((..((..((((((((...((........))......))))))))..)).......((....))...))))..)...))...)..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.((((......)))))))))).)..)))...((..]]))...))...].))))).).(((......((((....))))....)))...]]]...(.((.(((((((..((..(((((..(((.((((((......((........))..........((((..(....(((((.....(..(...((........))...)....).)))))...((.(((...(.((((((.(..(((.(((((....)))..(.((......)))...)).)))....(((...(...((((..(((((((.(..(.......)..).))).....))))..))))..).....(((((.....)))))........))).)..))).))).....).))))).....)..))))...)).)))).))).(....(.(((........(.......(((.((((....)))).)))....).........))).).......(......((((..........)).)).....)..)..))))).....((((((((.......)))))))).....))...)))))))))..)...(.(..((.(..((((.((..(.((((((((.(((...(((.((...((((.......................))))...)).)))...))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}........ Structure of human ribosome in classical-PRE state; 18S ribosomal RNA 6y2l A4 15 3.0 32268098 9606 uuuuuuuuuuuuuuu ............... ............... Structure of human ribosome in POST state; mRNA 6y2l B4 76 3.0 RF00005 URS00005AA258_9606 32268098 0030533 0006412 9606 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>><<<<<<<.....>>>>>>.>...<<<<<.......>>>>>>>>>>>>.... .((((((..((((.....[..)))).(((((.......))))).....((.((..]....)).))))))))..... Structure of human ribosome in POST state; tRNA 6y2l L5 3613 3.0 RF02543,RF02540 URS0000E60B81_9606 32268098 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcgguccggccgugucggcggcccggcggaucuuucccgcgcgggggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucgggggcccccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcgcucuccccccucccggggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccgggggggccacgcgcgcgucccccgagggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcagacccgaccgccacgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaagaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggcgcuaaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagcggcggcgcgcccggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcugggucggucgcggccggcgccuagcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacaaucguuuuuucacugacccggugaggcgggggggcgagccccgaggggcucucgcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccggucccccgccgggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..[[[...<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>...<<<<<<<<<<...<<<<<<<<........<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>...>>>>>>>>..>>>>>>>>>>.......<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<<<.<<<<<<<..<....<.....<<<<.<<<..<<......>>>>>>>>>.>...>..>>>>...>>>>>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<.<<<<<<<<<<<<<<<...<<..<<<.<<.<<<<......<<<<<<<....>>>>>>>.......>>>>.>>>>>........>>>>>>..>>>>>>>>>>>....................<<<<<..<<<<<<<....>>>>>>>.<<<<<<.<<<<.<<<<<<<<<<..<<<<..<<<<..<...........>...>>>>..>>>>...>>>>>>>.>>>...>>>>.>>>>.>>..<<<<<<<<<<..>>>>>>>>.>>.....>>>>>......>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<......>>>>>>>..<<<<<...<<<..<<<..((((.((((>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<...................<<<.<<<<<<<<<...<<<....<<<..<.<<<.....<<<........>>>...>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.........>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<........<<.<..<<....>>.....>.>>....>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<..........)))).))))................................>>>>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<<....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<...........>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<..<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..{{{..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<.<<<<<<<<<<<.......................>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>...>>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<<.<<<<<<<<........>>>>>>>>...<<<<<.....<<<<.........<.....>.....................<<<<<<<<<<.......>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>><<<<....>>>>>>)))]......((((((..(((..>>>>>>.)))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]].....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<.}}}..>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>......<<<<<..<<..<<<<....<<<........<<<<<.<<<<....>>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>..............>>>>..>>.>>>>>.<<<<<....................<<.<<<<<<<.<<.....<<<<....<<<<<......>>>>>...>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((...((((((((((.....)))))).)))).....)))....((((((((((...(((.((.....(....((((((((..({((((......)))))....[[(...).(((....}]])))...).))))))))....).))))..))))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....(((((((((((.(((.(((....(...(....((((.((....(......)..)))))))...)...)))....))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((.(..((((......(((((((....))))))).......))))..))))........))))))..)))))))))))......{.............((((((.((((.((....)).)))).((((((..(((.(((((((((((.((((..((((..................))))..)))).).))))))).)))...)))..)))).))..((((((((((..)))))))).))....)))))).....))).)))))...)))))...)))))))).<((((........))))((((((....(((((((((((((..(((..(((((........))))..)..)))...((....))...(((((.(......).)))))..(((((...(((..(((........[[[)))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((...................(((.((((((((....(((....(((..(.((((.(..(((........))).))))).)..)))..)).)....))))))...(((((((((.(......))))))))))....))))))))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.................................)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((........}.]]].........................(...)........)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((..(((((((...((.....)).))))))....[[(((.((...((....(((....)))..........((.(((((...........)))))))......))....))...(((((........)))))]]((((....(((((...(((((((....)))))))..((((....)))...(...((((((...(((((((((((((((((((((((..{{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....(((((((.......))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).))).))).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((.(((((((.......................)))))..)).))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.(((((((((.(((((((..........)))))))...(((((.....((((......(............).................(..((((((.........))))))..)..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a.))..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((.....(((....((.((((((.}}}..))))..)).))...)))....)))).(((....((((.............))))....)))..)))...).)))))).....(((((((.((..((((.(..(((........(((((.((((....)))).))))).......)))...(((..((((....((((.(((((((......)))))))))))...))))..)))...........)..))))..)))))))))(((((.(..(.......)..)....((.(((((((.((.....((.(.(..(((((......)))))..)).))....))....)))).))).))..))))).. Structure of human ribosome in POST state; 28S ribosomal RNA 6y2l L7 120 3.0 RF00001 URS000002B0D5_9606 32268098 0003735 0005840 9606 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....(((.((...(....)...)).)..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. Structure of human ribosome in POST state; 5S ribosomal RNA 6y2l L8 156 3.0 RF00002 URS00004B2C76_9606 32268098 0003735 0005840 9606 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<.<<.....>>>.....(.<<<......>>.............>>>..)...>>>....<<....>><<<<<<<<<.....>>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))(((((((((.....))))))))).................... Structure of human ribosome in POST state; 5.8S ribosomal RNA 6y2l S2 1713 3.0 RF01960,RF01959,RF00177 URS0000868520_9606 32268098 0003735 0005840 9606 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucgcacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgccccccguggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuccgcgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcgggcguccccgccccucucggcgcccgaagcauuuacuuugaaaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauucccaugacccgcgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgacccccgagcggucggcguccaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<....<<....<<<<<.........<<....<<<.<<.......>>.>>.>....>>.........<<<<...<<<<........>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<<......>>>>>>>>.>>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>..>>>..>...>>.>.....<<.<<<<<<............>>.>>>>..>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<........<..........>.......................<<<<<<.<.......<<...<.......>.<<<<.......>>>>...>>......>.>>>..>>>........<.<<.<<<<<<.................>>>>>>.>>.>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<.<<<<.<<<<......>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<......>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<........<<........>>..........<<<<<......<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<.......>>>>.>>>>..>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.......>>>>>......>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>............<<<<<..........>>>>>...........>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<......................>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))(((.((.(((...(.((..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..((....((((....((...........((.(((.....))).))..............)).((((....((..........))....))))((...((((...(......)..)))).......)).(.((((.((((......))))))))).).)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).).....((.(((.(..............)..)))..))......(...(...........)...).........((((([[......((((.....((..]])).......)))).)))))..))).)).)))..[......(.(.[...(.(.((...(((..(...........................................(((..(.(.......((..((.......)).(((.......)))....))......).)....)))........(.((.(.(...(...............)...).).)).)....)....(.(.((...(...((((..((..((((((((...((........))......))))))))..)).......((....))...))))..)...))..)...))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.((...(.(.((.(.(((........)))).))).)...))....(..].)....))...].))))).).(((......((((....))))....)))...]]].]((.((.(((((((..((..(((((..(((.((((((......((........))........(.(((((.(....((((......(..(..(((........)))..)....)..))))...((.(((...(.((((((.(..(((.(((((....)))..(.((......)))...)).)))....(((...(...((((..((((((((((((.......)))).))))..))))..))))..).....(((((.....)))))........))).)..))).))).....).))))).....).))))))..)).)))).))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....((((((((.......))))))))......))...)))))))))..))..(.(..((.(..((((.((..(.((((((((.(((..((((.((...((((((...................).)))))...)).))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}........ Structure of human ribosome in POST state; 18S ribosomal RNA 6y57 A4 13 3.5 32268098 9606 uuuuuuuuuuuuu ............. ............. Structure of human ribosome in hybrid-PRE state; mRNA 6y57 B4 75 3.5 RF00005 URS0000326EAC_9606 32268098 0030533 0006412 9606 agcagaguggcgcagcggaagcgugcugggcccauaacccagaggucgauggaucgaaaccauccucugcuacca <<<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... ((((.((..(((.........))).(((((.......))))).....(((((.......))))))).)))).... Structure of human ribosome in hybrid-PRE state; P/E tRNA 6y57 D4 73 3.5 RF00005 URS00005AA258_9606 32268098 0030533 0006412 9606 gcccggauagcucagggagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca ..<<<<...<<<<.....>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>.>>.>>..... .(..((...(...........)..((.(.......).))......((.............)).))..)..... Structure of human ribosome in hybrid-PRE state; A/P tRNA 6y57 L5 3574 3.5 RF02543,RF02540 URS0000E60B81_9606 32268098 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcggcccggcggaucuuucccgcgcgggggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucgggggcccccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcgcucuccccccucccgggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccgggggaggccacgcgcgcgucccccgagggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcagacccgaccgccacgcaguuuuauccgguaaagcgaaugauuagaggucuuggggcucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacccgcuaagcaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagcgcggcgcgcgccccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgaccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcuggguccggccggcgccuagcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagauuuuucacugacccggugaggcgggggggcgagccgggcucucgcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccggucccccgccgggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcuucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..[[[...<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>...<<<<<<<<<....<<<<<<<<........<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>...>>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<......>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<<<..<<<.<<<..<..........<<<<.<<<..<<......>>>>>>>>>.....>..>>>....>>>>>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<<<<<<<<<<<<.<<<<...<<..<<<....<<<<......<<<<<<<....>>>>>>>.......>>>>...>>>........>>>>>>...>>>>>>>>>>....................<<<<<..<<<<<<<...>>>>>>>.<<<<<<.<<<<.<<<<<<<<<<..<<<<<.<<<...<...........>....>>>.>>>>>...>>>>>>>.>>>...>>>>..>>>>.>>..<<<<<<<<<<..>>>>>>>>.>>.....>>>>>.....>>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<......>>>>>>>..<<<<<...<<<..<<<..(((...(((>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<...................<<<.<<<<<<<<<...<<<....<<<..<.<<<<....<.<.>.>..>>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.........>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<......<..........<<<.<<<<<<<<<<.......<<.<<............>>.>>...>>>>>>>>>>>>>..........))).>....>>>>>..>>>...>>>>>>><<<<<<.<<<..........)))...)))..........................>>>>>>>>>....>>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<.....>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<..<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..{{{..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<..................>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<<.<<<.<<.....>.>>>>...<<<<<.....<<<<..<.............>...............<<<<<<<<<<.......>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>>.<<<....>>>.>>)))]......((((((..(((..>>>>>>.)))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.<.....>.>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]].....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<}}}.>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.....<<<<<<<.<<..<<<<....<<<........<<<<<.<<<<....>>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>..............>>>>..>>>>>>>>><<<<<....................<<.<<<<<<<.<<.....<<<<....<<<<<...>>>>>...>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((...((((((((((.....)))))).)))).....)))....(((((((((....(((.((((...(....((((((((..({((((......)))))....[[(...).(((....}]])))...).))))))))..))).))))...)))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.((......(((((((((((..(((.(((........(....((((.((..............)))))).)......)))....)))))))))))))).......)).))).)))))...(((((((((((((((((((((((...((..(((..(.((((......(((((((....))))))).......))))..))))........))))))..)))))))))))....................((((((.((((((.....)))))).((((((.((((.(((((((((((.(((((.(((....................))).))))).).))))))).)))...))).).)))).))..((((((((((..)))))))).))....)))))).....))).)))))...)))))...)))))))).[((((........))))((((((....(((((((((((((..(((..((((..........)))..)..)))...((....))...(((((.(......).)))))..(((((...(((..(((..[[....[.[)))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((...................(((.((((((((....(((....(((..(.((((.............)))).)..)))..)).)....))))))...(((((((((.(......))))))))))....))))))))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.....{.((..(.............).))...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((...........]]....]].............(...)........)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((..(((((((...((.....)).))))))....[[(((.((...((....(((....)))..........((.(((.........)))))......))....))...(((((........)))))]]((((....(((((...(((((((....)))))))..((((....)))...(...((((((...(((((((((((((((((((((((..{{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....(((((((.......))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).))).))).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((...(.....)........)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.....((.....((((....)))).....))..))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.(((((((((.(...............)...(((((.....((((................................((((((((((.......))))))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))(.((...(((((((.(.((((((.......))))))...).((...[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(.(((((......)))))...).)..((.(.....).))......)))))..)...))).).....(((((((....))).))))..a.))..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}}.)))))..)).))...))))...)))).((((...((((.....}.......))))...))))..)))...).)))))).....(((((((.((..((((.(..(((........(((((.((((....)))).))))).......)))...(((...(((....((.(.(((((((......)))))))).))...)))...)))...........)..))))..)))))))))(((((.(..(.......)..)....((.(((((((.((.....((((....(((((...)))))...))))....))....)))).))).))..))))).. Structure of human ribosome in hybrid-PRE state; 28S ribosomal RNA 6y57 L7 120 3.5 RF00001 URS000002B0D5_9606 32268098 0003735 0005840 9606 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....(((.((...(....)...)).)..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. Structure of human ribosome in hybrid-PRE state; 5S ribosomal RNA 6y57 L8 156 3.5 RF00002 URS00004B2C76_9606 32268098 0003735 0005840 9606 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<.<<.....>>>.....(.<<<......>>.............>>>..)...>>>....<<....>><<<<<<<<<.....>>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))(((((((((.....))))))))).................... Structure of human ribosome in hybrid-PRE state; 5.8S ribosomal RNA 6y57 S2 1658 3.5 RF01960,RF01959,RF00177 URS0000868520_9606 32268098 0003735 0005840 9606 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucgacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuugggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgcccguggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauacaauacaggagcccuguaauuggaaugaguccacuuuaaauccuuccgcgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcgcccgccgcauuuacuuugaaaaaauuagaguguucaaagcaggcccccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuuuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgaccccgcggucggcgucaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggugcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<....<<....<<<<.........<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<.....>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<<...>>>>>>>>..>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>..>>>..>...>>.>....<<..<<<<<..>>.>>>...>>.......<..<...........>..>..........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<.....................<<<<<<.<.......<<...<.......>.<<<<....>>>>...>>......>.>>>..>>>........<.<<..<<<<<............>>>>>..>>.>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>.>.>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<<....>>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<......>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<.......<<........>>..........<<<<<......<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<....>>>>.>>>>.>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.......>>>>>....>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>............<<<<<..........>>>>>...........>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<...<<......>>.....>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((....[[[..))))(((.((.(((...(.((..(......(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..(.....(((.....((...((.....((.(((.....))).))......))......)).((((...((((.....))))...))))....(((((...(......)..))))).........(.((((.((((...)))))))))...)))....)).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).))...((....)).....)))))).......(.(((...((((.]...))).))))).)...)).)....((...(.((..))..)....).)......(.................)...........(((([[.......(((.....((..]])).......)))..))))...))).)).)))..[......(.([[...(.(.((...(((..(....(..........).....((((((.........((..((.......)).(((....)))....))........)))..)))..........((.(.(...................)).))......)....(((.((...(...((((..((..((((((((...((........))......))))))))..)).......((....))...))))..)...))..))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.((((......)))))))))).)..)))...((..]]))...))...].))))).).(((......((((....))))....)))...]]]..((.((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....((((((....(..((.(((........))).))....)))))))...((.(((...(.((((((.(..(((.(((((....)))..(.((......)))...)).)))....(((...(...((((..((((((((((((....)))).)))).))))..))))..).....(((((.....)))))........))).)..))).))).....).))))).....).)))))...)).)))).))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....(((((.((.......)).)))))......))...)))))))))..))..(.(..((.(..((((.((..(.((((((((.(((..((((.((...(((((....(......)......)))))...)).))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}........ Structure of human ribosome in hybrid-PRE state; 18S ribosomal RNA 6y69 a 1539 2.86 RF00177,RF01959,RF01960 URS000080DDC0_83333 32601485 0003735 0005840 83333 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<<....>>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.<...>.>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>.............>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((........))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))....(....)...))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Cryo-EM structure of an Escherichia coli 70S ribosome in complex with antibiotic TetracenomycinX; 16S ribosomal RNA 6y69 A 2887 2.86 RF02540,RF02541 URS0000B21DDD_83333 32601485 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugucgaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccgggagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggcguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccguaaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<....>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<.....<.........>.....>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<........>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<..<<....>>...>>>>>.>.....>>>>>>>>>..>>>>><<..>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<...<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<..<<...........<<<<....>>>>........>>............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>....>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<.<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>..>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((.(((((((((.(((...(((((......)))))[[......(((.....]])))...)))...))))))))).)))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((..((....))...))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.((....(............)...)).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((..........))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((....(((....])))....)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))((()))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((..(((((..(((((.(((.(((((.(((((((((((.((((.(.........(((((..((............(((....))).........))............)))))).)))).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..).))))......((((..(.((((((...((.......))...))))))...).)).).).....((.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..))....(..((((....))).)..)....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Cryo-EM structure of an Escherichia coli 70S ribosome in complex with antibiotic TetracenomycinX; 23S ribosomal RNA 6y69 B 120 2.86 RF00001 URS00008116C5_83333 32601485 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Cryo-EM structure of an Escherichia coli 70S ribosome in complex with antibiotic TetracenomycinX; 5S ribosomal RNA 6y69 w 74 2.86 RF00005 URS0000D77936_83333 32601485 0030533 0006412 83333 cgcgggguggagcaggguagcucgucuggcucauaaccagaagaucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((...[..)))).(((((.......))))).....(.(((..]....))).)))))))..... Cryo-EM structure of an Escherichia coli 70S ribosome in complex with antibiotic TetracenomycinX; E-site tRNA 6y6x L5 3773 2.8 RF02540,RF02543 URS000291569D_9606 32601485 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcggcccggcggaucuuucccgcgcgggggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucgggggcccccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcgcucuccccccucccggcgcgccggggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccgggggaggccacgcgcgcgucccccgaagagggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcagacccgacgcccgccacgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagcggcggcccggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcugggucggucgcggccggcgccuagcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacaugagagguguagaauaagugggaggcccccggcgcccccccgguguccccgcgaggggcccggggcgggguccgccggcccugcgggccgccggugaaauaccacuacucugaucguuuuuucacugacccggugaggcgggggggcgagccccgaggggcucucgcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccggucccccgccgggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>>..<<<<<<<<<<...<<<<<<<<........<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>...>>>>>>>>..>>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<<<..<<<<<<<...<<..<<....<<<<.<<<..<<<....>>>>>>>>>>>>..>>..>>>>...>>>>>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<.<<<<<<<<<<.<<<<...<<..<<<.<<.<<<<......<<<<<<<<..>>>>>>>>.......>>>>.>>>>>........>>>>>>...>>>>>>>>>>....................<<<<<<.<<<<<<<............>>>>>>>.<<<<<<.<<<<.<<<<<<<<<<<.<<<<..<<<<..<...........>...>>>>..>>>>.>.>>>>>>>.>>>...>>>>..>>>>.>>..<<<<<<<<<<.....>>>>>>>>.>>....>>>>>>......>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<......>>>>>>>..<<<<<...<<<..<<<..(((...(((>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<......................<<<.<<<<<<<<<...<<<....<<<..<.<<<.....<.............>...>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<..<.....................>.......................>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<..........)))...)))...<.....>..................>>>>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<.<.<....>>.>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<..<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<.<<<<<<<<<<<..<<..........>>.......>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>>.<<<<<.......>>>>>.........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<<..<<...............................................................................................................>>...>>>>>>>>...<<<<<.....<<<<........<<......>>...................<<<<<<<<<<.......>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>>.<<<....>>>.>>)))].....<<<<<<<..<<<..)))))).>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<]]].>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.....<<<<<<<.<<..<<<<....<<<........<<<<<.<<<<....>>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>..............>>>>..>>>>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<.<..<<<<<......>>>>>..>>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((...(((((((.((.....)).))).)))).....)))....((((((((((...(((.((((...(....((((((((..({((((......)))))....[[(...).(((....}]])))...).))))))))..))).))))..))))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....(((((((((((..(((((((...((..((....((((.(((...(.(..).).)))))))))..))..))))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((.(..((((......(.((((((())))))).).......))))..))))........))))))..)))))))))))...........[........((((((.((((((.....(.....)..)))))).((((((.((((.(((((((((((.((((..((((..................))))..)))).).))))))).)))...))))..)))).))..((((((((((.....)))))))).))..[.)))))).....))).)))))...)))))...)))))))).<((((........))))((((((....(((((((((((((..(((..(((((........))))..)..)))...((....))...(((((((......)))))))..(((((...(((..(((..[......[[)))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((......................(((.((((((((....(((....(((..(.(((..(..................).))).)..)))..)).)....))))))...(((((((((.(......))))))))))....))))))))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.....{.(((.(.................................(.(........).)..))))...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((..........]]......]]..(......)......]..........)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...((....(((....)))..........((.(((((...(....)..)))))))......))....))...(((((........)))))]]((((....(((((...(((((((....)))))))..((((....)))...(...((((((...(((((((((((((((((((((((..{{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....(((((((.......))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((...(([...)...])........)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.(.......((((.((((((..(((((.(((((((((.(((((((..........................................................................................................................)))))))...(((((.....((((.....(..............)................((((((((((.......))))))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a..)..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}}.)))))..)).))...))))...)))).((((...((((.....}.......))))...))))..)))...).)))))).....((((((..((..((((.(..(((........(((((.((((.(.))))).))))).......)))...(((..(((.....((((.(((((((......)))))))))))....)))..)))...........)..))))..)).))))))(((((.(..(.......)..)....((.(((((((.((.....((((.(..(((((......)))))..)))))....))....)))).))).))..))))).. Tetracenomycin X bound to the human ribosome; 28S ribosomal RNA 6y6x L7 120 2.8 RF00001 URS000002B0D5_9606 32601485 0003735 0005840 9606 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. Tetracenomycin X bound to the human ribosome; 5S ribosomal RNA 6y6x L8 156 2.8 RF00002 URS00004B2C76_9606 32601485 0003735 0005840 9606 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<<<<....>>>>.....<.<<<......>>.............>>>..>...>>>....<<....>><<<<<<<<<.....>>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))((((((((.......)))))))).................... Tetracenomycin X bound to the human ribosome; 5.8S ribosomal RNA 6yal 1 75 3.0 RF00005 URS0000326EAC_9986 32268096 0030533 0006412 9986 agcagaguggcgcagcggaagcgugcugggcccaunacccagaggucgauggaucgaaaccauccucugcuacca <<<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((...(((.......)))..(((((.......))))).....(((((.......)))))))))))).... Mammalian 48S late-stage initiation complex with beta-globin mRNA; initiator methionylated tRNA 6yal 2 1744 3.0 RF01960,RF01959,RF00177 URS0001A16A63_9986 32268096 0003735 0005840 9986 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgccuacuuggauaacugugguaauucuagagcuaauacaugccgacggcgcugacucccuuugugugggaugcgugcauuuaucagaucaaaaccaacccggucggcggcuuuggugacucuagauaaccucgggccgaucgcagcccuccguggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggucgcagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuuguggaggguuccccgccccuugccucucggcgccggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacncaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauucugugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagaugucggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggcccgccggggugcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<...[[[[>>>>>[[[.((((((.....{{.........[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[......{{....[[[.........<<.....<<.<<<.....>>>.>>......>>.........<<<...<<.<......>.>>...>>>.[[..(((((.....<<<<<<<<<<<<.....>>>....<......>..)))))......]]...<<<<.<<<......>>>.>>>>....]]]...}}....]]].<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<<...>>>>..>>>......}}.......<<<<<<.<<.<<<....>>>.>>..>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..)))))).]]]............{{.......{{...[[[.[[....<<<<.<<...>>>>>>........<......<<..>>....>....<<<<<<.<.......<<...<.......>.<<<<.......>>>>...>>......>.>>>..>>>.......[[....(((((((.....>>>>>>>>>.)))))))...]]....]]....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<..}}>>...>>.....>>>.....<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<......<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<<<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<....<<<..<<<<....>>>>.>>>....>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>...>.>>>>>>>......>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<.<<<<<<<<..>>>>>>>.>...>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((..((....((....((..........))...)){))......(((.......(((.(.(..((....(((.....{...((.....((.(((.....))).))......))..........((...((.(......).))...))..((..(((((.....[[[[[[[[[(((.....)))....(......)..)))))......)).(}((((.(((......))).)))))...)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)...)).).....(((.((.((.(((....))).))..))..)))....(.((..(...........)..))......)..((((([[....(.((((.....((..]])).......))))))))))..)))))).)))..{......(.({{...(.(.((...(((..(......((.(.....))).......((........((())).....))..((((((.(.......((..((.......)).(((.......)))....))......).)))..))).......((.(..(.(((((.....]]]]]]]]].))))).)..))..)..)....(((.((...(...((((..(((.((((((((...((........))......)))))))).))).......((....))...))))..)...))..))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..(.((((((.((((......)))))))))).)..)))...((..}}))...))...}.))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((.(.....(..((.(((........))).))....).).)))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((...(...((((..((((....(((.(.(((....)))).)))....))))..))))..)..(..(((((.....)))))....)...)))....))).))).....).))))).....))))))...)).)))).))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.....(((.((..(.((((((((.(((..((((.((...((((((((((.(((..))).))).).).)))))...)).))))..))).)))))))))..)).)))......))...)..)..(((((((((....)))))))))>........ Mammalian 48S late-stage initiation complex with beta-globin mRNA; 18S ribosomal RNA 6yal 3 42 3.0 32268096 9606 accucaaacagacaccauggugcaccugacuccugaggagaa .......................................... .......................................... Mammalian 48S late-stage initiation complex with beta-globin mRNA; beta-globin mRNA 6yam 1 75 3.6 RF00005 URS0000326EAC_9986 32268096 0030533 0006412 9986 agcagaguggcgcagcggaagcgugcugggcccaunacccagaggucgauggaucgaaaccauccucugcuacca <<<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((...(((.......)))..(((((.......))))).....(((((.......)))))))))))).... Mammalian 48S late-stage translation initiation complex (LS48S+eIF3 IC) with beta-globin mRNA; initiator methionylated tRNA 6yam 2 1743 3.6 RF01960,RF01959,RF00177 URS0001A16A63_9986 32268096 0003735 0005840 9986 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcuacuuggauaacugugguaauucuagagcuaauacaugccgacggcgcugacucccuuugugugggaugcgugcauuuaucagaucaaaaccaacccggucggcggcuuuggugacucuagauaaccucgggccgaucgcagcccuccguggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggucgcagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuuguggaggguuccccgccccuugccucucggcgccggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacncaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauucugugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagaugucggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggcccgccggggugcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<...[[[[>>>>>[[[.((((((.....{{.........[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[......{{....[[[........<<.....<<.<<<.....>>>.>>......>>.........<<<...<<.<......>.>>...>>>.[[..(((((.....<<<<<<<<<<<<.....>>>....<......>..)))))......]]...<<<<.<<<......>>>.>>>>....]]]...}}....]]].<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<<...>>>>..>>>......}}.......<<<<<<.<<.<<<....>>>.>>..>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..)))))).]]]............{{.......{{...[[[.[[....<<<<.<<...>>>>>>........<......<<..>>....>....<<<<<<.<.......<<...<.......>.<<<<.......>>>>...>>......>.>>>..>>>.......[[....(((((((.....>>>>>>>>>.)))))))...]]....]]....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<..}}>>...>>.....>>>.....<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<......<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<<<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<....<<<..<<<<....>>>>.>>>....>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>...>.>>>>>>>......>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<.<<<<<<<<..>>>>>>>.>...>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((..((....((....((..........))...)){))......(((.......(((.(.(..((....(((....{...((.....((.(((.....))).))......))..........((...((.(......).))...))..((..(((((.....[[[[[[[[[(((.....)))....(......)..)))))......)).(}((((.(((......))).)))))...)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)...)).).....(((.((.((.(((....))).))..))..)))....(.((..(...........)..))......)..((((([[....(.((((.....((..]])).......))))))))))..)))))).)))..{......(.({{...(.(.((...(((..(......((.(.....))).......((........((())).....))..((((((.(.......((..((.......)).(((.......)))....))......).)))..))).......((.(..(.(((((.....]]]]]]]]].))))).)..))..)..)....(((.((...(...((((..(((.((((((((...((........))......)))))))).))).......((....))...))))..)...))..))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..(.((((((.(((........))))))))).)..)))...((..}}))...))...}.))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((.(.....(..((.(((........))).))....).).)))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((...(...((((..((((....(((.(.(((....)))).)))....))))..))))..)..(..(((((.....)))))....)...)))....))).))).....).))))).....))))))...)).)))).))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.....(((.((..(.((((((((.(((..((((.((...((((((((((.(((..))).))).).).)))))...)).))))..))).)))))))))..)).)))......))...)..)..(((((((((....)))))))))>........ Mammalian 48S late-stage translation initiation complex (LS48S+eIF3 IC) with beta-globin mRNA; 18S ribosomal RNA 6yam 3 45 3.6 32268096 9606 gcaaccucaaacagacaccauggugcaccugacuccugaggagaa ............................................. ............................................. Mammalian 48S late-stage translation initiation complex (LS48S+eIF3 IC) with beta-globin mRNA; beta-globin mRNA 6yan 2 1744 3.48 RF01960,RF01959,RF00177 URS0001A16A63_9986 32268096 0003735 0005840 9986 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgccuacuuggauaacugugguaauucuagagcuaauacaugccgacggcgcugacucccuuugugugggaugcgugcauuuaucagaucaaaaccaacccggucggcggcuuuggugacucuagauaaccucgggccgaucgcagcccuccguggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggucgcagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuuguggaggguuccccgccccuugccucucggcgccggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacncaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauucugugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagaugucggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggcccgccggggugcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<...[[[[>>>>>[[[.((((((.....{{.........[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[......{{....[[[.........<<.....<<.<<<.....>>>.>>......>>........<<<<...<<.<......>.>>...>>>>[[..(((((.....<<<<<<<<<<<<.....>>>....<......>..)))))......]]...<<<<.<<<......>>>.>>>>....]]]...}}....]]].<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<<...>>>>..>>>......}}.......<<<<<<<<<.<<<....>>>.>>.>>>>.>>>......<<..<...........>..>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..)))))).]]]............{{.......{{...[[[.[[....<<<<.<<...>>>>>>........<......<<..>>....>....<<<<<<.<.......<<...<.......>.<<<<.......>>>>...>>......>.>>>..>>>.......[[....(((((((.....>>>>>>>>>.)))))))...]]....]]....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<<....>>>>>>>>>>>.>..>>>...<<..}}>>...>>.....>>>.....<<<......<<<......>>>....>>>..]]]]..<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<......<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<<<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<....<<<.<.<<<....>>>>.>>>....>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>...>.>>>>>>>......>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>............<<<<<..........>>>>>...........>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<.<<<<<<<<..>>>>>>>>....>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((..((....((....((..........))...)){))......(((.......(((.(.(..((....(((.....{...((.....((.(((.....))).))......))..........((...((.(......).))...))..((..(((((.....[[[[[[[[[(((.....)))....(......)..)))))......)).(}((((.(((......))).)))))...)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)...)).).....(((.((.((.(((....))).))..))..)))....(.((..(...........)..))......)..((((([[....(.((((.....((..]])).......))))))))))..)))))).)))..{......(.({{...(.(.((...(((..(......((.(.....))).......((........((())).....))..((((((.(.......((..((.......)).(((.......)))....))......).)))..))).......((.(..(.(((((.....]]]]]]]]].))))).)..))..)..)....(((..(...(...((((..(((.((((((((...((........))......)))))))).))).......((....))...))))..)...)...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..(.((((((.((((......)))))))))).)..)))...((..}}))...))...}.))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((...(...((((..((((....(((.(.(((....)))).)))....))))..))))..)..(..(((((.....)))))....)...)))....))).))).....).))))).....))))))...)).)))).))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((....((((.((..(.((((((((.(((..((((.((...((((((((((((((..))))))).).).)))))...)).))))..))).)))))))))..)).)))).....))...)..)..(((((((((....)))))))))>........ Mammalian 48S late-stage translation initiation complex with histone 4 mRNA; 18S ribosomal RNA 6yan 3 36 3.48 32268096 10090 ggucauaaccaugucuggacguggcaagggugguaa .................................... .................................... Mammalian 48S late-stage translation initiation complex with histone 4 mRNA; histone 4 (H4) mRNA 6yan 1 75 3.48 RF00005 URS0000326EAC_9986 32268096 0030533 0006412 9986 agcagaguggcgcagcggaagcgugcugggcccaunacccagaggucgauggaucgaaaccauccucugcuacca <<<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((...(((.......)))..(((((.......))))).....(((((.......)))))))))))).... Mammalian 48S late-stage translation initiation complex with histone 4 mRNA; initiator methionylated tRNA 6ybw A 1220 3.1 RF01960,RF01959,RF00177 URS0000726FAB_9606 32883864 0003735 0005840 9606 uaccugguugauccugccaguagcaunugcuugucucaaagauuaagccaugcaugucugaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuauggunccuunggucgcucgcuccuacuuggauaacugugguanuucuagngcuaauanaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgccccccguggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcnaauuacccacucccgacccgggganguagugangaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauancguauauuaaaguugcugcaguunaaaagcucguaguungaucuugggagcggccccgccccucucggcggcccgaagcguuuacuuugaaaaaanuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagancgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaaccgnccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccgggggcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucgnancaagguuuccguaggugnnccugcggaaggaucauua ...<<<<<...((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<....<<....<<<<<.............<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<........>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<<......>>>>>>>>.>>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<<..>>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....<......<<..<<....>>..>>.........>.....<<..<...........>..>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<....<<<.<.<..>.>.>>><<.<.........>.>>...<<<<<<.<.......<<...<.......>.<<<<.......>>>>...>>......>.>>>..>>>........<.<<.<<<.<.<...............>>..>>>.>>.>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>.>.>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<........>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..))))...<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<.......................>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((....[[[..))))(((.((((((...(.((..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..((....(((.....((....[...((.....((.(((.....))).))......))......)).((((...((((........))))...))))((..(((((...(......)..)))))......)).(]((((.(.((......)).))))))...)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).).....(......((.(((....))).))........)....(.((..(...........)..))......)..((((([[....(.((((.....((..]])).......))))))))))..)))))).)))..[......(.([[...(.(.((...(((..(.....((...(..)...)).((.............))...((((((.(.......((..((.......)).(((.......)))....))......).)))..)))........(.((.(.(.......................).).)).)....)....(((.((...(...((((..(((.((((((((...((........))......)))))))).))).......((....))...))))..)...))..))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.((((......)))))))))).)..)))...((..]]))...))...].))))).).(((......((((....))))....)))...]]].(.(..((.(..((((.((..(..(((((((.(((..((((.((...((((.(......................)))))...)).))))..))).))))))).)..)).))))...).))...)..)..(((((((((....)))))))))}........ Structure of a human 48S translational initiation complex - 40S body; 18S rRNA 6ybw 7 28 3.1 32883864 9606 aaaaaaaaaaaaaaaaaaaaaaaaaaaa ............................ ............................ Structure of a human 48S translational initiation complex - 40S body; mRNA 6ydp AA 960 3.0 RF02541,RF02540,RF00177,RF01959,RF00005,RF00005,RF00005,RF00005,RF00005,RF00005,RF00005,RF00005,RF00005,RF00005,RF00005,RF00005,RF00005,RF00005,RF00005,RF00005,RF00005,RF00005,RF00005 URS0001A24B67_9823 32602580 0003735,0030533 0006412 0005840 9823 acagguuugguccuggccuuucuauuaauucuuaauaaaauuacacaugcaaguauccgcgccccggugagaaugcccuccagaucuuaaagaucaaaaggagcagguaucaagcacaccuauaacgguagcucauaacgccuugcucaaccacacccccacgggaaacagcagugauaaaaauuaagccaugaacgaaaguuugacuaaguuauauuaauuagaguugguaaaucucgugccagccaccgcggucauacgauuaacccaaauuaauagauccacggcguaaagaguguuuaagaaaaaaaaucacaauagaguuaaauuauaacuaagcuguaaaaagcccuaguuaaaauaaaauaacccacgaaagugacucuaauaauccugacacacgauagcuaggacccaaacugggauuagauaccccacuaugccuagcccuaaacccaaauaguuacauaacaaaacuauucgccagaguacuacucgcaacugccuaaaacucaaaggacuuggcggugcuucacauccaccuagaggagccuguucuauaaucgauaaaccccgauagaccuuaccaacccuugccaauucagccuauauaccgccaucuucagcaaacccuaaaaaggaacaauaguaagcacaaucauagcacauaaaaacguuaggucaagguguagcuuauggguuggaaagaaaugggcuacauuuucuacauaagaauauccaccacacgaaaguuuuuaugaaacuaaaaaccaaaggaggauuuagcaguaaaucaagaauagagugcuugauugaauaaggccaugaagcacgcacacaccgcccgucacccuccucaagcauguaguaauaaaaauaaccuauauucaauuacacaaccaugcaagaagagacaagucguaacaagguaagcauacuggaaagugugcuuggauuacc ..((((..<<<<<<.)))).<<<<<<<<<..<<<<<<<<..<.<<<.<<<..<<....>>......<<.....<<<<<<...<<<<<...>>>>>...>>>.>>><<<....<<...<<<......>>>..>>......>>>..<.....>.>>.<<<....>>>.....>>>>>>>.........<<....<<<<....>>>>..>>...>>.>>>>>>...<.<<<<<<.....(((.....((.>>>)).......)))..>>>.>..>>>>>>>>>.....<<<((.....<<<<...<<..............<<<<<<.....<.<<<<<<.<<<......>>>..>>>>>>..>..........<<<....>>>>>>>>>......>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<......))...>>>>>>.>>>.<<<........<<....>>......>>>..>>>>>><<<<<.<<<<<<<...<<..<<<<<.<<<<<<<<<<<.....<<........>>..........<<<<<<<..........<<<.<<<..<<<<<<.......<<..<<<<<....>>>.......>>..>>......<<.....>>..........>>>...>>>>>>>>>...>>>>>>>..>>.>>>>>>>>.>...<<<<.....>>>>...........<....<<<<<<<......>>>>>>>....>.....>>>>>.....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<...<<<.<<..<<<<<..<<<<<...<<<.......>>>..>>>>>.....>>>>>..>>.>>>....>.>>...>.....<<<<<<<<<....>>>>>>>>>........ [.[[[[..(((((..]]]]](((((((((..((((((((..(.(((.(((..((....))......(((.....(((((...(((((...)))))...))).)).(((....((..((((......))).)))......)))..(.....)))).(((....))).....)))))))......(..((...(((((....)))).))).).)).))))))...(.((([[[.....(((.....((.]]])).......)))..))).)..))))))))).....((([[...(.((((...((..............(((((((......((((((.((........))..))))))......).....(.((....)))))))))......))...))))....((((((...((...((((.........))))...))))))))......{...(((((((.....]]..))))))))))).(((........((....))......)))...)))))(((((.(((((((...((..(((((..((((((((((.....((........))..........(((((((..(......).((.(((...((((((.(....((..(((((....))).......))..))......((.....))......).).)))...)).)))))....)))))))..)).)))))))).(...((((.....))))...........(....(((((((......)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(...(((.((..(((((..(((((...(((.......)))..))))).....)))))..)).)))....).))...)..)..(((((((((....)))))))))}....... 55S mammalian mitochondrial ribosome with mtEFG1 and P site fMet-tRNAMet (POST); 12S rRNA 6ydp AV 71 3.0 URS0000D77905_9606 32602580 9606 aguaaggucagcuaaauaagcuaucgggcccauaccccgaaaauguugguuauacccuucccguacuacca <<<<.<<..<<<<.....>>>>.<<<<<.......>>>>>....<..<<......>>..>>>.>>>>.... ((((.((..((((.....)))).(((((.......)))))....(..(........)..))).)))).... 55S mammalian mitochondrial ribosome with mtEFG1 and P site fMet-tRNAMet (POST); fMet-tRNAMet (P site) 6ydp BA 1544 3.0 RF02541,RF02540,RF00177,RF01959,RF00005,RF00005,RF00005,RF00005,RF00005,RF00005,RF00005,RF00005,RF00005,RF00005,RF00005,RF00005,RF00005,RF00005,RF00005,RF00005,RF00005,RF00005,RF00005 URS0001A24B67_9823 32602580 0003735,0030533 0006412 0005840 9823 accaaagcuagcucaacauacuaaacaaauacaaaaauacaccaaaauaaaauaaaacauucaccuaacauuaaaguauaggagauagaaauuuuuauccugacgcuauagagauaguaccguaagggaaagaugaaagaauaaaauaaaaguaaaaaaaagcaaagauuaccccuucuaccuuuugcauaaugguuuaaccagaaaaaaucuaacaaagagaacuuuagcuagauaccccgaaaccagacgagcuacccaugagcaguuuaaaagaaccaacucaucuauguggcaaaauagugagaagacuuguagguagaggugaaaagccuaacgagccuggugauagcugguuguccgagaaagaauuuuaguucaaccuuaaaaauaccccaaaaacccuaaauuccaauguauuuuuaagagauagucuaaaaagguacagcuuuuuagaaacggauacaaccuugacuagagaguaaaaucuuaauacuaccauaguaggccuaaaagcagccaucaauugagaaagcguuaaagcucaacaaauucaccaacauaaucccaaaaacuaauaacaaacuccuagcccaauaccggacuaaucuauugaaacauagaagcaauaauguuaauaugaguaacaagaagccuuucuccucgcacacgcuuacaucaguaacuaauaauauacugauaauuaacaaccaauaaaccaaaacaacacuaaaacguuuauuaauuacauuguuaacccaacacaggagugcaccaaggaaagauuaaaagaaguaaaaggaacucggcaaacacaaaccccgccuguuuaccaaaaacaucaccucuagcauuacuaguauuagaggcaaugccugcccagugacaccaguuuaacggccgcgguauucugaccgugcaaagguagcauaaucacuuguucuccaaauaaggacuuguaugaauggccacacgaggguuuuacugucucuuacuuccaaucagugaaauuaaccuucccgugaagaggcgggaauaaaaaaauaagacgagaagacccuauggagcuuuaauuaacuauuccaaaaguuaauaacuuaacauggacuagcaauuucgguuggggugaccucggaguacaaaaaacccuccgagugauuuuaaucuagacaaaccagucaaaauaaccauaacaucacuuauugauccaaaauuuugaucaacggaacaaguuacccuagggauaacagcgcaauccuguucuagaguuccuaucgacaauaggguuuacgaccucgauguuggaucaggacacccaaauggugcaaccgcuauuaaagguucguuuguucaacgauuaaaguccuacgugaucugaguucagaccggagcaauccaggucgguuucuaucuauuauaaauuucucccaguacgaaaggacaagagaaaugggaccaaccucacaaacgcgucucagagauaauuaaugauuuaaucuuaaccuaauuaacucauaauaaauccagcccuagaacagggcaca <<.<.....<<<<<.......................................<......>...........<.....<<.....>>....>.........>>.>>>............<<....>>...................>....>>...........<<<.......>>>...<.<........>.>..<<<<<........<<<<<.<..<<....>>...>.>>>>>..<<.<..<<<<<.<.....<<<.<<<<<..<<<......>>>...<<<..<<<<........>>>>.>>>....>>>>>.>>>...<<<.....>>>......>.>>>>...>..>.>>..<<<<<.....<<<<....>>>>..<<<<<<<<<<<<.....<<........>>.....>>>>>>>>>>>.>....<<<<<<<<<......>>>>>>>>>...<<......>>....<<<<.<<<........................<<<.........>>>............<<<......>>>........................................>>>>>>>........>>>>>...<<<<<......>>>>>.........>>>>>.<......<<..<<<....>>><<<..<<<<........<<<<<....<<....>>..>>>>>......<<<..<<<<<<<.................>>>>>>>.......>>>.....<<......>>.>>>>.....>>>..<<<<....<<<<<<<.<<...............<<<<<<<<..<<<.........>>>...<<<<<<.............>>>>>>...<<<<.<<<..<<<<<....>>>..>>>>><<<<<<......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>.>..>>.>>>>>>......>>.>>>>>>>.>>>>.>>.....>.....<<<<<........>>>>>.......<<<.<<<.<<......<<<<.<<<<<<..<<<<..<<<.<<<<.<<<<<<.>>>>>>....>>>>.>>>.>>>>..<<<<.....>>>><<<<<<...........>>>>>>.<<<<....<<...<<<......>>>...>>.........>>>>..........<<<....>>>............>>>>..>>>>>>.......<<<..<.<<<<<<...<<.......>>...>>>>>>...>.>>.>.......<<<<<.<<<<<<..<<.<<<<<<......>>>>>>...>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>>>>.<<.<<<<<<<.................>>>>>>><<<<<...<.........>.>>>>>.<<<.<.<<<<.................>>>>..>>>>.>>.........<<<<.......>>>>... ((.(...(..((((.......................................(...[..)........(..(.....((.]...))....)..)......)).)).............((....))....)..............)....))...........(((.......))).[.(.(........).)..(((((........(((((.(..((....))...).)))))..((.(...((((.(.....(((.((((((.(((.....[)))...(((..((((.......{)))).)))..).))))).))).(.(((.....)))...)..).))))......).))..(((((.....((((....))))...(((((((((((.....((........)).....)))))))))))......(((((((((......)))))))))...((......))....((((.(((...................(.(..(((.........)))..).)....(..(((......)))).......................................)))))))........)))))...(((((......))))).........))))).(......((..((((..))))(((..((((......(.(((((....((....))..)))))......(((..(((((((...........(..)..))))))).......))).)...((......)).)))).....)))..((((....(((((((.((..(....(.......((((((((.].((.........))....((((((.............))))))....(((.(((..(((((....)))..)))))(((((........)))))........((..........(((((.......)))))..)..)....)))....)).))))))..)..))).))))))).)))).)).....)..{..(((((.....]}.))))).......(((.(((.((......((((.((((((..((((..(((.((((.(((((.())))))....)))).))).))))..(((......[)))((((((..........]))))))((((((..)((.(.(((...[..))))..)).........))))..........(((....))).....)].....))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......((((.((((((..((.((((((......))))))...)).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..}.))..)))))).((.(((((((......(....).....)))))))(((((...(.(.....).).))))).(((....(((.................)))....))).)).........((((.......))))... 55S mammalian mitochondrial ribosome with mtEFG1 and P site fMet-tRNAMet (POST); 12S rRNA 6ydw AA 960 4.2 RF02541,RF02540,RF00177,RF01959,RF00005,RF00005,RF00005,RF00005,RF00005,RF00005,RF00005,RF00005,RF00005,RF00005,RF00005,RF00005,RF00005,RF00005,RF00005,RF00005,RF00005,RF00005,RF00005 URS0001A24B67_9823 32602580 0003735,0030533 0006412 0005840 9823 acagguuugguccuggccuuucuauuaauucuuaauaaaauuacacaugcaaguauccgcgccccggugagaaugcccuccagaucuuaaagaucaaaaggagcagguaucaagcacaccuauaacgguagcucauaacgccuugcucaaccacacccccacgggaaacagcagugauaaaaauuaagccaugaacgaaaguuugacuaaguuauauuaauuagaguugguaaaucucgugccagccaccgcggucauacgauuaacccaaauuaauagauccacggcguaaagaguguuuaagaaaaaaaaucacaauagaguuaaauuauaacuaagcuguaaaaagcccuaguuaaaauaaaauaacccacgaaagugacucuaauaauccugacacacgauagcuaggacccaaacugggauuagauaccccacuaugccuagcccuaaacccaaauaguuacauaacaaaacuauucgccagaguacuacucgcaacugccuaaaacucaaaggacuuggcggugcuucacauccaccuagaggagccuguucuauaaucgauaaaccccgauagaccuuaccaacccuugccaauucagccuauauaccgccaucuucagcaaacccuaaaaaggaacaauaguaagcacaaucauagcacauaaaaacguuaggucaagguguagcuuauggguuggaaagaaaugggcuacauuuucuacauaagaauauccaccacacgaaaguuuuuaugaaacuaaaaaccaaaggaggauuuagcaguaaaucaagaauagagugcuugauugaauaaggccaugaagcacgcacacaccgcccgucacccuccucaagcauguaguaauaaaaauaaccuauauucaauuacacaaccaugcaagaagagacaagucguaacaagguaagcauacuggaaagugugcuuggauuacc ..((((..<<<<<<.)))).<<<<<<<<<..<<<<<<<<..<.<<<.<<<..<<....>>......<<......<<<<<...<<<<<...>>>>>...>>>.>>.<<<....<<...<<<......>>>..>>......>>>..<.....>.>>.<<<....>>>.....>>>>>>>.........<<....<<<<....>>>>..>>...>>.>>>>>>...<.<<<<<<.....(((.....((.>>>)).......)))..>>>.>..>>>>>>>>>.....<<<((.....<<<<...<<..............<<<<<<.....<.<<<<<<.<<<......>>>..>>>>>>..>..........<<<....>>>>>>>>>......>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<......))...>>>>>>.>>>.<<<........<<....>>......>>>..>>>>>><<<<<.<<<<<<.....<..<<<<<..<<<<<<<<<<.....<<........>>..........<<<<<<<..........<<<.<<<..<<<<<<.......<<..<<<<<....>>>.......>>..>>......<<.....>>..........>>>...>>>>>>>>>...>>>>>>>..>>.>>>>>>>>.....<<<<.....>>>>...........<....<<<<<<<......>>>>>>>....>.....>>>>>.....<<<<<<<.........>>>>>>>......>.....>>>>>>>>>.>>....<..<<.<...<<<.<<..<<<<<..<<<<<...<<<<.....>>>>..>>>>>.....>>>>>..>>.>>>....>.>>...>.....<<<<<<<<<....>>>>>>>>>........ [.[[[[...((((..]]]]].((((((((..((((((((..(.(((.(((..((....))......(((.....(((((...(((((...)))))...))).)).(((....((..((((......))).)))......)))..(.....)))).(((....))).....)))))))......(..((...(((((....)))).))).).)).))))))...(.((([[[.....(((.....((.]]])).......)))..))).)..))))))))......((([[...(.((((...((..............(((((((......((((((.(((......)))..))))))......).....(.((....)))))))))......))...))))....((((((...((...((((.........))))...))))))))......{...(((((((.....]]..))))))))))).(((........((....))......)))...)))).(((((.((((((.....(..(((.(..((((((((((.....((........))..........(((((((..(......).((.(((...((((((.(........(((((....))).......))..........((.....))......).).)))...)).)))))....)))))))..)).)))))))).(...((((.....))))...........(....(((((((......)))))))....)..)..).))).....(((((((.........)))))))......).....))))))))).))..(.(..((.(...(((.((..(((((..(((((...(((.......)))..))))).....)))))..)).)))....).))...)..)..(((((((((....)))))))))}....... 55S mammalian mitochondrial ribosome with mtEFG1 and two tRNAMet (TI-POST); 12S rRNA 6ydw AV 71 4.2 URS0000D77905_9606 32602580 9606 aguaaggucagcuaaauaagcuaucgggcccauaccccgaaaauguugguuauacccuucccguacuacca <<<<.<<..<<<<.....>>>>.<<<<<.......>>>>>.......<<......>>...>>.>>>>.... ((((.((..((((.....)))).(((((.......)))))....(..((......))..))).)))).... 55S mammalian mitochondrial ribosome with mtEFG1 and two tRNAMet (TI-POST); tRNAMet 6ydw AY 71 4.2 URS0000D77905_9606 32602580 9606 aguaaggucagcuaaauaagcuaucgggcccauaccccgaaaauguugguuauacccuucccguacuacca <<<<.<...<<<<.....>>>>.<<<<<.......>>>>>.......<<......>>....>.>>>>.... ((((.((..((((.....)))).(((((.......)))))....(..((......))..))).)))).... 55S mammalian mitochondrial ribosome with mtEFG1 and two tRNAMet (TI-POST); tRNAMet 6ydw BA 1544 4.2 RF02541,RF02540,RF00177,RF01959,RF00005,RF00005,RF00005,RF00005,RF00005,RF00005,RF00005,RF00005,RF00005,RF00005,RF00005,RF00005,RF00005,RF00005,RF00005,RF00005,RF00005,RF00005,RF00005 URS0001A24B67_9823 32602580 0003735,0030533 0006412 0005840 9823 accaaagcuagcucaacauacuaaacaaauacaaaaauacaccaaaauaaaauaaaacauucaccuaacauuaaaguauaggagauagaaauuuuuauccugacgcuauagagauaguaccguaagggaaagaugaaagaauaaaauaaaaguaaaaaaaagcaaagauuaccccuucuaccuuuugcauaaugguuuaaccagaaaaaaucuaacaaagagaacuuuagcuagauaccccgaaaccagacgagcuacccaugagcaguuuaaaagaaccaacucaucuauguggcaaaauagugagaagacuuguagguagaggugaaaagccuaacgagccuggugauagcugguuguccgagaaagaauuuuaguucaaccuuaaaaauaccccaaaaacccuaaauuccaauguauuuuuaagagauagucuaaaaagguacagcuuuuuagaaacggauacaaccuugacuagagaguaaaaucuuaauacuaccauaguaggccuaaaagcagccaucaauugagaaagcguuaaagcucaacaaauucaccaacauaaucccaaaaacuaauaacaaacuccuagcccaauaccggacuaaucuauugaaacauagaagcaauaauguuaauaugaguaacaagaagccuuucuccucgcacacgcuuacaucaguaacuaauaauauacugauaauuaacaaccaauaaaccaaaacaacacuaaaacguuuauuaauuacauuguuaacccaacacaggagugcaccaaggaaagauuaaaagaaguaaaaggaacucggcaaacacaaaccccgccuguuuaccaaaaacaucaccucuagcauuacuaguauuagaggcaaugccugcccagugacaccaguuuaacggccgcgguauucugaccgugcaaagguagcauaaucacuuguucuccaaauaaggacuuguaugaauggccacacgaggguuuuacugucucuuacuuccaaucagugaaauuaaccuucccgugaagaggcgggaauaaaaaaauaagacgagaagacccuauggagcuuuaauuaacuauuccaaaaguuaauaacuuaacauggacuagcaauuucgguuggggugaccucggaguacaaaaaacccuccgagugauuuuaaucuagacaaaccagucaaaauaaccauaacaucacuuauugauccaaaauuuugaucaacggaacaaguuacccuagggauaacagcgcaauccuguucuagaguuccuaucgacaauaggguuuacgaccucgauguuggaucaggacacccaaauggugcaaccgcuauuaaagguucguuuguucaacgauuaaaguccuacgugaucugaguucagaccggagcaauccaggucgguuucuaucuauuauaaauuucucccaguacgaaaggacaagagaaaugggaccaaccucacaaacgcgucucagagauaauuaaugauuuaaucuuaaccuaauuaacucauaauaaauccagcccuagaacagggcaca <<.<.....<<<<<.......................................<......>...........<.....<<.....>>....>.........>>.>>>............<<....>>...................>....>>...........<<<.......>>>...<.<........>.>..<<<<<........<<<<<.<..<<....>>...>.>>>>>..<<.<..<<<<<.<.....<<<.<<<<<..<<<......>>>...<<<..<<<<........>>>>.>>>....>>>>>.>>>...<<<.....>>>......>.>>>>...>..>.>>..<<<<<.....<<<<....>>>>..<<<<<<<<<<<<.....<<........>>.....>>>>>>>>>>>.>....<<<<<<<<<......>>>>>>>>>...<<......>>....<<<<.<<<........................<<<.........>>>............<<<......>>>........................................>>>>>>>........>>>>>...<<<<<......>>>>>.........>>>>>.<......<<..<<<....>>><<<..<<<<........<<<<<....<<....>>..>>>>>......<<<..<<<<<<<.................>>>>>>>.......>>>.....<<......>>.>>>>.....>>>..<<<<....<<<<<<<.<<...............<<<<<<<<..<<<.........>>>...<<<<<<.............>>>>>>...<<<<.<<<..<<<<<....>>>..>>>>><<<<<<......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>.>..>>.>>>>>>......>>.>>>>>>>.>>>>.>>.....>.....<<<<<........>>>>>.......<<<.<<<.<<......<<<<.<<<<<<..<<<<..<<<.<<<<.<<<<<<.>>>>>>....>>>>.>>>.>>>>..<<<<.....>>>><<<<<<...........>>>>>>.<<<<....<<...<<<......>>>...>>.........>>>>..........<<<....>>>............>>>>..>>>>>>.......<<<..<.<<<<<<...<<.......>>...>>>>>>...>.>>.>.......<<<<<.<<<<<<..<<.<<<<<<......>>>>>>...>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>>>>.<<.<<<<<<<.................>>>>>>><<<<<...<.........>.>>>>>.<<<.<.<<<<.................>>>>..>>>>.>>.........<<<<.......>>>>... ((.(...(..((((.......................................(...[..)........(..(.....((.]...))....)..)......)).)).............((....))....)..............)....))...........(((.......))).[.(.(........).)..(((((........(((((.(..((....))...).)))))..((.(...((((.(.....(((.((((((.(((.....[)))...(((..((((.......{)))).)))..).))))).))).(.((.......))...)..).))))......).))..(((((.....((((....))))...(((((((((((.....((........)).....)))))))))))......(((((((((......)))))))))...((......))....((((.(((.....................(..(((.........)))..)......(..(((......)))).......................................)))))))........)))))...(((((......))))).........))))).(......((..((((..))))(((..((((......(.(((((....((....))..)))))......(((..(((((((...........(..)..))))))).......))).)...((......)).)))).....)))..((((....(((((((.((..(....(.......((((((((.].((.........))....((((((.............))))))...((((.(((..(((((....)))..)))))(((((........)))))........((..........(((((.......)))))..)..)....))).)..)).))))).).)..))).))))))).)))).)).....)..{..(((((.....]}.))))).......(((.(((.((......((((.((((((..((((..(((.((((.(((((.())))))....)))).))).))))..(((......[)))((((((..........]))))))((((((..)((.(.(((...[..))))..)).........))))..........(((....))).....)].....))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......((((.((((((..((.((((((......))))))...)).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..}.))..)))))).((.(((((((......(....).....)))))))(((((...(.(.....).).))))).(((.....((.................)).....))).)).........((((.......))))... 55S mammalian mitochondrial ribosome with mtEFG1 and two tRNAMet (TI-POST); 12S rRNA 6yef a 1545 3.2 RF00177,RF01959,RF01960 URS00019B8AE6_93061 32852796 0003735 0005840 93061 uggagaguuugauccuggcucaggaugaacgcuggcggcgugccuaauacaugcaagucgagcgaacggacgagaagcuugcuucucugauguuagcggcggacgggugaguaacacguggauaaccuaccuauaagacugggauaacuucgggaaaccggagcuaauaccggauaauauuuugaaccgcaugguucaaaagugaaagacggucuugcugucacuuauagauggauccgcgcugcauuagcuaguugguaagguaacggcuuaccaaggcaacgaugcauagccgaccugagagggugaucggccacacuggaacugagacacgguccagacuccuacgggaggcagcaguagggaaucuuccgcaaugggcgaaagccugacggagcaacgccgcgugagugaugaaggucuucggaucguaaaacucuguuauuagggaagaacauauguguaaguaacugugcacaucuugacgguaccuaaucagaaagccacggcuaacuacgugccagcagccncgguaauacguagguggcaagcguuauccggaauuauugggcguaaagcgcgcguaggcgguuuuuuaagucugaugugaaagcccacggcucaaccguggagggucauuggaaacuggaaaacuugagugcagaagaggaaaguggaauuccauguguagcggugaaaugcgcagagauauggaggaacaccaguggcgaaggcgacuuucuggucuguaacugacgcugaugugcgaaagcguggggaucaaacaggauuagauacccugguaguccacgccguaaacgaugagugcuaaguguuaggggguuuccgccccuuagugcugcagcuaacgcauuaagcacuccgccuggggaguacgaccgcaagguugaaacucaaaggaauugacggggacccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaaaucuugacauccuuugacaacucuagagauagagccuuccccuucgggggacaaagugacagguggugcaugguugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuuaagcuuaguugccaucauuaaguugggcacucuaaguugacugccggugacaaaccggaggaagguggggaugacgucaaaucaucaugccccuuaugauuugggcuacacacgugcuacaauggacaauacaaagggcagcgaaaccgcgaggucaagcaaaucccauaaaguuguucucaguucggauuguagucugcaacucgacuacaugaagcuggaaucgcuaguaaucguagaucagcaugcuacggugaauacguucccgggucuuguacacaccgnccgucacaccacgagaguuuguaacacccgaagccgguggaguaaccuuuuaggagcuagccgucgaaggugggacaaaugauuggggugaagucguaacaagguagccguaucngnnggugcggcuggaucaccucc ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<<<....<<..........>>....>>>>.>>>>>......<<........<<<<<<<..<<...<<<<<<<.<<<<.....<<<<<<....>>>>>>......>>>>......<<<<<<<<<....>>>>>>>>>......<<<<<<...>>>>>>.>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<.......<<<....>>>......>>>>....<<<<<<.........................................>>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<<..<<<.<<<<<<<.<<<<<<<<<.......<<<<<<.....>>>>>>.....>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<.<.<<<......>>>.....>>>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>..>>>>>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<<....>>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<.<<<......<<<<<....>>>>>.....<<<<..>>>>...>>.>.>..<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<..<<<......>>>>>...>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<..<<<<....<.<<<<..<<<..<<<...>>>.>>>.>>>>.>...>>>>..>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>........... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((.....(((........))).....))).)))))......(((.......(((((((..((...(((((((.(.((......(..((....))..).......)).)............(((....)).)...........(((.((...)).))).)))))))..))))))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....((((((.........................................))))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))...).)))))))..)))))))))..(.(.(((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))))..)...))))...))))....((((((....(...((((.........))))...).))))))......{...((((((..((((((((((((......))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(......(.......((..(....)..))......((....)).....).....).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..((......)))))...)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((..((((....(.((((..(((..(((...))).))).)))).)...))))..))))))..))).))))..).))...)..)..(((((((((....)))))))))}.......... 70S initiation complex with assigned rRNA modifications from Staphylococcus aureus; 16S rRNA 6yef v 21 3.2 32852796 32630 aggagguaaaaaugguaaaaa ..................... ..................... 70S initiation complex with assigned rRNA modifications from Staphylococcus aureus; mRNA 6yef A 2881 3.2 RF02540,RF02541,RF00002 URS00001C3329_93061 32852796 0003735 0005840 93061 uuaaguuauuaagggcgcacgguggaugccuuggcacuagaagccgaugaaggacguuacuaacgacgauaugcuuuggggagcuguaaguaagcuuugauccagagauuuccgaauggggaaacccagcaugaguuaugucauguuaucgauaugugaauacauagcauaucagaaggcacacccggagaacugaaacaucuuaguacccggaggaagagaaagaaaauucgauucccuuaguagcggcgagcgaaacgggaagagcccaaaccaacaaguuguugggguuguaggacacucggaguuacaaaggacgacauuagacgaaucaucuggaaagaugaaucaaagaagguaauaauccuguagucgaaaauguugucucucuugaguggauccugaguacgacggagcacgugaaauuccgucggaaucugggaggaccaucuccuaaggcuaaauacucucuagugaccgauagugaaccaguaccgugagggaaaggugaaaagcaccccggaaggggagugaaauagaaccugaaaccgugugcuuacaaguagucagagcccguuaaugggugauggcgugccuuuuguagaaugaaccggcgaguuacgauuugaugcaagguuaagcaguaaauguggagccguagcgaaagcgagucugaauagggcguuuaguauuuggucguagacccgaaaccaggugaucuacccuuggucagguugaaguucagguaacacugaauggaggaccgaaccgacuuacguugaaaagugagcggaugaacugaggguagcggagaaauuccaaucgaaccuggagauagcugguucucuccgaaauagcuuuagggcuagccucaagugaugauuauuggagguagagcacuguuuggacgaggggccccucggguaccgaauucagacaaacuccgaaugccaauuaauuuaacuugggagucagaacaugggugauaagguccguguucgaaagggaaacagcccagaccaccagcuaaggucccaaaauauauguuaaguggaaaaggauguggcguugcccagacaacuaggauguuggcuuagaagcagccaucauuuaaagagugcguaauagcucacuagucgagugacacugcgccgaaaauguaccggggcuaaacauauuaccgaagcuguggauuguccuggacaaugguaggagagcguucuaagggcguugaagcaugaucguaaggacauguggagcgcuuagaagugagaaugccggugugaguagcgaaagacgggugagaaucccguccaccgauugacuaagguuuccagaggaaggcucguccgcucuggguuagucggguccuaagcugaggccgacaggcguaggcgauggauaacagguugauauuccuguaccaccuauaaaucgauggggggacgcaguaggauaggcgaagcgugcgauuggauugcacgucuaagcaguaaggcugaguauuaggcaaauccgguacucguuaaggcugagcugugauggggagaaguucgagucguugauuucacacugccgagaaaagccucuagauagaaaauaggugcccguaccgcaaaccgacacagguagucaagaugagaauucuaaggugagcgagcgaacucucguuaaggaacucggcaaaaugaccccguaacuucgggagaaggggugcucuuuaggguuaacgcccagaagagccgcagugaauaggcccaagcgacuguuuaucaaaaacacaggucucugcuaaaccguaaggugauguauaggggcugacgccugcccggugcuggaagguuaagaggagugguuagcuucugcgaagcuacgaaucgaagccccaguaaacggcggccguaacuauaangguccuaagguagcgaaanuccuugucggguaaguuccgacccgcacgaaaggcguaacgauuugggcacugucucaacgagagacucggugaaaucauaguaccugugaagaugcagguuacccgcgacaggacggaaagaccccguggagcuuuacuguagccugauauugaaauucggcacagcuuguacaggauagguaggagccuuugaaacgugagcgcuagcuuacguggaggcgcuggugggauacuacccuagcuguguuggcuuucuaacccgcaccacuuaucguggugggagacagugucaggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcucaaagguucccucagaaugguuggaucauucauagaguguaaaggcauaagggagcuugacugcgagaccuacaagucgagcagggucgaaagacggacuuagugauccggugguuccgcauggaagggccaucgcucaacggauaaaagcuaccccgnggauaacaggcuuaucucccccaagaguucacaucgacggggagguuuggcancucgnugucggcucaucgcauccuggggcuguagucggucccaaggguugggcuguucgcccauuaaagcgguacgcgagcuggguucagaacgucgugagacaguucggucccuauccgucgugggcguaggaaauuugagaggagcuguccuuaguacgagaggaccgggauggacauaccucugguguaccaguugucgugccaacggcauagcuggguagcuauguguggacgggauaagugcugaaagcaucuaagcaugaagccccccucaagaugagauuucccaacugguuauaagaucccucaaagaugaugagguuaauagguucgagguggaagcauggugacauguggagcugacgaauacuaaucgaucgaagacuuaau <<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<<<<<<<<.........>>>>>>>.>>.>>....<<<<<......<<....>>.......>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..(((....<<<<<<<.>>>>>>>......<<<<<<<<<<<<<.......<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>.>>>>>..>>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<....>>>>..................>>>>>>>>>>>.......<<<<..<<<<......>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<.<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>.>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<...<<<<<<<<<.....<<<...<<<<<<<<...<<...<.....>...>>...>>>>>>>>..>>.>.....>>>>>.>>>>..>>>>>>>.>>..<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<.<<<<........<<.....<...<<...........>>...>..........................>>....>>>>.>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<.>>>>>>>....>>>>>><.<<<<<<<.<<......<<<<<.<<....>>.>>>>>...>>.>>>>>>>..>.....>>>>>><......<<....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<.<.<<<...<<<....>>>...>>>..>>>...<<<<<........>>>>>))<<<<<<<..<<<...<<<<....<<<<..<<...<<<<<.<.<<<.....{...>>>.>.<....<<<<...<<<.<<<<<<..<<.....>>.>>>>>>......>>>...>>>>.....>............>>>>>....>>...>>>>.........>>>>..>>>.....>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<.......>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<<.<<<<....>>>>.>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<<.<<....>>..>>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<<.<<<<.<<<...<.<<<...........<<<<<..<<<......<<<.<<<......>>>.>>>...>>>............>>>>>..>>>.>...>>>.>>>>....<<.<<<<<<.....>>>>>>>>.....>>>>>>>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.....>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<..}...>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>.<<<..>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>. ((((((......((((((((((.....(((..(((((((((((((......((((((.[[..[[[)))...].((((((...(((]]..]].)))......))))))...)))....(((....)))(((((((......))))))).(((((((((.........))))))).)).))....(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((((((.)))))))....[.(((((((((((((........(((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))))))).)))).)))))..)))))....(((((((...{.......)))))))....].(((((}.[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((..((((..[...))))..)))).<.(.(........).).((((((....(((((((.(((((..(((...(((.....)))...)))...((....))..((((.....)))).....))))).)))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...).)))...(((.(((((.......A))))))))..).))))))))).(.(((....[)))...).]))))))......).))..((((((....(((((....)))))(((((((((...(((((((((.....(((...((((((((...((.............))...))))))))..)).).....))))).))))..))))))).))..((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((.(((((.....{.(....(..(...(...........)...)............(......)....)...)...))))).)))).))...........]]].)...))))))))))...)))))))(((((((.)))))))....))))))(.(((((((.((......(((((.((....))])))))...)).)))))))..).....))))))(......((....((((((.......))))))((((....(((...((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]]((((((....((...((((....(((((.((...(((((...........{.........((....(((.......(((((((.((.....)))))))))............))).....)).....().....)))))....))..)))))(..).....))))..)).......)))))))))).))).....((......))..))).(((.......)))..))))..((((....((((((((.((..(....(.......(((((....(.[..).....)))))(((((((.((((....)))).)))))))(...).......(((((((((...((.........))...(((((((.....(((....))).......))))))).]((((.(((..(((((((..(((...((...(((((..((....))...)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).[..(((((.....>].)))))..((((((((.(((.((......((((.((((((..(((((.(((((((((.((((.(((.....((................(..(((........(..............).....))).............)......)).....))).))))....((.((((((.....)))))))).....)))))))))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.......)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..a.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}..))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))((((..)))....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))...))))))). 70S initiation complex with assigned rRNA modifications from Staphylococcus aureus; 23S rRNA 6yef B 115 3.2 RF00001 URS0000062A7E_93061 32852796 0003735 0005840 93061 ucuggugacuauagcaaggaggucacaccuguucccaugccgaacacagaaguuaagcuccuuagcgucgaugguagucgaacuuacguuccgcuagaguagaacguugccaggc <<<<<<<<<....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<......<<<.<<<<....>>>>.>>>......>>..>>>>>>>>>. .((((((((....((((((((.....((((((...(.....)...))))..))....)))))).)).((.......((.((((....)))).)).......))..)))))))).. 70S initiation complex with assigned rRNA modifications from Staphylococcus aureus; 5S rRNA 6yef x 77 3.2 RF00005 URS000041AF00_668369 32852796 0030533 0006412 668369 cgcggggnggagcagccuggnagcucgucgggnucauaacccgaagnucgucggnucaaauccggcccccgcaaccn .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(((((.......)))))))))))..... 70S initiation complex with assigned rRNA modifications from Staphylococcus aureus; P-site tRNA 6yhs 1 2672 2.7 RF02540,RF02541 URS0000211949_575584 32857965 0003735 0005840 575584 gucaaguaauuaagugcaugugguggaugccuuggcagucagaggcgaugaaagacgugauagccugcgaaaagcuccggggaggcggcaaauauccuuugauccggagaugucugaaugggggaacccaccuacuuuaagguagguauugcaacaugaauacauaguguugcaaggcgaacgaggggaagugaaacaucucaguacccuuaggaaaagaaaucaauugagauucccucaguagcggcgagcgaacggggaucagcccauuaaguuauguguguuuuaguggaacgcucugggaagugcgaacguagagggugauauucccguacacgaaagggcacacauaaugaugacgaguagggcgaggcacgugaaaccuugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccugugaggggagugaaauagauccugaaaccgcaugcauacaagcagugggagcaccuuuguggugugacugcguaccuuuuguauaaugggucagcgacuuauauucaguagcgagguuaaccguauaggggagccguagagaaaucgagucuuaauagggcguuuaguugcuggguauagacccgaaaccaggcgaucuauccaugagcagguugaagguuggguaacacuaacuggaggaccgaacccacugucguugaaaagccaggggaugacuuguggauaggggugaaaggcuaaucaagccuggugauagcugguucuccccgaaagcuauuuagguagcgccucggacgaauaccauaggggguagagcacuguuucggcuaaccgaugcaaacuccgaauaccuaugaguacuauccgggagacagacugcgggugcuaacguccguagucaagaggaaaacaauccagaccgccagcuaaggccccaaaaucauaguuaagugggaaacgaugugggaaggcaagucggccugcgcggaagauguaacggggcuaaaacuaugugccgaagcugcggauguauacuuuguauacgugguaggggagcguucuguaagccgaugaagguguguugagaagcaugcuggagguaucagaagugcgaaugcugacgugaguaacgacaaaacgggugaaaaacccguucgccgaaagaccaaggguuccaguccaacguuaaucggggcugggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaaaugguuaauauuccauuacuucuguguaaugcgaugagaggacggagaaggcuaaaucagccuggcguugguuguccaggugaaaggauguaggcauguaucuuaggcaaauccgggguacucuaugcugagaucugaaagugguugaugccaugcuuccaggaaaagucucuaagcuucaguuacacaggaaucguacccgaaaccgacacagguggucaggucgaguagaccaaggcgcuugagagaacucugcugaaggaacuaggcaaaaugguaccguaacuucgggagaagguacgcuguuguuggugauugagcugacgacagccgcagaaaccaggccgcugcaacuguuuauuaaaaacauagcacucugcaaacacgaaaguggacguauagggugugaugccugcccggugcuggaagguuaauugaugggguuagcguaagcgaagcucuugaucgaagccccaguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcauaaugauggcggcgcugucuccagcagaggcucagugaaaucgaaaucgcugugaagaugcaguguacccgcggcuagacggaaagaccccgugaaccuuuacugcagcuugacacugaacugguucuaacucugucccgugauccgggacgaggaccgugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggaguacgaaggugcgcucagcguggucggaaaucacgcguagaguauaaaggcaaaagcgcgcuuaacugcgagacccacaagucgagcagguacgaaaguaggucuuagugauccggugguucuguauggaagggccaucgcucaacggauaaaagguacucuggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucucauccuggggcugaagcaggucccaaggguauggcuguucgccauuuaaagagguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucuaccgugggcgcuggaaauuugagaggaucugcuccuaguacgagaggaccagaguggacgaaccucugguguaccgguugugacgccagucgcaucgccggguagcuauguucggaagggauaaccgcugaaagcaucuaagcgggaagccuaccucaagauaagauuucccuaggacuuuauguccucuaaagagccguucgagacuaggacguugauagguuggauguggaagcauagugauaugugaagcugaccaauacuaauugcucgugaggcuugacu 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(((((((......((((((((((.....(((..(((((((((((((......((((((....[[[.))).....((((((...((.]]]......))......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.....((((((((((((((.(((...(((.(......).)))[[(...).(((.....]])))...)))...))))))))))))))......)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((.....)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((.(.......<).))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).(((((((....(((((((((.....(((...(((.((((....)))).)))..)).).....)))))).)))...)))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((...........((..(((((..(((..)))..))))).))...........]]]......))))))))))...)))))))((((((((...))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((.(...((((....((((..(((..((((((((((((...{{{.).))))))....(((....((((.(((((((.((.....)))))))))....))))....))).....)))))...)))...))))(..).....))))...).....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((......))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..(((((((..(((.((......(((..((((((..(((((.(((.(((((.((((..))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..)).)))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))..>.))..))).)))))))[...(((((((...((((..((((((......(....).....)))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.((((((..).)))))(....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))..).)))))))). Acinetobacter baumannii ribosome-amikacin complex - 50S subunit; 23S ribosomal RNA 6yhs 5 115 2.7 RF00001 URS0000143D25_575584 32857965 0003735 0005840 575584 gcuggcgaccauagcaagagugaaccaccugaucccuucccgaacucagaagugaaaccucuuagcgcugaugguagugugggauuacccaugugagaguaagucaucgccagcu <<<<<<<<.....<<<<<<<.....<<<<<<...............>>>..>>>....>>>>>.>><<<.......<<<<<<<....>>>>>>>.......>>>..>>>>>>>>. (.((((((.....(((((((.....(((((((...(.....)...))))..)))....))))).))(((.......(((((((....))))))).......)))..)))))).). Acinetobacter baumannii ribosome-amikacin complex - 50S subunit; 5S ribosomal RNA 6yl5 A 26 1.7 URS0001A24B6D_1907202 32520325 1907202 ggunacaacggcuuccuggcgugacc <<<<<<..............>>>>>> ((((((..(........)..)))))) Crystal structure of the SAM-SAH riboswitch with SAH; Chains: A,B,C,D,E,F,G,H,I,J,K,L 6yl5 C 26 1.7 URS0001A24B6D_1907202 32520325 1907202 ggunacaacggcuuccuggcgugacc <<<<<<..............>>>>>> ((((((..(........)..)))))) Crystal structure of the SAM-SAH riboswitch with SAH; Chains: A,B,C,D,E,F,G,H,I,J,K,L 6yl5 E 26 1.7 URS0001A24B6D_1907202 32520325 1907202 ggunacaacggcuuccuggcgugacc <<<<<<..............>>>>>> ((((((..(........)..)))))) Crystal structure of the SAM-SAH riboswitch with SAH; Chains: A,B,C,D,E,F,G,H,I,J,K,L 6yl5 G 26 1.7 URS0001A24B6D_1907202 32520325 1907202 ggunacaacggcuuccuggcgugacc <<<<<<..............>>>>>> ((((((..(........)..)))))) Crystal structure of the SAM-SAH riboswitch with SAH; Chains: A,B,C,D,E,F,G,H,I,J,K,L 6yl5 I 26 1.7 URS0001A24B6D_1907202 32520325 1907202 ggunacaacggcuuccuggcgugacc <<<<<<..............>>>>>> ((((((..(........)..)))))) Crystal structure of the SAM-SAH riboswitch with SAH; Chains: A,B,C,D,E,F,G,H,I,J,K,L 6yl5 K 26 1.7 URS0001A24B6D_1907202 32520325 1907202 ggunacaacggcuuccuggcgugacc <<<<<<..............>>>>>> ((((((..(........)..)))))) Crystal structure of the SAM-SAH riboswitch with SAH; Chains: A,B,C,D,E,F,G,H,I,J,K,L 6ylb A 26 2.12 URS0001A24B50_1907202 32520325 1907202 ggunacaacggcuuccuggcgugacc <<<<<<..............>>>>>> ((((((..(........)..)))))) Crystal structure of the SAM-SAH riboswitch with SAM; Chains: A,C,F,I,M,O 6ylb C 26 2.12 URS0001A24B50_1907202 32520325 1907202 ggunacaacggcuuccuggcgugacc <<<<<<..............>>>>>> ((((((..(........)..)))))) Crystal structure of the SAM-SAH riboswitch with SAM; Chains: A,C,F,I,M,O 6ylb F 26 2.12 URS0001A24B50_1907202 32520325 1907202 ggunacaacggcuuccuggcgugacc <<<<<<..............>>>>>> ((((((..(........)..)))))) Crystal structure of the SAM-SAH riboswitch with SAM; Chains: A,C,F,I,M,O 6ylb I 26 2.12 URS0001A24B50_1907202 32520325 1907202 ggunacaacggcuuccuggcgugacc <<<<<<..............>>>>>> ((((((..(........)..)))))) Crystal structure of the SAM-SAH riboswitch with SAM; Chains: A,C,F,I,M,O 6ylb M 26 2.12 URS0001A24B50_1907202 32520325 1907202 ggunacaacggcuuccuggcgugacc <<<<<<..............>>>>>> ((((((..(........)..)))))) Crystal structure of the SAM-SAH riboswitch with SAM; Chains: A,C,F,I,M,O 6ylb O 26 2.12 URS0001A24B50_1907202 32520325 1907202 ggunacaacggcuuccuggcgugacc <<<<<<..............>>>>>> ((((((..(........)..)))))) Crystal structure of the SAM-SAH riboswitch with SAM; Chains: A,C,F,I,M,O 6ylg 1 3039 3.0 RF02540,RF02543 URS000061F377_4932 32668200 0003735 0005840 4932 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..........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<.<<<<<.<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>>..>>>>>>.....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<...<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<......>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<......<<......>>..<<<<<<<<<....<<<.<<<<<<..<<<....<.<....<<.<<.....>>>>..>..>.>>>..>>>>...<<<<.<<<....>>>.>>>>.>>>>>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<......<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>....>>>>>>.>>>>..>>>>>>><<<<<<<<<...>>>>>>>>>....>>>>>><.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<.>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>...<...<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>...>......>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<.>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>.......<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<.<...>.>>>...............>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.....[[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<<<<<<<<<..........<<<<<......................>>>>>.>>>>>>>.>>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>........................<<<<<<<...<<<<<<.......>>>>>>.....<<...((>>....>>>>>>>...<<<..<<<<....>>>>..>>>.<<<....>>>...)).((((((..((((.>>>>>>))))))))))...]]]]..}}]]]]]........<<<<<<...<<.......>>...>>>>>>...............<<<<...<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>.......>>>>...<<<<<<<....>>>.>>>>........}}}.]]]]]....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>..<........<.......<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>..............>...........><<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<.>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. 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Rix1-Rea1 pre-60S particle - 60S core, body 1 (rigid body refinement); 25S rRNA 6ylg 2 154 3.0 RF00002 URS00001BF64E_4932 32668200 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaaugugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauu .........................................<<<<<<.<<.....>>>.....(.<<<......>>...........>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>.................... .........................................((((((.[[.....))).....(.((((.....]].........).)))..)...)))....((.....))(((((((((....))))))))).................... Rix1-Rea1 pre-60S particle - 60S core, body 1 (rigid body refinement); 5.8S rRNA 6ylg 3 117 3.0 RF00001 URS000055688D_4932 32668200 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggcauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<....<<<.<<<............>>>....>>...>>>>>>>.>><<<<<<.......<<<<<.......>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......((.((..(..).)).)).....))))))))))))))). 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..........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<.<<<<<.<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>>..>>>>>>.....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<...<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<......>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<......<<......>>..<<<<<<<<<....<<<.<<<<<<..<<<....<.<....<<.<<.....>>>>..>..>.>>>..>>>>...<<<<.<<<....>>>.>>>>.>>>>>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<......<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>....>>>>>>.>>>>..>>>>>>><<<<<<<<<...>>>>>>>>>....>>>>>><.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<.>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>...<...<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>...>......>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<.>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>.......<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<.<...>.>>>...............>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.....[[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<<<<<<<<<..........<<<<<......................>>>>>.>>>>>>>.>>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>........................<<<<<<<...<<<<<<.......>>>>>>.....<<...((>>....>>>>>>>...<<<..<<<<....>>>>..>>>.<<<....>>>...)).((((((..((((.>>>>>>))))))))))...]]]]..}}]]]]]........<<<<<<...<<.......>>...>>>>>>...............<<<<...<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>.......>>>>...<<<<<<<....>>>.>>>>........}}}.]]]]]....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>..<........<.......<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>..............>...........><<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<.>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ..........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((.(((.(((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..).))).))....)))))))))))...)....(.(((((........))))).).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((..(((((((((((((((((((((((.......(((((((......((((((....)))))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((.......<))))((((((..(.((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......A)))).)))....))))))))).(.((.......))...)..))))))......).))).((((((......(((....)))..(((((.(((....(((.((((((..((............(..((.....))..).......))..))))...((((.(((...).)).)))).)))))))).))).))..((((.((.((.....)).)).))))....(((......)))...(((((((...((([[[...(.(((((.......(...........((.((((((((((.....{.(((((.(.(...((.........))...).).....(...((......)).).)))))...))))))))))))...........]]].).....)))))))))...)))))))(((((((((...)))))))))....))))))((((((((((.((......((((.((((....))))))))...)))))))))).)).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........((((((.))))))....))....))...(((((........)))))]]((((.((((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((..{{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....))))..)))))))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((.)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.....(....((((((.(...((.....((((....)))).....)).)))))..))..).(..(...)..)................)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.....(((((.((((((..(((((.(((.((((..((((((((((.((((((.......[...(.((....................].)).)..))))))..))))))))))....((((.....((((...(((........)))............>...((((((....))))))..))))..))))......)))).)))..))))).......................((((((((.(.((((((.......))))))...).((...[.))....))))))))..(((..((((....))))..))).(((....)))....].(((((...((((.]]]]]])))).)))))...))))..)))))))...[.....(((((...((.......))...)))))................(((...(((((..(.(((((((......))))))..).).(.(.(.....).).).....)))))..].>..)))...(((.(((....)))..)))..a.....))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}}.)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....))))))))...((..............((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).))))))......................).)..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(((((.)))))..)))))...)))....)))).)))))).))))).. Rix1-Rea1 pre-60S particle - full composite structure; 25S rRNA 6ylh 2 154 3.1 RF00002 URS00001BF64E_4932 32668200 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaaugugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauu .........................................<<<<<<.<<.....>>>.....(.<<<......>>...........>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>.................... .........................................((((((.[[.....))).....(.((((.....]].........).)))..)...)))....((.....))(((((((((....))))))))).................... Rix1-Rea1 pre-60S particle - full composite structure; 5.8S rRNA 6ylh 3 117 3.1 RF00001 URS000055688D_4932 32668200 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggcauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<....<<<.<<<............>>>....>>...>>>>>>>.>><<<<<<.......<<<<<.......>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......((.((..(..).)).)).....))))))))))))))). Rix1-Rea1 pre-60S particle - full composite structure; 5S rRNA 6ylx 1 2534 3.9 RF02540,RF02543 URS000061F377_4932 32668200 0003735 0005840 4932 guuugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaaacuuuaaauauguaagaagucggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugauuuauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggggcuuggcagaaucagcggggaaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggagugagcuggguuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ...........................<<<<<.....<<....>>......>>>>>.....<.....<<....>>..<<<<<......<<.....>>.....>>>>>..<<<...........<<.<<<<<<...>>>>>>.>>.............<<<<<<.<<<<<<<<<<<<<<<<<<<<<.....<<<<......>>>>.(.......<<<......)>>>....>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....<<<<<........>>>>>..>>>....>.............................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<......<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<......>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<.....<<<.<<<<<<.........................>>>>...<<<.>>>.....>>>>>...>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<......<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>....>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><<.<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>..>>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<<<<<<<<<<<<..(((..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<<....>>>>>>>>>>>>.>.>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<...............>>>>><<.<<<<<<<<<<....>>>>..>>>>>>.>>............<<<<<<<....<<<.........>>>..<...>.................>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<....>>>>>....<<<<<..<<.............<<<<<<...<<.......>>...>>>>>>......................<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>>..............>>.>>>>>....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<....<<<...<<<<<<<<<<<))).>>>>>..>>>>>>..>>>...>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<........>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ..........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))))....)))))))))))...)....(.(((((........))))).)......((((........))))...)))..................................((....))............(..((((....))))............).....................(((((.(((((......(((((((((((((((((((((((.......(((((((......((((.(....).)))).......))))))).....))))).))))))))))........(((....)))....)))))))).....))))).)))))..((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...){)))...(((..((.((........)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)(((.((...(...(((.(((((.........(........)........)))...(((.))).....)))))...)..))).))..((((.((.((.....)).)).))))....(((......)))...(((((((...((([[[...(.(((((.......(...........((.((((((((((.....<.(((((.(.(...(...........)...).).........((......))...)))))...))))))))))))...........]]].).....)))))))))...)))))))((((((((...........))))))))....))))))(.((((((((.((.......(((.((((....)))))))....))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...((((((...((.....)).))))))....[[(((.((...((....(((....)))........((((((........))))))....))....))....((((........)))).]]((((.((((((((...((((....)))...(...((((((...((((.((((((((((((((((((..[[[..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....))))..)))))))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((..........)..)))))).))(...).......(((((((.(.}.((.........))...(...).]............)..))))))).)..))).)))))))..))))))....)).[..(((((..].)))))....(((((..((...............((((...((.......))...))))...................(((..((((((..(.(((((((......))))))..).).(((.........))).....))))))....))).......)).)))))....(((.((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((]]].)))))..)))))...))))..))))).((((...((.(.....>.......).))...)))).))))....)))).))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(((..(..)....)))..)))))...)))....)))).)))))).))))).. pre-60S State NE1 (TAP-Flag-Nop53); 25S rRNA 6ylx 2 158 3.9 RF00002 URS00001BF64E_4932 32668200 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... pre-60S State NE1 (TAP-Flag-Nop53); 5.8S rRNA 6ylx 6 65 3.9 URS000013305B_4932 32668200 4932 ccuucucaaacauucuguuugguagugagugauacucuuuggaguuaacuugaaauugccuuaaa ......<<<<<<...>>>>>>.....<<<<...<<<<....>>>>..>>>>.............. .......((((.....)))).....(((((...((((....))))..))))..)........... pre-60S State NE1 (TAP-Flag-Nop53); ITS2 6yly 1 2676 3.8 RF02540,RF02543 URS000061F377_4932 32668200 0003735 0005840 4932 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucucacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagaauauguaagaaguccgacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugacaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuuauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaaggggcuuggcagaaucagcggggacuaguuugacauugugaagagacauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucaggugguagucccucggaauuugaggcuaaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggauacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[...........<<.<<<<<<...>>>>>>.>>.............<<<<<<<.<<<<<<<<<<<<<<<<<<<<.....<<<<......>>>>.(.......<<<......)>>>....>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<......<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<...>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<......<<<....>>><.<<<<<<<<<<...<<<.<<<<<<<......>>>>>...<<<.>>>.....>>>>>.>>>>>>>>.>>>.<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<......<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>....>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><<.<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>..>>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<.<....>>>>....>>....>>>..<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>...<.{{<<<<<<...<<<<.<<<<<<<<<<<<<<<<<<..[[[..>>>>>>....<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>.....<<<<<<<<....>>>>>>>>>>>>.>.>>>>>>>.>>>>.........>>>>>>...>......>>>..>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<....<....>.....>>>>><<.<<<<<<<<<<<..>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>.<.<.....>.>..>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<...>>>>>....(((((..[[[....<<<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>..........}}...<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..[[[..((((.>>>>>>))))]]]............<<<<<...<<.......>>...>>>>>................(.......<<<<<..<.<<<<<<<......>>>>>>>...>.<<<....)....>>>.....>>>>>...]]].)))))....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<....<<<....<<<<<<<<<.]]]..>>>>..>>>>>...>>>...>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<.....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>..............>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<.<.....>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))))....)))))))))))...)....(((((((........)))))))......((((..[[[[[[))))...)))..................................((....))............(..((((....))))............).....................(((((.(((((......(((((((((((((((((.(((((.......(((((((......((((.(....).)))).......))))))).....)))))..)))))))))........(((....)))....)))))))).....))))).)))))..((((...))))((((((....(.(((..((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....))))))..))).)..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)<)))...(((..(..((........)).).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)(((.((((((....((.(((((((......)))))...(((.))).....))))..)))))).).))..((((.(((((.....))))).))))....(((......)))...((((((....((([[[.....((((((......(..........(((.((((((((((.....{..((((.(.(...(...........)....)).........((......))...))))....)))))))))))))..........]]].)....)))))).)))....))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....))).........(((.....))).....))....))...(((((........)))))]]((((..(((((((...((((....)))...(.[[((((((...((((.(((.((((..((((.((...{{{...)).))(...(((((....(((((.....(((.....))).....))))).....)))))....).(((((((....))))))).))...).))).))).))))(...)....))))))...))....))))..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(....).....)))))((.(((((((((((..)))))..)))))).))(...).......(((((((((.>.((.........))....((((((....((((.....))))......))))))....(.....)....)).))))))).)..))).)))))))..))))))....)).[..(((((.].)))))....(((((..(((....((.(((((..(..(((((((...)))))))..)....((((.....((((..(((..........)))..........]]...((((((....))))))..))))..))))......))))).))..(((..((((.]]]]]]))))))).............((((...((.......))...)))).........................(((((..(.(.((((........))))...).).(((.........))).....)))))...))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}}.)))))..)))))...))))..))))).((((...((.(.....}.......).))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((.(.(..(((......)))..).).))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((.(((.(((....((((.(..(((..(.....).)))..)))))...)))....)))..)))))).))))).. pre-60S State NE2 (TAP-Flag-Nop53); 25S rRNA 6yly 3 158 3.8 RF00002 URS00001BF64E_4932 32668200 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.(((......]]..............)))..)...)))....((.....))(((((((((....)))))))))..................... pre-60S State NE2 (TAP-Flag-Nop53); 5.8S rRNA 6ymi A 25 2.5 URS0001A24B50_1907202 32520325 1907202 gguacaacggcuuccuggcgugacc <<<<<..............>>.>>> (((((..(........)..)).))) Crystal structure of the SAM-SAH riboswitch with AMP.; Chains: A,C,F,I,M,O 6ymi C 25 2.5 URS0001A24B50_1907202 32520325 1907202 gguacaacggcuuccuggcgugacc <<<<<..............>>.>>> (((((..(........)..)).))) Crystal structure of the SAM-SAH riboswitch with AMP.; Chains: A,C,F,I,M,O 6ymi F 25 2.5 URS0001A24B50_1907202 32520325 1907202 gguacaacggcuuccuggcgugacc <<<<<..............>>.>>> (((((..(........)..)).))) Crystal structure of the SAM-SAH riboswitch with AMP.; Chains: A,C,F,I,M,O 6ymi I 25 2.5 URS0001A24B50_1907202 32520325 1907202 gguacaacggcuuccuggcgugacc <<<<<..............>>.>>> (((((..(........)..)).))) Crystal structure of the SAM-SAH riboswitch with AMP.; Chains: A,C,F,I,M,O 6ymi M 25 2.5 URS0001A24B50_1907202 32520325 1907202 gguacaacggcuuccuggcgugacc <<<<<..............>>.>>> (((((..(........)..)).))) Crystal structure of the SAM-SAH riboswitch with AMP.; Chains: A,C,F,I,M,O 6ymi O 26 2.5 URS0001A24B50_1907202 32520325 1907202 ggunacaacggcuuccuggcgugacc <<<<<<..............>>>>>> ((((((..(........)..)))))) Crystal structure of the SAM-SAH riboswitch with AMP.; Chains: A,C,F,I,M,O 6ymj A 26 2.04 URS0001A24B50_1907202 32520325 1907202 ggunacaacggcuuccuggcgugacc <<<<<<..............>>>>>> ((((((..(........)..)))))) Crystal structure of the SAM-SAH riboswitch with adenosine.; Chains: A,C,F,I,M,O 6ymj C 25 2.04 URS0001A24B50_1907202 32520325 1907202 gguacaacggcuuccuggcgugacc <<<<<..............>>.>>> (((((..(........)..)).))) Crystal structure of the SAM-SAH riboswitch with adenosine.; Chains: A,C,F,I,M,O 6ymj F 26 2.04 URS0001A24B50_1907202 32520325 1907202 ggunacaacggcuuccuggcgugacc <<<<<<..............>>>>>> ((((((..(........)..)))))) Crystal structure of the SAM-SAH riboswitch with adenosine.; Chains: A,C,F,I,M,O 6ymj I 26 2.04 URS0001A24B50_1907202 32520325 1907202 ggunacaacggcuuccuggcgugacc <<<<<<..............>>>>>> ((((((..(........)..)))))) Crystal structure of the SAM-SAH riboswitch with adenosine.; Chains: A,C,F,I,M,O 6ymj M 26 2.04 URS0001A24B50_1907202 32520325 1907202 ggunacaacggcuuccuggcgugacc <<<<<<..............>>>>>> ((((((..(........)..)))))) Crystal structure of the SAM-SAH riboswitch with adenosine.; Chains: A,C,F,I,M,O 6ymj O 25 2.04 URS0001A24B50_1907202 32520325 1907202 gguacaacggcuuccuggcgugacc <<<<<..............>>.>>> (((((..(........)..)).))) Crystal structure of the SAM-SAH riboswitch with adenosine.; Chains: A,C,F,I,M,O 6ymk A 26 2.03 URS0001A24B50_1907202 32520325 1907202 ggunacaacggcuuccuggcgugacc <<<<<<..............>>>>>> ((((((..(........)..)))))) Crystal structure of the SAM-SAH riboswitch with AMP; Chains: A,C,F,I,M,O 6ymk C 26 2.03 URS0001A24B50_1907202 32520325 1907202 ggunacaacggcuuccuggcgugacc <<<<<<..............>>>>>> ((((((..(........)..)))))) Crystal structure of the SAM-SAH riboswitch with AMP; Chains: A,C,F,I,M,O 6ymk F 26 2.03 URS0001A24B50_1907202 32520325 1907202 ggunacaacggcuuccuggcgugacc <<<<<<..............>>>>>> ((((((..(........)..)))))) Crystal structure of the SAM-SAH riboswitch with AMP; Chains: A,C,F,I,M,O 6ymk I 26 2.03 URS0001A24B50_1907202 32520325 1907202 ggunacaacggcuuccuggcgugacc <<<<<<..............>>>>>> ((((((..(........)..)))))) Crystal structure of the SAM-SAH riboswitch with AMP; Chains: A,C,F,I,M,O 6ymk M 26 2.03 URS0001A24B50_1907202 32520325 1907202 ggunacaacggcuuccuggcgugacc <<<<<<..............>>>>>> ((((((..(........)..)))))) Crystal structure of the SAM-SAH riboswitch with AMP; Chains: A,C,F,I,M,O 6ymk O 26 2.03 URS0001A24B50_1907202 32520325 1907202 ggunacaacggcuuccuggcgugacc <<<<<<..............>>>>>> ((((((..(........)..)))))) Crystal structure of the SAM-SAH riboswitch with AMP; Chains: A,C,F,I,M,O 6yml A 26 2.17 URS0001A24B50_1907202 32520325 1907202 ggunacaacggcuuccuggcgugacc <<<<<<..............>>>>>> ((((((..(........)..)))))) Crystal structure of the SAM-SAH riboswitch with decarboxylated SAH; Chains: A,C 6yml C 26 2.17 URS0001A24B50_1907202 32520325 1907202 ggunacaacggcuuccuggcgugacc <<<<<<..............>>>>>> ((((((..(........)..)))))) Crystal structure of the SAM-SAH riboswitch with decarboxylated SAH; Chains: A,C 6ymm A 26 2.2 URS0001A24B50_1907202 32520325 1907202 ggunacaacggcuuccuggcgugacc <<<<<<..............>>>>>> ((((((..(........)..)))))) Crystal structure of the SAM-SAH riboswitch with SAM from space group P312; Chains: A 6ymm C 26 2.2 URS0001A24B50_1907202 32520325 1907202 ggunacaacggcuuccuggcgugacc <<<<<<..............>>>>>> ((((((..(........)..)))))) Crystal structure of the SAM-SAH riboswitch with SAM from space group P312; Chains: A 6ypu 2 894 2.9 RF00177,RF01959,RF01960 URS00007DA5A6_575584 32857965 0003735 0005840 575584 uaacugaagaguuugaucauggcucagauugaacgcuggcggcaggcuuaacacaugcaagucgagcgggggaagcggaccuagcggcggacgggugaguaaugcuuaggaaucugccuauuagugggggacaacaucucgaaagggaugcuaauaccgcauacguccuacgggagaaagcagggccuugcgcuaauagaugagccuaagucggauuagcuaguuggugggguaaaggccuaccaaggcgacgaucuguagcgggucugagaggaugauccgccacacugggacugagacacggcccagacuccuacgggaggcagcaguggggaauauuggacaauggggggaacccugauccagccaugccgcgugugugaagaaggccuuaugguuguaaagcacuuuaagcgaggaggaggcuacuuuaguuaauaccuagagauaguggacguuacucgcagaauaagcaccggcuaacucugugccagcagccgcgguaauacagagggugcgagcguuaaucggauuuacugggcguaaagcgugcguaggcggcuuauuaagucggaugugaaauccccgagcuuaacuugggaauugcauucgauacuggugagcuagaguaugggagaggaugguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgauggcgaaggcagccaucuggccuaauacugacgcugagguacgaaagcauggggagcaaacaggauuagauacccugguaguccaugccguaaacgaugucuacuagccguuggggccggcuuuaguggcgcagcuaacgcgauaaguagaccgccuggggaguacggucgcaagacuaaaacucaaaugaauugacgg ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<<........>>>.>>>>>......<<.......<<<<<<<..<<...<<<<<<<<<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<..>>>>>>>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>.....<<<<<......<<<<<<<<<<.......>>>>>>.>>>>........>>>>>.......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]...... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((...()...))).)))))......(((......(((.(((..((...(((((((((..(.....((((.(....).))))......)..).....(((....)))....(((((())))))))))))))..)).))).)))(((....(((..(((((((.........))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(..((((((((.(.......).)))).))))...)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))...((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))...)))...))))....((((((...((...((((.........))))...))))))))..........((((((..(((((((((((())))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].]...... Acinetobacter baumannii ribosome-amikacin complex - 30S subunit body; 16S ribosomal RNA 6ypu 4 146 2.9 RF00177,RF01959,RF01960 URS00007DA5A6_575584 32857965 0003735 0005840 575584 ccuuguacacaccgcccgucacaccaugggaguuuguugcaccagaaguagcuagccuaacugcaaagagggcgguuaccacgguguggccgaugacuggggugaagucguaacaagguagccguaggggaaccugcggcuggauc .............<..<<.<.<<<<.<<<..<<<.<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>.>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... ...........(.(..((.(.((((.(((..(((.(.((((((....(((((..((((..((....)).)))).)))))...)))))).).)))..))).))))..).))...)..)..(((((((((....)))))))))..... Acinetobacter baumannii ribosome-amikacin complex - 30S subunit body; 16S ribosomal RNA 6ys3 a 118 2.58 RF00001 URS0000049E57_469008 0003735 0005840 469008 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<..<..<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>.>...>>. ((....(((.....((((((((....(((.(((...(.....)...)))...)))...)))))).)).((.......((((((((...)))))))).......))...)))....)). Cryo-EM structure of the 50S ribosomal subunit at 2.58 Angstroms with modeled GBC SecM peptide; 5S rRNA 6ys3 b 2888 2.58 RF02540,RF02541 URS0000051AF4_469008 0003735 0005840 469008 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacagugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgauguggaaggccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugugaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcggcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccggccuugaaauaccacccuuuaauguuugauguucuaacguuggccccugaucgggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacuccuugagaguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuaac ..<...<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<.>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<...........>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<....<........<..<...<....<<.........>>....>..........<........>....>..>....>......>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<........>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<.<..<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>......>>.>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<<.<<.>>..>>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<..<<..............<<.....................................................>>.....>>..>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>.>.. ..(...((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...(((..((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))........((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((.))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((...(((((((((.....(((...(((.((((...(..................)...)))).)))..)).).....)))))).)))...))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((...(......{.(.......(...(...........)...)..........((........))......)....)...)..)).))...........]]].)...))))))))))...)))))))(((((((........)))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((..((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((((....((...((((....((((..(((..(((((((((((....{{{...))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((........)))...))))))...)))...))))(..).....))))...)).......).)))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((.))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((........(..........((....(.................................)..............)).)........)))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).((......)).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))).).. Cryo-EM structure of the 50S ribosomal subunit at 2.58 Angstroms with modeled GBC SecM peptide; 23S rRNA 6ys3 v 75 2.58 RF00005 URS00004CF48A_469008 0030533 0006412 469008 gcgggcaucguauaauggcuauuaccucagccuuccaagcugaugaugcggguucgauucccgcugcccgcucca ..<<.....<............>..<...............>.....<<<<<.......>>>>>..>>....... ................................................((((.......))))............ Cryo-EM structure of the 50S ribosomal subunit at 2.58 Angstroms with modeled GBC SecM peptide; glycine-tRNA glyT 6ys5 3 453 3.0 RF00177,RF01959,RF01960 URS00007DA5A6_575584 32857965 0003735 0005840 575584 gggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggccuugacauacuagaaacuuuccagagauggauuggugaaucuagauacaggugcugcauggcugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuuuuccuuacuugccagcauuucggaugggaacuuuaaggauacugccagugacaaacuggaggaaggcggggacgacgucaagucaucauggcccuuacggccagggcuacacacgugcuacaauggucgguacaaaggguugcuacacagcgaugugaugcuaaucucaaaaagccgaucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucgcggaucagaaugccgcggugaauacguucccggg ...<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<..<<<<....>>>>..>.....>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<<..<<<.....>>>>>.....>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>> ...((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(..((((....))))..).....))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.((((((....((..(((.....))))).....))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))) Acinetobacter baumannii ribosome-amikacin complex - 30S subunit head; 16S ribosomal RNA 6ys5 7 20 3.0 RF00005 URS00021ED9C2_575584 32857965 0030533 0006412 575584 gucgggcucauaacccgaag .<<<<<.......>>>>>.. .(((((.......))))).. Acinetobacter baumannii ribosome-amikacin complex - 30S subunit head; E-site tRNA 6ysi 1 2672 2.5 RF02540,RF02541 URS0000211949_575584 32857965 0003735 0005840 575584 gucaaguaauuaagugcaugugguggaugccuuggcagucagaggcgaugaaagacgugauagccugcgaaaagcuccggggaggcggcaaauauccuuugauccggagaugucugaaugggggaacccaccuacuuuaagguagguauugcaacaugaauacauaguguugcaaggcgaacgaggggaagugaaacaucucaguacccuuaggaaaagaaaucaauugagauucccucaguagcggcgagcgaacggggaucagcccauuaaguuauguguguuuuaguggaacgcucugggaagugcgaacguagagggugauauucccguacacgaaagggcacacauaaugaugacgaguagggcgaggcacgugaaaccuugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccugugaggggagugaaauagauccugaaaccgcaugcauacaagcagugggagcaccuuuguggugugacugcguaccuuuuguauaaugggucagcgacuuauauucaguagcgagguuaaccguauaggggagccguagagaaaucgagucuuaauagggcguuuaguugcuggguauagacccgaaaccaggcgaucuauccaugagcagguugaagguuggguaacacuaacuggaggaccgaacccacugucguugaaaagccaggggaugacuuguggauaggggugaaaggcuaaucaagccuggugauagcugguucuccccgaaagcuauuuagguagcgccucggacgaauaccauaggggguagagcacuguuucggcuaaccgaugcaaacuccgaauaccuaugaguacuauccgggagacagacugcgggugcuaacguccguagucaagaggaaaacaauccagaccgccagcuaaggccccaaaaucauaguuaagugggaaacgaugugggaaggcaagucggccugcgcggaagauguaacggggcuaaaacuaugugccgaagcugcggauguauacuuuguauacgugguaggggagcguucuguaagccgaugaagguguguugagaagcaugcuggagguaucagaagugcgaaugcugacgugaguaacgacaaaacgggugaaaaacccguucgccgaaagaccaaggguuccaguccaacguuaaucggggcugggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaaaugguuaauauuccauuacuucuguguaaugcgaugagaggacggagaaggcuaaaucagccuggcguugguuguccaggugaaaggauguaggcauguaucuuaggcaaauccgggguacucuaugcugagaucugaaagugguugaugccaugcuuccaggaaaagucucuaagcuucaguuacacaggaaucguacccgaaaccgacacagguggucaggucgaguagaccaaggcgcuugagagaacucugcugaaggaacuaggcaaaaugguaccguaacuucgggagaagguacgcuguuguuggugauugagcugacgacagccgcagaaaccaggccgcugcaacuguuuauuaaaaacauagcacucugcaaacacgaaaguggacguauagggugugaugccugcccggugcuggaagguuaauugaugggguuagcguaagcgaagcucuugaucgaagccccaguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcauaaugauggcggcgcugucuccagcagaggcucagugaaaucgaaaucgcugugaagaugcaguguacccgcggcuagacggaaagaccccgugaaccuuuacugcagcuugacacugaacugguucuaacucugucccgugauccgggacgaggaccgugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggaguacgaaggugcgcucagcguggucggaaaucacgcguagaguauaaaggcaaaagcgcgcuuaacugcgagacccacaagucgagcagguacgaaaguaggucuuagugauccggugguucuguauggaagggccaucgcucaacggauaaaagguacucuggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucucauccuggggcugaagcaggucccaaggguauggcuguucgccauuuaaagagguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucuaccgugggcgcuggaaauuugagaggaucugcuccuaguacgagaggaccagaguggacgaaccucugguguaccgguugugacgccagucgcaucgccggguagcuauguucggaagggauaaccgcugaaagcaucuaagcgggaagccuaccucaagauaagauuucccuaggacuuuauguccucuaaagagccguucgagacuaggacguugauagguuggauguggaagcauagugauaugugaagcugaccaauacuaauugcucgugaggcuugacu <<<<<<<......<<<<<<<<<<<.....<<.<<<<<<<<<<<<<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<.)))...]..>>.....>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<......<<<<<<<<<<<<<<.<<<...<<<.<......>.>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>...........<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>>.>>>..............<<....>>....>>.........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<.....>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<.<........>.>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<....<<<<<<<<<.....<<<...<<<.<<<<....>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<....>>..>>>>>.>>...........)))......>>>>>>.>>>...>>>>>>><<<<<<<<...>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<...[[[[...>>>>>>....<<<<...<<<<.<<<<<<..<<.....>>.>>>>>>....>>>>...>>>>.....>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<<<<<<<......>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<..<<....>>...>>>>>.>.....>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<.<<<<.<<......<<<<.<<<<<<..<<<<..<<<.<<<<<.<<<<..>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>...>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<.................>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<<<<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>...>>>>..>..>>>>>>>. (((((((......((((((((((.....(((..(((((((((((((......((((((....[[[.))).....((((((...((.]]]......))......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.....((((((((((((((.(((...(((.(......).)))[[(...).(((.....]])))...)))...))))))))))))))......)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((.....)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((.(.......<).))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).(((((((....(((((((((.....(((...(((.((((....)))).)))..)).).....)))))).)))...)))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...({((((((...........((..(((((..(((..)))..))))).))...........]]].....}))))))))))...)))))))(((((((.....)))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..(((((((((((....{{{...))))))....(((....((((.(((((((.((.....)))))))))....))))....))).....)))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((......))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..(((((((..(((.((......(((...(((((..(((((.(((.(((((.((((..))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(..((((.........))))....).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..)..)))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))..>.))..))).)))))))[...(((((((...((((..((((((......(....).....)))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.((((((..).)))))(....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))..).)))))))). Acinetobacter baumannii ribosome-tigecycline complex - 50S subunit; 23S ribosomal RNA 6ysi 5 115 2.5 RF00001 URS0000143D25_575584 32857965 0003735 0005840 575584 gcuggcgaccauagcaagagugaaccaccugaucccuucccgaacucagaagugaaaccucuuagcgcugaugguagugugggauuacccaugugagaguaagucaucgccagcu <<<<<<<<.....<<<<<<<.....<<<<<<<.............>>>>..>>>....>>>>>.>><<<.......<<<<<<<....>>>>>>>.......>>>..>>>>>>>>. ((((((((.....(((((((.....(((((((...(.....)...))))..)))....))))).))(((.......(((((((....))))))).......)))..)))))))). Acinetobacter baumannii ribosome-tigecycline complex - 50S subunit; 5S ribosomal RNA 6ysr A 2903 3.1 RF02540,RF02541 URS0000A76322_562 32796827 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccgggagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<................>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<..................................<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<........>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<<.<<....>>..>>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<..................<.<....<.........<..<<......>>..>......>..............>.>.........>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>.(<<...<<<<<<<...<<<<<<.......>>>>>>.....<<)..(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((.(((((((((.(((...(((((......)))))[[......(((.....]])))...)))...))))))))).)))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((................))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((.((..(((.....{.((.((.(....(.............).....).......(((......)))..)).))...)))..)).)).))...........]]].)...))))))))))...)))))))((((((..........))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((..((.((.....))))..))))..))))..[))))...))(...((((....))))....))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((..(.................(..((........((...(......)...)).....))............)........)..)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Structure of the P+9 stalled ribosome complex; 23S ribosomal RNA 6ysr B 120 3.1 RF00001 URS0000049E57_562 32796827 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Structure of the P+9 stalled ribosome complex; 5S ribosomal RNA 6ysr a 1539 3.1 RF00177,RF01959,RF01960 URS00000ABFE9_562 32796827 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<........>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..........>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<...........>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((((..........)))).)))))..)))))......(((......(((((((..((...(((((((...((.....((((((....))))))......)).......(((....)))....(((..(..........)..))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....(.((((...........)))).).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.(((((((.((......((((((.....))))))....)).)))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....))))))).............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Structure of the P+9 stalled ribosome complex; 16S ribosomal RNA 6ysr w 76 3.1 RF00005 URS00021ED99D_562 32796827 0030533 0006412 562 gcccgganagcucagucgguagagcaggggauugaanauccccgunuccucggnucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>><<<<<<<.....>>>>>>.>...<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((.........)))).....(((((..]....)))))))))))).... Structure of the P+9 stalled ribosome complex; P-site fMet-Phe-tRNA(Phe) 6ysr x 15 3.1 32796827 562 auguucaauauguuu ............... ............... Structure of the P+9 stalled ribosome complex; mRNA 6yss A 2903 2.6 RF02540,RF02541 URS0000A76322_562 32796827 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccgggagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu 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((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......((((.(((((.((.(((...(((((......)))))[[......(((.....]])))...)))...)).))))).))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((.(...........)..))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((.(......(.............).............(((......)))..).)))...)))..))))).))...........]]].)...))))))))))...)))))))((((((..........))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((.(..(.................(..((........(((..(......)..))).....))............)........)..).)))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Structure of the P+9 ArfB-ribosome complex in the post-hydrolysis state; 23S ribosomal RNA 6yss B 120 2.6 RF00001 URS0000049E57_562 32796827 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Structure of the P+9 ArfB-ribosome complex in the post-hydrolysis state; 5S ribosomal RNA 6yss a 1540 2.6 RF00177,RF01959,RF01960 URS00000ABFE9_562 32796827 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggaucaccuccu ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<..........>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<......>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>.............>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<..<.<<<<<<<........>>>>>>>>...>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((.(((..........)))..)))))..)))))......(((......(((((((..((...(((((((...((.....((((((....))))))......)).......(((....)))....((((.(..((....))).)))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....(.((((.(.......).)))).).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.(((((((.((......((((((.....))))))....)).)))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...((((((....))))))..............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..((.......))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Structure of the P+9 ArfB-ribosome complex in the post-hydrolysis state; 16S ribosomal RNA 6yss w 76 2.6 RF00005 URS00021ED99D_562 32796827 0030533 0006412 562 gcccgganagcucagucgguagagcaggggauugaanauccccgunuccucggnucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((.........)))).....(((((..]....)))))))))))).... Structure of the P+9 ArfB-ribosome complex in the post-hydrolysis state; P-site tRNAPhe 6yst A 2903 3.2 RF02540,RF02541 URS0000A76322_562 32796827 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccgggagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<.........>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<...................................<<<......>>>...>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<<.<<....>>..>>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<........................<.........<..............>......>.........................>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>.(<<...<<<<<<<...<<<<<<.......>>>>>>.....<<)..(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((.((((((.((.(((...(((.(......).)))[[......(((.....]])))...)))...)).)))))).)))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))..(((((((..((((((((((.....(((...(((.((((...((..(((.....)))...))...)))).)))..)).).....)))))).)))..)))))))).....(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(.(.....{.((..(..................................(((......)))..)..))...).)..))))).))...........]]].)...))))))))))...)))))))((((.((((....)))).))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..(((.....((((.((..((.((.....))))..)).)..)))...[.)))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....((....(((((..)]))))....))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..((.........((.((..((....))...)).)).........)))))))..)))))(.(((.........))).)........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.((..(((((.(((((((.(.(..(................(...(.........((...(......)...))......)............)........)..).).)))))))...(((.((((((.....)))))))))....)))))..))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....((.((((.((..]]]]..)))))).)).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Structure of the P+9 ArfB-ribosome complex with P/E hybrid tRNA in the post-hydrolysis state; 23S ribosomal RNA 6yst B 120 3.2 RF00001 URS0000049E57_562 32796827 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((.(.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...).)))))))). Structure of the P+9 ArfB-ribosome complex with P/E hybrid tRNA in the post-hydrolysis state; 5S ribosomal RNA 6yst a 1540 3.2 RF00177,RF01959,RF01960 URS00000ABFE9_562 32796827 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggaucaccuccu ........<<<<...[((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<...<<<<<<<..........>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<..........<<............>>...............<<<....>>>....<<<<..............>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>...>>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<.......<<<....>>>......>>>>..<..<<<<<......<.<<<<<............>.>>>>.>........>>>>>.....>.<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<....>>>>>>..............>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<.<<....>>...<<<<......>>>>..>>>>>>.....<<<..<<<<<<<...<....<.......>..>....>>>>>>>.....<<<<<.....>>>>>.........>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ ........((((....[[[..)))).(((..(((((..(((((((((....(((.(((..(.(..((.((..(((((((..........)))).)))))..))).)......(((.......((((((..((...(.(((((....(.....((((........))))......)........(((....)))....(((.(.............)))).))))).)..)).)))))).(((....(((..((((((((.......)))))))))))......)))..((((.(((....)))....))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..(((........(((....))).......)))..((.(((((...(....(.(((..(.......)..))).).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..))))).)))..........((([[...(.((((...(((.(((((((.(((((((.((......(((.((.....)).)))....)).)))))..)))))))))..(((((((((....(((((((....(((((((...((........))......)))))))....).......((....)).))))))...)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((.(((.....))).))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]]..(((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(....((((((...((.(((....))).))..............))))).).).((.((....((((((.(....((((((.((....))....(((......)))...)))))).....((...(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)....)).....).).)))...))..))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.(((...((....))..)))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Structure of the P+9 ArfB-ribosome complex with P/E hybrid tRNA in the post-hydrolysis state; 16S ribosomal RNA 6yst w 76 3.2 RF00005 URS00021ED99D_562 32796827 0030533 0006412 562 gcccgganagcucagucgguagagcaggggauugaanauccccgunuccucggnucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((.........)))).....(((((..]....)))))))))))).... Structure of the P+9 ArfB-ribosome complex with P/E hybrid tRNA in the post-hydrolysis state; P/E-site tRNAPhe 6ysu A 2903 3.7 RF02540,RF02541 URS0000A76322_562 32796827 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccgggagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((............<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...............<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<................>>...>>>>.>>>..>>.>.....>>>>>>>.>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<.<<.<.......................>........<<<......>>>..>>.>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<........>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<..<<....>>...>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<....................<..............<..............>....................>............>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.(.((......(((.(((((((((.(((...(((((......)))))[[......(((.....]])))...)))...))))))))).)))...)).)...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((.........<..))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((................))...)))).)))..)).).....))))))).))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((.((..(((.....{.((..(.(....(.............).....).......(((......)))..)..))...)))..)).)).))...........]]].)...))))))))))...)))))))((((.((........)).))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..(((.....((((((((.((.((.....)))).)))))..)))...[.)))...))(...((((....))))....))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((.(((.((.(..(.................(..((.........(..............)......))............)........)..).)).))).))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((.(...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....).)))))(.(((((.....)))))(....((..(((((.......)))))....((((((((........(((((....)))))........))))).))).....))..).))))))))). Structure of the P+0 ArfB-ribosome complex in the post-hydrolysis state; 23S ribosomal RNA 6ysu B 120 3.7 RF00001 URS0000049E57_562 32796827 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(.(((((...(.....)...))))..).)...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Structure of the P+0 ArfB-ribosome complex in the post-hydrolysis state; 5S ribosomal RNA 6ysu a 1540 3.7 RF00177,RF01959,RF01960 URS00000ABFE9_562 32796827 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggaucaccuccu ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<..........>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<...<<.....<<<<<......>>>>>......>>.......<<<....>>>....<<<<<............>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<.......<<<....>>>......>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<...<<<.....>>>.>..>.>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>............ ........((((..[.[[[..)))).(..(.(((((..(((((((((....(((.(((..(((..((.((..(((((((..........)))).)))))..)))))......(((......(((((((..((...(((((((...((.....((((((....))))))......)).......(((....))).....((................))..)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..(((.......((((....))))......)))..((.(((((...(....(.((((.(.......).)))).).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..))))))..)..........((([[...(.((((...(((.(((((((.(((((((.(.......((((((.....)))))).....).)))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...((((((....))))))..............))))).))).((.(((...((((((.(....((((((.((....))....(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(.((((......(((..((...(((....)))...))....)))......)))).)......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Structure of the P+0 ArfB-ribosome complex in the post-hydrolysis state; 16S ribosomal RNA 6ysu w 76 3.7 RF00005 URS00021ED99D_562 32796827 0030533 0006412 562 gcccgganagcucagucgguagagcaggggauugaanauccccgunuccucggnucgauuccgaguccgggcacca <<<<<....<<<<........>>>><<<<<<<.....>>>>>>.>...<<<<<.......>>>>>..>>>>>.... (((((....((((.....[..)))).((((.........)))).....(((((..]....)))))..))))).... Structure of the P+0 ArfB-ribosome complex in the post-hydrolysis state; P-site tRNAPhe 6yt9 2 894 2.7 RF00177,RF01959,RF01960 URS00007DA5A6_470 32857965 0003735 0005840 470 uaacugaagaguuugaucauggcucagauugaacgcuggcggcaggcuuaacacaugcaagucgagcgggggaagcggaccuagcggcggacgggugaguaaugcuuaggaaucugccuauuagugggggacaacaucucgaaagggaugcuaauaccgcauacguccuacgggagaaagcagggccuugcgcuaauagaugagccuaagucggauuagcuaguuggugggguaaaggccuaccaaggcgacgaucuguagcgggucugagaggaugauccgccacacugggacugagacacggcccagacuccuacgggaggcagcaguggggaauauuggacaauggggggaacccugauccagccaugccgcgugugugaagaaggccuuaugguuguaaagcacuuuaagcgaggaggaggcuacuuuaguuaauaccuagagauaguggacguuacucgcagaauaagcaccggcuaacucugugccagcagccgcgguaauacagagggugcgagcguuaaucggauuuacugggcguaaagcgugcguaggcggcuuauuaagucggaugugaaauccccgagcuuaacuugggaauugcauucgauacuggugagcuagaguaugggagaggaugguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgauggcgaaggcagccaucuggccuaauacugacgcugagguacgaaagcauggggagcaaacaggauuagauacccugguaguccaugccguaaacgaugucuacuagccguuggggccggcuuuaguggcgcagcuaacgcgauaaguagaccgccuggggaguacggucgcaagacuaaaacucaaaugaauugacgg ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<<........>>>.>>>>>......<<.......<<<<<<<..<<...<<<<<<<<<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<..>>>>>>>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<<<<<<<<<<.......>>>>>>.>>>>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]...... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((...()...))).)))))......(((......(((((((..((...(((((((((..(.....((((((....))))))......)..).....(((....)))....(((((())))))))))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(..((((((((((.......)))))).))))...)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))...((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))...)))...))))....((((((...((...((((.........))))...))))))))..........((((((..(((((((((((())))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].]...... Acinetobacter baumannii ribosome-tigecycline complex - 30S subunit body; 16S ribosomal RNA 6yt9 4 146 2.7 RF00177,RF01959,RF01960 URS00007DA5A6_470 32857965 0003735 0005840 470 ccuuguacacaccgcccgucacaccaugggaguuuguugcaccagaaguagcuagccuaacugcaaagagggcgguuaccacgguguggccgaugacuggggugaagucguaacaagguagccguaggggaaccugcggcuggauc .............<..<<.<.<<<<.<<<..<<<.<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>.>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... ...........(.(..((.(.((((.(((..(((.((((((((....(((((..((((..((....)).)))).)))))...)))))))).)))..))).))))..).))...)..)..(((((((((....)))))))))..... Acinetobacter baumannii ribosome-tigecycline complex - 30S subunit body; 16S ribosomal RNA 6ytf 3 453 3.0 RF00177,RF01959,RF01960 URS00007DA5A6_575584 32857965 0003735 0005840 575584 gggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggccuugacauacuagaaacuuuccagagauggauuggugaaucuagauacaggugcugcauggcugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuuuuccuuacuugccagcauuucggaugggaacuuuaaggauacugccagugacaaacuggaggaaggcggggacgacgucaagucaucauggcccuuacggccagggcuacacacgugcuacaauggucgguacaaaggguugcuacacagcgaugugaugcuaaucucaaaaagccgaucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucgcggaucagaaugccgcggugaauacguucccggg ...<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<...<..<<<<....>>>>..>......>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<<..<<<.....>>>>>.....>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>> ...((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((....(..((((....))))..).......))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.((((((....((..(((.....))))).....))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))) Acinetobacter baumannii ribosome-tigecycline complex - 30S subunit head; 16S ribosomal RNA 6ytf 7 20 3.0 RF00005 URS00001BBAFC_575584 32857965 0030533 0006412 575584 gucgggcucauaacccgaag .<<<<<.......>>>>>.. .(((((.......))))).. Acinetobacter baumannii ribosome-tigecycline complex - 30S subunit head; E-site tRNA 6ywe A 2837 2.99 RF02541,RF02540 URS00021ED918_5141 33056988 0003735 0005840 5141 guaauggauauaaagcuuauguuuauauauauauauaaguauauaaagagacuacuaccaauagcuacacuauguauuaaggagaguauaacuuaauuuauguuuaugauagagguuaucaacauaugaacucuuagagaaauuacuuaauaaacgaagugaauugaaauaucuuauuaacuucaggaaaagaaaucaaacgagauucuaugauuagugugaacgaaaauagagcagccuauuaaaauaaguaaaauggcuuuaaagcuguuugaauauuguggggaaccuuccucaaaggcuaaauauaauacaugaguuacagagaaaaguaccgugagggaaagcuuugaaauaguaguuuuauaagcagcucaagcaauaagaaagcgagagcguaccuuuugcauaaugggucaccaaguuaauuuuagaugcgagcgaauuagaugugcauaguuaaaccgaucauuaaaauaaugaauagugucuaaaguuagacccgaagccuggugaucuuacuauagucaggacuauaaagguccgaacggguuaucguugcaaagauauccgaagaacuaugguaagcgagugaaagacaacacugacuaggauagcugguuuucugcgaaaccuauaauaguaggcaauuuaaguaacaucuuaguagguacagaacuuaaucucagacaagauguagauuuucauaccuagguaugaaaugcauuuuuuuuuguauacaucgggggaucgugaagauuuuaucggugaguauguagacucggaaugacaaagaugaaucuugaauaaucagacauagaaugauaagguuguaugucaaaagggaaacagcccagaacaagaguuaagguuccaaaauuauuauuaagugaaauaaagaaaguuuuuauauaagucgacaagaagaugggcuuggaagcagccauaauuuaaagaucucguaacagagcacuuguuaaaucuuaaaagcaucgaaaauuuaacggaucuaaauaauauaccgaaaccuuguccauauguaacauuaguaauaauauuaauguuauuugaugggguagcagaacguugagugaaucuuagauuuuuuuuuuauaacuaaauauagaugauaacucaagugagaauggugacaugaguaacaaaaaagaguuuaagguaccuaaaagguaucuuagagucucgccuaaagcuuauggcuacgucaaguaacggccucuaaguuuauaaucugaagauuaugacgaugagaaaacuuugguaccaacauuuaaaagugaaaauugugcaggaaggauaaaccguaccuagaaucugaaacaaguaagcuaguagagaauacgaaggcgugaaugagauaacaaucauaaaggaacucggcaaacuaacuaccguaacuuagggauaaggagagcucauuagucucgaacgaguaaaaaggaagaagcauggaauauuguuguacgacuguuuaauuaaaacaaagcacuuugcaaaaagacgauaagucuaaguauugagugugauuucugcccgaugccggcugguuaacgaauuuucuaaauugaaaaaaaauuugguuucagaggaacccccgguuaauggcggccuuagcgugaggguccuaagguagcgaaaugccuuggccguuaaaugcggucuugcaugaaugauguaacgauacaacagcugucucuaugauugacucagugaaauuggaauaacugugcagauacaguuuaccucuaguuagacgagaagacccuaugcagcuuuacuguuacuaauuauugaauacgauucugaaaauuuccaguguaaaagguaaucgauaagauauaauugaaacaccuuuauuuuucuaucguauuauuaaaccuuaaauuaaggaacaauuguuagaagacaguuuaugcggggcacaggccccauaaagaguaaaugggugugucuaaaauguuugcaauuuuuuauaguauauaucaaaucaucuuuaugcuauucauagaccuuggguacaguauaaaaauuauauauguauuaauuuacauauauuuuuucuaagaaauuagguaagauuuuguuuauagagaaauuagauguaaaaaaaaaaucuuaugagggcggauccgcuucuaauauuuuuuuguaguuauuauuauaauaauaaucauguuuauuacuuaaaaagcuuaauggcuuaaucuugccuuacuguuugauuaacaacaaaucuuacagucgcguaagcggggcauaggaucacaagauacaaaaaggaaagaucuuggauuuuuggaaaagcuacgcuagggauaacaggcuaauuugcgcaagaguguacaaaaugagugcgcgguuuggcaccucggcuugacuaauccucauggaugcagaaacuauguaggguacgacuguucgucgauuaaaaaguuacaugagcuggguuaaauacgucgugagacaguaugguuucuaucuucuagagggaauuagaauauaauaaggauuaaccuuuguacgaaaggaacaugggguacuauuguuaacaguuuuauuaaccucugguuuaccuguuguuuaugugccuuagggauguuaccgucacuugaguaaauacaauagcauaagcauggcaggaaagcuaaguuagucaaaaauaagugcugaaagcauauaggcacgaaauuuaccuuaagauauuucuuaaauauacguaagaaaauauuacguuaauaggcuuaguuuguaauaaucuagagauuuuaaggaacuaaguacuaauuuuauaaaaaacugaaugauuaauauaucuuaca 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((((..((((((.......(((((((((..))))...(((..(....((((((((((...[.(((....((((((((((.(((((..{..[.)...[.((((((...........}.]].))))))....))))..((....))..........((((((.....(......)......))))).).........((....))...(((((.....((....))....)))))...(((..............(((((((......)))))))........(((((..{{{{)))))..)))......))))))))).)...............((....))....)).).....)))))))))).....(.((((..((.........))..)))).{.(.(........).).((((((....(((((((((((((..((...........))...(......)..((((.......))))...)))))))))))))..((.(...((((((.....((((((((((.((((......){)))...(((..((((.......A)))).)))..).))))))))).(...((.....))....)..))))))....).))..((((((....(((((....)))))...(((((([.(((((((.((.....(((...(..((((((.(((((.((.....((((((........))))))..)).).....))))......((..(((.(.....).)))...)).)))).))..)..)).).....)).)))))).])))))))......((((((.(((......))).))))))....(((......)))...(((((.((...((([[[...(.((((((.....((......((..(((((((.......<((((((......(((.........)))..........(..(((......)))).))))))......))))))).))...........]]]))...))))))))))...)))))))(((((.((((((((((((....)))))))))))).).))))....))))))(.((((((..(((.....(.]((..((...))..))..).....))).))))))..).....))))))(......((.....(((.(((((((((((.....))))))))))).)))((((....((((..((.(......[[...(((.(((.(.(((.((((((....)))))))))..))))....]](........(((.((..[[[[[..)).))).(..).......).))).)))......((......)).))))..((.......))...))))....((((....((((((((.((..(....(........((.((....(.[..).....))))..(((.((..(((((..)))).<).)).).)).(...).......(((((((((.}.((.........))...((((((........(((.....)))........)))))).]..((.(((..(((((((..((....(.......(((((((.......))))))).......)....)))))))..)))))(((((........)))))........((..........((((((.....))))))..)..)....)).....)).))))))).)..))).)))))))).)))))).....)).[..(((((.....}].)))))..(((((((..(((.((.....(((((.((((((..(((((..(((((.((..((((((((...(((((.(......[..(((((..(((.....)))..........].)))))).))))).))))))))......((((.....))))....)).)))))...)))))...((.......)).((((((...........)))).))..((.....(.......(((..((((...))))..))).)......(...((((((.......))))))...........).(((((((((......)))))))))................(((((((..((.((((.........)))).((((..((..(.(.(((.((.((.((..)).))))))).)...).))...(((((((((())))))))))........))))....)).((...[[[))....)))))))...((((..(((......<..)))..)))).(((....))).))]]].......((((((.(...}}}}...))))))).......>....))))..)))))))......((((.(...(((((...((.......))...)))))....)))).)..((((.(((((...((((((((.........)))))..)))..((((.....)))).......))))..)...))).).....(((((((....))).))))..a.))..))).)))))))....)((((((...(((((...((((......(....)......))......(((((..))))))).((((((...((((...((((((((((((((.(((()))).(.((((...]]]]]..)))).....)>.)))))))))..)))))...)))).))))))..(((....(((((....>......)))))....))).)))))...))).)))....(((.(((((.......)))))....((((((((((((.....((((....))))....))).)))))).))).....)))....)))))))).....)))))))))). The structure of the mitoribosome from Neurospora crassa in the P/E tRNA bound state; 23S rRNA 6ywe bb 74 2.99 RF00005 URS00021ED8EC_5141 33056988 0030533 0006412 5141 ggcugaguagcucaaugguagagcauaccguucauaacgguauugucuguguucgauccacagcucagccacca <<<<<<<..<<<<.......>>>>.<<<<<<.....>>>>>>....<<<<<.......>>>>>>>>>>>>.... ..(((((..((((.......))))((((((.......))))))...(((((.......))))))))))...... The structure of the mitoribosome from Neurospora crassa in the P/E tRNA bound state; tRNA P/E state 6ywe aa 1435 2.99 RF00177,RF01959,RF01960 URS00021ED984_5141 33056988 0003735 0005840 5141 auagaugaguuuggugauggcucugauugaacacuguccaaauacuugacacaugcuaaucgaacguuuaauuuuggcucuuaauuaaaagugguguacaggugaguauaauauuuuuucgcuuaacuuaaagugaaggcaaauccuucauauugcaaaaggauaucuauauccgcuuuaagaggaugagaaaaguuucagagauagguaguuguuaaggucauggcuuaacaagccaauaauucucuuagucgaagcugaaaaggcugaucgaccacauugggaaugaaaaaaucccaaggcaaauagguacagcagugaggaaucuuggucaaugggcccacgccugaacugguaacuuggaggaaugagacgucgauuuaucgaguaaaauucuguauacauauugauaaugacaauauguacauuugucuugacuaauuacgugccagcagucgcggcaauacguaagagacuaguguuaaucaucauaaauagguuuaaaggguacucagacggaaaaauucgcccaaauauaggggacaauuuuucuagaguuuuauguaagaaggucguacucuagaguggagagauaaaauucugugauaccuaggggacggguaaaggcgaaggcaaucuuuuauguaaaaacugacgucgaaggacgaaggcaaagggaacaaaaaggauuagauaccccaguagucuuugcagacaauuaugaaugccauagguuagauuuuuaauuuagucuauaaaugaaaguguaagcauuucaccucaagaguaaggcggcaacgcaggaacugaaaucacuagaccguuucugacaccagcaaugaaguauguuauuuaauucggugacccacgaaaaaccuuaccacaauuugaauauuaauuauuaauacaaguguugcacggcugucuucaguugauguugcgaaacugugguucguuccauggaauuaacguaaacccuugcuuuauuuguaaauauuauaaagcaguucaccuuuauauaggaaaugauaaaagggaucaagacaagucaucauggccuaaauauugugggcuauagacgugccacauuuuccuaaacaaagagaugcaaaaaugugaauuuuagcuaaucucaaaaaauaggauaaaaauauacaaggauuguagucugaaauucgacugcaugaauaagaaauugcuaguaaucgugaaucaccaugacacggugaauauucccucggauugguacuaaccacucgucacaugcugaaaggagugcgugcaauaaguuugcuuuucuguuauaaguaaguagacauauagguuuagauguuauaauaggauccuucguaugcgcggcucugauuaguguuaagucgaaauacgguucguguaguggaaguugcacgggacuuaucaauguugaacaauacga ......((((..<<<<<<.))))<<<<<.<<<<<..<<<<<.<<.....<<<.<<<..<<<..<<.<<<<<<<..<<.>>..>>>>>>>.>>>>>......<<.........<<<<<<<..<<...<<<<<<<<<<<<<.....>>>>>...........<<<<<<..>>>>>>>>>>>>>>.>>...(>>>>>>>...<<<<<..<<<..<<<<<<<<....)..>>>>>>>>>>>......>>>>>..<<<<.<<<<.....>>>>...>>>>.>>.<<<<<...........>>>>>.<<......>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>..>>>>>.<<<<......<<<<....>>>>.....>>>>....<<<<<<<<<.......>>>>>>>>>.....<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>>.........<<<((.....<<..<..<<<.<<<<<<<<.<<<<.......>>>..>>>>>>>>>...<<<<<......<<<<<<<.<..<<<<<<.<<<..<<<......>>>.....>>>>>>>>>..>........<<....>>.>>>>>>>......>>>>>...>>>...>.>>....<<<<<<...<<.....<<.........>>.....>>>>>>>>..........<<<<<<.<<<<<<<<<<<<...>>>>>>>>>>>>..<<..))>>....>>>>>>.>>>.<<........<<<....>>>......>>..>>>>>><<<<<...<<<<<....<<<<<<...<<<<<<<<<......<<........>>..........<<<<<<<.....<<<<<<<.>>>>>>>..<<.<<...<.<<<<<<<....<<<<<<<<<....>>>.<<<<......>>>>...>>>>>>.....<<<<<<<<<<<<...........>>>>>>>>..<<.<<<......>>>....>>....>>>>.....>>>.>>>...>.>.>>>>....>>>>>>>...>>.>>>>>>>.......<<<<<......<<<..<<..<<<<....>>>>..>>....>>>......>>>>>............<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<...........>>>>>>..........>>>>>..>>>.>>....<.<<<.<..<<<<<<<..<<<<<.<<<<<<....<.......<<<<<<<<<<<.....<<<<<......>>>>>....>>>>>>>>>>>.....>...>>>>>>>>>>>..>>>>>>>...>.>>>..>.....<<<<<<<<<....>>>>>>>>>......................... ......[[[[..(((((..]]]].((((.(((((..(((((.(((....(((.(((..(((..((.(((((((..(...)..))))))).)))))......(((......(.((((((((.((...(((((((((((((.....)))))...........((((((..)))))))))))))).))..)[))))))))..(((((..(((..((((((((....]..)))))))))))......)))))..((((.((((.....))))...))))))).(((((...........))))).((......))...)))))).).....(.(((...(((((....)))).))))).))..))))).((((......(((((..))))).....))))....(((((((((.......))))))))).....((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((.....(((.((((((((.((((.......)))..)))))))))..((((((.......((((((((..((((((.((...((........))......))))))))..)).......((....)).)))))).......)))))..)))).....))....((((((...((.....((.........)).....))))))))......{...((((((.((((((((((((...))))))))))))..((..]]))....)))))))))).((........(((....)))......))...)))))(((((...(((((.(...(((((...(((((((((......((........))..........(((((((..(..(((((((.)))))))).((.(((....(((((((....(((((((((....))).((((......))))...)))))).....(((.((((((((...........))))))))..((.(((......)))....)).....))).....))).)))...)..)))))....)))))))...)).)))))))..(.....((((......(((..((...(((....)))...))....)))......)))).............(....(((((((........)))))))....)..)..))))).....((((((...........))))))......)...)))))..))).))..(.(..((.(..(((((((..(((((.((((((....(...(...(((((((((((.....(((((......)))))....)))))))))))..)..)...)))))))))))..)))))))...).))...)..)..(((((((((....)))))))))}......(...)............. The structure of the mitoribosome from Neurospora crassa in the P/E tRNA bound state; 16S rRNA 6ywe ee 11 2.99 33056988 5141 aauauuuaugu ........... ........... The structure of the mitoribosome from Neurospora crassa in the P/E tRNA bound state; mRNA 6ywx A 2838 3.1 RF02541,RF02540 URS00021ED918_367110 33056988 0003735 0005840 367110 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((((..((((((.......(((((((((..))))...(((..(....((((((((((...[.(((....((((((((((.(((((..{..[.)...[.((((((...........}.]].))))))....))))..((....))..........((((((.....(......)......))))).).........((....))...(((((.....((....))....)))))...(((..............((((.((......)).))))........(((((..{{{{)))))..)))......))))))))).)...............((....))....)).).....)))))))))).....(.((((..((.........))..)))).{.(.(........).).((((((..(.(((((((((((((..((...........))...(......)..((((.......))))...)))))))))))))..((.(...((((((.....((((((((((.((((......){)))...(((..((((.......A)))).)))..).))))))))).(...((.....))....)..))))))....).))).((((((....(((((....)))))...(((((([.(((((((.((.....(((...(..((((((.((((((((..(..((((((((.().))))))))).)))).....))))......((..(.(((.....))).)...)).)))).))..)..)).).....)).)))))).])))))))......((((((.(((......))).))))))....(((......)))...(((((.((...((([[[...(.((((((.....((......((..(((((((.......<((((((......(((.........)))..........(..(((......)))).))))))......))))))).))...........]]]))...))))))))))...)))))))(((((.((((((((((((....)))))))))))).).))))....))))))(.((((((..(((.....(.]((..((...))..))..).....))).))))))..).....))))))(......((.....(((.(((((((((((.....))))))))))).)))((((....((((..((.(......[[...(((.(((.(.(((.((((((....)))))))))..))))....]](........(((.((..[[[[[..)).))).(..).......).))).)))......((......)).))))..((.......))...))))....((((....((((((((.((..(....(........((.((....(.[..).....))))..(((.((..(((((..)))).<).)).).)).(...).......(((((((((.}.((.........))...((((((........(((.....)))........)))))).]..((.(((..(((((((..((....(.......(((((((.......))))))).......)....)))))))..)))))(((((........)))))........((..........((((((.....))))))..)..)....)).....)).))))))).)..))).)))))))).)))))).....)).[..(((((.....}].)))))..(((((((..(((.((......((((.((((((..(((((..(((((.((..((((((((...(((((.(......[..(((((..(((.....)))..........].)))))).))))).))))))))......((((.....))))....)).)))))...)))))...((.......)).((((((...........)))).))..((.....(.......(((..((((...))))..))).)......(...((((((.......))))))...........)...(..(.(........).)..)..................(((((((..((.((((.........)))).((((..(((((((.(((.((.((.((..)).))))))).))).))))...(((((((((())))))))))........))))....)).((...[[[))....)))))))...((((..(((......<..)))..)))).(((....))).))]]].......((((((.(...}}}}...))))))).......>....))))..)))))).......((((.(...(((((...((.......))...)))))....)))).)...((((.(((((...((((((((.........)))))..)))..((((.....)))).......))))..)...))).).....(((((((....))).))))..a.))..))).)))))))....)((((((...(((((...((((......(....)......))......(((((..))))))).((((((...((((...((((((((((((((.(((()))).(.((((...]]]]]..)))).....)>.)))))))))..)))))...)))).))))))..(((....(((((....>......)))))....))).)))))...))).)))....(((.(((((.......)))))....((((((((((((.....((((....))))....))).)))))).))).....)))....)))))))).....)))))))))). The structure of the mitoribosome from Neurospora crassa with tRNA bound to the E-site; 23S rRNA 6ywx aa 1435 3.1 RF00177,RF01959,RF01960 URS00021ED984_367110 33056988 0003735 0005840 367110 auagaugaguuuggugauggcucugauugaacacuguccaaauacuugacacaugcuaaucgaacguuuaauuuuggcucuuaauuaaaagugguguacaggugaguauaauauuuuuucgcuuaacuuaaagugaaggcaaauccuucauauugcaaaaggauaucuauauccgcuuuaagaggaugagaaaaguuucagagauagguaguuguuaaggucauggcuuaacaagccaauaauucucuuagucgaagcugaaaaggcugaucgaccacauugggaaugaaaaaaucccaaggcaaauagguacagcagugaggaaucuuggucaaugggcccacgccugaacugguaacuuggaggaaugagacgucgauuuaucgaguaaaauucuguauacauauugauaaugacaauauguacauuugucuugacuaauuacgugccagcagucgcggcaauacguaagagacuaguguuaaucaucauaaauagguuuaaaggguacucagacggaaaaauucgcccaaauauaggggacaauuuuucuagaguuuuauguaagaaggucguacucuagaguggagagauaaaauucugugauaccuaggggacggguaaaggcgaaggcaaucuuuuauguaaaaacugacgucgaaggacgaaggcaaagggaacaaaaaggauuagauaccccaguagucuuugcagacaauuaugaaugccauagguuagauuuuuaauuuagucuauaaaugaaaguguaagcauuucaccucaagaguaaggcggcaacgcaggaacugaaaucacuagaccguuucugacaccagcaaugaaguauguuauuuaauucggugacccacgaaaaaccuuaccacaauuugaauauuaauuauuaauacaaguguugcacggcugucuucaguugauguugcgaaacugugguucguuccauggaauuaacguaaacccuugcuuuauuuguaaauauuauaaagcaguucaccuuuauauaggaaaugauaaaagggaucaagacaagucaucauggccuaaauauugugggcuauagacgugccacauuuuccuaaacaaagagaugcaaaaaugugaauuuuagcuaaucucaaaaaauaggauaaaaauauacaaggauuguagucugaaauucgacugcaugaauaagaaauugcuaguaaucgugaaucaccaugacacggugaauauucccucggauugguacuaaccacucgucacaugcugaaaggagugcgugcaauaaguuugcuuuucuguuauaaguaaguagacauauagguuuagauguuauaauaggauccuucguaugcgcggcucugauuaguguuaagucgaaauacgguucguguaguggaaguugcacgggacuuaucaauguugaacaauacga ......((((..<<<<<<.))))<<<<<.<<<<<..<<<<<.<<.....<<<.<<<..<<<..<<.<<<<<<<..<<.>>..>>>>>>>.>>>>>......<<.........<<<<<<<..<<...<<<<<<<<<<<<<.....>>>>>...........<<<<<<..>>>>>>>>>>>>>>.>>...(>>>>>>>...<<<<<..<<<..<<<<<<<<....)..>>>>>>>>>>>......>>>>>..<<<<.<<<<.....>>>>...>>>>.>>.<<<<<...........>>>>>.<<......>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>..>>>>>.<<<<......<<<<....>>>>.....>>>>....<<<<<<<<<.......>>>>>>>>>.....<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>>.........<<<((.....<<..<..<<<.<<<<<<<<.<<<<.......>>>..>>>>>>>>>...<<<<<......<<<<<<<.<..<<<<<<.<<<..<<<......>>>.....>>>>>>>>>..>........<<....>>.>>>>>>>......>>>>>...>>>...>.>>....<<<<<<...<<.....<<.........>>.....>>>>>>>>..........<<<<<<.<<<<<<<<<<<<...>>>>>>>>>>>>..<<..))>>....>>>>>>.>>>.<<........<<<....>>>......>>..>>>>>><<<<<...<<<<<....<<<<<<...<<<<<<<<<......<<........>>..........<<<<<<<.....<<<<<<<.>>>>>>>..<<.<<...<.<<<<<<<....<<<<<<<<<....>>>.<<<<......>>>>...>>>>>>.....<<<<<<<<<<<.............>>>>>>>..<<.<<<......>>>....>>....>>>>.....>>>.>>>...>.>.>>>>....>>>>>>>...>>.>>>>>>>.......<<<<<......<<<..<<..<<<<....>>>>..>>....>>>......>>>>>............<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<...........>>>>>>..........>>>>>..>>>.>>....<.<<<.<..<<<<<<<..<<<<<.<<<<<<....<.......<<<<<<<<<<<.....<<<<<......>>>>>....>>>>>>>>>>>.....>...>>>>>>>>>>>..>>>>>>>...>.>>>..>.....<<<<<<<<<....>>>>>>>>>......................... ......[[[[..(((((..]]]].((((.(((((..(((((.(((....(((.(((..(((..((.(((((((..(...)..))))))).)))))......(((......(.((((((((.((...(((((((((((((.....)))))...........((((((..)))))))))))))).))..)[))))))))..(((((..(((..((((((((....]..)))))))))))......)))))..((((.((((.....))))...))))))).((((((.........)))))).((......))...)))))).).....(.(((...(((((....)))).))))).))..))))).((((......((((....)))).....))))....(((((((((.......))))))))).....((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((.....(((.((((((((.((((.......)))..)))))))))..((((((.......((((((((..((((((.((...((........))......))))))))..)).......((....)).)))))).......)))))..)))).....))....((((((...((.....((.........)).....))))))))......{...((((((.((((((((((((...))))))))))))..((..]]))....)))))))))).((........(((....)))......))...)))))(((((...(((((.(...(((((...(((((((((......((........))..........(((((((..(..(((((((.)))))))).((.(((....(((((((....(((((((((....))).((((......))))...)))))).....(((.((((((((...........))))))))..((.(((......)))....)).....))).....))).)))...)..)))))....)))))))...)).)))))))..(....(((((......(((..((...(((....)))...))....)))......)))))............(....(((((((........)))))))....)..)..))))).....((((((...........))))))......)...)))))..))).))..(.(..((.(..(((((((..(((((.((((((....(...(...(((((((((((.....(((((......)))))....)))))))))))..)..)...)))))))))))..)))))))...).))...)..)..(((((((((....)))))))))}......(...)............. The structure of the mitoribosome from Neurospora crassa with tRNA bound to the E-site; 16S rRNA 6ywx bb 61 3.1 RF00005 URS00021ED926_367110 33056988 0030533 367110 ggcugaguagcucaaaguagagcauaguaaugucuguguucgauccacagcucagccacca <<<<<<<..<<<<......>>>><<<.>>.>..<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[..)))).((.))....(((((..]....)))))))))))).... The structure of the mitoribosome from Neurospora crassa with tRNA bound to the E-site; tRNA E-site 6ywy A 2843 3.05 RF02541,RF02540 URS00021ED918_5141 33056988 0003735 0005840 5141 guaauggauauaaagcuuauguuuauauauauauauaaguauauaaagagacuacuaccaauagcuacacuauguauuaaggagaguauaacuuaauuuauguuuaugauagagguuaucaacauaugaacucuuagagaaauuacuuaauaaacgaagugaauugaaauaucuuauuaacuucaggaaaagaaaucaaacgagauucuaugauuagugugaacgaaaauagagcagccuauuaaaauaaguaaaauggcuuuaaagcuguuugaauauuguggggaaccuuccucaaaggcuaaauauaauacaugaguuacagagaaaaguaccgugagggaaagcuuugaaauaguaguuuuauaagcagcucaagcaauaagaaagcgagagcguaccuuuugcauaaugggucaccaaguuaauuuuagaugcgagcgaauuagaugugcauaguuaaaccgaucauuaaaauaaugaauagugucuaaaguuagacccgaagccuggugaucuuacuauagucaggacuauaaagguccgaacggguuaucguugcaaagauauccgaagaacuaugguaagcgagugaaagacaacacugacuaggauagcugguuuucugcgaaaccuauaauaguaggcaauuuaaguaacaucuuaguagguacagaacuuaaucucagacaagauguagauuuucauaccuagguaugaaaugcauuuuuuuuuguauacaucgggggaucgugaagauuuuaucggugaguauguagacucggaaugacaaagaugaaucuugaauaaucagacauagaaugauaagguuguaugucaaaagggaaacagcccagaacaagaguuaagguuccaaaauuauuauuaagugaaauaaagaaaguuuuuauauaagucgacaagaagaugggcuuggaagcagccauaauuuaaagaucucguaacagagcacuuguuaaaucuuaaaagcaucgaaaauuuaacggaucuaaauaauauaccgaaaccuuguccauauguaacauuaguaauaauauuaauguuauuugaugggguagcagaacguugagugaaucuuagauuuuuuuuuuauaacuaaauauagaugauaacucaagugagaauggugacaugaguaacaaaaaagaguuuaagguaccuaaaagguaucuuagagucucgccuaaagcuuauggcuacgucaaguaacggccucuaaguuuauaaucugaagauuaugacgaugagaaaacuuugguaccaacauuuaaaagugaaaauugugcaggaaggauaaaccguaccuagaaucugaaacaaguaagcuaguagagaauacgaaggcgugaaugagauaacaaucauaaaggaacucggcaaacuaacuaccguaacuuagggauaaggagagcucauuagucucgaacgaguaaaaaggaagaagcauggaauauuguuguacgacuguuuaauuaaaacaaagcacuuugcaaaaagacgauaagucuaaguauugagugugauuucugcccgaugccggcugguuaacgaauuuucuaaauugaaaaaaaauuugguuucagaggaacccccgguuaauggcggccuuagcgugaggguccuaagguagcgaaaugccuuggccguuaaaugcggucuugcaugaaugauguaacgauacaacagcugucucuaugauugacucagugaaauuggaauaacugugcagauacaguuuaccucuaguuagacgagaagacccuaugcagcuuuacuguuacuaauuauugaauacgauucugaaaauuuccaguguaaaagguaaucgauaagauauaauugaaacaccuuuauuuuucuaucguauuauuaaaccuuaaauuaaggaacaauuguuagaagacaguuuaugcggggcacaggccccauaaagaguaaaugggugugucuaaaauguuugcaauuuuuuauaguauauaucaaaucaucuuuaugcuauucauagaccuuggguacaguauaaaaauuauauauguauuaauuuacauauauuuuuucuaagaaauuagguaagauuuuguuuauagagaaauuagauguaaaaaaaaaaucuuaugagggcggauccgcuucuaauauuuuuuuguaguuauuauuauaauaauaaucauguuuauuacuuaaaaagcuuaauggcuuaaucuugccuuacuguuugauuaacaacaaaucuuacagucgcguaagcggggcauaggaucacaagauacaaaaaggaaagaucuuggauuuuuggaaaagcuacgcuagggauaacaggcuaauuugcgcaagaguguacaaaaugagugcgcgguuuggcaccucgaugucggcuugacuaauccucauggaugcagaaacuauguaggguacgacuguucgucgauuaaaaaguuacaugagcuggguuaaauacgucgugagacaguaugguuucuaucuucuagagggaauuagaauauaauaaggauuaaccuuuguacgaaaggaacaugggguacuauuguuaacaguuuuauuaaccucugguuuaccuguuguuuaugugccuuagggauguuaccgucacuugaguaaauacaauagcauaagcauggcaggaaagcuaaguuagucaaaaauaagugcugaaagcauauaggcacgaaauuuaccuuaagauauuucuuaaauauacguaagaaaauauuacguuaauaggcuuaguuuguaauaaucuagagauuuuaaggaacuaaguacuaauuuuauaaaaaacugaaugauuaauauaucuuaca <<<<..<<<<<<.......<<<<<<<<<..>>>>...<<<.......<<<<<<<<<<......((.....<<<<<<<<<.<<<<<<.....>>.....<<<<<<................>>>>>>....>>>>..<<....>>..........<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<....>>....>>>>>>..((...............<<<<<<<<....>>>>>>>>........<<<<<..<<<<>>>>>...))......>>>>>>>>>.................<<....>>....)).......>>>>>>>>>>.......<<<<..<<.........>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<...........>>...<......>..<<<<<.....>>>>>...>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<<<....>>.>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>.....<<.....>>.......>>>>>>.>..>.>>..<<<<<<....<<<<<....>>>>>..<<<<<<<...<<<<<<.<<.....<<<...<..<<<<<<.<<<<<<<<..<..<<<<<<<<<..>>>>>>>>>>.>>>>.....>>>>.....<<<<.<<<<<.....>>>>>..>>>>>>>>.>>..>..>>.>.....>>.>>>>>>...>>>>>>>.....<<<<<<.<<<......>>>.>>>>>>....<<<......>>>...<<<<<.<<...<<<(((.....<<<<<<.....<<......<<..<<<<<<<........<<<<<<.<....<<<<.......>>>>....>........<<<......>>>..>>>>>>......>>>>>>>.>>...........)))>>...>>>>>>.>>>...>>>>>>><<<<..<<<<<<<<<<<<....>>>>>>>>>>>>...>>>>....>>>>>>..<<<<<<..<<<....<<..<<..<<...>>..>>..>>....>>>.>>>>>>........>>>>>><......<<.....<<<.<<<<<<<<<<<.....>>>>>>>>>>>.>>><<<<<...<<<<<.<<........((...<<<.<<<...<<<.<<<<<<<..>>>>>>>>>>...>>>....)).........<<<.<<..(((((..>>.>>>..............>>>..>>......<<......>>>>>>>..<<<.....>>>..>>>>>....<<<<....<<<<<<<<.<<.........<......<<.<<....<....>.....>>>>..<<<.<<...<<<<..>>>>....>>.>.>>.............<<<<<<<<<..<<<.........>>>..<<<<<<.......<<<<.....>>>>.......>>>>>>....<<.<<<..<<<<<<<..<<....<.......<<<<<<<.......>>>>>>>.......>....>>>>>>>..>>>>><<<<<........>>>>>........<...........<<<<<<.....>>>>>>.....>....>>.....>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<..<<<.[[......<<<<.[[<<<<..<<<<<..<<<<<.<<..<<<<<<<<...<<<<<...........<<<<<<.<<<.....>>>...........>>>>>>..>>>>>.>>>>>>>>......<<<<.....>>>>....>>.>>>>>...>>>>>...<<.......>>.<<<<<<...........>>>>.>>..<<.....<.......<<<..<<<<...>>>>..>>>.>..........<<<<<<.......>>>>>>.............<<<<<<<<<......>>>>>>>>>................<<<<<<<.....<<<<.........>>>>.<<<<..<<<<<<<.<<<.<..<<<<<..>>>>>.>>>>.>>>.>>>>...<<<<<<<<<..>>>>>>>>>........>>>>......<<<...(((>>>...>>>>>>>...<<<<..<<<.........>>>..>>>>.<<<....>>>.>>))).......<<<<<<.(...>>>>...)>>>>>>............>>>>..]]>>>>.......<<<<.<...<<<<<...<.........>...>>>>>....>>>>.>.......<<<<<.<<<<<...<<<<<<<<.........>>>>>..>>>..<<<<.....>>>>.......>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..>>>.>>>>>>>.....<<<<<<...<<<<<...<<<<<...............>.>>......<<<<<..>>>>>>>.<<<<<<...<<<<...<<<<<<<<<<<<<<.<<<..>>>...<<<<...)))))..>>>>........>>>>>>>>>..>>>>>...>>>>.>>>>>>..<<<.<..<<<<<...........>>>>>...>>>>.>>>>>...>>>.>>>....<<<.<<<<<.......>>>>>....<<<<<<<<<<<<.....<<<<....>>>>....>>>.>>>>>>.>>>.....>>>....>>>>>>>>.....>>>>>>>>>>. ((((..((((((.......(((((((((..))))...(((..(....((((((((((...[.(((....((((((((((.(((((..{..[.)...[.((((((...........}.]].))))))....))))..((....))..........((((((.....(......)......))))).).........((....))...(((((.....((....))....)))))...(((..............(((((((......)))))))........(((((..{{{{)))))..)))......))))))))).)...............((....))....)).).....)))))))))).....(.((((..((.........))..)))).{.(.(........).).((((((....(((((((((((((..((...........))...(......)..((((.......))))...)))))))))))))..((.(...((((((.....((((((((((.((((......){)))...(((..((((.......A)))).)))..).))))))))).(...((.....))....)..))))))....).))..((((((....(((((....)))))...((((((..(((((((.((.....(((...(..((((((.((((((((.....((((((((....))))))))..)))).....))))......(((.(.(((.....))).)..))).)))).))..)..)).).....)).))))))..)))))))......((((((.(((......))).))))))....(((......)))...(((((.((...((([[[...(.((((((.....((......((..(((((((.......<((((((......(((.........)))..........(..(((......)))).))))))......))))))).))...........]]]))...))))))))))...)))))))(((((.((((((((((((....)))))))))))).).))))....))))))(.((((((..(((.....(.]((..((...))..))..).....))).))))))..).....))))))(......((.....(((.(((((((((((.....))))))))))).)))((((....((((..((.(......[[...(((.(((.(.(((.((((((....)))))))))..))))....]](........(((.((..[[[[[..)).))).(..).......).))).)))......((......)).))))..((.......))...))))....((((....((((((((.((..(....(........((.((....(.[..).....))))..(((.((..(((((..)))).<).)).).)).(...).......(((((((((.}.((.........))...((((((........(((.....)))........)))))).]..((.(((..(((((((..((....(.......(((((((.......))))))).......)....)))))))..)))))(((((........)))))........((..........((((((.....))))))..)..)....)).....)).))))))).)..))).)))))))).)))))).....)).[..(((((.....}].)))))..(((((((..(((.((......((((.((((((..(((((..(((((.((..((((((((...(((((.(......[..(((((..(((.....)))..........].)))))).))))).))))))))......((((.....))))....)).)))))...)))))...((.......)).((.(((...........)))..))(.((.....(.......(((..((((...))))..))).)......(...((((((.......))))))...........).(.((.(((........))).)).)................(((((((..((.((((.........)))).((((..((..(((.(((.((.((.((..)).))))))).))..).))...(((((((((())))))))))........))))....)).((...[[[))....)))))))...((((..(((......<..)))..)))).(((....))).))]]].......((((((.(...}}}}...)))))))......)>....))))..))))))......(((((.(...(((((...((.......))...)))))....)))).).).....(((((.(((((...((((((((.........)))))..)))..((((.....)))).......))))..)...))).))....(((((((....))).))))..a.))..))).)))))))....)((((((...(((((...((((......(....)......))......(((((..))))))).((((((...((((...((((((((((((((.(((()))).(.((((...]]]]]..)))).....)>.)))))))))..)))))...)))).))))))..(((....(((((....>......)))))....))).)))))...))).)))....(((.(((((.......)))))....((((((((((((.....((((....))))....))).)))))).))).....)))....)))))))).....)))))))))). The structure of the mitoribosome from Neurospora crassa with bound tRNA at the P-site; 23S rRNA 6ywy aa 1435 3.05 RF00177,RF01959,RF01960 URS00021ED984_5141 33056988 0003735 0005840 5141 auagaugaguuuggugauggcucugauugaacacuguccaaauacuugacacaugcuaaucgaacguuuaauuuuggcucuuaauuaaaagugguguacaggugaguauaauauuuuuucgcuuaacuuaaagugaaggcaaauccuucauauugcaaaaggauaucuauauccgcuuuaagaggaugagaaaaguuucagagauagguaguuguuaaggucauggcuuaacaagccaauaauucucuuagucgaagcugaaaaggcugaucgaccacauugggaaugaaaaaaucccaaggcaaauagguacagcagugaggaaucuuggucaaugggcccacgccugaacugguaacuuggaggaaugagacgucgauuuaucgaguaaaauucuguauacauauugauaaugacaauauguacauuugucuugacuaauuacgugccagcagucgcggcaauacguaagagacuaguguuaaucaucauaaauagguuuaaaggguacucagacggaaaaauucgcccaaauauaggggacaauuuuucuagaguuuuauguaagaaggucguacucuagaguggagagauaaaauucugugauaccuaggggacggguaaaggcgaaggcaaucuuuuauguaaaaacugacgucgaaggacgaaggcaaagggaacaaaaaggauuagauaccccaguagucuuugcagacaauuaugaaugccauagguuagauuuuuaauuuagucuauaaaugaaaguguaagcauuucaccucaagaguaaggcggcaacgcaggaacugaaaucacuagaccguuucugacaccagcaaugaaguauguuauuuaauucggugacccacgaaaaaccuuaccacaauuugaauauuaauuauuaauacaaguguugcacggcugucuucaguugauguugcgaaacugugguucguuccauggaauuaacguaaacccuugcuuuauuuguaaauauuauaaagcaguucaccuuuauauaggaaaugauaaaagggaucaagacaagucaucauggccuaaauauugugggcuauagacgugccacauuuuccuaaacaaagagaugcaaaaaugugaauuuuagcuaaucucaaaaaauaggauaaaaauauacaaggauuguagucugaaauucgacugcaugaauaagaaauugcuaguaaucgugaaucaccaugacacggugaauauucccucggauugguacuaaccacucgucacaugcugaaaggagugcgugcaauaaguuugcuuuucuguuauaaguaaguagacauauagguuuagauguuauaauaggauccuucguaugcgcggcucugauuaguguuaagucgaaauacgguucguguaguggaaguugcacgggacuuaucaauguugaacaauacga ......((((..<<<<<<.))))<<<<<.<<<<<..<<<<<.<<.....<<<.<<<..<<<..<<.<<<<<<<..<<.>>..>>>>>>>.>>>>>......<<.........<<<<<<<..<<...<<<<<<<<<<<<<.....>>>>>...........<<<<<<..>>>>>>>>>>>>>>.>>....>>>>>>>...<<<<<..<<<..<<<<<<<<.......>>>>>>>>>>>......>>>>>..<<<<.<<<<.....>>>>...>>>>.>>.<<<<<...........>>>>>.<<......>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>..>>>>>.<<<<......<<<<<..>>>>>.....>>>>....<<<<<<<<<.......>>>>>>>>>.....<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>>.........<<<((.....<<..<..<<<.<<<<<<<<.<<<<.......>>>..>>>>>>>>>...<<<<<......<<<<<<<.<..<<<<<<.<<<..<<<......>>>.....>>>>>>>>>..>........<<....>>.>>>>>>>......>>>>>...>>>...>.>>....<<<<<<...<<.....<<.........>>.....>>>>>>>>..........<<<<<<.<<<<<<<<<<<<...>>>>>>>>>>>>..<<..))>>....>>>>>>.>>>.<<........<<<....>>>......>>..>>>>>><<<<<...<<<<<....<<<<<<...<<<<<<<<<......<<........>>..........<<<<<<<.....<<<<<<<.>>>>>>>..<<.<<...<.<<<<<<<....<<<<<<<<<....>>>.<<<<......>>>>...>>>>>>.....<<<<<<<<<<<<...........>>>>>>>>..<<.<<<......>>>....>>....>>>>.....>>>.>>>...>.>.>>>>....>>>>>>>...>>.>>>>>>>.......<<<<<......<<<..<...<<<<....>>>>...>....>>>......>>>>>............<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<...........>>>>>>..........>>>>>..>>>.>>....<.<<<.<..<<<<<<<..<<<<<.<<<<<<....<.......<<<<<<<<<<<.....<<<<<......>>>>>....>>>>>>>>>>>.....>...>>>>>>>>>>>..>>>>>>>...>.>>>..>.....<<<<<<<<<....>>>>>>>>>......................... ......[[[[..(((((..]]]].((((.(((((..(((((.(((....(((.(((..(((..((.((((((...(...)...)))))).)))))......(((......(.((((((((.((...(((((((((.(((.....))).)...........((((((..)))))))))))))).))..)[))))))))..(((((..(((..((((((((....]..)))))))))))......)))))..((((.((((.....))))...))))))).((((((.........)))))).((......))...)))))).).....(.(((...(((((....)))).))))).))..))))).((((......((((....)))).....))))....(((((((((.......))))))))).....((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((.....(((.((((((((.((((.......)))..)))))))))..((((((.......((((((((..((((((.((...((........))......))))))))..)).......((....)).)))))).......)))))..)))).....))....((((((...((.....((.........)).....))))))))......{...((((((.((((((((((((...))))))))))))..((..]]))....)))))))))).((........(((....)))......))...)))))(((((...(((((.(...(((((...(((((((((......((........))..........(((((((..(..(((((((.)))))))).((.(((....(((((((....(((((((((....))).((((......))))...)))))).....(((.((((((((...........))))))))..((.(((......)))....)).....))).....))).)))...)..)))))....)))))))...)).)))))))..(....(((((......(((..((...(((....)))...))....)))......)))))............(....(((((((........)))))))....)..)..))))).....((((((...........))))))......)...)))))..))).))..(.(..((.(..(((((((..(((((.((((((....(...(...(((((((((((.....(((((......)))))....)))))))))))..)..)...)))))))))))..)))))))...).))...)..)..(((((((((....)))))))))}......(...)............. The structure of the mitoribosome from Neurospora crassa with bound tRNA at the P-site; 16S rRNA 6ywy bb 73 3.05 RF00005 URS00021ED924_5141 33056988 0030533 0006412 5141 ggcugaguagcucaaaguagagcauaccguucaaaacgguaaugaauguguucgauccacagcucagccacca <<<<<<<..<<<<......>>>><<<<<<<.....>>>>>>.>...<<<<.......>>>>.>>>>>>>.... (((((((..((((...[[.)))).(((((.......)))))...].((((..]....)))).))))))).... The structure of the mitoribosome from Neurospora crassa with bound tRNA at the P-site; P-site-tRNA 6ywy ee 11 3.05 33056988 5141 aauauuuuugu ........... ........... The structure of the mitoribosome from Neurospora crassa with bound tRNA at the P-site; mRNA 6yyt P 14 2.9 URS0001A24B72_32630 32438371 32630 caugcuacgcguag .............. .............. Structure of replicating SARS-CoV-2 polymerase; RNA product 6yyt Q 14 2.9 URS0001A24B72_32630 32438371 32630 caugcuacgcguag .............. .............. Structure of replicating SARS-CoV-2 polymerase; RNA product 6yyt T 12 2.9 URS0001A24B72_32630 32438371 32630 ugcuacgcguag ............ ............ Structure of replicating SARS-CoV-2 polymerase; RNA product 6yyt U 14 2.9 URS0001A24B72_32630 32438371 32630 caugcuacgcguag .............. .............. Structure of replicating SARS-CoV-2 polymerase; RNA product 6z18 A 10 1.81 URS000080E19F_32630 32941619 32630 ccggngccgg .......... .......... Crystal structure of RNA-10mer: CCGG(N4,N4-dimethyl-C)GCCGG; R32 form; RNA-10mer: CCGG(N4,N4-dimethyl-C)GCCGG 6z18 B 10 1.81 URS000080E19F_32630 32941619 32630 ccggngccgg .......... .......... Crystal structure of RNA-10mer: CCGG(N4,N4-dimethyl-C)GCCGG; R32 form; RNA-10mer: CCGG(N4,N4-dimethyl-C)GCCGG 6z1p Aa 278 3.7 RF02541,RF02540 URS000001A9BC_312017 32553108 0003735 0005840 312017 guaguugauuuuaauacgcacuagauggaugccuagaauuuaaacuucuucguaaacaaauuuacgauaucuauuuaguaaauaacauauugauacguuuauguauuggagauuaauagauaaaguugguaaauaaugaagugaaacaucauaguaauuauuuaauaaacucaauugagaauaguauaacggugaguaaauacuauaaguuuuauuuaaauuaaaauugaaaaauuuggaaaaauuuaccauagagggugaaagucccguaaauuuac ...............................................<<<<<<<((....((>>>>....<<<.<<<<..<<<))....)).............>>>.....>>>>>>>...>>>......<<<<<<....<<<....>>>.....>>>>>>........<<....>>..<<<<<<..<<.....>>...>>>>>>.................<<<<<...<<<<<......>>>>>(.......<<<......)>>>...>>>>>.. ...............................................((((((([[....[[))))....(((.(((...(((]]....]].............)))......))))))...)))......((((((....((...[..)).....))))))........((....))...((((...((.]...))....))))..................(((((...(((((......)))))[[(...).(((.....]])))...))))).. Structure of the mitochondrial ribosome from Tetrahymena thermophila; LSU rRNA_1 6z1p Ab 2237 3.7 RF02541,RF02540 URS00002F0F94_312017 32553108 0003735 0005840 312017 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.....<<<<<<<<.......>>>>>>>>......<<<<<..((((>>>>>...................................<<....>>..........................................................<<<<<<<<......>>>>>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<...<<<..................>>>...<<....>>........>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<...<<<<<<..>>>>>>....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<....<<<<<<<<<.....<..<<.<<<<..<..<<<<<<<<....>>>>>>>>..>..>>>>..>>.>.....>>>>>>>>>..>>>>>>.>>..<<<<<<.<<<......>>>.>>>>>>....<<<......>>>...<<<..<<<...<<<(((...<<<<<<<..........<<<<<<<<....<<...<<<<<<..<<<..<<<<.......>>>>..>>>.......<<<<......>>>>..>>>>>>...<<<<<...........>>>>>..>>...>>>>>>>>...........))).......>>>>>>>>>>...>>>.>>><<<....>>>....>>>>>><<..<<<...<<....<<<<<<<<....>>>>>>>>...>>..>>>...>>.....>>>>>><......<<....<<<<<<.......>>>>>><<<<....<.<<..<....<<<<<<.............>>>>>>.......<<<.<<...<<<....<<.....>>...>>>...>>....<<<<<<<<<<...<<...<<<<<<<<.....<<<<<<<<....[[.[[.>>>>>>>>..>>>>>>>>..>>.........>>>>>>>>>>.....>>>....>....<<......>>.>>.>..<<<.....>>>...>>>>..<<<<<...<<<<<<<..<<................<<<<...............>>>>.<<......>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<......>>.......>>>>>>>.<<<<<.<<<..<<<<<<...<<<.....<<<<<<<<<....>>>>>>>>>....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>.....>>..>>>>>>>>>>>>>>.....>.....<.<<<........>>>.>..<<<<<<<<.<<<.<<<.....<<<<.<.<<<<..<<<<...<<.<<<<<<<<<<.>>>>>.<.<<<<................>>>>.>..>>>>>.>>....>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>....<<<...(((>>>...>>>>>>>...<<<<<<<<<......>>>>>>>>>.<<<....>>>.>>))).......<<<<<<.<<<..))))..>>>>>>>>>.............>>>>...>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<.<<<.<<<<<<..<<<<<<<<........>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>..>....<<<<<<<....>>>.>>>>...>>>..>>>>>>>>>>>....<<<<<<<<.<<<<<.<<<..<<<...............>>>..>>><<<<<....<<<..<<<<<<<<<<<<...]]]].>>>>>>..>>>>>>..>>>..>>>>>...<<<...<<<<<............>>>>>...>>>..>>>>>..>>>>>>>>...<<<<.<..<<.......>>..>....<<<<<<<<<<<.........<.......>......>>>>>>>>>>>....>>>>........................ .....((((((((....[..))))))))......(((((].[[[[)))))...................................((....))............(..(.......)...........)....................(.((((((((......)))))))).[.(.(........).).((((((..(.(((((((((((((..(((..................)))...((....)).......)))))))))))))..((.(...((((((.....((((((((((.((((..((((((..))))))..)<)))...(((..((((.......A)))).)))..).))))))))).(..((.....))....)..))))))......).))).((((((....(((((....)))))(((((((.....(((((((((.....(.....((((..(...(((((((....)))))))...)..)))).....).....)))))))))...))))).))..((((((.(((......))).))))))....(((......)))...(((..(((...((([[[...(((((((..........((((((((..(.((...((((((..(((..(((.........)))..))).....(..(((......))))..))))))...(((((...........)))))..)))..))))))))...........]]].......))))))))))...))).)))(((....)))....))))))(.(.(((...((....((((((((....))))))))...))..))).)..).....))))))(......((....((((((.......))))))((((...[(.((..((...((((((...(.....)...))))))......(((..((.(.(((....((.....))...)))..)))...(((((((((((...((...(((((.(......((((((((....{{{{..))))))))...).)))))..)).........))))))))))....).)))..))....((......)).)).)..(((.....)))...))))].(((((....(((((((.((..(....(........((((....(.[..).....)))).(((...).))............((((.((((.>.((.........))...(((((((......(......)........))))))).]((((.(((..(.((((...(((.....(((((((((....)))))))))....))).))))...))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).)).)))).)..))).))))))).))))))).....))....(.(((.....]..))).)..((((((((.(((.(((.....((((.((((((..(((((..((.(((((.((((.))))..(.((((................)))).)..))))).))...)))))..(((......[)))((((((..........]))))))([((...((((((.(..((((((.......)))))).....((][.[[[))....)))))))...((((.((((...{..)))).)))).(((....))).))]]].].....((((((.(((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....((.((.((((((..((((((((........)))))..))).(((((.....))))).....)))))..)...))..))....(((((((....))).))))..a)))..)))))))))))....((((((((.(((((..((..(((.....(....)....)))..)).(((((...((((..((((((((((((...}}}}.))))))..))))))..)))).)))))...(((...((((..............))))...)))..)))))..))))))))....(((((..((.......))..)(....((((((((((.........(.......)......))))))))))..)).)))......................... Structure of the mitochondrial ribosome from Tetrahymena thermophila; LSU rRNA_2 6z1p Ba 196 3.7 RF00177 URS0001A24B40_312017 32553108 0003735 0005840 312017 aaaauaaaaaaaaaauuuauugagugugaucauggcucgggauuaacgcuaauuagacgccuaacacaugcgaguuuuauaugaguuaaauuaaaauuuuauuuaaacauauagcgucaaggugaguaauauacaaauauaugccuuuaagccuacuuaaauagacgguaacuuuaaaacaguaacaaauguacua ....................<<<<<.........>>>>>..................................<<<..<<<<<..<<<<<<.........>>>>>>.>>>>>>>>.....................................<..<<.....>>..>.....<<.........>>........... .....................((((.........))))...................................(((..((((..(((((((.........)))))).)))))))).....................................(..((.....))..).....((.........))........... Structure of the mitochondrial ribosome from Tetrahymena thermophila; SSU rRNA_1 6z1p Bb 1385 3.7 RF00177,RF01959,RF01960 URS0000308AD7_312017 32553108 0003735 0005840 312017 uguuuacagcuuaaagauuauuuuguacaauauuagguaauuauuucuaaaacuguuuaauaauauuauuuuuaguaaaauaagccuagauguuuaguugaauuuagagauuguucaaccacauacggguaugaaaacuacccuaucuuuuugacagcagugaggaauuuuggacaauaugcgaaagcaugauccagcgaacuaauggaaacgaagaagauagcaauauuguaaaguuuagugcgagaauuaacaaaugaguaaauucuaggagaagcucuggcuaauacaugugccagcagccgcgguaauacaugaggagcaagcguuacccacauugacuggguguauuaaauacauaggugauuacaaauacuacuuuaaaagucaauuaaaaaccuaauauaguaguuuuuuuguaaaugauaauuaaauauaaggauaggagauuuauagaacaacgauuaaauguaguuacacuauagagcuugccauaaacuaaggugcuuuccuauauuuaauuauagcugauguaugaaaguacggggaucgauaaggauuaguuucccuaguaguccguacuguaaaagaugaauacuucaugaauuaaauauucagggauagcuaacgcaaaguauucuacucggggaguauaaucgcaagauuaaaacuuaacugaauuggcgggaauuuguucgaacgguggaacaugugguuuaaugcgauaauccacgcaaaaucuuaccaacguuucaggcuuuaucaguaguaugauuaauaucaaaauuauaugauuuaguacggaauugcauggcugucgucaguucgugcugugaaguuuaggauuaaguucuuuuuaacgaaugcaacccuauaaguaaguuuuuauuuuaaaauaacuuaauuuuuuaaauauacuuauuuaaucuauaauuagaauauauugaaucuauucuguauauucuuuuauagggguuauaggcugaagucaagucccuauggucuuuauacguugggcuacacacguguuacaaggguaaauacaaaaagacgcaaaaaaguaauuuugagcaaaccuuuaaaaauuaccuuaguucagauuguuuuaugaaauucuaaaacaugaagaugaaaucguuaguaauuguaaauuauuauguuacagugaaacaauagucaaauuuugcacacaccgcccaucacgcucggaaagucaauaauagcggaagauuugaaaaacucugcgcaaaacuaauauuauuuuuauauuaguuggcauuauauuauuuuuuaauggcaugguugaaaaguaguauccaaucuaguauugguaauuugagugaaguugacacaagguacugguaggggaaccuguugguggaaua ............................<<<....<<<..<<<<<<<<<<<.......<<<<....>>>>>>>>>..>>>>>>>>>.....>>>..<<<<<<<<....>>>>...>>>>....<<.<<<<.........>>>>>><<.....>>.................<<<...<<<<<....>>>>.>>>>.............<<<<......<<<<....>>>>.....>>>>......<<<<<..<........>..>>>>>.......<<<<<(((.....<<<<.....<<.)))>>.......>>>>.>>>>>.....................<<<((.....<<<<<..<<<.<<<<<<<<..<<<<<.<<....................>>.>>>>>....>>>>>>.>>..<<<<<<<<<<<.<<<<.<<<<<.<<<<<<<....<<<......>>>.......>>>>>>.>>>>.......<<....>>.>>.>>>>>>>>>>>>>>>..>>>..>>>>>...<<<<<<<<...<....<<<.........>>>....>>>>>>>>>.........<<<<<<.<<.<<<<.......>>>>..>>..<<..))>>...>>>>>>.>>>.<<<.....<<<<<....>>>>>...>>>.........<<<<.<<<<<<<.....<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<.....<<<..<<<..<<<..<<<<....>>>>...>>>...>>>..>>>..<<.<<<..<<<<<<.......<<<<<<<<<....>>>...<<<......>>>.....>>>>>>.....<<<.<<<<<<<<....<<<<<.<<<<.........>>>>.>>>>>..>>>>>>>>..<<<<<<...<<<<<<<<.<<......>>.>>>>>>>>..>>>>>>.......>>>.........>>>...>>>>>>>>....>>>>>>>...>>.>>>>>>>>.....<<<<<.<....<<<<..<<..<<<<....>>>>..>>....>>>>....>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>.....<<<<<<<.........>>>>>>>...........>>>>>>>>>>.>........<<.<.<<<<<<<<..<<<<<<<.<<<.....<<<.<......<.<<<.<<..<<<<<<<<<.......>>>>>>>>>.......<...........>..>>.>>>..>.......>.>>>....>>>.>>>>>>>..>>>>>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>...... ............................(((....(((...((((((((((.......((((....)))))))))..))))).))).....)))..((((((((....))))...))))....((.((((.........))))))((.....))...............(.(((...(((((....)))).)))))............((((......((((....)))).....))))......(((((..((......))..))))).......((((([[[...(.((((.....((.]]])).......)))))))))).....................((([[...(.((((...(((.((((((((..((((..((....................))..))))....)))))).))..(((((((((((.((((.(((((.(.(((((....((........)).......))))).).))).......((....)).)).))))))))))))))..))))...))))....((((((....(....(((.........)))....).))))))..........((((((.((.(((((.....)))))..))..((..]]))...)))))))))).(((......((((....))))....)))..........(((.(((((((.....(((((..((((((.(((......((........))..........(((((((.....(((..(((..((((.(((......)))..))))...)))..)))..((.(((...(.((((.(....(((((((((....)))...(((......))).....)))))).....((((((((((((....(((((.((((.........)))).)))))..))))))))...(((((..(.(((((((.((......)).))))))).).))))).......)))).....).).)))....).)))).)...)))))))...)).).)))))).(...(((((.......(((..((...(((....)))...))....)))......)))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))...........)))))))))).....(.(..((.(.((((((((..(((((((.(((.....(((.(......(.(........((((((((.......))))))))..........(.(...)..)........)..).......).)))....))).)))))))..))))))))..).))...)..)..(((((((((....)))))))))...... Structure of the mitochondrial ribosome from Tetrahymena thermophila; SSU rRNA_2 6z6b CCC 16 3.961 URS00021ED936_3052409 32681014 3052409 uuaguaguacacuacu ................ ................ Structure of full-length La Crosse virus L protein (polymerase); RNA (5'-R(P*UP*UP*AP*GP*UP*AP*GP*UP*AP*CP*AP*CP*UP*AP*CP*U)-3') 6z6b HHH 16 3.961 URS00021ED936_3052409 32681014 3052409 uuaguaguacacuacu ................ ................ Structure of full-length La Crosse virus L protein (polymerase); RNA (5'-R(P*UP*UP*AP*GP*UP*AP*GP*UP*AP*CP*AP*CP*UP*AP*CP*U)-3') 6z6g H 13 3.06 URS0000868514_2560547 32681014 2560547 guaguacacuacu ............. ............. Cryo-EM structure of La Crosse virus polymerase at pre-initiation stage; 3'vRNA 1-16 6z6j C2 1700 3.4 RF01960,RF01959,RF00177 URS00005F2C2D_559292 32687489 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaaauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccucuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuaacggggccuuuccuucuggcuaaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<.......>>...>>.>>......{{........[[[..{{..{{....[[[...............<<....<<.<<<.....>>>.>>.....>>.........<<<<<..<......>..>>>>>[...((((((......<<<<<<<<<<<<..>>>>....<<......>>)))))).....]...<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<<<<....>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.[[....<<<<<<.<<..>>.>>>>>>....<<<<<<.....>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[.[..(((((((.....>>>>>>>>..))))))).].].....]]....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<<.....>.>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>.<.<<.<<<..<<<<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>...>.>>>>>>>>....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<.....>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((.......))...)){))......(((.......(((..((..((....(((...............((....((.(((.....))).)).....)).........(((((...(....)...)))))(.(.((((((......[[[[[[[[((((..)))).....(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).((.....(((....((((((((.......))))))))))).......))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(.(((((.(..).)))).).)....(.(((.(...........)).))......)..((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.((())).))))))....(.((((.....)))).)...(((((.((.......((..((.......)).(((.....)))....))......)).))..)))..........((..((((((((....]]]]]]]].)))))))).))......))...((((.((..(...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)..))..)))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((.((((((..(((.((((((......((........))..........((((...(...(((((........((.(((........))).))......)))))....(.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((..(((((....)))))....)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))......)..))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))))....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...(((((...)))))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>........ Cryo-EM structure of yeast Lso2 bound to 80S ribosomes under native condition; 18S rRNA 6z6j C1 3127 3.4 RF02540,RF02543 URS000061F377_559292 32687489 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguuaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[...........<<.<<<<<<...>>>>>>.>>.............<<<<<<.<<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<......<<<<<<<<<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>....>>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<......<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>....>>>>>>.>>>>..>>>>>>><<<<<<<<<......>>>>>>>>>....>>>>>><.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<.<<...>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>...<...<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<<....>>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>...>......>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<..>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<....<<<<<....>>>>.>...>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<...>>>>>>>...<<<<<.....<<<<..<<<..........>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>....<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((.(((...))).)).))....)........((.(((.(((((((((((((((((((.(...({((((......)))))[[(...).(((....}]])))....).))))))..))))))))....)))))))).))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.(((((......((((((((((((((.((((((((.......(((((((......(((((.(...)))))).......))))))).....))))).))).))))))........(((....)))....)))))))).....))))).))))).[((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...(.((((.....)))).).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((.(.(((...((.........))...))).....(...((......)).)..))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((......)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((.(..((..(((((((...((.....)).))))))....[[(((.((...((....(((....)))........(..((...)).)....))....))...(((((........)))))]]((((..(((((.(...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....).))..))).)))).))).))).....((......)).).)).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((..)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...(......((((....))))......).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..((.(((.....))).))...(((((.....((((..(((..........)))...........>....(((((....)))))...))))..))))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(...((((((...((.......))...))))))....).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....))))))))....(.((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...((.((.(..(((......)))..).)).)).)))))).............)).))).)))).)..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Cryo-EM structure of yeast Lso2 bound to 80S ribosomes under native condition; 25S rRNA 6z6j C4 121 3.4 RF00001 URS000055688D_559292 32687489 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Cryo-EM structure of yeast Lso2 bound to 80S ribosomes under native condition; 5S rRNA 6z6j C3 157 3.4 RF00002 URS00001BF64E_559292 32687489 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauu .........................................<<<<<<<<<....>>>>.....<.<<<......>>..............>>>..>...>>>....<<.....>><<<<<<<<<....>>>>>>>>>.................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....))))))))).................... Cryo-EM structure of yeast Lso2 bound to 80S ribosomes under native condition; 5.8S rRNA 6z6k C2 1700 3.4 RF01960,RF01959,RF00177 URS00005F2C2D_559292 32687489 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaaauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccucuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuaacggggccuuuccuucuggcuaaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<.......>>...>>.>>......{{........[[[..{{..{{....[[[...............<<....<<.<<<.....>>>.>>.....>>.........<<<<<..<<....>>..>>>>>[...((((((......<<<<<<<<<<<<..>>>>....<<......>>)))))).....]...<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<<<<....>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.{{....<<<<<<.<<..>>.>>>>>>....<<<<<<.....>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[[..(((((((.....>>>>>>>>..))))))).]]].....}}....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<.<<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>>....>.>>>>>...>>.>>>>.>>>.>...<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<.....>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((.......))...)){))......(((.......(((..((..((....(((...............((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[[[[[[[((((..)))).....(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(((((((.(..).)))).)))....(.(((.(...........)).))......)..((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.((())).))))))....(.((((.....)))).)...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(((..((((((((....]]]]]]]].)))))))).))).....))...(((((((..(...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)..))).)))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((.((((.((((((......((........))..........(((((.(....(((((........((.(((........))).))......)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((..(((((....)))))....)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))).)..)).)))).))).)...(((((((......((.....((..(.((....)).)..))....)).......)))))))......(....((((((..........))))))....).....))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...(((((...)))))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>........ Cryo-EM structure of yeast reconstituted Lso2 bound to 80S ribosomes; 18S rRNA 6z6k C1 3127 3.4 RF02540,RF02543 URS000061F377_559292 32687489 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguuaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>...{.....<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<.<<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]....}.............................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<......<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<......>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<..<.<<<<...<<<<<<.....>>>>>>.>>>>.>..>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<......<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>....>>>>>>.>>>>..>>>>>>><<<<<<<<<......>>>>>>>>>....>>>>>><.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<....>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<<....>>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<.<<<<<<<<<<<..>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<....<<<<<....>>>>.>...>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<...>>>>>>>...<<<<<.....<<<<..<<<<........>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<...<<<<<<<<<<<}}}.>>>>>..>>>>>>..>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>....<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<.<..<<<<<......>>>>>..>>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.((((((((.((((((((.(((...({((((......)))))[[(...).(((....}]])))....))).))))..)))).)))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((......((((((....)))))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).<((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...(.((((.....)))).).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))((((((((........))))))))....))))))((((((((((.((......((((.((((....))))))))...)))))))))).)).....))))))((.....((.....((((((.......))))))((((.....((((..((..(((((((...((.....)).))))))....[[(((.((...((....(((....)))........(..((...)).)....))....))...(((((........)))))]]((((..(((((((...((((....)))...(.[[((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).))).))).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((..)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((...)))))))...(((((.....((((..(((.(......).)))..........]]...((((((....))))))..))))..))))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....))))))))....((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Cryo-EM structure of yeast reconstituted Lso2 bound to 80S ribosomes; 25S rRNA 6z6k C4 121 3.4 RF00001 URS000055688D_559292 32687489 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Cryo-EM structure of yeast reconstituted Lso2 bound to 80S ribosomes; 5S rRNA 6z6k C3 157 3.4 RF00002 URS00001BF64E_559292 32687489 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>.................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....))))))))).................... Cryo-EM structure of yeast reconstituted Lso2 bound to 80S ribosomes; 5.8S rRNA 6z6l L5 3772 3.0 RF02543,RF02540 URS000075EC78_9606 32687489 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcggcccggcggaucuuucccgcgcgggggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucgggggcccccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcgcucuccccccucccggcgcgccggggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccgggggaggccacgcgcgcgucccccgaagagggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcagacccgacgcccgccacgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagcggcggccggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcugggucggucgcggccggcgccuagcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacaugagagguguagaauaagugggaggcccccggcgcccccccgguguccccgcgaggggcccggggcgggguccgccggcccugcgggccgccggugaaauaccacuacucugaucguuuuuucacugacccggugaggcgggggggcgagccccgaggggcucucgcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccggucccccgccgggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>>..<<<<<<<<<<...<<<<<<<<........<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>...>>>>>>>>..>>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<<<..<<<<<<<...<<..<<....<<<<.<<<..<<<<..>>>>>>>>>>>>>..>>..>>>>...>>>>>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<.<<<<<<<<<<<<<<<...<<..<<<.<<.<<<<......<<<<<<<<..>>>>>>>>.......>>>>.>>>>>........>>>>>>..>>>>>>>>>>>....................<<<<<<.<<<<<<<............>>>>>>>.<<<<<<.<<<<.<<<<<<<<<<<.<<<<..<<<<..<...........>...>>>>..>>>>.>.>>>>>>>.>>>...>>>>..>>>>.>>..<<<<<<<<<<.....>>>>>>>>.>>....>>>>>>......>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<......>>>>>>>..<<<<<...<<<..<<<..((((.{.[[>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<......................<<<.<<<<<<<<<...<<<....<<<..<.<<<.....<.............>...>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.........>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<.....................>>......................>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<..........]].}.))))...<....>..................>>>>>>>>>....>>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<.<.<....>>.>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<..<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<...............>>>>><<.<<<<<<<<<<<..<<..........>>.......>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>>.<<<<<.......>>>>>.........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<<<<<<....................................<........................>.................................................>>.>>>>>>>>>>...<<<<<.....<<<<........<........>...................<<<<<<<<<<.......>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>><<<<....>>>>>>)))].....<<<<<<<..<<<..)))))).>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<]]].>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.....<<<<<<<.<<..<<<<....<<<........<<<<<.<<<<....>>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>..............>>>>..>>>>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<....<<<<<......>>>>>...>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((...((((((((((.....)))))).)))).....)))....((((((((((...((((((((...(....((((((((..({((((......)))))....[[(...).(((...A}]])))...).))))))))..))))))))..))))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....(((((((((((..(((((((...((..((....((((.((...((.(..).)).))))))))..))..))))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((.(..((((......(.((((((())))))).).......))))..))))........))))))..)))))))))))...........[........((((((.((((((.....(.....)..)))))).((((((.((((.(((((((((((.((((..(((..(..............)..)))..)))).).))))))).)))...))))..)))).))..((((((((((.....)))))))).))..[.)))))).....))).)))))...)))))...)))))))).<((((........))))((((((....(((((((((((((..(((..(((((........))))..)..)))...((....))...(((((((......)))))))..(((((...(((..(((..[......[[)))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......B)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((......................(((.((((((((....(((....(((..(.(((..(..................).))).)..)))..)).)....))))))...(((((((((.(......))))))))))....))))))))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.....{.(((.(.................................(.(........).)..))))...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((..........]]......]]..(.....)......]..........)))))))))....)))))).(.((((((((.((a.....((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...((....(((....)))..........((.((((....(....)...))))))......))....))...(((((........)))))]]((((....(((((...((.((((....)))).))..((((....)))...(...((((((...(((((((((((((((((((((((..{{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....(((((((.......))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((...(([...)...])........)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(..(((.....((((....)))).....))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.(.......((((.((((((..(((((.(((((((((.(((((((..(....................................................................................................................)..)))))))...(((((.....((((.....((............))................((((((((((.......))))))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..b..)..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}}.)))))..)).))...))))...)))).((((...((((.....}.......))))...))))..)))...).)))))).....((((((..((..((((.(..(((........(((((.((((.(.))))).))))).......)))...(((..(((.....((((.(((((((......)))))))))))....)))..)))...........)..))))..)).))))))(((((.(..(.......)..)....((.(((((((.((.....((((.(..(((((......)))))..)))))....))....)))).))).))..))))).. Cryo-EM structure of human CCDC124 bound to 80S ribosomes; 28S rRNA 6z6l L7 120 3.0 RF00001 URS00000F9D45_9606 32687489 0003735 0005840 9606 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. Cryo-EM structure of human CCDC124 bound to 80S ribosomes; 5S rRNA 6z6l L8 156 3.0 RF00002 URS0000005270_9606 32687489 0003735 0005840 9606 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<<<<....>>>>.....<.<<<......>>.............>>>..>...>>>....<<....>><<<<<<<<<.....>>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))((((((((.......)))))))).................... Cryo-EM structure of human CCDC124 bound to 80S ribosomes; 5.8S rRNA 6z6l S2 1740 3.0 RF01960,RF01959,RF00177 URS00005A14E2_9606 32687489 0003735 0005840 9606 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucgcuccucucccacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgccccccguggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcgggcguccccgcccucucggccggggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggucggcccacggcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<....<<....<<<<<..................<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<<.....>.>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<<......>>>>>>>>.>>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....<......<<.<<<....>>>.>>........>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<.......................<<................>>...<<<<<<.<.......<<...<.......>.<<<<.......>>>>...>>......>.>>>..>>>........<.<<.<<<.<<<...............>>>.>>>.>>.>....>>....<<<<<<..<...<<<<..<<<.<<<<<<<<...<<<......>>>......>>>>>>>>.>>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<......<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<.......>>>>.>>>>.....>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.......>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>............<<<<<..........>>>>>...........>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<...<<.....................>>.....>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..((....(((((...((.............((.....((.(((.....))).))......))......)).((((...((((........))))...))))((..(((((...(......)..)))))......)).(.((((.((((......))))))))))).)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).).....(..((..((.(((....))).))...).)..)......((..(...........)..)).........((((([[....(.((((.....((..]])).......))))))))))..)))))).)))..[......(.([[...(.(.((...(((..(.......................((................))...((((((.(.......((..((.......)).(((.......)))....))......).)))..)))........(.((.(.(..((...............))..).).)).)....)....(((..((..(...((((..(((.((((((((...((........))......)))))))).))).......((....))...))))..)..))...))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.((((......)))))))))).)..)))...((..]]))...))...].))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))....(.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((...(...((((..((((((((((((.......)))).)))).....))))..))))..).....(((((.....)))))........)))....))).))).....).))))......).)))))...)).)))).))).(...((.(((........(.......((..((((....))))..))....).........))).))......(.....(((((..........))))).....)..)..))))).....(((((.((.......)).)))))......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..((((.((...((.((....(...(............)....)......)).))...)).))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}........ Cryo-EM structure of human CCDC124 bound to 80S ribosomes; 18S rRNA 6z6l CC 75 3.0 RF00005 URS0000E60BA3_9606 32687489 0030533 0006412 9606 uccgauauagcguaacggcuaucacaucacgcuuucaccguggagaccgggguucgacuccccguaucggagcca <<<<<<<....<..........>...<<<<<.......>>>>>....<<<<<.......>>>>>>>>>>>>.... (((((((..(.(.....[....).).(((((.......)))).)...(((((..]....)))))))))))).... Cryo-EM structure of human CCDC124 bound to 80S ribosomes; tRNA 6z6m L5 3772 3.1 RF02543,RF02540 URS0000E60B81_9606 32687489 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcggcccggcggaucuuucccgcgcgggggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucgggggcccccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcgcucuccccccucccggcgcgccggggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccgggggaggccacgcgcgcgucccccgaagagggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcagacccgacgcccgccacgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagcggcggccggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcugggucggucgcggccggcgccuagcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacaugagagguguagaauaagugggaggcccccggcgcccccccgguguccccgcgaggggcccggggcgggguccgccggcccugcgggccgccggugaaauaccacuacucugaucguuuuuucacugacccggugaggcgggggggcgagccccgaggggcucucgcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccggucccccgccgggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>>..<<<<<<<<<<...<<<<<<<<........<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>...>>>>>>>>..>>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<......>>>..................................<<<<<<<<..<<<.<....<<<<<<<<.<<<.....<<<<<<<<<<<..<<<<<<<...<...<<....<<<<.<<<..<<......>>>>>>>>>>>...>..>>>>...>>>>>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<<<<<<<<<<<<.<<<<...<<..<<<.<<.<<<<......<<<<<<<<..>>>>>>>>.......>>>>.>>>>>........>>>>>>...>>>>>>>>>>....................<<<<<<.<<<<<<<............>>>>>>>.<<<<<<.<<<<.<<<<<<<<<<<.<<<<..<<<<..<...........>...>>>>..>>>>.>.>>>>>>>.>>>...>>>>..>>>>.>>..<<<<<<<<<<.....>>>>>>>>.>>....>>>>>>.....>>>.>>>>>....>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<......>>>>>>>..<<<<<...<<<..<<<..((((.((((>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<......................<<<.<<<<<<<<<...<<<....<<<..<.<<<..<..................>.>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.........>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<..........)))).))))...<....>..................>>>>>>>>>....>>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<.<.<....>>.>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<..<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<..<<..........>>.......>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<<........................................................................<....>..........................................>>>>>>>>...<<<<<.....<<<<........<........>...................<<<<<<<<<<.......>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>><<<<....>>>>>>)))].....<<<<<<<..<<<..)))))).>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<....<<<<<.................>>>>>..<<<<....<<<<....<<.<<<<<<<]]].>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.....<<<<<<<.<<..<<<<....<<<........<<<<<.<<<<....>>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>..............>>>>..>>>>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<....<<<<<......>>>>>...>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((...((((((((((.....)))))).)))).....)))....((((((((((...((((((((...(....((((((((..({((((......)))))....[[(...).(((....}]])))...).))))))))..))))))))..))))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....(((((((((((..(((((((...((..((....((((.((....(.(..).)..))))))))..))..))))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((.(..((((........((((((())))))).........))))..))))........))))))..)))))))))))...........[........((((((.((((((.....(.....)..)))))).((((((.((((.(((((((((((.((((..((((.(..............).))))..)))).).))))))).)))...))))..)))).))..((((((((((.....)))))))).))..[.)))))).....))).)))))...)))))...)))))))).<((((........))))((((((....(((((((((((((..(((..(((((........))))..)..)))...((....))...(((((((......)))))))..(((((...(((..(((..[......[[)))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((......................(((.((((((((....(((....(((..(.(((..(..(.............).).))).)..)))..)).)....))))))...(((((((((.(......))))))))))....))))))))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((..........]]......]]..(.....)......]..........)))))))))....)))))).((((((((((.((......((((.((((....))))))))...)))))))))).)).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...((....(((....)))..........((.(((((...(....)..)))))))......))....))...(((((........)))))]]((((....(((((...((.((((....)))).))..((((....)))...(...((((((...(((((((((((((((((((((((..{{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....(((((((.......))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((...(([...)...])........)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........))))).(.)....((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.(.......((((.((((((..(((((.(((((((((.(((((.(..........................................................................................................................).)))))...(((((.....((((.....((............))................((((((((((.......))))))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a..)..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}}.)))))..)).))...))))...)))).((((...((((.....}.......))))...))))..)))...).)))))).....((((((..((..((((.(..(((........(((((.((((.(.))))).))))).......)))...(((..(((......(((.(((((((......)))))))))).....)))..)))...........)..))))..)).))))))(((((.(..(.......)..)....((.(((((((.((.....((((.(..(((((......)))))..)))))....))....)))).))).))..))))).. Cryo-EM structure of human 80S ribosomes bound to EBP1, eEF2 and SERBP1; 28S rRNA 6z6m L7 120 3.1 RF00001 URS00000F9D45_9606 32687489 0003735 0005840 9606 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. Cryo-EM structure of human 80S ribosomes bound to EBP1, eEF2 and SERBP1; 5S rRNA 6z6m L8 156 3.1 RF00002 URS0000005270_9606 32687489 0003735 0005840 9606 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<<<<....>>>>.....<.<<<......>>.............>>>..>...>>>....<<....>><<<<<<<<<.....>>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))((((((((.......)))))))).................... Cryo-EM structure of human 80S ribosomes bound to EBP1, eEF2 and SERBP1; 5.8S rRNA 6z6m S2 1740 3.1 RF01960,RF01959,RF00177 URS00005A14E2_9606 32687489 0003735 0005840 9606 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucgcuccucucccacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgccccccguggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcgggcguccccgcccucucggccggggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggucggcccacggcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<....<<....<<<<<..................<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<........>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<<......>>>>>>>>.>>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<<..>>>.>...>>>>>>.........<<<....<<<.....>>>..>>>..>...>>.>.....<.....<<<..<<....>>..>>.>......>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<.......................<<.<.............>>>...<<<<<<.<.......<<...<.......>.<<<<.......>>>>...>>......>.>>>..>>>........<.<<.<<<..<<...............>>..>>>.>>.>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<.......<<........>>........<.<<<<<.<....<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<.......>>>>.>>>>.....>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.....>.>>>>>>...>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>............<<<<<..........>>>>>...........>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<...<<.....................>>.....>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..((....(((((...((.............((.....((.(((.....))).))......))......))..(((...((((........))))...))).((..(((((...(......)..)))))......)).(.((((.((((......))))))))))).)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.(((......)))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).).....(.(((.(((.(((....))).)).).).).))......((..(...........)..)).........((((([[....(.((((.....((..]])).......))))))))))..)))))).)))..[......(.([[...(.(.((...(((..(.......................((.(.............)))...((((((.(.......((..((.......)).(((.......)))....))......).)))..)))........(.((.(.(..(.................)..).).)).)....)....(((.((...(...((((..((..((((((((...((........))......))))))))..)).......((....))...))))..)...))..))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.((((......)))))))))).)..)))...((..]]))...))...].))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))........(.(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((...(...((((..((((((((((((.......)))).)))).....))))..))))..).....(((((.....)))))........)))....))).))).....).))))).....).))))))..)).)))).))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....(.(((..(.......)..))).)......))...)))))))))).))..(.(..((.(..((((.((..(..(.(((((.(((..((((.((...((.((....(...(............)....)......)).))...)).))))..))).))))).).)..)).))))...).))...)..)..(((((((((....)))))))))}........ Cryo-EM structure of human 80S ribosomes bound to EBP1, eEF2 and SERBP1; 18S rRNA 6z6m CC 85 3.1 RF00005,RF01852 URS00021ED8EE_9606 32687489 0030533 0006412 9606 guagucguggccgagugguuaaggcgauggacuugaaauccauuggggucuccccgcgcagguucgaauccugccgacuacgcca <<<<<<<..<<<..........>>><<<<<<.......>>>>>><<<<...>>>>..<<<<<.......>>>>>>>>>>>>.... (((((((..(((.(...[.)..))).(((((.......))))).((.(....)))..(((((..]....)))))))))))).... Cryo-EM structure of human 80S ribosomes bound to EBP1, eEF2 and SERBP1; tRNA 6z6n L5 3772 2.9 RF02543,RF02540 URS000075EC78_9606 32687489 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcggcccggcggaucuuucccgcgcgggggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucgggggcccccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcgcucuccccccucccggcgcgccggggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccgggggaggccacgcgcgcgucccccgaagagggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcagacccgacgcccgccacgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagcggcggccggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcugggucggucgcggccggcgccuagcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacaugagagguguagaauaagugggaggcccccggcgcccccccgguguccccgcgaggggcccggggcgggguccgccggcccugcgggccgccggugaaauaccacuacucugaucguuuuuucacugacccggugaggcgggggggcgagccccgaggggcucucgcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccggucccccgccgggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>>..<<<<<<<<<<...<<<<<<<<........<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>...>>>>>>>>..>>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<<<..<<<<<<<...<...<<....<<<<.<<<..<<<....>>>>>>>>>>>>...>..>>>>...>>>>>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<<<<<<<<<<<<.<<<<...<<..<<<.<<.<<<<......<<<<<<<<..>>>>>>>>.......>>>>.>>>>>........>>>>>>...>>>>>>>>>>....................<<<<<<.<<<<<<<............>>>>>>>.<<<<<<.<<<<.<<<<<<<<<<<.<<<<..<<<<..<...........>...>>>>..>>>>.>.>>>>>>>.>>>...>>>>..>>>>.>>..<<<<<<<<<<.....>>>>>>>>.>>....>>>>>>.....>>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<......>>>>>>>..<<<<<...<<<..<<<..(((...(((>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<......................<<<.<<<<<<<<<...<<<....<<<..<.<<<..<..<.............>.>.>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.........>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<..<.....................>.......................>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<..........)))...)))...<....>..................>>>>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<.<.<....>>.>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<..<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<...............>>>>><<.<<<<<<<<<<<..<<..........>>.......>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>>.<<<<<.......>>>>>.........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<<..<<...............................................................................................................>>...>>>>>>>>...<<<<<.....<<<<........<<......>>...................<<<<<<<<<<.......>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>><<<<....>>>>>>)))].....<<<<<<<..<<<..)))))).>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<]]].>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.....<<<<<<<.<<..<<<<....<<<........<<<<<.<<<<....>>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>..............>>>>..>>>>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<....<<<<<......>>>>>...>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((...(((((((.((.....)).))).)))).....)))....((((((((((...(((.((((...(....((((((((..({((((......)))))....[[(...).(((....}]])))...).))))))))..))).))))..))))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....(((((((((((..(((((((...((..((....((((.(((...(.(..).).)))))))))..))..))))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((.(..((((......(.((((((())))))).).......))))..))))........))))))..)))))))))))...........[........((((((.((((((.....(.....)..)))))).((((((.((((.(((((((((((.((((..((((..................))))..)))).).))))))).)))...))))..)))).))..((((((((((.....)))))))).))..[.)))))).....))).)))))...)))))...)))))))).<((((........))))((((((....(((((((((((((..(((..(((((........))))..)..)))...((....))...(((((((......)))))))..(((((...(((..(((..[......[[)))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((......................(((.((((((((....(((....(((..(.(((..(..................).))).)..)))..)).)....))))))...(((((((((.(......))))))))))....))))))))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.....{.(((.(.................................(.(........).)..))))...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((..........]]......]]..(.....)......]..........)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...((....(((....)))..........((.((((....(....)...))))))......))....))...(((((........)))))]]((((....(((((...((.((((....)))).))..((((....)))...(...((((((...(((((((((((((((((((((((..{{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....(((((((.......))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((...(([...)...])........)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(..(((.....((((....)))).....))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.(.......((((.((((((..(((((.(((((((((.(((((((..........................................................................................................................)))))))...(((((.....((((.....(..............)................((((((((((.......))))))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a..)..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}}.)))))..)).))...))))...)))).((((...((((.....}.......))))...))))..)))...).)))))).....((((((..((..((((.(..(((........(((((.((((.(.))))).))))).......)))...(((..(((.....((((.(((((((......)))))))))))....)))..)))...........)..))))..)).))))))(((((.(..(.......)..)....((.(((((((.((.....((((.(..(((((......)))))..)))))....))....)))).))).))..))))).. Cryo-EM structure of human EBP1-80S ribosomes (focus on EBP1); 28S rRNA 6z6n L7 120 2.9 RF00001 URS00000F9D45_9606 32687489 0003735 0005840 9606 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. Cryo-EM structure of human EBP1-80S ribosomes (focus on EBP1); 5S rRNA 6z6n L8 156 2.9 RF00002 URS0000005270_9606 32687489 0003735 0005840 9606 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<<<<....>>>>.....<.<<<......>>.............>>>..>...>>>....<<....>><<<<<<<<<.....>>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))(((((((((....).)))))))).................... Cryo-EM structure of human EBP1-80S ribosomes (focus on EBP1); 5.8S rRNA 6z6n S2 1740 2.9 RF01960,RF01959,RF00177 URS00005A14E2_9606 32687489 0003735 0005840 9606 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucgcuccucucccacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgccccccguggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcgggcguccccgcccucucggccggggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggucggcccacggcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<....<<....<<<<<..................<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<<.....>.>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<<......>>>>>>>>.>>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....<<.....<<..<<....>>..>>.......>>......<<..<...........>..>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<.......................<<.<.............>>>...<<<<<<.<.......<<...<.......>.<<<<.......>>>>...>>......>.>>>..>>>........<.<<.<<<.<<<...............>>>.>>>.>>.>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<......>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<.......<<........>>..........<<<<<......<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<.......>>>>.>>>>.....>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.......>>>>>....>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<...<<.....<..>............>>.....>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..((....(((((...((.............((.....((.(((.....))).))......))......)).((((...((((........))))...))))((..(((((...(......)..)))))......)).(.((((.(((.(.....))))))))))).)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).).....(.(((..((.(((....))).))...).).))......((..(...........)..)).........((((([[....(.((((.....((..]])).......))))))))))..)))))).)))..[......(.([[...(.(.((...(((.((.......................((................))...((((((.(.......((..((.......)).(((.......)))....))......).)))..)))........(.((.(.(..((...............))..).).)).)....))...(((..(...(...((((..(((.((((((((...((........))......)))))))).))).......((....))...))))..)...)...))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.((((......)))))))))).)..)))...((..]]))...))...].))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))........(.(((((.(....(((((.....(..((.(((........))).))....).)))))....(.((....(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((...(...((((..((((((((((((.......)))).)))).....))))..))))..).....(((((.....)))))........)))....))).))).....)..)))......).))))))..)).)))).))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....(.(((..(.......)..))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..((((.((...((.((....(...(............)....)......)).))...)).))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}........ Cryo-EM structure of human EBP1-80S ribosomes (focus on EBP1); 18S rRNA 6z6n CC 75 2.9 RF00005 URS0000E60BA3_9606 32687489 0030533 0006412 9606 uccgauauagcguaacggcuaucacaucacgcuuucaccguggagaccgggguucgacuccccguaucggagcca <<<<<<<....<..........>...<<<<<.......>>>>>....<<<<<.......>>>>>>>>>>>>.... (((((((..(.(.....[....).).(((((.......)))))....(((((..]....)))))))))))).... Cryo-EM structure of human EBP1-80S ribosomes (focus on EBP1); tRNA 6z8k H 11 3.02 URS0000868514_2560547 32681014 2560547 aguacacuacu ........... ........... La Crosse virus polymerase at elongation mimicking stage; La Crosse virus 3' vRNA (1-16) 6z8k T 10 3.02 URS00021ED923_2560547 32681014 2560547 aguagugugc .......... .......... La Crosse virus polymerase at elongation mimicking stage; La Crosse virus 5' vRNA 1-10 6z8k P 10 3.02 URS0000868514_2560547 32681014 2560547 guacacuacu .......... .......... La Crosse virus polymerase at elongation mimicking stage; La Crosse virus 3' vRNA (1-16) 6zdu C 65 3.45 URS00021ED938_237561 33856462 237561 ggcaagggcuucccgaauuguggauaguucaauacucgaaaaaauuggaaguaggguauguugcc .<<<.<<<<<<<<........>>>.>>>>>.<<<<<<................>>>>>>..>>>. .(.(.((((.(((........)))..)))).((((((................))))))..)..) Structure of telomerase from Candida albicans in complexe with TWJ fragment of telomeric RNA; Chains: C,D 6zdu D 65 3.45 URS00021ED938_237561 33856462 237561 ggcaagggcuucccgaauuguggauaguucaauacucgaaaaaauuggaaguaggguauguugcc <<<..<<<<<<<<........>>>.>>>>>.<<<<<<................>>>>>>...>>> .(...((((.................)))).((((((................))))))....). Structure of telomerase from Candida albicans in complexe with TWJ fragment of telomeric RNA; Chains: C,D 6zj3 S1 2024 3.15 RF01960,RF01959,RF00177 URS00021ED947_3039 33091122 0003735 0005840 3039 aaucuggnugauccugccagcagucaunugcuuuguunangngcuaagccaugcacnucucagcgcaaacggagugacaguggaucugugaauggcucnuuanaucagcngucaucuacgugauagagugugcucgguccaccugcaaggaccccauuggacauccaccaaaaccuugnngcuaanacacguucgacccagucagccaugcaacacucggcaucaccggugguggcggauguaugcccagcugauacgaagaccagcggccgcaaggccaguguugguugacucaggcuggcccuggccgcagugcugguggauuucgugcaugcgcaugccccacuunaungcaagagcuucugnccuaucagcuugacugugguguaucggaccacaguggccuugacggguaacggagaaucaggguucgauuccggaganggagccugagagacggcuaccacuaccaaggugggcagcaggcacgcnaauugccccaugcaaagacagucugugaggcngcgacgaacaguagcaaccccgucggccuugccgauggggcuuggaauggangcuauccaaagacagccgunagunucanccggagggcaagucuggugccagcagcugcggnaauuccagcuccgagggcgnanacuaacauugcugcuguunaaacacuuguagucugccuacgggcugcaggucugcuggguggccgguuuguuguuucucuggccagcuguguugggcugcaacggcugguacgucccugcgcccaccgauggugaggcuccugccaaaagucugccaaagcgguuuaugccucccgcacuggcaacggacaccaacaggggacccagcagcuggguucugguccaccaccggagcccaccgucugacacccuggaaaanucagugugcucaaagcauccccgcgncggcugaauguccauccauggaaugucaaggcnucgaccaaguguggcauuggaguugugcuggccuuggggcccacucuggacaaccugguggugugcacccaucgaucguaagugaugggacuguucggggugaaagauacgggagcgccagaggugaaauucuuagaucgcugccagauccacugcagcgaaggcguucugcaagugcacguccgucgaucaaganugagaguucggggagcaaagaugaucagacaccgucguaguccggccacuguaaacgaugccggccaggccuuggcagagcaagaauccuagacucugucagggccaacgagaaauccacagccuguggguucaggggggaguacugucgcaangcugaaacuuaanggaauugacggaauggcaccacaaggcguggaguaugcggcuuaauungacncaacgcggggaaugnuaccaggunaggacgcaacuggganugacagauugagagcucuuucuugaucuuguggacggngnugcauggccgcuccugauuggugnagugauuugucugguugauuccgauaacgagugagacancugccucccacuagccugaggcucgcuagggggcugcugcaugcucccgagagccuccaguucagcuucucugaggugcuguguccgccacaaagggcaugcaugcunnagccaacagcaggucugugaugcucccagauguccugggccgcacgcgcacuacauugucacagngaaggugucgacaugcccacgugggcccuggccugaagaggcugggaaauccugcaagccugugacguacnggggnuagaugguugcaacugucugccuugaacnugnaaugccuaguaugccugggucaucagcccagaccgauuguguccnugccauuuguacacaccgncngucguugcuaccgaugguggcuggauagagucaucnggagguuguggagggcaucccagccgaaauuggacgauguccagccacuagaggaagcaaaagucguaacaagguugcuguaggugnnccugcagcaggaucauu ...<<<<<...[[[[>>>>>.<<<.<<<<<<..<<<<<..<......<<<.<<<..<<....<.....<<.........>>....>.>>......<<..<....<<<<.<<<..<<<..<<<<<.......((..<<<<.....))...>>>>....<<.....<<<<.<.....>.>>>>......>>...........<<<.<<<<<....<<<.<<.......>>>>>>>>>>.>>>..<<..<<<<<<......[[[.(((((<<<<....>>>>................>>>>>><<..>>.....>>....<<<<.......<<<<<..>>>>>.>>>>...>>>>>.>>>>>>.>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>...<<<<<<<<....>>>>...>>>>>>>.<<.<<<..........>>>.>>.<<<<<..>>>>>...>>>>>>.........<<<....<<<.........>>>..>>>..>...>>>>>....<<<.<<<<<<<<<...>>>>>>>.>>.>>>......<<<<............>>.>>..........<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>...>>>>>>>>>..........<<<{{.....<.<<...<<<.<.....<<<<.<<<<<.<<.........<<<...<<<<<<..<.<..<<<<..>>.>>.>.>..>>>>>>..>>>.>.>..>>>>>>>>>...<<<<<<<..<<<<<.<<.....<.....>.....>.>.......<<.......>>....<<<<......<<<...<<..<<.>>.>>..>>>.>>>>......>>>>>.>>>>>>>.<<<<<<.<<<<.....<<..<<.......>>..<<.......>>.....>>....>>>>.>>..>>>>.......<<.<<<<<<<.<<<...........))))).]]]...>>>>>>>.>>>......<<<<<<.<<..>>>>>>>>..>>....>....<<<.<<<.<...<<<.<<<<..<<<.<<<<...<<<......>>>......>>>>.>>.>.>>.......<<....>>.>>.>>>..>.>>>..>>>...>>>...>>.>...<<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>..>>>.........<<<.<<..<<<<<<<<<<<<<..<......>...>>>>>>>>>>>>>...<<..}}>>....>>.....>>>.>>>.<<<.......<<<....>>>.....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<.....<..<<.<<<........>>>.>>.>....>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>......<<<<<<<<.....<<<<<<<<<<<<....<<<<<<<<<.>>>.>>>>>>..>>>>>>.>>>....>>>.....>>>>>...<<<<<<........>>>>>>.......>>>......>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<<.......<.......<<<<<..>>>>><<<<<<<<....>>>>>>>>....>........>>>>>>>...........<<.<<<..........>>>.>>..........>>>>>>.....<.<<<<<.......>>>>>.>.......>>...>>>>>>>>>>.>>....<..<<.<.<<<<<.<<...<<<<<<<<<<<<..<<<.......<<<<<.<<<.....>>>>>>>>.......>>>..>>>>>>>>>>>>...>>.>>>>>..>.>>...>.....<<<<<<<<<<..>>>>>>>>>>........ ...((((....[[[..)))).(((.(.((((..(((((..((.....(((.(((...(....(.....((.........))....).).......(((.......(((.(((..(((..(.(((...(.{.[[..(((((....]]..))))))...((.....((((.........))))......))...........(((.(((((....(((..((.....)).)))))))).)))..((..((((((......[[[.[[[[[((((....)))).......(......).))))))((..))}....))....((((.......(((((()))))).))))...))).).)))))).))).(((....(((..((((((((.......)))))))))))......)))...(((.(((......)))....)))))).((.(((..........))).)).((((....))))...)))))).).....(.(((....(((.........)))..)))).)...)))))....(((.(((.(((((...))))).).)).)))....(..(((............)).).......)...(((([[....(.((((.....((..]])).......)))))))))...)))).))))...{......((({{...(.(.((...(((..(....((((.(((((.((.........((.(...((((...(.(..((((())).))..))...))))..).)).).)..)))))))))...(((((((..(((((..((....(.(.).).....))........((.......))....((((......(((...((..((.)).))..))).))))......))))).))))))).((((((.((((.....((..((.......))..((.......)).....))....)))).))..)))).......((.(((((((.(((...........]]]]].]]]...))))))).))).......((((..((())).))))...))...)....((((.(((.(...(((.((((...((.((((...((........))......)))).))...)).......((....)).)).)))..).)))..)))..))))...)).)....(.((((...((...((.(.........).))...))))))...)......<...(((.((..(((((((((((((.............)))))))))))))...((..}}))....))...}.))))))).(((.......(((....))).....)))...]]]..((((..(.(((((..((..(((.(..(((.((((((......((........))........(.(((((.(....(((((.....(..((.(((......[.)))]))....).)))))...((.(((...(.((((((....(((.((((......))..(.((......)))...)).)))......(((.((((..(..((((((((((((....(((((((((.))).))))))..)))))).)))....)))..)..))))..(.((((((........))))))....)..)))......))).))).....).))))).....).))))))..)).)))).))).(...(.(((((.......(.......(((((..)))))(((.((((....)))).)))....)........))))).)......(....((.(.(..........).).))....)..)..).)))......(.(((((.......))))).).......))...))))).).)).))..(.(..((.(.(((((.((..(((((((((((((..(((.......(((((.((((..).)))))))).......)))..)))))))))))))..)).)))))..).))...)..)..(((((((((....)))))))))>....... Cryo-EM structure of the highly atypical cytoplasmic ribosome of Euglena gracilis; 18S rRNA 6zj3 S2 76 3.15 RF00005 URS000080E264_3039 33091122 0030533 0006412 3039 gcgcggauagcucagucgguagagcaggggauugaanauccccguguccuugguucgauuccgaguccgcgcacca ..<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>...... .(.(((...((((........)))).(((((.......)))))......(.((.......)).)..))).)..... Cryo-EM structure of the highly atypical cytoplasmic ribosome of Euglena gracilis; A-tRNA 6zj3 S3 76 3.15 RF00005 URS00021ED908_3039 33091122 0030533 0006412 3039 gcgcggauagcucagucgguagagcaggggauucauaauccccguguccuugguucgauuccgaguccgcgcacca <<<<<<<..<<<<........>>>><<<<<<<.....>>>>>>.>...<<<...........>>>>>>>>>>.... (((((((..((((........)))).(((((.......)))))........(........)....))))))).... Cryo-EM structure of the highly atypical cytoplasmic ribosome of Euglena gracilis; P-tRNA 6zj3 S4 76 3.15 RF00005 URS00021ED9CB_3039 33091122 0030533 0006412 3039 gcgcggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgcgcacaa <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((.(........).)).(((((.......))))).....((.((.......)).))))))))).... Cryo-EM structure of the highly atypical cytoplasmic ribosome of Euglena gracilis; E-tRNA 6zj3 S5 12 3.15 URS00021ED951_3039 33091122 3039 caccauguucaa ............ ............ Cryo-EM structure of the highly atypical cytoplasmic ribosome of Euglena gracilis; A-site tRNA 6zj3 LA 160 3.15 RF00002 URS000052BC46_3039 33091122 0003735 0005840 3039 accuguugugguggaugucuuggcccagguucugaggangnacacagcagccuugcgauacguucggugauacncagaucuugugaucuggacaanggaacagcuucgaacgcaacuggccagcaagggguccccccgagcugccugugcgccaguguug .......................................<<<..<.((......>.........<<<......))............>>>..............>>>....<<.....>>.<<<..<<<<...>>>>..>>>.................. .......................................((((.(.[[......).).......(((......]]............)))..............)))....((.....)).(((..((((...))))..))).................. Cryo-EM structure of the highly atypical cytoplasmic ribosome of Euglena gracilis; 5.8S rRNA 6zj3 LB 133 3.15 RF02543 URS00000C91D7_3039 33091122 0003735 0005840 3039 gugaccuggcgcacaugganugacccaccgaacuuaagcauancacucagungaggaacagcaagcaaccucgauugcugcagnaauggcgaaugaacgagcaggacccacggcucuuccugaaaaugggcuu .......................<<<<<......<......>.......>>>>.>.........<......>..<<<<<......<<.....>>.....>>>>>............................. .......................(((((......(...[..).......)))).).........(......)...((((......((.]...)).....)))).....(...).................... Cryo-EM structure of the highly atypical cytoplasmic ribosome of Euglena gracilis; LSU rRNA chain 1 6zj3 LC 350 3.15 RF02543,RF02540 URS00021ED937_3039 33091122 0003735 0005840 3039 cucgaucggcuuucguuggaauccagcaaacccugugggcuauggagcaguuggcugugucucggugcuucccaguaccaagaagaguccuggaauggacccacgaaacagggagacugucccguauggcugaaccgugugcugggaucacugggauguggcuggcuguauccccgaguagaguggnuugggacngcaguuugaagagugacguguauccgucacaagguggcauacagancugngaccgauagugcacaaguagagugaucgaaggaugnaaagaacuccgcgaagnggguuaaaagucccugaagccgcaacaggaucgnugnugugcagugcuguau <.<<<.......>>>..>.........................<<<<<<<<<<<<<....<<<<<<...<<<<<<<<<........<<<<......>>>>..((......<<<.....))>>>...............>>>>>>>>>..>>>>>>....>>>>>>>>>>.>>>.......<<<<.<<........>>.>>>>.....<<<<<........>>>>>.......................................<<....>>...............<<<......>>>................................................... (.(((.......)))..).........................((((((((((((((...(.((((...((((((.((.(......((((......))))..[[(...).(((.....]])))...)...........)).))))))..)))).)...))))))))))).)))........((..((........))..))......(((((........))))).......................................(......)............(..(((......)))...........)....................................... Cryo-EM structure of the highly atypical cytoplasmic ribosome of Euglena gracilis; LSU rRNA chain 2 6zj3 LD 110 3.15 URS000020DCE1_3039 33091122 3039 accaagcgucucugggucagcccagggcuggccaccgagccccugucuccggacagggaugacuaucguggcagccccugguggcagcuccgccugccaggaccuggagu .........<<<<<<<<<.<<<<<<<<<<.<<<<<.<...<<<<<<<....>>>>>>>........>>>>>>>>>>>.>>>..........>>.......>>>>>>>>>. .........(((((((((.((((((((((.(((((.((.((((((((....)))))))..)....)))))))))))).)))..........)).......))))))))). Cryo-EM structure of the highly atypical cytoplasmic ribosome of Euglena gracilis; LSU rRNA chain 3 6zj3 LE 652 3.15 RF02543,RF02540 URS0000525397_3039 33091122 0003735 0005840 3039 ucgcuggugguugggcuggggggugugcggcugcaccgggggcugcaccguacggugguccccuugcuggcugcaccgucccccagccugaccccagugagaaauuggcagcagagcuuggcacgcagugcugcucucugcccgucucgnaacnngnaccaaggagunuaaggagcuugccagucggauggcuuccaaaaccuugaggcguggugaaggcaacuauccuuccagauggggcuagucucugcnuggaacgaccggacccgaaguccaguggacaggguuucgagngcuugcaagguccuugggacccnanagguggugaacuaunccguucuacggugaagccaugggaaacugugguggaagccggungcuguucugacgugcaaaungugnagccugagugcngcnuagnggugaaagnncaancgagccaccuaguagcugguucccuucgaaguuucccucaggauagcngggauccaaugaugcaaagugugacugguugcaucnggnaaagcaacncaugagaggcuggggagcuccucaaccuauccucgaacugugaaugggugcggacaggcaugcuucuuugccacgacaggaggcuguguaacagcaguucuccccgucuucngagcauguu <<<<<<<.<<<<<<<<<<<<<<<<<<<<<<<<<....<<<<<...<<<<<..>>>>>.>>>>>....>>>>>>>>>.>>>>>>>>>>>>>>>>>>>>>>>..........<<.............................<<<<........>>>>.........<<<<<<<<.<<<<<..<<<....<<.........>>....>>>...<<....>>........<<<<<...<<<<....>>>>....>>>>>..<<<<<<<<<...<<<<...>>>>.>>>>.>>>.>>....>>>>>.>>>>>>>>.<<.<..<<<<<<<.....<<.<<<<.<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<.....<<........>>....>>>....>.>>>>.>>...<<<.....>>>......>>>>>>...>..>.>>............<.<<<....>>>.>................>>...............<<<<<<<...<<<...<<.<.<<.<<<.<<<<<<..>>>>>>.>>>.>>.>>>..>>.>...>>>>>>>.....<<<<<<<<.<........<<<.<<<<.<<<<......>>>>..>>>>..>>>....>>>>>>>>> (((((((.((((((((((((((((((((.(((.....((((....(((((())))))..)))).....))).)))).)))))))))))))))))))))))..........((.............................((((........))))..........(((((((.(((((..(((....((.........))....)))...((....))........(((((...(((......)))....)))))(.(((((((((...((((...)))).)))).))).)))...))))).)))))))..((.(...((((((.....((.((((.((.(((....(((((((....))))))).....)))...(((...(.(..........))...)))..).).)))).)).(.(((.....)))...)..))))))......).))............(.(((....))).)................))...............((((((....(((...((.(.(...((.((((((())))))).))...).)))..)).)....)))))).....((((((((.(......(.(((.((((.((((......))))..))))..))).)..))))))))) Cryo-EM structure of the highly atypical cytoplasmic ribosome of Euglena gracilis; LSU rRNA chain 4 6zj3 LF 456 3.15 RF02543,RF02540 URS00021ED9C9_3039 33091122 0003735 0005840 3039 uugaacaauggauccuacguggaccaugacugguaagcngngcuggugaugcggggugcuccgagagcagacuuacagaucccgagugcnggcucauacucagaucccanaaaggauguugcuuacuaguncgcancuccgaaaauggangnugcccaagucagugugucucccuuacagucugccaucgauguggcagccaaggcngagcaucguuguguagaaagggcauggacaacagcugaucguguugggauugaucccggcuugaggcguugcccagngcanaunungnunguaguanngaguacuccaccuggagagnaguggcaacacaaccccgcugugugcnguugnggncuggagnggagcagguuuccacaccaaacagncguugnaugugggucaaccgaccgugagccaanngguaaguucaccgaacaancaaagcugccu ......................<<<<..<<<<.....>>>>..>>>>....<<<......>>>...<<<<<<<...<<..((.....<<<<<<.........<..........<<<.<<<<<.<<<..>>>.>>>>>>>>..........))..>....>>>>>>........>>...>>>>>>><<.<<<<<<...............>>>>>>.>>.............<<<.<<<<.<<.......<<<<<<<....>>>>>>>.....>>>>>>.>>>............................<<<.<<<.........<<<<..........>>>>.......>>>.>>>....................<<<<<.....<<.....>>..>>>>>....................<<<.......>>>................... ......................((((..((((.....))))..))))....(((......)))...(((((((...((..[[.....((((.(.........(..........(((.(.(((.(((..))).))).))))..........]]..)....).))))........))...)))))))((.((((((...............)))))).))...........(.(((.((((.((.......(((((((....))))))).....)))))).)))..).........................(((.(((.........(.((..........)).).......))).)))....................(((((.....((.....))..)))))....................(((.......)))................... Cryo-EM structure of the highly atypical cytoplasmic ribosome of Euglena gracilis; LSU rRNA chain 5 6zj3 LG 207 3.15 URS00021ED913_3039 33091122 3039 ggcaggaanggcaancagncaagugcgagcangauucuacugucaugggcuggucgguggcgacacccccuccaggcaucgaaccagugaauccccuguggaguucucguuuccnccugaugcagacucacncgggcuaucgaucggcaugacagauggugguguaugcccuucgcucagcaaggcgguguggucucacaccgaugg .....................<<<<............>>>>..............<<<<....>>>>...........................<<.<.<<<<.......>>>>.><...<<.<<........<<<<<<<.......<<<.....>>>.....>>>.>>>>....>>>>....>.<<<<<<<....>>>>>>>..>> .....................(((..(.........).)))..............((((....))))...........................((((.(((.........))).)(...((.((......(.((((((........(.(.....).)......)).))))..).))))....).(((((((....)))))))).)) Cryo-EM structure of the highly atypical cytoplasmic ribosome of Euglena gracilis; LSU rRNA chain 6 6zj3 LH 559 3.15 RF02543,RF02540 URS000048FDFB_3039 33091122 0003735 0005840 3039 aaguggcagucacugguuncaaugaacagccugaaggauuccccuuguguccguacugcaucaccgcagccggucuncucgacuagacgucgcuuguccacggacgaaangnngcuaagggnagucggcaaacuggccgugcaccuuuggaagauacgguggcuccagaggccauggcucguguggaacuguugnugngcagnggaaucugacuguunaauugaaaccnagcuuugugaagggaccagcuggcugguuccgugaggugacuucugccnagugcucugauugucaaugcgangaganucagccaagcgcggguaaacggcgggaguancuaugacucucuuaagguagcnannugccucnucaaccaauuauugacgcgcaugaauggancancgngnuuccugcugunccuagungcngucuggugaaccancaancaagggaacgggcuugnaugugucancggngaangaagacccunuugagunugacncuaguuugauncuguncaacaacauguggggcguagcauaggugggaggugagugcc ...............................................................<<......>>......<<<<.....>>>>........<<<<......<<.<<<<.<<.........<.....<<<<<<.............>>>>>><<.<<<<..<<<<..>>>>....>>>>.>>............<<<<<<<<<...<<.........>>...<<<<<<<....<<.<.....>.>>......>>>>>>>...<<..<<<..<<<<<<....<<<....<<<<<....>>>.>>...>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>.>>..>>>>............<<<<<........>>>>>................................................................................................ ...................(...).......................................((......))......((((.....))))........(((.......((.((((.((..(....(.......(((((....(.[..).....)))))((.(((....(((())))......))).))(...).......(((((((.(...(...........)...((((.((....((.(.....).))......)).)))).].(.(.(((..((((((.....((....(((((....))).))...))..))))..)))))(.(.(.........).).)........((..........(((((.......)))))..)..)....).)....)..))))))).)..))).)))).))...))).........[..(((((......].)))))................................................................................................ Cryo-EM structure of the highly atypical cytoplasmic ribosome of Euglena gracilis; LSU rRNA chain 7 6zj3 LI 573 3.15 RF02543,RF02540 URS00021ED939_3039 33091122 0003735 0005840 3039 ggugcgagccugcagugaaauaccacuaccuucaccguuguuuuacucaucgaguugcaagagagcgguggccaugcuuuccccgauucaugcaccaagucugcagcagcuguuguggacgacucacgugucacaguccgaucagucncgaaacaucgancaguuggggaguuugncugnggcggcacgccuuuuanaacacnacgaaggnnuccugaagcauugcucaggcagaacagaaaucucccagggaggagaaggccaaaggugcugcugaugcugcgacucncaguacgaguccganacgugcaaucguggccuaacgauccuuuggunnagugugngaauucuggaunucgaagncanangugucagaaaaauuaccacagngauaacuggcuuguggcugccaagcguucaaancgacgucgcuuuuugauccuungaugucggnucuuccuagcuucccacccgcagccgaguggaagnguungaunnuucacccancancagggaacgugngnugggnuuagancgucgugagacagguugguuuuacccuccugccacaga .................................................<<<<<......<<<..<<<.<<.........>>>>>.............<<<<<<<<<<..>>>>>>>>>>..>>>...<......>..........>>>>>........................<<<.....>>>..<<<<<<...........>>>>>>..<<....<<<.<<<...<<.<<<.......>>>.>>.....<<...(((>>....>>>.>>>.........<<<<<.......>>>>>.....<<......>>.>>))).......<<<<<<<............<<<........>>>>>>>>>>.............................<<.<...<<<.<<...<<.......>>...>>.>>>....>.>.>.......<<<<<.<<<<<<..<<<<<.<<.<......>.>>>>..>>>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>...................... .................................................(((((......(((..(((.((.........))))).............((((((((((()))))))))))..)))..(.........)........))))).......................(((......[)).)((((.(..........]).))))([((....(((.(((.(.((.(((.......))).))...).((]...[[))....))).))).........(((((....{..))))).....((......)).))]]........(((((((............(((........))))))))))....)}.......................(....(..((..(...((.......))...)..))....)....)........((((.((((((..(((((.((.(......).))))..)))..((.(.....).))......)))))..)...))).)......((((((....))).)))....................... Cryo-EM structure of the highly atypical cytoplasmic ribosome of Euglena gracilis; LSU rRNA chain 8 6zj3 LJ 163 3.15 RF02543 URS000028D25E_3039 33091122 0003735 0005840 3039 gggcgugacaauggcaucacaugguaguacgagaggaacccuuguggcacnccccugguuuccaccgugagucgagcgacugguguagugaagcuaccaagunacgganacugacuggacgcaucuuaagccngaauccgagaccaggccuacagcaugccug <<<<<<<....<<<..<<<<<.<<...............>>.>>>>><<<<....<<<<....<<.<<.<<<<....>>>>...>>.>>...>>>>...>>>>.<<<<....<.<<............>>.>....>>>>...>>>.........>>>>>>>. (((((.(.(..(((...((((.((.....(....)....)).)))).((((....(.(.....((.((.((((....))))...)).))....).)...)))).((((....(.(..............).)....))))...))).).......).))))). Cryo-EM structure of the highly atypical cytoplasmic ribosome of Euglena gracilis; LSU rRNA chain 9 6zj3 LK 61 3.15 URS00001F2189_3039 33091122 3039 agcaucgaggcagagcaguacccuucgggucugcgccaacaccaacuggaucugaacuggc ...<<.........<<<<.<<<.....>>>>>>>...............>>.......... .(.((.........((((.((((...))))))))...............)))......... Cryo-EM structure of the highly atypical cytoplasmic ribosome of Euglena gracilis; LSU rRNA chain 10 6zj3 LL 92 3.15 URS00021ED997_3039 33091122 3039 cggagugauugccggcaccggauguggugugcaggccugcgagauggcauugagugggcaggcugcaagccuccugccggucggacaaacng .<<<<...<<<<..<<<<..........>>>>..<<<<<<..<<<<.>>>>..>>>>>>.....>>>>..>>>>.................. .((((...(((((.(((((......)..))))..((((((..(.((.)).)..))))))..)..))))..)))).................. Cryo-EM structure of the highly atypical cytoplasmic ribosome of Euglena gracilis; LSU rRNA chain 11 6zj3 LM 54 3.15 URS000000B469_3039 33091122 3039 caacaccccgcccagaccaggcuggaucugcggcgaguguaagugnagagguua .........<<<.......>>>................................ ........((((.......))).).............................. Cryo-EM structure of the highly atypical cytoplasmic ribosome of Euglena gracilis; LSU rRNA chain 12 6zj3 LN 79 3.15 URS00005085D6_3039 33091122 3039 guccgauccguugagcuccaaggccgggcuucugcagggaguggcgcugccccugcuggggccgacgacagagugggug ..........................<<<<<<.<<<<<<..<<<..>>>.>>>>>>.>>>>>>................ ..........................((((((.((((((.((((())))))))))).))))))................ Cryo-EM structure of the highly atypical cytoplasmic ribosome of Euglena gracilis; LSU rRNA chain 13 6zj3 LO 120 3.15 RF00001 URS0000EFFB5F_3039 33091122 0003735 0005840 3039 gcguacggccauacuaccgggaauacaccugaacccguucgauuucagaaguuaagccuggucaggcccaguuaguacugaggugggcgaccacuugggaacacugggugcuguacgcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<<<<..<<....>>.>>>>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......(((((..((....)).))))).....))))))))))))))).. Cryo-EM structure of the highly atypical cytoplasmic ribosome of Euglena gracilis; 5S rRNA 6zlc C 19 2.3 URS00021ED96C_32630 32867106 32630 agacagcauuaugcugucu ................... ................... Non-specific dsRNA recognition by wildtype H7N1 RNA-binding domain; RNA (5'-R(*AP*GP*AP*CP*AP*GP*CP*AP*UP*UP*AP*UP*GP*CP*UP*GP*UP*CP*U)-3') 6zlc D 19 2.3 URS00021ED96C_32630 32867106 32630 agacagcauuaugcugucu ................... ................... Non-specific dsRNA recognition by wildtype H7N1 RNA-binding domain; RNA (5'-R(*AP*GP*AP*CP*AP*GP*CP*AP*UP*UP*AP*UP*GP*CP*UP*GP*UP*CP*U)-3') 6zm5 A 1534 2.89 RF02541,RF02540 URS00021ED93A_9606 33602856 0003735 0005840 9606 gcuaaaccuagccccaaacccacuccaccuuacuaccagacaaccuuagccaaaccauuuacccaaauaaaguauaggcgauagaaauugaaaccuggcgcaauagauauaguaccgcaagggaaagaugaaaaauuauaaccaagcauaauauagcaaggacuaaccccuauaccuucugcauaaugaauuaacuagaaauaacuuugcaaggagagccaaagcuaagacccccgaaaccagacgagcuaccuaagaacagcuaaaagagcacacccgucuauguagcaaaauagugggaagauuuauagguagaggcgacaaaccuaccgagccuggugauagcugguuguccaagauagaaucuuaguucaacuuuaaauuugcccacagaacccucuaaauccccuuguaaauuuaacuguuaguccaaagaggaacagcucuuuggacacuaggaaaaaaccuuguagagagaguaaaaaauuuaacacccauaguaggccuaaaagcagccaccaauuaagaaagcguucaagcucaacacccacuaccuaaaaaaucccaaacauauaacugaacuccucacacccaauuggaccaaucuaucacccuauagaagaacuaauguuaguauaaguaacaugaaaacauucuccuccgcauaagccugcgucagauuaaaacacugaacugacaauuaacagcccaauaucuacaaucaaccaacaagucauuauuacccucacugucaacccaacacaggcaugcucauaaggaaagguuaaaaaaaguaaaaggaacucggcaaaucuuaccccgccuguuuaccaaaaacaucaccucuagcaucaccaguauuagaggcaccgccugcccagugacacauguuuaacggccgcgguacccuaaccgugcaaagguagcauaaucacuuguuccuuaaauagggaccuguaugaauggcuccacgaggguucagcugucucuuacuuuuaaccagugaaauugaccugcccgugaagaggcgggcauaacacagcaagacgagaagacccuauggagcuuuaauuuauuaaugcaaacaguaccaaaccugcauuaaaaauuucgguuggggcgaccucggagcagaacccaaccuccgagcaguacaugcuaagacuucaccagucaaagcgaacuacuauacucaauugauccaauaacuugaccaacggaacaaguuacccuagggauaacagcgcaauccuauucuagaguccauaucaacaauaggguuuacgaccucgauguuggaucaggacaucccgauggugcagccgcuauuaaagguucguuuguucaacgauuaaaguccuacgugaucugaguucagaccggaguaauccaggucgguuucuaucuacuuucaaauuccucccuguacgaaaggacaagagaaauaaggccuacuucacaaagcgccuucccccguaaaugauaucaucucaacuuaguauuauacccacacccacccaagaacaggguuugu <<<.......<<<<.....................................<......>.........<.....<<.....>>....>........>>.>>.............<<....>>......................>>>...........<<<.......>>>...<.<........>.>.<<<<<<.........<<<.<<..<<....>>...>>.>>>...<<.<..<<<<<.<.....<<<<<.<<<..<<<.....>>>...<<<..<<<<........>>>>.>>>....>>>.>>>>>...<<.......>>......>.>>>>...>..>.>>..<<<<<<....<<<<....>>>><<<.<<<<<<<<<<.....<<..........>>.....>>>>>>>>>>..>>>.<<<<<<<<<<......>>>>>>>>>>.<.<<<......>>>.>..<<<.<<<...<..............<....<<<.........>>>....>.......<<<......>>>....................................>...>>>>>>........>>>>>>...<<<<<......>>>>>.........>>>>>><......<<..<<<....>>><<<...<<<<........<<<<<.<<........>>.>>>>>......<<<...<<<<.......................>>>>.......>>>.....<<......>>.>>>>......>>>..<<<<...<<<<<<<<.<<.........<......<<<<<<..<<<.........>>>...<<<<<<.............>>>>>>....<<<.<<<..<<<<<....>>>..>>>>><<<<<<......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>....>>.>>>>.....>..>>.>>>>>>>>>>>>.>>.....>.....<<<<<........>>>>>.......<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<....<..>......>>>>>>>>>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<.....<<<..<<<<.....>>>>..>>>...........>>.........<<<....>>>............>>>>..>>>>>>.......<<<..<.<<<<<<...<<.......>>...>>>>>>...>.>>.>.......<<<<<.<<<<<<..<<.<<<<<<......>>>>>>...>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>...<.<<<.<<<.................>>>.>>><<<<<...<<<....>>>.>>>>>......<<<................>>>......>..........<<<<.......>>>>.... ((.....(..((((.....................................(...[..).........(.....((.]...))....)........)).)).............((....))....)..................)).........(.(((.......))).[.(.(........).).((((((..(......(((.((..((....))...)).)))...((.(...((((.(.....(((((.((((.(((....[)))...(((..((((.......{)))).)))..).))).))))).(.((.......))...)..).))))......).))).((((((....((((....)))).((.((((((((((.....((..........)).....))))))))))..))..((((((((((......))))))))))...(((......)))....(((.(((...(..............(.(..(((.........)))..).)....(..(((......))))...................................)...))))))........))))))...(((((......))))).........))))))(......((..(((....)))(((...((((......(.(((((.((........)).)))))......(((...((((...............(..)....)))).......))).)...((......)).))))......)))..((((....(((((((.((..(....(........((((((.].((.........))....((((((.............))))))....(((.(((..(((((....)))..)))))(((((........)))))........((..........(((((.......)))))..)..)....)))....)).))))....)..))).))))))).)))).)).....)).{..(((((.....]}.))))).......((..(((.((......((((.((((((..(((((.((((((((....(())......)))))))))))))..(((......[)))((((((..........]))))))(.((.....((...(((....[..)))...))...........)).........(((....))).....)].....))))..))))))......((((..(.((((((.(.((.......)))..))))))...).)).).)......((((.((((((..((.((((((......))))))...)).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..}.))..))).))...(.(((.(((......(....).....))).)))(((((...(((....))).)))))......(((................)))......).........(((((.......))))..). Human mitochondrial ribosome in complex with OXA1L, mRNA, A/A tRNA, P/P tRNA and nascent polypeptide; 16S mitochondrial rRNA 6zm5 AA 954 2.89 RF00177 URS00008F947B_9606 33602856 0003735 0005840 9606 auagguuugguccuagccuuucuauuagcucuuaguaagauuacacaugcaagcauccccguuccagugaguucacccucuaaaucaccacgaucaaaagggacaagcaucaagcacgcagcaaugcagcucaaaacgcuuagccuagccacacccccacgggaaacagcagugauuaaccuuuagcaauaaacgaaaguuuaacuaagcuauacuaaccccaggguuggucaauuucgugccagccaccgcggucacacgauuaacccaagucaauagaagccggcguaaagaguguuuuagaucacccccuccccaauaaagcuaaaacucaccugaguuguaaaaaacuccaguugacacaaaauagacuacgaaaguggcuuuaacauaucugaacacacaauagcuaagacccaaacugggauuagauaccccacuaugcuuagcccuaaaccucaacaguuaaaucaacaaaacugcucgccagaacacuacgagccacagcuuaaaacucaaaggaccuggcggugcuucauaucccucuagaggagccuguucuguaaucgauaaaccccgaucaaccucaccaccucuugcucagccuauauaccgccaucuucagcaaacccugaugaaggcuacaaaguaagcgcaaguacccacguaaagacguuaggucaagguguagcccaugagguggcaagaaaugggcuacauuuucuaccccagaaaacuacgauagcccuuaugaaacuuaagggucgaagguggauuuagcaguaaacugagaguagagugcuuaguugaacagggcccugaagcgcguacacaccgcccgucacccuccucaaguauacuucaaaggacauuuaacuaaaaccccuacgcauuuauauagaggagacaagucguaacaugguaaguguacuggaaagugcacuuggacgaacc ..((((..<<<<<<.)))).<<<<<<.<<..<<<<<<<<....<<<.<<<..<......>......<<.......<<<<.<..<<<.....>>>.>..>>>>..<<<<....<<...<<<....>>>..>>......>>>>.<<...>>.>>.<<<....>>>.....>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>.....<<<<<<<<.....(((.....((.>>>)).......)))..>>>>>..>>.>>>>>>....<<<((.....<<<<..<<<<...............<<<<<<......<<<.<<<.<<<......>>>..>>>.>>>.............<<....>>.>>>>>>.....>>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<.<<<<.......))...>>>>.>.>>>.<<.......<<<<....>>>>.....>>..>>>>>><<<<<.<<<<<<<...<<<.<<<<<..<<<<<<<<<<.....<<........>>..........<<<<<<<.......<<.<<<..<<<<<<.......<<..<<<<<.....>>>.......>>..>>.....<<<....>>>.........>>>...>>>>>>>>....>>>>>>>..>>.>>>>>>>>.....<<<<.....>>>>.....<....<<<<<<<.......>>>>>>>....>.....>>>>>.....<<<<<<<.........>>>>>>>.....>>>...>>>>>>>>>>.>>....<..<<.<...<<<<<<..<<<<<......<<<....<<.....>>...>>>.......>>>>>.>>>>>>....>.>>...>.....<<<<<<<<<....>>>>>>>>>......... [.[[[[..(((((..]]]]]((((((.((..((((((((..(.(((.(((..(......)......(((......((((.(..(((.....))).)..))))..((((....((..((((....))).)))......)))).((...))))).(((....))).....)))))))......(.(((...(((((....)))).))))).)).)))))).....((((([[[.....(((.....((.]]])).......)))..)))))..)).))))))....((([[...(.((((...(((...............(((((((.....(((.(((.((........))..))).))).....).....(.((....))))))))).....)))....))))....((((((...((...((((.........))))...))))))))......{...(.(((((......]]..))))).))))).((.......((((....)))).....))...)))))(((((.(((((((...(((.(((((..((((((((((.....((........))..........(((((((.......((.(((...((((((.(....((..(((((.....))).......))..)).....(((....))).....).).)))...)).)))))....)))))))..)).)))))))).(...((((.....)))).....(....(((((((.......)))))))....)..)..))))).....(((((((.........))))))).....)))...)))))))))).))..(.(..((.(...((((((...((((..((..(((....((.....))...)))..).)..))))..))))))....).))...)..)..(((((((((....)))))))))}........ Human mitochondrial ribosome in complex with OXA1L, mRNA, A/A tRNA, P/P tRNA and nascent polypeptide; 12S mitochondrial rRNA 6zm5 w 68 2.89 RF00005 URS00021D59F7_9606 33602856 0030533 9606 ugguauauaguuuaaacaaaacgaaugauuucgacucauuaaauuaugauaaucauauuuaccaacca <<<<<....<<<<.....>>>>.<<<<<.......>>>>>....<<<<<...>>>>>..>>>>>.... (((((.(..(((.......))).(((((.......)))))....(((((...)))))).))))).... Human mitochondrial ribosome in complex with OXA1L, mRNA, A/A tRNA, P/P tRNA and nascent polypeptide; A-site tRNA with aminoacylation 6zm5 x 70 2.89 RF00005 URS00021ED990_9606 33602856 0030533 0006412 9606 uagggaauaguuuaaaaaacagcugacuuucaaucagcagauggagguucaauuccuccuucccuaacca <<<<<<<..<<<<...>>>>.<<<<<.......>>>>>....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...)))).(((((.......)))))....(((((.......)))))))))))).... Human mitochondrial ribosome in complex with OXA1L, mRNA, A/A tRNA, P/P tRNA and nascent polypeptide; P-site tRNA 6zm5 y 19 2.89 33602856 9606 uuuaagaacguguuuauuu ................... ................... Human mitochondrial ribosome in complex with OXA1L, mRNA, A/A tRNA, P/P tRNA and nascent polypeptide; mRNA 6zm6 A 1531 2.59 RF02541,RF02540 URS00021ED93A_9606 33602856 0003735 0005840 9606 gcuaaaccuagccccaaacccacuccaccuuacuaccagacaaccuuagccaaaccauuuacccaaauaaaguauaggcgauagaaauugaaaccuggcgcaauagauauaguaccgcaagggaaagaugaaaaauuauaaccaagcauaauauagcaaggacuaaccccuauaccuucugcauaaugaauuaacuagaaauaacuuugcaaggagagccaaagcuaagacccccgaaaccagacgagcuaccuaagaacagcuaaaagagcacacccgucuauguagcaaaauagugggaagauuuauagguagaggcgacaaaccuaccgagccuggugauagcugguuguccaagauagaaucuuaguucaacuuuaaauuugcccacagaacccucuaaauccccuuguaaauuuaacuguuaguccaaagaggaacagcucuuuggacacuaggaaaaaaccuuguagagagaguaaaaaauuuaacacccauaguaggccuaaaagcagccaccaauuaagaaagcguucaagcucaacacccacuaccuaaaaaaucccaaacauauaacugaacuccucacacccaauuggaccaaucuaucacccuauagaagaacuaauguuaguauaaguaacaugaaaacauucuccuccgcauaagccugcgucagauuaaaaugaacugacaauuaacagcccaauaucuacaaucaaccaacaagucauuauuacccucacugucaacccaacacaggcaugcucauaaggaaagguuaaaaaaaguaaaaggaacucggcaaaucuuaccccgccuguuuaccaaaaacaucaccucuagcaucaccaguauuagaggcaccgccugcccagugacacauguuuaacggccgcgguacccuaaccgugcaaagguagcauaaucacuuguuccuuaaauagggaccuguaugaauggcuccacgaggguucagcugucucuuacuuuuaaccagugaaauugaccugcccgugaagaggcgggcauaacacagcaagacgagaagacccuauggagcuuuaauuuauuaaugcaaacaguaccaaaccugcauuaaaaauuucgguuggggcgaccucggagcagaacccaaccuccgagcaguacaugcuaagacuucaccagucaaagcgaacuacuauacucaauugauccaauaacuugaccaacggaacaaguuacccuagggauaacagcgcaauccuauucuagaguccauaucaacaauaggguuuacgaccucgauguuggaucaggacaucccgauggugcagccgcuauuaaagguucguuuguucaacgauuaaaguccuacgugaucugaguucagaccggaguaauccaggucgguuucuaucuacuuucaaauuccucccuguacgaaaggacaagagaaauaaggccuacuucacaaagcgccuucccccguaaaugauaucaucucaacuuaguauuauacccacacccacccaagaacaggguuugu <<<.......<<<<.....................................<......>.........<.....<<.....>>....>........>>.>>.............<<....>>......................>>>...........<<<.......>>>...<.<........>.>.<<<<<<.........<<<.<<..<<....>>...>>.>>>...<<.<...<<<<.<.....<<<<<.<<<..<<<.....>>>...<<<..<<<<........>>>>.>>>....>>>.>>>>>...<<.......>>......>.>>>>......>.>>..<<<<<<....<<<<....>>>><<<.<<<<<<<<<<.....<<..........>>.....>>>>>>>>>>..>>>.<<<<<<<<<<......>>>>>>>>>>.<.<<<......>>>.>..<<<.<<<...<..............<....<<<.........>>>....>.......<<<......>>>....................................>...>>>>>>........>>>>>>...<<<<<......>>>>>.........>>>>>><......<<..<<<....>>><<<<..<<<<........<<<<<.<<.....>>.>>>>>......<<<...<<<<.......................>>>>.......>>>.....<<......>>.>>>>.....>>>>..<<<<...<<<<<<<<.<<.........<......<<<<<<..<<<.........>>>...<<<<<<.............>>>>>>....<<<.<<<..<<<<<....>>>..>>>>><<<<<<......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>....>>.>>>>.....>..>>.>>>>>>>>>>>>.>>.....>.....<<<<<........>>>>>.......<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<....<..>......>>>>>>>>>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<.....<<<..<<<<.....>>>>..>>>...........>>.........<<<....>>>............>>>>..>>>>>>.......<<<..<.<<<<<<...<<.......>>...>>>>>>...>.>>.>.......<<<<<.<<<<<<..<<.<<<<<<......>>>>>>...>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>...<.<<<.<<<.................>>>.>>><<<<<...<<<....>>>.>>>>>......<<<................>>>......>..........<<<<.......>>>>.... ((.....(..((((.....................................(...[..).........(.....((.]...))....)........)).)).............((....))....)..................)).........(.(((.......))).[.(.(........).).((((((.........(((.((..((....))...)).)))...((.(...((((.(.....(((((.((((.(((....[)))...(((..((((.......{)))).)))..).))).))))).(.((.......))...)..).))))......).))..((((((....((((....)))).((.((((((((((.....((..........)).....))))))))))..))..((((((((((......))))))))))...(((......)))....(((.(((...(..............(.(..(((.........)))..).)....(..(((......))))...................................)...))))))........))))))...(((((......))))).........))))))(......((..(((....)))(((...((((......(.(((((.((.....)).)))))......(((...((((...............(..)....)))).......))).)...((......)).))))......)))..((((....(((((((.((..(....(........((((((.].((.........))....((((((.............))))))....(((.(((..(((((....)))..)))))(((((........)))))........((..........(((((.......)))))..)..)....)))....)).))))....)..))).))))))).)))).)).....)).{..(((((.....]}.))))).......((..(((.((......((((.((((((..(((((.((((((((....(())......)))))))))))))..(((......[)))((((((..........]))))))(.((.....((...(((....[..)))...))...........)).........(((....))).....)].....))))..))))))......((((..(.((((((.(.((.......)))..))))))...).)).).)......((((.((((((..((.((((((......))))))...)).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..}.))..))).))...(.(((.(((......(....).....))).)))(((((...(((....))).)))))......(((................)))......).........(((((.......))))..). Human mitochondrial ribosome in complex with mRNA, A/A tRNA and P/P tRNA; 16S mitochondrial rRNA 6zm6 AA 954 2.59 RF00177 URS00008F947B_9606 33602856 0003735 0005840 9606 auagguuugguccuagccuuucuauuagcucuuaguaagauuacacaugcaagcauccccguuccagugaguucacccucuaaaucaccacgaucaaaagggacaagcaucaagcacgcagcaaugcagcucaaaacgcuuagccuagccacacccccacgggaaacagcagugauuaaccuuuagcaauaaacgaaaguuuaacuaagcuauacuaaccccaggguuggucaauuucgugccagccaccgcggucacacgauuaacccaagucaauagaagccggcguaaagaguguuuuagaucacccccuccccaauaaagcuaaaacucaccugaguuguaaaaaacuccaguugacacaaaauagacuacgaaaguggcuuuaacauaucugaacacacaauagcuaagacccaaacugggauuagauaccccacuaugcuuagcccuaaaccucaacaguuaaaucaacaaaacugcucgccagaacacuacgagccacagcuuaaaacucaaaggaccuggcggugcuucauaucccucuagaggagccuguucuguaaucgauaaaccccgaucaaccucaccaccucuugcucagccuauauaccgccaucuucagcaaacccugaugaaggcuacaaaguaagcgcaaguacccacguaaagacguuaggucaagguguagcccaugagguggcaagaaaugggcuacauuuucuaccccagaaaacuacgauagcccuuaugaaacuuaagggucgaagguggauuuagcaguaaacugagaguagagugcuuaguugaacagggcccugaagcgcguacacaccgcccgucacccuccucaaguauacuucaaaggacauuuaacuaaaaccccuacgcauuuauauagaggagacaagucguaacaugguaaguguacuggaaagugcacuuggacgaacc ..((((..<<<<<<.)))).<<<<<<.<<..<<<<<<<<....<<<.<<<..<......>......<<.......<<<<....<<<.....>>>....>>>>..<<<<....<<...<<<....>>>..>>......>>>>.<<...>>.>>.<<<....>>>.....>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>.....<<<<<<<<.....(((.....((.>>>)).......)))..>>>>>..>>.>>>>>>....<<<((.....<<<<..<<<<...............<<<<<<......<<<.<<<.<<<......>>>..>>>.>>>.............<<....>>.>>>>>>.....>>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<.<<<<<......))..>>>>>.>.>>>.<<.......<<<<....>>>>.....>>..>>>>>><<<<<.<<<<<<<...<<<.<<<<<..<<<<<<<<<<.....<<........>>..........<<<<<<<.......<<.<<<..<<<<<<.......<<..<<<<<.....>>>.......>>..>>.....<<<....>>>.........>>>...>>>>>>>>....>>>>>>>..>>.>>>>>>>>.....<<<<.....>>>>.....<....<<<<<<<.......>>>>>>>....>.....>>>>>.....<<<<<<<.........>>>>>>>.....>>>...>>>>>>>>>>.>>....<..<<.<...<<<<<<..<<<<<......<<<....<<.....>>...>>>.......>>>>>.>>>>>>....>.>>...>.....<<<<<<<<<....>>>>>>>>>......... [.[[[[..(((((..]]]]]((((((.((..((((((((..(.(((.(((..(......)......(((......((((.(..(((.....))).)..))))..((((....((..((((....))).)))......)))).((...))))).(((....))).....)))))))......(.(((...(((((....)))).))))).)).)))))).....((((([[[.....(((.....((.]]])).......)))..)))))..)).))))))....((([[...(.((((...(((...............(((((((.....(((.(((.((........))..))).))).....).....(.((....))))))))).....)))....))))....((((((...((...((((.........))))...))))))))......{...(.(((((......]]..))))).))))).((.......((((....)))).....))...)))))(((((.(((((((...(((.(((((..((((((((((.....((........))..........(((((((.......((.(((...((((((.(....((..(((((.....))).......))..)).....(((....))).....).).)))...)).)))))....)))))))..)).)))))))).(...((((.....)))).....(....(((((((.......)))))))....)..)..))))).....(((((((.........))))))).....)))...)))))))))).))..(.(..((.(...((((((...((((..((..(((....((.....))...)))..).)..))))..))))))....).))...)..)..(((((((((....)))))))))}........ Human mitochondrial ribosome in complex with mRNA, A/A tRNA and P/P tRNA; 12S mitochondrial rRNA 6zm6 w 68 2.59 RF00005 URS00021D59F7_9606 33602856 0030533 9606 ugguauauaguuuaaacaaaacgaaugauuucgacucauuaaauuaugauaaucauauuuaccaacca <<<<<....<<<<.....>>>>.<<<<<.......>>>>>....<<<<<...>>>>>..>>>>>.... (((((.(..(((.......))).(((((.......)))))....(((((...)))))).))))).... Human mitochondrial ribosome in complex with mRNA, A/A tRNA and P/P tRNA; A-site tRNA 6zm6 x 70 2.59 RF00005 URS00021ED990_9606 33602856 0030533 0006412 9606 uagggaauaguuuaaaaaacagcugacuuucaaucagcagauggagguucaauuccuccuucccuaacca <<<<<<<..<<<<...>>>>.<<<<<.......>>>>>....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...)))).(((((.......)))))....(((((.......)))))))))))).... Human mitochondrial ribosome in complex with mRNA, A/A tRNA and P/P tRNA; P-site tRNA 6zm6 y 19 2.59 33602856 9606 uuuaagaacguguuuauuu ................... ................... Human mitochondrial ribosome in complex with mRNA, A/A tRNA and P/P tRNA; mRNA 6zm7 L5 3773 2.7 RF02543,RF02540 URS0000ABD7EF_9606 32680882 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcggcccggcggaucuuucccgcgcgggggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucgggggcccccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcgcucuccccccucccggcgcgccggggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccgggggaggccacgcgcgcgucccccgaagagggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcagacccgacgcccgccacgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagcggcgggccggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcugggucggucgcggccggcgccuagcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacaugagagguguagaauaagugggaggcccccggcgcccccccgguguccccgcgaggggcccggggcgggguccgccggcccugcgggccgccggugaaauaccacuacucugaucguuuuuucacugacccggugaggcgggggggcgagccccgaggggcucucgcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccggucccccgccgggguccggugcggagugcccuucguccugggaaacggggcgcggcuggaaaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>>..<<<<<<<<<<...<<<<<<<<........<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>...>>>>>>>>..>>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<<<..<<<<<<<...<<..<....<<<<<.<<<..<<<<..>>>>>>>>>>>>>..>>..>>>>...>>>>>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<<<<<<<<<<<<<<<<<...<<..<<<.<<.<<<<......<<<<<<<<..>>>>>>>>.......>>>>.>>>>>........>>>>>>..>>>>>>>>>>>....................<<<<<<.<<<<<<<............>>>>>>>.<<<<<<.<<<<.<<<<<<<<<<<.<<<<<.<<<<.<<...........>.>.>>>>.>>>>>.>.>>>>>>>.>>>...>>>>..>>>>.>>..<<<<<<<<<<.....>>>>>>>>.>>....>>>>>>.....>>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<......>>>>>>>..<<<<<...<<<..<<<..[[[..((((>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<......................<<<.<<<<<<<<<...<<<....<<<..<.<<<....<<.............>>..>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<..........))))..]]]...<.....>..................>>>>>>>>>....>>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<...<...>...>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<..<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<..<<..........>>.......>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<<<<<<....................................<........................>.................................................>>.>>>>>>>>>>...<<<<<.....<<<<.....<..............>................<<<<<<<<<<.......>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>>.<<<....>>>.>>)))].....<<<<<<<..<<<..)))))).>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<]]].>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.....<<<<<<<.<<..<<<<....<<<........<<<<<.<<<<....>>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>..............>>>>..>>>>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<....<<<<<......>>>>>...>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((...((((((((((.....)))))).)))).....)))....((((((((((....(((((((...(....((((((((..({((((......)))))....[[(...).(((....}]])))...).))))))))..)))))).)..))))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....(((((((((((..(((((((...((..((....((((.((...((.(..).)).))))))))..))..))))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((.(..((((......(.((((((())))))).).......))))..))))........))))))..)))))))))))....................((((((.((((((.....(.....)..)))))).((((((.((((.(((((((((((.(((((.(((..(..............)..)))).)))).).))))))).)))...))))..)))).))..((((((((((.....)))))))).))..[.)))))).....))).)))))...)))))...)))))))).<((((........))))((((((....(((((((((((((..(((..(((((........))))..)..)))...((....))...((((.((......).)))))..(((((...(((..(((..[[.....[[)))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((......................(((.((((((((....(((....(((..(.(((..(..................).))).)..)))..)).)....))))))...(((((((((.(......))))))))))....))))))))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.....{.(((((.(((...((...([...)))...))).....(...((.]....)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((..........]].....]]]..(......).................)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...((....(((....)))..........((.(((((...(....)..)))))))......))....))...(((((........)))))]]((((....(((((...((.((((....)))).))..((((....)))...(...((((((...(((((((((((((((((((((((..{{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....(((((((.......))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((...(([...)...])........)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(..(((.....((((....)))).....))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.(.......((((.((((((..(((((.(((((((((.(((((((..(....................................................................................................................)..)))))))...(((((.....((((.....((............))................((((((((((.......))))))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a..)..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}}.)))))..)).))...))))...)))).((((...((((.....}.......))))...))))..)))...).)))))).....(((((((.((..((((.(..(((........(((((.((((.(.))))).))))).......)))...(((...((......(((.(((((.(......).)))))))).....))...)))...........)..))))..)))))))))(((((.(..(.......)..)....((.(((((((.((.....((((.(..(((((......)))))..)))))....))....)))).))).))..))))).. SARS-CoV-2 Nsp1 bound to the human CCDC124-80S-EBP1 ribosome complex; 28S ribosomal RNA 6zm7 L7 120 2.7 RF00001 URS00000F9D45_9606 32680882 0003735 0005840 9606 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. SARS-CoV-2 Nsp1 bound to the human CCDC124-80S-EBP1 ribosome complex; 5S ribosomal RNA 6zm7 L8 156 2.7 RF00002 URS0000005270_9606 32680882 0003735 0005840 9606 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<<<<....>>>>.....<.<<<......>>.............>>>..>...>>>....<<....>><<<<<<<<<.....>>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))(((((((((.....))))))))).................... SARS-CoV-2 Nsp1 bound to the human CCDC124-80S-EBP1 ribosome complex; 5.8S ribosomal RNA 6zm7 S2 1740 2.7 RF01960,RF01959,RF00177 URS0000726FAB_9606 32680882 0003735 0005840 9606 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucugaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucgcuccucuccuacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgccccccguggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcgggcguccccgcccucucggccggggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggucggcccacggcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<....<<....<<<<<..................<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<........>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<.<.....>>>>>>>>.>>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....<<.....<<.<<<....>>>.>>.......>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<.......................<<.<.............>>>...<<<<<<.<.......<<...<.......>.<<<<.......>>>>...>>......>.>>>..>>>........<.<<.<<<.<<<...............>>>.>>>.>>.>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<.......>>>>.>>>>.....>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<...<<<...................>>>.....>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..((....(((((...((.........[...((.....((.(((.....))).))......))......)).((((...((((........))))...))))((..(((((...(......)..)))))......)).(]((((.(((.(.....))))))))))).)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).).....(.(((.(((.(((....))).)).).).).))......((..(...........)..)).........((((([[....(.((((.....((..]])).......))))))))))..)))))).)))..[......(.([[...(.(.((...(((..(.......................((................))...((((((.(.......((..((.......)).((.........))....))......).)))..)))........(.((.(.(..(.................)..).).)).)....)....(((..(...(...((((..((..((((((((...((........))......))))))))..)).......((....))...))))..)...)...))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.((((......)))))))))).)..)))...((..]]))...))...].))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((...(...((((..((((((((((((.......)))).)))).....))))..))))..).....(((((.....)))))........)))....))).))).....).))))).....).)))))...)).)))).))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..((((.((...(((((....(...(............)....)......)))))...)).))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}........ SARS-CoV-2 Nsp1 bound to the human CCDC124-80S-EBP1 ribosome complex; 18S ribosomal RNA 6zm7 CC 75 2.7 RF00005 URS0000E60BA3_9606 32680882 0030533 0006412 9606 uccgauauagcguaacggcuaucacaucacgcuuucaccguggagaccgggguucgacuccccguaucggagcca <<<<<<<..<.<..........>.>.<<<<<.......>>>>>....<<<<<.......>>>>>>>>>>>>.... (((((((..(.(.....[....).).(((((.......)))).)...(((((..]....)))))))))))).... SARS-CoV-2 Nsp1 bound to the human CCDC124-80S-EBP1 ribosome complex; tRNA 6zme L5 3773 3.0 RF02543,RF02540 URS0000ABD7EF_9606 32680882 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcggcccggcggaucuuucccgcgcgggggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucgggggcccccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcgcucuccccccucccggcgcgccggggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccgggggaggccacgcgcgcgucccccgaagagggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcagacccgacgcccgccacgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagcggcgggccggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcugggucggucgcggccggcgccuagcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacaugagagguguagaauaagugggaggcccccggcgcccccccgguguccccgcgaggggcccggggcgggguccgccggcccugcgggccgccggugaaauaccacuacucugaucguuuuuucacugacccggugaggcgggggggcgagccccgaggggcucucgcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccggucccccgccgggguccggugcggagugcccuucguccugggaaacggggcgcggcuggaaaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..[[[..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>>..<<<<<<<<<<....<<<<<<<........<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>...>>>>>>.>..>>>>>>>>>>.......<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<<<..<<<<<<<...<<..<....<<<<<.<<<..<<<<..>>>>>>>>>>>>>..>>..>>>>...>>>>>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<<<<<<<<<<<<<<<<<...<<..<<<.<<.<<<<......<<<<<<<<..>>>>>>>>.......>>>>.>>>>>........>>>>>>..>>>>>>>>>>>....................<<<<<<.<<<<<<<............>>>>>>>.<<<<<<.<<<<.<<<<<<<<<<<.<<<<<.<<<<.<..............>.>>>>.>>>>>.>.>>>>>>>.>>>...>>>>..>>>>.>>..<<<<<<<<<<.....>>>>>>>>.>>....>>>>>>.....>>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<......>>>>>>>..<<<<<...<<<..<<<..(((...(((>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<......................<<<.<<<<<<<<<...<<<....<<<..<.<<<....<<.............>>..>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<..........)))...)))...<.....>..................>>>>>>>>>....>>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<<....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<...<...>...>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<..<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<<<<<<<<<<<<..{{{..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>.>.>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<...............<<<<<....<....>.....>>>>><<.<<<<<<<<<<<..<<..........>>.......>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>>.<<<<<.......>>>>>.........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>...>>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<<.<<<<<<<<..<<....................................<........................>.................................................>>...>>>>>>>>...<<<<<.....<<<<........<........>...................<<<<<<<<<<.......>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>>.<<<....>>>.>>)))]......((((((..(((..>>>>>>.)))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]].....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<.}}}..>>>>..>>.>>...>>>>...>>>><<<<....<<<<<...........>>>>>....>>>>.>>>...>.>>>>>>.....<<<<<<<.<<..<<<<....<<<........<<<<<.<<<<....>>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>..............>>>>..>>>>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<....<<<<<......>>>>>...>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((...((((((.(((.....))).)).)))).....)))....((((((((((....(((((((...(....((((((((..({((((......)))))....[[(...).(((....}]])))...).))))))))..)))))).)..))))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....(((((((((((..(((((((...((..((....((((.((...((.(..).)).))))))))..))..))))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((.(..((((......(.((((((())))))).).......))))..))))........))))))..)))))))))))....................((((((.((((((.....(.....)..)))))).((((((.((((.(((((((((((.(((((.(((..(..............)..)))).)))).).))))))).)))...))))..)))).))..((((((((((.....)))))))).))..[.)))))).....))).)))))...)))))...)))))))).<((((........))))((((((....(((((((((((((..(((..(((((........))))..)..)))...((....))...((((.(.........)))))..(((((...(((..(((..[[.....[[)))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((......................(((.((((((((....(((....(((..(.(((..(..(.............).).))).)..)))..)).)....))))))...(((((((((.(......))))))))))....))))))))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.....{.(((((.(((...((...([...)))...))).....(...((.]....)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((..........]].....]]]..(......).................)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...((....(((....)))..........((.((((....(....)...))))))......))....))...(((((........)))))]]((((....(((((...((.((((....)))).))..((((....)))...(...((((((...(((((((((((((((((((((((..{{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....(((((((.......))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((...(([...)...])........)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(..(((.....((((....)))).....))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.(.......((((.((((((..(((((.(((((((((.(((((((..(.(...............................................................................................................)..)..)))))))...(((((.....((((.....((............))................((((((((((.......))))))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a..)..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}}.)))))..)).))...))))...)))).((((...((((.....}.......))))...))))..)))...).)))))).....(((((((.((..((((.(..(((.........((((.((((.(.))))).))))........)))...(((..(((.....(.((.(((((((......)))))))).))....)))..)))...........)..))))..)))))))))(((((.(..(.......)..)....((.(((((((.((.....((((.(..(((((......)))))..)))))....))....)))).))).))..))))).. SARS-CoV-2 Nsp1 bound to the human CCDC124-80S-eERF1 ribosome complex; 28S ribosomal RNA 6zme L7 120 3.0 RF00001 URS00000F9D45_9606 32680882 0003735 0005840 9606 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. SARS-CoV-2 Nsp1 bound to the human CCDC124-80S-eERF1 ribosome complex; 5S ribosomal RNA 6zme L8 156 3.0 RF00002 URS0000005270_9606 32680882 0003735 0005840 9606 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<<<<....>>>>.....<.<<<......>>.............>>>..>...>>>....<<....>><<<<<<<<<.....>>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))((((((((.......)))))))).................... SARS-CoV-2 Nsp1 bound to the human CCDC124-80S-eERF1 ribosome complex; 5.8S ribosomal RNA 6zme S2 1740 3.0 RF01960,RF01959,RF00177 URS0000726FAB_9606 32680882 0003735 0005840 9606 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucugaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucgcuccucuccuacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgccccccguggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcgggcguccccgcccucucggccggggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggucggcccacggcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<....<<....<<<<<..................<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<........>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<.<.....>>>>>>>>.>>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....<<.....<<.<<<....>>>.>>.......>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<.......................<<.<<...........>>>>...<<<<<<.<.......<<...<.......>.<<<<.......>>>>...>>......>.>>>..>>>........<.<<.<<<.<<<...............>>>.>>>.>>.>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<......<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<.......>>>>.>>>>.....>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.......>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<...<<<...................>>>.....>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..((....(((((...((.........[...((.....((.(((.....))).))......))......)).((((...((((........))))...))))((..(((((...(......)..)))))......)).(]((((.(((.(.....))))))))))).)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).).....(.((..(((.(((....))).)).)...).))......((..(...........)..)).........((((([[....(.((((.....((..]])).......))))))))))..)))))).)))..[......(.([[...(.(.((...(((..(.......................((.(.............)))...((((((.(.......((..((.......)).(((.......)))....))......).)))..)))........(.((.(.(..((...............))..).).)).)....)....(((..(...(...((((..(((.((((((((...((........))......)))))))).))).......((....))...))))..)...)...))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.((((......)))))))))).)..)))...((..]]))...))...].))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((..(...(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((...(...((((..((((((((((((.......)))).)))).....))))..))))..).....(((((.....)))))........)))....))).))).....).))))).....).)))))...)).)))).))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(..(((((((.(((..((((.((...(((((....(...(............)....)......)))))...)).))))..))).))))))).)..)).))))...).))...)..)..(((((((((....)))))))))}........ SARS-CoV-2 Nsp1 bound to the human CCDC124-80S-eERF1 ribosome complex; 18S ribosomal RNA 6zme CC 75 3.0 RF00005 URS0000E60BA3_9606 32680882 0030533 0006412 9606 uccgauauagcguaacggcuaucacaucacgcuuucaccguggagaccgggguucgacuccccguaucggagcca <<<<<<<..<.<..........>.>.<<<<<.......>>>>>....<<<<<.......>>>>>>>>>>>>.... (((((((..(.(.....[....).).(((((.......)))).)...(((((..]....)))))))))))).... SARS-CoV-2 Nsp1 bound to the human CCDC124-80S-eERF1 ribosome complex; tRNA 6zmi L5 3773 2.6 RF02543,RF02540 URS0000ABD7EF_9606 32680882 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcggcccggcggaucuuucccgcgcgggggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucgggggcccccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcgcucuccccccucccggcgcgccggggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccgggggaggccacgcgcgcgucccccgaagagggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcagacccgacgcccgccacgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagcggcgggccggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcugggucggucgcggccggcgccuagcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacaugagagguguagaauaagugggaggcccccggcgcccccccgguguccccgcgaggggcccggggcgggguccgccggcccugcgggccgccggugaaauaccacuacucugaucguuuuuucacugacccggugaggcgggggggcgagccccgaggggcucucgcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccggucccccgccgggguccggugcggagugcccuucguccugggaaacggggcgcggcuggaaaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..[[[..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>>..<<<<<<<<<<...<<<<<<<<........<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>...>>>>>>>>..>>>>>>>>>>.......<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<<<..<<<<<<<...<<..<.....<<<<.<<<..<<<<..>>>>>>>>>>>.>..>>..>>>>...>>>>>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<<<<<<<<<<<<<<<<<...<<..<<<.<<.<<<<......<<<<<<<<..>>>>>>>>.......>>>>.>>>>>........>>>>>>..>>>>>>>>>>>....................<<<<<<.<<<<<<<...<.....>..>>>>>>>.<<<<<<.<<<<.<<<<<<<<<<<.<<<<<.<<<<..<...........>...>>>>.>>>>>.>.>>>>>>>.>>>...>>>>..>>>>.>>..<<<<<<<<<<.....>>>>>>>>.>>....>>>>>>.....>>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<......>>>>>>>..<<<<<...<<<..<<<..((((..(((>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<......................<<<.<<<<<<<<<...<<<....<<<..<.<<<....<<.............>>..>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<..........)))..))))...<.....>..................>>>>>>>>>....>>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<.<.<....>>.>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<..<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..{{{..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<..<<..........>>.......>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<<.<<<<<<<<..<<....................................<........................>.................................................>>...>>>>>>>>...<<<<<.....<<<<.....<..<........>..>................<<<<<<<<<<.......>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>>.<<<....>>>.>>)))]......((((((..(((..>>>>>>.)))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]].....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<}}}.>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.....<<<<<<<.<<..<<<<....<<<........<<<<<.<<<<....>>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>..............>>>>..>>>>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<....<<<<<......>>>>>...>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((...((((((((((.....)))))).)))).....)))....((((((((((....(((((((...(....((((((((..({((((......)))))....[[(...).(((....}]])))...).))))))))..)))))))...))))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....(((((((((((..(((((((...((..((....((((.((...((.(..).)).))))))))..))..))))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((.(..((((......(.((((((())))))).).......))))..))))........))))))..)))))))))))....................((((((.((((((.....(.....)..)))))).((((((.((((.(((((((((((.(((((.(((..(..............)..)))).)))).).))))))).)))...))))..)))).))..((((((((((.....)))))))).))..[.)))))).....))).)))))...)))))...)))))))).<((((........))))((((((....(((((((((((((..(((..(((((........))))..)..)))...((....))...((((.((......).)))))..(((((...(((..(((..[[.....[[)))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((......................(((.((((((((....(((....(((..(.(((..(..(.............).).))).)..)))..)).)....))))))...(((((((((.(......))))))))))....))))))))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.....{.(((((.(((...((...([...)))...))).....(...((.]....)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((..........]].....]]]..(......).................)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...((....(((....)))..........((.(((((...(....)..)))))))......))....))...(((((........)))))]]((((....(((((...(((((((....)))))))..((((....)))...(...((((((...(((((((((((((((((((((((..{{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....(((((((.......))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((...(([...)...])........)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(..(((.....((((....)))).....))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.(.......((((.((((((..(((((.(((((((((.(((((((..(.(...............................................................................................................)..)..)))))))...(((((.....((((.....((............))................((((((((((.......))))))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a..)..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}}.)))))..)).))...))))...)))).((((...((((.....}.......))))...))))..)))...).)))))).....((((((..((..((((.(..(((........(((((.((((.(.))))).))))).......)))...(((...((.....((((.(((((.(......).)))))))))....))...)))...........)..))))..)).))))))(((((.(..(.......)..)....((.(((((((.((.....((((.(..(((((......)))))..)))))....))....)))).))).))..))))).. SARS-CoV-2 Nsp1 bound to the human LYAR-80S ribosome complex; 28S ribosomal RNA 6zmi L7 120 2.6 RF00001 URS00000F9D45_9606 32680882 0003735 0005840 9606 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. SARS-CoV-2 Nsp1 bound to the human LYAR-80S ribosome complex; 5S ribosomal RNA 6zmi L8 156 2.6 RF00002 URS0000005270_9606 32680882 0003735 0005840 9606 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<<<<....>>>>.....<.<<<......>>.............>>>..>...>>>....<<....>><<<<<<<<<.....>>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))(((((((((.....))))))))).................... SARS-CoV-2 Nsp1 bound to the human LYAR-80S ribosome complex; 5.8S ribosomal RNA 6zmi S2 1740 2.6 RF01960,RF01959,RF00177 URS0000726FAB_9606 32680882 0003735 0005840 9606 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucugaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucgcuccucuccuacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgccccccguggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcgggcguccccgcccucucggccggggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggucggcccacggcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<....<<....<<<<<..................<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<........>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<.<.....>>>>>>>>.>>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....<<.....<<.<<<....>>>.>>.......>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<.......................<<.<.............>>>...<<<<<<.<.......<<...<.......>.<<<<.......>>>>...>>......>.>>>..>>>........<.<<.<<<.<<<...............>>>.>>>.>>.>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<......<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<.......>>>>.>>>>.....>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.......>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<...<<<...................>>>.....>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..((....(((((...((.........[...((.....((.(((.....))).))......))......)).((((...((((........))))...))))((..(((((...(......)..)))))......)).(]((((.(((.(.....))))))))))).)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).).....(.(((.(((.(((....))).)).).).).))......((..(...........)..)).........((((([[....(.((((.....((..]])).......))))))))))..)))))).)))..[......(.([[...(.(.((...(((..(.......................((................))...((((((.(.......((..((.......)).((.........))....))......).)))..)))........(.((.(.(..((...............))..).).)).)....)....(((..(...(...((((..(((.((((((((...((........))......)))))))).))).......((....))...))))..)...)...))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.((((......)))))))))).)..)))...((..]]))...))...].))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((.(..(((.(((((....)))..(.((......)))...)).)))....(((...(...((((..((((((((((((.......)))).)))).....))))..))))..).....(((((.....)))))........))).)..))).))).....).))))).....).)))))...)).)))).))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..((((.((...(((((....(...(............)....)......)))))...)).))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}........ SARS-CoV-2 Nsp1 bound to the human LYAR-80S ribosome complex; 18S ribosomal RNA 6zmi CC 75 2.6 RF00005 URS0000E60BA3_9606 32680882 0030533 0006412 9606 uccgauauagcguaacggcuaucacaucacgcuuucaccguggagaccgggguucgacuccccguaucggagcca <<<<<<<..<.<..........>.>.<<<<<.......>>>>>....<<<<<.......>>>>>>>>>>>>.... (((((((..(.(.....[....).).(((((.......)))).)...(((((..]....)))))))))))).... SARS-CoV-2 Nsp1 bound to the human LYAR-80S ribosome complex; tRNA 6zmo L5 3773 3.1 RF02543,RF02540 URS0000ABD7EF_9606 32680882 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcggcccggcggaucuuucccgcgcgggggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucgggggcccccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcgcucuccccccucccggcgcgccggggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccgggggaggccacgcgcgcgucccccgaagagggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcagacccgacgcccgccacgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagcggcgggccggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcugggucggucgcggccggcgccuagcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacaugagagguguagaauaagugggaggcccccggcgcccccccgguguccccgcgaggggcccggggcgggguccgccggcccugcgggccgccggugaaauaccacuacucugaucguuuuuucacugacccggugaggcgggggggcgagccccgaggggcucucgcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccggucccccgccgggguccggugcggagugcccuucguccugggaaacggggcgcggcuggaaaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>>..<<<<<<<<<<...<<<<<<<<........<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>...>>>>>>>>..>>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<......>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<<<..<<<<<<<...<<..<....<<<<<.<<<..<<<<..>>>>>>>>>>>>>..>>..>>>>...>>>>>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<.<<<<<<<<<<<<<<<...<<..<<<.<<.<<<<......<<<<<<<<..>>>>>>>>.......>>>>.>>>>>........>>>>>>..>>>>>>>>>>>....................<<<<<<.<<<<<<<...<.....>..>>>>>>>.<<<<<<.<<<<.<<<<<<<<<<<.<<<<<.<<<<..<...........>...>>>>.>>>>>.>.>>>>>>>.>>>...>>>>..>>>>.>>..<<<<<<<<<<.....>>>>>>>>.>>....>>>>>>......>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<......>>>>>>>..<<<<<...<<<..<<<..[[[..((((>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<......................<<<.<<<<<<<<<...<<<....<<<..<.<<<....<<.............>>..>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<..........))))..]]]...<.....>..................>>>>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<...<...>...>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<..<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<..<<..........>>.......>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>>.<<<<<.......>>>>>.........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<<<<<<....................................<........................>.................................................>>.>>>>>>>>>>...<<<<<.....<<<<........<........>...................<<<<<<<<<<.......>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>>.<<<....>>>.>>)))].....<<<<<<<..<<<..)))))).>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<]]].>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.....<<<<<<<.<<..<<<<....<<<........<<<<<.<<<<....>>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>..............>>>>..>>>>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<....<<<<<......>>>>>...>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((...((((((((((.....)))))).)))).....)))....((((((((((....(((((((........((((((((..({((((......)))))....[[(...).(((....}]])))...).)))))))...)))))))...))))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....(((((((((((..(((((((...((..((....((((.((...((.(..).)).))))))))..))..))))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((.(..((((......(.((((((())))))).).......))))..))))........))))))..)))))))))))...........[........((((((.((((((.....(.....)..)))))).((((((.((((.(((((((((((.(((((.(((..(..............)..)))).)))).).))))))).)))...))))..)))).))..((((((((((.....)))))))).))..[.)))))).....))).)))))...)))))...)))))))).<((((........))))((((((....(((((((((((((..(((..(((((........))))..)..)))...((....))...((((.((......).)))))..(((((...(((..(((..[......[[)))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((......................(((.((((((((....(((....(((..(.(((..(..................).))).)..)))..)).)....))))))...(((((((((.(......))))))))))....))))))))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.....{.(((((.(((...((...([...)))...))).....(...((.]....)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((..........]]......]]..(......)......]..........)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...((....(((....)))..........((.((((....(....)...))))))......))....))...(((((........)))))]]((((....(((((...((.((((....)))).))..((((....)))...(...((((((...(((((((((((((((((((((((..{{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....(((((((.......))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((...(([...)...])........)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.(.......((((.((((((..(((((.(((((((((.(((((((..(....................................................................................................................)..)))))))...(((((.....((((.....((............))................((((((((((.......))))))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a..)..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}}.)))))..)).))...))))...)))).((((...((((.....}.......))))...))))..)))...).)))))).....((((((..((..((((.(..(((........(((((.((((.(.))))).))))).......)))...(((..(((.....(.((.(((((.(......).)))))).))....)))..)))...........)..))))..)).))))))(((((.(..(.......)..)....((.(((((((.((.....((((.(..(((((......)))))..)))))....))....)))).))).))..))))).. SARS-CoV-2 Nsp1 bound to the human LYAR-80S-eEF1a ribosome complex; 28S ribosomal RNA 6zmo L7 120 3.1 RF00001 URS00000F9D45_9606 32680882 0003735 0005840 9606 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. SARS-CoV-2 Nsp1 bound to the human LYAR-80S-eEF1a ribosome complex; 5S ribosomal RNA 6zmo L8 156 3.1 RF00002 URS0000005270_9606 32680882 0003735 0005840 9606 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<<<<....>>>>.....<.<<<......>>.............>>>..>...>>>....<<....>><<<<<<<<<.....>>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))((((((((.......)))))))).................... SARS-CoV-2 Nsp1 bound to the human LYAR-80S-eEF1a ribosome complex; 5.8S ribosomal RNA 6zmo S2 1740 3.1 RF01960,RF01959,RF00177 URS0000726FAB_9606 32680882 0003735 0005840 9606 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucugaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucgcuccucuccuacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgccccccguggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcgggcguccccgcccucucggccggggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggucggcccacggcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<..<.....<<<.<....<<....<<<<<..................<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<........>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<.<.....>>>>>>>>.>>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>>>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....<<.....<<.<<<....>>>.>>.......>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<.......................<<.<.............>>>...<<<<<<.<.......<<...<.......>.<<<<.......>>>>...>>......>.>>>..>>>........<.<<.<<<.<<<...............>>>.>>>.>>.>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<......<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<.......>>>>.>>>>.....>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.......>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<...<<<...................>>>.....>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..((....(((((...((.........[...((.....((.(((.....))).))......))......)).((((...((((........))))...))))((..(((((...(......)..)))))......)).(]((((.(((.(.....))))))))))).)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).).....(.(((.(((.(((....))).)).).).).))......((..(...........)..)).........((((([[....(.((((.....((..]])).......))))))))))..)))))).)))..[......(.([[...(.(.((...(((..(.......................((................))...((((((.(.......((..((.......)).((.(......)))....))......).)))..)))........(.((.(.(..((...............))..).).)).)....)....(((..(...(...((((..((..((((((((...((........))......))))))))..)).......((....))...))))..)...)...))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.((((......)))))))))).)..)))...((..]]))...))...].))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((.(..(((.(((((....)))..(.((......)))...)).)))....(((...(...((((..((((((((((((.......)))).)))).....))))..))))..).....(((((.....)))))........))).)..))).))).....).))))).....).)))))...)).)))).))).(...((.(((........(.......((..((((....))))..))....).........))).))......(.....(((((..........))))).....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..((((.((...(((((....(...(............)....)......)))))...)).))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}........ SARS-CoV-2 Nsp1 bound to the human LYAR-80S-eEF1a ribosome complex; 18S ribosomal RNA 6zmo CB 87 3.1 RF00005 URS00021ED910_9606 32680882 0030533 0006412 9606 gucaggauggccgaguggucuaaggcgccagacucaaguucuggucuccggauggaggcguggguucgaaucccacuucugacacca <<<<<<...<<<...........>>><<<<<<.......>>>>>><<<<....>>>>..<<<<<.......>>>>>.>>>>>>.... (((((.(..(((...........))).(((((.......))))).((((....))))..(((((.......)))))).))))).... SARS-CoV-2 Nsp1 bound to the human LYAR-80S-eEF1a ribosome complex; tRNA 6zmo CC 75 3.1 RF00005 URS0000E60BA3_9606 32680882 0030533 0006412 9606 uccgauauagcguaacggcuaucacaucacgcuuucaccguggagaccgggguucgacuccccguaucggagcca <<<<<<<..<.<..........>.>.<<<<<.......>>>>>....<<<<<.......>>>>>>>>>>>>.... (((((((..(.(.....[....).).(((((.......)))).)...(((((..]....)))))))))))).... SARS-CoV-2 Nsp1 bound to the human LYAR-80S-eEF1a ribosome complex; tRNA 6zmw 7 28 3.7 32883864 9606 aaaaaaaaaaaaaaaaaaaaaaaaaaaa ............................ ............................ Structure of a human 48S translational initiation complex; mRNA 6zmw A 1719 3.7 RF01960,RF01959,RF00177 URS0000726FAB_9606 32883864 0003735 0005840 9606 uaccugguugauccugccaguagcaunugcuugucucaaagauuaagccaugcaugucugaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuauggunccuunggucgcucgcuccuacuuggauaacugugguanuucuagngcuaauanaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgccccccguggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcnaauuacccacucccgacccgggganguagugangaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauancguauauuaaaguugcugcaguunaaaagcucguaguungaucuugggagcggccccgccccucucggcggcccgaagcguuuacuuugaaaaaanuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagancgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccacnaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauucngauaacgaacgagacucuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauunagucccugcccuuuguacacaccgnccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccgggggcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucgnancaagguuuccguaggugnnccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<.........<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<....<<....<<<<<.............<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<........>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<<......>>>>>>>>.>>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>......>>.>.....<.<<...<<..<<....>>..>>.....>>..>.....<<..<...........>..>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<....<<<..........>>><<.............>>...<<<<<<.<.......<<...<.......>.<<<<.......>>>>...>>......>.>>>..>>>........<.<<.<<<.<.<...............>>..>>>.>>.>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<........>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<......>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<......<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<.......>>>>.>>>>.....>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.......>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>..........<.<<<<<..........>>>>>>..........>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<.......................>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..((....(((.....((....[...((.....((.(((.....))).))......))......)).((((...((((........))))...))))((..(((((...(......)..)))))......)).(]((((.((((......)))))))))...)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).).....(......((.(((....))).))........)....(.((..(...........)..))......)..((((([[....(.((((.....((..]])).......))))))))))..)))))).)))..[......(.([[...(.(.((...(((..(.....((..........)).((.............))...((((((.(.......((..((.......)).(((.......)))....))......).)))..)))........(.((.(.(...(...............)...).).)).)....)....(((.((...(...((((..((..((((((((...((........))......))))))))..)).......((....))...))))..)...))..))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.(((........))))))))).)..)))...((..]]))...))...].))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.(((.((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((...(...((((..((((((((((((.......)))).)))).....))))..))))..).....(((((.....)))))........)))....))).))).....).))))).....).)))))...))..))).))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..((((.((...((((.(......................)))))...)).))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}........ Structure of a human 48S translational initiation complex; 18S rRNA 6zmw w 75 3.7 RF00005 URS0000326EAC_9606 32883864 0030533 0006412 9606 agcagaguggcgcagcggaagcgugcugggcccauaacccagaggucgauggaucgaaaccauccucugcuacca <<<<<<...<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>.>>>>>>.... .((((((...(((.......)))..(((((.......))))).....(((((.......)))))))))))..... Structure of a human 48S translational initiation complex; Initiator Met-tRNA-i 6zp4 2 1721 2.9 RF01960,RF01959,RF00177 URS0000868562_9606 32680882 0003735 0005840 9606 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucguacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgccgcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcgggcgggcgguccgccgcgaggcgagccaccgcccguccccgcccucucggccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgaccggucggcguaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggugcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<....<<....<<<<..........<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<<.....>.>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<.>>>>>>>..>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....<<<<<<<<<.............>>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<.....<<.<.<<<<<<<<<<<.<<<<....>>>>....>>>>>>>>>>>.>.>>................<<<<<<.<.......<<...<.......>.<<<<.>>>>...>>......>.>>>..>>>........<.<<.<<<<<...................>>>>>.>>.>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<<....>>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<......>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<..>>>.>>>>>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<...<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<<.<................>..>.>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>....>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..((....(((.....(([...((.....((.(((.....))).))......))......)).((((...((((........))))...))))((..(.(((...(......)..))).)......)).(]((((.((...)))))))...)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((........))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).).....(((((((((.............)))))).)))....(.((..(...........)..))......)..((((([[....(.((((.....((..]])).......))))))))))..)))))).)))..[......(.([[...(.(.((...(((........((.(.((.((((((((.((((....))))....)))))))).)).).))...(......).....((.(((.(.......((..((.......)).(((.)))....))......).)))...))........(.((.(((((...................))))).)).).........(((..(...(...(((...(((.((((.((....((........)).......)).)))).))).......((....))....)))..)...)...))..))))...)).)....(((((.....(...((((.........))))...)..)))))......{...(((.((.(((..(.((((((.((((......)))))))))).)..)))...((..]]))...))...].))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((........((..((........))..))......)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((...(...((((..(((((((((((()))).))))))))..))))..).....(((((.....)))))........)))....))).))).....).))))).....).)))))...)).)))).))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(....((.((..(.(((.((((.(((..((((.((...((.(((.(.................).).)).))...)).))))..))).)))).))))..)).)).....).))...)..)..(((((((((....)))))))))}........ SARS-CoV-2 Nsp1 bound to a human 43S preinitiation ribosome complex - state 2; 18S ribosomal RNA 6zp4 1 75 2.9 RF00005 URS00021ED8FE_9606 32680882 0030533 0006412 9606 agcagaguagcgcagcggaagcgugcugggcccauaacccagaggucgauggaucgaaaccauccucugcuacca <<<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... .((((((..((((....[..)))).(((((.......))))).....(((((..]....)))))))))))..... SARS-CoV-2 Nsp1 bound to a human 43S preinitiation ribosome complex - state 2; tRNA 6zqa D2 523 4.4 URS000007769E_559292 32943521 559292 augcgaaagcaguugaagacaagugcuugucguucguuaaaauggccucgucaaacgguggagagagucgcuaggugaucgucagaucugccuagucucuauacagcguguuuaauugacauggguugaugcguauugagagauacaauuugggaagaaauucccagaguguguuucuuuugcguuuaaccugaacagucucaucgugggcaucuugcgauuccauuggugagcagcgaaggauuugguggauuacuagcuaauagcaaucuauuucaaagaauucaaacuugggggaaugccuuguugaauagccggucgcaagacugugauucuucaaguguaaccuccucucaaaucagcgauaucaaacguaccccgugaaacaccgggguaucuguuugguggaaccugauuagaggaaacucaaagagugcuaugguauggugacggagugcgcuggucaagaguguaaaagcuuuuugaacagagagcauuuccggcagcagagauuucagcuguu .<<<....>>>...<<<<<<<<<..>>>>>>.>>>..............<<<<<<<<.<<...<<<<..<<<<<<<<<<<....>>>>.>>>>>>>>>>>...>>.>>>......>>>>>..<<<<<<..<<<<...<<<<<.<<<<.<<<<<<<<....>>>>>>>>.>>>>.>>>>>..>>>>.>>>>>>.......<<<<<<<<<<<...........>>>>>.>>>>>>.........................<<<...>>>.........................<<<<<..<<<<<<<..<<<<...<<<<<....>>>>>.>.>>>..>>>>.>>.>>>>>>.....<<<<<<...<<<<<<<<<<<<<<<<........>>>>>>>.>.>>>>>>>>....>>>>>>.................................<<<<<<<<.<<<.<<<<<<<<......>>>>.>>>>.>>>...>>>>.>>>><<<<<.<<<..>>>.>>>>>. .(((....)))...(((((((((..)))))).)))..............((((((((.(((..((((..(((((((((((....)))).))))))))))).).)).)))......)))))..(((((....((.(..((((.(.(((.((((((((....)))))))).))).).)))).).))...))))).....(.((((((((((((.....)....))))).)))))))........................(((...))).........................(((((..(((((((..((((..((.(((....))).).)))))..)))).)).)))))).....((((((....((((((((((((((((.....).))))))).).))))))).....)))))).................................((((.(((.(((.(((((((........))).)))).)))...)))..)))).((((.((.(.))).)))).. Cryo-EM structure of the 90S pre-ribosome from Saccharomyces cerevisiae, state A (Poly-Ala); 5ETS RNA 6zqa D3 787 4.4 RF01960,RF01959,RF00177 URS00021ED90C_559292 32943521 0003735 0005840 559292 aagauaguuaucugguugauccugccagucauaugcuugucucaagacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauugcucguaguugaacuauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgaggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcgggaaacucaccagguccagacacaauauuugugggugguggugcaugugaugcccuuguucuggcgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaaaacuccgucggggaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggaaauuuggacaaacuuggucauuuagaggaacuaaguuuccguaggugaaccugcgga ...........................<<.<<<<<<...<...........>.....<<<<<<<.<<<<<....>>>>>.>>>.>>>>......<<..<...........>..>>.........<<<<<<.......<<<....>>>..................>>>>>>..>>>>>>>>.<.<<...<<<.<<...>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>..>>.>>>.>>>...>>>...>>.>............<<...<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>..>>..................<<.........>>.....<<<<<<<<<<<<..<<.<<<<<<..<<<.<<<<.........<<<<<.<....<<<<<...>>>>>......<<<.........>>>...>.>>>>>>>>>.>>>.....<<<<<<<............<<<..<<<<....>>>>..>>>.....>>>>>>>............>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>............>>>>>..<<<<.<<....<<<<<<<<.<<<..<.<<......<<<<<<<...<<.<<<......>>>.>>...>>>>>>>.....>>.>..>>>.>>>>>>>>...>>.>>>>....<<<<<<<<....>>>>>>>> ..........................(((.((((((...(.(.......).).....((((.((((((((....))))))))..))))....(.(((.(...........)).))......)..((((((.(.....(((....)))...............)..))))))..)))))))))(.((...(((.((...))...((.((((.((...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)).))).).)..))))...)).)............((...(((...(((((((.(((........))))))))))...)))..))..................((.........)).....((((((((((((..((.((((((..((((.(((.........(((((.(....(((((...)))))....(.((..(....)...)))..).))))))))).))).(...(((((((............(((..((((....))))..))).....))))))).(....)..)..))))))....((((((((.......))))))))......))...))))))).(......)...)))))..((((.((..(.(((((.((.(((..(.((..(...(((.((..(...(((((....)))).)..)..)).)))..)..)).)..))).)).))))))..)).))))....((((.(((....))).)))) Cryo-EM structure of the 90S pre-ribosome from Saccharomyces cerevisiae, state A (Poly-Ala); 18S rRNA 6zqa D4 175 4.4 RF01846 URS00021ED97C_559292 32943521 0006396 0005730 559292 gucgacguacuucauaggaucauuucuauaggaaucgucacucuuugacucuucaaaagagccacugaauccaacuugguugaugagucccauaaccuuuguacccgugagaaagugccguugcuauggcgcgaugaucuacccauggguggguacaaauggcagucugacaagu .........................................................................<<<<<......<..........<<<<<<<<<<.....<.....<<<<<....>>>>>.>........<<<<..>>>>.>>>>>>>>.>>....>...>>>>> .........................................................................(((((......(..........((((((((((.(...(.....(((.(....).))).)......).((((..)))).)))))))).))....)...))))) Cryo-EM structure of the 90S pre-ribosome from Saccharomyces cerevisiae, state A (Poly-Ala); U3 snoRNA 6zqb D2 522 3.9 URS000007769E_559292 32943521 559292 ugcgaaagcaguugaagacaagugcuugucguucguuaaaauggccucgucaaacgguggagagagucgcuaggugaucgucagaucugccuagucucuauacagcguguuuaauugacauggguugaugcguauugagagauacaauuugggaagaaauucccagaguguguuucuuuugcguuuaaccugaacagucucaucgugggcaucuugcgauuccauuggugagcagcgaaggauuugguggauuacuagcuaauagcaaucuauuucaaagaauucaaacuugggggaaugccuuguugaauagccggucgcaagacugugauucuucaaguguaaccuccucucaaaucagcgauaucaaacguaccccgugaaacaccgggguaucuguuugguggaaccugauuagaggaaacucaaagagugcuaugguauggugacggagugcgcuggucaagaguguaaaagcuuuuugaacagagagcauuuccggcagcagagauuucagcuguu <<<....>>>...<<<<<<<<<..>>>>>>.>>>..............<<<<<<<<.<<...<<<<..<<<<<<<<<<<....>>>>.>>>>>>>>>>>...>>.>>>......>>>>>..<<<<<...<<<<<..<<<<<.<<<<.<<<<<<<<....>>>>>>>>.>>>>.>>>>>.>>>>>..>>>>>.......<<<<<<<<<<<...........>>>>>.>>>>>>.........................<<<...>>>.........................<<<<<..<<<<<<<..<<<....<<<<<....>>>>>...>>>..>>>>.>>.>>>>>>.....<<<<<<....<<<<<<<.<<<<<<<........>>>>>>>...>>>>>>>.....>>>>>>.................................<<<<<<<<.<<<.<<<<<<<<......>>>>.>>>>.>>>...>>>>.>>>><<<<<.<<<..>>>.>>>>>. (((....)))...(((((((((())))))).)))..............((((((((.((....(((..(((((((((((....)))).))))))))))....)).)))......)))))..((((.....((.(..((((((((((.((((((((....)))))))).)))))))))).).))....)))).....(.((((((.(((((.....)....))))..)))))))........................(((...))).........................(((((..(((((((..((.(..((((((....))))).)).))..)))).)).)))))).....((((((.....(((((((((((((((.....).))))))).).))))))......)))))).................................((((.(((.(((.((((((((......)))).)))).)))...)))..))))(.(((.((....)).))).). Cryo-EM structure of the 90S pre-ribosome from Saccharomyces cerevisiae, state B2; 5ETS RNA 6zqb D3 1198 3.9 RF01960,RF01959,RF00177 URS00021ED968_559292 32943521 0003735 0005840 559292 aagauaguuaucugguugauccugccagucauaugcuugucucagccaugcagucuaaguauaagcaauuuauacagugaaacugcgaaugcucauuaaaucaguuaucguuuauuugauagucaugguauaacugugguaauucuagagcuaaaaucucgacccuuuggaagagauguauuuauuagaucaaugucuucggacucuuugaugaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaagggcaggcuuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauugcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgaggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggaaacucaccagguccagacacaauauuugugggugguggugcaugugaugcccuuguucuggcgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaaaacuccgucggggaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccucucagagcggagauuuggacaaacuuggucauuuagaggaacuaaguuuccguaggugaaccugcgga ..............................<<<<<<...<....<<<.<<<.<<....<.....<............>....>.>>.....<<<.......<<<..<<..<<....<<<..............<<.<<<.....>>>.>>.....<<<<<..<......>..>>>>>....<<<<...<<<<<.<<<....>>>...>>>>>..>>>>.........<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<.....<<<<<<<<.......>>>>>>>>.>>......>>>.....<<...............>>..>>>.<<.<<<..........>>>.>>.<.<<....>>.>.>>>>>>..<<<....<<<.....>>>..>>>.........>.....<<<<<<<.<<<<<....>>>>>.>>>.>>>>......<<..<...........>..>>.........<<<<<<.......<<<....>>>..................>>>>>>..>>>>>>...<.<<...<<<.<<.....<<<<<.<<<<<............>>>>>.>>>>>....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>............<<...<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>..>>..................<<.........>>.....<<<<<<<<<<<<..<<.<<<<<<..<<<.<<<<........<<<<..<....<<<<<...>>>>>......<<<<.......>>>>...>..>>>>>>>>.>>>.....<<<<<<<............<<<..<<<<....>>>>..>>>.....>>>>>>>............>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>............>>>>>..<<<<.<<....<<<<<<<<.<<.....<<......<<<<<<<.<<<<.<.<......>.>>>>>.>>>>>>>.....>>.....>>.>>>>>>>>...>>.>>>>....<<<<<<<<....>>>>>>>> ............................(.(((((.(..(....(((..((.((....((....((..........))...))[)).....(((.......(((..(...((....(((..............((.(((.....))).)).....(((.(..((....))..).)))(.(.((((...(((((.(((....)))...)))))..)))).)...).(.((((..((((..).))).)))))...)))...)).)..))).(((....(((....((((((((.......)))))))))))......))).....((...(........)..))..))).((.(((..........))).)).(.((....)).).)).)))..(((...((((.]...))).)))).........).....(((((((.(((((....))))).))).))))....(.((..(...........)..))......)..((((((.......(((....)))..................))))))..)))))))..(.((...(((.((.....((.((.(((((............))))).).)))....))...(((.(((.((...((((..((..(((.((.....((........))........)).)))..)).......((....))...))))..)).)))..))..))))...)).).............(...(((..((((((((.(((........)))))))))))..)))..)...................((.........)).....((((((.(((((..((..(((((..((((.(((........((((..(....(((((...)))))....(.(((((....).)))))..)..)))))))).))).(...(((((((............(((..((((....))))..))).....))))))).(....)..)..))))).....((((((((.......))))))))......))...))))).).(......)...)))))..((((.((..(.((((((((.(((..(.((..(...((((((..(..((((.(....).))).))..))))))..)..)).)..))).)))))))))..)).))))....((((.((......)).)))) Cryo-EM structure of the 90S pre-ribosome from Saccharomyces cerevisiae, state B2; 18S rRNA 6zqb D4 175 3.9 RF01846 URS00021ED97C_559292 32943521 0006396 0005730 559292 gucgacguacuucauaggaucauuucuauaggaaucgucacucuuugacucuucaaaagagccacugaauccaacuugguugaugagucccauaaccuuuguacccgugagaaagugccguugcuauggcgcgaugaucuacccauggguggguacaaauggcagucugacaagu .........................................................................<<<<<.................<<<<<<<.<<.....<.....<<<........>>>.>........<<<....>>>.>>.>>>>>.>>........>>>>> .........................................................................(((((......(..........(((((((..(.(...(.....(((((....))))).)......).((((..)))).)..))))).))....)...))))) Cryo-EM structure of the 90S pre-ribosome from Saccharomyces cerevisiae, state B2; U3 snoRNA 6zqc D2 446 3.8 URS000007769E_559292 32943521 559292 augcgaaagcaguugaagacaagugcuugucguucguuaaaauggccucgucaaacgguggagagagucgcuaggugaucgucagaucugccuagucucuauacagcguguuuaauugacauggguugaugcguauugagagauacaauuugggaagaaauucccagaguguguuucuuuugcguuuaaccugaacagucucaucgugggcaucuugcgauuccauuggugagcagcgaaggauuugguggauuacuagcuaauagcaaucuauuucaaagaauucaaacuugggggaaugccuuguugaauagccggucgcaagacugugauucuucaaguguaaccuccucucaaaucagcgauaucaaacguaccccgugaaacaccgggguaucuguuugguggaaccugauuagaggaaacucaaagagugcuaugguaug .<<<....>>>...<<<<<<<<<..>>>>>>.>>>..............<<<<<<<<.<<...<<<<..<<<<<<<<<<<....>>>>.>>>>>>>>>>>...>>.>>>......>>>>>..<<<<<...<<<<<..<<<<<<<<<<.<<<<<<<<....>>>>>>>>.>>>>>>>>>>.>>>>>..>>>>>.......<<<<<<<<<<<...........>>>>>.>>>>>>.........................<<<...>>>.........................<<<<<..<<<<<<<..<<<<...<<<<<....>>>>>.>.>>>..>>>>.>>.>>>>>>.....<<<<<<...<<<<<<<<<<<<<<<<........>>>>>>>.>.>>>>>>>>....>>>>>>............................. .(((....)))...(((((((((..)))))).)))..............((((((((.(((..((((..(((((((((((....)))).))))))))))).).)).)))......)))))..(((((....((((...(((.(.(((.((((((((....)))))))).))).).)))..))))...))))).....(.((((((((((((.....)....))))).)))))))........................(((...))).........................(((((..(((((((..((((..((((((....))))).)))))..)))).)).)))))).....((((((....((((((((((((((((.....).))))))).).))))))).....))))))............................. Cryo-EM structure of the 90S pre-ribosome from Saccharomyces cerevisiae, state Pre-A1; 5ETS RNA 6zqc D3 1327 3.8 RF01960,RF01959,RF00177 URS00021ED968_559292 32943521 0003735 0005840 559292 aagauaguuaucugguugauccugccagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauagcaugguauaacugugguaauucuagagcuaauacaugcuaucucgacccuuuggaagagauuauuuauuagauucuucggacucuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauugcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgauauauuagcauggaauaauaggacguuugguucuauuuuguugguuucuaggaccaucguaauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgaggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggaaacucaccagguccagacacaauauuugugggugguggugcaugugaugcccuuguucuggcgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaaaacuccgucggggaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggaaauuuggacaaacuuggucauuuagaggaacuaaguuuccguaggugaaccugcgga ...........................<<.<<<<<<...<.<..........<<<.<<<..<<....<<....<<..........>>...>>.>>......<<..<.....<<<..<<..<<....<<<.......<<....<<.<<<.....>>>.>>.....>>.....<<<<<..<<....>>..>>>>>...<<<<<<...<<....>>....<<......>>>>>>>>.........<<<<.<<<<.....>>>>>>>>....>>>...>>>>..>>>.<<<....<<......<<<<<<<.......>>>>>>>..>>......>>>...<<<<<<<<....>>>>...>>>>>>>.<<.<<<<........>>>>.>>.<.<<<..>>>.>...>>>>>>.........<<<....<<<.....>>>..>>>.......>.>.....<<<<<<<.<<<<<....>>>>>.>>>.>>>>......<<..<...........>..>>.........<<<<<<.......<<<....>>>..................>>>>>>..>>>>>>>>.<.<<...<<<.<<....<<<<<<.<<<<<............>>>>>.>>>>>>..<<<<<.<<......<....<<.......>>..<<.....>>.....>......>>.>>..>>>....<<<...<<<<<<...............>>>>>>..>>>..>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>..>.>>>>.>>>...>>>...>>.>..........<<...<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>..>>..................<<.........>>.....<<<<<<<<<<<<..<<.<<<<<<..<<<.<<<<........<<<<<.<....<<<<<...>>>>>......<<<.<<..>>..>>>...>.>>>>>>>>>.>>>.....<<<<<<<............<<<..<<<<....>>>>..>>>.....>>>>>>>............>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>............>>>>>..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<...<<.<.<......>.>.>>...>>>>>>>..>..>>.>..>>>.>>>>>>>>...>>.>>>>....<<<<<<<<....>>>>>>>> ..........................(((.((((((...(.(...(......(((.(((..((....((....((..........))...))[))......(((.......(((..((..((....(((.......((....((.(.(.....).).)).....)).....(((((..((....))..))))).(.((((((...((....))....((......)))))))).).....(.((((...(((..).))..)))))...)))...))))..))).((...(.(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.((((........)))).)).(.((....)).)...)))))).......(.(((...((((.]...))).))))).)....).).....(((((((.(((((....))))).))).))))....(.(((.(...........)).))......)..((((((.(.....(((....)))...............)..))))))..)))))))))(.((....((.((.....(((((.(((((.....().....))))).)))))...(((((.((......(.(..((.......))..((.....))....))......)).))..))).....((..(.((.(((.............))).)).).))...))...(((.(((.((...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)).)))..))..)))....)).)..........((...(((..((((((((.(((........)))))))))))..)))..))..................((.........)).....((((((((((((..((..(((((..((((.(((........(((((.(....(((((...)))))....(.((..((..))...)))..).))))))))).))).(...(((((((............(((..((((....))))..))).....))))))).(....)..)..))))).....((((((((.......))))))))......))...))))))).(......)...)))))..((((.((..(.((((((((.(((..(.((..(...((((((..(...(.(((....).)).)..)..))))))..)..)).)..))).)))))))))..)).))))....((((.(((....))).)))) Cryo-EM structure of the 90S pre-ribosome from Saccharomyces cerevisiae, state Pre-A1; 18S rRNA 6zqc D4 230 3.8 RF01846 URS00021ED8E9_559292 32943521 0006396 0005730 559292 gucgacguacuucauaggaucauuucuauaggaaucgucacucuuugacucuucaaaagagccacugaauccaacuugguugaugagucccauaaccuuuguacccgugagaaauagcuugguccgcaauccuuagcgguucggccaucuauaauuuugaauaaaaauugugccguugcuauggcgcgaugaucuacccauggguggguacaaauggcagucugacaagu .........................................................................<<<<<.................<<<<<<<<<<.<...<...<<<..<<<.<<<.<<<<......>>>>>>>>>>.>>>.<<<<<......>>.>>>..<<<<<....>>>>>.>......>.<<<<..>>>>.>>>>>>>>.>>........>>>>> .........................................................................(((((......(..........((((((((((.(...(...(((..(((.(((.((.(......).)))))))).))).((((.(....).).)))..(((((....))))).)......).((((..)))).)))))))).))....)...))))) Cryo-EM structure of the 90S pre-ribosome from Saccharomyces cerevisiae, state Pre-A1; U3 snoRNA 6zqd D2 81 3.8 URS00021ED8F1_559292 32943521 559292 ugcgaaagcaguugaagacaagugcuugucguucguuaaaauggccucgucggauuugguggaaggaaacucaaagagugc <<<....>>>...<<<<<<<<<..>>>>>>.>>>............................................... (((....)))...(((((((((..)))))).)))............................................... Cryo-EM structure of the 90S pre-ribosome from Saccharomyces cerevisiae, state Post-A1; 5ETS RNA 6zqd D3 1409 3.8 RF01960,RF01959,RF00177 URS00021ED995_559292 32943521 0003735 0005840 559292 ucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuacaugguauaacugugguaauucuagagcuaauacaugcuaucucgacccuuuggaagagauguauuuauuagauaucuucggacugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuguuguugcaguuaaaaagcucguaguugaacuggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaguuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgauauauuagcauggaauaauaguaggagguucuauucuaggaccaucguauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucugggggaguauggucgcaaggcuaaaaaaggaauugacggaagggcaccaccaggaguggagccugcggcgcgcuacacugacggagccagcgagaccuuggccgagaggucuugggaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagauuuggacaaacuuggucauuugaggaacuaauuccguaggugaaccugcggaaggaucauuaaa .<<<<<.......>>>>>.....<<<<<<...<.<..........<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<..<<..<<....<<<..............<<....<<.<<.......>>.>>.....>>.....<<<<<..<<....>>..>>>>><...<<<<<<....<<....>>.<<......>>>>>>>>.....>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<<..>>>.>...>>>>>>.........<<<....<<<.....>>>..>>>.......>.>.....<<<<<<<.<<<<<....>>>>>.>>>.>>>>......<<..<...........>..>>.........<<<<<<.......<<<....>>>..................>>>>>>..>>>>>>..........<<<((.....<.<<...<<<.<<..<<<<<.<<<<<.....<>.....>>>>>.>>>>>..<<<<.<<<<.<..<<..<<<<<.....>>>>>..>>..>.>>>><<<<<.<<.......<<..<<.......>>.<<<.....>>>...>>......>>.>>..>>>....>>>>.<<.<<<...>>>.>>.......>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<..(...>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<....<...<<<<..)......>>>>...>.>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..))>>...>>.....>>>.>>>.................................<<<<<<<<<<<<..<<.<<<<<<..<<<.<<<.>>>.>>>.....<<<<<<<.........<<..<<<<....>>>>..>>....>>>>>>>...........<<<<<<.<<....>>.>>>>>>..........>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>............>>>>>..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<.<<<<.<<<......>>>.>>>>.>>>>>>>..>..>>.>..>>>.>>>>>>>>..>>.>>>>.<<<<<<<<<....>>>>>>>>>........... .((((.........))))...(.((((((...(.(...(......(((.(((..((....((....((..........))...))[))......(((.......(((..((..((....(((..............((....((.(((.....))).)).....)).....(((((..((....))..)))))(.(.((((((.....(....)..((......)))))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).......(.(((...((((.]...))).))))).)....).).....(((((((((((((....))))))))).))))......(((.(...........)).)).........(((((((......(((....)))...............)..))))))..))))))).........((({....(.(.((...(((.((..(((((.(((((.....().....))))).)))))..((((.((((.(..((..(((.(.....).)))..))..).))))(((((.((.......((..((.......))..((.....))....))......)).))..)))....)))).((.(((...))).)).......))...(((.(((.((...((((..(((.((((((.....((...[....))........)))))).))).......((....))...))))..)).)))..))..))))...)).)....((((((....(...((.(..]......).))...).))))))......[....((.((.(((..((((((((.(((........)))))))))))..)))...((..}.))...)).....)).)))).................................((((((((((((..((.((((((..(((.(((.))).))).(...(((((((.........((..((((....))))..))....)))))))......(....((((((.(......).))))))....)..)..))))))....((((((((.......))))))))......))...))))))).(......)...)))))..((((.((....((((((((.(((..(.((..(...((((((......(((((....)))).).....))))))..)..)).)..))).))))))))..)).)))).(((((((((....)))))))))].......... Cryo-EM structure of the 90S pre-ribosome from Saccharomyces cerevisiae, state Post-A1; 18S rRNA 6zqd D4 223 3.8 RF01846 URS00021ED8E9_559292 32943521 0006396 0005730 559292 gucgacguacuucaaggaucaucuauaggaaucgucacucuuugacucuucccacugaauccaacuugguugaugagucccauaaccuuuguaccccagagugagaaauagcuugguccgcaauccuuagcgguucggccaucuauaauuuugaauaaaaauugugccguugcuauggcgcgaugaucacccauggguggguacaaauggcagucugacaagu ...............................................................<<<<<.................<<<<<<<<<<<....<........<<..<<<.<<<.<<<<......>>>>>>>>>>.>>..<<<<<<....>>>.>>>..<<<<......>>>>........><<<<..>>>>>>>>>>>>>.>>........>>>>> ...............................................................(((((......(..........(((((((((((....(...(....((..(((.(((.((((......)))))))))).))..((((((....))).)))..(((((....))))).)......)((((..))))))))))))).))....)...))))) Cryo-EM structure of the 90S pre-ribosome from Saccharomyces cerevisiae, state Post-A1; U3 snoRNA 6zqe D2 81 7.1 URS00021ED8F1_559292 32943521 559292 ugcgaaagcaguugaagacaagugcuugucguucguuaaaauggccucgucggauuugguggaaggaaacucaaagagugc <<<....>>>...<<<<<<<<<..>>>>>>.>>>............................................... (((....)))...(((((((((..)))))).)))............................................... Cryo-EM structure of the 90S pre-ribosome from Saccharomyces cerevisiae, state Dis-A (Poly-Ala); 5ETS RNA 6zqe D3 1447 7.1 RF01960,RF01959,RF00177 URS00021ED995_559292 32943521 0003735 0005840 559292 ucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauagucaugguauaacugugguaauucuagagcuaauacaugcuaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucugggggaguauggucgcaaggcuaaaaaaggaauugacggaagggcaccaccaggaguggagccugcggcgcgcuacacugacggagccagcgagaccuuggccgagaggucuugggaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagauuuggacaaacuuggucauuuaggaacuaauuccguaggugaaccugcggaaggaucauuaaa .<<<<<.......>>>>>.....((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[........<<....<<.<<<.....>>>.>>.....>>.....<<<<<..<<....>>..>>>>>[...((((((......<<<<<<<.<<<....>>>....<<......>>)))))).....]...<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<<<.<<<<<....>>>>>.>>>.>>>>......<<..<...........>..>>.........<<<<<<.......<<<....>>>..................>>>>>>..))))))..........[[[<<.......{{...[[[.[[....<<<<<<.<<<<<............>>>>>.>>>>>>....<<<<<<........<<<<.......>>>>........>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........[[...[.(((((......>>>>>>>..))))).]..]].....]]....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>..>>.>>>.>>>...]]]...}}......<<<<<<<...<...<<<...........>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..>>>>...>>.....>>>.]]].................................<<<<<<<<<<<<..<<.<<<<<...<<<.<<<.>>>.>>>.....<<<<<<<.........<<..<<<<....>>>>..>>....>>>>>>>...........<<<<<<..........>>>>>>...........>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>............>>>>>..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<.<<<<.<<<......>>>.>>>>.>>>>>>>..>..>>.>..>>>.>>>>>>>>.>>.>>>>.<<<<<<<<<....>>>>>>>>>........... .((((.........)))).(.(.((((((...(.(...(......(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((........((....((.(.(.....).).)).....)).....(((((..((....))..)))))(.(.((((((......[[[[[[[.(((....))).....(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).......(.(((...((((.}...))).))))).)....).).....(((((((((((((....))))))))).))))......(((.(...........)).)).........(((((((.(....(((....)))..)............)..))))))..))))))))........((({....(.(.((....((.((....((((((.(((.(.....()......)))).))))))......((((....(...(((..(....).)))...)....)))).....(((((.((.......((..((.......))..((.....)).....))......)).))..))).........(....(.((.(((.....]]]]]]].))).).))...).....))...(((.(((..(...((((..(((.((((((.....((...[....))........)))))).))).......((....))...))))..)..)))..))..)))....)).)....((((.(....(...((((..]......))))...).).))))......[....((.((.(((..((((((((.(((........)))))))))))..)))...((..}.))...)).....)).)))).................................((((((((((((..((.((((((..(((.(((.))).))).(...(((((((.........((..(.((....)).)..))....)))))))......(....((((((..........))))))....)..)..))))))....(.((((((.......)))))).)......))...))))))).(......)...)))))..((((.((....(((((.((.(((..(.((..(...((((((.......((((....)))).......))))))..)..)).)..))).)).))))).)).)))).(((((.(((....))).)))))].......... Cryo-EM structure of the 90S pre-ribosome from Saccharomyces cerevisiae, state Dis-A (Poly-Ala); 18S rRNA 6zqe D4 223 7.1 RF01846 URS00021ED8E9_559292 32943521 0006396 0005730 559292 gucgacguacuucaaggaucaucuauaggaaucgucacucuuugacucuucccacugaauccaacuugguugaugagucccauaaccuuuguaccccagagugagaaauagcuugguccgcaauccuuagcgguucggccaucuauaauuuugaauaaaaauugugccguugcuauggcgcgaugaucacccauggguggguacaaauggcagucugacaagu ...............................................................<<<<<.................<<<<<<<<<<<....<.......<<<..<<<.<<<.<<<<......>>>>>>>>>>.>>>.<<<<<<....>>>.>>>..<<<<......>>>>........><<<<..>>>>>>>>>>>>>.>>........>>>>> ...............................................................(((((......(..........(((((((((((....(...(...(((..(((.(((.((((......)))))))))).))).((((((....))).)))..(((((....))))).)......)((((..))))))))))))).))....)...))))) Cryo-EM structure of the 90S pre-ribosome from Saccharomyces cerevisiae, state Dis-A (Poly-Ala); U3 snoRNA 6zqf D2 20 4.9 URS00021ED98A_559292 32943521 559292 ggauuugguggauuacuagc .................... .................... Cryo-EM structure of the 90S pre-ribosome from Saccharomyces cerevisiae, state Dis-B (Poly-Ala); 5ETS RNA 6zqf D3 1392 4.9 RF01960,RF01959,RF00177 URS00021ED935_559292 32943521 0003735 0005840 559292 uaucugguugauccugccaguucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuauguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcuaaauuaaaggaauugacggaagggcaccaccaggaguggagccugcggcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccggaacuaauuccguaggugaaccugcggaaggaucauuaaaga ...<<<<<.......>>>>>...<<<<<<...<.<..........<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<..<<..<<....<<<..................<.....<<.<<.......>>.>>......>.........<<<<<..<<....>>..>>>>><...<<<<<<.........(((..<<<....>>>..............>>>>>>.....>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>..>>>.......>.>.....<<<<<..<.<..........>.>..>>.>>>......<<..<...........>..>>.........<<<<<<.......<<<....>>>..................>>>>>>..>>>>>>.........<<<.[.....<.<<...<<<.<<....<<<<<<.<<<<<....<..>....>>>>>.>>>>>>....<<<<<<...............................>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........<<...<<<<<<<<......)))....>>>>>>>>..>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>.>.>>......<<<....>>>..>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..].>>...>>.....>>>.>>>....................................<<<<<<<<<<<<..<<..<<<<<..<<<.<<<.....>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>.....<<<<<<<.........>>>>>>>......>>...>>>>>>>............>>>>>..<<<<.<<>>.>>>>.<<<<<<<<<....>>>>>>>>>............. ...((((.........))))...((((((...(.(...(......(((.(((..((....((....((..........))...))[))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((..........{{..(((....))).....(......).)))))).)...).(.((((..(((.....))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).......(.(((...((((.]...))).))))).)....).).....(...(.((....(....)....)).)....)......(((.(...........)).)).........((((((.......(((....)))..................))))))..)))))).........((([[...(.(.((...(((.((....((((((.(((((.....().....))))).))))))....((((((...............................))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(......((.(((......}}.....))).)).....).....))...(((..((.((...((((..((..((((((.....((...[....))........))))))..)).......((....))...))))..)).))...))..))))...)).)....((((((....(...((((..]......))))...).))))))..........(((.((.(((..((((((((.(((........)))))))))))..)))...((..]]))...)).....)))))))....................................((((((((((((..((..(((((..(((.((((...)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...))))))).(......)...)))))..((((.(()).)))).(((((((((....)))))))))............. Cryo-EM structure of the 90S pre-ribosome from Saccharomyces cerevisiae, state Dis-B (Poly-Ala); 18S rRNA 6zqf D4 35 4.9 URS00021ED975_559292 32943521 559292 gucgacguacuucaaggaucagccacugaauccaa ................................... ................................... Cryo-EM structure of the 90S pre-ribosome from Saccharomyces cerevisiae, state Dis-B (Poly-Ala); U3 snoRNA 6zqg D3 1387 3.5 RF01960,RF01959,RF00177 URS00021ED935_559292 32943521 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuauguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcuaaagacggaagggcaccaccaggaguggagccugcggcuuacacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccggaacuaauuccguaggugaaccugcggaaggaucauuaaaga <..<<<<<.......>>>>>.><..<<<<<<...<.<..........<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<..<<..<<....<<<..................<.....<<.<<<.....>>>.>>......>.........<<<<<..<<....>>..>>>>><.<.<<<<<<......((((((..<<<....>>>..............>>>>>>.>...>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>..>>>.......>.>.....<<<<<....................>>.>>>......<<..<...........>..>>.........<<<<<<.......<<<....>>>..................>>>>>>..>>>>>>.>.......<<<[[.....<.<<...<<<.<<....<<<<<<.<<<<<............>>>>>.>>>>>>....<<<<<<.........<<<.......>>>.........>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........<<<....<<<<<.......))))))..>>>>>...>>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<..(...>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<..)......>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..]]>>...>>.....>>>.>>>.........................<<<<<<<<<<<<..<<.<<<<<...<<<.<<<<.......>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>...........>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>............>>>>>..<<<<.<<>>.>>>>.<<<<<<<<<....>>>>>>>>>............. ...(((((.......))))).(...((((((...(.(...(......(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[[[[[[.(((....))).....(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).......(.(((...((((.}...))).))))).)....).).....((......(.(.(....).).).......))....(.(((.(...........)).))......)..(((((((......(((....)))...............)..))))))..))))))..)......((({{...(.(.((...(((.((....((((((.(((((.....().....))))).))))))....(.(..(....(...((((.(....)))))...)....)..).)...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(....(.((.(((.....]]]]]]].))).).))...).....))...(((..((.((...((((..((..((((((.....((...[....))........))))))..)).......((....))...))))..)).))...))..))))...)).)....((((((....(...((((..]......))))...).))))))......[...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...)).....))))))).........................((((((((((((..((.((((((..(((.(((((....).)))).))).(...(((((((......((.....((...(((....)).)..))....)).......)))))))......(....((((((..........))))))....)..)..))))))....(.((((((.......)))))).)......))...))))))).(.......)..)))))..((((..(.).)))).(((((((((....)))))))))]............ Cryo-EM structure of the 90S pre-ribosome from Saccharomyces cerevisiae, state Dis-C; 18S rRNA 6zqg D4 23 3.5 URS00021ED95F_559292 32943521 559292 ngucgacguacuucauaggauca ....................... ....................... Cryo-EM structure of the 90S pre-ribosome from Saccharomyces cerevisiae, state Dis-C; U3 snoRNA 6zs9 XA 1501 4.0 RF02541,RF02540 URS00021ED97A_9606 32812867 0003735 0005840 9606 gcuaaaccuagccccaaacccacuccaccuuacuaccagacaaccuuagccaaaccauuuacccaaauaaaguauaggcgauagaaauugaaaccuggcgcaauagauauaguaccgcaagggaaagaugaaaaauuauaaccaagcauaauauagcaaggacuaaccccuauaccuucugcauaaugaauuaacuagaaauaacuuugcaaggagagccaaagcuaagacccccgaaaccagacgagcuaccuaagaacagcuaaaagagcacacccgucuauguagcaaaauagugggaagauuuauagguagaggcgacaaaccuaccgagccuggugauagcugguuguccaagauagaaucuuaguucaacuuuaaauuugcccacagaacccaaaauccccuuguaaauuuaacuguuaguccaaagaggaacagcucuuuggacacuaggaaaaaaccuuguagagagaguaaaaaauuuaacacccauaguaggccuaaaagcagccaccaauuaagaaagcguucaagcucaacaccaaaaaucccaaacauauaacugaacuccucacacccaauuggaccaaucuaucacccuauagaagaacuaauguuaguauaaguaacaugaaaacauucuccuccgcauaagccugcgucagauaaccaacugacaauuaacagcccaauaucuacaaucaaccaacaagucauuauuacccucacugucaacccaacacaggcaugcucauaaggaaagguuaaaaaaaguaaaaggaacucggcaaaucuuaccccgccuguuuaccaaaaacaucaccucuagcaucaccaguauuagaggcaccgccugcccagugacacauguuuaacggccgcgguacccuaaccgugcaaagguagcauaaucacuuguuccuuaaauagggaccuguaugaauggcuccacgaggguucagcugucucuuacuuuuaaccagugaaauugaccugcccgugaagaggcgggcauaacacagcaagacgagaagacccuauggagcuuuaauuuauuaaugcaaacaguaaccaaaccugcauuaaaaauuucgguuggggcgaccucggagcagaacccaaccuccgagcaguacaugcuaagacuucaccagucaaagcgaaccucaauugauccaauaacuugaccaacggaacaaguuacccuagggauaacagcgcaauccuauucuagaguccauaucaacaauaggguuuacgaccucgauguuggaucaggacaucccgauggugcagccgcuauuaaagguucguuuguucaacgauuaaaguccuacgugaucugaguucagaccggaguaauccaggucgguuucuaucuacuuauuccucccuguacgaaaggacaagagaaauaaggccuacuucacaaagcgccuucccccguaaaugauaucaucucaacuuagaauacccacacccacccaagaacaggguu <<<.......<<<<.....................................<......>.........<.....<<.....>>....>........>>.>>.............<<....>>......................>>>...........<<<.......>>>...<.<........>.>.<<<<<<.........<<<.<<..<<....>>...>>.>>>...<<.<...<<<<.<.....<<<<<.<<<..<<<.....>>>...<<<..<<<<........>>>>.>>>....>>>.>>>>>...<<.......>>......>.>>>>......>.>>..<<<<<<....<<<<....>>>><<<.<<<<<<<<<<.....<<........>>.....>>>>>>>>>>..>>>.<<<<<<<<<<......>>>>>>>>>>...<<<......>>>....<<<.<<<...<..............<....<<<.........>>>....>.......<<<......>>>...........................>...>>>>>>........>>>>>>...<<<<<......>>>>>.........>>>>>><......<<..<<<....>>><<<<..<<<<........<<<<<........>>>>>......<<<...<<<<.......................>>>>.......>>>.....<<......>>.>>>>.....>>>>..<<<<...<<<<<<<<.<<.........<......<<<<<<..<<<.........>>>...<<<<<<.............>>>>>>....<<<.<<<..<<<<<....>>>..>>>>><<<<<<......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>....>>.>>>>.....>..>>.>>>>>>>>>>>>.>>.....>.....<<<<<........>>>>>.......<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<...............>>>>>>>>>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<.....<<<..<<<<.....>>>>..>>>....>>.........<<<....>>>............>>>>..>>>>>>.......<<<..<.<<<<<<...<<.......>>...>>>>>>...>.>>.>.......<<<<<.<<<<<<..<<.<<<<<<......>>>>>>...>>.<<<<.......>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>.<<<.<<<.................>>>.>>><<<<<...<<<....>>>.>>>>>......<<<................>>>..............<<<<.......>>>>. ((.....(..((((.....................................(...[..).........(.....((.]...))....)........)).)).............((....))....)..................)).........(.(((.......))).[.(.(........).).((((((.........(((.((..((....))...)).)))...((.(...((((.(.....(((((.((((.(((....[)))...(((..((((.......{)))).)))..).))).))))).(.((.......))...)..).))))......).))..((((((....((((....)))).((.((((((((((.....((........)).....))))))))))..))..((((((((((......))))))))))...(((......)))....(((.(((...(..............(....(((.........)))....)....(..(((......))))..........................)...))))))........))))))...(((((......))))).........))))))(......((..(((....)))(((...((((......(.(((((........)))))......(((...((((...............(..)....)))).......))).)...((......)).))))......)))..((((....(((((((.((..(....(........((((((.].((.........))....((((((.............))))))....(((.(((..(((((....)))..)))))(((((........)))))........((..........(((((.......)))))..)..)....)))....)).))))....)..))).))))))).)))).)).....)).{..(((((.....]}.))))).......((..(((.((......((((.((((((..(((((.((((((((....(....).....)))))))))))))..(((......[)))((((((..........]))))))(.((.....((...(((....[..)))...))....)).........(((....))).....)].....))))..))))))......((((..(.((((((.(.((.......)))..))))))...).)).).).....(((((.((((((..((.((((((......))))))...)).(((((.....))))).....)))))..)...))).))....(((((((....))).))))..}.))..))).)).(((.(((......(....).....))).)))(((((...(((....))).)))))......(((................)))..............((((.......)))). Human mitochondrial ribosome in complex with ribosome recycling factor; 16S rRNA 6zs9 AA 927 4.0 RF00177 URS00021ED906_9606 32812867 0003735 0005840 9606 auagguuugguccuagccuuucuauuagcucuuaguaagauuacacaugcaagcauccccguuccagugaguucacccucuaaaucgaucaaaaggaacaagcaucaagcacgcagcaaugcagcucaaaacgcuuagccuagccacacccccacgggaaacagcagugauuaaccuuuagcaauaaacgaaaguuuaacuaagcuauacuaaccccaggguuggucaauuucgugccagccaccgcggucacacgauuaacccaagucaauagaccggcguaaagaguguuuuagaucacaauaaagcuaaaacucaccugaguuguaaaaaacuccaguugacacaaaauagacuacgaaaguggcuuuaacauaucugaacacacaauagcuaagacccaaacugggauuagauaccccacuaugcuuagcccuaaaccucaacaguucaacaaaacugcucgccagaacacuacgagccacagcuuaaaacucaaaggaccuggcggugcuucauaucccucuagaggagccuguucuguaaucgauaaaccccgaucaaccucaccaccucuugcucagccuauauaccgccaucuucagcaaacccugaugaaggcuacaaaguaagcgcaaguacccacguaaagacguuaggucaagguguagcccaugagguggcaagaaaugggcuacauuuucuaccccagaaacgauagcccuuaugaacuauaagggucgaagguggauuuagcaguaaacuaagaguagagugcuuaguugaacagggcccugaagcgcguacacaccgcccgucacccuccucaaguauacuucaaaggacuuaacuaaaaccccuacgcauuuauauagaggagacaagucguaacaugguaaguguacuggaaagugcacuuggacgaac ..((((..<<<<<<.)))).<<<<<<.<...<<<<<<<<..<.<<<.<<<..<......>......<<........<<<.<..<<..>>.>..>>>...<<<<....<<...<<<....>>>..>>......>>>>.<<...>>.>>.<<<....>>>.....>>>>>>>........<<<....<<<......>>>..>>>..>>.>>>>>>.....<<<<<<<<.....(((.....((.>>>)).......)))..>>>>>...>.>>>>>>..<<<((.....<<<<..<<<<......<<<<<<......<<<.<<<.<<<......>>>..>>>.>>>.............<<....>>.>>>>>>.....>>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<.<<<<<..))..>>>>>.>.>>>.<<.......<<<<....>>>>.....>>..>>>>>><<<<<.<<<<<<<...<<<.<<<<<..<<<<<<<<<<.....<<........>>..........<<<<<<<.......<<.<<<..<<<<<<.<.....<<..<<<<<.....>>>.......>>..>>.....<<<....>>>.....>...>>>...>>>>>>>>....>>>>>>>..>>.>>>>>>>>.....<<<<.....>>>>.<....<<<<<<<.......>>>>>>>....>.....>>>>>.....<<<<<<<.........>>>>>>>.....>>>...>>>>>>>>>>.>>....<..<<.<...<<<<<<..<<<<<..<...<<<..<<.....>>...>>>....>..>>>>>.>>>>>>....>.>>...>.....<<<<<<<<<....>>>>>>>>>........ [.[[[[..(((((..]]]]]((((((.((...(((((((..(.(((.(((..(......)......(((.......(((.(..((())).)..)))...((((....((..((((....))).)))......)))).((...))))).(((....))).....)))))))......(.(((...(((((....)))).))))).)).)))).).....((((([[[.....(((.....((.]]])).......)))..)))))..)).))))))..((([[...(.((((...(((......(((((((.....(((.(((.(((......)))..))).))).....).....(.((....))))))))).....)))....))))....((((((...((...((((.........))))...))))))))......{...(.(((((..]]..))))).))))).((.......((((....)))).....))...)))))(((((.(((((((...(((.(((((..((((((((((.....((........))..........(((((((.......((.(((...((((((.(....((..(((((.....))).......))..))......((....))......).).)))...)).)))))....)))))))..)).)))))))).(...((((.....)))).(....(((((((.......)))))))....)..)..))))).....(((((((.........))))))).....)))...)))))))))).))..(.(..((.(...((((((..(((((..((..(((..((.....))...)))..).)..))))).))))))....).))...)..)..(((((((((....)))))))))}....... Human mitochondrial ribosome in complex with ribosome recycling factor; 12S rRNA 6zsa XA 1499 4.0 RF02541,RF02540 URS00021ED91E_9606 32812867 0003735 0005840 9606 gcuaaaccuagccccaaacccacuccaccuuacuaccagacaaccuuagccaaaccauuuacccaaauaaaguauaggcgauagaaauugaaaccuggcgcaauagauauaguaccgcaagggaaagaugaaaaauuauaaccaagcauaauauagcaaggacuaaccccuauaccuucugcauaaugaauuaacuagaaauaacuuugcaaggagagccaaagcuaagacccccgaaaccagacgagcuaccuaagaacagcuaaaagagcacacccgucuauguagcaaaauagugggaagauuuauagguagaggcgacaaaccuaccgagccuggugauagcugguuguccaagauagaaucuuaguucaacuuuaaauuugcccacagaacccaaauccccuuguaaauuuaacuguuaguccaaagaggaacagcucuuuggacacuaggaaaaaaccuuguagagagaguaaaaaauuuaacacccauaguaggccuaaaagcagccaccaauuaagaaagcguucaagcucaacaccaaaaaucccaaacauauaacugaacuccucacacccaauuggaccaaucuaucacccuauagaagaacuaauguuaguauaaguaacaugaaaacauucuccuccgcauaagccugcgucagauaacaacugacaauuaacagcccaauaucuacaaucaaccaacaagucauuauuacccucacugucaacccaacacaggcaugcucauaaggaaagguuaaaaaaaguaaaaggaacucggcaaaucuuaccccgccuguuuaccaaaaacaucaccucuagcaucaccaguauuagaggcaccgccugcccagugacacauguuuaacggccgcgguacccuaaccgugcaaagguagcauaaucacuuguuccuuaaauagggaccuguaugaauggcuccacgaggguucagcugucucuuacuuuuaaccagugaaauugaccugcccgugaagaggcgggcauaacacagcaagacgagaagacccuauggagcuuuaauuuauuaaugcaaacaguaaccaaaccugcauuaaaaauuucgguuggggcgaccucggagcagaacccaaccuccgagcaguacaugcuaagacuucaccagucaaagcgaaccucaauugauccaauaacuugaccaacggaacaaguuacccuagggauaacagcgcaauccuauucuagaguccauaucaacaauaggguuuacgaccucgauguuggaucaggacaucccgauggugcagccgcuauuaaagguucguuuguucaacgauuaaaguccuacgugaucugaguucagaccggaguaauccaggucgguuucuaucuacuuauuccucccuguacgaaaggacaagagaaauaaggccuacuucacaaagcgccuucccccguaaaugauaucaucucaacuuagaauacccacacccacccaagaacaggguu <<<.......<<<<.....................................<......>.........<.....<<.....>>....>........>>.>>.............<<....>>......................>>>...........<<<.......>>>...<.<........>.>.<<<<<<.........<<<.<<..<<....>>...>>.>>>...<<.<..<<<<<.<.....<<<<<.<<<..<<<.....>>>...<<<..<<<<........>>>>.>>>....>>>.>>>>>...<<.......>>......>.>>>>...>..>.>>..<<<<<<....<<<<....>>>><<<.<<<<<<<<<<.....<<.......>>.....>>>>>>>>>>..>>>.<<<<<<<<<<......>>>>>>>>>>.<.<<<......>>>.>..<<<.<<<...<..............<....<<<.........>>>....>.......<<<......>>>...........................>...>>>>>>........>>>>>>...<<<<<......>>>>>.........>>>>>><......<<..<<<....>>><<<<..<<<<........<<<<<.......>>>>>......<<<...<<<<.......................>>>>.......>>>.....<<......>>.>>>>.....>>>>..<<<<...<<<<<<<<.<<.........<......<<<<<<..<<<.........>>>...<<<<<<.............>>>>>>....<<<.<<<..<<<<<....>>>..>>>>><<<<<<......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>....>>.>>>>.....>..>>.>>>>>>>>>>>>.>>.....>.....<<<<<........>>>>>.......<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<...............>>>>>>>>>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<.....<<<..<<<<.....>>>>..>>>....>>.........<<<....>>>............>>>>..>>>>>>.......<<<..<.<<<<<<...<<.......>>...>>>>>>...>.>>.>.......<<<<<.<<<<<<..<<.<<<<<<......>>>>>>...>>.<<<<.......>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>.<<<.<<<.................>>>.>>><<<<<...<<<....>>>.>>>>>......<<<................>>>..............<<<<.......>>>>. ((.....(..((((.....................................(...[..).........(.....((.]...))....)........)).)).............((....))....)..................)).........(.(((.......))).[.(.(........).).((((((.........(((.((..((....))...)).)))...((.(...((((.(.....(((((.((((.(((....[)))...(((..((((.......{)))).)))..).))).))))).(.((.......))...)..).))))......).))..((((((....((((....)))).((.((((((((((.....((.......)).....))))))))))..))..((((((((((......))))))))))...(((......)))....(((.(((...(..............(....(((.........)))....)....(..(((......))))..........................)...))))))........))))))...(((((......))))).........))))))(......((..(((....)))(((...((((......(.(((((.......)))))......(((...((((...............(..)....)))).......))).)...((......)).))))......)))..((((....(((((((.((..(....(........((((((.].((.........))....((((((.............))))))....(((.(((..(((((....)))..)))))(((((........)))))........((..........(((((.......)))))..)..)....)))....)).))))....)..))).))))))).)))).)).....)).{..(((((.....]}.))))).......((..(((.((......((((.((((((..(((((.((((((((...............)))))))))))))..(((......[)))((((((..........]))))))(.((.....((...(((....[..)))...))....)).........(((....))).....)].....))))..))))))......((((..(.((((((.(.((.......)))..))))))...).)).).)......((((.((((((..((.((((((......))))))...)).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..}.))..))).)).(((.(((......(....).....))).)))(((((...(((....))).)))))......(((................)))..............((((.......)))). Human mitochondrial ribosome bound to mRNA, A-site tRNA and P-site tRNA; 16S mitochondrial rRNA 6zsa AA 924 4.0 RF00177 URS000044DFF6_9606 32812867 0003735 0005840 9606 auagguuugguccuagccuuucuauuagcucuuaguaagauuacacaugcaagcauccccguuccagugaguucacccucuaaaucgaucaaaaggaacaagcaucaagcacgcagcaaugcagcucaaaacgcuuagccuagccacacccccacgggaaacagcagugauuaaccuuuagcaauaaacgaaaguuuaacuaagcuauacuaaccccaggguuggucaauuucgugccagccaccgcggucacacgauuaacccaagucaauagaccggcguaaagaguguuuuagaucacaauaaagcuaaaacucaccugaguuguaaaaaacuccaguugacacaaaauagacuacgaaaguggcuuuaacauaucugaacacacaauagcuaagacccaaacugggauuagauaccccacuaugcuuagcccuaaaccucaacaguucaacaaaacugcucgccagaacacuacgagccacagcuuaaaacucaaaggaccuggcggugcuucauaucccucuagaggagccuguucuguaaucgauaaaccccgaucaaccucaccaccucuugcucagccuauauaccgccaucuucagcaaacccugaugaaggcuacaaaguaagcgcaaguacccacguaaagacguuaggucaagguguagcccaugagguggcaagaaaugggcuacauuuucuaccccagaaacgauagcccuuaugaauaagggucgaagguggauuuagcaguaaacuaagaguagagugcuuaguugaacagggcccugaagcgcguacacaccgcccgucacccuccucaaguauacuucaaaggacuuaacuaaaaccccuacgcauuuauauagaggagacaagucguaacaugguaaguguacuggaaagugcacuuggacgaac ..((((..<<<<<<.)))).<<<<<<.<<..<<<<<<<<..<.<<<.<<<..<......>......<<........<<<.<..<<..>>.>..>>>...<<<<....<<...<<<....>>>..>>......>>>>.<<...>>.>>.<<<....>>>.....>>>>>>>........<<<....<<<......>>>..>>>..>>.>>>>>>.....<<<<<<<<.....(((.....((.>>>)).......)))..>>>>>..>>.>>>>>>..<<<((.....<<<<..<<<<......<<<<<<......<<<.<<<.<<<......>>>..>>>.>>>............<<<....>>>>>>>>>.....>>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<.<<<<<..))..>>>>>.>.>>>.<<.......<<<<....>>>>.....>>..>>>>>><<<<<.<<<<<<<...<<<.<<<<<..<<<<<<<<<<.....<<........>>..........<<<<<<<.......<<.<<<..<<<<<<.<.....<<..<<<<<.....>>>.......>>..>>.....<<<....>>>.....>...>>>...>>>>>>>>....>>>>>>>..>>.>>>>>>>>.....<<<<.....>>>>.<....<<<<<<<....>>>>>>>....>.....>>>>>.....<<<<<<<.........>>>>>>>.....>>>...>>>>>>>>>>.>>....<..<<.<...<<<<<<..<<<<<..<...<<<..<<.....>>...>>>....>..>>>>>.>>>>>>....>.>>...>.....<<<<<<<<<....>>>>>>>>>........ [.[[[[..(((((..]]]]]((((((.((...(((((((....(((.(((..(......)......(((.......(((.(..((())).)..)))...((((....((..((((....))).)))......)))).((...))))).(((....))).....)))))).......(.(((...(((((....)))).))))).)).)))).).....((((([[[.....(((.....((.]]])).......)))..)))))..)).))))))..((([[...(.((((...(((......(((((((.....(((.(((.(((......)))..))).))).....).....(.((....))))))))).....)))....))))....((((((...((...((((.........))))...))))))))......{...(.(((((..]]..))))).))))).((.......((((....)))).....))...)))))((.((.(((((((...(((.(((((..((((((((((.....((........))..........(((((((.......((.(((...((((((.(....((..(((((.....))).......))..))......((....))......).).)))...)).)))))....)))))))..)).)))))))).(...((((.....)))).(....(((((((....)))))))....)..)..))))).....(((((((.........))))))).....)))...)))))))))..))..(.(..((.(...((((((..(((((..((..(((..((.....))...)))..).)..))))).))))))....).))...)..)..(((((((((....)))))))))}....... Human mitochondrial ribosome bound to mRNA, A-site tRNA and P-site tRNA; 12S mitochondrial rRNA 6zsb XA 1499 4.5 RF02541,RF02540 URS00021ED931_9606 32812867 0003735 0005840 9606 gcuaaaccuagccccaaacccacuccaccuuacuaccagacaaccuuagccaaaccauuuacccaaauaaaguauaggcgauagaaauugaaaccuggcgcaauagauauaguaccgcaagggaaagaugaaaaauuauaaccaagcauaauauagcaaggacuaaccccuauaccuucugcauaaugaauuaacuagaaauaacuuugcaaggagagccaaagcuaagacccccgaaaccagacgagcuaccuaagaacagcuaaaagagcacacccgucuauguagcaaaauagugggaagauuuauagguagaggcgacaaaccuaccgagccuggugauagcugguuguccaagauagaaucuuaguucaacuuuaaauuugcccacagaacccaaauccccuuguaaauuuaacuguuaguccaaagaggaacagcucuuuggacacuaggaaaaaaccuuguagagagaguaaaaaauuuaacacccauaguaggccuaaaagcagccaccaauuaagaaagcguucaagcucaacaccaaaaaucccaaacauauaacugaacuccucacacccaauuggaccaaucuaucacccuauagaagaacuaauguuaguauaaguaacaugaaaacauucuccuccgcauaagccugcgucagauaacaacugacaauuaacagcccaauaucuacaaucaaccaacaagucauuauuacccucacugucaacccaacacaggcaugcucauaaggaaagguuaaaaaaaguaaaaggaacucggcaaaucuuaccccgccuguuuaccaaaaacaucaccucuagcaucaccaguauuagaggcaccgccugcccagugacacauguuuaacggccgcgguacccuaaccgugcaaagguagcauaaucacuuguuccuuaaauagggaccuguaugaauggcuccacgaggguucagcugucucuuacuuuuaaccagugaaauugaccugcccgugaagaggcgggcauaacacagcaagacgagaagacccuauggagcuuuaauuuauuaaugcaaacaguaaccaaaccugcauuaaaaauuucgguuggggcgaccucggagcagaacccaaccuccgagcaguacaugcuaagacuucaccagucaaagcgaaccucaauugauccaauaacuugaccaacggaacaaguuacccuagggauaacagcgcaauccuauucuagaguccauaucaacaauaggguuuacgaccucgauguuggaucaggacaucccgauggugcagccgcuauuaaagguucguuuguucaacgauuaaaguccuacgugaucugaguucagaccggaguaauccaggucgguuucuaucuacuuauuccucccuguacgaaaggacaagagaaauaaggccuacuucacaaagcgccuucccccguaaaugauaucaucucaacuuagaauacccacacccacccaagaacaggguu <<<.......<<<<.....................................<<....>>.........<.....<<.....>>....>........>>.>>.............<<....>>......................>>>...........<<<.......>>>...<.<........>.>.<<<<<<.........<<<.<<..<<....>>...>>.>>>...<<.<..<<<<<.<.....<<<<<.<<<..<<<.....>>>...<<<..<<<<........>>>>.>>>....>>>.>>>>>...<<.......>>......>.>>>>...>..>.>>..<<<<<<....<<<<....>>>><<<.<<<<<<<<<<.....<<.......>>.....>>>>>>>>>>..>>>.<<<<<<<<<<......>>>>>>>>>>...<<<......>>>....<<<.<<<...<..............<....<<<.........>>>....>.......<<<......>>>...........................>...>>>>>>........>>>>>>...<<<<<......>>>>>.........>>>>>><......<<..<<<....>>><<<<..<<<<........<<<<<.......>>>>>......<<<...<<<<.......................>>>>.......>>>.....<<......>>.>>>>.....>>>>..<<<<...<<<<<<<<.<<.........<......<<<<<<..<<<.........>>>...<<<<<<.............>>>>>>....<<<.<<<..<<<<<....>>>..>>>>><<<<<<......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>....>>.>>>>.....>..>>.>>>>>>>>>>>>.>>.....>.....<<<<<........>>>>>.......<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<...............>>>>>>>>>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<.....<<<..<<<<.....>>>>..>>>....>>.........<<<....>>>............>>>>..>>>>>>.......<<<..<.<<<<<<...<<.......>>...>>>>>>...>.>>.>.......<<<<<.<<<<<<..<<.<<<<<<......>>>>>>...>>.<<<<.......>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>.<<<.<<<.................>>>.>>><<<<<...<<<....>>>.>>>>>......<<<................>>>..............<<<<.......>>>>. ((.....(..((((.....................................(...[..).........(.....((.]...))....)........)).)).............((....))....)..................)).........(.(((.......))).[.(.(........).).((((((.........(((.((..((....))...)).)))...((.(...((((.(.....(((((.((((.(((....[)))...(((..((((.......{)))).)))..).))).))))).(.((.......))...)..).))))......).))..((((((....((((....)))).((.((((((((((.....((.......)).....))))))))))..))..((((((((((......))))))))))...(((......)))....(((.(((...(..............(....(((.........)))....)....(..(((......))))..........................)...))))))........))))))...(((((......))))).........))))))(......((..(((....)))(((...((((......(.(((((.......)))))......(((...((((...............(..)....)))).......))).)...((......)).))))......)))..((((....(((((((.((..(....(........((((((.].((.........))....((((((.............))))))....(((.(((..(((((....)))..)))))(((((........)))))........((..........(((((.......)))))..)..)....)))....)).))))....)..))).))))))).)))).)).....)).{..(((((.....]}.))))).......((..(((.((......((((.((((((..(((((.((((((((...............)))))))))))))..(((......[)))((((((..........]))))))(.((.....((...(((....[..)))...))....)).........(((....))).....)].....))))..))))))......((((..(.((((((.(.((.......)))..))))))...).)).).).....(((((.((((((..((.((((((......))))))...)).((((.......)))).....)))))..)...))).))....(((((((....))).))))..}.))..))).)).(((.(((......(....).....))).)))(((((...(((....))).)))))......(((................)))..............((((.......)))). Human mitochondrial ribosome in complex with mRNA and P-site tRNA; 16S mitochondrial rRNA 6zsb AA 924 4.5 RF00177 URS000044DFF6_9606 32812867 0003735 0005840 9606 auagguuugguccuagccuuucuauuagcucuuaguaagauuacacaugcaagcauccccguuccagugaguucacccucuaaaucgaucaaaaggaacaagcaucaagcacgcagcaaugcagcucaaaacgcuuagccuagccacacccccacgggaaacagcagugauuaaccuuuagcaauaaacgaaaguuuaacuaagcuauacuaaccccaggguuggucaauuucgugccagccaccgcggucacacgauuaacccaagucaauagaccggcguaaagaguguuuuagaucacaauaaagcuaaaacucaccugaguuguaaaaaacuccaguugacacaaaauagacuacgaaaguggcuuuaacauaucugaacacacaauagcuaagacccaaacugggauuagauaccccacuaugcuuagcccuaaaccucaacaguucaacaaaacugcucgccagaacacuacgagccacagcuuaaaacucaaaggaccuggcggugcuucauaucccucuagaggagccuguucuguaaucgauaaaccccgaucaaccucaccaccucuugcucagccuauauaccgccaucuucagcaaacccugaugaaggcuacaaaguaagcgcaaguacccacguaaagacguuaggucaagguguagcccaugagguggcaagaaaugggcuacauuuucuaccccagaaacgauagcccuuaugaauaagggucgaagguggauuuagcaguaaacuaagaguagagugcuuaguugaacagggcccugaagcgcguacacaccgcccgucacccuccucaaguauacuucaaaggacuuaacuaaaaccccuacgcauuuauauagaggagacaagucguaacaugguaaguguacuggaaagugcacuuggacgaac ..((((..<<<<<<.)))).<<<<<<.<<..<<<<<<<<..<.<<<.<<<..<......>......<<........<<<.<..<<..>>.>..>>>...<<<<....<<...<<<....>>>..>>......>>>>.<<...>>.>>.<<<....>>>.....>>>>>>>........<<<....<<<......>>>..>>>..>>.>>>>>>.....<<<<<<<<.....(((.....((.>>>)).......)))..>>>>>..>>.>>>>>>..<<<((.....<<<<..<<<<......<<<<<<......<<<.<<<.<<<......>>>..>>>.>>>.............<<....>>.>>>>>>.....>>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<.<<<<<..))..>>>>>.>.>>>.<<.......<<<<....>>>>.....>>..>>>>>><<<<<.<<<<<<<...<<<.<<<<<..<<<<<<<<<<.....<<........>>..........<<<<<<<.......<<.<<<..<<<<<<.<.....<<..<<<<<.....>>>.......>>..>>.....<<<....>>>.....>...>>>...>>>>>>>>....>>>>>>>..>>.>>>>>>>>.....<<<<.....>>>>.<....<<<<<<<....>>>>>>>....>.....>>>>>.....<<<<<<<.........>>>>>>>.....>>>...>>>>>>>>>>.>>....<..<<.<...<<<<<<..<<<<<..<...<<<..<<.....>>...>>>....>..>>>>>.>>>>>>....>.>>...>.....<<<<<<<<<....>>>>>>>>>........ 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Human mitochondrial ribosome in complex with mRNA and P-site tRNA; 12S mitochondrial rRNA 6zsc XA 1500 3.5 RF02541,RF02540 URS00021ED9A3_9606 32812867 0003735 0005840 9606 gcuaaaccuagccccaaacccacuccaccuuacuaccagacaaccuuagccaaaccauuuacccaaauaaaguauaggcgauagaaauugaaaccuggcgcaauagauauaguaccgcaagggaaagaugaaaaauuauaaccaagcauaauauagcaaggacuaaccccuauaccuucugcauaaugaauuaacuagaaauaacuuugcaaggagagccaaagcuaagacccccgaaaccagacgagcuaccuaagaacagcuaaaagagcacacccgucuauguagcaaaauagugggaagauuuauagguagaggcgacaaaccuaccgagccuggugauagcugguuguccaagauagaaucuuaguucaacuuuaaauuugcccacagaacccaaauccccuuguaaauuuaacuguuaguccaaagaggaacagcucuuuggacacuaggaaaaaaccuuguagagagaguaaaaaauuuaacacccauaguaggccuaaaagcagccaccaauuaagaaagcguucaagcucaacaccaaaaaucccaaacauauaacugaacuccucacacccaauuggaccaaucuaucacccuauagaagaacuaauguuaguauaaguaacaugaaaacauucuccuccgcauaagccugcgucagauaaccaacugacaauuaacagcccaauaucuacaaucaaccaacaagucauuauuacccucacugucaacccaacacaggcaugcucauaaggaaagguuaaaaaaaguaaaaggaacucggcaaaucuuaccccgccuguuuaccaaaaacaucaccucuagcaucaccaguauuagaggcaccgccugcccagugacacauguuuaacggccgcgguacccuaaccgugcaaagguagcauaaucacuuguuccuuaaauagggaccuguaugaauggcuccacgaggguucagcugucucuuacuuuuaaccagugaaauugaccugcccgugaagaggcgggcauaacacagcaagacgagaagacccuauggagcuuuaauuuauuaaugcaaacaguaaccaaaccugcauuaaaaauuucgguuggggcgaccucggagcagaacccaaccuccgagcaguacaugcuaagacuucaccagucaaagcgaaccucaauugauccaauaacuugaccaacggaacaaguuacccuagggauaacagcgcaauccuauucuagaguccauaucaacaauaggguuuacgaccucgauguuggaucaggacaucccgauggugcagccgcuauuaaagguucguuuguucaacgauuaaaguccuacgugaucugaguucagaccggaguaauccaggucgguuucuaucuacuuauuccucccuguacgaaaggacaagagaaauaaggccuacuucacaaagcgccuucccccguaaaugauaucaucucaacuuagaauacccacacccacccaagaacaggguu <<<.......<<<<.....................................<......>.........<.....<<.....>>....>........>>.>>.............<<....>>......................>>>...........<<<.......>>>...<.<........>.>.<<<<<<.........<<<.<<..<<....>>...>>.>>>...<<.<...<<<<.<.....<<<<<.<<<..<<<.....>>>...<<<..<<<<........>>>>.>>>....>>>.>>>>>...<<.......>>......>.>>>>......>.>>..<<<<<<....<<<<....>>>><<<.<<<<<<<<<<.....<<.......>>.....>>>>>>>>>>..>>>.<<<<<<<<<<......>>>>>>>>>>...<<<......>>>....<<<.<<<...<..............<....<<<.........>>>....>.......<<<......>>>...........................>...>>>>>>........>>>>>>...<<<<<......>>>>>.........>>>>>><......<<..<<<....>>><<<<..<<<<........<<<<<........>>>>>......<<<...<<<<.......................>>>>.......>>>.....<<......>>.>>>>.....>>>>..<<<<...<<<<<<<<.<<.........<......<<<<<<..<<<.........>>>...<<<<<<.............>>>>>>....<<<.<<<..<<<<<....>>>..>>>>><<<<<<......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>....>>.>>>>.....>..>>.>>>>>>>>>>>>.>>.....>.....<<<<<........>>>>>.......<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<...............>>>>>>>>>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<.....<<<..<<<<.....>>>>..>>>....>>.........<<<....>>>............>>>>..>>>>>>.......<<<..<.<<<<<<...<<.......>>...>>>>>>...>.>>.>.......<<<<<.<<<<<<..<<.<<<<<<......>>>>>>...>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>.<<<.<<<.................>>>.>>><<<<<...<<<....>>>.>>>>>......<<<................>>>..............<<<<.......>>>>. 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Human mitochondrial ribosome in complex with E-site tRNA; 16S mitochondrial rRNA 6zsc AA 924 3.5 RF00177 URS000044DFF6_9606 32812867 0003735 0005840 9606 auagguuugguccuagccuuucuauuagcucuuaguaagauuacacaugcaagcauccccguuccagugaguucacccucuaaaucgaucaaaaggaacaagcaucaagcacgcagcaaugcagcucaaaacgcuuagccuagccacacccccacgggaaacagcagugauuaaccuuuagcaauaaacgaaaguuuaacuaagcuauacuaaccccaggguuggucaauuucgugccagccaccgcggucacacgauuaacccaagucaauagaccggcguaaagaguguuuuagaucacaauaaagcuaaaacucaccugaguuguaaaaaacuccaguugacacaaaauagacuacgaaaguggcuuuaacauaucugaacacacaauagcuaagacccaaacugggauuagauaccccacuaugcuuagcccuaaaccucaacaguucaacaaaacugcucgccagaacacuacgagccacagcuuaaaacucaaaggaccuggcggugcuucauaucccucuagaggagccuguucuguaaucgauaaaccccgaucaaccucaccaccucuugcucagccuauauaccgccaucuucagcaaacccugaugaaggcuacaaaguaagcgcaaguacccacguaaagacguuaggucaagguguagcccaugagguggcaagaaaugggcuacauuuucuaccccagaaacgauagcccuuaugaauaagggucgaagguggauuuagcaguaaacuaagaguagagugcuuaguugaacagggcccugaagcgcguacacaccgcccgucacccuccucaaguauacuucaaaggacuuaacuaaaaccccuacgcauuuauauagaggagacaagucguaacaugguaaguguacuggaaagugcacuuggacgaac ..((((..<<<<<<.)))).<<<<<<.<...<<<<<<<<..<.<<<.<<<..<......>......<<........<<<.<..<<..>>.>..>>>...<<<<....<<...<<<....>>>..>>......>>>>.<<...>>.>>.<<<....>>>.....>>>>>>>........<<<....<<<......>>>..>>>..>>.>>>>>>.....<<<<<<<<.....(((.....((.>>>)).......)))..>>>>>...>.>>>>>>..<<<((.....<<<<..<<<<......<<<<<<......<<<.<<<.<<<......>>>..>>>.>>>............<<<....>>>>>>>>>.....>>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<.<<<<<..))..>>>>>.>.>>>.<<.......<<<<....>>>>.....>>..>>>>>><<<<<.<<<<<<<...<<<.<<<<<..<<<<<<<<<<.....<<........>>..........<<<<<<<.......<<.<<<..<<<<<<.<.....<<..<<<<<.....>>>.......>>..>>.....<<<....>>>.....>...>>>...>>>>>>>>....>>>>>>>..>>.>>>>>>>>.....<<<<.....>>>>.<....<<<<<<<....>>>>>>>....>.....>>>>>.....<<<<<<<.........>>>>>>>.....>>>...>>>>>>>>>>.>>....<..<<.<...<<<<<<..<<<<<..<...<<<..<<.....>>...>>>....>..>>>>>.>>>>>>....>.>>...>.....<<<<<<<<<....>>>>>>>>>........ [.[[[[..(((((..]]]]]((((((.((...(((((((....(((.(((..(......)......(((.......(((.(..((())).)..)))...((((....((..((((....))).)))......)))).((...))))).(((....))).....)))))).......(.(((...((((......))).))))).)).)))).).....((((([[[.....(((.....((.]]])).......)))..)))))..)).))))))..((([[...(.((((...(((......(((((((.....(((.(((.(((......)))..))).))).....).....(.((....))))))))).....)))....))))....((((((...((...((((.........))))...))))))))......{...(.(((((..]]..))))).))))).((.......((((....)))).....))...)))))((.((.(((((((...(((.(((((..((((((((((.....((........))..........(((((((.......((.(((...((((((.(....((..(((((.....))).......))..)).....(((....))).....).).)))...)).)))))....)))))))..)).)))))))).(...((((.....)))).(....(((((((....)))))))....)..)..))))).....(((((((.........))))))).....)))...)))))))))..))..(.(..((.(...((((((...((((..((..(((..((.....))...)))..).)..))))..))))))....).))...)..)..(((((((((....)))))))))}....... Human mitochondrial ribosome in complex with E-site tRNA; 12S mitochondrial rRNA 6zsd XA 1499 3.7 RF02541,RF02540 URS00021ED91E_9606 32812867 0003735 0005840 9606 gcuaaaccuagccccaaacccacuccaccuuacuaccagacaaccuuagccaaaccauuuacccaaauaaaguauaggcgauagaaauugaaaccuggcgcaauagauauaguaccgcaagggaaagaugaaaaauuauaaccaagcauaauauagcaaggacuaaccccuauaccuucugcauaaugaauuaacuagaaauaacuuugcaaggagagccaaagcuaagacccccgaaaccagacgagcuaccuaagaacagcuaaaagagcacacccgucuauguagcaaaauagugggaagauuuauagguagaggcgacaaaccuaccgagccuggugauagcugguuguccaagauagaaucuuaguucaacuuuaaauuugcccacagaacccaaauccccuuguaaauuuaacuguuaguccaaagaggaacagcucuuuggacacuaggaaaaaaccuuguagagagaguaaaaaauuuaacacccauaguaggccuaaaagcagccaccaauuaagaaagcguucaagcucaacaccaaaaaucccaaacauauaacugaacuccucacacccaauuggaccaaucuaucacccuauagaagaacuaauguuaguauaaguaacaugaaaacauucuccuccgcauaagccugcgucagauaacaacugacaauuaacagcccaauaucuacaaucaaccaacaagucauuauuacccucacugucaacccaacacaggcaugcucauaaggaaagguuaaaaaaaguaaaaggaacucggcaaaucuuaccccgccuguuuaccaaaaacaucaccucuagcaucaccaguauuagaggcaccgccugcccagugacacauguuuaacggccgcgguacccuaaccgugcaaagguagcauaaucacuuguuccuuaaauagggaccuguaugaauggcuccacgaggguucagcugucucuuacuuuuaaccagugaaauugaccugcccgugaagaggcgggcauaacacagcaagacgagaagacccuauggagcuuuaauuuauuaaugcaaacaguaaccaaaccugcauuaaaaauuucgguuggggcgaccucggagcagaacccaaccuccgagcaguacaugcuaagacuucaccagucaaagcgaaccucaauugauccaauaacuugaccaacggaacaaguuacccuagggauaacagcgcaauccuauucuagaguccauaucaacaauaggguuuacgaccucgauguuggaucaggacaucccgauggugcagccgcuauuaaagguucguuuguucaacgauuaaaguccuacgugaucugaguucagaccggaguaauccaggucgguuucuaucuacuuauuccucccuguacgaaaggacaagagaaauaaggccuacuucacaaagcgccuucccccguaaaugauaucaucucaacuuagaauacccacacccacccaagaacaggguu <<<.......<<<<.....................................<......>.........<.....<<.....>>....>........>>.>>.............<<....>>......................>>>...........<<<.......>>>...<.<........>.>.<<<<<<.........<<<.<<..<<....>>...>>.>>>...<<.<...<<<<.<.....<<<<<.<<<..<<<.....>>>...<<<..<<<<........>>>>.>>>....>>>.>>>>>...<<.......>>......>.>>>>......>.>>..<<<<<<....<<<<....>>>><<<.<<<<<<<<<<.....<<.......>>.....>>>>>>>>>>..>>>.<<<<<<<<<<......>>>>>>>>>>.<.<<<......>>>.>..<<<.<<<...<..............<....<<<.........>>>....>.......<<<......>>>...........................>...>>>>>>........>>>>>>...<<<<<......>>>>>.........>>>>>><......<<..<<<....>>><<<<..<<<<........<<<<<.......>>>>>......<<<...<<<<.......................>>>>.......>>>.....<<......>>.>>>>.....>>>>..<<<<...<<<<<<<<.<<.........<......<<<<<<..<<<.........>>>...<<<<<<.............>>>>>>....<<<.<<<..<<<<<....>>>..>>>>><<<<<<......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>....>>.>>>>.....>..>>.>>>>>>>>>>>>.>>.....>.....<<<<<........>>>>>.......<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<...............>>>>>>>>>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<.....<<<..<<<<.....>>>>..>>>....>>.........<<<....>>>............>>>>..>>>>>>.......<<<..<.<<<<<<...<<.......>>...>>>>>>...>.>>.>.......<<<<<.<<<<<<..<<.<<<<<<......>>>>>>...>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>.<<<.<<<......<....>.....>>>.>>><<<<<...<<<....>>>.>>>>>......<<<................>>>..............<<<<.......>>>>. 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Human mitochondrial ribosome in complex with mRNA, P-site tRNA and E-site tRNA; 16S mitochondrial rRNA 6zsd AA 924 3.7 RF00177 URS000044DFF6_9606 32812867 0003735 0005840 9606 auagguuugguccuagccuuucuauuagcucuuaguaagauuacacaugcaagcauccccguuccagugaguucacccucuaaaucgaucaaaaggaacaagcaucaagcacgcagcaaugcagcucaaaacgcuuagccuagccacacccccacgggaaacagcagugauuaaccuuuagcaauaaacgaaaguuuaacuaagcuauacuaaccccaggguuggucaauuucgugccagccaccgcggucacacgauuaacccaagucaauagaccggcguaaagaguguuuuagaucacaauaaagcuaaaacucaccugaguuguaaaaaacuccaguugacacaaaauagacuacgaaaguggcuuuaacauaucugaacacacaauagcuaagacccaaacugggauuagauaccccacuaugcuuagcccuaaaccucaacaguucaacaaaacugcucgccagaacacuacgagccacagcuuaaaacucaaaggaccuggcggugcuucauaucccucuagaggagccuguucuguaaucgauaaaccccgaucaaccucaccaccucuugcucagccuauauaccgccaucuucagcaaacccugaugaaggcuacaaaguaagcgcaaguacccacguaaagacguuaggucaagguguagcccaugagguggcaagaaaugggcuacauuuucuaccccagaaacgauagcccuuaugaauaagggucgaagguggauuuagcaguaaacuaagaguagagugcuuaguugaacagggcccugaagcgcguacacaccgcccgucacccuccucaaguauacuucaaaggacuuaacuaaaaccccuacgcauuuauauagaggagacaagucguaacaugguaaguguacuggaaagugcacuuggacgaac ..((((..<<<<<<.)))).<<<<<<.<<...<<<<<<<..<.<<<.<<<..<......>......<<........<<<.<..<<..>>.>..>>>...<<<<....<<...<<<....>>>..>>......>>>>.<<...>>.>>.<<<....>>>.....>>>>>>>........<<<....<<<......>>>..>>>..>>.>>>>>......<<<<<<<<.....(((.....((.>>>)).......)))..>>>>>..>>.>>>>>>..<<<((.....<<<<..<<<<......<<<<<<......<<<.<<<.<<<......>>>..>>>.>>>............<<<....>>>>>>>>>.....>>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<.<<<<<..))..>>>>>.>.>>>.<<.......<<<<....>>>>.....>>..>>>>>><<<<<.<<<<<<<...<<<.<<<<<..<<<<<<<<<<.....<<........>>..........<<<<<<<.......<<.<<<..<<<<<<.<.....<<..<<<<<.....>>>.......>>..>>.....<<<....>>>.....>...>>>...>>>>>>>>....>>>>>>>..>>.>>>>>>>>.....<<<<.....>>>>.<....<<<<<<<....>>>>>>>....>.....>>>>>.....<<<<<<<.........>>>>>>>.....>>>...>>>>>>>>>>.>>....<..<<.<...<<<<<<..<<<<<..<...<<<..<<.....>>...>>>....>..>>>>>.>>>>>>....>.>>...>.....<<<<<<<<<....>>>>>>>>>........ 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Human mitochondrial ribosome in complex with mRNA, P-site tRNA and E-site tRNA; 12S mitochondrial rRNA 6zse XA 1499 5.0 RF02541,RF02540 URS00021ED931_9606 32812867 0003735 0005840 9606 gcuaaaccuagccccaaacccacuccaccuuacuaccagacaaccuuagccaaaccauuuacccaaauaaaguauaggcgauagaaauugaaaccuggcgcaauagauauaguaccgcaagggaaagaugaaaaauuauaaccaagcauaauauagcaaggacuaaccccuauaccuucugcauaaugaauuaacuagaaauaacuuugcaaggagagccaaagcuaagacccccgaaaccagacgagcuaccuaagaacagcuaaaagagcacacccgucuauguagcaaaauagugggaagauuuauagguagaggcgacaaaccuaccgagccuggugauagcugguuguccaagauagaaucuuaguucaacuuuaaauuugcccacagaacccaaauccccuuguaaauuuaacuguuaguccaaagaggaacagcucuuuggacacuaggaaaaaaccuuguagagagaguaaaaaauuuaacacccauaguaggccuaaaagcagccaccaauuaagaaagcguucaagcucaacaccaaaaaucccaaacauauaacugaacuccucacacccaauuggaccaaucuaucacccuauagaagaacuaauguuaguauaaguaacaugaaaacauucuccuccgcauaagccugcgucagauaacaacugacaauuaacagcccaauaucuacaaucaaccaacaagucauuauuacccucacugucaacccaacacaggcaugcucauaaggaaagguuaaaaaaaguaaaaggaacucggcaaaucuuaccccgccuguuuaccaaaaacaucaccucuagcaucaccaguauuagaggcaccgccugcccagugacacauguuuaacggccgcgguacccuaaccgugcaaagguagcauaaucacuuguuccuuaaauagggaccuguaugaauggcuccacgaggguucagcugucucuuacuuuuaaccagugaaauugaccugcccgugaagaggcgggcauaacacagcaagacgagaagacccuauggagcuuuaauuuauuaaugcaaacaguaaccaaaccugcauuaaaaauuucgguuggggcgaccucggagcagaacccaaccuccgagcaguacaugcuaagacuucaccagucaaagcgaaccucaauugauccaauaacuugaccaacggaacaaguuacccuagggauaacagcgcaauccuauucuagaguccauaucaacaauaggguuuacgaccucgauguuggaucaggacaucccgauggugcagccgcuauuaaagguucguuuguucaacgauuaaaguccuacgugaucugaguucagaccggaguaauccaggucgguuucuaucuacuuauuccucccuguacgaaaggacaagagaaauaaggccuacuucacaaagcgccuucccccguaaaugauaucaucucaacuuagaauacccacacccacccaagaacaggguu <<<.......<<<<.....................................<......>.........<.....<<.....>>....>........>>.>>.............<<....>>......................>>>...........<<<.......>>>...<.<........>.>.<<<<<<.........<<<.<<..<<....>>...>>.>>>...<<.<..<<<<<.<.....<<<<<.<<<..<<<.....>>>...<<<..<<<<........>>>>.>>>....>>>.>>>>>...<<.......>>......>.>>>>...>..>.>>..<<<<<<....<<<<....>>>><<<.<<<<<<<<<<.....<<.......>>.....>>>>>>>>>>..>>>.<<<<<<<<<<......>>>>>>>>>>.<.<<<......>>>.>..<<<.<<<...<..............<....<<<.........>>>....>.......<<<......>>>...........................>...>>>>>>........>>>>>>...<<<<<......>>>>>.........>>>>>><......<<..<<<....>>><<<<..<<<<........<<<<<.......>>>>>......<<<...<<<<.......................>>>>.......>>>.....<<......>>.>>>>.....>>>>..<<<<...<<<<<<<<.<<.........<......<<<<<<..<<<.........>>>...<<<<<<.............>>>>>>....<<<.<<<..<<<<<....>>>..>>>>><<<<<<......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>....>>.>>>>.....>..>>.>>>>>>>>>>>>.>>.....>.....<<<<<........>>>>>.......<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<...............>>>>>>>>>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<.....<<<..<<<<.....>>>>..>>>....>>.........<<<....>>>............>>>>..>>>>>>.......<<<..<.<<<<<<...<<.......>>...>>>>>>...>.>>.>.......<<<<<.<<<<<<..<<.<<<<<<......>>>>>>...>>.<<<<.......>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>.<<<.<<<.................>>>.>>><<<<<...<<<....>>>.>>>>>......<<<................>>>..............<<<<.......>>>>. 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Human mitochondrial ribosome in complex with mRNA, A/P-tRNA and P/E-tRNA; 16S mitochondrial rRNA 6zse AA 924 5.0 RF00177 URS00021ED97E_9606 32812867 0003735 0005840 9606 auagguuugguccuagccuuucuauuagcucuuaguaagauuacacaugcaagcauccccguuccagugaguucacccucuaaaucgaucaaaaggaacaagcaucaagcacgcagcaaugcagcucaaaacgcuuagccuagccacacccccacgggaaacagcagugauuaaccuuuagcaauaaacgaaaguuuaacuaagcuauacuaaccccaggguuggucaauuucgugccagccaccgcggucacacgauuaacccaagucaauagaccggcguaaagaguguuuuagaucacaauaaagcuaaaacucaccugaguuguaaaaaacuccaguugacacaaaauagacuacgaaaguggcuuuaacauaucugaacacacaauagcuaagacccaaacugggauuagauaccccacuaugcuuagcccuaaaccucaacaguucaacaaaacugcucgccagaacacuacgagccacagcuuaaaacucaaaggaccuggcggugcuucauaucccucuagaggagccuguucuguaaucgauaaaccccgaucaaccucaccaccucuugcucagccuauauaccgccaucuucagcaaacccugaugaaggcuacaaaguaagcgcaaguacccacguaaagacguuaggucaagguguagcccaugagguggcaagaaaugggcuacauuuucuaccccagaaacgauagcccuuaugaauaagggucgaagguggauuuagcaguaaacuaagaguagagugcuuaguugaacagggcccugaagcgcguacacaccgcccgucacccuccucaaguauacuucaaaggacuuaacuaaaaccccuacgcauuuauauagaggagacaagucguaacaugguaaguguacuggaaagugcacuuggacgaac ..((((..<<<<<<.)))).<<<<<<.<<..<<<<<<<<..<.<<<.<<<..<......>......<<........<<<.<..<<..>>.>..>>>...<<<<....<<...<<<....>>>..>>......>>>>.<<...>>.>>.<<<....>>>.....>>>>>>>........<<<....<<<......>>>..>>>..>>.>>>>>>.....<<<<<<<<.....(((.....((.>>>)).......)))..>>>>>..>>.>>>>>>..<<<((.....<<<<..<<<<......<<<<<<......<<<.<<<.<<<......>>>..>>>.>>>.............<<....>>.>>>>>>.....>>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<.<<<<<..))..>>>>>.>.>>>.<<.......<<<<....>>>>.....>>..>>>>>><<<<<.<<<<<<<...<<<.<<<<...<<<<<<<<<<.....<<........>>..........<<<<<<<.......<<.<<<..<<<<<<.<.....<<..<<<<<.....>>>.......>>..>>.....<<<....>>>.....>...>>>...>>>>>>>>....>>>>>>>..>>.>>>>>>>>.....<<<<.....>>>>.<....<<<<<<<....>>>>>>>....>......>>>>.....<<<<<<<.........>>>>>>>.....>>>...>>>>>>>>>>.>>....<..<<.<...<<<<<<..<<<<<..<...<<<..<<.....>>...>>>....>..>>>>>.>>>>>>....>.>>...>.....<<<<<<<<<....>>>>>>>>>........ 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Human mitochondrial ribosome in complex with mRNA, A/P-tRNA and P/E-tRNA; 12S mitochondrial rRNA 6zsg XA 1499 4.0 RF02541,RF02540 URS00021ED931_9606 32812867 0003735 0005840 9606 gcuaaaccuagccccaaacccacuccaccuuacuaccagacaaccuuagccaaaccauuuacccaaauaaaguauaggcgauagaaauugaaaccuggcgcaauagauauaguaccgcaagggaaagaugaaaaauuauaaccaagcauaauauagcaaggacuaaccccuauaccuucugcauaaugaauuaacuagaaauaacuuugcaaggagagccaaagcuaagacccccgaaaccagacgagcuaccuaagaacagcuaaaagagcacacccgucuauguagcaaaauagugggaagauuuauagguagaggcgacaaaccuaccgagccuggugauagcugguuguccaagauagaaucuuaguucaacuuuaaauuugcccacagaacccaaauccccuuguaaauuuaacuguuaguccaaagaggaacagcucuuuggacacuaggaaaaaaccuuguagagagaguaaaaaauuuaacacccauaguaggccuaaaagcagccaccaauuaagaaagcguucaagcucaacaccaaaaaucccaaacauauaacugaacuccucacacccaauuggaccaaucuaucacccuauagaagaacuaauguuaguauaaguaacaugaaaacauucuccuccgcauaagccugcgucagauaacaacugacaauuaacagcccaauaucuacaaucaaccaacaagucauuauuacccucacugucaacccaacacaggcaugcucauaaggaaagguuaaaaaaaguaaaaggaacucggcaaaucuuaccccgccuguuuaccaaaaacaucaccucuagcaucaccaguauuagaggcaccgccugcccagugacacauguuuaacggccgcgguacccuaaccgugcaaagguagcauaaucacuuguuccuuaaauagggaccuguaugaauggcuccacgaggguucagcugucucuuacuuuuaaccagugaaauugaccugcccgugaagaggcgggcauaacacagcaagacgagaagacccuauggagcuuuaauuuauuaaugcaaacaguaaccaaaccugcauuaaaaauuucgguuggggcgaccucggagcagaacccaaccuccgagcaguacaugcuaagacuucaccagucaaagcgaaccucaauugauccaauaacuugaccaacggaacaaguuacccuagggauaacagcgcaauccuauucuagaguccauaucaacaauaggguuuacgaccucgauguuggaucaggacaucccgauggugcagccgcuauuaaagguucguuuguucaacgauuaaaguccuacgugaucugaguucagaccggaguaauccaggucgguuucuaucuacuuauuccucccuguacgaaaggacaagagaaauaaggccuacuucacaaagcgccuucccccguaaaugauaucaucucaacuuagaauacccacacccacccaagaacaggguu <<<.......<<<<.....................................<......>.........<.....<<.....>>....>........>>.>>.............<<....>>......................>>>...........<<<.......>>>...<.<........>.>.<<<<<<.........<<<.<<..<<....>>...>>.>>>...<<.<..<<<<<.<.....<<<<<.<<<..<<<.....>>>...<<<..<<<<........>>>>.>>>....>>>.>>>>>...<<.......>>......>.>>>>...>..>.>>..<<<<<<....<<<<....>>>><<<.<<<<<<<<<<.....<<.......>>.....>>>>>>>>>>..>>>.<<<<<<<<<<......>>>>>>>>>>...<<<......>>>....<<<.<<<...<..............<....<<<.........>>>....>.......<<<......>>>...........................>...>>>>>>........>>>>>>...<<<<<......>>>>>.........>>>>>><......<<..<<<....>>><<<<..<<<<........<<<<<.......>>>>>......<<<...<<<<.......................>>>>.......>>>.....<<......>>.>>>>.....>>>>..<<<<...<<<<<<<<.<<.........<......<<<<<<..<<<.........>>>...<<<<<<.............>>>>>>....<<<.<<<..<<<<<....>>>..>>>>><<<<<<......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>....>>.>>>>.....>..>>.>>>>>>>>>>>>.>>.....>.....<<<<<........>>>>>.......<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<...............>>>>>>>>>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<.....<<<..<<<<.....>>>>..>>>....>>.........<<<....>>>............>>>>..>>>>>>.......<<<..<.<<<<<<...<<.......>>...>>>>>>...>.>>.>.......<<<<<.<<<<<<..<<.<<<<<<......>>>>>>...>>.<<<<.......>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>.<<<.<<<......<....>.....>>>.>>><<<<<...<<<....>>>.>>>>>......<<<................>>>..............<<<<.......>>>>. ((.....(..((((.....................................(...[..).........(.....((.]...))....)........)).)).............((....))....)..................)).........(.(((.......))).[.(.(........).).((((((.........(((.((..((....))...)).)))...((.(...((((.(.....(((((.((((.(((....[)))...(((..((((.......{)))).)))..).))).))))).(.((.......))...)..).))))......).))..((((((....((((....))))..(.((((((((((.....((.......)).....))))))))))..)...((((((((((......))))))))))...(((......)))....(((.(((...(..............(....(((.........)))....)....(..(((......))))..........................)...))))))........))))))...(((((......))))).........))))))(......((..(((....)))((((..((((......(.(((((.......)))))......(((...((((...............(..)....)))).......))).)...((......)).)))).....))))..((((....(((((((.((..(....(........((((((.].((.........))....((((((.............))))))....(((.(((..(((((....)))..)))))(((((........)))))........((..........(((((.......)))))..)..)....)))....)).))))....)..))).))))))).)))).)).....)).{..(((((.....]}.))))).......((..(((.((......((((.((((((..(((((.((((((((...............)))))))))))))..(((......[)))((((((..........]))))))(.((.....((...(((....[..)))...))....)).........(((....))).....)].....))))..))))))......((((..(.((((((.(.((.......)))..))))))...).)).).).....(((((.((((((..((.((((((......))))))...)).(((((.....))))).....)))))..)...))).))....(((((((....))).))))..}.))..))).)).(((.(((......(....).....))).)))(((((...(((....))).)))))......(((................)))..............((((.......)))). Human mitochondrial ribosome in complex with mRNA, A-site tRNA, P-site tRNA and E-site tRNA; 16S mitochondrial rRNA 6zsg AA 924 4.0 RF00177 URS000044DFF6_9606 32812867 0003735 0005840 9606 auagguuugguccuagccuuucuauuagcucuuaguaagauuacacaugcaagcauccccguuccagugaguucacccucuaaaucgaucaaaaggaacaagcaucaagcacgcagcaaugcagcucaaaacgcuuagccuagccacacccccacgggaaacagcagugauuaaccuuuagcaauaaacgaaaguuuaacuaagcuauacuaaccccaggguuggucaauuucgugccagccaccgcggucacacgauuaacccaagucaauagaccggcguaaagaguguuuuagaucacaauaaagcuaaaacucaccugaguuguaaaaaacuccaguugacacaaaauagacuacgaaaguggcuuuaacauaucugaacacacaauagcuaagacccaaacugggauuagauaccccacuaugcuuagcccuaaaccucaacaguucaacaaaacugcucgccagaacacuacgagccacagcuuaaaacucaaaggaccuggcggugcuucauaucccucuagaggagccuguucuguaaucgauaaaccccgaucaaccucaccaccucuugcucagccuauauaccgccaucuucagcaaacccugaugaaggcuacaaaguaagcgcaaguacccacguaaagacguuaggucaagguguagcccaugagguggcaagaaaugggcuacauuuucuaccccagaaacgauagcccuuaugaauaagggucgaagguggauuuagcaguaaacuaagaguagagugcuuaguugaacagggcccugaagcgcguacacaccgcccgucacccuccucaaguauacuucaaaggacuuaacuaaaaccccuacgcauuuauauagaggagacaagucguaacaugguaaguguacuggaaagugcacuuggacgaac ..((((..<<<<<<.)))).<<<<<<.<<..<<<<<<<<..<.<<<.<<<..<......>......<<........<<<.<..<<..>>.>..>>>...<<<<....<<...<<<....>>>..>>......>>>>.<<...>>.>>.<<<....>>>.....>>>>>>>........<<<....<<<......>>>..>>>..>>.>>>>>>.....<<<<<<<<.....(((.....((.>>>)).......)))..>>>>>..>>.>>>>>>..<<<((.....<<<<..<<<<......<<<<<<......<<<.<<<.<<<......>>>..>>>.>>>............<<<....>>>>>>>>>.....>>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<.<<<<<..))..>>>>>.>.>>>.<<.......<<<<....>>>>.....>>..>>>>>><<<<<.<<<<<<<...<<<.<<<<<..<<<<<<<<<<.....<<........>>..........<<<<<<<.......<<.<<<..<<<<<<.......<<..<<<<<.....>>>.......>>..>>.....<<<....>>>.........>>>...>>>>>>>>....>>>>>>>..>>.>>>>>>>>.....<<<<.....>>>>.<....<<<<<<<....>>>>>>>....>.....>>>>>.....<<<<<<<.........>>>>>>>.....>>>...>>>>>>>>>>.>>....<..<<.<...<<<<<<..<<<<<..<...<<<..<<.....>>...>>>....>..>>>>>.>>>>>>....>.>>...>.....<<<<<<<<<....>>>>>>>>>........ [.[[[[..(((((..]]]]]((((((.((...(((((((....(((.(((..(......)......(((.......(((.(..((())).)..)))...((((....((..((((....))).)))......)))).((...))))).(((....))).....)))))).......(.(((...(((((....)))).))))).)).)))).).....((((([[[.....(((.....((.]]])).......)))..)))))..)).))))))..((([[...(.((((...(((......(((((((.....(((.(((.((........))..))).))).....).....(.((....))))))))).....)))....))))....((((((...((...((((.........))))...))))))))......{...(.(((((..]]..))))).))))).((.......((((....)))).....))...)))))(((((.(((((((...(((.(((((..((((((((((.....((........))..........(((((((.......((.(((...((((((.(....((..(((((.....))).......))..))......((....))......).).)))...)).)))))....)))))))..)).)))))))).(...((((.....)))).(....(((((((....)))))))....)..)..))))).....(((((((.........))))))).....)))...)))))))))).))..(.(..((.(...((((((...((((..((..(((..((.....))...)))..).)..))))..))))))....).))...)..)..(((((((((....)))))))))}....... Human mitochondrial ribosome in complex with mRNA, A-site tRNA, P-site tRNA and E-site tRNA; 12S mitochondrial rRNA 6ztj AA 1533 3.4 RF00177,RF01959,RF01960 URS000036C8BF_562 32820062 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagcagcuugcugcuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauc ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<<....>>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>..<<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>>.<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<....<.<<<<<<.....>>>>>>.>..>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<..<.<<<<<<<........>>>>>>>>...>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((.(....).))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((.(....).))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))...((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... E. coli 70S-RNAP expressome complex in NusG-coupled state (38 nt intervening mRNA); 16S ribosomal RNA 6ztj AV 40 3.4 32820062 32630 ucauguucacauacacauauauagacacaaacggcgcgcg ........................................ ........................................ E. coli 70S-RNAP expressome complex in NusG-coupled state (38 nt intervening mRNA); mRNA 6ztj AW 77 3.4 RF00005 URS00001BBAFC_562 32820062 0030533 0006412 562 cgcggggnggagcagccuggnagcucgucgggnucauaacccgaagaucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... E. coli 70S-RNAP expressome complex in NusG-coupled state (38 nt intervening mRNA); tRNA(fmet) P-site 6ztj AX 76 3.4 RF00005 URS00005AA258_562 32820062 0030533 0006412 562 gcccgganagcucagncggnagagcaggggauugaanauccccgunnccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((.........)))).....(((((..]....)))))))))))).... E. coli 70S-RNAP expressome complex in NusG-coupled state (38 nt intervening mRNA); Phe-NH-tRNA(Phe) A-site 6ztj BA 2900 3.4 RF02540,RF02541 URS00021ED998_562 32820062 0003735 0005840 562 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<<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<.>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<.........>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>.>......>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<<<<...<.<......<<<<<<<<....>>>>>>>>...>.>.............>>>>...>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>.(<<...<<<<<<<...<<<<<<.......>>>>>>.....<<)..(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....(((((((..(((]]]..].)))......)))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((.(((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))))))).)))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((.))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((((.(.....).))).))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{..((((.(((..(((.........)))..))).....(..(((......)))).))))....)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((....((((..)])))....)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........((.((..((....))...)).))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((.(((.((.(.(.........((((...(((.......((..(((....)))..))....))).............))))).).)).))).)))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). E. coli 70S-RNAP expressome complex in NusG-coupled state (38 nt intervening mRNA); 23S ribosomal RNA 6ztj BB 120 3.4 RF00001 URS0000049E57_562 32820062 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). E. coli 70S-RNAP expressome complex in NusG-coupled state (38 nt intervening mRNA); 5S ribosomal RNA 6ztl AA 1533 3.5 RF00177,RF01959,RF01960 URS000036C8BF_562 32820062 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagcagcuugcugcuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauc ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<<<..>>>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<.......<<<....>>>......>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((.((((.(....).))))..)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((.(....).))))......)).).....(((....))).....((.((...(....).)).))..)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(...((((.((((.......)))).))).)...)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...(((((((.(...(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((.(((....))).)))...((....))..))))).))).((.(((...((.(((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).))....)).)))))....)))))))...)).)))))))).(...((((((......(((..((...(((....)))...))....)))......))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((...((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))....))...)..)..(((((((((....)))))))))}.... E. coli 70S-RNAP expressome complex in collided state bound to NusG; 16S ribosomal RNA 6ztl AV 34 3.5 32820062 32630 ucauguucacauacacauacacaaacggcgcgcg .................................. .................................. E. coli 70S-RNAP expressome complex in collided state bound to NusG; mRNA 6ztl AW 77 3.5 RF00005 URS00001BBAFC_562 32820062 0030533 0006412 562 cgcggggnggagcagccuggnagcucgucgggnucauaacccgaagaucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... E. coli 70S-RNAP expressome complex in collided state bound to NusG; tRNA(fmet) P-site 6ztl AX 76 3.5 RF00005 URS00005AA258_562 32820062 0030533 0006412 562 gcccgganagcucagncggnagagcaggggauugaanauccccgunnccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((.........)))).....(((((..]....)))))))))))).... E. coli 70S-RNAP expressome complex in collided state bound to NusG; Phe-NH-tRNA(Phe) A-site 6ztl BA 2899 3.5 RF02540,RF02541 URS00021ED998_562 32820062 0003735 0005840 562 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<<<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<......>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<<..>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<<.....>>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<......>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.......<<<<<<.<<....>>..>>>>>>.......>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<.<<.<<.............<<<<.....<......<<<<<<<<....>>>>>>>>...>...............>>>>....>>.>>.>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((..((((.(((.(((...(((((......)))))[[(...).(((.....]])))...)))...))).))))..)))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((())))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..(((.......))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((.((.(.....).))..))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((.((..(((.....{..((((.(((..((((.......))))..))).....(..(((......)))).))))....)))..)).)).))...........]]].)...))))))))))...)))))))((((.((((....)))).))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))...((((........)))).]](((.(((((((((...((((....((((..(((..(((((.((((((...{{..).))))).((..(((....((((((((((((.((.....))))))))))..))))..[.)))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))).))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(.(((.........))).)........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((((..(.(.((.(.(.........((((...(((.......((..(((....)))..))....))).............))))).).)).).)..))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....((((((..((..]]]]..)).)))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). E. coli 70S-RNAP expressome complex in collided state bound to NusG; 23S ribosomal RNA 6ztl BB 120 3.5 RF00001 URS0000049E57_562 32820062 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((.(((((...))))).)).......))...)))))))))). E. coli 70S-RNAP expressome complex in collided state bound to NusG; 5S ribosomal RNA 6ztm AA 1533 3.3 RF00177,RF01959,RF01960 URS000036C8BF_562 32820062 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagcagcuugcugcuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauc ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<<....>>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<..<.<<<<<<<........>>>>>>>>...>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((.((((((....))))))..)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(..(.((((((((.......)))))))).)...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))...((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... E. coli 70S-RNAP expressome complex in collided state without NusG; 16S ribosomal RNA 6ztm AV 30 3.3 32820062 32630 ucauguucacauacacacaaacggcgcgcg .............................. .............................. E. coli 70S-RNAP expressome complex in collided state without NusG; mRNA 6ztm AW 77 3.3 RF00005 URS00001BBAFC_562 32820062 0030533 0006412 562 cgcggggnggagcagccuggnagcucgucgggnucauaacccgaagaucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... E. coli 70S-RNAP expressome complex in collided state without NusG; tRNA(fmet) P-site 6ztm AX 76 3.3 RF00005 URS00005AA258_562 32820062 0030533 0006412 562 gcccgganagcucagncggnagagcaggggauugaanauccccgunnccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((.........)))).....(((((..]....)))))))))))).... E. coli 70S-RNAP expressome complex in collided state without NusG; Phe-NH-tRNA(Phe) A-site 6ztm BA 2901 3.3 RF02540,RF02541 URS00021ED998_562 32820062 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacagaucugugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugugaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccgugauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacuccuugagaguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<..>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<.......>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<.........>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>.>......>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<..<<<............<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>...>>>..>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>.(<<...<<<<<<<...<<<<<<.......>>>>>>.....<<)..(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......((((.((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))).))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((()))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((.((.(.....).))..))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(...((((....))))....))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((....((((..)])))....)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((((..(.(.((.(.((...)....(..((..(((.......((.((((....)))).))....)))............))..)).).)).).)..))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). E. coli 70S-RNAP expressome complex in collided state without NusG; 23S ribosomal RNA 6ztm BB 120 3.3 RF00001 URS0000049E57_562 32820062 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). E. coli 70S-RNAP expressome complex in collided state without NusG; 5S ribosomal RNA 6ztn AA 1533 3.9 RF00177,RF01959,RF01960 URS000036C8BF_562 32820062 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagcagcuugcugcuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauc ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<......>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<.......<<<....>>>......>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<....>>>>>>....<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((((....))))))).)))))..)))))......(((......(((((((..((...(.(((((.(.((.....((((.(....).))))......)).).....(((....)))....(((.((..((....)))).))).))))).)..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(..(.(((.((((.......)))).))).)...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((.(((....))).)))...((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...((((((......(((..((...(((....)))...))....)))......))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... E. coli 70S-RNAP expressome complex in NusG-coupled state (42 nt intervening mRNA); 16S ribosomal RNA 6ztn AV 31 3.9 32820062 32630 uucauguucacauacacacaaacggcgcgcg ............................... ............................... E. coli 70S-RNAP expressome complex in NusG-coupled state (42 nt intervening mRNA); mRNA 6ztn AW 77 3.9 RF00005 URS00001BBAFC_562 32820062 0030533 0006412 562 cgcggggnggagcagccuggnagcucgucgggnucauaacccgaagaucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... E. coli 70S-RNAP expressome complex in NusG-coupled state (42 nt intervening mRNA); tRNA(fmet) P-site 6ztn AX 76 3.9 RF00005 URS00005AA258_562 32820062 0030533 0006412 562 gcccgganagcucagncggnagagcaggggauugaanauccccgunnccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((.........)))).....(((((..]....)))))))))))).... E. coli 70S-RNAP expressome complex in NusG-coupled state (42 nt intervening mRNA); Phe-NH-tRNA(Phe) A-site 6ztn AZ 76 3.9 RF00005 URS00005AA258_562 32820062 0030533 0006412 562 gcccgganagcucagncggnagagcaggggauugaanauccccgunnccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((.........)))).....((.((..]....)).))))))))).... E. coli 70S-RNAP expressome complex in NusG-coupled state (42 nt intervening mRNA); Phe-NH-tRNA(Phe) A-site 6ztn BA 2899 3.9 RF02540,RF02541 URS00021ED998_562 32820062 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacagcugugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugugaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccgugauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacuccuugagaguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<..>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<.......>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<.........>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<<.<<....>>..>>>>>>.>.....>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<.<<.<<<............<<<<....<.......<<<<<<<<....>>>>>>>>....>..............>>>>...>>>.>>.>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((..((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))))))..)))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((())))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((.((.(.....).))..))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..((((.......))))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...(((.((((((((.((.....))))))))))...)))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.((..(((((.((((((....(.((.(.(.........(((((...((......(((..(((....)))..)))...)).............)))))).).)).)....))))))...(((.((((((.....)))))))))....)))))..))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). E. coli 70S-RNAP expressome complex in NusG-coupled state (42 nt intervening mRNA); 23S ribosomal RNA 6ztn BB 120 3.9 RF00001 URS0000049E57_562 32820062 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). E. coli 70S-RNAP expressome complex in NusG-coupled state (42 nt intervening mRNA); 5S ribosomal RNA 6zto AA 1533 3.0 RF00177,RF01959,RF01960 URS000036C8BF_562 32820062 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagcagcuugcugcuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauc ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<<....>>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((((....))))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((.(....).))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))...((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... E. coli 70S-RNAP expressome complex in uncoupled state 1; 16S ribosomal RNA 6zto AV 27 3.0 32820062 32630 ucauguucacauaccaaacggcgcgcg ........................... ........................... E. coli 70S-RNAP expressome complex in uncoupled state 1; mRNA 6zto AW 77 3.0 RF00005 URS00001BBAFC_562 32820062 0030533 0006412 562 cgcggggnggagcagccuggnagcucgucgggnucauaacccgaagaucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... E. coli 70S-RNAP expressome complex in uncoupled state 1; tRNA(fmet) P-site 6zto AX 76 3.0 RF00005 URS00005AA258_562 32820062 0030533 0006412 562 gcccgganagcucagncggnagagcaggggauugaanauccccgunnccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((.........)))).....(((((..]....)))))))))))).... E. coli 70S-RNAP expressome complex in uncoupled state 1; Phe-NH-tRNA(Phe) A-site 6zto BA 2900 3.0 RF02540,RF02541 URS00021ED998_562 32820062 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacagacugugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugugaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccgugauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacuccuugagaguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<.>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<<.....>>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<.........>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<..<<....>>...>>>>>..>....>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<.............<<<<...<.<......<<<<<<<<....>>>>>>>>...>.>.............>>>>....>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>.(<<...<<<<<<<...<<<<<<.......>>>>>>.....<<)..(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......((((.((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))).))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((.))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((.((((.....))))..))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((.(.((.(.(.........((((...(((.......((.((((....)))).))....))).............))))).).)).).)))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). E. coli 70S-RNAP expressome complex in uncoupled state 1; 23S ribosomal RNA 6zto BB 120 3.0 RF00001 URS0000049E57_562 32820062 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). E. coli 70S-RNAP expressome complex in uncoupled state 1; 5S ribosomal RNA 6ztp AA 1533 3.0 RF00177,RF01959,RF01960 URS000036C8BF_562 32820062 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagcagcuugcugcuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauc ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<<....>>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((((....))))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((.(....).))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))...((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... E. coli 70S-RNAP expressome complex in uncoupled state 6; 16S ribosomal RNA 6ztp AV 27 3.0 32820062 32630 ucauguucacauaccaaacggcgcgcg ........................... ........................... E. coli 70S-RNAP expressome complex in uncoupled state 6; mRNA 6ztp AW 77 3.0 RF00005 URS00001BBAFC_562 32820062 0030533 0006412 562 cgcggggnggagcagccuggnagcucgucgggnucauaacccgaagaucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... E. coli 70S-RNAP expressome complex in uncoupled state 6; tRNA(fmet) P-site 6ztp AX 76 3.0 RF00005 URS00005AA258_562 32820062 0030533 0006412 562 gcccgganagcucagncggnagagcaggggauugaanauccccgunnccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((.........)))).....(((((..]....)))))))))))).... E. coli 70S-RNAP expressome complex in uncoupled state 6; Phe-NH-tRNA(Phe) A-site 6ztp BA 2900 3.0 RF02540,RF02541 URS00021ED998_562 32820062 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacagacugugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugugaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccgugauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacuccuugagaguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<.>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<<.....>>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<.........>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<..<<....>>...>>>>>..>....>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<.............<<<<...<.<......<<<<<<<<....>>>>>>>>...>.>.............>>>>....>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>.(<<...<<<<<<<...<<<<<<.......>>>>>>.....<<)..(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......((((.((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))).))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((.))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((.((((.....))))..))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((.(.((.(.(.........((((...(((.......((.((((....)))).))....))).............))))).).)).).)))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). E. coli 70S-RNAP expressome complex in uncoupled state 6; 23S ribosomal RNA 6ztp BB 120 3.0 RF00001 URS0000049E57_562 32820062 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). E. coli 70S-RNAP expressome complex in uncoupled state 6; 5S ribosomal RNA 6zu1 AA 1533 3.0 RF00177,RF01959,RF01960 URS000036C8BF_562 32820062 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagcagcuugcugcuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauc ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<<....>>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((((....))))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((.(....).))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))...((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... E. coli 70S-RNAP expressome complex in uncoupled state 2; 16S ribosomal RNA 6zu1 AV 27 3.0 32820062 32630 ucauguucacauaccaaacggcgcgcg ........................... ........................... E. coli 70S-RNAP expressome complex in uncoupled state 2; mRNA 6zu1 AW 77 3.0 RF00005 URS00001BBAFC_562 32820062 0030533 0006412 562 cgcggggnggagcagccuggnagcucgucgggnucauaacccgaagaucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... E. coli 70S-RNAP expressome complex in uncoupled state 2; tRNA(fmet) P-site 6zu1 AX 76 3.0 RF00005 URS00005AA258_562 32820062 0030533 0006412 562 gcccgganagcucagncggnagagcaggggauugaanauccccgunnccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((.........)))).....(((((..]....)))))))))))).... E. coli 70S-RNAP expressome complex in uncoupled state 2; Phe-NH-tRNA(Phe) A-site 6zu1 BA 2900 3.0 RF02540,RF02541 URS00021ED998_562 32820062 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacagacugugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugugaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccgugauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacuccuugagaguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<.>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<<.....>>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<.........>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<..<<....>>...>>>>>..>....>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<.............<<<<...<.<......<<<<<<<<....>>>>>>>>...>.>.............>>>>....>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>.(<<...<<<<<<<...<<<<<<.......>>>>>>.....<<)..(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......((((.((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))).))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((.))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((.((((.....))))..))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((.(.((.(.(.........((((...(((.......((.((((....)))).))....))).............))))).).)).).)))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). E. coli 70S-RNAP expressome complex in uncoupled state 2; 23S ribosomal RNA 6zu1 BB 120 3.0 RF00001 URS0000049E57_562 32820062 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). E. coli 70S-RNAP expressome complex in uncoupled state 2; 5S ribosomal RNA 6zu5 L50 2455 2.9 RF02540,RF02543 URS00021ED916_235221 33125369 0003735 0005840 235221 caccccggugggggaucccucggccugcgcgccgggcaaggacgcggacgcacgcgauagacggcacgauccucagacacgacugccggucuccgacagcggcgcagccgcagacaaccccccggacuuaagcauaucacuagggggcggagaagaaaccaacagggauuccugcaguagcggcgagcgaacagggacgagcccgcauggcaaucggcaucgccgaguugugacagcgcaccgcgaacgccccggacagggcggccacagagggcgacagccccguagcagcgcgcagcggagcgaguagcgcugcuuggucaugcagcgcgaagcggugguggcgccaucgaaggcuaaauacgccgcaggaccgauagcgcacaaguaccgcgaggggacggcgacgagcagcccgcaggggcggcgaaagcgugaaaccaccggggcgcccacuugugggccccgucuugaaacacggaccaaggagugcaugugcgcagcgaguccgcuccgcggcgcagcgaaggccaucgagcugcgcacaugcgacccgauaggcagugaacuacgccugggcagggcgaagcccgcggaaacgcagguggaggccccgagccguucugacgugcaauucgauggcgcgaccugggcguagcggcgaaagaccaaucgaacugccugguagcugguucccuccgaaaugucccgcaggacagcgggcgccccgcaggucugccgcguagagcaauggcgcggcguccggcgccggcgcacccccaaacugcgaagcggcagggcgcgcgcagcagcgugcgcgcgcacaacugcgggcgccuagugggccgccgcugguaagcagcgccggcaaugaggacacaaccucgugcgcgggcaagggaccccagcugcgcacacagacgaagggcgcgggcgcgcccgccccgaaaauggacggugcucagcgcagccccgaccccgcgcacgcacagcgugguaggagggcgcgccggcgccgcagaagcgcaugcgugcgcaugcguggaggcacccgcggcgcagaucuugguggcaguagcacacucgggcgcgagccccgagggccgggagacggguucuuccgccaggccgcuccgcggaaggugagccggguccuaaggacgcgcuggcccgcaaccgacaggcaagcgggcacacauucccgcgccgugugccaugcggcaacgcaccgugcgcggccgggcgcagggcuggcgccgggggcccuccucccccggcggcccgccugcggacucuugcagcacgaggcagcccgcgccgccgccaggacucgccccccgugaagccccgcgcacgcacacacacgcccguaccaauccgcaccagggcuccagggcgcgcaccccacggccagggcccacgcagguuugggaauucggcaagcuggauccgcaaccucgggacaaggauuggcuccgggcgccggagcugucgcuuccaaggggaauccgacuguuuaguaaaaacauagccuugcgccgcacgcaaggugaauucugcccagugcccgggucacgccggcgcgacccgcgcacgcacgggucaacggcgggaguaacuaugacucucuuaagguagccaaacgccucgucaucuaauuagugacgcgcaugaauggagcaacgagauucccacugucccuaccugcuccccagcgaacccacugccaagggaacgggcuuggcgcagucagcggggaaagaagacccuguugagcuugacucuaguguggggccgcggccccgcuucgcgcagcaacgcccccagauggggaguuuggcuggggcggcacgucugcuagaccccaacgcagacguccuacggugggcucagcgcggacagaacccgcgcgucgagcacaagggcaaacgcccgccucacggcgcccccccgggugccggcgggaaaccggggccuagcgaucccucgcgcaugcacgccgcgucgcggggguggcugaaaaguuaccacagggauaacuggcuuguggcggccaagcguccgcagcgacgccgcuuuuugauucuucgaugucggcucuuccuagcauggcguggcagcgcgcgccaaguguuggauuguucacccacugacagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugagcggacacaccgggcagcgcgggcuaguacgagaggaacgcccgugcggggccgcugguccgcgccuguccgacagggcaggugcgccgcuacgccccgugcguguacggcuggaccucuaagccggagccgcccccccgugugucuaaacguuuccgccccccgcgaccacgacgcggccgggggcuggugcugugcgcggcgagcugcgagccgcugaggcuuccagaccccugcgggguguu ..<<<<<<<<<.....{[[..[[<<<<<<[..<......<<<<<<<((....>>>>.....<<<<<...<<.)).>>......>>>>>...>>>....<<<<<...>>>>>.>....<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<......<<.....>>.....>>>>...(((..........<<<<<...>>>>>.........<<<<...<<...<<<<<......>>>>>((......<<<.....))>>>...>>.>>>>...............<<<<<<<........>>>>>>>....<<<<<..<<<<.>>>>>..))).......].>>>>>>.]]...............<<....>>....]].........<<<<....>>>>.........}.....>>>>>>>>>.<<<<<<..>>>>>>.<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<........>>>...<<....>>......>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<.<<<....>>>.>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<<.<<<.<<<<<<<<<...<<<...<<<.<.<<<<.<<<<..>>>>>>>.>>.>>>..>>.>...>>>>>>>.<<<<<<<<<......>>>>>>>>>...>>>>>>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>...<<<<......>>>>..<<<<<<<...<<<(((...<<<<<<<...........<<<.<<<<<<..>>>>>>>>>..........))).....>>>>>>>>>>...>>>>>>><<<<...>>>>....>>>>>>..<<<.<<.<<<......<<<<<<<<....>>>>>>>>...>>>.>>.>>>........>>>>>><<.....<<...<<<<<<.......>>>>>><<<<.<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<..<<<......>>>..>>....>>...<<<<<........>>>>>))<<<<<<....<<<....>>>...<<<<<<<<..<<<.<<<<..<<<<<<.<<<<<<...[[..>>>>>><<<<<.<<.<<<<...<<.....>>......>>>>.>.>.>>>>>>>>>>>..>>.>>>>>..........>>>>>>>>.....>>>>>>>>>>..>>...<<......>>.>>>>.<<<.......>>>..>>>>.<<<.....<<<<<<..<<...............<<<<<...............>>>>><<<<<<<<...>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.......>>>>>>>...<<..<<<..<<<<<<<.<<.....<<<......>>>.....>>.>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>..>>>>>>..>>>.>>....>>...<<<<<<........>>>>>>....<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<.<<<<<..<<<<..>>>>...<<...>>.....>>>>>.>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<....>>>>>>>>.<<<....>>>.>>)))......<<<<<<<<.(((..>>>>.)))>>>>>>>>.........>>>>..]]>>>>.......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>..<<<<<<<<.<<<..<<<<<<<<...............>>>>>>>><<<<<....<<<.<<<<<<<<<<<]]..>>>>>>>>>>>..>>>..>>>>>..<<<....<<<<<.........>>>>>....>>>..>>>.>>>>>>>>.<<..>>..<<<<<<<<<<<.......>>>>>..<<<<<<<<<.<<<....<<<<<..<<.>>..>>>>>...>>>..>>>>.>>>>>..>>>>>>.. (.(((((((((.....(((..((((((((.(.(......((((((.[[....[)))...].(((((...((.]].))......)))))...)))....(((((...))))).)....((((((.....(...[..)......))))).).........((....))...((((......((.]...)).....))))...((((........((((((...)))))....)....((((...((...(((((......)))))[[(...).(((.....]])))...)).))))..........)....(((((((........)))))))....(((((..[[[[.)))))..)))......)..)))))).))...............((....))....))(.....)(.((((....))))).(....).).....))))))))).((((((..))))))[((((........))))((((((....(((((((((((((..(((........)))...((....))......)))))))))))))..((.(...((((((.....((((((((((.((((...(((.(((....))).)))...)[)))...(((..((.((........)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(((((....)))))((((((((((.(((.(((((((((...(((...(((.(..(((.((((())))))))..).)))..)).)...))))))).(((((((((.(...))))))))))...))))))))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(((((((.....(.....(((.((((((())))))))))..........]]].)...))))))))))...)))))))((((...))))....))))))(.(((.((.(((......((((((((....))))))))...))).)).)))..).....))))))((.....((...((((((.......))))))((((.((((..((..(((((((...((.....)).))))))....[[((((.((...((..(((......)))..))....))...(((((........)))))]]((((((....(((....)))...((((((((..(((.((((..((((((.((((((...{{..))))))(((((..(.((((...(.......)......)))).)...)))))))))))..)).)))))(...).....)))))))).....)))))))))).)))...((......)).)))).(((.......)))..)))).(((.....((((((..((..(....(.......(((((....(.{..).....)))))((((((((...))))))))(...).......(((((((((.].((.........))...(((((((.......))))))).}.(((.(((..(((((((.((.....(((......))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..)))..))))))..))).))....)).{.((((((.....]}.))))))...)((((..(((.((......((((.((((((..(((((.((.(((((..((((..))))...((...)).....))))).))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((...(..)))))))...).((][.[[[))....))))))).(.((((((((....)))))))))(((....))).))]]].].....(((((((.(((..]]]].))))))))))....).....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(((((((((......))))))..))).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))....))..))).))))..((((((((.(((..((((((((.....(....)....))))))))(((((...((((..((((((((((}}..))))))))))...)))).)))))..(((....((((...........))))....)))..))).)))))))).((()))..(((((((((((.......)))))..(((((((((.(((....(((((..((.))..)))))...)))..)))).)))))..)))))).. Structure of the Paranosema locustae ribosome in complex with Lso2; 25S rRNA 6zu5 L70 119 2.9 RF00001 URS00021ED963_235221 33125369 0003735 0005840 235221 agcugcggucauauccacaguagagcaccagaacccgucagaucucugaaguuaagccugugagagccuguggaguacuugggugggcgaccaccugggaaaugcagguacuguagcuu <<<<<<<<<....<<<<<<<......<<<<<..............>>>..>>.....>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>. (((((((((....(((((((......((((((...(....)...))))..)).....))))).))((((((......((.((..((....)).)).)).....))))))))))))))). Structure of the Paranosema locustae ribosome in complex with Lso2; 5S rRNA 6zu5 S60 1336 2.9 RF02542,RF01960,RF01959,RF00177 URS00000A5DB9_235221 33125369 0003735 0005840 235221 accagguugauucugccugacgugugcgcuagucuuggggacuuagccaugcaagccagcgaagcgcggagcggcggacggcucaguaggacggcgauaauccacccgcagcagagacaaggauaaccgcggcaagcugcggcuaagacauggacaggcugcggcgcggggaggcgcgggcagcggacagggagcggcugcggcggaguugcuggcccaucagcugguagguaggguaagggccuaccuaggcgacgacgggugacggggggugagagcccggaaccggagagggagccugagaaacagcucccacguccaaggacggcagcaggcgcggaacuugcccaaucccggcgggggaggcagccacaagacgucgcacggcaaaggagugcgacuggagggcaagucuggugccagcagccgcgauuccagcuccaggagcgcacaugaguguugcugcaguuaaaacguccguagucggccccgcgcugugaggaaaccgcggggcccaaggcggcgggcagcacgggagcgggggcgacaggaacggacaacggccgcgggauccgggggcgagaggugaaaaucggggaccccgcggggacgggcggaagcgaaggcggcggccggggacguguccguugaucaaggacgaaggccggaggaucaaagaugauuagauaccgucguaguuccggcaguaaacgaugccgacggggcgaggccagggggcuguguccgggagaaauuggaguguuugggcucuggggauaguacggucgcaagacagaaacuuaaagaaauugacggaaggacaccacaaggaguggagugugcggcuuaauuugacucaacgcggggcagcuuaccagggccggaugcgcagggaguggugcauggccguuugcaacacguggggugaccugucugguugauuccgacaacgcgugaggccuggggugcagcaggcugugcgacgggcggcggcaagcugcaggagggcaggcgaaaacaggucagugaugcccucagaugcucugggcugcacgcgcacuacaauggcgcggcgagcgggagugccgggaggcgcgggcgaggccguggcgcagcagggaugggggccuggaagggugcccugaacgaggaauuccuaguagccgcgggucaccaagccgcggcgaaugagucccuguucuuuguacacaccgcccgucacuaccuaagauggaugugcaggcgaggaggcugggcaggcacccgagccugugcaacuagauaagguauaagucguaacaaggcugcaguaggugaaccugcggcaggaucacua ..<<<<<.[.((((>>>>>.<<<<<<<<<..<<<<<<<<......<<<.<<<..<<<.<<...<..>...>>>>>......<<........<<<<<<<..<<<..<<<<<<<........<.....<<<<<<....>>>>>>......>........<<<<<..<<<<......>>>>.>>>>>............>>>>>>>.>>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<<<<<..........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<....>>>..>>>..>>.>>>>>>...<<<<.........>>>>..<<<<<((......<<<<.....<<..))>>....>>>>.>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<.<....<<<<.<.........>.>>>>.>..>>>>>..>>>.>>>>....<<<<<<..<..<<<<<<<..<.<<<<.<<<...<<........>>......>>>.>>>.>.>........<<....>>.>>>>>>>.>..>>>.>>>...>>>...>>>>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<<<.<<<<....>>>>.>>>>>..<<..))>>...>>.....>>>.>>>.<<........<<<....>>>......>>..)))).]<<<<<.<<<<<<<..<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<....<<..>>..<<<.<<<..<<.<<<<<<....<<.<<<<<<....>>>...<<<......>>>...>>>.>>....<<<<..<<<<<<<..>>>>>>>.....<<<<<.....>>>>>.......>>>>....>>>.>>>.....>>>>>>>>....>>>>>>>...>>.>>>>>>>>.....<.<<<<<<...<....<<<<<....>>>>>....>..>>>>>>.>...........<<<.<<<......>>>.>>>..........>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<<.<...<<.<<<<<<<<<..<<..<<<.....>>>..>>..>>>>>>>>>.>>...>.>>>>>...>.>>...>.....<<<.<<<<<....>>>>>.>>>......... ..((((..[.[[[..)))).(((((((((..(((((((((.....(((.(((..(((.((...(())...)))))......(((.......(((((((..(((..(((((((........(.....((((((....))))))......)........(((((..((((......)))).)))))...(.(...[))))))))).)))))))))).(((....(((..((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((((((..........)))))).((((....))))...)))))).).....(.(((...((((..].))).))))).)).))))))..((.(...........).)).((((([[....(.((((.....((..]]))....))))))))))..)))))))))...[......((([[...(.((((...(((.(((((((.(((((.(....((((.(.........).)))).)..)))))..))).))))...(((((((..(..(((((((.(...(((.(((...((........))......))).)))...)........((....)).))))))).)..))).)))..))))...))))....((((((....(...((((.........))))...).))))))......{...(((.((.(((((.((((....)))).)))))..((..]]))...))...].))))))).((........(((....)))......))...]]].](((((.(((((((..((..(((((..((((((((((......((........))..........(((((((....((()))..(((.(((...(.((((((....((.((((((....)))..(.((......)))...))).))....((((..(((((((..)))))))..(..(((((.....))))).....).))))....))).))).....).))))))....)))))))...)).)))))))).(...(.((((((....(...(((((....)))))...)...)))))).)......(....(((.(((......))).)))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(..(((((.(..(((.(((((((((..((..(((.....)))..))..))))))))).)))..).)))))...).))...)..)..(((.(((((....))))).)))}........ Structure of the Paranosema locustae ribosome in complex with Lso2; 18S rRNA 6zu9 2 1771 6.2 RF01960,RF01959,RF00177 URS00005F2C2D_559292 33289941 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugagcuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauu ...<<<<<.{.[[[[>>>>><<<<.<<<<<<...<.<...<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<..<<..<<....<<<..................<<....<<.<<<.....>>>.>>.....>>.........<<<<<..<<....>>..>>>>>....<<<<<<......(((((((.<<<....>>>....<........>>>>>>>.........<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>..>>>..>....>.>.....<<<<<<<<.<<<<....>>>>.>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>>.........<<<[[.....<.<<...<<<.<<....<<<<<<.<<<<<...........>.>>>>.>>>>>>.....<<<<<....................>>>>>....<<<<<.<<.......<<...<.......>..<<<<...>>>>....>>......>>.>>..>>>.........<<<..<<<<<<<<.....))))))).>>>>>>>>.>>>.....>>....<<<<<<.<<...<<<<..<<<.<<<<<<.<...<<<......>>>......>.>>>>>>.>>>.......<<....>>...>>>>..>.>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..]]>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..]]]].}<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<.<<<<.<<<<....>>>>.>>>>.>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>........ ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((.....(..........)....)){))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[[.[[[.(((....))).....(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(.(((((.(.(((....))).).)))).).)....(.(((.(...........)).))......)..((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((................))).))))))....(.((((....................)))).)...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(....(.((.(((.....]].]]]].))).)).)...).....))...((..(((.((...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)).)))...)..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.((..........))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].].((((.(((((((..((..(((((..(((.((((((.......(........)...........((((..(....(((((.....(..((.(((........))).))....).)))))...((.((....(.((((((.(..(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..))))).)..))).))).....)..)))).....)..))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).)...(.(..((.(..((((.((..(.((((((((.(((..(.((..(...((((((..((((.((((....)))).))))..))))))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>....... Structure of a yeast ABCE1-bound 48S initiation complex; 18S ribosomal RNA 6zu9 1 75 6.2 RF00005 URS00002CB170_559292 33289941 0030533 0006412 559292 agcgccgunncgcagnggaagcgcncagggcucaunacccugaunnnnucggaucgnaaccgngcggcgcuacca <<<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((....[..)))).(((((.......))))).....(((((..]....)))))))))))).... Structure of a yeast ABCE1-bound 48S initiation complex; tRNA 6zvi d 76 3.0 RF00005 URS00008FED3A_4932 32744497 0030533 0006412 4932 gcccggauagcucagucgguagagcaggggauuaggaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... ..(((((..((((........))))..((((.......))))......((.((.......)).)))))))...... Mbf1-ribosome complex; A/P-site tRNA 6zvi e 77 3.0 RF00005 URS000041AF00_4932 32744497 0030533 0006412 4932 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).((((.........))).)....(((((..]....)))))))))))..... Mbf1-ribosome complex; P/E-site tRNA 6zvi f 35 3.0 32744497 4932 uuuuuuuuuuuugacaaauuuuuuuuuuaaacugg ................................... ................................... Mbf1-ribosome complex; mRNA 6zvi h 1758 3.0 RF01960,RF01959,RF00177 URS00021ED958_4932 32744497 0003735 0005840 4932 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.{.[[[[>>>>><<<<.<<<<<<...<.<...<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<..<<..<<....<<<..................<.....<<.<<<.....>>>.>>......>.........<<<<<..<<....>>..>>>>><...<<<<<<......(((((((.<<<....>>>..............>>>>>>.....>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>....<<<..........>>>....<.<<<..>>>.>...>>>>>>.........<<<....<<<.....>>>..>>>..>....>.>.....<<<<<<<<<<<<<....>>>>>>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>>.........<<<[[.....<.<<...<<<.<<.....<<<<<.<<<<<....<<>>....>>>>>.>>>>>.......<<<<...........<.......>...........>>>>.....<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........<<<..<<<<<<<<.....))))))).>>>>>>>>.>>>.....>>....<<<<<<.<<...<<<<...<..<<<<<<.<...<<<......>>>......>.>>>>>>..>.......<<<....>>>..>>>>...>>>>>.>>>...>>>...>>.>.......<..........<<<<.<.....>.>>>>......>..............<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..]]>>...>>.....>>>.>>>.<<<......<<<......>>>....>>>..]]]].}<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>......<....<<<<<<..........>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<..........<..<...<<<<<...>>>>>...>..>..........>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[[[[[.[(((....))).....(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....))))))....(((..........)))....(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....((...((((((((....))))))))....))....(.(((.(...........)).))......)..((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((.....(((((.(.(.(.....()......).)).))))).....((.(((.........(..(.....)....).......)))).)...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(....(.((.(((....].]]]]]].))).)).)...).....))...(((..((.((...(..(..((..(.((((.....((........))........)))).)..)).......((....))...)..)..)).))...))..))))...)).)....(.(.......(...((((.........))))...)....).)......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((........((.(((........))).))......)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(.(((((.(.......(..(..(...(((((...)))))...)..)..).......).))))))..)).))))...).))...)..)..(((((((((....)))))))))>........ Mbf1-ribosome complex; 18S rRNA 6zvk e2 3920 3.49 RF02540,RF02543 URS00021ED970_9986 33296660 0003735 0005840 9986 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcggcccggcggaucuuucccgccccccguggggucggcgggggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucggggggccccgcgggaccgaaaccccccccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcgcucuccccccucccggcgcccacccggggcgcgccggcgucuccucgugggggggccgggccaccccucccacggcgcgaccgcucucccaccccucgucggggggcggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccgggggagguucucucggggccacgcgcgcgucccccgaagagggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcagacccgacgcacccccgccacgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcgugagccgggcguggaauggagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagcggcgggggcggcgcgcgcgcgcgcccgcccccggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcugggucggucgucggccggcgccuagcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacaugagagguguagaauaagugggaggcccccggcgcccccccgguguccccgcgaggggcccggggcgggguccgccggcccugcgggccgccggugaaauaccacuacucugaucguuuuuucacugacccggugaggcgggggggcgagccccgaggggcucucgcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccggucccccgccuguccccgccggcgccgcgcgccgggaccgggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcaccggccguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<<....<......>.....>>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..[[[....<<<...<<<<<<<<<<<...>>>>>>>.>>>>.....>>>....<<<<<<<<<....<<<<<<<<.<.<....<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>>.>>>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<......>>>..................................<<<<<<<<..<<<......<<<<<<<<.<<<.....<<<<<<<<<<<...<<<.....<<<<.<<....<<<<.<<<..<<<<<<<<<<..>>>>..>>>>>>>>>>>>>>>.>>>>.......>>>.>>>>>>>>>>>......>>>.>>>.>>>>>..<<<<<<<..<<<<<<<<<<.<<<....<.....<<<<.<<<<......<<<<<<<.<....<..>...........>>..>>>>>>.......>>>>.>>>>..........>.>>>...>>>>>>>>>>....................<<<<...<<<<<<<..<<<<<....<<<.>>>..>>>>>.<<......>>.>>>>>>>.....<<.<<<<.<<<<<<<<<<<<<<<<<.......<<<<.....>>>>.<<<<<<<.<<<<....>>>>.>>>>>>>>>>.>>>>>>>>>>>.>>>...>.>>>...........>.>.........<<<<<<<<.....>>>>>>>>.........>>>>.......>>.>>>>>....>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<......>>>>>>>..<<<<<...<<<..<<<...(((..[..>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...........................<<.<<<<<<<<<...<<<....<<<..<.<<<..<....<.........>...>.>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<........>>>>>>>>>...>>.>>>>>>>>>.>>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<....<<....<<.........>>....>>.......<.<<......>>.>....>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<............].)))......................................................>>>>>>>>>....>>>>>>.<<<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>.>>.....>>>>>><<<....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<<<<<...>>>>>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<...<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..{{{..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>..>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<..<<<<<<<.>>>>>>>.......>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>...>>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<<.<<<<<<.<<<...............................<<<<.<<<<<<<<.<<<<<.....>>>>>>>>>>>..>>...>>>>.......................................>>>.>>>>>>...<<<<<.....<<<<..<<.<<<<<<<..>>>>>>>>>..............<<<<<<<<<<<.....>>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>>.<<<....>>>.>>)))]......((((((..(((..>>>>>>.)))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]].....<<<<<<....<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<.}}}..>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>.....>>>>>>.....<<<<<<<.....<<<.....<<.........<<<<<..<.<<....<<<<<.<<<<<..>>>.>>...>>>>>..>>>.>>>>>........>>....<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>................>>>....>>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<.<..<<<<<......>>>>>..>>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..(((((((((((.....)))))).))))....))))....((((((.((....((((((((.(.(....((((((((..({((((......)))))....[[(...).(((....}]])))...).)))))))).)))))))))...)).))))))..)....(((((((........))))))).....(((((..[[[[.[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((......((((((((.(((.....(((((((((((...(((..(..((((.((.....(((.((...((((((((((()))))..)))))).))))).)).)))).).....))).)))))))))))......))).))).)))))..((((((((.((((.(((((.(((....(...(.((((.((((.......(((((((......()............).).)))))........)))).))))).........).)))...))))).))))....................(((((..(((((((..(((((....(((.)))..))))).((......)).)))))))..((..(.((((.((((((((((((((((........(((((...)))))..((((((.((((....)))).))))))..)).))))))))))).)))...).)))...........)..)..).....((((((((.....)))))))).....[..)))))......))).)))))....)))...)))))))).<((((........))))((((((....(((((((((((((..(((..(((((........)))).)...)))...((....))...((((((((....))))))))..(((((...(((..(((...[[[..[[.)))..)))....))))).(((((((((.((((......))))))))))).))....)))))))))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((............................(.(.((((((....(((....(((..(.(((......(...........)....))).)..)))..)).)....))))))...(((((((((........)))))))))....).).)))))))..))..((((.(((((.....))))).))))..(.(((......))).).(((((((...((([[[.....(.(((((......(..........(((.((((((((((.....{.((....(((...(...........)...))).....(...((......)).)....))...)))))))))))))..........]]].)....)))))).)))...)))))))((((((.(((..........].].]]]................]........(.....)..........(...).......)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...((....(((....)))..........((.(((((((((...)))))))))))......))....))...(((((........)))))]]((((....(((.....(((((((....)))))))..((((....)))...(...((((((...(((((((((((((((((((((....{{{....))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...))............))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((...((((((.))))))........)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((.(((.(...((.....((((....)))).....)).))))...))))).((((.........)))).........((..........((((.(......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.(((((((((.((((((((((...............................((((.((((((((.(.(((.....))).)))))))..))...)))).......................................))))))))))...(((((.....((((..(..((((((....)))))).)..............(((((((((((.....)))))))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].......((((((..(((..].]]]].)))))))))....)}....))))..)))))).......((...(.((((((...((.......))...))))))...)..).)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a.))..))).))))).....((((((..(.(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}}.)))))..)).))...))))...)))).((((...((((.....}.......))))...))))..)))...).)))))).....((((((......((......((..........(((...(.((....(((((.(((((..))).))...)))))..)))..))).........))....((..((((....((((.(((((((......)))))))))))...))))..)).................)).....))))))(((((.(..(.......)..)....((.(((((((.((.....((((.(..(((((......)))))..)))))....))....)))).))).))..))))).. The Halastavi arva virus (HalV) intergenic region IRES promotes translation by the simplest possible initiation mechanism; 28S RIBOSOMAL RNA 6zvk d2 120 3.49 RF00001 URS000002B0D5_9986 33296660 0003735 0005840 9986 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. The Halastavi arva virus (HalV) intergenic region IRES promotes translation by the simplest possible initiation mechanism; 5S RIBOSOMAL RNA 6zvk h2 156 3.49 RF00002 URS00004B2C76_9986 33296660 0003735 0005840 9986 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<.<<.....>>>.....(.<<<......>>.............>>>..)...>>>....<<....>><<<<<<<<.......>>>>>>>>.................... .........................................((((((.[[....[)))...].(.(((......]].............)))..)...)))....((....))((((((((.......)))))))).................... The Halastavi arva virus (HalV) intergenic region IRES promotes translation by the simplest possible initiation mechanism; 5.8S RIBOSOMAL RNA 6zvk E1 153 3.49 URS00021ED9A8_1088890 33296660 1088890 aaaacaugugaucuuaucacuuuuauaguuuaugaaaucuuuauuauuguuauugcuauguuuuaaauuucuuuuucaaaauucauccuguuccagcaaugguuuuaaaggaacuuguauaugaaaaccgccacuauuacaucaacaacauca .<<<<<...........<<.............(((............>>.........>>>>>...................)))....<<<<<......(((((....>>>>>..........)))))........................ ..((((.........(.((.............[[[[...........)).).......))))...................]]]].....[[[[......(((((....]]]]...........)))))........................ The Halastavi arva virus (HalV) intergenic region IRES promotes translation by the simplest possible initiation mechanism; INTERNAL RIBOSOME ENTRY SITE 6zvk K3 1869 3.49 RF01960,RF01959,RF00177 URS00005A14E2_9986 33296660 0003735 0005840 9986 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucgcuccucucccacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucagaucaaaaccaacccggucagccccucuccggccccggccggggggcgggcgccggcggcuuuggugacucuagauaaccucgggccgaucgcacgccccccguggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcgggcgggcgguccgccgcgaggcgagccaccgcccguccccgccccuugccucucggcgcccccucgaugcucuuagcugagugucccgcggggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggucggcccacggcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.{.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<...<<<..........>>>..>>.>>......<<........<<<.<....<<....<<<<<..................<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<<<....>>>>>>...>>>>....<<<<<.....((.{......<<.....<<<.<<<<<<........>>>>>>..>>>......>>.....<......>..>>>>>...........<<<<.<<<<......>>>>>>>>.>>>.>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>...<<....>>.....>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....<<.<<<.<..<........>..>..>>>..>>......<<..<...........>..>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>.>>>.........<.<[[.....<.<<...<<<.<<.....<<.<<<<<<<<.<<<<.<<<<....>>>>....>>>>.>>>..>>>>>>>........<<<<.<<<<<...<<<<<<<......>>>>>>>....>>>>>>>>>.....<<<<<<.<.......<<...<.......>.<<<<.......>>>>...>>......>.>>>..>>>.......<<....<<<<<<<...........})).>>>>>>>...>>....>>....<<<<<<......<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>.....>>>.>>>...>>>...>>.>....<<<<<<....<...<<<<.<.....>.>>>>...>.>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<........>>>>>>>>>.>..>>>...<<..]]>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).}<<<<<.<<<<<<...<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<<...........<<........>>.........>>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<.....<<.<..<<......>>>..>>.....>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<.<<<................<<<.<<<<....>>>>.>>>..............>>>.>>..........<.<<<<<..........>>>>>>..........>>>>>.....<<<<<<<<.......>>>>>>>>......>>....>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<<<<<<<<<<<<<.......>>>>>>>>>>>.>.>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[..[[..))))(((.((((((.....((..((.....(((.(((........((....((..........))...)){........(((.......(((.(....(.....(((((...................(.....((.(((.....))).))......)..........((((...(((((......)))))...))))....(((((......[[[.[....(((....((((.(.((..........)).).).)))...)..)).....(......)..)))))...........((((.(.(((...).)).))))).))).))....)..).))).(((......(....(((((((.........))))))))........)))...(((.((((....))))....)))))).((.(((..........))).))...((....)).....)))))).).....(.((.(....((.}...))...)))).)...)).......((.(.(..(.............)..).)..))......((..(............).)).........((((([[......((((.....((..]])).......)))).)))))..)))))).)))..{......(.(.{...(.(.((...(((..(....(((..(((((((..(((.((((....))))....)))..)))..)))).))).......((((..(((....((..(((......)))..)).....))).)))).....((((((.(.......((..((.......)).(((.......)))....))......).)))..))).......((....(.((((..........].]]]..)))).)...))....)....(((.((.(.(...((((..(((.((((((((...((........))......)))))))).))).......(......)...))))..)..)))..))..))))...)).)....(((((.....(...((((.........))))...)..)))))......<...(((.((.(((....((.(((....(......)...))).).)...)))...((..}.))...))...}.))))).).(((......((((....))))....)))...]]..](((((.((((((...(...(((((..(((..(((((.......(........)............((((.(....(..((............((........))..........))..)...((.(((......(((((....(((.((.((....))...(.((......)))...)).)))....(((.......(.((..((......((.(..((......)))..))......))..)).).....(..(((((.....)))))....)...)))....))).))........))))).....).))).)...)).)))..))).(...((.(((................((...(((....)))...))..............))).))......(.....(((((..........))))).....)..)..))))).....((.((.((.......)).)).)).......)....))))))))).))..(.(..((....((((.((..(.((((.(((.(((..((((.((...((((((.((((((((.((.....)).))))))))..).)))))...)).))))..))).))).)))))..)).)))).....))...)..)..(((((((((....)))))))))>........ The Halastavi arva virus (HalV) intergenic region IRES promotes translation by the simplest possible initiation mechanism; 18S RIBOSOMAL RNA 6zym 2 27 3.4 RF00004 URS00003EE995_9606 33007253 0045131 0000348 0005686 9606 uggcuaagaucaaguguaguaucuguu ........................... ........................... Human C Complex Spliceosome - High-resolution CORE; U2 snRNA 6zym 5 74 3.4 RF00020 URS0000118C49_9606 33007253 0000244,0000353 0005682,0046540 9606 cucugguuucucuucagaucgcauaaaucuuucgccuuuuacuaaagauuuccguggagaggaacaacucugag <<<...<<<<<<<<<<........<<<<<<<<...........>>>>>>>>...>>>>>>>>>>.......>>> (((....(((((((((....(...((((((((.(.......).)))))))).).)))))))))........))) Human C Complex Spliceosome - High-resolution CORE; U5 snRNA 6zym 6 79 3.4 RF00026 URS00007199F9_9606 33007253 0030621 0000244,0000353 0005688,0046540 9606 gugcucgcuucggcagcacauauacuaaaauuggaacgauacagagaagauuagcauggccccugcgcaaggaugacac <<<<<.<<....>>>>>>>.....................................<<...<<<.....>>>....>>. (((((.((....))))))).....................................((..((((.....)))..).)). Human C Complex Spliceosome - High-resolution CORE; U6 snRNA 6zym Y 41 3.4 33007253 9606 guaagagccuagcauguagaaaugaugucauacuuauccug ......................................... ......................................... Human C Complex Spliceosome - High-resolution CORE; pre-mRNA 6zym Z 13 3.4 33007253 9606 cggccuccgaacg ............. ............. Human C Complex Spliceosome - High-resolution CORE; pre-mRNA 7a01 E1 153 3.6 URS00021ED9A8_1088890 33296660 1088890 aaaacaugugaucuuaucacuuuuauaguuuaugaaaucuuuauuauuguuauugcuauguuuuaaauuucuuuuucaaaauucauccuguuccagcaaugguuuuaaaggaacuuguauaugaaaaccgccacuauuacaucaacaacauca .<<<<<...........<................((............>.........>>>>>..................))......[.(((......<<<<.....))).]...........>>>>........................ ..((((...........((............[.[.............)).........)))).....................].]....((((......[[[[.....))))............]]]]........................ The Halastavi arva virus intergenic region IRES promotes translation by the simplest possible initiation mechanism; INTERNAL RIBOSOME ENTRY SITE 7a01 e2 3825 3.6 RF02540,RF02543 URS00021ED9BA_9986 33296660 0003735 0005840 9986 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcggcccggcggaucuuucccgccccccguggggucggcgggggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucggcccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcgcucuccccccucggcgucuccucgugggggggccgggccaccccucccacggcgcgaccgcucucccaccccucgucggggggcggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccgggggagguucucucggggccacgcgcgcgucccccgaagagggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcagacccgacgcacccccgccacgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcgugagccgggcguggaauggagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagcggcgggggcggcgcgcgcgcgcgcccgcccccggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcugcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacaugagagguguagaauaagugggaggcccccggcgcccccccgguguccccgcgaggggcccggggcgggguccgccggcccugcgggccgccggugaaauaccacuacucugaucguuuuuucacugacccggugaggcgggggggcgagccccgaggggcucucgcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccggucccccgccgggaccgggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcaccggccguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..[[[...<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>...<<<<<<<<<....<<<<<<<<........<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>...>>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<......>>>....................................<<<<<...<<<......<<<<<<<<.<<<.....<<<<<<<<<<<...<<<.<<.<<<<<.<<...<<<<<.<<..<<<<<<<<<<<..>>>>..>>>>>>>>>>>>>>>>>>>>>>>....>>>.>>>>>>>>>>>......>>>.>>>.>>>>>..<<<<<<<<.<<<<<<<<<..<<<....<.....<<<<.<<.<...<...<<<<<.>>>>>...>.....>>>.>>>>..........>.>>>....>>>>>>>>>....................<<<<<..<<<<<<................>>>>>>....<<<.<<<<.<<<<<<<<<<<<<<<<........<<<<.....>>>>..<<<<<<.<<<<....>>>>.>>>>>>..>>.>>>>>>>>>>>.>>>...>.>>>...........>>.>...........<<.<........>>>...........>>>>>......>>>.>>>>>....>>>....>>>>>....<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<......>>>>>>>..<<<<<...<<<..<<<...(((..[[.>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>(><<.<<<<<<<..............................<<<<<<<<....<<<....<<<..<.<<<..<.<..............>.>.>>>.>..>>>..>.>>....>>>>>>...<<<<<<<<<........>>>>>>>>>...>>...>>>>>>>..>>).<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<......<..........<<<.<<<<<<<<<<.......<<<...<<<...................>>>.........<<......>>.....>>>...>>>>>>>>>>>>>..........))).>....>>>>>..>>>...>>>>>>><<<<<<.<<<..........]]..)))......................................................>>>>>>>>>....>>>>>>.<<<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>.>>.....>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<<<<<...>>>>>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<....<<<<<<......>>>>>>...<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..{{{..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>..>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<..>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>>.<<<<.........>>>>.........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<<.<<<<<<<<<<.....<..............<.........<<<<<<<<.<<<<...<.<........>>..>>>.>..>>>..>>>>>........................>......>......>>>>>>>>>>...<<<<<.....<<<<...<.<<<<<<....>>>>>>>...............<<<<<<<<<<<.....>>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))]......((((((..(((..>>>>>>.)))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>........<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>.....<<<<<<<....>>>.>>>>....}}..}}}.]]]]].....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<.}}}..>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.....<<<<<<<.<<..<<<.....<<.........<<<<<..<<.<<.......>.>>>.>>>>>........>>....<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>................>>>..>>>>>>>>><<<<<....................<<.<<<<<<<.<<.....<<<<....<<<<<......>>>>>...>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..(((((((((((.....)))))).))))....))))....((((((.((....((((((((.(......((((((((..({((((......)))))....[[(...).(((....}]])))...).)))))))..)))))))))...)).))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).......................(((((...(((......((((((((.(((......((((((((((...(((.((..((((.((...(((((.(((..((((((((((..))))..)))))))))))))))))))).))....))).)))))))))).......))).))).)))))..((((((((.((((.(((((.(((....(...(.((((.(.((.....(.(((((.))))))........))).))))).........).)))...))))).))))....................((((...((((((.....(......)...))))))..((.((.((((.((((((((((((((((........(.(.(...).).)..((((((.((((....)))).))))))..)).))))))))))).)))...).)))...........)).)..)........((..(.....)..))............))))......))).)))))....)))....))).))..[((((........)))).(((((.....((((((((((((..(((..(((((........)))).)...)))...((....))...(((.((((....)))).)))..(((((...(((..(((....[[...[.)))..)))....))))).((((..(((.(((((...).)))))))..)).))....))))))))))))...((.(...((((((.....(((((((((..((.(....((((((....))))))....)<.))...(((..((.((.......A)))).)))....))))))))).(..(.......)....)..))))))......).))..((((((....(.(((....))).)((.(((((((.............(........).....(.(.((((((....(((....((...(.((((.(.(.(...........)).))))).)...))..)).)....))))))...(((((((((........)))))))))....).).)))))))..))..((((.(((((.....))))).))))..(.(((......))).).(((((((....(([[[...(.(.(((((......(..........(((.((((((((((.....{.((((...((...(...........)...))......(...((......)).).).)))...)))))))))))))..........]]].)....)))))))))....)))))))((((((.(((..........]...]].......................................................)))))))))....)))))).(.((((((((.((.......(((.((((....)))))))....))))))))))..).....))))).((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...((....(((....)))..........((.((((((((.....))))))))))......))....))...(((((........)))))]]((((....(((.....((.((((....)))).))..(((.(...)))...(...((((((...(((((((((((((((((((((((..{{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....(((.((((....).))).))))))).).)))))))))))).........))))))...))............))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....((((((..((..(....(.......(((((....(.[..).....)))))((.((((((((((..))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((..((..((.(((.(...((.....((((....)))).....)).))))...)))).(.(((.........)))..).......((..........(((...........)))..)..)....)))....)).))))))).)..)))..))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.(((((((((.((((((((((.........................(.....(..(.((.((.(..(.(.(.....).)..)).).)..))...)..)...........)...........................))))))))))...(((((.....((((.....((((((....))))))................(((((.(((((.....))))).)))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(.(((.((((.....{...))).)))))(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a.))..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....(.(.....((.(((((((}}}.)))))..)).))....).)...)))).((((...((((.....}.......))))...))))..)))...).)))))).....((((((..((..((.(....((..........((((..((.(.(.......)))).)))).........))....((..((((....((((.(((((((......)))))))))))...))))..))................)))..)).))))))(((((....(.......).......((.(((((((.((.....((((.(..(((((......)))))..)))))....))....)))).))).))..))))).. The Halastavi arva virus intergenic region IRES promotes translation by the simplest possible initiation mechanism; 28S RIBOSOMAL RNA 7a01 h2 156 3.6 RF00002 URS00004B2C76_9986 33296660 0003735 0005840 9986 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<.<<.....>>>.....(.<<<......>>.............>>>..)...>>>....<<<..>>><<<<<<<<.......>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))((((((((.......)))))))).................... The Halastavi arva virus intergenic region IRES promotes translation by the simplest possible initiation mechanism; 5.8S RIBOSOMAL RNA 7a01 d2 120 3.6 RF00001 URS000002B0D5_9986 33296660 0003735 0005840 9986 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<<............>>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (.(((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))).).. The Halastavi arva virus intergenic region IRES promotes translation by the simplest possible initiation mechanism; 5S RIBOSOMAL RNA 7a01 K3 1801 3.6 RF01960,RF01959,RF00177 URS00021ED988_9986 33296660 0003735 0005840 9986 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucgcuccucucccacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucagaucaaaaccaacccggucagccccuggcgggcgccggcggcuuuggugacucuagauaaccucgggccgaucgcacgccccccguggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcgggcgggcgcgcccguccccgccccuugccucucggcgcccgggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggucggcccacggcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.{.[[[[>>>>><<<.<<<<<<...<.<<.........<<<.<<<...<....<......<..........>.....>.>.......<<........<<<......<<......<....................<<.....<<.............>>......>>.........<<<<...<<<<<......>>>>>...>>>>....<<<<<......(((((......<....<<.......>>......>................>>>>>...........<<<<..<<<......>>>.>>>>...>......>>....>>>.<<<....<<<.....<<<<<<.........>>>>>>.>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>..>>>......>>.>.....<<.<<<<<<.<........>.>>.>>>>..>>....<.<<.................>>......>..<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<[[.....<.<<....<<.<<.....<<.<<<<<<<<<<..>>>>>..>>>>>>>........<<<<.<<<<>>>>>>>>.....<<<<<<.<.......<<...<.......>..<<<.......>>>....>>......>.>>>..>>>........<.....<<<.<.........)))))...>.>>>.....>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...>>....>>.>....<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<..]]>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..]]]].}<<<<<.<<<<<<<..<<..<<<<...<<<.<<<<<<.......<........>...........<<<<<.<....<<<<<........<<..<<........>>.>>.......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<......>>...<<<......>>>...>>.>>>....<<<.......<<.....<<.....<<.<<..<......>>>..>>.....>>.....>>........<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<.<<<................<<<.<<<<....>>>>.>>>..............>>>.>>......<.....<<<<<..........>>>>>.....>......>>>>......<<<<<<<.......>>>>>>>.......>>...>>>>>>>>>>.>>.......<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<.<<<<<<<..<.........>..>>>>>>>...>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>.........<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))(((.((((.(...(.((..((.....(((..((..((....((....((..........))...)){))......(((.......(((.(....((....(.(.(..................((.....((...(.....)...))......)).........((((...(((((......)))))...)))).....((((......[[[[[....(.(....((.(())..))......)).....(......)..)))).............(((.(((........))))))..)..).)....)).).))).((.....(((....(((((((.........)))))))))).......))...(((.(((......)))....)))))).((.(((..........))).)).(.((....))..)..)).))).).....(.(((...((((.}...))).))))).)...)).).....((.(.(((..(........)..).)).)..))......((..(...........)..)).........((((([[....(.((((.....((..]])).......))))))))))..).)))).)))..{......(.({{.....(.((....((..(....(.(.(((((((((.().))))..)))))).).......((((.(((()))))))).....((((.(.(.......((..(.........).(((.......)))....))......).).)..))).......((....(...(..........]]]]]....)...)....).)..)....(((.(.(..(...((((..((..((((((((...((........))......))))))))..)).......((....))...))))..)..).)..))..)))....)).)....((((((....(...((((.........))))...).))))))...........((.((.(((..(.((((((.((.(......).)))))))).)..)))....((.}}))...))...}.))..).).(((......((((....))))....)))...]]].](((((.(((((((...(..((((...(((.((((((.......(........)...........(((((.(....(((((............((........))..........)))))....(.((....(..(((((....(((.(((((....)))..(.((......)))...)).)))....(((.......((.(..(((...(.((.((..(......)))..)))....)))...))).....(..(((((.....)))))....)...)))....))).))......)..)))......).)))))...)).)))).))).(....(.(((........(.......((..((((....))))..))....).........))).).......(.....(((((..........))))).....)..)...)))).....(..(((.(.......).)))..)......)....)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((.((...((((..(((((((..(.........)..)))))))....))))...)).)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))......... The Halastavi arva virus intergenic region IRES promotes translation by the simplest possible initiation mechanism; 18S RIBOSOMAL RNA 7a09 2 1721 3.5 RF01960,RF01959,RF00177 URS00021ED965_9606 33289941 0003735 0005840 9606 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucguacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgccgcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcgggcgggcgguccgccgcgaggcgagccaccgcccguccccgcccucucggccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgaccggucggcguaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggugcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguagguaaaccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<....<<....<<<<<.........<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<<.....>.>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<.>>>>>>>.>>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>...<<....>>.....>>>>>>.........<<<....<<<.....>>>..>>>..>...>>.>.....<<<<<<<<<.<........>..>>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<.....<<.<.<<<<<<<<<<<.<<<<....>>>>....>>>>>>>>>>>>..>>...<......>.....<<<<<<.<.......<<...<.......>.<<<<.>>>>...>>......>.>>>..>>>........<.<<.<<<<<..................>.>>>>.>>.>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<<....>>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<.<<<<<<..>>>.>>>.>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<...<.<<<<<..........>>>>>>....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<.<.................>....>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>.........<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..((....((((....(([...((.....((.(((.....))).))......))......)).((((...((((........))))...))))((..(.(((...(......)..))).)......)).(]((((.((...))))))).).)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((........))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).).....(((((((((.............)))))).)))....(.((..(...........)..))......)..((((([[....(.((((.....((..]])).......))))))))))..)))))).)))..[......(.([[...(.(.((...(((.........(.(.((.((((((((.((((....))))....)))))))).)).).)....(......).....((.(((.(.......((..((.......)).(((.)))....))......).)))...))........(.((.((((.....................)))).)).).........(((..((..(...(((...((..((((.((....((........)).......)).))))..)).......((....))....)))..)..))...))..))))...)).)....(((((.....(...((((.........))))...)..)))))......{...(((.((.(((....((((((.((((......))))))))))....)))...((..]]))...))...].))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.(..(((......((........))...........((.(.(....(((((........((..((........))..))......)))))....(.(((...(..(((((....(((.((.((....))...(.((......)))...)).)))....(((...(...((((..(((..((((((()))).)))..)))..))))..).....(((((.....)))))........)))....))).))......).))))......).).))....)).)..).))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..(.((.((..(.(((..(((.(((..((((.((...((...((.......(....).....)...)..))...)).))))..))).)))..))))..)).)).)...).))...)..)..(((((((((....)))))))))}........ Structure of a human ABCE1-bound 43S pre-initiation complex - State III; 18S ribosomal RNA 7a09 f 75 3.5 RF00005 URS00021ED8FE_9606 33289941 0030533 0006412 9606 agcagaguagcgcagcggaagcgugcugggcccauaacccagaggucgauggaucgaaaccauccucugcuacca .<<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((....[..)))).(.(((.......))).).....(((((..]....)))))))))))..... Structure of a human ABCE1-bound 43S pre-initiation complex - State III; tRNA 7a0r X 2730 3.3 RF02540,RF02541 URS0002311992_243230 34417608 0003735 0005840 243230 ggucaagauaguaaggguccacgguggaugcccuggcgcuggagccgaugaaggacgcgauuaccugcgaaaagccccgacgagcuggagauacgcuuugacucggggauguccgaauggggaaacccaccucguaagagguauccgcaaggaugggaacucagggaacugaaacaucucaguaccugaaggagaagaaagagaauucgauuccguuaguagcggcgagcgaacccggaucagcccaaaccgaaacgcuugcguuucgggguuguaggaccaucaagccgaaguggcuggaaagcuacaccucagaaggugagaguccuguaggcgaacgagccugaguaggucguuguucgugaaacgaugacugaauccgcgcggaccaccgcgcaaggcuaaauacucccagugaccgauagcgcauaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaagagaaccugaaaccguggacuuacaagcagucauggcaccuuaugcguguuauggcgugccuauugaagcaugagccggcgacuuagaccugacgugcgagcuuaaguugaaaaacggaggcggagcgaaagcgaguccgaauagggcggcauuaguacgucgggcuagacucgaaaccaggugagcuaagcaugaccagguugaaacccccgugacagggggcggaggaccgaaccggugccugcugaaacagucucggaugaguuguguuuaggagugaaaagcuaaccgaaccuggagauagcuaguucuccccgaaauguauugagguacagccucggauguugaccauguccuguagagcacucacaaggcuaaaaccuuaugaaacuccgaaggggcacgcguuuaguccgggagugaggcugcgagagcuaacuuccguagccgagagggaaacaacccagaccaucagcuaaggucccuaaaugaucgcucagugguuaaggaugugucgucgcauagacagccaggagguuggcuuagaagcagccacccuucaaagagugcguaauagcucacuggucgagugacgaugcgccgaaaaugaucggggcucaagugaucuaccgaagcuauggauucaacucgcgaagcgaguugucugguaggggagcguucaguccgcggagaagccauaccggaaggagugguggagccgacugaagugcggaugccggcaugaguaacgauaaaagaagugagaaucuucuucgccguaaggacaaggguuccuggggaagggucguccgcccagggaaagucgggaccuaaggugaggccgaacggcgcagccgauggacagcaggucaagauuccugcaccgaucauguggagugauggagggacgcauuacgcuauccaaugccaagcuauggcuaugcugguugguacgcucaagggcgaucgggucagaaaaucuaccggucacaugccucagacguaucgggagcuuccucggaagcgaaguuggaaacgcgacggugccaagaaaagcuucuaaacguugaaacaugauugcccguaccgcaaaccgacacagguguccgagugucaaugcacuaaggcgcgcgagagaacccucguuaaggaacuuugcaaucucaccccguaacuucggaagaagggguccccacgcuucgcguggggcgcagugaauaggcccaggcgacuguuuaccaaaaucacagcacucugccaacacgaacaguggacguauagggugugacgccugcccggugccggaaggucaaguggagcggugcaagcugcgaaaugaagccccggugaacggcggcuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaggcguaacgaucugggcgcugucucaacgagggacucggugaaauugaauuggcuguaaagaugcggccuacccguagcaggacgaaaagaccccguggagcuuuacuauagucuggcauugggauucggguuucuagaaacuuggauuucuaaccugaaaaaucacuuucggggaccgugcuuggcggguaguuugacuggggcggucgccucccaaaauguaacggaggcgcccaaaggucaccucaagacgguuggaaaucgucuguagagcgcaaagguagaagguggcuugacugcgagacugacacgucgagcagggaggaaacucgggcuuagugaaccggugguaccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagaguccauaucggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgcuacgggcgcaggagaauugaggggaguugcuccuaguacgagaggaccggagugaacggaccgcuggucucccugcugucguaccaacggcacaugcaggguagcuauguccggaacggauaaccgcugaaagcaucuaagcgggaagccagccccaagaugaguucucccacuguuuaucagguaagacucccggaagaccaccggguuaagaggccaggcgugcacgcauagcaauguguucagcggacuggugcucaucagucgaggucuugacca <<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.[...((.>>>.....<<<<<<...<<.))...]..>>......>>>>>>...>>>....<<<....>>><<<<<....>>>>><<<<....>>>>>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<......<<.....>>.....>>>>...<<<....<<<<<.<<....>>.>>>>>......<<<....<<..<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>....>>.>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>..............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<.......>>>>>>>>>>...<.<........>.>.<<<<<<....<<<.<<<<<<<<<<..<<<...<<<....>>>...>>>...<<....>>...<<......>>.........>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<.....<<<<<......>>>>>......>>>...<<<<.<.<<........>>.>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<...<<<<.<<<<<<...<<<...<<<.<<<<......>>>>.>>>..>>.>...>>>>>>.>.>>>..>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<......<.<<<<<.<<<..<<<<.......>>>>..>>>.........<<......>>...>>>>>.>..>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><..<<<<<<<<...>>>>>>>>..>....>>>>>><.<<<<<<<.<<......<<<<<.<<....>>.>>>>>...>>.>>>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<<..>>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<...<<...<<<<....<<<<..<<<..<<<<<.<<<<.<<...[[....>>>>>><<<<<<<.<<..<<<<<<<<<<...<<.....>>.>>>>>>....>>>>..>>>>>>>>>...<<<<<....>>>>>....>>>>>...>>>...>>>>.........>>>>...>>......>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<<<...>>>>>>>>............<<<<<<<<<..<<...........>>..<<<<<<<.....<<<.....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>>..........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<>>>>>>>>>>>>>>>...<<<<<<.......>.>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<.<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>..>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.]].>>>>>>...>>>>>...>>>>.>>>>>....<<....<<<<<...........>>>>>....>>..>>>>.......>>>>>>>..<<<.....>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>>>. 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50S Deinococcus radiodurans ribosome bounded with mycinamicin I; RNA (2730-MER) 7a0r Y 120 3.3 RF00001 URS000231199C_243230 34417608 0003735 0005840 243230 acccccgugcccauagcacuguggaaccaccccaccccaugccgaacugggucgugaaacacagcagcgccaaugauacucggaccgcagggucccggaaaagucggucagcgcgggggu <<<<<<<<<<.....<<.<<<<<....<<<<<<<.............>>>>..>>>...>>>>>..>><<<.......<<.<<<<<....>>>>>.>>.......>>>..>>>>>>>>>> ((((((((((.....((.(((((....((((((....(.....)....)))..)))...)))))..))(((.......((.(((((....))))).)).......)))..)))))))))) 50S Deinococcus radiodurans ribosome bounded with mycinamicin I; RNA (120-MER) 7a0s X 2699 3.22 RF02540,RF02541 URS0002311A26_243230 34417608 0003735 0005840 243230 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<<<<<<<<......<<<<<<<<<<<....<<<..<<<<<<<<<<<<......<<<<<<.[...((.>>>.....<<<<<<...<<.))...]..>>......>>>>>>...>>>....<<<....>>><<<<......>>>><<<<....>>>>>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<......<<.....>>.....>>>>...<<<....<<<<<<<<....>>>>>>>>......<<.....<<..<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>....>>...>>.....<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>..............<<....>>....>>.........<<<<....>>>>.............>....>>>>>>>>>>>.......<<<<<<<<<<.......>>>>>>>>>>...<.<........>.>.<<<<<<....<<<.<<<<<<<<<<..<<<...<<<....>>>...>>>...<<....>>...<<......>>.........>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<.....<<<<..>>>>......>>>...<<<<.<.<<........>>.>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<...<<<..<<<<<<...<<<...<<<.<<<<......>>>>.>>>..>>.>...>>>>>>...>>>..>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<.....<<.......>>.....>>..........<......>....>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><..<<<<<...>>>>>..>....>>>>>><<<<<<<<<.<<......<<<<<.<<....>>.>>>>>...>>.>>>>>>>.>>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<<..>>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<...<<...<<<<....<<<<..<<<..<<<<<.<<<<.<<...[[....>>>>>><<<<<<<.<<..<<<<<<<<<<...<<.....>>.>>>>>>.>>>>..>>>>>>>>>...<.>....>>>>>...>>>...>>>>.........>>>>...>>......>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<<<.>>>>>>>>............<<<<<<<<<..<<...........>>..<<<<<<<.....<<<.....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>>...........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<.<<<<......>>>>.>>>>>>>...<<<<<<.......>>.>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<.<.<<.......>>..>>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.]].>>>>>>...>>>>>...>>>>.>>>>>....<<....<<<<.............>>>>....>>..>>>>.......>>>>>>>..<<..>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>>>. ((((((((......((((((((((.....(((..(((.((((((((......((((((.[...[[.))).....((((((...((.]]...]..))......))))))...)))....(((....)))(((((....)))))((((....))))))...((((((.....(...[..)......))))).).........((....))...((((......((.]...)).....))))....(((...((((.(........).))))....{.(((....((..(((...(((((......)))))[[(...).(((.....]])))...)))....))..))))....((((((((..[......))))))))....}.(((((].[[[[)))))..)).......)).)))).).))..............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.[..).)))))))))).<.(.(........).).((((((....(((.((((((((((..(((...(((....)))...)))...((....))...((......)).........)))))))))))))..((.(...((((((.....((((((((((.((((....((((()))))....)<)))...(((..(.((........)).).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((..(((((.((((((...(((...(((.((((......)))).)))..)).)...)))))).).))).)))))))).))..(((((((.((......)).)))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((.((((.............(.(...(............)...))..........(......)............)))).))))).))..........]]].)....))))))))))...)))))))(..(((((...)))))..)....))))))(.(((((((.((......(((((.((....))])))))...)).)))))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((((((...((...((((....(((((.(((..(((((.((((.((...{{....))))))(((((((.((..((((((((((...((.....)).)))))).))))..)))))))))...(.)....)))))...)))..)))))(..).....))))...))......))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.[..).....)))))((((((((.))))))))(...).......(((((((((.>.(...........)...(((((((.....(((.....))).......))))))).]((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))...........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).[..(((((.....>].)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(....(..(..(.......).)...)...)...((((((.......)).))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....((((.((....))..))))....)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))....((....((((.............))))....))..))))..]....)))))))(.((..))....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))...))))))))). 50S Deinococcus radiodurans ribosome bounded with mycinamicin I; RNA (2732-MER) 7a0s Y 122 3.22 RF00001 URS000080E04E_243230 34417608 0003735 0005840 243230 cacccccgugcccauagcacuguggaaccaccccaccccaugccgaacugggucgugaaacacagcagcgccaaugauacucggaccgcagggucccggaaaagucggucagcgcggggguu ..<<<<<<<<<.....<<.<<<<<....<<<<<<<.............>>>>..>>>...>>>>>..>><<<.......<<.<<<<<....>>>>>.>>.......>>>..>>>>>>>>>.. .((((((((((.....((.(.(((....(((.((....(.....)....))...)))...))).)..))(((.......((.(((((....))))).)).......)))..)))))))))). 50S Deinococcus radiodurans ribosome bounded with mycinamicin I; RNA (122-MER) 7a18 X 2699 3.4 RF02540,RF02541 URS00023119F0_243230 34417608 0003735 0005840 243230 ggucaagauaguaaggguccacgguggaugcccuggcgcuggagccgaugaaggacgcgauuaccugcgaaaagccccgacgagcuggagauacgcuuugacucggggauguccgaauggggaaacccaccucguaagagguauccgcaaggaugggaacucagggaacugaaacaucucaguaccugaaggagaagaaagagaauucgauuccguuaguagcggcgagcgaacccggaucagcccaaaccgaaacgcuugcguuucgggguuguaggaccaucaagccgaaguggcuggaaagcuacaccucagaaggugagaguccuguaggcgaacgagcccugaguaggucguuguucgugaaacgaugacugaauccgcgcggaccaccgcgcaaggcuaaauacucccagugaccgauagcgcauaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaagagaaccugaaaccguggacuuacaagcagucauggcaccuuaugcguguuauggcgugccuauugaagcaugagccggcgacuuagaccugacgugcgagcuuaaguugaaaaacggaggcggagcgaaagcgaguccgaauagggcggcauuaguacgucgggcuagacucgaaaccaggugagcuaagcaugaccagguugaaacccccgggggcggaggaccgaaccggugccugcugaaacagucucggaugaguuguguuuaggagugaaaagcuaaccgaaccuggagauagcuaguucuccccgaaauguauugagguacagccucggauguugaccauguccuguagagcacucacaaggcuaaaaccuuaugaaacuccgaaggggcacgcguuuaguccgggagugaggcugcgagagcuaacuuccguagccgagagggaaacaacccagaccaucagcuaaggucccuaaaugaucgcucagugguuaaggaugugucgucgcauagacagccaggagguuggcuuagaagcagccacccuucaaagagugcguaauagcucacuggucgagugacgaugcgccgaaaaugaucggggcucaagugaucuaccgaagcuauggauucaacucggaguugucugguaggggagcguucaguccgcggagaagccauaccggaaggagugguggagccgacugaagugcggaugccggcaugaguaacgauaaaagaagugagaaucuucuucgccguaaggacaaggguuccuggggaagggucguccgcccagggaaagucgggaccuaaggugaggccgaacggcgcagccgauggacagcaggucaagauuccugcaccgaucauguggagugauggagggacgcauuacgcuauccaaugccaagcuauggcuaugcugguugguacgcucaagggcgaucgggucagaaaaucuaccggucugccucagacguaucgggagccgaaguuggaaacgcgacggugccaagaaaagcuucuaaacguugaaacaugauugcccguaccgcaaaccgacacagguguccgagugucaaugcacuaaggcgcgcgagagaacccucguuaaggaacuuugcaaucucaccccguaacuucggaagaagggguccccacgcugcguggggcgcagugaauaggcccaggcgacuguuuaccaaaaucacagcacucugccaacacgaacaguggacguauagggugugacgccugcccggugccggaaggucaaguggagcggugcaagcugcgaaaugaagccccggugaacggcggccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaggcguaacgaucugggcgcugucucaacgagggacucggugaaauugaauuggcuguaaagaugcggccuacccguagcaggacgaaaagaccccguggagcuuuacuauagucuggcauugggauucggguuucuagaaacuuggauuucuaaccugaaaaaucacuuucggggaccgugcuuggcggguaguuugacuggggcggucgccucccaaaauguaacggaggcgcccaaaggucaccucaagacgguuggaaaucgucuguagagcgcaaagguagaagguggcuugacugcgagacugacacgucgagcagggaggaaacucgggcuuagugaaccggugguaccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagaguccauaucggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgcuacgggcgcaggagaauugaggggaguugcuccuaguacgagaggaccggagugaacggaccgcuggucucccugcugucguaccaacggcacaugcaggguagcuauguccggaacggauaaccgcugaaagcaucuaagcgggaagccagccccaagaugaguucucccacugaagguaagacucccggaagaccaccggguuaagaggccaggcgugcacgcauagcaauguguucagcggacuggugcucaucagucgaggucuugacca <<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<<((..((>>>>.....<<<<<<...<<.))..))..>>......>>>>>>...>>>....<<<....>>><<<<......>>>><<<<....>>>>>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<......<<.....>>.....>>>>...<<<....<<<<<<<<....>>>>>>>>......<<<....<<..<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>....>>..>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>..............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<.......>>>>>>>>>>...<............>.<<<<<<....<<<.<<<<<<<<<<..<<<...<<<....>>>...>>>...<<....>>...<<......>>.........>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<.....<<<<..>>>>......>>>...<<<..<.<<........>>.>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<...<<<<.<<<<<<...<<<...<<<.<<<<......>>>>.>>>..>>.>...>>>>>>.>.>>>..>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<.....<.........>.....>>..........<......>....>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><..<<<<<...>>>>>..>....>>>>>><.<<<<<<<.<<......<<<<<.<<....>>.>>>>>...>>.>>>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<<..>>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<...<<...<<<<....<<<<..<<<..<<<<<.<<<<.<<...[[....>>>>>><<<<<<<.<<..<<<<<<<<<<...<<.....>>.>>>>>>.>>>>..>>>>>>>>>..........>>>>>...>>>...>>>>.........>>>>...>>......>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<....<....>.....>>>>><<<<<<<<.>>>>>>>>............<<<<<<<<<..<<...........>>..<<<<<<<.....<<<.....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>>...........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<..<<<......>>>..>>>>>>>...<<<<<<.......>>.>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.]].>>>>>>...>>>>>...>>>>.>>>>>....<<....<<<<<...........>>>>>....>>..>>>>.......>>>>>>>..<<..>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>>>. .(((((((......((((((((((.....(((..(((.((((((((......((((((.[...[[.))).....((((((...((.]]...]..))......))))))...)))....(((....)))(((((....)))))((((....))))))...((((((.....(...[..)......))))).).........((....))...((((......((.]...)).....))))...((((...((((((........))))))....{.(((....((..(((...(((((......)))))[[(...).(((.....]])))...)))....))..))))....((((((((..[......))))))))....}.(((((].[[[[)))))..)))......)).)))).).))..............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.[..).)))))))))).<.(.(........).).((((((....(((.((((((((((..(((...(((....)))...)))...((....))...((......)).........)))))))))))))..((.(...((((((.....((((((((((.((((....((((()))))....)<)))...(((..(.((........)).).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((..(((((.((((((...(((...(((.((((......)))).)))..)).)...)))))).).))).)))))))).))..(((((((.((......)).)))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((.((((..........((.(.(...((.........).)...).)........((......))...))......)))).))))).))..........]]].)....))))))))))...)))))))(..(((((...)))))..)....))))))(.(((((((.((......(((((.((....))])))))...)).)))))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((((((...((...((((....(((((.(((..(((((.((((.((...{{....))))))(((((((.((..((((((((((...((.....)).)))))).))))..)))))))))...(.)....)))))...)))..)))))(..).....))))...))......))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.[..).....)))))((((((((.))))))))(...).......(((((((((.>.(...........)...(((((((.....(((.....))).......))))))).]((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(..)(..)...((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).[..(((((.....>].)))))..((((((((.(((..(......((((.((((((..((((..(((.(((((.(..(....(..(.......).).....).)...((((((.......)).))))....))))).)))...))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....((((.((....))..))))....)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))....((....((((.............))))....))..))))..]....)))))))(.((..))....(((((((((.......)))))....((((((((.((.....(((((....)))))....))..))))).)))...))))...)))))))).. 50S Deinococcus radiodurans ribosome bounded with mycinamicin IV; RNA (2699-MER) 7a18 Y 122 3.4 RF00001 URS000080E31C_243230 34417608 0003735 0005840 243230 cacccccgugcccauagcacuguggaaccaccccaccccaugccgaacugggucgugaaacacagcagcgccaaugauacucggaccgcagggucccggaaaagucggucagcgcggggguu .<<<<<<<<<<.....<<.<<<<<....<<<<<<<.............>>>>..>>>...>>>>>..>><<<.......<<.<<<<<....>>>>>.>>.......>>>..>>>>>>>>>>. .((((((((((.....((.(.(((....(((..(....(.....)....)....)))...))).)..))(((.......(..(((((....)))))..).......)))..)))))))))). 50S Deinococcus radiodurans ribosome bounded with mycinamicin IV; RNA (122-MER) 7a3y A 13 NA URS00021ED8F9_32630 32630 gcagcucguccug ............. ............. RNA duplex with a cytosine bulge in complex with berberine; RNA-A chain A 7a3y B 12 NA URS00021ED8FF_32630 32630 caggauagcugc ............ ............ RNA duplex with a cytosine bulge in complex with berberine; RNA-A chain B 7a5f A3 1503 4.4 RF02541,RF02540 URS000080E357_9606 33243891 0003735 0005840 9606 gcuaaaccuagccccaaacccacuccaccuuacuaccagcaaccuuagccaaaccauuuacauaaaguauaggcgauagaaauuguggcgcaauagauauaguaccgcaagggaaagaugaaaaauuauaaccaagcauaauauagcaaggacuaaccccuauaccuucugcauaaugaauuaacuagaaauaacuuugcaaggagagccaaagcuaagacccccgaaaccagacgagcuaccuaagaacagcuaagagcacacccgucuauguagcaaaauagugggaagauuuauagguagaggcgacaaaccuaccgagccuggugauagcugguuguccaagauagaaucuuaguucaacuuuaaauuugcccacagaaccaaauccccuuguaaauuuaacuguuaguccaaagaggaacagcucuuuggacacuaggaaaaaaccuuguagagagaguaaaaaauuuaacacccauaguaggccuaaaagcagccaccaauuaagaaagcguucaagcucaacaccaaaaaucccaaacauauaacugaacuccucacacccaauuggaccaaucuaucacccuauagaagaacuaauguuaguauaaguaacaugaaaacauucuccuccgcauaagccugcgucagaucacacugacaauuaacagcccaauaucuacaaucaaccaacaagucauuauuacccucacugucaacccaacacaggcaugcucauaaggaaagguuaaaaaaaguaaaaggaacucggcaaaucuuaccccgccuguuuaccaaaaacaucaccucuagcaucaccaguauuagaggcaccgccugcccagugacacauguuuaacggccgcgguuaaccgugcaaagguagcauaaucacuuguuccuuaaauagggaccuguaugaauggcuccacgaggguucagcugucucuuacuuuuaaccagugaaauugaccugcccgugaagaggcgggcauaacacagcaagacgagaagacccuauggagcuuuaauuuauuaaugcaaacaguaccuaacaaacccacagguccuaaacuaccaaaccugcauuaaaaauuucgguuggggcgaccucggagcagaacccaaccuccgagcaguacaugcuaagacuucaccagucaaagcgaaccucaauugauccaauaacuugaccaacggaacaaguuacccuagggauaacagcgcaauccuauucuagaguccauaucaacaauaggguuuacgaccucgauguuggaucaggacaucccgauggugcagccgcuauuaaagguucguuuguucaacgauuaaaguccuacgugaucugaguucagaccggaguaauccaggucgguuucuaucuacuuuauuccucccuguacgaaaggacaagagaaauaaggccuacuucacaaagcgccuucccccguaaaugauaucaucucaacuuagauacccacacccaagaacaggguu <<<.......<<<<....................................<......>...........<<.....>>........>>.>>.............<<....>>......................>>>...........<<<.......>>>...<.<........>.>.<<<<<<.........<<<.<<..<<....>>...>>.>>>...<<.<...<<<<.<.....<<<<<.<<<..<<<...>>>...<<<..<<<<........>>>>.>>>....>>>.>>>>>...<<.......>>......>.>>>>......>.>>..<<<<<<....<<<<....>>>><<<.<<<<<<<<<<.....<<......>>.....>>>>>>>>>>..>>>.<<<<<<<<<<......>>>>>>>>>>...<<<......>>>....<<<.<<<...<..............<....<<<.........>>>....>.......<<<......>>>...........................>...>>>>>>........>>>>>>...<<<<<......>>>>>.........>>>>>><......<<..<<<....>>><<<<..<<<<........<<<<<......>>>>>......<<<...<<<<.......................>>>>.......>>>.....<<......>>.>>>>.....>>>>..<<<<...<<<<<<<<.<<................<<<<<<..<<<.........>>>...<<<<<<.............>>>>>>....<<<.<<<..<<<<<....>>>..>>>>><<<<<....>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>....>>.>>>>........>>.>>>>>>>>>>>>.>>.....>.....<<<<<........>>>>>.......<<..<<<.<<......<<<<.<<<<<<..<<<<<..<<<<<<<.........................................>>>>>>>.>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<.....<<<..<<<<.....>>>>..>>>....>>.........<<<....>>>............>>>>..>>>>>>.......<<<..<.<<<<<<...<<.......>>...>>>>>>...>.>>.>.......<<<<<.<<<<<<..<<.<<<<<<......>>>>>>...>>.<<<<.......>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>..<<<.<<<.................>>>.>>><<<<<...<<<....>>>.>>>>>......<<<................>>>.........<<<<.......>>>>. ((.....(..((((........................................[........(.....((.]...))....)...)).)).............((....))....).....(...)........)).........(.(((.......))).[.(.(........).).(.((((.........(((.((..((....))...)).)))...((.(...((((.(.....(((((.((((.(((..[)))...(((..((((.......{)))).)))..).))).))))).(.((.......))...)..).))))......).))..((((((....((((....)))).((.((((((((((.....((......)).....))))))))))..))..((((((((((......))))))))))...(((......)))....(((.(((...(..............(.(..(((.........)))..).)....(..(..........))..........................)...))))))........))))))...(((((......))))).........)))).)(......((..(((....)))(((...((((......(.(((((......)))))......(((...((((...............(..)....)))).......))).)...((......)).))))......)))..((((....(((((((.((..(....(........((((((.].((.........))....((((((.............))))))....(((.(((..(((((....)))..)))))((.((....)).))........((..........(((((.......)))))..)..)....)))....)).))))....)..))).))))))).)))).)).....)).{..(((((.....]}.))))).......((..(((.((......((((.((((((..(((((.((((((((................(......).................)))))))))))))..(((......[)))((((((..........]))))))(.((.....((...(((....[..)))...))....)).........(((....))).....)].....))))..))))))......((((..(.((((((.(.((.......)))..))))))...).)).).).....(((((.((((((..((.((((((......))))))...)).(((((.....))))).....)))))..)...))).))....(((((((....))).))))..}.))..))).))..(((.(((.................))).)))(((((...(((....))).)))))......(((................))).........((((.......)))). Structure of the stalled human mitoribosome with P- and E-site mt-tRNAs; 16S rRNA 7a5f A6 928 4.4 RF00177 URS00021ED90F_9606 33243891 0003735 0005840 9606 auagguuugguccuagccuuucuauuagcucuuaguaagauuacacaugcaagcauccccguuccagugaguucacccucuaaaucgaucaaaaggaacaagcaucaagcacgcagcaaugcagcucaaaacgcuuagccuagccacacccccacgggaaacagcagugauuaaccuuuagcaauaaacgaaaguuuaacuaagcuauacuaaccccaggguuggucaauuucgugccagccaccgcggucacacgauuaacccaagucaauagaaccggcguaaagaguguuuuagaucacaauaaagcuaaaacucaccugaguuguaaaaaacuccaguugacacaaaauagacuacgaaaguggcuuuaacauaucugaacacacaauagcuaagacccaaacugggauuagauaccccacuaugcuuagcccuaaaccucaacaguucaacaaaacugcucgccagaacacuacgagccacagcuuaaaacucaaaggaccuggcggugcuucauaucccucuagaggagccuguucuguaaucgauaaaccccgaucaaccucaccaccucuugcucagccuauauaccgccaucuucagcaaacccugaugaaggcuacaaaguaagcgcaaguacccacguaaagacguuaggucaagguguagcccaugagguggcaagaaaugggcuacauuuucuaccccagaaacgauagcccuuaugaaauaagggucgaagguggauuuagcaguaaacuaagaguagagugcuuaguugaacagggcccugaagcgcguacacaccgcccgucacccuccucaaguauacuucaaaggacaauuaacuaaaaccccuacgcauuuauauagaggagacaagucguaacaugguaaguguacuggaaagugcacuuggacgaac ..((((..<<<<<<.)))).<<<<<<.<<..<<<<<<<<..<.<<<.<<<..<......>......<<........<<<.<..<<..>>.>..>>>...<<<<....<<...<<<....>>>..>>......>>>>.<<...>>.>>.<<<....>>>.....>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>.....<<<<<<<<.....(((.....((.>>>)).......)))..>>>>>..>>.>>>>>>...<<<((.....<<<<..<<<<......<<<<<<......<<<.<<<.<<<......>>>..>>>.>>>.............<<....>>.>>>>>>.....>>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<.<<<<<..))..>>>>>.>.>>>.<<.......<<<<....>>>>.....>>..>>>>>><<<<<.<<<<<<<...<<<.<<<<<..<<<<<<<<<<.....<<........>>..........<<<<<<<.......<<.<<<..<<<<<<.......<<..<<<<<.....>>>.......>>..>>.....<<<....>>>.........>>>...>>>>>>>>....>>>>>>>..>>.>>>>>>>>.....<<<<.....>>>>.<....<<<<<<<<...>>>>>>>>....>.....>>>>>.....<<<<<<<.........>>>>>>>.....>>>...>>>>>>>>>>.>>....<..<<.<...<<<<<<..<<<<<......<<<....<<.....>>...>>>.......>>>>>.>>>>>>....>.>>...>.....<<<<<<<<<....>>>>>>>>>........ [.[[[[..(((((..]]]]]((((((.((..((((((((..(.(((.(((..(......)......(((.......(((.(..((())).)..)))...((((....((..((((....))).)))......)))).((...))))).(((....))).....)))))))......(.(((...(((((....)))).))))).)).)))))).....((((([[[.....(((.....((.]]])).......)))..)))))..)).))))))...((([[...(.((((...(((......(((((((.....(((.(((.((........))..))).))).....).....(.((....))))))))).....)))....))))....((((((...((...((((.........))))...))))))))......{...(.(((((..]]..))))).))))).((.......((((....)))).....))...)))))(((((.(((((((...(((.(((((..((((((((((.....((........))..........((((((........((.(((...((((((.(....((..(((((.....))).......))..)).....(((....))).....).).)))...)).))))).....))))))..)).)))))))).(...((((.....)))).(....(((((((.....)))))))....)..)..))))).....(((((((.........))))))).....)))...)))))))))).))..(.(..((.(...((((((...((((..((..(((....((.....))...)))..).)..))))..))))))....).))...)..)..(((((((((....)))))))))}....... Structure of the stalled human mitoribosome with P- and E-site mt-tRNAs; 12S rRNA 7a5f 24 73 4.4 RF00005 URS00021ED9B1_9606 33243891 0030533 0006412 9606 guuaauguagcuuaaauuaucaaagcaaggcacugaaaaugccuagaugagccucacagcuccauuaacacca <<<<<<<.................<................>....................>>>>>>>.... (((((((.........................................(..........)..))))))).... Structure of the stalled human mitoribosome with P- and E-site mt-tRNAs; mt-tRNA 7a5f i4 10 4.4 33243891 9606 aaaaguaaaa .......... .......... Structure of the stalled human mitoribosome with P- and E-site mt-tRNAs; mRNA 7a5f C 73 4.4 RF00005 URS00021ED9B1_9606 33243891 0030533 0006412 9606 guuaauguagcuuaaauuaucaaagcaaggcacugaaaaugccuagaugagccucacagcuccauuaacacca <<<<<<<.................<................>....................>>>>>>>.... (((((((.........................................(..........)..))))))).... Structure of the stalled human mitoribosome with P- and E-site mt-tRNAs; mt-tRNA 7a5g A3 1503 4.33 RF02541,RF02540 URS000080E357_9606 33243891 0003735 0005840 9606 gcuaaaccuagccccaaacccacuccaccuuacuaccagcaaccuuagccaaaccauuuacauaaaguauaggcgauagaaauuguggcgcaauagauauaguaccgcaagggaaagaugaaaaauuauaaccaagcauaauauagcaaggacuaaccccuauaccuucugcauaaugaauuaacuagaaauaacuuugcaaggagagccaaagcuaagacccccgaaaccagacgagcuaccuaagaacagcuaagagcacacccgucuauguagcaaaauagugggaagauuuauagguagaggcgacaaaccuaccgagccuggugauagcugguuguccaagauagaaucuuaguucaacuuuaaauuugcccacagaaccaaauccccuuguaaauuuaacuguuaguccaaagaggaacagcucuuuggacacuaggaaaaaaccuuguagagagaguaaaaaauuuaacacccauaguaggccuaaaagcagccaccaauuaagaaagcguucaagcucaacaccaaaaaucccaaacauauaacugaacuccucacacccaauuggaccaaucuaucacccuauagaagaacuaauguuaguauaaguaacaugaaaacauucuccuccgcauaagccugcgucagaucacacugacaauuaacagcccaauaucuacaaucaaccaacaagucauuauuacccucacugucaacccaacacaggcaugcucauaaggaaagguuaaaaaaaguaaaaggaacucggcaaaucuuaccccgccuguuuaccaaaaacaucaccucuagcaucaccaguauuagaggcaccgccugcccagugacacauguuuaacggccgcgguuaaccgugcaaagguagcauaaucacuuguuccuuaaauagggaccuguaugaauggcuccacgaggguucagcugucucuuacuuuuaaccagugaaauugaccugcccgugaagaggcgggcauaacacagcaagacgagaagacccuauggagcuuuaauuuauuaaugcaaacaguaccuaacaaacccacagguccuaaacuaccaaaccugcauuaaaaauuucgguuggggcgaccucggagcagaacccaaccuccgagcaguacaugcuaagacuucaccagucaaagcgaaccucaauugauccaauaacuugaccaacggaacaaguuacccuagggauaacagcgcaauccuauucuagaguccauaucaacaauaggguuuacgaccucgauguuggaucaggacaucccgauggugcagccgcuauuaaagguucguuuguucaacgauuaaaguccuacgugaucugaguucagaccggaguaauccaggucgguuucuaucuacuuuauuccucccuguacgaaaggacaagagaaauaaggccuacuucacaaagcgccuucccccguaaaugauaucaucucaacuuagauacccacacccaagaacaggguu <<<.......<<<<....................................<......>...........<<.....>>........>>.>>.............<<....>>......................>>>...........<<<.......>>>...<.<........>.>.<<<<<<.........<<<.<<..<<....>>...>>.>>>...<<.<..<<<<<.<.....<<<<<.<<<..<<<...>>>...<<<<.<<<<........>>>>>>>>....>>>.>>>>>...<<.......>>......>.>>>>...>..>.>>..<<<<<<....<<<<....>>>><<<.<<<<<<<<<<.....<<......>>.....>>>>>>>>>>..>>>.<<<<<<<<<<......>>>>>>>>>>...<<<......>>>....<<<.<<<...<..............<....<<<.........>>>....>.......<<<......>>>...........................>...>>>>>>........>>>>>>...<<<<<......>>>>>.........>>>>>><......<<..<<<....>>><<<<..<<<<........<<<<<......>>>>>......<<<...<<<<.......................>>>>.......>>>.....<<......>>.>>>>.....>>>>..<<<<...<<<<<<<<.<<.........<......<<<<<<..<<<.........>>>...<<<<<<.............>>>>>>....<<<.<<<..<<<<<....>>>..>>>>><<<<<....>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>....>>.>>>>.....>..>>.>>>>>>>>>>>>.>>.....>.....<<<<<........>>>>>.......<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<.........................................>>>>>>>>>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<.....<<<..<<<<.....>>>>..>>>....>>.........<<<....>>>............>>>>..>>>>>>.......<<<..<.<<<<<<...<<.......>>...>>>>>>...>.>>.>.......<<<<<.<<<<<<..<<.<<<<<<......>>>>>>...>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>..<<<.<<<.................>>>.>>><<<<<...<<<....>>>.>>>>>......<<<................>>>.........<<<<.......>>>>. ((.....(..((((....................................(...[..).....(.....((.]...))....)...)).)).............((....))....).....(...)........)).........(.(((.......))).{.(.(........).).((((((.........(((.((..((....))...)).)))...((.(...((((.(.....(((((.((((.(((..[)))...(((..((((........)))).)))..).))).))))).(.((.......))...)..).))))......).))..((((((..(.((((....)))).((.((((((((((.....(........).....))))))))))..))..((((((((((......)))))))))))..(((......)))....(((.(((...(..............(.(..(((.........)))..).)....(..(((......))))..........................)...))))))........))))))...(((((......))))).........))))))(......((..(((....)))(((...((((......(.(((((......)))))......(((...((((...............(..)....)))).......))).)...((......)).))))......)))..((((....(((((((.((..(....(........(.((((.].((.........))....((((((.............))))))....(((.(((..(((((....)))..)))))(((((....)))))........((..........(((((.......)))))..)..)....)))....)).)).)....)..))).))))))).)))).)).....)).[..(((((.....}].))))).......((..(((.((......((((.((((((..(((((.((((((((................(......).................)))))))))))))..(((......[)))((((((..........]))))))(.((.....((...(((....[..)))...))....)).........(((....))).....)].....))))..))))))......((((..(.((((((.(.((.......)))..))))))...).)).).).....(((((.((((((..((.((((((......))))))...)).(((((.....))))).....)))))..)...))).))....(((((((....))).))))....))..))).))..(((.(((......(....).....))).)))(((((...(((....))).)))))......(((................))).........((((.......)))). Structure of the elongating human mitoribosome bound to mtEF-Tu.GMPPCP and A/T mt-tRNA; 16S rRNA 7a5g A6 928 4.33 RF00177 URS00021ED90F_9606 33243891 0003735 0005840 9606 auagguuugguccuagccuuucuauuagcucuuaguaagauuacacaugcaagcauccccguuccagugaguucacccucuaaaucgaucaaaaggaacaagcaucaagcacgcagcaaugcagcucaaaacgcuuagccuagccacacccccacgggaaacagcagugauuaaccuuuagcaauaaacgaaaguuuaacuaagcuauacuaaccccaggguuggucaauuucgugccagccaccgcggucacacgauuaacccaagucaauagaaccggcguaaagaguguuuuagaucacaauaaagcuaaaacucaccugaguuguaaaaaacuccaguugacacaaaauagacuacgaaaguggcuuuaacauaucugaacacacaauagcuaagacccaaacugggauuagauaccccacuaugcuuagcccuaaaccucaacaguucaacaaaacugcucgccagaacacuacgagccacagcuuaaaacucaaaggaccuggcggugcuucauaucccucuagaggagccuguucuguaaucgauaaaccccgaucaaccucaccaccucuugcucagccuauauaccgccaucuucagcaaacccugaugaaggcuacaaaguaagcgcaaguacccacguaaagacguuaggucaagguguagcccaugagguggcaagaaaugggcuacauuuucuaccccagaaacgauagcccuuaugaaauaagggucgaagguggauuuagcaguaaacuaagaguagagugcuuaguugaacagggcccugaagcgcguacacaccgcccgucacccuccucaaguauacuucaaaggacaauuaacuaaaaccccuacgcauuuauauagaggagacaagucguaacaugguaaguguacuggaaagugcacuuggacgaac ..((((..<<<<<<.)))).<<<<<<.<<..<<<<<<<<....<<<.<<<..<......>......<<........<<<....<<..>>....>>>...<<<<....<<...<<<....>>>..>>......>>>>.<<...>>.>>.<<<....>>>.....>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>.....<<<<<<<<.....(((.....((.>>>)).......)))..>>>>>..>>.>>>>>>...<<<((.....<<<<..<<<<......<<<<<<......<<<.<<<.<<<......>>>..>>>.>>>.............<<....>>.>>>>>>.....>>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<.<<<<<..))..>>>>>.>.>>>.<<.......<<<<....>>>>.....>>..>>>>>><<<<<.<<<<<<<...<<<.<<<<<..<<<<<<<<<<.....<<........>>..........<<<<<<<.......<<.<<<..<<<<<<.......<<..<<<<<.....>>>.......>>..>>.....<<<....>>>.........>>>...>>>>>>>>....>>>>>>>..>>.>>>>>>>>.....<<<<.....>>>>.<....<<<<<<<<...>>>>>>>>....>.....>>>>>.....<<<<<<<.........>>>>>>>.....>>>...>>>>>>>>>>.>>....<..<<.<...<<<<<<..<<<<<......<<<....<<.....>>...>>>.......>>>>>.>>>>>>....>.>>...>.....<<<<<<<<<....>>>>>>>>>........ [.[[[[..(((((..]]]]]((((((.((..((((((((..(.(((.(((..(......)......(((.......(((.(..((())).)..)))...((((....((..((((....))).)))......)))).((...))))).(((....))).....)))))))......(.(((...(((((....)))).))))).)).)))))).....((((([[[.....(((.....((.]]])).......)))..)))))..)).))))))...((([[...(.((((...(((......(((((((.....(((.(((.((........))..))).))).....).....(.((....))))))))).....)))....))))....((((((...((...((((.........))))...))))))))......{...(.(((((..]]..))))).))))).((.......((((....)))).....))...)))))(((((.(((((((...(((.(((((..((((((((((.....((........))..........(((((((.......((.(((...((((((.(....((..(((((.....))).......))..)).....(((....))).....).).)))...)).)))))....)))))))..)).)))))))).(...((((.....)))).(....(((((((.....)))))))....)..)..))))).....(((((((.........))))))).....)))...)))))))))).))..(.(..((.(...((((((..(((((..((..(((....((.....))...)))..).)..))))).))))))....).))...)..)..(((((((((....)))))))))}....... Structure of the elongating human mitoribosome bound to mtEF-Tu.GMPPCP and A/T mt-tRNA; 12S rRNA 7a5g 24 73 4.33 RF00005 URS00021ED9B1_9606 33243891 0030533 0006412 9606 guuaauguagcuuaaauuaucaaagcaaggcacugaaaaugccuagaugagccucacagcuccauuaacacca <<<<<<<.................<................>....................>>>>>>>.... (((((((.........................................(..........)..))))))).... Structure of the elongating human mitoribosome bound to mtEF-Tu.GMPPCP and A/T mt-tRNA; P tRNA 7a5g i4 10 4.33 33243891 9606 aaaaguguua .......... .......... Structure of the elongating human mitoribosome bound to mtEF-Tu.GMPPCP and A/T mt-tRNA; mRNA 7a5g j 76 4.33 RF00005 URS0000868530_9606 33243891 0030533 9606 gucuccguaguguagcgguuaucacguucgccuaacacgcgaaagguccucgguucgaaaccgggcggaaacacca <<.<<<<....<<.......>>....<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>.>>.... ((.((((..(.((.......))..).(((((.......))))).....(.(((.......))).))))).)).... Structure of the elongating human mitoribosome bound to mtEF-Tu.GMPPCP and A/T mt-tRNA; E tRNA 7a5g C 73 4.33 RF00005 URS00021ED9B1_9606 33243891 0030533 0006412 9606 guuaauguagcuuaaauuaucaaagcaaggcacugaaaaugccuagaugagccucacagcuccauuaacacca <<<<<<<.................<................>....................>>>>>>>.... (((((((.........................................(..........)..))))))).... Structure of the elongating human mitoribosome bound to mtEF-Tu.GMPPCP and A/T mt-tRNA; P tRNA 7a5h A 1457 3.3 RF02541,RF02540 URS000080E357_9606 33243891 0003735 0005840 9606 gcuaaaccuagccccaaacccccaccuuacuaccaaaccuuagccaaaccauuuacauaaaguauaggcgauagaaauugggcgcaauagauauaguaccgcaagggaaagaugaaaaaaccaagcauaauauagcaaggacuaaccccuauaccuucugcauaaugaauuaacuagaaauaacuuugcaaggagagccaaagcuaagacccccgaaaccagacgagcuaccuaagaacagcuaagagcacacccgucuauguagcaaaauagugggaagauuuauagguagaggcgacaaaccuaccgagccuggugauagcugguuguccaagauagaaucuuaguucaacuuuaaauuugcccacagaaccaaauccccuuguaaauuuaacuguuaguccaaagaggaacagcucuuuggacacuaggaaaaaaccuuguagagagaguaaaaaauuuaacacccauaguaggccuaaaagcagccaccaauuaagaaagcguucaagcucaacacaaaaaucccaaacauauaacugaacuccucacacccaauuggaccaaucuaucacccuauagaagaacuaauguuaguauaaguaacaugaaaacauucuccuccgcauaagccugcgucagcaacugacaauuaacagcccaauaucuacaaucaaccaacaagucauuauuacccucacugucaacccaacacaggcaugcucauaaggaaagguuaaaaaaaguaaaaggaacucggcaaaucuuaccccgccuguuuaccaaaaacaucaccucuagcaucaccaguauuagaggcaccgccugcccagugacacauguuuaacggccgcgguacccuaaccgugcaaagguagcauaaucacuuguuccuuaaauagggaccuguaugaauggcuccacgaggguucagcugucucuuacuuuuaaccagugaaauugaccugcccgugaagaggcgggcauaacacagcaagacgagaagacccuauggagcuuuaauuuauuaaugcaaacaccugcauuaaaaauuucgguuggggcgaccucggagcagaacccaaccuccgagcaguacaugcuaagacuucaccagucaaagcgaaccucaauugauccaauaacuugaccaacggaacaaguuacccuagggauaacagcgcaauccuauucuagaguccauaucaacaauaggguuuacgaccucgauguuggaucaggacaucccgauggugcagccgcuauuaaagguucguuuguucaacgauuaaaguccuacgugaucugaguucagaccggaguaauccaggucgguuucuaucuacuuuauuccucccuguacgaaaggacaagagaaauaaggccuacuucacaaagcgccuucccccguaaaugauaucaucucaacuuagauacccacacccaagaacaggguu <<<.......<<<<...............................<......>...........<<.....>>.......>>.>>.............<<....>>.................>>>...........<<<.......>>>...<.<........>.>.<<<<<<.........<<<.<<..<<....>>...>>.>>>...<<.<...<<<<.<.....<<<<<.<<<..<<<...>>>...<<<..<<<<........>>>>.>>>....>>>.>>>>>...<<.......>>......>.>>>>......>.>>..<<<<<<....<<<<....>>>><<<.<<<<<<<<<<.....<<......>>.....>>>>>>>>>>..>>>.<<<<<<<<<<......>>>>>>>>>>...<<<......>>>....<<<.<<<...<...................<<<.........>>>............<<<......>>>..........................>...>>>>>>........>>>>>>...<<<<<......>>>>>.........>>>>>><......<<..<<<....>>><<<<..<<<<........<<<<<...>>>>>......<<<...<<<<.......................>>>>.......>>>.....<<......>>.>>>>.....>>>>..<<<<...<<<<<<<<.<<.........<......<<<<<<..<<<.........>>>...<<<<<<.............>>>>>>....<<<.<<<..<<<<<....>>>..>>>>><<<<..........>>>>........<...........<<<<<<.....>>>>>>.....>....>>>....>>.>>>>.....>..>>.>>>>>>>>>>>>.>>.....>.....<<<<<........>>>>>.......<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<......>>>>>>>>>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<.....<<<..<<<<.....>>>>..>>>....>>.........<<<....>>>............>>>>..>>>>>>.......<<<..<.<<<<<<...<<.......>>...>>>>>>...>.>>.>.......<<<<<..<<<<<..<<.<<<<<<......>>>>>>...>>.<<<<<.....>>>>>.....>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>..<<<.<<<.................>>>.>>><<<<<...<<<....>>>.>>>>>......<<<................>>>.........<<<<.......>>>>. ((.....(..((((...............................(...[..).....(.....((.]...))....)..)).)).............((....))....).............)).........(.(((.......))).[.(.(........).).((((((.........(((.((..((....))...)).)))...((.(...((((.(.....(((((.((((.(((..[)))...(((..((((.......{)))).)))..).))).))))).(.((.......))...)..).))))......).))..((((((....((((....)))).((.((((((((((.....((......)).....))))))))))..))..((((((((((......))))))))))...(((......)))....(((.(((...(..............(.(..(((.........)))..).)....(..(((......)))).........................)...))))))........))))))...(((((......))))).........))))))(......((..(((....)))(((...((((......(.(((((...)))))......(((...((((...............(..)....)))).......))).)...((......)).))))......)))..((((....(((((((.((..(....(........((((((.].((.........))....((((((.............))))))....(((.(((..(((((....)))..)))))((((..........))))........((..........(((((.......)))))..)..)....)))....)).))))....)..))).))))))).)))).)).....)).{..(((((.....]}.))))).......((..(((.((......((((.((((((..(((((.((((((((......)))))))))))))..(((......[)))((((((..........]))))))(.((.....((...(((....[..)))...))....)).........(((....))).....)].....))))..))))))......((((..(.((((((.(.((.......)))..))))))...).)).).).....(((((.((((((..((.((((((......))))))...)).(((((.....))))).....)))))..)...))).))....(((((((....))).))))..}.))..))).))..(((.(((......(....).....))).)))(((((...(((....))).)))))......(((................))).........((((.......)))). Structure of the split human mitoribosomal large subunit with rescue factors mtRF-R and MTRES1; 16S rRNA 7a5h 24 73 3.3 RF00005 URS00021ED9B1_9606 33243891 0030533 0006412 9606 guuaauguagcuuaaauuaucaaagcaaggcacugaaaaugccuagaugagccucacagcuccauuaacacca <<<<<<<.........................................<..........>..>>>>>>>.... (((((((.......................................................))))))).... Structure of the split human mitoribosomal large subunit with rescue factors mtRF-R and MTRES1; mt-tRNA 7a5i A3 1485 3.7 RF02541,RF02540 URS000080E357_9606 33243891 0003735 0005840 9606 gcuaaaccuagccccaaacccacuccaccuuacuaccagcaaccuuagccaaaccauuuacauaaaguauaggcgauagaaauuguggcgcaauagauauaguaccgcaagggaaagaugaaaaauuauaaccaagcauaauauagcaaggacuaaccccuauaccuucugcauaaugaauuaacuagaaauaacuuugcaaggagagccaaagcuaagacccccgaaaccagacgagcuaccuaagaacagcuaagagcacacccgucuauguagcaaaauagugggaagauuuauagguagaggcgacaaaccuaccgagccuggugauagcugguuguccaagauagaaucuuaguucaacuuuaaauuugcccacagaaccaaauccccuuguaaauuuaacuguuaguccaaagaggaacagcucuuuggacacuaggaaaaaaccuuguagagagaguaaaaaauuuaacacccauaguaggccuaaaagcagccaccaauuaagaaagcguucaagcucaacacccacuaccuaaaaaaucccaaacauauaacugaacuccucacacccaauuggaccaaucuaucacccuauagaagaacuaauguuaguauaaguaacaugaaaacauucuccuccgcauaagccugcgucagaucacacugacaauuaacagcccaauaucuacaaucaaccaacaagucauuauuacccucacugucaacccaacacaggcaugcucauaaggaaagguuaaaaaaaguaaaaggaacucggcaaaucuuaccccgccuguuuaccaaaaacaucaccucuagcaucaccaguauuagaggcaccgccugcccagugacacauguuuaacggccgcgguacccuaaccgugcaaagguagcauaaucacuuguuccuuaaauagggaccuguaugaauggcuccacgaggguucagcugucucuuacuuuuaaccagugaaauugaccugcccgugaagaggcgggcauaacacagcaagacgagaagacccuauggagcuuuaauuuauuaaugcaaacaguaaccugcauuaaaaauuucgguuggggcgaccucggagcagaacccaaccuccgagcaguacaugcuaagacuucaccagucaaagcgaaccucaauugauccaauaacuugaccaacggaacaaguuacccuagggauaacagcgcaauccuauucuagaguccauaucaacaauaggguuuacgaccucgauguuggaucaggacaucccgauggugcagccgcuauuaaagguucguuuguucaacgauuaaaguccuacgugaucugaguucagaccggaguaauccaggucgguuucuaucuacuuuauuccucccuguacgaaaggacaagagaaauaaggccuacuucacaaagcgccuucccccguaaaugauaucaucucaacuuagauacccacacccaagaacaggguu <<<.......<<<<....................................<......>.....<.....<<.....>>....>...>>.>>.............<<....>>......................>>>...........<<<.......>>>...<.<........>.>.<<<<<<.........<<<.<<..<<....>>...>>.>>>...<<.<..<<<<<.<.....<<<<<.<<<..<<<...>>>...<<<..<<<<........>>>>.>>>....>>>.>>>>>...<<.......>>......>.>>>>...>..>.>>..<<<<<<....<<<<....>>>><<<.<<<<<<<<<<.....<<......>>.....>>>>>>>>>>..>>>.<<<<<<<<<<......>>>>>>>>>>...<<<......>>>....<<<.<<<...<..............<....<<<.........>>>....>.......<<<......>>>....................................>...>>>>>>........>>>>>>...<<<<<......>>>>>.........>>>>>>.......<<..<<<....>>><<<<..<<<<........<<<<<......>>>>>......<<<...<<<<.......................>>>>.......>>>.....<<......>>.>>>>.....>>>>..<<<<...<<<<<<<<.<<................<<<<<<..<<<.........>>>...<<<<<<.............>>>>>>....<<<.<<<..<<<<<....>>>..>>>>><<<<<<......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>....>>.>>>>........>>.>>>>>>>>>>>>.>>...........<<<<<........>>>>>.......<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<..........>>>>>>>>>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<.....<<<..<<<<.....>>>>..>>>....>>.........<<<....>>>............>>>>..>>>>>>.......<<<..<.<<<<<<...<<.......>>...>>>>>>...>.>>.>.......<<<<<.<<<<<<..<<.<<<<<<......>>>>>>...>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>..<<<.<<<.................>>>.>>><<<<<...<<<....>>>.>>>>>......<<<................>>>.........<<<<.......>>>>. ((.....(..((((....................................(...[..).....(.....((.]...))....)...)).)).............((....))....).....(...)........)).........(.(((.......))).[.(.(........).).((((((..(......(((..(..((....))...)..)))...((.(...((((.(.....(((((.((((.(((..[)))...(((..((((.......{)))).)))..).))).))))).(.((.......))...)..).))))......).))).((((((....((((....)))).((.((((((((((.....((......)).....))))))))))..))..((((((((((......))))))))))...(((......)))....(((.(((...(................(..(((.........)))..)......(..(((......))))...................................)...))))))........))))))...(((((......))))).........))))))(......((..(((....)))(((...((((......(.(((((......)))))......(((...((((...............(..)....)))).......))).)...((......)).))))......)))..((((....(((((((.((..(....(........((((((.].((.........))....((((((.............))))))....(((.(((..(((((....)))..)))))((((((......))))))........((..........(((((.......)))))..)..)....)))....)).))))....)..))).))))))).)))).)).....)).{..(((((.....]}.))))).......((..(((.((......((((.((((((..(((((.((((((((..........)))))))))))))..(((......[)))((((((..........]))))))(.((.....((...(((....[..)))...))....)).........(((....))).....)].....))))..))))))......((((..(.((((((.(.((.......)))..))))))...).)).).)......((((.((((((..((.((((((......))))))...)).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..}.))..))).))..(((.(((......(....).....))).)))(((((...(((....))).)))))......(((................))).........((((.......)))). Structure of the human mitoribosome with A- P-and E-site mt-tRNAs; 16S rRNA 7a5i A6 928 3.7 RF00177 URS00021ED90F_9606 33243891 0003735 0005840 9606 auagguuugguccuagccuuucuauuagcucuuaguaagauuacacaugcaagcauccccguuccagugaguucacccucuaaaucgaucaaaaggaacaagcaucaagcacgcagcaaugcagcucaaaacgcuuagccuagccacacccccacgggaaacagcagugauuaaccuuuagcaauaaacgaaaguuuaacuaagcuauacuaaccccaggguuggucaauuucgugccagccaccgcggucacacgauuaacccaagucaauagaaccggcguaaagaguguuuuagaucacaauaaagcuaaaacucaccugaguuguaaaaaacuccaguugacacaaaauagacuacgaaaguggcuuuaacauaucugaacacacaauagcuaagacccaaacugggauuagauaccccacuaugcuuagcccuaaaccucaacaguucaacaaaacugcucgccagaacacuacgagccacagcuuaaaacucaaaggaccuggcggugcuucauaucccucuagaggagccuguucuguaaucgauaaaccccgaucaaccucaccaccucuugcucagccuauauaccgccaucuucagcaaacccugaugaaggcuacaaaguaagcgcaaguacccacguaaagacguuaggucaagguguagcccaugagguggcaagaaaugggcuacauuuucuaccccagaaacgauagcccuuaugaaauaagggucgaagguggauuuagcaguaaacuaagaguagagugcuuaguugaacagggcccugaagcgcguacacaccgcccgucacccuccucaaguauacuucaaaggacaauuaacuaaaaccccuacgcauuuauauagaggagacaagucguaacaugguaaguguacuggaaagugcacuuggacgaac ..((((..<<<<<<.)))).<<<<<<.<<..<<<<<<<<..<.<<<.<<<..<......>......<<........<<<....<<..>>....>>>...<<<<....<<...<<<....>>>..>>......>>>>.<<...>>.>>.<<<....>>>.....>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>.....<<<<<<<<.....(((.....((.>>>)).......)))..>>>>>..>>.>>>>>>...<<<((.....<<<<..<<<<......<<<<<<......<<<.<<<.<<<......>>>..>>>.>>>.............<<....>>.>>>>>>.....>>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<.<<<<<..))..>>>>>.>.>>>.<<.......<<<<....>>>>.....>>..>>>>>><<<<<.<<<<<<<...<<<.<<<<<..<<<<<<<<<<.....<<........>>..........<<<<<<<.......<<.<<<..<<<<<<.......<<..<<<<<.....>>>.......>>..>>.....<<<....>>>.........>>>...>>>>>>>>....>>>>>>>..>>.>>>>>>>>.....<<<<.....>>>>.<....<<<<<<<<...>>>>>>>>....>.....>>>>>.....<<<<<<<.........>>>>>>>.....>>>...>>>>>>>>>>.>>....<..<<.<...<<<<<<..<<<<<......<<<....<<.....>>...>>>.......>>>>>.>>>>>>....>.>>...>.....<<<<<<<<<....>>>>>>>>>........ [.[[[[..(((((..]]]]]((((((.((..((.(.(((..(.(((.(((..(......)......(((.......(((.(..((())).)..)))...((((....((..((((....))).)))......)))).((...))))).(((....))).....)))))))......(.(((...(((((....)))).))))).)).).).)).....((((([[[.....(((.....((.]]])).......)))..)))))..)).))))))...((([[...(.((((...(((......(((((((.....(((.(((.((........))..))).))).....).....(.((....))))))))).....)))....))))....((((((...((...((((.........))))...))))))))......{...(.(((((..]]..))))).))))).((.......((((....)))).....))...)))))(((((.(((((((...(((.(((((..((((((((((.....((........))..........(((((((.......((.((....((((((.(....((..(((((.....))).......))..)).....(((....))).....).).)))...))..))))....)))))))..)).)))))))).(...((((.....)))).(....(((((((.....)))))))....)..)..))))).....(((((((.........))))))).....)))...)))))))))).))..(.(..((.(...((((((..(((((..((..(((....((.....))...)))..).)..))))).))))))....).))...)..)..(((((((((....)))))))))}....... Structure of the human mitoribosome with A- P-and E-site mt-tRNAs; 12S rRNA 7a5i 99 73 3.7 RF00005 URS00021ED9B1_9606 33243891 0030533 0006412 9606 guuaauguagcuuaaauuaucaaagcaaggcacugaaaaugccuagaugagccucacagcuccauuaacacca <<<<<<<.................<<<............>>>....................>>>>>>>.... (((((((...................(............)........(..........)..))))))).... Structure of the human mitoribosome with A- P-and E-site mt-tRNAs; mt-tRNA 7a5i 94 73 3.7 RF00005 URS00021ED9B1_9606 33243891 0030533 0006412 9606 guuaauguagcuuaaauuaucaaagcaaggcacugaaaaugccuagaugagccucacagcuccauuaacacca <<<<<<<.................<................>....................>>>>>>>.... (((((((.........................................(..........)..))))))).... Structure of the human mitoribosome with A- P-and E-site mt-tRNAs; mt-tRNA 7a5i X 73 3.7 RF00005 URS00021ED9B1_9606 33243891 0030533 0006412 9606 guuaauguagcuuaaauuaucaaagcaaggcacugaaaaugccuagaugagccucacagcuccauuaacacca <<<<<<<.................<................>....................>>>>>>>.... (((((((.........................................(..........)..))))))).... Structure of the human mitoribosome with A- P-and E-site mt-tRNAs; mt-tRNA 7a5j A 1492 3.1 RF02541,RF02540 URS000080E357_9606 33243891 0003735 0005840 9606 gcuaaaccuagccccaaacccccaccuuacuaccaaaccuuagccaaaccauuuacauaaaguauaggcgauagaaauugggcgcaauagauauaguaccgcaagggaaagaugaaaaaaccaagcauaauauagcaaggacuaaccccuauaccuucugcauaaugaauuaacuagaaauaacuuugcaaggagagccaaagcuaagacccccgaaaccagacgagcuaccuaagaacagcuaagagcacacccgucuauguagcaaaauagugggaagauuuauagguagaggcgacaaaccuaccgagccuggugauagcugguuguccaagauagaaucuuaguucaacuuuaaauuugcccacagaaccaaauccccuuguaaauuuaacuguuaguccaaagaggaacagcucuuuggacacuaggaaaaaaccuuguagagagaguaaaaaauuuaacacccauaguaggccuaaaagcagccaccaauuaagaaagcguucaagcucaacacaaaaaucccaaacauauaacugaacuccucacacccaauuggaccaaucuaucacccuauagaagaacuaauguuaguauaaguaacaugaaaacauucuccuccgcauaagccugcgucagcaacugacaauuaacagcccaauaucuacaaucaaccaacaagucauuauuacccucacugucaacccaacacaggcaugcucauaaggaaagguuaaaaaaaguaaaaggaacucggcaaaucuuaccccgccuguuuaccaaaaacaucaccucuagcaucaccaguauuagaggcaccgccugcccagugacacauguuuaacggccgcgguacccuaaccgugcaaagguagcauaaucacuuguuccuuaaauagggaccuguaugaauggcuccacgaggguucagcugucucuuacuuuuaaccagugaaauugaccugcccgugaagaggcgggcauaacacagcaagacgagaagacccuauggagcuuuaauuuauuaaugcaaacaguaccuaacaaacccacagguccuaaacuaccaaaccugcauuaaaaauuucgguuggggcgaccucggagcagaacccaaccuccgagcaguacaugcuaagacuucaccagucaaagcgaaccucaauugauccaauaacuugaccaacggaacaaguuacccuagggauaacagcgcaauccuauucuagaguccauaucaacaauaggguuuacgaccucgauguuggaucaggacaucccgauggugcagccgcuauuaaagguucguuuguucaacgauuaaaguccuacgugaucugaguucagaccggaguaauccaggucgguuucuaucuacuuuauuccucccuguacgaaaggacaagagaaauaaggccuacuucacaaagcgccuucccccguaaaugauaucaucucaacuuagauacccacacccaagaacaggguu <<<.......<<<<...............................<......>...........<<.....>>.......>>.>>.............<<....>>.................>>>...........<<<.......>>>...<.<........>.>.<<<<<<.........<<<.<<..<<....>>...>>.>>>...<<.<...<<<<.<.....<<<<<.<<<..<<<...>>>...<<<..<<<<........>>>>.>>>....>>>.>>>>>...<<.......>>......>.>>>>......>.>>..<<<<<<....<<<<....>>>><<<.<<<<<<<<<<.....<<......>>.....>>>>>>>>>>..>>>.<<<<<<<<<<......>>>>>>>>>>...<<<......>>>....<<<.<<<...<..............<....<<<.........>>>....>.......<<<......>>>..........................>...>>>>>>........>>>>>>...<<<<<......>>>>>.........>>>>>>.......<<..<<<....>>><<<<..<<<<........<<<<<...>>>>>......<<<...<<<<.......................>>>>.......>>>.....<<......>>.>>>>.....>>>>..<<<<...<<<<<<<<.<<.........<......<<<<<<..<<<.........>>>...<<<<<<.............>>>>>>....<<<.<<<..<<<<<....>>>..>>>>>...<<........>>...........<...........<<<<<<.....>>>>>>.....>....>>>....>>.>>>>.....>..>>.>>>>>>>>>>>>.>>...........<<<<<........>>>>>.......<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<...............<<<....>>>................>>>>>>>>>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<.....<<<..<<<<.....>>>>..>>>....>>...........<....>..............>>>>..>>>>>>.......<<<..<.<<<<<<...<<.......>>...>>>>>>...>.>>.>.......<<<<<.<<<<<<..<<.<<<<<<......>>>>>>...>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>..<<<.<<<.................>>>.>>><<<<<...<<<....>>>.>>>>>......<<<................>>>.........<<<<.......>>>>. ((.....(..((((...............................(...[..).....(.....((.]...))....)..)).)).............((....))....).............)).........(.(((.......))).[.(.(........).).((((((.........(((.((..((....))...)).)))...((.(...((((.(.....(((((.((((.(((..[)))...(((..((((.......{)))).)))..).))).))))).(.((.......))...)..).))))......).))..((((((....((((....)))).((.((((((((((.....((......)).....))))))))))..))..((((((((((......))))))))))...(((......)))....(((.(((...(..............(.(..(((.........)))..).)....(..(((......)))).........................)...))))))........))))))...(((((......))))).........))))))(......((..(((....)))((((..((((......(.(((((...)))))......(((...((((...............(..)....)))).......))).)...((......)).)))).....))))..((((....(((((((.((..(....(........((((((.].((.........))....((((((.............))))))....(((.(((..(((((....)))..)))))..........................((..........(((((.......)))))..)..)....)))....)).))))....)..))).))))))).)))).)).....)).{..(((((.....]}.))))).......((..(((.((......((((.((((((..(((((.((((((((................((....)).................)))))))))))))..(((......[)))((((((..........]))))))(.((.....((...(((....[..)))...))....))...........(....).......)].....))))..))))))......((((..(.((((((.(.((.......)))..))))))...).)).).)......((((.((((((..((.((((((......))))))...)).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..}.))..))).))..(((.(((......(....).....))).)))(((((...(((....))).)))))......(((................))).........((((.......)))). Structure of the split human mitoribosomal large subunit with P-and E-site mt-tRNAs; 16S rRNA 7a5j G 73 3.1 RF00005 URS00021ED9B1_9606 33243891 0030533 0006412 9606 guuaauguagcuuaaauuaucaaagcaaggcacugaaaaugccuagaugagccucacagcuccauuaacacca <<<<<<<.................<.<............>.>......<..........>..>>>>>>>.... (((((((.........................................(..........)..))))))).... Structure of the split human mitoribosomal large subunit with P-and E-site mt-tRNAs; mt-tRNA 7a5k A3 1503 3.7 RF02541,RF02540 URS000080E357_9606 33243891 0003735 0005840 9606 gcuaaaccuagccccaaacccacuccaccuuacuaccagcaaccuuagccaaaccauuuacauaaaguauaggcgauagaaauuguggcgcaauagauauaguaccgcaagggaaagaugaaaaauuauaaccaagcauaauauagcaaggacuaaccccuauaccuucugcauaaugaauuaacuagaaauaacuuugcaaggagagccaaagcuaagacccccgaaaccagacgagcuaccuaagaacagcuaagagcacacccgucuauguagcaaaauagugggaagauuuauagguagaggcgacaaaccuaccgagccuggugauagcugguuguccaagauagaaucuuaguucaacuuuaaauuugcccacagaaccaaauccccuuguaaauuuaacuguuaguccaaagaggaacagcucuuuggacacuaggaaaaaaccuuguagagagaguaaaaaauuuaacacccauaguaggccuaaaagcagccaccaauuaagaaagcguucaagcucaacaccaaaaaucccaaacauauaacugaacuccucacacccaauuggaccaaucuaucacccuauagaagaacuaauguuaguauaaguaacaugaaaacauucuccuccgcauaagccugcgucagaucacacugacaauuaacagcccaauaucuacaaucaaccaacaagucauuauuacccucacugucaacccaacacaggcaugcucauaaggaaagguuaaaaaaaguaaaaggaacucggcaaaucuuaccccgccuguuuaccaaaaacaucaccucuagcaucaccaguauuagaggcaccgccugcccagugacacauguuuaacggccgcgguuaaccgugcaaagguagcauaaucacuuguuccuuaaauagggaccuguaugaauggcuccacgaggguucagcugucucuuacuuuuaaccagugaaauugaccugcccgugaagaggcgggcauaacacagcaagacgagaagacccuauggagcuuuaauuuauuaaugcaaacaguaccuaacaaacccacagguccuaaacuaccaaaccugcauuaaaaauuucgguuggggcgaccucggagcagaacccaaccuccgagcaguacaugcuaagacuucaccagucaaagcgaaccucaauugauccaauaacuugaccaacggaacaaguuacccuagggauaacagcgcaauccuauucuagaguccauaucaacaauaggguuuacgaccucgauguuggaucaggacaucccgauggugcagccgcuauuaaagguucguuuguucaacgauuaaaguccuacgugaucugaguucagaccggaguaauccaggucgguuucuaucuacuuuauuccucccuguacgaaaggacaagagaaauaaggccuacuucacaaagcgccuucccccguaaaugauaucaucucaacuuagauacccacacccaagaacaggguu <<<.......<<<<....................................<......>...........<<.....>>........>>.>>.............<<....>>......................>>>...........<<<.......>>>...<.<........>.>.<<<<<<.........<<<.<<..<<....>>...>>.>>>...<<.<...<<<<.<.....<<<<<.<<<..<<<...>>>...<<<..<<<<........>>>>.>>>....>>>.>>>>>...<<.......>>......>.>>>>......>.>>..<<<<<<....<<<<....>>>><<<.<<<<<<<<<<.....<<......>>.....>>>>>>>>>>..>>>.<<<<<<<<<<......>>>>>>>>>>...<<<......>>>....<<<.<<<...<..............<.....<<.........>>.....>.......<<<......>>>...........................>...>>>>>>........>>>>>>...<<<<<......>>>>>.........>>>>>><......<<..<<<....>>><<<<..<<<<........<<<<<......>>>>>......<<<...<<<<.......................>>>>.......>>>.....<<......>>.>>>>.....>>>>..<<<<...<<<<<<<<.<<.........<......<<<<<<..<<<.........>>>...<<<<<<.............>>>>>>....<<<.<<<..<<<<<....>>>..>>>>><<<<<....>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>....>>.>>>>.....>..>>.>>>>>>>>>>>>.>>.....>.....<<<<<........>>>>>.......<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<...............<<<....>>>................>>>>>>>>>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<.....<<<..<<<<.....>>>>..>>>....>>.........<<<....>>>............>>>>..>>>>>>.......<<<..<.<<<<<<...<<.......>>...>>>>>>...>.>>.>.......<<<<<.<<<<<<..<<.<<<<<<......>>>>>>...>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>..<<<.<<<.................>>>.>>><<<<<...<<<....>>>.>>>>>......<<<................>>>.........<<<<.......>>>>. ((.....(..((((....................................(...[..).....(.....((.]...))....)...)).)).............((....))....).....(...)........)).........(.(((.......))).[.(.(........).).((((((.........(((.((..((....))...)).)))...((.(...((((.(.....(((((.((((.(((..[)))...(((..((((.......{)))).)))..).))).))))).(.((.......))...)..).))))......).))..((((((....((((....)))).((.((((((((((.....((......)).....))))))))))..))..((((((((((......))))))))))...(((......)))....(((.(((...(..............(.(..(((.........)))..).)....(..(((......))))..........................)...))))))........))))))...(((((......))))).........))))))(......((..(((....)))(((...((((......(.(((((......)))))......(((...((((...............(..)....)))).......))).)...((......)).))))......)))..((((....(((((((.((..(....(........((((((.].((.........))....((((((.............))))))....(((.(((..(((((....)))..)))))(((((....)))))........((..........(((((.......)))))..)..)....)))....)).))))....)..))).))))))).)))).)).....)).{..(((((.....]}.))))).......((..(((.((......((((.((((((..(((((.((((((((...............(((....)))................)))))))))))))..(((......[)))((((((..........]))))))(.((.....((...(((....[..)))...))....)).........(((....))).....)].....))))..))))))......((((..(.((((((.(.((.......)))..))))))...).)).).)......((((.((((((..((.((((((......))))))...)).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..}.))..))).))..(((.(((......(....).....))).)))(((((...(((....))).)))))......(((................))).........((((.......)))). Structure of the human mitoribosome in the post translocation state bound to mtEF-G1; 16S rRNA 7a5k A6 928 3.7 RF00177 URS00021ED90F_9606 33243891 0003735 0005840 9606 auagguuugguccuagccuuucuauuagcucuuaguaagauuacacaugcaagcauccccguuccagugaguucacccucuaaaucgaucaaaaggaacaagcaucaagcacgcagcaaugcagcucaaaacgcuuagccuagccacacccccacgggaaacagcagugauuaaccuuuagcaauaaacgaaaguuuaacuaagcuauacuaaccccaggguuggucaauuucgugccagccaccgcggucacacgauuaacccaagucaauagaaccggcguaaagaguguuuuagaucacaauaaagcuaaaacucaccugaguuguaaaaaacuccaguugacacaaaauagacuacgaaaguggcuuuaacauaucugaacacacaauagcuaagacccaaacugggauuagauaccccacuaugcuuagcccuaaaccucaacaguucaacaaaacugcucgccagaacacuacgagccacagcuuaaaacucaaaggaccuggcggugcuucauaucccucuagaggagccuguucuguaaucgauaaaccccgaucaaccucaccaccucuugcucagccuauauaccgccaucuucagcaaacccugaugaaggcuacaaaguaagcgcaaguacccacguaaagacguuaggucaagguguagcccaugagguggcaagaaaugggcuacauuuucuaccccagaaacgauagcccuuaugaaauaagggucgaagguggauuuagcaguaaacuaagaguagagugcuuaguugaacagggcccugaagcgcguacacaccgcccgucacccuccucaaguauacuucaaaggacaauuaacuaaaaccccuacgcauuuauauagaggagacaagucguaacaugguaaguguacuggaaagugcacuuggacgaac ..((((..<<<<<<.)))).<<<<<<.<<..<<<<<<<<..<.<<<.<<<..<......>......<<........<<<....<<..>>....>>>...<<<<....<<...<<<....>>>..>>......>>>>.<<...>>.>>.<<<....>>>.....>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>.....<<<<<<<<.....(((.....((.>>>)).......)))..>>>>>..>>.>>>>>>...<<<((.....<<<<..<<<<......<<<<<<......<<<.<<<.<<<......>>>..>>>.>>>.............<<....>>.>>>>>>.....>>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<.<<<<<..))..>>>>>.>.>>>.<<.......<<<<....>>>>.....>>..>>>>>><<<<<.<<<<<<<...<<<.<<<<<..<<<<<<<<<<.....<<........>>..........<<<<<<<.......<<.<<<..<<<<<<.<.....<<..<<<<<.....>>>.......>>..>>.....<<<....>>>.....>...>>>...>>>>>>>>....>>>>>>>..>>.>>>>>>>>.....<<<<.....>>>>.<....<<<<<<<.....>>>>>>>....>.....>>>>>.....<<<<<<<.........>>>>>>>.....>>>...>>>>>>>>>>.>>....<..<<.<...<<<<<<..<<<<<......<<.....<<.....>>....>>.......>>>>>.>>>>>>....>.>>...>.....<<<<<<<<<....>>>>>>>>>........ [.[[[[..(((((..]]]]]((((((.((..((((((((..(.(((.(((..(......)......(((.......(((.(..((())).)..)))...((((....((..((((....))).)))......)))).((...))))).(((....))).....)))))))......(.(((...(((.(....).)).))))).)).)))))).....((((([[[.....(((.....((.]]])).......)))..)))))..)).))))))...((([[...(.((((...(((......((((((......(((.(((.((........))..))).)))...........(.((....))))))))).....)))....))))....((((((...((...((((.........))))...))))))))......{...(.(((((..]]..))))).))))).((.......((((....)))).....))...)))))(((((.(((((((...(((..((.(..((((((((((.....((........))..........(((((((.......((.(((...((((((.(....((..(((((.....))).......))..)).....(((....))).....).).)))...)).)))))....)))))))..)).)))))))).(...((((.....)))).(....(((((((.....)))))))....)..)..).))......(((((((.........))))))).....)))...)))))))))).))..(.(..((.(...((((((..(((((..((..(((....((.....))...)))..).)..))))).))))))....).))...)..)..(((((((((....)))))))))}....... Structure of the human mitoribosome in the post translocation state bound to mtEF-G1; 12S rRNA 7a5k 24 73 3.7 RF00005 URS00021ED9B1_9606 33243891 0030533 0006412 9606 guuaauguagcuuaaauuaucaaagcaaggcacugaaaaugccuagaugagccucacagcuccauuaacacca <<<<<<<...................<............>........<..........>..>>>>>>>.... (((((((.........................................(..........)..))))))).... Structure of the human mitoribosome in the post translocation state bound to mtEF-G1; mt-tRNA 7a5k FE 73 3.7 RF00005 URS00021ED9B1_9606 33243891 0030533 0006412 9606 guuaauguagcuuaaauuaucaaagcaaggcacugaaaaugccuagaugagccucacagcuccauuaacacca <<<<<<<...................<............>........<..........>..>>>>>>>.... (((((((.........................................(..........)..))))))).... Structure of the human mitoribosome in the post translocation state bound to mtEF-G1; mt-tRNA 7a5p 2 155 5.0 RF00004 URS00021ED9AF_9606 33007253 0045131 0000348 0005686 9606 cgcuucucggccuuucuuaucaguuuaauaucugauacguccucuauccgaggacaauauauuaaauggauuuuuggagcagggagauggaauaggagcuugcuccguccacuccacgcaucgaccugguauugcaguaccuccaggaacggugc ........................<<<<<<<........<<<<<.....>>>>>....>>>>>>>..................<<<.<<<<...<<<<....>>>>.>>>>>>>...<<<<<<.<<<<<.............>>>>>..>>>>>> .......................((((((((.......((((((.....))))))...)))))))).................(((.((((...((((....)))).)))))))....(((((.(((((.............)))))..))))). Human C Complex Spliceosome - Medium-resolution PERIPHERY; U2 snRNA 7a5p 6 16 5.0 RF00026 URS000035C796_9606 33007253 0030621 0000244,0000353 0005688,0046540 9606 gcaaauucgugaagcg ................ ................ Human C Complex Spliceosome - Medium-resolution PERIPHERY; U6 snRNA 7aap T 12 2.5 URS00021ED9B8_2697049 33526596 2697049 uucauaacuuaa ............ ............ Nsp7-Nsp8-Nsp12 SARS-CoV2 RNA-dependent RNA polymerase in complex with template:primer dsRNA and favipiravir-RTP; RNA (5'-R(P*UP*UP*CP*AP*UP*AP*AP*CP*UP*UP*AP*A)-3') 7aav Z 29 4.2 URS00021ED907_32630 33243851 32630 cuccgaacgguaagagccuagcauguaga ............................. ............................. Human pre-Bact-2 spliceosome core structure; MINX M3 pre-mRNA 7aav 2 10 4.2 RF00004 URS00003EE995_9606 33243851 0045131 0000348 0005686 9606 ggcuaagauc .......... .......... Human pre-Bact-2 spliceosome core structure; U2 snRNA 7aav 5 69 4.2 RF00020 URS0000118C49_9606 33243851 0000244,0000353 0005682,0046540 9606 ugguuucucuucagaucgcauaaaucuuucgccuuuuacuaaagauuuccguggagaggaacaacucug ...<<<<<<<<<<........<<<<<<<<.<.......>.>>>>>>>>...>>>>>>>>>>........ ...(((((..(((...((...((((((((.(.......).)))))))).)))))..)))))........ Human pre-Bact-2 spliceosome core structure; U5 snRNA 7aav 6 73 4.2 RF00026 URS000035C796_9606 33243851 0030621 0000244,0000353 0005688,0046540 9606 gugcucgcuucggcagcacauauacuaaaauuggaacgauacagagaagauuagcauccccugcgcaaggaug <<<<<.<<....>>>>>>>........................................<<<.....>>>... (((((.((....)))))))........................................(((.....)))... Human pre-Bact-2 spliceosome core structure; U6 snRNA 7abf 5 58 3.9 RF00020 URS0000118C49_9606 33243851 0000244,0000353 0005682,0046540 9606 uuucucuucagaucgcauaaaucuuucgccuuuuacuaaagauuuccguggagaggaa <<<<<<<<<<........<<<<<<<<...........>>>>>>>>...>>>>>>>>>> .((((..(((...(....((((((((.(.......).))))))))..))))..)))). Human pre-Bact-1 spliceosome core structure; U5 small nuclear RNA 7abf 6 65 3.9 RF00026 URS000035C796_9606 33243851 0030621 0000244,0000353 0005688,0046540 9606 gugcucgcuucggcagcacauauacuaaaauuggaacgauacagagggccccugcgcaaggauga <<<<<.<<....>>>>>>>.............................<.<<<.....>>>..>. (((((.((....))))))).............................(.(((.....)))..). Human pre-Bact-1 spliceosome core structure; U6 small nuclear RNA 7abf Z 29 3.9 URS00021ED907_32630 33243851 32630 cuccgaacgguaagagccuagcauguaga ............................. ............................. Human pre-Bact-1 spliceosome core structure; MINX M3 RNA 7abg 5 114 7.8 RF00020 URS0000118C49_9606 33243851 0000244,0000353 0005682,0046540 9606 acucugguuucucuucagaucgcauaaaucuuucgccuuuuacuaaagauuuccguggagaggaacaacucugagucuuaacccaauuuuuugagccuugccuuggcaaggcua .<<<...<<<<<<<<<<........<<<<<<<<.<.......>.>>>>>>>>...>>>>>>>>>>.......>>>..................<<<<<<<<....>>>>>>>>. .(((....(.((..(((...((...((((((((.(.......).)))))))).)))))..)).)........)))..................((((((((....)))))))). Human pre-Bact-1 spliceosome; U5 snRNA 7abg 2 145 7.8 RF00004 URS00003EE995_9606 33243851 0045131 0000348 0005686 9606 cgcuucucggccuuguaguaucuguucaucaguuuaauaucugaguccucgaggacaggauuuuuggagcagggagauggaauaggagcuugcuccguccacuccacgcaucgaccugguauugcaguaccuccaggaacggugc ............................<.<<........>>>.<<<<<..>>>>>................<<<<.<<<<...<<<<....>>>>.>>>>>>>>..<<<<<<.<<<<<.............>>>>>..>>>>>> ..............................(..........)..(((((())))))................(((..(((....((((....))))..))).)))..(((.((..((((.............))))...)).))) Human pre-Bact-1 spliceosome; U2 snRNA 7abg Z 47 7.8 33243851 32630 cuccgaacgguaagagccuagcauguagaaugaugucauacuuaucc ............................................... ............................................... Human pre-Bact-1 spliceosome; MINX M3 pre-mRNA 7abg 6 78 7.8 RF00026 URS000035C796_9606 33243851 0030621 0000244,0000353 0005688,0046540 9606 gugcucgcuucggcagcacauauacuaaaauuggaacgauacagagggccccugcgcaaggaugaaauucgugaagcg <<<<<.<<....>>>>>>>.............................<.<<<.....>>>..>.............. (((((.((....))))))).............................(.(((.....)))..).............. Human pre-Bact-1 spliceosome; U6 snRNA 7abh Z 28 4.5 33243851 32630 augaugucauacuuauccugucccuuuu ............................ ............................ Human pre-Bact-2 spliceosome (SF3b/U2 snRNP portion); MINX M3 pre-mRNA 7abh 2 37 4.5 RF00004 URS00003EE995_9606 33243851 0045131 0000348 0005686 9606 aaguguaguaucuguucuuaucaguuuaauaucugau ...................<<<<<........>>>>> ...................(((((........))))) Human pre-Bact-2 spliceosome (SF3b/U2 snRNP portion); U2 snRNA 7abi 6 91 8.0 RF00026 URS000035C796_9606 33243851 0030621 0000244,0000353 0005688,0046540 9606 gugcucgcuucggcagcacauauacuaaaauuggaacgauacagagaagauuagcauccccugcgcaaggaugacgcaaauucgugaagcg <<<<<.<<<..>>>>>>>>........................................<<<.....>>>..................... (((((.((....))))))).....................................(..(((.....)))...)................. Human pre-Bact-2 spliceosome; U6 snRNA 7abi 2 164 8.0 RF00004 URS00003EE995_9606 33243851 0045131 0000348 0005686 9606 cgcuucucggccuuuuggcuaagaucaaguguaguaucuguucuuaucaguuuaauaucugauguccucgaggacaggauuuuuggagcagggagauggaauaggagcuugcuccguccacuccacgcaucgaccugguauugcaguaccuccaggaacggugc ..............................................<<<<........>>>>.<<<<<..>>>>>................<<<<.<<<<...<<<<....>>>>.>>>>>>>>..<<<<<<.<<<<<.............>>>>>..>>>>>> ..............................................((((........)))).(((((())))))................(((..(((....((((....))))..))).)))..(((.((..((((.............))))...)).))) Human pre-Bact-2 spliceosome; U2 snRNA 7abi Z 57 8.0 33243851 32630 cuccgaacgguaagagccuagcauguagaaugaugucauacuuauccugucccuuuu ......................................................... ......................................................... Human pre-Bact-2 spliceosome; MINX M3 pre-mRNA 7abi 5 114 8.0 RF00020 URS0000118C49_9606 33243851 0000244,0000353 0005682,0046540 9606 acucugguuucucuucagaucgcauaaaucuuucgccuuuuacuaaagauuuccguggagaggaacaacucugagucuuaacccaauuuuuugagccuugccuuggcaaggcua .<<<...<<<<<<.<<<........<<<<<<<<...........>>>>>>>>...>>>.>>>>>>.......>>>..................<<<<<<<<....>>>>>>>>. .(((...(((((...((...((...((((((((...........)))))))).))))...))))).......)))..................((((((((....)))))))). Human pre-Bact-2 spliceosome; U5 snRNA 7abz 1 2904 3.21 RF02540,RF02541 URS0000B21DEA_83333 34389707 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaacccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccuu <<<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((...<<<......<<<<.<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>.>>>>...>>>.........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>...>.>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<..<<.......>>...>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<<...<............>..>>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>...<<<<........>>>>.))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....[[....>>>>>><...<<<<...<<<<<<<<<<<<..........>>>>>>>>..>>>>...>>>>....>...<<<<......>>>>....>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<..<<....>>...>>>>>........>>>>>>>>..>>>>><<<<<.........>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<.<<...<.............<.<<<..<<.......<<.<............>.>>....>>............>>>..>...>...>>.>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.]].>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>.. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))((((..........)))).((((((((...........)))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(.((.((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))).)).)...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..))))...(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..(((.......))).....)))))))))))))..((.(...((((((.....((((((((((.((((....(((((......)))))....)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....((((......)))).((((((((..((((((((((.....(((...(((.((((...((..((.......))...))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((...(............)..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((..(......)..)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))....(((........)))..]](((((((((((((...((((....((((..(((..(((((.((((((...{{..).))))).((..((((...(((((((((((..((.....)).)))))))..))))..[))))...))(..(((.(....).)))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....((....((((....]))))....))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..((.........(((((..((....))...))))).........)))))))..)))))(.(((.........))).)........((.(......).(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).[..(((((......].)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((....(.(....(...........(.(((..(..........((..(........))).......)....(....)..)))..)..)...)..)...))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..((((((.((......)).)))..))).(((((.....))))).....)))))..)...))..).....(.(((((....))).)).)....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))).. Structure of pre-accomodated trans-translation complex on E. coli stalled ribosome.; 23S ribosomal RNA 7abz 2 1540 3.21 RF00177,RF01959,RF01960 URS000231199F_83333 34389707 0003735 0005840 83333 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggaucaccuccuu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<.<.<<<<......>>>>...>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<.<.<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<.......<<<<....>>>>......>>>...<.<<<<<.....<<.<<<<<<<<.......>>>>>>>>.>>.......>>>>>....>..<<<<<(((...<<<<<.....<..))).>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<....>>>>>>....<<....>>..>>>>>.>>.<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>......<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>.......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<...<<<<.<<<..<<<<<<<<<<<<....<<<<...<<<...<<....>>..>>>..>>>>...>>>>>>>>>>>>..>>>.>>>>....>>...>.....<<<<<<<<<....>>>>>>>>>............. .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((...((..((((......))))...)).))..)))))......(((......(((((((..((...(.(((((.(.((.....((((.(....).))))......)).).....(((....))).....(((((..((....)))))))..))))).)..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((.(.........)))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..(((.........((....))........)))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.((((((..(((((((((.......((((((.....)))))).....)))))))..)).))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((.(.....).))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((.(((((......((........))...........((((((..(.....(..((....((.((....))..))..............))..)...).((.((....((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(.(......))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...))..))).)...))))))....)).))).)))).(....(((((......(((..((...(((....)))...))....)))......)))).)......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((...((((.(((..((((.(((((((....(((((..(((...((....)).).)).)))))...))))))).))))..))).))))....))...)..)..(((((((((....)))))))))}............ Structure of pre-accomodated trans-translation complex on E. coli stalled ribosome.; 16S ribosomal RNA 7abz 3 118 3.21 RF00001 URS0000366A67_83333 34389707 0003735 0005840 83333 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<...<...<<<<<<<<...>>>>>>>>.....>.>>...>>>>>>>>>. (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))). Structure of pre-accomodated trans-translation complex on E. coli stalled ribosome.; 5S ribosomal RNA 7abz 4 363 3.21 RF00023 URS000037602E_83333 34389707 0006401 83333 ggggcugauucuggauucgacgggauuugcgaaacccaaggugcaugccgaggggcgguuggccucguaaaaagccgcaaaaaauagucgcaaacgacgaaaacuacgcuuuagcagcuuaauaaccugcuuagagcccucucucccuagccuccgcucuuaggacggggaucaagagaggucaaacccaaaagagaucgcguggaagcccugccugggguugaagcguuaaaacuuaaucaggcuaguuuguuaguggcguguccguccgcagcuggcaagcgaauguaaagacugacuaagcauguaguaccgaggauguaggaauuucggacgcgggnucaacucccgccagcuccacca <<<<<<<................<<<.<...........<<..........((..<<<<....))........>>>>.............................<.<<......................>>.>.....<...<<<..<<<...((...>>>..>>>.......>.................)).................<<<.........................>>>......<<...<...<<...(..(.>>....>..>>.............)..)...............>>...........>>>.>.....<<<<.........>>>>>>>>>>>.... ((((.((..............(..............(...(...........[...((.....]..........))..............................(..(......................)..).........((...((........[.))...).)........................]......(............[...........)...............]......(.(...(........[....[.....)..)..)..........]...]................)...)............)....((((.........)))))).)))).... Structure of pre-accomodated trans-translation complex on E. coli stalled ribosome.; transfer-messenger RNA (tmRNA) 7abz 7 76 3.21 RF00005 URS00005AA258_83333 34389707 0030533 0006412 83333 gcccgganagcucagucgguagagcaggggauugaanauccccgunnccuuggnucgauuccgaguccgggcacca <<<<.<...<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>.>.>>>>.... .....((..((((.....[..)))).((.(.........).)).....(((((..]....)))))))......... Structure of pre-accomodated trans-translation complex on E. coli stalled ribosome.; tRNA-Phe 7abz 8 15 3.21 34389707 83333 aggaggugagguuuu ............... ............... Structure of pre-accomodated trans-translation complex on E. coli stalled ribosome.; mRNA 7ac7 1 2903 3.08 RF02540,RF02541 URS00021ED9BC_83333 34389707 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaacccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<.......<..<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>..>....>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<........>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<..................................<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<........>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<.<.<<<...<<<....>>>...>>>..>>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<....<<..>>.....>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<..<<<..<<<<<<<..<<<<.......<<<<<<.<<....>>..>>>>>>.......>>>>>>>>>..>>>>>.<<<<<.......>>>>>.........<...........<<<<<<.....>>>>>>.....>.....>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<..<<<.<<<<<.<<<<<<.<<<<.<<<............<<<<<...<........<.<............>.>.....>.............>>>>.>..>>>.>>>>.>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>...>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....((.(.((((((((.((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))((((((......))))))..(((((((...........)))))))..))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(....((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))))))....)...))))...)....((((.((...[........))))))......(((((].[[[[)))))..)))......))..)))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....((((.((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))).))))..((.(...((((((.....(((((((.((.(((....((((.(.......)))))....[)))...(((.(((((........))))))))..).).))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((.((.......)).).))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((..((.....(.....((..(((((..(((.....{.(((((...............................(..(((......)))).)))))...)))..))))).))...........]]].)...))..))))))...)))))))((((..............))))....))))))(.(((((...(((.......(((((((....)))))))....)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]]((((((((...((....(((....((((..(((..((((((((((((...{{{.).))))))((..((((...(((((.((((((.((.....)))))))).)..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....)))....)).......)))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((....((.....].))....)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(.(((.........))).)........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((....(.(..(.(...........(.(((..((.........(..............)......))....(...)...)))..)..))..)..)...))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(.(((((....))).)).)....))..)))))))))))[...(((((((...((((....(((((.....(....)....)))))...(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..)..)))))))). Structure of accomodated trans-translation complex on E. Coli stalled ribosome.; 23S ribosomal RNA 7ac7 2 1540 3.08 RF00177,RF01959,RF01960 URS0000D56C37_83333 34389707 0003735 0005840 83333 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggaucaccuccu ........<<<<....((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<.<<<<........>.>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<..<..<<<<<......>>>>>.....>>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<.<<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>..>>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..))))..<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<...<<<..>>>..>>>>>>>>>...>>>>>>>>>>>>..>>.>>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((.(.(........)..)).)))))..)))))......(((......(((((((..((...(((((((...((.....((((((....))))))......)).......(((....)))....((((((...(....).)))))).)))))))..)).)))))))(((.....((..((((((((.......)))))))))).......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((((.......)))))))).....)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.((((((..((((((((((......((((((.....))))))....))))))))..)).))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((.(((.....))).))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((......(((....)))........(....)...))))).))).((.......((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...))....))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.......((....)).....))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Structure of accomodated trans-translation complex on E. Coli stalled ribosome.; 16S ribosomal RNA 7ac7 3 120 3.08 RF00001 URS0000049E57_83333 34389707 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((.(((((....((((((....(.....)....)))..)))...)))))..)).((.......((((((((...)))))))).......))...)))))))))). Structure of accomodated trans-translation complex on E. Coli stalled ribosome.; 5S ribosomal RNA 7ac7 4 363 3.08 RF00023 URS000037602E_562 34389707 0006401 562 ggggcugauucuggauucgacgggauuugcgaaacccaaggugcaugccgaggggcgguuggccucguaaaaagccgcaaaaaauagucgcaaacgacgaaaacuacgcuuuagcagcuuaauaaccugcuuagagcccucucucccuagccuccgcucuuaggacggggaucaagagaggucaaacccaaaagagaucgcguggaagcccugccugggguugaagcguuaaaacuuaaucaggcuaguuuguuaguggcguguccguccgcagcuggcaagcgaauguaaagacugacuaagcauguaguaccgaggauguaggaauuucggacgcgggnucaacucccgccagcuccacca <<<<<<<.............<<<<<<<............<<...<......((...<<<....))........>>>............<<.......>>.......<.<<...<.............>....>>.>....<...<<<...<<..........>>...>>>.......>....................................<<<.......................>>>.....<<<.......<<<...(....>>>.......>>>..............)........>......>>...........>>>>>>>...<<<<<.......>>>>>>>>>>>>.... ((((((.......[......(((.(((.........(..((.........[.[...(((....]]........)))............(((....).)).......(..(......................)..).........((...((..........))...))................................(............[...........)...............]......(.(............[....[........)..)..........]...]...............))...).......))).)))...(((((..]....))))).)))))).... Structure of accomodated trans-translation complex on E. Coli stalled ribosome.; transfer-messenger RNA (tmRNA) 7ac7 7 76 3.08 RF00005 URS00005AA258_562 34389707 0030533 0006412 562 gcccgganagcucagncggnagagcaggggauugaanauccccgunnccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>><<<<<<<.....>>>>>>.>...<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((.(.........).)).....(((((..]....)))))))))))).... Structure of accomodated trans-translation complex on E. Coli stalled ribosome.; tRNA-Phe 7ac7 8 15 3.08 34389707 562 aggaggugagguuuu ............... ............... Structure of accomodated trans-translation complex on E. Coli stalled ribosome.; mRNA 7acj 1 2903 3.2 RF02540,RF02541 URS00021ED9BC_83333 34389707 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaacccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>....................<<<<<.....<<.....>>....>>>>>...(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<......<<...<<<.<<<<...<<................>>...>>>>.>>>..>>.......>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<...........>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>.>........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<.....<.<...<<<<.....>>>>...>.>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<<.<<....>>..>>>>>>........>>>>>>>>..>>>>>.<<<<<.......>>>>>.........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<.<<.....................<<...........<<<..<<......>>..>>>..................>>...........>>..>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. (..(((((......((((((((((.....(((..(((((((((((((......((((((.[...[[.))).....((.(((...(((]]...].))).......))).))...)))....(((....)))((((((......)))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).)....................(((((.....((.]...))....)))))...((((.(.((......(((.((((.((.(.(.(...(((((......)))))[[(...).(((.....]])))...).)...).)).)))).)))...)).)...)....((.(((((..[......))))).))......((.((].[[[[)).))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..((....((.....))....))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((................))...)))).)))..)).).....)))))).)))..)))))))).)...((((.((((........)))).))))....(((......)))...((((.(((...((.[[[...(.((((((.....(.....((...(.((..(.(.........(((..(...((...........))...).........((........))..))).....).)..)).)..))...........]]].)...))))))).))...)))))))((((.(((......))).))))....))))))(.(((((...(((......((.(.(((....))).).))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((.(...((.....)).).))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]]((((((((.((((...((((....((((..(((..((((((((((((...{{{.).))))))((...(((...((((((((((((.((.....))))))))))..))))..[)))....))(..(((((....)))))...))))))...)))...))))(..).....))))...))....)).)))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((.....(.(((....((.(..)].))....)))..)..))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(..((.........))..)........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.((..(((((.((((((.(....(..................(..(...............(....)............)............).........)....).))))))...(((.((((((.....)))))))))....)))))..))..)))))..(((......[)))((((((..........]))))))(.((...(((((((...(((((.........))))).....((.[.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((.(((..(((((((((......))))))..))).(((((.....))))).....))).)..)...))..).....(.(((((....))).)).)....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).((((....((((...(((((((((((}}}.))))))..)))))...))))..))))...(((....((((.............))))....))).))))..]....)))))))(.((((((..).)))))(....((..(...(.......)...)....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))..). Structure of translocated trans-translation complex on E. coli stalled ribosome.; 23S ribosomal RNA 7acj 2 1534 3.2 RF00177,RF01959,RF01960 URS000081169C_83333 34389707 0003735 0005840 83333 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<....<............>.....>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<..<..<<<<<......>>>>>.....>>>.>.....<<<....>>>....<<<<<<..........>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<....<.<<<<<<.....>>>>>>.>..>>>>>>>..>>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<.<<<<<...<<<<<<<<........<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<.....>>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>......>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>...........>>>>>....<<<<<<<.........>>>>>>>......>....>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>...... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(.(..((.((..(....(............).....)))..))).)......(((......(((((((..((...(((((((...((......(((((....)))).)......)).......(((....)))....(((.((..(......))).))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..(((.......((((....))))......)))...(.(((((...(....((((((((.......)))))))).....)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..((..(((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).))..)..))))...))))....((((((...((...((((.........))))...))))))))......{...((((.(..((((((((((((.....))))))))))))...((..]])).....).)))))))).(((......((((....))))....)))...]]].](((((.(((((((......((.......(((((.(......((........))..........(((((((..(...(((((((..(((.(((....))).)))...(......)..))))).))).((.(((...((((((.(....((((((.((....))....(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)..)))))....(...(.(((.(.....(((..((...(((....)))...))....))).....).))).)...........(((.(............).))).......)....))......(((((((.........)))))))...........)))))))))).))..(.(..((...((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))....))...)..)...((((((((....))))))).)}..... Structure of translocated trans-translation complex on E. coli stalled ribosome.; 16S ribosomal RNA 7acj 3 120 3.2 RF00001 URS0000049E57_83333 34389707 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((.(....(((((.....(.....).....))..)))...).)))).)).((.......((((((((...)))))))).......))...)))))))))). Structure of translocated trans-translation complex on E. coli stalled ribosome.; 5S ribosomal RNA 7acj 4 363 3.2 RF00023 URS000037602E_469008 34389707 0006401 469008 ggggcugauucuggauucgacgggauuugcgaaacccaaggugcaugccgaggggcgguuggccucguaaaaagccgcaaaaaauagucgcaaacgacgaaaacuacgcuuuagcagcuuaauaaccugcuuagagcccucucucccuagccuccgcucuuaggacggggaucaagagaggucaaacccaaaagagaucgcguggaagcccugccugggguugaagcguuaaaacuuaaucaggcuaguuuguuaguggcguguccguccgcagcuggcaagcgaauguaaagacugacuaagcauguaguaccgaggauguaggaauuucggacgcgggnucaacucccgccagcuccacca <<<<<<<..............<<<.<<<.......<<..<<...<<...(.....<<<<......).......>>>>..............................<<<...<<.............>>..>..>>.<<<<<<<<<<...<<....(...>>...>>>>....>>>>>>..............).....<<.....<<<...((...>>>.....>>..............))......<<...........((.............>>................))......>>......>>..>>.....>>.>>>>......<<<<.......>>>>.>>>>>>>.... (((((((......[........(.(((........((..((...(....[[...((((......]]........))))...............................(...((.............))..).....(((((((((....(...[.[....)....)))....)))))).............]...]..((......((...[....))......))...............]......((....(.(............)).....)).........................)......))..))......).)))..........(..]....)....))))))).... Structure of translocated trans-translation complex on E. coli stalled ribosome.; transfer-messanger RNA (tmRNA) 7acr 1 2903 3.44 RF02540,RF02541 URS00021ED9BC_83333 34389707 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaacccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu 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.(.(((((......(((((..(((.....(((..(((((((((((((......((((((.[....[.))).....((((((...(((]....].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((.(......((((.((((..((.(.(...(((((......)))))[[(...).(((.....]])))...).)...))..)))).))))...).))...)....((((((((..[......))))))))......((.((].[[[[)).))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))..))))).....(.((.(...(((((....)))))...).)).[.(.(........).).((((((....(((((((((((((..((....((.....))....))...((....))..(.((.....)).).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((.(......).))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))..(((((((..((((((((((.....(((...(((.((((...((................))...)))).)))..)).).....)))))).)))..)))))))).....(((((((((........)))))))))....(((......)))...((((.(((...((.[[[...(.((((((.....(.....((.....((..(((.....{.(.(((..(.....................)......(..((........))).))).)...)))..))....))...........]]].)...))))))).))...)))))))(((((((((....)))))))))....))))))(.(((((...(((.......(.(.(((....))).).)....)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((..(..((.....)).).))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]]((((((((..(((...((((....((((..(((..((((((((((((...{{..).))))))(...((((...(((.((((((((.((.....))))))))))...)))..[))))....)(...((((....))).)...))))))...)))...))))(..).....))))...))....)..)))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((..(..)]..))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((...(....)....)))))........))))))))..)))))(..((.........))..)........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((((.(....(..................(.................................................).........)....).))))))...(((..(((((.....))))).)))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...((.((((...(((((.........))))).....((][.[[[))....)))).))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((...((..]]]]..))..))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(.(((((....))).)).)....))..)))))))))))[...(((((((...((((..(.(((((.....(....)....))))).).(((((...((((...(((((((((((.}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(.(.(.......).).)....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))..). Structure of post-translocated trans-translation complex on E. coli stalled ribosome.; 23S ribosomal RNA 7acr 2 1534 3.44 RF00177,RF01959,RF01960 URS0002311A31_83333 34389707 0003735 0005840 83333 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaagaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<..<<............>>...>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<..<<<<<<<.......>>>>>>>..>........>>>>>....>..<<<<<(((...<<<<<.....<..))).>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<....<.<<<<<<.....>>>>>>.>..>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>..<<.<<...<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<...<<<.....>>>.>.....>>>>>>.....<<<<<.....>>>>>........>>>>.......>.>>>...>>>.>>>>....>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<...<<<..>>>..>>>>>>>>>...>>>>>>>>>>>>..>>.>>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>...... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(.(..((.((...(...(............)....).))..)).))......(((.......((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....(((.((..(......))).))).)))))))..)).)))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..(((.......((((....))))......)))...(.(((((...(..(.(.((((((.......)))))).).)...)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...(((((((.(...(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((.(..(.((((((((......((........))..........(((.(((..(...(.(((((...((.((......)).))....(......)..)))))..))..(.(.....((((((.(....(((((((((....)))...(((......)))...)))))).....((.(.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..).)).....).).)))...))...).)....)).))))...)).)))))).).(...(.(((.(.....(((..((...(((....)))...))....))).....).))).)......(....(..((((........))))..)....)..)..).))).....(((((((.........)))))))......))...)))))))))).))..(....((.(.((((..((..((((((((((((....((((((.(((...((....))..)))))))))...))))))))))))..))..))))..).))......)...((((((((....))))))).)}..... Structure of post-translocated trans-translation complex on E. coli stalled ribosome.; 16S ribosomal RNA 7acr 3 120 3.44 RF00001 URS0000049E57_83333 34389707 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<......<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>....>>>>>>>>>. ((((((((((.....((((((.(....(((((.....(.....).....))..)))...).)))).)).((.......((((((((...)))))))).......))...)))))))))). Structure of post-translocated trans-translation complex on E. coli stalled ribosome.; 5S ribosomal RNA 7acr 4 363 3.44 RF00023 URS000037602E_562 34389707 0006401 562 ggggcugauucuggauucgacgggauuugcgaaacccaaggugcaugccgaggggcgguuggccucguaaaaagccgcaaaaaauagucgcaaacgacgaaaacuacgcuuuagcagcuuaauaaccugcuuagagcccucucucccuagccuccgcucuuaggacggggaucaagagaggucaaacccaaaagagaucgcguggaagcccugccugggguugaagcguuaaaacuuaaucaggcuaguuuguuaguggcguguccguccgcagcuggcaagcgaauguaaagacugacuaagcauguaguaccgaggauguaggaauuucggacgcgggnucaacucccgccagcuccacca <<<<<<<..............<<................<<...<....((...<<<<<.....)).......>>>>>.............................<.<<..<...............>..>>..>.<<<<<.<<<<..<<....((....>>..>>>>.....>>>>>..............))....<<.....<<<...((...>>>.....>>..............))......<<...........((.............>>................)).......>......>>...............>>....<<<<<.......>>>>>>>>>>>>.... (((((((...............(...(.............(........[....((((.......]........)))).............................(........(........)...........)(((((.(((....(.....[.[..)....))).....))))).............]].....((......((.....[..))......)).............]........((......(.....[......)......))................]...............)............)...).....(.(((.......))).)))))))).... Structure of post-translocated trans-translation complex on E. coli stalled ribosome.; transfer-messenger RNA (tmRNA) 7ajt D2 446 4.6 URS000007769E_559292 33326748 559292 augcgaaagcaguugaagacaagugcuugucguucguuaaaauggccucgucaaacgguggagagagucgcuaggugaucgucagaucugccuagucucuauacagcguguuuaauugacauggguugaugcguauugagagauacaauuugggaagaaauucccagaguguguuucuuuugcguuuaaccugaacagucucaucgugggcaucuugcgauuccauuggugagcagcgaaggauuugguggauuacuagcuaauagcaaucuauuucaaagaauucaaacuugggggaaugccuuguugaauagccggucgcaagacugugauucuucaaguguaaccuccucucaaaucagcgauaucaaacguaccccgugaaacaccgggguaucuguuugguggaaccugauuagaggaaacucaaagagugcuaugguaug .<<<....>>>...<<<<<<<<<..>>>>>>.>>>..............<<<<<<<<.<<...<<<<..<<<<<<<<<<<....>>>>.>>>>>>>>>>>...>>.>>>......>>>>>..<<<<<<..<<<<<..<<<<<.<<<<.<<<<<<<<....>>>>>>>>.>>>>.>>>>>.>>>>>.>>>>>>.......<<<<<<<<<<<...........>>>>>.>>>>>>.........................<<<...>>>.........................<<<<<...<<<<<<..<<<....<<<<<....>>>>>...>>>..>>>>.>>..>>>>>.....<<<<<<.....<<<<<<<<<<<<<<........>>>>>>>.>.>>>>>>......>>>>>>............................. .(((....)))...(((((((((..)))))).)))..............(((((.((.((...((((..(((((((((((....)))).)))))))))))...)).)).......)))))..(((((...(((.(..((((.(((((.((((((((....)))))))).))))).)))).).)))..))))).....(.(((.((.(((((.....)....))))..)).))))........................(((...))).........................(.(.(...(((.(...((((..((((((....))))).)))))...).).))..)..))......(((((.....((((..(((((((((.....).))))))).)...))))......))))).............................. Cryo-EM structure of the 90S-exosome super-complex (state Pre-A1-exosome); 5'ETS RNA 7ajt D3 1327 4.6 RF01960,RF01959,RF00177 URS00021ED968_559292 33326748 0003735 0005840 559292 aagauaguuaucugguugauccugccagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauagcaugguauaacugugguaauucuagagcuaauacaugcuaucucgacccuuuggaagagauuauuuauuagauucuucggacucuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauugcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgauauauuagcauggaauaauaggacguuugguucuauuuuguugguuucuaggaccaucguaauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgaggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggaaacucaccagguccagacacaauauuugugggugguggugcaugugaugcccuuguucuggcgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaaaacuccgucggggaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggaaauuuggacaaacuuggucauuuagaggaacuaaguuuccguaggugaaccugcgga ...........................<<.<<<<<<...<.<..........<<<.<<<..<<....<<....<<..........>>...>>.>>......<<..<.....<<<..<<..<<....<<<.......<<....<<.<<<.....>>>.>>.....>>.....<<<<<..<<....>>..>>>>>...<<<<<<...<<....>>....<<......>>>>>>>>.........<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<.....<......<<<<<<<.......>>>>>>>..>.......>>>...<<<.<<<......>>>....>>>>>>.<<.<<<<........>>>>.>>.<.<......>.>...>>>>>>.........<<<....<<<.....>>>..>>>.......>.>.....<<<<<<<.<<<<<....>>>>>.>>>.>>>>......<<..<...........>..>>.........<<<<<<.......<<<....>>>..................>>>>>>..>>>>>>>>.<.<<...<<<.<<....<<<<<<.<<<<<............>>>>>.>>>>>>..<<<<<.<<...........<<.......>>..<<.....>>............>>.>>..>>>....<<<....<..<<...............>>..>...>>>..>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>..........<<...<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>..>>..................<<.........>>.....<<<<<<<<<<<<..<<.<<<<<...<<<.<<<<........<<<<<......<<<<<...>>>>>......<<...........>>.....>>>>>>>>>.>>>.....<<<<<<<............<<<..<<<<....>>>>..>>>.....>>>>>>>.............>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>............>>>>>..<<<<.<<....<<<<<<<<.<<...<.<<......<<<<<<<....<.<.<......>.>.>....>>>>>>>.....>>.>...>>.>>>>>>>>...>>.>>>>....<<<<<<<<....>>>>>>>> ..............................(.(.((.....(...(......(((.(((..((....((....((..........))...))[))......(((.......(((..((..((....(((.......((....((.(((.....))).)).....)).....(((((..((....))..))))).(.((((((...((....))....((......)))))))).).....(.(.((..((((..).))).)).))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((..(((....))).....)))))).((.((((........)))).)).(.((....)).)...)))))).......(.(((...((((.]...))).))))).)....).......((((((.(((.((....)).)).))).))))......(((.(...........)).))..........(.(((.......(((....)))..................))).)...)).).).....((...(((.((.....(((((.(((((.....().....))))).)))))...((.((.((........(...............((.....))....).......)).))...)).....((..(.((.(((.............))).)).).))...))...(((..(.......((((..((..((((((.....((........))........))))))..))........(....)....))))......)...))..))))...))............((....((...(((((((.(((........))))))))))...))...))..................((.........)).....((((((((((.(..((..((.....(((..(((........(((((.(....(((((...)))))....(.((..((..))...)))..).))))))))..))).....((((.((............(((..((((....))))..))).....)).)))).(....)........)).......((((((.......))))))........))...).)))))............)))))..((((.((....((((((((.(((..(.((..(...((((((..(...(((.(....).)).)..)..))))))..)..)).)..))).))))))))...)).)))).....(((((((....))))))). Cryo-EM structure of the 90S-exosome super-complex (state Pre-A1-exosome); 18S rRNA 7ajt D4 230 4.6 RF01846 URS0000B21E09_559292 33326748 0006396 0005730 559292 gucgacguacuucauaggaucauuucuauaggaaucgucacucuuugacucuucaaaagagccacugaauccaacuugguugaugagucccauaaccuuuguacccgugagaaauagcuugguccgcaauccuuagcgguucggccaucuauaauuuugaauaaaaauuuugccguugcuauggcgcgaugaucuacccauggguggguacaaauggcagucugacaagu .........................................................................<<<<<.................<<<<<<<<<<.<.......<<...<<<.<<<.<<<<......>>>>>>>>>>..>>.<<<<<......>>.>>>..<<<<......>>>>........>.<<<....>>>.>>>>>>>>.>>........>>>>> ..........................................................................(((..................((((((((((((...(...(((..(((.(((.((.((.....)))))))))).))).((((((....))).)))..(((((....))))).)......).((((..))))))))))))).)).........))). Cryo-EM structure of the 90S-exosome super-complex (state Pre-A1-exosome); U3 snoRNA 7aju D2 81 3.8 URS00021ED8F1_559292 33326748 559292 ugcgaaagcaguugaagacaagugcuugucguucguuaaaauggccucgucggauuugguggaaggaaacucaaagagugc <<<....>>>...<<<<<<<<<..>>>>>>.>>>............................................... (((....)))...(((((((((..)))))).)))............................................... Cryo-EM structure of the 90S-exosome super-complex (state Post-A1-exosome); 5'ETS RNA 7aju D3 1409 3.8 RF01960,RF01959,RF00177 URS00021ED8ED_559292 33326748 0003735 0005840 559292 ucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuacaugguauaacugugguaauucuagagcuaauacaugcuaucucgacccuuuggaagagauguauuuauuagauaucuucggacugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuguuguugcaguuaaaaagcucguaguugaacuggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaguuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgauauauuagcauggaauaauaguaggagguucuauucuaggaccaucguauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucugggggaguauggucgcaaggcugaaaaaggaauugacggaagggcaccaccaggaguggagccugcggcgcgcuacacugacggagccagcgagaccuuggccgagaggucuugggaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagauuuggacaaacuuggucauuugaggaacuaauuccguaggugaaccugcggaaggaucauuaaa .<<<<<.......>>>>>.....<<<<<<...<.<..........<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<..<<..<<....<<<..............<.....<<.<<.......>>.>>......>.....<<<<<..<<....>>..>>>>><...<<<<<<....<<....>>.<<......>>>>>>>>.....>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<<..>>>.>...>>>>>>.........<<<....<<<.....>>>..>>>.......>.>.....<<<<<<<.<<<<<....>>>>>.>>>.>>>>......<<..<...........>..>>.........<<<<<<.......<<<....>>>..................>>>>>>..>>>>>>..........<<<((.....<.<<...<<<.<<..<<<<<.<<<<<.....<>.....>>>>>.>>>>>...<<<.<<<<.<..<<..<<<<<.....>>>>>..>>..>.>>>><<<<<.<<.......<<..<<.......>>.<<<.....>>>...>>......>>.>>..>>>....>>>..<<.<<<...>>>.>>.......>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<..(...>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<..)......>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..))>>...>>.....>>>.>>>.................................<<<<<<<<<<<<..<<.<<<<<<..<<<.<<<.>>>.>>>.....<<<<<<<..........<..<<<<....>>>>..>.....>>>>>>>...........<<<<<<.<<....>>.>>>>>>..........>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>............>>>>>..<<<<.<<....<<<<<<<<.<<<..<.<<......<<<<<<<..<.<.<<<......>>>.>.>..>>>>>>>.....>>.>..>>>.>>>>>>>>..>>.>>>>.<<<<<<<<<....>>>>>>>>>........... .(.((.........)).)...(.((((((...(.(...(......(((.(((..((....((....((..........))...))[))......(((.......(((..((..((....(((..............((....((.(((.....))).)).....)).....(((((..((....))..)))))(.(.((((((....((....)).((......)))))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.(((......)))....)))))).((.(((..........))).)).(.((....)).)...)))))).......(.(((...((((.]...))).))))).)....).).....(((((((((((((....))))))))).))))......(((.(...........)).)).........(((((((......(((....)))...............)..))))))..))))))).........((({....(.(.((...(((..(..(((((.(((((....(())....))))).)))))..((((.((((.(..((..(((((.....)))))..))..).))))(((((.((.......((..((.......)).(((.....)))...))......)).))..)))....)))).((.(((...))).)).......)....(((.(((..(...((((..((..((((((.....((...[....))........))))))..)).......((....))...))))..)..)))..))..))))...)).)....((((((....(...((((..]......))))...).))))))......[...(((.((.(((..((((((((.(((........)))))))))))..)))...((...}))...)).....))))))).................................((((((((((((..((..(((((..(((.(((.))).))).(...(((((((.........((..((((....))))..))....)))))))......(....((((((.(......).))))))....)..)..))))).....((((((((.......))))))))......))...))))))).(......)...)))))..((((.((....((((((((.(((..(.((..(...((((((.......((((....)))).......))))))..)..)).)..))).))))))))..)).)))).(((((((((....)))))))))].......... Cryo-EM structure of the 90S-exosome super-complex (state Post-A1-exosome); 18S rRNA 7aju D4 223 3.8 RF01846 URS0000B21E09_559292 33326748 0006396 0005730 559292 gucgacguacuucaaggaucaucuauaggaaucgucacucuuugacucuucccacugaauccaacuugguugaugagucccauaaccuuuguaccccagagugagaaauagcuugguccgcaauccuuagcgguucggccaucuauaauuuugaauaaaaauuuugccguugcuauggcgcgaugaucacccauggguggguacaaauggcagucugacaagu ...............................................................<<<<<.................<<<<<<<<<<<....<........<<..<<<.<<<.<<<<......>>>>>>>>>>.>>..<<<<<<....>>>.>>>..<<<<<....>>>>>........><<<<..>>>>>>>>>>>>>.>>........>>>>> ...............................................................(((((......(..........(((((((((((....(...(....((..(((.(((.((((......)))))))))).))...(((((....))).))...(((((....))))).)......)((((..))))))))))))).))....)...))))) Cryo-EM structure of the 90S-exosome super-complex (state Post-A1-exosome); U3 snoRNA 7am2 R2 34 3.4 URS000080E1E9_5689 33168716 5689 uuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuu .................................. .................................. Intermediate assembly of the Large subunit from Leishmania major mitochondrial ribosome; R2 7aor A 143 3.5 RF02546,RF02545 URS00021ED9B9_353153 33168716 0003735 0005840 353153 uauuauauuuauucauauaauuaauaggauaauauuuguaguuuuugauaccaugauaaggauuauaaauugaaaguguuaauaucauaaucaaaauuuauuauuuauauuaaauauguauguguagauaaaauaagaaauua .......<<<<<...................................................................................................................>>>>>........... .......(((((...................................................................................................................)))))........... mt-SSU from Trypanosoma cruzi in complex with mt-IF-3.; RNA (478-MER) 7aor 2 470 3.5 RF02546,RF02545 URS00021ED9B9_353153 33168716 0003735 0005840 353153 uaaauuauggucaauuguuaguauucauauuaauuuuuuuaaauguuuuaucauuuuauaaagguuuauuuuugaaagauuuuuuguauaaaauuuuaggaauaguuaauaauaauuuauaauuuugauuagauuguuuuguuaaugcuauuagauggguguggaaaaauaaaaaaaauaauuaauauauaucaauaauaaauuaaauuaaucuauuagucagaaauggaugccagccguugcgguaauuucuaugcuuuuaaauauuauacaauuaucauauuaaauuguuaagugcugauuuaaccaauaaaaauauaaauaauuuuuauuuguuuuuaaacaccauuagguauaugcaaauauaaaauuauaguaauuauaaauuauauuaaaaagguauuguugcccaccaauuuuuauaauaaaaauaacgugcaguaauuaauauauuuauaaaaauauauuuu ....................<<<.......<<<<..........................................................<..<<....<<...<<<.......>>>..>>.......>>....>...<<....>>.....................................................................<<<.(...<<<<<.....<<...)>>.......>>>>>>>>.......>>>>............<...................<.......>.....................>............<<<....>>>................<......>..>>>..<<..............>>....<<.<<<..<<<<<<.....>>>>>>...>>>..>>....<<<<<<<<<....>>>>>>>>>.. ....................(((.......((((..........................................................(..((....(....((((...)..)))...).......))....)...(......)...........................................................(..)......((..[...(((((.....((..].)).......))))).)).......))))............(.................................................).............((....)).................(......)..)))...(..............)...(..(.(((...((((.......))))....)))..)..)..(((((((((....))))))))).. mt-SSU from Trypanosoma cruzi in complex with mt-IF-3.; RNA (478-MER) 7aqc A 2820 2.99 RF02540,RF02541,RF00002 URS00021ED9C6_224308 33259811 0003735 0005840 224308 uuaaguuagaaagggcgcacgguggaugccuuggcacuaggagccgaugaaggacgggacgaacaccgauaugcuucggggagcuguaagcaagcuuugauccggagauuuccgaauggggaaacccaccacucguaauggagugguauccauaucugaauucauaggauaugagaaggcagacccggggaacugaaacaucuaaguacccggaggaagagaaagcaaaugcgauucccugaguagcggcgagcgaaacgggaucagcccaaaccaagaggcuugccucuugggguuguaggacacucuguacggaguuacaaaggaacgagguagaugaagaggucuggaaaggcccgccauaggagguaacagcccuguagucaaaacuucguucucuccugaguggauccugaguacggcggaacacgugaaauuccgucggaauccgggaggaccaucucccaaggcuaaauacucccuagugaccgauagugaaccaguaccgugagggaaaggugaaaagcaccccggaaggggagugaaagagauccugaaaccgugugccuacaaguagucagagcccguuaacgggugauggcgugccuuuuguagaaugaaccggcgaguuacgaucucgugcaagguuaagcagaagaugcggagccgcagcgaaagcgagucugaauagggcgcaugaguacguggucguagacccgaaaccaggugaucuacccauguccagggugaaguucagguaacacugaauggaggcccgaacccacgcacguugaaaagugcggggaugagguguggguaggggugaaaugccaaucgaaccuggagauagcugguucucuccgaaauagcuuuagggcuagccucaagguaagagucuuggagguagagcacugauuggacuaggggccccuaccggguuaccgaauucagucaaacuccgaaugccaaugacuuauccuugggagucagacugcgagugauaagauccguagucgaaagggaaacagcccagaccgccagcuaaggucccaaaguauacguuaaguggaaaaggauguggaguugcuuagacaaccaggauguuggcuuagaagcagccaccauuuaaagagugcguaauagcucacuggucgagugacucugcgccgaaaauguaccggggcuaaacguaucaccgaagcugcggacuguucuucgaacagugguaggagagcguucuaagggcugugaagccagaccggaaggacugguggagcgcuuagaagugagaaugccgguaugaguagcgaaagaggggugagaauccccuccaccgaaugccuaagguuuccugaggaaggcucguccgcucaggguuagucgggaccuaagccgaggccgaaaggcguaggcgauggacaacagguugauauuccuguaccaccuccucaccauuugagcaauggggggacgcaggaggauaggguaagcgcgguauuggauauccgcguccaagcaguuaggcugggaaauaggcaaauccguuucccauaagccugagcugugauggcgagcgaaauauaguagcgaaguuccugauuccacacugccaagaaaagccucuagcgaggugagaggugcccguaccgcaaaccgacacagguaggcgaggagagaauccuaaggugaucgagagaacucucguuaaggaacucggcaaaaugaccccguaacuucgggagaaggggugcucuguuagggugcaagcccgagagagccgcagugaauaggcccaggcgacuguuuagcaaaaacacaggucucugcgaagccguaaggcgaaguauaggggcugacgccugcccggugcuggaagguuaagaggagcgcuuagcguaagcgaaggugcgaauugaagccccaguaaacggcggccguaaacgguccuaagguagcgaaauuccuugucggguaaguuccgacccgcacgaaaggcgcaacgaucugggcacugucucaacgagagacucggugaaauuauaguaccugugaagaugcagguuacccgcgacaggacggaaagaccccguggagcuuuacugcagccugauauugaauucuaacccgccgcccuuaucgggcggggagacagugucaggugggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguucccucagaaugguuggaaaucauucgcagaguguaaaggcacaagggagcuugacugcgagaccuacaagucgagcagggacgaaagucgggcuuagugauccggugguuccgcauggaagggccaucgcucaacggauaaaagcuaccccggggauaacaggcuuaucucccccaagaguccacaucgacggggagguuuggcaccucgaugucggcucaucgcauccuggggcuguagucggucccaaggguugggcuguucgcccauuaaagcgguacgcgagcuggguucagaacgucgugagacaguucggucccuauccgucgcgggcgcaggaaauuugagaggagcuguccuuaguacgagaggaccgggauggacgcaccgcugguguaccaguuguucugccaagggcaucgcuggguagcuaugugcggacgggauaagugcugaaagcaucuaagcaugaagccccccucaagaugagauuucccauuccgcaaggaaguaagaucccugaaagaugaucagguugauaggucugagguggaaguguggcgacacauggagcugacagauacuaaucgaucgaggacuuaac <<<<<<......<<<<<<<<<<<....{[[.(((<<<<<<<[[<<......<<<<<<.....((.>>>.....<<<<<<<..<<<)).....>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<<<<<<<<.........>>>>>>>.>>.>>....<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<......<<.....>>.....>>>>...(((....<<<<<<<<<..>>>>>>>>>......<<<<<<<<<.....<<<<.......<<<<<<<<<<.<<<.....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>.>>>>>..>>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.)))..............<<....>>....]].........<<<<....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<......>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<.<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>......>>>>>.>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>...>.>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<...<<<<<<<<<.....<<<...<<<<<<<<...<<.<<<<.....>>>>..>>...>>>>>>>>..>>.>.....>>>>.>>>>>..>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<.........>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<...>>>>>>>....>>>>>>..<<<<<<<.<<......<<<<<.<<....>>.>>>>>...>>.>>>>>>>........>>>>>><......<<....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<.<<<<<<......<<...<<<<....<<<<..<<<..<<<.<.<<<.<.....{....>.>>>.<<..<..<...<<<<.<<<<<<..<<.....>>.>>>>>>....>>>>....>.>...>><..<<...........>>...>>.>>>...>>>...>>>>.........>>>>..>>..>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<<..............<<<<<.....<..>......>>>>><<<<<....<<<<....>>>>...>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>..<<<<.<<<..<<<<<<<..<<<...<<...<<<<<<.<<....>>..>>>>>>...>>...>>>>>>>>..>>>>><<<<<<..>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>...>>.>>>>>>>....>>>.>>>>>>>>.>>>>>>.....>.(...<<<<<.......)>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<<.<<<>>>....<<.<<<<<<.....>>>>>>>>.....>>>>>>>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.}..>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>. .(((((......((((((((((.....(((..(((((((((((((......((((((.....[[[)))...].((((((...(((]].....)))......))))))...)))....(((....)))(((((((......))))))).(((((((((.........))))))).)).))....((((((.....(...[..)......))))).).........((....))...((((......((.]...)).....))))...((((...((((((((....))))))))....{.(((((((((.....((((.......((((((((((.(((...(.((((......)))))[[(...).(((.....]])))...)))...)))))))))))))).)))))..)))))....((((((((..[......))))))))....}.(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((..((((..[...))))..)))).<.(.(........).).((((((....(((((((.(((((..(((...(((.....)))...)))...((....))..((((.....))))......))))).)))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)<)))...(((.(((((.......A))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((...(((((((((.....(((...((((((((...(((((((.....))))).))...))))))))..)).).....)))).)))))..))))))).))..(((((((.((......)).)))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(.(...((.........))...).).....(...((......)).).)))))...)))))))))).))...........]]].)...))))))))))...)))))))(((((((...)))))))....))))))(.(((((...((......(((((.((....))])))))...))...)))))..).....))))))(......((....((((((.......))))))((((....(((...((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((.((((((......((...((((....((((..(((..(((.(.(((..(....{..)...))).((..(......((((.((((.((.((.....))))).)))....))))......)...))(..((...........))...)).)))...)))...))))(..).....))))..))..))))))))))))))).))).....((......))..))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))(((((....((((....))))...)))))(...).......(((((((((.>.((.........))...(((((((.....(((....)))..[....))))))).}((((.(((..(((((((..(((...((...(((((..((....))...)))))...))...))))))))..)))))((((((..))))))........((.(......).(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).[..(((((.....>].)))))..((((((((.(((.((......((((.((((((..(((((.(((((((((.((()))....((.((((((...].)))))))).....)))))))))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..a.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}..))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((....))))....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))...)))))).. Structure of the bacterial RQC complex (Decoding State); 23S ribosomal RNA 7aqc B 112 2.99 RF00001 URS0000BC467F_224308 33259811 0003735 0005840 224308 ugguggcgauagcgaagaggucacacccguucccauaccgaacacggaaguuaagcucuucagcgccgaugguagucggggguuucccccugugagaguaggacgccgccaa <<<<<<<....<<<<<<<<.....<<<<<<.............>>>>..>>....>>>>>>.>>.<<.......<<.<<<<<...>>>>>.>>.......>>..>>>>>>>. (((((((....((((((((.....((((((...(.....)...))))..))....)))))).)).((.......((.(((((...))))).)).......))..))))))). Structure of the bacterial RQC complex (Decoding State); 5S ribosomal RNA 7aqc P 69 2.99 RF00005 URS00002F180C_224308 33259811 0030533 0006412 224308 ggggccuuagcucaggggagagcgccugcucgcaggaggucagcgguucgaucccgcuaggcuccacca <<<<<<<..<<<<......>>>>.<<<<<..>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[..)))).(((((..))))).....(((((..]....)))))))))))).... Structure of the bacterial RQC complex (Decoding State); Ala-tRNA (P-site) 7aqc T 76 2.99 RF00005 URS00002F180C_224308 33259811 0030533 0006412 224308 ggggccuuagcucagcugggagagcgccugcuuugcacgcaggaggucagcgguucgaucccgcuaggcuccacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (.(((((..((((.....[..)))).(((((.......))))).....((((...].....))))))))).).... Structure of the bacterial RQC complex (Decoding State); Ala-tRNA (P-site) 7aqd A 2918 3.1 RF02540,RF02541,RF00002 URS00021ED996_224308 33259811 0003735 0005840 224308 uuaaguuagaaagggcgcacgguggaugccuuggcacuaggagccgaugaaggacgggacgaacaccgauaugcuucggggagcuguaagcaagcuuugauccggagauuuccgaauggggaaacccaccacucguaauggagugguauccauaucugaauucauaggauaugagaaggcagacccggggaacugaaacaucuaaguacccggaggaagagaaagcaaaugcgauucccugaguagcggcgagcgaaacgggaucagcccaaaccaagaggcuugccucuugggguuguaggacacucuguacggaguuacaaaggaacgagguagaugaagaggucuggaaaggcccgccauaggagguaacagcccuguagucaaaacuucguucucuccugaguggauccugaguacggcggaacacgugaaauuccgucggaauccgggaggaccaucucccaaggcuaaauacucccuagugaccgauagugaaccaguaccgugagggaaaggugaaaagcaccccggaaggggagugaaagagauccugaaaccgugugccuacaaguagucagagcccguuaacgggugauggcgugccuuuuguagaaugaaccggcgaguuacgaucucgugcaagguuaagcagaagaugcggagccgcagcgaaagcgagucugaauagggcgcaugaguacguggucguagacccgaaaccaggugaucuacccauguccagggugaaguucagguaacacugaauggaggcccgaacccacgcacguugaaaagugcggggaugagguguggguaggggugaaaugccaaucgaaccuggagauagcugguucucuccgaaauagcuuuagggcuagccucaagguaagagucuuggagguagagcacugauuggacuaggggccccuaccggguuaccgaauucagucaaacuccgaaugccaaugacuuauccuugggagucagacugcgagugauaagauccguagucgaaagggaaacagcccagaccgccagcuaaggucccaaaguauacguuaaguggaaaaggauguggaguugcuuagacaaccaggauguuggcuuagaagcagccaccauuuaaagagugcguaauagcucacuggucgagugacucugcgccgaaaauguaccggggcuaaacguaucaccgaagcugcggacuguucuucgaacagugguaggagagcguucuaagggcugugaagccagaccggaaggacugguggagcgcuuagaagugagaaugccgguaugaguagcgaaagaggggugagaauccccuccaccgaaugccuaagguuuccugaggaaggcucguccgcucaggguuagucgggaccuaagccgaggccgaaaggcguaggcgauggacaacagguugauauuccuguaccaccuccucaccauuugagcaauggggggacgcaggaggauaggguaagcgcgguauuggauauccgcguccaagcaguuaggcugggaaauaggcaaauccguuucccauaagccugagcugugauggcgagcgaaauauaguagcgaaguuccugauuccacacugccaagaaaagccucuagcgaggugagaggugcccguaccgcaaaccgacacagguaggcgaggagagaauccuaaggugaucgagagaacucucguuaaggaacucggcaaaaugaccccguaacuucgggagaaggggugcucuguuagggugcaagcccgagagagccgcagugaauaggcccaggcgacuguuuagcaaaaacacaggucucugcgaagccguaaggcgaaguauaggggcugacgccugcccggugcuggaagguuaagaggagcgcuuagcguaagcgaaggugcgaauugaagccccaguaaacggcggccguaaacgguccuaagguagcgaaauuccuugucggguaaguuccgacccgcacgaaaggcgcaacgaucugggcacugucucaacgagagacucggugaaauuauaguaccugugaagaugcagguuacccgcgacaggacggaaagaccccguggagcuuuacugcagccugauauugaauguugguacagcuuguacaggauagguaggagccuuggaaaccggagcgccagcuucgguggaggcaucggugggauacuacccuggcuguauugaccuucuaacccgccgcccuuaucgggcggggagacagugucaggugggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguucccucagaaugguuggaaaucauucgcagaguguaaaggcacaagggagcuugacugcgagaccuacaagucgagcagggacgaaagucgggcuuagugauccggugguuccgcauggaagggccaucgcucaacggauaaaagcuaccccggggauaacaggcuuaucucccccaagaguccacaucgacggggagguuuggcaccucgaugucggcucaucgcauccuggggcuguagucggucccaaggguugggcuguucgcccauuaaagcgguacgcgagcuggguucagaacgucgugagacaguucggucccuauccgucgcgggcgcaggaaauuugagaggagcuguccuuaguacgagaggaccgggauggacgcaccgcugguguaccaguuguucugccaagggcaucgcuggguagcuaugugcggacgggauaagugcugaaagcaucuaagcaugaagccccccucaagaugagauuucccauuccgcaaggaaguaagaucccugaaagaugaucagguugauaggucugagguggaaguguggcgacacauggagcugacagauacuaaucgaucgaggacuuaac <<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<.....((.>>>.....<<<<<<<..<<<)).....>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<<<<<<<<.........>>>>>>>.>>.>>....<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<......<<.....>>.....>>>>...(((....<<<<<<<<<..>>>>>>>>>......<<<<<<<<<.....<<<<.......<<<<<<<<<<.<<<.....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>.>>>>>..>>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<......>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<.<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>......>>>>>.>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>...>.>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<...<<<<<<<<<.....<<<...<<<<<<<<...<<.<<<<.....>>>>..>>...>>>>>>>>..>>.>.....>>>>.>>>>>..>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<...>>>>>>>....>>>>>>..<<<<<<<.<<......<<<<<.<<....>>.>>>>>...>>.>>>>>>>........>>>>>><......<<....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<.<<<<<<......<<...<<<<....<<<<..<<<..<<<.<.<<<.<.....{....>.>>>.<<..<..<<<<<<<<.<<<<<<..<<.....>>.>>>>>>....>>>>>.>>>.>...>><..<<...........>>...>>.>>>...>>>...>>>>.........>>>>..>>..>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<<..............<<<<<.....<..>......>>>>><<<<<....<<<<....>>>>...>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>..<<<<.<<<..<<<<<<<..<<<...<<...<<<<<<.<<....>>..>>>>>>...>>...>>>>>>>>..>>>>><<<<<<..>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>...>>.>>>>>>>....>>>.>>>>>>>>.>>>>>>.....>.(...<<<<<.......)>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<<.<<<.<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>.>>>....<<.<<<<<<.....>>>>>>>>.....>>>>>>>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.}..>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>. .(((((......((((((((((.....(((..(((((((((((((......((((((.....[[[)))...].((((((...(((]].....)))......))))))...)))....(((....)))(((((((......))))))).(((((((((.........))))))).)).))....((((((.....(...[..)......))))).).........((....))...((((......((.]...)).....))))...((((...((((((((....))))))))....{.(((((((((.....((((.......((((((((((.(((...(.((((......)))))[[(...).(((.....]])))...)))...)))))))))))))).)))))..)))))....((((((((..[......))))))))....}.(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((..((((..[...))))..)))).<.(.(........).).((((((....(((((((.(((((..(((...(((.....)))...)))...((....))..((((.....))))......))))).)))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)<)))...(((.(((((.......A))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((...(((((((((.....(((...((((((((...(((((((.....))))).))...))))))))..)).).....)))).)))))..))))))).))..(((((((.((......)).)))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(.(...((.........))...).).....(...((......)).).)))))...)))))))))).))...........]]].)...))))))))))...)))))))(((((((...)))))))....))))))(.(((((...((......(((((.((....))])))))...))...)))))..).....))))))(......((....((((((.......))))))((((....(((...((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((.((((((......((...((((....((((..(((..(((.(.(((..(....{..)...))).((..(......((((.((((.((.((.....))))).)))....))))......)...))(..((...........))...)).)))...)))...))))(..).....))))..))..))))))))))))))).))).....((......))..))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))(((((....((((....))))...)))))(...).......(((((((((.>.((.........))...(((((((.....(((....)))..[....))))))).}((((.(((..(((((((..(((...((...(((((..((....))...)))))...))...))))))))..)))))((((((..))))))........((.(......).(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).[..(((((.....>].)))))..((((((((.(((.((......((((.((((((..(((((.(((((((((.(((.((((((((((((.(.........(((((..(((......((((((((....))))))))...)))............)))))).)))))))))))).)))....((.((((((...].)))))))).....)))))))))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..a.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}..))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((....))))....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))...)))))).. Structure of the bacterial RQC complex (Translocating State); 23S ribosomal RNA 7aqd B 112 3.1 RF00001 URS0000BC467F_224308 33259811 0003735 0005840 224308 ugguggcgauagcgaagaggucacacccguucccauaccgaacacggaaguuaagcucuucagcgccgaugguagucggggguuucccccugugagaguaggacgccgccaa <<<<<<<....<<<<<<<<.....<<<<<<.............>>>>..>>....>>>>>>.>>.<<.......<<.<<<<<...>>>>>.>>.......>>..>>>>>>>. (((((((....((((((((.....((((((...(.....)...))))..))....)))))).)).((.......((.(((((...))))).)).......))..))))))). Structure of the bacterial RQC complex (Translocating State); 5S ribosomal RNA 7aqd T 76 3.1 RF00005 URS00002F180C_224308 33259811 0030533 0006412 224308 ggggccuuagcucagcugggagagcgccugcuuugcacgcaggaggucagcgguucgaucccgcuaggcuccacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).(((((.......))))).....((((...].....))))))))))).... Structure of the bacterial RQC complex (Translocating State); Ala-tRNA (A/P-site) 7as8 2 73 2.9 RF00005 URS00002F180C_224308 33259810 0030533 0006412 224308 ggggccuuagcucaggggagagcgccugcuuugcacgcaggaggcagcgguucgaucccgcuaggcuccacca <<<<<<<..<<<<......>>>>.<<<<<.......>>>>>....<<<<<.......>>>>>>>>>>>>.... ((.(((...((((...[..))))..((((.......)))).....(((((..]....))))).))).)).... Bacillus subtilis ribosome quality control complex state B. Ribosomal 50S subunit with P-tRNA, RqcH, and RqcP/YabO; tRNA-Ala-1-1 7as8 A 2812 2.9 RF02540,RF02541,RF00002 URS00021ED966_224308 33259810 0003735 0005840 224308 guuaaguuagaaagggcgcacgguggaugccuuggcacuaggagccgaugaaggacgggacgaacaccgauaugcuucggggagcuguaagcaagcuuugauccggagauuuccgaauggggaaacccaccacucguaauggagugguauccauaucugaauucauaggauaugagaaggcagacccggggaacugaaacaucuaaguacccggaggaagagaaagcaaaugcgauucccugaguagcggcgagcgaaacgggaucagcccaaaccaagaggcuugccucuugggguuguaggacacucuguacggaguuacaaaggaacgagguagaugaagaggucuggaaaggcccgccauaggagguaacagcccuguagucaaaacuucguucucuccugaguggauccugaguacggcggaacacgugaaauuccgucggaauccgggaggaccaucucccaaggcuaaauacucccuagugaccgauagugaaccaguaccgugagggaaaggugaaaagcaccccggaaggggagugaaagagauccugaaaccgugugccuacaaguagucagagcccguuaacgggugauggcgugccuuuuguagaaugaaccggcgaguuacgaucucgugcaagguuaagcagaagaugcggagccgcagcgaaagcgagucugaauagggcgcaugaguacguggucguagacccgaaaccaggugaucuacccauguccagggugaaguucagguaacacugaauggaggcccgaacccacgcacguugaaaagugcggggaugagguguggguaggggugaaaugccaaucgaaccuggagauagcugguucucuccgaaauagcuuuagggcuagccucaagguaagagucuuggagguagagcacugauuggacuaggggcccggguuaccgaauucagucaaacuccgaaugccaaugacuuauccuugggagucagacugcgagugauaagauccguagucgaaagggaaacagcccagaccgccagcuaaggucccaaaguauacguuaaguggaaaaggauguggaguugcuuagacaaccaggauguuggcuuagaagcagccaccauuuaaagagugcguaauagcucacuggucgagugacucugcgccgaaaauguaccggggcuaaacguaucaccgaagcugcggacuguucgaacagugguaggagagcguucuaagggcugugaagccagaccggaaggacugguggagcgcuuagaagugagaaugccgguaugaguagcgaaagaggggugagaauccccuccaccgaaugccuaagguuuccugaggaaggcucguccgcucaggguuagucgggaccuaagccgaggccgaaaggcguaggcgauggacaacagguugauauuccuguaccaccuccucaccauuugagcaauggggggacgcaggaggauaggguaagcgcgguauuggauauccgcguccaagcaguuaggcugggaaauaggcaaauccguuucccaaaggcugagcugugauggcgagcgcgaaguuccugauuccacacugccaagaaaagccucuagcgaggugagaggugcccguaccgcaaaccgacacagguaggcgaggagagaauccuaaggugaucgagagaacucucguuaaggaacucggcaaaaugaccccguaacuucgggagaaggggugcucuguuagggugcaagcccgagagagccgcagugaauaggcccaggcgacuguuuagcaaaaacacaggucucugcgaagccguaaggcgaaguauaggggcugacgccugcccggugcuggaagguuaagaggagcgcuuagcguaagcgaaggugcgaauugaagccccaguaaacggcggccgucgguccuaagguagcgaaauuccuugucggguaaguuccgacccgcacgaaaggcgcaacgaucugggcacugucucaacgagagacucggugaaauuauaguaccugugaagaugcagguuacccgcgacaggacggaaagaccccguggagcuuuacugcagccugauauugaauguugguuugaccuucuaacccgccgcccuuaucgggcggggagacagugucaggugggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguucccucagaaugguuggaaaucauucgcagaguguaaaggcacaagggagcuugacugcgagaccuacaagucgagcagggacgaaagucgggcuuagugauccggugguuccgcauggaagggccaucgcucaacggauaaaagcuaccccggggauaacaggcuuaucucccccaagaguccacaucgacggggagguuuggcaccucgaugucggcucaucgcauccuggggcuguagucggucccaaggguugggcuguucgcccauuaaagcgguacgcgagcuggguucagaacgucgugagacaguucggucccuauccgucgcgggcgcaggaaauuugagaggagcuguccuuaguacgagaggaccgggauggacgcaccgcugguguaccaguuguucugccaagggcaucgcuggguagcuaugugcggacgggauaagugcugaaagcaucuaagcaugaagccccccucaagaugagauuucccauuccgcaaggaaguaagaucccugaaagaugaucagguugauaggucugagguggaaguguggcgacacauggagcugacagauacuaaucgaucgaggacuuaacc <<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<..[..((.>>>.....<<<<<<<..<<<))..]..>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<<<<<<<<.........>>>>>>>.>>.>>....<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<......<<.....>>.....>>>>...(((....<<<<<<<<....>>>>>>>>......<<<<<<<<<.....<<<<.......<<<<<<<<<<.<<<.....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>.>>>>>..>>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<......>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<.<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>......>>>>>.>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<...<<<<<<<<<.....<<<...<<<<<<<<...<<<<<<..>>>>.>>...>>>>>>>>..>>.>.....>>>>.>>>>>..>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<..>>>>>>....>>>>>><.<<<<<<<.<<......<<<<<.<<....>>.>>>>>...>>.>>>>>>>..>.....>>>>>><......<<....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<.<.<<<...<<<....>>>...>>>..>>>...<<<<<........>>>>>))<<<<..<<<<<<......<<...<<<<....<<<<..<<<..<<<.<<<<<<<<...(((....>>>>>><<..<<<<<..<<<<<<<<<<<.<<.....>>>>>>>>>...>>>>..>>>>>...>><..<..>...>>>>>>...>>>...>>>>.........>>>>..>>..>>>>>>.>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<<<<....<<<<....>>>>...>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>..<<<<.<<<..<<<<<<<..<<<<..<<...<<<<<<.<<....>>..>>>>>>...>>..>>>>>>>>>..>>>>><<<<<.>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>...>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<<.<<<.<<<<...>>>>.>>>....<<.<<<<<<.....>>>>>>>>.....>>>>>>>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.)))>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>>. (((((((......((((((((((.....(((..(((((((((((((......((((((..[..[[[)))...].((((((...(((]]..]..)))......))))))...)))....(((....)))(((((((......))))))).(((((((((.........))))))).)).))....((((((.....(...[..)......))))).).........((....))...((((......((.]...)).....))))...((((...(((((((((..)))))))))....{.(((((((((.....((((........(((((((((.(((...(.((((......)))))[[(...).(((.....]])))...)))...))))))))).)))).)))))..)))))....((((((((..[......))))))))....}.(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((..((((..[...))))..)))).<.(.(........).).((((((....(((((((.(((((..(((...(((.....)))...)))...((....))..((((.....))))......))))).)))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)<)))...(((.(((((.......A))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((...(((((((((.....(((...((((((((...((..((()))...))...))))))))..)).).....)))).)))))..))))))).))..(((((((.((......)).)))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((.(.....{.(((((.(((..(((.........)))..))).....(...((......)).).)))))...).)))))))).))...........]]].)...))))))))))...)))))))((((((()))))))....))))))(((((((((.((......(((((.((....))])))))...)).))))))).)).....))))))(......((....((((((.......))))))((((....(((...((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((.((((((......((...((((....((((..(((..(((.((((((((....{{....))))))((..(((((..(((((((((((.((.....)))))))))...))))..)))))...))(..(())...))))))...)))...))))(..).....))))..))..))))))))))))))).))).....((......))..))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.[..).....)))))(((((....((((....))))...)))))(...).......(((((((((.>.((.........))...(((((((.....(((....))).......))))))).]((((.(((..(((((((..(((...((...(((((..((....))...)))))...))...))))))))..)))))(((((.)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).[..(((((.....>].)))))..((((((((.(((.((......((((.((((((..(((((.(((((((((.(((.((.(...).)).)))....((.((((((.....)))))))).....)))))))))..)))))..(((......[)))((((((..........]))))))([((...(((((((...((.((.........)).)).....((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..a.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..((((....))))....(((.(((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))....)))....))))))). Bacillus subtilis ribosome quality control complex state B. Ribosomal 50S subunit with P-tRNA, RqcH, and RqcP/YabO; 23S rRNA 7as8 B 112 2.9 RF00001 URS00001CC3E3_224308 33259810 0003735 0005840 224308 ugguggcgauagcgaagaggucacacccguucccauaccgaacacggaaguuaagcucuucagcgccgaugguagucggggguuucccccugugagaguaggacgccgccaa <<<<<<<....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<.....<.<<.<<<<<...>>>>>.>>...>...>>..>>>>>>>. (((((((....((((((((.....((((((...(.....)...))))..))....)))))).)).((.......((.(((((...))))).)).......))..))))))). Bacillus subtilis ribosome quality control complex state B. Ribosomal 50S subunit with P-tRNA, RqcH, and RqcP/YabO; 5s rRNA 7as9 2 75 3.5 RF00005 URS00002F180C_224308 33259810 0030533 0006412 224308 ggggccuuagcucagcgggagagcgccugcuuugcacgcaggaggucagcgguucgaucccgcuaggcuccacca <<<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((....[..)))).(((((.......))))).....(((((..]....)))))))))))).... Bacillus subtilis ribosome-associated quality control complex state A. Ribosomal 50S subunit with peptidyl tRNA in the A/P position and RqcH.; tRNA-Ala-1-1 7as9 A 2812 3.5 RF02540,RF02541,RF00002 URS00021ED966_224308 33259810 0003735 0005840 224308 guuaaguuagaaagggcgcacgguggaugccuuggcacuaggagccgaugaaggacgggacgaacaccgauaugcuucggggagcuguaagcaagcuuugauccggagauuuccgaauggggaaacccaccacucguaauggagugguauccauaucugaauucauaggauaugagaaggcagacccggggaacugaaacaucuaaguacccggaggaagagaaagcaaaugcgauucccugaguagcggcgagcgaaacgggaucagcccaaaccaagaggcuugccucuugggguuguaggacacucuguacggaguuacaaaggaacgagguagaugaagaggucuggaaaggcccgccauaggagguaacagcccuguagucaaaacuucguucucuccugaguggauccugaguacggcggaacacgugaaauuccgucggaauccgggaggaccaucucccaaggcuaaauacucccuagugaccgauagugaaccaguaccgugagggaaaggugaaaagcaccccggaaggggagugaaagagauccugaaaccgugugccuacaaguagucagagcccguuaacgggugauggcgugccuuuuguagaaugaaccggcgaguuacgaucucgugcaagguuaagcagaagaugcggagccgcagcgaaagcgagucugaauagggcgcaugaguacguggucguagacccgaaaccaggugaucuacccauguccagggugaaguucagguaacacugaauggaggcccgaacccacgcacguugaaaagugcggggaugagguguggguaggggugaaaugccaaucgaaccuggagauagcugguucucuccgaaauagcuuuagggcuagccucaagguaagagucuuggagguagagcacugauuggacuaggggcccggguuaccgaauucagucaaacuccgaaugccaaugacuuauccuugggagucagacugcgagugauaagauccguagucgaaagggaaacagcccagaccgccagcuaaggucccaaaguauacguuaaguggaaaaggauguggaguugcuuagacaaccaggauguuggcuuagaagcagccaccauuuaaagagugcguaauagcucacuggucgagugacucugcgccgaaaauguaccggggcuaaacguaucaccgaagcugcggacuguucgaacagugguaggagagcguucuaagggcugugaagccagaccggaaggacugguggagcgcuuagaagugagaaugccgguaugaguagcgaaagaggggugagaauccccuccaccgaaugccuaagguuuccugaggaaggcucguccgcucaggguuagucgggaccuaagccgaggccgaaaggcguaggcgauggacaacagguugauauuccuguaccaccuccucaccauuugagcaauggggggacgcaggaggauaggguaagcgcgguauuggauauccgcguccaagcaguuaggcugggaaauaggcaaauccguuucccaaaggcugagcugugauggcgagcgcgaaguuccugauuccacacugccaagaaaagccucuagcgaggugagaggugcccguaccgcaaaccgacacagguaggcgaggagagaauccuaaggugaucgagagaacucucguuaaggaacucggcaaaaugaccccguaacuucgggagaaggggugcucuguuagggugcaagcccgagagagccgcagugaauaggcccaggcgacuguuuagcaaaaacacaggucucugcgaagccguaaggcgaaguauaggggcugacgccugcccggugcuggaagguuaagaggagcgcuuagcguaagcgaaggugcgaauugaagccccaguaaacggcggccgucgguccuaagguagcgaaauuccuugucggguaaguuccgacccgcacgaaaggcgcaacgaucugggcacugucucaacgagagacucggugaaauuauaguaccugugaagaugcagguuacccgcgacaggacggaaagaccccguggagcuuuacugcagccugauauugaauguugguuugaccuucuaacccgccgcccuuaucgggcggggagacagugucaggugggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguucccucagaaugguuggaaaucauucgcagaguguaaaggcacaagggagcuugacugcgagaccuacaagucgagcagggacgaaagucgggcuuagugauccggugguuccgcauggaagggccaucgcucaacggauaaaagcuaccccggggauaacaggcuuaucucccccaagaguccacaucgacggggagguuuggcaccucgaugucggcucaucgcauccuggggcuguagucggucccaaggguugggcuguucgcccauuaaagcgguacgcgagcuggguucagaacgucgugagacaguucggucccuauccgucgcgggcgcaggaaauuugagaggagcuguccuuaguacgagaggaccgggauggacgcaccgcugguguaccaguuguucugccaagggcaucgcuggguagcuaugugcggacgggauaagugcugaaagcaucuaagcaugaagccccccucaagaugagauuucccauuccgcaaggaaguaagaucccugaaagaugaucagguugauaggucugagguggaaguguggcgacacauggagcugacagauacuaaucgaucgaggacuuaacc <<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<..[..((.>>>.....<<<<<<<..<<.))..]...>>.....>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<<<<<<<<.........>>>>>>>.>>.>>....<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<......<<.....>>.....>>>>...(((....<<<<<<<<....>>>>>>>>......<<<<<<<<<.....<<<<.......<<<<<<<<<<.<<<.....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>.>>>>>..>>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<......>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<.<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>......>>>>>.>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<...<<<<<<<<<.....<<<...<<<<<<<<...<<.<<<..>>>..>>...>>>>>>>>..>>.>.....>>>>.>>>>>..>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>...>>>>>>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<..>>>>>>....>>>>>><.<<<<<<<.<<......<<<<<.<<....>>.>>>>>...>>.>>>>>>>..>.....>>>>>><......<<....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>....<<<<........>>>>.))<<<<..<<<<<<......<<...<<<<....<<<<..<<<..<<<.<<<<<<<<...(((....>>>>>><<..<<<<<..<<<<<<<<<<<.<<.....>>>>>>>>>...>>>>..>>>>>...>><.........>>>>>>...>>>...>>>>.........>>>>..>>..>>>>>>.>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<....<<<<....>>>>...>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>..<<<<.<<<..<<<<<<<..<<<...<<...<<<<<<.<<....>>..>>>>>>...>>...>>>>>>>>..>>>>><<<<<.>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>...>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<<.<<<.<<<.....>>>.>>>....<<.<<<<<<.....>>>>>>>>.....>>>>>>>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<.<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>..>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.)))>>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>>. (((((((......((((((((((.....(((..(((((((((((((......((((((..[..[[[)))...].((((((...(((]]..]..)))......))))))...)))....(((....)))(((((((......))))))).(((((((((.........))))))).)).))....((((((.....(...[..)......))))).).........((....))...((((......((.]...)).....))))...((((...(((((((((..)))))))))....{.(((((((((.....((((.......((((((((((.(((...(.((((......)))))[[(...).(((.....]])))...)))...)))))))))))))).)))))..)))))....((((((((..[......))))))))....}.(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((..((((..[...))))..)))).<.(.(........).).((((((....(((((((.(((((..(((...(((.....)))...)))...((....))..((((.....))))......))))).)))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)<)))...(((.(((((.......A))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((...(((((((((.....(((...((((((((...((..((()))...))...))))))))..)).).....)))).)))))..))))))).)...(((((((.((......)).)))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(.((((((.(.....{.(((((.(((..(((.........)))..))).....(...((......)).).)))))...).)))))).).))...........]]].)...))))))))))...)))))))((((((..))))))....))))))(((((((...((......(((((.((....))])))))...))...))))).)).....))))))(......((....((((((.......))))))((((....(((...((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((.((((((......((...((((....((((..(((..(((.((((((((....{{....))))))((..(((((..(((((((((((.((.....)))))))))...))))..)))))...))(..(..)...))))))...)))...))))(..).....))))..))..))))))))))))))).))).....((......))..))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.[..).....)))))(((((....((((....))))...)))))(...).......(((((((((.>.((.........))...(((((((.....(((....))).......))))))).]((((.(((..(((((((..(((...((...((((...((....))....))))...))...))))))))..)))))(((((.)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).[..(((((.....>].)))))..((((((((.(((.((......((((.((((((..(((((.(((((((((.(((.((.(...).)).)))....((.((((((.....)))))))).....)))))))))..)))))..(((......[)))((((((..........]))))))([((....((((((...((.((.........)).)).....((][.[[[))....))))))....((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..a.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..((((....))))....(((.(((((.......)))))....(((.((((.(((....(((((....)))))...)))..))))..)))....)))....))))))). Bacillus subtilis ribosome-associated quality control complex state A. Ribosomal 50S subunit with peptidyl tRNA in the A/P position and RqcH.; 23S rRNA 7as9 B 112 3.5 RF00001 URS00001CC3E3_224308 33259810 0003735 0005840 224308 ugguggcgauagcgaagaggucacacccguucccauaccgaacacggaaguuaagcucuucagcgccgaugguagucggggguuucccccugugagaguaggacgccgccaa <<<<<<<....<<<<<<<<.....<<<<<<.............>>>>..>>....>>>>>>.>>.<<.....<.<<.<<<<<...>>>>>.>>...>...>>..>>>>>>>. (((((((....((((((((.....((((((...(.....)...))))..))....)))))).)).((.......((.(((((...))))).)).......))..))))))). Bacillus subtilis ribosome-associated quality control complex state A. Ribosomal 50S subunit with peptidyl tRNA in the A/P position and RqcH.; 5S rRNA 7ase 1 75 3.33 RF00005 URS00021ED904_5693 33357443 0030533 0006412 5693 agcaccguggcgcaguggaagcgcgaugggcucauaacccauaggacguuggaucgaaaccaaccggugcuacca <<<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((....[..)))).(((((.......))))).....(((((..]....)))))))))))).... 43S preinitiation complex from Trypanosoma cruzi with the kDDX60 helicase; initiator tRNA-Met 7ase 0 2150 3.33 RF01960,RF01959,RF00177 URS0000CBFF1F_5693 33357443 0003735 0005840 5693 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...<<<<<...{{{{>>>>>{{{{.[[[[[[...[[[..........[[[.[[[..<<....<<....<<<<...>>>>...>>.>>......{{........[[[..[[..[[...[[.[[.....<<<<<<...>>>>>>...<<.....<<<<<<.....>>>>>>......>>..........<<<<<.<<<.......<<<<<<<<<....>>>>>>>>>...>>>>>>>>.[[((((((((......<<<<<<<<<<<<......>>>.........................))))))))...]]....<<<<<<........>>>>>>...]].]]..]]]]..]]].<<<....<<<....<<<<<.<<.......>>.>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.}}.<<.<<<..........>>>.>>.<<<<....>>>>...]]]]]].........<<<....<<<..........>>>..>>>.......]]]....<<<.<<<<<<<<<....>>>>>>>>>..>>>.....<<<<............>>>.....>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..]]]]]]}}}}.........{{{{{.....[[[[...[[[.......<<<<<.<.<<<<.<<<..<<............................>>..>>>>>>>>.>>>>>..........................<<<<<<..<....<<<<.<.........<<<<.......>>>>..>>>>>.>>>>>>>.....<<<<<<<<.......<<...<.......>..<<<....>>>.....>>......>>>>>..>>>...........[[..(((((..<<<...>>>.((..>>>>>>>>>))..)))))..]].......<<<<<...<<<....<<<<<..<<<..>>>.>>>>>..<<<>>>..>>>.>>.>>>............<<<<<..<<...<<<<<<<<..<<<<<<<<...<<<......>>>......>>>>>>>.>.>>.......<<....>>.>>>>>>..>>.>>>.>>....]]]...]]]]...<<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>>.........<<<.<<...<..<<<<<.......<<<.<<.<<<<<.<<..<<<...<............>..>>>...>>.>>>>>>>>>>...........................<.<<...<<<<<<<.........>>>>>>>.........>>.>................>>>>>..>......<<..}}>>.....>>.....>>>.}}}.<<<......<<<<....>>>>....>>>..}}}}..<<<<<.<<<<<<<..<<.<<<<<<.....<<<<<<.......<<........>>.......<..<<.<<......<.<<<........<<.<<<........>>>.>>......>>>.>.<.<<.<<<..<<.<<<<<<....<<<.<<<<......>>...<<<......>>>...>>.>>>....<<<<<.<<<<.....<<<<<.<<..<.....<<<<<<<..<<<<...>>>>..>>>>>>>......>....>>.>>>>>.....>>>>...<<.<.<<.....>>>.>>.......>>>>>....>>>.>>>.....>>>>>>>>......>.>.>>.>...>.>>>>>........................................<<<<<<<........>>>>>>>............................<....<<<.<<..........>>.>>>.....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<<<<<..<<.<<<.<.<<<<..<<<<<.<...<.<<<<<<<<...>>>>>>>>.>...>.>>>>>..>>>>.>.>>>.>>..>>>>>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))((((.((((((...(((...((.....(((.(((..((....((....((((...))))...)){))......(((.......(((..((..((...((.((.....((((((...))))))...((.....((.(((.....))).))......))..........(((((.((((......(((((((((....)))))))))..))))))))).((((((((((.......[[[.[[[[(((......)))................(......).))))))))...))....((((((........))))))...)).))..))))..))).(((....(((....(((((.((.......)).))))))))......)))..(((.((((....))))....)))))).((.(((..........))).)).((((....))))...)))))).).....(.(((...((((.}........))).))))).)....)))....(((..((((((((....))))))))...)))...(.((((............))).....)......)..(..(([[....(.((((.....((..]])).......)))))))..)..))))))))))..{......((({{...(.((((...(((..(....(((((....(((.(((.(............(.......)............)))))))...)))))(..................)......((((((...(...((((...........((((.......))))...))))).)))))).....((((((((.......((..((.......)).(((....))).....))......)))))..)))...........((..(((((..((.....)).....]]]].]]].....)))))..)).......(((((...(((....(((.(.((((()))))).)))..((()))..))).)).))).....)....(.(.(((..((...(((((((((..(((((((...((........))......)))))))..))).......((....)).))))))..)).)))..)...))))...))))....((((((....(...((((.........))))...).))))))......<...(((.((...((....(..(...(..((.((.((((..(...(((...................)))....)..)))))))).)........................(..(((....(.((((.........)))).)..........)))..)............)..)....))......((..}})).....))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(.(((.....(((((((......((........))..........((..(.(....(.(..........((.(((........))).)).........))...((.(((...(.((((((....(((.(((((....)))....((......))....)).))).....((((.((((.....(((((.((..(.....(((((((..(((.....)))..)))))))......)....)).))))).....))))......(.((.....)))..........)))).....))).))).....).))))).....).)...))....)).))))).........................................(((.((........)).))).............................(....((..((..........))..)).....).....))).).....(((.(((.........))).)))......))...)))))))))).))..(.(..((.(.((((((((..((.(((.(.(((((.(((((.(...(.((((((((...)))))))).)...).)))))).)))).).))).))..))))))))..).))...)..)..(((((((((....)))))))))>........ 43S preinitiation complex from Trypanosoma cruzi with the kDDX60 helicase; 18S 7asm A 2834 2.48 RF02540,RF02541,RF00002 URS00001C3329_1280 0003735 0005840 1280 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<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[.<......<<<<<<.[...((.>>>.....<<<<<<<..<<<))...].>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<<<<<<<<.........>>>>>>>.>>.>.....<<<<<......<<....>>.......>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..(((....<<<<<<<<....>>>>>>>>......<<<<<<<<<...<<<<.......<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>.>>>>>..>>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<....>>>>..................>>>>>>>>>>>.......<<<<..<<<<......>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<.<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>.>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<.>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<...<<<<<<<<<.....<<<...<<<<<<<<...<<.........>>...>>>>>>>>..>>.>.....>>>>>.>>>>..>>>>>>>.>>..<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<.<<<<........<..>....>>>>.>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<...>>>>>>>....>>>>>><.<<<<<<<.<<......<<<<<.<<....>>.>>>>>...>>.>>>>>>>..>.....>>>>>><......<<....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<..........<<<...<<<<....<<<<...<<...<....<.<<<...{.{...>>>.>.<....<<<<...<<<.<<<<<<..>>>>>>......>>>...>>>>.....>..........................>....>>...>>>>.........>>>>..>>>.....>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<.......>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<..<.........>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<<...........>>>>>>...>>...>>>>>>>>..>>>>><<<<<.....>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<<.<<<<.<<<<<<<<<..............<<<..<<.........<<<<<<....>>>>>>......>>............>>>....>.>>>>>>>>.>>>>....<<.<<<<<<.....>>>>>>>>.....>>>>>>>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.}.}>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<....>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>. ((((((......((((((((((.....(((..((((((((.((.(......((((((.[[..[[[)))...].((((((...(((]]..]].)))......))))))...)))....(((....)))(((((((......))))))).(((((((((.........))))))).)).).....(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...((((((((....))))))))....[.(((((((((....((((.....)((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))..)))))..)))))....(((((((...{.......)))))))....].(((((}.[[[[)))))..)))......))..)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).......((((..((((..[...))))..)))).{.(.(........).).((((((....(((((((.(((((..(((...(((.....)))...)))...((....))..((((.....)))).....))))).)))))))..((.(...((((((.....((((((((((.((((...((((((.))))))...){)))...(((.(((((........))))))))..).))))))))).(.(((....[)))...).]))))))......).))..((((((....(.(((....))).)(.(((((((...(((((((((.....(((...((((((((...((.........))...))))))))..)).).....))))).))))..)))))))..)..((((((((((......))))))))))....(((......)))...((.(.(((...(((.[[...(.(((.((.....(.....((..((((.(((((.......(())...))))).)))).))...........]]..)...)).)))))))...)))).))(((((((...)))))))....))))))(.(((((((.((......(((((.((....))])))))...)).)))))))..).....))))))(......((....((((((.......))))))((((....(((...((...((((((...((.....)).))))))....[[((((..(.(.(((...(((....)))...)))..))....(((((........)))))]](((((((..(........((...((((....(((((..((...(....(.(.......<.....).)..(....(((....((.((((.(()).))))......))....))).....)...........................)....))..)))))(..).....))))..))...)..)))))))))))..)).....((......))..))).(((.......)))..))))..((((....((((((((.((..(....(.......(((((....(.[..).....)))))(((((((.((.......).).)))))))(...).......(((((((((.}.(...........)...(((((((.....(((....))).......))))))).]((((..((..(((((((..(((...((...(..((.............))..)...))...))))))))..)))).(((((.....)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)..[..(((.(.....}].).)))..((((((((.(((.((......((((.((((((..(((((.(((((((((.((((.(((.((((....................(.(.......(..((((....))))..)....).)....................).))).))).)))).....(.((((((.....)))))))......)))))))))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....))..)))))))))))[...(((((((...(.((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.>..))))))..)))))...)))).)))))...(((....((((.............))))....))).)).)..]....))))))).(((....)))....(((((((((.......)))))....((.((((..(((....(((((....)))))...)))...))))..))...))))....)))))). Staphylococcus aureus 50S after 30 minutes incubation at 37C; 23S rRNA 7asm B 115 2.48 RF00001 URS0000062A7E_1280 0003735 0005840 1280 ucuggugacuauagcaaggaggucacaccuguucccaugccgaacacagaaguuaagcuccuuagcgucgaugguagucgaacuuacguuccgcuagaguagaacguugccaggc <<<<<<<<<....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<......<<<.<<<<....>>>>.>>>......>>..>>>>>>>>>. .(((((.((....((((((((.....(((((....(.....)....)))..))....)))))).)).((.......((.((((....)))).)).......))..)).))))).. Staphylococcus aureus 50S after 30 minutes incubation at 37C; 5S rRNA 7asn A 2742 2.73 RF02540,RF02541,RF00002 URS00023119DB_1280 0003735 0005840 1280 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Staphylococcus aureus 50S after 30 minutes incubation a 37C; 23S 7asn B 106 2.73 RF00001 URS0002311A28_1280 0003735 0005840 1280 ggugacagcaaggaggucacaccuguucccauccgaacacagaaguuaagcuccuuagcgucgaugguaucgaacuuaguuccgcuagaguagaacguugccaggc <<<.<<.<<<<<<<......<<<<<..............>>>..>>.....>>>>>.>>.<<.......<.<<<<...>>>>.>........>>..>>.>>>.... (((..(.(((..(..........(((...(....)...)))...........)..).)).((.......(.((((...)))).)........))..)..))).... Staphylococcus aureus 50S after 30 minutes incubation a 37C; 5S 7aso C 114 3.11 RF00001 URS00003DF33D_1280 0003735 0005840 1280 ucuggugacuauagcaaggaggucacaccuguucccaugccgaacacagaaguuaaggucuuuagcgacgaugguagccaacuuacguuccgcuagaguagaacguugccaggc ..<.<..........<<<<<......<<<<<...............>>>..>>.....>>>>>...<....<......<............>.......>...>.....>.>.. .((.(..........(...(.....(...((....(.....)....))........).)...)..............................................).)). Staphylococcus aureus 70S after 30 minutes incubation at 37C; 5S 7aso X 1415 3.11 RF00177,RF01959,RF01960 URS00023119D5_1280 0003735 0005840 1280 auggagaguuugauccuggcucaggaugaacgcuggcggcgugccuaauacaugcaagucgagcgaacguuagcggcggacgggugaguaacacguggauaaccuaccuauaagacugggauaacuucgggaaaccguagcuaauaccggauaauauagugaaagacacuuauagauggauccgcgcugcauuagcuaguugguaagguaacggcuuaccaaggcaacgaugcauagccgaccugagagggugaucggccacacuggaacugagacacgguccagacuccuacgggaggcagcaguagggaaucuuccgcaaugggcgaaagccugacggagcaacgccgcgugagugaugaaggucuaucguaaaacucuguuauuagggagaacauaugucacaucuugacguaccuaaucagaaagccacggcuaacuacgugccagcagccgcgguaauacguagguggcaagcguuauccggaauuauugggcguaaagcgcgcguaggcgguuuuuuaagucugaugugaaagcccacggcucaaccguggagggucauuggaaacuggaaaacuugagugcagaagaggaaaguggaauuccauguguagcggugaaaugcgcgagauauggaggaacaccaguggcgaaggcgacuuucuggucuguaacugacgcugaugugcgaaagcguggggaucaaacaggauuagauacccugguaguccacgccguaaacgaugagugcuaaguguuagggggugccccuuagugcugcagcuaacgcauuaagcacuccgccuggggaguacgaccgcaagguugaaacucaaaggaauugacggggacccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaaaucuugacaucacaaagugacagguggugcaugguugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuuaagcuuaguugccaucauuaaguugggcacucuaaguugacugccggugacaaaccggaggaagguggggaugacgucaaaucaucaugccccuuaugauuugggcuacacacgugcuacaauggacaauacaaagggcagcgaaaccgcgaggucaagcaaucccauaaaguuguucucaguucggauuguagucugcaacucgacuacaugaagcuggaaucgcuaguaaucguagaucagcaugcuacggugaauacguucccgggucuuguacacaccgcccgucacaccacgagguuuguaacacccgaagccgguggaguaaccuuuuaggagcuagccgucgaaggugggacaaaugggggugaagucguaacaagguagccguaucggaaggugcggcuggau ......((...<..<<<..))...<....<<<<..<<<<<<.<.....<<<.......<<..............>>.......<<..........<<<.........<<......<...........<<<....>>>............>.......................>>......>>>...<<<...........<.................>...........>>>..<<..<<........>>.....>>.>>.<<<<..<.........>.>>>>...<......>........>>>..........<......<<......>>....>...>..>>>>>>.....<.......<....>......>...............................................................<<<......................>>>........>>>>....>...........<.<<.....<.<....<<..<<<<.....<<...............<<<<.....>>>>...............>>....>>>>...<<<.<<<<...<.....................<.<......>.>........................<......>.......>..>>>>..>>>....>>....>.>..............<...<<<<.........>>>>...>.................[...((...<<.<<...<.<..>.>...>>.>>....((..>>)).....))...]..>....<........<......>......>....>>>..>...<...<<.<<.......<<.......<<...................................<<......................<<.<<...<<...........<<<<<<<<<....>>>....<<......>>....>>>>>>.....<.<<..............................................<<.....>>...........>>.>................>>.>>>>.......>>...........>>....................<..........<......>..........>.........................<<<..............>>>.............>>.......<...<...........>...>.............>>.>>..>........<.........<<......<.......<<.....<.<<<...<<<............>>>..>>>.>....>>......>.....>>...........>........<<<..........>>>....... ......((...[.......))...(....((((...((.((.......(((........(..............)........(((..........(((....(...(((.....(...........(((....)))............)......................)))...).)))....(.(............(...(.......)....)...........).)..(.....((....).).......)))).((.(..............).))...(......)........)))..........(....((.((....)).).).)......)).))................................................................................(...[[...(((((.....((.].])).......)))))...)...))))....).....................(.........((((....((.(..(..........(.((.......))..)........).)...))...))))..(..(.(((....((...(.(........(.....(..........).........)......).......((....))..)...))...)))..)....)........)...............(...((((.........))))...).................(...(...((.(((....(....)....))).))...((....))......)...).......(........((....))......).........]...(......(........(......................(........).........................(.......)...((.(............(....(((..(.((....)).....(........)....)..))).....(.(.............(............)..............(.....(.......).....)......).).....)..............)))..........................(........(............................................)..........(.....((................)).....)..).....)........(..((.........))...)..............).....)........(..........(.(.............(.(...(.((....((..............))...)).)...))...........).)............).....(..(....(....)....)..).... Staphylococcus aureus 70S after 30 minutes incubation at 37C; 16S 7aso Y 2720 3.11 RF02540,RF02541 URS00023119FC_1280 0003735 0005840 1280 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.(..((......((((((((((.....(((..((((((((.((.(......((((((.[[..[[[)))...].(..((....(((]]..]].))).......))..)...)))....(((....)))(.(.(((......))).).).((........................)).).....(((((......(...[..).......)))).)..........(....)....((((......((.]...)).....))))...((((...(.(..............).)....[.(((((((.(....................((.(.....(((((......)))))[.......(((......]))).....)...)).............).)))..)))))....(((((((...{.......)))))))....].(((((}...[[)))))..)))......))..)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((..((((..[...))))..)))).{.(.(........).).((((((....(((((((.(((((..(((...((.......))...)))...((....))...(((.....)))......))))).)))))))..((.(...((((((.....((((((((((.((((.................){)))...(((.(((((........))))))))..).))))))))).(.((.......))...)..))))))......).))..((((((....(((((....)))))(((((((((...(((((((((.....(((...(((((.(............).)))))..)).).....)))).)))))..))))))).))..(((((.((((......)))).)))))....(((......)))...((.(.(((...((([[[...(.((((((.....(.....((..(.((.(.......................).)).).))...........]]].)...))))))))))...)))).)).(((........))).....))))))(.(((((((.((......(((((.((....))])))))...)).)))))))..).....))))))(......((....((((((.......))))))((((....((((..((...((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((..........(.(....(((((........(...(............).(..............................................)................).........)))))(..).....)..)............)))))))))..)).....((......)).)))).(((.......)))..))))..((((....((((((((.((..(....(.......(((((....(.[..).....)))))((((((....(.......)...))))))(...).......(((((((((.}.((.........))...(((((((.....(((....))).......))))))).]((((..((..(((((((..(((....(..........(......)...........)....))))))))..))))..(..........)........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).[..(((((.....}].)))))..((((((((.(((.((......((((.((((((..(((((.((.((((((.((((.((.((.((((..)))).)).)).))))....(..(...............)).....)))))).))..)))))..(((......[)))((((((..........]))))))([.(....((((((.(..(((...........)))....).(.][.[[[.)....))))))....((((..(((...{..)))..)))).(((....))).).]]].].....((.(.....(..]]....)....).)).....)}......))))..))))))......(((((.(.((((((...(.........)...))))))...)))).).)......((((.((((((..((((((............)))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((...............))))))).(((((...((((...((((((((((......)))))..)))))...)))).)))))...(((.....(((.............))).....))).))))..]....)))))))(.............(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))...)))..).. Staphylococcus aureus 70S after 30 minutes incubation at 37C; 23S 7asp Y 2723 2.86 RF02540,RF02541 URS00001450D9_1280 0003735 0005840 1280 uuaaguuauuaagggcgcacgguggaugccuuggcacuagaagccaaugaaggacguuacuaacgacgauaugcuuuggggagcuguaaguaagcuuugauccagagauuuccgaauggggaaacccagcaugaguuaugucauguuaucgauauguuagcauaucagaaggcacacccggagaacugaaacaucuuaguacccggaggaagagaaagaaaauucgauucccuuaguagcggcgagcgaaacgggaagagcccaaaccaacaaguugcuuguugggguuguaggacacucuaugaguuacaaaggacgacauuagacgaaucaucuggaaagaugaaucaaagaagguaauaauccuguagucgaaaauguugucucucuugaguggauccugaguacgacggagcacgugaaauuccgucggaaucugggaggaccaucuccuaaggcuaaauacucucuagugaccgauagugaaccaguaccgugagggaaaggugaaaagcaccccggaaggggagugaaauagaaccugaaaccgugugcuuacaaguagucagagcccguuaaugggugauggcgugccuuuuguagaaugaaccggcgaguuacgauuugaugcaagguuaagcaguaaauguggagccguagcgaaagcgagucugaauagggcguuuaguauuuggucguagacccgaaaccaggugaucuacccuuggucagguugaaguucagugaauggaggaccgaaccgacuuacguugaaaagugagcggaugaacugaggguagcggagaaauuccaaucgaaccuggagauagcugguucucuccgaaauagcuuuagggcuagccucaagugaugauuauuggagguagagcacuguuuggacgaggccgaauucagacaaacuccgaaugccaauuaauuuaacuugggagucagaacaugggugauaagguccguguucgaaagggaaacagcccagaccaccagcuaaggucccaaaauauauguuaaguggaaaaggauguggcguugcccagacaacuaguagucgagugacacugcgccgaaaauguaccggggcuaaacauauuaccgaagcugugauuguccuuuggacaaugguaggagagcguucuaagggcguugaagcaugaucguaaggacauguggagcgcuuagaagugagaaugccggugugaguagcgaaagacgggugagaaucccguccaccgauugacuaagguuuccagaggaaggcucguccgcucuggguuagucggguccuaagcugaggccgacaggcguaggcgauggauaacagguugauauuccuguaccaccuauaaucgaucgauggggggacgcaguaggauaggcgaagcgugcgauuggauugcacgucuaagcaguaaggcugaguaggcugagcugugauggggagaagacucuucgagucguugauuucacacugccgagaaaagccucuagauagaaaauaggugcccguaccgcaaaccgacacagguagucaagaugagaauucuaaggugagcgagcgaacucucguuaaggaacucggcaaaaugaccccguaacuucgggagaaggggugcucuuuaggguuaacgcccagaagagccgcagugaauaggcccaagcgacuguuuaucaaaaacacaggucucugcuaaaccguaaggugauguauaggggcugacgccugcccggugcuggaagguuaagaggagugguuagcuucugcgaagcuacgaaucgaagccccaguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgacccgcacgaaaggcguaacgauuugggcacugucucaacgagagacucggugaaaucauaguaccugugaagaugcagguuacccgcgacaggacggaaagaccccguggagcuuuacuguagccugauauugaaauucggcacagcuagcuguguuggcuuucuaacccgcaccacuuaucguggugggagacagugucaagcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcucaaagguucccuagaaugguuggaaaucauucauagaguguaaaggcauaagggagcuugacugcgagaccuacaagucgagcagggucgaaagacggacuuagugauccggugguuccgcauggaagggccaucgcucaacggauaaaagcuaccccggggauaacaggcuuaucucccccaagaguucacaucgacggggagguuuggcaccucgaugucggcucaucgcauccuggggcuguagucggucccaaggguugggcuguucgcccauuaaagcgguacgcgagcuggguucagaacgucgugagacaguucggucccuauccgucgugggcguaggaaauuugagaggagcuguccuuaguacgggaccgggauggacauaccucugguguaccaguugucgugccaacggcauagcuggguagcuauguguggacgggauaagugcugaaagcaucuaagcaugaagccccccucaagaugagauuucccaacuucgguuauaagaucccucaaagaugaugagguuaauagguucgagguggaagcauggugacauguggagcugacgaauacuaaucgaucgaagacuuaau <<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.....((.>>>.....<<<...<..<<<)).....>>>.....>...>>>...>>>....<<<....>>>.....................<<.................>>.>>.....<.<<......<......>......>>.>............<.....>...<<<<<......<<.....>>.....>>>>>..(((....<.<..<<<...>>>.>.>.......<<<<<<......................<....<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>......>..............>>..>>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<....>>>>..................>>>>>>>>>>>.......<<<<..<<<<......>>>>..>>>>...<.<........>.>.<<.<<<....<<<<<<<.<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>.>>>>>>>..<......<<<<<<.....<<<<<<<<<..<<<....<<<<...>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>........>..<.<.<......<<<<<....>>>>><<<<<<<<<...<<<<<<<<<.....<<<...<<<<<<<............>>>>>>>..>>.>.....>>>>.>>>>>..>>>>>>>.>>..<<<<<<<<<<......>>>>>>>>>>....<<<......>>>....<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<.<<.........................>>.>>>>.>>...........))).....>>>>>>.>>>...>>>>>>..<...<....>...>......>.>.><.<<<<<<<.<<......<<<<<.<<....>>.>>>>>...>>.>>>>>>>..>.....>>>.>><......<<....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<..<....<.....>...>.>>>....((<<<<<<<.<.<<<...<<<....>>>...>>>..>>>>..<<<<<........>>>>>))<<<<<<............<<<<.....<<<<........................................<...<<.........>>...>..............<....>..................>>>>..........>>>>...........>>>>>>>>>>..>>.....<<......>>>>>>>.<<<.......>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<<...<.......>..>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<......<<<...<....>...>.>>......>...>>>>>>>>..>>>>>...........................<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<.<<<<<<.<<<<.<<<<<.<<<<..>>>>.>>>>>.>>>>....<<.<<<<<<.....>>>>>>>>.....>>>>>>.>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<..<<...............>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>.....<<<<<....<<<<..<.......................>..<<<<<...<<<<...<<<<<<<<<<......>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>.>>>>>>........>>>>>................<<<<<<<<.........>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>. (((.((........((((((((......((....((.(((.((((......((((((.....[[[)))...].((........((]].....))...........))...)))....(((....)))(.................)..((.................)).)).....(.((......(...[..)......)).).......................((((......((.]...)).....))))...((((...(.(....(...)...).).....[.(((((.(.....................(....(((...(((((......))))).[......(((.....].)))...)))......).............).)..)))))....(((((((...{.......)))))))....].(((((}.[[[[)))))..)))......))..))).))..................((....))....)).........((((....))))...................)))))))).......(.((((..((((..[...))))..))))...(.(........).).((.(((....((((((..(((((...((...(((.....)))...))....((....))...(((.....)))......)))))..))))))..(......((((((.....(((((((((..((((...(..(...)..)...)<)))...(((.((.((.......{)).)))))...{)))))))))....((.....)).......))))))........).............(((((....)))))((..(((((...(((((((((.....(((...(((.((..............)).)))..)).).....))))).))))..)))))...))..(((((.((((......)))).)))))....(((......)))....(((.(((...((([[[...(.(((((......(.....((..((((.(...(.......(.......)...)...).)))).))...........]]].)....)))))))))...))))))..(...(...)....)...........(.(((((.(..(......(((((.((....))])))))...)..).)))))..).....))).))(......((....(.((((.......)))).)((((....((((..((...((.(..................)))....[[((..(((.(.(((...(.(....).)...)))..))))..(((((........)))))]]((((((...((...(...((((.....((((......................A...............(((...((.........))...))..)..................................)))).(..).....))))..)...))...))))))..))..)).....((......)).)))).(((.......)))..))))..((((....((((((((.....(....(.......(((((....(.[..).....)))))(((((((...(........).)))))))(...).......(((.(((((.>}((.........))...(((((((.....(((....))).......))))))).]((.(..((..(.((((....((...(.....(.(...(......)....).).....)...))..))))...))).(...................)......((..........(((...........)))..)..)....).))...)).))).))).)..)...)))))))).)))))).....)).[..(((.(......].).)))..(((((((..(((.((......((((.((((((..(((((.((.((((((.((((..((.(..((....))..).))..))))....((.((((.(.....).)))))).....)))))).))..)))))..(((......[)))((((((..........]))))))([.(...(((((((...(...............)......(.]..[.[.)....)))))))...((((..(((...{..)))..))))..(......)..).].]........((((((.((..]]]]..))))))))......)}......))))..))))))......(((((.(.(((.((...((.......))...)).)))...)))).).)......((((.((((((..((((((((........)))))..))).(((((.....))))).....)))))..)...))).)......((((((....))).)))...}.))..))).))))))).....(((((....(((...............(.)............(((((...((((....(((((((((..a...)))))..))))....)))).)))))...(((....((((.............))))....).)).)))........)))))................(((((((((.......)))))....((((((((.(((....(((.(....).)))...)))..))))).)))...))))....)).))). Staphylococcus aureus 70S after 50 minutes incubation at 37C; 23S rRNA 7asp X 1447 2.86 RF00177,RF01959,RF01960 URS000066D7CD_1280 0003735 0005840 1280 auggagaguuugauccuggcucaggaugaacgcuggcggcgugccuaauacaugcaagucgagcgaacguuagcggcggacgggugaguaacacguggauaaccuaccuauaagacugggauaacuucgggaaaccguagcuaauaccggauaauauagaaagacacuuauagauggauccgcgcugcauuagcuaguugguaagguaacggcuuaccaaggcaacgaugcauagccgaccugagagggugaucggccacacuggaacugagacacgguccagacuccuacgggaggcagcaguagggaaucuuccgcaaugggcgaaagccugacggagcaacgccgcgugagugaugaaggucuucggaucguaaaacucuguuauuagggagaacauaugugcacaucuugacguaccuaaucagaaagccacggcuaacuacgugccagcagccgcgguaauacguagguggcaagcguuauccggaauuauugggcguaaagcgcgcguaggcgguuuuuuaagucugaugugaaagcccacggcucaaccguggagggucauuggaaacuggaaaacuugagugcagaagaggaaaguggaauuccauguguagcggugaaaugcgcagagauauggaggaacaccaguggcgaaggcgacuuucuggucuguaacugacgcugaugugcgaaagcguggggaucaaacaggauuagauacccugguaguccacgccguaaacgaugagugcuaaguguuagggggugccccuuagugcugcagcuaacgcauuaagcacuccgccuggggaguacgaccgcaagguugaaacucaaaggaauugacggggacccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaaaucuugacauccuuugacaacucuagagauagagccuaaagugacagguggugcaugguugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuuaagcuuaguugccaucauuaaguugggcacucuaaguugacugccggugacaaaccggaggaagguggggaugacgucaaaucaucaugccccuuaugauuugggcuacacacgugcuacaauggacaauacaaagggcagcgaaaccgcgaggucaagcaaucccauaaaguuguucucaguucggauuguagucugcaacucgacuacaugaagcuggaaucgcuaguaaucguagaucagcaugcuacggugaauacguucccgggucuuguacacaccgcccgucacaccacgagaguuuguaacacccgaagccgguggaguaaccuuuuaggagcuagccgucgaaggugggacaaaugauuggggugaagucguaacaagguagccguaucggaaggugcggcuggau ......<<<....[....>>>..<<...<<<.<...<<..........<<<.......<................>.......<<........<..<<....<<....<<<..................<....>..................................>>>...>>.>.>..>..<<....<<...........................>>......>>...<<<<.<<<....>>>....>>>>.>>.<<<<<.<.........>>>>>>..<<.....>>........>>>.........<<<....<<<<....>>>>..>>>........>>.....<<.......<<......>>......>>...................................................<<<<<.((....<<<<........))..........>>>>.>>>>>..>.>>>..>>.............<<..................<<<......<.......................................>........>>>.............................<<.......<........>..........>>........................................................................<<<<.........>>>>.........................((...............................((..>>)).....))..........<........<<<....>>>......>.....].........<<<.........<<<<<....<<<<<<.................................<<<.......<<.<<......<<<<......>>>>....>>..>>...........<<.<<<........<.<<............................>>>........<<<..............................................<<<.....>>>...........>>>.......>.>>....>>...........>>>.........>>>>>>...................<<...........................>>...........................<<..........>>..............>>>>>...........................................>>>............<.......<..<<....<<<<<..<<<<....<.<<<<<..................>.>>>>.>...>>>>..>>>>>....>>.>........>...........<<<<..........>>>>...... ......(.............)..(((..(((.....((.(........(((......(..................)......(((.......(..((((...(.....((.............(...((....))...).............................))....).))))..)...(....(.....(..(..((......)).)..)...)......)....((((..(......).....))))))).(((((.(.........))))))...((....))........))).......(.(((...(((.(....).)).))))).....).))...............(......).............................................................((((.[[....(((.........]]...........))).)))).....))).))).............[[.............(.....((......................................................).)......(...........(.........(..(.......((......))..........)..).........................)...........).....)...........................(((.........)))..........................(....(......................)....((..]]))......)..........(........(((....)))......).............(..(...........(((.......(((..(...............................(.........((..........((.(....).)).........))..(........((..((.(.....(....................................)......(((.............................................(.(.......)....).......))).....).).).....)).....).......)......)...))).....(...............((....(................).....)).......................(....................).......)...)))........(..................).................).).........(............(.....(((((..(.((....(.((((.....................)))).)...)).)..))))).....)..............).....(.((((.(.....)..)))).).... Staphylococcus aureus 70S after 50 minutes incubation at 37C; 16S rRNA 7asp 3 114 2.86 RF00001 URS00003DF33D_1280 0003735 0005840 1280 ucuggugacuauagcaaggaggucacaccuguucccaugccgaacacagaaguuaaggucuuuagcgacgaugguagccaacuuacguuccgcuagaguagaacguugccaggc .<<.<..<.....<<<<<<<......<<<<<...............>>>..>>.....>>>>>.>><...........<............>...........>..>..>.>>. .(..(..(.....(.((.((......((((((...(.....)...))))..)).....)).))..)............(............)..............)..)..). Staphylococcus aureus 70S after 50 minutes incubation at 37C; 5S rRNA 7azo 16SA 1512 3.3 RF00177,RF01959,RF01960 URS0000901708_300852 36827973 0003735 0005840 300852 ggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggaucaccuccu ...<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<<<...>>>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<...<<<<<<......>>>>>.>...>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>....<<......>>...>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ ...((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(.((.((..(.....)..)).)).).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((.(((...(((((......)))))....((((....))))..)).)))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((....(..(((.....)))).....)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... 70S thermus thermophilus ribosome with bound antibiotic lead SEQ-977; 16S rRNA 7azo ASIA 76 3.3 RF00005 URS00005AA258_562 36827973 0030533 0006412 562 gcccgganagcucagucgguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>......<<<<.......>>>.>>>>>>>>.... ((...(...(..(.....[..)..).((((.........))))........((..]....))....)...)).... 70S thermus thermophilus ribosome with bound antibiotic lead SEQ-977; Phe-tRNA 7azo PSIA 76 3.3 RF00005 URS00005AA258_562 36827973 0030533 0006412 562 gcccgganagcucagncgguagagcaggggauugaanauccccgunnccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((.........)))).....(((((..]....)))))))))))).... 70S thermus thermophilus ribosome with bound antibiotic lead SEQ-977; Phe-tRNA 7azo ESIA 76 3.3 RF00005 URS00005AA258_562 36827973 0030533 0006412 562 gcccggauagcucagucgguagagcaggggauugaanauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<..........>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((.(........).)).((((.........)))).....(((...........)))))))))).... 70S thermus thermophilus ribosome with bound antibiotic lead SEQ-977; Phe-tRNA 7azo MRNA 30 3.3 URS0002335939_300852 36827973 300852 ggcaaggagguuuuuuuuuuuuuuuuuuuu .............................. .............................. 70S thermus thermophilus ribosome with bound antibiotic lead SEQ-977; RNA (30-MER) 7azo TRNA 73 3.3 RF00005 URS00005AA258_562 36827973 0030533 0006412 562 gcccgganagcucagncggnagagcaggggauugaanauccccguguccuuggnucgauuccgaguccgggca <<<<<<...<<............>>..<<<<<.....>>>>>......<<<<<.......>>>>>.>>>>>>. ((((.((..(..(........)..)(.(.(.........).)..).....(((.......)))..)).)))). 70S thermus thermophilus ribosome with bound antibiotic lead SEQ-977; Phe-tRNA 7azo 23SA 2889 3.3 RF02540,RF02541,RF00002 URS00023359AD_300852 36827973 0003735 0005840 300852 gucaagaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaaacggccgaaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggauguuggagcagccaucauuuaaagagugcguuagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucuugacc <<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<[[<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.....>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...(((....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>.]]...............<<....>>....]].........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....<<..>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<.<..<<<<<......>>>>.>..>.>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<.......>...>>.........<<....>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..((((...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.........<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<.<<..<<<.......<<<<<<<<..>>>>>>>>....>>>............>>.>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<.(((..>>>>..)))>>>>>>.............>>>>..]]>>>>.......<<<<.<<<<<<<<<..<<.......>>>..>>>>>>>..>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))))>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>>. 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70S thermus thermophilus ribosome with bound antibiotic lead SEQ-977; 23S rRNA 7azo 5SA 122 3.3 RF00001 URS000080E212_300852 36827973 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga ..<<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>>> ..(((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).))))))))))) 70S thermus thermophilus ribosome with bound antibiotic lead SEQ-977; 5S rRNA 7azo 16SB 1508 3.3 RF00177,RF01959,RF01960 URS0000901708_300852 36827973 0003735 0005840 300852 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70S thermus thermophilus ribosome with bound antibiotic lead SEQ-977; 16S rRNA 7azo ASIB 76 3.3 RF00005 URS00005AA258_562 36827973 0030533 0006412 562 gcccggauagcucagucgguagagcaggggauugaanauccccguguccuuggnucgauuccgaguccgggcacca .<<<<<.....<<........>>...<<<<<<.....>>>>>>.....<<<<<.......>>>>>.>>>>>..... (..........((........).)..((((.........)))).....(..((.......))..)......).... 70S thermus thermophilus ribosome with bound antibiotic lead SEQ-977; Phe-tRNA 7azo PSIB 76 3.3 RF00005 URS00005AA258_562 36827973 0030533 0006412 562 gcccgganagcucagncgguagagcaggggauugaanauccccgunnccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((.........)))).....(((((..]....)))))))))))).... 70S thermus thermophilus ribosome with bound antibiotic lead SEQ-977; Phe-tRNA 7azo ESIB 76 3.3 RF00005 URS00005AA258_562 36827973 0030533 0006412 562 gcccggauagcucagucgguagagcaggggauugaanauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((............)).(((((.......))))).....(.((.........)).)))))))).... 70S thermus thermophilus ribosome with bound antibiotic lead SEQ-977; Phe-tRNA 7azo MRNB 30 3.3 URS0002335939_300852 36827973 300852 ggcaaggagguuuuuuuuuuuuuuuuuuuu .............................. .............................. 70S thermus thermophilus ribosome with bound antibiotic lead SEQ-977; RNA (30-MER) 7azo 23SB 2873 3.3 RF02540,RF02541,RF00002 URS00023359AD_300852 36827973 0003735 0005840 300852 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70S thermus thermophilus ribosome with bound antibiotic lead SEQ-977; 23S rRNA 7azo 5SB 121 3.3 RF00001 URS000080E212_300852 36827973 0003735 0005840 300852 aucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> .(((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).))))))))))) 70S thermus thermophilus ribosome with bound antibiotic lead SEQ-977; 5S rRNA 7azs 16SA 1511 3.1 RF00177,RF01959,RF01960 URS0000901708_300852 36827973 0003735 0005840 300852 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70S thermus thermophilus ribosome with bound antibiotic lead SEQ-569; 16S rRNA 7azs ASIA 76 3.1 RF00005 URS00005AA258_562 36827973 0030533 0006412 562 gcccgganagcucagucgguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>......<<<<.......>>>>.>>>>>>>.... ((...(...(..(.....[..)..).((((.........)))).....((.((..]....)).)).)...)).... 70S thermus thermophilus ribosome with bound antibiotic lead SEQ-569; Phe-tRNA 7azs PSIA 76 3.1 RF00005 URS00005AA258_562 36827973 0030533 0006412 562 gcccgganagcucagucgguagagcaggggauugaanauccccgunnccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((.........)))).....(((((..]....)))))))))))).... 70S thermus thermophilus ribosome with bound antibiotic lead SEQ-569; Phe-tRNA 7azs ESIA 76 3.1 RF00005 URS00005AA258_562 36827973 0030533 0006412 562 gcccggauagcucagucgguagagcaggggauugaanauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<..........>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((.(........).)).((((.........)))).....(((...........)))))))))).... 70S thermus thermophilus ribosome with bound antibiotic lead SEQ-569; Phe-tRNA 7azs MRNA 30 3.1 URS0002335939_300852 36827973 300852 ggcaaggagguuuuuuuuuuuuuuuuuuuu .............................. .............................. 70S thermus thermophilus ribosome with bound antibiotic lead SEQ-569; mRNA 7azs TRNA 73 3.1 RF00005 URS00005AA258_562 36827973 0030533 0006412 562 gcccgganagcucagucgguagagcaggggauugaanauccccguguccuuggnucgauuccgaguccgggca <<<<<<...<<............>>..<<<<<.....>>>>>......<<<<.........>>>>.>>>>>>. ((((.((..(..(........)..)(.(((.........)))..)...(.(((.......))).))).)))). 70S thermus thermophilus ribosome with bound antibiotic lead SEQ-569; Phe-tRNA 7azs 23SA 2889 3.1 RF02540,RF02541,RF00002 URS00023359AD_300852 36827973 0003735 0005840 300852 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70S thermus thermophilus ribosome with bound antibiotic lead SEQ-569; 23S rRNA 7azs 5SA 122 3.1 RF00001 URS000080E212_300852 36827973 0003735 0005840 300852 aaucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga ..<<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>>> ..(((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).))))))))))) 70S thermus thermophilus ribosome with bound antibiotic lead SEQ-569; 5S rRNA 7azs 16SB 1507 3.1 RF00177,RF01959,RF01960 URS0000901708_300852 36827973 0003735 0005840 300852 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70S thermus thermophilus ribosome with bound antibiotic lead SEQ-569; 16S rRNA 7azs ASIB 76 3.1 RF00005 URS00005AA258_562 36827973 0030533 0006412 562 gcccggauagcucagucgguagagcaggggauugaanauccccguguccuuggnucgauuccgaguccgggcacca .<<<<<.....<<........>>...<<<<<<.....>>>>>>.....<<<<<.......>>>>>.>>>>>..... (...(......((........).)..((((.........))))........((.......)).....)...).... 70S thermus thermophilus ribosome with bound antibiotic lead SEQ-569; Phe-tRNA 7azs PSIB 76 3.1 RF00005 URS00005AA258_562 36827973 0030533 0006412 562 gcccgganagcucagucgguagagcaggggauugaanauccccgunnccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((.........)))).....(((((..]....)))))))))))).... 70S thermus thermophilus ribosome with bound antibiotic lead SEQ-569; Phe-tRNA 7azs ESIB 76 3.1 RF00005 URS00005AA258_562 36827973 0030533 0006412 562 gcccggauagcucagucgguagagcaggggauugaanauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((............)).(((((.......))))).....(.((.........)).)))))))).... 70S thermus thermophilus ribosome with bound antibiotic lead SEQ-569; Phe-tRNA 7azs MRNB 30 3.1 URS0002335939_300852 36827973 300852 ggcaaggagguuuuuuuuuuuuuuuuuuuu .............................. .............................. 70S thermus thermophilus ribosome with bound antibiotic lead SEQ-569; mRNA 7azs 23SB 2875 3.1 RF02540,RF02541,RF00002 URS00023359AD_300852 36827973 0003735 0005840 300852 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70S thermus thermophilus ribosome with bound antibiotic lead SEQ-569; 23S rRNA 7azs 5SB 121 3.1 RF00001 URS000080E212_300852 36827973 0003735 0005840 300852 aucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> .((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......)))..)))))))))) 70S thermus thermophilus ribosome with bound antibiotic lead SEQ-569; 5S rRNA 7azy E 3161 2.877 RF02540,RF02543 URS00023119CC_559292 33990576 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaaaaagacccuguugagcuugacucuaguuugacauugugaagagacauagaggccuuuauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>...{.....<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<.<<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>>..>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]....}.............................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<......<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<.<..>.>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...................>>>.........<........>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<.<<<........>.>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<.......<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<<....>>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>............>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<<........<.....<<<<<...............>>>>><<.<<<<<<<<<<<....>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<...<<.....<<<<....>>>>.....>>.>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>.>>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<<<<<<<<..>>>>>>.>>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((.(((...({((((......)))))[[(...).(((....}]])))....))).))))..))))))))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.(((((......(((((((((((((((((((((((.......(((((((......((((.(....).)))).......))))))).....))))).))))))))))........(((....)))....)))))))).....))))).))))).<((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))....))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((((((((((....((.(((((((.....(((....(((..(.(((....((((((.....))))))..))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((.((.....(..........)....)).....(...(........).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...((((((...((.....)).))))))....[[(((.((...((....(((....)))........((.(.(........)..)))....))....))...(((((........)))))]]((((..((((......((((....)))...(.[[((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...)).......)..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((....)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.((((((((..((((((((((.(((((())))))..))))))))))....((((.....((((..((((........))))..........]]...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......(..(.(.((((((...((.......))...))))))...))...)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)((((....((((....((((((((((}}..)))))..)))))...))))...)))).((((...((((.....}.......))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Context-specific inhibition of eukaryotic translation by macrolide antibiotics; 25S ribosomal RNA 7azy F 121 2.877 RF00001 URS000055688D_559292 33990576 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Context-specific inhibition of eukaryotic translation by macrolide antibiotics; 5S ribosomal RNA 7azy G 158 2.877 RF00002 URS00001BF64E_559292 33990576 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<(.....>>............).>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Context-specific inhibition of eukaryotic translation by macrolide antibiotics; 5.8S ribosomal RNA 7b0y P 36 3.6 URS00021ED8F6_32630 33446560 32630 ccgacagguaaguauuaaccggagagggaacccacu .................................... .................................... Structure of a transcribing RNA polymerase II-U1 snRNP complex; 145-nt RNA 7b0y a 164 3.6 RF00003 URS000032B6B6_9606 33446560 0030627 0000395 0005685 9606 auacuuaccuggcaggggagauaccaugaucacgaaggugguuuucccagggcgaggcuuauccauugcacuccggaugugcugaccccugcgauuuccccaaaugugggaaacucgacugcauaauuugugguagugggggacugcguucgcgcuuuccccug ...........<<<<.<<<<<.<<<<<..........>>>>>>>>>>..<<<...<<<.<<<<<..........>>>>>.>>>...>>>..<<<<<<<<<.......>>>>>>.>>>.>>>>...............<<<<<<..<<<<..>>>>..>>>>>>. ............(((.(((((..((((..........)))).))))).((((...(((.(((((..........))))).)))...))))..(.((((((.......))))))..)..)))................((((((..(((....)))..)))))). Structure of a transcribing RNA polymerase II-U1 snRNP complex; U1 snRNA 7b3b P 10 3.1 URS00021ED945_2697049 33436624 2697049 cuacgcgnug .......... .......... Structure of elongating SARS-CoV-2 RNA-dependent RNA polymerase with Remdesivir at position -3 (structure 1); DNA/RNA (5'-R(P*CP*UP*AP*CP*GP*CP*G)-D(P*(RMP))-R(P*UP*G)-3') 7b3b T 12 3.1 URS00021ED9CA_2697049 33436624 2697049 ugcaucgcguag ............ ............ Structure of elongating SARS-CoV-2 RNA-dependent RNA polymerase with Remdesivir at position -3 (structure 1); RNA (5'-R(P*UP*GP*CP*AP*UP*CP*GP*CP*GP*UP*AP*G)-3') 7b3c P 11 3.4 URS00021ED941_2697049 33436624 2697049 ccuacgcngug ........... ........... Structure of elongating SARS-CoV-2 RNA-dependent RNA polymerase with Remdesivir at position -4 (structure 2); DNA/RNA (5'-R(P*CP*UP*AP*CP*GP*CP*A)-D(P*(RMP))-R(P*GP*UP*G)-3') 7b3c T 12 3.4 URS00021ED994_2697049 33436624 2697049 gcacugcguagg ............ ............ Structure of elongating SARS-CoV-2 RNA-dependent RNA polymerase with Remdesivir at position -4 (structure 2); RNA (5'-R(P*UP*CP*AP*CP*UP*UP*GP*CP*GP*UP*AP*G)-3') 7b3d P 10 2.8 URS00021ED95E_2697049 33436624 2697049 cuacgcagug .......... .......... Structure of elongating SARS-CoV-2 RNA-dependent RNA polymerase with AMP at position -4 (structure 3); RNA (5'-R(P*CP*UP*AP*CP*GP*CP*AP*GP*UP*G)-3') 7b3d T 12 2.8 URS00021ED994_2697049 33436624 2697049 ugcacugcguag ............ ............ Structure of elongating SARS-CoV-2 RNA-dependent RNA polymerase with AMP at position -4 (structure 3); RNA (5'-R(P*UP*GP*CP*AP*CP*UP*GP*CP*GP*UP*AP*G)-3') 7b5k A 2897 2.9 RF02540,RF02541 URS0000A7632D_83333 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<.<....<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>..>>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<.......>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<.........>>>...>>.........<<......>>...>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<......>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.......<<<<<..<<....>>...>>>>>.......>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<..<<.......<<<<<<<<....>>>>>>>>....>>............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>.(<<...<<<<<<<...<<<<<<.......>>>>>>.....<<)..(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......((((.((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))).))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((.......).))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{..((((.(((..(((.........)))..))).....(...((......).)).))))....)))..))))).))...........]]].)...))))))))))...)))))))((((((((......))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...(((.((((((((.((.....))))))))))...)))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((((.((((.(.((.(.........((.((..(.(.......(((.(((....))).)))....).)............)).))).)).).)))).))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). E. coli 70S containing suppressor tRNA in the A-site stabilized by a Negamycin analogue and P-site tRNA-nascent chain.; 23S rRNA 7b5k B 120 2.9 RF00001 URS0000049E57_83333 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). E. coli 70S containing suppressor tRNA in the A-site stabilized by a Negamycin analogue and P-site tRNA-nascent chain.; 5S rRNA 7b5k a 1533 2.9 RF00177,RF01959,RF01960 URS00023119B9_83333 0003735 0005840 83333 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugcccgauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauc ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<......>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>..<<.<<<<<......<.<<<<<<<<.<...>.>>>>>>>>.>........>>>>>....>>.<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((.(((.(......).)))..)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...((((((....))))))....((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... E. coli 70S containing suppressor tRNA in the A-site stabilized by a Negamycin analogue and P-site tRNA-nascent chain.; 16S rRNA 7b5k x 77 2.9 RF00005 URS0001A0F008_83333 0030533 0006412 83333 aggcuuauagcucaggugguuagagcgcaccccugauaagggugaggucggugguucaaguccacucaggccuacca <<<<<<...<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>.>>>>>>.... ((((((...((((.....[...)))).(((((.......))))).....(((((..]....))))).)))))).... E. coli 70S containing suppressor tRNA in the A-site stabilized by a Negamycin analogue and P-site tRNA-nascent chain.; P-site Isoleucine tRNA (77-MER) 7b5k z 76 2.9 RF00005 URS000231199E_83333 0030533 0006412 83333 ggggugguggcucagaagggagagcagcggccuucagagccgcgagacggggguucgauuccccuccgcuccacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... ((.(.((..((((.....[..)))).(((((.......)))))......((((..]....)))).)).).)).... E. coli 70S containing suppressor tRNA in the A-site stabilized by a Negamycin analogue and P-site tRNA-nascent chain.; atRNA synthetic Stop tRNA (76-MER) 7b5k 9 76 2.9 RF00005 URS0000B4C48A_83333 0030533 0006412 83333 gggugauuagcucagcugggagagcaccucccuuacaaggagguggucggcgguucgaucccgucaucacccacca <<<<<<<..<<<<........>>>><<<<<<.......>>>>>>....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).(((...........))).....(..((..]....))..)))))))).... E. coli 70S containing suppressor tRNA in the A-site stabilized by a Negamycin analogue and P-site tRNA-nascent chain.; E-site val tRNA (76-MER) 7b5k 6 11 2.9 83333 guaaucugaac ........... ........... E. coli 70S containing suppressor tRNA in the A-site stabilized by a Negamycin analogue and P-site tRNA-nascent chain.; mRNA 7b7d 2 1771 3.3 RF01960,RF01959,RF00177 URS0001A16A6A_559292 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugagcuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauu ...<<<<<.{.[[[[>>>>><<<<.<<<<<<...<.<...<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<..<<..<<....<<<..................<<....<<.<<<.....>>>.>>.....>>.........<<<<<..<<....>>..>>>>><.<.<<<<<<......(((((((.<<<....>>>....<<......>>>>>>>>.>...>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<<..>>>.>...>>>>>>.........<<<....<<<.....>>>..>>>..>....>.>.....<<<<<<<.<<<<<....>>>>>.>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>>.........<<<[[.....<.<<...<<<.<<....<<<<<<.<<<<<...........>.>>>>.>>>>>>.....<<<<<....................>>>>>....<<<<<.<<.......<<...<.......>..<<<<...>>>>....>>......>>.>>..>>>.........<<...<<<<<<<<.....))))))).>>>>>>>>..>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..]]>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..]]]].}<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<......<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>.......>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<.<<<<.<<<<....>>>>.>>>>.>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>........ ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[[.[[[.(.(....).).....(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(((((((.(.(((....))).).)))).)))....(.((..(...........)..))......)..((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((................))).))))))......((((....................)))).....(((((.((.......((..((.......)).(((.....)))....))......)).))..)))........((....(.((.((......]].]]]]..)).)).)...)..)..))...(((.(((.((...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)).)))..))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].].((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((.(..(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..))))).)..))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).)...(.(..((.(..((((.((..(.((((((((.(((..(.((..(...((((((..(.((.((.(....).)).)).)..))))))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>....... Yeast 80S ribosome bound to eEF3 and A/A- and P/P-tRNAs; 18S rRNA 7b7d LA 3223 3.3 RF02540,RF02543 URS0001A16A8B_559292 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaugguguuuuguauuucacuggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauagaggguguagaauaagugggagcuucggcgccagugaaauaccacuaccuuuauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<.<<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<......>>>..................................<<<<<.<<<<<.........................<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<....<<.<<<<<<<.....<<<....<<<..<.<<<<...<<<<<<.....>>>>>>.>>>>.>..>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>..>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<........>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<.<<<<<<<<<<<....>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.....<<.....<<<<....>>>>.....>>..>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<..<<<.<<.<..........<<<<....<...>.............>>>>..>>>.>>>...>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<.<..<<<<<......>>>>>..>>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((..((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))))....)))).))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.(((((.......(..............)..(((((((((((((((((((((((.......(((((((......(((((((..))))))).......))))))).....))))).))))))))))........(((....)))....)))))))).....))))).))))).<((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))....))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((((((((((....((.(((((((.....(((....(((..(.((((...((((((.....)))))).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((.(((....(.........)....))).....(...(........).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))((((((((((.((......((((.((((....))))))))...)))))))))).)).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....))).........(.(.(........)..).)....))....))...(((((........)))))]]((((..(((.(((...((((....)))...(.[[((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....)))...))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((....)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((((..((.((............(..(..(......)............)..)...)).))...)))))))))....((((.....((((..((((........))))..........]]...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(((.((..)..).)))..)))))...)))....)))).)))))).))))).. Yeast 80S ribosome bound to eEF3 and A/A- and P/P-tRNAs; 25S rRNA 7b7d LB 121 3.3 RF00001 URS000055688D_559292 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Yeast 80S ribosome bound to eEF3 and A/A- and P/P-tRNAs; 5S rRNA 7b7d LC 158 3.3 RF00002 URS00001BF64E_559292 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Yeast 80S ribosome bound to eEF3 and A/A- and P/P-tRNAs; 5.8S rRNA 7b7d Sn 75 3.3 RF00005 URS00021ED942_559292 0030533 0006412 559292 agcgccgugacgcaguggaagcgcgcagggcucauaacccugauguccucggaucgaaaccgagcggcgcuacca <<<<<<<...<<<.......>>>..<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((...(((....[..)))..(((((.......))))).....(((((..]....)))))))))))).... Yeast 80S ribosome bound to eEF3 and A/A- and P/P-tRNAs; tRNA 7b7d Sm 75 3.3 RF00005 URS00021ED942_559292 0030533 0006412 559292 agcgccgugacgcaguggaagcgcgcagggcucauaacccugauguccucggaucgaaaccgagcggcgcuacca <<<<<<<...<<<.......>>>..<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((...(((....[..)))..(((((.......))))).....(((((..]....)))))))))))).... Yeast 80S ribosome bound to eEF3 and A/A- and P/P-tRNAs; tRNA 7b9v 2 196 2.8 RF00004 URS000023C730_4932 33705709 0045131 0000348 0005686 4932 aaucucuuugccuuuuggcuuagaucaaguguaguaucuguucuuguaacaagaccucaaugaggcucuuguuacaauacacauuuuuuggcaccuggacgggaagagacuuuuuauaaagugagacgucgcgacccucgcacuggagucguucuugacuuuuacuuuggucgcuugauguuucucuucccguucg ............................................<<<<<<<<<<<<<<...>>>>.>>>>>>>>>>...................<<<<<<<<<<<..<<<<<....>>>>><<<<<<<<<<<<<<........<<<<<<<....>>>>>>.>.....>>>>>>..>>>>>>>>.>>>>>>>>>>> ............................................((((((((((((((...)))).))))))))))....................((((((((((..(((((....)))))((((((((((((((..........(((((....)))))........))))))..)))))))).)))))))))). Yeast C complex spliceosome at 2.8 Angstrom resolution with Prp18/Slu7 bound; U2 snRNA 7b9v 5 178 2.8 RF00020 URS000053F313_4932 33705709 0000244,0000353 0005682,0046540 4932 aagcagcuuuacagaucaauggcggagggaggucaacaucaagaacugugggccuuuuauugccuauagaacuuauaacgaacaugguucuugccuuuuaccagaaccauccggguguugucuccauagaaacagguaaagcuguccguuacugugggcuugccauauuuuuuggaac ..<<<<<<.<<<<<......<<<<<..<<<<<.<<<<<<<.....<<<<<<<<........>>>>>>>>..............<<<<<<<<...........>>>>>>>>...>>>>>>>>>>>>......<<<<......>>>>>>>>>.>>>>>>>>.>>>............... ..(((((((.((((......(((((..(((((.(((((((.....((((((((........)))))))).........((...((((((((.(.......).)))))))).))))))))))))))......((((......))))))))).)))))))).)))............... Yeast C complex spliceosome at 2.8 Angstrom resolution with Prp18/Slu7 bound; U5 snRNA 7b9v 6 102 2.8 RF00026 URS00006184A9_4932 33705709 0030621 0000244,0000353 0005688,0046540 4932 guucgcgaaguaacccuucguggacauuuggucaauuugaaacaauacagagaugaucagcaguuccccugcauaaggaugaaccguuuuacaaagagauuu <<<<<<<<<<.....>>>>>>>>>>.....................................<<<..<<<.....>>>...>>>.................. ((((((((((.....)))))))))).....................................(((.((((.....)))..)))).................. Yeast C complex spliceosome at 2.8 Angstrom resolution with Prp18/Slu7 bound; U6 snRNA 7b9v E 14 2.8 33705709 4932 agugaucuagaaag .............. .............. Yeast C complex spliceosome at 2.8 Angstrom resolution with Prp18/Slu7 bound; 5' exon of UBC4 mRNA 7b9v I 55 2.8 33705709 4932 guaugucuaaaguuaugugcucuuauuuacuaacaaaaucaacaugcuauugaac ....................................................... ....................................................... Yeast C complex spliceosome at 2.8 Angstrom resolution with Prp18/Slu7 bound; Branched intron and 3' exon of UBC4 pre-mRNA 7bah C 12 1.89 URS000080E329_32630 32630 gacgcuagcguc ............ ............ Structure of RIG-I CTD bound to OH-RNA; RNA (5'-R(*GP*AP*CP*GP*CP*UP*AP*GP*CP*GP*UP*C)-3') 7bah D 12 1.89 URS000080E329_32630 32630 gacgcuagcguc ............ ............ Structure of RIG-I CTD bound to OH-RNA; RNA (5'-R(*GP*AP*CP*GP*CP*UP*AP*GP*CP*GP*UP*C)-3') 7bai C 12 3.4 URS000080E329_32630 32630 nacgcuagcguc ............ ............ Structure of RIG-I CTD (I875A) bound to p-RNA; RNA (5'-R(*(GDP)P*AP*CP*GP*CP*UP*AP*GP*CP*GP*UP*C)-3') 7bai D 12 3.4 URS000080E329_32630 32630 nacgcuagcguc ............ ............ Structure of RIG-I CTD (I875A) bound to p-RNA; RNA (5'-R(*(GDP)P*AP*CP*GP*CP*UP*AP*GP*CP*GP*UP*C)-3') 7bai V 12 3.4 URS000080E329_32630 32630 nacgcuagcguc ............ ............ Structure of RIG-I CTD (I875A) bound to p-RNA; RNA (5'-R(*(GDP)P*AP*CP*GP*CP*UP*AP*GP*CP*GP*UP*C)-3') 7bgd A 32 3.2 93061 acauacaggggguauuaauuugaaaaagaaaa ................................ ................................ Staphylococcus aureus 30S ribosomal subunit in presence of spermidine (body only); mRNA 7bgd a 1096 3.2 RF00177,RF01959,RF01960 URS00021ED94C_93061 0003735 0005840 93061 cuggagaguuugauccuggcucaggaugaacgcuggcggcgugccuaauacaugcaagucgagcgaacggacgagaagcuugcuucucugauguuagcggcggacgggugaguaacacguggauaaccuaccuauaagacugggauaacuucgggaaaccguagcuaauaccggauaauauuuugaaccgcaugguucaaaagugaaagacggucuugcugucacuuauagauggauccgcgcugcauuagcuaguugguaagguaacggcuuaccaaggcaacgaugcauagccgaccugagagggugaucggccacacuggaacugagacacgguccagacuccuacgggaggcagcaguagggaaucuuccgcaaugggcgaaagccugacggagcaacgccgcgugagugaugaaggucuucggaucguaaaacucuguuauuagggaagaacauauguguaaguaacugugcacaucuugacgguaccuaaucagaaagccacggcuaacuacgugccagcagccgcgguaauacguagguggcaagcguuauccggaauuauugggcguaaagcgcgcguaggcgguuuuuuaagucugaugugaaagcccacggcucaaccguggagggucauuggaaacuggaaaacuugagugcagaagaggaaaguggaauuccauguguagcggugaaaugcgcagagauauggaggaacaccaguggcgaaggcgacuuucuggucuguaacugacgcugaugugcgaaagcguggggaucaaacaggauuagauacccugguaguccacgccguaaacgaugagugcuaaguguuaggggguuucccgccccuuagugcugcagcuaacgcauuaagcacuccgccuggggaguacgaccgcaagguugaaacucaaaggaauugacggggaccgucuuguacacaccgcccgucacaccacgagaguuuguaacacccgaagccgguggaguaaccuuuuaggagcuagccgucgaaggugggacaaaugauuggggugaagucguaacaagguagccguaucggaaggugcggcuggaucaccuccuuucu .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<<<......................>>>>.>>>>>......<<........<<<<<<<..<<...<<<<<<<.<<<<.....<<.<<<....>>>.>>......>>>>......<<<<<<<<<<..>>>>>>>>>>......<<<<<<...>>>>>>.>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<<<<<<<........<<.<<................>>.>.>......>>>>>>...>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<<..<<<.<<<<<<<.<<<<<<<<<.......<<<<<<.....>>>>>>.....>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>..>>>>>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<<.....>>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<.>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<..<<<<....<.<<<<..<<<..<<<...>>>.>>>.>>>>.>...>>>>..>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>................ .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((........................))).)))))......(((.......(((((((..((...(((((((.((((.....((.((.(...))).))......)))).....((((((((((....))))))))).)....((((((...)))))).)))))))..))))))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..(.((((((.........(.(....(.......)......))........))))))....).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))...).)))))))..)))))))))..(((.(((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))))..))..))))...))))....((((((....(...((((.........))))...).))))))......{...((((((..((((((((((((.......))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.((((.))))))).))..(.(..((.(.((((.(((...(((((..((((....(.((((..(((..(((...))).))).)))).)...))))..)))))...))).))))..).))...)..)..(((((((((....)))))))))}............... Staphylococcus aureus 30S ribosomal subunit in presence of spermidine (body only); 16S ribosomal RNA 7bhp L5 3644 3.3 RF02543,RF02540 URS0000E60B81_9606 33479117 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcggcccggcggaucuuucccgcgcgggggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucgggggcccccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcgcucuccccccucccggcggggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccgggggaggccacgcgcgcgucccccgagggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcagacccgacccgccacgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaagaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggcaagucgcuaaggagguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagcgggcggcgcgccgcgcccggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcugggucggucgcggccggcgccuagcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacaguuuuuucacugacccggugaggcgggggggcgagccccgaggggcucucgcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccggucccccgccgggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>>..<<<<<<<<<....<<<<<<.<.<.<....<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>>.>>.>>>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<.<...<.<<<<<<<.<<<.....<<<<<<<<<<<..<<..<<<..<..........<<<<.<<<............>>>>>>>.....>..>>>.....>>>>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<<<<<<<<<<<<.<<<<...<<..<<<.<<.<<<<......<<<<<<<....>>>>>>>.......>>>>.>>>>>........>>>>>>...>>>>>>>>>>....................<<<<<<.<<<<<...........>>>>>.<<<<<<.<<<<.<<<<<<<<<<<.<<<<..<<<...<...........>....>>>.>.>>>.>.>>>>>>>.>>>...>>>>..>>>>.>>..<<<<<<<<<<..>>>>>>>>.>>....>>>>>>.....>>>.>>>>>....>>>>...>>>>>>>>..<<<<........>>>><<<<<.....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<........>>>>>>..<<<<<...<<<..<<<.......(((.>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<....................<<<.<<<<<<<<<...<<<....<<<..<.<<<....<<<<........>>>>..>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.........>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<.....................................>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<...........)))...........................................>>>>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>.........>>>>><<<....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<<<<.....>>>>>>>>>>......>>....>>...<<<<<........>>>>>))<<<<....<<<<<..<<<<<<<<....>>>>>>>>..<<<....>>>......<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>.............>>.>>>.>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<...............>>>>><<.<<<<<<<<<<<.......................>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>>.<<<<.........>>>>.........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>...>>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<.......>>>>>>>...<<<<<.....<<<<........<<......>>...................<<<<<<<<<<.......>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>><<<<....>>>>>>)))].....<<<<<<<..<<<..)))))).>>>>>>>>>>.........>>>>..>>>>>>.......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<....<<<<<.................>>>>>..<<<<....<<<<...<<<.<<<<<<<]]].>>>>>..>>.>>>..>>>>...>>>><<<<....<<<<<...........>>>>>....>>>>.>>>...>.>>>>>>.....<<<<<<<.<<..<<<<....<<<........<<<<<.<<<<....>>>>.>>>>>.......>>>...<<<...<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>...>>>..............>>>>..>>>>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<....<<<<<......>>>>>...>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((...((((((((((.....)))))).)))).....)))....(((((((((....((((((.(........((((((((..({((((......)))))....[[(...).(((....}]])))...).)))))))...).))))))...)))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((....(((((((.(((.(...(((((((((((..((.(.((.((.(..(.....((((.((..............)))))).).).).))).)....)))))))))))))...)..))).))).))))....((((((((((((.((((((((((...((..(((..(.((((......(((((((....))))))).......))))..))))........))))))..)))))).))))....................((((((.(((..(.........)..))).((((((..(((.((((((((((..(((....((....................))....)))...))))))).)))...)))...)))).)).....(((.(((..))).)))........)))))).....))).)))))...)))))...)))))))).[(..(........)..)((((......(((((((((((((..(((..(((((........))))..)..)))...((....))...(((((..........)))))..(((((...(((..(((..........[)))..)))....))))).(((((((((.((((......))))))))))).))....)))))))))))))..((.....((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((........)))).)))..).))))))))).(.((.......))...)..))))))........))..((((((....(.(((....))).)((.(((((((....................(((.((((((((....(((....(((..(.(((..(.(((..(....)..)))).))).)..)))..)).)....))))))...(((((((((.(......))))))))))....))))))))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.....{....((...................................))......)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((..........]..............................................)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).......))))((.....((.....((((((.......)))))).(((.....((((..((..(((((((...((.....)).))))))....[[(((.((...((....(((....)))..........((.((((....(...)....))))))......))....))...(((((........)))))]]((((....(((((...((.((((....)))).))..((((....)))...(...((((((...(((((((((((((((((((((((..{{{..))))))....((((..((((.((((.....(((.....))).....))))))))...)))).....(((((((.......))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).))).))).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((.......................)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((..((..((((.(.(..(((.....((((....)))).....))))).))..)))).(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.(.(((((((.((((((((.....))))))))...(((((.....((((.....(..............)................((((((((((.......))))))))))..))))..)))))....))))))).)..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......(....(.((((((...((.......))...))))))...)....)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))....))..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}}.)))))..)).))...))))...)))).(((....((((.....}.......))))....)))..)))...).)))))).....(((((((.((..((((.(..(((........(((((.((((....)))).))))).......)))...(((...(((....((.(.(((.(((......))).)))).))...)))...)))...........)..))))..)))))))))(((((.(..(.......)..)....((.(((((((.((.....((((.(..(((((......)))))..)))))....))....)))).))).))..))))).. Cryo-EM structure of the human Ebp1 - 80S ribosome; 28S ribosomal RNA 7bhp L7 120 3.3 RF00001 URS000002B0D5_9606 33479117 0003735 0005840 9606 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. Cryo-EM structure of the human Ebp1 - 80S ribosome; 5S ribosomal RNA 7bhp L8 156 3.3 RF00002 URS00004B2C76_9606 33479117 0003735 0005840 9606 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<.<<.....>>>.....(.<<<......>>.............>>>..)...>>>....<<....>><<<<<<<<<.....>>>>>>>>>.................... .........................................((((((.[[....[)))...].(.(((......]].............)))..)...)))....((....))(((((((((.....))))))))).................... Cryo-EM structure of the human Ebp1 - 80S ribosome; 5.8S ribosomal RNA 7bkp Z 14 2.8 URS0000E60BDD_10879 34795277 10879 cucuccucggcuug .............. .............. CryoEM structure of disease related M854K MDA5-dsRNA filament in complex with ATP; RNA (5'-R(P*CP*UP*CP*UP*CP*CP*UP*CP*GP*GP*CP*UP*UP*G)-3') 7bkp X 14 2.8 URS0000E60BBD_10879 34795277 10879 caagccgaggagag .............. .............. CryoEM structure of disease related M854K MDA5-dsRNA filament in complex with ATP; RNA (5'-R(P*CP*AP*AP*GP*CP*CP*GP*AP*GP*GP*AP*GP*AP*G)-3') 7bkq X 15 3.4 URS0000E60B84_10879 34795277 10879 uccaugcgcaugacg ............... ............... CryoEM structure of MDA5-dsRNA filament in complex with ADP with 92-degree helical twist; RNA (5'-R(P*UP*CP*CP*AP*UP*GP*CP*GP*CP*AP*UP*GP*AP*CP*G)-3') 7bkq Y 15 3.4 URS0000E60BC3_10879 34795277 10879 cgucaugcgcaugga ............... ............... CryoEM structure of MDA5-dsRNA filament in complex with ADP with 92-degree helical twist; RNA (5'-R(P*CP*GP*UP*CP*AP*UP*GP*CP*GP*CP*AP*UP*GP*GP*A)-3') 7bl2 A 2902 3.7 RF02540,RF02541 URS00023119D2_83333 33639093 0003735 0005840 83333 guuguaagguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccuuacaacgcc <<<<<<<<<<<<<<<......<<<<<<<<<<<....<<<..<<<<<<<<<<<<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..>>>......>>.>>>>>>>.>>...............<<....>>....>>.........<<<<.....>>>>.............>....>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<.>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<.........>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<..<......>..>>>>>....>>>>>><<<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>.>>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<....<<..>>.....>>>>><<<<<......<<<...<<<<.....>>>>...>>>....>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<<.<<....>>..>>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.<<.....<<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..>>>>..>>>>>>>>>.............>>>>..>>>>>>>............<<<<<<<...<<.......>>...>>>>>>>....<<<<<.<.<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>...>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>>>>>>>>... (((((((((((((((......((((((((((.....(((..(((((((((((((......((((((....[[[.))).....((((((...((.]]].....)).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....(((((((...[.......)))))))......((.((].[[[[)).))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..))))...(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.((.......))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((....((.(((....((.((...))..))....))).))...)).).....)))))).)))..)))))))).)....(((((((.(......).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(..((..(((.....{.(((((..(.....................).........(((......)))..)))))...)))..))..).))...........]]].)...))))))))))...)))))))(((((............)))))....))))))((.((((...(((.......(((((((....)))))))....)))..))))..)).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((...(((...(((....)))...)))...)))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(.(((..)])).)...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(.(((.........))).)........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).[..(((((......].)))))..((((((((.(((.((.....(((((.((((((..(((((.(((.(((((.(((((((((((..(((.(.........(((((..(((........((((.(....).)))).....)))............)))))).)))..)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((.......)))((((((...........))))))(.((...(((((((...(((((.........))))).....((.[.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....((((((..((..]]]]..)).)))))).....)}......))))..)))))))...........(.((((((...((.......))...))))))...)..((((.((((((..((((((((........)))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).((((....((((...(((((((((((}}}.))))))..)))))...))))..))))...(((....(.((.....}.......)).)....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))))))))))... pre-50S-ObgE particle state 1; 23S ribosomal RNA 7bl2 B 119 3.7 RF00001 URS0000049E57_83333 33639093 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca .<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. ((((((((.(.....((((((((....((((((...............)))..)))...)))))).)).((.......((((((((...)))))))).......))...).)))))))) pre-50S-ObgE particle state 1; 5S ribosomal RNA 7bl3 A 2902 3.5 RF02540,RF02541 URS00023119D2_83333 33639093 0003735 0005840 83333 guuguaagguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccuuacaacgcc <<<<<<<<<<<<<<<......<<<<<<<<<<<....<<<..<<<<<<<<<<<<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..>>>......>>.>>>>>>>.>>...............<<....>>....>>.........<<<<.....>>>>.............>....>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>...>.>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<.>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<.........>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<..<<....>>..>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<....<<..>>.....>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<<.<<....>>..>>>>>>........>>>>>>>>..>>>>>.<<<<<.......>>>>>.........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.<<.....<<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<.......>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..>>>>..>>>>>>>>>.............>>>>..>>>>>>>.............<<<<<<...<<.......>>...>>>>>>.....<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>>>>>>>>... (((((((((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((.(((...(((]]]..].))).......))).))...)))....(((....)))(((((.(....).))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).)..........(....)....(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((.((((...[.......)))).))......((.((].[[[[)).))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..))))...(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((((((.)))).))...)))).)))..)).).....)))))).)))..)))))))).)...((((.(((.(......).))).))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((......(.............)..........(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((..((....))..)))))....))))))(..((((...(((.......(((((((....)))))))....)))..))))...).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..(((((.((((((...{{{.).))))).((..((((...(((((.((((((.((.....)))))))).)..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((.(.....).))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((.(((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(.(.(.........).).)........((..........(((((.......)))))..)..)....))))...)).).))))).)..))).)))))))).)))))).....)).[..(((((......].)))))..((((((((.(((.((.....(((((.((((((..(((((.(((.(((((.(((((((((((.((((...........(((((..(((.......(((((((....)))))))....)))............)))))..)))).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((.......)))((((((...........))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..)))))))...........(.((((((...((.......))...))))))...)..((((.((((((..((((((((........)))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....(.((.....}.......)).)....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))))))))))... pre-50S-ObgE particle state 2; 23S ribosomal RNA 7bl3 B 119 3.5 RF00001 URS000080E133_83333 33639093 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca .<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))) pre-50S-ObgE particle state 2; 5S ribosomal RNA 7bl4 A 2897 2.4 RF02540,RF02541 URS00004B0F34_83333 33639093 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<.>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<..<<....>>..>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<<..>>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<<.<<....>>..>>>>>>.>.....>>>>>>>>>..>>>>>.<<<<<.......>>>>>.........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<..<<<......<...<<<<....>>>>...>...>>>............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((..((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))))))..)))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((.(((.)))..))...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{..((((.(....(((.........)))....).....(..(((......)))).))))....)))..))))).))...........]]].)...))))))))))...)))))))((((((.((....)).))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((...(((...(((....)))...)))...)))..(((((........)))))]](((((((((((((...((((....((((..(((..(((((.((((((...{{{.).))))).((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((....(((....])))....)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))..(((.........)))..........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((.(((.((((.(.........(((((...((..........((.(....).)).......)).............)))))).)))).))).)))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). in vitro reconstituted 50S-ObgE-GMPPNP-RsfS particle; 23S ribosomal RNA 7bl4 B 119 2.4 RF00001 URS000080E133_83333 33639093 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca .<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))) in vitro reconstituted 50S-ObgE-GMPPNP-RsfS particle; 5S ribosomal RNA 7bl5 B 119 3.3 RF00001 URS0000049E57_511145 33639093 0003735 0005840 511145 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca .<<<<<<<<<.....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. ((((((((((.....((((((((....(((.......................)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))) pre-50S-ObgE particle; 5S ribosomal RNA 7bl5 A 2913 3.3 RF02540,RF02541 URS00023119D2_511145 33639093 0003735 0005840 511145 guuguaagguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccuuacaacgcc <<<<<<<<<<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<.>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<......<<<<.......>>>>.............<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<.<<....>>.>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<<.<<....>>..>>>>>>..>.....>>>>>>>>..>>>>><<<<<.........>>>>>.....................<.<<<.....>>>.>...........>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<...<<......<<<<<<<<....>>>>>>>>...>>.............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<....<<<<<...<<.......>>...>>>>>.....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>>>>>>>>... (((((((((((((((......((((((((((.....(((..((((((((.((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((.(((((..[......))))).))......((.((].[[[[)).))..)))......))..)))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((.(......).))))...)[)))...(((.(((((........))))))))..).))))))))).(.((.......))...)..))))))......).))..((((((....(((((....)))))..(((((((..((((((((((.....(((...(((.((((...((((((.)))).))...)))).)))..)).).....)))))).)))..)))))))).....((((((((.(......).))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.......((.........))...........(...((......)).).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((.(.((....)).).))))....))))))(.(((((...(((......((.(((((....))))).))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((.(((((((((...((((....((((..(((..(((((.((((((...{{{.).))))).((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))).))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((....((((..)])))....)))...))))))(...).......(((((.(((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(.((...........)).)....................(..((.......))...).........))))...)).).))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((..(...(.........(((((....(........(.((.(....).)).).....)..............))))))...)..)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..((((.....))))((((((...........))))))([((....((((((....((((.........))))......((][.[[[))....))))))....((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..)))))).......(..(.(...((((...(.........)...)))).....))...).......(((((.((((((..((((((.((......)).)))..))).(((((.....))))).....)))))..)...))).))....((.((((....))).).))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....(.((.....}.......)).)....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))))))))))... pre-50S-ObgE particle; 23S ribosomal RNA 7bl6 A 2897 4.0 RF02540,RF02541 URS00004B0F34_83333 33639093 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<.>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<..<<....>>..>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<....<<..>>.....>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<<.<<....>>..>>>>>>........>>>>>>>>..>>>>>.<<<<<.......>>>>>.........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<..<<<......<...<<<<....>>>>...>...>>>............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((.((((..(((]]]..].)))......)))).))...)))....(((....)))((((((......)))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((..((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))))))..)))...))))...)....((.((((...[.......)))).))......((.((].[[[[)).))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..))))...(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..(.((.....)).).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.((.......))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((.(((.)))..))...)))).)))..)).).....)))))).)))..)))))))).)...((((.(((((......))))).))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{..((((.(....(((.........)))....).....(..(((......)))).))))....)))..))))).))...........]]].)...))))))))))...)))))))((((((.((....)).))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..(((((.((((((...{{{.).))))).((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((.(((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........((.((..((....))...)).))........))))))))..)))))..(((.........)))..........((..........(((((.......)))))..)..)....))))...)).).))))).)..))).)))))))).)))))).....)).[..(((((......].)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((.(.((((.(.........(((((...((..........((.(....).)).......)).............)))))).)))).).)))))))))...(((..(((((.....))))).)))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..)))))).......((((.(.(((((.(..((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(.(((((.....(....)....))))).).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....(.((.....}.......)).)....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). 50S-ObgE-GMPPNP particle; 23S ribosomal RNA 7bl6 B 119 4.0 RF00001 URS000080E133_83333 33639093 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca .<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))) 50S-ObgE-GMPPNP particle; 5S ribosomal RNA 7bt6 1 2962 3.12 RF02540,RF02543 URS000061F377_559292 33037216 0003735 0005840 559292 guuugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaaacuuuaaauauguaagaaguccuuguuugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuuccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauaguuucuuuacuuauucaagacauugucagguggggaguuugggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggagugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ..........................<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<..<<<<<..<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>......>>>>>.>>>>>........<<<<<<<.<....>.>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<<.....<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<....<....>....>>>>.>>.>>....>>>>>>.>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>.><<.<<.<......<<<.<<<<<<<.......................>>>>>...<<<<..<<....>>..>>>>.....>>>>>.....>.>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>..>.....>>>>>><<<....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>.......>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<..>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...............<<.............<<<<....>>>>..........>>...........<<.........>>.............<<..>>......>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>...>>>....<<<<<....>>>>>....[[[[[..{{{........((((((..[[[[..<<<<<..<<.<.<<..<<<<<.............>>>>>...<...>.....>>.>.>>...>>>>>......<.<..<<<<<<<<...........>>>>>>>>.....<<<<<<<...<<<<<<.......>>>>>>.....<<......>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>...>.>...[...(((((...((((.>>>>>>)))).)))))....].....]]]]...))))))..............<<<<<...<<.......>>...>>>>>.................<<<<<...<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>.....>>>>>.....<<<<<<<....>>>.>>>>........}}}.]]]]]....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<....<<<<<<<<<.}}}..>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<.....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>..............>.>>>.>>>>>>..<<<<<<<.............>.....<<<<<<<<<.<<<....<<<<.<..<<<<<......>>>>>..>>>>>...>>>....>>>>.>>>>>.>>>>>>.. ..........................(((((......((....)).......)))).).........((....))...((((......((.....)).....))))...((((.........(((.((.(((...))).)).))....)............(..(((((.(.(((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))).).....)))))..)......)....(.(((((.(....).))))).).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((......((((.(....).)))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).)))))..((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).(((((.((....(....)....))..))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...((((.(..(..........).)))))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((...(.......(((.(((((((.(.......(.....).....).)))))....(((...(....)...)))......)))))......)...))...(((.((.((.....)).)).))).....(((......)))...(((((((...((([[[...(.(((((.......(...........((.((((((((((.....{.(((((.(.(...((.........))...).).....(...((......)).).)))))...))))))))))))...........]]].).....)))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....((......)).......))....))...(((((........)))))]]((((.((((.(.(...((((....))).......((((((...((((.((((((((((((((((((..{{{..))))))(...((((.....(((((.....(((.....))).....)))))......))))....)((((((........)))))))))).).))))))).))))(...)....))))))....)....).)...)))))))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((..)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....(((.......)))......))))))).}..............(.............((((....))))..........)............((.........))..............(..).......)).))))))).)..))).)))))))..))))))....)).[..(((((..].)))))....(((((..(((........(((((....(((..((.(............(.....(........)......)........................).))........(.....(((((...........)))))........(((((((...((((((.......))))))...................)))))))...(((....(.........)....)))((((....))).).).....(...((.((...((((.]]]]]])))).)).).)...).....))).....)))))...............((((...((.......))...))))...................(((...(((((..(.(((((((......))))))..).).(.(.(.....).).).....))))).....)))......(((.(((....)))..)))........))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}}.)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......(.((((.(((.......((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).))))))................))).)))).)..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Cryo-EM structure of pre-60S ribosome from Saccharomyces cerevisiae rpl4delta63-87 strain at 3.12 Angstroms resolution(state R1); RDN25-1 rRNA 7bt6 2 158 3.12 RF00002 URS00001BF64E_559292 33037216 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Cryo-EM structure of pre-60S ribosome from Saccharomyces cerevisiae rpl4delta63-87 strain at 3.12 Angstroms resolution(state R1); RDN5.8-1 rRNA 7bt6 3 121 3.12 RF00001 URS000055688D_559292 33037216 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<.....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<...<......>..>>>>.....>>>>>>.>>>>>>>>. ((((((((.....((((((((.....(.((((...(....)...))).)....)...)))))).))((((((.......(...................).....)))))).)))))))). Cryo-EM structure of pre-60S ribosome from Saccharomyces cerevisiae rpl4delta63-87 strain at 3.12 Angstroms resolution(state R1); RDN5-2 rRNA 7btb 1 3058 3.22 RF02540,RF02543 URS000061F377_559292 33037216 0003735 0005840 559292 guuugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaaacuuuaaauauguaagaaguccuuguuugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuugggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggagugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ..........................<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<<.<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<......<<<<<<<<<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>....>>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<......>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<......<<<....>>>..<<<<..<......<<<.<<<<<<<......<.........>......>>>>>...<<<<..<<....>>..>>>>.....>>>>>.....>.>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<<....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<...<.<<<....>>>.......<<<<<<...<<<<.<<<<<<<<<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>.>.>>>>>>>.>>>>.........>>>>>>.....>....>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<.....<..>......>>>>><<.<<<<<<<<<<<..>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>.......<<.....<<<<.....<<.....<<<<....>>>>.....>>..>>>>.....>><<<.<..........>.>>>.........<<..>>......>>.>>>>>>>.....>>.>>>>>>>..>>>>>>...>>>....<<<<<....>>>>>....[[[[[..{{{........((((((.{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<.....>>>>>>>>>...<<<<<.....<<..<.....<......>...................<<<<<<....>>>>>>..>.>>..>>>>>.....>>>>>>>>..>>>>>......<..<.....<<<<...........>>>>.........<<<<<<<...<<<<<<.......>>>>>>...................>>>>>>>...<<<..<<<<.......>>>>..>>><<<<....>>>.>.>.>..[....(((((...((((.>>>>>>)))).)))))......]...]]]]..}))))))..............<<<<<...<<.......>>...>>>>>...................<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>>...>>>.......<<<<<<<....>>>.>>>>........}}}.]]]]]....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<.....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>..............>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<........>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ..........................(((((......((....)).......)))).).........((....))...((((......((.....)).....))))...((((.........(((.((((((...)))))).))....)........((((((..((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))))....)))).))))))...)....(.(((((........))))).).....(((((...[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.(((((......(((((((((((((((((((((((.......(((((((......((((((....)))))).......))))))).....))))).))))))))))........(((....)))....)))))))).....))))).)))))..((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).(((((.((....(....)....))..))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)<)))...(((...(.((........)))..)))....))))))))).(.((.......))...)..))))))......).))).((((((......(((....)))..((.(.(.......(((.((((((.........................))))...((((..((....))..)))).....)))))......).).))...(((.((.((.....)).)).))).....(((......)))...(((((((...((([[[...(.(((((.......(...........((.((((((((((.....{.(((((.(.(...((.........))...).).....(...((......)).).)))))...))))))))))))...........]]].).....)))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........((((((........))))))....))....))...(((((........)))))]]((((..(((((((...((((....)))...(.[.((((((...((((.(((((((((((((((((...{{{...)))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.((((((((((.(.)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....(((.......)))......))))))).].............(.(.....((.....((((....)))).....))..).)......................................(..).......)).))))))).)..))).)))))))..))))))....)).[..(((((..].)))))....(((((..(((........(((((..(.(((..(((((.(.(.((((..(((((((((.....)))))))))....((((.....((..(............................]...((((((....))))))..).))..))))......)))).).)..)))))......(.((.....((...............)).........(((((((...((((((.......))))))...................)))))))...(((....(.........)....)))((((....))).).))).......(((.(...((((.]]]]].)))).).)).).........)))...).)))))...............((((...((.......))...))))...................((((.((((((..(.(((((((......))))))..).).(.(.(.....).).).....))))))...))))......(((.(((....)))..)))........))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}}.)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......((((((.(((.......((.(........(((((((..).)))))).....))).......((.(((...(((((.(..(((......)))..).))))).))).))................))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(((..(..)....)))..)))))...)))....)))).)))))).))))).. Cryo-EM structure of pre-60S ribosome from Saccharomyces cerevisiae rpl4delta63-87 strain at 3.22 Angstroms resolution(state R2); RDN25-1 rRNA 7btb 2 158 3.22 RF00002 URS00001BF64E_559292 33037216 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Cryo-EM structure of pre-60S ribosome from Saccharomyces cerevisiae rpl4delta63-87 strain at 3.22 Angstroms resolution(state R2); RDN5.8-1 rRNA 7btb 6 65 3.22 URS000013305B_559292 33037216 559292 ccuucucaaacauucuguuugguagugagugauacucuuuggaguuaacuugaaauugccuuaaa ......<<<<<<...>>>>>>.....<<<<.<.<<<<....>>>>>.>>>>.............. .......(.((.....)).)......((((...((((....))))..)))).............. Cryo-EM structure of pre-60S ribosome from Saccharomyces cerevisiae rpl4delta63-87 strain at 3.22 Angstroms resolution(state R2); ITS2-1 miscRNA 7bv2 P 11 2.5 URS0001A16A67_2697049 32358203 2697049 gauuaaguuau ........... ........... The nsp12-nsp7-nsp8 complex bound to the template-primer RNA and triphosphate form of Remdesivir(RTP); Primer 7bv2 T 14 2.5 URS0001A16A6F_2697049 32358203 2697049 uuuauaacuuaauc .............. .............. The nsp12-nsp7-nsp8 complex bound to the template-primer RNA and triphosphate form of Remdesivir(RTP); Templete 7bv8 A 2897 3.14 RF02540,RF02541 URS0000B21DE5_83333 32571953 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaaccauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<......>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<..................................<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<......>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<<.<<....>>..>>>>>>........>>>>>>>>..>>>>><<<<<.........>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<.....<<<<............<<<...<<.......<<<<<<<<....>>>>>>>>....>>.............>>>..>.>>>.....>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>.(<<...<<<<<<<...<<<<<<.......>>>>>>.....<<)..(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.........<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.......<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......((((..(.(.(((.(((...(((.(......).)))[[(...).(((.....]])))...)))...))).).)..))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((.(......).))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((....((((((((.....(((...(((.(((....((..(...).)..)....))).)))..)).).....)))))).))....))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.......(((.(.(........................)........((......))...).)))...)))..))))).))...........]]].)...))))))))))...)))))))((((.(((......))).))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..(((((.((((((...{{..).))))).((..((((...(((.(.((((((.((.....)))))))).)...)))..[))))...))(...(...........)...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(.((...........)).)........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((((..(......(.(..........((....(((........(..............).....)))..............)).))........).))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....((.((((.((..]]]]..)))))).)).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))...)....(((((((....))).))))..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))..)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Mature 50S ribosomal subunit from RrmJ knock out E.coli strain; 23S rRNA 7bv8 B 120 3.14 RF00001 URS0000049E57_83333 32571953 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Mature 50S ribosomal subunit from RrmJ knock out E.coli strain; 5S rRNA 7bzf F 10 3.26 URS0001A24B66_12110 32526208 12110 cugugucguc .......... .......... COVID-19 RNA-dependent RNA polymerase post-translocated catalytic complex; RNA (31-MER) 7c2k F 20 2.93 URS0001A24B73_12110 32526208 12110 gggagcuccuccugugucgu ..<<..>>............ ..((()))............ COVID-19 RNA-dependent RNA polymerase pre-translocated catalytic complex; RNA (29-MER) 7c2k G 12 2.93 URS0001A24B74_12110 32526208 12110 acgacacaggng ............ ............ COVID-19 RNA-dependent RNA polymerase pre-translocated catalytic complex; RNA (5'-R(*UP*GP*UP*UP*CP*GP*AP*CP*GP*AP*CP*AP*CP*AP*GP*G*(F86)P*G)-3') 7c7a A 330 2.8 RF00030 URS0001A24B54_559292 32586950 3.1.-.- 0000171 0006364 0000172 559292 aauccaugaccaaagaaucgucacaaaucgaagcuuacaaaauggaguaaaauuuuguuuacucaguaauaugcuuuggguugaaagucucccaccaauucguaugcggaaaacguaaugagauuuaaaaaaauuguuuaaaucaacucauuaaggaggaugcccuuggguauucugcuucuugaccugguaccucuauugcaggguacugguguuuucuucgguacuggauuccguuuguauggaaucuaaaccauaguuaugacgauugcucuuucccgugcuggaucgaguaacccaauggagcuuacuauucuugguccauggauu <<<<<<<<<<<<<<.<<<<<<<......<<<<<<..........<<<<<<<......>>>>>>>........>>>>>>........[.((((.<<<.........<<<.....>>><<<<<..........................>>>>><<<.<<<<<<<<....>>>>>>>>.>>>......<<<<<<<<<........>>>>>>>>>..........>>>...<<<<<<<<......>>>>>>>>.............>>>>>>><<<<..<<<......>>>..>>>>........)))).]...>....>>>>>>.>>>>>>> ((((((((((((((((((((((......(.((((..........(((((.(.......))))))........)))).).{.....[..[[[[.(((.(.......(((.....)))((((((........................)))))).((.((.((.((....)).)).)).))..)..(((..(((((..........)))))..).).)......)))...((((((((......)))))))).............))))))).(((..(((......)))..)))...}.....]]]].]..))....)))))).))))))) Cryo-EM structure of yeast Ribonuclease MRP with substrate ITS1; Ribonuclease MRP RNA subunit NME1 7cpj a 1539 3.3 RF00177,RF01959,RF01960 URS000080DDC0_562 34906996 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccnunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<..<....>..>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<.......>>...>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((............))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((.(((..((....)))).))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((....((((....))))..)))).)).))))))..(((.......((((....))))......)))..((.(((((...(....(((.((((.......)))).))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.(((((((((.......((((((.....)))))).....)))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((.((((((((.....)))))))).)))...((..]])).....)))))))))).(((......((((....))))....)))...]]].]((((..(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...((.(((....))).)).....(....)...))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...))))))).)).))..(.(..((.(.((((.(((...(((((((((((....((((((.((((..((....)).))))))))))...)))))))))))...))).))))..).))...)..)..(((((((((....)))))))))}........... ycbZ-stalled 70S ribosome; 16S ribosomal RNA 7cpj A 2900 3.3 RF02540,RF02541 URS0000A76322_562 34906996 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccgggagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<<..>>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<.<<..>>.>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<.<.......<<.........>>..............<<<......>>>..>.>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<..........>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<......>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<<.<<....>>..>>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<.............<<<...<<..........<<<<......>>>>.......>>.............>>>....>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......((((.((((((((.(((...(((((......)))))[[......(((.....]])))...)))...)))))))).))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((.(((.((((...((((.(......).))))...)[)))...(((.(((((........))))))))..).)).)))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))..(((((((..((((((((((.....(((...(((.((((...(...(((..)))....)...)))).)))..)).).....)))))).)))..)))))))).....(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((.(.......(............).............(((......)))..).)))...)))..))))).))...........]]].)...))))))))))...)))))))((((((..........))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((........)))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((..((..................(..............(.((......)).).....................).........).).)))))))))...(((..(((((.....))))).)))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....((.((((.((..]]]]..)))))).)).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).).....((.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..))....(..((((....))).)..)....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). ycbZ-stalled 70S ribosome; 23S ribosomal RNA 7cpj B 120 3.3 RF00001 URS00008116C5_562 34906996 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. .(((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((.(((((...))))).)).......))...))))))))).. ycbZ-stalled 70S ribosome; 5S ribosomal RNA 7cpj 9 77 3.3 RF00005 URS00001DEEBE_562 34906996 0030533 0006412 562 cggugauuggcgcagccugguagcgcacuucguucgggacgaaggggucggagguucgaauccucuaucaccgacca <<<<<<<..<<<<.........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((......[..)))).(((((.......)))))......((((..]....)))).))))))).... ycbZ-stalled 70S ribosome; P/P tRNA 7cpu L5 3539 2.82 RF02543,RF02540 URS00023119F6_10090 36517592 0003735 0005840 10090 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccgcgcgucgcggcgugggaaauguggcguacggaagacccacuccccgggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggccccggcgcgccgggcucgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggccggccgugcccggggcggaucugcgggggaccgucccccggccggcgaccggccgccgccgggcgcacuuccaccguggcggugcgccgcgaccggcuccgggacggccgggaaggcccgguggggaagguggcucgggcccgaguguuacagcccuccggccgcgcuuucgccgaaucccggggccgaggaagcgucgccgcgcucucccucgggggccgggccgccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcguggucgcgccgucggguccgggggcggucacgcgugagcgcacggggucggcggcgaugucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacgcgugcgcgagucaggggcucguccgaaagccgccguggcgcaaugaaggugaagggccccgcccgggggcccgaggugggaucccgaggccucuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcguacgcguuaggacccgaaagauggugaacuaugcuugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgccgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcaguggaacgggacgggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagugccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcugggucggccggcgccuagcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacaugcucaucguuuuuucacugacccggugaggcgggggggcgagccccgaggggcucucgcuucuggcgccaagcguccgucccgggcgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgaaggagccucgguuggccccggauagccggguccccgccgggguccggugcggagagccguucgucuugggaaacggggugcggccggaaaggcggccgcccucucgcccgucacguugaacgcacguucguguggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<...<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>...<<<<<<<<<....<<<<..<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>.......>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<<<<<<<<<<..<..<<<<<<<.<<<.....>>>>>>>>>>..>..>>>>...>>>>>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<.<<<<<<<<<<<<<<<...<<.<<<<.<<.<<<<......<<<<<<..>>>>>>.......>>>>>>>>>>......>>>>>>..>>>>>>>>>>>.............<<<<<<.<<<<..>>>>.<<<<<<<<<<<.<<<<<<<<<<<..<<<<.<<<<<<<...........>.>>>>>>.>>>>...>.>>>>>>>.>>>...>>>>.>>>>>.>>...>>>>>>......>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<.....>>>>>>>..<<<<<...<<<..<<<...[[...(((>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<.....<<<.<<<<<<<<<...<<<....<<<..<.<<<<...<<.............>>.>>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.........>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<.<...................................................>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<...)))...]]......................>>>>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<...........>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<..<<<.<.<...>..>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<...............>>>>><<.<<<<<<<<<<<.................>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<<<.<<....>>..>>>>>>>>>...<<<<<.....<<<<.....................................<<<<<<<<<..>.>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>><<<<....>>>>>>)))].....<<<<<<<..<<<..)))))).>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<...<<<.<<<<<<<]]].>>>>>..>>.>>>..>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.....<<<<<<...<<..<<.<....<<<........<<<<<<<<<<....>>>>>>>>>>.......>>>...<<<..<<<<....<<<<....<<<<......>>>>...>>>>...>>>>..>>>................>.>>..>>.>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<....<<<<<......>>>>>...>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((...((((((((.(.....).)))).)))).....)))....(((((((((....(((...(((((((..({((((......)))))....[[(...).(((....}]])))...).))))))........)))...)))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....((((((((((((((((((..(..(((.(((.((.......))))).)))..)..))))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((.((((.((.((((......(.((((..)))).).......))))))))))......))))))..))))))))))).............((((((.(((.(.)))).(((((((.(((.((((((((((...((((...(((................)))...)))).....))))))).)))...)))..))))).))...)))))).....))).)))))...)))))...)))))))).[((((........))))((((((..(.(((((((((((((..(((..(((((........))))..)..)))...((....))...(((((((.....)))))))..(((((...(((..(((....[...[[[)))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((.(((((.((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))..).)))).)))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((.(((((((.....(((.((((((((....(((....(((..(.(((.......................))).)..)))..)).)....))))))...(((((((((.(......))))))))))....))))))))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.....{........(....................)................................)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((...]]]...]..........(...)........)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...((....(((....)))...(.)....((.((((.............))))))......))....))...(((((........)))))]]((((....(((((...((.(.......).))..((((....)))...(...((((((...(((((((((((((((((((((((..{{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....(((((((.......))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((.................)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.(.......((((.((((((..(((((.(((((((((.(((((.((...(....)....)).)))))...(((((.....((((.....................................(((.(((.......))).)))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a..)..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}}.)))))..)).))...))))...)))).((((...((((.....}.......))))...))))..)))...).)))))).....((((((...((..((.(.(..(((........((((((((((....)))))))))).......)))...(((..((((....(((..(..((((......))))..).)))...))))..))).............)..).))..)).))))))(((((.(..(.......)..)....((.(((((((.((.....((((.(..(((((......)))))..)))))....))....)))).))).))..))))).. Cryo-EM structure of 80S ribosome from mouse kidney; Mus musculus 28S ribosomal RNA 7cpu L7 120 2.82 RF00001 URS000002B0D5_10090 36517592 0003735 0005840 10090 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. Cryo-EM structure of 80S ribosome from mouse kidney; Mus musculus 5S ribosomal RNA 7cpu L8 156 2.82 RF00002 URS00023119A4_10090 36517592 0003735 0005840 10090 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<<<<....>>>>.....<.<<<......>>.............>>>..>...>>>....<<....>><<<<<<<<<.....>>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))(((((((((.....))))))))).................... Cryo-EM structure of 80S ribosome from mouse kidney; Mus musculus 5.8S ribosomal RNA 7cpu S2 1656 2.82 RF01960,RF01959,RF00177 URS00023119C0_10090 36517592 0003735 0005840 10090 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcauuuaucaguggugacucuagauaaccgccgaucgcacgcccuggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuucucgaagcguuuacuuugaaaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgacccccgagcggucggcguaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccugcgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggucggcccacggcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<..<.....<<<......<<....<<<.........<<.....<<.<<.......>>.>>......>>...........<<..<<<<<...<......>..>>>>>..>>...<<<<.<<<<..>>>>>>>>....>>>...>>....>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>>>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....<<.<<<<<<............>>.>>>.>.>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<...<.....>....<<<<<<.<.......<<...<.......>..<<<.......>>>....>>......>.>>>..>>>........<.<<.<<.........................>>.>>.>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<........<<........>>..........<<<<<.<....<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<<<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<.......>>>>.>>>>>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>...>.>>>>>>>.....>.>>>>>......>>>>.>>>.....<<.<<<........<.......<<<<<<<<....>>>>>>>>....>.........>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<.................................>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((..((....((....((..........))...))[))......(((.......(((...(..(.....(((.........((.....((..((.....))..))......))...........((..(((((...(......)..)))))..)).(.((((.((((..)))))))))...)))....))...))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).).....((.((((((..(.......).)).))).).))......((..(...........)..)).........((((([[....(.((((.....((..]])).......))))))))))..)))))).)))..[......(.([[...(.(.((...(((..(...(.....)....((((((.(.......((..((.......)).(.(.......).)....))......).)))..)))........(.((.(...........................).)).)....)....(((.((...(...((((..(((.((((((((...((........))......)))))))).))).......((....))...))))..)...))..))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.((((......)))))))))).)..)))...((..]]))...))...].))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....((((.........((.(((........))).)).......))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((...(...(.((..(((.((((((((.......)))).)))).)))..)).)..).....(((((.....)))))........)))....))).))).....).))))).....).)))))...)).)))).))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(.((((.(((.(((..((((.((...(((((.....(....................)......)))))...)).))))..))).))).)))))..)).))))...).))...)..)..(((((((((....)))))))))}........ Cryo-EM structure of 80S ribosome from mouse kidney; Mus musculus 18S ribosomal RNA 7cpu S6 75 2.82 RF00005 URS0000326EAC_10090 36517592 0030533 0006412 10090 agcagaguggcgcagcggaagcgugcugggcccauaacccagaggucgauggaucgaaaccauccucugcuacca <<<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<.........>>>>>>>>>>>.... (((.(((...(((.......)))..((.((.......)).)).....(((.(........))))))).))).... Cryo-EM structure of 80S ribosome from mouse kidney; tRNA 7cpv L5 3541 3.03 RF02543,RF02540 URS00023119F6_10090 36517592 0003735 0005840 10090 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccgcgcgucgcggcgugggaaauguggcguacggaagacccacuccccgggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggccccggcgcgccgggcucgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggccggccgugcccggggcggaucugcgggggaccgucccccggccggcgaccggccgccgccgggcgcacuuccaccguggcggugcgccgcgaccggcuccgggacggccgggaaggcccgguggggaagguggcucgggcccgaguguuacagcccuccggccgcgcuuucgccgaaucccggggccgaggaagcgucgccgcgcucucccucgggggccgggccgccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcguggucgcgccgucggguccgggggcggucacgcgugagcgcacggggucggcggcgaugucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacgcgugcgcgagucaggggcucguccgaaagccgccguggcgcaaugaaggugaagggccccgcccgggggcccgaggugggaucccgaggccucuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcguacgcguuaggacccgaaagauggugaacuaugcuugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgccgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcaguggaacgggacgggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagugccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcugggucggggccggcgccuagcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacaugcucaucguuuuuucacugacccggugaggcgggggggcgagccccgaggggcucucgcuucuggcgccaagcguccgucccgggcgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgaaggagccucgguuggccccggauagccggguccccgccgggguccggugcggagagccguucgucuugggaaacggggugcggccggaaaggcggccgcccucucgcccgucacguugaacgcacguucguguggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>>..<<<<<<<<<....<<<<..<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>.......>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<......>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<<<<<<<<<<..<..<<<<<<<.<<<.....>>>>>>>>>>..>..>>>>...>>>>>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<<<<<<<<<<<<<<<<<...<<.<<<<.<<.<<<<......<<<<<<..>>>>>>.......>>>>>>>>>>......>>>>>>..>>>>>>>>>>>.............<<<<<<.<<<<..>>>>.<<<<<<<<<<<.<<<<<<<<<<..<<<<<.<<<<<.<...........>..>>>>>.>>>>.>...>>>>>>>.>>>...>>>>.>>>>>.>>...>>>>>>.....>>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<.....>>>>>>>..<<<<<...<<<..<<<...[[...{[[>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<.....<<<.<<<<<<<<<...<<<....<<<..<.<<<....<<.............>>..>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.........>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<..<...................................................>.>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<...]].}..]]......................>>>>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<...........>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<..<<<.<.<...>..>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<...............<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<...................>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<<<<<<....>>.>>>>>>>>>>...<<<<<.....<<<<.....................................<<<<<<<<<..>>.>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>><<<<....>>>>>>)))].....<<<<<<<..<<<..)))))).>>>>>>>>>>.........>>>>..>>>>>>.......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<....<<<<<.................>>>>>..<<<<....<<<<...<<<.<<<<<<<]]].>>>>>..>>.>>>..>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.....<<<<<<...<<..<<.<....<<<........<<<<<<<<<<....>>>>>>>>>>.......>>>...<<<..<<<<....<<<<...<<<<<......>>>>>..>>>>...>>>>..>>>................>.>>..>>.>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<....<<<<<......>>>>>...>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((...((((((((((.....)))))).)))).....)))....(((((((((....(((...(((((((..({((((......)))))....[[(...).(((....}]])))...).))))))........)))...)))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....((((((((((((((((((..(..(((.(((.(((.....)))))).)))...).))))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((.((((.((.((((......(.((((())))).).......))))))))))......))))))..))))))))))).............((((((.((((())))).(((((((((((.((((((((((..(((((..((((................))))..)))).)...))))))).)))...)))).))))).))...)))))).....))).)))))...)))))...)))))))).[((((........))))((((((..(.(((((((((((((..(((..(((((........))))..)..)))...((....))...(((((((.....)))))))..(((((...(((..(((........[[[)))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((.(((((.((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))..).)))).)))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((.(((((((.....(((.((((((((....(((....(((..(.(((.......................))).)..)))..)).)....))))))...(((((((((.(......))))))))))....))))))))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.....{..............................................................)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((...]]]..............(...)........)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...((....(((....)))...(.)....((.((((.............))))))......))....))...(((((........)))))]]((((....(((((...((.(.......).))..((((....)))...(...((((((...(((((((((((((((((((((((..{{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....(((((((.......))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((...................)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((....(((.....((((....)))).....))).))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.(.......((((.((((((..(((((.(((((((((.((((((((.............))))))))...(((((.....((((.....................................(((.((((....).))).)))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a..)..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}}.)))))..)).))...))))...)))).((((...((((.....}.......))))...))))..)))...).)))))).....((((((...((..((.(.(..(((........((((((((((....)))))))))).......)))...(((..((((....((((.(..((((......))))..)))))...))))..))).............)..).))..)).))))))(((((.(..(.......)..)....((.(((((((.((.....((((.(..(((((......)))))..)))))....))....)))).))).))..))))).. Cryo-EM structure of 80S ribosome from mouse testis; Mus musculus 28S ribosomal RNA 7cpv L7 120 3.03 RF00001 URS000002B0D5_10090 36517592 0003735 0005840 10090 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. Cryo-EM structure of 80S ribosome from mouse testis; Mus musculus 5S ribosomal RNA 7cpv L8 156 3.03 RF00002 URS00023119A4_10090 36517592 0003735 0005840 10090 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<<<<....>>>>.....<.<<<......>>.............>>>..>...>>>....<<....>><<<<<<<<<.....>>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))(((((((((.....))))))))).................... Cryo-EM structure of 80S ribosome from mouse testis; Mus musculus 5.8S ribosomal RNA 7cpv S2 1637 3.03 RF01960,RF01959,RF00177 URS00023119C0_10090 36517592 0003735 0005840 10090 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcauuuaucaguggugacucuagauaaccgccgaucgcacgcccuggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuucucgaagcguuuacuuugaaaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgacccccgagcggucggcguaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccugcgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<......<<....<<<.........<<.....<<..<.......>..>>......>>...........<<..<<<<<...<......>..>>>>>..>>...<<<<.<<<<..>>>>>>>>....>>>...>>....>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....<<..<<<<<............>>.>>>...>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<...<.....>....<<<<<<.<.......<<...<.......>..<<<.......>>>....>>......>.>>>..>>>........<.<<.<<..<<................>>...>>.>>.>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<.......>>>>.>>>>>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<<<<<<....>>>>>>>>....>.........>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<....<..>......>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..(.....(((.........(..............................)...........((..(((((...(......)..)))))..)).(.((((.((((..)))))))))...)))....)).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).)......(..((((..............).)))...).......((..(...........)..)).........((((([[....(.((((.....((..]])).......))))))))))..)))))).)))..[......(.([[...(.(.((...(((.((...(.....)....((((((.(.......(...(.........).(((.......))).....)......).)))..)))........(.((...............................)).)....))...(((..(...(...((((..(((.((((((((...((........))......)))))))).))).......((....))...))))..)...)...))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.((((......)))))))))).)..)))...((..]]))...))...].))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....((((.........((.(((........))).)).......))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((...(...((((..((.(((((((((.......)))).)))).)))..))))..).....(((((.....)))))........)))....))).))).....).))))).....).)))))...)).)))).))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(.((((.(((.(((..((((.((...((.((..............)).))...)).))))..))).))).)))))..)).))))...).))...)..)..(((((((((....)))))))))}........ Cryo-EM structure of 80S ribosome from mouse testis; Mus musculus 18S ribosomal RNA 7cpv S6 75 3.03 RF00005 URS0000326EAC_10090 36517592 0030533 0006412 10090 agcagaguggcgcagcggaagcgugcugggcccauaacccagaggucgauggaucgaaaccauccucugcuacca <<<<.<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<.........>>>>>>.>>>>.... (((...(..((((.......)))).((.((.......)).)).....(((.(........)))))...))).... Cryo-EM structure of 80S ribosome from mouse testis; Met-tRNA 7ctt Q 16 3.2 URS00021ED9A2_2697049 33521757 2697049 uucuccuaagaagcua ................ ................ Cryo-EM structure of Favipiravir bound to replicating polymerase complex of SARS-CoV-2 in the pre-catalytic state.; Primer-RNA (5'-R(P*UP*UP*CP*UP*CP*CP*UP*AP*AP*GP*AP*AP*GP*CP*UP*A)-3') 7ctt T 18 3.2 URS00021ED98B_2697049 33521757 2697049 acuagcuucuuaggagaa .................. .................. Cryo-EM structure of Favipiravir bound to replicating polymerase complex of SARS-CoV-2 in the pre-catalytic state.; Template-RNA (5'-R(P*AP*CP*UP*AP*GP*CP*UP*UP*CP*UP*UP*AP*GP*GP*AP*GP*AP*A)-3') 7cxm I 25 2.9 URS00021ED98C_2697049 33208736 2697049 gcgguaguagcaugcuagggagcag ......................... ......................... Architecture of a SARS-CoV-2 mini replication and transcription complex; RNA (25-MER) 7cxm J 26 2.9 URS00021ED8F4_2697049 33208736 2697049 agcugcucccuagcaugcuacuaccg .......................... .......................... Architecture of a SARS-CoV-2 mini replication and transcription complex; RNA (26-MER) 7cxn I 25 3.84 URS00021ED98C_2697049 33208736 2697049 gcgguaguagcaugcuagggagcag ......................... ......................... Architecture of a SARS-CoV-2 mini replication and transcription complex; Primer RNA 7cxn J 26 3.84 URS00021ED8F4_2697049 33208736 2697049 agcugcucccuagcaugcuacuaccg .......................... .......................... Architecture of a SARS-CoV-2 mini replication and transcription complex; Template RNA 7cyq I 25 2.83 URS00021ED9A9_2697049 33232691 2697049 gcgguaguagcaugcuagggagcag ......................... ......................... Cryo-EM structure of an extended SARS-CoV-2 replication and transcription complex reveals an intermediate state in cap synthesis; Primer 7cyq J 27 2.83 URS00021ED92C_2697049 33232691 2697049 ugacugcucccuagcaugcuacuaccg ........................... ........................... Cryo-EM structure of an extended SARS-CoV-2 replication and transcription complex reveals an intermediate state in cap synthesis; Template 7d1a A 692 3.8 RF00029 URS00021ED979_1359 33021674 0000373 1359 gugcgcccagauaggguguuaagucaaguaguuuaagguacuacucuguaagauaacacagaaaacagccaaccuaaccgaaaagcgaaagcugauacgggaacagagcacgguuggaaagcgaugaguuaccuaaagacaaucggguacgacugagucgcaauguuaaucagauauaagguauaaguuguguuuacugaacgcaaguuucuaauuucgguuaugugucgauagaggaaagugucugaaaccucuaguacaaagaaagguaaguuaugguuguggacuuaucuguuaucaccacauuuguacaaucuguaggagaaccuaugggaacgaaacgaaagcgaugccgagaaucugaauuuaccaagacuuaacacuaacuggggauacccuaaacaagaaugccuaaaggaggaaaaaggcuauagcacuagagcuugaaaaucuugcaaggguacggaguacucguaguagucugagaaggguaacgcccuuuacauggcaaagggguacaguuauuguguacuaaaauuaaaaauugauuagggaggaaaaccucaaaccaacaauggcaauuuuagacaauaacagagccguauacuccgagagggguacguacgguucccgaagaggguggugcaaaccagucacaguaaugugaacaaggcgguaccucccuacuucac .....<<<<.....<<<<<<<<<<<..<<<<.........>>>><<<<......(((.>>>>.<<<<.<<<<<<...<....<.<<....>>>.....>............>>>>>>...<<<<..<<..<.<...((.......>.>....>>...>>>>..>>>>...<<<<.....<<<<..<<<.......>>>....<<...<<<<.......<<.......>>...............))...........<<<<<<....<<<<<<<<.........>>>>>>>>.))).........>>>>>>......<<<<......>>>>......>>>>.....>>..>>>>.....>>>>..........>>>>>>>>>>>...>>>>..<<<<.....<.......<<<..>>>........<<<<..<....>..>>>>..........>...>>.>>....<<.<<<.............<<<<<.....>>>>>...........>>>..>>.<<<<<<<............................<<.....>>........................>>>>>>>.<<<<<<<<<<<<<<....>>>>>..>>>>>>>>>..<<<.<<<<.<..<<...........<....>............>>...>>>>>..>>>.. .....((.......(((((((((((..((((.........))))((.(......[[[.).)).((((.((((((..........((....))...................))))))...(((((..(....(.......[....)......)..).))))..))))....(.(............................((....(.....(.(.(.........))...(.......]............)....(((.....(..(((((.........)))))..).]]]..........)))....)....((........)).........)......))...........).)...........))))))))))).....))(...((.......(.....(.(..).)........((...((....))...)).........)....))...)...((.(...............(((((.....)))))..............).))...(((((........((.(.....(...((.(....(.....)......)))..).....).).)...)))).).....(((.(((((((....)))))..)).))).....((((((((..(..(....(......(....)........)...)...).)))).)))).. cryo-EM structure of a group II intron RNP complexed with its reverse transcriptase; RNA (692-MER) 7d1a B 12 3.8 URS00021ED95B_1359 33021674 1359 cacauccauaac ............ ............ cryo-EM structure of a group II intron RNP complexed with its reverse transcriptase; RNA (5'-R(P*CP*AP*CP*AP*UP*CP*CP*AP*UP*AP*AP*C)-3') 7d4i 3A 216 4.0 RF01846 URS000231196A_559292 0006396 0005730 559292 ucgacguacuucaaggaucauuucuauaggaaucgucacucuuugacucuucccaacuugguugaugagucccauaaccuuuguaccccagagugagaaagcuuggccgaauccucgguucggccacuauugccguugcauuuuauggcgcgaugaucuugacccauccuaucuucgaagauaggauggguggguacaaauggcagucugacaagu .......................................................<<<<<.................<<<<<<<<<<<....<...<...<..<<<<<<<<<<...>>>>>>>>>>.>...<<<<..........>>>>.>......>..<..<<<<<<<<<<<<..>>>>>>>>>>>>.>>>>>>>>>>.>>........>>>>> .......................................................(((((......(..........(((((((((((....(...(......(((((((..(...)..))))))).....(((.....().....))).)......)...(..(((((((((((())))))))))))..)))))))))).))....)...))))) Cryo-EM structure of 90S small ribosomal precursors complex with the DEAH-box RNA helicase Dhr1 (State F); U3 snoRNA 7d4i 5A 118 4.0 URS000007769E_559292 559292 ugcgaaagcaguugaagacaaguggcuugucguucguuaaaauggccucgucgcgaaggggaaacucaaagagugcuaucggagugcgcgagagcauuuccggcagcagaucagcugu <<<....>>>...<<<<<<<<<<.>>>>>>>.>>>............................................<<<<<<<<......>>>>.>>>>.<<<<......>>>>. (((....)))...((((((((((.))))))).)))............................................((((((((.()...)))).)))).((((.(..).)))). Cryo-EM structure of 90S small ribosomal precursors complex with the DEAH-box RNA helicase Dhr1 (State F); 5' ETS 7d4i SA 1337 4.0 RF01960,RF01959,RF00177 URS00023119EF_559292 0003735 0005840 559292 aagauaguuaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaaaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagagucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacgggagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaagcucguaguugaacugggcccgguuggccgguccgauuuucgugacuggccaacggggccuuuccuucugguuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggguuugguucuaucuaggaccaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacguagggaucgggugguguuuuuuuaaugacccacucggcaccuuggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcucaacacggggaaacucaccagguccagacacaauaaggauugacauucuugauuuugugggugguggugcauugaugcccuuguucugggcccgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuuggaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaauuccguaggugaaccugcggaaggaucauuaaaga .................................<<<<<<...<.<..........<<<.<<<..<<....<<.....................>>.>>.......<<<..<<..<<....<<<..................<.....<<.<<<.....>>>.>>......>.........<<<<<..<<....>>..>>>>><...<<<<<<..<<<<..>>>>..............>>>>>>.....>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>.>>>>>>.........<<<....<<<.....>>>..>>>.......>.>.....<<.<<<<..<<<<....>>>>..>>>>..>>......<<..<...........>..>>.........<<<<<<.......<<<....>>>..................>>>>>>..>>>>>>.....<.<<...<<<.<<...<<<<<.<<<<<<<<<<<<<<...>>>.>>>>>>>>>>>.>>>>>............<<<<<.<<...........<<.......>>.<<<.....>>>............>>.>>..>>>............<..<.......>..>......>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>..>.>>>>.>>>...>>>...>>.>..<<<..<<<<<<<<.<<..........>>>>>>>>>>..>>>..................<<.........>>.....<<<<<<<<<<<<..<<.<<<<<<..<<<.<<<<.......................<<......<<<<<.....................>>>>>......<<<........>>>.....>>......>>>>.>>>.....<<<<<<<.............<<..<<<<....>>>>..>>...>>>>>>>......<....<<<<<<..........>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>............>>>>>..<<<<.<<....<<<<<<<<.<<<....<<..........<<<.<<<..<<<......>>>..>>>.>>>..........>>....>>>.>>>>>>>>...>>.>>>>..<<<<<<<<<....>>>>>>>>>............. .............................(...((((((...(.(...(......(((.(((..((....((.....................))[)).......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((..(((....))).....(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......))).)))))).......(.(((...((((.]...))).))))).)....).).....((.((((...(((....)))...))))..))......(.(.(...........))..).........(((((((......(((....)))...............)..))))))..))))))..)..(.((...(((.(....(((((.((((((((((((((...))).))))))))))).)))))............(((...((...........(.........)..((.....)).............)).....)))............(..(.......)..).......)...((...((.((...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)).))....)..))).)..)).)..(((..((((((((.(((........)))))))))))..)))..................((.........)).....((((((((((((..((..(((((..(((..(((.......................(...(...(((((.(..................))))))....(.((..........)))..)..)......)))..))).(...(((((((.............((..((((....))))..))...)))))))......(....((((((..........))))))....)..)..))))).....((((((((.......))))))))......))...))))))).(......)...)))))..((((.((...((((((.(..(((..(.((..........((..(.(..((.(....).))..).)..))..........)).)..)))..).))))))..)).))))..(((((.((......)).)))))............. Cryo-EM structure of 90S small ribosomal precursors complex with the DEAH-box RNA helicase Dhr1 (State F); 18S rRNA 7d5s 3A 175 4.6 RF01846 URS0000B21E09_559292 0006396 0005730 559292 gucgacguacuucauaggaucauuucuauaggaaucgucacucuuugacucuucaaaagagccacugaauccaacuugguugaugagucccauaaccuuuguacccagugagaaauugccguugcuauggcgcgaugaucacccauggguggguacaaauggcagucugacaagu .........................................................................<<<<<.................<<<<<<<<<<..<.........<<<<......>>>>.......>.<<<<..>>>>.>>>>>>>>.>>........>>>>> .........................................................................(((((......(..........(((((((((((.(...(.....((((......)))).)......)((((..))))))))))))).))....)...))))) Cryo-EM structure of 90S preribosome with inactive Utp24 (state A2); U3 snoRNA 7d5s 5A 523 4.6 URS000007769E_559292 559292 ugcgaaagcaguugaagacaaguggcuugucguucguuaaaauggccucgucaaacgguggagagagucgcuaggugaucgucagaucugccuagucucuauacagcguguuuaauugacauggguugaugcguauugagagauacaauuugggaagaaauucccagaguguguuucuuuugcguuuaaccugaacagucucaucgugggcaucuugcgauuccauuggugagcagcgaaggauuugguggauuacuagcuaauagcaaucuauuucaaagaauucaaacuugggggaaugccuuguugaauagccggucgcaagacugugauucuucaaguguaaccuccucucaaaucagcgauaucaaacguaccaccgugaaacaccgggguaucuguuugguggaaccugauuagaggaaacucaaagagugcuaugguauggugacggagugcgcuggucaagaguguaaaagcuuuuugaacagagagcauuuccggcagcagagauuucagcugu <<<....>>>...<<<<<<<<<<.>>>>>>>.>>>..............<<<<<<<<.<<...<<<<..<<<<<<<<<<<....>>>>.>>>>>>>>>>>...>>.>>>......>>>>>..<<<<<..........<<<<<<<<<<.<<<<<<<<....>>>>>>>.>>>>>>>>>>>........>>>>>.......<<<<<<<<<<<...........>>>>>.>>>>>>.........................<<<...>>>.........................<<<<<..<<<<<<<..<<<<...<<<<<....>>>>>.>.>>>..>>>>.>>.>>>>>>.....<<<<<<...<<<<<<<<<<<<<.<<<........>>>>>>>.>.>>>>>>>>....>>>>>>.................................<<<<.<<<.<<<.<<<<<<<<......>>>>.>>>>.>>>...>>>..>>>><<<<<.<<<..>>>.>>>>> (((....)))...((((((((((.))))))).)))..............((((((((.(((..((((..(((((((((((....)))).))))))))))).).)).)))......)))))..(((((.....(.(...((((((..(.((((((((....)))))))).)..))))))..).)....))))).....(.((((((((((((.....)....))))).)))))))........................(((...))).........................(((((..(((((((..((((..((((((....))))).)))))..)))).)).)))))).....((((((....((((((((((((.(((........))))))).).))))))).....)))))).................................((((.(((.(((.((((((((......)))).)))).)))...)))..)))).((((.((.().)).)))). Cryo-EM structure of 90S preribosome with inactive Utp24 (state A2); 5' ETS 7d5s SA 859 4.6 RF01960,RF01959,RF00177 URS00021ED968_559292 0003735 0005840 559292 aagauaguuaucugguugauccugccaguagucauaugcuugucucacaaauuagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaggcucguaguugaacuuagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaacuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcucaacacggggaaacucaccagguccagacacaauaaggauugacauucuugauuuugugggugguggugcauugaugcccuuguucugggccacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauauucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaa ............................<<<<.<<<<<<.............................<<<<<<<.<<<<<....>>>>>.>>>.>>>>......<<..<...........>..>>.........<<<<<<.......<<<....>>>..................>>>>>>..>>>>>>>>>>.........<..<.<<...<<<.......<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>..>.>>>>.>>>...>>>...>>.>......<<<<<...<...<<<<.........>>>>...>>>>>>...>....................<<.........>>.....<<<<<<<<<<<<..<<.<<<<<<..<<<.<<<<.......................<<.<....<<<<<........<.....>......>>>>>......<<<........>>>...>.>>.......>>>>.>>>.....<<<<<<<............<<<..<<<<....>>>>..>>>............>>>>>>>.......................>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>............>>>>>..<<<..<<....<.<<<..<.<<<..<.<<......<<<<<<<.<<<<.<<<<....>>>>.>>>>.>>>>>>>......>>.>..>>>.>..>>>>....>>..>>>................<<<<<<<<<....>>>>>>>>> ............................((((.((((((...(.(...............).).....(((((((((((((....))))))))).))))....(.((..(...........)..))......)..(((((((......(((....)))...............)..))))))..))))))))))..............((...(((......(((.(((.((...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)).)))..))..))).)..))........((((....(...((.(.........).))...).))))........................((.........)).....((((((((((((..((..(((((..((((.(((.......................(...(...(((((.....................)))))....(.((..........)))..)..).......)))).))).(...(((((((............(((..((((....))))..)))............))))))).........(...)......)..))))).....((((((((.......))))))))......))...))))))).(......)...)))))..((((.((.....(....(..(((..(.((..(...((.((((.((((.((.(....).)).)))).)))).))...)..)).)..)))..)...).....)).))))................(((((((((....))))))))) Cryo-EM structure of 90S preribosome with inactive Utp24 (state A2); 18S rRNA 7d5t 3A 167 6.0 RF01846 URS0000B21E09_559292 0006396 0005730 559292 ucgacguacuucaaggaucauuucuauaggaaucgucacucuuugacucuucccaacuugguugaugagucccauaaccuuuguaccccagagugagaaauugccguugcauuuuauggcgcgaugaucuugacccauggguggguacaaauggcagucugacaagu .......................................................<<<<<.................<<<<<<<<<<<....<...<.....<<<<..........>>>>.>......>..<..<<..>>.>>>>>>>>>>.>>........>>>>> .......................................................(((((......(..........(((((((((((....(...(.....(((.....().....))).)......)...(..(())..)))))))))).))....)...))))) Cryo-EM structure of 90S preribosome with inactive Utp24 (state F1); U3 snoRNA 7d5t 5A 43 6.0 URS000007769E_559292 559292 ggaaacucaaagagugcuaucggagugcgcgagagcauuuccg ....................<<<<<<<<......>>>>.>>>> ....................((((((((.()...)))).)))) Cryo-EM structure of 90S preribosome with inactive Utp24 (state F1); 5' ETS 7d5t SA 1189 6.0 RF01960,RF01959,RF00177 URS00023119EF_559292 0003735 0005840 559292 aagauaguuaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaaaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagagucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacgggagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaagcucguaguugaacugggcccgguuggccgguccgauuuucgugacuggccaacggggccuuuccuucugguuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggguuugguucuaucuaggaccaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacguagggaucgggugguguuuuuuuaaugacccacucggcaccuuggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcgcgcgcuacacugacggagccagcgaaacuccgucgugcugggaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaauuccguaggugaaccugcggaaggaucauuaaaga .................................<<<<<<...<.<..........<<<.<<<..<<....<<.....................>>.>>.......<<<..<<..<<....<<<..................<.....<<.<<<.....>>>.>>......>.........<<<<<..<<....>>..>>>>><...<<<<<<..<<<<..>>>>..............>>>>>>.....>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>.>>>>>>.........<<<....<<<.....>>>..>>>.......>.>.....<<.<<<<..<<<<....>>>>..>>>>..>>......<<..<...........>..>>.........<<<<<<.......<<<....>>>..................>>>>>>..>>>>>>.....<.<<...<<<.<<...<<<<<.<<<<<<<<<<<<<<...>>>.>>>>>>>>>>>.>>>>>............<<<<<.<<...........<<.......>>.<<<.....>>>............>>.>>..>>>............<..<.......>..>......>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>..>.>>>>.>>>...>>>...>>.>..<<<..<<<<<<<<.<<..........>>>>>>>>>>..>>>..................<<.........>>.....<<<<<<<<<<<<..<<.<<<<<<..<<<.<<<<.>>>>.>>>.....<<<<<<<.........>>>>>>>......<...>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>............>>>>>..<<<<.<<....<<<<<<<<.<<<....<<..........<<<.<<<..<<<......>>>..>>>.>>>..........>>....>>>.>>>>>>>>...>>.>>>>..<<<<<<<<<....>>>>>>>>>............. .............................(...((((((...(.(...(......(((.(((..((....((.....................))[)).......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((..(((....))).....(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......))).)))))).......(.(((...((((.]...))).))))).)....).).....((.((((...(((....)))...))))..))......(.(.(...........))..).........(((((((......(((....)))...............)..))))))..))))))..)..(.((...(((.(....(((((.((((((((((((((...))).))))))))))).)))))............(((...((...........(.........)..((.....)).............)).....)))............(..(.......)..).......)...((...((.((...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)).))....)..))).)..)).)..(((..((((((((.(((........)))))))))))..)))..................((.........)).....((((((((((((..((..(((((..(((..(((.)))..))).(...(((((((.........)))))))......(...)..)..))))).....((((((((.......))))))))......))...))))))).(......)...)))))..((((.((...((((((.(..(((..(.((..........((..(.(..((.(....).))..).)..))..........)).)..)))..).))))))..)).))))..(((((.((......)).)))))............. Cryo-EM structure of 90S preribosome with inactive Utp24 (state F1); 18S rRNA 7d63 3A 175 12.3 RF01846 URS0000B21E09_559292 0006396 0005730 559292 gucgacguacuucauaggaucauuucuauaggaaucgucacucuuugacucuucaaaagagccacugaauccaacuugguugaugagucccauaaccuuuguacccagugagaaauugccguugcuauggcgcgaugaucacccauggguggguacaaauggcagucugacaagu .........................................................................<<<<<.................<<<<<<<<<<..<.........<<<<......>>>>........><<<<..>>>>.>>>>>>>>.>>........>>>>> .........................................................................(((((......(..........(.(.(((((((.(...(.....((((......)))).)......)((((..))))))))))).)..)....)...))))) Cryo-EM structure of 90S preribosome with inactive Utp24 (state C); U3 snoRNA 7d63 5A 192 12.3 URS000007769E_559292 559292 ugcgaaagcaguugaagacaaguggcuugucguucguuaauggccucguccagcgaaggauuugguggauuacuagcuaauagcaaucuaggaaacucaaagagugcuaugguauggugacggagugcgcuggucaagaguguaaaagcuuuuugaacagagagcauuuccggcagcagagauuucagcugu <<<....>>>...<<<<<<<<<<.>>>>>>>.>>>........................................<<<...>>>....................................<<<<.<<<.<<<.<<<<<<<<......>>>>.>>>>.>>>...>>>..>>>><<<<<.<<<..>>>.>>>>> (((....)))...((((((((((.))))))).)))........................................(((...)))....................................((((.(((.(((.((((((((......)))).)))).)))...)))..)))).((((.((.().)).)))). Cryo-EM structure of 90S preribosome with inactive Utp24 (state C); 5' ETS 7d63 SA 1331 12.3 RF01960,RF01959,RF00177 URS0002311A0A_559292 0003735 0005840 559292 aagauaguuaucugguugauccugccaguagucauaugcuugucucagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaaggcucauuaaaucaguuaucguuuauuugauaguuccaugguauaacugugguaauucuagagcuaauacaugcuaaucucgacccuuuggaagagauguauuuauuagaucaaugucuucggacucuuugaugaaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggccaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcagaagcucguaguugaacuggcccgguuggccgguccggauuuccaacggggccuugguucuauuuucuaggacugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagacuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcucaacacggggaaacucaccagguccagacacaauaaggauugacauucuugauuuugugggugguggugcauugaugcccuuguucugggccacgcgcgcuacacugacggagccagcgagucuacccuuggccgagaggucuugggugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaaguuuccguaggugaaccugcggaaggaucauuaaaga ............................<<<<.<<<<<<........<<<.<<...<<....<<....<<..........>>...>>.>>.....<<<.......<<<..<<..<<....<<<..........<.....<<.<<.......>>.>>......>.......<<<<............>>>>.....<<<<<...<<<<..............>>>>...>>>>>.........<<<<...<<.....>>..>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>.....<<...............>>..>>>.<<.<<<..........>>>.>>.<.<<....>>.>....>>>>>......<<<....<<<.....>>>..>>>...............<<<<<<<.<<<<<....>>>>>.>>>.>>>>......<<..<...........>..>>.........<<<<<<.......<<<....>>>..................>>>>>>..>>>>>>>>>>.........<....<.<<...<<<.<<..<<<<<.<<<<<..<.......>..>>>>>.>>>>>.<..<<..<...>..>>.>....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>..<<...<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>..>>.....>....................<<.........>>.....<<<<<<<<<<<<..<<.<<<<<<..<<<.<<<<.......................<<.<....<<<<<........<.....>......>>>>>......<<<........>>>...>.>>.......>>>>.>>>.....<<<<<<<.............<<..<<<<....>>>>..>>......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>............>>>>>..<<<<.<<.....<<<<<<<.<<<..<.<<......<<<<<<<...<<.<<<......>>>.>>...>>>>>>>......>>.>..>>>.>>>>>>>....>>.>>>>.....<<<<<<<<<....>>>>>>>>>............. ............................((((.((((((...(.(..(((..(...((....((.....(..........)....)).)).....(((.......(((..((...(....(((..........(.....((.(.(.....).).))......).......((((............)))).(.(.((((.....((..(.(....).)....)).....)))).)...).(.((((...(((..).))..)))))...)))...).))..)))..((....((.....((((((((.......)))))))).))......).).....(.................)..))).((.(((..........))).))...(.......).....).)))......(((...((((.....))).)))).......).).....(((((((((((((....))))))))).))))....(.((..(...........)..))......)..(((((((......(((....)))...............)..))))))..))))))))))..............(.((...(((.((..(.(((.(((((......(.)....))))).))).).....(.........).......))...(((.(((.((...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)).)))..))..))).)..)).).(((...(((..((((((((.(((........)))))))))))..)))..)).)........................((.........)).....((((((((((((..((..(((((..((((.(((.......................(...(...(((((.....................)))))....(.((..........)))..)..).......)))).))).(....((((((.............((..((((....))))..))......)))))).......(....((((((..........))))))....)..)..))))).....((((((((.......))))))))......))...))))))).(......)...)))))..((((.((.....((((((..(((..(.((........(((((.(.((.((..(...).)).)).).)))).).......)).)..)))..))))))....)).)))).....(((((.((......)).)))))............. Cryo-EM structure of 90S preribosome with inactive Utp24 (state C); 18S rRNA 7d6z 2 65 3.4 RF00005 URS00021ED932_562 33761323 0030533 0006412 562 gggugauagcucaggggagagcaccucccuacaggaggggucggcggcgaucccgucaucaccca .<<<<<..<<<<......>>>>.<<<<<.....>>>>>....<.<<<.....>>>.>.>>>.>>. ..(.....(((........))).(((((.....)))))....(.(((.....))).)......). Molecular model of the cryo-EM structure of 70S ribosome in complex with peptide deformylase and trigger factor; E-site tRNA 7d6z 3 70 3.4 RF00005 URS000009EE82_562 33761323 0030533 0006412 562 ggagcggaguucagucgguuagaauaccugccuuccgcaggggucgcgggcgagucccgccguuccgcca <<<<<<<.<<<<.........>>>>.<<<<<.....>>>>>.....<<<<.....>>>>>>>>>>>.... (((.(((.((((.........)))).(((((.....))))).....((((.....))))))).))).... Molecular model of the cryo-EM structure of 70S ribosome in complex with peptide deformylase and trigger factor; P-site tRNA 7d6z 4 66 3.4 RF00005 URS000021B2C1_562 33761323 0030533 0006412 562 gggucguagcucaggguagagcaguugacuuuacaauugcgcaggcgaauccugcacgacccacca <<<<<<<.<<<<......>>>>.<<<<......>>>>...<<<<.......>>>>>>>>>>>.... (((((((.((((......)))).((((......))))....((.........)).))))))).... Molecular model of the cryo-EM structure of 70S ribosome in complex with peptide deformylase and trigger factor; A-site tRNA 7d6z A 2903 3.4 RF02540,RF02541 URS000080E25C_562 33761323 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<.........>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<...........>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<.<<....>>.>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>.>........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<..<<....>>...>>>>>..>....>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<.<<....<.......<<<<<<<......>>>>>>>....>..............>>>....>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((.((.........))..))...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((..((..((...........))..))......(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((.((....)).))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((((...........(...(...........(((.(((......))).)))..................)..)...)))).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))).)[((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..)))))))))......}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Molecular model of the cryo-EM structure of 70S ribosome in complex with peptide deformylase and trigger factor; 23S ribosomal rRNA 7d6z B 118 3.4 RF00001 URS0000366A67_562 33761323 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))). Molecular model of the cryo-EM structure of 70S ribosome in complex with peptide deformylase and trigger factor; 5S ribosomal rRNA 7d6z f 1539 3.4 RF00177,RF01959,RF01960 URS000080DDC0_562 33761323 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<.<..>.>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((..(..((.(((.((......)).)))..)))...)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..(......))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((.(.........)))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))............((((....))))...........((.(((((...(..(.((((((((.......)))))))).)...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))...((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Molecular model of the cryo-EM structure of 70S ribosome in complex with peptide deformylase and trigger factor; 16S ribosomal rRNA 7d80 A 2903 4.1 RF02540,RF02541 URS000080E25C_562 33761323 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<...........>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<.............>...>>.........<<......>>...>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<.<......>.>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<......>>>>...>>>>>>...>>>...>>>.>........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<..<<.........<.....<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<..<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>.>......>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>>>..>>.>>>>>>>..>..>>..>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<..<<..............<<<....<<......<<...<<......>>...>>...>>..............>>>.....>>..>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<.<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>..>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<...<<<<<<<<<<.)))..>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<.........>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((..((..((......((...((((((((((((......((((((.[..[[[.)))....(((.(((...(((]]]..].))).......))).)).).)))....(((....)))((((((......)))))).(((((((((.........))))))))).))...((((((...................))))).).........((....))...((.((.....((.....))....).)))...((((.((((......(((.(((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))))))).)))...))))...)....((((.(....[.........)))))......((.((]..{{{)).))..)))......)).))))))).).................(....).....)).........(((.......)))...................))..))..)).....(.((....(((((......)))))....))...(.(........).).(((..(....(((.((((..(((..(.....((.....)).....)...((....))..((((.....)))).....)))..)))).)))..((.(...(.((((.....((((..((((.(......((((((......)))))).......)...(((.(.(((........))).))))..).)))..)))).(.((.......))...)..)))).)......).))..((((((....(((((....))))).((((..((..((.(((((((.....(((...(((.((((.....(...............)....)))).)))..)).).....)))))).).)..)))..))).)...(...(((.((......).))).)..).....((......)).....(((.(.....((([[....(.((((.......(.....((....(((..(((.......(.(((...(..(.............)..)..........(.(......).)..))).)...)))..)))...))............]].).....)))))))).....))))....(((..(......)))).......))))))...((((...(((.......((((.((....)).))))....)))..)))).........)..)))(......((........(((.......)))...((((....((.(..(...((((..(...((.....)).)..)))....[[(((.(((.(.(((...(.(.....))...)))..))))..(((((........)))))]]((((((.((((((....((.....(((...(((..((((((((((((...[[[.).))))))((..((((....((.((((((((.((.....))))))))))...))...[))))...))(...((((....))))....))))))...)))....)))(..)......))....))....))).))))))).))).).).....((......)).).)).((((.....))))..))))..((((....(.((((((.(........(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(...(((((...((.........))...(((((((.....(((....))).......))))))).}(....(((..((.((((..(((........(((((..((....))...)))))........)))))))...)))))(((((.........)))))........((..........(((...........)))..)..).......)...)).)))...).)....).)))))).).)))))).....)).[..(((((......].)))))..((...(((..((.((......(.((.(.(.(.(.(((((...(.(((((.(((((((((((.(((..............(.............(((.(.(......).).)))....................).....))).)))))))))))...((..((((((.....)))))).))....))))).)....)))))..(((......[))).((.(...........].).))..[((....((((.....(((((.........))))).....((][.[[[))......))).)...((((..(.....<....)..)))).(((....))).))]]].]......(.((((.((..}}}...)))))).).......>......))....)))).)......((((....((((((...((.......))...)))))).....)).).).......(..(((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...).).......((((..(....)...))))....))..)).)))...)){...(((((((...((.(...((((((.....(....)....))))).).((.((...((.(...(((((((....]]].....))..)))))...).)).)).))....((....((((.............))))....))..).))..}....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(.(((....))).)...))...))))).))).....))..).))))))))). Molecular model of the cryo-EM structure of 70S ribosome in complex with peptide deformylase, trigger factor, and methionine aminopeptidase; 23S ribosomal RNA 7d80 B 1539 4.1 RF00177,RF01959,RF01960 URS000080DDC0_562 33761323 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<.............<.....<....>....>............>>......<<.......<<<<<<<..<<...<<.<......<<.....<<..<......>..>>......>>.......<<<....>>>.......<<<<.........>>>>......>.>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>.>>..>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>...<<<.......<<<....>>>......>>>......<<<<<..........<<<<...........>>>>............>>>>>.......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<.<.<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>..>>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<...<<.....>>.>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<.<<.....<<<..<<...<<<....>>>...>>....>>>.....>>.>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[...)))).((...(((((..(....((.(....(((.(((..((.............(...............)............))......(((.......((((.(..((...(((.....(.(.(.....(..((....))...)......)).)......((....))........(...............).......)))..)).).)))).((((...(((..((((((((.......))))))))))).....))))..((.(((.(....).))...).))))).(((((............))))).((((....))))...)))))).).....(..((...(..(.......)..))).)..).)....)...(((......((((....)))).....)))....(.(((....((...(........................)...)..)...)))....)..((((([[[...(((((........]]].........))))))))))..)))))..))..........((([[...(.((((.......(.((((..((((((((((......((((((.....))))))....))))))))..)).)))).)..(((((((......((((((.....((((((....((........)).......))))))............((....)).)))))).....)).))))..)......))))....((..((...((...((((.........))))...))))..))......{...((((....((((((.(((((.....))))).))))))...((..]])).......)))))))).(((......((((....))))....)))....]].](((((...(((((.((..(((((..(((((...(.......((........))...........(((((............(...((((..........))))..............)........(..(((...((((((.(....((((((.((....))....(((......)))...)))))).....((((.((((((.....(..(.(.....).))......))))))..(..(((((.....))))).....)..)))).....).).)))...)).))).).....))))).....)....)))))......((((.......(((..((...((......))...))....))).......)))).......(....((.((((........)))).))....).....))))).....(((((((.........)))))))......))...)))))..))).))..(.(..((.(.((((..((..(((((((.((((....((((((.((((..((....)).))))))))))...)))).)))))))..))..))))..).))...)..)...((((((.((...))))))).)}........... Molecular model of the cryo-EM structure of 70S ribosome in complex with peptide deformylase, trigger factor, and methionine aminopeptidase; 16S ribosomal RNA 7d80 X 65 4.1 RF00005 URS00021ED932_562 33761323 0030533 0006412 562 gggugauagcucaggggagagcaccucccuacaggaggggucggcggcgaucccgucaucaccca .<<..<..<<.<......>.>>.<<<<<.....>>>>>....<<...........>>.>..>>.. ..(.(.....(........).....((.......))......(.............)..)...). Molecular model of the cryo-EM structure of 70S ribosome in complex with peptide deformylase, trigger factor, and methionine aminopeptidase; E-site tRNA 7d80 Z 66 4.1 RF00005 URS000021B2C1_562 33761323 0030533 0006412 562 gggucguagcucaggguagagcaguugacuuuacaauugcgcaggcgaauccugcacgacccacca <<<<<<<.<<<<......>>>>.<<<<......>>>>..................>>>>>>>.... ..((.((.(((........)))...(........).....(.............))).).)..... Molecular model of the cryo-EM structure of 70S ribosome in complex with peptide deformylase, trigger factor, and methionine aminopeptidase; A-site tRNA 7d80 a 118 4.1 RF00001 URS0000366A67_562 33761323 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (((((((((.....((((((((....(((.(((...(.....)...)))...)))...)))))).)).((.......(.((((((...)))))).).......))...))))))))). Molecular model of the cryo-EM structure of 70S ribosome in complex with peptide deformylase, trigger factor, and methionine aminopeptidase; 5S ribosomal RNA 7d80 y 70 4.1 RF00005 URS000009EE82_562 33761323 0030533 0006412 562 ggagcggaguucagucgguuagaauaccugccuuccgcaggggucgcgggcgagucccgccguuccgcca <<<<<<<.<<<<.........>>>>.<<<<<.....>>>>>.....<<<<.....>>>>>>>>>>>.... .((.(((..(.(.........).)..(((((.....)))))......(((.....))).))).))..... Molecular model of the cryo-EM structure of 70S ribosome in complex with peptide deformylase, trigger factor, and methionine aminopeptidase; P-site tRNA 7d8c B 38 3.6 URS00023119B5_1410628 34108490 1410628 auuuuugugcccaucguuggcacuauuaaggaauggaa ......<<<<<.......>>>>>............... ......((((((...)..)))))............... Crystal structure of the Cas12i1-crRNA binary complex; RNA (38-MER) 7dco B 179 2.5 RF00020 URS000053F313_4932 33243853 0000244,0000353 0005682,0046540 4932 aagcagcuuuacagaucaauggcggagggaggucaacaucaagaacugugggccuuugccuauagaacuuauaacgaacaugguucuugccuuuuaccagaaccauccggguguugucuccauagaaacagguaaagcuguccguuacugugggcuugccauauuuuuuggaacuuuuc ...<<<<<<.<<<<.......<<<<..<<<<<.<<<<<<<.....<<<<<<<<....>>>>>>>>..............<<<<<<<<...........>>>>>>>>...>>>>>>>>>>>>......<<<<......>>>>>>>>..>>>>>>>>.>>..................... ...((((.(.((((........(((..(((((.(((((((.....((((((((....)))))))).........((...((((((((.(.......).)))))))).))))))))))))))......((((......)))))))...))))).)).))..................... Cryo-EM structure of the activated spliceosome (Bact complex) at an atomic resolution of 2.5 angstrom; U5 snRNA 7dco F 103 2.5 RF00026 URS00006184A9_4932 33243853 0030621 0000244,0000353 0005688,0046540 4932 guucgcgaaguaacccuucguggacauuuggucaauuugaaacaauacagagaugaucagcaguuccccugcauaaggaugaaccguuuuacaaagagauuua <<<<<<<<<<.....>>>>>>>>>>.....................................<<<..<<<.....>>>...>>>................... ((((((((((.....))))))))))......................................((.((((.....)))..))).................... Cryo-EM structure of the activated spliceosome (Bact complex) at an atomic resolution of 2.5 angstrom; U6 snRNA 7dco G 105 2.5 33243853 4932 aaaauaaaaaaaaaaaaauuuguaagguauguauuauuuuuuaaaaaaaaaaaaaaaaaaacuagauacuaacacauuuaauuuuuuuuuguuuuuuuuuuuuuu ......................................................................................................... ......................................................................................................... Cryo-EM structure of the activated spliceosome (Bact complex) at an atomic resolution of 2.5 angstrom; pre-mRNA 7dco H 169 2.5 RF00004 URS0000D77944_4932 33243853 0045131 0000348 0005686 4932 acgaaucucuuugccuuuuggcuuagaucaaguguaguaucuguucuuuucaguguaacaacugaaaugaccuaggcucauacauuuuuuggcacggacgggaagaggagacgucgcgacccucggagucguucuugacuuggucgcuugauguuucuucuucccguuc ................................................<<<<<<......>>>>>><<<<<<..>>.>>>>...............<<<<<<<<<<...<<<<<<<<<<.<<...<<<<<<....>>>>>>>>>>>>..>>>>>>...>>>>>>>>>>. .................................................(((((......)))))..((.((()))..))...................(((.(((.(..((((.((((.((....(((((....))))).))))))...))))...))).)))).... Cryo-EM structure of the activated spliceosome (Bact complex) at an atomic resolution of 2.5 angstrom; U2 snRNA 7dfg P 12 2.7 URS00023119C8_2697049 2697049 agauuaaguuau ............ ............ Structure of COVID-19 RNA-dependent RNA polymerase bound to favipiravir; RNA (5'-R(P*AP*GP*AP*UP*UP*AP*AP*GP*UP*UP*AP*U)-3') 7dfg T 16 2.7 URS0002311A02_2697049 2697049 cccuauaacuuaaucu ................ ................ Structure of COVID-19 RNA-dependent RNA polymerase bound to favipiravir; RNA (5'-R(P*CP*CP*CP*UP*AP*UP*AP*AP*CP*UP*UP*AP*AP*UP*CP*U)-3') 7dfh T 12 2.97 URS0002311980_2697049 2697049 cccccacauagc ............ ............ Structure of COVID-19 RNA-dependent RNA polymerase bound to ribavirin; RNA (5'-R(P*CP*CP*CP*CP*CP*AP*CP*AP*UP*AP*GP*C)-3') 7dmq B 53 3.06 URS00021ED93F_157691 33472057 157691 accccaauaucgaaggggacuaaaacuagauugcuguucuaccaaguaaucca .<<<<.........>>>>................................... .((((.........))))................................... Cryo-EM structure of LshCas13a-crRNA-anti-tag RNA complex; CRISPR RNA 7dmq C 35 3.06 URS00021ED911_562 33472057 562 uggauuacuugguagaacagcaaucuaguuuuagu ................................... ................................... Cryo-EM structure of LshCas13a-crRNA-anti-tag RNA complex; Anti-tag target RNA 7doi P 12 2.6 URS00023119C8_2697049 2697049 agauuaaguuau ............ ............ Structure of COVID-19 RNA-dependent RNA polymerase bound to penciclovir.; RNA (5'-R(P*AP*GP*AP*UP*UP*AP*AP*GP*UP*UP*AP*U)-3') 7doi T 15 2.6 URS00023119C7_2697049 2697049 ccuauaacuuaaucu ............... ............... Structure of COVID-19 RNA-dependent RNA polymerase bound to penciclovir.; RNA (5'-R(P*CP*CP*UP*AP*UP*AP*AP*CP*UP*UP*AP*AP*UP*CP*U)-3') 7dok P 20 2.73 URS0001A16A67_2697049 2697049 gcuaugugagauuaaguuau .................... .................... Structure of COVID-19 RNA-dependent RNA polymerase (extended conformation) bound to penciclovir; RNA (5'-R(P*GP*CP*UP*AP*UP*GP*UP*GP*AP*GP*AP*UP*UP*AP*AP*GP*UP*UP*AP*U)-3') 7dok T 24 2.73 URS0002311990_2697049 2697049 cccuauaacuuaaucucacauagc ........................ ........................ Structure of COVID-19 RNA-dependent RNA polymerase (extended conformation) bound to penciclovir; RNA (5'-R(P*CP*CP*CP*UP*AP*UP*AP*AP*CP*UP*UP*AP*AP*UP*CP*UP*CP*AP*CP*AP*UP*AP*GP*C)-3') 7dte F 33 3.0 URS00023119EE_12110 34653416 12110 cuccugugucgucgaacaucgucgaacaucguc ................................. ................................. SARS-CoV-2 RdRP catalytic complex with T33-1 RNA; RNA (57-MER) 7dte G 29 3.0 URS000231197E_12110 34653416 12110 gacgauguucgacgauguucgacgacaca ............................. ............................. SARS-CoV-2 RdRP catalytic complex with T33-1 RNA; RNA (33-MER) 7dug A 1512 3.75 RF00177,RF01959,RF01960 URS000080DD5E_300852 0003735 0005840 300852 uggagagucugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauccuuucu ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<.......>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<<....>>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<<..>>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>........... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.....)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..((((((((....((((((((....((((((....((........)).......))))))....).......((....)).)))))))...)))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((.(....(((((....))))).....((((....))))...)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...(....((.....)).).....)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((.((((((...(.((((....(((....))).)))).)..)))))).))))))..))).))))..).))...)..)..(((((((((....)))))))))}.......... Crystal structure of the Thermus thermophilus (HB8) 30S ribosomal subunit with mRNA and cognate transfer RNA anticodon stem-loop and sisomicin derivative N1''TFMS bound; 30S Ribosomal RNA rRNA 7dug W 15 3.75 URS000080E1F5_274 274 gggauugaaaauccc <<<<<.....>>>>> .(((.......))). Crystal structure of the Thermus thermophilus (HB8) 30S ribosomal subunit with mRNA and cognate transfer RNA anticodon stem-loop and sisomicin derivative N1''TFMS bound; RNA (5'-R(*GP*GP*GP*AP*UP*UP*GP*AP*AP*AP*AP*UP*CP*CP*C)-3') 7duh A 1512 3.75 RF00177,RF01959,RF01960 URS000080DD5E_300852 0003735 0005840 300852 uggagagucugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauccuuucu ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<...<..<<<.<<<..<<<..<<.<<<<<<<<<.......>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>...>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<.<<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<.<..<<<<<<<....>>>>>>>...<<<<....>>>>..>.>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<<..>>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>........... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.....)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..((((((((....((((((((....((((((....((........)).......))))))....).......((....)).)))))))...)))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((.(.(....(((((....)))))......(((....)))....)).))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...(...(((.....)))).....))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((.((((((...(.((((....(((....))).)))).)..)))))).))))))..))).))))..).))...)..)..(((((((((....)))))))))}.......... Crystal structure of the Thermus thermophilus (HB8) 30S ribosomal subunit with mRNA and cognate transfer RNA anticodon stem-loop and sisomicin derivative N1''AC bound; 30S Ribosomal RNA rRNA 7duh W 15 3.75 URS000080E1F5_274 274 gggauugaaaauccc <<<<<.....>>>>> .(((.......))). Crystal structure of the Thermus thermophilus (HB8) 30S ribosomal subunit with mRNA and cognate transfer RNA anticodon stem-loop and sisomicin derivative N1''AC bound; RNA (5'-R(*GP*GP*GP*AP*UP*UP*GP*AP*AP*AP*AP*UP*CP*CP*C)-3') 7dui A 1512 3.62 RF00177,RF01959,RF01960 URS000080DD5E_300852 0003735 0005840 300852 uggagagucugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauccuuucu ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<.......>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<.<..<<<<<<<....>>>>>>>...<<<<....>>>>..>.>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>........... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.....)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..((((((((....((((((((....((((((....((........)).......))))))....).......((....)).)))))))...)))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((.(....(((((....))))).....((((....))))...)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...(....((.....)).).....))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((.((((((...(.((((....(((....))).)))).)..)))))).))))))..))).))))..).))...)..)..(((((((((....)))))))))}.......... Crystal structure of the Thermus thermophilus (HB8) 30S ribosomal subunit with mRNA and cognate transfer RNA anticodon stem-loop and sisomicin derivative N1''PyrS bound; 30S Ribosomal RNA rRNA 7dui W 15 3.62 URS000080E1F5_274 274 gggauugaaaauccc <<<<<.....>>>>> .(((.......))). Crystal structure of the Thermus thermophilus (HB8) 30S ribosomal subunit with mRNA and cognate transfer RNA anticodon stem-loop and sisomicin derivative N1''PyrS bound; RNA (5'-R(*GP*GP*GP*AP*UP*UP*GP*AP*AP*AP*AP*UP*CP*CP*C)-3') 7duj A 1512 3.75 RF00177,RF01959,RF01960 URS000080DD5E_300852 0003735 0005840 300852 uggagagucugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauccuuucu ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<.......>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<((....<<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<.<<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<<....>>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>........... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.....)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..((((((((....((((((((....((((((....((........)).......))))))....).......((....)).)))))))...)))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((.(....(((((....))))).....((((....))))...)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...(....((.....)).).....)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((.((((((...(.((((....(((....))).)))).)..)))))).))))))..))).))))..).))...)..)..(((((((((....)))))))))}.......... Crystal structure of the Thermus thermophilus (HB8) 30S ribosomal subunit with mRNA and cognate transfer RNA anticodon stem-loop and sisomicin derivative N1,3''Bz bound; 30S Ribosomal RNA rRNA 7duj W 15 3.75 URS000080E1F5_274 274 gggauugaaaauccc <<<<<.....>>>>> .(((.......))). Crystal structure of the Thermus thermophilus (HB8) 30S ribosomal subunit with mRNA and cognate transfer RNA anticodon stem-loop and sisomicin derivative N1,3''Bz bound; RNA (5'-R(*GP*GP*GP*AP*UP*UP*GP*AP*AP*AP*AP*UP*CP*CP*C)-3') 7duk A 1512 3.6 RF00177,RF01959,RF01960 URS000080DD5E_300852 0003735 0005840 300852 uggagagucugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauccuuucu ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<.......>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<.<..<<<<<<<....>>>>>>>...<<<<....>>>>..>.>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<<..>>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>........... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.....)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..((((((((....((((((((....((((((....((........)).......))))))....).......((....)).)))))))...)))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((.(.....((((....)))).......(((....)))....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...(....((.....)).).....))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((.((((((...(.((((....(((....))).)))).)..)))))).))))))..))).))))..).))...)..)..(((((((((....)))))))))}.......... Crystal structure of the Thermus thermophilus (HB8) 30S ribosomal subunit with mRNA and cognate transfer RNA anticodon stem-loop and sisomicin derivative N1,3''MS bound; 30S Ribosomal RNA rRNA 7duk W 15 3.6 URS000080E1F5_274 274 gggauugaaaauccc <<<<<.....>>>>> .(((.......))). Crystal structure of the Thermus thermophilus (HB8) 30S ribosomal subunit with mRNA and cognate transfer RNA anticodon stem-loop and sisomicin derivative N1,3''MS bound; RNA (5'-R(*GP*GP*GP*AP*UP*UP*GP*AP*AP*AP*AP*UP*CP*CP*C)-3') 7dul A 1512 3.62 RF00177,RF01959,RF01960 URS000080DD5E_300852 0003735 0005840 300852 uggagagucugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauccuuucu ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<.......>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<.<..<<<<<<<....>>>>>>>...<<<<....>>>>..>.>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<<..>>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>........... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.....)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..((((((((....((((((((....((((((....((........)).......))))))....).......((....)).)))))))...)))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((.((.....((((....))))......((((....))))...)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...(....((.....)).).....))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((.((((((...(.((((....(((....))).)))).)..)))))).))))))..))).))))..).))...)..)..(((((((((....)))))))))}.......... Crystal structure of the Thermus thermophilus (HB8) 30S ribosomal subunit with mRNA and cognate transfer RNA anticodon stem-loop and sisomicin derivative N3''MS bound; 30S Ribosomal RNA rRNA 7dul W 15 3.62 URS000080E1F5_274 274 gggauugaaaauccc <<<<<.....>>>>> .(((.......))). Crystal structure of the Thermus thermophilus (HB8) 30S ribosomal subunit with mRNA and cognate transfer RNA anticodon stem-loop and sisomicin derivative N3''MS bound; RNA (5'-R(*GP*GP*GP*AP*UP*UP*GP*AP*AP*AP*AP*UP*CP*CP*C)-3') 7dvq B 90 2.89 RF00020 URS000075BAAE_9606 33509932 0000244,0000353 0005682,0046540 9606 gguuucucuucagaucgcauaaaucuuucgccuuuuacuaaagauuuccguggagaggaacaacccaauuuuuugaggccuugcaaggcu .<<<<<<<<<<<........<<<<<<<<...........>>>>>>>>...>>>>>>>>>>>...............<<<<<<..>>>>>> .(((((((((((...((...((((((((.(.......).)))))))).)))))))))))))...............((((((())))))) Cryo-EM Structure of the Activated Human Minor Spliceosome (minor Bact Complex); U5 snRNA 7dvq F 60 2.89 RF00619 URS00021ED9B2_9606 33509932 0030622,0030627 0000244,0000395 0005691 9606 uguuguaugaaaggagagaagguuagcacuccccuugacaaggauggaagaggccggccu ............................<<<<<<<<...>>>>..>>>.><<<<<>>>>> ............................(((((((.....)))..))).)((((())))) Cryo-EM Structure of the Activated Human Minor Spliceosome (minor Bact Complex); U6atac snRNA 7dvq G 63 2.89 33509932 9606 ucggccuccgaaauauccuuuucuagcaugugucauauccuuaacucauugucccuuuuuuuu ............................................................... ............................................................... Cryo-EM Structure of the Activated Human Minor Spliceosome (minor Bact Complex); pre-mRNA 7dvq H 63 2.89 RF00007 URS00006ECA78_9606 33509932 0045131 0000348 0005693 9606 augccuuaaacuuaugaguaaggaaaauaacgauucggggugacgcccgaagaauuuuugagc .................................<<<<<<......>>>>>>............ .................................((((((......))))))............ Cryo-EM Structure of the Activated Human Minor Spliceosome (minor Bact Complex); U12 snRNA 7eag C 19 2.5 URS000231196D_289380 33978763 289380 gucuaugaaggcuggagac ................... ................... Crystal structure of the RAGATH-18 k-turn; RNA (5'-R(*GP*UP*CP*UP*AP*UP*GP*AP*AP*GP*GP*CP*UP*GP*GP*AP*GP*AP*C)-3') 7eag D 19 2.5 URS000231196D_289380 33978763 289380 gucuaugaaggcuggagac ................... ................... Crystal structure of the RAGATH-18 k-turn; RNA (5'-R(*GP*UP*CP*UP*AP*UP*GP*AP*AP*GP*GP*CP*UP*GP*GP*AP*GP*AP*C)-3') 7eag A 11 2.5 URS000231196D_289380 33978763 289380 gucuaugaagg ........... ........... Crystal structure of the RAGATH-18 k-turn; RNA (5'-R(*GP*UP*CP*UP*AP*UP*GP*AP*AP*GP*GP*CP*UP*GP*GP*AP*GP*AP*C)-3') 7eag E 19 2.5 URS000231196D_289380 33978763 289380 gucuaugaaggcuggagac ................... ................... Crystal structure of the RAGATH-18 k-turn; RNA (5'-R(*GP*UP*CP*UP*AP*UP*GP*AP*AP*GP*GP*CP*UP*GP*GP*AP*GP*AP*C)-3') 7eag F 19 2.5 URS000231196D_289380 33978763 289380 gucuaugaaggcuggagac ................... ................... Crystal structure of the RAGATH-18 k-turn; RNA (5'-R(*GP*UP*CP*UP*AP*UP*GP*AP*AP*GP*GP*CP*UP*GP*GP*AP*GP*AP*C)-3') 7ecj A 12 3.1 URS00023358B6_32630 32630 ggacungaaucc ............ ............ RNA duplex containing C-A base pairs; DNA/RNA (5'-R(*GP*GP*AP*CP*U)-D(P*(CBR))-R(P*GP*AP*AP*UP*CP*C)-3') 7ecj B 12 3.1 URS00023358B6_32630 32630 ggacungaaucc ............ ............ RNA duplex containing C-A base pairs; DNA/RNA (5'-R(*GP*GP*AP*CP*U)-D(P*(CBR))-R(P*GP*AP*AP*UP*CP*C)-3') 7ecj C 12 3.1 URS00023358B6_32630 32630 ggacungaaucc ............ ............ RNA duplex containing C-A base pairs; DNA/RNA (5'-R(*GP*GP*AP*CP*U)-D(P*(CBR))-R(P*GP*AP*AP*UP*CP*C)-3') 7eck A 12 2.79 URS00023358B6_32630 32630 ggacungaaucc ............ ............ RNA duplex containing C-Ag-A and U-Ag-A base pairs; DNA/RNA (5'-R(*GP*GP*AP*CP*U)-D(P*(CBR))-R(P*GP*AP*AP*UP*CP*C)-3') 7eck B 12 2.79 URS00023358B6_32630 32630 ggacungaaucc ............ ............ RNA duplex containing C-Ag-A and U-Ag-A base pairs; DNA/RNA (5'-R(*GP*GP*AP*CP*U)-D(P*(CBR))-R(P*GP*AP*AP*UP*CP*C)-3') 7eck C 12 2.79 URS00023358B6_32630 32630 ggacungaaucc ............ ............ RNA duplex containing C-Ag-A and U-Ag-A base pairs; DNA/RNA (5'-R(*GP*GP*AP*CP*U)-D(P*(CBR))-R(P*GP*AP*AP*UP*CP*C)-3') 7eck D 12 2.79 URS00023358B6_32630 32630 ggacungaaucc ............ ............ RNA duplex containing C-Ag-A and U-Ag-A base pairs; DNA/RNA (5'-R(*GP*GP*AP*CP*U)-D(P*(CBR))-R(P*GP*AP*AP*UP*CP*C)-3') 7eck E 12 2.79 URS00023358B6_32630 32630 ggacungaaucc ............ ............ RNA duplex containing C-Ag-A and U-Ag-A base pairs; DNA/RNA (5'-R(*GP*GP*AP*CP*U)-D(P*(CBR))-R(P*GP*AP*AP*UP*CP*C)-3') 7eck F 12 2.79 URS00023358B6_32630 32630 ggacungaaucc ............ ............ RNA duplex containing C-Ag-A and U-Ag-A base pairs; DNA/RNA (5'-R(*GP*GP*AP*CP*U)-D(P*(CBR))-R(P*GP*AP*AP*UP*CP*C)-3') 7eck G 12 2.79 URS00023358B6_32630 32630 ggacungaaucc ............ ............ RNA duplex containing C-Ag-A and U-Ag-A base pairs; DNA/RNA (5'-R(*GP*GP*AP*CP*U)-D(P*(CBR))-R(P*GP*AP*AP*UP*CP*C)-3') 7eck H 12 2.79 URS00023358B6_32630 32630 ggacungaaucc ............ ............ RNA duplex containing C-Ag-A and U-Ag-A base pairs; DNA/RNA (5'-R(*GP*GP*AP*CP*U)-D(P*(CBR))-R(P*GP*AP*AP*UP*CP*C)-3') 7eck I 12 2.79 URS00023358B6_32630 32630 ggacungaaucc ............ ............ RNA duplex containing C-Ag-A and U-Ag-A base pairs; DNA/RNA (5'-R(*GP*GP*AP*CP*U)-D(P*(CBR))-R(P*GP*AP*AP*UP*CP*C)-3') 7eck J 12 2.79 URS00023358B6_32630 32630 ggacungaaucc ............ ............ RNA duplex containing C-Ag-A and U-Ag-A base pairs; DNA/RNA (5'-R(*GP*GP*AP*CP*U)-D(P*(CBR))-R(P*GP*AP*AP*UP*CP*C)-3') 7eck K 12 2.79 URS00023358B6_32630 32630 ggacungaaucc ............ ............ RNA duplex containing C-Ag-A and U-Ag-A base pairs; DNA/RNA (5'-R(*GP*GP*AP*CP*U)-D(P*(CBR))-R(P*GP*AP*AP*UP*CP*C)-3') 7eck L 12 2.79 URS00023358B6_32630 32630 ggacungaaucc ............ ............ RNA duplex containing C-Ag-A and U-Ag-A base pairs; DNA/RNA (5'-R(*GP*GP*AP*CP*U)-D(P*(CBR))-R(P*GP*AP*AP*UP*CP*C)-3') 7ecl A 12 3.01 URS00023358B6_32630 32630 ggacungaaucc ............ ............ RNA duplex containing C-Ag-A and U-Ag-A base pair; DNA/RNA (5'-R(*GP*GP*AP*CP*U)-D(P*(CBR))-R(P*GP*AP*AP*UP*CP*C)-3') 7ecl B 12 3.01 URS00023358B6_32630 32630 ggacungaaucc ............ ............ RNA duplex containing C-Ag-A and U-Ag-A base pair; DNA/RNA (5'-R(*GP*GP*AP*CP*U)-D(P*(CBR))-R(P*GP*AP*AP*UP*CP*C)-3') 7ecl C 12 3.01 URS00023358B6_32630 32630 ggacungaaucc ............ ............ RNA duplex containing C-Ag-A and U-Ag-A base pair; DNA/RNA (5'-R(*GP*GP*AP*CP*U)-D(P*(CBR))-R(P*GP*AP*AP*UP*CP*C)-3') 7ecl D 12 3.01 URS00023358B6_32630 32630 ggacungaaucc ............ ............ RNA duplex containing C-Ag-A and U-Ag-A base pair; DNA/RNA (5'-R(*GP*GP*AP*CP*U)-D(P*(CBR))-R(P*GP*AP*AP*UP*CP*C)-3') 7ecl E 12 3.01 URS00023358B6_32630 32630 ggacungaaucc ............ ............ RNA duplex containing C-Ag-A and U-Ag-A base pair; DNA/RNA (5'-R(*GP*GP*AP*CP*U)-D(P*(CBR))-R(P*GP*AP*AP*UP*CP*C)-3') 7ecl F 12 3.01 URS00023358B6_32630 32630 ggacungaaucc ............ ............ RNA duplex containing C-Ag-A and U-Ag-A base pair; DNA/RNA (5'-R(*GP*GP*AP*CP*U)-D(P*(CBR))-R(P*GP*AP*AP*UP*CP*C)-3') 7ecl G 12 3.01 URS00023358B6_32630 32630 ggacungaaucc ............ ............ RNA duplex containing C-Ag-A and U-Ag-A base pair; DNA/RNA (5'-R(*GP*GP*AP*CP*U)-D(P*(CBR))-R(P*GP*AP*AP*UP*CP*C)-3') 7ecl H 12 3.01 URS00023358B6_32630 32630 ggacungaaucc ............ ............ RNA duplex containing C-Ag-A and U-Ag-A base pair; DNA/RNA (5'-R(*GP*GP*AP*CP*U)-D(P*(CBR))-R(P*GP*AP*AP*UP*CP*C)-3') 7ecl I 12 3.01 URS00023358B6_32630 32630 ggacungaaucc ............ ............ RNA duplex containing C-Ag-A and U-Ag-A base pair; DNA/RNA (5'-R(*GP*GP*AP*CP*U)-D(P*(CBR))-R(P*GP*AP*AP*UP*CP*C)-3') 7ecl J 12 3.01 URS00023358B6_32630 32630 ggacungaaucc ............ ............ RNA duplex containing C-Ag-A and U-Ag-A base pair; DNA/RNA (5'-R(*GP*GP*AP*CP*U)-D(P*(CBR))-R(P*GP*AP*AP*UP*CP*C)-3') 7ecl K 12 3.01 URS00023358B6_32630 32630 ggacungaaucc ............ ............ RNA duplex containing C-Ag-A and U-Ag-A base pair; DNA/RNA (5'-R(*GP*GP*AP*CP*U)-D(P*(CBR))-R(P*GP*AP*AP*UP*CP*C)-3') 7ecl L 12 3.01 URS00023358B6_32630 32630 ggacungaaucc ............ ............ RNA duplex containing C-Ag-A and U-Ag-A base pair; DNA/RNA (5'-R(*GP*GP*AP*CP*U)-D(P*(CBR))-R(P*GP*AP*AP*UP*CP*C)-3') 7ecm A 12 1.51 URS00023358FB_32630 32630 gggcccggaccc ............ ............ RNA duplex containing C-A base pair; RNA (5'-R(*GP*GP*GP*CP*CP*CP*GP*GP*AP*CP*CP*C)-3') 7ecm B 12 1.51 URS00023358FB_32630 32630 gggcccggaccc ............ ............ RNA duplex containing C-A base pair; RNA (5'-R(*GP*GP*GP*CP*CP*CP*GP*GP*AP*CP*CP*C)-3') 7ecm C 12 1.51 URS00023358FB_32630 32630 gggcccggaccc ............ ............ RNA duplex containing C-A base pair; RNA (5'-R(*GP*GP*GP*CP*CP*CP*GP*GP*AP*CP*CP*C)-3') 7ecm D 12 1.51 URS00023358FB_32630 32630 gggcccggaccc ............ ............ RNA duplex containing C-A base pair; RNA (5'-R(*GP*GP*GP*CP*CP*CP*GP*GP*AP*CP*CP*C)-3') 7ecn A 12 1.6 URS00023358FB_32630 32630 gggcccggaccc ............ ............ RNA duplex containing C-Ag-A base pairs; RNA (5'-R(*GP*GP*GP*CP*CP*CP*GP*GP*AP*CP*CP*C)-3') 7ecn B 12 1.6 URS00023358FB_32630 32630 gggcccggaccc ............ ............ RNA duplex containing C-Ag-A base pairs; RNA (5'-R(*GP*GP*GP*CP*CP*CP*GP*GP*AP*CP*CP*C)-3') 7ecn C 12 1.6 URS00023358FB_32630 32630 gggcccggaccc ............ ............ RNA duplex containing C-Ag-A base pairs; RNA (5'-R(*GP*GP*GP*CP*CP*CP*GP*GP*AP*CP*CP*C)-3') 7ecn D 12 1.6 URS00023358FB_32630 32630 gggcccggaccc ............ ............ RNA duplex containing C-Ag-A base pairs; RNA (5'-R(*GP*GP*GP*CP*CP*CP*GP*GP*AP*CP*CP*C)-3') 7eco E 12 1.81 URS00023358BA_32630 32630 ggguccgguccc ............ ............ RNA duplex containing U-Ag-U base pairs; RNA (5'-R(*GP*GP*GP*UP*CP*CP*GP*GP*UP*CP*CP*C)-3') 7eco F 12 1.81 URS00023358BA_32630 32630 ggguccgguccc ............ ............ RNA duplex containing U-Ag-U base pairs; RNA (5'-R(*GP*GP*GP*UP*CP*CP*GP*GP*UP*CP*CP*C)-3') 7eco A 12 1.81 URS00023358BA_32630 32630 ggguccgguccc ............ ............ RNA duplex containing U-Ag-U base pairs; RNA (5'-R(*GP*GP*GP*UP*CP*CP*GP*GP*UP*CP*CP*C)-3') 7eco B 12 1.81 URS00023358BA_32630 32630 ggguccgguccc ............ ............ RNA duplex containing U-Ag-U base pairs; RNA (5'-R(*GP*GP*GP*UP*CP*CP*GP*GP*UP*CP*CP*C)-3') 7eco C 12 1.81 URS00023358BA_32630 32630 ggguccgguccc ............ ............ RNA duplex containing U-Ag-U base pairs; RNA (5'-R(*GP*GP*GP*UP*CP*CP*GP*GP*UP*CP*CP*C)-3') 7eco D 12 1.81 URS00023358BA_32630 32630 ggguccgguccc ............ ............ RNA duplex containing U-Ag-U base pairs; RNA (5'-R(*GP*GP*GP*UP*CP*CP*GP*GP*UP*CP*CP*C)-3') 7ecp A 12 2.91 URS00023358F4_32630 32630 gggcccgguccc ............ ............ RNA duplex containing C-Ag-U; RNA (5'-R(*GP*GP*GP*CP*CP*CP*GP*GP*UP*CP*CP*C)-3') 7ecp B 12 2.91 URS00023358F4_32630 32630 gggcccgguccc ............ ............ RNA duplex containing C-Ag-U; RNA (5'-R(*GP*GP*GP*CP*CP*CP*GP*GP*UP*CP*CP*C)-3') 7ecp C 12 2.91 URS00023358F4_32630 32630 gggcccgguccc ............ ............ RNA duplex containing C-Ag-U; RNA (5'-R(*GP*GP*GP*CP*CP*CP*GP*GP*UP*CP*CP*C)-3') 7ecp D 12 2.91 URS00023358F4_32630 32630 gggcccgguccc ............ ............ RNA duplex containing C-Ag-U; RNA (5'-R(*GP*GP*GP*CP*CP*CP*GP*GP*UP*CP*CP*C)-3') 7ed5 I 20 2.98 URS0001A16A67_32630 35110538 32630 gcuaugugagauuaaguuau .................... .................... A dual mechanism of action of AT-527 against SARS-CoV-2 polymerase; RNA (5'-R(P*GP*CP*UP*AP*UP*GP*UP*GP*AP*GP*AP*UP*UP*AP*AP*GP*UP*UP*AP*U*(AT9))-3') 7ed5 J 24 2.98 URS00023358E0_32630 35110538 32630 ccccauaacuuaaucucacauagc ........................ ........................ A dual mechanism of action of AT-527 against SARS-CoV-2 polymerase; RNA (5'-R(P*CP*CP*CP*CP*AP*UP*AP*AP*CP*UP*UP*AP*AP*UP*CP*UP*CP*AP*CP*AP*UP*AP*GP*C)-3') 7edl A 22 2.6 URS000080DDE4_32630 32630 ugcgucacgccggcgaagucgc ...................... ...................... Crystal structure of the bacterial ribosomal decoding site in complex with G418 and Hg(II); RNA (5'-R(P*UP*GP*CP*GP*UP*CP*AP*CP*GP*CP*CP*GP*GP*CP*GP*AP*AP*GP*UP*CP*GP*C)-3') 7edl B 21 2.6 URS000080DDE4_32630 32630 gcgucacgccggcgaagucgc ..................... ..................... Crystal structure of the bacterial ribosomal decoding site in complex with G418 and Hg(II); RNA (5'-R(P*UP*GP*CP*GP*UP*CP*AP*CP*GP*CP*CP*GP*GP*CP*GP*AP*AP*GP*UP*CP*GP*C)-3') 7edm A 22 2.81 URS000080E022_32630 32630 ugcgucgcgucgacgaagucgc ...................... ...................... Crystal structure of the eukaryotic ribosomal decoding site in complex with G418 and Hg(II); RNA (5'-R(P*UP*GP*CP*GP*UP*CP*GP*CP*GP*UP*CP*GP*AP*CP*GP*AP*AP*GP*UP*CP*GP*C)-3') 7edm B 21 2.81 URS000080E022_32630 32630 gcgucgcgucgacgaagucgc ..................... ..................... Crystal structure of the eukaryotic ribosomal decoding site in complex with G418 and Hg(II); RNA (5'-R(P*UP*GP*CP*GP*UP*CP*GP*CP*GP*UP*CP*GP*AP*CP*GP*AP*AP*GP*UP*CP*GP*C)-3') 7edn A 22 2.6 URS000080E022_32630 32630 ugcgucgcgucgacgaagucgc ...................... ...................... Crystal structure of the eukaryotic decoding site in complex with Ag(I); RNA (5'-R(P*UP*GP*CP*GP*UP*CP*GP*CP*GP*UP*CP*GP*AP*CP*GP*AP*AP*GP*UP*CP*GP*C)-3') 7edt A 12 1.2 URS0002335907_32630 32630 ggacuccggncc ............ ............ RNA duplex containing CC mispairs; RNA (5'-R(*GP*GP*AP*CP*UP*CP*CP*GP*GP*(5BU)P*CP*C)-3') 7edt B 12 1.2 URS0002335907_32630 32630 ggacuccggncc ............ ............ RNA duplex containing CC mispairs; RNA (5'-R(*GP*GP*AP*CP*UP*CP*CP*GP*GP*(5BU)P*CP*C)-3') 7edu A 12 2.3 URS00008E394B_32630 32630 ggacucgacucc ............ ............ RNA duplex containing C-Au-C base pair; RNA (5'-R(*GP*GP*AP*CP*UP*CP*GP*AP*CP*UP*CP*C)-3') 7edu B 12 2.3 URS00008E394B_32630 32630 ggacucgacucc ............ ............ RNA duplex containing C-Au-C base pair; RNA (5'-R(*GP*GP*AP*CP*UP*CP*GP*AP*CP*UP*CP*C)-3') 7edu C 12 2.3 URS00008E394B_32630 32630 ggacucgacucc ............ ............ RNA duplex containing C-Au-C base pair; RNA (5'-R(*GP*GP*AP*CP*UP*CP*GP*AP*CP*UP*CP*C)-3') 7edu D 12 2.3 URS00008E394B_32630 32630 ggacucgacucc ............ ............ RNA duplex containing C-Au-C base pair; RNA (5'-R(*GP*GP*AP*CP*UP*CP*GP*AP*CP*UP*CP*C)-3') 7efg A 19 2.6 URS000080E16F_32630 32630 ggcgaagaaccggggagcc ................... ................... RNA kink-turn motif; RNA (5'-R(*GP*GP*CP*GP*AP*AP*GP*AP*AP*CP*CP*GP*GP*GP*GP*AP*GP*CP*C)-3') 7efh A 19 2.7 URS000080E16F_32630 32630 ggcgaagaaccggggagcc ................... ................... RNA kink-turn motif; RNA (5'-R(*GP*GP*CP*GP*AP*AP*GP*AP*AP*CP*CP*GP*GP*GP*GP*AP*GP*CP*C)-3') 7efi A 19 2.9 32630 ggcgaagaaccnnngagnn ................... ................... RNA kink-turn motif composed of RNA, DNA and 2'-O-methyl RNA; DNA/RNA (5'-R(*GP*GP*CP*GP*AP*AP*GP*AP*AP*CP*CP*(OMG)P*(OMG)P*(OMG))-D(P*GP*A)-R(P*GP*(OMC)P*(OMC))-3') 7egq I 25 3.35 URS00021ED98C_2697049 34143953 2697049 gcgguaguagcaugcuagggagcag ......................... ......................... Co-transcriptional capping machineries in SARS-CoV-2 RTC: Coupling of N7-methyltransferase and 3'-5' exoribonuclease with polymerase reveals mechanisms for capping and proofreading; primer RNA 7egq J 33 3.35 URS0002311969_2697049 34143953 2697049 aaugucugacugcucccuagcaugcuacuaccg ................................. ................................. Co-transcriptional capping machineries in SARS-CoV-2 RTC: Coupling of N7-methyltransferase and 3'-5' exoribonuclease with polymerase reveals mechanisms for capping and proofreading; Template RNA 7egq L 25 3.35 URS00021ED98C_2697049 34143953 2697049 gcgguaguagcaugcuagggagcag ......................... ......................... Co-transcriptional capping machineries in SARS-CoV-2 RTC: Coupling of N7-methyltransferase and 3'-5' exoribonuclease with polymerase reveals mechanisms for capping and proofreading; primer RNA 7egq M 33 3.35 URS0002311969_2697049 34143953 2697049 aaugucugacugcucccuagcaugcuacuaccg ................................. ................................. Co-transcriptional capping machineries in SARS-CoV-2 RTC: Coupling of N7-methyltransferase and 3'-5' exoribonuclease with polymerase reveals mechanisms for capping and proofreading; Template RNA 7ei7 A 19 3.2 URS00023358D6_32630 32630 ggcgangaaccggggagcc ................... ................... RNA kink-turn motif with 2-aminopurine; RNA (5'-R(*GP*GP*CP*GP*A)-D(P*(2PR))-R(P*GP*AP*AP*CP*CP*GP*GP*GP*GP*AP*GP*CP*C)-3') 7ei7 B 19 3.2 URS00023358D6_32630 32630 ggcgangaaccggggagcc ................... ................... RNA kink-turn motif with 2-aminopurine; RNA (5'-R(*GP*GP*CP*GP*A)-D(P*(2PR))-R(P*GP*AP*AP*CP*CP*GP*GP*GP*GP*AP*GP*CP*C)-3') 7ei8 A 19 3.1 URS00023358B3_32630 32630 ggcnnnnaaccggggagcc ................... ................... RNA kink-turn motif with 2-aminopurine; RNA (5'-R(*GP*GP*C)-D(P*(2PR)P*(2PR)P*(2PR)P*(2PR))-R(P*AP*AP*CP*CP*GP*GP*GP*GP*AP*GP*CP*C)-3') 7ei8 B 19 3.1 URS00023358B3_32630 32630 ggcnnnnaaccggggagcc ................... ................... RNA kink-turn motif with 2-aminopurine; RNA (5'-R(*GP*GP*C)-D(P*(2PR)P*(2PR)P*(2PR)P*(2PR))-R(P*AP*AP*CP*CP*GP*GP*GP*GP*AP*GP*CP*C)-3') 7ei8 C 19 3.1 URS00023358B3_32630 32630 ggcnnnnaaccggggagcc ................... ................... RNA kink-turn motif with 2-aminopurine; RNA (5'-R(*GP*GP*C)-D(P*(2PR)P*(2PR)P*(2PR)P*(2PR))-R(P*AP*AP*CP*CP*GP*GP*GP*GP*AP*GP*CP*C)-3') 7ei8 D 19 3.1 URS00023358B3_32630 32630 ggcnnnnaaccggggagcc ................... ................... RNA kink-turn motif with 2-aminopurine; RNA (5'-R(*GP*GP*C)-D(P*(2PR)P*(2PR)P*(2PR)P*(2PR))-R(P*AP*AP*CP*CP*GP*GP*GP*GP*AP*GP*CP*C)-3') 7ei9 A 19 2.7 URS00023358B2_32630 32630 ggcgangaaccggggagcc ................... ................... RNA kink-turn motif with pyrrolo cytosine; RNA (5'-R(*GP*GP*CP*GP*A)-D(P*(4PC))-R(P*GP*AP*AP*CP*CP*GP*GP*GP*GP*AP*GP*CP*C)-3') 7ei9 B 19 2.7 URS00023358B2_32630 32630 ggcgangaaccggggagcc ................... ................... RNA kink-turn motif with pyrrolo cytosine; RNA (5'-R(*GP*GP*CP*GP*A)-D(P*(4PC))-R(P*GP*AP*AP*CP*CP*GP*GP*GP*GP*AP*GP*CP*C)-3') 7eia A 19 3.0 URS00023358B2_32630 32630 ggcgangaaccggggagcc ................... ................... RNA kink-turn motif with pyrrolo cytosine; RNA (5'-R(*GP*GP*CP*GP*A)-D(P*(4PC))-R(P*GP*AP*AP*CP*CP*GP*GP*GP*GP*AP*GP*CP*C)-3') 7eia B 19 3.0 URS00023358B2_32630 32630 ggcgangaaccggggagcc ................... ................... RNA kink-turn motif with pyrrolo cytosine; RNA (5'-R(*GP*GP*CP*GP*A)-D(P*(4PC))-R(P*GP*AP*AP*CP*CP*GP*GP*GP*GP*AP*GP*CP*C)-3') 7eia C 19 3.0 URS00023358B2_32630 32630 ggcgangaaccggggagcc ................... ................... RNA kink-turn motif with pyrrolo cytosine; RNA (5'-R(*GP*GP*CP*GP*A)-D(P*(4PC))-R(P*GP*AP*AP*CP*CP*GP*GP*GP*GP*AP*GP*CP*C)-3') 7eia D 19 3.0 URS00023358B2_32630 32630 ggcgangaaccggggagcc ................... ................... RNA kink-turn motif with pyrrolo cytosine; RNA (5'-R(*GP*GP*CP*GP*A)-D(P*(4PC))-R(P*GP*AP*AP*CP*CP*GP*GP*GP*GP*AP*GP*CP*C)-3') 7eia E 19 3.0 URS00023358B2_32630 32630 ggcgangaaccggggagcc ................... ................... RNA kink-turn motif with pyrrolo cytosine; RNA (5'-R(*GP*GP*CP*GP*A)-D(P*(4PC))-R(P*GP*AP*AP*CP*CP*GP*GP*GP*GP*AP*GP*CP*C)-3') 7eia F 19 3.0 URS00023358B2_32630 32630 ggcgangaaccggggagcc ................... ................... RNA kink-turn motif with pyrrolo cytosine; RNA (5'-R(*GP*GP*CP*GP*A)-D(P*(4PC))-R(P*GP*AP*AP*CP*CP*GP*GP*GP*GP*AP*GP*CP*C)-3') 7eia G 19 3.0 URS00023358B2_32630 32630 ggcgangaaccggggagcc ................... ................... RNA kink-turn motif with pyrrolo cytosine; RNA (5'-R(*GP*GP*CP*GP*A)-D(P*(4PC))-R(P*GP*AP*AP*CP*CP*GP*GP*GP*GP*AP*GP*CP*C)-3') 7eia H 19 3.0 URS00023358B2_32630 32630 ggcgangaaccggggagcc ................... ................... RNA kink-turn motif with pyrrolo cytosine; RNA (5'-R(*GP*GP*CP*GP*A)-D(P*(4PC))-R(P*GP*AP*AP*CP*CP*GP*GP*GP*GP*AP*GP*CP*C)-3') 7eiz I 25 NA URS00021ED98C_2697049 34143953 2697049 gcgguaguagcaugcuagggagcag ......................... ......................... Coupling of N7-methyltransferase and 3'-5' exoribonuclease with SARS-CoV-2 polymerase reveals mechanisms for capping and proofreading; primer 7eiz J 27 NA URS00023119E5_2697049 34143953 2697049 ugacugcucccuagcaugcuacuaccg ........................... ........................... Coupling of N7-methyltransferase and 3'-5' exoribonuclease with SARS-CoV-2 polymerase reveals mechanisms for capping and proofreading; template 7elh N 32 3.3 URS00023119F5_10886 34234134 10886 auauauauauauauauauauauauauauauau ................................ ................................ In situ structure of transcriptional enzyme complex and capsid shell protein of mammalian reovirus at initiation state; RNA (60-MER) 7elh O 32 3.3 URS00023119F5_10886 34234134 10886 auauauauauauauauauauauauauauauau ................................ ................................ In situ structure of transcriptional enzyme complex and capsid shell protein of mammalian reovirus at initiation state; RNA (60-MER) 7elh P 30 3.3 URS00023119F5_10886 34234134 10886 auauauauauauauauauauauauauauau .............................. .............................. In situ structure of transcriptional enzyme complex and capsid shell protein of mammalian reovirus at initiation state; RNA (60-MER) 7elh Q 30 3.3 URS00023119F5_10886 34234134 10886 auauauauauauauauauauauauauauau .............................. .............................. In situ structure of transcriptional enzyme complex and capsid shell protein of mammalian reovirus at initiation state; RNA (60-MER) 7elh R 60 3.3 URS00023119F5_10886 34234134 10886 auauauauauauauauauauauauauauauauauauauauauauauauauauauauauau ............................................................ ............................................................ In situ structure of transcriptional enzyme complex and capsid shell protein of mammalian reovirus at initiation state; RNA (60-MER) 7elh S 60 3.3 URS00023119F5_10886 34234134 10886 auauauauauauauauauauauauauauauauauauauauauauauauauauauauauau ............................................................ ............................................................ In situ structure of transcriptional enzyme complex and capsid shell protein of mammalian reovirus at initiation state; RNA (60-MER) 7elh T 31 3.3 URS00023119F5_10886 34234134 10886 auauauauauauauauauauauauauauaua ............................... ............................... In situ structure of transcriptional enzyme complex and capsid shell protein of mammalian reovirus at initiation state; RNA (60-MER) 7elh U 31 3.3 URS00023119F5_10886 34234134 10886 uauauauauauauauauauauauauauauau ............................... ............................... In situ structure of transcriptional enzyme complex and capsid shell protein of mammalian reovirus at initiation state; RNA (60-MER) 7elq A 45 2.6 RF03054 URS00023119C1_137716 34125892 0002060 137716 gaguagaagcguucagcggccgaaaggccgcccggaaauugcucc <<<<.......<<<.<<<<<<....>>>>>>...>>>...>>>>. (((((....[.(((.((((((....))))))..])))..))))). Crystal structure of xanthine riboswitch with xanthine, manganese saok; NMT1_Mn (46-MER) 7eu0 O 32 3.16 URS0002311A35_32630 34941388 32630 cgagagguacuuuucuuuucuuucuucuucgg ................................ ................................ The cryo-EM structure of A. thaliana Pol IV-RDR2 backtracked complex; RNA (39-MER) 7ez2 N 392 3.05 RF00028 URS00023119AE_5911 34381213 0000372 5911 gguuuggagggaaaaguuaucaggcaugcaccugguagcuagucuuuaaaccaauagauugcaucgguuuaaaaggcaagaccgucaaauugcgggaaaggggucaacagccguucaguaccaagucucaggggaaacuuugagauggccuugcaaaggguaugguaauaagcugacggacaugguccuaaccacgcagccaaguccuaagucaacagaucuucuguugauauggaugcaguucacagacuaaaugucggucggggaagauguauucuucucauaagauauagucggaccucuccuuaaugggagcuagcggaugaagugaugcaacacuggagccgcugggaacuaauuuguaugcgaaaguauauugauuaguuuuggag ..............<<<<<<<<<<..[((.>>>>>>>>>>.<<<<<<<<<<<......<<<<<<.>>>>>.>>>>>>..<<<<<.<....<<<<<<...<<<<<<.....<<<.<<<<.<<...<<<<<<<<<....>>>>>>>>>..<<..)).].>>.....>>......>>>>>>>....>>>>>>..>>.>>>><<...<<<<...<<<<<<<<<...>>>>>>>>>..>>>>...>>.....(((((...>.>>>>>.<<<<<<<.....>>>>>>>........)))))...((.<<<<<....>>>>><<<<<<<....<<<<>>>>>>>>>>....>>>>>>>.<<<<<<<<.<<<<<......>>>>>.>>>>>>>>..)).. ..............((((((((((..{{{.)))))))))).(((((.(((((....(.[[[[[[))))))..)))))..(((((.(....((((((...((((((.....(((.((((.(((..(((((((((....)))))))))..((..}}.}.))....)))......)))))))....))))))..)).))))((...((((...(((((((((...)))))))))..))))...))...[.[[[[[...).))))).(((((((.....)))))))........]]]]]]..((.(((((....)))))(((((((.....(((]]]]]]))).....))))))).((((((((.((((((....)))))).))))))))..)).. Holo L-16 ScaI Tetrahymena ribozyme; Holo L-16 ScaI Tetrahymena ribozyme 7f0d A 3118 3.3 RF02540,RF02541,RF00002 URS00005E0FC6_419947 34935599 0003735 0005840 419947 aagugucuaagggcgcaugguggaugccuuggcaucgagagccgaugaaggacgugggaggcugcgauaugccucggggagcugucaaccgagcguggauccgaggauuuccgaauggggaaacccagcacgagugaugucgugcuacccgcaucugaauauauagggugcgggagggaacgcggggaagugaaacaucucaguacccguaggaggagaaaacaauugugauuccgcaaguaguggcgagcgaacgcggaacaggcuaaaccgcacgcauggguaaccggguagggguugugugugcgggguugugggaggauaugucucagcgcuacccggcugagaggcagucagaaagugucgugguuagcggaaguggccugggauggucugccguagacggugagagcccgguacgcgaaaacccggcaccugccuaguaucaauucccgaguagcagcgggcccguggaauccgcugugaauccgccgggaccacccgguaagccuaaauacuccucgaugaccgauagcggauuaguaccgugagggaauggugaaaaguaccccgggaggggagugaaagaguaccugaaaccgugugccuacaauccgucagagccuccuuuuccucuccggaggaggguggugauggcgugccuuuugaagaaugagccugcgagucagggacaugucgcaagguuaacccgugugggguagccgcagcgaaagcgagucugaauagggcgacccacacgcgcauacgcgcgugugaauaguggcguguucuggacccgaagcggagugaucuacccauggccagggugaagcgcggguaagaccgcguggaggcccgaacccacuuagguugaagacugaggggaugagcuguggguaggggugaaaggccaaucaaacuccgugauagcugguucuccccgaaaugcauuuaggugcagcguugcgugguucaccgcggagguagagcuacuggauggccgauggguuacugacgucagccaaacuccgaaugccgugguguaaagcguggcagugagacggcgggggauaagcuccguacgucgaaagggaaacagcccagaucgccggcuaaggcccccaagcgugugcuaagugggaaaggaugugcagucgcaaagacaaccaggagguuggcuuagaagcagccacccuugaaagagugcguaauagcucacuggucaagugauugugcgccgauaauguagcggggcucaagcacaccgccgaagccgcggcacauccaccuugugguggguguggguaggggagcgucccucauucagcgaagccaccgggugaccggugguggagggugggggagugagaaugcaggcaugaguagcgacaaggcaagugagaaccuugcccgccgaaagaccaaggguuccugggccaggccaguccgcccagggugagucgggaccuaaggcgaggccgacaggcguagucgauggacaacggguugauauucccguacccgugugugggcgcccgugacgaaucagcgguacuaaccacccaaaaccggaucgaucacuccccuucggggguguggaguucuggggcugcgugggaacuucgcugguaguagucaagcgaaggggugacgcaggaagguagccguaccagucagugguaacacuggggcaagccgguagggagagcgauaggcaaauccgucgcucacuaauccugagaggugacgcauagccgguugaggcgaauucggugauccucugcugccaagaaaagccucuagcgagcacacacacggcccguaccccaaaccgacacagguggucagguagagcauaccaaggcguacgagauaacuaugguuaaggaacucggcaaaaugcccccguaacuucgggagaagggggaccggaauaucgugaacacccuugcggugggagcgggauccggucgcagaaaccagugaggagcgacuguuuacuaaaaacacagguccgugcgaagucgcaagacgauguauacggacugacgccugcccggugcuggaagguuaagaggacccguuaacccgcaagggugaagcggagaauuuaagccccaguaaacggcggugguaacuauaaccauccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaacgacuucucaacugucucaaccauagacucggcgaaauugcacuacgaguaaagaugcucguuacgcgcggcaggacgaaaagaccccgggaccuucacuacaacuugguauugauguucgguacgguuuguguaggauaggugggagacugugaaaccucgacgccaguuggggcggagucguuguugaaauaccacucugaucguauugggcaucuaaccucgaacccugaaucggguuuagggacagugccuggcggguaguuuaacuggggcgguugccuccuaaaauguaacggaggcgcccaaagguucccucaaccuggacggcaaucagguggcgaguguaaaugcacaagggagcuugacugcgagacuuacaagucaagcagggacgaaagucgggauuagugauccggcacccccgaguggaaggggugucgcucaacggauaaaagguaccccggggauaacaggcugaucuuccccaagaguccauaucgacgggaugguuuggcaccucgaugucggcucgucgcauccuggggcuggagcaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguuuagaacgucgugagacaguucggucucuauccgccgcgcgcgucagaaacuugaggaaaccugucccuaguacgagaggaccgggacggacgaaccucuggugcaccaguugucccgccaggggcaccgcuggauagccacguucggucaggauaaccgcugaaagcaucuaagcgggaaaccuucuccaagaucagguuucucacccacuuggugggauaaggccccccgcagaacacggguucaauaggucagaccuggaagcucaguaauggguguagggaacuggugcuaaccggccgaaaacuu <<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))...)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>...[.....<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<....<<<<<<<<<<........(((........>>>>>>>>>>......<<<<<<<<<..<<<<<<<....))).>>>>>>><<<<........<<<<<..<<<<.<<<.....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>.>>>>>.>>>>...>>>>..>>>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..>>>....].>>.>>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<..<<<.<<<<<.<.......>..>>>>>.>>>..>>>>...<.<........>.>.<<<<<<....<<<.<<<<<<<<<<..<<<...<<<<..>>>>...>>>...<<....>>..<<<<.....>>>>.....<<<<<<<<....>>>>>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<....<<<<<<<<.....<<<....<<<.<<<<...............>>>>.>>>..>>.>.....>>>>>>>>....>>>>>>>.>>..<<<<<<<<<<......>>>>>>.>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<.........>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>...........)))......>>>>>>.>>>...>>>>>>><<<<<<<<<<....>>>>>>>>>>....>>>>>>..<<<<<<<<<.......<<<<<<<<....>>>>>>>>....>>>>>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<.<<.....<<<<...<<<<<<<.<....<<<<.<<...<<<<<....<<<..<<<<...>>.>>..>>>...>>>>>...>>.>>>>....>>>>>>>>.....>>>>.<<..<<<<<<...<<<<..<<<..<<<<..<<<<<...((((...>>>>>.<<..<<<....<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>....>>>...>>...<<........>>.....>>>>...>>>...>>>>........>>>>>>.>>..>>.>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<....<<......<<<.....>>>.......>.>.>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.<<<....<<<<<.<<<<....>>>>>..>>>>....>>>.>>>>>>>>>..>>>>><<<<<.........>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.((..<<<<<......))>>>>>..<<<<<<<<.<<<.<<......<<<<<<<<<<..<<<<<..<<.<<<<<.<<<<<<<.<<<<<<............................................................................>>>>>>.>>>>>>>...<<<.<<<<<........>>>>>>>>....>>>>>.>>...>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.<<..>>>>..>>>>>>>>>.............>>>>..>>>>>>.......<<<<..<<.<<<<...<<.......>>...>>>>.>>...>>>.>.......<.<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>..>....<<<<<<<....>>>.>>>>....>>..>>>>>>>>>>>....<<<<<<<...<<<...<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))))>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>..>>>.......>>>>>>>..<<<<<...>>>>>....<<<<.<<<<.......>>>>.....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>> .((.......((((((((((.....(((..(((((((((((((......((((((.[[.[[[.))).....((((((...(((]]]..]].)))......))))))...)))....(((....)))(((((((......))))))).(((.((((...........)))).))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...(((....((((((.((........([[[....)....)).))))))....(.((((.(((...(((((((....]]].)))))))((((........(((.((.((((.(((...(.((((......)))))[[(...).(((.....]])))...)))...)))))).))).))))....)))...)))).....(((((((...[.......)))))))....).(.(((].[[[[))).)..)))......)).))))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((..(.(.((((..((.....))...)))).).)..)))).<.(.(........).).((((((....(((.((((((((((...(....(((....)))....).....(....)...((((.....)))).....((((((((....)))))))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......A))))))))..).))))))))).(.(((.....)))...)..))))))......).))..(((((.....(((((....))))).((((((((..(.(.((((((.....(((....(((.((.(....(.....)....).)).)))..)).).....)))))).)...)))))))).)...((((((((((......)))))).))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(...(..(((.....{.(((.....(..(((.........)))...)......(...((......)))....)))...)))..)...).))...........]]].)....))))))))))...)))))))((((.(((((....))))).)))).....)))))(.(((((((.((......((((((((....))))))))...)).)))))))..).....))))))(......((.....((((((.......))))))((((....((((..((...((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(.(((........))).)]]((((((((.(((.....((((....((((((.(....((((.((...((.((.(..((.(.(..(....)..).).).)).)).))...)).))))....)))))))......)))).((...(((((...((((..(((..((((..(((((....{{....))))).((..(((.....((((((((((.((.....))))))))).....)))...[.)))...))...(.(.......)).....))))...)))...))))(..)....)))))..))..)).)))))))))))))..)).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))(((((.....(.....(.((....]))..).....)...)))))(...).......((((((((..].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((....(((...((((....))))....)))....))...))))))))..)))))(.(.(..........)).)........((..........(((((.......)))))..)..)....))))....).))))))).)..))).)))))))).)))))).....))[[..(((((.....>]])))))..((((((((.(((.((......(((((((.((..(((((..((.(((((.((((.((...(((.(...................................(....).................................).)))...)).))))...(((.(((((.(.....)))))))))....))))).))...)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......)).)..))))))......(((((.(.(.((((...((.......))...)))).)...)))).).)......((((.((.(((..((((((((........)))))..))).(((((.....))))).....))).)..)...))).).....(((((((....))).))))..a.))..)))))))))))[...(((((((...(((...(((((((.....(....)....))))))).(((((...((((...((((.((((((.}}.))))))...))))...)))).)))))...(((....((((.....}.......))))....)))..)))..]....)))))))..((((.....))))....((((.((((.......)))).....((((((((.(((....(((((....)))))...)))..))))).)))...)))).....)). Cryo-EM structure of Mycobacterium tuberculosis 50S ribosome subunit bound with clarithromycin; 23S rRNA 7f0d B 115 3.3 RF00001 URS00005330B1_419947 34935599 0003735 0005840 419947 uuacggcggccacagcggcagggaaacgcccggucccauuccgaacccggaagcuaagccugccagcgccgaugauacugccccuccggguggaaaaguaggacaccgccgaaca ...<<<<<<.....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<...<...<<<<<<....>>>>>>.....>.>>...>>>>>>.... .(.((((((.....((((((((.....((((((...(.....)...))))..))....)))))).)).((.......(((((.(...)))))).......))...)))))).).. Cryo-EM structure of Mycobacterium tuberculosis 50S ribosome subunit bound with clarithromycin; 5S ribosomal RNA 7f36 F 76 3.098 RF00005 URS00001ACE3E_562 0030533 0006412 562 gcgggaauagcucaguugguagagcacgaccuugccaaggucggggucgcgaguucgagucucguuucccgcucca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((((.....)))))).....(((((..]....)))))))))))).... TacT complexed with acetyl-glycyl-tRNAGly; RNA (76-MER) 7f36 G 76 3.098 RF00005 URS00001ACE3E_562 0030533 0006412 562 gcgggaauagcucaguugguagagcacgaccuugccaaggucggggucgcgaguucgagucucguuucccgcucca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).(((((.......))))).....(((((..]....)))))))))))).... TacT complexed with acetyl-glycyl-tRNAGly; RNA (76-MER) 7f5s L5 3715 2.72 RF02543,RF02540 URS00023359CB_9606 35674491 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaanggaaaguugaaaagaacuuugaagngngaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcggcccggcggaucuuucccgcgcgggggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcunggaaggcccggcggggaagguggcucgggggcccccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcncucuccccccucccggcggccggggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccgggggaggccacgcgcgcgucccccgaagagggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccnucuugnnacncggaccaaggagunuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgagggngcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuagnacccnanagauggugancuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauagnggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcagacccgacgcccgccacgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuuggnaagcngaacuggcgcuncgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggaugncgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagcggcggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaunuuggugguagunnnaaauauucaaacgagaacuuugaaggccgaaguggngaaggguuccaugngaacagnanuugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcnccgggccguacccnuauccgcagcaggucuncaaggugaacngccucuggnauguuggaacaanguagguaagggaagucggcaagcnggauccguaacuucnggauaaggauuggcucuaagggcugggucggucgggccggcgccuagcagccgacuuagaacuggugcggaccaggngaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugccnagugcucugaaugucanagugnagaaauucaaugaagcgcggnuaaacggcgggaguaacuaugacucucuuaagguagcnaanugccucnucaucuaauuagugangcgcaugaanggaugancgagnuucccacugunccuaccuacuauccagcgaaaccacngncaagggaacgggcuuggnggaaucagcggngaaagaaganccuguugagcuugacncuagucuggcacggugaanagacaugagagguguagaauaagugggaggcccccugcgggccgccggugaaauaccacuacucugaucguuuuuucacugacccggngaggcgggggggcgagccccgaggggcucucgcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccaggugggganuuugacugnggcgguacaccugucaaacgguancgcaggnnuccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucagnacgaauacagaccgugaaagcggggccunacgauccuucugaccuuuuggguuuuaagcaggangugucagaaaaguuaccacagngauaacuggcuuguggcggccangcguucauagcgacgucgcuuuuugauccuungaugucggnucuuccuaucauugugaagcagaauunaccaagcguungaunnuucacccacuaauagggaacgugngcugggnuuagancgucgugagacagguuaguuuuacccuacugaugnuguguuguugccaugguanuccugcncaguacgagaggaaccgcagnuncanacauuugguguaunugcuuggcugaggagccaauggggcgaagcuacnaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccggucccccgccgggguccgguncngagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<<...<<<<<<<<<.......>>>>>.>>>>.....>>>>>..<<<<<<<<<<...<<<..<<<........<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>...>>>..>>>..>>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<<<..<<<<<<<.......<.....<<<<.<<<..<<<....>>>>>>>>>>.>......>>>>...>>>>>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<.<<<<<<<<<<<<<<<...<<..<<<....<<<<......<<<<<<<....>>>>>>>.......>>>>...>>>........>>>>>>..>>>>>>>>>>>....................<<<<<<.<<<<<<<...........>>>>>>>.<<<<<<.<<<<.<<<<<<<<<<<.<<<<<.<<<<..<...........>...>>>>.>>>>>.>.>>>>>>>.>>>...>>>>..>>>>.>>..<<<<<<<<<<.....>>>>>>>>.>>....>>>>>>......>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<..........>>>>>..<<<<<...<<<..<<<..[[[..((((>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<......................<<<.<<<<<<<<<...<<<....<<...<.<<<<....<.............>..>>>>.>...>>..>.>>...>>>>>>>...<<<<<<<<<.........>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<..........<<.<<.....................>>......................>>......>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<..........))))..]]].......................>>>>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<...<...>...>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<..<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<...............>>>>><<.<<<<<<<<<<<..<<.........>>.......>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<<..<<............................................................>>...>>>>>>>>...<<<<<.....<<<<........<<......>>...................<<<<<<<<<<.......>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>><<<<....>>>>>>)))].....<<<<<<<..<<<..)))))).>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<..<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<....<<<<<.................>>>>>..<<<<....<<<<....<<.<<<<<<<]]].>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.....<<<<<<<.<<..<<<<....<<<........<<<<<.<<<<....>>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>..............>>>>..>>>>>>>>><<<<<....................<<.<<<<<<<.<<.....<<<<....<<<<<......>>>>>...>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((...((((((((.(......))))).)))).....)))....((((((((((...(((.((((...(....((((((((..({((((......)))))....[[(...).(((....}]])))...).))))))))..))).))))..))))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....(((((((((((..(((((((..(.(..(.....((((.(((...(......).))))))).)..))..))))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((..(.((((......(((((((....))))))).......))))..))))........))))))..)))))))))))....................((((((.(((((((....(...)..))))))).((((((.((((.(((((((((((.(((((.((((..................)))).))))).).))))))).)))...))))..)))).))..(..((((((.......))))))...)..[.)))))).....))).)))))...)))))...)))))))).<((((........))))((((((....(((((((((((((..(((..(((((........))))..)..)))...((....))...(((((..........)))))..(((((...(((..(((..[[....[.[)))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((......................(((.((((((((.....((.....((.....((.......................)).....))...))......))))))...(((((((((.(......))))))))))....))))))))))))..))..((((..(.((.....)).)..))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.....{.(........................................................)...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((...........]]....]]].........(...)........)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((..(((((((...((.....)).))))))....[[(((.((...(.....(((....)))..........((.((((....(...)....)))))).......)....))...(((((........)))))]]((((....(((((...((.((((....)))).))..((((....)))...(...((((((...((((((((((((((((((((((...{{{...)))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....(((((((.......))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).))).))).....((......)).)))).((((.....))))..)))....((((.....(.(((.(.((..(....(.......(((((....(.[..).....)))))((.(((((((((((...(.(......))........)))))..)))))).))(...).......(((((((((.>.(...........)...(((((((....((((.....))))......))))))).].(.(.(((..((((((.(...(......((.(....).))......).)))))..)))))(.(.(.........).).)........((..........(((((.......)))))..)..)....).)....)).))))))).)..))).).))).)..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.(((((...(((((.(((((((((.((((((((........(..................................................).........))))))))...(((((.....((((.....(..............)................((((((((((.......))))))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(..((....((....{..))....)).)(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}.....)))..)))))).......(....(.((((.(...((.......))...).))))...)....)........((((.((((((..(.(.(.(((......))).)...).)..((.(.....).))......)))))..)...))).)......((((((....))).)))...a.))..))).))))).....(.((.(.(..(((....(((((......(....).....)))))..(((.....((((....((.(((((((}}}.)))))..)).))...))))....))).((((...((((.....}.......))))...))))..)))...).).)).).....((((((..((..((((.(..(((........(((((.((((....)))).))))).......)))...(((..((((....((((.(((((((......)))))))))))...))))..)))...........)..))))..)).))))))(((((.(..(.......)..)....((.(((((((.((.....((((.(..(((((......)))))..)))))....))....)))).))).))..))))).. human delta-METTL18 60S ribosome; 28S rRNA 7f5s L7 120 2.72 RF00001 URS000002B0D5_9606 35674491 0003735 0005840 9606 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. human delta-METTL18 60S ribosome; 5S rRNA 7f5s L8 156 2.72 RF00002 URS00004B2C76_9606 35674491 0003735 0005840 9606 cgacucuuagcggnggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<<<<....>>>>.....<.<<<......>>.............>>>..>...>>>....<<....>><<<<<<<<<.....>>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))(((((((((.....))))))))).................... human delta-METTL18 60S ribosome; 5.8S rRNA 7f8z A 19 3.0 URS00023358D6_32630 32630 ggcgangaaccggggagcc ................... ................... RNA kink-turn motif with 2-aminopurine; RNA (5'-R(*GP*GP*CP*GP*A)-D(P*(2PR))-R(P*GP*AP*AP*CP*CP*GP*GP*GP*GP*AP*GP*CP*C)-3') 7f8z B 19 3.0 URS00023358D6_32630 32630 ggcgangaaccggggagcc ................... ................... RNA kink-turn motif with 2-aminopurine; RNA (5'-R(*GP*GP*CP*GP*A)-D(P*(2PR))-R(P*GP*AP*AP*CP*CP*GP*GP*GP*GP*AP*GP*CP*C)-3') 7f8z C 19 3.0 URS00023358D6_32630 32630 ggcgangaaccggggagcc ................... ................... RNA kink-turn motif with 2-aminopurine; RNA (5'-R(*GP*GP*CP*GP*A)-D(P*(2PR))-R(P*GP*AP*AP*CP*CP*GP*GP*GP*GP*AP*GP*CP*C)-3') 7f8z D 19 3.0 URS00023358D6_32630 32630 ggcgangaaccggggagcc ................... ................... RNA kink-turn motif with 2-aminopurine; RNA (5'-R(*GP*GP*CP*GP*A)-D(P*(2PR))-R(P*GP*AP*AP*CP*CP*GP*GP*GP*GP*AP*GP*CP*C)-3') 7f8z E 19 3.0 URS00023358D6_32630 32630 ggcgangaaccggggagcc ................... ................... RNA kink-turn motif with 2-aminopurine; RNA (5'-R(*GP*GP*CP*GP*A)-D(P*(2PR))-R(P*GP*AP*AP*CP*CP*GP*GP*GP*GP*AP*GP*CP*C)-3') 7f8z F 19 3.0 URS00023358D6_32630 32630 ggcgangaaccggggagcc ................... ................... RNA kink-turn motif with 2-aminopurine; RNA (5'-R(*GP*GP*CP*GP*A)-D(P*(2PR))-R(P*GP*AP*AP*CP*CP*GP*GP*GP*GP*AP*GP*CP*C)-3') 7f8z G 19 3.0 URS00023358D6_32630 32630 ggcgangaaccggggagcc ................... ................... RNA kink-turn motif with 2-aminopurine; RNA (5'-R(*GP*GP*CP*GP*A)-D(P*(2PR))-R(P*GP*AP*AP*CP*CP*GP*GP*GP*GP*AP*GP*CP*C)-3') 7f8z H 19 3.0 URS00023358D6_32630 32630 ggcgangaaccggggagcc ................... ................... RNA kink-turn motif with 2-aminopurine; RNA (5'-R(*GP*GP*CP*GP*A)-D(P*(2PR))-R(P*GP*AP*AP*CP*CP*GP*GP*GP*GP*AP*GP*CP*C)-3') 7f8z I 19 3.0 URS00023358D6_32630 32630 ggcgangaaccggggagcc ................... ................... RNA kink-turn motif with 2-aminopurine; RNA (5'-R(*GP*GP*CP*GP*A)-D(P*(2PR))-R(P*GP*AP*AP*CP*CP*GP*GP*GP*GP*AP*GP*CP*C)-3') 7f8z J 19 3.0 URS00023358D6_32630 32630 ggcgangaaccggggagcc ................... ................... RNA kink-turn motif with 2-aminopurine; RNA (5'-R(*GP*GP*CP*GP*A)-D(P*(2PR))-R(P*GP*AP*AP*CP*CP*GP*GP*GP*GP*AP*GP*CP*C)-3') 7jil 1 2742 2.8 RF02540,RF02541 URS00023119D4_986 33330920 0003735 0005840 986 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......<<<<<<<<<<.....<<<..<<<<<<<<<<<<<......<<<<<<.....((.>>>.....<<<<<<<..<<<)).....>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<.....>>>>>>>.<<<<....>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>.......<.<<......<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>.......>>......>........<<<<<<<...........>>>>>>>......<<<<<..<<<<>>>>>..>>>......>>.>>>>>>>.>>...............<<....>>....>>.........<<<<.....>>>>.............>.....>>>>>>>>>>.......<<<<..<<<<<.....>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.<...>>>>...>>>...<<....>>..<<<<.....>>>>......>>>>>>>>>>>>>..<<.<...<<<.<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<...<<<........>>>..>>>....>>>>>>>>>...<<<.....>>>......>>.>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<......<<<<<<<<<.....<<<....<<.<.<<<....<<<<.........>>.>>...>>>.>.>>..>>.>.....>>>>>>>>>....>>>>>>.>>..<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<.....<<......<<..<<<<<<<<<<.......<<<<<.<<<..<<<<.......>>>>>>>.......<<......>>...>>>>>...>>>>>>>>>>.>>..........)))>>...>>>>>>.>>>...>>>>>>><<<<<<<<..>>>>>>>>....>>>>>>..<<<<<<<.<.......<<<<<<<<....>>>>>>>>....>.>>>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<<...<<<<<.......<<<<.<<<<<<....[[....>>>>>>....<<<....<<<..<<.<<<<<<.<<.....>>>>>>>>.>>>>>....>>>.......<<<...<<..>>...>>>.....>>>>......>>>>>........>>>>>...>>....>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<<....>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<..<<...<<<<<<.<<....>>..>>>>>>...>>..>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.<<......<<<<.<<<<<<..<<<<<.<<<.<<<<<.<.<<<<<<<<<<<..>>>>>>>>>>>.>...<<<<<<.>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<.........>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..>>>>..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<.<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>...>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.]].>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<.....<<<<....>>>>...>>>..>>>>>.>>>...>>>>. ......((((((((((.....(((..(((((((((((((......((((((.....[[.))).....((((((...(((]].....)))......))))))...)))....(((....)))(((((((.....))))))).((((....)))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...((((..((.....))..))))....{.(((((..(...((....(((((......)))))[[(...).(((.....]])))....))....)..))...)..)..))....(((((((...[.......)))))))....}.(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((.....)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...(((.(...))))...)))...((....))..((((.....))))......)))))))))))))..((.(...(((.((.....((((((((((.((((...((((((......))))))...)[)))...(((...(((.......<)))..)))..).))))))))).(.(((.....)))...)..)).)))......).))..((((((....(((((....)))))((((((((....(.(((((((((.....(((....((...(((...((.((.........)).))...)))...))..)).).....))))))))).)..)))))).))..((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....((......((..(((((((.((.....{.(((((.(((..(((.........)))))).....(.((......)).).)))))...)).))))))).))..........]]]))...))))))))))...)))))))((((((((..))))))))....))))))(.(((((((.((......((((((((....))))))))...)).)))))))..).....))))))(......((.....((((((.......))))))((((....(((...((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((((((((((...((((....(((((.......((((((((((((...{{...)))))))....(((....(((..((.((((((.((.....)))))))).)))))....))).......(((...((()))...)))...).))))......)))))(..).....))))...))....))))))))))))))).))).....((......))..))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((....)))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((..((....))...)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(.(((((((((((..))))))))))).)...((((((.))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...(((...(((...{..)))...))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.(.((((..(((((((((......))))))..))).(((((.....))))).....))))...)...))).).....(((((((....))).))))..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....))))))).....(((.(((((.......)))))....((((((((.(((.....((((....))))...)))..))))).)))....))). 70S ribosome Flavobacterium johnsoniae; RNA (2862-MER) 7jil 2 1475 2.8 RF00177,RF01959,RF01960 URS00021ED92B_986 33330920 0003735 0005840 986 uacgaugaagaguuugauccuggcucaggaugaacgcuagcggcaggcuuaacacaugcaagucgagggguagagaccggcgcacgggugcguaacgcguaugcaaucugccuuucacagagggauagcccagagaaauuuggauuaauaccucauaguauuauagagcggcaucacuuuauaauuaaagucacaacggugaaagaugagcaugcgucccauuagcuaguugguaagguaacggcuuaccaaggccacgauggguagggguccugagagggagaucccccacacugguacugagacacggaccagacuccuacgggaggcagcagugaggaauauuggucaauggacgcaagucugaaccagccaugccgcgugcaggaugacgguccggauuguaaacugcuuuuguacgagaagaaacacuccuauauauaggagcuugacgguaucguaagaauaaggaucggcuaacuccgugccagcagccgcgguaauacggaggauccaagcguuauccggaaucacuggguuuaaaggguccguaggcgguuuaguaagucaguggugaaagcccaucgcucaacgguggaacggccauugauacugcugaacuugaauuacugggaaguaacuagaauauguaguguagcggugaaaugcuuagauauuacauggaauaccaauugcgaaggcagguuacuaccaguuuauugacgcugauggacgaaagcguggggagcgaacaggauuagauacccugguaguccacgccguaaacgauggauacuagcuguugggcgcaaguucaguggcuaagcgaaagugauaaguaucccaccuggggaguacgaacgcaaguuugaaacucaaaggaauugacgggggcccgcacaagcgguggaacaugugguuuaauucgaugauacgcgaggaaccuuaccaaggcuuaaaugcagacugcgauuuggaaacagaucucaguuuacaaggugcugcaugguugucgucagcucgugccgugaggugucagguuaaguccuauaacgagcgcaaccccuguuguuaguugccagcgaggaacucuaacaagacugccagugcaaacugugaggaagguggggaugucaaaucaucacggcccuuacgccuugggcuacacacgugcuacaauggccgguacagagagcagccacugggugaccaggagcgaaucuauaaagccggucacaguucggaucggagucugcaacucgacuccgugaagcuggaaucgcuaguaaucggauaucagccaugauccggugaauacguucccgggccuuguacacaccgcccgucaagccauggaagcugggggugccugaagucggugaccgcaaggagcugccuaggguaaaacugguaacuagggcuaagucguaacaagguagccguaccggaaggugcggcuggaacaccuccuuucu .........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<........>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<....<.<<<<......>>>>.>.....>>>>.....<<<<<<<<<........>>>>>>>>>....<<....>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<.<<.>>.>......>>>>.....<<<<<..........<<<<<....>>>>>...........>>>>>.......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<<..<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<.<<<<<..<<<<<<<....<<<<<<<<<..<<<......>>>.....>>>>>>>>>..........<<<....>>>>>>>>>>.>>>>>..>>>...>>>..>>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<<<<<<<<<<<<<....>>>>>>>>>>>>.<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<.<<<<<<<<......<<........>>..........<<<<<<<.....<<.<<<<<<.<<<<<<....>>>>>>.>>>>>>.>><<<.<<<...<<<<<.......<<<<<<<<<....>>>...<<<......>>>...>>>>>>.....<<<..<<<<<<<...<<.....>>....>>>>>>>......<<<......>>>..........>>>.......>>>...>>.>>>>>>...>>>>>>>...>>.>>>>>>.>.....<<<<<<<......<<..<<..<<<<....>>>>..>>....>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<...<<<<<..<<.<<<<..<<....>>.>>>>.>>.>>>>>...>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>................ .........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((........)))))......(((......((((((((..((...(((((((...((......(((((....))))).......)).......((((.(.((.(....).)).).))))....((....)).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......(.((.)).)......)))).....(((((...(......(((........)))......)....))))).......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..((((.(((((..((((((((....(((((((...((........))......)))))))....).......((....)).))))))).)))))..)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((....))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..(.((.(((((......((........))..........(((((((.....((.(.((((..(((((....)))))..)))).).)).((.(((...(((.((......(((((((((....)))...(((......)))...)))))).....(((..(((((((...((.....))....)))))))......((((....))))..........))).....).).)...)).)))))....)))))))...)).))).)).).(...(((.(((......((..(((.((((....))))).))....)).....))).)))......(....(((((((........)))))))....)..)..))))).....(((((((..........)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((...(((((...(.((((..((....)).)))).)..)))))...)))))..))..))))..).))...)..)..(((((((((....)))))))))}............... 70S ribosome Flavobacterium johnsoniae; RNA (1519-MER) 7jil 3 110 2.8 RF00001 URS00021ED950_986 33330920 0003735 0005840 986 uaaggugguuauugcggcggggcucaccucuucccaucccgaacagagaaguuaagcccgcuugcgcagaugguacugcaguuuugugggagaguaugucgucgccuuuc .<<<<<<<.....<<<<<<<<....<<<<<<.............>>>>..>>....>>>>>>.>><<<.......<<<<<....>>>>>.......>>>..>>>>>>>.. .((((((((....((((((((....((((((...(.....)...))))..))....)))))).))(((.......(((((....))))).......))).)))))))).. 70S ribosome Flavobacterium johnsoniae; RNA (111-MER) 7jju A 51 2.604 RF04222 URS00021ED9C7_12045 32848042 0039694 12045 ngaacuagcucagcauacacgaguugcaagcaugggaaguucaagccucgn .<<<<<..<<<<<<...............>>.>>>>.>>>>>......... .(((((.[((((((............]..)).)))).)))))......... Crystal structure of en exoribonuclease-resistant RNA (xrRNA) from Potato leafroll virus (PLRV); Potato leafroll virus xrRNA 7jju B 51 2.604 RF04222 URS00021ED9C7_12045 32848042 0039694 12045 ngaacuagcucagcauacacgaguugcaagcaugggaaguucaagccucgn .<<<<<..<<<<<<...............>>.>>>>.>>>>>......... .(((((.[((((((............]..)).)))).)))))......... Crystal structure of en exoribonuclease-resistant RNA (xrRNA) from Potato leafroll virus (PLRV); Potato leafroll virus xrRNA 7jl0 X 14 4.3 URS00021ED96A_9606 33373584 9606 gacugacugacuga .............. .............. Cryo-EM structure of MDA5-dsRNA in complex with TRIM65 PSpry domain (Monomer); RNA (5'-R(P*GP*AP*CP*UP*GP*AP*CP*UP*GP*AP*CP*UP*GP*A)-3') 7jl0 Y 14 4.3 URS00021ED967_9606 33373584 9606 ucagucagucaguc .............. .............. Cryo-EM structure of MDA5-dsRNA in complex with TRIM65 PSpry domain (Monomer); RNA (5'-R(P*UP*CP*AP*GP*UP*CP*AP*GP*UP*CP*AP*GP*UP*C)-3') 7jl1 X 14 3.9 URS00021ED96A_9606 33373584 9606 gacugacugacuga .............. .............. Cryo-EM structure of RIG-I:dsRNA in complex with RIPLET PrySpry domain (monomer); dsRNA strand 1 7jl1 Y 14 3.9 URS00021ED967_9606 33373584 9606 ucagucagucaguc .............. .............. Cryo-EM structure of RIG-I:dsRNA in complex with RIPLET PrySpry domain (monomer); dsRNA strand 2 7jl2 X 44 4.3 URS00021ED97D_9606 33373584 9606 gacugacugacugaagacugacugacugaagacugacugacuga ............................................ ............................................ Cryo-EM structure of MDA5-dsRNA filament in complex with TRIM65 PSpry domain (Trimer); RNA (44-MER) 7jl2 Y 44 4.3 URS00021ED940_9606 33373584 9606 ucagucagucagucuucagucagucagucuucagucagucaguc ............................................ ............................................ Cryo-EM structure of MDA5-dsRNA filament in complex with TRIM65 PSpry domain (Trimer); RNA (44-MER) 7jl3 X 42 4.2 URS00021ED9CE_9606 33373584 9606 gacugacugacugagacugacugacugagacugacugacuga .......................................... .......................................... Cryo-EM structure of RIG-I:dsRNA filament in complex with RIPLET PrySpry domain (trimer); dsRNA strand1 7jl3 Y 42 4.2 URS00021ED973_9606 33373584 9606 ucagucagucagucucagucagucagucucagucagucaguc .......................................... .......................................... Cryo-EM structure of RIG-I:dsRNA filament in complex with RIPLET PrySpry domain (trimer); dsRNA strand 2 7jnh A 25 2.89 URS00021ED909_32630 33414189 32630 aaaaaaaaaaaaaaaaaaaaaaaaa ......................... ......................... Crystal structure of a double-ENE RNA stability element in complex with a 28-mer poly(A) RNA; 28-mer poly(A) RNA 7jnh B 86 2.89 URS00021ED9A5_4530 33414189 4530 gggcugaguuuuuacaugacaaaguuuuuaacgaggcagcggcgaaagucgcuguacucuuuucuuugucaugguuuucucagccn <<<<<<<<.....<<<<<<<<<<<.....<..<<<<<<<<<<......>>>>>>>.>>>.>..>>>>>>>>>>.>...>>>>>>>> ((((((((......((((((((((........(((((((((((....)))))))).)))....)))))))))).....)))))))) Crystal structure of a double-ENE RNA stability element in complex with a 28-mer poly(A) RNA; Core double ENE RNA (Xtal construct) from Oryza sativa transposon,Core double ENE RNA (Xtal construct) from Oryza sativa transposon 7jql 1A 2871 3.0 RF02540,RF02541,RF00002 URS00001698E8_300852 32787108 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<..<<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<....<<<<........>>>.>....>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..<<<.....(.>>>...>>>.........<<......>>.).>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>>....<<<..>>>......>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)..)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((....(((.(......).)..))...)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((..((.........))...))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((..))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.(((((.....))))).))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((..((((((((.(......[..(((((..(((......((((((((....))))))))...)))..........].)))))).))))))))..))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..(((...)))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with Bac7-001, mRNA, and deacylated P-site tRNA at 3.00A resolution; 23S Ribosomal RNA 7jql 1B 120 3.0 RF00001 URS000080DEE8_300852 32787108 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>>> (((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).))))))))))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with Bac7-001, mRNA, and deacylated P-site tRNA at 3.00A resolution; 5S Ribosomal RNA 7jql 1a 1500 3.0 RF00177,RF01959,RF01960 URS000080DFED_300852 32787108 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<......>>....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((((((....))))))).)))))......(((......((((((((..((...(((((((.(((((....(((((......))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((.(((((((...))))))).))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((...(((((((....)))))))....(((....)))....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the Thermus thermophilus 70S ribosome in complex with Bac7-001, mRNA, and deacylated P-site tRNA at 3.00A resolution; 16S Ribosomal RNA 7jql 1v 13 3.0 32787108 10665 aaaaauguucuaa ............. ............. Crystal structure of the Thermus thermophilus 70S ribosome in complex with Bac7-001, mRNA, and deacylated P-site tRNA at 3.00A resolution; mRNA 7jql 1x 76 3.0 RF00005 URS000041AF00_562 32787108 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with Bac7-001, mRNA, and deacylated P-site tRNA at 3.00A resolution; P-site tRNA 7jql 2A 2800 3.0 RF02540,RF02541,RF00002 URS00001698E8_300852 32787108 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<........>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<..>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<..>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<...<<......<<<<<<<<....>>>>>>>>...>>.............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>......>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....(())....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...((..((((....(((..........)).)....))))..))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((.().)))))))).))..........]]].)....))))))))))...)))))))(((((((..)))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(.(((.........))).)........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((.(((((((((.(.........(((((...((.......((((.((....)).))))....)).............)))))).))))))))).))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(............(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))...)))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with Bac7-001, mRNA, and deacylated P-site tRNA at 3.00A resolution; 23S Ribosomal RNA 7jql 2B 120 3.0 RF00001 URS000080DEE8_300852 32787108 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>>. ...((((((((....((((((.(....(.(((((...(.....)...))))..).)...).)))).))(((.......((((((((....)))))))).......))).))))))))... Crystal structure of the Thermus thermophilus 70S ribosome in complex with Bac7-001, mRNA, and deacylated P-site tRNA at 3.00A resolution; 5S Ribosomal RNA 7jql 2a 1503 3.0 RF00177,RF01959,RF01960 URS000080DFED_300852 32787108 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggau .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<....<<<......>>>.......>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<......>>....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>.... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......(((......))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((.((((((.......((((((.....)))))).....))))))...)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((((((....)))))))....(((....)))....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..(.((....)).)..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}... Crystal structure of the Thermus thermophilus 70S ribosome in complex with Bac7-001, mRNA, and deacylated P-site tRNA at 3.00A resolution; 16S Ribosomal RNA 7jql 2v 13 3.0 32787108 10665 aaaaauguucuaa ............. ............. Crystal structure of the Thermus thermophilus 70S ribosome in complex with Bac7-001, mRNA, and deacylated P-site tRNA at 3.00A resolution; mRNA 7jql 2x 76 3.0 RF00005 URS000041AF00_562 32787108 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with Bac7-001, mRNA, and deacylated P-site tRNA at 3.00A resolution; P-site tRNA 7jqm 1A 2871 3.05 RF02540,RF02541,RF00002 URS00001698E8_300852 32787108 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<....<<<<........>>>.>....>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..........(.......>>>.........<<......>>.).>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>>....<<<..>>>......>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<<..>>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((.(((((...((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))..)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((.(....(.(......).)....)..)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((..((.........))...))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((.((((((((((((.(......[..(((((..(((.......(((((((....)))))))....)))..........].)))))).)))))))))))).)))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..(((...)))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with Bac7-002, mRNA, and deacylated P-site tRNA at 3.05A resolution; 23S Ribosomal RNA 7jqm 1B 120 3.05 RF00001 URS000080DEE8_300852 32787108 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> (((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).))))))))))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with Bac7-002, mRNA, and deacylated P-site tRNA at 3.05A resolution; 5S Ribosomal RNA 7jqm 1a 1500 3.05 RF00177,RF01959,RF01960 URS000080DFED_300852 32787108 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<.<<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<<....>>>....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((((((....))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((((((....)))))))....(((....)))....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the Thermus thermophilus 70S ribosome in complex with Bac7-002, mRNA, and deacylated P-site tRNA at 3.05A resolution; 16S Ribosomal RNA 7jqm 1v 13 3.05 32787108 10665 aaaaauguucuaa ............. ............. Crystal structure of the Thermus thermophilus 70S ribosome in complex with Bac7-002, mRNA, and deacylated P-site tRNA at 3.05A resolution; mRNA 7jqm 1x 76 3.05 RF00005 URS000041AF00_562 32787108 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with Bac7-002, mRNA, and deacylated P-site tRNA at 3.05A resolution; P-site tRNA 7jqm 2A 2800 3.05 RF02540,RF02541,RF00002 URS00001698E8_300852 32787108 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<.....<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>.>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>..<....<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<..........>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<..>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>>.<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<....<......<<<<<<<<....>>>>>>>>...>..............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....((((((((..[......))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((()))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..((.((((((...(((...(((.((((.....((..........))......)))).)))..)).)...)))))).))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((.().)))))))).))..........]]].)....))))))))))...)))))))(((((((())))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.(((((.....))))).))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((.(((((((((........[..(((((...((......(((((.((....)).)))))...))...........].)))))..))))))))).))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((.(.........).)))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((...............))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(((...)).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with Bac7-002, mRNA, and deacylated P-site tRNA at 3.05A resolution; 23S Ribosomal RNA 7jqm 2B 120 3.05 RF00001 URS000080DEE8_300852 32787108 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<........<<<<<<<....>>>>>>>........>>>.>>>>>>>>>>. .(((((((((.....((((((.(....(((((((...(.....)...))))..)))...).)))).))(((.......((((((((....)))))))).......)))..))))))))). Crystal structure of the Thermus thermophilus 70S ribosome in complex with Bac7-002, mRNA, and deacylated P-site tRNA at 3.05A resolution; 5S Ribosomal RNA 7jqm 2a 1503 3.05 RF00177,RF01959,RF01960 URS000080DFED_300852 32787108 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggau .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<....<<<......>>>.......>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<......>>....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(.(((....)))..))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...((((((......)))))).(..(((....)))..).)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}... Crystal structure of the Thermus thermophilus 70S ribosome in complex with Bac7-002, mRNA, and deacylated P-site tRNA at 3.05A resolution; 16S Ribosomal RNA 7jqm 2v 13 3.05 32787108 10665 aaaaauguucuaa ............. ............. Crystal structure of the Thermus thermophilus 70S ribosome in complex with Bac7-002, mRNA, and deacylated P-site tRNA at 3.05A resolution; mRNA 7jqm 2x 76 3.05 RF00005 URS000041AF00_562 32787108 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(.(((..]....))).)))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with Bac7-002, mRNA, and deacylated P-site tRNA at 3.05A resolution; P-site tRNA 7jqq K 117 4.1 RF00044 URS00023119C3_10756 33962953 10756 ggaaugguacgguacuuccauugucauguguauguuggggauuaaacccugauugaguucagcccacauacuuuguugauugguugucaaucauggcaaaagugcacgcuacuuucc .<<..<.<<<<.<<<<<....<<<<<<<..<<<<..<<<.........<<<<......>>>>>>>.>>>>.......<<<.....>>>...>>>>>>>.>>>>>..>>.>>.>.>>. ((((..((((((.((((...((((((((...(((..(((.........((.(......).))))).)))........(.(.....).)...)))))))))))).).)).))).)))) The bacteriophage Phi-29 viral genome packaging motor assembly; pRNA (117-MER) 7jqq L 117 4.1 RF00044 URS00023119C3_10756 33962953 10756 ggaaugguacgguacuuccauugucauguguauguuggggauuaaacccugauugaguucagcccacauacuuuguugauugguugucaaucauggcaaaagugcacgcuacuuucc ......<.<<<.<<<<....<<<.<<....<<<<.<<<<.........<<<<......>>>>>>>>>>>>......<<<<.....>>>>....>>.>>>.>>>>..>>.>.>..... (.....((.(((.((.(...(((.((.(...(((.((((.........((((......))))))))))).......(((.......)))..).)).))).))).).))..))....) The bacteriophage Phi-29 viral genome packaging motor assembly; pRNA (117-MER) 7jqq M 117 4.1 RF00044 URS00023119C3_10756 33962953 10756 ggaaugguacgguacuuccauugucauguguauguuggggauuaaacccugauugaguucagcccacauacuuuguugauugguugucaaucauggcaaaagugcacgcuacuuucc <<<..<<<<<<.<<<<......<<<<<<....<<.<<<<.........<<<<......>>>>>>>>>>........<<<<.....>>>>..>>>>>>...>>>>..>>.>>>>.>>> ((((..(((((((((((....((.(.((....((.((((.........((((......))))))))))........(((.......)))..)).).)).)))))).)).))).)))) The bacteriophage Phi-29 viral genome packaging motor assembly; pRNA (117-MER) 7jqq N 117 4.1 RF00044 URS00023119C3_10756 33962953 10756 ggaaugguacgguacuuccauugucauguguauguuggggauuaaacccugauugaguucagcccacauacuuuguugauugguugucaaucauggcaaaagugcacgcuacuuucc <<<<.<<<<<<<<<<<<...<<<<<<<<....<<.<<<<.........<<<<......>>>>>>>>>>.......<<<<<.....>>>>>.>>>>>>>>>>>>>>.>>.>>>>>>>> ((((..((((((.((((...(((.((((...(((.((((.........((((......))))))))))).......((.........))..)))).))))))).).)).))).)))) The bacteriophage Phi-29 viral genome packaging motor assembly; pRNA (117-MER) 7jqq O 117 4.1 RF00044 URS00023119C3_10756 33962953 10756 ggaaugguacgguacuuccauugucauguguauguuggggauuaaacccugauugaguucagcccacauacuuuguugauugguugucaaucauggcaaaagugcacgcuacuuucc <.<...<<.<<<<<<<<....<<<<<<<.<.....<<<<.........<<<<......>>>>>>>>..>.....<.<<<<.....>>>>.>>>>>>>>.>>>>>>.>>..>>..>.> ((((...(((((.((((....((.((((.....(.((((.........((((......))))))))).........(.((.....)).)..)))).)).)))).).)).))..)))) The bacteriophage Phi-29 viral genome packaging motor assembly; pRNA (117-MER) 7jrr A 51 2.16 URS000231196B_32630 34550747 32630 ngacgggagcugaaccauccagcgaagaacgucccgacggaugguucgucg <<<<<...<<<<.......>>>>......>>>>><<<<<.......>>>>> (((((...((((.......))))......)))))(((((.......))))) Crystal structures of artificially designed homomeric RNA nanoarchitectures; RNA (50-MER) 7jrs A 129 3.21 URS00023119EB_32630 34550747 32630 ggacgcgguagcgaagaaccaucgacugcgacuuagcgagccugcccuggcagugggagccugaagcaggcacgggcgaagaacacugucaggucgcugagucggcgucccaguugauggggagcuacc .......<<<<<......<<<<<<<<<<<<<<<<<<<<<......<<<<<<<<<<...<<<<...........>>>>......>>>>>>>>>>>>>>>>>>>>>......>>>>>>>>>>...>>>>>. .......(((((......(((((.(((((((((.(((((......((((((((((...(((.............)))......))))))))))))))).)))))......)))).)))))...))))). Crystal structures of artificially designed homomeric RNA nanoarchitectures; RNA 3D nanocage 7jrs B 129 3.21 URS00023119EB_32630 34550747 32630 ggacgcgguagcgaagaaccaucgacugcgacuuagcgagccugcccuggcagugggagccugaagcaggcacgggcgaagaacacugucaggucgcugagucggcgucccaguugauggggagcuacc .......<<<<<......<<<<<<<<<<<<<<<<<<<<<......<<<<<<<<<<...<<<<...........>>>>......>>>>>>>>>>>>>>>>>>>>>......>>>>>>>>>>...>>>>>. .......(((((......(((((((((((((((.(((((......((((.(((((...(((.(.........).)))......))))).))))))))).)))))......))))))))))...))))). Crystal structures of artificially designed homomeric RNA nanoarchitectures; RNA 3D nanocage 7jrt A 134 3.07 URS00023119B2_32630 34550747 32630 ggauauucgacggaggcacccaggaacuaccguugaagcucgcacgacggccuggggucgaguaucccgguauuugucgcgagcacugaggaacuacugcugaagccuccacggcagccucaggacaaguaccg <<<<<<<<<<<.......<<<<<<.....<<<<<<..((((((.>>>>>>>>>>>>>>>>>>>>>>><<<<<<<<<<.)))))).<<<<<<.....<<<<<<.........>>>>>>>>>>>>.>>>>>>>>>> (((((((((((.......((((((.....((((((..[[[[[[.)))))))))))))))))))))))((((((((((.]]]]]].((((((.....((((((.........)))))))))))).)))))))))) Crystal structures of artificially designed homomeric RNA nanoarchitectures; RNA nano bracelet 7jrt B 134 3.07 URS00023119B2_32630 34550747 32630 ggauauucgacggaggcacccaggaacuaccguugaagcucgcacgacggccuggggucgaguaucccgguauuugucgcgagcacugaggaacuacugcugaagccuccacggcagccucaggacaaguaccg <<<<<<<<<<<.......<<<<<<.....<<<<<<..((((((.>>>>>>>>>>>>>>>>>>>>>>><<<<<<<<<<.)))))).<<<<<<.....<<<<<...........>>>>>>>>>>>.>>>>>>>>>> (((((((((((.......((((((.....((((((..[[[.[[.)))))))))))))))))))))))((((((((((.]].]]].((((((.....((((((.........)))))))))))).)))))))))) Crystal structures of artificially designed homomeric RNA nanoarchitectures; RNA nano bracelet 7jss 3 1539 3.7 RF00177,RF01959,RF01960 URS00021ED9C1_83333 33144582 0003735 0005840 83333 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggcgaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<..<<<<........>>>>...>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<..<<...<<<<<<......>>>>>.>....>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<.<<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>..<<.<<<<<.......<<<<<<<<<.......>>>>>>>>.>........>>>>>....>>.<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>.>..........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>.............>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<.<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<...<<....>>..>>>>>>>>>...>>>>>>>>>>>>..>>>.>>.>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((..(............)...)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....(((.((..((....)))).))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(.(((((.(((((((((.......((((((.....)))))).....)))))))..))))))).)..(((((((((....(((((((....(((((((...((........))......)))))))....).......((....)).))))))...))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((.(..((((((((((......((........))..........(((((((..(...(((((((...((((((....)))))).....(.....)..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..).))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.(.((.(((..((((((((((((....(((((..((....((....))...)).)))))...))))))))))))..))).)).)..).))...)..)..(((((((((....)))))))))}........... ArfB Rescue of a 70S Ribosome stalled on truncated mRNA with a partial A-site codon (+2-II); 16S ribosomal RNA 7jss 1 2903 3.7 RF02540,RF02541 URS0000BC4674_83333 33144582 0003735 0005840 83333 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ArfB Rescue of a 70S Ribosome stalled on truncated mRNA with a partial A-site codon (+2-II); 23S ribosomal RNA 7jss 2 120 3.7 RF00001 URS00008116C5_83333 33144582 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((.(((((...))))).)).......))...)))))))))). ArfB Rescue of a 70S Ribosome stalled on truncated mRNA with a partial A-site codon (+2-II); 5S ribosomal RNA 7jss 5 77 3.7 RF00005 URS000041AF00_83333 33144582 0030533 0006412 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(((((.......)))))))))))..... ArfB Rescue of a 70S Ribosome stalled on truncated mRNA with a partial A-site codon (+2-II); tRNAfMet 7jss 4 16 3.7 33144582 83333 aggagguaaaaaugaa ................ ................ ArfB Rescue of a 70S Ribosome stalled on truncated mRNA with a partial A-site codon (+2-II); mRNA 7jsw 3 1539 3.8 RF00177,RF01959,RF01960 URS00021ED9C1_83333 33144582 0003735 0005840 83333 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggcgaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<...<.........>.....>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<........<<<<<<<<.......>>>>>>>>..........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<..<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>....<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<........<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>.............>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>......>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<..<.<<<<<<<........>>>>>>>>...>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<.<<.<<<..<<<<<<<<<<<<....<<<<.<.<<<...<<....>>..>>>>.>>>>...>>>>>>>>>>>>..>>>.>>.>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..(..((..(((..(............)...)))))...))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..(......))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....(((.((((.......)))).))).....)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(.....(((((..(((((((....))))))).............)))))...).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...((((((......(((..((...(((....)))...))....)))......))))))...........(((((((........))))))).......)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.(.((..((..((((((((((((....(((((..(((...((....))..))).)))))...))))))))))))..))..)).)..).))...)..)..(((((((((....)))))))))}........... ArfB Rescue of a 70S Ribosome stalled on truncated mRNA with a partial A-site codon (+2-III); 16S ribosomal RNA 7jsw 1 2903 3.8 RF02540,RF02541 URS0000BC4674_83333 33144582 0003735 0005840 83333 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ArfB Rescue of a 70S Ribosome stalled on truncated mRNA with a partial A-site codon (+2-III); 23S ribosomal RNA 7jsw 2 120 3.8 RF00001 URS00008116C5_83333 33144582 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. (.((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))).). ArfB Rescue of a 70S Ribosome stalled on truncated mRNA with a partial A-site codon (+2-III); 5S ribosomal RNA 7jsw 5 77 3.8 RF00005 URS000041AF00_83333 33144582 0030533 0006412 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(((((.......)))))))))))..... ArfB Rescue of a 70S Ribosome stalled on truncated mRNA with a partial A-site codon (+2-III); tRNAfMet 7jsw 4 16 3.8 33144582 83333 aggagguaaaaaugaa ................ ................ ArfB Rescue of a 70S Ribosome stalled on truncated mRNA with a partial A-site codon (+2-III); mRNA 7jsz 3 1539 3.7 RF00177,RF01959,RF01960 URS00021ED9C1_83333 33144582 0003735 0005840 83333 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggcgaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<..<<<.......>.>>...>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<..<<...<<<<<<......>>>>>.>....>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<.<<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>..<<.<<<<<.......<<<<<<<<<.......>>>>>>>>.>........>>>>>....>>.<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>.>..........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<.......<<<<<<..<<<<.<......>.>>>>.............>>>>>.>..<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<.<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<...<<....>>..>>>>>>>>>...>>>>>>>>>>>>..>>>.>>.>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((..(............)...)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((.(....).))))......)).).....(((....)))....((((((..(......))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....(((.((((.......)))).))).....)....)))))....)).((((([[[...(((((.....((.]]])).<.....))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.(((((((((.......((((((.....)))))).....)))))))..)))))))))..(((((((((....(((((((....(((((((...((........))......)))))))....).......((....)).))))))...))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...((.(((....))).))..............))))).))).((.(((.>.((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.(.((.(((..(((((((.((((....(((((..((....((....))...)).)))))...)))).)))))))..))).)).)..).))...)..)..(((((((((....)))))))))}........... ArfB Rescue of a 70S Ribosome stalled on truncated mRNA with a partial A-site codon (+2-IV); 16S ribosomal RNA 7jsz 1 2903 3.7 RF02540,RF02541 URS0000BC4674_83333 33144582 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugucgaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<.))).....>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((...<<<.....<.<.<<<<<<<<<<.<<<....<<<........>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>.>>...>>>.........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<<..>>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<.........>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<.........>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<.<<......>>.>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<.<.<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>..>>>>>...>><..<<<<......>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<..<<....>>...>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<..<<<............<<<..............<<<.<<......>>.>>>.....................>>>...>>>..>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<.)))..>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<.........>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((.......(((((((((.((.(((...(((((......)))))[[......(((.....]])))...)))...)).)))))))))....))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...).)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((..((.......))...))...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(.(.........).)..))).....(...((......)).).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((..((......))..))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((...(((...(((....)))...)))...)))..(((((........)))))]]((((((((((.((...((((....((((..(((..(((((.(((((....{{{...))))).((..((((...(((.(..(((((.((.....)))))))..)...)))..[))))...))(..(((.(....).)))...))))))...)))...))))(..).....))))...)).....)))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((...((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((((((((..((..............((.(............(.(............).)...................).)).....))..))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). ArfB Rescue of a 70S Ribosome stalled on truncated mRNA with a partial A-site codon (+2-IV); 23S ribosomal RNA 7jsz 2 120 3.7 RF00001 URS00008116C5_83333 33144582 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa .<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>.. (.((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))).). ArfB Rescue of a 70S Ribosome stalled on truncated mRNA with a partial A-site codon (+2-IV); 5S ribosomal RNA 7jsz 5 77 3.7 RF00005 URS000041AF00_83333 33144582 0030533 0006412 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(((((.......)))))))))))..... ArfB Rescue of a 70S Ribosome stalled on truncated mRNA with a partial A-site codon (+2-IV); tRNAfMet 7jsz 4 16 3.7 33144582 83333 aggagguaaaaaugaa ................ ................ ArfB Rescue of a 70S Ribosome stalled on truncated mRNA with a partial A-site codon (+2-IV); mRNA 7jt1 3 1539 3.3 RF00177,RF01959,RF01960 URS00021ED9C1_83333 33144582 0003735 0005840 83333 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggcgaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<.<<<<........>>>>..>>>.>..>>>>>......<<..<....<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>>>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>..<<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>>.<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<.<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>.>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((..((..........))...)))))..)))))......(((......(((((((..((...(.(((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).))))).)..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..(((.......((((....))))......)))..((.(((((...(....(((.((((.......)))).))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.(((((((((.......((((((.....)))))).....)))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((...((.(((....))).))..............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....))))))))..)).)))))))).....(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....).....))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.(.((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).)).)..).))...)..)..(((((((((....)))))))))}........... 70S ribosome stalled on long mRNA with ArfB-1 and ArfB-2 bound (+9-III); 16S ribosomal RNA 7jt1 1 2903 3.3 RF02540,RF02541 URS0000BC4674_83333 33144582 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugucgaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<....<.<<<<<<<<<<<<<.<<<....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>..>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<.......>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<....<<.........>.>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<............>>>>>....>>>>>><<<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>.>>.....>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<.<.<<<...<<<....>>>...>>>..>>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>.>......>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<..<<<<.............<<<...<............<<<....>>>.........>.............>>>....>>>>..>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. (.((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......((((.((((((((.(((...(((((......)))))[[......(((.....]])))...)))...)))))))).))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...).)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((.(((.......)))..))...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(.(((..(((.....{.(((((.(((..(.(.........).)..))).....(...((......)).).)))))...)))..))).).))...........]]].)...))))))))))...)))))))((((...(......)...))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]]((((((((((.((...((((....((((..(((..(((((((((((....{{{...))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..(((.(....).)))...))))))...)))...))))(..).....))))...)).....)))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((....(((....])))....)))...))))))(...).......(((((((((...((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..(((.((((.(((.((......((((.((((((..(((((.(((.(((((.((((((((((..((..............(..(............(.(.((......)).).)...................)..).....))..))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....))..))))))).)))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))).). 70S ribosome stalled on long mRNA with ArfB-1 and ArfB-2 bound (+9-III); 23S ribosomal RNA 7jt1 2 120 3.3 RF00001 URS00008116C5_83333 33144582 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa .<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>.. (.((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((.(((((...))))).)).......))...)))))))).). 70S ribosome stalled on long mRNA with ArfB-1 and ArfB-2 bound (+9-III); 5S ribosomal RNA 7jt1 5 77 3.3 RF00005 URS000041AF00_83333 33144582 0030533 0006412 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... 70S ribosome stalled on long mRNA with ArfB-1 and ArfB-2 bound (+9-III); tRNAfMet 7jt1 4 20 3.3 33144582 83333 aggagguaaaaauguaaaaa .................... .................... 70S ribosome stalled on long mRNA with ArfB-1 and ArfB-2 bound (+9-III); mRNA 7jt2 3 1539 3.5 RF00177,RF01959,RF01960 URS00021ED9C1_83333 33144582 0003735 0005840 83333 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggcgaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<.<<<<<......>>>>>..>>>.>..>>>>>......<<..<....<<<<<<<..<<...<<<<<<<.<.<.<....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<...<<<<<<.........>>>>>>.>>>......>>>..<<<<<<<<....>>>>...>>>>>>>.<<<<.<<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>..<<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>>.<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<.......<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>..<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<.<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>.>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((..(.(........).)...)))))..)))))......(((......(((((((..((...(.(((((.(.((.....((((.(....).))))......)).).....(((....)))....((((((..((....)))))))).))))).)..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....(((.((((.......)))).))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.(((((((((.......((((((.....)))))).....)))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((..(((.(((....))).))).............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....))))))))..)).)))))))).....((((((......(((..((...(((....)))...))....)))......))))))......(....(((((((........)))))))....).....))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.(.((.(((..((((((..((((....((((((.((((..((....)).))))))))))...))))..))))))..))).)).)..).))...)..)..(((((((((....)))))))))}........... 70S ribosome stalled on long mRNA with ArfB bound in the A site; 16S ribosomal RNA 7jt2 1 2903 3.5 RF02540,RF02541 URS0000BC4674_83333 33144582 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugucgaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<....<<<........>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<<<<..>>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<.......>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<....<<.........>.>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<............>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.......<<<<<..<<....>>...>>>>>.......>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<..<<<<.............<<<..<<<...........<<<....>>>........>>>............>>>....>>>>..>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<.<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>...>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. (.((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......((((.((((((((.(((...(((((......)))))[[......(((.....]])))...)))...)))))))).))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...).)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...((..((((...((.(((.......)))..))...))))..))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((....(.........)....))).....(...((......)).).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((..(......)..)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]]((((((((((.((...((((....((((..(((..(((((((((((....{{{...))))))((...(((...(((((.((((((.((.....)))))))).)..))))..[)))....))(..(((((....)))))...))))))...)))...))))(..).....))))...)).....)))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((....(((....])))....)))...))))))(...).......(((((((((...((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((.((..(...............(..(..(.........(.(.(((....))).).)......)............)..)......)..)).)))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(..((((.....)))).(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))).). 70S ribosome stalled on long mRNA with ArfB bound in the A site; 23S ribosomal RNA 7jt2 2 120 3.5 RF00001 URS00008116C5_83333 33144582 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa .<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>.. (.((((((((.....((.(((((....(((((((...(.....)...))))..)))...)))))..)).((.......((((((((...)))))))).......))...)))))))).). 70S ribosome stalled on long mRNA with ArfB bound in the A site; 5S ribosomal RNA 7jt2 5 77 3.5 RF00005 URS000041AF00_83333 33144582 0030533 0006412 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... 70S ribosome stalled on long mRNA with ArfB bound in the A site; tRNAfMet 7jt2 4 21 3.5 33144582 83333 aggagguaaaaauguaaaaaa ..................... ..................... 70S ribosome stalled on long mRNA with ArfB bound in the A site; mRNA 7jt3 3 1539 3.7 RF00177,RF01959,RF01960 URS00021ED9C1_83333 33144582 0003735 0005840 83333 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggcgaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<.<<<<<......>>>>>..>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<..<<...<<<<<<......>>>>>.>....>>.>.....<<<....>>>....<<<<<.<.<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<.......<<<....>>>......>>>>..<<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>>.<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>..>>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>.>..........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<.....>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).].<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<.......<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>..<<<.<<...<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>.>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>.....<..<<.<.<.<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<...<<....>>..>>>>>>>>>...>>>>>>>>>>>>..>>>.>>.>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((....[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((..(............)...)))))..)))))......(((......(((((((..((...(.(((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).))))).)..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....(((.((((.......)))).))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(.(((((.(((((((((.......((((((.....)))))).....)))))))..))))))).)..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]]..(((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((..(((((((....))))))).............))))).))).((.((....((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...))..))))....))))))))..)).)))))))).....(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....).....))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((...(.((.(((..((((((((((((....(((((..((....((....))...)).)))))...))))))))))))..))).)).)....))...)..)..(((((((((....)))))))))}........... Rotated 70S ribosome stalled on long mRNA with ArfB-1 and ArfB-2 bound in the A site (+9-IV); 16S ribosomal RNA 7jt3 1 2903 3.7 RF02540,RF02541 URS0000BC4674_83333 33144582 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugucgaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<....<<<.<.....>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<.<...<<<.<<<<...<<<<<<<.....>>>>>.>>...>>>>.>>>..>..>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<....<<.........>.>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<.<<......>>.>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>.>........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.......<<<<<..<<....>>...>>>>>.......>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<..<<<<.............<<<..<<<........<<.<<<....>>>.>>.....>>>............>>>....>>>>..>>>>>>>>>>...<<<.<<<<<.......>>>>>>>>....>>>>>.>>>..>>>>>..<<<.......>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<.)))..>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. (.((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....(((((((..(((]]]..].)))......)))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((.......(((((((((.((.(((...(((((......)))))[[......(((.....]])))...)))...)).)))))))))....))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...).)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((.(((.......)))..))...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(.(((..(((.....{.(((((.(((..(.(.........).)..))).....(...((......)).).)))))...)))..))).).))...........]]].)...))))))))))...)))))))((((...(......)...))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((...(((...(((....)))...)))...)))..(((((........)))))]]((((((((((.((...((((....((((..(((..(((((.(((((....{{{...))))).((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((.(....).)))...))))))...)))...))))(..).....))))...)).....)))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((....(((....])))....)))...))))))(...).......(((((((((...((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((((((((..((..............(..(............(.(.((......)).).)...................)..).....))..))))))))))...((..((((((.....)))))).))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....((.((((.((..]]]]..)))))).)).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))).). Rotated 70S ribosome stalled on long mRNA with ArfB-1 and ArfB-2 bound in the A site (+9-IV); 23S ribosomal RNA 7jt3 2 120 3.7 RF00001 URS00008116C5_83333 33144582 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa .<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>.. (.((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))).). Rotated 70S ribosome stalled on long mRNA with ArfB-1 and ArfB-2 bound in the A site (+9-IV); 5S ribosomal RNA 7jt3 5 76 3.7 RF00005 URS000041AF00_83333 33144582 0030533 0006412 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacc .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>.>....<<<<.........>>>>>>>>>>.... .((((((..((((.........)))).(((((.......))))).....(((((.......))))))))))).... Rotated 70S ribosome stalled on long mRNA with ArfB-1 and ArfB-2 bound in the A site (+9-IV); tRNAfMet 7jt3 4 14 3.7 33144582 83333 aggagguaaaaaug .............. .............. Rotated 70S ribosome stalled on long mRNA with ArfB-1 and ArfB-2 bound in the A site (+9-IV); mRNA 7k00 A 1519 1.98 RF00177,RF01959,RF01960 URS00000ABFE9_562 32924932 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugccggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<..<<<<<<<<........>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<.>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>...<.<<<<<.......<<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<..>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((.(........).))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((.)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((((())))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...((((((....))))))..............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Structure of the Bacterial Ribosome at 2 Angstrom Resolution; 16S rRNA 7k00 a 2753 1.98 RF02540,RF02541 URS00004B0F34_562 32924932 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagcgucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcgcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<................>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<..>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<<.<<....>>..>>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<..>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......((((.((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))).))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((((((.....))))).))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{..()....)))..))))).))...........]]].)...))))))))))...)))))))((((.(((()))).))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....((((.((((((.((.....)))))))).)..)))...[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((())))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).).....((.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..))....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Structure of the Bacterial Ribosome at 2 Angstrom Resolution; 23S rRNA 7k00 b 119 1.98 RF00001 URS0000049E57_562 32924932 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>> ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))) Structure of the Bacterial Ribosome at 2 Angstrom Resolution; 5S rRNA 7k00 X 12 1.98 32924932 562 aaaaugguauaa ............ ............ Structure of the Bacterial Ribosome at 2 Angstrom Resolution; mRNA 7k00 Y 74 1.98 RF00005 URS000009F4BF_562 32924932 0030533 0006412 562 gggugauuagcucaggggagagcaccucccuuacaaggagggggucggcgguucgaucccgucaucacccacca <<<<<<<..<<<<......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..(((....[...))).(((((.......))))).....(.(((..]....))).)))))))).... Structure of the Bacterial Ribosome at 2 Angstrom Resolution; A-site tRNA-val 7k00 Z 76 1.98 RF00005 URS00002905B5_562 32924932 0030533 0006412 562 gcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Structure of the Bacterial Ribosome at 2 Angstrom Resolution; P-site tRNA-fMet 7k50 3 1539 3.4 RF00177,RF01959,RF01960 URS000080DDC0_83333 34330903 0003735 0005840 83333 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<.<<<<.<<....>>.>>>>..>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<.<.<......>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<...<<<<<<.........>>>>>>.>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>..<<.<<<<<........<<<<<<<<.......>>>>>>>>..........>>>>>....>>.<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>.............>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((..(............)...)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..(......))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((.(.((((((((((......((((((.....))))))....))))))))..))).)))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...((((((....)))))).....(....)...))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Pre-translocation non-frameshifting(CCA-A) complex (Structure I); 16S ribosomal RNA 7k50 1 2903 3.4 RF02540,RF02541 URS0000BC4674_83333 34330903 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugucgaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<....<.<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>..>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<<.....>>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<....<<<.........>>>....>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>.>........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<..<<....>>...>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<..<<<.<<<<<.<<<<<<<<.<<.<.<<...........<<<.....<<......<<.<<<<<....>>>>>.>>...>>...............>>>..>>.>.>>.>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>...>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......((((.(((((.((.(((...(((((......)))))[[......(((.....]])))...)))...)).))))).))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((((..)))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...).)))...(((.(((((........))))))))..).))))))))).(.((.......))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((.((.......)).).))...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(.(.....{.(((((.(((..(.(.........).)..))).....(..(((......)))).)))))...).)..))))).))...........]]].)...))))))))))...)))))))((((((.(......).))))))....))))))(((((((...(((......((((((((....))))))))...)))..))))).)).....))))))(......((.....((((((.......))))))((((....((((..((..(((((.(...((.....)).).))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..(((((.(((((....{{{...))))).((..(((....((((((((((((.((.....))))))))))..))))..[.)))...))(..(((.(....).)))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((...((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((((.((((.(...............((.(............(..(((......)))..)............(..)...).))......).)))).))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((.....((((....))))....))...))))).))).....))..).))))))))). Pre-translocation non-frameshifting(CCA-A) complex (Structure I); 23S ribosomal RNA 7k50 2 120 3.4 RF00001 URS00008116C5_83333 34330903 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((.(.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((.(((((...))))).)).......))...).)))))))). Pre-translocation non-frameshifting(CCA-A) complex (Structure I); 5S ribosomal RNA 7k50 5 77 3.4 RF00005 URS000041AF00_83333 34330903 0030533 0006412 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Pre-translocation non-frameshifting(CCA-A) complex (Structure I); tRNAfMet 7k50 6 77 3.4 RF00005 URS000041AF00_83333 34330903 0030533 0006412 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>........<<.......>>...>>>>>>..... .((((((..((((.........)))).(((((.......)))))........((.......))...))))))..... Pre-translocation non-frameshifting(CCA-A) complex (Structure I); tRNAfMet 7k50 4 18 3.4 34330903 83333 aggagguaaaaaugccaa .................. .................. Pre-translocation non-frameshifting(CCA-A) complex (Structure I); mRNA 7k50 7 77 3.4 RF00005 URS00002E063F_83333 34330903 0030533 0006412 83333 cggcgaguagcgcagcuugguagcgcaacugguuugggaccagugggucggagguucgaauccucucucgccgacca <<<<<<<..<<<<.........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((......[..)))).(((((.......)))))......((((..]....)))).))))))).... Pre-translocation non-frameshifting(CCA-A) complex (Structure I); tRNAPro 7k51 3 1539 3.5 RF00177,RF01959,RF01960 URS000080DDC0_83333 34330903 0003735 0005840 83333 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<...[((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<...<<..<<.<...<<<<<<............>>>.>>>.>..>>>>.......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<.......<<<....>>>......>>>>...<.<<<<<.......<<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<....<.<<<<<<.....>>>>>>.>..>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<.<<<<<<<<<<<......<<........>>..........<<<<<<<.......<<<<<<..<<<<<<......>>>>>>.............>>>>>.>..<<<.<<<..<<<<<<..<....<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<..<<<<<.....<...<<<.....>>>.>......>>>>>.....<<<<<.....>>>>>.........>>>.....>...>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.>...<<<<<<<.....<<<..<....<<<....>>>....>....>>>.....>>>>>>>......<.....<<<<<..........>>>>>.....>.....>>>>>>.....<<<<<<.........>>>>>>.......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((..(............)...)))))..)))))......(((.......((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..(......))))))).)))))))..)).)))))).(((....((...((((((.(.......).)))))).))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......(.((....)).).....))))...(.(((((...(....((((((((.......)))))))).....)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((....(((((((....(((((((...((........))......)))))))....).......((....)).))))))...))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((..(((((.....)))))..)))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...((((((....))))))..............))))).))).((.((....((((((.(....(((((((((....)))...(((......)))...)))))).....((.(.(((((.(...((..(((.....)))))....).)))))..(..((((.......)))).....)..).)).....).).)))...))..))))....)))))))...)).)))))))).(...((((((......(((..((...(((....)))...))....)))......))))))......(.....((((((........)))))).....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((.((((....((((((.((((..((....)).))))))))))...)))).)))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Mid-translocated non-frameshifting(CCA-A) complex with EF-G and GDPCP (Structure II); 16S ribosomal RNA 7k51 1 2903 3.5 RF02540,RF02541 URS0000BC4674_83333 34330903 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugucgaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>...[.....<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<....<.<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>..>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))....].]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<.......>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<.........>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<..<......>..>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>.>........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<<.<<....>>..>>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<..............<<<.............<<..<<<<....>>>>..>>....................>>>.....>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((.......(((((((((.((.(((...(((((......)))))[[......(((.....]])))...)))...)).)))))))))....))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...).)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((.(((.......)))..))...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(.(.....{.(((((.(((..(.(.........).)..))).....(..(((......)))).)))))...).)..))))).))...........]]].)...))))))))))...)))))))(((((..(......)..)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((...(((...(((....)))...)))...)))..(((((........)))))]]((((((((((.((...((((....((((..(((..(((((((((((....{{{...))))))((..((((...(((((.((((((.((.....)))))))).)..))))..[))))...))(..(((.(....).)))...))))))...)))...))))(..).....))))...)).....)))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((....(((....])))....)))...))))))(...).......(((((((((...((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..(((.((((.(((.((......((((.((((((..(((((.(((.(((((.((((((((((..(...............(..(............(.(..(......)..).)...................)..)......)..))))))))))...(((..(((((.....))))).)))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....((.((((.((..]]]]..)))))).)).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((.(((..(((((((((......))))))..))).(((((.....))))).....))).)..)...))..).....(((((((....))).))))....))..))))))).)))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Mid-translocated non-frameshifting(CCA-A) complex with EF-G and GDPCP (Structure II); 23S ribosomal RNA 7k51 2 120 3.5 RF00001 URS00008116C5_83333 34330903 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Mid-translocated non-frameshifting(CCA-A) complex with EF-G and GDPCP (Structure II); 5S ribosomal RNA 7k51 5 77 3.5 RF00005 URS00002E063F_83333 34330903 0030533 0006412 83333 cggcgaguagcgcagcuugguagcgcaacugguuugggaccagugggucggagguucgaauccucucucgccgacca .<<<<<<..<<<<.........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......)))))......((((..]....)))).))))))..... Mid-translocated non-frameshifting(CCA-A) complex with EF-G and GDPCP (Structure II); tRNAPro 7k51 6 77 3.5 RF00005 URS000041AF00_83333 34330903 0030533 0006412 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>.>....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(((((.......)))))))))))..... Mid-translocated non-frameshifting(CCA-A) complex with EF-G and GDPCP (Structure II); tRNAfMet 7k51 4 16 3.5 34330903 83333 agguaaaaaugccaag ................ ................ Mid-translocated non-frameshifting(CCA-A) complex with EF-G and GDPCP (Structure II); mRNA 7k52 3 1539 3.4 RF00177,RF01959,RF01960 URS000080DDC0_83333 34330903 0003735 0005840 83333 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<......<<<.<<<..<<<..<<.<<..<<.<<<<.<<....>>.>>>>..>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<..<..<<<<<......>>>>>.....>>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<...<<<<<<.........>>>>>>.>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>...>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<.......<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>..<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>.....<<<<<<.........>>>>>>.......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((.((...(....)...))..)))))..)))))......(((.......((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......(((.((.....)).)))....))))))))..)))))))))..(((((((((....(((((((....(((((((...((........))......)))))))....).......((....)).))))))...))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((.(((((......((........))..........(((((((..(...(((((((...((((((....))))))..............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....(((..(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)...))).....).).)))...)).)))))....)))))))...)).))).)))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((....((....))...))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Near post-translocated non-frameshifting(CCA-A) complex with EF-G and GDPCP (Structure III); 16S ribosomal RNA 7k52 1 2903 3.4 RF02540,RF02541 URS0000BC4674_83333 34330903 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugucgaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<....<.<<<<<<<<<<<<<.<<<....<<<........>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>..>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<.......>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<.........>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<............>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>.>........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<..<<....>>...>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<<<<<..<<.......<<<<<<<<....>>>>>>>>....>>............>>>>>...>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[......(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.(.((..(((((((..)))))))..)).).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...).)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((.(((.......)))..))...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(.(.........).)..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((..(......)..)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..(((((((((((....{{{...))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((....(((....])))....)))...))))))(...).......(((((((((...((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..((((..(((.(((((.((((((((((..((((.(..........((.(............(((..(......)..)))...................).)).).))))..))))))))))...(((..(((((.....))))).)))....))))).)))...))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Near post-translocated non-frameshifting(CCA-A) complex with EF-G and GDPCP (Structure III); 23S ribosomal RNA 7k52 2 120 3.4 RF00001 URS00008116C5_83333 34330903 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa .<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.....<.<<<<<<<<...>>>>>>>>...>...>>...>>>>>>>>>.. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((.(((((...))))).)).......))...)))))))))). Near post-translocated non-frameshifting(CCA-A) complex with EF-G and GDPCP (Structure III); 5S ribosomal RNA 7k52 5 77 3.4 RF00005 URS00002E063F_83333 34330903 0030533 0006412 83333 cggcgaguagcgcagcuugguagcgcaacugguuugggaccagugggucggagguucgaauccucucucgccgacca <<<<<<<..<<<<.........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((......[..)))).(((((.......)))))......((((..]....)))).))))))).... Near post-translocated non-frameshifting(CCA-A) complex with EF-G and GDPCP (Structure III); tRNAPro 7k52 6 77 3.4 RF00005 URS000041AF00_83333 34330903 0030533 0006412 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<.<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>.>..... .((((((..((.(......[..).)).(((((.......))))).....(((((..]....)))))))))))..... Near post-translocated non-frameshifting(CCA-A) complex with EF-G and GDPCP (Structure III); tRNAfMet 7k52 4 16 3.4 34330903 83333 agguaaaaaugccaag ................ ................ Near post-translocated non-frameshifting(CCA-A) complex with EF-G and GDPCP (Structure III); mRNA 7k53 3 1539 3.2 RF00177,RF01959,RF01960 URS000080DDC0_83333 34330903 0003735 0005840 83333 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<.<<<<.<<....>>.>>>>..>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<.<.<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<.<<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>..<<.<<<<<........<<<<<<<<.......>>>>>>>>..........>>>>>....>>.<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((.((..((....))..))..)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..(......))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((..(((((((....))))))).............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....))))))))..)).)))))))).(...(.(((((.....(((..((...(((....)))...))....))).....))))).)......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Pre-translocation +1-frameshifting(CCC-A) complex (Structure I-FS); 16S ribosomal RNA 7k53 1 2903 3.2 RF02540,RF02541 URS0000BC4674_83333 34330903 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugucgaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<....<.<<<<<<<<<<<<<.<<<....<<<<......>>>>.((......<<<.....))>>>...>>>.>..>>>>>>>>>>>>>..>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<<.....>>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<....<<.........>>....>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<............>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>.>........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<..<<.......<<<<<<<<....>>>>>>>>....>>............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......((((.((((((((.(((...(((((......)))))[[......(((.....]])))...)))...)))))))).))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...((..((((...((.(((.......)))..))...))))..))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(.(.........).)..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((..(......)..)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..(((((((((((....{{{...))))))(...((((...((((((((((((.((.....))))))))))..))))..[))))....)(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((((((((..((.(.(.........((..(............((((.(......).))))...................)..))).).))..))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....((.((((.((..]]]]..)))))).)).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Pre-translocation +1-frameshifting(CCC-A) complex (Structure I-FS); 23S ribosomal RNA 7k53 2 120 3.2 RF00001 URS00008116C5_83333 34330903 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Pre-translocation +1-frameshifting(CCC-A) complex (Structure I-FS); 5S ribosomal RNA 7k53 5 77 3.2 RF00005 URS000041AF00_83333 34330903 0030533 0006412 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Pre-translocation +1-frameshifting(CCC-A) complex (Structure I-FS); tRNAfMet 7k53 6 77 3.2 RF00005 URS000041AF00_83333 34330903 0030533 0006412 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>.>....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).......(((.......)))..))))))..... Pre-translocation +1-frameshifting(CCC-A) complex (Structure I-FS); tRNAfMet 7k53 4 18 3.2 34330903 83333 aggagguaaaaaugccca .................. .................. Pre-translocation +1-frameshifting(CCC-A) complex (Structure I-FS); mRNA 7k53 7 77 3.2 RF00005 URS00002E063F_83333 34330903 0030533 0006412 83333 cggcgaguagcgcagcuugguagcgcaacugguuugggaccagugggucggagguucgaauccucucucgccgacca <<<<<<<..<<<<.........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((......[..)))).(((((.......)))))......((((..]....)))).))))))).... Pre-translocation +1-frameshifting(CCC-A) complex (Structure I-FS); tRNAPro 7k54 3 1539 3.2 RF00177,RF01959,RF01960 URS000080DDC0_83333 34330903 0003735 0005840 83333 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<...[((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<.<<....>>.>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<.<.<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<...<<<<<<....<...<<<.....>>>.>.....>>>>>>.....<<<.........>>>..........>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((....[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((.((...(....)...))..)))))..)))))......(((.......((((((..((...(((((((.(.((.....((((........))))......)).).....(((....)))....((((((..(......))))))).)))))))..)).)))))).(((....(((..((((((((.......)))))))))))......)))..((((.(((....)))....))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(...(((((((((.......)))))))).)...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((....(((((((....(((((((...((........))......)))))))....).......((....)).))))))...))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]]..(((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....))))))).............))))).))).((.((....((((((.(....(((((((((....)))...(((......)))...)))))).....((.(.(((((.(...((..(((.....)))))....).)))))..(..((((.......)))).....)..).)).....).).)))...))..))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((....((....))...))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Mid-translocated +1-frameshifting(CCC-A) complex with EF-G and GDPCP (Structure II-FS); 16S ribosomal RNA 7k54 1 2903 3.2 RF02540,RF02541 URS0000BC4674_83333 34330903 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugucgaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>...[.....<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<....<.<<<<<<<<<<<<<.<<<....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>..>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))....].]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<<..>>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<.........>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<............>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>.>......>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<<<<<..<<.......<<<<<<<<....>>>>>>>>....>>............>>>>>...>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<.........>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......((((.((((((((.(((...(((((......)))))[[......(((.....]])))...)))...)))))))).))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((((..)))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((..(((.....)))...))...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(.(.........).)..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((..(......)..)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((...(((...(((....)))...)))...)))..(((((........)))))]](((((((((((((...((((....((((..(((..(((((.(((((....{{{...))))).((...(((...(((((.((((((.((.....)))))))).)..))))..[)))....))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(.(((.........))).)........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.((..(((((.(((((((((((.(.((............(..(............(.((.(......).)).)...................)..)...)).).)))))))))))...(((.((((((.....)))))))))....)))))..))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Mid-translocated +1-frameshifting(CCC-A) complex with EF-G and GDPCP (Structure II-FS); 23S ribosomal RNA 7k54 2 120 3.2 RF00001 URS00008116C5_83333 34330903 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((.(((((...))))).)).......))...)))))))))). Mid-translocated +1-frameshifting(CCC-A) complex with EF-G and GDPCP (Structure II-FS); 5S ribosomal RNA 7k54 5 77 3.2 RF00005 URS00002E063F_83333 34330903 0030533 0006412 83333 cggcgaguagcgcagcuugguagcgcaacugguuugggaccagugggucggagguucgaauccucucucgccgacca <<<<<<<..<<<<.........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((......[..)))).(((((.......)))))......((((..]....)))).))))))).... Mid-translocated +1-frameshifting(CCC-A) complex with EF-G and GDPCP (Structure II-FS); tRNAPro 7k54 6 77 3.2 RF00005 URS000041AF00_83333 34330903 0030533 0006412 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Mid-translocated +1-frameshifting(CCC-A) complex with EF-G and GDPCP (Structure II-FS); tRNAfMet 7k54 4 16 3.2 34330903 83333 agguaaaaaugcccag ................ ................ Mid-translocated +1-frameshifting(CCC-A) complex with EF-G and GDPCP (Structure II-FS); mRNA 7k55 3 1539 3.3 RF00177,RF01959,RF01960 URS000080DDC0_83333 34330903 0003735 0005840 83333 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<......<<<.<<<..<<<..<<.<<..<<<.<<<<<<....>>>>>>..>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<..<..<<<<<......>>>>>.....>>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<...<<<<<<.........>>>>>>.>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>...>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<....<<<....>>>....>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((.((.(........).))..)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....))).....(((((..((....)))))))..)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..(((((((......)))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......(.((....)).).....))))...(.(((((...(....(((((.((.......)).))))).....)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((....(((((((....(((((((...((........))......)))))))....).......((....)).))))))...))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((.((((((.....)))))).)))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...((((((....)))))).....(....)...))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((....((....))...))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Near post-translocated +1-frameshifting(CCC-A) complex with EF-G and GDPCP (Structure III-FS); 16S ribosomal RNA 7k55 1 2903 3.3 RF02540,RF02541 URS0000BC4674_83333 34330903 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugucgaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<<..>>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<.......>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<......<.<<<<<.<<...<<<.........>>>...>>........<<<......>>>..>>>>>.>..>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<............>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>.>........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<................<<<<<..<<........<<<<<<......>>>>>>.....>>............>>>>>.......>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((.......((((((((.(((.(((...(((((......)))))[[......(((.....]])))...)))...))).))))))))....))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((((..)))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))..(((((((..((((((((((.....(((...(((.((((...((.(((.......)))..))...)))).)))..)).).....)))))).)))..)))))))).....((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(.((.......)).)..))).....(...((......)).).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((..(......)..)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..(((((((((((....{{{...))))))((...(((...((((((((((((.((.....))))))))))..))))..[)))....))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((....(((....])))....)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((...(...............(..(...((.......(((..(......)..)))....)).............)..)......)...)))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Near post-translocated +1-frameshifting(CCC-A) complex with EF-G and GDPCP (Structure III-FS); 23S ribosomal RNA 7k55 2 120 3.3 RF00001 URS00008116C5_83333 34330903 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa .<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>.. .(((((((.(.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...).))))))).. Near post-translocated +1-frameshifting(CCC-A) complex with EF-G and GDPCP (Structure III-FS); 5S ribosomal RNA 7k55 5 77 3.3 RF00005 URS00002E063F_83333 34330903 0030533 0006412 83333 cggcgaguagcgcagcuugguagcgcaacugguuugggaccagugggucggagguucgaauccucucucgccgacca <<<<<<<..<<<<.........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... .((((((..((((......[..)))).(((((.......)))))......((((..]....)))).))))))..... Near post-translocated +1-frameshifting(CCC-A) complex with EF-G and GDPCP (Structure III-FS); tRNAPro 7k55 6 77 3.3 RF00005 URS000041AF00_83333 34330903 0030533 0006412 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<.........>>>>>>>>>>..... .((((((..((.(......[..).)).(((((.......))))).....(((((..]....)))))))))))..... Near post-translocated +1-frameshifting(CCC-A) complex with EF-G and GDPCP (Structure III-FS); tRNAfMet 7k55 4 16 3.3 34330903 83333 agguaaaaaugcccag ................ ................ Near post-translocated +1-frameshifting(CCC-A) complex with EF-G and GDPCP (Structure III-FS); mRNA 7kfn B 23 2.5 URS0000A7634A_9606 33939417 9606 gcucgcgaugcungagggcucug ....................... ....................... Structure of Human Adenosine Deaminase Acting on dsRNA (ADAR2) bound to dsRNA containing a 2'-deoxy Benner's Base Z opposite the edited base; Gli1 8AZ 23mer RNA 7kfn C 23 2.5 URS00023119B7_9606 33939417 9606 cagagcccccnagcaucgcgagc ....................... ....................... Structure of Human Adenosine Deaminase Acting on dsRNA (ADAR2) bound to dsRNA containing a 2'-deoxy Benner's Base Z opposite the edited base; Gli1 1W5 23mer RNA 7kgb A 3118 2.7 RF02540,RF02541,RF00002 URS00005E0FC6_83332 36827973 0003735 0005840 83332 aagugucuaagggcgcaugguggaugccuuggcaucgagagccgaugaaggacgugggaggcugcgauaugccucggggagcugucaaccgagcguggauccgaggauuuccgaauggggaaacccagcacgagugaugucgugcuacccgcaucugaauauauagggugcgggagggaacgcggggaagugaaacaucucaguacccguaggaggagaaaacaauugugauuccgcaaguaguggcgagcgaacgcggaacaggcuaaaccgcacgcauggguaaccggguagggguugugugugcgggguugugggaggauaugucucagcgcuacccggcugagaggcagucagaaagugucgugguuagcggaaguggccugggauggucugccguagacggugagagcccgguacgcgaaaacccggcaccugccuaguaucaauucccgaguagcagcgggcccguggaauccgcugugaauccgccgggaccacccgguaagccuaaauacuccucgaugaccgauagcggauuaguaccgugagggaauggugaaaaguaccccgggaggggagugaaagaguaccugaaaccgugugccuacaauccgucagagccuccuuuuccucuccggaggaggguggugauggcgugccuuuugaagaaugagccugcgagucagggacaugucgcaagguuaacccgugugggguagccgcagcgaaagcgagucugaauagggcgacccacacgcgcauacgcgcgugugaauaguggcguguucuggacccgaagcggagugaucuacccauggccagggugaagcgcggguaagaccgcguggaggcccgaacccacuuagguugaagacugaggggaugagcuguggguaggggugaaaggccaaucaaacuccgugauagcugguucuccccgaaaugcauuuaggugcagcguugcgugguucaccgcggagguagagcuacuggauggccgauggguuacugacgucagccaaacuccgaaugccgugguguaaagcguggcagugagacggcgggggauaagcuccguacgucgaaagggaaacagcccagaucgccggcuaaggcccccaagcgugugcuaagugggaaaggaugugcagucgcaaagacaaccaggagguuggcuuagaagcagccacccuugaaagagugcguaauagcucacuggucaagugauugugcgccgauaauguagcggggcucaagcacaccgccgaagccgcggcacauccaccuugugguggguguggguaggggagcgucccucauucagcgaagccaccgggugaccggugguggagggugggggagugagaaugcaggcaugaguagcgacaaggcaagugagaaccuugcccgccgaaagaccaaggguuccugggccaggccaguccgcccagggugagucgggaccuaaggcgaggccgacaggcguagucgauggacaacggguugauauucccguacccgugugugggcgcccgugacgaaucagcgguacuaaccacccaaaaccggaucgaucacuccccuucggggguguggaguucuggggcugcgugggaacuucgcugguaguagucaagcgaaggggugacgcaggaagguagccguaccagucagugguaacacuggggcaagccgguagggagagcgauaggcaaauccgucgcucacuaauccugagaggugacgcauagccgguugaggcgaauucggugauccucugcugccaagaaaagccucuagcgagcacacacacggcccguaccccaaaccgacacagguggucagguagagcauaccaaggcguacgagauaacuaugguuaaggaacucggcaaaaugcccccguaacuucgggagaagggggaccggaauaucgugaacacccuugcggugggagcgggauccggucgcagaaaccagugaggagcgacuguuuacuaaaaacacagguccgugcgaagucgcaagacgauguauacggacugacgccugcccggugcuggaagguuaagaggacccguuaacccgcaagggugaagcggagaauuuaagccccaguaaacggcggugguaacuauaaccauccuaagguagcgaaanuccuugucggguaaguuccgaccugcacgaauggcguaacgacuucucaacugucucaaccauagacucggcgaaauugcacuacgaguanagaugcucguuacgcgcggcaggacganaagaccccgggaccuucacuacaacuugguauugauguucgguacgguuuguguaggauaggugggagacugugaaaccucgacgccaguuggggcggagucguuguugaaauaccacucugaucguauugggcaucuaaccucgaacccugaaucggguuuagggacagugccuggcggguaguuuaacugnggcgguugccuccuaaaauguaacggaggcgcccaaagguucccucaaccuggacggcaaucagguggcgaguguaaaugcacaagggagcuugacugcgagacuuacaagucaagcagggacgaaagucgggauuagugauccggcacccccgaguggaaggggugucgcucaacggauaaaagguaccccggggauaacaggcugaucuuccccaagaguccauaucgacgggaugguuuggcancucgaugucggcucgucgcauccuggggcuggagcaggucccaaggguugggcunuucgcccauuaaagcggcacgcgagcuggguuuagaacgucgugagacaguucggucucuauccgccgcgcgcgucagaaacuugaggaaaccugucccuaguacgagaggaccgggacggacgaaccucuggugcaccaguugucccgccaggggcaccgcuggauagccacguucggucaggauaaccgcugaaagcaucuaagcgggaaaccuucuccaagaucagguuucucacccacuuggugggauaaggccccccgcagaacacggguucaauaggucagaccuggaagcucaguaauggguguagggaacuggugcuaaccggccgaaaacuu <<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<<......<<<<<<.[[.(((.>>>.....<<<<<<<..<<<)))..]].>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<....<<<<<<<<<<......<<((((((>>...>>>>>>>>>>......<<<<<<<<...<<<<<<<.)))))).>>>>>>><<<<<.......<<<<<<.<<<<.<<<.....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>>....>>>..>>>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..>>>......>>.>>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>..<....<<<<..<<<.<<<<<<<<.....>>.>>>>>>.>>>..>>>>...<.<........>.>.<<<<<<....<<<.<<<<<<<<<<..<<<...<<<....>>>...>>>...<<....>>..<<<<.....>>>>.....<<<<<<........>>>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<....<<<<<<<<.....<<<....<<<.<<<<....<.....>....>>>>.>>>..>>.>.....>>>>>>>>....>>>>>>>.>>..<<<<<<<<<<......>>>>>>.>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..<<<.........>>>..>>>......................>>>>>....>>>>>>>>>.>>...........)))......>>>>>>.>>>...>>>>>>><<<<<<<<<<....>>>>>>>>>>....>>>>>><.<<<<<<<<<.......<<<<<<<<....>>>>>>>>....>>>>>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<.<<.....<<<<....<<<<<<.<....<<<<.<<...<<<<<....<<<<.<<<......>>>.>>>>...>>>>>...>>.>>>>....>>>>>>>......>>>>.<<..<<<<<<...<<<<..<<<..<<<<..<<<<<...((((...>>>>>.<<..<<<....<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>....>>>...>>...<<<......>>>.....>>>>...>>>...>>>>........>>>>>>.>>..>>.>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<....<<..>>.....>>>>><<<<<<...<<.......<<.....>>.........>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.<<<....<<<<<.<<<<....>>>>..>>>>>....>>>.>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.((..<<<<<......))>>>>>>.<<<<<<<<.<<<.<<......<<<<<<<<<<..<<<<<..<<.<<<<<.<<<<<<<<<<<<<<<.............................<<..<.......>...>>...........................>>>>>>>>>>>>>>>...<<<.<<<<<<......>>>>>>>>>....>>>>>.>>...>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.<<..>>>>..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<.<<<<...<<.......>>...>>>>.>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>>>>>>>>>....<<<<<<<...<<<...<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))))>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>..>>>.......>>>>>>>..<<<<.....>>>>....<<<<.<<<<.......>>>>.....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>> (((.......((((((((((.....(((..(((((((((((((......((((((.[[.[[[.))).....((((((...(((]]]..]].)))......))))))...)))....(((....)))(((((((......))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((.((.......(([[[[[[))....)).))))))....(.((((.(((...(((((((.]]]]]].)))))))(((((.......((((((.((((.(((...(.((((......)))))[[(...).(((.....]])))...)))...)))))))))))))))....)))...))))]....(((((((...[.......)))))))....).(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((..(((.((((..((.....))...)))).)))..)))).<.(.(........).).((((((..(.(((.((((((((((..(((...(((....)))...)))....(....)...((((.....)))).....(((((..........))))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.((((........A.)))))))..).))))))))).(.(((.....)))...)..))))))......).))).(((((.....(((((....)))))(((((((((....((((((((.....(((....(((.((((....(.....)....)))).)))..)).).....))))))))....))))))).))..((((((((((......)))))).))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((((((......{...(((.(((...(...........)...))).....(..............).)))......))))))))).))...........]]].)....))))))))))...)))))))((((((((((....)))))))))).....)))))(.((((((((((......((((((((....))))))))...))))))))))..).....))))))(......((.....((((((.......))))))((((....((((..((...((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(.(((........))).)]](((((((((.((......(((....((.((..(....((((.((...((.((.(....((.(((.....).)).))...).)).))...)).))))....).)).))......)))..((...(((((...((((..(((..((((..(((((....{{{...))))).((..(((....(((((((((((.((.....))))))))).....))))..[.)))...))...(((......))).....))))...)))...))))(..)....)))))..))..)).)))))))))))))..)).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((....(........(....]).........)..))))))(...).......((((((((..].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((....((((..((((....))))...))))....))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))....).))))))).)..))).)))))))).)))))).....))[[..(((((.....>]])))))..((((((((.(((.((......(((((((.((..(((((..((.(((((.(((((.((....(................................(..............)..............................)....)).)))))...(((.((((((......)))))))))....))))).))...)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......)).)..))))))......(((((.(.(.((((...((.......))...)))).)...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..a.))..)))))))))))[..<(((((((...(((...(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....)))..)))..]....)))))))..((((....>))))....((((.((((.......)))).....((((((((.(((....(((((....)))))...)))..))))).)))...)))).....))) CryoEM structure of A2296-methylated Mycobacterium tuberculosis ribosome bound with SEQ-9; 23S rRNA 7kgb B 115 2.7 RF00001 URS00005330B1_83332 36827973 0003735 0005840 83332 uuacggcggccacagcggcagggaaacgcccggucccauuccgaacccggaagcuaagccugccagcgccgaugauacugccccuccggguggaaaaguaggacaccgccgaaca .<.<<<<<<.....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<.......<<<<<<....>>>>>>.......>>...>>>>>>.>.. .(.((((((.....((((((((.....((((((...(.....)...))))..))....)))))).)).((.......((((((....)))))).......))...)))))).).. CryoEM structure of A2296-methylated Mycobacterium tuberculosis ribosome bound with SEQ-9; 5S rRNA 7kgb a 1519 2.7 RF00177,RF01959,RF01960 URS00002C0A67_83332 36827973 0003735 0005840 83332 uggagaguuugauccuggcucaggacgaacgcuggcggcgugcuuaacacaugcaagucgaacggaaaggucucuucggagauacucgaguggcgaacgggugaguaacacgugggugaucugcccugcacuucgggauaagccugggaaacugggucuaauaccggauaggaccacgggaugcaugucuugugguggaaagcgcuuuagcggugugggaugagcccgcggccuaucagcuuguugguggggugacggccuaccaaggcgacgacggguagccggccugagaggguguccggccacacugggacugagauacggcccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagcgacgccgcgugggggaugacggccuucggguuguaaaccucuuucaccaucgacgaagguccggguucucucggauugacgguagguggagaagaagcaccggccaacuacgugccagcagccncgguaauacguagggugcgagcguuguccggaauuacugggcguaaagagcucguaggugguuugucgcguuguucgugaaaucucacggcuuaacugugagcgugcgggcgauacgggcagacuagaguacugcaggggagacuggaauuccugguguagcgguggaaugcgcagauaucaggaggaacaccgguggcgaaggcgggucucugggcaguaacugacgcugaggagcgaaagcguggggagcgaacaggauuagauacccugguaguccacgccguaaacgguggguacuagguguggguuuccuuccuugggauccgugccguagcuaacgcauuaaguaccccgccuggggaguacggccgcaaggcuaaaacucaaaggaauugacgggggcccgcacaagcggcggagcauguggauuaauucgaunnaacgcgaagaaccuuaccuggguuugacaugcacaggacgcgucuagagauaggcguucccuuguggccugugugcagguggugcauggcugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuugucucauguugccagcacguaaugguggggacucgugagagacugccggggucaacucggaggaagguggggaugacgucaagucaucaugccccuuauguccagggcuucacacaugcuacaauggccgguacaaagggcugcgaugccgcgagguuaagcgaauccuuaaaagccggucucaguucggaucggggucugcaacucgaccccgugaagucggagucgcuaguaaucgcagaucagcaacgcugcggugaauacguucccgggccuuguacacaccgnccgucacgucaugaaagucgguaacacccgaagccaguggccuaacccucgggagggagcugucgaaggugggaucggcgauugggacgaagucgnaacaagguagccguaccngnnggugcggcuggauc ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<..<<..<<<....>>>...>>>..>>>>>......<<........<<<<<<<..<<...<<<<<<<<<<<<.....<<<<<......>>>>>......>>>>.....<<<<<<<<<<....>>>>>>>>>>.....<<......>>>>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<<<<<<.......>.>>>>>.......>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<.....<<<<<<<.....>>>>>>>...>>>>>>>..>>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<<..<<<......>>>.....>>>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<.<........>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<.......<<<<....<<<.<.<....>.>.>>>..<......>....>>>>..<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<<..<<........>>>>.....>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<..<<<<....<.<<<<..<<<..<<<..>>>.>>>.>>>>.>...>>>>..>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(....(....).....)))..)))))......(((.......(((((((..((...(((.((((((((.....((((((....))))))......))))......(((((((((....)))))))))......((......)))))).)))..))))))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(..((.((((.....).))).))..)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((.....(((((((.....)))))))...))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((.((......))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((..(..(((.(.(....).).)))...........)...))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..((........))))....)))))))..(..(((.(.....).))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((..........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((..((((....(.((((..(((..((....)).))).)))).)...))))..))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... CryoEM structure of A2296-methylated Mycobacterium tuberculosis ribosome bound with SEQ-9; 16S rRNA 7kgb y 77 2.7 RF00005 URS000041AF00_83332 36827973 0030533 0006412 83332 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(.(((..]....))).)))))))..... CryoEM structure of A2296-methylated Mycobacterium tuberculosis ribosome bound with SEQ-9; tRNA-initiator Met(CAU) 7ki3 B 19 3.0 URS00001B8558_9606 34824224 0042593,0042632,0045723,0046322,0070328,0106120 9606 uggagugugacaauggugu ................... ................... Human Argonaute2:miR-122 bound to the HCV genotype 1a site-1 RNA; miR-122 7ki3 C 29 3.0 URS000231198F_3052230 34824224 3052230 gccagccgccugauggcggcgacacucca ....<<<<<<....>>>>>>......... ....((((((....))))))......... Human Argonaute2:miR-122 bound to the HCV genotype 1a site-1 RNA; HCV genotype 1a miR-122 site-1 7ki3 E 11 3.0 URS00001B8558_9606 34824224 0042593,0042632,0045723,0046322,0070328,0106120 9606 uggaguguggu ........... ........... Human Argonaute2:miR-122 bound to the HCV genotype 1a site-1 RNA; miR-122 7ki3 F 21 3.0 URS000231198F_3052230 34824224 3052230 gccgccggcggcgacacucca <<<<<..>>>>>......... (((((..)))))......... Human Argonaute2:miR-122 bound to the HCV genotype 1a site-1 RNA; HCV genotype 1a miR-122 site-1 7kjv C 22 2.8 URS00021ED987_11676 33947853 11676 uggcgcccgaacagggacuuga ...................... ...................... Structure of HIV-1 reverse transcriptase initiation complex core; HIV-1 viral RNA fragment 7kjv D 22 2.8 URS00021ED98D_9606 33947853 9606 ucaagucccuguucggncgcca ...................... ...................... Structure of HIV-1 reverse transcriptase initiation complex core; tRNA lysine 3 fragment with GNRA tetraloop 7kjw C 22 2.9 URS00021ED987_11676 33947853 11676 uggcgcccgaacagggacuuga ...................... ...................... Structure of HIV-1 reverse transcriptase initiation complex core with efavirenz; HIV-1 viral RNA fragment 7kjw D 22 2.9 URS00021ED98D_9606 33947853 9606 ucaagucccuguucggncgcca ...................... ...................... Structure of HIV-1 reverse transcriptase initiation complex core with efavirenz; tRNA lysine 3 fragment with GNRA tetraloop 7kjx C 22 3.1 URS00021ED987_11676 33947853 11676 uggcgcccgaacagggacuuga ...................... ...................... Structure of HIV-1 reverse transcriptase initiation complex core with nevirapine; HIV-1 viral RNA fragment 7kjx D 22 3.1 URS0000D54ECB_9606 33947853 9606 ucaagucccuguucggncgcca ...................... ...................... Structure of HIV-1 reverse transcriptase initiation complex core with nevirapine; tRNA lysine 3 fragment with GNRA tetraloop 7krn P 37 3.4 URS00021ED915_2697049 33883267 2697049 cguagcaugcuacgucauucuccuaagaagcuacccc ..................................... ..................................... Structure of SARS-CoV-2 backtracked complex bound to nsp13 helicase - nsp13(1)-BTC; RNA (37-MER) 7krn T 43 3.4 URS00021ED933_2697049 33883267 2697049 cccauguuaauagcuucuuaggagaaugacguagcaugcuacg ........................................... ........................................... Structure of SARS-CoV-2 backtracked complex bound to nsp13 helicase - nsp13(1)-BTC; RNA (43-MER) 7kro P 37 3.6 URS00021ED915_2697049 33883267 2697049 cguagcaugcuacgucauucuccuaagaagcuacccc ..................................... ..................................... Structure of SARS-CoV-2 backtracked complex complex bound to nsp13 helicase - nsp13(2)-BTC; RNA (37-MER) 7kro T 43 3.6 URS00021ED933_2697049 33883267 2697049 cccauguuaauagcuucuuaggagaaugacguagcaugcuacg ........................................... ........................................... Structure of SARS-CoV-2 backtracked complex complex bound to nsp13 helicase - nsp13(2)-BTC; RNA (43-MER) 7krp P 37 3.2 URS00021ED915_2697049 33883267 2697049 cguagcaugcuacgucauucuccuaagaagcuacccc ..................................... ..................................... Structure of SARS-CoV-2 backtracked complex complex bound to nsp13 helicase - BTC (local refinement); RNA (37-MER) 7krp T 36 3.2 URS00021ED933_2697049 33883267 2697049 uaauagcuucuuaggagaaugacguagcaugcuacg .................................... .................................... Structure of SARS-CoV-2 backtracked complex complex bound to nsp13 helicase - BTC (local refinement); RNA (36-MER) 7kuk A 14 1.67 34428345 32630 nnnnacuuaagucg .............. .............. High resolution RNA primer complex with guanosine dinucleotide ligand G(5')ppp(5')G; RNA (5'-R(*(LKC)P*(LCC)P*(LCC)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*G)-3') 7kuk B 14 1.67 34428345 32630 nnnnacuuaagucg .............. .............. High resolution RNA primer complex with guanosine dinucleotide ligand G(5')ppp(5')G; RNA (5'-R(*(LKC)P*(LCC)P*(LCC)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*G)-3') 7kul A 14 1.64 34428345 32630 nnnnacuuaagucg .............. .............. DNA modification at 3' end of RNA primer complex with guanosine dinucleotide ligand G(5')ppp(5')G; DNA/RNA (5'-R(*(LKC)P*(LCC)P*(LCC)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*C)-D(P*G)-3') 7kul B 14 1.64 34428345 32630 nnnnacuuaagucg .............. .............. DNA modification at 3' end of RNA primer complex with guanosine dinucleotide ligand G(5')ppp(5')G; DNA/RNA (5'-R(*(LKC)P*(LCC)P*(LCC)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*C)-D(P*G)-3') 7kum A 14 1.714 34428345 32630 nnnnacuuaagucn .............. .............. LNA modification at 3' end of RNA primer complex with guanosine dinucleotide ligand G(5')ppp(5')G; 5'-R((LCC)P*(LCC)P*(LCC)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*(LCG)-3' 7kum B 14 1.714 34428345 32630 nnnnacuuaagucn .............. .............. LNA modification at 3' end of RNA primer complex with guanosine dinucleotide ligand G(5')ppp(5')G; 5'-R((LCC)P*(LCC)P*(LCC)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*(LCG)-3' 7kun A 14 1.58 34428345 32630 nnnnacuuaagucn .............. .............. 2'-F modification at 3' end of RNA primer complex with guanosine dinucleotide ligand G(5')ppp(5')G; RNA (5'-R(*(LKC)P*(LCC)P*(LCC)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*C)-D(P*(GF2))-3') 7kun B 14 1.58 34428345 32630 nnnnacuuaagucn .............. .............. 2'-F modification at 3' end of RNA primer complex with guanosine dinucleotide ligand G(5')ppp(5')G; RNA (5'-R(*(LKC)P*(LCC)P*(LCC)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*C)-D(P*(GF2))-3') 7kuo A 14 2.281 34428345 32630 nnnnacuuaagucn .............. .............. FANA modification at 3' end of RNA primer complex with guanosine dinucleotide ligand G(5')ppp(5')G; RNA (5'-R((LCC)P*(LCC)P*(LCC)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*(GFL))-3') 7kuo B 14 2.281 34428345 32630 nnnnacuuaagucn .............. .............. FANA modification at 3' end of RNA primer complex with guanosine dinucleotide ligand G(5')ppp(5')G; RNA (5'-R((LCC)P*(LCC)P*(LCC)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*(GFL))-3') 7kup A 14 1.44 34428345 32630 nnnnacuuaagucn .............. .............. 2'-OMe modification at 3' end of RNA primer complex with guanosine dinucleotide ligand G(5')ppp(5')G; 5'-R((LCC)P*(LCC)P*(LCC)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*(OMG))-3' 7kup B 14 1.44 34428345 32630 nnnnacuuaagucn .............. .............. 2'-OMe modification at 3' end of RNA primer complex with guanosine dinucleotide ligand G(5')ppp(5')G; 5'-R((LCC)P*(LCC)P*(LCC)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*(OMG))-3' 7kwg A 32 3.75 34869582 93061 acauacaggggguauuaauuugaaaaagaaaa ................................ ................................ Staphylococcus aureus 30S ribosomal subunit in presence of spermidine; mRNA 7kwg a 1552 3.75 RF00177,RF01959,RF01960 URS00021ED94C_93061 34869582 0003735 0005840 93061 cuggagaguuugauccuggcucaggaugaacgcuggcggcgugccuaauacaugcaagucgagcgaacggacgagaagcuugcuucucugauguuagcggcggacgggugaguaacacguggauaaccuaccuauaagacugggauaacuucgggaaaccguagcuaauaccggauaauauuuugaaccgcaugguucaaaagugaaagacggucuugcugucacuuauagauggauccgcgcugcauuagcuaguugguaagguaacggcuuaccaaggcaacgaugcauagccgaccugagagggugaucggccacacuggaacugagacacgguccagacuccuacgggaggcagcaguagggaaucuuccgcaaugggcgaaagccugacggagcaacgccgcgugagugaugaaggucuucggaucguaaaacucuguuauuagggaagaacauauguguaaguaacugugcacaucuugacgguaccuaaucagaaagccacggcuaacuacgugccagcagccgcgguaauacguagguggcaagcguuauccggaauuauugggcguaaagcgcgcguaggcgguuuuuuaagucugaugugaaagcccacggcucaaccguggagggucauuggaaacuggaaaacuugagugcagaagaggaaaguggaauuccauguguagcggugaaaugcgcagagauauggaggaacaccaguggcgaaggcgacuuucuggucuguaacugacgcugaugugcgaaagcguggggaucaaacaggauuagauacccugguaguccacgccguaaacgaugagugcuaaguguuaggggguuucccgccccuuagugcugcagcuaacgcauuaagcacuccgccuggggaguacgaccgcaagguugaaacucaaaggaauugacggggacccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaaaucuugacauccuuugacaacucuagagauagagccuuccccuucgggggacaaagugacagguggugcaugguugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuuaagcuuaguugccaucauuaaguugggcacucuaaguugacugccggugacaaaccggaggaagguggggaugacgucaaaucaucaugccccuuaugauuugggcuacacacgugcuacaauggacaauacaaagggcagcgaaaccgcgaggucaagcaaaucccauaaaguuguucucaguucggauuguagucugcaacucgacuacaugaagcuggaaucgcuaguaaucguagaucagcaugcuacggugaauacguucccgggucuuguacacaccgcccgucacaccacgagaguuuguaacacccgaagccgguggaguaaccuuuuaggagcuagccgucgaaggugggacaaaugauuggggugaagucguaacaagguagccguaucggaaggugcggcuggaucaccuccuuucu .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<<<......................>>>>.>>>>>......<<........<<<<<<<..<<...<<<<<<<.<<<<.....<<.<<......>>.>>......>>>>.....<<<<<<<<<<....>>>>>>>>>.>....<<<<<<...>>>>>>.>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<<<<<<<........<<.<<................>>.>.>......>>>>>>...>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<<..<<<.<<<<<<<.<<<<<<<<<.......<<<<<<.....>>>>>>.....>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>..>>>>>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<<.....>>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<...<<.<<<<<<.<<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<......<<<<<....>>>>>.....<<<....>>>...>.>>.>>..<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<..<<<<<<..<<<..<<......>>>>>...>>>>>>......<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>....>>>>>>>...>>.>>>>>>>>.>...<<<<<<<.....<<<..<<...<<......>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>.....>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<..<<<<....<.<<<<..<<<..<<<...>>>.>>>.>>>>.>...>>>>..>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>................ .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((..((........................))..)))))......(((.......(((((((..((...(((((((.((((.....((.((.(...))).))......)))).....((((((((((....))))))))).)....(((.((...)).))).)))))))..))))))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....((((((.........(.(....(.......)......))........))))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))...).)))))))..)))))))))..(((.(((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))))..))..))))...))))....((((((....(...((((.........))))...).))))))......{...((((((..(((((((((.((.......).))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.((((........(((((..((((((((((......((........))...........((((((..(...((.((......(((((....)))))....(.(......))...).)..))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....(((...(..(((..(((..((......)))))...)))...)..(..(((((.....))))).....)...))).....).).)))...)).)))))....))))))....)).)))))))).(...(((((((.....(((..((...(.(.....))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))..............))))))).))..(.(..((.(.((((.(((..((((((..((((....(.((((..(((..(((...))).))).)))).)...))))..))))))..))).))))..).))...)..)..(((((((((....)))))))))}............... Staphylococcus aureus 30S ribosomal subunit in presence of spermidine; 16S ribosomal RNA 7kx9 B 24 3.5 URS0002311A06_32630 34471284 32630 ucucuugaguuggacaaauggcan ........................ ........................ Cryo-EM structure of Ephydatia fluviatilis PiwiA-piRNA-target complex; RNA (5'-R(P*UP*CP*UP*CP*UP*UP*GP*AP*GP*UP*UP*GP*GP*AP*CP*AP*AP*AP*UP*GP*GP*CP*AP*(OMG))-3') 7kx9 C 16 3.5 URS0002311971_32630 34471284 32630 uguccaacucaagaga ................ ................ Cryo-EM structure of Ephydatia fluviatilis PiwiA-piRNA-target complex; RNA (5'-R(P*UP*GP*UP*CP*CP*AP*AP*CP*UP*CP*AP*AP*GP*AP*GP*A)-3') 7l08 AA 944 3.49 RF00177 URS000044DFF6_9606 34127662 0003735 0005840 9606 auagguuugguccuagccuuucuauuagcucuuaguaagauuacacaugcaagcauccccguuccagugaguucacccucuaaaucaccacgaucaaaaggaacaagcaucaagcacgcagcaaugcagcucaaaacgcuuagccuagccacacccccacgggaaacagcagugauuaaccuuuagcaauaaacgaaaguuuaacuaagcuauacuaaccccaggguuggucaauuucgugccagccaccgcggucacacgauuaacccaagucaauagaagccggcguaaagaguguuuuagaucacccccaauaaagcuaaaacucaccugaguuguaaaaaacuccaguugacacaaaauagacuacgaaaguggcuuuaacauaucugaacacacaauagcuaagacccaaacugggauuagauaccccacuaugcuuagcccuaaaccucaacaguuaaaucaacaaaacugcucgccagaacacuacgagccacagcuuaaaacucaaaggaccuggcggugcuucauaucccucuagaggagccuguucuguaaucgauaaaccccgaucaaccucaccaccucuugcucagccuauauaccgccaucuucagcaaacccugaugaaggcuacaaaguaagcgcaaguacccacguaaagacguuaggucaagguguagcccaugagguggcaagaaaugggcuacauuuucuaccccagaaacgauagcccuuaugaaacuuaagggucgaagguggauuuagcaguaaacuaagaguagagugcuuaguugaacagggcccugaagcgcguacacaccgcccgucacccuccucaaguauacuucaaaggacauuuaacuaaaaccccuacgcauuuauauagaggagacaagucguaacaugguaaguguacuggaaagugcacuuggacgaac ..((((..<<<<<<.)))).<<<<<<.<<..<<<<<<<<..<.<<<.<<<..<......>......<<........<<<....<<<.....>>>....>>>...<<<<....<<...<<<....>>>..>>......>>>>.<<...>>.>>.<<<....>>>.....>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>.....<<<<<<<<.....(((.....((.>>>)).......)))..>>>>>..>>.>>>>>>....<<<((.....<<<<..<<<<..........<<<<<<......<<<.<<<.<<<......>>>..>>>.>>>.............<<....>>.>>>>>>.....>>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<.<<<<<......))..>>>>>.>.>>>.<<.......<<<<....>>>>.....>>..>>>>>><<<<<.<<<<<<<...<<<.<<<<<.<<<<<<<<<<<.....<<........>>..........<<<<<<<.......<<.<<<..<<<<<<.......<<..<<<<<.....>>>.......>>..>>.....<<<....>>>.........>>>...>>>>>>>>....>>>>>>>..>>.>>>>>>>>.>...<<<<.....>>>>.<....<<<<<<<.......>>>>>>>....>.....>>>>>.....<<<<<<<.........>>>>>>>.....>>>...>>>>>>>>>>.>>....<..<<.<...<<<<<<..<<<<<..<....<.....<<.....>>.....>....>..>>>>>.>>>>>>....>.>>...>.....<<<<<<<<<....>>>>>>>>>........ [.[[[[..(((((..]]]]]((((((.((..((((((((..(.(((.(((..(......)......(((.......(((.(..(((.....))).)..)))...((((....((..((((....))).)))......)))).((...))))).(((....))).....)))))))......(.(((...(((((....)))).))))).)).)))))).....((((([[[.....(((.....((.]]])).......)))..)))))..)).))))))....((([[...(.((((...(((..........(((((((.....(((.(((.((........))..))).))).....).....(.((....))))))))).....)))....))))....((((((...((...((((.........))))...))))))))......{...(.(((((......]]..))))).))))).((.......((((....)))).....))...)))))(((((.(((((((...(((.(((((..((((((((((.....((........))..........(((((((.......((.(((...((((((.(....((..(((((.....))).......))..)).....(((....))).....).).)))...)).)))))....)))))))..)).)))))))).(...((((.....)))).(....(((((((.......)))))).)....).)..))))).....(((((((.........))))))).....)))...)))))))))).))..(.(..((.(...((((((..(((((..((..(.(....((.....))...).)..).)..))))).))))))....).))...)..)..(((((((((....)))))))))}....... Cryo-EM structure of the human 55S mitoribosome-RRFmt complex.; 12S rRNA 7l08 A 1527 3.49 RF02541,RF02540 URS000080E357_9606 34127662 0003735 0005840 9606 gcuaaaccuagccccaaacccacuccaccuuacuaccagacaaccuuagccaaaccauuuacccaaauaaaguauaggcgauagaaauugaaaccuggcgcaauagauauaguaccgcaagggaaagaugaaaaauuauaaccaagcauaauauagcaaggacuaaccccuauaccuucugcauaaugaauuaacuagaaauaacuuugcaaggagagccaaagcuaagacccccgaaaccagacgagcuaccuaagaacagcuaaaagagcacacccgucuauguagcaaaauagugggaagauuuauagguagaggcgacaaaccuaccgagccuggugauagcugguuguccaagauagaaucuuaguucaacuuuaaauuugcccacagaacccucuaaauccccuuguaaauuuaacuguuaguccaaagaggaacagcucuuuggacacuaggaaaaaaccuuguagagagaguaaaaaauuuaacacccauaguaggccuaaaagcagccaccaauuaagaaagcguucaagcucaacacccacuaccuaaaaaaucccaaacauauaacugaacuccucacacccaauuggaccaaucuaucacccuauagaagaacuaauguuaguauaaguaacaugaaaacauucuccuccgcauaagccugcgucagauuaaaacacugaacugacaauuaacagcccaauaucuacaaucaaccaacaagucauuauuacccucacugucaacccaacacaggcaugcucauaaggaaagguuaaaaaaaguaaaaggaacucggcaaaucuuaccccgccuguuuaccaaaaacaucaccucuagcaucaccaguauuagaggcaccgccugcccagugacacauguuuaacggccgcgguacccuaaccgugcaaagguagcauaaucacuuguuccuuaaauagggaccuguaugaauggcuccacgaggguucagcugucucuuacuuuuaaccagugaaauugaccugcccgugaagaggcgggcauaacacagcaagacgagaagacccuauggagcuuuaauuuauuaaugcaaacaguauaccaaaccugcauuaaaaauuucgguuggggcgaccucggagcagaacccaaccuccgagcaguacaugcuaagacuucaccagucaaagcgaaccucaauugauccaauaacuugaccaacggaacaaguuacccuagggauaacagcgcaauccuauucuagaguccauaucaacaauaggguuuacgaccucgauguuggaucaggacaucccgauggugcagccgcuauuaaagguucguuuguucaacgauuaaaguccuacgugaucugaguucagaccggaguaauccaggucgguuucuaucuacuuucaaauuccucccuguacgaaaggacaagagaaauaaggccuacuucacaaagcgccuucccccguaaaugauaucaucucaacuuaguauuauacccacacccacccaagaacaggguuu <<<.......<<<<.....................................<......>.........<.....<<.....>>....>........>>.>>.............<<....>>......................>>>...........<<<.......>>>...<.<........>.>.<<<<<<.........<<<.<<..<<....>>...>>.>>>...<<.<..<<<<<.<.....<<<<<.<<<..<<<.....>>>...<<<..<<<<........>>>>.>>>....>>>.>>>>>...<<.......>>......>.>>>>...>..>.>>..<<<<<<....<<<<....>>>><<<.<<<<<<<<<<.....<<..........>>.....>>>>>>>>>>..>>>.<<<<<<<<<<......>>>>>>>>>>.<.<<<......>>>.>..<<<.<<<...<..............<.....<<.........>>.....>.......<<<......>>>....................................>...>>>>>>........>>>>>>...<<<<<......>>>>>.........>>>>>><......<<..<<<....>>><<<<..<<<<........<<<<<..............>>>>>......<<<...<<<<.......................>>>>.......>>>.....<<......>>.>>>>.....>>>>..<<<<...<<<<<<<<.<<................<<<<<<..<<<.........>>>...<<<<<<.............>>>>>>....<<<.<<<..<<<<<....>>>..>>>>><<<<<<......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>....>>.>>>>........>>.>>>>>>>>>>>>.>>.....>.....<<<<<........>>>>>.......<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<................>>>>>>>>>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<.....<<<..<<<<.....>>>>..>>>....>>.........<<<....>>>............>>>>..>>>>>>.......<<<..<.<<<<<<...<<.......>>...>>>>>>...>.>>.>.......<.<<<.<<<<<<..<<.<<<<<<......>>>>>>...>>.<<<<<.....>>>>>.....>>>>>..>...>>>..>....<<<<<<<....>>>.>>>>....>>..>>>.>>...<.<<<.<<<.................>>>.>>><<<<<...<<<....>>>.>>>>>......<<<................>>>......>..........<<<<.......>>>>.. ((.....(..((((.....................................(...[..).........(.....((.]...))....)........)).)).............((....))....)..................)).........(.(((.......))).[.(.(........).).((((((.........(((.((..((....))...)).)))...((.(...((((.(.....(((((.((((.(((....[)))...(((..((((.......{)))).)))..).))).))))).(.((.......))...)..).))))......).))..((((((....((((....)))).((.((((((((((.....((..........)).....))))))))))..))..((((((((((......))))))))))...(((......)))....(((.(((...(..............(.(...((.........).)..).)....(..(((......))))...................................)...))))))........))))))...(((((......))))).........))))))(......((..(((....)))(((...((((......(.(((((.....(....)...)))))......(((...((((...............(..)....)))).......))).)...((......)).))))......)))..((((....(((((((.((..(.............((((((.].((.........))....((((((.............))))))....(((.(((..(((((....)))..)))))(((((........)))))........((..........(((((.......)))))..)..)....)))....)).)))).......))).))))))).)))).)).....)).{..(((((.....]}.))))).......((..(((.((......((((.((((((..(((((.((((((((....(.....).....)))))))))))))..(((......[)))((((((..........]))))))(.(......((...(((....[..)))...)).....).........(((....))).....)].....))))..))))))......((((..(.((((((.(.((.......)))..))))))...).)).).)......(.((.((((((..((.((((((......))))))...)).(((((.....))))).....)))))..)...))..).....(((((((....))).))))..}.))..))).))...(.(((.(((......(....).....))).)))(((((...(((....))).)))))......(((................)))......)..........((((.......)))).. Cryo-EM structure of the human 55S mitoribosome-RRFmt complex.; 16S RRNA 7l1f P 17 3.89 URS00021ED953_2697049 33631104 2697049 cuaagaagcuauunnnn ................. ................. SARS-CoV-2 RdRp in complex with 4 Remdesivir monophosphate; RNA (5'-R(P*CP*UP*AP*AP*GP*AP*AP*GP*CP*UP*AP*UP*U*(F86)*(F86)*(F86)*(F86))-3') 7l1f T 18 3.89 URS00021ED919_2697049 33631104 2697049 auuuuaauagcuucuuag .................. .................. SARS-CoV-2 RdRp in complex with 4 Remdesivir monophosphate; RNA (5'-R(P*AP*UP*UP*UP*UP*AP*AP*UP*AP*GP*CP*UP*UP*CP*UP*UP*AP*G)-3') 7lh5 AA 1504 3.27 RF00177,RF01959,RF01960 URS0002311A11_300852 34117352 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<...........>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<.<....<<<<<......>>>>>......>>>>....<<<<.<<<<<....>>>>>.>>>>...<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<.<.......>.>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<.....>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<..<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<........<...<<....>>...>......<......>.........>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<.........<.......>........>>>>>>......<..........>.........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<...<<<<....>>>>...>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>.....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((..((..(((..((.(((...................))).)))))......(((......((((((((..((...(((((((.((.(.....((............)).......))).....(((....((....))....)))....((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((.(....).))...)).))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(......................)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((.(((((((......(((.((.....)).)))....)))))))...)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((.((((.........)))).))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((...((((..((((...(((......((........))........(.(((((((..(...((.(.(..........................................).)))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((.(.(((.(.(..(.................)...).).)))...........................).)).....).).)))...)).)))))....)))))))).[)).)...)))).(...(((.(((.....(((...(..((((....))))..).....))).....))).)))......(....(((((((........)))))))....)..)..))))......(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Crystal structure of the Thermus thermophilus 70S ribosome in complex with plazomicin, mRNA and tRNAs; 16S ribosomal RNA 7lh5 AV 76 3.27 RF00005 URS00001BBAFC_562 34117352 0030533 0006412 562 gcgggguggagcagccugguagcucgucgggcucauaacccgaagaucgucgguucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((.........)))).(((((.......))))).....(((((.......)))))))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with plazomicin, mRNA and tRNAs; P-site tRNA fMet 7lh5 AW 76 3.27 RF00005 URS00005AA258_562 34117352 0030533 0006412 562 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca ...<<<...<<<<........>>>>..<<<<<.....>>>>>........<...........>...>>>....... ............................((.........)).........(...........)............. Crystal structure of the Thermus thermophilus 70S ribosome in complex with plazomicin, mRNA and tRNAs; E-Site tRNA Phe and A-site tRNA Phe 7lh5 AX 12 3.27 34117352 562 aaaaauguucua ............ ............ Crystal structure of the Thermus thermophilus 70S ribosome in complex with plazomicin, mRNA and tRNAs; mRNA 7lh5 AY 19 3.27 RF00005 URS00005AA258_562 34117352 0030533 0006412 562 aggggauugaaaauccccg ..<<<<<.....>>>>>.. .....(.......)..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with plazomicin, mRNA and tRNAs; E-Site tRNA Phe and A-site tRNA Phe 7lh5 BA 2824 3.27 RF02540,RF02541,RF00002 URS0002311A08_300852 34117352 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucgggggcccucggccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcgccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccuggcgccggugaaauccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu .........<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<....<<<))..)).>>>.......>>>>>...>>>....<<<....>>><<..<.........>...>>.<<<<<<..>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>.....<<<<<<.<........<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>.....>..>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<.<<<...>>>..>>>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<...<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...................>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<............<.........>.................................>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<...<<..[[[[...>>..>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>>.............>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<..........................>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>........<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>.....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...................<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....... .........((((((((((.....(((..((((((((((((......((((((.[[...[.))).....((((.....(((]...]].)))........))))...)))....(((....)))((..(.........)...)).((((......)))).))...(((.((.....(...[..)......)).)).).........((....))...(((((......(.]...).....)))))...((([...(((.((.........)).)))....(((((............(((((.(.((.(((...(((((......)))))[[(...).(((.....]])))...)))...)).)..)))))..........).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((.((((...))).).))))).[.(.(........).).((((((....(((((((((((....(((...(((.....)))...)))...((....))..((((.....))))....)))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((...................)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((..((........................................................................))..)))).))..........]]].)....))))))))))...)))))))(((.((.........)).)))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((......(((((.......))))).((((....((((..((..(((((((....(.....)..))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((.....(.((....(((((.(((..((((..(((..((...{{....))).))(((...((((((((((((.(((.((.....)))).)))).....)))))))))..)))..............))))...)))..)))))(..).....)).)........))))))))))))))).))).....((......)).)))).(..((....))..)..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((.........))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((..(.(.((((.(..........(......(...)...............).).)))).).)..))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((....((.}}.)).......)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))...................(((((((.(.......).)))....((((((((..((.....((((....))))....))...))))).)))...))))....... Crystal structure of the Thermus thermophilus 70S ribosome in complex with plazomicin, mRNA and tRNAs; 23S ribosomal RNA 7lh5 BB 120 3.27 RF00001 URS00005F2F4B_300852 34117352 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> .((((((((((....(((((.((....(((((((...(.....)...))))..)))...)).))).))(((.......((.(((((....))))).)).......))).)))))))))). Crystal structure of the Thermus thermophilus 70S ribosome in complex with plazomicin, mRNA and tRNAs; 5S ribosomal RNA 7lh5 CA 1504 3.27 RF00177,RF01959,RF01960 URS0002311A11_300852 34117352 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<..........>.>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<...<<<<<<......>>>>>.>...>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<.<....<<<<<<....>>>>>>.....<<<....>>>.....>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<.......>>>.....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(.((.(((........).)).)).).)))))......(((......((((((((..((...(((((.(..((((.....(((........)))......)))).....((((.(((((....))))).))))...((((...)))).).)))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))...(((......((((....)))).....))).....(((((...(....((.........)).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((.....)))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((.(....((.((......)).)).....(.(....).).....))))))).((.(((...((((((.(....((((((.((....))....(((......)))...)))))).....((((.(((((.(...(..............).....).))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((..((....(......)....))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Crystal structure of the Thermus thermophilus 70S ribosome in complex with plazomicin, mRNA and tRNAs; 16S ribosomal RNA 7lh5 CV 77 3.27 RF00005 URS00001BBAFC_562 34117352 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaagaucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with plazomicin, mRNA and tRNAs; P-site tRNA fMet 7lh5 CW 76 3.27 RF00005 URS00005AA258_562 34117352 0030533 0006412 562 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<...<<..........>>...<<<<.......>>>.>.......<.<........>>..>>>>>>>.... ((...((...(............).........................................))...)).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with plazomicin, mRNA and tRNAs; E-Site tRNA Phe and A-site tRNA Phe 7lh5 CX 12 3.27 34117352 562 aaaauguucuaa ............ ............ Crystal structure of the Thermus thermophilus 70S ribosome in complex with plazomicin, mRNA and tRNAs; mRNA 7lh5 CY 21 3.27 RF00005 URS00005AA258_562 34117352 0030533 0006412 562 gcaggggauugaaaauccccg ...<<<<<<.....>>>>>>. ....((((.......)))).. Crystal structure of the Thermus thermophilus 70S ribosome in complex with plazomicin, mRNA and tRNAs; E-Site tRNA Phe and A-site tRNA Phe 7lh5 DA 2824 3.27 RF02540,RF02541,RF00002 URS0002311A08_300852 34117352 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucgggggcccucggccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcgccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccuggcgccggugaaauccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu .........<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<..>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>.....<<<<<<<<...<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>..>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<....>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<...<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<.....<<....>>......>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<......................................................................>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>>.............>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<..<<...........<<<<.<...................>>>>>..>>..>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<<.....>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....... .........((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((..)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((((((.......)))))))....((((.((((...((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))..))))..)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((((((((....)))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))..)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((...................)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((.......................(........).......................................)))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.((...{{....))))))(((...((((((((((..((((.((.....))))))..).....)))))))))..)))(...........))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((.(...((.(.........(((((...(...)............)))))).))...).)))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))...(.........).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....... Crystal structure of the Thermus thermophilus 70S ribosome in complex with plazomicin, mRNA and tRNAs; 23S ribosomal RNA 7lh5 DB 119 3.27 RF00001 URS00005F2F4B_300852 34117352 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggg .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>> ..(((((((((....(((((.((....(((((((...(.....)...))))..)))...)).))).))(((.......((.(((((....))))).)).......))).))))))))). Crystal structure of the Thermus thermophilus 70S ribosome in complex with plazomicin, mRNA and tRNAs; 5S ribosomal RNA 7ljy B 76 5.6 URS00021ED969_4530 33785601 4530 ggguacucuuuucuuugucaugguuuucucaggcgaaagucugaguuuuuacaugacaaaguuuuuaacgaggccc <<<<.<<<....<<<<<<<<<<.<...<<<<<<<....>>>>>>>.....>>>>>>>>>>>........>>>>>>> ((((.(((.....(((((((((.....(((((.(....).)))))......))))))))).........))))))) Cryo-EM structure of the B dENE construct complexed with a 28-mer poly(A); B dENE construct 7ljy A 25 5.6 URS00021ED909_32630 33785601 32630 aaaaaaaaaaaaaaaaaaaaaaaaa ......................... ......................... Cryo-EM structure of the B dENE construct complexed with a 28-mer poly(A); poly(A) 7lo9 A 12 1.78 URS000080E0B7_32630 34648028 32630 cgcgnanuagcg ............ ............ RNA dodecamer containing a GNA A residue; Chains: A,B,C,D 7lo9 B 12 1.78 URS000080E0B7_32630 34648028 32630 cgcgnanuagcg ............ ............ RNA dodecamer containing a GNA A residue; Chains: A,B,C,D 7lo9 C 12 1.78 URS000080E0B7_32630 34648028 32630 cgcgnanuagcg ............ ............ RNA dodecamer containing a GNA A residue; Chains: A,B,C,D 7lo9 D 12 1.78 URS000080E0B7_32630 34648028 32630 cgcgnanuagcg ............ ............ RNA dodecamer containing a GNA A residue; Chains: A,B,C,D 7ls1 A2 3707 3.3 RF02543,RF02540 URS0002311A05_10090 34815424 0003735 0005840 10090 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccgcgcgucgcggcgugggaaauguggcguacggaagacccacuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugagnccgguagcggcccccggcgcgccgggcucgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaanggaaaguugaaaagaacuuugaagngagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcgcguccggccgugccggugguccggcggaucuuucccgcgcgggggaccgcccccggccggcgaccggccgccgccgggcgcacuuccaccguggcggugcgccgcgaccggcuccgggacggccgggaaggcccgguggggaagguggcucggggggggcucaccccgaguguuacagcccuccggccgcgcuuuucgccgaaucccggggccgaggaagcccgucgccgcncucucccucucccgggugggggccgggccgccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgucgucgcgccgucgggucccgggggcgucggucacgcgugacgaagccgagcgcacggggucggcggcgaugucggcuacccacccgacccgucuugaaacncggaccaaggagucuaacgcgugcgcgagucaggggcucguccgaaagccgccguggcgcaaugaaggugaagggccccgcccgggggcccgaggugggaucccgaggccucuccaguccgccgagggngcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcguacgcguuagnacccnanagauggugancuaugcuugggcagggcgaagccagaggaaacucuggugnagguccguagcgguccugacgugcaaaucgnucguccgaccuggguauagnggcgaaagacuaaucgaaccaucuaguagcuggnucccuccgaaguuucccucaggauagcuggcgcucucgcuacgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaaungguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuuggnaagcngaacuggcgcuncgggaugaaccgaacgccggguuaangcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggaugncgcuggagcgucgggcccauacccggccgucgccggcagucggaacggaacgggacgggagcggcgucgggccccgcggagccuacgccgcgacgaguaggagggccgcugcgnugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguagunnnaaauauucaaacgagaacuuugaaggccgaaguggngaaggguuccaugugaacagnanuugaacaugggucagucgguccugagagaugggcgagugccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucgnguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccucggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcnccgggccguaccnauauccgcagcaggucuncaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagcnggauccguaacuucgggauaaggauuggcucuaagggcugggucggucgcggccggcgccuagcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugccnagugcucugaaugucanagugnagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagcnaanugccucnucaucuaauuagugacgcgcaugaauggaugancgagauucccacugucccuaccuacuauccagcgaaaccacngncaagggaacgngcuuggnggaaucagcggggaaagaaganccuguugagcuugacucuagucuggcacggugaagagacaugagagguguagaauaagugggaggcccggccgccggugaaauaccacuacucucaucguuuuuucacugacccggugaggcgggggggcgagccccgaggggcucucgcuucuggcgccaagcguccgucccgcgcgugcgggcgggcgcgacccgcuccggggacagugccaggugggnaguuugacngnggcgguacaccugucaaacgguancgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucagnacgaauacagaccgugaaagcggggccunacgauccuucugaccuuuungguuuuaagcaggannugucagaaaaguuaccacagggauaacuggcuuguggcggccangcguucauagcgacgucgcuuuuugauccuungaugucggcucuuccuaucauugugaagcagaauunaccaagcguungauuguucacccacuaauagggaacgugagcuggguuuagancgucgugagacagnuuaguuuuacccuacugaugnuguguuguugccaugguaauccugcncaguacgagaggaaccgcagguncanacauuugguguaunugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgaggagccucgguuggccccggauagccggguccccguccugccccgcggccgggcgucgggaccgggguccgguncngagagccguucgucuugggaaacggggugcggccggaaagggggccgcccucucgcccgucacguugacgcacguucguguggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<<....<......>.....>>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..[[[..<.<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>.>..<<<<<<<<<....<<<<<<<<.<<<....<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>>>>>>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<......>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<..<......<<<<<<<<<....<<<.<<<.<<<<..<<....<<<<.<<<..<<<<<>>>>>>>>>>>>>>.>>>>>>>....>>>..>>>>>>>>>........>.>>>.>>>>>...<<<<<<<.<<<<<<<<<<.<<.....<<.<<<<.<<.<.<<......<<<<<<<<.<<..>>.>>>>>>>>........>>>>>>>>>.......>>..>>...>>>>>>>>>>...............<<<<<<.<<<<<.<<..>>.>>>>>...<<<..<<<<.<<<<<<<<<<<<<<<<<<<<<<<<<...........>.>>>>>>>>>>>..>>>>>>>>>>.>>>....>>>>..>>>.....<<.....>>.....>>>>>>......>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<.....>>>>>>>..<<<<<...<<<..<<<...(((.[[..>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<..<<........>>.>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<.......<<<.<<<<<<<<<.<...<....<<<....<<<<.....<<..........>>..>>>>....>>>..>.....>>>>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>>>>>>.>>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<............]].)))...<<<...>.>>..................>>>>>>>>>....>>>>>>.<.<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>..>.....>>>>>><<<....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<.<<<...>>>.>>>>>>>......>>....>>...<<<<<........>>>>>))<<<<....<<<<<...<<<<<<<....>>>>>>>...<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<..<<<<<<<<<..{{{..>>>>>>....<<<<<.<<<<.<<<......<<<.....>>>......>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>....>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<.<<<<<<<<<<<...<..........>........>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>....<<.<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>>.<<<<<.......>>>>>.........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>...>>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<<.<<<<<<<<<<<<..<<<...........<..............................>.>>>..>>.>>>>>>>>>>...<<<<<.....<.<<<....<<<<.<<...>>>>>>................<<<<<<<.<<<<<....>>>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<....<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>....<<<..<<<<.......>>>>..>>>.<<<....>>>.>>))).......((((((..(((..>>>>>>.)))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>..>>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]].....<<<<<<..<.<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<}}}.>>>>>..>>.>>...>>>>...>>>><<<<....<<<<<...........>>>>>....>>>>.>>>...>.>>>>>>.....<<<<<<.<<<..<<.<....<<<........<<<<<<.<<<<<..<<<.....<<<>>>.....>>.>..>>>>>>>>>>>.......>>>...<<<..<<.<....<<<<.<<<<<<........>>>>>>>>>>....>>>..>>>...............>.>>..>>>>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<....<<<<<......>>>>>...>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((...((((((((((.....)))))).)))).....)))....(((((((((....((((((((.((.....(((.(.((..(.((((......)))))....[[(...).(((.....]])))...).)..)))).))))))))))...)))))))))..)....(((((((........))))))).....(.(((..[[[[[[)).))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((....(((((.(..(.......(((((((((...(((..((.(((...((....((((.(((..((((())))))))))))))..))))).....))).))))))))).........)..)).))).)...((((((((((((((((((((.(.(..((.((((.((..(.(.......(((((((.(.().).))))))).........)).)))))).......))).))..)))))))))))...............((((((.(((.(.((())).).)))...(((..((((..((((((((((((.(((((((.(.(...........)..).)))))))...)))))))))).)).....))))..))).....((.....)).....)))))).....))).)))))...)))))...)))))))).[((((........))))((((((....(((((((((((((..(((..(((((........))))..)..)))...((....))...(((((((.....)))))))..(((((...(((..(((..[.[[....[)))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((.(((((.((((...(((((((....)))))))...)<)))...(((..((.((........)))).)))..).)))).)))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((.......(((.((((((((......(.....(...(.((((.(..(((..........)))))))).)...)....)......))))))...(.(((((((.(......))))))).))....))))))))))))..))..((((.((.((.....)).)).))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.....{.(((((.((....((.........))....)).......(.((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((..........]....]]..]..(.((.)))......(...)........)))))))))....)))))).(.(((((..(.((......((((.((((....))))))))...)))..)))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...(.....(((....)))..........((.((((.(.((...))..))))))).......)....))...(((((........)))))]]((((....(((((...(((((((....)))))))...(((....)))...(...((((((...(((.(.(((((((.((((.((((..{{{..)))).)....(((((.((((.(((......(((.....)))......)))))))..))))).....(((.((((....).))).))))).).).))))))..))))(...)....))))))...)..........)).))).)))).)))..)).....((......)).)))).((((.....))))..)))....(((......(((((((.((..(....(.......((((.....(.[..)......))))((.((((((((((.(..(.(.......))........)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).]..((.(((..((...(.....(......(((......)))......)...)....)))))(((((.........))).)).......((..........(((((.......)))))..)..).....))....)).))))))).)..))).)))))))...)))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((...(((((((.(((((.(.(((...(((............................................)))...).)).).)))))...(((((.....(.((((...((((.((..).))))).)..............(((.(((.(((((....)))))))).)))..))))..)))))....)))))))....)))))..(((......[)).)((((............]..))))(.((...(..((((.(.((((((.......))))))...).((...[[[))....))))...)(..((..((((....{..))))..)).)(((....))).))]]].......((.(((..(((..]]]]]].)))))).))....)}....))))..)))))).......(....(.((((((...((.......))...))))))...)....)........((((.(((((...(.(.((((........))).)..).)..((.........)).......))))..)...))).).....(((((((....))).))))....))..))).))))).....((((((..(.(((..(.((((.......(....)......)))).)((((....((((....(..(((((((}}}.)))))..))..)...))))...)))).(((....((((.....}.......))))....)))..)))...).)))))).....((((((.(((..((.(.(..(((........((((((.(((((..(.((....((()))...).)..)..))))))))))).......)))...(((..(.((....(..(.((((((........)))))))..)....)))..)))............)..).))..)))))))))(((((.(..(.......)..)....((.(((((((.((.....((((....(((((......)))))...))))....))....)))).))).))..))))).. 80S ribosome from mouse bound to eEF2 (Class II); 28S rRNA 7ls1 B2 120 3.3 RF00001 URS00000F9D45_10090 34815424 0003735 0005840 10090 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<.<<<............>>>...>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((.(((...(....)...)).)..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. 80S ribosome from mouse bound to eEF2 (Class II); 5S rRNA 7ls1 C2 156 3.3 RF00002 URS00023119E6_10090 34815424 0003735 0005840 10090 cgacucuuagcggnggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<<<<....>>>>.....<.<<<......>>.............>>>..>...>>>....<<....>><<<<<<<<<.....>>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))((((((((.......)))))))).................... 80S ribosome from mouse bound to eEF2 (Class II); 5.8S rRNA 7ls1 m2 1723 3.3 RF01960,RF01959,RF00177 URS00023119FF_10090 34815424 0003735 0005840 10090 uaccugguugauccugccaguagcaunugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuauggunccuuuggucgcucguacuuggauaacugugguaauucuagngcuaauacaugccgacgggcgcugaccccccuucccggggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgccccccguggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugangaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauancguauauuaaaguugcugcaguunaaaagcucguaguungaucuugggagcgggcguccccgcccucucggcggggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagancgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacncaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccugcgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggugcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucgnaacaagguuucnguaggugaaccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<......<<..<......<<<.<<<........<<....<<..........>>...>>.........<<........<<<.<..........<<<...........<<.....<<.............>>......>>.........<<<<<..<<<<<<<....>>>>>>>.>.>>>><<..<<<<<...<......>..>>>>>......>>....<<<.<<<<......>>>>>>>.....>>>.......>.>>>.<<<....<<<.......<<<<.........>>>.>..>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<<..>>>.>...>>>>>>.........<<<....<<<.....>>>..>>>..>...>>.......<<<<<<<<<.<<<....>>>..>>>>>.>>>>......<<..<...........>..>>.........<<<<<.((...<.<<<<.....<<..))>>.......>>>>>>>>>>...>>>>>.>>>.........<.<((.....<.<<...<<<..........................<<.<............>>>....<<<<<.<.......<<...<.......>..<<..........>>...>>......>.>>>..>>.........<.<..<<<<<<<...............>>>>>>>..>.>..........<<<<<.<.<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<........>>>>>>>>>.>..>>>....<<.))>>...>>.....>>>.>.>.<<.......<<<<....>>>>.....>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<......>>...<<<......>>>...>>.>>>....<<<...<...<<<...<<<<<<<<<<<<.......>>>>.>>>>.....>>>>...>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<<<<<<....>>>>>>>>....>.........>>>.>>............<<<<<..........>>>>>...........>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<...<<<.<<...<<<<<.<<<<<<<<<..>>>>>>>>>...>>>>>...>>.>>>...>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..)))).(..(((((.......(..(......(((.(((..(...........((.(......).)).....[.).......((.......(((.(...(.(....(((...........((......(.............).......)).........(((((..((((((......)))))).).))))((..(((((...((...).)..)))))......)).....((.((((......))))))......)))....).)).))).(((....((........((((.........))).)...))......)))...(((.(((......)))....)))))..(..(((..........)))..).(.(.(...)).)...)))))).......(.(((...((((.]...))).))))).)...)........(((.(((((.(((....)))..)))))..)))....(.(...(...........)...)......)..(((((.[....(.((((.....((...])).......))))))))))...)))))..)...[......(.([[...(.(.((.....(..(........(............)....(............)......(.(.(.(.......((..(.........)..(..(.....).)....))......).).)...).........(..(.((((((.(............)..))))))..).).....)....(...(...(...((((..(((.((((((((...((........))......)))))))).))).......((....))...))))..)...)....)...).....)).)....(((((.....(...((((.........))))...)..)))))......{....((.((..((..(.((((((.((..........)))))))).)..)).....((.]]))...))...].)).)).).(.(......((((....)))).....))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((........((.(((........))).))......)))))....(.(((...(.((((((....(((.((.((....))...(.((......)))...)).)))....(((...(...((.(..(((((((((((((....).)))).)))).....))))...)))..).....(((((.....)))))........)))....))).))).....).))))......).)))))...)).)))).))).(...((.((.........(.......((.(((((....))))).))....)..........)).))............(((((..........)))))........)..))))).....(.(((.((.......)).))).)......))...)))))))))).))..(.(..((.(..((((.((..(.(((((((..(((...(((.((...(((((((((((.(((..))).))))).).)))))...)).)).)..)))..))))))))..)).))))...).))...)..)..(((((((((....)))))))))}........ 80S ribosome from mouse bound to eEF2 (Class II); 28S rRNA 7ls1 n2 75 3.3 RF00005 URS0000326EAC_10090 34815424 0030533 0006412 10090 agcagaguggcgcagcggaagcgugcugggcccauaacccagaggucgauggaucgaaaccauccucugcuacca <<<<<<<..<<...........>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((.(.......).)).(((((.......))))).....(((((.......)))))))))))).... 80S ribosome from mouse bound to eEF2 (Class II); tRNA 7ls2 A2 3706 3.1 RF02543,RF02540 URS00023119A3_10090 34815424 0003735 0005840 10090 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccgcgcgucgcggcgugggaaauguggcguacggaagacccacuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugagnccgguagcggcccccggcgcgccgggcucgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaanggaaaguugaaaagaacuuugaagngagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcguccggccgugccggugguccggcggaucuuucccgcgcgggggaccgcccccggccggcgaccggccgccgccgggcgcacuuccaccguggcggugcgccgcgaccggcuccgggacggccgggaaggcccgguggggaagguggcucggggggggcucaccccgaguguuacagcccuccggccgcgcuuuucgccgaaucccggggccgaggaagaccgucgccgcncucucccucucccgggugggggccgggccgccccucccacggcgcgaccgcuccggggcggacuguccccagugcgccccgggcgucgucgcgccgucgggucccgggggcgucggucacgcgugacgaagccgagcgcacggggucggcggcgaugucggcuacccacccgacccgucuugaaacncggaccaaggagucuaacgcgugcgcgagucaggggcucguccgaaagccgccguggcgcaaugaaggugaagggccccgcccgggggcccgaggugggaucccgaggccucuccaguccgccgagggngcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcguacgcguuagnacccnanagauggugancuaugcuugggcagggcgaagccagaggaaacucuggugnagguccguagcgguccugacgugcaaaucgnucguccgaccuggguauagnggcgaaagacuaaucgaaccaucuaguagcuggnucccuccgaaguuucccucaggauagcuggcgcucucgcuacgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaaungguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuuggnaagcngaacuggcgcuncgggaugaaccgaacgccggguuaangcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggaugncgcuggagcgucgggcccauacccggccgucgccggcagucggaacggaacgggacgggagcggcgucgggccccgcggagccuacgccgcgacgaguaggagggccgcugcgnugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguagunnnaaauauucaaacgagaacuuugaaggccgaaguggngaaggguuccaugugaacagnanuugaacaugggucagucgguccugagagaugggcgagugccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucgnguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccucggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcnccgggccguaccnauauccgcagcaggucuncaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagcnggauccguaacuucgggauaaggauuggcucuaagggcugggucggucgcggccggcgccuagcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugccnagugcucugaaugucanagugnagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagcnaanugccucnucaucuaauuagugacgcgcaugaauggaugancgagauucccacugucccuaccuacuauccagcgaaaccacngncaagggaacgngcuuggnggaaucagcggggaaagaaganccuguugagcuugacucuagucuggcacggugaagagacaugagagguguagaauaagugggaggcccggccgccggugaaauaccacuacucucaucguuuuuucacugacccggugaggcgggggggcgagccccgaggggcucucgcuucuggcgccaagcguccgucccgcgcgugcgggcgggcgcgacccgcuccggggacagugccaggugggnaguuugacngnggcgguacaccugucaaacgguancgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucagnacgaauacagaccgugaaagcggggccunacgauccuucugaccuuuungguuuuaagcaggannugucagaaaaguuaccacagggauaacuggcuuguggcggccangcguucauagcgacgucgcuuuuugauccuungaugucggcucuuccuaucauugugaagcagaauunaccaagcguungauuguucacccacuaauagggaacgugagcuggguuuagancgucgugagacagnuuaguuuuacccuacugaugnuguguuguugccaugguaauccugcncaguacgagaggaaccgcagguncanacauuugguguaunugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgaggagccucgguuggccccggauagccggguccccguccguccccgcucccgggcgucgggaccgggguccgguncngagagccguucgucuugggaaacggggugcggccggaaagggggccgcccucucgcccgucacguugacgcacguucguguggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..[[[...<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>...<<<<<<<<<....<<<<<<<<.<......<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>..>>>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<......>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<..<<.....<<<<<<<<<<.<<<.<<<.<<<<<.<.....<<<<.<<<..<<<<<>>>>>>>>>>>>.>>>>>>>>>....>>>.>>>>>>>>>>......>.>.>>>.>>>>>...<<<<<<<.<<<<<<<<<<<<<<<...<<.<<<<.<<..<<<......<<<<<<<<.<....>.>>>>>>>>........>>>>>>>>>.......>>>>>>..>>>>>>>>>>>...............<<<<<<.<<<<..<<..>>..>>>>...<<<.<<<.<.<<<<<<<<<<<<<<<<<..<<<<<<..............>>>>>>.>>>>..>>>>>>>>>>.>>>....>>>..>>>>.....<<.....>>.....>>>>>>......>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<.....>>>>>>>..<<<<<...<<<..<<<...(((.[...>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<<...<<<<<<<....>>>>>>>...>.>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<.......<<<.<<<<<<<<<...<<<....<<<..<.<<<<...<<<<.<<...>>.>>>>.>>>>.>..>>>...>>>...>>>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>>>>>>.>>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<.............].)))...<<.<<.>>>>..................>>>>>>>>>....>>>>>>...<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<<<<<...>>>>>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<...<<<<<<<....>>>>>>>...<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<<.<<<<<<<<<..{{{..>>>>>>....<<<<<.<<<<.<<<......<<<.....>>>......>>>>>>>..>>>>>.....<<<<<<<<<..>>.>>>>>>>>>>..>.>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<..<<<.<<..>>.>>>.......>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<.<<..<<<.....<<<<....>>>>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<..<<<<<<<<.<<<<<<<<<<<<<<<<<...........<<<<..<<<<.>>>>............>>>>..>>>>>>>.>>>>>>>>>>...<<<<<.....<<<.<..<.<<<<.<<...>>>>>>.>..............<<<<<<<.<<<<<....>>>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>...>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<.....<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>.....<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..(((..>>>>>>.)))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]].....<<<<<<....<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<}}}.>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>.....>>>>>>.....<<<<<<.<<<..<<.<....<<<........<<<<<<.<<<<<..<..<.<.........>.>....>..>>>>>>>>>>>.......>>>...<<<..<<<<......<<.<<<<<<........>>>>>>>>.....>>>>..>>>...............>.>>..>>>>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<....<<<<<......>>>>>...>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((...((((((((((.....)))))).)))).....)))....(((((((((....(((.(((.((......((((((((..(.((((......)))))....[[(...).(((.....]])))...).)))))))..)))).))))...)))))))))..)....(((((((........))))))).....(.(((..[[[[[[)).))..)))..................................((....))............(..((((....))))............).....................(((.((((..(((.((...((((((((..(......((((((((((.(((..((.(((((.(.....((((.(((..((((()))))))))))).)))))))).....))).))))))))))........).))).)))))...((((((((((((((((((((.(.(..((.((((.((...((.......(((((((..(().).))))))).........)).)))))).......))).))..)))))))))))...............((((((.(((...((()))...)))...(((.(((.(..(((((((((((((((.(.((.((................)).))).)))..)))))))))).)).....)))..)))).....((.....)).....)))))).....))).)))))...)))))...)))).))).[((((........))))((((((....(((((((((((((..(((..(((((........))))..)..)))...((....))...(((((((.....)))))))..(((((...(((..(((..[[[[.[[.[)))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((.(((((.((((...(((((((....)))))))...)<)))...(((..((.((........)))).)))..).)))).)))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((.......(((.((((((((.....(.....(((..(.((((.(.(.((.((...)).)).)))))).)..)))...)......))))))...(((((((((.(......))))))))))....))))))))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.(((.((((((.....{.(((((.(((...((.........))...))).......(.((......)).).)))))...)))))).))))))..........]]].)....))))))))))...)))))))((((((.(((..........].]].]]].]..(.((.)))......(...)........)))))))))....)))))).(.(((((..(.((......((((.((((....))))))))...)))..)))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...(.....(((....)))..........((.((((((.((...)).)))))))).......)....))...(((((........)))))]]((((....(((((...((.((((....)))).))..((((....)))...(...((((((...(((((((((((((.(((((((((..{{{..))))))....(((((.((((.(((......(((.....)))......)))))))..))))).....(((.(((((..)).))).))))).).).))))))))))))(...)....))))))...)).........)).))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.((((((((((.(..(..((()))..)........)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((..((.....(......(((......)))......)...))...)))))(((((.........)))))........((...........((((.......))))...)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((...(((((((.(((((((((((((((((...........(((.(.(((...)))............))))..))))))).))))))))))...(((((.....((.(...(.(((.(((...)))))).)..............(((.(((.(((((....)))))))).)))...)))..)))))....)))))))....)))))..(((......[)).)(((((...........].)))))(.((...(..((((.(.((((((.......))))))...).((...[[[))....))))...)(..((..((((....{..))))..)).)(((....))).))]]].......((.(((..(((..]]]]]].)))))).))....)}....))))..)))))).......(....(..(((((...((.......))...)))))....)....)........((((.((((((..(.(...(((......))).....).).(((.........))).....)))))..)...))).).....(((((((....))).))))....))..))).))))).....((((((....(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}}.)))))..)).))...))))...)))).((((...((((.....}.......))))...))))..))).....)))))).....((((((.(((...(.(.(..(((........((((((.(((((..(..(.((.(....))).)....)..))))))))))).......)))...(((..((((.....(.(.((((((........))))))).)....))))..)))............)..).)...)))))))))(((((.(..(.......)..)....((.(((((((.((.....((((.(..(((((......)))))..)))))....))....)))).))).))..))))).. 80S ribosome from mouse bound to eEF2 (Class I); 28S rRNA 7ls2 B2 120 3.1 RF00001 URS00000F9D45_10090 34815424 0003735 0005840 10090 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((.(((...(....)...)).)..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. 80S ribosome from mouse bound to eEF2 (Class I); 5S rRNA 7ls2 C2 156 3.1 RF00002 URS00004B2C76_10090 34815424 0003735 0005840 10090 cgacucuuagcggnggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<<<<....>>>>.....<.<<<......>>.............>>>..>...>>>....<<....>><<<<<<<<<.....>>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))((((((((.......)))))))).................... 80S ribosome from mouse bound to eEF2 (Class I); 5.8S rRNA 7ls2 m2 1724 3.1 RF01960,RF01959,RF00177 URS00023119FF_10090 34815424 0003735 0005840 10090 uaccugguugauccugccaguagcaunugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuauggunccuuuggucgcucguacuuggauaacugugguaauucuagngcuaauacaugccgacgggcgcugaccccccuucccggggggggaugcgugcauuuaucagauggugacucuagauaaccucgggccgaucgcacgccccccguggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugangaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauancguauauuaaaguugcugcaguunaaaagcucguaguungaucuugggagcgggcguccccgcccucucggcggggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagancgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacncaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccugcgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggugcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucgnaacaagguuucnguaggugaaccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<...<....<<....<<..........>>...>>.>.......<<........<<<.<.<..<<....<<<<<.........<<..<...<..<.......>..>......>>>.........<<<<...<<<<<<<....>>>>>>>...>>>><<..<<<<<....<......>..>>>>>......>>...<<<<.<<<<......>>>>>>>>.>>.>>>...>>>.>.>>>.<<<....<<<......<<<<<.........>>>>>..>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<<..>>>.>...>>>>>>.........<<<....<<<.....>>>..>>>..>...>>.>.....<<<<<<<<<.<<.......>>.>>>>>.>>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.............<<<..>>>.....<..<............>.>...<<<<<<.<.......<<...<.......>..<<.........>.>...>>......>.>>>..>>>........<.<..<<<<<<<...............>>>>>>>..>.>..........<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<....<...<<<<.........>>>>...>.>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<<....>>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<.<<<<.<<<<<<......<<........>>..........<<<<<......<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<......>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<.......>>>>.>>>>.....>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.......>>>>>...>>.>>>>.>>>.>...<<.<<<........<.......<<<<<<<<....>>>>>>>>....>.........>>>.>>............<<<<<..........>>>>>...........>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<...<<<.<<...<<<<<.<<<<<<<<<..>>>>>>>>>...>>>>>...>>.>>>...>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..(......(((.(((..(.....((....((..........))...))[.)......(((.......(((.(....((....(((.......[...((......(.(((.....)))..)......)).........((((...(((((((....)))))))...))))((..(((((....(......)..)))))......)).(]((((.((((......)))))))))...)))...))..).))).(((....(((......(((((.........)))))..)))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).......(.(((...((((.]...))).))))).)...)).).....(((((((((.(.(....)..).))))).))))....(.((..(...........)..))......)..((((([[....(.((((.....((..]])).......))))))))))..)))))).)))..[......(.([[...(.(.((....((..(......(..((((....)))).)...(............)......(((((.(........(..((.......))..((.......).)....).......).)))..)).........(..(.(((((((...............)))))))..).).....)...(((.((...(...((((..(((.((((((((...((........))......)))))))).))).......((....))...))))..)...))..))..)))....)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.((.((....)).)))))))).)..)))....(..]].)...))...].))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((.......(........)...........(((((..(...((((((.......((.(((........))).)).....))))))....(.(((...(.((((((....(((.((.((....))...(.((......)))...)).)))....(((...(...((.(..(((((((((((((....).)))).)))).....))))..).))..).....(((((.....)))))........)))....))).))).....).))))......).)))))...)).)))).))).(...((.(((........(.......((((((((....))))))))....).........))).))............(((((..........)))))........)..))))).....(.(((.((.......)).))).)......))...)))))))))).))..(.(..((.(..((((.((..(.(((((((..(((..(.((.((...((.((.(((((((((..)))))))))...)).))...)).)).)..)))..))))))))..)).))))...).))...)..)..(((((((((....)))))))))}........ 80S ribosome from mouse bound to eEF2 (Class I); 18S rRNA 7ls2 n2 75 3.1 RF00005 URS0000326EAC_10090 34815424 0030533 0006412 10090 agcagaguggcgcagcggaagcgugcugggcccauaacccagaggucgauggaucgaaaccauccucugcuacca <<<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.......)))).(((((.......))))).....(((((.......)))))))))))).... 80S ribosome from mouse bound to eEF2 (Class I); tRNA 7lv0 3 1539 3.2 RF00177,RF01959,RF01960 URS000080DDC0_83333 34330903 0003735 0005840 83333 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<..<<....>>..>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<.<.<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>..<<.<<<<<.......<<<<<<<<<.......>>>>>>>>.>........>>>>>....>>.<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((..(............)...)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((........))))......)).).....(((....)))....((((((..(......))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....(((.((((.......)))).))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((..(((.(((....))).))).............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....))))))))..)).)))))))).(...((((((......(((..((...(((....)))...))....)))......))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((..((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}........... Pre-translocation rotated ribosome +1-frameshifting(CCC-A) complex (Structure Irot-FS); 16S ribosomal RNA 7lv0 1 2903 3.2 RF02540,RF02541 URS0000BC4674_83333 34330903 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugucgaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<....<.<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>..>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<<..>>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<.......>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<.........>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<......>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.......<<<<<..<<....>>...>>>>>.......>>>>>>>>>..>>>>>.<<<<<.......>>>>.>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<.............<<<...<.......<<<<<<<......>>>>>>>....>.............>>>....>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. (.((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......((((((((((.((.(((...(((((......)))))[[......(((.....]])))...)))...)).))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((((..)))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...).)))...(((.(((((........))))))))..).))))))))).(.((.......))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((.((.......)).).))...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(.(.........).)..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((..(......)..)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((...(((...(((....)))...)))...)))..(((((........)))))]]((((((((((.((...((((....((((..(((..(((((.((((((...{{{.).))))).((..((((...(((((.((((((.((.....)))))))).)..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...)).....)))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((....(((....])))....)))...))))))(...).......(((((((((...((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(.(((.........))).)........((.(......).(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((((.((((.(..(.(..........((.(............(..((((....))))..)...................).)).).)..).)))).))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....((.((((.((..]]]]..)))))).)).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))).). Pre-translocation rotated ribosome +1-frameshifting(CCC-A) complex (Structure Irot-FS); 23S ribosomal RNA 7lv0 2 120 3.2 RF00001 URS00008116C5_83333 34330903 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((.............))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Pre-translocation rotated ribosome +1-frameshifting(CCC-A) complex (Structure Irot-FS); 5S ribosomal RNA 7lv0 5 77 3.2 RF00005 URS00002E063F_83333 34330903 0030533 0006412 83333 cggcgaguagcgcagcuugguagcgcaacugguuugggaccagugggucggagguucgaauccucucucgccgacca <<<<<<<..<<<<.........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Pre-translocation rotated ribosome +1-frameshifting(CCC-A) complex (Structure Irot-FS); tRNAPro 7lv0 6 77 3.2 RF00005 URS000041AF00_83333 34330903 0030533 0006412 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(.(((.......))).)))))))..... Pre-translocation rotated ribosome +1-frameshifting(CCC-A) complex (Structure Irot-FS); tRNAfMet 7lv0 4 18 3.2 34330903 83333 aggagguaaaaaugccca .................. .................. Pre-translocation rotated ribosome +1-frameshifting(CCC-A) complex (Structure Irot-FS); mRNA 7lvk I 2898 2.2 RF02540,RF02541 URS00004B0F34_562 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccuu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<....<.<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>..>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<...>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<..<<....>>..>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<....<....>.....>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<...<............<<<<<..<<<.......<<<<<<<....>>>>>>>....>>>............>>>>>...>...>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>.(<<...<<<<<<<...<<<<<<.......>>>>>>.....<<)..(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>.. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((....((.......).)....)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{...(((..(...(((.........)))...)......(...((......)).).))).....)))..))))).))...........]]].)...))))))))))...)))))))((((((..........))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(...((((....))))....))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((.((.....(.(..........(((...(((.......(((..((....))..)))....))).............))).).).....)).)))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(.(((((....))).)).)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))).. Cfr-modified 50S subunit from Escherichia coli; 23S rRNA 7lvk J 118 2.2 RF00001 URS0000049E57_562 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))). Cfr-modified 50S subunit from Escherichia coli; 5S rRNA 7m2t P 10 2.71 URS0000A7631E_12881 34866603 12881 aaaaaaaaaa .......... .......... Crystallographic Structure of the Monoclinic Form of Satellite Tobacco Mosaic Virus; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 7m2t Q 10 2.71 URS0000A7631E_12881 34866603 12881 aaaaaaaaaa .......... .......... Crystallographic Structure of the Monoclinic Form of Satellite Tobacco Mosaic Virus; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 7m2t R 10 2.71 URS0000A7631E_12881 34866603 12881 aaaaaaaaaa .......... .......... Crystallographic Structure of the Monoclinic Form of Satellite Tobacco Mosaic Virus; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 7m2t S 10 2.71 URS0000A7631E_12881 34866603 12881 aaaaaaaaaa .......... .......... Crystallographic Structure of the Monoclinic Form of Satellite Tobacco Mosaic Virus; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 7m2t T 10 2.71 URS0000A7631E_12881 34866603 12881 aaaaaaaaaa .......... .......... Crystallographic Structure of the Monoclinic Form of Satellite Tobacco Mosaic Virus; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 7m2t U 10 2.71 URS0000A7631E_12881 34866603 12881 aaaaaaaaaa .......... .......... Crystallographic Structure of the Monoclinic Form of Satellite Tobacco Mosaic Virus; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 7m2t V 10 2.71 URS0000A7631E_12881 34866603 12881 aaaaaaaaaa .......... .......... Crystallographic Structure of the Monoclinic Form of Satellite Tobacco Mosaic Virus; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 7m2t W 10 2.71 URS0000A7631E_12881 34866603 12881 aaaaaaaaaa .......... .......... Crystallographic Structure of the Monoclinic Form of Satellite Tobacco Mosaic Virus; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 7m2t X 10 2.71 URS0000A7631E_12881 34866603 12881 aaaaaaaaaa .......... .......... Crystallographic Structure of the Monoclinic Form of Satellite Tobacco Mosaic Virus; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 7m2t Y 10 2.71 URS0000A7631E_12881 34866603 12881 aaaaaaaaaa .......... .......... Crystallographic Structure of the Monoclinic Form of Satellite Tobacco Mosaic Virus; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 7m2t Z 10 2.71 URS0000A7631E_12881 34866603 12881 aaaaaaaaaa .......... .......... Crystallographic Structure of the Monoclinic Form of Satellite Tobacco Mosaic Virus; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 7m2t a 10 2.71 URS0000A7631E_12881 34866603 12881 aaaaaaaaaa .......... .......... Crystallographic Structure of the Monoclinic Form of Satellite Tobacco Mosaic Virus; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 7m2t b 10 2.71 URS0000A7631E_12881 34866603 12881 aaaaaaaaaa .......... .......... Crystallographic Structure of the Monoclinic Form of Satellite Tobacco Mosaic Virus; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 7m2t c 10 2.71 URS0000A7631E_12881 34866603 12881 aaaaaaaaaa .......... .......... Crystallographic Structure of the Monoclinic Form of Satellite Tobacco Mosaic Virus; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 7m2t d 10 2.71 URS0000A7631E_12881 34866603 12881 aaaaaaaaaa .......... .......... Crystallographic Structure of the Monoclinic Form of Satellite Tobacco Mosaic Virus; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 7m2t e 10 2.71 URS0001C1D8A6_12881 34866603 12881 uuuuuuuuuu .......... .......... Crystallographic Structure of the Monoclinic Form of Satellite Tobacco Mosaic Virus; RNA (27-mer) 7m2t f 10 2.71 URS0001C1D8A6_12881 34866603 12881 uuuuuuuuuu .......... .......... Crystallographic Structure of the Monoclinic Form of Satellite Tobacco Mosaic Virus; RNA (27-mer) 7m2t g 10 2.71 URS0001C1D8A6_12881 34866603 12881 uuuuuuuuuu .......... .......... Crystallographic Structure of the Monoclinic Form of Satellite Tobacco Mosaic Virus; RNA (27-mer) 7m2t h 10 2.71 URS0001C1D8A6_12881 34866603 12881 uuuuuuuuuu .......... .......... Crystallographic Structure of the Monoclinic Form of Satellite Tobacco Mosaic Virus; RNA (27-mer) 7m2t i 10 2.71 URS0001C1D8A6_12881 34866603 12881 uuuuuuuuuu .......... .......... Crystallographic Structure of the Monoclinic Form of Satellite Tobacco Mosaic Virus; RNA (27-mer) 7m2t j 10 2.71 URS0001C1D8A6_12881 34866603 12881 uuuuuuuuuu .......... .......... Crystallographic Structure of the Monoclinic Form of Satellite Tobacco Mosaic Virus; RNA (27-mer) 7m2t k 10 2.71 URS0001C1D8A6_12881 34866603 12881 uuuuuuuuuu .......... .......... Crystallographic Structure of the Monoclinic Form of Satellite Tobacco Mosaic Virus; RNA (27-mer) 7m2t l 10 2.71 URS0001C1D8A6_12881 34866603 12881 uuuuuuuuuu .......... .......... Crystallographic Structure of the Monoclinic Form of Satellite Tobacco Mosaic Virus; RNA (27-mer) 7m2t m 10 2.71 URS0001C1D8A6_12881 34866603 12881 uuuuuuuuuu .......... .......... Crystallographic Structure of the Monoclinic Form of Satellite Tobacco Mosaic Virus; RNA (27-mer) 7m2t n 10 2.71 URS0001C1D8A6_12881 34866603 12881 uuuuuuuuuu .......... .......... Crystallographic Structure of the Monoclinic Form of Satellite Tobacco Mosaic Virus; RNA (27-mer) 7m2t o 10 2.71 URS0001C1D8A6_12881 34866603 12881 uuuuuuuuuu .......... .......... Crystallographic Structure of the Monoclinic Form of Satellite Tobacco Mosaic Virus; RNA (27-mer) 7m2t p 10 2.71 URS0001C1D8A6_12881 34866603 12881 uuuuuuuuuu .......... .......... Crystallographic Structure of the Monoclinic Form of Satellite Tobacco Mosaic Virus; RNA (27-mer) 7m2t q 10 2.71 URS0001C1D8A6_12881 34866603 12881 uuuuuuuuuu .......... .......... Crystallographic Structure of the Monoclinic Form of Satellite Tobacco Mosaic Virus; RNA (27-mer) 7m2t r 10 2.71 URS0001C1D8A6_12881 34866603 12881 uuuuuuuuuu .......... .......... Crystallographic Structure of the Monoclinic Form of Satellite Tobacco Mosaic Virus; RNA (27-mer) 7m2t s 10 2.71 URS0001C1D8A6_12881 34866603 12881 uuuuuuuuuu .......... .......... Crystallographic Structure of the Monoclinic Form of Satellite Tobacco Mosaic Virus; RNA (27-mer) 7m2t 7 22 2.71 URS0001C1D8A6_12881 34866603 12881 uuuuuuuuuuuuuuuuuuuuuu ...................... ...................... Crystallographic Structure of the Monoclinic Form of Satellite Tobacco Mosaic Virus; RNA (27-mer) 7m2t QQ 10 2.71 URS0000A7631E_12881 34866603 12881 aaaaaaaaaa .......... .......... Crystallographic Structure of the Monoclinic Form of Satellite Tobacco Mosaic Virus; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 7m2t RR 10 2.71 URS0000A7631E_12881 34866603 12881 aaaaaaaaaa .......... .......... Crystallographic Structure of the Monoclinic Form of Satellite Tobacco Mosaic Virus; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 7m2t SS 10 2.71 URS0000A7631E_12881 34866603 12881 aaaaaaaaaa .......... .......... Crystallographic Structure of the Monoclinic Form of Satellite Tobacco Mosaic Virus; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 7m2t TT 10 2.71 URS0000A7631E_12881 34866603 12881 aaaaaaaaaa .......... .......... Crystallographic Structure of the Monoclinic Form of Satellite Tobacco Mosaic Virus; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 7m2t UU 10 2.71 URS0000A7631E_12881 34866603 12881 aaaaaaaaaa .......... .......... Crystallographic Structure of the Monoclinic Form of Satellite Tobacco Mosaic Virus; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 7m2t VV 10 2.71 URS0000A7631E_12881 34866603 12881 aaaaaaaaaa .......... .......... Crystallographic Structure of the Monoclinic Form of Satellite Tobacco Mosaic Virus; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 7m2t WW 10 2.71 URS0000A7631E_12881 34866603 12881 aaaaaaaaaa .......... .......... Crystallographic Structure of the Monoclinic Form of Satellite Tobacco Mosaic Virus; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 7m2t YY 10 2.71 URS0000A7631E_12881 34866603 12881 aaaaaaaaaa .......... .......... Crystallographic Structure of the Monoclinic Form of Satellite Tobacco Mosaic Virus; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 7m2t ZZ 10 2.71 URS0000A7631E_12881 34866603 12881 aaaaaaaaaa .......... .......... Crystallographic Structure of the Monoclinic Form of Satellite Tobacco Mosaic Virus; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 7m2t bb 10 2.71 URS0000A7631E_12881 34866603 12881 aaaaaaaaaa .......... .......... Crystallographic Structure of the Monoclinic Form of Satellite Tobacco Mosaic Virus; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 7m2t cc 10 2.71 URS0000A7631E_12881 34866603 12881 aaaaaaaaaa .......... .......... Crystallographic Structure of the Monoclinic Form of Satellite Tobacco Mosaic Virus; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 7m2t dd 10 2.71 URS0000A7631E_12881 34866603 12881 aaaaaaaaaa .......... .......... Crystallographic Structure of the Monoclinic Form of Satellite Tobacco Mosaic Virus; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 7m2t ee 10 2.71 URS0000A7631E_12881 34866603 12881 aaaaaaaaaa .......... .......... Crystallographic Structure of the Monoclinic Form of Satellite Tobacco Mosaic Virus; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 7m2t ff 10 2.71 URS0000A7631E_12881 34866603 12881 aaaaaaaaaa .......... .......... Crystallographic Structure of the Monoclinic Form of Satellite Tobacco Mosaic Virus; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 7m2t gg 10 2.71 URS0000A7631E_12881 34866603 12881 aaaaaaaaaa .......... .......... Crystallographic Structure of the Monoclinic Form of Satellite Tobacco Mosaic Virus; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 7m2t hh 10 2.71 URS0001C1D8A6_12881 34866603 12881 uuuuuuuuuu .......... .......... Crystallographic Structure of the Monoclinic Form of Satellite Tobacco Mosaic Virus; RNA (27-mer) 7m2t ii 10 2.71 URS0001C1D8A6_12881 34866603 12881 uuuuuuuuuu .......... .......... Crystallographic Structure of the Monoclinic Form of Satellite Tobacco Mosaic Virus; RNA (27-mer) 7m2t jj 10 2.71 URS0001C1D8A6_12881 34866603 12881 uuuuuuuuuu .......... .......... Crystallographic Structure of the Monoclinic Form of Satellite Tobacco Mosaic Virus; RNA (27-mer) 7m2t kk 10 2.71 URS0001C1D8A6_12881 34866603 12881 uuuuuuuuuu .......... .......... Crystallographic Structure of the Monoclinic Form of Satellite Tobacco Mosaic Virus; RNA (27-mer) 7m2t ll 10 2.71 URS0001C1D8A6_12881 34866603 12881 uuuuuuuuuu .......... .......... Crystallographic Structure of the Monoclinic Form of Satellite Tobacco Mosaic Virus; RNA (27-mer) 7m2t mm 10 2.71 URS0001C1D8A6_12881 34866603 12881 uuuuuuuuuu .......... .......... Crystallographic Structure of the Monoclinic Form of Satellite Tobacco Mosaic Virus; RNA (27-mer) 7m2t nn 10 2.71 URS0001C1D8A6_12881 34866603 12881 uuuuuuuuuu .......... .......... Crystallographic Structure of the Monoclinic Form of Satellite Tobacco Mosaic Virus; RNA (27-mer) 7m2t oo 10 2.71 URS0001C1D8A6_12881 34866603 12881 uuuuuuuuuu .......... .......... Crystallographic Structure of the Monoclinic Form of Satellite Tobacco Mosaic Virus; RNA (27-mer) 7m2t pp 10 2.71 URS0001C1D8A6_12881 34866603 12881 uuuuuuuuuu .......... .......... Crystallographic Structure of the Monoclinic Form of Satellite Tobacco Mosaic Virus; RNA (27-mer) 7m2t qq 10 2.71 URS0001C1D8A6_12881 34866603 12881 uuuuuuuuuu .......... .......... Crystallographic Structure of the Monoclinic Form of Satellite Tobacco Mosaic Virus; RNA (27-mer) 7m2t rr 10 2.71 URS0001C1D8A6_12881 34866603 12881 uuuuuuuuuu .......... .......... Crystallographic Structure of the Monoclinic Form of Satellite Tobacco Mosaic Virus; RNA (27-mer) 7m2t tt 10 2.71 URS0001C1D8A6_12881 34866603 12881 uuuuuuuuuu .......... .......... Crystallographic Structure of the Monoclinic Form of Satellite Tobacco Mosaic Virus; RNA (27-mer) 7m2t uu 10 2.71 URS0001C1D8A6_12881 34866603 12881 uuuuuuuuuu .......... .......... Crystallographic Structure of the Monoclinic Form of Satellite Tobacco Mosaic Virus; RNA (27-mer) 7m2t vv 10 2.71 URS0001C1D8A6_12881 34866603 12881 uuuuuuuuuu .......... .......... Crystallographic Structure of the Monoclinic Form of Satellite Tobacco Mosaic Virus; RNA (27-mer) 7m2v QQ 10 1.8 URS000080DF9E_12881 34866603 12881 uuuuuuuuuu .......... .......... Crystallographic Structure of the Rhombohedral Crystal Form of STMV Grown from Chloride; RNA (5'-R(P*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*U)-3') 7m2v S 10 1.8 URS0000A7631E_12881 34866603 12881 aaaaaaaaaa .......... .......... Crystallographic Structure of the Rhombohedral Crystal Form of STMV Grown from Chloride; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 7m2v h 10 1.8 URS000080DF9E_12881 34866603 12881 uuuuuuuuuu .......... .......... Crystallographic Structure of the Rhombohedral Crystal Form of STMV Grown from Chloride; RNA (5'-R(P*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*U)-3') 7m2v V 10 1.8 URS0000A7631E_12881 34866603 12881 aaaaaaaaaa .......... .......... Crystallographic Structure of the Rhombohedral Crystal Form of STMV Grown from Chloride; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 7m2v ww 10 1.8 URS000080DF9E_12881 34866603 12881 uuuuuuuuuu .......... .......... Crystallographic Structure of the Rhombohedral Crystal Form of STMV Grown from Chloride; RNA (5'-R(P*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*U)-3') 7m2v k 10 1.8 URS0000A7631E_12881 34866603 12881 aaaaaaaaaa .......... .......... Crystallographic Structure of the Rhombohedral Crystal Form of STMV Grown from Chloride; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 7m2v T 10 1.8 URS000080DF9E_12881 34866603 12881 uuuuuuuuuu .......... .......... Crystallographic Structure of the Rhombohedral Crystal Form of STMV Grown from Chloride; RNA (5'-R(P*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*U)-3') 7m2v U 10 1.8 URS0000A7631E_12881 34866603 12881 aaaaaaaaaa .......... .......... Crystallographic Structure of the Rhombohedral Crystal Form of STMV Grown from Chloride; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 7m2v X 10 1.8 URS0000A7631E_12881 34866603 12881 aaaaaaaaaa .......... .......... Crystallographic Structure of the Rhombohedral Crystal Form of STMV Grown from Chloride; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 7m2v m 10 1.8 URS000080DF9E_12881 34866603 12881 uuuuuuuuuu .......... .......... Crystallographic Structure of the Rhombohedral Crystal Form of STMV Grown from Chloride; RNA (5'-R(P*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*U)-3') 7m2v TT 10 1.8 URS0000A7631E_12881 34866603 12881 aaaaaaaaaa .......... .......... Crystallographic Structure of the Rhombohedral Crystal Form of STMV Grown from Chloride; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 7m2v i 10 1.8 URS000080DF9E_12881 34866603 12881 uuuuuuuuuu .......... .......... Crystallographic Structure of the Rhombohedral Crystal Form of STMV Grown from Chloride; RNA (5'-R(P*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*U)-3') 7m2v P 10 1.8 URS0000A7631E_12881 34866603 12881 aaaaaaaaaa .......... .......... Crystallographic Structure of the Rhombohedral Crystal Form of STMV Grown from Chloride; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 7m2v e 10 1.8 URS000080DF9E_12881 34866603 12881 uuuuuuuuuu .......... .......... Crystallographic Structure of the Rhombohedral Crystal Form of STMV Grown from Chloride; RNA (5'-R(P*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*U)-3') 7m2v Y 10 1.8 URS0000A7631E_12881 34866603 12881 aaaaaaaaaa .......... .......... Crystallographic Structure of the Rhombohedral Crystal Form of STMV Grown from Chloride; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 7m2v n 10 1.8 URS000080DF9E_12881 34866603 12881 uuuuuuuuuu .......... .......... Crystallographic Structure of the Rhombohedral Crystal Form of STMV Grown from Chloride; RNA (5'-R(P*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*U)-3') 7m2v ff 10 1.8 URS0000A7631E_12881 34866603 12881 aaaaaaaaaa .......... .......... Crystallographic Structure of the Rhombohedral Crystal Form of STMV Grown from Chloride; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 7m2v xx 10 1.8 URS000080DF9E_12881 34866603 12881 uuuuuuuuuu .......... .......... Crystallographic Structure of the Rhombohedral Crystal Form of STMV Grown from Chloride; RNA (5'-R(P*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*U)-3') 7m2v yy 10 1.8 URS000080DF9E_12881 34866603 12881 uuuuuuuuuu .......... .......... Crystallographic Structure of the Rhombohedral Crystal Form of STMV Grown from Chloride; RNA (5'-R(P*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*U)-3') 7m2v zz 10 1.8 URS0000A7631E_12881 34866603 12881 aaaaaaaaaa .......... .......... Crystallographic Structure of the Rhombohedral Crystal Form of STMV Grown from Chloride; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 7m3t e 11 3.2 URS000080DF9E_12881 34866603 12881 uuuuuuuuuuu ........... ........... Crystallographic structure of a cubic crystal of STMV (80.7 degree rotation about 111) grown from chloride; RNA (5'-R(P*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*U)-3') 7m3t bb 12 3.2 URS0000A7631E_12881 34866603 12881 aaaaaaaaaaaa ............ ............ Crystallographic structure of a cubic crystal of STMV (80.7 degree rotation about 111) grown from chloride; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 7m4v A 2732 2.54 RF02540,RF02541 URS000231197A_480119 34044590 0003735 0005840 480119 agucaaguaauuaagugcaugugguggaugccuuggcagucagaggcgaugaaagacgugauagccugcgaaaagcuccggggaggcggcaaauauccuuugauccggagaugucugaaugggggaacccaccuacuuuaagguagguauugcaacaugaauacauaguguugcaaggcgaacgaggggaagugaaacaucucaguacccuuaggaaaagaaaucaauugagauucccucaguagcggcgagcgaacggggaucagcccauuaaguuauguguguuuuaguggaacgcucugggaagugcgaacguagagggugauauucccguacacgaaagggcacacauaaugaugacgaguagggcgaggcacgugaaaccuugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccugugaggggagugaaauagauccugaaaccgcaugcauacaagcagugggagcaccuucguggugugacugcguaccuuuuguauaaugggucagcgacuuauauucaguagcgagguuaaccguauaggggagccguagagaaaucgagucuuaauagggcguuuaguugcuggguauagacccgaaaccaggcgaucuauccaugagcagguugaagguuggguaacacuaacuggaggaccgaacccacugucguugaaaagccaggggaugacuuguggauaggggugaaaggcuaaucaagccuggugauagcugguucuccccgaaagcuauuuagguagcgccucggacgaauaccauaggggguagagcacuguuucggcaccgaugcaaacuccgaauaccuaugaguacuauccgggagacagacugcgggugcuaacguccguagucaagaggaaaacaauccagaccgccagcuaaggccccaaaaucauaguuaagugggaaacgaugugggaaggcauagacagcuauagucgagucggccugcgcggaagauguaacggggcuaaaacuaugugccgaagcugcggauguauacuuuguauacgugguaggggagcguucuguaagccgaugaagguguguugagaagcaugcuggagguaucagaagugcgaaugcugacgugaguaacgacaaaacgggugaaaaacccguucgccgaaagaccaaggguuccaguccaacguuaaucggggcugggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaaaugguuaauauuccauuacuucuguguaaugcgaugagaggacggagaaggcuaaaucagccuggcguugguuguccaggugaaaggauguaggcauguaucuuaggcaaauccgggguacucuaugcugagaucugauagcaagcuguacuugugcagcgaagugguugaugccaugcuuccaggaaaagucucuaagcuucaguuacacaggaaucguacccgaaaccgacacagguggucaggucgaguagaccaaggcgcuugagagaacucugcugaaggaacuaggcaaaaugguaccguaacuucgggagaagguacgcuguuguuggugauggaacucgcuuccugagcugacgacagccgcagaaaccaggccgcugcaacuguuuauuaaaaacauagcacucugcaaacacgaaaguggacguauagggugugaugccugcccggugcuggaagguuaauugaugggguuagcguaagcgaagcucuugaucgaagccccaguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgaccugcacgaauggcauaaugauggcggcgcugucuccagcagaggcucagugaaaucgaaaucgcugugnagaugcaguguacccgcggcuagacggaaagaccccgunaaccuuuacugcagcuugacacugaacuuugauugagguucuaacucugucccgugauccgggacgaggaccgugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggaguacgaaggugcgcucagcguggucggaaaucacgcguagaguauaaaggcaaaagcgcgcuuaacugcgagacccacaagucgagcagguacgaaaguaggucuuagugauccggugguucuguauggaagggccaucgcucaacggauaaaagguacucugnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgnugucggcucaucucauccuggggcugaagcaggucccaaggguauggcnguucgccauuuaaagagguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucuaccgugggcgcuggaaauuugagaggaucugcuccuaguacgagaggaccagaguggacgaaccucugguguaccgguugugacgccagucgcaucgccggguagcuauguucggaagggauaaccgcugaaagcaucuaagcgggaagccuaccucaagauaagauuucccuaggacuuuauguccucuaaagagccguucgagacuaggacguugauagguuggauguggaagcauagugauaugugaagcugaccaauacuaauugcucgugaggcuugacua 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.((((((([.....((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(..]]]...]...)......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.....((((((((((((((.(((...(((.(......).)))[[(...).(((.....]])))...)))...))))))))))))))......)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((.....)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((.(.......<).))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).(((((((...((((((((((.....(((...(((.((((..)))).)))..)).).....)))))).))).).)))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{..((()))....)))..))))).))...........]]].)....))))))))))...)))))))((((((((...))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))....((((...((((.(((((((.((.....)))))))))....))))..[)))).....(..((((((....))))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((...((((....]))))...))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..(((((((..(((.((......(((..((((((..(((((.(((.(((((.((((((.(()).))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((....((((.........))))......((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..)).)))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(.(((((....))).)).)..>.))..))).)))))))[...(((((((...((((..((((((......(....).....)))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..)])))))(....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))..).)))))))).. A. baumannii Ribosome-Eravacycline complex: 50S; 23s ribosomal RNA 7m4v B 115 2.54 RF00001 URS00002D8B10_480119 34044590 0003735 0005840 480119 gcuggcgaccauagcaagagugaaccaccugaucccuucccgaacucagaagugaaaccucuuagcgcugaugguagugugggauuacccaugugagaguaagucaucgccagcu <<<<<<<<.....<<<<<<<.....<<<<<<...............>>>..>>>....>>>>>.>><<<.......<<<<<<<....>>>>>>>.......>>>..>>>>>>>>. ((((((((.....(((((((.....((((((....(.....)....)))..)))....))))).))(((.......(((((((....))))))).......)))..)))))))). A. baumannii Ribosome-Eravacycline complex: 50S; 5s ribosomal RNA 7m4w A 2730 2.55 RF02540,RF02541 URS000231197A_480119 34044590 0003735 0005840 480119 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<<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<.)))...]..>>.....>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<......<<<<<<<<<<<<<..<<<...<<<.<......>.>>>((......<<<.....))>>>...>>>....>>>>>>>>>>>>>...........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..>>>......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<<.....>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<.<........>.>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<....<<<<<<<<<.....<<<...<<<.<<<<..>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<.........<<..>>.....>>..>>>>>.>>...........)))......>>>>>>.>>>...>>>>>>><<<<<<<<...>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<...((((...>>>>>>....<<<<...<<<<.<<<<<<..<<.....>>.>>>>>>....>>>>...>>>>........<<<<<......>>>>>....>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<....<<..>>.....>>>>><<<<<<<<<<<<...<<<<.....>>>>...>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.......<<<<<<.<<....>>..>>>>>>.......>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<.<<<<.[[......<<<<.[[<<<<..<<<<..<<<.<<<<<.<<<<<<<<..>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>...>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<.................>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))))>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<<<<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>...>>>>..>..>>>>>>>. ((((((([.....((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...((.]]]...]..))......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((..(..((.(((((((..((.(((...(((.(......).)))[[(...).(((.....]])))...)))...))..))))))).))...)..)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((.....)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((.(.......<).))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).(((((((...((((((((((.....(((...(((.((((..)))).)))..)).).....)))))).))).).)))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{..((()))....)))..))))).))...........]]].)....))))))))))...)))))))((((((((...))))))))....))))))(((((((...(((......((((((((....))))))))...)))..))))).)).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]]((((((((((.((...((((....((((..(((..((((((((((((...{{{.).))))))....(((....((((.(((((.(.((.....))).)))))....))))..[.))).....(..((((((....))))))...))))))...)))...))))(..).....))))...)).....)))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((...((((....]))))...))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..(((((((..(((.((......(((..((((((..(((((.(((.(((((.((((((.(()).))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..)).)))......((((..(.((((((...((.......))...))))))...).)).).).....((.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..))....(.(((((....))).)).)..>.))..))).)))))))[...(((((((...((((..((((((......(....).....)))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..)])))))(....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))..).)))))))). A. baumannii Ribosome-Eravacycline complex: Empty 70S; 23s ribosomal RNA 7m4w B 115 2.55 RF00001 URS00002D8B10_480119 34044590 0003735 0005840 480119 gcuggcgaccauagcaagagugaaccaccugaucccuucccgaacucagaagugaaaccucuuagcgcugaugguagugugggauuacccaugugagaguaagucaucgccagcu <<<<<<<<.....<<<<<<<.....<<<<<<<.............>>>>..>>>....>>>>>.>><<<.......<<<<<<<....>>>>>>>.......>>>..>>>>>>>>. ((((((((.....(((((((.....(((((((...(.....)...))))..)))....))))).))(((.......(((((((....))))))).......)))..)))))))). A. baumannii Ribosome-Eravacycline complex: Empty 70S; 5s ribosomal RNA 7m4w a 1528 2.55 RF00177,RF01959,RF01960 URS00023119FB_480119 34044590 0003735 0005840 480119 uaacugaagaguuugaucauggcucagauugaacgcuggcggcaggcuuaacacaugcaagucgagcgggggaagguagcuugcuaccggaccuagcggcggacgggugaguaaugcuuaggaaucugccuauuagugggggacaacaucucgaaagggaugcuaauaccgcauacguccuacgggagaaagcaggggaucuucggaccuugcgcuaauagaugagccuaagucggauuagcuaguuggugggguaaaggccuaccaaggcgacgaucuguagcgggucugagaggaugauccgccacacugggacugagacacggcccagacuccuacgggaggcagcaguggggaauauuggacaauggggggaacccugauccagccaugccgcgugugugaagaaggccuuaugguuguaaagcacuuuaagcgaggaggaggcuacucuaguuaauaccuagggauaguggacguuacucgcagaauaagcaccggcuaacucugugccagcagccncgguaauacagagggugcgagcguuaaucggauuuacugggcguaaagcgugcguaggcggcuuauuaagucggaugugaaauccccgagcuuaacuugggaauugcauucgauacuggugagcuagaguaugggagaggaugguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgauggcgaaggcagccaucuggccuaauacugacgcugagguacgaaagcauggggagcaaacaggauuagauacccugguaguccaugccguaaacgaugucuacuagccguuggggccuuugaggcuuuaguggcgcagcuaacgcgauaaguagaccgccuggggaguacggucgcaagacuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggccuugacauacuagaaacuuuucagagauggauuggugccuucgggaaccuagauacaggugcugcauggcugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuuuuccuuacuugccagcauuucggaugggaacuuuaaggauacugccagugacaaacuggaggaaggcggggacgacgucaagucaucaugncccuuacggccagggcuacacacgugcuacaauggucgguacaaaggguugcuacacagcgaugugaugcuaaucucaaaaagccgaucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucgcggaucagaaugccgcggugaauacguucccgggccuuguacacaccgnccgucacaccaugggaguuuguugcaccagaaguagcuagccuaacugcaaagagggcgguuaccacgguguggccgaugacuggggugaagucgnaacaagguagccguaggggnnccugcggcuggauc ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<<...<<<<<<..>>>>>>...>>>.>>>>>......<<.......<<<<<<<..<<...<<<<<<<<<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>>>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<<<<<<<<<<.......>>>>>>.>>>>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<<...>>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<...<..<<<<....>>>>..>...<<....>>...>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<<..<<<.....>>>>>.....>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<.<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>.>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((...((((((..))))))...))).)))))......(((......(((((((..((...(((((((((.((.....((((((....))))))......)).).....(((....)))....((((((..((....))))))))))))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(..((((((((((.......)))))).))))...)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((((((...)))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((...(..(.((....)).)..)...((....))...)))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.((((((....((..(((.....))))).....))))))..(..((((.......)))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((.((((((((....((((((.((((..((....)).))))))))))...)))))))).)))..))).))))..).))...)..)..(((((((((....)))))))))}.... A. baumannii Ribosome-Eravacycline complex: Empty 70S; 16s Ribosomal RNA 7m4x A 2730 2.66 RF02540,RF02541 URS000231197A_480119 34044590 0003735 0005840 480119 gucaaguaauuaagugcaugugguggaugccuuggcagucagaggcgaugaaagacgugauagccugcgaaaagcuccggggaggcggcaaauauccuuugauccggagaugucugaaugggggaacccaccuacuuuaagguagguauugcaacaugaauacauaguguugcaaggcgaacgaggggaagugaaacaucucaguacccuuaggaaaagaaaucaauugagauucccucaguagcggcgagcgaacggggaucagcccauuaaguuauguguguuuuaguggaacgcucugggaagugcgaacguagagggugauauucccguacacgaaagggcacacauaaugaugacgaguagggcgaggcacgugaaaccuugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccugugaggggagugaaauagauccugaaaccgcaugcauacaagcagugggagcaccuucguggugugacugcguaccuuuuguauaaugggucagcgacuuauauucaguagcgagguuaaccguauaggggagccguagagaaaucgagucuuaauagggcguuuaguugcuggguauagacccgaaaccaggcgaucuauccaugagcagguugaagguuggguaacacuaacuggaggaccgaacccacugucguugaaaagccaggggaugacuuguggauaggggugaaaggcuaaucaagccuggugauagcugguucuccccgaaagcuauuuagguagcgccucggacgaauaccauaggggguagagcacuguuucggcaccgaugcaaacuccgaauaccuaugaguacuauccgggagacagacugcgggugcuaacguccguagucaagaggaaaacaauccagaccgccagcuaaggccccaaaaucauaguuaagugggaaacgaugugggaaggcauagacagcuauagucgagucggccugcgcggaagauguaacggggcuaaaacuaugugccgaagcugcggauguauacuuuguauacgugguaggggagcguucuguaagccgaugaagguguguugagaagcaugcuggagguaucagaagugcgaaugcugacgugaguaacgacaaaacgggugaaaaacccguucgccgaaagaccaaggguuccaguccaacguuaaucggggcugggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaaaugguuaauauuccauuacuucuguguaaugcgaugagaggacggagaaggcuaaaucagccuggcguugguuguccaggugaaaggauguaggcauguaucuuaggcaaauccgggguacucuaugcugagaucugauagcaagcuguacuugugcagcgaagugguugaugccaugcuuccaggaaaagucucuaagcuucaguuacacaggaaucguacccgaaaccgacacagguggucaggucgaguagaccaaggcgcuugagagaacucugcugaaggaacuaggcaaaaugguaccguaacuucgggagaagguacgcuguuguuggugauggaacucgcuuccugagcugacgacagccgcagaaaccaggccgcugcaacuguuuauuaaaaacauagcacucugcaaacacgaaaguggacguauagggugugaugccugcccggugcuggaagguuaauugaugggguuagcguaagcgaagcucuugaucgaagccccaguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgaccugcacgaauggcauaaugauggcggcgcugucuccagcagaggcucagugaaaucgaaaucgcugugnagaugcaguguacccgcggcuagacggaaagaccccgunaaccuuuacugcagcuugacacugaacuuugauugagguucuaacucugucccgugauccgggacgaggaccgugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggaguacgaaggugcgcucagcguggucggaaaucacgcguagaguauaaaggcaaaagcgcgcuuaacugcgagacccacaagucgagcagguacgaaaguaggucuuagugauccggugguucuguauggaagggccaucgcucaacggauaaaagguacucugnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgnugucggcucaucucauccuggggcugaagcaggucccaaggguauggcnguucgccauuuaaagagguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucuaccgugggcgcuggaaauuugagaggaucugcuccuaguacgagaggaccagaguggacgaaccucugguguaccgguugugacgccagucgcaucgccggguagcuauguucggaagggauaaccgcugaaagcaucuaagcgggaagccuaccucaagauaagauuucccuaggacuuuauguccucuaaagagccguucgagacuaggacguugauagguuggauguggaagcauagugauaugugaagcugaccaauacuaauugcucgugaggcuugacu <<<<<<<......<<<<<<<<<<<....<<<.<<<<<<<<<<<<<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<.)))...]..>>.....>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<......<<<<<<<<<<<<<<.<<<...<<<.<......>.>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>...........<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>>.>>>..............<<....>>....>>.........<<<<.....>>>>.............>....>>>>>>>>>>>.......<<<<..<<<<<.....>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<.<........>.>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<....<<<<<<<<<.....<<<...<<<.<<<<..>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<.........<<..>>.....>>..>>>>>.>>...........)))......>>>>>>.>>>...>>>>>>><<<<<<<<...>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<...[[[[...>>>>>>....<<<<...<<<<.<<<<<<..<<.....>>.>>>>>>....>>>>...>>>>........<<<<<......>>>>>....>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<...<<<<.....>>>>...>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<......<.<<<<<<.<<....>>..>>>>>>>.......>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<.<<<<.<<......<<<<.<<<<<<..<<<<..<<<.<<<<<.<<<<<<<<..>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>...>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<.................>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<<<<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>...>>>>..>..>>>>>>>. ((((((([.....((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...((.]]]...]..))......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((..(..((((((((((..((.(((...(((.(......).)))[[(...).(((.....]])))...)))...))..))))))))))...)..)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((.....)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((.(.......<).))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).(((((((...((((((((((.....(((...(((.((((..)))).)))..)).).....)))))).))).).)))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{..((()))....)))..))))).))...........]]].)....))))))))))...)))))))((((((((...))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))....(((....((((.(((((((.((.....)))))))))....))))..[.)))........((((((....))))))....)))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((...((((....]))))...))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..(((((((..(((.((......(((..((((((..(((((.(((.(((((.(((((((.(.))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))(.((...(((((((.(.(((((.........)))))...).((.[.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..)).)))......((((..(.((((((...((.......))...))))))...).)).).).....((.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..))....(.(((((....))).)).)..>.))..))).)))))))[...(((((((...((((..((((((......(....).....)))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..)])))))(....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))..).)))))))). A. baumannii Ribosome-Eravacycline complex: P-site tRNA 70S; 23s ribosomal RNA 7m4x B 115 2.66 RF00001 URS00002D8B10_480119 34044590 0003735 0005840 480119 gcuggcgaccauagcaagagugaaccaccugaucccuucccgaacucagaagugaaaccucuuagcgcugaugguagugugggauuacccaugugagaguaagucaucgccagcu <<<<<<<<.....<<<<<<<.....<<<<<<...............>>>..>>>....>>>>>.>><<<.......<<<<<<<....>>>>>>>.......>>>..>>>>>>>>. (((((((......(((((((.....((((((....(.....)....)))..)))....))))).))(((.......(((((((....))))))).......)))...))))))). A. baumannii Ribosome-Eravacycline complex: P-site tRNA 70S; 5s ribosomal RNA 7m4x a 1528 2.66 RF00177,RF01959,RF01960 URS00023119FB_480119 34044590 0003735 0005840 480119 uaacugaagaguuugaucauggcucagauugaacgcuggcggcaggcuuaacacaugcaagucgagcgggggaagguagcuugcuaccggaccuagcggcggacgggugaguaaugcuuaggaaucugccuauuagugggggacaacaucucgaaagggaugcuaauaccgcauacguccuacgggagaaagcaggggaucuucggaccuugcgcuaauagaugagccuaagucggauuagcuaguuggugggguaaaggccuaccaaggcgacgaucuguagcgggucugagaggaugauccgccacacugggacugagacacggcccagacuccuacgggaggcagcaguggggaauauuggacaauggggggaacccugauccagccaugccgcgugugugaagaaggccuuaugguuguaaagcacuuuaagcgaggaggaggcuacucuaguuaauaccuagggauaguggacguuacucgcagaauaagcaccggcuaacucugugccagcagccncgguaauacagagggugcgagcguuaaucggauuuacugggcguaaagcgugcguaggcggcuuauuaagucggaugugaaauccccgagcuuaacuugggaauugcauucgauacuggugagcuagaguaugggagaggaugguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgauggcgaaggcagccaucuggccuaauacugacgcugagguacgaaagcauggggagcaaacaggauuagauacccugguaguccaugccguaaacgaugucuacuagccguuggggccuuugaggcuuuaguggcgcagcuaacgcgauaaguagaccgccuggggaguacggucgcaagacuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggccuugacauacuagaaacuuuucagagauggauuggugccuucgggaaccuagauacaggugcugcauggcugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuuuuccuuacuugccagcauuucggaugggaacuuuaaggauacugccagugacaaacuggaggaaggcggggacgacgucaagucaucaugncccuuacggccagggcuacacacgugcuacaauggucgguacaaaggguugcuacacagcgaugugaugcuaaucucaaaaagccgaucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucgcggaucagaaugccgcggugaauacguucccgggccuuguacacaccgnccgucacaccaugggaguuuguugcaccagaaguagcuagccuaacugcaaagagggcgguuaccacgguguggccgaugacuggggugaagucgnaacaagguagccguaggggnnccugcggcuggauc ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<<...<<<<<<..>>>>>>...>>>.>>>>>......<<.......<<<<<<<..<<...<<<<<<<<<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>>>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<<<<<<<<<<.<...>.>>>>>>.>>>>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<<...>>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<...<..<<<<....>>>>..>...<<....>>...>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<<..<<<.....>>>>>.....>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<.<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>.>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((...((((((..))))))...))).)))))......(((......(((((((..((...(((((((((.((.....((((((....))))))......)).).....(((....)))....((((((..((....))))))))))))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(..((((((((((.......)))))).))))...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((((((...)))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((...(..(.((....)).)..)...((....))...)))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.((((((....((..(((.....))))).....))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((.((((((((....((((((.((((..((....)).))))))))))...)))))))).)))..))).))))..).))...)..)..(((((((((....)))))))))}.... A. baumannii Ribosome-Eravacycline complex: P-site tRNA 70S; 16s Ribosomal RNA 7m4x v 77 2.66 RF00005 URS00002D670D_480119 34044590 0030533 0006412 480119 ggcuaugnagcucaguuggnuagagcaccgcacucauaaugcgggggucacaagnucaagucucgucauagccacca <<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<.<<.......>>.>>>>>>>>>.... (((((((..((((.........)))).(((((.......))))).....((.((.......)).))))))))).... A. baumannii Ribosome-Eravacycline complex: P-site tRNA 70S; tRNA-met 7m4y A 2730 2.5 RF02540,RF02541 URS000231197A_480119 34044590 0003735 0005840 480119 gucaaguaauuaagugcaugugguggaugccuuggcagucagaggcgaugaaagacgugauagccugcgaaaagcuccggggaggcggcaaauauccuuugauccggagaugucugaaugggggaacccaccuacuuuaagguagguauugcaacaugaauacauaguguugcaaggcgaacgaggggaagugaaacaucucaguacccuuaggaaaagaaaucaauugagauucccucaguagcggcgagcgaacggggaucagcccauuaaguuauguguguuuuaguggaacgcucugggaagugcgaacguagagggugauauucccguacacgaaagggcacacauaaugaugacgaguagggcgaggcacgugaaaccuugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccugugaggggagugaaauagauccugaaaccgcaugcauacaagcagugggagcaccuucguggugugacugcguaccuuuuguauaaugggucagcgacuuauauucaguagcgagguuaaccguauaggggagccguagagaaaucgagucuuaauagggcguuuaguugcuggguauagacccgaaaccaggcgaucuauccaugagcagguugaagguuggguaacacuaacuggaggaccgaacccacugucguugaaaagccaggggaugacuuguggauaggggugaaaggcuaaucaagccuggugauagcugguucuccccgaaagcuauuuagguagcgccucggacgaauaccauaggggguagagcacuguuucggcaccgaugcaaacuccgaauaccuaugaguacuauccgggagacagacugcgggugcuaacguccguagucaagaggaaaacaauccagaccgccagcuaaggccccaaaaucauaguuaagugggaaacgaugugggaaggcauagacagcuauagucgagucggccugcgcggaagauguaacggggcuaaaacuaugugccgaagcugcggauguauacuuuguauacgugguaggggagcguucuguaagccgaugaagguguguugagaagcaugcuggagguaucagaagugcgaaugcugacgugaguaacgacaaaacgggugaaaaacccguucgccgaaagaccaaggguuccaguccaacguuaaucggggcugggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaaaugguuaauauuccauuacuucuguguaaugcgaugagaggacggagaaggcuaaaucagccuggcguugguuguccaggugaaaggauguaggcauguaucuuaggcaaauccgggguacucuaugcugagaucugauagcaagcuguacuugugcagcgaagugguugaugccaugcuuccaggaaaagucucuaagcuucaguuacacaggaaucguacccgaaaccgacacagguggucaggucgaguagaccaaggcgcuugagagaacucugcugaaggaacuaggcaaaaugguaccguaacuucgggagaagguacgcuguuguuggugauggaacucgcuuccugagcugacgacagccgcagaaaccaggccgcugcaacuguuuauuaaaaacauagcacucugcaaacacgaaaguggacguauagggugugaugccugcccggugcuggaagguuaauugaugggguuagcguaagcgaagcucuugaucgaagccccaguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgaccugcacgaauggcauaaugauggcggcgcugucuccagcagaggcucagugaaaucgaaaucgcugugnagaugcaguguacccgcggcuagacggaaagaccccgunaaccuuuacugcagcuugacacugaacuuugauugagguucuaacucugucccgugauccgggacgaggaccgugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggaguacgaaggugcgcucagcguggucggaaaucacgcguagaguauaaaggcaaaagcgcgcuuaacugcgagacccacaagucgagcagguacgaaaguaggucuuagugauccggugguucuguauggaagggccaucgcucaacggauaaaagguacucugnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgnugucggcucaucucauccuggggcugaagcaggucccaaggguauggcnguucgccauuuaaagagguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucuaccgugggcgcuggaaauuugagaggaucugcuccuaguacgagaggaccagaguggacgaaccucugguguaccgguugugacgccagucgcaucgccggguagcuauguucggaagggauaaccgcugaaagcaucuaagcgggaagccuaccucaagauaagauuucccuaggacuuuauguccucuaaagagccguucgagacuaggacguugauagguuggauguggaagcauagugauaugugaagcugaccaauacuaauugcucgugaggcuugacu <<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<.)))......>>.....>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<......<<<<<<<<<<<<<<.<<<...<<<.<......>.>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>...........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..>>>......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<.....>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<<...>>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<.<........>.>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<....<<<<<<<<<.....<<<...<<<.<<<<..>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<.........<<..>>.....>>..>>>>>.>>...........)))......>>>>>>.>>>...>>>>>>><<<<<<<<...>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<...((((...>>>>>>....<<<<...<<<<.<<<<<<..<<.....>>.>>>>>>....>>>>...>>>>........<<<<<......>>>>>....>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<<<<<<<...<<<<.....>>>>...>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.......<<<<<<.<<....>>..>>>>>>.......>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<.<<<<.[[......<<<<.[[<<<<..<<<<..<<<.<<<<<.<<<<<<<<..>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>...>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<.................>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))))>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<<<<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>...>>>>..>..>>>>>>>. ((((((([.....((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(..]]]...]...)......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((..(..((.(((((((((((.(((...(((.(......).)))[[(...).(((.....]])))...)))...))))))))))).))...)..)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((.....)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((.(.......<).))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).(((((((...((((((((((.....(((...(((.((((..)))).)))..)).).....)))))).))).).)))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((.((..(((.....{...(()).....)))..)).)).))...........]]].)....))))))))))...)))))))((((((((...))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]]((((((((((.((...((((....((((..(((..((((((((((((...{{{.).))))))....(((....((((.(((((((.((.....)))))))))....))))..[.))).....(..((((((....))))))...))))))...)))...))))(..).....))))...)).....)))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((...((((....]))))...))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..(((((((..(((.((......(((..((((((..(((((.(((.(((((.((((((((()))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..)).)))......((((..(.((((((...((.......))...))))))...).)).).).....((.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..))....(.(((((....))).)).)..>.))..))).)))))))[...(((((((...((((..((((((......(....).....)))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..)])))))(....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))..).)))))))). A. baumannii Ribosome-Eravacycline complex: E-site tRNA 70S; 23s ribosomal RNA 7m4y B 115 2.5 RF00001 URS00002D8B10_480119 34044590 0003735 0005840 480119 gcuggcgaccauagcaagagugaaccaccugaucccuucccgaacucagaagugaaaccucuuagcgcugaugguagugugggauuacccaugugagaguaagucaucgccagcu <<<<<<<<.....<<<<<<<.....<<<<<<...............>>>..>>>....>>>>>.>><<<.......<<<<<<<....>>>>>>>.......>>>..>>>>>>>>. ((((((((.....(((((((.....(((((((...(.....)...))))..)))....))))).))(((.......(((((((....))))))).......)))..)))))))). A. baumannii Ribosome-Eravacycline complex: E-site tRNA 70S; 5s ribosomal RNA 7m4y a 1528 2.5 RF00177,RF01959,RF01960 URS00023119FB_480119 34044590 0003735 0005840 480119 uaacugaagaguuugaucauggcucagauugaacgcuggcggcaggcuuaacacaugcaagucgagcgggggaagguagcuugcuaccggaccuagcggcggacgggugaguaaugcuuaggaaucugccuauuagugggggacaacaucucgaaagggaugcuaauaccgcauacguccuacgggagaaagcaggggaucuucggaccuugcgcuaauagaugagccuaagucggauuagcuaguuggugggguaaaggccuaccaaggcgacgaucuguagcgggucugagaggaugauccgccacacugggacugagacacggcccagacuccuacgggaggcagcaguggggaauauuggacaauggggggaacccugauccagccaugccgcgugugugaagaaggccuuaugguuguaaagcacuuuaagcgaggaggaggcuacucuaguuaauaccuagggauaguggacguuacucgcagaauaagcaccggcuaacucugugccagcagccncgguaauacagagggugcgagcguuaaucggauuuacugggcguaaagcgugcguaggcggcuuauuaagucggaugugaaauccccgagcuuaacuugggaauugcauucgauacuggugagcuagaguaugggagaggaugguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgauggcgaaggcagccaucuggccuaauacugacgcugagguacgaaagcauggggagcaaacaggauuagauacccugguaguccaugccguaaacgaugucuacuagccguuggggccuuugaggcuuuaguggcgcagcuaacgcgauaaguagaccgccuggggaguacggucgcaagacuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggccuugacauacuagaaacuuuucagagauggauuggugccuucgggaaccuagauacaggugcugcauggcugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuuuuccuuacuugccagcauuucggaugggaacuuuaaggauacugccagugacaaacuggaggaaggcggggacgacgucaagucaucaugncccuuacggccagggcuacacacgugcuacaauggucgguacaaaggguugcuacacagcgaugugaugcuaaucucaaaaagccgaucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucgcggaucagaaugccgcggugaauacguucccgggccuuguacacaccgnccgucacaccaugggaguuuguugcaccagaaguagcuagccuaacugcaaagagggcgguuaccacgguguggccgaugacuggggugaagucgnaacaagguagccguaggggnnccugcggcuggauc ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<<...<<<<<....>>>>>...>>>.>>>>>......<<.......<<<<<<<..<<...<<<<<<<<<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>>>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<<<<<<<<<<.......>>>>>>.>>>>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<<...>>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<...<..<<<<....>>>>..>...<<....>>...>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<<..<<<.....>>>>>.....>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<.<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>.>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((...((((((..))))))...))).)))))......(((......(((((((..((...(((((((((.((.....((((((....))))))......)).).....(((....)))....((((((..((....))))))))))))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(...(((((((((.......)))))).)))....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((((((...)))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((...(..(.((....)).)..)...((....))...)))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.((((((....((..(((.....))))).....))))))..(..((((.......)))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((.((((((((....((((((.((((..((....)).))))))))))...)))))))).)))..))).))))..).))...)..)..(((((((((....)))))))))}.... A. baumannii Ribosome-Eravacycline complex: E-site tRNA 70S; 16s Ribosomal RNA 7m4y v 77 2.5 RF00005 URS00002D670D_480119 34044590 0030533 0006412 480119 ggcuaugnagcucaguuggnuagagcaccgcacucauaaugcgggggucacaagnucaagucucgucauagccacca <<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<.<<.......>>.>>>>>>>>>.... (((((((..((((.........)))).(((((.......))))).....((.((.......)).))))))))).... A. baumannii Ribosome-Eravacycline complex: E-site tRNA 70S; tRNA-met 7m4z A 2730 2.92 RF02540,RF02541 URS000231197A_480119 34044590 0003735 0005840 480119 gucaaguaauuaagugcaugugguggaugccuuggcagucagaggcgaugaaagacgugauagccugcgaaaagcuccggggaggcggcaaauauccuuugauccggagaugucugaaugggggaacccaccuacuuuaagguagguauugcaacaugaauacauaguguugcaaggcgaacgaggggaagugaaacaucucaguacccuuaggaaaagaaaucaauugagauucccucaguagcggcgagcgaacggggaucagcccauuaaguuauguguguuuuaguggaacgcucugggaagugcgaacguagagggugauauucccguacacgaaagggcacacauaaugaugacgaguagggcgaggcacgugaaaccuugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccugugaggggagugaaauagauccugaaaccgcaugcauacaagcagugggagcaccuucguggugugacugcguaccuuuuguauaaugggucagcgacuuauauucaguagcgagguuaaccguauaggggagccguagagaaaucgagucuuaauagggcguuuaguugcuggguauagacccgaaaccaggcgaucuauccaugagcagguugaagguuggguaacacuaacuggaggaccgaacccacugucguugaaaagccaggggaugacuuguggauaggggugaaaggcuaaucaagccuggugauagcugguucuccccgaaagcuauuuagguagcgccucggacgaauaccauaggggguagagcacuguuucggcaccgaugcaaacuccgaauaccuaugaguacuauccgggagacagacugcgggugcuaacguccguagucaagaggaaaacaauccagaccgccagcuaaggccccaaaaucauaguuaagugggaaacgaugugggaaggcauagacagcuauagucgagucggccugcgcggaagauguaacggggcuaaaacuaugugccgaagcugcggauguauacuuuguauacgugguaggggagcguucuguaagccgaugaagguguguugagaagcaugcuggagguaucagaagugcgaaugcugacgugaguaacgacaaaacgggugaaaaacccguucgccgaaagaccaaggguuccaguccaacguuaaucggggcugggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaaaugguuaauauuccauuacuucuguguaaugcgaugagaggacggagaaggcuaaaucagccuggcguugguuguccaggugaaaggauguaggcauguaucuuaggcaaauccgggguacucuaugcugagaucugauagcaagcuguacuugugcagcgaagugguugaugccaugcuuccaggaaaagucucuaagcuucaguuacacaggaaucguacccgaaaccgacacagguggucaggucgaguagaccaaggcgcuugagagaacucugcugaaggaacuaggcaaaaugguaccguaacuucgggagaagguacgcuguuguuggugauggaacucgcuuccugagcugacgacagccgcagaaaccaggccgcugcaacuguuuauuaaaaacauagcacucugcaaacacgaaaguggacguauagggugugaugccugcccggugcuggaagguuaauugaugggguuagcguaagcgaagcucuugaucgaagccccaguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgaccugcacgaauggcauaaugauggcggcgcugucuccagcagaggcucagugaaaucgaaaucgcugugnagaugcaguguacccgcggcuagacggaaagaccccgunaaccuuuacugcagcuugacacugaacuuugauugagguucuaacucugucccgugauccgggacgaggaccgugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggaguacgaaggugcgcucagcguggucggaaaucacgcguagaguauaaaggcaaaagcgcgcuuaacugcgagacccacaagucgagcagguacgaaaguaggucuuagugauccggugguucuguauggaagggccaucgcucaacggauaaaagguacucugnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgnugucggcucaucucauccuggggcugaagcaggucccaaggguauggcnguucgccauuuaaagagguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucuaccgugggcgcuggaaauuugagaggaucugcuccuaguacgagaggaccagaguggacgaaccucugguguaccgguugugacgccagucgcaucgccggguagcuauguucggaagggauaaccgcugaaagcaucuaagcgggaagccuaccucaagauaagauuucccuaggacuuuauguccucuaaagagccguucgagacuaggacguugauagguuggauguggaagcauagugauaugugaagcugaccaauacuaauugcucgugaggcuugacu <<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<.)))......>>.....>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<......<<<<<<<<<<<<<<.<<<...<<<.<......>.>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>...........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..>>>......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<.....>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<.<........>.>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<....<<<<<<<<<......<<...<<<.<<<<..>>>>.>>>..>>.......>>>>>>.>>>...>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<.........<<..>>.....>>..>>>>>.>>...........)))......>>>>>>.>>>...>>>>>>><<<<<<<<...>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<...((((...>>>>>>....<<<<...<<<<.<<<<<<..<<.....>>.>>>>>>....>>>>...>>>>........<<<<<......>>>>>....>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<<<<<<<...<<<<.....>>>>...>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<<.<<....>>..>>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<.<<<<.[[......<<<<.[[<<<<..<<<<..<<<.<<<<<.<<<<<<<<..>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>...>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<.................>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))))>>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<<<<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>...>>>>..>..>>>>>>>. ((((((([.....((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(..]]]...]...)......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((..(..((.((((((((.((.(((...(((.(......).)))[[(...).(((.....]])))...)))...)).)))))))).))...)..)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((.....)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((.(.......<).))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).(((((((...((((((((((.....(((...(((.((((..)))).)))..)).).....)))))).))).).)))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{...(()).....)))..))))).))...........]]].)....))))))))))...)))))))((((((((...))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((...(((...(((....)))...)))...)))..(((((........)))))]]((((((((((.((...((((....((((..(((..((((((((((((...{{{.).))))))....(((....((((.(((((.(.((.....))).)))))....))))..[.))).....(..((((((....))))))...))))))...)))...))))(..).....))))...)).....)))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((...((((....]))))...))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..(((((((..(((.((......(((..((((((..(((((.(((.(((((.((((((.(()).))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..)).)))......((((..(.((((((...((.......))...))))))...).)).).).....((.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..))....(.(((((....))).)).)..>.))..))).)))))))[...(((((((...((((..((((((......(....).....)))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..)])))))(....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))..).)))))))). A. baumannii Ribosome-Eravacycline complex: hpf-bound 70S; 23s ribosomal RNA 7m4z B 115 2.92 RF00001 URS00002D8B10_480119 34044590 0003735 0005840 480119 gcuggcgaccauagcaagagugaaccaccugaucccuucccgaacucagaagugaaaccucuuagcgcugaugguagugugggauuacccaugugagaguaagucaucgccagcu <<<<<<<<.....<<<<<<<.....<<<<<<...............>>>..>>>....>>>>>.>><<<.......<<<<<<<....>>>>>>>.......>>>..>>>>>>>>. ((((((((.....(((((((.....((((((....(.....)....)))..)))....))))).))(((.......((.((((....)))).)).......)))..)))))))). A. baumannii Ribosome-Eravacycline complex: hpf-bound 70S; 5s ribosomal RNA 7m4z a 1528 2.92 RF00177,RF01959,RF01960 URS00023119FB_480119 34044590 0003735 0005840 480119 uaacugaagaguuugaucauggcucagauugaacgcuggcggcaggcuuaacacaugcaagucgagcgggggaagguagcuugcuaccggaccuagcggcggacgggugaguaaugcuuaggaaucugccuauuagugggggacaacaucucgaaagggaugcuaauaccgcauacguccuacgggagaaagcaggggaucuucggaccuugcgcuaauagaugagccuaagucggauuagcuaguuggugggguaaaggccuaccaaggcgacgaucuguagcgggucugagaggaugauccgccacacugggacugagacacggcccagacuccuacgggaggcagcaguggggaauauuggacaauggggggaacccugauccagccaugccgcgugugugaagaaggccuuaugguuguaaagcacuuuaagcgaggaggaggcuacucuaguuaauaccuagggauaguggacguuacucgcagaauaagcaccggcuaacucugugccagcagccncgguaauacagagggugcgagcguuaaucggauuuacugggcguaaagcgugcguaggcggcuuauuaagucggaugugaaauccccgagcuuaacuugggaauugcauucgauacuggugagcuagaguaugggagaggaugguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgauggcgaaggcagccaucuggccuaauacugacgcugagguacgaaagcauggggagcaaacaggauuagauacccugguaguccaugccguaaacgaugucuacuagccguuggggccuuugaggcuuuaguggcgcagcuaacgcgauaaguagaccgccuggggaguacggucgcaagacuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggccuugacauacuagaaacuuuucagagauggauuggugccuucgggaaccuagauacaggugcugcauggcugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuuuuccuuacuugccagcauuucggaugggaacuuuaaggauacugccagugacaaacuggaggaaggcggggacgacgucaagucaucaugncccuuacggccagggcuacacacgugcuacaauggucgguacaaaggguugcuacacagcgaugugaugcuaaucucaaaaagccgaucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucgcggaucagaaugccgcggugaauacguucccgggccuuguacacaccgnccgucacaccaugggaguuuguugcaccagaaguagcuagccuaacugcaaagagggcgguuaccacgguguggccgaugacuggggugaagucgnaacaagguagccguaggggnnccugcggcuggauc ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<<...<<<<<<..>>>>>>...>>>.>>>>>......<<.......<<<<<<<..<<...<<<<<<<<<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<.<.<<....>>>>>>>>>>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<<<<<<<<<<.......>>>>>>.>>>>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<<...>>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<...<..<<<<....>>>>..>...<<....>>...>>>>.>>.<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<<..<<<.....>>>>>.....>>>>>>.....<<<<<.....>>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<.<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>.>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((...((((((..))))))...))).)))))......(((......(((((((..((...(((((((((.((.....((((((....))))))......)).).....(((....)))....(((((...((....)).)))))))))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(..((((((((((.......)))))).))))...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((((((...)))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((...(..(.((....)).)..)...((....))...)))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.((((((....((..(((.....))))).....))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(.(..(((.((((((((....((((((.((((..((....)).))))))))))...)))))))).)))..).).))))..).))...)..)..(((((((((....)))))))))}.... A. baumannii Ribosome-Eravacycline complex: hpf-bound 70S; 16s Ribosomal RNA 7m50 e 12 2.31 URS000080DF9E_12881 34866603 12881 uuuuuuuuuuuu ............ ............ Crystallographic structure of a cubic crystal form of STMV grown from ammonium sulfate; RNA (5'-R(P*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*U))-3') 7m50 WW 10 2.31 URS000080DF9E_12881 34866603 12881 uuuuuuuuuu .......... .......... Crystallographic structure of a cubic crystal form of STMV grown from ammonium sulfate; RNA (5'-R(P*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*U))-3') 7m57 P 10 4.0 URS0002311A1B_12881 34866603 12881 aaaaaaaaaa .......... .......... Crystallographic structure of a primitive orthorhombic crystal form of STMV; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 7m57 Q 10 4.0 URS0002311A1B_12881 34866603 12881 aaaaaaaaaa .......... .......... Crystallographic structure of a primitive orthorhombic crystal form of STMV; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 7m57 R 10 4.0 URS0002311A1B_12881 34866603 12881 aaaaaaaaaa .......... .......... Crystallographic structure of a primitive orthorhombic crystal form of STMV; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 7m57 S 10 4.0 URS0002311A1B_12881 34866603 12881 aaaaaaaaaa .......... .......... Crystallographic structure of a primitive orthorhombic crystal form of STMV; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 7m57 T 10 4.0 URS0002311A1B_12881 34866603 12881 aaaaaaaaaa .......... .......... Crystallographic structure of a primitive orthorhombic crystal form of STMV; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 7m57 U 10 4.0 URS0002311A1B_12881 34866603 12881 aaaaaaaaaa .......... .......... Crystallographic structure of a primitive orthorhombic crystal form of STMV; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 7m57 V 10 4.0 URS0002311A1B_12881 34866603 12881 aaaaaaaaaa .......... .......... Crystallographic structure of a primitive orthorhombic crystal form of STMV; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 7m57 W 10 4.0 URS0002311A1B_12881 34866603 12881 aaaaaaaaaa .......... .......... Crystallographic structure of a primitive orthorhombic crystal form of STMV; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 7m57 X 10 4.0 URS0002311A1B_12881 34866603 12881 aaaaaaaaaa .......... .......... Crystallographic structure of a primitive orthorhombic crystal form of STMV; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 7m57 Y 10 4.0 URS0002311A1B_12881 34866603 12881 aaaaaaaaaa .......... .......... Crystallographic structure of a primitive orthorhombic crystal form of STMV; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 7m57 Z 10 4.0 URS0002311A1B_12881 34866603 12881 aaaaaaaaaa .......... .......... Crystallographic structure of a primitive orthorhombic crystal form of STMV; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 7m57 a 10 4.0 URS0002311A1B_12881 34866603 12881 aaaaaaaaaa .......... .......... Crystallographic structure of a primitive orthorhombic crystal form of STMV; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 7m57 b 10 4.0 URS0002311A1B_12881 34866603 12881 aaaaaaaaaa .......... .......... Crystallographic structure of a primitive orthorhombic crystal form of STMV; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 7m57 c 10 4.0 URS0002311A1B_12881 34866603 12881 aaaaaaaaaa .......... .......... Crystallographic structure of a primitive orthorhombic crystal form of STMV; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 7m57 d 10 4.0 URS0002311A1B_12881 34866603 12881 aaaaaaaaaa .......... .......... Crystallographic structure of a primitive orthorhombic crystal form of STMV; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 7m57 e 10 4.0 URS0001C1D8A6_12881 34866603 12881 uuuuuuuuuu .......... .......... Crystallographic structure of a primitive orthorhombic crystal form of STMV; RNA (27-mer) 7m57 f 10 4.0 URS0001C1D8A6_12881 34866603 12881 uuuuuuuuuu .......... .......... Crystallographic structure of a primitive orthorhombic crystal form of STMV; RNA (27-mer) 7m57 g 10 4.0 URS0001C1D8A6_12881 34866603 12881 uuuuuuuuuu .......... .......... Crystallographic structure of a primitive orthorhombic crystal form of STMV; RNA (27-mer) 7m57 h 10 4.0 URS0001C1D8A6_12881 34866603 12881 uuuuuuuuuu .......... .......... Crystallographic structure of a primitive orthorhombic crystal form of STMV; RNA (27-mer) 7m57 i 10 4.0 URS0001C1D8A6_12881 34866603 12881 uuuuuuuuuu .......... .......... Crystallographic structure of a primitive orthorhombic crystal form of STMV; RNA (27-mer) 7m57 j 10 4.0 URS0001C1D8A6_12881 34866603 12881 uuuuuuuuuu .......... .......... Crystallographic structure of a primitive orthorhombic crystal form of STMV; RNA (27-mer) 7m57 k 10 4.0 URS0001C1D8A6_12881 34866603 12881 uuuuuuuuuu .......... .......... Crystallographic structure of a primitive orthorhombic crystal form of STMV; RNA (27-mer) 7m57 l 10 4.0 URS0001C1D8A6_12881 34866603 12881 uuuuuuuuuu .......... .......... Crystallographic structure of a primitive orthorhombic crystal form of STMV; RNA (27-mer) 7m57 m 10 4.0 URS0001C1D8A6_12881 34866603 12881 uuuuuuuuuu .......... .......... Crystallographic structure of a primitive orthorhombic crystal form of STMV; RNA (27-mer) 7m57 n 10 4.0 URS0001C1D8A6_12881 34866603 12881 uuuuuuuuuu .......... .......... Crystallographic structure of a primitive orthorhombic crystal form of STMV; RNA (27-mer) 7m57 o 10 4.0 URS0001C1D8A6_12881 34866603 12881 uuuuuuuuuu .......... .......... Crystallographic structure of a primitive orthorhombic crystal form of STMV; RNA (27-mer) 7m57 p 10 4.0 URS0001C1D8A6_12881 34866603 12881 uuuuuuuuuu .......... .......... Crystallographic structure of a primitive orthorhombic crystal form of STMV; RNA (27-mer) 7m57 q 10 4.0 URS0001C1D8A6_12881 34866603 12881 uuuuuuuuuu .......... .......... Crystallographic structure of a primitive orthorhombic crystal form of STMV; RNA (27-mer) 7m57 r 10 4.0 URS0001C1D8A6_12881 34866603 12881 uuuuuuuuuu .......... .......... Crystallographic structure of a primitive orthorhombic crystal form of STMV; RNA (27-mer) 7m57 s 10 4.0 URS0001C1D8A6_12881 34866603 12881 uuuuuuuuuu .......... .......... Crystallographic structure of a primitive orthorhombic crystal form of STMV; RNA (27-mer) 7m57 7 22 4.0 URS0001C1D8A6_12881 34866603 12881 uuuuuuuuuuuuuuuuuuuuuu ...................... ...................... Crystallographic structure of a primitive orthorhombic crystal form of STMV; RNA (27-mer) 7m57 QQ 10 4.0 URS0002311A1B_12881 34866603 12881 aaaaaaaaaa .......... .......... Crystallographic structure of a primitive orthorhombic crystal form of STMV; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 7m57 RR 10 4.0 URS0002311A1B_12881 34866603 12881 aaaaaaaaaa .......... .......... Crystallographic structure of a primitive orthorhombic crystal form of STMV; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 7m57 SS 10 4.0 URS0002311A1B_12881 34866603 12881 aaaaaaaaaa .......... .......... Crystallographic structure of a primitive orthorhombic crystal form of STMV; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 7m57 TT 10 4.0 URS0002311A1B_12881 34866603 12881 aaaaaaaaaa .......... .......... Crystallographic structure of a primitive orthorhombic crystal form of STMV; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 7m57 UU 10 4.0 URS0002311A1B_12881 34866603 12881 aaaaaaaaaa .......... .......... Crystallographic structure of a primitive orthorhombic crystal form of STMV; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 7m57 VV 10 4.0 URS0002311A1B_12881 34866603 12881 aaaaaaaaaa .......... .......... Crystallographic structure of a primitive orthorhombic crystal form of STMV; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 7m57 WW 10 4.0 URS0002311A1B_12881 34866603 12881 aaaaaaaaaa .......... .......... Crystallographic structure of a primitive orthorhombic crystal form of STMV; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 7m57 YY 10 4.0 URS0002311A1B_12881 34866603 12881 aaaaaaaaaa .......... .......... Crystallographic structure of a primitive orthorhombic crystal form of STMV; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 7m57 ZZ 10 4.0 URS0002311A1B_12881 34866603 12881 aaaaaaaaaa .......... .......... Crystallographic structure of a primitive orthorhombic crystal form of STMV; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 7m57 bb 10 4.0 URS0002311A1B_12881 34866603 12881 aaaaaaaaaa .......... .......... Crystallographic structure of a primitive orthorhombic crystal form of STMV; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 7m57 cc 10 4.0 URS0002311A1B_12881 34866603 12881 aaaaaaaaaa .......... .......... Crystallographic structure of a primitive orthorhombic crystal form of STMV; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 7m57 dd 10 4.0 URS0002311A1B_12881 34866603 12881 aaaaaaaaaa .......... .......... Crystallographic structure of a primitive orthorhombic crystal form of STMV; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 7m57 ee 10 4.0 URS0002311A1B_12881 34866603 12881 aaaaaaaaaa .......... .......... Crystallographic structure of a primitive orthorhombic crystal form of STMV; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 7m57 ff 10 4.0 URS0002311A1B_12881 34866603 12881 aaaaaaaaaa .......... .......... Crystallographic structure of a primitive orthorhombic crystal form of STMV; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 7m57 gg 10 4.0 URS0002311A1B_12881 34866603 12881 aaaaaaaaaa .......... .......... Crystallographic structure of a primitive orthorhombic crystal form of STMV; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') 7m57 hh 10 4.0 URS0001C1D8A6_12881 34866603 12881 uuuuuuuuuu .......... .......... Crystallographic structure of a primitive orthorhombic crystal form of STMV; RNA (27-mer) 7m57 ii 10 4.0 URS0001C1D8A6_12881 34866603 12881 uuuuuuuuuu .......... .......... Crystallographic structure of a primitive orthorhombic crystal form of STMV; RNA (27-mer) 7m57 jj 10 4.0 URS0001C1D8A6_12881 34866603 12881 uuuuuuuuuu .......... .......... Crystallographic structure of a primitive orthorhombic crystal form of STMV; RNA (27-mer) 7m57 kk 10 4.0 URS0001C1D8A6_12881 34866603 12881 uuuuuuuuuu .......... .......... Crystallographic structure of a primitive orthorhombic crystal form of STMV; RNA (27-mer) 7m57 ll 10 4.0 URS0001C1D8A6_12881 34866603 12881 uuuuuuuuuu .......... .......... Crystallographic structure of a primitive orthorhombic crystal form of STMV; RNA (27-mer) 7m57 mm 10 4.0 URS0001C1D8A6_12881 34866603 12881 uuuuuuuuuu .......... .......... Crystallographic structure of a primitive orthorhombic crystal form of STMV; RNA (27-mer) 7m57 nn 10 4.0 URS0001C1D8A6_12881 34866603 12881 uuuuuuuuuu .......... .......... Crystallographic structure of a primitive orthorhombic crystal form of STMV; RNA (27-mer) 7m57 oo 10 4.0 URS0001C1D8A6_12881 34866603 12881 uuuuuuuuuu .......... .......... Crystallographic structure of a primitive orthorhombic crystal form of STMV; RNA (27-mer) 7m57 pp 10 4.0 URS0001C1D8A6_12881 34866603 12881 uuuuuuuuuu .......... .......... Crystallographic structure of a primitive orthorhombic crystal form of STMV; RNA (27-mer) 7m57 qq 10 4.0 URS0001C1D8A6_12881 34866603 12881 uuuuuuuuuu .......... .......... Crystallographic structure of a primitive orthorhombic crystal form of STMV; RNA (27-mer) 7m57 rr 10 4.0 URS0001C1D8A6_12881 34866603 12881 uuuuuuuuuu .......... .......... Crystallographic structure of a primitive orthorhombic crystal form of STMV; RNA (27-mer) 7m57 ss 10 4.0 URS0001C1D8A6_12881 34866603 12881 uuuuuuuuuu .......... .......... Crystallographic structure of a primitive orthorhombic crystal form of STMV; RNA (27-mer) 7m57 tt 10 4.0 URS0001C1D8A6_12881 34866603 12881 uuuuuuuuuu .......... .......... Crystallographic structure of a primitive orthorhombic crystal form of STMV; RNA (27-mer) 7m57 uu 10 4.0 URS0001C1D8A6_12881 34866603 12881 uuuuuuuuuu .......... .......... Crystallographic structure of a primitive orthorhombic crystal form of STMV; RNA (27-mer) 7m57 vv 10 4.0 URS0001C1D8A6_12881 34866603 12881 uuuuuuuuuu .......... .......... Crystallographic structure of a primitive orthorhombic crystal form of STMV; RNA (27-mer) 7m5d 1 2903 2.8 RF02541 URS00021ED9BC_562 0003735 0005840 562 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<<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<<.....>>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<.<.<<<...<<<....>>>...>>>..>>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.......<<<<<<.<<....>>..>>>>>>.......>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<.<..<<<............<<<<<...<.......<<<<<<<<....>>>>>>>>....>.............>>>>>...>>>..>.>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((.((.(.....).))..))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..)))........(((......)))..)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((..((....))..)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((.((...(...(..........(..(....(........(..(((....)))..).....)..............)..).)....)..)).)))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(.(((((....))).)).)....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Cryo-EM structure of a non-rotated E.coli 70S ribosome in complex with RF3-GTP, RF1 and P-tRNA (state I); 23S ribosomal RNA 7m5d 2 1534 2.8 RF00177,RF01959,RF02542,RF01960 URS000081169C_562 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<......>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.<...>.>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<....>>>>>>..............>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((........))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....(((.((((.......)))).))).....)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((....(.(((....))).)...............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Cryo-EM structure of a non-rotated E.coli 70S ribosome in complex with RF3-GTP, RF1 and P-tRNA (state I); 16S ribosomal RNA 7m5d 3 120 2.8 RF00001 URS0000049E57_562 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Cryo-EM structure of a non-rotated E.coli 70S ribosome in complex with RF3-GTP, RF1 and P-tRNA (state I); 5S ribosomal RNA 7m5d 4 15 2.8 562 uucuucuaaaaaaaa ............... ............... Cryo-EM structure of a non-rotated E.coli 70S ribosome in complex with RF3-GTP, RF1 and P-tRNA (state I); mRNA 7m5d 5 76 2.8 RF00005 URS0000EEACF3_562 0030533 0006412 562 gcggggungagcagccuggnagcucgucgggnugaaaacccgaagaucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(.(((..]....))).)))))))..... Cryo-EM structure of a non-rotated E.coli 70S ribosome in complex with RF3-GTP, RF1 and P-tRNA (state I); P-tRNA 7md7 1A 2872 2.8 RF02540,RF02541,RF00002 URS00001698E8_300852 33916420 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>....<<<<<.....<......>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<......>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> 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Crystal structure of the Thermus thermophilus 70S ribosome in complex with triphenylphosphonium analog of chloramphenicol CAM-C4-TPP and protein Y (YfiA) at 2.80A resolution; 23S Ribosomal RNA 7md7 1B 120 2.8 RF00001 URS000080DEE8_300852 33916420 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>. .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the Thermus thermophilus 70S ribosome in complex with triphenylphosphonium analog of chloramphenicol CAM-C4-TPP and protein Y (YfiA) at 2.80A resolution; 5S Ribosomal RNA 7md7 1a 1500 2.8 RF00177,RF01959,RF01960 URS000080DFED_300852 33916420 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<.<......>.>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((..)))))))).)))))......(((......((((((((..((...((((((..(((((....((((((....)))))).....)))))....((.(.(((((....))))).).))...((((...))))..))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......(.((((.....)))).)....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((...(((((((....)))))))...((((....))))...)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the Thermus thermophilus 70S ribosome in complex with triphenylphosphonium analog of chloramphenicol CAM-C4-TPP and protein Y (YfiA) at 2.80A resolution; 16S Ribosomal RNA 7md7 2A 2867 2.8 RF02540,RF02541,RF00002 URS00001698E8_300852 33916420 0003735 0005840 300852 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<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>....<<<<<.....<......>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<.<.<<<<<<......>>>>.>>>..>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<.......>>>....>>......................>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<..>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<.......<<<<<<......>>>>>>....>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> 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Crystal structure of the Thermus thermophilus 70S ribosome in complex with triphenylphosphonium analog of chloramphenicol CAM-C4-TPP and protein Y (YfiA) at 2.80A resolution; 23S Ribosomal RNA 7md7 2B 120 2.8 RF00001 URS000080DEE8_300852 33916420 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the Thermus thermophilus 70S ribosome in complex with triphenylphosphonium analog of chloramphenicol CAM-C4-TPP and protein Y (YfiA) at 2.80A resolution; 5S Ribosomal RNA 7md7 2a 1504 2.8 RF00177,RF01959,RF01960 URS000080DFED_300852 33916420 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>.....<......>....>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((((((....))))))).(..(((....)))..).)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the Thermus thermophilus 70S ribosome in complex with triphenylphosphonium analog of chloramphenicol CAM-C4-TPP and protein Y (YfiA) at 2.80A resolution; 16S Ribosomal RNA 7mdz 5 3541 3.2 RF02540,RF02543 URS000197CF67_9986 34403584 0003735 0005840 9986 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggaaauguggcguacggaagacccacuccccggcgccggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcgcgguccggccgugccggcggggcggaucucccgcucccgucggcgggggaccgccccccggccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggccccggcggggaagguggcccgggggccccggguguuacagccccgccccggcagcagcagcucgccgaaucccggggccgagggagcgagacccgugcgccgcgcucuccccccucgggggggccgggccaccccucccacggcgcgaccgcuggggcggacuguccagugcgccccgggcgggucgcgccgucgggcccggggggccacgcgucccccgcgagcgcacggggucggcggcgaugucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcuacgaaagccgccguggcgcaaugaaggugaaggccggcggcgcgccgccggccgaggugggaucccgaggccuuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcgaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccaaaguuucccucaggauagcuggcgcucuccgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcugguguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggaugguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgcuggcagucggcagagcgagaaagagaguggcgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucagccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcuggcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagauuuuuucacugacccggugaggcgggggggcgagccgggcucucgcuucuggcgccaagcgcccggccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauagcgccggagccucgguuggccucggauagccggucccccgccgggguccggugcggagagcccuucgucccgggaaacggggcggccggaaagggggccgcccucucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcugcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..[[[...<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>...<<<<<<<<<....<<<<<<<<..<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>...>>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<......>>>..................................<<<<<<<<..<<<.<....<<<<<<<<.<<<.....<<<<<<<<<<....<<<<<<<.<<<<..<<<<<<<.<<<<<<<<<......>>>>>>>>>>>>>>>>.>>>>>>>>...>>>.>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<.<<<<<<<<<<<<<<<...<<..<<<..<<<<<<<......<<<<<<<<.>>>>>>>>.......>>>>>>>..>>>.........>>>>>>..>>>>>>>>>>>.....<<.......>>.........<...<<<<<<..>>>>>>...<.<<..<<<.<<<<<<<<<<<.<<<<<<<<<<<.<<<<..>>>>.>>>>>>>.>>.>>.>>>>>>>>.>>>...>>>>>.>................>.........>>.>>>>>....>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<.....>>>>.....>>>...<<....>>...<<<<<<<<<<..>>>>>>>>>>..<<<<<...<<<..<<<....[[.[[.>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<...<<<.<<<<<<<<<...<<<....<<<....<<<..<<<<<<.........>>>>>>>>>....>>>..>.>>...>>>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<......<..........<<<.<<<<<<<<<<.......<<<<<.<<.....................>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>....>>>>>..>>>...>>>>>>><<<<<<.<<<....................]].]].............>>>>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<<<<<...>>>>>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<...<<<<<<<....>>>>>>>...<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..{{{..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<.<<<<<<<<<<<.>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<<.<<<<<<<<..>>>>>>>>...<<<<<.....<<<<..<<.<.<<<>>.>>.>>..............<<<<<<<<<..>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>><<<<....>>>>>>)))]......((((((..(((..>>>>>>.)))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]].....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<}}}.>>>>>..>>.>>...>>>>...>>>><<<<....<<<<<...........>>>>>....>>>>.>>>...>.>>>>>>.<<<<<<<..<<<<....<<<........<<<<<..<<<<...>>>>.>>>>>.......>>>...<<<..<<<<....<<<<<<<<<........>>>>>>.>>>...>>>>..>>>..............>>>>..>.>>>>>>.<<<<<.<.............>....<<.<<<<<<<.<<.....<<<<.<..<<<<<.>>>>>..>>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..(((((((((((.....)))))).))))....))))....(((((((((....(((((.((..((((((((..({((((......)))))....[[(...).(((....}]])))...).)))))))...)).)))))...)))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....((((((((((.(..(((((((.((((..(((((((.((.((.((........)).)).))))))))).))))))))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((..(((((((......((((((((.)))))))).......)))))))..))).........))))))..))))))))))).....((.....{.)).........(.(.((((((()))))))...(.((..(((.(((((((((((..((.(((((((.((((..)))).)))))).).).)..)))))))).)))...)))).))............[.).)........))).)))))...)))))...)))))))).<((((........))))((((((....(((((((((((((..(((..(((((.....))))..)..)))...((....))...(((((.((((())))).)))))..(((((...(((..(((]...[..[[[)))..)))....))))).(((((((((.((((......))))))))))).))....)))))))))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)<)))...(((..((.((.......B)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((...(((.((((((((....(((....(((..(.(((..(((.(..(.....)..).)))))).)..)))..)).)....))))))...(((((((((.(......))))))))))....))))))))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.....A.(((((...................................(........)...)))))...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((........}.........].]]..].............)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...((..(.(((....))).....)....((.((((.((((...)))).))))))......))....))...(((((........)))))]]((((....(((((.....(((((....)))))....((((....)))...(...((((((...(((((((((((((((((((((((...{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((.)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..(.((((.(...((.....((((....)))).....)).)))))...))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.(((((((((.(((((((.().)))))))...(((((.....((((..((.(..(())..).))..............(((((.(((()))).)))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..b.))..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}..)))))..)).))...))))...)))).((((...((((.....a.......))))...))))..)))...).)))))).(((((.(..((((....(((.........((((...((((.))))..))))........)))...(((..(((.....(((..((((........))))...)))....)))..)))..............))))..)..))))).(((((.(..(.......)..)....((.(((((((.((.....((((.(..(((((.)))))..)))))....))....)))).))).))..))))).. 80S rabbit ribosome stalled with benzamide-CHX; 28S rRNA 7mdz 7 119 3.2 RF00001 URS000002B0D5_9986 34403584 0003735 0005840 9986 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcu <<<<<<<<<....<<<<<<<<.....<<<<<<............>>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))). 80S rabbit ribosome stalled with benzamide-CHX; 5S rRNA 7mdz 8 151 3.2 RF00002 URS00004B2C76_9986 34403584 0003735 0005840 9986 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcagguugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<.<<.....>>>.....(.<<<......>>........>>>..)...>>>....<<<..>>><<<<<<<<.......>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]]........)))..)...)))....((....))((((((((.......)))))))).................... 80S rabbit ribosome stalled with benzamide-CHX; 5.8S rRNA 7mdz 2 76 3.2 RF00005 URS00005AA258_9986 34403584 0030533 0006412 9986 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((........)))).(((((.......))))).....((.((.......)).))))))))).... 80S rabbit ribosome stalled with benzamide-CHX; P-site tRNA 7mdz 9 1697 3.2 RF01960,RF01959,RF00177 URS0000704D22_9986 34403584 0003735 0005840 9986 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucgacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgcccggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcggccguccccugcucggcgccggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgaccccggucggcguaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggugcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<..<.....<<<.<....<<....<<<<<........<<.....<<.<<.......>>.>>......>>.........<<<<...<<<<<<....>>>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<<.>>>>>>>>.>>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>>>>.<<.<<<..........>>>.>>.<.<<<..>>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....<<<<<<<<<.<<<....>>>..>>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.......<<<.<<<..>>>.>>><<<<<<<..<..>.>>>>.>>>.<<<<<<.<.......<<...<.......>.<<<<.>>>>...>>......>.>>>..>>>..........<<.<<<<<<.................>>>>>>.>>............<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<........<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<..>>>>.>>>>>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.....>.>>>>>......>>>>.>>>.....<<.<<<................<<<.<<<<....>>>>.>>>..............>>>.>>............<<<<<..........>>>>>...........>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<.<<<<<<<<<..>>>>>>>>>...>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))((..((((((...(.((..((.....(((.(((..(.....((....((..........))...))[.)......(((.......(((.(.(..((....(((.....((...((.....((.(((.....))).))......))......)).((((...(((((......)))))...))))((..(((((...(......)..)))))......)).(.(((..((((.)))).))))...)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).).....(((((((((..((....))...)))))).)))....(.((..(...........)..))......)..((((([[......((((.....((..]])).......)))).)))))..))))))..))..[......(.([[...(.(.((...(((.......(((..((()))..)))((((((..(....).))).))).((((((.(.......((..((.......)).(((.)))....))......).)))..)))........(.((.((((((.................)))))).)).).........(((..((..(...((((..((..((((((((...((........))......))))))))..)).......((....))...))))..)..))...))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.(((((....))))))))))).)..)))...((..]]))...))...].))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((..(((((......((........))..........(((((.(....(.(((........((..((........))..))......))).)...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((...(...((((..((((((((((((..)))).))))))))..))))..).....(((((.....)))))........)))....))).))).....).))))).....).)))))...)).)))..))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....((.(((((.......))))).))......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..((((.((...((((((.(((.((((..)))).)))..).)))))...)).))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}........ 80S rabbit ribosome stalled with benzamide-CHX; 18S rRNA 7mdz 6 10 3.2 34403584 32630 auguucguua .......... .......... 80S rabbit ribosome stalled with benzamide-CHX; mRNA 7mpi B5 1781 3.05 RF01960,RF01959,RF00177 URS00023358CA_4932 35489333 0003735 0005840 4932 uaucugguugauccugccaguagucaunugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucnuuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauncaaggnaggcagcaggcgcgcnaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggnacaauuggagggcaagucugnugccagcagccgcggnaauuccagcuccaauagcguauauuaaaguuguugcaguunaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauungcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagancgaaaguuaggggaucgaagaugaucagauacngucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaangcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacncaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuuguggguggngnugcauggcnguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacangucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacnagnaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgnccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuucnguaggugnnccugcggaaggaucau ...<<<<<.{.((((>>>>><<<<.<<<<<<...<.<...<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<..<<..<<....<<<..................<.....<<.<<.......>>.>>......>.........<<<<<............>>>>><...<<<<<<.........((.................<........>>>>>>>.....>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<<..>>>.>...>>>>>>.........<<<....<<<.....>>>..>>>..>....>.>.....<<<..<..................>...>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>>.........<<<[[.....<.<<...<<<.<<....<<<<<<.<<.<..............>.>>.>>>>>>......<<<<...............................>>>>.....<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........<...................))...............>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..]]>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..)))).}<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<.<<<<<..>>>>>.>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>......<....<<<<<<..........>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<.........................>.>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>....... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...))[))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((............)))))(.(.((((((........{.{...(........).....(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)....).).....((...(.....(......).....)....))......(.(.(...........))..).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..[......((([[...(.(.((...(((.((....((((((.((.(......()......).)).))))))......((((.............(.....)...........)))).....(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(......(..(.........}.}.....)..).....).....))...(((.(((.((...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)).)))..))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(((.((((.((..........)))))).)))..)))...((..]]))...))...].))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((........((.(((........))).))......)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..(((...(((((..(.((((..)))).)....)))))...))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((.(((..........))).))....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(.(((((.((.(((..(.((..(...(((((...(....................)...)))))...)..)).)..))).)).))))))..)).))))...).))...)..)..(((((((((....)))))))))}...... Stm1 bound vacant 80S structure isolated from cbf5-D95A; 18S rRNA 7mpi A1 3137 3.05 RF02540,RF02543 URS00023358E2_4932 35489333 0003735 0005840 4932 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugnaacnnggaccaaggagunuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccnanagauggugancuaugccugaauagggugaagccagaggaaacucugguggaggcucguancgguucugncgugcaaaucgaucgucgaaunuggguauagnggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcngaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaunuuggugguagunncaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaanguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauunaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugccnagugcucugaaugucaaagugangaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagcnannugccucnucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugunccuaucuacnaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcungacncuaguuugacauugugaagagacauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcugnggcggcacaucugunaaacgnuaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauunucagngugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuanangugccagaaaaguuaccacagngauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuungaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggaunnuucacccacuaauagggaacgugngnuggguuuagancgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..<<<...........<<.<<<<<<...>>>>>>.>>.............<<<<<<.<<<<.<<<.<<<.<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>...>>>>>>......>>>>>>>>>>........<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<......<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<........>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<...<<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>>.<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<.................>>>....>>>..>>.>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.........<<<.............................<........>...>>>.....>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>>..<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<............>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<......<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..[[[..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>............>>.>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<.....<..>......>>>>><<.<<<<<<<<<<......>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.....<<.....<<<<....>>>>.....>>..>>>>..>>>>><<<<<.........>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<..<<<<<.............>>>>>...<<<<<.....<<<<..<<<..........>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))......<<<<<<<..<<<<.))))))>>>>>>>>>>>.........>>>>..>>>>>>.......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<<...<<<<<<<<<<]]].>>>>>..>>>>>..>>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((..(((.((..((((.(((((((...({((((......)))))[[(...).(((....}]])))....)))))))...)))).))......))).))))))...)....(((((((........)))))))......((((..[[[[[[))))...)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((......(((..........))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))).((((((......(((....)))..((((((((((....((.(((((((.....(((....(((..(.(((.................))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(.(((........(.........)......(...(........).).))).)...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...((((((...((.....)).))))))....[[(((.((...((....(((....))).........((.(.(.....)..).)).....))....))...(((((........)))))]]((((..(((((.....((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))....(((((....(((((.....(((.....))).....))))).....))))).....(((((((......))))))))))).).))))))).))))(...)....))))))...)).......)).))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((.(.(...)).))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(.(.(((..((((((.(...((.....(((......))).....)).)))))..)))))(.(.............).)........((..........(((((.......)))))..)..)....).)....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.(((.((..(((((.((((((((..(((((.............)))))....((((.....((((...((..........))............>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).((......)).))]]].].....((((((..((((.]]]]]]))))))))))....)}....)).)..)))))).......(....(..(((((...((.......))...)))))....)....)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((.(......(....).....).))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Stm1 bound vacant 80S structure isolated from cbf5-D95A; 25S rRNA 7mpi A3 121 3.05 RF00001 URS000055688D_4932 35489333 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<<............>>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....(((.((...(....)...))..)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Stm1 bound vacant 80S structure isolated from cbf5-D95A; 5s rRNA 7mpi A4 158 3.05 RF00002 URS00001BF64E_4932 35489333 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Stm1 bound vacant 80S structure isolated from cbf5-D95A; 5.8 S rRNA 7mpj B5 1781 2.7 RF01960,RF01959,RF00177 URS00023358CB_4932 35489333 0003735 0005840 4932 uaucugguugauccugccaguagucaunugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucnuuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauncaaggnaggcagcaggcgcgcnaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggnacaauuggagggcaagucugnugccagcagccgcggnaauuccagcuccaauagcguauauuaaaguuguugcaguunaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauungcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagancgaaaguuaggggaucgaagaugaucagauacngucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaangcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacncaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuuguggguggngnugcauggcnguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacangucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacnagnaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgnccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuucnguaggugnnccugcggaaggaucau ...<<<<<.{.((((>>>>><<<<.<<<<<<...<.<...<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<..<<..<<....<<<..................<.....<<.<<<.....>>>.>>......>.........<<<<<............>>>>><...<<<<<<.........((.................<<......>>>>>>>>.....>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>..>>>..>....>.>.....<<<..<..................>...>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>>.........<<<[[.....<.<<...<<<.<<....<<<<<<.<<.<..............>.>>.>>>>>>......<<<<...............................>>>>.....<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........<<..................))..............>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>......<<<....>>>..>>>>..>.>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..]]>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..)))).}<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<.<<<<<..>>>>>.>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>......<....<<<<<<..........>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<.........................>.>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>....... ...((((..[.[[[..))))((((.((((((...(.(....(.....(((.(((..((....((....((..........))...)){))......(((.......(((...(..((....(((..................((....((.(((.....))).)).....)).........(((((............)))))(.(.(((.((........[[[...(........).....(......).)).))).)...).(.((((..((((..).))).)))))...)))...)))...))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).)))))......).).....((...(.....(......).....)....))......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(.(.((....((((((.((.(......()......).)).))))))......((((.............(.....)...........)))).....(((((.((........(..((.......)).(((.....)))....).......)).))..))).........(......(..(.........]]].....)..).....).....))...(((.(((.((...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)).)))..))..)).)...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.((..........))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((.......(........)...........(((((.(....(((((........((.(((........))).))......)))))...((.(((...(.((((((....((..(((((....)))..(.((......)))...))..))....((((..((..(((...(((((.((.((((..)))).))...)))))...))).))..(.((((((.....))))))....)...))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((.(((..........))).))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...(((((...(....................)...)))))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>...... Stm1 bound vacant 80S structure isolated from wild-type; 18S rRNA 7mpj A1 3137 2.7 RF02540,RF02543 URS00023358EB_4932 35489333 0003735 0005840 4932 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........................<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..<<<...........<<.<<<<<<...>>>>>>.>>.............<<<<<<.<<<<..<<.<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>.......>>>>>>>>>>........<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<.<....<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<........>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<...<<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>>.<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<.................>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<......<..........<<<.<<<<<<<<<<.........<<<.............................<........>...>>>.....>>>>>>>>>>>>>..........))).>....>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>>..<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>.........<<<............>>>.....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<<....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..[[[..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>.........>>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<...............>>>>><<.<<<<<<<<<........>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.....<<.....<<<<....>>>>.....>>..>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<..<<<<<.............>>>>>...<<<<<.....<<<<..<<<..........>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))......<<<<<<<..<<<<.))))))>>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<<]]].>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((..(((.((..(((..(((((((...({((((......)))))[[(...).(((....}]])))....)))))))....))).))......))).))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((......(((..........))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))).((((((......(((....)))..(((.((((((....((.(.(((.(......((.....((..(.(((.................))).)..))...)).......).)))...((((.((((.(......))))).))))......)))..)))))).).))..((((.((.((.....)).)).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(.(((........(.........)......(...(........).).))).)...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....))).........((...(.....)....).)....))....))...(((((........)))))]]((((..(((.(((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))....(((((....(((((.....(((.....))).....))))).....))))).....(((((((......))))))))))).).))))))).))))(...)....))))))...))....)))...))).)))).)))..)).....((......)).)))).((((.....))))..))))..(.(......((((((..((..(....(.......(((((....(.{..).....)))))((.((((((((...(...)..))..)))))).))(...).......(((((((.(.].((.........))...(((((((....((((.....))))......))))))).}.(.(.(((..((((((.(...((.....(((......))).....)).)))))..)))))(.(.............).)........((..........(((((.......)))))..)..)....).)....)..))))))).)..)))..))))))...).)))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.(((((...(((((.((((((((..(((((.............)))))....((((.....((((...((..........))............>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...(((...(((....{..)))...))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}.....)))..)))))).......(....(.((((((...((.......))...))))))...)....)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).)......((((((....))).)))...>.))..))).)))))....((((((((..((((.(.(((.(......(....).....).))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((.(.(..(((......)))..).).))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(((.((..)..).)))..)))))...)))....)))).)))))).))))).. Stm1 bound vacant 80S structure isolated from wild-type; 25S rRNA 7mpj A3 121 2.7 RF00001 URS000055688D_4932 35489333 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<<............>>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Stm1 bound vacant 80S structure isolated from wild-type; 5S rRNA 7mpj A4 158 2.7 RF00002 URS00001BF64E_4932 35489333 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Stm1 bound vacant 80S structure isolated from wild-type; 5.8S rRNA 7mq8 L0 242 3.6 RF00957 URS0002311998_9606 34516797 0035195 0016442 9606 gaucgauguggugacgucgugcucucccgggccggguccgcggaccccggcccgaccucgcgcgggguccucugacgcggcagacagcccucgcugucgccgacuugcgggcggccccccuccgcggcggugggggugccgucccgccggcccgugcgucggcuccgggcccuugcggugcuccuggagcgcuccggguugcaggugcccgaggccgaugagaaaagccuucucuagcgauc ...................<<.<<....<<<<<<<<<<<<>>>>>>>.>>>>><<<<<<<..>>>>>>>....>>>>.<<<<<......>>.>>><<<<.>>>>...<<<<<<<<<<<<<.<<<...>>>.>>>>>.>>>>>.>>>..<<<<<<..>>..>>>>...................................................<<.>>...................... ..................(((.((....(((((((((((())))))).)))))(((((((())))))))....)))))(((((......)).)))((((.))))..((((.(((((((((.(((...))).))))).)))).).))).((((((()))..))))...................................................(...)...................... Cryo-EM structure of the human SSU processome, state pre-A1; 5'ETS rRNA 7mq8 L1 1301 3.6 RF01960,RF01959,RF00177 URS0000704D22_9606 34516797 0003735 0005840 9606 accugguugauccugccaguagcauaugcuugucucaaaaagccaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucgcuccuuacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccggggggaugcgugcauuuaucagaucaaaaccaacccgccccucgggcgggcgccggcggcuuuggcuagauaaccucgggccgaucgcacgccccccguggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugagggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguagcuccaauagcguauauuaaaagcucguaguuggaucauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccagaguaugguugugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccguggguuggugcauggccguucguugguggagcgauuugguuaauuccgauaacgaacgagacucuggcaugcuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccguccgggcgcgcgcuacacugacuggcucagcguguaaccccauucguaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggucggcccacggcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagguuuccguaggugaaccugcggaa ....................<<.<<<<<<...<.<<.....<<<..<<....<<....<<..........>>...>>.>>........<.......<<<.<....<<....<<<................<<.....<<.<<.......>>.>>......>>.........<<<<...<<<<..>>>>...>>>><<..<<<<<.....<<..<...<<..<<<<<..>>.>>>....>>.>..>>......>>>>>......>>...<<<<.<<<<......>>>>>>>>....>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>....<<<<<<.......>>>>>>...>.<<.<<<<........>>>>.>>.<.<<<..>>>.>..>>>........<<<<....<<<.....>>>..>>>>.....>>.>.....<<<<<<<<<.<<<....>>>.>.>>>>.>>>>......<<..<...........>..>>.........<<<<<<.......<<<....>>>............>>>>>>..>>>>>>.>>....<.<<...<<<.<<<.>>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>...<<<...<<<..<.<<<<<<.<<<........>>>>>>>>>.>..>>>..>>>...................................<<<<<<<<<<<<..<<..<<<<<..<<<.<<<<...<<<<<......<<<<<<.......<<.<<<........>>>.>>.....>>>>>>....<<<<<<<<<<<<<<.<<<.<<.<<....>>.<<......>>....>>.>>>....<<<...<...<..>..>.....<<<<<.....>>>>>........>>>....>>>.>>.>>>>>.>>>>...>>>>>>>>>.>>>.....<<.<<<..............>>>.>>......>>>>>.....<<<<<<<.........>>>>>>>......>>...>>>>>>>..........>>>>>..<<<<.<<..<.<<<<<<<<.<<<..<<<<.<<...<<<<<.<<<<<<<<<<<<.....>>>>>>>>>>>>...>>>>>...>>.>>>>..>>>.>>>>>>>>.>.>>.>>>>......<<<<<<<<<....>>>>>>>>> ....................((.((((((...(.((..(..(((..((....((....((..........))...))[))................(((.(.(..((....(((............[...((.....((.(((.....))).))......)).........((((...((((()))))...))))((..(((((.....((..(....(.((((((())).)))..).)..)..))......)))))......)).(]((((.(((((...).)))))))))...)))...))).).))).(((....(((....(((((((.........))))))))))......))).....((((((....).)))))......((.(((..........))).)).(.((....)).)..)))........((((...((((.]...))).))))).)...)).).....(((((((((.(((....))).).)))).))))....(.((..(...........)..))......)[.((((((.......(((....)))...........]))))))..)))))).))....(.((...(((.(((.)))...(((..(...(...((((..(((.((((((((...((........))......)))))))).))).......((....))...))))..)...)...))..))))...)).)...(((...(((..(.((((((.(((........))))))))).)..)))..)))........................(....).....((((((((((((..((..(((((..(((.((((...(((((.(....((((((....(..((.(((........))).))....)))))))....((((((((((((((.(((.((.((....)).((......))....)).)))....(((...(...(())..).....(((((.....)))))........)))....))).)).))))).)))).).))))))))).))).(...((.(((..............))).))...)..))))).....((.(((((.......))))).))......))...)))))))..........)))))..((((.((..(.((((((((.(((..((((.((...((((((((((((((((((.....)))))))))))).).)))))...)).))))..))).)))))))).).)).))))......(((((((((....))))))))) Cryo-EM structure of the human SSU processome, state pre-A1; 18S rRNA 7mq8 L2 215 3.6 RF00012,RF01848 URS000053962A_9606 34516797 0006396 0005730 9606 gacuauacuuucagggaucauuucuauaguguguuacuagagaaguuucucugaacguguagagcaccgaaaaccacgaggaagagagguagcguuuucuccugagcgugaagccggcuuucuggcguugcuuggcugcaacugccgucagccauugaugaucguucuucucuccguauuggggagugagagggagagaacgcggucugaguggu .........................................................................<<<<.....<<.......<<<<<<<<<<<<....<.......<<<<....<<<<<<<<......>>>>>.>>>...>>>>.........>..<<<<<<<<<<.....>>>>>>.>>>>>>>>>>>>>>>>...>>..>>>>. .........................................................................((((......(.......((((((((((((....(...(...((((..(.(((((.((......)).)).))))..))))..)......)..((((((((((.....)))))).))))))))))))))))...)...)))). Cryo-EM structure of the human SSU processome, state pre-A1; U3 snoRNA 7mq9 L0 242 3.87 RF00957 URS0002311998_9606 34516797 0035195 0016442 9606 gaucgauguggugacgucgugcucucccgggccggguccgcggaccccggcccgaccucgcgcgggguccucugacgcggcagacagcccucgcugucgccgacuugcgggcggccccccuccgcggcggugggggugccgucccgccggcccgugcgucggcuccgggcccuugcggugcuccuggagcgcuccggguugcaggugcccgaggccgaugagaaaagccuucucuagcgauc ...................<<.<<....<<<<<<<<<<<<>>>>>>>.>>>>><<<<<<<..>>>>>>>....>>>>.<<<<<......>>.>>><<<<.>>>>...<<<<<<<<<<<<<.<<<...>>>.>>>>>.>>>>>.>>>..<<<<<<..>>..>>>>...................................................<<.>>...................... ..................(((.((....(((((((((((())))))).)))))(((((((())))))))....)))))(((((......)).)))((((.))))..((((.(((((((((.(((...))).))))).)))).).))).((((((()))..))))...................................................(...)...................... Cryo-EM structure of the human SSU processome, state pre-A1*; 5'ETS rRNA 7mq9 L1 1301 3.87 RF01960,RF01959,RF00177 URS0002311A2E_9606 34516797 0003735 0005840 9606 accugguugauccugccaguagcauaugcuugucucaaaaagccaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucgcuccuuacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccggggggaugcgugcauuuaucagaucaaaaccaacccgccccucgggcgggcgccggcggcuuuggcuagauaaccucgggccgaucgcacgccccccguggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugagggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguagcuccaauagcguauauuaaaagcucguaguuggaucauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccagaguaugguugugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccguggguuggugcauggccguucguugguggagcgauuugguuaauuccgauaacgaacgagacucuggcaugcuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccguccgggcgcgcgcuacacugacuggcucagcguguaaccccauucguaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggucggcccacggcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagguuuccguaggugaaccugcggaa ....................<<.<<<<<<...<.<<.....<<<..<<....<<....<<..........>>...>>.>>........<.......<<<.<....<<....<<<................<<.....<<.<<.......>>.>>......>>.........<<<<...<<<<..>>>>...>>>><<..<<<<<.....<<..<...<<..<<<<<..>>.>>>....>>.>..>>......>>>>>......>>...<<<<.<<<<......>>>>>>>>....>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>....<<<<<<.......>>>>>>...>.<<.<<<<........>>>>.>>.<.<<<..>>>.>..>>>........<<<<....<<<.....>>>..>>>>.....>>.>.....<<<<<<<<<.<<<....>>>.>.>>>>.>>>>......<<..<...........>..>>.........<<<<<<.......<<<....>>>............>>>>>>..>>>>>>.>>....<.<<...<<<.<<<.>>>....<<<<<<..<...<<<<..<<<.<<<<<<<<...<<<......>>>......>>>>>>>>.>>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>...<<<...<<<..<.<<<<<<.<<<........>>>>>>>>>.>..>>>..>>>...................................<<<<<<<<<<<<..<<..<<<<<..<<<.<<<<...<<<<<......<<<<<<.......<<.<<<........>>>.>>.....>>>>>>....<<<<<<<<<<<<<<.<<<.<<.<<....>><<<......>>>...>>.>>>....<<<...<...<..>..>.....<<<<<.....>>>>>........>>>....>>>.>>.>>>>>.>>>>...>>>>>>>>>.>>>.....<<.<<<..............>>>.>>......>>>>>.....<<<<<<<.........>>>>>>>......>>...>>>>>>>..........>>>>>..<<<<.<<..<.<<<<<<<<.<<<..<<<<.<<...<<<<<.<<<<<<<<<<<<.....>>>>>>>>>>>>...>>>>>...>>.>>>>..>>>.>>>>>>>>.>.>>.>>>>......<<<<<<<<<....>>>>>>>>> ....................((.((.(((...(.((..(..(((..((....((....((..........))...))[))................(((.(.(..((....(((............[...((.....((.(((.....))).))......)).........((((...((((()))))...))))((..(((((.....((..(....(.((((((())).)))..).)..)..))......)))))......)).(]((((.(((((...).)))))))))...)))...))).).))).(((....(((....(((((((.........))))))))))......))).....((((((....).)))))......((.(((..........))).)).(.((....)).)..)))........((((...((((.]...))).))))).)...)).).....(((((((((.(((....))).).)))).))))....(.((..(...........)..))......)[.((((((.......(((....)))...........]))))))..))).)).))......((...(((.(((.)))...(((..(...(...((((..(((.((((((((...((........))......)))))))).))).......((....))...))))..)...)...))..))))...)).....(((...(((..(.((((((.(((........))))))))).)..)))..)))........................(....).....((((((((((((..((..(((((..(((.((((...(((((.(....((((((....(..((.(((........))).))....)))))))....((((((((((((((.(((.((.((....)).((......))....)).)))....(((...(...(())..).....(((((.....)))))........)))....))).)).))))).)))).).))))))))).))).(...((.(((..............))).))...)..))))).....((.(((((.......))))).))......))...)))))))..........)))))..((((.((..(.((((((((.(((..((((.((...((((((.(((((((((((.....)))))))))))..).)))))...)).))))..))).)))))))))..)).))))......(((((((((....))))))))) Cryo-EM structure of the human SSU processome, state pre-A1*; 18S rRNA 7mq9 L2 215 3.87 RF00012,RF01848 URS000053962A_9606 34516797 0006396 0005730 9606 gacuauacuuucagggaucauuucuauaguguguuacuagagaaguuucucugaacguguagagcaccgaaaaccacgaggaagagagguagcguuuucuccugagcgugaagccggcuuucuggcguugcuuggcugcaacugccgucagccauugaugaucguucuucucuccguauuggggagugagagggagagaacgcggucugaguggu .........................................................................<<<<.....<<.......<<<<<<<<<<<<....<.......<<<<....<<<.<<<<......>>>>..>>>...>>>>.........>..<<<<<<<<<<.....>>>>>>.>>>>>>>>>>>>>>>>...>>..>>>>. .........................................................................((((......(........(((((((((((....(...(...((((..(.(((((.((......)).)).))))..))))..)......)..((((((((((.....)))))).)))))))))))))))....)...)))). Cryo-EM structure of the human SSU processome, state pre-A1*; U3 snoRNA 7mqa L1 1636 2.7 RF01960,RF01959,RF00177 URS00023119A9_9606 34516797 0003735 0005840 9606 accugguugauccugccaguagcaunugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucnuuaaaucaguuauggunccuunggucgcucgcuccuuacuuggauaacugugguanuucuagngcuaananaugccgacgggcgcugacccccggggggaugcgugcauuuaucagaucaaaaccaacccgccccucgggcgggcgccggcggcuuuggugacucuagauaaccucgggccgaucgcacgccccccguggcggcgacgacccauucgaacgucngcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgaunccggaganggagccugagaaacggcuaccacauncaaggnaggcagcaggcgcgcnaauuacccacucccgacccggggangungugangaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaanuccuuuaacgaggnuccauuggagngcaagucuggugccagcagncgcggnagcuccaauancguauauuaaacugcaguunaaaagcucguaguungaucuugggagcgggcgggcgguccagccaccgcccguccccgccccuugccucucggcgccggcccgaagngnuuacuuugaaaaaauuagaguguucaaagcaggccccgccuggauaccgcagcuaggaauaaungggaccgcgguucuaggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagancgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccguggguuggugcauggccguucguugguggagcgauuugguuaauuccgauaacgaacgagacucuggcaugcuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccguccggggcacgcgcgcuacacugacuggcucagcguguguacgccggcaggcgcgaaccccauucgugauggggaucggggauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauunagucccugcccuuucacaccgnccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggucggcccacggcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaaguucnguaggugaaccugcggaaggaucauuaacg ..<<<<<.......>>>>>.<<.<<<<<<...<.<<.........<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<....<<....<<<................<<.....<<.<<.......>>.>>......>>.........<<<<...<<<<..>>>>...>>>><<..<<<<<.....<<..<...<<..<<<<<..>>.>>>....>>.>..>>...........>>>>>......>>...<<<<.<<<<......>>>>>>>>....>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>..>>>......>>.>.....<<<<<<<<<.<<<....>>>.>.>>>>.>>>>......<<..<...........>..>>.........<<<<<<.......<<<....>>>............>>>>>>..>>>>>>.>>......<.<((.....<.<<...<<<.<<<<<.<<<.<<<<<<<<<<<<<......>>>>>>>>>..>>>>>>>.<<<...<<<<.<<..>>>>>>.>>>.<<<<<<.<.......<<..<<.......>>.<<<...>>>....>>......>.>>>..>>>.>><<.<<.<<<<<<<.>>>>>>>.>>>>...>>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<........>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>......................................<<<<<<<<<<<<..<<..<<<<<..<<<.<<<<<<.<<<<<......<<<<<<.......<<.<<<........>>>.>>.....>>>>>>....<<<.<<<<<<<<<<.<<<.<<.<<....>>.<<......>>....>>.>>>....<<<...<...<..>..>.....<<<<<.....>>>>>........>>>....>>>.>>.>>>>>..>>>...>>>>>>>.>>>>.>>>.....<<.<<<.............<<<<....>>>>......>>>.>>......<.....<<<<<.<>.>>>>>.....>.....>>>>>.....<<<<<<<.........>>>>>>>......>>...>>>>>>>.........>>>>>..<<<<.<<..<.<<<<<<<<.<<<..<<<<.<<...<<<<<.<<<<<<<<<<<<.....>>>>>>>>>>>>...>>>>>...>>.>>>>..>>>.>>>>>>>>.>.>>.>>>>....<<<<<<<<<....>>>>>>>>>............ ..(((((.......))))).(...(((((......(..(......(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..((....(((............[...((.....((.(((.....))).))......)).........((((...((((()))))...))))((..(((((.....((..(....(.((((((())).)))..).)..)..)).(......)..)))))......)).(]((((.(((((...).)))))))))...)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).......(.(((...((((.]...))).))))).)...)........(((((((((.(((....))).).)))).))))....(.((..(...........)..))......)..((((((.......(.(....).)............))))))..)))))...)...[..(.([[...(.(.((...(.(..(.((.((...((((((((((((......)))))))))..)))..))..((...((((.((())))))).))..(..(((.(........(..((.......)).(((...)))....).......).)))....).))((.((.(((((((.))))))).))))....)....(((.((...(...(((...(((.((((((((...(..........)......)))))))).))).......((....))....)))..)...))..))..)).)...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.(((........))))))))).)..)))...((..]]))...))....]))))).)...........................(....).....((((((((((((..((..((.((..(((..(((((.(((((.(....((((((....(..((.(((........))).))....)))))))....((((((((((((((.(((.((.((....)).((......))....)).)))....(((...(...(())..).....(((((.....)))))........)))....))).)).))))).)))).).))))))).)))..))).(...((.(((...........(.((((....)))).)....))).))......(.....((((..()..)))).....)..)..)).)).....((.(((((.......))))).))......))...))))))).........)))))..((((.((..(.((((((((.(((..((((.((...(((((.((((((((((((.....))))))))))))...)))))...)).))))..))).)))))))))..)).))))....(((((((((....)))))))))}........... Cryo-EM structure of the human SSU processome, state post-A1; 18S rRNA 7mqa L2 177 2.7 RF00012,RF01848 URS000053962A_9606 34516797 0006396 0005730 9606 gacuauacuuucagggaucauaguguguuacuaaaccacgaggaagagagguagcguuuucuccugagcgugaagccggcuuucuggcguugcuuggcugcaacugccgucagccauugaugaucguucuucucuccguauuggggagugagagggagagaacgcggucugaguggu ..................................<<<<<.....<<.......<<<<<<<<<<<<....<.......<<<<....<<<<<<<<......>>>>>.>>>...>>>>.........>..<<<<<<<<<<.....>>>>>>.>>>>>>>>>>>>>>>>...>>..>>>>> ..................................(((((......(.......((((((((((((....(...(...((((..(.((((((((......))))).))))..))))..)......)..((((((((((.....)))))).))))))))))))))))...)...))))) Cryo-EM structure of the human SSU processome, state post-A1; U3 snoRNA 7msc A 3118 2.97 RF02540,RF02541,RF00002 URS00005E0FC6_83332 35064151 0003735 0005840 83332 aagugucuaagggcgcaugguggaugccuuggcaucgagagccgaugaaggacgugggaggcugcgauaugccucggggagcugucaaccgagcguggauccgaggauuuccgaauggggaaacccagcacgagugaugucgugcuacccgcaucugaauauauagggugcgggagggaacgcggggaagugaaacaucucaguacccguaggaggagaaaacaauugugauuccgcaaguaguggcgagcgaacgcggaacaggcuaaaccgcacgcauggguaaccggguagggguugugugugcgggguugugggaggauaugucucagcgcuacccggcugagaggcagucagaaagugucgugguuagcggaaguggccugggauggucugccguagacggugagagcccgguacgcgaaaacccggcaccugccuaguaucaauucccgaguagcagcgggcccguggaauccgcugugaauccgccgggaccacccgguaagccuaaauacuccucgaugaccgauagcggauuaguaccgugagggaauggugaaaaguaccccgggaggggagugaaagaguaccugaaaccgugugccuacaauccgucagagccuccuuuuccucuccggaggaggguggugauggcgugccuuuugaagaaugagccugcgagucagggacaugucgcaagguuaacccgugugggguagccgcagcgaaagcgagucugaauagggcgacccacacgcgcauacgcgcgugugaauaguggcguguucuggacccgaagcggagugaucuacccauggccagggugaagcgcggguaagaccgcguggaggcccgaacccacuuagguugaagacugaggggaugagcuguggguaggggugaaaggccaaucaaacuccgugauagcugguucuccccgaaaugcauuuaggugcagcguugcgugguucaccgcggagguagagcuacuggauggccgauggguuacugacgucagccaaacuccgaaugccgugguguaaagcguggcagugagacggcgggggauaagcuccguacgucgaaagggaaacagcccagaucgccggcuaaggcccccaagcgugugcuaagugggaaaggaugugcagucgcaaagacaaccaggagguuggcuuagaagcagccacccuugaaagagugcguaauagcucacuggucaagugauugugcgccgauaauguagcggggcucaagcacaccgccgaagccgcggcacauccaccuugugguggguguggguaggggagcgucccucauucagcgaagccaccgggugaccggugguggagggugggggagugagaaugcaggcaugaguagcgacaaggcaagugagaaccuugcccgccgaaagaccaaggguuccugggccaggccaguccgcccagggugagucgggaccuaaggcgaggccgacaggcguagucgauggacaacggguugauauucccguacccgugugugggcgcccgugacgaaucagcgguacuaaccacccaaaaccggaucgaucacuccccuucggggguguggaguucuggggcugcgugggaacuucgcugguaguagucaagcgaaggggugacgcaggaagguagccguaccagucagugguaacacuggggcaagccgguagggagagcgauaggcaaauccgucgcucacuaauccugagaggugacgcauagccgguugaggcgaauucggugauccucugcugccaagaaaagccucuagcgagcacacacacggcccguaccccaaaccgacacagguggucagguagagcauaccaaggcguacgagauaacuaugguuaaggaacucggcaaaaugcccccguaacuucgggagaagggggaccggaauaucgugaacacccuugcggugggagcgggauccggucgcagaaaccagugaggagcgacuguuuacuaaaaacacagguccgugcgaagucgcaagacgauguauacggacugacgccugcccggugcuggaagguuaagaggacccguuaacccgcaagggugaagcggagaauuuaagccccaguaaacggcggugguaacuauaaccauccuaagguagcgaaanuccuugucggguaaguuccgaccugcacgaauggcguaacgacuucucaacugucucaaccauagacucggcgaaauugcacuacgaguaaagaugcucguuacgcgcggcaggacgaaaagaccccgggaccuucacuacaacuugguauugauguucgguacgguuuguguaggauaggugggagacugugaaaccucgacgccaguuggggcggagucguuguugaaauaccacucugaucguauugggcaucuaaccucgaacccugaaucggguuuagggacagugccuggcggguaguuuaacuggggcgguugccuccuaaaauguaacggaggcgcccaaagguucccucaaccuggacggcaaucagguggcgaguguaaaugcacaagggagcuugacugcgagacuuacaagucaagcagggacgaaagucgggauuagugauccggcacccccgaguggaaggggugucgcucaacggauaaaagguaccccggggauaacaggcugaucuuccccaagaguccauaucgacgggaugguuuggcaccucgaugucggcucgucgcauccuggggcuggagcaggucccaaggguugggcunuucgcccauuaaagcggcacgcgagcuggguuuagaacgucgugagacaguucggucucuauccgccgcgcgcgucagaaacuugaggaaaccugucccuaguacgagaggaccgggacggacgaaccucuggugcaccaguugucccgccaggggcaccgcuggauagccacguucggucaggauaaccgcugaaagcaucuaagcgggaaaccuucuccaagaucagguuucucacccacuuggugggauaaggccccccgcagaacacggguucaauaggucagaccuggaagcucaguaauggguguagggaacuggugcuaaccggccgaaaacuu <<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<<......<<<<<<.[[.(((.>>>.....<<<<<<<..<<<)))..]].>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<<..>>>..<<<<<<.....<<.....>>....>>>>>>..<<<....<<<<<<<<<<......<<((((((>>...>>>>>>>>>>......<<<<<<<<<<..<<<<<<.)))))).>>>>>><<<<<<.......<<<<<<.<<<<.<<<.....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>>>.>>>>>..>>>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..>>>......>>.>>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>..<....<<<<..<<<.<<<<<.<.........>>>>>>.>>>..>>>>...<.<........>.>.<<<<<<....<<<.<<<<<<<<<<..<<<...<<<....>>>...>>>...<<....>>..<<<<.....>>>>.......<<...<....>...>>.......>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<....<<<<<<<<.....<<<....<<<.<<<<....<.....>....>>>>.>>>..>>.>.....>>>>>>>>....>>>>>>>.>>..<<<<<<<<<<......>>>>>>.>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<.........>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>...........)))......>>>>>>.>>>...>>>>>>><<<<<<<<<<....>>>>>>>>>>....>>>>>><.<<<<<<<<<.......<<<<<<<<....>>>>>>>>....>>>>>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<.<<.....<<<<...<<<<<<<......<<<<.<....<<<<<.<..<<<..<<<......>>>..>>>.>.>>>>>....>.>>>>.....>>>>>>>.....>>>>.<<..<<<<<<...<<<<..<<<..<<<<..<<<<<...((((...>>>>>.<<..<<<....<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>....>>>...>>...<<<......>>>.....>>>>...>>>...>>>>........>>>>>>.>>..>>.>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<...<<.....<..<<....>>..>......>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.<<<....<<<<<.<<<<....>>>>..>>>>>....>>>.>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.((..<<<<<......))>>>>>>.<<<<<<<<.<<<.<<......<<<<<<<<<<..<<<<<..<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<........<<<.<.......>.>>>......>>............>>>>>..>>>>>>>>>>>>>>>>...<<<.<<<<<<......>>>>>>>>>....>>>>>.>>...>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.<<..>>>>..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<.<<<<...<<.......>>...>>>>.>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>>>>>>>>>....<<<<<<<...<<<...<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))))>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>..>>>.......>>>>>>>..<<<<.....>>>>....<<<<.<<<<.......>>>>.....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>> (((.......((((((((((.....(((..(((((((((((((......((((((.[[.[[[.))).....((((((...(((]]]..]].)))......))))))...)))....(((....)))(((((((......))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((((((((((.....(([[[[[[))..)))))))))))....(.((((.(((((..((((((.]]]]]].))))))((((((.......((((((.((((.(((...(.((((......)))))[[(...).(((.....]])))...)))...)))))))))))))))).)))))...))))]....(((((((...[.......)))))))....).(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((..(((.((((..............)))).)))..)))).<.(.(........).).((((((....(((.((((((((((..(((...(((....)))...)))....(....)...((((.....)))).....(..(............)..).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.((((........A.)))))))..).))))))))).(.(((.....)))...)..))))))......).))..(((((.....(((((....)))))(((((((((....((((((((.....(((....(((.((((....((..).)....)))).)))..)).).....))))))))....))))))).))..((((((((((......)))))).))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(.(((..((...(...........)...))..........(.........)..))).)...)))))))))).))...........]]].)....))))))))))...)))))))((((((((((....)))))))))).....)))))(.((((((((((......((((((((....))))))))...))))))))))..).....))))))(......((.....((((((.......))))))((((....((((..((...((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(.(((........))).)]](((((((((.((.....((((....((((((.(....(((...(...(((.(......(..((((....))))..).....).)))...)...)))....)))))))......)))).((...(((((...((((..(((..((((..(((((....{{{...))))).((..(((....(((((((((((.((.....))))))))).....))))..[.)))...))...(((......))).....))))...)))...))))(..)....)))))..))..)).)))))))))))))..)).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.............(....].)...........))))))(...).......((((((((..].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((....((((..((((....))))...))))....))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))....).))))))).)..))).)))))))).)))))).....))[[..(((((.....>]])))))..((((((((.(((.((......(((((((.((..(((((..((.(((((.((((((((((((((((.(.........(((((..................(....).........................)))))).))))))))))))))))...(((.((((((......)))))))))....))))).))...)))))..(((......[)))((((((..........]))))))([((...(((((((.(..((((.........))))....).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......)).)..))))))......(((((.(.(.((((...((.......))...)))).)...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..a.))..)))))))))))[..<(((((((...(((...(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....)))..)))..]....)))))))..((((....>))))....((((.((((.......)))).....((((((((.(((....(((((....)))))...)))..))))).)))...)))).....))) Mtb 70SIC in complex with MtbEttA at Pre_R0 state; 23S rRNA 7msc B 115 2.97 RF00001 URS00005330B1_83332 35064151 0003735 0005840 83332 uuacggcggccacagcggcagggaaacgcccggucccauuccgaacccggaagcuaagccugccagcgccgaugauacugccccuccggguggaaaaguaggacaccgccgaaca <..<<<<<<.....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<.......<<<<<<....>>>>>>.......>>...>>>>>>.>.. ((.((((((.....((((((((.....((((((...(.....)...))))..))....)))))).)).((.......((((((....)))))).......))...)))))))).. Mtb 70SIC in complex with MtbEttA at Pre_R0 state; 5S rRNA 7msc a 1519 2.97 RF00177,RF01959,RF01960 URS00002C0A67_83332 35064151 0003735 0005840 83332 uggagaguuugauccuggcucaggacgaacgcuggcggcgugcuuaacacaugcaagucgaacggaaaggucucuucggagauacucgaguggcgaacgggugaguaacacgugggugaucugcccugcacuucgggauaagccugggaaacugggucuaauaccggauaggaccacgggaugcaugucuugugguggaaagcgcuuuagcggugugggaugagcccgcggccuaucagcuuguugguggggugacggccuaccaaggcgacgacggguagccggccugagaggguguccggccacacugggacugagauacggcccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagcgacgccgcgugggggaugacggccuucggguuguaaaccucuuucaccaucgacgaagguccggguucucucggauugacgguagguggagaagaagcaccggccaacuacgugccagcagccncgguaauacguagggugcgagcguuguccggaauuacugggcguaaagagcucguaggugguuugucgcguuguucgugaaaucucacggcuuaacugugagcgugcgggcgauacgggcagacuagaguacugcaggggagacuggaauuccugguguagcgguggaaugcgcagauaucaggaggaacaccgguggcgaaggcgggucucugggcaguaacugacgcugaggagcgaaagcguggggagcgaacaggauuagauacccugguaguccacgccguaaacgguggguacuagguguggguuuccuuccuugggauccgugccguagcuaacgcauuaaguaccccgccuggggaguacggccgcaaggcuaaaacucaaaggaauugacgggggcccgcacaagcggcggagcauguggauuaauucgaunnaacgcgaagaaccuuaccuggguuugacaugcacaggacgcgucuagagauaggcguucccuuguggccugugugcagguggugcauggcugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuugucucauguugccagcacguaaugguggggacucgugagagacugccggggucaacucggaggaagguggggaugacgucaagucaucaugccccuuauguccagggcuucacacaugcuacaauggccgguacaaagggcugcgaugccgcgagguuaagcgaauccuuaaaagccggucucaguucggaucggggucugcaacucgaccccgugaagucggagucgcuaguaaucgcagaucagcaacgcugcggugaauacguucccgggccuuguacacaccgnccgucacgucaugaaagucgguaacacccgaagccaguggccuaacccucgggagggagcugucgaaggugggaucggcgauugggacgaagucgnaacaagguagccguaccggnnggugcggcuggauc ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<..<<..<<<....>>>...>>>..>>>>>......<<........<<<<<<<..<<...<<<<<<<<<<<<.....<<<<<......>>>>>......>>>>.....<<<<<<<<<<....>>>>>>>>>>.....<<......>>>>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<<<<<<<......>>>>>>>.......>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<.....<<<<<<<.....>>>>>>>...>>>>>>>..>>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<<..<<<......>>>.....>>>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...........>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<.......<<<<<<..<<<.<.<....>.>.>>>............>>>>>>..<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<<..<<........>>>>.....>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<..<<<<....<.<<<<..<<<..<<....>>.>>>.>>>>.>...>>>>..>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(..(((....)))...)))..)))))......(((.......(((((((..((...(((.((((((((.....((((((....))))))......))))......(((((((((....)))))))))......((......)))))).)))..))))))))).(((....(((...(((((((.......))))))).)))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(..((.(............).))..)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((.....(((((((.....)))))))...))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((.(.......).))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((.(.(..(((.(.(....).).)))...........)..).)))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..((........))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((..((((....(.((((..(((..((....)).))).)))).)...))))..))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Mtb 70SIC in complex with MtbEttA at Pre_R0 state; 16S rRNA 7msc y 77 2.97 RF00005 URS000041AF00_83332 35064151 0030533 0006412 83332 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(.(((.......))).)))))))..... Mtb 70SIC in complex with MtbEttA at Pre_R0 state; initiator tRNA (Met) 7msf S 11 2.8 URS000080DDB1_32630 9808042,9461079,9245600,7523953,8254664 32630 gccaacaggcg <<<....>>>. (((....))). MS2 PROTEIN CAPSID/RNA COMPLEX; 5'-R(*UP*CP*GP*CP*CP*AP*AP*CP*AP*GP*GP*CP*GP*G)-3' 7msh A 3118 3.23 RF02540,RF02541,RF00002 URS00005E0FC6_83332 35064151 0003735 0005840 83332 aagugucuaagggcgcaugguggaugccuuggcaucgagagccgaugaaggacgugggaggcugcgauaugccucggggagcugucaaccgagcguggauccgaggauuuccgaauggggaaacccagcacgagugaugucgugcuacccgcaucugaauauauagggugcgggagggaacgcggggaagugaaacaucucaguacccguaggaggagaaaacaauugugauuccgcaaguaguggcgagcgaacgcggaacaggcuaaaccgcacgcauggguaaccggguagggguugugugugcgggguugugggaggauaugucucagcgcuacccggcugagaggcagucagaaagugucgugguuagcggaaguggccugggauggucugccguagacggugagagcccgguacgcgaaaacccggcaccugccuaguaucaauucccgaguagcagcgggcccguggaauccgcugugaauccgccgggaccacccgguaagccuaaauacuccucgaugaccgauagcggauuaguaccgugagggaauggugaaaaguaccccgggaggggagugaaagaguaccugaaaccgugugccuacaauccgucagagccuccuuuuccucuccggaggaggguggugauggcgugccuuuugaagaaugagccugcgagucagggacaugucgcaagguuaacccgugugggguagccgcagcgaaagcgagucugaauagggcgacccacacgcgcauacgcgcgugugaauaguggcguguucuggacccgaagcggagugaucuacccauggccagggugaagcgcggguaagaccgcguggaggcccgaacccacuuagguugaagacugaggggaugagcuguggguaggggugaaaggccaaucaaacuccgugauagcugguucuccccgaaaugcauuuaggugcagcguugcgugguucaccgcggagguagagcuacuggauggccgauggguuacugacgucagccaaacuccgaaugccgugguguaaagcguggcagugagacggcgggggauaagcuccguacgucgaaagggaaacagcccagaucgccggcuaaggcccccaagcgugugcuaagugggaaaggaugugcagucgcaaagacaaccaggagguuggcuuagaagcagccacccuugaaagagugcguaauagcucacuggucaagugauugugcgccgauaauguagcggggcucaagcacaccgccgaagccgcggcacauccaccuugugguggguguggguaggggagcgucccucauucagcgaagccaccgggugaccggugguggagggugggggagugagaaugcaggcaugaguagcgacaaggcaagugagaaccuugcccgccgaaagaccaaggguuccugggccaggccaguccgcccagggugagucgggaccuaaggcgaggccgacaggcguagucgauggacaacggguugauauucccguacccgugugugggcgcccgugacgaaucagcgguacuaaccacccaaaaccggaucgaucacuccccuucggggguguggaguucuggggcugcgugggaacuucgcugguaguagucaagcgaaggggugacgcaggaagguagccguaccagucagugguaacacuggggcaagccgguagggagagcgauaggcaaauccgucgcucacuaauccugagaggugacgcauagccgguugaggcgaauucggugauccucugcugccaagaaaagccucuagcgagcacacacacggcccguaccccaaaccgacacagguggucagguagagcauaccaaggcguacgagauaacuaugguuaaggaacucggcaaaaugcccccguaacuucgggagaagggggaccggaauaucgugaacacccuugcggugggagcgggauccggucgcagaaaccagugaggagcgacuguuuacuaaaaacacagguccgugcgaagucgcaagacgauguauacggacugacgccugcccggugcuggaagguuaagaggacccguuaacccgcaagggugaagcggagaauuuaagccccaguaaacggcggugguaacuauaaccauccuaagguagcgaaanuccuugucggguaaguuccgaccugcacgaauggcguaacgacuucucaacugucucaaccauagacucggcgaaauugcacuacgaguaaagaugcucguuacgcgcggcaggacgaaaagaccccgggaccuucacuacaacuugguauugauguucgguacgguuuguguaggauaggugggagacugugaaaccucgacgccaguuggggcggagucguuguugaaauaccacucugaucguauugggcaucuaaccucgaacccugaaucggguuuagggacagugccuggcggguaguuuaacuggggcgguugccuccuaaaauguaacggaggcgcccaaagguucccucaaccuggacggcaaucagguggcgaguguaaaugcacaagggagcuugacugcgagacuuacaagucaagcagggacgaaagucgggauuagugauccggcacccccgaguggaaggggugucgcucaacggauaaaagguaccccggggauaacaggcugaucuuccccaagaguccauaucgacgggaugguuuggcaccucgaugucggcucgucgcauccuggggcuggagcaggucccaaggguugggcunuucgcccauuaaagcggcacgcgagcuggguuuagaacgucgugagacaguucggucucuauccgccgcgcgcgucagaaacuugaggaaaccugucccuaguacgagaggaccgggacggacgaaccucuggugcaccaguugucccgccaggggcaccgcuggauagccacguucggucaggauaaccgcugaaagcaucuaagcgggaaaccuucuccaagaucagguuucucacccacuuggugggauaaggccccccgcagaacacggguucaauaggucagaccuggaagcucaguaauggguguagggaacuggugcuaaccggccgaaaacuu 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((........((((((((((.....(((..((((((((((.((......((((((.[[.[[[.))).....((((((...((.]]]..]]..))......))))))...)))....(((....)))(((((((......))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((((((((((.....(([[[[[[))..)))))))))))....(.((((.(((((..((((((.]]]]]].))))))((((((.......((((((.((((.(((...(.((((......)))))[[(...).(((.....]])))...)))...)))))))))))))))).)))))...))))]....(((((((...[.......)))))))....).(((((].[[[[)))))..))).......).))))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((..(((.((.(..............).)).)))..)))).[.(.(........).).((((((..(.(((.((((((((((..(((...(((....)))...)))....(....)...((((.....)))).....(..(............)..).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.((((........<.)))))))..).))))))))).(.(((.....)))...)..))))))......).))).(((((.....(((((....)))))(((((((((....((((((((.....(((....(((.((.(....(.....)....).)).)))..)).).....))))))))....))))))).))..((((((((((......)))))).))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((..((((.....{........((...................))..........((......))...........))))..)))).))...........]]].)....))))))))))...)))))))((((((((((....)))))))))).....)))))(.((((((((((......((((((((....))))))))...))))))))))..).....))))))(......((.....((((((.......))))))((((....((((..((...((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(.(((........))).)]](((((((((.((.....((((.....((.(.................(..(.....(.((.((.(....).)).)).)....)...)..............)..)).......)))).((...(((((...((((..(((..((((..(((((....{{{...))))).((..(.(....(((((.(((((.((.....))))))).).....))))..[.).)...))...(((......))).....))))...)))...))))(..)....)))))..))..)).)))))))))))))..)).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))(((((...................]..............)))))(...).......((((((((..].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(.(((((..(((...((....((((..((((....))))...))))....))...))))))))...))))(((.(.........).)))........((..........(((((.......)))))..)..)....))))....).))))))).)..))).)))))))).)))))).....)){...(((((.....].})))))..(((.((((..((.((......(((((((.((..(((((..((.(((((.(((((((.((((((((.(..........((.(.................................................).)).).)))))))).)))))))...(((.((((((......)))))))))....))))).))...)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......)).)..)))))).......((((.(.(.((((...((.......))...)))).)...)))).)........((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.))..).))))).)))[...(((((((...(((...(((((((...............))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))....((....((((.....}.......))))....))...)))..]....)))))))..((((.....))))....((((..(((.......)))......((((((((.(((....(((((....)))))...)))..))))).)))...))))......)) Mtb 70SIC in complex with MtbEttA at Pre_R1 state; 23S rRNA 7msh B 115 3.23 RF00001 URS00005330B1_83332 35064151 0003735 0005840 83332 uuacggcggccacagcggcagggaaacgcccggucccauuccgaacccggaagcuaagccugccagcgccgaugauacugccccuccggguggaaaaguaggacaccgccgaaca ...<<<<<<.....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<.......<<<<<<....>>>>>>.......>>...>>>>>>.... (..((((((.....(..(((((.....(.((((...(.....)...))))...)....)))))...).((.......((((((....)))))).......))...)))))).).. Mtb 70SIC in complex with MtbEttA at Pre_R1 state; 5S rRNA 7msh a 1519 3.23 RF00177,RF01959,RF01960 URS00002C0A67_83332 35064151 0003735 0005840 83332 uggagaguuugauccuggcucaggacgaacgcuggcggcgugcuuaacacaugcaagucgaacggaaaggucucuucggagauacucgaguggcgaacgggugaguaacacgugggugaucugcccugcacuucgggauaagccugggaaacugggucuaauaccggauaggaccacgggaugcaugucuugugguggaaagcgcuuuagcggugugggaugagcccgcggccuaucagcuuguugguggggugacggccuaccaaggcgacgacggguagccggccugagaggguguccggccacacugggacugagauacggcccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagcgacgccgcgugggggaugacggccuucggguuguaaaccucuuucaccaucgacgaagguccggguucucucggauugacgguagguggagaagaagcaccggccaacuacgugccagcagccncgguaauacguagggugcgagcguuguccggaauuacugggcguaaagagcucguaggugguuugucgcguuguucgugaaaucucacggcuuaacugugagcgugcgggcgauacgggcagacuagaguacugcaggggagacuggaauuccugguguagcgguggaaugcgcagauaucaggaggaacaccgguggcgaaggcgggucucugggcaguaacugacgcugaggagcgaaagcguggggagcgaacaggauuagauacccugguaguccacgccguaaacgguggguacuagguguggguuuccuuccuugggauccgugccguagcuaacgcauuaaguaccccgccuggggaguacggccgcaaggcuaaaacucaaaggaauugacgggggcccgcacaagcggcggagcauguggauuaauucgaunnaacgcgaagaaccuuaccuggguuugacaugcacaggacgcgucuagagauaggcguucccuuguggccugugugcagguggugcauggcugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuugucucauguugccagcacguaaugguggggacucgugagagacugccggggucaacucggaggaagguggggaugacgucaagucaucaugccccuuauguccagggcuucacacaugcuacaauggccgguacaaagggcugcgaugccgcgagguuaagcgaauccuuaaaagccggucucaguucggaucggggucugcaacucgaccccgugaagucggagucgcuaguaaucgcagaucagcaacgcugcggugaauacguucccgggccuuguacacaccgnccgucacgucaugaaagucgguaacacccgaagccaguggccuaacccucgggagggagcugucgaaggugggaucggcgauugggacgaagucgnaacaagguagccguaccggnnggugcggcuggauc ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<......<<<.<<<..<<<..<<.<..<<..<<.<..>.>>...>>>..>>>>>......<<........<<<<<<<..<<...<<<<<<<<<<<<....<<<<<<......>>>>>.>....>>>>.....<<<<<<<<<<....>>>>>>>>>>.....<<......>>>>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>...>.>>>>>>..<<<<......<<<<....>>>>.....>>>>.....<<<<<......<<<<<<<......>>>>>>>.......>>>>>.......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<.....<<<<<<<.....>>>>>>>...>>>>>>>..>>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<.........>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<...<<<.<.<....>.>.>>>.............>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<....<<......>>..>.....>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<....<<<....>>>....>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<..<<<<....<.<<<<..<<<..<<....>>.>>>.>>>>.>...>>>>..>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>..... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(....(....).....)))..)))))......(((.......(((((((..((...(((.(((.((((.....((((((....))))))......)))).......((((.(.(....).).))).)......((......)).))).)))..))))))))).(((.....((..((((((((.......)))))))))).......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(..((((...(..((.((..........)).))..)....)))).....)..(((.([[[......((.....((.]]])).......))....))))..)))))))))..........((([[...(.((((...(((.(((((((..((.((((.(.....(((((((.....)))))))...).)))).)..).)))))))..((((((((.....(((((((....(((.((....((........)).......)).)))....).......((....)).))))))....)))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.......))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..(((((((.(.......((........))..........(.(((((..(...(((((....(((.(.(....).).)))..............)))))).(..(((...((.(.(.(....(((((((((....)))....((......))....)))))).....((((.(((((((...((....(......)..))....)))))))..(...((.(.....).))......)..)))).....).)..)....)).))).)....))))).)..[.)..))))))).(...((((((......(((..((...(((....)))...))....)))......))))))......(....(((..((........))..)))....)..)..))))).....((.(.((......]...)).).))......))...)))))))))).))..(.(..((.(.((.(.(((..((((((..((((....(.((((..(((..((....)).))).)))).)...))))..))))))..))).).))..).))...)..)..(((.(((((....))))).)))}.... Mtb 70SIC in complex with MtbEttA at Pre_R1 state; 16S rRNA 7msh y 75 3.23 RF00005 URS000041AF00_83332 35064151 0030533 0006412 83332 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaac .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.......<<<.......>>>..>>>>>>... .((((((..((((......[..)))).(((((.......)))))........((..]....))...))))))... Mtb 70SIC in complex with MtbEttA at Pre_R1 state; initiator tRNA (Met) 7msm A 3118 2.79 RF02540,RF02541,RF00002 URS00005E0FC6_83332 35064151 0003735 0005840 83332 aagugucuaagggcgcaugguggaugccuuggcaucgagagccgaugaaggacgugggaggcugcgauaugccucggggagcugucaaccgagcguggauccgaggauuuccgaauggggaaacccagcacgagugaugucgugcuacccgcaucugaauauauagggugcgggagggaacgcggggaagugaaacaucucaguacccguaggaggagaaaacaauugugauuccgcaaguaguggcgagcgaacgcggaacaggcuaaaccgcacgcauggguaaccggguagggguugugugugcgggguugugggaggauaugucucagcgcuacccggcugagaggcagucagaaagugucgugguuagcggaaguggccugggauggucugccguagacggugagagcccgguacgcgaaaacccggcaccugccuaguaucaauucccgaguagcagcgggcccguggaauccgcugugaauccgccgggaccacccgguaagccuaaauacuccucgaugaccgauagcggauuaguaccgugagggaauggugaaaaguaccccgggaggggagugaaagaguaccugaaaccgugugccuacaauccgucagagccuccuuuuccucuccggaggaggguggugauggcgugccuuuugaagaaugagccugcgagucagggacaugucgcaagguuaacccgugugggguagccgcagcgaaagcgagucugaauagggcgacccacacgcgcauacgcgcgugugaauaguggcguguucuggacccgaagcggagugaucuacccauggccagggugaagcgcggguaagaccgcguggaggcccgaacccacuuagguugaagacugaggggaugagcuguggguaggggugaaaggccaaucaaacuccgugauagcugguucuccccgaaaugcauuuaggugcagcguugcgugguucaccgcggagguagagcuacuggauggccgauggguuacugacgucagccaaacuccgaaugccgugguguaaagcguggcagugagacggcgggggauaagcuccguacgucgaaagggaaacagcccagaucgccggcuaaggcccccaagcgugugcuaagugggaaaggaugugcagucgcaaagacaaccaggagguuggcuuagaagcagccacccuugaaagagugcguaauagcucacuggucaagugauugugcgccgauaauguagcggggcucaagcacaccgccgaagccgcggcacauccaccuugugguggguguggguaggggagcgucccucauucagcgaagccaccgggugaccggugguggagggugggggagugagaaugcaggcaugaguagcgacaaggcaagugagaaccuugcccgccgaaagaccaaggguuccugggccaggccaguccgcccagggugagucgggaccuaaggcgaggccgacaggcguagucgauggacaacggguugauauucccguacccgugugugggcgcccgugacgaaucagcgguacuaaccacccaaaaccggaucgaucacuccccuucggggguguggaguucuggggcugcgugggaacuucgcugguaguagucaagcgaaggggugacgcaggaagguagccguaccagucagugguaacacuggggcaagccgguagggagagcgauaggcaaauccgucgcucacuaauccugagaggugacgcauagccgguugaggcgaauucggugauccucugcugccaagaaaagccucuagcgagcacacacacggcccguaccccaaaccgacacagguggucagguagagcauaccaaggcguacgagauaacuaugguuaaggaacucggcaaaaugcccccguaacuucgggagaagggggaccggaauaucgugaacacccuugcggugggagcgggauccggucgcagaaaccagugaggagcgacuguuuacuaaaaacacagguccgugcgaagucgcaagacgauguauacggacugacgccugcccggugcuggaagguuaagaggacccguuaacccgcaagggugaagcggagaauuuaagccccaguaaacggcggugguaacuauaaccauccuaagguagcgaaanuccuugucggguaaguuccgaccugcacgaauggcguaacgacuucucaacugucucaaccauagacucggcgaaauugcacuacgaguaaagaugcucguuacgcgcggcaggacgaaaagaccccgggaccuucacuacaacuugguauugauguucgguacgguuuguguaggauaggugggagacugugaaaccucgacgccaguuggggcggagucguuguugaaauaccacucugaucguauugggcaucuaaccucgaacccugaaucggguuuagggacagugccuggcggguaguuuaacuggggcgguugccuccuaaaauguaacggaggcgcccaaagguucccucaaccuggacggcaaucagguggcgaguguaaaugcacaagggagcuugacugcgagacuuacaagucaagcagggacgaaagucgggauuagugauccggcacccccgaguggaaggggugucgcucaacggauaaaagguaccccggggauaacaggcugaucuuccccaagaguccauaucgacgggaugguuuggcaccucgaugucggcucgucgcauccuggggcuggagcaggucccaaggguugggcunuucgcccauuaaagcggcacgcgagcuggguuuagaacgucgugagacaguucggucucuauccgccgcgcgcgucagaaacuugaggaaaccugucccuaguacgagaggaccgggacggacgaaccucuggugcaccaguugucccgccaggggcaccgcuggauagccacguucggucaggauaaccgcugaaagcaucuaagcgggaaaccuucuccaagaucagguuucucacccacuuggugggauaaggccccccgcagaacacggguucaauaggucagaccuggaagcucaguaauggguguagggaacuggugcuaaccggccgaaaacuu 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(((.......((((((((((.....(((..(((((((((((((......((((((.[[.[[[.))).....((((((...(((]]]..]].)))......))))))...)))....(((....)))(((((((......))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((((((((((.....(([[[[[[))..)))))))))))....(.((((.(((((..((((((.]]]]]].))))))((((((.......((((((.((((.(((...(.((((......)))))[[(...).(((.....]])))...)))...)))))))))))))))).)))))...))))]....(((((((...[.......)))))))....).(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((..(((.(((.(.((.....)..).)))).)))..)))).<.(.(........).).((((((....(((.((((((((((..(((...(((....)))...)))....(....)...((((.....)))).....(..(............)..).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.((((........A.)))))))..).))))))))).(.(((.....)))...)..))))))......).))..(((((.....(((((....)))))(((((((((....((((((((.....(((....(((.((((....((..).)....)))).)))..)).).....))))))))....))))))).))..((((((((((......)))))).))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{...(((.(((...................))).........((......))...))).....)))))))))).))...........]]].)....))))))))))...)))))))((((((((((....)))))))))).....)))))(.((((((((((......((((((((....))))))))...))))))))))..).....))))))(......((.....((((((.......))))))((((....((((..((...((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(.(((........))).)]](((((((((.((.....((((....((((........(((..((...((.((......(..(..(....)..)..).....))..))..)..)))).......))))......)))).((...(((((...((((..(((..((((..(((((....{{{...))))).((..(((....(((((((((((.((.....))))))))).....))))..[.)))...))...(((......))).....))))...)))...))))(..)....)))))..))..)).)))))))))))))..)).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((..................].............))))))(...).......((((((((..].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((....((((..((((....))))...))))....))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))....).))))))).)..))).)))))))).)))))).....))[[..(((((.....>]])))))..((((((((.(((.((......(((((((.((..(((((..((.(((((.((((((((((((((((.(.........(..((.................................................))..)).))))))))))))))))...(((.((((((......)))))))))....))))).))...)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......)).)..))))))......(((((.(.(.((((...((.......))...)))).)...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..a.))..)))))))))))[..<(((((((...(((...(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....)))..)))..]....)))))))..((((....>))))....((((.((((.......)))).....((((((((.(((....(((((....)))))...)))..))))).)))...)))).....))) Mtb 70SIC in complex with MtbEttA at Trans_R0 state; 23S rRNA 7msm B 115 2.79 RF00001 URS00005330B1_83332 35064151 0003735 0005840 83332 uuacggcggccacagcggcagggaaacgcccggucccauuccgaacccggaagcuaagccugccagcgccgaugauacugccccuccggguggaaaaguaggacaccgccgaaca <<.<<<<<<.....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<.......<<<<<<....>>>>>>.......>>...>>>>>>>>.. ((.((((((.....((((((((.....((((((...(.....)...))))..))....)))))).)).((.......((((((....)))))).......))...)))))))).. Mtb 70SIC in complex with MtbEttA at Trans_R0 state; 5S rRNA 7msm a 1519 2.79 RF00177,RF01959,RF01960 URS00002C0A67_83332 35064151 0003735 0005840 83332 uggagaguuugauccuggcucaggacgaacgcuggcggcgugcuuaacacaugcaagucgaacggaaaggucucuucggagauacucgaguggcgaacgggugaguaacacgugggugaucugcccugcacuucgggauaagccugggaaacugggucuaauaccggauaggaccacgggaugcaugucuugugguggaaagcgcuuuagcggugugggaugagcccgcggccuaucagcuuguugguggggugacggccuaccaaggcgacgacggguagccggccugagaggguguccggccacacugggacugagauacggcccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagcgacgccgcgugggggaugacggccuucggguuguaaaccucuuucaccaucgacgaagguccggguucucucggauugacgguagguggagaagaagcaccggccaacuacgugccagcagccncgguaauacguagggugcgagcguuguccggaauuacugggcguaaagagcucguaggugguuugucgcguuguucgugaaaucucacggcuuaacugugagcgugcgggcgauacgggcagacuagaguacugcaggggagacuggaauuccugguguagcgguggaaugcgcagauaucaggaggaacaccgguggcgaaggcgggucucugggcaguaacugacgcugaggagcgaaagcguggggagcgaacaggauuagauacccugguaguccacgccguaaacgguggguacuagguguggguuuccuuccuugggauccgugccguagcuaacgcauuaaguaccccgccuggggaguacggccgcaaggcuaaaacucaaaggaauugacgggggcccgcacaagcggcggagcauguggauuaauucgaunnaacgcgaagaaccuuaccuggguuugacaugcacaggacgcgucuagagauaggcguucccuuguggccugugugcagguggugcauggcugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuugucucauguugccagcacguaaugguggggacucgugagagacugccggggucaacucggaggaagguggggaugacgucaagucaucaugccccuuauguccagggcuucacacaugcuacaauggccgguacaaagggcugcgaugccgcgagguuaagcgaauccuuaaaagccggucucaguucggaucggggucugcaacucgaccccgugaagucggagucgcuaguaaucgcagaucagcaacgcugcggugaauacguucccgggccuuguacacaccgnccgucacgucaugaaagucgguaacacccgaagccaguggccuaacccucgggagggagcugucgaaggugggaucggcgauugggacgaagucgnaacaagguagccguaccggnnggugcggcuggauc ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<......<<<.<<<..<<<..<<.<..<<..<<<....>>>...>>>..>>>>>......<<........<<<<<<<..<<...<<<<<<<<<<<<.....<<<<<......>>>>>......>>>>.....<<<<<<<<<<....>>>>>>>>>>.....<<......>>>>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>...>.>>>>>>..<<<<......<<<<....>>>>.....>>>>.....<<<<<......<<<<.<<......>>.>>>>.......>>>>>.......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<.....<<<<<<<.....>>>>>>>...>>>>>>>..>>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<<..<<<......>>>.....>>>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<.<........>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<....<<<.<.<....>.>.>>>..............>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<<..<<<......>>>>>.....>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<..<<<<....<.<<<<..<<<..<<....>>.>>>.>>>>.>...>>>>..>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>..... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(...((....))....)))..)))))......(((.......(((((((..((...(((.((((((((.....((((((....))))))......))))......(((((((((....)))))))))......((......)))))).)))..))))))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(..(..(............)..)..)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((.....(((((((.....)))))))...))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((.(.......).))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(.((.....(((.(.(....).).)))...............)).)).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((......)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((..((((....(.((((..(((..((....)).))).)))).)...))))..))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Mtb 70SIC in complex with MtbEttA at Trans_R0 state; 16S rRNA 7msm y 77 2.79 RF00005 URS000041AF00_83332 35064151 0030533 0006412 83332 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Mtb 70SIC in complex with MtbEttA at Trans_R0 state; initiator tRNA (Met) 7msz A 3118 3.1 RF02540,RF02541,RF00002 URS00005E0FC6_83332 35064151 0003735 0005840 83332 aagugucuaagggcgcaugguggaugccuuggcaucgagagccgaugaaggacgugggaggcugcgauaugccucggggagcugucaaccgagcguggauccgaggauuuccgaauggggaaacccagcacgagugaugucgugcuacccgcaucugaauauauagggugcgggagggaacgcggggaagugaaacaucucaguacccguaggaggagaaaacaauugugauuccgcaaguaguggcgagcgaacgcggaacaggcuaaaccgcacgcauggguaaccggguagggguugugugugcgggguugugggaggauaugucucagcgcuacccggcugagaggcagucagaaagugucgugguuagcggaaguggccugggauggucugccguagacggugagagcccgguacgcgaaaacccggcaccugccuaguaucaauucccgaguagcagcgggcccguggaauccgcugugaauccgccgggaccacccgguaagccuaaauacuccucgaugaccgauagcggauuaguaccgugagggaauggugaaaaguaccccgggaggggagugaaagaguaccugaaaccgugugccuacaauccgucagagccuccuuuuccucuccggaggaggguggugauggcgugccuuuugaagaaugagccugcgagucagggacaugucgcaagguuaacccgugugggguagccgcagcgaaagcgagucugaauagggcgacccacacgcgcauacgcgcgugugaauaguggcguguucuggacccgaagcggagugaucuacccauggccagggugaagcgcggguaagaccgcguggaggcccgaacccacuuagguugaagacugaggggaugagcuguggguaggggugaaaggccaaucaaacuccgugauagcugguucuccccgaaaugcauuuaggugcagcguugcgugguucaccgcggagguagagcuacuggauggccgauggguuacugacgucagccaaacuccgaaugccgugguguaaagcguggcagugagacggcgggggauaagcuccguacgucgaaagggaaacagcccagaucgccggcuaaggcccccaagcgugugcuaagugggaaaggaugugcagucgcaaagacaaccaggagguuggcuuagaagcagccacccuugaaagagugcguaauagcucacuggucaagugauugugcgccgauaauguagcggggcucaagcacaccgccgaagccgcggcacauccaccuugugguggguguggguaggggagcgucccucauucagcgaagccaccgggugaccggugguggagggugggggagugagaaugcaggcaugaguagcgacaaggcaagugagaaccuugcccgccgaaagaccaaggguuccugggccaggccaguccgcccagggugagucgggaccuaaggcgaggccgacaggcguagucgauggacaacggguugauauucccguacccgugugugggcgcccgugacgaaucagcgguacuaaccacccaaaaccggaucgaucacuccccuucggggguguggaguucuggggcugcgugggaacuucgcugguaguagucaagcgaaggggugacgcaggaagguagccguaccagucagugguaacacuggggcaagccgguagggagagcgauaggcaaauccgucgcucacuaauccugagaggugacgcauagccgguugaggcgaauucggugauccucugcugccaagaaaagccucuagcgagcacacacacggcccguaccccaaaccgacacagguggucagguagagcauaccaaggcguacgagauaacuaugguuaaggaacucggcaaaaugcccccguaacuucgggagaagggggaccggaauaucgugaacacccuugcggugggagcgggauccggucgcagaaaccagugaggagcgacuguuuacuaaaaacacagguccgugcgaagucgcaagacgauguauacggacugacgccugcccggugcuggaagguuaagaggacccguuaacccgcaagggugaagcggagaauuuaagccccaguaaacggcggugguaacuauaaccauccuaagguagcgaaanuccuugucggguaaguuccgaccugcacgaauggcguaacgacuucucaacugucucaaccauagacucggcgaaauugcacuacgaguaaagaugcucguuacgcgcggcaggacgaaaagaccccgggaccuucacuacaacuugguauugauguucgguacgguuuguguaggauaggugggagacugugaaaccucgacgccaguuggggcggagucguuguugaaauaccacucugaucguauugggcaucuaaccucgaacccugaaucggguuuagggacagugccuggcggguaguuuaacuggggcgguugccuccuaaaauguaacggaggcgcccaaagguucccucaaccuggacggcaaucagguggcgaguguaaaugcacaagggagcuugacugcgagacuuacaagucaagcagggacgaaagucgggauuagugauccggcacccccgaguggaaggggugucgcucaacggauaaaagguaccccggggauaacaggcugaucuuccccaagaguccauaucgacgggaugguuuggcaccucgaugucggcucgucgcauccuggggcuggagcaggucccaaggguugggcunuucgcccauuaaagcggcacgcgagcuggguuuagaacgucgugagacaguucggucucuauccgccgcgcgcgucagaaacuugaggaaaccugucccuaguacgagaggaccgggacggacgaaccucuggugcaccaguugucccgccaggggcaccgcuggauagccacguucggucaggauaaccgcugaaagcaucuaagcgggaaaccuucuccaagaucagguuucucacccacuuggugggauaaggccccccgcagaacacggguucaauaggucagaccuggaagcucaguaauggguguagggaacuggugcuaaccggccgaaaacuu <<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<<......<<<<<<.[[.(((.>>>.....<<<<<<<..<<<)))..]].>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<....<<<<<<<<<<......<<((((((>>...>>>>>>>>>>......<<<<<<<<<<..<<<<<<.)))))).>>>>>><<<<<<.......<<<<<<.<<<<.<<<.....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>>>.>>>>>..>>>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..>>>......>>.>>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>..<....<<<<..<<<.<<<..<..........>..>>>.>>>..>>>>...<.<........>.>.<<<<<<....<<<.<<<<<<<<<<..<<<...<<<....>>>...>>>...<<....>>..<<<<.....>>>>......<.<<<........>>>.>......>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<....<<<<<<<<.....<<<....<<<.<<<<...............>>>>.>>>..>>.>.....>>>>>>>>....>>>>>>>.>>..<<<<<<<<<<......>>>>>>.>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<.<<.<<.....................>>.........<<......>>...>>.>>....>>>>>>>>>.>>...........)))......>>>>>>.>>>...>>>>>>><<<<<<<<<<....>>>>>>>>>>....>>>>>><.<<<<<<<<<.......<<<<<<<<....>>>>>>>>....>>>>>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<.<.<<<...<<<....>>>...>>>..>>>...<<<<<........>>>>>))<<<<<<<<<.<<.....<<<<....<<<.........<<<<.<<....<.<<<...<<....<<......>>....>>.>.>>..>...>>.>>>>........>>>......>>>>.<<..<<<<<<...<<<<..<<<..<<<<..<<<<<...((((...>>>>>.<<..<<<....<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>....>>>...>>...<<<......>>>.....>>>>...>>>...>>>>........>>>>>>.>>..>>.>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<....<<..>>.....>>>>><<<<<<...<<.......<<.....>>.........>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.<<<....<<<<<.<<<<....>>>>..>>>>>....>>>.>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.(...<<<<<.......)>>>>>>.<<<<<<<<.<<<.<<......<<<<<<<<<<..<<<<<..<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<.<................................................>>>>>..>>>>>>>>>>>>>>>>...<<<.<<<<<<......>>>>>>>>>....>>>>>.>>...>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.<<..>>>>..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<.<<<<...<<.......>>...>>>>.>....>>>.>.......<<<<<.<.<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>...>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>>>>>>>>>....<<<<<<<...<<<...<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<.)))).>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>..>>>.......>>>>>>>..<<<<.....>>>>....<<<<.<<<<.......>>>>.....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>> (((.......((((((((((.....(((..(((((((((((((......((((((.[[.[[[.))).....((((((...(((]]]..]].)))......))))))...)))....(((....)))(((((((......))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((((((((((.....(([[[[[[))..)))))))))))....(.((((.(((((..((((((.]]]]]].))))))((((((.......((((((.((((.(((...(.((((......)))))[[(...).(((.....]])))...)))...)))))))))))))))).)))))...))))]....(((((((...[.......)))))))....).(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((..(((.(((................))).)))..)))).<.(.(........).).((((((....(((.((((((((((..(((...(((....)))...)))....(....)...((((.....))))......(................)......)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.((((........A.)))))))..).))))))))).(.(((.....)))...)..))))))......).))..(((((.....(((((....)))))(((((((((....((((((((.....(((....(((.((((.....(..)......)))).)))..)).).....))))))))....))))))).))..((((((((((......)))))).))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{....((..((.....(........)....))..........((......))...))......)))))))))).))...........]]].)....))))))))))...)))))))((((((((((....)))))))))).....)))))(.((((((((((......((((((((....))))))))...))))))))))..).....))))))(......((.....((((((.......))))))((((....((((..((...((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(.(((........))).)]](((((((((.((.....((((....(((.(.......(.....(....((......(......(......)......).....).)...).....).....)..)))......)))).((...(((((...((((..(((..((((..(((((....{{{...))))).((..(((....(((((((((((.((.....))))))))).....))))..[.)))...))...(((......))).....))))...)))...))))(..)....)))))..))..)).)))))))))))))..)).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.............(....])............))))))(...).......((((((((..].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((....((((..((((....))))...))))....))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))....).))))))).)..))).)))))))).)))))).....))[[..(((((.....>]])))))..((((((((.(((.((......(((((((.((..(((((..((.(((((.((((((((((((((((.(................................(....)..............................).))))))))))))))))...(((.((((((......)))))))))....))))).))...)))))..(((......[)))((((((..........]))))))([((...(((((((.(..((((.........))))....).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......)).)..))))))......(((((.(.(.((((...((.......))...)))).)...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..a.))..)))))))))))[..<(((((((...(((...(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....)))..)))..]....)))))))..((((....>))))....((((.((((.......)))).....((((((((.(((....(((((....)))))...)))..))))).)))...)))).....))) Mtb 70SIC in complex with MtbEttA at Trans_R1 state; 23S rRNA 7msz B 115 3.1 RF00001 URS00005330B1_83332 35064151 0003735 0005840 83332 uuacggcggccacagcggcagggaaacgcccggucccauuccgaacccggaagcuaagccugccagcgccgaugauacugccccuccggguggaaaaguaggacaccgccgaaca <..<<<<<<.....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<........<<<<<....>>>>>........>>...>>>>>>.>.. (..((((((.....((((((((.....(.((((.............))))...)....)))))).)).((.......((((((....)))))).......))...)))))).).. Mtb 70SIC in complex with MtbEttA at Trans_R1 state; 5S rRNA 7msz a 1519 3.1 RF00177,RF01959,RF01960 URS00002C0A67_83332 35064151 0003735 0005840 83332 uggagaguuugauccuggcucaggacgaacgcuggcggcgugcuuaacacaugcaagucgaacggaaaggucucuucggagauacucgaguggcgaacgggugaguaacacgugggugaucugcccugcacuucgggauaagccugggaaacugggucuaauaccggauaggaccacgggaugcaugucuugugguggaaagcgcuuuagcggugugggaugagcccgcggccuaucagcuuguugguggggugacggccuaccaaggcgacgacggguagccggccugagaggguguccggccacacugggacugagauacggcccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagcgacgccgcgugggggaugacggccuucggguuguaaaccucuuucaccaucgacgaagguccggguucucucggauugacgguagguggagaagaagcaccggccaacuacgugccagcagccncgguaauacguagggugcgagcguuguccggaauuacugggcguaaagagcucguaggugguuugucgcguuguucgugaaaucucacggcuuaacugugagcgugcgggcgauacgggcagacuagaguacugcaggggagacuggaauuccugguguagcgguggaaugcgcagauaucaggaggaacaccgguggcgaaggcgggucucugggcaguaacugacgcugaggagcgaaagcguggggagcgaacaggauuagauacccugguaguccacgccguaaacgguggguacuagguguggguuuccuuccuugggauccgugccguagcuaacgcauuaaguaccccgccuggggaguacggccgcaaggcuaaaacucaaaggaauugacgggggcccgcacaagcggcggagcauguggauuaauucgaunnaacgcgaagaaccuuaccuggguuugacaugcacaggacgcgucuagagauaggcguucccuuguggccugugugcagguggugcauggcugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuugucucauguugccagcacguaaugguggggacucgugagagacugccggggucaacucggaggaagguggggaugacgucaagucaucaugccccuuauguccagggcuucacacaugcuacaauggccgguacaaagggcugcgaugccgcgagguuaagcgaauccuuaaaagccggucucaguucggaucggggucugcaacucgaccccgugaagucggagucgcuaguaaucgcagaucagcaacgcugcggugaauacguucccgggccuuguacacaccgnccgucacgucaugaaagucgguaacacccgaagccaguggccuaacccucgggagggagcugucgaaggugggaucggcgauugggacgaagucgnaacaagguagccguaccggnnggugcggcuggauc ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<......<<<.<<<..<<<..<<....<<...<......>....>>...>>>>>......<<........<<<<<<<..<<...<<<<<<<<<<<<.....<<<<<......>>>>>......>>>>.....<<<<<<<<<<....>>>>>>>>>>...............>>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>...>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<<<<<<<......>>>>>>>.......>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<.....<<<<<<<.....>>>>>>>...>>>>>>>..>>>>>>>>>>...<<<<<<<<...<<<<<<<....<<..<<<<<..<<<......>>>.....>>>>>...>>..........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...........>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<...<<<<.<.<....>.>.>>>>.............>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<<..<<<......>>>>>.....>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<....<<<....>>>....>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<..<<<<....<.<<<<..<<<..<<<..>>>.>>>.>>>>.>...>>>>..>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>..... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(...(....(....).....).)..)))))......(((.......(((((((..((...(((.(((..(((......(((.(....).))).......))).......((((.((((....))).)))))......((......)).))).)))..))))))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).((((..............)))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(..(..((..........))..)..)....)))))....)).((((([[[...((((......((.]]]))........)))))))))..)))))))))..........((([[...(.((((....((.(((((((.(((((..(((.....(((((((.....)))))))...)).).)))..)))))))))..(((.(((((...(((((.((.......((((...((........))......)))).......).......((....))..))))))..)))))..))..)))....))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...........))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((.(..(((((((((.......((........))..........(((((((..(...((((.....(((.(.(....).).)))...............))))).((.(((...((((((.(....(((((((((....)))....((......).)...)))))).....((((.((((.((...((..(((......)))))....)).))))..(..(((.(.....).))).....)..)))).....).).)))...)).)))))....)))))))....).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..).))).....(((((((..........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(..(....((((....(.(((...(((..((....)).)))..))).)...))))....)..)..))).))))..).))...)..)..(((((.((......)).)))))}.... Mtb 70SIC in complex with MtbEttA at Trans_R1 state; 16S rRNA 7msz y 77 3.1 RF00005 URS000041AF00_83332 35064151 0030533 0006412 83332 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(((((.......)))))))))))..... Mtb 70SIC in complex with MtbEttA at Trans_R1 state; initiator tRNA (Met) 7mt2 A 3118 2.76 RF02540,RF02541,RF00002 URS00005E0FC6_83332 35064151 0003735 0005840 83332 aagugucuaagggcgcaugguggaugccuuggcaucgagagccgaugaaggacgugggaggcugcgauaugccucggggagcugucaaccgagcguggauccgaggauuuccgaauggggaaacccagcacgagugaugucgugcuacccgcaucugaauauauagggugcgggagggaacgcggggaagugaaacaucucaguacccguaggaggagaaaacaauugugauuccgcaaguaguggcgagcgaacgcggaacaggcuaaaccgcacgcauggguaaccggguagggguugugugugcgggguugugggaggauaugucucagcgcuacccggcugagaggcagucagaaagugucgugguuagcggaaguggccugggauggucugccguagacggugagagcccgguacgcgaaaacccggcaccugccuaguaucaauucccgaguagcagcgggcccguggaauccgcugugaauccgccgggaccacccgguaagccuaaauacuccucgaugaccgauagcggauuaguaccgugagggaauggugaaaaguaccccgggaggggagugaaagaguaccugaaaccgugugccuacaauccgucagagccuccuuuuccucuccggaggaggguggugauggcgugccuuuugaagaaugagccugcgagucagggacaugucgcaagguuaacccgugugggguagccgcagcgaaagcgagucugaauagggcgacccacacgcgcauacgcgcgugugaauaguggcguguucuggacccgaagcggagugaucuacccauggccagggugaagcgcggguaagaccgcguggaggcccgaacccacuuagguugaagacugaggggaugagcuguggguaggggugaaaggccaaucaaacuccgugauagcugguucuccccgaaaugcauuuaggugcagcguugcgugguucaccgcggagguagagcuacuggauggccgauggguuacugacgucagccaaacuccgaaugccgugguguaaagcguggcagugagacggcgggggauaagcuccguacgucgaaagggaaacagcccagaucgccggcuaaggcccccaagcgugugcuaagugggaaaggaugugcagucgcaaagacaaccaggagguuggcuuagaagcagccacccuugaaagagugcguaauagcucacuggucaagugauugugcgccgauaauguagcggggcucaagcacaccgccgaagccgcggcacauccaccuugugguggguguggguaggggagcgucccucauucagcgaagccaccgggugaccggugguggagggugggggagugagaaugcaggcaugaguagcgacaaggcaagugagaaccuugcccgccgaaagaccaaggguuccugggccaggccaguccgcccagggugagucgggaccuaaggcgaggccgacaggcguagucgauggacaacggguugauauucccguacccgugugugggcgcccgugacgaaucagcgguacuaaccacccaaaaccggaucgaucacuccccuucggggguguggaguucuggggcugcgugggaacuucgcugguaguagucaagcgaaggggugacgcaggaagguagccguaccagucagugguaacacuggggcaagccgguagggagagcgauaggcaaauccgucgcucacuaauccugagaggugacgcauagccgguugaggcgaauucggugauccucugcugccaagaaaagccucuagcgagcacacacacggcccguaccccaaaccgacacagguggucagguagagcauaccaaggcguacgagauaacuaugguuaaggaacucggcaaaaugcccccguaacuucgggagaagggggaccggaauaucgugaacacccuugcggugggagcgggauccggucgcagaaaccagugaggagcgacuguuuacuaaaaacacagguccgugcgaagucgcaagacgauguauacggacugacgccugcccggugcuggaagguuaagaggacccguuaacccgcaagggugaagcggagaauuuaagccccaguaaacggcggugguaacuauaaccauccuaagguagcgaaanuccuugucggguaaguuccgaccugcacgaauggcguaacgacuucucaacugucucaaccauagacucggcgaaauugcacuacgaguaaagaugcucguuacgcgcggcaggacgaaaagaccccgggaccuucacuacaacuugguauugauguucgguacgguuuguguaggauaggugggagacugugaaaccucgacgccaguuggggcggagucguuguugaaauaccacucugaucguauugggcaucuaaccucgaacccugaaucggguuuagggacagugccuggcggguaguuuaacugnggcgguugccuccuaaaauguaacggaggcgcccaaagguucccucaaccuggacggcaaucagguggcgaguguaaaugcacaagggagcuugacugcgagacuuacaagucaagcagggacgaaagucgggauuagugauccggcacccccgaguggaaggggugucgcucaacggauaaaagguaccccggggauaacaggcugaucuuccccaagaguccauaucgacgggaugguuuggcaccucgaugucggcucgucgcauccuggggcuggagcaggucccaaggguugggcunuucgcccauuaaagcggcacgcgagcuggguuuagaacgucgugagacaguucggucucuauccgccgcgcgcgucagaaacuugaggaaaccugucccuaguacgagaggaccgggacggacgaaccucuggugcaccaguugucccgccaggggcaccgcuggauagccacguucggucaggauaaccgcugaaagcaucuaagcgggaaaccuucuccaagaucagguuucucacccacuuggugggauaaggccccccgcagaacacggguucaauaggucagaccuggaagcucaguaauggguguagggaacuggugcuaaccggccgaaaacuu <<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<<......<<<<<<.[[.(((.>>>.....<<<<<<<..<<<)))..]].>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<<..>>>..<<<<<<.....<<.....>>....>>>>>>..<<<....<<<<<<<<<<......<<((((((>>...>>>>>>>>>>......<<<<<<<<<<..<<<<<<.)))))).>>>>>><<<<<<.......<<<<<<.<<<<.<<<.....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>>>.>>>>>..>>>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..>>>......>>.>>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>..<....<<<<..<<<.<<<.<.<.........>.>>>>.>>>..>>>>...<.<........>.>.<<<<<<....<<<.<<<<<<<<<<..<<<...<<<....>>>...>>>...<<....>>..<<<<.....>>>>.....<<<<<<........>>>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<....<<<<<<<<.....<<<....<<<.<<<<....<.....>....>>>>.>>>..>>.>.....>>>>>>>>....>>>>>>>.>>..<<<<<<<<<<......>>>>>>.>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..<.<.........>.>..>>>.........<<......>>...>>>>>....>>>>>>>>>.>>...........)))......>>>>>>.>>>...>>>>>>><<<<<<<<<<....>>>>>>>>>>....>>>>>>..<<<<<<<<<.......<<<<<<<<....>>>>>>>>....>>>>>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<.<<.....<<<<....<<<<<<......<<<<......<<<<<....<<<<.<<<......>>>.>>>>...>>>>>......>>>>.....>>>>>>......>>>>.<<..<<<<<<...<<<<..<<<..<<<<..<<<<<...((((...>>>>>.<<..<<<....<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>....>>>...>>...<<<......>>>.....>>>>...>>>...>>>>........>>>>>>.>>..>>.>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<...<<.....<..<<....>>..>......>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<..<<....<<<<<.<<<<....>>>>..>>>>>....>>..>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.((..<<<<<......))>>>>>>.<<<<<<<<.<<<.<<......<<<<<<<<<<..<<<<<..<<.<<<<<.<<<<<<<<<<<<<<<<.<.........<<.<<.................................................>>.>>>.>>>>>>>>>>>>>>>>...<<<.<<<<<<......>>>>>>>>>....>>>>>.>>...>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.<<..>>>>..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<.<<<<...<<.......>>...>>>>.>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>>>>>>>>>....<<<<<<<...<<<...<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))))>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>..>>>.......>>>>>>>..<<<<.....>>>>....<<<<.<<<<.......>>>>.....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>> (((.......((((((((((.....(((..(((((((((((((......((((((.[[.[[[.))).....((((((...(((]]]..]].)))......))))))...)))....(((....)))(((((((......))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((((((((((.....(([[[[[[))..)))))))))))....(.((((.(((((..((((((.]]]]]].))))))((((((.......((((((.((((.(((...(.((((......)))))[[(...).(((.....]])))...)))...)))))))))))))))).)))))...))))]....(((((((...[.......)))))))....).(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((..(((.(((.(.............)))).)))..)))).<.(.(........).).((((((..(.(((.((((((((((..(((...(((....)))...)))....(....)...((((.....))))......((...(......)...))......)))))))))))))..((.(...((((((.....(((((((((..((((...((((((......))))))...)[)))...(((.((((........A.)))))))....))))))))).(.(((.....)))...)..))))))......).))).(((((.....(((((....)))))(((((((((....((((((((.....(((....(((.((((....((..).)....)))).)))..)).).....))))))))....))))))).))..((((((((((......)))))).))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{...((..((....(...........)....)).....(...((......)).)..)).....)))))))))).))...........]]].)....))))))))))...)))))))((((((((((....)))))))))).....)))))(.((((((((((......((((((((....))))))))...))))))))))..).....))))))(......((.....((((((.......))))))((((....((((..((...((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(.(((........))).)]](((((((((.((.....((((....(((((..(....(((.......((..(......((.((((....)))).)).....)..)).......)))....).)))))......)))).((...(((((...((((..(((..((((..(((((....{{{...))))).((..(((....(((((((((((.((.....))))))))).....))))..[.)))...))...(((......))).....))))...)))...))))(..)....)))))..))..)).)))))))))))))..)).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.............((...]))...........))))))(...).......((((((((..].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((....((((..((((....))))...))))....))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))....).))))))).)..))).)))))))).)))))).....))[[..(((((.....>]])))))..((((((((.(((.((......(((((((.((..(((((..((.(((((.((((((((((((((((.(.........((.......................................................))).))))))))))))))))...(((.((((((......)))))))))....))))).))...)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......)).)..))))))......(((((.(.(.((((...((.......))...)))).)...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..a.))..)))))))))))[..<(((((((...(((...(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....)))..)))..]....)))))))..((((....>))))....((((.((((.......)))).....((((((((.(((....(((((....)))))...)))..))))).)))...)))).....))) Mtb 70S initiation complex; 23S rRNA 7mt2 B 115 2.76 RF00001 URS00005330B1_83332 35064151 0003735 0005840 83332 uuacggcggccacagcggcagggaaacgcccggucccauuccgaacccggaagcuaagccugccagcgccgaugauacugccccuccggguggaaaaguaggacaccgccgaaca <..<<<<<<.....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<.......<<<<<<....>>>>>>.......>>...>>>>>>.>.. ((.((((((.....((((((((.....((((((...(.....)...))))..))....)))))).)).((.......((((((....)))))).......))...)))))))).. Mtb 70S initiation complex; 5S rRNA 7mt2 a 1519 2.76 RF00177,RF01959,RF01960 URS00002C0A67_83332 35064151 0003735 0005840 83332 uggagaguuugauccuggcucaggacgaacgcuggcggcgugcuuaacacaugcaagucgaacggaaaggucucuucggagauacucgaguggcgaacgggugaguaacacgugggugaucugcccugcacuucgggauaagccugggaaacugggucuaauaccggauaggaccacgggaugcaugucuugugguggaaagcgcuuuagcggugugggaugagcccgcggccuaucagcuuguugguggggugacggccuaccaaggcgacgacggguagccggccugagaggguguccggccacacugggacugagauacggcccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagcgacgccgcgugggggaugacggccuucggguuguaaaccucuuucaccaucgacgaagguccggguucucucggauugacgguagguggagaagaagcaccggccaacuacgugccagcagccncgguaauacguagggugcgagcguuguccggaauuacugggcguaaagagcucguaggugguuugucgcguuguucgugaaaucucacggcuuaacugugagcgugcgggcgauacgggcagacuagaguacugcaggggagacuggaauuccugguguagcgguggaaugcgcagauaucaggaggaacaccgguggcgaaggcgggucucugggcaguaacugacgcugaggagcgaaagcguggggagcgaacaggauuagauacccugguaguccacgccguaaacgguggguacuagguguggguuuccuuccuugggauccgugccguagcuaacgcauuaaguaccccgccuggggaguacggccgcaaggcuaaaacucaaaggaauugacgggggcccgcacaagcggcggagcauguggauuaauucgaunnaacgcgaagaaccuuaccuggguuugacaugcacaggacgcgucuagagauaggcguucccuuguggccugugugcagguggugcauggcugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuugucucauguugccagcacguaaugguggggacucgugagagacugccggggucaacucggaggaagguggggaugacgucaagucaucaugccccuuauguccagggcuucacacaugcuacaauggccgguacaaagggcugcgaugccgcgagguuaagcgaauccuuaaaagccggucucaguucggaucggggucugcaacucgaccccgugaagucggagucgcuaguaaucgcagaucagcaacgcugcggugaauacguucccgggccuuguacacaccgnccgucacgucaugaaagucgguaacacccgaagccaguggccuaacccucgggagggagcugucgaaggugggaucggcgauugggacgaagucgnaacaagguagccguaccggnnggugcggcuggauc ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<..<<...<<....>>....>>>..>>>>>......<<........<<<<<<<..<<...<<<<<<<<<<<<.....<<<<<......>>>>>......>>>>.....<<<<<<<<<<....>>>>>>>>>>.....<<......>>>>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>...<.<<<<<......<<<<.<<.....>>..>>>>.......>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<.....<<<<<<<.....>>>>>>>...>>>>>>>..>>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<<..<<<......>>>.....>>>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<.........>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<.<.<....>.>.>>>............>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<...<<<......>>>.>.....>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<..<<<<....<.<<<<..<<<..<<<..>>>.>>>.>>>>.>...>>>>..>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((......((....)).....))..)))))......(((.......(((((((..((...(((.(((.((((.....((((((....))))))......))))......(((((((((....)))))))))......((......)).))).)))..))))))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(..((.(............).))..)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((.....(((((((.....)))))))...))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((..(......).))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...((((..(..(((.(.(....).).)))...........)...))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((......)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((..((((....(.((((..(((..((....)).))).)))).)...))))..))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Mtb 70S initiation complex; 16S rRNA 7mt2 y 77 2.76 RF00005 URS000041AF00_562 35064151 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(((((.......)))))))))))..... Mtb 70S initiation complex; initiator tRNA (Met) 7mt3 A 3118 2.8 RF02540,RF02541,RF00002 URS00005E0FC6_83332 35064151 0003735 0005840 83332 aagugucuaagggcgcaugguggaugccuuggcaucgagagccgaugaaggacgugggaggcugcgauaugccucggggagcugucaaccgagcguggauccgaggauuuccgaauggggaaacccagcacgagugaugucgugcuacccgcaucugaauauauagggugcgggagggaacgcggggaagugaaacaucucaguacccguaggaggagaaaacaauugugauuccgcaaguaguggcgagcgaacgcggaacaggcuaaaccgcacgcauggguaaccggguagggguugugugugcgggguugugggaggauaugucucagcgcuacccggcugagaggcagucagaaagugucgugguuagcggaaguggccugggauggucugccguagacggugagagcccgguacgcgaaaacccggcaccugccuaguaucaauucccgaguagcagcgggcccguggaauccgcugugaauccgccgggaccacccgguaagccuaaauacuccucgaugaccgauagcggauuaguaccgugagggaauggugaaaaguaccccgggaggggagugaaagaguaccugaaaccgugugccuacaauccgucagagccuccuuuuccucuccggaggaggguggugauggcgugccuuuugaagaaugagccugcgagucagggacaugucgcaagguuaacccgugugggguagccgcagcgaaagcgagucugaauagggcgacccacacgcgcauacgcgcgugugaauaguggcguguucuggacccgaagcggagugaucuacccauggccagggugaagcgcggguaagaccgcguggaggcccgaacccacuuagguugaagacugaggggaugagcuguggguaggggugaaaggccaaucaaacuccgugauagcugguucuccccgaaaugcauuuaggugcagcguugcgugguucaccgcggagguagagcuacuggauggccgauggguuacugacgucagccaaacuccgaaugccgugguguaaagcguggcagugagacggcgggggauaagcuccguacgucgaaagggaaacagcccagaucgccggcuaaggcccccaagcgugugcuaagugggaaaggaugugcagucgcaaagacaaccaggagguuggcuuagaagcagccacccuugaaagagugcguaauagcucacuggucaagugauugugcgccgauaauguagcggggcucaagcacaccgccgaagccgcggcacauccaccuugugguggguguggguaggggagcgucccucauucagcgaagccaccgggugaccggugguggagggugggggagugagaaugcaggcaugaguagcgacaaggcaagugagaaccuugcccgccgaaagaccaaggguuccugggccaggccaguccgcccagggugagucgggaccuaaggcgaggccgacaggcguagucgauggacaacggguugauauucccguacccgugugugggcgcccgugacgaaucagcgguacuaaccacccaaaaccggaucgaucacuccccuucggggguguggaguucuggggcugcgugggaacuucgcugguaguagucaagcgaaggggugacgcaggaagguagccguaccagucagugguaacacuggggcaagccgguagggagagcgauaggcaaauccgucgcucacuaauccugagaggugacgcauagccgguugaggcgaauucggugauccucugcugccaagaaaagccucuagcgagcacacacacggcccguaccccaaaccgacacagguggucagguagagcauaccaaggcguacgagauaacuaugguuaaggaacucggcaaaaugcccccguaacuucgggagaagggggaccggaauaucgugaacacccuugcggugggagcgggauccggucgcagaaaccagugaggagcgacuguuuacuaaaaacacagguccgugcgaagucgcaagacgauguauacggacugacgccugcccggugcuggaagguuaagaggacccguuaacccgcaagggugaagcggagaauuuaagccccaguaaacggcggugguaacuauaaccauccuaagguagcgaaanuccuugucggguaaguuccgaccugcacgaauggcguaacgacuucucaacugucucaaccauagacucggcgaaauugcacuacgaguaaagaugcucguuacgcgcggcaggacgaaaagaccccgggaccuucacuacaacuugguauugauguucgguacgguuuguguaggauaggugggagacugugaaaccucgacgccaguuggggcggagucguuguugaaauaccacucugaucguauugggcaucuaaccucgaacccugaaucggguuuagggacagugccuggcggguaguuuaacuggggcgguugccuccuaaaauguaacggaggcgcccaaagguucccucaaccuggacggcaaucagguggcgaguguaaaugcacaagggagcuugacugcgagacuuacaagucaagcagggacgaaagucgggauuagugauccggcacccccgaguggaaggggugucgcucaacggauaaaagguaccccggggauaacaggcugaucuuccccaagaguccauaucgacgggaugguuuggcaccucgaugucggcucgucgcauccuggggcuggagcaggucccaaggguugggcunuucgcccauuaaagcggcacgcgagcuggguuuagaacgucgugagacaguucggucucuauccgccgcgcgcgucagaaacuugaggaaaccugucccuaguacgagaggaccgggacggacgaaccucuggugcaccaguugucccgccaggggcaccgcuggauagccacguucggucaggauaaccgcugaaagcaucuaagcgggaaaccuucuccaagaucagguuucucacccacuuggugggauaaggccccccgcagaacacggguucaauaggucagaccuggaagcucaguaauggguguagggaacuggugcuaaccggccgaaaacuu <<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))...)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<<..>>>..<<<<<<.....<<.....>>....>>>>>>..<<<....<<<<<<<<<<......<<((((((>>...>>>>>>>>>>......<<<<<<<<<<..<<<<<<.)))))).>>>>>><<<<<<.......<<<<<<.<<<<.<<<.....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>>>.>>>>>..>>>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..>>>......>>.>>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<..<<<.<<<.<............>.>>>.>>>..>>>>...<.<........>.>.<<<<<<....<<<.<<<<<<<<<<..<<<...<<<....>>>...>>>...<<....>>..<<<<.....>>>>.....<<<..<<<....>>>..>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<....<<<<<<<<.....<<<....<<<.<<<<...............>>>>.>>>..>>.>.....>>>>>>>>....>>>>>>>.>>..<<<<<<<<<<......>>>>>>.>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<.....................>>.........<<......>>...>>>>>....>>>>>>>>>.>>...........)))......>>>>>>.>>>...>>>>>>><<<<<<<<<<....>>>>>>>>>>....>>>>>><.<<<<<<<<<.......<<<<<<<<....>>>>>>>>....>>>>>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<.<<.....<<<<...<..<<<..<....<<<<.<<...<<<<<.<..<<<<.<<<......>>>.>>>>.>.>>>>>...>>.>>>>....>.>>>..>.....>>>>.<<..<<<<<<...<<<<..<<<..<<<<..<<<<<...((((...>>>>>.<<..<<<....<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>....>>>...>>...<<<......>>>.....>>>>...>>>...>>>>........>>>>>>.>>..>>.>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<...<<.........................>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.<<<....<<<<..<<<<....>>>>...>>>>....>>>.>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.((..<<<<<......))>>>>>..<<<<<<<<.<<<.<<......<<<<<<<<<<..<<<<<..<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<.................................................>>>>>..>>>>>>>>>>>>>>>>...<<<.<<<<<<......>>>>>>>>>....>>>>>.>>...>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.<<..>>>>..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<.<<<<...<<.......>>...>>>>.>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>>>>>>>>>....<<<<<<<...<<<...<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<.)))).>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>..>>>.......>>>>>>>..<<<<.....>>>>....<<<<.<<<<.......>>>>.....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>> (((.......((((((((((.....(((..(((((((((((((......((((((.[[.[[[.))).....((((((...(((]]]..]].)))......))))))...)))....(((....)))(((((((......))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((((((((((.....(([[[[[[))..)))))))))))....(.((((.(((((..((((((.]]]]]].))))))((((((.......((((((.((((.(((...(.((((......)))))[[(...).(((.....]])))...)))...)))))))))))))))).)))))...))))]....(((((((...[.......)))))))....).(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((..(((.((((..............)))).)))..)))).<.(.(........).).((((((..(.(((.((((((((((..(((...(((....)))...)))....(....)...((((.....)))).....((....((....))....)).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.((((........A.)))))))..).))))))))).(.(((.....)))...)..))))))......).))).(((((.....(((((....)))))(((((((((....((((((((.....(((....(((.((((....(.()..)....)))).)))..)).).....))))))))....))))))).))..((((((((((......)))))).))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(.(.....{...(...((.....................)).....(...(.........))...).....).)..))))).))...........]]].)....))))))))))...)))))))((((((((((....)))))))))).....)))))(.((((((((((......((((((((....))))))))...))))))))))..).....))))))(......((.....((((((.......))))))((((.<..((((..((...((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(.(((........))).)]](((((((((.((.....(((.......(((..(.....(((.((....(.(.....((((.((((....)))).))))....).)....)).))).....).))).........))).((...(((((...((((..(((..((((..(((((....{{{...))))).((..(((....(((((((((((.((.....))))))))).....))))..[.)))...))...(((......))).....))))..>)))...))))(..)....)))))..))..)).)))))))))))))..)).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((..................].............))))))(...).......((((((((..].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((....((((..((((....))))...))))....))...))))))))..)))))(((.(.........).)))........((..........(((((.......)))))..)..)....))))....).))))))).)..))).)))))))).)))))).....))[[..(((((.....>]])))))..((((((((.(((.((......(((((((.((..(((((..((.(((((.(((((((.((((((((.(.........((.......................................................))).)))))))).)))))))...(((.((((((......)))))))))....))))).))...)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......)).)..))))))......(((((.(.(.((((...((.......))...)))).)...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..a.))..)))))))))))[..<(((((((...(((...(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....)))..)))..]....)))))))..((((....>))))....((((.((((.......)))).....((((((((.(((....(((((....)))))...)))..))))).)))...)))).....))) Mtb 70S with P/E tRNA; 23S rRNA 7mt3 B 115 2.8 RF00001 URS00005330B1_83332 35064151 0003735 0005840 83332 uuacggcggccacagcggcagggaaacgcccggucccauuccgaacccggaagcuaagccugccagcgccgaugauacugccccuccggguggaaaaguaggacaccgccgaaca <<.<<<<<<.....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<.......<<<<<<....>>>>>>.......>>...>>>>>>>>.. .(.((((((.....((((((((.....((((((...(.....)...))))..))....)))))).)).((.......((((((....)))))).......))...)))))).).. Mtb 70S with P/E tRNA; 5S rRNA 7mt3 a 1519 2.8 RF00177,RF01959,RF01960 URS00002C0A67_83332 35064151 0003735 0005840 83332 uggagaguuugauccuggcucaggacgaacgcuggcggcgugcuuaacacaugcaagucgaacggaaaggucucuucggagauacucgaguggcgaacgggugaguaacacgugggugaucugcccugcacuucgggauaagccugggaaacugggucuaauaccggauaggaccacgggaugcaugucuugugguggaaagcgcuuuagcggugugggaugagcccgcggccuaucagcuuguugguggggugacggccuaccaaggcgacgacggguagccggccugagaggguguccggccacacugggacugagauacggcccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagcgacgccgcgugggggaugacggccuucggguuguaaaccucuuucaccaucgacgaagguccggguucucucggauugacgguagguggagaagaagcaccggccaacuacgugccagcagccncgguaauacguagggugcgagcguuguccggaauuacugggcguaaagagcucguaggugguuugucgcguuguucgugaaaucucacggcuuaacugugagcgugcgggcgauacgggcagacuagaguacugcaggggagacuggaauuccugguguagcgguggaaugcgcagauaucaggaggaacaccgguggcgaaggcgggucucugggcaguaacugacgcugaggagcgaaagcguggggagcgaacaggauuagauacccugguaguccacgccguaaacgguggguacuagguguggguuuccuuccuugggauccgugccguagcuaacgcauuaaguaccccgccuggggaguacggccgcaaggcuaaaacucaaaggaauugacgggggcccgcacaagcggcggagcauguggauuaauucgaunnaacgcgaagaaccuuaccuggguuugacaugcacaggacgcgucuagagauaggcguucccuuguggccugugugcagguggugcauggcugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuugucucauguugccagcacguaaugguggggacucgugagagacugccggggucaacucggaggaagguggggaugacgucaagucaucaugccccuuauguccagggcuucacacaugcuacaauggccgguacaaagggcugcgaugccgcgagguuaagcgaauccuuaaaagccggucucaguucggaucggggucugcaacucgaccccgugaagucggagucgcuaguaaucgcagaucagcaacgcugcggugaauacguucccgggccuuguacacaccgnccgucacgucaugaaagucgguaacacccgaagccaguggccuaacccucgggagggagcugucgaaggugggaucggcgauugggacgaagucgnaacaagguagccguaccggnnggugcggcuggauc ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<..<<..<<<....>>>...>>>..>>>>>......<<........<<<<<<<..<<...<<<<<<<<<<<<.....<<<<<......>>>>>......>>>>.....<<<<<<<<<<....>>>>>>>>>>.....<<......>>>>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<<<<<<.......>.>>>>>.......>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<.....<<<<<<<.....>>>>>>>...>>>>>>>..>>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<<..<<<......>>>.....>>>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<.<........>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<...<<<.<.<....>.>.>>>.............>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<...<<........>>.>.....>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<..<<<<....<.<<<<..<<<..<<<..>>>.>>>.>>>>.>...>>>>..>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>..... ....((((..[.[[[..)))).((((.(((((..((((((.((....(((.(((..(((..((.((......((....)).....))..)))))......(((.......(((((((..((...(((.(((.((((.....((((((....))))))......))))......(((((((((....)))))))))......((......)).))).)))..))))))))).(((.....((..((((((((.......)))))))))).......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)..))))))..((((..(...((((....))))....)))))...(.(((((...(..(..((..........))..)..)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((.....(((((((.....)))))))...))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((.....(...).))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((.(..(((.(.(....).).)))..(......).)..)))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..((........))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(.(.((..((((....(.((((..(((..((....)).))).)))).)...))))..))..))..))).))))..).))...)..)..(((((((((....)))))))))}.... Mtb 70S with P/E tRNA; 16S rRNA 7mt3 y 77 2.8 RF00005 URS000041AF00_562 35064151 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(((((.......)))))))))))..... Mtb 70S with P/E tRNA; tRNA (Met) 7mt7 A 3118 2.71 RF02540,RF02541,RF00002 URS00005E0FC6_83332 35064151 0003735 0005840 83332 aagugucuaagggcgcaugguggaugccuuggcaucgagagccgaugaaggacgugggaggcugcgauaugccucggggagcugucaaccgagcguggauccgaggauuuccgaauggggaaacccagcacgagugaugucgugcuacccgcaucugaauauauagggugcgggagggaacgcggggaagugaaacaucucaguacccguaggaggagaaaacaauugugauuccgcaaguaguggcgagcgaacgcggaacaggcuaaaccgcacgcauggguaaccggguagggguugugugugcgggguugugggaggauaugucucagcgcuacccggcugagaggcagucagaaagugucgugguuagcggaaguggccugggauggucugccguagacggugagagcccgguacgcgaaaacccggcaccugccuaguaucaauucccgaguagcagcgggcccguggaauccgcugugaauccgccgggaccacccgguaagccuaaauacuccucgaugaccgauagcggauuaguaccgugagggaauggugaaaaguaccccgggaggggagugaaagaguaccugaaaccgugugccuacaauccgucagagccuccuuuuccucuccggaggaggguggugauggcgugccuuuugaagaaugagccugcgagucagggacaugucgcaagguuaacccgugugggguagccgcagcgaaagcgagucugaauagggcgacccacacgcgcauacgcgcgugugaauaguggcguguucuggacccgaagcggagugaucuacccauggccagggugaagcgcggguaagaccgcguggaggcccgaacccacuuagguugaagacugaggggaugagcuguggguaggggugaaaggccaaucaaacuccgugauagcugguucuccccgaaaugcauuuaggugcagcguugcgugguucaccgcggagguagagcuacuggauggccgauggguuacugacgucagccaaacuccgaaugccgugguguaaagcguggcagugagacggcgggggauaagcuccguacgucgaaagggaaacagcccagaucgccggcuaaggcccccaagcgugugcuaagugggaaaggaugugcagucgcaaagacaaccaggagguuggcuuagaagcagccacccuugaaagagugcguaauagcucacuggucaagugauugugcgccgauaauguagcggggcucaagcacaccgccgaagccgcggcacauccaccuugugguggguguggguaggggagcgucccucauucagcgaagccaccgggugaccggugguggagggugggggagugagaaugcaggcaugaguagcgacaaggcaagugagaaccuugcccgccgaaagaccaaggguuccugggccaggccaguccgcccagggugagucgggaccuaaggcgaggccgacaggcguagucgauggacaacggguugauauucccguacccgugugugggcgcccgugacgaaucagcgguacuaaccacccaaaaccggaucgaucacuccccuucggggguguggaguucuggggcugcgugggaacuucgcugguaguagucaagcgaaggggugacgcaggaagguagccguaccagucagugguaacacuggggcaagccgguagggagagcgauaggcaaauccgucgcucacuaauccugagaggugacgcauagccgguugaggcgaauucggugauccucugcugccaagaaaagccucuagcgagcacacacacggcccguaccccaaaccgacacagguggucagguagagcauaccaaggcguacgagauaacuaugguuaaggaacucggcaaaaugcccccguaacuucgggagaagggggaccggaauaucgugaacacccuugcggugggagcgggauccggucgcagaaaccagugaggagcgacuguuuacuaaaaacacagguccgugcgaagucgcaagacgauguauacggacugacgccugcccggugcuggaagguuaagaggacccguuaacccgcaagggugaagcggagaauuuaagccccaguaaacggcggugguaacuauaaccauccuaagguagcgaaanuccuugucggguaaguuccgaccugcacgaauggcguaacgacuucucaacugucucaaccauagacucggcgaaauugcacuacgaguaaagaugcucguuacgcgcggcaggacgaaaagaccccgggaccuucacuacaacuugguauugauguucgguacgguuuguguaggauaggugggagacugugaaaccucgacgccaguuggggcggagucguuguugaaauaccacucugaucguauugggcaucuaaccucgaacccugaaucggguuuagggacagugccuggcggguaguuuaacuggggcgguugccuccuaaaauguaacggaggcgcccaaagguucccucaaccuggacggcaaucagguggcgaguguaaaugcacaagggagcuugacugcgagacuuacaagucaagcagggacgaaagucgggauuagugauccggcacccccgaguggaaggggugucgcucaacggauaaaagguaccccggggauaacaggcugaucuuccccaagaguccauaucgacgggaugguuuggcaccucgaugucggcucgucgcauccuggggcuggagcaggucccaaggguugggcunuucgcccauuaaagcggcacgcgagcuggguuuagaacgucgugagacaguucggucucuauccgccgcgcgcgucagaaacuugaggaaaccugucccuaguacgagaggaccgggacggacgaaccucuggugcaccaguugucccgccaggggcaccgcuggauagccacguucggucaggauaaccgcugaaagcaucuaagcgggaaaccuucuccaagaucagguuucucacccacuuggugggauaaggccccccgcagaacacggguucaauaggucagaccuggaagcucaguaauggguguagggaacuggugcuaaccggccgaaaacuu 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(((.......((((((((((.....(((..(((((((((((((......((((((.[[.[[[.))).....((((((...(((]]]..]].)))......))))))...)))....(((....)))(((((((......))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((((((((((.....(([[[.[[))..)))))))))))....(.((((.(((((..((((((.]].]]].))))))((((((.......((((((.((((.(((...(.((((......)))))[[(...).(((.....]])))...)))...)))))))))))))))).)))))...))))]....(((((((...[.......)))))))....).(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((..(((.((((..((.....)..).)))).)))..)))).<.(.(........).).((((((....(((.((((((((((..(((...(((....)))...)))....(....)...((((.....)))).....((((..(......)..)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.((((........A.)))))))..).))))))))).(.(((.....)))...)..))))))......).))..(((((.....(((((....)))))(((((((((....((((((((.....(((....(((.((((....(.....)....)))).)))..)).).....))))))))....))))))).))..((((((((((......)))))).))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{..((((.((.....................)).........((......))...))))....)))))))))).))...........]]].)....))))))))))...)))))))((((((((((....)))))))))).....)))))(.((((((((((......((((((((....))))))))...))))))))))..).....))))))(......((.....((((((.......))))))((((....((((..((...((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(.(((........))).)]](((((((((.((.....((((........(..(.....((........(.(.....(.((.((((....)))).)).)....).)........)).....).)..........)))).((...(((((...((((..(((..((((..(((((....{{{...))))).((..(((....(((((((((((.((.....))))))))).....))))..[.)))...))...(((......))).....))))...)))...))))(..)....)))))..))..)).)))))))))))))..)).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((..................].............))))))(...).......((((((((..].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((....((((..((((....))))...))))....))...))))))))..)))))(((((.........)))))........((.(......).(((((.......)))))..)..)....))))....).))))))).)..))).)))))))).)))))).....))[[..(((((.....>]])))))..((((((((.(((.((......(((((((.((..(((((..((.(((((.((((((((((((((((.(.............(................(........).......................)....).))))))))))))))))...(((.((((((......)))))))))....))))).))...)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......)).)..))))))......(((((.(.(.((((...((.......))...)))).)...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..a.))..)))))))))))[..<(((((((...(((...(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....)))..)))..]....)))))))..((((....>))))....((((.((((.......)))).....((((((((.(((.....((((....))))....)))..))))).)))...)))).....))) Mtb 70S with P and E site tRNAs; 23S rRNA 7mt7 B 115 2.71 RF00001 URS00005330B1_83332 35064151 0003735 0005840 83332 uuacggcggccacagcggcagggaaacgcccggucccauuccgaacccggaagcuaagccugccagcgccgaugauacugccccuccggguggaaaaguaggacaccgccgaaca <<.<<<<<<.....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<.......<<<<<<....>>>>>>.......>>...>>>>>>>>.. ((.((((((.....((((((((.....((((((...(.....)...))))..))....)))))).)).((.......((((((....)))))).......))...)))))))).. Mtb 70S with P and E site tRNAs; 5S rRNA 7mt7 a 1519 2.71 RF00177,RF01959,RF01960 URS00002C0A67_83332 35064151 0003735 0005840 83332 uggagaguuugauccuggcucaggacgaacgcuggcggcgugcuuaacacaugcaagucgaacggaaaggucucuucggagauacucgaguggcgaacgggugaguaacacgugggugaucugcccugcacuucgggauaagccugggaaacugggucuaauaccggauaggaccacgggaugcaugucuugugguggaaagcgcuuuagcggugugggaugagcccgcggccuaucagcuuguugguggggugacggccuaccaaggcgacgacggguagccggccugagaggguguccggccacacugggacugagauacggcccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagcgacgccgcgugggggaugacggccuucggguuguaaaccucuuucaccaucgacgaagguccggguucucucggauugacgguagguggagaagaagcaccggccaacuacgugccagcagccncgguaauacguagggugcgagcguuguccggaauuacugggcguaaagagcucguaggugguuugucgcguuguucgugaaaucucacggcuuaacugugagcgugcgggcgauacgggcagacuagaguacugcaggggagacuggaauuccugguguagcgguggaaugcgcagauaucaggaggaacaccgguggcgaaggcgggucucugggcaguaacugacgcugaggagcgaaagcguggggagcgaacaggauuagauacccugguaguccacgccguaaacgguggguacuagguguggguuuccuuccuugggauccgugccguagcuaacgcauuaaguaccccgccuggggaguacggccgcaaggcuaaaacucaaaggaauugacgggggcccgcacaagcggcggagcauguggauuaauucgaunnaacgcgaagaaccuuaccuggguuugacaugcacaggacgcgucuagagauaggcguucccuuguggccugugugcagguggugcauggcugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuugucucauguugccagcacguaaugguggggacucgugagagacugccggggucaacucggaggaagguggggaugacgucaagucaucaugccccuuauguccagggcuucacacaugcuacaauggccgguacaaagggcugcgaugccgcgagguuaagcgaauccuuaaaagccggucucaguucggaucggggucugcaacucgaccccgugaagucggagucgcuaguaaucgcagaucagcaacgcugcggugaauacguucccgggccuuguacacaccgnccgucacgucaugaaagucgguaacacccgaagccaguggccuaacccucgggagggagcugucgaaggugggaucggcgauugggacgaagucgnaacaagguagccguaccggnnggugcggcuggauc ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<..<<...<......>....>>>..>>>>>......<<........<<<<<<<..<<...<<<<<<<<<<<<.....<<<<<......>>>>>......>>>>.....<<<<<<<<<<....>>>>>>>>>>.....<<......>>>>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<<<<<<<......>>>>>>>.......>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<.....<<<<<<<.....>>>>>>>...>>>>>>>..>>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<<..<<<......>>>.....>>>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<.........>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<...<<<.<.<....>.>.>>>.............>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<<..<<........>>>>.....>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<..<<<<....<.<<<<..<<<..<<....>>.>>>.>>>>.>...>>>>..>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(....(....).....)))..)))))......(((.......(((((((..((...(((.(((.((((.....((((((....))))))......))))......(((((((((....)))))))))......((......)).))).)))..))))))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(..((.((.(......).)).))..)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((.....(((((((.....)))))))...))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...........))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((.(..(((.(.(....).).)))...........)..)))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(..........)))....)))))))..(..(((.(.....).))).....)..)))).....).).)))...)).)))))....))))))))..)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((..........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((..((((....(.((((..(((..((....)).))).)))).)...))))..))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Mtb 70S with P and E site tRNAs; 16S rRNA 7mt7 x 77 2.71 RF00005 URS000041AF00_562 35064151 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).......(((..]....)))..))))))..... Mtb 70S with P and E site tRNAs; tRNA (Met) 7mt7 y 77 2.71 RF00005 URS000041AF00_562 35064151 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Mtb 70S with P and E site tRNAs; tRNA (Met) 7n0b T 20 3.9 URS0002311A09_2697049 34315827 2697049 augugauuuuaauagcuucu .................... .................... Cryo-EM structure of SARS-CoV-2 nsp10-nsp14 (WT)-RNA complex; RNA (5'-R(*AP*UP*GP*UP*GP*AP*UP*UP*UP*UP*AP*AP*UP*AP*GP*CP*UP*UP*CP*U)-3') 7n0b D 19 3.9 URS0002311973_2697049 34315827 2697049 agaagcuauuaaaaucacc ................... ................... Cryo-EM structure of SARS-CoV-2 nsp10-nsp14 (WT)-RNA complex; RNA (5'-R(*AP*GP*AP*AP*GP*CP*UP*AP*UP*UP*AP*AP*AP*AP*UP*CP*AP*CP*C)-3') 7n0c T 25 3.4 URS00023119C4_2697049 34315827 2697049 augugauuuuaauagcuucuuagga ......................... ......................... Cryo-EM structure of the monomeric form of SARS-CoV-2 nsp10-nsp14 (E191A)-RNA complex; RNA (25-MER) 7n0c D 24 3.4 URS0002311973_2697049 34315827 2697049 uccuaagaagcuauuaaaaucacc ........................ ........................ Cryo-EM structure of the monomeric form of SARS-CoV-2 nsp10-nsp14 (E191A)-RNA complex; RNA (24-MER) 7n0d T 19 2.5 URS000231198E_2697049 34315827 2697049 ggggaugugauuuuaauag ................... ................... Cryo-EM structure of the tetrameric form of SARS-CoV-2 nsp10-nsp14 (E191A)-RNA complex; RNA (5'-R(*GP*GP*GP*GP*AP*UP*GP*UP*GP*AP*UP*UP*UP*UP*AP*AP*UP*AP*G)-3') 7n0d K 14 2.5 URS00023119DA_2697049 34315827 2697049 cuauuaaaaucacc .............. .............. Cryo-EM structure of the tetrameric form of SARS-CoV-2 nsp10-nsp14 (E191A)-RNA complex; RNA (5'-R(*CP*UP*AP*UP*UP*AP*AP*AP*AP*UP*CP*AP*CP*C)-3') 7n0d I 19 2.5 URS000231198E_2697049 34315827 2697049 ggggaugugauuuuaauag ................... ................... Cryo-EM structure of the tetrameric form of SARS-CoV-2 nsp10-nsp14 (E191A)-RNA complex; RNA (5'-R(*GP*GP*GP*GP*AP*UP*GP*UP*GP*AP*UP*UP*UP*UP*AP*AP*UP*AP*G)-3') 7n0d L 14 2.5 URS00023119DA_2697049 34315827 2697049 cuauuaaaaucacc .............. .............. Cryo-EM structure of the tetrameric form of SARS-CoV-2 nsp10-nsp14 (E191A)-RNA complex; RNA (5'-R(*CP*UP*AP*UP*UP*AP*AP*AP*AP*UP*CP*AP*CP*C)-3') 7n1p 16 1542 2.33 RF00177,RF01959,RF01960 URS00000ABFE9_83333 34234344 0003735 0005840 83333 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggaucaccuccuua ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<..........>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<.<.<<<..>>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<.<......>.>>.>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.............. ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((((..(....)..)))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((..........)).)))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((.(((....))).)))...((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}............. Elongating 70S ribosome complex in a classical pre-translocation (PRE-C) conformation; 16S rRNA 7n1p mR 27 2.33 34234344 511693 ggacaaucgauguucaaagucuucaaa ........................... ........................... Elongating 70S ribosome complex in a classical pre-translocation (PRE-C) conformation; mRNA 7n1p 23 2904 2.33 RF02540,RF02541 URS0002311982_83333 34234344 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauuaagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccuu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<<.....>>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<..<<<............<<<<<..<<.......<<<<<<<<....>>>>>>>>....>>............>>>>>...>>>..>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>.. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((((((.....))))).))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((((.(.........(((((..(.(......((((((((....))))))))...).)............)))))).)))).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))).. Elongating 70S ribosome complex in a classical pre-translocation (PRE-C) conformation; 23S rRNA 7n1p 5 120 2.33 RF00001 URS0000049E57_83333 34234344 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Elongating 70S ribosome complex in a classical pre-translocation (PRE-C) conformation; 5S rRNA 7n1p Pt 76 2.33 RF00005 URS000042DDAB_83333 34234344 0030533 0006412 83333 gggucguuagcucagnnggnagagcaguugacunuunaucaauuggncgcaggnucgaauccugcacgacccacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((.........)))).....(((((..]....)))))))))))).... Elongating 70S ribosome complex in a classical pre-translocation (PRE-C) conformation; tRNA 7n1p Dt 76 2.33 RF00005 URS00005AA258_83333 34234344 0030533 0006412 83333 gcccgganagcucagncgguagagcaggggauugaanauccccgunnccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((.........)))).....(((((..]....)))))))))))).... Elongating 70S ribosome complex in a classical pre-translocation (PRE-C) conformation; tRNA 7n2c 16 1534 2.72 RF00177,RF01959,RF01960 URS000081169C_83333 34234344 0003735 0005840 83333 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<............>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..........>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>..<<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>>.<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<<..>>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((.((..(......)..))..)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((.(....).))))......)).).....(((....)))....((((((..........)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))...((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Elongating 70S ribosome complex in a fusidic acid-stalled intermediate state of translocation bound to EF-G(GDP) (INT2); 16S rRNA 7n2c mR 12 2.72 URS0002311A38_83333 34234344 83333 uguucaaagucu ............ ............ Elongating 70S ribosome complex in a fusidic acid-stalled intermediate state of translocation bound to EF-G(GDP) (INT2); Chains: mR 7n2c 23 2903 2.72 RF02540,RF02541 URS00004B0F34_83333 34234344 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<<..>>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<.......>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<<..<<<<.......>>>>..>>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<......>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<......>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<<.<<....>>..>>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>...>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((........)))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((..((.......))...))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((((........)))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]]((((((..(((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((........)))...))))))...)))...))))(..).....))))...))....)))..)))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((((.(.....[...(((((..(((......((((((((....))))))))...)))..].........)))))).)))).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Elongating 70S ribosome complex in a fusidic acid-stalled intermediate state of translocation bound to EF-G(GDP) (INT2); 23S rRNA 7n2c 5 120 2.72 RF00001 URS0000049E57_83333 34234344 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Elongating 70S ribosome complex in a fusidic acid-stalled intermediate state of translocation bound to EF-G(GDP) (INT2); 5S rRNA 7n2c Pt 76 2.72 RF00005 URS000042DDAB_562 34234344 0030533 0006412 562 gggucguuagcucagnnggnagagcaguugacunuunaucaauuggncgcaggnucgaauccugcacgacccacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((.........)))).....(((((..]....)))))))))))).... Elongating 70S ribosome complex in a fusidic acid-stalled intermediate state of translocation bound to EF-G(GDP) (INT2); Chains: Pt 7n2c Dt 76 2.72 RF00005 URS0002311A2F_562 34234344 0030533 0006412 562 gcccgganagcucaguugggagagcaggggauugaanauccccgunnccuugguucgaucccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((.........)))).....(((((..]....)))))))))))).... Elongating 70S ribosome complex in a fusidic acid-stalled intermediate state of translocation bound to EF-G(GDP) (INT2); tRNA 7n2u 16 1534 2.53 RF00177,RF01959,RF01960 URS000081169C_83333 34234344 0003735 0005840 83333 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<..........>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((...(....)...))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))....(.....)..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Elongating 70S ribosome complex in a hybrid-H1 pre-translocation (PRE-H1) conformation; 16S rRNA 7n2u mR 11 2.53 34234344 511693 auguucaaagu ........... ........... Elongating 70S ribosome complex in a hybrid-H1 pre-translocation (PRE-H1) conformation; mRNA 7n2u 23 2902 2.53 RF02540,RF02541 URS00004B0F34_83333 34234344 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaacc <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<<.....>>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<<.<<....>>..>>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>...>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>> ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((((((.....))))).))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(.(.((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((.(((.((((.(.........(((((..(((......((((((((....))))))))...)))............)))))).)))).))).)))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))) Elongating 70S ribosome complex in a hybrid-H1 pre-translocation (PRE-H1) conformation; 23S rRNA 7n2u 5 120 2.53 RF00001 URS0000049E57_83333 34234344 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Elongating 70S ribosome complex in a hybrid-H1 pre-translocation (PRE-H1) conformation; 5S rRNA 7n2u Pt 76 2.53 RF00005 URS000042DDAB_83333 34234344 0030533 0006412 83333 gggucguuagcucagnngguagagcaguugacunuunaucaauugnncgcaggnucgaauccugcacgacccacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((.........)))).....(((((..]....)))))))))))).... Elongating 70S ribosome complex in a hybrid-H1 pre-translocation (PRE-H1) conformation; tRNA 7n2u Dt 76 2.53 RF00005 URS0002311A2F_83333 34234344 0030533 0006412 83333 gcccgganagcucaguugggagagcaggggauugaanauccccgunnccuugguucgaucccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((.........)))).....(((((..]....)))))))))))).... Elongating 70S ribosome complex in a hybrid-H1 pre-translocation (PRE-H1) conformation; tRNA 7n2v 16 1534 2.54 RF00177,RF01959,RF01960 URS000081169C_83333 34234344 0003735 0005840 83333 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<.<........>.>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<<..>>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((.(........).))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((...(....).)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....(((.((((.......)))).))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))...((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Elongating 70S ribosome complex in a spectinomycin-stalled intermediate state of translocation bound to EF-G in an active, GTP conformation (INT1); 16S rRNA 7n2v mR 12 2.54 34234344 511693 auguucaaaguc ............ ............ Elongating 70S ribosome complex in a spectinomycin-stalled intermediate state of translocation bound to EF-G in an active, GTP conformation (INT1); mRNA 7n2v 23 2904 2.54 RF02540,RF02541 URS00004B0F34_83333 34234344 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccuu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<.<<.......>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<......>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<<..>>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<....<....>.....>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<<.<<....>>..>>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>...>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>.. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((.(((.......)))..))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(...((......)).).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((((.(.....[...(((((..(((......((((((((....))))))))...)))..].........)))))).)))).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...((((.((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)).))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))).. Elongating 70S ribosome complex in a spectinomycin-stalled intermediate state of translocation bound to EF-G in an active, GTP conformation (INT1); 23S rRNA 7n2v 5 120 2.54 RF00001 URS0000049E57_83333 34234344 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Elongating 70S ribosome complex in a spectinomycin-stalled intermediate state of translocation bound to EF-G in an active, GTP conformation (INT1); 5S rRNA 7n2v Pt 76 2.54 RF00005 URS00023119DE_83333 34234344 0030533 0006412 83333 gggucguuagcucaguugguagagcaguugacunuunaucaauugnncgcagguucgaauccugcacgacccacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..(((......[...)))(((((.........)))))....(((((..]....)))))))))))).... Elongating 70S ribosome complex in a spectinomycin-stalled intermediate state of translocation bound to EF-G in an active, GTP conformation (INT1); tRNA 7n2v Dt 76 2.54 RF00005 URS000231196E_83333 34234344 0030533 0006412 83333 gcccgganagcucaguugggagagcaggggauugaanauccccgunnccuugguucgaucccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((.........)))).....(((((..]....)))))))))))).... Elongating 70S ribosome complex in a spectinomycin-stalled intermediate state of translocation bound to EF-G in an active, GTP conformation (INT1); tRNA 7n30 16 1526 2.66 RF00177,RF01959,RF01960 URS000081169C_83333 34234344 0003735 0005840 83333 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<...<<<<<<<..>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<..<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>.........>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((....))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))...((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Elongating 70S ribosome complex in a hybrid-H2* pre-translocation (PRE-H2*) conformation; 16S rRNA 7n30 mR 11 2.66 34234344 511693 auguucaaagu ........... ........... Elongating 70S ribosome complex in a hybrid-H2* pre-translocation (PRE-H2*) conformation; mRNA 7n30 23 2901 2.66 RF02540,RF02541 URS00004B0F34_83333 34234344 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaacc <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<<.....>>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<......<<<.........>>>.............<<......>>...>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<<.<<....>>..>>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>...>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>> ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((.((((.....))))..))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(....(((.........))).....)...(...((......)).).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((.(.(.........(((((..(((.......(((((((....)))))))....)))............)))))).).)).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))) Elongating 70S ribosome complex in a hybrid-H2* pre-translocation (PRE-H2*) conformation; 23S rRNA 7n30 5 120 2.66 RF00001 URS0000049E57_83333 34234344 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Elongating 70S ribosome complex in a hybrid-H2* pre-translocation (PRE-H2*) conformation; 5S rRNA 7n30 Pt 76 2.66 RF00005 URS000042DDAB_83333 34234344 0030533 0006412 83333 gggucguuagcucagnnggnagagcaguugacunuunaucaauugnncgcaggnucgaauccugcacgacccacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<..<.......>..>>>>>>>>>.... (((((((..((((..[..[..)))).((((.........)))).....(...(..]..].)...)))))))).... Elongating 70S ribosome complex in a hybrid-H2* pre-translocation (PRE-H2*) conformation; tRNA 7n30 Dt 76 2.66 RF00005 URS0002311A2F_83333 34234344 0030533 0006412 83333 gcccgganagcucaguugggagagcaggggauugaanauccccgunnccuugguucgaucccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((.........)))).....(((((..]....)))))))))))).... Elongating 70S ribosome complex in a hybrid-H2* pre-translocation (PRE-H2*) conformation; tRNA 7n31 16 1533 2.69 RF00177,RF01959,RF01960 URS000081169C_83333 34234344 0003735 0005840 83333 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauc ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<..........>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((((..........)))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))...((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Elongating 70S ribosome complex in a post-translocation (POST) conformation; 16S rRNA 7n31 mR 12 2.69 34234344 511693 guucaaagucuu ............ ............ Elongating 70S ribosome complex in a post-translocation (POST) conformation; mRNA 7n31 23 2904 2.69 RF02540,RF02541 URS00004B0F34_83333 34234344 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccuu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<<.....>>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<....<...........>....>>.....<...<<......>>.>.>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<<.<<....>>..>>>>>>..>....>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>.. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((((((.....))))).))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((....................................(......)....)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..((((......))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((((.(.........(((((..((.......((((((((....))))))))....))............)))))).)))).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))).. Elongating 70S ribosome complex in a post-translocation (POST) conformation; 23S rRNA 7n31 5 120 2.69 RF00001 URS0000049E57_83333 34234344 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Elongating 70S ribosome complex in a post-translocation (POST) conformation; 5S rRNA 7n31 Pt 76 2.69 RF00005 URS000042DDAB_83333 34234344 0030533 0006412 83333 gggucguuagcucagnngguagagcaguugacunuunaucaauugnncgcaggnucgaauccugcacgacccacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((.........)))).....(((((..]....)))))))))))).... Elongating 70S ribosome complex in a post-translocation (POST) conformation; tRNA 7n31 Dt 76 2.69 RF00005 URS00005AA258_83333 34234344 0030533 0006412 83333 gcccgganagcucagncgguagagcaggggauugaanauccccgunnccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((.........)))).....(((((..]....)))))))))))).... Elongating 70S ribosome complex in a post-translocation (POST) conformation; tRNA 7n8b A1 3156 3.05 RF02540,RF02543 URS00023358ED_4932 35489333 0003735 0005840 4932 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaugguguuuuguauuucacuggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugnaacnnggaccaaggagunuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccnanagauggugancuaugccugaauagggugaagccagaggaaacucugguggaggcucguancgguucugncgugcaaaucgaucgucgaaunuggguauagnggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcngaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaunuuggugguagunncaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaanguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauunaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugccnagugcucugaaugucaaagugangaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagcnannugccucnucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugunccuaucuacnaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcungacncuaguuugacauugugaagagacauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcugnggcggcacaucugunaaacgnuaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauunucagngugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuanangugccagaaaaguuaccacagngauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuungaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggaunnuucacccacuaauagggaacgugngnuggguuuagancgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>...<.....<<....>>..<<<<<......<<.....>>.....>>>>>..<<<...........<<.<<<<<<...>>>>>>.>>.............<<<<<<.<<<<<.<<.<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>......>>>>>>>>>>>........<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>....>.............................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<.<.......................<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<........>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<.................>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.........<<<..........................................>>>.....>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<............>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<......<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..[[[..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>............>>.>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<...............>>>>><<.<<<<<<<<<<<....>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<...<<.....<<<<....>>>>.....>>.>>>>>..>>>>><<<<...........>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<..<<<<<.............>>>>>...<<<<<.....<<<<..<<<..........>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))......<<<<<<<..<<<<.))))))>>>>>>>>>>>.........>>>>..>>>>>>.......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<<]]].>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((..(((..(..((((.(((((((...({((((......)))))[[(...).(((....}]])))....)))))))...)))).).......))).))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((........................(((((((((((((((((((((((.......(((((((......(((..........))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))).((((((......(((....)))..((((((((((...(((.(((((((.....(((....(((..(.(((.................))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(.(((........(.........)......(...(........).).))).)...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...((((((...((.....)).))))))....[[(((.((...((....(((....))).........((.(.(.....)..).)).....))....))...(((((........)))))]]((((..(((((.....((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))....(((((....(((((.....(((.....))).....))))).....))))).....(((((((......))))))))))).).))))))).))))(...)....))))))...)).......)).))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((.((....)).))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(.(.(((..((((((.(...((.....(((......))).....)).)))))..)))))(((.............)))........((..........(((((.......)))))..)..)....).)....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((.............)))))....((((.....((((...((..........))............>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((.(......(....).....).))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(((.((..)..).)))..)))))...)))....)))).)))))).))))).. Cycloheximide bound vacant 80S structure isolated from cbf5-D95A; 25S 7n8b A3 121 3.05 RF00001 URS000055688D_4932 35489333 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Cycloheximide bound vacant 80S structure isolated from cbf5-D95A; 5S 7n8b A4 158 3.05 RF00002 URS00001BF64E_4932 35489333 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Cycloheximide bound vacant 80S structure isolated from cbf5-D95A; 5.8S 7n8b B5 1783 3.05 RF01960,RF01959,RF00177 URS00023358D9_4932 35489333 0003735 0005840 4932 uaucugguugauccugccaguagucaunugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucnuuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauncaaggnaggcagcaggcgcgcnaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggnacaauuggagggcaagucugnugccagcagccgcggnaauuccagcuccaauagcguauauuaaaguuguugcaguunaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauungcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagancgaaaguuaggggaucgaagaugaucagauacngucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaangcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacncaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuuguggguggngnugcauggcnguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacangucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacnagnaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgnccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuucnguaggugnnccugcggaaggaucauua ...<<<<<.{.((((>>>>><<<<.<<<<<<...<.<...<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<..<<..<<....<<<..................<.....<<.<<<.....>>>.>>......>.........<<<<<............>>>>><...<<<<<<......(((.{.{.<<......>>....<<......>>>>>>>>.....>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>..>>>..>....>.>.....<<<.<<<................>>>..>>>......<<..<...........>..>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>>>>>.........<<<[[.....<.<<...<<<.<<....<<<<<<.<<<<..............>>>>.>>>>>>......<<<<...............................>>>>.....<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........<<<..<<<<<<<<.....}..}))).>>>>>>>>.>>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..]]>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..)))).}<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<.....<..<<.<<<........>>>>>..>....>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<.<<<<<..>>>>>.>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<..<....................>.>.>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((............)))))(.(.((((((......[[[.[.[.(........).....(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(....(.....(......).....).....)......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.((.(......()......).)).)))))).......((.................................))......(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(((..(.((.(((.....]..]]]].))).)).).))).....))...(((.(((.((...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)).)))..))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((........(...((........))..).......)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..(((...(((((..(.((((..)))).)....)))))...))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((.(((..........))).))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...((((....(....................)....))))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>........ Cycloheximide bound vacant 80S structure isolated from cbf5-D95A; 18S RIBOSOMAL RNA 7nac 1 2661 3.04 RF02543 URS000261776E_1247190 36482249 0003735 0005840 1247190 guuugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaugguguuuugugcccucugcuccuuguggguaggggaaucucgcauuucacugggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucggcggucgaucgucgaauuuggguauaggggcgaaagacaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugaauguaagaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacuucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucgguccguaacuucgggauaaggauuggcucuaagggucggguagugagggccuuggucacggccuuggcuugcuacaauuaacgaucaacuuagaacugguacggacaaggggaaucugacuguuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaacccuguugagcuugacucuaguuugacauugugaagagacauagaggguguagaauaagugggagcuucggcgccagugaaauaccacuaccuuuauaguuucuuuacuauugucagguggggaguaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcucggcucuuccuaucauaccgaagcagaauucgguaagcguuggaunnuucacccacuaauagggaacgugngcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccguuacgaucugcugagauuaagccuuuguugucugauuugu ..........................<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..<<<..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<<.<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....<<<<<<..>>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<.....<<<<<....<<..<<<<<<<<<.....>>>>>>>>>......>>....>>>>>.<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<......>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<.<<<<<.......>>>.>>..>>....>>>>>>.>>>>>>..<<.<...<<<<<<...<<<<<<<<<<...<<<....<<<<<<<....>>>>>>>.....>>>.<<<<....>>>>.....>>>>>>>>>>...<....>...>>>>>>......>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<....>>>>.>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>>..<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<......<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..(((..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>............>>.>>>>>>>>>>>>..>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<........<<<<<<.<<<<.....................<<<<<.<<<<<<<<..<<..<<<<..>>>>..>>>>>>>>>>......>>>>>......>>>...>>>>>>>....<<<<<<<<<........>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<..<<<<<<.<<<<<<..<<<<.<<<<.<<...<<<<<<<<<<..<<<.<..........<<<<<..<<<..>>>............>>>>>..>>>>...>>>>>>>>>>....>>.>>>>..>>>>..>>>>>.>.>>>>>>.............<<<<<<...<<.......>>...>>>>>>.......<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>.................<<<<<<<....>>>.>>>>........>>>.>>>>>....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<....<<<<<<<<<<))).>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<.......>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ..........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........(((((((.((((((.(((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))).))....)))))))))))...)....(((((((........))))))).....((((((..))))))..)))..................................((....))............(..((((....))))............).....................(((((.(((((......(((.....(....((((.(..((.).).).))))..........)...)))..(((((((((((((((((((((((.......(((((((......((((........)))).......))))))).....))))).))))))))))........(((....)))....)))))))).....))))).)))))..((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).(((...((.......))....).))....)))))).))))))..((.(...((((((....(((((((((...(((....(((((((....))))))).....)))..((.(..).))......)))))))))..(.(....).).))))))......).))).((((((......(((....)))..((((((((((....((.(((((((..))))).))))..)))))))).))..((((.((.((.....)).)).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((.((....((.........))....)).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....(((((.((...((((((...((.....)).))))))....[[(((.((...((....(((....)))........((((((........))))))....))....))...(((((........)))))]]((((..(((((.....((((....)))...(...((((((...((((.((((((((((((((((((..[[[..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...)).......)).))).)))).)))..))))))).((((.....))))..))))..((((.....(((((((.((..(....((.((((.(.((.....................(((((.(((((.((..((..((((..))))..)))).)))))......)))))......))...).)))).)....(((((((((........)).))))))).)..))).)))))))..))))))....)).[..(((((......].)))))....(((((..(((..((((((.((((((..((((.(..(......(...((((.((.(.(.((..........((((..((....))............))))..))).).).).))).)..)........).)..))))..))))).).)))))).............((((((...((.......))...))))))...(..(((((..(.(((((((......))))))..).).(((.........))).....)))))......).........(((.(((....)))..)))........))).)))))....((((((((..((((.(..((((......(....).....))))..)(((((...((((....((((((((((]]].)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((....((.......))...))))...)))....)))).)))))).))))).. State E2 nucleolar 60S ribosomal biogenesis intermediate - Composite model; 25S rRNA 7nac 2 158 3.04 RF00002 URS00001BF64E_1247190 36482249 0003735 0005840 1247190 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... State E2 nucleolar 60S ribosomal biogenesis intermediate - Composite model; 5.8S rRNA 7nac 6 87 3.04 URS000261775E_1247190 36482249 1247190 ccuucucaaacauucuguuugguagugagugauacucuuuggaguuaacuugaaauugcuggccuuuaggcgaacaauguucuuaaa ......<<<<<<...>>>>>>.....<<<<...<<<<....>>>>..>>>>..........<<<<..>>>>................ ......((((((...))))))....(((((...((((....))))..))))..).......((((..))))................ State E2 nucleolar 60S ribosomal biogenesis intermediate - Composite model; 5.8S ribosomal RNA gene and internal transcribed spacer 2 7nad 1 697 3.04 RF02543 URS000261777B_1247190 36482249 0003735 0005840 1247190 augccugaauagggugaagccagaggaaacucugguggaggcucgcgaauuuggguauaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagaugguuucaaaggccugacaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugucuccaaggugaacagccucuaguugauagaagauaagggaagucgguccguaacuucgggauaaggauuggcucuaagggucggguagugagggccuuggucacggccuuggcuugcuacaauuaacgaucaacuuagaacugguacggacaaggggaaucugacuguuaacgagauucccacugucccuaucuacuaucuagcgaggcugucugaucaggcauugcguaagcaguagaguagccguuacgaucugcugaga <<<<<<<<...<<<....<<<<<<<....>>>>>>>.....>>>......>>>>>>>>....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<............<<<<<<.>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<......<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..(((..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>............>>.>>>>>>>>>>>>..>>.>>>>>.<<<<.....>>>>..>>>>..<<<<.<<<<.<<........<<<<<<.<<<<.....................<<<<<.<<<<<<<<..<<..<<<<..>>>>..>>>>>>>>>>......>>>>>......>>>...>>>>>>>....<<<<<<<<<........>>.>>>>>>>.....>>.>>>>.....>>>>>>...<<<<<<<))).>>>>>..>>....<<<<....<<.......>>...>>>>..... ((((((((...((((...(((((((....)))))))...).)))......))))))))....((.....((((((.......))))))((((.....(((((.((.(.((((((...((.....)).)))))))...[[(((.((...((............((((((.))))))....))....))...(((((........)))))]]((((..(((((.....((((....)))...(...((((((...((((.((((((((((((((((((..[[[..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...)).......)).))).)))).)))..)).))))).((((.....))))..))))..((((.((((.((.......((.((((.(.((.....................(((((.((((.(((..((..((.(..).))..))))).))))......)))))......))...).)))).)....(((((((((........)).))))))).)...)).)))).....))))))...(((((((]]].)))))..))....((((....((.((.)).))...))))..... State E2 nucleolar 60S ribosomal biogenesis intermediate - Spb4 local refinement model; 25S rRNA 7nad 2 59 3.04 RF00002 URS0002617755_1247190 36482249 0003735 0005840 1247190 gaacgcgcgauacucuuugaacgcacauugcgccccuugguauuccagggggcaagcgu <<<<<..>>......>>>....<<.....>><<<<<<<<<....>>>>>>>>>...... (((((()))......)))....((.....))(((((((((....)))))))))...... State E2 nucleolar 60S ribosomal biogenesis intermediate - Spb4 local refinement model; 5.8S rRNA 7nbu A 1539 3.11 RF00177,RF01959,RF01960 URS00023358EE_562 35552387 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacagaacuuuccagagauggauuggugccuucgggaacugugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuaucuuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<.<<<<..........>>>>..>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<..<<<<....>>>>..>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((.(((............)))..))))..)))))......(((......(((((((..((...((((.((.(.((.....((((.(....).))))......)).).....(((....)))....(((.((..((....)))).))).)).))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....(.(((.((.......)).))).).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(..((((....))))..)....(....)...))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.((.((((...((..(.(......))))....)))).))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Structure of the HigB1 toxin mutant K95A from Mycobacterium tuberculosis (Rv1955) and its target, the cspA mRNA, on the E. coli Ribosome.; 16S ribosomal RNA 7nbu V 77 3.11 RF00005 URS00001BBAFC_83333 35552387 0030533 0006412 83333 cgcggggnggagcagccuggnagcucgucgggcucauaacccgaagaucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Structure of the HigB1 toxin mutant K95A from Mycobacterium tuberculosis (Rv1955) and its target, the cspA mRNA, on the E. coli Ribosome.; P-site fMet-tRNA(fMet) 7nbu X 10 3.11 35552387 83332 aauaugccac .......... .......... Structure of the HigB1 toxin mutant K95A from Mycobacterium tuberculosis (Rv1955) and its target, the cspA mRNA, on the E. coli Ribosome.; cspA mRNA 7nbu a 2900 3.11 RF02540,RF02541 URS000024A55C_83333 35552387 0003735 0005840 83333 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(.((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((........((.((((((((.(((...(((((......)))))[[......(((.....]])))...)))...)))))))).)).....))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((.((....)).)))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))..(((((((..((((((((((.....(((...(((.((((...((.............))...)))).)))..)).).....)))))).)))..)))))))).....(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{..((..((.........................).......(.........)..).))....)))..))))).))...........]]].)...))))))))))...)))))))((((((..........))))))....))))))(.(((((....((......((((((((....))))))))...))...)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..((((......))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((((..(..........................(.............(......)...........)..........................)..))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....((((((..((..]]]]..)).)))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))).). Structure of the HigB1 toxin mutant K95A from Mycobacterium tuberculosis (Rv1955) and its target, the cspA mRNA, on the E. coli Ribosome.; 23S ribosomal RNA 7nbu b 120 3.11 RF00001 URS0000049E57_83333 35552387 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Structure of the HigB1 toxin mutant K95A from Mycobacterium tuberculosis (Rv1955) and its target, the cspA mRNA, on the E. coli Ribosome.; 5S ribosomal RNA 7nfx 5 3493 3.2 RF02540,RF02543 URS00023119A2_9986 34020957 0003735 0005840 9986 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.........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..(((((((((((.....)))))).))))....))))....((((((.((....((((((((.(.(....((((((((..({((((......)))))....[[(...).(((....}]])))...).)))))))).)))))))))...)).))))))..)....(((.(((........))).))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((......((((((((.....(((((((((((...(((.(..(((((.((..)))).)))..)...))).)))))))))))..........))).)))))..((((((((.((((.(((((.(((....(...(.((((.((((......(((((()))))).......)))).))))).........).)))...))))).))))....................(((((..((((((...))))))..((..(.((((..(((((((((((((((((((((((.((((....)))).)))))))))).))))))))))).))....).)))...).)..)......)))))......))).)))))....)))...)))))))).[((((........))))((((((....(((((((((((((..(((..(((((........)))).)...)))...((....))...((((((((....))))))))..(((((...(((..(((...[[[...[.)))..)))....))))).(((((((((.((((......))))))))))).))....)))))))))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((..........(.(.((((((....(((....(((..(.(((..((((.(.(.....).).))))))).)..)))..)).)....))))))...(((((((((........)))))))))....).).)))))))..))..((((.((.((.....)).)).))))....(((......)))...(((((((...((([[[.....(.(((((......(..........(((.((((((((.(..........).)))))))))))..........]]].)....)))))).)))...)))))))((((((.(((...........]..]]]..............................)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...((..(.(((....))).....)....((.((((.(.((...)).).))))))......))....))...(((((........)))))]]((((....(((.....(((((((....)))))))..((((....)))...(...((((((...(((((((((((((((((.((((....{{..).))).....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...))............))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((...((((((.))))))........)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))..(((.........)))..........((.(......).(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.(((((((((.((((((((((..))))))))))...(((((.....((((..(..().)..............(((((((((((.....)))))))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(.((((.......).)))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a.))..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}..)))))..)).))...))))...)))).((((...((((.............))))...))))..)))...).))))))......(((((..(...(((.....((..........((((..((((())))).)))).........))....((..((((....((((.(((((((......)))))))))))...))))..))..............)))...).))))).(((((.(..(.......)..)....((.(((((((.((.....((((.(..(((((......)))))..)))))....))....)))).))).))..))))).. Mammalian ribosome nascent chain complex with SRP and SRP receptor in early state A; 28S ribosomal RNA 7nfx 7 120 3.2 RF00001 URS000002B0D5_9986 34020957 0003735 0005840 9986 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. Mammalian ribosome nascent chain complex with SRP and SRP receptor in early state A; 5S ribosomal RNA 7nfx 8 156 3.2 RF00002 URS00004B2C76_9986 34020957 0003735 0005840 9986 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<.<<.....>>>.....(.<<<......>>.............>>>..)...>>>....<<<..>>><<<<<<<<.......>>>>>>>>.................... .........................................((((((.[[....[)))...].(.(((......]].............)))..)...)))....((....))((((((((.......)))))))).................... Mammalian ribosome nascent chain complex with SRP and SRP receptor in early state A; 5.8S ribosomal RNA 7nga Y 15 3.9 URS0000E60B84_10879 34795277 10879 uccaugcgcaugacg ............... ............... CryoEM structure of the MDA5-dsRNA filament in complex with ADP with 88-degree helical twist; RNA (5'-R(P*UP*CP*CP*AP*UP*GP*CP*GP*CP*AP*UP*GP*AP*CP*G)-3') 7nga X 15 3.9 URS0000E60BC3_10879 34795277 10879 cgucaugcgcaugga ............... ............... CryoEM structure of the MDA5-dsRNA filament in complex with ADP with 88-degree helical twist; RNA (5'-R(P*AP*CP*GP*UP*CP*AP*UP*GP*CP*GP*CP*AP*UP*GP*G)-3') 7nha D 15 2.91 URS000197CF81_32630 35017564 32630 aguagaaacaaggcc .<<....>>...... .((....))...... 1918 H1N1 Viral influenza polymerase heterotrimer - Endonuclease and priming loop ordered (Class2a); RNA (5'-R(P*AP*GP*UP*AP*GP*AP*AP*AP*CP*AP*AP*GP*GP*CP*C)-3') 7nhc D 15 2.87 URS000197CF81_32630 35017564 32630 aguagaaacaaggcc .<<....>>...... .((....))...... 1918 H1N1 Viral influenza polymerase heterotrimer - Endonuclease ordered (Class2b); RNA (5'-R(P*AP*GP*UP*AP*GP*AP*AP*AP*CP*AP*AP*GP*GP*CP*C)-3') 7nhk A 2905 2.9 RF02540,RF02541,RF00002 URS0002311A01_1351 34117249 0003735 0005840 1351 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LsaA, an antibiotic resistance ABCF, in complex with 70S ribosome from Enterococcus faecalis; 23S rRNA 7nhk B 114 2.9 RF00001 URS0000240630_1351 34117249 0003735 0005840 1351 gugguggcgauagcgagaaggauacaccuguucccaugccgaacacagaaguuaagcuucuuagcgccgauuguagugaaggguuucccuuugugagaguaggacgucgccacg <<<<<<<<....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<.....<.<<<<<<<<...>>>>>>>>...>...>>..>>>>>>>>. ((((((((....((((((((.....((((((...(.....)...))))..))....)))))).)).((.......((((((((...)))))))).......))..)))))))). LsaA, an antibiotic resistance ABCF, in complex with 70S ribosome from Enterococcus faecalis; 5S rRNA 7nhk a 1517 2.9 RF00177,RF01959,RF01960 URS0002311A16_1351 34117249 0003735 0005840 1351 gagaguuugauccuggcucaggacgaacgcuggcggcgugccuaauacaugcaagucgaacgcuucuuaagaggaguggcggacgggugaguaacacguggguaaccuacccaucagagggggauaacacuuggaaacaggugcuaauaccgcauaacaguuuaugccgcauggcauaagagugaaaggcgcuggugucgcugauggauggacccgcggugcauuagcuaguuggugagguaacggcucaccaaggccacgaugcauagccgaccugagagggugaucggccacacugggacugagacacggcccagacuccuacgggaggcagcaguagggaaucuucggcaauggacgaaagucugaccgagcaacgccgcgugagugaagaagguuuucggaucguaaaacucuguuguuagagaagaacaaggacguuaguaacugaacguccccugacgguaucuaaccagaaagccacggcuaacuacgugccagcagccgcgguaauacguagguggcaagcguuguccggauuuauugggcguaaagcgagcgcaggcgguuucuuaagucugaugugaaagcccccggcucaaccggggagggucauuggaaacugggagacuugagugcagaagaggagaguggaauuccauguguagcggugaaaugcguagauauauggaggaacaccaguggcgaaggcggcucucuggucuguaacugacgcugaggcucgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugagugcuaaguguuggaggguuuccgcccuucagugcugcagcaaacgcauuaagcacuccgccuggggaguacgaccgcaagguugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggucuugacauccuuugaccacucuagagauagagcuuucccgggacaaagugacagguggugcaugguugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuuauuguuaguugccaucauuuaguugggcacucuagcgagacugccggugacaaaccggaggaagguggggaugacgucaaaucaucaugccccuuaugaccugggcuacacacgugcuacaaugggaaguacaacgagucgcuagaccgcgaggucaugcaaaucucuuaaagcuucucucaguucggauugcaggcugcaacucgccugcaugaagccggaaucgcuaguaaucgcggaucagcacgccgcggugaauacguucccgggccuuguacacaccgcccgucacaccacgagaguuuguaacacccgaagucggugagguaaccuuuuuggagccagccgccuaaggugggauagaugauuggggugaagucguaacaagguagccguaucggaaggugcggcuggaucaccuccu ..<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<<<....>>>>.>>>>>......<<........<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<.<<<<<<<<<..>>>>>>>>>..>....<<<<<..>>>>>.>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<<<<<<<.........<<<<<<<........>>>>>>>..........>>>>>>...>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<.......<<<<<<.....>>>>>>.....>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<<..<<<......>>>.....>>>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<<....>>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<........<<<<<....>>>>>....<<<>>>.....>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<......>>>>>...>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<..<<<<...<<.<<<<..<<<..<<.....>>.>>>.>>>>.>>..>>>>..>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ ..((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..(..((((....))))..))))......(((.......(((((((..((...(((((((.(.((.....(((((......)))))......)).).......((((((((....)))))))).......(((((()))))).)))))))..))))))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....((((((...(.....(((((((........))))))).....)....))))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))...).)))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((((((....)))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((...(....(((((....)))))....((())).)...).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..((......)))))...)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((..((((....(.((((..(((..((.....)).))).)))).)...))))..))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... LsaA, an antibiotic resistance ABCF, in complex with 70S ribosome from Enterococcus faecalis; 16S rRNA 7nhk D 74 2.9 RF00005 URS00023119F2_1351 34117249 0030533 0006412 1351 cgcgggguggagcagucagguagcucgucgggcucauaacccgaaggucguagguucaaauccugcccccgcaa .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>.. .((((((..((((......[..)))).(((((.......))))).....(((((..]....))))))))))).. LsaA, an antibiotic resistance ABCF, in complex with 70S ribosome from Enterococcus faecalis; tRNA-fMETi 7nhk b 13 2.9 34117249 1351 ggagguaugacaa ............. ............. LsaA, an antibiotic resistance ABCF, in complex with 70S ribosome from Enterococcus faecalis; RNA (5'-R(P*GP*GP*AP*GP*GP*UP*AP*UP*GP*AP*CP*AP*A)-3') 7nhl D 73 3.1 RF00005 URS000231199A_93061 34117249 0030533 0006412 93061 gcgggguggagcagucagguagcucgucgggcucauaacccgaaggucguagguucaaauccugcccccgcaa <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>.. ((((((..((((......[..)))).(((((.......))))).....(((((..]....))))))))))).. VgaA-LC, an antibiotic resistance ABCF, in complex with 70S ribosome from Staphylococcus aureus; P-tRNA fMet 7nhl A 2914 3.1 RF02540,RF02541,RF00002 URS000024712F_93061 34117249 0003735 0005840 93061 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VgaA-LC, an antibiotic resistance ABCF, in complex with 70S ribosome from Staphylococcus aureus; 23S rRNA 7nhl a 1538 3.1 RF00177,RF01959,RF01960 URS00023119DF_93061 34117249 0003735 0005840 93061 ggagaguuugauccuggcucaggaugaacgcuggcggcgugccuaauacaugcaagucgagcgaacggacgagaagcuugcuucucugauguuagcggcggacgggugaguaacacguggauaaccuaccuauaagacugggauaacuucgggaaaccguagcuaauaccggauaauauuuugaaccgcaugguucaaaagugaaagacggucuugcugucacuuauagauggauccgcgcugcauuagcuaguugguaagguaacggcuuaccaaggcaacgaugcauagccgaccugagagggugaucggccacacuggaacugagacacgguccagacuccuacgggaggcagcaguagggaaucuuccgcaaugggcgaaagccugacggagcaacgccgcgugagugaugaaggucuucggaucguaaaacucuguuauuagggaagaacauauguguaaguaacugugcacaucuugacgguaccuaaucagaaagccacggcuaacuacgugccagcagccgcgguaauacguagguggcaagcguuauccggaauuauugggcguaaagcgcgcguaggcgguuuuuuaagucugaugugaaagcccacggcucaaccguggagggucauuggaaacuggaaaacuugagugcagaagaggaaaguggaauuccauguguagcggugaaaugcgcagagauauggaggaacaccaguggcgaaggcgacuuucuggucuguaacugacgcugaugugcgaaagcguggggaucaaacaggauuagauacccugguaguccacgccguaaacgaugagugcuaaguguuaggggguuucccgccccuuagugcugcagcuaacgcauuaagcacuccgccuggggaguacgaccgcaagguugaaacucaaaggaauugacggggacccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaaaucuugacauccuuugacaacucuagagauagagccuuccggacaaagugacagguggugcaugguugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuuaagcuuaguugccaucauuaaguugggcacucuaaguugacugccggugacaaaccggaggaagguggggaugacgucaaaucaucaugccccuuaugauuugggcuacacacgugcuacaauggacaauacaaagggcagcgaaaccgcgaggucaagcaaaucccauaaaguuguucucaguucggauuguagucugcaacucgacuacaugaagcuggaaucgcuaguaaucguagaucagcaugcuacggugaauacguucccgggucuuguacacaccgcccgucacaccacgagaguuuguaacacccgaagccgguggaguaaccuuuuaggagcuagccgucgaaggugggacaaaugauuggggugaagucguaacaagguagccguaucggaaggugcggcuggaucaccuccu ...<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<<<...<<<.........>.>>...>>>>.>>>>>......<<........<<<<<<<..<<...<<<<<<<.<<<<.....<<.<<<....>>>.>>......>>>>......<<<.<<<<<<..>>>>>>>>>.......<<<<<<...>>>>>>.>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<<<<<<<.......<.<<<<<<<........>>>>>>>.>........>>>>>>...>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<<..<<<.<<<<<<<.<<<<<<<<<.......<<<<<<.....>>>>>>.....>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>.>..........<<....>>.>>>>>>>..>>>>>.>>>...>>>..>>>>>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<<.....>>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<.....<<<<<....>>>>>..........>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<......>>>>>...>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<..<.<<<<<<<........>>>>>>>>...>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<..<<<<....<.<<<<..<<<..<<<...>>>.>>>.>>>>.>...>>>>..>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ ...((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((....((((.......).)))....))).)))))......(((.......(((((((..((...(((((((.((((.....((.(((....))).))......))))......(.(((((((....))))).)))......((((((...)))))).)))))))..))))))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..(((.......((((....))))......)))....((((((...(.....(((((((........))))))).....)....))))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))...).)))))))..)))))))))..(((.(((((...(((((((.....(((((.(...((........))......).)))))............((....)).)))))))..)))))..))..))))...))))....((((((....(...((((.........))))...).))))))..........((((((..((((((((((((...(..)))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((.....(((((....)))))..........)))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..((......)))))...)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((..((((....(.((((..(((..(((...))).))).)))).)...))))..))))))..))).))))..).))...)..)..(((((((((....)))))))))............ VgaA-LC, an antibiotic resistance ABCF, in complex with 70S ribosome from Staphylococcus aureus; 16S rRNA 7nhl B 113 3.1 RF00001 URS0000062A7E_93061 34117249 0003735 0005840 93061 cuggugacuauagcaaggaggucacaccuguucccaugccgaacacagaaguuaagcuccuuagcgucgaugguagucgaacuuacguuccgcuagaguagaacguugccagg <<<<<<<<....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<.....<<<<.<<<<....>>>>.>>>..>...>>..>>>>>>>>. ((((((((....((((((((.....((((((...(.....)...))))..))....)))))).)).((.......((.((((....)))).)).......))..)))))))). VgaA-LC, an antibiotic resistance ABCF, in complex with 70S ribosome from Staphylococcus aureus; 5S rRNA 7nhm A 2824 3.1 RF02540,RF02541,RF00002 URS000024712F_93061 34117249 0003735 0005840 93061 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((((((......((((((((((.....(((..(((((((((((((......((((((.[[..[[[)))...].((((((...(((]]..]].)))......))))))...)))....(((....)))(((((((......))))))).(((((((((.........))))))).)).))....(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...((((((((....))))))))....{.(((((((((.....((((.......((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))).)))))..)))))....(((((((...[.......)))))))....}.(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((..((((..[...))))..)))).<.(.(........).).((((((..(.(((((((.(((((..(((...(((.....)))...)))...((....))..((((.....)))).....))))).)))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)<)))...(((.(((((.......A))))))))..).))))))))).(.(((....[)))...).]))))))......).))).((((((....(((((....)))))(((((((((...(((((((((.....(((...((((((((...(.(..((.)).)..)....))))))))..)).).....)))).)))))..))))))).))..((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((.(((((.....{.(((((.(((..(((.........)))..))).....(...((......)).).)))))...))))).)))).))...........]]].)...))))))))))...)))))))(((((((...)))))))....))))))(.(((((((.((......(((((.((....))])))))...)).)))))))..).....))))))(......((....((((((.......))))))((((....(((...((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((((..((.......((...((((....((((..(((..(((((.((((((....{{...))))))((..(((((..(((((((((((.((.....))))))))).....))))..)))))...))...(((.((.....)).)))...)))))...)))...))))(..).....))))..))..))..))))))))))).))).....((......))..))).(((.......)))..))))..((((....((((((((.((..(....(.......(((((....(.[..).....)))))(((((((.((((....)))).)))))))(...).......(((((((((.>.((.........))...(((((((.....(((....))).......))))))).]((((.(((..(((((((..(((...((...(((((..((....))...)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).).[)))])))))))).)))))).....)).[..(((((.....>].)))))..((((((((.(((.((......((((.((((((..(((((.(((((((((.((((.(()).))))....((.((((((.....)))))))).....)))))))))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..a.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))((((....)))....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))...))))))). 70S ribosome from Staphylococcus aureus; 23S rRNA 7nhm a 1531 3.1 RF00177,RF01959,RF01960 URS00023119DF_93061 34117249 0003735 0005840 93061 ggagaguuugauccuggcucaggaugaacgcuggcggcgugccuaauacaugcaagucgagcgaacggacgagaagcuugcuucucugauguuagcggcggacgggugaguaacacguggauaaccuaccuauaagacugggauaacuucgggaaaccguagcuaauaccggauaauauuuugaaccgcaugguucaaaagugaaagacggucuugcugucacuuauagauggauccgcgcugcauuagcuaguugguaagguaacggcuuaccaaggcaacgaugcauagccgaccugagagggugaucggccacacuggaacugagacacgguccagacuccuacgggaggcagcaguagggaaucuuccgcaaugggcgaaagccugacggagcaacgccgcgugagugaugaaggucuucggaucguaaaacucuguuauuagggaagaacauauguguaaguaacugugcacaucuugacgguaccuaaucagaaagccacggcuaacuacgugccagcagccgcgguaauacguagguggcaagcguuauccggaauuauugggcguaaagcgcgcguaggcgguuuuuuaagucugaugugaaagcccacggcucaaccguggagggucauuggaaacuggaaaacuugagugcagaagaggaaaguggaauuccauguguagcggugaaaugcgcagagauauggaggaacaccaguggcgaaggcgacuuucuggucuguaacugacgcugaugugcgaaagcguggggaucaaacaggauuagauacccugguaguccacgccguaaacgaugagugcuaaguguuagggggccccuuagugcugcagcuaacgcauuaagcacuccgccuggggaguacgaccgcaagguugaaacucaaaggaauugacggggacccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaaaucuugacauccuuugacaacucuagagauagagccuuccggacaaagugacagguggugcaugguugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuuaagcuuaguugccaucauuaaguugggcacucuaaguugacugccggugacaaaccggaggaagguggggaugacgucaaaucaucaugccccuuaugauuugggcuacacacgugcuacaauggacaauacaaagggcagcgaaaccgcgaggucaagcaaaucccauaaaguuguucucaguucggauuguagucugcaacucgacuacaugaagcuggaaucgcuaguaaucguagaucagcaugcuacggugaauacguucccgggucuuguacacaccgcccgucacaccacgagaguuuguaacacccgaagccgguggaguaaccuuuuaggagcuagccgucgaaggugggacaaaugauuggggugaagucguaacaagguagccguaucggaaggugcggcuggaucaccuccu ...<<<<....((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<<........................>>>.>>>>>......<<........<<<<<<<..<<...<<<<<<<.<<<<.....<<.<<<....>>>.>>......>>>>......<<<<<<<<<....>>>>>>>>>......<<<<<<...>>>>>>.>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<<<<<<<.......<.<<<<<<..........>>>>>>.>........>>>>>>...>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<<..<<<.<<<<<<<.<<<<<<<<<.......<<<<<<.....>>>>>>.....>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>..>>>>>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<..>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..))))..<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<.....<<<<<....>>>>>..........>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<..<<<......>>>>>...>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<..<<<<....<.<<<<..<<<..<<<...>>>.>>>.>>>>.>...>>>>..>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ ...((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((........(.......).......))).)))))......(((.......(((((((..((...(((((((.((((.....((.(((....))).))......)))).....((((((((((....))))))))).)....((((((...)))))).)))))))..))))))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....((((((...(.....(((((((........))))))).....)....))))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))...).)))))))..)))))))))..(((.(((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))))..))..))))...))))....((((((....(...((((.........))))...).))))))..........((((((..(((((((((((())))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...((((((.....(((((....)))))..........)))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..((......)))))...)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....))))))))..)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((..((((....(.((((..(((..(((...))).))).)))).)...))))..))))))..))).))))..).))...)..)..(((((((((....)))))))))............ 70S ribosome from Staphylococcus aureus; 16S rRNA 7nhm B 113 3.1 RF00001 URS0000062A7E_93061 34117249 0003735 0005840 93061 cuggugacuauagcaaggaggucacaccuguucccaugccgaacacagaaguuaagcuccuuagcgucgaugguagucgaacuuacguuccgcuagaguagaacguugccagg <<<<<<<<....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<......<<<.<<<<....>>>>.>>>......>>..>>>>>>>>. ((((((((....((((((((.....((((((...(.....)...))))..))....)))))).)).((.......((.((((....)))).)).......))..)))))))). 70S ribosome from Staphylococcus aureus; 5S rRNA 7nhm D 77 3.1 RF00005 URS0002311A33_93061 34117249 0030533 0006412 93061 cgcgggauggagcagucagguagcucgucgggcucauaacccgaaggucggugguucaaauccgccucccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....((.((..]....)).))))))))..... 70S ribosome from Staphylococcus aureus; tRNA-fMet 7nhn D 74 2.9 RF00005 URS0002311A03_169963 34117249 0030533 0006412 169963 gcgggguggagcagucugguagcucgucgggcucauaacccgaaggucguagguucaaauccugcccccgcaac <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))... VgaL, an antibiotic resistance ABCF, in complex with 70S ribosome from Listeria monocytogenes; tRNA-fMet 7nhn A 2908 2.9 RF02540,RF02541,RF00002 URS0000D28EF9_169963 34117249 0003735 0005840 169963 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((((((......((((((((((.....(((..(((((((((((((......((((((.[[..[[[)))...].((((((...(((]]..]].)))......))))))...)))....(((....)))(((((((......))))))).(((((((((.........))))))))).))....((((((.....(...[..)......))))).).........((....))...((((......((.]...)).....))))...((((...(((((((((..)))))))))....{.(((((((((.....((((........(((((((((.(((...(.((((......)))))[[(...).(((.....]])))...)))...))))))))).)))).)))))..)))))....((((((((..[......))))))))....}.(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((..((((..[...))))..)))).<.(.(........).).((((((..(.(((((((((((((..(((...((.......))...)))...((....))..((((.....))))......)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)<)))...(((.(((((.......A))))))))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))((((((((....((((((((((.....(((...((((((((...(((((((.....))))).))...))))))))..)).).....))))).)))).).)))))).))..(((((((.((......)).)))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{..((((.(((..(((.........)))..))).....(...((......)).).))))....)))))))))).))...........]]].)...))))))))))...)))))))((((((()))))))....))))))(((((((((.((......(((((.((....))])))))...)).))))))).)).....))))))(......((....((((((.......))))))((((....(((...((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]]((((((((.((......((...(((((...((((..(((..(((((.(((((....{{....))))).((..(((((..((((.((((((.((.....))))))))......))))..)))))...))..........)))))...)))...))))(..)....)))))..))..)).)))))))))))).))).....((......))..))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))(((((....((((....))))...)))))(...).......(((((((((.>.((.........))...(((((((.....(((....)))..[....))))))).}((((.(((..(((((((..(((...((...(((((..((....))...)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).[..(((((.....>].)))))..((((((((.(((.((......((((.((((((..(((((.(((((((((.(((((.(.((((.((..(......[..(((((..(((.......(((((((....)))))))....)))..........].))))))..)).)))).).)))))....((.((((((...].)))))))).....)))))))))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))..a.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..((((....))))....(((.(((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))....)))....)))))).. VgaL, an antibiotic resistance ABCF, in complex with 70S ribosome from Listeria monocytogenes; 23S rRNA 7nhn a 1513 2.9 RF00177,RF01959,RF01960 URS0002311A12_169963 34117249 0003735 0005840 169963 gagaguuugauccuggcucaggacgaacgcuggcggcgugccuaauacaugcaagucgaacgaacggauguuaguggcggacgggugaguaacacgugggcaaccugccuguaaguuggggauaacuccgggaaaccggggcuaauaccgaaugauaaaguguggcgcaugccacgcuuuugaaagaugguuucggcuaucgcuuacagaugggcccgcggugcauuagcuaguugguaggguaauggccuaccaaggcaacgaugcauagccgaccugagagggugaucggccacacugggacugagacacggcccagacuccuacgggaggcagcaguagggaaucuuccgcaauggacgaaagucugacggagcaacgccgcguguaugaagaagguuuucggaucguaaaguacuguuguuagagaagaacaaggauaagaguaacugcuugucccuugacgguaucuaaccagaaagccacggcuaacuacgugccagcagccgcgguaauacguagguggcaagcguuguccggauuuauugggcguaaagcgcgcgcaggcggucuuuuaagucugaugugaaagcccccggcuuaaccggggagggucauuggaaacuggaagacuggagugcagaagaggagaguggaauuccacguguagcggugaaaugcguagauauguggaggaacaccaguggcgaaggcgacucucuggucuguaacugacgcugaggcgcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugagugcuaaguguuaggggguuuccgccccuuagugcugcagcuaacgcauuaagcacuccgccuggggaguacgaccgcaagguugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggucuugacauccuuugaccacucuggagacagagcuuucccgggacaaagugacagguggugcaugguugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuugauuuuaguugccagcauuuaguugggcacucuaaagugacugccggugcaagccggaggaagguggggaugacgucaaaucaucaugccccuuaugaccugggcuacacacgugcuacaauggauaguacaaagggucgcgaagccgcgagguggagcuaaucccauaaaacuauucucaguucggauuguaggcugcaacucgccuacaugaagccggaaucgcuaguaaucguggaucagcaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccacgagaguuuguaacacccgaagucgguaggguaaccggagccagccgccgaaggugggacagauaauuggggugaagucguaacaagguagccguaucggaaggugcggcuggaucaccuccu ..<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<<<..>>>>.>>>>>......<<........<<<<<<<..<<...<<<<<<<<<.<<.....<<<<<<....>>>>>>......>>.>.....<<<<<<<<<<....>>>>>>>>>>.....<<<<<<....>>>>>>>>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<<<<<<<.......<<<<<<<<<........>>>>>>>.>>.......>>>>>>...>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<.......<<<<<<.....>>>>>>.....>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<<..<<<......>>>.....>>>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<<....>>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<....<<<<<....>>>>>....<<<>>>.>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<......>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<..<<<<....<.<<<<..<<<..<<>>.>>>.>>>>.>...>>>>..>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ ..((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((....))).)))))......(((.......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....((((((((((....)))))))))).....(((((......))))).)))))))..))))))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......(((......))).....))))....((((((...(.....(((((((........))))))).....)....))))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))...).)))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((((((....)))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((.....(((((....)))))....((()))..)))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..((......)))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...((((((......(((..((...(((....)))...))....)))......))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((..((((....(.((((..(((..(()).))).)))).)...))))..))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... VgaL, an antibiotic resistance ABCF, in complex with 70S ribosome from Listeria monocytogenes; 16S rRNA 7nhn B 114 2.9 RF00001 URS0002311A24_169963 34117249 0003735 0005840 169963 cugguaguuauggcgagaaggucacacccguucccaucccgaacacgguaguuaagcuucucugcgccaaugguaguugggggcuucccccugcgagaguaggucgcugccggg <<<<<<<<....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>><<<.......<<.<<<<<...>>>>>.>>.......>>>.>>>>>>>>. ((((((((....((((((((.....((((((...(.....)...))))..))....)))))).))(((.......((.(((((...))))).)).......))).)))))))). VgaL, an antibiotic resistance ABCF, in complex with 70S ribosome from Listeria monocytogenes; 5S rRNA 7nhx F 15 3.23 URS000197CF81_88776 35017564 88776 aguagaaacaaggcc .<<....>>...... .((....))...... 1918 H1N1 Viral influenza polymerase heterotrimer - full transcriptase (Class1); RNA (5'-R(P*AP*GP*UP*AP*GP*AP*AP*AP*CP*AP*AP*GP*GP*CP*C)-3') 7ni0 D 15 3.32 URS000197CF81_88776 35017564 88776 aguagaaacaaggcc .<<....>>...... .((....))...... 1918 H1N1 Viral influenza polymerase heterotrimer - Replicase (class 3); RNA (5'-R(P*AP*GP*UP*AP*GP*AP*AP*AP*CP*AP*AP*GP*GP*CP*C)-3') 7nic X 15 4.3 URS0000E60BB0_32630 34795277 32630 gucaagccgaggaga ............... ............... CryoEM structure of disease related M854K MDA5-dsRNA filament in complex with ADP-AlF4(minor class); RNA (5'-R(P*GP*UP*CP*AP*AP*GP*CP*CP*GP*AP*GP*GP*AP*GP*A)-3') 7nic Y 15 4.3 URS0000E60BD6_32630 34795277 32630 ucuccucggcuugac ............... ............... CryoEM structure of disease related M854K MDA5-dsRNA filament in complex with ADP-AlF4(minor class); RNA (5'-R(P*UP*CP*UP*CP*CP*UP*CP*GP*GP*CP*UP*UP*GP*AP*C)-3') 7nik D 15 6.2 URS000197CF81_88776 35017564 88776 aguagaaacaaggcc .<<....>>...... .((....))...... 1918 H1N1 Viral influenza polymerase heterotrimer with Nb8189 core; RNA (5'-R(P*AP*GP*UP*AP*GP*AP*AP*AP*CP*AP*AP*GP*GP*CP*C)-3') 7nil D 15 5.01 URS000197CF81_88776 35017564 88776 aguagaaacaaggcc .<<....>>...... .((....))...... 1918 H1N1 Viral influenza polymerase heterotrimer with Nb8190 core; RNA (5'-R(P*AP*GP*UP*AP*GP*AP*AP*AP*CP*AP*AP*GP*GP*CP*C)-3') 7niq C 14 4.3 URS0002311A2C_10879 34795277 10879 caagccgaggagau .............. .............. CryoEM structure of disease related M854K MDA5-dsRNA filament in complex with ADP-AlF4(Major class); RNA (5'-R(P*CP*AP*AP*GP*CP*CP*GP*AP*GP*GP*AP*GP*AP*U)-3') 7niq G 14 4.3 URS0002311966_10879 34795277 10879 aucuccucggcuug .............. .............. CryoEM structure of disease related M854K MDA5-dsRNA filament in complex with ADP-AlF4(Major class); RNA (5'-R(P*AP*UP*CP*UP*CP*CP*UP*CP*GP*GP*CP*UP*UP*G)-3') 7nir D 15 6.7 URS000197CF81_88776 35017564 88776 aguagaaacaaggcc .<<....>>...... .((....))...... 1918 H1N1 Viral influenza polymerase heterotrimer with Nb8191 core; RNA (5'-R(P*AP*GP*UP*AP*GP*AP*AP*AP*CP*AP*AP*GP*GP*CP*C)-3') 7nis D 15 5.96 URS000197CF81_88776 35017564 88776 aguagaaacaaggcc .<<....>>...... .((....))...... 1918 H1N1 Viral influenza polymerase heterotrimer with Nb8192 core; RNA (5'-R(P*AP*GP*UP*AP*GP*AP*AP*AP*CP*AP*AP*GP*GP*CP*C)-3') 7nj3 D 15 4.48 URS000197CF81_88776 35017564 88776 aguagaaacaaggcc .<<....>>...... .((....))...... 1918 H1N1 Viral influenza polymerase heterotrimer with Nb8196 core; RNA (5'-R(P*AP*GP*UP*AP*GP*AP*AP*AP*CP*AP*AP*GP*GP*CP*C)-3') 7nj4 D 15 5.84 URS000197CF81_88776 35017564 88776 aguagaaacaaggcc .<<....>>...... .((....))...... 1918 H1N1 Viral influenza polymerase heterotrimer with Nb8198 core; RNA (5'-R(P*AP*GP*UP*AP*GP*AP*AP*AP*CP*AP*AP*GP*GP*CP*C)-3') 7nj5 D 15 4.63 URS000197CF81_88776 35017564 88776 aguagaaacaaggcc .<<....>>...... .((....))...... 1918 H1N1 Viral influenza polymerase heterotrimer with Nb8199 core; RNA (5'-R(P*AP*GP*UP*AP*GP*AP*AP*AP*CP*AP*AP*GP*GP*CP*C)-3') 7nj7 D 15 4.82 URS000197CF81_88776 35017564 88776 aguagaaacaaggcc .<<....>>...... .((....))...... 1918 H1N1 Viral influenza polymerase heterotrimer with Nb8200 core; RNA (5'-R(P*AP*GP*UP*AP*GP*AP*AP*AP*CP*AP*AP*GP*GP*CP*C-3') 7nk1 D 15 4.22 URS000197CF81_88776 35017564 88776 aguagaaacaaggcc .<<....>>...... .((....))...... 1918 Influenza virus polymerase heterotirmer in complex with vRNA promoters and Nb8201; RNA (5'-R(P*AP*GP*UP*AP*GP*AP*AP*AP*CP*AP*AP*GP*GP*CP*C)-3') 7nk2 D 15 4.84 URS000197CF81_88776 35017564 88776 aguagaaacaaggcc .<<....>>...... .((....))...... 1918 H1N1 Viral influenza polymerase heterotrimer with Nb8202 core; RNA (5'-R(P*AP*GP*UP*AP*GP*AP*AP*AP*CP*AP*AP*GP*GP*CP*C)-3') 7nk4 D 15 5.32 URS000197CF81_88776 35017564 88776 aguagaaacaaggcc .<<....>>...... .((....))...... 1918 H1N1 Viral influenza polymerase heterotrimer with Nb8203 core; RNA (5'-R(P*AP*GP*UP*AP*GP*AP*AP*AP*CP*AP*AP*GP*GP*CP*C)-3') 7nk6 D 15 6.72 URS000197CF81_32630 35017564 32630 aguagaaacaaggcc .<<....>>...... .((....))...... 1918 H1N1 Viral influenza polymerase heterotrimer with Nb8204; RNA (5'-R(P*AP*GP*UP*AP*GP*AP*AP*AP*CP*AP*AP*GP*GP*CP*C)-3') 7nk8 D 15 5.34 URS000197CF81_32630 35017564 32630 aguagaaacaaggcc .<<....>>...... .((....))...... 1918 H1N1 Viral influenza polymerase heterotrimer with Nb8205 core; RNA (5'-R(P*AP*GP*UP*AP*GP*AP*AP*AP*CP*AP*AP*GP*GP*CP*C)-3') 7nka D 15 4.07 URS000197CF81_32630 35017564 32630 aguagaaacaaggcc .<<....>>...... .((....))...... 1918 H1N1 Viral influenza polymerase heterotrimer with Nb8206; RNA (5'-R(P*AP*GP*UP*AP*GP*AP*AP*AP*CP*AP*AP*GP*GP*CP*C)-3') 7nkc D 15 4.46 URS000197CF81_32630 35017564 32630 aguagaaacaaggcc .<<....>>...... .((....))...... 1918 H1N1 Viral influenza polymerase heterotrimer with Nb8207; RNA (5'-R(P*AP*GP*UP*AP*GP*AP*AP*AP*CP*AP*AP*GP*GP*CP*C)-3') 7nki D 15 4.67 URS000197CF81_88776 35017564 88776 aguagaaacaaggcc .<<....>>...... .((....))...... 1918 H1N1 Viral influenza polymerase heterotrimer with Nb8209 core; RNA (5'-R(P*AP*GP*UP*AP*GP*AP*AP*AP*CP*AP*AP*GP*GP*CP*C)-3') 7nkr D 15 5.6 URS000197CF81_32630 35017564 32630 aguagaaacaaggcc .<<....>>...... .((....))...... 1918 H1N1 Viral influenza polymerase heterotrimer with Nb8210; RNA (5'-R(P*AP*GP*UP*AP*GP*AP*AP*AP*CP*AP*AP*GP*GP*CP*C)-3') 7nqh AA 960 3.5 RF00177,RF01959 URS00000CFF65_9823 33878294 0003735 0005840 9823 acagguuugguccuggccuuucuauuaauucuuaauaaaauuacacaugcaaguauccgcgccccggugagaaugcccuccagaucuuaaagaucaaaaggagcagguaucaagcacaccuauaacgguagcucauaacgccuugcucaaccacacccccacgggaaacagcagugauaaaaauuaagccaugaacgaaaguuugacuaaguuauauuaauuagaguugguaaaucucgugccagccaccgcggucauacgauuaacccaaauuaauagauccacggcguaaagaguguuuaagaaaaaaaaucacaauagaguuaaauuauaacuaagcuguaaaaagcccuaguuaaaauaaaauaacccacgaaagugacucuaauaauccugacacacgauagcuaggacccaaacugggauuagauaccccacuaugccuagcccuaaacccaaauaguuacauaacaaaacuauucgccagaguacuacucgcaacugccuaaaacucaaaggacuuggcggugcuucacauccaccuagaggagccuguucuauaaucgauaaaccccgauagaccuuaccaacccuugccaauucagccuauauaccgccaucuucagcaaacccuaaaaaggaacaauaguaagcacaaucauagcacauaaaaacguuaggucaagguguagcuuauggguuggaaagaaaugggcuacauuuucuacauaagaauauccaccacacgaaaguuuuuaugaaacuaaaaaccaaaggaggauuuagcaguaaaucaagaauagagugcuugauugaauaaggccaugaagcacgcacacaccgcccgucacccuccucaagcauguaguaauaaaaauaaccuauauucaauuacacaaccaugcaagaagagacaagucguaacaagguaagcauacuggaaagugugcuuggauuacc ..((((..<<<<<<.)))).<<<<<<<<<..<<<<<<<<..<.<<<.<<<..<<....>>......<<......<<<<<...<<<<<...>>>>>...>>>.>>.<<<....<<...<<<......>>>..>>......>>>..<.....>.>>.<<<....>>>.....>>>>>>>.........<<....<<<<....>>>>..>>...>>.>>>>>>...<.<<<<<<.....(((.....((.>>>)).......)))..>>>.>..>>>>>>>>>.....<<<((.....<<<<...<<..............<<<<<<.......<<<<<<.<<<......>>>..>>>>>>.............<<<....>>>>>>>>>......>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<<.....))..>>>>>>>.>>>.<<<........<<....>>......>>>..>>>>>><<<<<.<<<<<<<...<<..<<<<<..<<<<<<<<<<.....<<........>>..........<<<<<<<..........<<<.<<<..<<<<<<.......<<..<<<<<....>>>.......>>..>>......<<.....>>..........>>>...>>>>>>>>>...>>>>>>>..>>.>>>>>>>>.....<<<<.....>>>>...........<....<<<<<<<......>>>>>>>....>.....>>>>>.....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<...<<<.<<..<<<<<..<<<<<...<<<<.....>>>>..>>>>>.....>>>>>..>>.>>>....>.>>...>.....<<<<<<<<<....>>>>>>>>>........ [.[[[[..(((((..]]]]](((((((((..((((((((..(.(((.(((..((....))......(((.....(((((...(((((...)))))...))).)).(((....((..((((......))).)))......)))..(.....)))).(((....))).....)))))))......(..((...(((((....)))).))).).)).))))))...(.((([[[.....(((.....((.]]])).......)))..))).)..))))))))).....((([[...(.((((...((..............(((((((......((((((.((........))..))))))......).....(.((....)))))))))......))...))))....((((((...((...((((.........))))...))))))))......{...(((((((.....]]..))))))))))).(((........((....))......)))...)))))(((((.(((((((...((..(((((..((((((((((.....((........))..........(((((((..(......).((.(((...((((((.(....((..(((((....))).......))..))......((.....))......).).)))...)).)))))....)))))))..)).)))))))).(...((((.....))))..(.....)..(....(((((((......)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(...(((.((..(((((..(((((...((((.....))))..))))).....)))))..)).)))....).))...)..)..(((((((((....)))))))))}....... 55S mammalian mitochondrial ribosome with mtRF1a and P-site tRNAMet; 12S rRNA 7nqh AV 71 3.5 URS0000D77905_9606 33878294 9606 aguaaggucagcuaaauaagcuaucgggcccauaccccgaaaauguugguuauacccuucccguacuacca <<<<.<<..<<<<.....>>>>.<<<<<.......>>>>>....<..<<......>>..>>>.>>>>.... ((((.((..((((.....)))).(((((.......)))))....(..((......))..))).)))).... 55S mammalian mitochondrial ribosome with mtRF1a and P-site tRNAMet; tRNAMet 7nqh BA 1544 3.5 RF02541,RF02540 URS000022E3AE_9823 33878294 0003735 0005840 9823 accaaagcuagcucaacauacuaaacaaauacaaaaauacaccaaaauaaaauaaaacauucaccuaacauuaaaguauaggagauagaaauuuuuauccugacgcuauagagauaguaccguaagggaaagaugaaagaauaaaauaaaaguaaaaaaaagcaaagauuaccccuucuaccuuuugcauaaugguuuaaccagaaaaaaucuaacaaagagaacuuuagcuagauaccccgaaaccagacgagcuacccaugagcaguuuaaaagaaccaacucaucuauguggcaaaauagugagaagacuuguagguagaggugaaaagccuaacgagccuggugauagcugguuguccgagaaagaauuuuaguucaaccuuaaaaauaccccaaaaacccuaaauuccaauguauuuuuaagagauagucuaaaaagguacagcuuuuuagaaacggauacaaccuugacuagagaguaaaaucuuaauacuaccauaguaggccuaaaagcagccaucaauugagaaagcguuaaagcucaacaaauucaccaacauaaucccaaaaacuaauaacaaacuccuagcccaauaccggacuaaucuauugaaacauagaagcaauaauguuaauaugaguaacaagaagccuuucuccucgcacacgcuuacaucaguaacuaauaauauacugauaauuaacaaccaauaaaccaaaacaacacuaaaacguuuauuaauuacauuguuaacccaacacaggagugcaccaaggaaagauuaaaagaaguaaaaggaacucggcaaacacaaaccccgccuguuuaccaaaaacaucaccucuagcauuacuaguauuagaggcaaugccugcccagugacaccaguuuaacggccgcgguauucugaccgugcaaagguagcauaaucacuuguucuccaaauaaggacuuguaugaauggccacacgaggguuuuacugucucuuacuuccaaucagugaaauuaaccuucccgugaagaggcgggaauaaaaaaauaagacgagaagacccuauggagcuuuaauuaacuauuccaaaaguuaauaacuuaacauggacuagcaauuucgguuggggugaccucggaguacaaaaaacccuccgagugauuuuaaucuagacaaaccagucaaaauaaccauaacaucacuuauugauccaaaauuuugaucaacggaacaaguuacccuagggauaacagcgcaauccuguucuagaguuccuaucgacaauaggguuuacgaccucgauguuggaucaggacacccaaauggugcaaccgcuauuaaagguucguuuguucaacgauuaaaguccuacgugaucugaguucagaccggagcaauccaggucgguuucuaucuauuauaaauuucucccaguacgaaaggacaagagaaaugggaccaaccucacaaacgcgucucagagauaauuaaugauuuaaucuuaaccuaauuaacucauaauaaauccagcccuagaacagggcaca <<.<.....<<<<<.......................................<......>.................<<.....>>..............>>.>>>............<<....>>...................>....>>...........<<<.......>>>...<.<........>.>..<<<<<........<<<<<.<..<<....>>...>.>>>>>..<<.<..<<<<<.<.....<<<.<<<<<..<<<......>>>...<<<..<<<<........>>>>.>>>....>>>>>.>>>...<<<.....>>>......>.>>>>...>..>.>>..<<<<<.....<<<<....>>>>..<<<<<<<<<<<<.....<<........>>.....>>>>>>>>>>>.>....<<<<<<<<<......>>>>>>>>>...<<......>>....<<<<.<<<...................<....<<<.........>>>....>.......<<<......>>>........................................>>>>>>>........>>>>>...<<<<<......>>>>>.........>>>>>.<......<<..<<<<..>>>><<<<.<<<<........<<<<<....<<....>>..>>>>>......<<<..<<<<<<<.................>>>>>>>.......>>>.....<<......>>.>>>>....>>>>..<<<<....<<<<<<<.<<...............<<<<<<<<..<<<.........>>>...<<<<<<.............>>>>>>...<<<<.<<<..<<<<<....>>>..>>>>><<<<<<......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>.>..>>.>>>>>>......>>.>>>>>>>.>>>>.>>.....>.....<<<<<........>>>>>.......<<<.<<<.<<......<<<<.<<<<<<..<<<<..<<<.<<<<.<<<<<<.>>>>>>....>>>>.>>>.>>>>..<<<<.....>>>><<<<<<...........>>>>>>.<<<<....<<...<<<......>>>...>>.........>>>>..........<<<....>>>............>>>>..>>>>>>.......<<<..<.<<<<<<...<<.......>>...>>>>>>...>.>>.>.......<<<<<.<<<<<<..<<.<<<<<<......>>>>>>...>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>>>>.<<.<<<<<<<.................>>>>>>><<<<<...<.........>.>>>>>.<<<...<<<<.<............>..>>>>...>>>.>>.........<<<<.......>>>>... ((.(...(..((((.......................................(...[..)........(..(.....((.]...))....)..)......)).)).............((....))....)..............)....))...........(((.......))).[.(.(........).)..(((((........(((((.(..((....))...).)))))..((.(...((((.(.....(((.((((((.((......[.))...(((..((((.......{)))).)))..).))))).))).(.(((.....)))...)..).))))......).))..(((((.....((((....))))...(((((((((((.....((........)).....)))))))))))......(((((((((......)))))))))...((......))....((((.(((...................(.(..(((.........)))..).)....(..(((......)))).......................................)))))))........)))))...(((((......))))).........))))).(......((..((((..))))(((..((((......(.(((((....((....))..)))))......(((..(((((((...........(..)..))))))).......))).)...((......)).)))).....)))..((((....(((((((.((..(....(.......((((((((.].((.........))....((((((.............))))))...((((.(((..(((((....)))..)))))(((((........)))))........((..........(((((.......)))))..)..)....))).)..)).))))))..)..))).))))))).)))).)).....)..{..(((((.....]}.))))).......(((.(((.((......((((.((((((..((((..(((.((((.((((((.))))))....)))).))).))))..(((......[)))((((((..........]))))))((((((..)((.(.(((...[..))))..)).........))))..........(((....))).....)].....))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......((((.((((((..((.((((((......))))))...)).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..}.))..)))))).((.(((((((......(....).....)))))))(((((...(.(.....).).))))).(((....(((.................)))....))).)).........((((.......))))... 55S mammalian mitochondrial ribosome with mtRF1a and P-site tRNAMet; 16S rRNA 7nql BA 1544 3.4 RF02541,RF02540 URS000022E3AE_9823 33878294 0003735 0005840 9823 accaaagcuagcucaacauacuaaacaaauacaaaaauacaccaaaauaaaauaaaacauucaccuaacauuaaaguauaggagauagaaauuuuuauccugacgcuauagagauaguaccguaagggaaagaugaaagaauaaaauaaaaguaaaaaaaagcaaagauuaccccuucuaccuuuugcauaaugguuuaaccagaaaaaaucuaacaaagagaacuuuagcuagauaccccgaaaccagacgagcuacccaugagcaguuuaaaagaaccaacucaucuauguggcaaaauagugagaagacuuguagguagaggugaaaagccuaacgagccuggugauagcugguuguccgagaaagaauuuuaguucaaccuuaaaaauaccccaaaaacccuaaauuccaauguauuuuuaagagauagucuaaaaagguacagcuuuuuagaaacggauacaaccuugacuagagaguaaaaucuuaauacuaccauaguaggccuaaaagcagccaucaauugagaaagcguuaaagcucaacaaauucaccaacauaaucccaaaaacuaauaacaaacuccuagcccaauaccggacuaaucuauugaaacauagaagcaauaauguuaauaugaguaacaagaagccuuucuccucgcacacgcuuacaucaguaacuaauaauauacugauaauuaacaaccaauaaaccaaaacaacacuaaaacguuuauuaauuacauuguuaacccaacacaggagugcaccaaggaaagauuaaaagaaguaaaaggaacucggcaaacacaaaccccgccuguuuaccaaaaacaucaccucuagcauuacuaguauuagaggcaaugccugcccagugacaccaguuuaacggccgcgguauucugaccgugcaaagguagcauaaucacuuguucuccaaauaaggacuuguaugaauggccacacgaggguuuuacugucucuuacuuccaaucagugaaauuaaccuucccgugaagaggcgggaauaaaaaaauaagacgagaagacccuauggagcuuuaauuaacuauuccaaaaguuaauaacuuaacauggacuagcaauuucgguuggggugaccucggaguacaaaaaacccuccgagugauuuuaaucuagacaaaccagucaaaauaaccauaacaucacuuauugauccaaaauuuugaucaacggaacaaguuacccuagggauaacagcgcaauccuguucuagaguuccuaucgacaauaggguuuacgaccucgauguuggaucaggacacccaaauggugcaaccgcuauuaaagguucguuuguucaacgauuaaaguccuacgugaucugaguucagaccggagcaauccaggucgguuucuaucuauuauaaauuucucccaguacgaaaggacaagagaaaugggaccaaccucacaaacgcgucucagagauaauuaaugauuuaaucuuaaccuaauuaacucauaauaaauccagcccuagaacagggcaca <<.<.....<<<<<.......................................<......>...........<.....<<.....>>....>.........>>.>>>............<<....>>...................>....>>...........<<<.......>>>...<.<........>.>..<<<<<........<<<<<.<..<<....>>...>.>>>>>..<<.<..<<<<<.<.....<<<.<<<<<..<<<......>>>...<<<..<<<<........>>>>.>>>....>>>>>.>>>...<<<.....>>>......>.>>>>...>..>.>>..<<<<<.....<<<<....>>>>..<<<<<<<<<<<<.....<<........>>.....>>>>>>>>>>>.>....<<<<<<<<<......>>>>>>>>>...<<......>>....<<<<.<<<...................<....<<<.........>>>....>.......<<<......>>>........................................>>>>>>>........>>>>>...<<<<<......>>>>>.........>>>>>.<......<<..<<<....>>><<<<.<<<<........<<<<<....<<....>>..>>>>>......<<<..<<<<<<<.................>>>>>>>.......>>>.....<<......>>.>>>>....>>>>..<<<<....<<<<<<<.<<...............<<<<<<<<..<<<.........>>>...<<<<<<.............>>>>>>...<<<<.<<<..<<<<<....>>>..>>>>><<<<<<......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>.>..>>.>>>>>>......>>.>>>>>>>.>>>>.>>.....>.....<<<<<........>>>>>.......<<<.<<<.<<......<<<<.<<<<<<..<<<<..<<<.<<<<.<<<<<<.>>>>>>....>>>>.>>>.>>>>..<<<<.....>>>><<<<<<...........>>>>>>.<<<<....<<...<<<......>>>...>>.........>>>>..........<<<....>>>............>>>>..>>>>>>.......<<<..<.<<<<<<...<<.......>>...>>>>>>...>.>>.>.......<<<<<.<<<<<<..<<.<<<<<<......>>>>>>...>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>>>>.<<.<<<<<<<.................>>>>>>><<<<<...<.........>.>>>>>.<<<...<<<<.<............>..>>>>...>>>.>>.........<<<<.......>>>>... ((.(...(..((((.......................................(...[..)........(..(.....((.]...))....)..)......)).)).............((....))....)..............)....))...........(((.......))).[.(.(........).)..(((((........(((((.(..((....))...).)))))..((.(...((((.(.....(((.((((((.(((.....[)))...(((..((((.......{)))).)))..).))))).))).(.((.......))...)..).))))......).))..(((((.....((((....))))...(((((((((((.....((........)).....)))))))))))......(((((((((......)))))))))...((......))....((((.(((...................(.(..(((.........)))..).)....(..(((......)))).......................................)))))))........)))))...(((((......))))).........))))).(......((..((((..))))(((..((((......(.(((((....((....))..)))))......(((..(((((((...........(..)..))))))).......))).)...((......)).)))).....)))..((((....(((((((.((..(....(.......((((((((.].((.........))....((((((.............))))))...((((.(((..(((((....)))..)))))(((((........)))))........((..........(((((.......)))))..)..)....))).)..)).))))))..)..))).))))))).)))).)).....)..{..(((((.....]}.))))).......(((.(((.((......((((.((((((..((((..(((.((((.((((((.))))))....)))).))).))))..(((......[)))((((((..........]))))))((((((..)((.(.(((...[..))))..)).........))))..........(((....))).....)].....))))..))))))......((((..(.(((.((...((.......))...)).)))...).)).).)......((((.((((((..((.((((((......))))))...)).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..}.))..)))))).((.(((((((......(....).....)))))))(((((...(.(.....).).))))).(((....(((.................)))....))).)).........((((.......))))... 55S mammalian mitochondrial ribosome with ICT1 and P site tRNAMet; 16S rRNA 7nql AA 960 3.4 RF00177,RF01959 URS00000CFF65_9823 33878294 0003735 0005840 9823 acagguuugguccuggccuuucuauuaauucuuaauaaaauuacacaugcaaguauccgcgccccggugagaaugcccuccagaucuuaaagaucaaaaggagcagguaucaagcacaccuauaacgguagcucauaacgccuugcucaaccacacccccacgggaaacagcagugauaaaaauuaagccaugaacgaaaguuugacuaaguuauauuaauuagaguugguaaaucucgugccagccaccgcggucauacgauuaacccaaauuaauagauccacggcguaaagaguguuuaagaaaaaaaaucacaauagaguuaaauuauaacuaagcuguaaaaagcccuaguuaaaauaaaauaacccacgaaagugacucuaauaauccugacacacgauagcuaggacccaaacugggauuagauaccccacuaugccuagcccuaaacccaaauaguuacauaacaaaacuauucgccagaguacuacucgcaacugccuaaaacucaaaggacuuggcggugcuucacauccaccuagaggagccuguucuauaaucgauaaaccccgauagaccuuaccaacccuugccaauucagccuauauaccgccaucuucagcaaacccuaaaaaggaacaauaguaagcacaaucauagcacauaaaaacguuaggucaagguguagcuuauggguuggaaagaaaugggcuacauuuucuacauaagaauauccaccacacgaaaguuuuuaugaaacuaaaaaccaaaggaggauuuagcaguaaaucaagaauagagugcuugauugaauaaggccaugaagcacgcacacaccgcccgucacccuccucaagcauguaguaauaaaaauaaccuauauucaauuacacaaccaugcaagaagagacaagucguaacaagguaagcauacuggaaagugugcuuggauuacc ..((((..<<<<<<.)))).<<<<<<<<<..<<<<<<<<..<.<<<.<<<..<<....>>......<<......<<<<<...<<<<<...>>>>>...>>>.>>.<<<....<<...<<<......>>>..>>......>>>..<.....>.>>.<<<....>>>.....>>>>>>>.........<<....<<<<....>>>>..>>...>>.>>>>>>...<.<<<<<<.....(((.....((.>>>)).......)))..>>>.>..>>>>>>>>>.....<<<((.....<<<<...<<..............<<<<<<.....<.<<<<<<.<<<......>>>..>>>>>>..>..........<<<....>>>>>>>>>......>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<......))...>>>>>>.>>>.<<<........<<....>>......>>>..>>>>>><<<<<.<<<<<<<...<<..<<<<<.<<<<<<<<<<<.....<<........>>..........<<<<<<<..........<<<.<<<..<<<<<<.......<<..<<<<<....>>>.......>>..>>......<<.....>>..........>>>...>>>>>>>>>...>>>>>>>..>>.>>>>>>>>.>...<<<<.....>>>>...........<....<<<<<<<......>>>>>>>....>.....>>>>>.....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<...<<<.<<..<<<<<..<<<<<...<<<<.....>>>>..>>>>>.....>>>>>..>>.>>>....>.>>...>.....<<<<<<<<<....>>>>>>>>>........ [.[[[[...((((..]]]]].((((((((..((((((((..(.(((.(((..((....))......(((.....(((((...((((.....))))...))).)).(((....((..((((......))).)))......)))..(.....)))).(((....))).....)))))))......(..((...(((((....)))).))).).)).))))))...(.((([[[.....(((.....((.]]])).......)))..))).)..))))))))......((([[...(.((((...((..............(((((((......((((((.((........))..))))))......).....(.((....)))))))))......))...))))....((((((...((...((((.........))))...))))))))......{...(((((((.....]]..))))))))))).(((........((....))......)))...)))).(((((.(((((((...((..(((((..((((((((((.....((........))..........(((((((..(......).((.(((...((((((.(....((..(((((....))).......))..))......((.....))......).).)))...)).)))))....)))))))..)).)))))))).(...((((.....))))...........(....(((((((......)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(...(((.((..(((((..(((((...(((.......)))..))))).....)))))..)).)))....).))...)..)..(((((((((....)))))))))}....... 55S mammalian mitochondrial ribosome with ICT1 and P site tRNAMet; 12S rRNA 7nql AV 71 3.4 URS0000D77905_9606 33878294 9606 aguaaggucagcuaaauaagcuaucgggcccauaccccgaaaauguugguuauacccuucccguacuacca <<<<.<<..<<<<.....>>>>.<<<<<.......>>>>>....<..<<......>>..>>>.>>>>.... ((((.((..((((.....)))).(((((.......)))))....(..((......))..))).)))).... 55S mammalian mitochondrial ribosome with ICT1 and P site tRNAMet; fMet-tRNAMet (P site) 7nrc S2 1771 3.9 RF01960,RF01959,RF00177 URS00005F2C2D_559292 33790014 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugagcuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauu ...<<<<<...((((>>>>><<<<.<<<<<<...<.<...<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<..<<..<<....<<<..................<<....<<.<<<.....>>>.>>.....>>.........<<<<<..<<....>>..>>>>><.<.<<<<<<......[[.((((.<<<....>>>....<<......>>>>>>>>.>...>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>..>>>..>....>.>.....<<<<<<<.<<<<<....>>>>>.>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>>.........<<<{{.....<.<<...<<<.<<....<<<<<<.<<<................>>>.>>>>>>.....<<<<<....................>>>>>....<<<<<.<<.......<<...<.......>..<<<<...>>>>....>>......>>.>>..>>>.........<<...<<<<<<<<.....)))).]].>>>>>>>>..>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..))))..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<......<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<<<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>...>.>>>>>>>.......>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>......<....<<<<<<..........>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<.<<<<.<<<<....>>>>.>>>>.>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>........ ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[..[[[.(.(....).).....(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(((((((.(.(((....))).).)))).)))....(.((..(...........)..))......)..((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((................))).)))))).....(((.(.....................))))....((((..((.......((..((.......)).(((.....)))....))......))..)..)))........((....(.((.(((.....]].].]].))).)).)...)..)..))...(((.(((.((...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)).)))..))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((..(..)..)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].].((((.(((((((..((..(((((..(((.((((((.......(........)...........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((.(..(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..))))).)..))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....((((((((.......))))))))......))...)))))))))).)...(.(..((.(..((((.((..(.(((((((..(((..(.((..(...((((((..(.((..(((....)).).)).)..))))))...)..)).)..)))..))))))))..)).))))...).))...)..)..(((((((((....)))))))))>....... Structure of the yeast Gcn1 bound to a leading stalled 80S ribosome with Rbg2, Gir2, A- and P-tRNA and eIF5A; 18S rRNA (1771-MER) 7nrc Sm 76 3.9 RF00005 URS000042DDAB_559292 33790014 0030533 0006412 559292 gggucguuagcucaguugguagagcaguugacuuuuaaucaauuggucgcagguucgaauccugcacgacccacca <<<<<<<..<<<<........>>>><<<<<<.......>>>>>>....<<<<<.......>>>>>>>>>>>>.... (((((((..((((........))))(.((((.......)))).)....(((((.......)))))))))))).... Structure of the yeast Gcn1 bound to a leading stalled 80S ribosome with Rbg2, Gir2, A- and P-tRNA and eIF5A; tRNA (76-MER) 7nrc Sn 75 3.9 RF00005 URS00021ED942_559292 33790014 0030533 0006412 559292 agcgccgugacgcaguggaagcgcgcagggcucauaacccugauguccucggaucgaaaccgagcggcgcuacca <<<<<<<...<<<.......>>>..<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((...(((....[..)))..(((((.......))))).....(((((..]....)))))))))))).... Structure of the yeast Gcn1 bound to a leading stalled 80S ribosome with Rbg2, Gir2, A- and P-tRNA and eIF5A; tRNA (75-MER) 7nrc LA 3184 3.9 RF02540,RF02543 URS0000A7632E_559292 33790014 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaugguguuuuguauuucacuggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauagagggcuaccuuuauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu .........................<<<<<.....<......>......>>>>>...........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[...........<<.<<<<<<...>>>>>>.>>.............<<<<<<<.<<<<<<<<<<<<<<<<<<<<.....<<<<......>>>>.(.......<<<......)>>>....>>>>>>>>>..>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<.........................<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<<..>>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<....<<.<<<<<<<.....<<<....<<<..<.<<<<...<<<<<<.....>>>>>>.>>>>.>..>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>..>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>>..<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<...............>>>>><<.<<<<<<<<<<<....>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.....<<....<<<<<....>>>>.>...>>..>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<<<<<<<<......>>>>>>.>>>>>>>>>>...<<<<<.....<<<<..<<<<........>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>..>>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<.<..<<<<<......>>>>>..>>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((...(((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))).)...)))..))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((......(..............)..(((((((((((((((((((((((.......(((((((......((((.((..)).)))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).<((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((....((.(((((((.....(((....(((..(.((((...((((((.....)))))).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((.(((...((.........))...))).....(...(........).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))((((((((((.((......((((.((((....))))))))...)))))))))).)).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....))).........(((.((.....).).)).)....))....))...(((((........)))))]]((((..(((.(((...((((....)))...(.[[((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....)))...))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.((((((((((.(...)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.((((((((..((.((((((((((.(((..)..)).))).))))))).))....((((.....((((..((((........))))..........]]...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....))))))))......(((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((.(.(..(((......)))..).).))).)))))).............)).))).)))))).)(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(((.((..)..).)))..)))))...)))....)))).)))))).))))).. Structure of the yeast Gcn1 bound to a leading stalled 80S ribosome with Rbg2, Gir2, A- and P-tRNA and eIF5A; 25S rRNA (3184-MER) 7nrc LB 121 3.9 RF00001 URS000055688D_559292 33790014 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<....<<<.<<..............>>....>>...>>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..).)...)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Structure of the yeast Gcn1 bound to a leading stalled 80S ribosome with Rbg2, Gir2, A- and P-tRNA and eIF5A; 5S rRNA (121-MER) 7nrc LC 158 3.9 RF00002 URS00001BF64E_559292 33790014 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Structure of the yeast Gcn1 bound to a leading stalled 80S ribosome with Rbg2, Gir2, A- and P-tRNA and eIF5A; 5.8S rRNA (158-MER) 7nrd S2 1783 4.36 RF01960,RF01959,RF00177 URS00005F2C2D_559292 33790014 0003735 0005840 559292 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Structure of the yeast Gcn1 bound to a colliding stalled 80S ribosome with MBF1, A/P-tRNA and P/E-tRNA; TPA_inf: Saccharomyces cerevisiae S288C chromosome XII, complete sequence 7nrd S3 32 4.36 33790014 559292 acuauaaaauuuucuuuucucucuuuuuuuuu ................................ ................................ Structure of the yeast Gcn1 bound to a colliding stalled 80S ribosome with MBF1, A/P-tRNA and P/E-tRNA; mRNA (32-MER) 7nrd Sn 75 4.36 RF00005 URS00021ED942_559292 33790014 0030533 0006412 559292 agcgccgugacgcaguggaagcgcgcagggcucauaacccugauguccucggaucgaaaccgagcggcgcuacca <<<<<<<...<<<.......>>>.<<<<<<.......>>>>>.>...<<<<<.......>>>>>>>>>>>>.... (((((((...(((....[..)))..(((((.......))))).....(((((..]....)))))))))))).... Structure of the yeast Gcn1 bound to a colliding stalled 80S ribosome with MBF1, A/P-tRNA and P/E-tRNA; tRNA (75-MER) 7nrd Sm 77 4.36 RF00005 URS000041AF00_559292 33790014 0030533 0006412 559292 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(.(((..]....))).)))))))..... Structure of the yeast Gcn1 bound to a colliding stalled 80S ribosome with MBF1, A/P-tRNA and P/E-tRNA; tRNA (77-MER) 7nrd LA 3184 4.36 RF02540,RF02543 URS0000A7632E_559292 33790014 0003735 0005840 559292 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........................<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<<.<<<<<<<<<<<<<<<<<<<<.....<<<<......>>>>.(.......<<<......)>>>....>>>>>>>>>..>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<.........................<<<<<<<.<<<<<<<<<<<<<<<......<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>...>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<....<....>....>>>.>>>.>>....>>>>>>.>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<....<<.<<<<<<<.....<<<....<<<..<.<<<<...<<<<<<.....>>>>>>.>>>>.>..>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>..>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>>..<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<<....<<<....>>>...<...<<<<<<...<<<<.<<<<<<<<<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<<....>>>>>>>>>>>>.>.>>>>>>>.>>>>.........>>>>>>...>.....>>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<....<....>.....>>>>><<.<<<<<<<<<<<....>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.....<<.....<<<<....>>>>.....>>..>>>>..>>>>>.<<<<.........>>>>.........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>.....[[[[..{{{.{{......[[[[.{{.[[[..<<<<<.<<<<<<<<..<<<<<<<<<<<<<<<<......>>>>>>.>>>>>>>>>>...<<<<<.....<<<<..<<<<........>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]...}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]].....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<.<..<<<<<......>>>>>..>>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((.(((...))).)).))....)........((.(((...(((.(((((((((((((.(...({((((......)))))[[(...).(((....}]])))....).))))))..))))))).....)))..))).))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((.(....).))............).....................(((((.(.(.((......(...............).(((((((((((((.(((((((((.......(((.(((......((((.((..)).)))).......))).))).....))))).)))).)))))........(((....)))....))))))))....)).).).))))).<((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((.(((..(((....(((((((....)))))))....<)))...(((..((.((.......A)))).)))....))).))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).).(((((((((....((.(((((((.....(((....(((..(.((((...((((((.....)))))).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).)...((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((.(((....(.........)....))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.(.((((((.((......((((.((((....))))))))...)))))))).)..).....))))))((.....((.....((((((.......))))))((((.....((((..((...((((((...((.....)).))))))....[[(((.((...((....(((....))).........(((.((.....).).)).)....))....))...(((((........)))))]]((((..(((((((...((((....)))...(.[[((((((...((((.(((.(((((.((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))).).).))).))).))))(...)....))))))...))....))))..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.((((((((((.(...)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(.(((.........))).)........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..((((..((((((((..(((((((.(((((.((......)).))).)).)))))))....((((.....((((..((((........))))..........]]...((((((....))))))..))))..))))......))))))))...))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((...(..(((((...((.......))...)))))....)..).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a.))..))).))))).....(((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....))))))).......(((((((.(((.((....((.(........(((((((..).)))))).....))).......((.(((...(((.(.(..(((......)))..).).))).))).)).............)).))).)))))).)(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(((.((..)..).)))..)))))...)))....)))).)))))).))))).. Structure of the yeast Gcn1 bound to a colliding stalled 80S ribosome with MBF1, A/P-tRNA and P/E-tRNA; 25S rRNA (3184-MER) 7nrd LB 121 4.36 RF00001 URS000055688D_559292 33790014 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (.(((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(.(((..((....)).))).).....))))))))))))).). Structure of the yeast Gcn1 bound to a colliding stalled 80S ribosome with MBF1, A/P-tRNA and P/E-tRNA; 5S rRNA (121-MER) 7nrd LC 158 4.36 RF00002 URS00001BF64E_559292 33790014 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... ..........................................(((((.[[.....))).....(.((((.....]]............).)))..)...)).....((.....))(((((((((....)))))))))..................... Structure of the yeast Gcn1 bound to a colliding stalled 80S ribosome with MBF1, A/P-tRNA and P/E-tRNA; 5.8S rRNA (158-MER) 7nsi AA 960 4.6 RF00177,RF01959 URS00000CFF65_9823 33878294 0003735 0005840 9823 acagguuugguccuggccuuucuauuaauucuuaauaaaauuacacaugcaaguauccgcgccccggugagaaugcccuccagaucuuaaagaucaaaaggagcagguaucaagcacaccuauaacgguagcucauaacgccuugcucaaccacacccccacgggaaacagcagugauaaaaauuaagccaugaacgaaaguuugacuaaguuauauuaauuagaguugguaaaucucgugccagccaccgcggucauacgauuaacccaaauuaauagauccacggcguaaagaguguuuaagaaaaaaaaucacaauagaguuaaauuauaacuaagcuguaaaaagcccuaguuaaaauaaaauaacccacgaaagugacucuaauaauccugacacacgauagcuaggacccaaacugggauuagauaccccacuaugccuagcccuaaacccaaauaguuacauaacaaaacuauucgccagaguacuacucgcaacugccuaaaacucaaaggacuuggcggugcuucacauccaccuagaggagccuguucuauaaucgauaaaccccgauagaccuuaccaacccuugccaauucagccuauauaccgccaucuucagcaaacccuaaaaaggaacaauaguaagcacaaucauagcacauaaaaacguuaggucaagguguagcuuauggguuggaaagaaaugggcuacauuuucuacauaagaauauccaccacacgaaaguuuuuaugaaacuaaaaaccaaaggaggauuuagcaguaaaucaagaauagagugcuugauugaauaaggccaugaagcacgcacacaccgcccgucacccuccucaagcauguaguaauaaaaauaaccuauauucaauuacacaaccaugcaagaagagacaagucguaacaagguaagcauacuggaaagugugcuuggauuacc ..((((..<<<<<<.)))).<<<<<<<<<..<<<<<<<<..<.<<<.<<<..<<....>>......<<......<<<<<...<<<<<...>>>>>...>>>.>>.<<<....<<...<<<......>>>..>>......>>>..<.....>.>>.<<<....>>>.....>>>>>>>.........<<...<<<<<....>>>>.>>>...>>.>>>>>>...<.<<<<<<.....(((.....((.>>>)).......)))..>>>.>..>>>>>>>>>.....<<<((.....<<<<...<<..............<<<<<<.....<.<<<<<<.<<<......>>>..>>>>>>..>..........<<<....>>>>>>>>>......>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<......))...>>>>>>.>>>.<<<........<<....>>......>>>..>>>>>><<<<<.<<<<<.....<<..<<<<<.<<<<<<<<<<<.....<<........>>..........<<<<<<<..........<<<.<<<..<<<<<<.......<<..<<<<<....>>>.......>>..>>......<<.....>>..........>>>...>>>>>>>>>...>>>>>>>..>>.>>>>>>>>.>...<<<<.....>>>>...........<....<<<<<<<......>>>>>>>....>.....>>>>>.....<<<<<<<.........>>>>>>>......>>.....>>>>>>>>.>>....<..<<.<...<<<.<<..<<<<<..<<<<<...<<<<.....>>>>..>>>>>.....>>>>>..>>.>>>....>.>>...>.....<<<<<<<<<....>>>>>>>>>........ [.[[[[...((((..]]]]].((((((((..((((((((..(.(((.(((..((....))......(((.....(((((...((((.....))))...))).)).(((....((..((((......))).)))......)))..(.....)))).(((....))).....)))))))......(..((...(((((....)))).))).).)).))))))...(.((([[[.....(((.....((.]]])).......)))..))).)..))))))))......((([[...(.((((...((..............(((((((......((((((.((........))..))))))......).....(.((....)))))))))......))...))))....((((((...((...((((.........))))...))))))))......{...(((((((.....]]..))))))))))).(((........((....))......)))...)))).(((((.(((((.....((..(((((..((((((((((.....((........))..........(((((((..(......).((.(((...((((((.(....((..(((((....))).......))..))......((.....))......).).)))...)).)))))....)))))))..)).)))))))).(...((((.....))))...........(....(((((((......)))))))....)..)..))))).....(((((((.........)))))))......)).....)))))))).))..(.(..((.(...(((.((..(((((..(((((...(((.......)))..))))).....)))))..)).)))....).))...)..)..(((((((((....)))))))))}....... 55S mammalian mitochondrial ribosome with mtRRF (pre) and tRNA(P/E); 12S rRNA 7nsi AV 71 4.6 URS00023119AA_9823 33878294 9823 uuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuucca ....................................................................... ....................................................................... 55S mammalian mitochondrial ribosome with mtRRF (pre) and tRNA(P/E); tRNA (P/E) 7nsi BA 1544 4.6 RF02541,RF02540 URS000022E3AE_9823 33878294 0003735 0005840 9823 accaaagcuagcucaacauacuaaacaaauacaaaaauacaccaaaauaaaauaaaacauucaccuaacauuaaaguauaggagauagaaauuuuuauccugacgcuauagagauaguaccguaagggaaagaugaaagaauaaaauaaaaguaaaaaaaagcaaagauuaccccuucuaccuuuugcauaaugguuuaaccagaaaaaaucuaacaaagagaacuuuagcuagauaccccgaaaccagacgagcuacccaugagcaguuuaaaagaaccaacucaucuauguggcaaaauagugagaagacuuguagguagaggugaaaagccuaacgagccuggugauagcugguuguccgagaaagaauuuuaguucaaccuuaaaaauaccccaaaaacccuaaauuccaauguauuuuuaagagauagucuaaaaagguacagcuuuuuagaaacggauacaaccuugacuagagaguaaaaucuuaauacuaccauaguaggccuaaaagcagccaucaauugagaaagcguuaaagcucaacaaauucaccaacauaaucccaaaaacuaauaacaaacuccuagcccaauaccggacuaaucuauugaaacauagaagcaauaauguuaauaugaguaacaagaagccuuucuccucgcacacgcuuacaucaguaacuaauaauauacugauaauuaacaaccaauaaaccaaaacaacacuaaaacguuuauuaauuacauuguuaacccaacacaggagugcaccaaggaaagauuaaaagaaguaaaaggaacucggcaaacacaaaccccgccuguuuaccaaaaacaucaccucuagcauuacuaguauuagaggcaaugccugcccagugacaccaguuuaacggccgcgguauucugaccgugcaaagguagcauaaucacuuguucuccaaauaaggacuuguaugaauggccacacgaggguuuuacugucucuuacuuccaaucagugaaauuaaccuucccgugaagaggcgggaauaaaaaaauaagacgagaagacccuauggagcuuuaauuaacuauuccaaaaguuaauaacuuaacauggacuagcaauuucgguuggggugaccucggaguacaaaaaacccuccgagugauuuuaaucuagacaaaccagucaaaauaaccauaacaucacuuauugauccaaaauuuugaucaacggaacaaguuacccuagggauaacagcgcaauccuguucuagaguuccuaucgacaauaggguuuacgaccucgauguuggaucaggacacccaaauggugcaaccgcuauuaaagguucguuuguucaacgauuaaaguccuacgugaucugaguucagaccggagcaauccaggucgguuucuaucuauuauaaauuucucccaguacgaaaggacaagagaaaugggaccaaccucacaaacgcgucucagagauaauuaaugauuuaaucuuaaccuaauuaacucauaauaaauccagcccuagaacagggcaca <<.<......<<<<.......................................<......>...........<.....<<.....>>....>.........>>.>>.............<<....>>...................>....>>...........<<<.......>>>...<.<........>.>..<<<<<........<<<<<.<..<<....>>...>.>>>>>..<<.<..<<<<<.<.....<<<.<<<<<..<<<......>>>...<<<..<<<<........>>>>.>>>....>>>>>.>>>...<<<.....>>>......>.>>>>...>..>.>>..<<<<<.....<<<<....>>>>..<<<<<<<<<<<<.....<<........>>.....>>>>>>>>>>>.>....<<<<<<<<<......>>>>>>>>>...<<......>>....<<<<.<<<...................<....<<<.........>>>....>.......<<<......>>>........................................>>>>>>>........>>>>>...<<<<<......>>>>>.........>>>>>.<......<<..<<<....>>><<<..<<<<........<<<<<....<<....>>..>>>>>......<<<..<<<<<<<.................>>>>>>>.......>>>.....<<......>>.>>>>.....>>>..<<<<....<<<<<<<.<<...............<<<<<<<<..<<<.........>>>...<<<<<<.............>>>>>>...<<<<.<<<..<<<<<....>>>..>>>>><<<<<<......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>.>..>>.>>>>>>......>>.>>>>>>>.>>>>.>>.....>.....<<<<<........>>>>>.......<<<.<<<.<<......<<<<.<<<<<<..<<<<..<<<.<<<<.<<<<<<.>>>>>>....>>>>.>>>.>>>>..<<<<.....>>>><<<<<<...........>>>>>>.<<<<....<<...<<<......>>>...>>.........>>>>..........<<<....>>>............>>>>..>>>>>>.......<<<..<.<<<<<<...<<.......>>...>>>>>>...>.>>.>.......<<<<<.<<<<<<..<<.<<<<<<......>>>>>>...>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>>>>.<<.<<<<<<<.................>>>>>>><<<<<...<.........>.>>>>>.<<<...<<<<.................>>>>...>>>.>>.........<<<<.......>>>>... ((.(...(..((((.......................................(...[..)........(..(.....((.]...))....)..)......)).)).............((....))....)..............)....))...........(((.......))).[.(.(........).)..(((((........(((((.(..((....))...).)))))..((.(...((((.(.....(((.((((((.(((.....[)))...(((..((((.......{)))).)))..).))))).))).(.((.......))...)..).))))......).))..(((((.....((((....))))...(((((((((((.....((........)).....)))))))))))......(((((((((......)))))))))...((......))....((((.(((...................(.(..(((.........)))..).)....(..(((......)))).......................................)))))))........)))))...(((((......))))).........))))).(......((..((((..))))(((..((((......(.(((((....((....))..)))))......(((..(((((((...........(..)..))))))).......))).)...((......)).)))).....)))..((((....(((((((.((..(....(.......((((((((.].((.........))....((((((.............))))))...((((.(((..(((((....)))..)))))(((((........)))))........((..........(((((.......)))))..)..)....))).)..)).))))))..)..))).))))))).)))).)).....)..{..(((((.....]}.))))).......(((.(((.((......((((.((((((..((((..(((.((((.((((((.))))))....)))).))).))))..(((......[)))((((((..........]))))))((((((..)((.(.(((...[..))))..)).........))))..........(((....))).....)].....))))..))))))......((((..(.(((.((...((.......))...)).)))...).)).).)......((((.((((((..((.((((((......))))))...)).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..}.))..)))))).((.(((((((......(....).....)))))))(((((...(.(.....).).))))).(((....(((.................)))....))).)).........((((.......))))... 55S mammalian mitochondrial ribosome with mtRRF (pre) and tRNA(P/E); 16S rRNA 7nsj AA 960 3.9 RF00177,RF01959 URS00000CFF65_9823 33878294 0003735 0005840 9823 acagguuugguccuggccuuucuauuaauucuuaauaaaauuacacaugcaaguauccgcgccccggugagaaugcccuccagaucuuaaagaucaaaaggagcagguaucaagcacaccuauaacgguagcucauaacgccuugcucaaccacacccccacgggaaacagcagugauaaaaauuaagccaugaacgaaaguuugacuaaguuauauuaauuagaguugguaaaucucgugccagccaccgcggucauacgauuaacccaaauuaauagauccacggcguaaagaguguuuaagaaaaaaaaucacaauagaguuaaauuauaacuaagcuguaaaaagcccuaguuaaaauaaaauaacccacgaaagugacucuaauaauccugacacacgauagcuaggacccaaacugggauuagauaccccacuaugccuagcccuaaacccaaauaguuacauaacaaaacuauucgccagaguacuacucgcaacugccuaaaacucaaaggacuuggcggugcuucacauccaccuagaggagccuguucuauaaucgauaaaccccgauagaccuuaccaacccuugccaauucagccuauauaccgccaucuucagcaaacccuaaaaaggaacaauaguaagcacaaucauagcacauaaaaacguuaggucaagguguagcuuauggguuggaaagaaaugggcuacauuuucuacauaagaauauccaccacacgaaaguuuuuaugaaacuaaaaaccaaaggaggauuuagcaguaaaucaagaauagagugcuugauugaauaaggccaugaagcacgcacacaccgcccgucacccuccucaagcauguaguaauaaaaauaaccuauauucaauuacacaaccaugcaagaagagacaagucguaacaagguaagcauacuggaaagugugcuuggauuacc ..((((..<<<<<<.)))).<<<<<<<<<..<<<<<<<<..<.<<<.<<<..<<....>>......<<......<<<<<...<<<<<...>>>>>...>>>.>>.<<<....<<...<<<......>>>..>>......>>>..<.....>.>>.<<<....>>>.....>>>>>>>.........<<....<<<<....>>>>..>>...>>.>>>>>>...<.<<<<<<.....(((.....((.>>>)).......)))..>>>.>..>>>>>>>>>.....<<<((.....<<<<...<<..............<<<<<<.....<.<<<<<<.<<<......>>>..>>>>>>..>..........<<<....>>>>>>>>>......>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<......))...>>>>>>.>>>.<<<........<<....>>......>>>..>>>>>><<<<<.<<<<<<<...<<..<<<<<.<<<<<<<<<<<.....<<........>>..........<<<<<<<..........<<<.<<<..<<<<<<.......<<..<<<<<....>>>.......>>..>>......<<.....>>..........>>>...>>>>>>>>>...>>>>>>>..>>.>>>>>>>>.>...<<<<.....>>>>...........<....<<<<<<<......>>>>>>>....>.....>>>>>.....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<...<<<.<<..<<<<<..<<<<<...<<<<.....>>>>..>>>>>.....>>>>>..>>.>>>....>.>>...>.....<<<<<<<<<....>>>>>>>>>........ [.[[[[...((((..]]]]].((((((((..((((((((..(.(((.(((..((....))......(((.....(((((...(((((...)))))...))).)).(((....((..((((......))).)))......)))..(.....)))).(((....))).....)))))))......(..((...(((((....)))).))).).)).))))))...(.((([[[.....(((.....((.]]])).......)))..))).)..))))))))......((([[...(.((((...((..............(((((((......((((((.((........))..))))))......).....(.((....)))))))))......))...))))....((((((...((...((((.........))))...))))))))......{...(((((.(.....]]..).))))))))).(((........((....))......)))...)))).(((((.(((((((...((..(((((..((((((((((.....((........))..........(((((((..(......).((.(((...((((((.(....((..(((((....))).......))..))......((.....))......).).)))...)).)))))....)))))))..)).)))))))).(...((((.....))))..(.....)..(....(((((((......)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(...(((.((..(((((..(((((...(((.......)))..))))).....)))))..)).)))....).))...)..)..(((((((((....)))))))))}....... 55S mammalian mitochondrial ribosome with tRNA(P/P) and tRNA(E*); 12S rRNA 7nsj BA 1544 3.9 RF02541,RF02540 URS000022E3AE_9823 33878294 0003735 0005840 9823 accaaagcuagcucaacauacuaaacaaauacaaaaauacaccaaaauaaaauaaaacauucaccuaacauuaaaguauaggagauagaaauuuuuauccugacgcuauagagauaguaccguaagggaaagaugaaagaauaaaauaaaaguaaaaaaaagcaaagauuaccccuucuaccuuuugcauaaugguuuaaccagaaaaaaucuaacaaagagaacuuuagcuagauaccccgaaaccagacgagcuacccaugagcaguuuaaaagaaccaacucaucuauguggcaaaauagugagaagacuuguagguagaggugaaaagccuaacgagccuggugauagcugguuguccgagaaagaauuuuaguucaaccuuaaaaauaccccaaaaacccuaaauuccaauguauuuuuaagagauagucuaaaaagguacagcuuuuuagaaacggauacaaccuugacuagagaguaaaaucuuaauacuaccauaguaggccuaaaagcagccaucaauugagaaagcguuaaagcucaacaaauucaccaacauaaucccaaaaacuaauaacaaacuccuagcccaauaccggacuaaucuauugaaacauagaagcaauaauguuaauaugaguaacaagaagccuuucuccucgcacacgcuuacaucaguaacuaauaauauacugauaauuaacaaccaauaaaccaaaacaacacuaaaacguuuauuaauuacauuguuaacccaacacaggagugcaccaaggaaagauuaaaagaaguaaaaggaacucggcaaacacaaaccccgccuguuuaccaaaaacaucaccucuagcauuacuaguauuagaggcaaugccugcccagugacaccaguuuaacggccgcgguauucugaccgugcaaagguagcauaaucacuuguucuccaaauaaggacuuguaugaauggccacacgaggguuuuacugucucuuacuuccaaucagugaaauuaaccuucccgugaagaggcgggaauaaaaaaauaagacgagaagacccuauggagcuuuaauuaacuauuccaaaaguuaauaacuuaacauggacuagcaauuucgguuggggugaccucggaguacaaaaaacccuccgagugauuuuaaucuagacaaaccagucaaaauaaccauaacaucacuuauugauccaaaauuuugaucaacggaacaaguuacccuagggauaacagcgcaauccuguucuagaguuccuaucgacaauaggguuuacgaccucgauguuggaucaggacacccaaauggugcaaccgcuauuaaagguucguuuguucaacgauuaaaguccuacgugaucugaguucagaccggagcaauccaggucgguuucuaucuauuauaaauuucucccaguacgaaaggacaagagaaaugggaccaaccucacaaacgcgucucagagauaauuaaugauuuaaucuuaaccuaauuaacucauaauaaauccagcccuagaacagggcaca <<.<......<<<<.......................................<......>...........<.....<<.....>>....>.........>>.>>.............<<....>>...................>....>>...........<<<.......>>>...<.<........>.>..<<<<<........<<<<<.<..<<....>>...>.>>>>>..<<.<..<<<<<.<.....<<<.<<<<<..<<<......>>>...<<<..<<<<........>>>>.>>>....>>>>>.>>>...<<<.....>>>......>.>>>>...>..>.>>..<<<<<.....<<<<....>>>>..<<<<<<<<<<<<.....<<........>>.....>>>>>>>>>>>.>....<<<<<<<<<......>>>>>>>>>...<<......>>....<<<<.<<<...................<....<<<.........>>>....>.......<<<......>>>........................................>>>>>>>........>>>>>...<<<<<......>>>>>.........>>>>>.<......<<..<<<....>>><<<..<<<<........<<<<<....<<....>>..>>>>>......<<<..<<<<<<<.................>>>>>>>.......>>>.....<<......>>.>>>>.....>>>..<<<<....<<<<<<<.<<...............<<<<<<<<..<<<.........>>>...<<<<<<.............>>>>>>...<<<<.<<<..<<<<<....>>>..>>>>><<<<<<......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>.>..>>.>>>>>>......>>.>>>>>>>.>>>>.>>.....>.....<<<<<........>>>>>.......<<<.<<<.<<......<<<<.<<<<<<..<<<<..<<<.<<<<.<<<<<<.>>>>>>....>>>>.>>>.>>>>..<<<<.....>>>><<<<<<...........>>>>>>.<<<<....<<...<<<......>>>...>>.........>>>>..........<<<....>>>............>>>>..>>>>>>.......<<<..<.<<<<<<...<<.......>>...>>>>>>...>.>>.>.......<<<<<.<<<<<<..<<.<<<<<<......>>>>>>...>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>>>>.<<.<<<<<<<.................>>>>>>><<<<<...<.........>.>>>>>.<<<...<<<<.<............>..>>>>...>>>.>>.........<<<<.......>>>>... ((.(...(..((((.......................................(...[..)........(..(.....((.]...))....)..)......)).)).............((....))....)..............)....))...........(((.......))).[.(.(........).)..(((((........(((((.(..((....))...).)))))..((.(...((((.(.....(((.((((((.(((.....[)))...(((..((((.......{)))).)))..).))))).))).(.((.......))...)..).))))......).))..(((((.....((((....))))...(((((((((((.....((........)).....)))))))))))......(((((((((......)))))))))...((......))....((((.(((...................(.(..(((.........)))..).)....(..(((......)))).......................................)))))))........)))))...(((((......))))).........))))).(......((..((((..))))(((..((((......(.(((((....((....))..)))))......(((..(((((((...........(..)..))))))).......))).)...((......)).)))).....)))..((((....(((((((.((..(....(.......((((((((.].((.........))....((((((.............))))))...((((.(((..(((((....)))..)))))(((((........)))))........((..........(((((.......)))))..)..)....))).)..)).))))))..)..))).))))))).)))).)).....)..{..(((((.....]}.))))).......(((.(((.((......((((.((((((..((((..(((.((((.((((((.))))))....)))).))).))))..(((......[)))((((((..........]))))))((((((..)((.(.(((...[..))))..)).........))))..........(((....))).....)].....))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......((((.((((((..((.((((((......))))))...)).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..}.))..)))))).((.(((((((......(....).....)))))))(((((...(.(.....).).))))).(((....(((.................)))....))).)).........((((.......))))... 55S mammalian mitochondrial ribosome with tRNA(P/P) and tRNA(E*); 16S rRNA 7nsj AV 71 3.9 URS00023119AA_9823 33878294 9823 uuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuucca ....................................................................... ....................................................................... 55S mammalian mitochondrial ribosome with tRNA(P/P) and tRNA(E*); tRNA(P/P) and tRNA(E*) 7nsj AY 71 3.9 URS00023119AA_9823 33878294 9823 uuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuucca ....................................................................... ....................................................................... 55S mammalian mitochondrial ribosome with tRNA(P/P) and tRNA(E*); tRNA(P/P) and tRNA(E*) 7nso A 2903 2.9 RF02540,RF02541 URS000080E25C_562 34294725 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<<..>>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<<.<<....>>..>>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((.(((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))))))).)))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((.(((.....))).).))...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{..((((.(((..((((.......))))..))).....(..(((......)))).))))....)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..(((((.((((((...{{{.).))))).((..(((....((((((((((((.((.....))))))))))..))))..[.)))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((....((((..)])))....)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((.........((((..((....))...)))).........))))))))..)))))(((((.........)))))........((.(......).(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((.(.(..(.(.........(...(............((((.(......).))))...................)...)).)..).).)))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....((.((((....))).).))..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Structure of ErmDL-Erythromycin-stalled 70S E. coli ribosomal complex with P-tRNA; 23S rRNA (2903-MER) 7nso B 120 2.9 RF00001 URS0000049E57_562 34294725 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Structure of ErmDL-Erythromycin-stalled 70S E. coli ribosomal complex with P-tRNA; 5S rRNA 7nso 8 87 2.9 RF00005 URS00004630EA_562 34294725 0030533 0006412 562 gccgaggugguggaauugguagacacgcuaccuugaggugguagugcccaauagggcuuacggguucaagucccguccucgguacca <<<<<<<..<<<...........>>><<<<<<.......>>>>>><<<<....>>>>..<<<<<.......>>>>>>>>>>>>.... (((((((..(((......[....))).(((((.......))))).((((....))))..(((((..]....)))))))))))).... Structure of ErmDL-Erythromycin-stalled 70S E. coli ribosomal complex with P-tRNA; PtRNA-Leu 7nso a 1540 2.9 RF00177,RF01959,RF01960 URS0000D56C37_562 34294725 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<<....>>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<......>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<..<.<<<<<<<........>>>>>>>>...>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((((((((..)))))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))...((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..((.......))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Structure of ErmDL-Erythromycin-stalled 70S E. coli ribosomal complex with P-tRNA; 16S rRNA (1540-MER) 7nsp A 2903 3.5 RF02540,RF02541 URS000080E25C_562 34294725 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<<..>>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>...[.....<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))....].]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>.>........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<<.<<....>>..>>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<.<<...<<<......<<<<<<<<....>>>>>>>>...>>>.............>>.>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((.(((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))))))).)))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((...(((((....)))))...)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..(((.......))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.(((....((...((.....))....))....))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{..((((.(((..((((.......))))..)))........(((......)))..))))....)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((.(((((....))))).))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..(((((.((((((...{{{.).))))).((..((((...(((((..(((((.((.....)))))))..)..))))...))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((....((((..).)))....)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((.(..(((.(.(.............(...((.......((((((......))))))....)).............)....).).)).)..))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).(.][.[[[.)....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....((.((((....))).).))..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Structure of ErmDL-Erythromycin-stalled 70S E. coli ribosomal complex with A and P-tRNA; 23S rRNA 7nsp B 120 3.5 RF00001 URS0000049E57_562 34294725 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<...<...<<<<<<<<...>>>>>>>>.....>.>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((.(((((...))))).)).......))...)))))))))). Structure of ErmDL-Erythromycin-stalled 70S E. coli ribosomal complex with A and P-tRNA; 5S rRNA 7nsp 8 87 3.5 RF00005 URS00004630EA_562 34294725 0030533 0006412 562 gccgaggugguggaauugguagacacgcuaccuugaggugguagugcccaauagggcuuacggguucaagucccguccucgguacca <<<<<<<..<<<...........>>><<<<<<.......>>>>>><<<<....>>>>..<<<<<.......>>>>>>>>>>>>.... (((((((..(((......[....)))((((((.......))))))((((....))))..(((((..]....)))))))))))).... Structure of ErmDL-Erythromycin-stalled 70S E. coli ribosomal complex with A and P-tRNA; P-tRNA (leu) 7nsp a 1540 3.5 RF00177,RF01959,RF01960 URS0000D56C37_562 34294725 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<<....>>>>>>>.>>>.>..>>>>>......<<..<....<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<......>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>>>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>............ ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(.(..((.((..(((.(((((((..)))))))..)))))..))).)......(((.......((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....))).....(((((..((....)))))))..)))))))..)).)))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((.(.........)))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((..((...((((.((((.......)))).))).)...)..).)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((...((((((....))))))....((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....))))))))..)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((...(((((((((((....((((((.((((..((....)).))))))))))...)))))))))))...))).))))..).))...)..)..(((((((((....)))))))))}........... Structure of ErmDL-Erythromycin-stalled 70S E. coli ribosomal complex with A and P-tRNA; 16S rRNA 7nsp v 77 3.5 RF00005 URS0000349C05_562 34294725 0030533 0006412 562 gcauccguagcucagcuggauagaguacucggcuacgaaccgagcggucggagguucgaauccucccggaugcacca <<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((...(((.........)))..(((((.......))))).....(((((.......)))))))))))).... Structure of ErmDL-Erythromycin-stalled 70S E. coli ribosomal complex with A and P-tRNA; A-tRNA (Arg) 7nsq A 2903 3.1 RF02540,RF02541 URS000080E25C_562 34294725 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<<..>>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<<..>>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<<.....>>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.......<<<<<<.<<....>>..>>>>>>.......>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<..<...<<........<<<<<<<....>>>>>>>.....>>.............>..>...>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((.(((((.(((.(((...(((((......)))))[[(...).(((.....]])))...)))...))).))))).)))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((..(((.....)))...))...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.((...((((.......))))...))........(((......)))..)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((.(......).(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((.(.((.(.(.........(...(.............((..(......)..))....................)...))..))).).)))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....((.((((....))).).))..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Structure of ErmDL-Telithromycin-stalled 70S E. coli ribosomal complex with A and P-tRNA; 23S rRNA 7nsq B 120 3.1 RF00001 URS0000049E57_562 34294725 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Structure of ErmDL-Telithromycin-stalled 70S E. coli ribosomal complex with A and P-tRNA; 5S rRNA 7nsq 8 87 3.1 RF00005 URS00004630EA_562 34294725 0030533 0006412 562 gccgaggugguggaauugguagacacgcuaccuugaggugguagugcccaauagggcuuacggguucaagucccguccucgguacca <<<<<<<..<<<...........>>><<<<<<.......>>>>>><<<<....>>>>..<<<<<.......>>>>>>>>>>>>.... (((((((..(((......[....)))((((((.......))))))((((....))))..(((((..]....)))))))))))).... Structure of ErmDL-Telithromycin-stalled 70S E. coli ribosomal complex with A and P-tRNA; PtRNA (Leu) 7nsq a 1540 3.1 RF00177,RF01959,RF01960 URS0000D56C37_562 34294725 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<<....>>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((((....))))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....(((.((((.......)))).))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))...((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Structure of ErmDL-Telithromycin-stalled 70S E. coli ribosomal complex with A and P-tRNA; 16S rRNA 7nsq v 77 3.1 RF00005 URS0000349C05_562 34294725 0030533 0006412 562 gcauccguagcucagcuggauagaguacucggcuacgaaccgagcggucggagguucgaauccucccggaugcacca <<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.........)))).(((((.......))))).....(((((.......)))))))))))).... Structure of ErmDL-Telithromycin-stalled 70S E. coli ribosomal complex with A and P-tRNA; AtRNA (Arg) 7nwg 51 3626 3.8 RF02540,RF02543 URS0002311A0B_9986 34157102 0003735 0005840 9986 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggaaauguggcguacggaagacccacuccccggcgccggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcgcgguccggccgugccggcggggcggaucucccgcucccgucggcgggggaccgccccccggccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggccccggcggggaagguggcccgggggccccggguguuacagccccgccccggcagcagcagcucgccgaaucccggggccgagggagcgagacccgugcgccgcgcucuccccccucgggggggccgggccaccccucccacggcgcgaccgcucucccacccggggggcggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccgggggagguucucucggggccacgcgagcgcacggggucggcggcgaugucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcuacgaaagccgccguggcgcaaugaaggugaaggccggcggcgcgccgccggccgaggugggaucccgaggccuuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcgaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccaaaguuucccucaggauagcuggcgcucuccgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcugguguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggaugguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgcuggcagucggcagagcgagaaagagaguggcgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucagccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcuggcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacaugagagguguagaauaagugggaggcccgggccgccggugaaauaccacuacucugaucguuuuuucacugacccggugaggcgggggggcgagccgggcucucgcuucuggcgccaagcgcccggccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauagcgccggagccucgguuggccucggauagccggucccccgcccgggguccggugcggagagcccuucgucccgggaaacggggcggccggaaagggggccgcccucucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcugcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..[[[..<.<<<...<<<.<<<<<<<...>>>>>>>..>>>.....>>>.>..<<<<<<<<<....<<<..<<<..<<<<<<<<....<<<.<.....>>>>.....((......<<<.....))>>>...>.>>>>>>>...>>>..>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<......>>>..................................<<<<<<<<..<<<.<....<<<<<<<<.........<<<<<<<<<<....<<<<<<<.<<<...<<<<<<<.<<<<<<<<<......>>>>>>>>>>>>>>>>..>>>>>>>...>>>.>>>>>>>>>>..........>>>.>>>>>...<<<<<<<.<<<<<<<<<<.<<<<.........<..<<<<<<<......<<<<<<<<.>>>>>>>>.......>>>>>>>...>............>>>>...>>>>>>>>>>.....<.........>.........<...<<<<<<..>>>>>>.....<<..<<<.<<<<<<<<<<<<<<<<....<..<<..>>.>.<<<<<<<.<<........>>.>>>>>>>.>>>.>>>>>>>>>>.>>>...>>>.............>>.........>.........>>.>>>>>....>>>>...>>>>>>>>...<<<........>>>.<<<<<<....<<<.<<<<<<<<<..<<<...<<<<.....>>>>.....>>>...<<....>>...<<<<<.<<<<..>>>>.>>>>>..<<<<<...<<<..<<........[...>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>.>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<.<<<<......>>>>.>.....>>>...<<<..<..<<........>>.>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<<....<<<....<<<....<<<..<<<<.............>>>>>>>....>>>...>>>....>>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>>>>>>.>>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<..<<<.........<<<.........<<.........>>...............<<......>>.....>>>.....>>>..>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<.....................]................>>>>>>>>>....>>>>>>.<<<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>.>>.....>>>>>><<<....<<.....<<<<<<.......>>>>>>.<<<......<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>.............<<<<<<<<<...>>>>>>>>>........>>....>>>..<<<<<........>>>>>))<<<<....<<<......<<<<<......>>>>>....<<<....>>>.......<<<<<<...<<<<<<<<<<<<<<<<<<<<<<<..{{{..>>>>>>.....<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>......<<<<<<<.......>>>>>>>>>>>.>.>>>>>>>>>>>>.........>>>>>>.................>>>.>>>>.>>>..>>.....<<......>>>>>>..<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<...............<<<<<...............>>>>><<.<<<<<<<<<<<.>>>>>..>>>>>>.>>............<<<<<<<<<..<<...........>>..<<<<<<<....<<<<.....>>>>......>>>>>>>....<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>>...<<.........>>...........<...........<<<<<.......>>>>>.....>.....>.....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>...>>>....<<<<..........>>>>.....[[[[..{{{.{{......[[[[....[[[..<<<<..<<<<<<<<<.<<<<<<....<<.<<<<..........<<<.<...<<<..>>>.............>.>>>.>>>>.>>.....>>>>>>...<<<<<.....<<<<.....<........>..................<<<<<<<<..>>>>>>>>...>>>>..>>>>>....>>>>>>>>>...>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))]......((((((..(((..>>>>>>.)))))))))..........]]].....]]]].......<<.<.<.<<<<<<...<.........>...>>>>>>...>>.>.>.......<<<<<.<<<<<...<...<<<<<......>>>>>.....>.<<<.........>>>......>>>>..>...>>>.>>....<<<.<<<....>>>..>>>....}}..}}}.]]]]......<<<<<<....<<<..<.<<<<<.................>>>>>.><<<<.....<<<....<<..<.<<<.}}}..>>>....>.>>...>>>....>>>><<<<....<<<<.............>>>>....>>>>.>>>.....>>>>>>.<<<<<<<..<<<.....<<<........<<<<<<..<<<<..>>>>>.>>>>>.......>>>...<<<..<<<<....<<<.<<<<<........>>>>>..>>>...>>>>..>>>...............>>>..>>.>>>>>.<<<<<.<.............>....<<.<<<<<<<.<<.....<<<<.<..<<<<<.>>>>>..>>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................((((.......(...[..)........))).).........(......)...((.((.....((.]...)).....))))...((.(...(((..(.(.(((.(((.....).))))..)).....))))....(((((((((.....((.((((..(((((.((..(.((.((.....)))))....[[(...).(((.....]])))...).).)))))...))).)))....)))))))))........((((............))).)......(((...[.[[[[.)))...)))...................................(....).............(..((((....))))............)......................(((.(.(..(((.((...((((((((...(.....(.(((((((.....(((((((.((..(.(((((((.((.(((.....().....))).))))))))).).))))))...)))..))))))).)......)...))).)))))...((((((((.(((((.((((.(((...(.(......(((((((.........(.(((.).)).).........)))))))..............)))))...)))).))))).......(.....{.)........(...(.((((((..))))))...(.(..(.((.((.(((..((..(((.....(..(....).).(((((((....(....)....)))))))..).))..))..)))..))...))..)..(.....)....)).....)....).....))).)))))...)))))...).).)))..[(.(..........).)(((.((....((.(.(((...((..(((..(((((.....))))..)..)))....(....)....((((.(.((....))..)))))..(((((...(((...(........[[[..)..)))....)))))...((..(.(.((((......)))))..).)).......))...)))..)))...(.(...(((........(((.((.((..((((........................)<)))...((...((.((.......B))))..))....)).)).))).(...............).....)))......)..)..((((((....(..((....))..).(.(((.(((...(((.(.(..(((....(......((....((((..(((((...........)))))))).)...)).....)....)))..)...(((((((((.........))))))))).....))))))).)))..)...(((...((((.....))))...)))....(((......)))...((((.((...(.([[[...(.(.(((((......(..........(((..((............A.....(.......(...........)...............((......))....).............)).)))..........]]].)....)))))))).)...)).))))((...(.(((........}.........].]]................))))...))....)))))).((((((((((.(.......((((.((((....))))))))....))))))))).)).....)).)))((.....((.....((((((.......))))))..((......(.(..((.....((((....(.....)..))))......[[(((.((...((....(((....))).............(((((((((...)))))))))........))....))...(((.(.........))))]]((((....((......((.((........)).))...(((....))).........(((....((((..(((((((.(((((((((...{{..))))))....(((((.((((.((.......(((.....))).......))))))..))))).....(...(((.......)))...))))..).))))))..))))..........)))....................)).)))).)))..)).....((......)).).)....((.....))....)).....((((.....(((((((.(........(.......(((((......[........)))))((.(((((((((((.)))))..)))))).))(...).......((((..(((.>...(........).....((((......(((.......)))........))))..]..((...(..(...((.(....(.....((((....)))).....)..))).....).)..(.((.........))...)...................(((..(......).)))..........)).....)).)..)))).)....).)))))))..))))))....)).{..(..(......]}...).)......(((..(((.((.......((....(..(..(((((.(.(((((((.(((((........((((...........(.....((((()))))................).)))).........)))))....((((.....((((...(.(.......)...)...............((((((((..))))))))...))))..)).))....))))))).)..)))))..(((.......)).)..(..................)..[(....((.((((.(.((((((.......))))))...).((]..[[[))....))))..))(..((.(((((....{..)))).))).)(.(....).)..)]]].......((.(((..(((..]]].]].)))))).)).....}....)..).....))........((.(.(...((((...((.......))...)))).....)).).)........(.((.((((((..(...(((((......))))).....)..((.(.....).))......)))))..)...))..).....((.(..(....)....)))..b.))..))).))).......((((.(....(((....(((((......(....).....)))))..((((....((((....((...(((((}}..))))).....))...))))...)))).((......(.......a.........)......))..)))......))))).(((((((..((((....(((.........((((...(.((..)).)..))))........)))...(((..(((.....(((..((((........))))...)))....)))..)))..............))))..).)))))).(((((.(..(.......)..)....((...((((.........((((.(..((.((.)).))..)))))...........))).)...))..))))).. Mammalian pre-termination 80S ribosome with Hybrid P/E- and A/P-site tRNA's bound by Blasticidin S.; 28S Ribosomal RNA 7nwg 71 120 3.8 RF00001 URS000002B0D5_9986 34157102 0003735 0005840 9986 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu .<<<<<<......<<<<<<<......<<<<<.....<<...>>..>>>..>>.....>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>..>>>>>>... ..(...(......(((((((.........(((...(....)...)))..........))))).))((((((......((.(...((....))..).)).....))))))..)...).... Mammalian pre-termination 80S ribosome with Hybrid P/E- and A/P-site tRNA's bound by Blasticidin S.; 5S Ribosomal RNA 7nwg 81 151 3.8 RF00002 URS0000D56C3A_9986 34157102 0003735 0005840 9986 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcagguugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<.<<.....>>>.....(.<<<......>>........>>>..)...>>>....<<<..>>><<<<<<<<.......>>>>>>>>.................... .........................................((((((.[[.....))).......(((......]]........)))......)))....(......).(((((((.......)))))))..................... Mammalian pre-termination 80S ribosome with Hybrid P/E- and A/P-site tRNA's bound by Blasticidin S.; 5.8S Ribosomal RNA 7nwg A2 1740 3.8 RF01960,RF01959,RF00177 URS00023119DC_9986 34157102 0003735 0005840 9986 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucguacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucagaucaaaaccaacccggucaggcggcuuuggugacucuagauaaccucgggccgaucgcacgcccggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcgggcggccguccguccccugccucucggcgccccggggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgaccccggucggcguaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggugcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<...(((.>>>>><<<.<<<<<<...<.<<..<......<<..<<<..<<....<.......................>.>>......<<........<<<.<..........<<<...........<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<<......>>>>>...>>>><<..<<<<<.......(((.....<........>......<.....>..>>>>>......>>...<<<<..<.....>.>>>>....>>>.......>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>....<<.<<<<....>>>>....>>..>>.<<.<<.<.........>>>.>>...<<....>>.....>>>.>>.........<<<....<<<.....>>>..>>>..>...>>.>.....<<<.<<<<..<<<....>>>...>>>>..>>>......<<..<...........>..>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>.>>>...........<[[.....<.<<...<<<.<<....<<<.<<<<.<<..>>.>>>>.>>>....<........<<..>.>.....>....<<<<<<.<.......<<...<.......>.<<<<.>>>>...>>......>.>>>..>>>..........<<.<<<<<<<.........)))...>>>>>>>.>>......>>....<<<<<<......<<<<...<..<<<<<<<<...<<<......>>>......>>>>>>>>..>........<<....>>...>>>>.....>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<..]]>>...>>.....>>>.>...<<<......<<<......>>>....>>>...)))..<<<<<.<<<<<<<..<<..<<<<...<<<.<<<<<<......<<........>>..........<<.<<......<<..<<.......<<.<<<........>>>.>>.....>>..>>...<..<<<..<<.<<<<<.....<<<.<<<<......>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<.<.<....>>...>>>>>>>..>>>>..>.....<<<<<.....>>>>>........>>>.....>>.>>>.....>>>>>.>.......>>.>>...>>.>>>>.>>>.....<<.<<<................<<<.<<<<....>>>>.>>>..............>>>.>>.............<<<<..........>>>>.............>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<..<....<<<<<<<<.<<<..<<.<<<<...<<<<<.<<<<<<<<<..>>>>>>>>>...>>>>>...>>.>>>>..>>>.>>>>>>>>...>..>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[...[..))))(((.((..((...(.((..((.....(.(.(((..((....(.......................).))................(((.(.(..(.....(((......([...(......((.(((.....))).)).......)......)....((...(((..........)))...))..((....(((........{......................(.....)..)))........)).(]((((..(.....).)))))...)))....)).).)))..(......((....(((((((.........)))))))))........)....(...((.(....).)).......)...((.(..............).))...((....)).....)))).).).....(.(((...((((.....))).))))).)...)).).....(((.((((...(......)....))))..)))....(.(...................)......)..((((([[......((((.....((..]])).......)))).)))))..))..)).)))..[......(.......(.(.((........(....(((.(((....()....))).)))...(.......(...(.)...)....)...((.(((.........((..(.........).((.()))....))........)))...))........(..(.(.((((...........}.....)))).).)....)..).....((..(........(((..((..((((((((...((........))......))))))))..))........(....)....))).......)...)).........)).)....((((((....(...(.((.........)).)...).))))))......{...(((.....(...(.((((((.(((((....))))))))))).)....)...((....))........].))))..).(((......((((....))))....)))...]...](......((((((..((..(((....(((...((((.......(........)............((((.......((..........(..................)........)).......(.......(((..(........(((((....)))..(.((......)))...))........(((...(...(.((..((((((((.((....))..))))))))..)).)..).....((.((.....)).))........))).....)..))).........).........)).))...)).))...))).(...((.((.........(.......(((.((((....)))).))).....).........)).))......(........((..........))........)..)....))).....(.((((...........)))).)......))...))))).).....)..(.(..((....((((........(...(((.(((..((.((((...(((((..((.(.(((..))).).))....)))))...)).))))..)).))))...).......)))).....))...)..)..(...(((((....)))))...)}........ Mammalian pre-termination 80S ribosome with Hybrid P/E- and A/P-site tRNA's bound by Blasticidin S.; 18S Ribosomal RNA 7nwg q3 74 3.8 RF00005 URS0002311A0F_9986 34157102 0030533 9986 gucuccguaguguaggguaucacguucgccuaacacgcgaaagguccucgguucgaaaccgggcggaaacacca ...<<<<..<<<........>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>....... ...((((..((.....[....))..((((.......))))......(.(((..]....)).))))))....... Mammalian pre-termination 80S ribosome with Hybrid P/E- and A/P-site tRNA's bound by Blasticidin S.; A/P-Site tRNA 7nwg v3 18 3.8 34157102 9986 ugcuuaagauuugaaacu .................. .................. Mammalian pre-termination 80S ribosome with Hybrid P/E- and A/P-site tRNA's bound by Blasticidin S.; mRNA 7nwg 33 75 3.8 RF00005 URS000231197C_9986 34157102 0030533 0006412 9986 gcccggauagcucagcguguagagcaucagacuuuuaaucugaggguccaggguucaagucccuguucgggcgcc <<<.<<.....<.........>......<.........>...........<<.......>>....>>.>>.>... (((..(............................................(.........)....)..)).)... Mammalian pre-termination 80S ribosome with Hybrid P/E- and A/P-site tRNA's bound by Blasticidin S.; P/E-Site tRNA 7nwh hh 15 4.1 34157102 9986 ucaaaguuugagcuc ............... ............... Mammalian pre-termination 80S ribosome with eRF1 and eRF3 bound by Blasticidin S.; mRNA 7nwh 5 3543 4.1 RF02540,RF02543 URS0002311970_9986 34157102 0003735 0005840 9986 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggaaauguggcguacggaagacccacuccccggcgccggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcgcgguccggccgugccggcggggcggaucucccgcucccgucggcgggggaccgccccccggccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggccccggcggggaagguggcccgggggccccggguguuacagccccgccccggcagcagcagcucgccgaaucccggggccgagggagcgagacccgugcgccgcgcucuccccccucgggggggccgggccaccccucccacggcgcgaccgcuggggcggacuguccagugcgccccgggcgggucgcgccgucgggcccggggggccacgcgucccccgcgagcgcacggggucggcggcgaugucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcuacgaaagccgccguggcgcaaugaaggugaaggccggcggcgcgccgccggccgaggugggaucccgaggccuuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcgaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccaaaguuucccucaggauagcuggcgcucuccgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcugguguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggaugguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgcuggcagucggcagagcgagaaagagaguggcgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucagccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcuggcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacguuuuuucacugacccggugaggcgggggggcgagccgggcucucgcuucuggcgccaagcgcccggccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauagcgccggagccucgguuggccucggauagccggucccccgccgggguccggugcggagagcccuucgucccgggaaacggggcggccggaaagggggccgcccucucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcugcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<<....<......>.....>>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..[[[...<<<<...<<<<<<<<<<<...>>>>>>>.>>>>.....>>>>...<<<<<<<<<....<<<<<<<<..<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>...>>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<<....<<<<<<<.<<<<<.<<<<<<<.<<<<<<<<<......>>>>>>>>>>>>>>>>>>>>>>>>>...>>>.>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<<<<<<<<<<<<.<<<<...<<..<<<..<<<<<<<......<<<<<<<<.>>>>>>>>.......>>>>>>>..>>>.........>>>>>>...>>>>>>>>>>.....<<.......>>.........<...<<<<<<..>>>>>>....<<<..<<<.<<<<<<<<<<<<<<<<<<<<<<<.<<<<..>>>>.>>>>>>.>>>.>>>>>>>>>>>.>>>...>>>>>.>................>........>>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<.....>>>>.....>>>...<<....>>...<<<<<<<<<<..>>>>>>>>>>..<<<<<...<<<..<<<...(((.[[.>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<<<...<<<....<<<..<.<<<..<<<<.<.........>.>>>>>>>.>..>>>..>>.>...>>>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>>>>>>.>>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<.....................>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<....................]].)))............>>>>>>>>>....>>>>>>.<<<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>.>>.....>>>>>><<<....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<<<<<...>>>>>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<...<<<<<<<....>>>>>>>...<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..{{{..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<..<<...............<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<.>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>..>>>>>>..>>>>>>...>>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{.[[[..<<<<<.<<<<<<<<<.<<<<<<........>>>>>>...<<<<<.....<<<<..<<.<..<..>...>>>..............<<<<<<<<<..>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))]......((((((..(((..>>>>>>.)))))))))..........]]]...}}]]]].......<<..<<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<...<<<<<......>>>>>.....>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]].....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<.....<<<....<<.<<<<<<.}}}..>>>>..>>.>>...>>>....>>>><<<<....<<<<<...........>>>>>....>>>>.>>>...>.>>>>>>.<<<<<<....<<<....<<<........<<<<<..<<<<<.>>>>>.>>>>>.......>>>...<<<..<<<<....<<<<<<<<<........>>>>>>.>>>...>>>>..>>>..............>>>.....>>>>>>.<<<<<.<.............>....<<.<<<<<<<.<<.....<<<<.<..<<<<<.>>>>>..>>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..(((((((((((.....)))))).))))....))))....(((((((((....((((((((..((((((((..({((((......)))))....[[(...).(((....}]])))...).)))))))...))))))))...)))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...(((((((..(((.....((((((((((.(..(((((((.(((((.(((((((.((.(((((.(.....)))))).))))))))))))))))))...))))))))))))))......)))..)).)))))...(((((((((((((((((((((((...((..(((..(((((((.......(((((((.)))))))........)))))))..))).........))))))..))))))))))).....((......{))...........(.(((((.(.))))))....(((..(((.((((((((((((((((.((((((.((((..)))).))))))..)).))))))))))).)))...))))).)............[..).........))).)))))...)))))...)))))))).<((((........))))((((((..(.(((((((((((((..(((..(((((.....))))..)..)))...((....))...((((((((((()))))))))))..(((((...(((..(((]...[[.[.[)))..)))....))))).(((((((((.((((......))))))))))).))....)))))))))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)<)))....((..((.((.......A)))).)).....))))))))).(..(.......)....)..))))))......).))).((((((....(.(((....))).).(.(((((((...(((.((((((((....(((....(((..(..((..((((((.(.....).))))))))..)..)))..)).)....))))))...(((((((((.(......))))))))))....))))))))))))..)...((((.((.((.....)).)).))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.......(((((.(((...................))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((........}.........]..].]].............)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...((....(((....)))..........((.((((.((((...)))).))))))......))....))...(((((........)))))]]((((....(((((...(((((((....)))))))..((((....)))...(...((((((...((((((((((((((((((((((....{{...)))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....(((((((.......))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(........((((....(.[..).....)))).((.((((((((((...))))..)))))).))(...).......(((((((((.>.((.........))...(((((((.....(((.....))).......))))))).].(((.(((..((((((.(..(((.....((((....)))).....))))))))..)))))(((((.........))))).........(..........((((.........))))..).......)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..((((..(.(((((((.(((((((......)))))))...(((((.....((((..(..((.(())..)).)..............(((((.(((..))).)))))..))))..)))))....))))))).)...))))..(((......[)).)(((((...........].)))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(.(((.(((((....{..)))).)))))(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((...(..(((((...((.......))...)))))....)..).)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a.))..))).)))))......(((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}..)))))..)).))...))))...)))).(((....((((.............))))....)))..)))...).)))))..(((((.....(((....(((.........((((...((((.))))..))))........)))...(((..(((.....(((((((((........)))))).)))....)))..)))..............)))......))))).(.(((.(..(.......)..)....((.(((((((.((.....((((.(..(((((.)))))..)))))....))....)))).))).))..))))... Mammalian pre-termination 80S ribosome with eRF1 and eRF3 bound by Blasticidin S.; 28S Ribosomal RNA 7nwh 7 120 4.1 RF00001 URS000002B0D5_9986 34157102 0003735 0005840 9986 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. Mammalian pre-termination 80S ribosome with eRF1 and eRF3 bound by Blasticidin S.; 5S Ribosomal RNA 7nwh 8 151 4.1 RF00002 URS0000D56C3A_9986 34157102 0003735 0005840 9986 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcagguugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<.<<.....>>>.....(.<<<......>>........>>>..)...>>>....<<<..>>><<<<<<<<.......>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]]........)))..)...)))....((....))((((((((.......)))))))).................... Mammalian pre-termination 80S ribosome with eRF1 and eRF3 bound by Blasticidin S.; 5.8S Ribosomal RNA 7nwh 9 1698 4.1 RF01960,RF01959,RF00177 URS00023119A7_9986 34157102 0003735 0005840 9986 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucguacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgcccggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcggccguccccugcucggcgccggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgaccccggucggcguaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggugcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<....<<....<<<...........<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<<<....>>>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<<.>>>>>>>>....>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>..>>>..>...>>.>.....<<<<<<<<<.<<<....>>>..>>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<....<<<.<<<..>>>.>>><<<<<<<.<<..>>>>>>.>>>.<<<<<<.<.......<<...<.......>.<<<<.>>>>...>>......>.>>>..>>>........<.<<.<<<<<<<...............>>>>>>>.>>.>....>>....<<<<<<......<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>.....>>>.>>>...>>>...>>.>...<<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..>.......<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<............................<<<<<......<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<..>>>>.>>>>>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.......>>>>>...>>.>>>>.>>>.....<<.<<<................<<<.<<<<....>>>>.>>>..............>>>.>>............<<<<<..........>>>>>...........>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<<<<<<<<<<<..>>>>>>>>>.>.>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..((....(((.....(([...((.....((.(((.....))).))......))......))..(((...(((((......)))))...))).((..(((((...(......)..)))))......)).(]((((.(((...))))))))...)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).).....(((((((((.((......))..)))))).)))....(.((..(...........)..))......)..((((([[......((((.....((..]])).......)))).)))))..)))))).))).........(.([[...(.(.((...(((..(....(((.(((())).)))).((((((.((())))))).))..((((((.(.......((..((.......)).(((.)))....))......).)))..)))........(.((.(((((((...............))))))).)).)....)....((((.((..(...((((..(((.((((((((...((........))......)))))))).))).......((....))...))))..)..))..)))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.(((((....))))))))))).)..)))...((..]]))...)).....))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((.(..(((.((((((.......(........)...........(((((.(....(((((.....(..((..((........))..))....).)))))....(.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((...(...((((..((.(.(((((((..)))).))).).))..))))..).....(((((.....)))))........)))....))).))).....).))))......).)))))...)).)))).))).(...((.(((........(.......((..((((....))))..))....).........))).))......(.....(((((..........))))).....)..)..).))).....(.(((.((.......)).))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((.((...(((((((((((.(((..))).))))).).)))))...)).)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}........ Mammalian pre-termination 80S ribosome with eRF1 and eRF3 bound by Blasticidin S.; 18S Ribosomal RNA 7nwi 2 76 3.13 RF00005 URS0000868530_9986 34157102 0030533 9986 gucuccguaguguagcgguuaucacguucgccuaacacgcgaaagguccucgguucgaaaccgggcggaaacacca .<.<<<<..<<<..........>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>.>..... .(.((((..(((.....[....))).(((((.......))))).....(((((..]....))))))))).)..... Mammalian pre-termination 80S ribosome with Empty-A site bound by Blasticidin S; P-Site tRNA 7nwi 5 3662 3.13 RF02540,RF02543 URS0002311A23_9986 34157102 0003735 0005840 9986 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcggcccggcggaucuuucccgcgcgggggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucggccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcgcucuccccccucccggcgccgccggggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccgggggaggggccacgcgcgcgucccccgaagagggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcacacgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcgugagccgggcguggaauggagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagcggcgggggcggcgcgcgcgcgcgcccgcccccggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcugggucggucgucggccggcgccuagcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacauguuuuuucacugacccggugaggcgggggggcgagccccgaggggcucucgcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccggucccccgcgggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcacgccguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<<....<......>.....>>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..[[[...<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>....<<<<<<<<....<<<<<<<<.<.<....<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>>.>>>>>>>>>...>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<......>>>..................................<<<<<<<<..<<<......<<<<<<<<.<<<.....<<<<<<<<<<<...<<<....<<<<<.......<<<<.<<<..<<<<..>>>>>>>>>>>..>>.>>>......>>>.>>>>>>>>>>>......>>>.>>>.>>>>>..<<<<<<<..<<<<<<<<<<.<<<........<.<.<<.<<<......<.<<<<..>>>>>........>>>.>>>.>...........>>>...>>>>>>>>>>....................<<<<<..<<<<<<..<<<<<<.>>>>>>>>>>>>....<<<.<<....<<<<<<<<<<<<<<<<.<<<<.....<<....>>.....>>>>.>>>>.>>>>>>>>>>.>>.......>>...>>>........<<<<<<<<.....>>>>>>>>........>>>>>.......>>.>>>>>....>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<......>>>>>>>..<<<<<...<<<..<<<...(((..[[.>>>..>>>....>>>>>.<<<<<<<<..<<.<......>>>..>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<............<<<<<<<<....<<<....<<<....<<<..<<<<.............>>>>>>>....>>>..>>.>....>>>>>>...<<<<<<<<<........>>>>>>>>>...>>...>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<......<..........<<<.<<<<<<<<<<.......<<<...<<....<<.........>>....>>.........<<......>>.....>>>...>>>>>>>>>>>>>..........))).>....>>>>>..>>>...>>>>>>><<<<<<.<<<...........]].))).......................<<<..>>>.......................>>>>>>>>>....>>>>>>.<<<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>.>>.....>>>>>><<<....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<.<<<.....>>>.>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<.....<<.<...<<<<<<<....>>>>>>>...<<<....>>>.......<<<<<<...<<<<<<<<<<<<<<<<<<<<<<<..{{{..>>>>>>.....<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>......<<<<<<<.......>>>>>>>>>>>.>.>>>>>>>>>>>>.........>>>>>>..............>..>>..>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<.<<<<<<<<<<<...<<<<<<.>>>>>>........>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>>.<<<<<.......>>>>>.........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>...>>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<<.<<<<<<<<<<..>>>>>>>>>>...<<<<<.....<<<<..<<.<<<<<<....>>>>>>>>.................<<<<<<<<.....>>>>>>>>.....>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))]......((((((..(((..>>>>>>.)))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]].....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<.}}}..>>>>..>>.>>...>>>>...>>>><<<<....<<<<<...........>>>>>....>>>>.>>>...>.>>>>>>......<<<<<<.....<<<.....<<.........<<<<<..<<<<..>>>>.>>>>>........>>....<<..<<<<....<<<..<<<<<<<......>>>>>>>.>>>...>>>>..>>..............>>>....>>>>>>.<<<<<.<.............>....<<.<<<<<<<.<<.....<<<<.<..<<.<<......>>.>>..>>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..(((((((((((.....)))))).))))....))))....(((((.(((....((((((((.(.(....((((((((..({((((......)))))....[[(...).(((....}]])))...).)))))))).)))))))))...))).)))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((......((((((((.(((.....(((((((((((...(((.(..(((((.((....((((.(((..((((()))))))))))))))).)))..)...))).))))))))))).....).)).))).)))))..((((((((.((((((((((.(((....(...(((.((.(((......(.((((())))))........))).))))).........).)))...))))))))))....................(((((..(((((((..(((((.))))))))))))...(..(.((((..((((((((((((((((((((....((.(....).))....))))))).))))))))))).))....).)))...).)........((((((((.....))))))))........)))))......))).)))))....)))...)))))))).[((((........))))((((((....(((((((((((((..(((..(((((........)))).)...)))...((....))...((((((((....))))))))..(((((...(((..(((...[[[..[..)))..)))....))))).(((((((.(.((.(......))))..))))).))....)))))))))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))....))))))))).(..(.......)....)..))))))......).))..((((((....(.(((....))).)((.(((((((............(.((((((....(((....(((..(.(((..((((.(.(.....)..)))))))).)..)))..)).)....))))))...(((((((((........)))))))))....)...)))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.....{.((..(.(((....(.........)....))).....(...(........).)..).))...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((............].]]].......................(((..))).......................)))))))))....)))))).((((((((((.((......((((.((((....))))))))...)))))))))).)).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...((..(.(((....))).....)....((.((((...((...))...))))))......))....))...(((((........)))))]]((((.....((.(....(.((((....)))).)....(((....)))...(...((((((...(((((((((((((((((((((((...{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)..........)..))..)))).)))..)).....((......)).)))).(((.......)))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((...(((.((.)).)).).......)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(...((.....((((....)))).....)).)))))..))))).((((.........)))).........((.(......).(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.(((((((((.((((((((((..))))))))))...(((((.....((((..(..((((((....)))))).)................(((((((((.....)))))))))....))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((.(.(..(((((...((.......))...)))))....)).).)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a.))..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}..)))))..)).))...))))...)))).(((....((((.....}.......))))....)))..)))...).))))))......(((((......(((.....((..........((((..((((())))).)))).........))....((..((((....(((..((..(((......)))..)).)))...))))..))..............))).....))))).(((((.(..(.......)..)....((.(((((((.((.....((((.(..((.((......)).))..)))))....))....)))).))).))..))))).. Mammalian pre-termination 80S ribosome with Empty-A site bound by Blasticidin S; 28S ribosomal RNA+BlaS 7nwi 7 120 3.13 RF00001 URS000002B0D5_9986 34157102 0003735 0005840 9986 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. Mammalian pre-termination 80S ribosome with Empty-A site bound by Blasticidin S; 5S ribosomal RNA 7nwi 8 156 3.13 RF00002 URS00004B2C76_9986 34157102 0003735 0005840 9986 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<.<<.....>>>.....(.<<<......>>.............>>>..)...>>>....<<<..>>><<<<<<<<.......>>>>>>>>.................... .........................................((((((.[[....[)))...].(.(((......]].............)))..)...)))....((....))((((((((.......)))))))).................... Mammalian pre-termination 80S ribosome with Empty-A site bound by Blasticidin S; 5.8S ribosomal RNA 7nwi 9 1719 3.13 RF01960,RF01959,RF00177 URS0002311A10_9986 34157102 0003735 0005840 9986 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgccacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgccccccguggcggcgacgaccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcgggcguccccgccgccucucggccggggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggugcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauu ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<...<<<..........>>>..>>.>>......<<..<.....<<<.<....<<....<<<<.......<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<<<....>>>>>>...>>>><...<<<<<...<......>..>>>>>........>..<<<<...<<......>>..>>>>..>>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>>>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....<<.<<<<<<.<<<....>>>..>>>>>>..>>......<<..<...........>..>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<.....<<...<<....>>...>>.....<<<........>.>>.....<<<<<<.<.......<<...<.......>.<<<<.......>>>>...>>......>.>>>..>>>.......<<.<..<<<<<<................>.>>>>>.>.>>....>>....<<<<<<......<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>.>.>>.......<<....>>...>>>>.....>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<....<<<<<<.<<<........>>>>>>>>>....>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<......<<.<<........<<.<<<........>>>>>.......>>.>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<....<<<....<<<...<<<....>>>..>>>....>>>....>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.......>>>>>...>>.>>>>.>>>.....<<.<<<................<<<.<<<<....>>>>.>>>..............>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<.<<<<<<<<<..>>>>>>>>>...>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>........ ...((((..[.[[[..))))(((.(((.((...(.((..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..((....((((.......((.....((.(((.....))).))......)).........((((...(((((......)))))...))))....(((((...(......)..)))))...........((((...((......))..))))..))))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).).....((.((((((.(((....)))..))))))..))......((..(...........)..)).........((((([[......((((.....((..]])).......)))).)))))..)).))).)))..[......(.([[...(.(.((...(((..(.....((.(.((....)).).))(.(....(........)....))..((((((.(.......((..((.......)).(((.......)))....))......).)))..))).......((.(..(.((.(.................).)).).).))....)....(((..(...(...((((..((..((((((((...((........))......))))))))..)).......((....))...))))..)...)...))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.((..........)))))))).)..)))...((..]]))...))...].))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((............((........))..........)))))...((.(((...(.((((((....(((.((.((....))...(.((......)))...)).)))....(((...(...(((....((.....(((...(((....)))..))).....))....)))..)..(..(((((.....)))))....)...)))....))).))).....).))))).....).)))))...)).)))).))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....((((............)))).....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..((((.((...(((((((((((((.(...)))))))).).)))))...)).))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}....... Mammalian pre-termination 80S ribosome with Empty-A site bound by Blasticidin S; 18S ribosomal RNA 7nwi K 10 3.13 34157102 9986 aaaguuuagg .......... .......... Mammalian pre-termination 80S ribosome with Empty-A site bound by Blasticidin S; mRNA 7nwt 1 2903 2.66 RF02540,RF02541 URS0000B21DEA_562 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaacccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<<.....>>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<<.<<....>>..>>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<..<<<<...........<<<<<..<<.......<<<<<<<<....>>>>>>>>....>>............>>>>>..>>>>..>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. 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Initiated 70S ribosome in complex with 2A protein from encephalomyocarditis virus (EMCV); 23S ribosomal RNA 7nwt 2 1534 2.66 RF00177,RF01959,RF01960 URS000081169C_562 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.....<<<<<<<<<......>>>>>>.>>>....>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<.....<<<<....>>>>................>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<..<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>.........>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((......((.((((........))))..)).....)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((((.......)))))))).....)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((.(((....))).))).............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Initiated 70S ribosome in complex with 2A protein from encephalomyocarditis virus (EMCV); 16S ribosomal RNA 7nwt 3 120 2.66 RF00001 URS0000049E57_562 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Initiated 70S ribosome in complex with 2A protein from encephalomyocarditis virus (EMCV); 5S ribosomal RNA 7nwt 5 76 2.66 RF00005 URS00023119AC_562 0030533 0006412 562 gcggggungagcagccuggnagcucgucgggnucauaacccgaagaucgucggnucaaauccggcccccgcaaccn <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Initiated 70S ribosome in complex with 2A protein from encephalomyocarditis virus (EMCV); fMet-NH-tRNA(fMet) 7nww 1 2903 3.05 RF02540,RF02541 URS00021ED9BC_562 34994471 0003735 0005840 562 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<<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<<..<<<.........>>>..>>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<<.<<....>>..>>>>>>..>....>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<.<<.<<<...............<....<.......<<<<.<<<....>>>.>>>>....>..............>......>>>.>>.>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((.(.(.....).).).))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..((...........))..)))........(((......)))..)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((..((....))..)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((.(.(.((((.(.............(..(((........(...(......)...).....)))............)....).)))).)..))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(.(((((....))).)).)....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). CspA-27 cotranslational folding intermediate 1; 23S rRNA 7nww 2 1534 3.05 RF00177,RF01959,RF01960 URS000081169C_562 34994471 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<......>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<<....>>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<....>>>>>>..............>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((........))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((((.......)))))))).....)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((..((....))..))).............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... CspA-27 cotranslational folding intermediate 1; 16S rRNA 7nww 3 120 3.05 RF00001 URS0000049E57_562 34994471 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). CspA-27 cotranslational folding intermediate 1; 5S rRNA 7nww z 88 3.05 RF00005 URS0001DD2ACB_562 34994471 0030533 0006412 562 ggugagguguccgagungcugaaggagcacgccuggaaaguguguauacggcaacguaucgggggnucguaucccccccucaccgcca <<<<<<<..<<<...........>>><<<<<<.......>>>>>><<<<<....>>>>>.<<<<<.......>>>>>>>>>>>>.... (((((((..(((.....[.....)))(((((.........))))).((((....))))..(((((..]....)))))))))))).... CspA-27 cotranslational folding intermediate 1; tRNA-Ser 7o19 AA 1534 2.9 RF00177,RF01959,RF01960 URS000081169C_83333 34504068 0003735 0005840 83333 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<<....>>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<<..>>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>..<<.<<<<<......<<<.<<<<<<.......>>>>>>>>.>........>>>>>....>>.<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<....<..<<....>>.>......<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((((((((..)))))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((.(...(...((.((((((.......)))))))).....)....).)))....)).(((.([[[...(((((.....((.]]])).......)))))).)))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((....(..((....)).)......((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Cryo-EM structure of an Escherichia coli TnaC-ribosome complex stalled in response to L-tryptophan; Ribosomal RNA 16S 7o19 BA 2897 2.9 RF02540,RF02541 URS0000A7632D_83333 34504068 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<.....>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<<..<<<<.......>>>>..>>>.........<<......>>...>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<......>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<<.<<....>>..>>>>>>..>....>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<.<<.<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>.>>.>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((((.....)).))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(...((......)).).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((((......))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((.(((.((.(.(..........((((..(((......((((((((....))))))))...)))............)))).).).)).))).)))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).).....((.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..))....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Cryo-EM structure of an Escherichia coli TnaC-ribosome complex stalled in response to L-tryptophan; Ribosomal RNA 23S 7o19 BB 120 2.9 RF00001 URS0000049E57_83333 34504068 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Cryo-EM structure of an Escherichia coli TnaC-ribosome complex stalled in response to L-tryptophan; Ribosomal RNA 5S 7o19 B8 77 2.9 RF00005 URS00001DEEBE_83333 34504068 0030533 0006412 83333 cggugauuggcgcagccugguagcgcacuucguucgggacgaaggggucggagguucgaauccucuaucaccgacca <<<<<<<..<<<<.........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))).... Cryo-EM structure of an Escherichia coli TnaC-ribosome complex stalled in response to L-tryptophan; P-site tRNA-Pro 7o1a AA 1534 2.4 RF00177,RF01959,RF01960 URS000081169C_83333 34504068 0003735 0005840 83333 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<<<..>>>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<<..>>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>..<<.<<<<<......<<<.<<<<<<.......>>>>>>>>.>........>>>>>....>>.<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<.....<<<<....>>>>......<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((((((((..)))))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((...(....).)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((.(...(...((.((((((.......)))))))).....)....).)))....)).(((.([[[...(((((.....((.]]])).......)))))).)))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((....((.((....)).))......(....)...))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Cryo-EM structure of an Escherichia coli TnaC(R23F)-ribosome complex stalled in response to L-tryptophan; Ribosomal RNA 16S 7o1a BA 2897 2.4 RF02540,RF02541 URS0000A7632D_83333 34504068 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<<..>>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<....<.<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>..>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<.....>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<<..<<<<.......>>>>..>>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<......>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<<.<<....>>..>>>>>>..>....>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((((.....)).))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(...((......)).).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((((......))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((((.((((.((((.(..........(.((..(((......((((((((....))))))))...)))............)).).).)))).)))).))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).).....((.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..))....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Cryo-EM structure of an Escherichia coli TnaC(R23F)-ribosome complex stalled in response to L-tryptophan; Ribosomal RNA 23S 7o1a BB 120 2.4 RF00001 URS0000049E57_83333 34504068 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Cryo-EM structure of an Escherichia coli TnaC(R23F)-ribosome complex stalled in response to L-tryptophan; Ribosomal RNA 5S 7o1a B8 77 2.4 RF00005 URS00001DEEBE_83333 34504068 0030533 0006412 83333 cggugauuggcgcagccugguagcgcacuucguucggnacgaagggnucggagguucgaauccucuaucaccgacca <<<<<<<..<<<<.........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))).... Cryo-EM structure of an Escherichia coli TnaC(R23F)-ribosome complex stalled in response to L-tryptophan; P-site tRNA-Pro 7o1c AA 1534 2.6 RF00177,RF01959,RF01960 URS000081169C_83333 34504068 0003735 0005840 83333 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<.<....>.>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<<..>>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>..<<.<<<<<......<<<...<<.<<....>>.>>...>>.>........>>>>>....>>.<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<....<<<<<....>>>>>.....<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((((((((..)))))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((.(...(...((...((.(.......)))...)).....)....).)))....)).(((.([[[...(((((.....((.]]])).......)))))).)))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((....(((((....))))).....((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Cryo-EM structure of an Escherichia coli TnaC(R23F)-ribosome-RF2 complex stalled in response to L-tryptophan; Ribosomal RNA 16S 7o1c BA 2897 2.6 RF02540,RF02541 URS0000A7632D_83333 34504068 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<.....>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<......>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<..<<<.......<<<<<<<....>>>>>>>....>>>............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))..(((((((..((((((((((.....(((...(((.((((...((((.....)).))...)))).)))..)).).....)))))).)))..)))))))).....(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..((((.......))))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((((......))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((...(.((...(..........((((...((......((...(((....)))...))...)).............)))).)...)).)...)))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).).....((.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..))....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Cryo-EM structure of an Escherichia coli TnaC(R23F)-ribosome-RF2 complex stalled in response to L-tryptophan; Ribosomal RNA 23S 7o1c BB 120 2.6 RF00001 URS0000049E57_83333 34504068 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Cryo-EM structure of an Escherichia coli TnaC(R23F)-ribosome-RF2 complex stalled in response to L-tryptophan; Ribosomal RNA 5S 7o1c B7 10 2.6 34504068 83333 cgcccgugau .......... .......... Cryo-EM structure of an Escherichia coli TnaC(R23F)-ribosome-RF2 complex stalled in response to L-tryptophan; mRNA 7o1c B8 77 2.6 RF00005 URS00001DEEBE_83333 34504068 0030533 0006412 83333 cggugauuggcgcagccugguagcgcacuucguucgggacgaaggggucggagguucgaauccucuaucaccgacca <<<<<<<..<<<<.........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))).... Cryo-EM structure of an Escherichia coli TnaC(R23F)-ribosome-RF2 complex stalled in response to L-tryptophan; P-site tRNA-Pro 7o5b U 77 3.33 RF00005 URS00002C7A07_224308 35217658 0030533 0006412 224308 gguccgguaguucaguugguuagaaugccugccugucacgcaggaggucgcggguucgagucccguccggaccgcca <<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.........)))).(((((.......)))))......(((.........))).))))))).... Cryo-EM structure of a Bacillus subtilis MifM-stalled ribosome-nascent chain complex with (p)ppGpp-SRP bound; tRNA 7o5b W 266 3.33 RF01854 URS000086853B_224308 35217658 0006617 0048501 224308 gccgugcuaagcggggagguagcggugcccuguaccugcaauccgcucuagcagggccgaaucccuucucgagguucguuuacuuuaaggccugccuuaaguaagugguguugacguuuggguccugcgcaaugggaauucaugaaccaugucagguccggaaggaagcagcauuaagugaaaccucucaugugccgcaggguugccugggccgagcuaacugcuuaaguaacgcuaggguagcgaaucgacagaaggugcacggu ..<<<<<...<<.<<<......(((..>>>....<<<<<...))).....>>>>>>>......<<<...............<<<<.......<<......<<....<<<.......<.......<<<<<<<.<<<<..<<<<<.............<<<....>>>...........>>>.>>...>>>>..>>.>>>>>..........>....>>>....>>.....>>......>>>>..............>>>.>>>>>.. .((((((...((.(((......[[...)))....(((((....]].....)))))))......(((....(.(........((((....(.((.(..(..(...((((....(..(.....(.((((((((.((.(..(((((.....(........((....)).........)..))).))...).))..)).))))).)....)....))...))).)..)..).).)..))..)))).......)..)...))).)))))). Cryo-EM structure of a Bacillus subtilis MifM-stalled ribosome-nascent chain complex with (p)ppGpp-SRP bound; SRP RNA (266-MER) 7o5b X 2887 3.33 RF02540,RF02541,RF00002 URS00023119D6_224308 35217658 0003735 0005840 224308 guuaaguuagaaagggcgcacgguggaugccuuggcacuaggagccgaugaaggacgggacgaacaccgauaugcuucggggagcuguaagcaagcuuugauccggagauuuccgaauggggaaacccaccacucguaauggagugguauccauaucugaauucauaggauaugagaaggcagacccggggaacugaaacaucuaaguacccggaggaagagaaagcaaaugcgauucccugaguagcggcgagcgaaacgggaucagcccaaaccaagaggcuugccucuugggguuguaggacacucgaacgagguagaugaagaggucuggaaaggcccgccauaggagguaacagcccuguagucaaaacuucguucgaguggauccugaguacggcggaacacgugaaauuccgucggaauccgggaggaccaucucccaaggcuaaauacucccuagugaccgauagugaaccaguaccgugagggaaaggugaaaagcaccccggaaggggagugaaagagauccugaaaccgugugccuacaaguagucagagcccguuaacgggugauggcgugccuuuuguagaaugaaccggcgaguuacgaucucgugcaagguuaagcagaagaugcggagccgcagcgaaagcgagucugaauagggcgcaugaguacguggucguagacccgaaaccaggugaucuacccauguccagggugaaguucagguaacacugaauggaggcccgaacccacgcacguugaaaagugcggggaugagguguggguaggggugaaaugccaaucgaaccuggagauagcugguucucuccgaaauagcuuuagggcuagccucaagguaagagucuuggagguagagcacugauuggacuaggggccccuaccggguuaccgaauucagucaaacuccgaaugccaaugacuuauccuugggagucagacugcgagugauaagauccguagucgaaagggaaacagcccagaccgccagcuaaggucccaaaguauacguuaaguggaaaaggauguggaguugcuuagacaaccaggauguuggcuuagaagcagccaccauuuaaagagugcguaauagcucacuggucgagugacucugcgccgaaaauguaccggggcuaaacguaucaccgaagcugcggacuguucgaacagugguaggagagcguucuaagggcugugaagccagaccggaaggacugguggagcgcuuagaagugagaaugccgguaugaguagcgaaagaggggugagaauccccuccaccgaaugccuaagguuuccugaggaaggcucguccgcucaggguuagucgggaccuaagccgaggccgaaaggcguaggcgauggacaacagguugauauuccuguaccaccuccucaccauuugagcaauggggggacgcaggaggauaggguaagcgcgguauuggauauccgcguccaagcaguuaggcugggaaauaggcaaauccguuucccaaaggcugagcugugauggcgagcgcgaaguuccugauuccacacugccaagaaaagccucuagcgaggugagaggugcccguaccgcaaaccgacacagguaggcgaggagagaauccuaaggugaucgagagaacucucguuaaggaacucggcaaaaugaccccguaacuucgggagaaggggugcucuguuagggugcaagcccgagagagccgcagugaauaggcccaggcgacuguuuagcaaaaacacaggucucugcgaagccguaaggcgaaguauaggggcugacgccugcccggugcuggaagguuaagaggagcgcuuagcguaagcgaaggugcgaauugaagccccaguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgacccgcacgaaaggcgcaacgaucugggcacugucucaacgagagacucggugaaauuauaguaccugugaagaugcagguuacccgcgacaggacggaaagaccccguggagcuuuacugcagccugauauugaauguugguacagcuuguacaggauagguaggagccuuggaaaccggagcgccagcuucgguggaggcaucggugggauacuacccuggcuguauugaccuucuaacccgccgcccuuaucgggcggggagacagugucaggugggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguucccucagaaugguuggaaaucauucgcagaguguaaaggcacaagggagcuugacugcgagaccuacaagucgagcagggacgaaagucgggcuuagugauccggugguuccgcauggaagggccaucgcucaacggauaaaagcuaccccggggauaacaggcuuaucucccccaagaguccacaucgacggggagguuuggcaccucgaugucggcucaucgcauccuggggcuguagucggucccaaggguugggcuguucgcccauuaaagcgguacgcgagcuggguucagaacgucgugagacaguucggucccuauccgucgcgggcgcaggaaauuugagaggagcuguccuuaguacgagaggaccgggauggacgcaccgcugguguaccaguuguucugccaagggcaucgcuggguagcuaugugcggacgggauaagugcugaaagcaucuaagcaugaagccccccucaagaugagauuucccauuccgcaaggaaguaagaucccugaaagaugaucagguugauaggucugagguggaaguguggcgacacauggagcugacagauacuaaucgaucgaggacuuaacc <<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<.....((.>>>.....<<<<<<<..<<<)).....>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<<<<<<<<.........>>>>>>>.>>.>>....<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<......<<.....>>.....>>>>...(((....<<<<<.<<....>>.>>>>>......<<<<<<...<.<<<<<<<.<<<.....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>....>>..>>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<......>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<.<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>......>>>>>.>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<...<<<<<<<<<.....<<<...<<<<<<<<...<<..<<<.....>>>...>>...>>>>>>>>..>>.>.....>>>>.>>>>>..>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<.....<.........>.....>>......................>>>>>....>>>>>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<..>>>>>>....>>>>>><.<<<<<<..<<......<<<<<.<<....>>.>>>>>...>>..>>>>>>..>.....>>>>>><......<<....<<<<<<.......>>>>>><<<<....<<<<<.<<<..<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<.<<<<<<......<<...<<<<....<<<<..<<<..<<<.<<<<<<<<...(((....>>>>>><<..<<<<<..<<<<<<<<<<<.<<.....>>>>>>>>>...>>>>..>>>>>...>><..<..>...>>>>>>...>>>...>>>>.........>>>>..>>..>>>>>>>>>>>>>>>.>>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<<..............<<<<<.....<..>......>>>>><<<<<....<<<<....>>>>...>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>..<<<<.<<<..<<<<<<<..<<<<..<<...<<<<<<.<<....>>..>>>>>>...>>..>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>...>>.>>>>>>>....>>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<<.<<<.<<....<<.......................<<........<<..<<....>>..>>.....>>........................>>...>.>.>>>....<<.<<<<<<.....>>>>>>>>.....>>>>>>>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.)))>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>>. (..(.((......((((((((((.....(((..(((((((((((((......((((((..[..[[[)))...].((((((...(((]]..]..)))......))))))...)))....(((....)))(((((((......))))))).(((((((((.........))))))).)).))....((((((.....(...[..)......))))).).........((....))...((((......((.]...)).....))))...((((...(((((.((....)).)))))....{.(((((.......((((((.(((...(.((((......)))))[[(...).(((.....]])))...)))...)))))).......)..)))))....((((((((..[......))))))))....}.(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((..((((..[...))))..)))).<.(.(........).).((((((....(((((((.(((((..(((...(((.....)))...)))...((....))..((((.....))))......))))).)))))))..((.(...((((((.....(((((((((..((((...((((((......))))))...)<)))...(((.(((((.......A))))))))....))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((...(((((((((.....(((...((((((((...((..((.(....)))...))...))))))))..)).).....)))).)))))..))))))).))..(((((((.((......)).)))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((.(.....{.(((((.(((....(.........)....)))..........(......)....)))))...).)))))))).))...........]]].)...))))))))))...)))))))((((((..))))))....))))))(((((((....(......(((((.((....))])))))...)....))))).)).....))))))(......((....((((((.......))))))((((....(((...((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((.((((((......((...((((....((((..(((..(((.(((((((((...{{..).))))))((..(((((..(((.(((((((.((.....)))))))))....)))..)))))...))(..(())...))))))...)))...))))(..).....))))..))..))))))))))))))).))).....((......))..))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.[..).....)))))(((((....((((....))))...)))))(...).......(((((((((.>.((.........))...(((((((.....(((....))).......))))))).]((((.(((..(((((((..(((...((...(((((..((....))...)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).[..(((((.....>].)))))..((((((((.(((.((......((((.((((((..(((((.(((((((((.((..(....((((..............(.......((.......(((..((....))..)))....)).................).....)))).....).))....((.((((((.....)))))))).....)))))))))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....((((((..((..]]]]..)).)))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..a.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..((((....))))....(((.(((((.......)))))....(..(((((.(((....(((((....)))))...)))..)))))...)....)))....)))...). Cryo-EM structure of a Bacillus subtilis MifM-stalled ribosome-nascent chain complex with (p)ppGpp-SRP bound; 23S rRNA (2887-MER) 7o5b Y 112 3.33 RF00001 URS0000BC467F_224308 35217658 0003735 0005840 224308 ugguggcgauagcgaagaggucacacccguucccauaccgaacacggaaguuaagcucuucagcgccgaugguagucggggguuucccccugugagaguaggacgccgccaa <<<<<<<....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<.......<<.<<<<<...>>>>>.>>.......>>..>>>>>>>. (((((((....((((((((.....((((((...(.....)...))))..))....)))))).)).((.......((.(((((...))))).)).......))..))))))). Cryo-EM structure of a Bacillus subtilis MifM-stalled ribosome-nascent chain complex with (p)ppGpp-SRP bound; 5S rRNA (112-MER) 7o5b A 1533 3.33 RF00177,RF01959,RF01960 URS000197CF6E_224308 35217658 0003735 0005840 224308 ggagaguuugauccuggcucaggacgaacgcuggcggcgugccuaauacaugcaagucgagcggacagaugggagcuugcucccugauguuagcggcggacgggugaguaacacguggguaaccugccuguaagacugggauaacuccgggaaaccggggcuaauaccggaugguuguuugaaccgcaugguucaaacauaaaagguggcuucggcuaccacuuacagauggacccgcggcgcauuagcuaguuggugagguaacggcucaccaaggcgacgaugcguagccgaccugagagggugaucggccacacugggacugagacacggcccagacuccuacgggaggcagcaguagggaaucuuccgcaauggacgaaagucugacggagcaacgccgcgugagugaugaagguuuucggaucguaaagcucuguuguuagggaagaacaagugccguucgaauagggcgguaccuugacgguaccuaaccagaaagccacggcuaacuacgugccagcagccgcgguaauacguagguggcaagcguuguccggaauuauugggcguaaagggcucgcaggcgguuucuuaagucugaugugaaagcccccggcucaaccggggagggucauuggaaacuggggaacuugagugcagaagaggagaguggaauuccacguguagcggugaaaugcguagagauguggaggaacaccaguggcgaaggcgacucucuggucuguaacugacgcugaggagcgaaagcguggggagcgaacaggauuagauacccugguaguccacgccguaaacgaugagugcuaaguguuaggggguuuccgccccuuagugcugcagcuaacgcauuaagcacuccgccuggggaguacggucgcaagacugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggucuugacauccucugacaauccuagagauaggacguccccuucgggggcagagugacagguggugcaugguugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuugaucuuaguugccagcauucaguugggcacucuaaggugacugccggugacaaaccggaggaagguggggaugacgucaaaucaucaugccccuuaugaccugggcuacacacgugcuacaauggacagaacaaagggcagcgaaaccgcgagguuaagccaaucccacaaaucuguucucaguucggaucgcagucugcaacucgacugcgugaagcuggaaucgcuaguaaucgcggaucagcaugccgcggugaauacguucccgggccuuguacacaccgcccgucacaccacgagaguuuguaacacccgaagucggugagguaaccuuuuaggagccagccgccgaaggugggacagaugauuggggugaagucguaacaagguagccguaucggaaggugcggcugg ...<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<..<<.....<<..<..>.>.>.....>>..>>>>>......<<........<<<<<<<..<<...<<<<<<<.<<<<.....<<<<<<....>>>>>>......>>>>.....<<<<<<<<<<....>>>>>>>>>>.....<<<<<<....>>>>>>.>>>>>>>..>>>>>>>>>.<<<....<<<..<.<<<<<<.......>>>>>>>.>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.......<.<<<....<<<<....>>>>..>>>>.>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<<............<<<<<<.....>>>>>>.............>>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<.......<<<<<<.....>>>>>>.....>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<......>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<....<<<<<....>>>>>....<<<....>>>.>>>>>.>>.<<<.<<<...<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<...<<......>>.>>...>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>.>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<..<<<<....<....<..<<...<<<...>>>..>>>.....>...>>>>..>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.. ...((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((...(....(((.((..)).)))....)...)))))......(((.......(((((((..((...((((.((.((((.....((((((....))))))......)))).....(((((((.((....)).))))))).....(((.((....)).))).)).))))..))))))))).(((....(((..(.((((((.......)))))).))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....((((((...(.....(..((((((.....))))))..).....)....))))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(.(((((.(((((((((.......((((((.....)))))).....)))))))..))))))).)..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((......))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..(((((((((.(.....((........))..........(((((((..(...(((((((....(((((....)))))....(((....))).))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....(((..(.(((.(...((..((......))))....).))).)..(..(((((.....))))).....)...))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((..((((....(.((.(..((...(((...)))..)).).)).)...))))..))))))..))).))))..).))...)..)..(((((((((....)))))))))}. Cryo-EM structure of a Bacillus subtilis MifM-stalled ribosome-nascent chain complex with (p)ppGpp-SRP bound; 16S rRNA (1533-MER) 7o7y A2 1770 2.2 RF01960,RF01959,RF00177 URS00023119C9_9986 34029205 0003735 0005840 9986 uaccugguugauccugccaguagcaunugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucnuuaaaucaguuauggunccuunggucgcucguacuuggauaacugugguanuucuagngcuaananaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucagaucaaaaccaacccggugccggcggcuuuggugacucuagauaaccucgggccgaucgcacgcccuccguggcggcgacgacccauucgaacgucngcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgaunccggaganggagccugagaaacggcuaccacauncaaggnaggcagcaggcgcgcnaauuacccacucccgacccggggangungugangaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaanuccuuuaacgaggnuccauuggagngcaagucuggugccagcagccgcggnaauuccagcuccaauancguauauuaaaguugcugcaguunaaaagcucguaguungaucuugggagcgggcggccgcccguccccgccucucggcgccccggggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaaungaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagancgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacncaacacgggaaaccucacccggcccggacacggacagganugacagauugauagcucuuucucgauuccguggguggngnugcauggcnguucuuaguugguggagcgauuugucugguuaauuccgauaacgancgagacunuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuncuuanagggacaaguggcguucagccacccgagauugagcaauaacangucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgagnaauucccaguaagugcgggucauaagcuugcguugauunagucccugcccuuuguacacaccgnccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggucggcccacggcccuggcggagcgcugagaagacggucgaacungacuaucuagaggaaguaaaagucguancaagguuucnguaggugnnccugcggaaggaucauua ...<<<<<...[[[[>>>>>[[[.((((((.....{{.........[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[......{{....[[[[[.........<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<<<....>>>>>>...>>>>[[..(((((.....<<<<<<<<<<<<<..>>>>.......<......>..)))))......]]...<<<<.<<<<......>>>>>>>>.]].]]]...}}....]]].<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<<...>>>>..>>>......}}.......<<<<<<<<<.<<<....>>>..>>>>>>.>>>......<<..<...........>..>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..)))))).]]]............{{.......{{...[[[.[[....<<<.<<<<<<<..>>>>>>>.>>><<...<<<..<<<<<>>>>>.>>>.>>..<<<<<<.<.......<<...<.......>.<<<<.......>>>>...>>......>.>>>..>>>........{.[[.(((((((.....>>>>>>>>>.))))))).]].}....]]....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<<....>>>>>>>>>>>.>..>>>...<<..}}>>...>>.....>>>.....<<<......<<<......>>>....>>>..]]]]..<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<........<<........>>..........<<<<<......<<<<<<.......<<.<<<........>>>.>>.....>>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<.......>>>>.>>>>.....>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>>......>>>>>......>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<<<<<<<<<<<<<<.....>>>>>>>>>>>>.>.>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))((...(((((......(..((.....(((.(((..((....((....((..........))...)){))......(((.......(((.(.(..((....(((.....(({...((.....((.(((.....))).))......))......)).((((...(((((......)))))...))))((..(((((.....[[.[[[[[[.(((())))........(......)..)))))......)).(}((((.((((......)))))))))...)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)...)........(((((((((.(((....)))..)))))).)))....(.((..(...........)..))......)..((((([[....(.(.((.....((..]])).......)).)))))))..)))))...))..{......(.({{...(.(.((...(.(..(....(((.(((((((()))))))).)))((.....((.((((()))))))...))..(..(((.(........(..((.......)).((((...)..)))....).......).)))....)........(.((.(((((((.....]]]]]].]].))))))).)).)....)....(((.((...(...(((...((..((((((((...(..........)......))))))))..)).......((....))....)))..)...))..))..)).)...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..(.((((((.(((((....))))))))))).)..)))...((..}}))...))...}.))))).).(((......((.(....).))....)))...]]].]((((..(((((((..((..((.((..(((..(((((.......(........)...........(((((.(....(((((.....(..(..(((........)))..)....).)))))...((.(((...(.((((((.(..((..(((((....)))..(.((......)))...))..))....(((...(...((.(..(((((((((((((....).)))).)))).....))))..).))..).....(((((.....)))))........))).)..))).))).....).))))).....).)))))...)).)))..))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....((((............)))).....)..)..)).)).....((((((((.......))))))))......))...))))))).)).))..(.(..((.(..((((.((..(.((((((((.(((..((((.((...((((((.((.((((((((.....)))))))).))..).)))))...)).))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>........ Rabbit 80S ribosome stalled close to the mutated SARS-CoV-2 slippery site by a pseudoknot (high resolution); 18S rRNA 7o7y AI 76 2.2 34029205 9913 nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnncca ............................................................................ ............................................................................ Rabbit 80S ribosome stalled close to the mutated SARS-CoV-2 slippery site by a pseudoknot (high resolution); E-site tRNA 7o7y AT 76 2.2 RF00005 URS00001CE4E0_9913 34029205 0030533 0006412 9913 gccgaaauancucngnngggagagcnuuaganunaanaucuaaagnucncuggnucgnucccggguuucggcacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..))))...((.........)).......(((((..]....)))))))))))).... Rabbit 80S ribosome stalled close to the mutated SARS-CoV-2 slippery site by a pseudoknot (high resolution); P-site Phe-tRNA(Phe) 7o7y B5 3764 2.2 RF02543,RF02540 URS000231197F_9986 34029205 0003735 0005840 9986 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcgguggggcgcgggaaauguggcguacggaagacccacuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagngngaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcgugguccggccgugccggcggucucggcggaucuuucccgcuccccguuccuggggguggggucggcgggggaccgccccccggccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggccccggcggggaagguggcccggggggacgccucgccgccgucguccgcggcggcggcgggcgcgaccccuccccggguguuacagccccgccccggcagcagcagcucgccgaaucccggggccgagggagcgagaccugugucgccgcgcucuccccccucgggggggccgggccgccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgugucacgccgucgggcucgggggaggccacggcgcgucgcgcgccggcgcgcgcgcgcgagcgagcgcacggggucggcggcgaugucggcuacccacccgacccnucuugnaacncggaccaaggagunuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcggcggcgccgucgucggccgaggugggaucccgaggcccuuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccnanagauggugancuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauagnggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcaaccccgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcngaacuggcgnugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgcuggcagucggcagagcgagaaagagaguggagccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaunuuggugguagunnnaaauauucaaacgagaacuuugaaggccgaaguggngaaggguuccaugngaacagnanuugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucagccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccnuauccgcagcaggucuncaaggugaacngccucuggnauguuggaacaanguagguaagggaagucggcaagcnggauccguaacuucnggauaaggauuggcucuaagggcugguagcagccgacuuagaacuggugcggaccaggngaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugccnagugcucugaaugucanagugangaaauucaaugaagcgcggnuaaacggcgggaguancuaugacucucuuaagguagcnaanugccucnucaucuaauuagugangcgcaugaanggaugancgagnuucccacugunccuaccuacuauccagcgaaaccacngncaagggaacgggcuuggnggaaucagcggngaaagaagacccuguugagcuugacncuagucuggcacggugaanagacaugagagguguagaauaagugggaggcccgggccgccggugaaauaccacuacucuuaucguuuuuucacugacccggugaggcgggggggcgagccccgaggggcucucgcuucuggcgccaagcgccgggccccgucgguccgggccggcggcggccgggcgcgacccgcuccggggacagugccagguggggaguuugacugnggcgguacaccugucaaacgguancgcaggnnuccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucagnacgaauacagaccgugaaagcggggccucacgauccuucugagcuuuuggguuuuaagcaggangugucagaaaaguuaccacagngauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuungaugucggnucuuccuaucauugugaagcagaauucaccaagcguungaunnuucacccacuaauagggaacgugngcugggnuuagancgucgugagacagguuaguuuuacccuacugaugnuguguuguugccaugguanuccugcucaguacgagaggaaccgcagnuncanacauuugguguaunugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgaaggagccucgguuggccucggauagccggucccccgcgggguccggugcggagagcccuucgucccgggaaauggggcgcggccggaaagggggccgcccucucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..[[[..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>>..<<<<<<<<<....<<<<<<<<.<<<....<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>>>>>>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<<....<<<<<<<.<<<<<.<.....<<<<<.<<<..<<<<<<<<<<<<<<<..>>>>>>>>>..>>>>>>>>>>>>>>.>>>>>>>>>>...>>>.>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<.<<<<<<<<<<<<<<<...<<..<<<..<<<<<<<......<<<<<<<<<<....<<<<<<<<<<<<<<..>>>>>>>>>>>>>>........>>>>>>>>>>.......>>>>>>>..>>>.........>>>>>>..>>>>>>>>>>>.....<<.....[[>>......<<<<<<.<<<<<<<.>>>>>>>.<<<<<<.<<<<.<<<<<<<<<.<<<<<<<<<<<<<<.<<<<....>>>>.>>>>>>>>>>>.>>>.>>>>>>.>>>...>>>>..>>>>.>><<<<<.<<<<<<<..>>>>>>>>>>>>....>>>>>>......>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<<<<...<<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<<<<<<..>>>>>>>>>>>>..<<<<<...<<<..<<....((((.{{..>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>>.<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<..........<<<.<<<<<<<<<...<<<....<<<..<.<<<..<<<<<<.<.....>.>>>>>>>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.........>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<.......]]...........}}.))))..............>>>>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<<<<<...>>>>>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<..<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..{{{..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<....>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<<.<<<<<<<<<<<<<<<<<..........<<<<<..<<<<..>>>>............>>>>>.>>>>>>>.>>>>>>>>>>...<<<<<.....<<<<..<<.<<<<<<<..>>>>>>>>>..............<<<<<.<<<<.<<<<<<<<..>>>>>>>>..>>>>.>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>><<<<....>>>>>>)))]......((((((..(((..>>>>>>.)))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]].....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<}}}.>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.....<<<<<<<..<<..<<<<....<<<........<<<<<..<<<<..>>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<........>>>>>>>>>>...>>>>..>>>..............>>>>..>>>>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<.<..<<<<<......>>>>>..>>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..(((((((((((.....)))))).))))....))))....(((((((((....((((((((.((.....((((((((..({((((......)))))....[[(...).(((....}]])))...).))))))).))))))))))...)))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....((((((((((.(..(((((((.(((((.((....(((((.(((..(((((((.(((((((()))))))).)..)))))))))))))))))))))))))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((..(((((((......((((((((((...((((((((((((((....))))))))))))).)......)))))))))).......)))))))..))).........))))))..))))))))))).....((.....{{))......((((((.(((((((.))))))).((((((.((((.(((((((((.((((((((((((((.((((....)))).))))))))))).))).)))))).)))...))))..)))).))(((((.(((((((()))))))))))))..[.)))))).....))).)))))...)))))...)))))))).<((((........))))((((((....(((((((((((((..(((..((((..........)))..)..)))...((....))...((((((((((((()))))))))))))..(((((...(((..((.(].[[[[.[[[)))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......B)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((..........(((.((((((((.....((.....((.....((..((((((.(.....).)))))))).....))...))......))))))...(((((((((.(......))))))))))....))))))))))))..))..((((..(.((.....)).)..))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.....A.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((.......}}.........].]].]]]].(...)........)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((..(((((((...((.....)).))))))....[[(((.((...(.....(((....)))...(.)....((.(((((((((...))))))))))).......)....))...(((((........)))))]]((((....(((((...((.((((....)))).))..((((....)))...(...((((((...((((((((((((((((((((((....{{...)))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).))).))).....((......)).)))).((((.....))))..)))....(((......((((((..((..(....(.......(((((....(.[..).....)))))((.(((((((((((....)))))..)))))).))(...).......(((((((((.>.(...........)...(((((((....((((.....))))......))))))).].(.(.(((..((((((.(...(......((.(....).))......).)))))..)))))(.(.(.........).).)........((..........(((((.......)))))..)..)....).)....)).))))))).)..)))..))))))...)))))....)).[..((.((.....>].)).))....(((((..(((.((......((((.(((((...(((((.(((((((((.(((((((((((((((((.......[..(((((..((((()))))..........].))))).))))))).))))))))))...(((((.....((((..((.(((((((..)))))))))..............(((((.(((((((((((.(()).))))))).)))).)))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(..((.(..((....{..))...))).)(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}.....)))..)))))).......(....(.((((.(...((.......))...).))))...)....)........((((.((((((..(.(.(.(((......))).)...).).(((.(.....).))).....)))))..)...))).)......((((((....))).)))...b.))..))).))))).....(.((.(.(..(((..(.(((((......(....).....))))).)(((.....((((....((.(((((((}}..)))))..)).))...))))....))).((((...((((.....a.......))))...))))..)))...).).)).).....(((((((..((..((((.(..(((.........((((..((((())))).))))........)))...(((..((((....((((.((((((........))))))))))...))))..)))...........)..))))..)))))))))(((((....(.......).......((.(((((((.((.....(.((.(..(((((......)))))..))).)....))....)))).))).))..))))).. Rabbit 80S ribosome stalled close to the mutated SARS-CoV-2 slippery site by a pseudoknot (high resolution); 28S rRNA 7o7y B7 120 2.2 RF00001 URS000002B0D5_9986 34029205 0003735 0005840 9986 nucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. Rabbit 80S ribosome stalled close to the mutated SARS-CoV-2 slippery site by a pseudoknot (high resolution); 5S rRNA 7o7y B8 156 2.2 RF00002 URS00023119A4_9986 34029205 0003735 0005840 9986 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauuncaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<<<<....>>>>.....<.<<<......>>.............>>>..>...>>>....<<....>><<<<<<<<<.....>>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))(((((((((.....))))))))).................... Rabbit 80S ribosome stalled close to the mutated SARS-CoV-2 slippery site by a pseudoknot (high resolution); 5.8S rRNA 7o7z A2 1770 2.4 RF01960,RF01959,RF00177 URS00023119C9_9986 34029205 0003735 0005840 9986 uaccugguugauccugccaguagcaunugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucnuuaaaucaguuauggunccuunggucgcucguacuuggauaacugugguanuucuagngcuaananaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucagaucaaaaccaacccggugccggcggcuuuggugacucuagauaaccucgggccgaucgcacgcccuccguggcggcgacgacccauucgaacgucngcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgaunccggaganggagccugagaaacggcuaccacauncaaggnaggcagcaggcgcgcnaauuacccacucccgacccggggangungugangaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaanuccuuuaacgaggnuccauuggagngcaagucuggugccagcagccgcggnaauuccagcuccaauancguauauuaaaguugcugcaguunaaaagcucguaguungaucuugggagcgggcggccgcccguccccgccucucggcgccccggggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaaungaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagancgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacncaacacgggaaaccucacccggcccggacacggacagganugacagauugauagcucuuucucgauuccguggguggngnugcauggcnguucuuaguugguggagcgauuugucugguuaauuccgauaacgancgagacunuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuncuuanagggacaaguggcguucagccacccgagauugagcaauaacangucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgagnaauucccaguaagugcgggucauaagcuugcguugauunagucccugcccuuuguacacaccgnccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggucggcccacggcccuggcggagcgcugagaagacggucgaacungacuaucuagaggaaguaaaagucguancaagguuucnguaggugnnccugcggaaggaucauua ...<<<<<...[[[[>>>>>[[[.((((((.....{{.........[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[......{{....[[[[[.........<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<<<....>>>>>>...>>>>[[..(((((.....<<<<<<<<<<<<<..>>>>.......<......>..)))))......]]...<<<<.<<<<......>>>>>>>>.]].]]]...}}....]]].<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<<...>>>>..>>>......}}.......<<<<<<<<<.<<<....>>>..>>>>>>.>>>......<<..<...........>..>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..)))))).]]]............{{.......{{...[[[.[[....<<<.<<<<<<<..>>>>>>>.>>><<...<<<..<<<<<>>>>>.>>>.>>..<<<<<<.<.......<<...<.......>.<<<<.......>>>>...>>......>.>>>..>>>........{.[[.(((((((.....>>>>>>>>>.))))))).]].}....]]....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<<....>>>>>>>>>>>.>..>>>...<<..}}>>...>>.....>>>.....<<<......<<<......>>>....>>>..]]]]..<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<........<<........>>..........<<<<<......<<<<<<.......<<.<<<........>>>.>>.....>>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<.......>>>>.>>>>.....>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>>......>>>>>......>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<<<<<<<<<<<<<<.....>>>>>>>>>>>>.>.>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))((...(((((......(..((.....(((.(((..((....((....((..........))...)){))......(((.......(((.(.(..((....(((.....(({...((.....((.(((.....))).))......))......)).((((...(((((......)))))...))))((..(((((.....[[[[[[[[[.(((())))........(......)..)))))......)).(}((((.((((......)))))))))...)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)...)........(((((((((.(((....)))..)))))).)))....(.((..(...........)..))......)..((((([[....(.(.((.....((..]])).......)).)))))))..)))))...))..{......(.({{...(.(.((...(.(..(....(((.(((((((()))))))).)))((.....((.((((()))))))...))..(..(((.(........(..((.......)).((((...)..)))....).......).)))....)........(.((.(((((((.....]]]]]]]]].))))))).)).)....)....(((.((...(...(((...((..((((((((...(..........)......))))))))..)).......((....))....)))..)...))..))..)).)...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..(.((((((.(((((....))))))))))).)..)))...((..}}))...))...}.))))).).(((......((.(....).))....)))...]]].]((((..(((((((..((..((.((..(((..(((((.......(........)...........(((((.(....(((((.....(..(..(((........)))..)....).)))))...((.(((...(.((((((.(..((..(((((....)))..(.((......)))...))..))....(((...(...((.(..(((((((((((((....).)))).)))).....))))..).))..).....(((((.....)))))........))).)..))).))).....).))))).....).)))))...)).)))..))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....((((............)))).....)..)..)).)).....((((((((.......))))))))......))...))))))).)).))..(.(..((.(..((((.((..(.((((((((.(((..((((.((...((((((.(((((((((((.....)))))))))))..).)))))...)).))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>........ Rabbit 80S ribosome stalled close to the mutated SARS-CoV-2 slippery site by a pseudoknot (classified for pseudoknot); 18S rRNA 7o7z AH 95 2.4 RF00507 URS0002617719_2697049 34029205 0075523 2697049 gcacaaucguuuuuauaaggguuugcgguguaagugcagcccgucuuacaccgugcggcacaggcacuaguacugaugucguauacagggcuuuu .........................<<<<<<<<<...(((((..>>>>>>>>>.<<<<<<<<<<......>.>>>.>>>>>>.....)))))... .........................(((((((((...[[[[[..)))))))))((((((((((((....)).))).)))))))....]]]]]... Rabbit 80S ribosome stalled close to the mutated SARS-CoV-2 slippery site by a pseudoknot (classified for pseudoknot); mRNA containing SARS-CoV-2 sequence 7o7z AI 76 2.4 34029205 9913 nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnncca ............................................................................ ............................................................................ Rabbit 80S ribosome stalled close to the mutated SARS-CoV-2 slippery site by a pseudoknot (classified for pseudoknot); E-site tRNA 7o7z AT 76 2.4 RF00005 URS00001CE4E0_9913 34029205 0030533 0006412 9913 gccgaaauancucngnngggagagcnuuaganunaanaucuaaagnucncuggnucgnucccggguuucggcacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..))))...((.........)).......(((((..]....)))))))))))).... Rabbit 80S ribosome stalled close to the mutated SARS-CoV-2 slippery site by a pseudoknot (classified for pseudoknot); P-site Phe-tRNA(Phe) 7o7z B5 3764 2.4 RF02543,RF02540 URS000231197F_9986 34029205 0003735 0005840 9986 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcgguggggcgcgggaaauguggcguacggaagacccacuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagngngaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcgugguccggccgugccggcggucucggcggaucuuucccgcuccccguuccuggggguggggucggcgggggaccgccccccggccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggccccggcggggaagguggcccggggggacgccucgccgccgucguccgcggcggcggcgggcgcgaccccuccccggguguuacagccccgccccggcagcagcagcucgccgaaucccggggccgagggagcgagaccugugucgccgcgcucuccccccucgggggggccgggccgccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgugucacgccgucgggcucgggggaggccacggcgcgucgcgcgccggcgcgcgcgcgcgagcgagcgcacggggucggcggcgaugucggcuacccacccgacccnucuugnaacncggaccaaggagunuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcggcggcgccgucgucggccgaggugggaucccgaggcccuuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccnanagauggugancuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauagnggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcaaccccgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcngaacuggcgnugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgcuggcagucggcagagcgagaaagagaguggagccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaunuuggugguagunnnaaauauucaaacgagaacuuugaaggccgaaguggngaaggguuccaugngaacagnanuugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucagccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccnuauccgcagcaggucuncaaggugaacngccucuggnauguuggaacaanguagguaagggaagucggcaagcnggauccguaacuucnggauaaggauuggcucuaagggcugguagcagccgacuuagaacuggugcggaccaggngaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugccnagugcucugaaugucanagugangaaauucaaugaagcgcggnuaaacggcgggaguancuaugacucucuuaagguagcnaanugccucnucaucuaauuagugangcgcaugaanggaugancgagnuucccacugunccuaccuacuauccagcgaaaccacngncaagggaacgggcuuggnggaaucagcggngaaagaagacccuguugagcuugacncuagucuggcacggugaanagacaugagagguguagaauaagugggaggcccgggccgccggugaaauaccacuacucuuaucguuuuuucacugacccggugaggcgggggggcgagccccgaggggcucucgcuucuggcgccaagcgccgggccccgucgguccgggccggcggcggccgggcgcgacccgcuccggggacagugccagguggggaguuugacugnggcgguacaccugucaaacgguancgcaggnnuccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucagnacgaauacagaccgugaaagcggggccucacgauccuucugagcuuuuggguuuuaagcaggangugucagaaaaguuaccacagngauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuungaugucggnucuuccuaucauugugaagcagaauucaccaagcguungaunnuucacccacuaauagggaacgugngcugggnuuagancgucgugagacagguuaguuuuacccuacugaugnuguguuguugccaugguanuccugcucaguacgagaggaaccgcagnuncanacauuugguguaunugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgaaggagccucgguuggccucggauagccggucccccgcgggguccggugcggagagcccuucgucccgggaaauggggcgcggccggaaagggggccgcccucucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>>..<<<<<<<<<....<<<<<<<<.<<<....<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>>>>>>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<<....<<<<<<<.<<<<<.<.....<<<<<.<<<..<<<<<<<<<<<<<<<..>>>>>>>>>..>>>>>>>>>>>>>>.>>>>>>>>>>...>>>.>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<.<<<<<<<<<<<<<<<...<<..<<<..<<<<<<<......<<<<<<<<<<....<<<<<<<<<<<<<<..>>>>>>>>>>>>>>........>>>>>>>>>>.......>>>>>>>..>>>.........>>>>>>..>>>>>>>>>>>.....<<.....[[>>......<<<<<..<<<<<<<.>>>>>>>.<<<<<<.<<<<.<<<<<<<<<.<<<<<<<<<<<<<<.<<<<....>>>>.>>>>>>>>>>>.>>>.>>>>>>.>>>...>>>>..>>>>.>><<<<<.<<<<<<<..>>>>>>>>>>>>.....>>>>>......>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<<<<...<<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<<<<<<..>>>>>>>>>>>>..<<<<<...<<<..<<....((((.{{..>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>>.<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<..........<<<.<<<<<<<<<...<<<....<<<..<.<<<..<<<<<<.<.....>.>>>>>>>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.........>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<.......]]...........}}.))))..............>>>>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<<<<<...>>>>>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<..<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<....>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<<<<<<<<<<<..........<<<<<..<<<<..>>>>............>>>>>.>>>>>>>.>>>>>>>>>>...<<<<<.....<<<<..<<.<<<<<<<..>>>>>>>>>..............<<<<<.<<<<.<<<<<<<<..>>>>>>>>..>>>>.>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>><<<<....>>>>>>)))].....<<<<<<<..<<<..)))))).>>>>>>>>>>.........>>>>..>>>>>>.......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<.]]]..>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.....<<<<<<<..<<..<<<<....<<<........<<<<<..<<<<..>>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<........>>>>>>>>>>...>>>>..>>>..............>>>>..>>>>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<.<..<<<<<......>>>>>..>>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..(((((((((((.....)))))).))))....))))....(((((((((....((((((((.((.....((((((((..({((((......)))))....[[(...).(((....}]])))...).))))))).))))))))))...)))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....((((((((((.(..(((((((.(((((.((....(((((.(((..(((((((.(((((((()))))))).)..)))))))))))))))))))))))))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((..(((((((......((((((((((...((((((((((((((....))))))))))))).)......)))))))))).......)))))))..))).........))))))..))))))))))).....((.....{{))......((((((.(((((((.))))))).((((((.((((.(((((((((.((((((((((((((.((((....)))).))))))))))).))).)))))).)))...))))..)))).))(((((.(((((((()))))))))))))..[.)))))).....))).)))))...)))))...)))))))).<((((........))))((((((....(((((((((((((..(((..(((((........))))..)..)))...((....))...((((((((((((()))))))))))))..(((((...(((..((.(].[[[[.[[[)))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......B)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((..........(((.((((((((.....((.....((.....((..((((((.(.....).)))))))).....))...))......))))))...(((((((((.(......))))))))))....))))))))))))..))..((((..(.((.....)).)..))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.....A.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((.......}}.........].]].]]]].(...)........)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((..(((((((...((.....)).))))))....[[(((.((...(.....(((....)))...(.)....((.(((((((((...))))))))))).......)....))...(((((........)))))]]((((....(((((...((.((((....)))).))..((((....)))...(...((((((...((((((((((((((((((((((....{{...)))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).))).))).....((......)).)))).((((.....))))..)))....(((......((((((..((..(....(.......(((((....(.[..).....)))))((.(((((((((((....)))))..)))))).))(...).......(((((((((.>.(...........)...(((((((....((((.....))))......))))))).].(.(.(((..((((((.(...(......((.(....).))......).)))))..)))))(.(.(.........).).)........((..........(((((.......)))))..)..)....).)....)).))))))).)..)))..))))))...)))))....)).[..((.((.....>].)).))....(((((..(((.((......((((.(((((...(((((.(((((((((.(((((((((((((((((.......[..(((((..((((()))))..........].))))).))))))).))))))))))...(((((.....((((..((.(((((((..)))))))))..............(((((.(((((((((((((()))))))))).)))).)))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(..((....((....{..))....)).)(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}.....)))..)))))).......(....(.((((.(...((.......))...).))))...)....)........((((.((((((..(.(.(.(((......))).)...).).(((.(.....).))).....)))))..)...))).)......((((((....))).)))...b.))..))).))))).....(.((.(.(..(((..(.(((((......(....).....))))).)(((.....((((....((.(((((((}}..)))))..)).))...))))....))).((((...((((.....a.......))))...))))..)))...).).)).).....(((((((..((..((((.(..(((.........((((..((((())))).))))........)))...(((..((((....((((.((((((........))))))))))...))))..)))...........)..))))..)))))))))(((((....(.......).......((.(((((((.((.....(.((.(..(((((......)))))..))).)....))....)))).))).))..))))).. Rabbit 80S ribosome stalled close to the mutated SARS-CoV-2 slippery site by a pseudoknot (classified for pseudoknot); 28S rRNA 7o7z B7 120 2.4 RF00001 URS000002B0D5_9986 34029205 0003735 0005840 9986 nucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. Rabbit 80S ribosome stalled close to the mutated SARS-CoV-2 slippery site by a pseudoknot (classified for pseudoknot); 5S 7o7z B8 156 2.4 RF00002 URS00023119A4_9986 34029205 0003735 0005840 9986 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauuncaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<<<<....>>>>.....<.<<<......>>.............>>>..>...>>>....<<....>><<<<<<<<<.....>>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))(((((((((.....))))))))).................... Rabbit 80S ribosome stalled close to the mutated SARS-CoV-2 slippery site by a pseudoknot (classified for pseudoknot); 5.8S rRNA 7o80 A2 1770 2.9 RF01960,RF01959,RF00177 URS00023119C9_9986 34029205 0003735 0005840 9986 uaccugguugauccugccaguagcaunugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucnuuaaaucaguuauggunccuunggucgcucguacuuggauaacugugguanuucuagngcuaananaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucagaucaaaaccaacccggugccggcggcuuuggugacucuagauaaccucgggccgaucgcacgcccuccguggcggcgacgacccauucgaacgucngcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgaunccggaganggagccugagaaacggcuaccacauncaaggnaggcagcaggcgcgcnaauuacccacucccgacccggggangungugangaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaanuccuuuaacgaggnuccauuggagngcaagucuggugccagcagccgcggnaauuccagcuccaauancguauauuaaaguugcugcaguunaaaagcucguaguungaucuugggagcgggcggccgcccguccccgccucucggcgccccggggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaaungaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagancgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacncaacacgggaaaccucacccggcccggacacggacagganugacagauugauagcucuuucucgauuccguggguggngnugcauggcnguucuuaguugguggagcgauuugucugguuaauuccgauaacgancgagacunuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuncuuanagggacaaguggcguucagccacccgagauugagcaauaacangucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgagnaauucccaguaagugcgggucauaagcuugcguugauunagucccugcccuuuguacacaccgnccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggucggcccacggcccuggcggagcgcugagaagacggucgaacungacuaucuagaggaaguaaaagucguancaagguuucnguaggugnnccugcggaaggaucauua ...<<<<<...[[[[>>>>>[[[.((((((.....{{.........[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[......{{....[[[[[.........<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<<<....>>>>>>...>>>>[[..(((((.....<<<<<<<<<<<<<..>>>>.......<......>..)))))......]]...<<<<.<<<<......>>>>>>>>.]].]]]...}}....]]].<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<<...>>>>..>>>......}}.......<<<<<<<<<.<<<....>>>..>>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..)))))).]]]............{{.......{{...[[[.[[....<<<.<<<<<<<..>>>>>>>.>>><<...<<<<.<<<<<>>>>>>>>>.>>..<<<<<<.<.......<<...<.......>.<<<<.......>>>>...>>......>.>>>..>>>........{.[[.(((((((.....>>>>>>>>>.))))))).]].}....]]....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<<....>>>>>>>>>>>.>..>>>...<<..}}>>...>>.....>>>.....<<<......<<<......>>>....>>>..]]]]..<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<........<<........>>..........<<<<<......<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<.......>>>>.>>>>.....>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.......>>>>>......>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<<<<<<<<<<<<<<.....>>>>>>>>>>>>.>.>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))((...(((((......(..((.....(((.(((..((....((....((..........))...)){))......(((.......(((.(....((....(((.....(({...((.....((.(((.....))).))......))......)).((((...((((((....))))))...))))((..(((((.....[[[[[[[[[.(((())))........(......)..)))))......)).(}((((.((((......)))))))))...)))...))..).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)...)........(((((((((.(((....)))..)))))).)))....(.((..(...........)..))......)..((((([[....(.(.((.....((..]])).......)).)))))))..)))))...))..{......(.({{...(.(.((...(.(..(....(((.(((((((()))))))).)))((...((((.((((())))))))).))..(..(((.(........(..((.......)).((((...)..)))....).......).)))....)........(.((.(((((((.....]]]]]]]]].))))))).)).)....)....(((..(...(...(((...((..((((((((...(..........)......))))))))..)).......((....))....)))..)...)...))..)).)...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..(.((((((.(((((....))))))))))).)..)))...((..}}))...))...}.))))).).(((......((.(....).))....)))...]]].]((((..(((((((..((..((.((..(((..(((((.......(........)...........(((((.(....(((((.....(..(..(((........)))..)....).)))))...((.(((...(.((((((.(..((..(((((....)))..(.((......)))...))..))....(((...(...((.(..(((((((((((((....).)))).)))).....))))..).))..).....(((((.....)))))........))).)..))).))).....).))))).....).)))))...)).)))..))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....((((............)))).....)..)..)).)).....((((((((.......))))))))......))...))))))).)).))..(.(..((.(..((((.((..(.((((((((.(((..((((.((...(((((.((((((((((((.....))))))))))))...)))))...)).))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>........ Rabbit 80S ribosome in complex with eRF1 and ABCE1 stalled at the STOP codon in the mutated SARS-CoV-2 slippery site; 18S rRNA 7o80 AH 24 2.9 RF00507 URS0002617731_2697049 34029205 0075523 2697049 caaucguuuuuauaaggguuugcg ........................ ........................ Rabbit 80S ribosome in complex with eRF1 and ABCE1 stalled at the STOP codon in the mutated SARS-CoV-2 slippery site; mRNA containing SARS-CoV-2 sequence 7o80 AI 76 2.9 34029205 9913 nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnncca ............................................................................ ............................................................................ Rabbit 80S ribosome in complex with eRF1 and ABCE1 stalled at the STOP codon in the mutated SARS-CoV-2 slippery site; E-site tRNA 7o80 AT 86 2.9 RF00005 URS00023119CA_9913 34029205 0030533 0006412 9913 accgggauggccgagugguuaaggcguuggacuuaagauccaaugggcuagugcccgcgugggnucgaaccccacucucgguacca <<<<<<<..<<<..........>>><<<<<<.......>>>>>>.<<<....>>>...<<<<<.......>>>>>>>>>>>>.... ((((.((..(((.....[....))).(((((.......)))))..(((....)))...(((((..]....))))))).)))).... Rabbit 80S ribosome in complex with eRF1 and ABCE1 stalled at the STOP codon in the mutated SARS-CoV-2 slippery site; P-site Leu-tRNA(Leu) 7o80 B5 3764 2.9 RF02543,RF02540 URS000231197F_9986 34029205 0003735 0005840 9986 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcgguggggcgcgggaaauguggcguacggaagacccacuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagngngaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcgugguccggccgugccggcggucucggcggaucuuucccgcuccccguuccuggggguggggucggcgggggaccgccccccggccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggccccggcggggaagguggcccggggggacgccucgccgccgucguccgcggcggcggcgggcgcgaccccuccccggguguuacagccccgccccggcagcagcagcucgccgaaucccggggccgagggagcgagaccugugucgccgcgcucuccccccucgggggggccgggccgccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgugucacgccgucgggcucgggggaggccacggcgcgucgcgcgccggcgcgcgcgcgcgagcgagcgcacggggucggcggcgaugucggcuacccacccgacccnucuugnaacncggaccaaggagunuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcggcggcgccgucgucggccgaggugggaucccgaggcccuuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccnanagauggugancuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauagnggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcaaccccgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcngaacuggcgnugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgcuggcagucggcagagcgagaaagagaguggagccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaunuuggugguagunnnaaauauucaaacgagaacuuugaaggccgaaguggngaaggguuccaugngaacagnanuugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucagccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccnuauccgcagcaggucuncaaggugaacngccucuggnauguuggaacaanguagguaagggaagucggcaagcnggauccguaacuucnggauaaggauuggcucuaagggcugguagcagccgacuuagaacuggugcggaccaggngaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugccnagugcucugaaugucanagugangaaauucaaugaagcgcggnuaaacggcgggaguancuaugacucucuuaagguagcnaanugccucnucaucuaauuagugangcgcaugaanggaugancgagnuucccacugunccuaccuacuauccagcgaaaccacngncaagggaacgggcuuggnggaaucagcggngaaagaagacccuguugagcuugacncuagucuggcacggugaanagacaugagagguguagaauaagugggaggcccgggccgccggugaaauaccacuacucuuaucguuuuuucacugacccggugaggcgggggggcgagccccgaggggcucucgcuucuggcgccaagcgccgggccccgucgguccgggccggcggcggccgggcgcgacccgcuccggggacagugccagguggggaguuugacugnggcgguacaccugucaaacgguancgcaggnnuccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucagnacgaauacagaccgugaaagcggggccucacgauccuucugagcuuuuggguuuuaagcaggangugucagaaaaguuaccacagngauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuungaugucggnucuuccuaucauugugaagcagaauucaccaagcguungaunnuucacccacuaauagggaacgugngcugggnuuagancgucgugagacagguuaguuuuacccuacugaugnuguguuguugccaugguanuccugcucaguacgagaggaaccgcagnuncanacauuugguguaunugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgaaggagccucgguuggccucggauagccggucccccgcgggguccggugcggagagcccuucgucccgggaaauggggcgcggccggaaagggggccgcccucucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>>..<<<<<<<<<....<<<<<<<<.<<<....<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>>>>>>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<<.<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<<....<<<<<<<.<<<<<.<.....<<<<<.<<<..<<<<<<<<<<<<<<<..>>>>>>>>>..>>>>>>>>>>>>>>.>>>>>>>>>>...>>>.>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<.<<<<<<<<<<.<<<<...<<..<<<..<<<<<<<......<<<<<<<<<<....<<<<<<<<<<<<<<..>>>>>>>>>>>>>>........>>>>>>>>>>.......>>>>>>>..>>>.........>>>>>>...>>>>>>>>>>.....<<.....[[>>......<<<<<..<<<<<<<.>>>>>>>.<<<<<<.<<<<.<<<<<<<<<.<<<<<<<<<<<<<<.<<<<....>>>>.>>>>>>>>>>>.>>>.>>>>>>.>>>...>>>>..>>>>.>><<<<<.<<<<<<<..>>>>>>>>>>>>.....>>>>>......>>.>>>>>...>>>>>.>.>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<<<<<<..>>>>>>>>>>>>..<<<<<...<<<..<<....((((.{{..>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<..........<<<.<<<<<<<<<...<<<....<<<....<<<..<<<<<<.<.....>.>>>>>>>>>....>>>..>.>>...>>>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<.......]]...........}}.))))..............>>>>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<<<<<...>>>>>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<...<<<<<<<....>>>>>>>...<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<....>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<<<<<<<<<<<..........<<<<<..<<<<..>>>>............>>>>>.>>>>>>>.>>>>>>>>>>...<<<<<.....<<<<..<<.<<<<<<<..>>>>>>>>>..............<<<<<.<<<<.<<<<<<<<..>>>>>>>>..>>>>.>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>><<<<....>>>>>>)))].....<<<<<<<..<<<..)))))).>>>>>>>>>>.........>>>>..>>>>>>.......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<.<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>..>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<]]].>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.....<<<<<<<..<<..<<<<....<<<........<<<<<..<<<<..>>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<........>>>>>>>>>>...>>>>..>>>..............>>>>..>>>>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<.<..<<<<<......>>>>>..>>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..(((((((((((.....)))))).))))....))))....(((((((((....(((((((.(((.....((((((((..({((((......)))))....[[(...).(((....}]])))...).))))))).))))))))))...)))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((((((.(((.((...((((((((.(((.....((((((((((.(..(((((((.(((((.((....(((((.(((..(((((((.(((((((()))))))).)..)))))))))))))))))))))))))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((..(((((((......((((((((((...((((((((((((((....))))))))))))).)......)))))))))).......)))))))..))).........))))))..))))))))))).....((.....{{))......((((((.(((((((.))))))).((((((.((((.(((((((((.((((((((((((((.((((....)))).))))))))))).))).)))))).)))...))))..)))).))(((((.(((((((()))))))))))))..[.)))))).....))).)))))...))))).).)))))))).<((((........))))((((((....(((((((((((((..(((..((((..........)))..)..)))...((....))...((((((((((((()))))))))))))..(((((...(((..((.(].[[[[.[[[)))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((........)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((..........(((.((((((((.....((.....((.....((..((((((.(.....).)))))))).....))...))......))))))...(((((((((.(......))))))))))....))))))))))))..))..((((..(.((.....)).)..))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.....A.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((.......}}.........].]].]]]].(...)........)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((..(((((((...((.....)).))))))....[[(((.((...(.....(((....)))...(.)....((.((((.((((...)))).)))))).......)....))...(((((........)))))]]((((....(((((...((.((((....)))).))..((((....)))...(...((((((...((((((((((((((((((((((....{{...)))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).))).))).....((......)).)))).((((.....))))..)))....(((......((((((..((..(....(.......(((((....(.[..).....)))))((.(((((((((((....)))))..)))))).))(...).......(((((((((.>.(...........)...(((((((....((((.....))))......))))))).].(.(.(((..((((((.(...(......((.(....).))......).)))))..)))))(.(.(.........).).)........((..........(((((.......)))))..)..)....).)....)).))))))).)..)))..))))))...)))))....)).[..((.((.....>].)).))....(((((..(((.((......((((.(((((...(((((.(((((((((.(((((((.(((((((((.......[..(((((..((((()))))..........].))))).))))))).)).)))))))...(((((.....((((..((.(((((((..)))))))))..............(((((.((((..(((((((())))))))...)))).)))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(..((....((....{..))....)).)(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}.....)))..)))))).......(....(.((((.(...((.......))...).))))...)....)........((((.((((((..(.(.(.(((......))).)...).).(((.(.....).))).....)))))..)...))).)......((((((....))).))).....))..))).))))).....(.((.(.(..(((..(.(((((......(....).....))))).)(((.....((((....((.(((((((}}..)))))..)).))...))))....))).((((...((((.....a.......))))...))))..)))...).).)).).....(((((((..((..((((.(..(((.........((((..((((())))).))))........)))...(((..((((....((((.((((((........))))))))))...))))..)))...........)..))))..)))))))))(((((....(.......).......((.(((((((.((.....(.((.(..(((((......)))))..))).)....))....)))).))).))..))))).. Rabbit 80S ribosome in complex with eRF1 and ABCE1 stalled at the STOP codon in the mutated SARS-CoV-2 slippery site; 28S rRNA 7o80 B7 119 2.9 RF00001 URS000231198C_9986 34029205 0003735 0005840 9986 ucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>... ((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))... Rabbit 80S ribosome in complex with eRF1 and ABCE1 stalled at the STOP codon in the mutated SARS-CoV-2 slippery site; 5S rRNA 7o80 B8 156 2.9 RF00002 URS00023119A4_9986 34029205 0003735 0005840 9986 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauuncaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<<<<....>>>>.....<.<<<......>>.............>>>..>...>>>....<<....>><<<<<<<<<.....>>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))(((((((((.....))))))))).................... Rabbit 80S ribosome in complex with eRF1 and ABCE1 stalled at the STOP codon in the mutated SARS-CoV-2 slippery site; 5.8S rRNA 7o81 A2 1770 3.1 RF01960,RF01959,RF00177 URS00023119C9_9986 34029205 0003735 0005840 9986 uaccugguugauccugccaguagcaunugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucnuuaaaucaguuauggunccuunggucgcucguacuuggauaacugugguanuucuagngcuaananaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucagaucaaaaccaacccggugccggcggcuuuggugacucuagauaaccucgggccgaucgcacgcccuccguggcggcgacgacccauucgaacgucngcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgaunccggaganggagccugagaaacggcuaccacauncaaggnaggcagcaggcgcgcnaauuacccacucccgacccggggangungugangaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaanuccuuuaacgaggnuccauuggagngcaagucuggugccagcagccgcggnaauuccagcuccaauancguauauuaaaguugcugcaguunaaaagcucguaguungaucuugggagcgggcggccgcccguccccgccucucggcgccccggggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaaungaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagancgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacncaacacgggaaaccucacccggcccggacacggacagganugacagauugauagcucuuucucgauuccguggguggngnugcauggcnguucuuaguugguggagcgauuugucugguuaauuccgauaacgancgagacunuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuncuuanagggacaaguggcguucagccacccgagauugagcaauaacangucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgagnaauucccaguaagugcgggucauaagcuugcguugauunagucccugcccuuuguacacaccgnccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggucggcccacggcccuggcggagcgcugagaagacggucgaacungacuaucuagaggaaguaaaagucguancaagguuucnguaggugnnccugcggaaggaucauua ...<<<<<...[[[[>>>>>[[[.((((((.....{{.........[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[......{{....[[[[[.........<<.....<<.<<.......>>.>>......>>.........<<<<...<<<<<<....>>>>>>...>>>>[[..(((((.....<<<<<<<<<<<<<..>>>>.......<......>..)))))......]]...<<<<.<<<<......>>>>>>>>.]].]]]...}}....]]].<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<<...>>>>..>>>......}}.......<<<<<<<<<.<<<....>>>..>>>>>>.>>>......<<..<...........>..>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..)))))).]]]............{{.......{{...[[[.[[....<<<.<<<<<<<..>>>>>>>.>>><<...<<<<.<<<<..>>>>>>>>.>>..<<<<<<.<.......<<...<.......>.<<<<.......>>>>...>>......>.>>>..>>>........{.[[.(((((((.....>>>>>>>>>.))))))).]].}....]]....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<<....>>>>>>>>>>>.>..>>>...<<..}}>>...>>.....>>>.....<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<.......<<........>>..........<<<<<......<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<.......>>>>.>>>>.....>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.......>>>>>....>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<<<<<<<<<<<<<<.....>>>>>>>>>>>>.>.>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))((...(((((......(..((.....(((.(((..((....((....((..........))...)){))......(((.......(((.(....((....(((.....(({...((.....((.(((.....))).))......))......)).((((...((((((....))))))...))))((..(((((.....[[[[[[[[..(((())))........(......)..)))))......)).(}((((..(((......))).)))))...)))...))..).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)...)........(((((((((.(((....)))..)))))).)))....(.((..(...........)..))......)..((((([[....(.(.((.....((..]])).......)).)))))))..)))))...))..{......(.({{...(.(.((...(.(.......(((.(((((((()))))))).)))((.(.((((.((((())))))))))))..(..(((.(........(..((.......)).((((...)..)))....).......).)))....)........(.((.(((((((......]]]]]]]].))))))).)).).........(((..(...(...(((...((..((((((((...(..........)......))))))))..)).......((....))....)))..)...)...))..)).)...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..(.((((((.(((((....))))))))))).)..)))...((..}}))...))...}.))))).).(((......((.(....).))....)))...]]].]((((..(((((((..((..((.((..(((..(((((.......(........)...........(((((.(....(((((.....(..(..(((........)))..)....).)))))...((.(((...(.((((((....((..(((((....)))..(.((......)))...))..))....(((...(...((.(..(((((((((((((....).)))).)))).....))))..).))..).....(((((.....)))))........)))....))).))).....).))))).....).)))))...)).)))..))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....((((............)))).....)..)..)).)).....((((((((.......))))))))......))...))))))).)).))..(.(..((.(..((((.((..(.(((((((..(((..((((.((...((((((.((((.((((((.....)))))).))))..).)))))...)).))))..)))..))))))))..)).))))...).))...)..)..(((((((((....)))))))))>........ Rabbit 80S ribosome colliding in another ribosome stalled by the SARS-CoV-2 pseudoknot; 18S rRNA 7o81 AH 10 3.1 RF00507 URS0002617731_2697049 34029205 0075523 2697049 gaacccaugc .......... .......... Rabbit 80S ribosome colliding in another ribosome stalled by the SARS-CoV-2 pseudoknot; mRNA containing SARS-CoV-2 sequence 7o81 AJ 76 3.1 RF00005 URS0002311A15_9913 34029205 0030533 0006412 9913 gccuucuuagcgcaguaggcagcgcgucagucucauaaucugaagguccugagnucgagccucagagagggcacca <<<<<<<..<<<<........>>>>.<<<<.........>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((.........)))).....(((((..]....)))))))))))).... Rabbit 80S ribosome colliding in another ribosome stalled by the SARS-CoV-2 pseudoknot; A-site Met-tRNA(Met) 7o81 AT 75 3.1 RF00005 URS0000416117_9913 34029205 0030533 0006412 9913 ggcucguuggucuagggguaugauucucgcuuagggugcgagaggucccgggnucaaaucccggacgagccccca <<<<<<<...<<.........>><<<<<<<.......>>>>>>>...<<<<<.......>>>>>>>>>>>>.... (((((((..(((.....[...)))((((((.......))))))....(((((..]....)))))))))))).... Rabbit 80S ribosome colliding in another ribosome stalled by the SARS-CoV-2 pseudoknot; P-site tRNA(Pro) 7o81 B5 3764 3.1 RF02543,RF02540 URS000231197F_9986 34029205 0003735 0005840 9986 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcgguggggcgcgggaaauguggcguacggaagacccacuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagngngaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcgugguccggccgugccggcggucucggcggaucuuucccgcuccccguuccuggggguggggucggcgggggaccgccccccggccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggccccggcggggaagguggcccggggggacgccucgccgccgucguccgcggcggcggcgggcgcgaccccuccccggguguuacagccccgccccggcagcagcagcucgccgaaucccggggccgagggagcgagaccugugucgccgcgcucuccccccucgggggggccgggccgccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgugucacgccgucgggcucgggggaggccacggcgcgucgcgcgccggcgcgcgcgcgcgagcgagcgcacggggucggcggcgaugucggcuacccacccgacccnucuugnaacncggaccaaggagunuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcggcggcgccgucgucggccgaggugggaucccgaggcccuuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccnanagauggugancuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauagnggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcaaccccgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcngaacuggcgnugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgcuggcagucggcagagcgagaaagagaguggagccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaunuuggugguagunnnaaauauucaaacgagaacuuugaaggccgaaguggngaaggguuccaugngaacagnanuugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucagccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccnuauccgcagcaggucuncaaggugaacngccucuggnauguuggaacaanguagguaagggaagucggcaagcnggauccguaacuucnggauaaggauuggcucuaagggcugguagcagccgacuuagaacuggugcggaccaggngaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugccnagugcucugaaugucanagugangaaauucaaugaagcgcggnuaaacggcgggaguancuaugacucucuuaagguagcnaanugccucnucaucuaauuagugangcgcaugaanggaugancgagnuucccacugunccuaccuacuauccagcgaaaccacngncaagggaacgggcuuggnggaaucagcggngaaagaagacccuguugagcuugacncuagucuggcacggugaanagacaugagagguguagaauaagugggaggcccgggccgccggugaaauaccacuacucuuaucguuuuuucacugacccggugaggcgggggggcgagccccgaggggcucucgcuucuggcgccaagcgccgggccccgucgguccgggccggcggcggccgggcgcgacccgcuccggggacagugccagguggggaguuugacugnggcgguacaccugucaaacgguancgcaggnnuccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucagnacgaauacagaccgugaaagcggggccucacgauccuucugagcuuuuggguuuuaagcaggangugucagaaaaguuaccacagngauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuungaugucggnucuuccuaucauugugaagcagaauucaccaagcguungaunnuucacccacuaauagggaacgugngcugggnuuagancgucgugagacagguuaguuuuacccuacugaugnuguguuguugccaugguanuccugcucaguacgagaggaaccgcagnuncanacauuugguguaunugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgaaggagccucgguuggccucggauagccggucccccgcgggguccggugcggagagcccuucgucccgggaaauggggcgcggccggaaagggggccgcccucucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>>..<<<<<<<<<....<<<<<<<.<<<<....<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>>>>>>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<<....<<<<<<<.<<<<<.<.....<<<<<.<<<..<<<<<<<<<<<<<<<..>>>>>>>>>..>>>>>>>>>>>>>>.>>>>>>>>>>...>>>.>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<.<<<<<<<<<<.<<<<...<<..<<<..<<<<<<<......<<<<<<<<<<....<<<<<<<<<<<<<<..>>>>>>>>>>>>>>........>>>>>>>>>>.......>>>>>>>..>>>.........>>>>>>...>>>>>>>>>>.....<<.....[[>>......<<<<<<.<<<<<<<.>>>>>>>.<<<<<<.<<<<.<<<<<<<<<.<<<<<<<<<<<<<<.<<<<....>>>>.>>>>>>>>>>>.>>>.>>>>>>.>>>...>>>>..>>>>.>><<<<<.<<<<<<<..>>>>>>>>>>>>....>>>>>>......>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<<<<...<<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<<<<<<..>>>>>>>>>>>>..<<<<<...<<<..<<....((((.{{..>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>>.<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<..........<<<.<<<<<<<<<...<<<....<<<..<.<<<..<<<<<<.<.....>.>>>>>>>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<.......]]...........}}.))))..............>>>>>>>>>....>>>>>>...<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<<<<<...>>>>>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<..<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<....>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<..<<<.....<<<<....>>>>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<<<<<<<<<<<..........<<<<<..<<<<..>>>>............>>>>>.>>>>>>>.>>>>>>>>>>...<<<<<.....<<<<..<<.<<<<<<....>>>>>>>>..............<<<<<.<<<<<<<<<<<<<..>>>>>>>>>.>>>>.>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))].....<<<<<<<..<<<..)))))).>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<.]]]..>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.....<<<<<<<..<<..<<<<....<<<........<<<<<..<<<<..>>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<........>>>>>>>>>>...>>>>..>>>..............>>>>..>>>>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<.<..<<<<<......>>>>>..>>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..(((((((((((.....)))))).))))....))))....(((((((((....(((((((.(((.....((((((((..({((((......)))))....[[(...).(((....}]])))...).))))))).))))))))))...)))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....((((((((((.(..(((((((.(((((.((....(((((.(((..(((((((((((((((())))))))))..)))))))))))))))))))))))))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((..(((((((......((((((.(((...((((((((((((((....))))))))))))).)......))).)))))).......)))))))..))).........))))))..))))))))))).....((.....{{))......((((((.(((((((.))))))).((((((.((((.(((((((((.((((((((((((((.((((....)))).))))))))))).))).)))))).)))...))))..)))).))(((((.(((((((()))))))))))))..[.)))))).....))).)))))...)))))...)))))))).<((((........))))((((((....(((((((((((((..(((..(((((........))))..)..)))...((....))...((((((((((((()))))))))))))..(((((...(((..((.(].[[[[.[[[)))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......B)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((..........(((.((((((((.....((.....((.....((...(((((.........))))).)).....))...))......))))))...(((((((((.(......))))))))))....))))))))))))..))..((((..(.((.....)).)..))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.....A.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((.......}}.........].]].]]]].(...)........)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((..(((((((...((.....)).))))))....[[(((.((...(.....(((....)))...(.)....((.(((((((((...))))))))))).......)....))...(((((........)))))]]((((....(((((...((.((((....)))).))..((((....)))...(...((((((...((((((((((((.(((((((((....{{...)))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).)))))))))))...))))))))))))(...)....))))))...)).........)).))).)))).))).))).....((......)).)))).((((.....))))..)))....(((......((((((..((..(....(.......(((((....(.[..).....)))))((.(((((((((((....)))))..)))))).))(...).......(((((((((.>.(...........)...(((((((....((((.....))))......))))))).].(.(.(((..((((((.(...(......((.(....).))......).)))))..)))))(.(.(.........).).)........((..........(((((.......)))))..)..)....).)....)).))))))).)..)))..))))))...)))))....)).[..((.((.....>].)).))....(((((..(((.((......((((.(((((...(((((.(((((((((.(((((((((((((((((.......[..(((((..((((()))))..........].))))).))))))).))))))))))...(((((.....((((..((.(((((((..)))))))))..............(((((.(((((((((((((()))))))))).)))).)))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(..((....((....{..))....)).)(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}.....)))..)))))).......(....(.((((.(...((.......))...).))))...)....)........((((.((((((..(.(.(.(((......))).)...).).(((.(.....).))).....)))))..)...))).)......((((((....))).)))...b.))..))).))))).......((.(.(..(((..(.(((((......(....).....))))).)(((.....((((....((.(((((((}}..)))))..)).))...))))....))).((((...((((.....a.......))))...))))..)))...).).)).......(((((((..((..((((.(..(((.........((((..((((())))).))))........)))...(((..((((....((((.((((((........))))))))))...))))..)))...........)..))))..)))))))))(((((....(.......).......((.(((((((.((.....(.((.(..(((((......)))))..))).)....))....)))).))).))..))))).. Rabbit 80S ribosome colliding in another ribosome stalled by the SARS-CoV-2 pseudoknot; 28S rRNA 7o81 B7 120 3.1 RF00001 URS000002B0D5_9986 34029205 0003735 0005840 9986 nucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. Rabbit 80S ribosome colliding in another ribosome stalled by the SARS-CoV-2 pseudoknot; 5S rRNA 7o81 B8 156 3.1 RF00002 URS00023119A4_9986 34029205 0003735 0005840 9986 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauuncaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<<<<....>>>>.....<.<<<......>>.............>>>..>...>>>....<<....>><<<<<<<<<.....>>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))(((((((((.....))))))))).................... Rabbit 80S ribosome colliding in another ribosome stalled by the SARS-CoV-2 pseudoknot; 5.8S rRNA 7oav A 51 2.99 URS0002311967_32630 34112799 32630 gcuagcuggaggggcgccaguucgcuggugguugggugcggucggcuagcc <<<<<<<......<<<<<<<<..>>>>>>........>>....>>>>>>>. (((((((.(....(((((((....)))))........))...)))))))). Crystal structure of Chili RNA aptamer in complex with DMHBO+ (Iridium III hexammine soaking crystal form); Chili RNA Aptamer 7oav B 51 2.99 URS0002311967_32630 34112799 32630 gcuagcuggaggggcgccaguucgcuggugguugggugcggucggcuagcc <<<<<<<......<<<<<<<....>>>>>........>>....>>>>>>>. (((((((.(....(((((((....)))))........))...)))))))). Crystal structure of Chili RNA aptamer in complex with DMHBO+ (Iridium III hexammine soaking crystal form); Chili RNA Aptamer 7oav C 51 2.99 URS0002311967_32630 34112799 32630 gcuagcuggaggggcgccaguucgcuggugguugggugcggucggcuagcc <<<<<<<......<<<<<<<<..>>>>>>........>>....>>>>>>>. (((((((.(....(((((((....)))))........))...)))))))). Crystal structure of Chili RNA aptamer in complex with DMHBO+ (Iridium III hexammine soaking crystal form); Chili RNA Aptamer 7oav D 51 2.99 URS0002311967_32630 34112799 32630 gcuagcuggaggggcgccaguucgcuggugguugggugcggucggcuagcc <<<<<<<......<<<<<<<<..>>>>>>........>>....>>>>>>>. (((((((.(....(((((((....)))))........))...)))))))). Crystal structure of Chili RNA aptamer in complex with DMHBO+ (Iridium III hexammine soaking crystal form); Chili RNA Aptamer 7oaw A 51 2.95 URS0002311967_32630 34112799 32630 gcuagcuggaggggcgccaguucgcuggugguugggugcggucggcuagcc <<<<<<<......<<<<<<<<..>>>>>>........>>....>>>>>>>. (((((((.(....(((((((....)))))........))...)))))))). Crystal structure of the Chili RNA aptamer in complex with DMHBI+; Chili RNA Aptamer 7oaw B 51 2.95 URS0002311967_32630 34112799 32630 gcuagcuggaggggcgccaguucgcuggugguugggugcggucggcuagcc <<<<<<<......<<<<<<<....>>>>>........>>....>>>>>>>. (((((((.(....(((((((....)))))........))...)))))))). Crystal structure of the Chili RNA aptamer in complex with DMHBI+; Chili RNA Aptamer 7oaw C 51 2.95 URS0002311967_32630 34112799 32630 gcuagcuggaggggcgccaguucgcuggugguugggugcggucggcuagcc <<<<<<<......<<<<<<<....>>>>>........>>....>>>>>>>. (((((((.(....(((((((....)))))........))...)))))))). Crystal structure of the Chili RNA aptamer in complex with DMHBI+; Chili RNA Aptamer 7oaw D 51 2.95 URS0002311967_32630 34112799 32630 gcuagcuggaggggcgccaguucgcuggugguugggugcggucggcuagcc <<<<<<<......<<<<<<<....>>>>>........>>....>>>>>>>. (((((((.(....(((((((....)))))........))...)))))))). Crystal structure of the Chili RNA aptamer in complex with DMHBI+; Chili RNA Aptamer 7oax A 51 2.24 URS0002311967_32630 34112799 32630 gcuagcuggaggggcgccaguucgcuggugguugggugcggucggcuagcc <<<<<<<......<<<<<<<<..>>>>>>........>>....>>>>>>>. (((((((.(....(((((((....)))))........))...)))))))). Crystal structure of the Chili RNA aptamer in complex with DMHBO+; Chili RNA Aptamer 7oax B 51 2.24 URS0002311967_32630 34112799 32630 gcuagcuggaggggcgccaguucgcuggugguugggugcggucggcuagcc <<<<<<<......<<<<<<<....>>>>>........>>....>>>>>>>. (((((((.(....(((((((....)))))........))...)))))))). Crystal structure of the Chili RNA aptamer in complex with DMHBO+; Chili RNA Aptamer 7oax C 51 2.24 URS0002311967_32630 34112799 32630 gcuagcuggaggggcgccaguucgcuggugguugggugcggucggcuagcc <<<<<<<......<<<<<<<....>>>>>........>>....>>>>>>>. (((((((.(....(((((((....)))))........))...)))))))). Crystal structure of the Chili RNA aptamer in complex with DMHBO+; Chili RNA Aptamer 7oax D 51 2.24 URS0002311967_32630 34112799 32630 gcuagcuggaggggcgccaguucgcuggugguugggugcggucggcuagcc <<<<<<<......<<<<<<<....>>>>>........>>....>>>>>>>. (((((((.(....(((((((....)))))........))...)))))))). Crystal structure of the Chili RNA aptamer in complex with DMHBO+; Chili RNA Aptamer 7obr 5 3493 2.8 RF02540,RF02543 URS00023119A2_9986 34260909 0003735 0005840 9986 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccgguucaacccggcggcggguccggccgugucggcgggucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucggccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcgcucuccccccucgggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccgggggaggggccacgcggcgagcgcacggggucggcggcgacgucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcacacgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcgugagccgggcguggaauggagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagagccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagcccgcccccggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcugggucggucgucggccggcgccuagcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacauguuuuuucacugacccggugaggcgggggggcgcucgcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccggucccccgcgggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcacgccguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>>..<<<<<<<<<....<<<<<<<<.<<<....<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>>>>>>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<......>>>..................................<<<<<<<<..<<<......<<<<<<<<.....<<<<<<<<<<<...<<<....<<<<<.<....>>>.>>>......>>>.>>>>>>>>>>>..........>>>.>>>>>..<<<<<<<..<<<<<<<<<<.<<<....<...<.<<<<.<<<<......<<<<<..>>>>>.......>>>>.>>>>>.........>.>>>...>>>>>>>>>>....................<<<<<..<<<<<<<.>>>>>>>..<.<<<.<<<<..<<<<<<<<<<<<<<<<<<<<<<<.<<<<....>>>>.>>>>>>>>>>.>>>>>>>>>>>.>>....>.>>>...>>>..>......>>>>>.......>>.>>>>>....>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<<....>>>>>>>>..<<<<<...<<<..<<<...(((..[[.>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<............<<<<<<<<<...<<<....<<<..<.<<<...<<<.<.<.....>.>.>>>.>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<........>>>>>>>>>...>>...>>>>>>>.>>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<............>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<...........]].)))..............................>>>>>>>>>....>>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<<<<<...>>>>>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<...<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<<<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>.>.>>>>>>>>>>>>.........>>>>>>>..>............>>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<...<<<<<<.>>>>>>........>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>>.<<<<<.......>>>>>.........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<<<<..>>>>>>>>>>...<<<<<.....<<<<..<<...>>..............<<<<<<<<<<<.....>>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>>.<<<....>>>.>>)))......<<<<<<<..<<<..)))))).>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<]]].>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>......<<<<<<.<<..<<<.....<<.........<<<<<..<<<<..>>>>.>>>>>........>>....<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>..............>>>..>>>>>>>>.<<<<<.<.............>....<<.<<<<<<<.<<.....<<<<....<<<<<......>>>>>...>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..(((((((((((.....)))))).))))....))))....((((((.((....((((((((.(......((((((((..({((((......)))))....[[(...).(((....}]])))...).)))))))..)))))))))...)).))))))..)....(((.(((........))).))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((......((((((((.....(((((((((((...(((.(..(((((.((..))).))))..)...))).)))))))))))..........))).)))))..((((((((.((((.(((((.(((....(...(.((((.((((......(((((()))))).......)))).))))).........).)))...))))).))))....................(((((..((((((...))))))..((.((.((((..(((((((((((((((((((((((.((((....)))).)))))))))).))))))))))).))....).)))...)))..)......)))))......))).)))))....)))...)))))))).[((((........))))((((((....(((((((((((((..(((..(((((........)))).)...)))...((....))...((((((((....))))))))..(((((...(((..(((...[[[...[[)))..)))....))))).(((((((((.((((......))))))))))).))....)))))))))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((............(.((((((....(((....(((..(.(((..(.((.(.(.....)..)))).))).)..)))..)).)....))))))...(((((((((........)))))))))....)...)))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[.....(.(((((......(..........(((.((((((((.(..........).)))))))))))..........]]].)....)))))).)))...)))))))((((((.(((..........]]..]]]..............................)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...((..(.(((....))).....)....((.((((.(.((...)).).))))))......))....))...(((((........)))))]]((((....(((.....(((((((....)))))))..((((....)))...(...((((((...((((((((((((((((((((((....{{..).))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...))............))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((...((((((.))))))........)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(.(((.........)))..).......((.(......).(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.(((((((((.((((((((((..))))))))))...(((((.....((((..((.()))..............(((((((((((.....)))))))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a.))..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}..)))))..)).))...))))...)))).((((...((((.............))))...))))..)))...).))))))......(((((..(...(((.....((..........(((...((((()))))..))).........))....((..((((....((((.(((((((......)))))))))))...))))..))..............)))...).))))).(((((.(..(.......)..)....((.(((((((.((.....((((.(..(((((......)))))..)))))....))....)))).))).))..))))).. RNC-SRP early complex; 28S rRNA 7obr 7 120 2.8 RF00001 URS000002B0D5_9986 34260909 0003735 0005840 9986 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. RNC-SRP early complex; 5S ribosomal RNA 7obr 8 156 2.8 RF00002 URS00004B2C76_9986 34260909 0003735 0005840 9986 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<.<<.....>>>.....(.<<<......>>.............>>>..)...>>>....<<<..>>><<<<<<<<.......>>>>>>>>.................... .........................................((((((.[[....[)))...].(.(((......]].............)))..)...)))....((....))((((((((.......)))))))).................... RNC-SRP early complex; 5.8S ribosomal RNA 7of1 1 2787 3.1 RF02540,RF02543 URS000061F377_559292 34813592 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucggauagcagaagcucguaucaguuuuaugaguaaauauguaagaaguccuuguuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguuggaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggacgaucaacuuagaacuggacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcugucaaagugaagaaauucaaccaagcgcggguaaacggauaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaccugagcuugacucuaguuugacauugugaagagacauguuucuuuacuuauucaaugaagcggagcuggaaccacguucuagcauucaaggucccauucggggcugauccggguugaagacaugucagguggggaguuuuagucccucggaauuugaggcuagaggaaaaguuaccacaggaagcuuguggcagucaagcgacauugcuaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[...........<<.<<<<<<...>>>>>>.>>.............<<<<<<.<<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.((......<<<.....))>>>..>.>>>>>>>>>..>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<......<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<.<<<...<......>...>>>..>>.>>....>>>>>>.>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<...>>>.><<<<<<<<<<...<<<.<<<<<<<........>>>>>...<<<<.<<<........>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<....>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.....>>>>>>>>>....>>>>>><.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>.........<<<<<...>>>>>.....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>...<.{{<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..[[[..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<<....>>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>...>......>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<.....<..>......>>>>><<.<<<<<<<<<<<..>>>>>..>>>>>>.>>...........<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>........<<..<<<<.<<.....<<<<....>>>>.....>>....>>..>>>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....(((((..[[[.........((((..<<<<<.<<<<<<<<..<<<<<<.<<<..>>>.>>>>>>...<<<<<.....<<<<..<<<..>>>..........}}...<<<<<<....>>>>>>..>>>>..>>>>>....>>>>>>>>..>>>>>..[[[..((((.>>>>>>))))]]].......))))................<<<<<<........>>>>>>.....<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.......<<<<<<<....>>>.>>>>.....]]].)))))....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<....<<<<<<<<<<]]].>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<..<.......>..>.....<<<<<.<<<.<<<....<<<<....<<<<<.....>>>>>...>>>>...>>>....>>>..>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.((((((((((((.((((((((...({((((......)))))[[(...).(((....}]])))....))))))))...)))))))....)))))))))))...)....(((((((........))))))).....(((((..[[[[.[)))))..)))..................................((....))............(..((((....))))............).....................(((((.(((((......(((((((((((((((((((((((.......(((((((......((((((....)))))).......))))))).....))))).))))))))))........(((....)))....)))))))).....))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((.(((....(....)....)))..)).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((........)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((...))).).(((((((((...(((.(((((((........)))))...((((.(((........))).)))).....))))).)))))))).)...((((.((((....)))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.....)))))))))....))))))(.((((((((.((......(((..((((....)))).)))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...((((((...((.....)).))))))....[[(((.((...((....(((....)))........(.((.(...).)).)....))....))...(((((........)))))]]((((..(((.(((...((((....)))...(.<.((((((...((((.((((((((((((((((((..{{{..))))))(...((((.....(((((.....(((.....))).....)))))......))))....).(((((((....))))))).)))).).))))))).))))(...)....))))))...))....)))...))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((..)))))..)))))).))(..).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}......((..(((((((.....((((....)))).....))...)))..))))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.....((((((((..(((((.(((((((...(..(((((((..)))))).).)....((((.....((((..(((..)))...........>...((((((....))))))..))))..))))......)))))))..)))))..(((..((((.].]]]]))))))).......))))..))..)).........((((..........)))).....((((.((((((..(.(.(((((......)))))...).).(((.........))).....)))))..)...))).).....(((((((....))).)))).....))).)))))....((((((((..((((.(.((((((.....(....)....)))))).)((((....((((....((((((((((}}}.)))))..)))))...))))...)))).((((...((((.....}.......))))...)))).))))....))))))))......(((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).)))))).)(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(((((.....)))))..)))))...)))....)))).)))))).))))).. Nog1-TAP associated immature ribosomal particle population A from S. cerevisiae; 25S rRNA 7of1 2 158 3.1 RF00002 URS00001BF64E_559292 34813592 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<(.....>>............).>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Nog1-TAP associated immature ribosomal particle population A from S. cerevisiae; 5.8S rRNA 7of1 3 43 3.1 RF00001 URS000055688D_559292 34813592 0003735 0005840 559292 cugaccgaguaguguagugggugaccauacgcgaaacucaggu <<<<.......<<<<<..<<....>>.>>>>>.....>>>>.. .(((.......(((((..((....)).))))).....)))... Nog1-TAP associated immature ribosomal particle population A from S. cerevisiae; 5S rRNA 7ofw C 18 3.15 URS00023119CE_562 34653190 562 cccccccccggggggggg .................. .................. Nontypeable Haemophillus influenzae SapA in complex with heme; RNA (5'-R(P*CP*CP*CP*CP*CP*CP*CP*CP*CP*GP*GP*GP*GP*GP*GP*GP*GP*G)-3') 7ofz C 19 2.62 URS000231197D_562 34653190 562 ccccccccccggggggggg ................... ................... Nontypeable Haemophillus influenzae SapA in complex with double stranded RNA; RNA (5'-R(P*CP*CP*CP*CP*CP*CP*CP*CP*CP*CP*GP*GP*GP*GP*GP*GP*GP*GP*G)-3') 7og0 D 17 2.61 URS000231198D_562 34653190 562 cccccccccgggggggg ................. ................. Nontypeable Haemophillus influenzae SapA in open and closed conformations, in complex with double stranded RNA; RNA (5'-R(P*CP*CP*CP*CP*CP*CP*CP*CP*CP*CP*GP*GP*GP*GP*GP*GP*GP*GP*G)-3') 7og0 E 17 2.61 URS000231198D_562 34653190 562 cccccccccgggggggg ................. ................. Nontypeable Haemophillus influenzae SapA in open and closed conformations, in complex with double stranded RNA; RNA (5'-R(P*CP*CP*CP*CP*CP*CP*CP*CP*CP*CP*GP*GP*GP*GP*GP*GP*GP*GP*G)-3') 7og4 XA 1498 3.8 RF02541,RF02540 URS00021ED93A_9606 32812867 0003735 0005840 9606 gcuaaaccuagccccaaacccacuccaccuuacuaccagacaaccuuagccaaaccauuuacccaaauaaaguauaggcgauagaaauugaaaccuggcgcaauagauauaguaccgcaagggaaagaugaaaaauuauaaccaagcauaauauagcaaggacuaaccccuauaccuucugcauaaugaauuaacuagaaauaacuuugcaaggagagccaaagcuaagacccccgaaaccagacgagcuaccuaagaacagcuaaaagagcacacccgucuauguagcaaaauagugggaagauuuauagguagaggcgacaaaccuaccgagccuggugauagcugguuguccaagauagaaucuuaguucaacuuuaaauuugcccacagaacccaaauccccuuguaaauuuaacuguuaguccaaagaggaacagcucuuuggacacuaggaaaaaaccuuguagagagaguaaaaaauuuaacacccauaguaggccuaaaagcagccaccaauuaagaaagcguucaagcucaacaccaaaaaucccaaacauauaacugaacuccucacacccaauuggaccaaucuaucacccuauagaagaacuaauguuaguauaaguaacaugaaaacauucuccuccgcauaagccugcgucagauaacaacugacaauuaacagcccaauaucuacaaucaaccaacaagucauuauuacccucacugucaacccaacacaggcaugcucauaaggaaagguuaaaaaaaguaaaaggaacucggcaaaucuuaccccgccuguuuaccaaaaacaucaccucuagcaucaccaguauuagaggcaccgccugcccagugacacauguuuaacggccgcgguacccuaaccgugcaaagguagcauaaucacuuguuccuuaaauagggaccuguaugaauggcuccacgaggguucagcugucucuuacuuuuaaccagugaaauugaccugcccgugaagaggcgggcauaacacagcaagacgagaagacccuauggagcuuuaauuuauuaaugcaaacaguaaccaaaccugcauuaaaaauuucgguuggggcgaccucggagcagaacccaaccuccgagcaguacaugcuaagacuucaccagucaaagcgaaccucaauugauccaauaacuugaccaacggaacaaguuacccuagggauaacagcgcaauccuauucuagaguccauaucaacaauaggguuuacgaccucgauguuggaucaggacaucccgauggugcagccgcuauuaaagguucguuuguucaacgauuaaaguccuacgugaucugaguucagaccggaguaauccaggucgguuucuaucuacuuauuccucccuguacgaaaggacaagagaaauaaggccuacuucacaaagcgccuucccccguaaaugauaucaucucaacuuagauacccacacccacccaagaacaggguu <<<.......<<<<.....................................<......>.........<.....<<.....>>....>........>>.>>.............<<....>>......................>>>...........<<<.......>>>...<.<........>.>.<<<<<<.........<<<.<<..<<....>>...>>.>>>...<<.<..<<<<<.<.....<<<<<.<<<..<<<.....>>>...<<<..<<<<........>>>>.>>>....>>>.>>>>>...<<.......>>......>.>>>>...>..>.>>..<<<<<<....<<<<....>>>><<<.<<<<<<<<<<.....<<.......>>.....>>>>>>>>>>..>>>.<<<<<<<<<<......>>>>>>>>>>...<<<......>>>....<<<.<<<...<..............<....<<<.........>>>....>.......<<<......>>>...........................>...>>>>>>........>>>>>>...<<<<<......>>>>>.........>>>>>><......<<..<<<....>>><<<<..<<<<........<<<<<.......>>>>>......<<<...<<<<.......................>>>>.......>>>.....<<......>>.>>>>.....>>>>..<<<<...<<<<<<<<.<<.........<......<<<<<<..<<<.........>>>...<<<<<<.............>>>>>>....<<<.<<<..<<<<<....>>>..>>>>><<<<<<......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>....>>.>>>>.....>..>>.>>>>>>>>>>>>.>>.....>.....<<<<<........>>>>>.......<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<...............>>>>>>>>>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<.....<<<..<<<<.....>>>>..>>>....>>.........<<<....>>>............>>>>..>>>>>>.......<<<..<.<<<<<<...<<.......>>...>>>>>>...>.>>.>.......<<<<<.<<<<<<..<<.<<<<<<......>>>>>>...>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>.<<<.<<<.................>>>.>>><<<<<...<<<....>>>.>>>>>......<<<................>>>.............<<<<.......>>>>. ((.....(..((((.....................................(...[..).........(.....((.]...))....)........)).)).............((....))....)..................)).........(.(((.......))).[.(.(........).).((((((.........(((.((..((....))...)).)))...((.(...((((.(.....(((((.((((.(((....[)))...(((..((((.......{)))).)))..).))).))))).(.((.......))...)..).))))......).))..((((((....((((....)))).((.((((((((((.....((.......)).....))))))))))..))..((((((((((......))))))))))...(((......)))....(((.(((...(..............(....(((.........)))....)....(..(((......))))..........................)...))))))........))))))...(((((......))))).........))))))(......((..(((....)))(((...((((......(.(((((.......)))))......(((...((((...............(..)....)))).......))).)...((......)).))))......)))..((((....(((((((.((..(....(........((((((.].((.........))....((((((.............))))))....(((.(((..(((((....)))..)))))(((((........)))))........((..........(((((.......)))))..)..)....)))....)).))))....)..))).))))))).)))).)).....)).{..(((((.....]}.))))).......((..(((.((......((((.((((((..(((((.((((((((...............)))))))))))))..(((......[)))((((((..........]))))))(.((.....((...(((....[..)))...))....)).........(((....))).....)].....))))..))))))......((((..(.((((((.(.((.......)))..))))))...).)).).).....(((((.((((((..((.((((((......))))))...)).(((((.....))))).....)))))..)...))).))....(((((((....))).))))..}.))..))).)).(((.(((......(....).....))).)))(((((...(((....))).)))))......(((................))).............((((.......)))). Human mitochondrial ribosome in complex with P/E-tRNA; 16S mitochondrial rRNA 7og4 AA 924 3.8 RF00177 URS0002311A2B_9606 32812867 0003735 0005840 9606 auagguuugguccuagccuuucuauuagcucuuaguaagauuacacaugcaagcauccccguuccagugaguucacccucuaaaucgaucaaaaggaacaagcaucaagcacgcagcaaugcagcucaaaacgcuuagccuagccacacccccacgggaaacagcagugauuaaccuuuagcaauaaacgaaaguuuaacuaagcuauacuaaccccaggguuggucaauuucgugccagccaccgcggucacacgauuaacccaagucaauagaccggcguaaagaguguuuuagaucacaauaaagcuaaaacucaccugaguuguaaaaaacuccaguugacacaaaauagacuacgaaaguggcuuuaacauaucugaacacacaauagcuaagacccaaacugggauuagauaccccacuaugcuuagcccuaaaccucaacaguucaacaaaacugcucgccagaacacuacgagccacagcuuaaaacucaaaggaccuggcggugcuucauaucccucuagaggagccuguucuguaaucgauaaaccccgaucaaccucaccaccucuugcucagccuauauaccgccaucuucagcaaacccugaugaaggcuacaaaguaagcgcaaguacccacguaaagacguuaggucaagguguagcccaugagguggcaagaaaugggcuacauuuucuaccccagaaacgauagcccuuaugaauaagggucgaagguggauuuagcaguaaacuaagaguagagugcuuaguugaacagggcccugaagcgcguacacaccgcccgucacccuccucaaguauacuucaaaggacuuaacuaaaaccccuacgcauuuauauagaggagacaagucguaacaugguaaguguacuggaaagugcacuuggacgaac ..((((..<<<<<<.)))).<<<<<<.<...<<<<<<<<..<.<<<.<<<..<......>......<<........<<<.<..<<..>>.>..>>>...<<<<....<<...<<<....>>>..>>......>>>>.<<...>>.>>.<<<....>>>.....>>>>>>>........<<<....<<<......>>>..>>>..>>.>>>>>>.....<<<<<<<<.....(((.....((.>>>)).......)))..>>>>>...>.>>>>>>..<<<((.....<<<<..<<<<......<<<<<<......<<<.<<<.<<<......>>>..>>>.>>>.............<<....>>.>>>>>>.....>>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<.<<<<<..))..>>>>>.>.>>>.<<.......<<<<....>>>>.....>>..>>>>>><<<<<.<<<<<<<...<<<.<<<<<..<<<<<<<<<<.....<<........>>..........<<<<<<<.......<<.<<<..<<<<<<.<.....<<..<<<<<.....>>>.......>>..>>.....<<<....>>>.....>...>>>...>>>>>>>>....>>>>>>>..>>.>>>>>>>>.....<<<<.....>>>>.<....<<<<<<<....>>>>>>>....>.....>>>>>.....<<<<<<<.........>>>>>>>.....>>>...>>>>>>>>>>.>>....<..<<.<...<<<<<<..<<<<<..<...<<<..<<.....>>...>>>....>..>>>>>.>>>>>>....>.>>...>.....<<<<<<<<<....>>>>>>>>>........ [.[[[[..(((((..]]]]]((((((.((...(((((((....(((.(((..(......)......(((.......(((.(..((())).)..)))...((((....((..((((....))).)))......)))).((...))))).(((....))).....)))))).......(.(((...(((((....)))).))))).)).)))).).....((((([[[.....(((.....((.]]])).......)))..)))))..)).))))))..((([[...(.(((....(((......(((((((.....(((.(((.(((......)))..))).))).....).....(.((....))))))))).....))).....)))....((((((...((...((((.........))))...))))))))......{...(.(((((..]]..))))).))))).((.......((((....)))).....))...)))))((.((.(((((((...(((.(((((..((((((((((.....((........))..........(((((((.......((.(((...((((((.(....((..(((((.....))).......))..))......((....))......).).)))...)).)))))....)))))))..)).)))))))).(...((((.....)))).(....(((((((....)))))))....)..)..))))).....(((((((.........))))))).....)))...)))))))))..))..(.(..((.....((((((..(((((..((..(((..((.....))...)))..).)..))))).))))))......))...)..)..(((((((((....)))))))))}....... Human mitochondrial ribosome in complex with P/E-tRNA; 12S mitochondrial rRNA 7oh3 1 3013 3.4 RF02540,RF02543 URS000061F377_559292 34813592 0003735 0005840 559292 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.........................<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..<<<..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<.<<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.((......<<<.....))>>>..>.>>>>>>>>..>>>>>>>>...>>>>>>>>>>>........<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<......<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<...>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<......>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>.><<.<<<<......<<<.<<<<<<....<..<.........>..>....>>>>...<<<<.<<<....>>>.>>>>...>>>>>....>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<.........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<......>>>>>>>>>....>>>>>><.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<..>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>...<.{{<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..[[[..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<...>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>...>......>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<...............>>>>><<.<<<<<<<<<<<..>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>.............<<<.<<..<<<.....<<<<....>>>>.....>>>>>>>>........<<.<......>.>>..........<<..>>......>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<....>>>>>....<<<<<..<<<<......<<<<<<<<<<<..<<<<<.<<<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<<<<.....<<<<...<<<<.....>>>>...........}}...<<<<<<..>>>>>>..>>>>.>>>>>.....>>>>>>>>..>>>>>......<..<...<<<<<<..........>>>>>>.......<<<<<<<...<<<<<<.......>>>>>>.....<<......>>....>>>>>>>...<<<..<<<<.......>>>>..>>>.<<<....>>>...>.>......<<<<<...<<<<.))))))>>>>.>>>>>.........>>>>..>>>>>>>.............<<<<<<...<<.....>>...>>>>>>................<<<<...<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>....>>>>......<<<<<<<....>>>.>>>>....>..>>>.>>>>>....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<...<<<<<<<<<<<]]].>>>>>..>>>>>>..>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.....<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<..<.......>..>.....<<<<<<<<<.<<<....<<<<....<<<<<....>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))))...)))))))))))...)....(.(((((........))))).).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((...(((......((((((((((((.((((.(((((.......(((((((......((((((...)))))).......))))))).....)))))..)))).))))........(((....)))....)))))))).....)))...)))))..((((........))))((((((....((((((.((((((..(.(...(((.......)))...).)...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)<)))...(((..((.((........)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(....(....(((.(((((((.......................)))))...((((..((....))..))))...)))))...)....).))..((((.((.((.....).))).))))....(((......)))...(((((((...((([[[...(.(((((.......(..........((.((((((((((.....{.(((((.(.(...((.........))...).).....(...((......)).).)))))...))))))))))))...........]]].).....)))))))))...)))))))(((((((((......)))))))))....))))))(.((((((((.((......(((..((((....)))).)))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........((((..))))....))....))...(((((........)))))]]((((..(((((((...((((....)))...(.[.((((((...((((.((((((((((((((((((..{{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....).((((((...)))))).)))).).))))))).))))(...)....))))))...))....))))..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((..)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).]...........((((.(...((.....((((....)))).....)).)))))........((.(......).))...........(..).......)).))))))).)..))).)))))))..))))))....)).[..(((((..].)))))....(((((..((((......(((((((((((..(((((.(((.((((..(((((((((.....)))))))))....((((.....((((...(((.......)))............]...((((((..))))))..)))).))))......)))).)))..)))))......(.(.....(((((..........)))))........(((((((...((((((.......))))))...................)))))))...(((..(.(.........).)..)))((((....))).).).)...(..(((.(...((((.]]]]]])))).).)))....)....))))..))))))).............((((((...((.....))...))))))................((((..(((((..(.(((((((......))))))..).).(.(.(.....).).).....)))))...)))).......((.(((....)))..)).....)..))).))))).....(((((((..((((.(.(((((......(....).....))))).)((((....((((....((((((((((}}}.)))))..)))))...))))...)))).((((...((((.....}.......))))...)))).))))....))))))).....(((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).)))))).)(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..))))))..)))))...)))....)))).)))))).))))).. Nog1-TAP associated immature ribosomal particle population B from S. cerevisiae; 25S rRNA 7oh3 2 155 3.4 RF00002 URS00001BF64E_559292 34813592 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuuggauccagggggcaugccuguuugagcgucauu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<..>>>>>>>>>.................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((..))))))))).................... Nog1-TAP associated immature ribosomal particle population B from S. cerevisiae; 5.8S rRNA 7ohp 1 1567 3.9 RF02540,RF02543 URS000061F377_559292 34813592 0003735 0005840 559292 guuugaccucaaaucagguaggaguacccgcugaacucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacgcgagugaagcggcaaaagcucaaauuugaaaucugguaccucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuuaugcagcucuaagugggugguuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaguacagugauggaaagaugaaaagaacuuugagagagugaaaaaguacgugaaauuguugaaaggaagggcauuugaucagacaugguguuuuguucucgcauuucacugggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcaaaugguuauaugccgccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaacgagguuggggccucgaagaggugcacaaucgaccgauccugaggauggauuugguaagagcauagcuguugggacccgaaagauggugaaaccaucuaguacugguuccugccgaaguuucccucaggauagcagaagcucguucaguuuuauguaagaaugaagcuuuuagugggccauuuuugggcagaacuggcgaugcgggaugccgaacguagaguuaaggugccggaauacacgcucaagacaaaagguguuaguucaucuagacagccggacggugccauggaagucggaaccgcaggaguguguaacaacucaccggccgaaugaacuagcccugggcgcucaagcguguuaccuauacucuaccgucaggguugauaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcagcgaaaccacagccaaggcgggaaucagcauaccgaagcagaauucgguaagaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuugcggcugucugaucaggcagccgcgaagcuacauccgcuggauuauggcugaacccucuaagucagauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguacugcugagauuaccuuuguugucugauuugu ..........................<<<<<<..........>>>>>.>.........<<....>>...<<<<......<<....>>.....>>>>...<<<...........<<.<<<<<<..>>>>>>.>>.............<<<<<<<.<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.((......<<<.....))>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<....>>>>>>>.....<<<<<<..>>>>>>..>>>.................................<<....>>...............<<<...>>>.................................<<<<.<<<<<<..............<......>..........<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<........>>>.......>>>>>>>>..>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>.>>>>>.<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...........<<<<<..<<<<<...>>>>>...>>>>>.<<<..<<<.......>>>...>>>....>>>>>>.>>>>>>..<<.<..<<<<<<<...>>>>>>>....>.>>..<<<<<<......<.......>...<<<<<<<<<...<<<.<<.........>>>>>>>>>>>>.>>..<<<<....<<..>>....>>>>....<<<....>>>...<<<<<<<..<<<<(((.....<<<<<<...<<.....<<<.<<<<<<<<<........<<<<<.<<<..<<.........>>..>>>.......<<......>>...>>>>>....>>>>>>>>>>>>.))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<......>>>>>>>>>....>>>>>><..<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>...>.....>>>>>><<..............>>...............<<<.....<<<<<<......>>>>>>..>>>....<.<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<....<<<<<<<<........>>>>>>>>.....>>.>>>>>.<<<<...<<<<<..........>>>>>..>>>>.>>>>....>>>>>>.>......<<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>.><<<<<.....................<<<<<.<<<.<<<....<<......>>...>>>..>>>..>>>>>..>>>>>.. ..........................(((((............)))).).........((....))....(((......((....)).....)))....((((.........(((.((((((..)))))).))....)........(((((((.(((((((((((.((((((((...({((((......)))))[[(...).(((....}]])))....))))))))...)))))))....)))))))))))...)....(.(((((....))))).).....((((((..))))))..))).................................((....))............(..(((...)))............)....................(((..(((((((.............(......)...........((((((((((((((((((((((.......(((((((......(((........))).......))))))).....))))).))))))))))........(((....)))....)))))))....)))))).).))).(((..........)))((((((..(.((.(((.((((((..(((...(((.......)))...)))...........(..((...((((...))))....))..)..((...((.......))....)).....)))))).)).)))..((.(...((((((...)))))).....).))).((((((........(.....)...((((..((.....((.((.........))))..))..)).))..((((....(....)....))))....(((....)))...(((((((...((([[[...(.(((((.....(......((.((.(((((((........((((.(.(...(.........)...).)...(...((......)).).))))....))))))).))))..]]].).....)))))))))...)))))))((((((((........))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....(...)....))....(.......)..(.(.....((((((......))))))..).)....((.(((((..((((.(.(((((......(....).....))))).)(((((...(.(...((((((((((....))))))))))....).).))))).((((...((((............))))..)))).))))....))))).)).......((((((.(((.((....((.(........((((((.....)))))).....))).......((((((...((.((.(..(((......)))..).)).)).)))))).............)).))).))))))..(((((....(.......)......(.(((((.(((.(......(..(..)..).....)..)).).)))))).))))).. Nog1-TAP associated immature ribosomal particles from S. cerevisiae after rpL25 expression shut down, population A; 25S rRNA 7ohp 2 149 3.9 RF00002 URS00001BF64E_559292 34813592 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcaccgccccuugccagggggcaugccuguuugagcgucauuu .........................................<<<<<<<<<....>>>>.....<.<<<......>>..............>>>..>...>>>....<...><<<<.<<<.>>>.>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....(...)((((..((.))..))))..................... Nog1-TAP associated immature ribosomal particles from S. cerevisiae after rpL25 expression shut down, population A; 5.8S rRNA 7ohp 6 65 3.9 URS000013305B_559292 34813592 559292 ccuucucaaacauucuguuugguagugagugauacucuuuggaguuaacuugaaauugccuuaaa ......<<<<<.....>>>>>.....<<<<.<.<<<<....>>>>>.>>>>.............. .......((((.....))))......((.(...((((....))))..).)).............. Nog1-TAP associated immature ribosomal particles from S. cerevisiae after rpL25 expression shut down, population A; ITS2 7ohq 1 3053 3.1 RF02540,RF02543 URS000061F377_559292 34813592 0003735 0005840 559292 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..........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.((((((((((((.((((((((...({((((......)))))[[(...).(((....}]])))....))))))))...)))))).)...)))))))))))...)....(.(((((........))))).).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.(((((......(((((((((((((((((.(((((.......(((((((......((((((....)))))).......))))))).....)))))..)))))))))........(((....)))....)))))))).....))))).)))))..((((........))))((((((....((((((.((((((..(.(...(((.......)))...).)...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)<)))...(((..((.((........)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((...........(((.((((((.........................))))...((((.((((..)))).)))).....)))))..........))..((((.(..((.....))..).))))....(((......)))...(((((((...((([[[...(.(((((.......(...........((.((((((((((.....{.(((((.(.(...((.........))...).).....(...((......)).).)))))...))))))))))))...........]]].).....)))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((.(.((......(((..((((....)))).)))...))).))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...((((((...((.....)).))))))....[[(((.((...((....(((....)))........((((((........))))))....))....))...(((((........)))))]]((((..(((((((...((((....)))...(.[.((((((...((((.((((((((((((((((((..{{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....).((((((......)))))).)))).).))))))).))))(...)....))))))...))....))))..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((..)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].............(((.(...((.....((((....)))).....)).))))..........(...............)...........(..).......)).))))))).)..))).)))))))..))))))....)).[..(((((..].)))))....(((((..(((.(......(((((.((((((..((((..(((.((((..(((((((((.....)))))))))....((((.....((((...((((.....).)))............]...((((((....))))))..))))..))))......)))).)))...))))......(.(.....(((((...........)))))........(((((((...((((((.......)))))).....((......))....)))))))...(((..(.(.........).)..)))((((....))).).).)........((.(...((((.]]]]]])))).).))...........))))..))))))).............((((((...((.......))...)))))).................((((.((((((..(.(((((((......))))))..).).(.(.(.....).).).....))))))...))))......(((.(((....)))..))).....)..))).))))).....(((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}}.)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))..(((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...((.((.(..(((......)))..).)).)).)))))).............)).))).)))))).)(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Nog1-TAP associated immature ribosomal particle population C from S. cerevisiae; 25S rRNA 7ohq 2 158 3.1 RF00002 URS00001BF64E_559292 34813592 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<(.....>>............).>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Nog1-TAP associated immature ribosomal particle population C from S. cerevisiae; 5.8S rRNA 7ohq 6 65 3.1 URS000013305B_559292 34813592 559292 ccuucucaaacauucuguuugguagugagugauacucuuuggaguuaacuugaaauugccuuaaa ......<<<<<<...>>>>>>.....<<<<...<<<<....>>>>..>>>>.............. .......((((.....)))).....(((((...((((....))))..))))..)........... Nog1-TAP associated immature ribosomal particle population C from S. cerevisiae; ITS2 7ohr 1 2373 4.72 RF02540,RF02543 URS000061F377_559292 34813592 0003735 0005840 559292 guuugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaacgagguuggggccucgcaagaggugcacaaucgaccgauccugaggauggauuugguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggagcucgguucgacguucgaucgugaauuggguauagggcgaaagacaaccaucuaguagcugguuccugccgaaguuucccuaggauagcagaagcucguaucaguuuuaugaguaagaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcacugcuggcuccggugcgcuugugacggccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggacccuguugagcuugacucuaguuugacauuauugucagguggggaguaaaguuaccacagggauaauggcuuguggcagucaagcguucagcgacauugcucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacguggcuggguagaccgucgugagacgguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcaugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuugguuacgaucugcugagauuaagccuuuguugucugauuugu 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..........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........(((((((.((((((((((((((((((.(...({((((......)))))[[(...).(((....}]])))....).))))))..))))))))....)))))))))))...)....(.(((((........))))).)......(((((..)))))...)))..................................((....))............(..((((....))))............).....................(((((.(.(((......((((((((((((((.((((((((.......(((((((......(((((......))))).......))))))).....))))).))).))))))........(((....)))....)))))))).....))).).)))))..((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...........(((((..(((((....)))))...))))).((((..((.......))...))))....)))))).))))))..((.(...((((((...(.((((((.....((((...(((((((....)))))))...)))).(...((...))...).......)))))).).((....).).))))))......).))).((((((........(....)...(((((.((.....(((.((((((..)))).)))))...)).))).))..((((..(.((.....)).)..))))....(((......)))...(((((((...((([[[...(.(((((.......(........((.((((((((.......{.(((((.(.(...((.........))...).).....(...((......)).).))))).....))))))))))...........]]].).....)))))))))...)))))))((((((((...........))))))))....))))))(.(.((((((.((......(((..((((....)))).)))...)))))))).)..).....))))))((.....((.....((((((.......))))))((((.....(((((.((...((((((...((.....)).))))))....[[(((.((...((....(((....)))........((((((........))))))....))....))...(((((........)))))]]((((.((((((.....((((....)))...(...((((((...((((.((((((((((((((((((...[[..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....).((((((...)))))).)))).).))))))).))))........))))))...)).......)).)))))))).)))..))...))))).((((.....))))..))))..((((.....(((((((.((..(....()..))).)))))))..))))))....)).[..(((((......].)))))....(((.(..(.(.(((((.(..((((..((((.((((((((....))))))))..))))..))))....))))))............(.((...................)).)((.(..(((((..(.(((((((......))))))..).).(.(.........).).....))))).....).)).....((.(((....))).)).........).).).))).....(((((((..((((.(.(((((......(....).....))))).)(((((...(.((....((((((.(((]]..))).).)))))...)).)..))))).((((...((((.....}.......))))...)))).))))....)))))))..(.....((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...((.((.(..(((......)))..).)).)).)))))).............)).))).))))))).(((((.(..(.......)..)...(.((((((.((.(((....((((....(...((..))...)...))))...)))....)).).)))))).))))).. Nog1-TAP associated immature ribosomal particle population E from S. cerevisiae; 25S rRNA 7ohr 2 158 4.72 RF00002 URS00001BF64E_559292 34813592 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<<...>>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Nog1-TAP associated immature ribosomal particle population E from S. cerevisiae; 5.8S rRNA 7ohr 6 65 4.72 URS000013305B_559292 34813592 559292 ccuucucaaacauucuguuugguagugagugauacucuuuggaguuaacuugaaauugccuuaaa ......<<<<<<...>>>>>>.....<<<<...<<<<....>>>>..>>>>.............. .......(((((...))))).....(((((...((((....))))..))))..)........... Nog1-TAP associated immature ribosomal particle population E from S. cerevisiae; ITS2 7ohs 1 1697 4.38 RF02540,RF02543 URS000061F377_559292 34813592 0003735 0005840 559292 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Nog1-TAP associated immature ribosomal particle population F from S. cerevisiae; 25S rRNA 7ohs 2 147 4.38 RF00002 URS00001BF64E_559292 34813592 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacgccccuugcagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<(.....>>............).>>>..)...>>>........<<<<<<....>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....(..)(((((......)))))..................... Nog1-TAP associated immature ribosomal particle population F from S. cerevisiae; 5.8S rRNA 7ohs 6 65 4.38 URS000013305B_559292 34813592 559292 ccuucucaaacauucuguuugguagugagugauacucuuuggaguuaacuugaaauugccuuaaa ......<<<<<<...>>>>>>.....<<<<...<<<<....>>>>..>>>>.............. .......(((((...))))).....(((((....(((....)))...))))..)........... Nog1-TAP associated immature ribosomal particle population F from S. cerevisiae; ITS2 7oht 1 1485 4.7 RF02540,RF02543 URS000061F377_559292 34813592 0003735 0005840 559292 cuauuggaacaggacgucauagagggugagaaucccgugugggaccgauaguaagaacugagagugaaaaaguacgugaaauuguugacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccugguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauugcgaguguuuggguguaaacccauacgcgaacguaggguccugggauaagagcauaguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaacuuuaaauauguaagaaguccuuguuugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacacacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaaggauggcgcucaagcguguuaccuauacucuaccgucaggguuaugcccugacgaguaggcaggcguggaggucagugagaagccugacaaggucgggucgaacggccucuagugaaucagcgggggaagacccuguugagcuugacucuagguggggaguuugggggcggcacaucuguuaaacgauaagcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuauagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguuagcgacauugcuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggagucuggguuuagaccgucgugagacagguuaguuccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcaugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccguuacgaucugcugagauuaagccuuuguugucugauuugu <..............((......<<<.....))>>>....>................<...>.............................<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<...>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>..<<<........<<<<....>>>>................<<<..>>>.....>>>.....<<<<<<....<.<<<....>>>.><<.<<.<......<<<.<<<<<<.......................>>>>...<<<<..<<<..>>>..>>>>.....>>>>>.....>.>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<.........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>.........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<...>>>>>>>>>....>>>>>>...<<<<<<..<<.....<<<<<<.....>>>>>>...>>.>>>>>>.....<<<<<..<<......<<<<<.<<.<<<..<<<<<......>>>>>......<.<..<<.<<<<<..........>>>>>.>>.....<<<<<<<...<<<.<.........>.>>>.................>>>>>>>...<<<..<<<<.......>>>>..>>>.<<<....>>>...>.>........<.....>............>>>...>>>>>>>..............<<<<<...<<....>>...>>>>>.................<<<...<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>>>......<<<<<<<....>>>.>>>>.....>>.>>>>>....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<...<<<<<<<<<<<....>>>>>.>>>>>>..>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<.<..<<<<<.>>>>>..>>>>>...>>>....>>>>.>>>>>..>>>>>.. 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Nog1-TAP associated immature ribosomal particles from S. cerevisiae after rpL2 expression shut down, population A; 25S rRNA 7oht 2 19 4.7 RF00002 URS00001BF64E_559292 34813592 0003735 0005840 559292 aacaacggaucuugguucu ................... ................... Nog1-TAP associated immature ribosomal particles from S. cerevisiae after rpL2 expression shut down, population A; 5.8S rRNA 7ohu 1 1692 3.7 RF02540,RF02543 URS000061F377_559292 34813592 0003735 0005840 559292 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Nog1-TAP associated immature ribosomal particles from S. cerevisiae after rpL2 expression shut down, population B; 25S rRNA 7ohu 2 148 3.7 RF00002 URS00001BF64E_559292 34813592 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacgcgccccuugccagggggcaugccuguuugagcgucau .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<..>><<<<<<.....>>>>>>................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((..))(((((..()...)))))................... Nog1-TAP associated immature ribosomal particles from S. cerevisiae after rpL2 expression shut down, population B; 5.8S rRNA 7ohv 1 2141 3.9 RF02540,RF02543 URS000061F377_559292 34813592 0003735 0005840 559292 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...........................<<<<<.....<<....>>......>>>>>...........<<....>>..<<<<<......<<.....>>.....>>>>>..<<<..<........<<.<<<<<<...>>>>>>.>>........>....<<<<<<<.<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.((......<<<.....))>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....<<<<<<..>>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<......<<<<<<<.<<<<<<<<<<<<<<<......<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>...>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<.......>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<....<<<<..>>>>..>>>>>>>.....>.>>..<<<<<<....<.<.......>.><<<<<<<<<....<<<.<<<<<..>>>>>>>>..>>>>>>>.>>..<<<<.<<<<.......>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<.....<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>.......))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><..<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>...>.....>>>>>><<.....<<.<<<<<<.......>>>>>><<<<<..<<<...<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<......<<<....>>>...<...<<<<<<...<<<<.<<<<<<<<<<<<<<<<<<.......>>>>>><...<<<<<....<<<<<<..<<.....>>....>>>>>>.....>>>>>....><<<<<<<...>>>>>>>>>>>.>>>>>>>>.>>>>.......>>>>>>...>........>>.>>>>>>>>>>>>..>>..>>>.<<<<....>>>>.>>>>>..<<<<.....<<<.>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<<<<<..<<<<<<<....>>>>>>>..>>>>>........<<<<...<<..>>...>>>>....<.<<<<<<<......>>>>>>>...>........>>.>>>>>....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<....<<<<<<<<<<....>>>>>.>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<.....>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ..........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........(((((((.((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))))....)))))))))))...)....(.(((((........))))).).....((((((..))))))..)))..................................((....))............(..((((....))))............).....................(((((.(((((......(((((((((((((((((((((((.......(((((((......(((((((..))))))).......))))))).....))))).))))))))))........(((....)))....)))))))).....))))).)))))..((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).(((.(.((.......))..).).))....)))))).))))))..((.(...((((((....((((()))))..))))))......).))).((((((........(....)...(((((.((......((.(((((())))))))....)).))).))..((((.((.((.....)).)).))))....(((......)))...(((((((...((([[[...(.(((((.......(......((.((((((((((.....{.(((((.(.(...((.........))...).).....(...((......)).).)))))...))))))))))))........]]].).....)))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.((((((.......))))))((((...((((..((...((((((...((.....)).))))))....[[(((.((...((....(((....)))..((((((........))))))....))....))...(((((........)))))]]((((.(((((((....((((....)))...(...((((((...(.((.(((.((((((((((((((....[..))))))(...((((.....(((((...((.....)).....)))))......))))....)(((((((...))))))))))).)))).))).)).)(.)....))))))...)).....).)).)))))))).)))..)).)))).(((......)))..))))..((((.....(((.)))..))))))....)).[..(((((......].)))))....(((.(..(((((((..(((((((....)))))))..)))))........((.....((..)).....))....(.((((((........)))))..).).......))..).)))....((((((((..((((.(.(((((......(....).....))))).)(((((...(((.....(((((((.((]...)).)).)))))....)))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.((.((((((.(((....((((.(..((.((.)..).))..)))))...)))....)))).)).))).))))).. Nog1-TAP associated immature ribosomal particles from S. cerevisiae after rpL2 expression shut down, population C; 25S rRNA 7ohv 2 155 3.9 RF00002 URS00001BF64E_559292 34813592 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacgcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<..>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((..))(((((((((....)))))))))..................... Nog1-TAP associated immature ribosomal particles from S. cerevisiae after rpL2 expression shut down, population C; 5.8S rRNA 7ohv 6 65 3.9 URS000013305B_559292 34813592 559292 ccuucucaaacauucuguuugguagugagugauacucuuuggaguuaacuugaaauugccuuaaa ......<<<<<<...>>>>>>.....<<<<.<.<<<<....>>>>>.>>>>.............. .......((((.....)))).....(((((...((((....))))..))))..)........... Nog1-TAP associated immature ribosomal particles from S. cerevisiae after rpL2 expression shut down, population C; ITS2 7ohw 1 1639 3.5 RF02540,RF02543 URS000061F377_559292 34813592 0003735 0005840 559292 guuugaccucaaaucagguaggaguacccgcugaacuuauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacgcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaugguguuuugugcccucugcuccuuguggguaggggaaucucgcauuucacugggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaacgagguuggggccucgcaagaggugcacaaucgaccgauccugaggauggauuugguaagagcauagcuguugggacccgaaagauggugaaaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugaaaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcagcgaaaccacagccaaggaacgguugggcuugggcagucaagcgcgacauugcuauaccgaagcagaauucgguaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucuaucaggcauugccgcgaagcuacauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugaugcuccacacagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcagcugcugagauuccuuuguugucugauuug 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..........................(((((......(()).......)))).).........((....))...((((......((....)).....))))...((((.........(((.((((((...)))))).))....)........(((((((.(((((((((((.((((.(((...({((((......)))))[[(...).(((....}]])))....))).))))...)))))))....)))))))))))...)....(.(((((........))))).).....((((((..))))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((......(((...((((.((((((((((..).))))))))).....))))...)))...(((((((((((((((((((((((.......(((((((......(((((......))))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).)))))..((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...........(((((..(((((....)))))...)))))..(((..((.......))...))).....)))))).))))))..((.(...((((((....))))))......).))..((((((......(........)..(((((.((......((.(((.....)))))....)).))).))..((((.((.((.....)).)).))))....(((......)))...(((((((...((([[[...(.(((((.......(........((.((((((((((.....{.(((((.(.(...((.........))...).).....(...((......)).).)))))...)))))))))))).......]]].).....)))))))))...)))))))((((((((...........))))))))....))))))(.((((((.(.((......((((.((((....))))))))...))).))))))..).....))))))((.....((.))....)).[..(((.......].))).....((((((...(())...))))))..((((((......))))))....(.(((((..((((.(.(((((......(....).....))))).)(((((...(.(.(...(((((((.((...)).))..))))))...).).))))).((((...((((.....}.......))))...)))).))))....))))).)..((((((......((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).))))))............)))))).((((((....(.......)......(.(((((((((.(((....((.().))...))).)))).)))))).)))))) Nog1-TAP associated immature ribosomal particles from S. cerevisiae after rpL25 expression shut down, population B; 25S rRNA 7ohw 2 149 3.5 RF00002 URS00001BF64E_559292 34813592 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacgcgccccuugcagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<..>><<<<<<<..>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((..))(((((.(()).)))))..................... Nog1-TAP associated immature ribosomal particles from S. cerevisiae after rpL25 expression shut down, population B; 5.8S rRNA 7ohw 6 65 3.5 URS000013305B_559292 34813592 559292 ccuucucaaacauucuguuugguagugagugauacucuuuggaguuaacuugaaauugccuuaaa ......<<<<<<...>>>>>>.....<<<<.<.<<<<....>>>>>.>>>>.............. .......((((.....)))).....(((((...((((....))))..))))..)........... Nog1-TAP associated immature ribosomal particles from S. cerevisiae after rpL25 expression shut down, population B; ITS2 7ohx 1 1561 3.3 RF02540,RF02543 URS000061F377_559292 34813592 0003735 0005840 559292 guuugaccucaaaucagguaggaguacccgcugaauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacgcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuuggaugcagcucuaagugggugguuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaaggaagggcauuugaucagacaugguguuuugugcccucugcuccuuguggguaggggaucucgcauuucacugggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaauugaacguagguuggggccucgcaagaggugcacaaucgaccgauccuggauggauuugguaagagcauagcuguugggacccgaaagauggugaaaaccaucuaguacugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuauguaagaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaagaacaaaauaguucaucuagaccggguggccauggaagucggaauccgcuaaggaguguguaacaaccggaugaacuagcccugggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcagcgaaaccacaccaaggggcuuggcuaccgaagcagaaguaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucucaggcagccgcgaagcuaccauccgcuggauuauggcugaacccucuaagucagauccaugcuagaagcggugaugcuccacacagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcgcugagauuaagccuuuguugucugauuugu ..........................<<<<<<...........>>>>>.>.........<<....>>..<<<<<......<<....>>.....>>>>>..<<<...........<<.<<<<<<...>>>>>>.>>.............<<<<<<<<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.((......<<<.....))>>>..>.>>>>>>>>>..>>>>>>>....>>>>>>>>>>>........<<<<<<<......>>>>>>>.....<<<<<<..>>>>>>..>>>.................................<<....>>...............<<<......>>>.................................<<<<<.<<<<<<.....<<<<...<<<..<<<<<<<<<.....>>>>>>>>>.....>>>...>>>>..<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<....>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>.............<<<<<..<<<<<....>>>>>...>>>>>.<<<...<<.....>>....>>>....>>>>>>.>>>>>>..<<.<...<<<<<<....>>>>>>.....>.>>..<<<<<<......<<......>>..<<<<<<<<<....<<<.<<<<<..>>>.>>>>>..>>>>>>>.>>..<<<<.<.<<<.....>>>>..>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<....<.......<<<<<<<<......<<.....<<.........>>...............<<......>>>>.>>>>>>>>......))).>....>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.>>....>>...<<<<<...>>>>>.<<<..........>>>..<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<....<<<<<...........>>>>>...>>>>..>>>>>.<<<<...<<<<<..........>>>>>..>>>>.>>>>...>>>>>>>>.<<<<<<......<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>............>>>>>>.<<<<<<<<.............>.....<<<<<<<<<.<<<....<..>...>>>....>>>.>>>>>>.>>>>>>>. ..........................(((((.............)))).).........((....))...((((......((....)).....))))...((((.........(((.((((((...)))))).))....)........((((((((((((((((((.((((((((...({((((......)))))[[(...).(((....}]])))....))))))))...)))))))....)))))))))))...)....(.(((((......))))).).....(((((....)))))..))).................................((....))............(..((.(....).))............)....................(((((.((((((......(((...((((.((((((((((..).)))))))))....))))...)))...(((((((((((((((((((((((.......(((((((......((.((....)).)).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).)))))..((((........))))((((((..(.((((((.((((((..(((...(((.......)))...))).............(((((..(((((....)))))...))))).((.....(.....)......))....)))))).))))))..((.(...((((((....)))))).....).))).((((((..................(((((.((.....(((.((((....)).)))))...)).))).))..((((..(.((.....)).)..))))....(((......)))...(((((((...((([[[...(.(((((.....(........(((((((......((.(...((.........))...)...........((......)))).))))))).......]]].).....)))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.))....)).[.(((((..])))))..((..........))....(((((((..((((...(((((......(....).....)))))..(((((...(((.....(((((...((.).)..)))))....)))..))))).((((...((((............))))..)))).))))...)))))))..((((.(......((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).))))))............).)))).(((.((.(..(.......)..)...(.(((((((((.((.....(())....))....)))).)))))).)).))). Nog1-TAP associated immature ribosomal particles from S. cerevisiae after rpL34 expression shut down, population A; 25S rRNA 7ohx 2 148 3.3 RF00002 URS00001BF64E_559292 34813592 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacgcgccccuugccagggggcaugccuguuugaggucauu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<..>><<<<..<<.>>..>>>>................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...))).....(..).(((...((.))...)))................... Nog1-TAP associated immature ribosomal particles from S. cerevisiae after rpL34 expression shut down, population A; 5.8S rRNA 7ohy 1 1689 3.9 RF02540,RF02543 URS000061F377_559292 34813592 0003735 0005840 559292 guuugaccucaaaucagguaggaguacccgcugaacuuaauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaugguguuuugugcccucugcuuaggggaaucucgcauuucacugggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaauggugaacguagguuggggccucgcaagaggugcacaaucgaccgauccuggauggauuugguaagagcauagcuguugggacccgaaagauggugaaaaccaucuaguacugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuauuaagaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagaccaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccuguggcgcucaagcguguuaccuauacucuaccgucaggguugauugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcagcgaaaccacagccaagggacgggcuuggcagaaucagcgggcagucgcgacauugcuauaccgaagcagaauucgguaacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcagccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaaccuuuguugucugauuugu 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..........................((((((................))))).).........((....))...((((......((.....)).....))))...((((.........(((.((((((...)))))).))....)........((.((((((.(.(.(((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))).)......))))))).))...)....(.(((((........))))).).....((((((..))))))..)))..................................((....))............(..((((....))))............).....................(((((.(((((......((((...((((..((........))......))))...))))..(((((((((((((((((((((((.......(((((((......((((........)))).......))))))).....))))).))))))))))........(((....)))....)))))))).....))))).)))))..((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...((.)).......(((((..(((((....)))))...)))))...(..(((.....)))...)......)))))).))))))..((.(...((((((....)))))).....).))).((((((......(.(.....))..(((((.((......((.((((...)).))))....)).))).))..((((..(.((.....)).)..))))....(((......)))...(((((((...((([[[.....(((((.......(.......((.((.(((((((.....{.(((((.(.(...((.........))...).).....(...((......)).).)))))...))))))).))))...]]].).....))))).)))...)))))))(((((((((........)))))))))....))))))(.((((((((.((......(((..((((....)))).)))...))))))))))..).....))))))((.....((.))....)).[..(((((.....].)))))....(.(.(..(((((........)))))..((((((......)))))).......).).).....(((((((..((((.(.(((((......(....).....))))).)(((((...(.......((((((...(....)...))))))......)..))))).((((...((((.....}.......))))...)))).))))....)))))))........((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((....(.((.(..(((......)))..).)).)..)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((..(.......((.(..(...((..)..)...)..)))......)....)))).)))))).))))).. Nog1-TAP associated immature ribosomal particles from S. cerevisiae after rpL34 expression shut down, population B; 25S rRNA 7ohy 2 148 3.9 RF00002 URS00001BF64E_559292 34813592 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacgcgccccuuuccagggggcaugccuguuugagcgucau .........................................<<<<<<<<<....>>>>.....<.<<<......>>..............>>>..>...>>>....<<..>><<<<<<....>>>.>>>................... .........................................((((((.[[.....))).....(..(((.....]]............).))...)...)))....((..))(((...(...)...)))................... Nog1-TAP associated immature ribosomal particles from S. cerevisiae after rpL34 expression shut down, population B; 5.8S rRNA 7oi8 A 1092 3.5 RF02541,RF02540 URS000080E357_9606 34315873 0003735 0005840 9606 gcuaaaccuagccccaaacccacuccaccuuacuaccaaaccuuagccaaaccauuuacauaaaguauaggcgauagaaauugggcgcaauagauauaguaccgcaagggaaagaugaaaaauaccaagcauaauauagcaaggacuaaccccuauaccuucugaugaauuaacuagaaauaacuuugcaaggagagccaaagcuaagacccccgaaaccagacgagcuaccuaagaacagauuuauagguagaggcgacaaaccuaccgagccuggugauagcugguuguccaagauagaaucuuaguucaacuuuaaauuugcccacagaaccaaauccccuuguaaauuuaacuguuaguccaaagaggaacagcucuuuggacacuaggaaaaaaccuuguagagagaguaaaaaauuuaacacccauaguaggccuaaaagcagccaccaauuaagaaagcguucaagcucaacaccucccaaacauauaacugaacuccucacacccaauuggaccaaucuaucacccuauagaagaacuaauguuaguauaaguaacaugaaaacauucuccuccgcauaagccugcgucagaucacugacaauuaacagcccaauaucuacaaucaaccaacaagucauuauuacccucacugucaacccaacaggcaugcucauaaggaaagguuaaaaaaaguaaaaggaaacaucaccucuagcaucaccaguauuagaggccagcugucucuuacuuuuaaccagugaaauugaccugcccgugaggcgggcauaacacagcaagacgagacccuauggagcuuuaauuuauuaaugcaaacaccugcauuaaaaauuucgguuggggcgaccucggagcagaacccaaccuccgagcaguacaugcuaagacuucaccagucaaagcgaaccucaauugauccaauaacuugaccaacggaacaaguuacccuaggguaucuacuuuauuccucccuguacgaaaggacaagagaaauaaggccuacuucacaaagcgccuucuaaaugauaucaucucaacuuaauacccacacccaagaacaggguu <<<.......<<<<..................................<......>.....<.....<<.....>>....>..>>.>>.............<<....>>..................>>>...........<<<.......>>>...<.<....>.>.<<<<<<.........<<<.<<..<<....>>...>>.>>>...<<.<...<<<<.<.....<<<<<.<<<....>>>.>>>>>...<<.......>>......>.>>>>......>.>>..<<<<<<....<<<<....>>>><<<.<<<<<<<<<<.....<<......>>.....>>>>>>>>>>..>>>.<<<<<<<<<<......>>>>>>>>>>...<<<......>>>....<<<.<<<...<..............<....<<<.........>>>....>.......<<<......>>>......................>...>>>>>>........>>>>>>...<<<<<......>>>>>.........>>>>>><......<<..<<<....>>><<<<..<<<<........<<<<<....>>>>>......<<<...<<<<.......................>>>>.......>>>.....<<....>>.>>>>.....>>>>..<<<<...<<<<<<<<.<<.........<<<<<<.............>>>>>>........>>.>>>>>>>>>>>>.>>.....>.....<<<<<.....>>>>>.......<<..<<<.....<<<<<.<<<<<<..<<<<<.<<<<<<<<......>>>>>>>>>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<.....<<<..<<<<.....>>>>..>>>....>>.........<<<....>>>............>>>>..>>>>>>>..>>>.>>..<<<.<<<.................>>>.>>><<<<<...<<<....>>>.>>>>>.<<<.<............>.>>>........<<<<.......>>>>. ((.....(..((((..................................(...[..).....(.....((.]...))....)..)).)).............((....))....)..............)).........(.(((.......))).{.(.(....).).((((((.........(((.((..((....))...)).)))...((.(...((((.(.....(((((.((((.).))).))))).(.((.......))...)..).))))......).))..((((((....((((....))))(((.((((((((((.....((......)).....))))))))))..))).((((((((((......))))))))))...(((......)))....(((.(((...(..............(.(..(((.........)))..).)....(..(((......)))).....................)...))))))........))))))...(((((......))))).........))))))(......((..(((....)))(((...((((......(.(((((....)))))......(((...((((...............(..)....)))).......))).)...((....)).))))......)))..((((....(((((((.((..(......((((((.............)))))).......))).))))))).)))).)).....)).[..(((((..}].))))).......((..(((.....(((((.((((((..(((((.((((((((......)))))))))))))..(((......[)))((((((..........]))))))(.((.....((...(((....[..)))...))....)).........(((....))).....)].....))))..)))))))..))).))..(((.(((......(....).....))).)))(((((...(((....))).))))).(((................)))........((((.......)))). Cryo-EM structure of late human 39S mitoribosome assembly intermediates, state 3A; 16S rRNA 7oia A 1092 3.2 RF02541,RF02540 URS000080E357_9606 34315873 0003735 0005840 9606 gcuaaaccuagccccaaacccacuccaccuuacuaccaaaccuuagccaaaccauuuacauaaaguauaggcgauagaaauugggcgcaauagauauaguaccgcaagggaaagaugaaaaauaccaagcauaauauagcaaggacuaaccccuauaccuucugaugaauuaacuagaaauaacuuugcaaggagagccaaagcuaagacccccgaaaccagacgagcuaccuaagaacagauuuauagguagaggcgacaaaccuaccgagccuggugauagcugguuguccaagauagaaucuuaguucaacuuuaaauuugcccacagaaccaaauccccuuguaaauuuaacuguuaguccaaagaggaacagcucuuuggacacuaggaaaaaaccuuguagagagaguaaaaaauuuaacacccauaguaggccuaaaagcagccaccaauuaagaaagcguucaagcucaacaccucccaaacauauaacugaacuccucacacccaauuggaccaaucuaucacccuauagaagaacuaauguuaguauaaguaacaugaaaacauucuccuccgcauaagccugcgucagaucacugacaauuaacagcccaauaucuacaaucaaccaacaagucauuauuacccucacugucaacccaacaggcaugcucauaaggaaagguuaaaaaaaguaaaaggaaacaucaccucuagcaucaccaguauuagaggccagcugucucuuacuuuuaaccagugaaauugaccugcccgugaggcgggcauaacacagcaagacgagacccuauggagcuuuaauuuauuaaugcaaacaccugcauuaaaaauuucgguuggggcgaccucggagcagaacccaaccuccgagcaguacaugcuaagacuucaccagucaaagcgaaccucaauugauccaauaacuugaccaacggaacaaguuacccuaggguaucuacuuuauuccucccuguacgaaaggacaagagaaauaaggccuacuucacaaagcgccuucuaaaugauaucaucucaacuuaauacccacacccaagaacaggguu <<<.......<<<<..................................<......>.....<.....<<.....>>....>..>>.>>.............<<....>>..................>>>...........<<<.......>>>...<.<....>.>.<<<<<<.........<<<.<<..<<....>>...>>.>>>...<<.<...<<<<.<.....<<<<<.<<<....>>>.>>>>>...<<.......>>......>.>>>>......>.>>..<<<<<<....<<<<....>>>><<<.<<<<<<<<<<.....<<......>>.....>>>>>>>>>>..>>>.<<<<<<<<<<......>>>>>>>>>>...<<<......>>>....<<<.<<<...<..............<....<<<.........>>>....>.......<<<......>>>......................>...>>>>>>........>>>>>>...<<<<<......>>>>>.........>>>>>><......<<..<<<....>>><<<<..<<<<........<<<<<....>>>>>......<<<...<<<<.......................>>>>.......>>>.....<<....>>.>>>>.....>>>>..<<<<...<<<<<<<<.<<.........<<<<<<.............>>>>>>........>>.>>>>>>>>>>>>.>>.....>.....<<<<<.....>>>>>.......<<..<<<.....<<<<<.<<<<<<..<<<<<.<<<<<<<<......>>>>>>>>>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<.....<<<..<<<<.....>>>>..>>>....>>.........<<<....>>>............>>>>..>>>>>>>..>>>.>>..<<<.<<<.................>>>.>>><<<<<...<<<....>>>.>>>>>.<<<.<............>.>>>........<<<<.......>>>>. ((.....(..((((..................................(...[..).....(.....((.]...))....)..)).)).............((....))....)..............)).........(.(((.......))).{.(.(....).).((((((.........(((.((..((....))...)).)))...((.(...((((.(.....(((((.((((.).))).))))).(.((.......))...)..).))))......).))..((((((....((((....))))(((.((((((((((.....((......)).....))))))))))..))).((((((((((......))))))))))...(((......)))....(((.(((...(..............(.(..(((.........)))..).)....(..(((......)))).....................)...))))))........))))))...(((((......))))).........))))))(......((..(((....)))((((..((((......(.(((((....)))))......(((...((((...............(..)....)))).......))).)...((....)).)))).....))))..((((....(((((((.((..(......((((((.............)))))).......))).))))))).)))).)).....)).[..(((((..}].))))).......((..(((.....(((((.((((((..(((((.((((((((......)))))))))))))..(((......[)))((((((..........]))))))(.((.....((...(((....[..)))...))....)).........(((....))).....)].....))))..)))))))..))).))..(((.(((......(....).....))).)))(((((...(((....))).))))).(((................)))........((((.......)))). Cryo-EM structure of late human 39S mitoribosome assembly intermediates, state 3C; 16S rRNA 7oid A 1472 3.7 RF02541,RF02540 URS000080E357_9606 34315873 0003735 0005840 9606 gcuaaaccuagccccaaacccacuccaccuuacuaccagcaaccuuagccaaaccauuuacaaauaaaguauaggcgauagaaauugauggcgcaauagauauaguaccgcaagggaaagaugaaaaauuauaaccaagcauaauauagcaaggacuaaccccuauaccuucugcauaaugaauuaacuagaaauaacuuugcaaggagagccaaagcuaagacccccgaaaccagacgagcuaccuaagaacagcuaagagcacacccgucuauguagcaaaauagugggaagauuuauagguagaggcgacaaaccuaccgagccuggugauagcugguuguccaagauagaaucuuaguucaacuuuaaauuugcccacagaaccaaauccccuuguaaauuuaacuguuaguccaaagaggaacagcucuuuggacacuaggaaaaaaccuuguagagagaguaaaaaauuuaacacccauaguaggccuaaaagcagccaccaauuaagaaagcguucaagcucaacaccaaaaaucccaaacauauaacugaacuccucacacccaauuggaccaaucuaucacccuauagaagaacuaauguuaguauaaguaacaugaaaacauucuccuccgcauaagccugcgucagauacugacaauuaacagcccaauaucuacaaucaaccaacaagucauuauuacccucacugucaacccaacacaggcaugcucauaaggaaagguuaaaaaaaguaaaaggaacucggcaaaucuuaccccgccuguuuaccaaaaacaucaccucuagcaucaccaguauuagaggcaccgccugcccagugacacauguuuaacggccgcgguuaaccgugcaaagguagcauaaucacuuguuccuuaaauagggaccuguaugaauggcuccacgaggguucagcugucucuuacuuuuaaccagugaaauugaccugcccgugaagaggcgggcauaacacagcaagacgagaagacccuauggagcuuuaauuuauuaaugcaaacaguaaccugcauuaaaaauuucgguuggggcgaccucggagcagaacccaaccuccgagcaguacaugcuaagacuucaccagucaaagcgaaccucaauugauccaauaacuugaccaacggaacaaguuacccuagggauaacagcgcaauccuauucuagaguccauaucaacaauaggguuuacgaccucgauguuggaucaggacaucccgauggugcagccgcuauuaaagguucguuuguucaacgauuaaaguccuacgugaucugaguucagaccggaguaauccaggucgguuucuaucuacuuuauuccucccuguacgaaaggacaagagaaauaaggccuacuucacaaagcgccuucccccguaaaugauaucaucucaacuuagauacccacacccaagaacaggguu <<<.......<<<<....................................<......>.......<.....<<.....>>....>....>>.>>.............<<....>>......................>>>...........<<<.......>>>...<.<........>.>.<<<<<<.........<<<.<<..<<....>>...>>.>>>...<<.<...<<<<.<.....<<<<<.<<<..<<<...>>>...<<<<.<<<<........>>>>>>>>....>>>.>>>>>...<<.......>>......>.>>>>......>.>>..<<<<<<....<<<<....>>>><<<.<<<<<<<<<<.....<<......>>.....>>>>>>>>>>..>>>.<<<<<<<<<<......>>>>>>>>>>...<<<......>>>....<<<.<<<...<..............<....<<<.........>>>....>.......<<<......>>>...........................>...>>>>>>........>>>>>>...<<<<<......>>>>>.........>>>>>>.......<<..<<<....>>><<<<..<<<<........<<<<<...>>>>>......<<<...<<<<.......................>>>>.......>>>.....<<......>>.>>>>.....>>>>..<<<<...<<<<<<<<.<<.........<......<<<<<<..<<<.........>>>...<<<<<<.............>>>>>>....<<<.<<<..<<<<<....>>>..>>>>><<<<<....>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>....>>.>>>>.....>..>>.>>>>>>>>>>>>.>>...........<<<<<........>>>>>.......<<..<<<.<<......<<<<.<<<<<<..<<<<..<<<<<<<<..........>>>>>>>>.>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<.....<<<..<<<<.....>>>>..>>>....>>.........<<<....>>>............>>>>..>>>>>>.......<<<..<.<<<<<<...<<.......>>...>>>>>>...>.>>.>.......<<<<<.<<<<<<..<<.<<<<<<......>>>>>>...>>.<<<<<.....>>>>>.....>>>>>..>...>>>>.>....<<<<<<<....>>>.>>>>....>>..>>>.>>..<<<.<<<.................>>>.>>><<<<<...<<<....>>>.>>>>>......<<<................>>>.........<<<<.......>>>>. ((.....(..((((....................................(...[..).......(.....((.]...))....)....)).)).............((....))....)..................)).........(.(((.......))).[.(.(........).).((((((.........(((.((..((....))...)).)))...((.(...((((.(.....(((((.((((.(((..[)))...(((..((((.......{)))).)))..).))).))))).(.((.......))...)..).))))......).))..((((((....((((....))))(((.((((((((((.....((......)).....))))))))))..))).((((((((((......))))))))))...(((......)))....(((.(((...(..............(.(..(((.........)))..).)....(..(((......))))..........................)...))))))........))))))...(((((......))))).........))))))(......((..(((....)))(((...((((......(.(((((...)))))......(((...((((...............(..)....)))).......))).)...((......)).))))......)))..((((....(((((((.((..(....(........((((((.].((.........))....((((((.............))))))....(((.(((..(((((....)))..)))))(((((....)))))........((..........(((((.......)))))..)..)....)))....)).))))....)..))).))))))).)))).)).....)).{..(((((.....]}.))))).......((..(((.((......((((.((((((..(((((.((((((((..........)))))))))))))..(((......[)))((((((..........]))))))(.((.....((...(((....[..)))...))....)).........(((....))).....)].....))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......((((.((((((..((.((((((......))))))...)).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..}.))..))).))..(((.(((......(....).....))).)))(((((...(((....))).)))))......(((................))).........((((.......)))). Cryo-EM structure of late human 39S mitoribosome assembly intermediates, state 5A; 16S rRNA 7oif 1 2903 3.0 RF02540,RF02541 URS00021ED9BC_562 34994471 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaacccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<<.....>>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<<..<<<.........>>>..>>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<<.<<....>>..>>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<.<..<<<...............<....<.......<<<<<<<......>>>>>>>....>..............>......>>>..>.>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((.(.(.....).).).))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..((...........))..)))........(((......)))..)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((..((....))..)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((...((((.(.............(..(((........(.((.(....).)).).....)))............)....).))))...)))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(.(((((....))).)).)....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). CspA-27 cotranslational folding intermediate 2; 23S rRNA 7oif 2 1534 3.0 RF00177,RF01959,RF01960 URS000081169C_562 34994471 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<......>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<<....>>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<....>>>>>>..............>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((........))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((((.......)))))))).....)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((..((....))..))).............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... CspA-27 cotranslational folding intermediate 2; 16S rRNA 7oif 3 120 3.0 RF00001 URS0000049E57_562 34994471 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). CspA-27 cotranslational folding intermediate 2; 5S rRNA 7oif z 88 3.0 RF00005 URS0001DD2ACB_562 34994471 0030533 0006412 562 ggugagguguccgagungcugaaggagcacgccuggaaaguguguauacggcaacguaucgggggnucguaucccccccucaccgcca <<<<<<<..<<<...........>>><<<<<<.......>>>>>><<<<<....>>>>>.<<<<<.......>>>>>>>>>>>>.... (((((((..(((.....[.....))).((((.........))))..((((....))))..(((((..]....)))))))))))).... CspA-27 cotranslational folding intermediate 2; tRNA-Ser 7oig 1 2903 3.2 RF02540,RF02541 URS00021ED9BC_562 34994471 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaacccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<.......>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<<..<<<<.......>>>>..>>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<.<.<<<...<<<....>>>...>>>..>>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<<.<<....>>..>>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<.<<.<<<....................<........<...<<<....>>>...>.....>.....................>>>.>>.>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((((.(.....).))).))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..((...........))..)))........(((......)))..)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((..((....))..)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((((((((.(((((.(.............(....(........(..((......).).).....)..............)....).)))).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(.(((((....))).)).)....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). CspA-27 cotranslational folding intermediate 3; 23S rRNA 7oig 2 1534 3.2 RF00177,RF01959,RF01960 URS000081169C_562 34994471 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<......>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<....>>>>>>..............>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((........))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((((.......)))))))).....)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...((.(((....))).))..............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... CspA-27 cotranslational folding intermediate 3; 16S rRNA 7oig 3 120 3.2 RF00001 URS0000049E57_562 34994471 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). CspA-27 cotranslational folding intermediate 3; 5S rRNA 7oig z 88 3.2 RF00005 URS0001DD2ACB_562 34994471 0030533 0006412 562 ggugagguguccgagungcugaaggagcacgccuggaaaguguguauacggcaacguaucgggggnucguaucccccccucaccgcca <<<<<<<..<<<...........>>><<<<<<.......>>>>>><<.<<....>>.>>.<<<<<.......>>>>>>>>>>>>.... (((((((..(((.....[.....)))(((((.........))))).(((.(...))))..(((((..]....)))))))))))).... CspA-27 cotranslational folding intermediate 3; tRNA-Ser 7oii 1 2903 3.0 RF02540,RF02541 URS00021ED9BC_562 34994471 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaacccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<<.....>>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<<..<<<<.......>>>>..>>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<<.<<....>>..>>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<.<..<<<............<<<<<...<.......<<<<<<<<....>>>>>>>>....>.............>>>>>...>>>..>.>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((((.(.....).))).))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..((...........))..)))........(((......)))..)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((..((....))..)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((...((((.(..........((((...(........((..(((....)))..))......)............)))).).))))...)))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(.(((((....))).)).)....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). CspA-70 cotranslational folding intermediate 2; 23S rRNA 7oii 2 1534 3.0 RF00177,RF01959,RF01960 URS000081169C_562 34994471 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<......>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>.............>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((........))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((((.......)))))))).....)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((..((....))..)))....(....)...))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... CspA-70 cotranslational folding intermediate 2; 16S rRNA 7oii 3 120 3.0 RF00001 URS0000049E57_562 34994471 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). CspA-70 cotranslational folding intermediate 2; 5S rRNA 7oii z 85 3.0 RF00005 URS0000036214_562 34994471 0030533 0006412 562 gcgggagnggcgaaauuggnagacgcaccagauuuaggnncnggcgccgcaaggngngcgagnncaagncncgccncccgcacca <<<<<<<..<<<...........>>>.<<<<<.......>>>>>.<<<....>>>..<<<<<.......>>>>>>>>>>>>.... (((((((..(((......[....))).((((.........))))..((....))...(((((..]....)))))))))))).... CspA-70 cotranslational folding intermediate 2; tRNA-Leu 7oiz A 1519 2.9 RF00177,RF01959,RF01960 URS00023119D3_83333 34403461 0003735 0005840 83333 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugccggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<......>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<.>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<.......<<<....>>>......>>>>...<.<<<<<.......<<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<..>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((((((......)))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....(((.((.)).))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((((())))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((..(((.(((....))).)))...(......)..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....))))))))..)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Cryo-EM structure of 70S ribosome stalled with TnaC peptide; 16S rRNA 7oiz a 2753 2.9 RF02540,RF02541 URS0002311999_83333 34403461 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagcgucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcgcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<<..>>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<..>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<..>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.......<<<<<<.<<....>>..>>>>>>.......>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<..>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((((((.....))))).))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(())...)))..))))).))...........]]].)...))))))))))...)))))))((((((((()))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((())))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).).....((.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..))....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Cryo-EM structure of 70S ribosome stalled with TnaC peptide; 23S rRNA 7oiz b 119 2.9 RF00001 URS000080E133_83333 34403461 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>> ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))) Cryo-EM structure of 70S ribosome stalled with TnaC peptide; 16S rRNA 7oiz V 75 2.9 RF00005 URS00023119E1_83333 34403461 0030533 0006412 83333 cggcacguagcgcagcgguagcgcaccgucauggggugucgggggucggaggnucaaauccucucgugccgacca <<<<<<<..<<<<.......>>>>.<<<.<<.....>>.>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((....[..)))).(((.(.......).))).....(((((..]....)))))))))))).... Cryo-EM structure of 70S ribosome stalled with TnaC peptide; tRNA 7oj0 A 1519 3.5 RF00177,RF01959,RF01960 URS00023119D3_83333 34403461 0003735 0005840 83333 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugccggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<......>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<.>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<..>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>........<.<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>>..>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((((((......)))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....(((.((.)).))).)))))))..)).)))))))(((....(((..((((((.(.......).)))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(...((((.((((.......)))).))).)...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((((())))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((.(((....))).)))...(......)..))))).))).((.((....((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...))..))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Cryo-EM structure of 70S ribosome stalled with TnaC peptide and RF2; 16S rRNA 7oj0 a 2807 3.5 RF02540,RF02541 URS00023119BB_83333 34403461 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcgcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<.<....<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>..>>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<..>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<<.<<....>>..>>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<..>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>.(<<...<<<<<<<...<<<<<<.......>>>>>>.....<<)..(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((.((((.....))))..))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(.(.....{.(((((.(((..((((.......))))..))).....(..(((......)))).)))))...).)..))))).))...........]]].)...))))))))))...)))))))((((((((()))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((())))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Cryo-EM structure of 70S ribosome stalled with TnaC peptide and RF2; 23S rRNA 7oj0 b 119 3.5 RF00001 URS000080E133_83333 34403461 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>> ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))) Cryo-EM structure of 70S ribosome stalled with TnaC peptide and RF2; 5S rRNA 7oj0 V 75 3.5 RF00005 URS00023119E1_83333 34403461 0030533 0006412 83333 cggcacguagcgcagcgguagcgcaccgucauggggugucgggggucggaggnucaaauccucucgugccgacca <<<<<<<..<<<<.......>>>>.<<<.<<.....>>.>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((....[..)))).(((.(.......).))).....(((((..]....)))))))))))).... Cryo-EM structure of 70S ribosome stalled with TnaC peptide and RF2; tRNA 7ojk D 12 3.89 URS0002311A2D_11620 34857749 11620 gggauccuaggc ............ ............ Lassa virus L protein bound to the distal promoter duplex [DISTAL-PROMOTER]; 5' RNA 7ojl E 13 3.3 URS0001A16A6C_11620 34857749 11620 gccuaggauccac ............. ............. Lassa virus L protein in a pre-initiation conformation [PREINITIATION]; 3' RNA 7ojl D 20 3.3 URS0002311972_11620 34857749 11620 gcgcaccggggauccuaggc .<.....>............ .(.....)............ Lassa virus L protein in a pre-initiation conformation [PREINITIATION]; 5' RNA 7ojn R 11 2.92 URS0001A16A6C_11620 34857749 11620 uccacugugcg ........... ........... Lassa virus L protein in an elongation conformation [ELONGATION]; 3' RNA 7olc 1 3191 2.9 RF02540,RF02543 URS000051B013_759272 35079002 0003735 0005840 759272 guugaccucggaucagguaggaggacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaacagggauugcccuaguaacggcgagugaagcggcaacagcucaaauuugaaagcuggcuucggcccgcguuguaauuuggagaggaugcuuugggcgaggcuccuucugaguucccuggaacgggacgccacagagggugagagccccguauaguuggaagccaagccuguguaaagcuccuucgacgagucgaguaguuugggaaugcugcucaaaaugggagguaaauuucuucuaaagcuaaauaccggccagagaccgauagcgcacaaguagagugaucgaaagaugaaaagcacuuugaaaagaggguuaaauagcacgugaaauuguugaaagggaagcgcuugugaccagacuugcgcccggcggaucauccgguguucucaccggugcacuccgccgggcucaggccagcaucgguucuggcggggggauaaaggcccagggaauguggcuccuccgggaguguuauagcccuggguguaauacccucgccgggaccgaggaccgcgcucugcaaggaugcuggcguaauggucaccagcgacccgucuugaaacacggaccaaggagucaagguuuugcgcgaguguuuggguguaaaacccgcacgcguaaugaaagugaacguaggugagagcuucggcgcaucaucgaccgauccugauguauucggauggauuugaguaggagcguuaagccuuggacccgaaagauggugaacuaugcuuggauagggugaagccagaggaaacucugguggaggcucgcagcgguucugacgugcaaaucgaucgucaaaucugagcaugggggcgaaagacuaaucgaaccaucuaguagcugguuaccgccgaaguuucccucaggauagcagugucgaccuucaguuuuaugagguaaagcgaaugauuagggacucgggggcgauuuuuagccuucauccauucucaaacuuuaaauauguaagaagcccuuguuacuuaacugaacgugggcauucgaauguaucgacacuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacgcgggguuaaggugccggaguggacgcucaucagacaccacaaaaggcguuaguacaucuugacagcaggacgguggccauggaagucggaauccgcuaaggacuguguaacaacucaccugccgaauguacuagcccugaaaauggauggcgcucaagcgucccacccauaccccgcccucaggguagaaacgaugcccugaggaguaggcggccguggaggucagugacgaagccuagggcgugagcccgggucgaacggccucuagugcagaucuuggugguaguagcaaauacuucaaugagaacuugaaggaccgaaguggggaaagguuccaugugaacagcgguuggacauggguuagucgauccuaagccauagggaaguuccguuucaaaggggcacucgugccccguguggcgaaagggaagccgguuaauauuccggcaccuggauguggguuuugcgcggcaacgcaacugaacgcggagacgacggcgggggccccgggcagaguucucuuuucuucuuaacggucuaucacccuggaaacaguuugucuggagauaggguuuaauggccggaagagcccgacacuucugucggguccggugcgcucucgacgucccuugaaaauccgcgggagggaauaauucucacgccaggucguacucauaaccgcagcagguccccaaggugaacagccucugguugauagaacaauguagauaagggaagucggcaaaauagauccguaacuucgggaaaaggauuggcucuaaggguugggcacguugcggcgugcgguuaacaaccaacuuagaacugguacggacagggggaaucugacugucuaauuaaaacauagcauugcgauggccagaaagugguguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcaaaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaaaagacauaggagcuccuauuguuuuuuuacuuauucaaugaagcggggcuggacuugcguccaacuucuggaguuaagguccuucgcgggccgacccggguugaagacauugucagguggggaguuuggcugnggcggcacaucuguuaaaccauaacgcagguguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaaguccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucgaaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaacucgucgcaaugguaauucagcuuaguacgagaggaaccgcugauucagauaauugguuuuugcgguuguccgaccgggcagugccgcgaagcuaccaucugcuggauaauggcugaacgccucuaagucagaauccaugccagaacgcgacgauacuacccgcacguuguagacguauaagaauaggcuccggccucguauccuagcaggcgauuccuccgccggccucgaaguggccgucgguaauucgcguauugcaauuuagacacgcgcgggaucaaauccuuugcagacgacuuagaugugcgaaaggguccuguaagcaguagaguagccuuguuguuacgaucugcugaggguaagcccuccuucgccuagauuu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<....>>>.>>.......>>....<<<<<.<<<<<<<<<..<<<<<<....<...<<<<......>>>>.((......<<<.....))>>>.>......>>>.>>>..>>>>....>>>>>>>>.>>........<<<<<<<........>>>>>>>.....(((((.<<<<<<<)))))..]]]..................................<<....>>...............<<<......>>>..................................<<<<.<<<<<<.....<<.<<<<<<<<<.....<<<<<<....>>>>>>......>>>>>>>>>.>>.<<<<<<<.<<<<<<<<<<<<<<<.....<.<<<<<<<<......<<<<<....>>>>>.......>>>>>>>>....>.>>>>>>>>>>>>>>>........<<...>>.....>>>>>>>.....>>>>>>.>>>>..<<<<........>>>><<<<<<....<<<<<<<<.<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<..>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>.>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>...<<<<<....<.<<<....>>>.><<<<<<<<<.....<<.<<<<<<<.....<<<....<<<....<<<...<<<<<<........>>>>>>.>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>...>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<......<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>....>>>>>>.>>>...>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<...<<<....>>>........<<<<<......>>>>>....>>>....>>...<<<<<........>>>>>))<<<<.<<<<.<<<....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<.<<<<.......>>>>.><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>.........>>>...>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<.....<..>......>>>>><<.<<<<<<<<<<<.<<<<<<....>>>>>>......>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<....<<<<<....>>>>.>...>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<<<<<<<<..>>>>>.>>>>>>>>>>>...<<<<<.....<<<<..<<<<<....>>>>>..............<<<<<.....>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..(((..>>>>>>>)))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<..<<<<<..<.<<<<<<<......>>>>>>..>.>.<<<.........>>>.....>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<..<<<<.<.<<<<<.................>>>>>.><<<<<...<<<<....<<<<<<<<<......>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>.....<<<<<.<..<<<......<<.......<<<<..>>>>....>>........<<<<.....<<<.<<<<<.......>>>>>.>>>....>>>>..............>>>.>.>>>>>...<<<<<<<.............>>....<<<<<<<<<.<<<....<<<<.<..<<<<<......>>>>>..>>>>>...>>>....>>>>..>>>>>...>>>>> .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((.(.........(((.(((....))).))....)........(((((.(((((((((..((((((..((..({((((......)))))[[(...).(((....}]])))....))..)).))))..))))....)))))))).))...)....(((((((........))))))).....(((((..[[[[[[)))))...))..................................((....))............(..((((....))))............).....................((((.((((((.....((.(((((((((((...((((((....))))))...).)))))))))).)).(((((((((((((((((((((((.......((((((((......(((((....))))).......))))))))......)))))))))))))))........((...))....)))))))).....)))))).)))).[((((........))))((((((....((((((((.((((..(((...(((.......)))...)))...((....)).......(((((..((....))...))))).((((((((....(....)....))).))).))....)))).))))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((........)))).)))....))))))))).(.((.......))...)..))))))......).))...(((((....(.(((....))).)(((((((((.....((.(((((((.....(((....(((..(.(((...(.(((((.....).)))).).))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))...))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((..((...((.........))...))......(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((..(((((((...((.....)).))))))....[[(((.((...(((...(((....)))........(((((......)))))....)))....))...(((((........)))))]]((((..(((.(((...((((....)))...(.<.((((((...((((.(((((((((((((.((((...{{..)))).)(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....)))...))).)))).))).))).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((.((((...()...))))......)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..((.(((((((((((((()))))).)))))))).))....((((.....((((..(((((....)))))...........>..(((((.....)))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))....))..))).)))))....(((((((..(((..(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...))))..)))....))))))).....(((((.((..((....(.((.......(((....)))....))).......((((.....(((.(((((.......))))).)))....))))..............)).)).)))))...(((((((..(.......)..))..(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....))))..))))))..))))) Thermophilic eukaryotic 80S ribosome at idle POST state; 26S rRNA 7olc 2 1765 2.9 RF01960,RF01959,RF00177 URS0002311978_759272 35079002 0003735 0005840 759272 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...<<<<<.{.[[[[>>>>><<<<.<<<<<<...<.<...<......<<<.<<<..<<....<<....<<.........>>...>>.>>......<<........<<<..<<..<<....<<<........<<.....<..<<.......>>..>......>>........<<<<<..........>>>>><...<<<<<<......(((((((.<<<<....>>>>..............>>>>>>.....>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<<..>>>.>...>>>>>>.........<<<....<<<.....>>>..>>>..>....>.>....<<<<<<<<<<<<<......>>>>>>>>.>>>>>.....<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>>.........<<<[[.....<.<<...<<<.<<....<<<<<<<<<<<<<<<<..>>>>>.>>>>>>>>>>>....<<<<<<....<<<...<<..>>....>>>....>>>>>>...<<<<<.<<.......<<..<<.......>>.<<<....>>>....>>......>>.>>..>>>.........<<<.<<<<<<<<<.....))))))).>>>>>>>>>>>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>.>.>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<.......>>>>>>>>>>>..>>>...<<..]]>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..]]]].}<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<......<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<......>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<<<<<<<<....>>>>>>>>..>>>>..>>>>.>>....<<<<<<....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>.......>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<<.<<<<....>>>>.>>>....>>.......>>>>>>>......<....<<<<<<..........>>>>>>....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<..<<<<.<<....<<<<<<<<.<<<..<<.<..<...<<<<<<<.<<<.<<<<<....>>>>>.>>>.>>>>>>>...>..>.>>..>>>.>>>>>>>>...>>.>>>>...>.>>.........<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((.........))...)){))......(((.......(((..((..((....(((....{...((.....(..(((.....)))..)......))........(((((..........)))))(.(.((((((......[[[[[[[[.(((....)))......(......).)))))).)...).(}((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).)....((((((((.(..((....))..).))).)))))...(.(.(.(...........))..)......)..((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((((((((((.(()).))).)))))))))))....((((((....(((...((()))....)))....))))))...(((((.((.......((..((.......)).(((....)))....))......)).))..))).........(((.((.((.(((....]]]]]]]].))).)).))))).....))...(((..((.((...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)).))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((.......)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.(.((((......((........))..........(((((.(....(((((........((.(((........))).))......)))))....(.(((...(.((((((.(..(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..((((((((.(((....))).))))..))))..)))).))..(.((((((....))))))....)..))))).)..))).))).....).))))......).)))))...)).)).).))).(...(((((((......((.....(((.((((....)))).)))....)).......)))))))......(.....(((((..........))))).....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..((.(..(...(((((((..((.(((((....))))).))..)))))))...)..).))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>........ Thermophilic eukaryotic 80S ribosome at idle POST state; 18S rRNA 7olc 3 119 2.9 RF00001 URS00006BED5F_759272 35079002 0003735 0005840 759272 acauacgaccauaccuaguggaaaacucgggaucccguccgcucucccauagauaagccacuaagggcgggguuaguacucaggucggugacgacuggggaaucccccguguuguaugu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>...>>....>>>>>>.>><<<<<<......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>> (((((((((....((((((((.....((((((...(....)...))))...))....)))))).))((((((......(((((..((....)).))))).....))))))))))))))) Thermophilic eukaryotic 80S ribosome at idle POST state; 5S rRNA 7olc 4 156 2.9 RF00002 URS000029C274_759272 35079002 0003735 0005840 759272 aaacuuucaacaacggaucucuugguucuggcaucgaugaagaacgcagcgaaaugcgauaaguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgcccgccgguauuccggcgggcaugccuguucgagcgucau .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))................... Thermophilic eukaryotic 80S ribosome at idle POST state; 5.8S rRNA 7old 1 3192 3.0 RF02540,RF02543 URS000051B013_759272 35079002 0003735 0005840 759272 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.........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<..>>>>.>>.......>>....<<<<<.<<<<<<<<<..<<<<<<........<<<<......>>>>.((......<<<.....))>>>........>>.>>>>..>>>>....>>>>>>>>.>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<.<<<<<<.....<<.<<<<<<<<<.....<<<<<<....>>>>>>......>>>>>>>>>.>>.<<<<<<<.<<<<<<<<<<<<<<<.....<.<<<<<<<<......<<<<<....>>>>>.......>>>>>>>>....>.>>>>>>>>>>>>>>>........<<...>>.....>>>>>>>.....>>>>>>.>>>>..<<<<........>>>><<<<<<....<<<<<<<<.<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<..>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>.>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>...<<<<<....<.<<<....>>>.><<<<<<<<<.....<<.<<<<<<<.....<<<....<<<..<.<<<...<<<<<<........>>>>>>.>>>.>..>>>..>>.>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>...>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>...>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<....<<.....>>..>>>>>....((<<<<<<...<<<...<<<....>>>........<<<<<......>>>>>....>>>....>>...<<<<<........>>>>>))<<<<.<<<<.<<<....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<.<<<<.......>>>>.><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>.........>>>...>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<.......<....>...........>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<<<<<<<<..>>>>>.>>>>>>>>>>>...<<<<<.....<<<<..<<<<<....>>>>>..............<<<<<.....>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>..>>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<..<<<<.<.<<<<<.................>>>>>.><<<<<...<<<<....<<<<<<<<<<....>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>.....<<<<<....<<<......<<.......<<.......>>...>>........<<<<.....<<<.<<<<<.......>>>>>.>>>....>>>>..............>>>...>>>>>...<<<<<<<.............>>....<<<<<<<<<.<<<....<<<<.<..<<<<<......>>>>>..>>>>>...>>>....>>>>..>>>>>...>>>>> .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.(((....))).))....)........(((((.(((((.(((..((((((..((..({((((......)))))[[(...).(((....}]])))....))..)).))))..))).....)))))))).))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((.((((((.....((.(((((((((.(...((((((....))))))...)..))))))))).)).(((((((((((((((((((((((........(((((((......(((((....))))).......))))))).......)))))))))))))))........((...))....)))))))).....)))))).)))).<((((........))))((((((....((((((((.((((..(((...(((.......)))...)))...((....)).......(((((..((....))...))))).((((((((....(....)....))).))).))....)))).))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((........)))).)))..).))))))))).(.((.......))...)..))))))......).))...(((((....(.(((....))).)(((((((((.....((.(((((((.....(((....(((..(.(((...(.(((((.....).)))).).))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))...))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.......(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((..(((((((...((.....)).))))))....[[(((.((...(((...(((....)))..(.....(((((......)))))..).)))....))...(((((........)))))]]((((.((((((((...((((....)))...(.[[(((.(....((((.(((((((((((((.((((...{{..)))).)(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)......))))...))....))).).)))))))).))).))).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((....(....().....).......)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(...(......((((....))))......).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.((((((((..((.(((((((((((((()))))).)))))))).))....((((.....((((..(((((....)))))..........]]..((((.......))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))....))..))).)))))....(((((((..(((..(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.............))))...))))..)))....))))))).....(((((.(...((....(.((........(.......)....))).......((((.....(((.(((((.......))))).)))....))))..............))..).)))))...(((((((..(.......)..))..(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....))))..))))))..))))) Thermophilic eukaryotic 80S ribosome at pe/E (TI)-POST state; 26S rRNA 7old 2 1765 3.0 RF01960,RF01959,RF00177 URS0002311978_759272 35079002 0003735 0005840 759272 uaccugguugauucugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuauacagcgaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuacauggauaaccgugguaauucuagagcuaauacaugcugaaaaucccgacuucggaagggauguauuuauuagauuaaaaaccaaugcccuucggggcuuucuggugauucauaauaacuucucgaaucgcacggccuugcgccggcgaugguucauucaaauuucugcccuaucaacuuucgacggcuggguauuggccagccguggugacaacggguaacggaggguuagggcucgaccccggagaaggagccugagaaacggcuacuacauccaaggaaggcagcaggcgcgcaaauuacccaaucccgacacggggagguagugacaauaaauacugauacagggcucuuucgggucuuguaauuggaaugaguacaauuuaaaucccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugagguuaaaaagcucguaguugaaccuugggccuagcccgccgguacuggcugggcugggccuuuccuucuggagaaccgcaugccggugugucggggaaccaggacuuuuacucugaacaaauuagaucgcuuaaagaaggccuaugcuugaauacauuagcauggaauaauagaauaggacgugugguucuauuuuguugguuucuaggaccgccguaaugauuaauagggacagucgggggcgucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacaacugcgaaagcauucgccaaggauguuuucauuaaucaggaacgaaaguuaggggaucgaagacgaucagauaccgucguagucuuaaccauaaacuaugccgauuagggaucggacggcguuuauuuuugacccguucggcaccuuacgauaaaucaaaauguuugggcuccugggggaguauggucgcaaggcugaaacuuaaagaaauugacggaagggcaccaccagggguggagccugcggcuuaauuugacncaacacggggaaacucaccagguccagacacgaugaggauugacagauugagagcucuuucuugauuucgugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccugcuaaauagcccguauugccuuggcaguacgccggcuucuuagagggacuaucggcucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagauguucugggccgcacgcgcgcuacacugacagagccagcgaguacucccuuggccgagaggcccggguaaucuuguuaaacucugucgugcuggggauagagcauugcaauuauugcucuucaacgaggaaucccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuacuaccgauugaacggcucagugaggcuuucggacuggcccagagaggucggcaacgaccacucagggccggaaaguuauccaaacucggucguuuagaggaaguaaaagucguaacaaggucuccguaggugaaccugcggagggaucauuu ...<<<<<.{.[[[[>>>>><<<<.<<<<<<...<.<...<......<<<.<<<..<<....<<....<<.........>>...>>.>>......<<........<<<..<<..<<....<<<........<<.....<..<<.......>>..>......>>........<<<<<..........>>>>><...<<<<<<......(((((((.<<<<<..>>>>>....<<......>>>>>>>>.....>...<<<<.<<<<.....>>>>>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>...<<<..>>>.....>>>>>>.........<<<....<<<.....>>>..>>>..>....>.>....<<<<<<<<<<<<<......>>>>>>>>.>>>>>.....<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>>.........<<<[[.....<.<<...<<<.<<....<<<<<<<<<<<<<<<<..>>>>>.>>>>>>>>>>>....<<<<<<....<<<...<<..>>....>>>....>>>>>>...<<<<<.<<.......<<..<<.......>>.<<<....>>>....>>......>>.>>..>>>.........<<<.<<<<<<<<<.....))))))).>>>>>>>>>>>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<.<....>>>>>>>>>>>>..>>>...<<..]]>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..]]]].}<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<<<<<<<<....>>>>>>>>..>>>>..>>>>.>>....<<<<<<....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<<.<<<<....>>>>.>>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<.<..<...<<<<<<<.<<<.<<<<<....>>>>>.>>>.>>>>>>>...>..>.>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((.........))...)){))......(((.......(((..((..((....(((........((.....(..(((.....)))..)......))........(((((..(....)..)))))(.(.((((((......[[[[[[[..(((....)))......(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).)....((((((((.(.(.(....).).).))).))))).....(.(.(...........))..).........((((([[......((((.....((..]])).......)))).)))))..))))))))))..{......((({{...(.(.((...(((.((....((((((((((((((.(()).))).)))))))))))....((((((....((((...(())...).)).)...))))))...(((((.((.......((..((.......)).(((....)))....))......)).))..))).........(((.(((((.(((.....]]]]]]].))).)))))))).....))...(((..((.((...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)).))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((.......)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((........((.(((........))).))......)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..((((((((((((....))))))))..))))..)))).))..(.(((.((....).))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....(((.((((....)))).)))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..((....(...(((((((...(.(((((....))))).)...)))))))...)....))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>........ Thermophilic eukaryotic 80S ribosome at pe/E (TI)-POST state; 18S rRNA 7old 3 119 3.0 RF00001 URS00006BED5F_759272 35079002 0003735 0005840 759272 acauacgaccauaccuaguggaaaacucgggaucccguccgcucucccauagauaagccacuaagggcgggguuaguacucaggucggugacgacuggggaaucccccguguuguaugu <<<<<<<<<....<<<<<<<<.....<<<<<<............>>>>...>>....>>>>>>.>><<<<<<......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>> (((((((((....((((((((.....((((((...(....)...))))...))....)))))).))((((((......(((((..((....)).))))).....))))))))))))))) Thermophilic eukaryotic 80S ribosome at pe/E (TI)-POST state; 5S rRNA 7old 4 156 3.0 RF00002 URS000029C274_759272 35079002 0003735 0005840 759272 aaacuuucaacaacggaucucuugguucuggcaucgaugaagaacgcagcgaaaugcgauaaguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgcccgccgguauuccggcgggcaugccuguucgagcgucau .........................................<<<<<<.<<.....>>>.....(.<<<(.....>>............).>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>................... .........................................((((((.[[....[)))...].(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))................... Thermophilic eukaryotic 80S ribosome at pe/E (TI)-POST state; 5.8S rRNA 7old 5 75 3.0 RF00005 URS0000E60BA3_759272 35079002 0030533 0006412 759272 uccgauauagcguaacggcuaucacaucacgcuuucaccguggagaccgggguucgacuccccguaucggagcca <<<<<<<..<..............>.<<<<<.......>>>>>....<<<<<.......>>>>>>>>>>>>.... ((((((...(..............)..((((.......)))).....((((.........)))).)))))).... Thermophilic eukaryotic 80S ribosome at pe/E (TI)-POST state; pe/E tRNA 7onb G 14 3.1 URS000231196F_10535 34301950 10535 gaugaugucauacu .............. .............. Structure of the U2 5' module of the A3'-SSA complex; MINX 7onb H 32 3.1 RF00004 URS00003EE995_9606 34301950 0045131 0000348 0005686 9606 uaguaucuguucuuaucaguuuaauaucugau ..............<<<<<.<....>.>>>>> ..............(((((........))))) Structure of the U2 5' module of the A3'-SSA complex; RNU2 7ood 3 2879 3.4 RF02540,RF02541 URS0000AB9B3C_272634 36171285,36171285 0003735 0005840 272634 aguuacuaagggcuuaugguggaugccuuggcacuaauaggcgaugaaggacguguuaaccugcgauaagcuucggguaggugguaagaaccucagauccggagauuuccgaauggagcaauccgguaguuggaaacagcuaucauuaauugaugaauaaauagucaauuaaagcaauacguggugaagugaaacaucucaguagccacaggaaaagaaaacgaaugugauuccguguguaguggcgagcgaaagcggaacaggccaaacuuaucauuagauagggguuguagggcuugcaauguggacuugaaaacgauagaagaagcuguuggaaagcagcgcgcaaaagggugauagccccguauuugaaauuguuuucauaccuagcgagaucccugaguagcucggaaaacguuauuuugagugaaucugcccagaccauuggguaagccuaaauacuaauuagugaccgauagcgaaacaguaccgugagggaaaggugaaaagaacccagagaugggagugaaauagauucugaaaccauaugccuacaacgugucagagcacauuaaugugugauggcgugcguuuugaaguaugagccggcgaguuaugauagcaagcguuaguuaaccaggagauggggagcuguagcgaaagcgaguuuuaaaagagcguuuguuuguuauuauagacccgaaacggguugagcuagucaugagcagguugaagguugaguaacaucaacuggaggaccgaaccgacucucguugaaacgauagcggaugacuugugauuaggggugaaauuccaaucgaaauccgugauagcugguucucgucgaaauagcuuuaaggcuagcgugagaucacaaauaaguggagguaaagcuacugaauguaugauggcgccaccuaggcguacugaauacaauuaaacucugaaugccauuuauuuuauucucgcagucagacagugggggauaagcuucauugucaagaggggaagagcccagaucauuaaauaagguccccaaaauauacuaaguggaaaaggaugugaaagugcuaaaacagcaaggauguuggcuuagaagcagccaucguuuaaagagugcguaacagcucacuugucgaguguuuuugcgccgaagauguaacggggcuaaguauauuaccgaauuuauggauaagauuuauaucuugugguagacgagcguuguauuggaguugaagucaaagcgugagcauugguggauccaauacaagugagaaugccggcaugaguaacgcuugggagugagaaucucccaaaccgauugacuaagguuuccuggaccagggucguccuuccaggguuagucuggaccuaagcugaggcugaaaagcguaggcgauggacaacagguuaauauuccuguacuuacaguuagacugauggagugacaaagaagguuuuccacccccauaauuggauuuggggauaaaucauaaggugguacaauaggcaaauccguugugcauaacauugagugaugaugucgagugaaaguagcgaaggugguauuaaucaugcuuucaagaaaagcuucuaggguuaaucuagcuguaaccaguaccgagaacgaacacacguagucaaggagaggauccuaagguuagcgagugaacuauagccaaggaacucugcaaauuaaccccguaaguuagcgagaaggggugcuuauguaaaaguaagccgcagugaagaacgaggggggacuguuuaacuaaaacacaacucuaugccaaaccguaaggugauguauauggggugacaccugcccagugcuggaagguuaaagaaggagguuagcgcaagcgaagcuuuuaacugaagccccagugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuagucggguaaauuccgucccgcuugaaugguguaaccaucucuugacugucucggcuauagacucggugaaauccagguacgggugaagacacccguuaggcgcaacgggacggaaagaccccgugaagcuuuacuguagcuuaauauugaucaggacauuaucauguagagaauagguaggagcaaucgaugcaaguucgcuaggacuuguugaugcgaaagguggaauacuacccuugguugugugcuguucuaauugguaacuguuauccaguuucaagacaguguuaggugggcaguuugacuggggcggucgccuccuaaaagguaacggaggcguacaaagguaccuucaguacgguuggaaaucguauguagaguguaaugguguaagggugcuugacugugagacauacaggucgaacaggugagaaaucaggucauagugauccggugguccaguauggaauggccaucgcucaacggauaaaagcuacuccggggauaacaggcugauacugcccaagaguucauaucgacggcaguguuuggcaccucgaugucgacucaucucauccucgagcugaagcagguucgaaggguucggcuguucgccgauuaaagagauacgugaguuggguucaaaccgucgugagacagguuggucccuaucuauugugcccguaggaagauugaagaguguugcuucuaguacgagaggaccgaagcgaggacaccucuuaugcuccaguuguagcgccagcugcaccgcuggguaguaacgugucuauuagauaaacgcugaaagcaucuaagugugaaacuaucucaaagauuaaucuucccauuucgaaaguaagagccgucaaagacgaugacguugauagguuacagguguaagcauagugauauguugagcugaguaauacuaauugcucgaggacu <<<......<<<<.<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>....<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((....<<<<<......>>>>>......<<<<<<<<<.....<....<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>...>..>>>>>..>>>>.....<<<<<<<<.......>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<....>>>>.............}....>>>>>>.>>>>.......<<<<..<<<<......>>>>..>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<...<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<.<<........>>.>>>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<....<<<<<<<<<<......<<....<<..<<<<<...<.<<<<.....>>>>..>...>>>>>..>>..>>.......>>>>>>>>>>...>>>>>>.>>..<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((...<<<<<<<...........<<..<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>...>>>>>>>>>>.>>...........))).....>>>>>>>>>>...>>>>>>><<<<<<<....>>>>>>>....>>>>>><<<<<<<<<<<<......<<<<<.<<....>>.>>>>>...>>>>>>>>>>.>>.....>>>>>>.......<<...<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<<...<<<<...<<<..<<<<<<<<<....(((...>>>>><<..<<<<<..<<<<<<<<<<<.<<.....>>>>>>>>>....>>>>..>>>>>...>><..<<.......>>...>>>>>....>>>....>>>>........>>>>>..>>.....>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<<...<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<......>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<..<<<<<<..<<....>>...>>>>>>..>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<.<<<.......>>>.>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>>>>>>>>...........<<<<<........>>>>>..<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<<.<<.<<<.<<<<..<<<...........<<<<<..<<<......<<<<<<<......>>>>>>>...>>>.............>>>>>..>>>..>>>>.>>>.>>...<<<..<<<<<.....>>>>>.>>>....>>>>>>>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<<....<<<..<<<<<<<...............>>>>>>><<<<<<...<<<<...<<<<<<<<<<<.)))>>>>>>..>>>>>...>>>>.>>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>........>>>>>>>...<<..>>.....<<<<<<<<.........>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((.(((((.....(((..(((((((((((((......((((((....[[[.))).....((((((...(((]]]....)))......))))))...)))....(((....)))((((((((....)))))))).(((((((((.........))))))))).))....((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...(((((......)))))......(((((((((.....((...((((((((((.(((...(((((......)))))[[......(((.....]])))...)))...))))))))))..))..)))))..))))).....((((((((.[..).))))))).......(((((].[[[[)))))..)))......)).))))))).))...............((....))....)).........((((....)))).............).....))))).)))).....(.((((...(((..[...)))...)))).<.(.(........).).((((((....(((.(((((((((....((...(((.....)))...))....((....))..((((.....))))....))))))))).)))..((.(...(((.((.....((((((((((.((((...((((((......))))))...)<)))...(((.((.((........)).)))))..).))))))))).(.((.......))...)..)).)))......).))..((((((....(((((....)))))((((((((....((((((.(((.....(((....(((.(((((...(.((.(.....).))..)...))))).)))..)).).....))).))))))...)))))).))..((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(((((((.....(.....((..((((((..((.....{..((((.(((..(((.........)))..))).....(...((......)).).))))....))..)))))).))...........]]].)...))))))))))...)))))))(((((((....)))))))....))))))(.(((((..(((......(.(((.((....))])).))...)))..)))))..).....)))))).......((...((((((.......))))))((((....(((...((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((((((((((...(((((...((((..((((..(((((.(((.....{{...))).).(..(((((..((((..(((((.((.....)))))))......))))..)))))...).(..((.......))...)))))....))))...))))(..)....)))))..)).....))))))))))))))).))).....((......))..))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.[..).....)))))((((((......))))))(...).......(((((((((.>.((.........))...(((((((.....(((....))).......))))))).]((((.(((..(((((((..(((...((...(((((..((....))...)))).)..))...))))))))..)))))(((((.........)))))........((..........(.(((.......))).)..)..)....))))...)).))))))).)..))).)))))))).))))))......).[..(((((.....>].)))))..(((((((..(((.((......((((.((((((..(((((.(((((((((.((.(((.(((...(((.(......[..(((((..(((......(((((.(......).)))))...)))...........].)))))).)))...))).))).))...(((..(((((.....))))).)))....)))))))))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...)..(]..[[[).....)))))))...((((..(((...{..)))..)))).(((....))).))]]].......(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....))..))).)))))))[...(((((((....(((..(((((((.....(....)....)))))))((((((...((((...(((((((((((.}}.))))))..)))))...)))).))))))..(((....((((.....}.......))))....))).)))...]....)))))))(.(((())))....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))...)))) Mycoplasma pneumoniae 50S subunit of ribosomes in chloramphenicol-treated cells; 23S ribosomal RNA 7ood 4 105 3.4 RF00001 URS000000E851_272634 36171285,36171285 0003735 0005840 272634 uuuggugcccaugucgcuguggaaacaccugguuccauuucgaacccagcaguuaagcacaguggagccgaauguagcugcagugagaauaggaaagcaccaagc <<<<<<<<.....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<..<..<.<<<..>>>...>.>.>>...>>>>>>>>. .(((((((.....((((((((.....((((((...(.....)...))))..))....)))))).)).((.......(......).......))...))))))).. Mycoplasma pneumoniae 50S subunit of ribosomes in chloramphenicol-treated cells; 5S ribosomal RNA 7ope A 2814 3.2 RF02540,RF02541,RF00002 URS00021ED966_224308 34255840 0003735 0005840 224308 guuaaguuagaaagggcgcacgguggaugccuuggcacuaggagccgaugaaggacgggacgaacaccgauaugcuucggggagcuguaagcaagcuuugauccggagauuuccgaauggggaaacccaccacucguaauggagugguauccauaucugaauucauaggauaugagaaggcagacccggggaacugaaacaucuaaguacccggaggaagagaaagcaaaugcgauucccugaguagcggcgagcgaaacgggaucagcccaaaccaagaggcuugccucuugggguuguaggacacucuguacggaguuacaaaggaacgagguagaugaagaggucuggaaaggcccgccauaggagguaacagcccuguagucaaaacuucguucucuccugaguggauccugaguacggcggaacacgugaaauuccgucggaauccgggaggaccaucucccaaggcuaaauacucccuagugaccgauagugaaccaguaccgugagggaaaggugaaaagcaccccggaaggggagugaaagagauccugaaaccgugugccuacaaguagucagagcccguuaacgggugauggcgugccuuuuguagaaugaaccggcgaguuacgaucucgugcaagguuaagcagaagaugcggagccgcagcgaaagcgagucugaauagggcgcaugaguacguggucguagacccgaaaccaggugaucuacccauguccagggugaaguucagguaacacugaauggaggcccgaacccacgcacguugaaaagugcggggaugagguguggguaggggugaaaugccaaucgaaccuggagauagcugguucucuccgaaauagcuuuagggcuagccucaagguaagagucuuggagguagagcacugauuggacuaggggcccggguuaccgaauucagucaaacuccgaaugccaaugacuuauccuugggagucagacugcgagugauaagauccguagucgaaagggaaacagcccagaccgccagcuaaggucccaaaguauacguuaaguggaaaaggauguggaguugcuuagacaaccaggauguuggcuuagaagcagccaccauuuaaagagugcguaauagcucacuggucgagugacucugcgccgaaaauguaccggggcuaaacguaucaccgaagcugcggacuguucgaacagugguaggagagcguucuaagggcugugaagccagaccggaaggacugguggagcgcuuagaagugagaaugccgguaugaguagcgaaagaggggugagaauccccuccaccgaaugccuaagguuuccugaggaaggcucguccgcucaggguuagucgggaccuaagccgaggccgaaaggcguaggcgauggacaacagguugauauuccuguaccaccuccucaccauuugagcaauggggggacgcaggaggauaggguaagcgcgguauuggauauccgcguccaagcaguuaggcugggaaauaggcaaauccguuucccaaaggcugagcugugauggcgagcgcgaaguuccugauuccacacugccaagaaaagccucuagcgaggugagaggugcccguaccgcaaaccgacacagguaggcgaggagagaauccuaaggugaucgagagaacucucguuaaggaacucggcaaaaugaccccguaacuucgggagaaggggugcucuguuagggugcaagcccgagagagccgcagugaauaggcccaggcgacuguuuagcaaaaacacaggucucugcgaagccguaaggcgaaguauaggggcugacgccugcccggugcuggaagguuaagaggagcgcuuagcguaagcgaaggugcgaauugaagccccaguaaacggcggccguaacgguccuaagguagcgaaauuccuugucggguaaguuccgacccgcacgaaaggcgcaacgaucugggcacugucucaacgagagacucggugaaauuauaguaccugugaagaugcagguuacccgcgacaggacggaaagaccccguggagcuuuacugcagccugauauugaauguugguuugaccuucuaacccgccgcccuuaucgggcggggagacagugucaggugggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguucccucagaaugguuggaaaucauucgcagaguguaaaggcacaagggagcuugacugcgagaccuacaagucgagcagggacgaaagucgggcuuagugauccggugguuccgcauggaagggccaucgcucaacggauaaaagcuaccccggggauaacaggcuuaucucccccaagaguccacaucgacggggagguuuggcaccucgaugucggcucaucgcauccuggggcuguagucggucccaaggguugggcuguucgcccauuaaagcgguacgcgagcuggguucagaacgucgugagacaguucggucccuauccgucgcgggcgcaggaaauuugagaggagcuguccuuaguacgagaggaccgggauggacgcaccgcugguguaccaguuguucugccaagggcaucgcuggguagcuaugugcggacgggauaagugcugaaagcaucuaagcaugaagccccccucaagaugagauuucccauuccgcaaggaaguaagaucccugaaagaugaucagguugauaggucugagguggaaguguggcgacacauggagcugacagauacuaaucgaucgaggacuuaacc <<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<..[..((.>>>.....<<<<<<<..<<<))..]..>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<<<<<<<<.........>>>>>>>.>>.>>....<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<......<<.....>>.....>>>>...(((....<<<<<<<<....>>>>>>>>......<<<<<<<<<.....<<<<.......<<<<<<<<<<.<<<.....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>.>>>>>..>>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<......>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<.<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>......>>>>>.>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<...<<<<<<<<<.....<<<...<<<<<<<<...<<<<<<..>>>>.>>...>>>>>>>>..>>.>.....>>>>.>>>>>..>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<..>>>>>>....>>>>>><.<<<<<<<.<<......<<<<<.<<....>>.>>>>>...>>.>>>>>>>..>.....>>>>>><......<<....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<.<.<<<...<<<....>>>...>>>..>>>...<<<<<........>>>>>))<<<<..<<<<<<......<<...<<<<....<<<<..<<<..<<<.<<<<<<<<...(((....>>>>>><<..<<<<<..<<<<<<<<<<<.<<.....>>>>>>>>>...>>>>..>>>>>...>><..<..>...>>>>>>...>>>...>>>>.........>>>>..>>..>>>>>>.>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<<<<....<<<<....>>>>...>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>..<<<<.<<<..<<<<<<<..<<<<..<<...<<<<<<.<<....>>..>>>>>>...>>..>>>>>>>>>..>>>>><<<<<...>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>...>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<<.<<<.<<<<...>>>>.>>>....<<.<<<<<<.....>>>>>>>>.....>>>>>>>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.)))>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>>. (((((((......((((((((((.....(((..(((((((((((((......((((((..[..[[[)))...].((((((...(((]]..]..)))......))))))...)))....(((....)))(((((((......))))))).(((((((((.........))))))).)).))....((((((.....(...[..)......))))).).........((....))...((((......((.]...)).....))))...((((...(((((((((..)))))))))....{.(((((((((.....((((........(((((((((.(((...(.((((......)))))[[(...).(((.....]])))...)))...))))))))).)))).)))))..)))))....((((((((..[......))))))))....}.(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((..((((..[...))))..)))).<.(.(........).).((((((....(((((((.(((((..(((...(((.....)))...)))...((....))..((((.....))))......))))).)))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)<)))...(((.(((((.......A))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((...(((((((((.....(((...((((((((...((..((()))...))...))))))))..)).).....)))).)))))..))))))).))..(((((((.((......)).)))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((.(.....{.(((((.(((..(((.........)))..))).....(...((......)).).)))))...).)))))))).))...........]]].)...))))))))))...)))))))((((((()))))))....))))))(((((((((.((......(((((.((....))])))))...)).))))))).)).....))))))(......((....((((((.......))))))((((....(((...((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((.((((((......((...((((....((((..(((..(((.((((((((....{{....))))))((..(((((..(((((((((((.((.....)))))))))...))))..)))))...))(..(())...))))))...)))...))))(..).....))))..))..))))))))))))))).))).....((......))..))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.[..).....)))))(((((....((((....))))...)))))(...).......(((((((((.>.((.........))...(((((((.....(((....))).......))))))).]((((.(((..(((((((..(((...((...(((((..((....))...)))))...))...))))))))..)))))(((((...)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).[..(((((.....>].)))))..((((((((.(((.((......((((.((((((..(((((.(((((((((.(((.((.(...).)).)))....((.((((((.....)))))))).....)))))))))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..a.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..((((....))))....(((.(((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))....)))....))))))). RqcH DR variant bound to 50S-peptidyl-tRNA-RqcP RQC complex (rigid body refinement); 23S rRNA 7ope B 112 3.2 RF00001 URS00001CC3E3_224308 34255840 0003735 0005840 224308 ugguggcgauagcgaagaggucacacccguucccauaccgaacacggaaguuaagcucuucagcgccgaugguagucggggguuucccccugugagaguaggacgccgccaa <<<<<<<....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<.....<.<<.<<<<<...>>>>>.>>...>...>>..>>>>>>>. (((((((....((((((((.....((((((...(.....)...))))..))....)))))).)).((.......((.(((((...))))).)).......))..))))))). RqcH DR variant bound to 50S-peptidyl-tRNA-RqcP RQC complex (rigid body refinement); 5S rRNA 7ope 2 70 3.2 RF00005 URS00002F180C_224308 34255840 0030533 0006412 224308 ggggccuuagcucagggagagcgccugcucacgcaggaggucagcgguucgaucccgcuaggcuccacca <<<<<<<..<<<<.....>>>>.<<<<<....>>>>>.....<<<<<.......>>>>>>>>>>>>.... ((.((((..((((.....)))).(((((....))))).....(((((.......))))))))).)).... RqcH DR variant bound to 50S-peptidyl-tRNA-RqcP RQC complex (rigid body refinement); tRNA-Ala-UGC 7oqb I 23 9.0 34349264 4932 uuacuaagucucauguacuacau ....................... ....................... The U2 part of Saccharomyces cerevisiae spliceosomal pre-A complex (delta BS-A ACT1); ACT1 pre-mRNA (delta-BS-A) 7oqb 2 143 9.0 RF00004 URS000023C730_4932 34349264 0045131 0000348 0005686 4932 guguaguaucuguucuuuucaguguaacaacugaaaugaccucgaggcucauacacauuuuuuggcaggacgggaagaggagacgucgcgacccucgcagagucguucuugacuuggucgcuugauguuucuucuucccguuc .................<<<<<<......>>>>>><<<<<<<..>>>.>>>>................<<<<<<<<<<.<<<<<<<<<<<<.<<.....<<<<<<....>>>>>>>>>>>>..>>>>>>>>.>>>>>>>>>>. ..................(((((......))))).(((((((()))).))))...............(.(((((((((.((((((((((((.((......(((((....))))).))))))..)))))))).))))))))).) The U2 part of Saccharomyces cerevisiae spliceosomal pre-A complex (delta BS-A ACT1); U2 snRNA 7oqc I 63 4.1 34349264 4932 ugguauguucnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn ............................................................... ............................................................... The U1 part of Saccharomyces cerevisiae spliceosomal pre-A complex (delta BS-A ACT1); ACT1 pre-mRNA (delta BS-A),ACT1 pre-mRNA (delta BS-A),ACT1 pre-mRNA (delta BS-A),ACT1 pre-mRNA (delta BS-A),ACT1 pre-mRNA (delta BS-A),ACT1 pre-mRNA (delta BS-A),ACT1 pre-mRNA (delta BS-A),ACT1 pre-mRNA (delta BS-A),ACT1 pre-mRNA (delta BS-A) 7oqc 1 558 4.1 RF00488 URS000012D749_4932 34349264 0030627 0000395 0005685 4932 auacuuaccuuaagauaucagaggagaguccuacugaucaaacaugcgcuuccaauaguagaaggacguuaagcauuuaucauugaacuauaauuguucauugaagucauugaugcaaacuccuuggucacacacacauacggcgcggaaggcguguuugcugacguuuccauucccuuguuucaaucauugguuaaucccuugauuccuuuggggauuuuuggguuaaacugauuuuuggggcccuuuguuucuucugccuggagaaguuugacaccaaauucaaauugguguuaggggagcuggggccuuucaaaagagagcuuuguagaggcauucuuuuugacuacuuuucucuagcgugccauuuuaguuuuugacggcagauucgaaugaacuuaaguuuaugaugaagguauggcuguugagauuauuuggucgggauuguaguuugaagaugugcucuuuugagcagucucaacuuugcucguucccguuaugggaaaaauuuuggaaggucuugguaggaacggguggaucuuauaauuuuugauuuau ...........<<<<.<<<<<<<<<...>>>>.>>>>><<<<<<<<<.<<<<<........<<<<<.<<<..<<<<.<.<<<.<<<<<.......>>>>>.>>>.......>>>>>.>>>>>>>>.....................>>>>>>>>>>>>>><<<.<<<<.<<..<<<<<.<<<<<<<..<<<<<<<.<.<<<..<<<<<<<..>>>>>>>...>>>.>.>>>>>>>..>>>>>>>((.......<<<<<....))>>>>>...<<<<<<<<.......>>>>>>>>.>>>>><<<<<<<<<<<<<<<<<..<<<<...<<.<<<<...<<<<<..<<<<<<..<<<<.......<<<<...<<<<<<<.<<<<<<...<<<<.<<<<<<....>>>>>>..>>>>......>>>>>>>>>>>>>..>>>>.>>>>..>>>>>>.>>>>>..<<<<<....>>>>>.>>>>.>>...>>>>.<<<<<<...>>>>>>...>>>>>>>>>>>>>>>>>.>>>>>>..>>>.>>>>................ ...........((((((((((((((...)))).)))))(((((((((.(((((.[......(((((.(((..(((((...((.((((.........)))).))........))))).)))))))).(].................)))))))))))))))(((.((((.((..(((((((.(((((..(((.(((...(((..((((((....))))))...)))...))).)))..))))).)[[.......(((((....]])))))...((((((((.(....)))))))))))))))((((.(.((((.(((((..((((...((.(((((..(((((..((((((..((((.(...).((((...((.(((..(((.((...((((.((((((....))))))..))))......)).))).))).))..)))).))))..)))))).)))))..(((((....)))))))))).))...)))).((((((...))))))...))))).)))).).)))).))))))..))))))))................ The U1 part of Saccharomyces cerevisiae spliceosomal pre-A complex (delta BS-A ACT1); U1 snRNA 7oqe I 86 5.9 34349264 4932 ugguauguucnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnuuacuaagucucauguacuacau ...................................................................................... ...................................................................................... Saccharomyces cerevisiae spliceosomal pre-A complex (delta BS-A ACT1); ACT1 pre-mRNA (delta BS-A) 7oqe 1 558 5.9 RF00488 URS000012D749_4932 34349264 0030627 0000395 0005685 4932 auacuuaccuuaagauaucagaggagaguccuacugaucaaacaugcgcuuccaauaguagaaggacguuaagcauuuaucauugaacuauaauuguucauugaagucauugaugcaaacuccuuggucacacacacauacggcgcggaaggcguguuugcugacguuuccauucccuuguuucaaucauugguuaaucccuugauuccuuuggggauuuuuggguuaaacugauuuuuggggcccuuuguuucuucugccuggagaaguuugacaccaaauucaaauugguguuaggggagcuggggccuuucaaaagagagcuuuguagaggcauucuuuuugacuacuuuucucuagcgugccauuuuaguuuuugacggcagauucgaaugaacuuaaguuuaugaugaagguauggcuguugagauuauuuggucgggauuguaguuugaagaugugcucuuuugagcagucucaacuuugcucguucccguuaugggaaaaauuuuggaaggucuugguaggaacggguggaucuuauaauuuuugauuuau ...........<<<<.<<<<<<<<<...>>>>.>>>>><<<<<<<<<.<<<<<........<<<<<.<<<..<<<<.<.<<<.<<<<<.......>>>>>.>>>.......>>>>>.>>>>>>>>.....................>>>>>>>>>>>>>><<<.<<<<.<<..<<<<<.<<<<<<<..<<<<<<<.<.<<<..<<<<<<<..>>>>>>>...>>>.>.>>>>>>>..>>>>>>>((.......<<<<<....))>>>>>...<<<<<<<<.......>>>>>>>>.>>>>><<<<<<<<<<<<<<<<<..<<<<...<<.<<<<...<<<<<..<<<<<<..<<<<.......<<<<...<<<<<<<.<<<<<<...<<<<.<<<<<<....>>>>>>..>>>>......>>>>>>>>>>>>>..>>>>.>>>>..>>>>>>.>>>>>..<<<<<....>>>>>.>>>>.>>...>>>>.<<<<<<...>>>>>>...>>>>>>>>>>>>>>>>>.>>>>>>..>>>.>>>>................ ...........((((((((((((((...)))).)))))(((((((((.(((((.[......(((((.(((..(((((...((.((((.........)))).))........))))).)))))))).(].................)))))))))))))))(((.((((.((..(((((((.(((((..(((.(((...(((..((((((....))))))...)))...))).)))..))))).)[[.......(((((....]])))))...((((((((.(....)))))))))))))))((((.(.((((.((((...((((...((.(((((..(((((..((((((..((((.(...).((((...((.(((..(((.((...((((.((((((....))))))..))))......)).))).))).))..)))).))))..)))))).)))))..(((((....)))))))))).))...)))).((((((...))))))....)))).)))).).)))).))))))..))))))))................ Saccharomyces cerevisiae spliceosomal pre-A complex (delta BS-A ACT1); U1 snRNA 7oqe 2 143 5.9 RF00004 URS000023C730_4932 34349264 0045131 0000348 0005686 4932 guguaguaucuguucuuuucaguguaacaacugaaaugaccucgaggcucauacacauuuuuuggcaggacgggaagaggagacgucgcgacccucgcagagucguucuugacuuggucgcuugauguuucuucuucccguuc .................<<<<<<......>>>>>><<<<<<<..>>>.>>>>................<<<<<<<<<<.<<<<<<<<<<<<.<<.....<<<<<<....>>>>>>>>>>>>..>>>>>>>>.>>>>>>>>>>. ..................(((((......))))).(((((((()))).))))...............(.(((((((((.((((((((((((.((......(((((....))))).))))))..)))))))).))))))))).) Saccharomyces cerevisiae spliceosomal pre-A complex (delta BS-A ACT1); U2 snRNA 7ori T 21 3.9 URS00023358C2_2560547 35173159 2560547 aacguuaucuauaacacuacu ..................... ..................... La Crosse virus polymerase at replication late-elongation stage; RNA (5'-R(P*AP*AP*CP*GP*UP*UP*AP*UP*CP*UP*AP*UP*AP*AP*CP*AP*CP*UP*AP*CP*U)-3') 7ori P 12 3.9 URS00023358DB_2560547 35173159 2560547 auagauaacguu ............ ............ La Crosse virus polymerase at replication late-elongation stage; RNA (5'-R(P*AP*UP*AP*GP*AP*UP*AP*AP*CP*GP*UP*U)-3') 7orj H 17 3.9 URS00023358CE_2560547 35173159 2560547 acgagugucguaccaag <<<.....>>>...... .((.....))....... La Crosse virus polymerase at transcription capped RNA cleavage stage; RNA (5'-R(P*AP*CP*GP*AP*GP*UP*GP*UP*CP*GP*UP*AP*CP*CP*AP*AP*G)-3') 7orj T 17 3.9 URS00023358F9_2560547 35173159 2560547 cuugguaguacacuacu ................. ................. La Crosse virus polymerase at transcription capped RNA cleavage stage; RNA (5'-R(P*CP*UP*UP*GP*GP*UP*AP*GP*UP*AP*CP*AP*CP*UP*AP*CP*U)-3') 7ork H 17 3.1 URS00023358CE_11577 35173159 11577 acgagugucguaccaag <<<.....>>>...... .((.....))....... La Crosse virus polymerase in transcription mode with cleaved capped RNA entering the polymerase active site; RNA (5'-R(P*AP*CP*GP*AP*GP*UP*GP*UP*CP*GP*UP*AP*CP*CP*AP*AP*G)-3') 7ork T 18 3.1 URS00023358F9_11577 35173159 11577 acuugguaguacacuacu .................. .................. La Crosse virus polymerase in transcription mode with cleaved capped RNA entering the polymerase active site; RNA (5'-R(P*AP*CP*UP*UP*GP*GP*UP*AP*GP*UP*AP*CP*AP*CP*UP*AP*CP*U)-3') 7orl P 12 3.6 URS00023358C5_11577 35173159 11577 aaugcuauagua ............ ............ La Crosse virus polymerase at transcription initiation stage; RNA (5'-D(*(GTG))-R(P*AP*AP*UP*AP*CP*UP*AP*UP*AP*GP*UP*A)-3') 7orl H 17 3.6 URS00023358CE_11577 35173159 11577 acgagugucguaccaag <<<.....>>>...... .((.....))....... La Crosse virus polymerase at transcription initiation stage; RNA (5'-R(P*AP*CP*GP*AP*GP*UP*GP*UP*CP*GP*UP*AP*CP*CP*AP*AP*G)-3') 7orl T 17 3.6 URS00023358F9_11577 35173159 11577 cuugguaguacacuacu ................. ................. La Crosse virus polymerase at transcription initiation stage; RNA (5'-R(P*CP*UP*UP*GP*GP*UP*AP*GP*UP*AP*CP*AP*CP*UP*AP*CP*U)-3') 7orm T 11 3.3 URS00023358F9_11577 35173159 11577 aguacacuacu ........... ........... La Crosse virus polymerase at transcription early-elongation stage; RNA (5'-R(P*AP*AP*AP*GP*UP*AP*CP*AP*CP*UP*AP*CP*U)-3') 7orm P 15 3.3 URS00023358FC_11577 35173159 11577 uauaauaguagugua ............... ............... La Crosse virus polymerase at transcription early-elongation stage; RNA (5'-R(P*UP*AP*UP*AP*AP*UP*AP*GP*UP*AP*GP*UP*GP*UP*A)-3') 7orn H 17 2.8 URS00023358CE_2560547 35173159 2560547 acgagugucguaccaag <<<.....>>>...... .((.....))....... La Crosse virus polymerase at replication initiation stage; RNA (5'-R(P*AP*CP*GP*AP*GP*UP*GP*UP*CP*GP*UP*AP*CP*CP*AP*AP*G)-3') 7orn T 18 2.8 URS00023358F9_2560547 35173159 2560547 acuugguaguacacuacu .................. .................. La Crosse virus polymerase at replication initiation stage; RNA (5'-R(P*AP*CP*UP*UP*GP*GP*UP*AP*GP*UP*AP*CP*AP*CP*UP*AP*CP*U)-3') 7oro H 14 2.9 URS00023358CE_2560547 35173159 2560547 acgagugucguacc <<<.....>>>... .((.....)).... La Crosse virus polymerase at replication early-elongation stage; RNA (5'-R(P*AP*CP*GP*AP*GP*UP*GP*UP*CP*GP*UP*AP*CP*C)-3') 7oro S 14 2.9 URS00023358F9_2560547 35173159 2560547 gguaguacacuacu .............. .............. La Crosse virus polymerase at replication early-elongation stage; RNA (5'-R(P*GP*GP*UP*AP*GP*UP*AP*CP*AP*CP*UP*AP*CP*U)-3') 7oro T 11 2.9 URS00023358F9_2560547 35173159 2560547 aguacacuacu ........... ........... La Crosse virus polymerase at replication early-elongation stage; RNA (5'-R(P*GP*GP*UP*AP*GP*UP*AP*CP*AP*CP*UP*AP*CP*U)-3') 7osa 25S 3180 3.0 RF02540,RF02543 URS00023119B6_4932 34853469 0003735 0005840 4932 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauagagggugaauaagugggccagugaaauaccacuaccucuauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu .........................<<<<<.....<......>......>>>>>...........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[...........<<.<<<<<<...>>>>>>.>>.............<<<<<<<.<<<<<..<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>..>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<<.....<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<......>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>(><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<..<.<<<<....<.<<.......>>.>..>>>>.>..>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>).<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<...>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<........>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<...............>>>>><<.<<<<<<<<<<<....>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.....<<.....<<<<....>>>>.....>>..>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<<<<<<<<<.....(..<<<<.........)..>>>>..>>>>>>>.>>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<.<..<<<<<......>>>>>..>>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((.(((...))).)).))....)........((((((.((((((...((((((((((.(...({((((......)))))[[(...).(((....}]])))....).))))))..))))...)....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((......((((........)))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((....((.(((((((.....(((....(((..(.((......(.............)....)).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))..........((.))......))....))...(((((........)))))]]((((..(((((((...((((....))).....<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((..........))))))))).).))))))).))))(...)....))))))....)....))))..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((.(....).)))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((..(.(((.((....((...[[..........))..]]...)).)))..)..)))))))....((((.....((((..(((((......)))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......((((((...(.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).)...))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(((((......)))))..)))))...)))....)))).)))))).))))).. Pre-translocation complex of 80 S.cerevisiae ribosome with eEF2 and ligands; 25S rRNA 7osa AB 121 3.0 RF00001 URS000055688D_4932 34853469 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Pre-translocation complex of 80 S.cerevisiae ribosome with eEF2 and ligands; 5S 7osa 58S 158 3.0 RF00002 URS000034CB75_4932 34853469 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(..(((.....]]............).))...)...)))....((.....))(((((((((....)))))))))..................... Pre-translocation complex of 80 S.cerevisiae ribosome with eEF2 and ligands; 5.8S rRNA 7osa 18S 1717 3.0 RF01960,RF01959,RF00177 URS0001A16A88_4932 34853469 0003735 0005840 4932 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...<<<<<.[.((((>>>>><<<<.<<<<<<...<.<...<......<<<.<<<..<<....<<....<<......>>...>>.>>......<<........<<<..<<..<<....<<<............<<......<<.<<<.....>>>.>>......>>........<<<<...>>>>....<<<<<<.....[...........>>>>>>.........<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>..>>>..>....>.>.....<<<<<<<<..............>>>>>.>>>......<<..<...........>..>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>>>>>.........<<<((.....<.<<...<<<.<<....<<<<.<.<<..................>>..>>>>>....<<<..<.............>..>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........<<...<.<<<<<<....].>>>>>>.>..>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>......<<<....>>>..>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..))>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<.<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>..>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<......<<<<<<<.<<...<........>.....>>.>>>>>>>......>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>........ ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((......))...))[))......(((.......(((..((..((....(((........[...(.(.....((.(((.....))).))......))........(((.....)))(.(.((((((......{{(......).)))))).)...).(]((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)....).).....(((((((((..((....))..)))))).)))......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..[......((([[...(.(.((...(((.((....((((.(.((..................))..)))))......(..(.............)..).....(((((.((.......((..((.......)).(((.....)))....))......)).))..)))........((......(((((....}}..))))).....)..)..))...(((..((.((...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)).))...))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..((((((((.(((........)))))))))))..)))...((..]]))...))...].))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..(..(((........)))..)....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((.(((....))).))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...((.((...(..(..............)..)...)).))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}....... Pre-translocation complex of 80 S.cerevisiae ribosome with eEF2 and ligands; 18S rRNA 7osa PSIT 77 3.0 RF00005 URS000057545F_562 34853469 0030533 0006412 562 cgcgggguggagcagcccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(((((.......)))))))))))..... Pre-translocation complex of 80 S.cerevisiae ribosome with eEF2 and ligands; Psite tRNA-Phe 7osm 25S 3162 3.0 RF02540,RF02543 URS00023119B6_4932 34853469 0003735 0005840 4932 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........................<<<<<<.....<......>......>>>>>.>...{.....<<....>>...<<<<......<<.....>>.....>>>>...[[[...........<<.<<<<<<...>>>>>>.>>.............<<<<<<<.<<<<<<<<<<<<<<<<<<<<.....<<<<......>>>>.(.......<<<......)>>>....>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]....}.............................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<.......<<<<<<<<<<<<<<<<<<<<<<<.....<<<<<<<<<....<.<<<<<<....>>>>>>>......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>....>>>>>>>>...>>>>>.>>>>>..<<<<........>>>><<<<<<...<<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<......>...>>>.>>>.>>....>>>>>>.>>>>>>>.<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<.................>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>................................>>....>>...<<<<<........>>>>>))<<<<..<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<<....>>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>.>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<....<....>.....>>>>><<.<<<<<<<<<<....>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<....<<<<<....>>>>.>...>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{.[[[..<<<<<.<<<<<<<<..<<<<<<<<<<<<<<<<...............>>>>>>>>>>>>>>>>...<<<<<.....<<<<..<<<<........>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]...}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<....>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((.(((..((((.((.((..((((((.(....{((((......)))).[[(...).(((....}]]))).....)))))))....)).)).....)))).))).))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((........(((((((((((((((((((((((.......((((((........(.((((..)))).).........)))))).....))))).))))))))))........(((....)))....))))))))....)))).))))).<((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((....((.(((((((.....(((....(((..(.((((...(.(.....).).)))).)..)))..)).).....)))))...((((..(((.(......))))..)))).....))))..)))))))).))..((((.((.((.....)).)).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....))).........(.................)....))....))...(((((........)))))]]((((..(((.((....((((....)))...(.[[((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...)).....))...))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((..)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.((((((((..((.(.((..(((((((...............)))))))..)).).))....((((.....((((...((..........))...........]]...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(..(((((...((.......))...)))))....)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a.))..))).))))).....(((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))........(.((((..((.(.....((.(........(.(((((..).)))).).....))).......((((.(....((((.(..(((......)))..).))))..).))))..............).))..)))).)..(((((....(.......)......(.((.((((((.(((....((((.(..((((((..))))))..)))))...)))....)))).)).))).))))).. Intermediate translocation complex of 80 S.cerevisiae ribosome with eEF2 and ligands; 25S rRNA 7osm AB 121 3.0 RF00001 URS000055688D_4932 34853469 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<<............>>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((.(((...(....)...)))....))....)))))).)).(((((.......(((((..((....)).))))).....))))).))))))))). Intermediate translocation complex of 80 S.cerevisiae ribosome with eEF2 and ligands; 5S rRNA 7osm 58S 158 3.0 RF00002 URS00001BF64E_4932 34853469 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(..(((.....]]............).))...)...)))....((.....))(((((((((....)))))))))..................... Intermediate translocation complex of 80 S.cerevisiae ribosome with eEF2 and ligands; 5.8S rRNA 7osm 18S 1732 3.0 RF01960,RF01959,RF00177 URS000080E2D9_4932 34853469 0003735 0005840 4932 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguucccuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucagagauguauuuauuagauaaaaaugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccgguauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucau ...<<<<<.[.((((>>>>><<<<.<<<<<<...<.<...<......<<<.<<<..<<....<<....<<......>>...>>.>>......<<........<<<..<<..<<....<<<............<<......<<.<<<.....>>>.>>......>>.........<<.....>>.....<<<<<<......[...........>>>>>>.........<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>..>>>..>....>.>.....<<<.<<.<.............>..>>..>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>>.........<<<((.....<.<<...<<<.<<....<<<<<<.<<<<<.........>>>>>.>>>>>>.....<<<<<..........<..........>.........>>>>>....<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........<<...<<<<<<<<....].>>>>>>>>..>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..))>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<........<<........>>..........<<<<<......<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<....<<<<<<.....<<<.<<<<......>>...<<<......>>>...>>.>>>....<<<<..<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>........>>>>.....>>.>>>...>...>>>>>.......>>>>>......>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<......<<<<<<..........................>>>>>>......>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>....... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((......))...))[))......(((.......(((..((..((....(((........[...((......((.(((.....))).))......))..........(.....)..(.(.((((((.........(......).)))))).)...).(]((((..(((.....))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)....).).....(((..(((..............)))...)))......(.(.(...........))..).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..[......((([[...(.(.((...(((.((....((((((...((...........))...)))))).....(((............(.........)............)))....(((((.((.(.....((..((.......)).(((.....)))....))..)...)).))..)))........((....(((.((((......)))).)))...)..)..))...(((..((..(...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)..))...))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..((((((((.((..........))))))))))..)))...((..]]))...))...].))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.(((.((......((........))..........(((((.(....(((..........((..((........))..))........)))...((..((...(..(((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..(.....(((.....((((....)))).......))).....).))..(.((((((.....))))))....)..)))))....))).))......).)).)).....).)))))...))..))).))).(...(((((.(......((.....((..(.((....)).)..))....)).......).)))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...((.(((..........................))).))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}...... Intermediate translocation complex of 80 S.cerevisiae ribosome with eEF2 and ligands; 18S rRNA 7osm ASIT 76 3.0 RF00005 URS00021CC982_4932 34853469 0030533 0006412 4932 gcccggauagcucagucgguagagcaggggauugaagauccccguguccuugguucgauuccgaguccgggcacca .<<<<<<..<<<..........>>>.<<<<<.......>>>>>......<<...........>.>>>>>>>..... .(((((...((.(........).)).((((.........)))).........(........)....)))))..... Intermediate translocation complex of 80 S.cerevisiae ribosome with eEF2 and ligands; PHE tRNA 7osm PSIT 77 3.0 RF00005 URS000057545F_562 34853469 0030533 0006412 562 cgcgggguggagcagcccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>......<<<<.......>>>>.>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(.((...].....)).)))))))..... Intermediate translocation complex of 80 S.cerevisiae ribosome with eEF2 and ligands; FMET tRNA 7ot5 1 2903 2.9 RF02540,RF02541 URS00021ED9BC_562 34994471 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaacccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<<.....>>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<<..<<<.........>>>..>>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<<.<<....>>..>>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<.<..<<<............<<<<<...<.......<<<<<<<<....>>>>>>>>....>.............>>>>>..>.>>..>.>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((((.(.....).))).))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..((...........))..)))........(((......)))..)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((..((....))..)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((....(((.(..........((((..(.(........(..(((....)))..).....).)............)))).))).)....)))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(.(((((....))).)).)....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). CspA-70 cotranslational folding intermediate 1; 23S rRNA 7ot5 2 1534 2.9 RF00177,RF01959,RF01960 URS000081169C_562 34994471 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<......>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>.............>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((........))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((((.......)))))))).....)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((..((....))..)))....(....)...))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... CspA-70 cotranslational folding intermediate 1; 16S rRNA 7ot5 3 120 2.9 RF00001 URS0000049E57_562 34994471 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). CspA-70 cotranslational folding intermediate 1; 5S rRNA 7ot5 z 85 2.9 RF00005 URS0000036214_562 34994471 0030533 0006412 562 gcgggagnggcgaaauuggnagacgcaccagauuuaggnncnggcgccgcaaggngngcgagnncaagncncgccncccgcacca <<<<<<<..<<<...........>>>.<<<<<.......>>>>>.<<<....>>>..<<<<<.......>>>>>>>>>>>>.... (((((((..(((......[....))).((((.........))))..((....))...(((((..]....)))))))))))).... CspA-70 cotranslational folding intermediate 1; tRNA-Leu 7otc a 1533 2.9 RF00177,RF01959,RF01960 URS00023358CD_469008 35500116 0003735 0005840 469008 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauc ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<............>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<.......<<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((.((............))..)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(..(.((((((((.......)))))))).)...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..((.((((....)))).))....(....)...))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Cryo-EM structure of an Escherichia coli 70S ribosome in complex with elongation factor G and the antibiotic Argyrin B; 16S ribosomal RNA 7otc A 2903 2.9 RF02540,RF02541 URS00023358D7_469008 35500116 0003735 0005840 469008 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauuggaccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<<.....>>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<<..>>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<....<....>.....>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<<.<<....>>..>>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<<<<<..<<<......<<<<<<<......>>>>>>>...>>>............>>>>>...>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>.(<<...<<<<<<<...<<<<<<.......>>>>>>.....<<)..(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((.((((.....))))..))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))(...((((...((((((((((((.((.....))))))))))..))))..[))))....)(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((((.(.((..(.(.(.....[...((((...(.(......(((.((((....)))).)))...).)...].........))))).).)..)).).))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Cryo-EM structure of an Escherichia coli 70S ribosome in complex with elongation factor G and the antibiotic Argyrin B; 23S ribosomal RNA 7otc B 120 2.9 RF00001 URS0000049E57_469008 35500116 0003735 0005840 469008 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Cryo-EM structure of an Escherichia coli 70S ribosome in complex with elongation factor G and the antibiotic Argyrin B; 5S ribosomal RNA 7ow7 A 3303 2.4 RF02543 URS0002617716_9606 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagngngaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgggcggaucugaccgucggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucggccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggaggucgccgcgcucuccccccugggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccggggggccacgcgcgcgucccgggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccnucuugnaacncggaccaaggagunuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggccgaggugggaucccgaggccucucgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccnanagauggugancuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauagnggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucggcaguuuuauccgguaaagcgaaugauuagagguaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcngaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacaggaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcaguccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaunuuggugguagunnnaaauauucaaacgagaacuuugaaggccgaaguggngaaggguuccaugngaacagnanuugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggggccgaucgaaagggagucggguucagauccccgaauccggagcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguaccunuauccgcagcaggucuncaaggugaacngccucuggnauguuggaacaanguagguaagggaagucggcaagcnggauccguaacuucnggauaaggauuggcucuaagggcuagccgacuuagaacuggugcggaccaggngaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugccnagugcucugaaugucanagugangaaauucaaugaagcgcggnuaaacggcgggagcucucuuaagguagcnaanugccucnucaucuaauuagugangcgcaugaanggaugancgagnuucccacugunccuaccuacuauccagcgaaaccacngncaagggaacgggcuuggnggaaucagcggngaaagaagacccuguugagcuugacncuagucuggcacggugaagaguuuuucacugacccggugaggcggggggcgcuucuggcgccaagcgcccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacugnggcgguacaccugucaaacgguancgcaggnnuccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucagnacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggangugucagaaaaguuaccacagngauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuungaugucggnucuuccuaucauugugaagcagaauucaccaagcguungaunnuucacccacuaauagggaacgugngcugggnuuagancgucgugagacagguuaguuuuacccuacugaugnuguguuguugccaugguanuccugcucaguacgagaggaaccgcagnuncanacauuugguguaunugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccgguccccgggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuugggucgggguuucguacguagcagagcagcgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<...<<<<...<<<<<<<<.........>>>>.>>>>.....>>>>...<<<<<<<<<.<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>....>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<.<....<<<<<<<<.<<<.....<<<<<<<<<<<..<<<<<<..<<<<.<<.>>>>>>.>>>...>>>>>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<.<<<<<<<<<<<<<<<...<<..<<<....<<<<......<<<<<..>>>>>.......>>>>...>>>........>>>>>>..>>>>>>>>>>>............<<<<<..<<<<<<..>>>>>>.<<<<<<.<<<<.<<<<<<<<<<<.<<<<<<<<<<<<.<<<<....>>>>.>>>>>>>>>>>>.>.>>>>>>>.>>>...>>>>>>>>.>>..<<<<<<<..>>>>>.>>.....>>>>>......>>.>>>>>....>>>>...>>>>>>>>..<<<<........>>>><<<<<<...<<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<..>>>..<<<<<...<<<..<<<.....>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>>.<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<...<<<.<<<<<<<<<...<<<....<<<..<.<<<..>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.........>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<..........>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<................>>>>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<<<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>.................>>....>>>..<<<<<........>>>>>))<<<<.<<<<<..<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<<<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>.>.>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>>....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<...............>>>>><<.<<<<<<<<<..>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<..>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<..>>>>>>>...<<<<<.....<<<<..................<<<<<<<..>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>><<<<....>>>>>>)))].....<<<<<<<..<<<..)))))).>>>>>>>>>>.........>>>>..>>>>>>.......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<....<<<<<.................>>>>>..<<<<....<<<<....<<.<<<<<<.]]]..>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.....<<<<<<..<<..<<<<....<<<........<<<<<.<<<..>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>..............>>>>..>>.>>>>>><<<<<.<.............>..<<.<<<<<<<.<<.....<<<<.<..<<<<..>>>>..>>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..((((((((((.......))))).))))....))))....((((((((((((((((((..({((((......)))))....[[(...).(((....}]])))...).)))))))...))))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....(((((((((.(..((((((.(((((.((.))))))))))...)))).)))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((..(.((((......(((((()))))).......)))).).)))........))))))..)))))))))))............((((((.((((((())))))).((((((.((((.((((((((((..((((((((((((.((((....)))).))))))))))))...))))))).)))...)))))))).))..(((((((..))))).))....)))))).....))).)))))...)))))...)))))))).[((((........))))((((((....(((((((((((((..(((..(((((........))))..)..)))...((....))...(((())))..(((((...(((..(((.....)))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((...(((.((((((((.....((.....((....(((())))....))...))......))))))...(((((((((.(......))))))))))....))))))))))))..))..((((..(.((.....)).)..))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((..........)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((................)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((..(((((((...((.....)).))))))....[[(((.((...(.....(((....)))..................)....))...(((((........)))))]]((((.(((((...((((((......))))))..((((....)))...(...((((((...((((((((((((((((((((((...{{{...)))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).))).))).....((......)).)))).((((.....))))..)))....(((......(.((((..((..(....(.......(((((....(.{..).....)))))((.(((((((((())))..)))))).))(...).......(((((((((.].(...........)...(((((((....((((.....))))......))))))).}.(.(.(((..((((((.....(......(((......)))......)..))))..)))))((((()))))........((..........(((((.......)))))..)..)....).)....)).))))))).)..)))..)))).)...)))))....)).{..((.((.....]}.)).))....(((((..(((.((......((((.(((((...(((((.(((((((((.(((((((())))))))...(((((.....((((..()..............(((((((())))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(..((....((....{..))....)).)(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}.....)))..)))))).......(....(.((((.(...((.......))...).))))...)....)........((((.((((((..(.(...(((......))).....).)..((.(.....).))......)))))..)...))).)......((((((....))).)))...>.))..))).))))).....(.((.(.(..(((..(.(((((......(....).....))))).)(((.....((((....((.(((((((}}}.)))))..)).))...))))....))).((((...((((.............))))...))))..)))...).).)).).....((((((..((..((((.(..(((........(((((.(((()))).))))).......)))...(((...(((....((((.(((((((......)))))))))))...)))...)))...........)..))))..)).))))))(((((....(.......).....((.(((((((.((.....(.((.(..((((()))))..))).)....))....)))).))).))..))))).. EIF6-bound large subunit of the human ribosome; 28S rRNA 7ow7 B 120 2.4 RF00001 URS00000F9D45_9606 0003735 0005840 9606 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. EIF6-bound large subunit of the human ribosome; 5S rRNA 7ow7 C 148 2.4 RF00002 URS0002617739_9606 0003735 0005840 9606 cgacucuuagcggcggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauuncaggacaugaucaucgacacuucgaacgcacuugcggccccgggcccggggcuacgccugucugagcgucgcu .........................................<<<<<<<<<....>>>>.....<.<<<......>>..........>>>..>...>>>....<<....>><<<<<<<<..>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]]..........)))..)...)))....((....))((((((((())))))))).................... EIF6-bound large subunit of the human ribosome; 5.8S ribosomal RNA 7oya 22 1531 3.2 RF01960,RF01959,RF00177 URS0000668FC4_7955 36653451 0003735 0005840 7955 uaccugguugauccugccaguaauauaugcuugucucaaagauuaagccaugcaagucuaagugcacacgagugaaacugcgaauggcucauuaaaucaguuaugguuccuuugaucacuuggauaacuguggcaauuccagagcuaauacaugcgcgccgagacgcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcgcgccggcggcgacgguucauucgaaugucugcccuaucaacuuucgaugguagguccgucgccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccauuuccgacacggagagguagugacgaaaaauaacaaugaauuggaaugagugcaucccaaacccaugggcgaggacccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguaugcuaacguugcugcaguuaaaaagcucguaguuggaucucuacuuugaaaaaauuagaguguucaaggcagggccccccauugaauaccccagcuaggaauaauggaauaggaccccggggccaugaucgagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccggagcgaaagcguuugccaagaacguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccguaaacgaugccgacccgcgauccggcggcguuugacccgccgggcagcguugcgggaaaccacgagucucugggcuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaccucacccggcccggacacggaaaggauugacagauugacggcucuuucucgauucugugggugguggugcauggccguucguaguugguggagcgauuugucugguugauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcggccgucggcguaacuucuuagagggacaaguggcguucagccacgcgagacugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgccacaaugggcggaucaacguguccugcgccgacaggcgcggguaacccguugaaccccgcccgugauggggaccgauugaaacuauuucccgagaacgaggaauucccaguaagcgcaggucaucagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauugagcggcucagugagguccucggaucgcgagaagacgaucgaacucggucguuuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.[.((((>>>>><<.<<<<<<<...<.<<..<......<<<.<<<..<<....<<.............>>.>>......<<........<<<.<<<..<<....<<<.....<<.....<<.<<<.....>>>.>>......>>....<<<......>>>.<<..<<<<<...<......>..>>>>>......>>...<<<<.<<<..>>>>>>>....>>>...>>>>>.>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....<<<....>>>......<<.<<<.........>>>.>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>.>>.........<.<((.....<.<<...<<<.<<....<<<<<.<.......<<...<.......>...<<....>>......>>......>.>>>..>>.........<.<<<..>>>.>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<.>>>>>>>>>>>..>>>....<<..))>>....>>.....>>>.>.>.<<<......<<<......>>>....>>>..)))).]<<<<<.<<<<<<...<...<<<<<...<<.<<<<<<......<<........>>..........<<<<<.<........<........<<..<<........>>..>>.......>....<.<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<.......<<<<..<<<<<<<<<<<.>>>.>>>>>>>>..>>>>........<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>>....>.>>>>>...>>.>>>>.>>......<<<<<<........<.<<<<<<<<....>>>>>>>>....>.........>>>>>>...........<<<...........>>..>..........>>>>>.....<<<<<<<<.......>>>>>>>>.......>....>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<..>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))((.(((((((...(.((..((.....(((.(((..((.....(.............)..))......(((.......(((.(((..((.....(......((.....((..((.....))..))......))..................(...((((...(......)..)))).......)..(.((((...(())..)))))....)....))))).))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.....))).))))).)...)).).....((......))....(.((.(((.........))).))......)..((((([[......((((.....((..]])).......)))).)))))..))))))).))..[......(.([....(.(.((...(((.((....(((((.(.......((..((.......))..((....))......))......).)))..)).........(.(......).)....))...(((.(((..(...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)..)))..))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..((((((((.(((.)))))))))))..))).....(...]).....))...].))))).).(((......((((....))))....)))...]]].].((((.(((((....((..(((((...((..(((((......((........))..........((((..(....(...(........((..(..........)..)).......)..)...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((.(.(...((((..(((((((((((.))).))))))))..))))..).....(((((.....)))))......).)))....))).))).....).))))).....)..))))...)).)))..))..(...((((((........(.((((((((....))))))))....).........))))))...........(.(...........)...).......)..))))).....((((((((.......))))))))......)).....)))))))).)...(.(..((.(..((((.((..(.((((((((.(((..((.(.((...((()))...)).).))..))).)))))))))..)).))))...).))...)..)..((..(((((....)))))..))}........ Cryo-EM structure of the 1 hpf zebrafish embryo 80S ribosome; 18S rRNA 7oya 51 3321 3.2 RF02543,RF02540,RF02540 URS00023359DF_7955 36653451 0003735 0005840 7955 cacgaccucagcucagacgagaagacccgcugaauuuaagcauauuacuaagcggaggaaaagaaaccaaccgggauucccccaguagcggcgagcgaagagggaaaaguccagcgccgaauccccgccccagggcgagggaccuguggcguacggagggccgccucucucggcgcgggggccaaaguccuucugauggaggcuuagcccgcggacggugugaggccggugucggcccccgccccgccggggugcgguuccucccggagucggguuguuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagcggacaaguaccgugagggaaaguugaaaagaacuuugaagagagaguucaacagggcgugaaaccguuaagagguaaacggguggggaccgcaccguccgcccgguggauucagcccggcggggcggggucggcccguccgguggcucccuucgcucccgcgggggguugacgcccgggcgaaggcucggccgccgccgggugcauuuccgccgcgguggagcgccgcgaccggcuccgguucggcuuggaagggucagggggcgaagguuuuacagcgcccucccgccccgacuucgccgcuugcucuccggggccgcgggcccucucugcccucccucugcggggacggggucccccgcccccggcguggcgcgacagggguggacuguccucaguccgcugcgccgcgccgcccagggcgggggacccacguucgggcgcccgagguccgcggcgacgccggccucccacccgacccgucuugaaacacggaccaaggaguccaacgcgcgcgcgagucagaggguggcucgcgagccccugcggcgcaaugaaggugagggugggauccccccgccccggcggggggcgcaccaccggcccgccucgcgacccuccggggggcagguggaguuggagcgcgcgcgauggcacccgaaagauggugaacuaugccugggcagggcgaagccaggggaaacucugguggaggcccgccgcgguccugacgugcaaaucggucguccgaccugggcauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucgccgaucaagcaguuuuauccgguaaagccaaugacuagaggcaccuauucucaaacuuuaaauggguaagaggcccggcucgcuggcgcuggagccgggcguggaaugcgacgcgccuagugggccauuuuugguaagcagaacuggugcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccauaaaagguguugguugauauagacagcccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgacggcagcugcaagccucgacgaguaggagggccgccgcgguggcgccgaagcccagggcgcgggcccggguggagccgccgcgggcgcagaucuuggugguaguagcaaauauucaaacgagagcuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggugagccgguccuaagggacgggccuacgccguucggaggggagggccccgcucgaccgaaagggagucggguccagauccccgagcccggagcggcggagacgggcgccgcgaggcgcccagugcggugacgcaaacgaacccggagaugccggcgggugccccgggaaagaguucucuuuucuuugugaagggcagggcgcccuggaacggguucgccccgagagaggggcccgcgcccuggaaagcgccgcgcuucuggcggcguccggugagcucucgucggcccuugaaaauccgggggagaagguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcguguuggaacaaggcagaguaagggaagucggcaagucagauccguaacuucgggauaaggauuggcucuaagggcugauagcagccagcuuagaacugucgcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccucggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaacgaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccugcuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuagucuggcccugugaagagacuuuccucacuuacccggugaggcgggcuucuggcgucaagcgccccgcggggcgcgacccgccccggggacagcgucagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucaggggggacagaaaccucccguagagcagaagggcaaaagcucgcuugaucuugauuuucaguaugaguacggaccgcgaaagcggggccucacgauccuuccggcuuuugggguuuuaagcgggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaacagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugugagccguuguugcaauaguaaucccgcucaguacgagaggaaccgcggguucagacauuugguucgugcgcuuggcugaggagccacuggcgcgaagccaccaucugcgggauuaugacugaacgccucuaagucagaaucccgccuaaaagcaacgauaagcgccgucggaucuccgauaggccccggguaaccgggaccccggcgcggagagccauucgugacaggagcggcuagaacgagcgccgcccccucuuccagugacgcaccgcauguuuguggggaacccggugcuuaaaugacucguagacgaccugauucugggucggggugucgugcguggcagagcagcgcugcgauccauugaaagucagcccucgauccaaguuuug .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..<<<..<<<<<...<<<<<<<<<..>>>>>.>>>>.....>>>>>..<<<<<<<<<<...<<<.<..<.<<<<<<<.....<<<<......>>>>.....((......<<<.....))>>>.....>>>>>>>...>..>.>>>..>>>>>.>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<.......<<<<...<<<<....<<<<<<<<<.......<.<.<.<<<<.<..........<..<.......>..>........>..>>>>..>..>.>....>>>>>>>>>.....>>>>....>>>>.....<...<.<.<.<<<.<<...<....<<..<<...<<<<.<<....<.>.....>>.>>>>....>>.........>>.>.....>>..>>>.>.>........<.<<...<<<<.<..>.>>>>...<<<<<..<<.<.<.<<<<<<...<<<<......<<<<<<<....>>>>>>>.>.>>>.>>>>>>......>.>.>>>>>>>.......>>.>.......>....>.......>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<.<<<<<<<<<..<<<...<<<<.........>>>>....>>>...<<....>>...<<<<<...<<<<<<<<....>>>>>>>>....>>>>><<<<<<<<<.....<........>...>>>>>>.>>>...>>>>>>>>>.>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<.........<<<.<<<<<<<<<...<<<....<<<....<<<..>>>....>>>..>.>>...>>>>>>>...<<<<<<<<<..........>>>>>>>>>....>>>>>>>.>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<.>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<........>>>>>>>>>....>>>>>>.<.<<<<<<<<<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>............<...>........>>....>>>..<<<<<........>>>>>))<<<<....<<<<....<<<<<<<....>>>>>>>...<<<....>>>...<...<<<<<<...<<<<<<<<<.<<<<<<<.<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>.>.>>.>>>>>>>>>.........>>>>>>...>..........>..>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<....<<<<<.<<<.<<.........<.....<<<<<.....<..>......>>>>><<.<<<<<<<<<<<....>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>>.<<<<<.......>>>>>.........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<...<<<<.<<<...>>>.>>>>...<<<<<.....<<<..............<<<<<<<..>>>>>>>...>>>..>>>>>......>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>>.<<<....>>>.>>)))].....<<<<<<<..<<<..)))))).>>>>>>>>>>.........>>>>..>>>>>>.......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.......<<<<<<<<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<<<<<<<<.]]]..>>>>..>>>>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>>>>>>>>.<<<<<<...<...<<<<....<<..........<<<<<..>>>>>.........>>...<<<.<..<<...<<<..........>>>.........>>...>.>>>..............>>>>....>>>>>>>.<<<...<.............>....<<<<<<<<<<..<.....<<<<....<<<<..>>>>...>>>>....>.....>>>>.>>>>>>...>>>. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..((((((((((..))))).))))....))))....((((((((.........(....((((((((..({((((......)))))....[[(...).(((....}]])))...).))))))).......).......))).)))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))...............((((....))))..................................((((((((..(((.......(.((......(.....((((((((.......(...(..(((.(.........(.(...........).).......)..)))...)....)....))))))))......).......)).).....(.......(...(..(........((..(......((..................)).......).........)).......)...)...)..........(......((((......))))..((((((..((.(.(.((((((...(((.......((.((((....)))).))...))).))))))......).).))))))).)........)............).......)))...)))))))).[((((........))))((((((....(((.(((((((((..(((...(((...........)))....)))...((....))...(((((...((((((((....))))))))....)))))(((((((((..................)))))).)))...))))))))).)))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((........)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((..........((.((((((((....(((....(((..(.(((..))).)..)))..)).)....))))))...(((((((((..........)))))))))....)))).)).)))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.....{.(.)...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((........)))))))))....)))))).(.((((((((((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...((..(.(((....)))....).......(...)........))....))...(((((........)))))]]((((....((......(((((((....)))))))..((((....)))...(...((((((...(((((((((.(((((((.((((((..{{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....(((((((.......))))))))))).).)).)))))))))(...)....))))))...)).............)).)))).)))..)).....((......)).)))).((((.....))))..)))....((((....(((((.(((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((....)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...(......((((....))))......).)))))..)))))(((((.........)))))........((.(......).(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.(((((((.(.((((.((.(..))).))))...(((((.....((((.............(((((((())))))))..))))..)))))....).)))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(.(((.(((((....{..)))).)))))(((....))).))]]].......((((((...((..]]]]]].)).))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))....))..))).))))).......((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}}.)))))..)).))...))))...)))).((((...((((.....}.......))))...))))..)))...).))))))...(.......(...((.....((.(........(((((..)))))........)))...(((.(..(..(..((..........).)..).......)...).)))...............))....)....)...(((...(..(.......)..)....((((((((((..(.....((((.(..((((()))))..)))))....).....)))).))))))...))). Cryo-EM structure of the 1 hpf zebrafish embryo 80S ribosome; 28S rRNA 7oya 71 120 3.2 RF00001 URS00023359DD_7955 36653451 0003735 0005840 7955 gcuuacggccauaccacccuggaaaugcccgaucucaucugaacucggaaguaaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccaggugcuguaagcua <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((....(((((((...(....)...))))..)))...)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. Cryo-EM structure of the 1 hpf zebrafish embryo 80S ribosome; 5S rRNA 7oya 81 158 3.2 RF00002 URS00023359DC_7955 36653451 0003735 0005840 7955 aacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaacuaaugugaauugcaggacacacauugaucaucgaccuuucgaacgcacauugcggccccggguccaucccggggccacgccugucugagggucgcc ........................................<<<<<<.<......>>>.....(.<<<.......>...............>>>..)...>>>....<<.....>><<<<<<<<<.....>>>>>>>>>.................... ........................................((((((.[[.....))).....(.(((......]]...............)))..)...)))....((.....))((((((((((..).))))))))).................... Cryo-EM structure of the 1 hpf zebrafish embryo 80S ribosome; 5.8S rRNA 7oyb 22 1502 2.4 RF01960,RF01959,RF00177 URS0000668FC4_7955 36653451 0003735 0005840 7955 uaccugguugauccugccaguaauauaugcuugucucaaagauuaagccaugcaagucuaagugcacacgagugaaacugcgaauggcucauuaaaucaguuaugguuccuuugaucacuuggauaacuguggcaauuccagagcuaauacaugcgccgcgugcauuuaucaguggugacucuagauaacgccgaucgcgcgcgcggcgacgguucauucgaaugucugcccuaucaacuuucgaugguagguccgucgccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccauuuccgacacggagagguagugacgaaaaauaacaauuuggaaugagugcaucccaaacccaugggcgaggacccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguaugcuaacguugcugcaguuaaaaagcucguaguuggaucucuuuacuuugaaaaaauuagaguguucaaggcagggccccccauugaauaccccagcuaggaauaauggaauaggaccccggggccaugaucgagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccggagcgaaagcguuugccaagaacguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccguaaacgaugccgacccgcgauccggcggcguuugacccgccgggcagcguugcgggaaaccacgagucucugggcuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaccucacccggcccggacaauugacagauucucgauucugugggugguggugcauggccguucguaguugguggagcgauuugucugguugauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcggccggucggcguaacuucuuagagggacaaguggcguucagccacgcgagacugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgccacaaugggcggaucaacguguccugcgccgacaggcgcggguaacccguugaaccccgcccgugauggggaccgauugaaacuauuucccgagaacgaggaauucccaguaagcgcaggucaucagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauugagcggcucagugagguccucggaucggcgccgagaagacgaucgaacucggucguuuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.[.((((>>>>><<.<<<<<<<...<.<<..<......<<<.<<<..<<....<<.............>>.>>......<<........<<<.<<<..<<....<..<....<<.....<<.<<<.....>>>.>>......>>..............<<<<<...<......>..>>>>>......<<<..<....>.>>>..>...>...>>>>>.>>>.<<<....<<<.....<<<<<<<.......>>>>>>>.>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>..>>>..>...>>.>.....<<...>>......<<.<<<.........>>>.>>.........<.<<<((......<<<......<<..))>>........>>>.>>>.>..>>>>>>>.>>.........<.<((.....<.<<...<<<.<<.....<<<<<<.<.......<<...<.......>...<<...>>.......>>......>.>>>..>>>..........<<<..>>>......>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>.>.>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<.>>>>>>>>>>>..>>>....<<..))>>....>>.....>>>.>.>.<<<......<<<......>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<....<<............<<........>>..........<<.<<...........<<.....>>............<.<..<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<..<<<<<..>>>.>>..>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>.>>......>>.>>.........>.>.......<<<<<<........<.<<<<<<<<....>>>>>>>>....>.........>>>>>>............<<..........>>..............>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<..>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>.........<<<<<<<<<<..>>>>>>>>>>......... ...((((....[[[..))))((.(((((((...(.((..((.....(((.(((..((...........(..)......[))......(((.......(((..((..(.....(.(......(.....((.(((.....))).))......)..............(.((((...(......)..)))))....(.(.(.........).))...).)....)))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((....(((.]...)))..)))).)...)).)......(..)......(....(((.........))).........)...(((([[....(.((.(.....((..]]))........))))))).)..))))))).))..[......(.([[...(.(.((...(((.((.....((((((.........((..((.......))................))........)))..)))........(.((....)).)....))....((..((..(...((((..(((.((((((((...((........))......)))))))).))).......((....))...))))..)..))...))...)))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.(((.))))))))).)..)))....((..]]))....))...].))))).).(((......((((....))))....)))...]]]..(((((.(((((((..((..(((((.....(..((.........(........)...........((.(...................................(..(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(.(.(.(...((((..((......((....)).......))..))))..).....(((((.....)))))......).).)....))).))).....).))).).......)..))......)).).....(.....(((.........(.((((............))))....)..........)))..............((..........))...........)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(.((..((((.(((..((((.((...((((..))))...)).))))..))).))))..)))..)).))))...).))...)..)..(((((((((....)))))))))}........ Cryo-EM structure of the 6 hpf zebrafish embryo 80S ribosome; 18S rRNA 7oyb 51 3263 2.4 RF02543,RF02540,RF02540 URS00023359DF_7955 36653451 0003735 0005840 7955 cacgaccucagcucagacgagaagacccgcugaauuuaagcauauuacuaagcggaggaaaagaaaccaaccgggauucccccaguagcggcgagcgaagagggaaaaguccagcgccgaauccccgccccagggcgagggaccuguggcguacggagggccgccucucucggcgcgggggccaaaguccuucugauggaggcuuagcccgcggacggugugaggccggugucggcccccgccccgccggggugcgguuccucccggagucggguuguuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagcggacaaguaccgugagggaaaguugaaaagaacuuugaagagagaguucaacagggcgugaaaccguuaagagguaaacggguggggaccgcccgcccgguggauucagcccggcggggcggggucggcccguccgguggcucccuucgcgggguugacgcccgggcgaaggcucggccgccgccgggugcauuuccgccgcgguggagcgccgcgaccggcuccgguucggcuuggaagggucagggggcgaagguuuuacagcgcccucccgccccgacgccgcuugcucuccggggccgcgggcccucucugcccucccucugcggggacggggucccccgcccccggcguggcgcgacagggguggacuguccucaguccgcugcgccgcgccgcgggcgggggacccacguucgggcgcccgagguccgcggcgacgccggccucccacccgacccgucuugaaacacggaccaaggaguccaacgcgcgcgcgagucagaggguggcucgcgagccccugcggcgcaaugaaggugagggugggauccccccgccccggcggggggcgcaccaccggcccgccucgcgacccuccggggggcagguggaguuggagcgcgcgcgauggcacccgaaagauggugaacuaugccugggcagggcgaagccaggggaaacucugguggaggcccgccgcgguccugacgugcaaaucggucguccgaccugggcauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucgccgaucaagcaguuuuauccgguaaagccaaugacuagaggcaccuauucucaaacuuuaaauggguaagaggcccggcucgcuggcgcuggagccgggcguggaaugcgacgcgccuagugggccauuuuugguaagcagaacuggugcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccauaaaagguguugguugauauagacagcccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgacggcagcugcaagccucgacgaguaggagggccgccgcgguggcgccgaagcccagggcgcgggcccggguggagccgccgcgggcgcagaucuuggugguaguagcaaauauucaaacgagagcuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggugagccgguccuaagggacgggccuacgccguucggaggggagggccccgcucgaccgaaagggagucggguccagauccccgagcccggagcggcggagacgggcggcccagugcggugacgcaaacgaacccggagaugccggcgggugccccgggaaagaguucucuuuucuuugugaagggcagggcgcccuggaacggguucgccccgagagaggggcccgcgcccuggaaagcgccgcgcugcggcguccggugagcucucgucggcccuugaaaauccgggggagaagguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcguguuggaacaaggcagaguaagggaagucggcaagucagauccguaacuucgggauaaggauuggcucuaagggcugagcagccagcuuagaacugucgcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccucggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaacgaagcgcggguaaacggcggucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccugcuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuagucuggcccugugaagccucacuuacccggugaggcggguucuggcgucaagcgccccgcggggcgcgacccgccccggggacagcgucagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucaggggggacagaaaccucccguagagcagaagggcaaaagcucgcuugaucuugauuuucaguaugaguacggaccgcgaaagcggggccucacgauccuuccggcuuuugggguuuuaagcgggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaacagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugugagccguuguugcaauaguaaucccgcucaguacgagaggaaccgcggguucagacauuugguucgugcgcuuggcugaggagccacuggcgcgaagccaccaucugcgggauuaugacugaacgccucuaagucagaaucccgccuaaaagcaacgauagcgccgucggaucuccgauaggccccggguaaccgggaccccggcgcggagagccauucgugacaggagcggcuagaacgagcgccgcccccucuuccagugacgcaccgcauguuuguggggaacccggugcuuaaaugacucguagacgaccugauucugggucggggugucgugcguggcagagcagcgcugcgauccauugaaagucagcccucgauccaaguuuug .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..<<<..<<<<<...<<<<<<<<<..>>>>>.>>>>.....>>>>>..<<<<<<<<<....<<<.<..<<<<<<<<<.....<<<<......>>>>.....((......<<<.....))>>>.....>>>>>>>>..>..>.>>>...>>>>.>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<......>>>..................................<<<<<<<<..<<<..<<<<.<<<<<<....<<<<<<<<<.....<.<.<.<.<<<<<<...<<....<<<...>>>.....>>.>>>>>>..>..>.>.>..>>>>>>>>>.....>>>>>>..>>>>.....<...<.<.<.<<<.<<...<....<<..<<...<<<<.<<............>>.>>>>....>>......>>.>.....>>..>>>.>.>........<.<<...<<<<.<..>.>>>>..<<<<<<..<<.<.<.<<<<<<...<<<<......<<<<<<<....>>>>>>>.>.>>>.>>>>>>...>.>.>>>>>>>.>.....>>.>.......>....>.......>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<.<<<<<<<<<..<<<...<<<<.........>>>>....>>>...<<....>>...<<<<<...<<<<<<<<....>>>>>>>>....>>>>><<<<<<<<<.....<........>...>>>>>>.>>>...>>>>>>>>>.>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<.........<<<.<<<<<<<<<...<<<....<<<..<.<<<..>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<..........>>>>>>>>>....>>>>>>>.>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<......<..........<<<.<<<<<<<<<<.......<.>...>>>>>>>>>>>>>..........))).>....>>>>>..>>>...>>>>>>><<<<<<.<<<........>>>>>>>>>....>>>>>>.<.<<<<<<<<<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<.<...>.>......>>....>>...<<<<<........>>>>>))<<<<....<<.<....<<<<.>>>>...<<<....>>>...<...<<<<<<...<<<<<<<<<.<<<<<<<.<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<...>>>>>>>>>>>.>.>>.>>>>>>>>>.........>>>>>>...>..........>...>>.>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<....<<<<<.<<<.<<.........<.....<<<<<....<....>.....>>>>><<.<<<<<<<<<<<..>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>>............<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<...<<<<....>>>>...<<<<<.....<<<.............<<<<<<<..>>>>>>>...>>>..>>>>>......>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>>.<<<....>>>.>>)))].....<<<<<<<..<<<..)))))).>>>>>>>>>>.........>>>>..>>>>>>.......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<.<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>..>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.......<<<<<<<<..<<<....<<<<<.................>>>>>..<<<<....<<<<....<<<<<<<<<<]]].>>>>>..>>>>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>>>>>>>>.<<<<<...<<.<<<<<....<<..........<<<<<..>>>>>.........>>...<<<....<<.<<<<<..........>>>>>.......>>.....>>>..............>>>>>.>>.>>>>>..<<<...<.............>....<<<<<<<<<<..<.....<<<<....<<<<..>>>>...>>>>....>.....>>>>.>>>>>>...>>>. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..((((((((((..))))).))))....))))....((((((((.........(..(.((((((((..({((((......)))))....[[(...).(((....}]])))...).)))))))...)...).......))).)))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((....((.((((.......((((((((.....(.(...(.((((.(..(.(....(.(...).).....)).).))))..)....).)..))))))))........))))..)).......(.......(...(...........((..(......((..(............)..)).......)......))...........)...)..........(.(....(((........)))..((((((..((.(.(.((((((...(((.......((.((((....)))).))...))).))))))...).).))))))).)......).)............).......)))...)))))))).[((((........))))((((((....(((.(((((((((..(((...(((...........)))....)))...((....))...(((((...((((((((....))))))))....)))))(((((((((.....(........)...)))))).)))...))))))))).)))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((..........((.((((((((....(((....(((..(.(((..))).)..)))..)).)....))))))...(((((((((..........)))))))))....)))).)).)))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.....{.(.)...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((........)))))))))....)))))).(.((((((((((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...((..(.(((....)))....).....(.(....))......))....))...(((((........)))))]]((((....((......((((.))))..((((....)))...(...((((((...(((((((((.(((((((.((((((..{{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....(((((((...))))))))))).).)).)))))))))(...)....))))))...)).............)).)))).)))..)).....((......)).)))).((((.....))))..)))....((((....(((((.(((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((..)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...(......((((....))))......).)))))..)))))(())........((.(......).(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.(((((((.(.((((.().))))...(((((.....((((............(((((((())))))))..))))..)))))....).)))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].......((((((...((..]]]]]].)).))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).))))).......((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}}.)))))..)).))...))))...)))).((((...((((.....}.......))))...))))..)))...).)))))).((...(..(....((.....((.(........(((((..)))))........)))...(((.(..(..(((((..........)))))........)...).)))...............))....))...))..(((...(..(.......)..)....((((((((((..(.....((((.(..((((()))))..)))))....).....)))).))))))...))). Cryo-EM structure of the 6 hpf zebrafish embryo 80S ribosome; 28S rRNA 7oyb 71 120 2.4 RF00001 URS00023359DD_7955 36653451 0003735 0005840 7955 gcuuacggccauaccacccuggaaaugcccgaucucaucugaacucggaaguaaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccaggugcuguaagcua <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((....(((((((...(....)...))))..)))...)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. Cryo-EM structure of the 6 hpf zebrafish embryo 80S ribosome; 5S rRNA 7oyb 81 150 2.4 RF00002 URS00023359DC_7955 36653451 0003735 0005840 7955 aacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaacuaaugugaauugcaggacagaucaucgaccuuucgaacgcacauugcggccccggguaucccggggccacgccugucugagggucgcc ........................................<<<<<<<((....>>>>.......<<<......)).........>>>......>>>....<<.....>><<<<<<<<<...>>>>>>>>>.................... ........................................((((((.[[....[)))...].(.(((......]].........)))..)...)))....((.....))(((((((((...))))))))).................... Cryo-EM structure of the 6 hpf zebrafish embryo 80S ribosome; 5.8S rRNA 7oyc 22 1495 2.4 RF01960,RF02542,RF01959,RF00177 URS0002349D5A_8355 36653451 0003735 0005840 8355 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcacguguaaguacgcacggagugaaacugcgaauggcucauuaaaucaguuaugguuccuuugaucacuuggauaacugugguaauucuagagcuaauacauggcauuuaucaguggugacucuagauaaccgccgaucgcacgcacggcgacgauacauucggaugucugcccuaucaacuuucgaugguacuuucugcgccuaccauggugaccacggguaacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacgcggggagguagugacgaaaaauaacaauuuggaaugaguacacuuuaaauccuuuaacgaggaucuauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuuguuuacuuugaaaaaauuagaguguuccaagcaggccgccuggauacuucagcuaggaauaauggaauaggacuccggggccaugauuaagagggacggccgggggcauucguauugugccgcuagaggugaaauucuuggaccggcgcaagacgaaccaaagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgacuagcgauccggcggcguuagacccgccgagcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacaauugacagauuucucgauucugugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacuccuccaugcuaacuaguuacgcgaccggucggcguaacuucuuagagggacaaguggcguucagccacacgagaucgagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugaacggaucagcguguccugcgccgacaggugcggguaacccgcugaaccccguucgugauagggaucggggauugcaauuauuucccaugaacgaggaauucccaguaagugcgggucauaagcucgcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugagguccucggaucggcgccgagaagacgaucaaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<.........<<<.<<<..<<....<.....<<...>>....>.>>......<<........<<<.<<<..<<....<<<<<...<<.....<<.<<<.....>>>.>>......>>..<<..<<<<<...<......>..>>>>>..>>...<<<<.<<..>>>>>>.>>>.>>...>>>>>.>>>.<<<....<<<....<<<<<<...........>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>......>>.>.....<<<.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<......<<<<<<.<.......<<...<.......>.<<<<.>>>>...>>......>.>>>..>>>........<.<<<..>>>.>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>.>.>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<.>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<......>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<......<....<<......>>..........>...<<.<<<..<<<<<<<<.....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<..<<...<<<<..<<<<<<<<<<<..>>>.>>>>>>>>..>>>>..>>....<<<<<.....>>>>>........>>>.....>>.>>>...>.>>>>>>>.......>>>>>...>>.>>>>.>>>.....<<<<<<........<.<<<<<<<<....>>>>>>>>....>.........>>>>>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((..((....((....((...))...))[))......(((.......(((.(((..(.....(((.....((.....((.(((.....))).))......))..(...(((((...(......)..)))))...).(.((((.((..)))))))..).))....)))).))).(((....(((....((((((...........)))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).).....(((.)))....(.(.(.(...........))..)......)..((((([[....(.(((......((..]]))........)))))))))..)))))).)))..[......(.([[...(.(.((...(((.((......((((((.(.......((..((.......))....()......))......).)))..)))........(.(((..))).)....))....((..(...(...((((..(((.((((((((...((........))......)))))))).))).......((....))...))))..)...)...))...)))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((..((..(.((((((.(((.))))))))).)..))....((..]]))...))...].))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....((...((.(..).)).........))...(..(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(.(...(...((((..((....(((((..))).))....))..))))..).....(((((.....)))))........).)....))).))).....).))).).....).)))))...)).)))).))).(...(.(((.........(.((((.((......)).))))....)..........))).)......(.....(((((..........))))).....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..((((.((...((((()))))...)).))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}........ Cryo-EM structure of the Xenopus egg 80S ribosome; 18S rRNA 7oyc 51 3245 2.4 RF02543 URS0002349D5D_8355 36653451 0003735 0005840 8355 ucagaccucagaucagacgcggcgacccgcugaauuuaagcauauuacuaagcggaggaaaagaaacuaaccaggauucccccaguaacggcgagugaagagggaagagcccagcgccgaauccccgcccgcgggcgcgggacguguggcguacgggagaccggacccccccggcgcgcgggggcccaaguccuucugaucgaggcccagcccgcggacgguguuaggccgguggcggcccccggcgcggcgggacccggucuccucggagucggguuguuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagcggacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgugcgguccgcccggaggauucaacccggcggguccgccggccggaccgggccacucggcgggacgcggcccgggcggccccggcgcccgcagggcgcauuuccuccgcggcggugcgccgcgaccggcuccgggccggcugggaaggcccagggguucaggggaguuacagcccccccccaggcagcaucgccgucgcccggggccgaggguccgcggccuccuccccaagggggaaggggccccccgcucccggcgcggcgcggacugcccccagugcgcgccgcgccgccgaggcgggagggcccgcgggagccgccagggguccgcggcgaugucggugucccacccgacccgucuugaaacacggaccaaggagucuaacgcgcgcgcgagucggagggacgcgaaacccuguggcgcaaugaaggugagggccggggcgccccggcugaggugggaucccgccgcgccggcgggcgcaccaccggcccgucucgcccgccccgucggggagguggagcgugagcgcgcgcgauaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucguccgucgcaguuuuauccgguaaagcgaaugauuagagguaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcuuggagccgggcguggaaugcgagcacgccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcgccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcgcugggcuaggccgcgacgaguaggagggccgccgcggugggcgcggaagccccgggcgagggcccggguggagccgccgcgggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccuaagagaugggcgagcgccguucggaagggcggccgaucgaaagggagucggguucagauccccgaacccggagcggagacgggcguccagugcggcgacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggccgcccuggaauggguucgccccgagagaggggcccgcgccuuggaaagcgucgcgggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuagaacaauguagguaagggaagucggcaagucagauccguaacuucgggauaaggauuggcucuaagggcuggcagcugacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgaggcggguguugacgcgaugugauuucugcccagugcucugagucaaagugaagaaauucaaugaagcgcggguaaacggcaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuaucuagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucugcaacugugaaguuucacuuacccggugaggcggggggcuucuggacccaagcgcccggcgggcgcgacccgcuccgaggacaguggcagguggggaguuugacuggggcgguacaccugucaaaccguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguaugaauacagaccgugaaagcggggccucacgauccuucugacuuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguugucgcaauaguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaauccccccuaaacgugacgauaagcgccgcggagccucggucggccucggauagccggcgcgccggcgggcagagccgcucgccucgggaccggagcgcggacgaaagggggccgccucucucccggagcgcaccgcacguucguggggaaccuggugcuaaaucauucguagacgaccugauucugggucaggguuucgugcguagcagagcagcgcugcgaucuauugaaagucaucccuugagccauuuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..<<<..<<<<<...<<<<<<<<<..>>>>>.>>>>.....>>>>>..<<<<<<<<<......<<<<.<<<<<<<<<<<<.....<<<<......>>>>.....((......<<<.....))>>>.....>>>>>>>>.>>>>.>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<......>>>..................................<<<<<<<<..<<<.......<<<<.<<<<<<.....<<<.<<<<<<...<.<<.......<<.....<<.....>>.....>>........>>.>..>>>>>>.>>>......>>>>>>..>>>>.....<...<.<.<.<<<.<<.<.<....<<........<<<<..................>>>>...........>>.>.>...>>.>>>.>.>.......<<<<<.<<<<<<....>>>>>>.<<<<<<<<<<<<<..<<<<<<<<<<<<.<<<<....>>>>.>>>>>>>>>>>>....>>>>>>.>>>>>>.>....>>>>>......>....>.......>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<.<<<<<<<<<..<<<..<<<<........>>>>..>>>...<<....>>...<<<<<<<....>>>>>>>..<<<<<...<<<<<<<...>>>>>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>.>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<.......<<<.<<<<<<<<<...<<<....<<<....<<<..>>>....>>>..>>.>...>>>>>>>...<<<<<<<<<.........>>>>>>>>>....>>>>>>>>>..>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<..>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<..........>>>>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..................>>....>>...<<<<<........>>>>>))<<<<.<<<<....<<<..>>>...<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<..<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<..>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>..>>>.>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<...............>>>>><<.<<<<<<<<<<<.>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<...<<..<<<<<<.<.<<.....<<<<....>>>>.....>>.>>>>>..>>>>.......<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<.<<.<<<<<..>>>>>...<.<<<.....<<<<................<<<<<<<.>>>>>>>..>>>>..>>>.>....>>.>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>><<<<....>>>>>>)))].....<<<<<<<...<<..)))))).>>.>>>>>>>.........>>>>..>>>>>>.......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<.<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>..>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<<<..<<<....<<<<<.................>>>>>..<<<<....<<<<....<<.<<<<<<<]]].>>>>>..>>.>>...>>>>...>>>>.<<<....<<<<<...........>>>>>....>>>..>>>...>>>>>>>>.<<<<<<<..<..<<<.....<<<........<<<<<<..>>>>>>.......>>>...<<<...<<<<...<<<.<<<<...........>>>>>>>..>>>>...>>>...............>>>..>.>>>>>>><<<...<.............>....<<<.<<<<<<.<<.....<<<<....<<<<..>>>>...>>>>....>>....>>>.>>>.>>>.>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..((((((((((()))))).))))....))))....((((((((((.....((((.((((.(((((((...({((((......)))))....[[(...).(((....}]]))).....)))))))..)))).))))..))))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((......(((((..(((.(.....(((.(((((....(.((.....(.((..(..(...()..).)...)).)......)).)...))))).)))......).)))...)))))....(.......(...(.((.(......(..........(((..................))).............)...)...)).)...).........(((((((((.((....)).))).((.((((((((((..((((((((.(((.((((....)))).))).))))))))....)))))).)))).).)..).)))))...........).......)))...)))))))).[((((........))))((((((....(((.(((((((((..(((...(((........)))...)))...((....))...((((((......))))))..(((((...(((((((...)))))))....))))).(((((((((..(.((...).).).))))))).))....))))))))).)))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((........)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((........((.((((((((....(((....(((..(.(((..))).)..)))..)).)....))))))...(((((((((.........)))))))))....)))).))))..)))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.....{.(())...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((..........)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...((....(((....))).........(.)......))....))...(((((........)))))]]((((.((((....((.().))..((((....)))...(...((((((...(((((((((((((((((((((((..{{{..))))))....(((((.((((..((((.....(((.....))).....))))))))..))))).....(((((((..))))))))))).).))))))))))))(...)....))))))...)).........)..))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((.)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(.(......((((....))))......).)))))..)))))......((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((.((.(((((())))))...(.(((.....((((................(((((((.)))))))..))))..))).)....)).))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(.(((.(((((....{..)))).)))))(((....))).))]]].......((((((...((..]]]]]].)).))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))....))..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}}.)))))..)).))...))))...)))).((((...((((.....}.......))))...))))..)))...).)))))).((((((...(...((.....((..........(((((()))))).........))...(((.(..(((...(((.((((.(......)..)))))))..)))..).)))...............))...)..))))))(((...(..(.......)..)....(((.((((((.((.....((((.(..((((()))))..)))))....))....))).))).))).))).. Cryo-EM structure of the Xenopus egg 80S ribosome; 28S rRNA 7oyc 71 119 2.4 RF00001 URS00004611F3_8355 36653451 0003735 0005840 8355 gccuacggccacaccacccugaaagugccugaucucgucugaucucagaagcgauacagggucgggccugguuaguaccuggaugggagaccgccugggaauaccaggugucguaggcu <<<<<<<<.....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>.>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))). Cryo-EM structure of the Xenopus egg 80S ribosome; 5S rRNA 7oyc 81 147 2.4 RF00002 URS0002349D5C_8355 36653451 0003735 0005840 8355 gacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuagugugaauugcaggacagaucaucgacacuucgaacgcaccuugcggccccgggcccggggccacgccugucugagggucgcu ........................................<<<<<<.<<.....>>>.....(.<<<......>>.........>>>..)...>>>....<<.....>><<<<<<<<<>>>>>>>>>.................... ........................................((((((.[[....[)))...].(.(((......]].........)))..)...)))....((.....))((((((((())))))))).................... Cryo-EM structure of the Xenopus egg 80S ribosome; 5.8S rRNA 7oyd 5 3358 2.3 RF02543 URS00026813AD_9986 36653451 0003735 0005840 9986 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggaaauguggcguacggaagacccacccggcgccggggggcccaaguccuucugaucgaggccgcccguggacggugugagnccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaanggaaaguugaaaagaacuuugaagngagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggaucaacccggcggcggccggccgugccggggggcggaucuggaccgccccccggccggcgaccggccgccgccgggcgcauuuccaccgggcggugcgccgcgaccggcuccgggacggcunggaaggcccggcggggaagguggcccggccggguguuacagcccgcccccggcagcagcgacucgccgaaucccggggccgagggagcgagacccgugccgccgcgcucuccccccugggggggccgggccaccccucccacggcgcgaccgcggggcggacuguccagugcgccccgggcgggucgcgccgucgggcccggggggccacgcgcgagcgcacggggucggcggcgaugucggcuacccacccgacccnucuugnaacncggaccaaggagucuaacacgngcgcgagucgggggcuacgaaagccgccguggcgcaaugaaggugaaggccgggccgaggugggaucccgaggccucuccaguccgccgagggngcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuagnacccnanagauggugancuaugccugggcagggcgaagccagaggaaacucuggugnagguccguagcgguccugacgugcgaaucgnucguccgaccuggguauagnggcgaaagacuaaucgaaccaucuaguagcuggnucccuccaaaguuucccucaggauagcuggcgcucucgcaguuuuauccgguaaagcgaaugauuagagguaccuauucucaaacuuuaaaungguaagaagcccggcucgcugguguggagccgggcguggaaugcgagugccuagugggccacnuuuggnaagcngaacuggcgcuncgggaugaaccgaacgccggguuaangcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggaugguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggaugncgcuggagcgucgggcccauacccggccgucgcuggcagucggcagagcgagaaagagagugggcggacgcuacgccgcgacgaguaggagggccgcugcgnugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguagunnnaaauauucaaacganaacuuugaaggccgaaguggngaaggguuccaugugaacagnanuugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgcucagccgaucgaaagggagucgnguucagauccccgaauccggagcggagaugggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcggcguccggugagcucucgcuggcccuugaaaauccggggnagaggguguaaaucucgcnccgggccguaccnauauccgcagcaggucuncaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagcnggauccguaacuucgggauaaggauuggcucuaagggccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugccnagugcucugagucanagugnagaaauucaaugaagcgcggguaaacggcgggaguaaugacucucuuaagguagcnaanugccucnucaucuaauuagugacgcgcaugaauggaugancgagauucccacugucccuaccuacuauccagcgaaaccacngncaagggaacgngcuuggnggaaucagcngngaaagaaganccuguugagcuugacucuagucuggcacggugaauucacugacccggngaggcgggggggccucgcuucuggcgccaancgcccgcgggcgcgacccgcuccggggacagugccaggugggnaguuugacngnggcgguacaccugucaaacgguancgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucungauuuucagnacgaauacagaccgugaaagcggggccunacgauccuucugaccuuuungguuuuaagcaggannugucagaaaaguuaccacagggauaacuggcuuguggcggccangcguucauagcgacgucgcuuuuugauccuungaugucggcucuuccuaucauugunaagcagaauunaccaagcguungauuguucacccacuaauagggaacgugngcuggnnuuagancgucgugagacagnuuaguuuuacccuncugaugnuguguuguugccaugguaauccugcncaguacgagaggaaccgcagguncanacauuugguguaunugcuuggcugaggagccaauggggcgaagcuacnaucugugggauuaugacunaacgccucuaagucagaaucccgcccaggcggaacgauagcgccggagccucgguuggccucggauagccggccgguncngagagcccuucgucccgggaaacgggccggaaaggggccgcgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..[[[..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>>..<<<<<<<<<.<<<<<<..<.<<<<<<<<....<<<<......>>>>...((......<<<.....))>>>...>.>>>>>>>...>.>>>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<....<<<<<<<<<<<<<<<<<<.<<<<<<<<<<<<.<<..>>>>>>>>>>>>>>>>>>...>>>>>>>>>>>>>>......>>>.>>>>>>>>...<<<<<<<<<<<<<<<<<<.<<<<...<<..<<<.<<..<<<......<<<<<..>>>>>.......>>>..>>..>>>.........>>>>>>...>>>>>>>>>>.....<<.......>>......<<<<<<.<<<<<<..>>>>>>...<.<<..<<<.<<<<<<<<<<<<<<.<<<<<<<.<<<<..>>>>.>>>>>>..>..>>>>>>>>>>>.>>>...>>>>>.>.......>>>>>>.....>>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<.....>>>>.....>>>...<<....>>...<<<<.>>>>..<<<<<...<<<..<<.....(((.[[..>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<..<<<.<<<<<<<<<...<<<....<<<..<.<<<..>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<......<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>....>>>>>..>>>...>>>>>>><<<<<<.<<<....................]].)))...........>>>>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<...>>......>>....>>>..<<<<<........>>>>>))<<<<.<<<<<..<<<<..>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..{{{..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<..>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<...............>>>>><<.<<<<<<......>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<...<<.....<<<<....>>>>.....>>..>>>>..>>>>><<<<<<....>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<<.<<<<..>>>>...<<<<<.....<<<<..<<..>>..............<<<<<<..>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>>.<<<....>>>.>>)))]......((((((..(((..>>>>>>.)))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]].....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<.}}}..>>>>..>>.>>...>>>>...>>>><<<<....<<<<<...........>>>>>....>>>>.>>>...>.>>>>>>.<<<<<<<..<<<<....<<<........<<<<..>>>>.......>>>...<<<..<<<<......<<<.......>>>....>>>>..>>>..............>>>>..>.>>>>>>.<<<<<.<.............>....<<.<<<<<<<.<<.....<<<<....<<<..>>>...>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..(((((((((((.....)))))).))))....))))....(((((((((.((((((.(..((((((((..({((((......)))))..[[(...).(((....}]])))...).)))))))...).))))))...)))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((....((((((((((.(((((((.(.((((((((((.((())))))))))))).)))))...))).))))))))))......))).))))))))...(((((((((((((((((((((((...((..((..((..(((......((((....)))).......)))..))...)).........))))))..))))))))))).....(......{..)......((((((.((((((()))))))...(.((..(((.((((((((((.(((.(...(((.((((..)))).))).....)..))).))))))).)))...))))).).......)))))).....))).)))))...)))))...)))))))).[((((........))))((((((..(.(((((((((((((..(((..((((.......)))..)..)))...((....))...((((.))))..(((((...(((..((.(...[[[.[[[)))..)))....))))).(((((((((.((((......))))))))))).))....)))))))))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)<)))...(((..((.((........)))).)))....))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((.(((((((..(((.((((((((....(((....(((..(.(((..))).)..)))..)).)....))))))...(((((((((.(......))))))))))....))))))))))))..))..((((..((((.....))))..))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.......(((((..((...((.........))...))......(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((........}.........].]].]]]...........)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...(...(.(((....))).....)....((.())).......)....))...(((((........)))))]]((((.(((((...((....))..((((....)))...(...((((((...(((((((((((((((((((((((..{{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....(((((..))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((..)..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((...(......(((......)))......)..))))..)))))(((((......)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.(((((((((.((((()))))...(((((.....((((..(....)..............((((((()))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(..((..((((....{..))))..)).)(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......(....(.((((((...((.......))...))))))...)....)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))....))..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}}.)))))..)).))...))))...)))).((((...((((.............))))...))))..)))...).)))))).((((((...((((....(((.........(((())))........)))...(((..(((.........................)))..)))..............))))....)))))).(((((.(..(.......)..)....((.(((((((.((.....((((.(..(((())))..)))))....))....)))).))).))..))))).. Cryo-EM structure of a rabbit 80S ribosome with zebrafish Dap1b; 28S rRNA 7oyd 8 144 2.3 RF00002 URS00004B2C76_9986 36653451 0003735 0005840 9986 gacucuuagcggnggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcagguugaucaucgacacuucgaacgcacugcggccccgggcccggggcuacgccugucugagcgucgcu ........................................<<<<<<<<<....>>>>.....<.<<<......>>........>>>..>...>>>....<<...>><<<<<<<<..>>>>>>>>.................... ........................................((((((.[[.....))).....(.(((......]]........)))..)...)))....((...))((((((((())))))))).................... Cryo-EM structure of a rabbit 80S ribosome with zebrafish Dap1b; 5.8S rRNA 7oyd 9 1698 2.3 RF01960,RF02542,RF01959,RF00177 URS00026813AF_9986 36653451 0003735 0005840 9986 uaccugguugauccugccaguagcaunugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuauggunccuunggucgcucguacuuggauaacugugguanuucuagngcuaauanaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgcccggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcnaauuacccacucccgacccgggganguagugangaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugagucnacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauancguauauuaaaguugcugcaguunaaaagcucguaguungaucuugggagcggccguccccugcucggcgccggcccgaagcguuuacuuugaaaaaanuagaguguucaaagcaggccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagancgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccacnaggaguggagccugcggcuuaauuugacncaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggcnguucuuaguugguggagcgauuugucugguuaauucngauaacgaacgagacucuggcaugcuaacuaguuacgcgaccccggucggcguaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauunagucccugcccuuuguacacaccgnccgucgnuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggugcccuggcggagcgcugagaagacggucgaacuugncuaucuagaggaaguaaaagucgnancaagguuucnguaggugnnccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<....<<....<<<<..........<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<<<....>>>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<<.>>>>>>>>..>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>...<<....>>.....>>>>>>.........<<<....<<<.....>>>..>>>..>...>>.>.....<<<<<<<<<.<<<....>>>..>>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<....<<<.<<<..>>>.>>><<<<<<<.<<..>>>>>>.>>>.<<<<<<.<.......<<...<.......>.<<<<.>>>>...>>......>.>>>..>>>........<.<<.<<<<<<<...............>>>>>>>.>>.>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<<....>>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<......<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<..>>>>.>>>>>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.......>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<.<<<<<<<<<..>>>>>>>>>...>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..((....(((.....(([...((.....((.(((.....))).))......))......)).((((...(.(((......))).)...))))((..(((((...(......)..)))))......)).(]((((.((((.)))))))))...)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).).....(((((((((..((....))...)))))).)))....(.((..(...........)..))......)..((((([[......((((.....((..]])).......)))).)))))..)))))).)))..[......(.([[...(.(.((...(((..(....(((..((()))..))).((((((.((())))))).))..((((((.(.......((..((.......)).(((.)))....))......).)))..)))........(.((.(((((((...............))))))).)).)....)....(((.(((..(...((((..((..((((((((...((........))......))))))))..)).......((....))...))))..)..)))..))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.(((((....))))))))))).)..)))...((..]]))...))...].))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((..(...(((((.....(..((..((........))..))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((...(...((((..((((((((((((..)))).))))))))..))))..).....(((((.....)))))........)))....))).))).....).))))).....).)))))...)).)))).))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....((.(((((.......))))).))......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..((((.((...(((((((((((((((..))))))))).).)))))...)).))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}........ Cryo-EM structure of a rabbit 80S ribosome with zebrafish Dap1b; 18S rRNA 7oyd K 119 2.3 RF00001 URS000002B0D5_9986 36653451 0003735 0005840 9986 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))). Cryo-EM structure of a rabbit 80S ribosome with zebrafish Dap1b; 5S rRNA 7oyg P 10 5.5 URS00021ED95E_2697049 2697049 cuacgcagug .......... .......... Dimeric form of SARS-CoV-2 RNA-dependent RNA polymerase; RNA (5'-R(P*CP*UP*AP*CP*GP*CP*AP*GP*UP*G)-3') 7oyg T 12 5.5 URS00021ED994_2697049 2697049 ugcacugcguag ............ ............ Dimeric form of SARS-CoV-2 RNA-dependent RNA polymerase; RNA (5'-R(P*UP*GP*CP*AP*CP*UP*GP*CP*GP*UP*AP*G)-3') 7oyg G 10 5.5 URS00021ED95E_2697049 2697049 cuacgcagug .......... .......... Dimeric form of SARS-CoV-2 RNA-dependent RNA polymerase; RNA (5'-R(P*CP*UP*AP*CP*GP*CP*AP*GP*UP*G)-3') 7oyg H 12 5.5 URS00021ED994_2697049 2697049 ugcacugcguag ............ ............ Dimeric form of SARS-CoV-2 RNA-dependent RNA polymerase; RNA (5'-R(P*UP*GP*CP*AP*CP*UP*GP*CP*GP*UP*AP*G)-3') 7ozu P 10 3.3 URS0002311A0E_32630 34381216 32630 cuacgcagua .......... .......... SARS-CoV-2 RdRp with Molnupiravir/ NHC in the template strand base-paired with A; Product RNA 7ozu T 12 3.3 URS00023119F9_32630 34381216 32630 ggnacugcguag ............ ............ SARS-CoV-2 RdRp with Molnupiravir/ NHC in the template strand base-paired with A; Template RNA 7ozv P 10 3.2 URS00023119E0_32630 34381216 32630 cuacgcagug .......... .......... SARS-CoV-2 RdRp with Molnupiravir/ NHC in the template strand base-paired with G; Product RNA 7ozv T 12 3.2 URS00023119F9_32630 34381216 32630 ggnacugcguag ............ ............ SARS-CoV-2 RdRp with Molnupiravir/ NHC in the template strand base-paired with G; Template RNA 7p3k A 1519 2.9 RF00177,RF01959,RF01960 URS00023119D3_83333 34403461 0003735 0005840 83333 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugccggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<......>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<.>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<.......<<<....>>>......>>>>...<.<<<<<.......<<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<..>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((((((......)))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....(((.((.)).))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((((())))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((..(((.(((....))).)))...(......)..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....))))))))..)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Cryo-EM structure of 70S ribosome stalled with TnaC peptide (control); 16S rRNA 7p3k a 2753 2.9 RF02540,RF02541 URS0002311999_83333 34403461 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagcgucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcgcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<<..>>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<..>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<..>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.......<<<<<<.<<....>>..>>>>>>.......>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<..>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((((((.....))))).))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(())...)))..))))).))...........]]].)...))))))))))...)))))))((((((((()))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((())))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Cryo-EM structure of 70S ribosome stalled with TnaC peptide (control); 23S rRNA 7p3k b 119 2.9 RF00001 URS000080E133_83333 34403461 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>> ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))) Cryo-EM structure of 70S ribosome stalled with TnaC peptide (control); 5S rRNA 7p3k V 75 2.9 RF00005 URS00023119E1_83333 34403461 0030533 0006412 83333 cggcacguagcgcagcgguagcgcaccgucauggggugucgggggucggagguucaaauccucucgugccgacca <<<<<<<..<<<<.......>>>>.<<<.<<.....>>.>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((....[..)))).(((.(.......).))).....(((((..]....)))))))))))).... Cryo-EM structure of 70S ribosome stalled with TnaC peptide (control); tRNA 7p48 5 73 2.9 RF00005 URS00002ECE5B_1280 35137182 0030533 0006412 1280 gcgggauggagcaguucgguagcucgucgggcucauaacccgaaggucggugguucaaauccgccucccgcaa <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>.. ((((((..((((......[..)))).(((((.......))))).....(((((..]....))))))))))).. Staphylococcus aureus ribosome in complex with Sal(B); P-site tRNA 7p48 A 2661 2.9 RF02540,RF02541,RF00002 URS0002311A04_1280 35137182 0003735 0005840 1280 uuaaguuauuaagggcgcacgguggaugccuuggcacuagaagccgaugaaggacguuacuaacgacgauaugcuuuggggagcuguaaguaagcuuugauccagagauuuccgaauggggaaacccagcaugaguuaugucauguuaucgauaugugaauacauagcauaucagaaggcacacccggagaacugaaacaucuuaguacccggaggaagagaaagaaaauucgauucccuuaguagcggcgagcgaaaugggaagagcccaaaccaacaagcuugcuuguugggguuguaggacaggaguuacaaaggacgacauuagacgaaucaucuggaaagaugaaucaaagaagguaauaauccuguagucgaaaauguugucucucuuccugaguacgacggagcacgugaaauuccgucggaaucugggaggaccaucuccuaaggcuaaauacucucuagugaccgauagugaaccaguaccgugagggaaaggugaaaagcaccccggaaggggagugaaauagaaccugaaaccgugugcuuacaaguagucagagcccguuaaugggugauggcgugccuuuuguagaaugaaccggcgaguuacgauuugaugcaagguuaagcaguaaauguggagccguagcgaaagcgagucugaauagggcguuuaguauuuggucguagacccgaaaccaggugaucuacccuuggucagguugaaguucagguaacacugaauggaggaccgaaccgacuuacguugaaaagugagcggaugaacugaggguagcggagaaauuccaaucgaaccuggagauagcugguucucuccgaaauagcuuuagggcuagccucaagugaugauuauuggagguagagcacuguuuggauucagacaaacuccgaaugccaauuaauuuaacuugggagucagaacaugggugauaagguccguguucgaaagggaaacagcccagaccaccagcuaaggccccaaaauauauguuaaguggaaaaggauguggcacugcgccgaaaauguaccggggcuaaacauauuaccgaagcuguggauuguccggacaaugguaggagagcguucuaagggcguugaagcaugaucguaaggacauguggagcgcuuagaagugagaaugccggugugaguagcgaaagacgggugagaaucccguccaccgauugacuaagguuuccagaggaaggcucguccgcucuggguuagucggguccuaagcugaggccgacaggcguaggcgauggauaacagguugauauuccuguaccaccuauaucgauggggggacgcaguaggauaggcgaagcgugcgauuggauugcacgucuaagcaguaaggcugaguauuaggcaaauccgguacucgggcugagcugugauggggagaucgagucguugauuucacacugccgagaaaagccucuagauauaggugcccguaccgcaaaccgacacagguagucaagaugagaauucuaaggugagcgagcgaacucucguuaaggaacucggcaaaaugaccccguaacuucgggagaaggggugcucuuuaggguuaacgcccagaagagccgcagugaauaggcccaagcgacuguuuaucaaaaacacaggucucugcuaaaccguaaggugauguauaggggcugacgccugcccggugcuggaagguuaagaggagugguuagcgcgaagcuacgaaucgaagccccaguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgacccgcacgaaaggcguaacgauuugggcacugucucaacgagagacucggugaaaucauaguaccugugaagaugcagguuacccgcgacaggacggaaagaccccguggagcuuuacuguagccugauauugaaauucguggcuuucuaacccgcaccacuuaucguggugggagacagugucaggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcucaaagguucccucagaaugguuggaaaucauucauagaguguaaaggcauaagggagcuugacugcgagaccuacaagucgagcagggucgaaagacggacuuagugauccggugguuccgcauggaagggccaucgcucaacggauaaaagcuaccccggggauaacaggcuuaucucccccaagaguucacaucgacggggagguuuggcaccucgaugucggcucaucgcauccuggggcuguagucggucccaaggguugggcuguucgcccauuaaagcgguacgcgagcuggguucagaacgucgugagacaguucggucccuauccgucgugggcguaggaaauuugagaggagcuguccuuaaccgggauggacauaccucugguguaccaguugucgugccaacggcauagcuggguagcuauguguggacgggauaagugcugaaagcaucuaagcaugaagccccccucaagaugagauuucccaacuucgguuauaagaucccucaaagaugaugagguuaauagguucgagguggaagcauggugacauguggagcugacgaauacuaaucgaucgaagacuuaau <<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<.[...((.>>>.....<<<<<<<..<<<))...].>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<<<<<<<<.........>>>>>>>.>>.>>.....<<<<......<<....>>.......>>>>...........<<....>>..<<<<<......<<.....>>.....>>>>>..(((....<<<<<<<<....>>>>>>>>......<<<<..<<<<.......<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>>>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<......>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<.<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>.>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<...<<<<<<<<<.....<<<...<<<<<<<..>>>>>>>..>>.>.....>>>>>.>>>>..>>>>>>>.>>..<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<.(((.....<<<<<<...........<<..<<<<..>>>>.>>...........))).....>>>>>>..>>...>>>>>>><<<<<<..>>>>>>....>>>>>><.<<<<<<<.<<......<<<<<.<<....>>.>>>>>...>>.>>>>>>>..>.....>>>>>><......<<....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<.<.<<<...<<<....>>>...>>>..>>>...<<<<<........>>>>>))<<<<<<.<<<...<<<<....<<<<..<<<..<<<<<.<<<<<<...(((...>>>>>><<..<<<<<..<<<.<<<<<<..<<.....>>.>>>>>>..>>>..>>>>>...>>...<..>...>>>>>...>>>...>>>>.........>>>>..>>>.>>>>>>>>>>..>>.....<<......>>>>>>>.<<<.......>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<<.<<<<....>>>>.>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<..<<...<<<<<<.<..>..>>>>>>...>>..>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<<.<<<<.<<..>>.>>>>....<<.<<<<<<.....>>>>>>>>.....>>>>>>>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<.....>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.)))>>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>.<<<....>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>. ((((((......(((((((((......(((..(((((((((.(((......((((((.[[..[[[)))...].((((((...(((]]..]].)))......))))))...)))....(((....)))(((((((......))))))).(((((((((.........))))))).)).))....(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...((((((((....))))))))....[.((((..((((........(((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))))))).)))))))))....(((((((...{.......)))))))....].(((((}.[[[[)))))..)))......)..))))))).))...............((....))....))......(..((((....))))............))......))))))))).......((((..((((..[...))))..)))).<.(.(........).).((((((....(((((((.(((((..(((...(((.....)))...)))...((....))..((((.....)))).....))))).)))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)<)))...(((.(((((........))))))))..).))))))))).(.(((....[)))...).]))))))......).))..((((((....(.(((....))).)(.(((((((...(((((((((.....(((....((((((()))))))...)).).....))))).))))..)))))))..)..((((((((((......))))))))))....(((......)))...((((.(((...((..[[...(.((((((.....(.....((..((((..)))).))...........]]..)...))))))).))...)))))))((((((()))))))....))))))(((((((((.((......(((((.((....))])))))...)).))))))).)).....))))))(......((....((((((.......))))))((((....(((...((...((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((((.((...((((....(((((.(((..(((((.((((((....{{...))))))((..(((((..(((((((((((.((.....))))))))).))))..)))))...))...(())...)))))...)))..)))))(..).....))))..)).)))))))))))..)).....((......))..))).(((.......)))..))))..((((....((((((((.((..(....(.......(((((....(.[..).....)))))(((((((.((.(....).)).)))))))(...).......(((((((((.>.(...........)...(((((((.....(((....))).......))))))).]((((..((..(((((((..(((...((...(((((..(())...)))))...))...))))))))..)))).(((((.........))))).........(..........(((((.......)))))..).......))))...)).))))))).)..))).)))))))).)))))).....)..[..(((((.....>].)))))..((((((((.(((.((......((((.((((((..(((((.(((((((((.((((.((())).))))....((.((((((.....)))))))).....)))))))))..)))))..(((......[)))((((((..........]))))))([.(...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).).]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(.(((.(.((((((...((.......))...))))))...))))...).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....))))))).(((((...((((...(((((((((((.}}.))))))..)))))...)))).)))))...(((....((((.............))))....))).))))..]....))))))).(((....)))....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))....)))))). Staphylococcus aureus ribosome in complex with Sal(B); 23S rRNA 7p48 B 113 2.9 RF00001 URS0000062A7E_1280 35137182 0003735 0005840 1280 cuggugacuauagcaaggaggucacaccuguucccaugccgaacacagaaguuaagcuccuuagcgucgaugguagucgaacuuacguuccgcuagaguagaacguugccagg <<<<<<<<....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<......<<<.<<<<....>>>>.>>>......>>..>>>>>>>>. (((((.((....((((((((.....((((((...(.....)...))))..))....)))))).)).((.......((.((((....)))).)).......))..)).))))). Staphylococcus aureus ribosome in complex with Sal(B); 5S rRNA 7p48 a 1479 2.9 RF00177,RF01959,RF01960 URS0002311997_1280 35137182 0003735 0005840 1280 auggagaguuugauccuggcucaggaugaacgcuggcggcgugccuaauacaugcaagucgagcgaacggacugauguuagcggcggacgggugaguaacacguggauaaccuaccuauaagacugggauaacuucgggaaaccggagcuaauaccggauaauauuuugacgcaugguucaaaagugaaagacggcugucacuuauagauggauccgcgcugcauuagcuaguugguaagguaacggcuuaccaaggcaacgaugcauagccgaccugagagggugaucggccacacuggaacugagacacgguccagacuccuacgggaggcagcaguagggaaucuuccgcaaugggcgaaagccugacggagcaacgccgcgugagugaugaaggucuucggaucguaaaacucuguuauuagggaagaacauauguguaaguaacugugcacaucuugacgguaccuaaucagaaagccacggcuaacuacgugccagcagccgcgguaauacguagguggcaagcguuauccggaauuauugggcguaaagcgcgcguaggcgguuuuuuaagucugaugugaaagcccacggcucaaccguggagggucauuggaaacuggaaaacuugagugcagaagaggaaaguggaauuccauguguagcggugaaaugcgcagagauauggaggaacaccaguggcgaaggcgacuuucuggucuguaacugacgcugaugugcgaaagcguggggaucaaacaggauuagauacccugguaguccacgccguaaacgaugagugcuaaguguuaggggggccccuuagugcugcagcuaacgcauuaagcacuccgccuggggaguacgaccgcaagguugaaacucaaaggaauugacggggacccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaaaucuugacauccucuagagauagaggacagguggugcaugguugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuuaagcuuaguugccaucaugggcacucuaaguugacugccggugacaaaccggaggaagguggggaugacgucaaaucaucaugccccuuaugauuugggcuacacacgugcuacaauggacaauacaaagggcagcgaaaccgcgaggucaagcaaaucccauaaaguuguucucaguucggauuguagucugcaacucgacuacaugaagcuggaaucgcuaguaaucguagaucagcaugcuacggugaauacguucccgggucuuguacacaccgcccgucacaccacgagaguuuguaacacccgaagccgguggaguaaccuaggagcuagccgucgaaggugggacaaaugauuggggugaagucguaacaagguagccguaucggaaggugcggcuggaucaccuccuu .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<...<<......>>...>>>>>......<<........<<<<<<<..<<...<<<<<<<.<<<<.....<<<<<<....>>>>>>......>>>>......<<<.<.........>.>>>.......<..<.>..>..>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>..<<<<<<<<.......<.<<<<<<<........>>>>>>>.>........>>>>>>...>>.<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<<..<<<.<<<<<<<.<<<<<<<<<.......<<<<<<.....>>>>>>.....>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>..>>>>>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<.>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<.<<<<....>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<..<<<<<<<..<<<..<..>>>>...>>>>>>>.....<<<<<.....>>>>>.........>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<..<<<<....<.<<<<..<<<..<<..>>.>>>.>>>>.>...>>>>..>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............. .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((...(........)...)))))......(((.......(((((((..((...(((((((.((((.....((((((....))))))......))))......(((..(.......)..))).......(..(.)..)..)))))))..))))))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...((((......))).))))).)).))))))..((((......((((....)))).....))))..(.((((((...(.....(((((((........))))))).....)....))))))....).(((.([[[...(((((.....((.]]])).......)))))).)))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))...).)))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((....(...((((.........))))...).))))))......{...((((((..((((((((((((.))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..(((((((((.......((........))...........((((((......((.(((......))).))..((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(.(((((..(.(..(..)).)...))))).)..(..((((.......)))).....)..)))).....).).)))...)).)))))....)))))).....).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(.....((((((........)))))).....)..)..))))).....(.(((.(.........).))).)......))...)))))))))).))..(.(..((.(.((((.(((..((((((..((((....(.((((..(((..((())).))).)))).)...))))..))))))..))).))))..).))...)..)..(((((((((....)))))))))}............ Staphylococcus aureus ribosome in complex with Sal(B); 16S rRNA 7p6z 3 2879 3.5 RF02540,RF02541 URS0000AB9B3C_272634 36171285 0003735 0005840 272634 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<<<......<<<<.<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>....<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((....<<<<<<....>>>>>>......<<<<<<<<<.....<<...<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>..>>..>>>>>..>>>>.....<<<<<<<<.......>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<....>>>>.............}....>>>>>>.>>>>.......<<<<..<<<<......>>>>..>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<...<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<.<<........>>.>>>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<....<<<<<<<<<<.....<<<....<<..<<<<<...<.<<<<.....>>>>..>...>>>>>..>>..>>.>.....>>>>>>>>>>...>>>>>>.>>..<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((...<<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<.........>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>...........))).....>>>>>>>>>>...>>>>>>><<<<<<......>>>>>>....>>>>>><.<<<<<<<<<<......<<<<<.<<....>>.>>>>>...>>>>>>>>>>..>.....>>>>>>.......<<...<<<<<<.......>>>>>><<<<....<<<<<.<<<..<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<<...<<<<..<<<<..<<<<<<<<<....(((...>>>>><<..<<<<<..<<<<<<<<<<<.<<.....>>>>>>>>>....>>>>..>>>>>...>><..<<.......>>...>>>>>....>>>>...>>>>........>>>>.>.>>.....>>>>>>>>>>>>>>>.>>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<<...<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<......>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<..<<..<<<<<<<.<<....>>..>>>>>>>..>>..>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<.<<<<.....>>>>.>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>>>>>>>>...........<<<<<........>>>>>..<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<<.<<.<<<.<<<<..<<<...........<<<<<..<<<......<<<<<<<......>>>>>>>...>>>.............>>>>>..>>>..>>>>.>>>.>>...<<<..<<<<<.....>>>>>.>>>....>>>>>>>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<<....<<<..<<<<<<<...............>>>>>>><<<<<<...<<<<...<<<<<<<<<<<.)))>>>>>>..>>>>>...>>>>.>>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>........>>>>>>>....<..>......<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((.(((((.....(((..(((((((((((((......((((((....[[[.)))....(((((((...(((]]]....)))......)))))).).)))....(((....)))((((((((....))))))))..((((((((.........))))))))..))....((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...(((((......)))))......(((((((((.....((...((((((((((.(((...(((((......)))))[[......(((.....]])))...)))...))))))))))..))..)))))..)))))....(((((((((.[..).))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((....))))............)).....))))).)))).....(.((((..((((..[...))))..)))).<.(.(........).).((((((....(((((((((((((....((...(((.....)))...))....((....))..((((.....))))....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)<)))...(((.((.((........)).)))))..).))))))))).(.((.......))...)..))))))......).))..((((((....(((((....))))).(((((((....((((((.(((.....(((....(((.(((((...(.((.(.....).))..)...))))).)))..)).).....))).))))))...)))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(((((((.....(.....((..(..(((((((.....{..((((.(.(..(((.........)))..).).....(...((......)).).))))....)))))))..).))...........]]].)...))))))))))...)))))))(((((((....)))))))....))))))(.(((((..(((......(((((.((....))])))))...)))..)))))..).....)))))).......((...((((((.......))))))((((....(((...((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((((((((((...(((((...((((..(.((..(((((((((.....{{...)))))((..(((((..((((..(((((.((.....)))))))......))))..)))))...))(..((.......))...)))))....)).)...))))(..)....)))))..)).....))))))))))))))).))).....((......))..))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.[..).....)))))((((((......))))))(...).......((((((.((.>.((.........))...(((((((.....(((....))).......))))))).]((((.(((..(((((((..(((...((..((((((..((....))...))))))..))...))))))))..)))))(((((.........)))))........((..........(.(((.......))).)..)..)....))))...))..)))))).)..))).)))))))).))))))......).[..(((((.....>].)))))..(((((((..(((.((......((((.((((((..(((((.(((((((((.((.(((.((((..(((.(......[..(((((..(((.......((((..........))))....)))...........].)))))).)))..)))).))).))...(((..(((((.....))))).)))....)))))))))..)))))..(((......[)))((((((..........]))))))(.((...(((((((.(.(((((.........)))))...).((.[.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....))..))).)))))))[...(((((((....(((..(((((((.....(....)....)))))))((((((...((((...(((((((((((.}}.))))))..)))))...)))).))))))..(((....((((.....}.......))))....))).)))...]....)))))))(.(......)....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))...)))) Mycoplasma pneumoniae 70S ribosome in untreated cells; 23S ribosomal RNA 7p6z 4 105 3.5 RF00001 URS000000E851_272634 36171285 0003735 0005840 272634 uuuggugcccaugucgcuguggaaacaccugguuccauuucgaacccagcaguuaagcacaguggagccgaauguagcugcagugagaauaggaaagcaccaagc <<<<<<<<.....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<..<....<<<..>>>.....>.>>...>>>>>>>>. .(((((((.....((((((((.....((((((...(.....)...))))..))....)))))).))..(.......(......).......)....))))))).. Mycoplasma pneumoniae 70S ribosome in untreated cells; 5S ribosomal RNA 7p6z 5 1493 3.5 RF00177,RF01959,RF01960 URS00019B76CF_272634 36171285 0003735 0005840 272634 ucugagaguuugauccuggcucaggauuaacgcuggcggcaugccuaauacaugcaagucgaucgaaaguaguaauacuuuagaggcgaacgggugaguaacacguauccaaucuaccuuauaaugggggauaacuaguugaaagacuagcuaauaccgcauaagaacuuugguucgaaucaaaguugaaaggaccugcaaggguucguuauuugaugagggugcgccauaucagcuaguuggugggguaacggccuaccaaggcaaugacguguagcuaugcugagaaguagaauagccacaaugggacugagacacggcccauacuccuacgggaggcagcaguagggaauuuuucacaaugagcgaaagcuugauggagcaaugccgcgugaacgaugaaggucuuuaagauuguaaaguucuuuuauuugggaagaaugacuuuagcagguaauggcuagaguuugacuguaccauuuugaauaagugacgacuaacuaugugccagcagucgcgguaauacauaggucgcaagcguuauccggauuuauugggcguaaagcaagcgcaggcggauugaaaagucugguguuaaaggcagcugcuuaacaguuguaugcauuggaaacuauuaaucuagagugugguagggaguuuuggaauuucauguggagcggugaaaugcguagauauaugaaggaacaccaguggcgaaggcgaaaacuuaggccauuacugacgcuuaggcuugaaaguguggggagcaaauaggauuagauacccuaguaguccacaccguaaacgauagauacuagcugucggggcgauccccucgguagugaaguuaacacauuaaguaucucgccuggguaguacauucgcaagaaugaaacucaaacggaauugacggggacccgcacaagugguggagcauguugcuuaauucgacgguacacgaaaaaccuuaccuagacuugacauccuuggcaaaguuauggaaacauaaugccgagugacagguggugcaugguugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuuaucguuaguuacauugucuagcgagacugcuaaugcaaauuggaggaaggaagggaugacgucaaaucaucaugccccuuaugucuagggcugcaaacgugcuacaauggccaauacaaacagucgccagcuuguaaaagugagcaaaucuguaaaguuggucucaguucggauugagggcugcaauucguccucaugaagucggaaucacuaguaaucgcgaaucagcuaugucgcggugaauacguucucgggucuuguacacaccgcccgucaaacuaugaaagcugguaauauuuaaaaacguguugcuaaccauuaggaagcgcaugucaaggauagcaccggugauuggaguuaagucguaacaagguaccccuacgagaacguggggguggauca .....<<<<..[.(((..>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<<<<<....>>>>>>.>>>>>......<<........<<<<<<<..<<...<..<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<<<<<<<<..>>>>>>>>>>....<<<<<<....>>>>>>.>>>>..>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<.......<<<.....>>>......>>>>...<...<<<.......<.<<<<<<<........>>>>>>>..>.......>>>....>.....<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<..<<<<<<<<<<.....<<<<<<<.....>>>>>>>..>>>>>>>>..>>.>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<<..<<<......>>>.....>>>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<......>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<.....<<<<<....>>>>>...>>>....))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<....<<<<<<....>>>>>>.>>>>>.>>.<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<.........>>>>>>>.....<<<<<....>>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>....>>>>>>>......<..<.<<<<<<<........>>>>>>>>...>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<..<<<<<....<<<<<.<<<<..<<....>>.>>>>>>>>>...>>>>>..>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((....)))))).)))))......(((.......((.((((..((...(..((((((.((.....(((((......)))))......)).).....(((((((..(())..)))))))....((((((....)))))))))))..)..)))))).)).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(.(((....)))..))))).)).))))))..((((........((.....)).......))))....(..(((...(.....((.((((........)))).)).....)....)))...)......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.((((((..((((((((((.....(((.(((.....))).)))..))))))))..)).))))))..((((.((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))))..)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((.((......)).)))))))...((..]])).....)))))))))).(((.......(((....))).....)))....]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((.....((.((....)).))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((.(((.........))).)))..(..(.(((....))).).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(.((((......(((..(((.((((....))))).))....))).....)))).)......(....(((((((........)))))))....)..)..))))).....(.(((((..........))))).)......))...)))))))))).))..(.(..((.(.((((.(((..((((((..(((((....((((((.(((..((....)).)))))))))...)))))..))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Mycoplasma pneumoniae 70S ribosome in untreated cells; 16S ribosomal RNA 7p6z 7 76 3.5 RF00005 URS000054164D_272634 36171285 0030533 0006412 272634 ggucuuguagcucagucgguagagcaacggucugaagaaccgugugucggcaguucgauucugcccgagaccacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (.(((.(..((((........)))).(((((.......))))).....(((((.......)))))).))).).... Mycoplasma pneumoniae 70S ribosome in untreated cells; tRNA-Phe 7p7q A 2901 2.4 RF02540,RF02541,RF00002 URS0002335906_1351 35387982,30404935 0003735 0005840 1351 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(.((((......((((((((((.....(((..(((((((((((((......((((((.[[..[[[)))...].((((((...(((]]..]].)))......))))))...)))....(((....)))(((((((......))))))).((..(((((.........)))))..)).))....(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((((((())))))))....{.((((((((.....(((.((.(((((((((.(((...(((.(......).)))[[(...).(((.....]])))...)))...))))))))))))))..))))..)))))....((((((((..[......))))))))....}.(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((..((((..[...))))..)))).<.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))......)))))))))))))..((.(...(((.((.....((((((((((.((((...((((((......))))))...)<)))...(((.(((((.......A))))))))..).))))))))).(.(((....[)))...).])).)))......).))..((((((....(((((....)))))((((((((....((((((((((.....(((...((((((((...((.((((.....))))..))...))))))))..)).).....)))).))))).).)))))).))..(((((((.((......)).)))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((...(..(((.........)))..).......(...((......)).).)))))...)))))))))).))...........]]].)...))))))))))...)))))))((((((((....))))))))....))))))(.(((((((.((......(((((.((....))])))))...)).)))))))..).....))))))(......((....((((((.......))))))((((....(((...((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((((((((......((...((((....((((..(((..(((((.((((((....{{....))))))((..(((((..((((.(((((((((.....))))))))).....))))..)))))...))...((.........))....)))))...)))...))))(..).....))))..))..))))))))))))))).))).....((......))..))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.[..).....)))))(((((......)))))(...).......(((((((((.>.((.........))...(((((((.....(((....))).......))))))).]((((.(((..(((((((..(((...((...(((((..((....))...)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).[..(((((.....>].)))))..((((((((.(((.((......((((.((((((..(((((.(((((((((.(((.(((((((.((((.(.........(((((..(((.......(((((((....)))))))....)))............)))))).)))).))))))).)))....((.((((((.....)))))))).....)))))))))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..a.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((.....))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...))))).). E. faecalis 70S ribosome bound by PoxtA-EQ2, high-resolution combined volume; 23S rRNA 7p7q B 114 2.4 RF00001 URS0000240630_1351 35387982,30404935 0003735 0005840 1351 gugguggcgauagcgagaaggauacaccuguucccaugccgaacacagaaguuaagcuucuuagcgccgauuguagugaaggguuucccuuugugagaguaggacgucgccacg <<<<<<<<....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>..>>>>>>>>. ((((((((....((((((((.....((((((...(.....)...))))..))....)))))).)).((.......((((((((...)))))))).......))..)))))))). E. faecalis 70S ribosome bound by PoxtA-EQ2, high-resolution combined volume; 5S rRNA 7p7q D 76 2.4 RF00005 URS00023119F2_1351 35387982,30404935 0030533 0006412 1351 gcgggguggagcagucagguagcucgucgggcucauaacccgaaggucguagguucaaauccugcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... E. faecalis 70S ribosome bound by PoxtA-EQ2, high-resolution combined volume; fMet-tRNA 7p7q a 1521 2.4 RF00177,RF01959,RF01960 URS00023358DE_1351 35387982,30404935 0003735 0005840 1351 gagaguuugauccuggcucaggacgaacgcuggcggcgugccuaauacaugcaagucgaacgcuucuuaagaggaguggcggacgggugaguaacacguggguaaccuacccaucagagggggauaacacuuggaaacaggugcuaauaccgcauaacaguuuaugccgcauggcauaagagugaaaggcgcuggugucgcugauggauggacccgcggugcauuagcuaguuggugagguaacggcucaccaaggccacgaugcauagccgaccugagagggugaucggccacacugggacugagacacggcccagacuccuacgggaggcagcaguagggaaucuucggcaauggacgaaagucugaccgagcaacgccgcgugagugaagaagguuuucggaucguaaaacucuguuguuagagaagaacaaggacguuaguaacugaacguccccugacgguaucuaaccagaaagccacggcuaacuacgugccagcagccgcgguaauacguagguggcaagcguuguccggauuuauugggcguaaagcgagcgcaggcgguuucuuaagucugaugugaaagcccccggcucaaccggggagggucauuggaaacugggagacuugagugcagaagaggagaguggaauuccauguguagcggugaaaugcguagauauauggaggaacaccaguggcgaaggcggcucucuggucuguaacugacgcugaggcucgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugagugcuaaguguuggaggguuuccgcccuucagugcugcagcaaacgcauuaagcacuccgccuggggaguacgaccgcaagguugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggucuugacauccuuugaccacucuagagauagagcuuucccuucggggacaaagugacagguggugcaugguugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuuauuguuaguugccaucauuuaguugggcacucuagcgagacugccggugacaaaccggaggaagguggggaugacgucaaaucaucaugccccuuaugaccugggcuacacacgugcuacaaugggaaguacaacgagucgcuagaccgcgaggucaugcaaaucucuuaaagcuucucucaguucggauugcaggcugcaacucgccugcaugaagccggaaucgcuaguaaucgcggaucagcacgccgcggugaauacguucccgggccuuguacacaccgcccgucacaccacgagaguuuguaacacccgaagucggugagguaaccuuuuuggagccagccgccuaaggugggauagaugauuggggugaagucguaacaagguagccguaucggnnggugcggcuggaucaccuccu ..<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<....>>>>.>>>>>......<<........<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<<....>>>>>>......>>.>.......<<<<<<<<<..>>>>>>>>>.......<<<<<..>>>>>.>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<<.........<<<<<<<........>>>>>>>..........>>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<.......<<<<<<.....>>>>>>.....>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<<..<<<......>>>.....>>>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<<....>>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<.......<<<<<....>>>>>...<<<<<..>>>>>...>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<......>>>>>...>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<..<<<<...<<.<<<<..<<<..<<.....>>.>>>.>>>>.>>..>>>>..>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ ..((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..(..((((....))))..))))......(((.......(((((((..((...(((((((.(.((.....((((((....))))))......)).)........(((((((....)))))))........(((((()))))).)))))))..))))))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....((((((...(.....(((((((........))))))).....)....))))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))...).)))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((((((....)))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((...(....(((((....)))))...(((((..))))))...).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..((......)))))...)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((..((((....(.((((..(((..((.....)).))).)))).)...))))..))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... E. faecalis 70S ribosome bound by PoxtA-EQ2, high-resolution combined volume; 16S rRNA 7p7q b 13 2.4 35387982,30404935 1351 ggagguaugacaa ............. ............. E. faecalis 70S ribosome bound by PoxtA-EQ2, high-resolution combined volume; mRNA 7p7r A 2901 2.9 RF02540,RF02541,RF00002 URS0002311A01_226185 35387982,30404935 0003735 0005840 226185 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<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<..<<<<<.........>>>>>..>>.>>....<<<<<......<<....>>.......>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..(((....<<<<<<<..>>>>>>>......<<<<<<<<.....<<<.<<.<<<<<<<<<.<<<...<<<.<......>.>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>..>>>>..>>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<....>>>>..................>>>>>>>>>>>.......<<<<..<<<<......>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>......>>>>>>>>>>>>>..<<.<..<<<<.<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>.>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<.<...<<<<<<<<<.....<<<...<<<<<<<<...<<<<<<<.....>>>>>.>>...>>>>>>>>..>>.>.....>>>>.>>>>>..>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<..<...<<<<.......>>>>...>..........<<......>>...>>>>>....>>>>>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<....>>>>>>>>....>>>>>>..<<<<<<<.<<......<<<<<.<<....>>.>>>>>...>>.>>>>>>>........>>>>>><......<<....<<<<<<.......>>>>>><<<<....<<<<<.<<<..<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<......<<...<<<<....<<<<..<<...<<<<<.<<<<<<...(((....>>>>>><<..<<<<<..<<<<.<<<<<<<<<.....>>>>>>>>>.....>>>>..>>>>>...>>...<<.........>>....>>>>>....>>...>>>>.........>>>>..>>..>>>>>>>>>>>>>>>.>>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<....>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<..<<....>>...>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<<.<<<.<<<<<<<.<<<<...........<<<<<..<<<.......<<<<<<<....>>>>>>>....>>>............>>>>>..>>>>.>>>>>>>.>>>....<<.<<<<<<.....>>>>>>>>.....>>>>>>>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.)))>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>...>>>>....>>>>>>. (.((((......((((((((((.....(((..(((((((((((((......((((((.[[..[[[)))...].((((((...(((]]..]].)))......))))))...)))....(((....)))(((((((......))))))).((..(((((.........)))))..)).))....(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((((((())))))))....{.((((((((.....(((.((.(((((((((.(((...(((.(......).)))[[(...).(((.....]])))...)))...))))))))))))))..))))..)))))....((((((((..[......))))))))....}.(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((..((((..[...))))..)))).<.(.(........).).((((((..(.(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))......)))))))))))))..((.(...(((.((.....((((((((((.((((...((((((......))))))...)<)))...(((.(((((.......A))))))))..).))))))))).(.(((....[)))...).])).)))......).))).((((((....(((((....)))))((((((((....((((((((((.....(((...((((((((...((.((((.....))))..))...))))))))..)).).....)))).))))).).)))))).))..(((((((.((......)).)))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((...(..(((.........)))..).......(...((......)).).)))))...)))))))))).))...........]]].)...))))))))))...)))))))((((((((....))))))))....))))))(.(((((((.((......(((((.((....))])))))...)).)))))))..).....))))))(......((....((((((.......))))))((((....(((...((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((((((((......((...((((....((((..(((..(((((.((((((....{{....))))))((..(((((..((((.(((((((((.....))))))))).....))))..)))))...))...((.........))....)))))...)))...))))(..).....))))..))..))))))))))))))).))).....((......))..))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.[..).....)))))(((((......)))))(...).......(((((((((.>.((.........))...(((((((.....(((....))).......))))))).]((((.(((..(((((((..(((...((...(((((..((....))...)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).[..(((((.....>].)))))..((((((((.(((.((......((((.((((((..(((((.(((((((((.(((.(((((((.((((.(.........(((((..(((.......(((((((....)))))))....)))............)))))).)))).))))))).)))....((.((((((.....)))))))).....)))))))))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..a.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((.....))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...))))).). PoxtA-EQ2 antibiotic resistance ABCF bound to E. faecalis 70S ribosome, state I; 23S rRNA 7p7r B 114 2.9 RF00001 URS00023358F1_226185 35387982,30404935 0003735 0005840 226185 gugguggcgauagcgagaaggauacaccuguucccaugccgaacacagaaguuaagcuucuuagcgccgauuguagugaaggguuucccuuugugagaguaggacgucgccacg <<<<<<<<....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>..>>>>>>>>. ((((((((....((((((((.....((((((...(.....)...))))..))....)))))).)).((.......((((((((...)))))))).......))..)))))))). PoxtA-EQ2 antibiotic resistance ABCF bound to E. faecalis 70S ribosome, state I; 5S rRNA 7p7r D 76 2.9 RF00005 URS00023119F2_226185 35387982,30404935 0030533 0006412 226185 gcgggguggagcagucagguagcucgucgggcucauaacccgaaggucguagguucaaauccugcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... PoxtA-EQ2 antibiotic resistance ABCF bound to E. faecalis 70S ribosome, state I; tRNA-fMet 7p7r a 1521 2.9 RF00177,RF01959,RF01960 URS00023358DE_226185 35387982,30404935 0003735 0005840 226185 gagaguuugauccuggcucaggacgaacgcuggcggcgugccuaauacaugcaagucgaacgcuucuuaagaggaguggcggacgggugaguaacacguggguaaccuacccaucagagggggauaacacuuggaaacaggugcuaauaccgcauaacaguuuaugccgcauggcauaagagugaaaggcgcuggugucgcugauggauggacccgcggugcauuagcuaguuggugagguaacggcucaccaaggccacgaugcauagccgaccugagagggugaucggccacacugggacugagacacggcccagacuccuacgggaggcagcaguagggaaucuucggcaauggacgaaagucugaccgagcaacgccgcgugagugaagaagguuuucggaucguaaaacucuguuguuagagaagaacaaggacguuaguaacugaacguccccugacgguaucuaaccagaaagccacggcuaacuacgugccagcagccgcgguaauacguagguggcaagcguuguccggauuuauugggcguaaagcgagcgcaggcgguuucuuaagucugaugugaaagcccccggcucaaccggggagggucauuggaaacugggagacuugagugcagaagaggagaguggaauuccauguguagcggugaaaugcguagauauauggaggaacaccaguggcgaaggcggcucucuggucuguaacugacgcugaggcucgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugagugcuaaguguuggaggguuuccgcccuucagugcugcagcaaacgcauuaagcacuccgccuggggaguacgaccgcaagguugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggucuugacauccuuugaccacucuagagauagagcuuucccuucggggacaaagugacagguggugcaugguugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuuauuguuaguugccaucauuuaguugggcacucuagcgagacugccggugacaaaccggaggaagguggggaugacgucaaaucaucaugccccuuaugaccugggcuacacacgugcuacaaugggaaguacaacgagucgcuagaccgcgaggucaugcaaaucucuuaaagcuucucucaguucggauugcaggcugcaacucgccugcaugaagccggaaucgcuaguaaucgcggaucagcacgccgcggugaauacguucccgggccuuguacacaccgcccgucacaccacgagaguuuguaacacccgaagucggugagguaaccuuuuuggagccagccgccuaaggugggauagaugauuggggugaagucguaacaagguagccguaucggaaggugcggcuggaucaccuccu ..<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<....>>>>.>>>>>......<<........<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<<....>>>>>>......>>.>.......<<<<<<<<....>>>>>>>>.......<<<<<..>>>>>.>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<<<<<<<.........<<<<<<<........>>>>>>>..........>>>>>>...>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<.......<<<<<<.....>>>>>>.....>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<<..<<<......>>>.....>>>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<<....>>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<.......<<<<<....>>>>>...<<<<<..>>>>>...>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<......>>>>>...>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<..<<<<...<<.<<<<..<<<..<<.....>>.>>>.>>>>.>>..>>>>..>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ ..((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..(..((((....))))..))))......(((.......(((((((..((...(((((((.(.((.....((((((....))))))......)).)........(((((((....)))))))........(((((()))))).)))))))..))))))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..(.((((((...(.....(((((((........))))))).....)....))))))....).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))...).)))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((((((....)))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((...(....(((((....)))))...(((((..))))))...).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..((......)))))...)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((..((((....(.((((..(((..((.....)).))).)))).)...))))..))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... PoxtA-EQ2 antibiotic resistance ABCF bound to E. faecalis 70S ribosome, state I; 16S rRNA 7p7r b 13 2.9 35387982,30404935 226185 ggagguaugacaa ............. ............. PoxtA-EQ2 antibiotic resistance ABCF bound to E. faecalis 70S ribosome, state I; mRNA 7p7s A 2901 3.0 RF02540,RF02541,RF00002 URS0002311A01_1351 35387982,30404935 0003735 0005840 1351 uuaagugaauaagggcgcacgguggaugccuuggcacuaggagccgaugaaggacgggacuaacaccgauaugcuuuggggagcuguaaguaagcuaugauccagagauuuccgaaugggggaacccaauaucuuuuauaggauauuacuuuucagugaauacauagcugauuagagguagacgcagagaacugaaacaucuuaguaccugcaggaagagaaagaaaauucgauucccugaguagcggcgagcgaaacgggaagagcccaaaccaacaagcuuguugggguuguaggacuccgauaugguagucuguuaguauaguugaaggauuuggaaaauuccgcuaaagagggugaaagccccguagacgaaaugcugacaacaccuaggaggauccugaguacggcggaacacgagaaauuccgucggaauccgcggggaccaucccgcaaggcuaaauacucccuagugaccgauagugaaccaguaccgugagggaaaggugaaaagcaccccggaaggggagugaaauagauccugaaaccgugugccuacaacaagucaaagcucguuaaugagugauggcgugccuuuuguagaaugaaccggcgaguuacgauugcaugcgagguuaagucgaagagacggagccgcagcgaaagcgagucugaauagggcgaaugaguauguagucguagacccgaaaccaugugaucuacccauguccagguugaaggugcgguaaaacgcacuggaggaccgaacccacguacguugaaaagugcggggaugagguguggguagcggagaaauuccaaacgaacuuggagauagcugguucucuccgaaauagcuuuagggcuagccucggaauugagaaugauggagguagagcacuguuuggacuaggggcccaucucggguuaccgaauucagauaaacuccgaaugccauucauuuauauccgggagucagacugcgagugauaagauccguagucgaaagggaaacagcccagaccaccagcuaaggucccaaaauauauguuaaguggaaaaggaugugggguugcacagacaacuaggauguuggcuuagaagcagccaccauuuaaagagugcguaauagcucacuagucgagugacccugcgccgaaaauguaccggggcuaaacauauuaccgaagcuguggacuacaccauuagguguagugguaggagagcguucuaagggcguugaaggucgaucgugaggacggcuggagcgcuuagaagugagaaugccgguaugaguagcgaaagacaggugagaauccuguccaccguaugacuaagguuuccuggggaaggcucguccgcccaggguuagucgggaccuaagccgaggccgauaggcguaggcgauggacaacagguugauauuccuguaccaguuguuuuuguuugagcaauggagggacgcaguaggcuaaggaaugcaugcgauuggaagugcauguccaagcaaugagucuugaguagaguuaaaugcuuuacucuuuaaggacaaguugugacggggagcgaaauaguagcgaaguuccugacgucacacugccaagaaaagcuucuagugagaaaacaacugcccguaccguaaaccgacacagguagucgaggagaguauccuaaggugagcgagcgaacucucguuaaggaacucggcaaaaugaccccguaacuucgggagaaggggugcugacuucggucagccgcagugaauaggcccaagcgacuguuuaucaaaaacacaggucucugcaaaaucguaagaugaaguauaggggcugacgccugcccggugcuggaagguuaagaggauggguuagcuucggcgaagcucagaauugaagccccaguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgacccgcacgaaaggcguaacgauuugggcacugucucaacgagagacucggugaaauuuuaguaccugugaagaugcagguuacccgcgacaggacggaaagaccccauggagcuuuacuguaguuugauauugaguguuuguaccacauguacaggauagguaggagccgaugagaccggaacgcuaguuucggaggaggcgcuggugggauacuacccuuguguuaugaacccucuaacccgcaccacuaaucguggugggagacagugucagaugggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguucccucagaaugguuggaaaucauucgaagaguguaaaggcagaagggagcuugacugcgagaccuacaagucgagcagggacgaaagucgggcuuagugauccggugguuccgcauggaagggccaucgcucaacggauaaaagcuacccuggggauaacaggcuuaucucccccaagaguccacaucgacggggagguuuggcaccucgaugucggcucgucgcauccuggggcuguagucggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucccuauccgucgcgggcguuggaaauuugagaggagcuguccuuaguacgagaggaccgggauggacuuaccgcugguguaccaguuguucugccaagggcauugcuggguagcuauguagggaagggauaaacgcugaaagcaucuaagugugaagcccaccucaagaugagauuucccauuucuuuaagaaaguaagaccccugagagaugaucagguagauagguuggaaguggaaggcuagugauaguuggagcggaccaauacuaaucggucgaggacuuaac <<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<..<<<<<.........>>>>>..>>.>>....<<<<<......<<....>>.......>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..(((....<<<<<<<..>>>>>>>......<<<<<<<<.....<<<.<<.<<<<<<<<<.<<<...<<<.<......>.>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>..>>>>..>>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<....>>>>..................>>>>>>>>>>>.......<<<<..<<<<......>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>......>>>>>>>>>>>>>..<<.<...<<<.<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>.>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<.<...<<<<<<<<<.....<<<...<<.<<<<<...<<<<<<<.....>>>>>.>>...>>>>>.>>..>>.>.....>>>>.>>>>>..>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<......<<<.........>>>..............<<......>>...>>>>>....>>>>>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<....>>>>>>>>....>>>>>>..<<<<<<<.<<......<<<<<.<<....>>.>>>>>...>>.>>>>>>>........>>>>>><......<<....<<<<<<.......>>>>>><<<<....<<<<<.<<<..<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<......<<...<<<<....<<<<..<<...<<<<<.<<<<<<...(((....>>>>>><<..<<<<<..<<<<.<<<<<<<<<.....>>>>>>>>>.....>>>>..>>>>>...>>...<<.........>>....>>>>>....>>...>>>>.........>>>>..>>..>>>>>>>>>>>>>>>.>>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<....>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<..<<....>>...>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<<.<<<.<<<<<<<.<<<<...........<<<<<..<<<.......<<<<<<<....>>>>>>>....>>>............>>>>>..>>>>.>>>>>>>.>>>....<<.<<<<<<.....>>>>>>>>.....>>>>>>>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.)))>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>...>>>>....>>>>>>. (.((((......((((((((((.....(((..(((((((((((((......((((((.[[..[[[)))...].((((((...(((]]..]].)))......))))))...)))....(((....)))(((((((......))))))).((..(((((.........)))))..)).))....(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((((((())))))))....{.((((((((.....(((.((.(((((((((.(((...(((.(......).)))[[(...).(((.....]])))...)))...))))))))))))))..))))..)))))....((((((((..[......))))))))....}.(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((..((((..[...))))..)))).<.(.(........).).((((((..(.(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))......)))))))))))))..((.(...(((.((.....((((((((((.((((...((((((......))))))...)<)))...(((.(((((.......A))))))))..).))))))))).(.(((....[)))...).])).)))......).))).((((((....(((((....)))))((((((((....((((((((((.....(((...((((((((...((.((((.....))))..))...))))))))..)).).....)))).))))).).)))))).))..(((((((.((......)).)))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((...(..(((.........)))..).......(...((......)).).)))))...)))))))))).))...........]]].)...))))))))))...)))))))((((((((....))))))))....))))))(.(((((((.((......(((((.((....))])))))...)).)))))))..).....))))))(......((....((((((.......))))))((((....(((...((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((((((((......((...((((....((((..(((..(((((.((((((....{{....))))))((..(((((..((((.(((((((((.....))))))))).....))))..)))))...))...((.........))....)))))...)))...))))(..).....))))..))..))))))))))))))).))).....((......))..))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.[..).....)))))(((((......)))))(...).......(((((((((.>.((.........))...(((((((.....(((....))).......))))))).]((((.(((..(((((((..(((...((...(((((..((....))...)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).[..(((((.....>].)))))..((((((((.(((.((......((((.((((((..(((((.(((((((((.(((.(((((((.((((.(.........(((((..(((.......(((((((....)))))))....)))............)))))).)))).))))))).)))....((.((((((.....)))))))).....)))))))))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..a.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((.....))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...))))).). PoxtA-EQ2 antibiotic resistance ABCF bound to E. faecalis 70S ribosome, state II; 23S rRNA 7p7s B 114 3.0 RF00001 URS0000240630_1351 35387982,30404935 0003735 0005840 1351 gugguggcgauagcgagaaggauacaccuguucccaugccgaacacagaaguuaagcuucuuagcgccgauuguagugaaggguuucccuuugugagaguaggacgucgccacg <<<<<<<<....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>..>>>>>>>>. ((((((((....((((((((.....((((((...(.....)...))))..))....)))))).)).((.......((((((((...)))))))).......))..)))))))). PoxtA-EQ2 antibiotic resistance ABCF bound to E. faecalis 70S ribosome, state II; 5S rRNA 7p7s D 76 3.0 RF00005 URS00023358BB_1351 35387982,30404935 0030533 0006412 1351 gcgggguggagcagucagguagcucgucgggcucauaacccgaaggucguagguucaaauccugcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... PoxtA-EQ2 antibiotic resistance ABCF bound to E. faecalis 70S ribosome, state II; tRNA-fMet 7p7s a 1521 3.0 RF00177,RF01959,RF01960 URS00023358DE_1351 35387982,30404935 0003735 0005840 1351 gagaguuugauccuggcucaggacgaacgcuggcggcgugccuaauacaugcaagucgaacgcuucuuaagaggaguggcggacgggugaguaacacguggguaaccuacccaucagagggggauaacacuuggaaacaggugcuaauaccgcauaacaguuuaugccgcauggcauaagagugaaaggcgcuggugucgcugauggauggacccgcggugcauuagcuaguuggugagguaacggcucaccaaggccacgaugcauagccgaccugagagggugaucggccacacugggacugagacacggcccagacuccuacgggaggcagcaguagggaaucuucggcaauggacgaaagucugaccgagcaacgccgcgugagugaagaagguuuucggaucguaaaacucuguuguuagagaagaacaaggacguuaguaacugaacguccccugacgguaucuaaccagaaagccacggcuaacuacgugccagcagccgcgguaauacguagguggcaagcguuguccggauuuauugggcguaaagcgagcgcaggcgguuucuuaagucugaugugaaagcccccggcucaaccggggagggucauuggaaacugggagacuugagugcagaagaggagaguggaauuccauguguagcggugaaaugcguagauauauggaggaacaccaguggcgaaggcggcucucuggucuguaacugacgcugaggcucgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugagugcuaaguguuggaggguuuccgcccuucagugcugcagcaaacgcauuaagcacuccgccuggggaguacgaccgcaagguugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggucuugacauccuuugaccacucuagagauagagcuuucccuucggggacaaagugacagguggugcaugguugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuuauuguuaguugccaucauuuaguugggcacucuagcgagacugccggugacaaaccggaggaagguggggaugacgucaaaucaucaugccccuuaugaccugggcuacacacgugcuacaaugggaaguacaacgagucgcuagaccgcgaggucaugcaaaucucuuaaagcuucucucaguucggauugcaggcugcaacucgccugcaugaagccggaaucgcuaguaaucgcggaucagcacgccgcggugaauacguucccgggccuuguacacaccgcccgucacaccacgagaguuuguaacacccgaagucggugagguaaccuuuuuggagccagccgccuaaggugggauagaugauuggggugaagucguaacaagguagccguaucggaaggugcggcuggaucaccuccu ..<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<....>>>>.>>>>>......<<........<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<<....>>>>>>......>>.>.......<<<<<<<<....>>>>>>>>.......<<<<<..>>>>>.>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<<<<<<<.........<<<<<<<........>>>>>>>..........>>>>>>...>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<.......<<<<<<.....>>>>>>.....>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<<..<<<......>>>.....>>>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<<....>>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<.......<<<<<....>>>>>...<<<<....>>>>...>>.>>.<<<.<<<..<<<<<<.<.....<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<......>>>>>...>>>>>>>.....<<<<<.....>>>>>........>>>>.....>...>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<..<.<<<<<<<........>>>>>>>>...>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<..<<<<...<<.<<<<..<<<..<<.....>>.>>>.>>>>.>>..>>>>..>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ ..((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..(..((((....))))..))))......(((.......(((((((..((...(((((((.(.((.....((((((....))))))......)).)........(((((((....)))))))........(((((()))))).)))))))..))))))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....((((((...(.....(((((((........))))))).....)....))))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))...).)))))))..)))))))))..(((((((((...((((((((....(((((.(...((........))......).)))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((((((....)))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((...(....(((((....)))))...(((((..))))))...).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..((......)))))...)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((..((((....(.((((..(((..((.....)).))).)))).)...))))..))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... PoxtA-EQ2 antibiotic resistance ABCF bound to E. faecalis 70S ribosome, state II; 16S rRNA 7p7s b 13 3.0 35387982,30404935 1351 ggagguaugacaa ............. ............. PoxtA-EQ2 antibiotic resistance ABCF bound to E. faecalis 70S ribosome, state II; mRNA 7p7t A 2901 2.9 RF02540,RF02541,RF00002 URS0002311A01_1351 35387982,30404935 0003735 0005840 1351 uuaagugaauaagggcgcacgguggaugccuuggcacuaggagccgaugaaggacgggacuaacaccgauaugcuuuggggagcuguaaguaagcuaugauccagagauuuccgaaugggggaacccaauaucuuuuauaggauauuacuuuucagugaauacauagcugauuagagguagacgcagagaacugaaacaucuuaguaccugcaggaagagaaagaaaauucgauucccugaguagcggcgagcgaaacgggaagagcccaaaccaacaagcuuguugggguuguaggacuccgauaugguagucuguuaguauaguugaaggauuuggaaaauuccgcuaaagagggugaaagccccguagacgaaaugcugacaacaccuaggaggauccugaguacggcggaacacgagaaauuccgucggaauccgcggggaccaucccgcaaggcuaaauacucccuagugaccgauagugaaccaguaccgugagggaaaggugaaaagcaccccggaaggggagugaaauagauccugaaaccgugugccuacaacaagucaaagcucguuaaugagugauggcgugccuuuuguagaaugaaccggcgaguuacgauugcaugcgagguuaagucgaagagacggagccgcagcgaaagcgagucugaauagggcgaaugaguauguagucguagacccgaaaccaugugaucuacccauguccagguugaaggugcgguaaaacgcacuggaggaccgaacccacguacguugaaaagugcggggaugagguguggguagcggagaaauuccaaacgaacuuggagauagcugguucucuccgaaauagcuuuagggcuagccucggaauugagaaugauggagguagagcacuguuuggacuaggggcccaucucggguuaccgaauucagauaaacuccgaaugccauucauuuauauccgggagucagacugcgagugauaagauccguagucgaaagggaaacagcccagaccaccagcuaaggucccaaaauauauguuaaguggaaaaggaugugggguugcacagacaacuaggauguuggcuuagaagcagccaccauuuaaagagugcguaauagcucacuagucgagugacccugcgccgaaaauguaccggggcuaaacauauuaccgaagcuguggacuacaccauuagguguagugguaggagagcguucuaagggcguugaaggucgaucgugaggacggcuggagcgcuuagaagugagaaugccgguaugaguagcgaaagacaggugagaauccuguccaccguaugacuaagguuuccuggggaaggcucguccgcccaggguuagucgggaccuaagccgaggccgauaggcguaggcgauggacaacagguugauauuccuguaccaguuguuuuuguuugagcaauggagggacgcaguaggcuaaggaaugcaugcgauuggaagugcauguccaagcaaugagucuugaguagaguuaaaugcuuuacucuuuaaggacaaguugugacggggagcgaaauaguagcgaaguuccugacgucacacugccaagaaaagcuucuagugagaaaacaacugcccguaccguaaaccgacacagguagucgaggagaguauccuaaggugagcgagcgaacucucguuaaggaacucggcaaaaugaccccguaacuucgggagaaggggugcugacuucggucagccgcagugaauaggcccaagcgacuguuuaucaaaaacacaggucucugcaaaaucguaagaugaaguauaggggcugacgccugcccggugcuggaagguuaagaggauggguuagcuucggcgaagcucagaauugaagccccaguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgacccgcacgaaaggcguaacgauuugggcacugucucaacgagagacucggugaaauuuuaguaccugugaagaugcagguuacccgcgacaggacggaaagaccccauggagcuuuacuguaguuugauauugaguguuuguaccacauguacaggauagguaggagccgaugagaccggaacgcuaguuucggaggaggcgcuggugggauacuacccuuguguuaugaacccucuaacccgcaccacuaaucguggugggagacagugucagaugggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguucccucagaaugguuggaaaucauucgaagaguguaaaggcagaagggagcuugacugcgagaccuacaagucgagcagggacgaaagucgggcuuagugauccggugguuccgcauggaagggccaucgcucaacggauaaaagcuacccuggggauaacaggcuuaucucccccaagaguccacaucgacggggagguuuggcaccucgaugucggcucgucgcauccuggggcuguagucggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucccuauccgucgcgggcguuggaaauuugagaggagcuguccuuaguacgagaggaccgggauggacuuaccgcugguguaccaguuguucugccaagggcauugcuggguagcuauguagggaagggauaaacgcugaaagcaucuaagugugaagcccaccucaagaugagauuucccauuucuuuaagaaaguaagaccccugagagaugaucagguagauagguuggaaguggaaggcuagugauaguuggagcggaccaauacuaaucggucgaggacuuaac <<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<..<<<<<.........>>>>>..>>.>>....<<<<<......<<....>>.......>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..(((....<<<<<<<..>>>>>>>......<<<<<<<<.....<<<.<<.<<<<<<<<<.<<<...<<<.<......>.>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>..>>>>..>>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<....>>>>..................>>>>>>>>>>>..<....<<<<..<<<<......>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>......>>>>>>>>>>>>>..<<.<..<<<<.<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>.>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<.<...<<<<<<<<<.....<<<...<<.<<<<<...<<<<<<<.....>>>>>.>>...>>>>>.>>..>>.>.....>>>>.>>>>>..>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<..<...<<<<.......>>>>...>..........<<......>>...>>>>>....>>>>>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<....>>>>>>>>....>>>>>>..<<<<<<<.<<......<<<<<.<<....>>.>>>>>...>>.>>>>>>>........>>>>>><......<<....<<<<<<.......>>>>>><<<<....<<<<<.<<<..<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<......<<...<<<<....<<<<..<<...<<<<<.<<<<<<...(((....>>>>>><<..<<<<<..<<<<.<<<<<<<<<.....>>>>>>>>>.....>>>>..>>>>>...>>...<<.........>>....>>>>>....>>...>>>>.........>>>>..>>..>>>>>>>>>>>>>>>.>>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<....>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<..<<....>>...>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>>.<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<<.<<<.<<<<<<<.<<<<...........<<<<<..<<<.......<<<<<<<....>>>>>>>....>>>............>>>>>..>>>>.>>>>>>>.>>>....<<.<<<<<<.....>>>>>>>>.....>>>>>>>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.)))>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>...>>>>....>>>>>>. (.((((......((((((((((.....(((..(((((((((((((......((((((.[[..[[[)))...].((((((...(((]]..]].)))......))))))...)))....(((....)))(((((((......))))))).((..(((((.........)))))..)).))....(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((((((())))))))....{.((((((((.....(((.((.(((((((((.(((...(((.(......).)))[[(...).(((.....]])))...)))...))))))))))))))..))))..)))))....((((((((..[......))))))))....}.(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((..((((..[...))))..)))).<.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))......)))))))))))))..((.(...(((.((.....((((((((((.((((...((((((......))))))...)<)))...(((.(((((.......A))))))))..).))))))))).(.(((....[)))...).])).)))......).))..((((((....(((((....)))))((((((((....((((((((((.....(((...((((((((...((.((((.....))))..))...))))))))..)).).....)))).))))).).)))))).))..(((((((.((......)).)))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((...(..(((.........)))..).......(...((......)).).)))))...)))))))))).))...........]]].)...))))))))))...)))))))((((((((....))))))))....))))))(.(((((((.((......(((((.((....))])))))...)).)))))))..).....))))))(......((....((((((.......))))))((((....(((...((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((((((((......((...((((....((((..(((..(((((.((((((....{{....))))))((..(((((..((((.(((((((((.....))))))))).....))))..)))))...))...((.........))....)))))...)))...))))(..).....))))..))..))))))))))))))).))).....((......))..))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.[..).....)))))(((((......)))))(...).......(((((((((.>.((.........))...(((((((.....(((....))).......))))))).]((((.(((..(((((((..(((...((...(((((..((....))...)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).[..(((((.....>].)))))..((((((((.(((.((......((((.((((((..(((((.(((((((((.(((.(((((((.((((.(.........(((((..(((.......(((((((....)))))))....)))............)))))).)))).))))))).)))....((.((((((.....)))))))).....)))))))))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..a.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((.....))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...))))).). PoxtA-EQ2 antibiotic resistance ABCF bound to E. faecalis 70S ribosome, state III; 23S rRNA 7p7t B 114 2.9 RF00001 URS0000240630_1351 35387982,30404935 0003735 0005840 1351 gugguggcgauagcgagaaggauacaccuguucccaugccgaacacagaaguuaagcuucuuagcgccgauuguagugaaggguuucccuuugugagaguaggacgucgccacg <<<<<<<<....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>..>>>>>>>>. ((((((((....((((((((.....((((((...(.....)...))))..))....)))))).)).((.......((((((((...)))))))).......))..)))))))). PoxtA-EQ2 antibiotic resistance ABCF bound to E. faecalis 70S ribosome, state III; 5S rRNA 7p7t C 72 2.9 RF00005 URS00023358DD_562 35387982,30404935 0030533 0006412 562 gagccguuagcucaguggagcaucugacunuunaucagagggucacaggnucgagcccuguacggcucacca <<<<<<<..<<<<....>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[)))).((((.........)))).....(((((..]....)))))))))))).... PoxtA-EQ2 antibiotic resistance ABCF bound to E. faecalis 70S ribosome, state III; A-site tRNA 7p7t D 76 2.9 RF00005 URS00023119F2_1351 35387982,30404935 0030533 0006412 1351 gcgggguggagcagucagguagcucgucgggcucauaacccgaaggucguagguucaaauccugcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... PoxtA-EQ2 antibiotic resistance ABCF bound to E. faecalis 70S ribosome, state III; tRNA-fMet 7p7t a 1521 2.9 RF00177,RF01959,RF01960 URS00023358DE_1351 35387982,30404935 0003735 0005840 1351 gagaguuugauccuggcucaggacgaacgcuggcggcgugccuaauacaugcaagucgaacgcuucuuaagaggaguggcggacgggugaguaacacguggguaaccuacccaucagagggggauaacacuuggaaacaggugcuaauaccgcauaacaguuuaugccgcauggcauaagagugaaaggcgcuggugucgcugauggauggacccgcggugcauuagcuaguuggugagguaacggcucaccaaggccacgaugcauagccgaccugagagggugaucggccacacugggacugagacacggcccagacuccuacgggaggcagcaguagggaaucuucggcaauggacgaaagucugaccgagcaacgccgcgugagugaagaagguuuucggaucguaaaacucuguuguuagagaagaacaaggacguuaguaacugaacguccccugacgguaucuaaccagaaagccacggcuaacuacgugccagcagccgcgguaauacguagguggcaagcguuguccggauuuauugggcguaaagcgagcgcaggcgguuucuuaagucugaugugaaagcccccggcucaaccggggagggucauuggaaacugggagacuugagugcagaagaggagaguggaauuccauguguagcggugaaaugcguagauauauggaggaacaccaguggcgaaggcggcucucuggucuguaacugacgcugaggcucgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugagugcuaaguguuggaggguuuccgcccuucagugcugcagcaaacgcauuaagcacuccgccuggggaguacgaccgcaagguugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggucuugacauccuuugaccacucuagagauagagcuuucccuucggggacaaagugacagguggugcaugguugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuuauuguuaguugccaucauuuaguugggcacucuagcgagacugccggugacaaaccggaggaagguggggaugacgucaaaucaucaugccccuuaugaccugggcuacacacgugcuacaaugggaaguacaacgagucgcuagaccgcgaggucaugcaaaucucuuaaagcuucucucaguucggauugcaggcugcaacucgccugcaugaagccggaaucgcuaguaaucgcggaucagcacgccgcggugaauacguucccgggccuuguacacaccgcccgucacaccacgagaguuuguaacacccgaagucggugagguaaccuuuuuggagccagccgccuaaggugggauagaugauuggggugaagucguaacaagguagccguaucggaaggugcggcuggaucaccuccu ..<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<<<....>>>>.>>>>>......<<........<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<<....>>>>>>......>>.>.......<<<<<<<<....>>>>>>>>.......<<<<<..>>>>>.>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<<<<<<<.........<<<<<<<........>>>>>>>..........>>>>>>...>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<.......<<<<<<.....>>>>>>.....>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<<..<<<......>>>.....>>>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<<....>>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<.......<<<<<....>>>>>...<<<<<..>>>>>...>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<......>>>>>...>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<..<<<<...<<.<<<<..<<<..<<.....>>.>>>.>>>>.>>..>>>>..>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ ..((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..(..((((....))))..))))......(((.......(((((((..((...(((((((.(.((.....((((((....))))))......)).)........(((((((....)))))))........(((((()))))).)))))))..))))))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....((((((...(.....(((((((........))))))).....)....))))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))...).)))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((((((....)))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((...(....(((((....)))))...(((((..))))))...).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..((......)))))...)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((..((((....(.((((..(((..((.....)).))).)))).)...))))..))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... PoxtA-EQ2 antibiotic resistance ABCF bound to E. faecalis 70S ribosome, state III; 16S rRNA 7p7t b 13 2.9 35387982,30404935 1351 ggagguaugaaaa ............. ............. PoxtA-EQ2 antibiotic resistance ABCF bound to E. faecalis 70S ribosome, state III; mRNA 7p7u A 2824 3.1 RF02540,RF02541,RF00002 URS0002311A01_1351 35387982,30404935 0003735 0005840 1351 uuaagugaauaagggcgcacgguggaugccuuggcacuaggagccgaugaaggacgggacuaacaccgauaugcuuuggggagcuguaaguaagcuaugauccagagauuuccgaaugggggaacccaauaucuuuuauaggauauuacuuuucagugaauacauagcugauuagagguagacgcagagaacugaaacaucuuaguaccugcaggaagagaaagaaaauucgauucccugaguagcggcgagcgaaacgggaagagcccaaaccaacaagcuuguugggguuguaggacuccgauaugguagucuguuaguauaguugaaggauuuggaaaauuccgcuaaagagggugaaagccccguagacgaaaugcugacaacaccuaggaggauccugaguacggcggaacacgagaaauuccgucggaauccgcggggaccaucccgcaaggcuaaauacucccuagugaccgauagugaaccaguaccgugagggaaaggugaaaagcaccccggaaggggagugaaauagauccugaaaccgugugccuacaacaagucaaagcucguuaaugagugauggcgugccuuuuguagaaugaaccggcgaguuacgauugcaugcgagguuaagucgaagagacggagccgcagcgaaagcgagucugaauagggcgaaugaguauguagucguagacccgaaaccaugugaucuacccauguccagguugaaggugcgguaaaacgcacuggaggaccgaacccacguacguugaaaagugcggggaugagguguggguagcggagaaauuccaaacgaacuuggagauagcugguucucuccgaaauagcuuuagggcuagccucggaauugagaaugauggagguagagcacuguuuggacuaggggcccaucucggguuaccgaauucagauaaacuccgaaugccauucauuuauauccgggagucagacugcgagugauaagauccguagucgaaagggaaacagcccagaccaccagcuaaggucccaaaauauauguuaaguggaaaaggaugugggguugcacagacaacuaggauguuggcuuagaagcagccaccauuuaaagagugcguaauagcucacuagucgagugacccugcgccgaaaauguaccggggcuaaacauauuaccgaagcuguggacuacaccauuagguguagugguaggagagcguucuaagggcguugaaggucgaucgugaggacggcuggagcgcuuagaagugagaaugccgguaugaguagcgaaagacaggugagaauccuguccaccguaugacuaagguuuccuggggaaggcucguccgcccaggguuagucgggaccuaagccgaggccgauaggcguaggcgauggacaacagguugauauuccuguaccaguuguuuuuguuugagcaauggagggacgcaguaggcuaaggaaugcaugcgauuggaagugcauguccaagcaaugagucuugaguagaguuaaaugcuuuacucuuuaaggacaaguugugacggggagcgaaauaguagcgaaguuccugacgucacacugccaagaaaagcuucuagugagaaaacaacugcccguaccguaaaccgacacagguagucgaggagaguauccuaaggugagcgagcgaacucucguuaaggaacucggcaaaaugaccccguaacuucgggagaaggggugcugacuucggucagccgcagugaauaggcccaagcgacuguuuaucaaaaacacaggucucugcaaaaucguaagaugaaguauaggggcugacgccugcccggugcuggaagguuaagaggauggguuagcuucggcgaagcucagaauugaagccccaguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgacccgcacgaaaggcguaacgauuugggcacugucucaacgagagacucggugaaauuuuaguaccugugaagaugcagguuacccgcgacaggacggaaagaccccauggagcuuuacuguaguuugauauugaguguuuguaccuguuaugaacccucuaacccgcaccacuaaucguggugggagacagugucagaugggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguucccucagaaugguuggaaaucauucgaagaguguaaaggcagaagggagcuugacugcgagaccuacaagucgagcagggacgaaagucgggcuuagugauccggugguuccgcauggaagggccaucgcucaacggauaaaagcuacccuggggauaacaggcuuaucucccccaagaguccacaucgacggggagguuuggcaccucgaugucggcucgucgcauccuggggcuguagucggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucccuauccgucgcgggcguuggaaauuugagaggagcuguccuuaguacgagaggaccgggauggacuuaccgcugguguaccaguuguucugccaagggcauugcuggguagcuauguagggaagggauaaacgcugaaagcaucuaagugugaagcccaccucaagaugagauuucccauuucuuuaagaaaguaagaccccugagagaugaucagguagauagguuggaaguggaaggcuagugauaguuggagcggaccaauacuaaucggucgaggacuuaac <<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<..<<<<<.........>>>>>..>>.>>....<<<<<......<<....>>.......>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..(((....<<<<<<<..>>>>>>>......<<<<<<<<.....<<<.<<.<<<<<<<<<.<<<...<<<.<......>.>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>..>>>>..>>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<....>>>>..................>>>>>>>>>>>.......<<<<..<<<<......>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>......>>>>>>>>>>>>>..<<.<..<<<<.<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>.>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<.<...<<<<<<<<<.....<<<...<<<<<<<<...<<<<<<<.....>>>>>.>>...>>>>>>>>..>>.>.....>>>>.>>>>>..>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<....>>>>>>>>....>>>>>>..<<<<<<<.<<......<<<<<.<<....>>.>>>>>...>>.>>>>>>>........>>>>>><......<<....<<<<<<.......>>>>>><<<<....<<<<<.<<<..<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<......<<...<<<<....<<<<..<<...<<<<<.<<<<<<...(((....>>>>>><<..<<<<<..<<<<.<<<<<<<<<.....>>>>>>>>>.....>>>>..>>>>>...>>...<<.........>>....>>>>>....>>...>>>>.........>>>>..>>..>>>>>>>>>>>>>>>.>>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<....>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<<.<<....>>..>>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<<.<<<.<<<<<<<.....>>>>>>>.>>>....<<.<<<<<<.....>>>>>>>>.....>>>>>>>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.)))>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<..<<.....<<<<....>>>>....>>...>>>>>.>>>...>>>>....>>>>>>. (.((((......((((((((((.....(((..(((((((((((((......((((((.[[..[[[)))...].((((((...(((]]..]].)))......))))))...)))....(((....)))(((((((......))))))).((..(((((.........)))))..)).))....(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((((((())))))))....{.((((((((.....(((.((.(((((((((.(((...(((.(......).)))[[(...).(((.....]])))...)))...))))))))))))))..))))..)))))....((((((((..[......))))))))....}.(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((..((((..[...))))..)))).<.(.(........).).((((((..(.(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))......)))))))))))))..((.(...(((.((.....((((((((((.((((...((((((......))))))...)<)))...(((.(((((.......A))))))))..).))))))))).(.(((....[)))...).])).)))......).))).((((((....(((((....)))))((((((((....((((((((((.....(((...((((((((...((.((((.....))))..))...))))))))..)).).....)))).))))).).)))))).))..(((((((.((......)).)))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((...(..(((.........)))..).......(...((......)).).)))))...)))))))))).))...........]]].)...))))))))))...)))))))((((((((....))))))))....))))))(.(((((((.((......(((((.((....))])))))...)).)))))))..).....))))))(......((....((((((.......))))))((((....(((...((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((((((((......((...((((....((((..(((..(((((.((((((....{{....))))))((..(((((..((((.(((((((((.....))))))))).....))))..)))))...))...((.........))....)))))...)))...))))(..).....))))..))..))))))))))))))).))).....((......))..))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.[..).....)))))(((((......)))))(...).......(((((((((.>.((.........))...(((((((.....(((....))).......))))))).]((((.(((..(((((((..(((...((...(((((..((....))...)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).[..(((((.....>].)))))..((((((((.(((.((......((((.((((((..(((((.(((((((((.(((.(((((((.(.).))))))).)))....((.((((((.....)))))))).....)))))))))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..a.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((.....))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...))))).). E. faecalis 70S ribosome with P-tRNA, state IV; 23S rRNA 7p7u B 114 3.1 RF00001 URS0000240630_1351 35387982,30404935 0003735 0005840 1351 gugguggcgauagcgagaaggauacaccuguucccaugccgaacacagaaguuaagcuucuuagcgccgauuguagugaaggguuucccuuugugagaguaggacgucgccacg <<<<<<<<....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>..>>>>>>>>. ((((((((....((((((((.....((((((...(.....)...))))..))....)))))).)).((.......((((((((...)))))))).......))..)))))))). E. faecalis 70S ribosome with P-tRNA, state IV; 5S rRNA 7p7u D 77 3.1 RF00005 URS00023119F2_1351 35387982,30404935 0030533 0006412 1351 cgcgggguggagcagucagguagcucgucgggcucauaacccgaaggucguagguucaaauccugcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... E. faecalis 70S ribosome with P-tRNA, state IV; tRNA-fMet 7p7u a 1521 3.1 RF00177,RF01959,RF01960 URS00023358DE_1351 35387982,30404935 0003735 0005840 1351 gagaguuugauccuggcucaggacgaacgcuggcggcgugccuaauacaugcaagucgaacgcuucuuaagaggaguggcggacgggugaguaacacguggguaaccuacccaucagagggggauaacacuuggaaacaggugcuaauaccgcauaacaguuuaugccgcauggcauaagagugaaaggcgcuggugucgcugauggauggacccgcggugcauuagcuaguuggugagguaacggcucaccaaggccacgaugcauagccgaccugagagggugaucggccacacugggacugagacacggcccagacuccuacgggaggcagcaguagggaaucuucggcaauggacgaaagucugaccgagcaacgccgcgugagugaagaagguuuucggaucguaaaacucuguuguuagagaagaacaaggacguuaguaacugaacguccccugacgguaucuaaccagaaagccacggcuaacuacgugccagcagccgcgguaauacguagguggcaagcguuguccggauuuauugggcguaaagcgagcgcaggcgguuucuuaagucugaugugaaagcccccggcucaaccggggagggucauuggaaacugggagacuugagugcagaagaggagaguggaauuccauguguagcggugaaaugcguagauauauggaggaacaccaguggcgaaggcggcucucuggucuguaacugacgcugaggcucgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugagugcuaaguguuggaggguuuccgcccuucagugcugcagcaaacgcauuaagcacuccgccuggggaguacgaccgcaagguugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggucuugacauccuuugaccacucuagagauagagcuuucccuucggggacaaagugacagguggugcaugguugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuuauuguuaguugccaucauuuaguugggcacucuagcgagacugccggugacaaaccggaggaagguggggaugacgucaaaucaucaugccccuuaugaccugggcuacacacgugcuacaaugggaaguacaacgagucgcuagaccgcgaggucaugcaaaucucuuaaagcuucucucaguucggauugcaggcugcaacucgccugcaugaagccggaaucgcuaguaaucgcggaucagcacgccgcggugaauacguucccgggccuuguacacaccgcccgucacaccacgagaguuuguaacacccgaagucggugagguaaccuuuuuggagccagccgccuaaggugggauagaugauuggggugaagucguaacaagguagccguaucggaaggugcggcuggaucaccuccu ..<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<....>>>>.>>>>>......<<........<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<<....>>>>>>......>>.>.......<<<<<<<<....>>>>>>>>.......<<<<<..>>>>>.>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<<<<<<<.........<<<<<<<........>>>>>>>..........>>>>>>...>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<.......<<<<<<.....>>>>>>.....>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<<..<<<......>>>.....>>>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<<....>>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<.......<<<<<....>>>>>...<<<<<..>>>>>...>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<......>>>>>...>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<..<<<<...<<.<<<<..<<<..<<.....>>.>>>.>>>>.>>..>>>>..>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ ..((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..(..((((....))))..))))......(((.......(((((((..((...(((((((.(.((.....((((((....))))))......)).)........(((((((....)))))))........(((((()))))).)))))))..))))))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..(.((((((...(.....(((((((........))))))).....)....))))))....).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))...).)))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((((((....)))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((...(....(((((....)))))...(((((..))))))...).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..((......)))))...)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....))))))))..)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((..((((....(.((((..(((..((.....)).))).)))).)...))))..))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... E. faecalis 70S ribosome with P-tRNA, state IV; 16S rRNA 7p7u b 13 3.1 35387982,30404935 1351 ggagguaugacaa ............. ............. E. faecalis 70S ribosome with P-tRNA, state IV; mRNA 7pah 3 2878 9.5 RF02540,RF02541 URS0000AB9B3C_272634 36171285 0003735 0005840 272634 aguuacuaagggcuuaugguggaugccuuggcacuaauaggcgaugaaggacguguuaaccugcgauaagcuucggguaggugguaagaaccucagauccggagauuuccgaauggagcaauccgguaguuggaaacagcuaucauuaauugaugaauaaauagucaauuaaagcaauacguggugaagugaaacaucucaguagccacaggaaaagaaaacgaaugugauuccguguguaguggcgagcgaaagcggaacaggccaaacuuaucauuagauagggguuguagggcuugcaauguggacuugaaaacgauagaagaagcuguuggaaagcagcgcgcaaaagggugauagccccguauuugaaauuguuuucauaccuagcgagaucccugaguagcucggaaaacguuauuuugagugaaucugcccagaccauuggguaagccuaaauacuaauuagugaccgauagcgaaacaguaccgugagggaaaggugaaaagaacccagagaugggagugaaauagauucugaaaccauaugccuacaacgugucagagcacauuaaugugugauggcgugcguuuugaaguaugagccggcgaguuaugauagcaagcguuaguuaaccaggagauggggagcuguagcgaaagcgaguuuuaaaagagcguuuguuuguuauuauagacccgaaacggguugagcuagucaugagcagguugaagguugaguaacaucaacuggaggaccgaaccgacucucguugaaacgauagcggaugacuugugauuaggggugaaauuccaaucgaaauccgugauagcugguucucgucgaaauagcuuuaaggcuagcgugagaucacaaauaaguggagguaaagcuacugaauguaugauggcgccggcguacugaauacaauuaaacucugaaugccauuuauuuuauucucgcagucagacagugggggauaagcuucauugucaagaggggaagagcccagaucauuaaauaagguccccaaaauauacuaaguggaaaaggaugugaaagugcuaaaacagcaaggauguuggcuuagaagcagccaucguuuaaagagugcguaacagcucacuugucgaguguuuuugcgccgaagauguaacggggcuaaguauauuaccgaauuuauggauaagauuuauaucuugugguagacgagcguuguauuggaguugaagucaaagcgugagcauugguggauccaauacaagugagaaugccggcaugaguaacgcuugggagugagaaucucccaaaccgauugacuaagguuuccuggaccagggucguccuuccaggguuagucuggaccuaagcugaggcugaaaagcguaggcgauggacaacagguuaauauuccuguacuuacaguuagacugauggagugacaaagaagguuuuccacccccauaauuggauuuggggauaaaucauaaggugguacaauaggcaaauccguugugcauaacauugagugaugaugucgagugaaaguagcgaaggugguauuaaucaugcuuucaagaaaagcuucuaggguuaaucuagcuguaaccaguaccgagaacgaacacacguagucaaggagaggauccuaagguuagcgagugaacuauagccaaggaacucugcaaauuaaccccguaaguuagcgagaaggggugcuuauguaaaaguaagccgcagugaagaacgaggggggacuguuuaacuaaaacacaacucuaugccaaaccguaaggugauguauauggggugacaccugcccagugcuggaagguuaaagaaggagguuagcgcaagcgaagcuuuuaacugaagccccagugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuagucggguaaauuccgucccgcuugaaugguguaaccaucucuugacugucucggcuauagacucggugaaauccagguacgggugaagacacccguuaggcgcaacgggacggaaagaccccgugaagcuuuacuguagcuuaauauugaucaggacauuaucauguagagaauagguaggagcaaucgaugcaaguucgcuaggacuuguugaugcgaaagguggaauacuacccuugguugugugcuguucuaauugguaacuguuauccaguuucaagacaguguuaggugggcaguuugacuggggcggucgccuccuaaaagguaacggaggcguacaaagguaccuucaguacgguuggaaaucguauguagaguguaaugguguaagggugcuugacugugagacauacaggucgaacaggugagaaaucaggucauagugauccggugguccaguauggaauggccaucgcucaacggauaaaagcuacuccggggauaacaggcugauacugcccaagaguucauaucgacggcaguguuuggcaccucgaugucgacucaucucauccucgagcugaagcagguucgaaggguucggcuguucgccgauuaaagagauacgugaguuggguucaaaccgucgugagacagguuggucccuaucuauugugcccguaggaagauugaagaguguugcuucuaguacgagaggaccgaagcgaggacaccucuuaugcuccaguuguagcgccagcugcaccgcuggguaguaacgugucuauuagauaaacgcugaaagcaucuaagugugaaacuaucucaaagauuaaucuucccauuucgcaagaaaguaagagccgucaaagacgaugacguugauagguuacagguguaagcauagugauauguugagcugaguaauacuaauugcucgaggacu 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70S ribosome with P- and E-site tRNAs in Mycoplasma pneumoniae cells; 23S ribosomal RNA 7pah 4 105 9.5 RF00001 URS000000E851_272634 36171285 0003735 0005840 272634 uuuggugcccaugucgcuguggaaacaccugguuccauuucgaacccagcaguuaagcacaguggagccgaauguagcugcagugagaauaggaaagcaccaagc <<<<<<<<.....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<..<<...<<....>>....>>.>>...>>>>>>>>. (((((.(.(....((.(((((.....((((((...(.....)...))))..).)...)))))..)).((.......(......).......))...)).))))). 70S ribosome with P- and E-site tRNAs in Mycoplasma pneumoniae cells; 5S ribosomal RNA 7pah 5 1493 9.5 RF00177,RF01959,RF01960 URS00019B76CF_272634 36171285 0003735 0005840 272634 ucugagaguuugauccuggcucaggauuaacgcuggcggcaugccuaauacaugcaagucgaucgaaaguaguaauacuuuagaggcgaacgggugaguaacacguauccaaucuaccuuauaaugggggauaacuaguugaaagacuagcuaauaccgcauaagaacuuugguucgaaucaaaguugaaaggaccugcaaggguucguuauuugaugagggugcgccauaucagcuaguuggugggguaacggccuaccaaggcaaugacguguagcuaugcugagaaguagaauagccacaaugggacugagacacggcccauacuccuacgggaggcagcaguagggaauuuuucacaaugagcgaaagcuugauggagcaaugccgcgugaacgaugaaggucuuuaagauuguaaaguucuuuuauuugggaagaaugacuuuagcagguaauggcuagaguuugacuguaccauuuugaauaagugacgacuaacuaugugccagcagucgcgguaauacauaggucgcaagcguuauccggauuuauugggcguaaagcaagcgcaggcggauugaaaagucugguguuaaaggcagcugcuuaacaguuguaugcauuggaaacuauuaaucuagagugugguagggaguuuuggaauuucauguggagcggugaaaugcguagauauaugaaggaacaccaguggcgaaggcgaaaacuuaggccauuacugacgcuuaggcuugaaaguguggggagcaaauaggauuagauacccuaguaguccacaccguaaacgauagauacuagcugucggggcgauccccucgguagugaaguuaacacauuaaguaucucgccuggguaguacauucgcaagaaugaaacucaaacggaauugacggggacccgcacaagugguggagcauguugcuuaauucgacgguacacgaaaaaccuuaccuagacuugacauccuuggcaaaguuauggaaacauaaugccgagugacagguggugcaugguugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuuaucguuaguuacauugucuagcgagacugcuaaugcaaauuggaggaaggaagggaugacgucaaaucaucaugccccuuaugucuagggcugcaaacgugcuacaauggccaauacaaacagucgccagcuuguaaaagugagcaaaucuguaaaguuggucucaguucggauugagggcugcaauucguccucaugaagucggaaucacuaguaaucgcgaaucagcuaugucgcggugaauacguucucgggucuuguacacaccgcccgucaaacuaugaaagcugguaauauuuaaaaacguguugcuaaccauuaggaagcgcaugucaaggauagcaccggugauuggaguuaagucguaacaagguaccccuacgagaacguggggguggauca .....<<<<..[.((([.>>>>..<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<<<<<....>>>>>>.>>>>>......<<........<<<<<<<..<<...<..<<<<<<.<<.....<<<<<<....>>>>>>......>>.>.....<<<<<<<<......>>>>>>>>....<<<<<<....>>>>>>>>>>>..>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<..[.>>>...>>>>>.>>.<<<<<............>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<.<<.....>>>......>>>>...<...<<<.......<<<<<<<<<........>>>>>>>>>........>>>....>.....<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>........]..<<<((.....<<<<...<<<.<<<<<<..<<<<<<<<<<.....<<<<<<<.....>>>>>>>..>>>>>>>>..>>.>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<<..<<<......>>>.....>>>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<......>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<<.....<<<<....>>>>...>>>>..].))).]<<<<<.<<<<<<<.<<.<<<<<...<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<.<.....<<<<<<....>>>>>>..>.>>.>>.<<<.<<<...<<<<<<<.....<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<.........>>>>>>>.....<<<<<....>>>>>........>>>>.....>>..>>>...>>.>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>....>>>>>>>......<....<<<<<<<........>>>>>>>....>......>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<..<<<<<....<<<<<<.<<<..<<....>>.>>>>>>>>>...>>>>>..>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .....((((..[.[[[..)))).((((..((((..(((((((((....(...(.(..(.(..((.((((((....)))))).))).)......((........((.(.((..((...(..(((.((.((.....(((((......)))))......)).)......(((.....(..).....))).....((((((....))))))).)))..)..)))).).)).(((....((...((.(((((.......)))).))).))......)))..((((((((....))))...))).))).(((((............))))).((((....))))...).)..).).....(.(((...(.(((....)))..))))).)).))))))..((((......(..(.....)..).....))))....(...((...(...(.(((((((........))))))).)...)....))....)......((((([[[...(((((.....((.]]])).......))))))))))..)))).))))..........((([[...(.((((...(((.((((.(..(((((((((......(((.(((.....))).)))...)))))).).)).).))))..((((.((((....(((((((....(((((.(...((........))......).)))))....).......((....)).))))))...))))..)))..))))...))))....((((((...((...((((.........))))...))))))))..........((((((...((..((.((......)).))..))....((..]])).....)))))))))).(.(........((....))......).)....]]].](((((.(((.(((..(...(((...(((.((((((......((........))..........((((.((..(...((.(((.....((((((....))))))..)))..))).((.((....((((((.(....((((((.((....))....(((......)))...)))))).....((.(.(((((((.........)))))))..(..(.(((....))).).....)..).)).....).).)))...))..))))....)).))))...)).)))).))).(...(.((((......(((..(((..(((....))).).))....))).....)))).)......(....(((((((........)))))))....)..)...)))......(((((((..........)))))))......)....))).)))))).))..(.(..((.(.((((.(.(..((.(((..((((.....(((((..(((..((....)).))).)))))....))))..))).))..).).))))..).))...)..)..(((((.(((....))).)))))...... 70S ribosome with P- and E-site tRNAs in Mycoplasma pneumoniae cells; 16S ribosomal RNA 7pah 7 76 9.5 RF00005 URS000054164D_272634 36171285 0030533 0006412 272634 ggucuuguagcucagucgguagagcaacggucugaagaaccgugugucggcaguucgauucugcccgagaccacca <<<<<<...<<<<........>>>>..<<<<.......>>>>......<<<<<.......>>>>>.>>>>>>.... (((.(.(..((((........))))..((((.......))))......(((((.......)))))).).))).... 70S ribosome with P- and E-site tRNAs in Mycoplasma pneumoniae cells; tRNA-Phe 7pah 8 76 9.5 RF00005 URS000054164D_272634 36171285 0030533 0006412 272634 ggucuuguagcucagucgguagagcaacggucugaagaaccgugugucggcaguucgauucugcccgagaccacca <<<<<<...<<<<........>>>>..<<<<.......>>>>......<<<<<.......>>>>>.>>>>>>.... (((.(.(..((((........))))..((((.......))))......(((((.......)))))).).))).... 70S ribosome with P- and E-site tRNAs in Mycoplasma pneumoniae cells; tRNA-Phe 7pai 3 2878 6.7 RF02540,RF02541 URS0000AB9B3C_272634 36171285,36171285 0003735 0005840 272634 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<<<......<<<<.<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>....<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((....<<<<<......>>>>>......<<<<<<<<<...<.<....<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>...>>.>>>>>..>>>>.....<<<<<<<<.......>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<....>>>>..................>>>>>>.>>>>.......<<<<..<<<<......>>>>..>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<...<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<.<<........>>.>>>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<....<<<<<<<<<<.....<.<....<<..<<<<<...<.<......>..>...>>>>>..>>..>..>.....>>>>>>>>>>...>>>>>>..>..<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<....>>>>>>>....>>>>>><<<<<<<<<<<<......<<<<<.<<....>>.>>>>>...>>>>>>>>>>.>>.....>>>>>>.......<<...<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>....<<<<........>>>>.))<<<<<<<<<<<.<...<<<<<...<<<<...<<<..<<<<<<<<<....(((...>>>>><<..<<<<<..<<<<<<<<<<..<<.....>>.>>>>>>....>>>>..>>>>>...>><..<<.......>>...>>>>>....>>>....>>>>........>>>>>..>......>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<<...<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<......>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<..<<<<<<..<<....>>...>>>>>>..>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<.<<<.......>>>.>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>>>>>>>>...........<<<<<........>>>>>..<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<<.<<.<<<.<<<<..<<<...........<<<<<..<<<......<<<<<<<......>>>>>>>...>>>.............>>>>>..>>>..>>>>.>>>.>>...<<<..<<<<<.....>>>>>.>>>....>>>>>>>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>........[.(((......>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.........<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.......<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<<....<<<...<<<<<<...............>>>>>>.<<<<<<...<<<<...<<<<<<<<<<<.)))>>>>>>..>>>>>...>>>>.>>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>........>>>>>>>..................<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> 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70S ribosome with P-site tRNA in Mycoplasma pneumoniae cells; 23S ribosomal RNA 7pai 4 105 6.7 RF00001 URS000000E851_272634 36171285,36171285 0003735 0005840 272634 uuuggugcccaugucgcuguggaaacaccugguuccauuucgaacccagcaguuaagcacaguggagccgaauguagcugcagugagaauaggaaagcaccaagc <<<<<<<<.....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<..<....<<<..>>>.....>.>>...>>>>>>>>. ..((((((.....((.(((((.....((((((...(.....)...))))..))....)))))..)).((......................))...))))))... 70S ribosome with P-site tRNA in Mycoplasma pneumoniae cells; 5S ribosomal RNA 7pai 5 1493 6.7 RF00177,RF01959,RF01960 URS00019B76CF_272634 36171285,36171285 0003735 0005840 272634 ucugagaguuugauccuggcucaggauuaacgcuggcggcaugccuaauacaugcaagucgaucgaaaguaguaauacuuuagaggcgaacgggugaguaacacguauccaaucuaccuuauaaugggggauaacuaguugaaagacuagcuaauaccgcauaagaacuuugguucgaaucaaaguugaaaggaccugcaaggguucguuauuugaugagggugcgccauaucagcuaguuggugggguaacggccuaccaaggcaaugacguguagcuaugcugagaaguagaauagccacaaugggacugagacacggcccauacuccuacgggaggcagcaguagggaauuuuucacaaugagcgaaagcuugauggagcaaugccgcgugaacgaugaaggucuuuaagauuguaaaguucuuuuauuugggaagaaugacuuuagcagguaauggcuagaguuugacuguaccauuuugaauaagugacgacuaacuaugugccagcagucgcgguaauacauaggucgcaagcguuauccggauuuauugggcguaaagcaagcgcaggcggauugaaaagucugguguuaaaggcagcugcuuaacaguuguaugcauuggaaacuauuaaucuagagugugguagggaguuuuggaauuucauguggagcggugaaaugcguagauauaugaaggaacaccaguggcgaaggcgaaaacuuaggccauuacugacgcuuaggcuugaaaguguggggagcaaauaggauuagauacccuaguaguccacaccguaaacgauagauacuagcugucggggcgauccccucgguagugaaguuaacacauuaaguaucucgccuggguaguacauucgcaagaaugaaacucaaacggaauugacggggacccgcacaagugguggagcauguugcuuaauucgacgguacacgaaaaaccuuaccuagacuugacauccuuggcaaaguuauggaaacauaaugccgagugacagguggugcaugguugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuuaucguuaguuacauugucuagcgagacugcuaaugcaaauuggaggaaggaagggaugacgucaaaucaucaugccccuuaugucuagggcugcaaacgugcuacaauggccaauacaaacagucgccagcuuguaaaagugagcaaaucuguaaaguuggucucaguucggauugagggcugcaauucguccucaugaagucggaaucacuaguaaucgcgaaucagcuaugucgcggugaauacguucucgggucuuguacacaccgcccgucaaacuaugaaagcugguaauauuuaaaaacguguugcuaaccauuaggaagcgcaugucaaggauagcaccggugauuggaguuaagucguaacaagguaccccuacgagaacguggggguggauca .....<<<<..[.(((..>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<<<<<....>>>>>>.>>>>>......<<........<<<<<<<..<<...<..<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<<<<<<......>>>>>>>>....<<<<<<....>>>>>>.>>>>..>..>>>>>>>>>.<<.....<<<..<<<<<<<<.......>>>>>>>>>>>.......>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>......<..<<<....<<<<....>>>>..>>>.>>>.>>>>>>..<<<<.......<<<.....>>>......>>>>...<<..<<<.......<.<<<<<<<........>>>>>>>.>........>>>...>>.....<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<..<<<<<<<<<<.....<<<<<<<.....>>>>>>>..>>>>>>>>..>>.>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<<..<<<......>>>.....>>>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<......>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<.....<<<<<....>>>>>...>>>....))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<.<<<<.....<<<<<......>>>>>..>>>>.>..<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<.........>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<..<<<<<....<<<<<.<<<<..<<....>>.>>>>>>>>>...>>>>>..>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((......(.(..((.((((((....)))))).))).)......(((........(((.((..((...(..((((.(.((.....(((((......)))))......)).).....(((((((........)))))))....((((((....)))))).))))..)..)))).)))..((.....((...(.(((.((.......)).))).).)).......))..(((((.((....)).)...))))))).(((((............))))).((((....))))......))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((.....)))).....))))....(...((...(.....((.((((........)))).)).....)....))....)......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.((((.(..((.((..((......(((((((.....)))))))...))..))...)).).))))..((((.(((.....(((((((....(((((((...((........))......)))))))....).......((....)).))))))....)))..)))..))))...))))....((((((...((...((((.........))))...))))))))......{...(((.((...((((((.((......)).))))))....((..]])).....)).))))))).(((.......(((....))).....)))....]]].]((.((.((..(((.((..(...(..(((((((.(.......((........))..........(((((((..(....((((((.....((..(....)..))..))))).).).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((.(((.........))).)))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))....)..))))))).(...((((((......(((..(((.((((....))))).))....))).....))))))......(....(((((((........)))))))....)..)..)...).....(((((((..........)))))))......))...)))..))))..))..(.(..((.(.((((.(.(..((((((..(((.(....((((((.(((..((....)).)))))))))...).)))..))))))..).).))))..).))...)..)..(((((((((....)))))))))}..... 70S ribosome with P-site tRNA in Mycoplasma pneumoniae cells; 16S ribosomal RNA 7pai 7 76 6.7 RF00005 URS000054164D_272634 36171285,36171285 0030533 0006412 272634 ggucuuguagcucagucgguagagcaacggucugaagaaccgugugucggcaguucgauucugcccgagaccacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((.(..((((........))))..((((.......))))......(((((.......)))))).))))).... 70S ribosome with P-site tRNA in Mycoplasma pneumoniae cells; tRNA-Phe 7paj 3 2878 7.3 RF02540,RF02541 URS0000AB9B3C_272634 36171285 0003735 0005840 272634 aguuacuaagggcuuaugguggaugccuuggcacuaauaggcgaugaaggacguguuaaccugcgauaagcuucggguaggugguaagaaccucagauccggagauuuccgaauggagcaauccgguaguuggaaacagcuaucauuaauugaugaauaaauagucaauuaaagcaauacguggugaagugaaacaucucaguagccacaggaaaagaaaacgaaugugauuccguguguaguggcgagcgaaagcggaacaggccaaacuuaucauuagauagggguuguagggcuugcaauguggacuugaaaacgauagaagaagcuguuggaaagcagcgcgcaaaagggugauagccccguauuugaaauuguuuucauaccuagcgagaucccugaguagcucggaaaacguuauuuugagugaaucugcccagaccauuggguaagccuaaauacuaauuagugaccgauagcgaaacaguaccgugagggaaaggugaaaagaacccagagaugggagugaaauagauucugaaaccauaugccuacaacgugucagagcacauuaaugugugauggcgugcguuuugaaguaugagccggcgaguuaugauagcaagcguuaguuaaccaggagauggggagcuguagcgaaagcgaguuuuaaaagagcguuuguuuguuauuauagacccgaaacggguugagcuagucaugagcagguugaagguugaguaacaucaacuggaggaccgaaccgacucucguugaaacgauagcggaugacuugugauuaggggugaaauuccaaucgaaauccgugauagcugguucucgucgaaauagcuuuaaggcuagcgugagaucacaaauaaguggagguaaagcuacugaauguaugauggcgccggcguacugaauacaauuaaacucugaaugccauuuauuuuauucucgcagucagacagugggggauaagcuucauugucaagaggggaagagcccagaucauuaaauaagguccccaaaauauacuaaguggaaaaggaugugaaagugcuaaaacagcaaggauguuggcuuagaagcagccaucguuuaaagagugcguaacagcucacuugucgaguguuuuugcgccgaagauguaacggggcuaaguauauuaccgaauuuauggauaagauuuauaucuugugguagacgagcguuguauuggaguugaagucaaagcgugagcauugguggauccaauacaagugagaaugccggcaugaguaacgcuugggagugagaaucucccaaaccgauugacuaagguuuccuggaccagggucguccuuccaggguuagucuggaccuaagcugaggcugaaaagcguaggcgauggacaacagguuaauauuccuguacuuacaguuagacugauggagugacaaagaagguuuuccacccccauaauuggauuuggggauaaaucauaaggugguacaauaggcaaauccguugugcauaacauugagugaugaugucgagugaaaguagcgaaggugguauuaaucaugcuuucaagaaaagcuucuaggguuaaucuagcuguaaccaguaccgagaacgaacacacguagucaaggagaggauccuaagguuagcgagugaacuauagccaaggaacucugcaaauuaaccccguaaguuagcgagaaggggugcuuauguaaaaguaagccgcagugaagaacgaggggggacuguuuaacuaaaacacaacucuaugccaaaccguaaggugauguauauggggugacaccugcccagugcuggaagguuaaagaaggagguuagcgcaagcgaagcuuuuaacugaagccccagugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuagucggguaaauuccgucccgcuugaaugguguaaccaucucuugacugucucggcuauagacucggugaaauccagguacgggugaagacacccguuaggcgcaacgggacggaaagaccccgugaagcuuuacuguagcuuaauauugaucaggacauuaucauguagagaauagguaggagcaaucgaugcaaguucgcuaggacuuguugaugcgaaagguggaauacuacccuugguugugugcuguucuaauugguaacuguuauccaguuucaagacaguguuaggugggcaguuugacuggggcggucgccuccuaaaagguaacggaggcguacaaagguaccuucaguacgguuggaaaucguauguagaguguaaugguguaagggugcuugacugugagacauacaggucgaacaggugagaaaucaggucauagugauccggugguccaguauggaauggccaucgcucaacggauaaaagcuacuccggggauaacaggcugauacugcccaagaguucauaucgacggcaguguuuggcaccucgaugucgacucaucucauccucgagcugaagcagguucgaaggguucggcuguucgccgauuaaagagauacgugaguuggguucaaaccgucgugagacagguuggucccuaucuauugugcccguaggaagauugaagaguguugcuucuaguacgagaggaccgaagcgaggacaccucuuaugcuccaguuguagcgccagcugcaccgcuggguaguaacgugucuauuagauaaacgcugaaagcaucuaagugugaaacuaucucaaagauuaaucuucccauuucgcaagaaaguaagagccgucaaagacgaugacguugauagguuacagguguaagcauagugauauguugagcugaguaauacuaauugcucgaggacu <<<......<<<<.<<<<<<....<<<..<<<<<<<<<<<<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>....<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<....<<<<<<....>>>>>>......<<<<<<<<<..........<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>......>>>>>..>>>>.....<<<<<<<<.......>>>>>>>>.......<<<<..<<<<>>>>...>>>......>>.>>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>.............>....>>>>>>.>>>>.......<<<<..<<<<......>>>>..>>>>...<<..........>>.<<<<<<....<<<<<<<<<<<<<...<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<.<<........>>.>>>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<....<<<<<<<<<<............<<<.<<<<....<.<<....>>..>....>>>>.>>>...........>>>>>>>>>>...>>>>>>.>>..<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((...<<<<<<<...........<<..<<<<<<<.<........<<<<<.<<...<<<.........>>>...>>.........<<......>>...>>>>>....>.>>>>>>>.>>...........))).....>>>>>>>>>>...>>>>>>><<<<<<<....>>>>>>>....>>>>>><<<<<<<<<<<<......<<<<<.<<....>>.>>>>>...>>>>>>>>>>.>>.....>>>>>>.......<<...<<<<<<.......>>>>>>.<<<....<<<<<.<<<..<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<.<...<<<<<...<<<<..<<<<..<<<<<<<<<.....[[...>>>>><...<<<<<..<<<<<<<<<<<.<<.....>>>>>>>>>....>>>>..>>>>>....><..<<.......>>...>>>>>....>>>>...>>>>........>>>>>..>......>>>>>>>>>>>>>>>.>>>.....<<......>>>>>>>.<<<<.....>>>>..>>>...<<<<<...<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<......>>>>>>............<<<<<<<<<...<<.........>>...<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<..<<<<<<<.<<....>>..>>>>>>>..>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<.............<<<.......>>>.......>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>>>>>>>>...........<<<<<........>>>>>..<<<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<..<<.<<<.<<<<.<<<<...........<<<<<..<<.......<<<<<<<......>>>>>>>....>>.............>>>>>..>>>>.>>>>.>>>.>>...<<<..<<<<<.....>>>>>.>>>.....>>>>>>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>..........(((......>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..>>>>..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>........<<<<..<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>......>>>.>.....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>>>....<<<<<<<....<<<..<<<<<<<...............>>>>>>><<<<<<...<<<<...<<<<<<<<<<<.]].>>>>>>..>>>>>...>>>>.>>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>........>>>>>>>..<.........>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (..(.....((((.(((((.....(((..(((((((((((((......(((((.....[[[..))....(((.(((...(((]]]....)))......))).)).).)))....(((....)))(.((((((....)))))).).(((((((((.........))))))))).))....(((((......(...[..).......))))..)........((....))...((((......((.]...)).....))))...((((...(((((......)))))......(((((((((......(...(((((((.((..((...(((((......)))))[[......(((.....]])))...))....)).)))))))..)...)))))..)))))....(((((.(((.[..).)).))))).......((((].[[[[))))...)))......)).))))))).))...............((....))....)).........((((....)))).............).....))))).)))).....(.(.((..((((..[...))))..)).).<.(((........))).((((((....(((((((.(((.(....(....(((.....)))....)....((....))..(.((.....)).)....).))).)))))))..((.(...((((((.....(((((.((((.((((....(((((......)))))....).)))...(((.((.((........)).)))))..).))).))))).(.((.......))...)..))))))......).))..((((((....(((((....)))))((((((((....((((((((((.....(.(....(((.(((((...(.((....))..)...))))).)))...).).....))))))))))...)))))).))..((((.((..(......)..)).))))....(((......)))....(((.(((...((([[[...(((((((.....(.....((..(..(((...........(((((.(((..(((.........)))..))).....(...((......)).).))))).......)))..).))...........]]].)...))))))))))...)))))).(.(((((....))))).)....))))))(.(((((..(((........(((.((....))])).)....)))..)))))..).....)))))).......((...((((((.......))))))(.((....(((.......(((((((...((.....)).))))))....[[((((.((.(.((....(((....)))....))..)))...(((((........)))))]](((((((((((((...(.(((...((((..((((..((((((((..(...{{..).))))(...(((((..(((((.((((..((.....)).)))).)....))))..)))))....)(..((.......))...)))))....))))...))))(..)....))).)...))....))))))))))))))).).......((......))..))).((((.....))))..)).)..((((....((((((((.((..(....(.......(((((....(.[..).....)))))((((((......))))))(...).......(.((.(.((...((.........))...((((.((.....(((....))).......)).)))).]((((.(((..((.((((..(((...((...((((...((....))....))))...))...)))))))...)))))(.(((.........))).)........((..........(.((.(......))).)..)..)....))))...))..).)).).)..))).)))))))).))))))......).[..(((((.....>].)))))..(((((((..(((.((......((((.((((((..(((((.(((((((((.((.(((.((((.((((.(......[..(((((..(((.......(((((.(....).)))))....)))...........].)))))).))).))))).))).))...(((..(((((.....))))).)))....)))))))))..)))))..(((......[)))((((((..........]))))))(..(...((.((((.(..((((.........))))....)....[.[[[......)))).).)..((((..(((...{..)))..)))).(((....))).).]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......((((.((((((..((.(((.((......)).)))...)).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....))..))).)))))))[...(((((((....(((..(.(((((.....(....)....))))).).(((((...((((...((((.((((((.}}.))))))...))))...)))).)))))...(((....((((.............))))....))).)))...]....)))))))(...(.......).....(((((((((.......)))))....(((.((((.((.....(((((....)))))....))..))))..)))...))))...)).) 70S ribosome with EF-Tu-tRNA, P- and E-site tRNAs in Mycoplasma pneumoniae cells; 23S ribosomal RNA 7paj 4 105 7.3 RF00001 URS000000E851_272634 36171285 0003735 0005840 272634 uuuggugcccaugucgcuguggaaacaccugguuccauuucgaacccagcaguuaagcacaguggagccgaauguagcugcagugagaauaggaaagcaccaagc <<<<<<<<.....<<<<<<<<.....<<<<<<.............>>>>..>>....>>>>>>.>>.<<.......<<<..>>>.......>>...>>>>>>>>. .(((((((.....((((((((.....((((((...(.....)...))))..))....)))))).)).((.......(......).......))...))))))).. 70S ribosome with EF-Tu-tRNA, P- and E-site tRNAs in Mycoplasma pneumoniae cells; 5S ribosomal RNA 7paj 5 1493 7.3 RF00177,RF01959,RF01960 URS00019B76CF_272634 36171285 0003735 0005840 272634 ucugagaguuugauccuggcucaggauuaacgcuggcggcaugccuaauacaugcaagucgaucgaaaguaguaauacuuuagaggcgaacgggugaguaacacguauccaaucuaccuuauaaugggggauaacuaguugaaagacuagcuaauaccgcauaagaacuuugguucgaaucaaaguugaaaggaccugcaaggguucguuauuugaugagggugcgccauaucagcuaguuggugggguaacggccuaccaaggcaaugacguguagcuaugcugagaaguagaauagccacaaugggacugagacacggcccauacuccuacgggaggcagcaguagggaauuuuucacaaugagcgaaagcuugauggagcaaugccgcgugaacgaugaaggucuuuaagauuguaaaguucuuuuauuugggaagaaugacuuuagcagguaauggcuagaguuugacuguaccauuuugaauaagugacgacuaacuaugugccagcagucgcgguaauacauaggucgcaagcguuauccggauuuauugggcguaaagcaagcgcaggcggauugaaaagucugguguuaaaggcagcugcuuaacaguuguaugcauuggaaacuauuaaucuagagugugguagggaguuuuggaauuucauguggagcggugaaaugcguagauauaugaaggaacaccaguggcgaaggcgaaaacuuaggccauuacugacgcuuaggcuugaaaguguggggagcaaauaggauuagauacccuaguaguccacaccguaaacgauagauacuagcugucggggcgauccccucgguagugaaguuaacacauuaaguaucucgccuggguaguacauucgcaagaaugaaacucaaacggaauugacggggacccgcacaagugguggagcauguugcuuaauucgacgguacacgaaaaaccuuaccuagacuugacauccuuggcaaaguuauggaaacauaaugccgagugacagguggugcaugguugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuuaucguuaguuacauugucuagcgagacugcuaaugcaaauuggaggaaggaagggaugacgucaaaucaucaugccccuuaugucuagggcugcaaacgugcuacaauggccaauacaaacagucgccagcuuguaaaagugagcaaaucuguaaaguuggucucaguucggauugagggcugcaauucguccucaugaagucggaaucacuaguaaucgcgaaucagcuaugucgcggugaauacguucucgggucuuguacacaccgcccgucaaacuaugaaagcugguaauauuuaaaaacguguugcuaaccauuaggaagcgcaugucaaggauagcaccggugauuggaguuaagucguaacaagguaccccuacgagaacguggggguggauca .....<<<<....(((..>>>>.<<<<.<<<<<..<<<<<<<<.<<..<<<.<<<..<<<..<<.<<<<<<....>>>>>>.>>>>>......<<........<<<.<<<..<<......<<<<<<.<<.....<<<<<<....>>>>>>......>>.>.....<<<<<<<<......>>>>>>>>....<<<<<<....>>>>>>>>>>>.....>>>>>.>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>...>>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>>....<<.<<<....<<<<....>>>>..>>>>>>>.>>>>>>..<<<<.......<<<.....>>>......>>>>...<<..<<<.......<<<<<<<<<........>>>>>>>>>........>>>...>>.....<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<..<<<<<<<<<<.....<<<<<<<.....>>>>>>>..>>>>>>>>..>>.>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<<..<<<......>>>.....>>>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<......>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<.....<<<<<....>>>>>...>>>....)))..<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<.....<<.<<<....>>>.>>..>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<.........>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>....>>>>>>>......<..<<.<<<<<<........>>>>>>>>...>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<..<<<<<....<<<<<.<<<<..<<....>>.>>>>>>>>>...>>>>>..>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .....[[[.....(((...]]]..(.(.(((((..(((((((((....(((.(((..(.(..((.((((((....)))))).))).)......(((.......((((.((..((...(...(((((.((.....(((((......)))))......)).).....(..((((..(..)..))))..)....(.((((....)))).)))))...)..)))).)))).((.....(((..(((((.((.......)).)))))))).......))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(..((...(.(((....)))..))).).)).))))))..((((......((((.....)))).....))))....(..(((...(...(..(.((((........)))).)...)..)....)))...)......(.((([[[...(((((.....((.]]])).......)))))))).)..))))))..)..........((([[...(.((((....((.((((.(..(((((..(((.....(((.(((.....))).)))..)))..)))..)).).))))..((((.((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))))..)))..)))....))))....((((((...((...((((.........))))...))))))))......{...((((((..((((.((.((......)).)).))))...((..]])).....)))))))))).(.(.......(((....))).....).)....)))..(((((.(((((((.((..(((.(..((((((((((......((........))..........(((((((..(.....(((((........((....)).....)))))...).((.((....((((((.(....((((((.((....))....(((......)))...)))))).....((((.(((.(((.........))).)))..(..(((((....))))).....)..)))).....).).)))...))..))))....)))))))...)).)))))))).(...(((((((.....(((..(((..(((....))).).))....)))....)))))))......(....(((((.(........).)))))....)..)..).))).....(((((((..........)))))))......))...)))))))))).))..(.(..((.(.((((..((..((((((..((((.....(((((..(((..((....)).))).)))))....))))..))))))..))..))))..).))...)..)..(((((((((....)))))))))}..... 70S ribosome with EF-Tu-tRNA, P- and E-site tRNAs in Mycoplasma pneumoniae cells; 16S ribosomal RNA 7paj 6 76 7.3 RF00005 URS000054164D_272634 36171285 0030533 0006412 272634 ggucuuguagcucagucgguagagcaacggucugaagaaccgugugucggcaguucgauucugcccgagaccacca <<<<<<...<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>.>>>>>>.... (((((((..((((........))))..((((.......))))......(((((.......)))))))))))).... 70S ribosome with EF-Tu-tRNA, P- and E-site tRNAs in Mycoplasma pneumoniae cells; tRNA-Phe 7paj 7 76 7.3 RF00005 URS000054164D_272634 36171285 0030533 0006412 272634 ggucuuguagcucagucgguagagcaacggucugaagaaccgugugucggcaguucgauucugcccgagaccacca <<<<<<...<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>.>>>>>>.... (((((((..((((........))))..((((.......))))......(((((.......)))))))))))).... 70S ribosome with EF-Tu-tRNA, P- and E-site tRNAs in Mycoplasma pneumoniae cells; tRNA-Phe 7paj 8 76 7.3 RF00005 URS000054164D_272634 36171285 0030533 0006412 272634 ggucuuguagcucagucgguagagcaacggucugaagaaccgugugucggcaguucgauucugcccgagaccacca <<<<<<...<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>.>>>>>>.... (((((((..((((........))))..((((.......))))......(((((.......)))))))))))).... 70S ribosome with EF-Tu-tRNA, P- and E-site tRNAs in Mycoplasma pneumoniae cells; tRNA-Phe 7pak 3 2878 5.3 RF02540,RF02541 URS0000AB9B3C_272634 36171285,36171285 0003735 0005840 272634 aguuacuaagggcuuaugguggaugccuuggcacuaauaggcgaugaaggacguguuaaccugcgauaagcuucggguaggugguaagaaccucagauccggagauuuccgaauggagcaauccgguaguuggaaacagcuaucauuaauugaugaauaaauagucaauuaaagcaauacguggugaagugaaacaucucaguagccacaggaaaagaaaacgaaugugauuccguguguaguggcgagcgaaagcggaacaggccaaacuuaucauuagauagggguuguagggcuugcaauguggacuugaaaacgauagaagaagcuguuggaaagcagcgcgcaaaagggugauagccccguauuugaaauuguuuucauaccuagcgagaucccugaguagcucggaaaacguuauuuugagugaaucugcccagaccauuggguaagccuaaauacuaauuagugaccgauagcgaaacaguaccgugagggaaaggugaaaagaacccagagaugggagugaaauagauucugaaaccauaugccuacaacgugucagagcacauuaaugugugauggcgugcguuuugaaguaugagccggcgaguuaugauagcaagcguuaguuaaccaggagauggggagcuguagcgaaagcgaguuuuaaaagagcguuuguuuguuauuauagacccgaaacggguugagcuagucaugagcagguugaagguugaguaacaucaacuggaggaccgaaccgacucucguugaaacgauagcggaugacuugugauuaggggugaaauuccaaucgaaauccgugauagcugguucucgucgaaauagcuuuaaggcuagcgugagaucacaaauaaguggagguaaagcuacugaauguaugauggcgccggcguacugaauacaauuaaacucugaaugccauuuauuuuauucucgcagucagacagugggggauaagcuucauugucaagaggggaagagcccagaucauuaaauaagguccccaaaauauacuaaguggaaaaggaugugaaagugcuaaaacagcaaggauguuggcuuagaagcagccaucguuuaaagagugcguaacagcucacuugucgaguguuuuugcgccgaagauguaacggggcuaaguauauuaccgaauuuauggauaagauuuauaucuugugguagacgagcguuguauuggaguugaagucaaagcgugagcauugguggauccaauacaagugagaaugccggcaugaguaacgcuugggagugagaaucucccaaaccgauugacuaagguuuccuggaccagggucguccuuccaggguuagucuggaccuaagcugaggcugaaaagcguaggcgauggacaacagguuaauauuccuguacuuacaguuagacugauggagugacaaagaagguuuuccacccccauaauuggauuuggggauaaaucauaaggugguacaauaggcaaauccguugugcauaacauugagugaugaugucgagugaaaguagcgaaggugguauuaaucaugcuuucaagaaaagcuucuaggguuaaucuagcuguaaccaguaccgagaacgaacacacguagucaaggagaggauccuaagguuagcgagugaacuauagccaaggaacucugcaaauuaaccccguaaguuagcgagaaggggugcuuauguaaaaguaagccgcagugaagaacgaggggggacuguuuaacuaaaacacaacucuaugccaaaccguaaggugauguauauggggugacaccugcccagugcuggaagguuaaagaaggagguuagcgcaagcgaagcuuuuaacugaagccccagugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuagucggguaaauuccgucccgcuugaaugguguaaccaucucuugacugucucggcuauagacucggugaaauccagguacgggugaagacacccguuaggcgcaacgggacggaaagaccccgugaagcuuuacuguagcuuaauauugaucaggacauuaucauguagagaauagguaggagcaaucgaugcaaguucgcuaggacuuguugaugcgaaagguggaauacuacccuugguugugugcuguucuaauugguaacuguuauccaguuucaagacaguguuaggugggcaguuugacuggggcggucgccuccuaaaagguaacggaggcguacaaagguaccuucaguacgguuggaaaucguauguagaguguaaugguguaagggugcuugacugugagacauacaggucgaacaggugagaaaucaggucauagugauccggugguccaguauggaauggccaucgcucaacggauaaaagcuacuccggggauaacaggcugauacugcccaagaguucauaucgacggcaguguuuggcaccucgaugucgacucaucucauccucgagcugaagcagguucgaaggguucggcuguucgccgauuaaagagauacgugaguuggguucaaaccgucgugagacagguuggucccuaucuauugugcccguaggaagauugaagaguguugcuucuaguacgagaggaccgaagcgaggacaccucuuaugcuccaguuguagcgccagcugcaccgcuggguaguaacgugucuauuagauaaacgcugaaagcaucuaagugugaaacuaucucaaagauuaaucuucccauuucgcaagaaaguaagagccgucaaagacgaugacguugauagguuacagguguaagcauagugauauguugagcugaguaauacuaauugcucgaggacu <<<......<<<<.<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>....<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...(((.....<<<<......>>>>.......<<<<<<<<<..........<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>......>>>>>..>>>>.....<<<<<<<<.......>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<....>>>>.............}....>>>>>>.>>>>.......<<<<..<<<<......>>>>..>>>>...<<..........>>.<<<<<<....<<<<<<<<<<<<....<<.<..<<<.....>>>...>>>...<<....>>..<<<<<...>>>>>.....>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<.<<........>>.>>>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<....<<<<<<<<<<......<<....<<..<<<<<...<..<....>...>...>>>>>..>>..>>.......>>>>>>>>>>...>>>>>>.>>..<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((....<<<<<<...........<<...<<<<<<...........<<<<..<...<<<.........>>>...>..........<<......>>...>>>>.......>>>>>>..>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<......>>>>>>....>>>>>><<<<<<<<<<<<......<<<<<.<<....>>.>>>>>...>>>>>>>>>>.>>.....>>>>>>.......<<...<<<<<<.......>>>>>><<<.....<<<<<.<<<..<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>....<<<<........>>>>.))<<<<<<<<<<<.<...<<<<<....<<<...<<<..<<<<<<<<<.....[[...>>>>><...<<<<<..<<<<<<<<<<..<<.....>>.>>>>>>....>>>>..>>>>>....><..<<.......>>...>>>>>....>>>.....>>>........>>>>>..>......>>>>>>>>>>>>>>>.>>>.....<<......>>>>>>>.<<<<.....>>>>...>>>..<<<<<...<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<......>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<..<<..<<<<<<..<<....>>...>>>>>>..>>..>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<.<<<.......>>>.>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>>>>>>>>...........<<<<<........>>>>>..<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<<.<<.<<<.<<....<<<...........<<<<....<...........<<........>>........>...............>>>>..>>>....>>.>>>.>>...<<<..<<<<<.....>>>>>.>>>....>>>>>>>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>........<<<<..<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>......>>>.>.....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<<....<<<...<<<<<<...............>>>>>>.<<<<<<...<<<<...<<<<<<<<<<<.]].>>>>>>..>>>>>...>>>>.>>>>>><.<<<....<<<<<...........>>>>>....>>>>>>>........>>>>>>>..................<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> .........((((.(((((.....(((..((((((.((((((......((((((....[[[.))).....((.(((...(((]]]....)))......))).))...)))....(((....)))((((((((....))))))))..((((((((.........))))))))..))....((((((.....(...[..)......))))).).........((....))....((((.....((.]...))....))))....((((.(.(((((......)))))..)...(((((((((..........(((((.((((.(((...((((........))))[[......(((.....]])))...)))...)))).)))))......)))))..)))))....((((..(((.[..).))..))))......(((((]..[[[)))))..)))......)).)).)))).))...............((....))....)).........((((....)))).............).....))))).)))).....(.((((..((((..[...))))..)))).<.(.(........).).((((((....(((((((((((.(....(.(..(((.....)))...))....((....))..((((.....))))....).)))))))))))..((.(...((((((.....(((((..(((.((((...((((((......))))))...).)))...(((.((.((........)).)))))..).))..))))).(.((.......))...)..))))))......).))..((((((....((((......))))..((((((....((.(((((((.....(((....(((.(((((...(...........)...))))).)))..)).).....))))))).))...)))))).....((((((((.(......).))))))))....(((......)))....(((.(((...((([[[...((((.((.....(.....((..(..((.(........{..((((.(.(..(((.........)))..)..)....(...((......)).).))))........)))..).))...........]]].)...)).)))))))...)))))).(((((........)))))....))))))(((((((.((((......(.(.(.((....))].)).)...)))).))))).)).....)))))).......((...((((.(.......).))))((((....(((...(...(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]]((((((((((((....(..(....((((..((((.....((((((.....{{...)))))(...(((((..(.((..(((.(.((.....))).)))......)).)..)))))....)(..((.......))...)).......))))...))))(..)......).)....)....))))))))))))))).).).....((......))..))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.[..).....)))))((((((......))))))(...).......((((.(.((...((.........))...(((((((.....(((....))).......))))))).]((((.(((..(((((((..(((...((....(.((..((....))...)).)....))...))))))))..)))))(((((.........)))))........((..........(.(((.......))).)..)..)....))))...))..).)))).)..))).)))))))).))))))......).[..(((((.....>].)))))..(((((((..(((.((......((((.((((((..(.(((.(((((((...((.(((.((.....((........[..(((.(..((........(..(..........)..).....))...........].).)))..)).....)).))).))...(((..(.(((.....))).).)))......)))))))..)))..).(((......[)))((((((..........]))))))(.((...(((((((.(.(((((.........)))))...).((...[[[))....)))))).)..((((..(((...{..)))..)))).(((....))).))]]].......(((.(((.((..]]]...))))).))).....)}......))))..))))))......((((..(..(((((...((.......))...)))))....).)).).)......((((..(((((..((((((((........)))))..))).(((((.....))))).....)))))......))).).....(((((((....))).))))....))..))).)))))))[...(((((......(((..(((((((.....(....)....))))))).(((((...((.....(((((((((((.}}.))))))..))))).....)).)))))...(((....((((.....}.......))))....))).)))...]......)))))(.................(((((((((.......)))))....(((.((((.((......((((....)))).....))..))))..)))...))))...)... 70S ribosome with EF-Tu-tRNA and P-site tRNA in Mycoplasma pneumoniae cells; 23S ribosomal RNA 7pak 4 105 5.3 RF00001 URS000000E851_272634 36171285,36171285 0003735 0005840 272634 uuuggugcccaugucgcuguggaaacaccugguuccauuucgaacccagcaguuaagcacaguggagccgaauguagcugcagugagaauaggaaagcaccaagc <<<<<<<<.....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<..<....<<<..>>>.....>.>>...>>>>>>>>. .((((.(......((((((((.....((((((...(.....)...))))..))....)))))).))..(......................).....).)))).. 70S ribosome with EF-Tu-tRNA and P-site tRNA in Mycoplasma pneumoniae cells; 5S ribosomal RNA 7pak 5 1493 5.3 RF00177,RF01959,RF01960 URS00019B76CF_272634 36171285,36171285 0003735 0005840 272634 ucugagaguuugauccuggcucaggauuaacgcuggcggcaugccuaauacaugcaagucgaucgaaaguaguaauacuuuagaggcgaacgggugaguaacacguauccaaucuaccuuauaaugggggauaacuaguugaaagacuagcuaauaccgcauaagaacuuugguucgaaucaaaguugaaaggaccugcaaggguucguuauuugaugagggugcgccauaucagcuaguuggugggguaacggccuaccaaggcaaugacguguagcuaugcugagaaguagaauagccacaaugggacugagacacggcccauacuccuacgggaggcagcaguagggaauuuuucacaaugagcgaaagcuugauggagcaaugccgcgugaacgaugaaggucuuuaagauuguaaaguucuuuuauuugggaagaaugacuuuagcagguaauggcuagaguuugacuguaccauuuugaauaagugacgacuaacuaugugccagcagucgcgguaauacauaggucgcaagcguuauccggauuuauugggcguaaagcaagcgcaggcggauugaaaagucugguguuaaaggcagcugcuuaacaguuguaugcauuggaaacuauuaaucuagagugugguagggaguuuuggaauuucauguggagcggugaaaugcguagauauaugaaggaacaccaguggcgaaggcgaaaacuuaggccauuacugacgcuuaggcuugaaaguguggggagcaaauaggauuagauacccuaguaguccacaccguaaacgauagauacuagcugucggggcgauccccucgguagugaaguuaacacauuaaguaucucgccuggguaguacauucgcaagaaugaaacucaaacggaauugacggggacccgcacaagugguggagcauguugcuuaauucgacgguacacgaaaaaccuuaccuagacuugacauccuuggcaaaguuauggaaacauaaugccgagugacagguggugcaugguugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuuaucguuaguuacauugucuagcgagacugcuaaugcaaauuggaggaaggaagggaugacgucaaaucaucaugccccuuaugucuagggcugcaaacgugcuacaauggccaauacaaacagucgccagcuuguaaaagugagcaaaucuguaaaguuggucucaguucggauugagggcugcaauucguccucaugaagucggaaucacuaguaaucgcgaaucagcuaugucgcggugaauacguucucgggucuuguacacaccgcccgucaaacuaugaaagcugguaauauuuaaaaacguguugcuaaccauuaggaagcgcaugucaaggauagcaccggugauuggaguuaagucguaacaagguaccccuacgagaacguggggguggauca .....<<<<..[.(((..>>>>.<<<<.<<<<<..<<<<<<<<.....<<<..<<..<<<..<<.<<<<<<....>>>>>>.>>>>>......<<........<<<.<<<..<<......<<<<<<.<<.....<<<<<<....>>>>>>......>>.>.....<<<<<<..........>>>>>>....<<<<<<....>>>>>>>>>>>.....>>>>>.>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>...>>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>.>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<.......<<<.....>>>......>>>>...<...<<<.......<<<<<<<<<........>>>>>>>>>........>>>....>.....<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<..<<<<<.<<<<.....<<<<<<<.....>>>>>>>..>>>>.>>>..>>.>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<<..<<<......>>>.....>>>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<......>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<......<<<<<....>>>>>....>>....))).].<<<<.<<<<<<<.<<.<<<<<...<<<<<<<<<<......<<........>>..........<<<<<<<........<<<.......<<<<<....>>>>>....>>>.....<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<...........>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>....>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>....>>>>>>>......<....<<<<<<<........>>>>>>>....>......>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>.....<..<<.<.<<<<.<<<..<<<<<<..<<<<.....<<<<<.<<<<..<<....>>.>>>>>>>>>....>>>>..>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .....((((..[.[[[..)))).((.(.((((.(.(.(((((.(....(.(..((..(((..((.((((.(....).)))).)))))......(((.......(((..((..(.......((((.(.((.....((((((....))))))......)).).....((((..(........)..))))....((((((....)))))).))))......)))..))).(((....(((..((((((((.......)))))))))))......)))..(((((.((....)).)...))))))).(((((............))))).((((....))))...)).).).).....(.(((...(((((....)))).)))))..).)))).)..((((......((((.....)))).....))))....(..(((...(....(((.((((........)))).)).)...)....)))...)......((((([[[...(((((.....((.]]])).......))))))))))..)))))).))..........((([[...(.((((...(((.((((((..((((..(.(.......((((((.....))))))....)..).))..)).))))))..((((.((((....(((((((....(((((.(...((........))......).)))))....).......((....)).))))))...))))..)))..))))...))))....(.((((...((...((((.........))))...)))))).)......{...((((((..(((..((((........))))..)))...((..]])).....)))))))))).(.(........((....))......).)....]]].](......((((.(.....(.(((..((((((.(((......((........))..........(.(((....(......(........(((((....))))).....)....).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((.........)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))......))).)...)).).)))))).(...(.(((((.....(((..(((.((((....))))).))....)))....))))).)......(....(((((((........)))))))....)..)..))).).....(((((((..........)))))))...........).))))......)..(.(..((.(.((((.(((..((((((...(.......(((((.((((..((....)).)))))))))......)...))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... 70S ribosome with EF-Tu-tRNA and P-site tRNA in Mycoplasma pneumoniae cells; 16S ribosomal RNA 7pak 6 76 5.3 RF00005 URS000054164D_272634 36171285,36171285 0030533 0006412 272634 ggucuuguagcucagucgguagagcaacggucugaagaaccgugugucggcaguucgauucugcccgagaccacca <<<<<<...<<<<........>>>><<<<<<.......>>>>>.>...<<<<<.......>>>>>.>>>>>>.... .(.((.(..(((((....[).))))(.((((.......))))..).....(((..]....)))..).))..).... 70S ribosome with EF-Tu-tRNA and P-site tRNA in Mycoplasma pneumoniae cells; tRNA-Phe 7pak 7 76 5.3 RF00005 URS000054164D_272634 36171285,36171285 0030533 0006412 272634 ggucuuguagcucagucgguagagcaacggucugaagaaccgugugucggcaguucgauucugcccgagaccacca <<<<<<...<<<<........>>>><<<<<<.......>>>>>.>...<<<<<.......>>>>>.>>>>>>.... .(.((.(..(((((....[).))))(.((((.......))))..).....(((..]....)))..).))..).... 70S ribosome with EF-Tu-tRNA and P-site tRNA in Mycoplasma pneumoniae cells; tRNA-Phe 7pal 3 2878 4.7 RF02540,RF02541 URS0000AB9B3C_272634 36171285 0003735 0005840 272634 aguuacuaagggcuuaugguggaugccuuggcacuaauaggcgaugaaggacguguuaaccugcgauaagcuucggguaggugguaagaaccucagauccggagauuuccgaauggagcaauccgguaguuggaaacagcuaucauuaauugaugaauaaauagucaauuaaagcaauacguggugaagugaaacaucucaguagccacaggaaaagaaaacgaaugugauuccguguguaguggcgagcgaaagcggaacaggccaaacuuaucauuagauagggguuguagggcuugcaauguggacuugaaaacgauagaagaagcuguuggaaagcagcgcgcaaaagggugauagccccguauuugaaauuguuuucauaccuagcgagaucccugaguagcucggaaaacguuauuuugagugaaucugcccagaccauuggguaagccuaaauacuaauuagugaccgauagcgaaacaguaccgugagggaaaggugaaaagaacccagagaugggagugaaauagauucugaaaccauaugccuacaacgugucagagcacauuaaugugugauggcgugcguuuugaaguaugagccggcgaguuaugauagcaagcguuaguuaaccaggagauggggagcuguagcgaaagcgaguuuuaaaagagcguuuguuuguuauuauagacccgaaacggguugagcuagucaugagcagguugaagguugaguaacaucaacuggaggaccgaaccgacucucguugaaacgauagcggaugacuugugauuaggggugaaauuccaaucgaaauccgugauagcugguucucgucgaaauagcuuuaaggcuagcgugagaucacaaauaaguggagguaaagcuacugaauguaugauggcgccggcguacugaauacaauuaaacucugaaugccauuuauuuuauucucgcagucagacagugggggauaagcuucauugucaagaggggaagagcccagaucauuaaauaagguccccaaaauauacuaaguggaaaaggaugugaaagugcuaaaacagcaaggauguuggcuuagaagcagccaucguuuaaagagugcguaacagcucacuugucgaguguuuuugcgccgaagauguaacggggcuaaguauauuaccgaauuuauggauaagauuuauaucuugugguagacgagcguuguauuggaguugaagucaaagcgugagcauugguggauccaauacaagugagaaugccggcaugaguaacgcuugggagugagaaucucccaaaccgauugacuaagguuuccuggaccagggucguccuuccaggguuagucuggaccuaagcugaggcugaaaagcguaggcgauggacaacagguuaauauuccuguacuuacaguuagacugauggagugacaaagaagguuuuccacccccauaauuggauuuggggauaaaucauaaggugguacaauaggcaaauccguugugcauaacauugagugaugaugucgagugaaaguagcgaaggugguauuaaucaugcuuucaagaaaagcuucuaggguuaaucuagcuguaaccaguaccgagaacgaacacacguagucaaggagaggauccuaagguuagcgagugaacuauagccaaggaacucugcaaauuaaccccguaaguuagcgagaaggggugcuuauguaaaaguaagccgcagugaagaacgaggggggacuguuuaacuaaaacacaacucuaugccaaaccguaaggugauguauauggggugacaccugcccagugcuggaagguuaaagaaggagguuagcgcaagcgaagcuuuuaacugaagccccagugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuagucggguaaauuccgucccgcuugaaugguguaaccaucucuugacugucucggcuauagacucggugaaauccagguacgggugaagacacccguuaggcgcaacgggacggaaagaccccgugaagcuuuacuguagcuuaauauugaucaggacauuaucauguagagaauagguaggagcaaucgaugcaaguucgcuaggacuuguugaugcgaaagguggaauacuacccuugguugugugcuguucuaauugguaacuguuauccaguuucaagacaguguuaggugggcaguuugacuggggcggucgccuccuaaaagguaacggaggcguacaaagguaccuucaguacgguuggaaaucguauguagaguguaaugguguaagggugcuugacugugagacauacaggucgaacaggugagaaaucaggucauagugauccggugguccaguauggaauggccaucgcucaacggauaaaagcuacuccggggauaacaggcugauacugcccaagaguucauaucgacggcaguguuuggcaccucgaugucgacucaucucauccucgagcugaagcagguucgaaggguucggcuguucgccgauuaaagagauacgugaguuggguucaaaccgucgugagacagguuggucccuaucuauugugcccguaggaagauugaagaguguugcuucuaguacgagaggaccgaagcgaggacaccucuuaugcuccaguuguagcgccagcugcaccgcuggguaguaacgugucuauuagauaaacgcugaaagcaucuaagugugaaacuaucucaaagauuaaucuucccauuucgcaagaaaguaagagccgucaaagacgaugacguugauagguuacagguguaagcauagugauauguugagcugaguaauacuaauugcucgaggacu <<<......<<<<.<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>....<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((....<<<<<......>>>>>......<<<<<<<<<.....<....<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>...>..>>>>>..>>>>.....<<<<<<<<.......>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<....>>>>.............}....>>>>>>.>>>>.......<<<<..<<<<......>>>>..>>>>...<<..........>>.<<<<<<....<<<<<<<<<<<<<...<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>...>.>>>...<<<.<<.<<........>>.>>>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<....<<<<<<<<<<......<<....<<..<<<<<...<<<<<<>>>>>.>...>>>>>..>>..>>.......>>>>>>>>>>...>>>>>>.>>..<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((...<<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>...........))).....>>>>>>>>>>...>>>>>>><<<<<<<....>>>>>>>....>>>>>><<<<<<<<<<<<......<<<<<.<<....>>.>>>>>...>>>>>>>>>>.>>.....>>>>>>.......<<...<<<<<<.......>>>>>><<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<.<...<<<<<...<<.<..<<<<..<<<<<<<<<....(((...>>>>><<..<<<<<..<<<<<<<<<<<.<<.....>>>>>>>>>....>>>>..>>>>>...>><..<<.......>>...>>>>>....>>>>....>>>........>>>>.>.>......>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>...>>>..<<<<<...<<<<<<<<.<<...............<<<<<....<....>.....>>>>><<<<<<......>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<..<<..<<<<<<<.<<....>>..>>>>>>>..>>..>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<.<<<<.....>>>>.>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>>>>>>>>...........<<<<<........>>>>>..<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<<.<<.<<<.<<<<.<<<<...........<<<<<..<<<......<<<<<.<<.....>>>>>>>...>>>.............>>>>>..>>>>.>>>>.>>>.>>...<<<..<<<<<.....>>>>>.>>>....>>>>>>>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<<....<<<..<<<<<<<...............>>>>>>><<<<<<...<<<<...<<<<<<<<<<<.)))>>>>>>..>>>>>...>>>>.>>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>........>>>>>>>..................<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> ((........(((.(((((.....(((..(((((((((((((......((((((....[[[.))).....((((((...(((]]]....)))......))))))...)))....(((....)))((((((((....)))))))).(((((((((.........))))))))).))....((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...(((((......)))))......(((((((((......(...((((((((((.(((...(((((......)))))[[......(((.....]])))...)))...))))))))))...)..)))))..)))))....(((((((((.[..).))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((....))))............)).....))))).)))......(.((((..(((...[....)))..))))...((..........)).(((.((....(((((((((((((....(....(((.....)))....)....((....))..((((.....))))....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)<)))...(((.((.((........)).)))))..).))))))))).(.((.......))...)..))))))......).))..((((((....(((((....)))))((((((((....((((((..((.....(((........((.((....(((....))).....)).))......)).).....))..))))))...)))))).))..((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(((((((.....(.....((..(.(((....(.....{..((((.(.(..(((.........)))..).).....(...((......)).).))))....)....))).).))...........]]].)...))))))))))...)))))).).(((((....)))))......))))))(.(((((..(((......(.(((.((....))]))).)...)))..)))))..).....).)))).......((...((((((.......))))))(((.....(..(..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((.(...(((.....((((..((.(..(((((((((.....{{...)))))((..(((((..((((((((((..((.....)).))))))....))))..)))))...))...((.......))....))))....).))...))))(..)......)))...).....))))))))))))))).))).....((......))..).).((((.....))))...)))..((((....((((((((.((..(............(((((....(.[..).....)))))((((((......))))))(...).......((((.((((.>.((.........))...(((((((.....(((....))).......))))))).]((((.(((..(((((((..(((...((...((((...((....))....))))...))...))))))))..)))))(((((.........)))))........((..........(.(((.......))).)..)..)....))))...)).)).))))....))).)))))))).))))))......).[..(((((......].)))))..(((.(((..(((.((......((((.((((((..(((((.((((((((..((.(((.((((.(.((.([.....{..(((.(..(((......(((((..(...].).)))))...)))...........}.).)))).)).).)))).))).))...(((..(((((.....))))).))).....))))))))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).(.]..[[[.)....)))))))...((((..(((...{..)))..)))).(((....))).))]]].......(((((((.((..]]]]..))))))))).....)}......))))..)))))).......((((.(.((((((...((.......))...))))))...)))).)........(.((.((((((..((.((((((......))))))...)).(((((.....))))).....)))))..)...))..).....(((((((....))).))))....))..))).))).)))[...(((((((....(((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))..)))))...)))).)))))....((....((((.....}.......))))....))..)))...]....)))))))(...(........)....(((((((((.......)))))....((((((((.((.....(((((....)))))....))..))))).)))...))))...).)) 70S ribosome with A- and P-site tRNAs in Mycoplasma pneumoniae cells; 23S ribosomal RNA 7pal 4 105 4.7 RF00001 URS000000E851_272634 36171285 0003735 0005840 272634 uuuggugcccaugucgcuguggaaacaccugguuccauuucgaacccagcaguuaagcacaguggagccgaauguagcugcagugagaauaggaaagcaccaagc <<<<<<<<.....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<.......<<<..>>>.......>>...>>>>>>>>. .(((((((.....((((((((.....((((((...(.....)...))))..))....)))))).)).((......................))...))))))).. 70S ribosome with A- and P-site tRNAs in Mycoplasma pneumoniae cells; 5S ribosomal RNA 7pal 5 1493 4.7 RF00177,RF01959,RF01960 URS00019B76CF_272634 36171285 0003735 0005840 272634 ucugagaguuugauccuggcucaggauuaacgcuggcggcaugccuaauacaugcaagucgaucgaaaguaguaauacuuuagaggcgaacgggugaguaacacguauccaaucuaccuuauaaugggggauaacuaguugaaagacuagcuaauaccgcauaagaacuuugguucgaaucaaaguugaaaggaccugcaaggguucguuauuugaugagggugcgccauaucagcuaguuggugggguaacggccuaccaaggcaaugacguguagcuaugcugagaaguagaauagccacaaugggacugagacacggcccauacuccuacgggaggcagcaguagggaauuuuucacaaugagcgaaagcuugauggagcaaugccgcgugaacgaugaaggucuuuaagauuguaaaguucuuuuauuugggaagaaugacuuuagcagguaauggcuagaguuugacuguaccauuuugaauaagugacgacuaacuaugugccagcagucgcgguaauacauaggucgcaagcguuauccggauuuauugggcguaaagcaagcgcaggcggauugaaaagucugguguuaaaggcagcugcuuaacaguuguaugcauuggaaacuauuaaucuagagugugguagggaguuuuggaauuucauguggagcggugaaaugcguagauauaugaaggaacaccaguggcgaaggcgaaaacuuaggccauuacugacgcuuaggcuugaaaguguggggagcaaauaggauuagauacccuaguaguccacaccguaaacgauagauacuagcugucggggcgauccccucgguagugaaguuaacacauuaaguaucucgccuggguaguacauucgcaagaaugaaacucaaacggaauugacggggacccgcacaagugguggagcauguugcuuaauucgacgguacacgaaaaaccuuaccuagacuugacauccuuggcaaaguuauggaaacauaaugccgagugacagguggugcaugguugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuuaucguuaguuacauugucuagcgagacugcuaaugcaaauuggaggaaggaagggaugacgucaaaucaucaugccccuuaugucuagggcugcaaacgugcuacaauggccaauacaaacagucgccagcuuguaaaagugagcaaaucuguaaaguuggucucaguucggauugagggcugcaauucguccucaugaagucggaaucacuaguaaucgcgaaucagcuaugucgcggugaauacguucucgggucuuguacacaccgcccgucaaacuaugaaagcugguaauauuuaaaaacguguugcuaaccauuaggaagcgcaugucaaggauagcaccggugauuggaguuaagucguaacaagguaccccuacgagaacguggggguggauca .....<<<<..[.(((..>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<<<<<....>>>>>>.>>>>>......<<........<<<<<<...<<...<..<<<<<<.<<.....<<<<<<....>>>>>>......>>.>.....<<<<<<<<<<..>>>>>>>>>>....<<<<<<....>>>>>>>>>>>..>..>>.>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>...>>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>......<..<<<....<<<<....>>>>..>>>.>>>.>>>>>>..<<<<......<<<<.....>>>>.....>>>>...<...<<<.......<.<<<<<<<........>>>>>>>.>........>>>....>.....<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<..<<<<<<<<<<.....<<<<<<<.....>>>>>>>..>>>>>>>..>>>.>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<<..<<<......>>>.....>>>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<......>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<.....<<<<<....>>>>>...>>>....))).].<<<<.<<<<<<<.<<.<<<<<<.<<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<......<<<<<<....>>>>>>...>>>.>>.<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<.........>>>>>>>.....<<<<<....>>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.>...<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>.....<..<<.<.<<<<.<<<..<<<<<<..<<<<<....<<<<<.<<<<..<<....>>.>>>>>>>>>...>>>>>..>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .....((((..[.[[[..)))).((((.(((....(((((((((......(.(((..(((..((.(((((......))))).)))))......(((.......((((.((..((...(....((.(.((.....((((((....))))))......)).).....(((((((........)))))))....(.(((......))).).))....)..))).))))).(((....((...((((((((.......)))))))).))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...))))...).....(..((....((((....))))..)).).)).))))))..(.((......((((.....)))).....).))....(..(((...(...((((.(((..........))).))))...)....)))...)......((((([[[...(((((.....((.]]])).......))))))))))....)))))))..........((([[...(.((((...(((.((((((..((.(((((((.....(((((((.....)))))))..)))))))...)).))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((..(((((......)))))..)))...((..]])).....)))))))))).(((.......(((....))).....)))....]]].](.(((.(((((((.((..(((((..(((((((((.......((........))..........(((((((..(...((..(.......((..(....)..)).....)..))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((.........)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))....).)))))))).(...(.((((......(((..(((.((((....))))).))....))).....)))).)......(....(((((.(........).)))))....)..)..))))).....(((((((..........)))))))......))...))))))))))..)..(.(..((.(.((((.(((..((((((..(((((....(((((..(((..((....)).))).)))))...)))))..))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... 70S ribosome with A- and P-site tRNAs in Mycoplasma pneumoniae cells; 16S ribosomal RNA 7pal 6 76 4.7 RF00005 URS000054164D_272634 36171285 0030533 0006412 272634 ggucuuguagcucagucgguagagcaacggucugaagaaccgugugucggcaguucgauucugcccgagaccacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... .((((.(..((((........)))).(((((.......))))).....(((((.......)))))).))).).... 70S ribosome with A- and P-site tRNAs in Mycoplasma pneumoniae cells; tRNA-Phe 7pal 7 76 4.7 RF00005 URS000054164D_272634 36171285 0030533 0006412 272634 ggucuuguagcucagucgguagagcaacggucugaagaaccgugugucggcaguucgauucugcccgagaccacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... .((((.(..((((........)))).(((((.......))))).....(((((.......)))))).))).).... 70S ribosome with A- and P-site tRNAs in Mycoplasma pneumoniae cells; tRNA-Phe 7pam 3 2878 6.8 RF02540,RF02541 URS0000AB9B3C_272634 36171285 0003735 0005840 272634 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<........<<<<.<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<<<<.........>>>>>>>>.>>>....<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...(((....<<<<<......>>>>>......<<<<<<<<<......<...<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>...>..>>>>>..>>>>.....<<<<<<<<.......>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<....>>>>.............}....>>>>>>.>>>>.......<<<<..<<<<......>>>>..>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<...<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<.<<........>>.>>>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<....<<<<<<<<<<.......<....<<<.<<<<<...<.<<<<>>>>..>...>>>>>.>>>..>........>>>>>>>>>>...>>>>>>.>>..<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((...<<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>...........))).....>>>>>>>>>>...>>>>>>><<<<<<<....>>>>>>>....>>>>>><<<<<<<<<<<<......<<<<<.<<....>>.>>>>>...>>>>>>>>>>.>>.....>>>>>>.......<<...<<<<<<.......>>>>>><<<<....<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<.<...<<<<<...<<<<...<<<..<<<<<<<<<....(((...>>>>><<..<<<<<..<<<<<<<<<<<.<<.....>>>>>>>>>....>>>>..>>>>>...>><..<<.......>>...>>>>>....>>>....>>>>........>>>>.>.>......>>>>>>>>>>>>>>>..>>.....<<......>>.>>>>.<<<<.....>>>>..>>>>..<<<<<...<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<......>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<..<<<<<<<.<<....>>..>>>>>>>..>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<.<<<<.....>>>>.>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>>>>>>>>...........<<<<<........>>>>>..<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<<.<<.<<<.<<<..<<<<...........<<<<<..<<.......<<<<<<<......>>>>>>>....>>.............>>>>>..>>>>..>>>.>>>.>>...<<<..<<<<<.....>>>>>.>>>....>>>>>>>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>......<.[.(((>.....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>......<<<<<..<<<<<<<...<<.......>>...>>>>>>>...>>>..>>.......<<<..<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>......>>>.......<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<<....<<<..<<<<<<<...............>>>>>>><<<<<<...<<<<...<<<<<<<<<<<.)))>>>>>>..>>>>>...>>>>.>>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>........>>>>>>>..................<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>......> 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70S ribosome with A*- and P/E-site tRNAs in Mycoplasma pneumoniae cells; 23S ribosomal RNA 7pam 4 105 6.8 RF00001 URS000000E851_272634 36171285 0003735 0005840 272634 uuuggugcccaugucgcuguggaaacaccugguuccauuucgaacccagcaguuaagcacaguggagccgaauguagcugcagugagaauaggaaagcaccaagc <<<<<<<<.....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<..<....<<<..>>>.....>.>>...>>>>>>>>. .(((((((.....((((((((.....((((((...(.....)...))))..))....)))))).)).((.......(......).......))...))))))).. 70S ribosome with A*- and P/E-site tRNAs in Mycoplasma pneumoniae cells; 5S ribosomal RNA 7pam 5 1493 6.8 RF00177,RF01959,RF01960 URS00019B76CF_272634 36171285 0003735 0005840 272634 ucugagaguuugauccuggcucaggauuaacgcuggcggcaugccuaauacaugcaagucgaucgaaaguaguaauacuuuagaggcgaacgggugaguaacacguauccaaucuaccuuauaaugggggauaacuaguugaaagacuagcuaauaccgcauaagaacuuugguucgaaucaaaguugaaaggaccugcaaggguucguuauuugaugagggugcgccauaucagcuaguuggugggguaacggccuaccaaggcaaugacguguagcuaugcugagaaguagaauagccacaaugggacugagacacggcccauacuccuacgggaggcagcaguagggaauuuuucacaaugagcgaaagcuugauggagcaaugccgcgugaacgaugaaggucuuuaagauuguaaaguucuuuuauuugggaagaaugacuuuagcagguaauggcuagaguuugacuguaccauuuugaauaagugacgacuaacuaugugccagcagucgcgguaauacauaggucgcaagcguuauccggauuuauugggcguaaagcaagcgcaggcggauugaaaagucugguguuaaaggcagcugcuuaacaguuguaugcauuggaaacuauuaaucuagagugugguagggaguuuuggaauuucauguggagcggugaaaugcguagauauaugaaggaacaccaguggcgaaggcgaaaacuuaggccauuacugacgcuuaggcuugaaaguguggggagcaaauaggauuagauacccuaguaguccacaccguaaacgauagauacuagcugucggggcgauccccucgguagugaaguuaacacauuaaguaucucgccuggguaguacauucgcaagaaugaaacucaaacggaauugacggggacccgcacaagugguggagcauguugcuuaauucgacgguacacgaaaaaccuuaccuagacuugacauccuuggcaaaguuauggaaacauaaugccgagugacagguggugcaugguugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuuaucguuaguuacauugucuagcgagacugcuaaugcaaauuggaggaaggaagggaugacgucaaaucaucaugccccuuaugucuagggcugcaaacgugcuacaauggccaauacaaacagucgccagcuuguaaaagugagcaaaucuguaaaguuggucucaguucggauugagggcugcaauucguccucaugaagucggaaucacuaguaaucgcgaaucagcuaugucgcggugaauacguucucgggucuuguacacaccgcccgucaaacuaugaaagcugguaauauuuaaaaacguguugcuaaccauuaggaagcgcaugucaaggauagcaccggugauuggaguuaagucguaacaagguaccccuacgagaacguggggguggauca .....<<<<..[.(((..>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<....>>>>>>.>>>>>......<<........<<<.<<<..<<...<...<<<<<.<<.....<<<<<<....>>>>>>......>>.>.....<<<<<<<<.<.>..>>>>>>>>....<<<<<<....>>>>>>>>>>...>..>>>>>.>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>...>>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<.....>>>>.....>>>>...<...<<<.......<<<<<<<<<........>>>>>>>>>........>>>....>.....<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<..<<<<<<<<<<.....<<<<<<<.....>>>>>>>..>>>>>>>..>>>.>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<<..<<<......>>>.....>>>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<......>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<.....<<<<<....>>>>>...>>>....))).]<<<<<.<<<<<<<.<<..<<<<...<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<.....<<<<<<....>>>>>>..>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<.........>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>....>>>>>>>......<....<<<<<<<........>>>>>>>....>......>>>>.....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<..<<<<<....<<<<<<.<<<..<<....>>.>>>>>>>>>...>>>>>..>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .....(((...[.[[[...))).((((.(((((...(((.((((....(...(((..(((..((.((((((....)))))).)))))......(((.......((((.((..((...(...(((((.((.....((((((....))))))......)).).....(((((((..(())..)))))))....((((((....))))))))))...)..)))).)))).((.....(((..(((((.((.......)).)))))))).......))..((((((((....))))...))))))).(((((............))))).((((....))))...)))..).).....(..((...(((((....)))).))).).)).).)))...((((......((((.....)))).....))))....(..(((...(.....((.((((........)))).)).....)....)))...)......(.((([[[...(((((.....((.]]])).......)))))))).)..)))))))))..........((([[...(.((((...(((.((((.(..(((((.(((.......((((((.....))))))....))).)).).)).).))))..((((.((((....(((((((....(((((.(...((........))......).)))))....).......((....)).))))))...))))..)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((.(.......)))))))))...((..]])).....)))))))))).(((.......(((....))).....)))....]]].](((((.(((((((..(..(((((..((((((((..(.....((........))..........((((((...(...(((((((.....((..(....)..))..))))).))).((.((....((.(((.(....((((((.((....))....(((......)))...)))))).....((.(.(((.(((.........))).)))..(..(((((....))))).....)..).)).....).).))....))..)))).....))))))...)..)))))))).(...(.((((......(((..(((.((((....))))).))....))).....)))).)......(....(((((.(........).)))))....)..)..))))).....(.(((((..........))))).)......)....)))))))))).))..(.(..((.(.((((.(.(..((.(((..((((.....((.((..(((..((....)).))).)).))....))))..))).))..).).))))..).))...)..)..(((((((((....)))))))))}..... 70S ribosome with A*- and P/E-site tRNAs in Mycoplasma pneumoniae cells; 16S ribosomal RNA 7pam 6 76 6.8 RF00005 URS000054164D_272634 36171285 0030533 0006412 272634 ggucuuguagcucagucgguagagcaacggucugaagaaccgugugucggcaguucgauucugcccgagaccacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (.(((((..((((........))))..((((.......))))......(((((.......)))))))))).).... 70S ribosome with A*- and P/E-site tRNAs in Mycoplasma pneumoniae cells; tRNA-Phe 7pam 8 76 6.8 RF00005 URS000054164D_272634 36171285 0030533 0006412 272634 ggucuuguagcucagucgguagagcaacggucugaagaaccgugugucggcaguucgauucugcccgagaccacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (.(((((..((((........))))..((((.......))))......(((((.......)))))))))).).... 70S ribosome with A*- and P/E-site tRNAs in Mycoplasma pneumoniae cells; tRNA-Phe 7pan 3 2878 9.7 RF02540,RF02541 URS0000AB9B3C_272634 36171285 0003735 0005840 272634 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<<.......<<<<.<<<<<<.....[[.(((<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<<<<.........>>>>>>>>.>>>....<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((.....<<<<<....>>>>>.......<<<<<<<<<.....<....<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>...>..>>>>>..>>>>.....<<<<<<<<.......>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.)))..............<<....>>....]].........<<<<....>>>>..................>>>>>>.>>>>.......<<<<..<<<<......>>>>..>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<....<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>...>.>>>...<<<.<<.<<........>>.>>>>>....>>>>>>>>>...<<.......>>......>>>>>>>.....>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<....<<<<<<<<<<......<<....<<..<<<<<...<...........>...>>>>>..>>..>>.......>>>>>>>>>>...>>>>>>..>..<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((...<<<<<<<...........<<..<<<<<<<..........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>......>>>>>>>.>>...........))).....>>>>>>>>>>...>>>>>>><<<<<<<....>>>>>>>....>>>>>><<<<<<<<<<<<......<<<<<.<<....>>.>>>>>...>>>>>>>>>>.>>.....>>>>>>.......<<...<<<<<<.......>>>>>><<<<....<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<<...<<<<...<<<..<<<<<<<<<....(((...>>>>><<..<<<<<..<<<<<<<<<<..<<.....>>.>>>>>>....>>>>..>>>>>...>>...<<.......>>....>>>>....>>>....>>>>........>>>>>..>>.....>>>>>>>>>>>>>>>..>>.....<<......>>.>>>>.<<<<.....>>>>..>>>>..<<<<<...<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<......>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<..<<.<<<..<<....>>..>.>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<.............<<<<.....>>>>.......>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>>>>>>>>...........<<<<<........>>>>>..<<<<<<<..(((.((......<<<<.((<<<<..<<<<..<<<<<<<<..<<.<<<.<<<<.<<<<...........<<<<<..<<.......<<<<<<<......>>>>>>>....>>.............>>>>>..>>>>.>>>>.>>>.>>...<<<..<<<<<.....>>>>>.>>>.....>>>>>>>>...>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.........[.((......>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))].......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..))>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<.<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>..>....<<<<<<<....>>>.>>>>....))..))).>>>>>>>....<<<<<<<....<<<..<<<<<<<.....<....>....>>>>>>><<<<<<...<<<<...<<<<<<<<<<<.)))>>>>>>..>>>>>...>>>>.>>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>........>>>>>>>..................<<<<<<<<.........>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>.....>> (........((((.(((((.....(((..(((((((((((((......(((((......[[..)).....((.(((...(((]].....)))......))).))...)))....(((....)))(((((.((....)).)))))..((((((((.........))))))))..))....((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.(.(((((......)))))..)...((((((.((..........(((((((.((..((...(((((......)))))[[......(((.....]])))...))....)).)))))))......)).))..))))).....(((..(((.[..).))..))).......(((((].[[[[)))))..)))......)).))))))).))...............((....))....)).........((((....)))).............).....))))).)))).....(.(.((..((((..[...))))..)).).<.(.(........).).((((((....(((.(((.(((((....(....(((.....)))....)....((....))..(.((.....)).)....))))).))).)))..((.(...((((((.....((((((.(((.((((....(((((......)))))....).)))...(((.((.((........)).)))))..).)).)))))).(.((.......))...)..))))))......).))..((((((....((((......))))...(((((....((((((((((.....(((....(((.((((....(....().....)....)))).)))..)).).....))))))))))...)))))......(((((((..(......)..)))))))....(((......)))....((..(((...((([[[...(((((((.....(.....((..(..((((..(.....{.(((((.(.(..(((.........)))..).).....(...((......)).).)))))...)..))))..).))...........]]].)...))))))))))...))).)).(.(((((....))))).)....))))))(((((((..(((.......((((.((....))]))))....)))..))))).)).....)))))).......((...((((((.......)))))).(.(....((((..((..(((((((...((.....)).))))))....[[.(((.((..((((...(((....)))...)))..)))...(((((........)))))]](((((((((((((...(((((...((((..(.....(((((((((.....{{...)))))(...(((((..(.(((.((((..((.....)).)))).)....)).)..)))))....)(..((.......))...))))).......)...))))(..)....)))))..)).....))))))))))))))..))).....((......)).)))).((((.....))))..)..)..((((....((((((((.((..(............(((((......[........)))))((((((......))))))(...).......((((.(.((...((.........))...((((.((.....(((....))).......)).)))).]((((.(((..(((((((..((....((....((((..((....))...))))....))....)))))))..)))))(((((.........))))).........(..........(.(((.......))).)..).......))))...))..).))))....))).)))))))).))))))......).[..(((((.....>].)))))..(((((((..(((.((......((((.((((((..(((((.((.(((((..((.(((.((((.(.((.(......[..(((((..(((.......((((.(.......)))))....)))...........].)))))).)).).)))).))).))...(((..(((((.....))))).))).....))))).))..)))).).(((......[)))((((((..........]))))))(.((...((.((((.(..((((.........))))....).......[[......)))).))...((((..(((...{..)))..)))).(((....))).))]]........(((((((.((..]]]]..))))))))).....)}......))))..)))))).......(((..(.((((((...((.......))...))))))...).)).)........((((.((((((..((((((.((......)).)))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....))..))).)))))))[...(((((((....(((..(.(((((.....(....)....))))).).(((.....((((...((((.((.(((.}}.))).))...))))...))))...)))....((....((.(.....}.......).))....))..)))...]....)))))))(.(.(.......).....(((((((((.......)))))....(((.((((.(((....(((((....)))))...)))..))))..)))...)))).).)..) 70S ribosome with A/P- and P/E-site tRNAs in Mycoplasma pneumoniae cells; 23S ribosomal RNA 7pan 4 105 9.7 RF00001 URS000000E851_272634 36171285 0003735 0005840 272634 uuuggugcccaugucgcuguggaaacaccugguuccauuucgaacccagcaguuaagcacaguggagccgaauguagcugcagugagaauaggaaagcaccaagc .<<<<<<<.....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<..<<...<<....>>....>>.>>...>>>>>>>.. .(.((........((((((((.....((((((...(.....)...))))..))....)))))).))..(...(...(......)....)...)......))..). 70S ribosome with A/P- and P/E-site tRNAs in Mycoplasma pneumoniae cells; 5S ribosomal RNA 7pan 5 1493 9.7 RF00177,RF01959,RF01960 URS00019B76CF_272634 36171285 0003735 0005840 272634 ucugagaguuugauccuggcucaggauuaacgcuggcggcaugccuaauacaugcaagucgaucgaaaguaguaauacuuuagaggcgaacgggugaguaacacguauccaaucuaccuuauaaugggggauaacuaguugaaagacuagcuaauaccgcauaagaacuuugguucgaaucaaaguugaaaggaccugcaaggguucguuauuugaugagggugcgccauaucagcuaguuggugggguaacggccuaccaaggcaaugacguguagcuaugcugagaaguagaauagccacaaugggacugagacacggcccauacuccuacgggaggcagcaguagggaauuuuucacaaugagcgaaagcuugauggagcaaugccgcgugaacgaugaaggucuuuaagauuguaaaguucuuuuauuugggaagaaugacuuuagcagguaauggcuagaguuugacuguaccauuuugaauaagugacgacuaacuaugugccagcagucgcgguaauacauaggucgcaagcguuauccggauuuauugggcguaaagcaagcgcaggcggauugaaaagucugguguuaaaggcagcugcuuaacaguuguaugcauuggaaacuauuaaucuagagugugguagggaguuuuggaauuucauguggagcggugaaaugcguagauauaugaaggaacaccaguggcgaaggcgaaaacuuaggccauuacugacgcuuaggcuugaaaguguggggagcaaauaggauuagauacccuaguaguccacaccguaaacgauagauacuagcugucggggcgauccccucgguagugaaguuaacacauuaaguaucucgccuggguaguacauucgcaagaaugaaacucaaacggaauugacggggacccgcacaagugguggagcauguugcuuaauucgacgguacacgaaaaaccuuaccuagacuugacauccuuggcaaaguuauggaaacauaaugccgagugacagguggugcaugguugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuuaucguuaguuacauugucuagcgagacugcuaaugcaaauuggaggaaggaagggaugacgucaaaucaucaugccccuuaugucuagggcugcaaacgugcuacaauggccaauacaaacagucgccagcuuguaaaagugagcaaaucuguaaaguuggucucaguucggauugagggcugcaauucguccucaugaagucggaaucacuaguaaucgcgaaucagcuaugucgcggugaauacguucucgggucuuguacacaccgcccgucaaacuaugaaagcugguaauauuuaaaaacguguugcuaaccauuaggaagcgcaugucaaggauagcaccggugauuggaguuaagucguaacaagguaccccuacgagaacguggggguggauca .....<<<<..[.((([.>>>>.<<<<.<<<<<..<<<<<<<<.....<<..<<<..<<<..<<.<<<<<<....>>>>>>.>>>>>......<<........<<<<<<...<<...<..<<<<<<.<<.....<<<<<<....>>>>>>......>>.>.....<<<<<<<<.<.>..>>>>>>>>.....<<<<<....>>>>>.>>>>>..>..>>.>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>...>>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>.>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<.......<<<.....>>>......>>>>...<<..<<<.......<<<<<<<<<........>>>>>>>>>........>>>...>>.....<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<..<<<<<<<<<<.....<<<<<<<.....>>>>>>>..>>>>>>>>..>>.>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<<..<<<......>>>.....>>>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<......>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<.....<<<<<....>>>>>...>>>..].))).]<<<<<.<<<<<<<.<<.<<<<<..<<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<.......<<<<<<....>>>>>>....>>.>>.<<<.<<<..<<<<<<.<.....<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<.........>>>>>>>.....<<<<<....>>>>>........>>>>.....>...>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.>...<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>....>>>>>>>......<...<.<<<<<<........>>>>>>>....>......>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<..<<<<<....<<<<<.<<<<..<<....>>.>>>>>>>>>...>>>>>..>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .....(((...[.[[[...))).((...((.((..(((((((((....(((.(((..(.(..((.((((((....)))))).))).)......(((.......((.((((..((...(..((((((.((.....((((((....))))))......)).).....((((.((........)).))))....((((((....)))))))))))..)..)))))).)).((.....(((..(((((.((.......)).)))))))).......))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(.(((....)))..))))).)).))))))..((((........((.....)).......))))....(..(((...(.....((.((((........)))).)).....)....)))...)......((((([[[...(((((.....((.]]])).......))))))))))..)).))..))..........((([[...(.((((....((.((.(((..((((((((((.....(((.(((.....))).)))..))))))))..)).)).)))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))))).)))..)))....))))....((((((....(...((((.........))))...).))))))......{...((((((..(((.(((.((......)).))).)))...((..]])).....)))))))))).(.(.......(((....))).....).)....]]].](((((.(((((((.....(.((...((((((((((......((........))..........(((((((..(...((.(((.......(.((....))..)...)))..))).((.((....((((((.(....((((((.((....))....(((......)))...)))))).....((((.(((((((.........)))))))..(..(.(.(....).).).....)..)))).....).).)))...))..))))....)))))))...)).)))))))).(...(.((((......(((..(((..(((....))).).))....))).....)))).)......(....(((((.(........).)))))....)..)...)).).....(((((((..........)))))))...........)))))))))).))..(.(..((.(.((((.(((...(((((...((.(....(((((..(((..((....)).))).)))))...).))...)))))...))).))))..).))...)..)..(((((((((....)))))))))}..... 70S ribosome with A/P- and P/E-site tRNAs in Mycoplasma pneumoniae cells; 16S ribosomal RNA 7pan 7 76 9.7 RF00005 URS000054164D_272634 36171285 0030533 0006412 272634 ggucuuguagcucagucgguagagcaacggucugaagaaccgugugucggcaguucgauucugcccgagaccacca <<<<<<<..<<<<........>>>>..<<<<.......>>>>......<<<<<.......>>>>>>>>>>>>.... (((((((..((.(........).))..((((.......))))......(((((.......)))))))))))).... 70S ribosome with A/P- and P/E-site tRNAs in Mycoplasma pneumoniae cells; tRNA-Phe 7pan 8 76 9.7 RF00005 URS000054164D_272634 36171285 0030533 0006412 272634 ggucuuguagcucagucgguagagcaacggucugaagaaccgugugucggcaguucgauucugcccgagaccacca <<<<<<<..<<<<........>>>>..<<<<.......>>>>......<<<<<.......>>>>>>>>>>>>.... (((((((..((.(........).))..((((.......))))......(((((.......)))))))))))).... 70S ribosome with A/P- and P/E-site tRNAs in Mycoplasma pneumoniae cells; tRNA-Phe 7pao 3 2878 7.0 RF02540,RF02541 URS0000AB9B3C_272634 36171285 0003735 0005840 272634 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<<<......<<<<.<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>....<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((....<<<<<......>>>>>......<<<<<<<<<...<.<....<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>...>>.>>>>>..>>>>.....<<<<<<<<.......>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<....>>>>.............}....>>>>>>.>>>>.......<<<<..<<<<......>>>>..>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<...<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>...>.>>>...<<<.<<.<<........>>.>>>>>....>>>>>>>>>...<<.......>>......>>>>>>>.....>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<....<<<<<<<<<<.....<.<....<<<.<<<<<...<<<<<..>>>>.>...>>>>>.>>>..>..>.....>>>>>>>>>>...>>>>>>.>>..<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((...<<<<<<<...........<<..<<<<<<<<.........<<<<<.<<...<<<.........>>>...>>.........<<......>>...>>>>>.....>>>>>>>>.>>...........))).....>>>>>>>>>>...>>>>>>><<<<<<<....>>>>>>>....>>>>>><.<<<<<<<<<<......<<<<<.<<....>>.>>>>>...>>>>>>>>>>..>.....>>>>>>.......<<...<<<<<<.......>>>>>>.<<<....<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<.<...<<<<<....<<<..<<<<..<<<<<<<<<....(((...>>>>><<..<<<<<..<<<<<<<<<<<.<<.....>>>>>>>>>....>>>>..>>>>>...>><..<<.......>>...>>>>>....>>>>...>>.>........>>>>>..>......>>>>>>>>>>>>>>>..>>.....<<......>>.>>>>.<<<<.....>>>>..>>>...<<<<<...<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<......>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<..<<...<<<<<<.<<....>>..>>>>>>...>>..>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<.<<<.......>>>.>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>>>>>>>>...........<<<<<........>>>>>..<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<<.<<.<<<.<<<<..<<<...........<<<<<..<<<......<<<<<<<......>>>>>>>...>>>.............>>>>>..>>>..>>>>.>>>.>>...<<<..<<<<<.....>>>>>.>>>....>>>>>>>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>......<...(((>.....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<.<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>..>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<<....<<<..<<<<<<<...............>>>>>>><<<<<<...<<<<...<<<<<<<<<<<.)))>>>>>>..>>>>>...>>>>.>>>>>><.<<<....<<<<<...........>>>>>....>>>>>>>........>>>>>>>..................<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> ((.(......(((.(((((.....(((..(((((((((((((......((((((....[[[.))).....((.(((...(((]]]....)))......))).))...)))....(((....)))(((((.((....)).)))))..((((((((.........))))))))..))....(((((......(...[..).......)))).).........((....))...(((((.....((.]...))....)))))...((((...(((((......)))))......(((((((((.....((...((((((((((..((...((((........))))[[......(((.....]])))...))....))))))))))..))..)))))..)))))....(((((.(((.[..).)).))))).......((((].[[[[))))...)))......)).))))))).))...............((....))....)).........((((....))))..(......)...).....))))).)))......(.(.((..((((..[...))))..)).)...(((........))).((((((....(((((((.(((.(....(....(((.....)))....)....((....))..(.((.....)).)....).))).)))))))..((.(...((((((.....((((((.(((.((((...((((((......))))))...).)))...(((.((.((........)).)))))..).)).)))))).(.((.......))...)..))))))......).))..(((..(....(((((....))))).(((((((....((((((.(((.....(.(....(((.(((((...(..(....)...)...))))).)))...).).....))).))))))...)))))).)...(((((((..(......)..)))))))....(((......)))....(((.(((...((([[[...(((((((.....(.....((..(..(((...(.......(((((.(((..(((.........)))..))).....(...((......)).).)))))...)...)))..).))...........]]].)...))))))))))...)))))).(((((((....)))))))....)..)))(.(((((..(((.......((((.((....))]))))....)))..)))))..).....))))))........(...((((((.......))))))(.......(.(...((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((((((((((...(.(((...((((..((((...((((((((.....{{...)))))(...(((((...(((((((((..((.....)).))))))....)))...)))))....)(..(.........)...)))).....))))...))))(..)....))).)..)).....))))))))))))))).))).....((......))..).).((((.....)))).....)..((((....((((((((.((..(....(.......(((((....(.[..).....)))))(((((........)))))(...).......(.((((.((...((.........))...((((.((.....(((....))).......)).)))).]((((.(((..((.((((..((....((...((.(...((....))....).))...))....))))))...)))))(((((.........)))))........((..........(.(((.......))).)..)..)....))))...))..)))).).)..))).)))))))).))))).......).[..(((((......].)))))..(((((((..(((.((......((((.((((((..(((((.((((((((..((.(((.(((...(((.(......[..(((((..(((.......(((((((....)))))))....)))...........].)))))).)))...))).))).))...(((..(((((.....))))).))).....))))))))..)))))..(((......[)))((((((..........]))))))([((...((.((((.(.(((((.........)))))...)...][.[[[......)))).))...((((..(((...{..)))..)))).(((....))).))]]].].....((((((..((..]]]]..)).)))))).....)}......))))..))))))......(((((.(.((((.((..((.......))...))))))...)))).).)......((((.((((((..((((((.(........).)))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....))..))).)))))))[...(((((((....(((..(((((((.....(....)....)))))))((((((...((((...(((((((((((.}}.))))))..)))))...)))).))))))..(((....((.(.............).))....))).)))...]....)))))))(...(.......).....(((((((((.......)))))....((((((((.((.....(((((....)))))....))..))))).)))...))))...)))) 70S ribosome with EF-G, A*- and P/E-site tRNAs in Mycoplasma pneumoniae cells; 23S ribosomal RNA 7pao 4 105 7.0 RF00001 URS000000E851_272634 36171285 0003735 0005840 272634 uuuggugcccaugucgcuguggaaacaccugguuccauuucgaacccagcaguuaagcacaguggagccgaauguagcugcagugagaauaggaaagcaccaagc <<<<<<<<.....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<..<<....<<..>>.....>>.>>...>>>>>>>>. .(((((((.....((((((((.....((((((...(.....)...))))..))....)))))).)).((......................))...))))))).. 70S ribosome with EF-G, A*- and P/E-site tRNAs in Mycoplasma pneumoniae cells; 5S ribosomal RNA 7pao 5 1493 7.0 RF00177,RF01959,RF01960 URS00019B76CF_272634 36171285 0003735 0005840 272634 ucugagaguuugauccuggcucaggauuaacgcuggcggcaugccuaauacaugcaagucgaucgaaaguaguaauacuuuagaggcgaacgggugaguaacacguauccaaucuaccuuauaaugggggauaacuaguugaaagacuagcuaauaccgcauaagaacuuugguucgaaucaaaguugaaaggaccugcaaggguucguuauuugaugagggugcgccauaucagcuaguuggugggguaacggccuaccaaggcaaugacguguagcuaugcugagaaguagaauagccacaaugggacugagacacggcccauacuccuacgggaggcagcaguagggaauuuuucacaaugagcgaaagcuugauggagcaaugccgcgugaacgaugaaggucuuuaagauuguaaaguucuuuuauuugggaagaaugacuuuagcagguaauggcuagaguuugacuguaccauuuugaauaagugacgacuaacuaugugccagcagucgcgguaauacauaggucgcaagcguuauccggauuuauugggcguaaagcaagcgcaggcggauugaaaagucugguguuaaaggcagcugcuuaacaguuguaugcauuggaaacuauuaaucuagagugugguagggaguuuuggaauuucauguggagcggugaaaugcguagauauaugaaggaacaccaguggcgaaggcgaaaacuuaggccauuacugacgcuuaggcuugaaaguguggggagcaaauaggauuagauacccuaguaguccacaccguaaacgauagauacuagcugucggggcgauccccucgguagugaaguuaacacauuaaguaucucgccuggguaguacauucgcaagaaugaaacucaaacggaauugacggggacccgcacaagugguggagcauguugcuuaauucgacgguacacgaaaaaccuuaccuagacuugacauccuuggcaaaguuauggaaacauaaugccgagugacagguggugcaugguugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuuaucguuaguuacauugucuagcgagacugcuaaugcaaauuggaggaaggaagggaugacgucaaaucaucaugccccuuaugucuagggcugcaaacgugcuacaauggccaauacaaacagucgccagcuuguaaaagugagcaaaucuguaaaguuggucucaguucggauugagggcugcaauucguccucaugaagucggaaucacuaguaaucgcgaaucagcuaugucgcggugaauacguucucgggucuuguacacaccgcccgucaaacuaugaaagcugguaauauuuaaaaacguguugcuaaccauuaggaagcgcaugucaaggauagcaccggugauuggaguuaagucguaacaagguaccccuacgagaacguggggguggauca .....<<<<..[.((([.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<<<<<....>>>>>>.>>>>>......<<........<<<.<<<..<<...<..<<<<<<.<<.....<<<<<<....>>>>>>......>>.>.....<<<<<<<<......>>>>>>>>....<<<<<<....>>>>>>>>>>>..>..>>>>>.>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>...>>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>......<..<<<....<<<<....>>>>..>>>.>>>.>>>>>>..<<<<......<<<<.....>>>>.....>>>>...<<..<<<.......<<<<<<<<<........>>>>>>>>>........>>>...>>.....<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<..<<<<<<<<<<.....<<<<<<<.....>>>>>>>..>>>>>>>>..>>.>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<<..<<<......>>>.....>>>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<......>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<.....<<<<<....>>>>>...>>>..].))).]<<<<<.<<<<<<<.<<..<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<......<<<<<<....>>>>>>...>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<.........>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>....>>>>>>>......<..<.<<<<<<<........>>>>>>>>...>.....>>>>>.....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<..<<<<<....<<<<<.<<<<..<<....>>.>>>>>>>>>...>>>>>..>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(....(((..((.((((((....)))))).)))))........(.......((...((..((...(..((((((.((.....(((((......)))))......)).).....(((((((........)))))))....((((((....)))))))))))..)..))))...)).((.....(((..((((((((.......))))))))))).......))..((((((((....))))...)))))...(((((............))))).((((....))).)....)))).)....((.(((...(((((....)))).)))))))).))))))..((((......((((.....)))).....))))....(..(((...(....(((.((((........)))).)).)...)....)))...)......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((....((.((((((..(((((..(((.....(((.(((.....))).)))..)))..)))..)).))))))..((((((((....((((((((....(((((.(...((........))......).)))))....).......((....)).)))))))...)))).)))..)))....))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((.((......)).)))))))...((..]])).....)))))))))).(((.......(((....))).....)))....]]].]((((..(((((((.....((((...((((.(.(((......((........))..........(((((.(..(...((.((........(..(....)..).....))..))).((.((....((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((.........)))))))..(..(((((....))))).....)..)))).....).).)))...))..))))....).)))))...)).).).)))).(...((((((......(((..(((..(((....))).).))....))).....))))))......(.....((((((........)))))).....)..)...)))).....(((((((..........)))))))...........))))))).)).))..(.(..((.(.((((...(...(((((..(((......((((((.(((..((....)).))))))))).....)))..)))))...)...))))..).))...)..)..(((((.(((....))).)))))}..... 70S ribosome with EF-G, A*- and P/E-site tRNAs in Mycoplasma pneumoniae cells; 16S ribosomal RNA 7pao 6 76 7.0 RF00005 URS000054164D_272634 36171285 0030533 0006412 272634 ggucuuguagcucagucgguagagcaacggucugaagaaccgugugucggcaguucgauucugcccgagaccacca <<<<<<<..<<<<........>>>>..<<<<.......>>>>......<<<<<.......>>>>>>>>>>>>.... .(.((((..((((........))))..((((.......))))......(((((.......)))))))))..).... 70S ribosome with EF-G, A*- and P/E-site tRNAs in Mycoplasma pneumoniae cells; tRNA-Phe 7pao 8 76 7.0 RF00005 URS000054164D_272634 36171285 0030533 0006412 272634 ggucuuguagcucagucgguagagcaacggucugaagaaccgugugucggcaguucgauucugcccgagaccacca <<<<<<<..<<<<........>>>>..<<<<.......>>>>......<<<<<.......>>>>>>>>>>>>.... .(.((((..((((........))))..((((.......))))......(((((.......)))))))))..).... 70S ribosome with EF-G, A*- and P/E-site tRNAs in Mycoplasma pneumoniae cells; tRNA-Phe 7paq 3 2878 8.9 RF02540,RF02541 URS0000AB9B3C_272634 36171285 0003735 0005840 272634 aguuacuaagggcuuaugguggaugccuuggcacuaauaggcgaugaaggacguguuaaccugcgauaagcuucggguaggugguaagaaccucagauccggagauuuccgaauggagcaauccgguaguuggaaacagcuaucauuaauugaugaauaaauagucaauuaaagcaauacguggugaagugaaacaucucaguagccacaggaaaagaaaacgaaugugauuccguguguaguggcgagcgaaagcggaacaggccaaacuuaucauuagauagggguuguagggcuugcaauguggacuugaaaacgauagaagaagcuguuggaaagcagcgcgcaaaagggugauagccccguauuugaaauuguuuucauaccuagcgagaucccugaguagcucggaaaacguuauuuugagugaaucugcccagaccauuggguaagccuaaauacuaauuagugaccgauagcgaaacaguaccgugagggaaaggugaaaagaacccagagaugggagugaaauagauucugaaaccauaugccuacaacgugucagagcacauuaaugugugauggcgugcguuuugaaguaugagccggcgaguuaugauagcaagcguuaguuaaccaggagauggggagcuguagcgaaagcgaguuuuaaaagagcguuuguuuguuauuauagacccgaaacggguugagcuagucaugagcagguugaagguugaguaacaucaacuggaggaccgaaccgacucucguugaaacgauagcggaugacuugugauuaggggugaaauuccaaucgaaauccgugauagcugguucucgucgaaauagcuuuaaggcuagcgugagaucacaaauaaguggagguaaagcuacugaauguaugauggcgccggcguacugaauacaauuaaacucugaaugccauuuauuuuauucucgcagucagacagugggggauaagcuucauugucaagaggggaagagcccagaucauuaaauaagguccccaaaauauacuaaguggaaaaggaugugaaagugcuaaaacagcaaggauguuggcuuagaagcagccaucguuuaaagagugcguaacagcucacuugucgaguguuuuugcgccgaagauguaacggggcuaaguauauuaccgaauuuauggauaagauuuauaucuugugguagacgagcguuguauuggaguugaagucaaagcgugagcauugguggauccaauacaagugagaaugccggcaugaguaacgcuugggagugagaaucucccaaaccgauugacuaagguuuccuggaccagggucguccuuccaggguuagucuggaccuaagcugaggcugaaaagcguaggcgauggacaacagguuaauauuccuguacuuacaguuagacugauggagugacaaagaagguuuuccacccccauaauuggauuuggggauaaaucauaaggugguacaauaggcaaauccguugugcauaacauugagugaugaugucgagugaaaguagcgaaggugguauuaaucaugcuuucaagaaaagcuucuaggguuaaucuagcuguaaccaguaccgagaacgaacacacguagucaaggagaggauccuaagguuagcgagugaacuauagccaaggaacucugcaaauuaaccccguaaguuagcgagaaggggugcuuauguaaaaguaagccgcagugaagaacgaggggggacuguuuaacuaaaacacaacucuaugccaaaccguaaggugauguauauggggugacaccugcccagugcuggaagguuaaagaaggagguuagcgcaagcgaagcuuuuaacugaagccccagugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuagucggguaaauuccgucccgcuugaaugguguaaccaucucuugacugucucggcuauagacucggugaaauccagguacgggugaagacacccguuaggcgcaacgggacggaaagaccccgugaagcuuuacuguagcuuaauauugaucaggacauuaucauguagagaauagguaggagcaaucgaugcaaguucgcuaggacuuguugaugcgaaagguggaauacuacccuugguugugugcuguucuaauugguaacuguuauccaguuucaagacaguguuaggugggcaguuugacuggggcggucgccuccuaaaagguaacggaggcguacaaagguaccuucaguacgguuggaaaucguauguagaguguaaugguguaagggugcuugacugugagacauacaggucgaacaggugagaaaucaggucauagugauccggugguccaguauggaauggccaucgcucaacggauaaaagcuacuccggggauaacaggcugauacugcccaagaguucauaucgacggcaguguuuggcaccucgaugucgacucaucucauccucgagcugaagcagguucgaaggguucggcuguucgccgauuaaagagauacgugaguuggguucaaaccgucgugagacagguuggucccuaucuauugugcccguaggaagauugaagaguguugcuucuaguacgagaggaccgaagcgaggacaccucuuaugcuccaguuguagcgccagcugcaccgcuggguaguaacgugucuauuagauaaacgcugaaagcaucuaagugugaaacuaucucaaagauuaaucuucccauuucgcaagaaaguaagagccgucaaagacgaugacguugauagguuacagguguaagcauagugauauguugagcugaguaauacuaauugcucgaggacu .........<<<<.<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>....<<<<<<<<..<<<)))....>>>.....>>>>>>>.>.>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>....<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((....<<<<<<....>>>>>>......<<<<<<<<<...<.<<...<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>..>>>.>>>>>..>>>>.....<<<<<<<<.......>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<....>>>>.............}....>>>>>>.>>>>.......<<<<..<<<<......>>>>..>>>>...<<..........>>.<<<<<<....<<<<<<<<<<<<<...<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<.<<........>>.>>>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>..<<<<<<....<<<<<<<<<<.....<<<....<<..<<<<<...<.<<....>>..>...>>>>>..>>..>>.>.....>>>>>>>>>>...>>>>>>.....<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<....>>>>>>>....>>>>>><<<<<<<<<<<<......<<<<<.<<....>>.>>>>>...>>>>>>>>>>.>>.....>>>>>>.......<<...<<<<<<.......>>>>>><<<<....<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<.<...<<<<<...<<<<...<.<..<<<<<<<<<....(((...>>>>><<..<<<<<..<<<<<<<<<<<.<<.....>>>>>>>>>....>>>>..>>>>>...>>...<<.......>>....>>>>....>.>....>>>>........>>>>>..>......>>>>>>>>>>>>>>>..>>.....<<......>>.>>>>.<<<<.....>>>>..>>>>..<<<<<...<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<......>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>..<<<<.<<<..<<<<<<<..<<<<..<<..<<.<<<..<<....>>..>.>>>>...>>..>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<.<<<<.....>>>>.>.....>....>>>>...>>.>>>>>>>..>..>>.>>>>>>>>>>>>>>>...........<<<<<........>>>>>..<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<..<<<<<<<<..<<.<<<.<<<<.<<<<...........<<<<<..<<<......<<<<<<<......>>>>>>>...>>>.............>>>>>..>>>>.>>>>.>>>.>>...<<<..<<<<<.....>>>>>.>>>.....>>>>>>>>...>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>..........(((......>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>..>........<<<..<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>......>>>.......<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<<....<<<..<<<<<<<...............>>>>>>><<<<<<...<<<<...<<<<.<<<<<<.)))>>>>>>...>>>>...>>>>.>>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>........>>>>>>>..................<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....... ..........(((.(((((.....(((..(((((((((((((......(((((.....[[[..)).....((.(((...((.]]].....))......))).))...)))....(((....)))((((((((....)))))))).(((((((((.........))))))))).))....((((((.....(...[..)......))))).).........((....))...((((......(..]....).....))))...((((...(((((......)))))......(((((((((.....((...(((((((.((..((...(((((......)))))[[......(((.....]])))...))....)).)))))))..))..)))))..))))).....((((((((.[..).)))))))........((((].[[[[))))...)))......)).))))))).))...............((....))....)).........((((....)))).............).....))))).)))......(.(.((..((((..[...))))..)).).<.(.(........).).((((((....(((((((.(((((....(....(((.....)))....)....((....))..(.((.....)).)....))))).)))))))..((.....(((.((.....(.(((.((((.(((.....(((((......))))).....<)))...(((.((.((...(...))).)))))..).))).))).).(.((.......))...)..)).)))........))..((((((....(((((....)))))..((((((....((((((((((.....(((.....((.((((....(..(....)...)....)))).))...)).).....)))))))).))..)))))).....((((((((((......))))))))))....(((......)))....(((..((...((([[[....(.((((.....(.....((..(..(((((.(.....{..((((.(((..(((.........)))..))).....(...((......)).).))))....).)))))..).))...........]]].)...))))..))))...)).))).(.(((((....))))).)....))))))(((((((..(((........(((.((....))]))).....)))..))))).)).....)))))).......((...((((((.......)))))).(.(....(((...((..(((((((...((.....)).))))))....[[((((.((.(.((....(((....)))....))..)))...(((((........)))))]](((((((((((((...(((((...((((..((....(((((((((.....{{...)))))(...((((...((((..(((((.((.....)))))))......))))...))))....)(..(.........)...)))))......))...))))(..)....)))))...))....))))))))))))))).))).....((......))..))).((((.....))))..)..)..((((....((((((((.((..(....(.......(((((....(.[..).....)))))((((((......))))))(...).......(((((((((.>.((.........))...((((.((.....(((....))).......)).)))).]((((.(((..((.((((..(((...((....(.((..((....))...)).)....))...)))))))...)))))(.(((.........))).).........(..........(.(((.......))).)..).......))))...)).))))))).)..))).)))))))).))))))......).[..(((((.....>].)))))..(((.(((...((.((......((((.((((((..((((..((.(((((..((.(((.((...(.((.(......[..(((((..(((......((((((........))))))...)))...........].)))))).))..)..)).))).))...(((..(((((.....))))).))).....))))).))...))))..(((......[)))((((((..........]))))))(.((...((.(((..(..((((.........))))....)......[[[.......))).))...((((..(((...{..)))..)))).(((....))).))]]].......((((((..((..]]]]..)).)))))).....)}......))))..)))))).......((((.(.((((((...((.......))...))))))...)))).)........(.((..(((((..((.(((.(........).)))...)).(((((.....))))).....)))))......))..).....(((((((....))).))))....))..))..))).)))[...(((((((....(((..(((((((.....(....)....))))))).(((((...((((...((((.((((((.}}.))))))...))))...)))).)))))...(((....((((.....}.......))))....))).)))...]....)))))))(...(.......).....(((((((((.......)))))....((((((((..(......((((....)))).....)...))))).)))...))))...)... 70S ribosome with EF-G, A/P- and P/E-site tRNAs in Mycoplasma pneumoniae cells; 23S ribosomal RNA 7paq 4 105 8.9 RF00001 URS000000E851_272634 36171285 0003735 0005840 272634 uuuggugcccaugucgcuguggaaacaccugguuccauuucgaacccagcaguuaagcacaguggagccgaauguagcugcagugagaauaggaaagcaccaagc <<<<<<<<.....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<.......<<<..>>>.......>>...>>>>>>>>. ..(((.((.....((((((((.....((((((...(.....)...))))..))....)))))).)).((......................))...)).)).).. 70S ribosome with EF-G, A/P- and P/E-site tRNAs in Mycoplasma pneumoniae cells; 5S ribosomal RNA 7paq 5 1493 8.9 RF00177,RF01959,RF01960 URS00019B76CF_272634 36171285 0003735 0005840 272634 ucugagaguuugauccuggcucaggauuaacgcuggcggcaugccuaauacaugcaagucgaucgaaaguaguaauacuuuagaggcgaacgggugaguaacacguauccaaucuaccuuauaaugggggauaacuaguugaaagacuagcuaauaccgcauaagaacuuugguucgaaucaaaguugaaaggaccugcaaggguucguuauuugaugagggugcgccauaucagcuaguuggugggguaacggccuaccaaggcaaugacguguagcuaugcugagaaguagaauagccacaaugggacugagacacggcccauacuccuacgggaggcagcaguagggaauuuuucacaaugagcgaaagcuugauggagcaaugccgcgugaacgaugaaggucuuuaagauuguaaaguucuuuuauuugggaagaaugacuuuagcagguaauggcuagaguuugacuguaccauuuugaauaagugacgacuaacuaugugccagcagucgcgguaauacauaggucgcaagcguuauccggauuuauugggcguaaagcaagcgcaggcggauugaaaagucugguguuaaaggcagcugcuuaacaguuguaugcauuggaaacuauuaaucuagagugugguagggaguuuuggaauuucauguggagcggugaaaugcguagauauaugaaggaacaccaguggcgaaggcgaaaacuuaggccauuacugacgcuuaggcuugaaaguguggggagcaaauaggauuagauacccuaguaguccacaccguaaacgauagauacuagcugucggggcgauccccucgguagugaaguuaacacauuaaguaucucgccuggguaguacauucgcaagaaugaaacucaaacggaauugacggggacccgcacaagugguggagcauguugcuuaauucgacgguacacgaaaaaccuuaccuagacuugacauccuuggcaaaguuauggaaacauaaugccgagugacagguggugcaugguugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuuaucguuaguuacauugucuagcgagacugcuaaugcaaauuggaggaaggaagggaugacgucaaaucaucaugccccuuaugucuagggcugcaaacgugcuacaauggccaauacaaacagucgccagcuuguaaaagugagcaaaucuguaaaguuggucucaguucggauugagggcugcaauucguccucaugaagucggaaucacuaguaaucgcgaaucagcuaugucgcggugaauacguucucgggucuuguacacaccgcccgucaaacuaugaaagcugguaauauuuaaaaacguguugcuaaccauuaggaagcgcaugucaaggauagcaccggugauuggaguuaagucguaacaagguaccccuacgagaacguggggguggauca .....<<<<..[.((([.>>>>.<<<<.<<<<...<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<....>>>>>>.>>>>>......<<........<<<.<<<..<<...<..<<<<.<.<<.....<<<<<<....>>>>>>......>>.>.....<<<<<<<.<<.>>..>>>>>>>....<<<<<<....>>>>>>.>>>>..>..>>>>>.>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>...>>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<.....>>>>.....>>>>...<...<<<.......<<<<<<<<<........>>>>>>>>>........>>>....>.....<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>...>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<..<<<<<<<<<<.....<<<<<<<.....>>>>>>>..>>>>>>>>..>>.>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<<..<<<......>>>.....>>>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<......>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<.....<<<<<....>>>>>...>>>..].))).]<<<<<.<<<<<<<.<<..<<<<...<<<<<<<<<<......<<........>>..........<<<<<<<......<.<<<<.....<<<<<<....>>>>>>..>>>>..>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<...........>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<......>>>..>>....>>>....>>>>>>>......<....<<<<<<<........>>>>>>>....>......>>>>.....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<...<<<<<<..<<<<<....<<<<<<.<<<..<<....>>.>>>>>>>>>...>>>>>..>>>>>>...>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .....((((..[.[[[[.)))).(....(.(((...((((((((....(.(.(....(.(..((..(((((....)))).).))).)......(((.......(..((((..((...(..(((.((.((.....((((((....))))))......)).)........((((...()...)))).......((((((....))))))).)))..)..))))))..).(((....((...(((((.((.......)).))))).))......)))..(((((.((....)).)...))))))).(((((............))))).((((....)))).....)).).).....(.(((...(((((....)))).))))).)).)))))...((((......(.((.....)).).....))))....(..(((...(....(((.((((........)))).)))....)....)))...)......(.((([[[...(((((.....((.]]])).......)))))))).)..))).)...)..........((([[...(.((((...(((.(..(.(..(((((..((......(((.(((.....))).)))...))..)))..)).)..).)..((((.((((...(((((((.(...(((((((...((........))......)))))))....).......((....)).)))))))..))))..)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((...((.(((..(.......).))).))....((..]])).....)))))))))).(.(.......(((....))).....).)..].]]].](((.(..((((((.......(....((((((((((......((........))..........(((((((......((.((((......(..(....)...)..))))..))..((.((....((.(((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((.............)))))..(..(.(((....))).).....)..)))).....).).))....))..))))....)))))))...)).)))))))).(...(.((((......(((..((..((((....))))..))....))).....)))).)......(....(((((.(........).)))))....)..)....).......(((((((.(.....)..)))))))...........)))))).).).))..(.(..((.(.((((..((...(((((..(((((....((.(((.(((..((....)).)))))).))...)))).).)))))...))..))))..).))...)..)..(((((((((....)))))))))}..... 70S ribosome with EF-G, A/P- and P/E-site tRNAs in Mycoplasma pneumoniae cells; 16S ribosomal RNA 7paq 7 76 8.9 RF00005 URS000054164D_272634 36171285 0030533 0006412 272634 ggucuuguagcucagucgguagagcaacggucugaagaaccgugugucggcaguucgauucugcccgagaccacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((.(........).))..((((.......))))......(((((.......)))))))))))).... 70S ribosome with EF-G, A/P- and P/E-site tRNAs in Mycoplasma pneumoniae cells; tRNA-Phe 7paq 8 76 8.9 RF00005 URS000054164D_272634 36171285 0030533 0006412 272634 ggucuuguagcucagucgguagagcaacggucugaagaaccgugugucggcaguucgauucugcccgagaccacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((.(........).))..((((.......))))......(((((.......)))))))))))).... 70S ribosome with EF-G, A/P- and P/E-site tRNAs in Mycoplasma pneumoniae cells; tRNA-Phe 7par 3 2878 8.2 RF02540,RF02541 URS0000AB9B3C_272634 36171285 0003735 0005840 272634 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<<<......<<<<.<<<<<<....<<<..<<<<<<<<<<<<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>....<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<....<<<<<......>>>>>......<<<<<<<<<.....<....<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>...>..>>>>>..>>>>.....<<<<<<<<.......>>>>>>>>.......<<<<..<<<<>>>>...>>>......>>.>>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>.............>....>>>>>>.>>>>.......<<<<..<<<<......>>>>..>>>>...<<..........>>.<<<<<<....<<<<<<<<<<<<<...<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<.<<........>>.>>>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<....<<<<<<<<<<......<<....<<..<<<<<...<...<..>....>...>>>>>..>>..>>.......>>>>>>>>>>...>>>>>>.>>..<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<.........>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<....>>>>>>>....>>>>>><<<<<<<<<<<<......<<<<<.<<....>>.>>>>>...>>>>>>>>>>.>>.....>>>>>>.......<<...<<<<<<.......>>>>>>.<<<....<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<.<...<<<<<...<<<<...<<<..<<<<<<<<<....(((...>>>>><<..<<<<<..<<<<<<<<<<<.<<.....>>>>>>>>>....>>>>..>>>>>...>><..<<.......>>...>>>>>....>>>....>>>>........>>>>>..>......>>>>>>>>>>>>>>>..>>.....<<......>>.>>>>.<<<<.....>>>>..>>>...<<<<<...<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<......>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<..<<<<<<<.<<....>>..>>>>>>>..>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<.............<<<<.....>>>>.......>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>>>>>>>>...........<<<<<........>>>>>..<<<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<.<<<.<<<<..<<<...........<<<<<..<<<......<<<<<<<......>>>>>>>...>>>.............>>>>>..>>>..>>>>.>>>.>>...<<<..<<<<<.....>>>>>.>>>....>>>>>>>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>..........(((......>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..>>>>..>>>>>>>>>.............>>>>..>>>>>>.......<<<<..<<<<<<<...<<.......>>...>>>>>>>...>>>.>.......<.<<<..<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>......>>>..>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>>>....<<<<<<<....<<<..<<<<<<<...............>>>>>>><<<<<<...<<<<...<<<<<<<<<<<.)))>>>>>>..>>>>>...>>>>.>>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>........>>>>>>>..................<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((.......(((.((((((....(((..((((((((.((((......((((((....[[[.))).....((.(((....((]]]....).)......))).))...)))....(((....)))(.(((((.(...)))))).).(((((((((.........))))))))).))....((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...(((((......)))))......(((((((((.....((...(((((((.((.(((...(((((......)))))[[......(((.....]])))...)))...)).)))))))..))..)))))..))))).....((((.(((.[..).)).))))........((((]..[[[))))...)))......))..)))))).))...............((....))....)).........((((....)))).............)....)))))).)))......(.(.((..((((..[...))))..)).).<.(((........))).((((((....(((((((.(((((....(....(((.....)))....)....((....))..(.((.....)).)....))))).)))))))..((.(...((((((.....(.(((..(((.(((....((((((......)))))).....)))...(((.((.((........)).)))))..).))..))).).(.((.......))...)..))))))......).))..((((((....(((((....)))))(.((((((....((((((((((......((....(((.((((....(...........)....)))).)))..)).......))))))))))...))))))..)..((((.((..(......)..)).))))....(((......)))....(((.(((...((([[[....((((((.....(.....((..(..(((((.(.......(((((.(.(..(((.........)))..).).....(...((......)).).)))))...).)))))..).))...........]]].)...))))).))))...)))))).(((((((....)))))))....))))))(((((((..(((......(.(((.((....))]))).)...)))..))))).)).....)))))).....(.((...((((((.......))))))((.(....(.(...((..(((((((...((.....)).))))))....[[((((.((...((....(((....)))....))...))...(((((........)))))]](((((((((((((....((((...((((..(..(..(((((((((.....{{...)))))(...((((...(.((((((((..((.....)).))))))....)).)...))))....)(..(.........)...))))).....).)...))))(..)....))).)..)).....))))))))))))))).))).....((......))..).).((((.....))))..).))..((((....((((((((.((..(....(.......(((((....(.[..).....)))))(((((........)))))(...).......(.(((((((...((.........))...((.(.((.....(((....))).......)).).)).]((((.(((..((.((((..(((...((....(.((..((....))...)).)....))...)))))))...)))))(((((.........))))).........(..........(.(((.......))).)..).......))))...)).))))).).)..))).)))))))).))))))..)...).[..(((((.....>].)))))..((((((...(((.((......((((.((((((..((((..((((((.((.((.(((.(((....((.(......[..(((((..(((......(((((.((....)).)))))...)))...........].)))))).))....))).))).))...(((..(((((.....))))).)))....)).))))))...))))..(.(......[).)((((((..........]))))))(.((...((.(((..(..((((.........))))....)....[.[[[.......))).))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]...))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....))..)))..))))))[...(((((((....(((..(((((((.....(....)....)))))))..((((...((((...((((.((((((.}}.))))))...))))...)))).))))....(((....((.(.............).))....))).)))...]....)))))))(...(.......).....(((((((((.......)))))....((((((((.((......((((....)))).....))..))))).)))...))))...)))) 70S ribosome with EF-G, ap/P- and pe/E-site tRNAs in Mycoplasma pneumoniae cells; 23S ribosomal RNA 7par 4 105 8.2 RF00001 URS000000E851_272634 36171285 0003735 0005840 272634 uuuggugcccaugucgcuguggaaacaccugguuccauuucgaacccagcaguuaagcacaguggagccgaauguagcugcagugagaauaggaaagcaccaagc <<<<<<<<.....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<..<<...<<<..>>>....>>.>>...>>>>>>>>. .(((((((.....((((((((.....((((((...(.....)...))))..))....)))))).)).((...(...(......)....)..))...))))))).. 70S ribosome with EF-G, ap/P- and pe/E-site tRNAs in Mycoplasma pneumoniae cells; 5S ribosomal RNA 7par 5 1493 8.2 RF00177,RF01959,RF01960 URS00019B76CF_272634 36171285 0003735 0005840 272634 ucugagaguuugauccuggcucaggauuaacgcuggcggcaugccuaauacaugcaagucgaucgaaaguaguaauacuuuagaggcgaacgggugaguaacacguauccaaucuaccuuauaaugggggauaacuaguugaaagacuagcuaauaccgcauaagaacuuugguucgaaucaaaguugaaaggaccugcaaggguucguuauuugaugagggugcgccauaucagcuaguuggugggguaacggccuaccaaggcaaugacguguagcuaugcugagaaguagaauagccacaaugggacugagacacggcccauacuccuacgggaggcagcaguagggaauuuuucacaaugagcgaaagcuugauggagcaaugccgcgugaacgaugaaggucuuuaagauuguaaaguucuuuuauuugggaagaaugacuuuagcagguaauggcuagaguuugacuguaccauuuugaauaagugacgacuaacuaugugccagcagucgcgguaauacauaggucgcaagcguuauccggauuuauugggcguaaagcaagcgcaggcggauugaaaagucugguguuaaaggcagcugcuuaacaguuguaugcauuggaaacuauuaaucuagagugugguagggaguuuuggaauuucauguggagcggugaaaugcguagauauaugaaggaacaccaguggcgaaggcgaaaacuuaggccauuacugacgcuuaggcuugaaaguguggggagcaaauaggauuagauacccuaguaguccacaccguaaacgauagauacuagcugucggggcgauccccucgguagugaaguuaacacauuaaguaucucgccuggguaguacauucgcaagaaugaaacucaaacggaauugacggggacccgcacaagugguggagcauguugcuuaauucgacgguacacgaaaaaccuuaccuagacuugacauccuuggcaaaguuauggaaacauaaugccgagugacagguggugcaugguugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuuaucguuaguuacauugucuagcgagacugcuaaugcaaauuggaggaaggaagggaugacgucaaaucaucaugccccuuaugucuagggcugcaaacgugcuacaauggccaauacaaacagucgccagcuuguaaaagugagcaaaucuguaaaguuggucucaguucggauugagggcugcaauucguccucaugaagucggaaucacuaguaaucgcgaaucagcuaugucgcggugaauacguucucgggucuuguacacaccgcccgucaaacuaugaaagcugguaauauuuaaaaacguguugcuaaccauuaggaagcgcaugucaaggauagcaccggugauuggaguuaagucguaacaagguaccccuacgagaacguggggguggauca .....<<<<....((([.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<....>>>>>>.>>>>>......<<........<<<<<<<..<<.......<<<.<.<<..<..<<<<<<....>>>>>>.....>>>.>.....<<<<<<<........>>>>>>>....<<<<<<....>>>>>>.>>>......>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<............>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<.......<<<.....>>>......>>>>...<...<<<.........<<<<<<<........>>>>>>>..........>>>....>.....<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<..<<<<<<<<<<.....<<<<<<<.....>>>>>>>..>>>>>>>>..>>.>>>>>>...<<<<<<<....<<<<<<<....<<<<<<<<<..<<<......>>>.....>>>>>>>>.>..........<<....>>.>>>>>>>...>>>>.>>>...>>>...>>>>....<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<......>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<<.....<<<<....>>>>...>>>>..].)))..<<<<<.<<<<<<<.<<..<<<<<..<<<<<<<<<.......<<........>>..........<<<<<<<......<<<<<......<<<<<<....>>>>>>...>>>.>>..<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<.........>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>....>>>>>>>....>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>.....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<...<<<<.<<<..<<<<<<..<<<<<....<<<<<<.<<<..<<....>>.>>>>>>>>>...>>>>>..>>>>>>..>>>.>>>>....>>...>.....<<<<<<<<<....>>>>>>>>>...... .....((((..[.[[[..)))).(((..(((((...((((((((....(((.(((..(((..((.((((((....)))))).)))))......(((........((((((..((.......(((((.((.....((((((....))))))......)).)......(.((((........))))..)....((((((....))))))))))......))))))))..(((....((...(((((.((.......)).))))).))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).)))))...((((.......(((.....)))......))))....(...((...(...(.(.(((((........)))).)).)...)....))....)......((((([[[...(((((.....((.]]])).......))))))))))..))))).)))..........((([[...(.((((...(((.((((.(..((((...(((.....(((.(((.....))).)))..)))...))..)).).))))..((((.(((....((((((((....(((((((...((........))......)))))))....).......((....)).)))))))...)))..)))..))))...))))....((((((...((...((((.........))))...))))))))..........((((((..(((((((..(.......).)))))))...((..]])).....)))))))))).(.(.......(((....))).....).)....]]].](((((..((((((.((..(......((((((((..(.....((........))..........(((((....(....(.((......(((.((....)).)))...))..).).((.((....((((((.(....((((((.((....))....(((......)))...)))))).....((.(.(((.(.(.........).).)))..(..(.(((....))).).....)..).)).....).).)))...))..))))......)))))...)..)))))))).(...(((((((.....(((..((...(((....)))...))....)))....)))))))......(....(((((((........)))))))....)..)......).....(((((((..........)))))))......))...)))))).))).))..(.(..((.(.(..(.(.(...(((((...(((......(((((.(((..((....)).)))))))).....)))...)))))...).).)..)..).))...)..)..(((((.(((....))).)))))...... 70S ribosome with EF-G, ap/P- and pe/E-site tRNAs in Mycoplasma pneumoniae cells; 16S ribosomal RNA 7par 7 76 8.2 RF00005 URS000054164D_272634 36171285 0030533 0006412 272634 ggucuuguagcucagucgguagagcaacggucugaagaaccgugugucggcaguucgauucugcccgagaccacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... .((((((..((((........))))..((((.......))))......(((((.......)))))))))).).... 70S ribosome with EF-G, ap/P- and pe/E-site tRNAs in Mycoplasma pneumoniae cells; tRNA-Phe 7par 8 76 8.2 RF00005 URS000054164D_272634 36171285 0030533 0006412 272634 ggucuuguagcucagucgguagagcaacggucugaagaaccgugugucggcaguucgauucugcccgagaccacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... .((((((..((((........))))..((((.......))))......(((((.......)))))))))).).... 70S ribosome with EF-G, ap/P- and pe/E-site tRNAs in Mycoplasma pneumoniae cells; tRNA-Phe 7pas 3 2878 16.0 RF02540,RF02541 URS0000AB9B3C_272634 36171285 0003735 0005840 272634 aguuacuaagggcuuaugguggaugccuuggcacuaauaggcgaugaaggacguguuaaccugcgauaagcuucggguaggugguaagaaccucagauccggagauuuccgaauggagcaauccgguaguuggaaacagcuaucauuaauugaugaauaaauagucaauuaaagcaauacguggugaagugaaacaucucaguagccacaggaaaagaaaacgaaugugauuccguguguaguggcgagcgaaagcggaacaggccaaacuuaucauuagauagggguuguagggcuugcaauguggacuugaaaacgauagaagaagcuguuggaaagcagcgcgcaaaagggugauagccccguauuugaaauuguuuucauaccuagcgagaucccugaguagcucggaaaacguuauuuugagugaaucugcccagaccauuggguaagccuaaauacuaauuagugaccgauagcgaaacaguaccgugagggaaaggugaaaagaacccagagaugggagugaaauagauucugaaaccauaugccuacaacgugucagagcacauuaaugugugauggcgugcguuuugaaguaugagccggcgaguuaugauagcaagcguuaguuaaccaggagauggggagcuguagcgaaagcgaguuuuaaaagagcguuuguuuguuauuauagacccgaaacggguugagcuagucaugagcagguugaagguugaguaacaucaacuggaggaccgaaccgacucucguugaaacgauagcggaugacuugugauuaggggugaaauuccaaucgaaauccgugauagcugguucucgucgaaauagcuuuaaggcuagcgugagaucacaaauaaguggagguaaagcuacugaauguaugauggcgccggcguacugaauacaauuaaacucugaaugccauuuauuuuauucucgcagucagacagugggggauaagcuucauugucaagaggggaagagcccagaucauuaaauaagguccccaaaauauacuaaguggaaaaggaugugaaagugcuaaaacagcaaggauguuggcuuagaagcagccaucguuuaaagagugcguaacagcucacuugucgaguguuuuugcgccgaagauguaacggggcuaaguauauuaccgaauuuauggauaagauuuauaucuugugguagacgagcguuguauuggaguugaagucaaagcgugagcauugguggauccaauacaagugagaaugccggcaugaguaacgcuugggagugagaaucucccaaaccgauugacuaagguuuccuggaccagggucguccuuccaggguuagucuggaccuaagcugaggcugaaaagcguaggcgauggacaacagguuaauauuccuguacuuacaguuagacugauggagugacaaagaagguuuuccacccccauaauuggauuuggggauaaaucauaaggugguacaauaggcaaauccguugugcauaacauugagugaugaugucgagugaaaguagcgaaggugguauuaaucaugcuuucaagaaaagcuucuaggguuaaucuagcuguaaccaguaccgagaacgaacacacguagucaaggagaggauccuaagguuagcgagugaacuauagccaaggaacucugcaaauuaaccccguaaguuagcgagaaggggugcuuauguaaaaguaagccgcagugaagaacgaggggggacuguuuaacuaaaacacaacucuaugccaaaccguaaggugauguauauggggugacaccugcccagugcuggaagguuaaagaaggagguuagcgcaagcgaagcuuuuaacugaagccccagugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuagucggguaaauuccgucccgcuugaaugguguaaccaucucuugacugucucggcuauagacucggugaaauccagguacgggugaagacacccguuaggcgcaacgggacggaaagaccccgugaagcuuuacuguagcuuaauauugaucaggacauuaucauguagagaauagguaggagcaaucgaugcaaguucgcuaggacuuguugaugcgaaagguggaauacuacccuugguugugugcuguucuaauugguaacuguuauccaguuucaagacaguguuaggugggcaguuugacuggggcggucgccuccuaaaagguaacggaggcguacaaagguaccuucaguacgguuggaaaucguauguagaguguaaugguguaagggugcuugacugugagacauacaggucgaacaggugagaaaucaggucauagugauccggugguccaguauggaauggccaucgcucaacggauaaaagcuacuccggggauaacaggcugauacugcccaagaguucauaucgacggcaguguuuggcaccucgaugucgacucaucucauccucgagcugaagcagguucgaaggguucggcuguucgccgauuaaagagauacgugaguuggguucaaaccgucgugagacagguuggucccuaucuauugugcccguaggaagauugaagaguguugcuucuaguacgagaggaccgaagcgaggacaccucuuaugcuccaguuguagcgccagcugcaccgcuggguaguaacgugucuauuagauaaacgcugaaagcaucuaagugugaaacuaucucaaagauuaaucuucccauuucgcaagaaaguaagagccgucaaagacgaugacguugauagguuacagguguaagcauagugauauguugagcugaguaauacuaauugcucgaggacu .<.......<<<<.<<<<<<.....<<.<<<<<<<<<<..<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>....<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<.....<<<<......>>>>.......<<<<<<<<<..........<<<<<<<<<<.<<<....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>......>>>>>..>>>>.....<<<<<<<<.......>>>>>>>>......<<<<<...[[.>>>>>..>>>.........>>>>>>>.>>>..............<<....>>....>>.........<<<<....>>>>..................>>>>>>.>>>>.......<<<<..<<<<......>>>>..>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<....<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<.<<........>>.>>>>>....>>>>>>>>>>..<<.......>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><..<<<<<.....<<<<<<..<............<<..<<<<<...<.<<<..>>>..>...>>>>>..>>............>.>>>>>>....>>>>>...>..<<<<<<<<<........>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((....<<<<<<...........<<..<<<<<<<.<.........<.<..<<...<<<.........>>>...>>.........<<......>>....>.>.....>.>>>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>>.<<<<<<....>>>>>>.....>>>>>><<<<<<<<.<<<.......<<<<.<<....>>.>>>>....>>>.>>>>>>.>>.....>>>>>>.......((...<<<<<<.......>>>>>>[.......<<<<<.((...<<<<<<...<<.....>>.>>>>>>....((<<<..<<...<<<...<<<....>>>...>>>...>>....<<<<........>>>>.))..<<<<<<<......((<<<<...((.[...((...<<<<<<<<<....<<<...>>>>>.<..<<<<<...<<<.<<<<<<.<<.....>>>>>>>>.....>>>...>>>>>...>.<..<<.......>>...>>>>>.....)).....]))........>>>>.)).........>>>>>>>...>>>..)).....<<......>>>>>>>.<<<<.....>>>>....]...<<<<<...<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<......>>>>>>............<<<<<<.<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>..<<<<.<<<..<<<<<<<..<<....<<..<..<.<..<<....>>...>.>.>...>>....>>>>>>>..>>>>>.<<<<<.......>>>>>.........<...........<.<<<<.....>>>>.>.....>....>>>>...>>..>>>>>>.....>>.>>>>>>>>>>>>>))...........<<<<<........>>>>>..<<<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<..<<.<<<.<<<....<<...........<<<<<..<<.......<<<<<<........>>>>>>....>>.............>>>>>..>>....>>>.>>>.>>...<<<..<<<<<.....>>>>>.>>>.....>>>>>>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<....<<<<<<<...<<<<<<.......>>>>>>.....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>..>))).......<<<<<<<.<<...].]..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.........<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>......>>>.......<<<<<<<....>>>.>>>>....>>..>>>.>>>>>>>....<<<<<<<....(((...<<<<<<...............>>>>>>.<<<<<<...<<<<...<<<<<<<<<<<.>>>>>>>>>..>>>>>...>>>>.>>>>>>..<<<.<..<<<<<...........>>>>>...>>>>.)))........>>>>>>>..................<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>.....>. .........((((.(((((.....(((..(((((((((.(((......(((((.....[[[..))....(((.(((...(((]]]....)))......))).)).).)))....(((....)))(((((.((....)).)))))..(((((((...........)))))))..))....((.(((.....(...[..)......))).).).........((....))...(((((.....((.]...))....)))))...((((...(((..........)))......(((((((((.....(....((((((((((..((...(((((......)))))[[......(((.....]])))...))....))))))))))..)...)))))..))))).....(.(((((..[....))))).)........((((].[...))))...)))......)..))))))).))...............((....))....)).........((((....)))).............).....))))).)))).....(.((((...(((..[...)))...))))...(.(........).).(.((((....(((((((.(((((....(....(((.....)))....)....((....))..(.(.......).)....))))).)))))))..((.(...((((((.....(.(((.((((.((((....(((((......)))))...).{)))...(((.((.((........)).)))))..).))).))).).(.((.......))...)..))))))......).))..((((......(((((....))))).(.(((((......((((...(.....((.....(((...(((...(...(.).....)...)))...)))...).)......)..)))).....)))))..)...(((((((.((......)).)))))))....(((......)))...((((.(((...((([[[...(((((((.....(.....((..(..(.....(........((.(.(.(..(((.........)))..).).....(...((......)).).).))....).....)..).))...........]]].)...))))))))))...)))))))(.(((((....))))).)......))))(((((((..(((.......((((.((....))]))))....)))..))))).)).....)))).).......((...((((((.......))))))(.............(....((((((...((.....)).))))))....(....[.((.(.((....(((....)))....))..)))....((((........))))..)....((((........(.((....(......(......(((((((..........)))))....(((((...((...(.((..((.....)).)).).......))...)))))........((.......))....)).........)......)(..)......)))............))))....]......).....((......))......((((.....)))).....)..((((....((((((((.((..(....(.......(((((....(.[..).....)))))((((((......))))))(...).......((((.(.((.}.((.........))...((.((((.....(((....))).......)))).)).](.((.(((..((.((((..((....((....(.(...((....))....).)....))....))))))...)))))(((((.........))))).........(..........(.(((.......))).)..).......)).)...))..).)))).)..))).)))))))).))))))......).[..(((((......].)))))..((((((....((..(......((((.((((((..(((((.((((((.(..((.(((.((((.(.((.(......[..(((((..(((......(((((.(.......))))))...)))...........].)))))).))..))))).))).))...(((..(((((.....))))).))).....).))))))..)))))..(((......[)))((((((..........]))))))(..(...((((((..(.(((((.........)))))...).((...[.[)).....))))))...((((..(((...{..)))..)))).(((....))).).].].......((((((..((.....]..)).)))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..((.(((.((......)).)))...)).(((((.....))))).....)))))..)...))).).....(((((((....))).)))).....)..))...))))))[...(((.(((....(((..(((((((.....(....)....))))))).(((((...(((....((.((((..((....))..))..)).))....))).)))))...(((....((((.............))))....))).)))...]....))).)))(.................(((((((((.......)))))....((((((((..(......((((....)))).....)...))))).)))...))))...)... 70S ribosome with P/E-site tRNA in Mycoplasma pneumoniae cells; 23S ribosomal RNA 7pas 4 105 16.0 RF00001 URS000000E851_272634 36171285 0003735 0005840 272634 uuuggugcccaugucgcuguggaaacaccugguuccauuucgaacccagcaguuaagcacaguggagccgaauguagcugcagugagaauaggaaagcaccaagc .<.<<<<<.....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<.......<......>.......>>...>>>>>.>.. ....(........((.(((((.....((((((...(.....)...))))..))....)))))..))..(.......(......).......)........).... 70S ribosome with P/E-site tRNA in Mycoplasma pneumoniae cells; 5S ribosomal RNA 7pas 5 1493 16.0 RF00177,RF01959,RF01960 URS00019B76CF_272634 36171285 0003735 0005840 272634 ucugagaguuugauccuggcucaggauuaacgcuggcggcaugccuaauacaugcaagucgaucgaaaguaguaauacuuuagaggcgaacgggugaguaacacguauccaaucuaccuuauaaugggggauaacuaguugaaagacuagcuaauaccgcauaagaacuuugguucgaaucaaaguugaaaggaccugcaaggguucguuauuugaugagggugcgccauaucagcuaguuggugggguaacggccuaccaaggcaaugacguguagcuaugcugagaaguagaauagccacaaugggacugagacacggcccauacuccuacgggaggcagcaguagggaauuuuucacaaugagcgaaagcuugauggagcaaugccgcgugaacgaugaaggucuuuaagauuguaaaguucuuuuauuugggaagaaugacuuuagcagguaauggcuagaguuugacuguaccauuuugaauaagugacgacuaacuaugugccagcagucgcgguaauacauaggucgcaagcguuauccggauuuauugggcguaaagcaagcgcaggcggauugaaaagucugguguuaaaggcagcugcuuaacaguuguaugcauuggaaacuauuaaucuagagugugguagggaguuuuggaauuucauguggagcggugaaaugcguagauauaugaaggaacaccaguggcgaaggcgaaaacuuaggccauuacugacgcuuaggcuugaaaguguggggagcaaauaggauuagauacccuaguaguccacaccguaaacgauagauacuagcugucggggcgauccccucgguagugaaguuaacacauuaaguaucucgccuggguaguacauucgcaagaaugaaacucaaacggaauugacggggacccgcacaagugguggagcauguugcuuaauucgacgguacacgaaaaaccuuaccuagacuugacauccuuggcaaaguuauggaaacauaaugccgagugacagguggugcaugguugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuuaucguuaguuacauugucuagcgagacugcuaaugcaaauuggaggaaggaagggaugacgucaaaucaucaugccccuuaugucuagggcugcaaacgugcuacaauggccaauacaaacagucgccagcuuguaaaagugagcaaaucuguaaaguuggucucaguucggauugagggcugcaauucguccucaugaagucggaaucacuaguaaucgcgaaucagcuaugucgcggugaauacguucucgggucuuguacacaccgcccgucaaacuaugaaagcugguaauauuuaaaaacguguugcuaaccauuaggaagcgcaugucaaggauagcaccggugauuggaguuaagucguaacaagguaccccuacgagaacguggggguggauca .....<<<<..[.(((..>>>>.<<<<.<<<<<..<<<<<<<<.<....<.......<<<..<<.<<<<<<....>>>>>>.>>>>>......<<........<<<<<<<..<<...<...<<<.<.<<.....<<<<<<....>>>>>>......>>.>.....<<<<<<<<<....>>>>>>>>>....<<<<<<....>>>>>>.>>>...>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<............>>>>>.<<<<<..>>>>>.......>..>.......<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<.......<<<.....>>>......>>>>.......<<<........<<<<<<<<........>>>>>>>>.........>>>..........<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<..<<<<<<<<<<.....<<<<<<<.....>>>>>>>..>>>>>>>>..>>.>>>>>>...<<<.<<<<...<<<<<<<....<<<<<.<<<..<<........>>.....>>>.>>>>>...........<<....>>.>>>>>>>..>>>>..>>>...>>>...>>>>...<<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..>.......<<<<<<..<<<<<<<<<<......>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<......<<<<<....>>>>>....>>....))).]<<<<<..<<<<<<.<<..<<<<...<<<<<.<<<<......<<........>>..........<<<<<<<......<<<<<........<<<<....>>>>.....>>>.>>.<<<.<<<..<<<<<<.<.....<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<.<...........>.>>>>.....<<<<<....>>>>>........>>>>.....>...>>>...>>>>>>>>>...>>>>>>>...>>.>>.>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>....>>>>>>>......<..<.<<<<<<..........>>>>>>>...>......>>>>.....<<<<<<<..........>>>>>>>......>>...>>>>>>.>>>.>>....<.<.<...<<<<.<<...<<<<<<.....<.....<<<<<<.<<<..<<....>>.>>>>>>>>>...>......>>>>>>...>>.>>>>....>>...>.....<<<<<<<<<....>>>>>>>>>...... .....((((....[[[..)))).((......(.(.(((..((((..........(..(((..((.((((((....)))))).)))))......(((.......(....((...(...(....(..(.((.....((.((......)).))......)).)......(.(((...(...)..)))..)....(.((((....)))).)..)....)..).))....).((.....((...((((((((.......)))))))).)).......))..(((((.((....)).)...))))))).(((((............))))).((((....))))...).....)......(.(((.....(((....)))...)))).)).)..)))..(.((.......(((.....)))......)).)...((...((...(....((((((((........))))))))....)....))....)..)...((((([[[...(((((.....((.]]])).......))))))))))..)).....))..........((([[...(.((((....((.(....(..(((((((((......(((.(((.....))).)))...)))))))..)).)....)..((((.(((.....(((((((....(((((((...((........))......)))))))....).......((....)).))))))....)))..)))..)))....))))....((((((....(...((((.........))))...).))))))......{...((((((...((..((.((......)).))..))....((..]])).....)))))))))).(((......((((....))))....)))....]]]..((.((...((((..((..(((.....(((...(((......((........))........(.(.((.....(...((.(((.......(..(....)..)....)))..))).((.((....((((((.(....((((((.((....))....(((......)))...)))))).....((((.(((((.............)))))..(..(.(((....))).).....)..)))).....).).)))...))..)))).......)).))..)).)...)))..(...(.((((......(((..(((.((((....))))).))....))).....)))).)......(....(((((((........)))))))....)..)....))).....(((((((..........)))))))......))....))))..))..))..(.(..((.(...((..((..((((((..(........(((((..(((..((....)).))).))))).......)..))))))..))..))....).))...)..)..(((((((((....)))))))))}..... 70S ribosome with P/E-site tRNA in Mycoplasma pneumoniae cells; 16S ribosomal RNA 7pas 8 73 16.0 RF00005 URS000054164D_272634 36171285 0030533 0006412 272634 ggucuuguagcucagucgguagagcaacggucugaagaaccgugugucggcaguucgauucugcccgagacca .....<...<<<..........>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>.>...... .(....(..((............))..((((.......)))).......((((.......)))).).....). 70S ribosome with P/E-site tRNA in Mycoplasma pneumoniae cells; tRNA-Phe 7pat 3 2878 9.2 RF02540,RF02541 URS0000AB9B3C_272634 36171285 0003735 0005840 272634 aguuacuaagggcuuaugguggaugccuuggcacuaauaggcgaugaaggacguguuaaccugcgauaagcuucggguaggugguaagaaccucagauccggagauuuccgaauggagcaauccgguaguuggaaacagcuaucauuaauugaugaauaaauagucaauuaaagcaauacguggugaagugaaacaucucaguagccacaggaaaagaaaacgaaugugauuccguguguaguggcgagcgaaagcggaacaggccaaacuuaucauuagauagggguuguagggcuugcaauguggacuugaaaacgauagaagaagcuguuggaaagcagcgcgcaaaagggugauagccccguauuugaaauuguuuucauaccuagcgagaucccugaguagcucggaaaacguuauuuugagugaaucugcccagaccauuggguaagccuaaauacuaauuagugaccgauagcgaaacaguaccgugagggaaaggugaaaagaacccagagaugggagugaaauagauucugaaaccauaugccuacaacgugucagagcacauuaaugugugauggcgugcguuuugaaguaugagccggcgaguuaugauagcaagcguuaguuaaccaggagauggggagcuguagcgaaagcgaguuuuaaaagagcguuuguuuguuauuauagacccgaaacggguugagcuagucaugagcagguugaagguugaguaacaucaacuggaggaccgaaccgacucucguugaaacgauagcggaugacuugugauuaggggugaaauuccaaucgaaauccgugauagcugguucucgucgaaauagcuuuaaggcuagcgugagaucacaaauaaguggagguaaagcuacugaauguaugauggcgccggcguacugaauacaauuaaacucugaaugccauuuauuuuauucucgcagucagacagugggggauaagcuucauugucaagaggggaagagcccagaucauuaaauaagguccccaaaauauacuaaguggaaaaggaugugaaagugcuaaaacagcaaggauguuggcuuagaagcagccaucguuuaaagagugcguaacagcucacuugucgaguguuuuugcgccgaagauguaacggggcuaaguauauuaccgaauuuauggauaagauuuauaucuugugguagacgagcguuguauuggaguugaagucaaagcgugagcauugguggauccaauacaagugagaaugccggcaugaguaacgcuugggagugagaaucucccaaaccgauugacuaagguuuccuggaccagggucguccuuccaggguuagucuggaccuaagcugaggcugaaaagcguaggcgauggacaacagguuaauauuccuguacuuacaguuagacugauggagugacaaagaagguuuuccacccccauaauuggauuuggggauaaaucauaaggugguacaauaggcaaauccguugugcauaacauugagugaugaugucgagugaaaguagcgaaggugguauuaaucaugcuuucaagaaaagcuucuaggguuaaucuagcuguaaccaguaccgagaacgaacacacguagucaaggagaggauccuaagguuagcgagugaacuauagccaaggaacucugcaaauuaaccccguaaguuagcgagaaggggugcuuauguaaaaguaagccgcagugaagaacgaggggggacuguuuaacuaaaacacaacucuaugccaaaccguaaggugauguauauggggugacaccugcccagugcuggaagguuaaagaaggagguuagcgcaagcgaagcuuuuaacugaagccccagugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuagucggguaaauuccgucccgcuugaaugguguaaccaucucuugacugucucggcuauagacucggugaaauccagguacgggugaagacacccguuaggcgcaacgggacggaaagaccccgugaagcuuuacuguagcuuaauauugaucaggacauuaucauguagagaauagguaggagcaaucgaugcaaguucgcuaggacuuguugaugcgaaagguggaauacuacccuugguugugugcuguucuaauugguaacuguuauccaguuucaagacaguguuaggugggcaguuugacuggggcggucgccuccuaaaagguaacggaggcguacaaagguaccuucaguacgguuggaaaucguauguagaguguaaugguguaagggugcuugacugugagacauacaggucgaacaggugagaaaucaggucauagugauccggugguccaguauggaauggccaucgcucaacggauaaaagcuacuccggggauaacaggcugauacugcccaagaguucauaucgacggcaguguuuggcaccucgaugucgacucaucucauccucgagcugaagcagguucgaaggguucggcuguucgccgauuaaagagauacgugaguuggguucaaaccgucgugagacagguuggucccuaucuauugugcccguaggaagauugaagaguguugcuucuaguacgagaggaccgaagcgaggacaccucuuaugcuccaguuguagcgccagcugcaccgcuggguaguaacgugucuauuagauaaacgcugaaagcaucuaagugugaaacuaucucaaagauuaaucuucccauuucgcaagaaaguaagagccgucaaagacgaugacguugauagguuacagguguaagcauagugauauguugagcugaguaauacuaauugcucgaggacu <<<......<<<<.<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>....<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((.....<<<<<....>>>>>.......<<<<<<<<<.....<<...<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>..>>..>>>>>..>>>>.....<<<<<<<<.......>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<....>>>>..................>>>>>>.>>>>.......<<<<..<<<<......>>>>..>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<...<<<...<<<.....>>>...>>>...<<....>>..<<.<.....>.>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>...>.>>>...<<<.<<.<<........>>.>>>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<....<<<<<<<<<<.....<<<....<<..<<<<<...<.<<<..>>>..>...>>>>>..>>..>>.>.....>>>>>>>.>>>..>>>>>>.>>..<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((....<<<<<<...........<<..<<.<<<<<<........<<<<<.<<...<<<.........>>>...>>.........<<......>>...>>>>>....>>>>>>.>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<....>>>>>>>....>>>>>><<<<<<<<<<<<......<<<<<.<<....>>.>>>>>...>>>>>>>>>>.>>.....>>>>>>.......<<...<<<<<<.......>>>>>>.<<<....<<<<..<<...<<<<<<...<<.....>>.>>>>>>......<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>...<<<<<<<<<<.<...<<<<<...<<<<...<<<..<<<<<<<<<....(((...>>>>><<..<<<<<..<<<<<<<<<<<.<<.....>>>>>>>>>....>>>>..>>>>>...>>...<<.......>>....>>>>....>>>....>>>>........>>>>>..>......>>>>>>>>>>.>>>>..>>.....<<......>>.>>>>.<<<<.....>>>>..>>>...<<<<<...<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<......>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>..<<<<.<<<..<<<<<<<..<<<...<<..<<.<<<<.<<....>>..>>>>.>>..>>...>>>>>>>>..>>>>><<<<<<<....>.>>>>>>........<...........<.<<<<.....>>>>.>.....>....>>>>...>>.>>>>>>>..>..>>.>>>>>>>>>>>>>>>...........<<<<<........>>>>>..<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<<.<<.<<<.<<<...<<<...........<<<<<..<<.......<<<<<<<......>>>>>>>....>>.............>>>>>..>>>...>>>.>>>.>>...<<<..<<<<<.....>>>>>.>>>....>>>>>>>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>..........(((......>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<<....<<<....<<<<<...............>>>>>..<<<<<<...<<<<...<<<<<<<<<<<.)))>>>>>>..>>>>>...>>>>.>>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>........>>>>>>>..................<<<<<<<<<.......>>>>>....<<<<<<<<.<<.....<<<<<....>>>>>....>>..>>>>>.>>>...>>>>....>>> (.........(((.(((((.....(((..(((((((((((((......((((((....[[[.))).....((.(((....((]]]....).)......))).))...)))....(((....)))(((((.((....)).)))))..(((((((...........)))))))..))....((((((.....(...[..)......))))).).........((....))...(((((.....(..]....)....)))))...((((.(.(((((......)))))..)...((((((.((.....((...(((((((.((..((...(((((......)))))[[......(((.....]])))...))....)).)))))))..))..)).))..)))))....(((((((((.[..).))))))))......(((((].[[[.)))))..)))......)).))))))).))...............((....))....))......(..((((....))))............)).....))))).)))......(.(.((..((((..[...))))..)).)...(((........))).((((((....(((((((.(((.(....(....(((.....)))....)....((....))..(.((.....)).)....).))).)))))))..((.(...((((((.....(((((..(((.(((.....(((((......))))).....<)))...(((.((.((........)).)))))..).))..))))).(.((.......))...)..))))))......).))..((((((....(((((....)))))..(.((((....(.(.((((((.....((.....(.(.((((....(.((.().))..)....)))).).)...).).....))))))..))...)))).).....((((.((..(......)..)).))))....(((......)))....(((.(((...((([[[...(((((((.....(.....((..(..(((((((.....{.(((((.(.(..(((.........)))..).).....(...((......)).).)))))...)))))).).).))...........]]].)...))))))))))...)))))).(.(((((....))))).)....))))))((((((...(((........(((.((....))]))).....)))...)))).)).....)))))).......((...((((((.......)))))).(.(....(((...((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](.(((((((((.....(.(((...((((..(..(....(((((((.....{{...)))))((..(((((..(((((.((((..((.....)).)))).)....))))..)))))...))...((.......))....)).......).)...))))(..)....))).).........))))))))).))))).))).....((......))..))).((((.....))))..)..)..((((....((((((((.((..(............(((((....(.[..).....)))))((((((......))))))(...).......((((.(.((.>.((.........))...(((((((.....(((....))).......))))))).]((((.(((..(((((((..(((...((....((((..((....))...))))....))...))))))))..)))))((((((......).))))).........(..........(.(((.......))).)..).......))))...))..).))))....))).)))))))).))))))......).[..(((((......].)))).).((((((...(((.((......((((.((((((..(((((..(.((((((.((.(((.(((....((.(......[..(((((..(((.......(((((........)))))....)))...........].)))))).))....))).))).))...(((..(((((.....))))).)))....)))))).)...)))))..(((......[)))((((((..........]))))))(.((...(((((((.(.(((((.........)))))...)....[.[[[......)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....((((((..((...]]]..)).)))))).....)}......))))..)))))).......(((..(.((((((...((.......))...))))))...).)).)........(.((.((((((..((((((.((......)).)))..))).(((((.....))))).....)))))..)...))..).....(((((((....))).))))....))..)))..))))))[...(((((((....(((..(.(((((.....(....)....))))).).(((((...((((...((((.((((((.}}.))))))...))))...)))).)))))...(((....((((.....}.......))))....))).)))...]....)))))))(.................(((((((((.......)))))....((((((((..(......((((....)))).....)...))))).)))...))))...)..) free 50S in untreated Mycoplasma pneumoniae cells; 23S ribosomal RNA 7pat 4 105 9.2 RF00001 URS000000E851_272634 36171285 0003735 0005840 272634 uuuggugcccaugucgcuguggaaacaccugguuccauuucgaacccagcaguuaagcacaguggagccgaauguagcugcagugagaauaggaaagcaccaagc <<<<<<<<.....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<.......<<<..>>>.......>>...>>>>>>>>. (((((((......(((((((.(....((((((...(.....)...))))..))....)))))).)).((.......(......).......))....))))))). free 50S in untreated Mycoplasma pneumoniae cells; 5S ribosomal RNA 7pau 3 2878 8.3 RF02540,RF02541 URS0000AB9B3C_272634 36171285 0003735 0005840 272634 aguuacuaagggcuuaugguggaugccuuggcacuaauaggcgaugaaggacguguuaaccugcgauaagcuucggguaggugguaagaaccucagauccggagauuuccgaauggagcaauccgguaguuggaaacagcuaucauuaauugaugaauaaauagucaauuaaagcaauacguggugaagugaaacaucucaguagccacaggaaaagaaaacgaaugugauuccguguguaguggcgagcgaaagcggaacaggccaaacuuaucauuagauagggguuguagggcuugcaauguggacuugaaaacgauagaagaagcuguuggaaagcagcgcgcaaaagggugauagccccguauuugaaauuguuuucauaccuagcgagaucccugaguagcucggaaaacguuauuuugagugaaucugcccagaccauuggguaagccuaaauacuaauuagugaccgauagcgaaacaguaccgugagggaaaggugaaaagaacccagagaugggagugaaauagauucugaaaccauaugccuacaacgugucagagcacauuaaugugugauggcgugcguuuugaaguaugagccggcgaguuaugauagcaagcguuaguuaaccaggagauggggagcuguagcgaaagcgaguuuuaaaagagcguuuguuuguuauuauagacccgaaacggguugagcuagucaugagcagguugaagguugaguaacaucaacuggaggaccgaaccgacucucguugaaacgauagcggaugacuugugauuaggggugaaauuccaaucgaaauccgugauagcugguucucgucgaaauagcuuuaaggcuagcgugagaucacaaauaaguggagguaaagcuacugaauguaugauggcgccggcguacugaauacaauuaaacucugaaugccauuuauuuuauucucgcagucagacagugggggauaagcuucauugucaagaggggaagagcccagaucauuaaauaagguccccaaaauauacuaaguggaaaaggaugugaaagugcuaaaacagcaaggauguuggcuuagaagcagccaucguuuaaagagugcguaacagcucacuugucgaguguuuuugcgccgaagauguaacggggcuaaguauauuaccgaauuuauggauaagauuuauaucuugugguagacgagcguuguauuggaguugaagucaaagcgugagcauugguggauccaauacaagugagaaugccggcaugaguaacgcuugggagugagaaucucccaaaccgauugacuaagguuuccuggaccagggucguccuuccaggguuagucuggaccuaagcugaggcugaaaagcguaggcgauggacaacagguuaauauuccuguacuuacaguuagacugauggagugacaaagaagguuuuccacccccauaauuggauuuggggauaaaucauaaggugguacaauaggcaaauccguugugcauaacauugagugaugaugucgagugaaaguagcgaaggugguauuaaucaugcuuucaagaaaagcuucuaggguuaaucuagcuguaaccaguaccgagaacgaacacacguagucaaggagaggauccuaagguuagcgagugaacuauagccaaggaacucugcaaauuaaccccguaaguuagcgagaaggggugcuuauguaaaaguaagccgcagugaagaacgaggggggacuguuuaacuaaaacacaacucuaugccaaaccguaaggugauguauauggggugacaccugcccagugcuggaagguuaaagaaggagguuagcgcaagcgaagcuuuuaacugaagccccagugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuagucggguaaauuccgucccgcuugaaugguguaaccaucucuugacugucucggcuauagacucggugaaauccagguacgggugaagacacccguuaggcgcaacgggacggaaagaccccgugaagcuuuacuguagcuuaauauugaucaggacauuaucauguagagaauagguaggagcaaucgaugcaaguucgcuaggacuuguugaugcgaaagguggaauacuacccuugguugugugcuguucuaauugguaacuguuauccaguuucaagacaguguuaggugggcaguuugacuggggcggucgccuccuaaaagguaacggaggcguacaaagguaccuucaguacgguuggaaaucguauguagaguguaaugguguaagggugcuugacugugagacauacaggucgaacaggugagaaaucaggucauagugauccggugguccaguauggaauggccaucgcucaacggauaaaagcuacuccggggauaacaggcugauacugcccaagaguucauaucgacggcaguguuuggcaccucgaugucgacucaucucauccucgagcugaagcagguucgaaggguucggcuguucgccgauuaaagagauacgugaguuggguucaaaccgucgugagacagguuggucccuaucuauugugcccguaggaagauugaagaguguugcuucuaguacgagaggaccgaagcgaggacaccucuuaugcuccaguuguagcgccagcugcaccgcuggguaguaacgugucuauuagauaaacgcugaaagcaucuaagugugaaacuaucucaaagauuaaucuucccauuucgcaagaaaguaagagccgucaaagacgaugacguugauagguuacagguguaagcauagugauauguugagcugaguaauacuaauugcucgaggacu <<<......<<<<.<<<<<<....<<<..<<<<<<<<<<<<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>....<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<....<<<<<......>>>>>......<<<<<<<<<...<.<<...<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>..>>>.>>>>>..>>>>.....<<<<<<<<.......>>>>>>>>.......<<<<..<<<<>>>>...>>>......>>.>>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>.............>....>>>>>>.>>>>.......<<<<..<<<<......>>>>..>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<...<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>...>.>>>...<<<.<<.<<........>>.>>>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<....<<<<<<<<<<......<<....<<..<<<<<...<....<>.....>...>>>>>..>>..>>.......>>>>>>>>>>...>>>>>>.>>..<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((....<<<<<<...........<<..<<<<<<<.<........<<<<<.<<...<<<.........>>>...>>.........<<......>>...>>>>>....>.>>>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<....>>>>>>>....>>>>>><<<<<<<<<<<<......<<<<<.<<....>>.>>>>>...>>>>>>>>>>.>>.....>>>>>>.......<<...<<<<<<.......>>>>>>.<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<.<...<<<<<...<<<<..<<<<..<<<<<<<<<.....[[...>>>>><<..<<<<<..<<<<.<<<<<<.<<.....>>>>>>>>.....>>>>..>>>>>...>>...<<.......>>....>>>>....>>>>...>>>>........>>>>.>.>......>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>...<<<<<...<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<......>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>..<<<<.<<<..<<<<<<<..<<<...<<..<<.<<<<.<<....>>..>>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<.<<<<.....>>>>.>.....>....>>>>...>>.>>>>>>>.....>>.>>>>>>>>>>>>>>>...........<<<<<........>>>>>..<<<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<.<<<.<<<<..<<<...........<<<<<..<<<......<<<<<<........>>>>>>...>>>.............>>>>>..>>>..>>>>.>>>.>>...<<<..<<<<<.....>>>>>.>>>....>>>>>>>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>........[.(((......>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.<<..>>>>..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>..>......<<<<<..<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>>>....<<<<<<<....<<<..<<<<<<<...............>>>>>>><<<<<<...<<<<...<<<<<<<<<<<.]].>>>>>>..>>>>>...>>>>.>>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>........>>>>>>>..................<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> ((.(.....((((.(((((.....(((..(((((((((((((......(((((.....[[[..)).....((.(((...(((]]]....)))......))).))...)))....(((....)))(((((.((....)).)))))..((((((((.........))))))).).))....((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...(((((......)))))......((((((.((.....((...((((((((((..((...(((((......)))))[[......(((.....]])))...))....))))))))))..))..)).))..)))))....(((((.(((.[..).)).))))).......((((].[[[[))))...)))......)).))))))).))...............((....))....)).........((((....)))).............).....))))).)))).....(.(.((..((((..[...))))..)).).<.(.(........).).((((((....(((.(((.(((.(....(....(((.....)))....)....((....))..(.((.....)).)....).))).))).)))..((.(...((((((.....((((((.(((.((((....(((((......)))))....).)))...(((.((.((........)).)))))..).)).)))))).(.((.......))...)..))))))......).))..((((((....(((((....)))))((((((((....((((((((((.....(((....(((..((((...(.(......)..)...))))..)))..)).).....))))))))))...)))))).))..(((((((..(......)..)))))))....(((......)))....(((.(((...((([[[...(((((((.....(.....((..(..(((...(.....{..((((.(((..(((.........)))..))).....(...((......)).).))))....)...)))..).))...........]]].)...))))))))))...)))))).(((((((....)))))))....))))))(.(((((..(((........(((.((....))]))).....)))..)))))..).....)))))).......((...((((((.......))))))((.(....(((...((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]]((((((((((.((...(((((...((((..((.(..(((((((((.....{{...)))))((..(((((..((((((((((..((.....)).))))))....))))..)))))...))(..((.......))...)))))....).))...))))(..)....)))))..))......)))))))))))))).))).....((......))..))).((((.....))))..).))..((((....((((((((.((..(....(.......(((((....(.[..).....)))))(((((........)))))(...).......((((((.((...((.........))...((((.((.....(((....))).......)).)))).]((((.(((..(((((((..(((...((.....(((..((....))...))).....))...))))))))..)))))(.(((.........))).)........((..........(.(((.......))).)..)..)....))))...))..)))))).)..))).)))))))).))))))......).[..(((((.....>].)))))..((((((....((.((......((((.((((((..(((((..((((((((.((.(((.(((...(((.(......[..(((((..((........((((..........)))).....))...........].)))))).)))...))).))).))...(((..(((((.....))))).)))....))))))))...)))))..(((......[)))((((((..........]))))))(.((...((.((((.(..(((((.......)))))....)......[[[......)))).))...((((..(((...{..)))..)))).(((....))).))]]].......((((((..((..]]]]..)).)))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......((((.((((((..((((((((........)))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....))..))...))))))[...(((((((....(((..(.(((((.....(....)....))))).).(((((...((((...(((((((((((.}}.))))))..)))))...)))).)))))....((....((((.....}.......))))....))..)))...]....)))))))(...(.......).....(((((((((.......)))))....((((((((.((.....(((((....)))))....))..))))).)))...))))...)))) free 50S in complex with ribosome recycling factor in untreated Mycoplasma pneumoniae cells; 23S ribosomal RNA 7pau 4 105 8.3 RF00001 URS000000E851_272634 36171285 0003735 0005840 272634 uuuggugcccaugucgcuguggaaacaccugguuccauuucgaacccagcaguuaagcacaguggagccgaauguagcugcagugagaauaggaaagcaccaagc <<<<<<<<.....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<.......<<<..>>>.......>>...>>>>>>>>. ((((((((.....((((((((.....((((((...(.....)...))))..))....)))))).)).((.......(.(...)).......))...)))))))). free 50S in complex with ribosome recycling factor in untreated Mycoplasma pneumoniae cells; 5S ribosomal RNA 7ph9 3 2878 8.7 RF02540,RF02541 URS0000AB9B3C_272634 36171285 0003735 0005840 272634 aguuacuaagggcuuaugguggaugccuuggcacuaauaggcgaugaaggacguguuaaccugcgauaagcuucggguaggugguaagaaccucagauccggagauuuccgaauggagcaauccgguaguuggaaacagcuaucauuaauugaugaauaaauagucaauuaaagcaauacguggugaagugaaacaucucaguagccacaggaaaagaaaacgaaugugauuccguguguaguggcgagcgaaagcggaacaggccaaacuuaucauuagauagggguuguagggcuugcaauguggacuugaaaacgauagaagaagcuguuggaaagcagcgcgcaaaagggugauagccccguauuugaaauuguuuucauaccuagcgagaucccugaguagcucggaaaacguuauuuugagugaaucugcccagaccauuggguaagccuaaauacuaauuagugaccgauagcgaaacaguaccgugagggaaaggugaaaagaacccagagaugggagugaaauagauucugaaaccauaugccuacaacgugucagagcacauuaaugugugauggcgugcguuuugaaguaugagccggcgaguuaugauagcaagcguuaguuaaccaggagauggggagcuguagcgaaagcgaguuuuaaaagagcguuuguuuguuauuauagacccgaaacggguugagcuagucaugagcagguugaagguugaguaacaucaacuggaggaccgaaccgacucucguugaaacgauagcggaugacuugugauuaggggugaaauuccaaucgaaauccgugauagcugguucucgucgaaauagcuuuaaggcuagcgugagaucacaaauaaguggagguaaagcuacugaauguaugauggcgccggcguacugaauacaauuaaacucugaaugccauuuauuuuauucucgcagucagacagugggggauaagcuucauugucaagaggggaagagcccagaucauuaaauaagguccccaaaauauacuaaguggaaaaggaugugaaagugcuaaaacagcaaggauguuggcuuagaagcagccaucguuuaaagagugcguaacagcucacuugucgaguguuuuugcgccgaagauguaacggggcuaaguauauuaccgaauuuauggauaagauuuauaucuugugguagacgagcguuguauuggaguugaagucaaagcgugagcauugguggauccaauacaagugagaaugccggcaugaguaacgcuugggagugagaaucucccaaaccgauugacuaagguuuccuggaccagggucguccuuccaggguuagucuggaccuaagcugaggcugaaaagcguaggcgauggacaacagguuaauauuccuguacuuacaguuagacugauggagugacaaagaagguuuuccacccccauaauuggauuuggggauaaaucauaaggugguacaauaggcaaauccguugugcauaacauugagugaugaugucgagugaaaguagcgaaggugguauuaaucaugcuuucaagaaaagcuucuaggguuaaucuagcuguaaccaguaccgagaacgaacacacguagucaaggagaggauccuaagguuagcgagugaacuauagccaaggaacucugcaaauuaaccccguaaguuagcgagaaggggugcuuauguaaaaguaagccgcagugaagaacgaggggggacuguuuaacuaaaacacaacucuaugccaaaccguaaggugauguauauggggugacaccugcccagugcuggaagguuaaagaaggagguuagcgcaagcgaagcuuuuaacugaagccccagugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuagucggguaaauuccgucccgcuugaaugguguaaccaucucuugacugucucggcuauagacucggugaaauccagguacgggugaagacacccguuaggcgcaacgggacggaaagaccccgugaagcuuuacuguagcuuaauauugaucaggacauuaucauguagagaauagguaggagcaaucgaugcaaguucgcuaggacuuguugaugcgaaagguggaauacuacccuugguugugugcuguucuaauugguaacuguuauccaguuucaagacaguguuaggugggcaguuugacuggggcggucgccuccuaaaagguaacggaggcguacaaagguaccuucaguacgguuggaaaucguauguagaguguaaugguguaagggugcuugacugugagacauacaggucgaacaggugagaaaucaggucauagugauccggugguccaguauggaauggccaucgcucaacggauaaaagcuacuccggggauaacaggcugauacugcccaagaguucauaucgacggcaguguuuggcaccucgaugucgacucaucucauccucgagcugaagcagguucgaaggguucggcuguucgccgauuaaagagauacgugaguuggguucaaaccgucgugagacagguuggucccuaucuauugugcccguaggaagauugaagaguguugcuucuaguacgagaggaccgaagcgaggacaccucuuaugcuccaguuguagcgccagcugcaccgcuggguaguaacgugucuauuagauaaacgcugaaagcaucuaagugugaaacuaucucaaagauuaaucuucccauuucgcaagaaaguaagagccgucaaagacgaugacguugauagguuacagguguaagcauagugauauguugagcugaguaauacuaauugcucgaggacu .<.......<<<<.<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<<<<.........>>>>>>>>.>>>....<<<<<......<<....>>.......>>>>.>.........<......>...<<<<<.....<<.....>>....>>>>>...(((....<<<<<......>>>>>......<<<<<<<<<.....<....<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>...>..>>>>>..>>>>.....<<<<.<<<.......>>>.>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<....>>>>.............}....>>>>>>.>>>>.......<<<<..<<<<......>>>>..>>>>...<<..........>>.<<<<<.....<<<<<<<<<<<<....<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<.<<........>>.>>>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<....<<<<<<<<<<.<....<<....<<..<<<<<.....<<<..>>>......>>>>>..>>..>>.....>.>>>>>>>>>>...>>>>>>..>..<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((....<<<<<<...........<<..<<.<<<<..........<<<<<.<<...<<<.........>>>...>>.........<<......>>...>>>>>......>>>>.>>.>>...........))).....>>>>>>.>>>...>>>>>>>.<<<<<<....>>>>>>.....>>>>>><.<<<<<<<<<<........<<<.<<....>>.>>>.....>>>>>>>>>>..>......>>>>>.......<....<<<<<<.......>>>>>>.<<<....<<....<<<..<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>....<<<<........>>>>.))<<<<<<<<<<..<...<<<<<...<<<<...<<<..<<<<<<<<<....(((...>>>>>....<<<<....<<<.<<<<<..<<.....>>.>>>>>.....>>>....>>>>.....<...<.......>....>>>>>....>>>....>>>>........>>>>.>.>.......>>>>>>>>>>>>>>.>>>.....<<......>>...>>.<<<<.....>>>>..>>>...<<<<<...<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<......>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>..<<<<.<<<..<<.<<<<..<<<...<<..<<<.<<..<<....>>...>>>>>...>>...>>>>>>>...>>>>><<<<<.........>>>>>....................<.<<<<.....>>>>.>..........>>>>...>>.>>>>>>>.....>>.>>>>>>>>>>>>>.>...........<<<<<........>>>>>..<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<..<<<<<<<...<<.<<<.<<<...<<<...........<<<<<..<<<......<<<<<<........>>>>>>...>>>.............>>>>>..>>>...>>>.>>>.>>...<<<..<<<<<.....>>>>>.>>>......>>>>>>>...>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>..........(((......>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>........<<<...<<<<<<...<<.......>>...>>>>>>....>>>..........<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>......>>>.>.....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<<....<<<..<<<<<<<...............>>>>>>><<<<<<...<<<<...<<<<.<<<<<<.)))>>>>>>...>>>>...>>>>.>>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>........>>>>>>>..................<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>.....>. (........((((.((((((....(((..(((((((((((((......(((((.....[[[..)).....((.(((...((.]]].....))......))).))...)))....(((....)))(.(((.((....)).))).)..(((((((...........)))))))..))....((((((.....(...[..)......))))).).........((....))...((((......(..]....).....))))...((((...(.(((......))).)......((((((.((.....((...(((((((.((..((...((((.(.....)))))[[......(((.....]])))...))....)).)))))))..))..)).))..)))))....((((..(((.[..).))..)))).......((((].[[[[))))...)))......)).))))))).))...............((....))....)).........((((....)))).............)....)))))).)))).....(.(.((..((((..[...))))..)).)...(.(........).).(((((.....(((((((.(((((....(....(((.....)))....)....((....))..(.((.....)).)....))))).)))))))..((.(...((((((.....(.(((..(((.((((....(((((......)))))....).)))...(((.((.((........)).)))))..).))..))).).(.((.......))...)..))))))......).))..((((((....(((((....)))))((((((((....((((((((((.....(((....(((.(((((...((((.().))).)...))))).)))..)).).....))))))))))...)))))).))..((((.((..(......)..)).))))....(((......)))....(((.(((...((([[[...(((((((.....(.....((..((.(((.(.(.....{.(((((.(.(..(((.........)))..).).....(...((......)).).)))))...).).))).)).))...........]]].)...))))))))))...)))))).(.(((((....))))).)....))))))(((((((..(((........(.(.((....))].)).....)))..))))).))......))))).......((...((((((.......))))))(..(....((....((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]]((((((((((.((...(((((...((((..(.((...((((((((.....{{...)))))....(((((..(((((.(((((.((.....))))))).)....))))..))))).....(..((.......))...)))).....)).)...))))(..)....)))))..))......)))))))))))))).))).....((......))...)).((((.....))))..)..)..((((....((((((((..(..(....(.......(((((....(.[..).....)))))((((((......))))))(...).......(.((((.((...((.........))...((((.((.....(((....))).......)).)))).]((((.(((..((.((((..((....((....(((...((....))....)).)...))....))))))...)))))(((((.........))))).........(..........(.(((.......))).)..).......))))...))..)))).).)..))..)))))))).))))))......).[..(((((......].)))))..(((.(((...((.((......((((.((((((..((((..(((((((((.((.(((.(((...((..(......[..(((((..(((.......((((..........))))....)))...........].))))))..))...))).))).))...(((..(((((.....))))).)))....)))))))))...))))..(((......[)))((((((..........]))))))(..(....(((((..(.(((((.........)))))...)....[.[[[.......)))))....((((..(((...{..)))..)))).(((....))).).]]].].....((((((..((..]]]]..)).)))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..((.(((.((......)).)))...)).(((((.....))))).....)))))..)...))..).....(((((((....))).))))....))..))..))).)))[...(((((((....(((..(.(((((.....(....)....))))).).(((((...((((...((((.((((((.}}.))))))...))))...)))).)))))...(((....((.(.....}.......).))....))).)))...]....)))))))(...(.......).....(((((((((.......)))))....((((((((..(.....(((((....)))))....)...))))).)))...))))...)..) 70S ribosome with P-site tRNA in chloramphenicol-treated Mycoplasma pneumoniae cells; 23S ribosomal RNA 7ph9 4 105 8.7 RF00001 URS000000E851_272634 36171285 0003735 0005840 272634 uuuggugcccaugucgcuguggaaacaccugguuccauuucgaacccagcaguuaagcacaguggagccgaauguagcugcagugagaauaggaaagcaccaagc .<<<<<<<.....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<.....<.<<....>>...>...>>...>>>>>>>.. (((((((.(....((.(((((.....((((((...(.....)...))))..))....)))))..)).((.......(......).......))...)))))))). 70S ribosome with P-site tRNA in chloramphenicol-treated Mycoplasma pneumoniae cells; 5S ribosomal RNA 7ph9 5 1493 8.7 RF00177,RF01959,RF01960 URS00019B76CF_272634 36171285 0003735 0005840 272634 ucugagaguuugauccuggcucaggauuaacgcuggcggcaugccuaauacaugcaagucgaucgaaaguaguaauacuuuagaggcgaacgggugaguaacacguauccaaucuaccuuauaaugggggauaacuaguugaaagacuagcuaauaccgcauaagaacuuugguucgaaucaaaguugaaaggaccugcaaggguucguuauuugaugagggugcgccauaucagcuaguuggugggguaacggccuaccaaggcaaugacguguagcuaugcugagaaguagaauagccacaaugggacugagacacggcccauacuccuacgggaggcagcaguagggaauuuuucacaaugagcgaaagcuugauggagcaaugccgcgugaacgaugaaggucuuuaagauuguaaaguucuuuuauuugggaagaaugacuuuagcagguaauggcuagaguuugacuguaccauuuugaauaagugacgacuaacuaugugccagcagucgcgguaauacauaggucgcaagcguuauccggauuuauugggcguaaagcaagcgcaggcggauugaaaagucugguguuaaaggcagcugcuuaacaguuguaugcauuggaaacuauuaaucuagagugugguagggaguuuuggaauuucauguggagcggugaaaugcguagauauaugaaggaacaccaguggcgaaggcgaaaacuuaggccauuacugacgcuuaggcuugaaaguguggggagcaaauaggauuagauacccuaguaguccacaccguaaacgauagauacuagcugucggggcgauccccucgguagugaaguuaacacauuaaguaucucgccuggguaguacauucgcaagaaugaaacucaaacggaauugacggggacccgcacaagugguggagcauguugcuuaauucgacgguacacgaaaaaccuuaccuagacuugacauccuuggcaaaguuauggaaacauaaugccgagugacagguggugcaugguugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuuaucguuaguuacauugucuagcgagacugcuaaugcaaauuggaggaaggaagggaugacgucaaaucaucaugccccuuaugucuagggcugcaaacgugcuacaauggccaauacaaacagucgccagcuuguaaaagugagcaaaucuguaaaguuggucucaguucggauugagggcugcaauucguccucaugaagucggaaucacuaguaaucgcgaaucagcuaugucgcggugaauacguucucgggucuuguacacaccgcccgucaaacuaugaaagcugguaauauuuaaaaacguguugcuaaccauuaggaagcgcaugucaaggauagcaccggugauuggaguuaagucguaacaagguaccccuacgagaacguggggguggauca .....<<<<..[.((([>.>>>.<<<..<<<<<..<<<<<<<<..<..<<...<...<<<..<<.<<<<<<....>>>>>>.>>>>>......<<........<<<.<<<..<<.......<<<<<.<<.....<<<<<......>>>>>......>>.>.....<<<<<<<........>>>>>>>....<<<<<<....>>>>>>>>>>......>>>>>.>>>.<<.....<<<...<<<<<<<.......>>>>>>>.>>>.......>>..<<<<<<<<....>>>...>>>>>.>>.<<<<<............>>>>>.<<<<....>>>>....>..>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<........<<.....>>.......>>>>...<<..<<<.........<<<<<<<........>>>>>>>..........>>>...>>.....<<<<<(((...<<<<<.....<..))).>.......>>>>>>>>>>..>>>>>.>>>..........<<<((.....<<<<...<<<.<<<<<<..<<<<<<<<<<.....<<<<<<<.....>>>>>>>..>>>>>>>>..>>.>>>>>>...<<<.<<<<...<<<<<<<....<<<<<<.<<..<<<......>>>.....>>.>>>>>.>..........<<....>>.>>>>>>>..>>>>..>>>...>>>...>>>>....<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<......>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<.......<<<....>>>.....>>>..].))).]<<<<<.<<<<<<<..<...<.<...<<<<<<<.........<<........>>..........<<<<<<<......<<<<.........<<<<....>>>>......>>.>>.<<<.<<....<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<...........>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>..>>>>>...>>>>>>>.......>>>>>>>.....<<<<<<......<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>...........<<<<<<<........>>>>>>>...........>.>.......<<<<<<..........>>>>>>.......>....>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<..<<<<.....<<<<<.<<<<..<<....>>.>>>>>>>>>....>>>>..>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>...... .....(((...[.[[[...))).(((...((((..(((((((((....(((.(((..(((..((.((((((....)))))).)))))......(((.......(((((((..((...(..((((.(.((.....((((((....))))))......)).).....(((((((........)))))))....(.(((......))).).))))..)..))))))))).(((....(((..(((((.((.......)).))))))))......)))..(((((.((....)).)...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(.(((....)))..))))).)).))))))..((((......(.((.....)).).....))))....(..(((...(....(.(.((((........)))).)..)...)....)))...)......(.((([[[...(((((.....((.]]])).......)))))))).)..))).).)))..........((([[...(.((((....((.((((((..(((((.(((......(((.(((.....))).)))...))).)))..)).))))))..(..(.((((....(((((((....(((((.(...((........))......).)))))....).......((....)).))))))...))))..)....)))....))))....((((((...((...((((.........))))...))))))))......{...((((((..(((.(((.((......)).))).)))...((..]])).....)))))))))).(((.......(((....))).....)))....]]].]((((..(((.(((..(..(((.(..((((.(((........((........))...........((((((..(...(.(((......((((((....))))))...)))..)).((.((....((.(((.(....((((((.((....))....(((......)))...)))))).....((.(.(((.(((.........))).)))..(..(((((....))))).....)..).)).....).).))....))..))))....)))))).......))).)))).(...((((((......(((..((..((((....))))..))....))).....))))))......(....(((((((........)))))))....)..)..).))).....(((((((.(.....)..)))))))......)....))).))).)).))..(.(..((.(.(.((.(((..((((((..(((......((.((..(((..((....)).))).)).)).....)))..))))))..))).)).)..).))...)..)..(((((.(((....))).)))))}..... 70S ribosome with P-site tRNA in chloramphenicol-treated Mycoplasma pneumoniae cells; 16S ribosomal RNA 7ph9 7 76 8.7 RF00005 URS000054164D_272634 36171285 0030533 0006412 272634 ggucuuguagcucagucgguagagcaacggucugaagaaccgugugucggcaguucgauucugcccgagaccacca <.<..<...<<<<........>>>>..<<<<.......>>>>......<<<<<.......>>>>>.>..>>..... (((((((..((((........))))..((((.......))))......(((((.......)))))))))))).... 70S ribosome with P-site tRNA in chloramphenicol-treated Mycoplasma pneumoniae cells; tRNA-Phe 7pha 3 2878 8.5 RF02540,RF02541 URS0000AB9B3C_272634 36171285 0003735 0005840 272634 aguuacuaagggcuuaugguggaugccuuggcacuaauaggcgaugaaggacguguuaaccugcgauaagcuucggguaggugguaagaaccucagauccggagauuuccgaauggagcaauccgguaguuggaaacagcuaucauuaauugaugaauaaauagucaauuaaagcaauacguggugaagugaaacaucucaguagccacaggaaaagaaaacgaaugugauuccguguguaguggcgagcgaaagcggaacaggccaaacuuaucauuagauagggguuguagggcuugcaauguggacuugaaaacgauagaagaagcuguuggaaagcagcgcgcaaaagggugauagccccguauuugaaauuguuuucauaccuagcgagaucccugaguagcucggaaaacguuauuuugagugaaucugcccagaccauuggguaagccuaaauacuaauuagugaccgauagcgaaacaguaccgugagggaaaggugaaaagaacccagagaugggagugaaauagauucugaaaccauaugccuacaacgugucagagcacauuaaugugugauggcgugcguuuugaaguaugagccggcgaguuaugauagcaagcguuaguuaaccaggagauggggagcuguagcgaaagcgaguuuuaaaagagcguuuguuuguuauuauagacccgaaacggguugagcuagucaugagcagguugaagguugaguaacaucaacuggaggaccgaaccgacucucguugaaacgauagcggaugacuugugauuaggggugaaauuccaaucgaaauccgugauagcugguucucgucgaaauagcuuuaaggcuagcgugagaucacaaauaaguggagguaaagcuacugaauguaugauggcgccggcguacugaauacaauuaaacucugaaugccauuuauuuuauucucgcagucagacagugggggauaagcuucauugucaagaggggaagagcccagaucauuaaauaagguccccaaaauauacuaaguggaaaaggaugugaaagugcuaaaacagcaaggauguuggcuuagaagcagccaucguuuaaagagugcguaacagcucacuugucgaguguuuuugcgccgaagauguaacggggcuaaguauauuaccgaauuuauggauaagauuuauaucuugugguagacgagcguuguauuggaguugaagucaaagcgugagcauugguggauccaauacaagugagaaugccggcaugaguaacgcuugggagugagaaucucccaaaccgauugacuaagguuuccuggaccagggucguccuuccaggguuagucuggaccuaagcugaggcugaaaagcguaggcgauggacaacagguuaauauuccuguacuuacaguuagacugauggagugacaaagaagguuuuccacccccauaauuggauuuggggauaaaucauaaggugguacaauaggcaaauccguugugcauaacauugagugaugaugucgagugaaaguagcgaaggugguauuaaucaugcuuucaagaaaagcuucuaggguuaaucuagcuguaaccaguaccgagaacgaacacacguagucaaggagaggauccuaagguuagcgagugaacuauagccaaggaacucugcaaauuaaccccguaaguuagcgagaaggggugcuuauguaaaaguaagccgcagugaagaacgaggggggacuguuuaacuaaaacacaacucuaugccaaaccguaaggugauguauauggggugacaccugcccagugcuggaagguuaaagaaggagguuagcgcaagcgaagcuuuuaacugaagccccagugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuagucggguaaauuccgucccgcuugaaugguguaaccaucucuugacugucucggcuauagacucggugaaauccagguacgggugaagacacccguuaggcgcaacgggacggaaagaccccgugaagcuuuacuguagcuuaauauugaucaggacauuaucauguagagaauagguaggagcaaucgaugcaaguucgcuaggacuuguugaugcgaaagguggaauacuacccuugguugugugcuguucuaauugguaacuguuauccaguuucaagacaguguuaggugggcaguuugacuggggcggucgccuccuaaaagguaacggaggcguacaaagguaccuucaguacgguuggaaaucguauguagaguguaaugguguaagggugcuugacugugagacauacaggucgaacaggugagaaaucaggucauagugauccggugguccaguauggaauggccaucgcucaacggauaaaagcuacuccggggauaacaggcugauacugcccaagaguucauaucgacggcaguguuuggcaccucgaugucgacucaucucauccucgagcugaagcagguucgaaggguucggcuguucgccgauuaaagagauacgugaguuggguucaaaccgucgugagacagguuggucccuaucuauugugcccguaggaagauugaagaguguugcuucuaguacgagaggaccgaagcgaggacaccucuuaugcuccaguuguagcgccagcugcaccgcuggguaguaacgugucuauuagauaaacgcugaaagcaucuaagugugaaacuaucucaaagauuaaucuucccauuucgcaagaaaguaagagccgucaaagacgaugacguugauagguuacagguguaagcauagugauauguugagcugaguaauacuaauugcucgaggacu .<<......<<<<.<<<<<<.....<<..<<<<<<<<<<<<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>.....>>>>>>>...>>>....<<<....>>><<<<<.<<....>>.>>>>>.<<<<<<<<<.........>>>>>>>>>.>>.....<<<<<.....<<....>>......>>>>>...........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<....<<<<<......>>>>>......<<<<<<<<<.....<....<<<<<<<<<<.<<<....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>...>..>>>>>..>>>>.....<<<<<<<<.......>>>>>>>>.......<<<<..<<<.>>>>...>>>......>>.>>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>.>>>>.......<<<<..<<<<......>>>>..>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<.....<<...<<<.....>>>...>>....<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<.<<........>>.>>>>>....>>>>>>>>>...<<.......>>......>>>>>>>.....>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<....<<<<<<<<<<.....<<<....<<...<<<......<<....>>.......>>>...>>..>>.>.....>>>>>>>>>>...>>>>>>..>..<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((....<<<<<<...........<<..<<<<<<...........<<<<<.<<...<<<.........>>>...>>.........<<......>>...>>>>>.......>>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>>..<<<<<....>>>>>......>>>>>><<<<<<<<<<<<......<<<<<.<<....>>.>>>>>...>>>>>>>>>>.>>.....>>>>>>.......<<...<<<<<<.......>>>>>>.<<.....<<.<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>....<<<<........>>>>.))<<<<<<<<<<<.....<<<<<...<<<<........<<<<<<<<<....(((...>>>>>....<<<<<...<<<..<<<<..<<.....>>.>>>>......>>>...>>>>>.......................>>>>...........>>>>........>>>>>.........>>>>>>>>>>>>>>>..>>.....<<......>>.>.>>.<<<<.....>>>>..>.>...<<<<<...<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<......>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<......>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<..<<<.<<..<<....>>...>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>......................<<<<.....>>>>............>>>>>..>>.>>>>>>>.....>>.>>>>>>>>>>>>>>>...........<<<<<........>>>>>..<<<<<<<..<<<.<<......<<<<.<<<<<<..<<<<..<<<<<<....<<.<<<.<<<...<<<...........<<<<<..<<........<<<<<<......>>>>>>.....>>.............>>>>>..>>>...>>>.>>>.>>...<<<..<<<<<.....>>>>>.>>>.......>>>>>>...>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>........[.(((......>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]......<<.<<<<.<<...>>>..>>>>>>.>>.............>>>>..>>>>>>........<<....<<<<<<...<.........>...>>>>>>.....>>.........<.<<<..<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>......>>>..>.....<<<<<<....>>>.>>>.....>>..>>>.>>>>>>>....<<<<<<<....<<<..<<<<<<<...............>>>>>>><<<<<<...<<<<...<<<<.<<<<<<.)))>>>>>>...>>>>...>>>>.>>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>........>>>>>>>..................<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>. (((.......(((.(((((.....(((..(((((((((((((......(((((.....[[[..)).....((.(((...(((]]]....)))......))).))...)))....(((....)))(.((((((....)))))).).(((((((((.........))))))))).))....((((((.....(...[..)......))))).).........((....))...((((......((.]...)).....))))...((((...(((((......)))))......(((((((((.....((...(((((((.((.(((...((((........))))[[......(((.....]])))...)))...)).)))))))..))..)))))..))))).....(((..(((....).))..)))........((((..[[.[))))...)))......)).))))))).))...............((....))....))......(..((((....))))............)).....))))).)))......(.(.((..((((..[...))))..)).).<.(.(........).).(.((((....(((((((.(((.(....(....(((.....)))....)....((....))..(.((.....)).)....).))).)))))))..((.(...((((((.....((((((.(((.(((.....(((((......)))))......)))...(((.((.((........)).)))))..).)).)))))).(.((.......))...)..))))))......).))..((((((....(((((....)))))(.(.((((....((((((((((.....(((....(((.(.((....(.((....))..)....)).).)))..)).).....))))))))))...)))).)..)..(((((((..(......)..)))))))....(((......)))....(((.(((...((([[[....(.((((.....(.....((..(..(((..((........((((.(.(..(((.........)))..).).....(...((......)).).))))....))..)))..).))...........]]].)...))))..))))...))))))...(((((....)))))......))))))(((((((..(((.......((.(.((....))].)))....)))..))))).)).....)))).).......((...((((((.......)))))).(......(((...(...(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))....((((........)))).]](((((((((((((...(((((...((((..(.....(((((((((.....{{...)))))((..(((((..(((((((((...((.....))..)))))....))))..)))))...))(..((.......))...))))).......)...))))(..)....)))))..)).....))))))))))))))).).).....((......))..))).((((.....)))).....)..((((....((((((((.((..(....(.......(((((....(.[..).....)))))(((((........)))))(...).......(.((((.((...((.........))...((((.((.....(((....))).......)).)))).]((((.(((..(((((((..((....((.....((...((....))....)).....))....)))))))..)))))(((((.........)))))........((..........(.(((.......))).)..)..)....))))...))..)))).).)..))).)))))))).))))))......).[..(((((.....>].)))))..(((.(((...((.((......((((.((((((..((((..((.(((.((.((.(((.((.....((.(......[..(((((..(((......((((((........))))))...)))...........].)))))).)).....)).))).))...(((..(((((.....))))).)))....)).))).))...))))..(((......[)))((((((..........]))))))(.((....(.(((..(.(((((.........)))))...)..(.[.[[[)......))).)....((((..(((...{..)))..)))).(((....))).))]]].].....((((((..((..].]]..)).)))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..((.((((((......))))))...)).(((((.....))))).....)))))..)...))..)......((((((....))).))).....))..))..))).)))[...(((((.(....(((..(((((((.....(....)....))))))).(((((...((((...((((.((((((.}}.))))))...))))...)))).)))))...(((....((.(.............).))....))).)))...]....).)))))(.................(((((((((.......)))))....(((.((((..(......((((....)))).....)...))))..)))...))))...)))) 70S ribosome with EF-Tu-tRNA and P-site tRNA in chloramphenicol-treated Mycoplasma pneumoniae cells; 23S ribosomal RNA 7pha 4 105 8.5 RF00001 URS000000E851_272634 36171285 0003735 0005840 272634 uuuggugcccaugucgcuguggaaacaccugguuccauuucgaacccagcaguuaagcacaguggagccgaauguagcugcagugagaauaggaaagcaccaagc <<<<<<<<.....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<.......<<<..>>>.......>>...>>>>>>>>. (.((((((.....((.(((((.....((((((...(.....)...))))..))....)))))..)).((.......(......).......))...))))).)). 70S ribosome with EF-Tu-tRNA and P-site tRNA in chloramphenicol-treated Mycoplasma pneumoniae cells; 5S ribosomal RNA 7pha 5 1493 8.5 RF00177,RF01959,RF01960 URS00019B76CF_272634 36171285 0003735 0005840 272634 ucugagaguuugauccuggcucaggauuaacgcuggcggcaugccuaauacaugcaagucgaucgaaaguaguaauacuuuagaggcgaacgggugaguaacacguauccaaucuaccuuauaaugggggauaacuaguugaaagacuagcuaauaccgcauaagaacuuugguucgaaucaaaguugaaaggaccugcaaggguucguuauuugaugagggugcgccauaucagcuaguuggugggguaacggccuaccaaggcaaugacguguagcuaugcugagaaguagaauagccacaaugggacugagacacggcccauacuccuacgggaggcagcaguagggaauuuuucacaaugagcgaaagcuugauggagcaaugccgcgugaacgaugaaggucuuuaagauuguaaaguucuuuuauuugggaagaaugacuuuagcagguaauggcuagaguuugacuguaccauuuugaauaagugacgacuaacuaugugccagcagucgcgguaauacauaggucgcaagcguuauccggauuuauugggcguaaagcaagcgcaggcggauugaaaagucugguguuaaaggcagcugcuuaacaguuguaugcauuggaaacuauuaaucuagagugugguagggaguuuuggaauuucauguggagcggugaaaugcguagauauaugaaggaacaccaguggcgaaggcgaaaacuuaggccauuacugacgcuuaggcuugaaaguguggggagcaaauaggauuagauacccuaguaguccacaccguaaacgauagauacuagcugucggggcgauccccucgguagugaaguuaacacauuaaguaucucgccuggguaguacauucgcaagaaugaaacucaaacggaauugacggggacccgcacaagugguggagcauguugcuuaauucgacgguacacgaaaaaccuuaccuagacuugacauccuuggcaaaguuauggaaacauaaugccgagugacagguggugcaugguugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuuaucguuaguuacauugucuagcgagacugcuaaugcaaauuggaggaaggaagggaugacgucaaaucaucaugccccuuaugucuagggcugcaaacgugcuacaauggccaauacaaacagucgccagcuuguaaaagugagcaaaucuguaaaguuggucucaguucggauugagggcugcaauucguccucaugaagucggaaucacuaguaaucgcgaaucagcuaugucgcggugaauacguucucgggucuuguacacaccgcccgucaaacuaugaaagcugguaauauuuaaaaacguguugcuaaccauuaggaagcgcaugucaaggauagcaccggugauuggaguuaagucguaacaagguaccccuacgagaacguggggguggauca .....<<<<..[.(((..>>>>.<<<<.<<<<...<<<<<<<<.....<<<.<<...<<<..<<.<<<<<<....>>>>>>.>>>>>......<<........<<<.<<<..<<.......<.<<<.<<.....<<<<<......>>>>>......>>.>.....<<<<<<<<......>>>>>>>>....<<<<<<....>>>>>>>>.>......>>>>>.>>>.<......<<<...<<<<<<<.......>>>>>>>.>>>........>..<<<<<<<<....>>>...>>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>....>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<.......<<<.....>>>......>>>>...<...<<<.......<<<<<<<<<........>>>>>>>>>........>>>....>.....<<<<<(((...<<<<<.....<..))).>.......>>>>>>>>>>...>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<..<<<<<<<<<<.....<<<<<<<.....>>>>>>>..>>>>>>>>..>>.>>>>>>...<<<<<<<.....<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>....>>>>.>>>...>>>...>>>>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<......>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<.......<<<....>>>.....>>>....))).]<<<<<.<<<<<<<..<..<<<<...<<<<<<<<........<<........>>..........<<<<<<<......<.<<........<<<<<....>>>>>.....>>.>..<<<.<<....<<<<<.<.....<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<...........>>>>>>.....<<<<<....>>>>>........>>>>.....>...>>>...>>..>>>>>...>>>>>>>......>>>>>>>>......<<<<<......<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>.......<....<<<<<<<........>>>>>>>....>......>>>>......<<<<<<..........>>>>>>.......>....>>>>>>>>>>.>>....<..<<.<.<<<<..<<..<<<<<<..<<<<......<<<<<.<<<..<<....>>.>>>>>>>>.....>>>>..>>>>>>..>>..>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .....((((..[.[[[..)))).((((.((((...(((((((((....(...(((..(.(..((.((((((....)))))).))).)......(((.......(((((((..((........((((.((.....(((((......)))))......)).).....(((((((........)))))))....((((((....))))))))).......))))))))).(......((...(((((.((.......)).))))).))........)..((((((((....))))...))))))).(((((............))))).((((....))))...)))..).).....(..((...(((((....)))).))).).)).))))))..((((......((((.....)))).....))))....(..(((...(...(..(.((((........)))).)..)...)....)))...)........((([[[...(((((.....((.]]])).......)))))))).....))))))))..........((([[...(.((((....((.((((.(..((((...((......(((((((.....)))))))...))...))..)).).))))..((((..(((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))...)))..)))....))))....((((((...((...((((.........))))...))))))))......{...((((.(..(((((((.((......)).)))))))...((..]])).....).)))))))).(.(.......(((....))).....).)....]]].](((((.(((((((.((..((((...(((.((((((......((........))..........(((((....(.....(((((....((((((....)))))).)))))...).((.((....((.(((.(....((((((.((....))....(((......)))...)))))).....((.(.(((.(((.........))).)))..(..(.(((....))).).....)..).)).....).).))....))..))))......)))))...)).)))).))).(...((((((......(((..(((..(((....))).).))....))).....))))))......(....(((((((........)))))))....)..)...)))).....(.(((((..........))))).)......))...)))))))))).))..(.(..((.(..(((..((...(((((..(((.(.....((((..(((..((....)).))).))))....).)))..)))))...))..)).)..).))...)..)..(((((.(((....))).)))))}..... 70S ribosome with EF-Tu-tRNA and P-site tRNA in chloramphenicol-treated Mycoplasma pneumoniae cells; 16S ribosomal RNA 7pha 6 76 8.5 RF00005 URS000054164D_272634 36171285 0030533 0006412 272634 ggucuuguagcucagucgguagagcaacggucugaagaaccgugugucggcaguucgauucugcccgagaccacca <<<<.<<..<<<<........>>>>...<<<.......>>>.......<<<<<.......>>>>>>>.>>>>.... ((((..(..((.((.....).).))...(((.......))).......(.(((.......))).))..)))).... 70S ribosome with EF-Tu-tRNA and P-site tRNA in chloramphenicol-treated Mycoplasma pneumoniae cells; tRNA-Phe 7pha 7 76 8.5 RF00005 URS000054164D_272634 36171285 0030533 0006412 272634 ggucuuguagcucagucgguagagcaacggucugaagaaccgugugucggcaguucgauucugcccgagaccacca <<<<<<....<<<........>>>...<<<.........>>>......<<<<.........>>>>.>>>>>>.... .(..(((....((........))....((((.......))))......(((((.......))))))))...).... 70S ribosome with EF-Tu-tRNA and P-site tRNA in chloramphenicol-treated Mycoplasma pneumoniae cells; tRNA-Phe 7phb 3 2878 4.9 RF02540,RF02541 URS0000AB9B3C_272634 36171285 0003735 0005840 272634 aguuacuaagggcuuaugguggaugccuuggcacuaauaggcgaugaaggacguguuaaccugcgauaagcuucggguaggugguaagaaccucagauccggagauuuccgaauggagcaauccgguaguuggaaacagcuaucauuaauugaugaauaaauagucaauuaaagcaauacguggugaagugaaacaucucaguagccacaggaaaagaaaacgaaugugauuccguguguaguggcgagcgaaagcggaacaggccaaacuuaucauuagauagggguuguagggcuugcaauguggacuugaaaacgauagaagaagcuguuggaaagcagcgcgcaaaagggugauagccccguauuugaaauuguuuucauaccuagcgagaucccugaguagcucggaaaacguuauuuugagugaaucugcccagaccauuggguaagccuaaauacuaauuagugaccgauagcgaaacaguaccgugagggaaaggugaaaagaacccagagaugggagugaaauagauucugaaaccauaugccuacaacgugucagagcacauuaaugugugauggcgugcguuuugaaguaugagccggcgaguuaugauagcaagcguuaguuaaccaggagauggggagcuguagcgaaagcgaguuuuaaaagagcguuuguuuguuauuauagacccgaaacggguugagcuagucaugagcagguugaagguugaguaacaucaacuggaggaccgaaccgacucucguugaaacgauagcggaugacuugugauuaggggugaaauuccaaucgaaauccgugauagcugguucucgucgaaauagcuuuaaggcuagcgugagaucacaaauaaguggagguaaagcuacugaauguaugauggcgccggcguacugaauacaauuaaacucugaaugccauuuauuuuauucucgcagucagacagugggggauaagcuucauugucaagaggggaagagcccagaucauuaaauaagguccccaaaauauacuaaguggaaaaggaugugaaagugcuaaaacagcaaggauguuggcuuagaagcagccaucguuuaaagagugcguaacagcucacuugucgaguguuuuugcgccgaagauguaacggggcuaaguauauuaccgaauuuauggauaagauuuauaucuugugguagacgagcguuguauuggaguugaagucaaagcgugagcauugguggauccaauacaagugagaaugccggcaugaguaacgcuugggagugagaaucucccaaaccgauugacuaagguuuccuggaccagggucguccuuccaggguuagucuggaccuaagcugaggcugaaaagcguaggcgauggacaacagguuaauauuccuguacuuacaguuagacugauggagugacaaagaagguuuuccacccccauaauuggauuuggggauaaaucauaaggugguacaauaggcaaauccguugugcauaacauugagugaugaugucgagugaaaguagcgaaggugguauuaaucaugcuuucaagaaaagcuucuaggguuaaucuagcuguaaccaguaccgagaacgaacacacguagucaaggagaggauccuaagguuagcgagugaacuauagccaaggaacucugcaaauuaaccccguaaguuagcgagaaggggugcuuauguaaaaguaagccgcagugaagaacgaggggggacuguuuaacuaaaacacaacucuaugccaaaccguaaggugauguauauggggugacaccugcccagugcuggaagguuaaagaaggagguuagcgcaagcgaagcuuuuaacugaagccccagugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuagucggguaaauuccgucccgcuugaaugguguaaccaucucuugacugucucggcuauagacucggugaaauccagguacgggugaagacacccguuaggcgcaacgggacggaaagaccccgugaagcuuuacuguagcuuaauauugaucaggacauuaucauguagagaauagguaggagcaaucgaugcaaguucgcuaggacuuguugaugcgaaagguggaauacuacccuugguugugugcuguucuaauugguaacuguuauccaguuucaagacaguguuaggugggcaguuugacuggggcggucgccuccuaaaagguaacggaggcguacaaagguaccuucaguacgguuggaaaucguauguagaguguaaugguguaagggugcuugacugugagacauacaggucgaacaggugagaaaucaggucauagugauccggugguccaguauggaauggccaucgcucaacggauaaaagcuacuccggggauaacaggcugauacugcccaagaguucauaucgacggcaguguuuggcaccucgaugucgacucaucucauccucgagcugaagcagguucgaaggguucggcuguucgccgauuaaagagauacgugaguuggguucaaaccgucgugagacagguuggucccuaucuauugugcccguaggaagauugaagaguguugcuucuaguacgagaggaccgaagcgaggacaccucuuaugcuccaguuguagcgccagcugcaccgcuggguaguaacgugucuauuagauaaacgcugaaagcaucuaagugugaaacuaucucaaagauuaaucuucccauuucgcaagaaaguaagagccgucaaagacgaugacguugauagguuacagguguaagcauagugauauguugagcugaguaauacuaauugcucgaggacu .<<......<<<<.<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<.))).....>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>....<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...(((....<<<<<......>>>>>......<<<<<<<<<..........<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>......>>>>>..>>>>.....<<<<<<<<<....>.>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<....>>>>.............}....>>>>>>.>>>>.......<<<<..<<<<......>>>>..>>>>...<<..........>>.<<<<<<....<<<<<<<<<<<<....<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<.<<........>>.>>>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<....<<<<<<<<<<.......<....<<..<<<<<...<<<<<..>>>>.>...>>>>>..>>..>........>>>>>>>>>>...>>>>>>.>>..<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((...<<<<<<<...........<<..<<<<<<<.<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>.>>>>>>>.>>...........))).....>>>>>>>>>>...>>>>>>><<<<<<<....>>>>>>>....>>>>>><<<<<<<<<<<<......<<<<<.<<....>>.>>>>>...>>>>>>>>>>.>>.....>>>>>>.......<<...<<<<<<.......>>>>>>.<<<....<<<<<.<<<..<<<<<<...<<.....>>.>>>>>>....((<<<<.<.<..<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<.<...<<<<<....<<<...<<<..<<<<<<<<<....(((...>>>>><<..<<<<<..<<<<<<<<<<<.<<.....>>>>>>>>>....>>>>..>>>>>...>><..<<.......>>...>>>>>....>>>.....>>>........>>>>.>.>......>>>>>>>>>>>>>>>.>>>.....<<......>>>>>>>.<<<<.....>>>>..>>>...<<<<<...<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<......>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<..<<..<<<<<<<.<<....>>..>>>>>>>..>>..>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<.<<<.......>>>.>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>>>>>>>>...........<<<<<........>>>>>..<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<<.<<.<<<.<<<<.<<<<...........<<<<...<<<......<<<<<<<......>>>>>>>...>>>..............>>>>..>>>>.>>>>.>>>.>>...<<<..<<<<<.....>>>>>.>>>....>>>>>>>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>......<...(((>.....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<<....<<<..<<<<<<<...............>>>>>>><<<<<<...<<<<...<<<<<<<<<<<.)))>>>>>>..>>>>>...>>>>.>>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>........>>>>>>>..................<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>. .(.......((((.(((((.....(((..(((((((((((((......((((((....[[[.))).....((((((...((.]]].....))......))))))...)))....(((....)))(((((.((....)).))))).(((((((((.........))))))))).))....((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...(.(((......))).)......((((((.((......(...((((((((((..((...(((((......)))))[[......(((.....]])))...))....))))))))))...)..)).))..)))))....(((((((((.[..).))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((....))))............)).....))))).)))).....(.((((..((....[.....))..)))).<.(............).((((((....(((((((((((.(....(....(((.....)))....)....((....))..((((.....))))....).)))))))))))..((.(...((((((.....((((((.(((.((((...((((((......))))))...)<)))...(((.((.((........)).)))))..).)).)))))).(.((.......))...)..))))))......).))..(((((.....(((((....)))))(((((.(.....((((((((((.....(((....(((.((((....((((....))).)....)))).)))..)).).....))))))))))....).))).))..(((((((.((......)).)))))))....(((......)))...((((.(((...((([[[...(((((((.....(.....((..((((((...(.......(((((.(((...((.........).)..))).....(...((......)).).)))))...)...)))))).))...........]]].)...))))))))))...)))))))..((((......)))).......)))))(.(((((..(((......(.(.(.((....))]).).)...)))..)))))..).....)))))).......((...((((((.......))))))(.((....(.....((...((((((...((.....)).))))))....((...[.((...(((...(((....)))...)))...))...(((((........)))))))(((((..((((.(...((((....(.(...((((...((((((((.....{{...)))))((..(((((..((((((((((..((.....)).))))))....))))..)))))...))...((.......))....))).....)))).....))(..).....))))..)......))))..)))))].....)).....((......))....).((((.....))))..)).)..((((....((((((((.((..(............(((((....(.[..).....)))))((((((......))))))(...).......(((((((((.>.((.........))...(((((((.....(((....))).......))))))).]((((.(((..(((((((..(((...((..(((.((..((....))...)).)))..))...))))))))..)))))(((((.........)))))........((..........(.(((.......))).)..)..)....))))...)).)))))))....))).)))))))).))))))......).[..(((((.....>].)))))..((((((....((.((......((((.((((((..(((((..(((((((..(..(((.(((..((((.([........(((....((.......((.((..(...].).)).))....))...............)))).))))..))).)))..)...(((..(((((.....))))).))).....)))))))...)))))..(((......[)))((((((..........]))))))(.((...((.((((.(..((((.........))))....)......[[[......)))).))...((((..(((...{..)))..)))).(((....))).))]]].......(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......(.((.((((((..((.((((((......))))))...)).(((((.....))))).....)))))..)...))..).....(((((((....))).))))....))..))...))))))[...(((((((....(((..(((((((.....(....)....))))))).(((((...(((....(((((((((((.}}.))))))..)))))....))).)))))....((....((((.............))))....))..)))...]....)))))))(...(.......).....(((((((((.......)))))....((((((((.(((.....((((....))))....)))..))))).)))...))))...).). 70S ribosome with A- and P-site tRNAs in chloramphenicol-treated Mycoplasma pneumoniae cells; 23S ribosomal RNA 7phb 4 105 4.9 RF00001 URS000000E851_272634 36171285 0003735 0005840 272634 uuuggugcccaugucgcuguggaaacaccugguuccauuucgaacccagcaguuaagcacaguggagccgaauguagcugcagugagaauaggaaagcaccaagc <<<<<<<<.....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<..<....<<<..>>>.....>.>>...>>>>>>>>. .((((((......((((((((......(((((...(.....)...))))..).....)))))).))..(......................).....)))))).. 70S ribosome with A- and P-site tRNAs in chloramphenicol-treated Mycoplasma pneumoniae cells; 5S ribosomal RNA 7phb 5 1493 4.9 RF00177,RF01959,RF01960 URS00019B76CF_272634 36171285 0003735 0005840 272634 ucugagaguuugauccuggcucaggauuaacgcuggcggcaugccuaauacaugcaagucgaucgaaaguaguaauacuuuagaggcgaacgggugaguaacacguauccaaucuaccuuauaaugggggauaacuaguugaaagacuagcuaauaccgcauaagaacuuugguucgaaucaaaguugaaaggaccugcaaggguucguuauuugaugagggugcgccauaucagcuaguuggugggguaacggccuaccaaggcaaugacguguagcuaugcugagaaguagaauagccacaaugggacugagacacggcccauacuccuacgggaggcagcaguagggaauuuuucacaaugagcgaaagcuugauggagcaaugccgcgugaacgaugaaggucuuuaagauuguaaaguucuuuuauuugggaagaaugacuuuagcagguaauggcuagaguuugacuguaccauuuugaauaagugacgacuaacuaugugccagcagucgcgguaauacauaggucgcaagcguuauccggauuuauugggcguaaagcaagcgcaggcggauugaaaagucugguguuaaaggcagcugcuuaacaguuguaugcauuggaaacuauuaaucuagagugugguagggaguuuuggaauuucauguggagcggugaaaugcguagauauaugaaggaacaccaguggcgaaggcgaaaacuuaggccauuacugacgcuuaggcuugaaaguguggggagcaaauaggauuagauacccuaguaguccacaccguaaacgauagauacuagcugucggggcgauccccucgguagugaaguuaacacauuaaguaucucgccuggguaguacauucgcaagaaugaaacucaaacggaauugacggggacccgcacaagugguggagcauguugcuuaauucgacgguacacgaaaaaccuuaccuagacuugacauccuuggcaaaguuauggaaacauaaugccgagugacagguggugcaugguugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuuaucguuaguuacauugucuagcgagacugcuaaugcaaauuggaggaaggaagggaugacgucaaaucaucaugccccuuaugucuagggcugcaaacgugcuacaauggccaauacaaacagucgccagcuuguaaaagugagcaaaucuguaaaguuggucucaguucggauugagggcugcaauucguccucaugaagucggaaucacuaguaaucgcgaaucagcuaugucgcggugaauacguucucgggucuuguacacaccgcccgucaaacuaugaaagcugguaauauuuaaaaacguguugcuaaccauuaggaagcgcaugucaaggauagcaccggugauuggaguuaagucguaacaagguaccccuacgagaacguggggguggauca .....<<<<..[.(((..>>>>.<<<<.<<<<...<<<<<<<<.....<<<.<<<..<<<..<<.<<<<<<....>>>>>>.>>>>>......<<........<<<<<<<..<<...<..<<<<.<.<<.....<<<<<<....>>>>>>......>>.>.....<<<<<<<<<<..>>>>>>>>>>....<<<<<<....>>>>>>.>>>>..>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>...>>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>......<<.<<<....<<<<....>>>>..>>>>>>>.>>>>>>..<<<<.......<<<<...>>>>......>>>>.......<<<.......<<<<<<<<<........>>>>>>>>>........>>>..........<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>...>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<..<<<<<<<<<<.....<<<<<<<.....>>>>>>>..>>>>>>>>..>>.>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<<..<<<......>>>.....>>>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<......>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<<....<<<<<....>>>>>..>>>>....))).]<<.<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<.<.......<<<<<<....>>>>>>....>..>>.<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<.........>>>>>>>.....<<<<<....>>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>....>>>>>>>......<..<.<<<<<<<........>>>>>>>>...>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>..>>....<..<<.<.<<<<.<<<..<<<<<<..<<<<<....<<<<<.<<<<..<<....>>.>>>>>>>>>...>>>>>..>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .....((((..[.[[[..))))..(((.((.....((((((((.....(...(((..(((..((.((((((....)))))).)))))......(((.......(((..((..((...(.......(.((.....((((((....))))))......)).).....(.(((((...()...))))).)....(.((((....)))).).......)..))))..))).(((....(((..((((((((.......)))))))))))......)))..(((((.((....)).)...))))))).(((((............))))).((((....))))...)))..).......(..((...(((((....)))).))).).)).))))))..((((......((((.....)))).....))))....(..(((...(....(((.((((........)))).)))....)....)))...)......((((([[[...(((((.....((.]]])).......)))))))))).....)))))...........((([[...(.((((...(((.((((((..(((((.(((.......((((((.....))))))....))).)))..)).))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((..(((((......)))))..)))...((..]])).....)))))))))).(((.......(((....))).....)))....]]].](.(((.(((((((.....((......(((((((........((........))..........(((.(....(...((..(......((((.(....).))))....)..))).((.(((....(((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((.(((.........))).)))..(..(((((....))))).....)..)))).....).).)))...)..))))).......))))......)))))))..(...((((((......(((..(((.((((....))))).))....))).....))))))......(....((((.((........).)))))....)..).....)).....(((((((..........)))))))...........))))))))))..)..(.(..((.(.((((..((..((((((...((((....(((.(..(((..((....)).))).).)))...))))...))))))..))..))))..).))...)..)..(((((((((....)))))))))}..... 70S ribosome with A- and P-site tRNAs in chloramphenicol-treated Mycoplasma pneumoniae cells; 16S ribosomal RNA 7phb 6 76 4.9 RF00005 URS000054164D_272634 36171285 0030533 0006412 272634 ggucuuguagcucagucgguagagcaacggucugaagaaccgugugucggcaguucgauucugcccgagaccacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((........)))).(((((.......))))).....(((((.......)))))))))))).... 70S ribosome with A- and P-site tRNAs in chloramphenicol-treated Mycoplasma pneumoniae cells; tRNA-Phe 7phb 7 76 4.9 RF00005 URS000054164D_272634 36171285 0030533 0006412 272634 ggucuuguagcucagucgguagagcaacggucugaagaaccgugugucggcaguucgauucugcccgagaccacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((........)))).(((((.......))))).....(((((.......)))))))))))).... 70S ribosome with A- and P-site tRNAs in chloramphenicol-treated Mycoplasma pneumoniae cells; tRNA-Phe 7phc 3 2878 9.9 RF02540,RF02541 URS0000AB9B3C_272634 36171285 0003735 0005840 272634 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((.(......(((..(((((.....((..(((((((((((((......(((((.....[[[..)).....((.(((...((.]]].....))......))).))...)))....(((....)))(..(((((....)))))..)..((.(((((.........))))).))..))....((((((.....(...[..)......)))))..)........((....))...((((......(..]....).....))))...((((...(.(((......))).)......((((((.((.....(....(((((((.((..((...((((........))))[[......(((.....]])))...))....).))))))))...)..)).))..))))).....(((..(((.[..).))..)))........((((].[[[[))))...)))......)).))))))).))...............((....))....)).........((((....))))..................)))))..)))......(.(.((...(((..[...)))...)).)...(((........)))...(.((....(((((((.(((.(....(....(((.....)))....)....((....))..((((.....))))....).))).)))))))..((.(...(((.((.....(..((.((((.((((....(((((......)))))....)<)))...(((.((.((........)).)))))..).))).))..).(.((.......))...)..)).)))......).))..(((.((....((((......))))((..((((.....((.((((.(......((....(.(.(((((...(.(.(..).)..)...))))).).)..)).......).))))..))...))))...))..(((((((..(......)..))))))).....((......).)....(((.(.(...((([[[...(((((((.....(.....((..(..(((....(......(((((.(.(..(((.........)))..).).....(...((......)).).)))))...)...)))..).))...........]]].)...))))))))))....))))).(.(((((....))))).)....)).)))(.((((((.(((.......((((.((....))]))))....))).))))))..).....)).)..............((((((.......)))))).(.(.....((...((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...)).....(((........)))..]](((((((((((((...((((.....(((.....(...(.((((((.....{{...)))))((..(((((..((((((((((..((.....)).))))))....))))..)))))...))(..(.........)...)).).....)......))).(..).....))))..)).....))))))))))))))).))).....((......))..))..((((.....))))...).)..((((....((((((((.((..(....(.......(((((....(.[..).....)))))((((((......))))))(...).......(.((.(.((.>.((.........))...(((((((.....(((....))).......))))))).]((((.(((..((.((((..((....((..(.(((...((....))....))).)..))....))))))...)))))(.(((.........))).).........(..........(.(((.......))).)..).......))))...))..).)).).)..))).)))))))).))))........).[..(((((......].)))))..(((((((...((.((......((((.((((((..((((...(((((((..((.(((.(((..((((.(......[..((.((..(((.......((((((......))))))....)))...........].)).))).))).).))).))).))...(((..(((((.....))))).))).....)))))))....))))..(((......[)))((((((..........]))))))(.((...((.((((.(..((((.........))))....)....[.[[[......)))).))...((((..(((...{..)))..)))).(((....))).))]]].].....((.(((..((..]]]]..)).))).)).....)}......))))..)))))).......((((.(.((((((...((.......))...))))))...)))).)........(.((.((((((..((.(((.(........).)))...)).(((((.....))))).....)))))..)...))..).....(((((((....))).))))....))..))..)))))))[...(((((((....(((..(((((((.....(....)....))))))).(((((...(((....((((.((.(((.}}.))).))...))))....))).)))))...(((.....(.(.............).).....))).)))...]....)))))))(.................(((((((((.......)))))....(((.((((..(......((((....)))).....)...))))..)))...))))...)))) 70S ribosome with A*- and P/E-site tRNAs in chloramphenicol-treated Mycoplasma pneumoniae cells; 23S ribosomal RNA 7phc 4 105 9.9 RF00001 URS000000E851_272634 36171285 0003735 0005840 272634 uuuggugcccaugucgcuguggaaacaccugguuccauuucgaacccagcaguuaagcacaguggagccgaauguagcugcagugagaauaggaaagcaccaagc <<<<<.<<.....<<<<<<<<.....<<<<<<.............>>>>..>>....>>>>>>.>>.<<.......<<....>>.......>>...>>.>>>>>. .((..........((((((((.....((.(((...(.....)...)))...))....)))))).)).((.......(......).......))........)).. 70S ribosome with A*- and P/E-site tRNAs in chloramphenicol-treated Mycoplasma pneumoniae cells; 5S ribosomal RNA 7phc 5 1493 9.9 RF00177,RF01959,RF01960 URS00019B76CF_272634 36171285 0003735 0005840 272634 ucugagaguuugauccuggcucaggauuaacgcuggcggcaugccuaauacaugcaagucgaucgaaaguaguaauacuuuagaggcgaacgggugaguaacacguauccaaucuaccuuauaaugggggauaacuaguugaaagacuagcuaauaccgcauaagaacuuugguucgaaucaaaguugaaaggaccugcaaggguucguuauuugaugagggugcgccauaucagcuaguuggugggguaacggccuaccaaggcaaugacguguagcuaugcugagaaguagaauagccacaaugggacugagacacggcccauacuccuacgggaggcagcaguagggaauuuuucacaaugagcgaaagcuugauggagcaaugccgcgugaacgaugaaggucuuuaagauuguaaaguucuuuuauuugggaagaaugacuuuagcagguaauggcuagaguuugacuguaccauuuugaauaagugacgacuaacuaugugccagcagucgcgguaauacauaggucgcaagcguuauccggauuuauugggcguaaagcaagcgcaggcggauugaaaagucugguguuaaaggcagcugcuuaacaguuguaugcauuggaaacuauuaaucuagagugugguagggaguuuuggaauuucauguggagcggugaaaugcguagauauaugaaggaacaccaguggcgaaggcgaaaacuuaggccauuacugacgcuuaggcuugaaaguguggggagcaaauaggauuagauacccuaguaguccacaccguaaacgauagauacuagcugucggggcgauccccucgguagugaaguuaacacauuaaguaucucgccuggguaguacauucgcaagaaugaaacucaaacggaauugacggggacccgcacaagugguggagcauguugcuuaauucgacgguacacgaaaaaccuuaccuagacuugacauccuuggcaaaguuauggaaacauaaugccgagugacagguggugcaugguugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuuaucguuaguuacauugucuagcgagacugcuaaugcaaauuggaggaaggaagggaugacgucaaaucaucaugccccuuaugucuagggcugcaaacgugcuacaauggccaauacaaacagucgccagcuuguaaaagugagcaaaucuguaaaguuggucucaguucggauugagggcugcaauucguccucaugaagucggaaucacuaguaaucgcgaaucagcuaugucgcggugaauacguucucgggucuuguacacaccgcccgucaaacuaugaaagcugguaauauuuaaaaacguguugcuaaccauuaggaagcgcaugucaaggauagcaccggugauuggaguuaagucguaacaagguaccccuacgagaacguggggguggauca .....<<<<..[.(((..>>>>.<<<<.<<<<....<<.<<<<..<..<<..<<<..<<<..<<.<<<<<<....>>>>>>.>>>>>......<<..........<.<<<..<<......<<<<<<.<<.....<<<<<<....>>>>>>......>>.>.....<<<<<<..<<.>>...>>>>>>....<<<<<<....>>>>>>>>>>>.....>>>>>.>...<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>...>>>>>.>>.<<<<<............>>>>>.<<<<....>>>>...>>>.>>>.....<..<<<...<<<<<....>>>>.>>>>.>>>.>>.>>...<<<<.......<<<.....>>>......>>>>...<....<<.......<<<<<<<<<........>>>>>>>>>........>>.....>.....<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>...>>>>>>>>..........<<<((.....<<<<....<<.<<<<<<..<<<<<.<<<<.....<<<<<<<.....>>>>>>>..>>>>.>>>..>>.>>>>>>...<<<.<<<<...<<<<<<<....<<<<<<<<<..<<........>>.....>>>>>>>>>...........<<....>>.>>>>>>>..>>>>..>>>...>>....>>>>....<<<<<<....<...<<<<.........>>>>...>.>>>>>>..........<<<<.<..<<<<<<<<<<......>>>>>>>>>>...<<..))>>.....>.>>>>.>>>.<<<......<<<<....>>>>....>>>....))).]<<<<<.<<<<<<<.<<..<<<<...<<<<<<<<<<......<<........>>..........<<<<<<.........<..<.....<<<<<<....>>>>>>..>..>.....<<.<<<...<<<<<<.<....<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<.<..........>>>>>>......<<........>>.........>>>>.....>.>.>>>...>>.>>>>>.....>>>>>>...>>.>>>>>>>>.....<<<<<<......<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>...........<<<<<<<........>>>>>>>...........>>>>.....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<...<<<<<<..<<<<.....<<<<<<.<<<..<<....>>.>>>>>>>>>....>>>>..>>>>>>...>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>...... .....(((...[.[[[...))).((((.((...(...(.(((((....(...(....(((..((.((((((....)))))).))))).......(........(...(((..((...(...(((((.((.....((((((....))))))......)).).....(.((.((........).))).)....(..(((....)))..)))))...)..)))))...).((.....(((..(((((.((.......)).)))))))).......))..((((((((....))))...)))).)..(((((............))))).((((....))).)....)..).).....(..((....((((....))))..)).).)).)).)....((((........((.....)).......))))....(..(((...(...(((((((((........))))))).))..)....)))...)......((((([[[...(((((.....((.]]])).......))))))))))..)..))))))..........((([[...(.((((....((.((((.(..(((((..(((......((((((.....))))))...)))..)).).)).).))))..((((.(((....((((((((...((((((((...((........))......))))))))...).......((....)).)))))))...)))..)))..)))....))))....(((.((........((((.........)))).....)).)))......{...((((((..(((.((((((......)))))).)))...((..]])).....)))))))))).(((.......(((....))).....)))....]]].](((((.(((.(((.....(((....((((.(.(........((........))..........(((.(....(...(...(((.....((..(....)..))..)))...).).((.((....((((((.(....(((((((((....)))...(((......)))...)))))).....((.(.((((.(...........).))))..(..(..((....).).).....)..).)).....).).)))...))..))))......).)))......).).)))).(...(.((((......(.(..((..((((....))))..))....).).....)))).)......(....(((((((........)))))))....)..)....))).....(.(((((..........))))).)...........))).)))))).))..(.(...(.(.(.((.(.(..((.(((..((((.....((.(((.(((..((....)).)))))).))....))))..))).))..).).)).)..).)....)..)..(((((((((....)))))))))}..... 70S ribosome with A*- and P/E-site tRNAs in chloramphenicol-treated Mycoplasma pneumoniae cells; 16S ribosomal RNA 7phc 6 76 9.9 RF00005 URS000054164D_272634 36171285 0030533 0006412 272634 ggucuuguagcucagucgguagagcaacggucugaagaaccgugugucggcaguucgauucugcccgagaccacca ...<<<<..<<<<........>>>>..<<<<.......>>>>......<<<<<.......>>>>>>>>>....... ....(.(..((((........))))..((((.......))))......(((((.......)))))).)........ 70S ribosome with A*- and P/E-site tRNAs in chloramphenicol-treated Mycoplasma pneumoniae cells; tRNA-Phe 7phc 8 76 9.9 RF00005 URS000054164D_272634 36171285 0030533 0006412 272634 ggucuuguagcucagucgguagagcaacggucugaagaaccgugugucggcaguucgauucugcccgagaccacca ...<<<<..<<<<........>>>>..<<<<.......>>>>......<<<<<.......>>>>>>>>>....... ....(.(..((((........))))..((((.......))))......(((((.......)))))).)........ 70S ribosome with A*- and P/E-site tRNAs in chloramphenicol-treated Mycoplasma pneumoniae cells; tRNA-Phe 7pi8 3 2878 8.9 RF02540,RF02541 URS0000AB9B3C_272634 36171285 0003735 0005840 272634 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<<.......<<<<.<<<<<<....<<<..<<<<<<<<<<<<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>....<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<....<<<<<......>>>>>......<<<<<<<<<.....<<...<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>..>>..>>>>>..>>>>.....<<<<<<<<.......>>>>>>>>.......<<<<..<<<<>>>>...>>>......>>.>>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>.............>....>>>>>>.>>>>.......<<<<..<<<<......>>>>..>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<....<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<.<<........>>.>>>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>..<<<<<<....<<<<<<<<<<.......<.....<..<<<<<...<...........>...>>>>>..>...>........>>>>>>>>>>...>>>>>>.....<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<....>>>>>>>....>>>>>><<<<<<<<<<<<......<<<<<.<<....>>.>>>>>...>>>>>>>>>>.>>.....>>>>>>.......<<...<<<<<<.......>>>>>><<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>....<<<<........>>>>.))<<<<<<<<<<<.<...<<<<<...<<<<..<<<<..<<<<<<<<<.....[[...>>>>><<..<<<<<..<<<<.<<<<<<.<<.....>>>>>>>>.....>>>>..>>>>>...>>...<<.......>>....>>>>....>>>>...>>>>........>>>>>..>......>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>...>>>..<<<<<...<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<......>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<..<<<<<<..<<....>>...>>>>>>..>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<.<<<.......>>>.>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>>>>>>>>...........<<<<<........>>>>>..<<<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<.<<<.<<<...<<<...........<<<<<..<<.......<<<<<<........>>>>>>....>>.............>>>>>..>>>...>>>.>>>.>>...<<<..<<<<<.....>>>>>.>>>....>>>>>>>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>..........(((......>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..>>>>..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>>>....<<<<<<<....<<<..<<<<<<<...............>>>>>>><<<<<<...<<<<...<<<<<<<<<<<.]].>>>>>>..>>>>>...>>>>.>>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>........>>>>>>>..................<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>.....>> .(.(......(((.(((((.....(((..((((((((.((((......((((((....[[[.))).....((.(((...(((]]]....)))......))).))...)))....(((....)))(((((.((....)).)))))..((((((((.........))))))))..))....(((((......(...[..).......)))).).........((....))...(((((.....(..]....)....)))))...((((...(.(((......))).)......((((((.((......(...((((((((((.(((...(((((......)))))[[......(((.....]])))...)))...))))))))))..)...)).))..)))))....(((((((((.[..).)))))))).......((((]..[[[))))...)))......))..)))))).))...............((....))....)).........((((....)))).............).....))))).)))......(.(.((...(((..[...)))...)).).<.(.(........).).((((((....(((.(((.(((.(....(....(((.....)))....)....((....))..(.((.....)).)....).))).))).)))..((.(...(((.((.....(((((.((((.((((....(((((......)))))....)<)))...(((.((.((........)).)))))..).))).))))).(.((.......))...)..)).)))......).))..(((.((....(((((....)))))(.((((((....(((((((((......(.(........((.((...(...........)...)).))......)..)......)))))).)))..))))))..)..(((((((..(......)..)))))))....(((......)))....(((.(((...((([[[...(((((((.....(.....((..(..(((.(.(.....{..((((.(((..(((.........)))..))).....(...((......)).).))))....).).)))..).))...........]]].)...))))))))))...)))))).(.(((((....))))).)....)).)))(..(((...(((......(.(((.((....))]))).)...)))...)))...).....)))))).......((...((((((.......)))))).(............((..(((((((...((.....)).))))))....[[.(((.((.(.(((...(((....)))...)))..)))...(((((........)))))]]....((((((.(....(((((...((((..(((....((((((((.....{{...)))))((..(((((..(((((.(((...((.....))..))).)....))))..)))))...))...(.........)....)))......)))...))))(..)....)))))...)......))))))....)))..))).....((......))......((((.....)))).....)..((((....((((((((.((..(....(........((((....(.[..).....)))).((((((......))))))(...).......(.((((..(.>.((.........))...((.(.((.....(((....))).......)).).)).]((((.(((..((.((((..(((...((....(((...((....))....)))....))...)))))))...)))))(.(((.........))).).........(..........(.(((.......))).)..).......))))....)..)))).).)..))).)))))))).))))))......).[..(((((.....>].)))))..(((((((...((.((......((((.((((((..((((...((((((((.((.(((.((...((((.(......[..(((((..((.......(((((.(......).)))))....))...........].)))))).))).)..)).))).))...(((..(((((.....))))).)))....))))))))....))))..(((......[)))((((((..........]))))))(.((...((.((((.(..((((.........))))....)......[[[......)))).))...((((..(((...{..)))..)))).(((....))).))]]].......((.((((.((..]]]...)))))).)).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..((((((.((......)).)))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....))..))..)))))))[...(((((((....(((..(.(((((.....(....)....))))).).(((((...((((...((((.((.(((.}}.))).))...))))...)))).)))))...(.(....((.(.....}.......).))....).).)))...]....)))))))(.................(((((((((.......)))))....(((.((((.(((....(((((....)))))...)))..))))..)))...))))...))). 70S ribosome with P-site tRNA in spectinomycin-treated Mycoplasma pneumoniae cells; 23S ribosomal RNA 7pi8 4 105 8.9 RF00001 URS000000E851_272634 36171285 0003735 0005840 272634 uuuggugcccaugucgcuguggaaacaccugguuccauuucgaacccagcaguuaagcacaguggagccgaauguagcugcagugagaauaggaaagcaccaagc .<<<<<<......<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<.....<............>...>>....>>>>>>.. ((((((((.....((.(((((.....((((((...(.....)...))))..))....)))))..))..(.......(......).......)....)))))))). 70S ribosome with P-site tRNA in spectinomycin-treated Mycoplasma pneumoniae cells; 5S ribosomal RNA 7pi8 5 1493 8.9 RF00177,RF01959,RF01960 URS00019B76CF_272634 36171285 0003735 0005840 272634 ucugagaguuugauccuggcucaggauuaacgcuggcggcaugccuaauacaugcaagucgaucgaaaguaguaauacuuuagaggcgaacgggugaguaacacguauccaaucuaccuuauaaugggggauaacuaguugaaagacuagcuaauaccgcauaagaacuuugguucgaaucaaaguugaaaggaccugcaaggguucguuauuugaugagggugcgccauaucagcuaguuggugggguaacggccuaccaaggcaaugacguguagcuaugcugagaaguagaauagccacaaugggacugagacacggcccauacuccuacgggaggcagcaguagggaauuuuucacaaugagcgaaagcuugauggagcaaugccgcgugaacgaugaaggucuuuaagauuguaaaguucuuuuauuugggaagaaugacuuuagcagguaauggcuagaguuugacuguaccauuuugaauaagugacgacuaacuaugugccagcagucgcgguaauacauaggucgcaagcguuauccggauuuauugggcguaaagcaagcgcaggcggauugaaaagucugguguuaaaggcagcugcuuaacaguuguaugcauuggaaacuauuaaucuagagugugguagggaguuuuggaauuucauguggagcggugaaaugcguagauauaugaaggaacaccaguggcgaaggcgaaaacuuaggccauuacugacgcuuaggcuugaaaguguggggagcaaauaggauuagauacccuaguaguccacaccguaaacgauagauacuagcugucggggcgauccccucgguagugaaguuaacacauuaaguaucucgccuggguaguacauucgcaagaaugaaacucaaacggaauugacggggacccgcacaagugguggagcauguugcuuaauucgacgguacacgaaaaaccuuaccuagacuugacauccuuggcaaaguuauggaaacauaaugccgagugacagguggugcaugguugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuuaucguuaguuacauugucuagcgagacugcuaaugcaaauuggaggaaggaagggaugacgucaaaucaucaugccccuuaugucuagggcugcaaacgugcuacaauggccaauacaaacagucgccagcuuguaaaagugagcaaaucuguaaaguuggucucaguucggauugagggcugcaauucguccucaugaagucggaaucacuaguaaucgcgaaucagcuaugucgcggugaauacguucucgggucuuguacacaccgcccgucaaacuaugaaagcugguaauauuuaaaaacguguugcuaaccauuaggaagcgcaugucaaggauagcaccggugauuggaguuaagucguaacaagguaccccuacgagaacguggggguggauca .....<<<<....((([.>>>>..<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<<<<<....>>>>>>.>>>>>......<<........<<<.<<<..<<......<<<<<<.<<.....<<<<<<....>>>>>>......>>.>.....<<<<<<<<<...>.>>>>>>>>....<<<<<<....>>>>>>>>>>>.....>>>>>.>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>...>>>>>.>>.<<<<<............>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<.....>>>>.....>>>>...<<..<<<.......<<<<<<<<<........>>>>>>>>.>.......>>>...>>.....<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>...........<<<((.....<<<<...<<<.<<<<<<..<<<<<<<<<<.....<<<<<<<.....>>>>>>>..>>>>>>>>..>>.>>>>>>...<<<.<<<<...<<<<<<<....<<<<<<<<<..<<<......>>>.....>>>>>>>>>...........<<....>>.>>>>>>>..>>>>..>>>...>>>...>>>>....<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<......>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..].)))...<<<<.<<<<<<<.<<.<<<<<...<<<<<<<<<<......<<........>>..........<<<<<<<......<.<<<......<<<<<......>>>>>...>>>..>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<.........>>>>>>>.....<<<<<....>>>>>........>>>>.........>>...>>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>....>>>>>>>......<..<<.<<<<<<........>>>>>>>>...>......>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>.....<..<<.<.<<<<.<<<..<<<<<<..<<<<.....<<<<<.<<<<..<<....>>.>>>>>>>>>....>>>>..>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .....(((.....[[[...))).((((.(((((..((((((.(.....(...(.(..(((..((.((((((....)))))).)))))......(((.......(((..((..((...(.....(((.((.....((((((....))))))......)).).....(((((((........)))))))....(.(((......))).))).....)..))))..))).(((....(((..((((((((.......)))))))))))......)))..(((((.((....)).)...))))))).(((((............))))).((((....))))...).)..).......(.(((...(.(((....)))..))))).)..))))))..((((......((((.....)))).....))))...(....((...(.....(((((((........))))))).....)....)).......)...(.((([[[...(((((.....((.]]])).......)))))))).)..)))))))))..........((([[...(.((((....((.((((((..(.(((((((......(((.(((.....))).)))...)))))))...).))))))..((((.((((....(((((((....(((((.....((........))........)))))....).......((....)).))))))...))))..)))..)))....))))....((((((....(...((((.........))))...).))))))......{...((((((..(((.((((.(.......))))).)))...((..]])).....)))))))))).(((.......(((....))).....)))....]]]....((..(((((((.((..(((.....(((((.(........((........))..........((((..(..(......((.(......(..(....)...)..).).)...).((.(((...((.(((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((.........)))))))..(..(((((....))))).....)..)))).....).).))....)).)))))....)..))))......).)))))..(...((((((......(((..(((..(((....))).).))....))).....))))))......(.....((((.(........).)))).....)..)....))).....(.(((((..........))))).)......))...))))))).)).....(.(..((....(((.(.(..((((((...((((....(((((..(((..((....)).))).)))))...))))...))))))..).).))).....))...)..)..(((((((((....)))))))))}..... 70S ribosome with P-site tRNA in spectinomycin-treated Mycoplasma pneumoniae cells; 16S ribosomal RNA 7pi8 7 76 8.9 RF00005 URS000054164D_272634 36171285 0030533 0006412 272634 ggucuuguagcucagucgguagagcaacggucugaagaaccgugugucggcaguucgauucugcccgagaccacca <<<<<<<..<<<<........>>>>..<<<<.......>>>>......<<<<<.......>>>>>>>>>>>>.... .((((.(..((.(........).))..((((.......))))......(((((.......)))))).))))..... 70S ribosome with P-site tRNA in spectinomycin-treated Mycoplasma pneumoniae cells; tRNA-Phe 7pi9 3 2878 6.3 RF02540,RF02541 URS0000AB9B3C_272634 36171285 0003735 0005840 272634 aguuacuaagggcuuaugguggaugccuuggcacuaauaggcgaugaaggacguguuaaccugcgauaagcuucggguaggugguaagaaccucagauccggagauuuccgaauggagcaauccgguaguuggaaacagcuaucauuaauugaugaauaaauagucaauuaaagcaauacguggugaagugaaacaucucaguagccacaggaaaagaaaacgaaugugauuccguguguaguggcgagcgaaagcggaacaggccaaacuuaucauuagauagggguuguagggcuugcaauguggacuugaaaacgauagaagaagcuguuggaaagcagcgcgcaaaagggugauagccccguauuugaaauuguuuucauaccuagcgagaucccugaguagcucggaaaacguuauuuugagugaaucugcccagaccauuggguaagccuaaauacuaauuagugaccgauagcgaaacaguaccgugagggaaaggugaaaagaacccagagaugggagugaaauagauucugaaaccauaugccuacaacgugucagagcacauuaaugugugauggcgugcguuuugaaguaugagccggcgaguuaugauagcaagcguuaguuaaccaggagauggggagcuguagcgaaagcgaguuuuaaaagagcguuuguuuguuauuauagacccgaaacggguugagcuagucaugagcagguugaagguugaguaacaucaacuggaggaccgaaccgacucucguugaaacgauagcggaugacuugugauuaggggugaaauuccaaucgaaauccgugauagcugguucucgucgaaauagcuuuaaggcuagcgugagaucacaaauaaguggagguaaagcuacugaauguaugauggcgccggcguacugaauacaauuaaacucugaaugccauuuauuuuauucucgcagucagacagugggggauaagcuucauugucaagaggggaagagcccagaucauuaaauaagguccccaaaauauacuaaguggaaaaggaugugaaagugcuaaaacagcaaggauguuggcuuagaagcagccaucguuuaaagagugcguaacagcucacuugucgaguguuuuugcgccgaagauguaacggggcuaaguauauuaccgaauuuauggauaagauuuauaucuugugguagacgagcguuguauuggaguugaagucaaagcgugagcauugguggauccaauacaagugagaaugccggcaugaguaacgcuugggagugagaaucucccaaaccgauugacuaagguuuccuggaccagggucguccuuccaggguuagucuggaccuaagcugaggcugaaaagcguaggcgauggacaacagguuaauauuccuguacuuacaguuagacugauggagugacaaagaagguuuuccacccccauaauuggauuuggggauaaaucauaaggugguacaauaggcaaauccguugugcauaacauugagugaugaugucgagugaaaguagcgaaggugguauuaaucaugcuuucaagaaaagcuucuaggguuaaucuagcuguaaccaguaccgagaacgaacacacguagucaaggagaggauccuaagguuagcgagugaacuauagccaaggaacucugcaaauuaaccccguaaguuagcgagaaggggugcuuauguaaaaguaagccgcagugaagaacgaggggggacuguuuaacuaaaacacaacucuaugccaaaccguaaggugauguauauggggugacaccugcccagugcuggaagguuaaagaaggagguuagcgcaagcgaagcuuuuaacugaagccccagugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuagucggguaaauuccgucccgcuugaaugguguaaccaucucuugacugucucggcuauagacucggugaaauccagguacgggugaagacacccguuaggcgcaacgggacggaaagaccccgugaagcuuuacuguagcuuaauauugaucaggacauuaucauguagagaauagguaggagcaaucgaugcaaguucgcuaggacuuguugaugcgaaagguggaauacuacccuugguugugugcuguucuaauugguaacuguuauccaguuucaagacaguguuaggugggcaguuugacuggggcggucgccuccuaaaagguaacggaggcguacaaagguaccuucaguacgguuggaaaucguauguagaguguaaugguguaagggugcuugacugugagacauacaggucgaacaggugagaaaucaggucauagugauccggugguccaguauggaauggccaucgcucaacggauaaaagcuacuccggggauaacaggcugauacugcccaagaguucauaucgacggcaguguuuggcaccucgaugucgacucaucucauccucgagcugaagcagguucgaaggguucggcuguucgccgauuaaagagauacgugaguuggguucaaaccgucgugagacagguuggucccuaucuauugugcccguaggaagauugaagaguguugcuucuaguacgagaggaccgaagcgaggacaccucuuaugcuccaguuguagcgccagcugcaccgcuggguaguaacgugucuauuagauaaacgcugaaagcaucuaagugugaaacuaucucaaagauuaaucuucccauuucgcaagaaaguaagagccgucaaagacgaugacguugauagguuacagguguaagcauagugauauguugagcugaguaauacuaauugcucgaggacu <<<......<<<<.<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>....<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((....<<<<<......>>>>>......<<<<<<<<<.....<<...<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>..>>..>>>>>..>>>>.....<<<<<<<<.......>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<....>>>>.............}....>>>>>>.>>>>.......<<<<..<<<<......>>>>..>>>>...<<..........>>.<<<<<<....<<<<<<<<<<<<<...<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<.<<........>>.>>>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>..<<<<<<....<<<<<<<<<<......<<....<<..<<<<<...<.<<<<>>>>..>...>>>>>..>>..>>.......>>>>>>>>>>...>>>>>>.....<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<....>>>>>>>....>>>>>><<<<<<<<<<<<......<<<<<.<<....>>.>>>>>...>>>>>>>>>>.>>.....>>>>>>.......<<...<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<.<...<<<<<...<<<<..<<<<..<<<<<<<<<.....[[...>>>>><<..<<<<<..<<<<<<<<<<..<<.....>>.>>>>>>....>>>>..>>>>>...>><..<<.......>>...>>>>>....>>>>...>>>>........>>>>>..>......>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<<...<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<......>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<..<<<<<<..<<....>>...>>>>>>..>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<.<<<.......>>>.>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>>>>>>>>...........<<<<<........>>>>>..<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<<.<<.<<<.<<<<...<<...........<<<<<..<<<......<<<<<<<......>>>>>>>...>>>.............>>>>>..>>...>>>>.>>>.>>...<<<..<<<<<.....>>>>>.>>>....>>>>>>>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<..[.(((.>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<<....<<<..<<<<<<<...............>>>>>>><<<<<<...<<<<...<<<<<<<<<<<.]].>>>>>>..>>>>>...>>>>.>>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>........>>>>>>>..................<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> .((.......(((.(((((.....(((..(((((((((((((......((((((....[[[.))).....((.(((...(((]]]....)))......))).))...)))....(((....)))(.(((.((....)).))).)..(((((((...........)))))))..))....((((((.....(...[..)......)))))..)........((....))...(((((.....((.]...))....)))))...((((...(((((......)))))......(((((((((.....((...((((((((((..((...((((........))))[[......(((.....]])))...))....))))))))))..))..)))))..))))).....((((.(((.[..).)).)))).......(((((]..[[[)))))..)))......)).))))))).))...............((....))....))......(..((((....))))............)).....))))).)))........(.((...(((..[...)))...)).).<.(((........))).((((((....(((.(((((((((....(....(((.....)))....)....((....))..(.(.......).)....))))))))).)))..((.(...(((.((.....(.((((.(((.(((.....(((((......)))))......)))...(((.((.((........)).)))))..).)).)))).).(.((.......))...)..)).)))......).))..((((((....(((((....)))))(.((((((....((((((.(((.....(((....(((.((((....(((......)).)....)))).)))..)).).....))).))))))...))))))..)..((((.(((((......))))).))))....(((......)))...((...(((...((([[[....((((.......(.....((..(.((((.(.(.......(((((.(.(..(((.........)))..).).....(...((......)).).)))).)..).).)))).).))...........]]].).....))).))))...)))..))(((((((....)))))))....))))))(.(((((..(((......(((((.((....))])))))...)))..)))))..).....))))))............((((((.......))))))(..(...[((.(..(....((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]](.((((((((((....(((((...((((..(..(..(((((((((.....{{...)))))(...((((...(((((.((((..((.....)).)))).)....))))...))))....)(..((.......))...)))))....)..)...))))(..)....)))))...).....))))))))).)))))...).....((......))..))).((((.....))))..)..)].((((....((((((((.((..(....(.......(((((....(.[..).....)))))((((((......))))))(...).......((((.(.((...((.........))...((((.((.....(((....))).......)).)))).]((((.(((..(((((((..(((...((....(.((..((....))...)).)....))...))))))))..)))))(.(((.........))).)........((..........(.(((.......))).)..)..)....))))...))..).)))).)..))).)))))))).))))..........[..(((((.....>].)))))..(((((((..(((.((......((((.((.(((..(((((.((.((((((.((.(((.(((....((.(......[..(((((..(((.......(((((((....)))))))....)))...........].)))))).))....))).))).))...(((..(((((.....))))).)))....)))))).))..)))))..(((......[)))((((((..........]))))))(.((....(.(((..(..((((.........))))....).(..[.[[[.).....))).)....((((..(((...{..)))..)))).(((....))).))]]].].....((((((..((..]]]...)).)))))).....)}......)))...))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.(..(((..((((((.((......)).)))..))).(((((.....))))).....)))....)...))).).....(((((((....))).))))....))..))).)))))))[...(((((((....(((..(((((((.....(....)....)))))))((((((...((((...(((((((.(((.}}.))).))..)))))...)))).))))))..(((....((.(.............).))....))).)))...]....)))))))(...(.......).....(((((((((.......)))))....(((.((((..((....(((((....)))))...))...))))..)))...))))...))). 70S ribosome with EF-Tu-tRNA and P-site tRNA in spectinomycin-treated Mycoplasma pneumoniae cells; 23S ribosomal RNA 7pi9 4 105 6.3 RF00001 URS000000E851_272634 36171285 0003735 0005840 272634 uuuggugcccaugucgcuguggaaacaccugguuccauuucgaacccagcaguuaagcacaguggagccgaauguagcugcagugagaauaggaaagcaccaagc .<<<<<<<.....<<<<<<<<.....<<<<<<.............>>>>..>>....>>>>>>.>>.<<.....<.<<<..>>>...>...>>...>>>>>>>.. .(((((((.....((.(((((.....((((((...(.....)...))))..))....)))))..)).((.......(......).......))...)))))).). 70S ribosome with EF-Tu-tRNA and P-site tRNA in spectinomycin-treated Mycoplasma pneumoniae cells; 5S ribosomal RNA 7pi9 5 1493 6.3 RF00177,RF01959,RF01960 URS00019B76CF_272634 36171285 0003735 0005840 272634 ucugagaguuugauccuggcucaggauuaacgcuggcggcaugccuaauacaugcaagucgaucgaaaguaguaauacuuuagaggcgaacgggugaguaacacguauccaaucuaccuuauaaugggggauaacuaguugaaagacuagcuaauaccgcauaagaacuuugguucgaaucaaaguugaaaggaccugcaaggguucguuauuugaugagggugcgccauaucagcuaguuggugggguaacggccuaccaaggcaaugacguguagcuaugcugagaaguagaauagccacaaugggacugagacacggcccauacuccuacgggaggcagcaguagggaauuuuucacaaugagcgaaagcuugauggagcaaugccgcgugaacgaugaaggucuuuaagauuguaaaguucuuuuauuugggaagaaugacuuuagcagguaauggcuagaguuugacuguaccauuuugaauaagugacgacuaacuaugugccagcagucgcgguaauacauaggucgcaagcguuauccggauuuauugggcguaaagcaagcgcaggcggauugaaaagucugguguuaaaggcagcugcuuaacaguuguaugcauuggaaacuauuaaucuagagugugguagggaguuuuggaauuucauguggagcggugaaaugcguagauauaugaaggaacaccaguggcgaaggcgaaaacuuaggccauuacugacgcuuaggcuugaaaguguggggagcaaauaggauuagauacccuaguaguccacaccguaaacgauagauacuagcugucggggcgauccccucgguagugaaguuaacacauuaaguaucucgccuggguaguacauucgcaagaaugaaacucaaacggaauugacggggacccgcacaagugguggagcauguugcuuaauucgacgguacacgaaaaaccuuaccuagacuugacauccuuggcaaaguuauggaaacauaaugccgagugacagguggugcaugguugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuuaucguuaguuacauugucuagcgagacugcuaaugcaaauuggaggaaggaagggaugacgucaaaucaucaugccccuuaugucuagggcugcaaacgugcuacaauggccaauacaaacagucgccagcuuguaaaagugagcaaaucuguaaaguuggucucaguucggauugagggcugcaauucguccucaugaagucggaaucacuaguaaucgcgaaucagcuaugucgcggugaauacguucucgggucuuguacacaccgcccgucaaacuaugaaagcugguaauauuuaaaaacguguugcuaaccauuaggaagcgcaugucaaggauagcaccggugauuggaguuaagucguaacaagguaccccuacgagaacguggggguggauca .....<<<<..[.(((..>>>>.<<<<.<<<<<..<<<<<<<<.....<<..<<<..<<<..<<.<<<<<<....>>>>>>.>>>>>......<<........<<<<<<<..<<...<...<...<.<<.....<<<<<<....>>>>>>......>>.>.....<<<<<<<<<<.>>.>>>>>>>>....<<<<<<....>>>>>>...>...>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>...>>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>.>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<.......<<<.....>>>......>>>>...<...<<<.........<.<<<<<........>>>>>.>..........>>>....>.....<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<..<<<<<<<<<<.....<<<<<<<.....>>>>>>>..>>>>>>>>..>>.>>>>>>...<<<<<<<<....<<<<<<....<<<<<<<<<..<<<......>>>.....>>>>>>>>>...........<<....>>.>>>>>>...>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<......>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<.....<<<<<....>>>>>...>>>....))).]<<<<<.<<<<<<<.<<.<<<<<...<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<.....<<<<<<....>>>>>>..>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<.........>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>....>>>>>>>......<..<.<<<<<<<........>>>>>>>>...>......>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<..<<<<<....<<<<<<.<<<..<<....>>.>>>>>>>>>...>>>>>..>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .....((((..[.[[[..)))).((.(.(((((..(((((((((....(((.(((..(((..((.((((((....)))))).)))))......(((........(.((((..((...(..(.(..(.((.....(((((......)))))......)).).....(((((((........)))))))....((((((....))))))..).)..)..)))))).)..((.....(((..((((((((.......))))))))))).......))..(((((.((....)).)...))))))).(((((............))))).((((....))).)..)))))).).....(..((...(.(((....)))..))).).)).))))))..((((.......(((.....)))......))))....(..(((...(....(((.((((........)))).)).)...)....)))...)......((((([[[...(((((.....((.]]])).......))))))))))..)))))).))..........((([[...(.((((...(((.((((((..(((((.((((......((.(((.....))).))...)))).)))..)).))))))..((((.((((....(((((((....(((((((...((........))......)))))))....).......((....)).))))))...))))..)))..))))...))))....(.((((...((...((((.........))))...))))))..).....{...((((((...((..((..(.......).))..))....((..]])).....)))))))))).(((.......(((....))).....)))....]]].](((((.(((((((.((..((((...((((((.(..(.....((........))..........(((((((..(...((((((.....((((((....))))))..)))).))).((..((...((.(((.(....((((((.((....))....(((......)))...)))))).....((.(.(((((((.........)))))))..(..(.(((....))).).....)..).)).....).).))....)).).)))....)))))))...)..).)))))).(...(.((((......(((..(((.((((....))))).))....))).....)))).)......(....(((((.(........).)))))....)..)...)))).....(((((((..........)))))))......))...)))))))))).))..(.(..((.(.((((.(((...(((((..(((.(....((((((.(((..((....)).)))))))))...).)))..)))))...))).))))..).))...)..)..(((((((((....)))))))))}..... 70S ribosome with EF-Tu-tRNA and P-site tRNA in spectinomycin-treated Mycoplasma pneumoniae cells; 16S ribosomal RNA 7pi9 6 76 6.3 RF00005 URS000054164D_272634 36171285 0030533 0006412 272634 ggucuuguagcucagucgguagagcaacggucugaagaaccgugugucggcaguucgauucugcccgagaccacca <<<<<<...<<<<........>>>>..<<<<.......>>>>......<<<<<.......>>>>>.>>>>>>.... (((((.(..((((........))))..((((.......))))......(((((.......)))))).))))).... 70S ribosome with EF-Tu-tRNA and P-site tRNA in spectinomycin-treated Mycoplasma pneumoniae cells; tRNA-Phe 7pi9 7 76 6.3 RF00005 URS000054164D_272634 36171285 0030533 0006412 272634 ggucuuguagcucagucgguagagcaacggucugaagaaccgugugucggcaguucgauucugcccgagaccacca <<<<<<...<<<<........>>>>..<<<<.......>>>>......<<<<<.......>>>>>.>>>>>>.... (((((.(..((((........))))..((((.......))))......(((((.......)))))).))))).... 70S ribosome with EF-Tu-tRNA and P-site tRNA in spectinomycin-treated Mycoplasma pneumoniae cells; tRNA-Phe 7pia 3 2878 13.6 RF02540,RF02541 URS0000AB9B3C_272634 36171285 0003735 0005840 272634 aguuacuaagggcuuaugguggaugccuuggcacuaauaggcgaugaaggacguguuaaccugcgauaagcuucggguaggugguaagaaccucagauccggagauuuccgaauggagcaauccgguaguuggaaacagcuaucauuaauugaugaauaaauagucaauuaaagcaauacguggugaagugaaacaucucaguagccacaggaaaagaaaacgaaugugauuccguguguaguggcgagcgaaagcggaacaggccaaacuuaucauuagauagggguuguagggcuugcaauguggacuugaaaacgauagaagaagcuguuggaaagcagcgcgcaaaagggugauagccccguauuugaaauuguuuucauaccuagcgagaucccugaguagcucggaaaacguuauuuugagugaaucugcccagaccauuggguaagccuaaauacuaauuagugaccgauagcgaaacaguaccgugagggaaaggugaaaagaacccagagaugggagugaaauagauucugaaaccauaugccuacaacgugucagagcacauuaaugugugauggcgugcguuuugaaguaugagccggcgaguuaugauagcaagcguuaguuaaccaggagauggggagcuguagcgaaagcgaguuuuaaaagagcguuuguuuguuauuauagacccgaaacggguugagcuagucaugagcagguugaagguugaguaacaucaacuggaggaccgaaccgacucucguugaaacgauagcggaugacuugugauuaggggugaaauuccaaucgaaauccgugauagcugguucucgucgaaauagcuuuaaggcuagcgugagaucacaaauaaguggagguaaagcuacugaauguaugauggcgccggcguacugaauacaauuaaacucugaaugccauuuauuuuauucucgcagucagacagugggggauaagcuucauugucaagaggggaagagcccagaucauuaaauaagguccccaaaauauacuaaguggaaaaggaugugaaagugcuaaaacagcaaggauguuggcuuagaagcagccaucguuuaaagagugcguaacagcucacuugucgaguguuuuugcgccgaagauguaacggggcuaaguauauuaccgaauuuauggauaagauuuauaucuugugguagacgagcguuguauuggaguugaagucaaagcgugagcauugguggauccaauacaagugagaaugccggcaugaguaacgcuugggagugagaaucucccaaaccgauugacuaagguuuccuggaccagggucguccuuccaggguuagucuggaccuaagcugaggcugaaaagcguaggcgauggacaacagguuaauauuccuguacuuacaguuagacugauggagugacaaagaagguuuuccacccccauaauuggauuuggggauaaaucauaaggugguacaauaggcaaauccguugugcauaacauugagugaugaugucgagugaaaguagcgaaggugguauuaaucaugcuuucaagaaaagcuucuaggguuaaucuagcuguaaccaguaccgagaacgaacacacguagucaaggagaggauccuaagguuagcgagugaacuauagccaaggaacucugcaaauuaaccccguaaguuagcgagaaggggugcuuauguaaaaguaagccgcagugaagaacgaggggggacuguuuaacuaaaacacaacucuaugccaaaccguaaggugauguauauggggugacaccugcccagugcuggaagguuaaagaaggagguuagcgcaagcgaagcuuuuaacugaagccccagugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuagucggguaaauuccgucccgcuugaaugguguaaccaucucuugacugucucggcuauagacucggugaaauccagguacgggugaagacacccguuaggcgcaacgggacggaaagaccccgugaagcuuuacuguagcuuaauauugaucaggacauuaucauguagagaauagguaggagcaaucgaugcaaguucgcuaggacuuguugaugcgaaagguggaauacuacccuugguugugugcuguucuaauugguaacuguuauccaguuucaagacaguguuaggugggcaguuugacuggggcggucgccuccuaaaagguaacggaggcguacaaagguaccuucaguacgguuggaaaucguauguagaguguaaugguguaagggugcuugacugugagacauacaggucgaacaggugagaaaucaggucauagugauccggugguccaguauggaauggccaucgcucaacggauaaaagcuacuccggggauaacaggcugauacugcccaagaguucauaucgacggcaguguuuggcaccucgaugucgacucaucucauccucgagcugaagcagguucgaaggguucggcuguucgccgauuaaagagauacgugaguuggguucaaaccgucgugagacagguuggucccuaucuauugugcccguaggaagauugaagaguguugcuucuaguacgagaggaccgaagcgaggacaccucuuaugcuccaguuguagcgccagcugcaccgcuggguaguaacgugucuauuagauaaacgcugaaagcaucuaagugugaaacuaucucaaagauuaaucuucccauuucgcaagaaaguaagagccgucaaagacgaugacguugauagguuacagguguaagcauagugauauguugagcugaguaauacuaauugcucgaggacu .........<<<<.<<<<<<.....<<..<<<<<<<<<..<<......<<<<<<<...(((>>>>.....<<<<<<<..<<<)))....>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<.<<<<.............>>>>..>>>>....<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<....<<<<<......>>>>>.......<<<<<<<<......<...<<<<<<.<<<........<<<<......>>>>.((......<<<.....))>>>.........>>>.>>>>>>...>..>>>>>..>>>......<<<<<<<<.......>>>>>>>>......<<<<<..((((>>>>>..>>>.........>>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>.>>>>.......<<<<..<<<<......>>>>..>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<...<<....<<<.....>>>....>>...<<....>>..<<.........>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<...<<.<<<<......>>>>>>.....>>>...<<<.<<.<<........>>.>>>>>....>>>>>>>>>...<<.......>>......>>>>>>>.....>.>>..<<<.<<....<<<<<....>>>>><<<<<<<<......<<<<<<<<.....<.<.....<..........<...........>..........>...>..>.....>>>>>>>>.....>>>>>>.>>..<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((...<<<<<<<...........<<..<<<.<<<...........<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>.......>>>>.>>.>>...........))).....>>>>>>>>>>...>>>>>>>..<<<<......>>>>......>>.>>><<<<<<<<.<<........<<<<.<<....>>.>>>>.....>>.>>>>>>.>>.....>>>>>>.......<<...<<<<<<.......>>>>>>.<<<.....<.<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<..<<...<<<...<<<....>>>...>>>...>>....<<<<........>>>>.))..<<<<<<<<<.....<<<<<...<<<<..<<<....<<<<<<<<....[[[...>>>>>....<<<<<...<<<<<<<<...<<.....>>..>>>>>....>>>...>>>>>.........<.......>.....>>>......>>>...>>>>........>>>>>.........>>>>>>>>>...>>>..>>.....<<......>>.>.>..<<<<.....>>>>..>>>...<<<<<...<<<<<<<<.<<...............<<<<<...............>>>>><<<<<........>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>..<<<<.<<<..<<<<<<<..<<<........<.<<...<<....>>....>>>.........>>>>>>>>..>>>>>.<<<<<.......>>>>>.....................<.<<<.......>>>.>..........>>>>...>>.>>>>>>>.....>>.>>>>>>>>>>>>>>>...........<<<<<........>>>>>..<<<<<<<..<<<.<<......<<<<.<<<<<<..<<<<..<<<<<<<...<<.<<<.<<<...<<<...........<<<<<..<<.......<<<<<<<......>>>>>>>....>>.............>>>>>..>>>...>>>.>>>.>>...<<<..<<<<<.....>>>>>.>>>......>>>>>>>...>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>............(......>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>).........<<<<<<..<<..))))..>>.>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.........<<<..<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>......>>>.......<<<<<<<....>>>.>>>>....>>..>>>.>>>>>>>....<<<<<<<....<<<..<<<<<<<.....<....>....>>>>>>><<<<<<...<<<<...<<<<<<<<<<<.]]]>>>>>>..>>>>>...>>>>.>>>>>>..<<<....<<.<<...........>>.>>....>>>.>>>........>>>>>>>..................<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....... ..(.......(((.(((((.....(((..((((((.(..((.......(((((......[[..)).....((.(((...(((]].....)))......))).))...)))....((......))(((((.((....)).)))))..(.((((.............)))).)...)....((((((.....(......)......))))).).........((....))...(((((.....((.....))....)))))...((((...(((((......))))).......((((.(((......(...(((((((.((...(...((((........))))[[......(((.....]])))...).....)).)))))))...)..))).)..))).)....((((.((((.[..).))).))))......(((((]..[.[)))))..)))......)...).)))).))...............((....))....))..........(((....)))..............).....))))).)))......(.((((...(((..[...)))...)))).<.(.(........).)...((((....(((((((.(((.(....((...(((.....)))...))....((....))..(.(.......).)....).))).)))))))..((.(...((((((.....(((((.((((.(((...((.(.((......))).))....<)))...(((.((.((........)).)))))..).))).))))).(.((.......))...)..))))))......).))..(((.((....((((......))))....(((((.).(.(((..(.......(((....(((.........(....().....).........)))..)).).......)..)))..)..)))).......((((((((.(......).))))))))....(((......)))....(((.(((...((([[[...((.((((.....(.....((..(.(.((...(........((((.(((..(((.........)))..))).....(...((......)).).))))....)...)).).).))...........]]].)...)))).)))))...)))))).(.(.(((....))).).)....)).)))(((((((..((.........(((.((....))])))......))..))))).)).....))).)........((...((((((.......))))))(.((..........((..(((((((...((.....)).))))))....[[(.((.((..((((...(((....)))...)))..)))....((((........)))).]].(((((.(((......(.......(.((..(..(...((((((((.....{{...)))))(...(((((....(((.(((...((.....))..))).)....))....)))))....)(................))))......).)...)).)(..)........)..........))).))))).)).).))).....((......)).......(((.....)))...)).)..(((((...((((((((.((..(....(.........(((....(.[..).....)).).(((((........)))))(...).......((.((((((.>.((.........))...(((((((.....(((....))).......))))))).]((((.(((..(..((((..(((....(.....(((..((....))..).))......)...)))))))....))))(.(((.........))).)........((..........(.(((.......))).)..)..)....))))...)).)))).)).)..))).)))))))))))))))......).[..(((((.....>].)))))..(((((((..(((..(......((((.((((((..(((((..(.(((((..((.((.((((....((.(......[..(((.(..((........((((..........)))).....))...........].).)))).))....))).))).))...(((..(((((.....))))).))).....))))).)...)))))..(.(......[).)((((((..........]))))))(.......(.((((.(..((((.........))))....)........[......)))).)....((((..(((...{..)))..)))).(((....)))...].........((((.(..((..].]...))..))))).....)}......))))..)))))).......((((.(.((((((...((.......))...))))))...)))).)........(.((.((((((..((.((..(........)..))...)).(((((.....))))).....)))))..)...))..).....(.(((((....))).)).).....)..))).)))))))[...(((((((....(((..(((((((.....(....)....))))))).(((((...(((....(((((((.(((.}}.))).))..)))))....))).)))))....((....((((.............))))....))..)))...]....)))))))(.(...............(((((((((.......)))))....(((.((((..(.....(((((....)))))....)...))))..)))...)))).).)).. 70S ribosome with A/P- and P/E-site tRNAs in spectinomycin-treated Mycoplasma pneumoniae cells; 23S ribosomal RNA 7pia 4 105 13.6 RF00001 URS000000E851_272634 36171285 0003735 0005840 272634 uuuggugcccaugucgcuguggaaacaccugguuccauuucgaacccagcaguuaagcacaguggagccgaauguagcugcagugagaauaggaaagcaccaagc ..<<.<.<.....<.<<<<<<.....<<<<<...............>>>..>>....>>>>>>..>.<<...<...<<....>>....>..>>...>.>.>>... ...(....(....((.(((((.....((((((...(.....)...))))..))....)))))..))......(..............)........)...).... 70S ribosome with A/P- and P/E-site tRNAs in spectinomycin-treated Mycoplasma pneumoniae cells; 5S ribosomal RNA 7pia 5 1493 13.6 RF00177,RF01959,RF01960 URS00019B76CF_272634 36171285 0003735 0005840 272634 ucugagaguuugauccuggcucaggauuaacgcuggcggcaugccuaauacaugcaagucgaucgaaaguaguaauacuuuagaggcgaacgggugaguaacacguauccaaucuaccuuauaaugggggauaacuaguugaaagacuagcuaauaccgcauaagaacuuugguucgaaucaaaguugaaaggaccugcaaggguucguuauuugaugagggugcgccauaucagcuaguuggugggguaacggccuaccaaggcaaugacguguagcuaugcugagaaguagaauagccacaaugggacugagacacggcccauacuccuacgggaggcagcaguagggaauuuuucacaaugagcgaaagcuugauggagcaaugccgcgugaacgaugaaggucuuuaagauuguaaaguucuuuuauuugggaagaaugacuuuagcagguaauggcuagaguuugacuguaccauuuugaauaagugacgacuaacuaugugccagcagucgcgguaauacauaggucgcaagcguuauccggauuuauugggcguaaagcaagcgcaggcggauugaaaagucugguguuaaaggcagcugcuuaacaguuguaugcauuggaaacuauuaaucuagagugugguagggaguuuuggaauuucauguggagcggugaaaugcguagauauaugaaggaacaccaguggcgaaggcgaaaacuuaggccauuacugacgcuuaggcuugaaaguguggggagcaaauaggauuagauacccuaguaguccacaccguaaacgauagauacuagcugucggggcgauccccucgguagugaaguuaacacauuaaguaucucgccuggguaguacauucgcaagaaugaaacucaaacggaauugacggggacccgcacaagugguggagcauguugcuuaauucgacgguacacgaaaaaccuuaccuagacuugacauccuuggcaaaguuauggaaacauaaugccgagugacagguggugcaugguugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuuaucguuaguuacauugucuagcgagacugcuaaugcaaauuggaggaaggaagggaugacgucaaaucaucaugccccuuaugucuagggcugcaaacgugcuacaauggccaauacaaacagucgccagcuuguaaaagugagcaaaucuguaaaguuggucucaguucggauugagggcugcaauucguccucaugaagucggaaucacuaguaaucgcgaaucagcuaugucgcggugaauacguucucgggucuuguacacaccgcccgucaaacuaugaaagcugguaauauuuaaaaacguguugcuaaccauuaggaagcgcaugucaaggauagcaccggugauuggaguuaagucguaacaagguaccccuacgagaacguggggguggauca .....<<<<..[.(((..>>>>...<<.<<<<<..<<<<<.<<.....<<<.<<<..<<<..<<.<<<<<<....>>>>>>.>>>>>......<<........<<<.<<................<.<<.....<<<<<......>>>>>......>>.>.....<.<<<<..........>>>>.>....<<<<<<....>>>>>>.............>>.>>>.<<.....<<...<<<<<<<<.......>>>>>>>>.>>.......>>..<<<..<<<....>>>.....>>>.>>.<<<<<............>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>..>>>>>..<<<<........<<.....>>.......>>>>.......<<<........<<<<<<<<........>>>>>>>>.........>>>..........<<<<<((....<<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>>............<<<((.....<<<<....<<.<<<<<...<<<<<.<<<<.....<<<<<<<.....>>>>>>>..>>>>.>>>..>>..>>>>>...<<<.<<<<...<<<<<<<....<<<<<<<<<..<<........>>.....>>>>>>>>>...........<<....>>.>>>>>>>..>>>>..>>>...>>....>>>>....<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<......>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<.....<<<<<....>>>>>...>>>....))).]..<.....<<<<..<<..<<<<..<<<<<<<<<........<<........>>..........<<<<<<<........<............<<....>>.........>....<<<.<<<..<<<<<........<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<..<<<<<<<.........>>>>>>>.....<<..........>>.........>>>..........>...>>>>>>>>>>...>>>>>>>......>>>>>>>>.>...<<<<<<......<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>......<....<<<<<<<........>>>>>>>....>......>>>>.......<<<<<..........>>>>>........>>....>>>>....>.......<..<<.<.<<<<.<<<..<<<<<<..<<<<.....<<<<<<.<<<..<<....>>.>>>>>>>>>....>>>>..>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .....((((..[.[[[..))))..((..(......(((...(((....(((.(((..(.(..((.((((((....)))))).))).)......(((.......((..((........(......((.((.....((.(((....))).))......)).).....((((.(..........).))))....((((((....)))))))......).....))..)).((.....(((..(((((.((.......)).)))))))).......))..(((...((....))......)))))).(((((.(.........)))))).((((....))).)..)))))).).....(..((...(.(((....)))..))).).))....)))..((((........((.....)).......)))).......(((...(....((((((((........))))))))....)....)))..........(.((([.[...(((((.....((.].])).......)))))))).)......).))...........((([[...(.((((....((.(((...(.((((.((((.......((((((.....))))))....)))).))..)).)..)))..(((..(((....((((((((...(((((.((...((........))......)).)))))...).......((....)).)))))))...)))...))..)))....))))....((((((....(...((((.........))))...).))))))......{...((((((..(((((((.((......)).)))))))...((..]])).....)))))))))).(((.......(.(....))......)))....]]].].((.(..(..(((....((((....((.(.(((((......((........))...........((((....(...(.(..(.......(.((....))..)...)..).).).((.((....((..((.(....((((((..(....).....(((......)))...)))))).....((.(.(((((.(.........).)))))..(..(((.(....).))).....)..).)).....).).).....))..))))......))))....)).))).).)).(...((((((......(((..(((.((((....))))).))....))).....))))))......(....(((((.(........).)))))....)..)....))))......(((((..........))))).............)))...)).).)...(.(..((.(..(((..((..((((((..(((......((((((.(.(..((....)).).))))))).....)))..))))))..))..)))...).))...)..)..(((((((((....)))))))))}..... 70S ribosome with A/P- and P/E-site tRNAs in spectinomycin-treated Mycoplasma pneumoniae cells; 16S ribosomal RNA 7pia 7 76 13.6 RF00005 URS000054164D_272634 36171285 0030533 0006412 272634 ggucuuguagcucagucgguagagcaacggucugaagaaccgugugucggcaguucgauucugcccgagaccacca <<<<<....<<<<........>>>>..<<<<.......>>>>......<<<<<.......>>>>>..>>>>>.... ((((..(..((.(........).))..((((.......))))......(((((.......))))))..)))).... 70S ribosome with A/P- and P/E-site tRNAs in spectinomycin-treated Mycoplasma pneumoniae cells; tRNA-Phe 7pia 8 76 13.6 RF00005 URS000054164D_272634 36171285 0030533 0006412 272634 ggucuuguagcucagucgguagagcaacggucugaagaaccgugugucggcaguucgauucugcccgagaccacca <<<<<....<<<<........>>>>..<<<<.......>>>>......<<<<<.......>>>>>..>>>>>.... ((((..(..((.(........).))..((((.......))))......(((((.......))))))..)))).... 70S ribosome with A/P- and P/E-site tRNAs in spectinomycin-treated Mycoplasma pneumoniae cells; tRNA-Phe 7pib 3 2878 4.7 RF02540,RF02541 URS0000AB9B3C_272634 36171285 0003735 0005840 272634 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.........<<<<.<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>....<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...(((....<<<<<......>>>>>......<<<<<<<<<.....<<...<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>..>>..>>>>>..>>>>.....<<<<<<<<.......>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<....>>>>.............}....>>>>>>.>>>>.......<<<<..<<<<......>>>>..>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<....<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>..<<.<..<<<<<<<......<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<.<<........>>.>>>>>....>>>>>>>>....<<.......>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<....<<<<<<<<<.......<<....<<..<<<<<....<<......>>.....>>>>>..>>..>>........>>>>>>>>>...>>>>>>.>>..<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<......>>>>>>....>>>>>><<<<<<<<<<<<......<<<<<.<<....>>.>>>>>...>>>>>>>>>>.>>.....>>>>>>.......<<...<<<<<<.......>>>>>>.<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<.<...<<<<<....<<<..<<<<..<<<<<<<<<....(((...>>>>><<..<<<<<..<<<<<<<<<<<.<<.....>>>>>>>>>....>>>>..>>>>>...>>...<<.......>>....>>>>....>>>>...>>.>........>>>>>..>......>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>...<.......>.....>>...<<<<<...<<<<<<<<.<<...............<<<<<....<<..>>.....>>>>><<<<<<......>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<..<<<<<<..<<....>>..>.>>>>>..>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<.<<<<.....>>>>.>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>>>>>>>>...........<<<<<........>>>>>..<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<<.<<.<<<.<<<..<<<<...........<<<<<..<<.......<<<<<<<......>>>>>>>....>>.............>>>>>..>>>>..>>>.>>>.>>...<<<..<<<<<.....>>>>>.>>>....>>>>>>>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<<....<<<...<<<<<<.....<....>....>>>>>>.<<<<<<...<<<<...<<<<<<<<<<<.)))>>>>>>..>>>>>...>>>>.>>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>........>>>>>>>..................<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....... ..........(((.(((((.....(((..(((((((((((((......((((((....[[[.))).....((((((...(((]]]....)))......))))))...)))....(((....)))((((((((....)))))))).(((((((((.........))))))))).))....((((((.....(...[..)......))))).).........((....))...(((((.....(..]....)....)))))...((((...(((((......)))))......((((((.((.....((...((((((((((.(((...(((((......)))))[[......(((.....]])))...)))...))))))))))..))..)).))..)))))....(((((.(((.[..).)).)))))........(((].[[[[)))....)))......)).))))))).))...............((....))....)).........((((....)))).............).....))))).)))........((((..((((..[...))))..))))...(((........))).((((((....(((((((((((((....(....(((.....)))....)....((....))..((((.....))))....)))))))))))))..((.(...((((((.....((((((((((.((((....(((((......)))))....)<)))...(((.((.((........)).)))))..).))))))))).(.((.......))...)..))))))......).))..((((((....(((((....))))).((.(((.....((((((..(......(((....(((.(...........................).)))..)).)......)..))))))....))).).)...((((((((((......))))))))))....((.(.....)))....(((.(((...((([[[...(.((.((.....(.....((..((.(((..((.....{.(((((.(((..(((.........)))..))).....(...((......)).).)))))...))..))).)).))...........]]].)...)).)).))))...)))))).(((((.(....).)))))....))))))(.(((((..(((......(((((.((....))])))))...)))..)))))..).....))))))............((((((.......))))))(..(....(.(...((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]]((((((((((.(....(((((...(((...((((..(((((((((.....{{...)))))((..(((((..((((((((((..((.....)).))))))....))))..)))))...))(..(.........)...)))))....))))....)))(..)....)))))...)......)))))))))))))).))).....((......))..).).(((.......)))...).)..((((....((((((((.((..(....(.......(((((....(.[..).....)))))(((((........)))))(...).......(((((((((.>.((.........))...(((((((.....(((....))).......))))))).]((((.(((..(((((((..(((...((....(.((..((....))...)).)....))...))))))))..)))))(((((.........)))))........((..........(.(((.......))).)..)..)....))))...)).))))))).)..))).)))))))).))))..........[..(((((......].)))))..((((((....((.((.......(((.((((((..(((((.(((((((((.((.(((.((...(.((.(......[..((.((..(((......((((((.(.....)))))))...)))...........].)).))).)).)...)).))).))...(((..(((((.....))))).)))....)))))))))..)))))..(((......[)))((((((..........]))))))(.((...((.((((.(..((((.........))))....).((...[[[))....)))).))...((((..(((...{..)))..)))).(((....))).))]]]........((((((.((..]]]]..))))))))......)}......))))..)))))........((((.(.((((((...((.......))...))))))...)))).)........((((.((((((..((.((((((......))))))...)).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....))..))...))))))[...(((((((....(((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).)))...]....)))))))(...(.......).....(((((((((.......)))))....(((.((((.(((.....((((....))))....)))..))))..)))...))))...)... 70S ribosome with EF-G, A/P- and P/E-site tRNAs in spectinomycin-treated Mycoplasma pneumoniae cells; 23S ribosomal RNA 7pib 4 105 4.7 RF00001 URS000000E851_272634 36171285 0003735 0005840 272634 uuuggugcccaugucgcuguggaaacaccugguuccauuucgaacccagcaguuaagcacaguggagccgaauguagcugcagugagaauaggaaagcaccaagc <<<<<<<<.....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<..<..<.<<<..>>>...>.>.>>...>>>>>>>>. ((.((.((.....((((((((.....((((((...(.....)...))))..))....)))))).))..............................)).)).)). 70S ribosome with EF-G, A/P- and P/E-site tRNAs in spectinomycin-treated Mycoplasma pneumoniae cells; 5S ribosomal RNA 7pib 5 1493 4.7 RF00177,RF01959,RF01960 URS00019B76CF_272634 36171285 0003735 0005840 272634 ucugagaguuugauccuggcucaggauuaacgcuggcggcaugccuaauacaugcaagucgaucgaaaguaguaauacuuuagaggcgaacgggugaguaacacguauccaaucuaccuuauaaugggggauaacuaguugaaagacuagcuaauaccgcauaagaacuuugguucgaaucaaaguugaaaggaccugcaaggguucguuauuugaugagggugcgccauaucagcuaguuggugggguaacggccuaccaaggcaaugacguguagcuaugcugagaaguagaauagccacaaugggacugagacacggcccauacuccuacgggaggcagcaguagggaauuuuucacaaugagcgaaagcuugauggagcaaugccgcgugaacgaugaaggucuuuaagauuguaaaguucuuuuauuugggaagaaugacuuuagcagguaauggcuagaguuugacuguaccauuuugaauaagugacgacuaacuaugugccagcagucgcgguaauacauaggucgcaagcguuauccggauuuauugggcguaaagcaagcgcaggcggauugaaaagucugguguuaaaggcagcugcuuaacaguuguaugcauuggaaacuauuaaucuagagugugguagggaguuuuggaauuucauguggagcggugaaaugcguagauauaugaaggaacaccaguggcgaaggcgaaaacuuaggccauuacugacgcuuaggcuugaaaguguggggagcaaauaggauuagauacccuaguaguccacaccguaaacgauagauacuagcugucggggcgauccccucgguagugaaguuaacacauuaaguaucucgccuggguaguacauucgcaagaaugaaacucaaacggaauugacggggacccgcacaagugguggagcauguugcuuaauucgacgguacacgaaaaaccuuaccuagacuugacauccuuggcaaaguuauggaaacauaaugccgagugacagguggugcaugguugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuuaucguuaguuacauugucuagcgagacugcuaaugcaaauuggaggaaggaagggaugacgucaaaucaucaugccccuuaugucuagggcugcaaacgugcuacaauggccaauacaaacagucgccagcuuguaaaagugagcaaaucuguaaaguuggucucaguucggauugagggcugcaauucguccucaugaagucggaaucacuaguaaucgcgaaucagcuaugucgcggugaauacguucucgggucuuguacacaccgcccgucaaacuaugaaagcugguaauauuuaaaaacguguugcuaaccauuaggaagcgcaugucaaggauagcaccggugauuggaguuaagucguaacaagguaccccuacgagaacguggggguggauca .....<<<<..[.(((..>>>>.<<<<.<<<<<..<<<<<<<<.....<<<..<<..<<<..<<.<<<<<<....>>>>>>.>>>>>......<<........<<<<<<<..<<...<..<<<<<<.<<....<<<<<<<....>>>>>>.>....>>.>.....<<<<<<<..<.>...>>>>>>>....<<<<<<....>>>>>>>>>>>..>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>.>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<.......<<<.....>>>......>>>>.......<<<.......<<<<<<<<<........>>>>>>>>>........>>>..........<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<..<<<<<<<<<<.....<<<<<<<.....>>>>>>>..>>>>>>>..>>>.>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<<..<<<......>>>.....>>>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<......>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<.....<<<<<....>>>>>...>>>....))).]<<<<<.<<<<<<<.<<..<<<<...<<<<<<<<<<......<<........>>..........<<<<<<<........<<<.......<<<<<....>>>>>....>>>....<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<.........>>>>>>>.....<<<<<....>>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>....>>>>>>>......<....<<<<<<<........>>>>>>>....>......>>>>.....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<..<<<<<....<<<<<<.<<<..<<....>>.>>>>>>>>>...>>>>>..>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>...... .....((((..[..[[..)))).((....((((....(((((((....(...(((..(((..((..(((((....)))))..)))))......((........(((..((..((...(..(((..(.((.....((((((....))))))......)).)......((((((...()...)))))).....(.((((....)))).)..)))..)..))))..))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...)))).)).(((((............))))).((((....))))...)))..).).....(.(((...(((((....)))).))))).)).))))....((((........((.....)).......))))..(.(..(((...(....(((.((((........)))).)).)...)....)))...)....).((((([[[...(((((.....((.]]])).......))))))))))..))))...))..........((([[...(.((((...(((.((((.(..((((((.((......(((((((.....)))))))...)).))))..)).).))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))))).)))..))))...))))....(.((((...((...((((.........))))...)))))).)......{...((((((..((((((((((......))))))))))...((..]])).....)))))))))).(((.......(((....))).....)))....]]..](.(((.(((.(((..(.....(...((((((.(..(.....((........))...........((((.........(.((.(......(..(....)...)..).))..)...((.(((...((((((.(....((.((((((....)))...(((......)))...))).)).....((.(.(((((.............)))))..(..(.(........).).....)..).)).....).).)))...)).)))))......))))....)...))))))).(...(.(((((.....(((..((...(((....)))...))....)))....))))).)......(....(((((((........)))))))....)..)...)........(((((((.(.....)..)))))))......)....))).))))))..)..(.(..((.(.((((.(.(..((((((..(((((....((((((.(....((....))...)))))))...)))))..))))))...)).))))..).))...)..)..(((((((((....)))))))))}..... 70S ribosome with EF-G, A/P- and P/E-site tRNAs in spectinomycin-treated Mycoplasma pneumoniae cells; 16S ribosomal RNA 7pib 7 76 4.7 RF00005 URS000054164D_272634 36171285 0030533 0006412 272634 ggucuuguagcucagucgguagagcaacggucugaagaaccgugugucggcaguucgauucugcccgagaccacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((.(..((.(........).)).(((((.......))))).....(((((.......)))))).))))).... 70S ribosome with EF-G, A/P- and P/E-site tRNAs in spectinomycin-treated Mycoplasma pneumoniae cells; tRNA-Phe 7pib 8 76 4.7 RF00005 URS000054164D_272634 36171285 0030533 0006412 272634 ggucuuguagcucagucgguagagcaacggucugaagaaccgugugucggcaguucgauucugcccgagaccacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((.(..((.(........).)).(((((.......))))).....(((((.......)))))).))))).... 70S ribosome with EF-G, A/P- and P/E-site tRNAs in spectinomycin-treated Mycoplasma pneumoniae cells; tRNA-Phe 7pic 3 2878 9.1 RF02540,RF02541 URS0000AB9B3C_272634 36171285 0003735 0005840 272634 aguuacuaagggcuuaugguggaugccuuggcacuaauaggcgaugaaggacguguuaaccugcgauaagcuucggguaggugguaagaaccucagauccggagauuuccgaauggagcaauccgguaguuggaaacagcuaucauuaauugaugaauaaauagucaauuaaagcaauacguggugaagugaaacaucucaguagccacaggaaaagaaaacgaaugugauuccguguguaguggcgagcgaaagcggaacaggccaaacuuaucauuagauagggguuguagggcuugcaauguggacuugaaaacgauagaagaagcuguuggaaagcagcgcgcaaaagggugauagccccguauuugaaauuguuuucauaccuagcgagaucccugaguagcucggaaaacguuauuuugagugaaucugcccagaccauuggguaagccuaaauacuaauuagugaccgauagcgaaacaguaccgugagggaaaggugaaaagaacccagagaugggagugaaauagauucugaaaccauaugccuacaacgugucagagcacauuaaugugugauggcgugcguuuugaaguaugagccggcgaguuaugauagcaagcguuaguuaaccaggagauggggagcuguagcgaaagcgaguuuuaaaagagcguuuguuuguuauuauagacccgaaacggguugagcuagucaugagcagguugaagguugaguaacaucaacuggaggaccgaaccgacucucguugaaacgauagcggaugacuugugauuaggggugaaauuccaaucgaaauccgugauagcugguucucgucgaaauagcuuuaaggcuagcgugagaucacaaauaaguggagguaaagcuacugaauguaugauggcgccggcguacugaauacaauuaaacucugaaugccauuuauuuuauucucgcagucagacagugggggauaagcuucauugucaagaggggaagagcccagaucauuaaauaagguccccaaaauauacuaaguggaaaaggaugugaaagugcuaaaacagcaaggauguuggcuuagaagcagccaucguuuaaagagugcguaacagcucacuugucgaguguuuuugcgccgaagauguaacggggcuaaguauauuaccgaauuuauggauaagauuuauaucuugugguagacgagcguuguauuggaguugaagucaaagcgugagcauugguggauccaauacaagugagaaugccggcaugaguaacgcuugggagugagaaucucccaaaccgauugacuaagguuuccuggaccagggucguccuuccaggguuagucuggaccuaagcugaggcugaaaagcguaggcgauggacaacagguuaauauuccuguacuuacaguuagacugauggagugacaaagaagguuuuccacccccauaauuggauuuggggauaaaucauaaggugguacaauaggcaaauccguugugcauaacauugagugaugaugucgagugaaaguagcgaaggugguauuaaucaugcuuucaagaaaagcuucuaggguuaaucuagcuguaaccaguaccgagaacgaacacacguagucaaggagaggauccuaagguuagcgagugaacuauagccaaggaacucugcaaauuaaccccguaaguuagcgagaaggggugcuuauguaaaaguaagccgcagugaagaacgaggggggacuguuuaacuaaaacacaacucuaugccaaaccguaaggugauguauauggggugacaccugcccagugcuggaagguuaaagaaggagguuagcgcaagcgaagcuuuuaacugaagccccagugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuagucggguaaauuccgucccgcuugaaugguguaaccaucucuugacugucucggcuauagacucggugaaauccagguacgggugaagacacccguuaggcgcaacgggacggaaagaccccgugaagcuuuacuguagcuuaauauugaucaggacauuaucauguagagaauagguaggagcaaucgaugcaaguucgcuaggacuuguugaugcgaaagguggaauacuacccuugguugugugcuguucuaauugguaacuguuauccaguuucaagacaguguuaggugggcaguuugacuggggcggucgccuccuaaaagguaacggaggcguacaaagguaccuucaguacgguuggaaaucguauguagaguguaaugguguaagggugcuugacugugagacauacaggucgaacaggugagaaaucaggucauagugauccggugguccaguauggaauggccaucgcucaacggauaaaagcuacuccggggauaacaggcugauacugcccaagaguucauaucgacggcaguguuuggcaccucgaugucgacucaucucauccucgagcugaagcagguucgaaggguucggcuguucgccgauuaaagagauacgugaguuggguucaaaccgucgugagacagguuggucccuaucuauugugcccguaggaagauugaagaguguugcuucuaguacgagaggaccgaagcgaggacaccucuuaugcuccaguuguagcgccagcugcaccgcuggguaguaacgugucuauuagauaaacgcugaaagcaucuaagugugaaacuaucucaaagauuaaucuucccauuucgcaagaaaguaagagccgucaaagacgaugacguugauagguuacagguguaagcauagugauauguugagcugaguaauacuaauugcucgaggacu .<.......<<<<.<<<<<<....<<<..<<<<<<<<<<<<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>....<<<<<<...<.<......>....>.>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<.....<<<<......>>>>.......<<<<<<<<<.....<<...<<<<<<<<<<.<<.....<<<<......>>>>.((......<<<.....))>>>...>>....>>>>>>>>>>..>>..>>>>>..>>>>.....<<<<<<<<.......>>>>>>>>.......<<<<..((((>>>>...>>>......>>.>>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>.............>....>>>>>>.>>>>.......<<<<..<<<<......>>>>..>>>>...<<..........>>.<<<<<<....<<<<<<<<<<<<<...<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....>>>>>>>>>>>>>..<<.<...<<<<.......<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<.<<........>>.>>>>>....>>>>>>>>>...<<.......>>........>>>>......>.>>..<<<<<<....<<<<<....>>>>>..<<<<<<....<<<<<<<<<......<<<....<<..<<<.....<.<<<..>>>..>.....>>>..>>..>>.>......>>>>>>>>>...>>>>>>.....<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<....>>>>>>>....>>>>>><<<<<<<<<<<<......<<<<<.<<....>>.>>>>>...>>>>>>>>>>.>>.....>>>>>>.......((..<<<<<<<.......>>>>>>>((.....((.[..((...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<.<<<<<<..[....<<<....((.(...<<<..<<<<<<<<<....<<<...>>>>><<..<<<<<..<<<<<<<<<<<.<<.....>>>>>>>>>....>>>>..>>>>>...>><................>>>>>....>>>.....))).........>>>...].......>>>>>>.>>>>>>>..)).....<<......>>.].)).<<<<.....>>>>...))...<<<<<...<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<......>>>>>>.............<<<<<<<<...<<.........>>...<<<<<<<.....<<<....>>>.......>>>>>>>..<<<<.<<<..<<<<<<<..<<<...<<...<.<<<<.<<....>>..>>>>.>...>>...>>>>>>>>..>>>>><<<<<.........>>>>>........<...........<.<<<<.....>>>>.>.....>....>>>>...>>.>>>>>>......>>.>>>>>>>>>>>>>))...........<<<<<........>>>>>..<<<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<.<<<.<<<<..<<............<<<<<..<<........<<<<..........>>>>.....>>.............>>>>>...>>..>>>>.>>>.>>...<<<..<<<<<.....>>>>>.>>>....>>>>>>>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<....<<<<<<...<<<<<<.......>>>>>>..........(((......>>>>>>....<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>........<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>.....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>>>....<<<<<<<....(((..<<<<<<<...............>>>>>>><<<<<<...<<<<...<<<<<<<<<<<.>>>>>>>>>..>>>>>...>>>>.>>>>>>..<<<....<<<<.............>>>>....>>>.)))........>>>>>>>..................<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>.....>. ..........(((.(((((.....(((..(((((((..((((......((((((.[..[[[.))).....((((((...(((]]]...])))......))))))...)))....(((....)))(.(((.((....)).))).).(((((((((.........))))))))).))....((((((.....(...[..)......))))).).........((....))...(((((.....(..]....)....)))))...((((...(((((......)))))......((((.((((.....(....(((((((.((..((...(((((......)))))[[......(((.....]])))....))...)).)))))))...)..))))...)))))....(((((.((..[....)).))))).......((((]..[..))))...)))......))...))))).))...............((....))....)).........((((....)))).............).....))))).)))......(.(.((...(((..[...)))...)).).<.(............).((((((....(((((((((((.(....(....(((.....)))....)....((....))..(.(.......).)....).)))))))))))..((.(...(((..(.....(.(((..(((.(((.....(((((......))))).....<)))...(((.((.((........)).)))))..).))..))).).(.((.......))...)..)..)))......).))..(((..(....(((((....))))).(..((((......((.(...(.....(.(....(((.(.(.....(...........).....).).)))...).)......)...))).....))))...)...((((.((..(......)..)).))))....(((......)))....(((.(((...((([[[...(.(((((.....(.....((..(...(.(..(.....{..((((.(.(..(((.........)))..).).....(...((......)).).))))....)..).)...).))...........]]].)...))))).))))...)))))).(((((((....)))))))....)..)))(.(((((..((.........(((.((....))])).).....))..)))))..).....)))))).......((...((((((.......)))))).(.(....(.....((..(((((((...((.....)).))))))....[[((((.((...((....(((....)))....))...))...(((((........)))))]]....(..((..((....((((...(((....(((..((.((((((.....{....)))))((..(((((...((((((((((.((.....)))))))))....)))...)))))...))(..((.......))...)).))....))).....)))(..)....))))...)).......))..)....)))).))).....((......))....).((((.....))))..)..)..((((....((((((((.((.......(.......(((((....(.[..).....)))))(((((........)))))(...).......(.((.(.((.>.((.........))...((((.((.....(((....))).......)).)))).]((((.(((..((.((((..(((...((.....((...((....))....)).....))...)))))))...)))))(((((.........)))))........((..........(.(((.......))).)..)..)....))))...))..).)).).)...)).)))))))).))))))......).[..(((((.....>].)))).).((((((....((.((......((((.((((((..(((((..(((((.(..((.(.(.(((...((..(......[..(((((..(((.......((((.(.......)))))....)))...........].))))))..))...))).).).))...(((..(((((.....))))).))).....).)))))...)))))..(((......[)))(((((((........)]))))))([((....(.(((..(.(((((.........)))))...)...][.[[[.......))).)....((((..(((...{..)))..)))).(((....))).))]]].].....(.((((..((....]...)).))).)).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......(.((.((((((..((((((.(........).)))..))).((.((.....).))).....)))))..)...))..).....(((((((....))).))))....))..))...))))))[...(((((((....(((..(.(((((.....(....)....))))).).(((((...((((...((((.((((((..}.))))))...))))...)))).)))))...(((....((.(.....}.......).))....))).)))...]....)))))))(.................(((((((((.......)))))....(((.((((..((....(((((....)))))...))...))))..)))...))))...)... 70S ribosome with P/E-site tRNA in spectinomycin-treated Mycoplasma pneumoniae cells; 23S ribosomal RNA 7pic 4 105 9.1 RF00001 URS000000E851_272634 36171285 0003735 0005840 272634 uuuggugcccaugucgcuguggaaacaccugguuccauuucgaacccagcaguuaagcacaguggagccgaauguagcugcagugagaauaggaaagcaccaagc .<<<<<<<.....<<<<<<<<.....<<<<<<.............>>>>..>>....>>>>>>.>>.<<.....<...........>....>>...>>>>>>>.. .(((((((.....((((((((.....((((((...(.....)...))))..))....)))))).))..............................))))))).. 70S ribosome with P/E-site tRNA in spectinomycin-treated Mycoplasma pneumoniae cells; 5S ribosomal RNA 7pic 5 1493 9.1 RF00177,RF01959,RF01960 URS00019B76CF_272634 36171285 0003735 0005840 272634 ucugagaguuugauccuggcucaggauuaacgcuggcggcaugccuaauacaugcaagucgaucgaaaguaguaauacuuuagaggcgaacgggugaguaacacguauccaaucuaccuuauaaugggggauaacuaguugaaagacuagcuaauaccgcauaagaacuuugguucgaaucaaaguugaaaggaccugcaaggguucguuauuugaugagggugcgccauaucagcuaguuggugggguaacggccuaccaaggcaaugacguguagcuaugcugagaaguagaauagccacaaugggacugagacacggcccauacuccuacgggaggcagcaguagggaauuuuucacaaugagcgaaagcuugauggagcaaugccgcgugaacgaugaaggucuuuaagauuguaaaguucuuuuauuugggaagaaugacuuuagcagguaauggcuagaguuugacuguaccauuuugaauaagugacgacuaacuaugugccagcagucgcgguaauacauaggucgcaagcguuauccggauuuauugggcguaaagcaagcgcaggcggauugaaaagucugguguuaaaggcagcugcuuaacaguuguaugcauuggaaacuauuaaucuagagugugguagggaguuuuggaauuucauguggagcggugaaaugcguagauauaugaaggaacaccaguggcgaaggcgaaaacuuaggccauuacugacgcuuaggcuugaaaguguggggagcaaauaggauuagauacccuaguaguccacaccguaaacgauagauacuagcugucggggcgauccccucgguagugaaguuaacacauuaaguaucucgccuggguaguacauucgcaagaaugaaacucaaacggaauugacggggacccgcacaagugguggagcauguugcuuaauucgacgguacacgaaaaaccuuaccuagacuugacauccuuggcaaaguuauggaaacauaaugccgagugacagguggugcaugguugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuuaucguuaguuacauugucuagcgagacugcuaaugcaaauuggaggaaggaagggaugacgucaaaucaucaugccccuuaugucuagggcugcaaacgugcuacaauggccaauacaaacagucgccagcuuguaaaagugagcaaaucuguaaaguuggucucaguucggauugagggcugcaauucguccucaugaagucggaaucacuaguaaucgcgaaucagcuaugucgcggugaauacguucucgggucuuguacacaccgcccgucaaacuaugaaagcugguaauauuuaaaaacguguugcuaaccauuaggaagcgcaugucaaggauagcaccggugauuggaguuaagucguaacaagguaccccuacgagaacguggggguggauca .....<<<<....(((..>>>>.<<<...<<<<..<<<<<<<<......<<..<<..<<<..<<.<<<<<<....>>>>>>.>>>>>......<<........<<<.<....<<...<..<<<..<.<<..<..<<<<<<....>>>>>>.....>>>.>.....<<<<<<<<......>>>>>>>>....<<<<<<....>>>>>>.>.>>..>..>>..>.>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<............>>>>>.<<<<....>>>>...>>.>>..........<<<...<.<<<....>>>..>>>>..>>.>>>>>>..<<<<.......<<<.....>>>......>>>>...<...<<<.........<<<<<<<........>>>>>>>..........>>>....>......<<<<(((...<<<<<......<.)))>........>>>>>>>>>...>>>>..>>>..........<<<((.....<<<<...<<<.<<<<<<..<<<<<<<<<<.....<<<<<<<.....>>>>>>>..>>>>>>>>..>>.>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<<..<<<......>>>.....>>>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<......>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<.....<<<<<....>>>>>...>>>....)))...<<<<.<<<<<<<.<<..<<<<...<<<<<<<.<<......<<........>>..........<<<<<<<......<.<<<........<<........>>.....>>>.>..<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<.........>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>..>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>....>>>>>>>...........<<<<<<<........>>>>>>>...........>>>>......<<<<<<..........>>>>>>.......>>...>>>>>>>>>>.>........<<.<.<<<<.<<<..<<<<<...<<<<<....<<<<<<.<<<..<<....>>.>>>>>>>>>...>>>>>...>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>...... .....(((......[[...)))..(((..((((..((((((.((.............(((..((.((.((......)).)).))))).......((.......(((......((...(..((.(((.((.....((((((....))))))......)).).....(..((((...()...))))..)....(.((((....)))).))).))..)..))....))).((.....((...(((((.((.......)).))))).)).......))..((((((((....))))...))))))...((((............))))..((((....))).)..........)....(.(((...(..((....))...))))).)..))))))..((((........((.....)).......))))...(...(((...(.....((.((((........)))).)).....)....)))......)...(.((([[[...(((((.....((.]]])).......)))))))).)..))).))).)..........((([[...(.((((...(((.((((.(..(((((((((.......((.(((.....))).))....)))))))..)).).))))..((((.((((....(((((((...(((((.((...((........))......)).)))))...).......((....)).))))))...))))..)))..))))...))))....((((((....(...((((.........))))...).))))))......{...((((((...((((((.((......)).))))))....((..]])).....))))))))))..((.......(((....))).....).)....]]...((.((.(((((((..(..(((....((((...(........((........))..........((((.(...(...(..((((......(.((....)).)...))))...)).((.((....((.(((.(....((((((.((....))....(((......)))...)))))).....((.(.(((((.(.........).)))))..(..(.(((....))).).....)..).)).....).).))....))..)))).....).)))).......)..)))).(...(((((((.....(((..(((.(((......)))).))....)))....)))))))......(....(((((.(........).)))))....)..)....))).....(((((((.(.....)..)))))))......)....)))))))))..))..(.(...(.(.((((.(.(...((((....((((....((..(.((((..((....)).)))))..))...))))....))))...).).))))..).)....)..)..(((((.(((....))).)))))}..... 70S ribosome with P/E-site tRNA in spectinomycin-treated Mycoplasma pneumoniae cells; 16S ribosomal RNA 7pic 8 76 9.1 RF00005 URS000054164D_272634 36171285 0030533 0006412 272634 ggucuuguagcucagucgguagagcaacggucugaagaaccgugugucggcaguucgauucugcccgagaccacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((.(..(((..........)))..((((.......))))......(((...........)))).))))).... 70S ribosome with P/E-site tRNA in spectinomycin-treated Mycoplasma pneumoniae cells; tRNA-Phe 7pio 3 2878 9.5 RF02540,RF02541 URS0000AB9B3C_272634 36171285 0003735 0005840 272634 aguuacuaagggcuuaugguggaugccuuggcacuaauaggcgaugaaggacguguuaaccugcgauaagcuucggguaggugguaagaaccucagauccggagauuuccgaauggagcaauccgguaguuggaaacagcuaucauuaauugaugaauaaauagucaauuaaagcaauacguggugaagugaaacaucucaguagccacaggaaaagaaaacgaaugugauuccguguguaguggcgagcgaaagcggaacaggccaaacuuaucauuagauagggguuguagggcuugcaauguggacuugaaaacgauagaagaagcuguuggaaagcagcgcgcaaaagggugauagccccguauuugaaauuguuuucauaccuagcgagaucccugaguagcucggaaaacguuauuuugagugaaucugcccagaccauuggguaagccuaaauacuaauuagugaccgauagcgaaacaguaccgugagggaaaggugaaaagaacccagagaugggagugaaauagauucugaaaccauaugccuacaacgugucagagcacauuaaugugugauggcgugcguuuugaaguaugagccggcgaguuaugauagcaagcguuaguuaaccaggagauggggagcuguagcgaaagcgaguuuuaaaagagcguuuguuuguuauuauagacccgaaacggguugagcuagucaugagcagguugaagguugaguaacaucaacuggaggaccgaaccgacucucguugaaacgauagcggaugacuugugauuaggggugaaauuccaaucgaaauccgugauagcugguucucgucgaaauagcuuuaaggcuagcgugagaucacaaauaaguggagguaaagcuacugaauguaugauggcgccggcguacugaauacaauuaaacucugaaugccauuuauuuuauucucgcagucagacagugggggauaagcuucauugucaagaggggaagagcccagaucauuaaauaagguccccaaaauauacuaaguggaaaaggaugugaaagugcuaaaacagcaaggauguuggcuuagaagcagccaucguuuaaagagugcguaacagcucacuugucgaguguuuuugcgccgaagauguaacggggcuaaguauauuaccgaauuuauggauaagauuuauaucuugugguagacgagcguuguauuggaguugaagucaaagcgugagcauugguggauccaauacaagugagaaugccggcaugaguaacgcuugggagugagaaucucccaaaccgauugacuaagguuuccuggaccagggucguccuuccaggguuagucuggaccuaagcugaggcugaaaagcguaggcgauggacaacagguuaauauuccuguacuuacaguuagacugauggagugacaaagaagguuuuccacccccauaauuggauuuggggauaaaucauaaggugguacaauaggcaaauccguugugcauaacauugagugaugaugucgagugaaaguagcgaaggugguauuaaucaugcuuucaagaaaagcuucuaggguuaaucuagcuguaaccaguaccgagaacgaacacacguagucaaggagaggauccuaagguuagcgagugaacuauagccaaggaacucugcaaauuaaccccguaaguuagcgagaaggggugcuuauguaaaaguaagccgcagugaagaacgaggggggacuguuuaacuaaaacacaacucuaugccaaaccguaaggugauguauauggggugacaccugcccagugcuggaagguuaaagaaggagguuagcgcaagcgaagcuuuuaacugaagccccagugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuagucggguaaauuccgucccgcuugaaugguguaaccaucucuugacugucucggcuauagacucggugaaauccagguacgggugaagacacccguuaggcgcaacgggacggaaagaccccgugaagcuuuacuguagcuuaauauugaucaggacauuaucauguagagaauagguaggagcaaucgaugcaaguucgcuaggacuuguugaugcgaaagguggaauacuacccuugguugugugcuguucuaauugguaacuguuauccaguuucaagacaguguuaggugggcaguuugacuggggcggucgccuccuaaaagguaacggaggcguacaaagguaccuucaguacgguuggaaaucguauguagaguguaaugguguaagggugcuugacugugagacauacaggucgaacaggugagaaaucaggucauagugauccggugguccaguauggaauggccaucgcucaacggauaaaagcuacuccggggauaacaggcugauacugcccaagaguucauaucgacggcaguguuuggcaccucgaugucgacucaucucauccucgagcugaagcagguucgaaggguucggcuguucgccgauuaaagagauacgugaguuggguucaaaccgucgugagacagguuggucccuaucuauugugcccguaggaagauugaagaguguugcuucuaguacgagaggaccgaagcgaggacaccucuuaugcuccaguuguagcgccagcugcaccgcuggguaguaacgugucuauuagauaaacgcugaaagcaucuaagugugaaacuaucucaaagauuaaucuucccauuucgcaagaaaguaagagccgucaaagacgaugacguugauagguuacagguguaagcauagugauauguugagcugaguaauacuaauugcucgaggacu .........<<<<.<<<<<<....<<<..<<<<<<<<<<.<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>..<<<<<<<<.........>>>>>>>>..>>....<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<....<<<<<<....>>>>>>......<<<<<<<<<.....<<...<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>..>>..>>>>>..>>>>.....<<<<<<<<.......>>>>>>>>.......<<<<..((((>>>>...>>>.......>.>>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>.............>....>>>>>>.>>>>.......<<<<..<<<<......>>>>..>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<...<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<.<<........>>.>>>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<....<<<<<<<<<<......<<....<<..<<<<<...<.<<<..>>>..>...>>>>>..>>..>>.......>>>>>>>>>>...>>>>>>.>>..<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((....<<<<<<...........<<..<<<<<<<<<........<<.<<.<<...<<<.........>>>...>>.........<<......>>...>>.>>....>>>>>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<....>>>>>>>....>>>>>><<<<<<<<<<<<.......<<<<.<<....>>.>>>>....>>>>>>>>>>.>>.....>>>>>>.......<<...<<<<<<.......>>>>>><<<<....<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<.<...<<<<<...<<<<...<<<..<<<<<<<<<....[[[...>>>>><<..<<<<<..<<<<<<<<<<<.<<.....>>>>>>>>>....>>>>..>>>>>...>><..<<.......>>...>>>>>....>>>....>>>>........>>>>>..>......>>>>>>>>>>>>>>>..>>.....<<......>>.>>>>.<<<<.....>>>>..>>>>..<<<<<...<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<......>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<..<<<<<<<.<<....>>..>>>>>>>..>>...>>>>>>>>..>>>>><<<<<.........>>>>>........<...........<.<<<<.....>>>>.>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>>>>>>>>...........<<<<<........>>>>>..<<<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<..<<.<<<.<<<<..<<<...........<<<<<..<<<......<<<<<<<......>>>>>>>...>>>.............>>>>>..>>>..>>>>.>>>.>>...<<<..<<<<<.....>>>>>.>>>.....>>>>>>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>..........(((......>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<..<<<<<<<...<<.......>>...>>>>>>>...>>>.>.......<.<<<..<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>......>>>..>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>>>....<<<<<<<....<<<...<<<<<<...............>>>>>>.<<<<<<...<<<<...<<<<<<<<<<<.]]]>>>>>>..>>>>>...>>>>.>>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>........>>>>>>>..................<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....... ..........(((.(((((.....(((..(((((((((((((......(((((.....[[[..)).....((.(((...(((]]]....)))......))).))...)))....(((....)))(((((.((....)).)))))..((((((((.........))))))))..))....((((((.....(...[..)......))))).).........((....))...(((((.....(..]....)....)))))...((((...(((((......)))))......((((((.((......(...(((((((.((.(((...(((((......)))))[[......(((.....]])))...)))...).))))))))..)...)).))..)))))....(((((.(((....).)).))))).......((((..[[[[))))...)))......)).))))))).))...............((....))....))......(..((((....))))............)).....))))).)))......(.(.((...(((..[...)))...)).).<.(............).((((((....(((((((.(((.(....(....(((.....)))....)....((....))..(.((.....)).)....).))).)))))))..((.(...((((((.....(.((((((((.((((...((((((......))))))...)<)))...(((.((.((........)).)))))..).))))))).).(.((.......))...)..))))))......).))..((((.(....(((((....)))))(((.((((....((((((((((......((....(((.((((....(.((.().))..)....)))).)))..)).......))))))))))...)))).).))..(((((((..(......)..)))))))....(((......)))....(((.(((...((([[[....(.((((.....(.....((..(..((((.((.....{.(((((.(.(..(((.........)))..).).....(...((......)).).)))).)..)).))))..).))...........]]].)...))))..))))...)))))).(((((((....)))))))....).))))(((((((..(((........((..((....))].)).....)))..))))).)).....)))))).......((...((((((.......))))))..((....(((...((..((((((....((.....))..)))))....[[((((.((...((....(((....)))....))...))...(((((........)))))]]((((.(.(((((....(.((....((((..(..(...((((((((.....{{...)))))(...((((...((((((((((..((.....)).))))))....))))...))))....)(..((.......))...))).).....).)...))))(..).....)).)...).....))))..))))))))).))).....((......))..))).((((.....))))..))....((((....((((((((.((..(....(.......(((((....(.[..).....)))))((((((......))))))(...).......(.((.(.((.>.((.........))...((((.((.....(((....))).......)).)))).]((((.(((..((.((((..((....((....((((..((....))...))))....))....))))))...)))))(((((.........)))))........((..........(.(((.......))).)..)..)....))))...))..).)).).)..))).)))))))).))))))......).[..(((((.....>].)))))..(((((((..(((.((......((((.((((((..((((..((((((((..((.(((.(((...(((.(......[..(((((..(((.......((((.(......).))))....)))...........].)))))).)))...))).))).))...(((..(((((.....))))).))).....))))))))...))))..(((......[)))((((((..........]))))))(.((....(((((..(.(((((.........)))))...)......[[[.......)))))....((((..(((...{..)))..)))).(((....))).))]]].......((.(((..((..]]]]..)).))).)).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(((((((....))).))))....))..))).)))))))[...(((((((....(((..(.(((((.....(....)....))))).).(((((...(((....(((((((((((.}}.))))))..)))))....))).)))))...(((....((.(.....}.......).))....))).)))...]....)))))))(.................(((((((((.......)))))....(((.((((.(((....(((((....)))))...)))..))))..)))...))))...)... 70S ribosome with P-site tRNA in pseudouridimycin-treated Mycoplasma pneumoniae cells; 23S ribosomal RNA 7pio 4 105 9.5 RF00001 URS000000E851_272634 36171285 0003735 0005840 272634 uuuggugcccaugucgcuguggaaacaccugguuccauuucgaacccagcaguuaagcacaguggagccgaauguagcugcagugagaauaggaaagcaccaagc <<<<<<<<.....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<.......<<....>>.......>>...>>>>>>>>. .(((((((.....((.(((((.....((((((...(.....)...))))..))....)))))..))..(.......(......).......)....)))))).). 70S ribosome with P-site tRNA in pseudouridimycin-treated Mycoplasma pneumoniae cells; 5S ribosomal RNA 7pio 5 1493 9.5 RF00177,RF01959,RF01960 URS00019B76CF_272634 36171285 0003735 0005840 272634 ucugagaguuugauccuggcucaggauuaacgcuggcggcaugccuaauacaugcaagucgaucgaaaguaguaauacuuuagaggcgaacgggugaguaacacguauccaaucuaccuuauaaugggggauaacuaguugaaagacuagcuaauaccgcauaagaacuuugguucgaaucaaaguugaaaggaccugcaaggguucguuauuugaugagggugcgccauaucagcuaguuggugggguaacggccuaccaaggcaaugacguguagcuaugcugagaaguagaauagccacaaugggacugagacacggcccauacuccuacgggaggcagcaguagggaauuuuucacaaugagcgaaagcuugauggagcaaugccgcgugaacgaugaaggucuuuaagauuguaaaguucuuuuauuugggaagaaugacuuuagcagguaauggcuagaguuugacuguaccauuuugaauaagugacgacuaacuaugugccagcagucgcgguaauacauaggucgcaagcguuauccggauuuauugggcguaaagcaagcgcaggcggauugaaaagucugguguuaaaggcagcugcuuaacaguuguaugcauuggaaacuauuaaucuagagugugguagggaguuuuggaauuucauguggagcggugaaaugcguagauauaugaaggaacaccaguggcgaaggcgaaaacuuaggccauuacugacgcuuaggcuugaaaguguggggagcaaauaggauuagauacccuaguaguccacaccguaaacgauagauacuagcugucggggcgauccccucgguagugaaguuaacacauuaaguaucucgccuggguaguacauucgcaagaaugaaacucaaacggaauugacggggacccgcacaagugguggagcauguugcuuaauucgacgguacacgaaaaaccuuaccuagacuugacauccuuggcaaaguuauggaaacauaaugccgagugacagguggugcaugguugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuuaucguuaguuacauugucuagcgagacugcuaaugcaaauuggaggaaggaagggaugacgucaaaucaucaugccccuuaugucuagggcugcaaacgugcuacaauggccaauacaaacagucgccagcuuguaaaagugagcaaaucuguaaaguuggucucaguucggauugagggcugcaauucguccucaugaagucggaaucacuaguaaucgcgaaucagcuaugucgcggugaauacguucucgggucuuguacacaccgcccgucaaacuaugaaagcugguaauauuuaaaaacguguugcuaaccauuaggaagcgcaugucaaggauagcaccggugauuggaguuaagucguaacaagguaccccuacgagaacguggggguggauca .....<<<<..[.((([.>>>>.<<<<.<<<<<..<<<<<<<<......<<.<<<..<<<..<<.<<<<<<....>>>>>>.>>>>>......<<........<<<.<<<..<<...<...<<<<<.<<.....<<<<<<....>>>>>>......>>.>.....<<<<<<<<......>>>>>>>>....<<<<<<....>>>>>>>>>>...>..>>>>>.>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>...>>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>..........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<.......<<<.....>>>......>>>>...<...<<<.........<<<<<<<........>>>>>>>..........>>>....>.....<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<..<<<<<<<<<<.....<<<<<<<.....>>>>>>>..>>>>>>>>..>>.>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<<..<<<......>>>.....>>>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<.<<<<<......>>>>>.>>>>...<<..))>>.....>>>>>>.>>>.<<<<....<<<<<....>>>>>..>>>>..].))).]<<<<<.<<<<<<<.<<..<<<<<..<.<<<<<<........<<........>>..........<<<<<<<......<<<<<<.....<<<<<<....>>>>>>..>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<.........>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>......>>>>>>.>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>.....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<..<<<<<....<<<<<.<<<<..<<....>>.>>>>>>>>>...>>>>>..>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .....((((..[..[[..)))).(((..((...(.(((((((((......(......(.(..((.((((((....)))))).))).)......(((.......((..(((.......(...(((.(.((.....(((((......)))))......)).).....(((((((........)))))))....(.((((....)))).).)))...)....)))..)).(((....((...(((((.((.......)).))))).))......)))..((((((((....))))...))))))).(((((............))))).((((....))))......)...).....(.(((...(.(((....)))..))))).)).))))))..((((......((((.....)))).....))))....(..((....(...(.((.(((..........))).))..)..).....))...)......(.((([[[...(((((.....((.]]])).......)))))))).)..)..)).)))..........((([[...(.((((...(((.((((.(..((.(.(.((.......((.(((.....))).))....)).).)...)).).))))..((((.((((...((((((((....(((((.(...((........))......).)))))....).......((....)).)))))))..))))..)))..))))...))))....((((((...(....((((.........))))....)))))))......{...((((((..(((..(((.(.......))))..)))...((..]])).....)))))))))).(.(.......(((....))).....).)....]]..](((((.((((.((.((..((..(....((((((..(.....((........))..........(((((((......((.((((......(.((....))..)..))))..))..((.(((...((.(((.(....((((((.((....))....(((......)))...)))))).....((((.(((((.(.........).)))))..(..(.(((....))).).....)..)))).....).).))....)).)))))....)))))))...)..))))))...(...(.((((......(((..(((..(((....))).).))....))).....)))).)......(....(((((.(........).)))))....)..)..)..)).....(.(((((..........))))).)......))...)).))))))).))..(.(..((.(..(((.(((..((..((..((((......(.((..(((..((....)).))).)).).....))))..).).))..))).)))...).))...)..)..(((((((((....)))))))))}..... 70S ribosome with P-site tRNA in pseudouridimycin-treated Mycoplasma pneumoniae cells; 16S ribosomal RNA 7pio 7 76 9.5 RF00005 URS000054164D_272634 36171285 0030533 0006412 272634 ggucuuguagcucagucgguagagcaacggucugaagaaccgugugucggcaguucgauucugcccgagaccacca <<<<<<...<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>.>>>>>>.... (((.(((..((((........))))..((((.......))))......(((((.......)))))))).))).... 70S ribosome with P-site tRNA in pseudouridimycin-treated Mycoplasma pneumoniae cells; tRNA-Phe 7pip 3 2878 9.3 RF02540,RF02541 URS0000AB9B3C_272634 36171285 0003735 0005840 272634 aguuacuaagggcuuaugguggaugccuuggcacuaauaggcgaugaaggacguguuaaccugcgauaagcuucggguaggugguaagaaccucagauccggagauuuccgaauggagcaauccgguaguuggaaacagcuaucauuaauugaugaauaaauagucaauuaaagcaauacguggugaagugaaacaucucaguagccacaggaaaagaaaacgaaugugauuccguguguaguggcgagcgaaagcggaacaggccaaacuuaucauuagauagggguuguagggcuugcaauguggacuugaaaacgauagaagaagcuguuggaaagcagcgcgcaaaagggugauagccccguauuugaaauuguuuucauaccuagcgagaucccugaguagcucggaaaacguuauuuugagugaaucugcccagaccauuggguaagccuaaauacuaauuagugaccgauagcgaaacaguaccgugagggaaaggugaaaagaacccagagaugggagugaaauagauucugaaaccauaugccuacaacgugucagagcacauuaaugugugauggcgugcguuuugaaguaugagccggcgaguuaugauagcaagcguuaguuaaccaggagauggggagcuguagcgaaagcgaguuuuaaaagagcguuuguuuguuauuauagacccgaaacggguugagcuagucaugagcagguugaagguugaguaacaucaacuggaggaccgaaccgacucucguugaaacgauagcggaugacuugugauuaggggugaaauuccaaucgaaauccgugauagcugguucucgucgaaauagcuuuaaggcuagcgugagaucacaaauaaguggagguaaagcuacugaauguaugauggcgccggcguacugaauacaauuaaacucugaaugccauuuauuuuauucucgcagucagacagugggggauaagcuucauugucaagaggggaagagcccagaucauuaaauaagguccccaaaauauacuaaguggaaaaggaugugaaagugcuaaaacagcaaggauguuggcuuagaagcagccaucguuuaaagagugcguaacagcucacuugucgaguguuuuugcgccgaagauguaacggggcuaaguauauuaccgaauuuauggauaagauuuauaucuugugguagacgagcguuguauuggaguugaagucaaagcgugagcauugguggauccaauacaagugagaaugccggcaugaguaacgcuugggagugagaaucucccaaaccgauugacuaagguuuccuggaccagggucguccuuccaggguuagucuggaccuaagcugaggcugaaaagcguaggcgauggacaacagguuaauauuccuguacuuacaguuagacugauggagugacaaagaagguuuuccacccccauaauuggauuuggggauaaaucauaaggugguacaauaggcaaauccguugugcauaacauugagugaugaugucgagugaaaguagcgaaggugguauuaaucaugcuuucaagaaaagcuucuaggguuaaucuagcuguaaccaguaccgagaacgaacacacguagucaaggagaggauccuaagguuagcgagugaacuauagccaaggaacucugcaaauuaaccccguaaguuagcgagaaggggugcuuauguaaaaguaagccgcagugaagaacgaggggggacuguuuaacuaaaacacaacucuaugccaaaccguaaggugauguauauggggugacaccugcccagugcuggaagguuaaagaaggagguuagcgcaagcgaagcuuuuaacugaagccccagugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuagucggguaaauuccgucccgcuugaaugguguaaccaucucuugacugucucggcuauagacucggugaaauccagguacgggugaagacacccguuaggcgcaacgggacggaaagaccccgugaagcuuuacuguagcuuaauauugaucaggacauuaucauguagagaauagguaggagcaaucgaugcaaguucgcuaggacuuguugaugcgaaagguggaauacuacccuugguugugugcuguucuaauugguaacuguuauccaguuucaagacaguguuaggugggcaguuugacuggggcggucgccuccuaaaagguaacggaggcguacaaagguaccuucaguacgguuggaaaucguauguagaguguaaugguguaagggugcuugacugugagacauacaggucgaacaggugagaaaucaggucauagugauccggugguccaguauggaauggccaucgcucaacggauaaaagcuacuccggggauaacaggcugauacugcccaagaguucauaucgacggcaguguuuggcaccucgaugucgacucaucucauccucgagcugaagcagguucgaaggguucggcuguucgccgauuaaagagauacgugaguuggguucaaaccgucgugagacagguuggucccuaucuauugugcccguaggaagauugaagaguguugcuucuaguacgagaggaccgaagcgaggacaccucuuaugcuccaguuguagcgccagcugcaccgcuggguaguaacgugucuauuagauaaacgcugaaagcaucuaagugugaaacuaucucaaagauuaaucuucccauuucgcaagaaaguaagagccgucaaagacgaugacguugauagguuacagguguaagcauagugauauguugagcugaguaauacuaauugcucgaggacu .<.......<<<<.<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>....<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((....<<<<<......>>>>>......<<<<<<<<<.....<<...<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>..>>..>>>>>..>>>>.....<<<<<<<<.......>>>>>>>>.......<<<<..<<<<>>>>...)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<....>>>>.............}....>>>>>>.>>>>.......<<<<..<<<<......>>>>..>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<...<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<.<<........>>.>>>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<....<<<<<<<<<<......<<....<<<.<<<<....<<..<<>>..>.>....>>>>.>>>..>>.......>>>>>>>>>>...>>>>>>.>>..<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>>.<<<<<<....>>>>>>.....>>>>>><<<<<<<<<<<<......<<<<<.<<....>>.>>>>>...>>>>>>>>>>.>>.....>>>>>>.......<<...<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<.<...<<<<<...<<<<...<<<..<<<<<<<<<....(((...>>>>><<..<<<<<..<<<<.<<<<<<.<<.....>>>>>>>>.....>>>>..>>>>>...>>...<<.......>>....>>>>....>>>....>>>>........>>>>>..>......>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<<...<<<<<<<<..................<<<<<...............>>>>><<<<<<......>>>>>>.............<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<..<<..<<<<<<..<<....>>...>>>>>>..>>..>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<.............<<<<.....>>>>.......>....>>>>>..>>.>>>>>>.........>>>>>>>>>>>>>>>...........<<<<<........>>>>>..<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<..<<<<<<<<<.<<.<<<.<<<..<<<<...........<<<<<..<<<......<<<<<<<......>>>>>>>...>>>.............>>>>>..>>>>..>>>.>>>.>>...<<<..<<<<<.....>>>>>.>>>....>>>>>>>>>...>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>..........(((......>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<.(((..>>>>..)))>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<<....<<<..<<<<<<<.....<....>....>>>>>>><<<<<<...<<<<...<<<<<<<<<<<.)))>>>>>>..>>>>>...>>>>.>>>>>><.<<<....<<<<<...........>>>>>....>>>>>>>........>>>>>>>..................<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>.....>. (........((((.((((((....(((..(((((((((((((......(((((.....[[[..)).....((((((...(((]]]....)))......))))))...)))....(((....)))(.((((((....)))))).)..((((((((.........))))))).).))....((((((.....(...[..)......))))).).........((....))...((((......(..]....).....))))...((((...(((((......)))))......(((((((((.....((...(((((((.((..((...(((((......)))))[[......(((.....]])))...))....)).)))))))..))..)))))..)))))....(((((.(((.[..).)).))))).......((((].[[[[))))...)))......)).))))))).))...............((....))....)).........((((....)))).............)....)))))).)))).....(.(.((...(((..[...)))...)).).<.(((........))).((((((....(((.(((.(((.(....((...(((.....)))...))....((....))..(.(.......).)....).))).))).)))..((.(...((((((.....((((((.(((.(((.....(((((......))))).....<)))...(((.((.((........)).)))))..).)).)))))).(.((.......))...)..))))))......).))..((((((....(((((....))))).((.((((....((((((((((.....(((....(.(...(((...(((......)..))..)))...).)..)).).....))))))))))...)))).).)...(((((((..(......)..)))))))....(((......)))...((....((...((([[[...(((((((.....(.....((..(..(((.(((.......(((((.(.(..(((.........)))..).).....(...((......)).).)))))...))).)))..).))...........]]].)...))))))))))...))...).).(((((....)))))......))))))(.(((((..(((........(((.((....))])).)....)))..)))))..).....))))))............((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((..((((...(((....)))...)))..)))...(((((........)))))]](((((((((((((...(.(((...((((..((((..(((((((((.....{{...)))))(...(((((..((((((((((..((.....)).))))))....))))..)))))....)...((.......))....))))....))))...))))(..)....))).)..)).....))))))))))))))).))).....((......)).)))).((((.....))))..))))..((((....((((((((..(..(....(.......(((((....(.[..).....)))))((((((......))))))(...).......((((((.((.>.((.........))...((((.((.....(((....))).......)).)))).]((((.(((..((((((...((....((....(.(...((....))....).)....))....)).))))..)))))(((((.........))))).........(..........(.(((.......))).)..).......))))...))..)))))).)..))..)))))))).))))........).[..(((((.....>].)))))..(((.(((..(((.((......((((.((((((..((.(..((((((.((.((.(((.(((..(.((.(......[..(((((..(((.......((((..........))))....)))...........].)))))).)).)..))).))).))...(((..(((((.....))))).)))....)).))))))...).))..(((......[)))((((((..........]))))))(.((...((.((((.(.(((((.........)))))...)......[[[......)))).))...((((..(((...{..)))..)))).(((....))).))]]].......(((((((.((..]]]]..))))))))).....)}......))))..)))))).......(((..(.((((((...((.......))...))))))...).)).)........(.((.((((((..((((((.(........).)))..))).(((((.....))))).....)))))..)...))..).....(((((((....))).))))....))..))).))).)))[...(((((((....(((..(.(((((.....(....)....))))).).(((((...(((....((((.((((((.}}.))))))...))))....))).)))))...(((....((((.............))))....))).)))...]....)))))))(...(.......).....(((((((((.......)))))....(((.((((.((.....(((((....)))))....))..))))..)))...))))...)..) 70S ribosome with EF-Tu-tRNA and P-site tRNA in pseudouridimycin-treated Mycoplasma pneumoniae cells; 23S ribosomal RNA 7pip 4 105 9.3 RF00001 URS000000E851_272634 36171285 0003735 0005840 272634 uuuggugcccaugucgcuguggaaacaccugguuccauuucgaacccagcaguuaagcacaguggagccgaauguagcugcagugagaauaggaaagcaccaagc <<<<<<<......<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<.......<<....>>.......>>....>>>>>>>. .(((.........((.(((((.....((((((...(.....)...))))..))....)))))..)).((.......(......).......)).......))).. 70S ribosome with EF-Tu-tRNA and P-site tRNA in pseudouridimycin-treated Mycoplasma pneumoniae cells; 5S ribosomal RNA 7pip 5 1493 9.3 RF00177,RF01959,RF01960 URS00019B76CF_272634 36171285 0003735 0005840 272634 ucugagaguuugauccuggcucaggauuaacgcuggcggcaugccuaauacaugcaagucgaucgaaaguaguaauacuuuagaggcgaacgggugaguaacacguauccaaucuaccuuauaaugggggauaacuaguugaaagacuagcuaauaccgcauaagaacuuugguucgaaucaaaguugaaaggaccugcaaggguucguuauuugaugagggugcgccauaucagcuaguuggugggguaacggccuaccaaggcaaugacguguagcuaugcugagaaguagaauagccacaaugggacugagacacggcccauacuccuacgggaggcagcaguagggaauuuuucacaaugagcgaaagcuugauggagcaaugccgcgugaacgaugaaggucuuuaagauuguaaaguucuuuuauuugggaagaaugacuuuagcagguaauggcuagaguuugacuguaccauuuugaauaagugacgacuaacuaugugccagcagucgcgguaauacauaggucgcaagcguuauccggauuuauugggcguaaagcaagcgcaggcggauugaaaagucugguguuaaaggcagcugcuuaacaguuguaugcauuggaaacuauuaaucuagagugugguagggaguuuuggaauuucauguggagcggugaaaugcguagauauaugaaggaacaccaguggcgaaggcgaaaacuuaggccauuacugacgcuuaggcuugaaaguguggggagcaaauaggauuagauacccuaguaguccacaccguaaacgauagauacuagcugucggggcgauccccucgguagugaaguuaacacauuaaguaucucgccuggguaguacauucgcaagaaugaaacucaaacggaauugacggggacccgcacaagugguggagcauguugcuuaauucgacgguacacgaaaaaccuuaccuagacuugacauccuuggcaaaguuauggaaacauaaugccgagugacagguggugcaugguugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuuaucguuaguuacauugucuagcgagacugcuaaugcaaauuggaggaaggaagggaugacgucaaaucaucaugccccuuaugucuagggcugcaaacgugcuacaauggccaauacaaacagucgccagcuuguaaaagugagcaaaucuguaaaguuggucucaguucggauugagggcugcaauucguccucaugaagucggaaucacuaguaaucgcgaaucagcuaugucgcggugaauacguucucgggucuuguacacaccgcccgucaaacuaugaaagcugguaauauuuaaaaacguguugcuaaccauuaggaagcgcaugucaaggauagcaccggugauuggaguuaagucguaacaagguaccccuacgagaacguggggguggauca .....<<<<..[.((([.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<<<<<....>>>>>>.>>>>>......<<........<<<<<<<..<<...<...<<<.<.<<.....<<<<<<....>>>>>>......>>.>.....<<<<<<<<<<..>>>>>>>>>>....<<<<<<....>>>>>>.>>>...>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>...>>>>>.>>.<<<<<............>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<.......<<<.....>>>......>>>>...<<..<<<.......<<<<<<<<<........>>>>>>>>.>.......>>>...>>.....<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<..<<<<<<<<<<.....<<<<<<<.....>>>>>>>..>>>>>>>>..>>.>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<<..<<........>>.....>>>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<......>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..].))).]<<<<<.<<<<<<<.<<.<<<<<...<<<<<<<<.<......<<........>>..........<<<<<<<.......<<<<<.....<<<<<<....>>>>>>..>>>>.>..<<<.<<<...<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<.........>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>.>>>>>>...>>>>>>>...>..>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>....>>>>>>>......<....<<<<<<<........>>>>>>>....>......>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<..<<<<<....<<<<<<.<<<..<<....>>.>>>>>>>>>...>>>>>..>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .....(((...[..[[...))).((((.(.(((...((((((((....(((..((..(((..((.((((((....)))))).)))))......(((.......(((((((..((...(..(((.((.((.....((((((....))))))......)).).....(((((((.((..)).)))))))....((((((....))))))).)))..)..))))))))).((.....((...(((((.((.......)).))))).)).......))..((((((((....))))...))))))).(((((............))))).((((....))))...)).))).).....(..((...(((((....)))).))).).)).)))))...((((.......(((.....)))......))))....(...((...(.....((.((((........)))).)).....)....))....)......((((([[[...(((((.....((.]]])).......))))))))))..))).)))))..........((([[...(.((((...(((.((((.(..((((.(((((......((.(((.....))).))...))))).))..)).).))))..((((.((((....(((((((....(((((.(...((........))......).)))))....).......((....)).))))))...))))..)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((...((.(((.((......)).))).))....((..]])).....)))))))))).(((.......(((....))).....)))....]]..](((((..((.(((.((.((((....((((((((........((........))..........(((((....(...(.((((......(((((....)))))...))))..)).((.((....((((((.(....((((((.((....))....(((......)))...)))))).....((((.(((.(((.........))).)))..(..(((((....))))).....)..)))).....).).)))...))..))))......)))))......)))))))).(...((((((......(((..(((.((((....))))).))....))).....))))))......(.....((((((........)))))).....)..)....))))....(((((((..........)))))))......))...))).)).))).))..(.(..((.(.((((.(((..((.(((...((.(....((.(((.(((..((....)).)))))).))...).))...))).))..))).))))..).))...)..)..(((((((((....)))))))))}..... 70S ribosome with EF-Tu-tRNA and P-site tRNA in pseudouridimycin-treated Mycoplasma pneumoniae cells; 16S ribosomal RNA 7pip 6 76 9.3 RF00005 URS000054164D_272634 36171285 0030533 0006412 272634 ggucuuguagcucagucgguagagcaacggucugaagaaccgugugucggcaguucgauucugcccgagaccacca <<<<<<<..<<<<........>>>><<<<<.........>>>>.>...<<<<<.......>>>>>>>>>>>>.... (((((((..((((........))))..(((.........)))......(((((.......)))))))))))).... 70S ribosome with EF-Tu-tRNA and P-site tRNA in pseudouridimycin-treated Mycoplasma pneumoniae cells; tRNA-Phe 7pip 7 76 9.3 RF00005 URS000054164D_272634 36171285 0030533 0006412 272634 ggucuuguagcucagucgguagagcaacggucugaagaaccgugugucggcaguucgauucugcccgagaccacca <<<<<<<..<<<<........>>>><<<<<.........>>>>.>...<<<<<.......>>>>>>>>>>>>.... (((((((..((((........))))..(((.........)))......(((((.......)))))))))))).... 70S ribosome with EF-Tu-tRNA and P-site tRNA in pseudouridimycin-treated Mycoplasma pneumoniae cells; tRNA-Phe 7piq 3 2878 9.7 RF02540,RF02541 URS0000AB9B3C_272634 36171285 0003735 0005840 272634 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.<.......<<<<.<<<<<<....<<<..<<<<<<<<<<.<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>....<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<....<<<<<<....>>>>>>......<<<<<<<<<...<.<<...<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>..>>>.>>>>>..>>>>.....<<<<<<<<.......>>>>>>>>.......<<<<..((((>>>>...>>>.......>.>>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>.............>....>>>>>>.>>>>.......<<<<..<<<<......>>>>..>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<...<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<.<<........>>.>>>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><.<<<<<<....<<<<<<<<<<.....<<<....<<..<<<<....<<<<....>>>.>....>>>>..>>..>>.>.....>>>>>>>>>>...>>>>>>..>..<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<.........>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<....>>>>>>>....>>>>>><<<<<<<<<<<<......<<<<<.<<....>>.>>>>>...>>>>>>>>>>.>>.....>>>>>>.......<<...<<<<<<.......>>>>>><.<<....<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<.<...<<<<<...<<<<..<<<...<<<<<<<<<....[[[...>>>>><<..<<<<<...<<<.<<<<<..<<.....>>.>>>>>.....>>>...>>>>>...>>...<<.......>>....>>>>....>.>>...>>>>........>>>>>..>......>>>>>>>>>>>>>>>..>>.....<<......>>.>>>>.<<<<.....>>>>..>>>...<<<<<...<<<<<<<<..<...............<<<<<...............>>>>><<<<<<......>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<.<<<..<<....>>...>>>>....>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>....................<.<<<<.....>>>>.>..........>>>>>..>>.>>>>>>>.....>..>>>>>>>>>>>>>>>...........<<<<<........>>>>>..<<<<<<<..<<<.<<......<<<<.<<<<<<..<<<<..<<<<<<<<..<<.<<<.<<<<...<<...........<<<<<..<<.......<<<<<<<......>>>>>>>....>>.............>>>>>..>>...>>>>.>>>.>>...<<<..<<<<<.....>>>>>.>>>.....>>>>>>>>...>>>>...<<<.....>>>.<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>..........(((......>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>........<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>......>>>.>.....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>>>....<<<<<<<....<<<...<<<<<<...............>>>>>>.<<<<<<...<<<<...<<<<<<<<<<<.]]]>>>>>>..>>>>>...>>>>.>>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>........>>>>>>>..................<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>.....>. ...(.....((((.(((((.....(((..(((((((((((((......(((((.....[[[..)).....((.(((...((.]]].....))......))).))...)))....(((....)))(.((((((....)))))).)..((((((((.........))))))))..))....((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...(((((...(.))))))......(((((((((....(.(...(((((((.((..((...(((((......)))))[[......(((.....]])))...))....)).)))))))...).))))))..))))).....((((.(((.[..).)).))))........((((].[[[[))))...)))......)).))))))).))...............((....))....))......(..((((....))))............)).....))))).)))).....(.(.((..((((..[...))))..)).).<.(.(........).)..(((((....(((((((.(((((....((...(((.....)))...))....((....))..(.(.......).)....))))).)))))))..((.(...(((.((.....((((((.(((.((((...((((((......))))))...).)))...(((.((.((........)).)))))..).)).)))))).(.((.......))...)..)).)))......).))..((((((....((((......))))((((((((....((((((((.(.....(.(....(((.((((....((((.().))).)....)))).)))..)..)......)))))))))...)))))).))..((((((((((......))))))))))....(((......)))....(((..((...((([[[...(..((((.....(.....((..(..(((.(((.....{.(((((.(.(..(((.........)))..).).....(...((......)).).)))))...))).)))..).))...........]]].)...))))..))))...).)))).(.(((((....))))).)....))))))(.(((((..(((........(.(.((....))].).)....)))..)))))..).....)))))......(.((...((((((.......))))))(..(....(((...((..(((((((...((.....)).))))))....[[((((.((...(((...((......))...)))...))...(((((........)))))]]((((((((((..(...(((((...((((..(.....((((((((......{{....))))((..(((((...((((((((...((.....))..)))))....)))...)))))...))...((.......))....)))).......)...))))(..)....)))))...)......)))))))))))))).))).....((......))..))).((((.....))))..)..)..((((....((((((((..(..(....(.......(((((....(.[..).....)))))(((((........)))))(...).......(.(((((((...((.........))...(((((((.....(((....))).......))))))).]((((.(((..(.(((((..(((...((.....(((..((....))...))).....))...))))))))...))))(.(((.........))).).........(..........(.(((.......))).)..).......))))...)).))))).).)..))..)))))))).))))))..)...).[..(((((.....>].)))))..(((((((...((.((......((((.((((((..((((...(.(((((..((.(((.((((..(((.(......[..(((((..(((.......((((..........))))....)))...........].)))))).)))..)))).))).))...(((..(((((.....))))).))).....))))).)....))))..(.(......[).)((((((..........]))))))(.((...((.((((.(.(((((.........)))))...)..(.[.[[[).....)))).))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..)))))).......((((.(.((((((...((.......))...))))))...)))).)........(.((.((((((..((.(((.(........).)))...)).(((((.....))))).....)))))..)...))..).....(((((((....))).))))....))..))..)))))))[...(((((((....(((..(.(((((.....(....)....))))).).(((((...((((...((((.((.(((.}}.))).))...))))...)))).)))))...(((....((.(.....}.......).))....))).)))...]....)))))))(...(.......).....(((((((((.......)))))....(((.((((.(((....(((((....)))))...)))..))))..)))...))))...)).. 70S ribosome with A- and P-site tRNAs in pseudouridimycin-treated Mycoplasma pneumoniae cells; 23S ribosomal RNA 7piq 4 105 9.7 RF00001 URS000000E851_272634 36171285 0003735 0005840 272634 uuuggugcccaugucgcuguggaaacaccugguuccauuucgaacccagcaguuaagcacaguggagccgaauguagcugcagugagaauaggaaagcaccaagc <<<<<<<<.....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<.....<.<<....>>...>...>>...>>>>>>>>. .((((........((((((((.....((((((...(.....)...))))..))....)))))).)).((.......(......).......))......)))).. 70S ribosome with A- and P-site tRNAs in pseudouridimycin-treated Mycoplasma pneumoniae cells; 5S ribosomal RNA 7piq 5 1493 9.7 RF00177,RF01959,RF01960 URS00019B76CF_272634 36171285 0003735 0005840 272634 ucugagaguuugauccuggcucaggauuaacgcuggcggcaugccuaauacaugcaagucgaucgaaaguaguaauacuuuagaggcgaacgggugaguaacacguauccaaucuaccuuauaaugggggauaacuaguugaaagacuagcuaauaccgcauaagaacuuugguucgaaucaaaguugaaaggaccugcaaggguucguuauuugaugagggugcgccauaucagcuaguuggugggguaacggccuaccaaggcaaugacguguagcuaugcugagaaguagaauagccacaaugggacugagacacggcccauacuccuacgggaggcagcaguagggaauuuuucacaaugagcgaaagcuugauggagcaaugccgcgugaacgaugaaggucuuuaagauuguaaaguucuuuuauuugggaagaaugacuuuagcagguaauggcuagaguuugacuguaccauuuugaauaagugacgacuaacuaugugccagcagucgcgguaauacauaggucgcaagcguuauccggauuuauugggcguaaagcaagcgcaggcggauugaaaagucugguguuaaaggcagcugcuuaacaguuguaugcauuggaaacuauuaaucuagagugugguagggaguuuuggaauuucauguggagcggugaaaugcguagauauaugaaggaacaccaguggcgaaggcgaaaacuuaggccauuacugacgcuuaggcuugaaaguguggggagcaaauaggauuagauacccuaguaguccacaccguaaacgauagauacuagcugucggggcgauccccucgguagugaaguuaacacauuaaguaucucgccuggguaguacauucgcaagaaugaaacucaaacggaauugacggggacccgcacaagugguggagcauguugcuuaauucgacgguacacgaaaaaccuuaccuagacuugacauccuuggcaaaguuauggaaacauaaugccgagugacagguggugcaugguugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuuaucguuaguuacauugucuagcgagacugcuaaugcaaauuggaggaaggaagggaugacgucaaaucaucaugccccuuaugucuagggcugcaaacgugcuacaauggccaauacaaacagucgccagcuuguaaaagugagcaaaucuguaaaguuggucucaguucggauugagggcugcaauucguccucaugaagucggaaucacuaguaaucgcgaaucagcuaugucgcggugaauacguucucgggucuuguacacaccgcccgucaaacuaugaaagcugguaauauuuaaaaacguguugcuaaccauuaggaagcgcaugucaaggauagcaccggugauuggaguuaagucguaacaagguaccccuacgagaacguggggguggauca .....<<<<..[.((([.>>>>..<<..<<<<<..<<<<<<<<..<..<<..<<<..<<<..<<.<<<<<<....>>>>>>.>>>>>......<<........<<<<<<<..<<......<<<<<<.<<.....<<<<<......>>>>>......>>.>.....<<<<<<<<.<.>..>>>>>>>>....<<<<<<....>>>>>>>>>>>.....>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<..[.>>>...>>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>.>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<...>>>>>.....>>>>...<...<<<.......<<<.<<<<<........>>>>>.>>>........>>>....>.....<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>.>>........]..<<<((.....<<<<...<<<.<<<<<<..<<<<<<<<<<.....<<<<<<<.....>>>>>>>..>>>>>>>>..>>.>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<......>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<.....<<<<<....>>>>>...>>>..].))).]<<<<<.<<<<<<<..<..<<<<...<<<<<<<<..<.....<<........>>..........<<<<<<.........<<.<.....<<<<<......>>>>>..>.>>....<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<..<<<<<.............>>>>>.....<<<<<....>>>>>.........>>>.........>>>...>>>>>>>>>....>>>>>>...>..>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>....>>>>>>>......<....<<<<<<<........>>>>>>>....>......>>>>.....<<<<<<<..........>>>>>>>......>....>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<.<<<<..<<<<<....<<<<<.<<<<..<<....>>.>>>>>>>>>...>>>>>..>>>>.>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .....((((..[.[[[..)))).((((.(((((...((((((((....((..((...(((..((.((((((....)))))).)))))......(((.......((.((((..((...(..((((((.((.....(((((......)))))......)).)......((((((........)))))).....((((((....)))))))))))..)..)))))).)).(((....((...(((((.((.......)).))))).))......)))..((((((((....))))...))))))).(((((............))))).((((....))).)...)).)).).....(..((...(.(((....)))..))).).)).)))))...((((......((((.....)))).....))))....(..(((...(...(...(((((........)))).)...)..)....)))...)......(.((([[[...(((((.....((.]]])).......)))))))).)..)))))))))..........((([[...(.((((...(((.((.(..(.(((((..((.......((.(((.....))).))....))..)))..)).).).))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))..........((((((..(((((((.((......)).)))))))...((..]])).....)))))))))).(((.......(((....))).....)))....]]].](((((..(..(((..(..((((...((((..((........((........))..........(((......(....(.(.((....(((..(....)..))).)).)..).).((.((....((.(((.(....((((((.((....))....(((......)))...)))))).....((.(.(((...(.........)...)))..(..(.(((....))).).....)..).)).....).).))....))..))))........)))......))..)))).(...((((((......(((..((...(((....)))...))....))).....))))))......(....(((((.(........).)))))....)..)...)))).....(((((((..........)))))))......)....)))..).))).))..(.(..((.(.((((.(.(..((.(((..(((((....((.(((.(((..((....))).))))).))...)))))..))).))..).).))))..).))...)..)..(((((((((....)))))))))...... 70S ribosome with A- and P-site tRNAs in pseudouridimycin-treated Mycoplasma pneumoniae cells; 16S ribosomal RNA 7piq 6 76 9.7 RF00005 URS000054164D_272634 36171285 0030533 0006412 272634 ggucuuguagcucagucgguagagcaacggucugaagaaccgugugucggcaguucgauucugcccgagaccacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (.((..(..((((........))))..((((.......))))......(((((.......))))))..)).).... 70S ribosome with A- and P-site tRNAs in pseudouridimycin-treated Mycoplasma pneumoniae cells; tRNA-Phe 7piq 7 76 9.7 RF00005 URS000054164D_272634 36171285 0030533 0006412 272634 ggucuuguagcucagucgguagagcaacggucugaagaaccgugugucggcaguucgauucugcccgagaccacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (.((..(..((((........))))..((((.......))))......(((((.......))))))..)).).... 70S ribosome with A- and P-site tRNAs in pseudouridimycin-treated Mycoplasma pneumoniae cells; tRNA-Phe 7pir 3 2878 12.1 RF02540,RF02541 URS0000AB9B3C_272634 36171285 0003735 0005840 272634 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.........<<<<.<<<<<<.....<<..<<<<<<<<<<<<<......<<<<<<.....((.>>>.....<<<<<<<..<<<)).....>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>....<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<....<<............>>......<<<.<<<<<.....<<...<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>..>>..>>>>>...>>>.....<<<<<<<<.......>>>>>>>>......<<<<<..<<<<>>>>>..>>>......>>.>>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>.>>>>.......<<<<..<<<<......>>>>..>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<.....<<...<<<.....>>>...>>....<<....>>..<<<.......>>>.....>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<.<<........>>.>>>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<..<<....<<<<<....>>>>>..<<<<<<......<<<<<<<<.....<<<.....<..<<<<<...<...........>...>>>>>..>...>>.>.....>>>>>>>>.....>>>>>>.....<<<<<<.<<<......>>>.>>>>>>....<<<......>>>...<<<<.<<<...<<<(((...<<<<<<<...........<<..<<<<<<<.<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>.>>>>>>>.>>...........))).....>>>>>>>>>>...>>>>>>>.<<<<<<....>>>>>>.....>>..>>..<<<<<<<<<<.......<<<<.<<....>>.>>>>....>>>>>>>>>>........>>>>>>.......<<...<<<<<<.......>>>>>>..<<....<<<...<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>....<<<<........>>>>.)).<<<<<<..<<.<...<<<<....<<<....<....<<<.<<<<<....(((...>>>>><<..<<<<<.....<.<<<<<..<<.....>>.>>>>>.....>.....>>>>>...>>...<<.......>>.....>>>......>.....>>>.........>>>>..>......>>..>>>>>>.>>>>..>>.....<<......>>..>>>.<<<.......>>>..>>....<<<<<...<<<<<<<<..<...............<<<<<...............>>>>><<<<<<......>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>..<<<<.<<<..<<<<<<<..<<<....<....<<<<..<<....>>...>>>>....>....>>>>>>>>..>>>>><<<<<<.......>>>>>>......................<<<<.....>>>>............>>>>...>>.>>>>>>>.....>..>>>>>>>>>>>>>>>...........<<<<<........>>>>>..<<<<<<<..<<<.<<......<<<<.<<<<<<..<<<<..<<<<<<<<..<<.<<<.<<<...<<<...........<<<<<..<<<......<<<<<<<......>>>>>>>...>>>.............>>>>>..>>>...>>>.>>>.>>...<<<..<<<<<.....>>>>>.>>>.....>>>>>>>>...>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.........[.((......>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))].......<<<<<<.<<<..>>>>..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.........<<<..<<<<<..<<<<<<<<........>>>>>>..>>.<<<<<.....>>>>>.....>>>>>......>>>.......<<<<<<<....>>>.>>>>....>>..>>>.>>>>>>>....<<<<<<<....<<<..<<<<<<<...............>>>>>>><<.<<<...<<<<...<<<<<<<<<<..))).>>>>>..>>>>>...>>>>.>>>>>....<<.<..<<<<<...........>>>>>...>>>..>>>........>>>>>>>..................<<<<<<<<<.......>>>>>....<<<<<<<<...<....<<<<<....>>>>>...>....>>>>>.>>>...>>>>....... .........((((.(((((.....(((..(((((((((((((......(((((.......[..)).....((.(((...(((]......)))......))).))...)))....(((....)))(.((((((....)))))).).((((((((...........)))))))).))....(((((......(......).......)))).)...(.....((....))...(((((.....(.......)....)))).)..((((...(((.(......).)))......((((((.((.....((...((((.((.((.(((...(((((......)))))[[......(((.....]])))...)))...)).).)))))..))..)).))..))))).....(((..(((.[..).))..))).......(((((]..[[[)))))..)))....).)).))))))).))...............((....))....))......(..((((....))))............)).....))))).)))).....(.((((..((((..[...))))..)))).<.(((........))).(((.((....(((((((((((.(....(....(((.....)))....)....((....))..(.(.......).)....).)))))))))))..((.(...((((((.....(((((.((((.((((....(((((......)))))....).)))...(((.((.((........)).)))))..).))).))))).(.((.......))...)..))))))......).))..((..(.....(((((....))))).(((((......(.((((((((.....(.(....(((.((((....(...........)....)))).)))..)..).....)))))))).).....)))).)...(((((((.((......)).)))))))....((.(.....)))....((..(((...((([[[...(((..((.....(.....((..((((((((((.....{.(((((.(.(...((.........).)..).).....(...((......)).).)))))...)))))))))).))...........]]].)...))..))))))...))).))....((((....))).).......)..))(.((((((.(((........(((.((....))]))).....))).))))))..).....)).)))............((((((.......))))))(..(....((....((..(((((((...((.....))[))))))....[[((((.((...((....(((....)))....))...))....((((........)))).]](.((((((.(((....((((....((.(..(.........(((((.....{{...)))))(...((((...((((..((((..((.....)).))))......))))...))))....)...((.......))...............)...).))(..).....))))...).....)).)))))).))))).)))...].((......))...)).(((.......)))..)..)..((((....((((((((..(..(............(((((....(....).....)))))(((((........)))))(...).......((((((((....((.........))...(((((((.....(((....))).......)))))))..((((.(((..((.((((..(((....(....(.((..((....))...))..)...)....)))))))...)))))(((((.........))))).........(..........(.(((.......))).)..).......))))....).)))))))....))..)))))))).))))........).[..(((((.....>].)))))..((((((...(((.((......((((.((((((..((((...(.(((.(..((.(..((((..((((.(......[..(((((..(((.......(((((........)))))....)))...........].)))))).))))..))).).).))...(((..(((((.....))))).))).....).))).)....))))..(((......[)))((((((..........]))))))([((....(.((((.(.(((((.........)))))...)...][.[[[......)))).)....((((..(((...{..)))..)))).(((....))).))]]].].....((.(((..((..]]]...)).))).)).....)}......))))..)))))).......(((..(..(((((...((.......))...)))))....).)).)........(.((.((((((..((.(((((........)))))...)).(((((.....))))).....)))))..)...))..).....(((((((....))).))))....))..)))..))))))[...(((((((....(((..(((((((.....(....)....))))))).(.(((...(((....(((((((.(((.}}.))).))..)))))....))).))).)...(((....((.(.....}.......).))....))).)))...]....)))))))(.................(((((((((.......)))))....((((((((..((.....((((....))))....))...))))).)))...))))...)... 70S ribosome with A*- and P/E-site tRNAs in pseudouridimycin-treated Mycoplasma pneumoniae cells; 23S ribosomal RNA 7pir 4 105 12.1 RF00001 URS000000E851_272634 36171285 0003735 0005840 272634 uuuggugcccaugucgcuguggaaacaccugguuccauuucgaacccagcaguuaagcacaguggagccgaauguagcugcagugagaauaggaaagcaccaagc .<.<<<<......<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<......................>>....>>>>.>.. .(..(((......(((((((.(....((((((...(.....)...))))..))....)))))).))..........(......).............)).).).. 70S ribosome with A*- and P/E-site tRNAs in pseudouridimycin-treated Mycoplasma pneumoniae cells; 5S ribosomal RNA 7pir 5 1493 12.1 RF00177,RF01959,RF01960 URS00019B76CF_272634 36171285 0003735 0005840 272634 ucugagaguuugauccuggcucaggauuaacgcuggcggcaugccuaauacaugcaagucgaucgaaaguaguaauacuuuagaggcgaacgggugaguaacacguauccaaucuaccuuauaaugggggauaacuaguugaaagacuagcuaauaccgcauaagaacuuugguucgaaucaaaguugaaaggaccugcaaggguucguuauuugaugagggugcgccauaucagcuaguuggugggguaacggccuaccaaggcaaugacguguagcuaugcugagaaguagaauagccacaaugggacugagacacggcccauacuccuacgggaggcagcaguagggaauuuuucacaaugagcgaaagcuugauggagcaaugccgcgugaacgaugaaggucuuuaagauuguaaaguucuuuuauuugggaagaaugacuuuagcagguaauggcuagaguuugacuguaccauuuugaauaagugacgacuaacuaugugccagcagucgcgguaauacauaggucgcaagcguuauccggauuuauugggcguaaagcaagcgcaggcggauugaaaagucugguguuaaaggcagcugcuuaacaguuguaugcauuggaaacuauuaaucuagagugugguagggaguuuuggaauuucauguggagcggugaaaugcguagauauaugaaggaacaccaguggcgaaggcgaaaacuuaggccauuacugacgcuuaggcuugaaaguguggggagcaaauaggauuagauacccuaguaguccacaccguaaacgauagauacuagcugucggggcgauccccucgguagugaaguuaacacauuaaguaucucgccuggguaguacauucgcaagaaugaaacucaaacggaauugacggggacccgcacaagugguggagcauguugcuuaauucgacgguacacgaaaaaccuuaccuagacuugacauccuuggcaaaguuauggaaacauaaugccgagugacagguggugcaugguugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuuaucguuaguuacauugucuagcgagacugcuaaugcaaauuggaggaaggaagggaugacgucaaaucaucaugccccuuaugucuagggcugcaaacgugcuacaauggccaauacaaacagucgccagcuuguaaaagugagcaaaucuguaaaguuggucucaguucggauugagggcugcaauucguccucaugaagucggaaucacuaguaaucgcgaaucagcuaugucgcggugaauacguucucgggucuuguacacaccgcccgucaaacuaugaaagcugguaauauuuaaaaacguguugcuaaccauuaggaagcgcaugucaaggauagcaccggugauuggaguuaagucguaacaagguaccccuacgagaacguggggguggauca .....<<<<..[.(((..>>>>..<<<.<<<<<...<<<<<<................<<..<<.<<<<<<....>>>>>>.>>>>.......<<........<.<.<<<..<<........<<.<.<<.....<<<<<<....>>>>>>......>>.>.....<<<<.............>.>>>....<<<<<<....>>>>>>.>>.......>>>>>.>.>.<<.....<<<..<<<<<<<<.......>>>>>>>>>>>.......>>..<<<<<<<<....>>>...>>>>>.>>.<<<<<............>>>>>.<<<<....>>>>..................<<<....<<<<....>>>>..>>>...>.>>>>>...<<<<.......<<<.....>>>......>>>>...<..<.<<........<<<<<<<..........>>>>>>>.........>>>....>.....<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>...........<<<(......<<<<...<<<.<<<<<<..<<<<<.<<<<.....<<<<<<<.....>>>>>>>..>>>>.>>>..>>.>>>>>>...<<<.<<<<...<<<<<<<....<<<<<<<<<..<<........>>.....>>>>>>>>>...........<<....>>.>>>>>>>..>>>>..>>>...>>>...>>>>....<<<<<<<.......<<<<.........>>>>....>>>>>>>..........<<<<<<..<<<<<<<<<<......>>>>>>>>>>...<<...)>>.....>>>>>>.>>>.<<<.......<<<....>>>.....>>>....))).]<<.<<.<<<<<<<.....<<<....<<<<<<<<<<......<<........>>..........<<<<<<.........<<<<<....<<<.<<....>>.>>>.>>>>>....<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<.........>>>>>>>.....<<<<<....>>>>>........>>>>.........>>...>>>>>>>>>>....>>>>>>...>>.>>>>>>>>.....<<<<<<......<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>......<....<<<<<<<........>>>>>>>....>.......>>>.....<<<<<<<..........>>>>>>>...........>>>>>>>>>..>>....<..<<.<.<<<<.<....<<<<<<..<<<<.....<<<<<<.<<<..<<....>>.>>>>>>>>>...>.>>>..>>>>>>....>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .....(((...[.[[[...)))..((..((((.(..((((((((.............(.(..((.((((((....)))))).))).)......(((........(..(((.......(....(.((.((.....(((((......)))))......)).)......((..((........))..)).....(.(((......))).)).)....)....)))..)..((.....((...(((((.((.......)).))))).)).......))..(((((..(.....).)...))))))).(((((............))))).((((....))))..........).....(..((...(.(((....)))..))).).)).)))))...((((......((((.....)))).....))))..(.(..(((...(......((((((........))))))......)....)))...)....).((((([[[...(((((.....((.]]])).......))))))))))..))))).))...........((([[...(.((((....((.((((.(..(((((.((((......(..(((.....)))..)...)))).)).).)).).))))..(((..((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))))...))..)))....))))....((((((....(...((((.........))))...).))))))......{...(((.((....(.((((((......)))))).).....((..]])).....)).))))))).(.(.......(((....))).....).)....]]].]((..(.(((.(((.....(..(...((((.((((.(.....((........))..........(((((....(.......(.(......(..(....)...)..).).....).((.((....((.(((.(....((((((.((....))....(((......)))...)))))).....((((.(((((((.........)))))))..(..(.((......)).).....)..)))).....).).))....))..))))......)))))...)).))).)))).(...((((((......(((..((...(((....)))...))....))).....))))))......(....(((((.(........).)))))....)..)...)..).....(.(((((..........))))).)...........))).))))...))..(.(..((.(.((((.((....(((((..(...(....((.(((.(((..((....)).)))))).))...)...)..)))))....)).))))..).))...)..)..(((((((((....)))))))))}..... 70S ribosome with A*- and P/E-site tRNAs in pseudouridimycin-treated Mycoplasma pneumoniae cells; 16S ribosomal RNA 7pir 6 76 12.1 RF00005 URS000054164D_272634 36171285 0030533 0006412 272634 ggucuuguagcucagucgguagagcaacggucugaagaaccgugugucggcaguucgauucugcccgagaccacca <<<..<<..<<<<........>>>>..<<<<.......>>>>......<<<<<.......>>>>>>>..>>>.... ..(...(..((((........))))...(((.......))).......(((((.......))))))...)...... 70S ribosome with A*- and P/E-site tRNAs in pseudouridimycin-treated Mycoplasma pneumoniae cells; tRNA-Phe 7pir 8 76 12.1 RF00005 URS000054164D_272634 36171285 0030533 0006412 272634 ggucuuguagcucagucgguagagcaacggucugaagaaccgugugucggcaguucgauucugcccgagaccacca <<<..<<..<<<<........>>>>..<<<<.......>>>>......<<<<<.......>>>>>>>..>>>.... ..(...(..((((........))))...(((.......))).......(((((.......))))))...)...... 70S ribosome with A*- and P/E-site tRNAs in pseudouridimycin-treated Mycoplasma pneumoniae cells; tRNA-Phe 7pis 3 2878 15.0 RF02540,RF02541 URS0000AB9B3C_272634 36171285 0003735 0005840 272634 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.<<......<<<<.<<<<<<....{[[.(((<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>....<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((....<<............>>......<<<<<<<<<.....<<...<<<<<<<<<<.<<<....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>..>>..>>>>>..>>>>.....<<<<<<<<.......>>>>>>>>.......<<<<..<<<<>>>>...)))......]].>>>>>>>.)))..............<<....>>....]].........<<<<....>>>>.............}....>>>>>>.>>>>.......<<<<..<<<<......>>>>..>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<.........<<<.....>>>.........<<....>>..<<<<.....>>>>....>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<.<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<.<<........>>.>>>>>....>>.>>>>>>>..<<.......>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<....<<..<.<<<<.....<<<....<<...<<<......<<....>>.......>>>...>>..>>.>.....>>>>>..>.>...>>>>>>.>>..<<<<<<.<<<......>>>.>>>>>>....<<<......>>>...<<<<.<<<...<<<<<<.......(((...........<<..<<<<<<<..........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>......>>>>>>>.>>...........>>>.....)))....>>>...>>>>>>><<<<<<......>>>>>>....>>>>>>..<<<<<<<<<<......<<<<<.<<....>>.>>>>>...>>>>>>>>>>........>>>>>>............<<<<<<.......>>>>>>..<.....<<.<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<..<<...<<<...<<<....>>>...>>>...>>....<<<<........>>>>.))<<<<<<..<<<<<...<<<<<...<<<<...<<.....<<<<<<<....(((...>>>>>....<<<<<..<<<<<<<<<<..<<.....>>.>>>>>>....>>>>..>>>>>.......................>>......>.>....>>>>........>>>>.>.>>.....>>>..>>>>>>.>>>..>>.....<<......>>>>.>>.<<<<.....>>>>...>....<<<<<...<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<......>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>..<<<<.<<<..<<<<<<<..<<<...<<....<<<<..<<....>>..>.>>>....>>...>>>>>>>>..>>>>><<<<<.........>>>>>......................<<<<.....>>>>............>>>>...>>.>>>>>>>.....>>.>>>>>>>>>>>>>.............<<<<<........>>>>>..<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<...<<<<<<...<<.<<<.<<<...<<<...........<<<<<..<<<......<<<<<<<......>>>>>>>...>>>.............>>>>>..>>>...>>>.>>>.>>...<<<..<<<<<.....>>>>>.>>>......>>>>>>....>>>>..<<<.......>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>..........(((......>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<.(((..>>>>..)))>>>>>>.............>>>>..]]>>>>.......<<<<..<<<<<<<...<<.......>>...>>>>>>>...>>>.>.........<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>......>>>.......<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<<....<<<..<<<<<<<.....<....>....>>>>>>><<<<<<...<<<<...<<<<<<<<<<<.)))>>>>>>..>>>>>...>>>>.>>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>........>>>>>>>..................<<<<<<<<<.......>>>>>....<<<<<<<<.<<<.....<<<<....>>>>....>>>..>>>>>.>>>...>>>>....>>. .((......((((.(((((.....(((..(((((((((((((......(((((......[[..)).....((((((...(((]].....)))......))))))...))).....((....).)(((((.((....)).))))).(((((((((.........))))))))).))....((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...((.(........).))......(((((((((......(...(((((((.((.(((...((((........))))[[......(((.....]])))...)))...)).)))))))...)..)))))..))))).....((((((((.[..).))))))).........(((].[[[[)))....)))......)).))))))).))...............((....))....)).........((((....)))).............).....))))).)))).....(.(.((...(((..{...)))...)).).[.(..[.........).((((((....(((((((((((.(....(....(((.....)))....)....((....))..(.(.......).)....).)))))))))))..((.(...((((((.....(.(((..(((.((((....(((((......)))))....).)))...(((.((.((........)).)))))..).))..))).).(.((.......))...)..))))))......).))..(((.((....(((((....)))))((((((((.....((..(.(((.....(.(....(.(....((...(.(((..)))..)...))....).)...).).....)))..).))....)))))).))..((((.(((.(......).))).))))....(((......)))....(((.(((...((([[[...(...(((.....(.....((..(.(((((...(......(((((.(.(...((.........).)..).).....(...((......)).).)))))...)..))))).).))...........]]].)...)))...))))...)))))).(.((((......)))).)....)).)))(.(((((..(((.......((((.((....))}))))....)))..)))))..).....))))))............((((((.......))))))(..(.....(....((...((((((...((.....)).))))))....[[(.((.((.(.((....(((....)))....))..)))...(((((........)))))]]..(((..(.(.((...(.(.....((((..((.....(.((((((....{.....)))))(...(((((...((((.((((..((.....)).)))).)....)))...)))))....)..................).).......))...))))(..)......).)..))......).)..)))..)).)..)).....((......))...)...(((.....)))...)..)..(((((...((((((((.((..(....(.......(((((....(.[..).....)))))((((((......))))))(...).......((((((.((...((.........))...(((((((.....(((....))).......))))))).]((((.(((..(((((((..(((....(....(.((..((....))...)).)....)....))))))))..)))))(.(((.........))).).........(..........(.(((.......))).)..).......))))...))..)))))).)..))).)))))))))))))........).{..(((((..]..]}.)))))..(((((((...((.((......((((.((((((..(((((..(((((.(..((..((.(((....(..(......[..(((.(..(((......((((((.(....).))))))...)))...........].).))))..)....))).))..))....((..(((((.....))))).))......).)))))...)))))..(((......[)))((((((..........]))))))(.((....(.((((.(..((((.........))))....)......[[[......)))).)....((((..(((...{..)))..)))).(((....))).))]]].......((.(((..((..]]]]..)).))).)).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((..(((((..((((((.((......)).)))..)))..((((.....))))......)))))......))..).....(((((((....))).))))....))..))..)))))))[...(((((((....(((..(((((((.....(....)....))))))).(((.(....((....(((((((.(((...}))).))..)))))....))..).)))...(((....((.................))....))).)))...]....)))))))(.................(((((((((.......)))))....((((((.(..((.....((((....))))....))...).))).)))...))))...))). 70S ribosome with EF-G, A*- and P/E-site tRNAs in pseudouridimycin-treated Mycoplasma pneumoniae cells; 23S ribosomal RNA 7pis 4 105 15.0 RF00001 URS000000E851_272634 36171285 0003735 0005840 272634 uuuggugcccaugucgcuguggaaacaccugguuccauuucgaacccagcaguuaagcacaguggagccgaauguagcugcagugagaauaggaaagcaccaagc .<<<<<<<.....<<<<<<<<.....<.<<<...............>>>...>....>>>>>>.>>.<<......................>>...>>>>>>>.. ((((..((.....((.(((((.....((((((...(.....)...))))..))....)))))..)).((......................))...))..)))). 70S ribosome with EF-G, A*- and P/E-site tRNAs in pseudouridimycin-treated Mycoplasma pneumoniae cells; 5S ribosomal RNA 7pis 5 1493 15.0 RF00177,RF01959,RF01960 URS00019B76CF_272634 36171285 0003735 0005840 272634 ucugagaguuugauccuggcucaggauuaacgcuggcggcaugccuaauacaugcaagucgaucgaaaguaguaauacuuuagaggcgaacgggugaguaacacguauccaaucuaccuuauaaugggggauaacuaguugaaagacuagcuaauaccgcauaagaacuuugguucgaaucaaaguugaaaggaccugcaaggguucguuauuugaugagggugcgccauaucagcuaguuggugggguaacggccuaccaaggcaaugacguguagcuaugcugagaaguagaauagccacaaugggacugagacacggcccauacuccuacgggaggcagcaguagggaauuuuucacaaugagcgaaagcuugauggagcaaugccgcgugaacgaugaaggucuuuaagauuguaaaguucuuuuauuugggaagaaugacuuuagcagguaauggcuagaguuugacuguaccauuuugaauaagugacgacuaacuaugugccagcagucgcgguaauacauaggucgcaagcguuauccggauuuauugggcguaaagcaagcgcaggcggauugaaaagucugguguuaaaggcagcugcuuaacaguuguaugcauuggaaacuauuaaucuagagugugguagggaguuuuggaauuucauguggagcggugaaaugcguagauauaugaaggaacaccaguggcgaaggcgaaaacuuaggccauuacugacgcuuaggcuugaaaguguggggagcaaauaggauuagauacccuaguaguccacaccguaaacgauagauacuagcugucggggcgauccccucgguagugaaguuaacacauuaaguaucucgccuggguaguacauucgcaagaaugaaacucaaacggaauugacggggacccgcacaagugguggagcauguugcuuaauucgacgguacacgaaaaaccuuaccuagacuugacauccuuggcaaaguuauggaaacauaaugccgagugacagguggugcaugguugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuuaucguuaguuacauugucuagcgagacugcuaaugcaaauuggaggaaggaagggaugacgucaaaucaucaugccccuuaugucuagggcugcaaacgugcuacaauggccaauacaaacagucgccagcuuguaaaagugagcaaaucuguaaaguuggucucaguucggauugagggcugcaauucguccucaugaagucggaaucacuaguaaucgcgaaucagcuaugucgcggugaauacguucucgggucuuguacacaccgcccgucaaacuaugaaagcugguaauauuuaaaaacguguugcuaaccauuaggaagcgcaugucaaggauagcaccggugauuggaguuaagucguaacaagguaccccuacgagaacguggggguggauca .....<<<<....(((.>.>>>.<<...<<<<<...<<<<.<......<<<.<<<..<<<..<<.<<<<<<....>>>>>>.>>>>>......<<........<<<.<<<..<<...<.......<.<<.....<<<<<......>>>>>......>>.>.....<<<<<<<........>>>>>>>....<<<<<<....>>>>>>.......>..>>>>>.>>>.<<.....<<<....<<<<<<.......>>>>>>..>>>.......>>..<<<<<<<<....>>>...>>>>>.>>.<<<<<.<.........>>>>>>.<.<<....>>.>...>>>>>>.........<<<....<<<<....>>>>..>>>...>..>>>>...<<<<........<<.....>>.......>>>>.......<<<.......<<<<<<<<<........>>>>>>>>>........>>>..........<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>.>.>..........<<<((.....<<<<...<<<.<<<<<<..<<<<<.<<<<.....<<<<<<<.....>>>>>>>..>>>>.>>>..>>.>>>>>>....<<<<<<....<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>...>>>>.>>....>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<......>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<........<<<....>>>......>>....)))..<<<<..<<<<<<<.....<......<<<<<<<<<.......<<........>>..........<<<<<<<......<...<.......<<<<<....>>>>>....>...>....<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<..<<<<<<<.........>>>>>>>.....<<<<<....>>>>>.........>>>.........>>>...>>>>>>>.....>>>>>>>....>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>....>>>>>>>...........<<<<<<<........>>>>>>>..............>.....<<<<<<<..........>>>>>>>...........>>>>>>>.>>.>>....<..<<.<.<<<<...<..<<<<<<..<..<<....<<<<<.<<<<..<<....>>.>>>>>>>>>...>>..>..>>>>>>..>...>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .....((((..[.[[[.).))).((...(.((.(...((.((.(......(.(....(((..((.((.(((....))).)).)))))......(((.......((..(((...(...(.....(((.((.....((((.(....).))))......)).).....((..(((........)))..))....((.(((....))).)))).....)..).)))..)).(......(((..(.(((.((.......)).)))).)))........)..(((((.((....)).)...))))))).(((((............)))))..(.((...)))......))...).....(..((...(.(((....)).).))).)..).).))....((((......(..(.....)..).....))))....(..(((...(....(((.((((........)))).)))....)....)))...)......(.((([[[...(((((.....((.]]])).......)))))))).)..))).)..))..........((([[...(.((((...(.(.((((((..((((...((......(((((((.....)))))))...))...))..)).))))))..((((..((....((((((((....(((((((...((........))......)))))))....).......((....)).)))))))...))...)))..))..)..)))).....(((((...((...((((.........))))...)))))))...........((((((...(((.((.((......)).)).)))....((..]])).....)))))))))).(.(.......(((....))).....).)....]]].](((((.(((((((..(..(..((..((((.(((((......((........))..........(((((((..(......((.(......(..(....)...)..).))....).((.((....((..((.(....((((((.((....))....(((......)))...)))))).....((((.(((((((.........))))))).....(.((......)).)........)))).....).).).....))..))))....)))))))...)).))).)))).(...(.((((......(((..(((.((((....))))).))....))).....)))).)......(....(((((((........)))))))....)..)..))..).....(((((((..........)))))))......)....)))))))))).))..(.(..((.(.(.((...(...(((((..(..((....((((((.(((..((....)).)))))))))...))..)..)))))...)...)).)..).))...)..)..(((((((((....)))))))))...... 70S ribosome with EF-G, A*- and P/E-site tRNAs in pseudouridimycin-treated Mycoplasma pneumoniae cells; 16S ribosomal RNA 7pis 6 76 15.0 RF00005 URS000054164D_272634 36171285 0030533 0006412 272634 ggucuuguagcucagucgguagagcaacggucugaagaaccgugugucggcaguucgauucugcccgagaccacca <<<<<<...<<<<........>>>>..<<<<......>.>>>......<<<<<.......>>>>>.>>>>>>.... ((.(..(..((((.....[..))))...((.........)).......(((((..]....))))))..).)).... 70S ribosome with EF-G, A*- and P/E-site tRNAs in pseudouridimycin-treated Mycoplasma pneumoniae cells; tRNA-Phe 7pis 8 76 15.0 RF00005 URS000054164D_272634 36171285 0030533 0006412 272634 ggucuuguagcucagucgguagagcaacggucugaagaaccgugugucggcaguucgauucugcccgagaccacca <<<<<<...<<<<........>>>>..<<<<......>.>>>......<<<<<.......>>>>>.>>>>>>.... ((.(..(..((((.....[..))))...((.........)).......(((((..]....))))))..).)).... 70S ribosome with EF-G, A*- and P/E-site tRNAs in pseudouridimycin-treated Mycoplasma pneumoniae cells; tRNA-Phe 7pit 3 2878 5.7 RF02540,RF02541 URS0000AB9B3C_272634 36171285 0003735 0005840 272634 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.........<<<<.<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>....<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...(((....<<<<<......>>>>>......<<<<<<<<<.....<<...<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>..>>..>>>>>..>>>>.....<<<<<<<<.......>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<....>>>>.............}....>>>>>>.>>>>.......<<<<..<<<<......>>>>..>>>>...<<..........>>.<<<<<<....<<<<<<<<<<<<<...<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<.<<........>>.>>>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<....<<<<<<<<<<......<<....<<..<<<<....<...........>....>>>>..>>..>>.......>>>>>>>>>>...>>>>>>.>>..<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((....<<<<<<...........<<..<<<<<<<..........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>......>>>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<....>>>>>>>....>>>>>><<<<<<<<<<<<......<<<<<.<<....>>.>>>>>...>>>>>>>>>>.>>.....>>>>>>.......<<...<<<<<<.......>>>>>>.<<<....<<....<<<..<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>....<<<<........>>>>.))<<<<<<<<<<<.<....<<<<...<<<<..<<<<..<<<<<<<<<....(((...>>>>><<..<<<<<..<<<<<<<<<<<.<<.....>>>>>>>>>....>>>>..>>>>>...>><..<<.......>>...>>>>>....>>>>...>>>>........>>>>...>......>>>>>>>>>>>>>>>.>>>.....<<......>>...>>.<<<<.....>>>>..>>>...<<<<<...<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<......>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>..<<<<.<<<..<<<<<<<..<<<...<<..<.<<<<..<<....>>..>.>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<.<<<<.....>>>>.>.....>....>>>>...>>.>>>>>>>.....>>.>>>>>>>>>>>>>>>...........<<<<<........>>>>>..<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<<.<<.<<<.<<<<.<<<<...........<<<<<..<<.......<<<<<<<......>>>>>>>....>>.............>>>>>..>>>>.>>>>.>>>.>>...<<<..<<<<<.....>>>>>.>>>....>>>>>>>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>......<...(((>.....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.........<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.......<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<<....<<<..<<<<<<<...............>>>>>>><<<<<<...<<<<...<<<<<<<<<<<.)))>>>>>>..>>>>>...>>>>.>>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>........>>>>>>>..................<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....... 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70S ribosome with EF-G, A/P- and P/E-site tRNAs in pseudouridimycin-treated Mycoplasma pneumoniae cells; 23S ribosomal RNA 7pit 4 105 5.7 RF00001 URS000000E851_272634 36171285 0003735 0005840 272634 uuuggugcccaugucgcuguggaaacaccugguuccauuucgaacccagcaguuaagcacaguggagccgaauguagcugcagugagaauaggaaagcaccaagc <<<<<<<<.....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<.......<<<..>>>.......>>...>>>>>>>>. .(((.........((((((((.....((((((...(.....)...))))..))....)))))).)).((......................)).......))).. 70S ribosome with EF-G, A/P- and P/E-site tRNAs in pseudouridimycin-treated Mycoplasma pneumoniae cells; 5S ribosomal RNA 7pit 5 1493 5.7 RF00177,RF01959,RF01960 URS00019B76CF_272634 36171285 0003735 0005840 272634 ucugagaguuugauccuggcucaggauuaacgcuggcggcaugccuaauacaugcaagucgaucgaaaguaguaauacuuuagaggcgaacgggugaguaacacguauccaaucuaccuuauaaugggggauaacuaguugaaagacuagcuaauaccgcauaagaacuuugguucgaaucaaaguugaaaggaccugcaaggguucguuauuugaugagggugcgccauaucagcuaguuggugggguaacggccuaccaaggcaaugacguguagcuaugcugagaaguagaauagccacaaugggacugagacacggcccauacuccuacgggaggcagcaguagggaauuuuucacaaugagcgaaagcuugauggagcaaugccgcgugaacgaugaaggucuuuaagauuguaaaguucuuuuauuugggaagaaugacuuuagcagguaauggcuagaguuugacuguaccauuuugaauaagugacgacuaacuaugugccagcagucgcgguaauacauaggucgcaagcguuauccggauuuauugggcguaaagcaagcgcaggcggauugaaaagucugguguuaaaggcagcugcuuaacaguuguaugcauuggaaacuauuaaucuagagugugguagggaguuuuggaauuucauguggagcggugaaaugcguagauauaugaaggaacaccaguggcgaaggcgaaaacuuaggccauuacugacgcuuaggcuugaaaguguggggagcaaauaggauuagauacccuaguaguccacaccguaaacgauagauacuagcugucggggcgauccccucgguagugaaguuaacacauuaaguaucucgccuggguaguacauucgcaagaaugaaacucaaacggaauugacggggacccgcacaagugguggagcauguugcuuaauucgacgguacacgaaaaaccuuaccuagacuugacauccuuggcaaaguuauggaaacauaaugccgagugacagguggugcaugguugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuuaucguuaguuacauugucuagcgagacugcuaaugcaaauuggaggaaggaagggaugacgucaaaucaucaugccccuuaugucuagggcugcaaacgugcuacaauggccaauacaaacagucgccagcuuguaaaagugagcaaaucuguaaaguuggucucaguucggauugagggcugcaauucguccucaugaagucggaaucacuaguaaucgcgaaucagcuaugucgcggugaauacguucucgggucuuguacacaccgcccgucaaacuaugaaagcugguaauauuuaaaaacguguugcuaaccauuaggaagcgcaugucaaggauagcaccggugauuggaguuaagucguaacaagguaccccuacgagaacguggggguggauca .....<<<<..[.(((..>>>>.<<<<.<<<<...<<<<<<<<.....<<<.<<<..<<<..<<.<<<<<<....>>>>>>.>>>>>......<<........<<<<<<<..<<.......<<<.<.<<..<..<<<<<......>>>>>.....>>>.>.....<<<<<<<.<<.>>..>>>>>>>....<<<<<<....>>>>>>.>>>......>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<............>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<.....>>>>.....>>>>.......<<<...<...<<<<<<<<<........>>>>>>>>>...>....>>>..........<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>...>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<..<<<<<<<<<<.....<<<<<<<.....>>>>>>>..>>>>>>>..>>>.>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<<..<<<......>>>.....>>>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<......>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<.....<<<<<....>>>>>...>>>....))).]<<<<<.<<<<<<<.<<..<<<<...<<<<<<<<<<......<<........>>..........<<<<<<.........<<<..........<......>.......>>>....<<<.<<<..<<<<<<.<.....<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<..<<<<<<<.........>>>>>>>.....<<<<......>>>>.........>>>.....>...>>>...>>>>>>>>>....>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>....>>>>>>>......<....<<<<<<<........>>>>>>>....>......>>>>.....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<..<<<<<....<<<<<<.<<<..<<....>>.>>>>>>>>>...>>>>>..>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .....((((..[..[[..)))).((.(...((.(.((.(.((((....(((..((..(((..((..(((((....)))).).)))))........(.......(((((((..((...(..(((..(.((.....((((((....))))))......)).).....((.((((........)))).))....(.(((......))).)..)))..)..))))))))).((.....(((..((.(..((.......))...)))))).......))..(((((.((....)).)...)))))...(((((............))))).((((....))))...)).))).).....(.(((...(((((....)))).))))).)).).).))..((((......((((.....)))).....)))).......(((...(....(((.((((........)))).)).)...)....)))..........(.((([[[...(((((.....((.]]])).......)))))))).)..)))..).))..........((([[...(.((((....((.(((((...(((((.((((......((((((.....))))))...)))).)))..))..)))))..((((.(((....((((((((....(((((((...((........))......)))))))....).......((....)).)))))))...)))..)))..)))....))))....((((((...((...((((.........))))...))))))))......{...((((((..((((.((.((......)).)).))))...((..]])).....)))))))))).(((.......(((....))).....)))....]]..](((((.(((((((.....(((.....(((((.((.(.....((........))........(.(((..(.......((...........(..(....)...)........))..((.((....((((((.(....(((((((((....)))...(((......)))...)))))).....((.(.((((..(.........)..))))..(..(((.(....).))).....)..).)).....).).)))...))..)))).....)..))))..)).).)))))..(...(.(((((.....(((..(((.((((....))))).))....)))....))))).)......(....(((((((........)))))))....)..)....))).....(((((((.(.....)..)))))))...........)))))))))).))..(.(..((.(.((((.(((..((((((..(((.(....((((((.(((..((....)).)))))))))...).)))..))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... 70S ribosome with EF-G, A/P- and P/E-site tRNAs in pseudouridimycin-treated Mycoplasma pneumoniae cells; 16S ribosomal RNA 7pit 7 76 5.7 RF00005 URS000054164D_272634 36171285 0030533 0006412 272634 ggucuuguagcucagucgguagagcaacggucugaagaaccgugugucggcaguucgauucugcccgagaccacca <<<<<<...<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>.>>>>>>.... (((((((..((.(........).))..((((.......))))......(((((.......)))))))))))).... 70S ribosome with EF-G, A/P- and P/E-site tRNAs in pseudouridimycin-treated Mycoplasma pneumoniae cells; tRNA-Phe 7pit 8 76 5.7 RF00005 URS000054164D_272634 36171285 0030533 0006412 272634 ggucuuguagcucagucgguagagcaacggucugaagaaccgugugucggcaguucgauucugcccgagaccacca <<<<<<...<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>.>>>>>>.... (((((((..((.(........).))..((((.......))))......(((((.......)))))))))))).... 70S ribosome with EF-G, A/P- and P/E-site tRNAs in pseudouridimycin-treated Mycoplasma pneumoniae cells; tRNA-Phe 7pjs A 2903 2.35 RF02540,RF02541 URS00021ED929_562 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaacccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccgggagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<<..>>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<.........>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<.<<<....................................<......>....>>>.>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<..........>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<.<..<<<............<<<................<<<<<....>>>>>.......................>>>...>>>..>.>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[......(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))..(((((((..((((((((((.....(((...(((.((((...((.((.(.....).))..))...)))).)))..)).).....)))))).)))..)))))))).....(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((.(......(.............)..............((......))...).)))...)))..))))).))...........]]].)...))))))))))...)))))))((((((..........))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]]((((((((((.((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..((((......))))...))))))...)))...))))(..).....))))...)).....)))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))((((...........))))........((.(......).(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((((((.(...(..............((.(...............(.(......).)......................).))......)...)))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Structure of the 70S ribosome with tRNAs in the classical pre-translocation state and apramycin (C); 23S ribosomal RNA 7pjs B 120 2.35 RF00001 URS0000049E57_562 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Structure of the 70S ribosome with tRNAs in the classical pre-translocation state and apramycin (C); 5S ribosomal RNA 7pjs a 1540 2.35 RF00177,RF01959,RF01960 URS00000ABFE9_562 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggaucaccuccu ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<..........>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<.<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>....<....>...>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>..>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<..<.<<<<<<<........>>>>>>>>...>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((.(((..........)))..)))))..)))))......(((......(((((((..((...(((((((...((.....((((((....))))))......)).......(((....)))....((((.(..((....))).)))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....(.((((.(.......).)))).).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.(((((((.((......((((((.....))))))....)).)))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))...........(.((((..(...(((((((..(((((((....)))))))....(....)...))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))).)....)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....((..(............)..))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Structure of the 70S ribosome with tRNAs in the classical pre-translocation state and apramycin (C); 16S ribosomal RNA 7pjs v 77 2.35 RF00005 URS00001BBAFC_562 0030533 0006412 562 cgcggggnggagcagccuggnagcucgucgggcucauaacccgaagaucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Structure of the 70S ribosome with tRNAs in the classical pre-translocation state and apramycin (C); P-site tRNA(fMet) 7pjs w 76 2.35 RF00005 URS00021ED99D_562 0030533 0006412 562 gcccgganagcucagucgguagagcaggggauugaanauccccgunuccucggnucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((.........)))).....(((((..]....)))))))))))).... Structure of the 70S ribosome with tRNAs in the classical pre-translocation state and apramycin (C); P-site fMet-Phe-tRNA(Phe) 7pjs z 11 2.35 562 acuauguuugu ........... ........... Structure of the 70S ribosome with tRNAs in the classical pre-translocation state and apramycin (C); mRNA 7pjt A 2902 6.0 RF02540,RF02541 URS00021ED929_562 34635670 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaacccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccgggagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<................>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<.<<<......<.............>...........................>>>.>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<..........>>>>>>....>>>>>><<<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>.>>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....[[....>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<....<<..>>.....>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.......<<<<<<.<<....>>..>>>>>>.......>>>>>>>>>..>>>>><<.<...........>.>>.......<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<..<<<.<<<<<.<<<<<<<<<<..<<<............<<.................<..<<....>>..>........................>>...>>>..>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>...>>>>..<<<<.....>>>><<<<<<...........>>>>>>.(<<...<<<<<<<...<<<<<<.......>>>>>>.....<<)..(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<.<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>...>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.]].>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((.......(((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((.(((...(((]]]..].))).......))).))...)))....(((....)))(((((((....))))))).((((((((...........)))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((.((((((.((.(((...(((.(......).)))[[......(((.....]])))...)))...)).)))))).)))...))))...).....(((.(((..[......))).))).......((.((].[[[[)).))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))......(.(.((...((((((..))))))...)).)...(.(........).).((((((....(((((.(((((((..((....((.....))....))...((....))..((((.....)))).....))))))).)))))..((.(...((((((.....((((((..((.(((....((((.(......).))))....[)))...(((.(((((.......<))))))))..).)..)))))).(.((.......))...)..))))))......).))..((((((....(((((....)))))..(((((((..(((.((((((.....(((...(((.((((...(((.(.........).).))...)))).)))..)).).....))))))..))..)))))))).....(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(.(.....{.(((((......(.............)..............((......))...)))))...).)..))))).))...........]]].)...))))))))))...)))))))((((.(..........).))))....))))))(.(((((...(((.......(.((((......)))).)....)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))...((((........)))).]](((.(((((((((...(.((....((((..(((..(((((.((((((...{{..).))))).(...((((...(((((.((((((.((.....)))))))).)..))))..[))))....)(..(((((....)))))...))))))...)))...))))(..).....)).)...))....))))))).))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....))))).(((((......((....((((..)])))....))....))))).(...).......(((((..((.].((.........))...(((((((.....(.(....).).......))))))).}((((.(((..(((((((..((.........((.(...((....))....).)).........)))))))..))))).(.(...........)..).......((..........(((((.......)))))..)..)....))))...))...))))).)..))).)))))))).)))))).....)).[..(((((......].)))))..((((((((.(((.((......((((.((((((..(((((.((..(((.(.((((((.(.(..((............................................................................))...)).))))))...(((.((((((.....)))))))))....).)))..))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][..[[))....)))))).)..((((..(((...{..)))..)))).(((....))).))]]..].....((.((((.((..]]]]..)))))).)).....)}......))))..))))))......(.((..(.((((((...((.......))...))))))...).))...).....((.((.((((((..((((((.(........).)))..))).(((((.....))))).....)))))..)...))..))....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))..)))))...)))).)))))....((....((((.....}.......))))....))..))))..]....)))))))(.((((((..).)))))(....((..(((.(.......).)))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Structure of the 70S ribosome with tRNAs in hybrid state 1 (H1); 23S ribosomal RNA 7pjt B 120 6.0 RF00001 URS0000049E57_562 34635670 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.....<.<<<<<<<<...>>>>>>>>...>...>>...>>>>>>>>>>. ((((((((.(.....((((((.(....(((((((...(.....)...))))..)))...).)))).)).((.......((((((((...)))))))).......))...).)))))))). Structure of the 70S ribosome with tRNAs in hybrid state 1 (H1); 5S ribosomal RNA 7pjt a 1540 6.0 RF00177,RF01959,RF01960 URS00000ABFE9_562 34635670 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggaucaccuccu ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<............>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<...<<.....<<<<<......>>>>>......>>.......<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<.......<<<....>>>......>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<.....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>..>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<.<......<<........>>..........<<<<<<<.......<<<<<<.....<<<......>>>................>>>>>.>..<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>..>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>.......<<...<<<<.<<...<<<<<<<.<<<<....<<<<<<.<<<...<<....>>..>>>>>>>>>...>>>>.>>>>>>>...>>.>>>>....>>.........<<<<<<<<<....>>>>>>>>>............ ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(.(..((.((..(((.((............))..)))))..))).)......(((......(((((((..((...(.(((((...((.....((((.(....).))))......)).......(((....)))....(((..(..((....)))..))).))))).)..)).)))))))(((....((...((((((((.......)))))))).))......)))..((((((((....))))...))))))).(((((.(.........)))))).((((....))))...)))))).).....(.(((...(.(((....)))..))))).)).))))))..(((........(((....))).......)))..((.(((((...(....(.(.((.(.......).)).).).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((....((.(.((((..(((((((.((......((((((.....))))))....)).)))))..)).)))).)..(((((((((....(((((((....(((((((...((........))......)))))))....).......((....)).))))))...))).)))))..)))....))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((..(((((.....)))))..)))))...((..]])).....)))))))))).(.(......(.((....))).....).)...]]].]((((..(((((((.((..(((.(..((((((((((......((........))..........(((((((..(...(((((((....(((((....)))))...............))))).))).((.(((...((((((.(....((((((.((....))....(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(.((((......(((..((...(((....)))...))....)))......)))).)......(....(((((((........)))))))....)..)..).))).....(.(((((.........))))).)......))...))))))).)).))..(.(..((.(.((((.(.(...((.((..((((....(((((..((((..((....)).)))).)))))...))))..)).))...).).))))..).))...)..)..(((((((((....)))))))))}........... Structure of the 70S ribosome with tRNAs in hybrid state 1 (H1); 16S ribosomal RNA 7pjt v 77 6.0 RF00005 URS00001BBAFC_562 34635670 0030533 0006412 562 cgcggggnggagcagccuggnagcucgucgggcucauaacccgaagaucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Structure of the 70S ribosome with tRNAs in hybrid state 1 (H1); P-site tRNA(fMet) 7pjt w 76 6.0 RF00005 URS00021ED99D_562 34635670 0030533 0006412 562 gcccgganagcucagucgguagagcaggggauugaanauccccgunuccucggnucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((.........)))).....(((((..]....)))))))))))).... Structure of the 70S ribosome with tRNAs in hybrid state 1 (H1); P-site fMet-Phe-tRNA(Phe) 7pjt z 11 6.0 34635670 562 acuauguuugu ........... ........... Structure of the 70S ribosome with tRNAs in hybrid state 1 (H1); mRNA 7pju A 2903 9.5 RF02540,RF02541 URS00021ED929_83333 34635670 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaacccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccgggagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<<..>>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<...........>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<...........<<................................................>>.......>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<.<<....>>.>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<..<<....>>...>>>>>........>>>>>>>>..>>>>><<.<............>.>>.......<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<....<<<............<<.................<<<<<....>>>>>........................>>...>>>....>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......((((((((((.((.(((...(((((......)))))[[......(((.....]])))...)))...)).))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))..(((((((..((((((((((.....(((...(((.((((...(((.(.........).).))...)))).)))..)).).....)))))).)))..)))))))).....(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(.(((..(((.....{...(((......(.............)..............((......))...))).....)))..))).).))...........]]].)...))))))))))...)))))))((((((..........))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]]((((((((((.((...((((....((((..(((..(((((.((((((...{{{.).))))).((..((((....((((.((((((.((.....)))))))).)..)))...[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...)).....)))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..))))).(.(............)..).......((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((((((.(..(..........[....((.(...............(.(......).)............].........).))......)...)))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).).....((.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..))....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Structure of the 70S ribosome with tRNAs in hybrid state 2 (H2); 23S ribosomal RNA 7pju B 120 9.5 RF00001 URS0000049E57_83333 34635670 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((.(((((....(((((((...(.....)...))))..)))...)))))..)).((.......((.(((((...))))).)).......))...)))))))))). Structure of the 70S ribosome with tRNAs in hybrid state 2 (H2); 5S ribosomal RNA 7pju a 1540 9.5 RF00177,RF01959,RF01960 URS00000ABFE9_83333 34635670 0003735 0005840 83333 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggaucaccuccu ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<............>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<....<<<<......>>>>...............>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<...<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>...>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((.((............))..)))))..)))))......(((......(((((((..((...(((((((...((.....((((((....))))))......)).......(((....)))....((((.(..((....))).)))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....(.((((.(.......).)))).).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.(((((((.((......((((((.....))))))....)).)))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((.((((.....)))).)))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((....(((((....)))))...............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(.....((((((........)))))).....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((...((.((..((((....((((((.((((..((....)).))))))))))...))))..)).))...))).))))..).))...)..)..(((((((((....)))))))))}........... Structure of the 70S ribosome with tRNAs in hybrid state 2 (H2); 16S ribosomal RNA 7pju v 77 9.5 RF00005 URS00001BBAFC_83333 34635670 0030533 0006412 83333 cgcggggnggagcagccuggnagcucgucgggcucauaacccgaagaucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Structure of the 70S ribosome with tRNAs in hybrid state 2 (H2); P-site tRNA(fMet) 7pju w 76 9.5 RF00005 URS00021ED99D_83333 34635670 0030533 0006412 83333 gcccgganagcucagucgguagagcaggggauugaanauccccgunuccucggnucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((.........)))).....(((((..]....)))))))))))).... Structure of the 70S ribosome with tRNAs in hybrid state 2 (H2); P-site fMet-Phe-tRNA(Phe) 7pju z 11 9.5 34635670 83333 acuauguuugu ........... ........... Structure of the 70S ribosome with tRNAs in hybrid state 2 (H2); mRNA 7pjv A 2903 3.1 RF02540,RF02541 URS00021ED929_83333 34635670 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaacccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccgggagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<<..>>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<...........>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<.........<<<<................................................>>>>.....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<.<<....>>.>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<<.<<....>>..>>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<.<<.<<<............<<<..............<.<<<<<....>>>>>.>.....................>>>...>>>.>>.>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.<...<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>>....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((....[[[.))).....((((((...(((]]]....))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......((((((((((.((.(((...(((((......)))))[[......(((.....]])))...)))...)).))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))..(((((((..((((((((((.....(((...((..((((...(((.(.........).).))...))))..))..)).).....)))))).)))..)))))))).....(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(.(.....{...(((......(.............)..............((......))...))).....).)..))))).))...........]]].)...))))))))))...)))))))((((((..........))))))....))))))(.(((((...(((......(((((((......)))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]]((((((((((.((...((((....((((..(((..(((((.((((((...{{{.).))))).((..(((....((((((((((((.((.....))))))))))..))))..[.)))...))(..(((((....)))))...))))))...)))...))))(..).....))))...)).....)))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((....((((..)])))....)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))((((...........))))........((.(......).(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((((((....((..............(..(....(.........(..(......)..)......)..............)..).....))....))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).).....((.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..))....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Structure of the 70S-EF-G-GDP-Pi ribosome complex with tRNAs in hybrid state 1 (H1-EF-G-GDP-Pi); 23S ribosomal RNA 7pjv B 120 3.1 RF00001 URS0000049E57_83333 34635670 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((.(((((....(((((((...(.....)...))))..)))...)))))..)).((.......((((((((...)))))))).......))...)))))))))). Structure of the 70S-EF-G-GDP-Pi ribosome complex with tRNAs in hybrid state 1 (H1-EF-G-GDP-Pi); 5S ribosomal RNA 7pjv a 1540 3.1 RF00177,RF01959,RF01960 URS00000ABFE9_83333 34635670 0003735 0005840 83333 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggaucaccuccu ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<............>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<.......<<<....>>>......>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<.....<<<<....>>>>................>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((............))).)))))..)))))......(((......(((((((..((...(((((((..(((.....((((((....))))))......)).).....(((....)))....((((.(..((....))).)))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..(((........(((....))).......)))..((.(((((...(....(.((((.(.......).)))).).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.(((((((.((......((((((.....))))))....)).)))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((.((((.....)))).)))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].]((((..(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((....(((((....)))))...............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...))))))).)).))..(.(..((.(.((((.(((..((((((.(((((....((((((.((((..((....)).))))))))))...))))).))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Structure of the 70S-EF-G-GDP-Pi ribosome complex with tRNAs in hybrid state 1 (H1-EF-G-GDP-Pi); 16S ribosomal RNA 7pjv v 77 3.1 RF00005 URS00001BBAFC_83333 34635670 0030533 0006412 83333 cgcggggnggagcagccuggnagcucgucgggcucauaacccgaagaucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Structure of the 70S-EF-G-GDP-Pi ribosome complex with tRNAs in hybrid state 1 (H1-EF-G-GDP-Pi); P-site tRNA(fMet) 7pjv w 76 3.1 RF00005 URS00021ED99D_83333 34635670 0030533 0006412 83333 gcccgganagcucagucgguagagcaggggauugaanauccccgunuccucggnucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((.........)))).....(((((..]....)))))))))))).... Structure of the 70S-EF-G-GDP-Pi ribosome complex with tRNAs in hybrid state 1 (H1-EF-G-GDP-Pi); P-site fMet-Phe-tRNA(Phe) 7pjv z 11 3.1 34635670 83333 acuauguuugu ........... ........... Structure of the 70S-EF-G-GDP-Pi ribosome complex with tRNAs in hybrid state 1 (H1-EF-G-GDP-Pi); mRNA 7pjw A 2903 4.0 RF02540,RF02541 URS00021ED929_562 34635670 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaacccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccgggagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<<..>>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<................>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<...........<<................................................>>.......>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<.<......>.>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<.<.<<<...<<<....>>>...>>>..>>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<..<<....>>...>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<....<<.............<<<<<..............<.<<<....>>>.>.....................>>>>>....>>....>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((.......(((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((..((((((((.(((...(((.(......).)))[[......(((.....]])))...)))...))))))))..)))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))......(.((((..(((((((..)))))))..))))...(.(........).).((((((....(((((((((((.(..((....((.....))....))...((....))..((((.....)))).....).)))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((.(.........).).))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{..((((......(.............)..............((......))...))))....)))..))))).))...........]]].)...))))))))))...)))))))((((((.((....)).))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((.(((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..(((....((((((((((((.((.....))))))))))..))))..[.)))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))).))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((....((((..)])))....)))...))))))(...).......((((((.((.].((.........))...(((((((.....(((....))).......))))))).}((((..((..(((((((..(((........((((...((....))....))))........))))))))..))))....(...........)...........((..........(((((.......)))))..)..)....))))...))..)))))).)..))).)))))))).)))))).....)).[..(((((......].)))))..(((.((((.(((.((......((((.((((((..(((((.(((.(((((.((((((((.(..(..................(...............(..........)......................).........)...)))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((....((((((...(((((.........))))).....((][.[[[))....))))))....((((..((((..{.))))..)))).(((....))).))]]].].....((.((((.((..]]]]..)))))).)).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..((((((.((......)).)))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..))))))).)))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Structure of the 70S-EF-G-GDP-Pi ribosome complex with tRNAs in hybrid state 2 (H2-EF-G-GDP-Pi); 23S ribosomal RNA 7pjw B 120 4.0 RF00001 URS0000049E57_562 34635670 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((.(((((....(.(((((...(.....)...))))..).)...)))))..)).((.......((.(((((...))))).)).......))...)))))))))). Structure of the 70S-EF-G-GDP-Pi ribosome complex with tRNAs in hybrid state 2 (H2-EF-G-GDP-Pi); 5S ribosomal RNA 7pjw a 1540 4.0 RF00177,RF01959,RF01960 URS00000ABFE9_562 34635670 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggaucaccuccu ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<............>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<.<.<<<..>>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<.......<<<<..>>>>......>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>.>..........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<.....<<<<....>>>>................>>>>>.>>..<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>....>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<..<.<.<<<<<<<<<<<<....<<<<<<.<<<...<<....>>..>>>>>>>>>...>>>>>>>>>>>>..>>..>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((.((............))..)))))..)))))......(((.......((((((..((...(((((((...((.....((((.(....).))))......)).......(((....)))....(((..(..((....)))..))).)))))))..)).)))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((.......(((....)))......))))..((.(((((...(....(.((((.(.......).)))).).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.(((((((.((......((((((.....))))))....)).)))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((.(((.....))).))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((....(.(((....))).)...............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....(((..(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)...))).....).).)))...)).)))))....)))))))...)).)))))))).(...(.(((((.....(((..((...(((....)))...))....))).....))))).)......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((...((((((..(((....((((((.((((..((....)).))))))))))...)))..))))))...))).))))..).))...)..)..(((((((((....)))))))))}........... Structure of the 70S-EF-G-GDP-Pi ribosome complex with tRNAs in hybrid state 2 (H2-EF-G-GDP-Pi); 16S ribosomal RNA 7pjw v 77 4.0 RF00005 URS00001BBAFC_562 34635670 0030533 0006412 562 cgcggggnggagcagccuggnagcucgucgggcucauaacccgaagaucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Structure of the 70S-EF-G-GDP-Pi ribosome complex with tRNAs in hybrid state 2 (H2-EF-G-GDP-Pi); P-site tRNA(fMet) 7pjw w 76 4.0 RF00005 URS00021ED99D_562 34635670 0030533 0006412 562 gcccgganagcucagucgguagagcaggggauugaanauccccgunuccucggnucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((.........)))).....(((((..]....)))))))))))).... Structure of the 70S-EF-G-GDP-Pi ribosome complex with tRNAs in hybrid state 2 (H2-EF-G-GDP-Pi); P-site fMet-Phe-tRNA(Phe) 7pjw z 11 4.0 34635670 562 acuauguuugu ........... ........... Structure of the 70S-EF-G-GDP-Pi ribosome complex with tRNAs in hybrid state 2 (H2-EF-G-GDP-Pi); mRNA 7pjx A 2903 6.5 RF02540,RF02541 URS00021ED929_562 34635670 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaacccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccgggagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<<..>>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<...........>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<.........<<<<................................................>>>>.....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<.<<....>>.>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<<.<<....>>..>>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<.<<.<<<............<<<..............<.<<<<<....>>>>>.>.....................>>>...>>>.>>.>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.<...<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>>....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((....[[[.))).....((((((...(((]]]....))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((.((((((.((.(((...(((((......)))))[[......(((.....]])))...)))...)).)))))).)))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))..(((((((..((((((((((.....(((...((..((((...((..(.........)...))...))))..))..)).).....)))))).)))..)))))))).....(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(.(.....{...(((......(.............)..............((......))...))).....).)..))))).))...........]]].)...))))))))))...)))))))((((((..........))))))....))))))(.(((((...(((......(((((((......)))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]]((((((((((.((...((((....((((..(((..(((((.((((((...{{{.).))))).((..(((....((((((((((((.((.....))))))))))..))))..[.)))...))(..(((((....)))))...))))))...)))...))))(..).....))))...)).....)))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((....((((..)])))....)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........((.((..((....))...)).))........))))))))..)))))((((...........))))........((.(......).(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((((((....((..............(..(....(.........(..(......)..)......)..............)..).....))....))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).).....((.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..))....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Structure of the 70S-EF-G-GDP ribosome complex with tRNAs in hybrid state 1 (H1-EF-G-GDP); 23S ribosomal RNA 7pjx B 120 6.5 RF00001 URS0000049E57_562 34635670 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((.(((((....(((((((...(.....)...))))..)))...)))))..)).((.......((((((((...)))))))).......))...)))))))))). Structure of the 70S-EF-G-GDP ribosome complex with tRNAs in hybrid state 1 (H1-EF-G-GDP); 5S ribosomal RNA 7pjx a 1540 6.5 RF00177,RF01959,RF01960 URS00000ABFE9_562 34635670 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggaucaccuccu ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<............>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<.......<<<....>>>......>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<....<<<<<....>>>>>...............>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<.<.<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((............))).)))))..)))))......(((......(((((((..((...(((((((..(((.....((.((......)).))......)).).....(((....)))....((((.(..((....))).)))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..(((........(((....))).......)))..((.(((((...(....(.((((.(.......).)))).).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.(((((((.((......((((((.....))))))....)).)))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((.((((.....)))).)))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].]((((..(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((....(.(((....))).)...............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...))))))).)).))..(.(..((.(.((((.(.....((.((.(((((....((((((.((((..((....)).))))))))))...))))).)).)).....).))))..).))...)..)..(((((((((....)))))))))}........... Structure of the 70S-EF-G-GDP ribosome complex with tRNAs in hybrid state 1 (H1-EF-G-GDP); 16S ribosomal RNA 7pjx v 77 6.5 RF00005 URS00001BBAFC_562 34635670 0030533 0006412 562 cgcggggnggagcagccuggnagcucgucgggcucauaacccgaagaucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Structure of the 70S-EF-G-GDP ribosome complex with tRNAs in hybrid state 1 (H1-EF-G-GDP); P-site tRNA(fMet) 7pjx w 76 6.5 RF00005 URS00021ED99D_562 34635670 0030533 0006412 562 gcccgganagcucagucgguagagcaggggauugaanauccccgunuccucggnucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((.........)))).....(((((..]....)))))))))))).... Structure of the 70S-EF-G-GDP ribosome complex with tRNAs in hybrid state 1 (H1-EF-G-GDP); P-site fMet-Phe-tRNA(Phe) 7pjx z 11 6.5 34635670 562 acuauguuugu ........... ........... Structure of the 70S-EF-G-GDP ribosome complex with tRNAs in hybrid state 1 (H1-EF-G-GDP); mRNA 7pjy A 2903 3.1 RF02540,RF02541 URS00021ED929_83333 34635670 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaacccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccgggagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<.............>...>>..........<......>....>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<..........>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<<.<<....>>..>>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<..................................<<.<<......>>.>>................................>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[......(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..((....((.....))....))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.((.......))...)..))))))......).))..((((((....(((((....)))))..(((((((..((((((((((.....(((...(((.((((....((((((.....))))).)....)))).)))..)).).....)))))).)))..)))))))).....(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((.((..(((.....{..((((......(.............)..............((......))...))))....)))..)).)).))...........]]].)...))))))))))...)))))))((((((..........))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]]((((((((((.((...((((....((((..(((..(((((.((((((...{{{.).))))).((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(...((((....))))....))))))...)))...))))(..).....))))...)).....)))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((((..(.(..(.................(...(.........(...(......)...)......).............).........).).)..))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(.(((((.....(....)....))))).).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Structure of the 70S-EF-G-GDP ribosome complex with tRNAs in chimeric state 1 (CHI1-EF-G-GDP); 23S ribosomal RNA 7pjy B 120 3.1 RF00001 URS0000049E57_83333 34635670 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((.(.....((.(((((....(((((((...(.....)...))))..)))...)))))..)).((.......((.(((((...))))).)).......))...).)))))))). Structure of the 70S-EF-G-GDP ribosome complex with tRNAs in chimeric state 1 (CHI1-EF-G-GDP); 5S ribosomal RNA 7pjy a 1540 3.1 RF00177,RF01959,RF01960 URS00000ABFE9_83333 34635670 0003735 0005840 83333 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggaucaccuccu ........<<<<...[((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<..........>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<...<<.....<<<<<......>>>>>......>>.......<<<....>>>....<<<<..............>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>..<<.<<<<<......<.<<<<<<...........>>>>>>.>........>>>>>....>>.<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<.<<<<<.....>>>>>.>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<....>>>>>>..............>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<.<<....>>...<<<<......>>>>..>>>>>>.....<<<..<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>.........>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ ........((((....[[[..)))).(((..(((((..(((((((((....(((.(((..(((..((.((..(((((((..........)))).)))))..)))))......(((......(((((((..((...(((((((...((.....((((((....))))))......)).......(((....))).....(((..............)))..)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..(((.......((((....))))......)))..((.(((((...(...((.(((..(.......)..))).).)...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..))))).)))..........((([[...(.((((...(((.(((((((.(((((((.((......((((((.....))))))....)).)))))..)))))))))..(((((((((....(((((((....(((((((...((........))......)))))))....).......((....)).))))))...)))).))))..))))...))))....((((((....(...((((.........))))...).))))))......{...((((((..(((((((.((((.....)))).)))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]]..(((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...((((((....))))))..............))))).))).((.(((...((((((.(....((((((.((....))....(((......)))...)))))).....((((.(((((((...((..(.(......))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((.((((((((....((((((.((((..((....)).))))))))))...)))))))).)))..))).))))..).))...)..)..(((((((((....)))))))))}........... Structure of the 70S-EF-G-GDP ribosome complex with tRNAs in chimeric state 1 (CHI1-EF-G-GDP); 16S ribosomal RNA 7pjy v 77 3.1 RF00005 URS00001BBAFC_83333 34635670 0030533 0006412 83333 cgcggggnggagcagccuggnagcucgucgggcucauaacccgaagaucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Structure of the 70S-EF-G-GDP ribosome complex with tRNAs in chimeric state 1 (CHI1-EF-G-GDP); P-site tRNA(fMet) 7pjy w 76 3.1 RF00005 URS00021ED99D_83333 34635670 0030533 0006412 83333 gcccgganagcucagucgguagagcaggggauugaanauccccgunuccucggnucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>><<<<<<<.....>>>>>>.>...<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((.........)))).....(((((..]....)))))))))))).... Structure of the 70S-EF-G-GDP ribosome complex with tRNAs in chimeric state 1 (CHI1-EF-G-GDP); P-site fMet-Phe-tRNA(Phe) 7pjy z 10 3.1 34635670 83333 uauguuuguu .......... .......... Structure of the 70S-EF-G-GDP ribosome complex with tRNAs in chimeric state 1 (CHI1-EF-G-GDP); mRNA 7pjz A 2903 6.0 RF02540,RF02541 URS00021ED929_562 34635670 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaacccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccgggagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<.<<......<<<<<<....(((.>>>.....<<<<<<<..<<.))).....>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<......>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<......<<<<<<<<<<.<..<<<...<<<<........>>>>(.......<<<......)>>>...>>>....>.>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..(((.>>>>>..>>>.......>.>>>>>>>.>>...............<<....>>....>>.........<<<<.....>>>>..................>>>>>>>>>>>.......<<<...<<<<<<....>>>>>>...>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<.<...<<<....<<<<<........>>>>>.....>>>...<<<.<<<<<........>>>>>>>>.....>.>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<................>>...>>>>.>>>..>>.>.....>>>>>>>.>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<.<<..<<..........<<<......<.............>...........................>>>......>>..>>.>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<..........>>>>>>....>>>>>>..<<<<<....<<..........<<<<....>>>>.......>>...>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<....<<.....>>..>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>...<<<<........>>>>.))<<<<<<<<<<.<<...<<<<....<<<<..<<<..<<<<<.<<<<<....[[....>>>>>.<...<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>....>...<<<<<....>>>>>....>>>>>...>>>...>>>>.........>>>>...>>.....>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<...........>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<..<......>...>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>....................<<<<<<.....>>>>>>..........>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.<<......<<<<.<<<<<<..<<<<..<<<.<<<<..<<<<<<..<<..<<...............................<..<.......>...>.............................>>..>>..>>>>>>...<<<.<<<<<<.....>>>>>>>>>.....>>>>.>>>...>>>>..<<<<.....>>>><<<<<<...........>>>>>>.(<<...<<<<<<<...<<<<<<.......>>>>>>.....<<)..(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<.......))).....>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<.<<<...<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>.......>>>..>....<<<<<<<....>>>.>>>>....>>..>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<....<<<...<<<<.<<<<<..]]..>>>>>...>>>>...>>>..>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[......(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....((((.((((((((..((....((.....))....))...((....))..((((.....)))).....)))))))).))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((................))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((.((..(((.....{.(((((...................................((......))...)))))...)))..)).)).))...........]]].)...))))))))))...)))))))((((((..........))))))....))))))(.(((((....((......((((((((....))))))))...))...)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))....(((........)))..]](((((((((((((...((((....((((..(((..(((((.((((((...{{{.).))))).((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((........)))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(............(((((....(.{..).....)))))((((((.....(((....((((..)])))....)))...))))))(...).......(((((((((.].((.........))....((((((.....(((....))).......))))))..}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).)))))))....))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((.(.(..(.................(...(........((..............)).....).............).........).).).)))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....((((((..((..]]]]..)).)))))).....)}......))))..))))))......(.((..(.((((((...((.......))...))))))...).))...)......(.((.((((((..((((((.((......)).)))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Structure of the 70S-EF-G-GDP ribosome complex with tRNAs in chimeric state 2 (CHI2-EF-G-GDP); 23S ribosomal RNA 7pjz B 120 6.0 RF00001 URS0000049E57_562 34635670 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Structure of the 70S-EF-G-GDP ribosome complex with tRNAs in chimeric state 2 (CHI2-EF-G-GDP); 5S ribosomal RNA 7pjz a 1540 6.0 RF00177,RF01959,RF01960 URS00000ABFE9_562 34635670 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggaucaccuccu ........<<<<....((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<......<<.<..............>..>>.....>>>>>......<<.......<<<<<<<..<<...<<<<<<<...<<.....<<............>>......>>.......<<<....>>>....<<<<..............>>>>.>>>>>>>..>>.>>>>>>><<<....<<<...<<<<<<.........>>>>>>.>>>......>>>..<<<<<<<<....>>>...>>>>>.>>.<<<<<............>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<.......<<<....>>>......>>>>..<...<<<<......<.<<<<<............>.>>>>.>........>>>>......>.<<<<<(((...<<<<<........))).........>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<.....<.<<<<<<.....>>>>>>.>...>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<....<<<......>>>.......>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<..<<<<.....>>>>..>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<.......<<<....>>>.....>>>..))))..<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<........<<........>>..........<<<<<<<......<<<<<<<...<<<<<......>>>>>..............>>>>>.>>..<<.<<<..<<<<<<.<.....<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<....<.......>..>....>>>>>>>.....<<<<<.....>>>>>........>>>>.....>...>>>...>>>>>>>>....>>>>>>>......>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>.....<<<<<<.........>>>>>>.......>>...>>>>>>>>>>.>>....<..<<...<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<...<<....>>..>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>....>>...>.....<<<<<<<<<....>>>>>>>>>............ ........((((....[[[..)))).(((..(((((..(((((((((....(((.(((..(((..((.((..(((((((..........)))).)))))..)))))......(((.......((((((..((...(((((((...((.....((((........))))......)).......(((....))).....(((..............)))..)))))))..)).)))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....(.(((.............))).).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..))))).)))..........((([[...(.((((...(((.(((((((.(((((((.((......((((((.....))))))....)).)))))..)))))))))..(((((((((...((((((.(....(((((((...((........))......)))))))....).......((....))..))))))..)))).))))..))))...))))....((((((....(...((((.........))))...).))))))......{...((((((..(((((((.((((.....)))).)))))))...((..]])).....)))))))))).(((......(.((....)).)....)))...]]]..(((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...((((((....))))))..............))))).))).((.(((...((((((.(....((((((.((....))....(((......)))...)))))).....((((.(((((((...((..(.(.....).)))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Structure of the 70S-EF-G-GDP ribosome complex with tRNAs in chimeric state 2 (CHI2-EF-G-GDP); 16S ribosomal RNA 7pjz v 77 6.0 RF00005 URS00001BBAFC_562 34635670 0030533 0006412 562 cgcggggnggagcagccuggnagcucgucgggcucauaacccgaagaucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>......<<<<.......>>>>.>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Structure of the 70S-EF-G-GDP ribosome complex with tRNAs in chimeric state 2 (CHI2-EF-G-GDP); P-site tRNA(fMet) 7pjz w 76 6.0 RF00005 URS00021ED99D_562 34635670 0030533 0006412 562 gcccgganagcucagucgguagagcaggggauugaanauccccgunuccucggnucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((.........)))).....((((...].....))))))))))).... Structure of the 70S-EF-G-GDP ribosome complex with tRNAs in chimeric state 2 (CHI2-EF-G-GDP); P-site fMet-Phe-tRNA(Phe) 7pjz z 10 6.0 34635670 562 uauguuuguu .......... .......... Structure of the 70S-EF-G-GDP ribosome complex with tRNAs in chimeric state 2 (CHI2-EF-G-GDP); mRNA 7pkq 1 93 4.2 URS0002681422_3055 3055 aaauuagaguuuggugcuggcucagcuuucaugcgccgagcggugguuuauacacaugcgagcuuaaggccacgagugcguaauacgcgaguu ......<<<<.........>>>>......................................<<<...>>>....................... ......((((.........))))......................................(((...)))....................... Small subunit of the Chlamydomonas reinhardtii mitoribosome; S1 rRNA 7pkq 4 415 4.2 RF00177,RF02542,RF01960,RF01959 URS0002681427_3055 0003735 0005840 3055 agcucuugcauugcugaauuuuuuuuuuuuuuuuuuuuuuaaaaaaaaaaaaaauuuuuuuuuuucaagucaucauggggcuuauagagugggcuacaggcguauuacauuggacacccacaaguugccaaaacuguccgaauauacggauuggaguaaaaaaaaaaaauuuuuuaaaauuuuuuuuuuuuuuugcugaaacuagccuccaugaagaaggaaucgcgaguaaucguagaucauuagcgcuacggugaagguaaccucuauugugcacacauugcccgucaccuccgauaauaguauuguacaggaagaacuauggcuacacuuagucgcggccuggaacguaugcgugauauuagaguuggaguaagucguaacagguugggguaggggaaccugcuccagaguc <<<.<<<..<<.<<<<<<......<<<<<<<<<<<<<....>>>>>>>>>>>>>.........>>>.>>>....>>>>>>>>.............................<<<<<..................>>>>>.......<....<<<<...<<<<<<<<<..<<<<..>>>>...>>>>>>>>>...<<........>>.>>>>....>...............<<<<<<<..........>>>>>>>...........................<..<<.<..<<<<<<<..<.<<<<<<<.<<....<..<<<.<<<<............>>>>>>>..>...>>.>>>>>>>.>..>>>>>>>...>.>>...>....<<<<<<<<<....>>>>>>>>>..... (((.(((...(.(((((.......((((((((((((((..))))))))))))))..........)).)))....).)))))).........................(...(((((..................))))).......(....(((((..((.(((((...((.(..).))....))))).))...((........)))))))....)..)............(((((((..........)))))))..............................((.(..(((.(((..(....(..(.((....(..((...((..............))..))..)...)).)..)....)..))).)))...).))........(((.(((((....))))).)))..... Small subunit of the Chlamydomonas reinhardtii mitoribosome; S4 rRNA 7pkq 2 213 4.2 RF00177 URS0002681423_3055 0003735 0005840 3055 ugcuaggugacccaauacgggcaucgggcaaaacucgcguaggauuagcgagcugggucgcuuuuuuuuuucagcggcccauggcuuauccuuagccugucuuaacgguacuaggccacgguggcacugaaaaggggccacgguucuuaugaacccagcaguguugaauuuuggacaaucgcuugaacggcggauccagaugcugcuuacaaa <<<<.<<<<.<<<.....>>>>>>>.>>>>..........<<<....<<....<<<<<<<..............>>>>>>>..>>....>>>..<<<...<<....>>.....>>>....<<<<<...........>>>>><<<<<....>>>>>.................<<<...<<<<<.....>>>>.>>>>................ (((..((((.(((.....)))))))..)))..........(((....((......(((((..............)))))....))....)))..((....((....))......))....(((((...........)))))(((((....)))))...............(.(((...(((((.....)))).)))))............... Small subunit of the Chlamydomonas reinhardtii mitoribosome; S2 rRNA 7pkq 3 393 4.2 RF00177,RF01959,RF02542,RF01960 URS0002681420_3055 0003735 0005840 3055 auuguuugaacaccccccaagcacgugccagaagggucgguaaaacgugcggugucaguauaaagcgucuugacuaggcaggcagcgcgucugagcgugugaacacuuuaaacguuggguaauauucggaggaucggucaaaugagaauauuccggauggaaagccgaaggcgaaagcaccaacaucagagucacuaaagcuucaacgcguaaguuuggguagcgaaccggauuagagacccggguaguccaaaccgucaacacauuauaguaaucuauaacgccuggugauacgguggcaacacuauaaaucaaagcaauuggcagcgauagagaugcgcgguggaauaugcuguuuaaaucgaauuuacgcgcaaaaucuuaccacuuuuu .........<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>.....................<<<.......<<<<...<<<....<...<<<<<..<.<<<<<....<<<<<<<<<..<<<......>>>.....>>>>>>>>>...........<<....>>.>>>>>.>.>>>>>...>...>>>...>>>>....<<<<<.<..<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<....>>>>>>.>>>.<<....<.<<<<....>>>>.>...>>.................................................<<........>>................... .........((((([[[...(((((.....((.]]])).......)))))))))).....................(((.....(.((((....((.....(..(((((..(.(((((.(.....(((((...((........))......))))).....)........((....)).))))).).)))))...)...))....))))....(((((....((...((((.........))))...)).)))))..........((((.(....).)))))))).(((.....((((....))))....))).................................................((........))................... Small subunit of the Chlamydomonas reinhardtii mitoribosome; S3 rRNA 7pkt 1 162 3.0 URS00023359C6_3055 34887394 3055 gggauugcugacugauagugcaaacaguacugugaaggaacuaaugaaacugggcuauaagugcgcauuccaccaauacgugagcauucgcgcauuaccauucuccagaggauuuaaaugcacaaaccuauaugccuuuuggcauaugauuacacuucguua <<<.<<<.<<...................<<....>>....<<<.....<<<<......<<<<<<<<...<<<......>>>.....>.>>>>>>>........>>>>.....>>>....>>>>>.>>>.<<<<<<....>>>>>>................ (((.(((..(.(.................((....))....(((.....((((......(.(((((..(((((......))).).)...))))).)........)))).....)))...)).))).))).((((((....))))))................ Large subunit of the Chlamydomonas reinhardtii mitoribosome; L1 rRNA 7pkt 2 86 3.0 URS00023359B5_3055 34887394 3055 cagcuauaauuuagcguaccuuuugcauuauggguuagcuacucaauagacgugaguuaagcagaaagcuuacugagauuuuuuua ..<<<<.....>>>>...<............>..........................<<<<.....>>>>............... ..((((.....))))...(.(........).)..........................((((.....))))............... Large subunit of the Chlamydomonas reinhardtii mitoribosome; L2a rRNA 7pkt 0 75 3.0 URS00023359BF_3055 34887394 3055 ggugcucggugaaaccgagcauccaauacuaaagaaacuuuacuggcuuaguacugggaccccauuuuuaguaua <<<<<<<<<<...>>>>>>>>>>..<<<<<<<<<<.......<<<<.......>>>>.......>>>>>>>>>>. (.(((.(((.....))).))).)..((((((((((.......(((((...)..)))).......)))))))))). Large subunit of the Chlamydomonas reinhardtii mitoribosome; L3a rRNA (5S) 7pkt 3 184 3.0 RF02541,RF02540 URS00023359B9_3055 34887394 0003735 0005840 3055 acgucuauuggacccgaaaccgaucgaucuagcgacgugcaggucugacuuuaaucaggaccgaacccgugucuguugcaagagacugggaugacacguggcuaggggugaaaggccaaucaaguucgguaauagcugguuuucugcgaaaucuauucagguaaagaguguguacuaagaccau ............<<.<...<<<<.<.....<<<.<<<<<..<<<<<<<......>>>>.>>>...<<<..<<<<........>>>>.>>>....>>>>>.>>>...<<<.....>>>......>.>>>>......>.>>............<.<<<....>>>.>................... ............((.(...((((.(.....(((.((((((.(((((((......)))).)))...(((..((((........)))).)))..).))))).))).(.(((.....)))...)..).))))......).))............(.(((....))).)................... Large subunit of the Chlamydomonas reinhardtii mitoribosome; L3b rRNA 7pkt 4 118 3.0 RF02541 URS00023359BD_3055 34887394 0003735 0005840 3055 auaccgguagcgcaagcgaaugguaauggaucuaauacaacacauucagacaaucggcgguaaggucaauugucaagaggagaacaguccagaggcgaggcuaaggugccuaacaauu .<<<<<...<<....>>...>>>>>.......................<<<<<<.<<<......>>>.>>>>>>....<<<......>>>............................ .((((....(......)....)))).......................((((((.(((......))).))))))....(((......)))............................ Large subunit of the Chlamydomonas reinhardtii mitoribosome; L4 rRNA 7pkt 5 149 3.0 RF02541 URS00023359BA_3055 34887394 0003735 0005840 3055 aagguagagucugcguugaacaccagaacauaggcuuggaagcagccacugugcuuggaaagcguaauagcucacuggucuagcagucuccgcuuauauauguccggcacuauugccgaagcccgccuaugacaaauuuuuuuuuuuuu <<..<.<<<.<<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>>.>>>.>.>>...................................................... ((....(((..(.(.......(((.(..((..(((.........)))..))......(...((......)).).).)))...).)..)))...))...................................................... Large subunit of the Chlamydomonas reinhardtii mitoribosome; L5 rRNA 7pkt 6 136 3.0 URS00023359B4_3055 34887394 3055 agucauagguagcagaacguucuggaacaauuacgcugaaaacaguaacagaauugaagcugcuaacauaaguaacacuaaauggauaacauggccguaagcccaagguuuugcauaacaaacagugaauacgguu ...................<<<<<............<<....>>....>>>>>............................<<<.....>>>...................<<.........>>............ .................(.(((((............((....))....)))))..).........................(((.....)))...................((.........))............ Large subunit of the Chlamydomonas reinhardtii mitoribosome; L6 rRNA 7pkt 7 578 3.0 RF02541,RF02540 URS00023359B8_3055 34887394 0003735 0005840 3055 uaccguacugcaaaccgacucaggugggcuaguauauauacucaggccauagaaucaaccauguuaaaggaacucggcaaaaugcacgcgugaccucggaggaagcguggcuaaaaagacucagcaaauagccgacagcgacuguuuaccaaaaacacaggauagugcuaacagacguaaauuaagcugcaaaaagcgguuuuauuuuuggauguauacuauccgacgccaaacggcggcaguaacucuaacuguccuaagguagcgaaauuccuugacuuguaauuggcguccugcaugaauggcggaacgacugucgggcugucucuaacauggaaucugugaauuugaaaucuucgugcagaugcgaaggcgcuggcaagggacgaagagacccuaugcagcuucgcugggugcuaagaguuacucuuauccucaagcuuuucugggacggaugcuuccuaaauaguaacgggagugaucaaugguacugcuacuuaaauagaaagcagugcuugacuguaagaaccacaguucgagcagggacgcaagucggcauuaaugacccaggguaacau ..............<<......>>......<<<......>>>........<<<.<...<<<<<<<<.<<...............<<<<<...............>>>>>.<<....>>.............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<......<<<.<<<<<<<.....>>>>>>>.>>>..>>.......>>>>>>>..<<<........<<<.<..........>>>>....................<<<...........>>>...........>>.>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>.............<<<<<........>>>>>....................................<<<..<.<.<<<<<<<.>>>>>>>..>.>.>>>...<<<.....>>>.<<<<<<...........>>>>>>...<...<<<<<<<<..<<..(((>>...>>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>.))).................. ..............((......))......(((......)))........(((.(...((((((((.((..(....(.........(.(....(.[..).....).)...((....)).(...).......(((((((((...((.........))...(((((((.....(.......(((.((((.((.....)).)))).)))...).......))))))).].(.........(.(.............).).........(..........(.(...........).)..).........)....)).))))))).)..))).)))))))).))))..........[..(((((......].)))))....................................(((..(.(.(((((((.)))))))..).).)))...((......[))..(((((..........])))))....(...((((((((...(..[[[)....))))))))...((((..(((......)))..))))..((....))..).]]].................. Large subunit of the Chlamydomonas reinhardtii mitoribosome; L7 rRNA 7pkt 8 413 3.0 RF02541,RF02540 URS00023359B7_3055 34887394 0003735 0005840 3055 guuacccugaucaacggacaaaagcuacgcuagggauaacaggcuuauccgccuuuagaguuccuaucgaugggcggguuuggcaccucgaugucggaucaucgcguccuguggcugaaggaggucgcaaggguuggauuguucguccauuaaagugguacgugaucugaguucagaccgucgugagacaguucgguuucuaucuuugucagcgaaaggcuuguuuugaaacgccuaugcacaguuagccgcugggggcgaguacgaaaggaccagaccccuauaaaccucugguacacuuguugucauuuacacggcauagcaagaaagcuaaguuuuaaaaggcuagauugccuacauucaauaacaccgaaugaccccgacuuacaaaaaguuuaggacuaaauuuauga .........................................<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.........<<<.<<<<<...<<<<<<<<<......>>>>>>>..>>.<<.<<.....>>.>>......>>>>..>...>>>.......<<.<<<<....>>>.>.>>......................<<<...<<<....>>>.>>>..<<<....<<<<<...<<<<<...................>>>>>..<<<<...<<<<...<<<<<<<<<........>>>>..>>>>>...>>>>.>>>>.....>>>>>...>>>.....<<<.........>>>....<<.<<<<<.....>>>>>..>>............. ........................................(((((.(.((((((...((.......))...))))))...)))).).)........((.((((.(..((((((.((......)).)))..)))..(..(.....)..)......).)))..)...))........((.((((....))).).))......................(.(.....(((.)))...))..(((......(((...(((((......(....).......)))))..((((...((((...(((((((((........))))..)))))...)))).)))).....))).....)))......((.........)).....((.(((((.....)))))..))............. Large subunit of the Chlamydomonas reinhardtii mitoribosome; L8 rRNA 7po2 A 955 3.09 RF00177 URS0001A24B4C_9606 35676484 0003735 0005840 9606 aauagguuugguccuagccuuucuauuagcucuuaguaagauuacacaugcaagcauccccguuccagugaguucacccucuaaaucaccacgaucaaaagggacaagcaucaagcacgcagcaaugcagcucaaaacgcuuagccuagccacacccccacgggaaacagcagugauuaaccuuuagcaauaaacgaaaguuuaacuaagcuauacuaaccccaggguuggucaauuucgugccagccaccgcggucacacgauuaacccaagucaauagaagccggcguaaagaguguuuuagaucacccccuccccaauaaagcuaaaacucaccugaguuguaaaaaacuccaguugacacaaaauagacuacgaaaguggcuuuaacauaucugaacacacaauagcuaagacccaaacuggganuagauaccccacuaugcuuagcccuaaaccucaacaguuaaaucaacaaaacugcucgccagaacacuacgagccacagcuuaaaacucaaaggaccuggcggugcuucauaucccucuagaggagccuguucuguaaucgauaaaccccgaucaaccucaccaccucuugcucagccuauauaccgccaucuucagcaaacccugaugaaggcuacaaaguaagcgcaaguacccacguaaagacguuaggucaagguguagcccaugagguggcaagaaaugggcuacauuuucuaccccagaaaacuacgauagcccuuaugaaacuuaagggucgaagguggauuuagcaguaaacugagaguagagugcuuaguugaacagggcccugaagcgcguacacaccgncngucacccuccucaaguauacuucaaaggacauuuaacuaaaaccccuacgcauuuauauagaggagacaagucguaacaugguaaguguacuggnnagugcacuuggacgaacc ...((((..<<<<<<.)))).<<<<<<.<<..<<<<<<<<....<<<.<<<..<......>......<<.......<<<<.<..<<<.....>>>.>..>>>>..<<<<....<<...<<<....>>>..>>......>>>>.<<...>>.>>.<<<....>>>.....>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>.....<<<<<<<<.....(((.....((.>>>)).......)))..>>>>>..>>.>>>>>>....<<<((.....<<<<..<<<<...............<<<<<<......<<<.<<<.<<<......>>>..>>>.>>>.............<<....>>.>>>>>>.....>>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<.<<<<<......))..>>>>>.>.>>>.<<.......<<<<....>>>>.....>>..>>>>>><<<<<.<<<<<<<...<<<.<<<<<..<<<<<<<<<<.....<<........>>..........<<<<<<<.......<<.<<<..<<<<<<.......<<..<<<<<.....>>>.......>>..>>.....<<<....>>>.........>>>...>>>>>>>>....>>>>>>>..>>.>>>>>>>>.....<<<<.....>>>>.....<....<<<<<<<.......>>>>>>>....>.....>>>>>.....<<<<<<<.........>>>>>>>.....>>>...>>>>>>>>>>.>>....<..<<.<...<<<<<<..<<<<<......<<<....<<.....>>...>>>.......>>>>>.>>>>>>....>.>>...>.....<<<<<<<<<....>>>>>>>>>......... .[.[[[[..(((((..]]]]]((((((.((..((((((((..(.(((.(((..(......)......(((......((((.(..(((.....))).)..))))..((((....((..((((....))).)))......)))).((...))))).(((....))).....)))))))......(.(((...(((((....)))).))))).)).)))))).....((((([[[.....(((.....((.]]])).......)))..)))))..)).))))))....((([[...(.((((...(((...............(((((((.....(((.(((.((........))..))).))).....).....(.((....))))))))).....)))....))))....((((((...((...((((.........))))...))))))))......{...(.(((((......]]..))))).))))).((.......((((....)))).....))...)))))(((((.(((((((...(((.(((((..((((((((((.....((........))..........(((((((.......((.(((...((((((.(....((..(((((.....))).......))..)).....(((....))).....).).)))...)).)))))....)))))))..)).)))))))).(...((((.....)))).....(....(((((((.......)))))))....)..)..))))).....(((((((.........))))))).....)))...)))))))))).))..(.(..((.(...((((((..(((((..((..(((....((.....))...)))..).)..))))).))))))....).))...)..)..(((((((((....)))))))))}........ Initiation complex of human mitochondrial ribosome small subunit with IF2, fMet-tRNAMet and mRNA; 12S mitochondrial rRNA 7po2 5 71 3.09 URS0000D77905_9606 35676484 9606 aguaaggucagcuaaauaagcuaucgggccnauaccccgaaaauguugguuauacccuucccguacuacca <<<<.<<..<<<<.....>>>>.<<<<<.......>>>>>.......<<......>>...>>.>>>>.... ((((.((..((((.....)))).(((((.......))))).......((......))...)).)))).... Initiation complex of human mitochondrial ribosome small subunit with IF2, fMet-tRNAMet and mRNA; fMet-tRNAMet 7po2 6 31 3.09 35676484 9606 cugauguucgccgaccguugacuauucucua ............................... ............................... Initiation complex of human mitochondrial ribosome small subunit with IF2, fMet-tRNAMet and mRNA; mRNA 7pwg 1 2450 2.75 RF02543,RF02540 URS00023358CC_184922 35100413 0003735 0005840 184922 cggcccgaggcggcgggggcgacgggcggaacuuaagcauaucagnacgccccggaggagaaaccaaccgggauuccccguagcggcgagcgacgcgggaggagcccgccccgaaggcgcgcugugggcgccgcgagggggcccgagggccccgcccgagagggugcaagccccguacggcgggcgaguagcgcugcuugagcgugcagcgcgaagggaggcgcggcccuuccaaggcuaaauacgccccgggaccgauagcggaccaaguagcgcgancgaacggugaaaaggacgcccggccgcucaaaagaccugaacccggccggcgccggcccgccggccccnucucganacncggaccgaggagccacgcgccgcggcgagcccgagggccccgcggcggagcgagcgcgagacgccccgggcccgccgcgccccugcgggcgugcgcgggccgagccgcggcgcgugggcccganaggcggugaucuaugcccggcgagggcgaggccgggcgaaagccugguggaggcccgccgcggugcugacgcgcagaucgcucgucggagccgggcauggnggcgaaagacucaucgaaccgccugguagcugguugccuccgaaaugucucccaggacagccgccgcccgcaguugcggcccguagagcgcuggccggcggccgccccccaaacuccgaagggccgcgccgccccgcccuggccugggcggggcgggcgaaugcgggcggcgcgugggccccuccugguaagcaggacgggcgaggcgggacgauccggacgccgggccagggugcgccgccggggccggaacggcgucggccgcggccggcccggaaaauggagcgcgccggagccccggacccgcgcccggccgccgcgcgcggcggguaggaggccgcagaggccccgggggcgaaggcggcgcgcaggccccgccggaccggccucuggugcanaucucggcagcaguagcgcuacuccgcgccccggaggacugagggggagacggguuccgcggcgccugcaucuggccgcggnugacucgggccuaagcggcgggugaagaccgggaaggggcgugcccgcccgucgaacggggagccggcggagacuccggcaggcgcgggcggagacgcgccccccggcgacgcgcacggggaccgcggcgggcggcgccccggcccgcgaacgccccgcagcccccggacgccuugcgcggagaggggggcccgggggcggaccgcgcguccccggccgccccugaaaagccggggggcccgcgcgccguaccgaccgcacaggacuccggggucagcagccucuagcgcgggagcgaacncggcucagggaagucggcaagccggcuccguaaccucgggaaaaggaguggcucugacggggucagaacuggaacggacgcggggaucccgacuguuuacuagaaacacagcgucgcgagggccgcacccggcgcuggcgcgacgugauuucugccnagugccagaccgucaccgugaagcgauccgccgaagcccugguaaacggcgggaguaaugacucucuuaagguagcnaanugccucnucgggcaauuuccgacggcaugaauggaccaacgaggaucccacugunccgagccgcgccuccgcgagccuccagccucgggaacgggcgagggccggccagcggngcaagaagacccunnugagcuugacnccagcccgggccuguggggcggggccgccccgcucacccggucgcgcggggacccgcccgggcggggaguucggcugnggcggcgcgccugcuacaccggaccgcaggcnucccacggcgggcucagcgaggacccucccgcggagcagaagggcacaagcccgcccgacccgcgccccccgugccggcgcgggccgcgaaagcggggccuaccgauccuucgccgccccggccgcgggcgcggagguggcagaaaaguuaccacagngauaacuggcuuguggccgccgagcgcccgcagcgacgcggcuuuuugauccuungaugucggcucuuccuaccguccgcgcgcaccggcgcggaagcgucggauuguucacccguucaagggaucgugagcuggguuuagancgucgugagacgguuaguuuuacccuacuggccccggggccagagcacggcgggccaguacggaggaacgcccgccgcgggcgcccagccccgcgguugcccgccggggcaggaccgcgcgcccgggcccgggggccuggcgcugccgccucuaaagcgccaccccccccuccggccccgccgcccgcgccccagccccgugcccccugcccgaggcggcccccgcccgggaggaccacccggcgcggcgccccuguacggcgagggcgcguucgcccggggggcgcgccgcgggcgcg ......................<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<....<<.....>>.....>>>>>..[[[...<<<<...........>>>><<<<.....<<<<<......>>>>>((......<<<.....))>>>....>>>>........<<<<<<<........>>>>>>>...(((((..<<<<<<)))))..]]]..................................<<....>>................<<<.>>>...........................<<<<<<..>>>>>>.<<<<........>>>>.<<<<<....<<<<<<<<<<<<<..<<<...<<<.>>>..>>>...<<....>>............<<<<<<<<<<<<<....>>>>>>>.>>>>>>...>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<<<<<.<<<<<<<<<...<<<...<<<..<<<<..>>>>..>>>..>>.>...>>>>>>>.<<<<<<<<<<<......>>>>>>>>>>>...>>>>>>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((...<<<<<<<.....<<<.<<<<<<<..>>>>>>>>>>..........)))......>>>>>>>>>>>..>>>>>>><<<<<....>>>>>....>>>>>><<<<<<<<<<...<<......<<<<<.<<....>>.>>>>>...>>>>>>>>>>.>>.....>>>>>.<<.....<<....<<<<<.....>>>>>..<<.....<<<<..<<...<<<<<<...<.......>.>>>>>>....((<<<.<<...<<<...<<<....>>>......<<<<..>>>>...>>.>....>>...<<<<<........>>>>>))<<<<<<<<<....>>><<<<<<<<<<...<<<..<<<<<<<<<<<<<<<<<.........>>>>>....<<<<<<...<<<<<<....<<.....>>......>>>>>>...>>>>>>..>>>>>.>>>>>>>..>>>.........>>>>>>>>>>>>>>>>.>>>..>>..<<.....>>.>>>>.<<<<.....>>>>..>>....<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<...>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<....>>>>......>>>>>>>...<<..<<<..<<<<<<<...<<....<<<.<....>.>>>....>>.>>>>>..>>>>><<<<<<....>>>>>>........<...........<<<<<<.....>>>>>>....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>....>>....<<<<<........>>>>>...((((((..{{{.........{{{..{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<..>>>>>>>>>...<<<<......>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<.<<<<..>>>>.>.....<<...(((>>....>>>>>>>...<<<<<<<<.........>>>>>>>>.<<<....>>>.>>))).......(((((.(((((.>>>>>>))))))))))..........]]]]..}}.}}}.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<.........>>>....>>>>>..>...>>>.>>....<<<<<<<....>>>>>>>........}}}.))))))..<<<<<<.<<<..<<<<<<<<..............>>>>>>>><<<<<...<.<....<<<<<<<<<<....>>>>>..>>>>>....>.>.>>>>>.<<<...<<<<<<...........>>>>>>...>>>..>>>.>>>>>>...<.<<<.............................>>>.>...<<.<<<<.......>>>>..<<<<<<<<<<<....<<<<<<.<..>.>>>>>>...>>>>.>>>>>>>....>>. ......................((((((.....(...[..)......))))).).........((....))...((((....((.]...)).....))))...((((..(((..((...)....))))((((.....(((((......)))))[[(...).(((.....]])))....))))...)....(((((((........)))))))...(((((..[[[[[[)))))..)))..................................((....))............(...(((.)))...........)...............((((((..))))))[((((........)))).(((((..(.(((((((((((((..((....(((.)))...))...((....))....(......)(((((((...(((....)))...).))))))...)))))))))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))).((((((....(((((....)))))(((((((((((((.(((((((((...(((...((...((((()))))...))..)).)...))))))).((.((((((((......)))))))).))...))))))))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(((((((.....(((.(((((((()))))))))))..........]]]......))))))))))...)))))))(((((....)))))....))))))(.((((((((...((......(((((.((....)).)))))...))))))))))..).....))))).((.....((....(((((.....)))))..((.....((.(..((...((((((...(.......).))))))....[[(((.((...(((...(((....))).(....((((..)))).).)).)....))...(((((........)))))]](((((((((....)))((((((((((...(((..(((((((((((((((((...{.{...)))))....((((((...((((((....((.....))......))))))...))))))..))))).)))))))..)))(...)....)))))))))))))))).)))..))..((.....)).).)).((((.....))))..))....((((....((((((((.((..(....(.......(((((....(.{..).....)))))((.((((((...)))))).))(...).......(((((((((.].((.........))...(((((((....((((....))))......))))))).}.(((.(((..(((((((...((....(((.(....).)))....)).)))))..)))))(((((......)))))........((..........(((((.......))))).)..)....)))....)).))))))).)..))).)))))))).))))))....))....(((((.....]..)))))...((((((..(((.((......(((..((((((..(((((.((((((((..(((((((((..)))))))))...((((......)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.(.((((..)))).)...).((][.[[[))....))))))).(.((((((((.....{...)))))))))(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....)}....))))..)).))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(((((((((......))))))..))).(((.(.....).)))....)))))..)...))).).....(((((((....)))))))..>.))..))).))))))..(((((..(((..((((((((.....(...)....))))))))(((((...(.(....((((.(((((}.}.)))))...))))....).).))))).(((....((((.............))))....)))..)))..)))))(..(.(((.............................))).)..)((.((((.......))))..(((((((((((....(((((..(())..)))))...)))).)))))))....)). Cryo-EM structure of large subunit of Giardia lamblia ribosome at 2.7 A resolution; rRNA 28S 7pwg 3 117 2.75 RF00001 URS000044BDD8_184922 35100413 0003735 0005840 184922 aguucggccauccuacggcggaaacuccuuaacucguuccgaauuaagaagagaagcgccgucaggccccgccaguacugcgaucggagacgucgugggaacacggggugccgaacc .<<<<<<<....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>><<<<<<......<<<<<<.<<....>>>>>>>>.....>>>>>>>>>>>>>. .(((((((....((((((((.....((((((...(.....)...))))..))....)))))).))((((((......(((((..((....)).))))).....))))))))))))). Cryo-EM structure of large subunit of Giardia lamblia ribosome at 2.7 A resolution; rRNA 5S 7pwg 4 138 2.75 URS00023358B4_184922 35100413 184922 gaacgccccgccggcggaugccucggcccgggcggcgacgaagagcgcggcggagcgcgagacgcggugcggacccgcccgccccgagaagcaccgacccucgaacgcagcgcgcccggcgccgccgccucngcgccc ..........................................<<<<<<.((.....>>>.....<<<<<<...<..))..>.........>>>>>>...>>>....<<...>><<...>>.................. ..........................................((((((.[[.....))).....((((((...(..]]..).........))))))...)))....((...))((...)).................. Cryo-EM structure of large subunit of Giardia lamblia ribosome at 2.7 A resolution; rRNA 5.8S 7pwg w 14 2.75 RF00005 URS00023358BC_184922 35100413 0030533 0006412 184922 agcggccgccacca .<<<..>>>..... .(((())))..... Cryo-EM structure of large subunit of Giardia lamblia ribosome at 2.7 A resolution; E-site tRNA 7pwo 1 2448 2.75 RF02543,RF02540 URS00023358B7_184922 35100413 0003735 0005840 184922 cggcccgaggcggcgggggcgacgggcggaacuuaagcauaucagnacgccccggaggagaaaccaaccgggauuccccguagcggcgagcgacgcgggaggagcccgccccgaaggcgcgcugugggcgccgcgagggggcccgagggccccgcccgagagggugcaagccccguacggcgggcgaguagcgcugcuugagcgugcagcgcgaagggaggcgcggcccuuccaaggcuaaauacgccccgggaccgauagcggaccaaguagcgcgancgaacggugaaaaggacgcccggccgcucaaaagaccugaacccggccggcgccggcccgccggccccnucucganacncggaccgaggagccacgcgccgcggcgagcccgagggccccgcggcggagcgagcgcgagacgccccgggcccgccgcgccccugcgggcgugcgcgggccgagccgcggcgcgugggcccganaggcggugaucuaugcccggcgagggcgaggccgggcgaaagccugguggaggcccgccgcggugcugacgcgcagaucgcucgucggagccgggcauggnggcgaaagacucaucgaaccgccugguagcugguugccuccgaaaugucucccaggacagccgccgcccgcaguugcggcccguagagcgcuggccggcggccgccccccaaacuccgaagggccgcgccgccccgcccuggccugggcggggcgggcgaaugcgggcggcgcgugggccccuccugguaagcaggacgggcgaggcgggacgauccggacgccgggccagggugcgccgccggggccggaacggcgucggccgcggccggcccggaaaauggagcgcgccggagccccggacccgcgcccggccgccgcgcgcggcggguaggaggccgcagaggccccgggggcgaaggcggcgcgcaggccccgccggaccggccucuggugcanaucucggcagcaguagcgcuacuccgcccccggaggacugagggggagacggguuccgcggcgccugcaucuggccgcggnugacucgggccuaagcggcgggugaagaccgggaaggggcgugcccgcccgucgaacggggagccggcggagacuccggcaggcgcgggcggagacgcgccccccggcgacgcgcacggggaccgcggcgggcggcgccccggcccgcgaacgccccgcagcccccggacgccuugcgcggagaggggggcccgggggcggaccgcgcguccccggccgccccugaaaagccggggggcccgcgcgccguaccgaccgcacaggacuccggggucagcagccucuagcgcgggagcgaacncggcucagggaagucggcaagccggcuccguaaccucgggaaaaggaguggcucugacggggucagaacuggaacggacgcggggaucccgacuguuuacuagaaacacagcgucgcgagggccgcacccggcgcuggcgcgacgugauuucugccnagugccagaccgucaccgugaagcgauccgccgaagcccugguaaacggcgggaguaaugacucucuuaagguagcnaanugccucnucgggcaauuuccgacggcaugaauggaccaacgaggaucccacugunccgagccgcgccuccgcgagccuccagccucgggaacgggcgagggccggccagcggngcaagaagacccunnugagcuugacnccagcccgggccuguggggcggggccgccccgcucacccggucgcgcggggacccgcccgggcggggaguucggcugnggcggcgcgccugcuacaccggaccgcaggcnucccacggcgggcucagcgaggacccucccgcggagcagaagggcacaagcccgcccgacccgcgccccccgugccggcgcgggccgcgaaagcggggccuaccgauccuucgccgccccggccgcgggcgcggagguggcagaaaaguuaccacagngauaacuggcuuguggccgccgagcgcccgcagcgacgcggcuuuuugauccuungaugucggcucuuccuaccguccgcgcgcaccggcgcggaagcgucggauuguucacccguucaagggaucgugagcuggguuuagancgucgugagacgguuaguuuuacccuacuggccccggggccagagcacggcgggccaguacggaggaacgcccgccgcgggcgcccagccccgcgguugcccgccggggcagaccgcgcgcccgggcccgggggccuggcgcugccgccucuaaagcgccaccccccccuccggccccgccgcccgcgccccagccccgugcccccugcccgaggcggcccccgcccgggaggaccacccggcgcggcgccccuguacggcgagggcgcguucgcccggggggcgcgccgcaggcgcg ......................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<....<<.....>>.....>>>>>..[[[...<<<<...........>>>><<<<..<..<<<<<......>>>>>((......<<<.....))>>>...>>>>>........<<<<<<<........>>>>>>>...(((((..<<<<<<)))))..]]]..................................<<....>>................<<<.>>>...........................<<<<<<..>>>>>>.<<<<........>>>>.<<<<<....<<<<<<<<<<<<<..<<<...<<<.>>>..>>>...<<....>>............<<<<<<<<<<<<<....>>>>>>>.>>>>>>...>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<<<<<.<<<<<<<<<...<<<...<<<..<<<<..>>>>..>>>..>>.>...>>>>>>>.<<<<<<<<<<<......>>>>>>>>>>>...>>>>>>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((...<<<<<<<.....<<<.<<<<<<<..>>>>>>>>>>..........)))......>>>>>>>>>>>..>>>>>>><<<<<<..>>>>>>....>>>>>><.<<<<<<<<...<<......<<<<<.<<....>>.>>>>>...>>>>>>>>>>..>.....>>>>>.<<.....<<....<<<<<....>>>>>..<<.....<<<<..<<...<<<<<<...<.......>.>>>>>>....((<<<.<<...<<<...<<<....>>>......<<<<..>>>>...>>.>....>>...<<<<<........>>>>>))<<<<<<<<<....>>><<<<<<<<<<...<<<..<<<<<<<<<<<<<<<<<.........>>>>>....<<<<<<...<<<<<<....<<.....>>......>>>>>>...>>>>>>..>>>>>.>>>>>>>..>>>.........>>>>>>>>>>>>>>>>.>>>..>>..<<.....>>.>>>>.<<<<.....>>>>..>>....<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<...>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<....>>>>......>>>>>>>...<<..<<<..<<<<<<<...<<....<<<.<....>.>>>....>>.>>>>>..>>>>><<<<<<....>>>>>>........<...........<<<<<<.....>>>>>>....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>....>>....<<<<<........>>>>>...((((((..{{{.........{{{..{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<..>>>>>>>>>...<<<<......>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<.<<<<..>>>>.>.....<<...(((>>....>>>>>>>...<<<<<<<<.........>>>>>>>>.<<<....>>>.>>))).......((((((.((((.>>>>>>))))))))))..........]]]]..}}.}}}.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<.........>>>....>>>>>..>...>>>.>>....<<<<<<<....>>>>>>>........}}}.))))))..<<<<<<.<<<..<<<<<<<<..............>>>>>>>><<<<<...<.<....<<<<<<<<<<....>>>>>.>>>>>....>.>.>>>>>.<<<...<<<<<<...........>>>>>>...>>>..>>>.>>>>>>...<.<<<.............................>>>.>...<<.<<<<.......>>>>..<<<<<<<<<<<....<<<<<<.<..>.>>>>>>...>>>>.>>>>>>>....>>. ......................((((((.....(...[..)......))))).).........((....))...((((....((.]...)).....))))...((((..(((..((...)....))))((((.....(((((......)))))[[(...).(((.....]])))....))))...)....(((((((........)))))))...(((((..[[[[[[)))))..)))..................................((....))............(...(((.)))...........)...............((((((..))))))[((((........)))).(((((....(((((((((((((..((....(((.)))...))...((....))....(......)(((((((.(.(((....))).).).))))))...)))))))))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(((((....)))))(((((((((((((.(((((((((...(((...((...((((()))))...))..)).)...))))))).((.((((((((......)))))))).))...))))))))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(((((((.....(((.(((((((()))))))))))..........]]]......))))))))))...)))))))(((((....)))))....))))))(.((((((((...((......(((((.((....)).)))))...))))))))))..).....))))).((.....((....(((((....)))))..((.....((.(..((...((((((...(.......).))))))....[[(((.((...(((...(((....))).(....((((..)))).).)).)....))...(((((........)))))]](((((((((....)))((((((((((...(((..(((((((((((((((((...{.{...)))))....((((((...((((((....((.....))......))))))...))))))..))))).)))))))..)))(...)....)))))))))))))))).)))..))..((.....)).).)).((((.....))))..))....((((....((((((((.((..(....(.......(((((....(.{..).....)))))((.((((((...)))))).))(...).......(((((((((.].((.........))...(((((((....((((....))))......))))))).}.(((.(((..(((((((...((....(((.(....).)))....)).)))))..)))))(((((......)))))........((..........(((((.......))))).)..)....)))....)).))))))).)..))).)))))))).))))))....))....(((((.....]..)))))...((((((..(((.((......(((..(.((((..(((((.((((((((..(((((((((..)))))))))...((((......)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.(.((((..)))).)...).((][.[[[))....))))))).(.((((((((.....{...)))))))))(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....)}....))))...).))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(((((((((......))))))..))).(((.(.....).)))....)))))..)...))).).....(((((((....)))))))..>.))..))).))))))..(((((..(((..((((((((.....(...)....))))))))(((((...(.(....((((((((((}.}.))))).)))))....).).))))).(((....((((.............))))....)))..)))..)))))(..(.(((.............................))).)..)((.((((.......))))..(((((((((((....(((((..(())..)))))...)))).)))))))....)). Cryo-EM structure of Giardia lamblia ribosome at 2.75 A resolution; rRNA 28S 7pwo 3 117 2.75 RF00001 URS000044BDD8_184922 35100413 0003735 0005840 184922 aguucggccauccuacggcggaaacuccuuaacucguuccgaauuaagaagagaagcgccgucaggccccgccaguacugcgaucggagacgucgugggaacacggggugccgaacc .<<<<<<<....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>><<<<<<......<<<<<<.<<....>>>>>>>>.....>>>>>>>>>>>>>. .(((((((....((((((((.....((.(((...(.....)...)))...))....)))))).))((((((......(((((..((....)).))))).....))))))))))))). Cryo-EM structure of Giardia lamblia ribosome at 2.75 A resolution; rRNA 5S 7pwo 42 138 2.75 URS00023358B4_184922 35100413 184922 gaacgccccgccggcggaugccucggcccgggcggcgacgaagagcgcggcggagcgcgagacgcggugcggacccgcccgccccgagaagcaccgacccucgaacgcagcgcgcccggcgccgccgccucngcgccc ..........................................<<<<<<.((.....>>>.....<<<<<<...<..))..>.........>>>>>>...>>>....<<...>><<...>>.................. ..........................................((((((.[[.....))).....((((((...(..]]..).........))))))...)))....((...))((...)).................. Cryo-EM structure of Giardia lamblia ribosome at 2.75 A resolution; rRNA 5.8S 7pwo w2 14 2.75 RF00005 URS00023358D1_184922 35100413 0030533 184922 agcggccgccacca .<<<..>>>..... .(((())))..... Cryo-EM structure of Giardia lamblia ribosome at 2.75 A resolution; E-site tRNA 7pwo 2 1355 2.75 RF01960,RF01959,RF00177 URS00023358C0_184922 35100413 0003735 0005840 184922 auccggucgauccugccggagcgcgacgcucuccccaaggacgaagccaugcaugccucaggacgcggcggacggcucnggacaacgguugcaccncccguggcggucgccggacaccgcuggcaacccggcgccaagacgugcgcgcaagggcgggccccgggcgagcagcgugacgcagcgacggcccgcccgggcuuccggggcaucacccggucggcgcggucgcggcgcgccgagggcccgacgccuggcggagaaucaggguucgacuccggagagcgggccugcgagacggcccgcacauccaaggacggcagcaggcgcggnacuugcccaaugcgcggcgcgcngcggcgcgacggggugcgcgcgagucaggcgggcccaccccgacccgccagggcaaggcuggugccagcagccgcgguaauuccagcucggcgagcgucgcgcggcgcugcugcaguugaaacgcccguaguuggccccccgccgccacgaggaaacgggagcgcuccaggcagguuggacccgccgcgugggaccgcggcgggcccggcgcgccgcggcagccccgaggagagcgggcgggggcaccgguaccggccggggacgggugaaacaggaugaucccgccgagaccgccggccgcgcaggcgccugccaagaccgccucugucaaucaagggcgaaggccgggggcuagaaggcgaucagacaccaccguauucccggccguaaacggugccgccccgcggccggcgcgcgucccgccggccgcccagggaaaccgggaggcuccgggcucuggggggaguauggccgcaangcugaaacuugaaggcauugacggagggguacaccagacguggagucugcggcucaaucugacncaacgcgcgcaccucaccaggcccgcgcggugnugcauggccgcucccagcccgugncgcgagccgugcuccauugcgacaacgagcgagaccccggccgcgggccgcgggacggcccgcagcgggaggacggcggggcgauagcaggucugugaugcccuccgcccugggccgcacgcgcgcuacacuggcggggccagccggcgcccgcgaggacgcgagcccccgccguggccgggaccgcgggcuggaacgcccccgcgcaccagnaaugucuuguaggcgcccgcccccaccgcgcgccggacgcgucccugccccunguacacaccgnccgucgcuccuaccgacugggcgcugcggcgagcgccccggacgggaagggccgcgagccccngcgccuggaggaaggagaagucguaacaagguaucnguaggugnnccugcggauggaucccu ..<<<<<.[..(((>>>>>.<<<<<<<<<..<<<....<......<<<.<<<..<<<.........>>>......<<........<<<..<<..<<...<<<<<......<<.....<<<<<<....>>>>>>......>>.....<<....<<<.......<.....>..>>>...>>.......>.>>>>..>>>>..>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>...<<<<<<<<....>>>>...>>>>.>>.<<<<<<..........>>>>>>.<.<<....>>.>...>>>>>>.........<<<....<<<...>>>..>>>..>.....>>>..........<<<.<<.........>>.>>>..<<<.<(((...<<<<<.....<<.)))>>.......>>>>>>.>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.......<<<.<<<<<<.......<<..<<.......>>........>>.....>>>>>..>.>>><<<<<<.......>>>.>.>>..........<<<<<<<.....<<<<..<<..<<<<<.<<<..<.<......>.>.....>>>.>>>>.>.>>.......<<....>>...>>>>....>>>>.>>>...>>>...>>>>...<<<<<<<<...<...<<.<.<.....>.>.>>...>>>>>>>>>.........<<<.<<..<<<<<<<<<<.<...>.>>>>>>>>>>...<<..))>>....>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..)))..]<<<<<.<<<<<<<.<<.<<<<<<..<<<.<<<<<<......<<........>>.........<<<<<.<.....<<.<<<..<<.<<<<<<....<<.<<<<<<....>>>..<<......>>....>>>.>>....<<<<<.<<<<<<.>>>>>>.....<<<<<.>>>>>.......>>>>>....>>>.>>>.....>>>>>>>..>.>>>>>...>>.>>>>.>>>.....<<<<<<<.......<<<.<<....>>.>>>....>>>>>>>......<....<<.<<<<......>>>>.>>....>.....>>>>>>....<<<<<.<<.......>>.>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<<.<<....<<<<<<<<.<<<..<<<.<<<.........>>>.>>>..>>>.>>>>>>>>...>>.>>>>>..>.>>...>.....<<<<<<<<<<..>>>>>>>>>>........ ..((((..[..[[..)))).(((((((((...((....((.....(((.(((..(((.(.....).)))......(((.......(((..((..((...(.((.......(......(((.((....)).))).......).....((....(((.......(.....)..)))...)).........)).)..))))..))).(((....(((..((((((((.......)))))))))))......)))...(((.(((......)))....)))))).((.(((..........))).)).(.((....)).)...)))))).).......(((....((((.))))..)))..).....))...........(((.((.........)).)))..(((..[[....(((((.....((..]])).......)))))..)))..)))))))))...[......((([[...(.((((...(((.......(((.((((((.(.....((..((.......))........))..)..)))))..).))).((.((.......))..).)..........((((((((.(...((((..((...((((.((...(..........)......)).))))...)).......((....))...))))..).)))).)))..))))...))))....((((((....(...((.(.........).))...).))))))......{...(((.((..((((((((((.(...).))))))))))...((..]]))....))...].))))))).(((......(((......)))....)))...]]..](((((.(((((((.((..(((((..(((.((((((......((........)).........(((((.(.....((.(((...(.((.(((....((.((((((....)))..((......))....))).))....(((((.((((((.))))))..(..(((((.))))).....).)))))....)))..)).....).)))))..).)))))...)).)))).))).(...(((((((.......(((.((....)).)))....)))))))......(....((.((((......)))).))....)..)..))))).....(((((.((.......)).)))))......))...)))))))))).))..(.(..((.(.(((((.((..(.((((((((.(((..(((.(((...(.)...))).)))..))).)))))))))..)).)))))..).))...)..)..(((((((((....)))))))))}....... Cryo-EM structure of Giardia lamblia ribosome at 2.75 A resolution; rRNA 18S 7pzy 1 3209 2.32 RF02540,RF02543 URS0000C2FD9C_237561 35613268 0003735 0005840 237561 ugaccucaaaucagguaggacuacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaacagggauugccucaguagcggcgagugaagcggcaaaagcucaaauuugaaaucuggcgucuuuggcguccgaguuguaauuugaagaagguaucuuugggcccggcucuugucuauguuccuuggaacaggacgucacagagggugagaaucccgugcgaugagaugacccgggucuguguaaaguuccuucgacgagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcuugagaucagacuugguauuuugcaugcugcgguuuaccgggccagcaucgguuuggagcggcaggauaauggcggaggaauguggcacggcuucugcuguguguuauagccucugacgauacugccagccuagaccgaggacugcgguuuuuaccuaggauguuggcauaaugaucuuaagucgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccguacgcguaaugaaagugaacgaaggugggggcccauuagggugcaccaucgaccgauccugauguguucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagaagucuugggguugaaaugaccuuaacuuauucucaaacuuuaaauauguaagaaguccuuguugcuuaauugaacguggacaauugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacgugaaguuaaagugccggaaugcacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcgugcuacuuauacuucaccgugauugcuguuuugacgcuuucacgaguaggcaggcguggaggucagugacgaagccuuugcuguaaagcugggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccaugucaacagcaguuggacauggguuagucgauccuaagagauggggaagcuccguuucaacgugcuugauuuuucaggccaaccaucgaaagggaauccgguuaaaauuccggaacuuggauauggauucuucacggcaacguaacugaauguggagacgucggcgugagcccugggaggaguuaucuuuucuucuuaacagcuuaucacccuggaauugguuuauccggagauggggucuuauggcuggaagagcgcgguaauuuugccgcguccggugcgcuuacgacgguccuugaaaauccacaggaaggaauaguuuucaugccaagucguacucauaaccgcagcaggucuccaagguuaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaaggaucgggugucuugggccuuguguagacgcgaggucuuuauggccguccggggcacguuuaacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugugauggucagaaagugauguugacacaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaaaaguuuuuacuuauucaaugaagcggagcuggaggucaaacuccacguucuagcauuaagcccucugggcgauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagguguccuaagggggacucauggagaacagaaaucuccaguagaacaaaaggguaaaaguccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagangugccagaaaaguuaccacagggauaacuggcuuguggcagunaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaucgcaauaguaauugaacuuaguacgagaggaaccguucauucagauaauugguuuuugcggcugucugaucaggcaacgccgcgaagcuaccaucugcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcgaugauuuuugcccugcacauuuuagauggauacgaauaagacuuuuuagucgcuggaccauagcaggcuggcaacggugcgcuuagcggaaaggcuuugugcgcuugccggcggauagcaaugucaacaugcgcggggauaaauccuuugcauacgacuuagauguacaacggaguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagcucuuguugucugauuugu .......................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[...<.......<<.<<<<<<...>>>>>>.>>.......>.....<<<<<...<<<<<<<<<<<<.<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>....>>>>>>>>....>>>>..>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<<<<<.....<<<......<.....>......>>>..<<<<<<<.<<<<<<<<.<<<<<<<....<<.<<<<<<<......<<<<<<......>>>>>>.......>>>>>>.>.>>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<..<<<<<.....>>>>>..>>>...<<....>>.......<<<<<..<<<<....>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<..<<.........>>..>>>>>....>>>>>>..<<<<<<<<.<<......<<<<..<<<....>>>.>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<<<<<....>>>>>>......>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<...............>>>>><<.<<<<<<<<<<<..<<<<<.<<.....<<<.<<<..<..>.>>>.>>>......>>>>>.>>.......>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<.>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>..............<<<<...>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<.<.<<<<<.................>>>>>.><<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.....<<<<<<.<<<.......<<..........<<<<....>>>>......>>.......<<<<<<...<<<<<<<..<<<......>>>..>>>>>>>.>>>>>>................>>>.>>>>>>..<<<<<<<.............>>....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. .......................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........(((((...((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))).)..))))))))....))))..)))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((((((..(..(((...................)))).((((((((((((((((.(((((((........((((((......((((((......)))))).......))))))......))))).))))))))))........(((....)))....))))))))....)))))))))))).[((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..((((....))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((((((((((....((.(((((((.....(((....(((..(.((((....(((.........)))..)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((..(....((.........))....)......(...(........).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((..((.........))..)))))....))))))(.((((((((.((......((((..(((....))).))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........(.((.((......)).))).....))....))...(((((........)))))]]((((..(((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((..(.((.....(....(..((...(..)..))..).....)....).).).......)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(..(((.....((((....)))).....))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.)))))))....((((.....((((..(((((......)))))...........>..((((...))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).....((((((.(((.......((.(........((((....)))).....))).......((((((...(((((((..(((......)))..))))))).))))))................))).))))))..(((((((..(.......)..))..(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Structure of the vacant Candida albicans 80S ribosome; 25S ribosomal RNA 7pzy 3 121 2.32 RF00001 URS00001B6144_237561 35613268 0003735 0005840 237561 gguugcggccauaucuagcagaaagcaccguuccccguucgaucaaccguaguuaagcugcuaagagcaauaccgaguaguguagugggagaccauacgcgaaacuauugugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Structure of the vacant Candida albicans 80S ribosome; 5S ribosomal RNA 7pzy 4 158 2.32 RF00002 URS0000082EA4_237561 35613268 0003735 0005840 237561 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaauaugaauugcagauauucgugaaucaucgaaucuuugaacgcacauugcgcccucugguauuccggagggcaugccuguuugagcgucguuu .........................................<<<<<<.((.....>>>.....<.<<<<.....))............>>.>>..>...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.(((......]].............).))..)...)))....((.....))(((((((((....)))))))))..................... Structure of the vacant Candida albicans 80S ribosome; 5.8S ribosomal RNA 7pzy 10 16 2.32 RF00005 URS0002335908_237561 35613268 0030533 0006412 237561 ggcagcucugcuacca <<<<<..>>>>>.... .(((....)))..... Structure of the vacant Candida albicans 80S ribosome; Mixture of endogenous E-tRNAs 7pzy A 1692 2.32 RF01960,RF01959,RF00177 URS000059AE3B_237561 35613268 0003735 0005840 237561 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguauacuuggauaaccgugguaauucuagagcuaauacaugcuuaaaaucccgacuguuuggaagggauguauuuauuagauaaaaauuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaaucccgacacggggagguagugacaauaaauaacgauacagguuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaaaagcguauauuaaaguuguugcaguuaaaaagcucguaguugaaccuugggcuuggcuggccgguccuggacccagccgagccuuuccuucuggccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggccuuugcucgaauauauuagcauggaauaauagaauaggacguuaugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucggggguaucaguauucaguugucagaggugaaauucuuggauuuacugaagacuaacuacugcgaaagcauuuaccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgguuguuguucuuuuauugacgcaaucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauagugcugcuagcauuugcugguauagucacuucuuagagggacuaucgauuucaagucgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgaguauaagccuuggccgagaggucugggaaaucuugugaaacuccgucgugcuggggauagagcauuguaauuguugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuacuaccgauugaauggcuuagugaggccuccggauugguuuagggaaccgagaagcuggucaaacuuggucauuuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucau ...<<<<<.[.((((>>>>><<<<.<<<<<<...<.<...<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<..<<..<<....<<<.........<<.....<..<<<.....>>>..>......>>........<<<<<..<<....>>..>>>>><...<<<<<<......[.............>>>>>>.....>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>....>.>.....<<<<...<..>...>>>>......<<..<...........>..>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>>>>>.........<<<((.....<.<<...<<<.<<....<<<<<<<<<<<<............>>>>>>>>>>>>....<<<<<..>>>>>...<<<<<.<<.......<<...<.......>..<<<....>>>....>>......>>.>>..>>>.........<<<..<<<<<<<<<...........].>>>>>>>>>>>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<..<<........>>.>>>>>>>>..>>>...<<..))>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<.....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<.<<<<<<<....>>>>>>>....>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>.....>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<......<<<.<<<<....>>>>.>>>....>>.......>>>>>>>......<....<<<<<<..........>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<..<...<<<<<.......>>>>>...>..>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>....... ....(((..[.[[[..))).((((.((((((...(.(...((.....(((.(((..((....((....((..........))...))[))......(((.......(((..((..((....(((.........((.....(..(((.....)))..)......))........(((((..((....))..)))))(.(.(((((............(......)..))))).)...).(..(((..((((..).))).))).)...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)....).).....((((..(.....).))))......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..[......((([[...(.(.((...(((.((....((((((((((((............))))))))))))....(((((..)))))...(((((.((.(.....((..((.......)).(((....)))....))..)...)).))..))).........(((..(((((.(((.............))).)))))))).....))....((..((.((...((((...(..((((((.....((........))........))))))..)........((....))...))))..)).))...))...)))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..((((((((..(..........).))))))))..)))...((..]]))...))...].))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.........(.(((........))).).......)))))...((.(((...(..((((.....(((.(((((....)))..(.((......)))...)).)))....(((((.((...(((..((((((.(.(((....))).).)..).))))..)))..))..(.((((((.....))))))....)..))))).....)).))......).))))).....).)))))...)).)))).))).(...(((((((......((......(((.((((....)))).)))....)).......)))))))......(....((((((..........))))))....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..((((..(...((((.........))))...)..))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}...... Structure of the vacant Candida albicans 80S ribosome; 18S ribosomal RNA 7q08 1 3209 2.56 RF02540,RF02543 URS0000C2FD9C_237561 35613268 0003735 0005840 237561 ugaccucaaaucagguaggacuacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaacagggauugccucaguagcggcgagugaagcggcaaaagcucaaauuugaaaucuggcgucuuuggcguccgaguuguaauuugaagaagguaucuuugggcccggcucuugucuauguuccuuggaacaggacgucacagagggugagaaucccgugcgaugagaugacccgggucuguguaaaguuccuucgacgagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcuugagaucagacuugguauuuugcaugcugcgguuuaccgggccagcaucgguuuggagcggcaggauaauggcggaggaauguggcacggcuucugcuguguguuauagccucugacgauacugccagccuagaccgaggacugcgguuuuuaccuaggauguuggcauaaugaucuuaagucgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccguacgcguaaugaaagugaacgaaggugggggcccauuagggugcaccaucgaccgauccugauguguucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagaagucuugggguugaaaugaccuuaacuuauucucaaacuuuaaauauguaagaaguccuuguugcuuaauugaacguggacaauugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacgugaaguuaaagugccggaaugcacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcgugcuacuuauacuucaccgugauugcuguuuugacgcuuucacgaguaggcaggcguggaggucagugacgaagccuuugcuguaaagcugggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccaugucaacagcaguuggacauggguuagucgauccuaagagauggggaagcuccguuucaacgugcuugauuuuucaggccaaccaucgaaagggaauccgguuaaaauuccggaacuuggauauggauucuucacggcaacguaacugaauguggagacgucggcgugagcccugggaggaguuaucuuuucuucuuaacagcuuaucacccuggaauugguuuauccggagauggggucuuauggcuggaagagcgcgguaauuuugccgcguccggugcgcuuacgacgguccuugaaaauccacaggaaggaauaguuuucaugccaagucguacucauaaccgcagcaggucuccaagguuaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaaggaucgggugucuugggccuuguguagacgcgaggucuuuauggccguccggggcacguuuaacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugugauggucagaaagugauguugacacaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaaaaguuuuuacuuauucaaugaagcggagcuggaggucaaacuccacguucuagcauuaagcccucugggcgauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagguguccuaagggggacucauggagaacagaaaucuccaguagaacaaaaggguaaaaguccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagangugccagaaaaguuaccacagggauaacuggcuuguggcagunaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaucgcaauaguaauugaacuuaguacgagaggaaccguucauucagauaauugguuuuugcggcugucugaucaggcaacgccgcgaagcuaccaucugcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcgaugauuuuugcccugcacauuuuagauggauacgaauaagacuuuuuagucgcuggaccauagcaggcuggcaacggugcgcuuagcggaaaggcuuugugcgcuugccggcggauagcaaugucaacaugcgcggggauaaauccuuugcauacgacuuagauguacaacggaguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagcucuuguugucugauuugu .......................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..<<<...<.......<<.<<<<<<...>>>>>>.>>.......>.....<<<<<...<<<<<<<<<<<<.<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>....>>>>>>>>....>>>>..>>>>>........<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<<<<<.....<<<....<<<<...>>>>....>>>..<<<<<<<.<<<<<<<<.<<<<<<<....<<.<<<<<<<......<<<<<<......>>>>>>.......>>>>>>.>.>>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<..<<<<<.....>>>>>..>>>...<<....>>.......<<<<<..<<<<....>>>>...>>>>>.<<<<<<<<<..<<....>>>..>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<..<<.........>>..>>>>>....>>>>>><.<<<<<<<<.<<......<<<<..<<<....>>>.>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<<<<<....>>>>>>......>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..[[[..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<...............>>>>><<.<<<<<<<<<<<..<.<<<.<......<<<.<<...<..>..>>.>>>.......>>>>..>.......>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<..<<<<<<<.>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>..............<<<<...>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))......<<<<<<<..<<<<.))))))>>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>....<<<<<<<<..<<<<.<.<<<<<.................>>>>>.><<<<<...<<<<....<<<<<<<<<<]]].>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.....<<<<<<.<<<.......<<..........<<<<....>>>>......>>.......<<<<<<...<<<<<<<..<<<......>>>..>>>>>>>.>>>>>>................>>>.>>>>>>..<<<<<<<.............>>....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. .......................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........(((((...((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))).)..))))))))....))))..)))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((((((..(..(((...................)))).((((((((((((((((.(((((((........((((((......((((.(......).)))).......))))))......))))).))))))))))........(((....)))....))))))))....)))))))))))).[((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..((((....))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((((((((((....((.(((((((.....(((....(((..(.((((....(((.........)))..)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((..(....((.........))....)......(...(........).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((..((.........))..)))))....))))))(.((((((((.((......((((..(((....))).))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........(.((.((......)).))).....))....))...(((((........)))))]]((((..(((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((.(....).)))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((..(..(..(..(.......((...(..)..))........)..).)...).......)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(..(((.....((((....)))).....))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.)))))))....((((.....((((..(((((......)))))...........>..((((...))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).....((((((.(((..(....((.(........((((....)))).....))).......((((((...(((((((..(((......)))..))))))).)))))).............)..))).))))))..(((((((..(.......)..))..(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Structure of Candida albicans 80S ribosome in complex with cycloheximide; 25S ribosomal RNA 7q08 3 121 2.56 RF00001 URS00001B6144_237561 35613268 0003735 0005840 237561 gguugcggccauaucuagcagaaagcaccguuccccguucgaucaaccguaguuaagcugcuaagagcaauaccgaguaguguagugggagaccauacgcgaaacuauugugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Structure of Candida albicans 80S ribosome in complex with cycloheximide; 5S ribosomal RNA 7q08 4 158 2.56 RF00002 URS0000082EA4_237561 35613268 0003735 0005840 237561 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaauaugaauugcagauauucgugaaucaucgaaucuuugaacgcacauugcgcccucugguauuccggagggcaugccuguuugagcgucguuu .........................................<<<<<<.((.....>>>.....<.<<<<.....))............>>.>>..>...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............)).))..)...)))....((.....))(((((((((....)))))))))..................... Structure of Candida albicans 80S ribosome in complex with cycloheximide; 5.8S ribosomal RNA 7q08 A 1692 2.56 RF01960,RF01959,RF00177 URS000059AE3B_237561 35613268 0003735 0005840 237561 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguauacuuggauaaccgugguaauucuagagcuaauacaugcuuaaaaucccgacuguuuggaagggauguauuuauuagauaaaaauuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaaucccgacacggggagguagugacaauaaauaacgauacagguuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaaaagcguauauuaaaguuguugcaguuaaaaagcucguaguugaaccuugggcuuggcuggccgguccuggacccagccgagccuuuccuucuggccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggccuuugcucgaauauauuagcauggaauaauagaauaggacguuaugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucggggguaucaguauucaguugucagaggugaaauucuuggauuuacugaagacuaacuacugcgaaagcauuuaccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgguuguuguucuuuuauugacgcaaucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauagugcugcuagcauuugcugguauagucacuucuuagagggacuaucgauuucaagucgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgaguauaagccuuggccgagaggucugggaaaucuugugaaacuccgucgugcuggggauagagcauuguaauuguugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuacuaccgauugaauggcuuagugaggccuccggauugguuuagggaaccgagaagcuggucaaacuuggucauuuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucau ...<<<<<.[.((((>>>>><<<<.<<<<<<...<.<...<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<..<<..<<....<<<.........<<.....<..<<.......>>..>......>>........<<<<<..<<....>>..>>>>><...<<<<<<....................>>>>>>.....>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>....>.>.....<<<<..........>>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>>.........<<<((.....<.<<...<<<.<<....<<<<<<<<<<<<............>>>>>>>>>>>>....<<<<<..>>>>>....<<<<.<<.......<<...<.......>..<<<....>>>....>>......>>.>>..>>..........<<<..<<<<<<<<<.............>>>>>>>>>>>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<..<<........>>.>>>>>>>>..>>>...<<..))>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<.<<<<<<.<<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<.....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<.<<<<<<<....>>>>>>>....>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>.....>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.>...<<<<<<<......<<......<<<.<<<<....>>>>.>>>....>>.......>>>>>>>......<....<<<<<<..........>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<..<...<<<...........>>>...>..>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>....... ....(((..[.[[[..))).((((.((((((...(.(...((.....(((.(((..((....((....((..........))...))[))......(((.......(((..((..((....(((.........((.....(..(((.....)))..)......))........(((((..(......)..)))))(.(.(((((............(......)..))))).)...).(..(((.(((((..).))))))).)...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)....).).....((((..(.....).))))......(.(.(...........))..).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..[......((([[...(.(.((...(((.((....((((((((((((............))))))))))))....(((((..)))))...(((((.((.(.....((..((.......))..((....)).....))..)...)).))..))).........(((..(((((.(((.............))).)))))))).....))....((..((..(...((((...((.((((((.....((........))........)))))).))........((....))...))))..)..))...))...)))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..((((((((..(..........).))))))))..)))...((..]]))...))...].))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.........(.(((........))))........)))))...((.(((...(..((((.....(((.(((((....)))..(.((......)))...)).)))....(((((.((....((..((((.(.(((((....))))).)....))))..))...))..(.((((((.....))))))....)..))))).....)).))......).))))).....).)))))...)).)))).))).(...(((((((......((......(((.(.((....)).).)))....)).......)))))))......(.....(((((..........))))).....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..((((..(...(.((.........)).)...)..))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}...... Structure of Candida albicans 80S ribosome in complex with cycloheximide; 18S ribosomal RNA 7q0f 1 3209 2.64 RF02540,RF02543 URS0000C2FD9C_237561 35613268 0003735 0005840 237561 ugaccucaaaucagguaggacuacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaacagggauugccucaguagcggcgagugaagcggcaaaagcucaaauuugaaaucuggcgucuuuggcguccgaguuguaauuugaagaagguaucuuugggcccggcucuugucuauguuccuuggaacaggacgucacagagggugagaaucccgugcgaugagaugacccgggucuguguaaaguuccuucgacgagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcuugagaucagacuugguauuuugcaugcugcgguuuaccgggccagcaucgguuuggagcggcaggauaauggcggaggaauguggcacggcuucugcuguguguuauagccucugacgauacugccagccuagaccgaggacugcgguuuuuaccuaggauguuggcauaaugaucuuaagucgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccguacgcguaaugaaagugaacgaaggugggggcccauuagggugcaccaucgaccgauccugauguguucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagaagucuugggguugaaaugaccuuaacuuauucucaaacuuuaaauauguaagaaguccuuguugcuuaauugaacguggacaauugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacgugaaguuaaagugccggaaugcacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcgugcuacuuauacuucaccgugauugcuguuuugacgcuuucacgaguaggcaggcguggaggucagugacgaagccuuugcuguaaagcugggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccaugucaacagcaguuggacauggguuagucgauccuaagagauggggaagcuccguuucaacgugcuugauuuuucaggccaaccaucgaaagggaauccgguuaaaauuccggaacuuggauauggauucuucacggcaacguaacugaauguggagacgucggcgugagcccugggaggaguuaucuuuucuucuuaacagcuuaucacccuggaauugguuuauccggagauggggucuuauggcuggaagagcgcgguaauuuugccgcguccggugcgcuuacgacgguccuugaaaauccacaggaaggaauaguuuucaugccaagucguacucauaaccgcagcaggucuccaagguuaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaaggaucgggugucuugggccuuguguagacgcgaggucuuuauggccguccggggcacguuuaacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugugauggucagaaagugauguugacacaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaaaaguuuuuacuuauucaaugaagcggagcuggaggucaaacuccacguucuagcauuaagcccucugggcgauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagguguccuaagggggacucauggagaacagaaaucuccaguagaacaaaaggguaaaaguccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagangugccagaaaaguuaccacagggauaacuggcuuguggcagunaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaucgcaauaguaauugaacuuaguacgagaggaaccguucauucagauaauugguuuuugcggcugucugaucaggcaacgccgcgaagcuaccaucugcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcgaugauuuuugcccugcacauuuuagauggauacgaauaagacuuuuuagucgcuggaccauagcaggcuggcaacggugcgcuuagcggaaaggcuuugugcgcuugccggcggauagcaaugucaacaugcgcggggauaaauccuuugcauacgacuuagauguacaacggaguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagcucuuguugucugauuugu .......................<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[...........<<.<<<<<<...>>>>>>.>>.............<<<<<...<<<<<<<<<<<<.<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>....>>>>>>>>....>>>>..>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<<<<<.....<<<.....<<.....>>.....>>>..<<<<<<<.<<<<<<<<.<<<<<<<....<<.<<<<<<<......<<<<<<......>>>>>>.......>>>>>>.>.>>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<..<<<<<.....>>>>>..>>>...<<....>>.......<<<<<..<<<<....>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<..<<.........>>..>>>>>....>>>>>><.<<<<<<<<.<<......<<<<..<<<....>>>.>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<<<<<....>>>>>>......>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<.<<<<<<<<<<<..<.<<<.<<<....<<<.<<...<..>..>>.>>>.....>>>>>>..>.......>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<.>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>..............<<<<...>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>..>>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<.<.<<<<<.................>>>>>.><<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.....<<<<<<.<<<.......<<..........<<<<....>>>>......>>.......<<<<<<...<<<<<<<..<<<......>>>..>>>>>>>.>>>>>>................>>>.>>>>>>..<<<<<<<.............>>....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. .......................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........(((((...((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))).)..))))))))....))))..)))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((((((..(..(.(...................).)).((((((((((((((((.(((((((........((((((......((((((......)))))).......))))))......))))).))))))))))........(((....)))....))))))))....)))))))))))).[((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..((((....))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((........)))).)))..).))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((((((((((....((.(((((((.....(((....(((..(.((((....(((.........)))..)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((..(....((.........))....)......(...(........).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((..((.........))..)))))....))))))(.((((((((.((......((((..(((....))).))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...((((((...((.....)).))))))....[[(((.((...((....(((....)))........(.((.((......)).))).....))....))...(((((........)))))]]((((..(((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((..(.((.............((...(..)..)).............))..).......)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(..(((.....((((....)))).....))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.)))))))....((((.....((((..(((((......)))))...........>..((((...))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))....))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).....((((((.(((.......((.(........((((....)))).....))).......((((((...(((((((..(((......)))..))))))).))))))................))).))))))..(((((((..(.......)..))..(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Structure of Candida albicans 80S ribosome in complex with phyllanthoside; 25S ribosomal RNA 7q0f 3 121 2.64 RF00001 URS00001B6144_237561 35613268 0003735 0005840 237561 gguugcggccauaucuagcagaaagcaccguuccccguucgaucaaccguaguuaagcugcuaagagcaauaccgaguaguguagugggagaccauacgcgaaacuauugugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<<............>>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Structure of Candida albicans 80S ribosome in complex with phyllanthoside; 5S ribosomal RNA 7q0f 4 158 2.64 RF00002 URS0000082EA4_237561 35613268 0003735 0005840 237561 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaauaugaauugcagauauucgugaaucaucgaaucuuugaacgcacauugcgcccucugguauuccggagggcaugccuguuugagcgucguuu .........................................<<<<<<.((.....>>>.....<.<<<<.....))............>>.>>..>...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............)).))..)...)))....((.....))(((((((((....)))))))))..................... Structure of Candida albicans 80S ribosome in complex with phyllanthoside; 5.8S ribosomal RNA 7q0f A 1692 2.64 RF01960,RF01959,RF00177 URS000059AE3B_237561 35613268 0003735 0005840 237561 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguauacuuggauaaccgugguaauucuagagcuaauacaugcuuaaaaucccgacuguuuggaagggauguauuuauuagauaaaaauuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaaucccgacacggggagguagugacaauaaauaacgauacagguuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaaaagcguauauuaaaguuguugcaguuaaaaagcucguaguugaaccuugggcuuggcuggccgguccuggacccagccgagccuuuccuucuggccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggccuuugcucgaauauauuagcauggaauaauagaauaggacguuaugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucggggguaucaguauucaguugucagaggugaaauucuuggauuuacugaagacuaacuacugcgaaagcauuuaccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgguuguuguucuuuuauugacgcaaucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauagugcugcuagcauuugcugguauagucacuucuuagagggacuaucgauuucaagucgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgaguauaagccuuggccgagaggucugggaaaucuugugaaacuccgucgugcuggggauagagcauuguaauuguugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuacuaccgauugaauggcuuagugaggccuccggauugguuuagggaaccgagaagcuggucaaacuuggucauuuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucau ...<<<<<.[.((((>>>>><<<<.<<<<<<...<.<...<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<..<<..<<....<<<.........<<.....<..<<.......>>..>......>>........<<<<<..<<....>>..>>>>><...<<<<<<....................>>>>>>.....>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>....>.>.....<<<<...<..>...>>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>>.........<<<((.....<.<<...<<<.<<....<<<<<<<<<<<<............>>>>>>>>>>>>....<<<<<..>>>>>...<<<<<.<<.......<<...<.......>..<<<....>>>....>>......>>.>>..>>>.........<<<..<<<<<<<<<.............>>>>>>>>>>>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<..<<........>>.>>>>>>>>..>>>...<<..))>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<.....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<.<<<<<<<....>>>>>>>....>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>.....>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<......<<<.<<<<....>>>>.>>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<..<...<<<<.........>>>>...>..>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>....... ....(((..[.[[[..))).((((.((((((...(.(...((.....(((.(((..((....((....((..........))...))[))......(((.......(((..((..((....(((.........((.....(..(((.....)))..)......))........(((((..(......)..)))))(.(.(((((............(......)..))))).)...).(..(((..((((..).))).))).)...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)....).).....((((..(.....).))))......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..[......((([[...(.(.((...(((.((....((((((((((((............))))))))))))....(((((..)))))...(((((.((.(.....((..((.......))..((....)).....))..)...)).))..))).........(((..(((((.(((.............))).)))))))).....))....((..((.((...((((...((.((((((.....((........))........)))))).))........((....))...))))..)).))...))...)))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..((((((((..((........)).))))))))..)))...((..]]))...))...].))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.........(.(((........))))........)))))...((.(((...(..((((.....(((.(((((....)))..(.((......)))...)).)))....(((((.((...(((..((((.(.(((((....))))).)....))))..)))..))..(.((((((.....))))))....)..))))).....)).))......).))))).....).)))))...)).)))).))).(...(((((((......((......((..(.((....)).)..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..((((..(...((((.........))))...)..))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}...... Structure of Candida albicans 80S ribosome in complex with phyllanthoside; 18S ribosomal RNA 7q0p 1 3209 2.77 RF02540,RF02543 URS0000C2FD9C_237561 35613268 0003735 0005840 237561 ugaccucaaaucagguaggacuacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaacagggauugccucaguagcggcgagugaagcggcaaaagcucaaauuugaaaucuggcgucuuuggcguccgaguuguaauuugaagaagguaucuuugggcccggcucuugucuauguuccuuggaacaggacgucacagagggugagaaucccgugcgaugagaugacccgggucuguguaaaguuccuucgacgagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcuugagaucagacuugguauuuugcaugcugcgguuuaccgggccagcaucgguuuggagcggcaggauaauggcggaggaauguggcacggcuucugcuguguguuauagccucugacgauacugccagccuagaccgaggacugcgguuuuuaccuaggauguuggcauaaugaucuuaagucgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccguacgcguaaugaaagugaacgaaggugggggcccauuagggugcaccaucgaccgauccugauguguucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagaagucuugggguugaaaugaccuuaacuuauucucaaacuuuaaauauguaagaaguccuuguugcuuaauugaacguggacaauugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacgugaaguuaaagugccggaaugcacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcgugcuacuuauacuucaccgugauugcuguuuugacgcuuucacgaguaggcaggcguggaggucagugacgaagccuuugcuguaaagcugggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccaugucaacagcaguuggacauggguuagucgauccuaagagauggggaagcuccguuucaacgugcuugauuuuucaggccaaccaucgaaagggaauccgguuaaaauuccggaacuuggauauggauucuucacggcaacguaacugaauguggagacgucggcgugagcccugggaggaguuaucuuuucuucuuaacagcuuaucacccuggaauugguuuauccggagauggggucuuauggcuggaagagcgcgguaauuuugccgcguccggugcgcuuacgacgguccuugaaaauccacaggaaggaauaguuuucaugccaagucguacucauaaccgcagcaggucuccaagguuaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaaggaucgggugucuugggccuuguguagacgcgaggucuuuauggccguccggggcacguuuaacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugugauggucagaaagugauguugacacaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaaaaguuuuuacuuauucaaugaagcggagcuggaggucaaacuccacguucuagcauuaagcccucugggcgauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagguguccuaagggggacucauggagaacagaaaucuccaguagaacaaaaggguaaaaguccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagangugccagaaaaguuaccacagggauaacuggcuuguggcagunaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaucgcaauaguaauugaacuuaguacgagaggaaccguucauucagauaauugguuuuugcggcugucugaucaggcaacgccgcgaagcuaccaucugcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcgaugauuuuugcccugcacauuuuagauggauacgaauaagacuuuuuagucgcuggaccauagcaggcuggcaacggugcgcuuagcggaaaggcuuugugcgcuugccggcggauagcaaugucaacaugcgcggggauaaauccuuugcauacgacuuagauguacaacggaguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagcucuuguugucugauuugu .......................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[...<.......<<.<<<<<<...>>>>>>.>>.......>.....<<<<<...<<<<<<<<<<<<.<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>....>>>>>>>>....>>>>..>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<<<<<.....<<<......<.....>......>>>..<<<<<<<.<<<<<<<<.<<<<<<<....<<.<<<<<<<......<<<<<<......>>>>>>.......>>>>>>.>.>>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<..<<<<<.....>>>>>..>>>...<<....>>.......<<<<<..<<<<....>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<..<<.........>>..>>>>>....>>>>>>..<<<<<<<<.<<......<<<<..<<<....>>>.>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<<<<<....>>>>>>......>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<...............>>>>><<.<<<<<<<<<<<..<<<<<.<<.....<<<.<<<..<..>.>>>.>>>......>>>>>.>>.......>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<.>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>..............<<<<...>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<.<.<<<<<.................>>>>>.><<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.....<<<<<<.<<<.......<<..........<<<<....>>>>......>>.......<<<<<<...<<<<<<<..<<<......>>>..>>>>>>>.>>>>>>................>>>.>>>>>>..<<<<<<<.............>>....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. .......................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........(((((...((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))).)..))))))))....))))..)))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((((((..(..(.(...................).)).((((((((((((((((.(((((((........((((((......((((((......)))))).......))))))......))))).))))))))))........(((....)))....))))))))....)))))))))))).[((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..((((....))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((((((((((....((.(((((((.....(((....(((..(.((((....(((.........)))..)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((..(....((.........))....)......(...(........).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((..((.........))..)))))....))))))(.((((((((.((......((((..(((....))).))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........(.((.((......)).))).....))....))...(((((........)))))]]((((..(((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((..(.((.....(....(..((...(..)..))..).....)....).).).......)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(..(((.....((((....)))).....))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.)))))))....((((.....((((..(((((......)))))...........>..((((...))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).....((((((.(((.......((.(........((((....)))).....))).......((((((...(((((((..(((......)))..))))))).))))))................))).))))))..(((((((..(.......)..))..(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Structure of the Candida albicans 80S ribosome in complex with anisomycin; 25S ribosomal RNA 7q0p 3 121 2.77 RF00001 URS00001B6144_237561 35613268 0003735 0005840 237561 gguugcggccauaucuagcagaaagcaccguuccccguucgaucaaccguaguuaagcugcuaagagcaauaccgaguaguguagugggagaccauacgcgaaacuauugugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Structure of the Candida albicans 80S ribosome in complex with anisomycin; 5S ribosomal RNA 7q0p 4 158 2.77 RF00002 URS0000082EA4_237561 35613268 0003735 0005840 237561 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaauaugaauugcagauauucgugaaucaucgaaucuuugaacgcacauugcgcccucugguauuccggagggcaugccuguuugagcgucguuu .........................................<<<<<<.((.....>>>.....<.<<<<.....))............>>.>>..>...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.(((......]].............).))..)...)))....((.....))(((((((((....)))))))))..................... Structure of the Candida albicans 80S ribosome in complex with anisomycin; 5.8S ribosomal RNA 7q0p 10 14 2.77 RF00005 URS0000D22C51_237561 35613268 0030533 0006412 237561 ggcagcugcuacca <<<<..>>>>.... .(((..)))..... Structure of the Candida albicans 80S ribosome in complex with anisomycin; Mixture of endogenous E-tRNA 7q0p A 1692 2.77 RF01960,RF01959,RF00177 URS000059AE3B_237561 35613268 0003735 0005840 237561 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguauacuuggauaaccgugguaauucuagagcuaauacaugcuuaaaaucccgacuguuuggaagggauguauuuauuagauaaaaauuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaaucccgacacggggagguagugacaauaaauaacgauacagguuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaaaagcguauauuaaaguuguugcaguuaaaaagcucguaguugaaccuugggcuuggcuggccgguccuggacccagccgagccuuuccuucuggccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggccuuugcucgaauauauuagcauggaauaauagaauaggacguuaugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucggggguaucaguauucaguugucagaggugaaauucuuggauuuacugaagacuaacuacugcgaaagcauuuaccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgguuguuguucuuuuauugacgcaaucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauagugcugcuagcauuugcugguauagucacuucuuagagggacuaucgauuucaagucgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgaguauaagccuuggccgagaggucugggaaaucuugugaaacuccgucgugcuggggauagagcauuguaauuguugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuacuaccgauugaauggcuuagugaggccuccggauugguuuagggaaccgagaagcuggucaaacuuggucauuuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucau ...<<<<<.[.((((>>>>><<<<.<<<<<<...<.<...<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<..<<..<<....<<<.........<<.....<..<<<.....>>>..>......>>........<<<<<..<<....>>..>>>>><...<<<<<<....................>>>>>>.....>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>....>.>.....<<<<...<..>...>>>>......<<..<...........>..>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>>>>>.........<<<((.....<.<<...<<<.<<....<<<<<<<<<<<<............>>>>>>>>>>>>....<<<<<..>>>>>...<<<<<.<<.......<<...<.......>..<<<....>>>....>>......>>.>>..>>>.........<<<..<<<<<<<<<.............>>>>>>>>>>>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<..<<........>>.>>>>>>>>..>>>...<<..))>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<.....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<.<<<<<<<....>>>>>>>....>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>.....>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<......<<<.<<<<....>>>>.>>>....>>.......>>>>>>>......<....<<<<<<..........>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<..<...<<<<<.......>>>>>...>..>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>....... ....(((..[.[[[..))).((((.((((((...(.(...((.....(((.(((..((....((....((..........))...))[))......(((.......(((..((..((....(((.........((.....(..(((.....)))..)......))........(((((..((....))..)))))(.(.(((((............(......)..))))).)...).(..(((..((((..).))).))).)...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)....).).....((((..(.....).))))......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..[......((([[...(.(.((...(((.((....((((((((((((............))))))))))))....(((((..)))))...(((((.((.(.....((..((.......)).(((....)))....))..)...)).))..))).........(((..(((((.(((.............))).)))))))).....))....((..((.((...((((...(..((((((.....((........))........))))))..)........((....))...))))..)).))...))...)))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..((((((((..(..........).))))))))..)))...((..]]))...))...].))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.........(.(((........))).).......)))))...((.(((...(..((((.....(((.(((((....)))..(.((......)))...)).)))....(((((.((...(((..((((((.(.(((....))).).)..).))))..)))..))..(.((((((.....))))))....)..))))).....)).))......).))))).....).)))))...)).)))).))).(...(((((((......((......(((.((((....)))).)))....)).......)))))))......(....((((((..........))))))....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..((((..(...((((.........))))...)..))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}...... Structure of the Candida albicans 80S ribosome in complex with anisomycin; 18S ribosomal RNA 7q0r 1 3209 2.67 RF02540,RF02543 URS0000C2FD9C_237561 35613268 0003735 0005840 237561 ugaccucaaaucagguaggacuacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaacagggauugccucaguagcggcgagugaagcggcaaaagcucaaauuugaaaucuggcgucuuuggcguccgaguuguaauuugaagaagguaucuuugggcccggcucuugucuauguuccuuggaacaggacgucacagagggugagaaucccgugcgaugagaugacccgggucuguguaaaguuccuucgacgagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcuugagaucagacuugguauuuugcaugcugcgguuuaccgggccagcaucgguuuggagcggcaggauaauggcggaggaauguggcacggcuucugcuguguguuauagccucugacgauacugccagccuagaccgaggacugcgguuuuuaccuaggauguuggcauaaugaucuuaagucgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccguacgcguaaugaaagugaacgaaggugggggcccauuagggugcaccaucgaccgauccugauguguucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagaagucuugggguugaaaugaccuuaacuuauucucaaacuuuaaauauguaagaaguccuuguugcuuaauugaacguggacaauugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacgugaaguuaaagugccggaaugcacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcgugcuacuuauacuucaccgugauugcuguuuugacgcuuucacgaguaggcaggcguggaggucagugacgaagccuuugcuguaaagcugggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccaugucaacagcaguuggacauggguuagucgauccuaagagauggggaagcuccguuucaacgugcuugauuuuucaggccaaccaucgaaagggaauccgguuaaaauuccggaacuuggauauggauucuucacggcaacguaacugaauguggagacgucggcgugagcccugggaggaguuaucuuuucuucuuaacagcuuaucacccuggaauugguuuauccggagauggggucuuauggcuggaagagcgcgguaauuuugccgcguccggugcgcuuacgacgguccuugaaaauccacaggaaggaauaguuuucaugccaagucguacucauaaccgcagcaggucuccaagguuaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaaggaucgggugucuugggccuuguguagacgcgaggucuuuauggccguccggggcacguuuaacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugugauggucagaaagugauguugacacaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaaaaguuuuuacuuauucaaugaagcggagcuggaggucaaacuccacguucuagcauuaagcccucugggcgauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagguguccuaagggggacucauggagaacagaaaucuccaguagaacaaaaggguaaaaguccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagangugccagaaaaguuaccacagggauaacuggcuuguggcagunaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaucgcaauaguaauugaacuuaguacgagaggaaccguucauucagauaauugguuuuugcggcugucugaucaggcaacgccgcgaagcuaccaucugcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcgaugauuuuugcccugcacauuuuagauggauacgaauaagacuuuuuagucgcuggaccauagcaggcuggcaacggugcgcuuagcggaaaggcuuugugcgcuugccggcggauagcaaugucaacaugcgcggggauaaauccuuugcauacgacuuagauguacaacggaguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagcucuuguugucugauuugu .......................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[...<.......<<.<<<<<<...>>>>>>.>>.......>.....<<<<<...<<<<<<<<<<<<.<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>....>>>>>>>>....>>>>..>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<<<<<.....<<<......<.....>......>>>..<<<<<<<.<<<<<<<<.<<<<<<<....<<.<<<<<<<......<<<<<<......>>>>>>.......>>>>>>.>.>>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<..<<<<<.....>>>>>..>>>...<<....>>.......<<<<<..<<<<....>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<..<<.........>>..>>>>>....>>>>>>..<<<<<<<<.<<......<<<<..<<<....>>>.>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<<<<<....>>>>>>......>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<...............>>>>><<.<<<<<<<<<<<..<<<<<.<<.....<<<.<<<..<..>.>>>.>>>......>>>>>.>>.......>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<.>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>..............<<<<...>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<.<.<<<<<.................>>>>>.><<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.....<<<<<<.<<<.......<<..........<<<<....>>>>......>>.......<<<<<<...<<<<<<<..<<<......>>>..>>>>>>>.>>>>>>................>>>.>>>>>>..<<<<<<<.............>>....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. .......................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........(((((...((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))).)..))))))))....))))..)))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((((((..(..(.(...................).)).((((((((((((((((.(((((((........((((((......((((((......)))))).......))))))......))))).))))))))))........(((....)))....))))))))....)))))))))))).[((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..((((....))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((((((((((....((.(((((((.....(((....(((..(.((((....(((.........)))..)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((..(....((.........))....)......(...(........).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((..((.........))..)))))....))))))(.((((((((.((......((((..(((....))).))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........(.((.((......)).))).....))....))...(((((........)))))]]((((..(((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((..(.((.....(....(..((...(..)..))..).....)....).).).......)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(..(((.....((((....)))).....))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.)))))))....((((.....((((..(((((......)))))...........>..((((...))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).....((((((.(((.......((.(........((((....)))).....))).......((((((...(((((((..(((......)))..))))))).))))))................))).))))))..(((((((..(.......)..))..(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Structure of the Candida albicans 80S ribosome in complex with blasticidin s; 25S ribosomal RNA 7q0r 3 121 2.67 RF00001 URS00001B6144_237561 35613268 0003735 0005840 237561 gguugcggccauaucuagcagaaagcaccguuccccguucgaucaaccguaguuaagcugcuaagagcaauaccgaguaguguagugggagaccauacgcgaaacuauugugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Structure of the Candida albicans 80S ribosome in complex with blasticidin s; 5S ribosomal RNA 7q0r 4 158 2.67 RF00002 URS0000082EA4_237561 35613268 0003735 0005840 237561 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaauaugaauugcagauauucgugaaucaucgaaucuuugaacgcacauugcgcccucugguauuccggagggcaugccuguuugagcgucguuu .........................................<<<<<<.((.....>>>.....<.<<<<.....))............>>.>>..>...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.(((......]].............).))..)...)))....((.....))(((((((((....)))))))))..................... Structure of the Candida albicans 80S ribosome in complex with blasticidin s; 5.8S ribosomal RNA 7q0r 10 14 2.67 RF00005 URS0000D22C51_237561 35613268 0030533 0006412 237561 ggcagcugcuacca <<<<..>>>>.... .(((..)))..... Structure of the Candida albicans 80S ribosome in complex with blasticidin s; Mixture of the endogenous E-tRNA 7q0r A 1692 2.67 RF01960,RF01959,RF00177 URS000059AE3B_237561 35613268 0003735 0005840 237561 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguauacuuggauaaccgugguaauucuagagcuaauacaugcuuaaaaucccgacuguuuggaagggauguauuuauuagauaaaaauuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaaucccgacacggggagguagugacaauaaauaacgauacagguuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaaaagcguauauuaaaguuguugcaguuaaaaagcucguaguugaaccuugggcuuggcuggccgguccuggacccagccgagccuuuccuucuggccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggccuuugcucgaauauauuagcauggaauaauagaauaggacguuaugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucggggguaucaguauucaguugucagaggugaaauucuuggauuuacugaagacuaacuacugcgaaagcauuuaccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgguuguuguucuuuuauugacgcaaucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauagugcugcuagcauuugcugguauagucacuucuuagagggacuaucgauuucaagucgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgaguauaagccuuggccgagaggucugggaaaucuugugaaacuccgucgugcuggggauagagcauuguaauuguugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuacuaccgauugaauggcuuagugaggccuccggauugguuuagggaaccgagaagcuggucaaacuuggucauuuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucau ...<<<<<.[.((((>>>>><<<<.<<<<<<...<.<...<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<..<<..<<....<<<.........<<.....<..<<<.....>>>..>......>>........<<<<<..<<....>>..>>>>><...<<<<<<....................>>>>>>.....>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>....>.>.....<<<<...<..>...>>>>......<<..<...........>..>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>>>>>.........<<<((.....<.<<...<<<.<<....<<<<<<<<<<<<............>>>>>>>>>>>>....<<<<<..>>>>>...<<<<<.<<.......<<...<.......>..<<<....>>>....>>......>>.>>..>>>.........<<<..<<<<<<<<<.............>>>>>>>>>>>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<..<<........>>.>>>>>>>>..>>>...<<..))>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<.....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<.<<<<<<<....>>>>>>>....>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>.....>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<......<<<.<<<<....>>>>.>>>....>>.......>>>>>>>......<....<<<<<<..........>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<..<...<<<<<.......>>>>>...>..>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>....... ....(((..[.[[[..))).((((.((((((...(.(...((.....(((.(((..((....((....((..........))...))[))......(((.......(((..((..((....(((.........((.....(..(((.....)))..)......))........(((((..((....))..)))))(.(.(((((............(......)..))))).)...).(..(((..((((..).))).))).)...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)....).).....((((..(.....).))))......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..[......((([[...(.(.((...(((.((....((((((((((((............))))))))))))....(((((..)))))...(((((.((.(.....((..((.......)).(((....)))....))..)...)).))..))).........(((..(((((.(((.............))).)))))))).....))....((..((.((...((((...(..((((((.....((........))........))))))..)........((....))...))))..)).))...))...)))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..((((((((..(..........).))))))))..)))...((..]]))...))...].))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.........(.(((........))).).......)))))...((.(((...(..((((.....(((.(((((....)))..(.((......)))...)).)))....(((((.((...(((..((((((.(.(((....))).).)..).))))..)))..))..(.((((((.....))))))....)..))))).....)).))......).))))).....).)))))...)).)))).))).(...(((((((......((......(((.((((....)))).)))....)).......)))))))......(....((((((..........))))))....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..((((..(...((((.........))))...)..))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}...... Structure of the Candida albicans 80S ribosome in complex with blasticidin s; 18S ribosomal RNA 7q4k AA 1534 3.0 RF00177,RF01959,RF02542,RF01960 URS000081169C_562 37393329 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<......>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>..<<.<<<<<......<<<...<<.<.......>>>...>>.>........>>>>>....>>.<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<.....<<<<....>>>>......<......>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<...<<....>>..>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((((((.(..).)))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((.(....).))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((.(...(...((.((((.(......).)).)))).....)....).)))....)).(((.([[[...(((((.....((.]]])).......)))))).)))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.((.((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((....(((((....)))))......(....)...))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....))))))))..)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))).))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Erythromycin-stalled Escherichia coli 70S ribosome with streptococcal MsrDL nascent chain; 16S rRNA 7q4k BA 2897 3.0 RF02541 URS000080E25C_562 37393329 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<<..>>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<.....>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<<..<<<<.......>>>>..>>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<......>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<<.<<....>>..>>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((.(.....)..))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(...((......)).).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((((......))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((((..(((.((((.(.........((.((..(((......((((((((....))))))))...)))............)).))).)))).)))..))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).).....((.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..))....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Erythromycin-stalled Escherichia coli 70S ribosome with streptococcal MsrDL nascent chain; 23S rRNA 7q4k BB 120 3.0 RF00001 URS0000049E57_562 37393329 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Erythromycin-stalled Escherichia coli 70S ribosome with streptococcal MsrDL nascent chain; 5S rRNA 7q4k D2 76 3.0 RF00005 URS000261775C_562 37393329 0030533 0006412 562 ggcuacgnagcucagnnngnnagagcacaucacunaunaugaugggncacaggnucgaaucccgucguagccacca <<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>....<<.<<.......>>.>>>>>>>>>.... (((((((..((((.........)))).((((.........))))....((.((.......)).))))))))).... Erythromycin-stalled Escherichia coli 70S ribosome with streptococcal MsrDL nascent chain; Met-tRNA (P site) 7q4k D3 75 3.0 RF00005 URS00005AA258_562 37393329 0030533 0006412 562 gcccgganagcucagncggnagagcaggggauugaaaauccccgugccuuggnucgauuccgaguccgggcacca <<<<<<...<<<<........>>>>.<<<<<<.....>>>>>>....<<<<<.......>>>>>.>>>>>>.... (((((....((((........)))).((((.........))))....((.((.......)).))..))))).... Erythromycin-stalled Escherichia coli 70S ribosome with streptococcal MsrDL nascent chain; Phe-tRNA (E site) 7q4o 2 35 2.1 RF00004 URS00003EE995_9606 34822310 0045131 0000348 0005686 9606 aaguguaguaunuguucunaucaguuuaauaunug .....................<<<........>>> .....................(((........))) Substrate-bound A-like U2 snRNP; U2 snRNA 7q4o h 13 2.1 URS00023358E5_32630 34822310 32630 cagauacuaacac ............. ............. Substrate-bound A-like U2 snRNP; BPS oligo 7q7x A 14 2.8 URS00023358DC_32630 35301481 32630 ccacugngagcuuc .............. .............. Crystal structure of the methyltransferase-ribozyme 1 (with 1-methyl-adenosine); RNA 1 7q7x B 24 2.8 URS00023358C9_32630 35301481 32630 ggaagcucugaccgacccccagcc ........................ ........................ Crystal structure of the methyltransferase-ribozyme 1 (with 1-methyl-adenosine); RNA 2 7q7x C 24 2.8 URS00023358B5_32630 35301481 32630 gcugggacaacuagacauacagug ........................ ........................ Crystal structure of the methyltransferase-ribozyme 1 (with 1-methyl-adenosine); RNA 3 7q7y A 14 2.9 URS00023358DF_32630 35301481 32630 ccacugngaguuuc .............. .............. Crystal structure of the methyltransferase-ribozyme 1 (1-benzyl-adenosine derivative); RNA 1 7q7y B 24 2.9 URS00023358C9_32630 35301481 32630 ggaagcucugaccgacccccagcc ........................ ........................ Crystal structure of the methyltransferase-ribozyme 1 (1-benzyl-adenosine derivative); RNA 2 7q7y C 24 2.9 URS00023358B5_32630 35301481 32630 gcugggacaacuagacauacagug ........................ ........................ Crystal structure of the methyltransferase-ribozyme 1 (1-benzyl-adenosine derivative); RNA 3 7q7z A 14 3.26 URS00023358DC_32630 35301481 32630 ccacugngagcuuc .............. .............. Crystal structure of the methyltransferase-ribozyme 1 (with 1-benzylamine-adenosine); RNA 1 7q7z B 24 3.26 URS00023358C9_32630 35301481 32630 ggaagcucugaccgacccccagcc ........................ ........................ Crystal structure of the methyltransferase-ribozyme 1 (with 1-benzylamine-adenosine); RNA 2 7q7z C 24 3.26 URS00023358B5_32630 35301481 32630 gcugggacaacuagacauacagug ........................ ........................ Crystal structure of the methyltransferase-ribozyme 1 (with 1-benzylamine-adenosine); RNA 3 7q7z D 14 3.26 URS00023358DC_32630 35301481 32630 ccacugngagcuuc .............. .............. Crystal structure of the methyltransferase-ribozyme 1 (with 1-benzylamine-adenosine); RNA 1 7q7z E 24 3.26 URS00023358C9_32630 35301481 32630 ggaagcucugaccgacccccagcc ........................ ........................ Crystal structure of the methyltransferase-ribozyme 1 (with 1-benzylamine-adenosine); RNA 2 7q7z F 24 3.26 URS00023358B5_32630 35301481 32630 gcugggacaacuagacauacagug ........................ ........................ Crystal structure of the methyltransferase-ribozyme 1 (with 1-benzylamine-adenosine); RNA 3 7q80 A 14 3.14 URS00023358DC_32630 35301481 32630 ccacugngagcuuc .............. .............. Crystal structure of the methyltransferase-ribozyme 1, no Magnesium condition (with 1-methyl-adenosine); RNA 1 7q80 B 24 3.14 URS00023358C9_32630 35301481 32630 ggaagcucugaccgacccccagcc ........................ ........................ Crystal structure of the methyltransferase-ribozyme 1, no Magnesium condition (with 1-methyl-adenosine); RNA 2 7q80 C 24 3.14 URS00023358B5_32630 35301481 32630 gcugggacaacuagacauacagug ........................ ........................ Crystal structure of the methyltransferase-ribozyme 1, no Magnesium condition (with 1-methyl-adenosine); RNA 3 7q80 D 14 3.14 URS00023358DC_32630 35301481 32630 ccacugngagcuuc .............. .............. Crystal structure of the methyltransferase-ribozyme 1, no Magnesium condition (with 1-methyl-adenosine); RNA 1 7q80 E 24 3.14 URS00023358C9_32630 35301481 32630 ggaagcucugaccgacccccagcc ........................ ........................ Crystal structure of the methyltransferase-ribozyme 1, no Magnesium condition (with 1-methyl-adenosine); RNA 2 7q80 F 24 3.14 URS00023358B5_32630 35301481 32630 gcugggacaacuagacauacagug ........................ ........................ Crystal structure of the methyltransferase-ribozyme 1, no Magnesium condition (with 1-methyl-adenosine); RNA 3 7q81 A 14 2.85 URS00023358DF_32630 35301481 32630 ccacugngagunuc .............. .............. Crystal structure of the methyltransferase-ribozyme 1, 2'-Selenomethyl-Uridine modified (with 1-methyl-adenosine); RNA1 7q81 B 24 2.85 URS00023358C9_32630 35301481 32630 ggaagcucugaccgacccccagcc ........................ ........................ Crystal structure of the methyltransferase-ribozyme 1, 2'-Selenomethyl-Uridine modified (with 1-methyl-adenosine); RNA 2 7q81 C 24 2.85 URS00023358B5_32630 35301481 32630 gcugggacaacuagacauacagug ........................ ........................ Crystal structure of the methyltransferase-ribozyme 1, 2'-Selenomethyl-Uridine modified (with 1-methyl-adenosine); RNA 3 7q82 A 14 2.95 URS00023358DC_32630 35301481 32630 ccacugngagcuuc .............. .............. Crystal structure of the methyltransferase-ribozyme 1, Thallium derivative (with 1-methyl-adenosine); RNA 1 7q82 B 24 2.95 URS00023358C9_32630 35301481 32630 ggaagcucugaccgacccccagcc ........................ ........................ Crystal structure of the methyltransferase-ribozyme 1, Thallium derivative (with 1-methyl-adenosine); RNA 2 7q82 C 24 2.95 URS00023358B5_32630 35301481 32630 gcugggacaacuagacauacagug ........................ ........................ Crystal structure of the methyltransferase-ribozyme 1, Thallium derivative (with 1-methyl-adenosine); RNA 3 7qca L50 2499 2.79 RF02543 URS00026177A1_1358809 0003735 0005840 1358809 auaccacacacaagggaucguuuggcuccugggacgaggaagggcgcagcagagagcgauaugugugggagcagcagcaaugaccacacguccccgaauacagcauagugcuggaguacuccuuggaauuaagcauaugaguaaaggaaggaaaagaaacuaacgaggauucccguaguagcggcgagugaacagggaacaguccaacaguguaauucucaaaugagaaguugucaaaaggaagaagaugugaaucagaaagaaaagcugaacgauacagggugauagucccguagugucuucuuacauacggugaguagcugugcucgguaaugcacagugaagagguggcagugugcaucuaagacuaaauacaacaggagaccgauagcaaagaaguagguugaccgaaaacagugaaauuguguguggacccgaauggaucgggcccgucuugaaacacggaccaaggagugcacauacacugcaaguugagcagaggaagucugugaggcguagugaagacggaaagcagugugagugcgacccgauagacuugugaacuauaccuuguugcugugaaggcuggcgaaagccagcuggaggcggcaagccguauugaucugcaaaucauuggcguaagcaggguauaggggcgaaagaccaaucgaacagucuaguugcugguucccuccgaaaugucuaucaggacagcgcgcacgcagagagaagcaagguagagcaugggccgguauccuuaaggagacggacgaacugcgaaugugcuuuucuucuaugcaagcguagugggcgaguucugguaagcaggacuggcgaagaggaaugaaccuggcacugugcuaaggaacccaaugucuggacagagaccgaaagagguaggugaauaaaauucaucugcucugaaaauugauggcgcuuaccagacauccgaugcacaguuagcagguaggagggcgugugucuacuggcgaagguaccgagugaucggugguggagguagaugcagagcagaucuuggugguaguagcgauaauuugucuucagcggcaaagacugaggaggagaaggguuucuucucauaagaagagugagccgggucuaagcgaguguguagaagcaugagcgaaggagaaacagguugauauuccugugccugugcugucguacggcaacguguauuagcuugucgacacgaacaucuagacaaagcagaaacaccuuuucuguucaaggggaaaaagaccacugagacggaucaucuggcgacgugguuuuauaucugugaccaggccugagccugguuuguugaggauggucguccaugaaaagacaacuauauggcagcacaguccguaccaaccguaucaggacuccaaggugaagagccucuaguggauguuuuacacauguaagggaauucggcaaaauggaugcguaacuucgggagaaguauugguucaauugugaacucauugugacaaggggaaucugacuguuuaguaaaaacauagcuucaugaagagagaugaagugaguucugcccggugcucggucgugacacggaggaaaugccagaaagcacggguuaacggcgggaguaacuaugacucucuuaagguagccaaacgccucgucauuuaaauggugacgcgcaugaauggaaugacgagauucccacugucccuacauguagacuagcgaacccauuuccaggggaacgggccuggacggccagcggggaaagaagacccuguugagcuugacucuaguguggccaaguugugacgauugaggcgagcgccaugaucaucacgacacacuuguuuaaggacaaaggccagauggggaguuuggcuggggcgguacgaccacagaaucagaacguggucgaccgaagguacucacagcgagacgagaacacucguguagagcauaaggacuaaagagugccugagugugagcacuacugcuugcaugaggggaaacccgggccuagcgauccuacgcauacgagacacuuguggcgugggugucagaaaaguuaccacagggauaacuggcuuguggccgccgagcguagaaagcgacgcggcuuuuugauucuucgaugucggcucuuccuagcauggccaugcagccguggcgaaguguuggauuguucacccacuaacagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuauccuacuguccaaacaguugaagggaguguggauuaguacgaaaggaaacccacacgugaccucuggugcagcgggugugcggaagugcaacugccaugcuacgucuccucaagcauagcuggaagccucuaagcuagaaaugaguccugacucuggaagacggccgggaagacgacccguaguuaacagcgguguuguacgauaugagcuuucuauuguaguagcgaguauuugagacacugguuguuaccaccgucgu ....<<<<<<<<<......((..((<<<<<<...<......<<<<<<.((.....>>>....<<<<<<..<..))..>.....>>>>>>...>>>.....<<<<<...>>>>>>....<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..<<<...........<<<<<<..>>>>>>............<<<<<<<<<<...<<<<.........>>>>((......<<<.....))>>>...>>>>>>>>>>..............<<<<<<<........>>>>>>>....<<<<<..<<<<<.>>>>>..>>>.........>>>>>>.))...............<<....>>....)).......>>>>>>>>>..<<<<<.....>>>>>.<<<<........>>>><<<<<<....<<<<.<<<<<<<<..<<<..<<<<<.....>>>>>..>>>...<<....>>.....>>>>>>>>.>>>>..<<.<..<<<<<.<<.....<<<<<<<<<<<<<<....<<<<<<<....>>>>>>>.....>>>>>.<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<..<<<<<.<<<<<<<.....<<<......<<<...<<<<..>>>>..>>>.....>>.>.....>>>>>..>>>>>..>>..>>>>.>>..<<.<<<<<<<.....>>>>>>>.>>....<<<......>>>...<<<<<<<...<<<.((...<<<<<<<.....<......<<.<<<<<<<<<<<...>>>>>>>>>>>>>..........))..>...>>>>>>>>>>...>>>>>>>.........>>>>>><.<<<<<<<<<<......<.<<<<<<....>>>>>>.>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<......>>>>>>.<<<.....<<<<..<<...<<<<<<....>>>>>>....((<<<<<<...<<..<<<<......>>>>..>>....>>...<<<<<........>>>>>))<<<<<<<<<<..<<<....>>>....<<<.<<<<<...<<<<.<<<<..<<<<<<<<<<<<...[[..>>>>>><<..<<<..<.<<<<<<<<.....<<<<...>>>>.....>>>>>>>>.>.>>>..>><<<<<<....>>>>>>>>>>>>...>>>>.>>>>.........>>>>>>>>...>>>>>>>>>>>>>>..>>..<<......>>.>>>>.<<<<.....>>>>..>>>....<<.....<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<....>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<........>>>>>>>..<<<..<<<..<<<<<<<.<.<<.....<<........>>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>.....>>.>..>>.>>>>>>>..>..>>.>>>>>>>..>>..>>....>>....<<<<<........>>>>>..[[.<<<..<<<.[[......<<<<.[[<<<<..<<<<<.<<.<<<<<..<<<<<<<.<<<<..<<<<..>>>>..>>>>.>>>>>>>...<<<....>>>......>>>>>.>>..>>>>>...<.<.....>.>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<.........>>>>>....<<..[.(((.>>...>>>>>>>...<<<<<<<<......>>>>>>>>..<<<....>>>.>>)))]......<<<<<<.<<<...>>>>>.>>>>>>>>>..........>>>>..]]>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>..>>.......<<<<<.<<<<<<..<<<.<<<<<......>>>>>...>>>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..>>>.>>>.]]...<<<....<<<<.<<<<<<..................>>>>>><.<<<...<<<<...<<<<.<<<<.]]...>>>>.>>>>...>>>>.>>>.><<<<....<<<<<...........>>>>>....>>>>>>>>....>>>...<<<<<.<<<<.......>>>>....<<<<<<<<<<<<<....<<<<<..<<<..<<<...>>>.>>>..>>>>>...>>>>>>.>>>>>>>...>>>>>.. ...((((((((((.....(((..((((((((.(.(......((((((.[[.....)))....((((((..((.]].)).....))))))...))).....((((.....)))))....(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........((((((....)))))....).......((((((((((...((((.........))))[[(...).(((.....]])))...)))))))))).........)....(((((((........)))))))....(((((..[[[[[.)))))..)))......)..)))))).))...............((....))....)).).....)))))))))).(((((.....)))))[((((........))))((((((..(.((((.((((((((..(((..(((((.....)))))..)))...((....)).....)))))))).))))..((.(...((((.((.....(((((((((.(((((...(((((((....)))))))...)[))))..(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))).((((((....(((((....)))))((((((..(((((.(((((((.....(((....(.(((...(((....)))..))).)...)).).....)))))..)))))..))..)))).))..((.(((((((.....))))))).))....(((......)))...(((((((...(((.[[...(((((((.....(......((.(((((((((((...)))))))))))))..........]]..)...))))))))))...))))))).........))))))(.((((((((((......(.((((((....)))))).)...))))))))))..).....))))))((.....((.....((((((......)))))).(((.....((((..((..(((((((....))))))....[[(((.((...((..((((......))))..))....))...(((((........)))))]]((((((((((..(((....)))....(((.(((((...((((.((((..((((((((((((...{{..))))))((..((.....((((((((.....(((.....))).....))))))))....))..))((((((....))))))))))))...)))).))))(...)....))))))))...)))))))))).))).)))..((......)).)))).((((.....))))..)))....(......(((((((.((..(....(.......(((((....(.{..).....)))))((((((....))))))(...).......(((((((((.].((.........))...(((((((........))))))).}.(((.(((..(((((((...((.....((........)).....)).)))))..)))))(((((.........)))))........((..........((((((.....))))))..)..)....)))....)).))))))).)..))).)))))))...)..))....)).{..(((((.....]}.)))))..((.(((..(((.((......((((.((((((..(((((.((.(((((..(((((((.((....(((....)))....)).)))))))...(((....)))......))))).))..)))))..(((......[)).)((((((..........]))))))(.((...(((((((.(.(((((....(..).)))))...).(..[.[[[.)....)))))))...(((((((((....)))))))))..(((....))).))]]].].....((((((..((...]]]]].)).))))))....).....))))..)))))).......(..(.(..(((((...((.......))...)))))....))...)........((((.((((((..(((.(((((......)))))...))).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).))).))...(((....(((..((((((.......(....).....))))))(.(((...((((...((((.(((((}}..))))).))))...)))).))).)((((....((((.............))))....)))).)))....)))...(((((.((((.......))))..(.(((((((((((((....(((((..((....((...))...))..)))))...)))))).))))))))..))))).. Spraguea lophii ribosome; RNA 23S 7qca L70 119 2.79 RF00001 URS00026177A4_1358809 0003735 0005840 1358809 aguuacggccauaucuacugaaaaacaccggaucccguccgaucuccgaaguuaagccaauaagagccaugcgaguauuaaggugggcgacuacuugagaaagcguggugcuguaguuu <<<<<<<<<....<<<<.<<......<<<<<..............>>>..>>.....>>.>>.>><<<<<<<.....<<<<<..<<....>>.>>>>>....>>>>>>>>>>>>>>>>. ((.((((((....((((.((......((((((...(....)...))))..)).....)).)).))((((((......(((((..((....)).))))).....)))))))))))).)). Spraguea lophii ribosome; RNA 5S 7qca S60 1354 2.79 RF02542 URS000261779A_1358809 0003735 0005840 1358809 accagguugauucugccugacguggaugcuagucucauagauuuagccaugcauguguaagcgaagcgauuagugaagcggcggaaggcucaguaacgggcgaguauuuaaucucuagaaccggacaaccucaggaaacagaggggaaaacggaguaagagcauguguuagcaugugaugagaacaacagugcaggagaguaagaagccaucccaucaguuaguaaguaggguaagggccuauuuagacguagacggguacgggggauuaggguuugauuccggagagggagccugagagacggcuaccagguccaaggacagcagcaggcgcgaaaauuaccgaagccuccaagagggcgguagugaagagacgugaaaacaaguguguguaaaaaccacaugaguaacuggaggucaaggcuggugccagcauccgcgguaauaccagcuccaggagugucuaugaugauugcugcgauuaaaagguccguagucgaagaacaguacuuguuuguaauguggcuuaucgagagccgaauagaacgagaagaguucagaguaaggagcgaaggagggcuagauuauugagcagcgagaggugaaauuugaugaccugcuuaggaguaacagaggcgaaagcgcuagucaagaacgaauccgaugaucaaggacguaggcuggaggaucgaagacgauuagagaccguaguaguuccagcaguaaacgaugccuacgcuguugugguuaugagcacggcagaagagaaaucuaguagggcuuuggggagaguacgcgcgcaagcgauaaauuuaaaggaaauugacggaagaacaccacaaggaguggagugugcggcuuaauuugacucaacgcgggacagcuuaccauacccgauggccgugugagcguaguacgcgauaggucagagaguggugcauggccguuaacgacgaguggggugaccuuuggguuaaguccgcgaaguagugagaucccuaggauacgaaaguuaucgacagguguuaaaaacacaggaaggaaggggcaagaacaggucagugaugcccuuagaugguaugggcugcacgcgcacuacaguggucacagcagaaacaaauagaaguaaaugugaucgagagggaaugagcacuguaaugugcacaggaacgaggaauugcuaguaaucguuaucucauuaagaagcgaugaaugugucccuguucuuuguacacaccgcccgucguuaucgaagauggaaccaggugcgaacaagugaaagcgagugagugcaggguucuagaucugauacaagucguaacaaggcagcuguaggagaaccuguagcuggauca ..<<<<<.[.(((.>>>>>.<<<<<<<<<..<<<<<.<.......<<<.<<<..<<....<<...<<.....>>...>>.>>......<<.......<<<<.....<<...<<<<<.<..<<<.....<<<<.<....>.>>>>......>>>....<..<<<<<<....>>>>>>..>....<<....>>.>.>>>>>..>>...>>>.><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>..<<<<..>>>>....>>>>>>.........<<<....<<<<...>>>>..>>>...>..>>>>>..........<<<<<.........>>>>>......<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<...<<<<....<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>....>>>>.......<<<.<<......<<<<<<..<.<<<<<<<<...<<<......>>>......>>>>>>>>..>........<<....>>.>>>>>>.....>>..>>>...>>>...>>>>..<.<<<<<<<...<....<<<.........>>>....>>>>>>>>..>.......<<<.<<.<<<<<<<<.<<..>>.>>>>>>>>..<<..))>>..>>..>>>.>>>.<<<.......<<<....>>>.....>>>....))).]<<<<<.<<<<<<<..<<.<<.<<<..<<<<<<<<<<......<<........>>..........<<<<<<<...<<<<<......<<<<...>>>>....>>>>>..<<<.<<<..<<.<<<<<<....<<.<..<<<....>>>...<<......>>......>.>>....<<<<<.<..<<<....>>.>.>.....<<<<.....>>>>........>>>>>....>>>.>>>.....>>>>>>>>....>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....................>>>>>>>....<....<<.<<<<......>>>>.>>....>.....>>>.>>....<<<<<..<<.......>>.>>>>>......>>...>>>>>>>>>>.>>.......<<.<..<<<<<.<...<<<<<<..<<<<..<<..<<....>>..>>..>>>>..>>>>>>...>.>>>>>...>.>>.........<<<<<<<<<....>>>>>>>>>...... ..((((..[.[[[..)))).(((((((((..(((((.(((.....(((.(((..((....((...((.....))...)).))......(((.......(((...(.((...(((((.(..(((.....((((.(....).))))......)))....(..((((((....))))))..).....(....)..).)))))..)))..)))..(((....(((..(((.((((.......)))).))))))......)))..(((.((((....))))....)))))).((.(((..........))).))..(((....)))....)))))).).....(.(((...(((((...)))).))))).))..)))))..........(((((.........)))))......((((([[....(.((((.....((..]])).......))))))))))..)))))))))..........((([[...(.((((...(((...((((....(((((((......((((((.....))))))....)))))))....))))......((((.((......(((((((....(((((((...((........))......)))))))....).......((....)).)))))).....))..)))..))))...))))....((((((....(....(((.........)))....).))))))......{...(((.((.((((((((.(....).))))))))..((..]]))..))..))))))).(((.......(((....))).....)))....]]].](((((.(((((((..((..(.(((..((((((((((......((........))..........(((((((...(((((......((((...))))....)))))..(((.(((...(.((((((....((.(.((((....)))...((......))....).).)).....((((.(...((....))...)..(..((((.....)))).....)..)))).....))).))).....).))))))....)))))))...)).)))))))).(...(((((((.....................)))))))....(....((.((((......)))).))....)..)..))).).....((((((.((.......))))))))......))...)))))))))).))..(.(..((.(..(((((.(..(((((((..((((..((..((....))..))..))))..)))))))..).)))))...).))...)..)..(((((((((....)))))))))}..... Spraguea lophii ribosome; RNA SSU 7qep 1 2319 2.7 RF02540,RF02543 URS0002335900_284813 0003735 0005840 284813 ucucuguucacgggauugauuggcauuagcggcgaugaaggacgugcaggaggacgauaugcguuguuguugugacggugucugaauugugugcggugugcacggggaccccuuggacuuaagcauaucaguaaagggaggagaagaaaccaaaugggauugccugaguagcggcgagugaaauggcaugagccugugugguaacugcguggcggguuguguuuguggcagcagcggcgagugcgauugaauucggaugcggagagggcgaugugccuguaggcgcggcggcuuuuuuugugaguaguguugcuugguagugcagcgcgaaugcggugguggaugcaccgaaggcuaaauauggcugaugaccgauagcggauaaguagagugauugaagugugaaaaggaggaugaugagaaaugaaagugaauggagugaaugggggauguucccgcccgucuugaaacacggaccaaggagacgacggcaggauuguuuuccgagaggggaggaugcugcggucggacccgaaagauggugagcuauguguguguugauugaagggaugcgaaaguguucuggaggaucuaagccguucugacgugcaacucgauggcaugacaugugcauaggggcgaaagaccaaacgaaccaucugguagcugguucccucugaaaugucucucaggacagcggcgacggguguaagauguuguaaagcacuaaugcgcugcguuaaacuuugaagaugucuuuuaaguuguugccagugggcauacugugguaagcauggugugcgagaagggaugaaccuuuaagcgggcuaaggagucuuaugcaaggugaauccggcggccugauuuugacagccgaauugggcggcggagaaaauggaagggauugaauugcauuccgaugccugcgggggaguaucugaguaagggggcgguaucguucugcugaagguccugcgugagcggggguggaggggcgauaugugcagaucuugguagcaguaacaaggaaaugauuugcgcuggacgaggguucccuguggcaggggugaaucgacuguggauacggaggugcauugauaguuguguguauugcggcugggaggcgacuuggcugugacggaugggggcggcccuguccaggauagcagaacuggaugucugcugcggauuguuaugaugcgaagcagcgaugggcgagccuguuccgaugaaaaagaggcugcuuugucguaccuagaccgcaucugguguccacuguuugccgcggaaguguuuugugcaagggccguaagggaagucggcaagauugauguguaacuucgggagaaggauuggcucuagcgugcuagaacuguuuguuguggggaaucugacuguuuacuaaaaacauagcuuuguguguggacgcaaagugaauucugcccagugcacuuuuaguuacggccuguugggcuaagcgaguguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucauguaauuagugacgcgcaugaauggagcaacgagauucccacugucccuacggccugucuugugaaccuacagccaagggaacgggcuugggcugaucagcggggaaagaagacccuguugagcuugacucuagcaugugugaagugcugggugcccagugcuuuguggauggauguggggaguuuggcuggggcggcacgacugcuaaagacuaacgcagacguccuaaggcgggcucagcggggaaggaaaccacgcguggagcacaagggcacaagccugcuugagacuguuccuauugcgggacuguuugggggaaacccuggccuagagaucccauguccuauugugcgugggacaugggugacagaaaaguuaccacagggauaacuggcuuguagcagccgagcgaccauagcgacgcugcuuuuugauucuucgaugucggcucuuccuaucaucgcgaagcagagauugcgaaguguuggauuguucacccaccaacagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacuguguggacugugcagcagaucuugauaguacgagaggaacucuugauugcgaccucugguggagcggcgugccugcuggcugcugcggagcuacgucgggaguauaauggcugaaggccucuaagccugaagaccgacugcgcgguguguguggcggaagacgaccgcugugugugcaagcugugcggauggaggaggauuccgacauuuugaggcugugcauu [<<<<<<<<<<.......[..<<<<<<<<<..<......<<<<<<........>>>.....<<<<<......>>>>>...>>>.....<<<<<<...>>>>>>>....<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<......<<.....>>.....>>>>...<<<..........<<<<...>>>>...........<<<.<<.<<<.<.....<<<......>>>..((......<<<.....))>>>...>.>>>.>>.>>>.............<<<<<<<........>>>>>>>.....<<<<<..<.<<<>>>>>..>>>........>>>>>>>.>>...............<<....>>....]............................>>>>>>>>>>....<<<<.......>>>>.<<<<........>>>><<<<<<....<<<<.<<<<.<<<.....<<....>>....>>>.>>>>.>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<....<<<<<<<<<...<<<...<<<<<<<.>>>>>>>..>.>>...>>>>>>>..>>...>>>>>>>.>>..<<<<<<<<<<.....>>>>>>>>>>...<<<<......>>>>...<<<<<<...<<<.(....<<<<<......<<<<...<<<<<<<............>>>>>>>..>>>>...........).......>>>>>.>>>...>>>>>>..<<<....>>>.....>>>>>><.<<<<<<<<<<......<.<<<<<<....>>>>>>.>...>>>>>>>>>>..>.....>>>>>><<.....<<<<.<<<....>>><<<.<<<<<<.<<...<<<<<<.>>>>>>....((<<<<<<......>>....<<<<........>>>>.))...<<<<<...<<<....>>>.........<<<<<<<....<<<<<<<<<<<...((((...>>>>>>><.<<<<<<...<<.....>>......>>>>>>>.>>>>...>>>>>>>.............>>>>>...>>>>..>>....<<......>>>>>>>><<<<.....>>>>...>>>.........<<<<<<<<.<<.........<.....<<<.<....<<..>>.....>.>>><<.<<<<<<..>>>>>>.>>..........<<<<<<<<<..<<<.........>>>..<<<<<<<........>>>>>>>...<<..<<<..<<<<<<<<...<<<..<<<<<...>>>>>.>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>>...>>>>....>>....<<<<<........>>>>>....].<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<.<<..<<<<<<<<<<..>>>>>>>>>>......>>.>>>>..>>>>>...<<<.....>>>..<.<<<<...........>>>>.>..<<...<<<<<<<...<<<.<<.......>>.>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<......>>>>>.>>>..<<<....>>>.>>))).......<<<<<<<<<..>>>.>..>>>>>>>>>..........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>..>>.......<<<<<.<<<<<<..<<<<<<<<........>>>>>..>>>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>.....<<<<<<<<<..<<<<..<<...............>>..>>>>.<<<<....<<<...<<<<<<.<<.)))).>>>>>>>>...>>>..>>>>...<<.<...<<<<...........>>>>....>>>...>>>>>>>>>......<<<<<.......>>>>>....<<<<<<<<<.....<<<<..<<<....>>>..>>>>....>>>>.>>>>>. (((((((((((.....(.(..((((((((((.(......((((((.......[)))...].((((((....))))))...))).....((((((...)))))))....(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((........(((((...))))....)......(((.((.(((.(...(.(((......))).)[[(...).(((.....]])))...).))).)).)))........)....(((((((........))))))).....(((((..[.[[[)))))..)))......).))))))).))...............((....))....)......................).....)))))))))).....(((.......))).[((((........))))((((((....((((.((((.(((.....((....))....))).)))).))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((........)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(((((....)))))((((((((...(.(((((((((...(((...(((.((...)).)))..)).)...)))))))..)))...)))))).))..((((((((((.....))))))))))....(((......)))....((((((...(((.[[...(((((......((((.(.(((((((.....{.()...)))))))).))))..........]].......))))).)))...))))))..(((....))).....))))))(.((((((((((......(.((((((....)))))).)...))))))))))..).....))))))((.....((((.(((....)))((((.((((..((...((((((.))))))....[[((((.(......)....(((((........)))))]](..(((((...(.(....).).....(...(((((((....(((((((((((....{{{...)))))))((.(((((...((.....))......))))))).))))...)))))))(...)....)...)))))..)))))..))....((......)).)))).((((..[.[))))..)))).........((((((((.((..(....(.......(((.(....(.{..).....).)))((.((((((..)))))).)).......]].(((((((((.].((.........))...(((((((........))))))).}.(((.(((..((((((((...((...((((((.))))))..))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).))))))))...))))....)).{..(((((.....]}.)))))....).(((..(((.((......((((.((((((..(((((.((((.(((.((((((((((..)))))))))).....))).))))..)))))..(((......[)).)(.((((..........])))).)([((...(((((((.(.(((.((.......)).)))...).((][.[[[))....)))))))...(((.(((((......))))).)))..(((....))).))]]].].....((((((((((.]]].].))))))))))....).....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..((((((((........)))))..))).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))....))..))).))).....(((((((((..((((..((.....(....)....))..)))).((((...((((...(((((..(((}}}.))).)))))...)))).)))).(.((.....(((.....}.......))).....)))..)))))))))......(((((.......)))))....(((((((((....(((((..(((....)))..)))))...)))).))))). Cryo-EM structure of the ribosome from Encephalitozoon cuniculi; 5.8S-23S ribosomal RNA 7qep 2 119 2.7 RF00001 URS00006313BF_284813 0003735 0005840 284813 aguugcggccauauccacggaaaagcaccggaacucgucagaucuccgaaguuaagccugugcgagccuggguaguacugagaagggagaccacucgggaauaccgggugcugcaacuu <<<<<<<<.....<<<<<<<......<<<<<..............>>>..>>.....>>>>>.>><<<<<<......<<<<<..<<....>>.>>>>>.....>>>>>>.>>>>>>>>. (((((((((....(((((.(......((((((...(....)...))))..)).....).))).))((((((......(((((..((....)).))))).....))))))))))))))). Cryo-EM structure of the ribosome from Encephalitozoon cuniculi; 5S ribosomal RNA 7qep 3 1295 2.7 RF02542,RF01960,RF01959,RF00177 URS0000489243_284813 0003735 0005840 284813 aucagguugauucugccugacguggaugcuauucucuggggcuaagccaugcaugcuugugaacucuuugugggggauuagcggacggcucagugauagcacgaugauuuguuugcgggaugagcaguagcugcgggaaacugcagauaguggucugccccuguggggguuggcaaguaaguugugggccuaucagcugguaguuaggguaauggccuaacuaggcgcagacgggauacgggggaucaggguuugguuccggagagggagccugagagauggcuacuacguccaaggauggcagcaggcgcgaaacuugccuaauccuuuggggaggcgguuaugagaagugaugugugugcgagugcaaaggggucgcaugugauuggagggcaagucgggugccagcagccgcgguaauaccugcuccaauagugucuaugguggaugcugcaguuaaaauguccguagucuguguaugucuuugugugugauguuugugguuguguguggauguagugaguguguggcagaggacgaggggcacuggauaguugggcgagaggugaaaugcgaagacccugacuggacgagcggaagcgaaggcugugcucuuggacuaauguugcgaugaaggacgaaggcuagaggaucgaaaucgauuagauaccguuuuaguucuagcaguaaacgaugccgacuggacgggacaguguguguuguccaugagaaaucuugaguaugcggguucuggggauaguaugcucgcaagagugaaacuugaagagauugacggaaggacaccacaaggaguggagugugcggcuuaauuugacucaacgcggggcaacuuaccggcucugaaggaugccugugagugcauggcaugaggcaugcggcgguggugcauggccguuuuaaauggauggcgugagcuuugucuuaaguugcguaagaugugagacccuuugacgguguucuacggagcaaggaggggauggaagagaacagguccguuaugcccugagaugaggcgggcugcacgcgcacuacgauagauggcgcuucugccugcugugagggaugaagcuguguaaggggcuucugaacguggaauuccuaguaauagcggcugacgaagcugcuuugaaugugucccuguccuuuguacacaccgcccgucgcuaucuaagaugacgcacuggacgaagaucggaaggucugaguccugaguguuagauaagauauaagucguaacauggcugcuguuggagaaccagcagcaggaucaguau ..<<<<..[.((((.>>>>.<<<<<<<<<..<<<<<.<.......<<<.<<<..<<<......<<<.....>>>.....>>>......<<.........<<<<<<..<<..<<<<<.....<<.<<...<<<<<<......>>>>>.>..>>.>>.<<<<<....>>>>>..>>>>>.>>>>>>>>..<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>...<<<<<<<<....>>>>...>>>>.>>.<<.<<<..........>>>.>>.<<<<....>>>>...>>>>>>.........<<<....<<....>>..>>>...>..>>>>>.........<<<<<<.<.......>.>>>>>>....<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<....<<<<<<<....<<<<<<<.......>>>>>>>..>>>>>>>...........<<<.<<..<<.<<<<<<<<.<.<<<<<<<<...<..........>......>>>>>>>>..>>.......<<....>>.>>>>>>>>>..>>..>>>...>>>...>>>>....<<<<<<<...<..<<.<<.<.....>.>>.>>..>>>>>>>>..........<<<.<<.<<<<<<.<<<...>>>.>>>>>>..<<..))>>....>>.....>>>.>>>.<<.......<<<<....>>>>.....>>..)))).]<<<<<.<<<<<<<..<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<.<<<......<<<<<.....<<<.....>>>..>>>>>....<<<.<<<..<<.<<<<<<....<<<...<<<....>>>..<<........>>......>>>.....<<........<<<<<....>>>>>..........>>.....>>>.>>>.....>>>>>>>>....>>>.>>>...>>.>>>>>>>>.....<<..<<<......>>>..>>....<....<<<<<<........>>>>>>....>.....>>>>>>....<.<<<<<<.......>>>>>>.>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<<.<...<<<<<.<.<<<<..<<<<<....>>>>>..>>>>.>.>>>>>...>.>>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>.......... ..((((..[..[[..)))).(((((((((..(((((.(((.....(((.(((..(((......((((..).))).....)))......(((........((((((..((...((((...(.((.((....((((((....))))))....)).)))(((((....)))))..))))..))))))))..(((....(((..((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).((((....))))...)))))).).....(.(((...(((....)).))))).))..))))).........((((((.(.......).))))))....((((([[....(.((((.....((..]])).......))))))))))..)))))))))...[......((([[...(.((((...(((....(((((((....(((((((.......)))))))..)))))))..........((((.((..((.(((((((((...(((((((...(..........)......)))))))...)).......((....)).)))))))))..))..)))..))))...))))....((((((....(...(.((.........)).)...).))))))......{...(((.((.((((((.(((...))).))))))..((..]]))....))...].))))))).((.......((((....)))).....))...]]..](((((.(((((((..((..(((((..((((((((((......((........))..........(((.(((....(.(((((.....((((...))))..))))).)..(((.(((...(.((((((....(((..((((....)))..((........))...)..))).....((.....(..(((((....))))).....)....)).....))).))).....).))))))....))).)))...)).)))))))).(...((..(((......)))..))....(....((((((........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..(((((.(..((((((.(.((((..(((((....)))))..)))).).))))))..).)))))...).))...)..)..(((((((((....)))))))))}......... Cryo-EM structure of the ribosome from Encephalitozoon cuniculi; 18S ribosomal RNA 7qg8 A 73 3.97 RF00005 URS00023358F7_83333 35264790 0030533 0006412 83333 gcgcggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgcgca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>. (((((((..((((.....[..)))).(((((.......))))).....(((((..]....)))))))))))). Structure of the collided E. coli disome - VemP-stalled 70S ribosome; A-site tRNA 7qg8 M 75 3.97 RF00005 URS00004FF598_83333 35264790 0030533 0006412 83333 ugggguaucgccaagcgguaaggcaccggauucugauuccggcauuccgagguucgaauccucguaccccagcca <<<<<<<..<<<.........>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..(((.....[...))).(((((.......))))).....(((((..]....)))))))))))).... Structure of the collided E. coli disome - VemP-stalled 70S ribosome; P-site tRNA 7qg8 O 118 3.97 RF00001 URS0000049E57_83333 35264790 0003735 0005840 83333 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))). Structure of the collided E. coli disome - VemP-stalled 70S ribosome; 5S rRNA 7qg8 N 2897 3.97 RF02540,RF02541 URS000080E25C_83333 35264790 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>...[.....<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))....].]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<.>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<<..<<...........>>..>>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<<.<<....>>..>>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<<<<<..<<.......<<<<<<<<....>>>>>>>>....>>............>>>>>...>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>.(<<...<<<<<<<...<<<<<<.......>>>>>>.....<<)..(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((..((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))))))..)))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((((((.)))).))...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..((...........))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((.((....)).))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.(...............(..(............((...(......)...))...................)..)......).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Structure of the collided E. coli disome - VemP-stalled 70S ribosome; 23S rRNA 7qg8 0 1532 3.97 RF00177,RF01959,RF01960 URS000080DDC0_83333 35264790 0003735 0005840 83333 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggauc .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<<....>>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>..<<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>>.<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<.<<....>>>.>>....<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((((....))))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....(((.((((.......)))).))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((.(......)).))....((....))..))))).))).((.((....((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..((.......))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...))..))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Structure of the collided E. coli disome - VemP-stalled 70S ribosome; 16S rRNA 7qgg S2 1714 2.86 RF01960,RF02542,RF01959,RF00177 URS000261771A_10116 36038000 0003735 0005840 10116 uaccugguugauccugccaguagcaunugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuauggunccuunggucgcucgcuccucuccuacuuggauaacugugguanuucuagngcuaauanaugccgacgggcgcugaccccccucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgcccuccguggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcnaauuacccacucccgacccgggganguagugangaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugagucnacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauancguauauuaaaguugcugcaguunaaaagcucguaguungaucuugggagcgggcguccccgcccucucggccggggcccgaagcguuuacuuugaaaaaanuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagancgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacncaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggcnguucuuaguugguggagcgauuugucugguuaauucngauaacgaacgagacucuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauunagucccugcccuuuguacacaccgnccgucgnuacuaccgauuggaugguuuagugaggcccucggaucggcccggagcgcugagaagacggucgaacuugncuaucuagaggaaguaaaagucgnancaagguuucnguaggugnnccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<..<.....<<<.<....<<....<<<<...................<<.....<<..<<.....>>..>>......>>.........<<<<......................>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<<......>>>>>>>>..>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>>>>.<<.<<<..........>>>.>>...<<....>>.....>>>>>>.........<<<...<<<<.....>>>.>>>>..>...>>.>.....<<.<<<<<..<<<....>>>...>>>>>.>.>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<.......................<<................>>...<<<<<<.<.......<<...<.......>.<<<<.......>>>>...>>......>.>>>..>>>........<.<<.<<<<<<<...............>>>>>>>.>>.>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<.......>>>>.>>>>.....>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<.<<.<<.<<<..<<<<.<<...<<<<<.......>>>>>...>>.>>>>..>>>.>>>.>>>....>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..((....(((.....((.........[...((.....((..((.....))..))......))......)).((((......................))))((..(((((...(......)..)))))......)).(]((((.((((......)))))))))...)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).)......(...(.(..(((....)))...).)...)......(.((..(...........)..))......)..((((([[....(.((((.....((..]])).......))))))))))..)))))).)))..[......(.([[...(.(.((....((..(.......................((................))...((.(((.(........(..((.......)).((.(......)))....).......).)))...))........(.((.(.((.((...............)).)).).)).)....)....(((..(...(...((((..((..((((((((...((........))......))))))))..)).......((....))...))))..)...)...))..)))....)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.((.(......).)))))))).)..)))...((..]]))...))...].))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.((..........)).))....).)))))...((.(((...(.(((((..(..(((.(((((....)))..(.((......)))...)).)))....(((...(...((((..((((((((((((.......)))).)))).....))))..))))..).....(((((.....)))))........))).)...)).))).....).))))).....).)))))...)).)))).))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((........(....(((..((((.((...((((.........))))...)).))))..)))...)........)).))))...).))...)..)..(((((((((....)))))))))}........ Neuronal RNA granules are ribosome complexes stalled at the pre-translocation state; RNA (1872-MER) 7qgg D 157 2.86 RF00002,RF02540 URS0000005270_10116 36038000 0003735 0005840 10116 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>.............>>>..)...>>>....<<....>><<<<<<<<<.....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))(((((((((.....)))))))))..................... Neuronal RNA granules are ribosome complexes stalled at the pre-translocation state; RNA (157-MER) 7qgg E 119 2.86 RF00001 URS00000F9D45_10116 36038000 0003735 0005840 10116 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>. (((((((((....((((((((.....((..((...(....)...))....))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))). Neuronal RNA granules are ribosome complexes stalled at the pre-translocation state; RNA (121-MER) 7qgg t 3679 2.86 RF02543 URS0002617736_10116 36038000 0003735 0005840 10116 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccgcgcgcggcgcgggaaauguggcguacggaagacccacuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgcgcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagccaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcgcgcguccggccgugccgguggccggcggaucuuucccgcucccggugucggcgggggaccgccccccggaucggcgaccggccgccgccgggcgcacuuccaggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucggggccccgaguguuacagccccccggcagcagcgcucgccgaaucccggggccgagggagccggauacccgucgccgcgcucuccccccggcgggggccgggccgccccucccacggcgcgaccgcucucccagggggcggggcggacuguccccagugcgccccgggcgucgucgcgccgucgggcccgggcgcgcucucccuccccuucucggggugggggggagcgagagcgcacggggucggcggcgaugucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacgcgugcgcgagucaggggcucguccgaaagccgccguggcgcaaugaaggugaagggccccguucccgggggccgaggugggaucccgaggccucuccaguccgccgaggggcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcguacgcguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcaacgcggucgacaacccgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcgucggaacgggacgggagcggccgcucgggccccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagugccguuccgaagggacgggcgauggccuccguugcccucagccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcaguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcuggcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacaugagagguguagaauaagugggaggcccgggccgccggugaaauaccacuacucucaucguuuuuucacugacccggugaggcgggggggcgagccccgaggggcucucgcuucuggcgccaagcgcccgucgggcgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgaaggagccucgguuggccccggauagccggcucccgggguccggugcggagagccauucgucccgggaaacggggugcggccggaaagggggccgcccucucgcccgucacgcuuaacgcacguucguguggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..[[[..<...<...<.<<<<<..........>>>>>.>.....>..>...<.<<..<<.....<..<<<<.......<<<<........<.<........>.>..................................>>>>..>>>>..>....>>..>>.>.......<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<.<.....<..<<.<..<.<....<<.<..<..<.........<.<..<<<..<<..<<<<<.<<<..<<<<<<<.....>..>>>>>>>>>>>>>>>>.>>>.>.>........>..>..>.>>....>.>..>.>>..>..<<<<<<<..<<<<<<<<<<.<<<....<..<.......<<.<......<<<<<<<..>>>>>>>.........>>>......>......>.>>>...>>>>>>>>>>..........................<..<<<<<....>>>>>..<.<<.<.<<<.<<...<....<..<<<<...<<...>>..<<<<<<.<<<<....>>>>.>>>>>>.>>>>...>....>....>>....>>>>>>..>.......<<<<<<<......>>>>>>>.......>..........>>.>>>>>...>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<.<<<<<....>>>>>.>>..<<<<<..<<<...<....((((..[[..>...>>>...>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<..........<<..>>.....<<<.<<<<<<<<<...<<<....<<<..<.<<<..<<<<<<.........>>>>>>>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>>>>>>.>>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<.....................>>........<........>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<...........]]...))))............................>.>>>>>>....>>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<<<<<...>>>>>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<..<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<<<<<<<<<<<<..{{{..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>.>.>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<...............<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<.>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<<.<<<<<<<<<<<<<<<<<..........<<<.<..<<<<..>>>>............>.>>>.>>>>>>>.>>>>>>>>>>...<<<<<.....<<<<....<<<...<.....>..>>..>.............<<<<<<<<...>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>>.<<<....>>>.>>))).......((((((..(((..>>>>>>.)))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]].....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<}}}.>>>>>..>>.>>...>>>>...>>>><<<<....<<<<<...........>>>>>....>>>>.>>>...>.>>>>>>......<<<<<...<...<.<.<<................<.<<<..>>>.>..................<<<..<<<<.........<<<<<..........>>>>>.......>>>>..>>>............>>..>.>...>..>>>>>.<<<<<.<.............>.....<.<<<<<<<.<<.....<<<<.<..<<<<<......>>>>>..>>>>>....>>....>>>>.>>>.>...>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.....(...(.(((((..........))))).).....)......(.(...((.(...(..(((........((((..........(........).........(...)...(........).........))))...)))..)...)))...).)..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.......(..((.(....(....((.(..(..((........(....(..(.((..(((((.(((..(((((((.(.).)..))))))))))))))))).)....).......))..)..).))....)....).))..)...(((((((.((((.(((((.(((....(..(.(.....((.........((((((()))))))...........)).....))......).)))...))))).)))).............................(((((....))))).....(.(.(((.((...(....(..((.....((...))..((((((.((((....)))).))))))...))...)....)....))....))))).........(.(((.((........)).))).)...............))).)))).....)))...)))))))).[((((........))))((((((....(((((((((((((..(((..((((..........)))..)..)))...((....))...((.(((((....))))).))..(((((...((...(.(..[[.....[.))...))....))))).(((((((((.((((......))))))))))).))....)))))))))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((..........((..)).....(((.((((((((....(((....(((..(.(((..(((((..(.....)..)))))))).)..)))..)).)....))))))...(((((((((.(......))))))))))....))))))))))))..))..((((.((.((.....)).)).))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.(.((((((((.......(((((.((.....................))....(...(........).).)))))...)))))))).))))..........]]].)....))))))))))...)))))))((((((.(...........]......]]..............(...).........).))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((..(((((((....(.....)..))))))....[[(((.((...((..(.(((....))).....)....((.((((.((((...)))).))))))......))....))...(.(((........))).)]]((((....(((((...(((((((....)))))))..((((....)))...(...((((.....(((((((((((((((((((((((..{{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....(((((((.......))))))))))).).))))))))))))(...)......))))...)).........)).))).)))).))).))).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((.)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.....((.....((((....)))).....))..))))..)))))(((((.........)))))........((.(......).(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.(((((((((.((((((((((((.((((..........(((.(..((((()))))............).))).)))).)).))))))))))...(((((.....((((..[.((.....(...)....).]).............(((((((.....)))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a.))..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}}.)))))..)).))...))))...)))).((((...((((.............))))...))))..)))...).))))))......(((((.......(.(.(.................(.(.(..).).)..................(((..((((.....(.(.((((.(.........)))))).)....))))..))).............)..).)......))))).(((((.(..(.......)..).....(.(((((((.((.....((((.(..(((((......)))))..)))))....))....)))).))).)...))))).. Neuronal RNA granules are ribosome complexes stalled at the pre-translocation state; RNA (4803-MER) 7qgg u 76 2.86 RF00005 URS0000EEAD11_10116 36038000 0030533 0006412 10116 gcccggauagcucagucgguagagcaggggauuccguauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... .(.((((..((.(........).))..((((.......))))......((.((.......)).)))))).)..... Neuronal RNA granules are ribosome complexes stalled at the pre-translocation state; RNA (76-MER) 7qgg v 76 2.86 RF00005 URS0000EEAD31_10116 36038000 0030533 0006412 10116 ugcccgguagccccgaagguagagcaggggauuccgaauccccguguccuugguucgauuccgaguccgggcacca .<<<.....<<............>>.<<<<<<.....>>>>>>......<<<<.......>>.>>...>>.>.... ..((.....((.(........).)).(((((.......))))).......(((.(..)..)).)....))...... Neuronal RNA granules are ribosome complexes stalled at the pre-translocation state; RNA (76-MER) 7qgg w 20 2.86 URS0002617730_10116 36038000 10116 ucaucuacggcgguagaucu .................... .................... Neuronal RNA granules are ribosome complexes stalled at the pre-translocation state; RNA (5'-D(P*()P*()P*()P*())-R(P*UP*UP*AP*CP*GP*GP*CP*GP*GP*UP*()P*()P*()P*()P*()P*())-3') 7qgh O 118 4.48 RF00001 URS0000049E57_83333 35264790 0003735 0005840 83333 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))). Structure of the E. coli disome - collided 70S ribosome; 5S rRNA 7qgh N 2897 4.48 RF02540,RF02541 URS000080E25C_83333 35264790 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>...[.....<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))....].]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<.>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<<..<<...........>>..>>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<<.<<....>>..>>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<<<<<..<<.......<<<<<<<<....>>>>>>>>....>>............>>>>>...>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>.(<<...<<<<<<<...<<<<<<.......>>>>>>.....<<)..(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((..((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))))))..)))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((((((.)))).))...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..((...........))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((.((....)).))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.(...............(..(............((...(......)...))...................)..)......).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Structure of the E. coli disome - collided 70S ribosome; 23S rRNA 7qgh M 75 4.48 RF00005 URS00004FF598_83333 35264790 0030533 0006412 83333 ugggguaucgccaagcgguaaggcaccggauucugauuccggcauuccgagguucgaauccucguaccccagcca <<<<<<<..<<<.........>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..(((.....[...))).(((((.......))))).....(((((..]....)))))))))))).... Structure of the E. coli disome - collided 70S ribosome; P-site tRNA 7qgh 0 1539 4.48 RF00177,RF01959,RF01960 URS000080DDC0_83333 35264790 0003735 0005840 83333 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<<....>>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>..<<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>>.<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<.<<....>>>.>>....<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((((....))))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....(((.((((.......)))).))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((.(......)).))....((....))..))))).))).((.((....((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..((.......))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...))..))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Structure of the E. coli disome - collided 70S ribosome; 16S rRNA 7qgh u 73 4.48 RF00005 URS00023358F7_83333 35264790 0030533 0006412 83333 gcgcggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgcgca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>. (((((((..((((.....[..)))).(((((.......))))).....(((((..]....)))))))))))). Structure of the E. coli disome - collided 70S ribosome; A-site tRNA 7qgn A 73 3.37 RF00005 URS00023358F7_562 35264790 0030533 0006412 562 gcgcggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgcgca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>. (((((((..((((.....[..)))).(((((.......))))).....(((((..]....)))))))))))). Structure of the SmrB-bound E. coli disome - stalled 70S ribosome; A-site tRNA 7qgn M 75 3.37 RF00005 URS00004FF598_562 35264790 0030533 0006412 562 ugggguaucgccaagcgguaaggcaccggauucugauuccggcauuccgagguucgaauccucguaccccagcca <<<<<<<..<<<.........>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..(((.....[...))).(((((.......))))).....(((((..]....)))))))))))).... Structure of the SmrB-bound E. coli disome - stalled 70S ribosome; P-site tRNA 7qgn O 118 3.37 RF00001 URS0000049E57_562 35264790 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))). Structure of the SmrB-bound E. coli disome - stalled 70S ribosome; 5S rRNA 7qgn N 2897 3.37 RF02540,RF02541 URS000080E25C_562 35264790 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>...[.....<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))....].]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<.>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<<..<<...........>>..>>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<<.<<....>>..>>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<<<<<..<<.......<<<<<<<<....>>>>>>>>....>>............>>>>>...>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>.(<<...<<<<<<<...<<<<<<.......>>>>>>.....<<)..(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((..((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))))))..)))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((((((.)))).))...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..((...........))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((.((....)).))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.(...............(..(............((...(......)...))...................)..)......).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Structure of the SmrB-bound E. coli disome - stalled 70S ribosome; 23S rRNA 7qgn 0 1532 3.37 RF00177,RF01959,RF01960 URS000080DDC0_562 35264790 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggauc .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<<....>>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>..<<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>>.<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<.<<....>>>.>>....<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((((....))))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....(((.((((.......)))).))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((.(......)).))....((....))..))))).))).((.((....((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..((.......))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...))..))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Structure of the SmrB-bound E. coli disome - stalled 70S ribosome; 16S rRNA 7qgr O 118 5.7 RF00001 URS0000049E57_562 35264790 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))). Structure of the SmrB-bound E. coli disome - collided 70S ribosome; 5S rRNA 7qgr N 2897 5.7 RF02540,RF02541 URS000080E25C_562 35264790 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>...[.....<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))....].]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<.>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<<..<<...........>>..>>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<<.<<....>>..>>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<<<<<..<<.......<<<<<<<<....>>>>>>>>....>>............>>>>>...>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>.(<<...<<<<<<<...<<<<<<.......>>>>>>.....<<)..(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((..((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))))))..)))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((((((.)))).))...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..((...........))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((.((....)).))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.(...............(..(............((...(......)...))...................)..)......).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Structure of the SmrB-bound E. coli disome - collided 70S ribosome; 23S rRNA 7qgr M 75 5.7 RF00005 URS00004FF598_562 35264790 0030533 0006412 562 ugggguaucgccaagcgguaaggcaccggauucugauuccggcauuccgagguucgaauccucguaccccagcca <<<<<<<..<<<.........>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..(((.....[...))).(((((.......))))).....(((((..]....)))))))))))).... Structure of the SmrB-bound E. coli disome - collided 70S ribosome; P-site tRNA 7qgr x 44 5.7 35264790 663 agaccaaugccauguacgucgcacucaauagucaguuuucugca ............................................ ............................................ Structure of the SmrB-bound E. coli disome - collided 70S ribosome; mRNA 7qgr 0 1539 5.7 RF00177,RF01959,RF01960 URS000080DDC0_562 35264790 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<<....>>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>..<<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>>.<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<.<<....>>>.>>....<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((((....))))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....(((.((((.......)))).))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((.(......)).))....((....))..))))).))).((.((....((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..((.......))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...))..))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Structure of the SmrB-bound E. coli disome - collided 70S ribosome; 16S rRNA 7qgr u 73 5.7 RF00005 URS00023358F7_562 35264790 0030533 0006412 562 gcgcggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgcgca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>. (((((((..((((.....[..)))).(((((.......))))).....(((((..]....)))))))))))). Structure of the SmrB-bound E. coli disome - collided 70S ribosome; A-site tRNA 7qgu A 2923 4.75 RF02540,RF02541,RF00002 URS000081169B_1423 35264790 0003735 0005840 1423 uuaaguuagaaagggcgcacgguggaugccuuggcacuaggagccgaugaaggacgggacgaacaccgauaugcuucggggagcuguaagcaagcuuugauccggagauuuccgaauggggaaacccaccacucguaauggagugguauccauaucugaauucauaggauaugagaaggcagacccggggaacugaaacaucuaaguacccggaggaagagaaagcaaaugcgauucccugaguagcggcgagcgaaacgggaucagcccaaaccaagaggcuugccucuugggguuguaggacacucuguacggaguuacaaaggaacgagguagaugaagaggucuggaaaggcccgccauaggagguaacagcccuguagucaaaacuucguucucuccugaguggauccugaguacggcggaacacgugaaauuccgucggaauccgggaggaccaucucccaaggcuaaauacucccuagugaccgauagugaaccaguaccgugagggaaaggugaaaagcaccccggaaggggagugaaagagauccugaaaccgugugccuacaaguagucagagcccguuaacgggugauggcgugccuuuuguagaaugaaccggcgaguuacgaucucgugcaagguuaagcagaagaugcggagccgcagcgaaagcgagucugaauagggcgcaugaguacguggucguagacccgaaaccaggugaucuacccauguccagggugaaguucagguaacacugaauggaggcccgaacccacgcacguugaaaagugcggggaugagguguggguaggggugaaaugccaaucgaaccuggagauagcugguucucuccgaaauagcuuuagggcuagccucaagguaagagucuuggagguagagcacugauuggacuaggggccccuaccggguuaccgaauucagucaaacuccgaaugccaaugacuuauccuugggagucagacugcgagugauaagauccguagucgaaagggaaacagcccagaccgccagcuaaggucccaaaguauacguuaaguggaaaaggauguggaguugcuuagacaaccaggauguuggcuuagaagcagccaccauuuaaagagugcguaauagcucacuggucgagugacucugcgccgaaaauguaccggggcuaaacguaucaccgaagcugcggacuguucuucgaacagugguaggagagcguucuaagggcugugaagccagaccggaaggacugguggagcgcuuagaagugagaaugccgguaugaguagcgaaagaggggugagaauccccuccaccgaaugccuaagguuuccugaggaaggcucguccgcucaggguuagucgggaccuaagccgaggccgaaaggcguaggcgauggacaacagguugauauuccuguaccaccuccucaccauuugagcaauggggggacgcaggaggauaggguaagcgcgguauuggauauccgcguccaagcaguuaggcugggaaauaggcaaauccguuucccauaagccugagcugugauggcgagcgaaauauaguagcgaaguuccugauuccacacugccaagaaaagccucuagcgaggugagaggugcccguaccgcaaaccgacacagguaggcgaggagagaauccuaaggugaucgagagaacucucguuaaggaacucggcaaaaugaccccguaacuucgggagaaggggugcucuguuagggugcaagcccgagagagccgcagugaauaggcccaggcgacuguuuagcaaaaacacaggucucugcgaagccguaaggcgaaguauaggggcugacgccugcccggugcuggaagguuaagaggagcgcuuagcguaagcgaaggugcgaauugaagccccaguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgacccgcacgaaaggcgcaacgaucugggcacugucucaacgagagacucggugaaauuauaguaccugugaagaugcagguuacccgcgacaggacggaaagaccccguggagcuuuacugcagccugauauugaauguugguacagcuuguacaggauagguaggagccuuggaaaccggagcgccagcuucgguggaggcaucggugggauacuacccuggcuguauugaccuucuaacccgccgcccuuaucgggcggggagacagugucaggugggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguucccucagaaugguuggaaaucauucgcagaguguaaaggcacaagggagcuugacugcgagaccuacaagucgagcagggacgaaagucgggcuuagugauccggugguuccgcauggaagggccaucgcucaacggauaaaagcuaccccggggauaacaggcuuaucucccccaagaguccacaucgacggggagguuuggcaccucgaugucggcucaucgcauccuggggcuguagucggucccaaggguugggcuguucgcccauuaaagcgguacgcgagcuggguucagaacgucgugagacaguucggucccuauccgucgcgggcgcaggaaauuugagaggagcuguccuuaguacgagaggaccgggauggacgcaccgcugguguaccaguuguucugccaagggcaucgcuggguagcuaugugcggacgggauaagugcugaaagcaucuaagcaugaagccccccucaagaugagauuucccauuccgcaaggaaguaagaucccugaaagaugaucagguugauaggucugagguggaaguguggcgacacauggagcugacagauacuaaucgaucgaggacuuaac <<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<.....((.>>>.....<<<<<<<..<<<)).....>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<<<<<<<<.........>>>>>>>.>>.>>....<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<......<<.....>>.....>>>>...(((....<<<<<<<<<..>>>>>>>>>......<<<<<<<<<.....<<<<.......<<<<<<<<<<.<<<.....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>.>>>>>..>>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<......>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<.<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>......>>>>>.>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>...>.>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<...<<<<<<<<<.....<<<...<<<<<<<<...<<<<<<<.....>>>>>.>>...>>>>>>>>..>>.>.....>>>>.>>>>>..>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<.........>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<...>>>>>>>....>>>>>>..<<<<<<<.<<......<<<<<.<<....>>.>>>>>...>>.>>>>>>>........>>>>>><......<<....<<<<<<.......>>>>>><<<<....<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<.<<<<<<......<<...<<<<....<<<<..<<<..<<<.<.<<<.<.....{....>.>>>.<<...<<<<<.<<<<.<<<<<<<.<<.....>>>>>>>>>....>>>>..>>>>>...>><..<<...........>>...>>.>>>...>>>...>>>>.........>>>>..>>..>>>>>>>>>>>>>>>..>>.....<<......>>.>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<....<<..>>.....>>>>><<<<<....<<<<....>>>>...>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>..<<<<.<<<..<<<<<<<..<<<...<<...<<<<<..<<....>>...>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>...>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.(...<<<<<.......)>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<<.<<<.<<<<<<<<<<<<...........<<<<<...<<......<<<<<<<<....>>>>>>>>...>>.............>>>>>..>>>>>>>>>>>>.>>>....<<.<<<<<<.....>>>>>>>>.....>>>>>>>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.}..>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>. ((((((.......(((((((((.....(((..(((((((((((((......((((((.....[[[)))...].((((((...(((]].....)))......))))))...)))....(((....)))(((((((......))))))).(((((((((.........))))))).)).)).....(((((.....(...[..)......)))))...........((....))...((((......((.]...)).....))))...((((...((((((((....))))))))....{.(((((((((.....((((.......((((((((((.(((...(.((((......)))))[[(...).(((.....]])))...)))...)))))))))))))).)))))..)))))....((((((((..[......))))))))....}.(((((].[[[[)))))..)))......)).))))))).))...............((....))....)).........((((....)))).............).....)))))))))......(.((((..((((..[...))))..)))).<.(.(........).).((((((....(((((((.(((((..(((...(((.....)))...)))...((....))..((((.....))))......))))).)))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)<)))...(((.(((((.......A))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....((((......))))(((((((((...(((((((((.....(((...((((((((.(.(((((((.....))))).)))..))))))))..)).).....)))).)))))..))))))).))..(((((((.((......)).)))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((..(((.........)))..))).....(...((......)).).)))))...)))))))))).))...........]]].)...))))))))))...)))))))(((((((...)))))))....))))))(((((((...((......(((((.((....))])))))...))...))))).)).....))))))(......((....((((((.......))))))((((....(((...((.([((((((...((.....)).)))))))...[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((.((((((......((...((((....((((..(((..(((.(.(((.((....{..).).))).((...((((..((((.(((((((.((.....)))))))))....))))...))))...))(..((...........))...)).)))...)))...))))(..).....))))..))..))))))))))))))).])).....((......))..))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.[..).....)))))(((((....((((....))))...)))))(...).......((((((.((.>.((.........))...(((((((.....(((....))).......))))))).]((((.(((..(((((((..(((...((...(((((..((....))...)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...))..)))))).)..))).)))))))).)))))).....)).[..(((((.....>].)))))..((((((((.(((.((......((((.((((((..(((((.(((((((((.(((.((((((((((((.(.........(((((..(((......((((((((....))))))))...)))............)))))).)))))))))))).)))....((.((((((.....)))))))).....)))))))))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))..a.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}..))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((....))))....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))...))))))). Structure of the B. subtilis disome - stalled 70S ribosome; 23S rRNA 7qgu B 112 4.75 RF00001 URS00001CC3E3_1423 35264790 0003735 0005840 1423 ugguggcgauagcgaagaggucacacccguucccauaccgaacacggaaguuaagcucuucagcgccgaugguagucggggguuucccccugugagaguaggacgccgccaa <<<<<<<....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<.......<<.<<<<<...>>>>>.>>.......>>..>>>>>>>. (((((((....((((((((.....((((((...(.....)...))))..))....)))))).)).((.......((.(((((...))))).)).......))..))))))). Structure of the B. subtilis disome - stalled 70S ribosome; 5S rRNA 7qgu W 1544 4.75 RF00177,RF01959,RF01960 URS0000462957_1423 35264790 0003735 0005840 1423 ggagaguuugauccuggcucaggacgaacgcuggcggcgugccuaauacaugcaagucgagcggacagaugggagcuugcucccugauguuagcggcggacgggugaguaacacguggguaaccugccuguaagacugggauaacuccgggaaaccggggcuaauaccggaugguuguuugaaccgcaugguucaaacauaaaagguggcuucggcuaccacuuacagauggacccgcggcgcauuagcuaguuggugagguaacggcucaccaaggcgacgaugcguagccgaccugagagggugaucggccacacugggacugagacacggcccagacuccuacgggaggcagcaguagggaaucuuccgcaauggacgaaagucugacggagcaacgccgcgugagugaugaagguuuucggaucguaaagcucuguuguuagggaagaacaagugccguucgaauagggcgguaccuugacgguaccuaaccagaaagccacggcuaacuacgugccagcagccgcgguaauacguagguggcaagcguuguccggaauuauugggcguaaagggcucgcaggcgguuucuuaagucugaugugaaagcccccggcucaaccggggagggucauuggaaacuggggaacuugagugcagaagaggagaguggaauuccacguguagcggugaaaugcguagagauguggaggaacaccaguggcgaaggcgacucucuggucuguaacugacgcugaggagcgaaagcguggggagcgaacaggauuagauacccugguaguccacgccguaaacgaugagugcuaaguguuaggggguuuccgccccuuagugcugcagcuaacgcauuaagcacuccgccuggggaguacggucgcaagacugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggucuugacauccucugacaauccuagagauaggacguccccuucgggggcagagugacagguggugcaugguugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuugaucuuaguugccagcauucaguugggcacucuaaggugacugccggugacaaaccggaggaagguggggaugacgucaaaucaucaugccccuuaugaccugggcuacacacgugcuacaauggacagaacaaagggcagcgaaaccgcgagguuaagccaaucccacaaaucuguucucaguucggaucgcagucugcaacucgacugcgugaagcuggaaucgcuaguaaucgcggaucagcaugccgcggugaauacguucccgggccuuguacacaccgcccgucacaccacgagaguuuguaacacccgaagucggugagguaaccuuuuaggagccagccgccgaaggugggacagaugauuggggugaagucguaacaagguagccguaucggaaggugcggcuggaucaccuccuu ...<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<<<...<<<<<....>>>>>...>>>>.>>>>>......<<........<<<<<<<..<<...<<<<<<<.<<<<.....<<<<<<....>>>>>>......>>>>.....<<<<<<<<<<....>>>>>>>>>>.....<<<<<<....>>>>>>.>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>..<<<<<<<<.......<<<<<<<<<<<.....>>>>>>>>>.>>.......>>>>>>...>>.<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<.......<<<<<<.....>>>>>>.....>>>>>>>..>>>>>>>>>...<<<.<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>..>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<<....>>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<........<<........>>..........<<<<<<<......<<<<<<<....<<<<<....>>>>>....<<<....>>>.>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<......>>>>>...>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>......>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>.....<<<<<<.........>>>>>>.......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<..<<<<....<.<<<<..<<<..<<<...>>>.>>>.>>>>.>...>>>>..>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............. ...((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((...(((((....)))))...)))).)))))......(((.......(((((((..((...(((((((.((((.....((((((....))))))......))))......(((((((((....)))))))))......((((((....)))))).)))))))..))))))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((((((((........((((((((((.....))))))))).)........))))))...)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))...).)))))))..)))))))))..((((.((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))))..)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((......))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((.(.....(((((....)))))....(((....)))..).)).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..((......))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((..((((....(.((((..(((..(((...))).))).)))).)...))))..))))))..))).))))..).))...)..)..(((((((((....)))))))))}............ Structure of the B. subtilis disome - stalled 70S ribosome; 16S rRNA 7qgu z 77 4.75 RF00005 URS00002C7A07_1423 35264790 0030533 0006412 1423 gguccgguaguucaguugguuagaaugccugccugucacgcaggaggucgcggguucgagucccguccggaccgcca <<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.........)))).(((((.......))))).....(((((.......)))))))))))).... Structure of the B. subtilis disome - stalled 70S ribosome; P-site tRNA 7qh4 A 2923 5.45 RF02540,RF02541,RF00002 URS000081169B_1423 35264790 0003735 0005840 1423 uuaaguuagaaagggcgcacgguggaugccuuggcacuaggagccgaugaaggacgggacgaacaccgauaugcuucggggagcuguaagcaagcuuugauccggagauuuccgaauggggaaacccaccacucguaauggagugguauccauaucugaauucauaggauaugagaaggcagacccggggaacugaaacaucuaaguacccggaggaagagaaagcaaaugcgauucccugaguagcggcgagcgaaacgggaucagcccaaaccaagaggcuugccucuugggguuguaggacacucuguacggaguuacaaaggaacgagguagaugaagaggucuggaaaggcccgccauaggagguaacagcccuguagucaaaacuucguucucuccugaguggauccugaguacggcggaacacgugaaauuccgucggaauccgggaggaccaucucccaaggcuaaauacucccuagugaccgauagugaaccaguaccgugagggaaaggugaaaagcaccccggaaggggagugaaagagauccugaaaccgugugccuacaaguagucagagcccguuaacgggugauggcgugccuuuuguagaaugaaccggcgaguuacgaucucgugcaagguuaagcagaagaugcggagccgcagcgaaagcgagucugaauagggcgcaugaguacguggucguagacccgaaaccaggugaucuacccauguccagggugaaguucagguaacacugaauggaggcccgaacccacgcacguugaaaagugcggggaugagguguggguaggggugaaaugccaaucgaaccuggagauagcugguucucuccgaaauagcuuuagggcuagccucaagguaagagucuuggagguagagcacugauuggacuaggggccccuaccggguuaccgaauucagucaaacuccgaaugccaaugacuuauccuugggagucagacugcgagugauaagauccguagucgaaagggaaacagcccagaccgccagcuaaggucccaaaguauacguuaaguggaaaaggauguggaguugcuuagacaaccaggauguuggcuuagaagcagccaccauuuaaagagugcguaauagcucacuggucgagugacucugcgccgaaaauguaccggggcuaaacguaucaccgaagcugcggacuguucuucgaacagugguaggagagcguucuaagggcugugaagccagaccggaaggacugguggagcgcuuagaagugagaaugccgguaugaguagcgaaagaggggugagaauccccuccaccgaaugccuaagguuuccugaggaaggcucguccgcucaggguuagucgggaccuaagccgaggccgaaaggcguaggcgauggacaacagguugauauuccuguaccaccuccucaccauuugagcaauggggggacgcaggaggauaggguaagcgcgguauuggauauccgcguccaagcaguuaggcugggaaauaggcaaauccguuucccauaagccugagcugugauggcgagcgaaauauaguagcgaaguuccugauuccacacugccaagaaaagccucuagcgaggugagaggugcccguaccgcaaaccgacacagguaggcgaggagagaauccuaaggugaucgagagaacucucguuaaggaacucggcaaaaugaccccguaacuucgggagaaggggugcucuguuagggugcaagcccgagagagccgcagugaauaggcccaggcgacuguuuagcaaaaacacaggucucugcgaagccguaaggcgaaguauaggggcugacgccugcccggugcuggaagguuaagaggagcgcuuagcguaagcgaaggugcgaauugaagccccaguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgacccgcacgaaaggcgcaacgaucugggcacugucucaacgagagacucggugaaauuauaguaccugugaagaugcagguuacccgcgacaggacggaaagaccccguggagcuuuacugcagccugauauugaauguugguacagcuuguacaggauagguaggagccuuggaaaccggagcgccagcuucgguggaggcaucggugggauacuacccuggcuguauugaccuucuaacccgccgcccuuaucgggcggggagacagugucaggugggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguucccucagaaugguuggaaaucauucgcagaguguaaaggcacaagggagcuugacugcgagaccuacaagucgagcagggacgaaagucgggcuuagugauccggugguuccgcauggaagggccaucgcucaacggauaaaagcuaccccggggauaacaggcuuaucucccccaagaguccacaucgacggggagguuuggcaccucgaugucggcucaucgcauccuggggcuguagucggucccaaggguugggcuguucgcccauuaaagcgguacgcgagcuggguucagaacgucgugagacaguucggucccuauccgucgcgggcgcaggaaauuugagaggagcuguccuuaguacgagaggaccgggauggacgcaccgcugguguaccaguuguucugccaagggcaucgcuggguagcuaugugcggacgggauaagugcugaaagcaucuaagcaugaagccccccucaagaugagauuucccauuccgcaaggaaguaagaucccugaaagaugaucagguugauaggucugagguggaaguguggcgacacauggagcugacagauacuaaucgaucgaggacuuaac <<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<.....((.>>>.....<<<<<<<..<<<)).....>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<<<<<<<<.........>>>>>>>.>>.>>....<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<......<<.....>>.....>>>>...(((....<<<<<<<<<..>>>>>>>>>......<<<<<<<<<.....<<<<.......<<<<<<<<<<.<<<.....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>.>>>>>..>>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<......>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<.<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>......>>>>>.>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>...>.>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<...<<<<<<<<<.....<<<...<<<<<<<<...<<<<<<<.....>>>>>.>>...>>>>>>>>..>>.>.....>>>>.>>>>>..>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<.........>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<...>>>>>>>....>>>>>>..<<<<<<<.<<......<<<<<.<<....>>.>>>>>...>>.>>>>>>>........>>>>>><......<<....<<<<<<.......>>>>>><<<<....<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<.<<<<<<......<<...<<<<....<<<<..<<<..<<<.<.<<<.<.....{....>.>>>.<<...<<<<<.<<<<.<<<<<<<.<<.....>>>>>>>>>....>>>>..>>>>>...>><..<<...........>>...>>.>>>...>>>...>>>>.........>>>>..>>..>>>>>>>>>>>>>>>..>>.....<<......>>.>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<....<<..>>.....>>>>><<<<<....<<<<....>>>>...>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>..<<<<.<<<..<<<<<<<..<<<...<<...<<<<<..<<....>>...>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>...>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.(...<<<<<.......)>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<<.<<<..<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>..>>>....<<.<<<<<<.....>>>>>>>>.....>>>>>>>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.}..>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>. ((((((.......(((((((((.....(((..(((((((((((((......((((((.....[[[)))...].((((((...(((]].....)))......))))))...)))....(((....)))(((((((......))))))).(((((((((.........))))))).)).)).....(((((.....(...[..)......)))))...........((....))...((((......((.]...)).....))))...((((...((((((((....))))))))....{.(((((((((.....((((.......((((((((((.(((...(.((((......)))))[[(...).(((.....]])))...)))...)))))))))))))).)))))..)))))....((((((((..[......))))))))....}.(((((].[[[[)))))..)))......)).))))))).))...............((....))....)).........((((....)))).............).....)))))))))......(.((((..((((..[...))))..)))).<.(.(........).).((((((....(((((((.(((((..(((...(((.....)))...)))...((....))..((((.....))))......))))).)))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)<)))...(((.(((((.......A))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....((((......))))(((((((((...(((((((((.....(((...((((((((.(.(((((((.....))))).)))..))))))))..)).).....)))).)))))..))))))).))..(((((((.((......)).)))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((..(((.........)))..))).....(...((......)).).)))))...)))))))))).))...........]]].)...))))))))))...)))))))(((((((...)))))))....))))))(((((((...((......(((((.((....))])))))...))...))))).)).....))))))(......((....((((((.......))))))((((....(((...((.([((((((...((.....)).)))))))...[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((.((((((......((...((((....((((..(((..(((.(.(((.((....{..).).))).((...((((..((((.(((((((.((.....)))))))))....))))...))))...))(..((...........))...)).)))...)))...))))(..).....))))..))..))))))))))))))).])).....((......))..))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.[..).....)))))(((((....((((....))))...)))))(...).......((((((.((.>.((.........))...(((((((.....(((....))).......))))))).]((((.(((..(((((((..(((...((...(((((..((....))...)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...))..)))))).)..))).)))))))).)))))).....)).[..(((((.....>].)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((..(((((.(((((.(.........(((((..(((......((((((((....))))))))...)))............)))))).))))).)))))..)))....((.((((((.....)))))))).....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))..a.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}..))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((....))))....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))...))))))). Structure of the B. subtilis disome - collided 70S ribosome; 23S rRNA 7qh4 B 112 5.45 RF00001 URS00001CC3E3_1423 35264790 0003735 0005840 1423 ugguggcgauagcgaagaggucacacccguucccauaccgaacacggaaguuaagcucuucagcgccgaugguagucggggguuucccccugugagaguaggacgccgccaa <<<<<<<....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<.......<<.<<<<<...>>>>>.>>.......>>..>>>>>>>. (((((((....((((((((.....((((((...(.....)...))))..))....)))))).)).((.......((.(((((...))))).)).......))..))))))). Structure of the B. subtilis disome - collided 70S ribosome; 5S rRNA 7qh4 W 1544 5.45 RF00177,RF01959,RF01960 URS0000462957_1423 35264790 0003735 0005840 1423 ggagaguuugauccuggcucaggacgaacgcuggcggcgugccuaauacaugcaagucgagcggacagaugggagcuugcucccugauguuagcggcggacgggugaguaacacguggguaaccugccuguaagacugggauaacuccgggaaaccggggcuaauaccggaugguuguuugaaccgcaugguucaaacauaaaagguggcuucggcuaccacuuacagauggacccgcggcgcauuagcuaguuggugagguaacggcucaccaaggcgacgaugcguagccgaccugagagggugaucggccacacugggacugagacacggcccagacuccuacgggaggcagcaguagggaaucuuccgcaauggacgaaagucugacggagcaacgccgcgugagugaugaagguuuucggaucguaaagcucuguuguuagggaagaacaagugccguucgaauagggcgguaccuugacgguaccuaaccagaaagccacggcuaacuacgugccagcagccgcgguaauacguagguggcaagcguuguccggaauuauugggcguaaagggcucgcaggcgguuucuuaagucugaugugaaagcccccggcucaaccggggagggucauuggaaacuggggaacuugagugcagaagaggagaguggaauuccacguguagcggugaaaugcguagagauguggaggaacaccaguggcgaaggcgacucucuggucuguaacugacgcugaggagcgaaagcguggggagcgaacaggauuagauacccugguaguccacgccguaaacgaugagugcuaaguguuaggggguuuccgccccuuagugcugcagcuaacgcauuaagcacuccgccuggggaguacggucgcaagacugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggucuugacauccucugacaauccuagagauaggacguccccuucgggggcagagugacagguggugcaugguugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuugaucuuaguugccagcauucaguugggcacucuaaggugacugccggugacaaaccggaggaagguggggaugacgucaaaucaucaugccccuuaugaccugggcuacacacgugcuacaauggacagaacaaagggcagcgaaaccgcgagguuaagccaaucccacaaaucuguucucaguucggaucgcagucugcaacucgacugcgugaagcuggaaucgcuaguaaucgcggaucagcaugccgcggugaauacguucccgggccuuguacacaccgcccgucacaccacgagaguuuguaacacccgaagucggugagguaaccuuuuaggagccagccgccgaaggugggacagaugauuggggugaagucguaacaagguagccguaucggaaggugcggcuggaucaccuccuu ...<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<<<...<<<<<....>>>>>...>>>>.>>>>>......<<........<<<<<<<..<<...<<<<<<<.<<<<.....<<<<<<....>>>>>>......>>>>.....<<<<<<<<<<....>>>>>>>>>>.....<<<<<<....>>>>>>.>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>..<<<<<<<<.......<<<<<<<<<<<.....>>>>>>>>>.>>.......>>>>>>...>>.<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<.......<<<<<<.....>>>>>>.....>>>>>>>..>>>>>>>>>...<<<.<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>..>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<<....>>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<........<<........>>..........<<<<<<<......<<<<<<<....<<<<<....>>>>>....<<<....>>>.>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<......>>>>>...>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>......>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>.....<<<<<<.........>>>>>>.......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<..<<<<....<.<<<<..<<<..<<<...>>>.>>>.>>>>.>...>>>>..>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............. ...((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((...(((((....)))))...)))).)))))......(((.......(((((((..((...(((((((.((((.....((((((....))))))......))))......(((((((((....)))))))))......((((((....)))))).)))))))..))))))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((((((((........((((((((((.....))))))))).)........))))))...)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))...).)))))))..)))))))))..((((.((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))))..)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((......))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((.(.....(((((....)))))....(((....)))..).)).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..((......))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((..((((....(.((((..(((..(((...))).))).)))).)...))))..))))))..))).))))..).))...)..)..(((((((((....)))))))))}............ Structure of the B. subtilis disome - collided 70S ribosome; 16S rRNA 7qh4 y 77 5.45 RF00005 URS00002C7A07_1423 35264790 0030533 0006412 1423 gguccgguaguucaguugguuagaaugccugccugucacgcaggaggucgcggguucgagucccguccggaccgcca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ..(((((..((((.........)))).(((((.......))))).....(((((.......))))))))))...... Structure of the B. subtilis disome - collided 70S ribosome; tRNA 7qh4 1 77 5.45 RF00005 URS00002C7A07_1423 35264790 0030533 0006412 1423 gguccgguaguucaguugguuagaaugccugccugucacgcaggaggucgcggguucgagucccguccggaccgcca <<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.........)))).(((((.......))))).....(((((.......)))))))))))).... Structure of the B. subtilis disome - collided 70S ribosome; tRNA 7qi4 AA 954 2.21 RF00177 URS00008F947B_9606 38769321,38769321,37503168 0003735 0005840 9606 auagguuugguccuagccuuucuauuagcucuuaguaagauuacacaugcaagcauccccguuccagugaguucacccucuaaaucaccacgaucaaaagggacaagcaucaagcacgcagcaaugcagcucaaaacgcuuagccuagccacacccccacgggaaacagcagugauuaaccuuuagcaauaaacgaaaguuuaacuaagcuauacuaaccccaggguuggucaauuucgugccagccaccgcggucacacgauuaacccaagucaauagaagccggcguaaagaguguuuuagaucacccccuccccaauaaagcuaaaacucaccugaguuguaaaaaacuccaguugacacaaaauagacuacgaaaguggcuuuaacauaucugaacacacaauagcuaagacccaaacuggganuagauaccccacuaugcuuagcccuaaaccucaacaguuaaaucaacaaaacugcucgccagaacacuacgagccacagcuuaaaacucaaaggaccuggcggugcuucauaucccucuagaggagccuguucuguaaucgauaaaccccgaucaaccucaccaccucuugcucagccuauauaccgccaucuucagcaaacccugaugaaggcuacaaaguaagcgcaaguacccacguaaagacguuaggucaagguguagcccaugagguggcaagaaaugggcuacauuuucuaccccagaaaacuacgauagcccuuaugaaacuuaagggucgaagguggauuuagcaguaaacugagaguagagugcuuaguugaacagggcccugaagcgcguacacaccgncngucacccuccucaaguauacuucaaaggacauuuaacuaaaaccccuacgcauuuauauagaggagacaagucguaacaugguaaguguacuggnnagugcacuuggacgaacc ..((((..<<<<<<.)))).<<<<<<.<<..<<<<<<<<....<<<.<<<..<......>......<<.......<<<<.<..<<<.....>>>.>..>>>>..<<<<....<<...<<<....>>>..>>......>>>>.<<...>>.>>.<<<....>>>.....>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>.....<<<<<<<<.....(((.....((.>>>)).......)))..>>>>>..>>.>>>>>>....<<<((.....<<<<..<<<<...............<<<<<<......<<<.<<<.<<<......>>>..>>>.>>>.............<<....>>.>>>>>>.....>>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<.<<<<<......))..>>>>>.>.>>>.<<.......<<<<....>>>>.....>>..>>>>>><<<<<.<<<<<<<...<<<.<<<<<..<<<<<<<<<<.....<<........>>..........<<<<<<<.......<<.<<<..<<<<<<.......<<..<<<<<.....>>>.......>>..>>.....<<<....>>>.........>>>...>>>>>>>>....>>>>>>>..>>.>>>>>>>>.....<<<<.....>>>>.....<....<<<<<<<.......>>>>>>>....>.....>>>>>.....<<<<<<<.........>>>>>>>.....>>>...>>>>>>>>>>.>>....<..<<.<...<<<<<<..<<<<<......<<<...<<<.....>>>..>>>.......>>>>>.>>>>>>....>.>>...>.....<<<<<<<<<....>>>>>>>>>......... [.[[[[..(((((..]]]]]((((((.((..((((((((..(.(((.(((..(......)......(((......((((.(..(((.....))).)..))))..((((....((..((((....))).)))......)))).((...))))).(((....))).....)))))))......(.(((...(((((....)))).))))).)).)))))).....((((([[[.....(((.....((.]]])).......)))..)))))..)).))))))....((([[...(.((((...(((...............(((((((.....(((.(((.((........))..))).))).....).....(.((....))))))))).....)))....))))....((((((...((...((((.........))))...))))))))......{...(.(((((......]]..))))).))))).((.......((((....)))).....))...)))))(((((.(((((((...(((.(((((..((((((((((.....((........))..........(((((((.......((.(((...((((((.(....((..(((((.....))).......))..)).....(((....))).....).).)))...)).)))))....)))))))..)).)))))))).(...((((.....)))).....(....(((((((.......)))))))....)..)..))))).....(((((((.........))))))).....)))...)))))))))).))..(.(..((.(...((((((...((((..((..(((....((.....))...)))..).)..))))..))))))....).))...)..)..(((((((((....)))))))))}........ Human mitochondrial ribosome at 2.2 A resolution (bound to partly built tRNAs and mRNA); 12S mitochondrial rRNA 7qi4 Aw 22 2.21 URS00023359DE_9606 38769321,38769321,37503168 9606 gaaugauuaacacucauuacca .<<<<<.......>>>>>.... .(((((.......))))).... Human mitochondrial ribosome at 2.2 A resolution (bound to partly built tRNAs and mRNA); A/A-tRNA 7qi4 Ax 70 2.21 RF00005 URS000268144D_9606 38769321,38769321,37503168 0030533 0006412 9606 uagggaauaguuuaaaaaacaucugacucauauucagaagauggagguucaauuccuccuucccuaacca <<<<<<<..<<<<...>>>>.<<<<<.......>>>>>....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...)))).(((((.......)))))....(((((.......)))))))))))).... Human mitochondrial ribosome at 2.2 A resolution (bound to partly built tRNAs and mRNA); P/P-tRNA 7qi4 Az 34 2.21 38769321,38769321,37503168 9606 uuuaaaugguuguuuauaaaaaaauuuacuuaaa .................................. .................................. Human mitochondrial ribosome at 2.2 A resolution (bound to partly built tRNAs and mRNA); mRNA 7qi4 A 1558 2.21 RF02541,RF02540 URS00023359E4_9606 38769321,38769321,37503168 0003735 0005840 9606 gcuaaaccuagccccaaacccacuccaccuuacuaccagacaaccuuagccaaaccauuuacccaaauaaaguauaggcgauagaaauugaaaccuggcgcaauagauauaguaccgcaagggaaagaugaaaaauuauaaccaagcauaauauagcaaggacuaaccccuauaccuucugcauaaugaauuaacuagaaauaacuuugcaaggagagccaaagcuaagacccccgaaaccagacgagcuaccuaagaacagcuaaaagagcacacccgucuauguagcaaaauagugggaagauuuauagguagaggcgacaaaccuaccgagccuggugauagcugguuguccaagauagaaucuuaguucaacuuuaaauuugcccacagaacccucuaaauccccuuguaaauuuaacuguuaguccaaagaggaacagcucuuuggacacuaggaaaaaaccuuguagagagaguaaaaaauuuaacacccauaguaggccuaaaagcagccaccaauuaagaaagcguucaagcucaacacccacuaccuaaaaaaucccaaacauauaacugaacuccucacacccaauuggaccaaucuaucacccuauagaagaacuaauguuaguauaaguaacaugaaaacauucuccuccgcauaagccugcgucagauuaaaacgaacugacaauuaacagcccaauaucuacaaucaaccaacaagucauuauuacccucacugucaacccaacacaggcaugcucauaaggaaagguuaaaaaaaguaaaaggaacucggcaaaucuuaccccgccuguuuaccaaaaacaucaccucuagcaucaccaguauuagaggcaccgccugcccagugacacauguuuaacggccgcgguacccuaaccgugcaaagguagcauaaucacuuguuccuuaanuagggaccuguaugaauggcuccacgaggguucagcugucucuuacuuuuaaccagugaaauugaccugcccgugaagaggcgggcauaacacagcaagacgagaagacccuauggagcuuuaauuuauuaaugcaaacaguaccuaacaaacccacagguccuaaacuaccaaaccugcauuaaaaauuucgguugnggcgaccucggagcagaacccaaccuccgagcaguacaugcuaagacuucaccagucaaagcgaacuacuauacucaauugauccaauaacuugaccaacggaacaaguuacccuagggauaacagcgcaauccuauucuagaguccauaucaacaauaggguuuacgaccucgauguuggaucaggacaucccgauggugcagccgcuauuaaagguucguunnuucaacgauuaaaguccuacgugaucugaguucagaccggaguaauccaggucgguuucuaucuacuuucaaauuccucccuguacgaaaggacaagagaaauaaggccuacuucacaaagcgccuucccccguaaaugauaucaucucaacuuaguauuauacccacacccacccaagaacaggguuugu <<<.......<<<<.....................................<......>.........<.....<<.....>>....>........>>.>>.............<<....>>......................>>>...........<<<.......>>>...<.<........>.>.<<<<<<.........<<<.<<..<<....>>...>>.>>>...<<.<...<<<<.<.....<<<<<.<<<..<<<.....>>>...<<<..<<<<........>>>>.>>>....>>>.>>>>>...<<.......>>......>.>>>>......>.>>..<<<<<<....<<<<....>>>><<<.<<<<<<<<<<.....<<..........>>.....>>>>>>>>>>..>>>.<<<<<<<<<<......>>>>>>>>>>...<<<......>>>....<<<.<<<...<..............<....<<<.........>>>....>.......<<<......>>>....................................>...>>>>>>........>>>>>>...<<<<<......>>>>>.........>>>>>><......<<..<<<....>>><<<<..<<<<........<<<<<..<.....>..>>>>>......<<<...<<<<.......................>>>>.......>>>.....<<......>>.>>>>.....>>>>..<<<<...<<<<<<<<.<<.........<......<<<<<<..<<<.........>>>...<<<<<<.............>>>>>>....<<<.<<<..<<<<<....>>>..>>>>><<<<<<......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>....>>.>>>>.....>..>>.>>>>>>>>>>>>.>>.....>.....<<<<<........>>>>>.......<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<....<<.........<<<....>>>........>>......>>>>>>>>>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<.....<<<..<<<<.....>>>>..>>>...........>>.........<<<....>>>............>>>>..>>>>>>.......<<<..<.<<<<<<...<<.......>>...>>>>>>...>.>>.>.......<<<<<.<<<<<<..<<.<<<<<<......>>>>>>...>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>...<.<<<.<<<.................>>>.>>><<<<<...<<<....>>>.>>>>>......<<<................>>>......>..........<<<<.......>>>>.... ((.....(..((((.....................................(...[..).........(.....((.]...))....)........)).)).............((....))....)..................)).........(.(((.......))).[.(.(........).).((((((.........(((.((..((....))...)).)))...((.(...((((.(.....(((((.((((.(((....[)))...(((..((((.......{)))).)))..).))).))))).(.((.......))...)..).))))......).))..((((((....((((....)))).((.((((((((((.....((..........)).....))))))))))..))..((((((((((......))))))))))...(((......)))....(((.(((...(..............(.(..(((.........)))..).)....(..(((......))))...................................)...))))))........))))))...(((((......))))).........))))))(......((..(((....)))(((...((((......(.(((((.((.....)).)))))......(((...((((...............(..)....)))).......))).)...((......)).))))......)))..((((....(((((((.((..(....(........((((((.].((.........))....((((((.............))))))....(((.(((..(((((....)))..)))))(((((........)))))........((..........(((((.......)))))..)..)....)))....)).))))....)..))).))))))).)))).)).....)).{..(((((.....]}.))))).......((..(((.((......((((.((((((..(((((.((((((((....(((........(((....))).......)))......)))))))))))))..(((......[)))((((((..........]))))))(.((.....((...(((....[..)))...))...........)).........(((....))).....)].....))))..))))))......((((..(.((((((.(.((.......)))..))))))...).)).).)......(.((.((((((..((.((((((......))))))...)).(((((.....))))).....)))))..)...))..).....(((((((....))).))))..}.))..))).))...(.(((.(((......(....).....))).)))(((((...(((....))).)))))......(((................)))......).........(((((.......))))..). Human mitochondrial ribosome at 2.2 A resolution (bound to partly built tRNAs and mRNA); 16S mitochondrial rRNA 7qi4 Ay 52 2.21 RF00005 URS0002681462_9606 38769321,38769321,37503168 0030533 9606 uagggaauaguuuaaaaaacagcagauggagguauuccuccuucccuaacca <<<<<<<..<<<<...>>>>.......<<<<<....>>>>>>>>>>>>.... (((((((..((((...)))).()....(((((....)))))))))))).... Human mitochondrial ribosome at 2.2 A resolution (bound to partly built tRNAs and mRNA); E/E-tRNA 7qi5 AA 954 2.63 RF00177 URS00008F947B_9606 38769321,38769321,37503168 0003735 0005840 9606 auagguuugguccuagccuuucuauuagcucuuaguaagauuacacaugcaagcauccccguuccagugaguucacccucuaaaucaccacgaucaaaagggacaagcaucaagcacgcagcaaugcagcucaaaacgcuuagccuagccacacccccacgggaaacagcagugauuaaccuuuagcaauaaacgaaaguuuaacuaagcuauacuaaccccaggguuggucaauuucgugccagccaccgcggucacacgauuaacccaagucaauagaagccggcguaaagaguguuuuagaucacccccuccccaauaaagcuaaaacucaccugaguuguaaaaaacuccaguugacacaaaauagacuacgaaaguggcuuuaacauaucugaacacacaauagcuaagacccaaacuggganuagauaccccacuaugcuuagcccuaaaccucaacaguuaaaucaacaaaacugcucgccagaacacuacgagccacagcuuaaaacucaaaggaccuggcggugcuucauaucccucuagaggagccuguucuguaaucgauaaaccccgaucaaccucaccaccucuugcucagccuauauaccgccaucuucagcaaacccugaugaaggcuacaaaguaagcgcaaguacccacguaaagacguuaggucaagguguagcccaugagguggcaagaaaugggcuacauuuucuaccccagaaaacuacgauagcccuuaugaaacuuaagggucgaagguggauuuagcaguaaacugagaguagagugcuuaguugaacagggcccugaagcgcguacacaccgncngucacccuccucaaguauacuucaaaggacauuuaacuaaaaccccuacgcauuuauauagaggagacaagucguaacaugguaaguguacuggnnagugcacuuggacgaacc ..((((..<<<<<<.)))).<<<<<<.<<..<<<<<<<<....<<<.<<<..<......>......<<.......<<<<.<..<<<.....>>>.>..>>>>..<<<<....<<...<<<....>>>..>>......>>>>.<<...>>.>>.<<<....>>>.....>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>.....<<<<<<<<.....(((.....((.>>>)).......)))..>>>>>..>>.>>>>>>....<<<((.....<<<<..<<<<...............<<<<<<......<<<.<<<.<<<......>>>..>>>.>>>.............<<....>>.>>>>>>.....>>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<.<<<<<......))..>>>>>.>.>>>.<<.......<<<<....>>>>.....>>..>>>>>><<<<<.<<<<<<<...<<<.<<<<<..<<<<<<<<<<.....<<........>>..........<<<<<<<.......<<.<<<..<<<<<<.......<<..<<<<<.....>>>.......>>..>>.....<<<....>>>.........>>>...>>>>>>>>....>>>>>>>..>>.>>>>>>>>.....<<<<.....>>>>.....<....<<<<<<<.......>>>>>>>....>.....>>>>>.....<<<<<<<.........>>>>>>>.....>>>...>>>>>>>>>>.>>....<..<<.<...<<<<<<..<<<<<......<<<...<<<.....>>>..>>>.......>>>>>.>>>>>>....>.>>...>.....<<<<<<<<<....>>>>>>>>>......... [.[[[[..(((((..]]]]]((((((.((..((((((((..(.(((.(((..(......)......(((......((((.(..(((.....))).)..))))..((((....((..((((....))).)))......)))).((...))))).(((....))).....)))))))......(.(((...(((((....)))).))))).)).)))))).....((((([[[.....(((.....((.]]])).......)))..)))))..)).))))))....((([[...(.((((...(((...............(((((((.....(((.(((.((........))..))).))).....).....(.((....))))))))).....)))....))))....((((((...((...((((.........))))...))))))))......{...(.(((((......]]..))))).))))).((.......((((....)))).....))...)))))(((((.(((((((...(((.(((((..((((((((((.....((........))..........(((((((.......((.(((...((((((.(....((..(((((.....))).......))..)).....(((....))).....).).)))...)).)))))....)))))))..)).)))))))).(...((((.....)))).....(....(((((((.......)))))))....)..)..))))).....(((((((.........))))))).....)))...)))))))))).))..(.(..((.(...((((((...((((..((..(((....((.....))...)))..).)..))))..))))))....).))...)..)..(((((((((....)))))))))}........ Human mitochondrial ribosome in complex with mRNA, A/A-, P/P- and E/E-tRNAs at 2.63 A resolution; 12S mitochondrial rRNA 7qi5 Aw 68 2.63 URS0002681443_9606 38769321,38769321,37503168 9606 ugguauauaguuuaaacaaaacuaaugauuaacacucauuaaauuaugauaaucauauuuaccaucca <<<<<....<<<<.....>>>><<<<<<.......>>>>>>...<<<<<...>>>>>..>>>>>.... (((((.(..(((.......)))((((((.......))))))...(((((...)))))).))))).... Human mitochondrial ribosome in complex with mRNA, A/A-, P/P- and E/E-tRNAs at 2.63 A resolution; A/A-tRNA 7qi5 Ax 70 2.63 RF00005 URS000268144D_9606 38769321,38769321,37503168 0030533 0006412 9606 uagggaauaguuuaaaaaacaucugacucauauucagaagauggagguucaauuccuccuucccuaacca <<<<<<<..<<<<...>>>>.<<<<<.......>>>>>....<<<<<.......>>>>>>>>>>>>.... (((((((..((.(...).)).(((((.......)))))....(((((.......)))))))))))).... Human mitochondrial ribosome in complex with mRNA, A/A-, P/P- and E/E-tRNAs at 2.63 A resolution; P/P-tRNA 7qi5 Ay 70 2.63 RF00005 URS00021ED990_9606 38769321,38769321,37503168 0030533 0006412 9606 uagggaauaguuuaaaaaacagcugacuuucaaucagcagauggagguucaauuccuccuucccuaacca <<<<<<<..<<<<...>>>>.<<<<<.......>>>>>....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...)))).(.(((.......))).)....(((((.......)))))))))))).... Human mitochondrial ribosome in complex with mRNA, A/A-, P/P- and E/E-tRNAs at 2.63 A resolution; E/E-tRNA 7qi5 Az 34 2.63 38769321,38769321,37503168 9606 uuuaaaugguuguuuauaaaaaaauuuacuuaaa .................................. .................................. Human mitochondrial ribosome in complex with mRNA, A/A-, P/P- and E/E-tRNAs at 2.63 A resolution; mRNA 7qi5 A 1558 2.63 RF02541 URS00021ED93A_9606 38769321,38769321,37503168 0003735 0005840 9606 gcuaaaccuagccccaaacccacuccaccuuacuaccagacaaccuuagccaaaccauuuacccaaauaaaguauaggcgauagaaauugaaaccuggcgcaauagauauaguaccgcaagggaaagaugaaaaauuauaaccaagcauaauauagcaaggacuaaccccuauaccuucugcauaaugaauuaacuagaaauaacuuugcaaggagagccaaagcuaagacccccgaaaccagacgagcuaccuaagaacagcuaaaagagcacacccgucuauguagcaaaauagugggaagauuuauagguagaggcgacaaaccuaccgagccuggugauagcugguuguccaagauagaaucuuaguucaacuuuaaauuugcccacagaacccucuaaauccccuuguaaauuuaacuguuaguccaaagaggaacagcucuuuggacacuaggaaaaaaccuuguagagagaguaaaaaauuuaacacccauaguaggccuaaaagcagccaccaauuaagaaagcguucaagcucaacacccacuaccuaaaaaaucccaaacauauaacugaacuccucacacccaauuggaccaaucuaucacccuauagaagaacuaauguuaguauaaguaacaugaaaacauucuccuccgcauaagccugcgucagauuaaaacgaacugacaauuaacagcccaauaucuacaaucaaccaacaagucauuauuacccucacugucaacccaacacaggcaugcucauaaggaaagguuaaaaaaaguaaaaggaacucggcaaaucuuaccccgccuguuuaccaaaaacaucaccucuagcaucaccaguauuagaggcaccgccugcccagugacacauguuuaacggccgcgguacccuaaccgugcaaagguagcauaaucacuuguuccuuaanuagggaccuguaugaauggcuccacgaggguucagcugucucuuacuuuuaaccagugaaauugaccugcccgugaagaggcgggcauaacacagcaagacgagaagacccuauggagcuuuaauuuauuaaugcaaacaguaccuaacaaacccacagguccuaaacuaccaaaccugcauuaaaaauuucgguugnggcgaccucggagcagaacccaaccuccgagcaguacaugcuaagacuucaccagucaaagcgaacuacuauacucaauugauccaauaacuugaccaacggaacaaguuacccuagggauaacagcgcaauccuauucuagaguccauaucaacaauaggguuuacgaccucgauguuggaucaggacaucccgauggugcagccgcuauuaaagguucguunnuucaacgauuaaaguccuacgugaucugaguucagaccggaguaauccaggucgguuucuaucuacuuucaaauuccucccuguacgaaaggacaagagaaauaaggccuacuucacaaagcgccuucccccguaaaugauaucaucucaacuuaguauuauacccacacccacccaagaacaggguuugu <<<.......<<<<.....................................<......>.........<.....<<.....>>....>........>>.>>.............<<....>>......................>>>...........<<<.......>>>...<.<........>.>.<<<<<<.........<<<.<<..<<....>>...>>.>>>...<<.<...<<<<.<.....<<<<<.<<<..<<<.....>>>...<<<..<<<<........>>>>.>>>....>>>.>>>>>...<<.......>>......>.>>>>......>.>>..<<<<<<....<<<<....>>>><<<.<<<<<<<<<<.....<<..........>>.....>>>>>>>>>>..>>>.<<<<<<<<<<......>>>>>>>>>>...<<<......>>>....<<<.<<<...<..............<....<<<.........>>>....>.......<<<......>>>....................................>...>>>>>>........>>>>>>...<<<<<......>>>>>.........>>>>>><......<<..<<<....>>><<<<..<<<<........<<<<<..<.....>..>>>>>......<<<...<<<<.......................>>>>.......>>>.....<<......>>.>>>>.....>>>>..<<<<...<<<<<<<<.<<.........<......<<<<<<..<<<.........>>>...<<<<<<.............>>>>>>....<<<.<<<..<<<<<....>>>..>>>>><<<<<<......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>....>>.>>>>.....>..>>.>>>>>>>>>>>>.>>.....>.....<<<<<........>>>>>.......<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<....<<<........<<<....>>>.......>>>......>>>>>>>>>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<.....<<<..<<<<.....>>>>..>>>...........>>.........<<<....>>>............>>>>..>>>>>>.......<<<..<.<<<<<<...<<.......>>...>>>>>>...>.>>.>.......<<<<<.<<<<<<..<<.<<<<<<......>>>>>>...>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>...<.<<<.<<<.................>>>.>>><<<<<...<<<....>>>.>>>>>......<<<................>>>......>..........<<<<.......>>>>.... ((.....(..((((.....................................(...[..).........(.....((.]...))....)........)).)).............((....))....)..................)).........(.(((.......))).[.(.(........).).((((((.........(((.((..((....))...)).)))...((.(...((((.(.....(((((.((((.(((....[)))...(((..((((.......{)))).)))..).))).))))).(.((.......))...)..).))))......).))..((((((....((((....)))).((.((((((((((.....((..........)).....))))))))))..))..((((((((((......))))))))))...(((......)))....(((.(((...(..............(.(..(((.........)))..).)....(..(((......))))...................................)...))))))........))))))...(((((......))))).........))))))(......((..(((....)))(((...((((......(.(((((.((.....)).)))))......(((...((((...............(..)....)))).......))).)...((......)).))))......)))..((((....(((((((.((..(....(........((((((.].((.........))....((((((.............))))))....(((.(((..(((((....)))..)))))(((((........)))))........((..........(((((.......)))))..)..)....)))....)).))))....)..))).))))))).)))).)).....)).{..(((((.....]}.))))).......((..(((.((......((((.((((((..(((((.((((((((....(((........(((....))).......)))......)))))))))))))..(((......[)))((((((..........]))))))(.((.....((...(((....[..)))...))...........)).........(((....))).....)].....))))..))))))......((((..(.((((((.(.((.......)))..))))))...).)).).)......(.((.((((((..((.((((((......))))))...)).(((((.....))))).....)))))..)...))..).....(((((((....))).))))..}.))..))).))...(.(((.(((......(....).....))).)))(((((...(((....))).)))))......(((................)))......).........(((((.......))))..). Human mitochondrial ribosome in complex with mRNA, A/A-, P/P- and E/E-tRNAs at 2.63 A resolution; 16S mitochondrial rRNA 7qi6 AA 954 2.98 RF00177 URS00008F947B_9606 38769321,38769321,37503168 0003735 0005840 9606 auagguuugguccuagccuuucuauuagcucuuaguaagauuacacaugcaagcauccccguuccagugaguucacccucuaaaucaccacgaucaaaagggacaagcaucaagcacgcagcaaugcagcucaaaacgcuuagccuagccacacccccacgggaaacagcagugauuaaccuuuagcaauaaacgaaaguuuaacuaagcuauacuaaccccaggguuggucaauuucgugccagccaccgcggucacacgauuaacccaagucaauagaagccggcguaaagaguguuuuagaucacccccuccccaauaaagcuaaaacucaccugaguuguaaaaaacuccaguugacacaaaauagacuacgaaaguggcuuuaacauaucugaacacacaauagcuaagacccaaacuggganuagauaccccacuaugcuuagcccuaaaccucaacaguuaaaucaacaaaacugcucgccagaacacuacgagccacagcuuaaaacucaaaggaccuggcggugcuucauaucccucuagaggagccuguucuguaaucgauaaaccccgaucaaccucaccaccucuugcucagccuauauaccgccaucuucagcaaacccugaugaaggcuacaaaguaagcgcaaguacccacguaaagacguuaggucaagguguagcccaugagguggcaagaaaugggcuacauuuucuaccccagaaaacuacgauagcccuuaugaaacuuaagggucgaagguggauuuagcaguaaacugagaguagagugcuuaguugaacagggcccugaagcgcguacacaccgncngucacccuccucaaguauacuucaaaggacauuuaacuaaaaccccuacgcauuuauauagaggagacaagucguaacaugguaaguguacuggnnagugcacuuggacgaacc ..((((..<<<<<<.)))).<<<<<<.<<..<<<<<<<<....<<<.<<<..<......>......<<.......<<<<.<..<<<.....>>>.>..>>>>..<<<<....<<...<<<....>>>..>>......>>>>.<<...>>.>>.<<<....>>>.....>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>.....<<<<<<<<.....(((.....((.>>>)).......)))..>>>>>..>>.>>>>>>....<<<((.....<<<<..<<<<...............<<<<<<......<<<.<<<.<<<......>>>..>>>.>>>.............<<....>>.>>>>>>.....>>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<.<<<<<......))..>>>>>.>.>>>.<<.......<<<<....>>>>.....>>..>>>>>><<<<<.<<<<<<<...<<<.<<<<<..<<<<<<<<<<.....<<........>>..........<<<<<<<.......<<.<<<..<<<<<<.......<<..<<<<<.....>>>.......>>..>>.....<<<....>>>.........>>>...>>>>>>>>....>>>>>>>..>>.>>>>>>>>.....<<<<.....>>>>.....<....<<<<<<<.......>>>>>>>....>.....>>>>>.....<<<<<<<.........>>>>>>>.....>>>...>>>>>>>>>>.>>....<..<<.<...<<<<<<..<<<<<......<<<....<<.....>>...>>>.......>>>>>.>>>>>>....>.>>...>.....<<<<<<<<<....>>>>>>>>>......... [.[[[[..(((((..]]]]]((((((.((..((((((((..(.(((.(((..(......)......(((......((((.(..(((.....))).)..))))..((((....((..((((....))).)))......)))).((...))))).(((....))).....)))))))......(.(((...(((((....)))).))))).)).)))))).....((((([[[.....(((.....((.]]])).......)))..)))))..)).))))))....((([[...(.((((...(((...............(((((((.....(((.(((.((........))..))).))).....).....(.((....))))))))).....)))....))))....((((((...((...((((.........))))...))))))))......{...(.(((((......]]..))))).))))).((.......((((....)))).....))...)))))(((((.(((((((...(((.(((((..((((((((((.....((........))..........(((((((.......((.(((...((((((.(....((..(((((.....))).......))..)).....(((....))).....).).)))...)).)))))....)))))))..)).)))))))).(...((((.....)))).....(....(((((((.......)))))))....)..)..))))).....(((((((.........))))))).....)))...)))))))))).))..(.(..((.(...((((((...((((..(...(((....((.....))...)))....)..))))..))))))....).))...)..)..(((((((((....)))))))))}........ Human mitochondrial ribosome in complex with mRNA, A/P- and P/E-tRNAs at 2.98 A resolution; 12S mitochondrial rRNA 7qi6 Az 33 2.98 38769321,38769321,37503168 9606 uuaaaugguaguuuauaaaaaaauuuacuuaaa ................................. ................................. Human mitochondrial ribosome in complex with mRNA, A/P- and P/E-tRNAs at 2.98 A resolution; mRNA 7qi6 Aw 68 2.98 URS0002681401_9606 38769321,38769321,37503168 9606 ugguauauaguuuaaacaaaacgaaugauuuacacucauucaauuaugauaaucauauuuaccaacca <...<....<<<.......>>><<<<<<.......>>>>>>...<<<<<...>>>>>.>....>.... ....(....(((.......)))((((((.......))))))...(.(((...))).).)......... Human mitochondrial ribosome in complex with mRNA, A/P- and P/E-tRNAs at 2.98 A resolution; A/P-tRNA 7qi6 Ax 71 2.98 RF00005 URS0002681406_9606 38769321,38769321,37503168 0030533 0006412 9606 uagggaauaguuuaacaaaacuccugacucauccucaggagauggagguucaauuccuccuucccuaacca <<<<<<<...<<<....>>><<<<<<<.......>>>>>>>..<<<<<.......>>>>>>>>>>>>.... (((((((...(((....)))..(((((.......)))))....(((((.......)))))))))))).... Human mitochondrial ribosome in complex with mRNA, A/P- and P/E-tRNAs at 2.98 A resolution; P/E-tRNA 7qi6 A 1558 2.98 RF02541 URS00021ED93A_9606 38769321,38769321,37503168 0003735 0005840 9606 gcuaaaccuagccccaaacccacuccaccuuacuaccagacaaccuuagccaaaccauuuacccaaauaaaguauaggcgauagaaauugaaaccuggcgcaauagauauaguaccgcaagggaaagaugaaaaauuauaaccaagcauaauauagcaaggacuaaccccuauaccuucugcauaaugaauuaacuagaaauaacuuugcaaggagagccaaagcuaagacccccgaaaccagacgagcuaccuaagaacagcuaaaagagcacacccgucuauguagcaaaauagugggaagauuuauagguagaggcgacaaaccuaccgagccuggugauagcugguuguccaagauagaaucuuaguucaacuuuaaauuugcccacagaacccucuaaauccccuuguaaauuuaacuguuaguccaaagaggaacagcucuuuggacacuaggaaaaaaccuuguagagagaguaaaaaauuuaacacccauaguaggccuaaaagcagccaccaauuaagaaagcguucaagcucaacacccacuaccuaaaaaaucccaaacauauaacugaacuccucacacccaauuggaccaaucuaucacccuauagaagaacuaauguuaguauaaguaacaugaaaacauucuccuccgcauaagccugcgucagauuaaaacgaacugacaauuaacagcccaauaucuacaaucaaccaacaagucauuauuacccucacugucaacccaacacaggcaugcucauaaggaaagguuaaaaaaaguaaaaggaacucggcaaaucuuaccccgccuguuuaccaaaaacaucaccucuagcaucaccaguauuagaggcaccgccugcccagugacacauguuuaacggccgcgguacccuaaccgugcaaagguagcauaaucacuuguuccuuaanuagggaccuguaugaauggcuccacgaggguucagcugucucuuacuuuuaaccagugaaauugaccugcccgugaagaggcgggcauaacacagcaagacgagaagacccuauggagcuuuaauuuauuaaugcaaacaguaccuaacaaacccacagguccuaaacuaccaaaccugcauuaaaaauuucgguugnggcgaccucggagcagaacccaaccuccgagcaguacaugcuaagacuucaccagucaaagcgaacuacuauacucaauugauccaauaacuugaccaacggaacaaguuacccuagggauaacagcgcaauccuauucuagaguccauaucaacaauaggguuuacgaccucgauguuggaucaggacaucccgauggugcagccgcuauuaaagguucguunnuucaacgauuaaaguccuacgugaucugaguucagaccggaguaauccaggucgguuucuaucuacuuucaaauuccucccuguacgaaaggacaagagaaauaaggccuacuucacaaagcgccuucccccguaaaugauaucaucucaacuuaguauuauacccacacccacccaagaacaggguuugu <<<.......<<<<.....................................<......>...............<<.....>>.............>>.>>.............<<....>>......................>>>...........<<<.......>>>...<.<........>.>.<<<<<<.........<<<.<<..<<....>>...>>.>>>...<<.<...<<<<.<.....<<<<<.<<<..<<<.....>>>...<<<..<<<<........>>>>.>>>....>>>.>>>>>...<<.......>>......>.>>>>......>.>>..<<<<<<....<<<<....>>>><<<.<<<<<<<<<<.....<<..........>>.....>>>>>>>>>>..>>>.<<<<<<<<<<......>>>>>>>>>>.<.<<<......>>>.>..<<<.<<<...<..............<....<<<.........>>>....>.......<<<......>>>....................................>...>>>>>>........>>>>>>...<<<<<......>>>>>.........>>>>>><......<<..<<<....>>><<<<..<<<<........<<<<<.<<.....>>.>>>>>......<<<...<<<<.......................>>>>.......>>>.....<<......>>.>>>>.....>>>>..<<<<...<<<<<<<<.<<.........<......<<<<<<..<<<.........>>>...<<<<<<.............>>>>>>....<<<.<<<..<<<<<....>>>..>>>>><<<<<<......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>....>>.>>>>.....>..>>.>>>>>>>>>>>>.>>.....>.....<<<<<........>>>>>.......<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<...............<<<....>>>................>>>>>>>>>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<.....<<<..<<<<.....>>>>..>>>...........>>.........<<<....>>>............>>>>..>>>>>>.......<<<..<.<<<<<<...<<.......>>...>>>>>>...>.>>.>.......<<<<<.<<<<<<..<<.<<<<<<......>>>>>>...>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>...<.<<<.<<<.................>>>.>>><<<<<...<<<....>>>.>>>>>......<<<................>>>......>..........<<<<.......>>>>.... ((.....(..((((.....................................(...[..).........(.....((.]...))....)........)).)).............((....))....)..................)).........(.(((.......))).[.(.(........).).((((((.........(((.((..((....))...)).)))...((.(...((((.(.....(((((.((((.(((....[)))...(((..((((.......{)))).)))..).))).))))).(.((.......))...)..).))))......).))..((((((....((((....)))).((.((((((((((.....((..........)).....))))))))))..))..((((((((((......))))))))))...(((......)))....(((.(((...(..............(.(..(((.........)))..).)....(..(((......))))...................................)...))))))........))))))...(((((......))))).........))))))(......((..(((....)))(((...((((......(.(((((.((.....)).)))))......(((...((((...............(..)....)))).......))).)...((......)).))))......)))..((((....(((((((.((..(....(........((((((.].((.........))....((((((.............))))))....(((.(((..(((((....)))..)))))(((((........)))))........((..........(((((.......)))))..)..)....)))....)).))))....)..))).))))))).)))).)).....)).{..(((((.....]}.))))).......((..(((.((......((((.((((((..(((((.((((((((...............(((....)))................)))))))))))))..(((......[)))((((((..........]))))))(.((.....((...(((....[..)))...))...........)).........(((....))).....)].....))))..))))))......((((..(.((((((.(.((.......)))..))))))...).)).).)......(.((.((((((..((.((((((......))))))...)).(((((.....))))).....)))))..)...))..).....(((((((....))).))))..}.))..))).)).....(((.(((......(....).....))).)))(((((...(((....))).)))))......(((................)))................(((((.......))))..). Human mitochondrial ribosome in complex with mRNA, A/P- and P/E-tRNAs at 2.98 A resolution; 16S mitochondrial rRNA 7qiw 2 3098 2.35 RF02540,RF02543 URS00021745CD_4081 35643637 0003735 0005840 4081 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........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<.......<.....>......>>>>>..[[[..<.<......<<<<<<<<<...>>>>>>>>>......>.>...<<<<<<<<.<<<.<<<<<<<.<<<<<<.<....<<<<......>>>>.((......<<<.....))>>>...>.>>>>>>...>>>>>>>.....>>>>>>>>.>>>.......<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<<<<<......<<<<<<<<<<<<..<<<<<.<<<<..>>>>.>>>>>....>>>>.>>>>>>>>.<.<<<<<<..<<<<<<<<<<<<<<<.....<<<<<<<.........>>>>>.>>...>>>>>>>>>>>>>>>.........<<<<<<<<<<...>>>..<<....>>....>>>>>>>.....>>>>>>.>....>>>.>>>>>>>>>..<<<<........>>>><<<<<<...<<<<<<<.<<<<<<..<<<..<<<<........>>>>...>>>...<<....>>....<<<<<...<<<<....>>>>....>>>>>.<<<<<<<....<<....>>....>>.>>>.>>....>>>>>>.>>>>>>>.<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<......<<.<<<<<<<.....<<<....<<<..<.<<<..<<<<<..>>>>>>>>.>..>>>..>.>>.....>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>..>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.......<..........<<<.<<<<<<.<<<.......<<....>>...>>>.>>>>>>>>>..........))).>....>>>>>>.>>>...>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<<<<.......<<<.<<<<....>>>>>>>....>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<.>>>>>.....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<<...<<<....>>>...<...<<<<<<...<<<<.<<<<<<<.<<<<<.<<<<.......>>>>.><...<<<<<.....<<<<<<....<<<<...>>>>....>>>>>>.....>>>>>....><<<<<<<..>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>...>......>>>>.>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<...............>>>>><<.<<<<<<<<<<<..>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<....>>>>......>>>>>>>...<<..<<<..<<<<<<...<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<.<<<...<<<<<<<<<..>>>>>>>>>...<<<<<.....<<<<...................<<<<<<<...>>>>>>>..>>>>..>>>>>......>>>.>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<<<.<<<<<......>>>>>...>>>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<..<<<<...<<<<<.................>>>>>..<<<<<...<<<<....<<<<<<<<<......>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>...>>>>>>>....<<<<<<<<<.<<.....<<.......<<<<<..>>>>>....>>...........<<<...<<<<<<<<<<<......>>>>>>>>>>>.>>>..................>>.>>>>>>>>>.<<<<<.<.............>...<<<<<<<<<.<<<....<<<<.<..<<<<<.>>>>>..>>>>>...>>>....>>>>..>>>>>...>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((.......(.]...)......))))...((((.........((((((((((...)))))))))....)........((((((..(((.(((((((.((((((.(..({((((......)))))[[(...).(((....}]])))...).))))))...))))))).....))).)))).))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((.(....).))............).....................((.(((((((((..(...((((((((((((..(.(((.((((..)))).))).)....)))).)))))))).(.(((((((.(((((((((((((((.....(((((((.........))))).))...))))))))))))))).........((((((((((...)))(.((....))..).)))))))....))))))).)...)))).)))))).)).[((((........))))((((((..(.((((((.((((((..(((...(((........)))....)))...((....))....(((((...((((....))))....))))).(((((((....((....))....)).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.(........<.))).)))..).))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((((((((((......((.(((((.(......((.....((..(.(((..(((((())))))))).)..))...)).......).)))...(((((((((.(......))))))))))....))))..)))))))).))..((((....((.....))....))))....(((......)))...(((((((...((([[[...(.((((((.......(..........(((.((((((.((........((.().))....)).)))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((((.......(((.((((....)))))))....))))))))))..).....))))))((.....((.....((((.(.......).))))((((.....((((..((...((((((...((.....)).))))))....[[(((.((...(((.(((((....)))..).)...(((((.)))))...).))....))...(((((........)))))]]((((.((((((((..((((....)))...(..<((((((...((((.(((((((((((((.((((...{{..)))).)(...((((((....(((((.....(((.....))).....)))))...).)))))....)(((((((..))))))))))).).))))))).))))(...)....))))))...)).....)))).)))))))).)))..)).....((......)).)))).((((.....))))..))))..(((......(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((..)))))..)))))).))(...).......(((((((((.].(...........)...(((((((....((((....))))......))))))).}.(.(.(((..((((((.(.((......(((......)))......)))))))..)))))(.(.(.........).).)........((..........(((((.......)))))..)..)....).)....)).))))))).)..))).)))))))...)))))....)).{..(((((.....]}.))))).....((((..(((.((......((((.(((((...(((((.(((.(((...(((((((((())))))))))....((((.....((((...............>...((((((.....))))))..))))..)))).......))).)))..)))))..(((......[)).)((((((..........]))))))([((....((((((.(.((((((.......))))))...).((]..[[[))....))))))..(.(((..((((....{..))))..))))((......)).))]]].......((((((..((((.]]]]]]))))))))))....)}.....)))..)))))).......(....(.((((.(...((.......))...).))))...)....)........((((.((((((..(((.(.(((......))).)...))).(((.(.....).))).....)))))..)...))).)......((((((....))).)))...>.))..))).)))).....(((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.............))))...)))).))))...)))))))....(((((((((.(((..(.((.......(((((())))))....)))..........(((...(((((((((((......))))))))))).)))...............)..)).))))))))).(((((.(..(.......)..)...(((((((((.(((....((((.(..(((((.)))))..)))))...)))....))))..)))))...))))).. Specific features and methylation sites of a plant ribosome. 60S ribosomal subunit.; 25S rRNA 7qiw 5 120 2.35 RF00001 URS0000EFFACA_4081 35643637 0003735 0005840 4081 ggaugcgaucauaccagcacuaacgcaccggaucccaucagaacuccgaaguuaagcgugcuugggcgagaguaguacuaggaugggugacccccugggaaguccucguguugcaucccu <<<<<<<<<....<<<<<<<......<<<<<..............>>>..>>.....>>>>>.>><<<<<.<.....<<<<<..<<....>>.>>>>>....>.>>>>>>>>>>>>>>.. (((((((((....(((((((......((((((...(....)...))))..)).....))))).))(((((.......(((((..((....)).)))))......)))))))))))))).. Specific features and methylation sites of a plant ribosome. 60S ribosomal subunit.; 5S rRNA 7qiw 8 159 2.35 RF00002 URS00023359E6_4081 35643637 0003735 0005840 4081 aacgacucucggcaacggauaucucggcucucgcaucgaugaagnacguagcgaaaugcgauacuuggugugaauuncagaaucccgugaaccaucgagucuuugaacgcaaguugcgcccgaagccauggccgagggcacgucugccugggcgucacg ...........................................<<<<<<.((.....>>>.....<<<<<......))..............>>>>.>...>>>....<<.....>><<<<...<<<..>>>...>>>>.................... ...........................................((((((.[[.....))).....(((((......]]..............)))).)...)))....((.....))((((...(((())))...)))).................... Specific features and methylation sites of a plant ribosome. 60S ribosomal subunit.; 5.8S rRNA 7qiy 2 474 2.58 RF01960,RF01959,RF00177 URS00023359C7_4081 35643637 0003735 0005840 4081 uugacggaagggcaccaccaggaguggagccugcggcuuaauuugacncaacacggggaaacuuaccagguncagacauaguagacugagagcucuuucnanggguggngnugcauggcnguucuuaguugguauuugucugguuaauuccguuaacgancgagaccucagccugcuaacuagcuaugcggagguucccuucgcggccagcuncuuagagggacuacggccuuuuaggccgcggaaguuugaggcaauaacangucugugaugcccnuagauguucugggccgcacgcgcgcuacacugauguauucaacgagcuuauagccuuggccgacaggcccggguaaucuuugaaauuucaucgugauggggauagaucauugcaauuguuggucuucaacgngnaauuccuaguaagcgcgagucaucagcucgcguugacuacgucccugcccuuuguacacaccg .<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<........<<........>>..........<<<<<......<<<<<.<<........>>....>>>>>...<<.<<<..<<.<<<<<<....<<<.<<.......<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<.<<<<<<<<...>>>>>>>>...>>>>..>>>>.>>.....<<<<<.....>>>>>........>>>>>....>>>.>>>.....>>>>>>>.......>>>>>......>>>>.>>>.....<<<<.<.......<<.......<<<.<<<<....>>>>.>>>....>>.......>.>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>..... .((((..(((((((..((..(((((..(((..(((((.......(........)...........(((((.(....(((((.((........))....)))))...((.(((...(.((((((....((..((......(.((......)))...))..))....(((((.((..((((..(((..((((((((...))))))))....)))..)))).))..(..(((((.....))))).....)..)))))....))).))).....).))))).....).)))))...)).)))..))).(...(.((.(.......((.......(((.((((....)))).)))....)).......).)).)......(....(((((............)))))....)..)..))))).....((((((((.......))))))))......))...))))))).)).))..... Specific features and methylation sites of a plant ribosome. 40S head ribosomal subunit.; 18S rRNA head 7qiy Q 14 2.58 URS00023359B6_4081 35643637 4081 aggcugauaaccua <<<.......>>>. (((.......))). Specific features and methylation sites of a plant ribosome. 40S head ribosomal subunit.; tRNA 7qiz 2 3098 2.38 RF02543 URS00021745CD_4081 35643637 0003735 0005840 4081 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........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<.......<.....>......>>>>>..[[[..<.<......<<<<<<<<<...>>>>>>>>>......>.>...<<<<<<<<.<<<.<<<<<<<.<<<<<<.<....<<<<......>>>>.((......<<<.....))>>>...>.>>>>>>...>>>>>>>.....>>>>>>>>.>>>.......<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<<<<<......<<<<<<<<<<<<..<<<<<.<<<<..>>>>.>>>>>....>>>>.>>>>>>>>.<.<<<<<<..<<<<<<<<<<<<<<<.....<<<<<<<.........>>>>>.>>...>>>>>>>>>>>>>>>.........<<<<<<<<<<...>>>..<<....>>....>>>>>>>.....>>>>>>.>....>>>.>>>>>>>>>..<<<<........>>>><<<<<<...<<<<<<<.<<<<<<..<<<..<<<<........>>>>...>>>...<<....>>....<<<<<...<<<<....>>>>....>>>>>.<<<<<<<....<<....>>....>>.>>>.>>....>>>>>>.>>>>>>>.<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<......<<.<<<<<<<.....<<<....<<<..<.<<<..<<<<<..>>>>>>>>.>..>>>..>.>>.....>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>..>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.......<..........<<<.<<<<<<.<<<.......<<....>>...>>>.>>>>>>>>>..........))).>....>>>>>>.>>>...>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<<<<.......<<<.<<<<....>>>>>>>....>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<.>>>>>.....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<<...<<<....>>>...<...<<<<<<...<<<<.<<<<<<<.<<<<<.<<<<.......>>>>.><...<<<<<.....<<<<<<....<<<<...>>>>....>>>>>>.....>>>>>....><<<<<<<..>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>...>......>>>>.>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<...............>>>>><<.<<<<<<<<<<<..>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<....>>>>......>>>>>>>...<<..<<<..<<<<<<...<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<.<<<...<<<<<<<<<..>>>>>>>>>...<<<<<.....<<<<...................<<<<<<<...>>>>>>>..>>>>..>>>>>......>>>.>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<<<.<<<<<......>>>>>...>>>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<..<<<<...<<<<<.................>>>>>..<<<<<...<<<<....<<<<<<<<<......>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>...>>>>>>>....<<<<<<<<<.<<.....<<.......<<<<<..>>>>>....>>...........<<<...<<<<<<<<<<<......>>>>>>>>>>>.>>>..................>>.>>>>>>>>>.<<<<<.<.............>...<<<<<<<<<.<<<....<<<<.<..<<<<<.>>>>>..>>>>>...>>>....>>>>..>>>>>...>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((.......(.]...)......))))...((((.........((((((((((...)))))))))....)........((((((..(((.(((((((.((((((.(..({((((......)))))[[(...).(((....}]])))...).))))))...))))))).....))).)))).))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((.(....).))............).....................((.(((((((((..(...((((((((((((..(.(((.((((..)))).))).)....)))).)))))))).(.(((((((.(((((((((((((((.....(((((((.........))))).))...))))))))))))))).........((((((((((...)))(.((....))..).)))))))....))))))).)...)))).)))))).)).[((((........))))((((((....((((((.((((((..(((...(((........)))....)))...((....))....(((((...((((....))))....))))).(((((((....((....))....)).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.(........<.))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((......((.(((((.(......((.....((..(.(((..(((((())))))))).)..))...)).......).)))...(((((((((.(......))))))))))....))))..)))))))).))..((((....((.....))....))))....(((......)))...(((((((...((([[[...(.((((((.......(..........(((.((((((.((........((.().))....)).)))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((((.......(((.((((....)))))))....))))))))))..).....))))))((.....((.....((((.(.......).))))((((.....((((..((...((((((...((.....)).))))))....[[(((.((...(((.(((((....)))..).)...(((((.)))))...).))....))...(((((........)))))]]((((.((((((((..((((....)))...(..<((((((...((((.(((((((((((((.((((...{{..)))).)(...((((((....(((((.....(((.....))).....)))))...).)))))....)(((((((..))))))))))).).))))))).))))(...)....))))))...)).....)))).)))))))).)))..)).....((......)).)))).((((.....))))..))))..(((......(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((..)))))..)))))).))(...).......(((((((((.].(...........)...(((((((....((((....))))......))))))).}.(.(.(((..((((((.(.((......(((......)))......)))))))..)))))(.(.(.........).).)........((..........(((((.......)))))..)..)....).)....)).))))))).)..))).)))))))...)))))....)).{..(((((.....]}.))))).....((((..(((.((......((((.(((((...(((((.(((.(((...(((((((((())))))))))....((((.....((((...............>...((((((.....))))))..))))..)))).......))).)))..)))))..(((......[)).)((((((..........]))))))([((....((((((.(.((((((.......))))))...).((]..[[[))....))))))..(.(((..((((....{..))))..))))((......)).))]]].......((((((..((((.]]]]]]))))))))))....)}.....)))..)))))).......(....(.((((.(...((.......))...).))))...)....)........((((.((((((..(((.(.(((......))).)...))).(((.(.....).))).....)))))..)...))).)......((((((....))).)))...>.))..))).)))).....(((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.............))))...)))).))))...)))))))....(((((((((.(((..(.((.......(((((())))))....)))..........(((...(((((((((((......))))))))))).)))...............)..)).))))))))).(((((.(..(.......)..)...(((((((((.(((....((((.(..(((((.)))))..)))))...)))....))))..)))))...))))).. Specific features and methylation sites of a plant 80S ribosome; 25S rRNA 7qiz 5 120 2.38 RF00001 URS0000EFFACA_4081 35643637 0003735 0005840 4081 ggaugcgaucauaccagcacuaacgcaccggaucccaucagaacuccgaaguuaagcgugcuugggcgagaguaguacuaggaugggugacccccugggaaguccucguguugcaucccu <<<<<<<<<....<<<<<<<......<<<<<..............>>>..>>.....>>>>>.>><<<<<.<.....<<<<<..<<....>>.>>>>>....>.>>>>>>>>>>>>>>.. (((((((((....(((((((......((((((...(....)...))))..)).....))))).))(((((.......(((((..((....)).)))))......)))))))))))))).. Specific features and methylation sites of a plant 80S ribosome; 5S rRNA 7qiz 8 159 2.38 RF00002 URS00023359E6_4081 35643637 0003735 0005840 4081 aacgacucucggcaacggauaucucggcucucgcaucgaugaagnacguagcgaaaugcgauacuuggugugaauuncagaaucccgugaaccaucgagucuuugaacgcaaguugcgcccgaagccauggccgagggcacgucugccugggcgucacg ...........................................<<<<<<.((.....>>>.....<<<<<......))..............>>>>.>...>>>....<<.....>><<<<...<<<..>>>...>>>>.................... ...........................................((((((.[[.....))).....(((((......]]..............)))).)...)))....((.....))((((...(((())))...)))).................... Specific features and methylation sites of a plant 80S ribosome; 5.8S rRNA 7qiz S2 1584 2.38 RF01960,RF02542,RF01959,RF00177 URS0002349D61_4081 35643637 0003735 0005840 4081 uaccugguugauccugccaguagucaunugcuugucunaaagauuaagccaugcauguguaaguaugaacaaauagacugugaaacugcgaauggcucauuaaaucaguuauaguuuguungaugguuacunggauaaccguaguaauucuagngcuaauacgugcaccccgaaagggaugcauuuauuagauagcnaugauucaugauaacucgacggaucgcacggccgccggcgacgcaucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguggugacgggugacggagaauuaggguucgauuccggaganggagccugagaaacggcuaccacauncaaggaaggcagcaggcgcgcnaauuacccaauccugacacggggaggunguganaauaaauaacaauaccgggagucugguaauuggaaugaguacaaucuaaaucccuuaacgaggnuccauuggagggcaagucuggugccagcagccgcggnaauuccagcuccaauancguanauuuaaguugnugcaguunaaaagcucguaguuggacuuuguguuacuuugaagaaauuagagugcucaaagcaagccuacgcucuguauacauungcaugggauaacauuauaggauuucgguccuaugggaucggaguaaugauuaacagggacagucgggggcauucguauuucauagucagaggugaaauucuuggauuuaugaaagacgaacaacugcgaaagcauuugccaaggauguuuucauuaaucaagancgaaaguugggggcucgaagacgaucagauaccgnccuagucucaaccauaaacgaugccgaccagggaucggcggauguugcuaggacuccgccggcaccuuaugagaaaucaaaguuuuuggguuccggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacncaacacggggaaacuuaccagguncagacauaguagacugagagcucuuucnanggguggngnugcauggcnguucuuaguugguggagcgauuugucugguuaauuccguuaacgancgagaccucagccugcuaacuagcuaugcggagguucccuucgcggccagcuncuuagagggacuacggccuuuuaggccgcggaaguuugaggcaauaacangucugugaugcccnuagauguucugggccgcacgcgcgcuacacugauguauucaacgagcuuauagccuuggccgacaggcccggguaaucuuugaaauuucaucgugauggggauagaucauugcaauuguuggucuucaacgngnaauuccuaguaagcgcgagucaucagcucgcguugacuacgucccugcccuuuguacacaccgnccgucgcuccuaccgauugaaugauccggugaaauguucggaucgcggucgcgagaaguccauugaaccuuaucauuuagagganggagaagucguancaagguuucnguaggugnnccugcggaaggaucauug ...<<<<<.[.((((>>>>>.<<<.<<<<<<...<.<...<......<<<.<<<..<<....<<....<<.........>>...>>.>>......<<........<<<..<<..<<....<<<<<......<<.....<..<<<.....>>>..>......>>.....<<<....>>>......<<<<<<...............>>>>>>.........<<<<.<<<<.>>>>>>>>..>>>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>..>>>..>....>.>.....<<<<<<<<<<..>>>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>..........<.<((.....<.<<...<<<.<<......<<<<<<.<<.......<<...<.......>..<<<....>>>.....>>......>>.>>..>>>>........<<<<<<<<<<<..>>>>>>>>>>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<.<<>>>>>>>>>>>>>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<........<<........>>..........<<<<<......<<<<<.<<........>>....>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<......>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<.<<<<<<<<...>>>>>>>>...>>>>..>>>>.>>.....<<<<<.....>>>>>........>>>>>....>>>.>>>.....>>>>>>>.......>>>>>......>>>>.>>>.....<<<<.<.......<<.......<<<.<<<<....>>>>.>>>....>>.......>.>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<<.<<....<<<<<<<..<<<..<<<<..<...<<<<<..>>>>>...>..>>>>..>>>..>>>>>>>...>>.>>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..)))).(.(..(((((...(.(...((.....(((.(((..((....((....((.........))...))[))......(((.......(((...(..((....(((((..[...((.....(..(((.....)))..)......)).....(((....)))..(((.((..(.......(......)..)..)).).).).(]((((..(((.))).))))).)))))...)))...))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((....(((.]...)))..)))).)....).).....((((((((((..))))))).)))....(.(.(.(...........))..)......)..((((([[....(.((((.....((..]])).......))))))))))..))))).).)...[......(.([[...(.(.((...(.(..(......(((.((.((.......((..((.......)).(((....))).....))......)).))...)))........(((((((((((..))))))))))).....)....(((..((.((...(((...(((.(((((((....(..........).......))))))).))).......((....))....)))..)).))...))..)).)...)).)....((((((....(...((((.........))))...).))))))......{....((.((.(((..((((((((.(((.(..))))))))))))..)))...((..]]))...))...].)).)).).(((......((((....))))....)))...]]].]((((..(((((((..((..(((((..(((..(((((.......(........)...........(((((.(....(((((.((........))....)))))...((.(((...(.((((((.(..((..((((......))..(.((......)))...))..))....(((((.((..((((..(((..((((((((...))))))))....)))..)))).))..(..(((((.....))))).....)..))))).)..))).))).....).))))).....).)))))...)).)))..))).(...(.((.(.......((.......(((.((((....)))).)))....)).......).)).)......(....(((((............)))))....)..)..))))).....((((((((.......))))))))......))...))))))).)).))..(.(..((.(.(((((.((..(.(((((((..(((..((((..(...(((((..)))))...)..))))..)))..))))))))..)).)))))..).))...)..)..(((((((((....)))))))))}........ Specific features and methylation sites of a plant 80S ribosome; 18S 7qiz aA 14 2.38 URS00023359B6_4081 35643637 4081 aggcugauaaccua <<<.......>>>. (((.......))). Specific features and methylation sites of a plant 80S ribosome; tRNA_1 7qp6 7 20 4.7 35489072 9606 aaaaaaaaaaaaaaaaaaaa .................... .................... Structure of the human 48S initiation complex in open state (h48S AUG open); mRNA 7qp6 A 1719 4.7 RF01960,RF01959,RF00177 URS0000726FAB_9606 35489072 0003735 0005840 9606 uaccugguugauccugccaguagcaunugcuugucucaaagauuaagccaugcaugucugaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuauggunccuunggucgcucgcuccuacuuggauaacugugguanuucuagngcuaauanaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgccccccguggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcnaauuacccacucccgacccgggganguagugangaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauancguauauuaaaguugcugcaguunaaaagcucguaguungaucuugggagcggccccgccccucucggcggcccgaagcguuuacuuugaaaaaanuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagancgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauucngauaacgaacgagacucuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauunagucccugcccuuuguacacaccgnccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccgggggcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucgnaacaagguuuccguaggugnnccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<.........<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<....<<....<<<<<.............<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<........>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<<......>>>>>>>>.>>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>......>>.>.....<.<<...<<..<<....>>..>>.....>>..>.....<<..<...........>..>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<....<<<..........>>><<.............>>...<<<<<<.<.......<<...<.......>.<<<<.......>>>>...>>......>.>>>..>>>........<.<<.<<<.<.<...............>>..>>>.>>.>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<........>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<......>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<......<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<.......>>>>.>>>>.....>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.......>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>..........<.<<<<<..........>>>>>>..........>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<.......................>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..((....(((.....((....[...((.....((.(((.....))).))......))......)).((((...((((........))))...))))((..(((((...(......)..)))))......)).(]((((.((((......)))))))))...)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).).....(......((.(((....))).))........)....(.((..(...........)..))......)..((((([[....(.((((.....((..]])).......))))))))))..)))))).)))..[......(.([[...(.(.((...(((..(.....((..........)).((.............))...((((((.(.......((..((.......)).(((.......)))....))......).)))..)))........(.((.(.(...(...............)...).).)).)....)....(((.((...(...((((..((..((((((((...((........))......))))))))..)).......((....))...))))..)...))..))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.(((........))))))))).)..)))...((..]]))...))...].))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.(((.((......((........))..........(((((.(....(((((.....(..((.(((........)))).)....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((...(...((((..((((((((((((.......)))).)))).....))))..))))..).....(((((.....)))))........)))....))).))).....).))))).....).)))))...))..))).))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..((((.((...((((.(......................)))))...)).))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}........ Structure of the human 48S initiation complex in open state (h48S AUG open); 18S rRNA 7qp6 w 75 4.7 RF00005 URS0000326EAC_9606 35489072 0030533 0006412 9606 agcagaguggcgcagcggaagcgugcugggcccauaacccagaggucgauggaucgaaaccauccucugcuacca .<<<<<...<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>.>>>>>..... .((((((...(((.......)))..(((((.......))))).....(((((.......)))))))))))..... Structure of the human 48S initiation complex in open state (h48S AUG open); Initiator Met-tRNA-i 7qp7 7 21 3.7 35489072 9606 agaccaccaugguacguuuca ..................... ..................... Structure of the human 48S initiation complex in closed state (h48S AUG closed); mRNA 7qp7 A 1719 3.7 RF01960,RF01959,RF00177 URS0000726FAB_9606 35489072 0003735 0005840 9606 uaccugguugauccugccaguagcaunugcuugucucaaagauuaagccaugcaugucugaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuauggunccuunggucgcucgcuccuacuuggauaacugugguanuucuagngcuaauanaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgccccccguggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcnaauuacccacucccgacccgggganguagugangaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauancguauauuaaaguugcugcaguunaaaagcucguaguungaucuugggagcggccccgccccucucggcggcccgaagcguuuacuuugaaaaaanuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagancgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauucngauaacgaacgagacucuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauunagucccugcccuuuguacacaccgnccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccgggggcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucgnaacaagguuuccguaggugnnccugcggaaggaucauua 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...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..((....(((.....((....[...((.....((.(((.....))).))......))......)).((((...((((........))))...))))((..(((((...(......)..)))))......)).(]((((.((((......)))))))))...)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).).....(......((.(((....))).))........)....(.((..(...........)..))......)..((((([[....(.(.((.....((..]])).......)).)))))))..)))))).)))..[......(.([[...(.(.((...(((..(....(((..........))).(.............)....((((((.(.......((..((.......)).(((.......)))....))......).)))..)))........(.((.(.(...(...............)...).).)).)....)....(((.((...(...((((..((..((((((((...((........))......))))))))..)).......((....))...))))..)...))..))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.(((........))))))))).)..)))...((..]]))...))...].))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((...(...((((..((((((((((((.......)))).)))).....))))..))))..).....(((((.....)))))........)))....))).))).....).))))).....).)))))...)).)))).))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..((((.((...(((((.......................)))))...)).))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}........ Structure of the human 48S initiation complex in closed state (h48S AUG closed); 18S rRNA 7qp7 w 75 3.7 RF00005 URS0000326EAC_9606 35489072 0030533 0006412 9606 agcagaguggcgcagcggaagcgugcugggcccauaacccagaggucgauggaucgaaaccauccucugcuacca .<<<<<....<<<.......>>>..<<<<<.......>>>>>.....<<<<<.......>>>>>.>>>>>..... .((((((....((.......))...(((((.......))))).....((.((.......)).))))))))..... Structure of the human 48S initiation complex in closed state (h48S AUG closed); Initiator Met-tRNA-i 7qq3 I 2898 2.1 RF02541 URS00004B0F34_83333 36603206 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccuu 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((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((((...))).))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((...(......{.(((((.(((..(((.........)))..))).....(..(((......)))).)))))....)...))))).))...........]]].)...))))))))))...)))))))(((((((........)))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((.(......).(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((...(...............((((...((......((((((((....))))))))...)).............))))......)..).))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).).....((.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..))....(.(((((....))).)).)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))).. Cryo-EM structure of the E.coli 50S ribosomal subunit in complex with the antibiotic Myxovalargin A.; 23S ribosomal RNA 7qq3 J 118 2.1 RF00001 URS00002150CD_83333 36603206 0003735 0005840 83333 gccuggcggcaguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccucaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......(((((.((...)).))))).......))...))))))))). Cryo-EM structure of the E.coli 50S ribosomal subunit in complex with the antibiotic Myxovalargin A.; 5S ribosomal RNA 7qr3 C 69 2.18 RF00622 URS0002617738_9598 3.1.-.- 0004540 9598 gggggccacagcagaagcguucacgucgcggccccugucagccauugcacuccggcugcgaauucugcu <<<<<<<..(((((((<<<.......>>>>>>>>>>..<<<<<..........>>>>>....))))))) (((((((..[[[[[[[(((.......))))))))))..(((((..........)))))....]]]]]]] Chimpanzee CPEB3 HDV-like ribozyme; chimpanzee CPEB3 ribozyme 7qr3 D 69 2.18 RF00622 URS0002617738_9598 3.1.-.- 0004540 9598 gggggccacagcagaagcguucacgucgcggccccugucagccauugcacuccggcugcgaauucugcu <<<<<<<..((((((.<<<.......>>>>>>>>>>..<<<<<..........>>>>>.....)))))) (((((((..[[[[[..(((.......))))))))))..(((((..........)))))......]]]]] Chimpanzee CPEB3 HDV-like ribozyme; chimpanzee CPEB3 ribozyme 7qr4 B 69 2.83 RF00622 URS0002617729_9606 3.1.-.- 0004540 9606 gggggccacagcagaagcguucacgucgcagccccugucagccauugcacuccggcugcgaauucugcu ((((((...<<<<<<<<<<.......>>>.))))))..<<<<<..........>>>>>....>>>>>>> [[[[[[...((((((((((.......))).]]]]]]..(((((..........)))))....))))))) human CPEB3 HDV-like ribozyme; RNA CPEB3 ribozyme 7qtl R 14 2.48 URS0000EEAD16_11320 36596301 11320 ucugcuucugcuau .............. .............. Influenza A/H7N9 polymerase elongation complex; 3' vRNA 7qtl M 17 2.48 36596301 11320 aucuauaauagcagaag ................. ................. Influenza A/H7N9 polymerase elongation complex; mRNA 7qtn A 14 1.2 URS000268137A_32630 35687141 32630 gguayugcgnuacc .............. .............. Duplex RNA containing Xanthosine-Cytosine base pairs; RNA (5'-R(*GP*GP*UP*AP*(RY)P*UP*GP*CP*GP*(XAN)P*UP*AP*CP*C)-3') 7qtn B 14 1.2 URS0002681374_32630 35687141 32630 gguacugcgnuacc .............. .............. Duplex RNA containing Xanthosine-Cytosine base pairs; RNA (5'-R(*GP*GP*UP*AP*CP*UP*GP*CP*GP*(XAM)P*UP*AP*CP*C)-3') 7qtt d 93 3.1 RF00026 URS000035C796_9606 37165190 0030621 0000244,0000353 0005688,0046540 9606 gugcucgcuucggcagcacauauacuaaaauuggaacgauacagagaagauuagcauggccccugcgcaaggaugacacgcucgugaagcguu <<<<<.<<<..>>>>>>>>.....................................<<...<<<.....>>>....>>............... (((((.((....))))))).....................................((..((((.....)))..).))............... Structural organization of a late activated human spliceosome (Baqr, core region); U6snRNA 7qtt e 98 3.1 RF00020 URS000075BAAE_9606 37165190 0000244,0000353 0005682,0046540 9606 gguuucucuucagaucgcauaaaucuuucgccuuuuacuaaagauuuccguggagaggaacaaucugagauuuuuugaggccuugcuuuggcaaggcu .<<<<<<<<<<<........<<<<<<<<...........>>>>>>>>...>>>>>>>>>>>.................<<<<<<<<....>>>>>>>> .((((((((((....((...((((((((.(.......).)))))))).)).)))))))))).................((.(((((....)))).))) Structural organization of a late activated human spliceosome (Baqr, core region); U5 snRNA 7qtt f 76 3.1 RF00004 URS00003EE995_9606 37165190 0045131 0000348 0005686 9606 aucgcuucucggccuggcuaagaucaaguguaguaucuguucuuaucaguuuaauaucugauguccucucgaggac .............................................<<<<........>>>>...<<<<..>>>>.. .............................................(((..........)))...((((..)))).. Structural organization of a late activated human spliceosome (Baqr, core region); U2snRNA 7qtt g 76 3.1 URS00026813FC_10535 37165190 10535 ucggccuccgaacgguaagagccuagcauguagaacugguuaugaugucauacuuauccugucccuuuuuuuucca ............................................................................ ............................................................................ Structural organization of a late activated human spliceosome (Baqr, core region); MINX 7qua A 12 1.0 URS000268136B_32630 35687141 32630 cgcgnauuagcg ............ ............ Duplex RNA containing Xanthosine-Cytosine base pairs; RNA (5'-R(*CP*GP*CP*GP*(XAN)P*AP*UP*UP*AP*GP*CP*G)-3') 7qv1 B 112 3.5 RF00001 URS0000BC467F_224308 35264791 0003735 0005840 224308 ugguggcgauagcgaagaggucacacccguucccauaccgaacacggaaguuaagcucuucagcgccgaugguagucggggguuucccccugugagaguaggacgccgccaa <<<<<<<....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<.......<<.<<<<<...>>>>>.>>.......>>..>>>>>>>. (((((((....((((((((.....((((((...(.....)...))))..))....)))))).)).((.......((.(((((...))))).)).......))..))))))). Bacillus subtilis collided disome (Leading 70S); 5S ribosomal RNA 7qv1 H 77 3.5 RF00005 URS00002C7A07_224308 35264791 0030533 0006412 224308 gguccgguaguucaguugguuagaaugccugccugucacgcaggaggucgcggguucgagucccguccggaccgcca <<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.........)))).(((((.......))))).....(((((.......)))))))))))).... Bacillus subtilis collided disome (Leading 70S); P-site tRNA 7qv1 V 2887 3.5 RF02540,RF02541,RF00002 URS0002335902_224308 35264791 0003735 0005840 224308 guuaaguuagaaagggcgcacgguggaugccuuggcacuaggagccgaugaaggacgggacgaacaccgauaugcuucggggagcuguaagcaagcuuugauccggagauuuccgaauggggaaacccaccacucguaauggagugguauccauaucugaauucauaggauaugagaaggcagacccggggaacugaaacaucuaaguacccggaggaagagaaagcaaaugcgauucccugaguagcggcgagcgaaacgggaucagcccaaaccaagaggcuugccucuugggguuguaggacacucgaacgagguagaugaagaggucuggaaaggcccgccauaggagguaacagcccuguagucaaaacuucguucgaguggauccugaguacggcggaacacgugaaauuccgucggaauccgggaggaccaucucccaaggcuaaauacucccuagugaccgauagugaaccaguaccgugagggaaaggugaaaagcaccccggaaggggagugaaagagauccugaaaccgugugccuacaaguagucagagcccguuaacgggugauggcgugccuuuuguagaaugaaccggcgaguuacgaucucgugcaagguuaagcagaagaugcggagccgcagcgaaagcgagucugaauagggcgcaugaguacguggucguagacccgaaaccaggugaucuacccauguccagggugaaguucagguaacacugaauggaggcccgaacccacgcacguugaaaagugcggggaugagguguggguaggggugaaaugccaaucgaaccuggagauagcugguucucuccgaaauagcuuuagggcuagccucaagguaagagucuuggagguagagcacugauuggacuaggggccccuaccggguuaccgaauucagucaaacuccgaaugccaaugacuuauccuugggagucagacugcgagugauaagauccguagucgaaagggaaacagcccagaccgccagcuaaggucccaaaguauacguuaaguggaaaaggauguggaguugcuuagacaaccaggauguuggcuuagaagcagccaccauuuaaagagugcguaauagcucacuggucgagugacucugcgccgaaaauguaccggggcuaaacguaucaccgaagcugcggacuguucgaacagugguaggagagcguucuaagggcugugaagccagaccggaaggacugguggagcgcuuagaagugagaaugccgguaugaguagcgaaagaggggugagaauccccuccaccgaaugccuaagguuuccugaggaaggcucguccgcucaggguuagucgggaccuaagccgaggccgaaaggcguaggcgauggacaacagguugauauuccuguaccaccuccucaccauuugagcaauggggggacgcaggaggauaggguaagcgcgguauuggauauccgcguccaagcaguuaggcugggaaauaggcaaauccguuucccaaaggcugagcugugauggcgagcgcgaaguuccugauuccacacugccaagaaaagccucuagcgaggugagaggugcccguaccgcaaaccgacacagguaggcgaggagagaauccuaaggugaucgagagaacucucguuaaggaacucggcaaaaugaccccguaacuucgggagaaggggugcucuguuagggugcaagcccgagagagccgcagugaauaggcccaggcgacuguuuagcaaaaacacaggucucugcgaagccguaaggcgaaguauaggggcugacgccugcccggugcuggaagguuaagaggagcgcuuagcguaagcgaaggugcgaauugaagccccaguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgacccgcacgaaaggcgcaacgaucugggcacugucucaacgagagacucggugaaauuauaguaccugugaagaugcagguuacccgcgacaggacggaaagaccccguggagcuuuacugcagccugauauugaauguugguacagcuuguacaggauagguaggagccuuggaaaccggagcgccagcuucgguggaggcaucggugggauacuacccuggcuguauugaccuucuaacccaccgcccuuaucgggcggggagacagugucaggugggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguucccucagaaugguuggaaaucauucgcagaguguaaaggcacaagggagcuugacugcgagaccuacaagucgagcagggacgaaagucgggcuuagugauccggugguuccgcauggaagggccaucgcucaacggauaaaagcuaccccggggauaacaggcuuaucucccccaagaguccacaucgacggggagguuuggcaccucgaugucggcucaucgcauccuggggcuguagucggucccaaggguugggcuguucgcccauuaaagcgguacgcgagcuggguucagaacgucgugagacaguucggucccuauccgucgcgggcgcaggaaauuugagaggagcuguccuuaguacgagaggaccgggauggacgcaccgcugguguaccaguuguucugccaagggcaucgcuggguagcuaugugcggacgggauaagugcugaaagcaucuaagcaugaagccccccucaagaugagauuucccauuccgcaaggaaguaagaucccugaaagaugaucagguugauaggucugagguggaaguguggcgacacauggagcugacagauacuaaucgaucgaggacuuaacc .<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<..[..((.>>>.....<<<<<<<..<<<))..]..>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<<<<<<<<.........>>>>>>>.>>.>>....<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<......<<.....>>.....>>>>...(((....<<<<<<<<....>>>>>>>>......<<<<<<<<..<<<<<<<<.<<<.....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>..>>>>..>>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<......>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<.<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>......>>>>>.>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>...>.>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<...<<<<<<<<<.....<<<...<<<<<<<<...<<<<.<<.....>>.>>.>>...>>>>>>>>..>>.>.....>>>>.>>>>>..>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>...>>>>>>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<..>>>>>>....>>>>>><.<<<<<<<.<.......<<<<<.<<....>>.>>>>>....>.>>>>>>>..>.....>>>>>><......<<....<<<<<<.......>>>>>><<<<....<<<<<.<<<..<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<.<<<<<<......<<...<<<<....<<<<..<<<..<<<.<<<<<<<<...(((....>>>>>><<..<<<<<..<<<<<<<<<<<.<<.....>>>>>>>>>...>>>>..>>>>>...>><..<..>...>>>>>>...>>>...>>>>.........>>>>..>>..>>>>>>>>>>>>>>>.>>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<.....<<<<....>>>>....>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>..<<<<.<<<..<<<<<<<..<<<...<....<<<<<..<<....>>...>>>>>....>...>>>>>>>>..>>>>><<<<<.........>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>...>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<<.<<<.<<<<<<<<<.<.............<.<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>.>...>..>>>>>>>>>.>>>....<<.<<<<<<.....>>>>>>>>.....>>>>>>>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.)))>>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>.. .((((((......((((((((((.....(((..(((((((((((((......((((((..[..[[[)))...].((((((...(((]]..]..)))......))))))...)))....(((....)))(((((((......))))))).(((((((((.........))))))).)).))....((((((.....(...[..)......))))).).........((....))...((((......((.]...)).....))))...((((...(((((((((..)))))))))....{.(((((((((.((((((((.(((...(.((((......)))))[[(...).(((.....]])))...)))...)))))))).)))))..)))))....((((((((..[......))))))))....}.(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((..((((..[...))))..))))...(.(........).).((((((....(((((((.(((((..((....(((.....)))....))...((....))..((((.....))))......))))).)))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)<)))...(((.(((((.......A))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((...((((((.((.....(((...((((((((...((..(((.....)))...))...))))))))..)).).....)).).)))))..))))))).))..(((((((.((......)).)))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((((.((.....{.(((((.(((...((.........).)..)))..........(......)....)))))...)).))))))).))...........]]].)...))))))))))...)))))))((((((()))))))....))))))(((((((...((......(((((.((....))])))))...))...))))).)).....))))))(......((....((((((.......))))))((((....(((...((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((.((((((......((...((((....((((..(((..(((.((((((((....{{....))))))((..(((((..(((((((((((.((.....)))))))))...))))..)))))...))(..(())...))))))...)))...))))(..).....))))..))..))))))))))))))).))).....((......))..))).((((.....))))..))))...(((....((((((((.((..(....(.......(((((....(.[..).....)))))((((.....((((....))))....))))(...).......(((((((((.>.((.........))...(((((((.....(((....))).......))))))).](((..(((..(((((((..(((...(....(((((..((....))...)))))....)...))))))))..)))))((((...........))))........((..........(((((.......)))))..)..).....)))...)).))))))).)..))).)))))))).))).)).....)).[..(((((......].)))))..((((((((.(((.((......((((.((((((..(((((.(((((((((.((..(..(.((((..............((.((..(((......(((.((((....)))).)))...)))............)).)).....)))).)...).))....(..((((((.....)))))).).....)))))))))..)))))..(((......[)))((((((..........]))))))([((...(((((((...((.((.........)).)).....((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..a.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..((((....))))....(((.(((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))....)))....)))))).. Bacillus subtilis collided disome (Leading 70S); 23S ribosomal RNA 7qv1 a 1533 3.5 RF00177,RF01959,RF01960 URS000197CF6E_224308 35264791 0003735 0005840 224308 ggagaguuugauccuggcucaggacgaacgcuggcggcgugccuaauacaugcaagucgagcggacagaugggagcuugcucccugauguuagcggcggacgggugaguaacacguggguaaccugccuguaagacugggauaacuccgggaaaccggggcuaauaccggaugguuguuugaaccgcaugguucaaacauaaaagguggcuucggcuaccacuuacagauggacccgcggcgcauuagcuaguuggugagguaacggcucaccaaggcgacgaugcguagccgaccugagagggugaucggccacacugggacugagacacggcccagacuccuacgggaggcagcaguagggaaucuuccgcaauggacgaaagucugacggagcaacgccgcgugagugaugaagguuuucggaucguaaagcucuguuguuagggaagaacaagugccguucgaauagggcgguaccuugacgguaccuaaccagaaagccacggcuaacuacgugccagcagccgcgguaauacguagguggcaagcguuguccggaauuauugggcguaaagggcucgcaggcgguuucuuaagucugaugugaaagcccccggcucaaccggggagggucauuggaaacuggggaacuugagugcagaagaggagaguggaauuccacguguagcggugaaaugcguagagauguggaggaacaccaguggcgaaggcgacucucuggucuguaacugacgcugaggagcgaaagcguggggagcgaacaggauuagauacccugguaguccacgccguaaacgaugagugcuaaguguuaggggguuuccgccccuuagugcugcagcuaacgcauuaagcacuccgccuggggaguacggucgcaagacugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggucuugacauccucugacaauccuagagauaggacguccccuucgggggcagagugacagguggugcaugguugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuugaucuuaguugccagcauucaguugggcacucuaaggugacugccggugacaaaccggaggaagguggggaugacgucaaaucaucaugccccuuaugaccugggcuacacacgugcuacaauggacagaacaaagggcagcgaaaccgcgagguuaagccaaucccacaaaucuguucucaguucggaucgcagucugcaacucgacugcgugaagcuggaaucgcuaguaaucgcggaucagcaugccgcggugaauacguucccgggccuuguacacaccgcccgucacaccacgagaguuuguaacacccgaagucggugagguaaccuuuuaggagccagccgccgaaggugggacagaugauuggggugaagucguaacaagguagccguaucggaaggugcggcugg ...<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<<<...<<<<<<..>>>>>>...>>>>.>>>>>......<<........<<<<<<<..<<...<<<<<<<.<<<<.....<<<<<<....>>>>>>......>>>>.....<<<<<<<<<<....>>>>>>>>>>.....<<<<<<<..>>>>>>>.>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<.......<<<....>>>......>>>>...<<<<<<<.........<<<<<<<<<.....>>>>>>>>>..........>>>>>>...>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<.......<<<<<<.....>>>>>>.....>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<......>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<....<<<<<....>>>>>....<<<<..>>>>.>>>>>.>>.<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<......>>>>>...>>>>>>>.....<<<<<.....>>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<..<<<<....<.<<<<..<<<..<<<...>>>.>>>.>>>>.>...>>>>..>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.. ...((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((..(((.(.(((.((..)).))))..)))..)))))......(((.......(((((((..((...(((((((.((((.....(.((((....)))).)......)))).....((((((((((....)))))))))).....((((((....)))))).)))))))..))))))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((........((....)).......))))....((((((...(.....((.((((((.....)))))).)).....)....))))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))...).)))))))..)))))))))..((((.((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))))..)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((......))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((....(((((....)))))....(((....))).))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..((......)))))...)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((..((((....(.((((..(((..(((...))).))).)))).)...))))..))))))..))).))))..).))...)..)..(((((((((....)))))))))}. Bacillus subtilis collided disome (Leading 70S); 16S ribosomal RNA 7qv1 A 26 3.5 35264791 224308 aauaaaugaugcagacaguacuagau .......................... .......................... Bacillus subtilis collided disome (Leading 70S); mRNA 7qv2 A 29 3.5 35264791 224308 aaggaaauaaaaugggacgacguagcauu ............................. ............................. Bacillus subtilis collided disome (Collided 70S); mRNA 7qv2 B 112 3.5 RF00001 URS0000BC467F_224308 35264791 0003735 0005840 224308 ugguggcgauagcgaagaggucacacccguucccauaccgaacacggaaguuaagcucuucagcgccgaugguagucggggguuucccccugugagaguaggacgccgccaa <<<<<<<....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<.......<<.<<<<<...>>>>>.>>.......>>..>>>>>>>. (((((((....((((((((.....((((((...(.....)...))))..))....)))))).)).((.......((.(((((...))))).)).......))..))))))). Bacillus subtilis collided disome (Collided 70S); 5S ribosomal RNA 7qv2 H 77 3.5 RF00005 URS00002C7A07_224308 35264791 0030533 0006412 224308 gguccgguaguucaguugguuagaaugccugccugucacgcaggaggucgcggguucgagucccguccggaccgcca <<<<<<<..<<<<.........>>>>..<<<<.......>>>.>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.........)))).(..(.........)..).....(((((.......)))))))))))).... Bacillus subtilis collided disome (Collided 70S); A/P-site tRNA 7qv2 V 2887 3.5 RF02540,RF02541,RF00002 URS00005906D8_224308 35264791 0003735 0005840 224308 guuaaguuagaaagggcgcacgguggaugccuuggcacuaggagccgaugaaggacgggacgaacaccgauaugcuucggggagcuguaagcaagcuuugauccggagauuuccgaauggggaaacccaccacucguaauggagugguauccauaucugaauucauaggauaugagaaggcagacccggggaacugaaacaucuaaguacccggaggaagagaaagcaaaugcgauucccugaguagcggcgagcgaaacgggaucagcccaaaccaagaggcuugccucuugggguuguaggacacucgaacgagguagaugaagaggucuggaaaggcccgccauaggagguaacagcccuguagucaaaacuucguucgaguggauccugaguacggcggaacacgugaaauuccgucggaauccgggaggaccaucucccaaggcuaaauacucccuagugaccgauagugaaccaguaccgugagggaaaggugaaaagcaccccggaaggggagugaaagagauccugaaaccgugugccuacaaguagucagagcccguuaacgggugauggcgugccuuuuguagaaugaaccggcgaguuacgaucucgugcaagguuaagcagaagaugcggagccgcagcgaaagcgagucugaauagggcgcaugaguacguggucguagacccgaaaccaggugaucuacccauguccagggugaaguucagguaacacugaauggaggcccgaacccacgcacguugaaaagugcggggaugagguguggguaggggugaaaugccaaucgaaccuggagauagcugguucucuccgaaauagcuuuagggcuagccucaagguaagagucuuggagguagagcacugauuggacuaggggccccuaccggguuaccgaauucagucaaacuccgaaugccaaugacuuauccuugggagucagacugcgagugauaagauccguagucgaaagggaaacagcccagaccgccagcuaaggucccaaaguauacguuaaguggaaaaggauguggaguugcuuagacaaccaggauguuggcuuagaagcagccaccauuuaaagagugcguaauagcucacuggucgagugacucugcgccgaaaauguaccggggcuaaacguaucaccgaagcugcggacuguucgaacagugguaggagagcguucuaagggcugugaagccagaccggaaggacugguggagcgcuuagaagugagaaugccgguaugaguagcgaaagaggggugagaauccccuccaccgaaugccuaagguuuccugaggaaggcucguccgcucaggguuagucgggaccuaagccgaggccgaaaggcguaggcgauggacaacagguugauauuccuguaccaccuccucaccauuugagcaauggggggacgcaggaggauaggguaagcgcgguauuggauauccgcguccaagcaguuaggcugggaaauaggcaaauccguuucccaaaggcugagcugugauggcgagcgcgaaguuccugauuccacacugccaagaaaagccucuagcgaggugagaggugcccguaccgcaaaccgacacagguaggcgaggagagaauccuaaggugaucgagagaacucucguuaaggaacucggcaaaaugaccccguaacuucgggagaaggggugcucuguuagggugcaagcccgagagagccgcagugaauaggcccaggcgacuguuuagcaaaaacacaggucucugcgaagccguaaggcgaaguauaggggcugacgccugcccggugcuggaagguuaagaggagcgcuuagcguaagcgaaggugcgaauugaagccccaguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgacccgcacgaaaggcgcaacgaucugggcacugucucaacgagagacucggugaaauuauaguaccugugaagaugcagguuacccgcgacaggacggaaagaccccguggagcuuuacugcagccugauauugaauguugguacagcuuguacaggauagguaggagccuuggaaaccggagcgccagcuucgguggaggcaucggugggauacuacccuggcuguauugaccuucuaacccgccgcccuuaucgggcggggagacagugucaggugggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguucccucagaaugguuggaaaucauucgcagaguguaaaggcacaagggagcuugacugcgagaccuacaagucgagcagggacgaaagucgggcuuagugauccggugguuccgcauggaagggccaucgcucaacggauaaaagcuaccccggggauaacaggcuuaucucccccaagaguccacaucgacggggagguuuggcaccucgaugucggcucaucgcauccuggggcuguagucggucccaaggguugggcuguucgcccauuaaagcgguacgcgagcuggguucagaacgucgugagacaguucggucccuauccgucgcgggcgcaggaaauuugagaggagcuguccuuaguacgagaggaccgggauggacgcaccgcugguguaccaguuguucugccaagggcaucgcuggguagcuaugugcggacgggauaagugcugaaagcaucuaagcaugaagccccccucaagaugagauuucccauuccgcaaggaaguaagaucccugaaagaugaucagguugauaggucugagguggaaguguggcgacacauggagcugacagauacuaaucgaucgaggacuuaacc <<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<..[..((.>>>.....<<<<<<<..<<<))..]..>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<<<<<<<<.........>>>>>>>.>>.>>....<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<......<<.....>>.....>>>>...(((....<<<<<<<<....>>>>>>>>......<<<<<<<<.<<<<<<<<<.<<<.....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>.>>>>..>>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<......>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<.<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>......>>>>>.>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>...>.>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<...<<<<<<<<<.....<<<...<<<<<<<<...<<<<.<<.....>>.>>.>>...>>>>>>>>..>>.>.....>>>>.>>>>>..>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<........>...>>>>>....>>>>>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<..>>>>>>....>>>>>><.<<<<<<<.<.......<<<<<.<<....>>.>>>>>....>.>>>>>>>..>.....>>>>>><......<<....<<<<<<.......>>>>>><<<<....<<<<<.<<<..<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>....<<<<........>>>>.))<<<<<.<<<<<<......<<...<<<<....<<<<..<<<..<<<.<<<<<<<<...(((....>>>>>><<..<<<<<..<<<<<<<<<<<.<<.....>>>>>>>>>...>>>>..>>>>>...>><..<..>...>>>>>>...>>>...>>>>.........>>>>..>>..>>>>>>>>>>>>>>>.>>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<<..............<<<<<....<<..>>.....>>>>><<<<<....<<<<....>>>>...>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>..<<<<.<<<..<<<<<<<..<<<...<<...<<<<<<.<<....>>..>>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>...>>.>>>>>>>....>>>.>>>>>>>>.>>>>>>.....>.(...<<<<<.......)>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<<.<<<.<<<<<<<<<.<............<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>...>.>>>>>>>>>.>>>....<<.<<<<<<.....>>>>>>>>.....>>>>>>>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<.<<<.......>>>.>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<..<<<<<<<...<<.......>>...>>>>>>>...>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.)))>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>>. (((((((......((((((((((.....(((..(((((((((((((......((((((..[..[[.))).....((((((...(((]]..]..)))......))))))...)))....(((....)))(((((((......))))))).(((((((((.........))))))).)).))....((((((.....(...[..)......)))))..)........((....))...((((......((.]...)).....))))...((((...(((((.(((..))).)))))....{.((((((((((((((((((.(((...(.((((......)))))[[(...).(((.....]])))...)))...))))))))))))))..)))))....((((((((..[......))))))))....}.(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((..((((..[...))))..))))...(.(........).).((((((....(((((((.(((((..(((...(((.....)))...)))...((....))..((((.....))))......))))).)))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)<)))...(((.(((((.......A))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((...(((((((((.....(((...((((((((...((..(((.....)))...))...))))))))..)).).....)))).)))))..))))))).)...(((((((.((......)).)))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(.((((((((.....{..((((.((....((.........).)...)).....(...((......).)).))))....)))))))).).))...........]]].)...))))))))))...)))))))((((((()))))))....))))))(.(((((...((......(((((.((....))])))))...))...)))))..).....))))))(......((....((((((.......))))))((((....(((...((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((.((((((......((...((((....((((..(((..(((.((((((((....{{....))))))((..(((((..(((((((((((.((.....)))))))))...))))..)))))...))(..(())...))))))...)))...))))(..).....))))..))..))))))))))))))).))).....((......))..))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.[..).....)))))(((((....((((....))))...)))))(...).......(((((((((.>.((.........))...(((((((.....(((....))).......))))))).]((((.(((..(((((((..(((...((...(((((..((....))...)))))...))...))))))))..)))))(...(.........)...)........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).[..(((((......].)))))..((((((((.(((.((......((((.((((((..(((((.(((((((((.(((....(.(((((.............(((((...((......(((((.((....)).)))))...)).............)))))....))))).)....)))....((.((((((.....)))))))).....)))))))))..)))))..(((......[)))((((((..........]))))))([((...(((((((.....(((.........)).)......((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..a.))..)))))))))))[...(((((((...((((..(.(((((.....(....)....))))).).(((((...((((...(((((((((((.}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..((((....))))....(((.(((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))....)))....))))))). Bacillus subtilis collided disome (Collided 70S); 23S ribosomal RNA 7qv2 a 1545 3.5 RF00177,RF01959,RF01960 URS00023358EF_224308 35264791 0003735 0005840 224308 ggagaguuugauccuggcucaggacgaacgcuggcggcgugccuaauacaugcaagucgagcggacagaugggagcuugcucccugauguuagcggcggacgggugaguaacacguggguaaccugccuguaagacugggauaacuccgggaaaccggggcuaauaccggaugguuguuugaaccgcaugguucaaacauaaaagguggcuucggcuaccacuuacagauggacccgcggcgcauuagcuaguuggugagguaacggcucaccaaggcgacgaugcguagccgaccugagagggugaucggccacacugggacugagacacggcccagacuccuacgggaggcagcaguagggaaucuuccgcaauggacgaaagucugacggagcaacgccgcgugagugaugaagguuuucggaucguaaagcucuguuguuagggaagaacaagugccguucgaauagggcgguaccuugacgguaccuaaccagaaagccacggcuaacuacgugccagcagccgcgguaauacguagguggcaagcguuguccggaauuauugggcguaaagggcucgcaggcgguuucuuaagucugaugugaaagcccccggcucaaccggggagggucauuggaaacuggggaacuugagugcagaagaggagaguggaauuccacguguagcggugaaaugcguagagauguggaggaacaccaguggcgaaggcgacucucuggucuguaacugacgcugaggagcgaaagcguggggagcgaacaggauuagauacccugguaguccacgccguaaacgaugagugcuaaguguuaggggguuuccgccccuuagugcugcagcuaacgcauuaagcacuccgccuggggaguacggucgcaagacugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggucuugacauccucugacaauccuagagauaggacguccccuucgggggcagagugacagguggugcaugguugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuugaucuuaguugccagcauucaguugggcacucuaaggugacugccggugacaaaccggaggaagguggggaugacgucaaaucaucaugccccuuaugaccugggcuacacacgugcuacaauggacagaacaaagggcagcgaaaccgcgagguuaagccaaucccacaaaucuguucucaguucggaucgcagucugcaacucgacugcgugaagcuggaaucgcuaguaaucgcggaucagcaugccgcggugaauacguucccgggccuuguacacaccgcccgucacaccacgagaguuuguaacacccgaagucggugagguaaccuuuuaggagccagccgccgaaggugggacagaugauuggggugaagucguaacaagguagccguaucggaaggugcggcugggaucaccuccuu ...<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<<<...<<<<<<..>>>>>>...>>>>.>>>>>......<<........<<<<<<<..<<...<<<<<<<.<<<<.....<<<<<<....>>>>>>......>>>>.....<<<<<<<<<<....>>>>>>>>>>.....<<<<<<<..>>>>>>>.>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>......<<.<<<....<<<<....>>>>..>>>>>>>.>>>>>>..<<<<.......<<<....>>>......>>>>....<<<<<<.......<.<<<<<<<<<.....>>>>>>>>>..>.......>>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<......<<<<<<<.....>>>>>>.>...>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<......>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<.<......<<........>>..........<<<<<<<......<<<<<<<....<<<<<....>>>>>....<<<<..>>>>.>>>>>.>>.<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<...<<<..<<......>>>>>....>>>>>>.....<<<<<.....>>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>...>..>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<..<<<<....<.<<<<..<<<..<<<...>>>.>>>.>>>>.>...>>>>..>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.............. ...((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((.(.(((.((..)).))))..)))).)))))......(((.......(((((((..((...(((((((.((((.....(.((((....)))).)......)))).....((((((((((....)))))))))).....((((((....)))))).)))))))..))))))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....((((((...(.....(((((((((.....))))))))).....)....))))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((.(((((((......((((((.....))))))...).))))))...)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((......))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((....(((((....)))))....(((....))).))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..((......)))))...)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((...(((((..((((....(.((((..(((..(((...))).))).)))).)...))))..)))))...))).))))..).))...)..)..(((((((((....)))))))))}............. Bacillus subtilis collided disome (Collided 70S); 16S ribosomal RNA 7qv2 x 76 3.5 RF00005 URS00005477C0_224308 35264791 0030533 0006412 224308 gguccgguaguucaguugguuagaaugccugccugucacgcaggaggucgcggguucgagucccguccggaccgcc ..<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>..... ..((((...((((.........)))).(((...........))).....(((((.......))))).))))..... Bacillus subtilis collided disome (Collided 70S); P/E-site tRNA 7qv3 A 26 5.14 35264791 224308 aauaaaugaugcagacaguacuagau .......................... .......................... Bacillus subtilis MutS2-collided disome complex (MutS2 conf.2; Leading 70S); mRNA 7qv3 B 112 5.14 RF00001 URS0000BC467F_224308 35264791 0003735 0005840 224308 ugguggcgauagcgaagaggucacacccguucccauaccgaacacggaaguuaagcucuucagcgccgaugguagucggggguuucccccugugagaguaggacgccgccaa <<<<<<<....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<.......<<.<<<<<...>>>>>.>>.......>>..>>>>>>>. (((((((....((((((((.....((((((...(.....)...))))..))....)))))).)).((.......((.(((((...))))).)).......))..))))))). Bacillus subtilis MutS2-collided disome complex (MutS2 conf.2; Leading 70S); 5S ribosomal RNA 7qv3 H 77 5.14 RF00005 URS00002C7A07_224308 35264791 0030533 0006412 224308 gguccgguaguucaguugguuagaaugccugccugucacgcaggaggucgcggguucgagucccguccggaccgcca <<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.........)))).(((((.......))))).....(((((.......)))))))))))).... Bacillus subtilis MutS2-collided disome complex (MutS2 conf.2; Leading 70S); P-site tRNA 7qv3 V 2887 5.14 RF02540,RF02541,RF00002 URS0002335902_224308 35264791 0003735 0005840 224308 guuaaguuagaaagggcgcacgguggaugccuuggcacuaggagccgaugaaggacgggacgaacaccgauaugcuucggggagcuguaagcaagcuuugauccggagauuuccgaauggggaaacccaccacucguaauggagugguauccauaucugaauucauaggauaugagaaggcagacccggggaacugaaacaucuaaguacccggaggaagagaaagcaaaugcgauucccugaguagcggcgagcgaaacgggaucagcccaaaccaagaggcuugccucuugggguuguaggacacucgaacgagguagaugaagaggucuggaaaggcccgccauaggagguaacagcccuguagucaaaacuucguucgaguggauccugaguacggcggaacacgugaaauuccgucggaauccgggaggaccaucucccaaggcuaaauacucccuagugaccgauagugaaccaguaccgugagggaaaggugaaaagcaccccggaaggggagugaaagagauccugaaaccgugugccuacaaguagucagagcccguuaacgggugauggcgugccuuuuguagaaugaaccggcgaguuacgaucucgugcaagguuaagcagaagaugcggagccgcagcgaaagcgagucugaauagggcgcaugaguacguggucguagacccgaaaccaggugaucuacccauguccagggugaaguucagguaacacugaauggaggcccgaacccacgcacguugaaaagugcggggaugagguguggguaggggugaaaugccaaucgaaccuggagauagcugguucucuccgaaauagcuuuagggcuagccucaagguaagagucuuggagguagagcacugauuggacuaggggccccuaccggguuaccgaauucagucaaacuccgaaugccaaugacuuauccuugggagucagacugcgagugauaagauccguagucgaaagggaaacagcccagaccgccagcuaaggucccaaaguauacguuaaguggaaaaggauguggaguugcuuagacaaccaggauguuggcuuagaagcagccaccauuuaaagagugcguaauagcucacuggucgagugacucugcgccgaaaauguaccggggcuaaacguaucaccgaagcugcggacuguucgaacagugguaggagagcguucuaagggcugugaagccagaccggaaggacugguggagcgcuuagaagugagaaugccgguaugaguagcgaaagaggggugagaauccccuccaccgaaugccuaagguuuccugaggaaggcucguccgcucaggguuagucgggaccuaagccgaggccgaaaggcguaggcgauggacaacagguugauauuccuguaccaccuccucaccauuugagcaauggggggacgcaggaggauaggguaagcgcgguauuggauauccgcguccaagcaguuaggcugggaaauaggcaaauccguuucccaaaggcugagcugugauggcgagcgcgaaguuccugauuccacacugccaagaaaagccucuagcgaggugagaggugcccguaccgcaaaccgacacagguaggcgaggagagaauccuaaggugaucgagagaacucucguuaaggaacucggcaaaaugaccccguaacuucgggagaaggggugcucuguuagggugcaagcccgagagagccgcagugaauaggcccaggcgacuguuuagcaaaaacacaggucucugcgaagccguaaggcgaaguauaggggcugacgccugcccggugcuggaagguuaagaggagcgcuuagcguaagcgaaggugcgaauugaagccccaguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgacccgcacgaaaggcgcaacgaucugggcacugucucaacgagagacucggugaaauuauaguaccugugaagaugcagguuacccgcgacaggacggaaagaccccguggagcuuuacugcagccugauauugaauguugguacagcuuguacaggauagguaggagccuuggaaaccggagcgccagcuucgguggaggcaucggugggauacuacccuggcuguauugaccuucuaacccaccgcccuuaucgggcggggagacagugucaggugggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguucccucagaaugguuggaaaucauucgcagaguguaaaggcacaagggagcuugacugcgagaccuacaagucgagcagggacgaaagucgggcuuagugauccggugguuccgcauggaagggccaucgcucaacggauaaaagcuaccccggggauaacaggcuuaucucccccaagaguccacaucgacggggagguuuggcaccucgaugucggcucaucgcauccuggggcuguagucggucccaaggguugggcuguucgcccauuaaagcgguacgcgagcuggguucagaacgucgugagacaguucggucccuauccgucgcgggcgcaggaaauuugagaggagcuguccuuaguacgagaggaccgggauggacgcaccgcugguguaccaguuguucugccaagggcaucgcuggguagcuaugugcggacgggauaagugcugaaagcaucuaagcaugaagccccccucaagaugagauuucccauuccgcaaggaaguaagaucccugaaagaugaucagguugauaggucugagguggaaguguggcgacacauggagcugacagauacuaaucgaucgaggacuuaacc .<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<..[..((.>>>.....<<<<<<<..<<<))..]..>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<<<<<<<<.........>>>>>>>.>>.>>....<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<......<<.....>>.....>>>>...(((....<<<<<<<<....>>>>>>>>......<<<<<<<<..<<<<<<<<.<<<.....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>..>>>>..>>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<......>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<.<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>......>>>>>.>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>...>.>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<...<<<<<<<<<.....<<<...<<<<<<<<...<<<<.<<.....>>.>>.>>...>>>>>>>>..>>.>.....>>>>.>>>>>..>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>...>>>>>>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<..>>>>>>....>>>>>><.<<<<<<<.<.......<<<<<.<<....>>.>>>>>....>.>>>>>>>..>.....>>>>>><......<<....<<<<<<.......>>>>>><<<<....<<<<<.<<<..<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<.<<<<<<......<<...<<<<....<<<<..<<<..<<<.<<<<<<<<...(((....>>>>>><<..<<<<<..<<<<<<<<<<<.<<.....>>>>>>>>>...>>>>..>>>>>...>><..<..>...>>>>>>...>>>...>>>>.........>>>>..>>..>>>>>>>>>>>>>>>.>>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<.....<<<<....>>>>....>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>..<<<<.<<<..<<<<<<<..<<<...<....<<<<<..<<....>>...>>>>>....>...>>>>>>>>..>>>>><<<<<.........>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>...>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<<.<<<.<<<<<<<<<.<.............<.<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>.>...>..>>>>>>>>>.>>>....<<.<<<<<<.....>>>>>>>>.....>>>>>>>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.)))>>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>.. .((((((......((((((((((.....(((..(((((((((((((......((((((..[..[[[)))...].((((((...(((]]..]..)))......))))))...)))....(((....)))(((((((......))))))).(((((((((.........))))))).)).))....((((((.....(...[..)......))))).).........((....))...((((......((.]...)).....))))...((((...(((((((((..)))))))))....{.(((((((((.((((((((.(((...(.((((......)))))[[(...).(((.....]])))...)))...)))))))).)))))..)))))....((((((((..[......))))))))....}.(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((..((((..[...))))..))))...(.(........).).((((((....(((((((.(((((..((....(((.....)))....))...((....))..((((.....))))......))))).)))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)<)))...(((.(((((.......A))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((...((((((.((.....(((...((((((((...((..(((.....)))...))...))))))))..)).).....)).).)))))..))))))).))..(((((((.((......)).)))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((((.((.....{.(((((.(((...((.........).)..)))..........(......)....)))))...)).))))))).))...........]]].)...))))))))))...)))))))((((((()))))))....))))))(((((((...((......(((((.((....))])))))...))...))))).)).....))))))(......((....((((((.......))))))((((....(((...((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((.((((((......((...((((....((((..(((..(((.((((((((....{{....))))))((..(((((..(((((((((((.((.....)))))))))...))))..)))))...))(..(())...))))))...)))...))))(..).....))))..))..))))))))))))))).))).....((......))..))).((((.....))))..))))...(((....((((((((.((..(....(.......(((((....(.[..).....)))))((((.....((((....))))....))))(...).......(((((((((.>.((.........))...(((((((.....(((....))).......))))))).](((..(((..(((((((..(((...(....(((((..((....))...)))))....)...))))))))..)))))((((...........))))........((..........(((((.......)))))..)..).....)))...)).))))))).)..))).)))))))).))).)).....)).[..(((((......].)))))..((((((((.(((.((......((((.((((((..(((((.(((((((((.((..(..(.((((..............((.((..(((......(((.((((....)))).)))...)))............)).)).....)))).)...).))....(..((((((.....)))))).).....)))))))))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..a.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..((((....))))....(((.(((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))....)))....)))))).. Bacillus subtilis MutS2-collided disome complex (MutS2 conf.2; Leading 70S); 23S ribosomal RNA 7qv3 a 1533 5.14 RF00177,RF01959,RF01960 URS000197CF6E_224308 35264791 0003735 0005840 224308 ggagaguuugauccuggcucaggacgaacgcuggcggcgugccuaauacaugcaagucgagcggacagaugggagcuugcucccugauguuagcggcggacgggugaguaacacguggguaaccugccuguaagacugggauaacuccgggaaaccggggcuaauaccggaugguuguuugaaccgcaugguucaaacauaaaagguggcuucggcuaccacuuacagauggacccgcggcgcauuagcuaguuggugagguaacggcucaccaaggcgacgaugcguagccgaccugagagggugaucggccacacugggacugagacacggcccagacuccuacgggaggcagcaguagggaaucuuccgcaauggacgaaagucugacggagcaacgccgcgugagugaugaagguuuucggaucguaaagcucuguuguuagggaagaacaagugccguucgaauagggcgguaccuugacgguaccuaaccagaaagccacggcuaacuacgugccagcagccgcgguaauacguagguggcaagcguuguccggaauuauugggcguaaagggcucgcaggcgguuucuuaagucugaugugaaagcccccggcucaaccggggagggucauuggaaacuggggaacuugagugcagaagaggagaguggaauuccacguguagcggugaaaugcguagagauguggaggaacaccaguggcgaaggcgacucucuggucuguaacugacgcugaggagcgaaagcguggggagcgaacaggauuagauacccugguaguccacgccguaaacgaugagugcuaaguguuaggggguuuccgccccuuagugcugcagcuaacgcauuaagcacuccgccuggggaguacggucgcaagacugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggucuugacauccucugacaauccuagagauaggacguccccuucgggggcagagugacagguggugcaugguugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuugaucuuaguugccagcauucaguugggcacucuaaggugacugccggugacaaaccggaggaagguggggaugacgucaaaucaucaugccccuuaugaccugggcuacacacgugcuacaauggacagaacaaagggcagcgaaaccgcgagguuaagccaaucccacaaaucuguucucaguucggaucgcagucugcaacucgacugcgugaagcuggaaucgcuaguaaucgcggaucagcaugccgcggugaauacguucccgggccuuguacacaccgcccgucacaccacgagaguuuguaacacccgaagucggugagguaaccuuuuaggagccagccgccgaaggugggacagaugauuggggugaagucguaacaagguagccguaucggaaggugcggcugg ...<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<<<...<<<<<<..>>>>>>...>>>>.>>>>>......<<........<<<<<<<..<<...<<<<<<<.<<<<.....<<<<<<....>>>>>>......>>>>.....<<<<<<<<<<....>>>>>>>>>>.....<<<<<<<..>>>>>>>.>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<.......<<<....>>>......>>>>...<<<<<<<.........<<<<<<<<<.....>>>>>>>>>..........>>>>>>...>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<.......<<<<<<.....>>>>>>.....>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<......>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<....<<<<<....>>>>>....<<<<..>>>>.>>>>>.>>.<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<......>>>>>...>>>>>>>.....<<<<<.....>>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<..<<<<....<.<<<<..<<<..<<<...>>>.>>>.>>>>.>...>>>>..>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.. ...((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((..(((.(.(((.((..)).))))..)))..)))))......(((.......(((((((..((...(((((((.((((.....(.((((....)))).)......)))).....((((((((((....)))))))))).....((((((....)))))).)))))))..))))))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((........((....)).......))))....((((((...(.....((.((((((.....)))))).)).....)....))))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))...).)))))))..)))))))))..((((.((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))))..)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((......))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((....(((((....)))))....(((....))).))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..((......)))))...)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((..((((....(.((((..(((..(((...))).))).)))).)...))))..))))))..))).))))..).))...)..)..(((((((((....)))))))))}. Bacillus subtilis MutS2-collided disome complex (MutS2 conf.2; Leading 70S); 16S ribosomal RNA 7qvp A4 14 3.0 36302773 9606 uuuuuuuuuuuuuu .............. .............. Human collided disome (di-ribosome) stalled on XBP1 mRNA; mRNA 7qvp A5 11 3.0 36302773 9606 uuuuuuuuuuu ........... ........... Human collided disome (di-ribosome) stalled on XBP1 mRNA; mRNA 7qvp B4 76 3.0 RF00005 URS00005AA258_9606 36302773 0030533 0006412 9606 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>><<<<<<<.....>>>>>>.>...<<<<<.......>>>>>>>>>>>>.... .((((((..((((.....[..)))).(((((.......))))).....((.((..]....)).))))))))..... Human collided disome (di-ribosome) stalled on XBP1 mRNA; tRNA P/P 7qvp B5 75 3.0 RF00005 URS0000326EAC_9606 36302773 0030533 0006412 9606 agcagaguggcgcagcggaagcgugcugggcccauaacccagaggucgauggaucgaaaccauccucugcuacca <<<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... ((((.((..((((.......)))).(((((.......))))).....(((((.......))))))).)))).... Human collided disome (di-ribosome) stalled on XBP1 mRNA; tRNA P/E 7qvp CC 75 3.0 RF00005 URS0000E60BA3_9606 36302773 0030533 0006412 9606 uccgauauagcguaacggcuaucacaucacgcuuucaccguggagaccgggguucgacuccccguaucggagcca <<<<<<<....<..........>...<<<<<.......>>>>>....<<<<<.......>>>>>>>>>>>>.... (((((((..(.(.....[....).).(((((.......)))).)...(((((..]....)))))))))))).... Human collided disome (di-ribosome) stalled on XBP1 mRNA; tNRA E/E 7qvp D5 73 3.0 RF00005 URS00005AA258_9606 36302773 0030533 0006412 9606 gcccggauagcucagggagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca .<<<<....<<<.......>>>.<<<<.<....>..>>>>.....<<<...........>>>.>.>>>..... .(.(.(...((.....[...))..(((.........)).).....((.....].......))..)))...... Human collided disome (di-ribosome) stalled on XBP1 mRNA; tRNA P/P 7qvp L1 156 3.0 RF00002,RF02540 URS0000005270_9606 36302773 0003735 0005840 9606 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<.<<.....>>>.....(.<<<......>>.............>>>..)...>>>....<<....>><<<<<<<<<.....>>>>>>>>>.................... .........................................((((((.[[....[)))...].(.(((......]].............)))..)...)))....((....))(((((((((.....))))))))).................... Human collided disome (di-ribosome) stalled on XBP1 mRNA; 5.8S ribosomal RNA 7qvp L5 3611 3.0 RF02543 URS0002617717_9606 36302773 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcgguccggccgugucggcggcccggcggaucuuucccgcgcgggggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucgggggcccccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcgcucuccccccucccggggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccgggggggccacgcgcgcgucccccgagggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcagacccgaccgccacgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaagaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggcgcuaaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagcggcggcgcgcccggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcugggucggucgcggccggcgccuagcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacacguuuuuucacugacccggugaggcgggggggcgagccccgaggggcucucgcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccggucccccgccgggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..[[[...<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>...<<<<<<<<<<...<<<<<<<<........<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>...>>>>>>>>..>>>>>>>>>>.......<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<<<.<<<<<<<..<.........<<<<<.<<<..<<......>>>>>>>>>>....>..>>>>...>>>>>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<.<<<<<<<<<<<<<<<...<<..<<<.<<.<<<<......<<<<<<<<..>>>>>>>>.......>>>>.>>>>>........>>>>>>..>>>>>>>>>>>....................<<<<<<.<<<<<<<....>>>>>>>.<<<<<<.<<<<.<<<<<<<<<<<.<<<<..<<<<..<...........>...>>>>..>>>>.>.>>>>>>>.>>>...>>>>.>>>>.>>..<<<<<<<<<<..>>>>>>>>.>>....>>>>>>......>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<......>>>>>>>..<<<<<...<<<..<<<....[[.((((>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<...................<<<.<<<<<<<<<...<<<....<<<..<.<<<.....<<<........>>>...>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.........>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<..<<....>>.....>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<..........)))).]]..................................>>>>>>>>>....>>>>>>.<<<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>.>>.....>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<...........>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<..<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..{{{..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<.......................>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<...<.<<<<....>>>>.>...>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<<.<<<<<<<<......>>>>>>>>...<<<<<.....<<<<........<........>...................<<<<<<<<<<.......>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>><<<<....>>>>>>)))]......((((((..(((..>>>>>>.)))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]].....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<}}}.>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.....<<<<<<..<<..<<<<....<<<........<<<<<.<<<<....>>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>..............>>>>..>>.>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<....<<<<<......>>>>>...>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((...((((((((((.....)))))).)))).....)))....((((((((((...(((.((((...(....((((((((..({((((......)))))....[[(...).(((....}]])))...).))))))))..))).))))..))))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....(((((((((((.(((.(((....(...(....((((.((....(......)..)))))).)..)...)))....))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((.(..((((......((((((((..)))))))).......))))..))))........))))))..)))))))))))......{.............((((((.(((((((....))))))).((((((.((((.((((((((((..((((..((((..................))))..))))...))))))).)))...)))).)))).))..((((((((((..)))))))).))....)))))).....))).)))))...)))))...)))))))).<((((........))))((((((....(((((((((((((..(((..(((((........))))..)..)))...((....))...(((((((......)))))))..(((((...(((..(((...[....[[[)))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......B)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((...................(((.((((((((....(((....(((..(.(((..(...((........))..).))).)..)))..)).)....))))))...(((((((((.(......))))))))))....))))))))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.....A.(.((...............))..)..)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((........}.]]]....]....................(...)........)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((..(((((((...((.....)).))))))....[[(((.((...((....(((....)))..........((.(((((...(....)..)))))))......))....))...(((((........)))))]]((((....(((((...((.((((....)))).))..((((....)))...(...((((((...(((((((((((((((((((((((..{{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....(((((((.......))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).))).))).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((.(((((((.......................)))))..)).))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(..(((.....((((....)))).....))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.(((((((((.(((((((........)))))))...(((((.....((((.....((............))................(.((((((((.......)))))))).)..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..b.))..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((.....(((....((.((((((.}}}..))))..)).))...)))....)))).((((...((((.....a.......))))...))))..)))...).)))))).....((((((..((..((((.(..(((........(((((.((((....)))).))))).......)))...(((..((((....((((.(((((((......)))))))))))...))))..)))...........)..))))..)).))))))(((((.(..(.......)..)....((.(((((((.((.....((.(.(..(((((......)))))..)).))....))....)))).))).))..))))).. Human collided disome (di-ribosome) stalled on XBP1 mRNA; 28S ribosomal RNA 7qvp L6 3572 3.0 RF02543 URS0002617717_9606 36302773 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcggcccggcggaucuuucccgcgcgggggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucgggggcccccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcgcucuccccccucccgggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccgggggaggccacgcgcgcgucccccgagggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcagacccgaccgccacgcaguuuuauccgguaaagcgaaugauuagaggucuuggggcucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacccgcuaagcaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagcgcggcgcgcgccccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgaccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcuggguccggccggcgccuagcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagaguuuucacugacccggugaggcgggggggcgagccgggcucucgcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccggucccccgccgggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcuucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..[[[...<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>...<<<<<<<<<<...<<<<<<<<........<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>...>>>>>>>>..>>>>>>>>>>.......<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<<<..<<<<<<<.......<.....<<<<.<<<..<<......>>>>>>>>>.>......>>>>...>>>>>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<.<<<<<<<<<<.<<<<...<<..<<<....<<<<......<<<<<<<....>>>>>>>.......>>>>...>>>........>>>>>>...>>>>>>>>>>....................<<<<<..<<<<<<<...>>>>>>>.<<<<<<.<<<<.<<<<<<<<<<..<<<<<.<<<<..<...........>...>>>>.>>>>>...>>>>>>>.>>>...>>>.>.>>>>.>>..<<<<<<<<<<..>>>>>>>>.>>.....>>>>>......>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<......>>>>>>>..<<<<<...<<<..<<<..[[[..((((>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<...................<<<.<<<<<<<<<...<<<....<<<..<.<<<<....<.....>..>>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.........>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<..............>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<..........))))..]]]..........................>>>>>>>>>....>>>>>>.<<<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>.>>.....>>>>>><<<....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<.......>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<..<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..{{{..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<..................>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>...>>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<<.<<<..<...>..>>>...<<<<<.....<<<<..<.............>...............<<<<<<<<<<.......>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>><<<<....>>>>>>)))]......((((((..(((..>>>>>>.)))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]].....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<}}}.>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>......<<<<<<.<<..<<<<....<<<........<<<<<.<<<<....>>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>..............>>>>..>>>>>>>>.<<<<<....................<<.<<<<<<<.<<.....<<<<....<<<<<...>>>>>...>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((...((((((((((.....)))))).)))).....)))....((((((((((...(((.((((...(....((((((((..({((((......)))))....[[(...).(((....}]])))...).))))))))..))).))))..))))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....(((((((((((..(((((((....(..((.....(((.((....(......)..))))).)).)....))))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((..(.((((......(((((((....))))))).......))))..))))........))))))..)))))))))))....................((((((.((((((.....)))))).((((((.((((.(((((((((((.(((((.((((..................)))).))))).).))))))).)))...))).).)))).))..((((((((((..)))))))).))....)))))).....))).)))))...)))))...)))))))).[((((........))))((((((....(((((((((((((..(((..((((..........)))..)..)))...((....))...(((((((......)))))))..(((((...(((..(((..[[....[[[)))..)))....))))).(((((((((..((((...).)).)))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((...................(((.((((((((....(((....(((..(.((((.............)))).)..)))..)).)....))))))...(((((((((.(......))))))))))....))))))))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.....{.((..(.............).))...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((..........]]]....]].............(...)........)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((..(((((((...((.....)).))))))....[[(((.((...((....(((....)))..........((.((((.......))))))......))....))...(((((........)))))]]((((....(((((...((.((((....)))).))..((((....)))...(...((((((...(((((((((((((((((((((((..{{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....(((((((.......))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).))).))).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((...(.....)........)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.....((.....((((....)))).....))..))))..)))))(((((.........)))))........((..........((((.(......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.(((((((((.((...........))...(((((.....((((.....(.........)................((((((((((.......))))))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(.(((.(((((....{..)))).)))))(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a.))..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}}.)))))..)).))...))))...)))).((((...((((.....}.......))))...))))..)))...).)))))).....(((((((.((..((((.(..(((........(((((.(((.(...)))).))))).......)))...(((..((((....((((.(((((((......)))))))))))...))))..)))...........)..))))..)))))))))(((((.(..(.......)..)....((.(((((((.((.....((((.(..(((((...)))))..)))))....))....)))).))).))..))))).. Human collided disome (di-ribosome) stalled on XBP1 mRNA; 28S ribosomal RNA 7qvp L7 120 3.0 RF00001 URS00000F9D45_9606 36302773 0003735 0005840 9606 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....(((.((...(....)...)).)..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. Human collided disome (di-ribosome) stalled on XBP1 mRNA; 5S ribosomal RNA 7qvp L8 156 3.0 RF00002,RF02540 URS0000005270_9606 36302773 0003735 0005840 9606 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<.<<.....>>>.....(.<<<......>>.............>>>..)...>>>....<<....>><<<<<<<<<.....>>>>>>>>>.................... .........................................((((((.[[....[)))...].(.(((......]].............)))..)...)))....((....))(((((((((.....))))))))).................... Human collided disome (di-ribosome) stalled on XBP1 mRNA; 5.8S ribosomal RNA 7qvp L9 120 3.0 RF00001 URS00000F9D45_9606 36302773 0003735 0005840 9606 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (.(((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))).).. Human collided disome (di-ribosome) stalled on XBP1 mRNA; 5S ribosomal RNA 7qvp S2 1714 3.0 RF01960,RF02542,RF01959,RF00177 URS00005A14E2_9606 36302773 0003735 0005840 9606 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucgcacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgccccccguggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcgggcguccccgccccucucggcgcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgacccccgagcggucggcguccaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<....<<....<<<<<.........<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<<......>>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<<......>>>>>>>>.>>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....<<.<<<<<<............>>.>>>>..>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<...........................................<<<<<<.<.......<<...<.......>.<<<<.......>>>>...>>......>.>>>..>>>........<.<<.<<<<<<<...............>>>>>>>.>>.>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<......<<<<<<.......<<.<<<........>>>.>>.....>>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<.......>>>>.>>>>..>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>>......>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<.<....<.....>.....>...>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))(((.((.(((...(.((..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..((....((((....((......(....((.(((.....))).))......).......)).((((....(((........)))....))))((...((((...(......)..)))).......)).(.((((.((((......))))))))).).)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).).....((.(((((..............).))))..))......((..(...........)..)).........((((([[......((((.....((..]])).......)))).)))))..))).)).)))..[......(.(.[...(.(.((...(((..(...........................................(((..(.(.......((..((.......)).((.(......)))....))......).)....)))........(.((.(.(..((...............))..).).)).)....)....(.(.((...(...((((..((..((((((((...((........))......))))))))..)).......((....))...))))..)...))..)...))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.((...(.(.((.(.(((........)))).)).).)...))....(..].)....))...].))))).).(((......((((....))))....)))...]]].]((.((.(((((((..((..(((((..(((.((((((......((........))........(.(((((.(....((((((....(..((.(((........))).))....)))))))...((.(((...(.((((((.(..(((.(((((....)))..(.((......)))...)).)))....(((...(...((((..((((((((((((.......)))).))))..))))..))))..).....(((((.....)))))........))).)..))).))).....).))))).....).))))))..)).)))).))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....((((((((.......))))))))......))...)))))))))..))..(.(..((.(..((((.((..(.((((((((.(((..((((.((...((.((((................).).)).))...)).))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}........ Human collided disome (di-ribosome) stalled on XBP1 mRNA; 18S ribosomal RNA 7qvp S3 1705 3.0 RF01960,RF02542,RF01959,RF00177 URS00005A14E2_9606 36302773 0003735 0005840 9606 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucgacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuugggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgcccguggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcgggcgggcgguccgccgcgaggcgagccaccgcccguccccgccgcguuuacuuugaaaaaauuagaguguucaaagcaggcccccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuuuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgaccccgcggucggcgucaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggugcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<....<<....<<<<.........<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<.....>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<<...>>>>>>>>..>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>....<<.<<<<<<............>>.>>>>..>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<..........<<<<<<<<<<<.<<<<....>>>>>....>>>>>>>>>>.........<<<<<<.<.......<<...<.......>.<<<<....>>>>...>>......>.>>>..>>>........<.<<.<<.<<<<..........>>>>.>>.>>.>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<<....>>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<......>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<......<<<<<<.......<<.<<<........>>>.>>.....>>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<....>>>>.>>>>.>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>>......>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>............<<<<<..........>>>>>...........>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<...<<......>>.....>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))(((.((.(((...(.((..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..(.....(((.....((...((.....((.(((.....))).))......))......))..(((...((((.....))))...))).....(((((...(......)..))))).........(.((((.((((...)))))))))...)))....)).).))).(((....(((....(((((((.........))))))))))......)))...(((.(((......)))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).)....((.(.((((............)).))..).).)...(.....(...........)..........)..((((([[......((((.....((..]])).......)))).)))))..))).)).)))..[......(.([[...(.(.((...(((..(........(.((.((((((...((((....))))......)))))).)).).......((((((.(.......((..((.......)).((.(...)))....))......).)))..)))........(.((.(....(............)....).)).)....)....(((.(((..(...((((..((..((((((((...((........))......))))))))..)).......((....))...))))..)..)))..))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.((((......)))))))))).)..)))...((..]]))...))...].))))).).(((......((((....))))....)))...]]].]((.((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....((((((....(..((.(((........))).))....)))))))....(.(((...(.((((((.(..(((.(((((....)))..(.((......)))...)).)))....(((...(...((((..((((((((((((....)))).)))).))))..))))..).....(((((.....)))))........))).)..))).))).....).))))......).)))))...)).)))).))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....((((((((.......))))))))......))...)))))))))..))..(.(..((.(..((((.((..(.(((((((..(((..((((.((...((.((((..(......)..).).)).))...)).))))..)))..))))))))..)).))))...).))...)..)..(((((((((....)))))))))}........ Human collided disome (di-ribosome) stalled on XBP1 mRNA; 18S ribosomal RNA 7qwq 5 3493 2.83 RF02543,RF02540 URS00023358FA_9986 35201867 0003735 0005840 9986 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccgguucaacccggcggcggguccggccgugucggcgggucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucggccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcgcucuccccccucgggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccgggggaggggccacgcggcgagcgcacggggucggcggcgacgucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcacacgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcgugagccgggcguggaauggagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagagccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagcccgcccccggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcugggucggucgucggccggcgccuagcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacauguuuuuucacugacccggugaggcgggggggcgcucgcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccggucccccgcgggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcacgccguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..[[[....<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>....<<<<<<<<<....<<<<<<<<.<......<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>..>>>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<......>>>..................................<<<<<<<<..<<<......<<<<<<<<.....<<<<<<<<<<<...<<<....<<<<<.<....>>>.>>>......>>>.>>>>>>>>>>>..........>>>.>>>>>..<<<<<<<..<<<<<<<<<<.<<<..........<<<<.<<<<......<<<<<..>>>>>.......>>>>.>>>>............>>>...>>>>>>>>>>....................<<<<<..<<<<<<<.>>>>>>>.<<.<<<.<<<<..<<<<<<<<<<<<<<<<<<<<<<<.<<<<....>>>>.>>>>>>>>>>.>>>>>>>>>>>.>>....>.>>>...>>>..>>.....>>>>>.......>>.>>>>>....>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<<....>>>>>>>>..<<<<<...<<<..<<<...(((..[[.>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<<...<<<<<<<....>>>>>>>...>.>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<............<<<<<<<<<...<<<....<<<..<.<<<..<<<<.<.<.....>.>.>>>>>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<..<...>.>>>>>>>>>...>>...>>>>>>>.>>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<............>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<...........]].)))..............................>>>>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<<<<<...>>>>>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<....<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<<<<<<<<<<<<..{{{..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<<....>.>>>>>>>>>>>.>.>>>>>>>>>>>>.........>>>>>>>..>.............>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<.<<<<<<<<<<<...<<<<<<.>>>>>>........>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>>.<<<<<.......>>>>>.........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<<.<<<<<<<<<<..>>>>>>>>>>...<<<<<.....<<<<..<<...>>..............<<<<<<<<<<<.....>>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>>.<<<....>>>.>>))).......((((((..(((..>>>>>>.)))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]].....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<}}}.>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>......<<<<<<.<<..<<<.....<<.........<<<<<..<<<<..>>>>.>>>>>........>>....<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>..............>>>..>>>>>>>>.<<<<<.<.............>....<<.<<<<<<<.<<.....<<<<....<<<<<......>>>>>...>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..(((((((((((.....)))))).))))....))))....((((((.((....((((((((.(......((((((((..({((((......)))))....[[(...).(((....}]])))...).)))))))..)))))))))...)).))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((......((((((((.....(((((((((((...(((.(..(((((.((..)))).)))..)...))).)))))))))))..........))).)))))..((((((((.((((.(((((.(((....(...(.((((.((((.......((((()))))........)))).))))).........).)))...))))).))))....................(((((..((((((...))))))..((..(.((((..(((((((((((((((((((((((.((((....)))).)))))))))).))))))))))).))....).)))...).)..)......)))))......))).)))))....)))...)))))))).[((((........))))((((((....(((((((((((((..(((..(((((........)))).)...)))...((....))...((((((((....))))))))..(((((...(((..(((...[[[...[[)))..)))....))))).(((((((((.((((......))))))))))).))....)))))))))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((..........(.(.((((((....(((....(((..(.(((..((((.(.(.....)..)))))))).)..)))..)).)....))))))...(((((((((........)))))))))....).).)))))))..))..((((.((.((.....)).)).))))....(((......)))...(((((((...((([[[.....(.(((((......(..........(((.((((((((..............)))))))))))..........]]].)....)))))).)))...)))))))((((((.(((..........]]..]]]..............................)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...((..(.(((....))).....)....((.((((.(.((...)).).))))))......))....))...(((((........)))))]]((((....(((.....((.((((....)))).))...(((....)))...(...((((((...((((((((((((((((((((((....{{..).))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...).............))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((...((((((.))))).).......)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(..(((.....((((....)))).....))))))))..)))))..(((.........)))..........((.(......).(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.(((((((((.((((((((((..))))))))))...(((((.....((((..(..().)..............(((((((((((.....)))))))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a.))..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}..)))))..)).))...))))...)))).((((...((((.............))))...))))..)))...).))))))......(((((..(...((......((..........(((...((((()))))..))).........))....((...(((....((((.(((((((......)))))))))))...)))...))...............))...).))))).(((((.(..(.......)..)....(..(((((((.((.....((((.(..(((((......)))))..)))))....))....)))).)))..)..))))).. Ternary complex of ribosome nascent chain with SRP and NAC; 28S rRNA 7qwq 7 120 2.83 RF00001 URS000002B0D5_9986 35201867 0003735 0005840 9986 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (.(((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))).).. Ternary complex of ribosome nascent chain with SRP and NAC; 5S ribosomal RNA 7qwq 8 156 2.83 RF00002 URS00004B2C76_9986 35201867 0003735 0005840 9986 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<.<<.....>>>.....(.<<<......>>.............>>>..)...>>>....<<<..>>><<<<<<<<.......>>>>>>>>.................... .........................................((((((.[[....[)))...].(.(((......]].............)))..)...)))....((....))((((((((.......)))))))).................... Ternary complex of ribosome nascent chain with SRP and NAC; 5.8S ribosomal RNA 7qwr 5 3493 2.9 RF02543,RF02540 URS00023358FA_9986 35201867 0003735 0005840 9986 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccgguucaacccggcggcggguccggccgugucggcgggucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucggccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcgcucuccccccucgggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccgggggaggggccacgcggcgagcgcacggggucggcggcgacgucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcacacgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcgugagccgggcguggaauggagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagagccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagcccgcccccggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcugggucggucgucggccggcgccuagcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacauguuuuuucacugacccggugaggcgggggggcgcucgcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccggucccccgcgggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcacgccguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>>..<<<<<<<<<....<<<<<<<<.<......<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>..>>>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<......>>>..................................<<<<<<<<..<<<......<<<<<<<<.....<<<<<<<<<<<...<<<....<<<<<.<....>>>.>>>......>>>.>>>>>>>>>>>..........>>>.>>>>>..<<<<<<<..<<<<<<<<<<.<<<..........<<<<.<<<<......<<<<<..>>>>>.......>>>>.>>>>............>>>...>>>>>>>>>>....................<<<<<..<<<<<<<.>>>>>>>.<<.<<<.<<<<..<<<<<<<<<<<<<<<<<<<<<<<.<<<<....>>>>.>>>>>>>>>>.>>>>>>>>>>>.>>....>.>>>...>>>..>>.....>>>>>.......>>.>>>>>....>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<<....>>>>>>>>..<<<<<...<<<..<<<...(((..[[.>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<<...<<<<<<<....>>>>>>>...>.>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<............<<<<<<<<<...<<<....<<<..<.<<<...<<<.<.<.....>.>.>>>.>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<..<...>.>>>>>>>>>...>>...>>>>>>>.>>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<............>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<...........]].)))..............................>>>>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<<<<<...>>>>>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<...<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<<<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>.>.>>>>>>>>>>>>.........>>>>>>>..>............>>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<...<<<<<<.>>>>>>........>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>>.<<<<<.......>>>>>.........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<<<<..>>>>>>>>>>...<<<<<.....<<<<..<<...>>..............<<<<<<<<<<<.....>>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>>.<<<....>>>.>>)))......<<<<<<<..<<<..)))))).>>>>>>>>>>.........>>>>..>>>>>>.......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<]]].>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>......<<<<<<.<<..<<<.....<<.........<<<<<..<<<<..>>>>.>>>>>........>>....<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>..............>>>..>>>>>>>>.<<<<<.<.............>....<<.<<<<<<<.<<.....<<<<....<<<<<......>>>>>...>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..(((((((((((.....)))))).))))....))))....((((((.((....((((((((.(......((((((((..({((((......)))))....[[(...).(((....}]])))...).)))))))..)))))))))...)).))))))..)....(((.(((........))).))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((......((((((((.....(((((((((((...(((.(..(((((.((..)))).)))..)...))).)))))))))))..........))).)))))..((((((((.((((.(((((.(((....(...(.((((.((((......(((((()))))).......)))).))))).........).)))...))))).))))....................(((((..((((((...))))))..((..(.((((..(((((((((((((((((((((((.((((....)))).)))))))))).))))))))))).))....).)))...).)..)......)))))......))).)))))....)))...)))))))).[((((........))))((((((....(((((((((((((..(((..(((((........)))).)...)))...((....))...((((((((....))))))))..(((((...(((..(((...[[[....[)))..)))....))))).(((((((((.((((......))))))))))).))....)))))))))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((..........(.((((((((....(((....(((..(.(((..(.((.(.(.....)..)))).))).)..)))..)).)....))))))...(((((((((........)))))))))...)).).)))))))..))..((((.((.((.....)).)).))))....(((......)))...(((((((...((([[[.....(.(((((......(..........(((.((((((((..............)))))))))))..........]]].)....)))))).)))...)))))))((((((.(((..........]...]]]..............................)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...((..(.(((....))).....)....((.((((.(.((...)).).))))))......))....))...(((((........)))))]]((((....(((.....(((((((....)))))))..((((....)))...(...((((((...((((((((((((((((((((((...{{{...)))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...))............))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((...((((((.))))))........)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(..(((.....((((....)))).....))))))))..)))))..(((.........)))..........((.(......).(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.(((((((((.((((((((((..))))))))))...(((((.....((((..((.()))..............(((((((((((.....)))))))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))).)..)).).)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a.))..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}}.)))))..)).))...))))...)))).((((...((((.............))))...))))..)))...).))))))......(((((..(...((......((..........((((..((((())))).)))).........))....((...(((....((((.(((((((......)))))))))))...)))...))...............))...).))))).(((((.(..(.......)..)....((.(((((((.((.....((((.(..(((((......)))))..)))))....))....)))).))).))..))))).. Structure of the ribosome-nascent chain containing an ER signal sequence in complex with NAC; 28S rRNA 7qwr 7 120 2.9 RF00001 URS000002B0D5_9986 35201867 0003735 0005840 9986 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<<............>>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. Structure of the ribosome-nascent chain containing an ER signal sequence in complex with NAC; 5S ribosomal RNA 7qwr 8 156 2.9 RF00002 URS00004B2C76_9986 35201867 0003735 0005840 9986 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<.<<.....>>>.....(.<<<......>>.............>>>..)...>>>....<<<..>>><<<<<<<<.......>>>>>>>>.................... .........................................((((((.[[....[)))...].(.(((......]].............)))..)...)))....((....))((((((((.......)))))))).................... Structure of the ribosome-nascent chain containing an ER signal sequence in complex with NAC; 5.8S ribosomal RNA 7qws 5 3493 3.4 RF02543,RF02540 URS00023358FA_9986 35201867 0003735 0005840 9986 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccgguucaacccggcggcggguccggccgugucggcgggucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucggccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcgcucuccccccucgggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccgggggaggggccacgcggcgagcgcacggggucggcggcgacgucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcacacgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcgugagccgggcguggaauggagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagagccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagcccgcccccggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcugggucggucgucggccggcgccuagcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacauguuuuuucacugacccggugaggcgggggggcgcucgcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccggucccccgcgggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcacgccguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<...<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>...<<<<<<<<<....<<<<<<<<.<......<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>..>>>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<......>>>..................................<<<<<<<<..<<<......<<<<<<<......<<<<<<<<<<<...<<<....<<<<<.<....>>>.>>>......>>>.>>>>>>>>>>>...........>>.>>>>>..<<<<<<<..<<<<<<<<<<.<<<..........<<<<.<<<<......<<<<<..>>>>>.......>>>>.>>>>............>>>...>>>>>>>>>>....................<<<<<..<<<<<<<.>>>>>>>..<.<<<.<<<<..<<<<<<<<<<<<<<<<<<<<<<<.<<<<....>>>>.>>>>>>>>>>.>>>>>>>>>>>.>>....>.>>>...>>>..>......>>>>>.......>>.>>>>>....>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<<....>>>>>>>>..<<<<<...<<<..<<<...(((..[[.>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<<...<<<<<<<....>>>>>>>...>.>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<............<<<<<<<<<...<<<....<<<..<.<<<...<<<.<.........>.>>>.>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<..<...>.>>>>>>>>>...>>...>>>>>>>.>>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<............>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<...........]].)))..............................>>>>>>>>>....>>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<<<<<...>>>>>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<...<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<<<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>.>.>>>>>>>>>>>>.........>>>>>>>..>............>>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<...............>>>>><<.<<<<<<<<<<<...<<<<<<.>>>>>>........>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>>.<<<<.........>>>>.........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<<<<..>>>>>>>>>>...<<<<<.....<<<<..<<...>>..............<<<<<<<<<<<.....>>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>>.<<<....>>>.>>)))......<<<<<<<..<<<..)))))).>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>........<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>.....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<]]].>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>......<<<<<<.<<..<<<.....<<.........<<<<<..<<<<..>>>>.>>>>>........>>....<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>..............>>>..>>>>>>>>.<<<<<.<.............>....<<.<<<<<<<.<<.....<<<<.<..<<<<<......>>>>>..>>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..(((((((((((.....)))))).))))....))))....(((((((((....((((((((.(......((((((((..({((((......)))))....[[(...).(((....}]])))...).)))))))..)))))))))...)))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.(....((((((((.....(((((((((((...(((.(..(((((.((..)))).)))..)...))).)))))))))))..........))).)))))..((((((((.((((.(((((.(((....(...(.((((.((((.......((((()))))........)))).))))).........).)))...))))).))))....................(((((..((((((...))))))..((.((.((((..(((((((((((((((((((((((.((((....)))).)))))))))).))))))))))).))....).)))...)))..)......)))))......))).)))))...))))...)))))))).[((((........))))((((((....(((((((((((((..(((..(((((........)))).)...)))...((....))...((((((((....))))))))..(((((...(((..(((...[[[....[)))..)))....))))).(((((((((.((((......))))))))))).))....)))))))))))))..((.(...((((((.....(((((((((..((((....((((((....))))))....)<)))...(((..((.((.......A)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((..........(.((((((((....(((....(((..(.(((..(.((.(.(.....)..)))).))).)..)))..)).)....))))))...(((((((((........)))))))))...)).).)))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[.....(.(((((......(..........(((.((((((((..............)))))))))))..........]]].)....)))))).)))...)))))))((((((.(((..........]...]]]..............................)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...((..(.(((....))).....)....((.((((.((((...)))).))))))......))....))...(((((........)))))]]((((....(((.....((.((((....)))).))...(((....)))...(...((((((...((((((((((((((((((((((...{{{...)))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...).............))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((...((((((.))))))........)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(..(((.....((((....)))).....))))))))..)))))..(((.........)))..........((.(......).(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.(((((((((.((((((((((..))))))))))...(((((.....((((..((.()))..............(((((((((((.....)))))))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))).)..)).).)........(.((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))..).....(((((((....))).))))..a.))..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}}.)))))..)).))...))))...)))).((((...((((.............))))...))))..)))...).))))))......(((((..(...(((.....((..........((((..((((())))).)))).........))....((...(((....((((.(((((((......)))))))))))...)))...))..............)))...).))))).(((((.(..(.......)..)....((.(((((((.((.....((((.(..(((((......)))))..)))))....))....)))).))).))..))))).. Structure of ribosome translating beta-tubulin in complex with TTC5 and NAC; 28S rRNA 7qws 7 120 3.4 RF00001 URS000002B0D5_9986 35201867 0003735 0005840 9986 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<<............>>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. Structure of ribosome translating beta-tubulin in complex with TTC5 and NAC; 5S rRNA 7qws 8 156 3.4 RF00002 URS00004B2C76_9986 35201867 0003735 0005840 9986 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<.<<.....>>>.....(.<<<......>>.............>>>..)...>>>....<<....>><<<<<<<<.......>>>>>>>>.................... .........................................((((((.[[....[)))...].(.(((......]].............)))..)...)))....((....))((((((((.......)))))))).................... Structure of ribosome translating beta-tubulin in complex with TTC5 and NAC; 5.8S rRNA 7r0e M 18 2.51 36596301 11320 aucuauaauaguuunuuc .................. .................. Early transcription elongation state of influenza A/H7N9 polymerase backtracked due to double incoproation of nucleotide analogue T1106 and with singly incoporated T1106 at the +1 position; mRNA 7r0e R 18 2.51 URS00026177BE_11320 36596301 11320 accucugaauaaacuauu .................. .................. Early transcription elongation state of influenza A/H7N9 polymerase backtracked due to double incoproation of nucleotide analogue T1106 and with singly incoporated T1106 at the +1 position; 3' vRNA 7r0e V 14 2.51 URS000080E200_11320 36596301 11320 aguaguaacaagag .<<....>>..... .((....))..... Early transcription elongation state of influenza A/H7N9 polymerase backtracked due to double incoproation of nucleotide analogue T1106 and with singly incoporated T1106 at the +1 position; 5' vRNA 7r1f R 12 2.58 URS00026177BA_11520 36596301 11520 gagaaagcuauu ............ ............ Early transcription elongation state of influenza B polymerase backtracked due to double incoproation of nucleotide analogue T1106; 3' vRNA 7r1f M 20 2.58 36596301 11520 aucuauaauagcuuucucnn .................... .................... Early transcription elongation state of influenza B polymerase backtracked due to double incoproation of nucleotide analogue T1106; mRNA 7r6l A 343 2.85 RF00028 URS00023358E6_5911 35501384 0000372 5911 cggguggagggaaaaguuaucaggcaugcaccugguagcuagucuuuaaaccaauagauugcaucgguuuaaaaggcaagaccgucaaauugcgggaaaggggucaacagccguucaguaccaagucucaggggaaacuuugagauggccuugcaaaggguaugguaauaagcugacggacaugguccuaaccacgcagccaaguccuaagucaagcuugauauggaugcaguucacagacuaaaugucggucggggaagaucuucucauaagauauagucggaccucuccuuaaugggagcuagcggaugaagugaugcaacacuggagccgcugggaacua ..............<<<<<<<<<<..(((.>>>>>>>>>>.<<<<<<<<<<<......<<<<<<.>>>>>.>>>>>>..<<<<<.<....<<<<<<...<<<<<<.....<<<.<<<<.<<...<<<<<<<<<....>>>>>>>>>..<<..)))..>>.....>>......>>>>>>>....>>>>>>..>>.>>>><<...<<<<...<<<<<..>>>>>..>>>>...>>.....(((((...>.>>>>>.<<<<<<..>>>>>>........)))))......<<<<<....>>>>><<<<<<<.(..<<<<>>>>>>>>>>...)>>>>>>>...... ..............((((((((((..{{{.)))))))))).(((((((((((....(.[[[[[[)))))).))))))..(((((.(....((((((...((((((.....(((.((((.(((..(((((((((....)))))))))..((..}}.}.))....)))......)))))))....))))))..)).))))((...((((..((((((()))))).)))))...))...[.[[[[[...).))))).((((((()))))))........]]]]]].....(((((....)))))(((((((....((((]]]]]]))))....)))))))...... 5 prime exon-free pre-2S intermediate of the Tetrahymena group I intron, symmetry-expanded monomer from a synthetic dimeric construct; Group I intron, 5 prime fragment 7r6l B 23 2.85 URS00023358F5_5911 35501384 5911 uuaguuuuggaguacucgacccg ....................... ....................... 5 prime exon-free pre-2S intermediate of the Tetrahymena group I intron, symmetry-expanded monomer from a synthetic dimeric construct; Group I intron, 3 prime fragment plus 3 prime exon 7r6m A 356 3.68 RF00028 URS00023358E9_5911 35501384 0000372 5911 uggagggaaaaguuaucaggcaugcaccugguagcuagucuuuaaaccaauagauugcaucgguuuaaaaggcaagaccgucaaauugcgggaaaggggucaacagccguucaguaccaagucucaggggaaacuuugagauggccuugcaaaggguaugguaauaagcugacggacaugguccuaaccacgcagccaaguccuaagucaagcuugauauggaugcaguucacagacuaaaugucggucggggaagaucuucucauaagauauagucggaccucuccuuaaugggagcuagcggaugaagugaugcaacacuggagccgcugggaacuauaguuuuggaguacucg ..........<<<<<<<<<<..(((.>>>>>>>>>>.<<<<<<.<<<<........<<<<.>>>>..>>>>>>..<<<<<.<....<<<<<<...<<<<<<.....<<<..<<..<<...<<<<<<<<<....>>>>>>>>>..<<..)))..>>.....>>.......>>.>>>....>>>>>>..>>.>>>><<...<<<<...<.<<<..>>>.>..>>>>...>>.....(((((...>.>>>>>.<<<<<<..>>>>>>........))))).((((.<<<<<....>>>>><<<<<<<.(..<<<.>>>>...>>>...)>>>>>>><<<<<<>>>>>>.)).....)). ..........((((((((((...{{.)))))))))).((((((...((....(....[[[)))....))))))..(((((.(....((((((...((((((.....(((.(..(.(((..((((((..(....)..))))))..((..}}...))....)))......)..))))....))))))..)).))))((...((((......((())).....))))...))...[.[[[[[...).))))).((((((()))))))........]]]]]]((((.(((((....)))))(.(((((.....((.]]]....)).....))))).)(((((()))))).)).....)). Post-2S intermediate of the Tetrahymena group I intron, symmetry-expanded monomer from a synthetic dimeric construct; Group I intron 7r6q 6 87 2.98 URS000261775E_1247190 36482249 1247190 ccuucucaaacauucuguuugguagugagugauacucuuuggaguuaacuugaaauugcuggccuuuaggcgaacaauguucuuaaa ......<<<<<<...>>>>>>.....<<<<...<<<<....>>>>..>>>>..........<<<<..>>>>................ ......((((((...))))))....(((((...((((....))))..))))..).......((((..))))................ State E2 nucleolar 60S ribosome biogenesis intermediate - Foot region model; ITS-2 7r6q 1 295 2.98 RF02543 URS000261776C_1247190 36482249 0003735 0005840 1247190 guuugaccucaaaucagguaggaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggguuuguaaagugccuucgaagagucgcuaagugggugguccaucuaaagcuaauagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccuuccggaaccuggauauggauucuucacacugaauguggagaaaauccacaggaaggaauaguuuucaugccaggucgua .........................<<<..<........<<.<<<<<<...>>>>>>.>>........>....<<<<<<<.<<<<<..>....>>>>>>>>>>>...............<<<<<<.>>>>>>..>>>.....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<....>>>))<<<<.<<<<<<..............<<<<<<.....>>>>>>............>>.>>>>>>>>>>>>.. .........................((((.........(((.((((((...)))))).))....)........(((((((.(((((..)....)))))))))))...)....().....((((((.))))))..))).....[[(((.((...((....(((....)))........((((((........))))))....))....))...(((....)))]]((((.((((((.....(....(...((((((.....))))))...)).......)).)))))))).))).. State E2 nucleolar 60S ribosome biogenesis intermediate - Foot region model; 25S rRNA 7r6q 2 57 2.98 RF00002 URS0002617757_1247190 36482249 0003735 0005840 1247190 ugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .....<<<...>>><<<<<<<<<....>>>>>>>>>..................... .....((.....))(((((((((....)))))))))..................... State E2 nucleolar 60S ribosome biogenesis intermediate - Foot region model; 5.8S rRNA 7r72 1 641 3.07 RF02543 URS0002617762_1247190 36482249 0003735 0005840 1247190 augccugaauagggugaagccagaggaaacucugguggaggcucgcgaauuuggguauaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagaugguuucaaaggccugauucaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugucuccaaggugaacagccucuaguugauagaauccguaacuucgggauaaggauuggcucuaagggucggguagugagggccuuggucacggccuuggcuugcuacaauuaacgaucaacuuagaacugguacggacaauaucuagcgaggcugucugaucaggcauugcguaagcaguagaguagccguuacgaucugcugaga <<<<<<<<...<<<....<<<<<<<....>>>>>>>.....>>>......>>>>>>>>....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<............<<<<<<...>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<......<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..(((..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>............>>.>>>>>>>>>>>>..>>.>>>>>.<<<<.....>>>>..>>>>..<<<<.<<<<<<.<<<<.....................<<<<<.<<<<<<<<..<<..<<<<..>>>>..>>>>>>>>>>......>>>>>......>>>...>>>>>>>.....>>>>>>...<<<<<<<))).>>>>>..>>....<<<<....<<.......>>...>>>>..... ((((((((...((((...(((((((....)))))))...).)))......))))))))....((.....((((((.......))))))((((.....(((((.((...((((((...((.....)).))))))....[[(((.((...((............((((((...))))))....))....))...(((((........)))))]]((((..(((((.....((((....)))...(...((((((...((((.((((((((((((((((((..[[[..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...)).......)).))).)))).)))..)).))))).((((.....))))..))))..((((.(.((((.(.((.....................(((((.((((.(((..((..((((..))))..))))).))))......)))))......))...).)))).).....))))))...(((((((]]].)))))..))....((((....((.((.)).))...))))..... State E1 nucleolar 60S ribosome biogenesis intermediate - Spb4 local model; 25S rRNA 7r72 2 59 3.07 RF00002 URS0002617755_1247190 36482249 0003735 0005840 1247190 gaacgcgcgauacucuuugaacgcacauugcgccccuugguauuccagggggcaagcgu <<<<<..>>......>>>....<<.....>><<<<<<<<<....>>>>>>>>>...... (((((()))......)))....((.....))(((((((((....)))))))))...... State E1 nucleolar 60S ribosome biogenesis intermediate - Spb4 local model; 5.8S rRNA 7r7a 1 2571 3.04 RF02543 URS000261776E_1247190 36482249 0003735 0005840 1247190 guuugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaugguguuuugugcccucugcuccuuguggguaggggaaucucgcauuucacugggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucggcggucgaucgucgaauuuggguauaggggcgaaagacaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugaauguaagaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacuucuccaaggugaacagccucuaguugauagaauuccguaacuucgggauaaggauuggcucuaagggucggguagugagggccuuggucacggccuuggcuugcuacaauuaacgaucaacuuagaacugguacggacaauaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaacccuguugagcuugacucuaguuugacauugugaagagacauagaggguguagaauaagugggagcuucggcgccagugaaauaccacuaccuuuauaguuucuuuacuauugucagguggggaguaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuccuaucauaccgaagcagaauucgguaagcguuggacccacuaauagggaacggaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccguuacgaucugcugagauuaagccuuuguugucugauuugu ..........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..<<<..<........<<.<<<<<<...>>>>>>.>>........>....<<<<<<<.<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....<<<<<<..>>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<.....<<<<<....<<..<<<<<<<<.......>>>>>>>>......>>....>>>>>.<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<......>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<.......>>>.>>>.>>....>>>>>>.>>>>>>..<<.<...<<<<<<...<<<<<<<<<<...<<<....<<<<<<<....>>>>>>>.....>>>.<<<<....>>>>.....>>>>>>>>>>...<....>...>>>>>>......>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<....>>>>.>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>>..<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<......<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..(((..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>............>>.>>>>>>>>>>>>..>>>>>>>.<<<<.....>>>>..>>>>..<<<<..<<<<<<.<<<<.....................<<<<<.<<<<<<<<..<<..<<<<..>>>>..>>>>>>>>>>......>>>>>......>>>...>>>>>>>.....>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<..<<<<<<.<<<<<<..<<<<.<<<<.<<...<<<<<<<<<<..<<<<<..........<<<<<..<<....>>............>>>>>.>>>>>...>>>>>>>>>>....>>.>>>>..>>>>..>>>>>.>.>>>>>>.............<<<<<<...<<.......>>...>>>>>>.<<<<..<.<<<<<<<......>>>>>>>...>.<<<..>>>.....>>>>....<<<<<<<....>>>.>>>>........>>>.>>>>>....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<....<<<<<<<<<<))).>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<.....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>..............>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<.....>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ..........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........(((((((.((((((.(((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))).))....)))))))))))...)....(((((((........))))))).....((((((..))))))..)))..................................((....))............(..((((....))))............).....................(((((.(((((......((((........((.((.(..(....).).)).))............))))..(((((((((((((((((((((((.......(((((((......(((((......))))).......))))))).....))))).))))))))))........(((....)))....)))))))).....))))).)))))..((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).(((...((.......))....).))....)))))).))))))..((.(...((((((....(((((((((...((((...(((((.(....).)))))...).)))..((((..))))......)))))))))..(.(....).).))))))......).))).((((((......(((....)))..((((((((((....((.((((((....)))).))))..)))))))).))..((((.((.((.....)).)).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))((((((((...........))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....(((((.((...((((((...((.....)).))))))....[[(((.((...((....(((....)))........((((((........))))))....))....))...(((((........)))))]]((((..(((((.....((((....)))...(...((((((...((((.((((((((((((((((((...[[..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...)).......)).))).)))).)))..))))))).((((.....))))..))))..((((..(.((((.(.((.....................(((((.((((.(((..((..((((..))))..))))).))))......)))))......))...).)))).).....))))))....)).[..(((((......].)))))....(((((..(((..((((((.((((((..((((.(..(..(...(....((.(((.(((.((..........((((..((....))............))))..))))).).)).))....)....)...).)..))))..))))).).)))))).............((((((...((.......))...))))))(((((..(.((((((........)))))..).).(((..))).....)))))...(((.(((....)))..)))........))).))))).....(((((((..((((.(..((((......(....).....))))..)(((((...((((....((((((((((]]..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))........((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...((.((.(..(((......)))..).)).)).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((....((.......))...))))...)))....)))).)))))).))))).. State E1 nucleolar 60S ribosome biogenesis intermediate - Composite model; 25S rRNA 7r7a 2 158 3.04 RF00002 URS00001BF64E_1247190 36482249 0003735 0005840 1247190 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... State E1 nucleolar 60S ribosome biogenesis intermediate - Composite model; 5.8S rRNA 7r7a 6 87 3.04 URS000261775E_1247190 36482249 1247190 ccuucucaaacauucuguuugguagugagugauacucuuuggaguuaacuugaaauugcuggccuuuaggcgaacaauguucuuaaa ......<<<<<<...>>>>>>.....<<<<...<<<<<..>>>>>..>>>>..........<<<<..>>>>................ ......((((((...))))))....(((((...((((....))))..))))..).......((((..))))................ State E1 nucleolar 60S ribosome biogenesis intermediate - Composite model; 5.8S ribosomal RNA gene and internal transcribed spacer 2 7r81 A1 3123 2.7 RF02540,RF02543 URS0002311989_5141 34815343 0003735 0005840 5141 uugaccucggaucagguaggaauacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaacagggauugcccuaguaacggcgagugaagcggcaacagcucaaauuugaaaucuggcuucggcccgaguuguaauuuguagaggaagcuuuuggugaggcaccuucugaguccccuggaacggggcgccauagagggugagagccccguauagucggaugccgauccaauguaaagcuccuucgacgagucgaguaguuugggaaugcugcucaaaaugggagguaaauuucuucuaaagcuaaauaccggccagagaccgauagcgcacaaguagagugaucgaaagaugaaaagcacuuugaaaagaggguuaaauagcacgugaaauuguugaaagggaagcguuugugaccagacuugcgccguuccgaucauccgguguucucaccggugcacucgggacggcucaggccagcaucgguuuuggcggggggauaaagguccggggaacguagcuccuccgggaguguuauagccccgggcguaaugcccucgccgggaccgagguucgcgcaucugcaaggaugcuggcguaauggucaucaacgacccgucuugaaacacggaccaaggagucaagguuuugcgcgaguguuuggguguaaaacccgcacgcguaaugaaagugaacguaggugagagcuucggcgcaucaucgaccgauccugauguauucggauggauuugaguaagagcguuaagccuuggacccgaaagauggugaacuaugcuuggauagggugaagccagaggaaacucugguggaggcucgcagcgguucugacgugcaaaucgaucgucaaaucugagcaugggggcgaaagacuaaucgaaccaucuaguagcugguuaccgccgaaguuucccucaggauagcaguguuguucuucaguuuuaugagguaaagcgaaugauuagggaccauucucaaacuuuaaauauguaagaagcccuuguuacuuaauugaacgugggcauucgaauguaccaacacuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacgcgggguuaaggugccggaguggacgcucaucagacaccacaaaaggcguuaguacaucuugacagcaggacgguggccauggaagucggaauccgcuaaggacuguguaacaacucaccugccgaauguacuagcccugaaaauggauggcgcucaagcgucccacccauaccccgcccucaggguagaaacgaugcccugaggaguaggcggccguggaggucagugacgaagccuagggcgugagcccgggucgaacggccucuagugcagaucuuggugguaguagcaaauacuucaaugagaacuugaaggaccgaaguggggaaagguuccaugugaacagcgguuggacauggguuagucgauccuaagccauagggaaguuccguuucaaaggggcagugccccguguggcgaaagggaagccgguuaacauuccggcaccuggauguggguuuugcgcggcaacgcaacugaacgcggagacgacggcgggggccccgggcagaguucucuuuucuucuuaacggucuaucacccugaaaacaguuugucuggagauaggguuuaauggccggaagagcccgacacuucugucggguccggugcgcucucgacgucccuugaaaauccgcgggagggaauaauucucacgccaggucguacucauaaccgcagcaggucuccaaggugaacagccucugguugauagaacaauguagauaagggaagucggcaaaauagauccguaacuucgggaaaaggauuggcucuaaggguuggacaaccaacuuagaacugguacggacagggggaaucugacugucuaauuaaaacauagcauugcgauggccagaaagugguguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaaaauuuuuuuacuuauucaauuaagcggggcuggauuuucguccaacuucugguuuuaagguccuucgcgggccgacccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaaccauaacgcagguguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaaguccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucgaaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaccucaucgcaaugguaauugagcuuaguacgagaggaaccgcucauucagauaauugguuuuugcgguuguccgaccgggcagugccgcgacgcuaccaucugcuggauaauggcugaacgccucuaagucagaauccaugccagaacgcgaugauaccuccagcacguuguagacguauaagaauaggcuccggccucguaucuuagcaggcgauuccuccguuggccuugaaguggccagcgguaauucgcguauuguaauuuuaacacgcgcuggaucaaauccuuugcagacgacuuagaugugcgaaaggguccuguaagcaguagaguagccuuguuguuacgaucugcugaggguaagcccuccuucgccuagauuu ........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..<<<..<<.......<<.<<<....>>>.>>.......>>....<<<<.<<<<<.<<<...<<<<<<..<<....<<<<......>>>>.((......<<<.....))>>>....>>..>>.>>>>...>>>.....>>>>>.>>>>........<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<.<<<<<<.....<<.<<<<<<<....<....<<....>>....>........>>>.>>>>.>>.<<<<<<<.<<<<<<<<<<<<<<<.....<.<<<<<<<<......<<<<<....>>>>>.......>>>>>>>>....>.>>>>>>>>>>>>>>>........<<<..>>>.....>>>>>>>.....>>>>>>.>>>>..<<<<........>>>><<<<<<....<<<<<<<<.<<<<..<<<..<<<<<.....>>>>>..>>>...<<....>>.......<<<<<..<<....>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>.>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>...<<<<<....<.<<<....>>>.><<<<<<<<<.....<<.<<<<<<<.....<<<....<<<..<.<<.>>.>..>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>...>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<......<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<........>...>>>>>...>>>>>>>>>>>>>..........))).>....>>>>>>.>>>...>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<...<<<....>>>........<<<<<<.>>>>>>....>>>....>>...<<<<<........>>>>>))<<<<.<<<<.<<<....<<<....>>>......(<<<<<<...<<<<.<<<<<<<<<<<<<.<<<<.......>>>>.><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<<....>>>>>>>>>>>>.>.>>>>>>>.>>>>.........>>>>>>.........>>>...>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<..>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<....<<<<<....>>>>.>...>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<..<<<<<<....>>>>>>...<<<<<.....<<<<..<<<<......>>>>..........)...<<<<<.....>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))......<<<<<<<..<<<<.))))))>>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>....<<<<<<<..<<<<.<.<<<<<.................>>>>>.><<<<<...<<<<....<<<<<<<<<<....>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>....<<<<<<.<<<.<<......<<.......<<<....>>>....>>........<<<<.....<<<<<<<<<.......>>>>>>>>>....>>>>..............>>>>>.>>>>>>..<<.<.<<.............>>....<.<<.<<<<.<<<....<<<<.<..<<<<<......>>>>>..>>>>>...>>>....>>>>..>>..>...>.>>. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.(((....))).))....)........((.(.(((((..((......(((..((..({((((......)))))[[(...).(((....}]])))....))..)).)......))......))))).).))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((.((((((.....((.((((..(....(................)........)...)))).)).((((((((((((((((.(..(((.......(((.((((......(((((....))))).......)))).)))......)))..).))))))))........((....))....)))))))).....)))))).)))).{((((........))))((((((....((((((((.((((..(((...(((.......)))...)))...((....)).......(((((..((....))...))))).((((((((....(....)....))).))).))....)))).))))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...){)))...(((..((.((.......A)))).)))....))))))))).(.((.......))...)..))))))......).))...(((((....(.(((....))).)(((((((((.....((.(((((((.....(((....(((..(.((.)).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))...))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....<.(..((..(....((.........))....)......(....(......)..).))..)...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...((((((...((.....)).))))))....[[(((.((...(((...(((....)))........(.((((.)))).)....)))....))...(((((........)))))]]((((..(((.(((...((((....)))...(.[[((((((...((((.(((((((((((((.((((.......)))).)(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....)))...))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((.((....)).)..)))))).))(...).......(((((((((.}.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.....((.....((((....)))).....))..))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....}].)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((.(...))))))...(((((.....((((..(((........)))..........]]..(((((.....)))))..))))..))))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a.))..))).)))))....(((((((..(((.....((........(....).......))....((((.....(.....(..(..(..(....)..)....)..)....)....))))..(..(...(..(.....>.......)..)...)..)..)))....)))))))....((((((.(((.((....(.((.......(((....)))....))).......((((.....((.(...((.......))...).))....))))..............))))).))))))..((...((..(.......)..))..(....(.((((.(((....((((.(..((((((..)..)))))..)))))...)))....))))..)...).....)). Structure of the translating Neurospora crassa ribosome arrested by cycloheximide; 26S rRNA 7r81 A2 1769 2.7 RF01960,RF01959,RF00177 URS00001F2ABC_5141 34815343 0003735 0005840 5141 uaccugguugauucugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguuuaagcaauuaaaccgcgaaacugcgaauggcucauuaaaucaguuauaguuuauuugauaguaccuuacuacauggauaaccgugguaauucuagagcuaauacaugcuaaaaaccccgacuucagggguguauuuauuagauuaaaaaccaaugcccuucggggcuaacuggugauucauaauaacuucucgaaucgcauggccuugcgcuggcgaugguucauucaaauuucugcccuaucaacuuucgacggcugggucuuggccagccauggugacaacggguaacggaggguuagggcucgaccccggagaaggagccugagaaacggcuacuacauccaaggaaggcagcaggcgcgcaaauuacccaaucccgacacggggagguagugacaauaaauacugauacagggcucuuuugggucuuguaauuggaaugaguacaauuuaaaucccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugagguuaaaaagcucguaguugaaccuugggcucggcccgucgguccugggucgggccuuuccuggagaaccgcaugcccuucacugggugugucggggaaccaggacuuuuaccgugaacaaaucagaucgcucaaagaaggccuaugcucgaauguacuagcauggaauaauagaauaggacgugugguucuauuuuguugguuucuaggaccgccguaaugauuaauagggacagucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggauguuuucauuaaucaggaacgaaaguuaggggaucgaagacgaucagauaccgucguagucuuaaccauaaacuaugccgauuagggaucggacgguguuauuuuuugacccguucggcaccuuacgauaaaucaaaauguuugggcuccugggggaguauggucgcaaggcugaaacuuaaagaaauugacggaagggcaccaccagggguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacgaugaggauugacagauugagagcucuuucuugauuucgugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccugcuaaauagcccguauugcuuuggcaguacgcuggcuucuuagagggacuaucggcucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagauguucugggccgcacgcgcgcuacacugacacagccagcgaguacucccuuggccggaagguccggguaaucuuguuaaacugugucgugcuggggauagagcauugcaauuauugcucuucaacgaggaaucccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuacuaccgauugaauggcucagugaggcuuccggacuggcccagggaggucggcaacgaccacccagggccggaaagcuauccaaacucggucauuuagaggaaguaaaagucguaacaaggucuccguuggugaaccagcggagggaucauu ...<<<<<.[.((((>>>>><<<<.<<<<<<...<.<...<......<<<.<<<..<<....<<<...<<.........>>..>>>.>>......<<........<<<..<<..<<....<<<...............<<.....<..<<<.....>>>..>......>>........<<<<<.......>>>>><...<<<<<<......[.......<<<<....>>>>..............>>>>>>.....>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<......<<<<<<.......>>>>>>..>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<<..>>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>....>.>....<<<<.<<<<<<..........>>>>>>..>>>>.....<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>>.........<<<((.....<.<<...<<<.<<....<<<<<<<<<<<<.......>>>>>>>>>>>>..<<<.......................................>>>....<<<<<<<<.......<<..<<.......>>.<<<....>>>....>>......>>>>>..>>>.........<<<.<<<<<<<<<...........].>>>>>>>>>>>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<<.....>>>>>>>>>>>>..>>>...<<..))>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<.<<<<<<..<<<..<<<........<<........>>..........<<<<<<.....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<..<<<..........>>>....>>>>..>>>>.>>....<<<<<<....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>.....>>>.>>>......>>>..>>>.....<<<<<<<......<<.....<<<.<<<<....>>>>.>>>....>>.......>>>>>>>......<....<<<<<<..........>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<.<..<...<<<<<<<.<<<.<<<<<....>>>>>.>>>.>>>>>>>...>..>.>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>........ ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((.........))...))[))......(((.......(((..((..((....(((...............((.....(..(((.....)))..)......))........(((((.......)))))(.(.((((((......{.....{.((((....)))).....(......).)))))).)...).(.((((.(((((..).)))))))))...)))...))))..))).(((....(((....(.((((((.......)))))).))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)....).)....(((..(((((.(.(....).).)))))...)))...(.(.(.(...........))..)......)..((((([[....(.((((.....((..]])).......))))))))))..))))))))))..[......((([[...(.(.((...(((.((....((((.((.(((.........))).)).))))..(((.(......(.....................).......))))....((((((((.......((..((.......)).(((....)))....))......)))))..))).........(...(((((((((.....}.....}.)))))))))..).....))...(((.(((.((...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)).)))..))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..((((((((.((((.....))))))))))))..)))...((..]]))...))...].))))))).(((......((((....))))....)))...]]].].((((.(((((((..((..(((((.......((.........((........))..........(..(((.....(((((........((.(((........))).))......)))))...((.(((...(.((((((.(..(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..((((.((((..(....)..)))..).))))..)))).))..(.((((((....))))))....)..))))).)..))).))).....).))))).....)))...).......))......(...(((((((......((.....(((.((((....)))).)))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).)...(.(..((.(..((((.((..(.((((((((.(((..((.(..(...(((((((.(((.(((((....))))).))).)))))))...)..).))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}....... Structure of the translating Neurospora crassa ribosome arrested by cycloheximide; 18S rRNA 7r81 B1 120 2.7 RF00001 URS00002B3C45_5141 34815343 0003735 0005840 5141 acauacgaccauacccacuggaaaacucgggaucccguccgcucucccauagauaagccagugagggccagacuaguaguugggucggugacgaccagcgaaucccugguguuguauguu <<<<<<<<<....<<<<<<<<.....<<<<<<............>>>>...>>....>>>>>>.>><<<<<.......<<<<<..<<....>>.>>>>>......>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))))...))....)))))).))(((((.......(((((..((....)).)))))......)))))))))))))). Structure of the translating Neurospora crassa ribosome arrested by cycloheximide; 5S rRNA 7r81 C1 158 2.7 RF00002 URS00001EBF7E_5141 34815343 0003735 0005840 5141 aaacuuucaacaacggaucucuugguucuggcaucgaugaagaacgcagcgaaaugcgauagguaaugugaauugcagaauucagugaaucaucgaaucuuugaacgcacauugcgcucgccaguauucuggcgagcaugccuguucgagcgucauuu .........................................<<<<<<<<<....>>>>.....<.<<<......>>..............>>>..>...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Structure of the translating Neurospora crassa ribosome arrested by cycloheximide; 5.8S rRNA 7r81 t1 76 2.7 RF00005 URS0000E60BDA_5141 34815343 0030533 0006412 5141 uuccucguggcccaauggucacggcgucuggcuacgaaccagaagauuccagguucaaguccuggcggggaagcca <<<<<<<..<<<..........>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... ((((.((..(((.....[....))).(((((.......))))).....(((((..]....))))))).)))).... Structure of the translating Neurospora crassa ribosome arrested by cycloheximide; tRNA 7r81 u1 76 2.7 RF00005 URS0000E60BDA_5141 34815343 0030533 0006412 5141 uuccucguggcccaauggucacggcgucuggcuacgaaccagaagauuccagguucaaguccuggcggggaagcca <<<<<<<..<<<..........>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... ((((.((..(((.....[....))).(((((.......))))).....(((((..]....))))))).)))).... Structure of the translating Neurospora crassa ribosome arrested by cycloheximide; tRNA 7r81 w1 17 2.7 34815343 5141 uuuuuuuuuuuuuuuuu ................. ................. Structure of the translating Neurospora crassa ribosome arrested by cycloheximide; mRNA 7r97 C 28 1.804 URS000080DE20_562 35829618,30916338 562 aaaggucauucgcaagaguggccuuuau <<<<<<<<<<<....>>>>>>>>>>>.. (((((((((((....))))))))))).. Crystal structure of postcleavge complex of Escherichia coli RNase III; RNA (28-MER) 7r97 D 28 1.804 URS000080DE20_562 35829618,30916338 562 aaaggucauucgcaagaguggccuuuau <<<<<<<<<<<....>>>>>>>>>>>.. (((((((((((....))))))))))).. Crystal structure of postcleavge complex of Escherichia coli RNase III; RNA (28-MER) 7r9f B 13 2.89 URS00023119C6_32630 37939088 32630 naaucgggauucc ............. ............. Wild-type yeast Pseudouridine Synthase, PUS1, bound to 5-Fluorouracil RNA; RNA (5'-R(*UP*AP*AP*UP*CP*GP*GP*GP*AP*UP*UP*CP*CP*GP*GP*AP*UP*A)-3') 7r9g B 12 2.4 URS0002311987_32630 37939088 32630 aaaucgggauuc ............ ............ Catalytically inactive yeast Pseudouridine Synthase, PUS1, bound to RNA; RNA (5'-R(*AP*AP*AP*UP*CP*GP*GP*GP*AP*UP*UP*CP*CP*GP*GP*AP*UP*A)-3') 7rdx P 34 3.1 URS00021ED921_32630 35260847 32630 gcguagcaugcuacgucauucuccuaagaagcua .................................. .................................. SARS-CoV-2 replication-transcription complex bound to nsp13 helicase - nsp13(2)-RTC - open class; Product RNA 7rdx T 46 3.1 RF03125 URS00021ED933_32630 35260847 0039694 32630 augugauuuuaauagcuucuuaggagaaugacguagcaugcuacgc .............................................. .............................................. SARS-CoV-2 replication-transcription complex bound to nsp13 helicase - nsp13(2)-RTC - open class; Template RNA 7rdy P 34 3.1 URS00021ED921_32630 35260847 32630 gcguagcaugcuacgucauucuccuaagaagcua .................................. .................................. SARS-CoV-2 replication-transcription complex bound to nsp13 helicase - nsp13(2)-RTC - engaged class; Product RNA 7rdy T 44 3.1 URS00021ED933_32630 35260847 32630 cccauguuaauagcuucuuaggagaaugacguagcaugcuacgc ............................................ ............................................ SARS-CoV-2 replication-transcription complex bound to nsp13 helicase - nsp13(2)-RTC - engaged class; Template RNA 7rdz P 34 3.6 URS00021ED921_32630 35260847 32630 gcguagcaugcuacgucauucuccuaagaagcua .................................. .................................. SARS-CoV-2 replication-transcription complex bound to nsp13 helicase - nsp13(2)-RTC - apo class; Product RNA 7rdz T 37 3.6 URS00021ED933_32630 35260847 32630 uaauagcuucuuaggagaaugacguagcaugcuacgc ..................................... ..................................... SARS-CoV-2 replication-transcription complex bound to nsp13 helicase - nsp13(2)-RTC - apo class; Template RNA 7re0 P 34 3.5 URS00021ED921_32630 35260847 32630 gcguagcaugcuacgucauucuccuaagaagcua .................................. .................................. SARS-CoV-2 replication-transcription complex bound to nsp13 helicase - nsp13(2)-RTC - swiveled class; Product RNA 7re0 T 37 3.5 URS00021ED933_32630 35260847 32630 uaauagcuucuuaggagaaugacguagcaugcuacgc ..................................... ..................................... SARS-CoV-2 replication-transcription complex bound to nsp13 helicase - nsp13(2)-RTC - swiveled class; Template RNA 7re1 P 34 2.91 URS00021ED921_32630 35260847 32630 gcguagcaugcuacgucauucuccuaagaagcua .................................. .................................. SARS-CoV-2 replication-transcription complex bound to nsp13 helicase - nsp13(2)-RTC (composite); Product RNA 7re1 T 37 2.91 URS00021ED933_32630 35260847 32630 uaauagcuucuuaggagaaugacguagcaugcuacgc ..................................... ..................................... SARS-CoV-2 replication-transcription complex bound to nsp13 helicase - nsp13(2)-RTC (composite); Template RNA 7re2 P 34 3.17 URS00021ED921_32630 35260847 32630 gcguagcaugcuacgucauucuccuaagaagcua .................................. .................................. SARS-CoV-2 replication-transcription complex bound to nsp13 helicase - nsp13(1)-RTC; Product RNA 7re2 T 37 3.17 URS00021ED933_32630 35260847 32630 uaauagcuucuuaggagaaugacguagcaugcuacgc ..................................... ..................................... SARS-CoV-2 replication-transcription complex bound to nsp13 helicase - nsp13(1)-RTC; Template RNA 7re3 P 34 3.33 URS00021ED921_32630 35260847 32630 gcguagcaugcuacgucauucuccuaagaagcua .................................. .................................. SARS-CoV-2 replication-transcription complex bound to nsp13 helicase - nsp13(2)-RTC dimer; Product RNA 7re3 T 37 3.33 URS00021ED933_32630 35260847 32630 uaauagcuucuuaggagaaugacguagcaugcuacgc ..................................... ..................................... SARS-CoV-2 replication-transcription complex bound to nsp13 helicase - nsp13(2)-RTC dimer; Template RNA 7re3 Q 34 3.33 URS00021ED921_32630 35260847 32630 gcguagcaugcuacgucauucuccuaagaagcua .................................. .................................. SARS-CoV-2 replication-transcription complex bound to nsp13 helicase - nsp13(2)-RTC dimer; Product RNA 7re3 U 37 3.33 URS00021ED933_32630 35260847 32630 uaauagcuucuuaggagaaugacguagcaugcuacgc ..................................... ..................................... SARS-CoV-2 replication-transcription complex bound to nsp13 helicase - nsp13(2)-RTC dimer; Template RNA 7rq5 A 19 NA URS00023119D8_11320 34983822 11320 auccagaaacggauggaua <<<<<........>>>>>. (((((........))))). Hairpin near 3'-Splice Site of Influenza A Segment 7 Bound to 5-nt Oligonucleotide; RNA (5'-R(*AP*UP*CP*CP*AP*GP*AP*AP*AP*CP*GP*GP*AP*UP*GP*GP*AP*UP*A)-3') 7rq8 1A 2871 2.5 RF02540,RF02541,RF00002 URS00001698E8_300852 34707295 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<.....<<<........>>>......>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..<.......(......>>>>.........<<......>>.).>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<.......<<<<.<......>.>>>>....>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<...>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((..(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...((((((((.(..(((.(......).)..)))..))))))))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((..((.........))...))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((.((((((((.(......[..(((((..(((......(((((..........)))))...)))..........].)))))).)))))))).)))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..(((...)))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with iboxamycin, mRNA, deacylated A- and E-site tRNAs, and aminoacylated P-site tRNA at 2.50A resolution; 23S Ribosomal RNA 7rq8 1B 120 2.5 RF00001 URS000080DEE8_300852 34707295 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> (((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).))))))))))) Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with iboxamycin, mRNA, deacylated A- and E-site tRNAs, and aminoacylated P-site tRNA at 2.50A resolution; 5S Ribosomal RNA 7rq8 1a 1500 2.5 RF00177,RF01959,RF01960 URS000080DFED_300852 34707295 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<......>>....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((..)))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((((((....)))))))....(((....)))....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with iboxamycin, mRNA, deacylated A- and E-site tRNAs, and aminoacylated P-site tRNA at 2.50A resolution; 16S Ribosomal RNA 7rq8 1v 13 2.5 34707295 10665 aaaaauguucuaa ............. ............. Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with iboxamycin, mRNA, deacylated A- and E-site tRNAs, and aminoacylated P-site tRNA at 2.50A resolution; mRNA 7rq8 1w 71 2.5 RF00005 URS00005AA258_562 34707295 0030533 0006412 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggca <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>. (((((((..((((...[..)))).((((.........)))).....(((((..]....)))))))))))). Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with iboxamycin, mRNA, deacylated A- and E-site tRNAs, and aminoacylated P-site tRNA at 2.50A resolution; A-site tRNA 7rq8 1x 76 2.5 RF00005 URS000041AF00_562 34707295 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaaccn <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with iboxamycin, mRNA, deacylated A- and E-site tRNAs, and aminoacylated P-site tRNA at 2.50A resolution; P-site tRNA 7rq8 1y 74 2.5 RF00005 URS00005AA258_562 34707295 0030533 0006412 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[..)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with iboxamycin, mRNA, deacylated A- and E-site tRNAs, and aminoacylated P-site tRNA at 2.50A resolution; E-site tRNA 7rq8 2A 2800 2.5 RF02540,RF02541,RF00002 URS00001698E8_300852 34707295 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<....<<<<........>>>.>....>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<..>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<..>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<.......<<<<<<<<....>>>>>>>>....>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....(())....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..((.((((((...(((...(.(.((((....(((..........)).)....)))).).)..)).)...)))))).))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((.().)))))))).))..........]]].)....))))))))))...)))))))(((((.(..).)))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((.(((((((((.(......[..(((((...(.......((((((((....))))))))....)...........].)))))).))))))))).))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...((((...........)))).....((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(............(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))...)))) Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with iboxamycin, mRNA, deacylated A- and E-site tRNAs, and aminoacylated P-site tRNA at 2.50A resolution; 23S Ribosomal RNA 7rq8 2B 120 2.5 RF00001 URS000080DEE8_300852 34707295 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>. .((((((((((....((((((.(....(((((((...(.....)...))))..)))...).)))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with iboxamycin, mRNA, deacylated A- and E-site tRNAs, and aminoacylated P-site tRNA at 2.50A resolution; 5S Ribosomal RNA 7rq8 2a 1503 2.5 RF00177,RF01959,RF01960 URS000080DFED_300852 34707295 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggau .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<......>>....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((.(((((......((........))..........(((((((..(...(((((((...(((((((....)))))))....(.(....).)....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).))).)))).(...(((((((.....(((..(((.(.((....)).)).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with iboxamycin, mRNA, deacylated A- and E-site tRNAs, and aminoacylated P-site tRNA at 2.50A resolution; 16S Ribosomal RNA 7rq8 2v 13 2.5 34707295 10665 aaaaauguucuaa ............. ............. Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with iboxamycin, mRNA, deacylated A- and E-site tRNAs, and aminoacylated P-site tRNA at 2.50A resolution; mRNA 7rq8 2w 69 2.5 RF00005 URS00005AA258_562 34707295 0030533 0006412 562 cccgganagcucagggagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggca <<<<<<..<<<<.....>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>.. ((((((..((((...[.)))).((((.........)))).....(((((..]....))))))))))).. Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with iboxamycin, mRNA, deacylated A- and E-site tRNAs, and aminoacylated P-site tRNA at 2.50A resolution; A-site tRNA 7rq8 2x 76 2.5 RF00005 URS000041AF00_562 34707295 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaaccn <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with iboxamycin, mRNA, deacylated A- and E-site tRNAs, and aminoacylated P-site tRNA at 2.50A resolution; P-site tRNA 7rq8 2y 73 2.5 RF00005 URS00005AA258_562 34707295 0030533 0006412 562 gcccgganagcucagggagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<.....>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[.)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with iboxamycin, mRNA, deacylated A- and E-site tRNAs, and aminoacylated P-site tRNA at 2.50A resolution; E-site tRNA 7rq9 1A 2871 2.6 RF02540,RF02541,RF00002 URS00001698E8_300852 34707295 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacganaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>....<<<<<.....<<....>>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<....<<<..........>>..>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<..<<<......(..>...>>>>.........<<......>>.).>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<.......<<<<<<......>>>>>>....>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<...>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> ..(......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((..(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((..)))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((.(..(((..........)..)))..)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((..((..((.........))...))......(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((.((..((((((((.(.........(((((...((.......(((((((....)))))))....)).............)))))).))))))))..)).)))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..((.....))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....).. Crystal structure of the A2058-dimethylated Thermus thermophilus 70S ribosome in complex with iboxamycin, mRNA, deacylated A- and E-site tRNAs, and aminoacylated P-site tRNA at 2.60A resolution; 23S Ribosomal RNA 7rq9 1B 120 2.6 RF00001 URS000080DEE8_300852 34707295 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the A2058-dimethylated Thermus thermophilus 70S ribosome in complex with iboxamycin, mRNA, deacylated A- and E-site tRNAs, and aminoacylated P-site tRNA at 2.60A resolution; 5S Ribosomal RNA 7rq9 1a 1500 2.6 RF00177,RF01959,RF01960 URS000080DFED_300852 34707295 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<......>>....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((..)))))))).)))))......(((......((((((((..((...(((((((.(((((....(.((((....)))).).....)))))....((((..((((....))))..))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((.(....).))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((.(((.....))).))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((.(((....))).)))....(((....)))....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the A2058-dimethylated Thermus thermophilus 70S ribosome in complex with iboxamycin, mRNA, deacylated A- and E-site tRNAs, and aminoacylated P-site tRNA at 2.60A resolution; 16S Ribosomal RNA 7rq9 1v 13 2.6 34707295 10665 aaaaauguucuaa ............. ............. Crystal structure of the A2058-dimethylated Thermus thermophilus 70S ribosome in complex with iboxamycin, mRNA, deacylated A- and E-site tRNAs, and aminoacylated P-site tRNA at 2.60A resolution; mRNA 7rq9 1w 72 2.6 RF00005 URS00005AA258_562 34707295 0030533 0006412 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcac <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.. (((((((..((((...[..)))).((((.........)))).....(((((..]....)))))))))))).. Crystal structure of the A2058-dimethylated Thermus thermophilus 70S ribosome in complex with iboxamycin, mRNA, deacylated A- and E-site tRNAs, and aminoacylated P-site tRNA at 2.60A resolution; A-site tRNA 7rq9 1x 76 2.6 RF00005 URS000041AF00_562 34707295 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaaccn <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the A2058-dimethylated Thermus thermophilus 70S ribosome in complex with iboxamycin, mRNA, deacylated A- and E-site tRNAs, and aminoacylated P-site tRNA at 2.60A resolution; P-site tRNA 7rq9 1y 74 2.6 RF00005 URS00005AA258_562 34707295 0030533 0006412 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((......)))).((((.........)))).....(((((.......)))))))))))).... Crystal structure of the A2058-dimethylated Thermus thermophilus 70S ribosome in complex with iboxamycin, mRNA, deacylated A- and E-site tRNAs, and aminoacylated P-site tRNA at 2.60A resolution; E-site tRNA 7rq9 2A 2800 2.6 RF02540,RF02541,RF00002 URS00001698E8_300852 34707295 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacganaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>....<<<<<.....<......>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<....<<<..........>>.>....>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<..>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<..>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<....<<..>>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((.....)))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...((((((((.....))))))))....{.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).))))....(((((((((.[.....)))))))))....}.(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....(())....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((....(...............)....)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((.().)))))))).))..........]]].)....))))))))))...)))))))(((((((..)))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((((.......)))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((.(((((((((.(......[..(((((...((.......(((((((....)))))))....))...........].)))))).))))))))).))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....))))))).............(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))....))) Crystal structure of the A2058-dimethylated Thermus thermophilus 70S ribosome in complex with iboxamycin, mRNA, deacylated A- and E-site tRNAs, and aminoacylated P-site tRNA at 2.60A resolution; 23S Ribosomal RNA 7rq9 2B 120 2.6 RF00001 URS000080DEE8_300852 34707295 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>>. .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the A2058-dimethylated Thermus thermophilus 70S ribosome in complex with iboxamycin, mRNA, deacylated A- and E-site tRNAs, and aminoacylated P-site tRNA at 2.60A resolution; 5S Ribosomal RNA 7rq9 2a 1503 2.6 RF00177,RF01959,RF01960 URS000080DFED_300852 34707295 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggau .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<...<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>...>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<......>>....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((.(....).)))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((((((....)))))))....(.(....).)....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.(.((....)).)).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}... Crystal structure of the A2058-dimethylated Thermus thermophilus 70S ribosome in complex with iboxamycin, mRNA, deacylated A- and E-site tRNAs, and aminoacylated P-site tRNA at 2.60A resolution; 16S Ribosomal RNA 7rq9 2v 13 2.6 34707295 10665 aaaaauguucuaa ............. ............. Crystal structure of the A2058-dimethylated Thermus thermophilus 70S ribosome in complex with iboxamycin, mRNA, deacylated A- and E-site tRNAs, and aminoacylated P-site tRNA at 2.60A resolution; mRNA 7rq9 2w 70 2.6 RF00005 URS00005AA258_562 34707295 0030533 0006412 562 cccgganagcucagggagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcac <<<<<<..<<<<.....>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>... ((((((..((((...[.)))).((((.........)))).....(((((..]....)))))))))))... Crystal structure of the A2058-dimethylated Thermus thermophilus 70S ribosome in complex with iboxamycin, mRNA, deacylated A- and E-site tRNAs, and aminoacylated P-site tRNA at 2.60A resolution; A-site tRNA 7rq9 2x 76 2.6 RF00005 URS000041AF00_562 34707295 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaaccn <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the A2058-dimethylated Thermus thermophilus 70S ribosome in complex with iboxamycin, mRNA, deacylated A- and E-site tRNAs, and aminoacylated P-site tRNA at 2.60A resolution; P-site tRNA 7rq9 2y 73 2.6 RF00005 URS00005AA258_562 34707295 0030533 0006412 562 gcccgganagcucagggagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<.....>>>>.<<<<<<<...>>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[.)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of the A2058-dimethylated Thermus thermophilus 70S ribosome in complex with iboxamycin, mRNA, deacylated A- and E-site tRNAs, and aminoacylated P-site tRNA at 2.60A resolution; E-site tRNA 7rqa 1A 2872 2.4 RF02540,RF02541,RF00002 URS00001698E8_300852 35165455 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<.<.<<<<<<......>>>>.>>>..>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<.......<<<<<<<......>>>>>>>....>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((...((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....((((((((..[......))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...((((((((.(.((((((......)))).)))..))))))))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((.(((((.((((((.(.........(((((..((.......(((((.((....)).)))))....))............)))))).)))))).))))).)))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..((((.))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, A-site aminoacyl-tRNA analog ACC-PMN, and P-site MTI-tripeptidyl-tRNA analog ACCA-ITM at 2.40A resolution; 23S Ribosomal RNA 7rqa 1B 120 2.4 RF00001 URS000080DEE8_300852 35165455 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>. .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, A-site aminoacyl-tRNA analog ACC-PMN, and P-site MTI-tripeptidyl-tRNA analog ACCA-ITM at 2.40A resolution; 5S Ribosomal RNA 7rqa 1a 1500 2.4 RF00177,RF01959,RF01960 URS000080DFED_300852 35165455 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>.................>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((..)))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((...(((.(((....))).))).(.((.(....).)))..)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, A-site aminoacyl-tRNA analog ACC-PMN, and P-site MTI-tripeptidyl-tRNA analog ACCA-ITM at 2.40A resolution; 16S Ribosomal RNA 7rqa 2A 2867 2.4 RF02540,RF02541,RF00002 URS00001698E8_300852 35165455 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..................>>>......................>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<..>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<.......<<<<<<......>>>>>>....>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((()))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((...((.(((......)))..))...)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((.(........((((.((....((.......)).....)).........(........)...))))....).)))))))).))..........]]].)....))))))))))...)))))))(((((((())))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((.((.((((((.(.........(((((..(((.......((((.(......).))))....)))............)))))).)))))).)).))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.((.))......(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, A-site aminoacyl-tRNA analog ACC-PMN, and P-site MTI-tripeptidyl-tRNA analog ACCA-ITM at 2.40A resolution; 23S Ribosomal RNA 7rqa 2B 120 2.4 RF00001 URS000080DEE8_300852 35165455 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, A-site aminoacyl-tRNA analog ACC-PMN, and P-site MTI-tripeptidyl-tRNA analog ACCA-ITM at 2.40A resolution; 5S Ribosomal RNA 7rqa 2a 1504 2.4 RF00177,RF01959,RF01960 URS000080DFED_300852 35165455 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>.....<......>....>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((((((....))))))).(...((....))...).)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, A-site aminoacyl-tRNA analog ACC-PMN, and P-site MTI-tripeptidyl-tRNA analog ACCA-ITM at 2.40A resolution; 16S Ribosomal RNA 7rqb 1A 2872 2.45 RF02540,RF02541,RF00002 URS00001698E8_300852 35165455 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<...<<<.......>>>...>>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((..(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...((((((((.(.((((((......)))).)))..))))))))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........(((((..(((......((((((((....))))))))...)))............)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..((((.))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, A-site aminoacyl-tRNA analog ACC-PMN, and P-site MAI-tripeptidyl-tRNA analog ACCA-IAM at 2.45A resolution; 23S Ribosomal RNA 7rqb 1B 120 2.45 RF00001 URS000080DEE8_300852 35165455 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>. .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, A-site aminoacyl-tRNA analog ACC-PMN, and P-site MAI-tripeptidyl-tRNA analog ACCA-IAM at 2.45A resolution; 5S Ribosomal RNA 7rqb 1a 1500 2.45 RF00177,RF01959,RF01960 URS000080DFED_300852 35165455 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<.<......>.>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((..)))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((...(((((((....)))))))...((((....))))...)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, A-site aminoacyl-tRNA analog ACC-PMN, and P-site MAI-tripeptidyl-tRNA analog ACCA-IAM at 2.45A resolution; 16S Ribosomal RNA 7rqb 2A 2867 2.45 RF02540,RF02541,RF00002 URS00001698E8_300852 35165455 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu .<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..................>>>......................>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<..>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<.......<<<<<<......>>>>>>....>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>. (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((...))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((..))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((...((((((......)))).))...)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((.(.........(((.((...(((.......)))....)).........(........)...))).....).)))))))).))..........]]].)....))))))))))...)))))))(((((((())))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((.((((((.(.........(((((..(((........(((.((....)).))).....)))............)))))).)))))).)))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))((((.))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, A-site aminoacyl-tRNA analog ACC-PMN, and P-site MAI-tripeptidyl-tRNA analog ACCA-IAM at 2.45A resolution; 23S Ribosomal RNA 7rqb 2B 120 2.45 RF00001 URS000080DEE8_300852 35165455 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> (((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).))))))))))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, A-site aminoacyl-tRNA analog ACC-PMN, and P-site MAI-tripeptidyl-tRNA analog ACCA-IAM at 2.45A resolution; 5S Ribosomal RNA 7rqb 2a 1504 2.45 RF00177,RF01959,RF01960 URS000080DFED_300852 35165455 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>.....<......>....>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((...(((((((....))))))).....((....)).....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, A-site aminoacyl-tRNA analog ACC-PMN, and P-site MAI-tripeptidyl-tRNA analog ACCA-IAM at 2.45A resolution; 16S Ribosomal RNA 7rqc 1A 2872 2.5 RF02540,RF02541,RF00002 URS00001698E8_300852 35165455 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>....<<<<<.....<<....>>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<...<<<.......>>>...>>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<.......<<<<<<<<....>>>>>>>>....>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((...((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....((((((((..[......))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...((((((((.(.((((((......)))).)))..))))))))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((.((((((.(......[..(((((..(((......((((((((....))))))))...)))..........].)))))).)))))).)))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..((((.))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, A-site aminoacyl-tRNA analog ACC-PMN, and P-site MFI-tripeptidyl-tRNA analog ACCA-IFM at 2.50A resolution; 23S Ribosomal RNA 7rqc 1B 120 2.5 RF00001 URS000080DEE8_300852 35165455 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>. .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, A-site aminoacyl-tRNA analog ACC-PMN, and P-site MFI-tripeptidyl-tRNA analog ACCA-IFM at 2.50A resolution; 5S Ribosomal RNA 7rqc 1a 1500 2.5 RF00177,RF01959,RF01960 URS000080DFED_300852 35165455 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<.<......>.>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((..)))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((...(((((((....)))))))...((((....))))...)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, A-site aminoacyl-tRNA analog ACC-PMN, and P-site MFI-tripeptidyl-tRNA analog ACCA-IFM at 2.50A resolution; 16S Ribosomal RNA 7rqc 2A 2867 2.5 RF02540,RF02541,RF00002 URS00001698E8_300852 35165455 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>....<<<<<.....<<....>>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<.<.<<<<<<......>>>>.>>>..>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<....<.........>.....>>......................>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<..>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<.......<<<<<<......>>>>>>....>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((()))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...((((((((...((.(((......)))..))...))))))))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((........((((.((...(((.......)))....))......................))))....)))))))))).))..........]]].)....))))))))))...)))))))(((((((())))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((.((.((((((.(......[..(((((..(((.......((((.((....)).))))....)))..........].)))))).)))))).)).))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(..(.).......(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, A-site aminoacyl-tRNA analog ACC-PMN, and P-site MFI-tripeptidyl-tRNA analog ACCA-IFM at 2.50A resolution; 23S Ribosomal RNA 7rqc 2B 120 2.5 RF00001 URS000080DEE8_300852 35165455 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, A-site aminoacyl-tRNA analog ACC-PMN, and P-site MFI-tripeptidyl-tRNA analog ACCA-IFM at 2.50A resolution; 5S Ribosomal RNA 7rqc 2a 1504 2.5 RF00177,RF01959,RF01960 URS000080DFED_300852 35165455 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<....<<<......>>>.......>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<.<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>.....<......>....>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>..>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((.(..((((((((((......((........))..........(((((((..(...(((((((...(((((((....)))))))....(((....)))....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..).))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, A-site aminoacyl-tRNA analog ACC-PMN, and P-site MFI-tripeptidyl-tRNA analog ACCA-IFM at 2.50A resolution; 16S Ribosomal RNA 7rqd 1A 2872 2.5 RF02540,RF02541,RF00002 URS00001698E8_300852 35165455 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>....<<<<<.....<<....>>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<....<<.......>>....>>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<.......<<<<<<<<<..>>>>>>>>>....>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((..(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....((((((((..[......))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...((((((((.(.((((((......)))).)))..))))))))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((..))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.([........(((((..(((......((((((((...]))))))))...)))............)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..((((.))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, A-site deacylated tRNA analog CACCA, P-site MTI-tripeptidyl-tRNA analog ACCA-ITM, and chloramphenicol at 2.50A resolution; 23S Ribosomal RNA 7rqd 1B 120 2.5 RF00001 URS000080DEE8_300852 35165455 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>. .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, A-site deacylated tRNA analog CACCA, P-site MTI-tripeptidyl-tRNA analog ACCA-ITM, and chloramphenicol at 2.50A resolution; 5S Ribosomal RNA 7rqd 1a 1500 2.5 RF00177,RF01959,RF01960 URS000080DFED_300852 35165455 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<.<......>.>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((())))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((...(((((((....)))))))...((((....))))...)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, A-site deacylated tRNA analog CACCA, P-site MTI-tripeptidyl-tRNA analog ACCA-ITM, and chloramphenicol at 2.50A resolution; 16S Ribosomal RNA 7rqd 2A 2867 2.5 RF02540,RF02541,RF00002 URS00001698E8_300852 35165455 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<....<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.....>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<....................>>......................>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<..>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<.......<<<<<<......>>>>>>....>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((...))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....((((((((..[......))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((..))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((.(.((.(((......)))..)))..)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((.(.........(((.(....(((.......))).....).........(........)...))).....).)))))))).))..........]]].)....))))))))))...)))))))(((((((..)))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(.(((.........))).)........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........(((((..(((........(((.((....)).))).....)))............)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))((((.))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, A-site deacylated tRNA analog CACCA, P-site MTI-tripeptidyl-tRNA analog ACCA-ITM, and chloramphenicol at 2.50A resolution; 23S Ribosomal RNA 7rqd 2B 120 2.5 RF00001 URS000080DEE8_300852 35165455 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> (((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).))))))))))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, A-site deacylated tRNA analog CACCA, P-site MTI-tripeptidyl-tRNA analog ACCA-ITM, and chloramphenicol at 2.50A resolution; 5S Ribosomal RNA 7rqd 2a 1504 2.5 RF00177,RF01959,RF01960 URS000080DFED_300852 35165455 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<....<<<......>>>.......>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>.....<......>....>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((((((....))))))).....((....)).....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, A-site deacylated tRNA analog CACCA, P-site MTI-tripeptidyl-tRNA analog ACCA-ITM, and chloramphenicol at 2.50A resolution; 16S Ribosomal RNA 7rqe 1A 2872 2.4 RF02540,RF02541,RF00002 URS00001698E8_300852 35165455 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<...<<<.......>>>...>>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<<..>>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((..(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...((((((((.(.((((((......)))).)))..))))))))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........(((((..(((......((((((((....))))))))...)))............)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..((((.))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, A-site deacylated tRNA analog CACCA, P-site MAI-tripeptidyl-tRNA analog ACCA-IAM, and chloramphenicol at 2.40A resolution; 23S Ribosomal RNA 7rqe 1B 120 2.4 RF00001 URS000080DEE8_300852 35165455 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>. .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, A-site deacylated tRNA analog CACCA, P-site MAI-tripeptidyl-tRNA analog ACCA-IAM, and chloramphenicol at 2.40A resolution; 5S Ribosomal RNA 7rqe 1a 1500 2.4 RF00177,RF01959,RF01960 URS000080DFED_300852 35165455 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<.<......>.>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((..)))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))).)...))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((...(((((((....)))))))...((((....))))...)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, A-site deacylated tRNA analog CACCA, P-site MAI-tripeptidyl-tRNA analog ACCA-IAM, and chloramphenicol at 2.40A resolution; 16S Ribosomal RNA 7rqe 2A 2867 2.4 RF02540,RF02541,RF00002 URS00001698E8_300852 35165455 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu 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.((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((..))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((.(.((.(((......)))..)))..)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......(((((.((....((.......)).....))......................)))))...)))))))))).))..........]]].)....))))))))))...)))))))(((((((())))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..((((..((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....).))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((.((((((.(.........(((((..(((........(((.((....)).))).....)))............)))))).)))))).)))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))((((.))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...))). Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, A-site deacylated tRNA analog CACCA, P-site MAI-tripeptidyl-tRNA analog ACCA-IAM, and chloramphenicol at 2.40A resolution; 23S Ribosomal RNA 7rqe 2B 120 2.4 RF00001 URS000080DEE8_300852 35165455 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> (((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).))))))))))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, A-site deacylated tRNA analog CACCA, P-site MAI-tripeptidyl-tRNA analog ACCA-IAM, and chloramphenicol at 2.40A resolution; 5S Ribosomal RNA 7rqe 2a 1504 2.4 RF00177,RF01959,RF01960 URS000080DFED_300852 35165455 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>.....<......>....>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((.(.((((((((((......((((((.....))))))....))))))))..))).)))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((((((....))))))).....((....)).....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, A-site deacylated tRNA analog CACCA, P-site MAI-tripeptidyl-tRNA analog ACCA-IAM, and chloramphenicol at 2.40A resolution; 16S Ribosomal RNA 7rr5 C1 3221 3.23 RF02540,RF02543 URS000061F377_4932 34706231 0003735 0005840 4932 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaugguguuuuguauuucacgccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauagaggguguagaauaagugggagcuucggcgccagugaaauaccacuaccuuuauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<.<<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<<......................<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<....<<.<<<<<<<.....<<<....<<<..<.<<<<...<<<<<<.....>>>>>>.>>>>.>..>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>..>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<.<.....>..>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<.<<<<<<<<<<<....>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.....<<.....<<<<....>>>>.....>>..>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<<<<<<<<<..........<<.<<......................>>.>>.>>>>>>>.>>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>..>>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<...<<<<<<<<<<<}}}.>>>>>..>>>>>>..>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<.<..<<<<<......>>>>>..>>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((......................(((((((((((((((((((((((.......(((((((......((((.(....).)))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((....((.(((((((.....(((....(((..(.((((....(((((.....)))))..)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...((((((...((.....)).))))))....[[(((.((...((....(((....)))........((((..(.....)...))))....))....))...(((((........)))))]]((((.((((.(((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....)))...)))))))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((....)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((((((((.(.(.......[..((..(..(......)..........].)..)).)..)))).))))))))))....((((.....((((..((((........))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Structure of ribosomal complex bound with Rbg1/Tma46; 25S rRNA 7rr5 C4 121 3.23 RF00001 URS000055688D_4932 34706231 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<<............>>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Structure of ribosomal complex bound with Rbg1/Tma46; 5S rRNA 7rr5 C3 158 3.23 RF00002 URS00001BF64E_4932 34706231 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<(.....>>............).>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Structure of ribosomal complex bound with Rbg1/Tma46; 5.8S rRNA 7rr5 C2 1771 3.23 RF01960,RF01959,RF00177 URS00005F2C2D_4932 34706231 0003735 0005840 4932 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugagcuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauu ...<<<<<.{.((((>>>>><<<<.<<<<<<...<.<...<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<..<<..<<....<<<..................<<....<<.<<.......>>.>>.....>>.........<<<<<..<<....>>..>>>>><.<.<<<<<<......(((.{((.<<......>>..............>>>>>>.>...>...<<<<.<<<<.....>>>>>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>..>>>..>....>.>.....<<<<<<<<<<<<<....>>>>>>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>>.........<<<[[.....<.<<...<<<.<<....<<<<<<.<<<<..............>>>>.>>>>>>....<<<<<<....................>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........<<<..<<<<<<<<.....)).}))).>>>>>>>>.>>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..]]>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..)))).}<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>......<....<<<<<<..........>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<.<<<<..............>>>>.>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>........ ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((.....(..........)....)){))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[[.[[[.(((....))).....(......).)))))).)...).(.((((...(((..).))..)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(((((((((.(((....))).)))))).)))......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((................))).)))))).....(((((....................)))))....(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(......((.(((.....]].]]]].))).)).....).....))...(((..((.((...((((..((..((((((.(...((........))......).))))))..)).......((....))...))))..)).))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].].((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((.(..(((.((.((....))...(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..))))).)..))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).)...(.(..((.(..((((.((..(.((((((((.(((..(.((..(...((((((..((((..............))))..))))))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>....... Structure of ribosomal complex bound with Rbg1/Tma46; 18S rRNA 7rr5 A 76 3.23 RF00005 URS0002311986_4932 34706231 0030533 0006412 4932 gggucguuagcucaguugguagagcaguugacuuuuuaucaauuggucgcagguucgaauccugcacgacccacca <<<<<<<..<<<<........>>>><<<<<<.......>>>>>>....<<<<<.......>>>>>>>>>>>>.... ((((((...((((........))))(.((((.......)))).).....((((.......))))..)))))).... Structure of ribosomal complex bound with Rbg1/Tma46; A-tRNA 7rr5 P 76 3.23 RF00005 URS00023119BF_4932 34706231 0030533 0006412 4932 uuccucguggcccaauggucacggcgucuggcuucgaaccagaagauuccagguucaaguccuggcggggaagcca <<<<<<<..<<<..........>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... ((((.((..(((.....[....))).(((((.......))))).....(((((..]....))))))).)))).... Structure of ribosomal complex bound with Rbg1/Tma46; P-tRNA 7rr5 m 16 3.23 34706231 4932 uggauggaacgaaaaa ................ ................ Structure of ribosomal complex bound with Rbg1/Tma46; mRNA 7ryf A 2685 2.65 RF02540,RF02541 URS000231197A_480119 35100868 0003735 0005840 480119 gucaaguaauuaagugcaugugguggaugccuuggcagucagaggcgaugaaagacgugauagccugcgaaaagcuccggggaggcggcaaauauccuuugauccggagaugucugaaugggggaacccaccuacuuuaagguagguauugcaacaugaauacauaguguugcaaggcgaacgaggggaagugaaacaucucaguacccuuaggaaaagaaaucaauugagauucccucaguagcggcgagcgaacggggaucagcccauuaaguuauguguguuuuaguggaacgcucugggaagugcgaacguagagggugauauucccguacacgaaagggcacacauaaugaugacgaguagggcgaggcacgugaaaccuugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccugugaggggagugaaauagauccugaaaccgcaugcauacaagcagugggagcaccuucguggugugacugcguaccuuuuguauaaugggucagcgacuuauauucaguagcgagguuaaccguauaggggagccguagagaaaucgagucuuaauagggcguuuaguugcuggguauagacccgaaaccaggcgaucuauccaugagcagguugaagguuggguaacacuaacuggaggaccgaacccacugucguugaaaagccaggggaugacuuguggauaggggugaaaggcuaaucaagccuggugauagcugguucuccccgaaagcuauuuagguagcgccucggacgaauaccauaggggguagagcacuguuucggcaccgaugcaaacuccgaauaccuaugaguacuauccgggagacagacugcgggugcuaacguccguagucaagaggaaaacaauccagaccgccagcuaaggccccaaaaucauaguuaagugggaaacgaugugggaaggcauagacagcuauagucgagucggccugcgcggaagauguaacggggcuaaaacuaugugccgaagcugcggauguauacuuuguauacgugguaggggagcguucuguaagccgaugaagguguguugagaagcaugcuggagguaucagaagugcgaaugcugacgugaguaacgacaaaacgggugaaaaacccguucgccgaaagaccaaggguuccaguccaacguuaaucggggcugggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaaaugguuaauauuccauuacuucuguguaaugcgaugagaggacggagaaggcuaaaucagccuggcguugguuguccaggugaaaggauguaggcaaugcugagaucugauagcaagcuguacuugugcagcgaagugguugaugccaugcuuccaggaaaagucucuaagcuucaguuacacaggaaucguacccgaaaccgacacagguggucaggucgaguagaccaaggcgcuugagagaacucugcugaaggaacuaggcaaaaugguaccguaacuucgggagaagguacgcuguuguuggugauggaacucgcuuccugagcugacgacagccgcagaaaccaggccgcugcaacuguuuauuaaaaacauagcacucugcaaacacgaaaguggacguauagggugugaugccugcccggugcuggaagguuaauugaugggguuagcguaagcgaagcucuugaucgaagccccaguaaacggcgccuaagguagcgaaanuccuugucggguaaguuccgaccugcacgaauggcauaaugauggcggcgcugucuccagcagaggcucagugaaaucgaaaucgcugugnagaugcaguguacccgcggcuagacggaaagaccccgunaaccuuuacugcagcuugacacugaacuuugauugagguucuaacucugucccgugauccgggacgaggaccgugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggaguacgaaggugcgcucagcguggucggaaaucacgcguagaguauaaaggcaaaagcgcgcuuaacugcgagacccacaagucgagcagguacgaaaguaggucuuagugauccggugguucuguauggaagggccaucgcucaacggauaaaagguacucugnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgnugucggcucaucucauccuggggcugaagcaggucccaaggguauggcnguucgccauuuaaagagguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucuaccgugggcgcuggaaauuugagaggaucugcuccuaguacgagaggaccagaguggacgaaccucugguguaccgguugugacgccagucgcaucgccggguagcuauguucggaagggauaaccgcugaaagcaucuaagcgggaagccuaccucaagauaagauuucccuaggacuuuauguccucuaaagagccguucgagacuaggacguugauagguuggauguggaagcauagugauaugugaagcugaccaauacuaauugcucgugaggcuugacu <<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<.)))......>>.....>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<......<<<<<<<<<<<<<..<<<...<<<.<......>.>>>((......<<<.....))>>>...>>>....>>>>>>>>>>>>>...........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..>>>......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<.....>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<.<........>.>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<....<<<<<<<<<.....<<<...<<<.<<<<..>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<.<<<<<<..<<.........<<..>>.....>>..>>>>>>>>...........)))......>>>>>>.>>>...>>>>>>><<<<<<<<...>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<...((((...>>>>>>....<<<<...<<<<.>>>>...>>>>........<<<<<......>>>>>....>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<....<<..>>.....>>>>><<<<<<<<<<<<...<<<<.....>>>>...>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<..<......>...>>>>>........>>>>>>>>..>>>>>..........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<.<<<<.[[......<<<<.[[<<<<..<<<<..<<<.<<<<<.<<<<<<<<..>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>...>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<.................>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))))>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<<<<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>...>>>>..>..>>>>>>>. ((((((([.....((((((((((.....(((..(((((((((((((......((((((.[[.[[[.))).....((((((...((.]]]..]]..))......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.....((.(((((((((.(.(((...(((.(......).)))[[(...).(((.....]])))...)))...).))))))))).))......)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((.....)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((........)))))...)[)))...(((.(((.(........).))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).(((((((...((((((((((.....(((...(((.((((..)))).)))..)).).....)))))).))).).)))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{...(()).....)))..))))).))...........]]].)....))))))))))...)))))))((((((((...))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((...(((...(((....)))...)))...)))..(((((........)))))]](((((((((.(((...((((....((((..(((..((((((((((((...{{{.).))))))....((((...((((.))))..[)))).....(..((((((....))))))...))))))...)))...))))(..).....))))...))....).))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((.(((...(((((..)]))))...))).))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..(......)...)))))........))))))))..)))))()........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..(((((((..(((.((......(((..((((((..(((((.(((.(((((.((((((((()))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..)).)))......((((..(.((((((.................))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(.(((((....))).)).)....))..))).)))))))[...(((((((...((((..((((((......(....).....)))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..)])))))(....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))..).)))))))). A. baumannii Ribosome-TP-6076 complex: P-site tRNA 70S; 23S ribosomal RNA 7ryf B 115 2.65 RF00001 URS00002D8B10_480119 35100868 0003735 0005840 480119 gcuggcgaccauagcaagagugaaccaccugaucccuucccgaacucagaagugaaaccucuuagcgcugaugguagugugggauuacccaugugagaguaagucaucgccagcu <<<<<<<<.....<<<<<<<.....<<<<<<...............>>>..>>>....>>>>>.>><<<.......<<<<<<<....>>>>>>>.......>>>..>>>>>>>>. (((((((......(((((((.....(((.((....(.....)....))...)))....))))).))(((.......(((((((....))))))).......)))...))))))). A. baumannii Ribosome-TP-6076 complex: P-site tRNA 70S; 5S ribosomal RNA 7ryf a 1528 2.65 RF00177,RF01959,RF01960 URS00023119FB_480119 35100868 0003735 0005840 480119 uaacugaagaguuugaucauggcucagauugaacgcuggcggcaggcuuaacacaugcaagucgagcgggggaagguagcuugcuaccggaccuagcggcggacgggugaguaaugcuuaggaaucugccuauuagugggggacaacaucucgaaagggaugcuaauaccgcauacguccuacgggagaaagcaggggaucuucggaccuugcgcuaauagaugagccuaagucggauuagcuaguuggugggguaaaggccuaccaaggcgacgaucuguagcgggucugagaggaugauccgccacacugggacugagacacggcccagacuccuacgggaggcagcaguggggaauauuggacaauggggggaacccugauccagccaugccgcgugugugaagaaggccuuaugguuguaaagcacuuuaagcgaggaggaggcuacucuaguuaauaccuagggauaguggacguuacucgcagaauaagcaccggcuaacucugugccagcagccncgguaauacagagggugcgagcguuaaucggauuuacugggcguaaagcgugcguaggcggcuuauuaagucggaugugaaauccccgagcuuaacuugggaauugcauucgauacuggugagcuagaguaugggagaggaugguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgauggcgaaggcagccaucuggccuaauacugacgcugagguacgaaagcauggggagcaaacaggauuagauacccugguaguccaugccguaaacgaugucuacuagccguuggggccuuugaggcuuuaguggcgcagcuaacgcgauaaguagaccgccuggggaguacggucgcaagacuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggccuugacauacuagaaacuuuucagagauggauuggugccuucgggaaccuagauacaggugcugcauggcugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuuuuccuuacuugccagcauuucggaugggaacuuuaaggauacugccagugacaaacuggaggaaggcggggacgacgucaagucaucaugncccuuacggccagggcuacacacgugcuacaauggucgguacaaaggguugcuacacagcgaugugaugcuaaucucaaaaagccgaucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucgcggaucagaaugccgcggugaauacguucccgggccuuguacacaccgnccgucacaccaugggaguuuguugcaccagaaguagcuagccuaacugcaaagagggcgguuaccacgguguggccgaugacuggggugaagucgnaacaagguagccguaggggnnccugcggcuggauc ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<<...<<<<<....>>>>>...>>>.>>>>>......<<.......<<<<<<<..<<...<<<<<<<<<.<<.....<<<<<<....>>>>>>......>>.>.....<<<....>>>....<<<<<<..........>>>>>>>>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>.....<<<<<......<<<<.<<<<.........>>>>..>>>>........>>>>>.......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<.<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>..>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<<...>>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<.......<<<<<...<..<<<<....>>>>..>...<<....>>...>>>>.>..<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<<..<<<.....>>>>>.....>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<.<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>.>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((...(((((....)))))...))).)))))......(((......(((((((..((...(((((((((.((.....((((((....))))))......)).).....(((....)))....(((.((..(......))).)))))))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(...(((...(..(((..(((...........)).)..)))...)....)))......)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((((((...)))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((...(..(.((....)).)..)...((....))...)))).))).((.(((...((((((.(....((((..(((....)))...(((......))).....)))).....((((.((((((....((..(((.....))))).....))))))..(..((((.......)))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((.((.(((((....(((.(..((((..((....)).)))).).)))...))))).)).)))..))).))))..).))...)..)..(((((((((....)))))))))}.... A. baumannii Ribosome-TP-6076 complex: P-site tRNA 70S; 16S Ribosomal RNA 7ryf v 77 2.65 RF00005 URS00002D670D_480119 35100868 0030533 0006412 480119 ggcuaugnagcucaguuggnuagagcaccgcacucauaaugcgggggucacaagnucaagucucgucauagccacca <<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<.<<.......>>.>>>>>>>>>.... (((((((..((((.........)))).(((((.......))))).....((.((.......)).))))))))).... A. baumannii Ribosome-TP-6076 complex: P-site tRNA 70S; tRNA-met 7ryg A 2685 2.38 RF02540,RF02541 URS000231197A_480119 35100868 0003735 0005840 480119 gucaaguaauuaagugcaugugguggaugccuuggcagucagaggcgaugaaagacgugauagccugcgaaaagcuccggggaggcggcaaauauccuuugauccggagaugucugaaugggggaacccaccuacuuuaagguagguauugcaacaugaauacauaguguugcaaggcgaacgaggggaagugaaacaucucaguacccuuaggaaaagaaaucaauugagauucccucaguagcggcgagcgaacggggaucagcccauuaaguuauguguguuuuaguggaacgcucugggaagugcgaacguagagggugauauucccguacacgaaagggcacacauaaugaugacgaguagggcgaggcacgugaaaccuugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccugugaggggagugaaauagauccugaaaccgcaugcauacaagcagugggagcaccuucguggugugacugcguaccuuuuguauaaugggucagcgacuuauauucaguagcgagguuaaccguauaggggagccguagagaaaucgagucuuaauagggcguuuaguugcuggguauagacccgaaaccaggcgaucuauccaugagcagguugaagguuggguaacacuaacuggaggaccgaacccacugucguugaaaagccaggggaugacuuguggauaggggugaaaggcuaaucaagccuggugauagcugguucuccccgaaagcuauuuagguagcgccucggacgaauaccauaggggguagagcacuguuucggcaccgaugcaaacuccgaauaccuaugaguacuauccgggagacagacugcgggugcuaacguccguagucaagaggaaaacaauccagaccgccagcuaaggccccaaaaucauaguuaagugggaaacgaugugggaaggcauagacagcuauagucgagucggccugcgcggaagauguaacggggcuaaaacuaugugccgaagcugcggauguauacuuuguauacgugguaggggagcguucuguaagccgaugaagguguguugagaagcaugcuggagguaucagaagugcgaaugcugacgugaguaacgacaaaacgggugaaaaacccguucgccgaaagaccaaggguuccaguccaacguuaaucggggcugggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaaaugguuaauauuccauuacuucuguguaaugcgaugagaggacggagaaggcuaaaucagccuggcguugguuguccaggugaaaggauguaggcaaugcugagaucugauagcaagcuguacuugugcagcgaagugguugaugccaugcuuccaggaaaagucucuaagcuucaguuacacaggaaucguacccgaaaccgacacagguggucaggucgaguagaccaaggcgcuugagagaacucugcugaaggaacuaggcaaaaugguaccguaacuucgggagaagguacgcuguuguuggugauggaacucgcuuccugagcugacgacagccgcagaaaccaggccgcugcaacuguuuauuaaaaacauagcacucugcaaacacgaaaguggacguauagggugugaugccugcccggugcuggaagguuaauugaugggguuagcguaagcgaagcucuugaucgaagccccaguaaacggcgccuaagguagcgaaanuccuugucggguaaguuccgaccugcacgaauggcauaaugauggcggcgcugucuccagcagaggcucagugaaaucgaaaucgcugugnagaugcaguguacccgcggcuagacggaaagaccccgunaaccuuuacugcagcuugacacugaacuuugauugagguucuaacucugucccgugauccgggacgaggaccgugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggaguacgaaggugcgcucagcguggucggaaaucacgcguagaguauaaaggcaaaagcgcgcuuaacugcgagacccacaagucgagcagguacgaaaguaggucuuagugauccggugguucuguauggaagggccaucgcucaacggauaaaagguacucugnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgnugucggcucaucucauccuggggcugaagcaggucccaaggguauggcnguucgccauuuaaagagguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucuaccgugggcgcuggaaauuugagaggaucugcuccuaguacgagaggaccagaguggacgaaccucugguguaccgguugugacgccagucgcaucgccggguagcuauguucggaagggauaaccgcugaaagcaucuaagcgggaagccuaccucaagauaagauuucccuaggacuuuauguccucuaaagagccguucgagacuaggacguugauagguuggauguggaagcauagugauaugugaagcugaccaauacuaauugcucgugaggcuugacu <<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<.)))......>>.....>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<......<<<<<<<<<<<<<<.<<<...<<<.<......>.>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>...........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..>>>......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<<.....>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<.<........>.>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<....<<<<<<<<<.....<<<...<<<.<<<<..>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<.<<<<<<..<<.........<<..>>.....>>..>>>>>>>>...........)))......>>>>>>.>>>...>>>>>>><<<<<<<.....>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<...((((...>>>>>>....<<<<...<<<<.>>>>...>>>>........<<<<<......>>>>>....>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<<<<<<<...<<<<.....>>>>...>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<..<<....>>...>>>>>........>>>>>>>>..>>>>>..........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<.<<<<.[[......<<<<.[[<<<<..<<<<..<<<.<<<<<.<<<<<<<<..>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>...>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<..<<<<<<<.......>>>>>>.>...<<.[.(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<.................>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))))>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<<<<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>...>>>>..>..>>>>>>>. ((((((([.....((((((((((.....(((..(((((((((((((......((((((..[.[[[.))).....((((((...((.]]]..]...))......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((..(..((.(((((((((((.(((...(((.(......).)))[[(...).(((.....]])))...)))...))))))))))).))...)..)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((.....)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((........)))))...)[)))...(((.(((.(........).))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).(((((((...((((((((((.....(((...(((.((((..)))).)))..)).).....)))))).))).).)))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.........(()).....)))..))))).))...........]]].)....))))))))))...)))))))((((((((...))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((....(((....((((..(((..((((((((((((...{{{.).))))))....((((...((((.))))..[)))).....(..((((((....))))))...))))))...)))...))))(..).....)))....))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((...((((....]))))...))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))()........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..(((((((..(((.((......(((..((((((..(((((.(((.(((((.((((((.(()).))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.((((.(........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..)).)))......((((..(.((((((...((...[...))...))))))...).)).).)......(.((.((((((..(((((((((].....))))))..))).(((((.....))))).....)))))..)...))..).....(.(((((....))).)).)....))..))).)))))))[...(((((((...((((..((((((......(....).....)))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.((((((..)])))))(....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))..).)))))))). A. baumannii Ribosome-TP-6076 complex: E-site tRNA 70S; 23S ribosomal RNA 7ryg B 115 2.38 RF00001 URS00002D8B10_480119 35100868 0003735 0005840 480119 gcuggcgaccauagcaagagugaaccaccugaucccuucccgaacucagaagugaaaccucuuagcgcugaugguagugugggauuacccaugugagaguaagucaucgccagcu <<<<<<<<.....<<<<<<<.....<<<<<<...............>>>..>>>....>>>>>.>><<<.......<<<<<<<....>>>>>>>.......>>>..>>>>>>>>. ((((((((.....(((((((.....(((.(((...(.....)...)))...)))....))))).))(((.......(((((((....))))))).......)))..)))))))). A. baumannii Ribosome-TP-6076 complex: E-site tRNA 70S; 5S ribosomal RNA 7ryg a 1528 2.38 RF00177,RF01959,RF01960 URS00023119FB_480119 35100868 0003735 0005840 480119 uaacugaagaguuugaucauggcucagauugaacgcuggcggcaggcuuaacacaugcaagucgagcgggggaagguagcuugcuaccggaccuagcggcggacgggugaguaaugcuuaggaaucugccuauuagugggggacaacaucucgaaagggaugcuaauaccgcauacguccuacgggagaaagcaggggaucuucggaccuugcgcuaauagaugagccuaagucggauuagcuaguuggugggguaaaggccuaccaaggcgacgaucuguagcgggucugagaggaugauccgccacacugggacugagacacggcccagacuccuacgggaggcagcaguggggaauauuggacaauggggggaacccugauccagccaugccgcgugugugaagaaggccuuaugguuguaaagcacuuuaagcgaggaggaggcuacucuaguuaauaccuagggauaguggacguuacucgcagaauaagcaccggcuaacucugugccagcagccncgguaauacagagggugcgagcguuaaucggauuuacugggcguaaagcgugcguaggcggcuuauuaagucggaugugaaauccccgagcuuaacuugggaauugcauucgauacuggugagcuagaguaugggagaggaugguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgauggcgaaggcagccaucuggccuaauacugacgcugagguacgaaagcauggggagcaaacaggauuagauacccugguaguccaugccguaaacgaugucuacuagccguuggggccuuugaggcuuuaguggcgcagcuaacgcgauaaguagaccgccuggggaguacggucgcaagacuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggccuugacauacuagaaacuuuucagagauggauuggugccuucgggaaccuagauacaggugcugcauggcugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuuuuccuuacuugccagcauuucggaugggaacuuuaaggauacugccagugacaaacuggaggaaggcggggacgacgucaagucaucaugncccuuacggccagggcuacacacgugcuacaauggucgguacaaaggguugcuacacagcgaugugaugcuaaucucaaaaagccgaucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucgcggaucagaaugccgcggugaauacguucccgggccuuguacacaccgnccgucacaccaugggaguuuguugcaccagaaguagcuagccuaacugcaaagagggcgguuaccacgguguggccgaugacuggggugaagucgnaacaagguagccguaggggnnccugcggcuggauc ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<<...<<<<<<..>>>>>>...>>>.>>>>>......<<.......<<<<<<<..<<...<<<<<<<<<.<<.....<<<<<<....>>>>>>......>>.>.....<<<....>>>....<<<<<<..........>>>>>>>>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<<<<<<<<<<.......>>>>>>.>>>>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<.<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>..>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<<...>>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<...<..<<<<....>>>>..>...<<....>>...>>>>.>>.<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<<..<<<.....>>>>>.....>>>>>>.....<<<<<.....>>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<.<<.<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>.>>.>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((...((((((..))))))...))).)))))......(((......(((((((..((...(((((((((.((.....((((((....))))))......)).).....(((....)))....(((.((..........)).)))))))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..(.((......((((....)))).....)).)...(.(.(((...(..((((((((((.......)))))).))))...)....))).)....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((.(((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))..))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((((((...)))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((...(..(.((....)).)..)...((....))...)))).))).((.(((...((((((.(....((((.((((....)))...(((......)))...).)))).....((((.((((((....((..(((.....))))).....))))))..(..((((.......)))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((....(((..((..(((.((.(((((.....((((..((((...(....)..)))).))))....))))).)).)))..))..))).....))...)..)..(((((((((....)))))))))}.... A. baumannii Ribosome-TP-6076 complex: E-site tRNA 70S; 16S Ribosomal RNA 7ryg v 77 2.38 RF00005 URS00002D670D_480119 35100868 0030533 0006412 480119 ggcuaugnagcucaguuggnuagagcaccgcacucauaaugcgggggucacaagnucaagucucgucauagccacca <<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<.<<.......>>.>>>>>>>>>.... (((((((..((((.........)))).(((((.......))))).....((.((.......)).))))))))).... A. baumannii Ribosome-TP-6076 complex: E-site tRNA 70S; tRNA-met 7ryh A 2685 2.43 RF02540,RF02541 URS000231197A_480119 35100868 0003735 0005840 480119 gucaaguaauuaagugcaugugguggaugccuuggcagucagaggcgaugaaagacgugauagccugcgaaaagcuccggggaggcggcaaauauccuuugauccggagaugucugaaugggggaacccaccuacuuuaagguagguauugcaacaugaauacauaguguugcaaggcgaacgaggggaagugaaacaucucaguacccuuaggaaaagaaaucaauugagauucccucaguagcggcgagcgaacggggaucagcccauuaaguuauguguguuuuaguggaacgcucugggaagugcgaacguagagggugauauucccguacacgaaagggcacacauaaugaugacgaguagggcgaggcacgugaaaccuugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccugugaggggagugaaauagauccugaaaccgcaugcauacaagcagugggagcaccuucguggugugacugcguaccuuuuguauaaugggucagcgacuuauauucaguagcgagguuaaccguauaggggagccguagagaaaucgagucuuaauagggcguuuaguugcuggguauagacccgaaaccaggcgaucuauccaugagcagguugaagguuggguaacacuaacuggaggaccgaacccacugucguugaaaagccaggggaugacuuguggauaggggugaaaggcuaaucaagccuggugauagcugguucuccccgaaagcuauuuagguagcgccucggacgaauaccauaggggguagagcacuguuucggcaccgaugcaaacuccgaauaccuaugaguacuauccgggagacagacugcgggugcuaacguccguagucaagaggaaaacaauccagaccgccagcuaaggccccaaaaucauaguuaagugggaaacgaugugggaaggcauagacagcuauagucgagucggccugcgcggaagauguaacggggcuaaaacuaugugccgaagcugcggauguauacuuuguauacgugguaggggagcguucuguaagccgaugaagguguguugagaagcaugcuggagguaucagaagugcgaaugcugacgugaguaacgacaaaacgggugaaaaacccguucgccgaaagaccaaggguuccaguccaacguuaaucggggcugggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaaaugguuaauauuccauuacuucuguguaaugcgaugagaggacggagaaggcuaaaucagccuggcguugguuguccaggugaaaggauguaggcaaugcugagaucugauagcaagcuguacuugugcagcgaagugguugaugccaugcuuccaggaaaagucucuaagcuucaguuacacaggaaucguacccgaaaccgacacagguggucaggucgaguagaccaaggcgcuugagagaacucugcugaaggaacuaggcaaaaugguaccguaacuucgggagaagguacgcuguuguuggugauggaacucgcuuccugagcugacgacagccgcagaaaccaggccgcugcaacuguuuauuaaaaacauagcacucugcaaacacgaaaguggacguauagggugugaugccugcccggugcuggaagguuaauugaugggguuagcguaagcgaagcucuugaucgaagccccaguaaacggcgccuaagguagcgaaanuccuugucggguaaguuccgaccugcacgaauggcauaaugauggcggcgcugucuccagcagaggcucagugaaaucgaaaucgcugugnagaugcaguguacccgcggcuagacggaaagaccccgunaaccuuuacugcagcuugacacugaacuuugauugagguucuaacucugucccgugauccgggacgaggaccgugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggaguacgaaggugcgcucagcguggucggaaaucacgcguagaguauaaaggcaaaagcgcgcuuaacugcgagacccacaagucgagcagguacgaaaguaggucuuagugauccggugguucuguauggaagggccaucgcucaacggauaaaagguacucugnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgnugucggcucaucucauccuggggcugaagcaggucccaaggguauggcnguucgccauuuaaagagguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucuaccgugggcgcuggaaauuugagaggaucugcuccuaguacgagaggaccagaguggacgaaccucugguguaccgguugugacgccagucgcaucgccggguagcuauguucggaagggauaaccgcugaaagcaucuaagcgggaagccuaccucaagauaagauuucccuaggacuuuauguccucuaaagagccguucgagacuaggacguugauagguuggauguggaagcauagugauaugugaagcugaccaauacuaauugcucgugaggcuugacu <<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<.)))......>>.....>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<......<<<<<<<<<<<<<..<<<...<<<.<......>.>>>((......<<<.....))>>>...>>>....>>>>>>>>>>>>>...........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..>>>......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<.....>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<.<........>.>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<....<<<<<<<<<.....<<<...<<<.<<<<..>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<.<<<<<<..<<.........<<..>>.....>>..>>>>>>>>...........)))......>>>>>>.>>>...>>>>>>><<<<<<<<...>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<...((((...>>>>>>....<<<<...<<<<.>>>>...>>>>........<<<<<......>>>>>....>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<....<<..>>.....>>>>><<<<<<<<<<<<...<<<<.....>>>>...>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<..<......>...>>>>>........>>>>>>>>..>>>>>..........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<.<<<<.[[......<<<<.[[<<<<..<<<<..<<<.<<<<<.<<<<<<<<..>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>...>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<.................>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))))>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<<<<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>...>>>>..>..>>>>>>>. ((((((([.....((((((((((.....(((..(((((((((((((......((((((....[[[.))).....((((((...((.]]]......))......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((..(..((.(((((((((((.(((...(((.(......).)))[[(...).(((.....]])))...)))...))))))))))).))...)..)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((.....)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((........)))))...)[)))...(((.(((.(........).))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).(((((((...((((((((((.....(((...(((.((((..)))).)))..)).).....)))))).))).).)))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{..((()))....)))..))))).))...........]]].)....))))))))))...)))))))((((((((...))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))....((((...((((.))))..[)))).....(..((((((....))))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((...((((....]))))...))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..(......)...)))))........))))))))..)))))()........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..(((((((..(((.((......(((..((((((..(((((.(((.(((((.((((((.(()).))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..)).)))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(.(((((....))).)).)....))..))).)))))))[...(((((((...((((..((((((......(....).....)))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..)])))))(....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))..).)))))))). A. baumannii Ribosome-TP-6076 complex: Empty 70S; 23S ribosomal RNA 7ryh B 115 2.43 RF00001 URS00002D8B10_480119 35100868 0003735 0005840 480119 gcuggcgaccauagcaagagugaaccaccugaucccuucccgaacucagaagugaaaccucuuagcgcugaugguagugugggauuacccaugugagaguaagucaucgccagcu <<<<<<<<.....<<<<<<<.....<<<<<<...............>>>..>>>....>>>>>.>><<<.......<<<<<<<....>>>>>>>.......>>>..>>>>>>>>. (((((((......(((((((.....(((.((....(.....)....))...)))....))))).))(((.......(((((((....))))))).......)))...))))))). A. baumannii Ribosome-TP-6076 complex: Empty 70S; 5S ribosomal RNA 7s0s C 3119 3.05 RF02540,RF02541 URS0000BC467B_1772 35357969 0003735 0005840 1772 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<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<<......<<<<<<.[[.(((.>>>.....<<<<<<<..<<<)))..]].>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<.....>>..<<<<<<.....<<.....>>....>>>>>>...<<<....<<<<<<<<<..........(((((......>>>>>>>>>......<<<<..<.....<<<<<<<))))).>>>>>>><<<<<<.......<<<<<<.<<<<.<<<.....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>>>.....>...>>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..>>>......>>.>>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<<<<..>>>>.>>>>>..>>>>...<.<........>.>.<<<<<<....<<<.<<<<<<<<<<..<<<...<<<....>>>...>>>...<<....>>..<<<<.....>>>>....<<<<<<<....>>>>>>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<....<<<<<<<<.....<<<....<<<.<<<<.<...<<<<<....>>>>>.....>>>>>.>>>..>>.>.....>>>>>>>>.......>>>>>>>.>>..<<<<<<<<<<......>>>>>>.>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<.........<<<<.<<<..<<<.........>>>..>>>.........<<......>>...>>>>.....>>>>>>>>>.>>...........)))......>>>>>>.>>>...>>>>>>><<<<<<<<..>>>>>>>>....>>>>>><.<<<<<<<<<<......<<<<<<<<....>>>.>>>>>...>>>>>>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<.......<<<<..<<<<<<<<......<<<<.<<...<<<<<....<<<<<<<<....>>>>>>>>....>>>>>...>>.>>>>.....>>>>>>>>....>>>>.<<...<<<<<...<<<<..<<<..<<<<..<<<<<...((((...>>>>>.<<..<<<<...<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>...>>>>...>>...<<<......>>>.....>>>>...>>>...>>>>........>>>>>..>>....>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<<...<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<...<<<<....<<<.....>>>....>>>>..>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.<<<....<<<<<.<<<<<<...>>>>>>..>>>>>....>>>.>>>>>>>>>..>>>>><<<<<.........>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>>>>>>>>.....>.((..<<<<<......))>>>>>..<<<<<<<<.<<<.<<......<<<<<<<<<<..<<<<<.<<<.<<<<<.<<.<<<<<<<<<<<..............<<<<..<<.......<<<<<<<......>>>>>>>....>>............>>>>.....>>>>>>>>>>>.>>...<<<.<<<<<<......>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.<<..>>>>..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<.<<<<...<<.......>>...>>>>.>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))))>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<...>>>>>....<<<<.<<<<.......>>>>.....<<<.<<<<.<<<....<<<<<....>>>>>...>>>..>>>>..>>>...>>>>....>>>>.. ((((......((((((((((.....(((..(((((((((((((......((((((.[[.[[[.))).....((((((...(((]]]..]].)))......))))))...)))....(((....)))(((((((......))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))....((([...(((((((((..........[[[[[......)))))))))....(.((((.((...(.(((((((]]]]].))))))).(.(((.......((((((.((((.(((...(.((((......)))))[[(...).(((.....]])))...)))...))))))))))))).)..)...).).))))]....(((((((...[.......)))))))....).(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((..(((((((((..)))).)))))..)))).<.(.(........).).((((((....(((.((((((((((..(((...(((....)))...)))...((....))..((((.....))))....(((((((....)))))))....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......A))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([.((((((((.....(((....(((.((((....((((((....))))).)....)))).)))..)).).....))))))))....).]))))))).))..((((((((((......)))))).))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.((([.(((.........)))..))).....(]..((......)).).)))))...)))))))))).))...........]]].)....))))))))))...)))))))((((((((..))))))))....))))))(.((((((((((......((((((((....))).)))))...))))))))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]]((((((((((.(.....((((..(.(((((.......((((.((...((((((...((.((((......)))).))..).)))))...)).))))......))))).)....)))).((...(((((...((((..(((..((((..(((((....{{....))))).((..(((....(((((((((((.((.....))))))))).....))))..[.)))...))...(((......))).....))))...)))...))))(..)....)))))..))..).)))))))))))))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((...((((....((((..)])))....))))..))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((....((((..((.(((...))).))...))))....))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....))[[..(((((.....>]])))))..((((((((.(((.((......((((((((((..(((((.(((.(((((.((.((((((((((.(..(......[...((((...(.......((.(((((....))))).))....).....].......)))).)..).)))))))))).))...(((.((((((......)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.(.((((...((.......))...)))).)...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..a.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..(((((...)))))....((((.((((.......)))).....(((.((((.(((....(((((....)))))...)))..))))..)))...))))....)))).. M. tuberculosis ribosomal RNA methyltransferase TlyA bound to M. smegmatis 50S ribosomal subunit; 23S rRNA 7s0s i 118 3.05 RF00001 URS00000ACC0A_1772 35357969 0003735 0005840 1772 guuacggcgguccauagcggcagggaaacgcccggucccaucccgaacccggaagcuaagccugccagcgccgaugauacuacccauccggguggaaaaguaggacaccgccgaacac <<<.<<<<<<<.....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<.......<<<<<<....>>>>>>.......>>..>>>>>>>>>>.. (((.(((((((.....((((((((.....((((((...(.....)...))))..))....)))))).)).((.......((((((....)))))).......))..)))))))))).. M. tuberculosis ribosomal RNA methyltransferase TlyA bound to M. smegmatis 50S ribosomal subunit; 5S rRNA 7s1g A 76 2.48 RF00005 URS000044E875_562 35165456,31588918,29872003,20383002,32881101 0030533 0006412 562 gcccggauagcucaguagguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((...(.......[....).....((.......))........((.((..]....)).))))))))).... wild-type Escherichia coli stalled ribosome with antibiotic linezolid; tRNA(PHE) 7s1g C 1540 2.48 RF00177,RF01959,RF01960 URS0000D56C37_562 35165456,31588918,29872003,20383002,32881101 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<<....>>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<......>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((((((.(..).)))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..(.(...)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((((((..).))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..((.((((....)))).))....(....)...))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...((((((......(((..((...(((....)))...))....)))......))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... wild-type Escherichia coli stalled ribosome with antibiotic linezolid; 16S rRNA 7s1g I 2898 2.48 RF02540,RF02541 URS00004B0F34_562 35165456,31588918,29872003,20383002,32881101 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccuu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<...>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<...........>>...>>.........<<......>>...>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<.<<....>>.>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<..<<....>>...>>>>>..>....>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<..<<<............<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>...>>>..>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>.. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((.((...))..))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..)).)....(...((......)).).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((.((....)).))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((((((((...((............((.((..(((......((((((((....))))))))...)))............)).))...))...))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....((((((..((..]]]]..)).)))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).).....((.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..))....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))).. wild-type Escherichia coli stalled ribosome with antibiotic linezolid; 23S rRNA 7s1g J 118 2.48 RF00001 URS0000049E57_562 35165456,31588918,29872003,20383002,32881101 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))). wild-type Escherichia coli stalled ribosome with antibiotic linezolid; 5S rRNA 7s1h C 1540 2.35 RF00177,RF01959,RF01960 URS0000D56C37_562 35165456,31588918,29872003,20383002,32881101 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<<....>>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<......>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>.............>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<..<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>.........>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((((((.(..).)))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((.(....).))))......)).).....(((....)))....((((((..(......))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..((.((((....)))).))....(....)...))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...((((((......(((..((...(((....)))...))....)))......))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Wild-type Escherichia coli ribosome with antibiotic linezolid; 16S rRNA 7s1h I 2898 2.35 RF02540,RF02541 URS00004B0F34_562 35165456,31588918,29872003,20383002,32881101 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccuu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<<..>>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<...>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<.........>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<.<<....>>.>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<..<<<............<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>...>>>..>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>.. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((.((...))..))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(...((......)).).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((..........))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((((((((...((............((.((..(((......((((((((....))))))))...)))............)).))...))...))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....((((((..((..]]]]..)).)))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).).....((.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..))....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))).. Wild-type Escherichia coli ribosome with antibiotic linezolid; 23S rRNA 7s1h J 118 2.35 RF00001 URS0000049E57_562 35165456,31588918,29872003,20383002,32881101 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))). Wild-type Escherichia coli ribosome with antibiotic linezolid; 5S rRNA 7s1i A 76 2.48 RF00005 URS000044E875_562 35165456 0030533 0006412 562 gcccggauagcucaguagguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((...(.......[....).....((.......))........((.((..]....)).))))))))).... Wild-type Escherichia coli stalled ribosome with antibiotic radezolid; tRNA(PHE) 7s1i C 1540 2.48 RF00177,RF01959,RF01960 URS0000D56C37_562 35165456 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<<....>>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<......>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((((((.(..).)))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((((((..).))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))....(....)...))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Wild-type Escherichia coli stalled ribosome with antibiotic radezolid; 16S rRNA 7s1i I 2898 2.48 RF02540,RF02541 URS00004B0F34_562 35165456 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccuu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<<..>>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<...>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<.........>>>...>>.........<<......>>...>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<.<<....>>.>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<..<<....>>...>>>>>.>.....>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<..<<<............<<<<<..<<<<.....<<<<<<<<....>>>>>>>>..>>>>............>>>>>...>>>..>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>.. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((.((...))..))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(...((......)).).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((.((....)).))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((((((((...((............((.((..(((......((((((((....))))))))...)))............)).))..).)...))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....((((((..((..]]]]..)).)))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))).. Wild-type Escherichia coli stalled ribosome with antibiotic radezolid; 23S rRNA 7s1i J 118 2.48 RF00001 URS0000049E57_562 35165456 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))). Wild-type Escherichia coli stalled ribosome with antibiotic radezolid; 5S rRNA 7s1j C 1540 2.47 RF00177,RF01959,RF01960 URS0000D56C37_562 35165456 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<<....>>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<......>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<..<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>.........>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((((((.(..).)))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((((.......)))))))).....)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((.(((....))).)))....(....)...))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....))))))).....(((((.....)))))........)))).....).).)))...)).)))))....)))))))...)).)))))))).(...((((((......(((..((...(((....)))...))....)))......))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Wild-type Escherichia coli ribosome with antibiotic radezolid; 16S rRNA 7s1j I 2898 2.47 RF02540,RF02541 URS00004B0F34_562 35165456 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccuu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<<..>>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<...>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<.........>>>...>>.........<<......>>...>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<..<<....>>..>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<..<<....>>...>>>>>..>....>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<..<<<............<<<<<..<<<<.....<<<<<<<<....>>>>>>>>..>>>>............>>>>>...>>>..>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>.. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((.((...))..))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(...((......)).).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((.((....)).))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(...((((....))))....))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((((.(((...((............((.((..(((......((((((((....))))))))...)))............)).))..)..)..))).))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....((((((..((..]]]]..)).)))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))).. Wild-type Escherichia coli ribosome with antibiotic radezolid; 23S rRNA 7s1j J 118 2.47 RF00001 URS0000049E57_562 35165456 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))). Wild-type Escherichia coli ribosome with antibiotic radezolid; 5S rRNA 7s1k A 76 2.42 RF00005 URS000044E875_562 35165456 0030533 0006412 562 gcccggauagcucaguagguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((...(.......[....).....((.......))........((.((..]....)).))))))))).... Cfr-modified Escherichia coli stalled ribosome with antibiotic radezolid; tRNA(PHE) 7s1k C 1540 2.42 RF00177,RF01959,RF01960 URS0000D56C37_562 35165456 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<<....>>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<......>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((((((.(..).)))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((((.......)))))))).....)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((((((..).))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))....(....)...))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Cfr-modified Escherichia coli stalled ribosome with antibiotic radezolid; 16S rRNA 7s1k I 2898 2.42 RF02540,RF02541 URS00004B0F34_562 35165456 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccuu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<...>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<.........>>>...>>.........<<......>>...>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<.<<....>>.>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>.>......>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<..<<<............<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>...>>>..>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>.. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((.(...))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((.((...))..))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(...((......)).).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((.((....)).))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((((((((...((..(.........((.((..(((......((((((((....))))))))...)))............)).)))..))...))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....((((((..((..]]]]..)).)))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).).....((.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..))....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))).. Cfr-modified Escherichia coli stalled ribosome with antibiotic radezolid; 23S rRNA 7s1k J 118 2.42 RF00001 URS0000049E57_562 35165456 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))). Cfr-modified Escherichia coli stalled ribosome with antibiotic radezolid; 5S rRNA 7s7c D 27 3.62 URS00023359C8_32630 35688134 32630 ggcgcgcgccaaaaauuuuaaaaaaaa ........................... ........................... Human Nuclear Exosome Targeting (NEXT) complex bound to RNA (substrate 2); RNA (30-MER) 7s7c L 10 3.62 URS00023359C8_32630 35688134 32630 ggcgcgcgcc .......... .......... Human Nuclear Exosome Targeting (NEXT) complex bound to RNA (substrate 2); RNA (30-MER) 7sa4 1 2903 2.55 RF02541 URS00021ED9BC_562 35858322 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaacccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<.......>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<..<<.......<<<<<<<<....>>>>>>>>....>>............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<.<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>...>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......((((.((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))).))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((((.........))).))...)))).)))..)).).....))))))).))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..((((.......))))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((..((....))..)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((.(...((.(..........((((..(((......((((((((....))))))))...)))............)))).).))...).)))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(.(((((....))).)).)....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Damaged 70S ribosome with PrfH bound; 23S ribosomal RNA 7sa4 2 1534 2.55 RF00177,RF01959,RF02542,RF01960 URS000081169C_562 35858322 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugangucgnaacaagguaaccguaggngnnccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<..<<<<<<<<<......>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<.<<<....>>>.>>..............>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ........((((..[.[[[[.)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((........))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..........)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((((.......)))))))).....)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))..]]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...((((((....))))))..............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Damaged 70S ribosome with PrfH bound; 16S ribosomal RNA 7sa4 4 120 2.55 RF00001 URS0000049E57_562 35858322 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Damaged 70S ribosome with PrfH bound; 5S ribosomal RNA 7sa4 5 77 2.55 RF00005 URS000041AF00_562 35858322 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Damaged 70S ribosome with PrfH bound; P-tRNA, E-tRNA 7sa4 6 77 2.55 RF00005 URS000041AF00_562 35858322 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Damaged 70S ribosome with PrfH bound; P-tRNA, E-tRNA 7sa4 7 13 2.55 35858322 562 aaaauguucuaca ............. ............. Damaged 70S ribosome with PrfH bound; mRNA 7sbb X 33 3.1 URS00023359B1_32630 35595728 32630 aggcauugaaagcgaccaccaggggcacaacaa ................................. ................................. Structure of type I-D Cascade bound to a ssRNA target; ssRNA target 7sbb Z 43 3.1 URS00023359B2_1148 35595728 1148 acugaaacgauuguugugccccuggcggucgcuuucaaugccu ........................................... ........................................... Structure of type I-D Cascade bound to a ssRNA target; crRNA 7sfr A 3118 2.6 RF02541 URS00005E0FC6_1773 36827973 0003735 0005840 1773 aagugucuaagggcgcaugguggaugccuuggcaucgagagccgaugaaggacgugggaggcugcgauaugccucggggagcugucaaccgagcguggauccgaggauuuccgaauggggaaacccagcacgagugaugucgugcuacccgcaucugaauauauagggugcgggagggaacgcggggaagugaaacaucucaguacccguaggaggagaaaacaauugugauuccgcaaguaguggcgagcgaacgcggaacaggcuaaaccgcacgcauggguaaccggguagggguugugugugcgggguugugggaggauaugucucagcgcuacccggcugagaggcagucagaaagugucgugguuagcggaaguggccugggauggucugccguagacggugagagcccgguacgcgaaaacccggcaccugccuaguaucaauucccgaguagcagcgggcccguggaauccgcugugaauccgccgggaccacccgguaagccuaaauacuccucgaugaccgauagcggauuaguaccgugagggaauggugaaaaguaccccgggaggggagugaaagaguaccugaaaccgugugccuacaauccgucagagccuccuuuuccucuccggaggaggguggugauggcgugccuuuugaagaaugagccugcgagucagggacaugucgcaagguuaacccgugugggguagccgcagcgaaagcgagucugaauagggcgacccacacgcgcauacgcgcgugugaauaguggcguguucuggacccgaagcggagugaucuacccauggccagggugaagcgcggguaagaccgcguggaggcccgaacccacuuagguugaagacugaggggaugagcuguggguaggggugaaaggccaaucaaacuccgugauagcugguucuccccgaaaugcauuuaggugcagcguugcgugguucaccgcggagguagagcuacuggauggccgauggguuacugacgucagccaaacuccgaaugccgugguguaaagcguggcagugagacggcgggggauaagcuccguacgucgaaagggaaacagcccagaucgccggcuaaggcccccaagcgugugcuaagugggaaaggaugugcagucgcaaagacaaccaggagguuggcuuagaagcagccacccuugaaagagugcguaauagcucacuggucaagugauugugcgccgauaauguagcggggcucaagcacaccgccgaagccgcggcacauccaccuugugguggguguggguaggggagcgucccucauucagcgaagccaccgggugaccggugguggagggugggggagugagaaugcaggcaugaguagcgacaaggcaagugagaaccuugcccgccgaaagaccaaggguuccugggccaggccaguccgcccagggugagucgggaccuaaggcgaggccgacaggcguagucgauggacaacggguugauauucccguacccgugugugggcgcccgugacgaaucagcgguacuaaccacccaaaaccggaucgaucacuccccuucggggguguggaguucuggggcugcgugggaacuucgcugguaguagucaagcgaaggggugacgcaggaagguagccguaccagucagugguaacacuggggcaagccgguagggagagcgauaggcaaauccgucgcucacuaauccugagaggugacgcauagccgguugaggcgaauucggugauccucugcugccaagaaaagccucuagcgagcacacacacggcccguaccccaaaccgacacagguggucagguagagcauaccaaggcguacgagauaacuaugguuaaggaacucggcaaaaugcccccguaacuucgggagaagggggaccggaauaucgugaacacccuugcggugggagcgggauccggucgcagaaaccagugaggagcgacuguuuacuaaaaacacagguccgugcgaagucgcaagacgauguauacggacugacgccugcccggugcuggaagguuaagaggacccguuaacccgcaagggugaagcggagaauuuaagccccaguaaacggcggugguaacuauaaccauccuaagguagcgaaanuccuugucggguaaguuccgaccugcacgaauggcguaacgacuucucaacugucucaaccauagacucggcgaaauugcacuacgaguanagaugcucguuacgcgcggcaggacgaaaagaccccgggaccuucacuacaacuugguauugauguucgguacgguuuguguaggauaggugggagacugugaaaccucgacgccaguuggggcggagucguuguugaaauaccacucugaucguauugggcaucuaaccucgaacccugaaucggguuuagggacagugccuggcggguaguuuaacugnggcgguugccuccuaaaauguaacggaggcgcccaaagguucccucaaccuggacggcaaucagguggcgaguguaaaugcacaagggagcuugacugcgagacuuacaagucaagcagggacgaaagucgggauuagugauccggcacccccgaguggaaggggugucgcucaacggauaaaagguaccccggggauaacaggcugaucuuccccaagaguccauaucgacgggaugguuuggcancucgaugucggcucgucgcauccuggggcuggagcaggucccaaggguugggcunuucgcccauuaaagcggcacgcgagcuggguuuagaacgucgugagacaguucggucucuauccgccgcgcgcgucagaaacuugaggaaaccugucccuaguacgagaggaccgggacggacgaaccucuggugcaccaguugucccgccaggggcaccgcuggauagccacguucggucaggauaaccgcugaaagcaucuaagcgggaaaccuucuccaagaucagguuucucacccacuuggugggauaaggccccccgcagaacacggguucaauaggucagaccuggaagcucaguaauggguguagggaacuggugcuaaccggccgaaaacuu <<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<<......<<<<<<.[[.(((.>>>.....<<<<<<<..<<<)))..]].>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<....<<<<<<<<<<......<<((((((>>...>>>>>>>>>>......<<<<<<<<...<<<<<<<.)))))).>>>>>>><<<<<.......<<<<<<.<<<<.<<<.....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>>....>>>..>>>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..>>>......>>.>>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>..<....<<<<..<<<.<<<<<<<<.....>>.>>>>>>.>>>..>>>>...<.<........>.>.<<<<<<....<<<.<<<<<<<<<<..<<<...<<<....>>>...>>>...<<....>>..<<<<.....>>>>.....<<<<<<<......>>>>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<....<<<<<<<<.....<<<....<<<.<<<<....<.....>....>>>>.>>>..>>.>.....>>>>>>>>....>>>>>>>.>>..<<<<<<<<<<......>>>>>>.>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..<<<.........>>>..>>>.........<........>...>>>>>....>>>>>>>>>.>>...........)))......>>>>>>.>>>...>>>>>>><<<<<<<<<<....>>>>>>>>>>....>>>>>><.<<<<<<<<<.......<<<<<<<<....>>>>>>>>....>>>>>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<.<<.....<<<<....<<<<<<......<<<<.<<...<<<<<.<..<<<<.<<<......>>>.>>>>.>.>>>>>...>>.>>>>.....>>>>>>......>>>>.<<..<<<<<<...<<<<..<<<..<<<<..<<<<<...((((...>>>>>.<<..<<<....<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>....>>>...>>...<<<......>>>.....>>>>...>>>...>>>>........>>>>>>.>>..>>.>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<...<<.......<<.....>>.........>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.<<<....<<<<<.<<<<....>>>>..>>>>>....>>>.>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.((..<<<<<......))>>>>>>.<<<<<<<<.<<<.<<......<<<<<<<<<<..<<<<<..<<.<<<<<.<<<<<<<<<<<<<.<.............................<...<.......>....>...........................>.>>>>>>>>>>>>>...<<<.<<<<<<......>>>>>>>>>....>>>>>.>>...>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.<<..>>>>..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<.<<<<...<<.......>>...>>>>.>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>>>>>>>>>....<<<<<<<...<<<...<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))))>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>..>>>.......>>>>>>>..<<<<.....>>>>....<<<<.<<<<.......>>>>.....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>> (((.......((((((((((.....(((..(((((((((((((......((((((.[[.[[[.))).....((((((...(((]]]..]].)))......))))))...)))....(((....)))(((((((......))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((.((((.....(([[[[[[))..)))).))))))....(.((((.(((...((((((..]]]]]]..))))))(((((.......((((((.((((.(((...(.((((......)))))[[(...).(((.....]])))...)))...)))))))))))))))....)))...))))]....(((((((...[.......)))))))....).(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((..(((.((((..((.....))...)))).)))..)))).<.(.(........).).((((((..(.(((.((((((((((..(((...(((....)))...)))....(....)...((((.....)))).....(((((((......))))))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.((((........A.)))))))..).))))))))).(.(((.....)))...)..))))))......).))).(((((.....(((((....)))))(((((((((....((((((((.....(((....(((.((((....(.....)....)))).)))..)).).....))))))))....))))))).))..((((((((((......)))))).))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((.(.....{...(((.(((...(...........)...))).....(..............).))).....).)))))))).))...........]]].)....))))))))))...)))))))((((((((((....)))))))))).....)))))(.((((((((((......((((((((....))))))))...))))))))))..).....))))))(......((.....((((((.......))))))((((....((((..((...((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(.(((........))).)]](((((((((.((.....((((....(((((..(....((((.((...((.((.(...(((.(((......))).)))..).)).))...)).))))....).)))))......)))).((...(((((...((((..(((..((((..(((((....{{{...))))).((..(((....(((((((((((.((.....))))))))).....))))..[.)))...))...(((......))).....))))...)))...))))(..)....)))))..))..)).)))))))))))))..)).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((....(........((..)]).........)..))))))(...).......((((((((..].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((....((((..((((....))))...))))....))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))....).))))))).)..))).)))))))).)))))).....))[[..(((((.....>]])))))..((((((((.(((.((......(((((((.((..(((((..((.(((((.(((((.((..(((.(................................................................(...).....).)))..)).)))))...(((.((((((......)))))))))....))))).))...)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......)).)..))))))......(((((.(.(.((((...((.......))...)))).)...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..a.))..)))))))))))[..<(((((((...(((...(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....)))..)))..]....)))))))..((((....>))))....((((.((((.......)))).....((((((((.(((....(((((....)))))...)))..))))).)))...)))).....))) Unmethylated Mtb Ribosome 50S with SEQ-9; 23S rRNA 7sfr B 115 2.6 RF00001 URS00005330B1_1773 36827973 0003735 0005840 1773 uuacggcggccacagcggcagggaaacgcccggucccauuccgaacccggaagcuaagccugccagcgccgaugauacugccccuccggguggaaaaguaggacaccgccgaaca .<.<<<<<<.....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<.......<<<<<<....>>>>>>.......>>...>>>>>>.>.. .(.((((((.....((((((((.....((((((...(.....)...))))..))....)))))).)).((.......((((((....)))))).......))...)))))).).. Unmethylated Mtb Ribosome 50S with SEQ-9; 5S rRNA 7sfr a 1519 2.6 RF00177,RF01959,RF02542,RF01960 URS00002C0A67_1773 36827973 0003735 0005840 1773 uggagaguuugauccuggcucaggacgaacgcuggcggcgugcuuaacacaugcaagucgaacggaaaggucucuucggagauacucgaguggcgaacgggugaguaacacgugggugaucugcccugcacuucgggauaagccugggaaacugggucuaauaccggauaggaccacgggaugcaugucuugugguggaaagcgcuuuagcggugugggaugagcccgcggccuaucagcuuguugguggggugacggccuaccaaggcgacgacggguagccggccugagaggguguccggccacacugggacugagauacggcccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagcgacgccgcgugggggaugacggccuucggguuguaaaccucuuucaccaucgacgaagguccggguucucucggauugacgguagguggagaagaagcaccggccaacuacgugccagcagccncgguaauacguagggugcgagcguuguccggaauuacugggcguaaagagcucguaggugguuugucgcguuguucgugaaaucucacggcuuaacugugagcgugcgggcgauacgggcagacuagaguacugcaggggagacuggaauuccugguguagcgguggaaugcgcagauaucaggaggaacaccgguggcgaaggcgggucucugggcaguaacugacgcugaggagcgaaagcguggggagcgaacaggauuagauacccugguaguccacgccguaaacgguggguacuagguguggguuuccuuccuugggauccgugccguagcuaacgcauuaaguaccccgccuggggaguacggccgcaaggcuaaaacucaaaggaauugacgggggcccgcacaagcggcggagcauguggauuaauucgaunnaacgcgaagaaccuuaccuggguuugacaugcacaggacgcgucuagagauaggcguucccuuguggccugugugcagguggugcauggcugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuugucucauguugccagcacguaaugguggggacucgugagagacugccggggucaacucggaggaagguggggaugacgucaagucaucaugccccuuauguccagggcuucacacaugcuacaauggccgguacaaagggcugcgaugccgcgagguuaagcgaauccuuaaaagccggucucaguucggaucggggucugcaacucgaccccgugaagucggagucgcuaguaaucgcagaucagcaacgcugcggugaauacguucccgggccuuguacacaccgnccgucacgucaugaaagucgguaacacccgaagccaguggccuaacccucgggagggagcugucgaaggugggaucggcgauugggacgaagucgnaacaagguagccguaccngnnggugcggcuggauc ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<..<<.<<<......>>..>>>>..>>>>>......<<........<<<<<<<..<<...<<<<<<<<<<<<..<..<<<<<......>>>>>.....>>>>>.....<<<<<<<<<<....>>>>>>>>>>.....<<......>>>>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<<<<<<.......>.>>>>>.......>>>>>....>..<<<<<(((...<<<<<.....<..))).>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<.....<<<<<<<.....>>>>>>>...>>>>>>>..>>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<<..<<<......>>>.....>>>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<.<........>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<.......<<<<<..<<<<.<.<....>.>.>>>>............>>>>>..<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<...<<<......>>>.>.....>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<..<<<<....<.<<<<..<<<..<<....>>.>>>.>>>>.>...>>>>..>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... ....(((...[.[[[...))).((((.(((((..(((((((((....(((.(((..(((..((.((..(.(..(....)....))))..)))))......(((.......(((((((..((...((..(((..(((.....(((.((....)).)))......))).......((((.((((....)))).))))......((......)).)))..))..))))))))).(((....(((...(((((((.......))))))).)))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(...(.((.(.....)..)).)...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((.....(((((((.....)))))))...))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((.((......))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(....(((..(..(((...(....)...)))...........)...))).).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((...(((((((...((..((........))))....)))))))..(..(((((.....))))).....)....)).....).).)))...)).)))))....)))))))...)).)))))))).(...((((((......(((..((....((....))....))....)))......))))))......(....(((((((........)))))))....)..)..))))).....(((((((..........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((..((((....(.((((..(((..((....)).))).)))).)...))))..))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Unmethylated Mtb Ribosome 50S with SEQ-9; 16S rRNA 7ss9 3 1539 3.9 RF00177,RF01959,RF01960 URS000080DDC0_83333 34903725 0003735 0005840 83333 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[[((((.>>>>.<<<<.<<<<<...<<<<<<<.....<<<.<<<..<<<..<<.<<...<.<.<<...........>>>..>.>>..>>>>>......<<.......<<<<<<...<<...<<<<<<<...<.<....<<<<<......>>>>>......>>.......<<<....>>.>...<.<.<.<.<<....>>>>..>>.>>>>>>>..>>..>>>>>><<<....<<<..<<<<<.<.........>.>>>>>>>>......>>>..<<<.<<<<....>>>>....>>>.>>.<<<<.<<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<...<<<.<......>.>.>>>>..>>.>>>>>...<<<<.......<<<....>>>......>>>>......<<<<......<..<<<<<<<.......>>>>>>>..>........>>>>........<<<<<((....<<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<..<.<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>..>>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<....<<<......>>>.......>>>>>>>...........<<....>>.>>>>>>>..>>>.>>>>>...>>>..>.>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>.>>>.>>>.<<<.......<<<....>>>.....>>>..)))).]]<<<<.<<<<<<<.....<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<.<<....>>.>>>>.............>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<..<<<<<<<...<....<<.....>>..>....>>>>>>>.....<<...........>>.........>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<......<<<..<<...<<<....>>>...>>....>>>......>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>.....<<<<<<<.........>>>>>>>...........>>>>>>>>>>.>........<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<....<....>...>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((.(..............)..)))))..)))))......(((......(((((((..((...((...((.(.((.....((((........))))......)).).....(((....)))....((((((..(......))))))).))...))..)).)))))))(((....((...((((((((.......)))))))).))......)))...(((.(((....)))....))).))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((..((((...(....(((((((.........))))))).....)....)))).....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((.(.(.(((.(((.(((.((((((((((......((((((.....))))))....))))))))..))))).)))..(((((((((...((((((......((((((....((........)).......))))))............((....))..))))))..))).)))))..))))..)).))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((.(((.....))).))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...((((((...(((((((....)))))))..............)))).))).((.((....((((((.(....(((((((((....)))...(((......)))...)))))).....(((..(((((((...((..(((.....)))))....))))))).....((.(.......).)).........))).....).).)))...))..))))....))))))))..)).)))))))).....((((((......(((..((...(((....)))...))....)))......))))))...........(((((((........)))))))..........))))).....(.(((((.........))))).)......))...)))))))))).))..(.(..((.(.((((.(((..((((.((.((((....((((((.(((....(....)...)))))))))...)))).)).))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Late translocation intermediate with EF-G partially dissociated (Structure V); 16S rRNA 7ss9 1 2903 3.9 RF02540,RF02541 URS0000BC4674_83333 34903725 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugucgaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<.<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[.<<......<<<<<<....(((.>>>.....<<<<<<<..<<.))).....>>......>>>>>>>...>>>....<<<....>>><<<<<<......>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<......<<<<<<<<<<<...<<<....<<<........>>>.((......<<<.....))>>>...>>>.....>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<.>>>>>..>>>.......].>>>>>>>.]]...............<<....>>....]].........<<<.......>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<............>.<<<<<<.....<<<<<.<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<.........>>.....>>>>>>.>>>>>...<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<.<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>..>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<..................................<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<..<<....>>..>>>>>....>>>>>>..<<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>>.>>>>>........>>>>>>.<.....<<.....<<<<.<........>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>...<.<...........>>.))<<<<<<<<<<<<<...<<<<....<<.<..<<<..<<<<<<<<<<<.....{....>>>>>>....<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>........<<<<<....>>>>>....>>>>>...>>>....>>.>........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<................<<<<.....<..>......>>>>.<<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<..<<<..<<<<<<<..<<<....<...<.<<<..<......>...>>>.>..>.....>>>>>>>>..>>>>><<<<<.........>>>>>........<...........<<<<<.......>>>>>.....>.....>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>...>.......<<<<<........>>>>>..<<<<<<<<.<<<.[[......<<<<.[.<<<<..<<<<<.<.<.<<<<..<<<<<<<<<<..<<.............<<<<<..............<<<<......>>>>.....................>>>>>....>>..>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>.....>>>>.>.>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<.........>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((...>>>..))>>>>>>>.............>>>>...]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<.<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>...>...>>>.>>....<<<<<<<....>>>.>>>>....]]..>>>>>>>>>>>....<<<<<<....<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<..<<<<<<<<<<<..}...>>>>>..>>>>>>..>>>>.>>>>>...<<<.<..<<<<.............>>>>...>>>>.>>>>........>>>>>>..<<<<<.....>>>>><....<<..<<<<.........>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>.>>>. ((.(((((......((((.(((((.....(((..(((((((((((((......((((((....[[[.))).....((((((...(((]]]....))).......))))))...)))....(((....)))((((((......)))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...(((..((((......((((.((((...(.(((...(((((......)))))[[......(((.....]])))...)))...)...)))).))))...)))).........(.(((((..[......))))).).......(((((].{{.{)))))..)))......)).))))))).))...............((....))....)).........((((.....)))).............).....))))).)))).......((((..((((((....))))))..)))).{.(.(........).).((((((....(((((.(((((((..(((...((.....))...)))...((....))..((((.....)))).....))))))).)))))..((.(...((((((.....((((((((((.(((.....(((((......))))).....{)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((...(((((((((.....(((....((...((...((..((.......))...))...))...))...)).).....)))))).)))...))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[.....((((((.....(.....((..((.((..(((.....<.(((((.(....(.............)....).....(..(((......)))).)))))...)))..)).)).))...........]]].)...)))))).)))...)))))))((((...(......)...))))....))))))(.(((((....((......(((.(((......))).)))...))...)))))..).....)))))).......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((...(((...(((....)))...)))...)))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((.(...[[[.)..)))))((..((((...((((((((((((.((.....))))))))))..))))...))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(............(.(((....(.[..).....))).).(((((.....(((...((((.....))))...)))...))))).(...).......(((((.(((.}.((.........))...(((((((.....(((....))).......))))))).]((((.(((..((.((((..(((........(((((..((....))...)))))........)))))))...)))))((((...........))))........((..........(((((.......)))))..)..)....))))...)).).)))))....))).)))))))).))))))........[..(.(((.....}].))).)..(((.((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((.((..((..............((.(.............((............))....................).)).....))..)).)))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[))).(((((..........]))))).(.((...(((((((...(((((.........))))).....((.[.[[[))....)))))))...((((..((.(..<.).))..)))).(((....))).))]]].].....((.((((.((..}.}}..)))))).)).....)>......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(((((((....))).))))....))..))))))).)))....(((((((...((((..((.((((.....(....)....)))).)).(((((...((((...(((((((((((]]].))))))..)))))...)))).)))))...(((....((((.....>.......))))....))).)))).......)))))))(.((.((.....)).))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).)))))).)). Late translocation intermediate with EF-G partially dissociated (Structure V); 23S rRNA 7ss9 2 120 3.9 RF00001 URS00008116C5_83333 34903725 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<........<<<<<<<...>>>>>>>........>>...>>>>>>>>>>. ..((((((((.....((.(((((....(((((((.............))))..)))...)))))..)).((.......((((((((...)))))))).......))...))))))))... Late translocation intermediate with EF-G partially dissociated (Structure V); 5S rRNA 7ss9 6 77 3.9 RF00005 URS000041AF00_83333 34903725 0030533 0006412 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(((((.......)))))))))))..... Late translocation intermediate with EF-G partially dissociated (Structure V); tRNA fMet 7ss9 4 20 3.9 34903725 83333 aggagguaaaaaugccaagu .................... .................... Late translocation intermediate with EF-G partially dissociated (Structure V); mRNA 7ss9 5 77 3.9 RF00005 URS00002E063F_83333 34903725 0030533 0006412 83333 cggcgaguagcgcagcuugguagcgcaacugguuugggaccagugggucggagguucgaauccucucucgccgacca .<<<<<...<<<<.........>>>>.<<<<<<.....>>>>>>.....<..<<.......>.>.>.>>>>>..... .((((((..((((.........))))..(((((.....))))).......((((.......)))).))))))..... Late translocation intermediate with EF-G partially dissociated (Structure V); tRNA Pro 7ssd 3 1539 3.3 RF00177,RF01959,RF01960 URS000080DDC0_83333 34903725 0003735 0005840 83333 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<..........>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<.<...<<<<<<......>>>>>.>....>>.>.....<<<....>>>....<<<<<.<.<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>.....<<<<<......<<<<<<<<<<.......>>>>>>>>.>>.......>>>>>.......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<.<.<<<.<<<<<<..<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>.>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>..>>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<.....>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<..<<<<...<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>.............>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<..<<<<<<<...<....<<.....>>..>....>>>>>>>.....<<.<<.....>.>>>.........>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<.....<<<<<<........>>>>>>.....>......>>>>.....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......(((...[.[[[...))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((..(............)...)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((.(....).))))......)).).....(((....)))....((((((..(......))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).......(((...(((((....)))).))))..)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.((((((..((((((((((......((((((.....))))))....))))))))..)).))))))..(((((((((....(((((((....(((((((...((........))......)))))))....).......((....)).))))))...))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((.(..((((((((((......((........))........(.(((((((..(...(((((((...((((((....))))))..............))))).))).((.((....((((((.(....(((((((((....)))...(((......)))...)))))).....((...(((((((...((..(((.....)))))....)))))))..(..((((.......)))).....)....)).....).).)))...))..))))....))))))))..)).)))))))).(...((((((......(((..((...(((....)))...))....)))......))))))......(.....((((((........)))))).....)..)..).))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((...(((((((((((....((((((.((((..((....)).))))))))))...)))))))))))...))).))))..).))...)..)..(((((((((....)))))))))}........... Mid translocation intermediate with EF-G bound with GDP (Structure IV); 16S rRNA 7ssd 1 2903 3.3 RF02540,RF02541 URS0000BC4674_83333 34903725 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugucgaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>...[.....<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<....<.<<<<<<<<<<<<<.<<<....<<<........>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>..>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))....].]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<....<...<<<.........>>>...>.........<<<......>>>....>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<..<<....>>..>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<.<.<<<...<<<....>>>...>>>..>>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<.....<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>..........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<....<.<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<<.<<....>>..>>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<.<............<<.<<..<<.......<<<<<<<......>>>>>>>....>>............>>.>>..>.>..>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<.............>>>>...>>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).((((((((...........)))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......((((((((((.((.(((...(((((......)))))[[......(((.....]])))...)))...)).))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...).)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((...(((((((((.....(((...(((.((((...((..((.......))...))...)))).)))..)).).....)))))).)))...))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((.(...(..(.((.......)).)..).......(...((......)).).).)))...)))..))))).))...........]]].)...))))))))))...)))))))(((((..(......)..)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..(((((((((((....{{{...))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(.(((....))).)...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((....(((....])))....)))...))))).)...........(((((((((...((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((((.((...(..............((..(............((...(......)...))...................)..)).....)...)).))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......((((.((.(((..(((((((((......))))))..))).(((((.....))))).....))).)..)...))).).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....(((.((((..((.....((((....))))....))...))))..))).....))..).))))))))). Mid translocation intermediate with EF-G bound with GDP (Structure IV); 23S rRNA 7ssd 2 120 3.3 RF00001 URS00008116C5_83333 34903725 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<........<<<<<<<...>>>>>>>........>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Mid translocation intermediate with EF-G bound with GDP (Structure IV); 5S RNA 7ssd 6 77 3.3 RF00005 URS000041AF00_83333 34903725 0030533 0006412 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(((((.......)))))))))))..... Mid translocation intermediate with EF-G bound with GDP (Structure IV); tRNA fMet 7ssd 4 16 3.3 34903725 83333 aggaggaaugccaagu ................ ................ Mid translocation intermediate with EF-G bound with GDP (Structure IV); mRNA 7ssd 5 77 3.3 RF00005 URS00002E063F_83333 34903725 0030533 0006412 83333 cggcgaguagcgcagcuugguagcgcaacugguuugggaccagugggucggagguucgaauccucucucgccgacca .<<<<<<..<<<<.........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).((((((.....)))))).....(((((.......)))))))))))..... Mid translocation intermediate with EF-G bound with GDP (Structure IV); tRNA Pro 7ssl 3 1539 3.8 RF00177,RF01959,RF01960 URS000080DDC0_83333 34903725 0003735 0005840 83333 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<<....>>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<.<......<<<......>>>........>>.>.....<<<....>>>....<<<<<.<.<......>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<.<<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<......>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>.....<<<<<........<<<<<<<<.......>>>>>>>>..........>>>>>.......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<..<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>.....<<<<<<<...<<<<<<<....<<<<<<<<.<.<<<......>>>.....>>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>....>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<.<<<<.......>>>>.>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]..<<<.<<<<<<<....<<<<<<..<<<<<<<<<<............................<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<..<<<<<<....<...<<<.....>>>.>.....>>>>>>.....<<<<<.....>>>>>.........>>>.......>.>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<..<.<<<<<<<........>>>>>>>>...>.....>>>>>>....<<<<<<<.........>>>>>>>...........>>>>>>>>>>..........<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((..(.(.......)..)...)))))..)))))......(((.......((((((..((...((((((..(.((.....(((((......)))))......)).).....(((....)))....((((((..(......)))))))..))))))..)).)))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).......(((...(((.(....).)).))))..)).))))))..(((.......((((....))))......)))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[....((((.....((.]]])).......)))).)))))..)))))))))..........((([[...(.((((...(((.((((((..((((((((((......(((.((.....)).)))....))))))))..)).))))))..(((((((((...((((((((....(((((.(...((........))......).)))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((.(((.((((.....)))).))).)))...((..]])).....)))))))))).(((......((((....))))....)))...]]].]((((..(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...((((((....))))))..............))))).))).((.((....((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..((.((.....)).)).....)..)))).....).).)))...))..))))....)))))))...)).)))))))).....(.((((......(((..((...(((....)))...))....)))......)))).)......(....(((.(((........))).)))....).....))))).....(((((((.........)))))))......))...))))))).)).))..(....((.(.((((..((..(((..(..((((....((.(((.((.(..((....)).).))))).))...))))..)..)))..))..))))..).))......)..(((((((((....)))))))))}........... Pre translocation intermediate with EF-G bound to GDP and Pi (Structure III); 16S rRNA 7ssl 1 2903 3.8 RF02540,RF02541 URS0000BC4674_83333 34903725 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugucgaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[.<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<.)))..]..>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>....<<<<<.....<<....>>......>>>>>...........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<..<<<....<<<........>>>.((......<<<.....))>>>...>>>....>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..))).......].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<<..>>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<...<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>......>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<.<..<<<<<<<<<.......<...<<<.<<<<...<<<<<<<.....>>>>>.>>...>>>>.>>>..>........>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<....<<<(((.....<<<<<<...........<<..<<<<<..<<........<<.....<....<<.........>.>...>.........<<<......>>>.....>>....>>..>>>>>.>>...........))).....>>>>>>.>>>....>>>>>><<<<<............>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>...<<<<........>>>>.))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....[[....>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>....>>>>........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<....<<..>>.....>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<<.<<....>>..>>>>>>.>......>>>>>>>>..>>>>><<<<<<.......>>>>>>........<............<<<<.......>>>>......>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<.<<...........<................<.<<<<<....>>>>>.>.......................>..>>.>.>>>>>>>>>>>...<<<.<<<<<.......>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>..>..>>>.>.......<<<<<.<.<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>...>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.]].>>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<.........>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((.(((((.........))))).))).))...((((((.........[.........))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[......(((.....]])))...)))...)))))))))))))...))))...)....(((((((...[.......)))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((((..)))))))..)))).[.(.(........).).((((((......(((((((((((..((....((.....))....))...((....))..((((.....)))).....)))))))))))....((.(...(.((((.....((((((.(((.((.(...((((((......))))))...)[.))...(((.(((((........))))))))..).)).)))))).(.((.......))...)..)))).)......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.(((....(.(((.........)))..)....))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((.((..(((.....{.(((.(...(..(.(.........).)..).......(..(((......)))).).)))...)))..)).)).))...........]]].)...))))))))))...)))))))(((((..(......)..)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((.(<((((((...((.....)).)))))))...[[(((.(((...(((...(((....)))...)))...)))..(((((........)))))]](((((((((((((...((((....((((..(((..(((((((((((....{{{...))))))((...(((...(((.((((((((.((.....))))))))))...)))..[)))....))(..(((.(....).)))...))))))...)))...))))(..).....))))...))....))))))))))).))).>)).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))....((((((.....(((....))).......))))))..}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.(....(.........((......(..........(((((....))))).......)................)))....).)))))))))))...(((..(((((.....))))).)))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....((.((((.((..]]]]..)))))).)).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Pre translocation intermediate with EF-G bound to GDP and Pi (Structure III); 23S rRNA 7ssl 2 120 3.8 RF00001 URS00008116C5_83333 34903725 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa .<<<<<<<<<.....<<<<<<<.....<<<<<<<.............>>>>..>>>....>>>>>.>>.<<........<<<<<<<...>>>>>>>........>>...>>>>>>>>>.. (.((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((.(((((...))))).)).......))...)))))))).). Pre translocation intermediate with EF-G bound to GDP and Pi (Structure III); 5S rRNA 7ssl 5 77 3.8 RF00005 URS00002E063F_83333 34903725 0030533 0006412 83333 cggcgaguagcgcagcuugguagcgcaacugguuugggaccagugggucggagguucgaauccucucucgccgacca ..<<<<...<<<<.........>>>>..<<<<<.....>>>>>.......<<<.........>>>..>>>>...... ..(((((..((((.........)))).(((((.......)))))......((((.......)))).)))))...... Pre translocation intermediate with EF-G bound to GDP and Pi (Structure III); tRNA Pro 7ssl 4 19 3.8 34903725 83333 aggagguaaaaaugccaag ................... ................... Pre translocation intermediate with EF-G bound to GDP and Pi (Structure III); mRNA 7ssl 6 77 3.8 RF00005 URS000041AF00_83333 34903725 0030533 0006412 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>.>....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(((((.......)))))))))))..... Pre translocation intermediate with EF-G bound to GDP and Pi (Structure III); tRNA fMet 7ssn 3 1539 3.2 RF00177,RF01959,RF01960 URS000080DDC0_83333 34903725 0003735 0005840 83333 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<.....<......>......>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<......>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<.<<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<........<<<....>>>.......>>>.....<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>.......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<.<.<<<......>>>.....>>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<...<<<.....>>>.>.....>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<.<.<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>.>.>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(.(..((.((..((((.(............).).)))))..))).)......(((......(((((((..((...(((((((.(.((.....(((.((....)).)))......)).).....(((....)))....((((((..(......))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..(((.......((((....))))......)))..((.(((((...(....(((.((((.......)))).))).....)....)))))....)).(.((([[[...(((((.....((.]]])).......)))))))).)..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((..(((((((....))))))).............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....))))))))..)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((.(.((((((....((((((.((.(..((....)).).))))))))...))))).).))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Pre translocation 70S ribosome with A/P* and P/E tRNA (Structure II-B); 16S rRNA 7ssn 1 2903 3.2 RF02540,RF02541 URS0000BC4674_83333 34903725 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugucgaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>...[.....<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))....].]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<.......>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<.........<.....<.....................>.........<<<......>>>.....>.....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><<<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>.>>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.......<<<<<..<<....>>...>>>>>.......>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<.<<...........<.......<<......<<.<<<<<....>>>>>.>>...>>.................>..>>.>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((.(((.(((...(((((......)))))[[......(((.....]])))...)))...))).)))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.(((......((...........)).......))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{...(.(...(...................)...........((......))...).).....)))..))))).))...........]]].)...))))))))))...)))))))((((((..........))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..(((((((((((....{{{...))))))((..((((....((.((((((((.((.....))))))))))...))...[))))...))(...((((....))))....))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.(....(..........(......(..........(((((....))))).......)................).)....).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(.(((((.....(....)....))))).).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((.......))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Pre translocation 70S ribosome with A/P* and P/E tRNA (Structure II-B); 23S rRNA 7ssn 2 120 3.2 RF00001 URS00008116C5_83333 34903725 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Pre translocation 70S ribosome with A/P* and P/E tRNA (Structure II-B); 5S rRNA 7ssn 5 77 3.2 RF00005 URS00002E063F_83333 34903725 0030533 0006412 83333 cggcgaguagcgcagcuugguagcgcaacugguuugggaccagugggucggagguucgaauccucucucgccgacca <<<<<<<..<<<<.........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... .((((((...(((......[..)))..(((((.......)))))......((((..]....)))).))))))..... Pre translocation 70S ribosome with A/P* and P/E tRNA (Structure II-B); tRNA Pro 7ssn 4 19 3.2 34903725 83333 aggagguaaaaaugccaag ................... ................... Pre translocation 70S ribosome with A/P* and P/E tRNA (Structure II-B); mRNA 7ssn 6 77 3.2 RF00005 URS000041AF00_83333 34903725 0030533 0006412 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(((((.......)))))))))))..... Pre translocation 70S ribosome with A/P* and P/E tRNA (Structure II-B); tRNA fMet 7sso 3 1539 3.2 RF00177,RF01959,RF01960 URS000080DDC0_83333 34903725 0003735 0005840 83333 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<..........>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<.<<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>.....<<<<<......<<<<<<<<<<.......>>>>>>>>.>>.......>>>>>.......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((.(.......)..))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..(......))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(..(.((((((((.......)))))))).)...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((.(....(((((((...((........))......)))))))....).......((....))..))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....))))))).............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....(((.((.((.(..((....)).).)))).)))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Pre translocation 70S ribosome with A/A and P/E tRNA (Structure II-A); 16S rRNA 7sso 1 2903 3.2 RF02540,RF02541 URS0000BC4674_83333 34903725 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugucgaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<.........>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<..........<....<...<<<.........>>>...>..........<<......>>......>.....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<..<<....>>...>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<...<....................<<.........<<<<<....>>>>>......>>.....................>...>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<.<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>...>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[......(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((((((.......)))).))...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[.....((((((.....(.....((..(((((..(((.....{.(((.(......(.............).............(((......)))..).)))...)))..))))).))...........]]].)...)))))).)))...)))))))((((((.(......).))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]]((((((((((.((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....((.((((((((.((.....))))))))))...))...[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...)).....)))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((((((((..(...............((.(............(.(.((......)).).)...................).))......)..))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....((.((((.((..]]]]..)))))).)).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Pre translocation 70S ribosome with A/A and P/E tRNA (Structure II-A); 23S rRNA 7sso 2 120 3.2 RF00001 URS00008116C5_83333 34903725 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa .<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>.. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((.(((((...))))).)).......))...)))))))))). Pre translocation 70S ribosome with A/A and P/E tRNA (Structure II-A); 5S rRNA 7sso 5 77 3.2 RF00005 URS00002E063F_83333 34903725 0030533 0006412 83333 cggcgaguagcgcagcuugguagcgcaacugguuugggaccagugggucggagguucgaauccucucucgccgacca <<<<<<<..<<<<.........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Pre translocation 70S ribosome with A/A and P/E tRNA (Structure II-A); tRNA Pro 7sso 4 19 3.2 34903725 83333 aggagguaaaaaugccaag ................... ................... Pre translocation 70S ribosome with A/A and P/E tRNA (Structure II-A); mRNA 7sso 6 77 3.2 RF00005 URS000041AF00_83333 34903725 0030533 0006412 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(.(((.......))).)))))))..... Pre translocation 70S ribosome with A/A and P/E tRNA (Structure II-A); tRNA fMet 7ssw 3 1539 3.8 RF00177,RF01959,RF01960 URS000080DDC0_83333 34903725 0003735 0005840 83333 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<...[((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<.<<<<..........>>>>..>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<..<<....<<<<<......>>>>>......>>.>.....<<<....>>.>...<<<<<...<......>.>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<...<<<<<<.........>>>>>>.>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<.<<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<...<<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>.....<<<<<........<<<<<<<<.......>>>>>>>>..........>>>>>.......<<<<<(((...<<<<<........))).........>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>..>>>>>>>>>>...<<<<<<.....<<<<<<<....<<<<<<<....<<<......>>>.......>>>>>>.>..........<<....>>.>>>>>>>....>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<.....>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).].<<<<.<<<<<<<.....<<<<...<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<.<<....>>.>>>>.............>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<..<<<<<<<...<....<<.....>>..>....>>>>>>>.....<<...........>>.........>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<......<<<..<<...<<<....>>>...>>....>>>......>>>>>>...........<<<<<<<........>>>>>>>...........>>>>.....<<<<<<...........>>>>>>...........>>>>>>>>>>.>........<<.<.<<<<.<<...<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>...>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((...................)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((........))))......)).).....(((....)))....((((((..(......))))))).)))))))..)).)))))))(((....((...((((((((.......)))))))).))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(.(((....)))..))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((....(((((((....(((((((...((........))......)))))))....).......((....)).))))))...))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((.((((.....)))).)))))))...((..]])).....)))))))))).(((.......(((....))).....)))...]]].](((((..((((((.....(((((..((((((((((......((........))........(.(((((((..(...((((((...(((((((....)))))))..............)))).))).((.((....((((((.(....(((((((((....)))...(((......)))...)))))).....((...(((((((...((..(((.....)))))....))))))).....((.(.......).))..........)).....).).)))...))..))))....))))))))..)).)))))))).....((((((......(((..((...(((....)))...))....)))......))))))......(....(.(.(((........))).).)....).....))))).....(.(((((.........))))).)...........)))))).))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((....((....))...))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Late translocation intermediate with EF-G dissociated (Structure VI); 16S rRNA 7ssw 1 2903 3.8 RF02540,RF02541 URS0000BC4674_83333 34903725 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugucgaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<......>..<<<<<<.....<<.....>>....>>>>>>..(((....<<......<<<<<<<<<<<<..<<<....<<<........>>>.((......<<<.....))>>>...>>>....>>>>>>>>>>>>...>>..........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<.......>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<........>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<.<....<.<...<<<.<<<<...<<.<<<.......>>>..>>...>>>>.>>>..>..>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<.........>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<..<......>..>>>>>....>>>>>><.<<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>>.>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<.<<<....>>>.>...>>>>>>...>>>...>>.>>........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<..<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<..<<....>>...>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>....................<<<<<.......>>>>>..........>>>>>..>>.>>>>>>>.....>>..>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<.<<<.<<.............<<<<<..<<.......<<<<<<<<....>>>>>>>>....>>............>>>>>....>>.>>>.>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<.<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>...>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<.)))..>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<.........>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. (..(((((......((((((((((.....(((..(((((((((((((......(((((..[..[[[..)).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((..(((((.((.(((...(((((......)))))[[......(((.....]])))...)))...)).)))))..)))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((((..)))))))..)))).[.(.(........).).((((((....(((((.(((((((..(((...((.....))...)))...((....))..((((.....)))).....))))))).)))))..((.(...((((((.....((((((.(((.((((...((((.(......).))))...)[)))...(((.(((((........))))))))..).)).)))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((.(((.......)))..))...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(.(((..(.(.....{.(((((..((..(.............)..))......(...((......)).).)))))...).)..))).).))...........]]].)...))))))))))...)))))))(((((..(......)..)))))....))))))(.(((((....((......((((((((....))))))))...))...)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]]((((((((((.((...((((....((((..(((..((((((((((((...{{{.).))))))((...(((....((.(..(((((.((.....)))))))..)...))...[)))....))(..(((((....)))))...))))))...)))...))))(..).....))))...)).....)))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((.(..(..(............(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...((((.((.....(((....))).......)).)))).}((((.(((..(((((((..(((........((.(...((....))....).))........))))))))..)))))(((((.........)))))........((..........(.(((.......))).)..)..)....))))...)).)))))))....))..).)))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((..(..(((((.(((((((.(...((...(.........((..(............((.(.((....)).).))...................)..)))...))...).)))))))...(((.((((((.....)))))))))....)))))..)...)))))..(((......[)))((((((..........])))))).[((....((((((...(((((.........))))).....((][.[[[))....))))))....((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..)))))))))......}......))))..))))))......(.((..(..(((((...((.......))...)))))....).))...)......((((.((.(((..(((((((((......))))))..))).(((((.....))))).....))).)..)...))).).....(((((.(....).).))))....))..)))))))))))[...(((.(((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((.(((}}}.))).))..)))))...)))).)))))....((....((((.....}.......))))....))..))))..]....))).)))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))..). Late translocation intermediate with EF-G dissociated (Structure VI); 23S rRNA 7ssw 2 120 3.8 RF00001 URS00008116C5_83333 34903725 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<......<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<...<.<..<<<<<<<...>>>>>>>....>.>.>>....>>>>>>>>>. .(((((((.(.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......(..(((((...)))))..).......))...).))))))).. Late translocation intermediate with EF-G dissociated (Structure VI); 5S rRNA 7ssw 6 77 3.8 RF00005 URS000041AF00_83333 34903725 0030533 0006412 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(((((.......)))))))))))..... Late translocation intermediate with EF-G dissociated (Structure VI); tRNA fMet 7ssw 4 20 3.8 34903725 83333 aggagguaaaaaugccaagu .................... .................... Late translocation intermediate with EF-G dissociated (Structure VI); mRNA 7ssw 5 77 3.8 RF00005 URS00002E063F_83333 34903725 0030533 0006412 83333 cggcgaguagcgcagcuugguagcgcaacugguuugggaccagugggucggagguucgaauccucucucgccgacca .<<<<<...<<<<.........>>>>.<<<<<<.....>>>>>>.....<..<<.......>.>.>.>>>>>..... ...((((..((((.........))))..(((((.....))))).......((((.......)))).))))....... Late translocation intermediate with EF-G dissociated (Structure VI); tRNA Pro 7st2 3 1539 2.9 RF00177,RF01959,RF01960 URS000080DDC0_83333 34903725 0003735 0005840 83333 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<.<<....>>.>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<......>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((((..........)))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((((.......)))))))).....)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....))))))).............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Post translocation, non-rotated 70S ribosome with EF-G dissociated (Structure VII); 16S rRNA 7st2 1 2903 2.9 RF02540,RF02541 URS0000BC4674_83333 34903725 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugucgaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<<.....>>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<......<.<<<<<.<<...<<<.........>>>...>>........<<<......>>>..>>>>>.>..>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<<.<<....>>..>>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<..................<<<...........<<.<<<<......>>>>.>>..................>>>.........>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[......(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((((..)))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((((((.......)))).))...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(.((.......)).)..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((.(......).))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((((.((((.(...............((((............(....((....))....)...................)))).....)..)))).))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Post translocation, non-rotated 70S ribosome with EF-G dissociated (Structure VII); 23S rRNA 7st2 2 120 2.9 RF00001 URS00008116C5_83333 34903725 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Post translocation, non-rotated 70S ribosome with EF-G dissociated (Structure VII); 5S rRNA 7st2 6 77 2.9 RF00005 URS000041AF00_83333 34903725 0030533 0006412 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).......(((.......)))..))))))..... Post translocation, non-rotated 70S ribosome with EF-G dissociated (Structure VII); tRNA fMet 7st2 4 19 2.9 34903725 83333 aggagguaaaaaugccaag ................... ................... Post translocation, non-rotated 70S ribosome with EF-G dissociated (Structure VII); mRNA 7st2 5 77 2.9 RF00005 URS00002E063F_83333 34903725 0030533 0006412 83333 cggcgaguagcgcagcuugguagcgcaacugguuugggaccagugggucggagguucgaauccucucucgccgacca <<<<<<<..<<<<.........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((......[..)))).(((((.......)))))......((((..]....)))).))))))).... Post translocation, non-rotated 70S ribosome with EF-G dissociated (Structure VII); tRNA Pro 7st6 3 1539 3.0 RF00177,RF01959,RF01960 URS000080DDC0_83333 34903725 0003735 0005840 83333 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<.<<<.<<....>>.>>>..>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<.<.........>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>..<<.<<<<<........<<<<<<<<.......>>>>>>>>..........>>>>>....>>.<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>.>..........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((..(............)...)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..(......))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((.(.........)))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..(((.......((((....))))......)))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...((((......((.]]]))........)))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((.(..((((((((((......((........))..........(((((((..(...(((((((..(((((((....))))))).............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..).))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Pre translocation, non-rotated 70S ribosome (Structure I); 16S rRNA 7st6 1 2903 3.0 RF02540,RF02541 URS0000BC4674_83333 34903725 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugucgaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<....<.<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>..>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<.<...<<<.<<<<...<<.<<.........>>..>>...>>>>.>>>..>..>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<.........>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><<<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>.>>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<.<.<<<...<<<....>>>...>>>..>>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>.>........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<..<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<<.<<....>>..>>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>.....>>..>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<..<<<<<<<<<<<................<<<<....<<......<<...<<......>.>..>>...>>..............>>>>.......>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>.....>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<.<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>...>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<.........>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((..((((((((.(((...(((((......)))))[[......(((.....]])))...)))...))))))))..)))...))))...)....(((((((...[.......)))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..))))...(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...).)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...((..((((...((.(((.......)))..))...))))..))..)).).....)))))).)))..)))))))).)...((((.((((........)))).))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((....(.........)....))).....(...((......)).).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((.(......).))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....)))))).......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(.(...(((....)))...).)..))))..(((((........)))))]](((((((((((((...((((....((((..(((..(((((((((((....{{{...))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...)........((((((((...((.........))...(((((((.....(((....))).......))))))).}((((.(((..(..((((..(((........(((((..((....))...)))))........)))))))....))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))..)..))).)))))))).))))))......).[..(((((......].)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((((.((((.................((.(............(....((....))....)...................).))........)))).))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))(.((...(((((((...(((((.........))))).....((.[.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((...((((((...((.......))...))))))....))).).)......((((.((.(((..(((((((((......))))))..))).(((((.....))))).....))).)..)...))).).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(.(((((.....(....)....))))).).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Pre translocation, non-rotated 70S ribosome (Structure I); 23S rRNA 7st6 2 120 3.0 RF00001 URS00008116C5_83333 34903725 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<......<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>....>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Pre translocation, non-rotated 70S ribosome (Structure I); 5S rRNA 7st6 5 77 3.0 RF00005 URS00002E063F_83333 34903725 0030533 0006412 83333 cggcgaguagcgcagcuugguagcgcaacugguuugggaccagugggucggagguucgaauccucucucgccgacca <<<<<<<..<<<<.........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))).... Pre translocation, non-rotated 70S ribosome (Structure I); tRNA Pro 7st6 7 77 3.0 RF00005 URS000041AF00_83333 34903725 0030533 0006412 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<...<<<<.........>>>>.<<<.<........>>>>.....<<<<<.......>>>>>.>>>>>..... .(((((...((((......[..))))..((.(........))).............]..........)))))..... Pre translocation, non-rotated 70S ribosome (Structure I); tRNA fMet 7st6 4 18 3.0 34903725 83333 aggagguaaaaaugccaa .................. .................. Pre translocation, non-rotated 70S ribosome (Structure I); mRNA 7st6 6 77 3.0 RF00005 URS000041AF00_83333 34903725 0030533 0006412 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Pre translocation, non-rotated 70S ribosome (Structure I); tRNA fMet 7st7 1 2903 3.2 RF02540,RF02541 URS0000BC4674_83333 34903725 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugucgaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<........>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<<.....>>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<...<........<<<<<..<<...<<.........>>...>>.........<<........>>..>>>>>....>...>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<......>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<.<.<<<...<<<....>>>...>>>..>>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>.>........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<..<<....>>...>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<..............<..<<...<<......<<...<<<....>>.>..>>...>>.............>>..>.....>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((.((((((.((.(((...(((((......)))))[[......(((.....]])))...)))...)).)))))).)))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...).)))...(((.(((((........))))))))..).))))))))).(.((.......))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...((..((((...((.(((.......)))..))...))))..))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..((.........(..(...(....(.........)....)............(......)....)..).....))..))))).))...........]]].)...))))))))))...)))))))((((..............))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..(((((.(((((....{{{...))))).((...(((...((((((((((((.((.....))))))))))..))))..[)))....))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((...((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(.(((.........))).)........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.((..(((((.((((((.((...(.((...............(..............(..((....))..).....................)......)).)...)).))))))...(((.((((((.....)))))))))....)))))..))..)))))..(((......[)))((((((..........]))))))(.((...(((((((...(((((.........))))).....((.[.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....((.((((.((..]]]]..)))))).)).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Pre translocation intermediate stalled with viomycin and bound with EF-G in a GDP and Pi state (Structure III-vio); 23S rRNA 7st7 2 120 3.2 RF00001 URS00008116C5_83333 34903725 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa .<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.....<.<<<<<<<<...>>>>>>>>...>...>>...>>>>>>>>>.. ..((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((.(((((...))))).)).......))...))))))))... Pre translocation intermediate stalled with viomycin and bound with EF-G in a GDP and Pi state (Structure III-vio); 5S rRNA 7st7 3 1539 3.2 RF00177,RF01959,RF01960 URS000080DDC0_83333 34903725 0003735 0005840 83333 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<..........>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<.<....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>.....<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>.......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<.....>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<.<<.<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>..>>>>..>>.>>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((..(............)...)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((.(....).))))......)).).....(((....)))....((((((..(......))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((((.......)))))))).....)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.(((((((((.......((((((.....)))))).....)))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...((((((....)))))).....(....)...))))).))).((.((....((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...))..))))....)))))))...)).)))))))).(...(.(((((.....(((..((...(((....)))...))....))).....))))).)......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((......((.(((((....((((((.((((..((....)).))))))))))...))))).))......))).))))..).))...)..)..(((((((((....)))))))))}........... Pre translocation intermediate stalled with viomycin and bound with EF-G in a GDP and Pi state (Structure III-vio); 16S rRNA 7st7 4 19 3.2 34903725 83333 aggagguaaaaaugccaag ................... ................... Pre translocation intermediate stalled with viomycin and bound with EF-G in a GDP and Pi state (Structure III-vio); mRNA 7st7 6 77 3.2 RF00005 URS000041AF00_83333 34903725 0030533 0006412 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(((((.......)))))))))))..... Pre translocation intermediate stalled with viomycin and bound with EF-G in a GDP and Pi state (Structure III-vio); tRNA fMet 7st7 5 76 3.2 RF00005 URS0000EC976D_83333 34903725 0030533 0006412 83333 cggcgaguagcgcagcuugguagcgcaacugguuugggaccagugggucggagguucgaauccucucucgccgacc <<<<<<<..<<<<.........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>... (((((((..((((......[..)))).(((((.......)))))......((((..]....)))).)))))))... Pre translocation intermediate stalled with viomycin and bound with EF-G in a GDP and Pi state (Structure III-vio); tRNA Pro 7suk L0 488 3.99 URS000007769E_4932 35650250,35650250 4932 gaagacaagugcuugucguucguuaauggccucgucaaacgguggagagagucgcuaggugaucgucagaucugccuagucucuauacagcguguuuaauugacauggguugaugcguauugagagauacaauuugggaagaaauucccagaguguguuucuuuugcguuuaaccugaacagucucaucgugggcaucuugcgauuccauuggugagcagcgaaggauuugguggauuacuagcuaauagcaaucuauuucaaagaauucaaacuugggggaaugccuuguugaauauucuucaaguguaaccuccucucaaaucagcgauaucaaacguaccccgugaaacaccgggguaucuguuugguggaaccugauuagaggaaacucaaagagugcuaugguauggugacggagugcgcuggucaagaguguaaaagcuuuuugaacagagagcauuuccggcagcagagauuucagcuguu <<<<<<.<....>.>>>.>>>............<<<<<<<<.<<...<<<<..<<<<<<.<<<<....>>>>..>>>>>>>>>>...>>.>>>......>>>>>..<<<<<...<<<<<..<<<<<.<<<<.<<<<<<<<....>>>>>>>.>>>>>.>>>>>>.>>>>..>>>>>.......<<<<<<<<<<<...........>>>>>.>>>>>>.........................<<<...>>>.........................<<<<<...<<<<<<..<.....>...>>>>.>>..>>>>>.....<<<<<<...<<<<<<<<<<<<<<<<........>>>>>>>.>.>>>>>>>>....>>>>>>.................................<<<<<<<<.<<<.<<<<<<<........>>>.>>>>.>>>...>>>.>>>>><<<<<.<.....>..>>>>>. ((.((...(..)...))..))............((((((((.((...((((..((((((.((((....))))..))))))))))...)).)))......)))))..(((((...(((....(((.(..(((..((((((......))))).).))).)..)))...)))..))))).....(.(.((((((((((.....)....))))).)))).))........................(((...))).........................(((((..(((((((............)))).)).)))))).....((((((....((((((((((((((((.....).))))))).).))))))).....)))))).................................((((((((.(((.((((((..........)).)))).)))...)))).))))(((((.((....)).))))). Structure of Bfr2-Lcp5 Complex Observed in the Small Subunit Processome Isolated from R2TP-depleted Yeast Cells; 5' ETS 7suk L2 169 3.99 RF01846 URS0000B21E09_4932 35650250,35650250 0006396 0005730 4932 gucgacguacuucauaggaucauuucuauaggaaucgucacucuuugacucuucaaaagagccacugaauccaacuugguugaugagucccauaaccuuuguacccagugagaaaccguauggcgcgaugaucuacccauggguggguacaaauggcagucugacaagu .........................................................................<<<<<......<..........<<<<<<<<<<...........<....>............<<<....>>>.>>>>>>>>.>>....>...>>>>> .........................................................................(((((......(..........((((((...(..(...(....(....)...)......).(((....))).)...)))).))....)...))))) Structure of Bfr2-Lcp5 Complex Observed in the Small Subunit Processome Isolated from R2TP-depleted Yeast Cells; U3 snoRNA 7suk 8 1192 3.99 RF01960,RF01959,RF00177 URS0000BC4691_4932 35650250,35650250 0003735 0005840 4932 agauaguuaucugguugauccugccaguagucauaugcuugucucagccaugcagcucauuaaaucaguuaucguuuauuugauagucaugguauaacugugguaauucuagagcuaaaaucucgacccuuuggaagagauguauuuauuagaucaaugucuucggacucuuugaugaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaagggcaggcuuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuagcucguaguugaacuauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaagacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcucaacacggggaaacucaccagguccagacacaauauuugugggugguggugcaugugaugcccuuguucuggcgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaaaacuccgucggggaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccucucagagcggagauuuggacaaacuuggucauuuagaggaacuaauuccguaggugaaccugcggaa ................................<<<<<<.....<..<<<.<<<..<<<.......<<<..<<..<.....<<<..............<<..<<.....>>..>>............<<....>>...........<<<<...........<....>............>>>>...........<<...<<.....>>..>>......>>>....>>>..>>>...<....<<<....<<<<<<<<.......>>>>>>>>>>>......>......<<<...............>>>.>>>.<<.<<<..........>>>.>>.<.<<....>>.>.>>>>>>..<<<....<<<.....>>>..>>>.......>.......<<<<<<<.<<<<<....>>>>>.>>>.>>>>......<<..<...........>..>>........<<<<<<<.......<<<....>>>..................>>>>>>>.>>>>>>......<<..................<..<<<.<<...<<<.......<<<<.......<<<......>>>..........>>>>..........<<<....>>>...>>>..>>.>>>...>.........>>..........<<........<...............>.....>>.......<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>................................................<<.........>>.....<<<<<<<<<<<<..<<.<<<<<<..<<<.<<<<....................<<<<<......<<<<.....>>>>......<<<.........>>>.....>>>>>>>>>.>>>.....<<<<<<<............<<<..<<<<....>>>>..>>>.....>>>>>>>............>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>............>>>>>..<<<<.<<....<<<<<<<<.<<<....<<......<<<<<<<.<<<<.<.<......>>.>>>>.>>>>>>>.....>>....>>>.>>>>>>>>...>>.>>>>..<<<<<<<<....>>>>>>>>. ................................((((((.....(..(((.(((..(((.......(((..((....(...(((..............((..((.....))..)).......(....((....))..)......(..(.(...........(....)............).)..).........(....(((..).))...)......)))....)))..)))........(((....((((((((.......)))))))))))..............((...(.........).))..))).((.(((..........))).)).(.(.......)).))))))..((.....(((.....)))...)).......).......(((((((((((((....))))))))).))))....(.((..(...........)..))......)..(((((((......(((....)))...............)..))))))..))))))....(.((..................(..(.(.((...(((.......(((........((........))...........)))...........((....))....)))..)).).)...).........)).).........(....(...(...............)...).)........(((..(((((..(.(((........))))..)))))..)))................................................((.........)).....((((((((((((..((..(((((..(((..(((....................(((((.(....((((.....))))....(.((.((....).).)))..).))))))))..))).(...(((((((............(((..((((....))))..))).....))))))).(....)..)..))))).....(.((((((.......)))))).)......))...)))))))............)))))..((((..(..(..(((((((.(((..(.((..(...(((((((.(.(..(..(....)..)..)).)))))))..)..)).)..))).))))))).)..)..)))).(((((.(((....))).))))) Structure of Bfr2-Lcp5 Complex Observed in the Small Subunit Processome Isolated from R2TP-depleted Yeast Cells; 18S pre-rRNA 7swf B 17 3.79 URS000036142B_32644 35801914 32644 uggagugugacaauggu ................. ................. Cryo-EM structure of Arabidopsis Ago10-guide-target RNA complex in a central duplex conformation; RNA (5'-R(P*UP*GP*GP*AP*GP*UP*GP*UP*GP*AP*CP*AP*AP*UP*GP*GP*U)-3') 7swf D 17 3.79 URS0000E60B76_32644 35801914 32644 ccauugucacacuccaa ................. ................. Cryo-EM structure of Arabidopsis Ago10-guide-target RNA complex in a central duplex conformation; RNA (5'-R(P*CP*CP*AP*UP*UP*GP*UP*CP*AP*CP*AP*CP*UP*CP*CP*AP*A)-3') 7swq B 21 3.79 URS000036142B_32630 37127820 32630 uggagugugacaaugguguuu ..................... ..................... Cryo-EM structure of Arabidopsis Ago10-guide-target RNA complex in a bent duplex conformation; RNA (5'-R(P*UP*GP*GP*AP*GP*UP*GP*UP*GP*AP*CP*AP*AP*UP*GP*GP*UP*GP*UP*UP*U)-3') 7swq D 14 3.79 URS0000E60B76_32630 37127820 32630 ccauuacacuccaa .............. .............. Cryo-EM structure of Arabidopsis Ago10-guide-target RNA complex in a bent duplex conformation; RNA (5'-R(P*CP*CP*AP*UP*UP*GP*UP*CP*AP*CP*AP*CP*UP*CP*CP*AP*AP*A)-3') 7syg 2 1697 4.3 RF01960,RF01959,RF00177 URS00023359E5_9986 0003735 0005840 9986 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucgacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgcccggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcggccguccccugcucggcgccggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauuuggcgaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgaccccggucggcguaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggugcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.[[((((>>>>><<<.<<<<<<...<.<<.........<<<.<<<...<....<<....<<..........>>...>>.>.......<<........<<<.<....<<....<<<..........<<.....<<..<.......>..>>......>>.........<<<<...<<<<<<....>>>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<...>>>>>>>....>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<...<<<<.....>>>.>>>>......>>.>.....<<<<<<<<<.<<<....>>>..>>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<.....<<.<.<..>.>.>>..<<<<<..<<..>>.>>>.>>..<<<.<<.<.......<<...<.......>.<<<<.>>>>...>>......>.>>...>>>........<.<<.<<<<<<<...............>>>>>>>.>>.>....>>....<<<<<<......<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>.....>>>.>>>...>>>...>>.>...<<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..>.......<<<.<<.<<<..<.<<<<<<.<<<........>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]].<...<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<......<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<.....<<<<<.....<<<.<<<<......>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<..>>>>.>>>>>>>>..>>>>..>.....<<<<<.....>>>>>........>>>.....>>.>>>.......>>>>>.......>>>>>...>>.>>>>.>>>.....<<.<<<................<<<.<<<<....>>>>.>>>..............>>>.>>..........<.<<<<<..........>>>>>>..........>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>..>.......<..<<.<..<<<<.<<....<<<<<<<<.<<<...<<<.<<...<<<<<..<<<<<<<<..>>>>>>>>....>>>>>...>>.>>>...>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((....[[[[.))))(((.((((((...(.((..((.....(((.(((........((....((..........))...))[........(((.......(((...(..((....(((.....((...((.....((..((.....))..))......))......)).((((...(((((......)))))...)))).(..(((((...(......)..)))))......)..(.((((.(((...))))))))...)))...)))...))).(((....(((.....((((((.........)))))).)))......)))...(((.(((......)))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).).....(((((((((.(((....)))..)))))).)).)...(.((..(...........)..))......)...(((([[......((((.....((..]])).......)))).))))...)))))).)))..[......(.([[...(.(.((...(((..(.....((...(..)...))..((((...((()))..)).))...((.((.(.......((..((.......)).((...))....))......).))...)).........(.(..(((((((...............)))))))..).)....)....(((..(.(.(...((((..(((.(((((((....((........)).......))))))).))).......((....))...))))..)..))...))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((..((..(.((((((.((((......)))))))))).)..))....((..]]))...))...].))))).).(((......((((....))))....)))..]]]]........((((((...((..(((((..(((.((((((.....(((........)).........)(((((..(...((((((....(..((..((........))..))....)))))))...((.((......((((.(......(.(((((....)))..(.((......)))...)).)......(((...(...(.((..((((((((((.(..).)).))))))))..)).)..).....(((((.....)))))........))).....)).)))........)))).....).)))))...)).)))).))).(...((.(((........(.......((...(((....)))...))....).........))).))......(.....(((((..........))))).....)..)..))))).....(.(((..(.......)..))).)......))....))))))..........(..((.(..(((..((..(..(((((((.(((..(.((.((...((((((.((((.(((..))).))).).).)))))...)).)).)..))).))))))).)..))..)))...).))...).....((((((((......))))))))}........ Structure of the HCV IRES binding to the 40S ribosomal subunit, closed conformation. Structure 1(delta dII); 18S rRNA 7syg z 162 4.3 RF00061 URS00023359E0_11104 0043022 11104 cccccccucccgggagagccauaguggucugcggaaccggugaguacaccggaaugauuugggcgugcccccgcaagacugcuagccgaguaguguugggucgcgaaaggccuugugguacugccugauagggugcuugcgagugccccgggaggucucgua .....<<<<<<<<<<<.<<<.<<<<<<<<<<<<<..<<<<<<....>>>>>><<<.>>>.<<<<..>>>>>>>>.>>>>>>>>><<<.....<<........>>....>>>.....>>>.>><<<......>>><<...((((.>>>>>>>>>>>.)))).. .....(((((((((((..((.(((.((((((.((..((((((....))))))(((.))).((((..)))))).).))))).)))(((.....((........))....)))(..).)).[))..((..]..)).((...[[[[.))))))))))).]]]].. Structure of the HCV IRES binding to the 40S ribosomal subunit, closed conformation. Structure 1(delta dII); HCV IRES 7syh 2 1697 4.6 RF01960,RF01959,RF00177 URS00023359E5_9986 0003735 0005840 9986 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucgacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgcccggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcggccguccccugcucggcgccggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauuuggcgaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgaccccggucggcguaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggugcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<..[[((((.>>>><<<.<<<<<<...<.<<.........<<<.<<<...<....<<....<<..........>>...>>.>.......<<........<<<.<....<<....<<<..........<<.....<<.<<.......>>.>>......>>.........<<<<...<<<<<<....>>>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<<.>>>>>>>>....>>>...>>..>.>>>.<<<....<<<.....<<<<<<.........>>>>>>.>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<<..>>>.>...>>>>>>.........<<<...<<<<.....>>>.>>>>......>>.>.....<<<<<<<<<.<........>..>>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<.....<<.<<<..>>>.>>.<<<<<...<<..>>..>>.>>>.<<<<<<.<.......<<...<.......>.<<<<.>>>>...>>......>.>>>..>>>........<.<<.<<<<<<<...............>>>>>>>.>>.>....>>....<<<<<<......<<<<..<<<.<<<<<<<<...<<<......>>>......>>>>>>>>.>>>.......<<....>>...>>>>.....>>>.>>>...>>>...>>.>....<<<<<<....<...<<<<.........>>>>...>.>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<........>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<......>>>....>>>..)))).]].....<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<......<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<.....<<<<<.....<<<.<<<<......>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<..>>>>.>>>>>>>>..>>>>..>.....<<<<<.....>>>>>........>>>.....>>.>>>.......>>>>>.......>>>>>...>>.>>>>.>>>.....<<.<<<................<<<.<<<<....>>>>.>>>..............>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>..........<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<..<<<<<<<....>>>>>>>....>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((....[[[..))))(((.((((((...(.((...(.....(((.(((........((....((..........))...))[.........((.......(((...(..(.....(((.....((...((.....((..(.......)..))......))......)).((((...(((((......)))))...)))).(..(((((...(......)..)))))......)..(.((...((.(..)))..)))...)))....))...))).(((....(((.....((((((.........)))))).)))......)))...(((.((((....))))....)))))..((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).....)).)......(((((((..(........)...))))).)).....(.(...(...........)...)......)...(((.[[......((((.....((..]])).......))))..)))...)))))).)))..[......(.([[...(.(.((....((.((.....((...(())...))..((((...((()))..)).))...((..(.(.......((..((.......)).((...))....))......).)....)).........(.(..(((((((...............)))))))..).)....))....((..(.(.....((((..(((.((((((((...((........))......)))))))).))).......((....))...)))).....))...))...))....)).)....((.((.....(...((((.........))))...)..)).))......{...(((.((..((..(.((((((.((.(......).)))))))).)..))....((..]]))...))...].))))).).(((......((((....))))....)))...]]]...(....(((((((..((..(((.(..(((.((((((......((........))..........((((...(...(((((.....(..((..((........))..))....).)))))...((..((.....((((.(......(.((..(....)....(.((......)))...)).)......(((...(...(.((..((((((((((((..)))).))))))))..)).)..).....(((((.....)))))........))).....)).))).......)).)).....)..))))...)).)))).))).(...((.(((........(.......(((..(((....)))..)))....).........))).))......(.....(((((..........))))).....)..)..).))).....(..((.((.......)).))..)......))...))))))).....)....(..((.(..((((.((..(..(((((((.(((..((((.((...((((((.((((.(.(..).).))).).).)))))...)).))))..))).))))))).)..)).))))...).))...).....((((((((......))))))))}........ Structure of the HCV IRES binding to the 40S ribosomal subunit, closed conformation. Structure 2(delta dII); 18S rRNA 7syh z 162 4.6 RF00061 URS00023359E0_11104 0043022 11104 cccccccucccgggagagccauaguggucugcggaaccggugaguacaccggaaugauuugggcgugcccccgcaagacugcuagccgaguaguguugggucgcgaaaggccuugugguacugccugauagggugcuugcgagugccccgggaggucucgua .....<<<<<<<<<<<.<<<.<<<<<<<<<<<<...<<<<<<....>>>>>><<<.>>>.<<<<..>>>>.>>>.>>>>>>>>><<<.....<<........>>....>>>.....>>>.>>............<<..(((((.>>>>>>>>>>>.))))). .....(((((((((((..(..(((..((((.(.(..((((((....))))))(((.))).((((..))))).)..))))..)))(((.....((........))....)))(..)..)..))............((...[[[[.))))))))))).]]]].. Structure of the HCV IRES binding to the 40S ribosomal subunit, closed conformation. Structure 2(delta dII); HCV IRES 7syi 2 1697 4.5 RF01960,RF01959,RF00177 URS00023359E5_9986 35822879 0003735 0005840 9986 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucgacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgcccggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcggccguccccugcucggcgccggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauuuggcgaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgaccccggucggcguaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggugcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.[[((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<....<<....<<<<<........<<.....<<..<.......>..>>......>>.........<<<<...<<<<<<....>>>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<<.>>>>>>>>.>>.>>>...>>..>.>>>.<<<....<<<.....<<<<<<.........>>>>>>.>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>...<<<..>>>.....>>>>>>.........<<<...<<<<.....>>>.>>>>..>...>>.>.....<<<.<<<<<.<<......>>..>>>>>..>>>......<...<...........>...>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<....<<<.<<<..>>>.>>>.<<<<...<<..>>..>>.>>..<<<<<<.<.......<<...<.......>.<<<<.>>>>...>>......>.>>>..>>>........<.<<.<<<<<<<...............>>>>>>>.>>.>....>>....<<<<<<......<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>.....>>>.>>>...>>>...>>.>....<<<<<<....<...<<<<.<.....>.>>>>...>.>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<........>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]].<...<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<......<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<..<<<<<.....<<<.<<<<......>>...<<<......>>>...>>.>>>....<<<...<...<.<<..<<<<<<<<<<<<..>>>>.>>>>>>>>..>>.>..>.....<<<<<.....>>>>>........>>>.....>>.>>>......>>>>>>.......>>>>>...>>.>>>>.>>>.....<<.<<<................<<<.<<<<....>>>>.>>>..............>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>..>.......<...<.<..<<<<.<<....<<<<<<<<.<<<...<<<.<<...<<<<<..<<<<.<<<..>>>.>>>>....>>>>>...>>.>>>...>>>.>>>>>>>>...>>.>>>>...>.>....>.....<<<<<<<<<....>>>>>>>>>......... ...((((....[[[..)))).((.((((((...(.((..((.....(((.(((........((....((..........))...))[........(((.......(((...(..(.....(((.....((...((.....((..((.....))..))......))......)).((((...((((((....))))))...))))....(((((...(......)..))))).........(.((((.((.(..))))))))...)))....))...))).((.....(((......(((((.........)))))..))).......))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).).....(((.(.((..(........)...)).)..)).)...(.(...(...........)...)......)..((((([[......((((.....((..]])).......)))).)))))..)))))).))...[......(.([[...(.(.((...(((.((....(((...(..)...))).((((...((()))..)).))...((.((.(.......((..((.......)).((...))....))......).))...)).........(.(..(.((((.................)))).)..).)....))...(((..(.(.(...((((..(((.(((((((....((........)).......))))))).))).......((....))...))))..)..))...))..))))...)).)....(((((.....(...((((.........))))...)..)))))......{...(((.((..((..(.((((((.((((......)))))))))).)..))....((..]]))...))...].))))).).(((......((((....))))....)))...]]]........((.(((...((..(((.(..(((.((((((......((........))..........((.(...(...((((((...........((........)).........))))))....(.((......(((..(....(((.((((......))..(.((......)))...)).)))....(((...(.....((..((((((((((.(..).)).))))))))..))....).....(((((.....)))))........))).....)..)))........)))......)..).))...)).)))).))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....(((((..........))))).....)..)..).))).....((.((..(.......)..)).))......))....))).))..........(...(.(..(((...(..(.((((((((.(((..((((.((...((((((.((((.(.(..).).))).).).)))))...)).))))..))).)))))))))..)...)))...).)....).....((((((((......))))))))}........ Structure of the HCV IRES binding to the 40S ribosomal subunit, closed conformation. Structure 3(delta dII); 18S rRNA 7syi z 162 4.5 RF00061 URS00023359E0_11103 35822879 0043022 11103 cccccccucccgggagagccauaguggucugcggaaccggugaguacaccggaaugauuugggcgugcccccgcaagacugcuagccgaguaguguugggucgcgaaaggccuugugguacugccugauagggugcuugcgagugccccgggaggucucgua .....<<<<<<<<<<<.<<<<<<<<<<<<<<<<<..<<<<<<....>>>>>><<...>>.<<<<..>>>>>>>>.>>>>>>>>><<<.....<<........>>....>>>....>>>>.>><<<......>>><<...((((.>>>>>>>>>>>.)))).. .....(((((((((.(..((.(((..((((((((..((((((....))))))(((.))).((((..)))))))).))))..)))(((.....(..........)....)))(..).)).[)..((...]..)).((...[[[[.))))))))))).]]]].. Structure of the HCV IRES binding to the 40S ribosomal subunit, closed conformation. Structure 3(delta dII); HCV IRES 7syj 2 1697 4.8 RF01960,RF01959,RF00177 URS00023359E5_9986 35822879 0003735 0005840 9986 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucgacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgcccggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcggccguccccugcucggcgccggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauuuggcgaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgaccccggucggcguaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggugcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<...(((.>>>>><<<.<<<<<<...<.<<..<......<<<.<<<........<<....<<..........>>...>>.........<<........<<<.<....<<....<<<..........<<.....<<.<<.......>>.>>......>>.........<<<<...<<<<<......>>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<..<<<...>>>.>>>....>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>...<<<..>>>.....>>>>>>.........<<<....<<<.....>>>..>>>..>...>>.>.....<<<<<<<<<..<<....>>...>>>>>>.>>.>.....<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<.....<<.<.<..>.>.>>..<<<<<<.<<..>>>>>>.>>..<<<.<<.<.......<<...<.......>.<<<<.>>>>...>>......>.>>...>>>........<.<<.<<<<<<<...............>>>>>>>.>>.>....>>....<<<<<<......<<<<..<<..<<<<<<<<...<<........>>......>>>>>>>>..>>.......<<....>>...>>>>.....>>>.>>>...>>>...>>.>....<<<<<<....<...<<<<.<.....>.>>>>...>.>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<........>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>...)))........<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<......<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<.....<<<<<.....<<<.<<<<......>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<..>>>>.>>>>>>>>..>>>>..>.....<<<<<.....>>>>>........>>>.....>>.>>>.......>>>>>.......>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>..............<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<..<<<<.<<....>>.>>>>....>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>..........<<<<<<<<<....>>>>>>>>>......... ...((((....[[[..)))).((.((((((...(.((..((.....(((.(((........((....((..........))...))[.........((.......(((.(.(..((....(((.....((...((.....((..((.....))..))......))......)).((((...(((((.(...))))))...))))....(((((...(......)..))))).........(.((...(((...)))..)))...)))...))).).))).(((....(((.....((((((.........)))))).)))......)))...(((.(((......)))....)))))..((.(((..........))).))...((....)).....)))))).).....(.(((...((((.]...))).))))).)...)).).....(((((.(((.(........)..))).)).)).)...(.....(...........)..........)...(((([[......((((.....((..]])).......)))).))))...)))))).))...[......(.([[...(.(.((...(((.((.....((...(..)...))..(((((..((())).))).))...((.((.(.......((..(.........).((...))....))......).).)..)).........(.(..((((((.................))))))..).)....))...(((..(.(.....((((..(((.((((((((...((........))......)))))))).))).......((....))...)))).....))...))..))))...)).)....(((((.....(...((((.........))))...)..)))))......{...(((.((.(((....((((((.((.(......).))))))))....)))...((..]]))...))...].))))).).(.(......((((....))))....).)...]]]..(.....(((((((..((..(((((..(((.((((((.......(........)...........((((...(...(((((........((..((........))..))......)))))...((.(((.....((((.(......(.(((.(.....))..(.((......)))...)).)......(((.(.(...(.((..((((((((((.(..).)).))))))))..)).)..).....(((((.....))))).......)))).....)).))).......))))).....)..))))...)).)))).))).(...((.(((........(.......(((..(((....)))..)))....).........))).))......(.....(((((..........))))).....)..)..))))).....(..((..(.......)..))..)......))...))))))).....)....(.....(..(((...(..(..(((((((.(((..(.((.((...((((((.((((..((..))..))).).).)))))...)).)).)..))).))))))).)..)...)))...)......).....((((((((......))))))))}........ Structure of the HCV IRES binding to the 40S ribosomal subunit, closed conformation. Structure 4(delta dII); 18S rRNA 7syj z 162 4.8 RF00061 URS00023359E0_2847144 35822879 0043022 2847144 cccccccucccgggagagccauaguggucugcggaaccggugaguacaccggaaugauuugggcgugcccccgcaagacugcuagccgaguaguguugggucgcgaaaggccuugugguacugccugauagggugcuugcgagugccccgggaggucucgua .....<<<<<<<<<<<.<<<.<<<<<<<<<<<<<..<<<<<<....>>>>>><<...>>.<<<<..>>>>>>>>>.>>>>>>>><<<.....<<........>>....>>>.....>>>.>>............<<..(((((.>>>>>>>>>>>.))))). .....(((((((((((..((.(((..((((((((..((((((....))))))(((.))).((((..)))))))).))))..)))(((.....(..........)....)))(..).)).[))..(...]...).((...[[[[.))))))))))).]]]].. Structure of the HCV IRES binding to the 40S ribosomal subunit, closed conformation. Structure 4(delta dII); HCV IRES 7syk 2 1697 4.2 RF01960,RF01959,RF00177 URS00023359E5_9986 35822879 0003735 0005840 9986 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucgacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgcccggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcggccguccccugcucggcgccggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauuuggcgaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgaccccggucggcguaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggugcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.[[((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<...<....<<....<<..........>>...>>.>.......<<........<<<.<....<<....<<<<.........<<.....<<.<<.......>>.>>......>>.........<<<<...<<<<<<....>>>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<...>>>>>>>..>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<<..>>>.>...>>>>>>.........<<<....<<<.....>>>..>>>..>...>>.>.....<<<<<<<<<.<........>..>>>>>>.>>>......<<..<...........>..>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<.....<<.<<<..>>>.>>..<<<<<..<<..>>.>>>.>>..<<<<<<.<.......<<...<.......>.<<<<.>>>>...>>......>.>>>..>>>........<.<<.<<<<<<<...............>>>>>>>.>>.>....>>....<<<<<<......<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>.....>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<........>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<......>>>....>>>..)))).]].<...<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<......<<<<<<.......<<.<<<........>>>.>>.....>>>>>>.<.<<.<<<.....<<<.......<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<..>>>>.>>>>>>>>..>>>>..>.....<<<<<.....>>>>>........>>>........>>>.......>>>>>>......>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<...<.<<<<<..........>>>>>>....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>..>.......<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<..<<<<<<<<..>>>>>>>>....>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[[[[[..))))(((.((((((...(.((..((.....(((.(((..(.....((....((..........))...))[.)......(((.......(((.(.(..(.....(((.....((...((.....((..((.....))..))......))......)).((((...((((((....))))))...)))).(..(((((...(......)..)))))......)..(.((((.(((...))))))))...)))....)).).))).(((....(((.....((((((.........)))))).)))......)))...(((.(((......)))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).)......((((((((.(.(....).)..)))))).)).....(.((..(...........)..))......)..((((([[......((((.....((..]])).......)))).)))))..)))))).)))..[......(.([[...(.(.((...(((..(....(((.(.(())..)))).(((((..((())).))).))..(((.((.(.......((..((.......)).((...))....))......).).)..)))........(.((.((((((.................)))))).)).)....)....(((..(.(.(...((((..((..((((((((...((........))......))))))))..)).......((....))...))))..)..))...))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((..((..(.((((((.((((......)))))))))).)..))....((..]]))...))...].))))).).(((......((((....))))....)))...]]].]].....(((((((..((..(((((..(((.((((((......((........))..........(((((..(...((((((.......((..((........))..)).....))))))....(..((......(((.(....(((.(((((....)))..(.((......)))...)).)))....(((...(...((((..((((.(((((.(..).)).))).))))..))))..).....(((((.....)))))........))).....)).))........)).)......).)))))...)).)))).))).(...((.(((........(.......(((..(((....)))..)))....).........))).))......(.....(((((..........))))).....)..)..))))).....(..((.((.......)).))..)......))...)))))))..........(..((.(..((((.((..(..(((((((.(((..((((.((...((((((.((((.(((..))).))).).).)))))...)).))))..))).))))))).)..)).))))...).))...).....((((((((......))))))))}........ Structure of the HCV IRES binding to the 40S ribosomal subunit, closed conformation. Structure 5(delta dII); 18S rRNA 7syk z 162 4.2 RF00061 URS00023359E0_2847144 35822879 0043022 2847144 cccccccucccgggagagccauaguggucugcggaaccggugaguacaccggaaugauuugggcgugcccccgcaagacugcuagccgaguaguguugggucgcgaaaggccuugugguacugccugauagggugcuugcgagugccccgggaggucucgua .....<<<<<<<<<<<.<<<<<<<<<<<<<<<<<..<<<<<<....>>>>>><<<.>>>.<<<<..>>>>>>>>.>>>>>>>>><<<.....<<........>>....>>>....>>>>.>><<<......>>><<..(((((.>>>>>>>>>>>.))))). .....(((((((((((..((((((..((((((((..((((((....))))))(((.))).((((..)))))))).))))..)))(((.....(..........)....)))(..)))).[))((((..].))))((...[[[[.))))))))))).]]]].. Structure of the HCV IRES binding to the 40S ribosomal subunit, closed conformation. Structure 5(delta dII); HCV IRES 7syl 2 1697 4.5 RF01960,RF01959,RF00177 URS00023359E5_9986 35822879 0003735 0005840 9986 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucgacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgcccggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcggccguccccugcucggcgccggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauuuggcgaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgaccccggucggcguaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggugcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<.........<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<....<<....<<<..........<<.....<<.<<.......>>.>>......>>.........<<<<...<<<<<<....>>>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<<.>>>>>>>>....>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>...<<<..>>>.....>>>>>>.........<<<....<<<.....>>>..>>>......>>.>.....<<<.<<<<<.<<<....>>>..>>>>>..>>>......<...<...........>...>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<....<<<.<.<..>.>.>>>.<<<<...<<..>>..>>.>>..<<<<<<.<.......<<...<.......>.<<<<.>>>>...>>......>.>>>..>>>........<.<<.<<<<<<<...............>>>>>>>.>>.>....>>....<<<<<.<.....<<<<..<<<.<<<<<<<<...<<<......>>>......>>>>>>>>.>>>.......<<....>>...>>>>.....>>>.>>>...>>>...>>.>....<<<<<<....<...<<<<.........>>>>...>.>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<........>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<......>>>....>>>..))))..].<...<<<<<<<..<<..<<<<<..<<<.<<<<<<.......<........>...........<<<<<......<<<<<<...........<<........>>.........>>>>>>...<<.<<<..<..<<<<<.....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<.<<..<<<<<<<<<<<<..>>>>.>>>>>>>>..>>.>..>.....<<<<<.....>>>>>........>>>.....>>.>>>......>>>>>>.......>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<...<.<<<<<..........>>>>>>....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>..>.......<..<<.<..<<<<.<<....<<<<<<<<.<<<...<<<.<<...<<<<<..<<<<<<<....>>>>>>>....>>>>>...>>.>>>...>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((....[[[..))))(((.((((((...(.((...(.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..(.....(((.....((...((.....((..(.......)..))......))......)).((((...(((((......)))))...))))((..(((((...(......)..)))))......)).(.((((.(((...))))))))...)))....)).).))).(((....((......((((((.........))))))..))......)))...(((.(((......)))....)))))).((.(((..........))).))...((....)).....)))))).).....(.(((...((((.]...))).))))).....)).).....(((.((((..((......))...))))..)).)...(.....(...........)..........)..((((([[......((((.....((..]])).......)))).)))))..)))))).)))..[......(.([[...(.(.((...(((..(....(((...(..)...))).((((...((()))..)).))...((..(.(.......((..((.......)).((...))....))......).)....)).........(.((.(.((((.................)))).).)).)....)....((..((.(.(...((((..(((.(((((((....((........)).......))))))).))).......((....))...))))..)..)))...)..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.((((......)))))))))).)..)))...((..]]))...))...].))))).)..((......((((....))))....))....]]]........(.(((((..((..(((.(..(((.((((((.......(........)...........((((...(...((((((........(..((........))..)......)))))).(.((.(((.....(((..(....(((.((..(....)....(.((......)))...)).)))....(((...(...(..(..((((((((((.(..).)).))))))))...).)..).....(((((.....)))))........))).....)..))).......))))))....)..))))...)).)))).))).(...((.(((........(.......((...(((....)))...))....).........))).))......(.....(((((..........))))).....)..)..).))).....(..((.((.......)).))..)......))...))))).)..........(..((.(..((((.((..(..(((.(.(.(((..((((.((...((((((.((((..((..).).))).).).)))))...)).))))..))).).).))).)..)).))))...).))...).....((((((((......))))))))}........ Structure of the HCV IRES bound to the 40S ribosomal subunit, closed conformation. Structure 6(delta dII); 18S rRNA 7syl z 162 4.5 RF00061 URS00023359E0_2847144 35822879 0043022 2847144 cccccccucccgggagagccauaguggucugcggaaccggugaguacaccggaaugauuugggcgugcccccgcaagacugcuagccgaguaguguugggucgcgaaaggccuugugguacugccugauagggugcuugcgagugccccgggaggucucgua .....<<<<<<<<<<<.<<<<<<<<<<<<<<<<<..<<<<<<....>>>>>><<<.>>>.<<<<..>>>>>>>>>.>>>>>>>><<<.....<<........>>....>>>....>>>>.>><<........>><<...((((.>>>>>>>>>>>.)))).. .....(((((((((((.(((((((..((((((((..((((((....))))))(((.))).((((..)))))))).))))..)))(((.....((........))....)))(..)))))[))((....]...))((...[[[[.))))))))))).]]]].. Structure of the HCV IRES bound to the 40S ribosomal subunit, closed conformation. Structure 6(delta dII); HCV IRES 7sym 2 1697 4.8 RF01960,RF01959,RF00177 URS00023359E5_9986 0003735 0005840 9986 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucgacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgcccggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcggccguccccugcucggcgccggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauuuggcgaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgaccccggucggcguaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggugcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.[[(((.>>>>><<<.<<<<<<...<.<<.........<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<.....<....<<<<.........<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<<<....>>>>>>...>>>><...<<<<<...<......>..>>>>>.......>...<<<<.<<<<.>>>>>>>>..>.>>>...>...>.>>>.<<<....<<<.....<<<<<<.........>>>>>>.>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<<..>>>.>...>>>>>>.........<<<...<<<<.....>>>.>>>>......>>.>......<<.<<<<...<<....>>....>>>>..>>.......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<....<<<.<<<..>>>.>>>.<<<<<<.<<..>>>>>>.>>..<<<.<<.<.......<<...<.......>.<<<<.>>>>...>>......>.>>...>>>........<.<..<<<<<<<...............>>>>>>>..>.>....>>....<<<<<<......<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>.....>>>.>>>...>>>...>>.>....<<<<<<....<...<<<<.........>>>>...>.>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<........>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>...))).]].<...<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<......<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<.<<<<<.....<<<.<<<..<...>.>...<<<......>>>...>>.>>>....<<<.......<<<<..<<<<<<<<<<<<..>>>>.>>>>>>>>..>>>>........<<<<<.....>>>>>........>>>.....>>.>>>.....>>>>>>>.......>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>..>.......<.....<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<..<<<<<<<<..>>>>>>>>....>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>......>.....<<<<<<<<<....>>>>>>>>>......... ...((((....[[[[.))))(((.((((((...(.((..((.....(((.(((........((....((..........))...))[........(((.......(((.(.(........((((....((...((.....((.(((.....))).))......))......)).((((...(((((......)))))...))))....(((((...(......)..))))).........(.((...((((.))))..))).).))).....).).))).(((....(((.....((((((.........)))))).)))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).).......(..(((..(((....)))...)))....).....(.(...(...........)...)......)...(...[[......((((.....((..]])).......)))).....)..)))))).)))..[......(.([[...(.(.((.....(..(.....((...(..)...))..((((((.((())))))).))...((..(.(.......((..(.........).(((.)))....))......).)....)).........(.(..((((((.................))))))..).)....)....(((..(.(.(...((((..((..(((((((....((........)).......)))))))..)).......((....))...))))..)..))...))..)).....)).)....((((((........((((.........)))).....))))))......{...(((.((..((..(.((((((.((((......)))))))))).)..))....((..]]))...))...].))))).)...(......((((....))))....)....]]]]...(....(((((((..((..(((((..(((.((((((......((........))..........((((...(...(((((.....(...(..((........))..).....).)))))...((.(((...(.((((.(......(.((..((...))...(.((......)))...)).)......(((...(....(((..((((((((((((..)))).))))))))..)))...).....(((((.....)))))........))).....)).))).....).))))).....)..))))...)).)))).))).(...((.(((........(.......(((..(((....)))..)))....).........))).))......(.....(((((..........))))).....)..)..))))).....((.((.((.......)).)).))......))...))))))).....)....(.....(..(((...(..(..((((((..(((..((((.((...((((((.((((...(..)...))).).).)))))...)).))))..)))..)))))).)..)...)))...)......).....((((((((......))))))))}........ Structure of the HCV IRES bound to the 40S ribosomal subunit, head opening. Structure 7(delta dII); 18S rRNA 7sym z 162 4.8 RF00061 URS00023359E0_11104 0043022 11104 cccccccucccgggagagccauaguggucugcggaaccggugaguacaccggaaugauuugggcgugcccccgcaagacugcuagccgaguaguguugggucgcgaaaggccuugugguacugccugauagggugcuugcgagugccccgggaggucucgua .....<<<<<<<<<<<.<<<<<<<<<<<<<<<<<..<<<<<<....>>>>>><<...>>.<<<<..>>>>>>>>.>>>>>>>>><<<.....<<........>>....>>>....>>>>.>><.<<.....>>><<..(((((.>>>>>>>>>>>.))))). .....(((((((((((.(((((((((((((((((..((((((....))))))(((.))).((((..)))))))).)))))))))(((.....(..........)....)))(..)))))[))..(...]...).((..[[[[[.))))))))))).]]]]]. Structure of the HCV IRES bound to the 40S ribosomal subunit, head opening. Structure 7(delta dII); HCV IRES 7syn 2 1697 4.0 RF01960,RF01959,RF00177 URS00023359E5_9986 0003735 0005840 9986 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucgacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgcccggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcggccguccccugcucggcgccggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauuuggcgaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgaccccggucggcguaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggugcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.[[((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<....<<....<<<..........<<.....<<.<<.......>>.>>......>>.........<<<<...<<<<<......>>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<...>>>>>>>....>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>...<<<..>>>.....>>>>>>.........<<<....<<<.....>>>..>>>..>...>>.>.....<<<.<<<<..<<<....>>>...>>>>..>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<....<<<.<<<..>>>.>>>.<<<<...<<..>>..>>.>>..<<<<<<.<.......<<...<.......>.<<<<.>>>>...>>......>.>>>..>>>........<.<<.<<<<<<<...............>>>>>>>.>>.>....>>....<<<<<<......<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>.....>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<........>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]].<...<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<......<<<<<<.......<<.<<<........>>>.>>.....>>>>>>.<.<<.<<<.....<<<<<.....<<<.<<.<......>....<<<......>>>...>>.>>>....<<<...<...<.<<..<<<<<<<<<<<<..>>>>.>>>>>>>>..>>.>..>.....<<<<<.....>>>>>........>>>.....>>.>>>.......>>>>>>......>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<..<<<....>>>..>>>....>.........>>>.>>......<...<.<<<<<..........>>>>>>....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>..>.......<..<<.<..<<<<.<<....<<<<<<<<.<<<...<<<.<<...<<<<<..<<.<<<<<..>>>>>.>>....>>>>>...>>.>>>...>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((...[[[[[.))))((..((((((...(.((..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..((....(((.....((...((.....((..((.....))..))......))......)).((((...(((((......)))))...)))).(..(((((...(......)..)))))......)..(.((...(((...)))..)))...)))...))).).))).(((....(((.....((((((.........)))))).)))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).)......((..((((.(((....)))..))))...)).....(.((..(...........)..))......)...(((([[......((((.....((..]])).......)))).))))...))))))..))..[......(.([[...(.(.((...(((..(....(((..((..))..))).((((.(.((()))).)).))..(((.((.(.......((..((.......)).(((.)))....))......).).)..)))........(.(..((((((.................))))))..).)....)....(((.((...(...((((..((..((((((((...((........))......))))))))..)).......((....))...))))..)...))..))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((..((..(.((((((.((.(......).)))))))).)..))....((..]]))...))...].))))).).(((......((((....))))....)))..]]]].]......(((((((..((..(((((..(((..(((((.......(........)...........(((....(...(((((.....(..((..((........))..))....).)))))...((.(((.....((((.(......(.((............(.((......)))...)).)......(((...(...(..(..((((((((((((..)))).))))))))..)..)..).....(((((.....)))))........))).....)).))).......))))).....)...)))...)).)))..))).(...((.(((........(.......(((...((....))...)))....).........))).))......(.....(((((..........))))).....)..)..))))).....(((((.((.......)).)))))......))...)))))))..........(..((.(..(((..((..(..(((((.(.(((..(.((.((...((.(((.((((...(..)...))).).).)).))...)).)).)..)))..)))))).)..))..)))...).))...).....((((((((......))))))))}........ Structure of the HCV IRES bound to the 40S ribosomal subunit, head opening. Structure 8(delta dII); 18S rRNA 7syn z 162 4.0 RF00061 URS00023359E0_11104 0043022 11104 cccccccucccgggagagccauaguggucugcggaaccggugaguacaccggaaugauuugggcgugcccccgcaagacugcuagccgaguaguguugggucgcgaaaggccuugugguacugccugauagggugcuugcgagugccccgggaggucucgua .....<<<<<<<<<<<.<<<<<<<<<<<<<<<<<..<<<<<<....>>>>>><<<.>>>.<<<<..>>>>>>>>.>>>>>>>>><<<.....<<........>>....>>>....>>>>.>><<<<....>>>><<..(((((.>>>>>>>>>>>.))))). .....(((((((((((.((((((((.((((((((..((((((....))))))(((.))).((((..)))))))).)))).))))(((.....((........))....)))(..)))))[)).(((..].))).((...[[[[.))))))))))).]]]].. Structure of the HCV IRES bound to the 40S ribosomal subunit, head opening. Structure 8(delta dII); HCV IRES 7syo 2 1697 4.6 RF01960,RF02542,RF01959,RF00177 URS00023359E5_9986 35822879 0003735 0005840 9986 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucgacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgcccggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcggccguccccugcucggcgccggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauuuggcgaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgaccccggucggcguaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggugcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.[[(((.>>>>><<<.<<<<<<...<.<<..<......<<<.<<<...<....<<....<<..........>>...>>.>.......<<........<<<.<..........<<<<<........<<.....<<..<.......>..>>......>>.........<<<<...<<<<<<....>>>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<..<<<<.>>>>.>>>.>>.>>>.......>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>...<<<..>>>.....>>>>>>.........<<<....<<<.....>>>..>>>..>...>>.>.....<<<..<<<<.<<<....>>>..>>>>...>>>......<<..<...........>..>>..........<<<.((......<<<<.....<<..))>>.......>>>>..>>>...>>>>>>.>>>.........<.<((.....<.<<...<<<.<<....<<<..<<..>>..>>>.<<<<...<<..>>..>>.>>..<<<.<<.<.......<<...<.......>.<<<<.>>>>...>>......>.>>...>>>........<.<<.<<<<<<<...............>>>>>>>.>>.>....>>....<<<<<<......<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>.....>>>.>>>...>>>...>>.>....<<<<<<....<...<<<<.<.....>.>>>>...>.>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<........>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>..<<......<<<......>>>....>>....))).]].<...<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<......<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<.....<<<<<.....<<<.<<.<......>....<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<..>>>>.>>>>>>>>..>>>>..>.....<<<<<.....>>>>>........>>>.....>>.>>>.......>>>>>.......>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<..<<.<<<<<..........>>>>>>>...>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>..>.......<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<..<<<<<<<<..>>>>>>>>....>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((...[[[[..)))).((..((.((...(.((...(.....(((.(((........((....((..........))...))[........(((.......(((...(........(.(.....((...((.....((..((.....))..))......))......)).((((...((((((....))))))...)))).(..(((((...(......)..)))))......)..(.((...((((.))))..)))...).).....)...))).(((....(((.....((((((.........)))))).)))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).....)).).......(..(((..(((....)))...)))....).....(.((..(...........)..))......).......[[......((((.....((..]])).......))))........)).))..))...[......(.([[...(.(.((.....(..(....(((...(())...))).((((.(.((()))).)).))...((.((.(.......((..((.......)).((...))....))......).).)..)).........(.((.((((((.................)))))).)).)....)....(((..(.(.....((((..(((.((((((((...((........))......)))))))).))).......((....))...)))).....))...))..)).....)).)....(((((.....(...((((.........))))...)..)))))......{...(((.((..((....((((((.((((......))))))))))....))....(.(.]]))...))...].))))).).(.(......((((....))))....).)...]]].].(....((((.(...((..(((((..(((.((((((......((........))..........(((((..(...(((((.....(..((..((........))..))....).)))))...((.((.......((..(......(.((............(.((......)))...)).)......(((.(.(...((((..((((((((((((..)))).))))))))..))))..).....(((((.....))))).......)))).....)..)).........)))).....).)))))...)).)))).))).(...((.(((........(.......(((..(((....)))..)))....).........))).))......(.....(((((..........))))).....)..)..))))).....(((((..(.......)..)))))......))....).)))).....)....(..((.(..(((..((..(..(((((((.(((..((((.((...((((((.((((.(.(..).).))).).).)))))...)).))))..))).))))))).)..))..)))...).))...)......(((((((......))))))).}........ Structure of the HCV IRES bound to the 40S ribosomal subunit, head open. Structure 9(delta dII); 18S rRNA 7syo z 166 4.6 RF00061 URS00023359E0_11104 35822879 0043022 11104 cccccccucccgggagagccauaguggucugcggaaccggugaguacaccggaaugauuugggcgugcccccgcaagacugcuagccgaguaguguugggucgcgaaaggccuugugguacugccugauagggugcuugcgagugccccgggaggucucguagacc .....<<<<<<<<<<<.<<<<<<<<<<<<<<<<<..<<<<<<....>>>>>><<...>>.<<<<..>>>>>>>>>.>>>>>>>><<<.....<<........>>....>>>....>>>>.>><<<......>>><<...((((.>>>>>>>>>>>.))))...... .....(((((((((((.(((((((..((((((((..((((((....))))))((...)).((((..)))))))).))))..)))(((.....(..........)....)))(..)))))[))(((...]..)))((....[[[.))))))))))).]]]....... Structure of the HCV IRES bound to the 40S ribosomal subunit, head open. Structure 9(delta dII); HCV IRES 7syp 2 1680 4.0 RF01960,RF02542,RF01959,RF00177 URS00023359E5_9986 35822879 0003735 0005840 9986 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucgacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgcccggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugcucggcgccggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauuuggcgaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgaccccggucggcguaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggugcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<.........<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<......<<....<<<<.........<<.....<<.<<.......>>.>>......>>.........<<<<...<<<<<<....>>>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<...>>>>>>>..>.>>>...>>....>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<<..>>>.>...>>>>>>.........<<<...<<<<.....>>>.>>>>......>>.>.....<<<..<<<..<<<....>>>...>>>...>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<.<.<<....<<<<<<.<<..>>>>>>.>>..<<<<<<.<.......<<...<.......>.<<<<.>>>>...>>......>.>>>..>>>........<.<<.<<<<<<<...............>>>>>>>.>>.>....>>....<<<<<<..<...<<<<..<<<.<<<<<<<<...<<<......>>>......>>>>>>>>.>>>.......<<....>>...>>>>..>..>>>.>>>...>.>...>>.>....<<<<<<....<...<<<<.<.....>.>>>>...>.>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<........>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<......>>>....>>>..)))).]..<...<<<<<<<..<<..<<<<<.<<<<.<<<<<<......<<........>>..........<<<<<......<<<<<<........<..<<........>>.>.......>>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<..>>>>.>>>>>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>>......>>>>>...>>.>>>>.>>>.>...<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>..>.......<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<..<<..............>>....>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[[.))))(((.((((((...(.((...(.....(((.(((...(....((....((..........))...))[).......(((.......(((.(.(..((....(((.....((...((.....((..((.....))..))......))......)).((((...(((((......)))))...))))((..(((((...(......)..)))))......)).(.((((.((.(..))))))))...)))...))).).))).(((....(((.....((((((.........)))))).)))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).....)).).....(((..(((..(((....)))...)))...)).)...(.((..(...........)..))......)...(.(([[......((((.....((..]])).......)))).)).)...)))))).)))..[......(.([[...(.(.((.....(..(....((((.(.((()))).)).))...((.((.(.......((..((.......)).((.()))....))......).))...)).........(.((.((((((.................)))))).)).)....)....((...(.(.(...((((..((..((((((((...((........))......))))))))..)).......((....))...))))..)..))....)..)).....)).)....(((((.....(...((((.........))))...)..)))))......{...(((.((..((..(.((((((.((((......)))))))))).)..))....((..]]))...))...].))))).).(.(......((((....))))....).)..]]]].]......(((((((..((..(((((..(((.((((((.......(........)...........(((((..(...((((((....(...(..((........))..).....)))))))...((.(((...(.((((.(....(((.(((.(....).)..(.((......)))...)).)))....(((...(...(.((..((((((((((((..)))).))))))))..)).)..).....(((((.....)))))........)))....).).))).....).))))).....).)))))...)).)))).))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....(..((.((.......)).))..)......))...)))))))..........(.....(..((((..(..(..(((((((.(((..((((.((...((.(((.((((...(..)...))).).).)).))...)).))))..))).))))))).)..)..))))...)......).....(((((((((....)))))))))}........ Structure of the wt IRES and 40S ribosome binary complex, open conformation. Structure 10(wt); 18S rRNA 7syp z 249 4.0 RF00061 URS00023359E0_11104 35822879 0043022 11104 ccugugaggaacuacugucuucacgcagaaagcgucuagccauggcguuaguaugagugucgugcagccuccaggacccccccucccgggagagccauaguggucugcggaaccggugaguacaccggaaugauuugggcgugcccccgcaagacugcuagccgaguaguguugggucgcgaaaggccuugugguacugccugauagggugcuugcgagugccccgggaggucucguagaccgugcacc <<<<.<<<<.....<<<<...<<<.<<....<<<<<.......>>>>>.....>>.>>>....>>>>>>>>>>>>......<<<<<<<<<<<.<<<<<<<<<<<<<<<<<..<<<<<<....>>>>>><<<.>>>.<<<<..>>>>>>>>>.>>>>>>>><<<.....<<<......>>>....>>>....>>>>.>><<<<....>>>><<..(((((.>>>>>>>>>>>.)))))............ ((((.((((.....(((.(..(((.((....(((((.......))))).....)).)))..)..)))))))))))......(((((((((((..((((((..((((((((..((((((....))))))(((.))).((((..)))))))).))))..)))(((.....(..........)....)))(..)))).[))((((..].))))((..[[[[[.))))))))))).]]]]]............ Structure of the wt IRES and 40S ribosome binary complex, open conformation. Structure 10(wt); HCV IRES 7syq 2 1680 3.8 RF01960,RF02542,RF01959,RF00177 URS00023359E5_9986 35822879 0003735 0005840 9986 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucgacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgcccggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugcucggcgccggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauuuggcgaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgaccccggucggcguaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggugcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.[[((((>>>>><<<.<<<<<<...<.<<.........<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<....<<....<<<<.........<<.....<<..<.......>..>>......>>.........<<<<...<<<<<<....>>>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<.<..>>>>>>>..>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>...<<<..>>>.....>>>>>>.........<<<....<<<.....>>>..>>>......>>.>.....<<<..<<<..<<<....>>>...>>>...>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<.<.<<....<<<<<<.<<..>>>>>>.>>..<<<<<<.<.......<<...<.......>.<<<<.>>>>...>>......>.>>>..>>>........<.<<.<<<<<<<...............>>>>>>>.>>.>....>>....<<<<<<......<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>.....>>>.>>>...>.>...>>.>....<<<<<<....<...<<<<.<.....>.>>>>...>.>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<........>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<......>>>....>>>..)))).]].<...<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<......<<<<<<.......<<.<<<........>>>>.>.....>>>>>>.<.<<.<<<..<<.<<<<<.....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<..>>>>.>>>>>>>>..>>>>..>.....<<<<<.....>>>>>........>>>.....>>.>>>.....>>>>>>>>......>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>..>.......<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<..<<..............>>....>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((...[[[[[.))))(((.((((((...(.((..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..((....(((.....((...((.....((..((.....))..))......))......)).((((...((((((....))))))...)))).(..(((((...(......)..)))))......)..(.((((.((.(..))))))))...)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).).....(((..(((..(........)...)))...)))....(.(...(...........)...)......)..((((([[......((((.....((..]])).......)))).)))))..)))))).)))..[......(.([[...(.(.((.....(..(....((((((.((())))))).))...(((((.(.......((..((.......)).((...))....))......).)))..)).........(.((.((((((.................)))))).)).).....)...(((..(.(.(...((((..((..((((((((...((........))......))))))))..)).......((....))...))))..)..))...))..)).....)).)....(((((.....(...((((.........))))...)..)))))......{...(((.((..((..(.((((((.((((......)))))))))).)..))....((..]]))...))...].))))).).(((......((((....))))....)))..]]]].]......(((((((..((..(((((..(((.((((((.......(........)...........(((((..(...((((((....(...(..((........))..).....)))))))...((.(((.....((((.(....(((.((.((....))...(.((......)))...)).)))....(((...(...((((..((((((((((((..)))).))))))))..))))..).....(((((.....)))))........))).....)).))).......))))).....).)))))...)).)))).))).(...((.(((........(.......(((..(((....)))..)))....).........))).))......(.....(((((..........))))).....)..)..))))).....((.(((.(.......).))).))......))...)))))))..........(..((.(..((((..(..(..(((((((.(((..(.((.((...((((.(.((((...(..)...))).).)..))))...)).)).)..))).))))))).)..)..))))...).))...).....(((((((((....)))))))))}........ Structure of the wt IRES and 40S ribosome ternary complex, open conformation. Structure 11(wt); 18S rRNA 7syq z 264 3.8 RF00061 URS00023359E0_11104 35822879 0043022 11104 ccugugaggaacuacugucuucacgcagaaagcgucuagccauggcguuaguaugagugucgugcagccuccaggacccccccucccgggagagccauaguggucugcggaaccggugaguacaccggaaugauuugggcgugcccccgcaagacugcuagccgaguaguguugggucgcgaaaggccuugugguacugccugauagggugcuugcgagugccccgggaggucucguagaccgugcaccaugagcacgaauccu <<<<.<<<<.....<<<<<..<<<.<<....<<<<.<......>>>>>.....>>.>>>..>.>>>>>>>>>>>>......<<<<<<<<<<<.<<<<<<<<<<<<<<<<<..<<<<<<....>>>>>><<...>>.<<<<..>>>>>>>>>.>>>>>>>><<<.....<<<......>>>....>>>....>>>>.>><<<<....>>>><<..(((((.>>>>>>>>>>>.)))))........................... ((((.((((.....(((.(..(((.((....(((((.......))))).....)).)))..)..)))))))))))......(((((((((((.(((((((.(((((((((..((((((....))))))(((.))).((((..)))))))).))))).)))(((.....(..........)....)))(..)))))[))((((..].))))((..[[[[[.))))))))))).]]]]]........................... Structure of the wt IRES and 40S ribosome ternary complex, open conformation. Structure 11(wt); HCV IRES 7syr 2 1697 3.6 RF01960,RF02542,RF01959,RF00177 URS00023359E5_9986 35822879 0003735 0005840 9986 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucgacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgcccggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcggccguccccugcucggcgccggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauuuggcgaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgaccccggucggcguaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggugcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<.........<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<....<<....<<<<.........<<.....<<..<<.....>>..>>......>>.........<<<<...<<<<<......>>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<...>>>>>>>..>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>...<<<..>>>.....>>>>>>.........<<<....<<<.....>>>..>>>......>>.>.....<<<<<<<<<.............>>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<....<<<.<<<..>>>.>>><<<<<<<.<<..>>>>>>.>>>.<<<<<<.<.......<<...<.......>.<<<<.>>>>...>>......>.>>>..>>>........<.<<.<<<<<<.................>>>>>>.>>.>....>>....<<<<<<......<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>.....>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<......>>>....>>>..)))).]..<...<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<......<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<.<<<<<.....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<..>>>>.>>>>>>>>..>>>>..>.....<<<<<.....>>>>>........>>>.....>>.>>>.....>>>>>>>.......>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>..>.......<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<..<<..<.<....>.>..>>....>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((...(.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..((....(((.....((...((.....((.(((.....))).))......))......)).((((...(((((.(...))))))...)))).(..(((((...(......)..)))))......)..(.((((.((((.)))))))))...)))...))).).))).(((....(((.....((((((.........)))))).)))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).....)).)......((((((((.(........)..)))))).)).....(.(...(...........)...)......)..((((([[......((((.....((..]])).......)))).)))))..)))))).)))..[......(.([[...(.(.((...(((..(....(((.(.(())..)))).((((((.((())))))).))...(((((.(.......((..((.......)).(((.)))....))......).)))..)).........(.((.(.((((.................)))).).)).)....)....(((..(.(.(...((((..((..((((((((...((........))......))))))))..)).......((....))...))))..)..))...))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.((((......)))))))))).)..)))...((..]]))...))...].))))).).(((......((((....))))....)))...]]].](.(...(((((((..((..(((((..(((.((((((......((........))..........(((((..(...(((((.....(..((..((........))..))....).)))))...((.(((...(.((((.(.(..(.(.(((((....)))..(.((......)))...)).).)....(((...(...((((..((((((((((((..)))).))))))))..))))..).....(((((.....)))))........))).)...)).))).....).))))).....).)))))...)).)))).))).(...((.(((........(.......(((..(((....)))..)))....).........))).))......(.....(((((..........))))).....)..)..))))).....(.(((.((.......)).))).)......))...)))))))..)..)....(..((.(..((((.((..(..(((.(((.(((..((((.((...((((((.((((...(..)...))).).).)))))...)).))))..))).))).))).)..)).))))...).))...).....(((((((((....)))))))))}........ Structure of the wt IRES eIF2-containing 48S initiation complex, closed conformation. Structure 12(wt).; 18S rRNA 7syr i 75 3.6 RF00005 URS0000326EAC_9986 35822879 0030533 0006412 9986 agcagaguggcgcagcggaagcgugcugggcccauaacccagaggucgauggaucgaaaccauccucugcuacca <<<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((....[..)))).(((((.......))))).....(((((..]....)))))))))))).... Structure of the wt IRES eIF2-containing 48S initiation complex, closed conformation. Structure 12(wt).; Met-tRNA-i-Met 7syr z 188 3.6 RF00061 URS00023359E0_11104 35822879 0043022 11104 cccccccucccgggagagccauaguggucugcggaaccggugaguacaccggaaugauuugggcgugcccccgcaagacugcuagccgaguaguguugggucgcgaaaggccuugugguacugccugauagggugcuugcgagugccccgggaggucucguagaccgugcaccaugagcacgaauccu .....<<<<<<<<<<<.<<<<<<<<<<<<<<<<<..<<<<<<....>>>>>><<<.>>>.<<<<..>>>>>>>>>.>>>>>>>><<<.....<<........>>....>>>....>>>>.>><<<<....>>>><<...((((.>>>>>>>>>>>.))))............................ .....(((((((((((.((((((((.((((((((..((((((....))))))(((.))).((((..)))))))).)))).))))(((.....(..........)....)))(..)))))[))((((..].))))((...[[[[.))))))))))).]]]]............................ Structure of the wt IRES eIF2-containing 48S initiation complex, closed conformation. Structure 12(wt).; HCV IRES 7sys 2 1697 3.5 RF01960,RF02542,RF01959,RF00177 URS00023359E5_9986 35822879 0003735 0005840 9986 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucgacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgcccggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcggccguccccugcucggcgccggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauuuggcgaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgaccccggucggcguaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggugcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<....<<....<<<<<........<<.....<<..<.......>..>>......>>.........<<<<...<<<<<......>>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<...>>>>>>>.>>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>...<<<..>>>.....>>>>>>.........<<<....<<<.....>>>..>>>..>...>>.>.....<<<<<<<<<.............>>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<....<<<.<<<..>>>.>>><<<<<<<.<<..>>>>>>.>>>.<<<<<<.<.......<<...<.......>.<<<<.>>>>...>>......>.>>>..>>>........<.<<.<<<<<<.................>>>>>>.>>.>....>>....<<<<<<......<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>.....>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<........>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]..<...<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<......<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<.<<<<<.....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<..>>>>.>>>>>>>>..>>>>..>.....<<<<<.....>>>>>........>>>.....>>.>>>.....>>>>>>>.......>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>..>.......<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<..<<....<<..>>....>>....>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..((....(((.....((...((.....((..((.....))..))......))......)).((((...(((((.(...))))))...))))((..(((((...(......)..)))))......)).(.(((..(((...))).))))...)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).)......((((((((.(........)..)))))).)).....(.(...(...........)...)......)..((((([[......((((.....((..]])).......)))).)))))..)))))).)))..[......(.([[...(.(.((...(((..(....(((...(..)...))).((((((.((())))))).))...(((((.(.......((..((.......)).(((.)))....))......).)))..)).........(.((.(.((((.................)))).).)).)....)....(((..(.(.(...((((..(((.((((((((...((........))......)))))))).))).......((....))...))))..)..))...))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.((((......)))))))))).)..)))...((..]]))...))...].))))).).(((......((((....))))....)))...]]].](.....(((((((..((..(((((..(((.((((((......((........))..........(((((..(...(((((.....(..((..((........))..))....).)))))...((.(((...(.((((.(.(..(((.(((((....)))..(.((......)))...)).)))....(((...(...((((..((((((((((((..)))).))))))))..))))..).....(((((.....)))))........))).)...)).))).....).))))).....).)))))...)).)))).))).(...((.(((........(.......(((..(((....)))..)))....).........))).))......(.....(((((..........))))).....)..)..))))).....((((((((.......))))))))......))...))))))).....)....(..((.(..((((..(..(..(((((((.(((..((((.((...((((((.((((...(..)...))).).).)))))...)).))))..))).))))))).)..)..))))...).))...).....(((((((((....)))))))))}........ Structure of the delta dII IRES eIF2-containing 48S initiation complex, closed conformation. Structure 12(delta dII).; 18S rRNA 7sys z 188 3.5 RF00061 URS00023359E0_11104 35822879 0043022 11104 cccccccucccgggagagccauaguggucugcggaaccggugaguacaccggaaugauuugggcgugcccccgcaagacugcuagccgaguaguguugggucgcgaaaggccuugugguacugccugauagggugcuugcgagugccccgggaggucucguagaccgugcaccaugagcacgaauccu .....<<<<<<<<<<<.<<<<<<<<<<<<<<<<<..<<<<<<....>>>>>><<<.>>>.<<<....>>>>>>>>.>>>>>>>><<<.....<<........>>....>>>....>>>>.>><<<<....>>>><<...((((.>>>>>>>>>>>.))))............................ .....(((((((((((.(((((((((((((((((..((((((....))))))(((.))).((((..)))))))).)))))))))(((.....(..........)....)))(..)))))[))((((..].))))((...[[[[.))))))))))).]]]]............................ Structure of the delta dII IRES eIF2-containing 48S initiation complex, closed conformation. Structure 12(delta dII).; HCV IRES 7sys i 75 3.5 RF00005 URS0000326EAC_9986 35822879 0030533 0006412 9986 agcagaguggcgcagcggaagcgugcugggcccauaacccagaggucgauggaucgaaaccauccucugcuacca <<<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((...(((....[..)))..(((((.......))))).....(((((..]....)))))))))))).... Structure of the delta dII IRES eIF2-containing 48S initiation complex, closed conformation. Structure 12(delta dII).; Met-tRNA-i-Met 7syt 2 1697 4.4 RF01960,RF01959,RF00177 URS00023359E5_9986 35822879 0003735 0005840 9986 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucgacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgcccggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcggccguccccugcucggcgccggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauuuggcgaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgaccccggucggcguaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggugcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<.........<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<......<<....<<<<<........<<.....<<..<.......>..>>......>>.........<<<<...<<<<<......>>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<...>>>>>>>.>>.>>>...>>....>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>...<<<..>>>.....>>>>>>.........<<<...<<<<.....>>>.>>>>......>>.>.....<<<.<<<<<.............>>>>>..>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<....<<<.<<<..>>>.>>>.<<<<<<.<<..>>>>>>.>>..<<<.<<.<.......<<...<.......>.<<<<.>>>>...>>......>.>>...>>>........<.<<.<<<<<<.................>>>>>>.>>.>....>>....<<<<<<......<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>.....>>>.>>>...>>>...>>.>....<<<<<<....<...<<<<.<.....>.>>>>...>.>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<........>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<......>>>....>>>..)))).]..<...<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<......<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<.<<<<<.....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<..>>>>.>>>>>>>>..>>>>..>.....<<<<<.....>>>>>........>>>.....>>.>>>.....>>>>>>>.......>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>..>.......<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<..<<..<.<<..>>.>..>>....>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((....[[[..))))(((.((((((...(.((..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..((....(((.....((...((.....((..((.....))..))......))......)).((((...(((((.(...))))))...)))).(..(((((...(......)..)))))......)..(.((((.((.(..))))))))...)))...))).).))).(((....(((.....((((((.........)))))).)))......)))...(((.((((....))))....)))))).((.(((..........))).))...((....)).....)))))).).....(.(((...((((.]...))).))))).)...)).).....(((.((((..(........)...))))..)))....(.((..(...........)..))......)..((((([[......((((.....((..]])).......)))).)))))..)))))).)))..[......(.([[...(.(.((...(((..(....(((...(..)...))).((((((.((())))))).))...((..(.(.......((..((.......)).(((.)))....))......).)....)).........(.((.(.((((.................)))).).)).)....)....(((..(.(.(...((((..(((.((((((((...((........))......)))))))).))).......((....))...))))..)..))...))..))))...)).)....(((((.....(...((((.........))))...)..)))))......{...(((.((..((..(.((((((.((((......)))))))))).)..))....((..]]))...))...].))))).).(.(......((((....))))....).)...]]]........(((((((..((..(((((..(((.((((((......((........))..........(((((..(...(((((.....(..((..((........))..))....).)))))...((.(((.....((((.(.(..(.(.(((((....)))..(.((......)))...)).).)....(((...(...(.((..((((((((((((..)))).))))))))..)).)..).....(((((.....)))))........))).)...)).))).......))))).....).)))))...)).)))).))).(...((.(((........(.......(((..(((....)))..)))....).........))).))......(.....(((((..........))))).....)..)..))))).....(.((((.(.......).)))).)......))...)))))))..........(..((.(..((((.((..(.((((.(((.(((..((((.((...((((((.((((...(..)...))).).).)))))...)).))))..))).))).)))))..)).))))...).))...).....(((((((((....)))))))))}........ Structure of the wt IRES w/o eIF2 48S initiation complex, closed conformation. Structure 13(wt); 18S rRNA 7syt i 75 4.4 RF00005 URS0000326EAC_9986 35822879 0030533 0006412 9986 agcagaguggcgcagcggaagcgugcugggcccauaacccagaggucgauggaucgaaaccauccucugcuacca <<<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((...(((....[..)))..(((((.......))))).....(((((..]....)))))))))))).... Structure of the wt IRES w/o eIF2 48S initiation complex, closed conformation. Structure 13(wt); Met-tRNA-i-Met 7syt z 188 4.4 RF00061 URS00023359E0_11104 35822879 0043022 11104 cccccccucccgggagagccauaguggucugcggaaccggugaguacaccggaaugauuugggcgugcccccgcaagacugcuagccgaguaguguugggucgcgaaaggccuugugguacugccugauagggugcuugcgagugccccgggaggucucguagaccgugcaccaugagcacgaauccu .....<<<<<<<<<<<.<<<<<<<<<<<<<<<<<..<<<<<......>>>>><<<.>>>.<<<<..>>>>>>>>.>>>>>>>>><<<.....<<........>>....>>>....>>>>.>><<<<....>>>><<..(((((.>>>>>>>>>>>.)))))........................... .....(((((((((((.(((((((((((((((((..((((((....))))))(((.))).((((..)))))))).)))))))))(((.....(..........)....)))(..)))))[))(((...]..)))((...[[[[.))))))))))).]]]]............................ Structure of the wt IRES w/o eIF2 48S initiation complex, closed conformation. Structure 13(wt); HCV IRES 7syu 2 1697 4.6 RF01960,RF01959,RF00177 URS00023359E5_9986 35822879 0003735 0005840 9986 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucgacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgcccggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcggccguccccugcucggcgccggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauuuggcgaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgaccccggucggcguaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggugcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<...((((>>>>><<<.<<<<<<...<.<<.........<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<....<<....<<<<<........<<.....<<..<.......>..>>......>>.........<<<<...<<<<<......>>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<...>>>>>>>.>>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>...<<<..>>>.....>>>>>>.........<<<...<<<<.....>>>.>>>>......>>.>.....<<<.<<<<<.............>>>>>..>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<....<<<.<<<..>>>.>>><<<<<<<.<<..>>>>>>.>>>.<<<.<<.<.......<<...<.......>.<<<<.>>>>...>>......>.>>...>>>........<.<<.<<<<<<.................>>>>>>.>>.>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<....<...<<<<.<.....>.>>>>...>.>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<........>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..))))....<...<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<......<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<.<<<<<.....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<..>>>>.>>>>>>>>..>>>>..>.....<<<<<.....>>>>>........>>>.....>>.>>>.....>>>>>>>.......>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>..>.......<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<..<<.<<.<<..>>.>>.>>....>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((....[[[..))))(((.((((((...(.((...(.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..((....(((.....((...((.....((..((.....))..))......))......)).((((...(((((.(...))))))...))))((..((.((...(......)..)).))......)).(.((.(.((.(..)))).)))...)))...))).).))).(((....(((.....((((((.........)))))).)))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).....)).).....((((((((..(........)...))))).)))....(.(...(...........)...)......)..((((([[......((((.....((..]])).......)))).)))))..)))))).)))..[......(.([[...(.(.((...(((..(....(((...(..)...))).((((((.((())))))).))...((..(.(.......((..((.......)).(((.)))....))......).)....)).........(.((.(.((((.................)))).).)).)....)....(((..(.(.(...((((..(((.((((((((...((........))......)))))))).))).......((....))...))))..)..))...))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((..((..(.((((((.((((......)))))))))).)..))....((..]]))...))...].))))).).(((......((((....))))....)))...]]]........(((((((..((..(((((..(((.((((((......((........))..........(((((..(...(((((.....(..((..((........))..))....).)))))...((.(((...(.((((.(.(..(((.(((((....)))..(.((......)))...)).)))....(((...(...(.((...(((((((((((..)))).)))))))...)).)..).....(((((.....)))))........))).)...)).))).....).))))).....).)))))...)).)))).))).(...((.(((........(.......(((..(((....)))..)))....).........))).))......(.....(((((..........))))).....)..)..))))).....((((((((.......))))))))......))...)))))))..........(..((.(..((((.((..(.((((.(((.(((..((((.((...((((((.((((...(..)...))).).).)))))...)).))))..))).))).)))))..)).))))...).))...).....(((((((((....)))))))))}........ Structure of the delta dII IRES w/o eIF2 48S initiation complex, closed conformation. Structure 13(delta dII); 18S rRNA 7syu z 188 4.6 RF00061 URS00023359E0_11104 35822879 0043022 11104 cccccccucccgggagagccauaguggucugcggaaccggugaguacaccggaaugauuugggcgugcccccgcaagacugcuagccgaguaguguugggucgcgaaaggccuugugguacugccugauagggugcuugcgagugccccgggaggucucguagaccgugcaccaugagcacgaauccu .....<<<<<<<<<<<.<<<<<<<<<<<<<<<<<..<<<<<<....>>>>>><<...>>.<<<<..>>>>>>>>.>>>>>>>>><<<.....<<........>>....>>>....>>>>.>><<<......>>><<..(((((.>>>>>>>>>>>.)))))........................... .....(((((((((((..((((((((((((((((..((((((....))))))(((.))).((((..)))))))).)))))))))(((.....(..........)....)))(..)))).[))(((...]..)))((...[[[[.))))))))))).]]]]............................ Structure of the delta dII IRES w/o eIF2 48S initiation complex, closed conformation. Structure 13(delta dII); HCV IRES 7syu i 75 4.6 RF00005 URS0000326EAC_9986 35822879 0030533 0006412 9986 agcagaguggcgcagcggaagcgugcugggcccauaacccagaggucgauggaucgaaaccauccucugcuacca <<<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((....[..)))).(((((.......))))).....(((((..]....)))))))))))).... Structure of the delta dII IRES w/o eIF2 48S initiation complex, closed conformation. Structure 13(delta dII); Met-tRNA-i-Met 7syv 2 1680 3.9 RF01960,RF02542,RF01959,RF00177 URS00023359E5_9986 35822879 0003735 0005840 9986 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucgacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgcccggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugcucggcgccggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauuuggcgaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgaccccggucggcguaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggugcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<.........<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<....<<....<<<<.........<<.....<<.<<.......>>.>>......>>.........<<<<...<<<<<<....>>>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<...>>>>>>>..>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<<..>>>.>...>>>>>>.........<<<...<<<<.....>>>.>>>>......>>.>.....<<<.<<<<..<<<....>>>...>>>>..>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<....<<<<<..<<..>>.>>>.>>..<<<<<<.<.......<<...<.......>.<<<<.>>>>...>>......>.>>>..>>>........<.<<.<<<<<<<...............>>>>>>>.>>.>....>>....<<<<<<......<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>.....>>>.>>>...>>>...>>.>....<<<<<.<...<...<<<<.<.....>.>>>>...>>.>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<........>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<......>>>....>>>..))))..].....<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<......<<<<<<...........<<........>>.........>>>>>>...<<.<<<...<.<<<<<.....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<..>>>>.>>>>>>>>..>>>>..>.....<<<<<.....>>>>>........>>>.....>>.>>>.....>.>>>>>.......>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>..........<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<..<<<...........>.>>....>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((...[[[[..))))(((.((((((...(.((..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..((....(((.....((...((.....((..((.....))..))......))......)).((((...(((((......)))))...))))((..(((((...(......)..)))))......)).(.((((.((.(..))))))))...)))...))).).))).(((....(((.....((((((.........)))))).)))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).).......(..(((..(((....)))...)))....).....(.((..(...........)..))......)..((((([[......((((.....((..]])).......)))).)))))..)))))).)))..[......(.([[...(.(.((.....(..(....((((...((()))..)).))..(((.((.(.......((..((.......)).((...))....))......).))...)))........(.((.(.((((.................)))).).)).)....)....(((..(.(.(...((((..(((.((((((((...((........))......)))))))).))).......((....))...))))..)..))...))..)).....)).)....(((((.....(...((((.........))))...)..)))))......{...(((.((..((..(.((((((.((((......)))))))))).)..))....((..]]))...))...].))))).).(((......((((....))))....)))...]]].]......(((((((..((..(((((..(((.((((((.......(........)...........((((...(...((((((....(...(..((........))..).....)))))))...((.(((.....((((.(....(((.((..(....)....(.((......)))...)).)))....(((...(...((((..((((((((((((..)))).))))))))..))))..).....(((((.....)))))........)))....).).))).......))))).....)..))))...)).)))).))).(...((.(((........(.......(((..(((....)))..)))....).........))).))......(.....(((((..........))))).....)..)..))))).....(..((..(.......)..))..)......))...)))))))..........(..((.(..((((.((..(..(((((((.(((..((((.((...((.(((.((((...(..)...))).).).)).))...)).))))..))).))))))).)..)).))))...).))...).....(((((((((....)))))))))}........ Structure of the wt IRES eIF5B-containing pre-48S initiation complex, open conformation. Structure 14(wt); 18S rRNA 7syv i 75 3.9 RF00005 URS0000326EAC_9986 35822879 0030533 0006412 9986 agcagaguggcgcagcggaagcgugcugggcccauaacccagaggucgauggaucgaaaccauccucugcuacca .<<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... (((((((..((((.......)))).(((((.......))))).....(((((.......)))))))))))).... Structure of the wt IRES eIF5B-containing pre-48S initiation complex, open conformation. Structure 14(wt); Met-tRNA-i-Met 7syv z 258 3.9 RF00061 URS00023359E0_2847144 35822879 0043022 2847144 ccugugaggaacuacugucuucacgcagaaagcgucuagccauggcguuaguaugagugucgugcagccuccaggacccccccucccgggagagccauaguggucugcggaaccggugaguacaccggaaugauuugggcgugcccccgcaagacugcuagccgaguaguguugggucgcgaaaggccuugugguacugccugauagggugcuugcgagugccccgggaggucucguagaccgugcaccaugagcacg <<<<.<<<<.....<<<<...<<<.<<....<<<<<.......>>>>>.....>>.>>>....>>>>>>>>>>>>......<<<<<<<<<<<.<<<<<<<<<<<<<<<<<..<<<<<<....>>>>>><<<.>>>.<<<<..>>>>>>>>>.>>>>>>>><<<.....<<<......>>>....>>>....>>>>.>><<<<....>>>><<..(((((.>>>>>>>>>>>.)))))..................... ((((.((((.....(((((..(((.((....(((((.......))))).....)).)))..).))))))))))))......(((((((((((..((((((.(((((((((..((((((....))))))(((.))).((((..)))))))).))))).)))(((.....(..........)....)))(..)))).[))((((..].))))((..[[[[[.))))))))))).]]]]]..................... Structure of the wt IRES eIF5B-containing pre-48S initiation complex, open conformation. Structure 14(wt); HCV IRES 7syw 2 1697 3.7 RF01960,RF01959,RF00177 URS00023359E5_9986 35822879 0003735 0005840 9986 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucgacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgcccggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcggccguccccugcucggcgccggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauuuggcgaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgaccccggucggcguaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggugcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.[[((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<....<<....<<<<.........<<.....<<..<.......>..>>......>>.........<<<<...<<<<<......>>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<.<..>>>>>>>..>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>...<<....>>.....>>>>>>.........<<<....<<<.....>>>..>>>..>...>>.>.....<<<<<<<<<.............>>>>>>.>>>......<<..<...........>..>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<....<<<.<<<..>>>.>>>.<<<<<<.<<..>>>>>>.>>..<<<.<<.<.......<<...<.......>.<<<<.>>>>...>>......>.>>...>>>........<.<<.<<<<<<<...............>>>>>>>.>>.>....>>....<<<<<<......<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>.....>>>.>>>...>>>...>>.>....<<<<<<....<...<<<<.<.....>.>>>>...>.>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<........>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<......>>>....>>>..)))).]].<...<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<......<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<.....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<..>>>>.>>>>>>>>..>>>>..>.....<<<<<.....>>>>>........>>>.....>>.>>>.....>>>>>>>.......>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<..<<<....>>>..>>>....>.........>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>..>.......<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<..<<....<<..>>....>>....>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((....[[[..))))(((.((((((...(.((..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..((....(((.....((...((.....((..((.....))..))......))......)).((((...(((((.(...))))))...))))((..(((((...(......)..)))))......)).(.(((..((.(..))).))))...)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).).....((((((((..(..(...).)...))))).)))....(.((..(...........)..))......)..((((([[......((((.....((..]])).......)))).)))))..)))))).)))..[......(.([[...(.(.((...(((..(....(((...(..)...))).((((.(.((()))).)).)).(.((..(.(.......((..((.......)).(((.)))....))......).)....))..)......(.((.(.((((.................)))).).)).)....)....(((..(.(.(...((((..(((.((((((((...((........))......)))))))).))).......((....))...))))..)..))...))..))))...)).)....(((((.....(...((((.........))))...)..)))))......{...(((.((.(((..(.((((((.((((......)))))))))).)..)))...((..]]))...))...].))))).).(((......((((....))))....)))...]]]........(((((((..((..(((((..(((.((((((......((........))..........(((((..(...(((((.....(...(..((........))..).....).)))))...((.(((...(.((((.(.(..(((.((.((....))...(.((......)))...)).)))....(((...(...((((..((((((((((((..)))).))))))))..))))..).....(((((.....)))))........))).)...)).))).....).))))).....).)))))...)).)))).))).(...((.(((........(.......(((...((....))...)))....).........))).))......(.....(((((..........))))).....)..)..))))).....((.(((((.......))))).))......))...)))))))..........(..((.(..((((.((..(..(((((((.(((..(.((.((...((((((.((((.(.(..)..)))).).).)))))...)).)).)..))).))))))).)..)).))))...).))...).....(((((((((....)))))))))}........ Structure of the wt IRES eIF5B-containing 48S initiation complex, closed conformation. Structure 15(wt); 18S rRNA 7syw i 75 3.7 RF00005 URS0000326EAC_9986 35822879 0030533 0006412 9986 agcagaguggcgcagcggaagcgugcugggcccauaacccagaggucgauggaucgaaaccauccucugcuacca <<<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.......)))).(((((.......))))).....(((((.......)))))))))))).... Structure of the wt IRES eIF5B-containing 48S initiation complex, closed conformation. Structure 15(wt); Met-tRNA-i-Met 7syw z 188 3.7 RF00061 URS00023359E0_11104 35822879 0043022 11104 cccccccucccgggagagccauaguggucugcggaaccggugaguacaccggaaugauuugggcgugcccccgcaagacugcuagccgaguaguguugggucgcgaaaggccuugugguacugccugauagggugcuugcgagugccccgggaggucucguagaccgugcaccaugagcacgaauccu .....<<<<<<<<<<<.<<<<<<<<<<<<<<<<<..<<<<<<....>>>>>><<<.>>>.<<<....>>>>>>>>.>>>>>>>><<<.....<<........>>....>>>....>>>>.>><<<<....>>>><<...((((.>>>>>>>>>>>.))))............................ .....(((((((((((..((((((((((((((((..((((((....))))))(((.))).((((..)))))))).)))))))))(((.....((........))....)))(..)))).[))((((..].))))((...[[[[.))))))))))).]]]]............................ Structure of the wt IRES eIF5B-containing 48S initiation complex, closed conformation. Structure 15(wt); HCV IRES 7syx 2 1697 3.7 RF01960,RF01959,RF00177 URS00023359E5_9986 35822879 0003735 0005840 9986 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucgacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgcccggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcggccguccccugcucggcgccggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauuuggcgaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgaccccggucggcguaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggugcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<.........<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<....<<....<<<<.........<<.....<<.<<.......>>.>>......>>.........<<<<...<<<<<......>>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<.<..>>>>>>>..>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>...<<<..>>>.....>>>>>>.........<<<....<<<.....>>>..>>>......>>.>.....<<<.<<<<<.............>>>>>..>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<....<<<...<..>...>>>.<<<<<<.<<..>>>>>>.>>..<<<.<<.<.......<<...<.......>.<<<<.>>>>...>>......>.>>...>>>........<.<<.<<<<<<.................>>>>>>.>>.>....>>....<<<<<<......<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>.....>>>.>>>...>>>...>>.>....<<<<<<....<...<<<<.<.....>.>>>>...>.>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<........>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]..<...<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<......<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<.<<<<<.....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<..>>>>.>>>>>>>>..>>>>..>.....<<<<<.....>>>>>........>>>.....>>.>>>.....>>>>>>>.......>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<..<<<....>>>..>>>....>.........>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>..>.......<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<..<<...<<<..>>>...>>....>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..(.....(((.....((...((.....((..((.....))..))......))......)).((((...(((((.(...))))))...))))((..(((((...(......)..)))))......)).(.((((.((.(..))))))))...)))....)).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).))...((....)).....)))))).).....(.(((...((((.]...))).))))).)...)).).....(((.((((..(..(....))...))))..)))....(.((..(...........)..))......)..((((([[......((((.....((..]])).......)))).)))))..)))))).)))..[......(.([[...(.(.((...(((..(....(((...(..)...))).((((.(.((()))).)).))...((.((.(.......((..((.......)).(((.)))....))......).).)..)).........(.((.(.((((.................)))).).)).)....)....(((.((.(.(...((((..(((.((((((((...((........))......)))))))).))).......((....))...))))..)..)))..))..))))...)).)....((((((....(...((((.........))))...).))))))..........(((.((.(((..(.((((((.((((......)))))))))).)..)))...((..]]))...))...].))))).).(((......((((....))))....)))...]]].](.....(((((((..((..(((((..(((.((((((......((........))..........((((...(...(((((.....(......((........))........).)))))...((.(((...(.((((.(....(((.((..(....)....(.((......)))...)).)))....(((...(...(.((..((((((((((((..)))).))))))))..)).)..).....(((((.....)))))........))).....)).))).....).))))).....)..))))...)).)))).))).(...((.(((........(.......(((...((....))...)))....).........))).))......(.....(((((..........))))).....)..)..))))).....((.(((((.......))))).))......))...))))))).....)....(..((.(..((((.((..(.((((((((.(((..(.((.((...((((((.((((.(.(..)..)))).).).)))))...)).)).)..))).)))))))))..)).))))...).))...).....(((((((((....)))))))))......... Structure of the delta dII IRES eIF5B-containing 48S initiation complex, closed conformation. Structure 15(delta dII); 18S rRNA 7syx i 75 3.7 RF00005 URS0000326EAC_9986 35822879 0030533 0006412 9986 agcagaguggcgcagcggaagcgugcugggcccauaacccagaggucgauggaucgaaaccauccucugcuacca <<<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.......)))).(((((.......))))).....(((((.......)))))))))))).... Structure of the delta dII IRES eIF5B-containing 48S initiation complex, closed conformation. Structure 15(delta dII); Met-tRNA-i-Met 7syx z 188 3.7 RF00061 URS00023359E0_11104 35822879 0043022 11104 cccccccucccgggagagccauaguggucugcggaaccggugaguacaccggaaugauuugggcgugcccccgcaagacugcuagccgaguaguguugggucgcgaaaggccuugugguacugccugauagggugcuugcgagugccccgggaggucucguagaccgugcaccaugagcacgaauccu .....<<<<<<<<<<<.<<<<<<<<<<<<<<<<<..<<<<<<....>>>>>><<<.>>>.<<<....>>>>>>>.>>>>>>>>><<<.....<<........>>....>>>....>>>>.>><<<<....>>>><<...((((.>>>>>>>>>>>.))))............................ .....(((((((((((.(((((((..((((((((..((((((....))))))(((.))).((((..)))))))).))))..)))(((.....((........))....)))(..)))))[))((((..].))))((...[[[[.))))))))))).]]]]............................ Structure of the delta dII IRES eIF5B-containing 48S initiation complex, closed conformation. Structure 15(delta dII); HCV IRES 7tj2 G 31 3.2 URS0000CBFF1E_32630 35801916,35262076 32630 uaguagguuguauaguaguaagaccagaccc ............................... ............................... SARS-CoV-2 endoribonuclease Nsp15 bound to dsRNA; RNA (31-MER) 7tj2 H 31 3.2 URS0000CBFF4E_32630 35801916,35262076 32630 gggucuggucuuacuacuauacaaccuacua ............................... ............................... SARS-CoV-2 endoribonuclease Nsp15 bound to dsRNA; RNA (31-MER) 7tm3 q 76 3.25 RF00005 URS0002617744_9986 36261528 0030533 9986 gucuccguaguguagcgguuaucacguucgccuaacacgcgaaagguccucgguucgaaaccgggcggaaacacca <<.<<<<..<<<..........>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>.>>.... ((.((((..(((.....[....))).(((((.......))))).....(((((..]....))))))))).)).... Structure of the rabbit 80S ribosome stalled on a 2-TMD Rhodopsin intermediate in complex with the multipass translocon; P-site tRNA 7tm3 u 120 3.25 RF00001 URS000002B0D5_9986 36261528 0003735 0005840 9986 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. Structure of the rabbit 80S ribosome stalled on a 2-TMD Rhodopsin intermediate in complex with the multipass translocon; 5S ribosomal RNA 7tm3 v 156 3.25 RF00002,RF02540 URS00004B2C76_9986 36261528 0003735 0005840 9986 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<<<<....>>>>.....<.<<<......>>.............>>>..>...>>>....<<<..>>><<<<<<<<.......>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))((((((((.......)))))))).................... Structure of the rabbit 80S ribosome stalled on a 2-TMD Rhodopsin intermediate in complex with the multipass translocon; 5.8S ribosomal RNA 7tm3 K 3543 3.25 RF02543 URS0000A7632C_9986 36261528 0003735 0005840 9986 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggaaauguggcguacggaagacccacuccccggcgccggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcgcgguccggccgugccggcggggcggaucucccgcucccgucggcgggggaccgccccccggccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggccccggcggggaagguggcccgggggccccggguguuacagccccgccccggcagcagcagcucgccgaaucccggggccgagggagcgagacccgugcgccgcgcucuccccccucgggggggccgggccaccccucccacggcgcgaccgcuggggcggacuguccagugcgccccgggcgggucgcgccgucgggcccggggggccacgcgucccccgcgagcgcacggggucggcggcgaugucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcuacgaaagccgccguggcgcaaugaaggugaaggccggcggcgcgccgccggccgaggugggaucccgaggccuuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcgaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccaaaguuucccucaggauagcuggcgcucuccgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcugguguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggaugguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgcuggcagucggcagagcgagaaagagaguggcgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucagccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcuggcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacguuuuuucacugacccggugaggcgggggggcgagccgggcucucgcuucuggcgccaagcgcccggccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauagcgccggagccucgguuggccucggauagccggucccccgccgggguccggugcggagagcccuucgucccgggaaacggggcggccggaaagggggccgcccucucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcugcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..[[[..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>>..<<<<<<<<<....<<<<<<<<..<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>...>>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<.<....<<<<<<<<.<<<.....<<<<<<<<<<....<<<<<<<.<<<<<.<<<<<<<.<<<<<<<<<......>>>>>>>>>>>>>>>>>>>>>>>>>...>>>.>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<<<<<<<<<<<<<<<<<...<<..<<<..<<<<<<<......<<<<<<<...>>>>>>>.......>>>>>>>..>>>.........>>>>>>..>>>>>>>>>>>.....<<.......>>.........<...<<<<<<..>>>>>>...<.<<...<<.<<<<<<<<<<<<<<<<<.<<<<<.<<<<..>>>>.>>>>>..>>>.>>>>>>>>>>>.>>>...>>.>>.>................>........>>>.>>>>>....>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<.....>>>>.....>>>...<<....>>...<<<<<<<<<<..>>>>>>>>>>..<<<<<...<<<..<<<....[[.[[.>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<<<...<<<....<<<..<.<<<..<<.<.<.<.....>.>.>.>>>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>>>>>>.>>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>......................>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<....................]].]].............>>>>>>>>>....>>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<<<<<...>>>>>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<..<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<<<<<<<<<<<<..{{{..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>.>.>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<.<<<<<<<<<<<.>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<....<<<<<....>>>>.>...>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<<.<<<<<<<<<..>>>>>>>>>...<<<<<.....<<<<..<<.<.<<..>.>>.>>..............<<<<<<<<<..>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>><<<<....>>>>>>)))]......((((((..(((..>>>>>>.)))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]].....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<}}}.>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.<<<<<<...<<<<....<<<........<<<<<..<<<<<.>>>>>.>>>>>.......>>>...<<<..<<<<....<<<<<<<<<........>>>>>>.>>>...>>>>..>>>..............>>>>....>>>>>>.<<<<<.<.............>....<<.<<<<<<<.<<.....<<<<....<<<<<.>>>>>...>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..(((((((((((.....)))))).))))....))))....(((((((((.....(((.(((..((((((((..({((((......)))))....[[(...).(((....}]])))...).)))))))...))).)))....)))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....((((((((((.(..(((((.(.(((((.(((((((.((.(((..(......)..))).))))))))))))))).))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((..(((((((......((((((((.)))))))).......)))))))..))).........))))))..))))))))))).....((.....{.)).........(...((((((..))))))...(.((...((.((((((((((((((..(.(((((.((((..)))).)))))..)...))))))))))).)))...)).)).)............[...)........))).)))))...)))))...)))))))).<((((........))))((((((....(((((((((((((..(((..(((((.....))))..)..)))...((....))...((((((((((..))))))))))..(((((...(((..(((]...[[.[[[)))..)))....))))).(((((((((.((((......))))))))))).))....)))))))))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)<)))...(((..((.((.......B)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((...(((.((((((((....(((....(((..(.(((..((.((..(.....)..)).))))).)..)))..)).)....))))))...(((((((((.(......))))))))))....))))))))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[.....(.(((((......(..........(((.((((((((((.....A...(....(....(...........)....)...........(......)......).....)))))))))))))..........]]].)....)))))).)))...)))))))((((((.(((........}.........].]].]].............)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...((....(((....)))..........((.((((.((((...)))).))))))......))....))...(((((........)))))]]((((....(((((...(((((((....)))))))..((((....)))...(...((((((...(((((((((((((((((((((((...{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((.)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(..(((.....((((....)))).....))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.(((((((((.(((((.(((()))).)))))...(((((.....((((..((....(..)....))..............(((((((((())))))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((.(.(..(((((...((.......))...)))))....)).).)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..b.))..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}..)))))..)).))...))))...)))).((((...((((.....a.......))))...))))..)))...).)))))).((((((...((((....(((.........((((...((((.))))..))))........)))...(((..(((.....(((..((((........))))...)))....)))..)))..............))))....)))))).(((((.(..(.......)..)....((.(((((((.((.....((((.(..(((((.)))))..)))))....))....)))).))).))..))))).. Structure of the rabbit 80S ribosome stalled on a 2-TMD Rhodopsin intermediate in complex with the multipass translocon; 28S ribosomal RNA 7tnx B 12 3.54 URS0002617748_9606 36272408 9606 ngacguacguuu ............ ............ Cryo-EM structure of RIG-I in complex with p3dsRNA; p3dsRNAa 7tnx C 12 3.54 URS0002617750_9606 36272408 9606 cgacguacgucc ............ ............ Cryo-EM structure of RIG-I in complex with p3dsRNA; p3dsRNAb 7tny B 12 3.2 URS0002617749_9606 36272408 9606 ngacguacgucg ............ ............ Cryo-EM structure of RIG-I in complex with p2dsRNA; p2dsRNA 7tny C 12 3.2 URS0002617749_9606 36272408 9606 cgacguacgucc ............ ............ Cryo-EM structure of RIG-I in complex with p2dsRNA; p2dsRNA 7tnz B 12 3.54 URS000261774F_9606 36272408 9606 ngacguacgucg ............ ............ Cryo-EM structure of RIG-I in complex with p1dsRNA; p1dsRNA 7tnz C 12 3.54 URS000261774F_9606 36272408 9606 cgacguacgucc ............ ............ Cryo-EM structure of RIG-I in complex with p1dsRNA; p1dsRNA 7to0 B 12 3.5 URS0002617749_9606 36272408 9606 ggacguacgucg ............ ............ Cryo-EM structure of RIG-I in complex with OHdsRNA; OHdsRNA 7to0 C 12 3.5 URS0002617749_9606 36272408 9606 cgacguacgucc ............ ............ Cryo-EM structure of RIG-I in complex with OHdsRNA; OHdsRNA 7too A25S 3194 2.7 RF02540,RF02543 URS000061F377_4932 35589706 0003735 0005840 4932 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........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((.(((((((((((((...(.((((......)))))[[(...).(((.....]])))....))))))))..))))).))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((......((((.(....).)))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((....(....)..)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.......(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...((((((...((.....)).))))))....[[(((.((...((....(((....))).........(((.((.....).).))).....))....))...(((((........)))))]]((((..(((((.(...((((....)))...(.<.((((((...((((.((((((((((((((((((..{{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....).))..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((((.(..)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((((((...(............(..(...((....)).............)..)...)...).))))))))))....((((.....((((..((((........))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}}.)))))..)))))...))))..))))).((((...((((.............))))...)))).))))....)))))))).......(((((..(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).)))..)))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(((.((..)..).)))..)))))...)))....)))).)))))).))))).. Yeast 80S ribosome bound with the ALS/FTD-associated dipeptide repeat protein GR20; 25S rRNA 7too A58S 158 2.7 RF00002 URS00001BF64E_4932 35589706 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Yeast 80S ribosome bound with the ALS/FTD-associated dipeptide repeat protein GR20; 5.8S rRNA 7too A5S 121 2.7 RF00001 URS000055688D_4932 35589706 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Yeast 80S ribosome bound with the ALS/FTD-associated dipeptide repeat protein GR20; 5S rRNA 7too APTN 77 2.7 RF00005 URS000041AF00_562 35589706 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Yeast 80S ribosome bound with the ALS/FTD-associated dipeptide repeat protein GR20; tRNAfMet 7top A25S 3194 2.4 RF02540,RF02543 URS000061F377_4932 35589706 0003735 0005840 4932 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........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((......((((.(....).)))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).<((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))....))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.(((....(.(...))..))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.......(((((..(.....(.........).....)......(..............).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...((((((...((.....)).))))))....[[(((.((...((....(((....)))........(((..............)))....))....))...(((((........)))))]]((((..(((...(...((((....)))...(.[[((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....).....))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.((((((((.........))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.(((..(((...............(..(......).............).....)).).).)).)))))))...(((((.....((((..(((..........)))..........]]...((((((....))))))..))))..))))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.............))))...)))).))))....)))))))).......((((.(.(((.((....((.(........((((((.....)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).).))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(.(..(..)....).)..)))))...)))....)))).)))))).))))).. Yeast 80S ribosome bound with the ALS/FTD-associated dipeptide repeat protein PR20; 25S rRNA 7top A58S 158 2.4 RF00002 URS00001BF64E_4932 35589706 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Yeast 80S ribosome bound with the ALS/FTD-associated dipeptide repeat protein PR20; 5.8S rRNA 7top A5S 121 2.4 RF00001 URS000055688D_4932 35589706 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Yeast 80S ribosome bound with the ALS/FTD-associated dipeptide repeat protein PR20; 5S rRNA 7top APTN 77 2.4 RF00005 URS000041AF00_562 35589706 0030533 0006412 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(((((.......)))))))))))..... Yeast 80S ribosome bound with the ALS/FTD-associated dipeptide repeat protein PR20; tRNAfMet 7toq A18S 1690 3.1 RF01960,RF01959,RF00177 URS0000EEACE6_9986 35589706 0003735 0005840 9986 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucguacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgcccggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgauaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcggccguccccugcggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgaccccggucggcguaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggugcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<......<<....<<<...........<<.....<<..<<.....>>..>>......>>.........<<<<...<<<<<<....>>>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<<.>>>>>>>>....>>>...>>....>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....<<<<<<<<<.<<<....>>>..>>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<....<<<.<<<..>>>.>>><<<........>>>.<<<<<<.<.......<<...<.......>..<<<.>>>....>>......>.>>>..>>>........<.<..<<<<<<<...............>>>>>>>..>.>....>>....<<<<<<..<...<<<<..<<<.<<<<<<<<...<<<......>>>......>>>>>>>>.>>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<<....>>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<.<<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<<.......<<.<<<........>>>.>>.....>>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<..>>>>.>>>>>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>>....>.>>>>>...>>.>>>>.>>>.>...<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<...<.<<<<<..........>>>>>>....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<<<<<<<<<<<..>>>>>>>>>.>.>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..(.....(((.....(([...((.....((.(((.....))).))......))......))..(((...((((((....))))))...))).((..(((((...(......)..)))))......)).(]((((.((((.)))))))))...)))....)).).))).(((....((.....(((((((.........))))))).))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).).....(((((((((.(((....)))..)))))).)))....(.((..(...........)..))......)..((((([[......((((.....((..]])).......)))).)))))..)))))).)))..[......(.([[...(.(.((....((.((....(((..((()))..))).((........))..((((((.(.......((..((.......)).(((.)))....))......).)))..)))........(.((.(((((((...............))))))).)).)....))...((..((...(...((((..((..((((((((...((........))......))))))))..)).......((....))...))))..)...))...)..)))....)).)....((((((....(...((((.........))))...).))))))......{...(((.((..((..(.((((((.(((((....))))))))))).)..))....((..]]))...))...].))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((..(((((.......(........)...........(((((.(....(((((.....(..((..((........))..))....).)))))....(.(((...(.((((((....(((.((.((....))...(.((......)))...)).)))....(((...(...((((..((((((((((((..)))).))))))))..))))..).....(((((.....)))))........)))....))).))).....).))))......).)))))...)).)))..))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....(.(((.((.......)).))).)......))...)))))))))).))..(.(..((.(..((((.((....((((.(((.(((..(.((.((...((.((((((((((((..))))))))).).)).))...)).)).)..))).))).))))...)).))))...).))...)..)..(((((((((....)))))))))}........ Mammalian 80S ribosome bound with the ALS/FTD-associated dipeptide repeat protein poly-PR; 18S rRNA 7toq A25S 3649 3.1 RF02540,RF02543 URS00023359A5_9986 35589706 0003735 0005840 9986 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcgcgguccggccgugucggcggcccggcggaucucccgcucccgucggcgggggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggccccggcggggaagguggcccgggggccccggguguuacagccccgccccggcagcagcagcucgccgaaucccggggccgagggagcgagacccgugcgccgcgcucuccccccucgggggggccgggccaccccucccacggcgcgaccgcuggggcggacuguccagugcgccccgggcgggucgcgccgucgggcccggggggccacgcgucccccgcgagcgcacggggucggcggcgaugucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggcaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucuccgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcugguguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggaugguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucggcagagcgagaaagagaguggcgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcugggucggucgcggccggcgccuagcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacaugagagguguagaauaagugggaggccggccgccggugaaauaccacuacucugaucguuuuuucacugacccggugaggcgggggggcgagccccgaggggcucucgcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccggagccucgguuggccucggauagccggucccccgcgggguccggugcggagagcccuucgucccgggaaacggggcggccggaaagggggccgcccucucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<<....<......>.....>>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..[[[...<<<<...<<<<<<<<<<<...>>>>>>>.>>>>.....>>>>...<<<<<<<<<....<<<<<<<<.<......<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>..>>>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<......>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<<....<<<<<<<.<<<<<.<<....<<<<.<<<<<<<<<......>>>>>>>>>>>>>>>>>.>>>>>>>...>>>.>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<<<<<<<<<<<<<<<<<...<<..<<<..<<<<<<<......<<<<<<<<.>>>>>>>>.......>>>>>>>..>>>.........>>>>>>..>>>>>>>>>>>.....<<.......>>.........<...<<<<<<..>>>>>>....<<<...<<.<<<<<<<<<<<<<<<<<<<<<<<.<<<<..>>>>.>>>>>>.>>>.>>>>>>>>>>>.>>>...>>.>>.>................>........>>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<<....>>>>>>>>..<<<<<...<<<..<<.{.[[..>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<<<...<<<....<<<..<.<<<..<<<<.<.<.....>.>.>>>>>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>>>>>>.>>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<.....................>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<....................]].}..............>>>>>>>>>....>>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<<....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<<<<<...>>>>>>>>>>>......>>....>>...<<<<<........>>>>>))<<<<....<<<<...<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<<<<<<<<<<<<..{{{..>>>>>>.....<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>......<<<<<<<.......>>>>>>>>>>>.>.>>>>>>>>>>>>.........>>>>>>>..>..........>..>>>.>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<...............<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<...<<<<<..>>>>>........>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>...>>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<<.<<<<<<<<<<<<.<<<<..........<<<<<..<<<..>>>............>>>>>.>>>>.>>.>>>>>>>>>>...<<<<<.....<<<<..<<.<.<<<<....>>>>.>>>..............<<<<<<<<<<<.....>>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>>.<<<....>>>.>>))).......((((((..(((..>>>>>>.)))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.........<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.<.....>.>>>.....>>>>>..>...>>>.......<<<<<<<....>>>.>>>>....}}..}}}.]]]]].....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<}}}.>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>......<<<<<<...<<<<....<<<........<<<<<..<<<<..>>>>.>>>>>.......>>>...<<<..<<<<....<<<<<<<<<........>>>>>>.>>>...>>>>..>>>..............>>>>....>>>>>>.<<<<<.<.............>....<<.<<<<<<<.<<.....<<<<....<<<<<......>>>>>...>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..(((((((((((.....)))))).))))....))))....(((((((((....((((((((.(......((((((((..({((((......)))))....[[(...).(((....}]])))...).)))))))..)))))))))...)))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...(((((((..(((.....((((((((((.(..(((((((.(((((.((....((((.((.(((((.(.()..)))))).)))))))))).)))))))...))))))))))))))......)))..)).)))))....((((((((((((((((((((((...((..(((..(((((((.......(((((((.)))))))........)))))))..))).........))))))..))))))))))).....((.....{.)).........(.(.((((((()))))))....(((...((.(((((((((((((((((((((((.((((..)))).)))))).))).))))))))))).)))...).))).)..............).)........))).))))....)))))...)))))))).[((((........))))((((((....(((((((((((((..(((..(((((........)))).)...)))...((....))...((((((((....))))))))..(((((...(((..(..[.[[[..)..)))....))))).(((((((((.((((......))))))))))).))....)))))))))))))..((.(...((((((.....(((((((((..((.(...(((((((....)))))))...)<.))...(((..((.((.......A)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((...(((.((((((((....(((....(((..(.(((..(((((..(.....)..)))))))).)..)))..)).)....))))))...(((((((((.(......))))))))))....))))))))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[.....(.(((((......(..........(((.((((((((((.......(((((..((....(.........)....))......(...((......)).).)))))...)))))))))))))..........]]].)....)))))).)))...)))))))((((((.(((........}.........].]].]..............)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...((..(.(((....))).....)....((.((((.(.((...)).).))))))......))....))...(((((........)))))]]((((....(((.....(((((((....)))))))...(((....)))...(...((((((...(((((((((((((((((((((((..{{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...).............))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((...(((((())))))........)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.....((.....((((....)))).....))..))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.(((((((((.(((((..((....((((...........((((..(((..)))............))))..)))).....))..)))))...(((((.....((((..(..((((((....)))))).)..............(((((((((((.....)))))))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(.(((.(((((....{..)))).)))))(((....))).))]]].......((.(((..(((..]]]]]].)))))).))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a.))..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}}.)))))..)).))...))))...)))).((((...((((.............))))...))))..)))...).))))))......(((((.....(((....(((.........((((...(((())))..))))........)))...(((..(((.....((..(((((........)))))...))....)))..)))..............)))......))))).(((((.(..(.......)..)....((.(((((((.((.....((((.(..(((((......)))))..)))))....))....)))).))).))..))))).. Mammalian 80S ribosome bound with the ALS/FTD-associated dipeptide repeat protein poly-PR; 28S rRNA 7toq A58S 156 3.1 RF00002 URS00004B2C76_9986 35589706 0003735 0005840 9986 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<.<<.....>>>.....(.<<<......>>.............>>>..)...>>>....<<<..>>><<<<<<<<.......>>>>>>>>.................... .........................................((((((.[[....[)))...].(.(((......]].............)))..)...)))....((....))((((((((.......)))))))).................... Mammalian 80S ribosome bound with the ALS/FTD-associated dipeptide repeat protein poly-PR; 5.8S rRNA 7toq A5S 120 3.1 RF00001 URS000002B0D5_9986 35589706 0003735 0005840 9986 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<<............>>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. Mammalian 80S ribosome bound with the ALS/FTD-associated dipeptide repeat protein poly-PR; 5S rRNA 7toq MRNA 10 3.1 URS00023359A7_4932 35589706 4932 cacauguucc .......... .......... Mammalian 80S ribosome bound with the ALS/FTD-associated dipeptide repeat protein poly-PR; RNA (5'-R(*CP*AP*CP*AP*UP*GP*UP*UP*CP*C)-3') 7toq PTRN 77 3.1 RF00005 URS000041AF00_83333 35589706 0030533 0006412 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Mammalian 80S ribosome bound with the ALS/FTD-associated dipeptide repeat protein poly-PR; tRNAfMet 7tor A18S 1691 2.9 RF01960,RF01959,RF00177 URS0000EEACFB_9986 35589706 0003735 0005840 9986 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucgacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgcggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcggccguccccugcucggcgccggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgaccccggucggcguaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccgggccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<....<<....<<<..........<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<<<....>>>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<.>>>>>>>....>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....<<<<<<<<<.<<<....>>>..>>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<....<<<.<<<..>>>.>>><<<<<<<.<<..>>>>>>.>>>.<<<<<<.<.......<<...<.......>.<<<<.>>>>...>>......>.>>>..>>>........<.<<.<<<<<<<...............>>>>>>>.>>.>....>>....<<<<<<..<...<<<<..<<<.<<<<<<<<...<<<......>>>......>>>>>>>>.>>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<..>>>>.>>>>>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<.<<<<<<<..>>>>>>>...>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..((....(((.....((...((.....((.(((.....))).))......))......)).((((...((((((....))))))...))))((..(((((...(......)..)))))......)).(.((((..((.)).)))))...)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.(((......)))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).).....(((((((((.(((....)))..)))))).)))....(.((..(...........)..))......)..((((([[......((((.....((..]])).......)))).)))))..)))))).)))..[......(.([[...(.(.((...(((.((....(((..((()))..))).((((((.((())))))).))..((((((.(.......((..((.......)).(((.)))....))......).)))..)))........(.((.(((((((...............))))))).)).)....))...((...(...(...((((..((..((((((((...((........))......))))))))..)).......((....))...))))..)...)....)..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.((.((....)).)))))))).)..)))...((..]]))...))...].))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((..((........))..))....).)))))....(.((....(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((...(...((((..((((((((((((..)))).))))))))..))))..).....(((((.....)))))........)))....))).))).....)..)))......).)))))...)).)))).))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....(.(((.((.......)).))).)......))...)))))))))).))..(.(..((.(..((((.((..(..((((((..(((..((((.((...(((((((((((.(()).))))).).)))))...)).))))..)))..)))))).)..)).))))...).))...)..)..(((((((((....)))))))))}........ Mammalian 80S ribosome bound with the ALS/FTD-associated dipeptide repeat protein GR20; 18S rRNA 7tor A28S 3552 2.9 RF02540,RF02543 URS00023359A6_9986 35589706 0003735 0005840 9986 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggaaauguggcguacggaagacccacuccccggcgcgggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcgcgguccggccgugccggcggggcggauccccgcucucggcgggggaccgccccccggccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggccccggcggggaagguggcccgggggccccggguguuacagccccgccccggcagcagcagcucgccgaaucccggggccgagggagcgagacccgugcgccgcgcucuccccccggggggccgggccaccccucccacggcgcgaccgcuggggcggacuguccagugcgccccgggcgggucgcgccgucgggcccggggggccacgcguccagcgcacggggucggcggcgaugucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcuacgaaagccgccguggcgcaaugaaggugaaggccggccggccgaggugggaucccgaggcaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcgaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccaaaguuucccucaggauagcuggcgcucuccgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcugguguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggaugguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgcuggcagucggcagagcgagaaagagagggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucagccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcucagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacaugagagguguagaauaagugggaggccggccgccggugaaauaccacuacucugaucguuuuuucacugacccggugaggcgggggggcgagggcucucgcuucuggcgccaagcgcccggcgccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauagccggagccucgguuggccucggauagccggucccccggggguccggugcggagagcccuucgucccgggaaacggggcggccggaaagggggccgcccucucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcaggcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<...<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>...<<<<<<<<<....<<<<<<<<<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>...>>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<.<....<<<<<<<<.<<<.....<<<<<<<<<<....<<<<<<<.<<<<<.<<<<<<<.<<<<<<<.....>>>>>.>>>>>>>>>>>>>>>>>>...>>>.>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<.<<<<<<<<<<<<<<<...<<..<<<..<<<<<<<......<<<<<<<...>>>>>>>.......>>>>>>>..>>>.........>>>>>>..>>>>>>>>>>>.....<<.......>>.........<...<<<<<.>>>>>....<<<...<<.<<<<<<<<<<<<<<<<<<<<<<<.<<<<..>>>>.>>>>>>.>>>.>>>>>>>>>>>.>>>...>>..>>>..........>.........>>.>>>>>....>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<.....>>>>.....>>>...<<....>>...<<<<<..>>>>>..<<<<<...<<<..<<...[[..>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<<<...<<<....<<<..<.<<<..<<<<.<.........>.>>>>>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>>>>>>.>>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...................>>>......................>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<....................]]..........>>>>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<<<<<...>>>>>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<..<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<...............<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<.>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<<<<<<.<<<<...........<<<<..<<<..>>>............>>>>..>>>>.>>.>>>>>>>>>>...<<<<<.....<<<<..<<.<<....>>>>..............<<<<<<<<..>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>><<<<....>>>>>>)))......<<<<<<<..<<<..)))))).>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<]]].>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.<<<<<..<<<<....<<<........<<<<<..<<<<.>>>>.>>>>>.......>>>...<<<..<<<<....<<<<<<<<<........>>>>>>.>>>...>>>>..>>>..............>>>>..>.>>>>...<<<<<.<.............>....<<.<<<<<<<.<<.....<<<<....<<<<.>>>>...>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..(((((((((((.....)))))).))))....))))....(((((((((....(((.((((((((((((..({((((......)))))....[[(...).(((....}]])))...).)))))))...)))).)))...)))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....((((((((((.(..(((((((.(((((.(((((((.(((((((.(..)))))).))))))))))))))))))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((..(((((((.......((((((...))))))........)))))))..))).........))))))..))))))))))).....((.....{.)).............(((((.)))))....(((...((.(((((((((((((((((((((((.((((..)))).)))))).))).))))))))))).)))...).).)))...................))).)))))...)))))...)))))))).[((((........))))((((((....(((((((((((((..(((..(((((.....))))..)..)))...((....))...(((((())))))..(((((...(((..(((..[[[)))..)))....))))).(((((((((.((((......))))))))))).))....)))))))))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)<)))...(((..((.((.......B)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((...(((.((((((((....(((....(((..(.(((..(((..(..........).)))))).)..)))..)).)....))))))...(((((((((.(......))))))))))....))))))))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[.....(.(((((......(..........(((.((((((((((.....A.(((((..((...................))......(..............).)))))...)))))))))))))..........]]].)....)))))).)))...)))))))((((((.(((........}.........].]]..........)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...((..(.(((....))).....)....((.((((..(((...)))..))))))......))....))...(((((........)))))]]((((....(((((...(((((((....)))))))..((((....)))...(...((((((...(((((((((((((((((((((((...{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.((((((((((.))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.....((.....((((....)))).....))..))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.(((((((((.(((((.((...(.((((.............((..(((..)))............))....)))).)....)).)))))...(((((.....((((..(..((....)).)..............((((((((()))))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..b.))..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}..)))))..)).))...))))...)))).((((...((((.....a.......))))...))))..)))...).)))))).(((....((((....(((.........((((.(.(((.)))).))))........)))...(((..(((.....((..(((((........)))))...))....)))..)))..............)))).....)))...(((((.(..(.......)..)....((.(((((((.((.....((((.(..((((.))))..)))))....))....)))).))).))..))))).. Mammalian 80S ribosome bound with the ALS/FTD-associated dipeptide repeat protein GR20; 28S rRNA 7tor A58S 151 2.9 RF00002 URS0000D56C3A_9986 35589706 0003735 0005840 9986 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcagguugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<<<<....>>>>.....<.<<<......>>........>>>..>...>>>....<<<..>>><<<<<<<<.......>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]]........)))..)...)))....((....))((((((((.......)))))))).................... Mammalian 80S ribosome bound with the ALS/FTD-associated dipeptide repeat protein GR20; 5.8S rRNA 7tor A5S 120 2.9 RF00001 URS000002B0D5_9986 35589706 0003735 0005840 9986 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. Mammalian 80S ribosome bound with the ALS/FTD-associated dipeptide repeat protein GR20; 5S rRNA 7tor ETRN 77 2.9 RF00005 URS000041AF00_83333 35589706 0030533 0006412 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(.(((..]....))).)))))))..... Mammalian 80S ribosome bound with the ALS/FTD-associated dipeptide repeat protein GR20; tRNAfMet bound to E-site 7tor MRNA 10 2.9 URS00023359A7_4932 35589706 4932 cacauguucc .......... .......... Mammalian 80S ribosome bound with the ALS/FTD-associated dipeptide repeat protein GR20; mRNA 7tor PTRN 74 2.9 RF00005 URS000041AF00_83333 35589706 0030533 0006412 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaa .<..<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>..>.. .....((..((.(......[..).)).(((((.......))))).....(((((..]....)))))))...... Mammalian 80S ribosome bound with the ALS/FTD-associated dipeptide repeat protein GR20; tRNAfMet bound to E-site 7tos 16S 1532 2.9 RF00177,RF01959,RF01960 URS000080DDC0_562 35589706 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggauc .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<.<<....>>.>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((............))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..(......))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....))))))).............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... E. coli 70S ribosomes bound with the ALS/FTD-associated dipeptide repeat protein PR20; 16S ribosomal RNA 7tos 23S 2903 2.9 RF02540,RF02541 URS0000BC4674_562 35589706 0003735 0005840 562 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<<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<<..>>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>...>.>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<......<.<<<<<.<<...<<<.........>>>...>>........<<<......>>>..>>>>>.>..>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<.<......>.>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<....<<..>>.....>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<<.<<....>>..>>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<..<<........<<<<<<......>>>>>>.....>>............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((.(((.(((...(((((......)))))[[......(((.....]])))...)))...))).)))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((.((((.....))))..))...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((.(......).))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((((((((..((..............(..(...(........((..((......))..)).....).............)..).....))..))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). E. coli 70S ribosomes bound with the ALS/FTD-associated dipeptide repeat protein PR20; 23S ribosomal RNA 7tos 5S 120 2.9 RF00001 URS00008116C5_562 35589706 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((.(((((...))))).)).......))...)))))))))). E. coli 70S ribosomes bound with the ALS/FTD-associated dipeptide repeat protein PR20; 5S ribosomal RNA 7tql 2 1656 3.2 RF01960,RF01959,RF00177 URS00023358E1_9606 35732735 0003735 0005840 9606 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucguacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgccggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucucuagcguuuacuuugaaaaaauuagaguguucaaagcaggccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgaccggucggcguaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcguguccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggugcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<....<<....<<<<<.........<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<<<....>>>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<..>>>>>>>.>>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....<<<....<<.<<<....>>>..>>.....>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<...<..>...<<<<<<.<.......<<...<.......>..<<<.>>>....>>......>.>>>..>>>........<.<<.<<<<<<<...............>>>>>>>.>>.>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<<....>>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<.<......<<........>>..........<<<<<......<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<..<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<..>>>.>>>>>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>.>.......>>>>>...>..>>>>.>>>.....<<.<<<........<.<<<.<<<<....>>>>.>>>....>.........>>>.>>............<<<<<..........>>>>>...........>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<<<<<<<<<<<..>>>>>>>>>.>.>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..((....((((.....([...((.....((.(((.....))).))......))......)..((((...((((((....))))))...))))((..(((((...(......)..)))))......)).(]((((.(((..)))))))).).)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).).....((((...((.(((....)))..))...).)))....(.((..(...........)..))......)..((((([[....(.((((.....((..]])).......))))))))))..)))))).)))..[......(.([[...(.(.((...(((......(())...((((((.(.......((..((.......)).(((.)))....))......).)))..)))........(.((.(.((((.................))).)).)).).........(((.((...(...((((..(((.((((((((...((........))......)))))))).))).......((....))...))))..)...))..))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.(((((....))))))))))).)..)))...((..]]))...))...].))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((.(..(((.(((((....)))..(.((......)))...)).)))....(((...(...((((..((.((((((((()))).))))).))..))))..).....(((((.....)))))........))).)..))).))).....).))))).....).)))))...)).)))).))).(...((.(((........(.(((.((((....)))).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(..(((((((.(((..((((.((...(((((((((((.(((..))).))))).).)))))...)).))))..))).))))))).)..)).))))...).))...)..)..(((((((((....)))))))))}........ CryoEM structure of the human 40S small ribosomal subunit in complex with translation initiation factors eIF1A and eIF5B.; 18S ribosomal RNA 7tql 3 75 3.2 RF00005 URS0000326EAC_9606 35732735 0030533 0006412 9606 agcagaguggcgcagcggaagcgugcugggcccauaacccagaggucgauggaucgaaaccauccucugcuacca <<<<<<<....<.........>...<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..................(((((.......))))).....((.((.......)).))))))))).... CryoEM structure of the human 40S small ribosomal subunit in complex with translation initiation factors eIF1A and eIF5B.; Human Met-tRNAiMet 7tqv G 33 3.43 URS0000CBFF1E_32630 35801916,35262076 32630 gguaguagguuguauaguaguaagaccagaccc ................................. ................................. SARS-CoV-2 endoribonuclease Nsp15 bound to dsRNA; RNA (33-MER) 7tqv H 33 3.43 URS0000CBFF4E_32630 35801916,35262076 32630 gggucuggucuuacuacuauacaaccuacuacc ................................. ................................. SARS-CoV-2 endoribonuclease Nsp15 bound to dsRNA; RNA (33-MER) 7ttu 1 2684 3.0 RF02540,RF02541,RF00002 URS00000AF0B7_1280 35736238 0003735 0005840 1280 uaaguuauuaagggcgcacgguggaugccuuggcacuagaagccgaugaaggacguuacuaacgacgauaugcuuuggggagcuguaaguaagcuuugauccagagauuuccgaauggggaaacccagcaugaguuaugucauguuaucgauaugugaauacauagcauaucagaaggcacacccggagaacugaaacaucuuaguacccggaggaagagaaagaaaauucgauucccuuaguagcggcgagcgaaacgggaagagcccaaaccaacguugggguuguaggacacucuaguuacaaaggacgacauuagacgaaucaucuggaaagaugaaucaaagaagguaauaauccuguagucgaaaauguugucucucuugaguggauccugaguacgacggagcacgugaaauuccgucggaaucugggaggaccaucuccuaaggcuaaauacucucuagugaccgauagugaaccaguaccgugagggaaaggugaaaagcaccccggaaggggagugaaauagaaccugaaaccgugugcuuacaaguagucagagcccguuaaugggugauggcgugccuuuuguagaaugaaccggcgaguuacgauuugaugcaagguuaagcaguaaauguggagccguagcgaaagcgagucugaauagggcguuuaguauuuggucguagacccgaaaccaggugaucuacccuuggucagguugaaguucagguaacacugaauggaggaccgaaccgacuuacguugaaaagugagcggaugaacugaggguagcggagaaauuccaaucgaaccuggagauagcugguucucuccgaaauagcuuuagggcuagccucaagugaugauuauuggagguagagcacuguuuggacgagcgaauucagacaaacuccgaaugccaauuaauuuaacuugggagucagaacaugggugauaagguccguguucgaaagggaaacagcccagaccaccagcuaaggucccaaaauauauguuaaguggaaaaggauguggcguugccacagagugacacugcgccgaaaauguaccggggcuaaacauauuaccgaagcuguggauugucgacaaugguaggagagcguucuaagggcguugaagcaugaucguaaggacauguggagcgcuuagaagugagaaugccggugugaguagcgaaagacgggugagaaucccguccaccgauugacuaagguuuccagaggaaggcucguccgcucuggguuagucggguccuaagcugaggccgacaggcguaggcgauggauaacagguugauauuccuguaccaccuauaaucguaucgauggggggacgcaguaggauaggcgaagcgugcgauuggauugcacgucuaagcaguaaggcgcugagcugugauggggagaagaccuucgagucguugauuucacacugccgagaaaagccucuagauagaaaauaggugcccguaccgcaaaccgacacagguagucaagaugagaauucuaaggugagcgagcgaacucucguuaaggaacucggcaaaaugaccccguaacuucgggagaaggggugcucuuuaggguuaacgcccagaagagccgcagugaauaggcccaagcgacuguuuaucaaaaacacaggucucugcuaaaccguaaggugauguauaggggcugacgccugcccggugcuggaagguuaagaggagugguuagcuucugcgaagcuacgaaucgaagccccaguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgacccgcacgaaaggcguaacgauuugggcacugucucaacgagagacucggugaaaucauaguaccugugaagaugcagguuacccgcgacaggacggaaagaccccguggagcuuuacuguagccugauauugaaauucggcuuucuaacccgcaccacuuaucguggugggagacagugucaggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcucaaagguucccucagaaugguuggaaaucauucauagaguguaaaggcauaagggagcuugacugcgagaccuacaagucgagcagggucgaaagacggacuuagugauccggugguuccgcauggaagggccaucgcucaacggauaaaagcuaccccggggauaacaggcuuaucucccccaagaguucacaucgacggggagguuuggcaccucgaugucggcucaucgcauccuggggcuguagucggucccaaggguugggcuguucgcccauuaaagcgguacgcgagcuggguucagaacgucgugagacaguucggucccuauccgucgugggcguaggaaauuugagaggagcuguccuuaguacgagaggaccgggauggacauaccucugguguaccaguugucgugccaacggcauagcuggguagcuauguguggacgggauaagugcugaaagcaucuaagcaugaagccccccucaagaugagauuucccaacuucgguuauaagaucccucaaagaugaugagguuaauagguucgagguggaagcauggugacauguggagcugacgaauacuaaucgaucgaagacuuaau <<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<.[...((.>>>.....<<<<<<<..<<.))...]..>>.....>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<<<<<<<<.........>>>>>>>.>>.>>....<<<<<......<<....>>.......>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..(((....<<<<..>>>>......<<<<<...............<.<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>..>.........>..>>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<......>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<.<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>.>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<...<<<<<<<<<.....<<<...<<<<<<<<........>>>>>>>>..>>.>.....>>>>.>>>>>..>>>>>>>.>>..<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<.<.<<........>>.>.>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<..>>>>>....>>>>>><.<<<<<<<.<<......<<<<<.<<....>>.>>>>>...>>.>>>>>>>..>.....>>>>>><......<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<........<<...<<<<....<<<<...<<...<......<<<.........>>>...<....<<<<...<<..>>...>>>>.....>...................>....>>...>>>>.........>>>>..>>.......>>>>>>>>>>..>>.....<<......>>>>>>>.<<<.......>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<....<<..>>.....>>>>><<<<<<<.<<<<....>>>>.>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<......>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<..<<...<<<<<<.<<....>>..>>>>>>...>>..>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>.>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<..<<<<......>>>>....<<.<<<<<<.....>>>>>>>>......>>>>>>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<....>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<....>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>.. .((((......((((((((((.....(((..((((((((.((((......((((((.[[..[[[)))...].((((((...(((]]..]].)))......))))))...)))....(((....)))(((((((......))))))).(((((.((...........)).))).)).))....(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...((.(().)))....[.((((................(..((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))))...)............)))))....(((((((...{.......)))))))....].(((((}.[[[[)))))..)))......))..)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((..((((..[...))))..)))).<.(.(........).).((((((....(((((((.(((((..(((...(((.....)))...)))...((....))...(((.....)))......))))).)))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...).)))...(((.(((((.......{))))))))..).))))))))).(.(((....[)))...).]))))))......).))..((((((....(((((....)))))(((((((((...((.(.((((.....(((...((((((((........))))))))..)).).....))))..).))..))))))).))..((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((.(.(((......))).).)))).))...........]]].)...))))))))))...)))))))(((((())))))....))))))(.(((((((.((......(((((.((....))])))))...)).)))))))..).....))))))(......((....((((((.......))))))((((....(((...((...((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((.........((...((((....((((...((..........(.............)...((....(((....(..)....))).....))........................))...))))(..).....))))..))........)))))))))..)).....((......))..))).(((.......)))..))))..((((....((((((((.((..(....(.......(((((....(.[..).....)))))(((((.(...((....))...).)))))(...).......(((((((((...((.........))...(((((((.....(((....))).......))))))).]((((..((..(((((((..(((...((...(((((..((....))...)))))...))...))))))))..)))).(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).[..(((((.....>].)))))..((((((((.(((..(......((((.((((((..(((((.(((((((((.(((........)))....((.((((((.....)))))))).....)))))))))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....((.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..))....(((((.(....).).))))..}.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((....))))))..)))))...)))).)))))...(((....((((.............))))....))).))))..]....))))))).(.(....).)....(((((((((.......)))))....((.(((((.(((.....((((....))))....)))..)))))..))...))))....))))... 50S ribosomal subunit from Staphylococcus aureus (Strain ATCC43300); 23S rRNA 7ttu 2 111 3.0 RF00001 URS00023359D0_1280 35736238 0003735 0005840 1280 cuggugacuauagcaaggaggucacaccuguucccaugccgaacacagaaguuaagcuccuuagcgucgaugguagucgaacuuacguuccgcuagaguagaacguugcaa ...<........<<<<<<<<.....<<<<<<.............>>>>..>>....>>>>>>.>>.<......<.<..<........>..>...>....>......>.... ............((((((((.......((((...(.....)...))))........)))))).))..........(..............).................... 50S ribosomal subunit from Staphylococcus aureus (Strain ATCC43300); 5S rRNA 7ttw 1 2690 2.9 RF02540,RF02541,RF00002 URS00000AF0B7_1280 35736238 0003735 0005840 1280 uaaguuauuaagggcgcacgguggaugccuuggcacuagaagccgaugaaggacguuacuaacgacgauaugcuuuggggagcuguaaguaagcuuugauccagagauuuccgaauggggaaacccagcaugaguuaugucauguuaucgauaugugaauacauagcauaucagaaggcacacccggagaacugaaacaucuuaguacccggaggaagagaaagaaaauucgauucccuuaguagcggcgagcgaaacgggaagagcccaaaccaacguugggguuguaggacacucuaguuacaaaggacgacauuagacgaaucaucuggaaagaugaaucaaagaagguaauaauccuguagucgaaaauguugucucucuugaguggauccugaguacgacggagcacgugaaauuccgucggaaucugggaggaccaucuccuaaggcuaaauacucucuagugaccgauagugaaccaguaccgugagggaaaggugaaaagcaccccggaaggggagugaaauagaaccugaaaccgugugcuuacaaguagucagagcccguuaaugggugauggcgugccuuuuguagaaugaaccggcgaguuacgauuugaugcaagguuaagcaguaaauguggagccguagcgaaagcgagucugaauagggcguuuaguauuuggucguagacccgaaaccaggugaucuacccuuggucagguugaaguucagguaacacugaauggaggaccgaaccgacuuacguugaaaagugagcggaugaacugaggguagcggagaaauuccaaucgaaccuggagauagcugguucucuccgaaauagcuuuagggcuagccucaagugaugauuauuggagguagagcacuguuuggacuucagacaaacuccgaaugccaauuaauuuaacuugggagucagaacaugggugauaagguccguguucgaaagggaaacagcccagaccaccagcuaaggucccaaaauauauguuaaguggaaaaggauguggcguugccacagagugacacugcgccgaaaauguaccggggcuaaacauauuaccgaagcuguggauuguccuuuggacaaugguaggagagcguucuaagggcguugaagcaugaucguaaggacauguggagcgcuuagaagugagaaugccggugugaguagcgaaagacgggugagaaucccguccaccgauugacuaagguuuccagaggaaggcucguccgcucuggguuagucggguccuaagcugaggccgacaggcguaggcgauggauaacagguugauauuccuguaccaccuauaaucguaucgauggggggacgcaguaggauaggcgaagcgugcgauuggauugcacgucuaagcaguaaggcugccgguagcugagcugugauggggagaagaccuucgagucguugauuucacacugccgagaaaagccucuagauagaaaauaggugcccguaccgcaaaccgacacagguagucaagaugagaauucuaaggugagcgagcgaacucucguuaaggaacucggcaaaaugaccccguaacuucgggagaaggggugcucuuuaggguuaacgcccagaagagccgcagugaauaggcccaagcgacuguuuaucaaaaacacaggucucugcuaaaccguaaggugauguauaggggcugacgccugcccggugcuggaagguuaagaggagugguuagcuucugcgaagcuacgaaucgaagccccaguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgacccgcacgaaaggcguaacgauuugggcacugucucaacgagagacucggugaaaucauaguaccugugaagaugcagguuacccgcgacaggacggaaagaccccguggagcuuuacuguagccugauauugaaauucggcuuucuaacccgcaccacuuaucguggugggagacagugucaggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcucaaagguucccucagaaugguuggaaaucauucauagaguguaaaggcauaagggagcuugacugcgagaccuacaagucgagcagggucgaaagacggacuuagugauccggugguuccgcauggaagggccaucgcucaacggauaaaagcuaccccggggauaacaggcuuaucucccccaagaguucacaucgacggggagguuuggcaccucgaugucggcucaucgcauccuggggcuguagucggucccaaggguugggcuguucgcccauuaaagcgguacgcgagcuggguucagaacgucgugagacaguucggucccuauccgucgugggcguaggaaauuugagaggagcuguccuuaguacgagaggaccgggauggacauaccucugguguaccaguugucgugccaacggcauagcuggguagcuauguguggacgggauaagugcugaaagcaucuaagcaugaagccccccucaagaugagauuucccaacuucgguuauaagaucccucaaagaugaugagguuaauagguucgagguggaagcauggugacauguggagcugacgaauacuaaucgaucgaagacuuaau 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.((((......((((((((((.....(((..((((((((.((((......((((((.[[..[[[)))...].((((((...(((]]..]].)))......))))))...)))....(((....)))(((((((......))))))).(((((.((...........)).))).)).))....(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...((((()))))....[.((((....(...........(..((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))))...).......)....)))))....(((((((...{.......)))))))....].(((((}.[[[[)))))..)))......))..)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((..((((..[...))))..)))).{.(.(........).).((((((....(((((((.(((((..(((...(((.....)))...)))...((....))...(((.....)))......))))).)))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...).)))...(((.(((((.......<))))))))..).))))))))).(.(((....[)))...).]))))))......).))..((((((....(((((....)))))(((((((((...((.((((((.....(((...((((((((.))))))))..)).).....)))).)).))..))))))).))..((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((.(((((......))))).)))).))...........]]].)...))))))))))...)))))))((((((.....))))))....))))))(.(((((((.((......(((((.((....))])))))...)).)))))))..).....))))))(......((....((((((.......))))))((((....(((...((...((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((..(....((...((((....(((((..((...(........................(.....(((....((........))....)))......)...................)....))..)))))(..).....))))..))..)...)))))))))))..)).....((......))..))).(((.......)))..))))..((((....((((((((.((..(....(.......(((((....(.[..).....)))))(((((.....((....)).....)))))(...).......(((((((((...((.........))...(((((((.....(((....))).......))))))).]((((..((..(((((((..(((...((...(((((..((....))...)))))...))...))))))))..)))).(.(((.........))).)........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).[..(((((.....}].)))))..((((((((.(((..(......((((.((((((..(((((.(((((((((.(((..(..)..)))....((.((((((.....)))))))).....)))))))))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..)))))).......((((.(.((((((...((.......))...))))))...)))).)........(.((..(((((..(((((((((......))))))..))).(((((.....))))).....)))))......))..).....(((((.(....).).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((....))))))..)))))...)))).)))))...(((....((((.............))))....))).))))..]....))))))).(.(....).)....(((((((((.......)))))....((.(((((.(((....(((((....)))))...)))..)))))..))...))))....))))... 50S ribosomal subunit from Staphylococcus aureus containing double mutation in uL3 imparting linezolid resistance; 23S rRNA 7ttw 2 111 2.9 RF00001 URS00023359D0_1280 35736238 0003735 0005840 1280 cuggugacuauagcaaggaggucacaccuguucccaugccgaacacagaaguuaagcuccuuagcgucgaugguagucgaacuuacguuccgcuagaguagaacguugcaa .<<<........<<<<<<<......<<<<<...............>>>..>>.....>>>>>.>>.<...<..<.<..<........>..>...>.>..>......>.>>. ............((((((........(((((...(.....)...))))..).......)))).))..........(..............).................... 50S ribosomal subunit from Staphylococcus aureus containing double mutation in uL3 imparting linezolid resistance; 5S rRNA 7tut q 76 3.88 RF00005 URS0002617744_9986 36261528 0030533 9986 gucuccguaguguagcgguuaucacguucgccuaacacgcgaaagguccucgguucgaaaccgggcggaaacacca <<.<<<<..<<<..........>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>.>>.... ((.((((..(((.....[....))).(((((.......))))).....(((((..]....))))))))).)).... Structure of the rabbit 80S ribosome stalled on a 4-TMD Rhodopsin intermediate in complex with the multipass translocon; P-site tRNA 7tut u 120 3.88 RF00001 URS000002B0D5_9986 36261528 0003735 0005840 9986 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. Structure of the rabbit 80S ribosome stalled on a 4-TMD Rhodopsin intermediate in complex with the multipass translocon; 5S ribosomal RNA 7tut v 156 3.88 RF00002,RF02540 URS00004B2C76_9986 36261528 0003735 0005840 9986 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<<<<....>>>>.....<.<<<......>>.............>>>..>...>>>....<<<..>>><<<<<<<<.......>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))((((((((.......)))))))).................... Structure of the rabbit 80S ribosome stalled on a 4-TMD Rhodopsin intermediate in complex with the multipass translocon; 5.8S ribosomal RNA 7tut K 3543 3.88 RF02543 URS0000A7632C_9986 36261528 0003735 0005840 9986 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggaaauguggcguacggaagacccacuccccggcgccggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcgcgguccggccgugccggcggggcggaucucccgcucccgucggcgggggaccgccccccggccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggccccggcggggaagguggcccgggggccccggguguuacagccccgccccggcagcagcagcucgccgaaucccggggccgagggagcgagacccgugcgccgcgcucuccccccucgggggggccgggccaccccucccacggcgcgaccgcuggggcggacuguccagugcgccccgggcgggucgcgccgucgggcccggggggccacgcgucccccgcgagcgcacggggucggcggcgaugucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcuacgaaagccgccguggcgcaaugaaggugaaggccggcggcgcgccgccggccgaggugggaucccgaggccuuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcgaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccaaaguuucccucaggauagcuggcgcucuccgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcugguguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggaugguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgcuggcagucggcagagcgagaaagagaguggcgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucagccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcuggcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacguuuuuucacugacccggugaggcgggggggcgagccgggcucucgcuucuggcgccaagcgcccggccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauagcgccggagccucgguuggccucggauagccggucccccgccgggguccggugcggagagcccuucgucccgggaaacggggcggccggaaagggggccgcccucucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcugcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..[[[..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>>..<<<<<<<<<....<<<<<<<<..<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>...>>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<.<....<<<<<<<<.<<<.....<<<<<<<<<<....<<<<<<<.<<<<<.<<<<<<<.<<<<<<<<<......>>>>>>>>>>>>>>>>>>>>>>>>>...>>>.>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<<<<<<<<<<<<<<<<<...<<..<<<..<<<<<<<......<<<<<<<...>>>>>>>.......>>>>>>>..>>>.........>>>>>>..>>>>>>>>>>>.....<<.......>>.........<...<<<<<<..>>>>>>...<.<<...<<.<<<<<<<<<<<<<<<<<<<<<<<.<<<<..>>>>.>>>>>>.>>>.>>>>>>>>>>>.>>>...>>.>>.>................>........>>>.>>>>>....>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<.....>>>>.....>>>...<<....>>...<<<<<<<<<<..>>>>>>>>>>..<<<<<...<<<..<<<....[[.[[.>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<<<...<<<....<<<..<.<<<..<<.<.<.<.....>.>.>.>>>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>>>>>>.>>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<........>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<....................]].]].............>>>>>>>>>....>>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<<<<<...>>>>>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<..<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..{{{..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<.<<<<<<<<<<<.>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<<.<<<<<<<<<..>>>>>>>>>...<<<<<.....<<<<..<<.<.<<..>.>>.>>..............<<<<<<<<<..>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>><<<<....>>>>>>)))]......((((((..(((..>>>>>>.)))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]].....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<}}}.>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.<<<<<<...<<<<....<<<........<<<<<..<<<<<.>>>>>.>>>>>.......>>>...<<<..<<<<....<<<<<<<<<........>>>>>>.>>>...>>>>..>>>..............>>>>....>>>>>>.<<<<<.<.............>....<<.<<<<<<<.<<.....<<<<....<<<<<.>>>>>...>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..(((((((((((.....)))))).))))....))))....(((((((((.....(((.(((.(((((((((..({((((......)))))....[[(...).(((....}]])))...).)))))))..)))).)))....)))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....((((((((((.(..(((((((.(((((.(((((((.((.(((.((......)).))).))))))))))))))))))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((..(((((((......((((((((.)))))))).......)))))))..))).........))))))..))))))))))).....((.....{.)).........(...((((((..))))))...(.((...((.((((((((((((((.((((((((.((((..)))).)))))).))..))))))))))).)))...)).)).)............[...)........))).)))))...)))))...)))))))).<((((........))))((((((....(((((((((((((..(((..(((((.....))))..)..)))...((....))...((((((((((..))))))))))..(((((...(((..(((]...[[.[[[)))..)))....))))).(((((((((.((((......))))))))))).))....)))))))))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)<)))...(((..((.((........)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((...(((.(((((.((....(((....(((..(.(((..((.((..(.....)..)).))))).)..)))..)).)....)).)))...(((((((((.(......))))))))))....))))))))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[.....(.(((((......(..........(((.((((((((((.....A...(....(.....................)...........(......)......).....)))))))))))))..........]]].)....)))))).)))...)))))))((((((.(((........}.........].]].]].............)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...((....(((....)))..........((.((((.((((...)))).))))))......))....))...(((((........)))))]]((((....(((((...(((((((....)))))))..((((....)))...(...((((((...(((((((((((((((((((((((...{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((.)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(..(((.....((((....)))).....))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.(((((((((.(((((.(((()))).)))))...(((((.....((((..((....(..)....))..............(((((((((())))))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((.(.(..(((((...((.......))...)))))....)).).)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))....))..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}..)))))..)).))...))))...)))).((((...((((.....a.......))))...))))..)))...).)))))).(((((((..((((....(((.........((((...((((.))))..))))........)))...(((..(((.....(((..((((........))))...)))....)))..)))..............))))..).)))))).(((((.(..(.......)..)....((.(((((((.((.....((((.(..(((((.)))))..)))))....))....)))).))).))..))))).. Structure of the rabbit 80S ribosome stalled on a 4-TMD Rhodopsin intermediate in complex with the multipass translocon; 28S ribosomal RNA 7tzr X 80 2.7 RF00059 URS000080DDEB_562 35561226 0030976 562 ngacucggggugcccuucugcgugaaggcugagaaauacccguaucaccugaucuggauaaugccagcguagggaaguun <<<<<<<<<..<<.<<<<.....>>>>>>.........>>>>.....<<<...<<<<......>>>>...>>>..>>>>> (((((((((.((((.(((.....))))))......)..)))).....(((...((((......))))...)))..))))) Crystal structure of the E. coli thiM riboswitch bound to N-methyl-1-(quinoxalin-6-yl)methanamine (compound 16); RNA (80-MER) 7tzr Y 80 2.7 RF00059 URS000080DDEB_562 35561226 0030976 562 ngacucggggugcccuucugcgugaaggcugagaaauacccguaucaccugaucuggauaaugccagcguagggaaguun <<<<<<<<<..<<<.<<<.....>>>>>>.........>>>>.....<<<...<<<<......>>>>...>>>..>>>>> (((((((((.((((.(((.....))))))......)..)))).....(((...((((......))))...)))..))))) Crystal structure of the E. coli thiM riboswitch bound to N-methyl-1-(quinoxalin-6-yl)methanamine (compound 16); RNA (80-MER) 7tzs X 80 2.21 RF00059 URS000080DDEB_562 35561226 0030976 562 ngacucggggugcccuucugcgugaaggcugagaaauacccguaucaccugaucuggauaaugccagcguagggaaguun <<<<<<<<<..<<.<<<<.....>>>>>>.........>>>>.....<<<...<<<<......>>>>...>>>..>>>>> (((((((((.((((.(((.....))))))......)..)))).....(((...((((......))))...)))..))))) Crystal structure of the E. coli thiM riboswitch in complex with quinoxalin-6-ylmethanamine (compound 17); RNA (80-MER) 7tzs Y 80 2.21 RF00059 URS000080DDEB_562 35561226 0030976 562 ngacucggggugcccuucugcgugaaggcugagaaauacccguaucaccugaucuggauaaugccagcguagggaaguun <<<<<<<<<..<<<.<<<.....>>>>>>.........>>>>.....<<<...<<<<......>>>>...>>>..>>>>> (((((((((.((((.(((.....))))))......)..)))).....(((...((((......))))...)))..))))) Crystal structure of the E. coli thiM riboswitch in complex with quinoxalin-6-ylmethanamine (compound 17); RNA (80-MER) 7u0h 1 2722 2.76 RF02543 URS000061F377_1247190 36482249 0003735 0005840 1247190 guuugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaugguguuuugugcccucugcuccuuguggguaggggaaucucgcauuucacugggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaaacuuuaaauauguaaaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguuggaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguagugagggccuuggucagacguagacggccuuggugucgcuugcuacaauuaacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucgauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggcccuguugagcuuuuagucccucggaauuugaggcuagaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauugaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaagcuggaccgucgugagacagguuaguuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ..........................<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..<<<...........<<.<<<<<<...>>>>>>.>>.............<<<<<<.<<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>>..>>>>>>>....>>>>>>>>>>>........<<<<<<<.<....>.>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<......<<<<....<<..<<<<<<.<........>>>>>>>......>>....>>>>..<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<....<.<<<<<......>>>>>>......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<.<....>.>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>>.>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>>.....>.>>..<<<<<<....<.<<......>>.><<<<<<<<<<...<<<.<<<<<<.........................>>>>>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.....>>>>>>>>>....>>>>>><.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<<....<<<....>>>...<...<<<<<<...<<<<.<<<<<<<<<<<<<<<<<<..[[[..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<<....>>>>>>>>>>>>.>.>>>>>>>.>>>>.........>>>>>>...>.....>>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<...............>>>>><<.<<<<<<<<<<<..<<<<<<<.................................>>>>>>>.......>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>....<..>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<<<<<<<.<<<<<<<<<...<<<<.))))))>>>>.>>>>>>>>.>.>>>>>>..............<<<<<...<<.......>>...>>>>>.........((....<<<..<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.....))..>>>.....>>>>>.>>>.<<<<<<<....>>>.>>>>.......>>>.>>>>>....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<....<<<<<<<<<<]]].>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<<<.............>.....<<<<<<<<<.<<<....<<<<.<..<<<<<......>>>>>..>>>>>...>>>....>>>>.>>>>>.>>>>>>.. ..........................(((((......(......).......)))).).........((....))...((((......((.....)).....))))...((((.........(((.((((((...)))))).))....)........((((((..((((.((.((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..)))).)).....)))).))))))...)....(((((((.(....).))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.(((((......((((.........(.((.(..((.).).).)).).............))))..(((((((((((((((((((((((.......(((((((......(((((.).....)))).......))))))).....))))).))))))))))........(((....)))....)))))))).....))))).)))))..((((........))))((((((....((((((.((((((..(((..((((.......))))..)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((........)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.((((((........(........).......))))))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.....)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...((((((...((.....)).))))))....[[(((.((...((....(((....)))........((((((........))))))....))....))...(((((........)))))]]((((..(((((((...((((....)))...(...((((((...((((.((((((((((((((((((..{{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((((...((((.((.........(...........)...........)).))))........))))..)))))).))(...).......(((((((((.].((.........))...(((((((....(((.......)))......))))))).}..(())....)).))))))).)..))).)))))))..))))))....)).[..(((((......].)))))....(((((..(((((((((.((.((.(.(...((((.]]]]]])))).).).)).).).))))))..............((.((...((.......))...)).)).........[[...(((...(((((..(.(((((((......))))))..).).(((.....]]..))).....)))))..)))(((((((....))).)))).......))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}}.)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(((((......)))))..)))))...)))....)))).)))))).))))).. State NE1 nucleolar 60S ribosome biogenesis intermediate - Overall model; 25S rRNA 7u0h 2 158 2.76 RF00002 URS00001BF64E_1247190 36482249 0003735 0005840 1247190 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... State NE1 nucleolar 60S ribosome biogenesis intermediate - Overall model; 5.8S rRNA 7u0h 6 59 2.76 URS000261775E_1247190 36482249 1247190 ccuucucaaacauucuguuugguagugagugauacugaguuaacuugaaauugcuuaaa ......<<<<<<...>>>>>>.....<<<<.<.<<<.>>>>.>>>>............. ......((((((...))))))....(((((...(((.)))..))))..).......... State NE1 nucleolar 60S ribosome biogenesis intermediate - Overall model; ITS2 rRNA 7u2h 1A 2871 2.55 RF02540,RF02541,RF00002 URS00001698E8_300852 35766409 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<.....<<<........>>>......>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..<<.........>>...>>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<.......<<<<<<<....>>>>>>>....>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<...>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((..(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...((((((((....(((.(......).)..))...))))))))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((..((.........))...))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((.((((((((.(.........(((((..(((.......((((.((....)).))))....)))............)))))).)))))))).)))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..(((...)))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Gly-NH-tRNAgly, aminoacylated P-site fMet-NH-tRNAmet, and deacylated E-site tRNAgly at 2.55A resolution; 23S Ribosomal RNA 7u2h 1B 120 2.55 RF00001 URS000080DEE8_300852 35766409 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> (((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).))))))))))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Gly-NH-tRNAgly, aminoacylated P-site fMet-NH-tRNAmet, and deacylated E-site tRNAgly at 2.55A resolution; 5S Ribosomal RNA 7u2h 1a 1500 2.55 RF00177,RF01959,RF01960 URS000080DFED_300852 35766409 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>...<<<......>>>...>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((((((....))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((..((((....))))..))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((.(((....))).)))...((((....))))...)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Gly-NH-tRNAgly, aminoacylated P-site fMet-NH-tRNAmet, and deacylated E-site tRNAgly at 2.55A resolution; 16S Ribosomal RNA 7u2h 1v 13 2.55 35766409 10665 aaaaaugggguaa ............. ............. Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Gly-NH-tRNAgly, aminoacylated P-site fMet-NH-tRNAmet, and deacylated E-site tRNAgly at 2.55A resolution; MG-mRNA 7u2h 1w 73 2.55 RF00005 URS00003845FE_562 35766409 0030533 0006412 562 gcgggcgnaguucaagguagaacgagagcuucccaagcucuauacgagggnucgauucccuucgcccgcuccn <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[..)))).(((((.......))))).....((((..]....)))).))))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Gly-NH-tRNAgly, aminoacylated P-site fMet-NH-tRNAmet, and deacylated E-site tRNAgly at 2.55A resolution; A-site Aminoacyl-tRNA Gly-NH-tRNAgly 7u2h 1x 77 2.55 RF00005 URS000041AF00_562 35766409 0030533 0006412 562 cgcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaaccn .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Gly-NH-tRNAgly, aminoacylated P-site fMet-NH-tRNAmet, and deacylated E-site tRNAgly at 2.55A resolution; P-site Aminoacyl-tRNA fMet-NH-tRNAmet 7u2h 1y 73 2.55 RF00005 URS00003845FE_562 35766409 0030533 0006412 562 gcgggcgnaguucaagguagaacgagagcuucccaagcucuauacgagggnucgauucccuucgcccgcucca <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>....<<<<<.......>>>>>>>>>>>>.... (((((((..((((......)))).(((((.......)))))....(((((.......)))))))))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Gly-NH-tRNAgly, aminoacylated P-site fMet-NH-tRNAmet, and deacylated E-site tRNAgly at 2.55A resolution; E-site Deacylated tRNAgly 7u2h 2A 2800 2.55 RF02540,RF02541,RF00002 URS00001698E8_300852 35766409 0003735 0005840 300852 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<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<............>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<..>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...((((((((.....))))))))....{.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).))))....(((((((((.[.....)))))))))....}.(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....(())....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((....(((..........)).)....)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((.().)))))))).))..........]]].)....))))))))))...)))))))(((((((())))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(......[..(((((..(((......((((((((....))))))))...)))..........].)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.((.))......(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Gly-NH-tRNAgly, aminoacylated P-site fMet-NH-tRNAmet, and deacylated E-site tRNAgly at 2.55A resolution; 23S Ribosomal RNA 7u2h 2B 120 2.55 RF00001 URS000080DEE8_300852 35766409 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>. .((((((((((....((((((.(....(((((((...(.....)...))))..)))...).)))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Gly-NH-tRNAgly, aminoacylated P-site fMet-NH-tRNAmet, and deacylated E-site tRNAgly at 2.55A resolution; 5S Ribosomal RNA 7u2h 2a 1503 2.55 RF00177,RF01959,RF01960 URS000080DFED_300852 35766409 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggau .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<......>>....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...((((((......))))))....(.(....).)....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.(.((....)).)).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}... Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Gly-NH-tRNAgly, aminoacylated P-site fMet-NH-tRNAmet, and deacylated E-site tRNAgly at 2.55A resolution; 16S Ribosomal RNA 7u2h 2v 13 2.55 35766409 10665 aaaaaugggguaa ............. ............. Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Gly-NH-tRNAgly, aminoacylated P-site fMet-NH-tRNAmet, and deacylated E-site tRNAgly at 2.55A resolution; MG-mRNA 7u2h 2w 72 2.55 RF00005 URS00003845FE_562 35766409 0030533 0006412 562 gcgggcgnaguucaaggagaacgagagcuucccaagcucuauacgagggnucgauucccuucgcccgcuccn <<<<<<<..<<<<.....>>>>.<<<<<<.....>>>>>>....<<<<<.......>>>>>>>>>>>>.... (((((.(..((((...[.)))).(((((.......))))).....((((..]....)))).).))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Gly-NH-tRNAgly, aminoacylated P-site fMet-NH-tRNAmet, and deacylated E-site tRNAgly at 2.55A resolution; A-site Aminoacyl-tRNA Gly-NH-tRNAgly 7u2h 2x 77 2.55 RF00005 URS000041AF00_562 35766409 0030533 0006412 562 cgcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaaccn .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Gly-NH-tRNAgly, aminoacylated P-site fMet-NH-tRNAmet, and deacylated E-site tRNAgly at 2.55A resolution; P-site Aminoacyl-tRNA fMet-NH-tRNAmet 7u2h 2y 73 2.55 RF00005 URS00003845FE_562 35766409 0030533 0006412 562 gcgggcgnaguucaagguagaacgagagcuucccaagcucuauacgagggnucgauucccuucgcccgcucca <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>....<<<<<.......>>>>>>>>>>>>.... (((((((..((((......)))).(((((.......)))))....(((((.......)))))))))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Gly-NH-tRNAgly, aminoacylated P-site fMet-NH-tRNAmet, and deacylated E-site tRNAgly at 2.55A resolution; E-site Deacylated tRNAgly 7u2i 1A 2871 2.55 RF02540,RF02541,RF00002 URS00001698E8_300852 35766409 0003735 0005840 300852 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<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>....<<<<<.....<<....>>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<.....<<<........>>>......>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..<<.........>>...>>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<........<<<<<......>>>>>.....>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<...>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((..(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((.(...((.(......).))...)..)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((..((.........))...))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((.((((((((.(......[..(((((..(((........(((.((....)).))).....)))..........].)))))).)))))))).)))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..(((...)))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Gly-NH-tRNAgly, aminoacylated P-site fMet-NH-tRNAmet, deacylated E-site tRNAgly, and chloramphenicol at 2.55A resolution; 23S Ribosomal RNA 7u2i 1B 120 2.55 RF00001 URS000080DEE8_300852 35766409 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> (((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).))))))))))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Gly-NH-tRNAgly, aminoacylated P-site fMet-NH-tRNAmet, deacylated E-site tRNAgly, and chloramphenicol at 2.55A resolution; 5S Ribosomal RNA 7u2i 1a 1500 2.55 RF00177,RF01959,RF01960 URS000080DFED_300852 35766409 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>...<<<......>>>...>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((..)))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((..((((....))))..))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((...(((.(((....))).)))....(((....)))....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Gly-NH-tRNAgly, aminoacylated P-site fMet-NH-tRNAmet, deacylated E-site tRNAgly, and chloramphenicol at 2.55A resolution; 16S Ribosomal RNA 7u2i 1v 13 2.55 35766409 10665 aaaaaugggguaa ............. ............. Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Gly-NH-tRNAgly, aminoacylated P-site fMet-NH-tRNAmet, deacylated E-site tRNAgly, and chloramphenicol at 2.55A resolution; MG-mRNA 7u2i 1w 73 2.55 RF00005 URS00003845FE_562 35766409 0030533 0006412 562 gcgggcgnaguucaagguagaacgagagcuucccaagcucuauacgagggnucgauucccuucgcccgcuccn <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[..)))).(((((.......)))))....(((((..]....)))))))))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Gly-NH-tRNAgly, aminoacylated P-site fMet-NH-tRNAmet, deacylated E-site tRNAgly, and chloramphenicol at 2.55A resolution; A-site Aminoacyl-tRNA Gly-NH-tRNAgly 7u2i 1x 77 2.55 RF00005 URS000041AF00_562 35766409 0030533 0006412 562 cgcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaaccn .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Gly-NH-tRNAgly, aminoacylated P-site fMet-NH-tRNAmet, deacylated E-site tRNAgly, and chloramphenicol at 2.55A resolution; P-site Aminoacyl-tRNA fMet-NH-tRNAmet 7u2i 1y 73 2.55 RF00005 URS00003845FE_562 35766409 0030533 0006412 562 gcgggcgnaguucaagguagaacgagagcuucccaagcucuauacgagggnucgauucccuucgcccgcucca <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>....<<<<<.......>>>>>>>>>>>>.... (((((((..((((......)))).(((((.......))))).....((((.......)))).))))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Gly-NH-tRNAgly, aminoacylated P-site fMet-NH-tRNAmet, deacylated E-site tRNAgly, and chloramphenicol at 2.55A resolution; E-site Deacylated tRNAgly 7u2i 2A 2800 2.55 RF02540,RF02541,RF00002 URS00001698E8_300852 35766409 0003735 0005840 300852 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<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<....<<<..........>>.>....>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<..>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<..>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> .........((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....(())....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((.....((..........))......)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((.().)))))))).))..........]]].)....))))))))))...)))))))(((((((..)))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((.((((((((.(......[..(((((..((.......((((((((....))))))))....))..........].)))))).)))))))).)))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.(...)......(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)... Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Gly-NH-tRNAgly, aminoacylated P-site fMet-NH-tRNAmet, deacylated E-site tRNAgly, and chloramphenicol at 2.55A resolution; 23S Ribosomal RNA 7u2i 2B 120 2.55 RF00001 URS000080DEE8_300852 35766409 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>. .((((((((((....((((((.(....(((((((...(.....)...))))..)))...).)))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Gly-NH-tRNAgly, aminoacylated P-site fMet-NH-tRNAmet, deacylated E-site tRNAgly, and chloramphenicol at 2.55A resolution; 5S Ribosomal RNA 7u2i 2a 1503 2.55 RF00177,RF01959,RF01960 URS000080DFED_300852 35766409 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggau .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<.....>.>....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<..<.<<<<<<<........>>>>>>>>...>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((.(....).)))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...((((((......))))))....(.(....).)....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..(.((....)).)..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}... Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Gly-NH-tRNAgly, aminoacylated P-site fMet-NH-tRNAmet, deacylated E-site tRNAgly, and chloramphenicol at 2.55A resolution; 16S Ribosomal RNA 7u2i 2v 13 2.55 35766409 10665 aaaaaugggguaa ............. ............. Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Gly-NH-tRNAgly, aminoacylated P-site fMet-NH-tRNAmet, deacylated E-site tRNAgly, and chloramphenicol at 2.55A resolution; MG-mRNA 7u2i 2w 72 2.55 RF00005 URS00003845FE_562 35766409 0030533 0006412 562 gcgggcgnaguucaaggagaacgagagcuucccaagcucuauacgagggnucgauucccuucgcccgcuccn <<<<<<<..<<<<.....>>>>.<<<<<<.....>>>>>>....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[.)))).(((((.......))))).....((((..]....)))).))))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Gly-NH-tRNAgly, aminoacylated P-site fMet-NH-tRNAmet, deacylated E-site tRNAgly, and chloramphenicol at 2.55A resolution; A-site Aminoacyl-tRNA Gly-NH-tRNAgly 7u2i 2x 77 2.55 RF00005 URS000041AF00_562 35766409 0030533 0006412 562 cgcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaaccn .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Gly-NH-tRNAgly, aminoacylated P-site fMet-NH-tRNAmet, deacylated E-site tRNAgly, and chloramphenicol at 2.55A resolution; P-site Aminoacyl-tRNA fMet-NH-tRNAmet 7u2i 2y 73 2.55 RF00005 URS00003845FE_562 35766409 0030533 0006412 562 gcgggcgnaguucaagguagaacgagagcuucccaagcucuauacgagggnucgauucccuucgcccgcucca <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>....<<<<<.......>>>>>>>>>>>>.... (((((((..((((......)))).(((((.......))))).....((((.......)))).))))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Gly-NH-tRNAgly, aminoacylated P-site fMet-NH-tRNAmet, deacylated E-site tRNAgly, and chloramphenicol at 2.55A resolution; E-site Deacylated tRNAgly 7u2j 1A 2871 2.55 RF02540,RF02541,RF00002 URS00001698E8_300852 35766409 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<.....<<<........>>>......>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..<<<.....(.>>>...>>>.........<<......>>.).>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<.......<<<<<<......>>>>>>....>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((..(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((.(..(((.(......).)..)))..)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((..((.........))...))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((.(((((((((.(.........(((((..(((........(((.((....)).))).....)))............)))))).))))))))).))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..(((...)))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Gly-NH-tRNAgly, peptidyl P-site fMAC-NH-tRNAmet, deacylated E-site tRNAgly, and chloramphenicol at 2.55A resolution; 23S Ribosomal RNA 7u2j 1B 120 2.55 RF00001 URS000080DEE8_300852 35766409 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> (((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).))))))))))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Gly-NH-tRNAgly, peptidyl P-site fMAC-NH-tRNAmet, deacylated E-site tRNAgly, and chloramphenicol at 2.55A resolution; 5S Ribosomal RNA 7u2j 1a 1500 2.55 RF00177,RF01959,RF01960 URS000080DFED_300852 35766409 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<......>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((((((....))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((..((((....))))..))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((.(((....))).)))...((((....))))...)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Gly-NH-tRNAgly, peptidyl P-site fMAC-NH-tRNAmet, deacylated E-site tRNAgly, and chloramphenicol at 2.55A resolution; 16S Ribosomal RNA 7u2j 1v 13 2.55 35766409 10665 aaaaaugggguaa ............. ............. Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Gly-NH-tRNAgly, peptidyl P-site fMAC-NH-tRNAmet, deacylated E-site tRNAgly, and chloramphenicol at 2.55A resolution; MG-mRNA 7u2j 1w 73 2.55 RF00005 URS00003845FE_562 35766409 0030533 0006412 562 gcgggcgnaguucaagguagaacgagagcuucccaagcucuauacgagggnucgauucccuucgcccgcuccn <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[..)))).(((((.......))))).....((((..]....)))).))))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Gly-NH-tRNAgly, peptidyl P-site fMAC-NH-tRNAmet, deacylated E-site tRNAgly, and chloramphenicol at 2.55A resolution; A-site Aminoacyl-tRNA Gly-NH-tRNAgly 7u2j 1x 77 2.55 RF00005 URS000041AF00_562 35766409 0030533 0006412 562 cgcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaaccn .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Gly-NH-tRNAgly, peptidyl P-site fMAC-NH-tRNAmet, deacylated E-site tRNAgly, and chloramphenicol at 2.55A resolution; P-site Peptidyl-tRNA fMAC-NH-tRNAmet RNA-part 7u2j 1y 73 2.55 RF00005 URS00003845FE_562 35766409 0030533 0006412 562 gcgggcgnaguucaagguagaacgagagcuucccaagcucuauacgagggnucgauucccuucgcccgcucca <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>....<<<<<.......>>>>>>>>>>>>.... (((((((..((((......)))).(((((.......)))))....(((((.......)))))))))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Gly-NH-tRNAgly, peptidyl P-site fMAC-NH-tRNAmet, deacylated E-site tRNAgly, and chloramphenicol at 2.55A resolution; E-site Deacylated tRNAgly 7u2j 2A 2800 2.55 RF02540,RF02541,RF00002 URS00001698E8_300852 35766409 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<............>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<..>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....(())....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((....(((..........)).)....)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((.().)))))))).))..........]]].)....))))))))))...)))))))(((((((..)))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((.((((((((.(......[..(((((..((.......((((((((....))))))))....))..........].)))))).)))))))).)))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..((((((((........)))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))((((.))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Gly-NH-tRNAgly, peptidyl P-site fMAC-NH-tRNAmet, deacylated E-site tRNAgly, and chloramphenicol at 2.55A resolution; 23S Ribosomal RNA 7u2j 2B 120 2.55 RF00001 URS000080DEE8_300852 35766409 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Gly-NH-tRNAgly, peptidyl P-site fMAC-NH-tRNAmet, deacylated E-site tRNAgly, and chloramphenicol at 2.55A resolution; 5S Ribosomal RNA 7u2j 2a 1503 2.55 RF00177,RF01959,RF01960 URS000080DFED_300852 35766409 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggau .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<......>>....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<..<.<<<<<<<........>>>>>>>>...>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((.(....).)))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((((((....)))))))....(.(....).)....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.(.((....)).)).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}... Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Gly-NH-tRNAgly, peptidyl P-site fMAC-NH-tRNAmet, deacylated E-site tRNAgly, and chloramphenicol at 2.55A resolution; 16S Ribosomal RNA 7u2j 2v 13 2.55 35766409 10665 aaaaaugggguaa ............. ............. Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Gly-NH-tRNAgly, peptidyl P-site fMAC-NH-tRNAmet, deacylated E-site tRNAgly, and chloramphenicol at 2.55A resolution; MG-mRNA 7u2j 2w 72 2.55 RF00005 URS00003845FE_562 35766409 0030533 0006412 562 gcgggcgnaguucaaggagaacgagagcuucccaagcucuauacgagggnucgauucccuucgcccgcuccn <<<<<<<..<<<<.....>>>>.<<<<<<.....>>>>>>....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[.)))).(((((.......))))).....((((..]....)))).))))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Gly-NH-tRNAgly, peptidyl P-site fMAC-NH-tRNAmet, deacylated E-site tRNAgly, and chloramphenicol at 2.55A resolution; A-site Aminoacyl-tRNA Gly-NH-tRNAgly 7u2j 2x 77 2.55 RF00005 URS000041AF00_562 35766409 0030533 0006412 562 cgcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaaccn .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Gly-NH-tRNAgly, peptidyl P-site fMAC-NH-tRNAmet, deacylated E-site tRNAgly, and chloramphenicol at 2.55A resolution; P-site Peptidyl-tRNA fMAC-NH-tRNAmet RNA-part 7u2j 2y 73 2.55 RF00005 URS00003845FE_562 35766409 0030533 0006412 562 gcgggcgnaguucaagguagaacgagagcuucccaagcucuauacgagggnucgauucccuucgcccgcucca <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>....<<<<<.......>>>>>>>>>>>>.... (((((((..((((......)))).(((((.......)))))....(((((.......)))))))))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Gly-NH-tRNAgly, peptidyl P-site fMAC-NH-tRNAmet, deacylated E-site tRNAgly, and chloramphenicol at 2.55A resolution; E-site Deacylated tRNAgly 7u87 A 15 1.701 38579124 32630 nnnnacuuaagucnn ............... ............... Product of 13mer primer with activated G monomer diastereomer 1; RNA (5'-R(*(LCC)P*(LCC)P*(LCC)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*(G46)P*(G46))-3') 7u87 B 15 1.701 38579124 32630 nnnnacuuaagucnn ............... ............... Product of 13mer primer with activated G monomer diastereomer 1; RNA (5'-R(*(LCC)P*(LCC)P*(LCC)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*(G46)P*(G46))-3') 7u88 A 15 2.14 38579124 32630 nnnnacuuaagucnn ............... ............... Product of 13mer primer with activated G monomer diastereomer 2; RNA (5'-R(*(LKC)P*(LCC)P*(LCC)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*(G46)P*(G46))-3') 7u88 B 15 2.14 38579124 32630 nnnnacuuaagucnn ............... ............... Product of 13mer primer with activated G monomer diastereomer 2; RNA (5'-R(*(LKC)P*(LCC)P*(LCC)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*(G46)P*(G46))-3') 7u89 A 15 1.65 38579124 32630 nnnnacuuaagucgn ............... ............... Product of 14mer primer with activated G monomer diastereomer 1; RNA (5'-R(*(LKC)P*(LCC)P*(LCC)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*GP*(G46))-3') 7u89 B 15 1.65 38579124 32630 nnnnacuuaagucgn ............... ............... Product of 14mer primer with activated G monomer diastereomer 1; RNA (5'-R(*(LKC)P*(LCC)P*(LCC)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*GP*(G46))-3') 7u8a A 15 2.1 38579124 32630 nnnnacuuaagucgn ............... ............... Product of 14mer primer with activated G monomer diastereomer 2; RNA (5'-R(*(LKC)P*(LCC)P*(LCC)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*GP*(G46))-3') 7u8a B 15 2.1 38579124 32630 nnnnacuuaagucgn ............... ............... Product of 14mer primer with activated G monomer diastereomer 2; RNA (5'-R(*(LKC)P*(LCC)P*(LCC)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*GP*(G46))-3') 7u8b A 15 1.73 32630 nnnnacuuaagucgn ............... ............... Product of 14mer primer with activated asymmetric GA dimer diastereomer 1; RNA (5'-R(*(TLN)P*(LCC)P*(LCC)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*GP*(G46))-3') 7u8b B 15 1.73 32630 nnnnacuuaagucgn ............... ............... Product of 14mer primer with activated asymmetric GA dimer diastereomer 1; RNA (5'-R(*(TLN)P*(LCC)P*(LCC)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*GP*(G46))-3') 7ucj 2 72 3.1 RF00005 URS00023359AF_9986 35679869 0030533 0006412 9986 gagcagaguggcgcaggagcgugcugggcccaunacccagaggcgauggaucgaaaccauccucugcuacca <....<...<...........>.<<<<<.......>>>>>....<<<<<.......>>>>>.>....>.... .........(......[....).(((((.......)))))....(((((..]....)))))........... Mammalian 80S translation initiation complex with mRNA and Harringtonine; P-site tRNA 7ucj 5 3499 3.1 RF02540,RF02543 URS00023359B0_9986 35679869 0003735 0005840 9986 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggaaauguggcguacggaagacccacuccccggcgccggggggcccaaguccuucugaucgaggcccagcccguggacggugugagnccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaanggaaaguugaaaagaacuuugaagngagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggccgguccggccgugccggcggggcggaucucccgcucccgucggcgggggaccgccccccggccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcunggaaggccccggcggggaagguggcccgggggccccggguguuacagccccgccccggcagcagcagcucgccgaaucccggggccgagggagcgagacccgugccgccgcgcucuccccccugggggggccgggccaccccucccacggcgcgaccgcuggggcggacuguccagugcgccccgggcgggucgcgccgucgggcccgggggccacggcgucccccgcgagcgcacggggucggcggcgaugucggcuacccacccgacccnucuugnaacncggaccaaggagucuaacacgngcgcgagucgggggcuacgaaagccgccguggcgcaaugaaggugaaggccggcggcgccgccggccgaggugggaucccgaggccuuccaguccgccgagggngcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuagnacccnanagauggugancuaugccugggcagggcgaagccagaggaaacucuggugnagguccguagcgguccugacgugcgaaucgnucguccgaccuggguauagnggcgaaagacuaaucgaaccaucuaguagcuggnucccuccaaaguuucccucaggauagcuggcgcucuccgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaaungguaagaagcccggcucgcugguguggagccgggcguggaaugcgagugccuagugggccacnuuuggnaagcngaacuggcgcuncgggaugaaccgaacgccggguuaangcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggaccugccgaaucaacuagcccugaaaauggaugncgcuggagcgucgggcccauacccggccgucgcuggcagucggcagagcgagaaagagaguggcgcggacgcuacgccgcgacgaguaggagggccgcugcgnugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguagunnnaaauauucaaacganaacuuugaaggccgaaguggngaaggguuccaugugaacagnanuugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucagccgaucgaaagggagucgnguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccggggnagaggguguaaaucucgcnccgggccguaccnauauccgcagcaggucuncaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagcnggauccguaacuucgggauaaggauuggcucuaagggcuggcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugccnagugcucugaaugucanagugnagaaauucaaugaagcgcggguaaacggcgggaguaacnaugacucucuuaagguagcnaanugccucnucaucuaauuagugacgcgcaugaauggaugancgagauucccacugucccuaccuacuauccagcgaaaccacngncaagggaacgngcuuggnggaaucagcngngaaagaaganccuguugagcuugacucuagucuggcacggugaagagacaugaucguuuuuucacugacccggngaggcgggggggcgagccgggcucucgcuucuggcgccaancgcccggccggccgggcgcgacccgcuccggggacagugccaggugggnaguuugacngnggcgguacaccugucaaacgguancgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucungauuuucagnacgaauacagaccgugaaagcggggccunacgauccuucugaccuuuungguuuuaagcaggannugucagaaaaguuaccacagggauaacuggcuuguggcggccangcguucauagcgacgucgcuuuuugauccuungaugucggcucuuccuaucauugunaagcagaauunaccaagcguungauuguucacccacuaauagggaacgugngcuggnnuuagancgucgugagacagnuuaguuuuacccuncugaugnuguguuguugccaugguaauccugcncaguacgagaggaaccgcagguncanacauuugguguaunugcuuggcugaggagccaauggggcgaagcuacnaucugugggauuaugacunaacgccucuaagucagaaucccgcccaggcggaacgauagcgccggagccucgguuggccucggauagccggucccccgccgggguccgguncngagagcccuucgucccgggaaacggggcggccggaaagggggccgcccucucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcugcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..[[[..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>>..<<<<<<<<<....<<<<<<<<..<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>...>>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<......>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<....<<<<<<<.<<<<<.<<<<<<<.<<<<<<<<<......>>>>>>>>>>>>>>>>>>>>>>>>>...>>>..>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<.<<<<<<<<<<<<<<<...<<..<<<..<<<<<<<......<<<<<<<<.>>>>>>>>.......>>>>>>>..>>>.........>>>>>>..>>>>>>>>>>>.....<<.....{.>>......<<<<<<.<<<<<<..>>>>>>.<<<<<<..<<<.<<<<<<<<<<<<<<<<<<<<<<<.<<<<..>>>>.>>>>>>.>>>.>>>>>>>>>>>.>>>...>>>>>>>.>>...........>>>>>>......>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<.....>>>>.....>>>...<<....>>...<<<<<<<<<..>>>>>>>>>..<<<<<...<<<..<<<...(((.[[.>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<...<<<.<<<<<<<<<...<<<....<<<..<.<<<..<<<<.<.........>.>>>>>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<........}...........]].)))............>>>>>>>>>....>>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<<....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<<<<<...>>>>>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<..<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<<<<<<<<<<<<..{{{..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>.>.>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<.<<<<<<<<<<<.>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.....<<....<<<<<....>>>>.>...>>..>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>...>>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<<.<<<<<<<<<<......>>>>>>>>>>...<<<<<.....<<<<..<<.<<<<<>>.>>>>>..............<<<<<<<<<..>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>>.<<<....>>>.>>)))]......((((((..(((..>>>>>>.)))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]].....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<}}}.>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.<<<<<<<..<<<<....<<<........<<<<<..<<<<<.>>>>>.>>>>>.......>>>...<<<..<<<<....<<<<<<<<<........>>>>>>.>>>...>>>>..>>>..............>>>>..>>.>>>>>.<<<<<.<.............>....<<.<<<<<<<.<<.....<<<<.<..<<<<<.>>>>>..>>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..(((((((((((.....)))))).))))....))))....(((((((((....((((((((.(((((((((..({((((......)))))....[[(...).(((....}]])))...).)))))))..)))))))))...)))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....(((((((((.(..(((((((.(((((.(((((((.((((((((.(.()..)))))))))))))))))))))))))...)))).)))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((..(((((((......((((((((.)))))))).......)))))))..))).........))))))..))))))))))).....(......{..)......((((((.((((((())))))).((((((..(((.(((((((((((((((((((((((.((((..)))).)))))).))).))))))))))).)))...))))))).)).........[.)))))).....))).)))))...)))))...)))))))).<((((........))))((((((..(.(((((((((((((..(((..(((((.....))))..)..)))...((....))...(((((((((..)))))))))..(((((...(((..(((]..[[[.[[[)))..)))....))))).(((((((((.((((......))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((........)))).)))..).))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((.(((((((...(((.((((((((....(((....(((..(.(((..(((.(..(.....)..).)))))).)..)))..)).)....))))))...(((((((((.(......))))))))))....))))))))))))..))..((((..((((.....))))..))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.....A.(((((.)))))...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((........}.........].]].]]]............)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...(.....(((....)))..........((.(((((((((...))))))))))).......)....))...(((((........)))))]]((((....(((((...((.((((....)))).))..((((....)))...(...((((((...(((((((((((((((((((((((...{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((.)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(...(......(((......)))......).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.(((((((((.((((((((((......))))))))))...(((((.....((((..((..(((().))).))..............(((((.(((()))).)))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(..((..((((....{..))))..)).)(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......(....(.((((((...((.......))...))))))...)....)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))....))..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}..)))))..)).))...))))...)))).((((...((((.....a.......))))...))))..)))...).)))))).(((((.(..((((....(((.........((((...((((.))))..))))........)))...(((..(((.....(((.(((((........)))))..)))....)))..)))..............))))..)..))))).(((((.(..(.......)..)....((.(((((((.((.....((((.(..(((((.)))))..)))))....))....)))).))).))..))))).. Mammalian 80S translation initiation complex with mRNA and Harringtonine; 28s rRNA 7ucj 7 120 3.1 RF00001 URS000002B0D5_9986 35679869 0003735 0005840 9986 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. Mammalian 80S translation initiation complex with mRNA and Harringtonine; 5S rRNA 7ucj 8 150 3.1 RF00002 URS00023359AE_9986 35679869 0003735 0005840 9986 gacucuuagcggnggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcagguugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu ........................................<<<<<<<<<....>>>>.....<.<<<......>>........>>>..>...>>>....<<<..>>><<<<<<<<.......>>>>>>>>.................... ........................................((((((.[[.....))).....(.(((......]]........)))..)...)))....((....))((((((((.......)))))))).................... Mammalian 80S translation initiation complex with mRNA and Harringtonine; 5.8S rRNA 7ucj 9 1698 3.1 RF01960,RF01959,RF00177 URS0000E60B90_9986 35679869 0003735 0005840 9986 uaccugguugauccugccaguagcaunugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuauggunccuunggucgcucguacuuggauaacugugguanuucuagngcuaauanaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgcccggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcnaauuacccacucccgacccgggganguagugangaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugagucnacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauancguauauuaaaguugcugcaguunaaaagcucguaguungaucuugggagcggccguccccugcucggcgccggcccgaagcguuuacuuugaaaaaanuagaguguucaaagcaggccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagancgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccacnaggaguggagccugcggcuuaauuugacncaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggcnguucuuaguugguggagcgauuugucugguuaauucngauaacgaacgagacucuggcaugcuaacuaguuacgcgaccccggucggcguaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauunagucccugcccuuuguacacaccgnccgucgnuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggugcccuggcggagcgcugagaagacggucgaacuugncuaucuagaggaaguaaaagucgnancaagguuucnguaggugnnccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<....<<....<<<...........<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<<<....>>>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<<.>>>>>>>>....>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....<<<<<<<<<.<<<....>>>..>>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<....<<<.<<<..>>>.>>>.<<<<<<.<<..>>>>>>.>>..<<<<<<.<.......<<...<.......>.<<<<.>>>>...>>......>.>>>..>>>........<.<<.<<<<<<<...............>>>>>>>.>>.>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<<....>>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<..>>>>.>>>>>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>>....>.>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<.<<<<<<<<<..>>>>>>>>>...>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..((....(((.....(([...((.....((.(((.....))).))......))......))..(((...(((((......)))))...))).((..(((((...(......)..)))))......)).(]((((.((((.)))))))))...)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).).....(((((((((.(((....)))..)))))).)))....(.((..(...........)..))......)..((((([[......((((.....((..]])).......)))).)))))..)))))).)))..[......(.([[...(.(.((...(((..(....(((.(((())).)))).((((((.((())))))).))..((((((.(.......((..((.......)).(((.)))....))......).)))..)))........(.((.((((((.................)))))).)).)....)....(((..(...(...((((..(((.((((((((...((........))......)))))))).))).......((....))...))))..)...)...))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.(((((....))))))))))).)..)))...((..]]))...))...].))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((..((........))..))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((...(...((((..((((((((((((..)))).))))))))..))))..).....(((((.....)))))........)))....))).))).....).))))).....).)))))...)).)))).))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..((((.((...(((((((((((.(((..))).))))).).)))))...)).))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}........ Mammalian 80S translation initiation complex with mRNA and Harringtonine; 18S rRNA 7uck 2 72 2.8 RF00005 URS00023359AF_9986 35679869 0030533 0006412 9986 gagcagaguggcgcaggagcgugcugggcccaunacccagaggcgauggaucgaaaccauccucugcuacca <....<...<...........>.<<<<<.......>>>>>....<<<<<.......>>>>>.>....>.... .........(......[....).(((((.......)))))....(((((..]....)))))........... 80S translation initiation complex with ac4c(-1) mRNA and Harringtonine; P-site tRNA 7uck 5 3546 2.8 RF02540,RF02543 URS00023359AC_9986 35679869 0003735 0005840 9986 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggaaauguggcguacggaagacccacuccccggcgccggggggcccaaguccuucugaucgaggcccagcccguggacggugugagnccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaanggaaaguugaaaagaacuuugaagngagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggccgguccggccgugccggcggggcggaucucccgcucccgucggcgggggaccgccccccggccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcunggaaggccccggcggggaagguggcccgggggccccggguguuacagccccgccccggcagcagcagcucgccgaaucccggggccgagggagcgagacccgugccgccgcgcucuccccccugggggggccgggccaccccucccacggcgcgaccgcuggggcggacuguccagugcgccccgggcgggucgcgccgucgggcccgggggccacggcgucccccgcgagcgcacggggucggcggcgaugucggcuacccacccgacccnucuugnaacncggaccaaggagucuaacacgngcgcgagucgggggcuacgaaagccgccguggcgcaaugaaggugaaggccggcggcgccgccggccgaggugggaucccgaggccuuccaguccgccgagggngcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuagnacccnanagauggugancuaugccugggcagggcgaagccagaggaaacucuggugnagguccguagcgguccugacgugcgaaucgnucguccgaccuggguauagnggcgaaagacuaaucgaaccaucuaguagcuggnucccuccaaaguuucccucaggauagcuggcgcucuccgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaaungguaagaagcccggcucgcugguguggagccgggcguggaaugcgagugccuagugggccacnuuuggnaagcngaacuggcgcuncgggaugaaccgaacgccggguuaangcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggaugguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggaugncgcuggagcgucgggcccauacccggccgucgcuggcagucggcagagcgagaaagagaguggcgcggacgcuacgccgcgacgaguaggagggccgcugcgnugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguagunnnaaauauucaaacganaacuuugaaggccgaaguggngaaggguuccaugugaacagnanuugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucagccgaucgaaagggagucgnguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccggggnagaggguguaaaucucgcnccgggccguaccnauauccgcagcaggucuncaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagcnggauccguaacuucgggauaaggauuggcucuaagggcuggcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugccnagugcucugaaugucanagugnagaaauucaaugaagcgcggguaaacggcgggaguaacnaugacucucuuaagguagcnaanugccucnucaucuaauuagugacgcgcaugaauggaugancgagauucccacugucccuaccuacuauccagcgaaaccacngncaagggaacgngcuuggnggaaucagcngngaaagaaganccuguugagcuugacucuagucuggcacggugaagagacaugaucguuuuuucacugacccggngaggcgggggggcgagccgggcucucgcuucuggcgccaancgcccggccggccgggcgcgacccgcuccggggacagugccaggugggnaguuugacngnggcgguacaccugucaaacgguancgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucungauuuucagnacgaauacagaccgugaaagcggggccunacgauccuucugaccuuuungguuuuaagcaggannugucagaaaaguuaccacagggauaacuggcuuguggcggccangcguucauagcgacgucgcuuuuugauccuungaugucggcucuuccuaucauugunaagcagaauunaccaagcguungauuguucacccacuaauagggaacgugngcuggnnuuagancgucgugagacagnuuaguuuuacccuncugaugnuguguuguugccaugguaauccugcncaguacgagaggaaccgcagguncanacauuugguguaunugcuuggcugaggagccaauggggcgaagcuacnaucugugggauuaugacunaacgccucuaagucagaaucccgcccaggcggaacgauagcgccggagccucgguuggccucggauagccggucccccgccgggguccgguncngagagcccuucgucccgggaaacggggcggccggaaagggggccgcccucucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcugcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..[[[..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>>..<<<<<<<<<....<<<<<<<<..<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>...>>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<....<<<<<<<.<<<<<.<<<<<<<.<<<<<<<<<......>>>>>>>>>>>>>>>>>>>>>>>>>...>>>..>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<<<<<<<<<<<<<<<<<...<<..<<<..<<<<<<<......<<<<<<<<.>>>>>>>>.......>>>>>>>..>>>.........>>>>>>..>>>>>>>>>>>.....<<.....{.>>......<<<<<<.<<<<<<..>>>>>>.<<<<<<..<<<.<<<<<<<<<<<<<<<<<<<<<<<.<<<<..>>>>.>>>>>>.>>>.>>>>>>>>>>>.>>>...>>>>>>>.>>...........>>>>>>.....>>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<.....>>>>.....>>>...<<....>>...<<<<<<<<....>>>>>>>>..<<<<<...<<<..<<<...(((.[[.>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<...<<<.<<<<<<<<<...<<<....<<<..<.<<<..<<<<.<.........>.>>>>>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<.....................>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<........}...........]].)))............>>>>>>>>>....>>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<<<<<...>>>>>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<..<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<<<<<<<<<<<<..{{{..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>.>.>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<.>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.....<<.....<<<<....>>>>.....>>..>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<<.<<<<<<<<<<......>>>>>>>>>>...<<<<<.....<<<<..<<.<.<<<>>.>>.>>..............<<<<<<<<<..>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>>.<<<....>>>.>>)))]......((((((..(((..>>>>>>.)))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]].....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<}}}.>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.<<<<<<<..<<<<....<<<........<<<<<..<<<<<.>>>>>.>>>>>.......>>>...<<<..<<<<....<<<<<<<<<........>>>>>>.>>>...>>>>..>>>..............>>>>..>>.>>>>>.<<<<<.<.............>....<<.<<<<<<<.<<.....<<<<.<..<<<<<.>>>>>..>>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..(((((((((((.....)))))).))))....))))....(((((((((....((((((((.(((((((((..({((((......)))))....[[(...).(((....}]])))...).)))))))..)))))))))...)))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....(((((((((.(..(((((((.(((((.(((((((.((((((((.(.()..)))))))))))))))))))))))))...)))).)))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((..(((((((......((((((((.)))))))).......)))))))..))).........))))))..))))))))))).....(......{..)......((((((.((((((..)))))).((((((..(((.((((((((((((((((.((((((.((((..)))).))))))..)).))))))))))).)))...))))))).)).........[.)))))).....))).)))))...)))))...)))))))).<((((........))))((((((....(((((((((((((..(((..(((((.....))))..)..)))...((....))...(((((((((..)))))))))..(((((...(((..(((]..[[[.[[[)))..)))....))))).(((((((((.((((......))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((........)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((...(((.((((((((....(((....(((..(.(((..(((.(..(.....)..).)))))).)..)))..)).)....))))))...(((((((((.(......))))))))))....))))))))))))..))..((((..((((.....))))..))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.....A.(((((..((...................))......(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((........}.........].]].]]]............)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...(.....(((....)))..........((.((((.((((...)))).)))))).......)....))...(((((........)))))]]((((....(((((...((.((((....)))).))..((((....)))...(...((((((...(((((((((((((((((((((((...{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((.)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(...(......(((......)))......).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.(((((((((.((((((((((......))))))))))...(((((.....((((..((.(.((().))).))..............(((((((((())))))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(..((..((((....{..))))..)).)(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......(....(.((((((...((.......))...))))))...)....)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))....))..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}..)))))..)).))...))))...)))).((((...((((.....a.......))))...))))..)))...).)))))).(((((.(..((((....(((.........((((...((((.))))..))))........)))...(((..(((.....(((.(((((........)))))..)))....)))..)))..............))))..)..))))).(((((.(..(.......)..)....((.(((((((.((.....((((.(..(((((.)))))..)))))....))....)))).))).))..))))).. 80S translation initiation complex with ac4c(-1) mRNA and Harringtonine; 28s rRNA 7uck 7 120 2.8 RF00001 URS000002B0D5_9986 35679869 0003735 0005840 9986 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. 80S translation initiation complex with ac4c(-1) mRNA and Harringtonine; 5S rRNA 7uck 8 151 2.8 RF00002 URS00023359AE_9986 35679869 0003735 0005840 9986 cgacucuuagcggnggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcagguugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<<<<....>>>>.....<.<<<......>>........>>>..>...>>>....<<<..>>><<<<<<<<.......>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]]........)))..)...)))....((....))((((((((.......)))))))).................... 80S translation initiation complex with ac4c(-1) mRNA and Harringtonine; 5.8S rRNA 7uck 9 1698 2.8 RF01960,RF01959,RF00177 URS0000E60B90_9986 35679869 0003735 0005840 9986 uaccugguugauccugccaguagcaunugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuauggunccuunggucgcucguacuuggauaacugugguanuucuagngcuaauanaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgcccggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcnaauuacccacucccgacccgggganguagugangaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugagucnacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauancguauauuaaaguugcugcaguunaaaagcucguaguungaucuugggagcggccguccccugcucggcgccggcccgaagcguuuacuuugaaaaaanuagaguguucaaagcaggccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagancgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccacnaggaguggagccugcggcuuaauuugacncaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggcnguucuuaguugguggagcgauuugucugguuaauucngauaacgaacgagacucuggcaugcuaacuaguuacgcgaccccggucggcguaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauunagucccugcccuuuguacacaccgnccgucgnuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggugcccuggcggagcgcugagaagacggucgaacuugncuaucuagaggaaguaaaagucgnancaagguuucnguaggugnnccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<..<.....<<<.<....<<....<<<...........<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<<<....>>>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<<.>>>>>>>>....>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>>>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....<<<<<<<<<.<<<....>>>..>>>>>>.>>>......<<..<...........>..>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<....<<<.<<<..>>>.>>><<<<<<<.<<..>>>>>>.>>>.<<<<<<.<.......<<...<.......>.<<<<.>>>>...>>......>.>>>..>>>........<.<<.<<<<<<<...............>>>>>>>.>>.>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<<....>>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<..>>>>.>>>>>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<.<<<<<<<<<..>>>>>>>>>...>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..((....(((.....(([...((.....((.(((.....))).))......))......))..(((...((((((....))))))...))).((..(((((...(......)..)))))......)).(]((((.((((.)))))))))...)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).).....(((((((((.(((....)))..)))))).)))....(.((..(...........)..))......)..((((([[......((((.....((..]])).......)))).)))))..)))))).)))..[......(.([[...(.(.((...(((..(....(((..((()))..))).((((((.((())))))).))..((((((.(.......((..((.......)).(((.)))....))......).)))..)))........(.((.((((((.................)))))).)).)....)....(((..(...(...((((..(((.((((((((...((........))......)))))))).))).......((....))...))))..)...)...))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.(((((....))))))))))).)..)))...((..]]))...))...].))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((..((........))..))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((...(...((((..((((((((((((..)))).))))))))..))))..).....(((((.....)))))........)))....))).))).....).))))).....).)))))...)).)))).))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..((((.((...(((((((((((((((..))))))))).).)))))...)).))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}........ 80S translation initiation complex with ac4c(-1) mRNA and Harringtonine; 18S rRNA 7ug6 1 3058 2.9 RF02543 URS000061F377_559292 36536102 0003735 0005840 559292 guuugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaaacuuuaaauauguaagaaguccuuguuugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuugggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggagugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ..........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<<.<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>>..>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<......<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<...<<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>>.>>.>>....>>>>>>.>>>>>>>.<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>>.....>.>>..<<<<<<....<.<<<....>>>.><<<<<........<<<.<<<<<<<...<...............>...>>>>>...<<<<............>>>>.....>>>>>......>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>>..<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>...<...<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..[[[..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>...>......>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<...............>>>>><<.<<<<<<<<<<<..>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>.......<<...<<<<<..<..........<<<<....>>>>........>.>>>..>>.>><<<.<<.......>.>.>>>.........<<..>>......>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<....>>>>>....(((((..[[[........(((((.{{((((..<<<<<.<<<<<<<<..<<<<<<<<<.....>>>>>>>>>...<<<<<.....<<<<...<<<<......>>>>................<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>......<.<...<<<<<<<...........>>>>>>>......<<<<<<<...<<<<<<.......>>>>>>...................>>>>>>>...<<<..<<<<.......>>>>..>>>.<<<....>>>...>.>.{.....{.[[[...((((.>>>>>>)))).]]].}......}...))))..}}))))).............<<<<<<...<<.......>>...>>>>>>.................<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.<.....>.>>>.....>>>>>>...>>>>......<<<<<<<....>>>.>>>>........]]].)))))....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<....<<<<<<<<<<]]].>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<.....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>..............>.>>>.>>>>>>..<<<<<<<.............>.....<<<<<<<<<.<<<....<<<<.<..<<<<<......>>>>>..>>>>>...>>>....>>>>.>>>>>.>>>>>>.. ..........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((.((((.(((((((((((.((((((((...({((((......)))))[[(...).(((....}]])))....))))))))...)))))))....)))))))).))...)....(.(((((........))))).).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.(((((......(((((((((((((((((((((((.......(((((((......(((((((..))))))).......))))))).....))))).))))))))))........(((....)))....)))))))).....))))).)))))..((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)(((((........(((.(((((((.........(....)........)))))...((((...((..))...)))).....)))))......))).))..((((.((.((.....)).)).))))....(((......)))...(((((((...((([[[...(.(((((.......(...........((.((((((((((.....{.(((((.(.(...((.........))...).).....(...((......)).).)))))...))))))))))))...........]]].).....)))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........((((((........))))))....))....))...(((((........)))))]]((((..(((((((...((((....)))...(.[.((((((...((((.((((((((((((((((((..{{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((..)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).]..........(..(((.(..........((((....))))........))))....)....(................)...........(..).......)).))))))).)..))).)))))))..))))))....)).[..(((((..].)))))....(((((..(((.(.......((((.((((((..(((((.(.(.((((..(((((((((.....)))))))))....((((.....((((...((((......))))............]...((((((....))))))..))))..))))......)))).).)..)))))......(.(.....(((((...........)))))........(((((((...((((((.......))))))......(.....)......)))))))...(((....(.........)....)))((((....))).).).).......(..((...((((.]]]]]])))).))..)..........))))..))))))..............((((((...((.......))...)))))).................((((.((((((..(.(((((((......))))))..).).(((.........))).....))))))...))))......(((.(((....)))..)))..a..)..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}}.)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......(.((((.(((.(.....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).))))))..............).))).)))).)..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Cryo-EM structure of pre-60S ribosomal subunit, unmethylated G2922; 25S rRNA 7ug6 2 158 2.9 RF00002 URS00001BF64E_559292 36536102 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<<<<....>>>>.....<.<<<......>>..............>>>..>...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Cryo-EM structure of pre-60S ribosomal subunit, unmethylated G2922; 5.8S rRNA 7ug7 16 1514 2.58 RF00177,RF01959,RF01960 URS000081169C_562 35500116 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacagguuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugccggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauc ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<.....>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<..>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<.<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>...<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>....>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((.....)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(..(.((((((((.......)))))))).)...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((((())))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(.....(((((..(((((((....)))))))....(....)...)))))...).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... 70S ribosome complex in an intermediate state of translocation bound to EF-G(GDP) stalled by Argyrin B; 16S rRNA 7ug7 23 2903 2.58 RF02540,RF02541 URS00004B0F34_562 35500116 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<<..>>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<<.....>>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<......<.<<<<<.<<<..<<<<.......>>>>..>>>........<<<......>>>..>>>>>.>..>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<<..>>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<<.<<....>>..>>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<<<<...<<.......<<<<<<<<....>>>>>>>>....>>.............>>>>...>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((.((((.....))))..))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.......(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((...((.(.(.....[...(((((..(.........((..(((....)))..))......)...]........)))))).).))...)))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). 70S ribosome complex in an intermediate state of translocation bound to EF-G(GDP) stalled by Argyrin B; 23S rRNA 7ug7 5 120 2.58 RF00001 URS0000049E57_562 35500116 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). 70S ribosome complex in an intermediate state of translocation bound to EF-G(GDP) stalled by Argyrin B; 5S rRNA 7ug7 Dt 77 2.58 RF00005 URS000057545F_562 35500116 0030533 0006412 562 cgcggggnggagcagcccggnagcucgucgggnucauaacccgaagnucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... 70S ribosome complex in an intermediate state of translocation bound to EF-G(GDP) stalled by Argyrin B; tRNA-fMet 7ug7 Pt 76 2.58 RF00005 URS00005AA258_562 35500116 0030533 0006412 562 gcccgganagcucagncgguagagcaggggauugaanauccccgunnccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>><<<<<<<.....>>>>>>.>...<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((.........)))).....(((((..]....)))))))))))).... 70S ribosome complex in an intermediate state of translocation bound to EF-G(GDP) stalled by Argyrin B; tRNA-Phe 7ug7 mR 10 2.58 35500116 562 gauguucaaa .......... .......... 70S ribosome complex in an intermediate state of translocation bound to EF-G(GDP) stalled by Argyrin B; mRNA 7unr a 1522 2.9 RF00177,RF01959,RF01960 URS00004149DE_208964 0003735 0005840 208964 gaacugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgagcggaugaagggagcuugcuccuggauucagcggcggacgggugaguaaugccuaggaaucugccugguagugggggauaacguccggaaacgggcgcuaauaccgcauacguccugagggagaaagugggggaucuucggaccucacgcuaucagaugagccuaggucggauuagcuaguuggugggguaaaggccuaccaaggcgacgauccguaacuggucugagaggaugaucagucacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauuggacaaugggcgaaagccugauccagccaugccgcgugugugaagaaggucuucggauuguaaagcacuuuaaguugggaggaagggcaguaaguuaauaccuugcuguuuugacguuaccaacagaauaagcaccggcuaacuucgugccagcagccncgguaauacgaagggugcaagcguuaaucggaauuacugggcguaaagcgcgcguaggugguucagcaaguuggaugugaaauccccgggcucaaccugggaacugcauccaaaacuacugagcuagaguacgguagagggugguggaauuuccuguguagcggugaaaugcguagauauaggaaggaacaccaguggcgaaggcgaccaccuggacugauacugacacugaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuagccguugggaucgaucuuaguggcgcagcuaacgcgauaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccuggccuugacaugcugagaacuuuccagagauggauuggugccuucgggaacucagacacaggugcugcauggcugucgucagcucgugucgugagauguuggguuaagucccguaacgagcgcaacccuuguccuuaguuaccagcaccucgggugggcacucuaaggagacugccggugacaaaccggaggaagguggggaugacgucaagucaucaugncccuuacggccagggcuacacacgugcuacaauggucgguacaaaggguugccaagccgcgagguggagcuaaucccauaaaaccgaucguaguccggaucgcagucugcaacucgacugcgugaagucggaaucgcuaguaaucgugaaucagaaugucacggugaauacguucccgggccuuguacacaccgnccgucacaccaugggaguggguugcuccagaaguagcuagucuaaccgcaagggggacgguuaccacggagugauucaugacuggggugaagucgnaacaagguagccguaggngnnccugcggcuggauc ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<....<<<<<<..>>>>>>....>>.>>>>>......<<.......<<<<<<<..<<...<<<<<<<<<.<<.....<<<<<<....>>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>>>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>...<.<<<<<......<<<<<<<<<<.......>>>>>>>>>>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<..<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>.>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<<..<<<......>>>.....>>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<..>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<......<<<....>>>.......<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((..((..(((..((.((.....(((((..))))).....)).)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....((......))....(((.((..((....)))).))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)).))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(..((.(((.(((.......))).))).))...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.((((((..((((((((((......((((((.....))))))....))))))))..)).))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((((())))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(...(((....)))...)...((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..((.......))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...((((((......(((..((...(((....)))...))....)))......))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....(((((..((((..((....)).)))).)))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Pseudomonas aeruginosa 70S ribosome initiation complex bound to compact IF2-GDP (composite structure I-A); 16S Ribosomal RNA 7unr v 76 2.9 RF00005 URS000041AF00_562 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Pseudomonas aeruginosa 70S ribosome initiation complex bound to compact IF2-GDP (composite structure I-A); P-site initiator tRNA 7unr A 2884 2.9 RF02540,RF02541 URS00003C2204_208964 0003735 0005840 208964 ggucaagugaagaagcgcauacgguggaugccuuggcagucagaggcgaugaaagacgugguagccugcgaaaagcuucggggagucggcaaacagacuuugauccggagaucucugaaugggggaacccaccuaggauaaccuagguaucuuguacugaauccauaggugcaagaggcgaaccaggggaacugaaacaucuaaguacccugaggaaaagaaaucaaccgagauucccuuaguaguggcgagcgaacggggauuagcccuuaagcuucauugauuuuagcggaacgcucuggaaagugcggccauagugggugauagccccguacgcgaaaggaucuuugaagugaaaucgaguaggacggagcacgagaaacuuugucugaacauggggggaccauccuccaaggcuaaauacuacugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggagaggggagugaaauagaaccugaaaccguaugcguacaagcagugggagccuacuuguuaggugacugcguaccuuuuguauaaugggucagcgacuuauauucaguggcaagcuuaaccguauaggguaggcguagcgaaagcgagucuuaauagggcguuuagucgcuggguauagacccgaaaccgggcgaucuauccaugagcagguugaagguuagguaacacugacuggaggaccgaacccacucccnuugaaaagguaggggaugacuuguggaucggagugaaaggcuaaucaagcucggagauagcugguucuccucgaaagcuauuuagguagcgccucauguaucacucugggggguagagcacuguuucggcuagggggucaucccgacuuaccaaaccgaugcaaacuccgaauacccagaagugccgagcaugggagacacacggcgggugcuaacguccgucgugaaaagggaaacaacccagaccgccagcuaaggucccaaaguugugguuaagugguaaacgaugugggaaggcuuagacagcuaggagguuggcuuagaagcagccacccuuuaaagaaagcguaauagcucacuagucgagucggccugcgcggaagauguaacggggcucaaaccacacaccgaagcugcgggugucacggugacgcgguagaggagcguucuguaagccugugaaggugaguugagaagcuugcuggagguaucagaagugcgaaugcugacaugaguaacgacaaugggugugaaaaacacccacgccgaaagaccaaggguuccugcgcaacguuaaucgacgcaggguuagucgguuccuaaggcgaggcugaaaagcguagucgaugggaaacagguuaauauuccuguacuucugguuacugcgauggagggacggagaaggcuaggccagcuuggcguugguuguccaaguuuaaggugguaggcugaaaucuuagguaaauccgggguuucaaggccgagagcugaugacgagucgucuagaugacgaagugguugaugccaugcuuccaagaaaagcuucuaagcuucagguaaccaggaaccguaccccaaaccgacacngguggucggguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggcaccguaacuucgggagaaggugcgccggcuagggugaaggauuuacuccguaagcucuggcuggucgaagauaccaggccgcugcgacuguuuauuaaaaacacagcacucugcaaacacgaaaguggacguauagggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaacgauggcggcgcugucuccacccgagacucagugaaauugaaaucgcugugnagaugcaguguauccgcggcuagacggaaagaccccgunaaccuuuacuguagcuuugcacuggacuuugagccugcuuguguaggauaggugggaggcuuugaagcguggacgccaguucgcguggagccauccuugaaauaccacccuggcaugcuugagguucuaacucugguccguaauccggaucgaggacaguguauggugggcaguuugacugnggcggucuccuccuaaagaguaacggaggaguacgaaggugcgcucagaccggucggaaaucggucgcagaguauaaaggcaaaagcgcgcuugacugcgagacagacacgucgagcagguacgaaaguaggucuuagugauccggugguucuguauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaagccggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccguggacguuugagauuugagaggggcugcuccuaguacgagaggaccggaguggacgaaccucugguguuccgguugucacgccaguggcauugccggguagcuauguucggaaaagauaaccgcugaaagcaucuaagcgggaaacuugccucaagaugagaucucacugggaacuugauuccccugaagggccgucgaagacuacgacguugauaggcuggguguguaagcguugugaggcguugagcuaaccaguacuaauugcccgugaggcuugacca <<<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))...].>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...(((.....<<<<<<..<<<<<..<<<...<<<.<......>.>>>((......<<<.....))>>>...>>>....>>>>>..>>>>>>...........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<<.....>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<.<<........>>.>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<..<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<.......>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>....>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<<..<<<<.......>>>>..>>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........)))......>>>>>>.>>>...>>>>>>><<<<<<<.>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<...((((...>>>>>><<..<<<....<<<<<<<<<<<..<<.....>>.>>>>>>>..>>>>....>>>...>><..<<<<<<..>>>>>>...>>>>>>...>>>...>>>.>........>>>>...>>....>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<...<<<.....>>>....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.......<<<<<<.<<....>>..>>>>>>.......>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<.<............<<<<...<............<<<<....>>>>.........>.............>>>>...>.>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))))>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<<<<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>...>>>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[[.[[[.))).....((((((...(((]]]..]].)))......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((....((((((..((((((.(((...(((.(......).)))[[(...).(((.....]])))...)))...))))))..))))))......)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((..).)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.((.((.......<)).)))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..(((((((((.....(((...(((.((((...((....(.....).....))...)))).)))..)).).....)))))).)))....))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{..((.(.(((..(((.........)))..))).....(..(((......)))).).))....)))..))))).))...........]]].)....))))))))))...)))))))(((((((.)))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((..((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..(((....((((((((((((.((.....))))))))))..))))..[.)))...))(..((((((..))))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((...((((..)])))....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((.((...((..(.........((((....(........(..((((....))))..).....)..............)))))..))...)).)))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))..).))))))))). Pseudomonas aeruginosa 70S ribosome initiation complex bound to compact IF2-GDP (composite structure I-A); 23S Ribosomal RNA 7unr B 117 2.9 RF00001 URS00005ACE34_208964 0003735 0005840 208964 gcuugacgaucauagagcguuggaaccaccugaucccuucccgaacucagaagugaaacgacgcaucgccgaugguaguguggggucuccccaugugagaguaggucaucgucaagc <<<<<<<<<<....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>><<<.......<<<<<<<<...>>>>>>>>.......>>>.>>>>>>>>>> (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((...)))))))).......)))..))))))))) Pseudomonas aeruginosa 70S ribosome initiation complex bound to compact IF2-GDP (composite structure I-A); 5S Ribosomal RNA 7unu a 1522 2.9 RF00177,RF01959,RF01960 URS00004149DE_208964 0003735 0005840 208964 gaacugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgagcggaugaagggagcuugcuccuggauucagcggcggacgggugaguaaugccuaggaaucugccugguagugggggauaacguccggaaacgggcgcuaauaccgcauacguccugagggagaaagugggggaucuucggaccucacgcuaucagaugagccuaggucggauuagcuaguuggugggguaaaggccuaccaaggcgacgauccguaacuggucugagaggaugaucagucacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauuggacaaugggcgaaagccugauccagccaugccgcgugugugaagaaggucuucggauuguaaagcacuuuaaguugggaggaagggcaguaaguuaauaccuugcuguuuugacguuaccaacagaauaagcaccggcuaacuucgugccagcagccncgguaauacgaagggugcaagcguuaaucggaauuacugggcguaaagcgcgcguaggugguucagcaaguuggaugugaaauccccgggcucaaccugggaacugcauccaaaacuacugagcuagaguacgguagagggugguggaauuuccuguguagcggugaaaugcguagauauaggaaggaacaccaguggcgaaggcgaccaccuggacugauacugacacugaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuagccguugggaucgaucuuaguggcgcagcuaacgcgauaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccuggccuugacaugcugagaacuuuccagagauggauuggugccuucgggaacucagacacaggugcugcauggcugucgucagcucgugucgugagauguuggguuaagucccguaacgagcgcaacccuuguccuuaguuaccagcaccucgggugggcacucuaaggagacugccggugacaaaccggaggaagguggggaugacgucaagucaucaugncccuuacggccagggcuacacacgugcuacaauggucgguacaaaggguugccaagccgcgagguggagcuaaucccauaaaaccgaucguaguccggaucgcagucugcaacucgacugcgugaagucggaaucgcuaguaaucgugaaucagaaugucacggugaauacguucccgggccuuguacacaccgnccgucacaccaugggaguggguugcuccagaaguagcuagucuaaccgcaagggggacgguuaccacggagugauucaugacuggggugaagucgnaacaagguagccguaggngnnccugcggcuggauc ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<....<<<<<<..>>>>>>....>>.>>>>>......<<.......<<<<<<<..<<...<<<<<<<<<.<<.....<<<<<<....>>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>>>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<<<<<<<<<<.<...>.>>>>>>>>>>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<..<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>.>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<<..<<<......>>>.....>>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<..>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<...<<<....>>>...>...<<<..>>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((....((((((..))))))....)).)))))......(((......(((((((..((...(((((((((.((.....((((((....))))))......)).).....(((....)))....((((((..((....))))))))))))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(..((((((.(((.......))).))))))...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.((((((..((((((((((......((((((.....))))))....))))))))..)).))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((((())))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(...(((....)))...)...((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...((((((......(((..((...(((....)))...))....)))......))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Pseudomonas aeruginosa 70S ribosome initiation complex bound to compact IF2-GDP (composite structure I-B); 16S Ribosomal RNA 7unu v 76 2.9 RF00005 URS000041AF00_562 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Pseudomonas aeruginosa 70S ribosome initiation complex bound to compact IF2-GDP (composite structure I-B); P-site initiator tRNA 7unu A 2884 2.9 RF02540,RF02541 URS00003C2204_208964 0003735 0005840 208964 ggucaagugaagaagcgcauacgguggaugccuuggcagucagaggcgaugaaagacgugguagccugcgaaaagcuucggggagucggcaaacagacuuugauccggagaucucugaaugggggaacccaccuaggauaaccuagguaucuuguacugaauccauaggugcaagaggcgaaccaggggaacugaaacaucuaaguacccugaggaaaagaaaucaaccgagauucccuuaguaguggcgagcgaacggggauuagcccuuaagcuucauugauuuuagcggaacgcucuggaaagugcggccauagugggugauagccccguacgcgaaaggaucuuugaagugaaaucgaguaggacggagcacgagaaacuuugucugaacauggggggaccauccuccaaggcuaaauacuacugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggagaggggagugaaauagaaccugaaaccguaugcguacaagcagugggagccuacuuguuaggugacugcguaccuuuuguauaaugggucagcgacuuauauucaguggcaagcuuaaccguauaggguaggcguagcgaaagcgagucuuaauagggcguuuagucgcuggguauagacccgaaaccgggcgaucuauccaugagcagguugaagguuagguaacacugacuggaggaccgaacccacucccnuugaaaagguaggggaugacuuguggaucggagugaaaggcuaaucaagcucggagauagcugguucuccucgaaagcuauuuagguagcgccucauguaucacucugggggguagagcacuguuucggcuagggggucaucccgacuuaccaaaccgaugcaaacuccgaauacccagaagugccgagcaugggagacacacggcgggugcuaacguccgucgugaaaagggaaacaacccagaccgccagcuaaggucccaaaguugugguuaagugguaaacgaugugggaaggcuuagacagcuaggagguuggcuuagaagcagccacccuuuaaagaaagcguaauagcucacuagucgagucggccugcgcggaagauguaacggggcucaaaccacacaccgaagcugcgggugucacggugacgcgguagaggagcguucuguaagccugugaaggugaguugagaagcuugcuggagguaucagaagugcgaaugcugacaugaguaacgacaaugggugugaaaaacacccacgccgaaagaccaaggguuccugcgcaacguuaaucgacgcaggguuagucgguuccuaaggcgaggcugaaaagcguagucgaugggaaacagguuaauauuccuguacuucugguuacugcgauggagggacggagaaggcuaggccagcuuggcguugguuguccaaguuuaaggugguaggcugaaaucuuagguaaauccgggguuucaaggccgagagcugaugacgagucgucuagaugacgaagugguugaugccaugcuuccaagaaaagcuucuaagcuucagguaaccaggaaccguaccccaaaccgacacngguggucggguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggcaccguaacuucgggagaaggugcgccggcuagggugaaggauuuacuccguaagcucuggcuggucgaagauaccaggccgcugcgacuguuuauuaaaaacacagcacucugcaaacacgaaaguggacguauagggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaacgauggcggcgcugucuccacccgagacucagugaaauugaaaucgcugugnagaugcaguguauccgcggcuagacggaaagaccccgunaaccuuuacuguagcuuugcacuggacuuugagccugcuuguguaggauaggugggaggcuuugaagcguggacgccaguucgcguggagccauccuugaaauaccacccuggcaugcuugagguucuaacucugguccguaauccggaucgaggacaguguauggugggcaguuugacugnggcggucuccuccuaaagaguaacggaggaguacgaaggugcgcucagaccggucggaaaucggucgcagaguauaaaggcaaaagcgcgcuugacugcgagacagacacgucgagcagguacgaaaguaggucuuagugauccggugguucuguauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaagccggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccguggacguuugagauuugagaggggcugcuccuaguacgagaggaccggaguggacgaaccucugguguuccgguugucacgccaguggcauugccggguagcuauguucggaaaagauaaccgcugaaagcaucuaagcgggaaacuugccucaagaugagaucucacugggaacuugauuccccugaagggccgucgaagacuacgacguugauaggcuggguguguaagcguugugaggcguugagcuaaccaguacuaauugcccgugaggcuugacca <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[[.(((.>>>.....<<<<<<<..<<<)))..]].>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...(((.....<<<<<<..<<<<<..<<<...<<<.<......>.>>>((......<<<.....))>>>...>>>....>>>>>..>>>>>>...........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<.....>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<.<<........>>.>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<..<<<<<<<<<.....<<<...<<<.<<<<...<<...<.......>....>>...>>>>.>>>..>>.>.....>>>>>>.>>>....>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........)))......>>>>>>.>>>...>>>>>>><<<<<<<.>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<...((((...>>>>>><<..<<<....<<<<<<<<<<<..<<.....>>.>>>>>>>..>>>>....>>>...>><..<<<<<<..>>>>>>...>>>>>>...>>>...>>>.>........>>>>...>>....>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<<<<<<<...<<<.....>>>....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.......<<<<<<.<<....>>..>>>>>>.......>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<.<............<<<<...<<...........<<<<....>>>>........>>.............>>>>...>.>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))))>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>...>>>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[[.[[[.))).....((((((...(((]]]..]].)))......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((....((((((..((((((.(((...(((.(......).)))[[(...).(((.....]])))...)))...))))))..))))))......)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((..).)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.((.((.......<)).)))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..(((((((((.....(((...(((.((((...((....(.....).....))...)))).)))..)).).....)))))).)))....))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((.(.(((..(((.........)))..))).....(..(((......)))).).)))...)))..))))).))...........]]].)....))))))))))...)))))))(((((((.)))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((..((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..(((....((((((((((((.((.....))))))))))..))))..[.)))...))(..((((((..))))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((...((((..)])))....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((((..((...((........[...(((((...(........(..(.((....)).)..).....)....]........)))))...))...))..))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))..).))))))))). Pseudomonas aeruginosa 70S ribosome initiation complex bound to compact IF2-GDP (composite structure I-B); 23S Ribosomal RNA 7unu B 117 2.9 RF00001 URS00005ACE34_208964 0003735 0005840 208964 gcuugacgaucauagagcguuggaaccaccugaucccuucccgaacucagaagugaaacgacgcaucgccgaugguaguguggggucuccccaugugagaguaggucaucgucaagc <<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<...>>>>>>>>.......>>>.>>>>>>>>>> (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((...)))))))).......)))..))))))))) Pseudomonas aeruginosa 70S ribosome initiation complex bound to compact IF2-GDP (composite structure I-B); 5S Ribosomal RNA 7unv a 1522 2.7 RF00177,RF01959,RF01960 URS00004149DE_208964 0003735 0005840 208964 gaacugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgagcggaugaagggagcuugcuccuggauucagcggcggacgggugaguaaugccuaggaaucugccugguagugggggauaacguccggaaacgggcgcuaauaccgcauacguccugagggagaaagugggggaucuucggaccucacgcuaucagaugagccuaggucggauuagcuaguuggugggguaaaggccuaccaaggcgacgauccguaacuggucugagaggaugaucagucacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauuggacaaugggcgaaagccugauccagccaugccgcgugugugaagaaggucuucggauuguaaagcacuuuaaguugggaggaagggcaguaaguuaauaccuugcuguuuugacguuaccaacagaauaagcaccggcuaacuucgugccagcagccncgguaauacgaagggugcaagcguuaaucggaauuacugggcguaaagcgcgcguaggugguucagcaaguuggaugugaaauccccgggcucaaccugggaacugcauccaaaacuacugagcuagaguacgguagagggugguggaauuuccuguguagcggugaaaugcguagauauaggaaggaacaccaguggcgaaggcgaccaccuggacugauacugacacugaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuagccguugggaucgaucuuaguggcgcagcuaacgcgauaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccuggccuugacaugcugagaacuuuccagagauggauuggugccuucgggaacucagacacaggugcugcauggcugucgucagcucgugucgugagauguuggguuaagucccguaacgagcgcaacccuuguccuuaguuaccagcaccucgggugggcacucuaaggagacugccggugacaaaccggaggaagguggggaugacgucaagucaucaugncccuuacggccagggcuacacacgugcuacaauggucgguacaaaggguugccaagccgcgagguggagcuaaucccauaaaaccgaucguaguccggaucgcagucugcaacucgacugcgugaagucggaaucgcuaguaaucgugaaucagaaugucacggugaauacguucccgggccuuguacacaccgnccgucacaccaugggaguggguugcuccagaaguagcuagucuaaccgcaagggggacgguuaccacggagugauucaugacuggggugaagucgnaacaagguagccguaggngnnccugcggcuggauc ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<....<<<<<<..>>>>>>....>>.>>>>>......<<.......<<<<<<<..<<...<<<<<<<<<.<<.....<<<<<<....>>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>>>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<<<<<<<<<<.......>>>>>>>>>>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<..<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>.>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<....<<<......>>>.......>>>>>>.>..........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<..>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<...<<<....>>>...>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((.....(((((..))))).....)).)))))......(((......(((((((..((...(((((((((.((.....((((((....))))))......)).).....((.(...)))....((((((..((....))))))))))))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(..((((((.(((.......))).))))))...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.((((((..((((((((((......((((((.....))))))....))))))))..)).))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((((())))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(...(((....)))...)...((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((.......(((..((...(((....)))...))....))).......)))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Pseudomonas aeruginosa 70S ribosome initiation complex bound to IF2-GDPCP (structure II-A); 16S Ribosomal RNA 7unv v 76 2.7 RF00005 URS000041AF00_562 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Pseudomonas aeruginosa 70S ribosome initiation complex bound to IF2-GDPCP (structure II-A); P-site initiator tRNA 7unv A 2884 2.7 RF02540,RF02541 URS00003C2204_208964 0003735 0005840 208964 ggucaagugaagaagcgcauacgguggaugccuuggcagucagaggcgaugaaagacgugguagccugcgaaaagcuucggggagucggcaaacagacuuugauccggagaucucugaaugggggaacccaccuaggauaaccuagguaucuuguacugaauccauaggugcaagaggcgaaccaggggaacugaaacaucuaaguacccugaggaaaagaaaucaaccgagauucccuuaguaguggcgagcgaacggggauuagcccuuaagcuucauugauuuuagcggaacgcucuggaaagugcggccauagugggugauagccccguacgcgaaaggaucuuugaagugaaaucgaguaggacggagcacgagaaacuuugucugaacauggggggaccauccuccaaggcuaaauacuacugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggagaggggagugaaauagaaccugaaaccguaugcguacaagcagugggagccuacuuguuaggugacugcguaccuuuuguauaaugggucagcgacuuauauucaguggcaagcuuaaccguauaggguaggcguagcgaaagcgagucuuaauagggcguuuagucgcuggguauagacccgaaaccgggcgaucuauccaugagcagguugaagguuagguaacacugacuggaggaccgaacccacucccnuugaaaagguaggggaugacuuguggaucggagugaaaggcuaaucaagcucggagauagcugguucuccucgaaagcuauuuagguagcgccucauguaucacucugggggguagagcacuguuucggcuagggggucaucccgacuuaccaaaccgaugcaaacuccgaauacccagaagugccgagcaugggagacacacggcgggugcuaacguccgucgugaaaagggaaacaacccagaccgccagcuaaggucccaaaguugugguuaagugguaaacgaugugggaaggcuuagacagcuaggagguuggcuuagaagcagccacccuuuaaagaaagcguaauagcucacuagucgagucggccugcgcggaagauguaacggggcucaaaccacacaccgaagcugcgggugucacggugacgcgguagaggagcguucuguaagccugugaaggugaguugagaagcuugcuggagguaucagaagugcgaaugcugacaugaguaacgacaaugggugugaaaaacacccacgccgaaagaccaaggguuccugcgcaacguuaaucgacgcaggguuagucgguuccuaaggcgaggcugaaaagcguagucgaugggaaacagguuaauauuccuguacuucugguuacugcgauggagggacggagaaggcuaggccagcuuggcguugguuguccaaguuuaaggugguaggcugaaaucuuagguaaauccgggguuucaaggccgagagcugaugacgagucgucuagaugacgaagugguugaugccaugcuuccaagaaaagcuucuaagcuucagguaaccaggaaccguaccccaaaccgacacngguggucggguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggcaccguaacuucgggagaaggugcgccggcuagggugaaggauuuacuccguaagcucuggcuggucgaagauaccaggccgcugcgacuguuuauuaaaaacacagcacucugcaaacacgaaaguggacguauagggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaacgauggcggcgcugucuccacccgagacucagugaaauugaaaucgcugugnagaugcaguguauccgcggcuagacggaaagaccccgunaaccuuuacuguagcuuugcacuggacuuugagccugcuuguguaggauaggugggaggcuuugaagcguggacgccaguucgcguggagccauccuugaaauaccacccuggcaugcuugagguucuaacucugguccguaauccggaucgaggacaguguauggugggcaguuugacugnggcggucuccuccuaaagaguaacggaggaguacgaaggugcgcucagaccggucggaaaucggucgcagaguauaaaggcaaaagcgcgcuugacugcgagacagacacgucgagcagguacgaaaguaggucuuagugauccggugguucuguauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaagccggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccguggacguuugagauuugagaggggcugcuccuaguacgagaggaccggaguggacgaaccucugguguuccgguugucacgccaguggcauugccggguagcuauguucggaaaagauaaccgcugaaagcaucuaagcgggaaacuugccucaagaugagaucucacugggaacuugauuccccugaagggccgucgaagacuacgacguugauaggcuggguguguaagcguugugaggcguugagcuaaccaguacuaauugcccgugaggcuugacca <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[[.(((.>>>.....<<<<<<<..<<<)))..]].>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...(((.....<<<<<<..<<<<<<.<<<...<<<.<......>.>>>((......<<<.....))>>>...>>>...>>>>>>..>>>>>>...........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<.....>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<.<<........>>.>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<..<<<<<<<<<.....<<<...<<<.<<<<...<<.<<.........>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>....>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<<.......<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>...>>>..>>>>>.>>...........)))......>>>>>>.>>>...>>>>>>><<<<<<<.>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<...((((...>>>>>><<..<<<....<<<<<<<<<<<..<<.....>>.>>>>>>>..>>>>....>>>...>><..<<<<<<..>>>>>>...>>>>>>...>>>...>>>.>........>>>>...>>....>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<<<<<<<...<<<.....>>>....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.......<<<<<<.<<....>>..>>>>>>.......>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<.<............<<<<...<<...........<<<<....>>>>........>>.............>>>>...>.>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))))>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<<<<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>...>>>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[[.[[[.))).....((((((...(((]]]..]].)))......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((....((((((..((((((.(((...(((.(......).)))[[(...).(((.....]])))...)))...))))))..))))))......)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((..).)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.((.((.......<)).)))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..(((((((((.....(((...(((.((((...((....(.....).....))...)))).)))..)).).....)))))).)))....))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{..((.(.(((..(((.........)))..))).....(..(((......)))).).))....)))..))))).))...........]]].)....))))))))))...)))))))(((((((.)))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((..((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..(((....(((.((((((((.((.....))))))))))...)))..[.)))...))(..((((((..))))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((...(((....])))....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((((..(((..((........[...((((....(.......((....((....))....))....)....].........))))...))..)))..))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))..).))))))))). Pseudomonas aeruginosa 70S ribosome initiation complex bound to IF2-GDPCP (structure II-A); 23S Ribosomal RNA 7unv B 117 2.7 RF00001 URS00005ACE34_208964 0003735 0005840 208964 gcuugacgaucauagagcguuggaaccaccugaucccuucccgaacucagaagugaaacgacgcaucgccgaugguaguguggggucuccccaugugagaguaggucaucgucaagc <<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<...>>>>>>>>.......>>>.>>>>>>>>>> (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((...)))))))).......)))..))))))))) Pseudomonas aeruginosa 70S ribosome initiation complex bound to IF2-GDPCP (structure II-A); 5S Ribosomal RNA 7unw a 1522 2.6 RF00177,RF01959,RF01960 URS00004149DE_208964 0003735 0005840 208964 gaacugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgagcggaugaagggagcuugcuccuggauucagcggcggacgggugaguaaugccuaggaaucugccugguagugggggauaacguccggaaacgggcgcuaauaccgcauacguccugagggagaaagugggggaucuucggaccucacgcuaucagaugagccuaggucggauuagcuaguuggugggguaaaggccuaccaaggcgacgauccguaacuggucugagaggaugaucagucacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauuggacaaugggcgaaagccugauccagccaugccgcgugugugaagaaggucuucggauuguaaagcacuuuaaguugggaggaagggcaguaaguuaauaccuugcuguuuugacguuaccaacagaauaagcaccggcuaacuucgugccagcagccncgguaauacgaagggugcaagcguuaaucggaauuacugggcguaaagcgcgcguaggugguucagcaaguuggaugugaaauccccgggcucaaccugggaacugcauccaaaacuacugagcuagaguacgguagagggugguggaauuuccuguguagcggugaaaugcguagauauaggaaggaacaccaguggcgaaggcgaccaccuggacugauacugacacugaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuagccguugggaucgaucuuaguggcgcagcuaacgcgauaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccuggccuugacaugcugagaacuuuccagagauggauuggugccuucgggaacucagacacaggugcugcauggcugucgucagcucgugucgugagauguuggguuaagucccguaacgagcgcaacccuuguccuuaguuaccagcaccucgggugggcacucuaaggagacugccggugacaaaccggaggaagguggggaugacgucaagucaucaugncccuuacggccagggcuacacacgugcuacaauggucgguacaaaggguugccaagccgcgagguggagcuaaucccauaaaaccgaucguaguccggaucgcagucugcaacucgacugcgugaagucggaaucgcuaguaaucgugaaucagaaugucacggugaauacguucccgggccuuguacacaccgnccgucacaccaugggaguggguugcuccagaaguagcuagucuaaccgcaagggggacgguuaccacggagugauucaugacuggggugaagucgnaacaagguagccguaggngnnccugcggcuggauc ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<....<<<<<<..>>>>>>....>>.>>>>>......<<.......<<<<<<<..<<...<<<<<<<<<.<<.....<<<<<<....>>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>>>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<<<<<<<<<<.......>>>>>>>>>>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<..<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>.>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<<..<<<......>>>.....>>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<..>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<...<<<....>>>...>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((.....(((((..))))).....)).)))))......(((......(((((((..((...(((((((((.((.....((.(((....))).))......)).).....(((....)))....((((((..((....))))))))))))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(..((((((.(((.......))).))))))...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.((((((..((((((((((......((((((.....))))))....))))))))..)).))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((((())))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(...(((....)))...)...((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...((((((......(((..((...(((....)))...))....)))......))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Pseudomonas aeruginosa 70S ribosome initiation complex bound to IF2-GDPCP (structure II-B); 16S Ribosomal RNA 7unw v 76 2.6 RF00005 URS000041AF00_562 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Pseudomonas aeruginosa 70S ribosome initiation complex bound to IF2-GDPCP (structure II-B); P-site initiator tRNA 7unw A 2884 2.6 RF02540,RF02541 URS00003C2204_208964 0003735 0005840 208964 ggucaagugaagaagcgcauacgguggaugccuuggcagucagaggcgaugaaagacgugguagccugcgaaaagcuucggggagucggcaaacagacuuugauccggagaucucugaaugggggaacccaccuaggauaaccuagguaucuuguacugaauccauaggugcaagaggcgaaccaggggaacugaaacaucuaaguacccugaggaaaagaaaucaaccgagauucccuuaguaguggcgagcgaacggggauuagcccuuaagcuucauugauuuuagcggaacgcucuggaaagugcggccauagugggugauagccccguacgcgaaaggaucuuugaagugaaaucgaguaggacggagcacgagaaacuuugucugaacauggggggaccauccuccaaggcuaaauacuacugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggagaggggagugaaauagaaccugaaaccguaugcguacaagcagugggagccuacuuguuaggugacugcguaccuuuuguauaaugggucagcgacuuauauucaguggcaagcuuaaccguauaggguaggcguagcgaaagcgagucuuaauagggcguuuagucgcuggguauagacccgaaaccgggcgaucuauccaugagcagguugaagguuagguaacacugacuggaggaccgaacccacucccnuugaaaagguaggggaugacuuguggaucggagugaaaggcuaaucaagcucggagauagcugguucuccucgaaagcuauuuagguagcgccucauguaucacucugggggguagagcacuguuucggcuagggggucaucccgacuuaccaaaccgaugcaaacuccgaauacccagaagugccgagcaugggagacacacggcgggugcuaacguccgucgugaaaagggaaacaacccagaccgccagcuaaggucccaaaguugugguuaagugguaaacgaugugggaaggcuuagacagcuaggagguuggcuuagaagcagccacccuuuaaagaaagcguaauagcucacuagucgagucggccugcgcggaagauguaacggggcucaaaccacacaccgaagcugcgggugucacggugacgcgguagaggagcguucuguaagccugugaaggugaguugagaagcuugcuggagguaucagaagugcgaaugcugacaugaguaacgacaaugggugugaaaaacacccacgccgaaagaccaaggguuccugcgcaacguuaaucgacgcaggguuagucgguuccuaaggcgaggcugaaaagcguagucgaugggaaacagguuaauauuccuguacuucugguuacugcgauggagggacggagaaggcuaggccagcuuggcguugguuguccaaguuuaaggugguaggcugaaaucuuagguaaauccgggguuucaaggccgagagcugaugacgagucgucuagaugacgaagugguugaugccaugcuuccaagaaaagcuucuaagcuucagguaaccaggaaccguaccccaaaccgacacngguggucggguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggcaccguaacuucgggagaaggugcgccggcuagggugaaggauuuacuccguaagcucuggcuggucgaagauaccaggccgcugcgacuguuuauuaaaaacacagcacucugcaaacacgaaaguggacguauagggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaacgauggcggcgcugucuccacccgagacucagugaaauugaaaucgcugugnagaugcaguguauccgcggcuagacggaaagaccccgunaaccuuuacuguagcuuugcacuggacuuugagccugcuuguguaggauaggugggaggcuuugaagcguggacgccaguucgcguggagccauccuugaaauaccacccuggcaugcuugagguucuaacucugguccguaauccggaucgaggacaguguauggugggcaguuugacugnggcggucuccuccuaaagaguaacggaggaguacgaaggugcgcucagaccggucggaaaucggucgcagaguauaaaggcaaaagcgcgcuugacugcgagacagacacgucgagcagguacgaaaguaggucuuagugauccggugguucuguauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaagccggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccguggacguuugagauuugagaggggcugcuccuaguacgagaggaccggaguggacgaaccucugguguuccgguugucacgccaguggcauugccggguagcuauguucggaaaagauaaccgcugaaagcaucuaagcgggaaacuugccucaagaugagaucucacugggaacuugauuccccugaagggccgucgaagacuacgacguugauaggcuggguguguaagcguugugaggcguugagcuaaccaguacuaauugcccgugaggcuugacca <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[[.(((.>>>.....<<<<<<<..<<<)))..]].>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...(((.....<<<<<<..<<<<<..<<<...<<<.<......>.>>>((......<<<.....))>>>...>>>....>>>>>..>>>>>>...........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<.....>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<.<<........>>.>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<..<<<<<<<<<.....<<<...<<<.<<<<...<<................>>...>>>>.>>>..>>.>.....>>>>>>.>>>....>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<........>>..>>>>>....>>..>>>>>.>>...........)))......>>>>>>.>>>...>>>>>>><<<<<<<.>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<...((((...>>>>>><<..<<<....<<<<<<<<<<<..<<.....>>.>>>>>>>..>>>>....>>>...>><..<<<<<<..>>>>>>...>>>>>>...>>>...>>>.>........>>>>...>>....>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<<<<<<<...<<<.....>>>....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.......<<<<<<.<<....>>..>>>>>>.......>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<.<............<<<<...<<............<<<....>>>.........>>.............>>>>...>.>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))))>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<<<<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>...>>>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[[.[[[.))).....((((((...(((]]]..]].)))......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((....((((((..((((((.(((...(((.(......).)))[[(...).(((.....]])))...)))...))))))..))))))......)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((..).)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.((.((.......<)).)))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..(((((((((.....(((...(((.((((...((..(.(.....)...).))...)))).)))..)).).....)))))).)))....))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{..((.(.(((..(((.........)))..))).....(..((........))).).))....)))..))))).))...........]]].)....))))))))))...)))))))(((((((.)))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((..((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..(((....(((.((((((((.((.....))))))))))...)))..[.)))...))(..((((((..))))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((...((((..)])))....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((((..((...((........[...((((....(........(...(((....)))...).....)....].........))))...))...))..))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))..).))))))))). Pseudomonas aeruginosa 70S ribosome initiation complex bound to IF2-GDPCP (structure II-B); 23S Ribosomal RNA 7unw B 117 2.6 RF00001 URS00005ACE34_208964 0003735 0005840 208964 gcuugacgaucauagagcguuggaaccaccugaucccuucccgaacucagaagugaaacgacgcaucgccgaugguaguguggggucuccccaugugagaguaggucaucgucaagc <<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<...>>>>>>>>.......>>>.>>>>>>>>>> (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((...)))))))).......)))..))))))))) Pseudomonas aeruginosa 70S ribosome initiation complex bound to IF2-GDPCP (structure II-B); 5S Ribosomal RNA 7uo0 B 373 3.4 RF00010 URS0000803A36_562 36045135 3.1.26.5 0004526 0008033 0030680 562 gaagcugaccagacagucgccgcuucgucgucguccucuucgggggagacgggcggaggggaggaaaguccgggcuccauagggcagggugccagguaacgccugggggggaaacccacgaccagugcaacagagagcaaaccgccgauggcccgcgcaagcgggaucagguaagggugaaagggugcgguaagagcgcaccgcgcggcugguaacaguccguggcacgguaaacuccacccggagcaaggccaaauagggguucauaagguacggcccguacugaacccggguaggcugcuugagccagugagcgauugcuggccuagaugaaugacuguccacgacagaacccggcuuaucggucaguuuc <<<.<<<<<<...((((..<<.<<<<<.<<<<..<<<.<...>>>>.>>>>..>>>>>.>>........<<<<<<<..........<.<<.<<<<.......>>>>..<......>..................................<<<<........>>>.>.................<.<<.........>>.>...<<<<<<<....>>>.>>>>...............>>.>..>>...<<<............................................>>>......<<<<<<........>>>>>>...........))))............>>>>>......>>>>>>.>>> (((.(((.((...[[[...((.((.((.((((.(((((....)))))))))..)).)).)).{....(.((((((..(...[.[..(((((.(((.......))).(((......)).)......................(..(....(((((((....))))).))..)....).......((.((.........)).))((.((((((....))).))).).)...........))))).).)....(((......((((((.....((((..].])))).)))))).....))).......(((((..(....)..)))))............]]].......}....)))))).....)).))).))) E.coli RNaseP Holoenzyme with Mg2+; RNase P RNA 7uo0 C 82 3.4 RF00005 URS000261771D_562 36045135 0030533 0006412 562 ucuggggcuacguagcucaguugguuagagcacaucacucauaaugauggggucacagguucgaaucccgucguagccacca .....<<<<<<...<<<<.........>>>>.<<<<.........>>>>.....<<.............>>.>>>>>>.... .....((((((([.((((.]...[...)))).((((.........)))).....((.((..]....)).))))))))).... E.coli RNaseP Holoenzyme with Mg2+; Precursor tRNA substrate G(-1) G(-2) 7uo1 B 373 3.2 RF00010 URS0000803A36_562 36045135 3.1.26.5 0004526 0008033 0030680 562 gaagcugaccagacagucgccgcuucgucgucguccucuucgggggagacgggcggaggggaggaaaguccgggcuccauagggcagggugccagguaacgccugggggggaaacccacgaccagugcaacagagagcaaaccgccgauggcccgcgcaagcgggaucagguaagggugaaagggugcgguaagagcgcaccgcgcggcugguaacaguccguggcacgguaaacuccacccggagcaaggccaaauagggguucauaagguacggcccguacugaacccggguaggcugcuugagccagugagcgauugcuggccuagaugaaugacuguccacgacagaacccggcuuaucggucaguuuc .<<<<<<<<<.<<<<<<<.<<.<<<<<<<<<<..<<<......>>>.>>>>.>>>>>>.>>.{...[[.(((((((.....<<<<.<<<<<<<<<<.....>>>>>.<<......>>..<<.....<..............<...........<<<....>>>.............>......<<<<<.........>>>>>......<<......>>............>....>>>>>>>..))...((((.......[[........((((.>>>>))))....]]......))))......<<<<<<<<....>>>>>>>>..........>>>>>>>.....}....)))))]]....>>>>>>>>>. ..(.((((((.(((((...((.((((((((((.(((.(....).))))))).)))))).)).{...[[.[[[[[(..(...[[[..((((((.(((.....))).).((......))..(.................................(((....)).)...................((.((.........)).)).....(...(...)....)...............)))))))..)...((((..................(((..]]]))).............))))....(.(((((.((....)).))))))...........))))).....}....]]]]]]]....)))))).).. E.coli RNaseP Holoenzyme with Mg2+; E.coli RNase P RNA 7uo1 C 82 3.2 RF00005 URS000261773C_562 36045135 0030533 0006412 562 ucuauggcuacguagcucaguugguuagagcacaucacucauaaugauggggucacagguucgaaucccgucguagccacca .....<<<<<<<..<<<<.........>>>>.<<<<.........>>>>.....<<.<<.......>>.>>>>>>>>>.... .....(((((((..((((.....[...)))).((((.........)))).....((.((..]....)).))))))))).... E.coli RNaseP Holoenzyme with Mg2+; Precursor tRNA substrate U(-1) and A(-2) 7uo4 P 34 3.38 URS000261779E_32630 36725929 32630 gcguagcaugcuacgucauucuccuaagaagcug .................................. .................................. SARS-CoV-2 replication-transcription complex bound to Remdesivir triphosphate, in a pre-catalytic state; Product RNA (35-MER) 7uo4 T 36 3.38 URS00026177A0_32630 36725929 32630 cucagcuucuuaggagaaugacguagcaugcuacgc .................................... .................................... SARS-CoV-2 replication-transcription complex bound to Remdesivir triphosphate, in a pre-catalytic state; Template RNA (55-MER) 7uo7 P 32 3.09 URS000261779E_32630 36725929 32630 guagcaugcuacgucauucuccuaagaagcug ................................ ................................ SARS-CoV-2 replication-transcription complex bound to ATP, in a pre-catalytic state; Product RNA (35-MER) 7uo7 T 34 3.09 URS00026177A0_32630 36725929 32630 cucagcuucuuaggagaaugacguagcaugcuac .................................. .................................. SARS-CoV-2 replication-transcription complex bound to ATP, in a pre-catalytic state; Template RNA (55-MER) 7uo9 P 32 3.13 URS0002617797_32630 36725929 32630 guagcaugcuacgucauucuccacgcgaagcn ................................ ................................ SARS-CoV-2 replication-transcription complex bound to UTP, in a pre-catalytic state; Product RNA (35-MER) 7uo9 T 35 3.13 URS00026177A3_32630 36725929 32630 ucaugcuucgcguggagaaugacguagcaugcuac ................................... ................................... SARS-CoV-2 replication-transcription complex bound to UTP, in a pre-catalytic state; Template RNA (55-MER) 7uob P 33 2.68 URS0002617797_32630 36725929 32630 cguagcaugcuacgucauucuccacgcgaagca ................................. ................................. SARS-CoV-2 replication-transcription complex bound to GTP, in a pre-catalytic state; Product RNA (35-MER) 7uob T 36 2.68 URS00026177A3_32630 36725929 32630 ucaugcuucgcguggagaaugacguagcaugcuacg .................................... .................................... SARS-CoV-2 replication-transcription complex bound to GTP, in a pre-catalytic state; Template RNA (55-MER) 7uoe P 33 2.67 URS0002617797_32630 36725929 32630 cguagcaugcuacgucauucuccacgcgaagca ................................. ................................. SARS-CoV-2 replication-transcription complex bound to CTP, in a pre-catalytic state; Product RNA (35-MER) 7uoe T 37 2.67 URS000261779D_32630 36725929 32630 gugaugcuucgcguggagaaugacguagcaugcuacg ..................................... ..................................... SARS-CoV-2 replication-transcription complex bound to CTP, in a pre-catalytic state; Template RNA (55-MER) 7uoo 1 2991 2.34 RF02543 URS000061F377_1247190 36864048 0003735 0005840 1247190 guuugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacnnggaccaaggagunuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccnanagauggugancuaugccugaauagggugaagccagaggaaacucugguggaggcucguancgguucugncgugcaaaucgaucgucgaaunuggguauagnggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugaguguaagaaguccuuguuugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcngaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaunuuggugguagunncaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaanguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauunaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugccnagugcucugaaugucaaagugangaaauucaaccaagcgcggguaaacggcgggaguacucucuuaagguagcnaauggauuaacgagauucccacugunccuaucuacnaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcungacncuaguuugacauugugaagagacauaguuucuuuacuuauucaaugaagcggagcuggauccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauunucagngugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuanangugccagaaaaguuaccacagngauaacuggcuuguggcagucaagcguuauagcgacauugcuuuuugauungaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggaunnuucacccacuaauagggaacggnuggguuuagancgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagcguuacgaucugcugagauuaagccuuuguugucugauuugu ..........................<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<.<<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>>..>>>>>>>....>>>>>>>>>>>........<<<<<<<.<....>.>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<......<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<......>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<......>...>>>>.>>.>>....>>>>>>.>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<......<<<....>>>..<<<<<<<<<<...<<<.<<<<<<<..>>>>>...<<<<.<<<....>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<......<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>....>>>>>>.>>>>..>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>...<...<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>...>......>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<..>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>.......<<<..<<<<<<.....<<.....<<<<....>>>>.....>>..>>>>..>>>>><<<<<..>>>>>..........<<.>>......>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..[[[........(((((([[[.[[..<<<<<.<<<<<<<<..<<<<<<<<<.....>>>>>>>>>...<<<<<.....<<<<...<<..>>................<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>.......<<<<<<.<<..>>.>>..<<<<<<<...<<<<<<.......>>>>>>.....<<......>>....>>>>>>>....<<<<.<.<<<.....>>>.>>>>><<<<....>>>.>>>>>.[[...[[.((((..((((.>>>>>>)))))))).]].....]]..]]]]]..)))))).............<<<<<<...<<......>>...>>>>>>.............<<<<<..<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>...>>>>>.....<<<<<<<....>>>.>>>>........]]].]]]]]....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>........<<<<<.<<<.......<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>...............>>.>.>>>.>>..<<<<<<<.............>.....<<<<<<<<<.<<<....<<<<....<<<<..>>>>...>>>>...>>>....>>>>.>>>>>.>>>>>>.. ..........................(((((......((....)).......)))).).........((....))...((((......((.....)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((.((.((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..)))).)).....)))))))))))...)....(((((((.(....).))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((......((((........)))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).<((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))..).))))))))).(.((.....B.))...)..))))))......).))).((((((......((([...)))..(((.((((((...(((.(.(((.(..).)))...((((..((....))..))))......)))).)))))).).))..((((.((.((.....)).)).))))....(((......)))...(((((((...((([[[...(.((((((......(....A.....(((.((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((....)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((..((((((....((.....))..)))))....[[(((.((...((....(((....)))........((((((........))))))....))....))...(((((........)))))]]((((..(((((((...((((....)))...(.[.((((((...((((.((((((((((((((((((..{{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((.(......).))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).))).))).....((......)).)))).((((.....))))..))))..(.(......((((((..((..(....(.......(((((....(.[..).....)))))((.(((((((((((..)))))..)))))).))(...).......(((((((.(.>.((.........))...(((((((....((((.....))))......))))))).].....((...((((.(.....(......((((....))))......)..).))..)).))(.(.(()).).)..........(...)......)..))))))).)..)))..))))))...).)))....)).[..(((((.....>].)))))....(((((..(((.(......(((((((((.(...(((((.(.((((((..(((((((((.....)))))))))....((((.....((((..(((())))...........]...((((((....))))))..))))..))))......)))))).)..)))))...]...((((.(...()...)...(((((((.(.((((((.......))))))...).((......))....)))))))....((((.(.(((.....))).)))))((((....))).))))).((....(..(((..((((.]]]]]])))))))..)......))...))))b.)))))).......a[....((((((...((......))...))))))..............((((..(((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..])))).......((((((....))).)))...a..)..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}}.)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......(.((((.(((.......((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).))))))...............)).).))).))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(((.().)))..)))))...)))....)))).)))))).))))).. Nucleoplasmic pre-60S intermediate of the Nog2 containing pre-rotation state; 25S rRNA 7uoo 2 158 2.34 RF00002 URS00001BF64E_1247190 36864048 0003735 0005840 1247190 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Nucleoplasmic pre-60S intermediate of the Nog2 containing pre-rotation state; 5.8S rRNA 7uoo 6 58 2.34 URS000268138E_1247190 36864048 1247190 ccuucucaaacauguuugguagugagugauacucgaguuaacuugaaauugccuuaaa ......<<<<<..>>>>>.....<<<<.<.<<<..>>>>.>>>>.............. .......((((())))).....(((((...(((())))..))))..)........... Nucleoplasmic pre-60S intermediate of the Nog2 containing pre-rotation state; ITS2 rRNA 7uph I 4438 4.18 RF02541 URS000234A4AC_562 35836020,31588918 0003735 0005840 562 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Structure of a ribosome with tethered subunits; Tethered rRNA 7uph J 118 4.18 RF00001 URS0000366A67_562 35836020,31588918 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<........<<<<<<.....<<.<<...............>>...>>....>>>>>>....<<.......<<<<<<<<...>>>>>>>>.......>>....>>>>>>>>. (((((((.(.....((.(((.(......(..(....(.....)....)....).....).)))..)).((.......((.(((((...))))).)).......))...).))))))). Structure of a ribosome with tethered subunits; 5S rRNA 7uqb 1 2991 2.43 RF02543 URS000061F377_1247190 36864048 0003735 0005840 1247190 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..........................<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..<<<..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<.<<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>>..>>>>>>>....>>>>>>>>>>>........<<<<<<<.<....>.>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<......<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<......>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<......>...>>>>.>>.>>....>>>>>>.>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<......<<<{{..>>>..<<<<<<<<<<...<<<.<<<<<<<..>>>>>...<<<<.<<<....>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>...<...<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..[[[..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>...>......>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<..>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>.......<<<..<<<<<<.....<<.....<<<<....>>>>.....>>..>>>>..>>>>><<<<<..>>>>>..........<<.>>......>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<........<<<<<<<<<.<<..<<<<<.<<<<<<<<..<<<<<<<<<.....>>>>>>>>>...<<<<<.....<<<<...<<..>>................<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>..}}...<<<<<<.<<..>>.>>..<<<<<<<...<<<<<<.......>>>>>>.....<<......>>....>>>>>>>....<<<<.<.<<<.....>>>.>>>>>.<<<....>>>..>>>>.<<...<<<<<<<..<<<<.))))))>>>>>>>>>>>.....>>..>>>>>..>>>>>>.............<<<<<<...<<......>>...>>>>>>.............<<<<<..<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>...>>>>>.....<<<<<<<....>>>.>>>>........>>>.>>>>>....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<....<<<<<<<<<<]]].>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>........<<<<<...<.......<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>...............>....>>>>.>..<<<<<<<.............>.....<<<<<<<<<.<<<....<<<<....<<<<..>>>>...>>>>...>>>....>>>>.>>>>>.>>>>>>.. ..........................(((((......((....)).......)))).).........((....))...((((......((.....)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((.(..((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))..).....)))))))))))...)....(((((((.(....).))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((......((((........)))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).<((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))..).))))))))).(.((.....B.))...)..))))))......).))..((((((......((([...)))..((..((((((...(((.(.(((.(..).)))...((((..((....))..))))......)))).))))))...))..((((.((.((.....)).)).))))....(((......)))...(((((((...((([[[...(.((((((......(....A.....(((.((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((....)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((..((((((....((.....))..)))))....[[(((.((...((....(((....)))........((((((........))))))....))....))...(((((........)))))]]((((..(((((((...((((....)))...(.[.((((((...((((.((((((((((((((((((..{{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((.(......).))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).))).))).....((......)).)))).((((.....))))..))))..(.(......((((((..((..(....(.......(((((....(.[..).....)))))((.(((((((((((..)))))..)))))).))(...).......(((((((.(.>.((.........))...(((((((....((((.....))))......))))))).].....(((..((.(.(.....((.....(((......))).....))..).)...)))))(.(.(()).).)..........(...)......)..))))))).)..)))..))))))...).)))....)).[..(((((.....>].)))))....(((((..(((.(......(((((((((.(...(((((.((((((((..(((((((.(.....).)))))))....((((.....((((..(((())))...........]...((((((....))))))..))))..))))......))))))))..)))))...]...((((.(...()...)...(((((((.(.((((((.......))))))...).((......))....)))))))....((((.(.(((.....))).)))))((((....))).))))).((...((.((((..((((.]]]]]])))))))).)).....))...))))b.)))))).......a[....((((((...((......))...))))))..............((((..(((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..])))).......((((((....))).)))...a..)..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}}.)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......(.(((..((........((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).))))))................).)..)).))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(((.().)))..)))))...)))....)))).)))))).))))).. Nucleoplasmic pre-60S intermediate of the Nog2 containing pre-rotation state from a SPB1-D52A strain with AlF4; 25S rRNA 7uqb 2 158 2.43 RF00002 URS00001BF64E_1247190 36864048 0003735 0005840 1247190 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<<<<....>>>>.....<.<<<......>>..............>>>..>...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Nucleoplasmic pre-60S intermediate of the Nog2 containing pre-rotation state from a SPB1-D52A strain with AlF4; 5.8S rRNA 7uqb 6 58 2.43 URS00026813B0_1247190 36864048 1247190 ccuucucaaacauguuugguagugagugauacucgaguuaacuugaaauugccuuaaa ......<<<<<..>>>>>.....<<<<.<.<<<..>>>>.>>>>.............. .......((((())))).....(((((...(((())))..))))..)........... Nucleoplasmic pre-60S intermediate of the Nog2 containing pre-rotation state from a SPB1-D52A strain with AlF4; ITS2 rRNA 7uqz 1 2986 2.44 RF02543 URS000061F377_1247190 36864048 0003735 0005840 1247190 guuugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacnnggaccaaggagunuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccnanagauggugancuaugccugaauagggugaagccagaggaaacucugguggaggcucguancgguucugncgugcaaaucgaucgucgaaunuggguauagnggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugaguguaagaaguccuuguuugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcngaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaunuuggugguagunncaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaanguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauunaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugccnagugcucugaaugucaaagugangaaauucaaccaagcgcggguaaacggcgggaguacucucuuaagguagcnaauggauuaacgagauucccacugunccuaucuacnaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcungacncuaguuugacauugugaagagacauaguuucuuuacuuauucaaugaagcggagcuggauccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauunucagngugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuanangugccagaaaaguuaccacagngauaacuggcuuguggcagucaagcguuauagcgacauugcuuuuugauungaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauacccacuaauagggaacggnuggguuuagancgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagcguuacgaucugcugagauuaagccuuuguugucugauuugu ..........................<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<.<<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<.<....>.>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<......<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<......>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<......>...>>>>.>>.>>....>>>>>>.>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<......<<<....>>>..<<<<<<<<<<...<<<.<<<<<<<..>>>>>...<<<<.<<<....>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>...<...<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>...>......>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<..>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>.......<<<..<<<<<<.....<<.....<<<<....>>>>.....>>..>>>>..>>>>><<<<<..>>>>>..........<<.>>......>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..[[[........(((((([[[.[[..<<<<<.<<<<<<<<..<<<<<<<<<.....>>>>>>>>>...<<<<<.....<<<<...<<..>>................<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>.......<<<<<<.<<..>>.>>..<<<<<<<...<<<<<<.......>>>>>>.....<<......>>....>>>>>>>....<<<<.<.<<<.....>>>.>>>>><<<<....>>>.>>>>>.[[...[[.((((..((((.>>>>>>)))))))).]].....]]..]]]]]..)))))).............<<<<<<...<<......>>...>>>>>>.............<<<<<..<<<<<..<.<<<<<<<......>>>>>>>...>.<<<....>>>.....>>>>>...>>>>>.....<<<<<<<....>>>.>>>>........]]].]]]]]....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<.<<<<.<.<.......<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>...............>..>.>>>.>>..<<<<<<<.............>.....<<<<<<<<<.<<<....<<<<....<<<<..>>>>...>>>>...>>>....>>>>.>>>>>.>>>>>>.. ..........................(((((......((....)).......)))).).........((....))...((((......((.....)).....))))...((((.........(((.((((((...)))))).))....)........((((((.((((((((.(((.((((((((...({((((......)))))[[(...).(((....}]])))....))))))))...))).)))....)))))))))))...)....(((((((.(....).))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((......((((........)))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).<((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))..).))))))))).(.((.....B.))...)..))))))......).))).((((((......((([...)))..(((.((((((...(((.(.(((.(..).)))...((((..((....))..))))......)))).)))))).).))..((((.((.((.....)).)).))))....(((......)))...(((((((...((([[[...(.((((((......(....A.....(((.((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((....)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((..((((((....((.....))..)))))....[[(((.((...((....(((....)))........((((((........))))))....))....))...(((((........)))))]]((((..(((((((...((((....)))...(.[.((((((...((((.((((((((((((((((((..{{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((.(......).))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).))).))).....((......)).)))).((((.....))))..))))..(.(......((((((..((..(....(.......(((((....(.[..).....)))))((.(((((((((((..)))))..)))))).))(...).......(((((((.(.>.((.........))...(((((((....((((.....))))......))))))).].....(((..((((.(.....(......((((....))))......)..).))..)))))(.(.(()).).)..........(...)......)..))))))).)..)))..))))))...).)))....)).[..(((((.....>].)))))....(((((..(((.(......(((((((((.(...(((((.((((((((..(((((((.(.....).)))))))....((((.....((((..(((())))...........]...((((((....))))))..))))..))))......))))))))..)))))...]...((((.(...()...)...(((((((.(.((((((.......))))))...).((......))....)))))))....((((.(.(((.....))).)))))((((....))).))))).((....(..(((..((((.]]]]]])))))))..)......))...))))b.)))))).......a[....((((((...((......))...))))))..............((((..(((((..(.(((((((......))))))..).).(((.().))).....)))))..])))).......((((((....))).)))...a..)..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}}.)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......(.((((.((........((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).))))))................).).))).))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(((.().)))..)))))...)))....)))).)))))).))))).. Nucleoplasmic pre-60S intermediate of the Nog2 containing pre-rotation state from a SPB1 D52A strain; 25S rRNA 7uqz 2 158 2.44 RF00002 URS00001BF64E_1247190 36864048 0003735 0005840 1247190 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Nucleoplasmic pre-60S intermediate of the Nog2 containing pre-rotation state from a SPB1 D52A strain; 5.8S rRNA 7uqz 6 58 2.44 URS00026813B0_1247190 36864048 1247190 ccuucucaaacauguuugguagugagugauacucgaguuaacuugaaauugccuuaaa ......<<<<<..>>>>>.....<<<<.<.<<<..>>>>.>>>>.............. .......((((())))).....(((((...(((())))..))))..)........... Nucleoplasmic pre-60S intermediate of the Nog2 containing pre-rotation state from a SPB1 D52A strain; ITS2 rRNA 7uu3 C 11 3.099 URS000268136E_32630 36470880 32630 cccacgggaau ........... ........... Crystal structure of APOBEC3G complex with 3'overhangs RNA-Complex; RNA (5'-R(*CP*CP*CP*AP*CP*GP*GP*GP*AP*AP*U)-3') 7uu3 D 11 3.099 URS0002681380_32630 36470880 32630 cccgugggaau ........... ........... Crystal structure of APOBEC3G complex with 3'overhangs RNA-Complex; RNA (5'-R(*CP*CP*CP*GP*UP*GP*GP*GP*AP*AP*U)-3') 7uu5 M 11 2.9 URS0002681383_32630 36470880 32630 uaacgcugcgg ........... ........... Crystal structure of APOBEC3G complex with 5'-Overhang dsRNA; RNA (5'-R(P*UP*AP*AP*CP*GP*CP*UP*GP*CP*GP*G)-3') 7uu5 N 11 2.9 URS000268137C_32630 36470880 32630 uaaccgcagcg ........... ........... Crystal structure of APOBEC3G complex with 5'-Overhang dsRNA; RNA (5'-R(P*UP*AP*AP*CP*CP*GP*CP*AP*GP*CP*G)-3') 7uvv A 2724 2.5 RF02541 URS000231197A_480119 37192172 0003735 0005840 480119 gucaaguaauuaagugcaugugguggaugccuuggcagucagaggcgaugaaagacgugauagccugcgaaaagcuccggggaggcggcaaauauccuuugauccggagaugucugaaugggggaacccaccuacuuuaagguagguauugcaacaugaauacauaguguugcaaggcgaacgaggggaagugaaacaucucaguacccuuaggaaaagaaaucaauugagauucccucaguagcggcgagcgaacggggaucagcccauuaaguuauguguguuuuaguggaacgcucugggaagugcgaacguagagggugauauucccguacacgaaagggcacacauaaugaugacgaguagggcgaggcacgugaaaccuugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccugugaggggagugaaauagauccugaaaccgcaugcauacaagcagugggagcaccuucguggugugacugcguaccuuuuguauaaugggucagcgacuuauauucaguagcgagguuaaccguauaggggagccguagagaaaucgagucuuaauagggcguuuaguugcuggguauagacccgaaaccaggcgaucuauccaugagcagguugaagguuggguaacacuaacuggaggaccgaacccacugucguugaaaagccaggggaugacuuguggauaggggugaaaggcuaaucaagccuggugauagcugguucuccccgaaagcuauuuagguagcgccucggacgaauaccauaggggguagagcacuguuucggcaccgaugcaaacuccgaauaccuaugaguacuauccgggagacagacugcgggugcuaacguccguagucaagaggaaaacaauccagaccgccagcuaaggccccaaaaucauaguuaagugggaaacgaugugggaaggcauagacagcuauagucgagucggccugcgcggaagauguaacggggcuaaaacuaugugccgaagcugcggauguauacuuuguauacgugguaggggagcguucuguaagccgaugaagguguguugagaagcaugcuggagguaucagaagugcgaaugcugacgugaguaacgacaaaacgggugaaaaacccguucgccgaaagaccaaggguuccaguccaacguuaaucggggcugggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaaaugguuaauauuccauuacuucuguguaaugcgaugagaggacggagaaggcuaaaucagccuggcguugguuguccaggugaaaggauguaggcauguaucuuaggcaaauccgggguacucuaugcugagaucugauagcaagcuguacuugugcagcgaagugguugaugccaugcuuccaggaaaagucucuaagcuucaguuacacaggaaucguacccgaaaccgacacagguggucaggucgaguagaccaaggcgcuugagagaacucugcugaaggaacuaggcaaaaugguaccguaacuucgggagaagguacgcuguuguuggugauggaacucgcuuccugagcugacgacagccgcagaaaccaggccgcugcaacuguuuauuaaaaacauagcacucugcaaacacgaaaguggacguauagggugugaugccugcccggugcuggaagguuaauugaugggguuagcguaagcgaagcucuugaucgaagccccaguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgaccugcacgaauggcauaaugauggcggcgcugucuccagcagaggcucagugaaaucgaaaucgcugugnagaugcaguguacccgcggcuagacggaaagaccccgunaaccuuuacugcagcuugacacugaacuuagguucuaacucugucccgugauccgggacgaggaccgugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggaguacgaaggugcgcucagcguggucggaaaucacgcguagaguauaaaggcaaaagcgcgcuuaacugcgagacccacaagucgagcagguacgaaaguaggucuuagugauccggugguucuguauggaagggccaucgcucaacggauaaaagguacucugnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgnugucggcucaucucauccuggggcugaagcaggucccaaggguauggcnguucgccauuuaaagagguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucuaccgugggcgcuggaaauuugagaggaucugcuccuaguacgagaggaccagaguggacgaaccucugguguaccgguugugacgccagucgcaucgccggguagcuauguucggaagggauaaccgcugaaagcaucuaagcgggaagccuaccucaagauaagauuucccuaggacuuuauguccucuaaagagccguucgagacuaggacguugauagguuggauguggaagcauagugauaugugaagcugaccaauacuaauugcucgugaggcuugacu <<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<.)))......>>.....>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<<..>>>...<<<<<.....<<.....>>....>>>>>...<<<......<<<<<<<<<<<<<<.<<<...<<<.<......>.>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>...........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..>>>......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<.....>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<.<........>.>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<....<<<<<<<<<.....<<<...<<<.<<<<..>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<..>>>....>>..>>>>>.>>...........)))......>>>>>>.>>>...>>>>>>><<<<<<<<...>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<...((((...>>>>>>....<<<<...<<<<.<<<<<<..<<.....>>.>>>>>>....>>>>...>>>>........<<<<<<....>>>>>>....>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<<<<<<<...<<<<.....>>>>...>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.......<<<<<..<<....>>...>>>>>.......>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<.<<<<.[[......<<<<.[[<<<<..<<<<..<<<.<<<<<.<<<<<..>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>...>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<.................>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))))>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<<<<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>...>>>>..>..>>>>>>>. ((((((([.....((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...((.]]]...]..))......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.....((((((((((((((.(((...(((.(......).)))[[(...).(((.....]])))...)))...))))))))))))))......)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((.....)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((.(.......<).))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).(((((((...((((((((((.....(((...(((.((((..)))).)))..)).).....)))))).))).).)))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{....()......)))..))))).))...........]]].)....))))))))))...)))))))((((((((...))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))....((((...(.((...(((((.((.....)))))))......)).)..[))))........((((.(....).))))....)))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((...((((....]))))...))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..(((((((..(((.((......(((..((((((..(((((.(((.(((((.((((.().))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..)).)))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(.(((((....))).)).)..>.))..))).)))))))[...(((((((...((((..((((((......(....).....)))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..)])))))(....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))..).)))))))). A. baumannii ribosome-Streptothricin-F complex: 70S with P-site tRNA; 23s ribosomal RNA 7uvv B 115 2.5 RF00001 URS00002D8B10_480119 37192172 0003735 0005840 480119 gcuggcgaccauagcaagagugaaccaccugaucccuucccgaacucagaagugaaaccucuuagcgcugaugguagugugggauuacccaugugagaguaagucaucgccagcu <<<<<<<<.....<<<<<<<.....<<<<<<<.............>>>>..>>>....>>>>>.>><<<.......<<<<<<<....>>>>>>>.......>>>..>>>>>>>>. ((((((((.....(((((((.....(((((((...(.....)...))))..)))....))))).))(((.......(((((((....))))))).......)))..)))))))). A. baumannii ribosome-Streptothricin-F complex: 70S with P-site tRNA; 5s ribosomal RNA 7uvv a 1528 2.5 RF00177,RF01959,RF02542,RF01960 URS00023119FB_480119 37192172 0003735 0005840 480119 uaacugaagaguuugaucauggcucagauugaacgcuggcggcaggcuuaacacaugcaagucgagcgggggaagguagcuugcuaccggaccuagcggcggacgggugaguaaugcuuaggaaucugccuauuagugggggacaacaucucgaaagggaugcuaauaccgcauacguccuacgggagaaagcaggggaucuucggaccuugcgcuaauagaugagccuaagucggauuagcuaguuggugggguaaaggccuaccaaggcgacgaucuguagcgggucugagaggaugauccgccacacugggacugagacacggcccagacuccuacgggaggcagcaguggggaauauuggacaauggggggaacccugauccagccaugccgcgugugugaagaaggccuuaugguuguaaagcacuuuaagcgaggaggaggcuacucuaguuaauaccuagggauaguggacguuacucgcagaauaagcaccggcuaacucugugccagcagccncgguaauacagagggugcgagcguuaaucggauuuacugggcguaaagcgugcguaggcggcuuauuaagucggaugugaaauccccgagcuuaacuugggaauugcauucgauacuggugagcuagaguaugggagaggaugguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgauggcgaaggcagccaucuggccuaauacugacgcugagguacgaaagcauggggagcaaacaggauuagauacccugguaguccaugccguaaacgaugucuacuagccguuggggccuuugaggcuuuaguggcgcagcuaacgcgauaaguagaccgccuggggaguacggucgcaagacuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggccuugacauacuagaaacuuuucagagauggauuggugccuucgggaaccuagauacaggugcugcauggcugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuuuuccuuacuugccagcauuucggaugggaacuuuaaggauacugccagugacaaacuggaggaaggcggggacgacgucaagucaucaugncccuuacggccagggcuacacacgugcuacaauggucgguacaaaggguugcuacacagcgaugugaugcuaaucucaaaaagccgaucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucgcggaucagaaugccgcggugaauacguucccgggccuuguacacaccgnccgucacaccaugggaguuuguugcaccagaaguagcuagccuaacugcaaagagggcgguuaccacgguguggccgaugacuggggugaagucgnaacaagguagccguaggggnnccugcggcuggauc ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<<...<<<<<<..>>>>>>...>>>.>>>>>......<<.......<<<<<<<..<<...<<<<<<<<<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>>>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<<<<<<<<<<.<...>.>>>>>>.>>>>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<<...>>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<...<..<<<<....>>>>..>...<<....>>...>>>>.>>.<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<<..<<<.....>>>>>.....>>>>>>.....<<<<<.....>>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<.<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>.>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((...((((((..))))))...))).)))))......(((......(((((((..((...(((((((((.((.....((((((....))))))......)).).....(((....)))....((((((..((....))))))))))))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(..((((((((((.......)))))).))))...)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((((((...)))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((...(..((((....))))..)...((....))...)))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.((((((....((..(((.....))))).....))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((.((((((((....((((((.((((..((....)).))))))))))...)))))))).)))..))).))))..).))...)..)..(((((((((....)))))))))}.... A. baumannii ribosome-Streptothricin-F complex: 70S with P-site tRNA; 16s Ribosomal RNA 7uvv v 77 2.5 RF00005 URS00002D670D_480119 37192172 0030533 0006412 480119 ggcuaugnagcucaguuggnuagagcaccgcacucauaaugcgggggucacaagnucaagucucgucauagccacca <<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<.<<.......>>.>>>>>>>>>.... (((((((..((((.........)))).(((((.......))))).....((.((.......)).))))))))).... A. baumannii ribosome-Streptothricin-F complex: 70S with P-site tRNA; tRNA-met 7uvw A 2719 2.37 RF02541 URS000231197A_480119 37192172 0003735 0005840 480119 gucaaguaauuaagugcaugugguggaugccuuggcagucagaggcgaugaaagacgugauagccugcgaaaagcuccggggaggcggcaaauauccuuugauccggagaugucugaaugggggaacccaccuacuuuaagguagguauugcaacaugaauacauaguguugcaaggcgaacgaggggaagugaaacaucucaguacccuuaggaaaagaaaucaauugagauucccucaguagcggcgagcgaacggggaucagcccauuaaguuauguguguuuuaguggaacgcucugggaagugcgaacguagagggugauauucccguacacgaaagggcacacauaaugaugacgaguagggcgaggcacgugaaaccuugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccugugaggggagugaaauagauccugaaaccgcaugcauacaagcagugggagcaccuucguggugugacugcguaccuuuuguauaaugggucagcgacuuauauucaguagcgagguuaaccguauaggggagccguagagaaaucgagucuuaauagggcguuuaguugcuggguauagacccgaaaccaggcgaucuauccaugagcagguugaagguuggguaacacuaacuggaggaccgaacccacugucguugaaaagccaggggaugacuuguggauaggggugaaaggcuaaucaagccuggugauagcugguucuccccgaaagcuauuuagguagcgccucggacgaauaccauaggggguagagcacuguuucggcaccgaugcaaacuccgaauaccuaugaguacuauccgggagacagacugcgggugcuaacguccguagucaagaggaaaacaauccagaccgccagcuaaggccccaaaaucauaguuaagugggaaacgaugugggaaggcauagacagcuauagucgagucggccugcgcggaagauguaacggggcuaaaacuaugugccgaagcugcggauguauacuuuguauacgugguaggggagcguucuguaagccgaugaagguguguugagaagcaugcuggagguaucagaagugcgaaugcugacgugaguaacgacaaaacgggugaaaaacccguucgccgaaagaccaaggguuccaguccaacguuaaucggggcugggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaaaugguuaauauuccauuacuucuguguaaugcgaugagaggacggagaaggcuaaaucagccuggcguugguuguccaggugaaaggauguaggcauguaucuuaggcaaauccgggguacucuaugcugagaucugauagcaagcuguacuugugcagcgaagugguugaugccaugcuuccaggaaaagucucuaagcuucaguuacacaggaaucguacccgaaaccgacacagguggucaggucgaguagaccaaggcgcuugagagaacucugcugaaggaacuaggcaaaaugguaccguaacuucgggagaagguacgcuguuguuggugauggaacucgcuuccugagcugacgacagccgcagaaaccaggccgcugcaacuguuuauuaaaaacauagcacucugcaaacacgaaaguggacguauagggugugaugccugcccggugcuggaagguuaauugaugggguuagcguaagcgaagcucuugaucgaagccccaguaaacggcggccgguccuaagguagcgaaanuccuugucggguaaguuccgaccugcacgaauggcauaaugauggcggcgcugucuccagcagaggcucagugaaaucgaaaucgcugugnagaugcaguguacccgcggcuagacggaaagaccccgunaaccuuuacugcagcuugacacugaacuuugauugagguucuaacucugucccgugauccgggacgaggaccgugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggaguacgaaggugcgcucagcguggucggaaaucacgcguagaguauaaaggcaaaagcgcgcuuaacugcgagacccacaagucgagcagguacgaaaguaggucuuagugauccggugguucuguauggaagggccaucgcucaacggauaaaagguacucugnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgnugucggcucaucucauccuggggcugaagcaggucccaaggguauggcnguucgccauuuaaagagguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucuaccgugggcgcuggaaauuugagaggaucugcuccuaguacgagaggaccagaguggacgaaccucugguguaccgguugugacgccagucgcaucgccggguagcuauguucggaagggauaaccgcugaaagcaucuaagcgggaagccuaccucaagauaagauuucccuaggacuuuauguccucuaaagagccguucgagacuaggacguugauagguuggauguggaagcauagugauaugugaagcugaccaauacuaauugcucgugaggcuugacu <<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<.)))......>>.....>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<<..>>>...<<<<<.....<<.....>>....>>>>>...<<<......<<<<<<<<<<<<<..<<<...<<<.<......>.>>>((......<<<.....))>>>...>>>....>>>>>>>>>>>>>...........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..>>>......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<.....>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<.<........>.>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<....<<<<<<<<<.....<<<...<<<.<<<<..>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<..>>>....>>..>>>>>.>>...........)))......>>>>>>.>>>...>>>>>>><<<<<<<.....>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<...((((...>>>>>>....<<<<...<<<<.<<<<<<..<<.....>>.>>>>>>....>>>>...>>>>........<<<<<......>>>>>....>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<...<<<<.....>>>>...>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.......<<<<<..<<....>>...>>>>>.......>>>>>>>>>..>>>>><<<..>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<.<<<<.[[......<<<<.[[<<<<..<<<<..<<<.<<<<<.<<<<<<<<..>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>...>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<.................>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))))>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<<<<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>...>>>>..>..>>>>>>>. ((((((([.....((((((((((.....(((..(((((((((((((......((((((....[[[.))).....((((((...((.]]]......))......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.....((.(((((((((((.(((...(((.(......).)))[[(...).(((.....]])))...)))...))))))))))).))......)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((.....)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((.(.......<).))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).(((((((...((((((((((.....(((...(((.((((..)))).)))..)).).....)))))).))).).)))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{..((()))....)))..))))).))...........]]].)....))))))))))...)))))))((((((((...))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))....((((...((....((((((.((.....)))))))).......))..[)))).....(..((((.(....).))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((...(((((..)]))))...))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((())))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..(((((((..(((.((......(((..((((((..(((((.(((.(((((.((((.(((()))).))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..)).)))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(.(((((....))).)).)..>.))..))).)))))))[...(((((((...((((..((((((......(....).....)))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..)])))))(....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))..).)))))))). A. baumannii ribosome: 70S with E-site tRNA; 23s ribosomal RNA 7uvw B 115 2.37 RF00001 URS00002D8B10_480119 37192172 0003735 0005840 480119 gcuggcgaccauagcaagagugaaccaccugaucccuucccgaacucagaagugaaaccucuuagcgcugaugguagugugggauuacccaugugagaguaagucaucgccagcu <<<<<<<<.....<<<<<<<.....<<<<<<...............>>>..>>>....>>>>>.>><<<.......<<<<<<<....>>>>>>>.......>>>..>>>>>>>>. ((((((((.....(((((((.....(((((((...(.....)...))))..)))....))))).))(((.......(((((((....))))))).......)))..)))))))). A. baumannii ribosome: 70S with E-site tRNA; 5s ribosomal RNA 7uvw a 1528 2.37 RF00177,RF01959,RF02542,RF01960 URS00023119FB_480119 37192172 0003735 0005840 480119 uaacugaagaguuugaucauggcucagauugaacgcuggcggcaggcuuaacacaugcaagucgagcgggggaagguagcuugcuaccggaccuagcggcggacgggugaguaaugcuuaggaaucugccuauuagugggggacaacaucucgaaagggaugcuaauaccgcauacguccuacgggagaaagcaggggaucuucggaccuugcgcuaauagaugagccuaagucggauuagcuaguuggugggguaaaggccuaccaaggcgacgaucuguagcgggucugagaggaugauccgccacacugggacugagacacggcccagacuccuacgggaggcagcaguggggaauauuggacaauggggggaacccugauccagccaugccgcgugugugaagaaggccuuaugguuguaaagcacuuuaagcgaggaggaggcuacucuaguuaauaccuagggauaguggacguuacucgcagaauaagcaccggcuaacucugugccagcagccncgguaauacagagggugcgagcguuaaucggauuuacugggcguaaagcgugcguaggcggcuuauuaagucggaugugaaauccccgagcuuaacuugggaauugcauucgauacuggugagcuagaguaugggagaggaugguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgauggcgaaggcagccaucuggccuaauacugacgcugagguacgaaagcauggggagcaaacaggauuagauacccugguaguccaugccguaaacgaugucuacuagccguuggggccuuugaggcuuuaguggcgcagcuaacgcgauaaguagaccgccuggggaguacggucgcaagacuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggccuugacauacuagaaacuuuucagagauggauuggugccuucgggaaccuagauacaggugcugcauggcugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuuuuccuuacuugccagcauuucggaugggaacuuuaaggauacugccagugacaaacuggaggaaggcggggacgacgucaagucaucaugncccuuacggccagggcuacacacgugcuacaauggucgguacaaaggguugcuacacagcgaugugaugcuaaucucaaaaagccgaucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucgcggaucagaaugccgcggugaauacguucccgggccuuguacacaccgnccgucacaccaugggaguuuguugcaccagaaguagcuagccuaacugcaaagagggcgguuaccacgguguggccgaugacuggggugaagucgnaacaagguagccguaggggnnccugcggcuggauc ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<<...<<<<<....>>>>>...>>>.>>>>>......<<.......<<<<<<<..<<...<<<<<<<<<.<<.....<<<<<<....>>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>>>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<<<<<<<<<<.<...>.>>>>>>.>>>>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<<...>>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<...<..<<<<....>>>>..>...<<....>>...>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<<..<<<.....>>>>>.....>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<.<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>.>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((...((((((..))))))...))).)))))......(((......(((((((..((...(((((((((.((.....((((((....))))))......)).).....(((....)))....((((((..((....))))))))))))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(..((((((((((.......)))))).))))...)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((((((...)))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((...(..(.((....)).)..)...((....))...)))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.((((((....((..(((.....))))).....))))))..(..((((.......)))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((.((((((((....((((((.((((..((....)).))))))))))...)))))))).)))..))).))))..).))...)..)..(((((((((....)))))))))}.... A. baumannii ribosome: 70S with E-site tRNA; 16s Ribosomal RNA 7uvw v 77 2.37 RF00005 URS00002D670D_480119 37192172 0030533 0006412 480119 ggcuaugnagcucaguuggnuagagcaccgcacucauaaugcgggggucacaagnucaagucucgucauagccacca <<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<.<<.......>>.>>>>>>>>>.... (((((((..((((.........)))).(((((.......))))).....((.((.......)).))))))))).... A. baumannii ribosome: 70S with E-site tRNA; tRNA-met 7uvx A 2715 2.35 RF02541 URS000231197A_480119 37192172 0003735 0005840 480119 gucaaguaauuaagugcaugugguggaugccuuggcagucagaggcgaugaaagacgugauagccugcgaaaagcuccggggaggcggcaaauauccuuugauccggagaugucugaaugggggaacccaccuacuuuaagguagguauugcaacaugaauacauaguguugcaaggcgaacgaggggaagugaaacaucucaguacccuuaggaaaagaaaucaauugagauucccucaguagcggcgagcgaacggggaucagcccauuaaguuauguguguuuuaguggaacgcucugggaagugcgaacguagagggugauauucccguacacgaaagggcacacauaaugaugacgaguagggcgaggcacgugaaaccuugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccugugaggggagugaaauagauccugaaaccgcaugcauacaagcagugggagcaccuucguggugugacugcguaccuuuuguauaaugggucagcgacuuauauucaguagcgagguuaaccguauaggggagccguagagaaaucgagucuuaauagggcguuuaguugcuggguauagacccgaaaccaggcgaucuauccaugagcagguugaagguuggguaacacuaacuggaggaccgaacccacugucguugaaaagccaggggaugacuuguggauaggggugaaaggcuaaucaagccuggugauagcugguucuccccgaaagcuauuuagguagcgccucggacgaauaccauaggggguagagcacuguuucggcaccgaugcaaacuccgaauaccuaugaguacuauccgggagacagacugcgggugcuaacguccguagucaagaggaaaacaauccagaccgccagcuaaggccccaaaaucauaguuaagugggaaacgaugugggaaggcauagacagcuauagucgagucggccugcgcggaagauguaacggggcuaaaacuaugugccgaagcugcggauguauacuuuguauacgugguaggggagcguucuguaagccgaugaagguguguugagaagcaugcuggagguaucagaagugcgaaugcugacgugaguaacgacaaaacgggugaaaaacccguucgccgaaagaccaaggguuccaguccaacguuaaucggggcugggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaaaugguuaauauuccauuacuucuguguaaugcgaugagaggacggagaaggcuaaaucagccuggcguugguuguccaggugaaaggauguaggcauguaucuuaggcaaauccgggguacucuaugcugagaucugauagcaagcuguacuugugcagcgaagugguugaugccaugcuuccaggaaaagucucuaagcuucaguuacacaggaaucguacccgaaaccgacacagguggucaggucgaguagaccaaggcgcuugagagaacucugcugaaggaacuaggcaaaaugguaccguaacuucgggagaagguacgcuguuguuggugauggaacucgcuuccugagcugacgacagccgcagaaaccaggccgcugcaacuguuuauuaaaaacauagcacucugcaaacacgaaaguggacguauagggugugaugccugcccggugcuggaagguuaauugaugggguuagcguaagcgaagcucuugaucgaagccccaguaaacggcggccgguccuaagguagcgaaanuccuugucggguaaguuccgaccugcacgaauggcauaaugauggcggcgcugucuccagcagaggcucagugaaaucgaaaucgcugugnagaugcaguguacccgcggcuagacggaaagaccccgunaaccuuuacugcagcuugacacugaacuuugagguucuaacucugucccgugauccgggacgaggaccgugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggaguacgaaggugcgcucagcguggucggaaaucacgcguagaguauaaaggcaaaagcgcgcuuaacugcgagacccacaagucgagcagguacgaaaguaggucuuagugauccggugguucuguauggaagggccaucgcucaacggauaaaagguacucugnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgnugucggcucaucucauccuggggcugaagcaggucccaaggguauggcnguucgccauuuaaagagguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucuaccgugggcgcuggaaauuugagaggaucugcuccuaguacgagaggaccagaguggacgaaccucugguguaccgguugugacgccagucgcaucgccggguagcuauguucggaagggauaaccgcugaaagcaucuaagcgggaagccuaccucaagauaagauuucccuaggacuuuauguccucuaaagagccguucgagacuaggacguugauagguuggauguggaagcauagugauaugugaagcugaccaauacuaauugcucgugaggcuugacu 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((((((([.....((((((((((.....(((..(((((((((((((......((((((....[[[.))).....((((((...((.]]]......))......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.....((.(((((((((((.(((...(((.(......).)))[[(...).(((.....]])))...)))...))))))))))).))......)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((.....)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((.(.......<).))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).(((((((...((((((((((.....(((...(((.((((..)))).)))..)).).....)))))).))).).)))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{..((()))....)))..))))).))...........]]].)....))))))))))...)))))))((((((((...))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))....((((...((((.(((((((.((.....)))))))))....))))..[))))........((((((....))))))....)))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((...(((((..)]))))...))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((())))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..(((((((..(((.((......(((..((((((..(((((.(((.(((((.((((.(()).))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..)).)))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(.(((((....))).)).)..>.))..))).)))))))[...(((((((...((((..((((((......(....).....)))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..)])))))(....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))..).)))))))). A. baumannii 70S ribosome-Streptothricin-F complex; 23s ribosomal RNA 7uvx B 115 2.35 RF00001 URS00002D8B10_480119 37192172 0003735 0005840 480119 gcuggcgaccauagcaagagugaaccaccugaucccuucccgaacucagaagugaaaccucuuagcgcugaugguagugugggauuacccaugugagaguaagucaucgccagcu <<<<<<<<.....<<<<<<<.....<<<<<<...............>>>..>>>....>>>>>.>><<<.......<<<<<<<....>>>>>>>.......>>>..>>>>>>>>. ((((((((.....(((((((.....(((((((...(.....)...))))..)))....))))).))(((.......(((((((....))))))).......)))..)))))))). A. baumannii 70S ribosome-Streptothricin-F complex; 5s ribosomal RNA 7uvx a 1528 2.35 RF00177,RF01959,RF02542,RF01960 URS00023119FB_480119 37192172 0003735 0005840 480119 uaacugaagaguuugaucauggcucagauugaacgcuggcggcaggcuuaacacaugcaagucgagcgggggaagguagcuugcuaccggaccuagcggcggacgggugaguaaugcuuaggaaucugccuauuagugggggacaacaucucgaaagggaugcuaauaccgcauacguccuacgggagaaagcaggggaucuucggaccuugcgcuaauagaugagccuaagucggauuagcuaguuggugggguaaaggccuaccaaggcgacgaucuguagcgggucugagaggaugauccgccacacugggacugagacacggcccagacuccuacgggaggcagcaguggggaauauuggacaauggggggaacccugauccagccaugccgcgugugugaagaaggccuuaugguuguaaagcacuuuaagcgaggaggaggcuacucuaguuaauaccuagggauaguggacguuacucgcagaauaagcaccggcuaacucugugccagcagccncgguaauacagagggugcgagcguuaaucggauuuacugggcguaaagcgugcguaggcggcuuauuaagucggaugugaaauccccgagcuuaacuugggaauugcauucgauacuggugagcuagaguaugggagaggaugguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgauggcgaaggcagccaucuggccuaauacugacgcugagguacgaaagcauggggagcaaacaggauuagauacccugguaguccaugccguaaacgaugucuacuagccguuggggccuuugaggcuuuaguggcgcagcuaacgcgauaaguagaccgccuggggaguacggucgcaagacuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggccuugacauacuagaaacuuuucagagauggauuggugccuucgggaaccuagauacaggugcugcauggcugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuuuuccuuacuugccagcauuucggaugggaacuuuaaggauacugccagugacaaacuggaggaaggcggggacgacgucaagucaucaugncccuuacggccagggcuacacacgugcuacaauggucgguacaaaggguugcuacacagcgaugugaugcuaaucucaaaaagccgaucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucgcggaucagaaugccgcggugaauacguucccgggccuuguacacaccgnccgucacaccaugggaguuuguugcaccagaaguagcuagccuaacugcaaagagggcgguuaccacgguguggccgaugacuggggugaagucgnaacaagguagccguaggggnnccugcggcuggauc ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<<...<<<<<<..>>>>>>...>>>.>>>>>......<<.......<<<<<<<..<<...<<<<<<<<<.<<.....<<<<<<....>>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>>>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<<<<<<<<<<.<...>.>>>>>>.>>>>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<<...>>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<...<..<<<<....>>>>..>...<<....>>...>>>>.>>.<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<<..<<<.....>>>>>.....>>>>>>.....<<<<<.....>>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<.<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>.>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((...((((((..))))))...))).)))))......(((......(((((((..((...(((((((((.((.....((((((....))))))......)).).....(((....)))....((((((..((....))))))))))))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(..((((((((((.......)))))).))))...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((((((...)))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((...(..(.((....)).)..)...((....))...)))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.((((((....((..(((.....))))).....))))))..(..((((.......)))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((.((((((((....((((((.((((..((....)).))))))))))...)))))))).)))..))).))))..).))...)..)..(((((((((....)))))))))}.... A. baumannii 70S ribosome-Streptothricin-F complex; 16s Ribosomal RNA 7uvy A 2724 2.39 RF02541 URS000231197A_480119 37192172 0003735 0005840 480119 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((((((([.....((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...((.]]]...]..))......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.....((.(((((((((((.(((...(((.(......).)))[[(...).(((.....]])))...)))...))))))))))).))......)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((.....)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((.(.......<).))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).(((((((...((((((((((.....(((...(((.((((..)))).)))..)).).....)))))).))).).)))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{...(()).....)))..))))).))...........]]].)....))))))))))...)))))))((((((((...))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))....((((...((((.(((((((.((.....)))))))))....))))..[))))........((((((....))))))....)))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((...(((((..)]))))...))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..(((((((..(((.((......(((..((((((..(((((.(((.(((((.(((((())))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..)).)))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(.(((((....))).)).)..>.))..))).)))))))[...(((((((...((((..((((((......(....).....)))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..)])))))(....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))..).)))))))). A. baumannii ribosome-Streptothricin-D complex: 70S with P-site tRNA; 23s ribosomal RNA 7uvy B 115 2.39 RF00001 URS00002D8B10_480119 37192172 0003735 0005840 480119 gcuggcgaccauagcaagagugaaccaccugaucccuucccgaacucagaagugaaaccucuuagcgcugaugguagugugggauuacccaugugagaguaagucaucgccagcu <<<<<<<<.....<<<<<<<.....<<<<<<...............>>>..>>>....>>>>>.>><<<.......<<<<<<<....>>>>>>>.......>>>..>>>>>>>>. ((((((((.....(((((((.....(((((((...(.....)...))))..)))....))))).))(((.......(((((((....))))))).......)))..)))))))). A. baumannii ribosome-Streptothricin-D complex: 70S with P-site tRNA; 5s ribosomal RNA 7uvy a 1528 2.39 RF00177,RF01959,RF02542,RF01960 URS00023119FB_480119 37192172 0003735 0005840 480119 uaacugaagaguuugaucauggcucagauugaacgcuggcggcaggcuuaacacaugcaagucgagcgggggaagguagcuugcuaccggaccuagcggcggacgggugaguaaugcuuaggaaucugccuauuagugggggacaacaucucgaaagggaugcuaauaccgcauacguccuacgggagaaagcaggggaucuucggaccuugcgcuaauagaugagccuaagucggauuagcuaguuggugggguaaaggccuaccaaggcgacgaucuguagcgggucugagaggaugauccgccacacugggacugagacacggcccagacuccuacgggaggcagcaguggggaauauuggacaauggggggaacccugauccagccaugccgcgugugugaagaaggccuuaugguuguaaagcacuuuaagcgaggaggaggcuacucuaguuaauaccuagggauaguggacguuacucgcagaauaagcaccggcuaacucugugccagcagccncgguaauacagagggugcgagcguuaaucggauuuacugggcguaaagcgugcguaggcggcuuauuaagucggaugugaaauccccgagcuuaacuugggaauugcauucgauacuggugagcuagaguaugggagaggaugguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgauggcgaaggcagccaucuggccuaauacugacgcugagguacgaaagcauggggagcaaacaggauuagauacccugguaguccaugccguaaacgaugucuacuagccguuggggccuuugaggcuuuaguggcgcagcuaacgcgauaaguagaccgccuggggaguacggucgcaagacuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggccuugacauacuagaaacuuuucagagauggauuggugccuucgggaaccuagauacaggugcugcauggcugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuuuuccuuacuugccagcauuucggaugggaacuuuaaggauacugccagugacaaacuggaggaaggcggggacgacgucaagucaucaugncccuuacggccagggcuacacacgugcuacaauggucgguacaaaggguugcuacacagcgaugugaugcuaaucucaaaaagccgaucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucgcggaucagaaugccgcggugaauacguucccgggccuuguacacaccgnccgucacaccaugggaguuuguugcaccagaaguagcuagccuaacugcaaagagggcgguuaccacgguguggccgaugacuggggugaagucgnaacaagguagccguaggggnnccugcggcuggauc ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<<...<<<<<....>>>>>...>>>.>>>>>......<<.......<<<<<<<..<<...<<<<<<<<<.<<.....<<<<<<....>>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>>>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<<<<<<<<<<.<...>.>>>>>>.>>>>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<<...>>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<...<..<<<<....>>>>..>...<<....>>...>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<<..<<<.....>>>>>.....>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<.<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>.>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((...((((((..))))))...))).)))))......(((......(((((((..((...(((((((((.((.....((((((....))))))......)).).....(((....)))....((((((..((....))))))))))))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(..(((((.((((.......)))).).))))...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((((((...)))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((...(..(.((....)).)..)...((....))...)))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.((((((....((..(((.....))))).....))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((.((((((((....((((((.((((..((....)).))))))))))...)))))))).)))..))).))))..).))...)..)..(((((((((....)))))))))}.... A. baumannii ribosome-Streptothricin-D complex: 70S with P-site tRNA; 16s Ribosomal RNA 7uvy v 77 2.39 RF00005 URS00002D670D_480119 37192172 0030533 0006412 480119 ggcuaugnagcucaguuggnuagagcaccgcacucauaaugcgggggucacaagnucaagucucgucauagccacca <<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<.<<.......>>.>>>>>>>>>.... (((((((..((((.........)))).(((((.......))))).....((.((.......)).))))))))).... A. baumannii ribosome-Streptothricin-D complex: 70S with P-site tRNA; tRNA-met 7uvz A 2730 2.21 RF02541 URS000231197A_480119 37192172 0003735 0005840 480119 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((((((([.....((((((((((.....(((..(((((((((((((......((((((....[[[.))).....((((((...((.]]]......))......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((..(..((.(((((((((((.(((...(((.(......).)))[[(...).(((.....]])))...)))...))))))))))).))...)..)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((.....)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((.(.......<).))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).(((((((...((((((((((.....(((...(((.((((..)))).)))..)).).....)))))).))).).)))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{...(()).....)))..))))).))...........]]].)....))))))))))...)))))))((((((((...))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))....((((...((((.(((((((.((.....)))))))))....))))..[)))).....(..((((((....))))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((...((((....]))))...))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..(((((((..(((.((......(((..((((((..(((((.(((.(((((.((((.(((()))).))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..)).)))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(.(((((....))).)).)..>.))..))).)))))))[...(((((((...((((..((((((......(....).....)))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..)])))))(....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))..).)))))))). A. baumannii ribosome-Streptothricin-D complex: 70S with E-site tRNA; 23s ribosomal RNA 7uvz B 115 2.21 RF00001 URS00002D8B10_480119 37192172 0003735 0005840 480119 gcuggcgaccauagcaagagugaaccaccugaucccuucccgaacucagaagugaaaccucuuagcgcugaugguagugugggauuacccaugugagaguaagucaucgccagcu <<<<<<<<.....<<<<<<<.....<<<<<<...............>>>..>>>....>>>>>.>><<<.......<<<<<<<....>>>>>>>.......>>>..>>>>>>>>. ((((((((.....(((((((.....(((((((...(.....)...))))..)))....))))).))(((.......(((((((....))))))).......)))..)))))))). A. baumannii ribosome-Streptothricin-D complex: 70S with E-site tRNA; 5s ribosomal RNA 7uvz a 1528 2.21 RF00177,RF01959,RF02542,RF01960 URS00023119FB_480119 37192172 0003735 0005840 480119 uaacugaagaguuugaucauggcucagauugaacgcuggcggcaggcuuaacacaugcaagucgagcgggggaagguagcuugcuaccggaccuagcggcggacgggugaguaaugcuuaggaaucugccuauuagugggggacaacaucucgaaagggaugcuaauaccgcauacguccuacgggagaaagcaggggaucuucggaccuugcgcuaauagaugagccuaagucggauuagcuaguuggugggguaaaggccuaccaaggcgacgaucuguagcgggucugagaggaugauccgccacacugggacugagacacggcccagacuccuacgggaggcagcaguggggaauauuggacaauggggggaacccugauccagccaugccgcgugugugaagaaggccuuaugguuguaaagcacuuuaagcgaggaggaggcuacucuaguuaauaccuagggauaguggacguuacucgcagaauaagcaccggcuaacucugugccagcagccncgguaauacagagggugcgagcguuaaucggauuuacugggcguaaagcgugcguaggcggcuuauuaagucggaugugaaauccccgagcuuaacuugggaauugcauucgauacuggugagcuagaguaugggagaggaugguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgauggcgaaggcagccaucuggccuaauacugacgcugagguacgaaagcauggggagcaaacaggauuagauacccugguaguccaugccguaaacgaugucuacuagccguuggggccuuugaggcuuuaguggcgcagcuaacgcgauaaguagaccgccuggggaguacggucgcaagacuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggccuugacauacuagaaacuuuucagagauggauuggugccuucgggaaccuagauacaggugcugcauggcugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuuuuccuuacuugccagcauuucggaugggaacuuuaaggauacugccagugacaaacuggaggaaggcggggacgacgucaagucaucaugncccuuacggccagggcuacacacgugcuacaauggucgguacaaaggguugcuacacagcgaugugaugcuaaucucaaaaagccgaucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucgcggaucagaaugccgcggugaauacguucccgggccuuguacacaccgnccgucacaccaugggaguuuguugcaccagaaguagcuagccuaacugcaaagagggcgguuaccacgguguggccgaugacuggggugaagucgnaacaagguagccguaggggnnccugcggcuggauc ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<<...<<<<<....>>>>>...>>>.>>>>>......<<.......<<<<<<<..<<...<<<<<<<<<.<<.....<<<<<<....>>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>>>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<<<<<<<<<<.<...>.>>>>>>.>>>>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<<...>>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<...<..<<<<....>>>>..>...<<....>>...>>>>.>>.<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<<..<<<.....>>>>>.....>>>>>>.....<<<<<.....>>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<.<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>.>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((...((((((..))))))...))).)))))......(((......(((((((..((...(((((((((.((.....((((((....))))))......)).).....(((....)))....((((((..((....))))))))))))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(..((((((((((.......)))))).))))...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((((((...)))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((...(..(.((....)).)..)...((....))...)))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.((((((....((..(((.....))))).....))))))..(..((((.......)))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((.((((((((....((((((.((((..((....)).))))))))))...)))))))).)))..))).))))..).))...)..)..(((((((((....)))))))))}.... A. baumannii ribosome-Streptothricin-D complex: 70S with E-site tRNA; 16s Ribosomal RNA 7uvz v 77 2.21 RF00005 URS00002D670D_480119 37192172 0030533 0006412 480119 ggcuaugnagcucaguuggnuagagcaccgcacucauaaugcgggggucacaagnucaagucucgucauagccacca <<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<.<<.......>>.>>>>>>>>>.... (((((((..((((.........)))).(((((.......))))).....((.((.......)).))))))))).... A. baumannii ribosome-Streptothricin-D complex: 70S with E-site tRNA; tRNA-met 7uw1 A 2726 2.21 RF02541 URS000231197A_480119 37192172 0003735 0005840 480119 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A. baumannii 70S ribosome-Streptothricin-D complex; 23s ribosomal RNA 7uw1 B 115 2.21 RF00001 URS00002D8B10_480119 37192172 0003735 0005840 480119 gcuggcgaccauagcaagagugaaccaccugaucccuucccgaacucagaagugaaaccucuuagcgcugaugguagugugggauuacccaugugagaguaagucaucgccagcu <<<<<<<<.....<<<<<<<.....<<<<<<...............>>>..>>>....>>>>>.>><<<.......<<<<<<<....>>>>>>>.......>>>..>>>>>>>>. ((((((((.....(((((((.....(((((((...(.....)...))))..)))....))))).))(((.......(((((((....))))))).......)))..)))))))). A. baumannii 70S ribosome-Streptothricin-D complex; 5s ribosomal RNA 7uw1 a 1528 2.21 RF00177,RF01959,RF02542,RF01960 URS00023119FB_480119 37192172 0003735 0005840 480119 uaacugaagaguuugaucauggcucagauugaacgcuggcggcaggcuuaacacaugcaagucgagcgggggaagguagcuugcuaccggaccuagcggcggacgggugaguaaugcuuaggaaucugccuauuagugggggacaacaucucgaaagggaugcuaauaccgcauacguccuacgggagaaagcaggggaucuucggaccuugcgcuaauagaugagccuaagucggauuagcuaguuggugggguaaaggccuaccaaggcgacgaucuguagcgggucugagaggaugauccgccacacugggacugagacacggcccagacuccuacgggaggcagcaguggggaauauuggacaauggggggaacccugauccagccaugccgcgugugugaagaaggccuuaugguuguaaagcacuuuaagcgaggaggaggcuacucuaguuaauaccuagggauaguggacguuacucgcagaauaagcaccggcuaacucugugccagcagccncgguaauacagagggugcgagcguuaaucggauuuacugggcguaaagcgugcguaggcggcuuauuaagucggaugugaaauccccgagcuuaacuugggaauugcauucgauacuggugagcuagaguaugggagaggaugguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgauggcgaaggcagccaucuggccuaauacugacgcugagguacgaaagcauggggagcaaacaggauuagauacccugguaguccaugccguaaacgaugucuacuagccguuggggccuuugaggcuuuaguggcgcagcuaacgcgauaaguagaccgccuggggaguacggucgcaagacuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggccuugacauacuagaaacuuuucagagauggauuggugccuucgggaaccuagauacaggugcugcauggcugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuuuuccuuacuugccagcauuucggaugggaacuuuaaggauacugccagugacaaacuggaggaaggcggggacgacgucaagucaucaugncccuuacggccagggcuacacacgugcuacaauggucgguacaaaggguugcuacacagcgaugugaugcuaaucucaaaaagccgaucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucgcggaucagaaugccgcggugaauacguucccgggccuuguacacaccgnccgucacaccaugggaguuuguugcaccagaaguagcuagccuaacugcaaagagggcgguuaccacgguguggccgaugacuggggugaagucgnaacaagguagccguaggggnnccugcggcuggauc ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<<...<<<<<<..>>>>>>...>>>.>>>>>......<<.......<<<<<<<..<<...<<<<<<<<<.<<.....<<<<<<....>>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>>>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<<<<<<<<<<.<...>.>>>>>>.>>>>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<<...>>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<...<..<<<<....>>>>..>...<<....>>...>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<<..<<<.....>>>>>.....>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<.<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>.>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((...((((((..))))))...))).)))))......(((......(((((((..((...(((((((((.((.....((((((....))))))......)).).....(((....)))....((((((..((....))))))))))))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(..((((((((((.......)))))).))))...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((((((...)))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((...(..(.((....)).)..)...((....))...)))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.((((((....((..(((.....))))).....))))))..(..((((.......)))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((.((((((((....((((((.((((..((....)).))))))))))...)))))))).)))..))).))))..).))...)..)..(((((((((....)))))))))}.... A. baumannii 70S ribosome-Streptothricin-D complex; 16s Ribosomal RNA 7uzx G 31 3.49 URS00023359D7_176279 35714601 176279 acgagaacuaguaauaauugucauuugcaua ............................... ............................... Staphylococcus epidermidis RP62a CRISPR effector subcomplex with non-self target RNA bound; Staphylococcus epidermidis RP62A CRISPR RNA: Repeat plus Spacer sequence 2 7uzy G 30 4.05 URS00023359D7_176279 35714601 176279 acgagaacuaguaauaauugucauuugcau .............................. .............................. Staphylococcus epidermidis RP62A CRISPR effector complex with non-self target RNA 2; RNA (37-MER) 7uzy L 14 4.05 URS00023359D8_176279 35714601 176279 augcaaaugaaauu .............. .............. Staphylococcus epidermidis RP62A CRISPR effector complex with non-self target RNA 2; RNA (40-MER) 7v01 G 30 3.67 URS00023359D5_176279 35714601 176279 acgagaacacguaugccgaaguauauaaau .............................. .............................. Staphylococcus epidermidis RP62a CRISPR short effector complex with self RNA target and ATP; RNA (37-MER) 7v01 U 25 3.67 URS00023359D4_176279 35714601 176279 auuuauauacuucggcuacguguuc ......................... ......................... Staphylococcus epidermidis RP62a CRISPR short effector complex with self RNA target and ATP; RNA (37-MER) 7v08 1 2986 2.36 RF02543 URS000061F377_1247190 36864048 0003735 0005840 1247190 guuugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacnnggaccaaggagunuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccnanagauggugancuaugccugaauagggugaagccagaggaaacucugguggaggcucguancgguucugncgugcaaaucgaucgucgaaunuggguauagnggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugaguguaagaaguccuuguuugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcngaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaunuuggugguagunncaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaanguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauunaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugccnagugcucugaaugucaaagugangaaauucaaccaagcgcggguaaacggcgggaguacucucuuaagguagcnaauggauuaacgagauucccacugunccuaucuacnaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcungacncuaguuugacauugugaagagacauaguuucuuuacuuauucaaugaagcggagcuggauccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauunucagngugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuanangugccagaaaaguuaccacagngauaacuggcuuguggcagucaagcguuauagcgacauugcuuuuugauungaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauacccacuaauagggaacggnuggguuuagancgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagcguuacgaucugcugagauuaagccuuuguugucugauuugu ..........................<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<.<<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>>..>>>>>>>....>>>>>>>>>>>........<<<<<<<.<....>.>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<......<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<......>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<...<<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<..............>>>>.>>.>>....>>>>>>.>>>>>>>.<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<......<<<....>>>..<<<<<<<<<<...<<<.<<<<<<<..>>>>>...<<<<.<<<....>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<......<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>....>>>>>>.>>>>..>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>...<...<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>...>......>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<.....<..>......>>>>><<.<<<<<<<<<<<..>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>.......<<<..<<<<<<.....<<....<<<<<....>>>>.>...>>..>>>>..>>>>><<<<<..>>>>>..........<<.>>......>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..[[[........(((((([[[.[[..<<<<<.<<<<<<<<..<<<<<<<<<.....>>>>>>>>>...<<<<<.....<<<<...<<..>>................<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>.......<<<<<<..<..>..>>..<<<<<<<...<<<<<<.......>>>>>>.....<<......>>....>>>>>>>....<<<<.<.<<<.....>>>.>>>>><<<<....>>>.>>>>>.[[...[[.((((..((((.>>>>>>)))))))).]].....]]..]]]]]..)))))).............<<<<<<...<<......>>...>>>>>>.............<<<<<..<<<<<..<.<<<<<<<......>>>>>>>...>.<<<....>>>.....>>>>>...>>>>>.....<<<<<<<....>>>.>>>>........]]].]]]]]....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>........<<<<<.<.<.......<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>...............>..>.>>>.>>..<<<<<<<.............>.....<<<<<<<<<.<<<....<<<<.<..<<<<..>>>>..>>>>>...>>>....>>>>.>>>>>.>>>>>>.. ..........................(((((......((....)).......)))).).........((....))...((((......((.....)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))))....)))))))))))...)....(((((((.(....).))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.(((((......(((((((((((((((((((((((.......(((((((......(((..........))).......))))))).....))))).))))))))))........(((....)))....)))))))).....))))).))))).<((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))..).))))))))).(.((.....B.))...)..))))))......).))..((((((......((([...)))..(((.((((((...(((.(.(((.(..).)))...((((..((....))..))))......)))).)))))).).))..((((.((.((.....)).)).))))....(((......)))...(((((((...((([[[...(.((((((......(....A.....(((.((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((....)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((..((((((....((.....))..)))))....[[(((.((...((....(((....)))........((((((........))))))....))....))...(((((........)))))]]((((..(((((((...((((....)))...(.[.((((((...((((.((((((((((((((((((..{{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((.(......).))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).))).))).....((......)).)))).((((.....))))..))))..(.(......((((((..((..(....(.......(((((....(.[..).....)))))((.(((((((((((..)))))..)))))).))(...).......(((((((.(.>.((.........))...(((((((....((((.....))))......))))))).].....(((..((((.(.....(......((((....))))......)..).))..)))))(.(.(()).).)..........(...)......)..))))))).)..)))..))))))...).)))....)).[..(((((.....>].)))))....(((((..(((.(......(((((((((.(...(((((.((((((((..(((((((.(.....).)))))))....((((.....((((..(((())))...........]...((((((....))))))..))))..))))......))))))))..)))))...]...((((.(...()...)...(((((((.(.((((((.......))))))...).((......))....)))))))....((((.(.(((.....))).)))))((((....))).))))).((....(..(((..((((.]]]]]])))))))..)......))...))))b.)))))).......a[....((((((...((......))...))))))..............((((..(((((..(.(((((((......))))))..).).(((.().))).....)))))..])))).......((((((....))).)))...a..)..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}}.)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......(.((((.((........((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).))))))................).).))).))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(((.().)))..)))))...)))....)))).)))))).))))).. Nucleoplasmic pre-60S intermediate of the Nog2 containing pre-rotation state from a Spb1 D52A suppressor 3 strain; 25S rRNA 7v08 2 158 2.36 RF00002 URS00001BF64E_1247190 36864048 0003735 0005840 1247190 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Nucleoplasmic pre-60S intermediate of the Nog2 containing pre-rotation state from a Spb1 D52A suppressor 3 strain; 5.8S rRNA 7v08 6 58 2.36 URS000268138E_1247190 36864048 1247190 ccuucucaaacauguuugguagugagugauacucgaguuaacuugaaauugccuuaaa ......<<<<<..>>>>>.....<<<<.<.<<<..>>>>.>>>>.............. .......((((())))).....(((((...(((..)))..))))..)........... Nucleoplasmic pre-60S intermediate of the Nog2 containing pre-rotation state from a Spb1 D52A suppressor 3 strain; ITS2 7v6c C 21 3.3 URS00023358F6_7227 35768503 7227 augagguaguagguuguauag ..................... ..................... Structure of the Dicer-2-R2D2 heterodimer bound to small RNA duplex; RNA (5'-R(*AP*UP*GP*AP*GP*GP*UP*AP*GP*UP*AP*GP*GP*UP*UP*GP*UP*AP*UP*AP*G)-3') 7v6c D 21 3.3 URS00023358C1_7227 35768503 7227 cuauacaaccuacuaccucuc ..................... ..................... Structure of the Dicer-2-R2D2 heterodimer bound to small RNA duplex; RNA (5'-R(*CP*UP*AP*UP*AP*CP*AP*AP*CP*CP*UP*AP*CP*UP*AP*CP*CP*UP*CP*UP*C)-3') 7v9u E 57 3.12 URS0002616B7B_562 35982312 562 ccuuagcgagagguccucuggauguuguuucggcauccugcauugaaucugaguuac ........<<<<<.>>>>><<<<<<<.....>>>>>>>................... .......((((((.)))))((((((((...))))))))..)................ Cryo-EM structure of E.coli retron-Ec86 (RT-msDNA-RNA) at 3.2 angstrom; RNA (81-MER) 7v9u G 58 3.12 URS0002616B7B_562 35982312 562 cccuuagcgagagguccucuggauguuguuucggcauccugcauugaaucugaguuac .........<<<<<.>>>>><<<<<<<.....>>>>>>>................... ........((((((.)))))((((((((...))))))))..)................ Cryo-EM structure of E.coli retron-Ec86 (RT-msDNA-RNA) at 3.2 angstrom; RNA (81-MER) 7v9x E 58 2.82 URS0002616B7B_562 562 cccuuagcgagagguccucuggauguuguuucggcauccugcauugaaucugaguuac .........<<<<...>>>><<<<<<<.....>>>>>>>................... ........((((((.)))))((((((((...))))))))..)................ Cryo-EM structure of E.coli retron-Ec86 in complex with its effector at 2.8 angstrom; RNA (81-MER) 7v9x H 58 2.82 URS0002616B7B_562 562 cccuuagcgagagguccucuggauguuguuucggcauccugcauugaaucugaguuac .........<<<<<.>>>>><<<<<<<.....>>>>>>>................... ........((((((.)))))((((((((...))))))))..)................ Cryo-EM structure of E.coli retron-Ec86 in complex with its effector at 2.8 angstrom; RNA (81-MER) 7vft A 23 1.45 URS00023359C2_9606 35776134 9606 gggccagcagcagcagcaggucc ....................... ....................... Crystal structure of rGGGC(CAG)5GUCC oligo; RNA (5'-R(*GP*GP*GP*CP*CP*AP*GP*CP*AP*GP*CP*AP*GP*CP*AP*GP*CP*AP*GP*GP*UP*CP*C)-3') 7vg2 C 35 3.1 URS00023119CD_3702 34648373 3702 aacaagcgaaugagucauucauccuaagucugcau ................................... ................................... Cryo-EM structure of Arabidopsis DCL3 in complex with a 40-bp RNA; TAS1a forward strand (5'-phosphorylation) 7vg2 D 36 3.1 URS0002311A22_3702 34648373 3702 augcagacuuaggaugaaugacucauucgcuuguuc .................................... .................................... Cryo-EM structure of Arabidopsis DCL3 in complex with a 40-bp RNA; TAS1a reverse strand 7vg3 C 30 3.73 URS00023119B3_3702 34648373 3702 uacaagcgaaugagucauucauccuaaguc .............................. .............................. Cryo-EM structure of Arabidopsis DCL3 in complex with a 30-bp RNA; TAS1a RNA forward strand (5'-phosphorylated) 7vg3 D 32 3.73 URS000231198A_3702 34648373 3702 gacuuaggaugaaugacucauucgcuuguaga ................................ ................................ Cryo-EM structure of Arabidopsis DCL3 in complex with a 30-bp RNA; TAS1a RNA reverse strand 7vpx H 130 3.0 RF00004 URS00003EE995_9606 38196034 0045131 0000348 0005686 9606 uaguaucuguucuuaucaguuuaauaucugauuccucgaggaggauuuuuggagcagggagauggaauaggagcuugcuccguccacuccacgcaucgaccugguauugcaguaccuccaggaacggugc ..............<<<<<.<....>.>>>>><<<<..>>>>...............<<<<.<<<<...<<<<....>>>>.>>>>>>>>..<<<<<<.<<<<<.............>>>>>..>>>>>> ..............(((((........)))))((((()))))...............(((..(((....((((....))))..))).)))..(((.((..((((.............))))...)).))) The cryo-EM structure of the human pre-A complex; U2 snRNA 7vpx I 15 3.0 38196034 10535 ugaagcuuucauacu ............... ............... The cryo-EM structure of the human pre-A complex; pre-mRNA 7vpx K 10 3.0 URS00026813F5_10535 38196034 10535 gggugaguac .......... .......... The cryo-EM structure of the human pre-A complex; 5SS 7vpx L 164 3.0 RF00003 URS000032B6B6_9606 38196034 0030627 0000395 0005685 9606 auacuuaccuggcaggggagauaccaugaucacgaaggugguuuucccagggcgaggcuuauccauugcacuccggaugugcugaccccugcgauuuccccaaaugugggaaacucgacugcauaauuugugguagugggggacugcguucgcgcuuuccccug ...........<<<<.<<<<<.<<<<<..........>>>>>>>>>>.<<<<...<<<.<<<<<..........>>>>>.>>>...>>>>.<<<<<<<<<.......>>>>>>.>>>.>>>>...............<<<<<<..<<<....>>>..>>>>>>. ............(((.(((((..((((..........)))).))))).((((...(((.(((((..........))))).)))...))))..(.((((((.......))))))..)..)))................((((((..(((....)))..)))))). The cryo-EM structure of the human pre-A complex; U1 snRNA 7vtn B 56 3.38 URS0002616B69_32630 36027912 32630 gcaaccauucaaauauguaugcuggagcagcccccgauuuguggggugauuacagc ....................<<<<<....<<<<<........>>>>>...>.>>>> ....................(((((...(((((((.....).)))))..)).)))) Cryo-EM structure of the Cas13bt3-crRNA-target RNA ternary complex; crRNA 7vtn C 20 3.38 URS0002616B71_32630 36027912 32630 auacauauuugaaugguugc .................... .................... Cryo-EM structure of the Cas13bt3-crRNA-target RNA ternary complex; target RNA 7w0a C 31 3.12 URS00023358C3_7227 35768513 7227 agagacuugggcaaugugacugcugaucagc ............................... ............................... dmDicer2-LoqsPD-dsRNA Dimer status; RNA (30-MER) 7w0a D 32 3.12 URS00023358D4_7108 35768513 7108 gcugaucagcagucacauugcccaagucucuu ................................ ................................ dmDicer2-LoqsPD-dsRNA Dimer status; RNA (32-MER) 7w0a G 31 3.12 URS00023358C3_7227 35768513 7227 agagacuugggcaaugugacugcugaucagc ............................... ............................... dmDicer2-LoqsPD-dsRNA Dimer status; RNA (30-MER) 7w0a H 32 3.12 URS00023358D4_7108 35768513 7108 gcugaucagcagucacauugcccaagucucuu ................................ ................................ dmDicer2-LoqsPD-dsRNA Dimer status; RNA (32-MER) 7w0c C 35 3.93 URS00023358B9_7227 35768513 7227 gagacuugggcaaugugacugcugaucagcaguca ................................... ................................... Dicer2-Loqs-PD-dsRNA complex at early-translocation state; RNA (35-MER) 7w0c D 37 3.93 URS00023358B9_7227 35768513 7227 ugacugcugaucagcagucacauugcccaagucucuu ..................................... ..................................... Dicer2-Loqs-PD-dsRNA complex at early-translocation state; RNA (35-MER) 7w0d D 52 4.18 URS00023358B9_7227 35768513 7227 gagacuugggcaaugugacugcugaucagcagucacauugcccaagucucuu .................................................... .................................................... Dicer2-LoqsPD-dsRNA complex at mid-translocation state; dsRNA 7w0d C 52 4.18 URS00023358B9_7227 35768513 7227 gagacuugggcaaugugacugcugaucagcagucacauugcccaagucucuu .................................................... .................................................... Dicer2-LoqsPD-dsRNA complex at mid-translocation state; dsRNA 7w0e C 53 4.03 URS00023358D3_7227 35768513 7227 agagacuugggcaaugugacugcugaucagcagucacauugcccaagucucuu ..................................................... ..................................................... dmDicer2-LoqsPD-dsRNA Active-dicing status; dsRNA 7w0e D 52 4.03 URS00023358D3_7227 35768513 7227 gagacuugggcaaugugacugcugaucagcagucacauugcccaagucucuu .................................................... .................................................... dmDicer2-LoqsPD-dsRNA Active-dicing status; dsRNA 7w0f C 21 4.55 URS00023358B9_7227 35768513 7227 gagacuugggcaaugugacug ..................... ..................... dmDicer2-LoqsPD-dsRNA Post-dicing status; siRNA 7w0f D 21 4.55 URS00023358B9_7227 35768513 7227 gucacauugcccaagucucuu ..................... ..................... dmDicer2-LoqsPD-dsRNA Post-dicing status; siRNA 7w0f E 26 4.55 URS00023358B9_7227 35768513 7227 cagcagucacauugcccaagucucuu .......................... .......................... dmDicer2-LoqsPD-dsRNA Post-dicing status; siRNA 7w0f F 26 4.55 URS00023358B9_7227 35768513 7227 gagacuugggcaaugugacugcugau .......................... .......................... dmDicer2-LoqsPD-dsRNA Post-dicing status; siRNA 7w59 4 13 3.6 35705093 10535 cggccuccgaacg ............. ............. The cryo-EM structure of human pre-C*-I complex; pre-mRNA 7w59 G 82 3.6 35705093 10535 guaagagccuagcauguagaacugguuaccuccaggguuuccuugaugaugucauacuuauccuguacagcucgcgguugag .................................................................................. .................................................................................. The cryo-EM structure of human pre-C*-I complex; pre-mRNA 7w59 B 84 3.6 RF00020 URS000075BAAE_9606 35705093 0000244,0000353 0005682,0046540 9606 gguuucucuucagaucgcauaaaucuuucgccuuuuacuaaagauuuccguggagaggaacaacccaauuuuuugaggccuugc .<<<<<<<<<<<........<<<<<<<<...........>>>>>>>>...>>>>>>>>>>>....................... .(((.(((((((....(...((((((((.(.......).)))))))).).))))))).)))....................... The cryo-EM structure of human pre-C*-I complex; U5 snRNA 7w59 F 97 3.6 RF00026 URS00001EC8D7_9606 35705093 0030621 0000244,0000353 0005688,0046540 9606 gugcucgcuucggcagcacauauacuaaaauuggaacgauacagagaagauuagcauggccccugcgcaaggaugacacgcaaauucgugaagcguu <<<<<.<<<..>>>>>>>>.....................................<<...<<<.....>>>....>>................... (((((.((....))))))).....................................((..((((.....)))..).))................... The cryo-EM structure of human pre-C*-I complex; U6 snRNA 7w59 H 140 3.6 RF00004 URS00003EE995_9606 35705093 0045131 0000348 0005686 9606 aucgcuucucggccuuuuggcuaagaucaaguguaguaucuguucuuuuaauaucguccucuaccgaggacaauauuaaggauuuuuggagcagggagccacgcaucgaccugguauugcaguaccuccaggaacggugc ...............................................<<<<<<<.<<<<<<....>>>>>>.>>>>>>>...............<......><<<<<<.<<<<<.............>>>>>..>>>>>> ...............................................(((((((.((((((....)))))).)))))))...............(..()..)(((.((.(((((.............)))))..)).))) The cryo-EM structure of human pre-C*-I complex; U2 snRNA 7w5a B 84 3.6 RF00020 URS000075BAAE_9606 35705093 0000244,0000353 0005682,0046540 9606 gguuucucuucagaucgcauaaaucuuucgccuuuuacuaaagauuuccguggagaggaacaacccaauuuuuugaggccuugc .<<<<<<<<<<<........<<<<<<<<...........>>>>>>>>...>>>>>>>>>>>....................... .(((.(((((((....(...((((((((.(.......).)))))))).).))))))).)))....................... The cryo-EM structure of human pre-C*-II complex; U5 snRNA 7w5a F 97 3.6 RF00026 URS00001EC8D7_9606 35705093 0030621 0000244,0000353 0005688,0046540 9606 gugcucgcuucggcagcacauauacuaaaauuggaacgauacagagaagauuagcauggccccugcgcaaggaugacacgcaaauucgugaagcguu <<<<<.<<<..>>>>>>>>.....................................<<...<<<.....>>>....>>................... (((((.((....))))))).....................................((..((((.....)))..).))................... The cryo-EM structure of human pre-C*-II complex; U6 snRNA 7w5a 4 13 3.6 35705093 10535 cggccuccgaacg ............. ............. The cryo-EM structure of human pre-C*-II complex; Pre-mRNA 7w5a G 82 3.6 35705093 10535 guaagagccuagcauguagaacugguuaccuccaggguuuccuugaugaugucauacuuauccuguacagcucgcgguugag .................................................................................. .................................................................................. The cryo-EM structure of human pre-C*-II complex; Pre-mRNA 7w5a H 140 3.6 RF00004 URS00003EE995_9606 35705093 0045131 0000348 0005686 9606 aucgcuucucggccuuuuggcuaagaucaaguguaguaucuguucuuuuaauaucguccucuaccgaggacaauauuaaggauuuuuggagcagggagccacgcaucgaccugguauugcaguaccuccaggaacggugc ...............................................<<<<<<..<<<<<<....>>>>>>..>>>>>>...............<......><<<<<<.<<<<<.............>>>>>..>>>>>> ...............................................(((((((.((((((....)))))).)))))))...............(..()..)(((.((.(((((.............)))))..)).))) The cryo-EM structure of human pre-C*-II complex; U2 snRNA 7w5b B 84 4.3 RF00020 URS000075BAAE_9606 35705093 0000244,0000353 0005682,0046540 9606 gguuucucuucagaucgcauaaaucuuucgccuuuuacuaaagauuuccguggagaggaacaacccaauuuuuugaggccuugc .<<<<<<<<<<<........<<<<<<<<...........>>>>>>>>...>>>>>>>>>>>....................... .(((.(((((((....(...((((((((.(.......).)))))))).).))))))).)))....................... The cryo-EM structure of human C* complex; U5 snRNA 7w5b F 97 4.3 RF00026 URS00001EC8D7_9606 35705093 0030621 0000244,0000353 0005688,0046540 9606 gugcucgcuucggcagcacauauacuaaaauuggaacgauacagagaagauuagcauggccccugcgcaaggaugacacgcaaauucgugaagcguu <<<<<.<<<..>>>>>>>>.....................................<<...<<<.....>>>....>>................... (((((.((....))))))).....................................((..((((.....)))..).))................... The cryo-EM structure of human C* complex; U6 snRNA 7w5b 4 13 4.3 35705093 10535 cggccuccgaacg ............. ............. The cryo-EM structure of human C* complex; Pre-mRNA 7w5b G 82 4.3 35705093 10535 guaagagccuagcauguagaacugguuaccuccaggguuuccuugaugaugucauacuuauccuguacagcucgcgguugag .................................................................................. .................................................................................. The cryo-EM structure of human C* complex; Pre-mRNA 7w5b H 140 4.3 RF00004 URS00003EE995_9606 35705093 0045131 0000348 0005686 9606 aucgcuucucggccuuuuggcuaagaucaaguguaguaucuguucuuuuaauaucguccucuaccgaggacaauauuaaggauuuuuggagcagggagccacgcaucgaccugguauugcaguaccuccaggaacggugc ...............................................<<<<<<..<<<<<<....>>>>>>..>>>>>>...............<......><<<<<<.<<<<<.............>>>>>..>>>>>> ...............................................(((((((.((((((....)))))).)))))))...............(..()..)(((.((.(((((.............)))))..)).))) The cryo-EM structure of human C* complex; U2 snRNA 7w9s B 12 2.53 URS000080DEB1_32630 36477355 32630 ggucucucucgu ............ ............ Crystal structure of the enterovirus 71 polymerase elongation complex (C1S3 form); RNA (35-MER) 7w9s C 10 2.53 URS000080DFD6_32630 36477355 32630 acgagagaga .......... .......... Crystal structure of the enterovirus 71 polymerase elongation complex (C1S3 form); RNA (5'-R(*UP*GP*UP*UP*CP*GP*AP*CP*GP*AP*GP*AP*GP*AP*GP*AP*CP*CP*U)-3') 7wah R 39 2.45 URS00023359C1_562 35643083 562 gugaugucacggaaccuuuguugucuucgacauggguaa ....................................... ....................................... Structure of Cas7-11 in complex with guide RNA and target RNA; crRNA (39-MER) 7wah D 23 2.45 URS00023359BE_562 35643083 562 uacccaugucgaagacaacaaag ....................... ....................... Structure of Cas7-11 in complex with guide RNA and target RNA; tgRNA (5'-R(P*UP*AP*CP*CP*CP*AP*UP*GP*UP*CP*GP*AP*AP*GP*AP*CP*AP*AP*CP*AP*AP*AP*G)-3') 7wm4 A 81 3.2 URS0002681371_32630 36631495 32630 aaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaauuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuu ................................................................................. ................................................................................. Cryo-EM structure of tetrameric TLR3 in complex with dsRNA (90 bp); RNA (81-MER) 7wm4 B 81 3.2 URS000268137B_32630 36631495 32630 aaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaauuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuu ................................................................................. ................................................................................. Cryo-EM structure of tetrameric TLR3 in complex with dsRNA (90 bp); RNA (81-MER) 7wv3 E 80 2.26 URS000261778B_32630 36371424 32630 cccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccc ................................................................................ ................................................................................ Toll-like receptor3 linear cluster; RNA (80-MER) 7wv3 F 80 2.26 URS000261776D_32630 36371424 32630 iiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiii ................................................................................ ................................................................................ Toll-like receptor3 linear cluster; RNA (80-MER) 7wv4 E 80 3.35 URS000261778B_32630 36371424 32630 cccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccccc ................................................................................ ................................................................................ ectoTLR3-poly(I:C) cluster; RNA (80-MER) 7wv4 F 80 3.35 URS000261776D_32630 36371424 32630 iiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiii ................................................................................ ................................................................................ ectoTLR3-poly(I:C) cluster; RNA (80-MER) 7wv5 E 46 3.1 URS000261776A_32630 36371424 32630 cccccccccccccccccccccccccccccccccccccccccccccc .............................................. .............................................. ectoTLR3-poly(I:C); RNA (46-MER) 7wv5 F 46 3.1 URS0002617765_32630 36371424 32630 iiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiii .............................................. .............................................. ectoTLR3-poly(I:C); RNA (46-MER) 7wve E 46 3.11 URS000261776A_32630 36371424 32630 cccccccccccccccccccccccccccccccccccccccccccccc .............................................. .............................................. CT-mut (D523K,D524K,E527K) TLR3-poly(I:C) complex; RNA (46-MER) 7wve F 46 3.11 URS0002617765_32630 36371424 32630 iiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiii .............................................. .............................................. CT-mut (D523K,D524K,E527K) TLR3-poly(I:C) complex; RNA (46-MER) 7wvf E 46 3.91 URS000261776A_32630 36371424 32630 cccccccccccccccccccccccccccccccccccccccccccccc .............................................. .............................................. ectoTLR3-mAb12-poly(I:C) complex; RNA (46-MER) 7wvf F 46 3.91 URS0002617765_32630 36371424 32630 iiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiii .............................................. .............................................. ectoTLR3-mAb12-poly(I:C) complex; RNA (46-MER) 7wvj E 46 3.26 URS000261776A_32630 36371424 32630 cccccccccccccccccccccccccccccccccccccccccccccc .............................................. .............................................. NT-mut(K117D,K139D,K145D) TLR3 -poly I:C complex; RNA (46-MER) 7wvj F 46 3.26 URS0002617765_32630 36371424 32630 iiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiiii .............................................. .............................................. NT-mut(K117D,K139D,K145D) TLR3 -poly I:C complex; RNA (46-MER) 7x7r C 36 3.5 URS0002617772_237368 36302881 237368 ggacuuaaugucacgguacccaauuuucugccccgg .................................... .................................... Cryo-EM structure of a bacterial protein; RNA (36-MER) 7x7r J 20 3.5 URS000261778A_237368 36302881 237368 aguccggggcagaaaauugg .................... .................... Cryo-EM structure of a bacterial protein; RNA (5'-R(P*AP*GP*UP*CP*CP*GP*GP*GP*GP*CP*AP*GP*AP*AP*AP*AP*UP*UP*GP*G)-3') 7xam A 3062 3.5 RF02541 URS0000BC467B_246196 37709237 0003735 0005840 246196 aaguguuuaagggcgcaugguggaugccuuggcacugggagccgaugaaggacguaggaggcugcgauaagccucggggagcugucaaccgagcguugauccgaggauguccgaauggggaaacccggcacgagugaugucgugucaccaggcgcugaauauauaggcgucuggggggaacgcggggaagugaaacaucucaguacccguaggaagagaaaacaaaaugugauuccgugaguaguggcgagcgaaagcggaggauggcuaaaccguaugcaugugauaccggguagggguugugugugcgggguugugggaccuaucuuuccggcucuaccuggcuggagggcagugagaaaauguugugguuagcggaaauggcuugggauggccugccguagacggugagagcccgguacgugaaaacccgacgucugucuugaugguguucccgaguagcagcgggcccguggaaucugcugugaaucugccgggaccacccgguaagccugaauacuucccagugaccgauagcggauuaguaccgugagggaauggugaaaaguaccccgggaggggagugaaagaguaccugaaaccgugcgcuuacaauccgucagagcccucgacgugucguggggugauggcgugccuuuugaagaaugagccugcgagucagggacaugucgcgagguuaacccgggugggguagccgcagcgaaagcgagucugaauagggcguauccacacaagagugugugguguagugguguguucuggacccgaagcggagugaucuacccauggccagggugaagcgcggguaagaccgcguggaggcccgaacccacuuagguugaagacugaggggaugagcuguggguaggggugaaaggccaaucaaacuccgugauagcugguucuccccgaaaugcauuuaggugcagcgucgcauguuucuugccggagguagagcuacuggauggccgaugggccccacaggguuacugacgucagccaaacuccgaaugccgguaaguccaagagugcggcagugagacggcgggggauaagcuccgugcgucgagagggaaacagcccagaucgccggcuaaggccccuaagcgugugcuaaguggaaaaggaugugcagucgcgaagacaaccaggagguuggcuuagaagcagccacccuugaaagagugcguaauagcucacuggucaagugauugugcgccgauaauguagcggggcucaagcacaccgccgaagccgcggcagccaacguguuggcuggguaggggagcguccugcauccggugaagccgccgagugaucgagugguggagggugugggagugagaaugcaggcaugaguagcgauuaggcaagugagaaccuugcccgccgaaagaccaaggguuccugggccaggccaguccgcccagggugagucgggaccuaaggcgaggccgacaggcguagucgauggacaacggguugauauucccguacccguguaugugcguccaugaugaaucagcgguacuaaccauccaugggaccuucguugguaguagucaagcgauggggugacgcaggaagguagccguaccggucagugguaauaccgggguaagccuguagggagucagauagguaaauccgucuggcauauauccugagaggugaugcauagccgagugaggcgaauucggugauccuaugcugccgagaaaagccucuagcgaggacauacacggcccguaccccaaaccaacacagguggucagguagagaauacuaaggcguacgagugaacuaugguuaaggaacucggcaaaaugcccccguaacuucgggagaagggggacccacauggcguguaagccuuuacggcccaagcgugaguggguggcacaaaccagugagaagcgacuguuuacuaaaaacacagguccgugcgaagucgcaagacgauguauacggacugacgccugcccggugcuggaagguuaagaggacccguuaacucccuuugggggugaagcggagaauuuaagccccaguaaacggcgguggucauccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaacgacuucucaacugucucaaccauagacucggcgaaauugcacuacgaguaaagaugcucguuacgcgcggcaggacgaaaagaccccgggaccuucacuacaacuugguauuggugcucgauacgguuuguguaggauaggugggagacugugaagcucacacgccaguguggguggagucguuguugaaauaccacucugaucguauugggccucuaaccucggaccguauauccgguucagggacagugccugguggguaguuuaacuggggcgguugccuccuaaaauguaacggaggcgcccaaagguucccucaaccuggacggcaaucagguguugaguguaagugcacaagggagcuugacugcgagacggacaugucgagcagggacgaaagucgggacuagugauccggcaccucugaguggaaggggugucgcucaacggauaaaagguaccccggggauaacaggcugaucuuccccaagaguccauaucgacgggaugguuuggcaccucgaugucggcucgucgcauccuggggcuggagcaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguuuagaacgucgugagacaguucggucucuauccgccgcgcgcgucagaagcuugaggaaaccugucccuaguacgagaggaccgggacggacgaaccucugguauaccaguugucccaccaggggcacggcuggauagccacguucggacaggauaaccgcugaaagcaucuaagcgggaaaccucuuccaagaccaggcuucucacccucuaggagggauaaggccccccgcagaccacgggauugauagaccagaccuggaagccuaguaauaggugcagggaacuggcacuaaccggccgaaaacuuac <<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<<......<<<<<<.[[.(((.>>>.....<<<<<<<..<<<)))..]].>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<.....>>..<<<<<<.....<<.....>>....>>>>>>...<<<....<<<<<<<<<<.........(((((.....>>>>>>>>>>......<<<<..<.....<<<<<<<))))).>>>>>>><<<<<<.......<<<<<<.<<<<.<<<.....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>>>.....>...>>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..>>>......>>.>>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<<<<..>>>>.>>>>>..>>>>...<.<........>.>.<<<<<<....<<<.<<<<<<<<<<..<<<...<<<<..>>>>...>>>...<<....>>..<<<<.....>>>>....<<<<<<<....>>>>>>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<....<<<<<<<<.....<<<....<<<.<<<<....<<<<<<....>>>>>.>....>>>>.>>>..>>.>.....>>>>>>>>.......>>>>>>>.>>..<<<<<<<<<<......>>>>>>.>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..<<<<.......>>>>..>>>.........<<......>>...>>>>>....>>>>>>>>>.>>...........)))......>>>>>>.>>>...>>>>>>><<<<<<<<..>>>>>>>>....>>>>>><.<<<<<<<<<<......<<<<<<<<....>>>.>>>>>...>>>>>>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<.......<<<<...<<<<<<<......<<<<..>>>>.....>>>>>>>.....>>>>.<<...<<<<<...<<<<..<<<..<<<<..<<<<<...((((...>>>>>.<<..<<<<...<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>...>>>>...>>...<<<......>>>.....>>>>...>>>...>>>>........>>>>>..>>....>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<<...<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<...<<<<....<<<.....>>>....>>>>..>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<...<<....<<<..........<......<<...<<<<<<...>>>>>>....>>......>........>>>....>>...............................<<<<<.......>>>>>...........>>>>..>>.>>>>>>>..>..>>.>>>>>>>>>>>>>>>.....>.((..<<<<<......))>>>>>..<<<<<<<<.<<<.<<......<<<<<<<<<<..<<<<<.<<<.<<<<<.<<.<<<<<<<<<<<<.............<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>.>...>>>>>>>>>>>>.>>...<<<.<<<<<<......>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.<<..>>>>..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<.<<<<...<<.......>>...>>>>.>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))))>>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<<...>>>>>....<<<<.<<<<.......>>>>.....<<<.<<<<.<<<....<<<<<....>>>>>...>>>..>>>>..>>>...>>>>....>>>>.. ((((......((((((((((.....(((..(((((((((((((......((((((.[[.[[[.))).....((((((...(((]]]..]].)))......))))))...)))....(((....)))(((((((......))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))....((([...((((((((((.........[[[[[.....))))))))))....(.((((..(.....(((.((.]]]]]..)).))).(((((.......((((((.((((.(((...(.((((......)))))[[(...).(((.....]])))...)))...)))))))))))))))......)...))))]....(((((((...[.......)))))))....).(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((..(((((((((..)))).)))))..)))).<.(.(........).).((((((....(((.((((((((((..(((...(((....)))...)))...((....))..((((.....))))....(((((((....)))))))....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......A))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([.((((((((.....(((....(((.((((....(..(((....)))...)....)))).)))..)).).....))))))))....).]))))))).))..((((((((((......)))))).))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((.((((.....{.(((((.((([.(((.........)))..))).....(]..((......)).).)))))...)))).))))).))...........]]].)....))))))))))...)))))))((((((((..))))))))....))))))(.((((((((((......((((((((....))).)))))...))))))))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]]((((((((((.(.....(((...(.((.((.......((((..))))......)).)).).....))).((...(((((...((((..(((..((((..(((((....{{....))))).((..(((....(((((((((((.((.....))))))))).....))))..[.)))...))...(((......))).....))))...)))...))))(..)....)))))..))..).)))))))))))))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((...((((....((((..)])))....))))..))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}(((....(....(((..........(..............(((...)))...............)........))).....)..(........).............(.....(((((.......))))).......)...)))...)).))))))).)..))).)))))))).)))))).....))[[..(((((.....>]])))))..((((((((.(((.((......((((((((((..(((((.(((.(((((.((.((((.(((((.(..(.........(.(((...((......((.((.((....)).)).))...)).............))).))..).))))).)))).))...(((.((((((......)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.(.((((...((.......))...)))).)...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))..a.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..(((((...)))))....((((.((((.......)))).....(((.((((.(((....(((((....)))))...)))..))))..)))...))))....)))).. Mycobacterium smegmatis 50S ribosomal subunit from Stationary phase of growth; 23S rRNA 7xam B 118 3.5 RF00001 URS00000ACC0A_246196 37709237 0003735 0005840 246196 guuacggcgguccauagcggcagggaaacgcccggucccaucccgaacccggaagcuaagccugccagcgccgaugauacuacccauccggguggaaaaguaggacaccgccgaacac <<<.<<<<<<<.....<<<<<<<<.....<<<<<<.............>>>>..>>....>>>>>>.>>.<<.......<<<<<<....>>>>>>.......>>..>>>>>>>>>>.. (((.(((((((.....((((((((.....((((((...(.....)...))))..))....)))))).)).((.......((((((....)))))).......))..)))))))))).. Mycobacterium smegmatis 50S ribosomal subunit from Stationary phase of growth; 5S rRNA 7xc7 C 31 3.1 URS0002617783_237368 36302881 237368 cuuaaugucacgguacccaauuuucugcccc ............................... ............................... Cryo-EM structure of a bacterial protein complex; RNA (33-MER) 7xc7 J 19 3.1 URS000261778A_237368 36302881 237368 ggggcagaaaauuggacga ................... ................... Cryo-EM structure of a bacterial protein complex; RNA (46-mer) 7xd5 N 400 2.84 RF00028 URS00026813DA_5911 0000372 5911 uuuggagggaaaaguuaucaggcaugcaccugguagcuagucuuuaaaccaauagauugcaucgguuuaaaaggcaagaccgucaaauugcgggaaaggggucaacagccguucaguaccaagucucaggggaaacuuugagauggccuugcaaaggguaugguaauaagcugacggacaugguccuaaccacgcagccaaguccuaagucaacagaucuucuguugauauggaugcaguucacagacuaaaugucggucggggaagauguauucuucucauaagauauagucggaccucuccuuaaugggagcuagcggaugaagugaugcaacacuggagccgcugggaacuaauuuguaugcgaaaguauauugauuaguuuuggaguacucguaag ............<<<<<<<<<<..[((.>>>>>>>>>>.<<<<<<<<<<<......<<<<<<.>>>>>>.>>>>>..<<<<<.<....<<<<<<...<<<<<<.....<<<.<<<<.<<...<<<<<<<<<....>>>>>>>>>..<<..)).].>>.....>>......>>>>>>>....>>>>>>..>>.>>>><<...<<<<...<<<<<<<<<...>>>>>>>>>..>>>>...>>.....(((((...>.>>>>>.<<<<<<<.....>>>>>>>........))))).((((.<<<<<....>>>>><<<<<<<....<<<<>>>>>>>>>>....>>>>>>>.<<<<<<<<.<<<<<......>>>>>.>>>>>>>>..)).....))..... ............((((((((((..{{{.)))))))))).(((((((((((....(.[[[[[[))))))).)))))..(((((.(....((((((...((((((.....(((.((((.(((..(((((((((....)))))))))..((..}}.}.))....)))......)))))))....))))))..)).))))((...((((...(((((((((...)))))))))..))))...))...[.[[[[[...).))))).(((((((.....)))))))........]]]]]]((((.(((((....)))))(((((((.....(((]]]]]]))).....))))))).(((((((..((((.(....).))))..)))))))..)).....))..... The Tet-S2 state of wild-type Tetrahymena group I intron with 30nt 3'/5'-exon; The Tet-S2 state molecule of co-transcriptional folded wild-type Tetrahymena group I intron with 30nt 3'/5'-exon (intron and 3'-exon) 7xd6 N 434 2.84 RF00028 URS00026813D8_5911 0000372 5911 auagcaauauuuaccuuuggagggaaaaguuaucaggcaugcaccugguagcuagucuuuaaaccaauagauugcaucgguuuaaaaggcaagaccgucaaauugcgggaaaggggucaacagccguucaguaccaagucucaggggaaacuuugagauggccuugcaaaggguaugguaauaagcugacggacaugguccuaaccacgcagccaaguccuaagucaacagaucuucuguugauauggaugcaguucacagacuaaaugucggucggggaagauguauucuucucauaagauauagucggaccucuccuuaaugggagcuagcggaugaagugaugcaacacuggagccgcugggaacuaauuuguaugcgaaaguauauugauuaguuuuggaguacucguaagguagccaaaugccucguca ............<<.............<<<<<<<<<<..[((.>>>>>>>>>>.<<<<<<<<<<<......<<<<<<.>>>>>>.>>>>>..<<<<<.<....<<<<<<...<<<<<<.....<<<.<<<<.<<...<<<<<<<<<....>>>>>>>>>..<<..)).].>>.....>>......>>>>>>>....>>>>>>..>>.>>>><<...<<<<...<<<<<<<<<...>>>>>>>>>..>>>>...>>.....(((((...>.>>>>>.<<<<<<<.....>>>>>>>........))))).((((.<<<<<....>>>>><<<<<<<....<<<<>>>>>>>>>>....>>>>>>>.<<<<<<<<..<<<<......>>>>..>>>>>>>>..)).....)).....>>................. ............((.............((((((((((..{{{.)))))))))).(((((((((((....(.[[[[[[))))))).)))))..(((((.(....((((((...((((((.....(((.((((.(((..(((((((((....)))))))))..((..}}.}.))....)))......)))))))....))))))..)).))))((...((((...(((((((((...)))))))))..))))...))...[.[[[[[...).))))).(((((((.....)))))))........]]]]]]((((.(((((....)))))(((((((.....(((]]]]]]))).....))))))).((((((((..(((((....)))))..))))))))..)).....)).....))..(.....)........ The Tet-S2 state with a pseudoknotted 4-way junction of wild-type Tetrahymena group I intron with 30nt 3'/5'-exon; The Tet-S2 state with a pseudoknotted 4-way junction molecule of co-transcriptional folded wild-type Tetrahymena group I intron with 30nt 3'/5'-exon (intron and 3'-exon) 7xd6 A 25 2.84 URS00007A6AB3_5911 5911 acggcgggaguaacuaugacucucu ......................... ......................... The Tet-S2 state with a pseudoknotted 4-way junction of wild-type Tetrahymena group I intron with 30nt 3'/5'-exon; The Tet-S2 state with a pseudoknotted 4-way junction molecule of co-transcriptional folded wild-type Tetrahymena group I intron with 30nt 3'/5'-exon (5'-exon) 7xd8 B 12 2.85 URS00026177B2_32630 36577062 32630 acgauuauaucc ............ ............ Crystal Structure of Dengue Virus Serotype 2 (DENV2) Polymerase Elongation Complex (Native Form); RNA (30-mer) 7xd8 E 11 2.85 URS00026177B2_32630 36577062 32630 cgauuauaucc ........... ........... Crystal Structure of Dengue Virus Serotype 2 (DENV2) Polymerase Elongation Complex (Native Form); RNA (30-mer) 7xd8 H 11 2.85 URS00026177B2_32630 36577062 32630 cgauuauaucc ........... ........... Crystal Structure of Dengue Virus Serotype 2 (DENV2) Polymerase Elongation Complex (Native Form); RNA (30-mer) 7xd8 K 12 2.85 URS00026177B2_32630 36577062 32630 acgauuauaucc ............ ............ Crystal Structure of Dengue Virus Serotype 2 (DENV2) Polymerase Elongation Complex (Native Form); RNA (30-mer) 7xd8 N 12 2.85 URS00026177B2_32630 36577062 32630 acgauuauaucc ............ ............ Crystal Structure of Dengue Virus Serotype 2 (DENV2) Polymerase Elongation Complex (Native Form); RNA (30-mer) 7xd8 Q 11 2.85 URS00026177B2_32630 36577062 32630 cgauuauaucc ........... ........... Crystal Structure of Dengue Virus Serotype 2 (DENV2) Polymerase Elongation Complex (Native Form); RNA (30-mer) 7xd9 B 12 2.58 URS00026177B2_32630 36577062 32630 acgauuauaucc ............ ............ Crystal Structure of Dengue Virus serotype 2 (DENV2) Polymerase Elongation Complex (CTP Form); RNA (30-mer) 7xd9 E 13 2.58 URS00026177B2_32630 36577062 32630 aacgauuauaucc ............. ............. Crystal Structure of Dengue Virus serotype 2 (DENV2) Polymerase Elongation Complex (CTP Form); RNA (30-mer) 7xd9 H 12 2.58 URS00026177B2_32630 36577062 32630 acgauuauaucc ............ ............ Crystal Structure of Dengue Virus serotype 2 (DENV2) Polymerase Elongation Complex (CTP Form); RNA (30-mer) 7xd9 K 16 2.58 URS00026177B2_32630 36577062 32630 ggcaacgauuauaucc ................ .()............. Crystal Structure of Dengue Virus serotype 2 (DENV2) Polymerase Elongation Complex (CTP Form); RNA (30-mer) 7xd9 N 19 2.58 URS00026177B2_32630 36577062 32630 gggaccaacgauuauaucc .<<.>>............. .((.))............. Crystal Structure of Dengue Virus serotype 2 (DENV2) Polymerase Elongation Complex (CTP Form); RNA (30-mer) 7xd9 Q 12 2.58 URS00026177B2_32630 36577062 32630 acgauuauaucc ............ ............ Crystal Structure of Dengue Virus serotype 2 (DENV2) Polymerase Elongation Complex (CTP Form); RNA (30-mer) 7xjg E 58 2.51 URS0002616B7B_562 35982312 562 cccuuagcgagagguccucuggauguuguuucggcauccugcauugaaucugaguuac .........<<<<...>>>><<<<<<<.....>>>>>>>................... ........((((((.)))))((((((((...))))))))..)................ Cryo-EM structure of E.coli retron-Ec86 in complex with its effector at 2.5 angstrom; RNA (81-MER) 7xjg H 58 2.51 URS0002616B7B_562 35982312 562 cccuuagcgagagguccucuggauguuguuucggcauccugcauugaaucugaguuac .........<<<<...>>>><<<<<<<.....>>>>>>>................... ........((((((.)))))((((((((...))))))))..)................ Cryo-EM structure of E.coli retron-Ec86 in complex with its effector at 2.5 angstrom; RNA (81-MER) 7xnx L1 3773 2.7 RF02543 URS00023359CB_9606 36259929 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagngngaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcggcccggcggaucuuucccgcgcgggggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcunggaaggcccggcggggaagguggcucgggggcccccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcncucuccccccucccggcgcgccggggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccgggggaggccacgcgcgcgucccccgaagagggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccnucuugnaacncggaccaaggagunuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgagggngcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuagnacccnanagauggugancuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauagnggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcagacccgacgcccgccacgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcngaacuggcgnugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagcggcgggccggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaunuuggugguagunnnaaauauucaaacgagaacuuugaaggccgaaguggngaaggguuccaugugaacagnanuugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccnuauccgcagcaggucuncaaggugaacngccucuggnauguuggaacaanguagguaagggaagucggcaagcnggauccguaacuucnggauaaggauuggcucuaagggcugggucggucgcggccggcgccuagcagccgacuuagaacuggugcggaccaggngaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugccnagugcucugaaugucanagugnagaaauucaaugaagcgcggnuaaacggcgggaguaacnaugacucucuuaagguagcnaanugccucnucaucuaauuagugangcgcaugaanggaugancgagnuucccacugunccuaccuacuauccagcgaaaccacngncaagggaacgggcuuggnggaaucagcggngaaagaagacccuguugagcuugacncuagucuggcacggugaanagacaugagagguguagaauaagugggaggcccccggcgcccccccgguguccccgcgaggggcccggggcgggguccgccggcccugcgggccgccggugaaauaccacuacucugaucguuuuuucacugacccggugaggcgggggggcgagccccgaggggcucucgcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacugnggcgguacaccugucaaacgguancgcaggnnuccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucagnacgaauacagaccgugaaagcggggccunacgauccuucugaccuuuuggguuuuaagcaggangugucagaaaaguuaccacagngauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuungaugucggnucuuccuaucauugugaagcagaauucaccaagcguungaunnuucacccacuaauagggaacgugngcugggnuuagancgucgugagacagguuaguuuuacccuacugaugnuguguuguugccaugguaauccugcucaguacgagaggaaccgcagnuncanacauuugguguaunugcuuggcugaggagccaauggggcgaagcuacnaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccggucccccgccgggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..[[[..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>>..<<<<<<<<<....<<<.<<<<.<......<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>..>>>>.>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<......>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<<<..<<<<<<<.<<<<..<<....<<<<.<<<..<<<<..>>>>>>>>>>>>>..>>>>>>>>...>>>>>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<<<<<<<<<<<<<<<<<...<<..<<<....<<<<......<<<<<<<<..>>>>>>>>.......>>>>...>>>........>>>>>>..>>>>>>>>>>>....................<<<<<<.<<<<<<<.....<..>...>>>>>>>.<<<<<<.<<<<.<<<<<<<<<<<.<<<<<.<<<<<<<...........>.>>>>>>.>>>>>.>.>>>>>>>.>>>...>>>>..>>>>.>>..<<<<<<<<<<.....>>>>>>>>.>>....>>>>>>.....>>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<......>>>>>>>..<<<<<...<<<..<<<..[[....(((>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<......................<<<.<<<<<<<<<...<<<....<<<..<.<<<<....<.............>..>>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<..........)))....]]............................>>>>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<...........>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<..<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..{{{..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<..<<..........>>.......>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<<.<<<<<<<<.<.<...............................................................................................................>..>.>>>>>>>>...<<<<<.....<<<<.....<<.<<......>>.>>................<<<<<<<<<<.......>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>><<<<....>>>>>>)))]......((((((..(((..>>>>>>.)))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]].....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<}}}.>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.....<<<<<<<.<<..<<<<....<<<........<<<<<.<<<<....>>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>..............>>>>..>>>>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<.<..<<<<<......>>>>>..>>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((...((((((((((.....)))))).)))).....)))....((((((((((...(((.((((.(.(....((((((((..({((((......)))))....[[(...).(((....}]])))...).)))))))).)))).))))..))))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....(((((((((((..(((((((.(.((..((....((((.(((...(.(..).).)))))))))..)).)))))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((.((.((((......(((((((.().))))))).......))))).))))........))))))..)))))))))))....................((((((.((((((.....(.....)..)))))).((((((.((((.((((((((((..(((((.(((((................))))).)))))...))))))).)))...))).).)))).))..((((((((((.....)))))))).))..[.)))))).....))).)))))...)))))...)))))))).<((((........))))((((((..(.(((((((((((((..(((..(((((........))))..)..)))...((....))...(((((((......)))))))..(((((...(((..(((..[.....[.[)))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))..).))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((.(((((((......................(((.((((((((....(((....(((..(.(((..(..................).))).)..)))..)).)....))))))...(((((((((.(......))))))))))....))))))))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.....{.(((((.(.(...((.........))....)).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((...........]].....]]..(.(.)..)....(...)........)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((..(((((((...((.....)).))))))....[[(((.((...(.....(((....)))..........((.((((....(....)...)))))).......)....))...(((((........)))))]]((((....(((((...(((((((....)))))))..((((....)))...(...((((((...(((((((((((((((((((((((..{{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....(((((((.......))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).))).))).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((...(.(.......))........)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(...(......(((......)))......).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.(((((((((.(((((((.........(....................................(.................)..............................................)..........)))))))...(((((.....(((((....((............)).)..............((((((((((.......))))))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(..((..((((....{..))))..)).)(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......(....(.((((((...((.......))...))))))...)....)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a.))..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}}.)))))..)).))...))))...)))).((((...((((.....}.......))))...))))..)))...).)))))).....(((((((.((..((((.(..(((........(((((.((((....)))).))))).......)))...(((..((((....((((.(((((((......)))))))))))...))))..)))...........)..))))..)))))))))(((((.(..(.......)..)....((.(((((((.((.....((((.(..(((((......)))))..)))))....))....)))).))).))..))))).. High resolution cry-EM structure of the human 80S ribosome from SNORD127+/+ Kasumi-1 cells; 28S rRNA 7xnx L2 120 2.7 RF00001 URS00000F9D45_9606 36259929 0003735 0005840 9606 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. High resolution cry-EM structure of the human 80S ribosome from SNORD127+/+ Kasumi-1 cells; 5S rRNA 7xnx L3 156 2.7 RF00002,RF02540 URS0000005270_9606 36259929 0003735 0005840 9606 cgacucuuagcggnggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauuncaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<<<<....>>>>.....<.<<<......>>.............>>>..>...>>>....<<....>><<<<<<<<<.....>>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))(((((((((.....))))))))).................... High resolution cry-EM structure of the human 80S ribosome from SNORD127+/+ Kasumi-1 cells; 5.8S rRNA 7xnx S2 1740 2.7 RF01960,RF02542,RF01959,RF00177 URS00026813DB_9606 36259929 0003735 0005840 9606 uaccugguugauccugccaguagcaunugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucnuuaaaucaguuauggunccuunggucgcucgcuccucucccacuuggauaacugugguanuucuagngcuaananaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgccccccguggcggcgacgacccauucgaacgucngcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgaunccggaganggagccugagaaacggcuaccacauncaaggnaggcagcaggcgcgcnaauuacccacucccgacccggggangungugangaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaanuccuuuaacgaggnuccauuggagngcaagucuggugccagcagccgcgguaauuccagcuccaauancguauauuaaaguugcugcaguunaaaagcucguaguungaucuugggagcgggcguccccgcccucucggccggggcccgaagcguuuacuuugaaaaaanuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaaungaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagancgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccacnaggaguggagccugcggcuuaauuugacncaacacgggaaaccucacccggcncggacacggacagganugacagauugauagcucuuucucgauuccguggguggngnugcauggcnguucuuaguugguggagcgauuugucugguuaauucngauaacgancgagacunuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuncuuanagggacaaguggcguucagccacccgagauugagcaauaacangucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauunagucccugcccuuuguacacaccgnccgucgnuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggucggcccacggcccuggcggagcgcugagaagacggucgaacuugncuaucuagaggaaguaaaagucgnancaagguuucnguaggugnnccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<....<<....<<<<<..................<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<........>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<<......>>>>>>>>.>>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....<<.<..<<<.<<<....>>>.>>.>...>.>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<.......................<<.<.............>>>...<<<<<<.<.......<<...<.......>.<<<<.......>>>>...>>......>.>>>..>>>........<.<<.<<<<<<<...............>>>>>>>.>>.>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<......>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<......<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<.......>>>>.>>>>.....>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.......>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<....<<...................>>......>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((..((....((....((..(.).....))...))[))......(((.......(((.(.(..((....((((....((.............((.....((.(((.....))).))......))......)).((((...((((........))))...))))((..(((((...(......)..)))))......)).(.((((.(((.(.....))))))))).).)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).).....(.(((..((.(((....))).))...).).))....(.((..(...........)..))......)..((((([[....(.((((.....((..]])).......))))))))))..)))))).)))..[......(.([[...(.(.((...(((..(.......................((................))...((((((.(.......((..((.......)).((.(......)))....))......).)))..)))........(.((.(.(..(.................)..).).)).)....)....(((.(((..(...((((..(((.((((((((...((........))......)))))))).))).......((....))...))))..)..)))..))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.((((......)))))))))).)..)))...((..]]))...))...].))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))........(.(((((..(...(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((...(...((((..((((((((((((.......)))).)))).....))))..))))..).....(((((.....)))))........)))....))).))).....).))))).....).))))))..)).)))).))).(...((.(((........(.......((..((((....))))..))....).........))).))......(.....(((((..........))))).....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..((((.((...(((((....(...(............)....)......)))))...)).))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}........ High resolution cry-EM structure of the human 80S ribosome from SNORD127+/+ Kasumi-1 cells; 18S rRNA 7xnx CC 75 2.7 RF00005 URS0000E60BA3_9606 36259929 0030533 0006412 9606 uccgauauagcguaacggcuaucacaucacgcuuucaccguggagaccgggguucgacuccccguaucggagcca <<<<<<<..<.<..........>.>.<<<<<.......>>>>>....<<<<<.......>>>>>>>>>>>>.... (((((((..(.(.....[....).).(((((.......)))).)...(((((..]....)))))))))))).... High resolution cry-EM structure of the human 80S ribosome from SNORD127+/+ Kasumi-1 cells; tRNA 7xny L1 3773 2.5 RF02543 URS00023359CB_9606 36259929 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagngngaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcggcccggcggaucuuucccgcgcgggggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcunggaaggcccggcggggaagguggcucgggggcccccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcncucuccccccucccggcgcgccggggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccgggggaggccacgcgcgcgucccccgaagagggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccnucuugnaacncggaccaaggagunuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgagggngcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuagnacccnanagauggugancuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauagnggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcagacccgacgcccgccacgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcngaacuggcgnugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagcggcgggccggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaunuuggugguagunnnaaauauucaaacgagaacuuugaaggccgaaguggngaaggguuccaugugaacagnanuugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccnuauccgcagcaggucuncaaggugaacngccucuggnauguuggaacaanguagguaagggaagucggcaagcnggauccguaacuucnggauaaggauuggcucuaagggcugggucggucgcggccggcgccuagcagccgacuuagaacuggugcggaccaggngaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugccnagugcucugaaugucanagugnagaaauucaaugaagcgcggnuaaacggcgggaguaacnaugacucucuuaagguagcnaanugccucnucaucuaauuagugangcgcaugaanggaugancgagnuucccacugunccuaccuacuauccagcgaaaccacngncaagggaacgggcuuggnggaaucagcggngaaagaagacccuguugagcuugacncuagucuggcacggugaanagacaugagagguguagaauaagugggaggcccccggcgcccccccgguguccccgcgaggggcccggggcgggguccgccggcccugcgggccgccggugaaauaccacuacucugaucguuuuuucacugacccggugaggcgggggggcgagccccgaggggcucucgcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacugnggcgguacaccugucaaacgguancgcaggnnuccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucagnacgaauacagaccgugaaagcggggccunacgauccuucugaccuuuuggguuuuaagcaggangugucagaaaaguuaccacagngauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuungaugucggnucuuccuaucauugugaagcagaauucaccaagcguungaunnuucacccacuaauagggaacgugngcugggnuuagancgucgugagacagguuaguuuuacccuacugaugnuguguuguugccaugguaauccugcucaguacgagaggaaccgcagnuncanacauuugguguaunugcuuggcugaggagccaauggggcgaagcuacnaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccggucccccgccgggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..[[[..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>>..<<<<<<<<<....<<<.<<<<.<......<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>..>>>>.>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<<<..<<<<<<<.<<<<..<<....<<<<.<<<..<<<<..>>>>>>>>>>>>>..>>>>>>>>...>>>>>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<<<<<<<<<<<<<<<<<...<<..<<<....<<<<......<<<<<<<<..>>>>>>>>.......>>>>...>>>........>>>>>>..>>>>>>>>>>>....................<<<<<<.<<<<<<<.....<..>...>>>>>>>.<<<<<<.<<<<.<<<<<<<<<<<.<<<<<.<<<<<<<...........>.>>>>>>.>>>>>.>.>>>>>>>.>>>...>>>>..>>>>.>>..<<<<<<<<<<.....>>>>>>>>.>>....>>>>>>.....>>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<......>>>>>>>..<<<<<...<<<..<<<..[[....(((>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<......................<<<.<<<<<<<<<...<<<....<<<....<<<<....<.............>..>>>>....>>>..>.>>...>>>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<......<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>....>>>>>..>>>...>>>>>>><<<<<<.<<<..........)))....]]............................>>>>>>>>>....>>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<...........>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<..<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..{{{..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<..<<..........>>.......>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<<.<<<<<<<<.<.<...............................................................................................................>..>.>>>>>>>>...<<<<<.....<<<<..<<.<<.<<......>>.>>>>..............<<<<<<<<<<.......>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>><<<<....>>>>>>)))]......((((((..(((..>>>>>>.)))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]].....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<}}}.>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.....<<<<<<<.<<..<<<<....<<<........<<<<<.<<<<....>>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>..............>>>>..>>>>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<.<..<<<<<......>>>>>..>>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((...((((((((((.....)))))).)))).....)))....((((((((((...(((.((((.(.(....((((((((..({((((......)))))....[[(...).(((....}]])))...).)))))))).)))).))))..))))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....(((((((((((..(((((((.(.((..((....((((.(((...(.(..).).)))))))))..)).)))))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((.((.((((......((((.((.().).))))).......))))).))))........))))))..)))))))))))....................((((((.((((((.....(.....)..)))))).((((((.((((.((((((((((..(((((.(((((................))))).)))))...))))))).)))...))).).)))).))..((((((((((.....)))))))).))..[.)))))).....))).)))))...)))))...)))))))).<((((........))))((((((..(.(((((((((((((..(((..(((((........))))..)..)))...((....))...(((((((......)))))))..(((((...(((..(((..[.....[[[)))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))..).))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((.(((((((......................(((.((((((((....(((....(((..(.(((..(..................).))).)..)))..)).)....))))))...(((((((((.(......))))))))))....))))))))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.....{.(((((.(.(...((.........))....)).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((..........]]].....]]..(.(.)..)....(...)........)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((..(((((((...((.....)).))))))....[[(((.((...(.....(((....)))..........((.(((((...(....)..))))))).......)....))...(((((........)))))]]((((....(((((...(((((((....)))))))..((((....)))...(...((((((...(((((((((((((((((((((((..{{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....(((((((.......))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).))).))).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((...(.(.......))........)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(..((......(((......)))......)))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.(((((((((.(((((((.........(....................................(.................)..............................................)..........)))))))...(((((.....((((..((.((............))))..............((((((((((.......))))))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(..((..((((....{..))))..)).)(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......(....(.((((((...((.......))...))))))...)....)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a.))..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}}.)))))..)).))...))))...)))).((((...((((.....}.......))))...))))..)))...).)))))).....(((((((.((..((((.(..(((........(((((.((((....)))).))))).......)))...(((..((((....((((.(((((((......)))))))))))...))))..)))...........)..))))..)))))))))(((((.(..(.......)..)....((.(((((((.((.....((((.(..(((((......)))))..)))))....))....)))).))).))..))))).. High resolution cry-EM structure of the human 80S ribosome from SNORD127+/- Kasumi-1 cells; 28S rRNA 7xny L2 120 2.5 RF00001 URS000002B0D5_9606 36259929 0003735 0005840 9606 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. High resolution cry-EM structure of the human 80S ribosome from SNORD127+/- Kasumi-1 cells; 5S rRNA 7xny L3 156 2.5 RF00002,RF02540 URS00004B2C76_9606 36259929 0003735 0005840 9606 cgacucuuagcggnggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauuncaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<<<<....>>>>.....<.<<<......>>.............>>>..>...>>>....<<....>><<<<<<<<<.....>>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))(((((((((.....))))))))).................... High resolution cry-EM structure of the human 80S ribosome from SNORD127+/- Kasumi-1 cells; 5.8S rRNA 7xny S2 1740 2.5 RF01960,RF02542,RF01959,RF00177 URS00026813DB_9606 36259929 0003735 0005840 9606 uaccugguugauccugccaguagcaunugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucnuuaaaucaguuauggunccuunggucgcucgcuccucucccacuuggauaacugugguanuucuagngcuaananaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgccccccguggcggcgacgacccauucgaacgucngcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgaunccggaganggagccugagaaacggcuaccacauncaaggnaggcagcaggcgcgcnaauuacccacucccgacccggggangungugangaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaanuccuuuaacgaggnuccauuggagngcaagucuggugccagcagccgcgguaauuccagcuccaauancguauauuaaaguugcugcaguunaaaagcucguaguungaucuugggagcgggcguccccgcccucucggccggggcccgaagcguuuacuuugaaaaaanuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaaungaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagancgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccacnaggaguggagccugcggcuuaauuugacncaacacgggaaaccucacccggcncggacacggacagganugacagauugauagcucuuucucgauuccguggguggngnugcauggcnguucuuaguugguggagcgauuugucugguuaauucngauaacgancgagacunuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuncuuagagggacaaguggcguucagccacccgagauugagcaauaacangucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauunagucccugcccuuuguacacaccgnccgucgnuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggucggcccacggcccuggcggagcgcugagaagacggucgaacuugncuaucuagaggaaguaaaagucgnancaagguuucnguaggugnnccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<....<<....<<<<<..................<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<........>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<<......>>>>>>>>.>>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....<<.<...<<.<<<....>>>.>>.....>.>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<.......................<<.<.............>>>...<<<<<<.<.......<<...<.......>.<<<<.......>>>>...>>......>.>>>..>>>........<.<<.<<<<<<<...............>>>>>>>.>>.>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<......<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<.......>>>>.>>>>.....>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.......>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<....<<...................>>......>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((..((....((....((..(.).....))...))[))......(((.......(((.(.(..((....((((....((.............((.....((.(((.....))).))......))......)).((((...((((........))))...))))((..(((((...(......)..)))))......)).(.((((.(((.(.....))))))))).).)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).).....(.(((..((.(((....))).))...).).))....(.((..(...........)..))......)..((((([[....(.((((.....((..]])).......))))))))))..)))))).)))..[......(.([[...(.(.((...(((..(.......................((................))...((((((.(.......((..((.......)).((.(......)))....))......).)))..)))........(.((.(.(..(.................)..).).)).)....)....(((.((...(...((((..(((.((((((((...((........))......)))))))).))).......((....))...))))..)...))..))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.((((......)))))))))).)..)))...((..]]))...))...].))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((...(...((((..((((((((((((.......)))).)))).....))))..))))..).....(((((.....)))))........)))....))).))).....).))))).....).)))))...)).)))).))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..((((.((...(((((....(...(.(......)...)....)......)))))...)).))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}........ High resolution cry-EM structure of the human 80S ribosome from SNORD127+/- Kasumi-1 cells; 18S rRNA 7xpl G 25 2.213 URS0002617723_2287 36127125 2287 gagucugaacacucauggucuucgc ......................... ......................... Crystal structure of a C/D-free RNA-guided RNA 2'-O-methyltransferase; BMG3 RNA strand A 7xpl H 25 2.213 URS000261771E_2287 36127125 2287 gcgauggaacacucaugguagacuc ......................... ......................... Crystal structure of a C/D-free RNA-guided RNA 2'-O-methyltransferase; BMG3 RNA strand B 7xpl I 11 2.213 URS0000A7639F_2287 36127125 2287 ccaugaguguu ........... ........... Crystal structure of a C/D-free RNA-guided RNA 2'-O-methyltransferase; RNA (5'-R(*CP*CP*AP*UP*GP*AP*GP*UP*GP*UP*U)-3') 7xpl J 11 2.213 URS0000A7639F_2287 36127125 2287 ccaugaguguu ........... ........... Crystal structure of a C/D-free RNA-guided RNA 2'-O-methyltransferase; RNA (5'-R(*CP*CP*AP*UP*GP*AP*GP*UP*GP*UP*U)-3') 7xsp A 15 2.89 URS0002617789_237368 36306795 237368 ggggcagaaaauugg ............... ............... Structure of gRAMP-target RNA; RNA (5'-R(P*GP*GP*GP*GP*CP*AP*GP*AP*AP*AP*AP*UP*UP*GP*G)-3') 7xsp D 35 2.89 URS0002617787_237368 36306795 237368 gacuuaaugucacgguacccaauuuucugccccgg ................................... ................................... Structure of gRAMP-target RNA; RNA (35-MER) 7xsr A 15 2.97 URS0002617789_237368 36306795 237368 ggggcagaaaauugg ............... ............... Structure of Craspase-target RNA; RNA (5'-R(P*GP*GP*GP*GP*CP*AP*GP*AP*AP*AP*AP*UP*UP*GP*G)-3') 7xsr D 34 2.97 URS0002617787_237368 36306795 237368 gacuuaaugucacgguacccaauuuucugccccg .................................. .................................. Structure of Craspase-target RNA; RNA (34-MER) 7xss A 20 3.2 URS000261778A_237368 36306795 237368 ggggcagaaaauuggacgau .................... .................... Structure of Craspase-CTR; RNA (5'-R(P*GP*GP*GP*GP*CP*AP*GP*AP*AP*AP*AP*UP*UP*GP*GP*AP*CP*GP*AP*U)-3') 7xss D 34 3.2 URS0002617787_237368 36306795 237368 gacuuaaugucacgguacccaauuuucugccccg .................................. .................................. Structure of Craspase-CTR; RNA (34-MER) 7xt4 a 21 3.08 URS000261775B_237368 36306795 237368 ggggcagaaaauuggguaccg ..................... ..................... Structure of Craspase-NTR; RNA (5'-R(P*GP*GP*GP*GP*CP*AP*GP*AP*AP*AP*AP*UP*UP*GP*GP*GP*UP*AP*CP*CP*G)-3') 7xt4 r 34 3.08 URS000261775D_237368 36306795 237368 gacuuaaugucacgguacccaauuuucugccccg .................................. .................................. Structure of Craspase-NTR; RNA (34-MER) 7y2b S 13 1.88 URS000268140B_32630 37245780 32630 uucugcugcugaa ............. ............. Crystal structure of CUG repeat RNA duplex containing U-U mismatches; RNA (5'-R(P*UP*UP*CP*UP*GP*CP*UP*GP*CP*UP*GP*AP*A)-3') 7y2p A 13 1.58 URS000268140B_32630 37245780 32630 uucugcugcugaa ............. ............. Crystal structure of CUG repeat RNA duplex containing A-U base pair and U-U mismatches; RNA (5'-R(P*UP*UP*CP*UP*GP*CP*UP*GP*CP*UP*GP*AP*A)-3') 7y2p B 13 1.58 URS0002681411_32630 37245780 32630 uucugcagcugaa ............. ............. Crystal structure of CUG repeat RNA duplex containing A-U base pair and U-U mismatches; RNA (5'-R(P*UP*UP*CP*UP*GP*CP*AP*GP*CP*UP*GP*AP*A)-3') 7y41 A 3119 4.1 RF02541 URS0000BC467B_246196 37709237 0003735 0005840 246196 aaguguuuaagggcgcaugguggaugccuuggcacugggagccgaugaaggacguaggaggcugcgauaagccucggggagcugucaaccgagcguugauccgaggauguccgaauggggaaacccggcacgagugaugucgugucaccaggcgcugaauauauaggcgucuggggggaacgcggggaagugaaacaucucaguacccguaggaagagaaaacaaaaugugauuccgugaguaguggcgagcgaaagcggaggauggcuaaaccguaugcaugugauaccggguagggguugugugugcgggguugugggaccuaucuuuccggcucuaccuggcuggagggcagugagaaaauguugugguuagcggaaauggcuugggauggccugccguagacggugagagcccgguacgugaaaacccgacgucugucuugaugguguucccgaguagcagcgggcccguggaaucugcugugaaucugccgggaccacccgguaagccugaauacuucccagugaccgauagcggauuaguaccgugagggaauggugaaaaguaccccgggaggggagugaaagaguaccugaaaccgugcgcuuacaauccgucagagcccucgacgugucguggggugauggcgugccuuuugaagaaugagccugcgagucagggacaugucgcgagguuaacccgggugggguagccgcagcgaaagcgagucugaauagggcguauccacacaagagugugugguguagugguguguucuggacccgaagcggagugaucuacccauggccagggugaagcgcggguaagaccgcguggaggcccgaacccacuuagguugaagacugaggggaugagcuguggguaggggugaaaggccaaucaaacuccgugauagcugguucuccccgaaaugcauuuaggugcagcgucgcauguuucuugccggagguagagcuacuggauggccgaugggccccacaggguuacugacgucagccaaacuccgaaugccgguaaguccaagagugcggcagugagacggcgggggauaagcuccgugcgucgagagggaaacagcccagaucgccggcuaaggccccuaagcgugugcuaaguggaaaaggaugugcagucgcgaagacaaccaggagguuggcuuagaagcagccacccuugaaagagugcguaauagcucacuggucaagugauugugcgccgauaauguagcggggcucaagcacaccgccgaagccgcggcagccaacguguuggcuggguaggggagcguccugcauccggugaagccgccgagugaucgagugguggagggugugggagugagaaugcaggcaugaguagcgauuaggcaagugagaaccuugcccgccgaaagaccaaggguuccugggccaggccaguccgcccagggugagucgggaccuaaggcgaggccgacaggcguagucgauggacaacggguugauauucccguacccguguaugugcguccaugaugaaucagcgguacuaaccauccaaaaccaccgugaccgcaccuuucgggguguggcguugguggggcugcaugggaccuucguugguaguagucaagcgauggggugacgcaggaagguagccguaccggucagugguaauaccgggguaagccuguagggagucagauagguaaauccgucuggcauauauccugagaggugaugcauagccgagugaggcgaauucggugauccuaugcugccgagaaaagccucuagcgaggacauacacggcccguaccccaaaccaacacagguggucagguagagaauacuaaggcguacgagugaacuaugguuaaggaacucggcaaaaugcccccguaacuucgggagaagggggacccacauggcguguaagccuuuacggcccaagcgugaguggguggcacaaaccagugagaagcgacuguuuacuaaaaacacagguccgugcgaagucgcaagacgauguauacggacugacgccugcccggugcuggaagguuaagaggacccguuaacucccuuugggggugaagcggagaauuuaagccccaguaaacggcggugguaacuauaaccauccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaacgacuucucaacugucucaaccauagacucggcgaaauugcacuacgaguaaagaugcucguuacgcgcggcaggacgaaaagaccccgggaccuucacuacaacuugguauuggugcucgauacgguuuguguaggauaggugggagacugugaagcucacacgccaguguggguggagucguuguugaaauaccacucugaucguauugggccucuaaccucggaccguauauccgguucagggacagugccugguggguaguuuaacuggggcgguugccuccuaaaauguaacggaggcgcccaaagguucccucaaccuggacggcaaucagguguugaguguaagugcacaagggagcuugacugcgagacggacaugucgagcagggacgaaagucgggacuagugauccggcaccucugaguggaaggggugucgcucaacggauaaaagguaccccggggauaacaggcugaucuuccccaagaguccauaucgacgggaugguuuggcaccucgaugucggcucgucgcauccuggggcuggagcaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguuuagaacgucgugagacaguucggucucuauccgccgcgcgcgucagaagcuugaggaaaccugucccuaguacgagaggaccgggacggacgaaccucugguauaccaguugucccaccaggggcacggcuggauagccacguucggacaggauaaccgcugaaagcaucuaagcgggaaaccucuuccaagaccaggcuucucacccucuaggagggauaaggccccccgcagaccacgggauugauagaccagaccuggaagccuaguaauaggugcagggaacuggcacuaaccggccgaaaacuuac 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((((......((((((((((.....(((..(((((((((((((......((((((.[[.[[[.))).....((((((...(((]]]..]].)))......))))))...)))....(((....)))(((((((......))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))....((([...(((.(..((..........[[[[[......))..).)))....(.((((..(...(.(((.((.]]]]]..)).))).(((((.......((((((.((((.(((...(.((((......)))))[[(...).(((.....]])))...)))...)))))))))))))))..)...)...))))]....(((((((...[.......)))))))....).(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((..(((((((((..)))).)))))..)))).<.(.(........).).((((((....(((.((((((((((..(((...(((....)))...)))...((....))..((((.....))))....(((((((....)))))))....)))))))))))))..((.(...((((((.....((((((((((.((((....(((((......)))))....)[)))...(((.(((((.......A))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([.((((((((.....(((....(((.((((....((.(((....))).).)....)))).)))..)).).....))))))))....).]))))))).))..((((((((((......)))))).))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.((([.(((.........)))..))).....(]..((......)).).)))))...)))))))))).))...........]]].)....))))))))))...)))))))((((((((..))))))))....))))))(.((((((((((......((((((((....))).)))))...))))))))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]]((((((((((.(.....(((...(....(.(......((..(.....((..((...((.(..(......)..).))..)..).).)...)...))......))....).....))).((...(((((...((((..(((..((((..(((((....{{....))))).((..(((....(((((.((((..((.....)).)))).).....))))..[.)))...))...(((......))).....))))...)))...))))(..)....)))))..))..).)))))))))))))).))).....((......)).))))..(((.....)))...))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((...((((....((((..)])))....))))..))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((....((((..((.(((...))).))...))))....))...))))))))..)))))((.(((....)...)).))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....))[[..(((((.....>]])))))..((((((((.(((.((......((((((((((..(((((.((..(((((.((.((.((((((((..............(.((..(.(......(.....((....)).....)...).)............))..)....)))))))).)).))...(((.((((((......)))))))))....)))))..))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.(.((((...((.......))...)))).)...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..a.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..(((((...)))))....((((.((((.......)))).....(((.((((.(((....(((((....)))))...)))..))))..)))...))))....)))).. Mycobacterium smegmatis 50S ribosomal subunit from Log Phase of growth; 23S ribosomal RNA 7y41 B 118 4.1 RF00001 URS00000ACC0A_246196 37709237 0003735 0005840 246196 guuacggcgguccauagcggcagggaaacgcccggucccaucccgaacccggaagcuaagccugccagcgccgaugauacuacccauccggguggaaaaguaggacaccgccgaacac <<<.<<<<<<<.....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<.......<<<<<<....>>>>>>.......>>..>>>>>>>>>>.. (((.(((((((.....((((((((.....((((((...(.....)...))))..))....)))))).)).((.......((((((....)))))).......))..)))))))))).. Mycobacterium smegmatis 50S ribosomal subunit from Log Phase of growth; 5S ribosomal RNA 7y7c A 1520 2.51 RF00177,RF01959,RF02542,RF01960 URS00000ABFE9_562 37992713 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugccggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<........>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<.>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<..>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>.............>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((............))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((.(....).))))......)).).....(((....)))....((((((.)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((((())))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))....(.....)..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Structure of the Bacterial Ribosome with human tRNA Asp(G34) and mRNA(GAU); 16S rRNA 7y7c a 2753 2.51 RF02541 URS00004B0F34_562 37992713 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagcgucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcgcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<..>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<..>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<..>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((..(((.....)))...))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(..)...)))..))))).))...........]]].)...))))))))))...)))))))((((((((()))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((())))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Structure of the Bacterial Ribosome with human tRNA Asp(G34) and mRNA(GAU); 23S rRNA 7y7c b 119 2.51 RF00001 URS0000049E57_562 37992713 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>> ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))) Structure of the Bacterial Ribosome with human tRNA Asp(G34) and mRNA(GAU); 5S rRNA 7y7c X 13 2.51 37992713 562 gcuauggauaaac ............. ............. Structure of the Bacterial Ribosome with human tRNA Asp(G34) and mRNA(GAU); mRNA 7y7c Z 77 2.51 RF00005 URS00001BBAFC_562 37992713 0030533 0006412 562 cgcggggnggagcagccuggnagcucgucgggnucauaacccgaagaucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Structure of the Bacterial Ribosome with human tRNA Asp(G34) and mRNA(GAU); P-site tRNA-fMet 7y7c V 75 2.51 RF00005 URS0002915684_9606 37992713 0030533 0006412 9606 uccucnuunguauaguggngaguauccccgccugucangcgggagannggggnucgnuuccccgacggggagcca <<<<<<<..<<<<........>>>><<<<<<.......>>>>>.>..<<<<<.......>>>>>>>>>>>>.... (((((((..(((.....[....))).(((((.......)))))....(((((..]....)))))))))))).... Structure of the Bacterial Ribosome with human tRNA Asp(G34) and mRNA(GAU); A-site tRNA-Asp 7y7d A 1520 2.58 RF00177,RF01959,RF02542,RF01960 URS00000ABFE9_562 37992713 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugccggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<......>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<.>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<..>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>.............>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((............))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((.)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....(((.((((.......)))).))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((((())))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))....(.....)..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Structure of the Bacterial Ribosome with human tRNA Asp(Q34) and mRNA(GAU); 16S rRNA 7y7d a 2753 2.58 RF02541 URS00004B0F34_562 37992713 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagcgucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcgcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<..>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<..>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<..<<....>>...>>>>>..>....>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<..>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((.(((.....))).).))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(..)...)))..))))).))...........]]].)...))))))))))...)))))))((((((((()))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((())))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Structure of the Bacterial Ribosome with human tRNA Asp(Q34) and mRNA(GAU); 23S rRNA 7y7d b 119 2.58 RF00001 URS0000049E57_562 37992713 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>> ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))) Structure of the Bacterial Ribosome with human tRNA Asp(Q34) and mRNA(GAU); 5S rRNA 7y7d X 13 2.58 37992713 562 gcuauggauaaac ............. ............. Structure of the Bacterial Ribosome with human tRNA Asp(Q34) and mRNA(GAU); mRNA 7y7d Z 77 2.58 RF00005 URS00001BBAFC_562 37992713 0030533 0006412 562 cgcggggnggagcagccuggnagcucgucgggnucauaacccgaagaucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Structure of the Bacterial Ribosome with human tRNA Asp(Q34) and mRNA(GAU); P-site tRNA-fMet 7y7d V 75 2.58 RF00005 URS00029156D4_9606 37992713 0030533 9606 uccucnuunguauaguggngaguauccccgccunucangcgggagannggggnucgnuuccccgacggggagcca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>....<<<<<.......>>>>>>>>>>>>.... (((((((..(((.....[....))).(((((.......)))))....(((((..]....)))))))))))).... Structure of the Bacterial Ribosome with human tRNA Asp(Q34) and mRNA(GAU); A-site tRNA-Asp 7y7e A 1520 2.41 RF00177,RF01959,RF02542,RF01960 URS00000ABFE9_562 37992713 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugccggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<......>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<.>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<..>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>.............>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((.((............))..)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....(((.((.)).))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((((())))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))....(.....)..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Structure of the Bacterial Ribosome with human tRNA Asp(ManQ34) and mRNA(GAU); 16S rRNA 7y7e a 2753 2.41 RF02541 URS00004B0F34_562 37992713 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagcgucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcgcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<..>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<..>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<<.<<....>>..>>>>>>..>....>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<..>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((.(((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))))))).)))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((.((((.....))))..))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(())...)))..))))).))...........]]].)...))))))))))...)))))))((((((((()))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((())))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Structure of the Bacterial Ribosome with human tRNA Asp(ManQ34) and mRNA(GAU); 23S rRNA 7y7e b 119 2.41 RF00001 URS0000049E57_562 37992713 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>> ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))) Structure of the Bacterial Ribosome with human tRNA Asp(ManQ34) and mRNA(GAU); 5S rRNA 7y7e X 13 2.41 37992713 562 gcuauggauaaac ............. ............. Structure of the Bacterial Ribosome with human tRNA Asp(ManQ34) and mRNA(GAU); mRNA 7y7e Z 77 2.41 RF00005 URS00001BBAFC_562 37992713 0030533 0006412 562 cgcggggnggagcagccuggnagcucgucgggnucauaacccgaagaucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Structure of the Bacterial Ribosome with human tRNA Asp(ManQ34) and mRNA(GAU); P-site tRNA-fMet 7y7e V 75 2.41 RF00005 URS00029156D4_9606 37992713 0030533 9606 uccucnuunguauaguggngaguauccccgccunucangcgggagannggggnucgnuuccccgacggggagcca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>....<<<<<.......>>>>>>>>>>>>.... (((((((..(((.....[....))).(((((.......)))))....(((((..]....)))))))))))).... Structure of the Bacterial Ribosome with human tRNA Asp(ManQ34) and mRNA(GAU); A-site tRNA-Asp 7y7f A 1520 2.43 RF00177,RF01959,RF02542,RF01960 URS00000ABFE9_562 37992713 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugccggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<......>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<.>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<..>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((.((............))..)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((.)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(..(.((((((((.......)))))))).)...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((((())))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...((((((....)))))).....(.....)..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Structure of the Bacterial Ribosome with human tRNA Asp(ManQ34) and mRNA(GAC); 16S rRNA 7y7f a 2753 2.43 RF02541 URS00004B0F34_562 37992713 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagcgucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcgcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<..>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<..>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<<.<<....>>..>>>>>>..>....>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<..>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((.((((.....))))..))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(..)...)))..))))).))...........]]].)...))))))))))...)))))))((((((((()))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((())))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Structure of the Bacterial Ribosome with human tRNA Asp(ManQ34) and mRNA(GAC); 23S rRNA 7y7f b 119 2.43 RF00001 URS0000049E57_562 37992713 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>> ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))) Structure of the Bacterial Ribosome with human tRNA Asp(ManQ34) and mRNA(GAC); 5S rRNA 7y7f X 13 2.43 37992713 562 gcuauggacaaac ............. ............. Structure of the Bacterial Ribosome with human tRNA Asp(ManQ34) and mRNA(GAC); mRNA 7y7f Z 77 2.43 RF00005 URS00001BBAFC_562 37992713 0030533 0006412 562 cgcggggnggagcagccuggnagcucgucgggnucauaacccgaagaucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Structure of the Bacterial Ribosome with human tRNA Asp(ManQ34) and mRNA(GAC); P-site tRNA-fMet 7y7f V 75 2.43 RF00005 URS00029156D4_9606 37992713 0030533 9606 uccucnuunguauaguggngaguauccccgccunucangcgggagannggggnucgnuuccccgacggggagcca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>....<<<<<.......>>>>>>>>>>>>.... (((((((..(((.....[....))).(((((.......)))))....(((((..]....)))))))))))).... Structure of the Bacterial Ribosome with human tRNA Asp(ManQ34) and mRNA(GAC); A-site tRNA-Asp 7y7g A 1520 2.34 RF00177,RF01959,RF02542,RF01960 URS00000ABFE9_562 37992713 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugccggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<......>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<.>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<..>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((.(((((......)))))..)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((.)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((((())))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((.(((....))).))).............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Structure of the Bacterial Ribosome with human tRNA Tyr(GalQ34) and mRNA(UAU); 16S rRNA 7y7g a 2753 2.34 RF02541 URS00004B0F34_562 37992713 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagcgucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcgcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<..>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<..>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<<.<<....>>..>>>>>>..>....>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<..>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((.(((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))))))).)))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((.((((.....))))..))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{........)))..))))).))...........]]].)...))))))))))...)))))))((((((((()))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((())))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Structure of the Bacterial Ribosome with human tRNA Tyr(GalQ34) and mRNA(UAU); 23S rRNA 7y7g b 119 2.34 RF00001 URS0000049E57_562 37992713 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>> ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))) Structure of the Bacterial Ribosome with human tRNA Tyr(GalQ34) and mRNA(UAU); 5S rRNA 7y7g X 13 2.34 37992713 562 gcuauguauaaac ............. ............. Structure of the Bacterial Ribosome with human tRNA Tyr(GalQ34) and mRNA(UAU); mRNA 7y7g Z 77 2.34 RF00005 URS00001BBAFC_562 37992713 0030533 0006412 562 cgcggggnggagcagccuggnagcucgucgggnucauaacccgaagaucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Structure of the Bacterial Ribosome with human tRNA Tyr(GalQ34) and mRNA(UAU); P-site tRNA-fMet 7y7g V 76 2.34 URS00029156DE_9606 37992713 9606 ccuucnauancucagnnggnagagcnnaggacunuananccuuagnnngcuggnucgnuuccggcucgaaggacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((.........)))).....(((((..]....)))))))))))).... Structure of the Bacterial Ribosome with human tRNA Tyr(GalQ34) and mRNA(UAU); A-site tRNA-Tyr 7y7h A 1520 2.51 RF00177,RF01959,RF02542,RF01960 URS00000ABFE9_562 37992713 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugccggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<......>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<.>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<..>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((((((......)))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((.(....).))))......)).).....(((....)))....((((((.)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((((())))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....))))))).............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Structure of the Bacterial Ribosome with human tRNA Tyr(GalQ34) and mRNA(UAC); 16S rRNA 7y7h a 2753 2.51 RF02541 URS00004B0F34_562 37992713 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagcgucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcgcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<<..>>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<..>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<..>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<<.<<....>>..>>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<..>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((.(((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))))))).)))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((.((((.....))))..))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{........)))..))))).))...........]]].)...))))))))))...)))))))((((((((()))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((())))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Structure of the Bacterial Ribosome with human tRNA Tyr(GalQ34) and mRNA(UAC); 23S rRNA 7y7h b 119 2.51 RF00001 URS0000049E57_562 37992713 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>> ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))) Structure of the Bacterial Ribosome with human tRNA Tyr(GalQ34) and mRNA(UAC); 5S rRNA 7y7h X 13 2.51 37992713 562 gcuauguacaaac ............. ............. Structure of the Bacterial Ribosome with human tRNA Tyr(GalQ34) and mRNA(UAC); mRNA 7y7h Z 77 2.51 RF00005 URS00001BBAFC_562 37992713 0030533 0006412 562 cgcggggnggagcagccuggnagcucgucgggnucauaacccgaagaucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Structure of the Bacterial Ribosome with human tRNA Tyr(GalQ34) and mRNA(UAC); P-site tRNA-fMet 7y7h V 76 2.51 URS00029156DE_9606 37992713 9606 ccuucnauancucagnnggnagagcnnaggacunuananccuuagnnngcuggnucgnuuccggcucgaaggacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((.........)))).....((.((..]....)).))))))))).... Structure of the Bacterial Ribosome with human tRNA Tyr(GalQ34) and mRNA(UAC); A-site tRNA-Tyr 7y7p C 11 2.7 URS000261773A_32630 36039765 32630 cuauggucgga ........... ........... QDE-1 in complex with RNA template, RNA primer and AMPNPP; RNA (5'-R(*GP*AP*A*CP*UP*AP*UP*GP*GP*UP*CP*GP*GP*A)-3') 7y7p E 11 2.7 URS000261773A_32630 36039765 32630 cuauggucgga ........... ........... QDE-1 in complex with RNA template, RNA primer and AMPNPP; RNA (5'-R(*GP*AP*A*CP*UP*AP*UP*GP*GP*UP*CP*GP*GP*A)-3') 7y7q C 10 2.05 URS000261773F_32630 36039765 32630 uaccgucgga .......... .......... QDE-1 in complex with RNA template, RNA primer and 3'-dGTP; RNA (5'-R(*GP*AP*AP*CP*UP*AP*CP*CP*GP*UP*CP*GP*GP*A)-3') 7y81 B 36 2.54 URS00026177AC_237368 36477448 237368 gacuuaaugucacgguacccaauuuucugccccgga .................................... .................................... CryoEM structure of type III-E CRISPR Craspase gRAMP-crRNA complex bound to non-self RNA target; crRNA 7y81 C 19 2.54 URS00026177AA_237368 36477448 237368 uccggggcagaaaauuggc ................... ................... CryoEM structure of type III-E CRISPR Craspase gRAMP-crRNA complex bound to non-self RNA target; Non-self RNA target 7y82 B 41 2.83 URS00026177AC_237368 36477448 237368 gacuuaaugucacgguacccaauuuucugccccggacucca ......................................... ......................................... CryoEM structure of type III-E CRISPR Craspase gRAMP-crRNA complex bound to self RNA target; crRNA 7y82 C 25 2.83 URS00026177AB_237368 36477448 237368 uggaguccggggcagaaaauugggu ......................... ......................... CryoEM structure of type III-E CRISPR Craspase gRAMP-crRNA complex bound to self RNA target; Self RNA target 7y83 B 36 2.93 URS00026177AC_237368 36477448 237368 gacuuaaugucacgguacccaauuuucugccccgga .................................... .................................... CryoEM structure of type III-E CRISPR Craspase gRAMP-crRNA in complex with TPR-CHAT protease bound to non-self RNA target; crRNA 7y83 C 23 2.93 URS00026177AA_237368 36477448 237368 uccggggcagaaaauuggcaugg ....................... ....................... CryoEM structure of type III-E CRISPR Craspase gRAMP-crRNA in complex with TPR-CHAT protease bound to non-self RNA target; non-self RNA 7y85 B 36 2.73 URS00026177AC_237368 36477448 237368 gacuuaaugucacgguacccaauuuucugccccgga .................................... .................................... CryoEM structure of type III-E CRISPR Craspase gRAMP-crRNA in complex with TPR-CHAT protease bound to self RNA target; crRNA 7y85 C 23 2.73 URS00026177AB_237368 36477448 237368 uccggggcagaaaauuggguacc ....................... ....................... CryoEM structure of type III-E CRISPR Craspase gRAMP-crRNA in complex with TPR-CHAT protease bound to self RNA target; Self RNA target 7y8p A 12 1.5 URS00026813F9_32630 36434923 32630 ggannngagucc ............ ............ Crystal structure of 4'-selenoRNA duplex; RNA (5'-R(*GP*GP*AP*(IKS)P*(ILK)P*(IKS)P*GP*AP*GP*UP*CP*C)-3') 7y8p B 12 1.5 URS00026813F9_32630 36434923 32630 ggannngagucc ............ ............ Crystal structure of 4'-selenoRNA duplex; RNA (5'-R(*GP*GP*AP*(IKS)P*(ILK)P*(IKS)P*GP*AP*GP*UP*CP*C)-3') 7y8y D 37 3.0 URS0002681432_237368 36280712 237368 ggacuuaaugucacgguacccaauuuucugccccgga ..................................... ..................................... Structure of Cas7-11-crRNA-tgRNA in complex with TPR-CHAT; RNA (37-MER) 7y8y E 18 3.0 URS0002681441_237368 36280712 237368 cggggcagaaaauuggac .................. .................. Structure of Cas7-11-crRNA-tgRNA in complex with TPR-CHAT; RNA (5'-R(P*CP*GP*GP*GP*GP*CP*AP*GP*AP*AP*AP*AP*UP*UP*GP*GP*AP*C)-3') 7y9y R 38 2.77 URS0002617753_45657 36423304 45657 uugaugucacggaaccuuuguugucuucgacaugggua ...................................... ...................................... Structure of the Cas7-11-Csx29-guide RNA-target RNA (no PFS) complex; RNA (38-MER) 7y9y D 23 2.77 URS0002617771_45657 36423304 45657 uacccaugucgaagacaacaaag ....................... ....................... Structure of the Cas7-11-Csx29-guide RNA-target RNA (no PFS) complex; RNA (27-MER) 7ycg B 11 3.18 URS0002681436_5890 36660826 5890 cccucuaaacc ........... ........... Cryo-EM structure of Tetrahymena ribozyme conformation 2 undergoing the first-step self-splicing; RNA (5'-R(*CP*CP*CP*UP*CP*UP*AP*AP*AP*CP*C)-3') 7ycg N 393 3.18 RF00028 URS00026813C7_5890 36660826 0000372 5890 gguuuggagggaaaaguuaucaggcaugcaccugguagcuagucuuuaaaccaauagauugcaucgguuuaaaaggcaagaccgucaaauugcgggaaaggggucaacagccguucaguaccaagucucaggggaaacuuugagauggccuugcaaaggguaugguaauaagcugacggacaugguccuaaccacgcagccaaguccuaagucaacagaucuucuguugauauggaugcaguucacagacuaaaugucggucggggaagauguauucuucucauaagauauagucggaccucuccuuaaugggagcuagcggaugaagugaugcaacacuggagccgcugggaacuaauuuguaugcgaaaguauauugauuaguuuuggagu ..............<<<<<<<<<<..(((.>>>>>>>>>>.<<<<<<<<<<<......<<<<<<.>>>>>>.>>>>>..<<<<<.<....<<<<<<...<<<<<<.....<<<.<<<<.<<...<<<<<<<<<....>>>>>>>>>..<<..)))..>>.....>>......>>>>>>>....>>>>>>..>>.>>>><<...<<<<...<<<<<<<<<...>>>>>>>>>..>>>>...>>.....(((((...>.>>>>>.<<<<<<<.....>>>>>>>........)))))...(..<<<<<....>>>>><<<<<<<....<<<<>>>>>>>>>>....>>>>>>>.<<<<<<<<.<<<<<......>>>>>.>>>>>>>>..).... ..............((((((((((..{{{.)))))))))).(((((((((((......[[[[[[.)))))).)))))..(((((.(....((((((...((((((.....(((.((((.(((..((((((.((....)).))))))..((..}}.}.))....)))......)))))))....))))))..)).))))((...((((..((((((((((...))))))))).)))))...))...[.[[[[[...).))))).(((((((.....)))))))........]]]]]]..((.(((((....)))))(((((((....((((]]]]]]))))....))))))).((((((((..(((.(....).)))..))))))))..))... Cryo-EM structure of Tetrahymena ribozyme conformation 2 undergoing the first-step self-splicing; RNA (393-MER) 7ych B 11 3.09 URS0002681436_5890 36660826 5890 cccucuaaacc ........... ........... Cryo-EM structure of Tetrahymena ribozyme conformation 3 undergoing the first-step self-splicing; RNA (5'-R(*CP*CP*CP*UP*CP*UP*AP*AP*AP*CP*C)-3') 7ych N 393 3.09 RF00028 URS00026813C7_5890 36660826 0000372 5890 gguuuggagggaaaaguuaucaggcaugcaccugguagcuagucuuuaaaccaauagauugcaucgguuuaaaaggcaagaccgucaaauugcgggaaaggggucaacagccguucaguaccaagucucaggggaaacuuugagauggccuugcaaaggguaugguaauaagcugacggacaugguccuaaccacgcagccaaguccuaagucaacagaucuucuguugauauggaugcaguucacagacuaaaugucggucggggaagauguauucuucucauaagauauagucggaccucuccuuaaugggagcuagcggaugaagugaugcaacacuggagccgcugggaacuaauuuguaugcgaaaguauauugauuaguuuuggagu ..............<<<<<<<<<<..(((.>>>>>>>>>>.<<<<<<<<<<<......<<<<<<.>>>>>>.>>>>>..<<<<<.<....<<<<<<...<<<<<<.....<<<.<<<<.<<...<<<<<<<<......>>>>>>>>..<<..)))..>>.....>>......>>>>>>>....>>>>>>..>>.>>>><<...<<<<...<<<<<<<<<...>>>>>>>>>..>>>>...>>.....(((((...>.>>>>>.<<<<<<<.....>>>>>>>........)))))...((.<<<<<....>>>>><<<<<<<....<<<<>>>>>>>>>>....>>>>>>>.<<<<<<<<.<<<<<......>>>>>.>>>>>>>>..))... ..............((((((((((..{{{.)))))))))).(((((((((((......[[[[[[.)))))).)))))..(((((.(....((((((...((((((.....(((.((((.(((..((((((.((....)).))))))..((..}}.}.))....)))......)))))))....))))))..)).)))).(...((((..((((((((((...))))))))).)))))...)....[.[[[[[...).))))).(((((((.....)))))))........]]]]]]..((.(((((....)))))(((((((....((((]]]]]]))))....))))))).((((((((..(((.(....).)))..))))))))..))... Cryo-EM structure of Tetrahymena ribozyme conformation 3 undergoing the first-step self-splicing; RNA (393-MER) 7yci N 389 2.98 RF00028 URS00026813C7_5890 36660826 0000372 5890 uggagggaaaaguuaucaggcaugcaccugguagcuagucuuuaaaccaauagauugcaucgguuuaaaaggcaagaccgucaaauugcgggaaaggggucaacagccguucaguaccaagucucaggggaaacuuugagauggccuugcaaaggguaugguaauaagcugacggacaugguccuaaccacgcagccaaguccuaagucaacagaucuucuguugauauggaugcaguucacagacuaaaugucggucggggaagauguauucuucucauaagauauagucggaccucuccuuaaugggagcuagcggaugaagugaugcaacacuggagccgcugggaacuaauuuguaugcgaaaguauauugauuaguuuuggagu ..........<<<<<<<<<<..(((.>>>>>>>>>>.<<<<<<<<<<<......<<<<<<.>>>>>>.>>>>>..<<<<<.<....<<<<<<...<<<<<<.....<<<.<<<<.<<...<<<<<<<<......>>>>>>>>..<<..)))..>>.....>>......>>>>>>>....>>>>>>..>>.>>>><<...<<<<...<<<<<<<<<...>>>>>>>>>..>>>>...>>.....(((((...>.>>>>>.<<<<<<<.....>>>>>>>........)))))...(..<<<<<....>>>>><<<<<<<....<<<<>>>>>>>>>>....>>>>>>>.<<<<<<<<.<<<<<......>>>>>.>>>>>>>>...)... ..........((((((((((..{{{.)))))))))).(((((((((((......[[[[[[.)))))).)))))..(((((.(....((((((...((((((.....(((.((((.(((..((((((.((....)).))))))..((..}}.}.))....)))......)))))))....))))))..)).)))).(...((((..((((((((((...))))))))).)))))...)....[.[[[[[...).))))).(((((((.....)))))))........]]]]]]..((.(((((....)))))(((((((....((((]]]]]]))))....))))))).(((((((...(((.(....).)))...)))))))..))... Cryo-EM structure of Tetrahymena ribozyme conformation 4 undergoing the first-step self-splicing; RNA (389-MER) 7yed M 21 3.0 URS00026813DE_538123 36469786 538123 uuuaaaaauuuuaaaauaauu ..................... ..................... In situ structure of polymerase complex of mammalian reovirus in the elongation state; RNA (5'-R(P*UP*UP*UP*AP*AP*AP*AP*AP*UP*UP*UP*UP*AP*AP*AP*AP*UP*AP*AP*UP*U)-3') 7yed N 26 3.0 URS00026813DF_538123 36469786 538123 auauauauauauuaauauauauauau .......................... .......................... In situ structure of polymerase complex of mammalian reovirus in the elongation state; RNA (36-MER) 7yed T 36 3.0 URS00026813E2_538123 36469786 538123 auauauauauauaaaauuauuuuaauauauauauau .................................... .................................... In situ structure of polymerase complex of mammalian reovirus in the elongation state; RNA (36-MER) 7yfq B 25 3.2 URS00029156CE_9606 38658622 9606 uuaccaucaacauggaaacuuggcn ......................... ......................... Cryo-EM structure of the EfPiwi (N959K)-piRNA-target ternary complex; piRNA 7yfq C 16 3.2 URS00029156CF_9606 38658622 9606 uccauguugaugguaa ................ ................ Cryo-EM structure of the EfPiwi (N959K)-piRNA-target ternary complex; RNA (5'-R(*UP*CP*CP*AP*UP*GP*UP*UP*GP*AP*UP*GP*GP*UP*AP*A)-3') 7yfy C 15 3.4 URS00029156C8_9606 38658622 9606 ccauguugaugguaa ............... ............... Cryo-EM structure of the Mili-piRNA- target ternary complex; RNA (5'-R(P*CP*CP*AP*UP*GP*UP*UP*GP*AP*UP*GP*GP*UP*AP*A)-3') 7yfy B 26 3.4 URS0000400A3F_9606 38658622 9606 uuaccaucaacauggaaacuuggcun .......................... .......................... Cryo-EM structure of the Mili-piRNA- target ternary complex; piRNA 7yg8 N 387 2.97 RF00028 URS00026813C7_5890 36928031 0000372 5890 gagggaaaaguuaucaggcaugcaccugguagcuagucuuuaaaccaauagauugcaucgguuuaaaaggcaagaccgucaaauugcgggaaaggggucaacagccguucaguaccaagucucaggggaaacuuugagauggccuugcaaaggguaugguaauaagcugacggacaugguccuaaccacgcagccaaguccuaagucaacagaucuucuguugauauggaugcaguucacagacuaaaugucggucggggaagauguauucuucucauaagauauagucggaccucuccuuaaugggagcuagcggaugaagugaugcaacacuggagccgcugggaacuaauuuguaugcgaaaguauauugauuaguuuuggagu ........<<<<<<<<<<..(((.>>>>>>>>>>.<<<<<<<<<<<......<<<<<<.>>>>>>.>>>>>..<<<<<.<....<<<<<<...<<<<<<.....<<<.<<<<.<<...<<<<<<<<<....>>>>>>>>>..<<..)))..>>.....>>......>>>>>>>....>>>>>>..>>.>>>><<...<<<<...<<<<<<<<<...>>>>>>>>>..>>>>...>>.....(((((...>.>>>>>.<<<<<<<.....>>>>>>>........)))))...(..<<<<<....>>>>><<<<<<<....<<<<>>>>>>>>>>....>>>>>>>.<<<<<<<<.<<<<<......>>>>>.>>>>>>>>..).... ........((((((((((..{{{.)))))))))).(((((((((((......[[[[[[.)))))).)))))..(((((.(....((((((...((((((.....(((.((((.(((..(((((((((....)))))))))..((..}}.}.))....)))......)))))))....))))))..)).))))((...((((..((((((((((...))))))))).)))))...))...[.[[[[[...).))))).(((((((.....)))))))........]]]]]]..(..((((......))))(((((((....((((]]]]]]))))....))))))).(((((((...(((.(....).)))...)))))))..).... Cryo-EM structure of Tetrahymena ribozyme conformation 5 undergoing the second-step self-splicing; RNA (387-MER) 7yg9 N 391 2.68 RF00028 URS00026813C7_5890 36928031 0000372 5890 uuuggagggaaaaguuaucaggcaugcaccugguagcuagucuuuaaaccaauagauugcaucgguuuaaaaggcaagaccgucaaauugcgggaaaggggucaacagccguucaguaccaagucucaggggaaacuuugagauggccuugcaaaggguaugguaauaagcugacggacaugguccuaaccacgcagccaaguccuaagucaacagaucuucuguugauauggaugcaguucacagacuaaaugucggucggggaagauguauucuucucauaagauauagucggaccucuccuuaaugggagcuagcggaugaagugaugcaacacuggagccgcugggaacuaauuuguaugcgaaaguauauugauuaguuuuggagu ............<<<<<<<<<<..(((.>>>>>>>>>>.<<<<<<<<<<<......<<<<<<.>>>>>.>>>>>>..<<<<<.<....<<<<<<...<<<<<<.....<<<.<<<<.<<...<<<<<<<<<....>>>>>>>>>..<<..)))..>>.....>>......>>>>>>>....>>>>>>..>>.>>>><<...<<<<...<<<<<<<<<...>>>>>>>>>..>>>>...>>.....(((((...>.>>>>>.<<<<<<<.....>>>>>>>........)))))...(..<<<<<....>>>>><<<<<<<....<<<<>>>>>>>>>>....>>>>>>>.<<<<<<<<.<<<<<......>>>>>.>>>>>>>>..).... ............((((((((((..{{{.)))))))))).(((((((((((....(.[[[[[[))))))).)))))..(((((.(....((((((...((((((.....(((.((((.(((..(((((((((....)))))))))..((..}}.}.))....)))......)))))))....))))))..)).))))((...((((..((((((((((...))))))))).)))))...))...[.[[[[[...).))))).(((((((.....)))))))........]]]]]]..(..(((((....)))))(((((((.....(((]]]]]]))).....))))))).((((((((..(((.(....).)))..))))))))..).... Cryo-EM structure of Tetrahymena ribozyme conformation 1 undergoing the second-step self-splicing; RNA (391-MER) 7yga N 393 2.35 RF00028 URS00026813C7_5890 36928031 0000372 5890 gguuuggagggaaaaguuaucaggcaugcaccugguagcuagucuuuaaaccaauagauugcaucgguuuaaaaggcaagaccgucaaauugcgggaaaggggucaacagccguucaguaccaagucucaggggaaacuuugagauggccuugcaaaggguaugguaauaagcugacggacaugguccuaaccacgcagccaaguccuaagucaacagaucuucuguugauauggaugcaguucacagacuaaaugucggucggggaagauguauucuucucauaagauauagucggaccucuccuuaaugggagcuagcggaugaagugaugcaacacuggagccgcugggaacuaauuuguaugcgaaaguauauugauuaguuuuggagu ..............<<<<<<<<<<..(((.>>>>>>>>>>.<<<<<<<<<<<......<<<<<<.>>>>>.>>>>>>..<<<<<.<....<<<<<<...<<<<<<.....<<<.<<<<.<<...<<<<<<<<<....>>>>>>>>>..<<..)))..>>.....>>......>>>>>>>....>>>>>>..>>.>>>><<...<<<<...<<<<<<<<<...>>>>>>>>>..>>>>...>>.....(((((...>.>>>>>.<<<<<<<.....>>>>>>>........)))))...(..<<<<<....>>>>><<<<<<<....<<<<>>>>>>>>>>....>>>>>>>.<<<<<<<<.<<<<<......>>>>>.>>>>>>>>..).... ..............((((((((((..{{{.)))))))))).(((((((((((....(.[[[[[[))))))).)))))..(((((.(....((((((...((((((.....(((.((((.(((..(((((((((....)))))))))..((..}}.}.))....)))......)))))))....))))))..)).))))((...((((..((((((((((...))))))))).)))))...))...[.[[[[[...).))))).(((((((.....)))))))........]]]]]]..(..(((((....)))))(((((((....((((]]]]]]))))....))))))).(((((((..((((.(....).))))..)))))))..).... Cryo-EM structure of Tetrahymena ribozyme conformation 2 undergoing the second-step self-splicing; RNA (393-MER) 7ygb B 11 2.62 URS00026813CD_5890 36928031 5890 cccucunaacc ........... ........... Cryo-EM structure of Tetrahymena ribozyme conformation 3 undergoing the second-step self-splicing; RNA (5'-R(*CP*CP*CP*UP*CP*UP*UP*AP*AP*CP*C)-3') 7ygb N 393 2.62 RF00028 URS00026813C7_5890 36928031 0000372 5890 gguuuggagggaaaaguuaucaggcaugcaccugguagcuagucuuuaaaccaauagauugcaucgguuuaaaaggcaagaccgucaaauugcgggaaaggggucaacagccguucaguaccaagucucaggggaaacuuugagauggccuugcaaaggguaugguaauaagcugacggacaugguccuaaccacgcagccaaguccuaagucaacagaucuucuguugauauggaugcaguucacagacuaaaugucggucggggaagauguauucuucucauaagauauagucggaccucuccuuaaugggagcuagcggaugaagugaugcaacacuggagccgcugggaacuaauuuguaugcgaaaguauauugauuaguuuuggagu ..............<<<<<<<<<<..(((.>>>>>>>>>>.<<<<<<<<<<<......<<<<<<.>>>>>>.>>>>>..<<<<<.<....<<<<<<...<<<<<<.....<<<.<<<<.<<...<<<<<<<<<....>>>>>>>>>..<<..)))..>>.....>>......>>>>>>>....>>>>>>..>>.>>>><<...<<<<...<<<<<<<<<...>>>>>>>>>..>>>>...>>.....(((((...>.>>>>>.<<<<<<<.....>>>>>>>........)))))...(..<<<<<....>>>>><<<<<<<.(..<<<<>>>>>>>>>>...)>>>>>>>.<<<<<<<<.<<<<<......>>>>>.>>>>>>>>..).... ..............((((((((((..{{{.)))))))))).(((((((((((......[[[[[[.)))))).)))))..(((((.(....((((((...((((((.....(((.((((.(((..(((((((((....)))))))))..((..}}.}.))....)))......)))))))....))))))..)).))))((...((((..((((((((((...))))))))).)))))...))...[.[[[[[...).))))).(((((((.....)))))))........]]]]]]..(..(((((....)))))(((((((....((((]]]]]]))))....))))))).(((((((..((((((....))))))..)))))))..).... Cryo-EM structure of Tetrahymena ribozyme conformation 3 undergoing the second-step self-splicing; RNA (393-MER) 7ygc B 11 2.65 URS00026813CD_5911 36928031 5911 cccucunaacc ........... ........... Cryo-EM structure of Tetrahymena ribozyme conformation 4 undergoing the second-step self-splicing; RNA (5'-R(*CP*CP*CP*UP*CP*UP*UP*AP*AP*CP*C)-3') 7ygc N 393 2.65 RF00028 URS00026813C7_5911 36928031 0000372 5911 gguuuggagggaaaaguuaucaggcaugcaccugguagcuagucuuuaaaccaauagauugcaucgguuuaaaaggcaagaccgucaaauugcgggaaaggggucaacagccguucaguaccaagucucaggggaaacuuugagauggccuugcaaaggguaugguaauaagcugacggacaugguccuaaccacgcagccaaguccuaagucaacagaucuucuguugauauggaugcaguucacagacuaaaugucggucggggaagauguauucuucucauaagauauagucggaccucuccuuaaugggagcuagcggaugaagugaugcaacacuggagccgcugggaacuaauuuguaugcgaaaguauauugauuaguuuuggagu ..............<<<<<<<<<<..(((.>>>>>>>>>>.<<<<<<<<<<<......<<<<<<.>>>>>>.>>>>>..<<<<<.<....<<<<<<...<<<<<<.....<<<.<<<<.<<...<<<<<<<<<....>>>>>>>>>..<<..)))..>>.....>>......>>>>>>>....>>>>>>..>>.>>>><<...<<<<...<<<<<<<<<...>>>>>>>>>..>>>>...>>.....(((((...>.>>>>>.<<<<<<<.....>>>>>>>........)))))...(..<<<<<....>>>>><<<<<<<....<<<<>>>>>>>>>>....>>>>>>>.<<<<<<<<.<<<<<......>>>>>.>>>>>>>>..).... ..............((((((((((..{{{.)))))))))).(((((((((((......[[[[[[.)))))).)))))..(((((.(....((((((...((((((.....(((.((((.(((..(((((((((....)))))))))..((..}}.}.))....)))......)))))))....))))))..)).))))((...((((..((((((((((...))))))))).)))))...))...[.[[[[[...).))))).(((((((.....)))))))........]]]]]]..(..(((((....)))))(((((((....((((]]]]]]))))....))))))).((((((((.((((((....)))))).))))))))..).... Cryo-EM structure of Tetrahymena ribozyme conformation 4 undergoing the second-step self-splicing; RNA (393-MER) 7ygd N 384 3.41 RF00028 URS00026813C7_5890 36928031 0000372 5890 ggaaaaguuaucaggcaugcaccugguagcuagucuuuaaaccaauagauugcaucgguuuaaaaggcaagaccgucaaauugcgggaaaggggucaacagccguucaguaccaagucucaggggaaacuuugagauggccuugcaaaggguaugguaauaagcugacggacaugguccuaaccacgcagccaaguccuaagucaacagaucuucuguugauauggaugcaguucacagacuaaaugucggucggggaagauguauucuucucauaagauauagucggaccucuccuuaaugggagcuagcggaugaagugaugcaacacuggagccgcugggaacuaauuuguaugcgaaaguauauugauuaguuuuggagu .....<<<<<<<<<<..(((.>>>>>>>>>>.<<<<<<<<<<<......<<<<<<.>>>>>>.>>>>>..<<<<<.<....<<<<<<...<<<<<<.....<<<.<<<<.<<...<<<<<<<<<....>>>>>>>>>..<<..)))..>>.....>>......>>>>>>>....>>>>>>..>>.>>>><<...<<<<...<<<<<<<<<...>>>>>>>>>..>>>>...>>.....(((((...>.>>>>>.<<<<<<<.....>>>>>>>........)))))...(..<<<<<....>>>>><<<<<<<....<<<<>>>>>>>>>>....>>>>>>>.<<<<<<<<.<<<<<......>>>>>.>>>>>>>>..).... .....((((((((((..{{{.)))))))))).(((((((((((......[[[[[..)))))).)))))..(((((.(....((((((...((((((.....(((.((((.(((...((((((((....))))))))...((..}}.}.))....)))......)))))))....))))))..)).))))((...((((..((((((((((...))))))))).)))))...))...[.[[[[[...).))))).(.(((((.....))))).)........]]]]]]..(..(((((....)))))(((((((....((((.]]]]]))))....))))))).((((((((..(((.(....).)))..))))))))..).... Cryo-EM structure of Tetrahymena ribozyme conformation 6 undergoing the second-step self-splicing; RNA (384-MER) 7yla I 2876 2.52 RF02541 URS00004B0F34_562 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcugcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaa ..<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<.>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<...<<<<<........>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<.>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<.......>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<.<<....>>.>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<....<<..>>.....>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<<.<<....>>..>>>>>>........>>>>>>>>..>>>>><<<..>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<...<<............<<<<<..<<<......<<<<<.<<....>>.>>>>>...>>>............>>>>>...>>...>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>.(<<...<<<<<<<...<<<<<<.......>>>>>>.....<<)..(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>> ..((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((.......(((.((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))).)))....))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((.))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((........)))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((.(...))..))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{....((.((...(((.....)))...).)....(...((......)).).))......)))..))))).))...........]]].)...))))))))))...)))))))((((((.((....)).))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..(((((.((((((...{{{.).))))).((..((((...(((((.(.((((.((.....)))))).).)..))))..[))))...))(...((((....))))....))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((.(....]).))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((..)))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((.(......(.(............(...(........((..(.((....)).)..)).....).............)...).)......).)))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))) Cryo-EM structure of 50S-HflX complex; Escherichia coli strain K-12 substr. MG1655_TMP32XR1 chromosome, complete genome 7yla J 118 2.52 RF00001 URS0000366A67_562 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))). Cryo-EM structure of 50S-HflX complex; 5S rRNA 7yna B 38 3.64 URS00026813B7_45657 36702942 45657 uugaugucacggaacaggaacuugaacaacaucguuac ...................................... ...................................... Cryo-EM structure of Cas7-11-crRNA bound to target RNA-1; crRNA (38-MER) 7yna C 25 3.64 URS000268138F_45657 36702942 45657 uaguaacgauguuguucaaguuccu ......................... ......................... Cryo-EM structure of Cas7-11-crRNA bound to target RNA-1; Target RNA-1 (25-MER) 7ynb B 38 3.46 URS00026813B7_45657 36702942 45657 uugaugucacggaacaggaacuugaacaacaucguuac ...................................... ...................................... Cryo-EM structure of Cas7-11-crRNA bound to target RNA-2; crRNA (38-MER) 7ynb C 28 3.46 URS00026813A1_45657 36702942 45657 uaguaacgauguuguucaaguuccuguu ............................ ............................ Cryo-EM structure of Cas7-11-crRNA bound to target RNA-2; Target RNA-2 (28-MER) 7ync B 38 3.14 URS00026813B7_45657 36702942 45657 uugaugucacggaacaggaacuugaacaacaucguuac ...................................... ...................................... Cryo-EM structure of Cas7-11-crRNA bound to target RNA-3; crRNA (38-MER) 7ync C 28 3.14 URS0002681393_45657 36702942 45657 uaguaacgauguuguucaaguuccucaa ............................ ............................ Cryo-EM structure of Cas7-11-crRNA bound to target RNA-3; Target RNA-3 (28-MER) 7ypa H 20 3.05 URS0002617764_32630 36631609 32630 gcgucgcaggccuuuuuauu .................... .................... Cryo-EM structure of Escherichia coli hairpin-nucleation complex of transcription termination (TTC-hairpin); RNA (5'-R(*GP*CP*GP*UP*CP*GP*CP*AP*GP*GP*CP*CP*UP*UP*UP*UP*UP*AP*UP*U)-3') 7ypa I 10 3.05 URS0002617786_32630 36631609 32630 ccugcgacgc .......... .......... Cryo-EM structure of Escherichia coli hairpin-nucleation complex of transcription termination (TTC-hairpin); RNA (5'-R(*CP*CP*UP*GP*CP*GP*AP*CP*GP*C)-3') 7z20 a 118 2.29 RF00001 URS0000049E57_562 35869078 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))). 70S E. coli ribosome with an extended uL23 loop from Candidatus marinimicrobia and a stalled filamin domain 5 nascent chain; 5S rRNA 7z20 b 2901 2.29 RF02541 URS0000311517_562 35869078 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaagcgacuugcucguggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuagaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaagggugaugcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaacc <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<<.>>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<................>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<.........<.............>...............<......>.......>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<........>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<<.<<....>>..>>>>>>..>....>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<..................................................................................>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<..<<.....>>..>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>> ((((((((......((((((((((.....(((..(((((((((((((......((((((.[...[[.))).....((((((...(((]]...].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((...))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((...(((((((((.....(((...(((.((((...(((.(.........).).))...)))).)))..)).).....)))))).)))...))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((......(.....{.((......(...(...........)...)..........(.(......).).....))...)......))).))...........]]].)...))))))))))...)))))))(((((((........)))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((..((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((.((..)]).))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.................(.......................................................)........)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..)))....((.....))........)))))..)...))).))....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))) 70S E. coli ribosome with an extended uL23 loop from Candidatus marinimicrobia and a stalled filamin domain 5 nascent chain; 23S rRNA 7z20 v 77 2.29 RF00005 URS00001DEEBE_562 35869078 0030533 0006412 562 cggugauuggcgcagccugguagcgcacuucguucgggacgaaggggucggagguucgaauccucuaucaccgacca <<<<<<<..<<<<.........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (.(((((...(((......[..)))..((((.........)))).....(((((..]....)))))))))).).... 70S E. coli ribosome with an extended uL23 loop from Candidatus marinimicrobia and a stalled filamin domain 5 nascent chain; Pro-tRNA 7z34 1 3347 3.8 RF02543 URS000061F377_559292 36097293 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaugguguuuugugcucgcauuucacugggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaaggguagugagggccuuggucagacgcagcgggcgugcuuguggacugcuugguggggcuugcucugcuaggcggacuacuugcgugccuuguuguagacggccuugguaggucucuuguagaccgucgcuugcuacaaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauagaggguguagaauaagugggagcuucggcgccagugaaauaccacuaccuuuauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<<.<<<<<.<<<<<<.<<<<<<<.....<<<<......>>>>.(.......<<<......)>>>....>>>>>>>...>>>>>>.>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<......<<<<.....<....>.....>>>>..<<<<<<<.<<<<<<<<<<<<<<<.....<<<<.<<<<....<.<<<<<......>>>>>>......>>>>.>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<...<<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>>.<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<..........................<....<.....>...>........................>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><<<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>.>>.....>>>>>><<<....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>.........<<<<<........>>>>>.....>>....>>...<<<<<........>>>>>))<<<<..<<<<<<.....<<<....>>>.....{{<<<<<<...<<<<.<<<<<<<<<<<<<<<<<<..[[[..>>>>>>....<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>.....<<<<<<<......>>>>>>>>>>>.>.>>>>>>>.>>>>.........>>>>>>..........>>>..>>>.>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<....<<..>>.....>>>>><<.<<<<<........<<........<<....<<<<<<<<<<<<<..<<<<.<<<<<.<<<<<<......>>>>>>.>>>>>.>>>>..>>>>>>>.>>>>>>....>>........<<...........>>....>>..........>>>>>.>>.............<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<..<...<<....<<<<<....>>>>.>...>>.>.>>>..>>>>><<<<<...>...>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>......>>.>>>>>>>..>>>>>>...>>>....<<<<<........>>>>>....(((((..[[[........(((((...((((..<<<<<.<<<<<<<<..<<<<.<.<<<<<<<.<............<<<........................>>>...>.>>>>.>>>..>>>>>...<<<<<.....<<<<..<<.<........>.>>..........}}...<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......[[[.....((((.>>>>>>))))...]]]..........))))....)))))...............<<.....................>>..................<<<..<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>......>>>.......<<<<<<<....>>>.>>>>........]]].)))))....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<....<<<<<<<<<<]]].>>>>>..>>>>>...>>>>..>>>>>.<<<<.....<<<...........>>>.....>>>>.>>>>....>>>>>>>>.......<<<<<<...........<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>....................>>>>>>..<<<<<.<..<.......>..>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................((((((.....(...[..)......))))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((..((((..(((((..(((((.(...(.((((......)))))..(...).(((.......)))....).)))))....)))).).....)))).))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))..(......)..).....................(((((.(((((.....(.(((...((.(..).))...)))..)(((((((.(((((((((.(((((.......(...((........(((........))).........))...).....)))))..)))))))))........(((....))).....))))))).....))))).))))).[((((........))))((((((....(.((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).)))).)..((.(...((((((.....(((((((((..(.((...(((((((....)))))))...)[).)....((..((.((.......<)))).)).....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((....((.(((((((............(...............(.((.....)).).............)...........)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))((((((((((.((......((((.((((....))))))))...)))))))))).)).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....))).........(..(((.....).))...)....))....))...(((((........)))))]]((((..(((.(((...((((....)))...(.<.((((((...((((.((((((((((((((((((..{{{..))))))(...((((.....(((((......((.....))......)))))......))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....)))...))).)))).)))..)).....((......)).)))).((((.....))))..))))..(((.(....(((((((.((.......(.......(((((....(.{..).....)))))((.((((((.......((.........(.....((.(.(((..((..((.(.(.((.((((.(.(....).).)))).)).).).))..))..)))..).)).....).........((...........))....).)........)))))).))(...).......(((.(((((.].((.........))...(((((((....(((.......)))......))))))).}.(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(.((........)).).........(..........((((.........))))..).......)))....)).))).))).)...)).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((.....(((((.(((((...((.((..(((((((..((((.(..((((((...(......[...(.(.....................]..).)..)..)))).))...)))))....((((.....((((..((..(.......).))...........>....(.((......)).)...))))..))))......)))))))...)).))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...((..(((((....{..)))).).)).(((....))).))]]].].....(.......((((.]]]]]])))).....)....)}.....)))..)))))))...............((.(...(.........)...).))...................((..(.(((..(..(((((........)))))....).(((.........))).....))).)......))........(((((((....))).))))..>.))..))).)))))....((.(((((..(((..(.(((((......(....).....))))).)((((....(((.....((((((((((}}}.)))))..)))))....)))...)))).((((.....(((....}......))).....))))..)))....))))).)).......((((.............((.(........(((((((..).)))))).....))).......((((((....(....(..(((......)))..)....)..))))))......................))))..(((((....(.......)......(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Structure of pre-60S particle bound to DRG1(AFG2).; 35S pre-ribosomal RNA 7z34 2 121 3.8 RF00001 URS000055688D_559292 36097293 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<<............>>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(.(((..((....)).))).).....))))))))))))))). Structure of pre-60S particle bound to DRG1(AFG2).; 5S rRNA 7z34 3 157 3.8 RF00002 URS00001BF64E_559292 36097293 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>.................... .........................................(.((((.[[.....))).....(.(((....(.]].)............)))..)...).)....((.....))(((((((((....))))))))).................... Structure of pre-60S particle bound to DRG1(AFG2).; 5.8S rRNA 7z3n 1 3191 3.2 RF02543 URS000051B013_759272 37081320 0003735 0005840 759272 guugaccucggaucagguaggaggacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaacagggauugcccuaguaacggcgagugaagcggcaacagcucaaauuugaaagcuggcuucggcccgcguuguaauuuggagaggaugcuuugggcgaggcuccuucugaguucccuggaacgggacgccacagagggugagagccccguauaguuggaagccaagccuguguaaagcuccuucgacgagucgaguaguuugggaaugcugcucaaaaugggagguaaauuucuucuaaagcuaaauaccggccagagaccgauagcgcacaaguagagugaucgaaagaugaaaagcacuuugaaaagaggguuaaauagcacgugaaauuguugaaagggaagcgcuugugaccagacuugcgcccggcggaucauccgguguucucaccggugcacuccgccgggcucaggccagcaucgguucuggcggggggauaaaggcccagggaauguggcuccuccgggaguguuauagcccuggguguaauacccucgccgggaccgaggaccgcgcucugcaaggaugcuggcguaauggucaccagcgacccgucuugaaacacggaccaaggagucaagguuuugcgcgaguguuuggguguaaaacccgcacgcguaaugaaagugaacguaggugagagcuucggcgcaucaucgaccgauccugauguauucggauggauuugaguaggagcguuaagccuuggacccgaaagauggugaacuaugcuuggauagggugaagccagaggaaacucugguggaggcucgcagcgguucugacgugcaaaucgaucgucaaaucugagcaugggggcgaaagacuaaucgaaccaucuaguagcugguuaccgccgaaguuucccucaggauagcagugucgaccuucaguuuuaugagguaaagcgaaugauuagggacucgggggcgauuuuuagccuucauccauucucaaacuuuaaauauguaagaagcccuuguuacuuaacugaacgugggcauucgaauguaucgacacuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacgcgggguuaaggugccggaguggacgcucaucagacaccacaaaaggcguuaguacaucuugacagcaggacgguggccauggaagucggaauccgcuaaggacuguguaacaacucaccugccgaauguacuagcccugaaaauggauggcgcucaagcgucccacccauaccccgcccucaggguagaaacgaugcccugaggaguaggcggccguggaggucagugacgaagccuagggcgugagcccgggucgaacggccucuagugcagaucuuggugguaguagcaaauacuucaaugagaacuugaaggaccgaaguggggaaagguuccaugugaacagcgguuggacauggguuagucgauccuaagccauagggaaguuccguuucaaaggggcacucgugccccguguggcgaaagggaagccgguuaauauuccggcaccuggauguggguuuugcgcggcaacgcaacugaacgcggagacgacggcgggggccccgggcagaguucucuuuucuucuuaacggucuaucacccuggaaacaguuugucuggagauaggguuuaauggccggaagagcccgacacuucugucggguccggugcgcucucgacgucccuugaaaauccgcgggagggaauaauucucacgccaggucguacucauaaccgcagcagguccccaaggugaacagccucugguugauagaacaauguagauaagggaagucggcaaaauagauccguaacuucgggaaaaggauuggcucuaaggguugggcacguugcggcgugcgguuaacaaccaacuuagaacugguacggacagggggaaucugacugucuaauuaaaacauagcauugcgauggccagaaagugguguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcaaaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaaaagacauaggagcuccuauuguuuuuuuacuuauucaaugaagcggggcuggacuugcguccaacuucuggaguuaagguccuucgcgggccgacccggguugaagacauugucagguggggaguuuggcugnggcggcacaucuguuaaaccauaacgcagguguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaaguccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucgaaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaacucgucgcaaugguaauucagcuuaguacgagaggaaccgcugauucagauaauugguuuuugcgguuguccgaccgggcagugccgcgaagcuaccaucugcuggauaauggcugaacgccucuaagucagaauccaugccagaacgcgacgauacuacccgcacguuguagacguauaagaauaggcuccggccucguauccuagcaggcgauuccuccgccggccucgaaguggccgucgguaauucgcguauugcaauuuagacacgcgcgggaucaaauccuuugcagacgacuuagaugugcgaaaggguccuguaagcaguagaguagccuuguuguuacgaucugcugaggguaagcccuccuucgccuagauuu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<......<<.....>>.....>>>>...[[[..<<.......<<.<<<....>>>.>>.......>>....<<<<<.<<<<<<<<<..<<<<<<..<<....<<<<......>>>>.((......<<<.....))>>>....>>..>>.>>>>..>>>>....>>>>>>>>.>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<.<<<<<<.....<<.<<<<<<<<<<....<<<<<<....>>>>>>.....>>>>>>>>>>.>>.<<<<<<<.<<<<<<<<<<<<<<<.....<.<<<<<<<<......<<<<<....>>>>>.......>>>>>>>>....>.>>>>>>>>>>>>>>>........<<...>>.....>>>>>>>.....>>>>>>.>>>>..<<<<........>>>><<<<<<....<<<<<<<<.<<<<..<<<..<<<<<.....>>>>>..>>>...<<....>>.......<<<<<..<<<..>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>.>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<..<<........>>.>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>...<<<<<....<.<<<....>>>.><<<<<<<<<.....<<.<<<<<<<.....<<<....<<<....<<<...<<<<<<........>>>>>>.>>>....>>>..>>.>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>...>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<((......<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>...........)).>>...>>>>>>.>>>...>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<....<<.....>>..>>>>>....((<<<<<<...<<<...<<<....>>>........<<<<<......>>>>>....>>>....>>...<<<<<........>>>>>))<<<<.<<<<.<<<....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<.<<<<.......>>>>.><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>.........>>>...>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<.<<<<<<<..>>>>>>>......>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<....<<<<<....>>>>.>...>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<<<.<<<<..>>>>..>>>>>>>>>>>...<<<<<.....<<<<..<<<<<....>>>>>..............<<<<<.....>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<..<<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>..>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<..<<<<.<.<<<<<.................>>>>>.><<<<<...<<<<....<<<<<<<<<<....>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<.............>>>>...>>>>.>>>>....>>>>>>>.....<<<<<....<<<......<<.......<<<<..>>>>....>>........<<<<.....<<<.<<<<<.......>>>>>.>>>....>>>>..............>>>...>>>>>...<<<<<<<.............>>....<<<<<<<<<.<<<....<<<<.<..<<<<<......>>>>>..>>>>>...>>>....>>>>..>>>>>...>>>>> .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.(((....))).))....)........(((((.(((((((((..((((((..((..({((((......)))))[[(...).(((....}]])))....))..)).))))..))))....)))))))).))...)....(((((((........))))))).....((.((..[[[[[[)).))..)))..................................((....))............(..((((....))))............).....................((((.((((((.....((.(((((((((((...((((((....))))))...).)))))))))).)).(((((((((((((((((((((((.......((((((((......(((((....))))).......))))))))......)))))))))))))))........((...))....)))))))).....)))))).)))).<((((........))))((((((....((((((((.((((..(((...(((.......)))...)))...((....)).......(((((..((....))...))))).((((((((....(....)....))).))).))....)))).))))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)<)))...(((..((.((........)))).)))....))))))))).(.((.......))...)..))))))......).))...(((((....(.(((....))).)(((((((((.....((.(((((((.....(((....(((..(.(((...(.((((........)))).).))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))...))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[....(.((((((......(..........(((.((((((((((.....{.(((((..((...((.........))...))......(...((......)).).)))))...)))))))))))))...........]].)....))))))))))...)))))))(((((((((.........)))))))))....))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((..(((((((...((.....)).))))))....[[(((.((...(((...(((....)))........(((((......)))))....)))....))...(((((........)))))]]((((..(((((((...((((....)))...(.[[((((((...((((.(((((((((((((.((((...{{..)))).)(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....))).).))).)))).))).))).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((.(((((..()..)))))......)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.((((((((..((((((((((((((((()))))).)))))))))))....((((.....((((..(((((....)))))..........]]..(((((.....)))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(..(((((...((.......))...)))))....)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))....))..))).)))))....(((((((..(((..(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...))))..)))....))))))).....(((((.((..((....(.((.......(((....)))....))).......((((.....(((.(((((.......))))).)))....))))..............)).)).)))))...(((((((..(.......)..))..(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....))))..))))))..))))) Cryo-EM structure of the ribosome-associated RAC complex on the 80S ribosome - RAC-1 conformation; 26S rRNA 7z3n 2 1772 3.2 RF01960,RF02542,RF01959,RF00177 URS00026813EF_759272 37081320 0003735 0005840 759272 uaccugguugauucugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuauacagcgaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguaccuuacuacauggauaaccgugguaauucuagagcuaauacaugcugaaaaucccgacuucggaagggauguauuuauuagauuaaaaaccaaugcccuucggggcuuucuggugauucauaauaacuucucgaaucgcacggccuugcgccggcgaugguucauucaaauuucugcccuaucaacuuucgacggcuggguauuggccagccguggugacaacggguaacggaggguuagggcucgaccccggagaaggagccugagaaacggcuacuacauccaaggaaggcagcaggcgcgcaaauuacccaaucccgacacggggagguagugacaauaaauacugauacagggcucuuucgggucuuguaauuggaaugaguacaauuuaaaucccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugagguuaaaaagcucguaguugaaccuugggccuagcccgccgguacuggcugggcugggccuuuccuucuggagaaccgcaugccggugugucggggaaccaggacuuuuacucugaacaaauuagaucgcuuaaagaaggccuaugcuugaauacauuagcauggaauaauagaauaggacgugugguucuauuuuguugguuucuaggaccgccguaaugauuaauagggacagucgggggcgucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacaacugcgaaagcauucgccaaggauguuuucauuaaucaggaacgaaaguuaggggaucgaagacgaucagauaccgucguagucuuaaccauaaacuaugccgauuagggaucggacggcguuuauuuuugacccguucggcaccuuacgauaaaucaaaauguuugggcuccugggggaguauggucgcaaggcugaaacuuaaagaaauugacggaagggcaccaccagggguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacgaugaggauugacagauugagagcucuuucuugauuucgugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccugcuaaauagcccguauugccuuggcaguacgccggcuucuuagagggacuaucggcucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagauguucugggccgcacgcgcgcuacacugacagagccagcgaguacucccuuggccgagaggcccggguaaucuuguuaaacucugucgugcuggggauagagcauugcaauuauugcucuucaacgaggaaucccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuacuaccgauugaacggcucagugaggcuuucggacuggcccagagaggucggcaacgaccacucagggccggaaaguuauccaaacucggucguuuagaggaaguaaaagucguaacaaggucuccguaggugaaccugcggagggaucauuu ...<<<<<.{.[[[[>>>>><<<<.<<<<<<...<.<..........<<<.<<<..<<....<<....<<.........>>...>>.>>......<<........<<<..<<..<<....<<<...............<<.....<..<<.......>>..>......>>........<<<<<..........>>>>><.<.<<<<<<......(((((((.<<<<....>>>>..............>>>>>>.>...>...<<...<<<<.....>>>>..>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>...<<<..>>>.....>>>>>>.........<<<....<<<.....>>>..>>>.......>.>....<<<<<<<<<<<<<......>>>>>>>>.>>>>>.....<<.................>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>>.........<<<[[.....<.<<...<<<.<<....<<<<<<<<<<<<<<<....>>>>.>>>>>>>>>>>....<<<<<<....<<<.<.<<..>>.>..>>>....>>>>>>...<<<<<.<<.......<<..<<.......>>.<<<....>>>....>>......>>.>>..>>>.........<<<.<<<<<<<<<.....))))))).>>>>>>>>>>>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>..>>.>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<.......>>>>>>>>>>>..>>>...<<..]]>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..]]]].}<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<..<...<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<.....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<<<<<<<<....>>>>>>>>..>>>>..>>>>.>>...<<<<<<......>>>>>>......>>>>>.....>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<<.<<<<....>>>>.>>>....>>.......>>>>>>>......<....<<<<<<..........>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<.<..<...<<<<<<<.<<<.<<<<<....>>>>>.>>>.>>>>>>>...>..>.>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((.........))...)){))......(((.......(((......((....(((...............((.....(..((.......))..)......))........(((((..(....)..)))))(.(.(.((((......[[[[[[[.((((....)))).....(......).)))).).)...)...(.....((((..).)))....)....)))...))....))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).))...((....)).....)))))).).....(.(((....(((.}...)))..)))).)....).)....((((((((.(.(((....))).).))).)))))...(.(.(.(...........))..)......)..((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{.......(({{...(.(.((....((.((....(((((((((((((((....)))).)))))))))))....(.((((....((((...(.)....).)))....)))).)...((.((.((.......((..((.......)).(((....)))....))......)).))...)).........(((.((.((((((.....]]]]]]].)))))).))))).....))...(((.(((.((...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)).)))..))..)))....)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..(((.((((.(((.......)))))).))))..)))...(...}}.)...))...}.))))))..(((......((((....))))....)))...]]].](((((.((((((...((..(((((..(((.(..(((.......(........)...........(((((..(...(((((........((.(((........))).))......)))))....(.(((...(.((((((....(((.((.((....))...(.((......)))...)).)))....(((((..(..(.((..((((((((.(((....))).))))..))))..)).).)...(.((((.(....).))))....)..)))))....))).))).....).))))......).)))))...)).)..).))).(...(((((((......((.....(((.((((....)))).)))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))....))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..((.(..(...(((((.(.(((.(((((....))))).))).).)))))...)..).))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>........ Cryo-EM structure of the ribosome-associated RAC complex on the 80S ribosome - RAC-1 conformation; 18S rRNA 7z3n 3 119 3.2 RF00001 URS00006BED5F_759272 37081320 0003735 0005840 759272 acauacgaccauaccuaguggaaaacucgggaucccguccgcucucccauagauaagccacuaagggcgggguuaguacucaggucggugacgacuggggaaucccccguguuguaugu <<<<<<<<<....<<<<<<<<.....<<<<<<............>>>>...>>....>>>>>>.>><<<<<<......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>> (((((((((....((((((((......(((((...(....)...))))...).....)))))).))((((((......(((((..((....)).))))).....))))))))))))))) Cryo-EM structure of the ribosome-associated RAC complex on the 80S ribosome - RAC-1 conformation; 5S rRNA 7z3n 4 156 3.2 RF00002 URS000029C274_759272 37081320 0003735 0005840 759272 aaacuuucaacaacggaucucuugguucuggcaucgaugaagaacgcagcgaaaugcgauaaguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgcccgccgguauuccggcgggcaugccuguucgagcgucau .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))................... Cryo-EM structure of the ribosome-associated RAC complex on the 80S ribosome - RAC-1 conformation; 5.8S rRNA 7z3o 1 3191 3.3 RF02543 URS000051B013_759272 37081320 0003735 0005840 759272 guugaccucggaucagguaggaggacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaacagggauugcccuaguaacggcgagugaagcggcaacagcucaaauuugaaagcuggcuucggcccgcguuguaauuuggagaggaugcuuugggcgaggcuccuucugaguucccuggaacgggacgccacagagggugagagccccguauaguuggaagccaagccuguguaaagcuccuucgacgagucgaguaguuugggaaugcugcucaaaaugggagguaaauuucuucuaaagcuaaauaccggccagagaccgauagcgcacaaguagagugaucgaaagaugaaaagcacuuugaaaagaggguuaaauagcacgugaaauuguugaaagggaagcgcuugugaccagacuugcgcccggcggaucauccgguguucucaccggugcacuccgccgggcucaggccagcaucgguucuggcggggggauaaaggcccagggaauguggcuccuccgggaguguuauagcccuggguguaauacccucgccgggaccgaggaccgcgcucugcaaggaugcuggcguaauggucaccagcgacccgucuugaaacacggaccaaggagucaagguuuugcgcgaguguuuggguguaaaacccgcacgcguaaugaaagugaacguaggugagagcuucggcgcaucaucgaccgauccugauguauucggauggauuugaguaggagcguuaagccuuggacccgaaagauggugaacuaugcuuggauagggugaagccagaggaaacucugguggaggcucgcagcgguucugacgugcaaaucgaucgucaaaucugagcaugggggcgaaagacuaaucgaaccaucuaguagcugguuaccgccgaaguuucccucaggauagcagugucgaccuucaguuuuaugagguaaagcgaaugauuagggacucgggggcgauuuuuagccuucauccauucucaaacuuuaaauauguaagaagcccuuguuacuuaacugaacgugggcauucgaauguaucgacacuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacgcgggguuaaggugccggaguggacgcucaucagacaccacaaaaggcguuaguacaucuugacagcaggacgguggccauggaagucggaauccgcuaaggacuguguaacaacucaccugccgaauguacuagcccugaaaauggauggcgcucaagcgucccacccauaccccgcccucaggguagaaacgaugcccugaggaguaggcggccguggaggucagugacgaagccuagggcgugagcccgggucgaacggccucuagugcagaucuuggugguaguagcaaauacuucaaugagaacuugaaggaccgaaguggggaaagguuccaugugaacagcgguuggacauggguuagucgauccuaagccauagggaaguuccguuucaaaggggcacucgugccccguguggcgaaagggaagccgguuaauauuccggcaccuggauguggguuuugcgcggcaacgcaacugaacgcggagacgacggcgggggccccgggcagaguucucuuuucuucuuaacggucuaucacccuggaaacaguuugucuggagauaggguuuaauggccggaagagcccgacacuucugucggguccggugcgcucucgacgucccuugaaaauccgcgggagggaauaauucucacgccaggucguacucauaaccgcagcagguccccaaggugaacagccucugguugauagaacaauguagauaagggaagucggcaaaauagauccguaacuucgggaaaaggauuggcucuaaggguugggcacguugcggcgugcgguuaacaaccaacuuagaacugguacggacagggggaaucugacugucuaauuaaaacauagcauugcgauggccagaaagugguguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcaaaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaaaagacauaggagcuccuauuguuuuuuuacuuauucaaugaagcggggcuggacuugcguccaacuucuggaguuaagguccuucgcgggccgacccggguugaagacauugucagguggggaguuuggcugnggcggcacaucuguuaaaccauaacgcagguguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaaguccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucgaaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaacucgucgcaaugguaauucagcuuaguacgagaggaaccgcugauucagauaauugguuuuugcgguuguccgaccgggcagugccgcgaagcuaccaucugcuggauaauggcugaacgccucuaagucagaauccaugccagaacgcgacgauacuacccgcacguuguagacguauaagaauaggcuccggccucguauccuagcaggcgauuccuccgccggccucgaaguggccgucgguaauucgcguauugcaauuuagacacgcgcgggaucaaauccuuugcagacgacuuagaugugcgaaaggguccuguaagcaguagaguagccuuguuguuacgaucugcugaggguaagcccuccuucgccuagauuu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<....>>>.>>.......>>....<<<<<.<<<<<<<<<..<<<<<<...<....<<<<......>>>>.((......<<<.....))>>>....>...>>.>>>>..>>>>....>>>>>>>>.>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<.<<<<<<.....<<.<<<<<<<<<<....<<<<<<....>>>>>>.....>>>>>>>>>>.>>.<<<<<<<.<<<<<<<<<<<<<<<.....<.<<<<<<<<......<<<<<....>>>>>.......>>>>>>>>....>.>>>>>>>>>>>>>>>........<<...>>.....>>>>>>>.....>>>>>>.>>>>..<<<<........>>>><<<<<<....<<<<<<<<.<<<<..<<<..<<<<<.....>>>>>..>>>...<<....>>.......<<<<<..<<<..>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>.>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<..<<........>>.>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>...<<<<<....<.<<<....>>>.><<<<<<<<<.....<<.<<<<<<<.....<<<....<<<....<<<...<<<<<<........>>>>>>.>>>....>>>..>>.>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>...>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>...>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<....<<.....>>..>>>>>....((<<<<<<...<<<...<<<....>>>........<<<<<......>>>>>....>>>....>>...<<<<<........>>>>>))<<<<.<<<<.<<<....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<.<<<<.......>>>>.><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>.........>>>...>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<.<<<<<<<..>>>>>>>......>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<....<<<<<....>>>>.>...>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<<<.<<<<..>>>>..>>>>>>>>>>>...<<<<<.....<<<<..<<<<<....>>>>>..............<<<<<.....>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<....<<<<<<.......>>>>>>.....<<...(((>>.....>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<..<<<<<..<.<<<<<<<......>>>>>>..>.>.<<<.........>>>.....>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<..<<<<.<.<<<<<.................>>>>>.><<<<<...<<<<....<<<<<<<<<<....>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>.....<<<<<.<..<<<......<<.......<<<<..>>>>....>>........<<<<.....<<<.<<<<<.......>>>>>.>>>....>>>>..............>>>.>.>>>>>...<<<<<<<.............>>....<<<<<<<<<.<<<....<<<<.<..<<<<<......>>>>>..>>>>>...>>>....>>>>..>>>>>...>>>>> .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.(((....))).))....)........(((((.(((((((((..((((((..((..({((((......)))))[[(...).(((....}]])))....))..)).))))..))))....)))))))).))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((.((((((.....((.(((((((((((...((((((....))))))...).)))))))))).)).(((((((((((((((((((((((.......((((((((......(((((....))))).......))))))))......)))))))))))))))........((...))....)))))))).....)))))).)))).<((((........))))((((((....((((((((.((((..(((...(((.......)))...)))...((....)).......(((((..((....))...))))).((((((((....(....)....))).))).))....)))).))))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)<)))...(((..((.((........)))).)))....))))))))).(.((.......))...)..))))))......).))...(((((....(.(((....))).)(((((((((.....((.(((((((.....(((....(((..(.(((...(.(((((.....).)))).).))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))...))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.......(((((..((...((.........))...))......(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((..(((((((...((.....)).))))))....[[(((.((...(((...(((....)))........(((((......)))))....)))....))...(((((........)))))]]((((..(((((((...((((....)))...(.[[((((((...((((.(((((((((((((.((((...{{..)))).)(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....))).).))).)))).))).))).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((.(((((..()..)))))......)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.((((((((..((.((((((((.((((()))))..)))))))).))....((((.....((((..(((((....)))))..........]]..(((((.....)))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((.(.(.((((((.......))))))...).((][.[[[))....).))))).(.(((..((((....{..))))..))))(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(..(((((...((.......))...)))))....)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))....))..))).)))))....(((((((..(((..(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.............))))...))))..)))....))))))).....(((((.((..((....(.((.......(((....)))....))).......((((.....(((.(((((.......))))).)))....))))..............)).)).)))))...(((((((..(.......)..))..(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....))))..))))))..))))) Cryo-EM structure of the ribosome-associated RAC complex on the 80S ribosome - RAC-2 conformation; 26S rRNA 7z3o 2 1765 3.3 RF01960,RF02542,RF01959,RF00177 URS00026813EF_759272 37081320 0003735 0005840 759272 uaccugguugauucugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuauacagcgaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuacauggauaaccgugguaauucuagagcuaauacaugcugaaaaucccgacuucggaagggauguauuuauuagauuaaaaaccaaugcccuucggggcuuucuggugauucauaauaacuucucgaaucgcacggccuugcgccggcgaugguucauucaaauuucugcccuaucaacuuucgacggcuggguauuggccagccguggugacaacggguaacggaggguuagggcucgaccccggagaaggagccugagaaacggcuacuacauccaaggaaggcagcaggcgcgcaaauuacccaaucccgacacggggagguagugacaauaaauacugauacagggcucuuucgggucuuguaauuggaaugaguacaauuuaaaucccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugagguuaaaaagcucguaguugaaccuugggccuagcccgccgguacuggcugggcugggccuuuccuucuggagaaccgcaugccggugugucggggaaccaggacuuuuacucugaacaaauuagaucgcuuaaagaaggccuaugcuugaauacauuagcauggaauaauagaauaggacgugugguucuauuuuguugguuucuaggaccgccguaaugauuaauagggacagucgggggcgucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacaacugcgaaagcauucgccaaggauguuuucauuaaucaggaacgaaaguuaggggaucgaagacgaucagauaccgucguagucuuaaccauaaacuaugccgauuagggaucggacggcguuuauuuuugacccguucggcaccuuacgauaaaucaaaauguuugggcuccugggggaguauggucgcaaggcugaaacuuaaagaaauugacggaagggcaccaccagggguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacgaugaggauugacagauugagagcucuuucuugauuucgugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccugcuaaauagcccguauugccuuggcaguacgccggcuucuuagagggacuaucggcucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagauguucugggccgcacgcgcgcuacacugacagagccagcgaguacucccuuggccgagaggcccggguaaucuuguuaaacucugucgugcuggggauagagcauugcaauuauugcucuucaacgaggaaucccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuacuaccgauugaacggcucagugaggcuuucggacuggcccagagaggucggcaacgaccacucagggccggaaaguuauccaaacucggucguuuagaggaaguaaaagucguaacaaggucuccguaggugaaccugcggagggaucauuu ...<<<<<.{.[[[[>>>>><<<<.<<<<<<...<.<..........<<<.<<<..<<....<<....<<.........>>...>>.>>......<<........<<<..<<..<<....<<<........<<.....<..<<.......>>..>......>>........<<<<<..........>>>>><...<<<<<<......(((((((.<<<<<..>>>>>..............>>>>>>.....>...<<<<.<<<<.....>>>>>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>...<<<..>>>.....>>>>>>.........<<<....<<<.....>>>..>>>.......>.>....<<<<<<<<<<<<<......>>>>>>>>.>>>>>.....<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>>.........<<<[[.....<.<<...<<<.<<....<<<<<<<<<<<<<<<....>>>>.>>>>>>>>>>>....<<<<<<....<<<<<<<<..>>>>>.>>>....>>>>>>...<<<<<.<<.......<<..<<.......>>.<<<....>>>....>>......>>.>>..>>>.........<<<.<<<<<<<<<.....))))))).>>>>>>>>>>>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>.>.>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<.......>>>>>>>>>>>..>>>...<<..]]>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..]]]].}<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<......<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<.....<<<.<<<<......>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<<<<<<<<....>>>>>>>>..>>>>..>>>>.>>....<<<<<<....>>>>>>.......>>>>>.....>>.>>>.....>>>>>>>.......>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<<.<<<<....>>>>.>>>....>>.......>>>>>>>......<....<<<<<<..........>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<.<..<...<<<<<<<..<<.<<<<<....>>>>>.>>..>>>>>>>...>..>.>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((.........))...)){))......(((.......(((..((..((....(((....{...((.....(..((.......))..)......))........(((((..........)))))(.(.((((((......[[[[[[...(((....)))......(......).)))))).)...).(}((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).)....((((((((.(((((....))))).))).)))))...(.(.(.(...........))..)......)..((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....(((((((((((((((....)))).)))))))))))....((((((....((((.(((()))).).)))....))))))...((.((.((.......((..((.......)).(((....)))....))......)).))...)).........(((.((.((.(((......]]]]]].))).)).))))).....))...(((.(((.((...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)).)))..))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((.(....))))))))))))..)))...(...}}.)...))...}.))))))).(((......((((....))))....)))...]]].](((((.((((((...((..(((((..(((.(..(((.......(........)...........(((((..(...(((((........((.(((........))).))......)))))....(.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..(.((..((((((((((((....))))))))..))))..)).).))..(.((((.(....).))))....)..)))))....))).))).....).))))......).)))))...)).)..).))).(...(((((((......((.....(((.((((....)))).)))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))....))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..((.(..(...(((((((..((.(((((....))))).))..)))))))...)..).))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>........ Cryo-EM structure of the ribosome-associated RAC complex on the 80S ribosome - RAC-2 conformation; 18S rRNA 7z3o 3 119 3.3 RF00001 URS00006BED5F_759272 37081320 0003735 0005840 759272 acauacgaccauaccuaguggaaaacucgggaucccguccgcucucccauagauaagccacuaagggcgggguuaguacucaggucggugacgacuggggaaucccccguguuguaugu <<<<<<<<<....<<<<<<<<.....<<<<<<............>>>>...>>....>>>>>>.>><<<<<<......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>> (((((((((....((((((((.....((((((...(....)...))))...))....)))))).))((((((......(((((..((....)).))))).....))))))))))))))) Cryo-EM structure of the ribosome-associated RAC complex on the 80S ribosome - RAC-2 conformation; 5S rRNA 7z3o 4 156 3.3 RF00002 URS000029C274_759272 37081320 0003735 0005840 759272 aaacuuucaacaacggaucucuugguucuggcaucgaugaagaacgcagcgaaaugcgauaaguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgcccgccgguauuccggcgggcaugccuguucgagcgucau .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))................... Cryo-EM structure of the ribosome-associated RAC complex on the 80S ribosome - RAC-2 conformation; 5.8S rRNA 7z43 RRR 18 3.123 URS000080E01C_11520 35605026 11520 uauaccucugcuucugcu .................. .................. Influenza B polymerase with Pol II pSer5 CTD peptide mimic bound in site 1B and 2B; RNA (5'-R(*UP*AP*UP*AP*CP*CP*UP*CP*UP*GP*CP*UP*CP*CP*UP*GP*CP*U)-3') 7z43 VVV 14 3.123 URS000080E200_11520 35605026 11520 aguaguaacaagag .<<....>>..... .((....))..... Influenza B polymerase with Pol II pSer5 CTD peptide mimic bound in site 1B and 2B; RNA (5'-R(P*AP*GP*UP*AP*GP*UP*AP*AP*CP*AP*AP*GP*AP*G)-3') 7zag 2 1497 2.77 RF01959,RF00177,RF01960,RF02542 URS00023359D6_272844 35694843 0003735 0005840 272844 auucnggnugauccugccggaggccacugcuaugggggucngacuaagccangcgagucaagggggcgucccuucugggacgccaccggcggacggcucaguaacacgucgguaacnuacccucgggagggggauaaccccgggaaacuggggcuaaucccccauaggccugggguacuggaagguccccaggccgaaagggagccguaaggcuccgcccgaggaugggccggcggcngauuagguaguuggugggguaacggcccaccaagcngaagaucgguacgggcngugagagcgggagccnggagauggacacugagacacggguccaggcccuacggggcgcagcaggcgcganaccucngcaaugcgggaaacngcgacggggggacccccagugccgugccucuggcacggcuuuuccggaguguaaaaagcuccgggaauaaggncugngcaaggcngguggcagccgccgcgguaauaccggcggccngaguggungccacuauuauugggncuaaagcggcnguagccgggcccguaagucccuggcgaaaucccacggcucaacnguggggcucgcuggggauacugcgggccuugggacngggagaggcnggggguacccccgggguaggngugaaauccuauaaucccggggngaccgccaguggngaaggcgccnggcuggaacgggucngacggugagggcngaaggccaggggagcgaacnggauuagauacccggguagucnnggcuguaaaggangcgggcuaggugucgggcgagcuucgagcucgcccggugcngnagggaagcnguuaagncngcngccuggggaguacggcngcaangnugaaacuuaaaggaauuggcgggggagcacuacaaggnguggagcgugcgguuuaauungauncaacgccgggaaccucacngggggcgacggcaggaugaaggccaggcugaaggucuugccggacgcgccgagaggaggugcauggcngcngucagcunguanngugaggcguccacuuaagugugguaacnagcgagacccgcgcccccaguugccagucccucccgcucgggagggaggcacucuggggggacugccggcgauaagcnggaggaaggggcgggcgacgguaggucagnaugcccngaaacccccgggcuacangcgcgcuacaaugggcgggacaaugggugcngacccngaaagggggagguaauccccuaaacccgcccucaguucggaucgcgggcugcaacucgcccgcgugaagcuggaaucccuaguacccgcgcgucaucaucgcgcggcgaauacgucccugcuccuugcacacacngnccgncacuccacccgagcggggccuaggugaggcccgaucuccuucgggaggucgggucgagccuaggcuccgugaggggggagaagucgnancaagguagcnguaggggnnccuacggnungaucacnuccu ...<<<<<.[.((((>>>>>.<<<<<<<<<..<<<<<<.<<......<<<.<<<..<<<..<<.<<<<<<<<....>>>>>>>>.>>>>>......<<........<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<<....>>>>>>.....>>>>>...<<<<<<<<<.<<......>>>>>>>>>>>.....<<<<<<....>>>>>>.>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<............>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<<<<<...>>>>>>>>...<<<<<<<<.......>>>>>>>>.....<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<....<<<<<<<<.....>>>>>>>>...>>>>>>>>..>>>>>>>>>...<<<<<<.....<<<<<<<<<..<<<<<<<<<..<<<......>>>.....>>>>>>>>>..>>.......<<....>>.>>>>>>>....>>>.>>>...>>>...>>>>...<<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>>.........<<<<<<..<<<<<<<<<<<<<<.....>>>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<...<<<<........<<<.<<<.......>>>.>>>......>>>>...<<.<<<..<<<<<<<<<....<<<<<<.<<....>>...<<<<......>>>>..>>>>>>....<<<<<.<<<<<<<..<<<..<<<<<<<<....>>>>>>>>>>>...>>>>>>>.....<<<<<.....>>>>>........>>>>>....>>>.>>>...>>>>>>>>....>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>.....<<<<<<<.......>>>>>>>.......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<..<<<<<<<<<<<<....>>>>>>>>>>>>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ ...((((..[.[[[..)))).(((((((((..((((((.(((.....(((.(((..(((..((.((((((((....)))))))).)))))......(((.......(((((((..((...(((((((.(((((....((((((....)))))).....)))))...(((((((((.((......))))))))))).....((((((....)))))).)))))))..))))))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((((((...))))))))....(((((((.......)))))))......((((([[....(.((((.....((..]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((.....(((((((.....)))))))....))))))))..)))))))))..(((((((.....(((((((((..((((((((...((........))......))))))))..)).......((....)).)))))))....))).)))..))))...))))...(((((((...((...((((.........))))...))))))))).....{...((((((..((((((((((((((.....))))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..((((((((((......((........))..........(((((((...((((.(......(((.((((.....)))).)))...)..))))...((.(((...(.((((((....((((((.((....))...((((......))))..))))))....(((((.(((((((..(((..((((((((....)))))))))))...)))))))..(..(((((.....))))).....)..)))))....))).)))....).)))))....)))))))...)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..)))))......(((((((.......))))))).......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((..((((((((((((....))))))))))))..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Cryo-EM structure of a Pyrococcus abyssi 30S bound to Met-initiator tRNA,mRNA, aIF1A and the C-terminal domain of aIF5B.; rRNA 7zag 5 22 2.77 35694843 272844 uggaggugauuuaaaugccaaa ...................... ...................... Cryo-EM structure of a Pyrococcus abyssi 30S bound to Met-initiator tRNA,mRNA, aIF1A and the C-terminal domain of aIF5B.; mRNA 7zag 4 77 2.77 RF00005 URS0000B21E07_272844 35694843 0030533 0006412 272844 agcggggnggagcagccuggnagcucgucgggnucauaacccgaagaucgucggnucaaauccggcccccgcuacca <<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.........)))).(((((.......))))).......(((.......)))..))))))).... Cryo-EM structure of a Pyrococcus abyssi 30S bound to Met-initiator tRNA,mRNA, aIF1A and the C-terminal domain of aIF5B.; Met-tRNAiMET 7zah 2 1497 2.7 RF01959,RF00177,RF01960,RF02542 URS00023359D6_272844 35694843 0003735 0005840 272844 auucnggnugauccugccggaggccacugcuaugggggucngacuaagccangcgagucaagggggcgucccuucugggacgccaccggcggacggcucaguaacacgucgguaacnuacccucgggagggggauaaccccgggaaacuggggcuaaucccccauaggccugggguacuggaagguccccaggccgaaagggagccguaaggcuccgcccgaggaugggccggcggcngauuagguaguuggugggguaacggcccaccaagcngaagaucgguacgggcngugagagcgggagccnggagauggacacugagacacggguccaggcccuacggggcgcagcaggcgcganaccucngcaaugcgggaaacngcgacggggggacccccagugccgugccucuggcacggcuuuuccggaguguaaaaagcuccgggaauaaggncugngcaaggcngguggcagccgccgcgguaauaccggcggccngaguggungccacuauuauugggncuaaagcggcnguagccgggcccguaagucccuggcgaaaucccacggcucaacnguggggcucgcuggggauacugcgggccuugggacngggagaggcnggggguacccccgggguaggngugaaauccuauaaucccggggngaccgccaguggngaaggcgccnggcuggaacgggucngacggugagggcngaaggccaggggagcgaacnggauuagauacccggguagucnnggcuguaaaggangcgggcuaggugucgggcgagcuucgagcucgcccggugcngnagggaagcnguuaagncngcngccuggggaguacggcngcaangnugaaacuuaaaggaauuggcgggggagcacuacaaggnguggagcgugcgguuuaauungauncaacgccgggaaccucacngggggcgacggcaggaugaaggccaggcugaaggucuugccggacgcgccgagaggaggugcauggcngcngucagcunguanngugaggcguccacuuaagugugguaacnagcgagacccgcgcccccaguugccagucccucccgcucgggagggaggcacucuggggggacugccggcgauaagcnggaggaaggggcgggcgacgguaggucagnaugcccngaaacccccgggcuacangcgcgcuacaaugggcgggacaaugggugcngacccngaaagggggagguaauccccuaaacccgcccucaguucggaucgcgggcugcaacucgcccgcgugaagcuggaaucccuaguacccgcgcgucaucaucgcgcggcgaauacgucccugcuccuugcacacacngnccgncacuccacccgagcggggccuaggugaggcccgaucuccuucgggaggucgggucgagccuaggcuccgugaggggggagaagucgnancaagguagcnguaggggnnccuacggnungaucacnuccu ...<<<<<.[.((((>>>>>.<<<<<<<<<..<<<<<<.<<......<<<.<<<..<<<..<<.<<<<<<<<....>>>>>>>>.>>>>>......<<........<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<<<<<.<<......>>>>>>>>>>>.....<<<<<<....>>>>>>.>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<............>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<<<<<...>>>>>>>>...<<<<<<<<.......>>>>>>>>.....<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<....<<<<<<<<.....>>>>>>>>...>>>>>>>>..>>>>>>>>>...<<<<<<.....<<<<<<<<<..<<<<<<<<<..<<<......>>>.....>>>>>>>>>..>>.......<<....>>.>>>>>>>....>>>.>>>...>>>...>>>>...<<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>>.........<<<<<<..<<<<<<<<<<<<<<.....>>>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<...<<<<........<<<.<<<<.....>>>>.>>>......>>>>...<<.<<<..<<<<<<<<<....<<<<<<.<<....>>...<<<<......>>>>..>>>>>>....<<<<<.<<<<<<<..<<<..<<<<<<<<....>>>>>>>>>>>...>>>>>>>.....<<<<<.....>>>>>........>>>>>....>>>.>>>...>>>>>>>>....>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>.....<<<<<<<.......>>>>>>>.......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<..<<<<<<<<<<<<....>>>>>>>>>>>>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ ...((((..[.[[[..)))).(((((((((..((((((.(((.....(((.(((..(((..((.((((((((....)))))))).)))))......(((.......(((((((..((...(((((((.(((((....((((((....)))))).....)))))...(((((((((.((......))))))))))).....((((((....)))))).)))))))..))))))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((((((...))))))))....(((((((.......)))))))......((((([[....(.((((.....((..]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((.....(((((((.....)))))))....))))))))..)))))))))..(((((((.....(((((((((..((((((((...((........))......))))))))..)).......((....)).)))))))....))).)))..))))...))))...(((((((...((...((((.........))))...))))))))).....{...((((((..((((((((((((((.....))))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..((((((((((......((........))..........(((((((...((((.(......(((.((((.....)))).)))...)..))))...((.(((...(.((((((....((((((.((....))...((((......))))..))))))....(((((.(((((((..(((...(((((((....))))))).)))...)))))))..(..(((((.....))))).....)..)))))....))).)))....).)))))....)))))))...)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..)))))......(((((((.......))))))).......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((..((((((((((((....))))))))))))..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Cryo-EM structure of a Pyrococcus abyssi 30S bound to Met-initiator tRNA, mRNA, aIF1A and aIF5B; 16S rRNA 7zah 5 22 2.7 35694843 272844 uggaggugauuuaaaugccaaa ...................... ...................... Cryo-EM structure of a Pyrococcus abyssi 30S bound to Met-initiator tRNA, mRNA, aIF1A and aIF5B; mRNA 7zah 4 77 2.7 RF00005 URS0000B21E07_272844 35694843 0030533 0006412 272844 agcggggnggagcagccuggnagcucgucgggnucauaacccgaagaucgucggnucaaauccggcccccgcuacca <<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))).... Cryo-EM structure of a Pyrococcus abyssi 30S bound to Met-initiator tRNA, mRNA, aIF1A and aIF5B; tRNA-MET 7zai 2 1497 2.6 RF00177,RF01959,RF01960 URS00023359D6_272844 35694843 0003735 0005840 272844 auucnggnugauccugccggaggccacugcuaugggggucngacuaagccangcgagucaagggggcgucccuucugggacgccaccggcggacggcucaguaacacgucgguaacnuacccucgggagggggauaaccccgggaaacuggggcuaaucccccauaggccugggguacuggaagguccccaggccgaaagggagccguaaggcuccgcccgaggaugggccggcggcngauuagguaguuggugggguaacggcccaccaagcngaagaucgguacgggcngugagagcgggagccnggagauggacacugagacacggguccaggcccuacggggcgcagcaggcgcganaccucngcaaugcgggaaacngcgacggggggacccccagugccgugccucuggcacggcuuuuccggaguguaaaaagcuccgggaauaaggncugngcaaggcngguggcagccgccgcgguaauaccggcggccngaguggungccacuauuauugggncuaaagcggcnguagccgggcccguaagucccuggcgaaaucccacggcucaacnguggggcucgcuggggauacugcgggccuugggacngggagaggcnggggguacccccgggguaggngugaaauccuauaaucccggggngaccgccaguggngaaggcgccnggcuggaacgggucngacggugagggcngaaggccaggggagcgaacnggauuagauacccggguagucnnggcuguaaaggangcgggcuaggugucgggcgagcuucgagcucgcccggugcngnagggaagcnguuaagncngcngccuggggaguacggcngcaangnugaaacuuaaaggaauuggcgggggagcacuacaaggnguggagcgugcgguuuaauungauncaacgccgggaaccucacngggggcgacggcaggaugaaggccaggcugaaggucuugccggacgcgccgagaggaggugcauggcngcngucagcunguanngugaggcguccacuuaagugugguaacnagcgagacccgcgcccccaguugccagucccucccgcucgggagggaggcacucuggggggacugccggcgauaagcnggaggaaggggcgggcgacgguaggucagnaugcccngaaacccccgggcuacangcgcgcuacaaugggcgggacaaugggugcngacccngaaagggggagguaauccccuaaacccgcccucaguucggaucgcgggcugcaacucgcccgcgugaagcuggaaucccuaguacccgcgcgucaucaucgcgcggcgaauacgucccugcuccuugcacacacngnccgncacuccacccgagcggggccuaggugaggcccgaucuccuucgggaggucgggucgagccuaggcuccgugaggggggagaagucgnancaagguagcnguaggggnnccuacggnungaucacnuccu ...<<<<<.[.((((>>>>>.<<<<<<<<<..<<<<<<.<<......<<<.<<<..<<<..<<.<<<<<<<<....>>>>>>>>.>>>>>......<<........<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<<....>>>>>>.....>>>>>...<<<<<<<<<.<<......>>>>>>>>>>>.....<<<<<<....>>>>>>.>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<............>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<<<<<...>>>>>>>>...<<<<<<<<.......>>>>>>>>.....<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<....<<<<<<<<.....>>>>>>>>...>>>>>>>>..>>>>>>>>>...<<<<<<.....<<<<<<<<<..<<<<<<<<<..<<<......>>>.....>>>>>>>>>..>>.......<<....>>.>>>>>>>....>>>.>>>...>>>...>>>>...<<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>>.........<<<<<<..<<<<<<<<<<<<<<.....>>>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<...<<<<........<<<.<<<.......>>>.>>>......>>>>...<<.<<<..<<<<<<<<<....<<<<<<.<<....>>...<<<<......>>>>..>>>>>>....<<<<<.<<<<<<<..<<<..<<<<<<<<....>>>>>>>>>>>...>>>>>>>.....<<<<<.....>>>>>........>>>>>....>>>.>>>...>>>>>>>>....>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>.....<<<<<<<.......>>>>>>>.......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<..<<<<<<<<<<<<....>>>>>>>>>>>>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ ...((((..[.[[[..)))).(((((((((..((((((.(((.....(((.(((..(((..((.((((((((....)))))))).)))))......(((.......(((((((..((...(((((((.(((((....((((((....)))))).....)))))...(((((((((.((......))))))))))).....((((((....)))))).)))))))..))))))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((((((...))))))))....(((((((.......)))))))......((((([[....(.((((.....((..]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((.....(((((((.....)))))))....))))))))..)))))))))..(((((((.....(((((((((..((((((((...((........))......))))))))..)).......((....)).)))))))....))).)))..))))...))))...(((((((...((...((((.........))))...))))))))).....{...((((((..((((((((((((((.....))))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..((((((((((......((........))..........(((((((...((((.(......(((.((((.....)))).)))...)..))))...((.(((...(.((((((....((((((.((....))...((((......))))..))))))....(((((.(((((((..(((..((((((((....)))))))))))...)))))))..(..(((((.....))))).....)..)))))....))).)))....).)))))....)))))))...)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..)))))......(((((((.......))))))).......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((..((((((((((((....))))))))))))..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Cryo-EM structure of a Pyrococcus abyssi 30S bound to Met-initiator tRNA, mRNA and aIF1A.; 16S rRNA 7zai 5 22 2.6 35694843 272844 uggaggugauuuaaaugccaaa ...................... ...................... Cryo-EM structure of a Pyrococcus abyssi 30S bound to Met-initiator tRNA, mRNA and aIF1A.; mRNA 7zai 4 77 2.6 RF00005 URS0000B21E07_272844 35694843 0030533 0006412 272844 agcggggnggagcagccuggnagcucgucgggnucauaacccgaagaucgucggnucaaauccggcccccgcuacca <<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>......<<<<.......>>>>.>>>>>>>.... (((((((..((((......[..)))).(((((.......))))).......(((..]....)))..))))))).... Cryo-EM structure of a Pyrococcus abyssi 30S bound to Met-initiator tRNA, mRNA and aIF1A.; tRNA-MET 7zhg 2 1497 2.25 RF00177,RF01959,RF01960 URS00023359D6_272844 35694843 0003735 0005840 272844 auucnggnugauccugccggaggccacugcuaugggggucngacuaagccangcgagucaagggggcgucccuucugggacgccaccggcggacggcucaguaacacgucgguaacnuacccucgggagggggauaaccccgggaaacuggggcuaaucccccauaggccugggguacuggaagguccccaggccgaaagggagccguaaggcuccgcccgaggaugggccggcggcngauuagguaguuggugggguaacggcccaccaagcngaagaucgguacgggcngugagagcgggagccnggagauggacacugagacacggguccaggcccuacggggcgcagcaggcgcganaccucngcaaugcgggaaacngcgacggggggacccccagugccgugccucuggcacggcuuuuccggaguguaaaaagcuccgggaauaaggncugngcaaggcngguggcagccgccgcgguaauaccggcggccngaguggungccacuauuauugggncuaaagcggcnguagccgggcccguaagucccuggcgaaaucccacggcucaacnguggggcucgcuggggauacugcgggccuugggacngggagaggcnggggguacccccgggguaggngugaaauccuauaaucccggggngaccgccaguggngaaggcgccnggcuggaacgggucngacggugagggcngaaggccaggggagcgaacnggauuagauacccggguagucnnggcuguaaaggangcgggcuaggugucgggcgagcuucgagcucgcccggugcngnagggaagcnguuaagncngcngccuggggaguacggcngcaangnugaaacuuaaaggaauuggcgggggagcacuacaaggnguggagcgugcgguuuaauungauncaacgccgggaaccucacngggggcgacggcaggaugaaggccaggcugaaggucuugccggacgcgccgagaggaggugcauggcngcngucagcunguanngugaggcguccacuuaagugugguaacnagcgagacccgcgcccccaguugccagucccucccgcucgggagggaggcacucuggggggacugccggcgauaagcnggaggaaggggcgggcgacgguaggucagnaugcccngaaacccccgggcuacangcgcgcuacaaugggcgggacaaugggugcngacccngaaagggggagguaauccccuaaacccgcccucaguucggaucgcgggcugcaacucgcccgcgugaagcuggaaucccuaguacccgcgcgucaucaucgcgcggcgaauacgucccugcuccuugcacacacngnccgncacuccacccgagcggggccuaggugaggcccgaucuccuucgggaggucgggucgagccuaggcuccgugaggggggagaagucgnancaagguagcnguaggggnnccuacggnungaucacnuccu ...<<<<<.[.((((>>>>>.<<<<<<<<<..<<<<<<.<<......<<<.<<<..<<<..<<.<<<<<<<<....>>>>>>>>.>>>>>......<<........<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<<....>>>>>>.....>>>>>...<<<<<<<<<.<<......>>>>>>>>>>>.....<<<<<<....>>>>>>.>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<............>>>>>.<<<<....>>>>...>>>>>>......<..<<<....<<<<....>>>>..>>>.>>>.>>>>>>..<<<<<<<<...>>>>>>>>...<<<<<<<<.......>>>>>>>>.....<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<....<<<<<<<<.....>>>>>>>>...>>>>>>>>..>>>>>>>>>...<<<<<<.....<<<<<<<<<..<<<<<<<<<..<<<......>>>.....>>>>>>>>>..>>.......<<....>>.>>>>>>>....>>>.>>>...>>>...>>>>...<<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>>.........<<<<<<..<<<<<<<<<<<<<<.....>>>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<...<<<<........<<<.<<<.......>>>.>>>......>>>>...<<.<<<..<<<<<<<<<....<<<<<<.<<....>>...<<<<......>>>>..>>>>>>....<<<<<.<<<<<<<..<<<..<<<<<<<<....>>>>>>>>>>>...>>>>>>>.....<<<<<.....>>>>>........>>>>>....>>>.>>>...>>>>>>>>....>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>.....<<<<<<<.......>>>>>>>.......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<..<<<<<<<<<<<<....>>>>>>>>>>>>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ ...((((..[.[[[..)))).(((((((((..((((((.(((.....(((.(((..(((..((.((((((((....)))))))).)))))......(((.......(((((((..((...(((((((.(((((....((((((....)))))).....)))))...(((((((((.((......))))))))))).....((((((....)))))).)))))))..))))))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((((((...))))))))....(((((((.......)))))))......((((([[....(.((((.....((..]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((.....(((((((.....)))))))....))))))))..)))))))))..(((((((.....(((((((((..((((((((...((........))......))))))))..)).......((....)).)))))))....))).)))..))))...))))...(((((((...((...((((.........))))...))))))))).....{...((((((..((((((((((((((.....))))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..((((((((((......((........))..........(((((((...((((.(......(((.((((.....)))).)))...)..))))...((.(((...(.((((((....((((((.((....))...((((......))))..))))))....(((((.(((((((..(((..((((((((....)))))))))))...)))))))..(..(((((.....))))).....)..)))))....))).)))....).)))))....)))))))...)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..)))))......(((((((.......))))))).......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((..((((((((((((....))))))))))))..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... High-resolution cryo-EM structure of Pyrococcus abyssi 30S ribosomal subunit bound to mRNA and initiator tRNA anticodon stem-loop; rRNA 16S 7zhg 5 17 2.25 35694843 272844 uggaggugauuuaaaug ................. ................. High-resolution cryo-EM structure of Pyrococcus abyssi 30S ribosomal subunit bound to mRNA and initiator tRNA anticodon stem-loop; mRNA 7zhg 4 19 2.25 RF00005 URS0000B21E07_272844 35694843 0030533 0006412 272844 gucgggnucauaacccgaa .<<<<<.......>>>>>. .(((((.......))))). High-resolution cryo-EM structure of Pyrococcus abyssi 30S ribosomal subunit bound to mRNA and initiator tRNA anticodon stem-loop; Met-tRNAiMet 7zjw F 90 2.8 RF01852 URS000014E598_9606 35709277 0030533 0006412 9606 gcccggaugauccucaguggucuggggugcaggcuucaaaccuguagcugucuagcgacagagugguucaauuccaccuuucgggcgcca <<<<<<<.....<<<<......>>>>..<<<<<.......>>>>>..<<<<<....>>>>>.<<<<.......>>>>..>>>>>>>.... (.(((((.(...(.((...[..))..).(((((.......)))))..(((((....))))).((((..]....))))).))))).).... Rabbit 80S ribosome as it decodes the Sec-UGA codon; human Ser-tRNA-Sec 7zjw I 183 2.8 RF00458 URS0002617726_12136 35709277 0043022 12136 aaaaaugugaucuugcuuguaaauaugagagguuaauaaauuacaaguagugcuauuuuuguauuuagcuauuuagcuuuacguuccaggaugccaguggcagccccacaauccaggaagcccucucugcgguuauucagauuagguagucgaaaaaccuaagaaauuuaccuugaggcuucg ...................................................................<<<....>>>......<<...........<...........>.......>>.............(((.(((.(((.<<<<<)))))).)))..........>>>>>.......... ....................................................................((....)).......((...............................)).............((..(((.(((.[[[[[))))))..))..........]]]]].......... Rabbit 80S ribosome as it decodes the Sec-UGA codon; CrPV IRES 7zjw S 46 2.8 RF00031 URS0002616B65_10116 35709277 0001514 10116 caugacggucugccugaaaaccagcccgcugguggggcagucccga ......<<.<<........<<<<<....>>>>>.....>>.>>... ......((.(..........(((......))).......).))... Rabbit 80S ribosome as it decodes the Sec-UGA codon; GPX4 SECIS element 7zjw L5 3764 2.8 RF02543 URS0002616B6F_9986 35709277 0003735 0005840 9986 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcgguggggcgcgggaaauguggcguacggaagacccacuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagngngaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcgugguccggccgugccggcggucucggcggaucuuucccgcuccccguuccuggggguggggucggcgggggaccgccccccggccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggccccggcggggaagguggcccggggggacgccucgccgccgucguccgcggcggcggcgggcgcgaccccuccccggguguuacagccccgccccggcagcagcagcucgccgaaucccggggccgagggagcgagaccugugucgccgcgcucuccccccucgggggggccgggccgccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgugucacgccgucgggcucgggggaggccacggcgcgucgcgcgccggcgcgcgcgcgcgagcgagcgcacggggucggcggcgaugucggcuacccacccgacccnucuugnaacncggaccaaggagunuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcggcggcgccgucgucggccgaggugggaucccgaggcccuuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccnanagauggugancuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauagnggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcaaccccgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcngaacuggcgnugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgcuggcagucggcagagcgagaaagagaguggagccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaunuuggugguagunnnaaauauucaaacgagaacuuugaaggccgaaguggngaaggguuccaugngaacagnanuugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucagccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccnuauccgcagcaggucuncaaggugaacngccucuggnauguuggaacaanguagguaagggaagucggcaagcnggauccguaacuucnggauaaggauuggcucuaagggcugguagcagccgacuuagaacuggugcggaccaggngaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugccnagugcucugaaugucanagugangaaauucaaugaagcgcggnuaaacggcgggaguancuaugacucucuuaagguagcnaanugccucnucaucuaauuagugangcgcaugaauggaugancgagnuucccacugunccuaccuacuauccagcgaaaccacngncaagggaacgggcuuggnggaaucagcggngaaagaagacccuguugagcuugacncuagucuggcacggugaanagacaugagagguguagaauaagugggaggcccgggccgccggugaaauaccacuacucuuaucguuuuuucacugacccggugaggcgggggggcgagccccgaggggcucucgcuucuggcgccaagcgccgggccccgucgguccgggccggcggcggccgggcgcgacccgcuccggggacagugccagguggggaguuugacugnggcgguacaccugucaaacgguancgcaggnnuccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucagnacgaauacagaccgugaaagcggggccucacgauccuucugagcuuuuggguuuuaagcaggangugucagaaaaguuaccacagngauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuungaugucggnucuuccuaucauugugaagcagaauucaccaagcguungaunnuucacccacuaauagggaacgugngcugggnuuagancgucgugagacagguuaguuuuacccuacugaugnuguguuguugccaugguanuccugcucaguacgagaggaaccgcagnuncanacauuugguguaunugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgaaggagccucgguuggccucggauagccggucccccgcgggguccggugcggagagcccuucgucccgggaaauggggcgcggccggaaagggggccgcccucucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>>..<<<<<<<<<....<<<<<<<<.<<<....<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>>>>>>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<......>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<<....<<<<<<<.<<<<<.<.....<<<<<.<<<..<<<<<<<<<<<<<<<..>>>>>>>>>..>>>>>>>>>>>>>>.>>>>>>>>>>...>>>.>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<<<<<<<<<<<<<<<<<...<<..<<<..<<<<<<<......<<<<<<<<<<......<<<<<<<<<<<<..>>>>>>>>>>>>..........>>>>>>>>>>.......>>>>>>>..>>>.........>>>>>>..>>>>>>>>>>>.....<<.....[[>>......<<<<<..<<<<<<<.>>>>>>>.<<<<<<.<<<<.<<<<<<<<<.<<<<<<<<..<<<<.<<<<....>>>>.>>>>..>>>>>.>>>.>>>>>>.>>>...>>>>..>>>>.>><<<<<..<<<.<<..>>.>>>.>>>>>.....>>>>>.....>>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<<<<...<<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<.....<......>.....>>>>..<<<<<...<<<..<<....((((.{{..>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>>.<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<..........<<<.<<<<<<<<<...<<<....<<<..<.<<<..<<<<<<.<.....>.>>>>>>>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<.......]]...........}}.))))..............>>>>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<<<<<...>>>>>>>>>>>......>>....>>...<<<<<........>>>>>))<<<<....<<<<<..<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<....>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<<..<<<<<<<..........<<<<<..<........>............>>>>>.>>>>>>>..>>>>>.>>>...<<<<<.....<<<.<....<<<<<<<..>>>>>>>................<<<<<.<<<<.<<<<.<<....>>.>>>>..>>>>.>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>><<<<....>>>>>>)))].....<<<<<<<..<<<..)))))).>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<.<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>..>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<.]]]..>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.....<<<<<<<..<<..<<<<....<<<........<<<<<..<<<<..>>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<........>>>>>>>>>>...>>>>..>>>..............>>>>..>>>>>>>>><<<<<....................<<.<<<<<<<.<<.....<<<<....<<<<<......>>>>>...>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..(((((((((((.....)))))).))))....))))....(((((((((....((((((((.((.....((((((((..({((((......)))))....[[(...).(((....}]])))...).))))))).))))))))))...)))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....((((((((((.(..(((((((.(((((.((....(((((.(((..(((((.(((((((((..)))))))))...))))))))))))))))))))))))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((...((((((......((((((((((........(((.(((((....))))).)))............)))))))))).......))))))...))).........))))))..))))))))))).....((.....{{))......((((((.(((((((.))))))).((((((..(((.(((((((....((((((..((..(.((((....)))).)...)).)))).))....)))).)))...)))...)))).))(((((.................)))))..[.)))))).....))).)))))...)))))...)))))))).<((((........))))((((((....(((((((((((((..(((..((((..........)))..)..)))...((....))...((((....(.........)...))))..(((((...(((..((.(]......[[[)))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......B)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((..........(((.((((((((.....((.....((.....((..(((((..(.....)..))))))).....))...))......))))))...(((((((((.(......))))))))))....))))))))))))..))..((((..(.((.....)).)..))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.....A.(((((.(((...((.........))...))).....(....(......)..).)))))...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((.......}}.........].]]......(...)........)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((..(((((((...((.....)).))))))....[[(((.((...(.....(((....)))...(.)....((.(((((((((...))))))))))).......)....))...(((((........)))))]]((((....(((((...(((((((....)))))))..((((....)))...(...((((((...((((((((((((((((((((((...{{{...)))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).))).))).....((......)).)))).((((.....))))..)))....(((......((((((..((..(....(.......(((((....(.[..).....)))))((.(((((((((((....)))))..)))))).))(...).......(((((((((.>.(...........)...(((((((....((((.....))))......))))))).].(.(.(((..((((((.(...(......((.(....).))......).)))))..)))))(.(.(.........).).)........((..........(((((.......)))))..)..)....).)....)).))))))).)..)))..))))))...)))))....)).[..((.((.....>].)).))....(((((..(((.((......((((.(((((...(((((.(((((((((.((((.(....((((((...........(((....(........)..............)))..))))))....)..))))...(((((.....(((....(.....(((..))).....)..............(((((.(((..(....(.(..)..)....)..))).)))))...)))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(..((....((....{..))....)).)(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}.....)))..)))))).......(....(.((((.(...((.......))...).))))...)....)........((((.((((((..(.(.(.(((......))).)...).).(((.(.....).))).....)))))..)...))).)......((((((....))).)))...b.))..))).))))).....(.((.(.(..(((..(.(((((......(....).....))))).)(((.....((((....((.(((((((}}}.)))))..)).))...))))....))).(((....((((.....a.......))))....)))..)))...).).)).).....(((((((..((..((((.(..(((.........((((..(((....))).))))........)))...(((..((((....((((.(((((..........)))))))))...))))..)))...........)..))))..)))))))))(((((....(.......).......((.(((((((.((.....(.((.(..(((((......)))))..))).)....))....)))).))).))..))))).. Rabbit 80S ribosome as it decodes the Sec-UGA codon; 28S rRNA 7zjw L7 119 2.8 RF00001 URS000231198C_9986 35709277 0003735 0005840 9986 ucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>... ((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))... Rabbit 80S ribosome as it decodes the Sec-UGA codon; 5S rRNA 7zjw L8 156 2.8 RF00002,RF02540 URS00023119A4_9986 35709277 0003735 0005840 9986 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauuncaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<<<<....>>>>.....<.<<<......>>.............>>>..>...>>>....<<....>><<<<<<<<<.....>>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))(((((((((.....))))))))).................... Rabbit 80S ribosome as it decodes the Sec-UGA codon; 5.8S rRNA 7zjw S2 1770 2.8 RF01960,RF02542,RF01959,RF00177 URS0002616B7D_9986 35709277 0003735 0005840 9986 uaccugguugauccugccaguagcaunugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucnuuaaaucaguuauggunccuunggucgcucguacuuggauaacugugguanuucuagngcuaananaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucagaucaaaaccaacccggugccggcggcuuuggugacucuagauaaccucgggccgaucgcacgcccuccguggcggcgacgacccauucgaacgucngcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgaunccggaganggagccugagaaacggcuaccacauncaaggnaggcagcaggcgcgcnaauuacccacucccgacccggggangungugangaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaanuccuuuaacgaggnuccauuggagngcaagucuggugccagcagccgcggnaauuccagcuccaauancguauauuaaaguugcugcaguunaaaagcucguaguungaucuugggagcgggcggccgcccguccccgccucucggcgccccggggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaaungaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagancgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacagganugacagauugauagcucuuucucgauuccguggguggngnugcauggcnguucuuaguugguggagcgauuugucugguuaauuccgauaacgancgagacunuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuncuuanagggacaaguggcguucagccacccgagauugagcaauaacangucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgagnaauucccaguaagugcgggucauaagcuugcguugauunagucccugcccuuuguacacaccgnccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggucggcccacggcccuggcggagcgcugagaagacggucgaacungacuaucuagaggaaguaaaagucguancaagguuucnguaggugnnccugcggaaggaucauua ...<<<<<...[[[[>>>>>[[[.((((((.....{{.........[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[......{{....[[[[[.........<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<...<....>...>>...>>>>[[..(((((.....<<<<<<<<..................<......>..)))))......]]...<<<<.<<<<......>>>>>>>>.]].]]]...}}....]]].<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<<...>>>>..>>>......}}.......<<<<<<<<<.<<<....>>>..>>>>>>.>>>......<<..<...........>..>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..)))))).]]]............{{.......{{...[[[.[[.....<........<..>........>.<<...<<<<.<<<<.>>.>>>>>>.>>..<<<<<<.<.......<<...<.......>.<<<<.......>>>>...>>......>.>>>..>>>........{.[[.(((((((......>>>>>>>>.))))))).]].}....]]....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<<....>>>>>>>>>>>.>..>>>...<<..}}>>...>>.....>>>.....<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<.......<<........>>..........<<<<<......<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<.......>>>>.>>>>.....>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.......>>>>>....>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<.<<<<<<<<<<<<.....>>>>>>>>>>>>...>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))((...(((((......(..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(....((....(((.....(([...((.....((.(((.....))).))......))......)).((((......................))))((..(((((......{.....{.(..........).....(......)..)))))......)).(]((((.((((......)))))))))...)))...))..).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)........(((((((((.(((....)))..)))))).)))....(.((..(...........)..))......)..((((([[....(.(.((.....((..]])).......)).)))))))..)))))...))..[......(.([[...(.(.((...(.(..(............................((...(((..((((.)).)).))).))..(..(((.(........(..((.......)).(((.......)))....).......).)))....)........(.((.(((((((.......}.....}.))))))).)).)....)....(((..(...(...(((...((..((((((((...(..........)......))))))))..)).......((....))....)))..)...)...))..)).)...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.(((((....))))))))))).)..)))...((..]]))...))...].))))).).(((......((.(....).))....)))...]]].]((((..(((((((..((..((.((..(((..(((((.......(........)...........(((((.(....(((((........(..(((........)))..)......)))))...((.(((...(.((((((.(..((..(((((....)))..(.((......)))...))..))....(((...(...((.(..(((((((((((((....).)))).)))).....))))..).))..).....(((((.....)))))........))).)..))).))).....).))))).....).)))))...)).)))..))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....((((............)))).....)..)..)).)).....((((((((.......))))))))......))...))))))).)).))..(.(..((.(..((((.((..(.((((((((.(((..((((.((.....((((((((((((((((.....)))))))))))).).))).....)).))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}........ Rabbit 80S ribosome as it decodes the Sec-UGA codon; 18S rRNA 7zjx I 163 3.1 RF00458 URS0002616B80_12136 35709277 0043022 12136 aaaaaugugaucuugcuuguaaauacaauuuugagagguuaauaaauuacaaguagugcuauuuuuguauuuagguuagcuauuuagcuuuacguuccaggaugccuaguggcagccccacaauauccaggaagcccucucugcggcuuuucaaccuugaggc ...<..........<..<<<<<...........(((..........>>>>>..>........>........(((...<<<<....>>>>.....<<<<..<....)))<<<<.....>>>>.....>..>>>>....)))....................... ....................((........................))........................[....((((....))))......((..(((....].(...........)....)))..))............................... Rabbit 80S ribosome programmed with SECIS and SBP2; CrPV IRES 7zjx L5 3732 3.1 RF02543 URS0002616B6F_9986 35709277 0003735 0005840 9986 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcgguggggcgcgggaaauguggcguacggaagacccacuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagngngaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcgugguccggccgugccggcggucucggcggaucuuucccgcuccggggucggcgggggaccgccccccggccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggccccggcggggaagguggcccggggggacgccucgccggcgggcgcgaccccuccccggguguuacagccccgccccggcagcagcagcucgccgaaucccggggccgagggagcgagaccugugucgccgcgcucuccccccucgggggggccgggccgccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgugucacgccgucgggcucgggggaggccacggcgcgucgcgcgccggcgcgcgcgcgcgagcgagcgcacggggucggcggcgaugucggcuacccacccgacccnucuugnaacncggaccaaggagunuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcggcggcgccgucgucggccgaggugggaucccgaggcccuuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccnanagauggugancuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauagnggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcaaccccgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcngaacuggcgnugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgcuggcagucggcagagcgagaaagagaguggagccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaunuuggugguagunnnaaauauucaaacgagaacuuugaaggccgaaguggngaaggguuccaugngaacagnanuugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucagccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccnuauccgcagcaggucuncaaggugaacngccucuggnauguuggaacaanguagguaagggaagucggcaagcnggauccguaacuucnggauaaggauuggcucuaagggcugguagcagccgacuuagaacuggugcggaccaggngaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugccnagugcucugaaugucanagugangaaauucaaugaagcgcggnuaaacggcgggaguancuaugacucucuuaagguagcnaanugccucnucaucuaauuagugangcgcaugaauggaugancgagnuucccacugunccuaccuacuauccagcgaaaccacngncaagggaacgggcuuggnggaaucagcggngaaagaagacccuguugagcuugacncuagucuggcacggugaanagacaugagagguguagaauaagugggaggcccgggccgccggugaaauaccacuacucuuaucguuuuuucacugacccggugaggcgggggggcgagccccgaggggcucucgcuucuggcgccaagcgccgggccccgucgguccgggccggcggcggccgggcgcgacccgcuccggggacagugccagguggggaguuugacugnggcgguacaccugucaaacgguancgcaggnnuccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucagnacgaauacagaccgugaaagcggggccucacgauccuucugagcuuuuggguuuuaagcaggangugucagaaaaguuaccacagngauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuungaugucggnucuuccuaucauugugaagcagaauucaccaagcguungaunnuucacccacuaauagggaacgugngcugggnuuagancgucgugagacagguuaguuuuacccuacugaugnuguguuguugccaugguanuccugcucaguacgagaggaaccgcagnuncanacauuugguguaunugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgaaggagccucgguuggccucggauagccggucccccgcgggguccggugcggagagcccuucgucccgggaaauggggcgcggccggaaagggggccgcccucucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>>..<<<<<<<<<....<<<<<<<<.<<<....<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>>>>>>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<<....<<<<<<<.<<<<<.<.....<<<<<.<<<..<<<<.<.........>>>>>>>>>>>>>.>>>>>>>>>>...>>>.>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<.<<<<<<<<<<.<<<<...<<..<<<..<<<<<<<......<<<<.<<<<<.......<....>...........>>.>>>>>>>.......>>>>>>>..>>>.........>>>>>>...>>>>>>>>>>.....<<.....[[>>......<<<<<..<<<<<<<.>>>>>>>...<<<<.<<<<.<<<<<<<<<.<<<<<<.....<<<.<<<<....>>>>.>>>.....>>>.>>>.>>>>>>.>>>...>>>>..>>>>...<<<....<<..........>>...>>>.....>>>>>......>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<<<<...<<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<<<.<<..>>.>>>>>>>>>..<<<<<...<<<..<<....{{...{{..>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>>.<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<..........<<<.<<<<<<<<<...<<<....<<<..<.<<<..<<<<<<.<.....>.>>>>>>>>>.>..>>>..>>.>...>>>>>>>...<<<<<<<<<.........>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<..<....<<.........>>....>..........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<.......]]...........}}...}}..............>>>>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<<<<<...>>>>>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<..<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<...............<<<<<....<....>.....>>>>><<.<<<<<<<<<<<....>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<..<<<<<<<<<.<<<<<<.<<<<<<<<<...........<<<<<..<<<<..>>>>............>>>>>..>>>>>>.>>>.>>>>>>...<<<<<.....<<<<.....<<<<<<....>>>>>>................<<<<<..<<...<<...<<..>>...>>....>>..>>>>>..>>>>..>>>>>....>>>>>>>>>...>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>><<<<....>>>>>>)))].....<<<<<<<..<<<..)))))).>>>>>>>>>>.........>>>>..>>>>>>.......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<]]].>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.....<<<<<<<..<<..<<<<....<<<........<<<<<..<<<<..>>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<..........>>>>>>>>>...>>>>..>>>..............>>>>..>>>>>>>>><<<<<....................<<.<<<<<<<.<<.....<<<<.<..<<<<<......>>>>>..>>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..(((((((((((.....)))))).))))....))))....(((((((((....((((((((.((.....((((((((..({((((......)))))....[[(...).(((....}]])))...).))))))).))))))))))...)))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....((((((((((.(..(((((((.(((((.((....(((((.(((.......((.......))....)))))))))))))))))))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((..(((((((......((((..((.............................)).)))).......)))))))..))).........))))))..))))))))))).....((.....[[))......((((((.(((((((.)))))))...((((..(((.(((((((((...........((...((((....))))....))...........)))))).)))...)))...))))...((.......................))..[.)))))).....))).)))))...)))))...)))))))).<((((........))))((((((....(((((((((((((..(((..((((..........)))..)..)))...((....))...(((((((...((()))...)))))))..(((((...(((..((.(].......{{)))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((..........(((.((((((((.....((.....((.....((..((((((.(.....).)))))))).....))...))......))))))...(((((((((.(......))))))))))....))))))))))))..))..((((..(.((.....)).)..))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.......(((...(((...................))).........((......)).....)))...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((.......]].........}.}.......(...)........)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((..(((((((...((.....)).))))))....[[(((.((...(.....(((....)))...(.)....((.(((((((((...))))))))))).......)....))...(((((........)))))]]((((....(((((...((.((((....)))).))..((((....)))...(...((((((...((((((((((((((((((((((....{{...)))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).))).))).....((......)).)))).((((.....))))..)))....(((......((((((..((..(....(.......(((((....(.[..).....)))))((.(((((((((((....)))))..)))))).))(...).......(((((((((.>.(...........)...(((((((....((((.....))))......))))))).].(.(.(((..((((((.(...(......((.(....).))......).)))))..)))))(.(.(.........).).)........((..........(((((.......)))))..)..)....).)....)).))))))).)..)))..))))))...)))))....)).[..((.((.....>].)).))....(((((..(((.((......((((.(((((...(((((.(((((((((.(((((((((((((((...............((..(((....)))............))......))))).))))))))))...(((((.....(((....(.....(((..).))....)..............(((((..(...(.................)....).)))))...)))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(..((.(..((....{..))...))).)(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}.....)))..)))))).......(....(.((((.(...((.......))...).))))...)....)........((((.((((((..(.(.(.(((......))).)...).).(((.(.....).))).....)))))..)...))).)......((((((....))).)))...a.))..))).))))).....(.((.(.(..(((..(.(((((......(....).....))))).)(((.....((((....((.(((((((}}..)))))..)).))...))))....))).((((...((((.............))))...))))..)))...).).)).).....(((((((..((..((((.(..(((.........((((..((((())))).))))........)))...(((..((((....(..(...((((........))))..)...)..))))..)))...........)..))))..)))))))))(((((....(.......).......((.(((((((.((.....(.((.(..(((((......)))))..))).)....))....)))).))).))..))))).. Rabbit 80S ribosome programmed with SECIS and SBP2; 28S rRNA 7zjx L7 120 3.1 RF00001 URS000002B0D5_9986 35709277 0003735 0005840 9986 nucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. Rabbit 80S ribosome programmed with SECIS and SBP2; 5S rRNA 7zjx L8 156 3.1 RF00002,RF02540 URS00023119A4_9986 35709277 0003735 0005840 9986 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauuncaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<<<<....>>>>.....<.<<<......>>.............>>>..>...>>>....<<....>><<<<<<<<<.....>>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))(((((((((.....))))))))).................... Rabbit 80S ribosome programmed with SECIS and SBP2; 5.8S rRNA 7zjx S 46 3.1 RF00031 URS0002616B65_10116 35709277 0001514 10116 caugacggucugccugaaaaccagcccgcugguggggcagucccga ......<..<<<<......<<.<......>.>>...>>>>..>... ..........(..........(.........).......)...... Rabbit 80S ribosome programmed with SECIS and SBP2; GPX4 SECIS element 7zjx S2 1770 3.1 RF01960,RF02542,RF01959,RF00177 URS0002616B7D_9986 35709277 0003735 0005840 9986 uaccugguugauccugccaguagcaunugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucnuuaaaucaguuauggunccuunggucgcucguacuuggauaacugugguanuucuagngcuaananaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucagaucaaaaccaacccggugccggcggcuuuggugacucuagauaaccucgggccgaucgcacgcccuccguggcggcgacgacccauucgaacgucngcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgaunccggaganggagccugagaaacggcuaccacauncaaggnaggcagcaggcgcgcnaauuacccacucccgacccggggangungugangaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaanuccuuuaacgaggnuccauuggagngcaagucuggugccagcagccgcggnaauuccagcuccaauancguauauuaaaguugcugcaguunaaaagcucguaguungaucuugggagcgggcggccgcccguccccgccucucggcgccccggggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaaungaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagancgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacagganugacagauugauagcucuuucucgauuccguggguggngnugcauggcnguucuuaguugguggagcgauuugucugguuaauuccgauaacgancgagacunuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuncuuanagggacaaguggcguucagccacccgagauugagcaauaacangucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgagnaauucccaguaagugcgggucauaagcuugcguugauunagucccugcccuuuguacacaccgnccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggucggcccacggcccuggcggagcgcugagaagacggucgaacungacuaucuagaggaaguaaaagucguancaagguuucnguaggugnnccugcggaaggaucauua ...<<<<<...[[[[>>>>>[[[.((((((.....{{.........[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[......{{....[[[[[.........<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<<<....>>>>>>...>>>>[[..(((((.....<<<<<<<<.<<<....>>>.......<......>..)))))......]]...<<<<.<<<<......>>>>>>>>.]].]]]...}}....]]].<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<<...>>>>..>>>......}}.......<<<<<<<<<.<<<....>>>..>>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..)))))).]]]............{{.......{{...[[[.[[.....<<.<<<<<<....>>>>>>.>>.<<...<<<<..<<.<>>>..>>>>.>>..<<<<<<.<.......<<...<.......>.<<<<.......>>>>...>>......>.>>>..>>>........{.[[.(((((((......>>>>>>>>.))))))).]].}....]]....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<<....>>>>>>>>>>>.>..>>>...<<..}}>>...>>.....>>>.....<<<......<<<......>>>....>>>..]]]]..<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<.......<<........>>..........<<<<<......<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<.......>>>>.>>>>.....>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.......>>>>>....>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>............<<<<<..........>>>>>...........>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<<<<<<<<<<<<<<.....>>>>>>>>>>>>.>.>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))((...(((((......(..((.....(((.(((..((....((....((..........))...)){))......(((.......(((.(.(..((....(((((...(({...((.....((.(((.....))).))......))......)).(.........(.........)........)((..(((((.....[[.[[[[[..(......)........(......)..)))))......)).(}((((.((((......))))))))))).)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)...)........(((((((((.(((....)))..)))))).)))....(.((..(...........)..))......)..((((([[....(.(.((.....((..]])).......)).)))))))..)))))...))..{......(.({{...(.(.((...(.(..(....(((..................)))..(...(((...........)))..)...(..(((.(........(..((.......)).((((...)..)))....).......).)))....)........(.((.(((((((......]]]]].]].))))))).)).)....)....(((..(...(...(((...((..((((((((...(..........)......))))))))..)).......((....))....)))..)...)...))..)).)...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..(.((((((.(((((....))))))))))).)..)))...((..}}))...))...}.))))).).(((......((.(....).))....)))...]]].]((((..(((((((..((..((.((..(((..(((((.......(........)...........(((((.(....(((((.....(..(..(((........)))..)....).)))))...((.(((...(.((((((....((..(((((....)))..(.((......)))...))..))....(((...(...((.(..(((((((((((((....).)))).)))).....))))..).))..).....(((((.....)))))........)))....))).))).....).))))).....).)))))...)).)))..))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....((((............)))).....)..)..)).)).....((((((((.......))))))))......))...))))))).)).))..(.(..((.(..((((.((..(.((((((((.(((..((((.((...((((((.(((((((((((.....)))))))))))..).)))))...)).))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>........ Rabbit 80S ribosome programmed with SECIS and SBP2; 18S rRNA 7zlq C 13 2.8 URS00029156DB_32630 32630 cgaagccuucgcg ............. ............. Crystal structure of ADAR1-dsRBD3 dimer in complex with dsRNA; RNA (5'-R(*CP*GP*AP*AP*GP*CP*CP*UP*UP*CP*GP*CP*G)-3') 7zlq D 13 2.8 URS00029156DB_32630 32630 cgaagccuucgcg ............. ............. Crystal structure of ADAR1-dsRBD3 dimer in complex with dsRNA; RNA (5'-R(*CP*GP*AP*AP*GP*CP*CP*UP*UP*CP*GP*CP*G)-3') 7zlq E 13 2.8 URS00029156DB_32630 32630 cgaagccuucgcg ............. ............. Crystal structure of ADAR1-dsRBD3 dimer in complex with dsRNA; RNA (5'-R(*CP*GP*AP*AP*GP*CP*CP*UP*UP*CP*GP*CP*G)-3') 7zod a 118 2.56 RF00001 URS0000049E57_562 35869078 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))). 70S E. coli ribosome with an extended uL23 loop from Candidatus marinimicrobia; 5S rRNA 7zod b 2901 2.56 RF02541 URS0000311517_562 35869078 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaagcgacuugcucguggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuagaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaagggugaugcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaac <.<..<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<<..>>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<..................>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<.....<.....................>..........<........>......>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<........>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<.......>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.......<<<<<<.<<....>>..>>>>>>.......>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<....................................................................................>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<..<<.....>>..>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<<...>>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>.>.> (.(...((......((((((((((.....(((..(((((((((((((......((((((.[.[.[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))..(((((((...(((((((((.....(((...(((.((((...(..................)...)))).)))..)).).....)))))).)))...))))))).....((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.((......(...(...........)...)..........(..........).....))...)))..))))).))...........]]].)...))))))))))...)))))))(((((((........)))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((..((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((........)))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((..(..)]..))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((((..((....................................................................................))..))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..)))....((.....))........)))))..)...))).))....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((...))))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).)))..).) 70S E. coli ribosome with an extended uL23 loop from Candidatus marinimicrobia; 23S rRNA 7zod v 77 2.56 RF00005 URS00001DEEBE_562 35869078 0030533 0006412 562 cggugauuggcgcagccugguagcgcacuucguucgggacgaaggggucggagguucgaauccucuaucaccgacca ..<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>...... ..(((((...(((......[..)))..((((.........)))).....(((((..]....))))))))))...... 70S E. coli ribosome with an extended uL23 loop from Candidatus marinimicrobia; Pro-tRNA 7zp8 a 118 2.2 RF00001 URS0000049E57_562 35869078 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))). 70S E. coli ribosome with a stalled filamin domain 5 nascent chain; 5S rRNA 7zp8 b 2901 2.2 RF02541 URS0000311517_562 35869078 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaagcgacuugcucguggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuagaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaagggugaugcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaac .<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<................>>...>>>>.>>>..>>.>.....>>>>>>>.>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<......<.....................>.........<<<......>>>......>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<........>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<..<<....>>...>>>>>........>>>>>>>>..>>>>><<<<<.........>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<..................................................................................>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<.<<<.....>>.>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>> .(((((((......((((((((((.....(((..(((((((((((((......((((((.[...[[.))).....((((((...(((]]...].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....(((((((((..((((...((((((......))))))...)[)))...(((.(((((........))))))))....))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((...(((((((((.....(((...(((.((((...(((.(.........).).))...)))).)))..)).).....))))))).))...))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(.......(...(...........)...)..........(((......)))......)...)))..))))).))...........]]].)...))))))))))...)))))))(((((((........)))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((..((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))(...((((...((((((((((((.((.....))))))))))..))))..[))))....)(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((..................................(................)..............................)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((]..[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].......(((((((.((..]]]]..))))))))).....)}......))))..)))))).......((((.(.((((((...((.......))...))))))...)))).).......(((((.((((((..(((((((((......))))))..)))....((.....))........)))))..)...))).))....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).)))))))) 70S E. coli ribosome with a stalled filamin domain 5 nascent chain; 23S rRNA 7zp8 v 76 2.2 RF00005 URS00001DEEBE_562 35869078 0030533 0006412 562 ggugauuggcgcagccugguagcgcacuucguucgggacgaaggggucggagguucgaauccucuaucaccgacca ..........<.............>.<<<<<.......>>>>>.....<<<<<.......>>>>>........... .(....(...........[.......((((.........)))).....(((((..]....))))))....)..... 70S E. coli ribosome with a stalled filamin domain 5 nascent chain; Pro-tRNA 7zpq 2 1771 3.47 RF01960,RF02542,RF01959,RF00177 URS0001A16A88_4932 36801861 0003735 0005840 4932 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugagcuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauu ...<<<<<.{.((((>>>>><<<<.<<<<<<...<.<...<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<..<<..<<....<<<..................<<....<<.<<.......>>.>>.....>>.........<<<<<..<<....>>..>>>>><.<.<<<<<<......(((.{((.<.<....>.>..............>>>>>>.>...>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>..>>>..>....>.>.....<<<<<<<<<<<<<....>>>>>>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>>.........<<<[[.....<.<<...<<<.<<....<<<<<<.<<<<..............>>>>.>>>>>>.....<<<<<....................>>>>>....<<<<<.<<.......<<...<.......>..<<<<...>>>>....>>......>>.>>..>>>.........<<...<<<<<<<<.....)).}))).>>>>>>>>..>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..]]>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..)))).}<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>......<....<<<<<<..........>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<.<<<<.<<<<....>>>>.>>>>.>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>........ ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[[.[[[.(.(....).).....(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(((((((.(.(((....))).).)))).)))....(.(((.(...........)).))......)..((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((.....(.....)....))).)))))).....(((((....................)))).)...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(....(.((.((......]].]]]]..)).)).)...).....))...(((..((.((...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)).))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].].((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((.(..(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..))))).)..))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).)...(.(..((.(..((((.((..(.((((((((.(((..(.((..(...((((((..((((.((((....)))).))))..))))))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>....... Structure of the RQT-bound 80S ribosome from S. cerevisiae (C1); 18S ribosomal RNA 7zpq 3 158 3.47 RF00002 URS00001BF64E_4932 36801861 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Structure of the RQT-bound 80S ribosome from S. cerevisiae (C1); 5.8S ribosomal RNA 7zpq 4 121 3.47 RF00001 URS000055688D_4932 36801861 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Structure of the RQT-bound 80S ribosome from S. cerevisiae (C1); 5S ribosomal RNA 7zpq 5 3184 3.47 RF02543 URS000061F377_4932 36801861 0003735 0005840 4932 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........................<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..<<<..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<.<<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<.........................<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<......>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<....<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>..>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<...<.....>....>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<.<.....<<<....>>>.....{.<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..[[[..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>.>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<....>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.....<<.....<<<<....>>>>.....>>..>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<..<<<<<<<<<<<<<<<<<....>>>>>>>.>>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...........}...<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))......<<<<<<<..<<<<.))))))>>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>........<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>.....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<....<<<<<<<<<<]]].>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<.<..<<<<<......>>>>>..>>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((.((((((.((((((((...({((((......)))))[[(...).(((....}]])))....))))))))...)))))).....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.(((((.........................(((((((((((((((((((((((.......(((((((......((((........)))).......))))))).....))))).))))))))))........(((....)))....)))))))).....))))).))))).[((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((((((((((....((.(((((((.....(((....(((..(.((((....(((((.....)))))..)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((.(.(((...((.........))...))).........((......))....))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........((.((.((...))...))))....))....))...(((((........)))))]]((((..(((...(...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....).....))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((....)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.((.(((.((....)).)))..)).)))))))....((((.....((((..((((........))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Structure of the RQT-bound 80S ribosome from S. cerevisiae (C1); 25S ribosomal RNA 7zpq 6 76 3.47 RF00005 URS00023119BF_4932 36801861 0030533 0006412 4932 uuccucguggcccaauggucacggcgucuggcuucgaaccagaagauuccagguucaaguccuggcggggaagcca <<<<<<<..<<<..........>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... ((((.((..(((.....[....))).(((((.......))))).....(((((..]....))))))).)))).... Structure of the RQT-bound 80S ribosome from S. cerevisiae (C1); tRNA 7zq5 a 118 2.7 RF00001 URS0000049E57_562 35869078 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))). 70S E. coli ribosome with truncated uL23 and uL24 loops; 5S rRNA 7zq5 b 2900 2.7 RF02541 URS0000311517_562 35869078 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccgacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaagcgacuugcucguggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuagaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaagggugaugcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaac .<<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<...<<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>>.<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<................>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<.......<<.........<<...........>>..............<........>......>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<........>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<..................................................................................>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<..<<.....>>..>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>> .(((((((......((((((((((.....(((..(((((((((((((......((((((.[...[[.))).....((((((...(((]]...].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((.(((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))))))).)))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((...(((((((((.....(((...(((.((((...((..(.........)...))...)))).)))..)).).....)))))).)))...))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((....{.((......(...(...........)...)..........(..........).....))...)))..))))).))...........]]].)...))))))))))...)))))))(((((((........)))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((..((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.................(................(................).....................)........)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..)))....((.....))........)))))..)...))).))....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).)))))))) 70S E. coli ribosome with truncated uL23 and uL24 loops; 23S rRNA 7zq6 a 118 2.75 RF00001 URS0000049E57_562 35869078 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))). 70S E. coli ribosome with truncated uL23 and uL24 loops and a stalled filamin domain 5 nascent chain; 5S rRNA 7zq6 b 2901 2.75 RF02541 URS0000311517_562 35869078 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaagcgacuugcucguggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuagaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaagggugaugcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaac .<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<................>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<.....<...<.<.........>.>...>..........<<......>>......>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<........>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<<.<<....>>..>>>>>>..>....>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<..................................................................................>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<..<<.....>>..>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<<...>>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>> .(((((((......((((((((((.....(((..(((((((((((((......((((((.[....[.))).....((((((...(((]....].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((...(((((((((.....(((...(((.((((...(((.(.........).).))...)))).)))..)).).....)))))).)))...))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.((..........(...........)..............(.(......).).....))...)))..))))).))...........]]].)...))))))))))...)))))))(((((((........)))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((..((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((.(.................(.......................................................)........).)))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..)))....((.....))........)))))..)...))).))....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((...))))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).)))))))) 70S E. coli ribosome with truncated uL23 and uL24 loops and a stalled filamin domain 5 nascent chain; 23S rRNA 7zq6 M 76 2.75 RF00005 URS00001ACE3E_562 35869078 0030533 0006412 562 gcgggaauagcucaguugguagagcacgaccuugccaaggucggggucgcgaguucgagucucguuucccgcucca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).(((((.......))))).....(((((..]....)))))))))))).... 70S E. coli ribosome with truncated uL23 and uL24 loops and a stalled filamin domain 5 nascent chain; Gly-tRNA 7zrs 2 1771 4.8 RF01960,RF02542,RF01959,RF00177 URS0001A16A88_4932 36801861 0003735 0005840 4932 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Structure of the RQT-bound 80S ribosome from S. cerevisiae (C2) - composite map; 18S ribosomal RNA 7zrs 3 158 4.8 RF00002 URS00001BF64E_4932 36801861 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Structure of the RQT-bound 80S ribosome from S. cerevisiae (C2) - composite map; 5.8S ribosomal RNA 7zrs 4 121 4.8 RF00001 URS000055688D_4932 36801861 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<<............>>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Structure of the RQT-bound 80S ribosome from S. cerevisiae (C2) - composite map; 5S ribosomal RNA 7zrs 5 3185 4.8 RF02543 URS000061F377_4932 36801861 0003735 0005840 4932 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Structure of the RQT-bound 80S ribosome from S. cerevisiae (C2) - composite map; 25S ribosomal RNA 7zrs 6 75 4.8 RF00005 URS0000E60BA3_4932 36801861 0030533 0006412 4932 uccgauauagcguaacggcuaucacaucacgcuuucaccguggagaccgggguucgacuccccguaucggagcca <<<<<<<..<.<..........>.>.<<<<<.......>>>>>....<<<<<.......>>>>>>>>>>>>.... (((((((..(.(.....[....).).(((((.......)))))....(((((..]....)))))))))))).... Structure of the RQT-bound 80S ribosome from S. cerevisiae (C2) - composite map; tRNA 7zs5 1 3248 3.2 RF02543 URS000061F377_4932 36801861 0003735 0005840 4932 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaugguguuuuguaaucucgcauuucacugggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguagugagggccuuggucagacgcuuguuguagacggccuuggucuugcuacaauuaacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauagagggcuaccuuuauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<<....>>......>>>>>.>...<.....<<....>>..<<<<<......<<.....>>.....>>>>>..<<<...........<<.<<<<<<...>>>>>>.>>.............<<<<<<.<<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.((......<<<.....))>>>..>.>>>>>>>>>..>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>....>.............................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<......<<<....<<........>>....>>>..<<<<<<<<<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>>..>.>>>>>.>>>>>>>>>>........<<<....>>>....>>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<......>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<<..<<<<<<.....>>>>>>>>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<........<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>....>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>>..<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<.<<<........>.>>>>....>>....>>>..<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>...<.{{<<<<<<...<<<<.<<<<<<<<<<<<<<<<<<..[[[..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<<....>>>>>>>>>>>>.>.>>>>>>>.>>>>.........>>>>>>...>......>>>..>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<<........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<.<<<<<<........<<<.....<.......>.....>>>.......>>>>>>......>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.....<<.....<<<<....>>>>.....>>..>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>.>>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<..<<.<<<<<<<<<<<<<......>>>>>>.>>>>>>>.>>...<<<<<.....<<<<..<<<<<......>>>>>..........}}...<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))......<<<<<<<..<<<<.))))))>>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<<...<<<<<<<<<<]]].>>>>>..>>>>>..>>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<.<..<<<<<......>>>>>..>>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((.(((((((((((.(.(...({((((......)))))[[(...).(((....}]])))....).).))))..))))))).....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((......(.(...((........))...).)...(((((((((((((((((((((((.......(((((((......((((........)))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...(......).......(((((..(((((....)))))...))))).((((((((..............))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((........)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.(((.(...(((((.....)))))..)))).)..)))..)).).....)))))...((((..(((.(......))))..)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.(((((((((......{.(((((.(((...((.........))...))).....(...((......)).).)))))....))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........(..(.(........)..).)....))....))....((((........)))).]]((((.((((...(...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....).((((((......)))))).)))).).))))))).))))(...)....))))))...))....).....)))))))).)))..)).....((......)).)))).((((.....))))..)))...((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((.(((.((((..((......((.....................)).....))..))))......))).)..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.....((.....((((....)))).....))..))))..))))).((((.........)))).........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.((((((((......)))))).)).)))))))...(((((.....((((..((((........))))...........>...((((((....))))))..))))..))))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(...((((((...((.......))...))))))....).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))....))..))).))))).....(((((((..((((.(.(((((......(....).....))))).)((((....((((....((((((((((}}..)))))..)))))...))))...)))).((((...((((.....}.......))))...)))).))))....)))))))........(.((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((.(.(..(((......)))..).).))).)))))).............)).))).)))).)..(((((.(..(.......)..)...(.(((((((((.((.....((((.(..((((((..)..)))))..)))))....))....)))).)))))).))))).. Structure of 60S ribosomal subunit from S. cerevisiae with eIF6 and tRNA; 25S ribosomal RNA 7zs5 3 121 3.2 RF00001 URS000055688D_4932 36801861 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).)).(((((.......(((((..((....)).))))).....))))).))))))))). Structure of 60S ribosomal subunit from S. cerevisiae with eIF6 and tRNA; 5S ribosomal RNA 7zs5 4 158 3.2 RF00002 URS00001BF64E_4932 36801861 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<(.....>>............).>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Structure of 60S ribosomal subunit from S. cerevisiae with eIF6 and tRNA; 5.8S ribosomal RNA 7zs5 2 76 3.2 RF00005 URS00023119BF_4932 36801861 0030533 0006412 4932 uuccucguggcccaauggucacggcgucuggcuucgaaccagaagauuccagguucaaguccuggcggggaagcca <<<<<<<..<<<..........>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..(((.....[....))).(((((.......))))).....(((((..]....)))))))))))).... Structure of 60S ribosomal subunit from S. cerevisiae with eIF6 and tRNA; tRNA 7zta 16S1 1534 2.7 RF00177,RF01959,RF02542,RF01960 URS000081169C_83333 37322159 0003735 0005840 83333 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<......>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((.(....).))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((...(....).)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((.(...(..(.((((((((.......)))))))).)...)....).)))....)..(((.([[[...(((((.....((.]]])).......)))))).)))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((..(((((((....)))))))....(....)...))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....))))))))..)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Structure of an Escherichia coli 70S ribosome stalled by Tetracenomycin X during translation of an MAAAPQK(C) peptide; 16S ribosomal RNA 7zta 23S1 2903 2.7 RF02541 URS000080E25C_83333 37322159 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<<.....>>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<<..<<<<.......>>>>..>>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<......>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>.>......>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((((.........))).))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.......(((((.(((..(((.........)))..))).....(...((......)).).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((((......))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((((.(......[..(((((..(((.......((.((((....)))).))....)))..........].)))))).)))).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Structure of an Escherichia coli 70S ribosome stalled by Tetracenomycin X during translation of an MAAAPQK(C) peptide; 23S ribosomal RNA 7zta 05S1 120 2.7 RF00001 URS0000049E57_83333 37322159 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Structure of an Escherichia coli 70S ribosome stalled by Tetracenomycin X during translation of an MAAAPQK(C) peptide; 5S ribosomal RNA 7zta ATR1 68 2.7 URS000003E908_83333 37322159 0030533 0006412 83333 ggcgcgunaacaaagcggauguagcggauugcanauccgucuaguccggnugacuccggaacgcgccu <<<<<<<..<<<.......>>>.<<<<<<.....>>>>>>....<<<<<......>>>>>>>>>>>>. (((((((..(((.......))).((((.........))))....(((((......)))))))))))). Structure of an Escherichia coli 70S ribosome stalled by Tetracenomycin X during translation of an MAAAPQK(C) peptide; tRNA-Cys 7zta PTR1 73 2.7 RF00005 URS000042DDAB_83333 37322159 0030533 0006412 83333 gggucguuagcucagggnagagcaguugacunuunaucaauugncgcaggnucgaauccugcacgacccacca <<<<<<<..<<<<......>>>>.<<<<<.......>>>>>....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[..))))(((((.........)))))...(((((..]....)))))))))))).... Structure of an Escherichia coli 70S ribosome stalled by Tetracenomycin X during translation of an MAAAPQK(C) peptide; tRNA-Lys 7zta ETR1 68 2.7 RF00005 URS00004FF598_83333 37322159 0030533 0006412 83333 ugggguancgccaagngaaggcaccgganucugnuuccggcauccgaggnucgaauccucguacccag <.<<<<<..<<<.......>>>.<<<<<.......>>>>>....<<<<<.......>>>>>>>>>>>. (.(((((..(((....[..))).((((.........))))....(((((..]....))))))))))). Structure of an Escherichia coli 70S ribosome stalled by Tetracenomycin X during translation of an MAAAPQK(C) peptide; tRNA-Gln 7zta MRN1 14 2.7 37322159 83333 cagaagugugcagc .............. .............. Structure of an Escherichia coli 70S ribosome stalled by Tetracenomycin X during translation of an MAAAPQK(C) peptide; mRNA 7zuw 2 1771 4.3 RF01960,RF02542,RF01959,RF00177 URS00005F2C2D_4932 36801861 0003735 0005840 4932 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugagcuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauu ...<<<<<.{.((((>>>>><<<<.<<<<<<...<.<...<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<..<<..<<....<<<..................<<....<<.<<<.....>>>.>>.....>>.........<<<<<..<......>..>>>>><.<.<<<<<<......(((.(((.<.<....>.>....<<......>>>>>>>>.>...>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<<..>>>.>...>>>>>>.........<<<....<<<.....>>>..>>>..>....>.>.....<<<<<<<.<<<<<....>>>>>.>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>>.........<<<[[.....<.<<...<<<.<<....<<<<<<.<<<<..............>>>>.>>>>>>......<<<<....................>>>>.....<<<<<.<<.......<<...<.......>..<<<<...>>>>....>>......>>.>>..>>>.........<<...<<<<<<<<.....))).))).>>>>>>>>..>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..]]>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..)))).}<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>......<....<<<<<<..........>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<.<<<<.<<<<....>>>>.>>>>.>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>........ ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((.....(..........)....)){))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[[.[[[.(.(....).).....(......).)))))).)...).(.((((.(((((..).)))))))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(.(((((.(.(((....))).).)))).).)....(.(((.(...........)).))......)..((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((................))).))))))....(.((((....................)))).)...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(....(.((.((......]].]]]]..)).)).)...).....))...(((..((.((...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)).))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].].((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((.(..(((.(((((....)))..(.((......)))...)).)))....(((.(.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..).))).)..))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).)...(.(..((.(..((((.((..(..(((((((.(((..(.((..(...((((((..((((.((((....)))).))))..))))))...)..)).)..))).))))))).)..)).))))...).))...)..)..(((((((((....)))))))))>....... Structure of RQT (C1) bound to the stalled ribosome in a disome unit from S. cerevisiae; 18S ribosomal RNA 7zuw 3 158 4.3 RF00002 URS00001BF64E_4932 36801861 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Structure of RQT (C1) bound to the stalled ribosome in a disome unit from S. cerevisiae; 5.8S ribosomal RNA 7zuw 4 121 4.3 RF00001 URS000055688D_4932 36801861 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Structure of RQT (C1) bound to the stalled ribosome in a disome unit from S. cerevisiae; 5S ribosomal RNA 7zuw 5 3163 4.3 RF02543 URS000061F377_4932 36801861 0003735 0005840 4932 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Structure of RQT (C1) bound to the stalled ribosome in a disome unit from S. cerevisiae; 25S ribosomal RNA 7zuw 6 76 4.3 RF00005 URS00023119BF_4932 36801861 0030533 0006412 4932 uuccucguggcccaauggucacggcgucuggcuucgaaccagaagauuccagguucaaguccuggcggggaagcca <<<<<<<..<<<..........>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... ((((.((..(((.....[....))).(((((.......))))).....(((((..]....))))))).)))).... Structure of RQT (C1) bound to the stalled ribosome in a disome unit from S. cerevisiae; tRNA 7zux 2 1769 2.5 RF01960,RF02542,RF01959,RF00177 URS00005F2C2D_4932 36801861 0003735 0005840 4932 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Collided ribosome in a disome unit from S. cerevisiae; 18S ribosomal RNA 7zux 3 158 2.5 RF00002 URS00001BF64E_4932 36801861 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Collided ribosome in a disome unit from S. cerevisiae; 5.8S ribosomal RNA 7zux 4 121 2.5 RF00001 URS000055688D_4932 36801861 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Collided ribosome in a disome unit from S. cerevisiae; 5S ribosomal RNA 7zux 5 3163 2.5 RF02543 URS000061F377_4932 36801861 0003735 0005840 4932 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........................<<<<<<.....<......>......>>>>>.>...{.....<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<........<<.<<<<<<...>>>>>>.>>........>....<<<<<<.<<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]....}.............................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<....<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<......>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<....<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>..>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>>..<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<<<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>.>.>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<....>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.....<<....<<<<<....>>>>.>...>>..>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<<<<<<<<<....>>>>>>>.>>>>>>>>>>...<<<<<.....<<<<..<<<<........>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>..>>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<.<..<<<<<......>>>>>..>>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.(((((....(((((((((((((((((((((((.......(((((((......((((........)))).......))))))).....))))).))))))))))........(((....)))....)))))))).....))))).))))).<((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((....((.(((((((.....(((....(((..(.((((....(((((.....)))))..)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((.(.(((....(.........)....))).........((......))....))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........((.(.((.....).)..)))....))....))...(((((........)))))]]((((..(((((((...((((....)))...(.[[((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((....)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(...((.....((((....)))).....)).)))))..))))).((((.........)))).........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((((((((.(((....))).))).))))))))))...(((((.....((((..((((........))))..........]]...((((((....))))))..))))..))))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(((.((..)..).)))..)))))...)))....)))).)))))).))))).. Collided ribosome in a disome unit from S. cerevisiae; 25S ribosomal RNA 7zux 6 76 2.5 RF00005 URS00008FED3A_4932 36801861 0030533 0006412 4932 gcccggauagcucagucgguagagcaggggauuaggaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... ..(((.(..((((........)))).(((((.......))))).....((.(.........).))).)))...... Collided ribosome in a disome unit from S. cerevisiae; A/P tRNA 7zux 7 77 2.5 RF00005 URS000041AF00_4932 36801861 0030533 0006412 4932 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(.(((..]....))).)))))))..... Collided ribosome in a disome unit from S. cerevisiae; P/E tRNA 7zw0 LA 3217 2.4 RF02543 URS000061F377_580240 36113412 0003735 0005840 580240 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........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<.<<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<.........................<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<....<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>..>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<......<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>....>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<..<.....>...>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<<....>>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<.<<<<<<<<<<<....>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.....<<.....<<<<....>>>>.....>>..>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<<....<<<...........<<<<......................>>>>..>>>.....>>>>>>>>>>...<<<<<.....<<<<..<<<<..>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<<...<<<<<<<<<<}}}.>>>>>..>>>>>..>>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<.<..<<<<<......>>>>>..>>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.(((((.......(...............).(((((((((((((((((((((((.......(((((((......((((.(....).)))).......))))))).....))))).))))))))))........(((....)))....)))))))).....))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((....((.(((((((.....(((....(((..(.((((...((.(((.....))).)).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........((((..(.....)...))))....))....))...(((((........)))))]]((((..(((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((....)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.....((.....((((....)))).....))..))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..((((((((((....(((...........(..(..(......)............)..)..))).....))))))))))....((((.....((((..((((()))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(((.((..)..).)))..)))))...)))....)))).)))))).))))).. FAP-80S Complex - Rotated state; 25S ribosomal RNA (RDN25-1) 7zw0 2 1765 2.4 RF01960,RF02542,RF01959,RF00177 URS00005F2C2D_580240 36113412 0003735 0005840 580240 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggccggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugagcuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauu ...<<<<<.{.[[[[>>>>><<<<.<<<<<<...<.<...<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<..<<..<<....<<<..................<<....<<.<<<.....>>>.>>.....>>.........<<<<<..<<....>>..>>>>><...<<<<<<......(((((((.<<<....>>>....<........>>>>>>>.....>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>..>>>..>....>.>.....<<<<<<<<<.<..>.>>>>>>.>>>......<<..<...........>..>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>>>>>.........<<<[[.....<.<<...<<<.<<....<<<<<<.<<<<..............>>>>.>>>>>>....<<<<<<....................>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........<<<..<<<<<<<<.....))))))).>>>>>>>>.>>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..]]>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..]]]].}<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<.<<<<.<<<<....>>>>.>>>>.>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>........ ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[[[[[[.(((....))).....(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(((((((((.(()).)))))).)))....(.(((.(...........)).))......)..((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((................))).))))))....((((((....................))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(....(.((.((......]]]]]]]..)).)).)...).....))...(((..((..(...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)..))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].].((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((.(..(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..))))).)..))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....((((((((.......))))))))......))...)))))))))).)...(.(..((.(..((((.((..(.((((((((.(((..(.((..(...(((((((.((((.((.(....).)).)))).)))))))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>....... FAP-80S Complex - Rotated state; 18S ribosomal RNA (RDN18-1) 7zw0 sm 29 2.4 36113412 580240 aaaaaaaaaaagcugcuaaaaaaaaaaaa ............................. ............................. FAP-80S Complex - Rotated state; mRNA 7zw0 sl 76 2.4 RF00005 URS0000EEAD03_580240 36113412 0030533 0006412 580240 gggcguguggcguagucgguagcgcgcucccuuagcaugggagaggucuccgguucgauuccggacucguccgcca <<<<<.<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>.>>>>>.... ((.((.(..((((....[...)))).(((((.......))))).....(((((..]....)))))).)).)).... FAP-80S Complex - Rotated state; tRNA 7zw0 sn 76 2.4 RF00005 URS0000EEAD03_580240 36113412 0030533 0006412 580240 gggcguguggcguagucgguagcgcgcucccuuagcaugggagaggucuccgguucgauuccggacucguccgcca <<<<<.<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>.>>>>>.... ((.((.(..((((....[...)))).(((((.......))))).....(((((..]....)))))).)).)).... FAP-80S Complex - Rotated state; tRNA 7zw0 LC 121 2.4 RF00001 URS000055688D_580240 36113412 0003735 0005840 580240 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). FAP-80S Complex - Rotated state; 5S ribosomal RNA (RDN5-1) 7zw0 LD 158 2.4 RF00002 URS00001BF64E_580240 36113412 0003735 0005840 580240 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... FAP-80S Complex - Rotated state; 5.8S ribosomal RNA (RDN58-1) 8a22 A1 109 2.91 URS000261776F_353565 36253367 353565 ugugaccguuagcgcauaguacaguaauggaagugcauaaaccaaauuaaaggcuuaaauuaaaaauaaaauggcuggugcaauggcacaaaaaauaagaaaguuuaaa <<<<.<<..............<<....>>....<<<<....<<<...........................>>>....>>>>..>>>>>>................... ((((.((..............((....))....((((....(((...........................)))....))))..))))))................... Structure of the mitochondrial ribosome from Polytomella magna; mtLSU-1 8a22 A2 81 2.91 URS000261777F_353565 36253367 353565 aauaaauaaguuuaauaccuuuugcagcauggaccagcgauuaaaugccgguaauuagcaaaguuaaacuaacgaaaaaua ..<<<<<..>>>>>...<.<........>.>........................<<<<...>>>>............... ..((((....))))...(.(........).)........................((((...))))............... Structure of the mitochondrial ribosome from Polytomella magna; mtLSU-2 8a22 A3 207 2.91 RF02541 URS0002617776_353565 36253367 0003735 0005840 353565 uuacaggcauuuaauucgaagcauagcgagcuaacguuuagcagguuugcauaaauuaaauauauuaaaaaagcaagaccgcaaagguuucuguagcaauagaaucuugugacuuaacguuaggggcgauaaaccaaucacgcuauggcauagcuaaguuucugcgaaauauauuuagguauagcuuaaaaaacuuuauagauaaaa ..............<<.<..<<<<<<<.....<<<<<<.<<..<<<<<<<.....<<<<.....>>>>....>>>>.>>>...<<<..<<<<........>>>>.>>>....>>.>>>>>>...<<.......>>......>>>>>>...>..>.>>............<<<<<....>>>>>........................ ..............((.(...((((((.....((((((.(((.(((((((.....((((.....))))....)))).)))...(((..((((........)))).)))..).)).)))))).(.((.......))...)..))))))......).))............(((((....)))))........................ Structure of the mitochondrial ribosome from Polytomella magna; mtLSU-3 8a22 A4 73 2.91 URS000261775F_353565 36253367 353565 uaagucagacgcaaagcuacaagguuucgcgucaaaaggaaaaaaguccgccagcgaggcuaagguacauaaa .......<<<<<.<<<<......>>>>.>>>>>....<<<......>>>........................ .......(((((.((((......)))).)))))....(((......)))........................ Structure of the mitochondrial ribosome from Polytomella magna; mtLSU-4 8a22 A5 136 2.91 RF02541,RF02540 URS0002617788_353565 36253367 0003735 0005840 353565 uaaugugcaccaaacaaccaggaggugggcuuggaagcagccauccuuugaagaaagcguaauagcucugcuuuuuguguaacauuacacuacacgcagaaaauaaaagccgaagcucgcuuguucaguuaaauau <<<<<<<<<<.....<<.....<<...<<<<.......>>>>...>>........<<<......>>>......>>.>>>>.>>>>>>................................................. .(((((((((.....((.....(((..(((.........)))..))).....(...((......)).).....)).)))).))))).................................................. Structure of the mitochondrial ribosome from Polytomella magna; mtLSU-5 8a22 A6 109 2.91 URS0002617775_353565 36253367 353565 gcagguagcagaacguucuauauaauagaauugcuaaugcugguauaaguaacuauguaaaaauacagcuaagcuaaagguuuugcgcaacagugaaacgauaaaguaa .............<.<<<<<<...>>>>>>..>.......................<<......>>.................<<.....>>................. .............(.((((((...))))))..).......................(((....))).................((.....))................. Structure of the mitochondrial ribosome from Polytomella magna; mtLSU-6 8a22 A7 534 2.91 RF02541 URS0002617768_353565 36253367 0003735 0005840 353565 aaucguaccgcaaaccaacacagguuaguuauuguaaaggcuguauaaaaccaggauaaaggaacucggcaaaauagguuauguuuucguacaaaaccacaacaaaaguagugacuguuuaccaaaaacacaagacucugcuaacacuuauaguggaaguauagugucugauaccugcccaaaggcaaagcaaacggcagcuguaacucuaacggcucuaagguagcaaaauuccauggcauuuaaaugaugucccgcaugaaugguauaacaacuucuuaacugucucuauucuggauuaggcgaacuuuaaaugcuugugcagaugcaggcuagcuaacaagggacgaagagacccuaugcagcuuuagggcagguuauuauucaauaaacuaccuuuuuucugggacggacgcucuuauuaaagaaacaagagugagcaaugguuuuuacuaauuauaaaaaagaaaagcuuaacugcaauacaaacaauuaaagcaggggcauugucggcaauaaugcauugaagaaaua ..............<<......>>...................<<.....<<<<<<<<.<<.........<.....<<<<.<<<......>>>.>>>>.......<<<.<<<<..<<<.........>>>..<<<<.<<.....<<<.....>>>.......>>.>>>>.<<<<<.<<<.....<<...>>....>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>.>>>...>..>>.>>>>>>>>..>>..............<<<<<........>>>>>....................................<<<<..<<<<<<<....>>>>.>>>.>>>>...<<<.....>>>.<<<<<<...........>>>>>>..<<...<<<<<<..<.....((......>.>>>>>>...<<<<..<<........>>..>>>>.<<<...>>>.>>.))................. ..............((......)).........[.........((.(...((((((((.((..(....(.......(((..(((..{...)))..))).].....(((.((((...((.........))...((((.((.....(((.....))).......)).)))).}((((.(((.....((...))....)))(((((.........)))))........((..........((((((.....))))))..)..)....))))...)).)).)))..)..))).)))))))).)))...........[..(((((......].)))))....................................((((..(((((((....)))).))).))))...((......[))..(((((..........])))))...((...(((((((.((....[[.....)))))))))...((((..((........))..)))).(((...))).)).]]................. Structure of the mitochondrial ribosome from Polytomella magna; mtLSU-7 8a22 A8 350 2.91 RF02541 URS0002617774_353565 36253367 0003735 0005840 353565 cguucuucaaccaacggaauaaagcuacgcuagggauaacaggcuuauucgcucacagaguuuuaucgacgagcgcgguuggcaccucgauguuggaucaccgcuuccuguagcugcaaacgguuauaaggguuagacuguucgucugauaaugcgguacgugaucugaguucaaagcgucguaagacaguuugguuucuaucuuuguuagcauaaguauuacggcguuguguacaguacgaaaggauuguugcacaauuaaccaauaguuuaaagagcaacguuaauaaaccggaaaacuuuuaacugcacugugcaguugcaggcaaagcaauguucagcuaaaaaaa .........................................<<<<.<..<<<<<...<<......>>...>>>>>....>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>.....................<<<<.<<.<<<...<<<<<<.................>>>>>>.<<<<<.....<<.......>>...>>>>>....>>>..>>>>>>...................<<..<<<......>>>...>>........ ........................................(((((.(..(((((...((......))...)))))....)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).)))).....................((((..(.(((...(((((((....(....)....).)))))).(((((...(.((.......)).).)))))....))).)..))))...................((.((((......))).).))........ Structure of the mitochondrial ribosome from Polytomella magna; mtLSU-8 8a22 B1 102 2.91 URS0002617782_353565 36253367 353565 cauaggguuugguuuuugcccagccuuuagcuuagcguuaagcuuauacaugcuagccuaaaagacggcgcacaggugcauauuuuguaagcauguaaaaua ....<<<<.........>>>>..................................<<<........>>>................................. ....((((.........))))..................................(((........)))................................. Structure of the mitochondrial ribosome from Polytomella magna; mtSSU-1 8a22 B2 210 2.91 RF00177 URS0002617766_353565 36253367 0003735 0005840 353565 aaaguguacuuuauaaagucauuguauugcuuacaaauaacuaggcaguugggucggcugcuauacuauagcgccccaagccugauaauuagcuaggcguaacagcggcaagccacaguagcacauaaaaauugcuaccguuaacgcagcaguaagaaagauuggacaauagcuuaagggcagauccagguaagcgcuaaaaucuuugug ..<<<<.<<<<....>>>>>>>>.............<<.....<<<..<<<<<.<<...............>>.>>>>>>>>.....>>..<<<..<<......>>....>>>....<<<<<<.........>>>>>><<<..>>>.................<<<...<.<<<....>>>..>>>>....................... ..((((.(((......))))))).............((.....(((..(((((.((...............)).)))))))).....))..(((..((......))....)))....((((((.........))))))(((..)))...............(.(((...(.(((....)))..)))))...................... Structure of the mitochondrial ribosome from Polytomella magna; mtSSU-2 8a22 B3 373 2.91 RF00177,RF01959,RF02542,RF01960 URS0002617754_353565 36253367 0003735 0005840 353565 gagcuccggcuaauugugugccagcagccgcgggaauacacaaggggccaguuuaagguuaaaacaaggcaacgguguuuaaaaacuggaaaugcgccuaaaauagcuuaaugcguuggaguaaggguuaaaucuguaaaaaccuugcagaaagccuuaaaguaaaagcagcuauucaugcccauaaaacagucuauaaacgagagcugcgguagcaaaacggauuagauacccguguagucccagccguaaauuauuuauuaaauuaaagcgccuagcgauauugccuauggcacuaaacuagggaaucugacagcauuaagcgguggagcauacuucuuaauuugauaauacgcaaaaacauuaccacgau ..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>...................<<<......<<<<<...<<.....<<<.<<.<..<<<<<<<<..<<<...<<....<<<......>>>.......>>..>>>..>>.................>>>>>>.>.>>.>>>......>>...>>>>>....<<<<.<...<<...<<<<.<.....>.>>>>...>>>.>>>>.........<<<<......>>>>..>>>.<<......<<<<...>>>>.....>>...........................................<<........>>................ (.((((([[[...(((((.....((.]]])).......)))))))))))..................(((....(.((((....((.....(((.((.(..((((((((..(((...((....((........)).......))..)))..)).................)))))).).)).)))......))....))))....((((.(...((...((((.........))))...))).)))).........((((......)))).)))).((......((((...)))).....))...........................................((........))................ Structure of the mitochondrial ribosome from Polytomella magna; mtSSU-3 8a22 B4 332 2.91 RF00177,RF01960,RF02542,RF01959 URS000261777D_353565 36253367 0003735 0005840 353565 aaaccacgguauugcauggcugauauauaauccauacaaaggauauaaccaaguagcauggucuuauauugugggcuggcggugugcuacaaguaacaaaaaguacaaccggauuaauuacugaaaucauaaauauaaagagggaaucgcuaguaaucuuuauuauaacauaaaggugaacuagugugcacacacugcccgucacauccgggaaaaccacaaagcccuaaguuuguauaguguuuaauaaaccaauucaaacauaagcuuauuguuaacaaggaugaagucguaacaagguuugcguaggggaaccugcucaagauuaugcu .......<<.<<...<<<<<<.....<<<.<<<.......>>>>>>.....>>>..>>>.>>>>...............................<<.....>>.....<....<<.<<<.........>>>.>>....>...............<<<<<<<<......>>>>>>>>...................<..<<.<.<<<<<..<..<<<.<..<<<<....<<<<<<.<<.<.<<.......>>>.>>.>>>>>.>..>>>>.>.>>>..>..>>>>>..>.>>...>.....<<<.<<<<<....>>>>>.>>>......... .......((.(((...((((((....(((.(((.......))))))...).)))..)).))))).........................(.....((.....)).....(....((.(((.........))).))....)..)............(((((((((...).)))))))).................(.(..((.(.(((((..(...((.....(((.....(((((.((.(.((.......))).)).)))))....)))....))...)..)))))..).))...)..)..(((.(((((....))))).)))......... Structure of the mitochondrial ribosome from Polytomella magna; mtSSU-4 8a3d A 3303 1.67 RF02543 URS00026813B2_9606 36909531 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagngngaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgggcggaucugaccgucggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucggccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggaggucgccgcgcucuccccccugggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccggggggccacgcgcgcgucccgggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccnucuugnaacncggaccaaggagunuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggccgaggugggaucccgaggccucucgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccnanagauggugancuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauagnggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucggcaguuuuauccgguaaagcgaaugauuagagguaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcngaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacaggaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcaguccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaunuuggugguagunnnaaauauucaaacgagaacuuugaaggccgaaguggngaaggguuccaugngaacagnanuugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggggccgaucgaaagggagucggguucagauccccgaauccggagcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccnuauccgcagcaggucuncaaggugaacngccucuggnauguuggaacaanguagguaagggaagucggcaagcnggauccguaacuucnggauaaggauuggcucuaagggcuagccgacuuagaacuggugcggaccaggngaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugccnagugcucugaaugucanagugangaaauucaaugaagcgcggnuaaacggcgggagcucucuuaagguagcnaanugccucnucaucuaauuagugangcgcaugaanggaugancgagnuucccacugunccuaccuacuauccagcgaaaccacngncaagggaacgggcuuggnggaaucagcggngaaagaagacccuguugagcuugacncuagucuggcacggugaagaguuuuucacugacccggugaggcggggggcgcuucuggcgccaagcgcccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacugnggcgguacaccugucaaacgguancgcaggnnuccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucagnacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggangugucagaaaaguuaccacagngauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuungaugucggnucuuccuaucauugugaagcagaauucaccaagcguungaunnuucacccacuaauagggaacgugngcugggnuuagancgucgugagacagguuaguuuuacccuacugaugnuguguuguugccaugguanuccugcucaguacgagaggaaccgcagnuncanacauuugguguaunugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccgguccccgggguccggugcggagugcccuucguccugggaaacggggcgcggccggaaaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuugggucgggguuucguacguagcagagcagcgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>>..<<<<<<<<..<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>.....>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<......>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<<<..<<<<<...<<<<.<...>>>>>..>>...>>>>>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<<<<<<<<<<<<<<<<<...<<..<<<....<<<<......<<<<<..>>>>>.......>>>>...>>>........>>>>>>..>>>>>>>>>>>............<<<<<..<<<<<<..>>>>>>.<<<<<<..<<<.<<<<<<<<<<.<<<<<<<<<<<<<.<<<<....>>>>.>>>>>>>>>>>>.>.>>>>>>>.>>>...>>>.>>>>.>>..<<<<<<<..>>>>>.>>.....>>>>>.....>>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<<<<...<<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<..>>>..<<<<<...<<<..<<<.....>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>>.<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<...<<<.<<<<<<<<<...<<<....<<<..<.<<<..>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.........>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<..........>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<................>>>>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>.................>>....>>>..<<<<<........>>>>>))<<<<.<<<<<..<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<...............>>>>><<.<<<<<<<<<..>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<..>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<..>>>>>>>...<<<<<.....<<<<..................<<<<<<<..>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>><<<<....>>>>>>)))].....<<<<<<<..<<<..)))))).>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<...<<<.<<<<<<<]]].>>>>>..>>.>>>..>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.....<<<<<<..<<..<<<<....<<<........<<<<<.<<<..>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>..............>>>>..>>.>>>>>><<<<<..................<<.<<<<<<<.<<.....<<<<....<<<<..>>>>...>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..((((((((((.......))))).))))....))))....(((((((....(((((((..({((((......)))))....[[(...).(((....}]])))...).)))))).......)))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....(((((((((.(..(((((....(((.((.)))))...))...)))).)))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((..(.((((......(((((..))))).......)))).).)))........))))))..)))))))))))............((((((.((((((..)))))).(((((...(((.((((((((((..((((((((((((.((((....)))).))))))))))))...))))))).)))...)))..))).))..(((((((..))))).))....)))))).....))).)))))...)))))...)))))))).[((((........))))((((((..(.(((((((((((((..(((..(((((........))))..)..)))...((....))...(((.).))..(((((...(((..(((.....)))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((.(((((((...(((.((((((((.....((.....((....(((..)))....))...))......))))))...(((((((((.(......))))))))))....))))))))))))..))..((((..(.((.....)).)..))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((..........)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((................)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((..(((((((...((.....)).))))))....[[(((.((...(.....(((....)))...(.)............)....))...(((((........)))))]]((((.(((((...(((((((....)))))))..((((....)))...(...((((((...((((((((((((((((((((((...{{{...)))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).))).))).....((......)).)))).((((.....))))..)))....(((......(.((((..((..(....(.......(((((....(.{..).....)))))((.(((((((((..)))..)))))).))(...).......(((((((((.].(...........)...(((((((....((((.....))))......))))))).}.(.(.(((..((((((.....(......(((......)))......)..))))..)))))(((....)))........((..........(((((.......)))))..)..)....).)....)).))))))).)..)))..)))).)...)))))....)).{..((.((.....]}.)).))....(((((..(((.((......((((.(((((...(((((.(((((((((.(((((((..)))))))...(((((.....((((..................(((((((..)))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(..((....((....{..))....)).)(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}.....)))..)))))).......(....(.((((.(...((.......))...).))))...)....)........((((.((((((..(.(.(.(((......))).)...).)..((.(.....).))......)))))..)...))).)......((((((....))).)))...>.))..))).))))).....(.((.(.(..(((..(.(((((......(....).....))))).)(((.....((((....((.(((((((}}}.)))))..)).))...))))....))).((((...((((.............))))...))))..)))...).).)).).....((((((..((..((((.(..(((........(((((.(((..))).))))).......)))...(((...(((....((((.(((((((......)))))))))))...)))...)))...........)..))))..)).))))))(((((....(.......).....((.(((((((.((.....(.((.(..(((....)))..))).)....))....)))).))).))..))))).. Human mature large subunit of the ribosome with eIF6 and homoharringtonine bound; 28S ribosomal RNA 8a3d B 120 1.67 RF00001 URS00000F9D45_9606 36909531 0003735 0005840 9606 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. Human mature large subunit of the ribosome with eIF6 and homoharringtonine bound; 5S ribosomal RNA 8a3d C 148 1.67 RF00002 URS0000005270_9606 36909531 0003735 0005840 9606 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauuncaggacaugaucaucgacacuucgaacgcacuugcggccccgggcccggggcuacgccugucugagcgucgcu .........................................<<<<<<<<<....>>>>.....<.<<<......>>..........>>>..>...>>>....<<....>><<<<<<<<..>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]]..........)))..)...)))....((....))((((((((..)))))))).................... Human mature large subunit of the ribosome with eIF6 and homoharringtonine bound; 5.8S ribosomal RNA 8a3l A 1539 3.42 RF00177,RF01959,RF02542,RF01960 URS00023358EE_83333 36840711 0003735 0005840 83333 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacagaacuuuccagagauggauuggugccuucgggaacugugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuaucuuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<.<<<<..........>>>>..>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<..<<<<....>>>>..>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((.(((............)))..))))..)))))......(((......(((((((..((...((((.((.(.((.....((((.(....).))))......)).).....(((....)))....(((.((..((....)))).))).)).))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....(.(((.((.......)).))).).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(..((((....))))..)....(....)...))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.((.((((...((..(.(......))))....)))).))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Structural insights into the binding of bS1 to the ribosome; 16S ribosomal RNA 8a3l V 77 3.42 RF00005 URS00001BBAFC_83333 36840711 0030533 0006412 83333 cgcggggnggagcagccuggnagcucgucgggcucauaacccgaagaucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Structural insights into the binding of bS1 to the ribosome; P-site fMet-tRNA(fMet) 8a3l W 77 3.42 RF00005 URS000041AF00_83333 36840711 0030533 0006412 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Structural insights into the binding of bS1 to the ribosome; E-site tRNA 8a3l a 2903 3.42 RF02541 URS00026813FB_83333 36840711 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggaggagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcaugcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaacucaucuccggggguagagcacuguuucggcaagggggucaacccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugugaagguguacugugagguaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaagcgacuugcucguggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacuccuugagaguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<.<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>.>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<.........>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<....<....<<.........>>....>..........<........>.....>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<..........>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<......>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<..<<....>>...>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<......................................<<<....>>>....................................>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. (.((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((........((.((((((((.(((...(((((......)))))[[......(((.....]])))...)))...)))))))).)).....))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((.((....)).)))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))..(((((((..((((((((((.....(((...(((.((((...((................))...)))).)))..)).).....)))))).)))..)))))))).....(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{..((..((.........................).......(.........)..).))....)))..))))).))...........]]].)...))))))))))...)))))))((((((..........))))))....))))))(.(((((....((......((((((((....))))))))...))...)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..((((......))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((((..(..........................(.............(......)...........)..........................)..))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....((((((..((..]]]]..)).)))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))).). Structural insights into the binding of bS1 to the ribosome; 23S ribosomal RNA 8a3l b 120 3.42 RF00001 URS0000049E57_83333 36840711 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Structural insights into the binding of bS1 to the ribosome; 5S ribosomal RNA 8a3w S1 1663 2.89 RF01960,RF02542,RF01959,RF00177 URS0002915692_347515 0003735 0005840 347515 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CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME : WILD TYPE; SSU_rRNA_chain_S1 8a3w S4 17 2.89 URS00029156C6_347515 347515 gcgcgguccgcgcacca <<<<<<.>>>>>>.... ((((((.)))))).... CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME : WILD TYPE; E-site_tRNA_chain_S4 8a3w 8 119 2.89 RF00001 URS00000FEF50_347515 0003735 0005840 347515 gaguacgaccacacuugagugaaaacaccauaucccguccgauuugugaaguuaagcacucacaggcucaguuaguacugaggucagugaugacucgggaacccugagugccguacucc <<<<<<<......<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<......<<<<<..<<....>>.>>>>>.....>>>>>>..>>>>>>>. (((((((.(....((((((((.....((((((...(....)...))))..))....)))))).))((((((......(((((..((....)).))))).....))))))).))))))). CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME : WILD TYPE; 5S_rRNA_chain_8 8a3w 6 63 2.89 URS00005EBAC0_347515 347515 ucgaaucgccaccuacaagacuggagcuugcucggcgccaaguauauucaugaucacaagaca .......<<<.............<<<<..>>>>>>>........................... .......(((.............((((..)))))))........................... CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME : WILD TYPE; SR6_chain_6 8a3w 2 947 2.89 RF02543 URS00029156E4_347515 0003735 0005840 347515 ccaacugcagaccguacucaucaccgcaucagguccccaagcauagaaugcucugguacauagagaaangnacacucagggaagucggcaaanuagaugcguaaguucgcaagaagcauuggcucugagggcaaaauugccaacucagaacugnuuacggcggggaauccaacugunuaauuaaaacauagguuugugaugcauccaagugguguauaucgcaaacugauuucugccnagugcucugucaacgugacgagauucaccgacgcgcggguaaacggcgggcucucuuaagguagccaanugccucnucuuccaauuagagacgcgcaugaanggauuaaugngnuucccucugunccgaguuncuaucuagcgaancgacagucaagggaacggacuugnagggcuaagcggngaaagaagacccunuugaguuugacnccagucuggcucugugcgguucacuuaucgaaugaagagaccaauggguuuagcguagucuggcuaugcaccgucuagguuccgugcuguaaacugaaccaacgggaguuccggagucuuguuucgagacaucugccagauggggaguuuggcugnggcggcauaucuguuacacgacaacgcaggnnuccuaaggcgagcucagugggaucucacguagaacacaagcguaaaagcuugcuugauuaacgauunccaguangaaucgagacugcgaaagcaaggccngcgauccuuugcgaugaacaaaucauaccanangugucagaauaauuacnacagngauaaggcuugauccuungaugucggnucuuccuaaccuagcggcuaaggguuggaunnuucacccacugncagggaacgugngcuggguuuagancgucgugagacagguugguuunacccuacuuagcuggaaauugcgagaaaaauccguaagc .......................<<......>>......<<<<<...>>>>>........<<<<....<<<<.<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<..>>>>>..>>>>>>.>>..........<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<<....<<<<......>>>>....>>..>>>>..>>>>><<....>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>>.>>>>............<<<<<........>>>>>..<<<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<...<<<.<.>.>>>...<<<<<.....<<<<...........<.<<<.........>>>.>...............................<<<<...>>>>..>>>>...>>>>>.......>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<..>>>>>.....<<......>>....>>>>>>>...<<...<<<<<.......>>>>>..>>.<<<....>>>.>>.........<<<<<..<<<.......>>>..>>>>>..........>>>>..>>>>>>.....<<.<.>.>.>.......<<<<<.<<<<<<..<<<<<<.>>>..>>>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>>>.......................... .......................((......))......((((.....))))........(.((.....(((.((.(.((..(....(.......(((((....(.[..).....)))))((.((((((((.((..)).))..)))))).))..........(((((((((...((.........))...(((((((....((((.....))))......))))))).].(.(.(((..((((((.((....(((........)))....))..))))..)))))(.(..).)........((..........(((((.......)))))..)..)....).)....)).))))))).)..))).).)))))..)).).........[..((.((......].)).))..(((((((..(((.((......((((.(((((...(((((.(((((((...(((.(.).)))...(((((.....((((...........(.(.(.........).).)......(......).................(((.(.).)))..))))...))))).......)))))))..)))))..(((......[)).)(((.(...........].).)))([((...(((((((.(.(((((())))))...).((][..[.))....))))))).(.(....(((((....{..)))))...))(((....))).)).].].....((.((..(((.......)))..)).))....)}.....)))..)))))).....(........)........((((.((((((..((((((.)))..)))..((.(.....).))......)))))..)...))).)......((((((....))).))).....))..))).))))))).......................... CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME : WILD TYPE; LSUb_rRNA_chain_2 8a3w 7 163 2.89 RF00002 URS0000A76380_347515 0003735 0005840 347515 aacgugncgcgauggaugacuuggcuuccuauuucguugaagnacgcaguaaagugcgauaagugguaucaauuncagacauucaauuaccgaaucuuugaacgcaaacggcgcaugggagaagcucgugucauccccgugcaugccauauucucngugucga .........................................<<<<<<.((.....>>>.....<<<<<......))...........>>>>.>...>>>....<<.....>><<<<<<<.<..<<....>>..>.>>>>>>>..................... .........................................((((((.[[.....))).....(((((......]]...........)))).)...)))....((.....))(((((((....((.().))....)))))))..................... CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME : WILD TYPE; 5.8S_rRNA_chain_7 8a3w 5 98 2.89 URS00027E5B07_347515 347515 uacgucccucuccaaacgagagaacaugcaugggcuggcaugagcgguggggcucgucccgaggcgcugaaccuugaggccugcaugcucagggacac ...<<<<<<<<<.......>>>>....<<<<<<<<.<<.....<<<.<..<<......>>..>.>>>....>>.....>>>..>>>>>...>>>>>.. ...(((((((((.......))))....((((((((.((.....(((....((..()..))....)))....)).....)))..)))))...))))).. CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME : WILD TYPE; SR4_chain_5 8a3w 4 158 2.89 RF02543 URS00029156A6_347515 0003735 0005840 347515 gggaucucgcagguaucgugagggaaguaugggguauacgggaacucccaugccgunccucuaguuucugggguuugucgaacggcaagugccccgaagccaucgcacggugguucucggcugaaagccagaagccaaucccaagaccagaugcccac <<<..>>>...<<<<<<....<<<<.<<<<<<<<...........>>>>>>>><<<<<...<.<<....<<<<<<<<<......>>>>..>>>>>...>>.>..>>>>>.<<<<....<<<<...>>>>....>>>>.>>>>.......>>>>>>... 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CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME : WILD TYPE; SR1_chain_3 8a3w 1 1467 2.89 RF02543 URS00029156BD_347515 0003735 0005840 347515 agaccugaguguggcaggacuacccgccgaacuuaagcauauuacucagcggaggaaaagaaaacaaccgugauucucucagugagcggcgagcgaagagggaacgaacucguugccgaaucgggucuuacaaggccuugaguuguggcacgugguuggugcaggaguggcgaaauucaagaaagcaaacccguugcugaauacaaucauggnguauugagccaaagaagguguuagcccauugagccauaaaccugagcgccucaugaacuaagcgnguagcacuguuugggaaugcagugucaaguuggcagguauuugucugccaaaguuaaauacagaguaggaagaccgauagcgaacaaguagcgugagcgaanguuugaaaagcacuuuggaaagagagugaaauagaaccugaagucgugacaaagacaauggaaguaccuccauuucaacggccagaaccagcccuugcauuauccugugggaaauccggcggggugcaaugguguuggcgauggaaauggggugcccccacccgucuuganacncggaccaaggagunanacagacgcgcaagggaggagauaugccaguacuucucucguacugaaagggagaugcaaugcaucuguggugugcacacgucaaauccguuugauuugcccaacaccgaccggcccuccguggguugcguuggagugugccngnuuggacccnanagguggugaacuaugccugaacaaggugaagcccggggaaacccagguggaggccuguagcgaugcugncgugcaaaucgcucguaugauuugggunucgnagcgaaagacucaucgaaccaccuaguagcugguucacaucgaaguuuccnucaggauagcuggugcuaguagaaguauugugcgguaaagcacuuuaaangugcaaacaaaccggccuuagccaacugcaaggccggaaagaaaagaauuagaggcaccaagugggccuucuucgguaagcngagcaggcgaugcggaaugaaccgcuuagggauauguggcgucaaaacuuaugggcucauucucgauacgugaaaaggguguuggugcaccggccccgaaaauggangacgcuuaagcccaauuagugauugcccauuauuccuuugguaagggcgagaaaguguagcccuuccgauguagauguggccuggagguuaggacgaagcuuauggcgugagccuaagauggaccggccucuagugcanaunuugguuggcgunncaaagaucuaacggagauauacucaacaugcaacguuggauacuggagcggggaaggauuucgugccaacggcacucguacacganuuguucggaaacugagcacaacguuauaucgunuuguuaggaaagugaaggaacugaaaaggggcaacagagaaccugggauuauauuccaaaaagaaauugcauguggg ......................<<<<<......<......>.......>>>>.>.........<<....>>..<<<<<<......<<.....>>....>>>>>>...<<<...<<<<<..<<<<<<<......>>>>>.>>....>>>>>.<<<...<<<<<<<<.<<<<<......<<<...<<<<.......>>>>.....<<....>>.....>>>.<<.......((.....>>)).....>>>>>...>>>..>>>>>.>>>..............<<<<<<<........>>>>>>>......<<<<<........>>>>>..>>>....................................<<....>>................<<<<....>>>>..................................<<<..<<<<<<.<<<<<......<<<<.<<<<.....<<<<<...<<<<<<<....>>..>>>>>>>>>>.>>>>.>>>>......>>>>>>>>>>>..>>>.<<<<........>>>><<<<<<....<<<<<<<.<<<<<..<<<<..<<.<........>>>..>>>>...<<....>>..<<<<<...>>>>>...<<<<<...<<.<<<<<<....>>>>>>.>>....>>>>><<<<<<<<<.....>>>>>>.>>>...>>>>>.>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<.<<<....>>>.>>>.....>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>...<<<<<....<.<<<....>>>.><<<<<<<<<.....<<...<<<<<<....<<<..>>.>....>>>>>>.....<<<<<<<<.<<.....>>>>>>>>>>...........>>...>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>...<<<<......>>>>..<<<<<<<...<<<(((......<..<<<<........<...........<<<<....<..>....>>>>...........))).>....>>>>.>.........>>>...>>>>>>><<<<.<<<<<.............>>>>>>>>>....>>>>>..<.<<<<<<<<........<<<<..<<<....>>>.>>>.>.....>>>>>>>>..>.....>>>>>>..............<<<<<<<....................>>>>>>>....................<<<<<....<<.....>>..>>>>>....<<..........<<.<<<<<......>>>>................<....>......>.>>..........<<<<.........>>....>>.>>........... ......................(((((......(...[..).......)))).).........((....))...((((.......((.]...)).....))))....((((..((((..((((((((......))))).))....))))).(((...((((((((.(((((....({((....((((.......)))).....((....))......)))[[(...)..((....}]])).....)))))...)))..))))).))).........)....(((((((........)))))))......(((((........)))))..)))....................................((....)).............(..((.(....).))............)......................((..((((((.((((((.....((((.((((.....(((.....((((((......)..)))))..))).)))).))))....).)))))))))))..))..(((..........)))((((.(....(((((.(.(((((..(((...((.((......))))...)))...((....))..(((((...)))))...(((((...((.(((((......))))).))....)))))(((((((((.....)))))).)))...))))).).)))))..((.(...((((((.....((((((((((.((((...(((.(((....))).)))...).)))...(((..((.((........)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).).((((((((.....((.(.((((((.....((..))......)))))).....(((.((((.((.....)))))).)))..........)))...))))))).)...((((.((.((.....)).)).))))....(((......)))...((((((....((([[[...(..(..((((....................((((....(..)....))))...........]]]......)))).))........)))....))))))((((.((((((......).....)))))))))....))))).)(.((((((((.(......((((..(((....))).))).)...).))))))))..).....).))))..............(((((((....................)))))))....................(((((....((.....))..)))))....((......(...((.(.(((......))).............................).))....).....((((.........))....)).))........... CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME : WILD TYPE; LSUa_rRNA_chain_1 8a57 A 2908 2.3 RF02541 URS000261774E_169963 36300626 0003735 0005840 169963 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((((((......((((((((((.....(((..(((((((((((((......((((((.[[..[[[)))...].((((((...(((]]..]].)))......))))))...)))....(((....)))(((((((......))))))).(((((((((.........))))))))).))....((((((.....(...[..)......))))).).........((....))...((((......((.]...)).....))))...((((...(((((((((..)))))))))....{.(((((((((.....((((........((((((.((.(((...(.((((......)))))[[(...).(((.....]])))...)))...)).)))))).)))).)))))..)))))....((((((((..[......))))))))....}.(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((..((((..[...))))..)))).<.(.(........).).((((((....(((((((((((((..(((...((.......))...)))...((....))..((((.....))))......)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)<)))...(((.(((((.......A))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))((((((((....((((((((((.....(((...((((((((...((((((.......)))).))...))))))))..)).).....))))).)))).).)))))).))..(((((((.((......)).)))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{..((...(((..(((.........)))..))).....(...((......)).)...))....)))))))))).))...........]]].)...))))))))))...)))))))((((((()))))))....))))))(.(((((((.((......(((((.((....))])))))...)).)))))))..).....))))))(......((....((((((.......))))))((((....(((...((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]]((((((((.((......((...(((((...((((..(((..(((((.(((((....{{....))))).((..(((((..((((.((((((.((.....))))))))......))))..)))))...))..........)))))...)))...))))(..)....)))))..))..)).)))))))))))).))).....((......))..))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))(((((....((((....))))...)))))(...).......(((((((((.>.((.........))...(((((((.....(((....)))..[....))))))).}((((.(((..(((((((..(((...((...(((((..((....))...)))))...))...))))))))..)))))((((((.......))))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).[..(((((.....>].)))))..((((((((.(((.((......((((.((((((..(((((.(((((((((.(((((..((.....(..(..........(.....(.................................)................))..).....))..)))))....((.((((((...].)))))))).....)))))))))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..a.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((....))))....(((.(((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))....)))...))))))).. Cryo-EM structure of HflXr bound to the Listeria monocytogenes 50S ribosomal subunit.; 23S ribosomal RNA 8a57 B 114 2.3 RF00001 URS000261774D_169963 36300626 0003735 0005840 169963 cugguaguuauggcgagaaggucacacccguucccauaccgaacacgguaguuaagcuucucugcgccaaugguaguugggggcuucccccugcgagaguaggucgcugccggg <<<<<<<<....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>><<<.......<<.<<<<<...>>>>>.>>.......>>>.>>>>>>>>. ((((((((....((((((((.....((((((...(.....)...))))..))....)))))).))(((.......((.(((((...))))).)).......))).)))))))). Cryo-EM structure of HflXr bound to the Listeria monocytogenes 50S ribosomal subunit.; 5S ribosomal RNA 8a5i A 2908 2.3 RF02541 URS000261774E_169963 36300626 0003735 0005840 169963 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((((((......((((((((((.....(((..(((((((((((((......((((((.[[..[[[)))...].((((((...(((]]..]].)))......))))))...)))....(((....)))(((((((......))))))).(((((((((.........))))))))).))....((((((.....(...[..)......))))).).........((....))...((((......((.]...)).....))))...((((...((((((((....))))))))....{.(((((((((.....((((........((((((.((.(((...(.((((......)))))[[(...).(((.....]])))...)))...)).)))))).)))).)))))..)))))....((((((((..[......))))))))....}.(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((..((((..[...))))..)))).<.(.(........).).((((((....(((((((((((((..(((...((.......))...)))...((....))..((((.....))))......)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)<)))...(((.(((((.......A))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))((((((((....((((((((((.....(((...((((((((...(((((((.....))))).))...))))))))..)).).....))))).)))).).)))))).))..(((((((.((......)).)))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.......(.(...((.........))...).)..............................)))))))))).))...........]]].)...))))))))))...)))))))((((((()))))))....))))))(.(((((((.((......(((((.((....))])))))...)).)))))))..).....))))))(......((....((((((.......))))))((((....(((...((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]]((((((((.((......((...(((((...((((..(((..(((((.(((((....{{....))))).((..(((((..((((.((((((.((.....))))))))......))))..)))))...))..........)))))...)))...))))(..)....)))))..))..)).)))))))))))).))).....((......))..))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))(((((....((((....))))...)))))(...).......(((((((((.>.((.........))...(((((((.....(((....)))..[....))))))).}((((.(((..(((((((..(((...((...(((((..((....))...)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).[..(((((.....>].)))))..((((((((.(((.((......((((.((((((..(((((.(((((((((.(((((.(....................((................(..............).......................))...........).)))))....((.((((((...].)))))))).....)))))))))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..a.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((....))))....(((.(((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))....)))...))))))).. Cryo-EM structure of Lincomycin bound to the Listeria monocytogenes 50S ribosomal subunit.; 23S ribosomal RNA 8a5i B 114 2.3 RF00001 URS000261774D_169963 36300626 0003735 0005840 169963 cugguaguuauggcgagaaggucacacccguucccauaccgaacacgguaguuaagcuucucugcgccaaugguaguugggggcuucccccugcgagaguaggucgcugccggg <<<<<<<<....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>><<<.......<<.<<<<<...>>>>>.>>.......>>>.>>>>>>>>. ((((((((....((((((((.....((((((...(.....)...))))..))....)))))).))(((.......((.(((((...))))).)).......))).)))))))). Cryo-EM structure of Lincomycin bound to the Listeria monocytogenes 50S ribosomal subunit.; 5S ribosomal RNA 8a63 A 2908 3.1 RF02541 URS000261774E_169963 36300626 0003735 0005840 169963 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Cryo-EM structure of Listeria monocytogenes 50S ribosomal subunit.; 23S ribosomal RNA 8a63 B 114 3.1 RF00001 URS000261774D_169963 36300626 0003735 0005840 169963 cugguaguuauggcgagaaggucacacccguucccauaccgaacacgguaguuaagcuucucugcgccaaugguaguugggggcuucccccugcgagaguaggucgcugccggg <<<<<<<<....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>><<<.......<<.<<<<<...>>>>>.>>.......>>>.>>>>>>>>. ((((((((....((((((((.....((((((...(.....)...))))..))....)))))).))(((.......((.(((((...))))).)).......))).)))))))). Cryo-EM structure of Listeria monocytogenes 50S ribosomal subunit.; 5S ribosomal RNA 8a98 S4 19 2.46 URS00027E5AF8_347515 38722744 347515 gcgcggaguccgcgcacca <<<<<<<.>>>>>>>.... (((((((.))))))).... CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME : snoRNA MUTANT; E-site_tRNA_chain_S4 8a98 S1 1727 2.46 RF01960,RF02542,RF01959,RF00177 URS00027E5AFB_347515 38722744 0003735 0005840 347515 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CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME : snoRNA MUTANT; SSU_rRNA_chain_S1 8a98 1 1579 2.46 RF02543 URS00027E5B01_347515 38722744 0003735 0005840 347515 agaccugaguguggcaggacuacccgccgaacuuaagcauauuacucagcggaggaaaagaaaacaaccgugauucucucagugagcggcgagcgaagagggaacgaacucguugccgaaucgggucuuacaaggccuuaaguuguggcacaaauaucauuucgugguuggugcaggaguggcgaaauucaagcgcaaagcaaacccguugcugaauacaacccuucaugugaguauugagccaaagaagguguuagcccauugagccauaaaccugagcgccucaugaacaagcgaguagcacuguuugggaaugcagugucaaguuggcagguauuugucugccaaaguuaaauacagaguaggaagaccgauagcgaacaaguagcgugagcgaaaguuugaaaagcacuuuggaaagagaguganauagaaccugaagucgugacaaagacaauggaaguaccuccauuucaagagccagaaccagcccuacugcauuauccugucgggggucaaaauccggcgggcaacgaagugcaagagggucuuggugaaaugagcggaguauuugagcuggcacgggcacgcacucuucuccgugaugcuccauguuggcgauggaaauggggugcccccacccgucuugnnacncggaccaaggagunanacagacgcgcaagggaggagauauggccaguacuucucucguacugaaagggagaugcaaaaugcaucuguggugugcacacgucaaauccguuugauuugcccaacaccgaccggcccuccguggguugcguuggagugugccngnuuggacccnanagguggugaacuaugccugaacaaggugaagcccggggaaacccagguggaggccuguagcgaugcugacgugcaaaucgcucguaugauuugggunucgnagcgaaagacucaucgaaccaccuaguagcugguucacaucgaaguuucccucaggauagcuggugcuaguagaaguauugugcgguaaagcgauacuuuaaangugcaaacaaaccggccuuagccaacugcaaggccggaaagaaaagaauuagaggcaccaagugggccuucuucgguaagcngagcaggcgaugcggaaugaaccgcuuagggauauguggcgucaaaacuuaugggcucauucucgauacguaaaggguguugguggccaccggccccgaaaauggangacgcuuaaggccaauuagugaaugcccauuauuccuuugguaagggcggaaacggagaaaguguagcccuuccgauguagauguggccuggagguuaggacgaagcuuauggcgugagccuaagauggaccggccucuagugcanaunuugguuggcgunncaaagaucuaanggagauauacucaacaugcaacguuggauacuggagcggggaaggauuucgugccaacggcacucguacacganuuguucggaaacugagcacaacguuauaucgunuuguuaggaaagugaaguacugaaaaggggcaacagagaaccugggauuauauuccaaaaagaaauugcauguggg ......................<<<<<......<<....>>.......>>>>.>.........<<....>>..<<<<<<......<<.....>>....>>>>>>...<<<...<<<<<..<.<<<<<......>>>>>..>....>>>>>..........<<<<<<...<<<<<<<<.<<<<<......<<<......<<<<.......>>>>.....<<........>>......>>>.<<.......((.....>>)).....>>>>>...>>>..>>>>>.>>>>>>..........<<<<<<<........>>>>>>>......<<<<<........>>>>>..>>>....................................<<....>>................<<<<....>>>>..................................(((..<<<<<<.<<<<<.....<<<<<.<<<<<<<<<...<<<<<..<<<<<<<<<........>>>>>>>>>.....>>.>>>...>>>>>..>>>>........<<<<<.....<<....<<.<..>...>>..>>..>>>>>.....<<<<...>>>>>.....>>>>>>>>>>>..))).<<<<........>>>><<<<<<....<<<<<<<.<<<<<..<<<<..<<.<.........>>>..>>>>...<<....>>..<<<<<.....>>>>>...<<<<<...<<.<<<<<<....>>>>>>.>>....>>>>><<<<<<<<<.....>>>>>>.>>>...>>>>>.>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<.<<<....>>>.>>>.....>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>...<<<<<....<.<<<....>>>.><<<<<<<<<.....<<...<<<<<<<...<<<.....>>.>...>>>>>>>.....<<<<<<<<.<<.....>>>>>>>>>>...........>>...>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>...<<<<......>>>>..<<<<<<<...<<<<<<......[..((.(........(.........<<<.<<<<<<<..>>>>>>>>>>..........>>>.)....).)).].........>>>...>>>>>>>((((.<<<<<.......>>>>.........>>>>>))))....>>>>>..<.<<<<<<<<........<<<<..<<<....>>>.>>>.>.....>>>>>>>>..>.....>>>>>>..............<<<<<<<....................>>>>>>>....................<<<<<....<<.....>>..>>>>>....<<..........<<.<<<<<......>>>>...............<....>......>.>>..........<<<<.........>>....>>.>>........... ......................(((((......(...[..).......)))).).........((....))...((((.......((.]...)).....))))....((((..((((..((.(((((......)))))..)....)))))...........(((((...((((((((.(((((....({((.......((((.......)))).....((........)).......)))[[(...)..((....}]])).....)))))...)))..))))).)))))......)....(((((((........)))))))......(((((........)))))..)))....................................((....)).............(..((.(....).))............)......................((..((((((.((((((....(((((.((((((((....(((((..((((((((..........)))))))).....)).)))....))))..))))........(((.(.....((...(((.(..)...)).)))..).))).....[[[....)))))...).)))))))))))..))..(((..........)))((((.(....(((((((.(((((..(((...((.((.(..)..))))...)))...((....))..(((((.....)))))...(((((...((.((((((....)))))).))....)))))(((((((((.....)))))).)))...))))).)))))))..((.(...((((((.....((((((((((.((((...(((.(((....))).)))...).)))...(((..((.((........)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).).((((((((.....((.(.((((((....(((.....)).)....)))))).....(((.((((.((.....)))))).)))..........)))...))))))).)...((((.((.((.....)).)).))))....(((......)))...((((((....((([[[...(..(..((.(........(.........(((.(((((((()))))))))))..........]]].)....).)).))........)))....))))))((((.((((((.......]]]...).....)))))))))....))))).)(.((((((((.(......((((..(((....))).))).)...).))))))))..).....).))))..............(((((((....................)))))))....................(((((....((.....))..)))))....((......(...((.(.(((......)))............................).))....).....((((.........))....)).))........... CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME : snoRNA MUTANT; LSUa_rRNA_chain_1 8a98 2 1047 2.46 RF02543 URS00027E5B06_347515 38722744 0003735 0005840 347515 ccaacugcagaccguacucaucaccgcaucagguccccaagcauagaaugcucugguacauagagaaangnaaacucagggaagucggcaaanuagaugcguaaguucgcaagaagcauuggcucugagggcaacacaaauugccaacucagaacugnuuacggcggggaauccaacugunuaauuaaaacauagguuugugaugcauccaagugguguauaucgcaaacugauuucugccnagugcucugaaugucaacgugacgagauucaccgacgcgcggguaaacggcgggaguaauaugacucucuuaagguagcnaanugccucnucuuccaauuagagacgcgcaugaanggauuaaugngnuucccucugunccgaguuncuaucuagcgaancgacagucaagggaacggacuugnagggcuaagcggngaaagaagacccunuugaguuugncnccagucuggcucugugcggcgacauguugcuucacuuaucgaaugaagagaccaaugggauuagcguagucuucgggcuaugcaccgucuagguuccaaccgugcuguaaacugaaccaacgggauccggagucuuguuucgagacaucugccagauggggaguuuggcugnggcggcauaucuguuacacgacaacgcaggnnuccuaaggcgagcucagugggaaaucucacguagaacacaagcguaaaagcuugcuugauuaacgauuuccaguangaaucgagacugcgaaagcaaggccngcgauccuuugcgaugaacaaaucauaccanangugucagaauaauuacnacagngauaacuggcuuuggcggccaagucgcugauccuungaugucggnucuuccuaaccuagcgcgacgcuaaggguuggaunnuucacccacugncagggaacgugngcuggguuuagancgucgugagacagguugguuunacccuacuuagcuggaaauugcgagaaaaagauuauccgugcaaagcggagcgguggguaguacuugguacgcucaucacc .......................<<......>>......<<<<<...>>>>>........<<<<....<<<<.<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<......>>>>>..>>>>>>.>>..........<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<...<<....<<<<......>>>>....>>.>>>>>..>>>>>....<.........>...........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>>.>>>>............<<<<<........>>>>>..<<<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<...<<<.<<<<<<..>>>>>>.>>>...<<<<<.....<<<<....<<.....<<<<<<<<<..>>>>>>>>>.>>.....<<<<..>>>>...................<<<...>>>..>>>>...>>>>>.......>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<..>>>>>>.....<<......>>....>>>>>>>...<<...<<<<<.......>>>>>..>>.<<<....>>>.>>.........<<<<<..<<<.......>>>..>>>>>..........>>>>..>>>>>>.......<<.<......<......>...>..>>.......<<<<<.<<<<<<..<<<<<<<...>>>>..>>>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>>>......................<.<.......>.>..<.<<<<<<<.<<<<...>>>>>>>>>>>.>. .......................((......))......((((.....))))........(.((.....(((.((.(.((..(....(.......(((((....(.[..).....)))))((.((((((((.((......)).))..)))))).))..........(((((((((...((.........))...(((((((....((((.....))))......))))))).].(.(.(((..((((((.....((....(((........)))....))..))))..)))))..(.............).........((..........(((((.......)))))..)..)....).)....)).))))))).)..))).).)))))..)).).........[...(.((......].)).)...(((((((..(((.((......((((.(((((...(((((.(((((((...(((.((((((..)))))).)))...(((((.....((((....((.....(((((.((....)).))))).))..(..((((..))))..)................(((...)))..))))...))))).......)))))))..)))))..(((......[)).)(((.(...........].).)))([((...(((((((.(.((((((..))))))...).((][..[.))....))))))).(.(....(((((....{..)))))...))(((....))).)).].].....((.((..(((.......)))..)).))....)}.....)))..)))))).......(.........(......).......)........((((.((((((..(((((((...))))..)))..((.(.....).))......)))))..)...))).)......((((((....))).))).....))..))).))))))).....................................(.(..(.((.((((...)))))).)..).). CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME : snoRNA MUTANT; LSUb_rRNA_chain_2 8a98 4 183 2.46 RF02543 URS000037206E_347515 38722744 0003735 0005840 347515 gugagauugugaagggaucucgcagguaucgugagggaaguaugggguaguacgagaggaacucccaugccgunccucuaguuucugggguuugucgaacggcaagugccccgaagccaucgcacggugguucucggcugaacgccucuaagccagaagccaaucccaagaccagaugcccac <<<<<<<.........>>>>>>>.<<<<<<....<<<<.<<<<<<<<...............>>>>>>>><<<<<...<.<<....<<<<<<<<<......>>>>..>>>>>...>>.>..>>>>>.<<<<..<.<<<<...........>>>>.>..>>>>.>>>>.......>>>>>>... (((((((.........))))))).(((((((...(((..(((((((......(....).....)))))))(((((...(.((....((((((((((....)))))..)))))...)).)..))))).((((....(((.............)))....))))..))).....).))))))... CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME : snoRNA MUTANT; SR2_chain_4 8a98 7 160 2.46 RF00002 URS00027E5AFA_347515 38722744 0003735 0005840 347515 aacgugucgcgauggaugacuuggcuuccuauuucguugaagnacgcaguaaagugcgauaagugguaucaauuncagauucuauuaccgaaucuuugaacgcaaacggcgcaugggagaagcugugucauccccgugcaugccauauucucngugucga .........................................<<<<<<.((.....>>>.....<<<<<......)).........>>>>.>...>>>....<<.....>><<<<<<<.<..<<...>>...>>>>>>>>..................... .........................................((((((.[[.....))).....(((((......]].........)))).)...)))....((.....))(((((((....((...))....)))))))..................... CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME : snoRNA MUTANT; 5.8S_rRNA_chain_7 8a98 8 118 2.46 RF00001 URS00027E5AF9_347515 38722744 0003735 0005840 347515 gaguacgaccacacuugagugaaaacaccauaucccguccgauuugugaaguuaagcacucaaggcucaguuaguacugaggucagugaugacucgggaacccugagugccguacucu <<<<<<<......<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>>><<<<<<......<<<<<..<<....>>.>>>>>.....>>>>>>..>>>>>>>. (((((((.(....((((((((.....((((((...(....)...))))..))....))))))))((((.(......(((((..((....)).))))).....).))))).))))))). CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME : snoRNA MUTANT; 5S_rRNA_chain_8 8a98 5 111 2.46 URS00027E5B07_347515 38722744 347515 uacgucccucuccaaacgagagaacaugcaugggcuggcaugagcggcaugucgguggggcuccgucccgaggcgcugaaccuugaggccugaaaucaugcucagggacac ...<<<<<<<<<.......>>>>....<<<<<<<<.<<.....<<<.........<..<<.......>>..>.>>>....>>.....>>>......>>>>>...>>>>>.. ...(((((((((.......))))....((((((((.((.....(((.(.....)....((.......))....)))....)).....)))......)))))...))))).. CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME : snoRNA MUTANT; SR4_chain_5 8a98 6 71 2.46 URS00005EBAC0_347515 38722744 347515 aucgaaucgccaccuacaagacuggagcuugcucccucgaaggcgccaaguauauucaugaucacaagaca ......<.<<<............<<<<....>>>>......>>>........................>.. .......((((............(((((..)))))(..)..))).......................)... CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME : snoRNA MUTANT; SR6_chain_6 8a98 3 161 2.46 URS00027E5AFF_347515 38722744 347515 gugguaangcgccagguaacaaaucaauccucccacggugagcuuucuuuucaccauaauccaccuugggccuuuuuaucgcguuguucggagcgggggcucaagauugaaaaaugcagccauuguugugaguucugcgcauuaaagcaaaaaccuggggu <<<....>>>.<<<<<<.......<<...<<<.<<.<<<<<<.......>>>>>><...<<.<.<<<<<<<<<<<....<<.......>>....>>>>>>>>>>>.>.>>....>..<....>...>>.>>>...>>...............>>>>>>... (((....))).((((((.......((...(((.(..((((((.......))))))(...((.(.(((((((((((....((.......))....))))))))))).).))....)..(....)....).)))...))...............))))))... CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME : snoRNA MUTANT; SR1_chain_3 8aaf f 3216 2.5 RF02543 URS000268138C_4932 36804914 0003735 0005840 4932 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........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[...........<<.<<<<<<...>>>>>>.>>.............<<<<<<.<<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<.........................<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<....<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>..>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<.<.....>..>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<....>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<..>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<<<<<<<<<..........<<<<<..<<....>>............>>>>>.>>>>>>>.>>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>..>>........<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>.....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<<...<<<<<<<<<<}}}.>>>>>..>>>>>..>>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.(((((.........................(((((((((((((((((((((((.......(((((((......((((.(....).)))).......))))))).....))))).))))))))))........(((....)))....)))))))).....))))).))))).<((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))....))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((((((((((....((.(((((((.....(((....(((..(.((((...((((((.....)))))).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........(((((..........)))))....))....))...(((((........)))))]]((((..(((.(((...((((....)))...(.[[((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....)))...))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((....)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((())))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(.(((((((((((((((..........(((((..((....))............))))).))))))).)))))))).)....((((.....((((..((((........))))..........]]...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Yeast RQC complex in state G; 25S rRNA 8aaf h 121 2.5 RF00001 URS000055688D_4932 36804914 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Yeast RQC complex in state G; 5S rRNA 8aaf i 158 2.5 RF00002 URS00001BF64E_4932 36804914 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Yeast RQC complex in state G; 5.8S rRNA 8aaf x 74 2.5 RF00005 URS000268138D_4932 36804914 0030533 4932 gggcguguggcguagucgagcgcgcucccuuigcaugggagaggucuccgguucgauuccggacucguccgcca <<<<<....<<<<......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>..>>>>>.... ((.((.(..(((.....[..))).(((((.......))))).....(((((..]....)))))).)).)).... Yeast RQC complex in state G; Ala tRNA 8aaf y 73 2.5 RF00005 URS000268138D_4932 36804914 0030533 4932 gggcguguggcguagucagcgcgcucccuuigcaugggagaggucuccgguucgauuccggacucguccgcca <<<<<.<..<<<<.....>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>.>>>>>.... ((.((.(..((((.....)))).(((((.......))))).....(((((.......)))))).)).)).... Yeast RQC complex in state G; Ala tRNA 8af0 C 19 2.43 URS0002616B6E_9606 36048083 9606 gcccgccugucacgcgggc ................... ................... Crystal structure of human angiogenin and RNA duplex; RNA (5'-R(*GP*CP*CP*CP*GP*CP*CP*UP*GP*UP*CP*AP*CP*GP*CP*GP*GP*GP*C)-3') 8af0 D 19 2.43 URS0002616B6E_9606 36048083 9606 gcccgccugucacgcgggc ................... ................... Crystal structure of human angiogenin and RNA duplex; RNA (5'-R(*GP*CP*CP*CP*GP*CP*CP*UP*GP*UP*CP*AP*CP*GP*CP*GP*GP*GP*C)-3') 8agt f 3216 2.6 RF02543 URS000080E1A1_4932 36804914 0003735 0005840 4932 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaugguguuuuguauuucacuggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauagaggguguagaauaagugggagcuucggcgccagugaaauaccacuaccuuuauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[...........<<.<<<<<<...>>>>>>.>>.............<<<<<<.<<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<.........................<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<....<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>..>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<.<.....>..>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<....>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<..>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<<<<<<<<<..........<<<<<..<<....>>............>>>>>.>>>>>>>.>>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>..>>........<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>.....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<<...<<<<<<<<<<}}}.>>>>>..>>>>>..>>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.(((((.........................(((((((((((((((((((((((.......(((((((......((((.(....).)))).......))))))).....))))).))))))))))........(((....)))....)))))))).....))))).))))).<((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))....))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((((((((((....((.(((((((.....(((....(((..(.((((...((((((.....)))))).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........(((((..........)))))....))....))...(((((........)))))]]((((..(((.(((...((((....)))...(.[[((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....)))...))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((....)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((..)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(.(((((((((((((((..........(((((..((....))............))))).))))))).)))))))).)....((((.....((((..((((........))))..........]]...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Yeast RQC complex in state F; 25S rRNA 8agt h 121 2.6 RF00001 URS000055688D_4932 36804914 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Yeast RQC complex in state F; 5S rRNA 8agt i 158 2.6 RF00002 URS00001BF64E_4932 36804914 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Yeast RQC complex in state F; 5.8S rRNA 8agt x 75 2.6 RF00005 URS00026813B4_4932 36804914 0030533 0006412 4932 gggcguguggcguagucgagcgcgcucccuuagcaugggagaggucuccgguucgauuccggacucguccgccaA <<<<<....<<<<......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>..>>>>>..... ((.((.(..(((.....[..))).(((((.......))))).....(((((..]....)))))).)).)).... Yeast RQC complex in state F; A-site Ala aminoacyl-tRNA 8agt y 73 2.6 RF00005 URS0000EEAD03_4932 36804914 0030533 0006412 4932 gggcguguggcguagucagcgcgcucccuuagcaugggagaggucuccgguucgauuccggacucguccgcca <<<<<....<<<<.....>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>..>>>>>.... (((((.(..((((.....)))).(((((.......))))).....(((((.......)))))).))))).... Yeast RQC complex in state F; P-site petidyl-tRNA 8agu f 3216 2.7 RF02543 URS000268138C_4932 36804914 0003735 0005840 4932 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaugguguuuuguauuucacuggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauagaggguguagaauaagugggagcuucggcgccagugaaauaccacuaccuuuauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[...........<<.<<<<<<...>>>>>>.>>.............<<<<<<.<<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<.........................<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<....<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>..>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<.<.....>..>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<....>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<..>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<<<<<<<<<..........<<<<<..<<....>>............>>>>>.>>>>>>>.>>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>..>>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<<...<<<<<<<<<<}}}.>>>>>..>>>>>..>>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.(((((.........................(((((((((((((((((((((((.......(((((((......((((.(....).)))).......))))))).....))))).))))))))))........(((....)))....)))))))).....))))).))))).<((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))....))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((((((((((....((.(((((((.....(((....(((..(.((((...((((((.....)))))).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........(((((..........)))))....))....))...(((((........)))))]]((((..(((.(((...((((....)))...(.[[((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....)))...))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((....)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((..)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(.(((((((((((((((..........(((((..((....))............))))).))))))).)))))))).)....((((.....((((..((((........))))..........]]...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Yeast RQC complex in state E; 25S rRNA 8agu h 121 2.7 RF00001 URS000055688D_4932 36804914 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Yeast RQC complex in state E; 5S rRNA 8agu i 158 2.7 RF00002 URS00001BF64E_4932 36804914 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Yeast RQC complex in state E; 5.8S rRNA 8agu y 73 2.7 RF00005 URS0000EEAD03_4932 36804914 0030533 0006412 4932 gggcguguggcguagucagcgcgcucccuuagcaugggagaggucuccgguucgauuccggacucguccgcca <<<<<....<<<<.....>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>..>>>>>.... (((((.(..((((.....)))).(((((.......))))).....(((((.......)))))).))))).... Yeast RQC complex in state E; P-site tRNA 8agv f 3216 2.6 RF02543 URS000268138C_4932 36804914 0003735 0005840 4932 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaugguguuuuguauuucacuggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauagaggguguagaauaagugggagcuucggcgccagugaaauaccacuaccuuuauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[...........<<.<<<<<<...>>>>>>.>>.............<<<<<<.<<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<.........................<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<....<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>..>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<.<.....>..>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<....>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<..>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<<<<<<<<<..........<<<<<..<<....>>............>>>>>.>>>>>>>.>>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>..>>........<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>.....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<<...<<<<<<<<<<}}}.>>>>>..>>>>>..>>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.(((((.........................(((((((((((((((((((((((.......(((((((......((((.(....).)))).......))))))).....))))).))))))))))........(((....)))....)))))))).....))))).))))).<((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))....))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((((((((((....((.(((((((.....(((....(((..(.((((...((((((.....)))))).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........(((((..........)))))....))....))...(((((........)))))]]((((..(((.(((...((((....)))...(.[[((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....)))...))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((....)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((..)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(.(((((((((((((((..........(((((..((....))............))))).))))))).)))))))).)....((((.....((((..((((........))))..........]]...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Yeast RQC complex in state H; 25S rRNA 8agv h 121 2.6 RF00001 URS000055688D_4932 36804914 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Yeast RQC complex in state H; 5S rRNA 8agv i 158 2.6 RF00002 URS00001BF64E_4932 36804914 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Yeast RQC complex in state H; 5.8S rRNA 8agv x 74 2.6 RF00005 URS0000EEAD03_4932 36804914 0030533 0006412 4932 gggcguguggcguagucgagcgcgcucccuuagcaugggagaggucuccgguucgauuccggacucguccgcca <<<<<....<<<<......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>..>>>>>.... (((((.(..((((....[.)))).(((((.......))))).....(((((..]....)))))).))))).... Yeast RQC complex in state H; Ala tRNA 8agv y 73 2.6 RF00005 URS0000EEAD03_4932 36804914 0030533 0006412 4932 gggcguguggcguagucagcgcgcucccuuagcaugggagaggucuccgguucgauuccggacucguccgcca <<<<<....<<<<.....>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>..>>>>>.... (((((.(..((((.....)))).(((((.......))))).....(((((.......)))))).))))).... Yeast RQC complex in state H; Ala tRNA 8agw f 3216 2.6 RF02543 URS000268138C_4932 36804914 0003735 0005840 4932 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaugguguuuuguauuucacuggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauagaggguguagaauaagugggagcuucggcgccagugaaauaccacuaccuuuauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[...........<<.<<<<<<...>>>>>>.>>.............<<<<<<.<<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<.........................<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<....<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>..>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<.<.....>..>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<....>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<..>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<<<<<<<<<..........<<<<<..<<....>>............>>>>>.>>>>>>>.>>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<<...<<<<<<<<<<}}}.>>>>>..>>>>>..>>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.(((((.........................(((((((((((((((((((((((.......(((((((......((((.(....).)))).......))))))).....))))).))))))))))........(((....)))....)))))))).....))))).))))).<((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))....))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((((((((((....((.(((((((.....(((....(((..(.((((...((((((.....)))))).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........(((((..........)))))....))....))...(((((........)))))]]((((..(((.(((...((((....)))...(.[[((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....)))...))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((....)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((..))))).(..)...((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((((((((((((..........(((((..((....))............))))).))))))).))))))))))....((((.....((((..((((........))))..........]]...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Yeast RQC complex in state D; 25S rRNA 8agw h 121 2.6 RF00001 URS000055688D_4932 36804914 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Yeast RQC complex in state D; 5S rRNA 8agw i 158 2.6 RF00002 URS00001BF64E_4932 36804914 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Yeast RQC complex in state D; 5.8S rRNA 8agw x 74 2.6 RF00005 URS0000EEAD03_4932 36804914 0030533 0006412 4932 gggcguguggcguagucgagcgcgcucccuuagcaugggagaggucuccgguucgauuccggacucguccgcca <<<<<....<<<<......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>..>>>>>.... (((((.(..((((....[.))))..((((.......))))......(((((..]....)))))).))))).... Yeast RQC complex in state D; Ala tRNA 8agw y 73 2.6 RF00005 URS0000EEAD03_4932 36804914 0030533 0006412 4932 gggcguguggcguagucagcgcgcucccuuagcaugggagaggucuccgguucgauuccggacucguccgcca <<<<<....<<<<.....>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>..>>>>>.... (((((.(..((((.....)))).(((((.......))))).....(((((.......)))))).))))).... Yeast RQC complex in state D; Ala tRNA 8agx f 3216 2.4 RF02543 URS000268138C_4932 36804914 0003735 0005840 4932 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaugguguuuuguauuucacuggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauagaggguguagaauaagugggagcuucggcgccagugaaauaccacuaccuuuauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[...........<<.<<<<<<...>>>>>>.>>.............<<<<<<.<<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<.........................<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<....<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>..>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<.<.....>..>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<....>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<..>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<<<<<<<<<..........<<<<<..<<....>>............>>>>>.>>>>>>>.>>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>..>>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<<...<<<<<<<<<<}}}.>>>>>..>>>>>..>>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.(((((.........................(((((((((((((((((((((((.......(((((((......((((.(....).)))).......))))))).....))))).))))))))))........(((....)))....)))))))).....))))).))))).<((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))....))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((((((((((....((.(((((((.....(((....(((..(.((((...((((((.....)))))).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........(((((..........)))))....))....))...(((((........)))))]]((((..(((.(((...((((....)))...(.[[((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....)))...))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((....)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((..)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(.(((((((((((((((..........(((((..((....))............))))).))))))).)))))))).)....((((.....((((..((((........))))..........]]...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Yeast RQC complex in state with the RING domain of Ltn1 in the IN position; 25S rRNA 8agx h 121 2.4 RF00001 URS000055688D_4932 36804914 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Yeast RQC complex in state with the RING domain of Ltn1 in the IN position; 5S rRNA 8agx i 158 2.4 RF00002 URS00001BF64E_4932 36804914 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Yeast RQC complex in state with the RING domain of Ltn1 in the IN position; 5.8S rRNA 8agx x 74 2.4 RF00005 URS000268138D_4932 36804914 0030533 4932 gggcguguggcguagucgagcgcgcucccuuigcaugggagaggucuccgguucgauuccggacucguccgcca <<<<<....<<<<......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>..>>>>>.... ((.((.(..(((.....[..))).(((((.......))))).....(((((..]....)))))).)).)).... Yeast RQC complex in state with the RING domain of Ltn1 in the IN position; Ala tRNA 8agx y 73 2.4 RF00005 URS000268138D_4932 36804914 0030533 4932 gggcguguggcguagucagcgcgcucccuuigcaugggagaggucuccgguucgauuccggacucguccgcca <<<<<.<..<<<<.....>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>.>>>>>.... ((.((.(..((((.....)))).(((((.......))))).....(((((.......)))))).)).)).... Yeast RQC complex in state with the RING domain of Ltn1 in the IN position; Ala tRNA 8agz f 3216 2.6 RF02543 URS000268138C_4932 36804914 0003735 0005840 4932 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaugguguuuuguauuucacuggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauagaggguguagaauaagugggagcuucggcgccagugaaauaccacuaccuuuauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[...........<<.<<<<<<...>>>>>>.>>.............<<<<<<.<<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<.........................<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<....<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>..>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<.<.....>..>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<....>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<..>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<<<<<<<<<..........<<<<<..<<....>>............>>>>>.>>>>>>>.>>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>..>>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<<...<<<<<<<<<<}}}.>>>>>..>>>>>..>>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.(((((.........................(((((((((((((((((((((((.......(((((((......((((.(....).)))).......))))))).....))))).))))))))))........(((....)))....)))))))).....))))).))))).<((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))....))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((((((((((....((.(((((((.....(((....(((..(.((((...((((((.....)))))).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........(((((..........)))))....))....))...(((((........)))))]]((((..(((.(((...((((....)))...(.[[((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....)))...))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((....)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((..)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(.(((((((((((((((..........(((((..((....))............))))).))))))).)))))))).)....((((.....((((..((((........))))..........]]...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Yeast RQC complex in state with the RING domain of Ltn1 in the OUT position; 25S rRNA 8agz h 121 2.6 RF00001 URS000055688D_4932 36804914 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Yeast RQC complex in state with the RING domain of Ltn1 in the OUT position; 5S rRNA 8agz i 158 2.6 RF00002 URS00001BF64E_4932 36804914 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Yeast RQC complex in state with the RING domain of Ltn1 in the OUT position; 5.8S rRNA 8agz x 74 2.6 RF00005 URS000268138D_4932 36804914 0030533 4932 gggcguguggcguagucgagcgcgcucccuuigcaugggagaggucuccgguucgauuccggacucguccgcca <<<<<....<<<<......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>..>>>>>.... ((.((.(..(((.....[..))).(((((.......))))).....(((((..]....)))))).)).)).... Yeast RQC complex in state with the RING domain of Ltn1 in the OUT position; Ala tRNA 8agz y 73 2.6 RF00005 URS000268138D_4932 36804914 0030533 4932 gggcguguggcguagucagcgcgcucccuuigcaugggagaggucuccgguucgauuccggacucguccgcca <<<<<.<..<<<<.....>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>.>>>>>.... ((.((.(..((((.....)))).(((((.......))))).....(((((.......)))))).)).)).... Yeast RQC complex in state with the RING domain of Ltn1 in the OUT position; Ala tRNA 8akn B 1519 2.3 RF00177,RF01959,RF02542,RF01960 URS000081169C_679895 36997646 0003735 0005840 679895 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugccggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngaaccugcgguuggauca .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<......>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<.>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.<...>.>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<..>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((((((......)))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((.)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((((())))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...((((((....))))))....(......)..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Cryo-EM structure of the proline-rich antimicrobial peptide drosocin bound to the terminating ribosome; 16S ribosomal RNA 8akn X 76 2.3 RF00005 URS00005AA258_679895 36997646 0030533 0006412 679895 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>><<<<<<<.....>>>>>>.>...<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).(((((.......))))).....(((((..]....)))))))))))).... Cryo-EM structure of the proline-rich antimicrobial peptide drosocin bound to the terminating ribosome; Phenylalanine-tRNA 8akn Z 76 2.3 RF00005 URS0002681392_679895 36997646 0030533 0006412 679895 ggccccuuagcucagugguuagagcaggcgacuuauaaucgcuuggucgcugguucaaguccagcaggggccacca <<<<<<<...<<<........>>>..<<<<<.......>>>>>.....<<<<.........>>>>>>>>>>>.... (((((((..((............)).(((((.......))))).....((((.........))))))))))).... Cryo-EM structure of the proline-rich antimicrobial peptide drosocin bound to the terminating ribosome; Isoleucine-tRNA 8akn a 2753 2.3 RF02541 URS0002681387_679895 36997646 0003735 0005840 679895 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagcgucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcgcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauauguucuaacguugaccccuaaucgggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<..>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<..>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<..>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(.(((((.....))))..))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(())...)))..))))).))...........]]].)...))))))))))...)))))))(((((((.().)))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((())))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Cryo-EM structure of the proline-rich antimicrobial peptide drosocin bound to the terminating ribosome; 23S ribosomal RNA 8akn b 119 2.3 RF00001 URS0000049E57_679895 36997646 0003735 0005840 679895 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>> ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))) Cryo-EM structure of the proline-rich antimicrobial peptide drosocin bound to the terminating ribosome; 5S ribosomal RNA 8am9 B 1519 2.8 RF00177,RF01959,RF02542,RF01960 URS000081169C_679895 36997646 0003735 0005840 679895 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugccggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.....<<<<<<<<........>>>>>.>>>....>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<.<....>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<..>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>.............>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.....(((.((((........))))..)))....)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....))).....(.((...).))..)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((........)).))))).)).))))))..((((......((((....)))).....)))).....(((((...(....(((.((((.......)))).))).....)....))))).......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((((())))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...((((((....))))))....(......)..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Cryo-EM structure of the proline-rich antimicrobial peptide drosocin bound to the elongating ribosome; 16S ribosomal RNA 8am9 a 2753 2.8 RF02541 URS0002681387_679895 36997646 0003735 0005840 679895 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagcgucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcgcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauauguucuaacguugaccccuaaucgggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<..>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<..>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<<.<<....>>..>>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<..>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((..((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))))))..)))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((.(((.....))).).))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{........)))..))))).))...........]]].)...))))))))))...)))))))((((((((..))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((())))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Cryo-EM structure of the proline-rich antimicrobial peptide drosocin bound to the elongating ribosome; 23S ribosomal RNA 8am9 b 119 2.8 RF00001 URS0000049E57_679895 36997646 0003735 0005840 679895 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>> ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))) Cryo-EM structure of the proline-rich antimicrobial peptide drosocin bound to the elongating ribosome; 5S ribosomal RNA 8am9 X 12 2.8 36997646 679895 uguauguugaua ............ ............ Cryo-EM structure of the proline-rich antimicrobial peptide drosocin bound to the elongating ribosome; mRNA 8am9 Y 76 2.8 RF00005 URS00002905B5_679895 36997646 0030533 0006412 679895 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Cryo-EM structure of the proline-rich antimicrobial peptide drosocin bound to the elongating ribosome; Initiator tRNA 8am9 8 75 2.8 RF00005 URS0000181AEC_679895 36997646 0030533 0006412 679895 gccgaaguggcgaaaucgguagacgcaguugauucaaaaucaaccgugccgguucgaguccggccuucggcacca <<<<<<<..<<<...........>>>.<<<<<<.....>>>>>>...<<<<<.......>>>>>>>>>>>>.... (((((((..(((......[....))).(((((.......)))))...(((((..]....)))))))))))).... Cryo-EM structure of the proline-rich antimicrobial peptide drosocin bound to the elongating ribosome; Leucine tRNA 8ana a 2733 2.1 RF02541 URS0002681387_679895 36997646 0003735 0005840 679895 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagcgucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcgcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauauguucuaacguugaccccuaaucgggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<<..>>>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<..>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<..>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<..<<....>>...>>>>>..>....>>>>>>>>>..>>>>>.......<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<..>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((........)))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((.....((.(.......).))......)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{........)))..))))).))...........]]].)...))))))))))...)))))))((((((((()))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..))))).......((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((())))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Cryo-EM structure of the proline-rich antimicrobial peptide drosocin bound to the 50S ribosomal subunit; 23S ribosomal RNA 8ana b 119 2.1 RF00001 URS0000049E57_679895 36997646 0003735 0005840 679895 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>> ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))) Cryo-EM structure of the proline-rich antimicrobial peptide drosocin bound to the 50S ribosomal subunit; 5S ribosomal RNA 8any AA 954 2.85 RF00177 URS00008F947B_9606 39134711 0003735 0005840 9606 auagguuugguccuagccuuucuauuagcucuuaguaagauuacacaugcaagcauccccguuccagugaguucacccucuaaaucaccacgaucaaaagggacaagcaucaagcacgcagcaaugcagcucaaaacgcuuagccuagccacacccccacgggaaacagcagugauuaaccuuuagcaauaaacgaaaguuuaacuaagcuauacuaaccccaggguuggucaauuucgugccagccaccgcggucacacgauuaacccaagucaauagaagccggcguaaagaguguuuuagaucacccccuccccaauaaagcuaaaacucaccugaguuguaaaaaacuccaguugacacaaaauagacuacgaaaguggcuuuaacauaucugaacacacaauagcuaagacccaaacuggganuagauaccccacuaugcuuagcccuaaaccucaacaguuaaaucaacaaaacugcucgccagaacacuacgagccacagcuuaaaacucaaaggaccuggcggugcuucauaucccucuagaggagccuguucuguaaucgauaaaccccgaucaaccucaccaccucuugcucagccuauauaccgccaucuucagcaaacccugaugaaggcuacaaaguaagcgcaaguacccacguaaagacguuaggucaagguguagcccaugagguggcaagaaaugggcuacauuuucuaccccagaaaacuacgauagcccuuaugaaacuuaagggucgaagguggauuuagcaguaaacugagaguagagugcuuaguugaacagggcccugaagcgcguacacaccgncngucacccuccucaaguauacuucaaaggacauuuaacuaaaaccccuacgcauuuauauagaggagacaagucguaacaugguaaguguacuggnnagugcacuuggacgaacc ..((((..<<<<<<.)))).<<<<<<.<<..<<<<<<<<..<.<<<.<<<..<......>......<<.......<<<<.<..<<<.....>>>.>..>>>>..<<<<....<<...<<<....>>>..>>......>>>>.<<...>>.>>.<<<....>>>.....>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>.....<<<<<<<<.....(((.....((.>>>)).......)))..>>>>>..>>.>>>>>>....<<<((.....<<<<..<<<<...............<<<<<<......<<<.<<<.<<<......>>>..>>>.>>>.............<<....>>.>>>>>>.....>>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<.<<<<<......))..>>>>>.>.>>>.<<.......<<<<....>>>>.....>>..>>>>>><<<<<.<<<<<<<...<<<.<<<<<..<<<<<<<<<<.....<<........>>..........<<<<<<<.......<<.<<<..<<<<<<.......<<..<<<<<.....>>>.......>>..>>.....<<<....>>>.........>>>...>>>>>>>>....>>>>>>>..>>.>>>>>>>>.....<<<<.....>>>>.....<....<<<<<<<.......>>>>>>>....>.....>>>>>.....<<<<<<<.........>>>>>>>.....>>>...>>>>>>>>>>.>>....<..<<.<...<<<<<<..<<<<<......<<<...<<<.....>>>..>>>.......>>>>>.>>>>>>....>.>>...>.....<<<<<<<<<....>>>>>>>>>......... [.[[[[..(((((..]]]]]((((((.((..((((((((..(.(((.(((..(......)......(((......((((.(..(((.....))).)..))))..((((....((..((((....))).)))......)))).((...))))).(((....))).....)))))))......(.(((...(((((....)))).))))).)).)))))).....((((([[[.....(((.....((.]]])).......)))..)))))..)).))))))....((([[...(.((((...(((...............(((((((.....(((.(((.((........))..))).))).....).....(.((....))))))))).....)))....))))....((((((...((...((((.........))))...))))))))......{...(.(((((......]]..))))).))))).((.......((((....)))).....))...)))))(((((.(((((((...(((.(((((..((((((((((.....((........))..........(((((((.......((.(((...((((((.(....((..(((((.....))).......))..)).....(((....))).....).).)))...)).)))))....)))))))..)).)))))))).(...((((.....)))).....(....(((((((.......)))))))....)..)..))))).....(((((((.........))))))).....)))...)))))))))).))..(.(..((.(...((((((...((((..((..(((....((.....))...)))..).)..))))..))))))....).))...)..)..(((((((((....)))))))))}........ Human mitochondrial ribosome in complex with LRPPRC, SLIRP, A-site, P-site, E-site tRNAs and mRNA; 12S mitochondrial rRNA 8any Aw 68 2.85 URS0002681443_9606 39134711 9606 ugguauauaguuuaaacaaaacuaaugauuaacacucauuaaauuaugauaaucauauuuaccaucca <<<<<....<<<<.....>>>><<<<<<.......>>>>>>...<<<<<...>>>>>..>>>>>.... (((((.(..(((.......)))((((((.......))))))...(((((...)))))).))))).... Human mitochondrial ribosome in complex with LRPPRC, SLIRP, A-site, P-site, E-site tRNAs and mRNA; A/A-tRNA 8any Ax 70 2.85 RF00005 URS0002681461_9606 39134711 0030533 0006412 9606 uagggaauaguuuaaaaaacaucugacuuacauucagaagauggagguucaauuccuccuucccuaacca <<<<<<<..<<<<...>>>>.<<<<<.......>>>>>....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...)))).(((((.......)))))....(((((.......)))))))))))).... Human mitochondrial ribosome in complex with LRPPRC, SLIRP, A-site, P-site, E-site tRNAs and mRNA; P/P-tRNA 8any Ay 70 2.85 RF00005 URS00021ED990_9606 39134711 0030533 0006412 9606 uagggaauaguuuaaaaaacagcugacuuucaaucagcagauggagguucaauuccuccuucccuaacca <<<<<<<..<<<<...>>>>.<<<<<.......>>>>>....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...)))).(.(((.......))).)....(((((.......)))))))))))).... Human mitochondrial ribosome in complex with LRPPRC, SLIRP, A-site, P-site, E-site tRNAs and mRNA; E/E-tRNA 8any A 1558 2.85 RF02541 URS00021ED93A_9606 39134711 0003735 0005840 9606 gcuaaaccuagccccaaacccacuccaccuuacuaccagacaaccuuagccaaaccauuuacccaaauaaaguauaggcgauagaaauugaaaccuggcgcaauagauauaguaccgcaagggaaagaugaaaaauuauaaccaagcauaauauagcaaggacuaaccccuauaccuucugcauaaugaauuaacuagaaauaacuuugcaaggagagccaaagcuaagacccccgaaaccagacgagcuaccuaagaacagcuaaaagagcacacccgucuauguagcaaaauagugggaagauuuauagguagaggcgacaaaccuaccgagccuggugauagcugguuguccaagauagaaucuuaguucaacuuuaaauuugcccacagaacccucuaaauccccuuguaaauuuaacuguuaguccaaagaggaacagcucuuuggacacuaggaaaaaaccuuguagagagaguaaaaaauuuaacacccauaguaggccuaaaagcagccaccaauuaagaaagcguucaagcucaacacccacuaccuaaaaaaucccaaacauauaacugaacuccucacacccaauuggaccaaucuaucacccuauagaagaacuaauguuaguauaaguaacaugaaaacauucuccuccgcauaagccugcgucagauuaaaacgaacugacaauuaacagcccaauaucuacaaucaaccaacaagucauuauuacccucacugucaacccaacacaggcaugcucauaaggaaagguuaaaaaaaguaaaaggaacucggcaaaucuuaccccgccuguuuaccaaaaacaucaccucuagcaucaccaguauuagaggcaccgccugcccagugacacauguuuaacggccgcgguacccuaaccgugcaaagguagcauaaucacuuguuccuuaanuagggaccuguaugaauggcuccacgaggguucagcugucucuuacuuuuaaccagugaaauugaccugcccgugaagaggcgggcauaacacagcaagacgagaagacccuauggagcuuuaauuuauuaaugcaaacaguaccuaacaaacccacagguccuaaacuaccaaaccugcauuaaaaauuucgguugnggcgaccucggagcagaacccaaccuccgagcaguacaugcuaagacuucaccagucaaagcgaacuacuauacucaauugauccaauaacuugaccaacggaacaaguuacccuagggauaacagcgcaauccuauucuagaguccauaucaacaauaggguuuacgaccucgauguuggaucaggacaucccgauggugcagccgcuauuaaagguucguunnuucaacgauuaaaguccuacgugaucugaguucagaccggaguaauccaggucgguuucuaucuacuuucaaauuccucccuguacgaaaggacaagagaaauaaggccuacuucacaaagcgccuucccccguaaaugauaucaucucaacuuaguauuauacccacacccacccaagaacaggguuugu <<<.......<<<<.....................................<......>...............<<.....>>.............>>.>>.............<<....>>......................>>>...........<<<.......>>>...<.<........>.>.<<<<<<.........<<<.<<..<<....>>...>>.>>>...<<.<...<<<<.<.....<<<<<.<<<..<<<.....>>>...<<<..<<<<........>>>>.>>>....>>>.>>>>>...<<.......>>......>.>>>>......>.>>..<<<<<<....<<<<....>>>><<<.<<<<<<<<<<.....<<..........>>.....>>>>>>>>>>..>>>.<<<<<<<<<<......>>>>>>>>>>...<<<......>>>....<<<.<<<...<..............<....<<<.........>>>....>.......<<<......>>>....................................>...>>>>>>........>>>>>>...<<<<<......>>>>>.........>>>>>><......<<..<<<....>>><<<<..<<<<........<<<<<..<.....>..>>>>>......<<<...<<<<.......................>>>>.......>>>.....<<......>>.>>>>.....>>>>..<<<<...<<<<<<<<.<<................<<<<<<..<<<.........>>>...<<<<<<.............>>>>>>....<<<.<<<..<<<<<....>>>..>>>>><<<<<<......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>....>>.>>>>........>>.>>>>>>>>>>>>.>>.....>.....<<<<<........>>>>>.......<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<....<<<........<<<....>>>.......>>>......>>>>>>>>>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<.....<<<..<<<<.....>>>>..>>>...........>>.........<<<....>>>............>>>>..>>>>>>.......<<<..<.<<<<<<...<<.......>>...>>>>>>...>.>>.>.......<<<<<.<<<<<<..<<.<<<<<<......>>>>>>...>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>...<.<<<.<<<.................>>>.>>><<<<<...<<<....>>>.>>>>>......<<<................>>>......>..........<<<<.......>>>>.... ((.....(..((((.....................................(...[..).........(.....((.]...))....)........)).)).............((....))....)..................)).........(.(((.......))).[.(.(........).).((((((.........(((.((..((....))...)).)))...((.(...((((.(.....(((((.((((.(((....[)))...(((..((((.......{)))).)))..).))).))))).(.((.......))...)..).))))......).))..((((((....((((....)))).((.((((((((((.....((..........)).....))))))))))..))..((((((((((......))))))))))...(((......)))....(((.(((...(..............(.(..(((.........)))..).)....(..(((......))))...................................)...))))))........))))))...(((((......))))).........))))))(......((..(((....)))(((...((((......(.(((((.((.....)).)))))......(((...((((...............(..)....)))).......))).)...((......)).))))......)))..((((....(((((((.((..(....(........((((((.].((.........))....((((((.............))))))....(((.(((..(((((....)))..)))))(((((........)))))........((..........(((((.......)))))..)..)....)))....)).))))....)..))).))))))).)))).)).....)).{..(((((.....]}.))))).......((..(((.((......((((.((((((..(((((.((((((((....(((........(((....))).......)))......)))))))))))))..(((......[)))((((((..........]))))))(.((.....((...(((....[..)))...))...........)).........(((....))).....)].....))))..))))))......((((..(.((((((.(.((.......)))..))))))...).)).).)......(.((.((((((..((.((((((......))))))...)).(((((.....))))).....)))))..)...))..).....(((((((....))).))))..}.))..))).))...(.(((.(((......(....).....))).)))(((((...(((....))).)))))......(((................)))......).........(((((.......))))..). Human mitochondrial ribosome in complex with LRPPRC, SLIRP, A-site, P-site, E-site tRNAs and mRNA; 16S mitochondrial rRNA 8any Az 42 2.85 39134711 9606 uuuaagugguuguuuauaaaaaaauuuacuuacaucaccuuc .......................................... .......................................... Human mitochondrial ribosome in complex with LRPPRC, SLIRP, A-site, P-site, E-site tRNAs and mRNA; mRNA 8ap4 Z 71 3.0 RF00005 URS00002905B5_83333 36370110 0030533 0006412 83333 gcgggguggagcagccgguagcucgucgggcaacccgaaggucgucgguucaaauccggcccccgcaacca <<<<<<..<<<<........>>>>.<<<<<...>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((.....[..)))).(((((...))))).....(.(((..]....))).)))))))..... Structure of Escherischia coli heat shock protein Hsp15 in complex with ribosomal 50S subunits bearing peptidyl-tRNA; P-tRNA 8ap4 a 2750 3.0 RF02541 URS000261775A_83333 36370110 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagcgucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcgcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>...>.>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<..<<<.....>>>...>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<..>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<..>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.......<<<<<<.<<....>>..>>>>>>.......>>>>>>>>>..>>>>><<<<<......>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<..>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>.(<<...<<<<<<<...<<<<<<.......>>>>>>.....<<)..(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.)))....(((((((...(((]]]..].))).......)))))).).)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))..(((((((..((((((((((.....(((...(((.((((...((.((((.....))))..))...)))).)))..)).).....)))))).)))..)))))))).....(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{........)))..))))).))...........]]].)...))))))))))...)))))))((((((((()))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).(((.......)))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(.(((......))).)........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((())))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).).....((.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..))....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Structure of Escherischia coli heat shock protein Hsp15 in complex with ribosomal 50S subunits bearing peptidyl-tRNA; 23S rRNA 8ap4 b 119 3.0 RF00001 URS0000049E57_83333 36370110 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>> ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))) Structure of Escherischia coli heat shock protein Hsp15 in complex with ribosomal 50S subunits bearing peptidyl-tRNA; 5S rRNA 8apn A1 109 3.1 URS000261776F_353565 36253367 353565 ugugaccguuagcgcauaguacaguaauggaagugcauaaaccaaauuaaaggcuuaaauuaaaaauaaaauggcuggugcaauggcacaaaaaauaagaaaguuuaaa <<<<.<<..............<<....>>....<<<<....<<<...........................>>>....>>>>..>>>>>>................... ((((.((..............((....))....((((....(((...........................)))....))))..))))))................... Structure of the mitochondrial ribosome from Polytomella magna with tRNA bound to the P site; mtLSU-1 8apn A2 81 3.1 URS000261777F_353565 36253367 353565 aauaaauaaguuuaauaccuuuugcagcauggaccagcgauuaaaugccgguaauuagcaaaguuaaacuaacgaaaaaua ..<<<<<..>>>>>...<.<........>.>........................<<<<...>>>>............... ..((((....))))...(.(........).)........................((((...))))............... Structure of the mitochondrial ribosome from Polytomella magna with tRNA bound to the P site; mtLSU-2 8apn A3 207 3.1 RF02541 URS000261778D_353565 36253367 0003735 0005840 353565 uuacaggcauuuaauucgaagcauagcgagcuaacguuuagcagguuugcauaaauuaaauauauuaaaaaagcaagaccgcaaagguuucuguagcaauagaaucuugugacuuaacguuaggggcgauaaaccaaucacgcuauggcauagcuaaguuucugcgaaauauauuuagguauagcuuaaaaaacuuuauagauaaaa ..............<<.<..<<<<<<<.....<<<<<<.<<..<<<<<<<.....<<<<.....>>>>....>>>>.>>>...<<<..<<<<........>>>>.>>>....>>.>>>>>>...<<.......>>......>>>>>>...>..>.>>............<<<<<....>>>>>........................ ..............((.(...((((((.....((((((.(((.(((((((.....((((.....))))....)))).)))...(((..((((........)))).)))..).)).)))))).(.((.......))...)..))))))......).))............(((((....)))))........................ Structure of the mitochondrial ribosome from Polytomella magna with tRNA bound to the P site; mtLSU-3 8apn A4 73 3.1 URS000261775F_353565 36253367 353565 uaagucagacgcaaagcuacaagguuucgcgucaaaaggaaaaaaguccgccagcgaggcuaagguacauaaa .......<<<<<.<<<<......>>>>.>>>>>....<<<......>>>........................ .......(((((.((((......)))).)))))....(((......)))........................ Structure of the mitochondrial ribosome from Polytomella magna with tRNA bound to the P site; mtLSU-4 8apn A5 136 3.1 RF02541,RF02540 URS0002617779_353565 36253367 0003735 0005840 353565 uaaugugcaccaaacaaccaggaggugggcuuggaagcagccauccuuugaagaaagcguaauagcucugcuuuuuguguaacauuacacuacacgcagaaaauaaaagccgaagcucgcuuguucaguuaaauau <<<<<<<<<<.....<<.....<<...<<<<.......>>>>...>>........<<<......>>>......>>.>>>>.>>>>>>................................................. .(((((((((.....((.....(((..(((.........)))..))).....(...((......)).).....)).)))).))))).................................................. Structure of the mitochondrial ribosome from Polytomella magna with tRNA bound to the P site; mtLSU-5 8apn A6 109 3.1 URS0002617763_353565 36253367 353565 gcagguagcagaacguucuauauaauagaauugcuaaugcugguauaaguaacuauguaaaaauacagcuaagcuaaagguuuugcgcaacagugaaacgauaaaguaa .............<.<<<<<<...>>>>>>..>.......................<<......>>.................<<.....>>................. .............(.((((((...))))))..).......................(((....))).................((.....))................. Structure of the mitochondrial ribosome from Polytomella magna with tRNA bound to the P site; mtLSU-6 8apn A7 534 3.1 RF02541 URS0002617777_353565 36253367 0003735 0005840 353565 aaucguaccgcaaaccaacacagguuaguuauuguaaaggcuguauaaaaccaggauaaaggaacucggcaaaauagguuauguuuucguacaaaaccacaacaaaaguagugacuguuuaccaaaaacacaagacucugcuaacacuuauaguggaaguauagugucugauaccugcccaaaggcaaagcaaacggcagcuguaacucuaacggcucuaagguagcaaaauuccauggcauuuaaaugaugucccgcaugaaugguauaacaacuucuuaacugucucuauucuggauuaggcgaacuuuaaaugcuugugcagaugcaggcuagcuaacaagggacgaagagacccuaugcagcuuuagggcagguuauuauucaauaaacuaccuuuuuucugggacggacgcucuuauuaaagaaacaagagugagcaaugguuuuuacuaauuauaaaaaagaaaagcuuaacugcaauacaaacaauuaaagcaggggcauugucggcaauaaugcauugaagaaaua ..............<<......>>...................<<.....<<<<<<<<.<<.........<.....<<<<.<<<......>>>.>>>>.......<<<.<<<<..<<<.........>>>..<<<<.<<.....<<<.....>>>.......>>.>>>>.<<<<<.<<<.....<<...>>....>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>.>>>...>..>>.>>>>>>>>..>>..............<<<<<........>>>>>....................................<<<<..<<<<<<<....>>>>.>>>.>>>>...<<<.....>>>.<<<<<<...........>>>>>>..<<...<<<<<<..<.....((......>.>>>>>>...<<<<..<<........>>..>>>>.<<<...>>>.>>.))................. ..............((......)).........[.........((.(...((((((((.((..(....(.......(((..(((..{...)))..))).].....(((.((((...((.........))...((((.((.....(((.....))).......)).)))).}((((.(((.....((...))....)))(((((.........)))))........((..........((((((.....))))))..)..)....))))...)).)).)))..)..))).)))))))).)))...........[..(((((......].)))))....................................((((..(((((((....)))).))).))))...((......[))..(((((..........])))))...((...(((((((.((....[[.....)))))))))...((((..((........))..)))).(((...))).)).]]................. Structure of the mitochondrial ribosome from Polytomella magna with tRNA bound to the P site; mtLSU-7 8apn A8 350 3.1 RF02541 URS0002617774_353565 36253367 0003735 0005840 353565 cguucuucaaccaacggaauaaagcuacgcuagggauaacaggcuuauucgcucacagaguuuuaucgacgagcgcgguuggcaccucgauguuggaucaccgcuuccuguagcugcaaacgguuauaaggguuagacuguucgucugauaaugcgguacgugaucugaguucaaagcgucguaagacaguuugguuucuaucuuuguuagcauaaguauuacggcguuguguacaguacgaaaggauuguugcacaauuaaccaauaguuuaaagagcaacguuaauaaaccggaaaacuuuuaacugcacugugcaguugcaggcaaagcaauguucagcuaaaaaaa .........................................<<<<.<..<<<<<...<<......>>...>>>>>....>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>.....................<<<<.<<.<<<...<<<<<<.................>>>>>>.<<<<<.....<<.......>>...>>>>>....>>>..>>>>>>...................<<..<<<......>>>...>>........ ........................................(((((.(..(((((...((......))...)))))....)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).)))).....................((((..(.(((...(((((((....(....)....).)))))).(((((...(.((.......)).).)))))....))).)..))))...................((.((((......))).).))........ Structure of the mitochondrial ribosome from Polytomella magna with tRNA bound to the P site; mtLSU-8 8apn B1 102 3.1 URS0002617782_353565 36253367 353565 cauaggguuugguuuuugcccagccuuuagcuuagcguuaagcuuauacaugcuagccuaaaagacggcgcacaggugcauauuuuguaagcauguaaaaua ....<<<<.........>>>>..................................<<<........>>>................................. ....((((.........))))..................................(((........)))................................. Structure of the mitochondrial ribosome from Polytomella magna with tRNA bound to the P site; mtSSU-1 8apn B2 210 3.1 RF00177 URS0002617758_353565 36253367 0003735 0005840 353565 aaaguguacuuuauaaagucauuguauugcuuacaaauaacuaggcaguugggucggcugcuauacuauagcgccccaagccugauaauuagcuaggcguaacagcggcaagccacaguagcacauaaaaauugcuaccguuaacgcagcaguaagaaagauuggacaauagcuuaagggcagauccagguaagcgcuaaaaucuuugug ..<<<<.<<<<....>>>>>>>>.............<<.....<<<..<<<<<.<<...............>>.>>>>>>>>.....>>..<<<..<<......>>....>>>....<<<<<<.........>>>>>><<<..>>>.................<<<...<.<<<....>>>..>>>>....................... ..((((.(((......))))))).............((.....(((..(((((.((...............)).)))))))).....))..(((..((......))....)))....((((((.........))))))(((..)))...............(.(((...(.(((....)))..)))))...................... Structure of the mitochondrial ribosome from Polytomella magna with tRNA bound to the P site; mtSSU-2 8apn B3 379 3.1 RF00177,RF01959,RF02542,RF01960 URS0002617754_353565 36253367 0003735 0005840 353565 gagcuccggcuaauugugugccagcagccgcgggaauacacaaggggccaguuuaagguuaaaacaaggcaacgguguuuaaaaacuggaaaugcgccuaaaauagcuuaaugcguuggaguaaggguuaaaucuguaaaaaccuugcagaaagccuuaaaguaaaagcagcuauucaugcccauaaaacagucuauaaacgagagcugcgguagcaaaacggauuagauacccguguagucccagccguaaauuauuuauuaaauuaaagcgccuagcgauauugccuauggcacuaaacuagggaaucugacagcauuaaacugacgcgguggagcauacuucuuaauuugauaauacgcaaaaacauuaccacgau ..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>...................<<<......<<<<<...<<.....<<<.<<.<..<<<<<<<<..<<<...<<....<<<......>>>.......>>..>>>..>>.................>>>>>>.>.>>.>>>......>>...>>>>>....<<<<.<...<<...<<<<.<.....>.>>>>...>>>.>>>>.........<<<<......>>>>..>>>.<<......<<<<...>>>>.....>>.................................................<<........>>................ (.((((([[[...(((((.....((.]]])).......)))))))))))..................(((....(.((((....((.....(((.((.(..((((((((..(((...((....((........)).......))..)))..)).................)))))).).)).)))......))....))))....((((.(...((...((((.........))))...))).)))).........((((......)))).)))).((......((((...)))).....)).................................................((........))................ Structure of the mitochondrial ribosome from Polytomella magna with tRNA bound to the P site; mtSSU-3 8apn B4 337 3.1 RF00177,RF01960,RF02542,RF01959 URS000261777E_353565 36253367 0003735 0005840 353565 aaaccacgguauugcauggcugauauauaauccauacaaaggauauaaccaaguagcauggucuuauauugugggcuggcggugugcuacaaguaacaaaaaguacaaccggauuaauuacugaaaucauaaauauaaagagggaaucgcuaguaaucuuuauuauaacauaaaggugaaccaguuuagugugcacacacugcccgucacauccgggaaaaccacaaagcccuaaguuuguauaguguuuaauaaaccaauucaaacauaagcuuauuguuaacaaggaugaagucguaacaagguuugcguaggggaaccugcucaagauuaugcu .......<<.<<...<<<<<<.....<<<.<<<.......>>>>>>.....>>>..>>>.>>>>...............................<<.....>>.....<....<<.<<<.........>>>.>>....>...............<<<<<<<<......>>>>>>>>........................<..<<.<.<<<<<..<..<<<.<..<<<<....<<<<<<.<<.<.<<.......>>>.>>.>>>>>.>..>>>>.>.>>>..>..>>>>>..>.>>...>.....<<<.<<<<<....>>>>>.>>>......... .......((.(((...((((((....(((.(((.......))))))...).)))..)).))))).........................(.....((.....)).....(....((.(((.........))).))....)..)............(((((((((...).))))))))......................(.(..((.(.(((((..(...((.....(((.....(((((.((.(.((.......))).)).)))))....)))....))...)..)))))..).))...)..)..(((.(((((....))))).)))......... Structure of the mitochondrial ribosome from Polytomella magna with tRNA bound to the P site; mtSSU-4 8apn C1 73 3.1 RF00005 URS0000334CEC_353565 36253367 0030533 0006412 353565 aaauacauagcuuagcggcuaaagcacugguuucauaagccagcuaucaacaguucgagucuguuuguauuua <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>. (((((((..(((.....[....))).(((((.......))))).....(((((..]....)))))))))))). Structure of the mitochondrial ribosome from Polytomella magna with tRNA bound to the P site; P-site tRNA 8apo A1 109 3.2 URS000261776F_353565 36253367 353565 ugugaccguuagcgcauaguacaguaauggaagugcauaaaccaaauuaaaggcuuaaauuaaaaauaaaauggcuggugcaauggcacaaaaaauaagaaaguuuaaa <<<<.<<..............<<....>>....<<<<....<<<...........................>>>....>>>>..>>>>>>................... ((((.((..............((....))....((((....(((...........................)))....))))..))))))................... Structure of the mitochondrial ribosome from Polytomella magna with tRNAs bound to the A and P sites; mtLSU-1 8apo A2 81 3.2 URS000261777F_353565 36253367 353565 aauaaauaaguuuaauaccuuuugcagcauggaccagcgauuaaaugccgguaauuagcaaaguuaaacuaacgaaaaaua ..<<<<<..>>>>>...<.<........>.>........................<<<<...>>>>............... ..((((....))))...(.(........).)........................((((...))))............... Structure of the mitochondrial ribosome from Polytomella magna with tRNAs bound to the A and P sites; mtLSU-2 8apo A3 207 3.2 RF02541 URS000261778D_353565 36253367 0003735 0005840 353565 uuacaggcauuuaauucgaagcauagcgagcuaacguuuagcagguuugcauaaauuaaauauauuaaaaaagcaagaccgcaaagguuucuguagcaauagaaucuugugacuuaacguuaggggcgauaaaccaaucacgcuauggcauagcuaaguuucugcgaaauauauuuagguauagcuuaaaaaacuuuauagauaaaa ..............<<.<..<<<<<<<.....<<<<<<.<<..<<<<<<<.....<<<<.....>>>>....>>>>.>>>...<<<..<<<<........>>>>.>>>....>>.>>>>>>...<<.......>>......>>>>>>...>..>.>>............<<<<<....>>>>>........................ ..............((.(...((((((.....((((((.(((.(((((((.....((((.....))))....)))).)))...(((..((((........)))).)))..).)).)))))).(.((.......))...)..))))))......).))............(((((....)))))........................ Structure of the mitochondrial ribosome from Polytomella magna with tRNAs bound to the A and P sites; mtLSU-3 8apo A4 73 3.2 URS000261775F_353565 36253367 353565 uaagucagacgcaaagcuacaagguuucgcgucaaaaggaaaaaaguccgccagcgaggcuaagguacauaaa .......<<<<<.<<<<......>>>>.>>>>>....<<<......>>>........................ .......(((((.((((......)))).)))))....(((......)))........................ Structure of the mitochondrial ribosome from Polytomella magna with tRNAs bound to the A and P sites; mtLSU-4 8apo A5 136 3.2 RF02541,RF02540 URS0002617779_353565 36253367 0003735 0005840 353565 uaaugugcaccaaacaaccaggaggugggcuuggaagcagccauccuuugaagaaagcguaauagcucugcuuuuuguguaacauuacacuacacgcagaaaauaaaagccgaagcucgcuuguucaguuaaauau <<<<<<<<<<.....<<.....<<...<<<<.......>>>>...>>........<<<......>>>......>>.>>>>.>>>>>>................................................. .(((((((((.....((.....(((..(((.........)))..))).....(...((......)).).....)).)))).))))).................................................. Structure of the mitochondrial ribosome from Polytomella magna with tRNAs bound to the A and P sites; mtLSU-5 8apo A6 109 3.2 URS0002617763_353565 36253367 353565 gcagguagcagaacguucuauauaauagaauugcuaaugcugguauaaguaacuauguaaaaauacagcuaagcuaaagguuuugcgcaacagugaaacgauaaaguaa .............<.<<<<<<...>>>>>>..>.......................<<......>>.................<<.....>>................. .............(.((((((...))))))..).......................(((....))).................((.....))................. Structure of the mitochondrial ribosome from Polytomella magna with tRNAs bound to the A and P sites; mtLSU-6 8apo A7 534 3.2 RF02541 URS0002617777_353565 36253367 0003735 0005840 353565 aaucguaccgcaaaccaacacagguuaguuauuguaaaggcuguauaaaaccaggauaaaggaacucggcaaaauagguuauguuuucguacaaaaccacaacaaaaguagugacuguuuaccaaaaacacaagacucugcuaacacuuauaguggaaguauagugucugauaccugcccaaaggcaaagcaaacggcagcuguaacucuaacggcucuaagguagcaaaauuccauggcauuuaaaugaugucccgcaugaaugguauaacaacuucuuaacugucucuauucuggauuaggcgaacuuuaaaugcuugugcagaugcaggcuagcuaacaagggacgaagagacccuaugcagcuuuagggcagguuauuauucaauaaacuaccuuuuuucugggacggacgcucuuauuaaagaaacaagagugagcaaugguuuuuacuaauuauaaaaaagaaaagcuuaacugcaauacaaacaauuaaagcaggggcauugucggcaauaaugcauugaagaaaua ..............<<......>>...................<<.<...<<<<<<<<.<<.........<.....<<<<.<<<......>>>.>>>>.......<<<.<<<<..<<<.........>>>..<<<<.<<.....<<<.....>>>.......>>.>>>>.<<<<<.<<<.....<<...>>....>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>.>>>...>..>>.>>>>>>>>.>>>..............<<<<<........>>>>>....................................<<<<..<<<<<<<....>>>>.>>>.>>>>...<<<.....>>>.<<<<<<...........>>>>>>..<<...<<<<<<..<.....((......>.>>>>>>...<<<<..<<........>>..>>>>.<<<...>>>.>>.))................. ..............((......)).........[.........((.(...((((((((.((..(....(.......(((..(((..{...)))..))).].....(((.((((...((.........))...((((.((.....(((.....))).......)).)))).}((((.(((.....((...))....)))(((((.........)))))........((..........((((((.....))))))..)..)....))))...)).)).)))..)..))).)))))))).)))...........[..(((((......].)))))....................................((((..(((((((....)))).))).))))...((......[))..(((((..........])))))...((...(((((((.((....[[.....)))))))))...((((..((........))..)))).(((...))).)).]]................. Structure of the mitochondrial ribosome from Polytomella magna with tRNAs bound to the A and P sites; mtLSU-7 8apo A8 350 3.2 RF02541 URS0002617774_353565 36253367 0003735 0005840 353565 cguucuucaaccaacggaauaaagcuacgcuagggauaacaggcuuauucgcucacagaguuuuaucgacgagcgcgguuggcaccucgauguuggaucaccgcuuccuguagcugcaaacgguuauaaggguuagacuguucgucugauaaugcgguacgugaucugaguucaaagcgucguaagacaguuugguuucuaucuuuguuagcauaaguauuacggcguuguguacaguacgaaaggauuguugcacaauuaaccaauaguuuaaagagcaacguuaauaaaccggaaaacuuuuaacugcacugugcaguugcaggcaaagcaauguucagcuaaaaaaa .........................................<<<<.<..<<<<<...<<......>>...>>>>>....>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>.....................<<<<.<<.<<<...<<<<<<.................>>>>>>.<<<<<.....<<.......>>...>>>>>....>>>..>>>>>>...................<<..<<<......>>>...>>........ ........................................(((((.(..(((((...((......))...)))))....)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).)))).....................((((..(.(((...(((((((....(....)....).)))))).(((((...(.((.......)).).)))))....))).)..))))...................((.((((......))).).))........ Structure of the mitochondrial ribosome from Polytomella magna with tRNAs bound to the A and P sites; mtLSU-8 8apo B1 102 3.2 URS0002617782_353565 36253367 353565 cauaggguuugguuuuugcccagccuuuagcuuagcguuaagcuuauacaugcuagccuaaaagacggcgcacaggugcauauuuuguaagcauguaaaaua ....<<<<.........>>>>..................................<<<........>>>................................. ....((((.........))))..................................(((........)))................................. Structure of the mitochondrial ribosome from Polytomella magna with tRNAs bound to the A and P sites; mtSSU-1 8apo B2 210 3.2 RF00177 URS0002617758_353565 36253367 0003735 0005840 353565 aaaguguacuuuauaaagucauuguauugcuuacaaauaacuaggcaguugggucggcugcuauacuauagcgccccaagccugauaauuagcuaggcguaacagcggcaagccacaguagcacauaaaaauugcuaccguuaacgcagcaguaagaaagauuggacaauagcuuaagggcagauccagguaagcgcuaaaaucuuugug ..<<<<.<<<<....>>>>>>>>.............<<.....<<<..<<<<<.<<...............>>.>>>>>>>>.....>>..<<<..<<......>>....>>>....<<<<<<.........>>>>>><<<..>>>.................<<<...<.<<<....>>>..>>>>....................... ..((((.(((......))))))).............((.....(((..(((((.((...............)).)))))))).....))..(((..((......))....)))....((((((.........))))))(((..)))...............(.(((...(.(((....)))..)))))...................... Structure of the mitochondrial ribosome from Polytomella magna with tRNAs bound to the A and P sites; mtSSU-2 8apo B3 379 3.2 RF00177,RF01959,RF02542,RF01960 URS0002617754_353565 36253367 0003735 0005840 353565 gagcuccggcuaauugugugccagcagccgcgggaauacacaaggggccaguuuaagguuaaaacaaggcaacgguguuuaaaaacuggaaaugcgccuaaaauagcuuaaugcguuggaguaaggguuaaaucuguaaaaaccuugcagaaagccuuaaaguaaaagcagcuauucaugcccauaaaacagucuauaaacgagagcugcgguagcaaaacggauuagauacccguguagucccagccguaaauuauuuauuaaauuaaagcgccuagcgauauugccuauggcacuaaacuagggaaucugacagcauuaaacugacgcgguggagcauacuucuuaauuugauaauacgcaaaaacauuaccacgau ..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>...................<<<......<<<<<...<<.....<<<.<<.<..<<<<<<<<..<<<...<<....<<<......>>>.......>>..>>>..>>.................>>>>>>.>.>>.>>>......>>...>>>>>....<<<<.<...<<...<<<<.<.....>.>>>>...>>>.>>>>.........<<<<......>>>>..>>>.<<......<<<<...>>>>.....>>.................................................<<........>>................ (.((((([[[...(((((.....((.]]])).......)))))))))))..................(((....(.((((....((.....(((.((.(..((((((((..(((...((....((........)).......))..)))..)).................)))))).).)).)))......))....))))....((((.(...((...((((.........))))...))).)))).........((((......)))).)))).((......((((...)))).....)).................................................((........))................ Structure of the mitochondrial ribosome from Polytomella magna with tRNAs bound to the A and P sites; mtSSU-3 8apo B4 337 3.2 RF00177,RF01960,RF02542,RF01959 URS000261777E_353565 36253367 0003735 0005840 353565 aaaccacgguauugcauggcugauauauaauccauacaaaggauauaaccaaguagcauggucuuauauugugggcuggcggugugcuacaaguaacaaaaaguacaaccggauuaauuacugaaaucauaaauauaaagagggaaucgcuaguaaucuuuauuauaacauaaaggugaaccaguuuagugugcacacacugcccgucacauccgggaaaaccacaaagcccuaaguuuguauaguguuuaauaaaccaauucaaacauaagcuuauuguuaacaaggaugaagucguaacaagguuugcguaggggaaccugcucaagauuaugcu .......<<.<<...<<<<<<.....<<<.<<<.......>>>>>>.....>>>..>>>.>>>>...............................<<.....>>.....<....<<.<<<.........>>>.>>....>...............<<<<<<<<......>>>>>>>>........................<..<<.<.<<<<<..<..<<<.<..<<<<.....<<<<<.<<.<.<<.......>>>.>>.>>>>>....>>>>.>.>>>..>..>>>>>..>.>>...>.....<<<.<<<<<....>>>>>.>>>......... .......((.(((...((((((....(((.(((.......))))))...).)))..)).))))).........................(.....((.....)).....(....((.(((.........))).))....)..)............(((((((((...).))))))))......................(.(..((.(.(((((..(...((.....(((.....(((((.((.(.((.......))).)).)))))....)))....))...)..)))))..).))...)..)..(((.(((((....))))).)))......... Structure of the mitochondrial ribosome from Polytomella magna with tRNAs bound to the A and P sites; mtSSU-4 8apo C1 23 3.2 URS000268142D_353565 36253367 353565 agcacugguuucauaagccagcu ....<<<<<<.....>>>>>>.. ....(((((.......))))).. Structure of the mitochondrial ribosome from Polytomella magna with tRNAs bound to the A and P sites; P-site tRNA anticodon loop 8apo C2 21 3.2 URS000268143F_353565 36253367 353565 gcacugguuucauaagccagc ...<<<<<<.....>>>>>>. ...(((((.......))))). Structure of the mitochondrial ribosome from Polytomella magna with tRNAs bound to the A and P sites; A-site tRNA anticodon loop 8as7 P 17 2.6 URS0002681368_992210 36651274 992210 acacagagacgcccaga .<.....>......... .(.....)......... Structure of the SFTSV L protein stalled at early elongation [EARLY-ELONGATION]; RNA (5'-R(*AP*CP*AP*CP*AP*GP*AP*GP*AP*CP*GP*CP*CP*CP*AP*GP*A)-3') 8as7 T 17 2.6 URS000268137D_992210 36651274 992210 cugggcggucuuugugu ................. ................. Structure of the SFTSV L protein stalled at early elongation [EARLY-ELONGATION]; RNA (5'-R(P*CP*UP*GP*GP*GP*CP*GP*GP*UP*CP*UP*UP*UP*GP*UP*GP*U)-3') 8asb P 17 3.6 URS0002681368_992210 36651274 992210 acacagagacgcccaga ................. .(.....)......... Structure of the SFTSV L protein stalled at early elongation with the endonuclease domain in a raised conformation [EARLY-ELONGATION-ENDO]; RNA (5'-R(*AP*CP*AP*CP*AP*GP*AP*GP*AP*CP*GP*CP*CP*CP*AP*GP*A)-3') 8asb T 18 3.6 URS000268137D_992210 36651274 992210 ucugggcggucuuugugu .................. .................. Structure of the SFTSV L protein stalled at early elongation with the endonuclease domain in a raised conformation [EARLY-ELONGATION-ENDO]; RNA (5'-R(P*UP*CP*UP*GP*GP*GP*CP*GP*GP*UP*CP*UP*UP*UP*GP*UP*GP*U)-3') 8asd T 17 2.6 URS000268137D_992210 36651274 992210 aaagaucugggcugugu ................. ................. Structure of the SFTSV L protein stalled at late elongation [LATE-ELONGATION]; RNA (5'-R(P*AP*AP*AP*AP*AP*AP*GP*AP*UP*CP*UP*GP*GP*GP*CP*GP*GP*UP*CP*UP*UP*UP*GP*UP*GP*U)-3') 8auv h 1626 2.38 RF01960,RF02542,RF01959,RF00177 URS000268141E_4097 37156858 0003735 0005840 4097 uaccugguugauccugccaguagucaunugcuugucunaaagauuaagccaugcauguguaaguaugaacaaauucagacugugaaacugcgaauggcucauuaaaucaguuauaguuuguungaugguaucuacuacunggauaaccguaguaauucuagngcuaauacgugcaacaaaccccgacuucuggaagggaugcauuuauuagauaugcnaugauucaugauaacucgacggaucgcacggccgccggcgacgcaucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguggugacgggugacggagaaunaggguucgauuccggaganggagccugagaaacggcuaccacauncaaggnaggcagcaggcgcgcnaauuacccaauccugacacggggaggunguganaauaaauaacaauaccggcugguaauuggaaugaguacaaucuaaaucccuuaacgaggnuccauuggagggcaagucuggugccagcagccgcggnaauuccagcuccaauancguanauuuaaguugnugcaguunaaaagcucguaguuggacuuugggaugucccguuacuuugaagaaauuagagugcucaaagcaagccuacgcucuguauacauungcaugggauaacauuauaggauuucgguccuauuucgggaucggaguaaugauuaacagggacagucgggggcauncguauuucauagucagaggugaaauucuuggauuuaugaaagacgaacaacugcgaaagcauuugccaaggauguuuucauuaaucaagancgaaaguugggggcucgaagacgaucagauaccgnccuagucucaaccauaaacgaugccgaccagggaucggcggauguugcuaggacuccgccggcaccuuaugagaaaucaaaguuuuuggguuccggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacncaacacggggaaacuuaccagguncagacauaguaagganugacagacugagagcucuuucuugauucuauggguggngnugcauggcnguucuuaguugguggagcgauuugucugguuaauuccguuaacgancgagaccucagccugcuaacuagcuaugcggagguaucccuucgcggccagcuncuuagagggacuacggccuuuuaggccgcggaaguuugaggcaauaacangucugugaugcccnuagauguucugggccgcacgcgcgcuacacugauguauucaacgaguuuauagccuuggccgacaggcccggguaaucuuugaaauuucaucgugauggggauagaucauugcaauuguuggucuucaacgnggaauuccuaguaagcgcgagucaucagcucgcguugacuacgucccugcccuuuguacacaccgnccgucgcuccuaccgauugaaugauccggugaaauguucggaucgcgcgagaaguccauugaaccuuaucauuuagagganggagaagucguancaagguuucnguaggugnnccugcggaaggaucauug ...<<<<<.[.((((>>>>>.<<<.<<<<<<...<.<...<......<<<.<<<..<<....<<....<<...........>>...>>.>>......<<........<<<..<<..<<....<<<<<............<<.....<..<<<.....>>>..>......>>........<.<<<..<<...>>..>>>.>....<<<<<<................>>>>>>.........<<<<.<<<<.>>>>>>>>..>>>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>..>>>..>....>.>.....<<<<<<<<..>>>>>.>>>......<<..<...........>..>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>>>>..........<.<((.....<.<<...<<<.<<.....<<<..>>>.<<<<<<.<<.......<<...<.......>..<<<....>>>.....>>......>>.>>..>>>>........<<<<<<<<<<<.....>>>>>>>>>>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<.<..>>>>>>>>>>>>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<.......<<........>>..........<<<<<......<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<......>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<.<<<<<<<<....>>>>>>>>...>>>>..>>>>.>>.....<<<<<.....>>>>>........>>>>>....>>>.>>>.....>>>>>>>.......>>>>>....>.>>>>.>>>.....<<<<.<.......<<.......<<<.<<<<....>>>>.>>>....>>.......>.>>>>......<....<<<<<<..........>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<<.<<....<<<<<<<..<<<..<<<<..<...<<<<>>>>...>..>>>>..>>>..>>>>>>>...>>.>>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))...(..(((((...(.(....(.....(((.(((..((....((....((...........))...))[))......(((.......(.(...(..((....(((((........[...((.....(..(((.....)))..)......))..........(((..(.....)..)))..(((.((.(((.......(......).))).)).).).).(]((((..(((.))).))))).)))))...)))...).).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(..(....)..)...)))))).).....(.(((....(((.]...)))..))))......).).....((((((((()))))).)))....(.(.(.(...........))..)......)..((((([[....(.((((.....((..]])).......))))))))))..))))).).....[......(.([[...(.(.((...(.(..(....((((..))))(((.((.((........(..((.......)).(((....))).....).......)).))...)))........(((((.((.((.....)).)).))))).....)....(((..((..(...(((...(((.(((((((....((........)).......))))))).))).......((....))....)))..)..))...))..)).)...)).)....((((((....(...((((.........))))...).))))))......{....((.((.(((..((((((((.(((.(..))))))))))))..)))...((..]]))...))...].)).)).).(((......((((....))))....)))...]]].]((((..(((((((..((..(((((..(((..(((((.......(........)...........(((((.(....(((((........((.(((........))).))......)))))...((.(((...(.((((((....((..((((......))..(.((......)))...))..))....(((((.((..((((..((((.((((((((....))))))))...))))..)))).))..(..(((((.....))))).....)..)))))....))).))).....).))))).....).)))))...)).)))..))).(...((((.(.......((.......(((.((((....)))).)))....)).......).))))......(....(((((............)))))....)..)..)))))......(((((((.......))))))).......))...))))))).)).))..(.(..((.(.(((((.((..(.(((((((..(((..((((..(...(((())))...)..))))..)))..))))))))..)).)))))..).))...)..)..(((((((((....)))))))))}........ Cryo-EM structure of the plant 40S subunit; 18S rRNA 8auv B 12 2.38 37156858 4097 uuuuuuuuuuuu ............ ............ Cryo-EM structure of the plant 40S subunit; mRNA 8aye A 1519 1.96 RF00177,RF01959,RF02542,RF01960 URS00000ABFE9_562 36806263 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugccggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<........>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<.>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<..>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((........))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((.)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....(((.((((.......)))).))).....)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((((())))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...((.(((....))).))..............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... E. coli 70S ribosome bound to thermorubin and fMet-tRNA; 16S rRNA 8aye Z 76 1.96 RF00005 URS00002905B5_562 36806263 0030533 0006412 562 gcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... E. coli 70S ribosome bound to thermorubin and fMet-tRNA; P-site tRNA-fMet 8aye a 2753 1.96 RF02541 URS00026813A2_562 36806263 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagcgucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcgcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<..>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<..>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<..<<....>>...>>>>>..>....>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<..>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((((((.....))))).))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{..()....)))..))))).))...........]]].)...))))))))))...)))))))((((((((()))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((())))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).).....((.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..))....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). E. coli 70S ribosome bound to thermorubin and fMet-tRNA; 23S rRNA 8aye b 119 1.96 RF00001 URS0000049E57_562 36806263 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>> ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))) E. coli 70S ribosome bound to thermorubin and fMet-tRNA; 5S rRNA 8azw C 119 2.14 RF00001 URS000071F216_4097 37156858 0003735 0005840 4097 ggaugcgaucauaccagcacuaacgcaccggaucccaucagaacuccgaaguuaagcgugcuugggcgagaguaguacuaggaugggugacccccugggaaguccucguguugcauccc <<<<<<<<<....<<<<<<<......<<<<<..............>>>..>>.....>>>>>.>><<<<<.<.....<<<<<..<<....>>.>>>>>....>.>>>>>>>>>>>>>>. (((((((((....(((((((......((((((...(....)...))))..)).....))))).))(((((.......(((((..((....)).)))))......)))))))))))))). Cryo-EM structure of the plant 60S subunit; 5S rRNA 8azw A 3196 2.14 RF02543 URS0002681419_4097 37156858 0003735 0005840 4097 gcgaccccaggucaggcgggacuacccgcugaguuuaagnauancaanaagcggaggaaaagaaacuuacaaggauuccccuaguaacggcgagcgaaccgggaacagcccagccuuagaaucgggcggcuccgccguucgaanuguagucuggagaagcguccucagcggcggaccgggcccaaguccccuggaagggggcgccagagagggugagagccccguugugcccggacccugucgcaccacgaggcgcugucuacgagucggguuguuugggaaugcagcccaaaucnggcggugaauuccguccaaggcuaaauacgggcgagagaccgauagcgaacaaguaccgcgagggaaagaugnaaaggacuuugaaaagagagucaaagaguncuugaaauugucgggagggaagcggaugggggccggcgaugcgccccggucggauguggaacggugacgagccgguccgccgaucgacucggggcguggaccagcguggauugggggggcggccaaagcccgggcuuucgauacgcccguggaacgccgucuccuugauugugguaggcagcgcgcgccuccggcgugcuucggcaucugcgcgcuccggacgcuggccugugggcuccccauucgacccgucuugnaacncggaccaaggagunngacaugugugcgagucaacgggcgaguaaacccguaaggcguaaggaagcugauuggugggaucccccugaggggugcaccgccgaccgaccuugaucuucugugaaggguncgagugugagcauaccngucgggacccnanagauggugancuaugccugagcggggcgaagccagaggaaacucugguggaggcccgcagcgauacugncgugcaaaucguucgucugacuuggguauagnggcgaaagacuaaucgaaccgucuagungcugguucccuccgaaguuucccucaggauagcuggagcucgcgugcgaguucuaucggguaaagccaaugauuagaggcaucgggggcgcaacgcccucgaccuauucucaaacuuuaaanagguaggacggugcggcugcuuuguugagccgcaccacggaaucaagagcuccaagugggccauuuuugguaagcngaacuggcgaugcgggaugaaccggaagccggguuacggugccaaacugcgcgcuaaccuagaucccacaaaggguguuggucgauuaagacagcgccgaaucaacuagccccgaaaauggauggcgcuuaagcgcgcgaccuacacccggccgucggggcaagugccaggccccgaugnguaggagggcgcggcggucgcugcaaaaccuugggcgcgagccugggcggagcggccgucggugcagaunuuggugguagunncaaauauucaaaugagaanuuugaaggccgaagaggggaaagguuccaugugaacggcacuugcacauggguuagncgauccuaagggucgggggaaccccgacagauagcgcguuucgcgcguacuccgaaagggaaucggguuaaaauuccugaaccgggacguggcgguugacggcaacguuaggaaguccggagacgucggcgggggccucgggaagaguuaucuuuucuguuuaacagccugcccacccuggaaacgacucagucggagguaggguccagcggcuggaagagcaccgcacgucgcgugguguccggugcgcccccggcggcccuugaaaauccggaggaccgagugccguccacgcccggucguacucauaancgnaucangucuncaaggugaacagccucuggucgauggaacaanguaggcaagggaagucggcaaaauggauccguaacuucgggaaaaggauuggcucugagggcugggaacagccaacucagaacugguacggacaagnngnauccgacuguuuaauuaaaacaaagcauugcgauggucccugcggauguuuacgcaaugugauuucugccnagugcucugaaugucaaagugangaaauucaaccaagcncggguaaacggcgggaguancuaugacucucuuaagguagcnaanugccucnucaunuaauuagugacgcgcaugaauggauuancgagnuucccacugunccugucuacnauccagcgaaaccacagncaagggaacgggcuuggcagaaucancggngaaagaagacccunnugagcuugacncuaguccgacuuugugaaaugacuugagaggguaguauaagugggagccggcgaaagugaaauaccacuacuuuuaacguuauuuuacuuauuccgugaaucggaagcggggcacugccccucuuuuuggacccaaggcuugcuugcaggccgauccgggcggaagacauugucagguggggaguuuggcugnggcggcacaucuguuaaaagnuaacgcaggnnuccuaagaugagcucaacgagaacagaaaunucguguggaacagaaggguaaaagcucguuugauncugauuuccagnacgaanacgaaccgugaaagcguggccuaacgauccuuuagaccuucggaauucgaagcuanangugucagnaaaguuaccacagngauaacuggcuuguggcagcnaagcguucauagcgacguugcuuuuugauccuungaugucggnucunccuaucauugugaagcagaauucaccanguguungaunnuucacccaccaauagggaacgugngnugggnuuagancgucgugagacagguuaguuuuacccuacugaugacagugucgcaauaguaauucaaccuaguacgagaggaaccguugauucgcacaauuggucaucgcgcuugguugaaaagccaguggcgcgaagcuaccgugcgcuggauuaugacugaacgccucuaagucagaauccgggcuagaagcgacgcaugcgcccgccguccgcuugccgacccgcaguaggggccuuuggcccccaagggcacgugucguuggcuaagucaucguggcggaagagccgcgguggccgccuugaaguacaauuuccaucgagcggcggguagaanccuuugcagacgacnuaaauacgcgacgggguauuguaaguggcagaguggccuugcugccacgauccacugagauucagcccuuugucgcuccgauucgu ........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<.......<.....>......>>>>>..[[[....<......<<<<<<<<<...>>>>>>>>>......>.....<<<<<<<<.<<<.<<<<<<<.<<<<<<.<<...<<<<......>>>>.((......<<<.....))>>>..>>.>>>>>>...>>>>>>>.....>>>>>>>>.>>>.......<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<<<<<......<<<<<<<<<<<<...<<<<<.<<<<.....>>>>.>>>>>....>>>>.>>>>>>>>.<.<<<<<<..<<<<<<<<<<<<<<<.....<<<<<<<.........>>>>>.>>...>>>>>>>>>>>>>>>.........<<<<<<<<<<...>>>..<<....>>....>>>>>>>.....>>>>>>.>....>>>.>>>>>>>>>..<<<<........>>>><<<<<<.....<<<<<.<<<<<<..<<<...<<<........>>>....>>>...<<....>>....<<<<<...<<<<....>>>>....>>>>>.<<<<<<<.....<....>.....>>.>>>.>>....>>>>>>.>>>>>...<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<......<<.<<<<<<<.....<<<....<<<....<<<....<<<<<<.....>>>>>>..>>>....>>>..>.>>.....>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>..>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.......<..........<<<.<<<<<<.<<<.......<..>...>>>.>>>>>>>>>..........))).>....>>>>>>.>>>...>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<<<<.......<<<.<<<<....>>>>>>>....>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<...>>>>>.....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<<...<<<....>>>...<...<<<<<<...<<<<.<<<<<<<.<<<<<.<<<<.......>>>>.><...<<<<<.....<<<<<<....<<<<...>>>>....>>>>>>.....>>>>>....><<<<<<<.......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>...>......>>>>.>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<....>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<....>>>>......>>>>>>>...<<..<<<..<<<<<<.<..<<<.....<<<<....>>>>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<.<<<...<<<<<<<<<<.<<<<<<.........<<<<.<.<<<>>>............>>>>>.>>>>>>..>>>>>>>>>>...<<<<<.....<<<<...<<<<<...>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>......>>>.>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<<<.<<<<<......>>>>>...>>>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<..<<<<.<.<<<<<.................>>>>>.><<<<<...<<<<....<<<<<<<<<......>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>...>>>>>>>....<<<<<<<<<.<<.<......<<.......<<<<<<...>>>>>>....>>...........<<<...<<<<<<<<<<<......>>>>>>>>>>>.>>>................>.>>.>>>>>>>>>.<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<.<..<<<<<......>>>>>..>>>>>...>>>....>>>>..>>>>>...>>>>>.. ........................(((((......(...[.{).......)))).).........((....))...((((.......(.].}.)......))))...((((.........((((((((((...)))))))))....)........(((((((.(((.(((((((.((((((.(..({((((......)))))[[(...).(((....}]])))...).))))))...))))))).....)))))))).))...)....(((((((........))))))).....((.((..[[[[[[)).))..)))..................................((....))............(..((((....))))............).....................((.(((((((((..(...((((((((((((...(((((.(((.......))).)))))....)))).)))))))).(.(((((((.((.((((((((((((.....(((((((.........))))).))...)))))))))))).)).........((((((((((...)))(.((....))..).)))))))....))))))).)...)))).)))))).)).[((((........))))((((((....((((((.(((.((..(((...(((........)))....)))...((....))....(((((...((((....))))....))))).(((((((.....(....).....)).))).))....)).))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....((..((.(..........))).))...).))))))))).(.((.......))...)..))))))......).))..((((((....(..((....))..)((((((((((......((.(((((.(......((.....(...(.(((....((((((.....))))))..))).)...)...)).......).)))...(((((((((.(......))))))))))....))))..)))))))).))..((((....((.....))....))))....(((......)))...(((((((...((([[[...(.((((((.......(..........(((.((((((.(((.....{........))).)))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((((.......(((.((((....)))))))....))))))))))..).....))))))((.....((.....((((.(.......).))))((((.....((((..((..(((((((...((.....)).))))))....[[(((.((...(((.(((((....)))..).)...(((((...)))))...).))....))...(((((........)))))]]((((.((((((((..((((....)))...(..<((((((...((((.(((((((((((((.(((....{{...))).)(...((((((....(((((.....(((.....))).....)))))...).)))))....)(((((((.......))))))))))).).))))))).))))(...)....))))))...)).....)))).)))))))).))).))).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((....)))))..)))))).))(...).......(((((((((.].(...........)...(((((((....((((....))))......))))))).}.(.(.(((..((((((.(...(......((((....))))......).)))))..)))))(.(.(.........).).)........((..........(((((.......)))))..)..)....).)....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.(((((...(((((.(((.(((...((((((((((...((((..[......(((....((())).......]......))).))))....))))))))))...(((((.....((((.(.((((.....)))).).........>...((((((....))))))..))))..)))))......))).)))..)))))..(((......[)).)..((((..........]))))..([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(.(((..((((....{..))))..))))((......)).))]]].......((((((..((((.]]]]]]))))))))))....)}.....)))..)))))).......(....(.((((.(...((.......))...).))))...)....)........((((.((((((..(((.(.(((......))).)...))).(((.(.....).))).....)))))..)...))).)......((((((....))).))).....))..))).)))))....(((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))...)))))))....(((((((((.((.(....(.((.......((((((...))))))....)))..........(((...(((((((((((......))))))))))).)))................).)).))))))))).(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....))))..))))))..))))).. Cryo-EM structure of the plant 60S subunit; 25S rRNA 8azw B 163 2.14 RF00002 URS000268141B_4097 37156858 0003735 0005840 4097 aaacgacucucggcaacggauaucucggcucucgcaucgaugaagnacguagcgaaaugcgauacuuggugugaauuncagaauuccgugaaccaucgagucuuugaacgcaaguugcgcccgaagccauuaggccgagggcacgucugccugggcgucacgc ............................................<<<<<<.((.....>>>....<<<<<<<.....))............>.>>>>.>>..>>>....<<.....>><<<<...<<......>>...>>>>..................... ............................................((((((.[[.....))).....((.(((.....]]............).)).).)...)))....((.....))((((...(.(.....))...))))..................... Cryo-EM structure of the plant 60S subunit; 5.8S rRNA 8b0x A 1500 1.55 RF00177,RF01959,RF02542,RF01960 URS00019B7399_37762 36841832 0003735 0005840 37762 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaauucgcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugccggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugcgaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauc .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<..>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<.>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<..>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>.......>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((())).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((.)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(..(.((((((((.......)))))))).)...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((((())))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))...()..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Translating 70S ribosome in the unrotated state (P and E, tRNAs); 16S rRNA 8b0x Z 75 1.55 RF00005 URS0002617796_37762 36841832 0030533 0006412 37762 gcgggguggagcagccugguagcucgucgggcuuacaacccgaaggcgucgguucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......)))))....(((((..]....)))))))))))..... Translating 70S ribosome in the unrotated state (P and E, tRNAs); P-site tRNA 8b0x a 2748 1.55 RF02541 URS00026177A6_37762 36841832 0003735 0005840 37762 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacagcugugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagcgucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcgcguuguuggguaggggagcguucuguaagccugugaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcggcgcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauauguucuaacguuggccccugaucgggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacuccuugagaguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<..>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<..>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<..>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<..<<<.>>>...>>>>>..>....>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<..>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((())))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((((((.....))))).))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(())...)))..))))).))...........]]].)...))))))))))...)))))))((((((((()))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..(((.)))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((())))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).).....((.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..))....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Translating 70S ribosome in the unrotated state (P and E, tRNAs); 23S rRNA 8b0x b 119 1.55 RF00001 URS000080E133_37762 36841832 0003735 0005840 37762 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>> ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))) Translating 70S ribosome in the unrotated state (P and E, tRNAs); 5S rRNA 8b2l h1 1626 2.2 RF01960,RF02542,RF01959,RF00177 URS000268141E_4097 37156858 0003735 0005840 4097 uaccugguugauccugccaguagucaunugcuugucunaaagauuaagccaugcauguguaaguaugaacaaauucagacugugaaacugcgaauggcucauuaaaucaguuauaguuuguungaugguaucuacuacunggauaaccguaguaauucuagngcuaauacgugcaacaaaccccgacuucuggaagggaugcauuuauuagauaugcnaugauucaugauaacucgacggaucgcacggccgccggcgacgcaucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguggugacgggugacggagaaunaggguucgauuccggaganggagccugagaaacggcuaccacauncaaggnaggcagcaggcgcgcnaauuacccaauccugacacggggaggunguganaauaaauaacaauaccggcugguaauuggaaugaguacaaucuaaaucccuuaacgaggnuccauuggagggcaagucuggugccagcagccgcggnaauuccagcuccaauancguanauuuaaguugnugcaguunaaaagcucguaguuggacuuugggaugucccguuacuuugaagaaauuagagugcucaaagcaagccuacgcucuguauacauungcaugggauaacauuauaggauuucgguccuauuucgggaucggaguaaugauuaacagggacagucgggggcauncguauuucauagucagaggugaaauucuuggauuuaugaaagacgaacaacugcgaaagcauuugccaaggauguuuucauuaaucaagancgaaaguugggggcucgaagacgaucagauaccgnccuagucucaaccauaaacgaugccgaccagggaucggcggauguugcuaggacuccgccggcaccuuaugagaaaucaaaguuuuuggguuccggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacncaacacggggaaacuuaccagguncagacauaguaagganugacagacugagagcucuuucuugauucuauggguggngnugcauggcnguucuuaguugguggagcgauuugucugguuaauuccguuaacgancgagaccucagccugcuaacuagcuaugcggagguaucccuucgcggccagcuncuuagagggacuacggccuuuuaggccgcggaaguuugaggcaauaacangucugugaugcccnuagauguucugggccgcacgcgcgcuacacugauguauucaacgaguuuauagccuuggccgacaggcccggguaaucuuugaaauuucaucgugauggggauagaucauugcaauuguuggucuucaacgnggaauuccuaguaagcgcgagucaucagcucgcguugacuacgucccugcccuuuguacacaccgnccgucgcuccuaccgauugaaugauccggugaaauguucggaucgcgcgagaaguccauugaaccuuaucauuuagagganggagaagucguancaagguuucnguaggugnnccugcggaaggaucauug ...<<<<<.[.((((>>>>>.<<<.<<<<<<...<.<...<......<<<.<<<..<<....<<....<<...........>>...>>.>>......<<........<<<..<<..<<....<<<<<............<<.....<..<<<.....>>>..>......>>........<.<<<..<<...>>..>>>.>..<.<<<<<<................>>>>>>.>.......<<<<.<<<<.>>>>>>>>..>>>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>..>>>..>....>.>.....<<<<<<<<..>>>>>.>>>......<<..<...........>..>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>>>>..........<.<((.....<.<<...<<<.<<.....<<<..>>>.<<<<<<.<<.......<<...<.......>..<<<....>>>.....>>......>>.>>..>>>>........<<<<<<<<<<<.....>>>>>>>>>>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<.<..>>>>>>>>>>>>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<.......<<........>>..........<<<<<......<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<......>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<.<<<<<<<<....>>>>>>>>...>>>>..>>>>.>>.....<<<<<.....>>>>>........>>>>>....>>>.>>>.....>>>>>>>.......>>>>>....>.>>>>.>>>.....<<<<.<.......<<.......<<<.<<<<....>>>>.>>>....>>.......>.>>>>......<....<<<<<<..........>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<<.<<....<<<<<<<..<<<..<<<<..<...<<<<>>>>...>..>>>>..>>>..>>>>>>>...>>.>>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))...(..(((((...(.(....(.....(((.(((..((....((....((...........))...))[))......(((.......(.(...(..((....(((((........[...((.....(..(((.....)))..)......))..........(((..(.....)..)))..(((.((.(((.......(......).))).)).).).).(]((((..(((.))).))))).)))))...)))...).).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(..(....)..)...)))))).).....(.(((....(((.]...)))..))))......).).....((((((((()))))).)))....(.(.(.(...........))..)......)..((((([[....(.((((.....((..]])).......))))))))))..))))).).....[......(.([[...(.(.((...(.(..(....((((..))))(((.((.((........(..((.......)).(((....))).....).......)).))...)))........(((((.((.((.....)).)).))))).....)....(((..((.((...(((...(((.(((((((....((........)).......))))))).))).......((....))....)))..)).))...))..)).)...)).)....((((((....(...((((.........))))...).))))))......{....((.((.(((..((((((((.(((.(..))))))))))))..)))...((..]]))...))...].)).)).).(((......((((....))))....)))...]]].]((((..(((((((..((..(((((..(((..(((((.......(........)...........(((((.(....(((((........((.(((........))).))......)))))...((.(((...(.((((((....((..((((......))..(.((......)))...))..))....(((((.((..((((..((((.((((((((....))))))))...))))..)))).))..(..(((((.....))))).....)..)))))....))).))).....).))))).....).)))))...)).)))..))).(...((((.(.......((.......(((.((((....)))).)))....)).......).))))......(....(((((............)))))....)..)..)))))......(((((((.......))))))).......))...))))))).)).))..(.(..((.(.(((((.((..(.(((((((..(((..((((..(...(((())))...)..))))..)))..))))))))..)).)))))..).))...)..)..(((((((((....)))))))))}........ Cryo-EM structure of the plant 80S ribosome; 18S rRNA 8b2l B1 12 2.2 37156858 4097 uuuuuuuuuuuu ............ ............ Cryo-EM structure of the plant 80S ribosome; mRNA 8b2l i2 76 2.2 RF00005 URS00001504D0_4097 37156858 0030533 0006412 4097 gcggggauagcucaguugggagagcgucagacugaagaucugaaggucgcguguucgauccacgcucaccgcacca <<<<.<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>.>>>>.... ((((.((..((((.....[..)))).(((((.......))))).....(((((..]....))))))).)))).... Cryo-EM structure of the plant 80S ribosome; tRNA 8b2l W2 76 2.2 RF00005 URS00001504D0_4097 37156858 0030533 0006412 4097 gcggggauagcucaguugggagagcgucagacugaagaucugaaggucgcguguucgauccacgcucaccgcacca <<<<.<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>.>>>>.... ((((.((..((((.....[..)))).(((((.......))))).....(((((..]....))))))).)))).... Cryo-EM structure of the plant 80S ribosome; tRNA 8b2l C3 119 2.2 RF00001 URS000071F216_4097 37156858 0003735 0005840 4097 ggaugcgaucauaccagcacuaacgcaccggaucccaucagaacuccgaaguuaagcgugcuugggcgagaguaguacuaggaugggugacccccugggaaguccucguguugcauccc <<<<<<<<<....<<<<<<<......<<<<<..............>>>..>>.....>>>>>.>><<<<<.<.....<<<<<..<<....>>.>>>>>....>.>>>>>>>>>>>>>>. (((((((((....(((((((......((((((...(....)...))))..)).....))))).))(((((.......(((((..((....)).)))))......)))))))))))))). Cryo-EM structure of the plant 80S ribosome; 5S rRNA 8b2l A3 3196 2.2 RF02543 URS0002681419_4097 37156858 0003735 0005840 4097 gcgaccccaggucaggcgggacuacccgcugaguuuaagnauancaanaagcggaggaaaagaaacuuacaaggauuccccuaguaacggcgagcgaaccgggaacagcccagccuuagaaucgggcggcuccgccguucgaanuguagucuggagaagcguccucagcggcggaccgggcccaaguccccuggaagggggcgccagagagggugagagccccguugugcccggacccugucgcaccacgaggcgcugucuacgagucggguuguuugggaaugcagcccaaaucnggcggugaauuccguccaaggcuaaauacgggcgagagaccgauagcgaacaaguaccgcgagggaaagaugnaaaggacuuugaaaagagagucaaagaguncuugaaauugucgggagggaagcggaugggggccggcgaugcgccccggucggauguggaacggugacgagccgguccgccgaucgacucggggcguggaccagcguggauugggggggcggccaaagcccgggcuuucgauacgcccguggaacgccgucuccuugauugugguaggcagcgcgcgccuccggcgugcuucggcaucugcgcgcuccggacgcuggccugugggcuccccauucgacccgucuugnaacncggaccaaggagunngacaugugugcgagucaacgggcgaguaaacccguaaggcguaaggaagcugauuggugggaucccccugaggggugcaccgccgaccgaccuugaucuucugugaaggguncgagugugagcauaccngucgggacccnanagauggugancuaugccugagcggggcgaagccagaggaaacucugguggaggcccgcagcgauacugncgugcaaaucguucgucugacuuggguauagnggcgaaagacuaaucgaaccgucuagungcugguucccuccgaaguuucccucaggauagcuggagcucgcgugcgaguucuaucggguaaagccaaugauuagaggcaucgggggcgcaacgcccucgaccuauucucaaacuuuaaanagguaggacggugcggcugcuuuguugagccgcaccacggaaucaagagcuccaagugggccauuuuugguaagcngaacuggcgaugcgggaugaaccggaagccggguuacggugccaaacugcgcgcuaaccuagaucccacaaaggguguuggucgauuaagacagcgccgaaucaacuagccccgaaaauggauggcgcuuaagcgcgcgaccuacacccggccgucggggcaagugccaggccccgaugnguaggagggcgcggcggucgcugcaaaaccuugggcgcgagccugggcggagcggccgucggugcagaunuuggugguagunncaaauauucaaaugagaanuuugaaggccgaagaggggaaagguuccaugugaacggcacuugcacauggguuagncgauccuaagggucgggggaaccccgacagauagcgcguuucgcgcguacuccgaaagggaaucggguuaaaauuccugaaccgggacguggcgguugacggcaacguuaggaaguccggagacgucggcgggggccucgggaagaguuaucuuuucuguuuaacagccugcccacccuggaaacgacucagucggagguaggguccagcggcuggaagagcaccgcacgucgcgugguguccggugcgcccccggcggcccuugaaaauccggaggaccgagugccguccacgcccggucguacucauaancgnaucangucuncaaggugaacagccucuggucgauggaacaanguaggcaagggaagucggcaaaauggauccguaacuucgggaaaaggauuggcucugagggcugggaacagccaacucagaacugguacggacaagnngnauccgacuguuuaauuaaaacaaagcauugcgauggucccugcggauguuuacgcaaugugauuucugccnagugcucugaaugucaaagugangaaauucaaccaagcncggguaaacggcgggaguancuaugacucucuuaagguagcnaanugccucnucaunuaauuagugacgcgcaugaauggauuancgagnuucccacugunccugucuacnauccagcgaaaccacagncaagggaacgggcuuggcagaaucancggngaaagaagacccunnugagcuugacncuaguccgacuuugugaaaugacuugagaggguaguauaagugggagccggcgaaagugaaauaccacuacuuuuaacguuauuuuacuuauuccgugaaucggaagcggggcacugccccucuuuuuggacccaaggcuugcuugcaggccgauccgggcggaagacauugucagguggggaguuuggcugnggcggcacaucuguuaaaagnuaacgcaggnnuccuaagaugagcucaacgagaacagaaaunucguguggaacagaaggguaaaagcucguuugauncugauuuccagnacgaanacgaaccgugaaagcguggccuaacgauccuuuagaccuucggaauucgaagcuanangugucagnaaaguuaccacagngauaacuggcuuguggcagcnaagcguucauagcgacguugcuuuuugauccuungaugucggnucunccuaucauugugaagcagaauucaccanguguungaunnuucacccaccaauagggaacgugngnugggnuuagancgucgugagacagguuaguuuuacccuacugaugacagugucgcaauaguaauucaaccuaguacgagaggaaccguugauucgcacaauuggucaucgcgcuugguugaaaagccaguggcgcgaagcuaccgugcgcuggauuaugacugaacgccucuaagucagaauccgggcuagaagcgacgcaugcgcccgccguccgcuugccgacccgcaguaggggccuuuggcccccaagggcacgugucguuggcuaagucaucguggcggaagagccgcgguggccgccuugaaguacaauuuccaucgagcggcggguagaanccuuugcagacgacnuaaauacgcgacgggguauuguaaguggcagaguggccuugcugccacgauccacugagauucagcccuuugucgcuccgauucgu ........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<.......<.....>......>>>>>..[[[....<......<<<<<<<<<...>>>>>>>>>......>.....<<<<<<<<.<<<.<<<<<<<.<<<<<<.<<...<<<<......>>>>.((......<<<.....))>>>..>>.>>>>>>...>>>>>>>.....>>>>>>>>.>>>.......<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<<<<<......<<<<<<<<<<<<...<<<<<.<<<<.....>>>>.>>>>>....>>>>.>>>>>>>>.<.<<<<<<..<<<<<<<<<<<<<<<.....<<<<<<<.........>>>>>.>>...>>>>>>>>>>>>>>>.........<<<<<<<<<<...>>>..<<....>>....>>>>>>>.....>>>>>>.>....>>>.>>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<........>>>....>>>...<<....>>....<<<<<...<<<<....>>>>....>>>>>.<<<<<<<.....<....>.....>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<......<<.<<<<<<<.....<<<....<<<....<<<....<<<<<<.....>>>>>>..>>>....>>>..>.>>.....>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>..>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.......<..........<<<.<<<<<<.<<<.......<..>...>>>.>>>>>>>>>..........))).>....>>>>>>.>>>...>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<<<<.......<<<.<<<<....>>>>>>>....>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<...>>>>>.....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<<...<<<....>>>...<...<<<<<<...<<<<.<<<<<<<.<<<<<.<<<<.......>>>>.><...<<<<<.....<<<<<<....<<<<...>>>>....>>>>>>.....>>>>>....><<<<<<<.......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>...>......>>>>.>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<....>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<....>>>>......>>>>>>>...<<..<<<..<<<<<<.<..<<<.....<<<<....>>>>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<.<<<...<<<<<<<<<<.<<<<<<.........<<<<.<.<<<>>>............>>>>>.>>>>>>..>>>>>>>>>>...<<<<<.....<<<<...<<<<<...>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>......>>>.>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<<<.<<<<<......>>>>>...>>>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<..<<<<.<.<<<<<.................>>>>>.><<<<<...<<<<....<<<<<<<<<......>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>...>>>>>>>....<<<<<<<<<.<<.<......<<.......<<<<<<...>>>>>>....>>...........<<<...<<<<<<<<<<<......>>>>>>>>>>>.>>>................>.>>.>>>>>>>>>.<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<.<..<<<<<......>>>>>..>>>>>...>>>....>>>>..>>>>>...>>>>>.. ........................(((((......(...[.{).......)))).).........((....))...((((.......(.].}.)......))))...((((.........((((((((((...)))))))))....)........(((((((.(((.(((((((.((((((.(..({((((......)))))[[(...).(((....}]])))...).))))))...))))))).....)))))))).))...)....(((((((........))))))).....((.((..[[[[[[)).))..)))..................................((....))............(..((((....))))............).....................((.(((((((((..(...((((((((((((...(((((.(((.......))).)))))....)))).)))))))).(.(((((((.((.((((((((((((.....(((((((.........))))).))...)))))))))))).)).........((((((((((...)))(.((....))..).)))))))....))))))).)...)))).)))))).)).[((((........))))((((((....((((((.(((.((..(((...(((........)))....)))...((....))....(((((...((((....))))....))))).(((((((.....(....).....)).))).))....)).))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))....((..((.(..........))).))...).))))))))).(.((.......))...)..))))))......).))..((((((....(..((....))..)((((((((((......((.(((((.(......((.....(...(.(((....((((((.....))))))..))).)...)...)).......).)))...(((((((((.(......))))))))))....))))..)))))))).))..((((....((.....))....))))....(((......)))...(((((((...((([[[...(.((((((.......(..........(((.((((((.(((.....{........))).)))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((((.......(((.((((....)))))))....))))))))))..).....))))))((.....((.....((((.(.......).))))((((.....((((..((..(((((((...((.....)).))))))....[[(((.((...(((.(((((....)))..).)...(((((...)))))...).))....))...(((((........)))))]]((((.((((((((..((((....)))...(..<((((((...((((.(((((((((((((.(((....{{...))).)(...((((((....(((((.....(((.....))).....)))))...).)))))....)(((((((.......))))))))))).).))))))).))))(...)....))))))...)).....)))).)))))))).))).))).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((....)))))..)))))).))(...).......(((((((((.].(...........)...(((((((....((((....))))......))))))).}.(.(.(((..((((((.(...(......((((....))))......).)))))..)))))(.(.(.........).).)........((..........(((((.......)))))..)..)....).)....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.(((((...(((((.(((.(((...((((((((((...((((.........(((....((()))..............))).))))....))))))))))...(((((.....((((.(.((((.....)))).).........>...((((((....))))))..))))..)))))......))).)))..)))))..(((......[)).)..((((..........]))))..([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(.(((..((((....{..))))..))))((......)).))]]].......((((((..((((.]]]]]]))))))))))....)}.....)))..)))))).......(....(.((((.(...((.......))...).))))...)....)........((((.((((((..(((.(.(((......))).)...))).(((.(.....).))).....)))))..)...))).)......((((((....))).))).....))..))).)))))....(((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))...)))))))....(((((((((.((.(....(.((.......((((((...))))))....)))..........(((...(((((((((((......))))))))))).)))................).)).))))))))).(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....))))..))))))..))))).. Cryo-EM structure of the plant 80S ribosome; 25S rRNA 8b2l B3 163 2.2 RF00002 URS000268141B_4097 37156858 0003735 0005840 4097 aaacgacucucggcaacggauaucucggcucucgcaucgaugaagnacguagcgaaaugcgauacuuggugugaauuncagaauuccgugaaccaucgagucuuugaacgcaaguugcgcccgaagccauuaggccgagggcacgucugccugggcgucacgc ............................................<<<<<<.((.....>>>.....<<<<<<.....))............>.>>>>.>...>>>....<<.....>><<<<...<<......>>...>>>>..................... ............................................((((((.[[.....))).....((.(((.....]]............).)).).)...)))....((.....))((((...(.(.....))...))))..................... Cryo-EM structure of the plant 80S ribosome; 5.8S rRNA 8b5l 5 3619 2.86 RF02543 URS000268139C_9986 36867692 0003735 0005840 9986 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggaaauguggcguacggaagacccacuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagngagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggccggccgugccggcggucucggcggaucuuucccgcucccgggggcgggggaccgccccccggccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcccggggggacgccucgccggcgggcgcgaccccuccccggguguuacagccccgccccggcagcagcagcucgccgaaucccggggccgagggagcgagaccugugucgccgcgcucuccccccugggggggccgggccaccccucccacggcgcgaccgcuggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccgggggccacggcgcgucgcggcgcgcgcgagcgagcgcacggggucggcggcgaugucggcuacccacccgacccnucuugnaacncggaccaaggagucuaacacgngcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgucgccggccgaggugggaucccgaggccuuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccnanagauggugancuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcgaaucgnucguccgaccuggguauagnggcgaaagacuaaucgaaccaucuaguagcuggnucccuccaaaguuucccucaggauagcuggcgcucucgcccgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaaungguaagaagcccggcucgcugguguggagccgggcguggaaugcgagugccuagugggccacnuuugguaagcngaacuggcgcugcgggaugaaccgaacgccggguuaangcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggaugguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgcuggcagucggcagagcgagaaagagaguggcgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguannaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagnanuugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucagccgaucgaaagggagucgnguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcnccgggccguacccauauccgcagcaggucuncaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagcnggauccguaacuucgggauaaggauuggcucuaagggcuggcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugccnagugcucugaaugucanagugnagaaauucaaugaagcgcggguaaacggcgggaguaacnaugacucucuuaagguagcnaaaugccucnucaucuaauuagugacgcgcaugaauggaugancgagauucccacugucccuaccuacuauccagcgaaaccacagncaagggaacgngcuuggnggaaucagcngngaaagaagacccuguugagcuugacucuagucuggcacggugaagagacaugagaacuccgaucguuuuuucacugacccggugaggcgggggggcgagccgggcucucgcuucuggcgccaagcgcccggccccggggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucungauuuucagnacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuungguuuuaagcaggangugucagaaaaguuaccacagggauaacuggcuuguggcggccangcguucauagcgacgucgcuuuuugauccuungaugucggcucuuccuaucauugugaagcagaauucaccaagcguungauuguucacccacuaauagggaacgugngcugggnuuagancgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguncanacauuugguguaunugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacunaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgaggagccucgguuggccucggauagccggucccccgcgggguccggugcggagagcccuucgucccgggaaacggggcgcggccggaaagggggccgcccucucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcugcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..[[[..<<<<<...<<<<<<<<<<<...>>>>>>>.>>>>.....>>>>>..<<<<<<<<<....<<<<<<<<.<<<....<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>>>>>>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<......>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<<<<<<<<<<.<<<<<.<<....<<<<<.<<<..<<<<<<<<..>>>>>>>>>>>>>>>>>>>>>>>>>>>...>>>>>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<<<<<<<<<<<<.<<<<...<<..<<<.<<<<<<<......<<<<<<<<<<.......<....>...........>>>>>>>>>>.......>>>>>>>..>>>.........>>>>>>...>>>>>>>>>>.....<<.....[[>>......<<<<<<.<<<<<<..>>>>>>.<<<<<<..<<<.<<<<<<<<<<<<<<<<<<<<<<<.<<<<....>>>>.>>>>>>.>>>.>>>>>>>>>>>.>>>...>>>>>>>.>><<<<<........>>>>>....>>>>>>.....>>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<.......>>>>>..<<<<<...<<<..<<<....{{.{{.>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<......<<<.<<<<<<<<<...<<<....<<<..<.<<<..<<<<.<.........>.>>>>>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<.......]]...........}}.}}.............>>>>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<<<<<...>>>>>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<..<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<<<<<<<<<<<<..{{{..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>.>.>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<.>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<<.<<<<<<<<<<....<.....>....>>>>>>>>>>...<<<<<.....<<<<..<<.<.<<<>>.>>.>>..............<<<<<<<<<<<..>>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>>.<<<....>>>.>>)))]......((((((..(((..>>>>>>.)))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]].....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<}}}.>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.....<<<<<<<.<<..<<<<....<<<........<<<<<..<<<<..>>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<........>>>>>>>>>>...>>>>..>>>..............>>>>..>>>>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<.<..<<<<<.>>>>>..>>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..(((((((((((.....)))))).))))....))))....(((((((((....((((((((.(((....((((((((..({((((......)))))....[[(...).(((....}]])))...).))))))))))))))))))...)))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....((((((((((((((((((.(((((.((....(((((.(((..(((((.(.().).))))))))))))))))))))))))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((.((..(((......((((((((((........................)))))))))).......)))..))..))).........))))))..))))))))))).....((.....{{))......((((((.((((((..)))))).((((((..(((.((((((((((((((((.((((((.((((....)))).))))))..)).))))))))))).)))...))))))).))((((..........))))..[.)))))).....))).)))))...)))))...)))))))).<((((........))))((((((....(((((((((((((..(((..(((((........))))..)..)))...((....))...((((((.....))))))..(((((...(((..(((]..[[[.[[[)))..)))....))))).(((((((((.((((......))))))))))).))....)))))))))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((......(((.((((((((....(((....(((..(.(((..(((.(..(.....)..).)))))).)..)))..)).)....))))))...(((((((((.(......))))))))))....))))))))))))..))..((((..((((.....))))..))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.......(((((..((...((.........))...))......(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((.......}}.........].]].]]]............)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...(...(.(((....))).....)....((.((((.((((...)))).)))))).......)....))...(((((........)))))]]((((....(((((...((.((((....)))).))..((((....)))...(...((((((...(((((((((((((((((((((((...{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((.)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(...(......(((......)))......).)))))..)))))(.(((.........))).)........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.(((((((((.(((((((((((...(.....)..).))))))))))...(((((.....((((..(..(..(())..)..)..............(((((((((((())))))))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(..((..((((....{..))))..)).)(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......(....(.((((((...((.......))...))))))...)....)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a.))..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}..)))))..)).))...))))...)))).((((...((((.............))))...))))..)))...).)))))).....((((((..((..((((....(((........(((((.(.(((())))).))))).......)))...(((..((((....(.((.(.((((........)))).))).)...))))..)))..............))))..)).))))))(((((.(..(.......)..)....((.(((((((.((.....((((.(..(((((.)))))..)))))....))....)))).))).))..))))).. Cryo-EM structure of ribosome-Sec61-TRAP (TRanslocon Associated Protein) translocon complex; 28S rRNA 8b5l 8 151 2.86 RF00002,RF02540 URS00004B2C76_9986 36867692 0003735 0005840 9986 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcagguugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<<<<....>>>>.....<.<<<......>>........>>>..>...>>>....<<<..>>><<<<<<<<.......>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]]........)))..)...)))....((....))((((((((.......)))))))).................... Cryo-EM structure of ribosome-Sec61-TRAP (TRanslocon Associated Protein) translocon complex; 5.8S rRNA 8b5l 7 120 2.86 RF00001 URS000002B0D5_9986 36867692 0003735 0005840 9986 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. Cryo-EM structure of ribosome-Sec61-TRAP (TRanslocon Associated Protein) translocon complex; 5S rRNA 8b6c 5 3619 2.79 RF02543 URS000268139C_9986 36867692 0003735 0005840 9986 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggaaauguggcguacggaagacccacuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagngagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggccggccgugccggcggucucggcggaucuuucccgcucccgggggcgggggaccgccccccggccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcccggggggacgccucgccggcgggcgcgaccccuccccggguguuacagccccgccccggcagcagcagcucgccgaaucccggggccgagggagcgagaccugugucgccgcgcucuccccccugggggggccgggccaccccucccacggcgcgaccgcuggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccgggggccacggcgcgucgcggcgcgcgcgagcgagcgcacggggucggcggcgaugucggcuacccacccgacccnucuugnaacncggaccaaggagucuaacacgngcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgucgccggccgaggugggaucccgaggccuuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccnanagauggugancuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcgaaucgnucguccgaccuggguauagnggcgaaagacuaaucgaaccaucuaguagcuggnucccuccaaaguuucccucaggauagcuggcgcucucgcccgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaaungguaagaagcccggcucgcugguguggagccgggcguggaaugcgagugccuagugggccacnuuugguaagcngaacuggcgcugcgggaugaaccgaacgccggguuaangcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggaugguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgcuggcagucggcagagcgagaaagagaguggcgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguannaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagnanuugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucagccgaucgaaagggagucgnguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcnccgggccguacccauauccgcagcaggucuncaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagcnggauccguaacuucgggauaaggauuggcucuaagggcuggcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugccnagugcucugaaugucanagugnagaaauucaaugaagcgcggguaaacggcgggaguaacnaugacucucuuaagguagcnaaaugccucnucaucuaauuagugacgcgcaugaauggaugancgagauucccacugucccuaccuacuauccagcgaaaccacagncaagggaacgngcuuggnggaaucagcngngaaagaagacccuguugagcuugacucuagucuggcacggugaagagacaugagaacuccgaucguuuuuucacugacccggugaggcgggggggcgagccgggcucucgcuucuggcgccaagcgcccggccccggggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucungauuuucagnacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuungguuuuaagcaggangugucagaaaaguuaccacagggauaacuggcuuguggcggccangcguucauagcgacgucgcuuuuugauccuungaugucggcucuuccuaucauugugaagcagaauucaccaagcguungauuguucacccacuaauagggaacgugngcugggnuuagancgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguncanacauuugguguaunugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacunaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgaggagccucgguuggccucggauagccggucccccgcgggguccggugcggagagcccuucgucccgggaaacggggcgcggccggaaagggggccgcccucucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcugcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..[[[..<<<<<...<<<<<<<<<<<...>>>>>>>.>>>>.....>>>>>..<<<<<<<<<....<<<<<<<<.<<<....<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>>>>>>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<......>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<<<<<<<<<<.<<<<<.<<....<<<<<.<<<..<<<<<<<<..>>>>>>>>>>>>>>>>>>>>>>>>>>>...>>>>>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<<<<<<<<<<<<.<<<<...<<..<<<.<<<<<<<......<<<<<<<<<<.......<....>...........>>>>>>>>>>.......>>>>>>>..>>>.........>>>>>>...>>>>>>>>>>.....<<.....[[>>......<<<<<<.<<<<<<..>>>>>>.<<<<<<..<<<.<<<<<<<<<<<<<<<<<<<<<<<.<<<<....>>>>.>>>>>>.>>>.>>>>>>>>>>>.>>>...>>>>>>>.>><<<<<........>>>>>....>>>>>>.....>>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<.......>>>>>..<<<<<...<<<..<<<....{{.{{.>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<......<<<.<<<<<<<<<...<<<....<<<..<.<<<..<<<<.<.........>.>>>>>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<.......]]...........}}.}}.............>>>>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<<<<<...>>>>>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<..<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<<<<<<<<<<<<..{{{..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>.>.>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<.>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<<.<<<<<<<<<<....<.....>....>>>>>>>>>>...<<<<<.....<<<<..<<.<.<<<>>.>>.>>..............<<<<<<<<<<<..>>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>>.<<<....>>>.>>)))]......((((((..(((..>>>>>>.)))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]].....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<}}}.>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.....<<<<<<<.<<..<<<<....<<<........<<<<<..<<<<..>>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<........>>>>>>>>>>...>>>>..>>>..............>>>>..>>>>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<.<..<<<<<.>>>>>..>>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..(((((((((((.....)))))).))))....))))....(((((((((....((((((((.(((....((((((((..({((((......)))))....[[(...).(((....}]])))...).))))))))))))))))))...)))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....((((((((((((((((((.(((((.((....(((((.(((..(((((.(.().).))))))))))))))))))))))))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((.((..(((......((((((((((........................)))))))))).......)))..))..))).........))))))..))))))))))).....((.....{{))......((((((.((((((..)))))).((((((..(((.((((((((((((((((.((((((.((((....)))).))))))..)).))))))))))).)))...))))))).))((((..........))))..[.)))))).....))).)))))...)))))...)))))))).<((((........))))((((((....(((((((((((((..(((..(((((........))))..)..)))...((....))...((((((.....))))))..(((((...(((..(((]..[[[.[[[)))..)))....))))).(((((((((.((((......))))))))))).))....)))))))))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((......(((.((((((((....(((....(((..(.(((..(((.(..(.....)..).)))))).)..)))..)).)....))))))...(((((((((.(......))))))))))....))))))))))))..))..((((..((((.....))))..))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.......(((((..((...((.........))...))......(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((.......}}.........].]].]]]............)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...(...(.(((....))).....)....((.((((.((((...)))).)))))).......)....))...(((((........)))))]]((((....(((((...((.((((....)))).))..((((....)))...(...((((((...(((((((((((((((((((((((...{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((.)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(...(......(((......)))......).)))))..)))))(.(((.........))).)........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.(((((((((.(((((((((((...(.....)..).))))))))))...(((((.....((((..(..(..(())..)..)..............(((((((((((())))))))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(..((..((((....{..))))..)).)(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......(....(.((((((...((.......))...))))))...)....)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a.))..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}..)))))..)).))...))))...)))).((((...((((.............))))...))))..)))...).)))))).....((((((..((..((((....(((........(((((.(.(((())))).))))).......)))...(((..((((....(.((.(.((((........)))).))).)...))))..)))..............))))..)).))))))(((((.(..(.......)..)....((.(((((((.((.....((((.(..(((((.)))))..)))))....))....)))).))).))..))))).. Cryo-EM structure of ribosome-Sec61 in complex with cyclotriazadisulfonamide derivative CK147; 28S rRNA 8b6c 8 151 2.79 RF00002,RF02540 URS00004B2C76_9986 36867692 0003735 0005840 9986 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcagguugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<<<<....>>>>.....<.<<<......>>........>>>..>...>>>....<<<..>>><<<<<<<<.......>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]]........)))..)...)))....((....))((((((((.......)))))))).................... Cryo-EM structure of ribosome-Sec61 in complex with cyclotriazadisulfonamide derivative CK147; 5.8S rRNA 8b6c 7 120 2.79 RF00001 URS000002B0D5_9986 36867692 0003735 0005840 9986 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. Cryo-EM structure of ribosome-Sec61 in complex with cyclotriazadisulfonamide derivative CK147; 5S rRNA 8b7y I 2898 3.0 RF02541 URS00004B0F34_83333 36603206 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccuu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<...>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>.>......>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<..<<<............<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>...>>>..>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>.(<<...<<<<<<<...<<<<<<.......>>>>>>.....<<)..(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>.. ((((.(((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((.....(((...)))......)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((...((.......(((((.(((..(((.........)))..)))........((........))..)))))...))...))))).))...........]]].)...))))))))))...)))))))((((.(..........).))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((.....((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....)))).........))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((.(......).(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((.(.((.............(..((...((......(((((((......)))))))...)).............))..)....)).).)))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).).....((.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..))....(.(((((....))).)).)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).)))).)))).. Cryo-EM structure of the E.coli 70S ribosome in complex with the antibiotic Myxovalargin B.; 23S ribosomal RNA 8b7y J 118 3.0 RF00001 URS0000366A67_83333 36603206 0003735 0005840 83333 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. ((((((.((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)).)))))). Cryo-EM structure of the E.coli 70S ribosome in complex with the antibiotic Myxovalargin B.; 5S ribosomal RNA 8b7y n 76 3.0 RF00005 URS00002905B5_83333 36603206 0030533 0006412 83333 gcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Cryo-EM structure of the E.coli 70S ribosome in complex with the antibiotic Myxovalargin B.; P-tRNA fMet 8b7y C 1519 3.0 RF00177,RF01959,RF02542,RF01960 URS000080E246_83333 36603206 0003735 0005840 83333 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugccggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggauca .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<......>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<.>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<.<......<..<....>.>......>.>>..<<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>>.<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<....<.<<<<<<.....>>>>>>.>..>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>.>..........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<..>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<........<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<..<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>.........>>>.........>>>...>>>>>>>>>...>>>>>>>......>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((.((............))..)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((.)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((.......((..(....).)).......))..((.(((((...(..(.(((.((((.......)))).))).)...)....)))))....)).((((([[[...(..((.....((.]]])).......))..))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((.(((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))..))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((((())))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))...(......)..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Cryo-EM structure of the E.coli 70S ribosome in complex with the antibiotic Myxovalargin B.; 16S ribosomal RNA 8bdr R 12 2.7 URS00026177BC_1334388 36596301 1334388 gaugaggcuauu ............ ............ Early transcription elongation state of influenza B/Mem polymerase backtracked due to double incoproation of nucleotide analogue T1106 and with singly incoporated T1106 at the U +1 position; 3' vRNA 8bdr M 19 2.7 36596301 1283191 aucuauaauagccucnucn ................... ................... Early transcription elongation state of influenza B/Mem polymerase backtracked due to double incoproation of nucleotide analogue T1106 and with singly incoporated T1106 at the U +1 position; mRNA 8be0 R 12 2.34 URS00026177C0_11520 36596301 11520 gacgaggcuauu ............ ............ Early transcription elongation state of influenza B/Mem polymerase backtracked due to double incoproation of nucleotide analogue T1106 and with singly incoporated T1106 at the C +1 position; 3' vRNA 8be0 M 20 2.34 36596301 11520 aucuauaauagccucnucnn .................... .................... Early transcription elongation state of influenza B/Mem polymerase backtracked due to double incoproation of nucleotide analogue T1106 and with singly incoporated T1106 at the C +1 position; mRNA 8bek M 17 2.86 36596301 11320 aucuauaauaguuunuu ................. ................. Early transcription elongation state of influenza A/H7N9 backtracked polymerase with singly incoporated T1106 at the U +1 position; mRNA 8bek R 17 2.86 URS00026177BE_11320 36596301 11320 ccucugaauaaacuauu ................. ................. Early transcription elongation state of influenza A/H7N9 backtracked polymerase with singly incoporated T1106 at the U +1 position; 3' vRNA 8bek V 14 2.86 URS000080E200_11320 36596301 11320 aguaguaacaagag .<<....>>..... .((....))..... Early transcription elongation state of influenza A/H7N9 backtracked polymerase with singly incoporated T1106 at the U +1 position; 5' vRNA 8bf5 R 12 2.96 URS00026177BA_11520 36596301 11520 aacugagaaagc ............ ............ Early transcription elongation state of influenza A/H7N9 polymerase stalled with incoming GTP analogue; 3' vRNA 8bf5 M 13 2.96 36596301 11520 aucugcuuucuca ............. ............. Early transcription elongation state of influenza A/H7N9 polymerase stalled with incoming GTP analogue; mRNA 8bf7 0 2758 2.33 RF02541 URS00004B0F34_83333 37553384 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggcuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<<..>>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<......<<...<<<.<<<<...<<.<..>..>>...>>>>.>>>..>>.......>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<..............>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<.<.<<<...<<<....>>>...>>>..>>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<<..>>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<....<<..>>.....>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.......<<<<<<.<<....>>..>>>>>>.......>>>>>>>>>..>>>>>.<<<<<.......>>>>>.........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<....>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((..()...))...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{......)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((...(((...(((....)))...)))...)))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((.((....).))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Elongating E. coli 70S ribosome containing deacylated tRNA(iMet) in the P-site and AAA mRNA codon with cognate dipeptidyl-tRNA(Lys) in the A-site; 23S rRNA RRLG-RRNA 8bf7 1 120 2.33 RF00001 URS0000049E57_83333 37553384 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Elongating E. coli 70S ribosome containing deacylated tRNA(iMet) in the P-site and AAA mRNA codon with cognate dipeptidyl-tRNA(Lys) in the A-site; 5S rRNA 8bf7 2 1534 2.33 RF00177,RF01959,RF02542,RF01960 URS00000ABFE9_83333 37553384 0003735 0005840 83333 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<.<<<<......>>>>.>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<<..>>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<......>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<.......<<<....>>>......>>>>...<.<<<<<.......<<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<........>>>................>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((..(..(....)..)..).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((.(....).))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).(((......)))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((((.......)))))))).....)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((....(........).......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.(..)))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..((((...(((.((((((......((........))..........(((((....(...(((((((...(.............)...............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.((.((((...((..(((.....)))))....)))).)).....(((((.....)))))........)))).....).).)))...)).)))))......)))))...)).)))).))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))...........(((((((........))))))).......)...)))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Elongating E. coli 70S ribosome containing deacylated tRNA(iMet) in the P-site and AAA mRNA codon with cognate dipeptidyl-tRNA(Lys) in the A-site; 16S rRNA RRSB-RRNA 8bf7 3 10 2.33 37553384 32630 auaaugaaau .......... .......... Elongating E. coli 70S ribosome containing deacylated tRNA(iMet) in the P-site and AAA mRNA codon with cognate dipeptidyl-tRNA(Lys) in the A-site; mRNA 8bf7 4 77 2.33 RF00005 URS000041AF00_83333 37553384 0030533 0006412 83333 cgcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(((((.......)))))))))))..... Elongating E. coli 70S ribosome containing deacylated tRNA(iMet) in the P-site and AAA mRNA codon with cognate dipeptidyl-tRNA(Lys) in the A-site; Deacylated P-site tRNA(fMet) 8bf7 5 76 2.33 RF00005 URS000042DDAB_83333 37553384 0030533 0006412 83333 gggucguuagcucagnnggnagagcaguugacunuunaucaauuggucgcaggnucgaauccugcacgacccacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).(((((.......))))).....(((((..]....)))))))))))).... Elongating E. coli 70S ribosome containing deacylated tRNA(iMet) in the P-site and AAA mRNA codon with cognate dipeptidyl-tRNA(Lys) in the A-site; Dipeptidyl A-site tRNA(Lys) 8bf9 5 1766 2.69 RF02543 URS000086853D_9940 37983950 0003735 0005840 9940 agcauauuagucagcggaggagaagugaacagggaagagcccagcgccaaucccgccccggcggggcggggacauguggcguacggaaggggcccaaguccuucugacgaggcgcccguggcgguggaggcgguagggccccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaacuuugaagagagaguucaagaggcgugaaaccguucgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucggggcucgcacgaaagcccguggcgcaaugagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccuggguauaggggcgaaagacuaacgaaccaucuaguagcugguucccuccggggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagcuuugaaggccgaguggagaaggguuccauguaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguucgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggggcggagauggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguuucuuuucuuuugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcugagcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagguuuuuucacugacccggugaggcgggggcgcuucuggcgccaagcgcccggccgcccggccggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuugugauccuucgaugucggcucuucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguaugugcuuggcugaggagccaauggggcgaagcuaccaucugug ......................................[[[...<<<<..<<<<<<<<<...>>>>>.>>>>.....>>>>...<<.....<<<<....<<<<.....>>>>..<<.....((.....>>))...>>>>>>.......<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]].................................<<....>>...........<<<<....>>>>...........................<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<.<<<<<........>>>>>..>>>.......>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<...<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>.>>>>>>>>...<<.......>>.....>>>>>>...>..>.>>..<<<....>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.....>>>>>>.<<<....<<<<<.<<...<<<<<<..<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>.........<<.<<<....<.....>....>>>>>......>>....>>>..<<<<<........>>>>>))<<<<.<<<<....<<<<<......>>>.>>...<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..{{..>>>>>>...<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>..>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<.<<<<<<<<<<....>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<...<<.....<<<<....>>>>.....>>.>>>>>..>>>>>.......<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....(((((..[[[.[[......((((.[[((((..<<<<<.<<<<<<<<<.<<<<<<<....>>>>>>>...<<<<<.....<<<<.................<<<.<<<<<<....>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>....>>>>>>....................))))..]])))).......<<.......>.>.......<<<<<.<....................>...>>>.>>....<<<<<<<....>>>.>>>>....]]..]]].))))).......<<.<<<<<<<}}..>>>>>..>>.>>................ ......................................((((...(((.((((((((((...))))).))))....))))....((.....((((..({((((.....))))).[[(...)((....}]]))...))))))..)....(((((((........))))))).....(((((..[[.[[[)))))..))).................................((....))...........((((....))))..........................[((((........))))((((((....(((((((((((((..(((.(((((........)))))..))).......)))))))))))))..((.(...((((((.....((((((((...((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).))).)))))))).(.((.......))..)..))))))......).))..(((....))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.....)))))).(((....((((..((...((((((..((.....)).))))))....[[(((.((...((..(.(((....)))....)....(..((((...((...))...)))).)......))....))...(((((........)))))]]((((.(((.....(((..(.....).).))..((((....)))...(...(((((....(((((((((((((((((((((((..{{..))))))...(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((...).))))))))))).).))))))))))))(...).....)))))...))............))).)))).)))..)).....((......)).))))..(((.....)))...)))....((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((..)))))..)))))).))(...).......(((.(((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...(......((((....))))......).)))))..))))).......((..........(((((.......)))))..)..)....)))....)).))).))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.(((((((((.(((((((....)))))))...(((((.....((((.................(((.((((((....)))))))))..))))..)))))....)))))))))..)))))..(((.......)).)..]]].]]....................))))..)))))).......((.......).)........((((.((................)..)...))).).....(((((((....))).))))..>.))..))).))))).......((.(((((((}}..)))))..)).))................ Molecular view of ER membrane remodeling by the Sec61/TRAP translocon.; RNA (1766) 8bf9 8 98 2.69 RF00002 URS00004B2C76_9940 37983950 0003735 0005840 9940 ucggcucgugcgucgaugaagaacgcagcagcugcgagaauuaaugugaauugcaggacacauugauuucgcacuugcggccccgggccggggcuacg ....................<<<<<<<((...>>>>................)).............>>><<....>><<<<<<<<.>>>>>>>>... ....................((((((.[[...[)))...]............]].............)))((....))((((((((.))))))))... Molecular view of ER membrane remodeling by the Sec61/TRAP translocon.; RNA (156-MER) 8bge 0 2758 2.11 RF02541 URS00004B0F34_83333 37553384 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggcuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<.))).....>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<.....<<<.<<<<...<<<<..>>.>>...>>>>.>>>.....>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<..............>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<<..>>>>>>...>>>>>>...>>>...>>>.>........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.......<<<<<<.<<....>>..>>>>>>.......>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<..>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<.)))..>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((((())).))...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{......)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((..)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Elongating E. coli 70S ribosome containing acylated tRNA(iMet) in the P-site and AAm6A mRNA codon in the A-site after uncompleted di-peptide formation; 23S rRNA RRLG-RRNA 8bge 1 120 2.11 RF00001 URS0000049E57_83333 37553384 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Elongating E. coli 70S ribosome containing acylated tRNA(iMet) in the P-site and AAm6A mRNA codon in the A-site after uncompleted di-peptide formation; 5S rRNA 8bge 2 1534 2.11 RF00177,RF01959,RF02542,RF01960 URS00000ABFE9_83333 37553384 0003735 0005840 83333 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<.<<<<<<....>>>>>>..>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<<..>>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>...<.<<<<<.......<<<<<<<<<.<...>.>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<........>>>................>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((...((.(....).))....)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((((.......)))))))).....)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((....(........).......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...(....(((...........)))....)))))))......{...((((((..((((((((((((.(..)))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..((((...((((((((((......((........))..........(((((....(...(((((((.....(........)......(..........)))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.((.((((...((..(((.....)))))....)))).))..(..(((((.....))))).....)..)))).....).).)))...)).)))))......)))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))...........(((((((........))))))).......)...)))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Elongating E. coli 70S ribosome containing acylated tRNA(iMet) in the P-site and AAm6A mRNA codon in the A-site after uncompleted di-peptide formation; 16S rRNA RRSB-RRNA 8bge 3 10 2.11 37553384 32630 auaaugaanu .......... .......... Elongating E. coli 70S ribosome containing acylated tRNA(iMet) in the P-site and AAm6A mRNA codon in the A-site after uncompleted di-peptide formation; mRNA 8bge 4 77 2.11 RF00005 URS000041AF00_83333 37553384 0030533 0006412 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Elongating E. coli 70S ribosome containing acylated tRNA(iMet) in the P-site and AAm6A mRNA codon in the A-site after uncompleted di-peptide formation; Acylated P-site tRNA(fMet) 8bgh 0 2758 2.88 RF02541 URS00004B0F34_83333 37553384 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggcuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...(((..<<<<....<.<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>.>..>>>>>>>>>>>>>..>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<..>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<..............>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<<..>>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<....<<..>>.....>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.......<<<<<<.<<....>>..>>>>>>.......>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<..<<..>>..>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<.)))..>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((..((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))))))..)))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((.().).))...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{......)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((.(((..)).))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Elongating E. coli 70S ribosome containing acylated tRNA(iMet) in the P-site and AAA mRNA codon in the A-site after uncompleted di-peptide formation; 23S rRNA RRLG-RRNA 8bgh 1 120 2.88 RF00001 URS0000049E57_83333 37553384 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Elongating E. coli 70S ribosome containing acylated tRNA(iMet) in the P-site and AAA mRNA codon in the A-site after uncompleted di-peptide formation; 5S rRNA 8bgh 2 1534 2.88 RF00177,RF01959,RF02542,RF01960 URS00000ABFE9_83333 37553384 0003735 0005840 83333 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<.<<<<<<....>>>>>>..>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<...<<<<<<.........>>>>>>.>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<.....<<<<<<<...<<<......>>>......>>>>>>>............<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<........>>>................>>>>>.>>.<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<.....>>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((.(.((.(....).)))...)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..(.((((((.......)))))).))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).......(((...(((((....)))).))))..)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((((.......)))))))).....)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((....(........).......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...(....(((...........)))....)))))))......{...((((((..((((((((((((.(..)))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..((((...((((((((((......((........))..........(((((....(...((((((....(.(........)..)...(..........).)))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.((.((((...((..(((.....)))))....)))).))..(..(((((.....))))).....)..)))).....).).)))...)).)))))......)))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))...........(((((((........))))))).......)...)))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Elongating E. coli 70S ribosome containing acylated tRNA(iMet) in the P-site and AAA mRNA codon in the A-site after uncompleted di-peptide formation; 16S rRNA RRSB-RRNA 8bgh 4 77 2.88 RF00005 URS000041AF00_83333 37553384 0030533 0006412 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Elongating E. coli 70S ribosome containing acylated tRNA(iMet) in the P-site and AAA mRNA codon in the A-site after uncompleted di-peptide formation; Acylated P-site tRNA(fMet) 8bh4 0 2758 2.62 RF02541 URS00004B0F34_83333 37553384 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggcuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<......<<...<<<.<<<<...<<.<..>..>>...>>>>.>>>..>>.......>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<..............>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<.<.<<<...<<<....>>>...>>>..>>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<<..>>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.......<<<<<<.<<....>>..>>>>>>.......>>>>>>>>>..>>>>>.<<<<<.......>>>>>.........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<..<....>..>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<.)))..>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((((())).))...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{......)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((...(((...(((....)))...)))...)))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((.((....).))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Elongating E. coli 70S ribosome containing deacylated tRNA(iMet) in the P-site and AAm6A mRNA codon with cognate dipeptidyl-tRNA(Lys) in the A-site; 23S rRNA RRLG-RRNA 8bh4 1 120 2.62 RF00001 URS0000049E57_83333 37553384 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Elongating E. coli 70S ribosome containing deacylated tRNA(iMet) in the P-site and AAm6A mRNA codon with cognate dipeptidyl-tRNA(Lys) in the A-site; 5S rRNA 8bh4 2 1534 2.62 RF00177,RF01959,RF02542,RF01960 URS00000ABFE9_83333 37553384 0003735 0005840 83333 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<.<<<<......>>>>.>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<....<<<<<<......>>>>>.>....>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<......>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<.......<<<<..>>>>......>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<..<<<<<..<<<<<<<<.<......<<........>>..........<<<<<<<......<<<<<<<...<<<........>>>................>>>>>.>>.<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>...>..>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>.....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>...... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((................).)))))..)))))......(((......(((((((...(...(.(((((.(.((.....((((.(....).))))......)).).....(((....)))....((((((..((....)))))))).))))).)..)..)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).(((.(...))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((((.......)))))))).....)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((.(((...((((((((....(((((((....(........).......)))))))....).......((....)).)))))))..)))..))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.(..)))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..((((...(((.((((((......((........))..........(((((....(...(((((((...(.............)...............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.((.((((...((..(((.....)))))....)))).)).....(((((.....)))))........)))).....).).)))...)).)))))......)))))...)).)))).))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))...........(((((((........))))))).......)...)))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Elongating E. coli 70S ribosome containing deacylated tRNA(iMet) in the P-site and AAm6A mRNA codon with cognate dipeptidyl-tRNA(Lys) in the A-site; 16S rRNA RRSB-RRNA 8bh4 3 10 2.62 37553384 32630 auaaugaanu .......... .......... Elongating E. coli 70S ribosome containing deacylated tRNA(iMet) in the P-site and AAm6A mRNA codon with cognate dipeptidyl-tRNA(Lys) in the A-site; mRNA 8bh4 4 77 2.62 RF00005 URS000041AF00_83333 37553384 0030533 0006412 83333 cgcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..(((...........))).(((((.......))))).....(((((.......)))))))))))..... Elongating E. coli 70S ribosome containing deacylated tRNA(iMet) in the P-site and AAm6A mRNA codon with cognate dipeptidyl-tRNA(Lys) in the A-site; Deacylated P-site tRNA(fMet) 8bh4 5 76 2.62 RF00005 URS000042DDAB_83333 37553384 0030533 0006412 83333 gggucguuagcucagnnggnagagcaguugacunuunaucaauuggucgcaggnucgaauccugcacgacccacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..))))((((((.......))))))....(((((..]....)))))))))))).... Elongating E. coli 70S ribosome containing deacylated tRNA(iMet) in the P-site and AAm6A mRNA codon with cognate dipeptidyl-tRNA(Lys) in the A-site; Dipeptidyl A-site tRNA(Lys) 8bhf 21 76 3.1 URS0002681486_9986 37653241 0030533 0006412 9986 accaggauggccuagugguuaaggcguuggacuuaagauccaauggacauguguccgcgucgguuuucgaacccca ....<<<..<<<<........>>>><<<<<<.......>>>>>>....<..<<.......>>..>>>>........ ....(.(..((((........)))).(((((.......))))).....(..((.......))..)).)........ Cryo-EM structure of stalled rabbit 80S ribosomes in complex with human CCR4-NOT and CNOT4; P-site tRNA 8bhf A2 3603 3.1 RF02543 URS0002681476_9986 37653241 0003735 0005840 9986 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggaaauguggcguacggaagacccacuccccggcgccggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcgcgguccggccgugccggcggggcggaucucccgcucccgucggcgggggaccgccccccggccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggccccggcggggaagguggcccgggggccccggguguuacagccccgccccggcagcagcagcucgccgaaucccggggccgagggagcgagacccgugcgccgcgcucuccccccucgggggggccgggccaccccucccacggcgcgaccgcuggggcggacuguccagugcgccccgggcgggucgcgccgucgggcccggggggccacgcgucccccgcgagcgcacggggucggcggcgaugucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcuacgaaagccgccguggcgcaaugaaggugaaggccggcggcgcgccgccggccgaggugggaucccgaggccuuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcgaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccaaaguuucccucaggauagcuggcgcucuccgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcugguguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggaugguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgcuggcagucggcagagcgagaaagagaguggcgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucagccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcuggcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacaugagagguguagaauaagugggaggcccgggccgccggugaaauaccacuacucugaucguuuuuucacugacccggugaggcgggggggcgagccgggcucucgcuucuggcgccaagcgcccggccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauagcgccggagccucgguuggccucggauagccggucccccgccgggguccggugcggagagcccuucgucccgggaaacggggcggccggaaagggggccgcccucucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcugcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..[[[...<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>...<<<<<<<<<....<<<<<<<<..<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>...>>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<.<....<<<<<<<<.<<<.....<<<<<<<<<.....<<<<<<<.<<<<<.<<<<<<<.<<<<<<<<<......>>>>>>>>>>>>>>>>>>>>>>>>>...>>>..>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<<<<<<<<<<<<.<<<<...<<..<<<...<<.<<<......<<<<<<<<.>>>>>>>>.......>>>.>>...>>>.........>>>>>>...>>>>>>>>>>.........................<...<<<<<<..>>>>>>...<.<<..<<<.<<<<<<<<<<<<<<<<<<<<<<<.<<<<..>>>>.>>>>>>.>>>>.>>>>>>>>>>.>>>...>>>>>.>................>........>>>.>>>>>....>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<.....>>>>.....>>>...<<....>>...<<<<<<..<<..>>..>>>>>>..<<<<<...<<<..<<<...(((.[[.>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<...<<<.<<<<<<<<<...<<<....<<<..<.<<<..<<<<<<.........>>>>>>>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<.....<.........>.....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<....................]].)))............>>>>>>>>>....>>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<<<<<...>>>>>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<..<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..{{{..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<.>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<<.<<<<<<<<.....<<<<..........<<<<<...<<<..>>>.............>>>>>.>>>>......>>>>>>>>...<<<<<.....<<<<..<<.<..<..>..>.>>..............<<<<<<<<<..>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>><<<<....>>>>>>)))]......((((((..(((..>>>>>>.)))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]].....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<}}}.>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.<<<<<<<..<<<<....<<<........<<<<<..<<<<<.>>>>>.>>>>>.......>>>...<<<..<<<<....<<<<<<<<<........>>>>>>.>>>...>>>>..>>>..............>>>>..>.>>>>>>.<<<<<.<.............>....<<.<<<<<<<.<<.....<<<<.<..<<<<<.>>>>>..>>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..(((((((((((.....)))))).))))....))))....(((((((((....(.((((((..((((((((..({((((......)))))....[[(...).(((....}]])))...).)))))))...)))))).)...)))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....(((((((((..(..(((((((.(((((.(((((((.(((((((((......)))))))))))))))))))))))))...)))).)))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((..((..(((......((((.(((.)).))))).......))))..)..))).........))))))..)))))))))))......(.....{.)........(.(...(((((.().)))))...(.((..(((.(((((((((((((((..((((((.((((..)))).))))))...).))))))))))).)))...))))).)............[...)..).....))).)))))...)))))...)))))))).<((((........))))((((((....(((((((((((((..(((..((((.......)))..)..)))...((....))...(((((((.((..)).)))))))..(((((...(((..(((]...[[.[[[)))..)))....))))).(((((((((.((((......))))))))))).))....)))))))))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)<)))...(((..((.((.......B)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((...(((.((((((((....(((....(((..(.(((..(((.((.........)).)))))).)..)))..)).)....))))))...(((((((((.(......))))))))))....))))))))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.....A.((.((.(((...................))).........((......))...)).))...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((........}.........].]].]].............)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...((..(.(((....))).....)....((.((((.((((...)))).))))))......))....))...(((((........)))))]]((((....(((((...(((((((....)))))))..((((....)))...(...((((((...(((((((((((((((((((((((...{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((.)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.(((((((((.(((((((.(....((((..........(.(((....((..))..............))).).)))).....).)))))))...(((((.....((((..((.(..(..)..).))..............(((((((((())))))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..b.))..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}..)))))..)).))...))))...)))).((((...((((.....a.......))))...))))..)))...).)))))).(((((((..((((....(((.........((((...((((.))))..))))........)))...(((..(((.....(.(.(((((........)))))..).)....)))..)))..............))))..).)))))).(((((.(..(.......)..)....((.(((((((.((.....((((.(..(((((.)))))..)))))....))....)))).))).))..))))).. Cryo-EM structure of stalled rabbit 80S ribosomes in complex with human CCR4-NOT and CNOT4; 28S ribosomal RNA 8bhf B2 119 3.1 RF00001 URS000064027A_9986 37653241 0003735 0005840 9986 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))). Cryo-EM structure of stalled rabbit 80S ribosomes in complex with human CCR4-NOT and CNOT4; 5S ribosomal RNA 8bhf C2 151 3.1 RF00002,RF02540 URS00004B2C76_9986 37653241 0003735 0005840 9986 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcagguugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<<<<....>>>>.....<.<<<......>>........>>>..>...>>>....<<<..>>><<<<<<<<.......>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]]........)))..)...)))....((....))((((((((.......)))))))).................... Cryo-EM structure of stalled rabbit 80S ribosomes in complex with human CCR4-NOT and CNOT4; 5.8S ribosomal RNA 8bhf A3 1697 3.1 RF01960,RF02542,RF01959,RF00177 URS0000D56C41_9986 37653241 0003735 0005840 9986 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucgacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgcccggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcggccguccccugcucggcgccggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgaccccggucggcguaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggugcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<....<<....<<<<<........<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<<<....>>>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<<.>>>>>>>>.>>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....<<<<<<<<<.<<<....>>>..>>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<....<<<.<<<..>>>.>>><<<<<<<..<..>.>>>>.>>>.<<<<<<.<.......<<...<.......>.<<<<.>>>>...>>......>.>>>..>>>........<.<<.<<<<<<<...............>>>>>>>.>>.>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<<....>>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<.......<<........>>..........<<<<<.<....<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<..>>>>.>>>>>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.....>.>>>>>....>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>............<<<<<..........>>>>>...........>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<.<<<<<<<<<..>>>>>>>>>...>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..(.....(((.....((...((.....((.(((.....))).))......))......)).((((...((((((....))))))...))))((..(((((...(......)..)))))......)).(.((((.((((.)))))))))...)))....)).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).).....(((((((((.(((....)))..)))))).)))....(.((..(...........)..))......)..((((([[......((((.....((..]])).......)))).)))))..)))))).)))..[......(.([[...(.(.((...(((..(....(((.(((()))).))).(.(((.........)))..)..((((((.(.......((..((.......)).(((.)))....))......).)))..)))........(.((.((((((.................)))))).)).)....)....(((..(...(...((((..(((.((((((((...((........))......)))))))).))).......((....))...))))..)...)...))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.(((((....))))))))))).)..)))...((..]]))...))...].))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((..((........))..))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((...(...((((..((((((((((((..)))).))))))))..))))..).....(((((.....)))))........)))....))).))).....).))))).....).)))))...)).)))).))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..((((.((...((((((((((((.(....).)))))).).)))))...)).))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}........ Cryo-EM structure of stalled rabbit 80S ribosomes in complex with human CCR4-NOT and CNOT4; 18S ribosomal RNA 8bhj 0 2758 2.81 RF02541 URS00004B0F34_83333 37553384 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggcuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<....<.<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>..>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<......<<...<<<.<<<<...<<.<...>.>>...>>>>.>>>..>>.......>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<..............>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<.<.<<<...<<<....>>>...>>>..>>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.......<<<<<<.<<....>>..>>>>>>.......>>>>>>>>>..>>>>>.<<<<<.......>>>>>.........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<........>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((....).))...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{......)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((...(((...(((....)))...)))...)))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((.(.......))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Elongating E. coli 70S ribosome containing deacylated tRNA(iMet) in the P-site and Am6AA mRNA codon with cognate dipeptidyl-tRNA(Lys) in the A-site; 23S rRNA RRLG-RRNA 8bhj 1 120 2.81 RF00001 URS0000049E57_83333 37553384 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(.(((((...(.....)...))))..).)...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Elongating E. coli 70S ribosome containing deacylated tRNA(iMet) in the P-site and Am6AA mRNA codon with cognate dipeptidyl-tRNA(Lys) in the A-site; 5S rRNA 8bhj 2 1534 2.81 RF00177,RF01959,RF02542,RF01960 URS00000ABFE9_83333 37553384 0003735 0005840 83333 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<..<<<<......>>>>...>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<....<<<<<<......>>>>>.>....>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<......>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<.......<<<<..>>>>......>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<........>>>................>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ........((((..[.[[[..)))).((.(.(((((..(((((((((....(((.(((..(((..((.((..((((................).)))))..)))))......(((......(((((((...(...(.(((((.(.((.....((((.(....).))))......)).).....(((....)))....((((((..((....)))))))).))))).)..)..)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).(((.(...))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....(((.((((.......)))).))).....)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))).))..........((([[.....((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((....(........).......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.(..)))))))))))))...((..]])).....)))))).))).(((......((((....))))....)))...]]].](((((.(((((((.((..((((...(((.((((((......((........))..........(((((....(...(((((((...(.............)...............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.((.((((...((..(((.....)))))....)))).)).....(((((.....)))))........)))).....).).)))...)).)))))......)))))...)).)))).))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))...........(((((((........))))))).......)...)))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Elongating E. coli 70S ribosome containing deacylated tRNA(iMet) in the P-site and Am6AA mRNA codon with cognate dipeptidyl-tRNA(Lys) in the A-site; 16S rRNA RRSB-RRNA 8bhj 3 10 2.81 37553384 32630 auaauganau .......... .......... Elongating E. coli 70S ribosome containing deacylated tRNA(iMet) in the P-site and Am6AA mRNA codon with cognate dipeptidyl-tRNA(Lys) in the A-site; mRNA 8bhj 4 77 2.81 RF00005 URS000041AF00_83333 37553384 0030533 0006412 83333 cgcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..(((...........))).(((((.......))))).....(((((.......)))))))))))..... Elongating E. coli 70S ribosome containing deacylated tRNA(iMet) in the P-site and Am6AA mRNA codon with cognate dipeptidyl-tRNA(Lys) in the A-site; Deacylated P-site tRNA(fMet) 8bhj 5 76 2.81 RF00005 URS000042DDAB_83333 37553384 0030533 0006412 83333 gggucguuagcucagnnggnagagcaguugacunuunaucaauuggucgcaggnucgaauccugcacgacccacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((.(.....[..).))((((((.......))))))....(((((..]....)))))))))))).... Elongating E. coli 70S ribosome containing deacylated tRNA(iMet) in the P-site and Am6AA mRNA codon with cognate dipeptidyl-tRNA(Lys) in the A-site; Dipeptidyl A-site tRNA(Lys) 8bhl 0 2758 2.21 RF02541 URS00004B0F34_83333 37553384 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggcuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<.....<<<.<<<<...<<<<..>>.>>...>>>>.>>>.....>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<..............>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<<..>>>>>>...>>>>>>...>>>...>>>.>........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.......<<<<<<.<<....>>..>>>>>>.......>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<..>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<.)))..>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((.().).))...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{......)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((..)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Elongating E. coli 70S ribosome containing acylated tRNA(iMet) in the P-site and Am6AA mRNA codon in the A-site after uncompleted di-peptide formation; 23S rRNA RRLG-RRNA 8bhl 1 120 2.21 RF00001 URS0000049E57_83333 37553384 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Elongating E. coli 70S ribosome containing acylated tRNA(iMet) in the P-site and Am6AA mRNA codon in the A-site after uncompleted di-peptide formation; 5S rRNA 8bhl 2 1534 2.21 RF00177,RF01959,RF02542,RF01960 URS00000ABFE9_83333 37553384 0003735 0005840 83333 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<.<<<<<<....>>>>>>..>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<<..>>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>...<.<<<<<.......<<<<<<<<<.<...>.>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<........>>>................>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((...((.(....).))....)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(..(.((((((((.......)))))))).)...)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((....(........).......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...(....(((...........)))....)))))))......{...((((((..((((((((((((.(..)))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..((((...((((((((((......((........))..........(((((....(...(((((((.....(........)......(..........)))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.((.((((...((..(((.....)))))....)))).))..(..(((((.....))))).....)..)))).....).).)))...)).)))))......)))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))...........(((((((........))))))).......)...)))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Elongating E. coli 70S ribosome containing acylated tRNA(iMet) in the P-site and Am6AA mRNA codon in the A-site after uncompleted di-peptide formation; 16S rRNA RRSB-RRNA 8bhl 3 10 2.21 37553384 32630 auaauganau .......... .......... Elongating E. coli 70S ribosome containing acylated tRNA(iMet) in the P-site and Am6AA mRNA codon in the A-site after uncompleted di-peptide formation; mRNA 8bhl 4 77 2.21 RF00005 URS000041AF00_83333 37553384 0030533 0006412 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Elongating E. coli 70S ribosome containing acylated tRNA(iMet) in the P-site and Am6AA mRNA codon in the A-site after uncompleted di-peptide formation; Acylated P-site tRNA(fMet) 8bhn 0 2758 2.85 RF02541 URS00004B0F34_83333 37553384 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggcuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<<..>>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<......<<...<<<.<<<<...<<.<..>..>>...>>>>.>>>..>>.......>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<..............>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><<<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>.>>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<.<.<<<...<<<....>>>...>>>..>>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<<..>>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.......<<<<<<.<<....>>..>>>>>>.......>>>>>>>>>..>>>>>.<<<<<.......>>>>>.........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<.<....>.>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((..(.)..))...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{......)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((...(((...(((....)))...)))...)))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((.(.......))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Elongating E. coli 70S ribosome containing deacylated tRNA(iMet) in the P-site and m6AAA mRNA codon with cognate dipeptidyl-tRNA(Lys) in the A-site; 23S rRNA RRLG-RRNA 8bhn 1 120 2.85 RF00001 URS0000049E57_83333 37553384 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Elongating E. coli 70S ribosome containing deacylated tRNA(iMet) in the P-site and m6AAA mRNA codon with cognate dipeptidyl-tRNA(Lys) in the A-site; 5S rRNA 8bhn 2 1534 2.85 RF00177,RF01959,RF02542,RF01960 URS00000ABFE9_83333 37553384 0003735 0005840 83333 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<.<<<<......>>>>.>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<<....>>>>>>......>>.>.....<<<....>>>....<<<<<<..<<<..>>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<......>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<.......<<<<..>>>>......>>>>...<.<<<<<......<.<<<<<<<<.<...>.>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<........>>>................>>>>>.>>.<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((..(..........)..).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((.(....).))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).(((......)))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((((.......)))))))).....)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((....(........).......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.(..)))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..((((...(((.((((((......((........))..........(((((....(...(((((((...(.............)...............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.((.((((...((..(((.....)))))....)))).)).....(((((.....)))))........)))).....).).)))...)).)))))......)))))...)).)))).))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))...........(((((((........))))))).......)...)))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Elongating E. coli 70S ribosome containing deacylated tRNA(iMet) in the P-site and m6AAA mRNA codon with cognate dipeptidyl-tRNA(Lys) in the A-site; 16S rRNA RRSB-RRNA 8bhn 3 10 2.85 37553384 32630 auaaugnaau .......... .......... Elongating E. coli 70S ribosome containing deacylated tRNA(iMet) in the P-site and m6AAA mRNA codon with cognate dipeptidyl-tRNA(Lys) in the A-site; mRNA 8bhn 4 77 2.85 RF00005 URS000041AF00_83333 37553384 0030533 0006412 83333 cgcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca .<<<<<...<<<<.........>>>>.<<<<<.......>>>>.>....<<<<<.......>>>>>.>>>>>..... .((((((..((((.........)))).(((((.......))))).....(.(((.......))).)))))))..... Elongating E. coli 70S ribosome containing deacylated tRNA(iMet) in the P-site and m6AAA mRNA codon with cognate dipeptidyl-tRNA(Lys) in the A-site; Deacylated P-site tRNA(fMet) 8bhn 5 76 2.85 RF00005 URS000042DDAB_83333 37553384 0030533 0006412 83333 gggucguuagcucagnnggnagagcaguugacunuunaucaauuggucgcaggnucgaauccugcacgacccacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>.>....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..))))..((((.......))))......(((((..]....)))))))))))).... Elongating E. coli 70S ribosome containing deacylated tRNA(iMet) in the P-site and m6AAA mRNA codon with cognate dipeptidyl-tRNA(Lys) in the A-site; Dipeptidyl A-site tRNA(Lys) 8bhp 0 2758 2.37 RF02541 URS00004B0F34_83333 37553384 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggcuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<<..>>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<.....<<<.<<<<...<<<<..>>.>>...>>>>.>>>.....>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<..............>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><<<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>.>>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<<..>>>>>>...>>>>>>...>>>...>>>.>........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.......<<<<<<.<<....>>..>>>>>>.......>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<..>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<.)))..>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((((())).))...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{......)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((..)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Elongating E. coli 70S ribosome containing acylated tRNA(iMet) in the P-site and m6AAA mRNA codon in the A-site after uncompleted di-peptide formation; 23S rRNA RRLG-RRNA 8bhp 1 120 2.37 RF00001 URS0000049E57_83333 37553384 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Elongating E. coli 70S ribosome containing acylated tRNA(iMet) in the P-site and m6AAA mRNA codon in the A-site after uncompleted di-peptide formation; 5S rRNA 8bhp 2 1534 2.37 RF00177,RF01959,RF02542,RF01960 URS00000ABFE9_83333 37553384 0003735 0005840 83333 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<.<<<<<<....>>>>>>..>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<.......<<<<..>>>>......>>>>...<.<<<<<.......<<<<<<<<<.<...>.>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<........>>>................>>>>>.>>.<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((...((.(....).))....)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(..(.((((((((.......)))))))).)...)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((....(........).......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...(....(((...........)))....)))))))......{...((((((..((((((((((((.(..)))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..((((...((((((((((......((........))..........(((((....(...(((((((.....(........)......(..........)))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.((.((((...((..(((.....)))))....)))).))..(..(((((.....))))).....)..)))).....).).)))...)).)))))......)))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))...........(((((((........))))))).......)...)))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Elongating E. coli 70S ribosome containing acylated tRNA(iMet) in the P-site and m6AAA mRNA codon in the A-site after uncompleted di-peptide formation; 16S rRNA RRSB-RRNA 8bhp 3 10 2.37 37553384 32630 auaaugnaau .......... .......... Elongating E. coli 70S ribosome containing acylated tRNA(iMet) in the P-site and m6AAA mRNA codon in the A-site after uncompleted di-peptide formation; mRNA 8bhp 4 77 2.37 RF00005 URS000041AF00_83333 37553384 0030533 0006412 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Elongating E. coli 70S ribosome containing acylated tRNA(iMet) in the P-site and m6AAA mRNA codon in the A-site after uncompleted di-peptide formation; Deacylated P-site tRNA(fMet) 8bil 0 2758 2.04 RF02541 URS00004B0F34_83333 37553384 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggcuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<<..>>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<.....<<<.<<<<...<<<<..>>.>>...>>>>.>>>.....>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<..............>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<<..>>>>>>...>>>>>>...>>>...>>>.>........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.......<<<<<<.<<....>>..>>>>>>.......>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<..>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......((((.((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))).))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((.().).))...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{......)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((..)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Initiation complex of the E. coli 70S ribosome with mRNA containing AAA codon in the A-site.; 23S rRNA RRLG-RRNA 8bil 1 120 2.04 RF00001 URS0000049E57_83333 37553384 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Initiation complex of the E. coli 70S ribosome with mRNA containing AAA codon in the A-site.; 5S rRNA 8bil 2 1534 2.04 RF00177,RF01959,RF02542,RF01960 URS00000ABFE9_83333 37553384 0003735 0005840 83333 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<.<<<<<<....>>>>>>..>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>...<.<<<<<......<<<<<<<<<<.<...>.>>>>>>>>.>>.......>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<........>>>................>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((...((.(....).))....)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((((.......)))))))).....)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((....(........).......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...(....(((...........)))....)))))))......{...((((((..((((((((((((.(..)))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..((((...((((((((((......((........))..........(((((....(...(((((((.....(........)......(..........)))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.((.((((...((..(((.....)))))....)))).))..(..(((((.....))))).....)..)))).....).).)))...)).)))))......)))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))...........(((((((........))))))).......)...)))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Initiation complex of the E. coli 70S ribosome with mRNA containing AAA codon in the A-site.; 16S rRNA RRSB-RRNA 8bil 3 10 2.04 37553384 32630 auaaugaaau .......... .......... Initiation complex of the E. coli 70S ribosome with mRNA containing AAA codon in the A-site.; mRNA 8bil 4 77 2.04 RF00005 URS000041AF00_83333 37553384 0030533 0006412 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Initiation complex of the E. coli 70S ribosome with mRNA containing AAA codon in the A-site.; Acylated P-site tRNA(fMet) 8bim 0 2758 2.04 RF02541 URS00004B0F34_83333 37553384 0003735 0005840 83333 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggcuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<<..>>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<..>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<..............>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><<<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>.>>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<<..>>>>>>...>>>>>>...>>>...>>>.>........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.......<<<<<<.<<....>>..>>>>>>.......>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<..>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<.)))..>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((((())).))...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{......)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((..)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Initiation complex of the E. coli 70S ribosome with mRNA containing AAm6A codon in the A-site; 23S rRNA RRLG-RRNA 8bim 1 120 2.04 RF00001 URS0000049E57_83333 37553384 0003735 0005840 83333 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Initiation complex of the E. coli 70S ribosome with mRNA containing AAm6A codon in the A-site; 5S rRNA 8bim 2 1534 2.04 RF00177,RF01959,RF02542,RF01960 URS00000ABFE9_83333 37553384 0003735 0005840 83333 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<.<<<<<<....>>>>>>..>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<<..>>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<.......<<<<..>>>>......>>>>...<.<<<<<.......<<<<<<<<<.<...>.>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<........>>>................>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((...((.(....).))....)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((((.......)))))))).....)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((....(........).......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...(....(((...........)))....)))))))......{...((((((..((((((((((((.(..)))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..((((...((((((((((......((........))..........(((((....(...(((((((.....(........)......(..........)))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.((.((((...((..(((.....)))))....)))).))..(..(((((.....))))).....)..)))).....).).)))...)).)))))......)))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))...........(((((((........))))))).......)...)))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Initiation complex of the E. coli 70S ribosome with mRNA containing AAm6A codon in the A-site; 16S rRNA RRSB-RRNA 8bim 3 10 2.04 37553384 32630 auaaugaanu .......... .......... Initiation complex of the E. coli 70S ribosome with mRNA containing AAm6A codon in the A-site; mRNA 8bim 4 77 2.04 RF00005 URS000041AF00_83333 37553384 0030533 0006412 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Initiation complex of the E. coli 70S ribosome with mRNA containing AAm6A codon in the A-site; Acylated P-site tRNA(fMet) 8bip C4 121 3.1 RF00001 URS000055688D_4932 37079644 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Structure of a yeast 80S ribosome-bound N-Acetyltransferase B complex; 5S rRNA 8bip C3 158 3.1 RF00002 URS00001BF64E_4932 37079644 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Structure of a yeast 80S ribosome-bound N-Acetyltransferase B complex; 5.8S rRNA 8bip 1 3301 3.1 RF02543 URS00026813B8_4932 37079644 0003735 0005840 4932 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaugguguuuuguauuucacuggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguagugagagccuuggucagacgcagcgggcgugcuuguggacugcuugguggggcuugcucugcuaggcggacuacuugcgugccuuguuguagacggccuuggucuugcuacaauuaacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauagagggcuaccuuuauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[...........<<.<<<<<<...>>>>>>.>>.............<<<<<<.<<<<<<<<<<<<<<<<<<<<<.....<<<<......>>>>.(.......<<<......)>>>....>>>>>>>>>..>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<.........................<<<<<<<.<<<<<<<<<<<<<<<......<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>...>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>(><<<<<<<<<<....<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>..>>>>>>>>.>>).<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<..........>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<<<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>.>.>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<...............>>>>><<.<<<<<<<<<<<.<<<<<<......<.<<<.....<<....<<.<<<<..<<<<.<<<<..<<<<<<<....>>>>>>>..>>>>.>>>>..>>>>.>>.....>>.....>>>..>....>>>>>>......>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.....<<.....<<<<....>>>>.....>>..>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<<<<<<<<<....>>>>>>>.>>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>..>>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((.(((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))).....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.(((((.........................(((((((((((((((((((((((.......(((((((......((((........)))).......))))))).....))))).))))))))))........(((....)))....)))))))).....))))).))))).[((((........))))((((((....((((((.((((((..(((..((((.......))))..)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((....((.(((((((.....(((....(((..(.((((...((((((.....)))))).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........(((...(.....)....)))....))....))...(((((........)))))]]((((.((((.(((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....)))...)))))))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((.((((..((....(.((............((..(((..((((.(.((.(((..(.(....).)..))).)).).))))..)))..)).............))..)..))..))))......)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..((.((((.(((((((((....))))))).)).)))).))....((((.....((((..((((........))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).))))).....(((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))........((((((.(((.((....((.(........((((.((..).).)))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Structure of a yeast 80S ribosome-bound N-Acetyltransferase B complex; 25S rRNA 8bjq C4 121 3.8 RF00001 URS000055688D_4932 37079644 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Structure of a yeast 80S ribosome-bound N-Acetyltransferase B complex; 5S rRNA 8bjq C3 158 3.8 RF00002 URS00001BF64E_4932 37079644 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Structure of a yeast 80S ribosome-bound N-Acetyltransferase B complex; 5.8S rRNA 8bjq 1 3301 3.8 RF02543 URS00026813B8_4932 37079644 0003735 0005840 4932 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaugguguuuuguauuucacuggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguagugagagccuuggucagacgcagcgggcgugcuuguggacugcuugguggggcuugcucugcuaggcggacuacuugcgugccuuguuguagacggccuuggucuugcuacaauuaacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauagagggcuaccuuuauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[...........<<.<<<<<<...>>>>>>.>>.............<<<<<<.<<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<.........................<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<....<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>..>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<..........>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<<<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>.>.>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<.<<<<<<<<<<<.<<<<<<.<....<.<<<.....<.....<<..<<<..<<<<.<<<<.......<<....>>.......>>>>.>>>>..>>>..>>......>.....>>>..>..>.>>>>>>......>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.....<<.....<<<<....>>>>.....>>..>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<<<<<<<<<....>>>>>>>.>>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>..>>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((.(((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))).....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((........................(((((((((((((((((((((((.......(((((((......((((.(....).)))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((..((((.......))))..)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((....((.(((((((.....(((....(((..(.((((...((((((.....)))))).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........(((((.(.....)..)))))....))....))...(((((........)))))]]((((.((((.(((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....)))...)))))))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((.((((..((....(.((............((..(((..((.(.(.((.(..................).)).).).))..)))..)).............))..)..))..))))......)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..((.((((((((((((((....))))))).))))))).))....((((.....((((..((((........))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(((.((..)..).)))..)))))...)))....)))).)))))).))))).. Structure of a yeast 80S ribosome-bound N-Acetyltransferase B complex; 25S rRNA 8bn3 3 121 2.4 RF00001 URS000055688D_4932 38324474 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Yeast 80S, ES7s delta, eIF5A, Stm1 containing; 5S ribosomal RNA 8bn3 4 158 2.4 RF00002 URS00001BF64E_4932 38324474 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Yeast 80S, ES7s delta, eIF5A, Stm1 containing; 5.8S ribosomal RNA 8bn3 1 3143 2.4 RF02543 URS00029156E2_4932 38324474 0003735 0005840 4932 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........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..<<<..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<<.<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<..<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<......>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<..<.<<<<...<<<<<<.....>>>>>>.>>>>.>..>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.......<<.........>>............................>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..[[[..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<<....>>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<...............>>>>><<.<<<<<<<<<..>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<...<<.....<<<<....>>>>.....>>.>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<..<<<<<<<<<<.......>>>>>>>>>>...<<<<<.....<<<<..<<<<........>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))......<<<<<<<..<<<<.))))))>>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<<]]].>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<.<..<<<<<......>>>>>..>>>>>...>>>....>>>>.>>>>>..>>>>>.. 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Yeast 80S, ES7s delta, eIF5A, Stm1 containing; 25S ribosomal RNA 8bn3 2 1737 2.4 RF01960,RF02542,RF01959,RF00177 URS000291567B_4932 38324474 0003735 0005840 4932 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...<<<<<.{.((((>>>>><<<<.<<<<<<...<.<...<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<..<<..<<....<<<..................<.....<<.<<.......>>.>>......>.........<<<<<..<......>..>>>>><...<<<<<<......((....{.........................>>>>>>.....>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>..>>>..>....>.>.....<<<..<<<<..<......>..>>>>...>>>......<<..<...........>..>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>>>>>.........<<<[[.....<.<<...<<<.<<....<<<<<<.<<<<<............>>>>>.>>>>>>....<<<<<.....<.....................>.....>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........<<<..<<<<<<<<.....}....)).>>>>>>>>.>>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>.>.>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<....>>>>>>>..>>>...<<..]]>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..)))).}<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<.......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>.....>.>>>>>....>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<...>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>....... 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Yeast 80S, ES7s delta, eIF5A, Stm1 containing; 18S ribosomal RNA 8bpo A1 3543 2.8 RF02543 URS000268142E_9986 37295431 0003735 0005840 9986 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggaaauguggcguacggaagacccacuccccggcgccggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcgcgguccggccgugccggcggggcggaucucccgcucccgucggcgggggaccgccccccggccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggccccggcggggaagguggcccgggggccccggguguuacagccccgccccggcagcagcagcucgccgaaucccggggccgagggagcgagacccgugcgccgcgcucuccccccucgggggggccgggccaccccucccacggcgcgaccgcuggggcggacuguccagugcgccccgggcgggucgcgccgucgggcccggggggccacgcgucccccgcgagcgcacggggucggcggcgaugucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcuacgaaagccgccguggcgcaaugaaggugaaggccggcggcgcgccgccggccgaggugggaucccgaggccuuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcgaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccaaaguuucccucaggauagcuggcgcucuccgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcugguguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggaugguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgcuggcagucggcagagcgagaaagagaguggcgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucagccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcuggcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacguuuuuucacugacccggugaggcgggggggcgagccgggcucucgcuucuggcgccaagcgcccggccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauagcgccggagccucgguuggccucggauagccggucccccgccgggguccggugcggagagcccuucgucccgggaaacggggcggccggaaagggggccgcccucucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcugcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..[[[..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>>..<<<<<<<<<....<<<<<<<<..<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>...>>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<.<....<<<<<<<<.<<<.....<<<<<<<<<<....<<<<<<<.<<<<<.<<<<<<<.<<<<<<<<<......>>>>>>>>>>>>>>>>>>>>>>>>>...>>>.>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<<<<<<<<<<<<.<<<<...<<..<<<..<<<<<<<......<<<<<<<...>>>>>>>.......>>>>>>>..>>>.........>>>>>>...>>>>>>>>>>.....<<.......>>.........<...<<<<<<..>>>>>>...<.<<..<<<.<<<<<<<<<<<<<<<<<.<<<<<.<<<<..>>>>.>>>>>..>>>.>>>>>>>>>>>.>>>...>>>>>.>................>........>>>.>>>>>....>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<.....>>>>.....>>>...<<....>>...<<<<<<<<<<..>>>>>>>>>>..<<<<<...<<<..<<<...(((.[[.>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<...<<<.<<<<<<<<<...<<<....<<<..<.<<<..<<<<.<.<.....>.>.>>>>>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>......................>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<....................]].)))............>>>>>>>>>....>>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<<<<<...>>>>>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<..<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<<<<<<<<<<<<..{{{..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>.>.>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<.>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<<.<<<<<<<<....>>>>>>>>...<<<<<.....<<<<..<<.<.<<..>.>>.>>..............<<<<<<<<<..>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>>.<<<....>>>.>>)))]......((((((..(((..>>>>>>.)))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]].....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<}}}.>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.<<<<<<...<<<<....<<<........<<<<<...<<<<.>>>>..>>>>>.......>>>...<<<..<<<<....<<<<<<<<<........>>>>>.>>>>...>>>>..>>>..............>>>>....>>>>>>.<<<<<.<.............>....<<.<<<<<<<.<<.....<<<<....<<<<<.>>>>>...>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..((((((((.((.....)).))).))))....))))....(((((((((....((((((((..((((((((..({((((......)))))....[[(...).(((....}]])))...).)))))))...))))))))...)))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....((((((((((.(..(((((((.(((((.(((((((.((.(...((......))...).))))))))))))))))))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((..(((((((......((((((.(.).)))))).......)))))))..))).........))))))..))))))))))).....((.....{.)).............((((((()))))))...(.((...((.((((((((((((((.(..(((((.((((..)))).)))))...)..))))))))))).)))...)).)).)............[............))).)))))...)))))...)))))))).<((((........))))((((((....(((((((((((((..(((..((((.......)))..)..)))...((....))...((((((((((..))))))))))..(((((...(((..(((]..[[[.[[[)))..)))....))))).(((((((((.((((......))))))))))).))....)))))))))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)<)))...(((..((.((.......B)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((...(((.((((((((....(((....(((..(.(((..(((.(...........).)))))).)..)))..)).)....))))))...(((((((((.(......))))))))))....))))))))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.....A...((...((...................))...........(......).....)).....)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((........}.........].]].]]]............)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...((..(.(((....))).....)....((.((((.(.((...)).).))))))......))....))...(((((........)))))]]((((....(((((...(((((((....)))))))..((((....)))...(...((((((...(((((((((((((((((((((((...{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((.)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(..(((.....((((....)))).....))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.(((((((((.(((((.(.(()).).)))))...(((((.....((((..(.....(..).....)..............(((((.(((()))).)))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..b.))..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}..)))))..)).))...))))...)))).((((...((((.....a.......))))...))))..)))...).)))))).(((((((..((((....(((.........((((...((((.))))..))))........)))...(((..(((......((..((((........))))...)).....)))..)))..............))))..).)))))).(((((.(..(.......)..)....((.(((((((.((.....((((.(..(((((.)))))..)))))....))....)))).))).))..))))).. Structure of rabbit 80S ribosome translating beta-tubulin in complex with tetratricopeptide protein 5 (TTC5) and S-phase Cyclin A Associated Protein residing in the ER (SCAPER); 28S ribosomal RNA 8bpo B1 120 2.8 RF00001 URS000002B0D5_9986 37295431 0003735 0005840 9986 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. Structure of rabbit 80S ribosome translating beta-tubulin in complex with tetratricopeptide protein 5 (TTC5) and S-phase Cyclin A Associated Protein residing in the ER (SCAPER); 5S ribosomal RNA 8bpo C1 151 2.8 RF00002,RF02540 URS00004B2C76_9986 37295431 0003735 0005840 9986 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcagguugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<<<<....>>>>.....<.<<<......>>........>>>..>...>>>....<<<..>>><<<<<<<<.......>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]]........)))..)...)))....((....))((((((((.......)))))))).................... Structure of rabbit 80S ribosome translating beta-tubulin in complex with tetratricopeptide protein 5 (TTC5) and S-phase Cyclin A Associated Protein residing in the ER (SCAPER); 5.8S ribosomal RNA 8bqd 2 1771 3.9 RF01960,RF02542,RF01959,RF00177 URS0001A16A88_4932 37079644 0003735 0005840 4932 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugagcuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauu ...<<<<<...((((>>>>><<<<.<<<<<<...<.<...<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<..<<..<<....<<<..................<<....<<.<<<.....>>>.>>.....>>.........<<<<<..<<....>>..>>>>><.<.<<<<<<......[[.((((.<<<....>>>....<<......>>>>>>>>.>...>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>..>>>..>....>.>.....<<<<<<<.<<<<<....>>>>>.>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>>.........<<<{{.....<.<<...<<<.<<....<<<<<<.<<<<..............>>>>.>>>>>>.....<<<<<....................>>>>>....<<<<<.<<.......<<...<.......>..<<<<...>>>>....>>......>>.>>..>>>.........<<...<<<<<<<<.....)))).]].>>>>>>>>..>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>.>.>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..))))..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<.......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>>....>.>>>>>....>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>......<....<<<<<<..........>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<.<<<<.<<<<....>>>>.>>>>.>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>........ ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[..[[[.(.(....).).....(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.(((......)))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(((((((.(.(((....))).).)))).)))....(.((..(...........)..))......)..((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((................))).)))))).....(((((....................)))))....(((((.((.......((..((.......)).(((.....)))....))......)).))..)))........((....(.((.(((.....]].].]].))).)).)...)..)..))...(((.(((.((...((((..((..((((((.(...((........))......).))))))..)).......((....))...))))..)).)))..))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].].((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.((....(.((((((.(..(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..))))).)..))).))).....)..)))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....((((((((.......))))))))......))...)))))))))).)...(.(..((.(..((((.((..(.(((((((..(((..(.((..(...((((((..((((.((((....)))).))))..))))))...)..)).)..)))..))))))))..)).))))...).))...)..)..(((((((((....)))))))))>....... Yeast 80S ribosome in complex with Map1 (conformation 1); 18S rRNA 8bqd BQ 3299 3.9 RF02543 URS00026813B8_4932 37079644 0003735 0005840 4932 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........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<<.<<<<<<<<<<<<<<<<<<<<.....<<<<......>>>>.(.......<<<......)>>>....>>>>>>>>>..>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<.........................<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>...>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<....<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>...>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<....<<.<<<<<<<.....<<<....<<<..<.<<<<...<<<<<<.....>>>>>>.>>>>.>..>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>..>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><<<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>.>>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<<....>>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<...............>>>>><<.<<<<<<<<<<<..<<<<<......<..<<......<...<<<<.<.<..<<<..<<<<..<<<<<<<....>>>>>>>..>>>>..>>>..>.>.>>>.>...>......>>...>....>>>>>.......>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.....<<....<<<<<....>>>>.>...>>..>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<<<<<<<<......>>>>>>.>>>>>>>>>>...<<<<<.....<<<<..<<<<........>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<.<..<<<<........>>>>..>>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((...(((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))).)...)))..))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.(((((.......(..............)..(((((((((((((((((((((((......(((((((......(((((((..))))))).......))))))).....))))).))))))))))........(((....)))....)))))))).....))))).))))).<((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.....((((((.....(((((((((..((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))....))))))))).(.((.......))...)..)))))).......))).((((((....(.(((....))).)((((((((((....((.(((((((.....(((....(((..(.((((...((((((.....)))))).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((.(((...((.........))...))).....(...(........).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))((((((((((.((......((((.((((....))))))))...)))))))))).)).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........((((.((.....).).))))....))....))...(((((........)))))]]((((..(((.(((...((((....)))...(.[[((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....)))...))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.((((((((((..(((((.((....(.((............((...((..((((.((((.(((..(((....)))..))).)))).))))..))...)).............))..)..)).))))).......))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.((((((((..((.((((((((((((((..)..)))))).))))))).))....((((.....((((..((((........))))..........]]...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((.(((((....{..)))).)))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....))))))))......(((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).)))))).)(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(((.((..)..).)))..)))))...)))....)))).)))))).))))).. Yeast 80S ribosome in complex with Map1 (conformation 1); 25S rRNA 8bqd BR 121 3.9 RF00001 URS000055688D_4932 37079644 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<....<<<.<<..............>>....>>...>>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Yeast 80S ribosome in complex with Map1 (conformation 1); 5S rRNA 8bqd BS 158 3.9 RF00002 URS00001BF64E_4932 37079644 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Yeast 80S ribosome in complex with Map1 (conformation 1); 5.8S rRNA 8bqx 2 1771 3.8 RF01960,RF02542,RF01959,RF00177 URS0001A16A88_4932 37079644 0003735 0005840 4932 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...<<<<<...((((>>>>><<<<.<<<<<<...<.<...<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<..<<..<<....<<<..................<<....<<.<<<.....>>>.>>.....>>.........<<<<<..<<....>>..>>>>><.<.<<<<<<......[[.((((.<<<....>>>....<<......>>>>>>>>.>...>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>..>>>..>....>.>.....<<<<<<<.<<<<<....>>>>>.>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>>.........<<<{{.....<.<<...<<<.<<....<<<<<<.<<<<..............>>>>.>>>>>>.....<<<<<....................>>>>>....<<<<<.<<.......<<...<.......>..<<<<...>>>>....>>......>>.>>..>>>.........<<...<<<<<<<<.....)))).]].>>>>>>>>..>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>.>.>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..))))..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<.......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>>....>.>>>>>....>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>......<....<<<<<<..........>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<.<<<<.<<<<....>>>>.>>>>.>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>........ ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[..[[[.(.(....).).....(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.(((......)))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(((((((.(.(((....))).).)))).)))....(.((..(...........)..))......)..((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((................))).)))))).....(((((....................)))))....(((((.((.......((..((.......)).(((.....)))....))......)).))..)))........((....(.((.(((.....]].].]].))).)).)...)..)..))...(((.(((.((...((((..((..((((((.(...((........))......).))))))..)).......((....))...))))..)).)))..))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].].((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.((....(.((((((.(..(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..))))).)..))).))).....)..)))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....((((((((.......))))))))......))...)))))))))).)...(.(..((.(..((((.((..(.(((((((..(((..(.((..(...((((((..((((.((((....)))).))))..))))))...)..)).)..)))..))))))))..)).))))...).))...)..)..(((((((((....)))))))))>....... Yeast 80S ribosome in complex with Map1 (conformation 2); 18S rRNA 8bqx BQ 3301 3.8 RF02543 URS00026813C4_4932 37079644 0003735 0005840 4932 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaugguguuuuguauuucacuggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguagugagagccuuggucagacgcagcgggcgugcuuguggacugcuugguggggcuugcucugcuaggcggacuacuugcgugccuuguuguagacggccuuggucuugcuacaauuaacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauagagggcuaccuuuauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<<.<<<<<<<<<<<<<<<<<<<<.....<<<<......>>>>.(.......<<<......)>>>....>>>>>>>>>..>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<.........................<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<....<<.<<<<<<<.....<<<....<<<..<.<<<<...<<<<<<.....>>>>>>.>>>>.>..>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>..>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><<<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>.>>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<<....>>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<...............>>>>><<.<<<<<<<<<...<<<<<<.<....<.<<<.....<.....<<<<<<<..<<<<.<<<<..<<<<<<<....>>>>>>>..>>>>.>>>>..>>>>>>>......>.....>>>..>..>.>>>>>>........>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.....<<....<<<<<....>>>>.>...>>..>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<<<<<<<<......>>>>>>.>>>>>>>>>>...<<<<<.....<<<<..<<<<........>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<.<..<<<<........>>>>..>>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((...(((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))).)...)))..))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.(((((.......(..............)..(((((((((((((((((((((((.......(((((((......(((((((..))))))).......))))))).....))))).))))))))))........(((....)))....)))))))).....))))).))))).<((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))....))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((((((((((....((.(((((((.....(((....(((..(.((((...((((((.....)))))).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((.(((...((.........))...))).....(...(........).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))((((((((((.((......((((.((((....))))))))...)))))))))).)).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........((((.((.....).).))))....))....))...(((((........)))))]]((((..(((.(((...((((....)))...(.[[((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....)))...))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((.....((((..((....(.((............((..(((..((.(.(.((.(.(..(.(....).)..).).)).).).))..)))..)).............))..)..))..))))..........)..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.((((((((..((.((((((((((((((..)..)))))).))))))).))....((((.....((((..((((........))))..........]]...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((.(((((....{..)))).)))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....))))))))......(((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).)))))).)(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(((.((..)..).)))..)))))...)))....)))).)))))).))))).. Yeast 80S ribosome in complex with Map1 (conformation 2); 25S rRNA 8bqx BR 121 3.8 RF00001 URS000055688D_4932 37079644 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<....<<<.<<..............>>....>>...>>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Yeast 80S ribosome in complex with Map1 (conformation 2); 5S rRNA 8bqx BS 158 3.8 RF00002 URS00001BF64E_4932 37079644 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Yeast 80S ribosome in complex with Map1 (conformation 2); 5.8S rRNA 8br8 LD 142 3.35 RF00002 URS000268138A_184922 36912103 0003735 0005840 184922 gcacgccccgccggcggaugccucggcccgggcggcgacgaagagcgcggcggagcgcgagacgcggugcggacccgcccgccccgagaagcaccgauccucgaacgcagcgcgccccggcgccgccgccucggcgccugcc ..........................................<<<<<<<((....>>>>.....<<<<<<...<..))..>.........>>>>>>...>>>....<<...>><<<..>>>..................... ..........................................((((((.[[.....))).....((((((...(..]]..).........))))))...)))....((...))((....))..................... Giardia ribosome in POST-T state (A1); 5.8S rRNA 8br8 LE 117 3.35 RF00001 URS00026813A5_184922 36912103 0003735 0005840 184922 aguucggccauccuacggcggaaacuccuuaacucguuccgaauuaggaagagaagcgccgucaggccccgccaguacugcgaucggagacgucgugggaacacggggugccgaacu <<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<<<<......<<<<<<.<<....>>>>>>>>.....>>>>>>>>>>>>>> ((((((((....((((((((.....(((.((...(.....)...)).)..))....)))))).))((((((......((((((.((....)))))))).....)))))))))))))) Giardia ribosome in POST-T state (A1); 5S rRNA 8br8 Lt 2593 3.35 RF02543 URS0002681395_184922 36912103 0003735 0005840 184922 ggcgggccugaggcggcgggggcgacgggcggaacuuaagcauaucaguacgccccggaggagaaaccaaccgggauuccccgcuagcggcgagcgacgcgggaggagcccgccccgaaggcgcgcuguggggccgcgagggggcccgagggccccgcccgagagggugcaagccccguacggcgaguagcgcugcuugagcgugcagcgcgaagggaggcgcggcccuuccaaggcuaaauacgccccgggaccgauagcggaccaaguagcgcgagcgaacggugaaaaggacgcccugcggccgcucaaaagaccugaacccggccggccgccggcccgccggccccgucucgaaacacggaccgaggagccacgcgccgcggcgagcccgagggagcccccgcggcggagcgagcgcgagacgccccgggcccgccaugccccugcgggcgugcgcgggccgagccgcggcgcgugggcccgaaaggcggugaucuaugcccggcgagggcgaggccgggcgaaagccugguggaggcccgccgcggugcugacgcgcagaucgcucgucggagccgggcaugggggcgaaagacucaucgaaccgccugguagcugguugccuccgaaaugucucccaggacagccgccgccccgcaguugcggcccguagagcgcuggccggcgggagcggggggccugccccucgcccgccccccaaacuccgaagggccgcgccgccccgccgcuggccugggcggggcgggcgaaugcgggcggcgcgugggccccuccugguaagcaggacgggcgaggcgggacgauccggacgccgggccagggugcgccgccggggcccgcggaacggcgucggccggucccgacagccgaaucggccggcccggaaaauggagcgcgccggagccccggacccgcgcccggccgccgcgcgcggcggguaggaggccgcagaggccccgggggcgaaggcggcgcgcaggccccgccggaccggccucuggugcagaucucggcagcaguagccgcuacuccgcgccccggaggacugagggggagacggguuccgcggcgccugcaucuggccgcgggugacucgggccuaagcggcgggugaagaccgggaaggggcgcccgcccgucgaacggggagccggcggagacuccggcaggcgcggcccccgcggagacgcccgccccccggcgacgcgcacggggaccgcggcgggcggcgccccggcccgcgaacgccccgcagcccccggacgccuugcgcggagaggggggcccgggggcggaccgcgcguccccggccgccccugaaaagccggggggcgccggccgcgcgccguaccgaccgcagcaggacuccggggucagcagccucuagcgcgggagcgaacgcggcucagggaagucggcaagccggcuccguaaccucgggaaaaggaguggcucugacggcgccgggucagaacuggaacggacgcggggaucccgacuguuuacuagaaacacagcgucgcgagggccgcacccggcgcuggcgcgacgugauuucugcccagugccacgaccgucaccgugaagcgauccgccgaagcccugguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucgggcaauuuccgacgugcaugaauggaccaacgaggaucccacugucccgagccgcgccuccgcgagccuccagccucgggaacgggcgagggccggccagcggggcaagaagacccuuuugagcuugacuccagcccgggccuguggggcggggcggccggcgcagcgcacaggggaggccgcgccccugagacacccugacggccgccgccgccccgcucacccggucgcgcggggacccgcccgggcggggaguucggcuggggcggcgcgccugcuacaccggaccgcaggcgucccacggcgggcucagcgaggacggagaccucccgcggagcagaagggcacaagcccgcccgacccgcgccccccgugccggcgcgggccgcgaaagcggggccuaccgauccuucgccgccccggccgcgggcgcggagguggcagaaaaguuaccacagggauaacuggcuuguggccgccgagcgcccgcagcgacgcggcuuuuugauccuucgaugucggcucuuccuaccguccgcgcgcaccggcgcggaagcgucggauuguucacccguucaagggaucgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacuggccccggggccagagcacggcgggccaguacgagaggaacgcccgccgcgggccgccagccccgcgguugcccggccgggcagcgccgcgccgccgcgcccgggggcccugcgcugaccgccucuaagcgcgcaccccgccucgcgccccgcccggccgcgcgccccagccccgugccccgucgccgagcggcccccgcccggggagaccacccggcgcggcgcuccuguacggcgcagagcccugcgaucgccugagggacgcgccugcagagcgcgg .........................<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<.....<<.....>>.....>>>>>..[[[...<<<<...........>>>><<<<....<<<<<......>>>>>((......<<<.....))>>>...>>>>.....<<<<<<<........>>>>>>>...(((((..<<<<<<)))))..]]]..................................<<....>>................<<<....>>>............................<<<<<<..>>>>>>.<<<<........>>>>.<<<<<....<<<<<<<<<<<<<..<<<...<<<....>>>..>>>...<<....>>............<<<<<<<<<<<<<....>>>>>>>.>>>>>>...>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<<.<<<.<<<<<<<<<...<<<...<<<..<<<<<<..<<<<<<......>>>>>>>>>>>>..>>>..>>.>...>>>>>>>.<<<<<<<<<<.........>>>>>>>>>>...>>>>>>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((...<<<<<<<........<<<.<<<<<<<<<..............>>>>>>>>>>>>..........)))......>>>>>>>>>>>..>>>>>>><<<<<....>>>>>....>>>>>>..<<<<<<<<...<<......<<<<<.<<....>>.>>>>>...>>>>>>>>>>........>>>>>.<<.....<<.....<<<<<.....>>>>>..<<.....<<<<..<<...<<<<<<...<.......>.>>>>>>....((<<<.<<...<<<...<<<....>>>......<<....>>...>>.>....>>...<<<<<........>>>>>))<<<<<<<<...<<<....>>>..<<<<<<<<<<...<<<..<<<<<<<<<<<<<<<<<...{{{...>>>>>....<<<<<<...<<<<<<...<<<.....>>>.....>>>>>>...>>>>>>..>>>>>.>>>>>>>..>>>.........>>>>>>>>>>...>>>>>>>>.>>>..>>..<<......>>.>>>>.<<<<.....>>>>..>>....<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<....>>..>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<....>>>>......>>>>>>>...<<..<<<..<<<<<<.<...<<....<<<.<....>.>>>....>>.>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>....>>.(..<<<<<......).>>>>>...((((((..{{{.........{{{..{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<<<<<<<<<..........<<<<<....................>>>>>.>>>>>>>>.>>>>>>>>>...<<<<......>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<.<<<<.......>>>>.>.....<<...(((>>....>>>>>>>...<<<<<<<<.........>>>>>>>>.<<<....>>>.>>)))......((((((.(((((.>>>>>>))))))))))).........]]]]..}}.}}}.......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<.<.....>.>>>....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........}}}.))))))..<<<<<..<<<..<<<<<<<<...............>>>>>>>><<<<<...<.<<...<<<<<<<<<<}}}.>>>>>..>>>>>...>>.>.>>>>>.<<<...<<<<<<...........>>>>>>...>>>..>>>..>>>>><...<<<<<<............................>>>>>>..><<.<<<<.......>>>>..<<<<<<<<<<<....<<<<....<<...>>...>>>>...>>>>.>>>>>.>>.....>>.. .........................((((((.....(...[..)......))))).).........((....))...((((.....((.]...)).....))))...((((..(((...(...).....)))(((......((((......)))).[[(...).(((.....]])))....))))....(((((((........)))))))...(((((..[[[[[[)))))..)))..................................((....))............(...(((....)))...........)................((((((..))))))[((((........)))).(((((....(((((((((((((..((....(((....)))...))...((....))....(......)(((((((((((((....))))))).))))))...)))))))))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(((((....)))))((((((((((.(((.(((((((((...(((...(((..((((((...((((........)))).))))))..)))..)).)...))))))).((((((((((.........))))))))))...))))))))))))).))..((((..((((.....))))..))))....(((......)))...(((((((...((([[[...(((((((........(((.(.((((((((............)))))))).))))..........]]]......))))))))))...)))))))(((((....)))))....))))))(.((((((((...((......(((((.((....)).)))))...))))))))))..).....))))).((.....((.....(((((.....)))))..((.....((((..((..(((((((...(.......).))))))....[[(((.((...(((...(((....))).(....((....)).).)).)....))...(((((........)))))]]((((((((...(((....)))...(((((((((...(((..(((((((((((((((((.(.{{{)..)))))....((((((...((((((....((.....))......))))))...))))))..))))).)))))))..)))(...)....)))))))))....)))))))).))).)))..((......)).)))).((((.....))))..))....((((....((((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((....)..)))))).))(...).......(((((((((.].((.........))...(((((((....(((......)))......))))))).}.(((.(((..((((((.(...((....(((.(....).)))....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)).{..(((((.....]}.)))))...((((((..(((.((......(((..((((((..(((((.((((((((..((((((((((((.((((..........((((......................)))).)))).))).)))))))))...((((......)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.(.((((.......)))).)...).((][.[[[))....)))))))...((((((((.....{...)))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....)}....))))..)).))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(((((((((......))))))..))).(((.(.....).)))....)))))..)...))).).....(((((((....))).))))..>.))..))).))))))..(((((..(((..((((((((.....(....)....))))))))(((((...(.((...((((((((((}}}.)))))..)))))...)).).))))).(((....((((.............))))....)))..)))..)))))....((((((........(..)................))))))...((.((((.......))))..(((((((((((....((((.(..((...))..)))))...)))).))))).)).....)).. Giardia ribosome in POST-T state (A1); Large Subunit rRNA 8br8 Lu 57 3.35 URS0000326EAC_184922 36912103 0030533 0006412 184922 agcagaguggcgcagcggaagcguaggucgauggaucgaaaccauccucugcuacca <<<<<<<..<<<<.......>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((....[..)))).....(((((..]....)))))))))))).... Giardia ribosome in POST-T state (A1); E-site tRNA 8br8 St 1454 3.35 RF01960,RF02542,RF01959,RF00177 URS00026813B3_184922 36912103 0003735 0005840 184922 cauccggucgauccugccggagcgcgacgcucuccccaaggacgaagccaugcaugcccgcucacccgggacgcggcggacggcucaggacaacgguugcaccccccgcggcggucccugcuagccggacaccgcuggcaacccggcgccaagacgugcgcgcacgggcgcgcgccccgcgggcgagcagcgugacgcagcgacggcccgcccgggcuuccggggcaucacccggucggcgcggucgcggcgcgccgagggcccgacgccuggcggagaaucaggguucgacuccggagagcgggccugcgagacggcccgcacauccaaggacggcagcaggcgcggaacuugcccaaugcgcggcgcgcgaggcagcgacggggagcgcgcgagcgaggcgggcccacagcccccgccgcgcagccgagggcaaggucugugccagcagccgcgguaauuccagcucggcgagcgucgcgcggcgcugcugcaguugaaacgcccguaguuggccccccgccgccacgaggaaacgggagcgcuccaggcaggcccguuggccccgccgcgugggaccgcgcagcgggcgcggcgcgccgccgccgcagccccgaggagagcgggcgggggcaccgguaccggccggggacgggugaaacaggaugaucccgccgagaccgccggccgcgcaggcgccugccaagaccgccucugucaaucaagggcgaaggccgggggcuagaaggcgaucagacaccaccguauucccggccguaaacggugccgccccgcggccggcgcgcgcgucccgccggccgcccagggaaaccgggaggcuccgggcucuggggggaguauggccgcaaggcugaaacuugaaggcauugacggagggguaccaccagacguggagucugcggcucaaucugacucaacgcgcgcaccucaccaggcccggacgcgcggaggaccgacagccgggcgcgcuuucgcgaucgcgcgggugguggugcauggccgcucccagcccguggcgcgagccgucugcuccauugcgacaacgagcgagaccccggccgcgggcgccgcgggacggcccgcggcagcgggaggacggcggggcgauagcaggucugugaugcccucagacgcccugggccgcacgcgcgcuacacuggcggggccagccggcgcccgccaggacgcgcggagcccccgccguggccgggaccgcgggcuggaacgcccccgcgcaccaggaaugucuuguaggcgcccgcccccaccgcgcgccggacgcgucccugccccuuguacacaccgcccgucgcuccuaccgacugggcgcggcggcgagcgccccggacgcgcgaagggccgcgagcccccgcgccuggaggaaggagaagucguaacaagguauccguaggugaaccugcggauggauccuu ...<<<<<.[..(((>>>>>.<<<<<<<<<..<<<<<..<......<<<.<<<..<<<.<<...........>>>>>......<<........<<<..<<..<<...<<<<<.............<<.....<<<<<<....>>>>>>......>>........<.<.<<<<...[.[...<.....>..>>>>.>>........>.>>>>..>>>>..>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>...<<<<<<<<....>>>>...>>>>.>>.<<<<<<..........>>>>>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>>>>............<<<<<<.........>>>>>>.....<<<<<<<......[..[.....((..>>)).......]..].>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.......<<<.<<<<<<.......<<..<<.......>>...........>>......>>>>>..>.>>>..<<<<<<.....].]..>>>..>>>..........<<<<<<<.....<<<<..<<..<<<<<.<<<..<.<......>.>.....>>>.>>>>.>.>>.......<<....>>...>>>>....>>>>.>>>...>>>...>>>>...<<<<<<<<...<...<<.<.........>.>>...>>>>>>>>>.........<<<.<<..<<<<<<<<<<.<.....>.>>>>>>>>>>...<<..))>>....>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..)))..]<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>.........<<<<<......<<<<<<......<<<.<<<.......>>>.>>>....>>>>>>...<<.<<<..<<.<<<<<<....<<.<<<<<<....>>>....<<......>>....>>>.>>....<<<<..<<<<<<...>>>>>>.....<<<<<....>>>>>........>>>>....>>>.>>>.....>>>>>>>.......>>>>>...>>.>>>>.>>>.....<<<<<<<.......<<<.<<....>>.>>>.......>>>>>>>...........<<.<<<<......>>>>.>>..........>>>>>>....<<<<<.<<.......>>.>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<<.<<....<<<<<<<<.<<<..<<<.<<<...........>>>.>>>..>>>.>>>>>>>>...>>.>>>>>..>.>>...>.....<<<<<<<<<<..>>>>>>>>>>........ ...((((..[..[[..)))).(((((((((..(((((..((.....(((.(((..(((.((...........)))))......(((.......(((..((..((...((((..........(...((.....((((((....))))))......))...(....(...((((...{.....(.....)..))))..)...).)....))))..))))..))).(((....(((..((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((((((..........)))))).(.((....)).)...)))))).).....(.(((...((((.....))).))))).)...)))))...(..).....((((((.........)))))).....((((([[......(..(.....((..]])).......)..).)))))..)))))))))...[......((([[...(.((((...(((.......(((.((((((.......((..((.......))...........))......)))))..).)))...(((((.......}..))).).)..........((((((((.(...((((..((...((((.((...(..........)......)).))))...)).......((....))...))))..).)))).)))..))))...))))....((((((....(...((.(.........).))...).))))))......{...(((.((..((((((((((.(.....).))))))))))...((..]]))....))...].))))))).(((......((((....))))....)))...]]..](((((.(((((((..((..(((((..(((..(((((.......(........)..........(((((.(....(((((.......(((.(((.......))).))).....)))))...((.(((...(.((((((....((.((((((....)))..(.((......)))...))).))....((((..((((((...))))))..(..(((((....))))).....)..))))....))).))).....).))))).....).)))))...)).)))..))).(...(((((((.....(.(((.((....)).)))...)...)))))))......(....((.((((......)))).))....)..)..))))).....(((((.((.......)).)))))......))...)))))))))).))....(..((.(..((((.((..(.((((((((.(((..(((.(((...........))).)))..))).)))))))))..)).))))...).))...).....(((((((((....)))))))))}....... Giardia ribosome in POST-T state (A1); Small Subunit rRNA 8brm LD 142 3.33 RF00002 URS000268139E_184922 36912103 0003735 0005840 184922 gcacgccccgccggcggaugccucggcccgggcggcgacgaagagcgcggcggagcgcgagacgcggugcggacccgcccgccccgagaagcaccgauccucgaacgcagcgcgccccggcgccgccgccucggcgccugcc ..........................................<<<<<<.((.....>>>.....<<<<<<...<..))..>.........>>>>>>...>>>....<<...>><<<..>>>..................... ..........................................((((((.[[.....))).....((((((...(..]]..).........))))))...)))....((...))((....))..................... Giardia ribosome in POST-T state, no E-site tRNA (A6); 5.8S rRNA 8brm LE 117 3.33 RF00001 URS00026813A5_184922 36912103 0003735 0005840 184922 aguucggccauccuacggcggaaacuccuuaacucguuccgaauuaggaagagaagcgccgucaggccccgccaguacugcgaucggagacgucgugggaacacggggugccgaacu <<<<<<<<....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>><<<<<<......<<<<<<.<<....>>>>>>>>.....>>>>>>>>>>>>>> ((((((((....((((((((.....(((.((...(.....)...)).)..))....)))))).))((((((......((((((.((....)))))))).....)))))))))))))) Giardia ribosome in POST-T state, no E-site tRNA (A6); 5S rRNA 8brm Lt 2594 3.33 RF02543 URS0002681395_184922 36912103 0003735 0005840 184922 ggcgggccugaggcggcgggggcgacgggcggaacuuaagcauaucaguacgccccggaggagaaaccaaccgggauuccccgcuagcggcgagcgacgcgggaggagcccgccccgaaggcgcgcuguggggccgcgagggggcccgagggccccgcccgagagggugcaagccccguacggcgaguagcgcugcuugagcgugcagcgcgaagggaggcgcggcccuuccaaggcuaaauacgccccgggaccgauagcggaccaaguagcgcgagcgaacggugaaaaggacgcccugcggccgcucaaaagaccugaacccggccggccgccggcccgccggccccgucucgaaacacggaccgaggagccacgcgccgcggcgagcccgagggagcccccgcggcggagcgagcgcgagacgccccgggcccgccaugccccugcgggcgugcgcgggccgagccgcggcgcgugggcccgaaaggcggugaucuaugcccggcgagggcgaggccgggcgaaagccugguggaggcccgccgcggugcugacgcgcagaucgcucgucggagccgggcaugggggcgaaagacucaucgaaccgccugguagcugguugccuccgaaaugucucccaggacagccgccgccccgcaguugcggcccguagagcgcuggccggcgggagcggggggccugccccucgcccgccccccaaacuccgaagggccgcgccgccccgccgcuggccugggcggggcgggcgaaugcgggcggcgcgugggccccuccugguaagcaggacgggcgaggcgggacgauccggacgccgggccagggugcgccgccggggcccgcggaacggcgucggccggucccgacagccgaaucggccggcccggaaaauggagcgcgccggagccccggacccgcgcccggccgccgcgcgcggcggguaggaggccgcagaggccccgggggcgaaggcggcgcgcaggccccgccggaccggccucuggugcagaucucggcagcaguagccgcuacuccgcgccccggaggacugagggggagacggguuccgcggcgccugcaucuggccgcgggugacucgggccuaagcggcgggugaagaccgggaaggggcgugcccgcccgucgaacggggagccggcggagacuccggcaggcgcggcccccgcggagacgcccgccccccggcgacgcgcacggggaccgcggcgggcggcgccccggcccgcgaacgccccgcagcccccggacgccuugcgcggagaggggggcccgggggcggaccgcgcguccccggccgccccugaaaagccggggggcgccggccgcgcgccguaccgaccgcagcaggacuccggggucagcagccucuagcgcgggagcgaacgcggcucagggaagucggcaagccggcuccguaaccucgggaaaaggaguggcucugacggcccgggucagaacuggaacggacgcggggaucccgacuguuuacuagaaacacagcgucgcgagggccgcacccggcgcuggcgcgacgugauuucugcccagugccacgaccgucaccgugaagcgauccgccgaagcccugguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucgggcaauuuccgacgugcaugaauggaccaacgaggaucccacugucccgagccgcgccuccgcgagccuccagccucgggaacgggcgagggccggccagcggggcaagaagacccuuuugagcuugacuccagcccgggccuguggggcggggcggccggcgcagcgcacaggggaggccgcgccccugagacacccugacggccgccgccgccccgcucacccggucgcgcggggacccgcccgggcggggaguucggcuggggcggcgcgccugcuacaccggaccgcaggcgucccacggcgggcucagcgaggacggagaccucccgcggagcagaagggcacaagcccgcccgacccgcgccccccgugccggcgcgggccgcgaaagcggggccuaccgauccuucgccgccccggccgcgggcgcggagguggcagaaaaguuaccacagggauaacuggcuuguggccgccgagcgcccgcagcgacgcggcuuuuugauccuucgaugucggcucuuccuaccguccgcgcgcaccggcgcggaagcgucggauuguucacccguucaagggaucgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacuggccccggggccagagcacggcgggccaguacgagaggaacgcccgccgcgggccgccagccccgcgguugcccggccgggcagcgccgcgccgccgcgcccgggggcccugcgcugaccgccucuaagcgcgcaccccgccucgcgccccgcccggccgcgcgccccagccccgugccccgucgccgagcggcccccgcccggggagaccacccggcgcggcgcuccuguacggcgcagagcccugcgaucgccugagggacgcgccugcagagcgcgg .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<.....<<.....>>.....>>>>>..[[[...<<<.............>>><<<<....<<<<<......>>>>>((......<<<.....))>>>...>>>>.....<<<<<<<........>>>>>>>...(((((..<<<<<<)))))..]]]..................................<<....>>................<<<....>>>............................<<<<<<..>>>>>>.<<<<........>>>>.<<<<<....<<<<<<<<<<<<<..<<<...<<<....>>>..>>>...<<....>>............<<<<<<<<<<<<<....>>>>>>>.>>>>>>...>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<<.<<<.<<<<<<<<<...<<<...<<...<<<<<<...<<<<........>>>>.>>>>>>...>>..>>.>...>>>>>>>.<<<<<<<<<<.........>>>>>>>>>>...>>>>>>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((...<<<<<<<........<<<.<<<<<<<<<..............>>>>>>>>>>>>..........)))......>>>>>>>>>>>..>>>>>>><<<<<....>>>>>....>>>>>><.<<<<<<<<...<<......<<<<<.<<....>>.>>>>>...>>>>>>>>>>..>.....>>>>>.<<.....<<.....<<<<<.....>>>>>..<<.....<<<<..<<...<<<<<<...<.......>.>>>>>>....((<<<.<<...<<<...<<<....>>>......<<<<..>>>>...>>.>....>>...<<<<<........>>>>>))<<<<<<<<...<<<....>>>..<<<<<<<<<<...<<<..<<<<<<<<<<<<<<<<<...{{{...>>>>>....<<<<<<...<<<<<<....<<.....>>......>>>>>>...>>>>>>..>>>>>.>>>>>>>..>>>.........>>>>>>>>>>...>>>>>>>>.>>>..>>..<<......>>.>>>>.<<<<.....>>>>..>>....<<<<....<<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<.<<<<<<<<.>>>..>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<....>>>>......>>>>>>>...<<..<<<..<<<<<<.<...<<....<<<.<....>.>>>....>>.>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>....>>....<<<<<........>>>>>...((((((..{{{.........{{{..{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<.<<<..<<...........................................>>..>>>..>>>>>>>>...<<<<......>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<.<<<<.......>>>>.>.....<<...(((>>....>>>>>>>...<<<<<<<<.........>>>>>>>>.<<<....>>>.>>)))......((((((.(((((.>>>>>>))))))))))).........]]]]..}}.}}}.......<<.<...<<<<<<<..<<.......>>>..>>>>>>....>.>.>.......<.<<<..<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<.........>>>....>>>>>......>>>..>....<<<<<<<....>>>.>>>>........}}}.))))))..<<<<<..<<<..<<<<<<<<...............>>>>>>>><<<<<...<.<<...<<<<<<<<<<}}}.>>>>>..>>>>>...>>.>.>>>>>.<<<...<<<<<<...........>>>>>>...>>>..>>>..>>>>>....<<<<<<............................>>>>>>...<<.<<<<.......>>>>..<<<<<<<<<<<....<<<<....<<...>>...>>>>...>>>>.>>>>>.>>.....>>.. .........................((((((.....(...[..)......))))).).........((....))...((((.....((.]...)).....))))...((((..(((...(...).....)))(((......((((......)))).[[(...).(((.....]])))....))))....(((((((........)))))))...(((((..[[[[[[)))))..)))..................................((....))............(...(((....)))...........)................((((((..))))))[((((........)))).(((((..(.(((((((((((((..((....(((....)))...))...((....))....(......)(((((((((((((....))))))).))))))...)))))))))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))).((((((....(((((....)))))((((((((((.(((.(((((((((...(((...(((..((((((...((((........)))).))))))..)))..)).)...))))))).((((((((((.........))))))))))...))))))))))))).))..((((.((((.......)))).))))....(((......)))...(((((((...((([[[...(((((((........(((.(.((((((((............)))))))).))))..........]]]......))))))))))...)))))))(((((....)))))....))))))(.((((((((...((......(((((.((....)).)))))...))))))))))..).....))))).((.....((.....(((((.....)))))..((.....((((..((..(((((((...(.......).))))))....[[(((.((....((...(((....))).(....((((..)))).).))......))...(((((........)))))]]((((((((...(((....)))...(((((((((...(((..(((((((((((((((((...{{{...)))))....((((((...((((((....((.....))......))))))...))))))..))))).)))))))..)))(...)....)))))))))....)))))))).))).)))..((......)).)))).((((.....))))..))....((((....((((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((.))..)))))).))(...).......(((((((((.].((.........))...(((((((....(((......)))......))))))).}.(((.(((..((((((.(...((....(((.(....).)))....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)).{..(((((.....]}.)))))...((((((..(((.((......(((..((((((..(((((.((((((((..((((((((..((..((...............(.....................).....))..))...))))))))...((((......)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.(.((((.......)))).)...).((][.[[[))....)))))))...((((((((.....{...)))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....)}....))))..)).))).......((.(...((((((...((.......))...))))))....).).)........((((.((((((..(((((((((......))))))..))).(((.(.....).)))....)))))..)...))).).....(((((((....))).))))..>.))..))).))))))..(((((..(((..((((((((.....(....)....))))))))(((((...(.((...((((((((((}}}.)))))..)))))...)).).))))).(((....((((.............))))....)))..)))..)))))....((((((........(..)................))))))...((.((((.......))))..(((((((((((....((((.(..((...))..)))))...)))).))))).)).....)).. Giardia ribosome in POST-T state, no E-site tRNA (A6); Large Subunit rRNA 8brm St 1454 3.33 RF01960,RF02542,RF01959,RF00177 URS00026813B3_184922 36912103 0003735 0005840 184922 cauccggucgauccugccggagcgcgacgcucuccccaaggacgaagccaugcaugcccgcucacccgggacgcggcggacggcucaggacaacgguugcaccccccgcggcggucccugcuagccggacaccgcuggcaacccggcgccaagacgugcgcgcacgggcgcgcgccccgcgggcgagcagcgugacgcagcgacggcccgcccgggcuuccggggcaucacccggucggcgcggucgcggcgcgccgagggcccgacgccuggcggagaaucaggguucgacuccggagagcgggccugcgagacggcccgcacauccaaggacggcagcaggcgcggaacuugcccaaugcgcggcgcgcgaggcagcgacggggagcgcgcgagcgaggcgggcccacagcccccgccgcgcagccgagggcaaggucugugccagcagccgcgguaauuccagcucggcgagcgucgcgcggcgcugcugcaguugaaacgcccguaguuggccccccgccgccacgaggaaacgggagcgcuccaggcaggcccguuggccccgccgcgugggaccgcgcagcgggcgcggcgcgccgccgccgcagccccgaggagagcgggcgggggcaccgguaccggccggggacgggugaaacaggaugaucccgccgagaccgccggccgcgcaggcgccugccaagaccgccucugucaaucaagggcgaaggccgggggcuagaaggcgaucagacaccaccguauucccggccguaaacggugccgccccgcggccggcgcgcgcgucccgccggccgcccagggaaaccgggaggcuccgggcucuggggggaguauggccgcaaggcugaaacuugaaggcauugacggagggguaccaccagacguggagucugcggcucaaucugacucaacgcgcgcaccucaccaggcccggacgcgcggaggaccgacagccgggcgcgcuuucgcgaucgcgcgggugguggugcauggccgcucccagcccguggcgcgagccgucugcuccauugcgacaacgagcgagaccccggccgcgggcgccgcgggacggcccgcggcagcgggaggacggcggggcgauagcaggucugugaugcccucagacgcccugggccgcacgcgcgcuacacuggcggggccagccggcgcccgccaggacgcgcggagcccccgccguggccgggaccgcgggcuggaacgcccccgcgcaccaggaaugucuuguaggcgcccgcccccaccgcgcgccggacgcgucccugccccuuguacacaccgcccgucgcuccuaccgacugggcgcggcggcgagcgccccggacgcgcgaagggccgcgagcccccgcgccuggaggaaggagaagucguaacaagguauccguaggugaaccugcggauggauccuu ...<<<<<.[..(((>>>>>.<<<<<<<<<..<<<<<.........<<<.<<<..<<<.<<...........>>>>>......<<........<<<..<<..<<...<<<<<.............<<.....<<<<<<....>>>>>>......>>........<.<.<<<<...[.[...<.....>..>>>>.>>........>.>>>>..>>>>..>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>...<<<<<<<<....>>>>...>>>>.>>.<<<<<<..........>>>>>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>......>>>>>............<<<<<<.........>>>>>>.....<<<<<<<......[........((..>>))..........].>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.......<<<.<<<<<<.......<<..<<.......>>...........>>......>>>>>..>.>>>..<<<<<<.....].]..>>>..>>>..........<<<<<<<.....<<<<..<<..<<<<<.<<<..<.<......>.>.....>>>.>>>>.>.>>......<<<....>>>..>>>>....>>>>.>>>...>>>...>>>>...<<<<<<<<...<...<<.<.<.....>.>.>>...>>>>>>>>>.........<<<.<<..<<<<<<<<<<.<.....>.>>>>>>>>>>...<<..))>>....>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..)))..]<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>.........<<<<<......<<<<<<.......<<.<<<.......>>>.>>.....>>>>>>...<<.<<<...<<<<<<<<....<<.<<<<<<....>>>....<<......>>....>>>.>>....<<<<..<<<<<<...>>>>>>.....<<<<<....>>>>>........>>>>....>>>.>>>...>.>.>>>>>.......>>>>>...>>.>>>>.>>>.....<<<<<<<.......<<<.<<....>>.>>>.......>>>>>>>......<....<<.<<<<......>>>>.>>....>.....>>>>>>....<<<<<.<<.......>>.>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<<.<<....<<<<<<<<.<<<..<<<.<<<...........>>>.>>>..>>>.>>>>>>>>...>>.>>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>........ ...((((..[..[[..)))).(((((((((..(((((...(.....(((.(((..(((.(.............))))......(((.......(((..((..((...((((..........(...((.....((((((....))))))......))............((((...{.{...(.....)..))))........)....))))..))))..))).(((....(((..((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((((((..........)))))).(.((....)).)...)))))).).....(.(((...(((((...)))).))))).....)))))...(..).....((((((.........)))))).....((((([[......(..(.....((..]])).......)..).)))))..)))))))))...[......((([[...(.((((...(((.......(((.((((((.......((..((.......))...........))......)))))..).)))..((.(((.....}.}..)))...)).........((((((((.(...((((..(((..((((.((...(..........)......)).))))..))).......((....))...))))..).)))).)))..))))...))))....((((((....(...((.(.........).))...).))))))......{...(((.((..((((((((((.(.....).))))))))))...((..]]))....))...].))))))).(((......((((....))))....)))...]]..](((((.(((((((..((..(((((..(((.(((.((......((........)).........(((((.(....(((((.....(..((.(((.......))).))....).)))))...((.(((...(.((((((....((.((((((....)))..(.((......)))...))).))....((((..(((((.....)))))..(..(((((....))))).....)..))))....))).))).....).))))).....).)))))...))..))).))).(...(((((((.....(.(((.((....)).)))...)...)))))))......(....((.((((......)))).))....)..)..))))).....(((((.((.......)).)))))......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(((.(((...........))).)))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}....... Giardia ribosome in POST-T state, no E-site tRNA (A6); Small Subunit rRNA 8bsi LD 137 3.4 RF00002 URS000268138A_5741 36912103 0003735 0005840 5741 acgccccgccggcggaugccucggcccgggcggcgacgaagagcgcggcggagcgcgagacgcggugcggacccgcccgccccgagaagcaccgauccucgaacgcagcgcgcccgcgccgccgccucggcgccugc ........................................<<<<<<.((.....>>>.....<<<<<<...<..))..>.........>>>>>>...>>>....<<...>><<..>>.................... ........................................((((((.[[.....))).....((((((...(..]]..).........))))))...)))....((...))((..)).................... Giardia ribosome chimeric hybrid-like GDP+Pi bound state (B1); 5.8S rRNA 8bsi LE 115 3.4 RF00001 URS00026813A5_5741 36912103 0003735 0005840 5741 uucggccauccuacggcggaaacuccuuaacucguuccgaauuaggaagagaagcgccgucaggccccgccaguacugcgaucggagacgucgugggaacacggggugccgaacu <<<<<<....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>><<<<<<......<<<<<<.<<....>>>>>>>>.....>>>>>>>>>>>>.. ((((((....((((((((.....((((((...(.....)...))))..))....)))))).))((((((......((((((.((....)))))))).....)))))))))))).. Giardia ribosome chimeric hybrid-like GDP+Pi bound state (B1); 5S rRNA 8bsi Lt 2593 3.4 RF02543 URS0002681395_5741 36912103 0003735 0005840 5741 ggcgggccugaggcggcgggggcgacgggcggaacuuaagcauaucaguacgccccggaggagaaaccaaccgggauuccccgcuagcggcgagcgacgcgggaggagcccgccccgaaggcgcgcuguggggccgcgagggggcccgagggccccgcccgagagggugcaagccccguacggcgaguagcgcugcuugagcgugcagcgcgaagggaggcgcggcccuuccaaggcuaaauacgccccgggaccgauagcggaccaaguagcgcgagcgaacggugaaaaggacgcccugcggccgcucaaaagaccugaacccggccggccgccggcccgccggccccgucucgaaacacggaccgaggagccacgcgccgcggcgagcccgagggagcccccgcggcggagcgagcgcgagacgccccgggcccgccaugccccugcgggcgugcgcgggccgagccgcggcgcgugggcccgaaaggcggugaucuaugcccggcgagggcgaggccgggcgaaagccugguggaggcccgccgcggugcugacgcgcagaucgcucgucggagccgggcaugggggcgaaagacucaucgaaccgccugguagcugguugccuccgaaaugucucccaggacagccgccgccccgcaguugcggcccguagagcgcuggccggcgggagcggggggccugccccucgcccgccccccaaacuccgaagggccgcgccgccccgccgcuggccugggcggggcgggcgaaugcgggcggcgcgugggccccuccugguaagcaggacgggcgaggcgggacgauccggacgccgggccagggugcgccgccggggcccgcggaacggcgucggccggucccgacagccgaaucggccggcccggaaaauggagcgcgccggagccccggacccgcgcccggccgccgcgcgcggcggguaggaggccgcagaggccccgggggcgaaggcggcgcgcaggccccgccggaccggccucuggugcagaucucggcagcaguagccgcuacuccgcgccccggaggacugagggggagacggguuccgcggcgccugcaucuggccgcgggugacucgggccuaagcggcgggugaagaccgggaaggggcgcccgcccgucgaacggggagccggcggagacuccggcaggcgcggcccccgcggagacgcccgccccccggcgacgcgcacggggaccgcggcgggcggcgccccggcccgcgaacgccccgcagcccccggacgccuugcgcggagaggggggcccgggggcggaccgcgcguccccggccgccccugaaaagccggggggcgccggccgcgcgccguaccgaccgcagcaggacuccggggucagcagccucuagcgcgggagcgaacgcggcucagggaagucggcaagccggcuccguaaccucgggaaaaggaguggcucugacggcgccgggucagaacuggaacggacgcggggaucccgacuguuuacuagaaacacagcgucgcgagggccgcacccggcgcuggcgcgacgugauuucugcccagugccacgaccgucaccgugaagcgauccgccgaagcccugguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucgggcaauuuccgacgugcaugaauggaccaacgaggaucccacugucccgagccgcgccuccgcgagccuccagccucgggaacgggcgagggccggccagcggggcaagaagacccuuuugagcuugacuccagcccgggccuguggggcggggcggccggcgcagcgcacaggggaggccgcgccccugagacacccugacggccgccgccgccccgcucacccggucgcgcggggacccgcccgggcggggaguucggcuggggcggcgcgccugcuacaccggaccgcaggcgucccacggcgggcucagcgaggacggagaccucccgcggagcagaagggcacaagcccgcccgacccgcgccccccgugccggcgcgggccgcgaaagcggggccuaccgauccuucgccgccccggccgcgggcgcggagguggcagaaaaguuaccacagggauaacuggcuuguggccgccgagcgcccgcagcgacgcggcuuuuugauccuucgaugucggcucuuccuaccguccgcgcgcaccggcgcggaagcgucggauuguucacccguucaagggaucgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacuggccccggggccagagcacggcgggccaguacgagaggaacgcccgccgcgggccgccagccccgcgguugcccggccgggcagcgccgcgccgccgcgcccgggggcccugcgcugaccgccucuaagcgcgcaccccgccucgcgccccgcccggccgcgcgccccagccccgugccccgucgccgagcggcccccgcccggggagaccacccggcgcggcgcuccuguacggcgcagagcccugcgaucgccugagggacgcgccugcagagcgcgg .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<.....<<.....>>.....>>>>>..[[[...<<<.............>>><<<<....<<<<<......>>>>>((......<<<.....))>>>...>>>>.....<<<<<<<........>>>>>>>...(((((..<<<<<<)))))..]]]..................................<<....>>................<<<....>>>............................<<<<<<..>>>>>>.<<<<........>>>>.<<<<<....<<<<<<<<<<<<<..<<<...<<<....>>>..>>>...<<....>>............<<<<<<<<<<<<<....>>>>>>>.>>>>>>...>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<<.<<<.<<<<<<<<<...<<<...<<...<<<<<<..<<<<<<......>>>>>>>>>>>>...>>..>>.>...>>>>>>>.<<<<<<<<<<.........>>>>>>>>>>...>>>>>>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((...<<<<<<<........<<<.<<<<<<<<<..............>>>>>>>>>>>>..........)))......>>>>>>>>>>>..>>>>>>><<<<<....>>>>>....>>>>>><.<<<<<<<<...<<......<<<<<.<<....>>.>>>>>...>>>>>>>>>>..>.....>>>>>.<<.....<<.....<<<<<.....>>>>>..<<.....<<<<..<<...<<<<<<...<.......>.>>>>>>....((<<<.<<...<<<...<<<....>>>......<<....>>...>>.>....>>...<<<<<........>>>>>))<<<<<<<<...<<<....>>>..<<<<<<<<<<...<<<..<<<<<<<<<<<<<<<<<...{{{...>>>>>....<<<<<<...<<<<<<....<<.....>>......>>>>>>...>>>>>>..>>>>>.>>>>>>>..>>>.........>>>>>>>>>>...>>>>>>>>.>>>..>>..<<......>>.>>>>.<<<<.....>>>>..>>....<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<..>>>..>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<....>>>>......>>>>>>>...<<..<<<..<<<<<<.<...<<....<<<.<....>.>>>....>>.>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>....>>....<<<<<........>>>>>...((((((..{{{.........{{{..{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<<<<<<<<<..........<<<<<....................>>>>>.>>>>>>>>.>>>>>>>>>...<<<<......>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<.<<<<.......>>>>.>.....<<...(((>>....>>>>>>>...<<<<<<<<.........>>>>>>>>.<<<....>>>.>>)))......((((((.(((((.>>>>>>))))))))))).........]]]]..}}.}}}.......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<.........>>>....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........}}}.))))))..<<<<<..<<<..<<<<<<<<...............>>>>>>>><<<<<...<.<<...<<<<<<<<<<}}}.>>>>>..>>>>>...>>.>.>>>>>.<<<...<<<<<<...........>>>>>>...>>>..>>>..>>>>>....<<<<<<............................>>>>>>...<<.<<<<.......>>>>..<<<<<<<<<<<....<<<<....<<...>>...>>>>...>>>>.>>>>>.>>.....>>.. .........................((((((.....(...[..)......))))).).........((....))...((((.....((.]...)).....))))...((((..(((...(...).....)))(((......((((......)))).[[(...).(((.....]])))....))))....(((((((........)))))))...(((((..[[[[[[)))))..)))..................................((....))............(...(((....)))...........)................((((((..))))))[((((........)))).(((((..(.(((((((((((((..((....(((....)))...))...((....))....(......)(((((((((((((....))))))).))))))...)))))))))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))).((((((....(((((....)))))((((((((((.(((.(((((((((...(((...(((..((((((...(((..........))).))))))..)))..)).)...)))))))..(((((((((.........)))))))))....))))))))))))).))..((((..((((.....))))..))))....(((......)))...(((((((...((([[[...(((((((........(((.(.((((((((............)))))))).))))..........]]]......))))))))))...)))))))(((((....)))))....))))))(.((((((((...((......(((((.((....)).)))))...))))))))))..).....))))).((.....((.....(((((.....)))))..((.....((((..((..(((((((...(.......).))))))....[[(((.((...(((...(((....))).(....((....)).).)).)....))...(((((........)))))]]((((((((...(((....)))...(((((((((...(((..(((((((((((((((((.(.{{{)..)))))....((((((...((((((....((.....))......))))))...))))))..))))).)))))))..)))(...)....)))))))))....)))))))).))).)))..((......)).)))).((((.....))))..))....((((....((((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((..))..)))))).))(...).......(((((((((.].((.........))...(((((((....(((......)))......))))))).}.(((.(((..((((((.(...((....(((.(....).)))....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)).{..(((((.....]}.)))))...((((((..(((.((......(((..((((((..(((((.((((((((..((((((((((((.((((..........(((((..(....)............))))).)))).))).)))))))))...((((......)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.(.((((.......)))).)...).((][.[[[))....)))))))...((((((((.....{...)))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....)}....))))..)).))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(((((((((......))))))..))).(((.(.....).)))....)))))..)...))).).....(((((((....))).))))..>.))..))).))))))..(((((..(((..((((((((.....(....)....))))))))(((((...(.((...((((((((((}}}.)))))..)))))...)).).))))).(((....((((.............))))....)))..)))..)))))....((((((........(..)................))))))...((.((((.......))))..(((((((((((....((((.(..((...))..)))))...)))).))))).)).....)).. Giardia ribosome chimeric hybrid-like GDP+Pi bound state (B1); Large Subunit rRNA 8bsi Lu 75 3.4 RF00005 URS0000326EAC_5741 36912103 0030533 0006412 5741 agcagaguggcgcagcggaagcgugcugggcccauaacccagaggucgauggaucgaaaccauccucugcuacca <<<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((....[..)))).(((((.......))))).....(((((..]....)))))))))))).... Giardia ribosome chimeric hybrid-like GDP+Pi bound state (B1); E-site tRNA 8bsi St 1454 3.4 RF01960,RF02542,RF01959,RF00177 URS00026813B3_5741 36912103 0003735 0005840 5741 cauccggucgauccugccggagcgcgacgcucuccccaaggacgaagccaugcaugcccgcucacccgggacgcggcggacggcucaggacaacgguugcaccccccgcggcggucccugcuagccggacaccgcuggcaacccggcgccaagacgugcgcgcacgggcgcgcgccccgcgggcgagcagcgugacgcagcgacggcccgcccgggcuuccggggcaucacccggucggcgcggucgcggcgcgccgagggcccgacgccuggcggagaaucaggguucgacuccggagagcgggccugcgagacggcccgcacauccaaggacggcagcaggcgcggaacuugcccaaugcgcggcgcgcgaggcagcgacggggagcgcgcgagcgaggcgggcccacagcccccgccgcgcagccgagggcaaggucugugccagcagccgcgguaauuccagcucggcgagcgucgcgcggcgcugcugcaguugaaacgcccguaguuggccccccgccgccacgaggaaacgggagcgcuccaggcaggcccguuggccccgccgcgugggaccgcgcagcgggcgcggcgcgccgccgccgcagccccgaggagagcgggcgggggcaccgguaccggccggggacgggugaaacaggaugaucccgccgagaccgccggccgcgcaggcgccugccaagaccgccucugucaaucaagggcgaaggccgggggcuagaaggcgaucagacaccaccguauucccggccguaaacggugccgccccgcggccggcgcgcgcgucccgccggccgcccagggaaaccgggaggcuccgggcucuggggggaguauggccgcaaggcugaaacuugaaggcauugacggagggguaccaccagacguggagucugcggcucaaucugacucaacgcgcgcaccucaccaggcccggacgcgcggaggaccgacagccgggcgcgcuuucgcgaucgcgcgggugguggugcauggccgcucccagcccguggcgcgagccgucugcuccauugcgacaacgagcgagaccccggccgcgggcgccgcgggacggcccgcggcagcgggaggacggcggggcgauagcaggucugugaugcccucagacgcccugggccgcacgcgcgcuacacuggcggggccagccggcgcccgccaggacgcgcggagcccccgccguggccgggaccgcgggcuggaacgcccccgcgcaccaggaaugucuuguaggcgcccgcccccaccgcgcgccggacgcgucccugccccuuguacacaccgcccgucgcuccuaccgacugggcgcggcggcgagcgccccggacgcgcgaagggccgcgagcccccgcgccuggaggaaggagaagucguaacaagguauccguaggugaaccugcggauggauccuu ...<<<<<.[..(((>>>>>.<<<<<<<<<..<<<<<..<......<<<.<<<..<<<.<<...........>>>>>......<<........<<<..<<..<<...<<<<<.............<<.....<<<<<<....>>>>>>......>>...<....<.<.<<<<...[.[...<.....>..>>>>.>>...>....>.>>>>..>>>>..>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>...<<<<<<<<....>>>>...>>>>.>>.<<<<<<..........>>>>>>.<.<<<..>>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>>>>............<<<<<<.........>>>>>>.....<<<<<<<......[..[.....((..>>)).......]..].>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.......<<<.<<<<<<.......<<..<<.......>>...........>>......>>>>>..>.>>>..<<<<<<.....].]..>>>..>>>..........<<<<<<<.....<<<<..<<..<<<<<.<<<..<.<......>.>.....>>>.>>>>.>.>>......<<<....>>>..>>>>....>>>>.>>>...>>>...>>>>...<<<<<<<<...<...<<.<.........>.>>...>>>>>>>>>.........<<<.<<..<<<<<<<<<<.<.....>.>>>>>>>>>>...<<..))>>....>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..)))..]<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>.........<<<<<......<<<<<<......<<<.<<<.......>>>.>>>....>>>>>>...<..<<<..<<.<<<<<<....<<.<<<<<<....>>>....<<......>>....>>>.>>....<<<<..<<<<<<...>>>>>>.....<<<<<....>>>>>........>>>>....>>>.>>>.....>>>>>.>.......>>>>>...>>.>>>>.>>>.....<<<<<<<.......<<<.<<....>>.>>>.......>>>>>>>...........<<.<<<<......>>>>.>>..........>>>>>>....<<<<<.<<.......>>.>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<<.<<....<<<<<<<<.<<<..<<<.<<<...........>>>.>>>..>>>.>>>>>>>>...>>.>>>>>..>.>>...>.....<<<<<<<<<<..>>>>>>>>>>........ ...((((..[..[[..)))).(((((((((..(((((..((.....(((.(((..(((.((...........)))))......(((.......(((..((..((...((((..........(...((.....((((((....))))))......))...(........((((...{.{...(.....)..))))......).)....))))..))))..))).(((....(((..((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((((((..........)))))).(.((....)).)...)))))).).....(.(((...(((((...)))).))))).)...)))))............((((((.........)))))).....((((([[......(..(.....((..]])).......)..).)))))..)))))))))...[......((([[...(.((((...(((.......(.(.((((((.(.....((..((.......)).(..)......))...)..)))))..).).)..((((((.....}.}..))).).)).........((((((((.(...((((..(((..((((.((...(..........)......)).))))..))).......((....))...))))..).)))).)))..))))...))))....((((((....(...((.(.........).))...).))))))......{...(((.((..((((((((((.((..).).))))))))))...((..]]))....))...].))))))).(((......((((....))))....)))...]]..](((((.(((((((..((..(((((..(((.((((((......((........)).........(((((.(....(((((.....(.(((.(((.......))).)))...).)))))......(((...(.((((((....((.((((((....)))..(.((......)))...))).))....((.(..((((((...))))))..(..(((((....))))).....)..).))....))).))).....).))).......).)))))...)).)))).))).(...((((((......(.(((.((....)).)))...)....))))))......(....((.((((......)))).))....)..)..))))).....(((((.((.......)).)))))......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(((.(((...........))).)))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}....... Giardia ribosome chimeric hybrid-like GDP+Pi bound state (B1); Small Subunit rRNA 8bsi y 11 3.4 36912103 5741 aaaauggauaa ........... ........... Giardia ribosome chimeric hybrid-like GDP+Pi bound state (B1); mRNA 8bsj LD 140 6.49 RF00002 URS000268138A_5741 36912103 0003735 0005840 5741 cacgccccgccggcggaugccucggcccgggcggcgacgaagagcgcggcggagcgcgagacgcggugcggacccgcccgccccgagaagcaccgauccucgaacgcagcgcgccccggcgccgccgccucggcgccugc .........................................<<<<<<.((.....>>>.....<<<<<<...<..))..>.........>>>>>>...>>>....<<...>><<<..>>>.................... .........................................((((((.[[.....))).....((((((...(..]]..).........))))))...)))....((...))((....)).................... Giardia Ribosome in PRE-T Classical State (C); 5.8S rRNA 8bsj LE 116 6.49 RF00001 URS00026813A5_5741 36912103 0003735 0005840 5741 guucggccauccuacggcggaaacuccuuaacucguuccgaauuaggaagagaagcgccgucaggccccgccaguacugcgaucggagacgucgugggaacacggggugccgaacu <<<<<<<....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>><<<<<<......<<<<<<.<<....>>>>>>>>.....>>>>>>>>>>>>>. (((((((....((((((((.....((((((...(.....)...))))..))....)))))).))((((((......((((((.((....)))))))).....))))))))))))). Giardia Ribosome in PRE-T Classical State (C); 5S rRNA 8bsj Lt 2593 6.49 RF02543 URS0002681395_5741 36912103 0003735 0005840 5741 ggcgggccugaggcggcgggggcgacgggcggaacuuaagcauaucaguacgccccggaggagaaaccaaccgggauuccccgcuagcggcgagcgacgcgggaggagcccgccccgaaggcgcgcuguggggccgcgagggggcccgagggccccgcccgagagggugcaagccccguacggcgaguagcgcugcuugagcgugcagcgcgaagggaggcgcggcccuuccaaggcuaaauacgccccgggaccgauagcggaccaaguagcgcgagcgaacggugaaaaggacgcccugcggccgcucaaaagaccugaacccggccggccgccggcccgccggccccgucucgaaacacggaccgaggagccacgcgccgcggcgagcccgagggagcccccgcggcggagcgagcgcgagacgccccgggcccgccaugccccugcgggcgugcgcgggccgagccgcggcgcgugggcccgaaaggcggugaucuaugcccggcgagggcgaggccgggcgaaagccugguggaggcccgccgcggugcugacgcgcagaucgcucgucggagccgggcaugggggcgaaagacucaucgaaccgccugguagcugguugccuccgaaaugucucccaggacagccgccgccccgcaguugcggcccguagagcgcuggccggcgggagcggggggccugccccucgcccgccccccaaacuccgaagggccgcgccgccccgccgcuggccugggcggggcgggcgaaugcgggcggcgcgugggccccuccugguaagcaggacgggcgaggcgggacgauccggacgccgggccagggugcgccgccggggcccgcggaacggcgucggccggucccgacagccgaaucggccggcccggaaaauggagcgcgccggagccccggacccgcgcccggccgccgcgcgcggcggguaggaggccgcagaggccccgggggcgaaggcggcgcgcaggccccgccggaccggccucuggugcagaucucggcagcaguagccgcuacuccgcgccccggaggacugagggggagacggguuccgcggcgccugcaucuggccgcgggugacucgggccuaagcggcgggugaagaccgggaaggggcgcccgcccgucgaacggggagccggcggagacuccggcaggcgcggcccccgcggagacgcccgccccccggcgacgcgcacggggaccgcggcgggcggcgccccggcccgcgaacgccccgcagcccccggacgccuugcgcggagaggggggcccgggggcggaccgcgcguccccggccgccccugaaaagccggggggcgccggccgcgcgccguaccgaccgcagcaggacuccggggucagcagccucuagcgcgggagcgaacgcggcucagggaagucggcaagccggcuccguaaccucgggaaaaggaguggcucugacggcgccgggucagaacuggaacggacgcggggaucccgacuguuuacuagaaacacagcgucgcgagggccgcacccggcgcuggcgcgacgugauuucugcccagugccacgaccgucaccgugaagcgauccgccgaagcccugguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucgggcaauuuccgacgugcaugaauggaccaacgaggaucccacugucccgagccgcgccuccgcgagccuccagccucgggaacgggcgagggccggccagcggggcaagaagacccuuuugagcuugacuccagcccgggccuguggggcggggcggccggcgcagcgcacaggggaggccgcgccccugagacacccugacggccgccgccgccccgcucacccggucgcgcggggacccgcccgggcggggaguucggcuggggcggcgcgccugcuacaccggaccgcaggcgucccacggcgggcucagcgaggacggagaccucccgcggagcagaagggcacaagcccgcccgacccgcgccccccgugccggcgcgggccgcgaaagcggggccuaccgauccuucgccgccccggccgcgggcgcggagguggcagaaaaguuaccacagggauaacuggcuuguggccgccgagcgcccgcagcgacgcggcuuuuugauccuucgaugucggcucuuccuaccguccgcgcgcaccggcgcggaagcgucggauuguucacccguucaagggaucgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacuggccccggggccagagcacggcgggccaguacgagaggaacgcccgccgcgggccgccagccccgcgguugcccggccgggcagcgccgcgccgccgcgcccgggggcccugcgcugaccgccucuaagcgcgcaccccgccucgcgccccgcccggccgcgcgccccagccccgugccccgucgccgagcggcccccgcccggggagaccacccggcgcggcgcuccuguacggcgcagagcccugcgaucgccugagggacgcgccugcagagcgcgg .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<....<<.....>>...>.>>>>>..<<<...<<<<...........>>>><<<<....<<<<<......>>>>>((......<<<.....))>>>...>>>>.....<<<<<<<........>>>>>>>...<<<<<..((((((>>>>>..>>>..................................<<....>>................<<<....>>>............................<<<<<<..>>>>>>.<<<<........>>>>.<<<<<....<<<<<<<<<<<<<..<<<...<<<....>>>..>>>...<<....>>............<<<<<<<<<<<<<....>>>>>>>.>>>>>>...>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<<.<<<.<<<<<<<<<...<<<...<<<..<<<<<..<<<<<..........>>>>>>>>>>..>>>..>>.>...>>>>>>>.<<<<<<<<<<.........>>>>>>>>>>...>>>>>>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((...<<<<<<<........<<<.<<<<<<<<<..............>>>>>>>>>>>>..........)))......>>>>>>>>>>>..>>>>>>><<<<<....>>>>>....>>>>>><<<<<<<<<<...<<......<<<<<.<<....>>.>>>>>...>>>>>>>>>>.>>.....>>>>>.<<.....<<.....<<<<<.....>>>>>..<<<....<<<<..<<...<<<<<<...<.......>.>>>>>>....((<<<.<<...<<<...<<<....>>>......<<<..>>>...>>.>....>>...<<<<<........>>>>>))<<<<<<<<...<<<....>>>..<<<<<<<<<<...<<<..<<<<<<<<<<<<<<<<<...[[[...>>>>>....<<<<<<...<<<<<<....<<.....>>......>>>>>>...>>>>>>..>>>>>.>>>>>>>..>>>.........>>>>>>>>>>...>>>>>>>>.>>>..>>..<<......>>.>>>>.<<<<.....>>>>.>>>....<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<.<<<<<<<<..>>>..>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<......>>>......>>>>>>>...<<..<<<..<<<<<<.<...<<....<<<.<....>.>>>....>>.>>>>>..>>>>>.<<<<<.......>>>>>.........<...........<<<<<<.....>>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>....>>.(..<<<<<......).>>>>>...<<<<<<..<<<.<<......<<<..<<<<<<..<<<<<.<<<<<<<<..<<<<<<<<<.<<<...<..........<<.<......................>.>>.>...>>>..>>>>>>>>>...<<<<......>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<.<<<<.......>>>>.>.....<<...(((>>....>>>>>>>...<<<<<<<<.........>>>>>>>>.<<<....>>>.>>)))......<<<<<<<.<<<<.))))))>>>>>>>>>>>.........>>>>..>>.>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<.<.....>.>>>....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>>..<<<<<..<<<..<<<<<<<<...............>>>>>>>><<<<<...<.<<...<<<<<<<<<<]]].>>>>>..>>>>>...>>.>.>>>>>.<<<...<<<<<<...........>>>>>>...>>>..>>>..>>>>>....<<<<<<............................>>>>>>...<<.<<<<.......>>>>..<<<<<<<<<<<....<<<<....<<...>>...>>>>...>>>>.>>>>>.>>.....>>.. .........................((((((.....(...[..)......))))).).........((....))...((((.....((.]...)).....))))...((((..(((...(...).....))).((......((((......)))).[[(...).(((.....]])))....)).)....(((((((........)))))))...(((((..[[[[[[)))))..)))..................................((....))............(...(((....)))...........)................((((((..))))))[((((........)))).(((((..(.(((((((((((((..((....(((....)))...))...((....))....(......)(((((((((((((....))))))).))))))...)))))))))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))).((((((....(((((....)))))((((((((((.(((.(((((((((...(((...(((..(((((...((((..........)))).)))))..)))..)).)...)))))))...((((((((.........)))))))).....))))))))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(((((((........(((.(.((((((.(............).)))))).))))..........]]]......))))))))))...)))))))(((((....)))))....))))))((((((((((...((......(((((.((....)).)))))...)))))))))).)).....))))).((.....((.....(((((.....)))))..((.....((((..((..(((((((...(.......).))))))....[[(((.((...(((...(((....))).(....(((..))).).)).)....))...(((((........)))))]]((((((((...((......))...(((((((((...(((..(((((((((((((((((.(.{{{)..)))))....((((((...((((((....((.....))......))))))...))))))..))))).)))))))..)))(...)....)))))))))....)))))))).))).)))..((......)).)))).((((.....))))..))....((((....((((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((..))..)))))).))(...).......(((((((((.].((.........))...(((((((....(((......)))......))))))).}.(((.(((..((((((.(...((....(((.(....).)))....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)).{..(((((.....]}.)))))...((((((..(((.((......(((..((((((..(((((.((((((((..(((((((((..(....(...........(((......................)))..)....)...)))))))))...((((......)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((....((((((.(.(.((((.......)))).)...).((][.[[[))....))))))....((((((((.....{...)))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....)}....))))..)).))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(((((((((......))))))..))).(((.(.....).)))....)))))..)...))).).....(((((((....))).))))..>.))..))).))))))..(((((..(((..((((((((.....(....)....))))))))(((((...(.((...((((((((((}}}.)))))..)))))...)).).))))).(((....((((.............))))....)))..)))..)))))....((((((........(..)................))))))...((.((((.......))))..(((((((((((....((((.(..((...))..)))))...)))).))))).)).....)).. Giardia Ribosome in PRE-T Classical State (C); Large Subunit rRNA 8bsj St 1454 6.49 RF01960,RF02542,RF01959,RF00177 URS00026813B3_5741 36912103 0003735 0005840 5741 cauccggucgauccugccggagcgcgacgcucuccccaaggacgaagccaugcaugcccgcucacccgggacgcggcggacggcucaggacaacgguugcaccccccgcggcggucccugcuagccggacaccgcuggcaacccggcgccaagacgugcgcgcacgggcgcgcgccccgcgggcgagcagcgugacgcagcgacggcccgcccgggcuuccggggcaucacccggucggcgcggucgcggcgcgccgagggcccgacgccuggcggagaaucaggguucgacuccggagagcgggccugcgagacggcccgcacauccaaggacggcagcaggcgcggaacuugcccaaugcgcggcgcgcgaggcagcgacggggagcgcgcgagcgaggcgggcccacagcccccgccgcgcagccgagggcaaggucugugccagcagccgcgguaauuccagcucggcgagcgucgcgcggcgcugcugcaguugaaacgcccguaguuggccccccgccgccacgaggaaacgggagcgcuccaggcaggcccguuggccccgccgcgugggaccgcgcagcgggcgcggcgcgccgccgccgcagccccgaggagagcgggcgggggcaccgguaccggccggggacgggugaaacaggaugaucccgccgagaccgccggccgcgcaggcgccugccaagaccgccucugucaaucaagggcgaaggccgggggcuagaaggcgaucagacaccaccguauucccggccguaaacggugccgccccgcggccggcgcgcgcgucccgccggccgcccagggaaaccgggaggcuccgggcucuggggggaguauggccgcaaggcugaaacuugaaggcauugacggagggguaccaccagacguggagucugcggcucaaucugacucaacgcgcgcaccucaccaggcccggacgcgcggaggaccgacagccgggcgcgcuuucgcgaucgcgcgggugguggugcauggccgcucccagcccguggcgcgagccgucugcuccauugcgacaacgagcgagaccccggccgcgggcgccgcgggacggcccgcggcagcgggaggacggcggggcgauagcaggucugugaugcccucagacgcccugggccgcacgcgcgcuacacuggcggggccagccggcgcccgccaggacgcgcggagcccccgccguggccgggaccgcgggcuggaacgcccccgcgcaccaggaaugucuuguaggcgcccgcccccaccgcgcgccggacgcgucccugccccuuguacacaccgcccgucgcuccuaccgacugggcgcggcggcgagcgccccggacgcgcgaagggccgcgagcccccgcgccuggaggaaggagaagucguaacaagguauccguaggugaaccugcggauggauccuu ...<<<<<.[..(((>>>>>.<<<<<<<<<..<<<<..........<<<.<<<..<<<.<<...........>>>>>......<<........<<<..<<..<<...<<<<..............<<.....<<<<<......>>>>>......>>........<.<.<<<<...[.[...<.....>..>>>>.>>..........>>>>..>>>>..>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>...<<<<<<<<....>>>>...>>>>.>>.<<<<<<..........>>>>>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>.......>>>>............<<<<<<.........>>>>>>.....<<<<<<<......[........((..>>))..........].>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.......<<<.<<<<<<.......<<..<<.......>>...........>>......>>>>>..>.>>>..<<<<<<.....].]..>>>..>>>..........<<<<<<<.....<<<<..<<..<<<<<.<<<..<.<......>.>.....>>>.>>>>.>.>>......<<<....>>>..>>>>....>>>>.>>>...>>>...>>>>...<<<<<<<<...<...<<.<.........>.>>...>>>>>>>>>.........<<<.<<..<<<<<<<<<<.........>>>>>>>>>>...<<..))>>....>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..)))..]<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<........<<........>>.........<<<<<.<....<<<<<<......<<<.<<<.......>>>.>>>....>>>>>>...<<.<<<..<<.<<<<<<....<<.<<<<<<....>>>....<........>....>>>.>>....<<<<..<<<<<<...>>>>>>.....<<<<<....>>>>>........>>>>....>>>.>>>.....>>>>>>>.....>.>>>>>......>>>>.>>>.....<<<<<<<.......<<<.<<....>>.>>>.......>>>>>>>...........<<.<<<<......>>>>.>>..........>>>>>>....<<<<<.<<.......>>.>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<<.<<....<<<<<<<<.<<<..<<<.<<<...........>>>.>>>..>>>.>>>>>>>>...>>.>>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>........ ...((((..[..[[..)))).(((((((((..(((((..((.....(((.(((..(((.((...........)))))......(((.......(((..((..((...((((..............((.....((((.(....).))))......))...(....(...((((.....{...(.....)..))))..)...)......))))..))))..))).(((....(((...(((((((.......))))))).)))......)))...(((.((((....))))....)))))).((((((..........)))))).(.((....)).)...)))))).).....(.(((...(((((...)))).))))).)...)))))...(..)......(((((.........)))))......((((([[......(..(.....((..]])).......)..).)))))..)))))))))...[......((([[.....((((...(((.......(((.((((((.(.....((..((.......))...........))...)..)))))..).)))..(((.((.....}....).).).)).........((((((((.(...((((..(((..((((..((..(..........)......).)))))..))).......((....))...))))..).)))).)))..))))...))))....((((((....(...((.(.........).))...).))))))......{...(((.((..((((((((((.((..).).))))))))))...((..]]))....))...].))).))).(((......((((....))))....)))...]]..](((((.(((((((..((..(((((..(((.((((((......((........)).........(((((.(....(((((.....(.(...(((.......)))...)...).)))))...((..((...(.((((((....((.((((((....)))..(.(........))...))).))....(((...((((((...))))))..(..(((((....))))).....)..).))....))).))).....).)).)).....).)))))...)).)))).))).(...(..(((........(((.((....)).)))........)))..)......(....((.((((......)))).))....)..)..))))).....(((((.((.......)).)))))......))...)))))))))).))..(.(..((.(..((((.((..(..(((((((.(((..(((.(((...........))).)))..))).))))))).)..)).))))...).))...)..)..((((((((......))))))))}....... Giardia Ribosome in PRE-T Classical State (C); Small Subunit rRNA 8bsj u 75 6.49 RF00005 URS0000326EAC_5741 36912103 0030533 0006412 5741 agcagaguggcgcagcggaagcgugcugggcccauaacccagaggucgauggaucgaaaccauccucugcuacca <<<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... ((((((...(((.........)))..((((.......))))......((.............)).)))))).... Giardia Ribosome in PRE-T Classical State (C); tRNA 8bsj v 75 6.49 RF00005 URS0000326EAC_5741 36912103 0030533 0006412 5741 agcagaguggcgcagcggaagcgugcugggcccauaacccagaggucgauggaucgaaaccauccucugcuacca <<<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... ..(((((..(((.........))).(((((.......))))).....((((.........)))))))))...... Giardia Ribosome in PRE-T Classical State (C); tRNA 8bsj x 74 6.49 URS00026813D2_5741 36912103 5741 gcggauuuacucagaagggagagcaccagaauaucaaaauggaguccuguguucgauccacagaauucgcacca <<<<<<<..<<<........>>>..<<<...........>>>....<<<<<.......>>>>>>>>>>>>.... ((..(((...((.....[..))...(((...........)))....(((((..]....))))))))..)).... Giardia Ribosome in PRE-T Classical State (C); tRNA 8bsj y 11 6.49 36912103 5741 aaaauggauaa ........... ........... Giardia Ribosome in PRE-T Classical State (C); mRNA 8btd LD 142 4.9 RF00002 URS000268138A_184922 36912103 0003735 0005840 184922 gcacgccccgccggcggaugccucggcccgggcggcgacgaagagcgcggcggagcgcgagacgcggugcggacccgcccgccccgagaagcaccgauccucgaacgcagcgcgccccggcgccgccgccucggcgccugcc ..........................................<<<<<<<((....>>>>.....<<<<<<...<..))..>.........>>>>>>...>>>....<<...>><<<..>>>..................... ..........................................((((((.[[.....))).....((((((...(..]]..).........))))))...)))....((...))((....))..................... Giardia Ribosome in PRE-T Hybrid State (D1); 5.8S rRNA 8btd LE 117 4.9 RF00001 URS00026813A5_184922 36912103 0003735 0005840 184922 aguucggccauccuacggcggaaacuccuuaacucguuccgaauuaggaagagaagcgccgucaggccccgccaguacugcgaucggagacgucgugggaacacggggugccgaacu <<<<<<<<....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>><<<<<<......<<<<<<.<<....>>>>>>>>.....>>>>>>>>>>>>>> ((((((((....((((((((.....((((((...(.....)...))))..))....)))))).))((((((......((((((.((....)))))))).....)))))))))))))) Giardia Ribosome in PRE-T Hybrid State (D1); 5S rRNA 8btd Lt 2593 4.9 RF02543 URS0002681395_184922 36912103 0003735 0005840 184922 ggcgggccugaggcggcgggggcgacgggcggaacuuaagcauaucaguacgccccggaggagaaaccaaccgggauuccccgcuagcggcgagcgacgcgggaggagcccgccccgaaggcgcgcuguggggccgcgagggggcccgagggccccgcccgagagggugcaagccccguacggcgaguagcgcugcuugagcgugcagcgcgaagggaggcgcggcccuuccaaggcuaaauacgccccgggaccgauagcggaccaaguagcgcgagcgaacggugaaaaggacgcccugcggccgcucaaaagaccugaacccggccggccgccggcccgccggccccgucucgaaacacggaccgaggagccacgcgccgcggcgagcccgagggagcccccgcggcggagcgagcgcgagacgccccgggcccgccaugccccugcgggcgugcgcgggccgagccgcggcgcgugggcccgaaaggcggugaucuaugcccggcgagggcgaggccgggcgaaagccugguggaggcccgccgcggugcugacgcgcagaucgcucgucggagccgggcaugggggcgaaagacucaucgaaccgccugguagcugguugccuccgaaaugucucccaggacagccgccgccccgcaguugcggcccguagagcgcuggccggcgggagcggggggccugccccucgcccgccccccaaacuccgaagggccgcgccgccccgccgcuggccugggcggggcgggcgaaugcgggcggcgcgugggccccuccugguaagcaggacgggcgaggcgggacgauccggacgccgggccagggugcgccgccggggcccgcggaacggcgucggccggucccgacagccgaaucggccggcccggaaaauggagcgcgccggagccccggacccgcgcccggccgccgcgcgcggcggguaggaggccgcagaggccccgggggcgaaggcggcgcgcaggccccgccggaccggccucuggugcagaucucggcagcaguagccgcuacuccgcgccccggaggacugagggggagacggguuccgcggcgccugcaucuggccgcgggugacucgggccuaagcggcgggugaagaccgggaaggggcgcccgcccgucgaacggggagccggcggagacuccggcaggcgcggcccccgcggagacgcccgccccccggcgacgcgcacggggaccgcggcgggcggcgccccggcccgcgaacgccccgcagcccccggacgccuugcgcggagaggggggcccgggggcggaccgcgcguccccggccgccccugaaaagccggggggcgccggccgcgcgccguaccgaccgcagcaggacuccggggucagcagccucuagcgcgggagcgaacgcggcucagggaagucggcaagccggcuccguaaccucgggaaaaggaguggcucugacggcgccgggucagaacuggaacggacgcggggaucccgacuguuuacuagaaacacagcgucgcgagggccgcacccggcgcuggcgcgacgugauuucugcccagugccacgaccgucaccgugaagcgauccgccgaagcccugguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucgggcaauuuccgacgugcaugaauggaccaacgaggaucccacugucccgagccgcgccuccgcgagccuccagccucgggaacgggcgagggccggccagcggggcaagaagacccuuuugagcuugacuccagcccgggccuguggggcggggcggccggcgcagcgcacaggggaggccgcgccccugagacacccugacggccgccgccgccccgcucacccggucgcgcggggacccgcccgggcggggaguucggcuggggcggcgcgccugcuacaccggaccgcaggcgucccacggcgggcucagcgaggacggagaccucccgcggagcagaagggcacaagcccgcccgacccgcgccccccgugccggcgcgggccgcgaaagcggggccuaccgauccuucgccgccccggccgcgggcgcggagguggcagaaaaguuaccacagggauaacuggcuuguggccgccgagcgcccgcagcgacgcggcuuuuugauccuucgaugucggcucuuccuaccguccgcgcgcaccggcgcggaagcgucggauuguucacccguucaagggaucgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacuggccccggggccagagcacggcgggccaguacgagaggaacgcccgccgcgggccgccagccccgcgguugcccggccgggcagcgccgcgccgccgcgcccgggggcccugcgcugaccgccucuaagcgcgcaccccgccucgcgccccgcccggccgcgcgccccagccccgugccccgucgccgagcggcccccgcccggggagaccacccggcgcggcgcuccuguacggcgcagagcccugcgaucgccugagggacgcgccugcagagcgcgg .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<.....<<.....>>.....>>>>>..[[[...<<<.............>>>.<<.....<<<<<......>>>>>((......<<<.....))>>>....>>......<<<<<<<........>>>>>>>...(((((..<<<<<<)))))..]]]..................................<<....>>................<<<....>>>............................<<<<<<..>>>>>>.<<<<........>>>>.<<<<<....<<<<<<<<<<<<<..<<<...<<<....>>>..>>>...<<....>>............<<<<<<<<<<<<<....>>>>>>>.>>>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<<.<<<.<<<<<<<<<...<<<...<<<..<<<<<..<<<<............>>>>>>>>>..>>>..>>.>...>>>>>>>.<<<<<<<<<<.........>>>>>>>>>>...>>>>>>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((...<<<<<<<........<<<.<<<<<<<<<..............>>>>>>>>>>>>..........)))......>>>>>>>>>>>..>>>>>>><<<<<....>>>>>....>>>>>>..<<<<<<<<...<<......<<<<<.<<....>>.>>>>>...>>>>>>>>>>........>>>>>.<<.....<<.....<<<<<.....>>>>>..<<.....<<<<..<<...<<<<<<...<.......>.>>>>>>....((<<<.<<...<<<...<<<....>>>.................>>.>....>>...<<<<<........>>>>>))<<<<<<<<...<<<....>>>..<<<<<<<<<<...<<<..<<<<<<<<<<<<<<<<<...{{{...>>>>>....<<<<<<...<<<<<<...<<<.....>>>.....>>>>>>...>>>>>>..>>>>>.>>>>>>>..>>>.........>>>>>>>>>>...>>>>>>>>.>>>..>>..<<......>>.>>>>.<<<<.....>>>>..>>....<<<<....<<<<<<<<.<<...............<<<<<....<....>.....>>>>><<.<<<<<<<....>>..>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<....>>>>......>>>>>>>...<<..<<<..<<<<<<.<...<<....<<<.<....>.>>>....>>.>>>>>..>>>>><<<.............>>>........<...........<<<<<<.....>>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>....>>....<<<<<........>>>>>...((((((..{{{.........{{{..{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<<<<....<..........<<<<......................>>>>.>....>>>.>>>>>>>>>...<<<<......>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<.<<<<.......>>>>.>.....<<...(((>>....>>>>>>>...<<<<<<<<.........>>>>>>>>.<<<....>>>.>>))).......(((((.(((((.>>>>>>))))))))))..........]]]]..}}.}}}.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<.........>>>....>>>>>......>>>.>>....<<<<<<<....>>>.>>>>........}}}.))))))..<<<<<..<<<..<<<<<<<<...............>>>>>>>><<<<<...<.<<...<<<<<<<<<<}}}.>>>>>..>>>>>...>>.>.>>>>>.<<<...<<<<<<...........>>>>>>...>>>..>>>..>>>>>....<<<<<<............................>>>>>>...<<.<<<<.......>>>>..<<<<<<<<<<<....<<<<.<..<<...>>..>>>>>...>>>>.>>>>>.>>.....>>.. .........................((((((.....(...[..)......))))).).........((....))...((((.....((.]...)).....))))...((((..(((...(...).....))).((......((((......)))).[[(...).(((.....]])))....)).)....(((((((........)))))))...(((((..[[[[[[)))))..)))..................................((....))............(...(((....)))...........)................((((((..)))))).((((........)))).(((((....(((((((((((((..((....(((....)))...))...((....))....(......)(((((((((((((....))))))).))))))...)))))))))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...).)))...(((..((.((.......<)))).)))....)))))))))...((.......))......))))))......).))..((((((....(((((....)))))((((((((((.(((.(((((((((...(((...(((..(((((..(((...(.....)....))))))))..)))..)).)...))))))).((((((((((.........))))))))))...))))))))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(((((((........(((.(.((((((((............)))))))).))))..........]]]......))))))))))...)))))))(((((....)))))....))))))(.((((((((...((......(((((.((....)).)))))...))))))))))..).....))))).((.....((.....(((((.....)))))..((.....((((..((..(((((((...(.......).))))))....[[(((.((....((...(((....))).(....(......).).))......))...(((((........)))))]]((((((((...((......))...(((((((((...(((..(((((((((((((((((...{{{...)))))....((((((...((.(((....((.....))......))).))...))))))..))))).)))))))..)))(...)....)))))))))....)))))))).))).)))..((......)).)))).((((.....))))..))....((((....((((((((.((..(....(.......(((((....(.[..).....)))))((.((((((........)))))).))(...).......(((((((((...((.........))...(((((((....(((......)))......))))))).].(((.(((..((((((.(...((....(((.(....).)))....)).)))))..))))).((.............)).........((.(......).(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....))[[..(((((......]])))))...((((((..(((.((......(((..((((((..(((((.((((((((..(((((((((.((....(..........((((......................)))).)....))..)))))))))...((((......)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.(.((((.......)))).)...).((][.[[[))....)))))))...((((((((.....{...)))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....)}....))))..)).))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(((((((((......))))))..)))..((.(.....).)).....)))))..)...))).)......((((((....))).)))...>.))..))).))))))..(((((..(((..((((((((.....(....)....))))))))(((((...(.((...((((((((((}}}.)))))..)))))...)).).))))).(((....((((.............))))....)))..)))..)))))....((((((........(..)................))))))...((.((((.......))))..((.((((((((....((((.(..((...))..)))))...)))).))))..)).....)).. Giardia Ribosome in PRE-T Hybrid State (D1); Large Subunit rRNA 8btd St 1454 4.9 RF01960,RF02542,RF01959,RF00177 URS00026813B3_184922 36912103 0003735 0005840 184922 cauccggucgauccugccggagcgcgacgcucuccccaaggacgaagccaugcaugcccgcucacccgggacgcggcggacggcucaggacaacgguugcaccccccgcggcggucccugcuagccggacaccgcuggcaacccggcgccaagacgugcgcgcacgggcgcgcgccccgcgggcgagcagcgugacgcagcgacggcccgcccgggcuuccggggcaucacccggucggcgcggucgcggcgcgccgagggcccgacgccuggcggagaaucaggguucgacuccggagagcgggccugcgagacggcccgcacauccaaggacggcagcaggcgcggaacuugcccaaugcgcggcgcgcgaggcagcgacggggagcgcgcgagcgaggcgggcccacagcccccgccgcgcagccgagggcaaggucugugccagcagccgcgguaauuccagcucggcgagcgucgcgcggcgcugcugcaguugaaacgcccguaguuggccccccgccgccacgaggaaacgggagcgcuccaggcaggcccguuggccccgccgcgugggaccgcgcagcgggcgcggcgcgccgccgccgcagccccgaggagagcgggcgggggcaccgguaccggccggggacgggugaaacaggaugaucccgccgagaccgccggccgcgcaggcgccugccaagaccgccucugucaaucaagggcgaaggccgggggcuagaaggcgaucagacaccaccguauucccggccguaaacggugccgccccgcggccggcgcgcgcgucccgccggccgcccagggaaaccgggaggcuccgggcucuggggggaguauggccgcaaggcugaaacuugaaggcauugacggagggguaccaccagacguggagucugcggcucaaucugacucaacgcgcgcaccucaccaggcccggacgcgcggaggaccgacagccgggcgcgcuuucgcgaucgcgcgggugguggugcauggccgcucccagcccguggcgcgagccgucugcuccauugcgacaacgagcgagaccccggccgcgggcgccgcgggacggcccgcggcagcgggaggacggcggggcgauagcaggucugugaugcccucagacgcccugggccgcacgcgcgcuacacuggcggggccagccggcgcccgccaggacgcgcggagcccccgccguggccgggaccgcgggcuggaacgcccccgcgcaccaggaaugucuuguaggcgcccgcccccaccgcgcgccggacgcgucccugccccuuguacacaccgcccgucgcuccuaccgacugggcgcggcggcgagcgccccggacgcgcgaagggccgcgagcccccgcgccuggaggaaggagaagucguaacaagguauccguaggugaaccugcggauggauccuu ...<<<<<.[..(((>>>>>.<<<<<<<<<..<<<<<.........<<<.<<<..<<<.<<...........>>>>>......<<........<<<..<<..<<...<<<<..............<<.....<<<<<<....>>>>>>......>>........<<..<<<<...[.....<.....>..>>>>.>>..........>>>>..>>>>..>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>...<<<<<<<<....>>>>...>>>>.>>.<<<<<<..........>>>>>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>......>>>>>............<<<<<<.........>>>>>>.....<<<<<<<.........[.....((..>>)).......]....>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.......<<<.<<<<<<.......<<...<.......>............>>......>>>>>..>.>>>..<<<<<<.......]..>>>..>>>..........<<<<<<<.<...<<<<..<<..<<<<<.<<<..<..........>.....>>>.>>>>.>.>>.......<<....>>...>>>>..>.>>>>.>>>...>>>...>>>>...<<<<<<<<...<...<<.<.<.....>.>.>>...>>>>>>>>>.........<<<.<<..<<<<<<<<<<.<.....>.>>>>>>>>>>...<<..))>>....>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..)))..]<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<........<<........>>.........<<<<<......<<<<<<......<<..<<<.......>>>..>>....>>>>>>...<<.<<<.....<<<<<<....<<.<<<<<<....>>>....<<......>>....>>>.>>....<<<...<<<<<.....>>>>>.....<<<<<....>>>>>.........>>>....>>>.>>>.......>>>>>.......>>>>>......>>>>.>>>.....<<<.<<<.....<.<<<.<<....>>.>>>..>....>>>.>>>......<....<<.<<<<......>>>>.>>....>.....>>>>>>....<<<<<.<<.......>>.>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<<.<<....<<<<<<<<.<<<..<<<.<<<...........>>>.>>>..>>>.>>>>>>>>...>>.>>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>........ ...((((..[..[[..)))).(((((((((..(((((..((.....(((.(((..(((.((...........)))))......(((.......(((..((..((...((((..........(...((.....((((.(....).))))......))........(...((((...{.....(.....)..))))..).....)....))))..))))..))).(((....(((..((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((((((..........)))))).(.((....)).)...)))))).).....(.((....(((((...)))).).))).)...)))))...(..).....((((((.........)))))).....((((([[.........(.....((..]])).......)....)))))..)))))))))...[......((([....(.((((...(((.......(((.((((.........((........................))........)))..).)))..((((((.......}..))).).)).........((((((((.(...((((..(((..((((.((...(..........)......)).))))..))).......((....))...))))..).)))).)))..))))...))))....(((((.....(...((.(.........).))...)..)))))......{...(((.((..((((((.(((.(.....).))).))))))...((...]))....))...].))))))).(((......((((....))))....)))...]]..](((((.(((((((..((.((((((..(((.((((.(......((........)).........(((((.(....(((((.....(.((..(((.......)))..))...).)))))...((.(((...(.((((((....((.((((((....)))..(.((......)))...))).))....(((...((((((...))))))..(..(((((....))))).....)..).))....))).))).....).))))).....).)))))...)..)))).))).(....((..(.)......(((.((....)).)))...........)).......(.......((((......)))).......)..)..))))))....(((((.((.......)).)))))......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(((.(((...........))).)))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}....... Giardia Ribosome in PRE-T Hybrid State (D1); Small Subunit rRNA 8btd u 75 4.9 RF00005 URS0000326EAC_184922 36912103 0030533 0006412 184922 agcagaguggcgcagcggaagcgugcugggcccauaacccagaggucgauggaucgaaaccauccucugcuacca <<<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..(((.....[...))).(((((.......))))).......(((..]....)))..))))))).... Giardia Ribosome in PRE-T Hybrid State (D1); tRNA 8btd v 75 4.9 RF00005 URS00026813BC_184922 36912103 0030533 0006412 184922 agcagaguggcgcagcggaagcgugcugggcccucaacccagaggucgauggaucgaaaccauccucugcuacca ..<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<.<.........>.>>>>>>>...... ...((((...(((.......)))...((((.......)))).......((.(.......).)).))))....... Giardia Ribosome in PRE-T Hybrid State (D1); tRNA 8btd y 10 4.9 36912103 184922 aaaauggaga .......... .......... Giardia Ribosome in PRE-T Hybrid State (D1); mRNA 8btk B5 3764 3.5 RF02543 URS000231197F_9986 37170030 0003735 0005840 9986 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcgguggggcgcgggaaauguggcguacggaagacccacuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagngngaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcgugguccggccgugccggcggucucggcggaucuuucccgcuccccguuccuggggguggggucggcgggggaccgccccccggccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggccccggcggggaagguggcccggggggacgccucgccgccgucguccgcggcggcggcgggcgcgaccccuccccggguguuacagccccgccccggcagcagcagcucgccgaaucccggggccgagggagcgagaccugugucgccgcgcucuccccccucgggggggccgggccgccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgugucacgccgucgggcucgggggaggccacggcgcgucgcgcgccggcgcgcgcgcgcgagcgagcgcacggggucggcggcgaugucggcuacccacccgacccnucuugnaacncggaccaaggagunuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcggcggcgccgucgucggccgaggugggaucccgaggcccuuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccnanagauggugancuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauagnggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcaaccccgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcngaacuggcgnugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgcuggcagucggcagagcgagaaagagaguggagccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaunuuggugguagunnnaaauauucaaacgagaacuuugaaggccgaaguggngaaggguuccaugngaacagnanuugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucagccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccnuauccgcagcaggucuncaaggugaacngccucuggnauguuggaacaanguagguaagggaagucggcaagcnggauccguaacuucnggauaaggauuggcucuaagggcugguagcagccgacuuagaacuggugcggaccaggngaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugccnagugcucugaaugucanagugangaaauucaaugaagcgcggnuaaacggcgggaguancuaugacucucuuaagguagcnaanugccucnucaucuaauuagugangcgcaugaanggaugancgagnuucccacugunccuaccuacuauccagcgaaaccacngncaagggaacgggcuuggnggaaucagcggngaaagaagacccuguugagcuugacncuagucuggcacggugaanagacaugagagguguagaauaagugggaggcccgggccgccggugaaauaccacuacucuuaucguuuuuucacugacccggugaggcgggggggcgagccccgaggggcucucgcuucuggcgccaagcgccgggccccgucgguccgggccggcggcggccgggcgcgacccgcuccggggacagugccagguggggaguuugacugnggcgguacaccugucaaacgguancgcaggnnuccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucagnacgaauacagaccgugaaagcggggccucacgauccuucugagcuuuuggguuuuaagcaggangugucagaaaaguuaccacagngauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuungaugucggnucuuccuaucauugugaagcagaauucaccaagcguungaunnuucacccacuaauagggaacgugngcugggnuuagancgucgugagacagguuaguuuuacccuacugaugnuguguuguugccaugguanuccugcucaguacgagaggaaccgcagnuncanacauuugguguaunugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgaaggagccucgguuggccucggauagccggucccccgcgggguccggugcggagagcccuucgucccgggaaauggggcgcggccggaaagggggccgcccucucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>>..<<<<<<<<<....<<<<<<<<.<<<....<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>>>>>>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<.<....<<<<<<<<.<<<.....<<<<<<<<<<....<<<<<<<.<<<<<.<.....<<<<<.<<<..<<<<<<<<<<<<<<<..>>>>>>>>>..>>>>>>>>>>>>>>.>>>>>>>>>>...>>>.>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<.<<<<<<<<<<.<<<<...<<..<<<..<<<<<<<......<<<<<<<<<<....<<<<<<<<<<<<<<..>>>>>>>>>>>>>>........>>>>>>>>>>.......>>>>>>>..>>>.........>>>>>>...>>>>>>>>>>.....<<.....<<>>......<<<<<<.<<<<<<<.>>>>>>>.<<<<<<.<<<<.<<<<<<<<<.<<<<<<<<<<<<<<.<<<<....>>>>.>>>>>>>>>>>.>>>.>>>>>>.>>>...>>>>..>>>>.>><<<<<.<<<<<<<..>>>>>>>>>>>>....>>>>>>......>>.>>>>>....>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<<<<<<..>>>>>>>>>>>>..<<<<<...<<<..<<....((((.[[..>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<..........<<<.<<<<<<<<<...<<<....<<<..<.<<<..<<<<<<.<.....>.>>>>>>>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.........>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<.......>>...........]].))))..............>>>>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<<<<<...>>>>>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<...<<<<<<<....>>>>>>>...<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<...............<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<....>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<<..<<<<<<<..........<<<<<..<<<<..>>>>............>>>>>.>>>>>>>..>>>>>.>>>...<<<<<.....<<<<..<<.<<<<<<<..>>>>>>>>>..............<<<<<.<<<<.<<<<<<<<..>>>>>>>>..>>>>.>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>><<<<....>>>>>>)))].....<<<<<<<..<<<..)))))).>>>>>>>>>>.........>>>>..>>>>>>.......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<.]]]..>>>>..>>.>>...>>>>...>>>><<<<....<<<<<...........>>>>>....>>>>.>>>...>.>>>>>>.....<<<<<<<..<<..<<<<....<<<........<<<<<..<<<<..>>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<........>>>>>>>>>>...>>>>..>>>..............>>>>..>>>>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<.<..<<<<<......>>>>>..>>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..(((((((((((.....)))))).))))....))))....(((((((((....((((((((.((.....((((((((..({((((......)))))....[[(...).(((....}]])))...).))))))).))))))))))...)))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....((((((((((.(..(((((((.(((((.((....(((((.(((..(((((((.(((((((()))))))).)..)))))))))))))))))))))))))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((..(((((((......((((((((((...((((((((((((((....))))))))))))).)......)))))))))).......)))))))..))).........))))))..))))))))))).....((.....{{))......((((((.(((((((.))))))).((((((.((((.(((((((((.((((((((((((((.((((....)))).))))))))))).))).)))))).)))...))))..)))).))(((((.(((((((()))))))))))))..[.)))))).....))).)))))...)))))...)))))))).<((((........))))((((((....(((((((((((((..(((..(((((........))))..)..)))...((....))...((((((((((((()))))))))))))..(((((...(((..((.(].[[[[.[[[)))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......B)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((..........(((.((((((((.....((.....((.....((...((((...........)))).)).....))...))......))))))...(((((((((.(......))))))))))....))))))))))))..))..((((..(.((.....)).)..))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.....A.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((.......}}.........].]].]]]].(...)........)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((..(((((((...((.....)).))))))....[[(((.((...(.....(((....)))...(.)....((.(((((((((...))))))))))).......)....))...(((((........)))))]]((((....(((((...((.((((....)))).))..((((....)))...(...((((((...((((((((((((((((((((((...{{{...)))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).))).))).....((......)).)))).((((.....))))..)))....(((......((((((..((..(....(.......(((((....(.[..).....)))))((.(((((((((((....)))))..)))))).))(...).......(((((((((.>.(...........)...(((((((....((((.....))))......))))))).].(.(.(((..((((((.....(......((.(....).))......)..))))..)))))(.(.(.........).).)........((..........(((((.......)))))..)..)....).)....)).))))))).)..)))..))))))...)))))....)).[..((.((.....>].)).))....(((((..(((.((......((((.(((((...(((((.(((((((((.((((((((..((((..(.......[..(((((..((((()))))..........].))))).)..))))..))))).)))...(((((.....((((..((.(((((((..)))))))))..............(((((.((((.((((((((()))))))))..)))).)))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(..((.(..((....{..))...))).)(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}.....)))..)))))).......(....(.((((.(...((.......))...).))))...)....)........((((.((((((..(.(.(.(((......))).)...).).(((.(.....).))).....)))))..)...))).)......((((((....))).)))...b.))..))).))))).....(.((.(.(..(((..(.(((((......(....).....))))).)(((.....((((....((.(((((((}}}.)))))..)).))...))))....))).((((...((((.....a.......))))...))))..)))...).).)).).....((((((...((..((((.(..(((.........((((..((((())))).))))........)))...(((..((((....((((.((((((........))))))))))...))))..)))...........)..))))..)).))))))(((((....(.......).......((.(((((((.((.....(.((.(..(((((......)))))..))).)....))....)))).))).))..))))).. Structure of the TRAP complex with the Sec translocon and a translating ribosome; 28S rRNA 8btk B7 119 3.5 RF00001 URS000002B0D5_9986 37170030 0003735 0005840 9986 ucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>... ((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))... Structure of the TRAP complex with the Sec translocon and a translating ribosome; 5S rRNA 8btk B8 156 3.5 RF00002,RF02540 URS00023119A4_9986 37170030 0003735 0005840 9986 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauuncaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<.<<.....>>>.....(.<<<......>>.............>>>..)...>>>....<<....>><<<<<<<<.......>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))(((((((((.....))))))))).................... Structure of the TRAP complex with the Sec translocon and a translating ribosome; 5.8S rRNA 8btk A2 1770 3.5 RF01960,RF02542,RF01959,RF00177 URS00023119C9_9986 37170030 0003735 0005840 9986 uaccugguugauccugccaguagcaunugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucnuuaaaucaguuauggunccuunggucgcucguacuuggauaacugugguanuucuagngcuaananaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucagaucaaaaccaacccggugccggcggcuuuggugacucuagauaaccucgggccgaucgcacgcccuccguggcggcgacgacccauucgaacgucngcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgaunccggaganggagccugagaaacggcuaccacauncaaggnaggcagcaggcgcgcnaauuacccacucccgacccggggangungugangaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaanuccuuuaacgaggnuccauuggagngcaagucuggugccagcagccgcggnaauuccagcuccaauancguauauuaaaguugcugcaguunaaaagcucguaguungaucuugggagcgggcggccgcccguccccgccucucggcgccccggggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaaungaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagancgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacncaacacgggaaaccucacccggcccggacacggacagganugacagauugauagcucuuucucgauuccguggguggngnugcauggcnguucuuaguugguggagcgauuugucugguuaauuccgauaacgancgagacunuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuncuuanagggacaaguggcguucagccacccgagauugagcaauaacangucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgagnaauucccaguaagugcgggucauaagcuugcguugauunagucccugcccuuuguacacaccgnccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggucggcccacggcccuggcggagcgcugagaagacggucgaacungacuaucuagaggaaguaaaagucguancaagguuucnguaggugnnccugcggaaggaucauua ...<<<<<...[[[[>>>>>[[[.((((((.....{{.........[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[......{{....[[[[[.........<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<<<....>>>>>>...>>>>[[..(((((.....<<<<<<<<<<<<<..>>>>.......<......>..)))))......]]...<<<<.<<<<......>>>>>>>>.]].]]]...}}....]]].<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<<...>>>>..>>>......}}.......<<<<<<<<<.<<<....>>>..>>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..)))))).]]]............{{.......{{...[[[.[[....<<<.<<<<<<<..>>>>>>>.>>><<...<<<..<<<<..>>>>.>>>.>>..<<<<<<.<.......<<...<.......>.<<<<.......>>>>...>>......>.>>>..>>>........{.[[.(((((((.....>>>>>>>>>.))))))).]].}....]]....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<..}}>>...>>.....>>>.....<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<........<<........>>..........<<<<<......<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<<<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<.......>>>>.>>>>.....>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>...>.>>>>>>>.......>>>>>......>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<<<<<<<<<<<<<<.....>>>>>>>>>>>>.>.>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))((...(((((......(..((.....(((.(((..((....((....((..........))...)){))......(((.......(((.(....((....(((.....(({...((.....((.(((.....))).))......))......)).((((...(((((......)))))...))))((..(((((.....[[.[[[[[[.(((())))........(......)..)))))......)).(}((((.((((......)))))))))...)))...))..).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)...)........(((((((((.(((....)))..)))))).)))....(.((..(...........)..))......)..((((([[....(.(.((.....((..]])).......)).)))))))..)))))...))..{......(.({{...(.(.((...(.(..(....(((.(((((((()))))))).)))((.....(..((((())))).)...))..(..(((..........(..((.......)).((((...)..)))....).........)))....)........(.((.(((((((.....]]]]]].]].))))))).)).)....)....(((..(...(...(((...((..((((((((...(..........)......))))))))..)).......((....))....)))..)...)...))..)).)...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..(.((((((.(((((....))))))))))).)..)))...((..}}))...))...}.))))).).(((......((.(....).))....)))...]]].]((((..(((((((..((..((.((..(((..(((((.......(........)...........(((((.(....(((((.....(..(..(((........)))..)....).)))))...((.(((...(.((((((....((..(((((....)))..(.((......)))...))..))....(((...(...((.(..((((.((((((((....).)))).)))......))))..).))..).....(((((.....)))))........)))....))).))).....).))))).....).)))))...)).)))..))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....((((............)))).....)..)..)).)).....((((((((.......))))))))......))...))))))).)).))..(.(..((.(..((((.((..(.((((((((.(((..((((.((...((((((.((.((((((((.....)))))))).))..).)))))...)).))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>........ Structure of the TRAP complex with the Sec translocon and a translating ribosome; 18S rRNA 8btk AT 75 3.5 RF00005 URS0002681408_9986 37170030 0030533 0006412 9986 gccgugaucguauagugguuaguacucugcguuguggccgcagcaacnucggnucgaauccgagucacggcacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>....<<<<<.......>>>>>>>>>>>>.... (((((((...(((....[...)))..(((((.......)))))....(((((..]....)))))))))))).... Structure of the TRAP complex with the Sec translocon and a translating ribosome; P-site tRNA 8btr LD 142 3.25 RF00002 URS000268138A_184922 36912103 0003735 0005840 184922 gcacgccccgccggcggaugccucggcccgggcggcgacgaagagcgcggcggagcgcgagacgcggugcggacccgcccgccccgagaagcaccgauccucgaacgcagcgcgccccggcgccgccgccucggcgccugcc ..........................................<<<<<<<((....>>>>.....<<<<<<...<..))..>.........>>>>>>...>>>....<<...>><<....>>..................... ..........................................((((((.[[.....))).....((((((...(..]]..).........))))))...)))....((...))((....))..................... Giardia Ribosome in PRE-T Hybrid State (D2); 5.8S rRNA 8btr LE 117 3.25 RF00001 URS00026813A5_184922 36912103 0003735 0005840 184922 aguucggccauccuacggcggaaacuccuuaacucguuccgaauuaggaagagaagcgccgucaggccccgccaguacugcgaucggagacgucgugggaacacggggugccgaacu <<<<<<<<....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>><<<<<<......<<<<<<.<<....>>>>>>>>.....>>>>>>>>>>>>>> ((((((((....((((((((.....((((((...(.....)...))))..))....)))))).))((((((......((((((.((....)))))))).....)))))))))))))) Giardia Ribosome in PRE-T Hybrid State (D2); 5S rRNA 8btr Lt 2593 3.25 RF02543 URS0002681395_184922 36912103 0003735 0005840 184922 ggcgggccugaggcggcgggggcgacgggcggaacuuaagcauaucaguacgccccggaggagaaaccaaccgggauuccccgcuagcggcgagcgacgcgggaggagcccgccccgaaggcgcgcuguggggccgcgagggggcccgagggccccgcccgagagggugcaagccccguacggcgaguagcgcugcuugagcgugcagcgcgaagggaggcgcggcccuuccaaggcuaaauacgccccgggaccgauagcggaccaaguagcgcgagcgaacggugaaaaggacgcccugcggccgcucaaaagaccugaacccggccggccgccggcccgccggccccgucucgaaacacggaccgaggagccacgcgccgcggcgagcccgagggagcccccgcggcggagcgagcgcgagacgccccgggcccgccaugccccugcgggcgugcgcgggccgagccgcggcgcgugggcccgaaaggcggugaucuaugcccggcgagggcgaggccgggcgaaagccugguggaggcccgccgcggugcugacgcgcagaucgcucgucggagccgggcaugggggcgaaagacucaucgaaccgccugguagcugguugccuccgaaaugucucccaggacagccgccgccccgcaguugcggcccguagagcgcuggccggcgggagcggggggccugccccucgcccgccccccaaacuccgaagggccgcgccgccccgccgcuggccugggcggggcgggcgaaugcgggcggcgcgugggccccuccugguaagcaggacgggcgaggcgggacgauccggacgccgggccagggugcgccgccggggcccgcggaacggcgucggccggucccgacagccgaaucggccggcccggaaaauggagcgcgccggagccccggacccgcgcccggccgccgcgcgcggcggguaggaggccgcagaggccccgggggcgaaggcggcgcgcaggccccgccggaccggccucuggugcagaucucggcagcaguagccgcuacuccgcgccccggaggacugagggggagacggguuccgcggcgccugcaucuggccgcgggugacucgggccuaagcggcgggugaagaccgggaaggggcgcccgcccgucgaacggggagccggcggagacuccggcaggcgcggcccccgcggagacgcccgccccccggcgacgcgcacggggaccgcggcgggcggcgccccggcccgcgaacgccccgcagcccccggacgccuugcgcggagaggggggcccgggggcggaccgcgcguccccggccgccccugaaaagccggggggcgccggccgcgcgccguaccgaccgcagcaggacuccggggucagcagccucuagcgcgggagcgaacgcggcucagggaagucggcaagccggcuccguaaccucgggaaaaggaguggcucugacggcgccgggucagaacuggaacggacgcggggaucccgacuguuuacuagaaacacagcgucgcgagggccgcacccggcgcuggcgcgacgugauuucugcccagugccacgaccgucaccgugaagcgauccgccgaagcccugguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucgggcaauuuccgacgugcaugaauggaccaacgaggaucccacugucccgagccgcgccuccgcgagccuccagccucgggaacgggcgagggccggccagcggggcaagaagacccuuuugagcuugacuccagcccgggccuguggggcggggcggccggcgcagcgcacaggggaggccgcgccccugagacacccugacggccgccgccgccccgcucacccggucgcgcggggacccgcccgggcggggaguucggcuggggcggcgcgccugcuacaccggaccgcaggcgucccacggcgggcucagcgaggacggagaccucccgcggagcagaagggcacaagcccgcccgacccgcgccccccgugccggcgcgggccgcgaaagcggggccuaccgauccuucgccgccccggccgcgggcgcggagguggcagaaaaguuaccacagggauaacuggcuuguggccgccgagcgcccgcagcgacgcggcuuuuugauccuucgaugucggcucuuccuaccguccgcgcgcaccggcgcggaagcgucggauuguucacccguucaagggaucgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacuggccccggggccagagcacggcgggccaguacgagaggaacgcccgccgcgggccgccagccccgcgguugcccggccgggcagcgccgcgccgccgcgcccgggggcccugcgcugaccgccucuaagcgcgcaccccgccucgcgccccgcccggccgcgcgccccagccccgugccccgucgccgagcggcccccgcccggggagaccacccggcgcggcgcuccuguacggcgcagagcccugcgaucgccugagggacgcgccugcagagcgcgg .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<.....<<.....>>.....>>>>>..[[[...<<<.............>>><<<<....<<<<<......>>>>>((......<<<.....))>>>...>>>>.....<<<<<<<........>>>>>>>...(((((..<<<<<<)))))..]]]..................................<<....>>................<<<....>>>............................<<<<<<..>>>>>>.<<<<........>>>>.<<<<<....<<<<<<<<<<<<<..<<<...<<<....>>>..>>>...<<....>>............<<<<<<<<<<<<<....>>>>>>>.>>>>>>...>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<<.<<<.<<<<<<<<<...<<<...<<<..<<<<<<..<<<<<........>>>>>>>>>>>..>>>..>>.>...>>>>>>>.<<<<<<<<<<.........>>>>>>>>>>...>>>>>>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((...<<<<<<<........<<<.<<<<<<<<<..............>>>>>>>>>>>>..........)))......>>>>>>>>>>>..>>>>>>><<<<<....>>>>>....>>>>>><.<<<<<<<<...<<......<<<<<.<<....>>.>>>>>...>>>>>>>>>>..>.....>>>>>.<<.....<<.....<<<<<.....>>>>>..<<.....<<<<..<<...<<<<<<...<.......>.>>>>>>....((<<<.<<...<<<...<<<....>>>......<<....>>...>>.>....>>...<<<<<........>>>>>))<<<<<<<<...<<<....>>>..<<<<<<<<<<...<<<..<<<<<<<<<<<<<<<<<...{{{...>>>>>....<<<<<<...<<<<<<....<<.....>>......>>>>>>...>>>>>>..>>>>>.>>>>>>>..>>>.........>>>>>>>>>>...>>>>>>>>.>>>..>>..<<......>>.>>>>.<<<<.....>>>>..>>....<<<<....<<<<<<<<.<<...............<<<<<....<....>.....>>>>><<.<<<<<<<....>>..>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<....>>>>......>>>>>>>...<<..<<<..<<<<<<.<...<<....<<<.<....>.>>>....>>.>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>....>>.(..<<<<<......).>>>>>...((((((..{{{.........{{{..{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<<<<<<<<<..........<<<<<....................>>>>>.>>>>>>>>.>>>>>>>>>...<<<<......>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<.<<<<.......>>>>.>.....<<...(((>>....>>>>>>>...<<<<<<<<.........>>>>>>>>.<<<....>>>.>>))).......(((((.(((((.>>>>>>))))))))))..........]]]]..}}.}}}.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<.........>>>....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........}}}.))))))..<<<<<..<<<..<<<<<<<<...............>>>>>>>><<<<<...<.<<...<<<<<<<<<<}}}.>>>>>..>>>>>...>>.>.>>>>>.<<<...<<<<<<...........>>>>>>...>>>..>>>..>>>>>....<<<<<<............................>>>>>>...<<.<<<<.......>>>>..<<<<<<<<<<<....<<<<....<<...>>...>>>>...>>>>.>>>>>.>>.....>>.. .........................((((((.....(...[..)......))))).).........((....))...((((.....((.]...)).....))))...((((..(((...(...).....)))(((......((((......)))).[[(...).(((.....]])))....))))....(((((((........)))))))...(((((..[[[[[[)))))..)))..................................((....))............(...(((....)))...........)................((((((..))))))<((((........)))).(((((....(((((((((((((..((....(((....)))...))...((....))....(......)(((((((((((((....))))))).))))))...)))))))))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......A)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(((((....)))))((((((((((.(((.(((((((((...(((...(((..((((((..((((..........))))))))))..)))..)).)...))))))).((((((((((.........))))))))))...))))))))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(((((((........(((.(.((((((((............)))))))).))))..........]]]......))))))))))...)))))))(((((....)))))....))))))(.((((((((...((......(((((.((....)).)))))...))))))))))..).....))))).((.....((.....(((((.....)))))..((.....((((..((..(((((((...(.......).))))))....[[(((.((...(((...(((....))).(....(......).).)).)....))...(((((........)))))]]((((((((...((......))...(((((((((...(((..(((((((((((((((((...{{{...)))))....((((((...((((((....((.....))......))))))...))))))..))))).)))))))..)))(...)....)))))))))....)))))))).))).)))..((......)).)))).((((.....))))..))....((((....((((((((.((..(....(.......(((((....(.{..).....)))))((.((((((........)))))).))(...).......(((((((((.].((.........))...(((((((....(((......)))......))))))).}.(((.(((..((((((.(...((....(((.(....).)))....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....))[[..(((((.....>]])))))...((((((..(((.((......(((..((((((..(((((.((((((((..((((((((((((.((((..........((((...(....).............)))).)))).))).)))))))))...((((......)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.(.((((.......)))).)...).((][.[[[))....)))))))...((((((((.....{...)))))))).(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....)}....))))..)).))).......(..(.(.((((((...((.......))...))))))...))...)........((((.((((((..(((((((((......))))))..))).(((.(.....).)))....)))))..)...))).).....(((((((....))).))))..a.))..))).))))))..(((((..(((..((((((((.....(....)....))))))))(((((...(.((...((((((((((}}}.)))))..)))))...)).).))))).(((....((((.............))))....)))..)))..)))))....((((((........(..)................))))))...((.((((.......))))..(((((((((((....((((.(..((...))..)))))...)))).))))).)).....)).. Giardia Ribosome in PRE-T Hybrid State (D2); Large Subunit rRNA 8btr St 1454 3.25 RF01960,RF02542,RF01959,RF00177 URS00026813B3_184922 36912103 0003735 0005840 184922 cauccggucgauccugccggagcgcgacgcucuccccaaggacgaagccaugcaugcccgcucacccgggacgcggcggacggcucaggacaacgguugcaccccccgcggcggucccugcuagccggacaccgcuggcaacccggcgccaagacgugcgcgcacgggcgcgcgccccgcgggcgagcagcgugacgcagcgacggcccgcccgggcuuccggggcaucacccggucggcgcggucgcggcgcgccgagggcccgacgccuggcggagaaucaggguucgacuccggagagcgggccugcgagacggcccgcacauccaaggacggcagcaggcgcggaacuugcccaaugcgcggcgcgcgaggcagcgacggggagcgcgcgagcgaggcgggcccacagcccccgccgcgcagccgagggcaaggucugugccagcagccgcgguaauuccagcucggcgagcgucgcgcggcgcugcugcaguugaaacgcccguaguuggccccccgccgccacgaggaaacgggagcgcuccaggcaggcccguuggccccgccgcgugggaccgcgcagcgggcgcggcgcgccgccgccgcagccccgaggagagcgggcgggggcaccgguaccggccggggacgggugaaacaggaugaucccgccgagaccgccggccgcgcaggcgccugccaagaccgccucugucaaucaagggcgaaggccgggggcuagaaggcgaucagacaccaccguauucccggccguaaacggugccgccccgcggccggcgcgcgcgucccgccggccgcccagggaaaccgggaggcuccgggcucuggggggaguauggccgcaaggcugaaacuugaaggcauugacggagggguaccaccagacguggagucugcggcucaaucugacucaacgcgcgcaccucaccaggcccggacgcgcggaggaccgacagccgggcgcgcuuucgcgaucgcgcgggugguggugcauggccgcucccagcccguggcgcgagccgucugcuccauugcgacaacgagcgagaccccggccgcgggcgccgcgggacggcccgcggcagcgggaggacggcggggcgauagcaggucugugaugcccucagacgcccugggccgcacgcgcgcuacacuggcggggccagccggcgcccgccaggacgcgcggagcccccgccguggccgggaccgcgggcuggaacgcccccgcgcaccaggaaugucuuguaggcgcccgcccccaccgcgcgccggacgcgucccugccccuuguacacaccgcccgucgcuccuaccgacugggcgcggcggcgagcgccccggacgcgcgaagggccgcgagcccccgcgccuggaggaaggagaagucguaacaagguauccguaggugaaccugcggauggauccuu ...<<<<<.[..(((>>>>>.<<<<<<<<<..<<<<<..<......<<<.<<<..<<<.<<...........>>>>>......<<........<<<..<<..<<...<<<<..............<<.....<<<<<<....>>>>>>......>>........<.<.<<<<...[.....<.....>..>>>>.>>..........>>>>..>>>>..>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>...<<<<<<<<....>>>>...>>>>.>>.<<<<<<..........>>>>>>.<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>..>>>..>...>>>>>............<<<<<<.........>>>>>>.....<<<<<<<......[........((..>>))..........].>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.......<<<.<<<<<<.......<<..<<.......>>...........>>......>>>>>..>.>>>..<<<<<<.......]..>>>..>>>..........<<<<<<.<....<<<...<<..<<<<<.<<<..<.<......>.>.....>>>.>>>>.>.>>.......<<....>>....>>>....>>>>.>>>...>>>...>>>>...<<<<<<<<...<...<<.<.........>.>>...>>>>>>>>>.........<<<.<<..<<<<<<<<<<.........>>>>>>>>>>...<<..))>>....>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..)))..]<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>.........<<<<<.<....<<<<<<......<<<.<<<.......>>>.>>>....>>>>>>...<<.<<<..<<.<<<<<<....<<.<<<<<<....>>>....<<......>>....>>>.>>....<<<<..<<<<<<...>>>>>>.....<<<<<....>>>>>........>>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<<.......<<<.<<....>>.>>>.......>>>>>>>...........<<.<<<<......>>>>.>>..........>>>>>>....<<<<<.<<.......>>.>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<<.<<....<<<<<<<<.<<<..<<<.<<<...........>>>.>>>..>>>.>>>>>>>>...>>.>>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>........ ...((((..[..[[..)))).(((((((((..(((((..((.....(((.(((..(((.((...........)))))......(((.......(((..((..((...((((..........(...((.....((((((....))))))......))...(........((((...{.....(.....)..))))......).)....))))..))))..))).(((....(((..((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((((((..........)))))).(.((....)).)...)))))).).....(.(((...(((((...)))).))))).)...))))).............(((((.........)))))......((((([[.........(.....((..]])).......)....)))))..)))))))))...[......((([[...(.((((...(((........((.((((((.......((..((.......))...........))......)))))..).))....(((((.......}..))).).)..........((((((((.(...(((...((...((((.((...(..........)......)).))))...)).......((....))....)))..).)))).)))..))))...))))....((((((....(...((.(.........).))...).))))))......{...(((.((..((((((.(((.(.....).))).))))))...((..]]))....))...].))))))).(((......((((....))))....)))...]]..](((((.(((((((..((..(((((..(((.((((((......((........)).........(((((......(((((.....(.(((.(((.......))).)))...).)))))...((..((...(.((((((....((.((((((....)))..(.((......)))...))).))....((....(((((.....)))))..(..(((((....))))).....)....))....))).))).....).)).)).......)))))...)).)))).))).(...(.((((........(((.((....)).)))........)))).)......(....((.((((......)))).))....)..)..))))).....(((((.((.......)).)))))......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(((.(((...........))).)))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}....... Giardia Ribosome in PRE-T Hybrid State (D2); Small Subunit rRNA 8btr u 75 3.25 RF00005 URS0000326EAC_184922 36912103 0030533 0006412 184922 agcagaguggcgcagcggaagcgugcugggcccauaacccagaggucgauggaucgaaaccauccucugcuacca <<<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..(((.....[...))).(((((.......))))).....(((((..]....)))))))))))).... Giardia Ribosome in PRE-T Hybrid State (D2); tRNA 8btr v 75 3.25 RF00005 URS00026813BC_184922 36912103 0030533 0006412 184922 agcagaguggcgcagcggaagcgugcugggcccucaacccagaggucgauggaucgaaaccauccucugcuacca <<<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... .((((((..((((....[..))))..((((.......))))......(((((..]....)))))))))))..... Giardia Ribosome in PRE-T Hybrid State (D2); tRNA 8btr y 11 3.25 36912103 184922 aaaauggagaa ........... ........... Giardia Ribosome in PRE-T Hybrid State (D2); mRNA 8buu A 2852 2.9 RF02541 URS00026813E0_224308 36951104 0003735 0005840 224308 uuaaguuagaaagggcgcacgguggaugccuuggcacuaggagccgaugaaggacgggacgaacaccgauaugcuucggggagcuguaagcaagcuuugauccggagauuuccgaauggggaaacccaccacucguaauggagugguauccauaucugaauucauaggauaugagaaggcagacccggggaacugaaacaucuaaguacccggaggaagagaaagcaaaugcgauucccugaguagcggcgagcgaaacgggauuagcccaaaccaagaggcuugccucuugggguuguaggacacucuguacggaguuacaaaggaacgagguagaugaagaggucuggaaaggcccgccauaggagguaacagcccuguagucaaaacuucguucucuccugaguggauccugaguacggcggaacacgugaaauuccgucggaauccgggaggaccaucucccaaggcuaaauacucccuagugaccgauagugaaccaguaccgugagggaaaggugaaaagcaccccggaaggggagugaaagagauccugaaaccgugugccuacaaguagucagagcccguuaacgggugauggcgugccuuuuguagaaugaaccggcgaguuacgaucccgugcaagguuaagcagaagaugcggagccgcagcgaaagcgagucugaauagggcgcaugaguacguggucguagacccgaaaccaggugaucuacccauguccagggugaaguucagguaacacugaauggaggcccgaacccacgcacguugaaaagugcggggaugagguguggguaggggugaaaugccaaucgaaccuggagauagcugguucucuccgaaauagcuuuagggcuagccucaagguaagagucuuggagguagagcacugauuggacuaggggccgguuaccgaauucagucaaacuccgaaugccaaugacuuauccuugggagucagacugcgagugauaagauccguagucgaaagggaaacagcccagaccgccagcuaaggucccaaaguauacguuaaguggaaaaggauguggaguugcuuagacaacuggucgagugacucugcgccgaaaauguaccggggcuaaacguaucaccgaagcugcggacuguucgaacagugguaggagagcguucuaagggcugugaagccagaccggaaggacugguggagcgcuuagaagugagaaugccgguaugaguagcgaaagaggggugagaauccccuccaccgaaugccuaagguuuccugaggaaggcucguccgcucaggguuagucgggaccuaagccgaggccgaaaggcguaggcgauggacaacagguugauauuccuguaccaccuccucaccauuugagcaauggggggacgcaggaggauaggguaagcgcgguauuggauauccgcguccaagcaguuaggcugggaaauaggcaaauccguuucccauaaggcugagcugugauggcgagcgagcgaaguuccugauuccacacugccaagaaaagccucuagcgaggugagaggugcccguaccgcaaaccgacacagguaggcgaggagagaauccuaaggugaucgagagaacucucguuaaggaacucggcaaaaugaccccguaacuucgggagaaggggugcucuguuagggugcaagcccgagagagccgcagugaauaggcccaggcgacuguuuagcaaaaacacaggucucugcgaagccguaaggcgaaguauaggggcugacgccugcccggugcuggaagguuaagaggagcgcuuagcguaagcgaaggugcgaauugaagccccaguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgacccgcacgaaaggcgcaacgaucugggcacugucucaacgagagacucggugaaauuauaguaccugugaagaugcagguuacccgcgacaggacggaaagaccccguggagcuuuacugcagccugauauugaauguugguacagcuuguacaggauagguaggagccuuggaaaccggagcgccagcuucgguggaggcaucggugggauacuacccuggcuguauugaccuucuaacccgccgcccuuaucgggcggggagacagugucaggugggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguucccucagaaugguuggaaaucauucgcagaguguaaaggcacaagggagcuugacugcgagaccuacaagucgagcagggacgaaagucgggcuuagugauccggugguuccgcauggaagggccaucgcucaacggauaaaagcuaccccggggauaacaggcuuaucucccccaagaguccacaucgacggggagguuuggcaccucgaugucggcucaucgcauccuggggcuguagucagucccaaggguugggcuguucgcccauuaaagcgguacgcgagcuggguucagaacgucgugagacaguucggucccuauccgucgcgggcgcaggaaauuugagaggagcuguccuuaguacgagaggaccgggauggacgcaccgcugguguaccaguuguucugccaagggcaucgcuggguagcuaugugcggacgggauaagugcugaaagcaucuaagcaugaagccccccucaagaugagauuucccauuccgcaaggaaguaagaucccugaaagaugaucagguugauaggucugagguggaaguguggcgacacauggagcugacagauacuaaucgaucgaggacuuaac <<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<..[..((.>>>.....<<<<<<<..<<<))..]..>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<<<<<<<<.........>>>>>>>.>>.>>....<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<......<<.....>>.....>>>>...(((....<<<<<<<<....>>>>>>>>......<<<<<<<<<.....<<<<.......<<<<<<<<<<.<<<.....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>.>>>>>..>>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<....>>>>..................>>>>>>>>>>>.......<<<<..<<<<......>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<.<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>......>>>>>.>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<...<<<<<<<<<.....<<<...<<<<<<<<...<<.<<..>>..>>...>>>>>>>>..>>.>.....>>>>.>>>>>..>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<..>>....>>>>>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<..>>>>>>....>>>>>>..<<<<<<<.<<......<<<<<.<<....>>.>>>>>...>>.>>>>>>>........>>>>>><......<<....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<.<<<<<<......<<...<<<<....<<<<..<<<..<<<.<<<<<<<<...(((....>>>>>><<..<<<<<..<<<<<<<<<<<.<<.....>>>>>>>>>....>>>>..>>>>>...>><..<<..>>...>>>>>>...>>>...>>>>.........>>>>..>>..>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<....<<<<....>>>>...>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>..<<<<.<<<..<<<<<<<..<<<...<<...<<<<<..<<....>>...>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>...>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<<.<<<.<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>.>>>....<<.<<<<<<.....>>>>>>>>.....>>>>>>>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.)))>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>. ((((((......((((((((((.....(((..(((((((((((((......((((((..[..[[[)))...].((((((...(((]]..]..)))......))))))...)))....(((....)))(((((((......))))))).(((((((((.........))))))).)).))....((((((.....(...[..)......))))).).........((....))...((((......((.]...)).....))))...((((...((((((((....))))))))....{.(((((((((.....((((.......((((((((((.(((...(.((((......)))))[[(...).(((.....]])))...)))...)))))))))))))).)))))..)))))....((((((((..[......))))))))....}.(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((..((((..[...))))..)))).<.(.(........).).((((((....(((((((.(((((..(((...(((.....)))...)))...((....))..((((.....))))......))))).)))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)<)))...(((.(((((.......A))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((..((((((((((.....(((...((((((((...((..(..)...))...))))))))..)).).....)))).))))).)))))))).))..(((((((.((......)).)))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.((..))...)))))))))).))...........]]].)...))))))))))...)))))))((((((()))))))....))))))(.(((((((.((......(((((.((....))])))))...)).)))))))..).....))))))(......((....((((((.......))))))((((....(((...((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((.((((((......((...((((....((((..(((..(((.(((((((((...{{..).))))))((..(((((..(((((((((((.((.....)))))))))....))))..)))))...))(..((..))...))))))...)))...))))(..).....))))..))..))))))))))))))).))).....((......))..))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.[..).....)))))(((((....((((....))))...)))))(...).......(((((((((.>.((.........))...(((((((.....(((....))).......))))))).]((((.(((..(((((((..(((...((...(((((..((....))...)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).[..(((((.....>].)))))..((((((((.(((.((......((((.((((((..(((((.(((((((((.(((.((((((((((((.(......[..(((((..(((......((((.(((....))).))))...)))..........].)))))).)))))))))))).)))....((.((((((.....)))))))).....)))))))))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))..a.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((....))))....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))...))))))). ARE-ABCF VmlR2 bound to a 70S ribosome; 23S rRNA 8buu B 112 2.9 RF00001 URS00001CC3E3_224308 36951104 0003735 0005840 224308 ugguggcgauagcgaagaggucacacccguucccauaccgaacacggaaguuaagcucuucagcgccgaugguagucggggguuucccccugugagaguaggacgccgccaa <<<<<<<....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<.......<<.<<<<<...>>>>>.>>.......>>..>>>>>>>. (((((((....((((((((.....((((((...(.....)...))))..))....)))))).)).((.......((.(((((...))))).)).......))..))))))). ARE-ABCF VmlR2 bound to a 70S ribosome; 5S rRNA 8buu V 73 2.9 RF00005 URS00004A5E97_224308 36951104 0030533 0006412 224308 gcgggguggagcaguucgguagcucgucgggcucauaacccgaaggucgcagguucaaauccugcccccgcaa <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>.. ((((((..((((......[..)))).(((((.......))))).....(((((..]....))))))))))).. ARE-ABCF VmlR2 bound to a 70S ribosome; tRNA-fMet 8buu a 1538 2.9 RF01959,RF00177,RF02542,RF01960 URS00001B4049_224308 36951104 0003735 0005840 224308 ggagaguuugauccuggcucaggacgaacgcuggcggcgugccuaauacaugcaagucgagcggacagaugggagcuugcucccugauguuagcggcggacgggugaguaacacguggguaaccugccuguaagacugggauaacuccgggaaaccggggcuaauaccggaugguuguuugaaccgcaugguucaaacauaaaagguggcuucggcuaccacuuacagauggacccgcggcgcauuagcuaguuggugagguaacggcucaccaaggcgacgaugcguagccgaccugagagggugaucggccacacugggacugagacacggcccagacuccuacgggaggcagcaguagggaaucuuccgcaauggacgaaagucugacggagcaacgccgcgugagugaugaagguuuucggaucguaaagcucuguuguuagggaagaacaaguaccguucgaauagggcgguaccuugacgguaccuaaccagaaagccacggcuaacuacgugccagcagccgcgguaauacguagguggcaagcguuguccggaauuauugggcguaaagggcucgcaggcgguuucuuaagucugaugugaaagcccccggcucaaccggggagggucauuggaaacuggggaacuugagugcagaagaggagaguggaauuccacguguagcggugaaaugcguagagauguggaggaacaccaguggcgaaggcgacucucuggucuguaacugacgcugaggagcgaaagcguggggagcgaacaggauuagauacccugguaguccacgccguaaacgaugagugcuaaguguuaggggguuuccgccccuuagugcugcagcuaacgcauuaagcacuccgccuggggaguacggucgcaagacugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggucuugacauccucugacaauccuagagauaggacgucccggggcagagugacagguggugcaugguugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuugaucuuaguugccagcauucaguugggcacucuaaggugacugccggugacaaaccggaggaagguggggaugacgucaaaucaucaugccccuuaugaccugggcuacacacgugcuacaauggacagaacaaagggcagcgaaaccgcgagguuaagccaaucccacaaaucuguucucaguucggaucgcagucugcaacucgacugcgugaagcuggaaucgcuaguaaucgcggaucagcaugccgcggugaauacguucccgggccuuguacacaccgcccgucacaccacgagaguuuguaacacccgaagucggugagguaaccuuuuaggagccagccgccgaaggugggacagaugauuggggugaagucguaacaagguagccguaucggaaggugcggcuggaucaccuccu ...<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<<<...<<<..<..>..>>>...>>>>.>>>>>......<<........<<<<<<<..<<...<<<<<<<.<<<<.....<<<<<<....>>>>>>......>>>>.....<<<<<<<<<<....>>>>>>>>>>.....<<<<<<....>>>>>>.>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<<<<<<<.........<<<<<<<<<.....>>>>>>>>>..........>>>>>>...>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<.......<<<<<<.....>>>>>>.....>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<......>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<....<<<<<....>>>>>...<<<.>>>>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<......>>>>>...>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<..<<<<....<.<<<<..<<<..<<<...>>>.>>>.>>>>.>...>>>>..>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ ...((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((.(.(.((......)).))..)))).)))))......(((.......(((((((..((...(((((((.((((.....((((((....))))))......)))).....((((((((((....)))))))))).....((((((....)))))).)))))))..))))))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....((((((...(.....(.(((((((.....))))))).).....)....))))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))...).)))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((......))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((.....((((....))))....((().))))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..((......)))))...)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((..((((....(.((((..(((..(((...))).))).)))).)...))))..))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... ARE-ABCF VmlR2 bound to a 70S ribosome; 16S rRNA 8c3a 1 3217 3.0 RF02543 URS0000C2FD9C_5476 0003735 0005840 5476 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.......................<<<<<<.....<......>......>>>>>.>...{.....<<....>>..<<<<<......<<.....>>.....>>>>>..[[[...........<<.<<<<<<...>>>>>>.>>.............<<<<<...<<<<<<<<<<<<.<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>....>>>>>>>>....>>>>..>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]....}.............................<<....>>...............<<<<....>>>>..................................<<<<<<<<<<<<.....<<<<..<<<<..>>>>..>>>>..<<<<<<<.<<<<<<<<.<<<<<<<....<<.<<<<<<<......<<<<<<......>>>>>>.......>>>>>>.>.>>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<..<<<<<.....>>>>>..>>>...<<....>>.......<<<<<..<<<<....>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<.......>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<..<<.........>>..>>>>>....>>>>>>..<<<<<<<<.<<......<<<<..<<<....>>>.>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<<<<<....>>>>>>......>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<...............>>>>><<.<<<<<<<<<<<......>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<<...<.<<............................................>>.>...>>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>..............<<<<...>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<.................>>>>>..<<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>....<<<<<<.<<<.<.....<<..........<<<......>>>......>>.......<<<<<<...<<<<<<<..<<<......>>>..>>>>>>>.>>>>>>..............>.>>>.>>>>>>..<<<<<<<.............>>....<<<<<<<<<.<<<....<<<<.<..<<<<<......>>>>>..>>>>>...>>>....>>>>.>>>>>..>>>>>.. .......................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........(((((...((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))).)..))))))))....))))..)))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((((((..(..((((..((((()))))..))))).((((((((((((((((.(((((((........((((((......((((((......)))))).......))))))......))))).))))))))))........(((....)))....))))))))....)))))))))))).<((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..((((....))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((........)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((....((.(((((((.....(((....(((..(.((((...((((.........)))).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((..((.........))..)))))....))))))(.((((((((.((......((((..(((....))).))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........(.((.((......)).))).....))....))...(((((........)))))]]((((..(((((((...((((....)))...(.[[((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((......)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(..(((.....((((....)))).....))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((..(...(..(.............(...(......)...............)...)..)...)..)))))))....((((.....((((..(((((......)))))..........]]..((((...))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))....))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....))))))))....((((((.(((.......((.(........(((......))).....))).......((((((...(((((((..(((......)))..))))))).))))))................))).))))))..(((((((..(.......)..))..(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Crystal structure of ailanthone bound to the Candida albicans 80S ribosome; 25S 8c3a 3 121 3.0 RF00001 URS00001B6144_5476 0003735 0005840 5476 gguugcggccauaucuagcagaaagcaccguuccccguucgaucaaccguaguuaagcugcuaagagcaauaccgaguaguguagugggagaccauacgcgaaacuauugugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<<............>>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of ailanthone bound to the Candida albicans 80S ribosome; 5S 8c3a 4 157 3.0 RF00002 URS0000082EA4_5476 0003735 0005840 5476 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaauaugaauugcagauauucgugaaucaucgaaucuuugaacgcacauugcgcccucugguauuccggagggcaugccuguuugagcgucguu .........................................<<<<<<.((.....>>>.....<.<<<<.....))............>>.>>..>...>>>....<<.....>><<<<<<<<<....>>>>>>>>>.................... .........................................((((((.[[.....))).....(.((((.....]]............)).))..)...)))....((.....))(((((((((....))))))))).................... Crystal structure of ailanthone bound to the Candida albicans 80S ribosome; 5.8S 8c3a B 1761 3.0 RF01960,RF02542,RF01959,RF00177 URS000059AE3B_5476 0003735 0005840 5476 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...<<<<<.{.[[[[>>>>><<<<.<<<<<<...<.<...<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<..<<..<<....<<<...............<<.....<..<<.......>>..>......>>........<<<<<..<<....>>..>>>>><...<<<<<<.......((((((.<<<....>>>..............>>>>>>.....>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>....>.>.....<<<<<<<<.<<<<....>>>>.>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>>.........<<<[[.....<.<<...<<<.<<....<<<<<<<<<<......................>>>>>>>>>>.....<<<<<..................>>>>>....<<<<<.<<.......<<...<.......>..<<<....>>>....>>......>>.>>..>>>.........<<<..<<<<<<<<......))))))...>>>>>>>>>>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<..<<........>>.>>>>>>>>..>>>...<<..]]>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..]]]].}<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<......<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<.....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<.<<<<<<<....>>>>>>>....>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>.....>>.>>>.....>>>>>>>.......>>>>>...>>.>>>>.>>>.....<<<<<<<......<<......<<<.<<<<....>>>>.>>>....>>.......>>>>>>>......<....<<<<<<..........>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<..<...<<<<<<.............>>>>>>...>..>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>....... ....(((..[.[[[..))).((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((...............((.....(..(((.....)))..)......))........(((((..((....))..)))))(.(.(((((........[[.[[..(((....))).....(......)..))))).)...).(..(((..((((..).))).))).)...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(((((((.(.(((....))).).)))).)))......(.(.(...........))..).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....(((((.((((.......(...)..........)))).))))).....(((((..................)))))....(((((.((.(.....((..((.......)).(((....)))....))..)...)).))..))).........(((..(((((.((.......]]..]]..)).)))))))).....))....((..((.((...((((...(..((((((.....((........))........))))))..)........((....))...))))..)).))...))...)))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((..(..........).))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.........(.(((........))).).......)))))...((.(((...(..((((.....(((.(((((....)))..(.((......)))...)).)))....(((((.((...(((..((((.(.(.(((....))).).)....))))..)))..))..(.((((((.....))))))....)..))))).....)).))......).))))).....).)))))...)).)))).))).(...(((((((......((......(((.((((....)))).)))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..((((..(...(((((....(......)...)))))...)..))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>...... Crystal structure of ailanthone bound to the Candida albicans 80S ribosome; 18S 8c3a AS 3229 3.0 RF02543 URS0000C2FD9C_5476 0003735 0005840 5476 ugaccucaaaucagguaggacuacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaacagggauugccucaguagcggcgagugaagcggcaaaagcucaaauuugaaaucuggcgucuuuggcguccgaguuguaauuugaagaagguaucuuugggcccggcucuugucuauguuccuuggaacaggacgucacagagggugagaaucccgugcgaugagaugacccgggucuguguaaaguuccuucgacgagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcuugagaucagacuugguauuuugcaugccgcugcgguuuaccgggccagcaucgguuuggagcggcaggauaauggcggaggaauguggcacggcuucugcuguguguuauagccucugacgauacugccagccuagaccgaggacugcgguuuuuaccuaggauguuggcauaaugaucuuaagucgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccguacgcguaaugaaagugaacgaaggugggggcccauuagggugcaccaucgaccgauccugauguguucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagaagucuugggguugaaaugaccuuaacuuauucucaaacuuuaaauauguaagaaguccuuguugcuuaauugaacguggacaauugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacgugaaguuaaagugccggaaugcacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcgugcuacuuauacuucaccgugauugcuguuuugacgcuuucacgaguaggcaggcguggaggucagugacgaagccuuugcuguaaagcugggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccaugucaacagcaguuggacauggguuagucgauccuaagagauggggaagcuccguuucaacgugcuugauuuuucaggccaaccaucgaaagggaauccgguuaaaauuccggaacuuggauauggauucuucacggcaacguaacugaauguggagacgucggcgugagcccugggaggaguuaucuuuucuucuuaacagcuuaucacccuggaauugguuuauccggagauggggucuuauggcuggaagagcgcgguaauuuugccgcguccggugcgcuuacgacgguccuugaaaauccacaggaaggaauaguuuucaugccaagucguacucauaaccgcagcaggucuccaagguuaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaaggaucgggcacguuuaacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugugauggucagaaagugauguugacacaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaaaagacauggaggguguagaauaagugggagcuucggcgccggugaaauaccacuaccucuauaguuuuuuuacuuauucaaugaagcggagcuggaggucaaacuccacguucuagcauuaagcccucugggcgauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagguguccuaagggggacucauggagaacagaaaucuccaguagaacaaaaggguaaaaguccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaucgcaauaguaauugaacuuaguacgagaggaaccguucauucagauaauugguuuuugcggcugucugaucaggcaacgccgcgaagcuaccaucugcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcgaugauuuuugcccugcacauuuuagauggauacgaauaagacuuuuuagucgcuggaccauagcaggcuggcaacggugcgcuuagcggaaaggcuuugugcgcuugccggcggauagcaaugucaacaugcgcggggauaaauccuuugcauacgacuuagauguacaacggaguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagcucuuguugucugauuugu .......................<<<<<<.....<......>......>>>>>.>...<.....<<....>>..<<<<<......<<.....>>.....>>>>>..<<<...........<<.<<<<<<...>>>>>>.>>.............<<<<<...<<<<<<<<<<<<.<<<<<<<.....<<<<......>>>>.(.......<<<......)>>>....>>>>>>>....>>>>>>>>....>>>>..>>>>>........<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>....>.............................<<....>>...............<<<<....>>>>..................................<<<<<<<<<<<<.....<<<<...<<<<......>>>>...>>>>..<<<<<<<.<<<<<<<<.<<<<<<<....<<.<<<<<<<......<<<<<<......>>>>>>.......>>>>>>.>.>>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<..<<<<<.....>>>>>..>>>...<<....>>.......<<<<<..<<<<....>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<.......>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<..<<.........>>..>>>>>....>>>>>>..<<<<<<<<.<<......<<<<..<<<....>>>.>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<<<<<....>>>>>>......>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.....{{<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..[[[..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<...............>>>>><<.<<<<<<<<<<<...........>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<..<<<<<<<<<<<<...<<.................<......>...................>>..>>.>>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>..........}}..<<<<...>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))......<<<<<<<..<<<<.))))))>>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>....<<<<<<<<..<<<<...<<<<<.................>>>>>..<<<<<...<<<<....<<<<<<<<<<]]].>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.....<<<<<<.<<<.......<<..........<<<<....>>>>......>>.......<<<<<<...<<<<<<<..<<<......>>>..>>>>>>>.>>>>>>................>>>.>>>>>>..<<<<<<<.............>>....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. .......................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........(((((...((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))).)..))))))))....))))..)))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((((((..(..((((...((((.()...))))...))))).((((((((((((((((.(((((((........((((((......((((.(......).)))).......))))))......))))).))))))))))........(((....)))....))))))))....)))))))))))).<((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..((((....))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((....((.(((((((.....(((....(((..(.((((....((((.......))))..)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{..((((.(((...((.........))...))).....(...((......)).).))))....)))))))))))))..........]]].)....))))))))))...)))))))(((((..((.........))..)))))....))))))(.((((((((.((......((((..(((....))).))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........(.((.((......)).))).....))....))...(((((........)))))]]((((..(((.(((...((((....)))...(.[[((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....)))...))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((...........)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(..(((.....((((....)))).....))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.((((((((..((((((((((((....(.................(......)...................)...)).))))))))))....((((.....((((..(((((......)))))..........]]..((((...))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).....((((((.(((.......((.(........((((....)))).....))).......((((((...(((((((..(((......)))..))))))).))))))................))).))))))..(((((((..(.......)..))..(.(((((((((.(((....((((.(..(((.((..)..).)))..)))))...)))....)))).)))))).))))).. Crystal structure of ailanthone bound to the Candida albicans 80S ribosome; 25S 8c3a AT 121 3.0 RF00001 URS00001B6144_5476 0003735 0005840 5476 gguugcggccauaucuagcagaaagcaccguuccccguucgaucaaccguaguuaagcugcuaagagcaauaccgaguaguguagugggagaccauacgcgaaacuauugugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<<............>>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of ailanthone bound to the Candida albicans 80S ribosome; 5S 8c3a AU 158 3.0 RF00002 URS0000082EA4_5476 0003735 0005840 5476 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaauaugaauugcagauauucgugaaucaucgaaucuuugaacgcacauugcgcccucugguauuccggagggcaugccuguuugagcgucguuu .........................................<<<<<<.((.....>>>.....<.<<<<.....))............>>.>>..>...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............)).))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of ailanthone bound to the Candida albicans 80S ribosome; 5.8S 8c3a CM 1765 3.0 RF01960,RF02542,RF01959,RF00177 URS000059AE3B_5476 0003735 0005840 5476 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguaccuuacuacuuggauaaccgugguaauucuagagcuaauacaugcuuaaaaucccgacuguuuggaagggauguauuuauuagauaaaaaaucaaugccuucgggcucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaaucccgacacggggagguagugacaauaaauaacgauacagggcccuuuugggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaaaagcguauauuaaaguuguugcaguuaaaaagcucguaguugaaccuugggcuuggcuggccgguccauaugcguacuggacccagccgagccuuuccuucuggguagccauuuauggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggccuuugcucgaauauauuagcauggaauaauagaauaggacguuaugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucggggguaucaguauucaguugucagaggugaaauucuuggauuuacugaagacuaacuacugcgaaagcauuuaccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgguuguuguucuuuuauugacgcaaucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauagugcugcuagcauuugcugguauagucacuucuuagagggacuaucgauuucaagucgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgaguauaagccuuggccgagaggucugggaaaucuugugaaacuccgucgugcuggggauagagcauuguaauuguugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuacuaccgauugaauggcuuagugaggccuccggauugguuuaggaaauucuggaaccgagaagcuggucaaacuuggucauuuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucau ...<<<<<.{.((((>>>>><<<<.<<<<<<...<.<...<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<..<<..<<....<<<...............<<.....<..<<.......>>..>......>>........<<<<<..<<....>>..>>>>><...<<<<<<.......{.((((.<<<....>>>..............>>>>>>.....>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>....>.>.....<<<<<<<<<<<<.....>>.>>>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>>.........<<<[[.....<.<<...<<<.<<....<<<<<<<<<<.........<..>.............>>>>>>>>>>.....<<<<....................>>>>....<<<<<.<<.......<<...<.......>..<<<....>>>....>>......>>.>>..>>>.........<<<..<<<<<<<<<.....)))).}..>>>>>>>>>>>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<..<<........>>.>>>>>>>>..>>>...<<..]]>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..)))).}<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<.....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<.<<<<<<<....>>>>>>>....>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>.....>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<......<<<.<<<<....>>>>.>>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<..<...<<<<<<<.<.<...>.>.>>>>>>>...>..>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>....... ....(((..[.[[[..))).((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((...............((.....(..(((.....)))..)......)).........((((..((....))..)))).(.(.(((((.........[.[[[.(((....))).....(......)..))))).)...).(..(((...(((..).))..))).)...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(((((((.(.(.......)..).)))).)))....(.(.(.(...........))..)......)..((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((((((....(..(..().)....).......))))))))))......((((..................)))).....(((((.((.(.....((..((.......)).(((....)))....))..)...)).))..))).........(((..(((((.((......]]]...]..)).)))))))).....))....((..((..(...((((...(..((((((.....((........))........))))))..)........((....))...))))..)..))...))...)))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((..(..........).))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.........(.(((........))).).......)))))...((.(((...(..((((.....(((.(((((....)))..(.((......)))...)).)))....(((((.((...(((..((((.(.(((((....))))).)....))))..)))..))..(.((((((.....))))))....)..))))).....)).))......).))))).....).)))))...)).)))).))).(...(((((((......((......(((.((((....)))).)))....)).......)))))))......(....((((((..........))))))....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..((((..(...((((((.............))))))...)..))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>...... Crystal structure of ailanthone bound to the Candida albicans 80S ribosome; 18S 8c4u H 20 3.36 URS000268141C_11602 37221161 11602 uaggaguauccaccgcaaga ..<<.....>>......... ..((.....))......... Hantaan virus polymerase in replication pre-initiation state; RNA (5'-R(P*UP*AP*GP*GP*AP*GP*UP*AP*UP*CP*CP*AP*CP*CP*GP*CP*AP*AP*GP*A)-3') 8c4u T 18 3.36 URS0002681417_11602 37221161 11602 uuuugcggaguacuacua .................. .................. Hantaan virus polymerase in replication pre-initiation state; RNA (5'-R(P*UP*UP*UP*UP*GP*CP*GP*GP*AP*GP*UP*AP*CP*UP*AP*CP*UP*A)-3') 8c4v H 19 3.14 URS000268141C_11602 37221161 11602 aggaguauccaccgcaaga .<<.....>>......... .((.....))......... Hantaan virus polymerase in replication elongation state; RNA (5'-R(P*AP*GP*GP*AP*GP*UP*AP*UP*CP*CP*AP*CP*CP*GP*CP*AP*AP*GP*A)-3') 8c4v T 12 3.14 URS0002681417_11602 37221161 11602 agucuacuacua ............ ............ Hantaan virus polymerase in replication elongation state; RNA (5'-R(P*AP*CP*UP*AP*CP*UP*A)-3') 8c6j 2 142 2.8 RF00004 URS00003EE995_9606 36867703 0045131 0000348 0005686 9606 aucgcuucucggccuuuuggcuaagaucaaguguaguaucuguucuuaucaguuuaauauauauuaaauggauuuuuggagcagggagauggaguccacuccacgcaucgaccugguauugcaguaccuccaggaacggugc .....................................................<<<<<<..>>>>>>.................<<<<.<<<<.>>>>>>>>..<<<<<<.<<<<<.............>>>>>..>>>>>> .....................................................((((((())))))).................((((.((((.))))))))..(((.((.(((((.............)))))..)).))) Human spliceosomal PM5 C* complex; U2 snRNA 8c6j 5 113 2.8 RF00020 URS0000118C49_9606 36867703 0000244,0000353 0005682,0046540 9606 acucugguuucucuucagaucgcauaaaucuuucgccuuuuacuaaagauuuccguggagaggaacaacucugagucuuaacccaauuuuuugagccuugccuuggcaaggcu <<<<.<<<<<<<<<<<<........<<<<<<<<...........>>>>>>>>...>>>>>>>>>>>....>.>>>>.................<<<<<<<<....>>>>>>>> ((((.((((((((((((...((...((((((((.(.......).)))))))).)))))))))))))....).)))).................((((((((....)))))))) Human spliceosomal PM5 C* complex; U5 snRNA 8c6j 6 97 2.8 RF00026 URS000035C796_9606 36867703 0030621 0000244,0000353 0005688,0046540 9606 gugcucgcuucggcagcacauauacuaaaauuggaacgauacagagaagauuagcauggccccugcgcaaggaugacacgcaaauucgugaagcguu <<<<<.<<....>>>>>>>.....................................<<...<<<.....>>>....>>................... ((((..((....)).)))).....................................((..((((.....)))..).))................... Human spliceosomal PM5 C* complex; U6 snRNA 8c6j E 24 2.8 URS0002681447_9606 36867703 9606 gcugccgacgagaccgccgccaag ........................ ........................ Human spliceosomal PM5 C* complex; PM5 5' Exon 8c6j I 84 2.8 URS0002681437_9606 36867703 9606 guauguaucaagcuuacaagacugauucuuauguauuuacugaccuguguuuuuuugcuacuuuuuuucuuuucuccccuuccc .................................................................................... (...........................................................)....................... Human spliceosomal PM5 C* complex; PM5 Intron 8c8x A 2705 3.93 RF02541 URS00004B0F34_562 36797249 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccgucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggaggcugauaccgcccaagaguucauaucgacggcgguguuuggcacgucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<......<<..<<<<<<<<<<<<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>>.>>...............<<....>>....>>.........<<<<.....>>>>...................>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<.......>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<..<<<<<........>>>>>.>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<......<<...<<<.<<<<...<<<<<<.......>>>>.>>...>>>>.>>>..>>.......>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><<<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>.>>.....>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<.<..<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....[[[...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<..<<....>>...>>>>>........>>>>>>>>..>>>>>.<<<<.........>>>>.........<...............>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.<<<.<<<....<<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<<<<<...<<......<<<<..<<....>>..>>>>...>>.............>>>>>...>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>>..<<.......<<<.................>>>........>>...>>>...>>>>>>>>>>>....<<<<<<<...<<<<...<<<<<<.....<....>....>>>>>>..<<<<....<<<<...<<<<.<<<<<<]]].>>>>>>...>>>>...>>>>..>>>>...<<<.<...<<<<...........>>>>....>>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((......((..((((((((.((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))((((.((....)).))))..((((((((.........))))))))..))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......((((((((((.((.(((...(((((......)))))[[(...).(((.....]])))...)))...)).))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......))..)))))).))...............((....))....))......(..((((.....))))............)......)))))))))).....(.((((..((((........))))..))))...(.(........).).((((((....(((((((((.(((..((....((.....))....))...((....))..(((.......))).....))).)))))))))..((.(...((((((.....((((((((((.(..(...((((.(......).))))...)[..)...((..(((((........))))).))..).))))))))).(.((.......))...)..))))))......).))..((((((....((((......))))..(((((((..((.((((((.(....(((...(((.((((...((((((.......)))).))...)))).)))..)).).....)))))).).)..)))))))).....((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..((....))..))))).))...........]]].)...))))))))))...)))))))((((.(..(....)..).))))....))))))(.(((((...(((......((.(((((....))))).))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(.(.(.(((...(((....)))...)))..).))..(((((........)))))]]((((((((((.((...((((....((((..(((..(((((.((((((...{{{.).))))).((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...)).....)))))))))).))).))).....((......)).)))).(((.......)))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((....(((....])))....)))...))))))(...).......(((((.(((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..((((((...(((.........((((..((....))...)))).........))).))))..)))))(((.............)))........((...........)..)....))))...)).).))))).)..))).)))))))).)))))).....)).[..(((((......].)))))..((((((((.(((.(((.....((((.((((((..(((((.(((.(((((.(((((((((((..(...(.........(.(((..(.(......(((.(.((....)))..)))...)).............))).))...)..)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........])))))).[((....((((((...(((((.........))))).....((][.[[[))....))))))....((((..((((..{.))))..)))).(((....))).))]]].].....(((((.(.((..]]]]..))).)))))......}......))))..))))))..((((.....(.((.................)).)......))).).)))...)))))))))))[...(((((((...((((.....((.(.....(....).....)))....(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Cryo-EM captures early ribosome assembly in action; 23S rRNA 8c8x B 119 3.93 RF00001 URS000080E133_562 36797249 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<...<...<<<<<<<<...>>>>>>>>.....>.>>...>>>>>>>>>> ((((((((((.....((((((((....(.(.(((...(.....)...)))...).)...)))))).)).((.......((((((((...)))))))).......))...)))))))))) Cryo-EM captures early ribosome assembly in action; 5S rRNA 8c8y A 2548 3.03 RF02541 URS00004B0F34_562 36797249 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcgucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccgguguaaacggcggccgacgguccuaagguagcgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<..>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<..>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<..>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<..<<....>>..>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<....<<..>>.....>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<....>>>>>.<<<<.>>>>...............>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<...<<<<.<<<.<<<<<.<<<<<<<<.<..<<<............<<<<<...<<.......<<<..<......>..>>>....>>.............>>>>>...>>>..>>.>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>...<<<.......>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<....(((.>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>...]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))((((((......)))))).(((((((((.........))))))))).))...((((((.....(..)......))))).).........((....))...(((((.....((.....))....)))))...((((.((((......(((.(((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))))))).)))...))))...)....(((((((...[.......)))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..(((.......))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((.(....).))).((((((((..((((((((((.....(((...(((.(((()))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(.(((..(.().)..))).).))...........]]].)...))))))))))...)))))))((((((.((....)).))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..(((((.((((((...{{{.).))))).((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((..((..((....))))..((((.)))).........()....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((...((((..((.(((((.(((((((.(...((..............((((...((.......((...((....))...))....)).............)))).....))..)..)))))))...(((.((((((.....)))))))))....))))).))...))))...(((.......)))(((.((...........)).)))([((...((.((((...((((((.......)))))).......][.[[[......)))).))...((((..((((..{.))))..)))).(((....))).))]]].].....((.((((.((..]]]]..)))))).)).....)}......))))..))))))...))..)))))))))))[...(((((((...((((..(.(((((.....(....)....))))).).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Cryo-EM captures early ribosome assembly in action; 23S rRNA 8c8y B 119 3.03 RF00001 URS000080E133_562 36797249 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>> ((((((((((.....((((((((....((((.((...(.....)...)).)..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))) Cryo-EM captures early ribosome assembly in action; 5S rRNA 8c8z A 2205 3.12 RF02541 URS00004B0F34_562 36797249 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagcaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcgucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauuguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<....>>>>>>...>..>.>>..<<<<<<....<<<........>>>.<<<<<<<<...<<<<<<<.<<....<<<...<<<.<<<<........>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<..>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<..<<<<....>>>.>.>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<.....<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>.........>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<.............................<<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<...<<<<.<<<.<<<<<.<<<<<<<....>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>...<...........><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>...]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<.............>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))((((((......)))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.(((.(.....(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((....[........))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..))))...(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((....))))))......).))..((((((....(((........))).((((((((..((((((((.((....(((...(((.((((...()...)))).)))..)).).....)))))).)))..)))))))).)...((((((((.(......).))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(..((..((()))..))..).))...........]]].)...))))))))))...)))))))((((...((....))...))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((.(...((((....((((..(((..((((((((((((...{{{.).))))))(...(((....(((.((((.(((.(.......)))).))))...)))..[.)))....)(..(((((....)))))...))))))...)))...))))(..).....))))...).....))))))))))).))).)))......(......)..)))).((((.....))))..))))..((((....((.............................((((((.....(((...(((((..)]))))...)))...))))))(...).......)).)))))).....)).[..(((((......].)))))..((((((((.((..((......((((.((((((....((..(((.(((((.((((((.(..).))))))...(((.((((((.....)))))))))....))))).)))...))....(...........)((((((...........))))))([.(...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).).]]].].....((((.((.((..]]]]..))).))))).....)}......))))..))))))...))...))))))))))[...(((((((...((((..(.(((((.....(....)....))))).).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((.(.............).))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Cryo-EM captures early ribosome assembly in action; 23S rRNA 8c8z B 119 3.12 RF00001 URS000080E133_562 36797249 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<<.....<<<<<<<<....<<<.<<<.............>>>...>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>> .(((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))). Cryo-EM captures early ribosome assembly in action; 5S rRNA 8c90 A 2100 3.15 RF02541 URS00004B0F34_562 36797249 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcgucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcgccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaaguccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacgucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<....<<<..<<<<<<<<<<<<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>...<<..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>..........<<<<<<.........>>>>>>........<<<<<..((((>>>>>..>>.......>>.>>>>>>>.>>...............<<....>>....>>.........<<<<.....>>>>.............>....>>>>>>>>>>>.......<<<<..<<<<........>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<....>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<.<....<<<...<<<.<<<<....>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<........>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<..>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<.<<....>>.>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<....<<<....>>>....>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<.<...<<<<....<<<<..<<<..<<<<<<<<<<<....[[[...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<<..>>>>>>...>>>>>>...>>>...>>>.>........>>>>...>.....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<..>>>><<<<<<.....<<<...<<.<<....>>>>...>>>...>>>>>>............<<<<..>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.<<....<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<.........>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.........>>..>>>>>>>>>>>....<<<<<<<...<<<<....<<<<<.....<....>....>>>>>...<<<<<...<<<<...<<<<<<<<<<<]]].>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))....(((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)......((.((...........)).).).......(((((..[[[[)))))..)).......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((........))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..(((.......))).....)))))))))))))..((.(...((((((....))))))......).))..((((((....((((......)))).((((((((..((.(((((.((....(((...(((..((......))..)))..)).).....)))))).).)..)))))))).)...((((((((..........))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(..((..((()))..))..).))...........]]].)...))))))))))...)))))))((((.(.((....)).).))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((...(((...(((....)))...)))...)))..(((((........)))))]](((.((((((.((...((.((...(.((..(((..((((((((((((...{{{.).))))))(....(((...(((((.((((((.((.....)))))))).)..))))..[))).....)(..(((((....)))))...))))))...)))...))).(..).....))))...)).....)))))).))).))).)))......(......)..)))).(((.......)))..))))..((((....(((((((..((..(....(.......((((()))))((((((.....(((....(.((...])))....)))...))))))(...).......((((())))).)..)))..))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.((..(.....((((((...........)))))).[((...(((((((...((((.(........))))).....((][.[[[))....)))))))...((((..((((....))))..)))).(((....))).))]]].].....(((((((.((..]]]]..)))))))))..........)...))))))))))[...(((((((...((((..(..((((.....(....)....))))..).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((.(.............).))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Cryo-EM captures early ribosome assembly in action; 23S rRNA 8c90 B 119 3.15 RF00001 URS000080E133_562 36797249 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.....<.<<<<<<<<...>>>>>>>>...>...>>...>>>>>>>>>> ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))) Cryo-EM captures early ribosome assembly in action; 5S rRNA 8c94 A 1668 3.8 RF02541 URS00004B0F34_562 36797249 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggagccugcgcggauaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacaaagcgggugaaaagcccgcucgccggaagaccaaguggucagguagagaauaccaaggcgcugagagaacucgggugaaggaacagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaaguccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<....<<<..<<<<<<<<<<<<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<..<<<<.........>>>>..>>......<<<<<..{.[[>>>>>..>>>......>>.>>>>>>>.>>...............<<....>>....>>.........<<<<.....>>>>.............>....>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<....>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>..<<<<<<<...<<<<<<<.<<....<<<...<<<.<<<<.>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.....<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..>>>>>.>>......))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><<<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>.>>.....>>>>>><......<<..<<<<<<.......>>>>>><<<<....<<<<<..>>>>>...<<.....>>....>>>>.<<<<....<<.............>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.<<....<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..]]}...>>>>>>>>>..........>>..>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<....>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. .(((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....(((((((..(((]]]..].)))......)))))))...)))....(((....)))((((((......))))))..((((((((.........))))))))..))...((((((.....(...[..)......)))))..)........((....))...(((((.....((.]...))....)))))...((((.(((.(.....(((.(((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))))))).)))...))))...)....((.(.(((.........))).).))......(((((..[...)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..))))...(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((....))))))......).))..((((((....(((((....))))).((((((((..((((((((.((....(((...(((.(((...))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(.(((..))).).))......]]].)...))))))))))...)))))))((((...((....))...))))....))))))(.(((((...(((.......(((((((....)))))))....)))..)))))..).....))))))(......((..((((((.......))))))((((....((((....))))...((.....))....)))).((((....((.............)).)))))).....)).[..(((((......].)))))..((((((((.((...(....((((((...........))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((....]...))))))))).....)}...)....))))))))))[...(((((((...((((..(.(((((.....(....)....))))).).(((((...((((...(((((((((((....))))))..)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))).). Cryo-EM captures early ribosome assembly in action; 23S rRNA 8c94 B 119 3.8 RF00001 URS000080E133_562 36797249 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>> ((((((((((.....((((((.(....(((((((...(.....)...))))..)))...).)))).)).((.......((((((((...)))))))).......))...)))))))))) Cryo-EM captures early ribosome assembly in action; 5S rRNA 8c95 A 1220 4.92 RF02541 URS00004B0F34_562 36797249 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcagcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagucggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacagacucagugaaauugaacucgcugugugcaguguccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcuaggcuuaaccu <<<<<<<<......<<<<<<<<<<<....<<<..<<<<<<<<<<<<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>....<<<<<.....<<....>>......>>>>>...........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<......<<<<<<<<<<<<..<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>....>>>>>>>>>>>>...>>>>........<<<.<<<...........>>>.>>>......<<<<...((((.>>>>..>>>......>>.>>>>>>>.>>.............<.<<....>>...>>>.........<<<<.....>>>>.............>....>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>..<<<<<<<...<<<<<<<<<.....<<<.......>>.>.....>>>>>>>.>>...>>>>>>>.....<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<......))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><<<<<<<....<<......<<<<<<<<....>>>>>>>>...>>...>>>>>.>>.....>>>>>>.......<<.......>>............<<<<....>>>>.<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....)))))))..((((((((.........))))))))..))...((((((.....(...[..)......)))))..)........((....))...(((((.....((.]...))....)))))...(((..((((......(((.((((((..(.(((...(((.(......).)))[[(...).(((.....]])))...)))....).)))))).)))...))))........((...((...........))...))......((.((..[[[[)).))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((.(..(((((......)))))..).))...(.(........).).((((((....(((((((((((.(..((....((.....))....))...((....))..((((.....)))).....).)))))))))))..((.(...((((((.))))))......).))..((((((....(((((....))))).((((((((..((((((((.((....(((.......)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(]]])....))))))))))...)))))))((((.(.((....)).).))))....))))))(.(((((....((......((.(((((....))))).))...))...)))))..).....)))))).......((.......))......).[..(((((..].)))))((((((...........)))))).[.(...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((....))))..)))).(((....))).).]]].].....(((((((.((..]]]]..)))))))))....)))))))). Cryo-EM captures early ribosome assembly in action; 23S rRNA 8c95 B 119 4.92 RF00001 URS000080E133_562 36797249 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>> ((((((((((.....((((((.(....(((((((...(.....)...))))..)))...).)))).)).((.......((((((((...)))))))).......))...)))))))))) Cryo-EM captures early ribosome assembly in action; 5S rRNA 8cam a 2690 1.86 RF02541 URS00004B0F34_679895 37550453 0003735 0005840 679895 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagcgucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcguaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaaucagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaacc <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<.<....<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>..>>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<...<<<<<<.....>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<....>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<..>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<..>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<..<<....>>...>>>>>..>....>>>>>>>>>..>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<..>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>.(<<...<<<<<<<...........<<)..(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>> ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((.(((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))))))).)))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((.....))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((....)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(..)...)))..))))).))...........]]].)...))))))))))...)))))))(((((((..)))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((..))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.......).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))) Evernimicin bound to the 50S subunit; 23S rRNA 8cam b 34 1.86 RF00001 URS0000049E57_679895 37550453 0003735 0005840 679895 gaugguaguguggggucuccccaugcgagaguag .......<<<<<<<<...>>>>>>>>........ .......((((((((...))))))))........ Evernimicin bound to the 50S subunit; 5S rRNA 8cas 1 75 3.3 RF00005 URS00002CB170_580240 37169754 0030533 0006412 580240 agcgccgunncgcagnggaagcgcncagggcucaunacccugaunnnnucggaucgnaaccgngcggcgcuacca <<<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((....[..)))).(((((.......))))).....(((((..]....)))))))))))).... Cryo-EM structure of native Otu2-bound ubiquitinated 48S initiation complex (partial); tRNA 8cas 2 1763 3.3 RF01960,RF02542,RF01959,RF00177 URS00005F2C2D_580240 37169754 0003735 0005840 580240 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugagcuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauu ...<<<<<.{.[[[[>>>>><<<<.<<<<<<...<.<...<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<..<<..<<....<<<..........<.....<<.<<<.....>>>.>>......>.........<<<<<..<<....>>..>>>>><.<.<<<<<<......(((((((.<<<....>>>..............>>>>>>.>...>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<<..>>>.>...>>>>>>.........<<<....<<<.....>>>..>>>..>....>.>.....<<<<<<<.<.<<<....>>>.>.>>>>.>>>......<<..<...........>..>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>>>>>.........<<<[[.....<.<<...<<<.<<....<<<<<<.<<<<..............>>>>.>>>>>>....<<<<<<....................>>>>>>...<<<<<.<<.......<<...<.......>..<<<<...>>>>....>>......>>.>>..>>>.........<<<..<<<<<<<<.....))))))).>>>>>>>>.>>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..]]>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..]]]].}<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>......<....<<<<<<..........>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<.<<<<.<<<<....>>>>.>>>>.>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>........ ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..........((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[[.[[[.(((....))).....(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(((((((.(.(((....))).).)))).)))....(.(((.(...........)).))......)..((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((................))).))))))....(.((((....................)))).)...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(....(.((.(((.....]]].]]].))).)).)...).....))...(((..((.((...((((..((..((((((.(...((........))......).))))))..)).......((....))...))))..)).))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].].((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).)...(.(..((.(..((((.((..(..((((.((.(((..(.((..(...((((((..((((.((((....)))).))))..))))))...)..)).)..))).)).)))).)..)).))))...).))...)..)..(((((((((....)))))))))>....... Cryo-EM structure of native Otu2-bound ubiquitinated 48S initiation complex (partial); 18S ribosomal RNA 8ccs AA 3190 1.97 RF02543 URS000061F377_4932 38030725 0003735 0005840 4932 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugnaacnnggaccaaggagunuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccnanagauggugancuaugccugaauagggugaagccagaggaaacucugguggaggcucguancgguucugncgugcaaaucgaucgucgaaunuggguauagnggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcngaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaunuuggugguagunncaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaanguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucgcgaucaacuuagaacugguacggacaaggggaaucugacugucuaauunaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugccnagugcucugaaugucaaagugangaaauucaaccaagcgcggguaaacggcgggaguancuaugacucucuuaagguagcnannugccucnucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugunccuaucuacnaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcungacncuaguuugacauugugaagagacauagaggguguagaauaagugggagcuucggcgccagugaaauaccacuaccuuuauaguuucuuuacuuauucaaugaagcggagcuggaauuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcugnggcggcacaucugunaaacgnuaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauunucagngugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuanangugccagaaaaguuaccacagngauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuungaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggaunnuucacccacuaauagggaacgugngnuggguuuagancgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuugguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[...<.......<<.<<<<<<...>>>>>>.>>.......>.....<<<<<<.<<<<<<.<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>.>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<....<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<<..>>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<...<<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>>.<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<..<.<<<<....<<<<<<...>>>>>>..>>>>.>..>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<......<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>....>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>>..<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<.<............>.>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>...<...<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<<....>>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>...>......>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<...............>>>>><<.<<<<<<<<<<<>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<<.<...<<<..........................................>>>..>..>>>>>>>>>>...<<<<<.....<<<<..<<<<..>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<....>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((.(((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))).))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((...(((((((((((((((((((((((.......(((((((......((((.(....).)))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).<((((........))))((((((....((((((.((((((..(((..((((.......))))..)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((....((.(((((((.....(((....(((..(.((((....(((.........)).).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....))).........(.................)....))....))...(((((........)))))]]((((..(((((((...((((....)))...(.[[((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.((((((((((()))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.....((.....((((....)))).....))..))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.(((..(.(((................(......)..................))).).).)).)))))))....((((.....((((..((((()))))..........]]...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(((.((..)).)))..)))))...)))....)))).)))))).))))).. 80S S. cerevisiae ribosome with ligands in hybrid-1 pre-translocation (PRE-H1) complex; 25S ribosomal RNA 8ccs BB 121 1.97 RF00001 URS000055688D_4932 38030725 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). 80S S. cerevisiae ribosome with ligands in hybrid-1 pre-translocation (PRE-H1) complex; 5S ribosomal RNA 8ccs Bb 76 1.97 RF00005 URS000011107D_4932 38030725 0030533 0006412 4932 gcggauuuagcucaguugggagagcgccagacugaanaucuggagguccuguguucgauccacagaauucgcacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<.........>>>>>>>>>>>.... (((((((..((((........)))).(((((.......))))).....(((...........)))))))))).... 80S S. cerevisiae ribosome with ligands in hybrid-1 pre-translocation (PRE-H1) complex; Transfer RNA Phe 8ccs CC 158 1.97 RF00002 URS00001BF64E_4932 38030725 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... 80S S. cerevisiae ribosome with ligands in hybrid-1 pre-translocation (PRE-H1) complex; 5.8S ribosomal RNA 8ccs Cc 77 1.97 RF00005 URS000057545F_562 38030725 0030533 0006412 562 cgcgggguggagcagcccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... 80S S. cerevisiae ribosome with ligands in hybrid-1 pre-translocation (PRE-H1) complex; Transfer RNA fMet 8ccs Dd 13 1.97 38030725 4932 aagaaaauguuuu ............. ............. 80S S. cerevisiae ribosome with ligands in hybrid-1 pre-translocation (PRE-H1) complex; Messenger RNA 8ccs c 1604 1.97 RF01960,RF02542,RF01959,RF00177 URS000268149C_4932 38030725 0003735 0005840 4932 uaucugguugauccugccaguagucaunugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauacagugaaacugcgaauggcucnuuaaaucaguuaucguuuauuugauaguucccuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucagauguauuuauuagauugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauncaaggnaggcagcaggcgcgcnaauuacccaauccuaauucagggagguagugacaauaaauaacgauacauguaauuggaaugaguacaauguaaauaccuuaacgaggnacaauuggagggcaagucugnugccagcagccgcggnaauuccagcuccaauagcguauauuaaaguuguugcaguunaaaagcucguaguugaacuuugggcccgguugcaacggggccuuuccuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauungcauggaauaauagaauaggacguuuaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagancgaaaguuaggggaucgaagaugaucagauacngucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaangcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacncaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuuguggguggngnugcauggcnguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacangucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacnagnaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgnccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuucnguaggugnnccugcggaaggaucauu ...<<<<<.[.((((>>>>><<<<.<<<<<<...<.<...<......<<<.<<<..<<....<<....<<......>>...>>.>>......<<........<<<..<<..<<....<<<............<<......<<.<<.......>>.>>......>>........<<<<.>>>><...<<<<<<.............>>>>>>.....>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>..>>>..>....>.>.....<<<<<<..>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>>.........<<<((.....<.<<...<<<.<<....<<<<<<.<<<..>>>.>>>>>>.....<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........<<<.....>>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<<.....>.>>>>>>>>>>>..>>>...<<..))>>...>>.....>>>.>>>.<<<......<<<......>>>....>>>..)))).]<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<..<........<<.<<<........>>>.>>......>..>>...<<.<<<..<<<<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<.<<<<....>>>>.>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>...>.>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>......<....<<<<<<..........>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<..>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>........ ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((......))...))[))......(((.......(((..((..((....(((........(...((......((.(((.....))).))......)).........(((.))).(.(.((((((....(......).)))))).)...)..)((((..(((.....))).))))....)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)....).).....((((((()))).)))....(.(((.(...........)).))......)..((((([[....(.((((.....((..]])).......))))))))))..))))))))))..[......((([[...(.(.((...(((.((....(.((((.(((()))).)))).).....(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........((...()..)).....))...(((..((.((...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)).))...))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..((((((((.(((........)))))))))))..)))...((..]]))...))...].))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(...(........((.(((........))).)).......)..)...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..((((......((....))........))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...(((())))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}....... 80S S. cerevisiae ribosome with ligands in hybrid-1 pre-translocation (PRE-H1) complex; 18S ribosomal RNA 8cd1 A 2883 3.0 RF02541 URS000197CF82_208964 38443577 0003735 0005840 208964 gucaagugaagaagcgcauacgguggaugccuuggcagucagaggcgaugaaagacgugguagccugcgaaaagcuucggggagucggcaaacagacuuugauccggagaucucugaaugggggaacccaccuaggauaaccuagguaucuuguacugaauccauaggugcaagaggcgaaccaggggaacugaaacaucuaaguacccugaggaaaagaaaucaaccgagauucccuuaguaguggcgagcgaacggggauuagcccuuaagcuucauugauuuuagcggaacgcucuggaaagugcggccauagugggugauagccccguacgcgaaaggaucuuugaagugaaaucaaguaggacggagcacgagaaacuuugucugaacauggggggaccauccuccaaggcuaaauacuacugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggagaggggagugaaauagaaccugaaaccguaugcguacaagcagugggagccuacuuguuaggugacugcguaccuuuuguauaaugggucagcgacuuauauucaguggcaagcuuaaccguauaggguaggcguagcgaaagcgagucuuaauagggcguagucgcuggguauagacccgaaaccgggcgaucuauccaugagcagguugaagguuagguaacacugacuggaggaccgaacccacucccguugaaaagguaggggaugacuuguggaucggagugaaaggcuaaucaagcucggagauagcugguucuccucgaaagcuauuuagguagcgccucauguaucacucugggggguagagcacuguuucggcuagggggucaucccgacuuaccaaaccgaugcaaacuccgaauacccagaagugccgagcaugggagacacacggcgggugcuaacguccgucgugaaaagggaaacaacccagaccgccagcuaaggucccaaaguugugguuaagugguaaacgaugugggaaggcuuagacagcuaggagguuggcuuagaagcagccacccuuuaaagaaagcguaauagcucacuagucgagucggccugcgcggaagauguaacggggcucaaaccacacaccgaagcugcgggugucacguaagugacgcgguagaggagcguucuguaagccugugaaggugaguugagaagcuugcuggagguaucagaagugcgaaugcugacaugaguaacgacaaugggugugaaaaacacccacgccgaaagaccaaggguuccugcgcaacguuaaucgacgcaggguuagucgguuccuaaggcgaggcugaaaagcguagucgaugggaaacagguuaauauuccuguacuucugguuacugcgauggagggacggagaaggcuaggccagcuuggcguugguuguccaaguuuaaggugguaggcugaaaucuuagguaaauccgggguuucaaggccgagagcugaugacgagucgucuagaugacgaagugguugaugccaugcuuccaagaaaagcuucuaagcuucagguaaccaggaaccguaccccaaaccgacacagguggucggguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggcaccguaacuucgggagaaggugcgccggcuagggugaaggauuuacuccguaagcucuggcuggucgaagauaccaggccgcugcgacuguuuauuaaaaacacagcacucugcaaacacgaaaguggacguauagggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaacgauggcggcgcugucuccacccgagacucagugaaauugaaaucgcugugaagaugcaguguauccgcggcuagacggaaagaccccgugaaccuuuacuguagcuuugcacuggacuuugagccugcuuguguaggauaggugggaggcuuugaagcguggacgccaguucgcguggagccauccuugaaauaccacccuggcaugcuugagguucuaacucugguccguaauccggaucgaggacaguguauggugggcaguuugacuggggcggucuccuccuaaagaguaacggaggaguacgaaggugcgcucagaccggucggaaaucggucgcagaguauaaaggcaaaagcgcgcuugacugcgagacagacacgucgagcagguacgaaaguaggucuuagugauccggugguucuguauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaagccggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccguggacguuugagauuugagaggggcugcuccuaguacgagaggaccggaguggacgaaccucugguguuccgguugucacgccaguggcauugccggguagcuauguucggaaaagauaaccgcugaaagcaucuaagcgggaaacuugccucaagaugagaucucacugggaacuugauuccccugaagggccgucgaagacuacgacguugauaggcuggguguguaagcguugugaggcguugagcuaaccaguacuaauggcccgugaggcuugacc <<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<.<.<<<))).....>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...(((.....<<<<<<..<<<<<<.<<<...<<<.<......>.>>>((......<<<.....))>>>...>>>...>>>>>>..>>>>>>...........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<.....>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>...>.>>>...<<<.<<.<<........>>.>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<..<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<.......>>>..>>...>>>>.>>>..>>.>.....>>>>>.>>>>....>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<.........>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........)))......>>>>>>.>>>...>>>>>>><<<<<<......>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<....<<<.<<<<<<<..<<.....>>.>>>>>>>...>>>....>>>...>><..<<<<<<..>>>>>>...>>>>>>...>>>...>>>.>........>>>>...>>....>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<....<<..>>.....>>>>><<<<<<<<<<<<...<<<.....>>>....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.......<<<<<<.<<....>>..>>>>>>.......>>>>>>>>>..>>>>><<<.............>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<.<............<<<<....<...........<<........>>........>..............>>>>...>.>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<..<<.....<<<<....>>>>....>>...>>>>>.>>>...>>>>.....>>>>>>>. ..(((((......((((((((((.....(((..(((((((((((((......((((((.[[.[[[.))).....((((((...(((]]]..]].)))......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...(((.....((((((..(((.((.(((...(((.(......).)))[[(...).(((.....]])))...)))...)).)))..))))))...........((((((((..[......)))))))).......((((].[[[[))))...)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((.......))))..)))).[.(.(........).).((((((....(((((((((((((..((....((.....))....))...((....))..((((.....))))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.((.((.......<)).)))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..(((((((((.....(((....((.((((...((..(.(.....).)...))...)))).))...)).).....)))))).)))....))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.((...(((.........)))...)).....(..(..........)).)))))...)))..))))).))...........]]].)....))))))))))...)))))))(((((........)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((..((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((((((((.(...((((....((((..(((..(.(((.(((((....{{{...))))).((..(((....(((.((((((((.((.....))))))))))...)))..[.)))...))(..((((((()))))))...)))).)...)))...))))(..).....))))...).....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((...(((....])))....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))((((...........))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....))....(((((.....]..)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((((((((...((........[{..((((....(........(...((......))...).....)....]......}..))))...))...))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][..[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]..].....(((((((.(...]]]]...)))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....(((((((((.......)))))....((((((((..((.....((((....))))....))...))))).)))...))))..).))))))... 70S-PHIKZ014; 23S rRNA 8cd1 B 120 3.0 RF00001 URS00005ACE34_208964 38443577 0003735 0005840 208964 ugcuugacgaucauagagcguuggaaccaccugaucccuucccgaacucagaagugaaacgacgcaucgccgaugguaguguggggucuccccaugugagaguaggucaucgucaagcuc .<<<<<<<<<<....<<<<<.<.....<<<<<<...............>>>..>>>.....>>>>.>><<<.......<<<<<<<<...>>>>>>>>.......>>>.>>>>>>>>>>.. .((((((((......((....(.....(((((.(...(.....)...).))..)))....).....))..(.......((((((((...)))))))).......).....)))))))).. 70S-PHIKZ014; 5S rRNA 8cd1 Dt 76 3.0 RF00005 URS00005AA258_208964 38443577 0030533 0006412 208964 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((.........)))).....(((((..]....)))))))))))).... 70S-PHIKZ014; tRNA 8cd1 a 1526 3.0 RF01959,RF00177,RF02542,RF01960 URS000197CF85_208964 38443577 0003735 0005840 208964 aacugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgagcggauaaagggagcuugcuccuggauucagcggcggacgggugaguaaugccuaggaaucugccugguagugggggauaacguccggaaacgggcgcuaauaccgcauacguccugagggagaaagugggggaucuucggaccucacgcuaucagaugagccuaggucggauuagcuaguuggugggguaaaggccuaccaaggcgacgauccguaacuggucugagaggaugaucagucacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauuggacaaugggcgaaagccugauccagccaugccgcgugugugaagaaggucuucggauuguaaagcacuuuaaguugggaggaagggcaguaaguuaauaccuugcuguuuugacguuaccaacagaauaagcaccggcuaacuucgugccagcagccgcgguaauacgaagggugcaagcguuaaucggaauuacugggcguaaagcgcgcguaggugguucagcaaguuggaugugaaauccccgggcucaaccugggaacugcauccaaaacuacugagcuagaguacgguagagggugguggaauuuccuguguagcggugaaaugcguagauauaggaaggaacaccaguggcgaaggcgaccaccuggacugauacugacacugaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuagccguugggauccuugagaucuuaguggcgcagcuaacgcgauaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccuggccuugacaugcugagaacuuuccagagauggauuggugccuucgggaacucagacacaggugcugcauggcugucgucagcucgugucgugagauguuggguuaagucccguaacgagcgcaacccuuguccuuaguuaccagcaccucgggugggcacucuaaggagacugccggugacaaaccggaggaagguggggaugacgucaagucaucauggcccuuacggccagggcuacacacgugcuacaauggucgguacaaaggguugccaagccgcgagguggagcuaaucccauaaaaccgaucguaguccggaucgcagucugcaacucgacugcgugaagucggaaucgcuaguaaucgugaaucagaaugucacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcuccagaaguagcuagucuaaccgcaagggggacgguuaccacggagugauucaugacuggggugaagucguaacaagguagccguaggggaaccugcggcuggauc .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<....<<<<<<..>>>>>>....>>.>>>>>......<<.......<<<<<<<..<<...<<<<<<<<<.<<.....<<<<<<....>>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>>>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>...<.<<<<<......<<<<<<<<<<.......>>>>>>>>>>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<..<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>.>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<<..<<<......>>>.....>>>>>>>>.>..........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<.....>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<...<<<....>>>...>...<<<..>>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((....((((((..))))))....)).)))))......(((......(((((((..((...(((((((((.((.....((((((....))))))......)).).....(((....)))....((((((..((....))))))))))))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((.....(((....)))...)))).)).))))))..((((......((((....)))).....))))..((.(((((...(..((((((.(((.......))).))))))...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.((((((..((((((((((......((((((.....))))))....))))))))..)).))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((..((((.....))))..))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(...(((....)))...)...((....))..))))).))).((.((....((((((.(....((((((((......))...(((......)))...)))))).....((((.(((((.(...((..(((.....)))))....).))))).....(((((.....)))))........)))).....).).)))...))..))))....)))))))...)).)))))))).(...((((((......(((..((...(((....)))...))....)))......))))))......(....(((((((........)))))))....)..)..))))).....((((((...........))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... 70S-PHIKZ014; 16S rRNA 8cdl AA 3190 2.72 RF02543 URS000061F377_4932 38030725 0003735 0005840 4932 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80S S. cerevisiae ribosome with ligands in hybrid-2 pre-translocation (PRE-H2) complex; 25S ribosomal RNA 8cdl BB 121 2.72 RF00001 URS000055688D_4932 38030725 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<<............>>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). 80S S. cerevisiae ribosome with ligands in hybrid-2 pre-translocation (PRE-H2) complex; 5S ribosomal RNA 8cdl Bb 76 2.72 RF00005 URS000011107D_4932 38030725 0030533 0006412 4932 gcggauuuagcucaguugggagagcgccagacugaanaucuggagguccuguguucgauccacagaauucgcacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((........)))).(((((.......))))).....(((((.......)))))))))))).... 80S S. cerevisiae ribosome with ligands in hybrid-2 pre-translocation (PRE-H2) complex; Transfer RNA Phe 8cdl CC 158 2.72 RF00002 URS00001BF64E_4932 38030725 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... 80S S. cerevisiae ribosome with ligands in hybrid-2 pre-translocation (PRE-H2) complex; 5.8S ribosomal RNA 8cdl Cc 77 2.72 RF00005 URS000057545F_562 38030725 0030533 0006412 562 cgcgggguggagcagcccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(.((...].....)).)))))))..... 80S S. cerevisiae ribosome with ligands in hybrid-2 pre-translocation (PRE-H2) complex; Transfer RNA fMet 8cdl Dd 14 2.72 38030725 4932 aagaaaauguuuuu .............. .............. 80S S. cerevisiae ribosome with ligands in hybrid-2 pre-translocation (PRE-H2) complex; Messenger RNA 8cdl c 1604 2.72 RF01960,RF02542,RF01959,RF00177 URS000268149C_4932 38030725 0003735 0005840 4932 uaucugguugauccugccaguagucaunugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauacagugaaacugcgaauggcucnuuaaaucaguuaucguuuauuugauaguucccuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucagauguauuuauuagauugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauncaaggnaggcagcaggcgcgcnaauuacccaauccuaauucagggagguagugacaauaaauaacgauacauguaauuggaaugaguacaauguaaauaccuuaacgaggnacaauuggagggcaagucugnugccagcagccgcggnaauuccagcuccaauagcguauauuaaaguuguugcaguunaaaagcucguaguugaacuuugggcccgguugcaacggggccuuuccuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauungcauggaauaauagaauaggacguuuaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagancgaaaguuaggggaucgaagaugaucagauacngucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaangcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacncaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuuguggguggngnugcauggcnguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacangucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacnagnaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgnccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuucnguaggugnnccugcggaaggaucauu 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80S S. cerevisiae ribosome with ligands in hybrid-2 pre-translocation (PRE-H2) complex; 18S ribosomal RNA 8cdr AA 3197 2.04 RF02543 URS000061F377_4932 38030725 0003735 0005840 4932 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........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..<<<...<.......<<.<<<<<<...>>>>>>.>>.......>.....<<<<<<.<<<<<..<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>>..>>>>>......>>>>>>>>>>>........<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<....<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<<..>>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<...<<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>>.<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<..<.<<<<....<<<<<.....>>>>>..>>>>.>..>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<......<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>....>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>>..<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>.........<..<...........>..>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>...<...<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..[[[..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<<....>>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>...>......>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<....<....>.....>>>>><<.<<<<<<<<<<<.>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<..<<<<<<<<<<<<.<<<<<..........................................>>>>>>>.>>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))......<<<<<<<..<<<<.))))))>>>>>>>>>>>.........>>>>..>>>>>>.......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<....<<<<<<<<<<]]].>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<.<..<<<<<....>>>>>..>>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((.((((((.((((((((...({((((......)))))[[(...).(((....}]])))....))))))))...))).)))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((...(((((((((((((((((((((((.......(((((((......((((.(....).)))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).<((((........))))((((((....((((((.((((((..(((..((((.......))))..)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((....((.(((((((.....(((....(((..(.((((....(((.(.....).)))..)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....))).........(.(.............).)....))....))...(((((........)))))]]((((..(((((((...((((....)))...(.[[((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((.)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.((...(..((......(...[.....(......)..........)....]..))..)...)).)))))))....((((.....((((..((............))..........]]...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..))))))..)))))...)))....)))).)))))).))))).. Translocation intermediate 2 (TI-2) of 80S S. cerevisiae ribosome with ligands and eEF2 in the presence of sordarin; 25S ribosomal RNA 8cdr BB 121 2.04 RF00001 URS000055688D_4932 38030725 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<<............>>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Translocation intermediate 2 (TI-2) of 80S S. cerevisiae ribosome with ligands and eEF2 in the presence of sordarin; 5S ribosomal RNA 8cdr Bb 76 2.04 RF00005 URS000011107D_4932 38030725 0030533 0006412 4932 gcggauuuagcucaguugggagagcgccagacugaanaucuggagguccuguguucgauccacagaauucgcacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<.........>>>>>>>>>>>.... (((((((..((((........)))).(((((.......))))).....(((...........)))))))))).... Translocation intermediate 2 (TI-2) of 80S S. cerevisiae ribosome with ligands and eEF2 in the presence of sordarin; Transfer RNA Phe 8cdr CC 158 2.04 RF00002 URS00001BF64E_4932 38030725 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Translocation intermediate 2 (TI-2) of 80S S. cerevisiae ribosome with ligands and eEF2 in the presence of sordarin; 5.8S ribosomal RNA 8cdr Cc 77 2.04 RF00005 URS000057545F_562 38030725 0030533 0006412 562 cgcgggguggagcagcccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(((((.......)))))))))))..... Translocation intermediate 2 (TI-2) of 80S S. cerevisiae ribosome with ligands and eEF2 in the presence of sordarin; Transfer RNA fMet 8cdr c 1608 2.04 RF01960,RF02542,RF01959,RF00177 URS000268149C_4932 38030725 0003735 0005840 4932 uaucugguugauccugccaguagucaunugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauacagugaaacugcgaauggcucnuuaaaucaguuaucguuuauuugauaguucccuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucagauguauuuauuagauugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauncaaggnaggcagcaggcgcgcnaauuacccaauccuaauucagggagguagugacaauaaauaacgauacauguaauuggaaugaguacaauguaaauaccuuaacgaggnacaauuggagggcaagucugnugccagcagccgcggnaauuccagcuccaauagcguauauuaaaguuguugcaguunaaaagcucguaguugaacuuugggcccgguugcaacggggccuuucuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauungcauggaauaauagaauaggacguuuaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagancgaaaguuaggggaucgaagaugaucagauacngucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaangcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacncaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuuguggguggngnugcauggcnguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacangucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacnagnaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgnccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuucnguaggugnnccugcggaaggaucauu ...<<<<<.[.((((>>>>><<<<.<<<<<<...<.<...<......<<<.<<<..<<....<<....<<......>>...>>.>>......<<........<<<..<<..<<....<<<............<<......<<.<<.......>>.>>......>>........<<<<.>>>><...<<<<<<.............>>>>>>.....>...<<<<.<<<<.....>>>>>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>..>>>..>....>.>.....<<<<<<..>>>.>>>......<<.................>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>>>>>.........<<<((.....<.<<...<<<.<<....<<<<<<.<<<..>>>.>>>>>>.....<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........<<<.<.>.>>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<<.....>.>>>>>>>>>>>..>>>...<<..))>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<.......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<<<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<..<<<....>>>..>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>...>.>>>>>>>.....>.>>>>>....>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>......<....<<<<<<..........>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<..>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>........ 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Translocation intermediate 2 (TI-2) of 80S S. cerevisiae ribosome with ligands and eEF2 in the presence of sordarin; 18S ribosomal RNA 8ceh AA 3197 2.05 RF02543 URS000061F377_4932 38030725 0003735 0005840 4932 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Translocation intermediate 4 (TI-4) of 80S S. cerevisiae ribosome with ligands and eEF2 in the presence of sordarin; 25S ribosomal RNA 8ceh BB 121 2.05 RF00001 URS000055688D_4932 38030725 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Translocation intermediate 4 (TI-4) of 80S S. cerevisiae ribosome with ligands and eEF2 in the presence of sordarin; 5S ribosomal RNA 8ceh Bb 76 2.05 RF00005 URS000011107D_4932 38030725 0030533 0006412 4932 gcggauuuagcucaguugggagagcgccagacugaanaucuggagguccuguguucgauccacagaauucgcacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<.........>>>>>>>>>>>.... (((.(((..((((........)))).(((((.......))))).....(((...........)))))).))).... Translocation intermediate 4 (TI-4) of 80S S. cerevisiae ribosome with ligands and eEF2 in the presence of sordarin; Transfer RNA Phe 8ceh CC 158 2.05 RF00002 URS00001BF64E_4932 38030725 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Translocation intermediate 4 (TI-4) of 80S S. cerevisiae ribosome with ligands and eEF2 in the presence of sordarin; 5.8S ribosomal RNA 8ceh Cc 77 2.05 RF00005 URS000057545F_562 38030725 0030533 0006412 562 cgcgggguggagcagcccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(((((.......)))))))))))..... Translocation intermediate 4 (TI-4) of 80S S. cerevisiae ribosome with ligands and eEF2 in the presence of sordarin; Transfer RNA fMet 8ceh c 1608 2.05 RF01960,RF02542,RF01959,RF00177 URS000268149C_4932 38030725 0003735 0005840 4932 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...<<<<<.[.((((>>>>><<<<.<<<<<<...<.<...<......<<<.<<<..<<....<<....<<......>>...>>.>>......<<........<<<..<<..<<....<<<............<<......<<.<<.......>>.>>......>>.........<<<.>>>.<...<<<<<<.............>>>>>>.....>...<<<<.<<<<.....>>>>>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>..>>>..>....>.>.....<<<<<<..>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>>.........<<<((.....<.<<...<<<.<<....<<<<<<.<<<..>>>.>>>>>>.....<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........<<.......>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<<.....>.>>>>>>>>>>>..>>>...<<..))>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<......<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<..<<<....>>>..>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>.......>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>......<....<<<<<<..........>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<..>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>........ ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((......))...))[))......(((.......(((..((..((....(((........(...((......((.(((.....))).))......)).........(((.))).(.(.((((((....(......).)))))).)...)..)((((.((((.....))))))))....)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)....).).....((((((()))).)))....(.(.(..............)..)......)..((((([[....(.((((.....((..]])).......))))))))))..))))))))))..[......((([[...(.(.((...(((.((....(.((((.(((()))).)))).).....(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........((...()..)).....))...(((..((.((...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)).))...))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..((((((((.(((........)))))))))))..)))...((..]]))...))...].))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(......(((........((.(((........))).))......))).....((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..((((......((....))........))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...((.((())).))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}....... Translocation intermediate 4 (TI-4) of 80S S. cerevisiae ribosome with ligands and eEF2 in the presence of sordarin; 18S ribosomal RNA 8cep A 1046 2.04 RF00177,RF01959,RF02542,RF01960 URS000268143B_679895 37550453 0003735 0005840 679895 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaaugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaagcccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugccggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacggggguuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<.....>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<.>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<.....<<<<.....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<..>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.....>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((..).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((.)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((.....((((.....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((((())))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(..)))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Kasugamycin bound to the 30S body; 16S rRNA 8cep a 31 2.04 RF02541 URS00004B0F34_679895 37550453 0003735 0005840 679895 cggccguaacnauaacgguccuaagguagcg .<<<<<<.......>>>>>>........... .(((((.........)))))........... Kasugamycin bound to the 30S body; 23S rRNA 8ceu a 2753 1.83 RF02541 URS00004B0F34_679895 37550453 0003735 0005840 679895 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<<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<..>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<..>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>.>......>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<..>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((.(.((.....)).)..))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(())...)))..))))).))...........]]].)...))))))))))...)))))))((((((((()))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((())))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Retapamulin and Capreomycin bound to the 50S subunit; 23S rRNA 8ceu b 119 1.83 RF00001 URS0000049E57_679895 37550453 0003735 0005840 679895 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>> ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))) Retapamulin and Capreomycin bound to the 50S subunit; 5S rRNA 8cf2 A 11 NA URS0000BC466C_9606 38554107 32630 auacuuaccug ........... ........... Solution structure of the RNA helix formed by the 5'-end of U1 snRNA and an A-1 bulged 5'-splice site in complex with SMN-CY; RNA (5'-R(P*AP*UP*AP*CP*(PSU)P*(PSU)P*AP*CP*CP*UP*G)-3') 8cf2 B 11 NA URS0000BC4661_9606 38554107 32630 ggaguaagucu ........... ........... Solution structure of the RNA helix formed by the 5'-end of U1 snRNA and an A-1 bulged 5'-splice site in complex with SMN-CY; RNA (5'-R(P*GP*GP*AP*GP*UP*AP*AP*GP*UP*CP*U)-3') 8cf5 AA 3190 2.71 RF02543 URS000061F377_4932 38030725 0003735 0005840 4932 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugnaacnnggaccaaggagunuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccnanagauggugancuaugccugaauagggugaagccagaggaaacucugguggaggcucguancgguucugncgugcaaaucgaucgucgaaunuggguauagnggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcngaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaunuuggugguagunncaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaanguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucgcgaucaacuuagaacugguacggacaaggggaaucugacugucuaauunaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugccnagugcucugaaugucaaagugangaaauucaaccaagcgcggguaaacggcgggaguancuaugacucucuuaagguagcnannugccucnucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugunccuaucuacnaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcungacncuaguuugacauugugaagagacauagaggguguagaauaagugggagcuucggcgccagugaaauaccacuaccuuuauaguuucuuuacuuauucaaugaagcggagcuggaauuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcugnggcggcacaucugunaaacgnuaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauunucagngugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuanangugccagaaaaguuaccacagngauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuungaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggaunnuucacccacuaauagggaacgugngnuggguuuagancgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuugguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>...{.....<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<.<<<<<..<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>......>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]....}.............................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<....<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<..<.<<<<....<<<<<.....>>>>>..>>>>.>..>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>>..<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<..<...........>.>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>...<...<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<<....>>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>...>......>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<...............>>>>><<.<<<<<<<<<<<>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<<.<.<.<<<..........................................>>>.>>..>>>>>>>>>>...<<<<<.....<<<<..<<<<..>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<....>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((.(((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))).))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.(((((....(((((((((((((((((((((((.......(((((((......((((.(....).)))).......))))))).....))))).))))))))))........(((....)))....)))))))).....))))).))))).<((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...(.((.(.....).)).).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....))).........(.................)....))....))...(((((........)))))]]((((..(((.(((...((((....)))...(.[[((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....)))...))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.((((((((((()))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.....((.....((((....)))).....))..))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.((((((((..((((((((((.....(((..........................................))).....))))))))))....((((.....((((..((((()))))..........]]...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(((.((..)).)))..)))))...)))....)))).)))))).))))).. Translocation intermediate 1 (TI-1) of 80S S. cerevisiae ribosome with ligands and eEF2 in the presence of sordarin; 25S ribosomal RNA 8cf5 BB 121 2.71 RF00001 URS000055688D_4932 38030725 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Translocation intermediate 1 (TI-1) of 80S S. cerevisiae ribosome with ligands and eEF2 in the presence of sordarin; 5S ribosomal RNA 8cf5 Bb 76 2.71 RF00005 URS000011107D_4932 38030725 0030533 0006412 4932 gcggauuuagcucaguugggagagcgccagacugaanaucuggagguccuguguucgauccacagaauucgcacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((.(((..((((........)))).((((.........)))).....(((((.......)))))))).))).... Translocation intermediate 1 (TI-1) of 80S S. cerevisiae ribosome with ligands and eEF2 in the presence of sordarin; Transfer RNA Phe 8cf5 CC 158 2.71 RF00002 URS00001BF64E_4932 38030725 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<<<<....>>>>.....<.<<<......>>..............>>>..>...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Translocation intermediate 1 (TI-1) of 80S S. cerevisiae ribosome with ligands and eEF2 in the presence of sordarin; 5.8S ribosomal RNA 8cf5 Cc 77 2.71 RF00005 URS000057545F_562 38030725 0030533 0006412 562 cgcgggguggagcagcccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(.(((.......))).)))))))..... Translocation intermediate 1 (TI-1) of 80S S. cerevisiae ribosome with ligands and eEF2 in the presence of sordarin; Transfer RNA fMet 8cf5 Dd 13 2.71 38030725 4932 aagaaaauguuuu ............. ............. Translocation intermediate 1 (TI-1) of 80S S. cerevisiae ribosome with ligands and eEF2 in the presence of sordarin; Messenger RNA 8cf5 c 1604 2.71 RF01960,RF02542,RF01959,RF00177 URS000268149C_4932 38030725 0003735 0005840 4932 uaucugguugauccugccaguagucaunugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauacagugaaacugcgaauggcucnuuaaaucaguuaucguuuauuugauaguucccuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucagauguauuuauuagauugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauncaaggnaggcagcaggcgcgcnaauuacccaauccuaauucagggagguagugacaauaaauaacgauacauguaauuggaaugaguacaauguaaauaccuuaacgaggnacaauuggagggcaagucugnugccagcagccgcggnaauuccagcuccaauagcguauauuaaaguuguugcaguunaaaagcucguaguugaacuuugggcccgguugcaacggggccuuuccuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauungcauggaauaauagaauaggacguuuaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagancgaaaguuaggggaucgaagaugaucagauacngucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaangcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacncaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuuguggguggngnugcauggcnguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacangucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacnagnaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgnccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuucnguaggugnnccugcggaaggaucauu ...<<<<<.[.((((>>>>><<<<.<<<<<<...<.<...<......<<<.<<<..<<....<<....<<......>>...>>.>>......<<........<<<..<<..<<....<<<............<<......<<.<<.......>>.>>......>>........<<<<.>>>><...<<<<<<.............>>>>>>.....>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>..>>>..>....>.>.....<<<<<<..>>>.>>>......<<.................>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>>.........<<<((.....<.<<...<<<.<<....<<<<<<.<<<..>>>.>>>>>>.....<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........<<<.....>>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..))>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<<<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<...<<<<....>>>>.....>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>...>.>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>......<....<<<<<<..........>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<..>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>........ 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Translocation intermediate 1 (TI-1) of 80S S. cerevisiae ribosome with ligands and eEF2 in the presence of sordarin; 18S ribosomal RNA 8cg8 AA 3197 2.57 RF02543 URS000061F377_4932 38030725 0003735 0005840 4932 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Translocation intermediate 3 (TI-3) of 80S S. cerevisiae ribosome with ligands and eEF2 in the presence of sordarin; 25S ribosomal RNA 8cg8 BB 121 2.57 RF00001 URS000055688D_4932 38030725 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Translocation intermediate 3 (TI-3) of 80S S. cerevisiae ribosome with ligands and eEF2 in the presence of sordarin; 5S ribosomal RNA 8cg8 Bb 76 2.57 RF00005 URS000011107D_4932 38030725 0030533 0006412 4932 gcggauuuagcucaguugggagagcgccagacugaanaucuggagguccuguguucgauccacagaauucgcacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<.........>>>>>>>>>>>.... (((((((..((((........)))).(((((.......))))).....(((...........)))))))))).... Translocation intermediate 3 (TI-3) of 80S S. cerevisiae ribosome with ligands and eEF2 in the presence of sordarin; Transfer RNA Phe 8cg8 CC 158 2.57 RF00002 URS00001BF64E_4932 38030725 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Translocation intermediate 3 (TI-3) of 80S S. cerevisiae ribosome with ligands and eEF2 in the presence of sordarin; 5.8S ribosomal RNA 8cg8 Cc 77 2.57 RF00005 URS000057545F_562 38030725 0030533 0006412 562 cgcgggguggagcagcccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(.((.........)).)))))))..... Translocation intermediate 3 (TI-3) of 80S S. cerevisiae ribosome with ligands and eEF2 in the presence of sordarin; Transfer RNA fMet 8cg8 c 1608 2.57 RF01960,RF02542,RF01959,RF00177 URS000268149C_4932 38030725 0003735 0005840 4932 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...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((......))...))[))......(((.......(((..((..((....(((........(...((......((..((.....))..))......)).........(((.))).(.(.((((((....(......).)))))).)...)..)((((..(((.....))).))))....)))...))))..))).(((....((.....((((((((.......)))))))).))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)....).).....(((.((()))..)))....(.(.(..(..........))..)......)..((((([[....(.((((.....((..]])).......))))))))))..))))))))))..[......((([[...(.(.((...(((.((....(.((((.(((()))).)))).).....(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........((...()..)).....))...(((..((.((...((((..((..((((((.(...((........))......).))))))..)).......((....))...))))..)).))...))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..((((((((.(((........)))))))))))..)))...((..]]))...))...].))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))........(.(((((.(........(........((.(((........))).)).......)......((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..((((......((....))........))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).))))))..)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...((.((())).))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}....... Translocation intermediate 3 (TI-3) of 80S S. cerevisiae ribosome with ligands and eEF2 in the presence of sordarin; 18S ribosomal RNA 8cgd a 2748 1.98 RF02541 URS00004B0F34_679895 37550453 0003735 0005840 679895 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagcgucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaacc <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<<..>>>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<..>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<..>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<..>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>> ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((((..)))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((((.(.....).))).))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(..)...)))..))))).))...........]]].)...))))))))))...)))))))(((((((..)))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((..))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))) Clindamycin bound to the 50S subunit; 23S rRNA 8cgd b 119 1.98 RF00001 URS0000049E57_679895 37550453 0003735 0005840 679895 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>> ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))) Clindamycin bound to the 50S subunit; 5S rRNA 8cgj A 1130 1.79 RF00177,RF01959,RF02542,RF01960 URS000268143B_679895 37550453 0003735 0005840 679895 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggcucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaagcccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcgcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcagucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacaugacgucaacccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<..<.......>.>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<..>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<........<<....>>.......>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<..>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.........<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.................>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((.(........).))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((())))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......(.((....)).).....))))..((.(((((...(..(.(((.((((.......)))).))).)...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((()))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((..(.(....(((((((((....)))...(((......)))...))))))..........).)....)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Streptomycin bound to the 30S body; 16S rRNA 8cgj a 31 1.79 RF02541 URS00004B0F34_679895 37550453 0003735 0005840 679895 cggccguaacnauaacgguccuaagguagcg .<<<<<<.......>>>>>>........... .(((((.........)))))........... Streptomycin bound to the 30S body; 23S rRNA 8cgk a 2699 1.64 RF02541 URS00004B0F34_679895 37550453 0003735 0005840 679895 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<<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<<..>>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<.<....<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>..>>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<<..>>>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<......>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<................>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<......>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<..<<....>>...>>>>>.>.....>>>>>>>>>..>>>>>...........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<....>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>.(<<...<<<<<<<...<<..>>.....<<)..(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>> ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((......)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{........)))..))))).))...........]]].)...))))))))))...)))))))(((((......)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(.)........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((....)))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.((()))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))) Lincomycin and Avilamycin bound to the 50S subunit; 23S rRNA 8cgk b 39 1.64 RF00001 URS0000049E57_679895 37550453 0003735 0005840 679895 ccgcgaugguaguguggggucuccccaugcgagaguagg ...<.......<<<<<<<<...>>>>>>>>.......>. ...(.......((((((((...)))))))).......). Lincomycin and Avilamycin bound to the 50S subunit; 5S rRNA 8cgn AA 3197 2.28 RF02543 URS000061F377_4932 38030725 0003735 0005840 4932 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........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..<<<...........<<.<<<<<<...>>>>>>.>>.............<<<<<<.<<<<<.<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>>..>>>>>.>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<....<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<..<.<<<<....<<<<<.....>>>>>..>>>>.>..>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<......<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>....>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>>..<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<...<...........>..>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..[[[..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<<....>>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<.<<<<<<<<<<<.>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<..<<<<<<<<<<<<<..<<<..........................................>>>.>>>.>>>>>>>>>>...<<<<<.....<<<<..<<.<........>.>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))......<<<<<<<..<<<<.))))))>>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<....<<<<<<<<<<]]].>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<....>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((..((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))).).....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((...(((((((((((((((((((((((.......(((((((......(((((.(...)))))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).<((((........))))((((((....((((((.((((((..(((..((((.......))))..)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((....((.(((((((.....(((....(((..(.((((...((((.(.....).)))).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....))).........(.................)....))....))...(((((........)))))]]((((..(((((((...((((....)))...(.[[((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((.)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.((...(..((................(......)..................))..)...)).)))))))....((((.....((((..((............))..........]]...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..))))))..)))))...)))....)))).)))))).))))).. Non-rotated 80S S. cerevisiae ribosome with ligands; 25S ribosomal RNA 8cgn BB 121 2.28 RF00001 URS000055688D_4932 38030725 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<<............>>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Non-rotated 80S S. cerevisiae ribosome with ligands; 5S ribosomal RNA 8cgn Bb 77 2.28 RF00005 URS000057545F_562 38030725 0030533 0006412 562 cgcgggguggagcagcccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....((((.........))))))))))..... Non-rotated 80S S. cerevisiae ribosome with ligands; Transfer RNA fMet 8cgn CC 158 2.28 RF00002 URS00001BF64E_4932 38030725 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Non-rotated 80S S. cerevisiae ribosome with ligands; 5.8S ribosomal RNA 8cgn Cc 77 2.28 RF00005 URS000057545F_562 38030725 0030533 0006412 562 cgcgggguggagcagcccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....((((.........))))))))))..... Non-rotated 80S S. cerevisiae ribosome with ligands; Transfer RNA fMet 8cgn c 1624 2.28 RF01960,RF02542,RF01959,RF00177 URS000268149C_4932 38030725 0003735 0005840 4932 uaucugguugauccugccaguagucaunugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauacagugaaacugcgaauggcucnuuaaaucaguuaucguuuauuugauaguucccuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucagauguauuuauuagauaaugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauncaaggnaggcagcaggcgcgcnaauuacccaauccuaauucagggagguagugacaauaaauaacgauacauguaauuggaaugaguacaauguaaauaccuuaacgaggnacaauuggagggcaagucugnugccagcagccgcggnaauuccagcuccaauagcguauauuaaaguuguugcaguunaaaagcucguaguugaacuuugggcccgguugcaacggggccuuucuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauungcauggaauaauagaauaggacguuugguucuauaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagancgaaaguuaggggaucgaagaugaucagauacngucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaangcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacncaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuuguggguggngnugcauggcnguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacangucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacnagnaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgnccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuucnguaggugnnccugcggaaggaucauu ...<<<<<.[.((((>>>>><<<<.<<<<<<...<.<...<......<<<.<<<..<<....<<....<<......>>...>>.>>......<<........<<<..<<..<<....<<<............<<......<<.<<.......>>.>>......>>........<<<<.>>>><...<<<<<<...............>>>>>>.....>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>..>>>..>....>.>.....<<<<<<..>>>.>>>......<<..<...........>..>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>>>>>.........<<<((.....<.<<...<<<.<<....<<<<<<.<<<..>>>.>>>>>>.....<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........<<<..<<<<<<<..>>>>>>>.>>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>......<<<....>>>..>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<<.....>.>>>>>>>>>>>..>>>...<<..))>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<<<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<.<<<<....>>>>.>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>...>.>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>......<....<<<<<<..........>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<..>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>........ ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((......))...))[))......(((.......(((..((..((....(((........(...((......((.(((.....))).))......))........((((.))))(.(.((((((......(......).)))))).)...)..)((((...((.....))..))))....)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)....).).....(.((((()))).).)....(.(.(.(...........))..)......)..((((([[....(.((((.....((..]])).......))))))))))..))))))))))..[......((([[...(.(.((...(((.((....(.((((.(((()))).)))).).....(((((.((.(.....((..((.......)).(((.....)))....))..)...)).))..))).........(((..(((((((()))))))).))).....))...(((..((.((...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)).))...))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..((((((((.(((........)))))))))))..)))...((..]]))...))...].))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....((((.........((.(((........))).)).......))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..((((......((....))........))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...(((((())))))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}....... Non-rotated 80S S. cerevisiae ribosome with ligands; 18S ribosomal RNA 8cgr A 1060 2.12 RF00177,RF01959,RF02542,RF01960 URS000268143B_679895 37550453 0003735 0005840 679895 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaagcccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugccggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacggggguuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<.<....>.>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<.>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<.....<<<<.....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.<...>.>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<..>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.....>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((........))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....(((((...))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((.....((((.....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((((..)))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(..)))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Apramycin bound to the 30S body; 16S rRNA 8cgr a 30 2.12 RF02541 URS00004B0F34_679895 37550453 0003735 0005840 679895 ggccguaacnauaacgguccuaagguagcg <<<<<<.......>>>>>>........... (((((.........)))))........... Apramycin bound to the 30S body; 23S rRNA 8cgu A 1047 1.89 RF00177,RF01959,RF02542,RF01960 URS000268143B_679895 37550453 0003735 0005840 679895 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaauugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaagcccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugccggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacggggguuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<.>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<.>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<.....<<<<.....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<..>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.....>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((.)).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((.)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((.....((((.....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((((())))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(..)))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Gentamicin bound to the 30S body; 16S rRNA 8cgu a 31 1.89 RF02541 URS00004B0F34_679895 37550453 0003735 0005840 679895 cggccguaacnauaacgguccuaagguagcg .<<<<<<.......>>>>>>........... .(((((.........)))))........... Gentamicin bound to the 30S body; 23S rRNA 8cgv a 2687 1.66 RF02541 URS00004B0F34_679895 37550453 0003735 0005840 679895 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<<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<...>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<....>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<..>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<..>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<..<<....>>...>>>>>..>....>>>>>>>>>..>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<..>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<.>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...(((...)))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((....)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{........)))..))))).))...........]]].)...))))))))))...)))))))((((((((()))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((())))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(.)...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Tiamulin bound to the 50S subunit; 23S rRNA 8cgv b 56 1.66 RF00001 URS0000049E57_679895 37550453 0003735 0005840 679895 cggccguagcgcagcgccgaugguaguguggggucuccccaugcgagaguagggaa ........<<...>>.<<.......<<<<<<<<...>>>>>>>>.......>>... ........((...)).((.......((((((((...)))))))).......))... Tiamulin bound to the 50S subunit; 5S rRNA 8ch6 d 93 5.9 RF00026 URS000035C796_9606 37165190 0030621 0000244,0000353 0005688,0046540 9606 gugcucgcuucggcagcacauauacuaaaauuggaacgauacagagaagauuagcauggccccugcgcaaggaugacacgcucgugaagcguu <<<<<.<<<..>>>>>>>>.....................................<<...<<<.....>>>....>>............... (((((.((....))))))).....................................((..((((.....)))..).))............... Structure of a late-stage activated spliceosome (BAqr) arrested with a dominant-negative Aquarius mutant (state B complex).; RNU6-1 8ch6 e 98 5.9 RF00020 URS000075BAAE_9606 37165190 0000244,0000353 0005682,0046540 9606 gguuucucuucagaucgcauaaaucuuucgccuuuuacuaaagauuuccguggagaggaacaaucugagauuuuuugaggccuugcuuuggcaaggcu .<<<<<<<<<<.........<<<<<<<<...........>>>>>>>>....>>>>>>>>>>.................<<<<<<<......>>>>>>> .((((((((((....((...((((((((.(.......).)))))))).)).)))))))))).................(...(((......)))...) Structure of a late-stage activated spliceosome (BAqr) arrested with a dominant-negative Aquarius mutant (state B complex).; RNU5A-1 8ch6 f 137 5.9 RF00004 URS00003EE995_9606 37165190 0045131 0000348 0005686 9606 aucgcuucucggccuggcuaagaucaaguguaguaucuguucuuaucaguuuaauaucugauguccucucgaggacggauuuuuggagcagggagccacgcaucgaccugguauugcaguaccuccaggaacggugc .............................................<<<..........>>>...<<<<..>>>>.................<......><<<<<<.<<<<<.............>>>>>..>>>>>> .............................................(((..........)))...((((..)))).................(......)((((((.(((((.............)))))..)))))) Structure of a late-stage activated spliceosome (BAqr) arrested with a dominant-negative Aquarius mutant (state B complex).; RNU2-1 8ch6 g 76 5.9 URS00026813FC_10535 37165190 10535 ucggccuccgaacgguaagagccuagcauguagaacugguuaugaugucauacuuauccugucccuuuuuuuucca ............................................................................ ............................................................................ Structure of a late-stage activated spliceosome (BAqr) arrested with a dominant-negative Aquarius mutant (state B complex).; MINX-M3 8civ AA 3197 2.47 RF02543 URS000061F377_4932 38030725 0003735 0005840 4932 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........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[...<.......<<.<<<<<<...>>>>>>.>>.......>.....<<<<<<.<<<<<..<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>......>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<....<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<....<<<<<<...>>>>>>..>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<......<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>....>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>>..<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>.........<................>.....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<<....<<<....>>>...<...<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<<....>>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>...>.....>>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<.<<<<<<<<<<<.>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<<<<...<<<..........................................>>>..>>.>>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<....>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((..(.((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))..).....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((...(((((((((((((((((((((((.......(((((((......((((..(...).)))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).<((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))..).))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((((((((((....((.(((((((.....(((....(((..(.((((...((((((.....)))))).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.((.((.....)).)).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....))).........(.................)....))....))...(((((........)))))]]((((..(((((((...((((....)))...(.[[((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((.)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.(((.....((......(.........(......)..........).......))....).)).)))))))....((((.....((((..((............))..........]]...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..))))))..)))))...)))....)))).)))))).))))).. Translocation intermediate 5 (TI-5) of 80S S. cerevisiae ribosome with ligands and eEF2 in the presence of sordarin; 25S ribosomal RNA 8civ BB 121 2.47 RF00001 URS000055688D_4932 38030725 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Translocation intermediate 5 (TI-5) of 80S S. cerevisiae ribosome with ligands and eEF2 in the presence of sordarin; 5S ribosomal RNA 8civ Bb 76 2.47 RF00005 URS000011107D_4932 38030725 0030533 0006412 4932 gcggauuuagcucaguugggagagcgccagacugaanaucuggagguccuguguucgauccacagaauucgcacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<.........>>>>>>>>>>>.... (((((((..((((........)))).(((((.......))))).....(((...........)))))))))).... Translocation intermediate 5 (TI-5) of 80S S. cerevisiae ribosome with ligands and eEF2 in the presence of sordarin; Transfer RNA Phe 8civ CC 158 2.47 RF00002 URS00001BF64E_4932 38030725 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Translocation intermediate 5 (TI-5) of 80S S. cerevisiae ribosome with ligands and eEF2 in the presence of sordarin; 5.8S ribosomal RNA 8civ Cc 77 2.47 RF00005 URS000057545F_562 38030725 0030533 0006412 562 cgcgggguggagcagcccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(.((.........)).)))))))..... Translocation intermediate 5 (TI-5) of 80S S. cerevisiae ribosome with ligands and eEF2 in the presence of sordarin; Transfer RNA fMet 8civ c 1622 2.47 RF01960,RF02542,RF01959,RF00177 URS000268149F_4932 38030725 0003735 0005840 4932 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Translocation intermediate 5 (TI-5) of 80S S. cerevisiae ribosome with ligands and eEF2 in the presence of sordarin; 18S ribosomal RNA 8cku AA 3190 3.11 RF02543 URS000061F377_4932 38030725 0003735 0005840 4932 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........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((.(((...))).)).))....)........((((((.(((((.(((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..)))).)))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.(((((....(((((((((((((((((((((((.......(((((((.......(((.(....).)))........))))))).....))))).))))))))))........(((....)))....)))))))).....))))).))))).<((((........))))((((((....((((((.((((((..(((..((((.......))))..)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((....((.(((((((.....(((....(((..(.((((.....((.........))...))))..).)))..)).).....)))))...((((..(((.(......))))..)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....))).........(.(.............).)....))....))...(((((........)))))]]((((..(((.(((...((((....)))...(.[[((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....).(((((((....))))))).)))).).))))))).))))(...)....))))))...))....)))...))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.((((((((.(..).))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.((.(((((..(..((((.((......((..........................................))......)).))))..)....((((.....((((...((....))...........]]...((((((....))))))..))))..))))......))))).))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a.))..))).))))).....(((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))........((((((.(((.((....((.(........((((.((..).).)))).....))).......((((((....((((.(..(((......)))..).))))..)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.((.....((((.(..((((((..))))))..)))))....))....)))).)))))).))))).. Translocation intermediate 1 (TI-1*) of 80S S. cerevisiae ribosome with ligands and eEF2 in the absence of sordarin; 25S ribosomal RNA 8cku BB 121 3.11 RF00001 URS000055688D_4932 38030725 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Translocation intermediate 1 (TI-1*) of 80S S. cerevisiae ribosome with ligands and eEF2 in the absence of sordarin; 5S ribosomal RNA 8cku Bb 76 3.11 RF00005 URS000011107D_4932 38030725 0030533 0006412 4932 gcggauuuagcucaguugggagagcgccagacugaanaucuggagguccuguguucgauccacagaauucgcacca <<<<<<<..<<<<........>>>>.<<.<<.......>>.>>.....<<<<<.......>>>>>>>>>>>>.... ((((.((..((((........)))).((.(.........).)).....(((((.......))))))).)))).... Translocation intermediate 1 (TI-1*) of 80S S. cerevisiae ribosome with ligands and eEF2 in the absence of sordarin; Transfer RNA Phe 8cku CC 158 3.11 RF00002 URS00001BF64E_4932 38030725 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<(.....>>............).>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Translocation intermediate 1 (TI-1*) of 80S S. cerevisiae ribosome with ligands and eEF2 in the absence of sordarin; 5.8S ribosomal RNA 8cku Cc 77 3.11 RF00005 URS000057545F_562 38030725 0030533 0006412 562 cgcgggguggagcagcccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(.(((.......))).)))))))..... Translocation intermediate 1 (TI-1*) of 80S S. cerevisiae ribosome with ligands and eEF2 in the absence of sordarin; Transfer RNA fMet 8cku Dd 13 3.11 38030725 4932 aagaaaauguuuu ............. ............. Translocation intermediate 1 (TI-1*) of 80S S. cerevisiae ribosome with ligands and eEF2 in the absence of sordarin; Messenger RNA 8cku c 1604 3.11 RF01960,RF02542,RF01959,RF00177 URS000268149C_4932 38030725 0003735 0005840 4932 uaucugguugauccugccaguagucaunugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauacagugaaacugcgaauggcucnuuaaaucaguuaucguuuauuugauaguucccuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucagauguauuuauuagauugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauncaaggnaggcagcaggcgcgcnaauuacccaauccuaauucagggagguagugacaauaaauaacgauacauguaauuggaaugaguacaauguaaauaccuuaacgaggnacaauuggagggcaagucugnugccagcagccgcggnaauuccagcuccaauagcguauauuaaaguuguugcaguunaaaagcucguaguugaacuuugggcccgguugcaacggggccuuuccuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauungcauggaauaauagaauaggacguuuaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagancgaaaguuaggggaucgaagaugaucagauacngucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaangcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacncaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuuguggguggngnugcauggcnguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacangucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacnagnaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgnccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuucnguaggugnnccugcggaaggaucauu ...<<<<<.[.((((>>>>><<<<.<<<<<<...<.<..........<<<.<<<..<<....<<....<<......>>...>>.>>......<<..<.....<<<..<<..<<....<<<............<<......<<.<<.......>>.>>......>>........<<<<.>>>><...<<<<<<.............>>>>>>.....>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>>>>.<<.<<<..........>>>.>>.<.<<<..>>>.>...>>>>>>.........<<<....<<<.....>>>..>>>.......>.>.....<<<.<....>..>>>......<<.................>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>>>>>.........<<<((.....<.<<...<<<.<<....<<<<<<.<<<..>>>.>>>>>>.....<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........<<<.....>>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>..>.>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..))>>...>>.....>>>.>>>.<<<......<<<......>>>....>>>..)))).]<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>............<<<<<..........>>>>>...........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<....>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>........ 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Translocation intermediate 1 (TI-1*) of 80S S. cerevisiae ribosome with ligands and eEF2 in the absence of sordarin; 18S ribosomal RNA 8cmj AA 3197 3.79 RF02543 URS000061F377_4932 38030725 0003735 0005840 4932 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Translocation intermediate 4 (TI-4*) of 80S S. cerevisiae ribosome with eEF2 in the absence of sordarin; 25S ribosomal RNA 8cmj BB 121 3.79 RF00001 URS000055688D_4932 38030725 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. ((((((.((....((((((((......(((((...(....)...))).)..).....)))))).))((((((.......(((((..((....)).))))).....)))))))).)))))). Translocation intermediate 4 (TI-4*) of 80S S. cerevisiae ribosome with eEF2 in the absence of sordarin; 5S ribosomal RNA 8cmj CC 158 3.79 RF00002 URS00001BF64E_4932 38030725 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<<<<....>>>>.....<.<<<......>>..............>>>..>...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Translocation intermediate 4 (TI-4*) of 80S S. cerevisiae ribosome with eEF2 in the absence of sordarin; 5.8S ribosomal RNA 8cmj c 1608 3.79 RF01960,RF02542,RF01959,RF00177 URS000268149C_4932 38030725 0003735 0005840 4932 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Translocation intermediate 4 (TI-4*) of 80S S. cerevisiae ribosome with eEF2 in the absence of sordarin; 18S ribosomal RNA 8cq7 1 3216 3.2 RF02540,RF02541,RF02543 0003735 0005840 5476 ugaccucaaaucagguaggacuacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaacagggauugccucaguagcggcgagugaagcggcaaaagcucaaauuugaaaucuggcgucuuuggcguccgaguuguaauuugaagaagguaucuuugggcccggcucuugucuauguuccuuggaacaggacgucacagagggugagaaucccgugcgaugagaugacccgggucuguguaaaguuccuucgacgagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcuugagaucagacuugguauuuugcaugcgguuuaccgggccagcaucgguuuggagcggcaggauaauggcggaggaauguggcacggcuucugcuguguguuauagccucugacgauacugccagccuagaccgaggacugcgguuuaccuaggauguuggcauaaugaucuuaagucgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccguacgcguaaugaaagugaacgaaggugggggcccauuagggugcaccaucgaccgauccugauguguucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagaagucuugggguugaaaugaccuuaacuuauucucaaacuuuaaauauguaagaaguccuuguugcuuaauugaacguggacaauugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacgugaaguuaaagugccggaaugcacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcgugcuacuuauacuucaccgugauugcuguuuugacgcuuucacgaguaggcaggcguggaggucagugacgaagccuuugcuguaaagcugggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccaugucaacagcaguuggacauggguuagucgauccuaagagauggggaagcuccguuucaacgugcuugauuuuucaggccaaccaucgaaagggaauccgguuaaaauuccggaacuuggauauggauucuucacggcaacguaacugaauguggagacgucggcgugagcccugggaggaguuaucuuuucuucuuaacagcuuaucacccuggaauugguuuauccggagauggggucuuauggcuggaagagcgcgguaauuuugccgcguccggugcgcuuacgacgguccuugaaaauccacaggaaggaauaguuuucaugccaagucguacucauaaccgcagcaggucuccaagguuaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaaggaucgguuuaacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugugauggucagaaagugauguugacacaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaaaagacauggaggguguagaauaagugggagcuucggcgccggugaaauaccacuaccucuauaguuuuuuuacuuauucaaugaagcggagcuggaggucaaacuccacguucuagcauuaagcccucugggcgauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagguguccuaagggggacucauggagaacagaaaucuccaguagaacaaaaggguaaaaguccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaucgcaauaguaauugaacuuaguacgagaggaaccguucauucagauaauugguuuuugcggcugucugaucaggcaacgccgcgaagcuaccaucugcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcgaugauuuuugcccugcacauuuuagauggauacgaauaagacuuuuuagucgcuggaccauagcaggcuggcaacggugcgcuuagcggaaaggcuuugugcgcuugccggcggauagcaaugucaacaugcgcggggauaaauccuuugcauacgacuuagauguacaacggaguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagcucuuguugucugauuugu .......................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<.......>.....>>>>>..[[[...........<<.<<<<<<...>>>>>>.>>.............<<<<<...<<<<<<<<<<<<.<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>....>>>>>>>>....>>>>..>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<<<<<.....<<<<..<<<<..>>>>..>>>>..<<<<<<<.<<<<<<<<.<<<<<<<....<<.<<<<<<<......<<<<<<......>>>>>>.......>>>>>>.>.>>.>>>>>.>>>>>>>>>>........<<<..>>>.....>>>>>>>....>>>>>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<..<<<<<.....>>>>>..>>>...<<....>>.......<<<<<..<<<<....>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<.......>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<..<<.........>>..>>>>>....>>>>>>..<<<<<<<<.<<......<<<<..<<<....>>>.>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<<<<<....>>>>>>......>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<...............>>>>><<.<<<<<<<<<<<......>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<<...<.<<............................................>>.>...>>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>..............<<<<...>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<.................>>>>>..<<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.....<<<<<<.<<<.<.....<<..........<<<......>>>......>>.......<<<<<<...<<<<<<<..<<<......>>>..>>>>>>>.>>>>>>..............>.>>>.>>>>>>..<<<<<<<.............>>....<<<<<<<<<.<<<....<<<<.<..<<<<<......>>>>>..>>>>>...>>>....>>>>.>>>>>..>>>>>.. .......................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........(((((...((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))).)..))))))))....))))..)))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((((((..(..((((..((((()))))..))))).((((((((((((((((.(((((((........((((((......((((((......)))))).......))))))......))))).))))))))))........(((..)))....))))))))....)))))))))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..((((....))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((........)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((....((.(((((((.....(((....(((..(.((((...((((.(.....).)))).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((..((.........))..)))))....))))))(.((((((((.((......((((..(((....))).))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........(.((.((......)).))).....))....))...(((((........)))))]]((((..(((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((......)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(..(((.....((((....)))).....))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.((....(.(.............(...(......)...............)...)..)...)).)))))))....((((.....((((..(((((......)))))...........>..((((...))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))....))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).....((((((.(((.......((.(........(((......))).....))).......((((((...(((((((..(((......)))..))))))).))))))................))).))))))..(((((((..(.......)..))..(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Crystal structure of phyllanthoside bound to the Candida albicans 80S ribosome; 25S 8cq7 3 121 3.2 RF00001 0003735 0005840 5476 gguugcggccauaucuagcagaaagcaccguuccccguucgaucaaccguaguuaagcugcuaagagcaauaccgaguaguguagugggagaccauacgcgaaacuauugugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of phyllanthoside bound to the Candida albicans 80S ribosome; 5S 8cq7 4 157 3.2 RF00002 URS0000082EA4_5476 0003735 0005840 5476 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaauaugaauugcagauauucgugaaucaucgaaucuuugaacgcacauugcgcccucugguauuccggagggcaugccuguuugagcgucguu .........................................<<<<<<.((.....>>>.....<.<<<<.....))............>>.>>..>...>>>....<<.....>><<<<<<<<<....>>>>>>>>>.................... .........................................((((((.[[.....))).....(.((((.....]]............)).))..)...)))....((.....))(((((((((....))))))))).................... Crystal structure of phyllanthoside bound to the Candida albicans 80S ribosome; 5.8S 8cq7 B 1756 3.2 RF01960,RF02542,RF01959,RF00177 0003735 0005840 5476 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguaccuuacuacuuggauaaccgugguaauucuagagcuaauacaugcuuaaaaucccgacuguuuggaagggauguauuuauuagauaaaaaaucaaugccuucgggcucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaaucccgacacggggagguagugacaauaaauaacgauacagggcccuuuugggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaaaagcguauauuaaaguuguugcaguuaaaaagcucguaguugaaccuugggcuuggcuggccgguccgcguacuggacccagccgagccuuuccuucuggguagccauuuauggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggccuuugcucgaauauauuagcauggaauaauagaauaggacguuaugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucggggguaucaguauucaguugucagaggugaaauucuuggauuuacugaagacuaacuacugcgaaagcauuuaccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgguuguuguucuuuuauugacgcaaucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauagugcugcuagcauuugcugguauagucacuucuuagagggacuaucgauuucaagucgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgaguauaagccuuggccgagaggucugggaaaucuugugaaacuccgucgugcuggggauagagcauuguaauuguugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuacuaccgauugaauggcuuagugaggccuccggauugguuuauucuggaaccgagaagcuggucaaacuuggucauuuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucau ...<<<<<.{.((((>>>>><<<<.<<<<<<...<.<...<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<..<<..<<....<<<...............<<.....<..<<.......>>..>......>>........<<<<<..<<....>>..>>>>><...<<<<<<.......{.((((.<<<....>>>..............>>>>>>.....>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>....>.>.....<<<<<<<<.<<<<....>>>>.>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>>.........<<<[[.....<.<<...<<<.<<....<<<<<<<<<<......................>>>>>>>>>>.....<<<<....................>>>>....<<<<<.<<.......<<...<.......>..<<<....>>>....>>......>>.>>..>>>.........<<<..<<<<<<<<......)))).}...>>>>>>>>>>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<..<<........>>.>>>>>>>>..>>>...<<..]]>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..)))).}<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<.....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<.<<<<<<<....>>>>>>>....>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>.....>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<......<<<.<<<<....>>>>.>>>....>>.......>>>>>>>......<....<<<<<<..........>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<..<...<<<<<<........>>>>>>...>..>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>....... ....(((..[.[[[..))).((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((...............((.....(..(((.....)))..)......))........(((((..((....))..)))))(.(.(((((........[[.[[..(((....))).....(......)..))))).)...).(..(((..((((..).))).))).)...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(((((((.(((((....))))).)))).)))......(.(.(...........))..).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....(((((.((((.......(...)..........)))).))))).....((((....................))))....(((((.((.(.....((..((.......)).(((....)))....))..)...)).))..))).........(((..(((((.((.......]]..]]..)).)))))))).....))....((..((.((...((((...(..((((((.....((........))........))))))..)........((....))...))))..)).))...))...)))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((..(..........).))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.........(.(((........))).).......)))))...((.(((...(..((((.....(((.(((((....)))..(.((......)))...)).)))....(((((.((...(((..((((.(.(((((....))))).)....))))..)))..))..(.((((((.....))))))....)..))))).....)).))......).))))).....).)))))...)).)))).))).(...(((((((......((......(((.((((....)))).)))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..((((..(...(((((..........)))))...)..))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>...... Crystal structure of phyllanthoside bound to the Candida albicans 80S ribosome; 18S 8cq7 AS 3222 3.2 RF02540,RF02541,RF02543 0003735 0005840 5476 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.......................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........(((((...((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))).)..))))))))....))))..)))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((((((..(..((((...((((.()...))))...))))).((((((((((((((((.(((((((........((((((......((((.(......).)))).......))))))......))))).))))))))))........(((....)))....))))))))....)))))))))))).<((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..((((....))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((....((.(((((((.....(((....(((..(.((((....((((.......))))..)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{..((((.(((...((.........))...))).....(...((......)).).))))....)))))))))))))..........]]].)....))))))))))...)))))))(((((..((.........))..)))))....))))))(.((((((((.((......((((..(((....))).))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........(.((.((......)).))).....))....))...(((((........)))))]]((((..(((((((...((((....)))...(.[[((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((....)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(..(((.....((((....)))).....))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.((((((((..((((((((((((......................(......).......................)).))))))))))....((((.....((((..(((((......)))))..........]]..((((...))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).....((((((.(((.......((.(........((((....)))).....))).......((((((...(((((((..(((......)))..))))))).))))))................))).))))))..(((((((..(.......)..))..(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Crystal structure of phyllanthoside bound to the Candida albicans 80S ribosome; 25S 8cq7 AT 121 3.2 RF00001 0003735 0005840 5476 gguugcggccauaucuagcagaaagcaccguuccccguucgaucaaccguaguuaagcugcuaagagcaauaccgaguaguguagugggagaccauacgcgaaacuauugugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<<............>>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of phyllanthoside bound to the Candida albicans 80S ribosome; 5S 8cq7 AU 158 3.2 RF00002 0003735 0005840 5476 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaauaugaauugcagauauucgugaaucaucgaaucuuugaacgcacauugcgcccucugguauuccggagggcaugccuguuugagcgucguuu .........................................<<<<<<.((.....>>>.....<.<<<<.....))............>>.>>..>...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............)).))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of phyllanthoside bound to the Candida albicans 80S ribosome; 5.8S 8cq7 CM 1765 3.2 RF01960,RF02542,RF01959,RF00177 URS000059AE3B_5476 0003735 0005840 5476 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...<<<<<.{.((((>>>>><<<<.<<<<<<...<.<...<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<..<<..<<....<<<...............<<.....<..<<.......>>..>......>>........<<<<<..<<....>>..>>>>><...<<<<<<.........((((.<<<....>>>..............>>>>>>.....>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>....>.>.....<<<<<<<<<<<<.....>>.>>>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>>.........<<<[[.....<.<<...<<<.<<....<<<<<<<<<<.........<..>.............>>>>>>>>>>.....<<<<....................>>>>....<<<<<.<<.......<<...<.......>..<<<....>>>....>>......>>.>>..>>>.........<<<..<<<<<<<<<.....))))....>>>>>>>>>>>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<..<<........>>.>>>>>>>>..>>>...<<..]]>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..)))).}<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<.....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<.<<<<<<<....>>>>>>>....>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>.....>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<......<<<.<<<<....>>>>.>>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<..<...<<<<<<<.<.<...>.>.>>>>>>>...>..>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>....... ....(((..[.[[[..))).((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((...............((.....(..(((.....)))..)......)).........((((..((....))..)))).(.(.(((((.........[.[[[.(((....))).....(......)..))))).)...).(..(((..((((..).))).))).)...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(((((((.(((.......).)).)))).)))....(.(.(.(...........))..)......)..((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....(((((.((((....(..(..().)....).......)))).)))))......((((..................)))).....(((((.((.(.....((..((.......)).(((....)))....))..)...)).))..))).........(((..(((((.((......]]]...]..)).)))))))).....))....((..((..(...((((...(..((((((.....((........))........))))))..)........((....))...))))..)..))...))...)))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((..(..........).))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.........(.(((........))).).......)))))...((.(((...(..((((.....(((.(((((....)))..(.((......)))...)).)))....(((((.((...(((..((((((.(((((....))))).)..).))))..)))..))..(.((((((.....))))))....)..))))).....)).))......).))))).....).)))))...)).)))).))).(...(((((((......((......(((.((((....)))).)))....)).......)))))))......(....((((((..........))))))....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..((((..(...((((((.............))))))...)..))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>...... Crystal structure of phyllanthoside bound to the Candida albicans 80S ribosome; 18S 8cqw 1 3208 3.05 RF02540,RF02541,RF02543 0003735 0005840 5476 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.......................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[...........<<.<<<<<<...>>>>>>.>>.............<<<<<...<<<<<<<<<<<<.<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>....>>>>>>>>....>>>>..>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]................................<.<<....>>...>...........<<<<....>>>>..................................<<<<<<<<<<<<.....<<<<..<.....>..>>>>..<<<<<<<.<<<<<<<<.<<<<<<<....<<.<<<<<<<......<<<<<<......>>>>>>.......>>>>>>.>.>>.>>>>>.>>>>>>>>>>........<<<.>>>.....>>>>>>>....>>>>>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<..<<<<<.....>>>>>..>>>...<<....>>.......<<<<<..<<<<....>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<..<<.........>>..>>>>>....>>>>>>..<<<<<<<<.<<......<<<<..<<<....>>>.>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<<<<<....>>>>>>......>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<....<....>.....>>>>><<.<<<<<<<<<<<......>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<<...<.<<........................................>>.>...>>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>..............<<<<...>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<.................>>>>>..<<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.....<<<<<<.<<<.<.....<<..........<<<......>>>......>>.......<<<<<<...<<<<<<<..<<<......>>>..>>>>>>>.>>>>>>..............>.>>>.>>>>>>..<<<<<<<.............>>....<<<<<<<<<.<<<....<<<<.<..<<<<<......>>>>>..>>>>>...>>>....>>>>.>>>>>..>>>>>.. .......................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........(((((...((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))).)..))))))))....))))..)))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((((((..(..((((..((...))..))))).((((((((((((((((.(((((((........((((((......((((((......)))))).......))))))......))))).))))))))))........(((.)))....))))))))....)))))))))))).<((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..((((....))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((........)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((....((.(((((((.....(((....(((..(.((((...((((.(.....).)))).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((..((.........))..)))))....))))))(.((((((((.((......((((..(((....))).))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........(.((.((......)).))).....))....))...(((((........)))))]]((((..(((((((...((((....)))...(.[[((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((......)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(..(((.....((((....)))).....))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.((....(.(.............(......................)...)..)...)).)))))))....((((.....((((..(((((......)))))..........]]..((((...))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))....))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).....((((((.(((.......((.(........(((......))).....))).......((((((...(((((((..(((......)))..))))))).))))))................))).))))))..(((((((..(.......)..))..(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Crystal structure of the Candida albicans 80S ribosome in complex with Hygromycin B; 25S 8cqw 3 121 3.05 RF00001 0003735 0005840 5476 gguugcggccauaucuagcagaaagcaccguuccccguucgaucaaccguaguuaagcugcuaagagcaauaccgaguaguguagugggagaccauacgcgaaacuauugugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<<............>>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of the Candida albicans 80S ribosome in complex with Hygromycin B; 5S 8cqw 4 157 3.05 RF00002 URS0000082EA4_5476 0003735 0005840 5476 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaauaugaauugcagauauucgugaaucaucgaaucuuugaacgcacauugcgcccucugguauuccggagggcaugccuguuugagcgucguu .........................................<<<<<<.((.....>>>.....<.<<<<.....))............>>.>>..>...>>>....<<.....>><<<<<<<<<....>>>>>>>>>.................... .........................................((((((.[[.....))).....(.((((.....]]............)).))..)...)))....((.....))(((((((((....))))))))).................... Crystal structure of the Candida albicans 80S ribosome in complex with Hygromycin B; 5.8S 8cqw B 1741 3.05 RF01960,RF02542,RF01959,RF00177 0003735 0005840 5476 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguacccuacuuggauaaccgugguaauucuagagcuaauacaugcuuaaaaucccgacuguuuggaagggauguauuuauuagauaaaaaaucaaugccuucgggcucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaaucccgacacggggagguagugacaauaaauaacgauacagggcccuuuugggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaaaagcguauauuaaaguuguugcaguuaaaaagcucguaguugaaccuugggcuuggcuggccgggcguacuggacccagccgagccuuuccuucuggguagccgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggccuuugcucgaauauauuagcauggaauaauagaauaggacguuaugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucggggguaucaguauucaguugucagaggugaaauucuuggauuuacugaagacuaacuacugcgaaagcauuuaccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgguuguuguucuuuuauugacgcaaucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauagugcugcuagcauuugcugguauagucacuucuuagagggacuaucgauuucaagucgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgaguauaagccuuggccgagaggucugggaaaucuugugaaacuccgucgugcuggggauagagcauuguaauuguugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuacuaccgauugaauggcuuagugaggccuccggauugguuuauucuggaaccgagaagcuggucaaacuuggucauuuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucau ...<<<<<.{.[[[[>>>>><<<<.<<<<<<...<.<...<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<..<<..<<....<<<............<<.....<..<<.......>>..>......>>........<<<<<..<<....>>..>>>>><...<<<<<<.......((((((.<<<....>>>..............>>>>>>.....>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>....>.>.....<<<<<<<<.<<<<....>>>>.>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>>.........<<<[[.....<.<<...<<<.<<....<<<<<<<<<<...................>>>>>>>>>>.....<<<<...........>>>>....<<<<<.<<.......<<...<.......>..<<<....>>>....>>......>>.>>..>>>.........<<<..<<<<<<<<......))))))...>>>>>>>>>>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<..<<........>>.>>>>>>>>..>>>...<<..]]>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..]]]].}<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<......<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<.....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<.<<<<<<<....>>>>>>>....>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>.....>>.>>>.....>>>>>>>.......>>>>>...>>.>>>>.>>>.....<<<<<<<......<<......<<<.<<<<....>>>>.>>>....>>.......>>>>>>>......<....<<<<<<..........>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<..<...<<<<<..........>>>>>...>..>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>....... ....(((..[.[[[..))).((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((............((.....(..(((.....)))..)......))........(((((..((....))..)))))(.(.(((((........[[.[[..(((....))).....(......)..))))).)...).(..(((..((((..).))).))).)...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(((((((.(((((....))))).)))).)))......(.(.(...........))..).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....(((((.((((...................)))).))))).....((((...........))))....(((((.((.(.....((..((.......)).(((....)))....))..)...)).))..))).........(((..(((((.((.......]]..]]..)).)))))))).....))....((..((.((...((((...(..((((((.....((........))........))))))..)........((....))...))))..)).))...))...)))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((..(..........).))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.........(.(((........))).).......)))))...((.(((...(..((((.....(((.(((((....)))..(.((......)))...)).)))....(((((.((...(((..((((.(.(.(((....))).).)....))))..)))..))..(.((((((.....))))))....)..))))).....)).))......).))))).....).)))))...)).)))).))).(...(((((((......((......(((.((((....)))).)))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..((((..(...(((..............)))...)..))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>...... Crystal structure of the Candida albicans 80S ribosome in complex with Hygromycin B; 18S 8cqw AS 3227 3.05 RF02540,RF02541,RF02543 0003735 0005840 5476 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.......................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..<<<...........<<.<<<<<<...>>>>>>.>>.............<<<<<...<<<<<<<<<<<<.<<<<<<<.....<<<<......>>>>.(.......<<<......)>>>....>>>>>>>....>>>>>>>>....>>>>..>>>>>........<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<<<<<.....<<<<...<<<<......>>>>...>>>>..<<<<<<<.<<<<<<<<.<<<<<<<....<<.<<<<<<<......<<<<<<......>>>>>>.......>>>>>>.>.>>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<..<<<<<.....>>>>>..>>>...<<....>>.......<<<<<..<<<<....>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<.......>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<..<<.........>>..>>>>>....>>>>>>..<<<<<<<<.<<......<<<<..<<<....>>>.>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<<<<<....>>>>>>......>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.....{{<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..[[[..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<...............>>>>><<.<<<<<<<<<<<...........>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<..<<<<<<<<<<<<...<<.................<......>....................>>.>>.>>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>..........}}..<<<<...>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))......<<<<<<<..<<<<.))))))>>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>....<<<<<<<<..<<<<.<.<<<<<.................>>>>>.><<<<<...<<<<....<<<<<<<<<<]]].>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.....<<<<<<.<<<.<.....<<..........<<<....>>>......>>.......<<<<<<...<<<<<<<..<<<......>>>..>>>>>>>.>>>>>>..............>.>>>.>>>>>>..<<<<<<<.............>>....<<<<<<<<<.<<<....<<<<.<..<<<<<......>>>>>..>>>>>...>>>....>>>>.>>>>>..>>>>>.. .......................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........(((((...((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))).)..))))))))....))))..)))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((((((..(..((((...((((.()...))))...))))).((((((((((((((((.(((((((........((((((......((((.(......).)))).......))))))......))))).))))))))))........(((....)))....))))))))....)))))))))))).<((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..((((....))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((....((.(((((((.....(((....(((..(.((((....((((.......))))..)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{..((((.(((...((.........))...))).....(...((......)).).))))....)))))))))))))..........]]].)....))))))))))...)))))))(((((..((.........))..)))))....))))))(.((((((((.((......((((..(((....))).))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........(.((.((......)).))).....))....))...(((((........)))))]]((((..(((.(((...((((....)))...(.[[((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....)))...))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((...........)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(..(((.....((((....)))).....))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.((((......................(......).......................)).)).)))))))....((((.....((((..(((((......)))))..........]]..((((...))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((.(((((....{..)))).)))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).....((((((.(((.......((.(........(((....))).....))).......((((((...(((((((..(((......)))..))))))).))))))................))).))))))..(((((((..(.......)..))..(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Crystal structure of the Candida albicans 80S ribosome in complex with Hygromycin B; 25S 8cqw AT 121 3.05 RF00001 0003735 0005840 5476 gguugcggccauaucuagcagaaagcaccguuccccguucgaucaaccguaguuaagcugcuaagagcaauaccgaguaguguagugggagaccauacgcgaaacuauugugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<<............>>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of the Candida albicans 80S ribosome in complex with Hygromycin B; 5S 8cqw AU 157 3.05 RF00002 URS0000082EA4_5476 0003735 0005840 5476 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaauaugaauugcagauauucgugaaucaucgaaucuuugaacgcacauugcgcccucugguauuccggagggcaugccuguuugagcgucguu .........................................<<<<<<.((.....>>>.....<.<<<<.....))............>>.>>..>...>>>....<<.....>><<<<<<<<<....>>>>>>>>>.................... .........................................((((((.[[.....))).....(.((((.....]]............)).))..)...)))....((.....))(((((((((....))))))))).................... Crystal structure of the Candida albicans 80S ribosome in complex with Hygromycin B; 5.8S 8cqw CM 1765 3.05 RF01960,RF02542,RF01959,RF00177 URS000059AE3B_5476 0003735 0005840 5476 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguaccuuacuacuuggauaaccgugguaauucuagagcuaauacaugcuuaaaaucccgacuguuuggaagggauguauuuauuagauaaaaaaucaaugccuucgggcucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaaucccgacacggggagguagugacaauaaauaacgauacagggcccuuuugggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaaaagcguauauuaaaguuguugcaguuaaaaagcucguaguugaaccuugggcuuggcuggccgguccauaugcguacuggacccagccgagccuuuccuucuggguagccauuuauggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggccuuugcucgaauauauuagcauggaauaauagaauaggacguuaugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucggggguaucaguauucaguugucagaggugaaauucuuggauuuacugaagacuaacuacugcgaaagcauuuaccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgguuguuguucuuuuauugacgcaaucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauagugcugcuagcauuugcugguauagucacuucuuagagggacuaucgauuucaagucgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgaguauaagccuuggccgagaggucugggaaaucuugugaaacuccgucgugcuggggauagagcauuguaauuguugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuacuaccgauugaauggcuuagugaggccuccggauugguuuaggaaauucuggaaccgagaagcuggucaaacuuggucauuuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucau ...<<<<<.{.((((>>>>><<<<.<<<<<<...<.<...<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<..<<..<<....<<<...............<<.....<..<<.......>>..>......>>........<<<<<..<<....>>..>>>>><...<<<<<<.........((((.<<<....>>>..............>>>>>>.....>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>....>.>.....<<<<<<<<<<<<.....>>.>>>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>>.........<<<[[.....<.<<...<<<.<<....<<<<<<<<<<.........<..>.............>>>>>>>>>>.....<<<<....................>>>>....<<<<<.<<.......<<...<.......>..<<<....>>>....>>......>>.>>..>>>.........<<<..<<<<<<<<<.....))))....>>>>>>>>>>>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<..<<........>>.>>>>>>>>..>>>...<<..]]>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..)))).}<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<.....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<.<<<<<<<....>>>>>>>....>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>.....>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<......<<<.<<<<....>>>>.>>>....>>.......>>>>>>>......<....<<<<<<..........>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<..<...<<<<<<<.<.<...>.>.>>>>>>>...>..>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>....... ....(((..[.[[[..))).((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((...............((.....(..(((.....)))..)......)).........((((..((....))..)))).(.(.(((((.........[.[[[.(((....))).....(......)..))))).)...).(..(((..((((..).))).))).)...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(((((((.(((.......).)).)))).)))....(.(.(.(...........))..)......)..((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....(((((.((((....(..(..().)....).......)))).)))))......((((..................)))).....(((((.((.(.....((..((.......)).(((....)))....))..)...)).))..))).........(((..(((((.((......]]]...]..)).)))))))).....))....((..((..(...((((...(..((((((.....((........))........))))))..)........((....))...))))..)..))...))...)))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((..(..........).))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.........(.(((........))).).......)))))...((.(((...(..((((.....(((.(((((....)))..(.((......)))...)).)))....(((((.((...(((..((((((.(((((....))))).)..).))))..)))..))..(.((((((.....))))))....)..))))).....)).))......).))))).....).)))))...)).)))).))).(...(((((((......((......(((.((((....)))).)))....)).......)))))))......(....((((((..........))))))....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..((((..(...((((((.............))))))...)..))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>...... Crystal structure of the Candida albicans 80S ribosome in complex with Hygromycin B; 18S 8cre 1 3216 3.0 RF02540,RF02541,RF02543 0003735 0005840 5476 ugaccucaaaucagguaggacuacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaacagggauugccucaguagcggcgagugaagcggcaaaagcucaaauuugaaaucuggcgucuuuggcguccgaguuguaauuugaagaagguaucuuugggcccggcucuugucuauguuccuuggaacaggacgucacagagggugagaaucccgugcgaugagaugacccgggucuguguaaaguuccuucgacgagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcuugagaucagacuugguauuuugcaugcgguuuaccgggccagcaucgguuuggagcggcaggauaauggcggaggaauguggcacggcuucugcuguguguuauagccucugacgauacugccagccuagaccgaggacugcgguuuaccuaggauguuggcauaaugaucuuaagucgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccguacgcguaaugaaagugaacgaaggugggggcccauuagggugcaccaucgaccgauccugauguguucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagaagucuugggguugaaaugaccuuaacuuauucucaaacuuuaaauauguaagaaguccuuguugcuuaauugaacguggacaauugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacgugaaguuaaagugccggaaugcacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcgugcuacuuauacuucaccgugauugcuguuuugacgcuuucacgaguaggcaggcguggaggucagugacgaagccuuugcuguaaagcugggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccaugucaacagcaguuggacauggguuagucgauccuaagagauggggaagcuccguuucaacgugcuugauuuuucaggccaaccaucgaaagggaauccgguuaaaauuccggaacuuggauauggauucuucacggcaacguaacugaauguggagacgucggcgugagcccugggaggaguuaucuuuucuucuuaacagcuuaucacccuggaauugguuuauccggagauggggucuuauggcuggaagagcgcgguaauuuugccgcguccggugcgcuuacgacgguccuugaaaauccacaggaaggaauaguuuucaugccaagucguacucauaaccgcagcaggucuccaagguuaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaaggaucgguuuaacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugugauggucagaaagugauguugacacaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaaaagacauggaggguguagaauaagugggagcuucggcgccggugaaauaccacuaccucuauaguuuuuuuacuuauucaaugaagcggagcuggaggucaaacuccacguucuagcauuaagcccucugggcgauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagguguccuaagggggacucauggagaacagaaaucuccaguagaacaaaaggguaaaaguccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaucgcaauaguaauugaacuuaguacgagaggaaccguucauucagauaauugguuuuugcggcugucugaucaggcaacgccgcgaagcuaccaucugcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcgaugauuuuugcccugcacauuuuagauggauacgaauaagacuuuuuagucgcuggaccauagcaggcuggcaacggugcgcuuagcggaaaggcuuugugcgcuugccggcggauagcaaugucaacaugcgcggggauaaauccuuugcauacgacuuagauguacaacggaguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagcucuuguugucugauuugu .......................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[...........<<.<<<<<<...>>>>>>.>>.............<<<<<...<<<<<<<<<<<<.<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>....>>>>>>>>....>>>>..>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<<<<<.....<<<<..<<<<..>>>>..>>>>..<<<<<<<.<<<<<<<<.<<<<<<<....<<.<<<<<<<......<<<<<<......>>>>>>.......>>>>>>.>.>>.>>>>>.>>>>>>>>>>........<<<..>>>.....>>>>>>>....>>>>>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<..<<<<<.....>>>>>..>>>...<<....>>.......<<<<<..<<<<....>>>>...>>>>>.<<<<<<<<<..<<....>>>..>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.........>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<..<<.........>>..>>>>>....>>>>>><.<<<<<<<<.<<......<<<<..<<<....>>>.>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<<<<<....>>>>>>......>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<...............>>>>><<.<<<<<<<<<<<......>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<<...<.<<............................................>>.>...>>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>..............<<<<...>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<.................>>>>>..<<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.....<<<<<<.<<<.<.....<<..........<<<......>>>......>>.......<<<<<<...<<<<<<<..<<<......>>>..>>>>>>>.>>>>>>..............>.>>>.>>>>>>..<<<<<<<.............>>....<<<<<<<<<.<<<....<<<<.<..<<<<<......>>>>>..>>>>>...>>>....>>>>.>>>>>..>>>>>.. .......................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........(((((...((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))).)..))))))))....))))..)))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((((((..(..((((..((((()))))..))))).((((((((((((((((.(((((((........((((((......((((((......)))))).......))))))......))))).))))))))))........(((..)))....))))))))....)))))))))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..((((....))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((........)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((....((.(((((((.....(((....(((..(.((((...((((.(.....).)))).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((..((.........))..)))))....))))))(.((((((((.((......((((..(((....))).))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........(.((.((......)).))).....))....))...(((((........)))))]]((((..(((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((......)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(..(((.....((((....)))).....))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..((((((((((....(.(.............(...(......)...............)...)..)...))))))))))....((((.....((((..(((((......)))))...........>..((((...))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))....))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).....((((((.(((.......((.(........(((......))).....))).......((((((...(((((((..(((......)))..))))))).))))))................))).))))))..(((((((..(.......)..))..(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Crystal structure of the Candida albicans 80S ribosome in complex with geneticin G418; 25S 8cre 3 121 3.0 RF00001 0003735 0005840 5476 gguugcggccauaucuagcagaaagcaccguuccccguucgaucaaccguaguuaagcugcuaagagcaauaccgaguaguguagugggagaccauacgcgaaacuauugugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of the Candida albicans 80S ribosome in complex with geneticin G418; 5S 8cre 4 157 3.0 RF00002 URS0000082EA4_5476 0003735 0005840 5476 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaauaugaauugcagauauucgugaaucaucgaaucuuugaacgcacauugcgcccucugguauuccggagggcaugccuguuugagcgucguu .........................................<<<<<<.((.....>>>.....<.<<<<.....))............>>.>>..>...>>>....<<.....>><<<<<<<<<....>>>>>>>>>.................... .........................................((((((.[[.....))).....(.((((.....]]............)).))..)...)))....((.....))(((((((((....))))))))).................... Crystal structure of the Candida albicans 80S ribosome in complex with geneticin G418; 5.8S 8cre B 1761 3.0 RF01960,RF02542,RF01959,RF00177 URS000059AE3B_5476 0003735 0005840 5476 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguaccuuacuacuuggauaaccgugguaauucuagagcuaauacaugcuuaaaaucccgacuguuuggaagggauguauuuauuagauaaaaaaucaaugccuucgggcucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaaucccgacacggggagguagugacaauaaauaacgauacagggcccuuuugggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaaaagcguauauuaaaguuguugcaguuaaaaagcucguaguugaaccuugggcuuggcuggccgguccgcguacuggacccagccgagccuuuccuucuggguagccauuuauggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggccuuugcucgaauauauuagcauggaauaauagaauaggacguuaugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucggggguaucaguauucaguugucagaggugaaauucuuggauuuacugaagacuaacuacugcgaaagcauuuaccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgguuguuguucuuuuauugacgcaaucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauagugcugcuagcauuugcugguauagucacuucuuagagggacuaucgauuucaagucgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgaguauaagccuuggccgagaggucugggaaaucuugugaaacuccgucgugcuggggauagagcauuguaauuguugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuacuaccgauugaauggcuuagugaggccuccggauugguuuaggaaauucuggaaccgagaagcuggucaaacuuggucauuuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucau ...<<<<<.{.((((>>>>><<<<.<<<<<<...<.<...<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<..<<..<<....<<<...............<<.....<..<<.......>>..>......>>........<<<<<..<<....>>..>>>>><...<<<<<<.......{.((((.<<<....>>>..............>>>>>>.....>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>....>.>.....<<<<<<<<.<<<<....>>>>.>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>>.........<<<[[.....<.<<...<<<.<<....<<<<<<<<<<......................>>>>>>>>>>.....<<<<....................>>>>....<<<<<.<<.......<<...<.......>..<<<....>>>....>>......>>.>>..>>>.........<<<..<<<<<<<<......)))).}...>>>>>>>>>>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<..<<........>>.>>>>>>>>..>>>...<<..]]>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..)))).}<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<.....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<.<<<<<<<....>>>>>>>....>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>.....>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<......<<<.<<<<....>>>>.>>>....>>.......>>>>>>>......<....<<<<<<..........>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<..<...<<<<<<.............>>>>>>...>..>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>....... ....(((..[.[[[..))).((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((...............((.....(..(((.....)))..)......))........(((((..((....))..)))))(.(.(((((........[[.[[..(((....))).....(......)..))))).)...).(..(((..((((..).))).))).)...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(((((((.(((((....))))).)))).)))......(.(.(...........))..).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....(((((.((((.......(...)..........)))).))))).....((((....................))))....(((((.((.(.....((..((.......)).(((....)))....))..)...)).))..))).........(((..(((((.((.......]]..]]..)).)))))))).....))....((..((.((...((((...(..((((((.....((........))........))))))..)........((....))...))))..)).))...))...)))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((..(..........).))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.........(.(((........))).).......)))))...((.(((...(..((((.....(((.(((((....)))..(.((......)))...)).)))....(((((.((...(((..((((.(.(((((....))))).)....))))..)))..))..(.((((((.....))))))....)..))))).....)).))......).))))).....).)))))...)).)))).))).(...(((((((......((......(((.((((....)))).)))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..((((..(...(((((...............)))))...)..))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>...... Crystal structure of the Candida albicans 80S ribosome in complex with geneticin G418; 18S 8cre AS 3229 3.0 RF02540,RF02541,RF02543 URS0000C2FD9C_5476 0003735 0005840 5476 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.......................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..<<<...........<<.<<<<<<...>>>>>>.>>.............<<<<<...<<<<<<<<<<<<.<<<<<<<.....<<<<......>>>>.(.......<<<......)>>>....>>>>>>>....>>>>>>>>....>>>>..>>>>>........<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<<<<<.....<<<<...<<<<......>>>>...>>>>..<<<<<<<.<<<<<<<<.<<<<<<<....<<.<<<<<<<......<<<<<<......>>>>>>.......>>>>>>.>.>>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<..<<<<<.....>>>>>..>>>...<<....>>.......<<<<<..<<<<....>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<.......>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<..<<.........>>..>>>>>....>>>>>>..<<<<<<<<.<<......<<<<..<<<....>>>.>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<<<<<....>>>>>>......>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>......{<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..[[[..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<...............>>>>><<.<<<<<<<<<<<...........>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<..<<<<<<<<<<<<...<<.................<......>....................>>.>>.>>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>..........}...<<<<...>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))......<<<<<<<..<<<<.))))))>>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>....<<<<<<<<..<<<<.<.<<<<<.................>>>>>.><<<<<...<<<<....<<<<<<<<<<]]].>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.....<<<<<<.<<<.<.....<<..........<<<<....>>>>......>>.......<<<<<<...<<<<<<<..<<<......>>>..>>>>>>>.>>>>>>..............>.>>>.>>>>>>..<<<<<<<.............>>....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. .......................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........(((((...((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))).)..))))))))....))))..)))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((((((..(..((((...((((.()...))))...))))).((((((((((((((((.(((((((........((((((......((((.(......).)))).......))))))......))))).))))))))))........(((....)))....))))))))....)))))))))))).<((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..((((....))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((....((.(((((((.....(((....(((..(.((((....((((.......))))..)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{..((((.(((...((.........))...))).....(...((......)).).))))....)))))))))))))..........]]].)....))))))))))...)))))))(((((..((.........))..)))))....))))))(.((((((((.((......((((..(((....))).))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........(.((.((......)).))).....))....))...(((((........)))))]]((((..(((.(((...((((....)))...(.[[((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....)))...))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((...........)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(..(((.....((((....)))).....))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.((((......................(......).......................)).)).)))))))....((((.....((((..(((((......)))))..........]]..((((...))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).....((((((.(((.......((.(........((((....)))).....))).......((((((...(((((((..(((......)))..))))))).))))))................))).))))))..(((((((..(.......)..))..(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Crystal structure of the Candida albicans 80S ribosome in complex with geneticin G418; 25S 8cre AT 121 3.0 RF00001 0003735 0005840 5476 gguugcggccauaucuagcagaaagcaccguuccccguucgaucaaccguaguuaagcugcuaagagcaauaccgaguaguguagugggagaccauacgcgaaacuauugugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<<............>>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of the Candida albicans 80S ribosome in complex with geneticin G418; 5S 8cre AU 158 3.0 RF00002 0003735 0005840 5476 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaauaugaauugcagauauucgugaaucaucgaaucuuugaacgcacauugcgcccucugguauuccggagggcaugccuguuugagcgucguuu .........................................<<<<<<.((.....>>>.....<.<<<<.....))............>>.>>..>...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............)).))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of the Candida albicans 80S ribosome in complex with geneticin G418; 5.8S 8cre CM 1765 3.0 RF01960,RF02542,RF01959,RF00177 URS000059AE3B_5476 0003735 0005840 5476 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguaccuuacuacuuggauaaccgugguaauucuagagcuaauacaugcuuaaaaucccgacuguuuggaagggauguauuuauuagauaaaaaaucaaugccuucgggcucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaaucccgacacggggagguagugacaauaaauaacgauacagggcccuuuugggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaaaagcguauauuaaaguuguugcaguuaaaaagcucguaguugaaccuugggcuuggcuggccgguccauaugcguacuggacccagccgagccuuuccuucuggguagccauuuauggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggccuuugcucgaauauauuagcauggaauaauagaauaggacguuaugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucggggguaucaguauucaguugucagaggugaaauucuuggauuuacugaagacuaacuacugcgaaagcauuuaccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgguuguuguucuuuuauugacgcaaucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauagugcugcuagcauuugcugguauagucacuucuuagagggacuaucgauuucaagucgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgaguauaagccuuggccgagaggucugggaaaucuugugaaacuccgucgugcuggggauagagcauuguaauuguugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuacuaccgauugaauggcuuagugaggccuccggauugguuuaggaaauucuggaaccgagaagcuggucaaacuuggucauuuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucau ...<<<<<.{.((((>>>>><<<<.<<<<<<...<.<...<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<..<<..<<....<<<...............<<.....<..<<.......>>..>......>>........<<<<<..<<....>>..>>>>><...<<<<<<.......{.((((.<<<....>>>..............>>>>>>.....>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>....>.>.....<<<<<<<<<<<<.....>>.>>>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>>.........<<<[[.....<.<<...<<<.<<....<<<<<<<<<<.........<..>.............>>>>>>>>>>.....<<<<....................>>>>....<<<<<.<<.......<<...<.......>..<<<....>>>....>>......>>.>>..>>>.........<<<..<<<<<<<<<.....)))).}..>>>>>>>>>>>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<..<<........>>.>>>>>>>>..>>>...<<..]]>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..)))).}<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<.....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<.<<<<<<<....>>>>>>>....>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>.....>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<......<<<.<<<<....>>>>.>>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<..<...<<<<<<<.<.<...>.>.>>>>>>>...>..>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>....... ....(((..[.[[[..))).((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((...............((.....(..(((.....)))..)......)).........((((..((....))..)))).(.(.(((((.........[.[[[.(((....))).....(......)..))))).)...).(..(((..((((..).))).))).)...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(((((((.(((.......).)).)))).)))....(.(.(.(...........))..)......)..((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....(((((.((((....(..(..().)....).......)))).)))))......((((..................)))).....(((((.((.(.....((..((.......)).(((....)))....))..)...)).))..))).........(((..(((((.((......]]]...]..)).)))))))).....))....((..((..(...((((...(..((((((.....((........))........))))))..)........((....))...))))..)..))...))...)))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((..(..........).))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.........(.(((........))).).......)))))...((.(((...(..((((.....(((.(((((....)))..(.((......)))...)).)))....(((((.((...(((..((((((.(((((....))))).)..).))))..)))..))..(.((((((.....))))))....)..))))).....)).))......).))))).....).)))))...)).)))).))).(...(((((((......((......(((.((((....)))).)))....)).......)))))))......(....((((((..........))))))....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..((((..(...((((((.............))))))...)..))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>...... Crystal structure of the Candida albicans 80S ribosome in complex with geneticin G418; 18S 8crx A 1505 2.78 RF00177,RF01959,RF02542,RF01960 URS0000A1FB0E_1747 36864821 0003735 0005840 1747 cauuggagaguuugauccuggcucaggacgaacgcuggcggcgugcuuaacacaugcaagucgaacggaaaggcccuuggggugcucgaguggcgaacgggugaguaacacgugaguaaccugcccuugacuuugggauaacuucaggaaacuggggcuaauaccggauaggagcuccugcugcaugguggggguuggaaaguuucggcgguuggggauggacucgcggcuuaucagcuuguuggugggguaguggcuuaccaaggcuuugacggguagccggccugagagggugaccggccacauugggacugagauacggcccagacuccuacgggaggcagcaguggggaauauugcacaaugggcggaagccugaugcagcaacgccgcgugcgggaugacggccuucggguuguaaaccgcuuucgccugugacgaagcgugagugacgguaauggguaaagaagcaccggcuaacuacgugccagcagccncggugauacguagggugcgagcguuguccggauuuauugggcguaaagggcucguaggugguugaucgcgucggaaguguaaucuuggggcuuaacccugagcgugcuuucgauacggguugacuugaggaagguaggggagaauggaauuccugguggagcgguggaaugcgcagauaucaggaggaacaccaguggcgaaggcgguucucugggccuuuccugacgcugaggagcgaaagcguggggagcgaacaggcuuagauacccugguaguccacgcuguaaacgguggguacuaggugugggguccauuccacggguuccgugccguagcuaacgcuuuaaguaccccgccuggggaguacggccgcaaggcuaaaacucaaaggaauugacggggccccgcacaagcggcggagcaugcggauuaauucgaunnaacgcguagaaccuuaccuggguuugacauggaucgggagugcucagagaugggugugccucuuggucgguucacagguggugcauggcugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuuguucacuguugccagcacguuaugguggggacucaguggagaccgccggggucaacucggaggaagguggggaugacgucaagucaucaugccccuuauguccagggcuucacgcaugcuacaauggcugguacagagaguggcgagccugugagggugagcgaaucucggaaagccggucucaguucggauuggggucugcaacucgaccucaugaagucggagucgcuaguaaucgcagaucagcaacgcugcggugaauacguucccggggcuuguacacacngncngunaagucaugaaaguugguaacacccgaagccgguggccuaaccguugugggggagccgucgaaggugggacuggugauuaggacuaagucgnaacaagguagccguaccngnnggugcggcuggauca .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<..<<.<<<..>>>...>>>..>>>>>......<<........<<<<<<<..<<...<<<<<<<<<<<<.....<<<<<<....>>>>>>......>>>>.....<<<<<<<<<<....>>>>>>>>>>.....<<....>>>>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<<<<<<<......<<....>>.......>>>>>>...>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<.....<<<<<<<.....>>>>>>>...>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<<..<<<......>>>.....>>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>...<<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>>.........<<<<<<..<<<<<<<<<<<<.<...>.>>>>>>>>>>>>..<<<..))>>>....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<.<....<<<<<<....>>>>>>...........>.>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<......>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<..<<<<....<.<<<<..<<<..<......>.>>>.>>>>.>...>>>>..>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(.(((..)))...)))..)))))......(((.......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....((((((((((....)))))))))).....(......).)))))))..))))))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((((((((...(...(....)...)....))))))...)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((.....(((((((.....)))))))...))))))))..)))))))))..((((.((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))))..)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.(...).))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((.((.(...(((((((....))))))).(.....).).).).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((......)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((..((((....(.((((..(((..(......).))).)))).)...))))..))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Cutibacterium acnes 70S ribosome with mRNA, P-site tRNA and Sarecycline bound; RNA (1537-MER) 8crx a 2903 2.78 RF02541 URS000268139D_1747 36864821 0003735 0005840 1747 caaaguuguguagugcgaucgguggaugccuuggcaccaagagccgaugaaggacguugugaccugcgauaagcccuggggaguuggugagcgagcugugauccggggguguccgaauggggaaaccuggaauguccggaguaguguccgguggcccugcccugaauguauaggggugugggugguaacgcggggaagugaaacaucuuaguacccguaggaagagaaaacaagugugauuccgugaguaguggcgagcgaaagcggaggaggcuaaaccgugugugugucagguguugcaugugcgggguugugggggccuugugguucugcugccgcaggauuggccagugagaaauguugcgugaaggugaagcgucugggaaggcguaccggagugggugagaguccuguaacuguaagcguggcacuggugugggguugccccgaguagcgugggacucguggaauuucgcgugaaucuggcgggaccacccgucaagccuaaauacuccuuggugaccgauaguggaugaguaccgugagggaagggugaaaaguaccccgggaggggagugaaagaguuccugaaaccggucgcaugcaagccgucagagccuguguggugauggcgugccuuuugaagaaugagccugcgaguuagugaugcguggcgagguuaacccguggugggggagucguagcgaaagcgaguccgauaagggcgugagucgcguguucuagacccgaagcggugugaucuauccauggccaggaugaagcgucgguaagacgucguggagguccgaacccacuucaguugaaaauggaggggaugaguuguggauaggggugaaaggccaaucaaacaccgugauagcugguucuccccgaaaugcauuuaggugcagcguugcgugguucuuguuggagguagagcacuggauggucuagggggcuuaucggcuuaccgaaaucagccaaacuccgaaugcuggcaaguguagcguggcagugagacggcgggugauaagcuucgucgucgagagggaaacagcccagaucaucagcuaaggccccuaaguggugacucagugggaaaggauguggaguugcguagacaaccaggagguuggcuuggaagcagccauccuugaaagagugcguaauagcucacuggucaagugauuccgcgccgauaauguagcggggcuuaaguuauccgccgaagcuguggcaaccugugugguuggguaggggagcgucgugucaguggugaagcugccgggugacugugugguggaguugaugcgagugagaaugcaggcaugaguagcgugugacgggugggaaucccguccgccgauuauccaaggguuccagggucaaguuugucugcccugggugagucggguccuaaggcgaggccgacaggcguagucgauggguaaccaguugauauucugguaccggcuugucaccgcaagcugcggagggacgcagugagguagcucauccccggugaugguuguccggggcuaaguguguggacugucugguagguaaauccgcugggcgugaagguugaggcaugauggggagcccaugguugugggugagugagugauccuguacugucgagaaaagcuucgugagcgagguggcggguccgcccguacccuaaaccgacacugguggauagguagaguauaccgaggcgaucgagugaaucguggugaaggaacucggcaaaaugcccccguaacuuugggauaagggggaccugagcugucgugcacccgugcggugugguggcggugaggggcgcagaguccagggggaaacgacuguuuaccaaaaacacagguccgugcgaagucguaagacgauguauacggacugacuccuncccggugcuggaagguuaaggggaacugugaguguaugcguagcggugaacuuaagccccaguaaacggcggugguaacnauaaccauccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggaguaacgauuucccuacugucuccaccaugaacucggugaaauugcauuacgaguaaagaugcucguuacgcgcagcaggacggaaagaccccgggaccuuuacuauaguuugguauuggugauugggacgguuuucugauuguucugguuaucucacuguggaccgugauccgguucaaggacagugccugauggguaguuugacugnggcggucgccuccuaaaggguaacggaggcgcccaaagguucccucagccugguugguaaucagguggugaguguaagugcacaagggggcuugacugugagacugacaggucgagcagggacgaaagucgggacuagugaucugacgguggcuuguggaugcgccgucacucaacggauaaaagguaccccgngganaacaggcugaucuugcccgagcgcucauagcgacggcaugguuuggcancucgnugucggcucgucgcauccuggggcuggagucggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucccuauccgcugcgcgcggaggaaucuugagaagggcugucuuuaguacgagaggaccgagacggacugaccucuggugugccaguuguucugccaagagcauggcugguuggcuacgucggguugugauaaccgcugaaagcaucuaagcgggaagcacgcuucaagauaaggguucccacaggaguguuccugguaagguccccgagagaugaucggguugauaggccagacguggacgcaucguaagguguggagcugacugguacuaauagaccgaggacuuuca ..<<<.......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<...<<)))....>>.......>>>>>>>...>>>....<<<....>>>.......<<<<<......>>>>>..<<<<.<<<<<.........>>>>>..>>>>>>...<<<<<<.....<<....>>......>>>>>.>.........<<<..>>>..<<<<<<.....<<.....>>....>>>>>>..<<<....<<<<......................>>>>......<<<<<<<<<......<<<<....>>>>..................<<...<....<<<....<<<<......>>>>.((......<<<.....))>>>...>>>.......>...>>......>>>>>..>>>>.....<<<<<<<<.........>>>>>>>>.......<<<<..<<<<>>>>...>>>......]].>>>>>>>.]]...............<<....>>....]].........<<<<....>>>>..................>>>>>>>>>>>.......<<<<..<<<.....>>>..>>>>...<.<........>.>.<<<<<<....<<<.<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<.<<......>>.>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<....<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>>>....>>>>>>>.>>..<<<<<<<<<........>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<..<<...<<<.........>>>...>>.........<<......>>....>>>>....>>>>>>>>>.>>...........)))......>>>>>>.>>>...>>>>>>><<<<<.....>>>>>....>>>>>>..<<<<<<<<<.......<<<<<<<<....>>>.>>>>>....>>>>>>>>>........>>>>>>.......<<....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<.<<..<..<....<<<<<<<<<....<<<<..<<<..<<<<<.<<<<<<...((((...>>>>>><<..<<<<...<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>...>>>>...>>....<<.........>>.....>>>>>...>>>...>>>>.........>>>>>>.>>>...>..>..>>.>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<<...<<<<<<<<.<<...............<<<<<...............>>>>>.<<<..<<<<<<<..................>>>>>>>..>>>.............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<..<<<...<<<<<..<<....>>...>>>>>...>>>..>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>>>>>>>>.......((..<<<<<......))>>>>>..<<<<<<<<.(((.[[......<<<<<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<..........>>>>>>>>>>>>>...<<.<<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<.<<<<<..<<.......>>>..>>>>.>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<..<<<<<<<<<<<<))))>>>>>>..>>>>>>..>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<....>>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>...>>>>......>>>.. ..((........((((((((((.....(((..(((((((((((((......((((((....[[[.))).....((((((......]]]..............))))))...)))....(((....))).(.....(((((......))))))..(((.(((((.........)))))..))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((........................)))....(.(((((((.(.......(((....)))...................((........(((...(((((......)))))[[(...).(((.....]])))...)))...........))......).)))..))))]....((((((((..[......))))))))....).(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((..(((.....)))..)))).<.(.(........).).((((((....(((.((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((.((......)).)))...)[)))...(((.(((((.......A))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((..((((((((((.....(((...(((.((((...((.(((......)))..))...)))).)))..)).).....)))))))).).)))))))).))..(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{..((.(.(.(..(((.........)))...)).....(....(......)..).).))....)))))))))).))...........]]].)....))))))))))...)))))))(((((.....)))))....))))))(.((((((.(((......((((((((....))).)))))...))).))))))..).....))))))(......((....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]](((.((..(..(....((.((((((....(((((.(((..(((.(.(((((((...{{{.).))))))((..((((...(((((((((((.((.....))))))))).....))))...))))...))....((.........)).....).)))...)))..)))))(..).....))))))..))...)..)..)).))))))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....))))).(((...(((((......(......)......)))))...))).(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((..((....))...)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....))[[..(((((.....>]])))))..((((((((.(((.((......((((((((((..(((((.(((.(((((.(((((((((.(...(......)...).)))))))))...((.(((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.(.((((...((.......))...)))).)...).)).).)......(.((.((((((..((((.((((......)))).)..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..a.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..((((......))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...)))).......)).. Cutibacterium acnes 70S ribosome with mRNA, P-site tRNA and Sarecycline bound; 23S ribosomal RNA 8crx b 120 2.78 RF00001 URS0000F006E4_1747 36864821 0003735 0005840 1747 uuuccgguggccauaguggaagggaaacacccggucccauuccgaacccggucguuaagccuuccaacgcugaugguacugcacgagggaucgugugggagaguaagacgcugccggaau .<<<<<<<<<<....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<.......<<<<<<<<....>>>>>>>>.......>>..>>>>>>>>>>. .((((((((((....((((((((.....((((((...(.....)...))))..))....)))))).)).((.......((((((((....)))))))).......))..)))))))))). Cutibacterium acnes 70S ribosome with mRNA, P-site tRNA and Sarecycline bound; 5S ribosomal RNA 8crx Y 10 2.78 36864821 562 aaaauguuuu .......... .......... Cutibacterium acnes 70S ribosome with mRNA, P-site tRNA and Sarecycline bound; 32MF mRNA 8crx C 76 2.78 RF00005 URS000041AF00_562 36864821 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Cutibacterium acnes 70S ribosome with mRNA, P-site tRNA and Sarecycline bound; P-site initiator tRNA 8cvj 1A 2871 2.4 RF02541 URS00001698E8_300852 36316410 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<....<<...<<<<<<<<.....<<<........>>>......>>>>>>>>..>>.....>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..<.......(...>...>>>.........<<......>>.).>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<.......<<<<.<<....>>.>>>>....>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<...>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((..(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....((((((((..[......))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...((((((((.(..(((..........))..))..))))))))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((..((.........))...))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((..((((((((.(.........(((((..(((.......((((.((....)).))))....)))............)))))).))))))))..))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..(((...)))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Phe-NH-tRNAphe, peptidyl P-site fMSEAC-NH-tRNAmet, and deacylated E-site tRNAphe at 2.40A resolution; 23S Ribosomal RNA 8cvj 1B 120 2.4 RF00001 URS000080DEE8_300852 36316410 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Phe-NH-tRNAphe, peptidyl P-site fMSEAC-NH-tRNAmet, and deacylated E-site tRNAphe at 2.40A resolution; 5S Ribosomal RNA 8cvj 1a 1500 2.4 RF00177,RF01959,RF02542,RF01960 URS000080DFED_300852 36316410 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<......>>....>>>>>>>.<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((((((....))))))).)))))......(((......((((((((..((...(((((((.(((((....((((........)))).....)))))....((((..((((....))))..))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((.(((....))).)))....(((....)))....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Phe-NH-tRNAphe, peptidyl P-site fMSEAC-NH-tRNAmet, and deacylated E-site tRNAphe at 2.40A resolution; 16S Ribosomal RNA 8cvj 1v 13 2.4 36316410 10665 aaaaauguucuaa ............. ............. Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Phe-NH-tRNAphe, peptidyl P-site fMSEAC-NH-tRNAmet, and deacylated E-site tRNAphe at 2.40A resolution; MF-mRNA 8cvj 1w 74 2.4 RF00005 URS00005AA258_562 36316410 0030533 0006412 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcaccn <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[..)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Phe-NH-tRNAphe, peptidyl P-site fMSEAC-NH-tRNAmet, and deacylated E-site tRNAphe at 2.40A resolution; A-site Aminoacyl-tRNA Phe-NH-tRNAphe 8cvj 1x 77 2.4 RF00005 URS000041AF00_562 36316410 0030533 0006412 562 cgcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaaccn .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Phe-NH-tRNAphe, peptidyl P-site fMSEAC-NH-tRNAmet, and deacylated E-site tRNAphe at 2.40A resolution; P-site Peptidyl-tRNA fMSEAC-NH-tRNAmet RNA-part 8cvj 1y 74 2.4 RF00005 URS00005AA258_562 36316410 0030533 0006412 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((......)))).((((.........)))).....(((((.......)))))))))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Phe-NH-tRNAphe, peptidyl P-site fMSEAC-NH-tRNAmet, and deacylated E-site tRNAphe at 2.40A resolution; E-site Deacylated tRNAphe 8cvj 2A 2800 2.4 RF02541 URS00001698E8_300852 36316410 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu 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(.(......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....(..)....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...((((((((....(...............)....))))))))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((.().)))))))).))..........]]].)....))))))))))...)))))))(((((((..)))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((.((.((((((.(......[..(((((...(.(.....((((((((....))))))))...))...........].)))))).)))))).)).))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))..(...)......(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....).) Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Phe-NH-tRNAphe, peptidyl P-site fMSEAC-NH-tRNAmet, and deacylated E-site tRNAphe at 2.40A resolution; 23S Ribosomal RNA 8cvj 2B 120 2.4 RF00001 URS000080DEE8_300852 36316410 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>>. .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Phe-NH-tRNAphe, peptidyl P-site fMSEAC-NH-tRNAmet, and deacylated E-site tRNAphe at 2.40A resolution; 5S Ribosomal RNA 8cvj 2a 1503 2.4 RF00177,RF01959,RF02542,RF01960 URS000080DFED_300852 36316410 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggau .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<......>>....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>.........<.<<<<<<<........>>>>>>>>.........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((.(....).)))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.(((((((((.......((((((.....)))))).....)))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...((((((......))))))....(.(....).)....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.(.((....)).)).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}... Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Phe-NH-tRNAphe, peptidyl P-site fMSEAC-NH-tRNAmet, and deacylated E-site tRNAphe at 2.40A resolution; 16S Ribosomal RNA 8cvj 2v 13 2.4 36316410 10665 aaaaauguucuaa ............. ............. Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Phe-NH-tRNAphe, peptidyl P-site fMSEAC-NH-tRNAmet, and deacylated E-site tRNAphe at 2.40A resolution; MF-mRNA 8cvj 2w 72 2.4 RF00005 URS00005AA258_562 36316410 0030533 0006412 562 cccgganagcucagggagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcaccn <<<<<<..<<<<.....>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((...[.)))).((((.........)))).....(((((..]....)))))))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Phe-NH-tRNAphe, peptidyl P-site fMSEAC-NH-tRNAmet, and deacylated E-site tRNAphe at 2.40A resolution; A-site Aminoacyl-tRNA Phe-NH-tRNAphe 8cvj 2x 77 2.4 RF00005 URS000041AF00_562 36316410 0030533 0006412 562 cgcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaaccn .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Phe-NH-tRNAphe, peptidyl P-site fMSEAC-NH-tRNAmet, and deacylated E-site tRNAphe at 2.40A resolution; P-site Peptidyl-tRNA fMSEAC-NH-tRNAmet RNA-part 8cvj 2y 73 2.4 RF00005 URS00005AA258_562 36316410 0030533 0006412 562 gcccgganagcucagggagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<.....>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[.)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Phe-NH-tRNAphe, peptidyl P-site fMSEAC-NH-tRNAmet, and deacylated E-site tRNAphe at 2.40A resolution; E-site Deacylated tRNAphe 8cvk 1A 2871 2.5 RF02541 URS00001698E8_300852 36316410 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<....<<<<........>>>..>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..<<.........>>...>>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<.......<<<<<<.<..>.>>>>>>....>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((..(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...((((((((.(..(((..........)..)))..))))))))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((..((.(((.........))..)))......(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((.((.((((((.(.........(((((..(.(.......((((.((....)).))))....).)............)))))).)))))).)).))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..(((...)))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Phe-NH-tRNAphe, peptidyl P-site fMRC-NH-tRNAmet, and deacylated E-site tRNAphe at 2.50A resolution; 23S Ribosomal RNA 8cvk 1B 120 2.5 RF00001 URS000080DEE8_300852 36316410 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>>> (((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).))))))))))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Phe-NH-tRNAphe, peptidyl P-site fMRC-NH-tRNAmet, and deacylated E-site tRNAphe at 2.50A resolution; 5S Ribosomal RNA 8cvk 1a 1500 2.5 RF00177,RF01959,RF02542,RF01960 URS000080DFED_300852 36316410 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<......>>....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((((((....))))))).)))))......(((......((((((((..((...(((((((.(((((....((((.(....).)))).....)))))....((((..((((....))))..))))...(((.....))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((...(((.(((....))).)))....(((....)))....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Phe-NH-tRNAphe, peptidyl P-site fMRC-NH-tRNAmet, and deacylated E-site tRNAphe at 2.50A resolution; 16S Ribosomal RNA 8cvk 1v 13 2.5 36316410 10665 aaaaauguucuaa ............. ............. Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Phe-NH-tRNAphe, peptidyl P-site fMRC-NH-tRNAmet, and deacylated E-site tRNAphe at 2.50A resolution; MF-mRNA 8cvk 1w 74 2.5 RF00005 URS00005AA258_562 36316410 0030533 0006412 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcaccn <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[..)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Phe-NH-tRNAphe, peptidyl P-site fMRC-NH-tRNAmet, and deacylated E-site tRNAphe at 2.50A resolution; A-site Aminoacyl-tRNA Phe-NH-tRNAphe 8cvk 1x 77 2.5 RF00005 URS000041AF00_562 36316410 0030533 0006412 562 cgcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaaccn .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Phe-NH-tRNAphe, peptidyl P-site fMRC-NH-tRNAmet, and deacylated E-site tRNAphe at 2.50A resolution; P-site Peptidyl-tRNA fMRC-NH-tRNAmet RNA-part 8cvk 1y 74 2.5 RF00005 URS00005AA258_562 36316410 0030533 0006412 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((......)))).((((.........)))).....(((((.......)))))))))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Phe-NH-tRNAphe, peptidyl P-site fMRC-NH-tRNAmet, and deacylated E-site tRNAphe at 2.50A resolution; E-site Deacylated tRNAphe 8cvk 2A 2800 2.5 RF02541 URS00001698E8_300852 36316410 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<.....<............>......>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<..>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((..))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((....(...............)....)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((((((()))))))))).))..........]]].)....))))))))))...)))))))(((((((..)))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((.((.((((((.(.........(((((...((......((((((((....))))))))...)).............)))))).)))))).)).))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))..(...)......(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Phe-NH-tRNAphe, peptidyl P-site fMRC-NH-tRNAmet, and deacylated E-site tRNAphe at 2.50A resolution; 23S Ribosomal RNA 8cvk 2B 120 2.5 RF00001 URS000080DEE8_300852 36316410 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Phe-NH-tRNAphe, peptidyl P-site fMRC-NH-tRNAmet, and deacylated E-site tRNAphe at 2.50A resolution; 5S Ribosomal RNA 8cvk 2a 1503 2.5 RF00177,RF01959,RF02542,RF01960 URS000080DFED_300852 36316410 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggau .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>....<<......>>...>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((.(....).)))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...((((((......))))))....(.(....).)....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.(.((....)).)).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}... Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Phe-NH-tRNAphe, peptidyl P-site fMRC-NH-tRNAmet, and deacylated E-site tRNAphe at 2.50A resolution; 16S Ribosomal RNA 8cvk 2v 13 2.5 36316410 10665 aaaaauguucuaa ............. ............. Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Phe-NH-tRNAphe, peptidyl P-site fMRC-NH-tRNAmet, and deacylated E-site tRNAphe at 2.50A resolution; MF-mRNA 8cvk 2w 72 2.5 RF00005 URS00005AA258_562 36316410 0030533 0006412 562 cccgganagcucagggagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcaccn <<<<<<..<<<<.....>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((...[.)))).((((.........)))).....(((((..]....)))))))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Phe-NH-tRNAphe, peptidyl P-site fMRC-NH-tRNAmet, and deacylated E-site tRNAphe at 2.50A resolution; A-site Aminoacyl-tRNA Phe-NH-tRNAphe 8cvk 2x 77 2.5 RF00005 URS000041AF00_562 36316410 0030533 0006412 562 cgcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaaccn .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Phe-NH-tRNAphe, peptidyl P-site fMRC-NH-tRNAmet, and deacylated E-site tRNAphe at 2.50A resolution; P-site Peptidyl-tRNA fMRC-NH-tRNAmet RNA-part 8cvk 2y 73 2.5 RF00005 URS00005AA258_562 36316410 0030533 0006412 562 gcccgganagcucagggagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<.....>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[.)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Phe-NH-tRNAphe, peptidyl P-site fMRC-NH-tRNAmet, and deacylated E-site tRNAphe at 2.50A resolution; E-site Deacylated tRNAphe 8cvl 1A 2871 2.3 RF02541 URS00001698E8_300852 36316410 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<....<<<<........>>>..>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..<<<.....(.>>>...>>>.........<<......>>.).>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<.......<<<<<<<....>>>>>>>....>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<...>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((..(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((.(..(((..........)..)))..)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((..((.........))...))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((.(((.(.((((((.(.........(((((..(((.......((((.((....)).))))....)))............)))))).)))))).).))).)))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..((.....))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Phe-NH-tRNAphe, peptidyl P-site fMTHSMRC-NH-tRNAmet, and deacylated E-site tRNAphe at 2.30A resolution; 23S Ribosomal RNA 8cvl 1B 120 2.3 RF00001 URS000080DEE8_300852 36316410 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Phe-NH-tRNAphe, peptidyl P-site fMTHSMRC-NH-tRNAmet, and deacylated E-site tRNAphe at 2.30A resolution; 5S Ribosomal RNA 8cvl 1a 1500 2.3 RF00177,RF01959,RF02542,RF01960 URS000080DFED_300852 36316410 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<......>>....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((..)))))))).)))))......(((......((((((((..((...(((((((.(((((....(((((......))))).....)))))....((((..((((....))))..))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((((((....)))))))....(((....)))....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Phe-NH-tRNAphe, peptidyl P-site fMTHSMRC-NH-tRNAmet, and deacylated E-site tRNAphe at 2.30A resolution; 16S Ribosomal RNA 8cvl 1v 13 2.3 36316410 10665 aaaaauguucuaa ............. ............. Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Phe-NH-tRNAphe, peptidyl P-site fMTHSMRC-NH-tRNAmet, and deacylated E-site tRNAphe at 2.30A resolution; MF-mRNA 8cvl 1w 74 2.3 RF00005 URS00005AA258_562 36316410 0030533 0006412 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcaccn <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[..)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Phe-NH-tRNAphe, peptidyl P-site fMTHSMRC-NH-tRNAmet, and deacylated E-site tRNAphe at 2.30A resolution; A-site Aminoacyl-tRNA Phe-NH-tRNAphe 8cvl 1x 77 2.3 RF00005 URS000041AF00_562 36316410 0030533 0006412 562 cgcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaaccn .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Phe-NH-tRNAphe, peptidyl P-site fMTHSMRC-NH-tRNAmet, and deacylated E-site tRNAphe at 2.30A resolution; P-site Peptidyl-tRNA fMTHSMRC-NH-tRNAmet RNA-part 8cvl 1y 74 2.3 RF00005 URS00005AA258_562 36316410 0030533 0006412 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((......)))).((((.........)))).....(((((.......)))))))))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Phe-NH-tRNAphe, peptidyl P-site fMTHSMRC-NH-tRNAmet, and deacylated E-site tRNAphe at 2.30A resolution; E-site Deacylated tRNAphe 8cvl 2A 2800 2.3 RF02541 URS00001698E8_300852 36316410 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu 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(((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....(..)....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((....(...............)....)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((((((()))))))))).))..........]]].)....))))))))))...)))))))(((((((..)))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((.((.((((((.(......[..(((((...(.......((((((((....))))))))....)...........].)))))).)))))).)).))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))..(...)......(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Phe-NH-tRNAphe, peptidyl P-site fMTHSMRC-NH-tRNAmet, and deacylated E-site tRNAphe at 2.30A resolution; 23S Ribosomal RNA 8cvl 2B 120 2.3 RF00001 URS000080DEE8_300852 36316410 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>>. .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Phe-NH-tRNAphe, peptidyl P-site fMTHSMRC-NH-tRNAmet, and deacylated E-site tRNAphe at 2.30A resolution; 5S Ribosomal RNA 8cvl 2a 1503 2.3 RF00177,RF01959,RF02542,RF01960 URS000080DFED_300852 36316410 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggau .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<......>>....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((........)))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((.((......)).)))....(.(....).)....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.(.((....)).)).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}... Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Phe-NH-tRNAphe, peptidyl P-site fMTHSMRC-NH-tRNAmet, and deacylated E-site tRNAphe at 2.30A resolution; 16S Ribosomal RNA 8cvl 2v 13 2.3 36316410 10665 aaaaauguucuaa ............. ............. Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Phe-NH-tRNAphe, peptidyl P-site fMTHSMRC-NH-tRNAmet, and deacylated E-site tRNAphe at 2.30A resolution; MF-mRNA 8cvl 2w 72 2.3 RF00005 URS00005AA258_562 36316410 0030533 0006412 562 cccgganagcucagggagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcaccn <<<<<<..<<<<.....>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((...[.)))).((((.........)))).....(((((..]....)))))))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Phe-NH-tRNAphe, peptidyl P-site fMTHSMRC-NH-tRNAmet, and deacylated E-site tRNAphe at 2.30A resolution; A-site Aminoacyl-tRNA Phe-NH-tRNAphe 8cvl 2x 77 2.3 RF00005 URS000041AF00_562 36316410 0030533 0006412 562 cgcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaaccn .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Phe-NH-tRNAphe, peptidyl P-site fMTHSMRC-NH-tRNAmet, and deacylated E-site tRNAphe at 2.30A resolution; P-site Peptidyl-tRNA fMTHSMRC-NH-tRNAmet RNA-part 8cvl 2y 73 2.3 RF00005 URS00005AA258_562 36316410 0030533 0006412 562 gcccgganagcucagggagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<.....>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[.)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Phe-NH-tRNAphe, peptidyl P-site fMTHSMRC-NH-tRNAmet, and deacylated E-site tRNAphe at 2.30A resolution; E-site Deacylated tRNAphe 8cvm a 2903 2.66 RF02541 URS000268139D_1747 36864821 0003735 0005840 1747 caaaguuguguagugcgaucgguggaugccuuggcaccaagagccgaugaaggacguugugaccugcgauaagcccuggggaguuggugagcgagcugugauccggggguguccgaauggggaaaccuggaauguccggaguaguguccgguggcccugcccugaauguauaggggugugggugguaacgcggggaagugaaacaucuuaguacccguaggaagagaaaacaagugugauuccgugaguaguggcgagcgaaagcggaggaggcuaaaccgugugugugucagguguugcaugugcgggguugugggggccuugugguucugcugccgcaggauuggccagugagaaauguugcgugaaggugaagcgucugggaaggcguaccggagugggugagaguccuguaacuguaagcguggcacuggugugggguugccccgaguagcgugggacucguggaauuucgcgugaaucuggcgggaccacccgucaagccuaaauacuccuuggugaccgauaguggaugaguaccgugagggaagggugaaaaguaccccgggaggggagugaaagaguuccugaaaccggucgcaugcaagccgucagagccuguguggugauggcgugccuuuugaagaaugagccugcgaguuagugaugcguggcgagguuaacccguggugggggagucguagcgaaagcgaguccgauaagggcgugagucgcguguucuagacccgaagcggugugaucuauccauggccaggaugaagcgucgguaagacgucguggagguccgaacccacuucaguugaaaauggaggggaugaguuguggauaggggugaaaggccaaucaaacaccgugauagcugguucuccccgaaaugcauuuaggugcagcguugcgugguucuuguuggagguagagcacuggauggucuagggggcuuaucggcuuaccgaaaucagccaaacuccgaaugcuggcaaguguagcguggcagugagacggcgggugauaagcuucgucgucgagagggaaacagcccagaucaucagcuaaggccccuaaguggugacucagugggaaaggauguggaguugcguagacaaccaggagguuggcuuggaagcagccauccuugaaagagugcguaauagcucacuggucaagugauuccgcgccgauaauguagcggggcuuaaguuauccgccgaagcuguggcaaccugugugguuggguaggggagcgucgugucaguggugaagcugccgggugacugugugguggaguugaugcgagugagaaugcaggcaugaguagcgugugacgggugggaaucccguccgccgauuauccaaggguuccagggucaaguuugucugcccugggugagucggguccuaaggcgaggccgacaggcguagucgauggguaaccaguugauauucugguaccggcuugucaccgcaagcugcggagggacgcagugagguagcucauccccggugaugguuguccggggcuaaguguguggacugucugguagguaaauccgcugggcgugaagguugaggcaugauggggagcccaugguugugggugagugagugauccuguacugucgagaaaagcuucgugagcgagguggcggguccgcccguacccuaaaccgacacugguggauagguagaguauaccgaggcgaucgagugaaucguggugaaggaacucggcaaaaugcccccguaacuuugggauaagggggaccugagcugucgugcacccgugcggugugguggcggugaggggcgcagaguccagggggaaacgacuguuuaccaaaaacacagguccgugcgaagucguaagacgauguauacggacugacuccuncccggugcuggaagguuaaggggaacugugaguguaugcguagcggugaacuuaagccccaguaaacggcggugguaacnauaaccauccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggaguaacgauuucccuacugucuccaccaugaacucggugaaauugcauuacgaguaaagaugcucguuacgcgcagcaggacggaaagaccccgggaccuuuacuauaguuugguauuggugauugggacgguuuucugauuguucugguuaucucacuguggaccgugauccgguucaaggacagugccugauggguaguuugacugnggcggucgccuccuaaaggguaacggaggcgcccaaagguucccucagccugguugguaaucagguggugaguguaagugcacaagggggcuugacugugagacugacaggucgagcagggacgaaagucgggacuagugaucugacgguggcuuguggaugcgccgucacucaacggauaaaagguaccccgngganaacaggcugaucuugcccgagcgcucauagcgacggcaugguuuggcancucgnugucggcucgucgcauccuggggcuggagucggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucccuauccgcugcgcgcggaggaaucuugagaagggcugucuuuaguacgagaggaccgagacggacugaccucuggugugccaguuguucugccaagagcauggcugguuggcuacgucggguugugauaaccgcugaaagcaucuaagcgggaagcacgcuucaagauaaggguucccacaggaguguuccugguaagguccccgagagaugaucggguugauaggccagacguggacgcaucguaagguguggagcugacugguacuaauagaccgaggacuuuca 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..((........((((((((((.....(((..(((((((((((((......((((((....[[[.))).....((((((......]]]..............))))))...)))....(((....))).(.....(((((......))))))..(((.(((((.........)))))..))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((........................)))....(.(((((((.(.......(((....)))...................((........(((...(((((......)))))[[(...).(((.....]])))...)))...........))......).)))..))))]....((((((((..[......))))))))....).(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((..(((.....)))..)))).<.(.(........).).((((((....(((.((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((.((......)).)))...)[)))...(((.(((((.......A))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((..((((((((((.....(((...(((.((((...((.(((......)))..))...)))).)))..)).).....)))))))).).)))))))).))..(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{..((.(.(.(..(((.........)))...)).....(....(......)..).).))....)))))))))).))...........]]].)....))))))))))...)))))))(((((.....)))))....))))))(.((((((.(((......((((((((....))).)))))...))).))))))..).....))))))(......((....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]](((.((..(..(....((.((((((....(((((.(((..(((.(.(((((((...{{{.).))))))((..((((...(((((((((((.((.....))))))))).....))))...))))...))....((.........)).....).)))...)))..)))))(..).....))))))..))...)..)..)).))))))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....))))).(((...(((((......(......)......)))))...))).(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((..((....))...)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....))[[..(((((.....>]])))))..((((((((.(((.((......((((((((((..(((((.(((.(((((.(((((((((.(...(......)...).)))))))))...((.(((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.(.((((...((.......))...)))).)...).)).).)......(.((.((((((..((((..(((......)))..)..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..a.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..((((......))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...)))).......)).. Cutibacterium acnes 50S ribosomal subunit with P-site tRNA and Sarecycline bound in the local refined map; 23S ribosomal RNA 8cvm b 120 2.66 RF00001 URS0000F006E4_1747 36864821 0003735 0005840 1747 uuuccgguggccauaguggaagggaaacacccggucccauuccgaacccggucguuaagccuuccaacgcugaugguacugcacgagggaucgugugggagaguaagacgcugccggaau .<<<<<<<<<<....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<.......<<<<<<<<....>>>>>>>>.......>>..>>>>>>>>>>. .((((((((((....((((((((.....((((((...(.....)...))))..))....)))))).)).((.......((((((((....)))))))).......))..)))))))))). Cutibacterium acnes 50S ribosomal subunit with P-site tRNA and Sarecycline bound in the local refined map; 5S ribosomal RNA 8cvm C 76 2.66 RF00005 URS000041AF00_562 36864821 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Cutibacterium acnes 50S ribosomal subunit with P-site tRNA and Sarecycline bound in the local refined map; Initiator fMet RNA 8cwo A 1034 2.84 RF00177,RF01959,RF02542,RF01960 URS0000A1FB0E_1747 36864821 0003735 0005840 1747 cauuggagaguuugauccuggcucaggacgaacgcuggcggcgugcuuaacacaugcaagucgaacggaaaggcccuuggggugcucgaguggcgaacgggugaguaacacgugaguaaccugcccuugacuuugggauaacuucaggaaacuggggcuaauaccggauaggagcuccugcugcaugguggggguuggaaaguuucggcgguuggggauggacucgcggcuuaucagcuuguuggugggguaguggcuuaccaaggcuuugacggguagccggccugagagggugaccggccacauugggacugagauacggcccagacuccuacgggaggcagcaguggggaauauugcacaaugggcggaagccugaugcagcaacgccgcgugcgggaugacggccuucggguuguaaaccgcuuucgccugugacgaagcgugagugacgguaauggguaaagaagcaccggcuaacuacgugccagcagccncggugauacguagggugcgagcguuguccggauuuauugggcguaaagggcucguaggugguugaucgcgucggaaguguaaucuuggggcuuaacccugagcgugcuuucgauacggguugacuugaggaagguaggggagaauggaauuccugguggagcgguggaaugcgcagauaucaggaggaacaccaguggcgaaggcgguucucugggccuuuccugacgcugaggagcgaaagcguggggagcgaacaggcuuagauacccugguaguccacgcuguaaacgguggguacuaggugugggguccauuccacggguuccgugccguagcuaacgcuuuaaguaccccgccuggggaguacggccgcaaggcuaaaacucaaaggaauuacacacngncngunaagucaugaaaguugguaacacccgaagccgguggccuaaccguugugggggagccgucgaaggugggacuggugauuaggacuaagucgnaacaagguagccguaccngnnggugcggcuggauca .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<..<<.<<<..>>>...>>>..>>>>>......<<........<<<<<<<..<<...<<<<<<<<<<<<.....<<<<<<....>>>>>>......>>>>.....<<<<<<<<<<....>>>>>>>>>>.....<<....>>>>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<<<<<<<......<<....>>.......>>>>>>...>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<.....<<<<<<<.....>>>>>>>...>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<<..<<<......>>>.....>>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>...<<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>>.........<<<<<<..<<<<<<<<<<<<.<...>.>>>>>>>>>>>>..<<<..))>>>....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]........<..<<.<.<<<<.<<<..<<<<<<..<<<<....<.<<<<..<<<..<......>.>>>.>>>>.>...>>>>..>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(.(((..)))...)))..)))))......(((.......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....((((((((((....)))))))))).....(......).)))))))..))))))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((((((((...(...(....)...)....))))))...)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((.....(((((((.....)))))))...))))))))..)))))))))..((((.((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))))..)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.(...).))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](..)..(.(..((.(.((((.(((..((((((..((((....(.((((..(((..(......).))).)))).)...))))..))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Cutibacterium acnes 30S ribosomal subunit with Sarecycline bound, body domain only in the local refined map; 16S ribosomal RNA 8cwo Y 10 2.84 36864821 562 aaaauguuuu .......... .......... Cutibacterium acnes 30S ribosomal subunit with Sarecycline bound, body domain only in the local refined map; mRNA 8d1v J 34 2.82 URS0002617747_45657 36190192 45657 uugaugucacggaacacguucuuugaaccaagcu .................................. .................................. Cryo-EM structure of guide RNA and target RNA bound Cas7-11; CRISPR RNA (34-MER) 8d1v N 18 2.82 URS0002617751_45657 36190192 45657 agcuugguucaaagaacg .................. .................. Cryo-EM structure of guide RNA and target RNA bound Cas7-11; SS target RNA (5'-R(P*AP*GP*CP*UP*UP*GP*GP*UP*UP*CP*AP*AP*AP*GP*AP*AP*CP*G)-3') 8d4a B 41 2.74 URS0002681378_32630 36599980 32630 auuucuacuauuguagauuggagcaacaccugaagaaggcu ...<<<<<....>>>>>........................ ...(((((....)))))........................ Cas12a2 quaternary complex; RNA (41-MER) 8d4a C 28 2.74 URS0002681376_32630 36599980 32630 agccuucuucagguguugcuuuagaaag ............................ ............................ Cas12a2 quaternary complex; RNA (28-MER) 8d4b B 41 2.92 URS0002681378_32630 36599980 32630 auuucuacuauuguagauuggagcaacaccugaagaaggcu ...<<<<<....>>>>>........................ ...(((((....)))))........................ Structure of Cas12a2 ternary complex; RNA (41-MER) 8d4b C 28 2.92 URS0002681376_32630 36599980 32630 agccuucuucagguguugcuuuagaaag ............................ ............................ Structure of Cas12a2 ternary complex; RNA (28-MER) 8d8n C 35 3.6 URS0002616B66_237368 36007061 237368 acuuaaugucacgguacccaauuuucugccccgga ................................... ................................... gRAMP non-match PFS target RNA; RNA (35-MER) 8d8n D 21 3.6 URS0002616B7C_237368 36007061 237368 uccggggcagaaaauuggaca ..................... ..................... gRAMP non-match PFS target RNA; RNA (5'-R(P*UP*CP*CP*GP*GP*GP*GP*CP*AP*GP*AP*AP*AP*AP*UP*UP*GP*GP*AP*CP*A)-3') 8d9e C 36 3.76 URS000268141F_237368 36007061 237368 gacuuaaugucacgguacccaauuuucugccccgga .................................... .................................... gRAMP-match PFS target; RNA (36-MER) 8d9e D 21 3.76 URS0002681425_237368 36007061 237368 uccggggcagaaaauugggua ..................... ..................... gRAMP-match PFS target; RNA (5'-R(P*UP*CP*CP*GP*GP*GP*GP*CP*AP*GP*AP*AP*AP*AP*UP*UP*GP*GP*GP*UP*A)-3') 8d9g C 36 2.57 URS000268141F_237368 36007061 237368 gacuuaaugucacgguacccaauuuucugccccgga .................................... .................................... gRAMP-TPR-CHAT Non match PFS target RNA(Craspase); RNA (36-MER) 8d9g D 23 2.57 URS0002681426_237368 36007061 237368 uccggggcagaaaauuggacgau ....................... ....................... gRAMP-TPR-CHAT Non match PFS target RNA(Craspase); RNA (5'-R(P*UP*CP*CP*GP*GP*GP*GP*CP*AP*GP*AP*AP*AP*AP*UP*UP*GP*GP*AP*CP*GP*AP*U)-3') 8d9h C 36 3.6 URS000268141F_237368 36007061 237368 gacuuaaugucacgguacccaauuuucugccccgga .................................... .................................... gRAMP-TPR-CHAT match PFS target RNA(Craspase); RNA (36-MER) 8d9h D 20 3.6 URS0002681421_237368 36007061 237368 uccggggcagaaaauugggu .................... .................... gRAMP-TPR-CHAT match PFS target RNA(Craspase); RNA (5'-R(P*UP*CP*CP*GP*GP*GP*GP*CP*AP*GP*AP*AP*AP*AP*UP*UP*GP*GP*GP*U)-3') 8d9i D 19 3.62 URS0002681428_237368 36007061 237368 uccggggcagaaaauugga ................... ................... gRAMP non-matching PFS-with Mg; RNA (5'-R(P*UP*CP*CP*GP*GP*GP*GP*CP*AP*GP*AP*AP*AP*AP*UP*UP*GP*GP*A)-3') 8d9i C 35 3.62 URS0002616B66_237368 36007061 237368 acuuaaugucacgguacccaauuuucugccccgga ................................... ................................... gRAMP non-matching PFS-with Mg; RNA (35-MER) 8dg7 E 21 3.32 URS0002617752_7227 36182693 7227 gagguaguagguuguauagua ..................... ..................... Structural Basis of MicroRNA Biogenesis by Dicer-1 and Its Partner Protein Loqs-PB - complex III; RNA (22-MER) 8dg7 F 26 3.32 URS0002617760_7227 36182693 7227 cauacuauacaaccuacuaccucucu .......................... .......................... Structural Basis of MicroRNA Biogenesis by Dicer-1 and Its Partner Protein Loqs-PB - complex III; RNA (38-MER) 8dga E 19 3.73 URS0002617752_7227 36182693 7227 gagguaguagguuguauag ................... ................... Structural Basis of MicroRNA Biogenesis by Dicer-1 and Its Partner Protein Loqs-PB - complex IV; RNA (22-MER) 8dga F 22 3.73 URS00023358C1_7227 36182693 7227 cuauacaaccuacuaccucucu ...................... ...................... Structural Basis of MicroRNA Biogenesis by Dicer-1 and Its Partner Protein Loqs-PB - complex IV; RNA (22-MER) 8do6 I 35 3.1 URS00023359D5_176279 37352230 176279 acgagaacacguaugccgaaguauauaaaucauca ................................... ................................... The structure of S. epidermidis Cas10-Csm bound to target RNA; crRNA 8do6 J 26 3.1 URS0002681431_176279 37352230 176279 gaugauuuauauacuucggcauacgu .......................... .......................... The structure of S. epidermidis Cas10-Csm bound to target RNA; Target RNA 8e0f C 32 2.7 URS0002617743_9606 36243986 9606 gcucgcgaugcgngagggcucugauagcuacg ................................ ................................ Human Adenosine Deaminase Acting on dsRNA (ADAR2-RD) bound to dsRNA containing a G-G pair adjacent to the target site; RNA (5-R(*GP*CP*UP*CP*GP*CP*GP*AP*UP*GP*CP*GP*(8AZ)P*GP*AP*GP*GP*GP*CP* UP*CP*UP*GP*AP*UP*AP*GP*CP*UP*AP*CP*G)-3) 8e0f D 32 2.7 URS0002617722_9606 36243986 9606 cguagcuaucagagccccccggcaucgcgagc ................................ ................................ Human Adenosine Deaminase Acting on dsRNA (ADAR2-RD) bound to dsRNA containing a G-G pair adjacent to the target site; RNA(5-R(*CP*GP*UP*AP*GP*CP*UP*AP*UP*CP*AP*GP*AP*GP*CP*CP*CP*CP*CP*CP*GP*GP*CP*AP*UP*CP*GP*CP*GP*AP*GP*C)-3) 8e30 I 2898 1.91 RF02541 URS00004B0F34_562 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccuu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<.<.........>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.......<<.........>>..............<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<......>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<<.<<....>>..>>>>>>..>.....>>>>>>>>..>>>>><<<<<.........>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<.<<...<.............<.<<.................................................>>.>....>...>>.>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>.. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((.(......).))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(............)...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.((((.(......(...........)...............(........)...)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((.(......).))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..((.((....)).))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))((((...........))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((.(...((....................(.............................).....................))...).)))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(.(((((....))).)).)....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))).. E. coli 50S ribosome bound to compound streptogramin A analog 3142; 23S ribosomal RNA 8e30 J 118 1.91 RF00001 URS0000366A67_562 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))). E. coli 50S ribosome bound to compound streptogramin A analog 3142; 5S ribosomal RNA 8e32 I 2898 2.35 RF02541 URS00004B0F34_562 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccuu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<....<<.........>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<.....<<<.......>>>.....>........<<........>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<......>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>.>........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<....<<..>>.....>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.......<<<<<<.<<....>>..>>>>>>.......>>>>>>>>>..>>>>><<<<<.........>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<..<<.............<.................<............>........................>....>>..>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<.)))..>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>.. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))((((((......)))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(............)...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((....(((.....{.((((....(...((.........))...).......(..((........)))..))))...)))....))).))...........]]].)...))))))))))...)))))))(((((((........)))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((.(......).(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((.(((...(..(..........................................(..)......................)..)...))).)))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(.(((((....))).)).)....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))).. E. coli 50S ribosome bound to compound streptogramin analogs SA1 and SB1; 23S ribosomal RNA 8e32 J 118 2.35 RF00001 URS0000366A67_562 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))). E. coli 50S ribosome bound to compound streptogramin analogs SA1 and SB1; 5S ribosomal RNA 8e33 I 2897 2.23 RF02541 URS00004B0F34_562 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccuu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<..........>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<....<<.........>>....>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<......>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>..>.....>>>>>>>>..>>>>><<<<<.........>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<.......>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<.<..................<<<<..............<............>.....................>>>>.........>.>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>.. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))((((((......)))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((.(......).))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((....................)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((..((...................))..........(........)...)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((.(......).))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..((.((....)).))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((.(.(...((............(...............................(..)....................)...))...).).)))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(.(((((....))).)).)....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))).. E. coli 50S ribosome bound to compound streptogramin analog SAB001; 23S ribosomal RNA 8e33 J 118 2.23 RF00001 URS0000366A67_562 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))). E. coli 50S ribosome bound to compound streptogramin analog SAB001; 5S ribosomal RNA 8e35 I 2898 2.27 RF02541 URS00004B0F34_562 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccuu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<.))).....>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>...>>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<.<.........>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<.<<...<........<<<<<.<.....<<<.......>>>.....>........<<<......>>>..>>>>>....>...>>.>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<.<<......>>.>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>.>........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<....<.<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.......<<<<<<.<<....>>..>>>>>>.......>>>>>>>>>..>>>>><<<<<.........>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<.<...<<..............<<<.................................................>>>.....>.>..>.>>>>>>>>...<<<.<<<<<.......>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>............>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<.)))..>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>.. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))((((((......)))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.(((.......((((.((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))).))))....)))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...(((..(......)..)))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((..........))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((..(....(.....{.((((.(......((.........))...............(........)...)))))...)....)..)).))...........]]].)...))))))))))...)))))))((((((..........))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..((.((....)).))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((.(......).(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((.(....(((............(.......(.......................(..)..).................)...)))....).)))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(........).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).).....((.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..))....(.(((((....))).)).)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))).. E. coli 50S ribosome bound to compound SAB002; 23S ribosomal RNA 8e35 J 118 2.27 RF00001 URS0000366A67_562 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<......<<.<<<<<....<<<<<<<.............>>>>..>>>...>>>>>..>>.<<.......<<<<<<<<...>>>>>>>>.......>>....>>>>>>>>. .(((.((.......((.....(....(((((((...(.....)...))))..)))...)......))..(.......((((((((...)))))))).......)......)).))).. E. coli 50S ribosome bound to compound SAB002; 5S ribosomal RNA 8e36 I 2897 2.38 RF02541 URS00004B0F34_562 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccuu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<..........>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<.....<<<.......>>>.....>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<......>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>..>.....>>>>>>>>..>>>>><<<<<.........>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<.......>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<.<..................<<<<.................................................>>>>.........>.>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>.. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))((((((......)))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((.(......).))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(............)...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.((((.(......(...........)...............(........)...)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((.(......).))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..((.((....)).))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))((((...........))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((.(.(...((............(...............................(..)....................)...))...).).)))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(.(((((....))).)).)....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))).. E. coli 50S ribosome bound to compound streptogramin A analog 3146; 23S ribosomal RNA 8e36 J 118 2.38 RF00001 URS0000366A67_562 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))). E. coli 50S ribosome bound to compound streptogramin A analog 3146; 5S ribosomal RNA 8e3l I 2897 2.35 RF02541 URS00004B0F34_562 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccuu .<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>...>>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<....<<.........>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<....<<<.......>>>....>>........<<........>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<.<<......>>.>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<.<<<<<<<.<<.....>>>>>>>>>...>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>.>........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.......<<<<<..<<....>>...>>>>>.......>>>>>>>>>..>>>>><<<<<.........>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<.......>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<..<<.............<.......................................................>....>>..>>>>>>>>>>>...<<<.<<<<<.......>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<.)))..>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>... ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))((((((......)))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((....................)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((....(((.....{.(((((...(...((.........))...)..........((........))..)))))...)))....))).))...........]]].)...))))))))))...)))))))(((((((........)))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))((((...........))))........((.(......).(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((.(((......(..........................................(..)......................)......))).)))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).).....((.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..))....(.(((((....))).)).)....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))).. E. coli 50S ribosome bound to D-linker solithromycin conjugate; 50S ribosomal RNA 8e3l J 118 2.35 RF00001 URS0000366A67_562 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))). E. coli 50S ribosome bound to D-linker solithromycin conjugate; 5S ribosomal RNA 8e3m I 2898 2.25 RF02541 URS00004B0F34_562 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccuu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<.<.........>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<.....<<.........>>.....>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<......>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>..>.....>>>>>>>>..>>>>><<<<<.........>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<.<..................<<<<.................................................>>>>.........>.>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>.. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))((((((......)))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((.(......).))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(............)...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.((((.(......(...........)...............(........)...)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((.(......).))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..((.((....)).))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))((((...........))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((.(..(((............(.......(.......................(..)..).................)...)))..).)))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(.(((((....))).)).)....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))).. E. coli 50S ribosome bound to L-linker solithromycin conjugate; 50S ribosomal RNA 8e3m J 118 2.25 RF00001 URS0000366A67_562 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca ..<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>... (.(((((((.....((((((((....(((((((.............))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))).). E. coli 50S ribosome bound to L-linker solithromycin conjugate; 5S ribosomal RNA 8e3o I 2897 1.99 RF02541 URS00004B0F34_562 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccuu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<.<.........>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<.....<<.........>>.....>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<......>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>..>.....>>>>>>>>..>>>>><<<<<.........>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<.......>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<.<<.................<<<<.................................................>>>>........>>.>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>.. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((.(......).))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(............)...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.((((.(......((.........))...............(........)...)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((.(......).))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))((((...........))))........((.(......).(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((.....(..(..........(.......(.......................(..)..).................).)..).....)))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(.(((((....))).)).)....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))).. E. coli 50S ribosome bound to solithromycin and VM1; 23S ribosomal RNA 8e3o J 118 1.99 RF00001 URS0000366A67_562 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (((((((((.....((.(((((....(((((((...(.....)...))))..)))...)))))..)).((.......((((((((...)))))))).......))...))))))))). E. coli 50S ribosome bound to solithromycin and VM1; 5S ribosomal RNA 8e40 R 22 3.57 URS0002681372_562 36598981 562 uuuuuuuuuuuuuuaaaaaaaa ...................... ...................... Full-length APOBEC3G in complex with HIV-1 Vif, CBF-beta, and fork RNA; RNA 8e40 r 25 3.57 URS0002681377_562 36598981 562 uuuuuuuuaaaaaaaaaaaaaaaaa ......................... ......................... Full-length APOBEC3G in complex with HIV-1 Vif, CBF-beta, and fork RNA; RNA 8e41 I 2898 2.13 RF02541 URS00004B0F34_562 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccuu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<.<.........>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.......<<.........>>..............<<........>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<......>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>..>.....>>>>>>>>..>>>>><<<<<.........>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<.<....<.............<<<<.................................................>>>>....>....>.>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>.. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))((((((......)))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((.(......).))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((....................)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((...................................(........)...)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((.(......).))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..((.((....)).))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))((((...........))))........((.(......).(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((.(..(((....................(.............................).....................)))..).)))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(.(((((....))).)).)....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))).. E. coli 50S ribosome bound to tiamulin and VS1; 50S ribosomal RNA 8e41 J 118 2.13 RF00001 URS0000366A67_562 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))). E. coli 50S ribosome bound to tiamulin and VS1; 5S ribosomal RNA 8e42 I 2898 2.29 RF02541 URS00004B0F34_562 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccuu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<..........>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<...<<........<<<<<.<<....<<<.......>>>....>>........<<<......>>>..>>>>>....>>...>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<......>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<..<<....>>...>>>>>..>....>>>>>>>>>..>>>>><<<<<.........>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<.<<..<<..............<<<.................................................>>>.....>>..>>.>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>.. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))((((((......)))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((.(......).))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(............)...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.((((.(......((.........))...............(........)...)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((..........))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..((.((....)).))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((.(..(.(....................(.............................).....................).)..).)))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(.(((((....))).)).)....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))).. E. coli 50S ribosome bound to tiamulin and azithromycin; 50S ribosomal RNA 8e42 J 118 2.29 RF00001 URS0000366A67_562 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (((((((.(.....((((((((....(((((((.............))))..)))...)))))).)).((.......((((((((...)))))))).......))...).))))))). E. coli 50S ribosome bound to tiamulin and azithromycin; 5S ribosomal RNA 8e43 I 2897 2.09 RF02541 URS00004B0F34_562 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccuu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<.<.........>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<....<<.........>>....>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<......>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>.>........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>..>.....>>>>>>>>..>>>>><<<<<.........>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<.......>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<.<..................<.<<.................................................>>.>.........>.>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>.. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))((((((......)))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((.(......).))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(............)...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((...((.........))...)).)........(........)...)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((.(......).))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))((((...........))))........((.(......).(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((.(.....((............(.......(.......................(..)..).................)...)).....).)))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(.(((((....))).)).)....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))).. E. coli 50S ribosome bound to compound streptogramin A analog 3336; 23S ribosomal RNA 8e43 J 118 2.09 RF00001 URS0000366A67_562 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (((((((((.....((.(((((....(((((((...(.....)...))))..)))...)))))..)).((.......((((((((...)))))))).......))...))))))))). E. coli 50S ribosome bound to compound streptogramin A analog 3336; 5S ribosomal RNA 8e44 I 2898 2.53 RF02541 URS00004B0F34_562 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccuu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<......>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<....<<<.......>>>....>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<.<<......>>.>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>..>.....>>>>>>>>..>>>>><<<<<.........>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<.<...<<.............<.<<.................................................>>.>....>>...>.>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>.. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))((((((......)))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((....................)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.((((.(.((...(...........)...))..........(........)...)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((..........))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..((.((....)).))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((....(((............................................(..)........................)))....)))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).).....((.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..))....(.(((((....))).)).)....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))).. E. coli 50S ribosome bound to antibiotic analog SLC09; 23S ribosomal RNA 8e44 J 118 2.53 RF00001 URS0000366A67_562 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))). E. coli 50S ribosome bound to antibiotic analog SLC09; 5S ribosomal RNA 8e45 I 2897 2.3 RF02541 URS00004B0F34_562 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccuu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<.)))..]..>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<..........>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<......<<<<.......>>>>.............<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<......>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>.>........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.......<<<<<<.<<....>>..>>>>>>.......>>>>>>>>>..>>>>><<<<<.........>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<.......>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<.<...<<............<<<<<.................................................>>>>>...>>...>.>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>.. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...(((..(......)..)))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(............)...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.......((((.((.....((.........))......)........(........)...)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((.(......).))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..(((.(....).)))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))((((...........))))........((.(......).(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((((.((.(..(..............(...............................(..)....................).....)..).)).))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).).....((.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..))....(.(((((....))).)).)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))).. E. coli 50S ribosome bound to antibiotic analog SLC17; 23S ribosomal RNA 8e45 J 118 2.3 RF00001 URS0000366A67_562 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<...<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>...>>>. .(......(.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)......).. E. coli 50S ribosome bound to antibiotic analog SLC17; 5S ribosomal RNA 8e46 I 2897 2.32 RF02541 URS00004B0F34_562 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccuu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<....<<.........>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<...<........<<<<<.<....<<<<.......>>>>.....>.......<<<......>>>..>>>>>....>...>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<.<<......>>.>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<......>>>>...>>>>>>...>>>...>>>.>........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.......<<<<<<.<<....>>..>>>>>>.......>>>>>>>>>..>>>>><<<<...........>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<.......>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<.<....<.............<.<<.................................................>>.>....>....>.>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<.)))..>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>.. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))((((((......)))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...(((..(......)..)))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(............)...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((...(.(...((.........))...)..)........(........).....)))...)))..))))).))...........]]].)...))))))))))...)))))))(((((((........)))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..((..........))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))((((...........))))........((.(......).(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((...(.................(.......(.......................(..)..).................)........)...)))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(.(((((....))).)).)....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))).. E. coli 50S ribosome bound to antibiotic analog SLC21; 23S ribosomal RNA 8e46 J 118 2.32 RF00001 URS0000366A67_562 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<....<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>....>>>. .((.....(.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...).....)).. E. coli 50S ribosome bound to antibiotic analog SLC21; 5S ribosomal RNA 8e47 I 2898 2.32 RF02541 URS00004B0F34_562 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccuu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<.))).....>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>...>>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<.<...<<<.<<<<.....<.........>....>>>>.>>>..>..>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<.<<...<........<<<<<.<<....<<<.......>>>....>>........<<<......>>>..>>>>>....>...>>.>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<.<<......>>.>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>.>........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<....<.<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.......<<<<<<.<<....>>..>>>>>>.......>>>>>>>>>..>>>>><<<<<.........>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<.<...<<.............<<<<.................................................>>>>....>.>..>.>>>>>>>>...<<<.<<<<<.......>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>............>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<.)))..>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>.. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))((((((......)))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.(((.......((((.((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))).))))....)))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...(((..(......)..)))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(............)...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((..(...((.....{.((((.(.((...((.........))...))..........(........)...)))))...))...)..)).))...........]]].)...))))))))))...)))))))(((((((........)))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((.(...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..((.((....)).))...))))))...)))...))))(..).....))))...).....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..(......)...)))))........))))))))..)))))((((...........))))........((.(......).(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((.(.(..(((............(.......(.......................(..)..).................)...)))..).).)))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(........).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).).....((.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..))....(.(((((....))).)).)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))).. E. coli 50S ribosome bound to antibiotic analog SLC26; 23S ribosomal RNA 8e47 J 118 2.32 RF00001 URS0000366A67_562 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<......<.<<<<<<.....<<<<<<.............>>>>..>>....>>>>>>..>.<<........<<<<<<<...>>>>>>>........>>....>>>>>>>>. .(((.((.......((.(...(....(.(((((.............))))..).)...)...)..))..(.......((((((((...)))))))).......)......)).))).. E. coli 50S ribosome bound to antibiotic analog SLC26; 5S ribosomal RNA 8e48 I 2898 2.27 RF02541 URS00004B0F34_562 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccuu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<.))).....>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<.<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>.>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>...>>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<.<.........>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<.....<<.........>>.....>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<.<<......>>.>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<..<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>.>........>>>>...>>....>>>>>>>..>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.......<<<<<<.<<....>>..>>>>>>.......>>>>>>>>>..>>>>><<<<<.........>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<.<...<<.............<<<<.................................................>>>>....>.>..>.>>>>>>>>...<<<.<<<<<.......>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<.)))..>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>.. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))((((((......)))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...(((..(((.......((((.((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))).))))....)))........((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...(((..(......)..)))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(............)...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...(((.[[...(.((((((.....(.....((..(((((..(((.....{.(((((..((...((.........))...))..........(........)...)))))...)))..))))).))...........]]..)...))))))))))...)))))))((((((..........))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]]((.....((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..((.((....)).))...))))))...)))...))))(..).....))))...))....)))).....)).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..(......)...)))))........))))))))..)))))(((((.........)))))........((.(......).(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((.(.(..((.............(.......(.......................(..)..).................)....))..).).)))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(.(((((....))).)).)....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))).. E. coli 50S ribosome bound to antibiotic analog SLC30; 23S ribosomal RNA 8e48 J 118 2.27 RF00001 URS0000366A67_562 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<......<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>....>>>>>>>>. ((((.((.......((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......)).....)).)))). E. coli 50S ribosome bound to antibiotic analog SLC30; 5S ribosomal RNA 8e49 I 2898 2.05 RF02541 URS00004B0F34_562 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccuu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<.<.........>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<.....<<.........>>.....>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<......>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<<.<<....>>..>>>>>>..>....>>>>>>>>>..>>>>><<<<<.........>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<.<....<.............<<<<.................................................>>>>....>....>.>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>.. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))((((((......)))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(.(......)...)...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((...................................(........)...)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((..........))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..((.((....)).))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((.(.(..(.(............(.......(.......................(..)..).................)...).)..).).)))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(.(((((....))).)).)....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))).. E. coli 50S ribosome bound to antibiotic analog SLC31; 23S ribosomal RNA 8e49 J 118 2.05 RF00001 URS0000366A67_562 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))). E. coli 50S ribosome bound to antibiotic analog SLC31; 5S ribosomal RNA 8e4x C 32 2.8 URS0002617743_9606 36243986 9606 gcucgcgaugcgngagggcucugauagcuacg ................................ ................................ Human Adenosine Deaminase Acting on dsRNA (ADAR2-R2D) bound to dsRNA containing a G:3-deaza dA pair adjacent to the target site; RNA (5-R(*GP*CP*UP*CP*GP*CP*GP*AP*UP*GP*CP*GP*(8AZ)P*GP*AP*GP*GP*GP*CP* UP*CP*UP*GP*AP*UP*AP*GP*CP*UP*AP*CP*G)-3) 8e4x D 32 2.8 URS0002617724_9606 36243986 9606 cguagcuaucagagccccccngcaucgcgagc ................................ ................................ Human Adenosine Deaminase Acting on dsRNA (ADAR2-R2D) bound to dsRNA containing a G:3-deaza dA pair adjacent to the target site; RNA(5-R(*CP*GP*UP*AP*GP*CP*UP*AP*UP*CP*AP*GP*AP*GP*CP*CP*CP*CP*CP*CP*(4DU)*GP*CP*AP*UP*CP*GP*CP*GP*AP*GP*C)-3) 8e5t 1 743 4.0 RF02543 URS000061F377_1247190 37037974 0003735 0005840 1247190 guuugaccucaaaucagguaggaguacccgcugaaaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguacggugcccgaguuguaauuuggagagggcaacuuguaaagugccuucgaagagucgaguuguuuugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagacuuugaaaagagaguaaauuguugaaagggaagggcauuugaucagacauggugucacugggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguagguuggggccucgcaagaggugcacaaucgaccgugaguaagagcauagcuguugggaguuccugccgaaguagaguuaaggugccggaauacacgcucaucagaggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggug ..........................<<<<<<....>>>>>.>...<.....<<....>>..<<<<<......<<.....>>.....>>>>>..<<<..<........<<.<<<<<.>>>>>.>>........>....<<<<<<<.<<.....>>>>>>>>>........<<<<<<<...>>>>>>>.....<<<<<<......>>>>>>..>>>....>............<<<<....>>>>.....................<<<<<.<<<<<<..<..<<<<.>>>>.><<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<......>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<<...<<<<<<.<<<<<<..<<<<.<<<<<.....>>>>>.>>>>...<<<<<..<<<<<....>>>>>...>>>>>.<<.....>>....>>>>>>.>>>>>>..<<.<<<<<<...<<<<<<<..<<<<(((.....<<<<<<.....<<.))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>>..<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>>...>>>>>>>. ..........................(((((......)))).).........((....))...((((......((.....)).....))))...((.(.........(((.(((((.))))).))....)........((.((((..((...)).)))).))...)....(((((((...))))))).....((((.(.......)))))...)).................((((....)))).....................(((((.((((((..(.(((((.))))))(((((((((((((((((((((((.......((..(((......((((........)))).......)))..)).....))))).))))))))))........(((....)))....))))))))....)))))).)))))..(((..........)))..((((....((((((.((((((..(((..(((((.....)))))..)))...(((((..(((((....)))))...))))).(((..).))....)))))).))))))..((.((((((...(((((((...((([[[...(.((((((......(.]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))..((((((((.((......((((.((((....))))))))...))))))))))..))....))))... Yeast co-transcriptional Noc1-Noc2 RNP assembly checkpoint intermediate; 25S ribosomal RNA 8e5t 2 138 4.0 RF00002 URS000041658A_1247190 37037974 0003735 0005840 1247190 aaaacuuucaacaacgggguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu ........................................<<((....>>.........<<<<.....))............>.>>>........<<<<<<<<<....>>>>>>>>>..................... ..........................................[[.............(.((((.....]]............).)))..).....(((((((((....)))))))))..................... Yeast co-transcriptional Noc1-Noc2 RNP assembly checkpoint intermediate; 5.8S ribosomal RNA 8e5t 3 87 4.0 URS000013305B_1247190 37037974 1247190 ccuucucaaacauucuguuugguagugagugauacucuuuggaguuaacuugaaauugcuggccuuuaggcgaacaauguucuuaaa ......<<<<<<...>>>>>>.....<<<<...<<<<....>>>>..>>>>..........<<<<..>>>>................ ......(((((.....)))))....(((((...((((....))))..))))..).......((((..))))................ Yeast co-transcriptional Noc1-Noc2 RNP assembly checkpoint intermediate; ITS2 ribosomal RNA 8eey C 38 2.53 URS0002617753_45657 36423276 45657 uugaugucacggaaccuuuguugucuucgacaugggua ...................................... ...................................... Cas7-11 in complex with DR-mismatched target RNA, Csx29 and Csx30; crRNA 8eey D 28 2.53 URS0002617778_32630 36423276 32630 uacccaugucgaagacaacaaaguauuu ............................ ............................ Cas7-11 in complex with DR-mismatched target RNA, Csx29 and Csx30; DR-mismatched target RNA 8eiu A 1519 2.24 RF00177,RF01959,RF02542,RF01960 URS00000ABFE9_562 36660825 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugccggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<........>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<.>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<..>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((.(........).))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((.)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((((())))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))...(......)..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... E. coli 70S ribosome with A-loop mutations U2554C and U2555C; 16S rRNA 8eiu X 12 2.24 36660825 562 aaaaugauguaa ............ ............ E. coli 70S ribosome with A-loop mutations U2554C and U2555C; mRNA 8eiu Y 74 2.24 RF00005 URS00026813B1_562 36660825 0030533 0006412 562 gcgggguggagcagccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacc <<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>.... ((((((..((((.....[..)))).(((((.......))))).....(((((..]....))))))))))).... E. coli 70S ribosome with A-loop mutations U2554C and U2555C; tRNA-fMET 8eiu Z 74 2.24 RF00005 URS00026813B1_562 36660825 0030533 0006412 562 gcgggguggagcagccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacc <<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>.... ((((((..((((.....[..)))).(((((.......))))).....(((((..]....))))))))))).... E. coli 70S ribosome with A-loop mutations U2554C and U2555C; tRNA-fMET 8eiu a 2753 2.24 RF02541 URS0002681390_562 36660825 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagcgucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcgcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcngcccgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<....<.<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>..>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<..>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<..>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<....<....>.....>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.......<<<<<..<<....>>...>>>>>.......>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<..>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......((((.((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))).))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((.((((.....))))..))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(())...)))..))))).))...........]]].)...))))))))))...)))))))((((((((()))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((....((((..)])))....)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((())))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). E. coli 70S ribosome with A-loop mutations U2554C and U2555C; 23S rRNA 8eiu b 119 2.24 RF00001 URS0000049E57_562 36660825 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>> ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))) E. coli 70S ribosome with A-loop mutations U2554C and U2555C; 5S rRNA 8ekb 1A 2871 2.7 RF02541 URS00001698E8_300852 36546783 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<.....<<<........>>>......>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..<<.........>>...>>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>>....<<<..>>>......>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<.......<<<<.<<....>>.>>>>....>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<...>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((...((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((....(((.(......).)..))...)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((..((.........))...))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((.((((((((.(......[..(((((..(((.......(((((((....)))))))....)))..........].)))))).)))))))).)))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..(((...)))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, deacylated P-site tRNAmet, and thermorubin at 2.70A resolution; 23S Ribosomal RNA 8ekb 1B 120 2.7 RF00001 URS000080DEE8_300852 36546783 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> (((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).))))))))))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, deacylated P-site tRNAmet, and thermorubin at 2.70A resolution; 5S Ribosomal RNA 8ekb 1a 1500 2.7 RF00177,RF01959,RF02542,RF01960 URS000080DFED_300852 36546783 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<......>>....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((((((....))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((..((((....))))..))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((...(((.(((....))).)))....(((....)))....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, deacylated P-site tRNAmet, and thermorubin at 2.70A resolution; 16S Ribosomal RNA 8ekb 1x 76 2.7 RF00005 URS000041AF00_562 36546783 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, deacylated P-site tRNAmet, and thermorubin at 2.70A resolution; P-site deacylated tRNAmet 8ekb 2A 2800 2.7 RF02541 URS00001698E8_300852 36546783 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<..........>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<..>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...((((((((.....))))))))....{.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).))))....(((((((((.[.....)))))))))....}.(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((()))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((.....((..........))......)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((((((()))))))))).))..........]]].)....))))))))))...)))))))(((((((())))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((.((.((((((.(.........(((((..((.......((((((((....))))))))....))............)))))).)))))).)).))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(............(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, deacylated P-site tRNAmet, and thermorubin at 2.70A resolution; 23S Ribosomal RNA 8ekb 2B 120 2.7 RF00001 URS000080DEE8_300852 36546783 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>>. .((((((((((....((((((.(....(.(((((...(.....)...))))..).)...).)))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, deacylated P-site tRNAmet, and thermorubin at 2.70A resolution; 5S Ribosomal RNA 8ekb 2a 1503 2.7 RF00177,RF01959,RF02542,RF01960 URS000080DFED_300852 36546783 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggau .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<......>>....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......(.((((.....)))).)....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((((((....))))))).(..(.(....).)..).)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.(.((....)).)).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}... Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, deacylated P-site tRNAmet, and thermorubin at 2.70A resolution; 16S Ribosomal RNA 8ekb 2x 76 2.7 RF00005 URS000041AF00_562 36546783 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, deacylated P-site tRNAmet, and thermorubin at 2.70A resolution; P-site deacylated tRNAmet 8ekc a 1528 2.7 RF00177,RF01959,RF02542,RF01960 URS00000ABFE9_562 36546783 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugccggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<........>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<..>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((((..........)))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(...(((((((((.......)))))))).)...)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((((())))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((.(((....))).))).............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Escherichia coli 70S ribosome bound to thermorubin, deacylated P-site tRNAfMet and aminoacylated A-site Phe-tRNA; 16S Ribosomal RNA 8ekc w 74 2.7 RF00005 URS00005AA258_562 36546783 0030533 0006412 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<......>>>><<<<<<<.....>>>>>>.>...<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[..)))).((((.........)))).....(((((..]....)))))))))))).... Escherichia coli 70S ribosome bound to thermorubin, deacylated P-site tRNAfMet and aminoacylated A-site Phe-tRNA; A-site phenylalanine tRNA 8ekc x 76 2.7 RF00005 URS000041AF00_562 36546783 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Escherichia coli 70S ribosome bound to thermorubin, deacylated P-site tRNAfMet and aminoacylated A-site Phe-tRNA; P-site initiator tRNA 8ekc v 12 2.7 36546783 2681598 aaaauguucuaa ............ ............ Escherichia coli 70S ribosome bound to thermorubin, deacylated P-site tRNAfMet and aminoacylated A-site Phe-tRNA; M-F-Stop mRNA 8ekc A 2845 2.7 RF02541 URS00004B0F34_562 36546783 0003735 0005840 562 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<<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<..>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<..>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<<.<<....>>..>>>>>>..>....>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<<<<<...<<......<<<<.<<<....>>>.>>>>...>>.............>>>>>...>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. 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Escherichia coli 70S ribosome bound to thermorubin, deacylated P-site tRNAfMet and aminoacylated A-site Phe-tRNA; 23S Ribosomal RNA 8ekc B 120 2.7 RF00001 URS00005C6868_562 36546783 0003735 0005840 562 ugccuggcggcaguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Escherichia coli 70S ribosome bound to thermorubin, deacylated P-site tRNAfMet and aminoacylated A-site Phe-tRNA; 5S Ribosomal RNA 8emm a 2753 2.1 RF02541 URS00004B0F34_562 37308707 0003735 0005840 562 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<<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<..>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<..>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<<.<<....>>..>>>>>>..>....>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<..>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((((((.....))))).))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(())...)))..))))).))...........]]].)...))))))))))...)))))))((((((((()))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((())))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Composite 70S ribosome structure for ""Atomistic simulations of the E. coli ribosome provide selection criteria for translationally active substrates; 23S rRNA 8emm b 119 2.1 RF00001 URS0000049E57_562 37308707 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>> ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))) Composite 70S ribosome structure for ""Atomistic simulations of the E. coli ribosome provide selection criteria for translationally active substrates; 5S rRNA 8emm Y 76 2.1 RF00005 URS00002905B5_562 37308707 0030533 0006412 562 gcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaaccn <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Composite 70S ribosome structure for ""Atomistic simulations of the E. coli ribosome provide selection criteria for translationally active substrates; Met-NH-tRNA 8emm Z 76 2.1 RF00005 URS00002905B5_562 37308707 0030533 0006412 562 gcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaaccn <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Composite 70S ribosome structure for ""Atomistic simulations of the E. coli ribosome provide selection criteria for translationally active substrates; Met-NH-tRNA 8emm A 1519 2.1 RF00177,RF01959,RF02542,RF01960 URS00000ABFE9_562 37308707 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugccggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<......>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<.>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<..>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((.(........).))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((.(....).))))......)).).....(((....)))....((((((.)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((((())))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...((.(((....))).))....(......)..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Composite 70S ribosome structure for ""Atomistic simulations of the E. coli ribosome provide selection criteria for translationally active substrates; 16S rRNA 8emm X 15 2.1 37308707 562 aaaaugauguaacua ............... ............... Composite 70S ribosome structure for ""Atomistic simulations of the E. coli ribosome provide selection criteria for translationally active substrates; mRNA 8esq 1 2230 2.8 RF02543 URS000261779B_4896 36423630 0003735 0005840 4896 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Ytm1 associated nascent 60S ribosome State 2; RNA (2231-MER) 8esq 2 150 2.8 RF00002 URS0000249ACE_4896 36423630 0003735 0002181 0005840,0022626 4896 aaaacuuucagcaacggaucucuuggcucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaagaaucaucgaaucuuugaacgcacugcgccuuuggguucuaccaaaggcaugccuguuugagugucauu ..........................................<<<<<<.<<.....>>>.....(.<<<......>>........>>>..)...>>>....<<<.>>><<<<<<<<......>>>>>>>>.................... ..........................................((((((.[[.....))).....(.((((.....]]......).)))..)...)))....((...))((((((((......)))))))).................... Ytm1 associated nascent 60S ribosome State 2; RNA (150-MER) 8esr 1 2143 3.2 RF02543 URS000261779B_4896 36423630 0003735 0005840 4896 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........................<<<<<<........>>>>>.>.........<<....>>..<<<<<......<<.>>.....>>>>>..<<<..<<.......<<.<<<<<<<.......>>>>>>>.>>.......>>....<<<<<.<<<<<..<<<<<..<<<<<<<<<.....<<<<......>>>>.((......<<<.....))>>>......>>>>>>>>>..>>>>>.....>>>>>>>>.>>........<<<<<<..>>>>>>.....<<<<<<.>>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<<<<<.<<<<<<<.<<<<<<<<<<<<<<<.......<<<<<<<<......<...>......>>>>>>>>......>>>>>.>>>>>>>>>>........<<<..>>>.....>>>>>>>....>>>>>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.......>>>>...>>>...<<.>>.......<<<<<..<<<<<..>>>>>...>>>>>.<<.>>....>>>>>>.>>>>>>..<<.<...<<<<<<...<<<<<<<<<<.>>>>>>>>>>..>>>>>>......>.>>..<<<<<<......<<..>>..<<<<<<<<<....<<<.<<<<<<..>>>>>>>>>.>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<.....<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>...>>>>>>><<<<<<<<<.......>>>>>>>>>....>>>>>>..<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.<<<<<<.......>>>>>><<<<.....<<<...<<...<<<<<<.............>>>>>>....((<<<<<<...<<....<<<....>>>...........<<<<<......>>>>>...>>....>>...<<<<<........>>>>>))<<<<..<<<<<<..<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<...((..>>>>>>....<<<<<...<<<<<<....<<<.....>>>....>>>>>>.....>>>>>.....<<<<<<<.>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>......>>>.>>>.>>>>>>>>..>>..>>>.<<<..>>>..>>>>..<<<<.....<<<<<<<.<<.........<....<<..>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<.<.<<<<<.<<<<<<<<<<<<<.<<<<..>>>>..>>>>>>.>>>>>..>>>>>>>.......<<<<<<...<..>...>>>>>>.<<<<...<<<<..<.<<<<<<<......>>>>>>>...>.<<<..>>>.....>>>>.......>>>>.<<<<<<<....>>>>>>>....>.>>>>>.....<<<<<<<<..<<<<.<.<<<<<.................>>>>>.><<<<<...<<<<....<<<<<<<<<<))..>>>>>..>>>>>...>>>>..>>>>>.<<<<....<<<<...........>>>>....>>>>.>>>>....>>>>>>>>....<<.......<<<<..<..>..>>>>....>>........<<<<<....<<<<<<<<<<<<......>>>>>>>>>>>>..>>>>>..........<<<<<.<.............>.....<<<<<<<<<.<<<....<<<..>>>...>>>....>>>>.>>>>>...>>>>>. ........................(((((..........)))).).........((....))...((((......((.)).....))))...((((.........(((.(((((((.......))))))).))....)........(((((.((((((.(((((..(((((((((...({((((......)))))[[(...).(((....}]])))......)))))))))..))))))....)))))))).))...)....((((((())))))).....(((((...)))))..)))..................................((....))............(..((((....))))............).....................((((((((((((.(((((((((((((((((((((((.......(.((((((......(...)......)))))).)......))))).))))))))))........(((..)))....))))))))....)))))))))))).<((((........))))((((((..(.((((((.((((((..(((...(((.........)))...)))...(...).......(((((..(((((..)))))...))))).((.))....)))))).))))))..((.(...((((((...((.(((((((.))))))).))..))))))......).))).((((((....(.((())).)((((((((.....(((.(((((.().))))))))..)))))).))..((((.((.((.....)).)).))))....(((......)))...(((((((...((([[[...(.((((((......(.....(((.((((((((((.....{.(((((.(.(...((.........))...).).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.......)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.((((((.......))))))((((.....((((..((...((((((.............))))))....[[(((.((...((....(((....)))........(..(((((......))))))..))....))...(((((........)))))]](((.(.(((((((((((....)))...(...((((((...((((.(((((((((((((((((....[[...)))))(...(((((...(((((.....(((.....))).....))))).....)))))....)(((((((.))))))))))).).))))))).))))(...)....))))))...)))))).))).)))).)))..)).)))).(((())))..))))..((((.....(((((((.((..(....(......((())).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((.(((((((.(((((((.(((((.((((()))))..)))))..)))))..)))))))........(((((...(())...)))))..(.((.((.(((..(.(((((((......))))))..).).(((..))).....))).)..)...)).)..((((((....))))))....)).))))).....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((]]..)))))..)))))...))))..))))).((((....(((.....}.......)))....)))).))))....))))))))..(.((.......((((...()...))))....))).......((((((...(((((((.((((......)))).))))))).))))))..........(((((.(..(.......)..)...(.(((((((((.(((....(((())))...)))....)))).))))))..))))). Ytm1 associated nascent 60S ribosome (-fkbp39) State 2; RNA (2142-MER) 8esr 2 150 3.2 RF00002 URS0000249ACE_4896 36423630 0003735 0002181 0005840,0022626 4896 aaaacuuucagcaacggaucucuuggcucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaagaaucaucgaaucuuugaacgcacugcgccuuuggguucuaccaaaggcaugccuguuugagugucauu ..........................................<<<<<<.<<.....>>>.....(.<<<......>>........>>>..)...>>>....<<...>><<<<<<<<......>>>>>>>>.................... ..........................................((((((.[[.....))).....(.((((.....]]......).)))..)...)))....((...))((((((((......)))))))).................... Ytm1 associated nascent 60S ribosome (-fkbp39) State 2; RNA (150-MER) 8etc 1 2140 3.1 RF02543 URS000261779B_4896 36423630 0003735 0005840 4896 auuugaccucaaaucagguaggacuacgcgcugaacucaauaagcgcaggaaaagaaaauaaccaugauucccucaguaacggugaagcgggaaaagcucaaauuugaaaucuggcaacauuucuuuuguuguccgaguuguaauuucaagaagcugcuuugaguguagacgaucggucuaaguuccuuggaacaggacgucagagagggugagaaccccgucuuuggucgauuggauaugccauauaaagcgcuuucgaagagucgaguuguuugcagcucuaaauggguggucaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguagagugaucgaaagaugaaaagaacuuugaaaagagaguuaaauaguacgugaaauugcugaaagggaagcauuggaaaucaggucagcaucaguuuucgggggcggaaaaagaauaagggaagguggcuguuuauagcccuuguuguaauacguccacuggggacugaggacugcggcuucgugccaaggaugcugacauaaugguuuucaauggcccgucuacacggaccaaggagucuagcaucuaugcgaguguuugggugaugaaaacccauccgcgaaaugaaagugaaugcaggugggaacgcccuggcgugcaccaucgaccgacccggaaggguuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaggcagaaacucagaucaguuuuauguguaaaaugagaguuucuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacgugagguuaaggugccggaauguacgcucaucagacaccagaaaagguguuaguucaucuagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaugaacuagcccugaaaauggauggcgcuuaagcguacuacccauaccucaccgucuggguuagaagcucagacgaguaggcaggcguggagguuugugacgaagccuugggcgugagccugggucgaacagccucuagugcagaucuugguggaaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccaugugaacagcaguuggacauggguuagucgauccuaagagauagggaagcuccguaugaaaaucgaaagggaauccgguuaauauuccggaaccagaagguggaacacggcaacguaaaugaaguuggagacgucggcgggagcccugggaagaguucucuuuucuuuuuaacaaaccacacccugaaaucgguuuauccggagcuaggguaugguguuuggaagaguucagcgccucaugcugaauccggugcgcucucgacggccuugaaaauccaacggaaguuucacaucuggucguacucauaaccgcagcaggucuccaaggugagccucuaguugauagaacaauguagauaagggaagucggcaaaaugggaaucgauucccacugucccuaucuacuaucuagcgaaaccacagccuggggaacgggccaggcaaaaucagcgggguggcuuguggcagccaagcgcgacguugcuggcucuuccuaucauaccgaagcagaauucgguaagcguuggacccacuaauagggagcuggguuccuacugaugaagugucgucgcaaugguaauucaacuuaguacgagaggaaccguugauucagaucauugguauuugcggcugccugacaaggcaaugccgcggagcuaucaucugccggauaacggcugaacgccucuaagccagaauccgugccagaaagcgacgauuguauaaaaauagaggucucuccuguaucguagaagaugggcgaugguugaugaaacggaaguguuuuauugacuuguccaugaaauuccagaauccauugcauacgacuuuaauguggaacgggguauuguaagcagcugcugagauuaagccuuuguucccaagauuug ..........................<<<<<<..........>>>>>.>.........<<....>>..<<<<<......<<.>>.....>>>>>..<<<..<<.......<<.<<<<<<<.......>>>>>>>.>>.......>>....<<<<<.<<<<<..<<<<<..<<<<<<<<<.....<<<<......>>>>.((......<<<.....))>>>......>>>>>>>>>..>>>>>.....>>>>>>>>.>>........<<<<<<<..>>>>>>>.....<<<<<..>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<<<<<.<<<<<<<.<<<<<<<<<<<<<<<........<<<<<<<......<...>......>>>>>>>.......>>>>>.>>>>>>>>>>........<<<.....>>>.....>>>>>>>....>>>>>>>>>>>>..<<<<....>>>><<<<<<....<<<<<<.<<<<<<..<<<..<<<<<.......>>>>>..>>>...<<....>>........<<<<..<<<<<..>>>>>...>>>>..<<<<<<<<....>>>.>>>.>>....>>>>>>.>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>.>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<<<<<<<<<<...<<<.<<<<<<..>>>>>>>>>>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>...>>>>>>><<<<<<<<<.....>>>>>>>>>....>>>>>><.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>.........>>....>>...<<<<<........>>>>>))<<<<..<<<....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<....(..>>>>>>....<<<<<...<<<<<<....<<<.....>>>....>>>>>>.....>>>>>.....<<<<<<<<.....>>>>>>>>>>>>...>>>>>>>.>>>>........>>>>>>........>>>.>>>>>>>>..>>.....<<......>>>>>>>.<<<<..>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<<>>>>>>...>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<.........<<<<<<...<..>...>>>>>><<<..<<<<<..<.<<<<<<<......>>>>>>>...>.<<<..>>>.....>>>>>>>>......>>.>>>>>.....<<<<<<<<..<<<<.<.<<<<<.................>>>>>.><<<<<...<<<<...<<<<<<<<<<.)....>>>>..>>>>>>..>>>>..>>>>>.<<<<....<<<<...........>>>>....>>>>.>>>>....>>>>>>>>...<<.......<<<<..>>>>....>>........<<<<<....<<<<<<<<<<<<......>>>>>>>>>>>>..>>>>>.........<<<<<.<.............>.....<<<<<<<<<.<<<....<<<..>>>...>>>....>>>>.>>>>>...>>>>>. ..........................(((((............)))).).........((....))...((((......((.)).....))))...((((.........(((.(((((((.......))))))).))....)........(((((.((((((.(((((..(((((((((...({((((......)))))[[(...).(((....}]])))......)))))))))..))))))....)))))))).))...)....(((((((..))))))).....(((((..)))))..)))..................................((....))............(..((((....))))............).....................((((((((((((.(((((((((((((((((((((((.......(.((((((......(...)......)))))).)......))))).))))))))))........(((.....)))....))))))))....))))))))))))..((((....))))((((((..(.((((((.((((((..(((...((((.......))))...)))...((....)).........(((...((((..))))....)))...((((((((....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...).))).))))))))).(.((.......))...)..))))))......).))).((((((......(((.((.....(((.((((((())))))))))..)).))).....((((.((..(.....)..)).))))....(((......)))...(((((((...((([[[...(.(((((.......(...........((.((((((((((.....{.(((((.(.(...(...........)...).).....(...((......)).).)))))...))))))))))))...........]]].).....)))))))))...)))))))(((((((((.....)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...((((((...((.....)).))))))....[[(((.((...((....(((....))).........))....))...(((((........)))))]]((((..(((....(((....)))...(...((((((...((((.((((((((((((((((((....[..))))))(...(((.....(((((.....(((.....))).....))))).......)))....)((((((((.....)))))))))))).).))))))).))))(..)....))))))...)....))).)))).)))..)).....((......)).)))).((((..))))..))))..((((.....(((((((.((..(....(.......(((((())))).).)..))).)))))))..))))))....)).[..(((((......].)))))....(((.(..((..........(((((...(())...))))).(((..(((((..(.(((((((......))))))..).).(.(..).).....))))))))......)).).)))......(((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((]...)))))..)))))...))))..))))).((((....(((.....}.......)))....)))).))))....)))))))..(.((.......(((....)))....))).......((((((....((((((..(((......)))..))))))..)))))).........(((((.(..(.......)..)...(.(((((((((.(((....(((())))...)))....)))).))))))..))))). Fkbp39 associated nascent 60S ribosome State 4; RNA (2151-MER) 8etc 2 147 3.1 RF00002 URS0000249ACE_4896 36423630 0003735 0002181 0005840,0022626 4896 aaaacuuucagcaacggaucucuuggcucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaagaaucaucgaaucuuugaacgcacauugcgccuuugggaccaaaggcaugccuguuugagugucau ..........................................<<<<<<.<<.....>>>.....(.<<<(.....>>......).>>>..)...>>>....<<.....>><<<<<<<<..>>>>>>>>................... ..........................................((((((.[[.....))).....(.((((...(.]].)....).)))..)...)))....((.....))((((((((..))))))))................... Fkbp39 associated nascent 60S ribosome State 4; RNA (147-MER) 8etg 1 2018 3.4 RF02543 URS000261779C_4896 36423630 0003735 0005840 4896 uugaccucaaaucagguaggacuacgcgcugaaaauaagcgcaggaaaagaaaauaaccaugauucccucaguaacgugaagcgggaaaagcucaaauuugaaaucuggcaacauuucuuuuguuguccgaguuguaauuucaagaagcugcuuugaguguagacgaucggucuaaguuccuuggaacaggacgucagagagggugagaaccccgucuuuggucgauuggauaugccauauaaagcgcuuucgaagagucgaguugugcagcucuaaauggguggucaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguagagugaucgaaagaugaaaagaacuuugaaaagagaguuaaauaguacgugaaauugcugaaagggaagcauuggaaaucaggucagcaucaguuuucgggggcggaaaaagaauaagggaagguggcuguuuauagcccuuguuguaauacguccacuggggacugaggacugcggcuucgugccaaggaugcugacauaaugguuuucaauggcccguccacggaccaaggagucuagcaucuaugcgaguguuugggugaugaaaacccauccgcgaaaugaaagugaggugggaacgcccuuguggcgugcaccaucgaccguaagagcauagcuguugggacccgaaagauggugaaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaaacucagaucaguuuuaugaguauguaaaaugagaguuucuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacgugagguuaaggugccggaauguacgcucaucagaagaaaagguguuaguucaucuagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaugaacuagcccugaaaauggauggcgcuuaagcguacuacccauaccucaccgucuggguuaggaagcucagacgaguaggcaggcguggagguuugugacgaagccuugggcgugagccugggucgaacagccucuagugcagaucuugguggaaguagcuucaaaugagaacuuugaagacugaaguggggaaagguuccaugugaacagcaguuggacauggguuagucgauccuaagagauagggaagcuccguaugaaaggcacgauuuuucgugccuaucgagggaauccgguuaauauuccggaaccagaagguggaauacggcaacguaaaugaaguuggagacgucggcgggagcccugggaagaguucucuuuucuuuuuaacaaaccauuacccugacuaggguaugguguuuggaagaguucagcgccucaugcugaauccggugcgcucucgacggccaaaauccaacggaaguuuucacaucuggucguacucuccaaggugaacagccucuaguugauagaacaauguagauaagggaagaaugggcccacugucccuaucuacuaucuagcgaaaccacagccuggggggccaggcaaaaucagcggcuuguggcagccaagcgcgacguugcucggcucuuccuaucauaccgaagcagaauucgguaagcguuggacccacuaauagggaacgugagcuggccuacugaugaagugucgucgcaaugguaauucaacuuaguacgagaggaaccguugauucagaucauugguauuugcggcugccugacaaggcaaugccgcggagcuaucaucugcuggauaacggcugaacgccucuaagccagaauccgugccagaaagcgacgauuuguauaaaaauagagguaggcuacucuccuguaucguagaagaugggcgaugguugaugaaacggaaguguuuuauugacuuguccaugaaauuccagaauccauugcauacgacuuuaauguggaacgggguauuguaagcagcugcugagauuaagccuuuguucccaagauuug ........................<<<<<<.......>>>>>.>.........<<....>>..<<<<<......<..>.....>>>>>..<<<..<<.......<<.<<<<<<<.......>>>>>>>.>>.......>>....<<<<<.<<<<<..<<<<<..<<<<<<<<<.....<<<<......>>>>.((......<<<.....))>>>......>>>>>>>>>..>>>>>.....>>>>>>>>.>>........<<<<<<..>>>>>>.....<<<<<..>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<<<<<.<<<<<<<.<<<<<<<<<<<<<<<........<<<<<<<.................>>>>>>>.......>>>>>.>>>>>>>>>>........<<<.....>>>.....>>>>>>>....>>>>>>>>>>>>..<<<<..>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.......>>>>...>>>...<<....>>..<<<<<..<<<<<.....>>>>>...>>>>>.<<.>>....>>>>>>.>>>>>>..<<.<...<<<<<<...>>>>>>......>.>>..<<<<<<....<..<<....>>..><<<<<<<<<<...<<<.<<<<<<<....>>>>>>>>>>>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<......<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>...>>>>>>><<<<<<<<<......>>>>>>>>>....>>>>>><.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<<<<<<<.......>>>>>><<<<.....<<<...<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<......>>>>>>..>>..>>...<<<<<........>>>>>))<<<<..<<<<...<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<.......>>>>>>....<<<<....<<<<<<<..>>>>>>>.....>>>>.....<<<<<<<<.....>>>>>>>>>>>>...>>>>>>>.>>>>.....>>>>>>......>..>>>.>>>>>>>>..>>.>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.......<<..>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<....>>>>>....<<<<<.<.......<<<<<...<..>...>>>>>.<<<<...<<<<..<.<<<<<<<......>>>>>>>...>.<<<..>>>.....>>>>.......>>>>...>.>>>>>......<<<<<<<..<<<<.<.<<<<<.................>>>>>.><<<<<...<<<<....<<<<<<<<<......>>>>..>>>>>...>>>>..>>>>>.<<<<....<<<<...........>>>>....>>>>.>>>>....>>>>>>>.....<<.......<<<<<.<..>>.>>>>....>>........<<<<<....<<<<<<<<<<<<......>>>>>>>>>>>>..>>>>>.........<<<<<.<.............>.....<<<<<<<<<.<<<....<<<..>>>...>>>....>>>>.>>>>>...>>>>>. ........................(.(((.........)))..).........((....))...((((......(()).....))))...((((.........(((.(((((((.......))))))).))....)........((((..((((((.(((((...(((..(((...({((((......)))))[[(...).(((....}]])))......)))..)))...))))))....))))).)).))...)....(.((((..)))).).....(((((..)))))..)))..................................((....))............(..((((....))))............).....................((((((((((((.((((((((((((((((.((((((.......((((((((......(...)......))))))))......))))).).))))))))........(((.....)))....))))))))....))))))))))))..((((..))))((((((..(.((((((.((((((..(((...(((.........)))...)))...((....))....(((...((((.....))))....)))...((.))....)))))).))))))..((.(...((((((...))))))......).))).((((((.......((....))...(((((.((.....(((.((((..(....)..)))))))..)).))).))..((((.((..(.....)..)).))))....(((......)))...(((((((...((([[[...(.(((((.......(.......((.((((((((((.....{.(((((.(.(...((.........))...).).........((......))...)))))...))))))))))))...........]]].).....)))))))))...)))))))(((((((((......)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((((((((.......))))))((((.....(((...((...((((((.............))))))....[[(((.((...((....(((....)))........((((((......))))))..))..))...(((((........)))))]]((((..(((.(...((....))........((((((...((((.((((((((((((((((((...[...))))))(...(((.....((((((....))))))......)))....)((((((((.....)))))))))))).).))))))).)))).....))))))......)..))).)))).)))..)).))).((((.....))))..))))..((((.....(((((((.((..(....((()))....))).)))))))..))))))....)).[..(((((..].)))))....(((.(.((......(((((...(())...))))).(.((.((.(((..(.(((((((......))))))..).).(.(..).).....))).)..)...)).)..)).).)))......(((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((.]..)))))..)))))...))))..)))))..(((....(((.....}.......)))....)))..))))....)))))))...(.((.......(((....()....)))....))).......((((((...((.(((.(((((......))))).))).)).)))))).........(((((.(..(.......)..)...(.(((((((((.(((....(((())))...)))....)))).))))))..))))). Fkbp39 associated 60S nascent ribosome State 3; RNA (1912-MER) 8etg 2 146 3.4 RF00002 URS0000249ACE_4896 36423630 0003735 0002181 0005840,0022626 4896 aaaacuuucagcaacggaucucuuggcucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaaucaucgaaucuuugaacgcacgcgccuuuggguucuaccaaaggcaugccuguuugagugucauu ..........................................<<<<<<.<<.....>>>.....(.<<<......>>.....>>>..)...>>>....<<..>><<<<<<<<......>>>>>>>>.................... ..........................................((((((.[[.....))).....(.((((.....]]...).)))..)...)))....((..))((((((((......)))))))).................... Fkbp39 associated 60S nascent ribosome State 3; RNA (146-MER) 8eth 1 1303 3.8 RF02543 URS000261779F_4896 36423630 0003735 0005840 4896 uugaccucaaaucagguaggacuacgcgcuaagcgcaggaaaagaaaauaaccaugauucccucaguaacgugaagcgggaaaagcucaaauuugaaaucuggcaacauuucuuuuguuguccgaguuguaauuucaagaagcugcuuugaguguagacgaucggucuaaguuccuuggaacaggacgucagagagggugagaaccccgucuuuggucgauuggauaugccauauaaagcgcuuucgaagagucgaguugugcagcucuaaauggguggucaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguagagugaucgaaagaugaaaagaacuuugaaaagagaguuaaauaguacgugaaauugcugaaagcauuggaaaucagucuuaccugggugagaucaguagucucucgagacuaugcacucugaaccugugguaggucagcaucaguuuucgggggcggaaaaagaauaagggaagguggcuguuuauagcccuuguuguaauacguccacuggggacugaggacugcggcuucgugccaaggaugcugacauaaugguuuucaauggcccguccacggaccaaggagucuagcaucuaugcgaguguuugggugaugaaaacccauccgcgaggugggaacgcccuggcgugcaccaucagagcauagcuguugggacccgaaagauggugaaccaucuaguagcugguuccugccgaagagcagaaacucagaucaguuuuaaaugagaguuucuagugggccauuacuggcgaugcgggccgaacgugagguuaaggugccggaauguacgcuagaaagguguuaguuaacuagcccugggcgcuuaagcguacuacccauaccucaccgucuggguuagcuuugagaagcucagacgaguaggcaggcguggagguuugugacgaagccuugggcgugagccugggucgaacagccucuagugcagaucuugguggaaguagcagcgaaaccacagccugggggccaggucgucgcaaugguaauucaacuuaguacggaaccguugauucagaucauugguagagcuaucaucugccggauaacggcugagccagaauccgugccagagcgacgauauguauaaaaauagaggucucuccuguaucguagaagaugggcgaugguugaugaaacggaaguguuuuauugacuuguccaugaaauuccagaauccauugcauacgacuuuaauguggaacgggguauuguagauuaagccuuuguucccaagauuu ........................<<<<<<.>>>>>.>.........<<....>>..<<<<<......<<>>.....>>>>>..<<<..<<.......<<.<<<<<<<.......>>>>>>>.>>.......>>....<<<<<.<<<<<..<<<<<..<<<<<<<<<.....<<<<......>>>>.((......<<<.....))>>>......>>>>>>>>>..>>>>>.....>>>>>>>>.>>........<<<<<<..>>>>>>.....<<<<<..>>>>>..>>>..................................<<....>>...............<<<<....>>>>.............................<<<<<<<<<<<<.....<<<.<<<<.<<<.<<.<<<<<<<..>>>>>>>>>...>>>..>>>>..>>>..<<<<<<<.<<<<<<<<<<<<<<<.......<<<<<<<<......<...>......>>>>>>>>......>>>>>.>>>>>>>>>>........<<<.....>>>.....>>>>>>>....>>>>>>>>>>>>..<<<<..>>>><<<<<<...<<<<<<<.<<<<<<..<<<...<<<<.......>>>>...>>>...<<<<..<<<<<..>>>>>...>>>>....>>>>>>.>>>>>>>.<<.<...<<<<<<..>>>>>>......>.>>..<<<<<<.....<<<<<<<<.....<<<.<<...>>>>>..>>>>>>.>>..<<<<....>>>>....<<<.>>>...<<<<<<<...<<<(((.....<<<<<<.<<..<<<.<<<<<<..>>>>>>>>>.))).>>...>>>>>>.>>>...>>>>>>><<<<<<<<<............>>>>>>>>>....>>>>>>..<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.>>....>>....<<<<<...>>>>><<<<<<<..<<<<.<.<<<<<......<>.....>>>>>.><<<<<...<<<<...>>>>..>>>>>.<<<<....<<<<.>>>>....>>>>.>>>>..>>>>>>>.....<<.......<<<<..>>>>....>>........<<<<<....<<<<<<<<<<<<......>>>>>>>>>>>>..>>>>>.........<<<<<.<.............>.....<<<<<<<<<.<<<...>>>....>>>>.>>>>>...>>>>> ........................(.(((...)))..).........((....))...((((......(()).....))))...((((.........(((.(((((((.......))))))).))....)........((((..((((((.(((((...(((..(((...({((((......)))))[[(...).(((....}]])))......)))..)))...))))))....))))).)).))...)....(.((((())))).).....(((((())))))..)))..................................((....))............(..((((....))))............)................((((((((((((.....((((((((.((..((.(((((((..)))))))))....))..))))).)))..(((((((((((((((((((((((.......((((((((......(...)......))))))))......))))).))))))))))........(((.....)))....))))))))....))))))))))))..((((..))))((((((..(.((((((.((((((..(((..((((.........))))..)))..(((((..(((((..)))))...)))))...)))))).))))))..((.(...((((((..))))))......).))).((((((.....(((((..((....(((.((...))))).))..))).))..((((....))))....(((.)))...(((((((...((([[[...(.(((((...(...((.((((((()))))))))..]]].).....)))))))))...)))))))(((((((((............)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.))....)).[..(((((.].)))))(((((((..((((.(.(((((......().....))))).)(((((...((((...))))..))))).((((....(((...)))....)))).))))..)))))))...(.((.......(((....)))....))).......((((((...(((((((.((((......)))).))))))).)))))).........(((((....(.......)......(.((((((((..((.....)).....))).))))))..))))) Ytm1 associated 60S nascent ribosome State 1B; RNA (1263-MER) 8eth 2 130 3.8 RF00002 URS0000249ACE_4896 36423630 0003735 0002181 0005840,0022626 4896 aaacuuucagcaacggaucucuuggcucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugaaucaucgaaucuuugaacgcagcgccuuuaaaggcaugccuguuugagugucau .........................................<<<<<<<......>>>>.....<.<<<..........>>>..>...>>>....<<.>><<<<<..>>>>>................... .........................................(((((((......)))).....(.((((.......).)))..)...)))....((.))(((((())))))................... Ytm1 associated 60S nascent ribosome State 1B; RNA (130-MER) 8eti 1 1579 3.7 RF02543 URS0002617794_4896 36423630 0003735 0005840 4896 uugaccucaaaucagguaggacuacgcgcugauaagcgcaggaaaagaaaauaaccaugauucccucaguaacgugaagcgggaaaagcucaaauuugaaaucuggcaacauuucuuuuguuguccgaguuguaauuucaagaagcugcuuugaguguagacgaucggucuaaguuccuuggaacaggacgucagagagggugagaaccccgucuuuggucgauuggauaugccauauaaagcgcuuucgaagagucgaguugcagcucuaaauggguggucaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguagagugaucgaaagaugaaaagaacuuugaaaagagaguuaaauaguacgugaaauugcugaaagggaagcauuggaaaucagucuuaccugggugagaucaguagucucucgagacuaugcacucuaaccuggguaggucagcaucaguuuucgggggcggaaaaagaauaagggaagguggcuguuuauagcccuuguuguaauacguccacuggggacugaggacugcggcuucgugccaaggaugcugacauaaugguuuucaauggcccgucuaacacggaccaaggagucuagcaucuaugcgaguguuugggugaugaaaacccauccgcgaaggugggaacgcccuuguggcgugcaccaucgaaagagcauagcuguugggacccgaaagauggugaaccaucuaguagcugguuccugccgaaguuuccggauagcagaaacucagaucaguuuuaugaguauguaaaaugagaguuucuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacgugagguuaaggugccggaauguacgcucaucagaagaaaagguguuaguucaucuagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaugaacuagcccugaaaauggauggcgcuuaagcguacuacccauaccucaccgucuggguuagcuuugagaagcucagacgaguaggcaggcguggagguuugugacgaagccuugggcgugagccugggucgaacagccucuagugcagaucuugguggaaguagcagcgaaaccacagccuggggggccaggcaaaaucagcggcagucaagcgcgacguugcuuuccuaucauaccgaagcagaauucgguaagcgugggaacugaugaagugucgucgcaaugguaauucaacuuaguacgagaggaaccguugauucagaucauugguauuugcggcgccgcggagcuaucaucugccggauaacggcugaacgccucuaagccagaauccgugccagaaagcgacgaauguauaaaaauagagguaggcuacucuccuguaucguagaagaugggcgaugguugaugaaacggaaguguuuuauugacuuguccaugaaauuccaucgaauccauugcauacgacuuuaauguggaacgggguauuguaagcagcugcugagauuaagccuuuguucccaagauuug ........................<<<<<<....>>>>>.>.........<<....>>..<<<<<......<<>>.....>>>>>..<<<..<........<<.<<<<<<<.......>>>>>>>.>>........>....<<<<<.<<<<<..<<<<<..<<<<<<<<<.....<<<<......>>>>.((......<<<.....))>>>......>>>>>>>>>..>>>>>.....>>>>>>>>.>>........<<<<<<>>>>>>.....<<<<<..>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<<<<<.....<<<<<<<<.<<<.<<.<<<<<<<..>>>>>>>>>...>>>.>>>>>>>>..<<<<<<<<<<<<<<<<<<<<<<<........<<<<<<<.................>>>>>>>.......>>>>>.>>>>>>>>>>........<<<.....>>>....>>>>>>>>....>>>>>>>>>>>>..<<<<.....>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.......>>>>...>>>...<<<<<..<<<<<.....>>>>>...>>>>>......>>>>>>.>>>>>>..<<.<...<<<<<<..>>>>>>......>.>>..<<<<<<......<<..>>..<<<<<<<<<<...<<<.<<<<<<<....>>>>>>>>>>>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<......<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>...>>>>>>><<<<<<<<<............>>>>>>>>>....>>>>>>..<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.>>....>>....<<<<<....>>>>>....<<<<<.<<<<<<...<..>...>>>>>>.<<<...<.<<<<<<<......>>>>>>>...>.>>>..>>>>>......<<<<<<<..<<<<.<.<<<<<.................>>>>>.><<<<<....<.<....<<<<..>>>>...>.>...>>>>>.<<<<....<<<<...........>>>>....>>>>.>>>>....>>>>>>>....<<.......<<<<<<...>>.>>>>....>>........<<<<<....<<<<<<<<<<<<......>>>>>>>>>>>>..>>>>>..........<<<<<<.<.............>.....<<<<<<<<<.<<<....<<<..>>>...>>>....>>>>.>>>>>...>>>>>> ........................(.((((....))))..).........((....))...((((......(()).....))))...((((.........(((.(((((((.......))))))).))....)........((((..((((((.(((((...(((..(((...({((((......)))))[[(...).(((....}]])))......)))..)))...))))))....))))).)).))...)....(.(((()))).).....(((((())))))..)))..................................((....))............(..((((....))))............).....................((((((((((((........(((((.((..((.(((((((..)))))))))....)).))))).....(((((((((((((((((((((((.......((((((((......(...)......))))))))......))))).))))))))))........(((.....)))....))))))))....)))))))))))).[((((.....))))((((((..(.(.((((.((((((..(((...(((.........)))...)))...(((((..((((.(....)))))...)))))......)))))).)))).)..((.(...((((((..))))))......).))).((((((.......(())...(((((.((......((.(((((.(....).)))))))...)).))).))..((((.((..(.....)..)).))))....(((......)))...(((((((...((([[[...(.(((((.......(.......((.((((((((((.....{.(((((.(.(...((.........))...).).....(...((......)).).)))))...))))))))))))...........]]].).....)))))))))...)))))))(((((((((............)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.))....)).{..(((((.]}.)))))....(((((...((.....(()).....))....((.....(((((((......))))))..)...))...)))))......(((((....((((.(.(((((......(....).....))))).)(((((...((......((((()))))....).)..))))).((((....(((.....}.......)))....)))).))))......)))))....((.......(((...(.)....)))....))........((((((...((..((..((((......))))..))..)).))))))..........((((((.(..(.......)..)...(.(((((((((.(((....(((())))...)))....)))).))))))..)))))) Fkbp39 associated 60S nascent ribosome State 1; RNA (1564-MER) 8eti 2 152 3.7 RF00002 URS0000249ACE_4896 36423630 0003735 0002181 0005840,0022626 4896 aaacuuucagcaacggaucucuuggcucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaaugaaucaucgaaucuuugaacgcacauugcgccuuuggguucuaccaaaggcaugccuguuugagugucauu .........................................<<<<<<<<<....>>>>.....<.<<<......>>.........>>>..>...>>>....<<<...>>><<<<<<<<......>>>>>>>>.................... .........................................((((((.[[.....))).....(.((((...(.]].).....).)))..)...)))....((.....))((((((((......)))))))).................... Fkbp39 associated 60S nascent ribosome State 1; RNA (152-MER) 8etj 1 1817 3.2 RF02543 URS00026177A2_4896 36423630 0003735 0005840 4896 uugaccucaaaucagguaggacuacgcgcugaacaauaagcgcaggaaaagaaaauaaccaugauucccucaguaacggugaagcgggaaaagcucaaauuugaaaucuggcaacauuucuuuuguuguccgaguuguaauuucaagaagcugcuuugaguguagacgaucggucuaaguuccuuggaacaggacgucagagagggugagaaccccgucuuuggucgauuggauaugccauauaaagcgcuuucgaagagucgaguuguuugcagcucuaaaugggugguaaauuucaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguagagugaucgaaagaugaaaagaacuuugaaaagagaguuaaauaguacgugaaauugcugaaagggaagcauuggaaaucaggucagcaucaguuuucgggggcggaaaaagaauaagggaagguggcuuuccgggaguguuuauagcccuuguuguaauacguccacuggggacugaggacugcggcuucgugccaaggaugcugacauaaugguuuucaauggcccgucuacacggaccaaggagucuagcaucuaugcgaguguuugggugaugaaaacccauccgcgaaaugaaagugaaugcaggugggaacgcccuuguggcgugcaccaucgaccgacccggaaguauggaaggguuugaguaagagcauagcuguugggacccgaaagauggugaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaaacucagaucaguuuuaugaguauguaaaaugagaguuucuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacgugagguuaaggugccggaauguacgcucaucagaagaaaagguguuaguucaucuagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaugaacuagcccugaaaauggauggcgcuuaagcguacuacccauaccucaccgucuggguugaagcucagacgaguaggcaggcguggagguuugugacgaagccuugggcgugagccugggucgaacagccucuagugcagaucuugguggaaguagcauucaaaugagaacuuugaagacugaaguggggaaagguuccaugugaacagcaguuggacauggguuccaaggugaacagccucuaguugauagaacaauguagauaagggaagucggcaaaaugccacugucccuaucuacuaucuagcgaaaccacagccuggggaacgggccaggcaaaaucagcggggcuuguggcagucaagcggcgacauugcuuuccuaucauaccgaagcagaauucgguaagcguuggacccacuaauagggacuacugaugaagugucgucgcaaugguaauucaacuuaguacgagaggaaccguugauucagaucauugguauuugcggcugccugacaaggcaaugccgcggagcuaucaucugcuggauaacggcugaacgccucuaagccagaauccgugccagaaagcgacgauuuuuugguccgcaugauuuauauguauaaaaauagagguaggcuacucuccuguaucguagaagaugggcgaugguugaugaaacggaaguguuuuauugacuuguccaugaaauuccaaucuugugcggaaucgaauccauugcauacgacuuuaauguggaacgggguauuguaagcagcugcugagauuaagccuuuguucccaagauuug .........................<<<<<........>>>>>...........<<....>>..<<<<<......<<.>>.....>>>>>..<<<..<........<<.<<<<<<<.......>>>>>>>.>>........>....<<<<<.<<<<<..<<<<<...<<<<<<<<.....<<<<......>>>>.((......<<<.....))>>>......>>>>>>>>...>>>>>.....>>>>>>>>.>>........<<<<<<<..>>>>>>>.....<<<<<<......>>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<<<<<.<<<<<<<.<<<<<<<<<<<<<<<........<<<<<<<......<.<<<<..>>>>..>......>>>>>>>.......>>>>>.>>>>>>>>>>........<<<.....>>>.....>>>>>>>....>>>>>>>>>>>>..<<<<....>>>><<<<<<....<<<<<<.<<<<<<..<<<..<<<<<.......>>>>>..>>>...<<....>>.......<<<<<..<<<<<.....>>>>>...>>>>>.<<<<<<<<....<<>>....>>>.>>>.>>....>>>>>>.>>>>>>..<<.<...<<<<<<..>>>>>>......>.>>..<<<<<<.......<<....>>...<<<<<<<<<<...<<<.<<<<<<<....>>>>>>>>>>>>>>>>>>.>>..<<<<.<<.<<.....>>.>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<......<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.<<<<<<.......>>>>>><<<<<....<<<........<<<<<....<<.....>>..>>>>>..>>>.<<<<.....>>>>.>>>>>..<<<<.....<<<<<<<.<<.........<.........>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<.......<<<<<<...<<.>>...>>>>>><<<<<..<.<<<<<<<......>>>>>>>...>.<<<..>>>.....>>>>>.>.>>>>>.....<<<<<<<<..<<<<.<.<<<<<.................>>>>>.><<<<<...<<<<....<<<<<<<<<<....>>>>>..>>>>>...>>>>..>>>>>.<<<<....<<<<...........>>>>....>>>>.>>>>....>>>>>>>>.....<.<<<..<.<..........<<.......<<<<..<..>..>>>>....>>........<<<<<....<<<<<<<<<<<<......>>>>>>>>>>>>..>>>>>.............>.>..>>>.>.<<<<<.<.............>.....<<<<<<<<<.<<<....<<<..>>>...>>>....>>>>.>>>>>...>>>>>. ........................(.(((..........)))..).........((....))...((((......((.)).....))))...((((.........(((.(((((((.......))))))).))....)........((((..((((.(.(((((...(((..(((...({((((......)))))[[(...).(((....}]])))......)))..)))...)))))).....)))).)).))...)....(.(((((..))))).).....(((((........)))))..)))..................................((....))............(..((((....))))............).....................((((((((((((.(((((((((((((((((((((((.......(.((((((.........(((())))..........)))))).)......))))).))))))))))........(((.....)))....))))))))....))))))))))))..((((....))))((((((..(.((((((.((((((..(((...(((.........)))...)))...(......).......(.(((...((((.....))))....))).).((((((((....(..)....))).))).))....)))))).))))))..((.(...((((((..))))))......).))).((((((.......((....))....((((.((.....(((.(((((((....))))))))))..)).))).)...((((.((..(.....)..)).))))....(((......)))...(((((((...((([[[...(.(((((.......(.......((.((((((((((.....{.(((((.(.(...((.........))...).).........((......))...)))))...))))))))))))...........]]].).....)))))))))...)))))))(((((((((....)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.((((((.......))))))((((.....(((........((((((...((.....)).))))))..))).((((.....))))..))))..((((.....(((((((.((..(....(..........)..))).)))))))..))))))....)).[..(((((......].)))))....(((.(..((........((.(...((.))...).))..(((((..(.(((((((......))))))..).).(.(..).).....))))))).).))).....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((....)))))..)))))...))))..))))).((((....(((.....}.......)))....)))).))))....)))))))).....(..((.....(.......(.((.......(((...(())...)))....))).......((((.(....(...(.(((((......))))).)...)..).))))............).....))..).(((((.(..(.......)..)...(.(((((((((.(((....(((())))...)))....)))).))))))..))))). Fkbp39 associated 60S nascent ribosome State 2; RNA (1758-MER) 8etj 2 144 3.2 RF00002 URS0000249ACE_4896 36423630 0003735 0002181 0005840,0022626 4896 aaaacuuucagcaacggaucucuuggcucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaagaaucaucgaaucuuugaacgcacgcgccuuugggaccaaaggcaugccuguuugagugucau ..........................................<<<<<<<<<....>>>>.....<.<<<......>>........>>>..>...>>>....<<..>><<<<<<<<..>>>>>>>>................... ..........................................((((((.[[.....))).....(.((((...(.]].)....).)))..)...)))....((..))((((((((..))))))))................... Fkbp39 associated 60S nascent ribosome State 2; RNA (144-MER) 8eub B5 1782 2.52 RF01960,RF02542,RF01959,RF00177 URS0002681484_4932 37595043 0003735 0005840 4932 uaucugguugauccugccaguagucaunugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucnuuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauncaaggnaggcagcaggcgcgcnaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggnacaauuggagggcaagucugnugccagcagccgcggnaauuccagcuccaauagcguauauuaaaguuguugcaguunaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauungcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagancgaaaguuaggggaucgaagaugaucagauacngucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaangcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacncaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuuguggguggngnugcauggcnguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacangucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacnagnaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgnccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuucnguaggugnnccugcggaaggaucauu ...<<<<<.{.((((>>>>><<<<.<<<<<<...<.<...<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<..<<..<<....<<<..................<.....<<.<<<.....>>>.>>......>.........<<<<<............>>>>><...<<<<<<......(((.{((.<<<....>>>..............>>>>>>.....>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>..>>>..>....>.>.....<<..<<<................>>>...>>......<<..<...........>..>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>>>>>.........<<<[[.....<.<<...<<<.<<....<<<<<<.<<<<..............>>>>.>>>>>>......<<<.................................>>>.....<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........<<<..<<<<<<<<.....)).}))).>>>>>>>>.>>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>..>.>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<<.....>.>>>>>>>>>>>..>>>...<<..]]>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..)))).}<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<...<<<<<..>>>>>.....>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>......<....<<<<<<..........>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<...<<<<.<<<<....>>>>.>>>>...>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>........ ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((.....(..........)....)){))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((............)))))(.(.((((((......[[[.[.[.(((....))).....(......).)))))).)...).(.((((...(((..).))..)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(....(.....(......).....).....)......(.(.(...........))..).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.((..................)).))))))......((((.............(.....)...........)))).....(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(....(.(..((......]..]]]]..))..).)...).....))...(((..((.((...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)).))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((........((.(((........))).))......)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..(((...(((((..(((((....)))))....)))))...))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...((((..(.((((.((.(....).)).))))..).))))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>....... Hypopseudouridylated yeast 80S bound with Taura syndrome virus (TSV) internal ribosome entry site (IRES), eEF2 and GDP, Structure I; 18S rRNA 8eub A1 3198 2.52 RF02543 URS0002681478_4932 37595043 0003735 0005840 4932 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugnaacnnggaccaaggagunuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccnanagauggugancuaugccugaauagggugaagccagaggaaacucugguggaggcucguancgguucugncgugcaaaucgaucgucgaaunuggguauagnggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcngaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaunuuggugguagunncaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaanguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauunaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugccnagugcucugaaugucaaagugangaaauucaaccaagcgcggguaaacggcgggaguancuaugacucucuuaagguagcnannugccucnucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugunccuaucuacnaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcungacncuaguuugacauugugaagagacauagaggguguagaauaagugggagcuucggcgccagugaaauaccacuaccuuuauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcugnggcggcacaucugunaaacgnuaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauunucagngugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuanangugccagaaaaguuaccacagngauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuungaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggaunnuucacccacuaauagggaacgugngnuggguuuagancgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>...<.....<<....>>..<<<<<......<<.....>>.....>>>>>..<<<...<.......<<.<<<<<<...>>>>>>.>>.......>.....<<<<<<<.<<<<<<<.<..<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>>...>.>>>.....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>....>.............................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<......<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<....<.<<<<........>>>>>......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<<.............>>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<..........>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<......<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..[[[..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>............>>.>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<......>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<..<<<<<<<<<<.<<<<<<............<..........................>...>>>>>>..>>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))......<<<<<<<..<<<<.))))))>>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<....<<<<<<<<<<]]].>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.((((((((.(...((((((((...({((((......)))))[[(...).(((....}]])))....))))))))....).))).....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((........((........)).........))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((......(((....)))..((((((((((....((.(((((((.....(((....(((..(.((((...............)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(.(((.(.(...((.........))....)).....(...((......)).).))).)...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....))).........((.(.((...))..).)).....))....))...(((((........)))))]]((((..(((((.....((((....))).....<.((((((...((((.((((((((((((((((((...{{..))))))....(((((....(((((.....(((.....))).....))))).....))))).....(((((((......))))))))))).).))))))).))))(...)....))))))....).......)).))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((.(......).))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...((.....(((......))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.((..(.((((..........(..(..(......)............)..)..)))))...)).)))))))....((((.....((((..((((........))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((.(......(....).....).))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Hypopseudouridylated yeast 80S bound with Taura syndrome virus (TSV) internal ribosome entry site (IRES), eEF2 and GDP, Structure I; 28S rRNA 8eub A3 121 2.52 RF00001 URS000055688D_4932 37595043 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Hypopseudouridylated yeast 80S bound with Taura syndrome virus (TSV) internal ribosome entry site (IRES), eEF2 and GDP, Structure I; 5S rRNA 8eub A4 158 2.52 RF00002 URS00001BF64E_4932 37595043 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Hypopseudouridylated yeast 80S bound with Taura syndrome virus (TSV) internal ribosome entry site (IRES), eEF2 and GDP, Structure I; 5.8S rRNA 8eub EC 195 2.52 URS0000A76394_142102 37595043 142102 aaacuccauguauugguuacccaucugcaucgaaaacucuccgaacacuaggugcaguaaggcuuucauggagugguuugcuauuuagcguacguguaccauaggcagccccaaaaacacgugugaggagaaagucccagucacuuugggcaaaguagacagccgcgcuugcguggugggacuuaauuaaugccu ...<<<<<<...............<<<<<........(((((..........>>>>>..........>>>>>><<<...<<......>>.........>>>..<<.....>>..............)))))..<<..<.<<<<<<<.((((.>>>>.>>>..<<<<<....>>>>>..>.>>.........)))) ...((((((...............((((...........[[[...........))))..........))))))((((..((......)).....[.[))))..((.....))....].].......]]]...(.(.(..((((((..[[[[..))).)))..(((((....)))))...)).)........]]]] Hypopseudouridylated yeast 80S bound with Taura syndrome virus (TSV) internal ribosome entry site (IRES), eEF2 and GDP, Structure I; Taura syndrome virus (TSV) internal ribosome entry site (IRES) RNA 8eug 1 2869 2.8 RF02543 URS0002617799_4896 36423630 0003735 0005840 4896 uugaccucaaaucagguaggacuacgcgcugaacuuaagcauaucaauaagcgcaggaaaagaaaauaaccaugauucccucaguaacggcgagugaagcgggaaaagcucaaauuugaaaucuggcaacauuucuuuuguuguccgaguuguaauuucaagaagcugcuuugaguguagacgaucggucuaaguuccuuggaacaggacgucagagagggugagaaccccgucuuuggucgauuggauaugccauauaaagcgcuuucgaagagucgaguuguuugggaaugcagcucuaaaugggugguaaauuucaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguagagugaucgaaagaugaaaagaacuuugaaaagagaguuaaauaguacgugaaauugcugaaagggaagcauuggaaaucagucuuacguaggucagcaucaguuuucgggggcggaaaaagaauaagggaagguggcuguuuauagcccuuguuguaauacguccacuggggacugaggacugcggcuugccaaggaugcugacauaaugguuuucaauggcccgucuugaaacacggaccaaggagucuagcaucuaugcgaguguuugggugaaaaacccauccgcgaaaugaaagugaaugcaggugggaacgcccuggcgugcaccaucgaccgacccggaaguuugucaauggaaggguuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagagauucugacgugcaaaucgaucuucaaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaaacucagaucaguuuuaugagguaaagcgaaugauuagagguaccuauucucaaacuuuaaauauguaagacgcccuugucgcuuaauuggacgugggccaucgaaugagaguuucuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacgugagguuaaggugccggaauguacgcucaucagacaccagaaaagguguuaguucgaacuagcccugaaaauggauggcgcuuaagcguacuacccauaccucaccgucuggguuaagaagcucagacgaguaggcaggcguggagguuugugacgaagccuugggcgugagccugggucgaacagccucuagugcagaucuugguggaaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccaugugaacagcaguuggacauggguuagucgauccuaagagauagggaagcuccguaugaaaggcacgauuuuucgugccuaucgaaagggaauccgguuaauauuccggaaccagaagguggaaucaacacggcaacguaaaugaaguuggagacgucggcgggagcccugggaagaguucucuuuucuuuuuaacaaaccacacccugaaaucgguuuauccggagcuaggguaugguguuuggaagaguucagcggcugaauccggugcgcucucgacggcccuugaaaauccaacggaaguuguuuucacaucuggucguacucauaaccgcagcaggucuccaaggugaacagccucuaguugauagaacaauguagauaagggaagucggcaaaauggauccguaacuucgggauaaggauuggcucuaaggguaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggccagaaagugguguugacgcaaugugauuucugcccagugcucgaaugucaaagugaagaaauucaaccaagcgcggguaaacggcaagguagccaaaugccucgucaucuaacuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccuggggaacgggccaggcaaaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaauuuacuuaaucaaugaagcggaauuucuagcguuaaaguuucgcgaacugauccgcguugaugacauugucagguggggaguuuggcuggggcggcacaucuguuaaaagauaacgcagguguccuaagggggacucaucgagaaucucgaguagaauaaaaggguaaaaguccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuguucccucgaaauuugaggacagaggugccagaaaaguuaccacagggauaacuggcuucagccaagacguugcauucuucgaugucggcucuuccuaucauaccgaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaagugucgucgcaaugguaauucaacuuaguacgggaaccguugauucagaucauugguauuugcggcugccugacaaggcaaugccgcggagcuaucaucugccggauaacggcugagccagaauccgugccagaaagcgacgauuuauguauaaaaauagagguaacucuccuguaucguagaagaugggcgaugguugaacggaaguguuuugacuuguccaugaaauuccagaauccauugcauacgacuuuaauguggaacgggguauuguaagcaguagagucgaucugcugagauuaagccuuuguucccaagauuugu ........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..<<<...........<<.<<<<<<<.......>>>>>>>.>>.............<<<<<.<<<<<..<<<<<..<<<<<<<<<.....<<<<......>>>>.((......<<<.....))>>>......>>>>>>>>>..>>>>>.....>>>>>>>>.>>........<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<<<<.<...<<..>>.<<<<<<<.<<<<<<<<<<<<<<<.....<.<<<<<<<<......<...>......>>>>>>>>....>.>>>>>.>>>>>>>>>>........<<<..>>>.....>>>>>>>....>>>>>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<..>>>>>...>>>>>.<<<<<<<<....<<<....>>>....>>>.>>>.>>....>>>>>>.>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<..>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<..>>>>>>>>>>..........))).>>...>>>>>>.>>>...>>>>>>><<<<<<<<<......>>>>>>>>>....>>>>>>..<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<......>>>>>>..>>....>>...<<<<<........>>>>>))<<<<..<<<<<<<....<<<....>>>.....((<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<...[[..>>>>>>....<<<<<...<<<<<<....<<<.....>>>....>>>>>>.....>>>>>.....<<<<<<<.>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>.......>>>>.>>>.>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<...............>>>>><<.<<<<<<<<..>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<...<<..<<<<<<<..<<<....<<<<<....>>>>.>...>>>>>>>>..>>>>.......<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<..<<<<..>>>>...<<<<<.....<<<<..........))..<<<<<...>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.>>>>>>.....<<...(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>>.<<<....>>>.>>)))......<<<<<<<..<<<<.))))))>>>>>>>>>>>.........>>>>..>>>>>>.......<<...<<<<......>>>>..>.>.......<<<<<.<<<<<<..<.<<<<<<..>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<<<..<<<<...<<<<<..............>>>>>..<<<<<...<<<<....<<<<<<<<<<]]..>>>>>..>>>>>...>>>>..>>>>>.<<<<....<<<<.>>>>....>>>>.>>>>....>>>>>>>>......<<.......<<<<....>>>>....>>........<<<<<....<<<<.<<<......>>>..>>>>..>>>>>.........<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<.>...>>>>...>>>....>>>>.>>>>>...>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.(((((((.......))))))).))....)........(((((.((((((.(((((..((((.((((...({((((......)))))[[(...).(((....}]])))......)))).))))..))))))....)))))))).))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((((((....((..)).(((((((((((((((((((((((.......(.((((((......(...)......)))))).)......))))).))))))))))........(((..)))....))))))))....)))))))))))).[((((........))))((((((....((((((.((((((..(((..((((.......))))..)))...((....)).......((.((...((((..))))....)).)).((((((((....(((....)))....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((........)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.(((..))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))))))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.(((((((()))))))))))..........]]].)....))))))))))...)))))))(((((((((......)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((..(((((((...((.....)).))))))....[[(((.((...((....(((....)))........((((((......))))))..))....))...(((((........)))))]]((((..(((((((...((((....)))...(...((((((...((((.((((((((((((((((((...{{..))))))(...(((((...(((((.....(((.....))).....))))).....)))))....)(((((((.))))))))))).).))))))).))))(...)....))))))...))..)))).))).)))).))).))).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((..))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..(((((((...((.....((((....)))).....)).)))))..)))))......((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..((((()))))...(((((.....((((..............((((.....))))..))))..))))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....(((((.(.((((.]]]]]]))))))))))....)}....))))..)))))).......((...((((......))))..).)........((((.((((((..(.((((((..)))))..).).(((.........))).....)))))..)...))).).....(((((((....))).))))....))..))).))))).....((((((((..((((.(.(((((......(.).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((....(((...)))....)))).))))....))))))))....(.((.......((((....))))....))).......((((((...((.(.(((......)))..).)).)))))).........(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(.)..)))))...)))....)))).))))))..))))).. Ytm1 associated nascent 60S ribosome State 3; RNA (2863-MER) 8eug 2 151 2.8 RF00002 URS0000249ACE_4896 36423630 0003735 0002181 0005840,0022626 4896 aaaacuuucagcaacggaucucuuggcucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaagaaucaucgaaucuuugaacgcacauugcgccuuuggguucuaccaaaggcaugccuguuugagugucau ..........................................<<<<<<.<<.....>>>.....(.<<<......>>........>>>..)...>>>....<<.....>><<<<<<<<......>>>>>>>>................... ..........................................((((((.[[.....))).....(.((((.....]]......).)))..)...)))....((.....))((((((((......))))))))................... Ytm1 associated nascent 60S ribosome State 3; RNA (152-MER) 8eug 9 118 2.8 RF00001 URS000024F61C_4896 36423630 0003735 0002181 0005840,0022626 4896 gucuacggccauaccuaggcgaaaacaccaguucccguccgaucacugcaguuaagcgucugagggccucguuaguacuaugguuggagacaacaugggaauccggggugcuguaggc <<<<<<<<<....<<<<<<<<.....<<<<<<............>>>>..>>....>>>>>>.>><<<<<<......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>> (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......(((((..((....)).))))).....))))))))))))))) Ytm1 associated nascent 60S ribosome State 3; RNA (118-MER) 8eui 1 2855 3.1 RF02543 URS0002617799_4896 36423630 0003735 0005840 4896 uugaccucaaaucagguaggacuacgcgcugaacuuaagcauaucaauaagcgcaggaaaagaaaauaaccaugauucccucaguaacggcgagugaagcgggaaaagcucaaauuugaaaucuggcaacauuucuuuuguuguccgaguuguaauuucaagaagcugcuuugaguguagacgaucggucuaaguuccuuggaacaggacgucagagagggugagaaccccgucuuuggucgauuggauaugccauauaaagcgcuuucgaagagucgaguuguuugggaaugcagcucuaaaugggugguaaauuucaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguagagugaucgaaagaugaaaagaacuuugaaaagagaguuaaauaguacgugaaauugcugaaagggaagcauuggaaaucagucuuauaggucagcaucaguuuucgggggcggaaaaagaauaagggaagguggcuguuuauagcccuuguuguaauacguccacuggggacugaggacugcggcuugccaaggaugcugacauaaugguuuucaauggcccgucuugaaacacggaccaaggagucuagcaucuaugcgaguguuugggugaaaaacccauccgcgaaaugaaagugaaugcaggugggaacgcccuggcgugcaccaucgaccgacccggaaguuugucaauggaaggguuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagagauucugacgugcaaaucgaucuucaaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaaacucagaucaguuuuaugagguaaagcgaaugauuagagguaccuauucucaaacuuuaaauauguaagacgcccuugucgcuuaauuggacgugggccaucgaaugagaguuucuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacgugagguuaaggugccggaauguacgcucaucagacaccagaaaagguguuaguucgaacuagcccugaaaauggauggcgcuuaagcguacuacccauaccucaccgucuggguuaagaagcucagacgaguaggcaggcguggagguuugugacgaagccuugggcgugagccugggucgaacagccucuagugcagaucuugguggaaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccaugugaacagcaguuggacauggguuagucgauccuaagagauagggaagcuccguaugaaaggcacgauuuuucgugccuaucgaaagggaauccgguuaauauuccggaaccagaagguggaaucaacacggcaacguaaaugaaguuggagacgucggcgggagcccugggaagaguucucuuuucuuuuuaacaaaccacacccugaaaucgguuuauccggagcuaggguaugguguuuggaagaguucagcggcugaauccggugcgcucucgacggcccuugaaaauccaacggaaguguuuucacaucuggucguacucauaaccgcagcaggucuccaaggugaacagccucuaguugauagaacaauguagauaagggaagucggcaaaauggauccguaacuucgggauaaggauuggcucuaaggguaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggccagaaagugguguugacgcaaugugauuucugcccagugcucgaaugucaaagugaagaaauucaaccaagcgcggguaaacggcaagguagccaaaugccucgucaucuaacuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccuggggaacgggccaggcaaaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaauuacuuaaucaaugaagcggaauuucuagcguuaaaguuucgcgaacugauccgcguugaugacauugucagguggggaguuuggcuggggcggcacaucuguuaaaagauaacgcagguguccuaagggggacucaucgagaaucucgaguagaauaaaaggguaaaaguccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuguucccucgaaauuugaggacagaggugccagaaaaguuaccacagggauaacuggcuucagccaagacguugcauucuucgaugucggcucuuccuaucauaccgaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaagugucgucgcaaugguaauucaacuuaguacgggaaccguugauucagaucauugguauuugcggcugccugacaaggcaaugccgcggagcuaucaucugccggauaacggcugagccagaauccgugccagaaagcgacgauuuauguauaaaaauagaguccuguaucguagaagaugggcgaugguugaacggaaguguuuugacuuguccaugaaauuccagaauccauugcauacgacuuuaauguggaacgggguauuguaagcaguagagaucugcugagauuaagccuuuguucccaagauuugu ........................<<<<<<.....<......>......>>>>>.>...<.....<<....>>..<<<<<......<<.....>>.....>>>>>..<<<...........<<.<<<<<<<.......>>>>>>>.>>.............<<<<<.<<<<<..<<<<<..<<<<.<<<<.....<<<<......>>>>.((......<<<.....))>>>......>>>>.>>>>..>>>>>.....>>>>>>>>.>>........<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>....>.............................<<....>>...............<<<<....>>>>..................................<<<<<<<<<<<.<...<..>.<<<<<<<.<<<<<<<<<<<<<<<.....<.<<<<<<<<.....<....>......>>>>>>>>....>.>>>>>.>>>>>>>>>>........<<<..>>>.....>>>>>>>....>>>>>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<..>>>>>...>>>>>.<<<<<<<<....<<<....>>>....>>>.>>>.>>....>>>>>>.>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<..>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<......<..........<<<.<<<<<<<..>>>>>>>>>>..........))).>....>>>>>>.>>>...>>>>>>><<<<<<<<<......>>>>>>>>>....>>>>>><.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<....<<.....>>..>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<......>>>>>>..>>....>>...<<<<<........>>>>>))<<<<..<<<<<<<....<<<....>>>.....((<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<...[[..>>>>>><...<<<<<...<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<.>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>......>>>>.>>>.>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<....<....>.....>>>>><<.<<<<<<<<..>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<...<<..<<<<<<<..<<<....<<<<<....>>>>.>...>>>>>>>>..>>>>.......<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<..<<<...>>>...<<<<<.....<<<<..........))..<<<<<...>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))......<<<<<<<..<<<<.))))))>>>>>>>>>>>.........>>>>..>>>>>>.......<<...<<<<......>>>>..>.>.......<<<<<.<<<<<<..<.<<<<<<..>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<<<..<<<<...<<<<<..............>>>>>..<<<<<...<<<<....<<<<<<<<<<]]..>>>>>..>>>>>...>>>>..>>>>>.<<<<....<<<<.>>>>....>>>>.>>>>....>>>>>>>>......<<.......<<.>>....>>........<<<<<....<<<<.<<<......>>>..>>>>..>>>>>.........<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<.<....>>>>>...>>>....>>>>.>>>>>...>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.(((((((.......))))))).))....)........(((((.((((((.(((((..((((.((((...({((((......)))))[[(...).(((....}]])))......)))).))))..))))))....)))))))).))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((((((....(()).(((((((((((((((((((((((.......((((((((......(...)......))))))))......))))).))))))))))........(((..)))....))))))))....)))))))))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......((.((...((((..))))....)).)).((((((((....(((....)))....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.(((()))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))))))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.(((((((()))))))))))..........]]].)....))))))))))...)))))))(((((((((......)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((..(((((((...((.....)).))))))....[[(((.((...((....(((....))).........(((((......)))))...))....))...(((((........)))))]]((((..(((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((...(((((.....(((.....))).....))))).....)))))....)(((((((.))))))))))).).))))))).))))(...)....))))))...)).)))).))).)))).))).))).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((....)..)))))).))............(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((....(......((((....))))......)..))))..)))))......((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..((((.))))...(.(.(.....((((...........>...((((...))))...))))..).).).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((...((((......))))..).)........((((.((((((..(.((((((..)))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).))))).....((((((((..((((.(.(((((......(.).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((....(((...)))....)))).))))....))))))))....(.((.......((.))....))).......((((((...((.(.(((......)))..).)).)))))).........(((((.(..(.......)..)...(.(((((((((.(((....((((.(....)))))...)))....)))).))))))..))))).. Ytm1 associated nascent 60S ribosome (-fkbp39) State 3; RNA (2863-MER) 8eui 2 158 3.1 RF00002 URS0000249ACE_4896 36423630 0003735 0002181 0005840,0022626 4896 aaaacuuucagcaacggaucucuuggcucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccuuuggguucuaccaaaggcaugccuguuugagugucauu ..........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<......>>>>>>>>.................... ..........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))((((((((......)))))))).................... Ytm1 associated nascent 60S ribosome (-fkbp39) State 3; RNA (152-MER) 8eui 9 118 3.1 RF00001 URS000024F61C_4896 36423630 0003735 0002181 0005840,0022626 4896 gucuacggccauaccuaggcgaaaacaccaguucccguccgaucacugcaguuaagcgucugagggccucguuaguacuaugguuggagacaacaugggaauccggggugcuguaggc <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>> (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......(((((..((....)).))))).....))))))))))))))) Ytm1 associated nascent 60S ribosome (-fkbp39) State 3; RNA (118-MER) 8eup 1 1422 3.1 RF02543 URS000261779F_4896 36423630 0003735 0005840 4896 uugaccucaaaucagguaggacuacgcgcugaacaauaagcgcaggaaaagaaaauaaccaugauucccucaguaacggugaagcgggaaaagcucaaauuugaaaucuggcaacauuucuuuuguuguccgaguuguaauuucaagaagcugcuuugaguguagacgaucggucuaaguuccuuggaacaggacgucagagagggugagaaccccgucuuuggucgauuggauaugccauauaaagcgcuuucgaagagucgaguuguuugcagcucuaaauggguggucaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguagagugaucgaaagaugaaaagaacuuugaaaagagaguuaaauaguacgugaaauugcugaaagggaagcauuggaaaucagucuuaccugggugagaucaguagucucucgagacuaugcacucugaaccugugguaggucagcaucaguuuucgggggcggaaaaagaauaagggaagguggcuguuuauagcccuuguuguaauacguccacuggggacugaggacugcggcuugccaaggaugcugacauaaugguuuucaauggcccgucuugaaacacggaccaaggagucuagcaucuaugcgaguguuugggugaugaaaacccauccgcgaaggugggaacgcccuuguggcgugcaccaucgaagagcauagcuguugggacccgaaagauggugaaccaucuaguagcugguuccugccgaaguuuccggauagcagaaacucagaucaguuuuauguguaaaaugagaguuucuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacgugagguuaaggugccggaauguacgcucaucagaaagguguuaguucauaugaacuagcccugggcgcuuaagcguacuacccauaccucaccgucuggguuagcuuugagaagcucagacgaguaggcaggcguggagguuugugacgaagccuugggcgugagccugggucgaacagccucuagugcagaucuugguggaaguagcuagaucuagcgaaaccacagccuggggaacgggccaggcaaucgucgcaaugguaauucaacuuaguacgagaggaaccguugauucagaucauugguauuugcggccgcggagcuaucaucugccggauaacggcugaacgccucuaagccagaauccgugccagaaagcgacgauuauguauaaaaauagagguaggcuacucuccuguaucguagaagaugggcgaugguugaugaaacggaaguguuuuauugacuuguccaugaaauuccaugaauccauugcauacgacuuuaauguggaacgggguauugagauuaagccuuuguucccaagauuug .........................<<<<<........>>>>>...........<<....>>..<<<<<......<<.>>.....>>>>>..<<<...<.......<<.<<<<<<<.......>>>>>>>.>>.......>.....<<<<<.<<<<<..<<<<<..<<<<<<<<<.....<<<<......>>>>.((......<<<.....))>>>......>>>>>>>>>..>>>>>.....>>>>>>>>.>>........<<<<<<<..>>>>>>>.....<<<<<..>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<<<<<.....<<<.<<<<.<<<.<<.<<<<<<<..>>>>>>>>>...>>>..>>>>..>>>..<<<<<<<.<<<<<<<<<<<<<<<..........<<<<<.................>>>>>.........>>>>>.>>>>>>>>>>........<<<..>>>.....>>>>>>>....>>>>>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.......>>>>...>>>...<<<<<..<<<<<.....>>>>>...>>>>>.....>>>>>>.>>>>>>..<<.<..<<<<<<<..>>>>>>>.....>.>>..<<<<<<......<<..>>..<<<<<<<<<....<<<.<<<<<<..>>>>>>>>>.>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<..<<<.<<<<<<<<<..>>>>>>>>>>>>.))).>>...>>>>>>.>>>...>>>>>>><<<<<<<<<............>>>>>>>>>....>>>>>>..<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>........>>>>>><<.....<<<<<..>>>>>....>>....<<<<<........>>>>>...<<<<<<<..<<<<...<<<<<.................>>>>>..<<<<<...<<<<....<<<..>>>...>>>>..>>>>>.<<<<....<<<<...........>>>>....>>>>.>>>>....>>>>>>>......<<.......<<<<..<..>..>>>>....>>........<<<<<....<<<<<<<<<<<<......>>>>>>>>>>>>..>>>>>..........<<<<<.<.............>.....<<<<<<<<<.<<<..>>>....>>>>.>>>>>...>>>>>. ........................(((((..........)))).).........((....))...((((......((.)).....))))...((((.........(((.(((((((.......))))))).))....)........(((((.((((((.(((((..(((((((((...({((((......)))))[[(...).(((....}]])))......)))))))))..))))))....)))))))).))...)....(((((((..))))))).....(((((..)))))..)))..................................((....))............(..((((....))))............).....................((((((((.(((.....((((((((.((..((.(((((((..)))))))))....))..))))).)))..(((((((((((((((((((((((.......(..(((((.................)))))..)......))))).))))))))))........(((..)))....))))))))....))).)))))))).{((((........))))((((((....((((((.((((((..(((..((((.........))))..)))...(((((..(((((.....)))))...))))).....)))))).))))))..((.(...((((((..))))))......).))..((((((....(.((..)).)(((((((((....(((.(((((.().)))))))).))))))).))..((((.((.((.....)).)).))))....(((......)))...(((((((...((([[[...(.((((((......(..(((.(((((((((())))))))))))).]]].)....))))))))))...)))))))(((((((((............)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....(((((())))))....)).[..(((((.....}].)))))...(((((((..(((..(.(((((......(....).....))))).)(((((.....(.....(((())))....)....))))).((((....(((.............)))....))))..)))....)))))))....(.((.......(((....()....)))....))).......((((((...((((((((((((......)))))))))))).))))))..........(((((.(..(.......)..)...(.((((((((..(((..))).....))).))))))..))))). Ytm1 associated 60S nascent ribosome State 1A; RNA (1422-MER) 8eup 2 146 3.1 RF00002 URS0000249ACE_4896 36423630 0003735 0002181 0005840,0022626 4896 aaaacuuucagcaacggaucucuuggcucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaagaaucaucgaaucuuugaacgcacugcgccuuugggaccaaaggcaugccuguuugagugucauu ..........................................<<<<<<<<.....>>>>.....<.<<<.......>........>>>..>...>>>....<<...>><<<<<<<<..>>>>>>>>.................... ..........................................((((((.[[.....))).....(.((((.....]]......).)))..)...)))....((...))((((((((..)))))))).................... Ytm1 associated 60S nascent ribosome State 1A; RNA (146-MER) 8euy 1 1433 3.0 RF02543 URS000261779C_4896 36423630 0003735 0005840 4896 uugaccucaaaucagguaggacuacgcgcugaacaauaagcgcaggaaaagaaaauaaccaugauucccucaguaacggagugaagcgggaaaagcucaaauuugaaaucuggcaacauuucuuuuguuguccgaguuguaauuucaagaagcugcuuugaguguagacgaucggucuaaguuccuuggaacaggacgucagagagggugagaaccccgucuuuggucgauuggauaugccauauaaagcgcuuucgaagagucgaguuguuugcagcucuaaaugggugguaucaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguagagugaucgaaagaugaaaagaacuuugaaaagagaguuaaauaguacgugaaauugcugaaagggaagcauuggaaaucagucuuaccugggugagaucaguagucucucgagacuaugcacucugaaccugugguaggucagcaucaguuuucgggggcggaaaaagaauaagggaagguggcguguuuauagccuuguuguaauacguccacuggggacugaggacugcggcuucgugccaaggaugcugacauaaugguuuucaauggcccgucuugaaacacggaccaaggagucuagcaucuaugcgaguguuugggugaugaaaacccauccgcgaagugggaacgcccuuguggcgugcaccagagcauagcuguugggacccgaaagauggugagaaccaucuaguagcugguuccugccgaaguuuccggauagcagaaacucagaucaguuuuaugaguauguaaaaugagaguuucuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacgugagguuaaggugccggaauguacgcucaucagacgaaaagguguuaguucaugaacuagcccugggcgcuuaagcguacuacccauaccucaccgucuggguuagcuuugagaagcucagacgaguaggcaggcguggagguuugugacgaagccuugggcgugagccugggucgaacagccucuagugcagaucuugguggaaguagcucuagcgaaaccacagccuggggaacgggccaggucgucgcaaugguaauucaacuuaguacgagaggaaccguugauucagaucauugguauuugcgcggagcuaucaucugcuggauaacggcugaacgccucuaagccagaauccgugccagaaagcgacgagguccgcauauguauaaaaauagagguaggcuacucuccuguaucguagaagaugggcgaugguugaugaaacggaaguguuuuauugacuuguccaugaaauuccaugugcggaaucgaauccauugcauacgacuuuaauguggaacgggguauugagauucuuuguucccaagauuug ........................<<<<<<........>>>>>.>.........<<....>>..<<<<<......<<...>>.....>>>>>..<<<..<<.......<<.<<<<<<<.......>>>>>>>.>>.......>>....<<<<<.<<<<<..<<<<<..<<<<<<<<<.....<<<<......>>>>.((......<<<.....))>>>......>>>>>>>>>..>>>>>.....>>>>>>>>.>>........<<<<<<<..>>>>>>>.....<<<<<<..>>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<<<<<.....<<<.<<<<.<<<.<<.<<<<<<<..>>>>>>>>>...>>>..>>>>..>>>..<<<<<<<.<<<<<<<<<<<<<<<.......<<<<<<<.......<..>........>>>>>>>......>>>>>.>>>>>>>>>>........<<<.....>>>.....>>>>>>>....>>>>>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.......>>>>...>>>...<<<....<<<....>>>.....>>>....>>>>>>.>>>>>>..<<.<...<<<<<<....>>>>>>......>.>>..<<<<<<....<.<<..>>.><<<<<<<<<<...<<<.<<<<<<<....>>>>>>>>>>>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<......<......<<<.<<<<<<<<..>>>>>>>>>>>.))).>....>>>>>>.>>>...>>>>>>><<<<<<<<<............>>>>>>>>>....>>>>>><.<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>..>.....>>>>>><<.....<<....>>....>>....<<<<<........>>>>><<<<<<<..<<<<.<.<<<<<.................>>>>>.><<<<<...<<<<....<..>...>>>>..>>>>>.<<<<....<<<<...........>>>>....>>>>.>>>>....>>>>>>><.<<<<<<<....<<.......<<<<.<<.>>..>>>>....>>........<<<<<.....<<<<<<<<<<<......>>>>>>>>>>>...>>>>>..........>>>>>>>.><<<<<<.....................<<<<<<<...<<....>>..>>.>>>>>...>>>>>> ........................(.(((..........)))..).........((....))...((((......((...)).....))))...((((.........(((.(((((((.......))))))).))....)........((((..((((((.(((((...(((..(((...({((((......)))))[[(...).(((....}]])))......)))..)))...))))))....))))).)).))...)....(.(((((..))))).).....(((((....)))))..)))..................................((....))............(..((((....))))............).....................((((((((((((.....((((((((.((..((.(((((((..)))))))))....))..))))).)))..(((((((((((((((((((((((.......(...(((........().........)))...)......))))).))))))))))........(((.....)))....))))))))....)))))))))))).{((((........))))((((((..(.((((((.((((((..(((...(((.........)))...))).....(....(.(....).).....)......)))))).))))))..((.(...((((((....))))))......).))).((((((....(.((..)).).((((((((....(((.(((((.(....).)))))))).))))))).)...((((.((.((.....)).)).))))....(((......)))...(((((((...((([[[...(.((((((......(......(((.(.((((((..)))))).)))).]]].)....))))))))))...)))))))(((((((((............)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((....))....)).[..(((((.....}].)))))(((((((..((((.(.(((((......(....).....))))).)(.(((...(((.....(..)....)))..))).).((((....(((.............)))....)))).))))....)))))))(.(((((((..(.((.......(((...(.)....)))....))).......((((((....(((((((((((......)))))))))))..))))))..........))))))).)(.((((.(..(.......)..)......(((((((..((....)).))).))))....)))).) Ytm1 associated nascent 60S ribosome (-fkbp39) State 1A; RNA (1095-MER) 8euy 2 130 3.0 RF00002 URS0000249ACE_4896 36423630 0003735 0002181 0005840,0022626 4896 aaacuuucagcaacggaucucuuggcucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugaaucaucgaaucuuugaacgcacugcgccuuaaggcaugccuguuugagugucau .........................................<<<<<<<......>>>>.....<.<<<..........>>>..>...>>>....<<<.>>><<<<..>>>>................... .........................................(((((((......)))).....(.((((.......).)))..)...)))....(((.)))((((()))))................... Ytm1 associated nascent 60S ribosome (-fkbp39) State 1A; RNA (148-MER) 8ev3 1 1452 3.0 RF02543 URS000261779F_4896 36423630 0003735 0005840 4896 uugaccucaaaucagguaggacuacgcgcugaacaauaagcgcaggaaaagaaaauaaccaugauucccucaguaacggugaagcgggaaaagcucaaauuugaaaucuggcaacauuucuuuuguuguccgaguuguaauuucaagaagcugcuuugaguguagacgaucggucuaaguuccuuggaacaggacgucagagagggugagaaccccgucuuuggucgauuggauaugccauauaaagcgcuuucgaagagucgaguuguuugcagcucuaaauggguggucaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguagagugaucgaaagaugaaaagaacuuugaaaagagaguuaaauaguacgugaaauugcugaaagggaagcauuggaaaucagucuuaccugggugagaucaguagucucucgagacuaugcacucugaaccugugguaggucagcaucaguuuucgggggcggaaaaagaauaagggaagguggcuguuuauagcccuuguuguaauacguccacuggggacugaggacugcggcuugccaaggaugcugacauaaugguuuucaauggcccgucuugaaacacggaccaaggagucuagcaucuaugcgaguguuugggugaugaaaacccauccgcgaagugggaacgcccuuguggcgugcaccaucagagcauagcuguugggacccgaaagauggugaaccaucuaguagcugguuccugccgaaguuuccggauagcagaaacucagaucaguuuuaugaguauguaaaaugagaguuucuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacgugagguuaaggugccggaauguacgcucaucagacgaaaagguguuaguucauaugaacuagcccugggcgcuuaagcguacuacccauaccucaccgucuggguuagcuuugagaagcucagacgaguaggcaggcguggagguuugugacgaagccuugggcgugagccugggucgaacagccucuagugcagaucuugguggaaguagcuagaucuagcgaaaccacagccuggggaacgggccaggcucauaccgaagcagaauucgguaagcucgucgcaaugguaauucaacuuaguacgagaggaaccguugauucagaucauugguauuugcggccgcggagcuaucaucugccggauaacggcugaacgccucuaagccagaauccgugccagaaagcgacgauuauguauaaaaauagagguaggcuacucuccuguaucguagaagaugggcgaugguugaugaaacggaaguguuuuauugacuuguccaugaaauuccaugaauccauugcauacgacuuuaauguggaacgggguauuguagauuaagccuuuguucccaagauuug ........................<<<<<<........>>>>>.>.........<<....>>..<<<<<......<<.>>.....>>>>>..<<<..<<.......<<.<<<<<<<.......>>>>>>>.>>.......>>....<<<<<.<<<<<..<<<<<..<<<<<<<<<.....<<<<......>>>>.((......<<<.....))>>>......>>>>>>>>>..>>>>>.....>>>>>>>>.>>........<<<<<<<..>>>>>>>.....<<<<<..>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<<<<<.....<<<.<<<<.<<<.<<.<<<<<<<..>>>>>>>>>...>>>..>>>>..>>>..<<<<<<<.<<<<<<<<<<<<<<<.........<<<<<<.................>>>>>>........>>>>>.>>>>>>>>>>........<<<..>>>.....>>>>>>>....>>>>>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.......>>>>...>>>...<<<<..<<<<<.....>>>>>...>>>>....>>>>>>.>>>>>>..<<.<..<<<<<<<..>>>>>>>.....>.>>..<<<<<<....<.<<..>>.><<<<<<<<<....<<<.<<<<<<<....>>>>>>>>>>.>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<......<<<.<<<<<<<<<..>>>>>>>>>>>>.))).>>...>>>>>>.>>>...>>>>>>><<<<<<<<<............>>>>>>>>>....>>>>>>..<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>........>>>>>><<.....<<<<<..>>>>>....>>....<<<<<........>>>>>....<<<<<<<......>>>>>>>...<<<<<<<..<<<<.<.<<<<<.................>>>>>.><<<<<....<<<....<<<..>>>...>>>...>>>>>.<<<<....<<<<...........>>>>....>>>>.>>>>....>>>>>>>......<<.......<<<<..<..>..>>>>....>>........<<<<<....<<<<<<<<<<<<......>>>>>>>>>>>>..>>>>>..........<<<<<.<.............>.....<<<<<<<<<.<<<...>>>....>>>>.>>>>>...>>>>>. ........................(((((..........)))).).........((....))...((((......((.)).....))))...((((.........(((.(((((((.......))))))).))....)........(((((.((((((.(((((..(((((((((...({((((......)))))[[(...).(((....}]])))......)))))))))..))))))....)))))))).))...)....(((((((..))))))).....(((((..)))))..)))..................................((....))............(..((((....))))............).....................((((((((((((.....((((((((.((..((.(((((((..)))))))))....))..))))).)))..(((((((((((((((((((((((.......(..(((((.................)))))..)......))))).))))))))))........(((..)))....))))))))....)))))))))))).{((((........))))((((((..(.((((((.((((((..(((...(((.........)))...)))...((((..(((((.....)))))...))))....)))))).))))))..((.(...((((((..))))))......).))).((((((....(.((..)).)(((((((((....(((.(((((.(....).)))))))).))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(......(((.(((((((((())))))))))))).]]].)....))))))))))...)))))))(((((((((............)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....(((((())))))....)).[..(((((.....}].)))))....(((((((......))))))..).(((((((..((((.(.(((((......(....).....))))).)(((((.....(.....(((())))....)....))))).((((....(((.............)))....)))).))))....)))))))....(.((.......(((....()....)))....))).......((((.(...((((((((((((......)))))))))))).).))))..........(((((.(.............)...(.((((((((..((.....)).....))).))))))..))))). Ytm1 associated 60S nascent ribosome (-Fkbp39) State 1B; RNA (1452-MER) 8ev3 2 150 3.0 RF00002 URS0000249ACE_4896 36423630 0003735 0002181 0005840,0022626 4896 aaaacuuucagcaacggaucucuuggcucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaagaaucaucgaaucuuugaacgcacugcgccuuuggguucuaccaaaggcaugccuguuugagugucauu ..........................................<<<<<<<<.....>>>>.....<.<<<.......>........>>>..>...>>>....<<...>><<<<<<<<......>>>>>>>>.................... ..........................................((((((.[[.....))).....(.((((.....]]......).)))..)...)))....((...))((((((((......)))))))).................... Ytm1 associated 60S nascent ribosome (-Fkbp39) State 1B; RNA (150-MER) 8ev6 1A 2871 2.946 RF02541 URS00001698E8_300852 37537169 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<.....<<<........>>>......>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..<<......(..>>...>>>.........<<......>>.).>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((...((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((.(..(((..........)..)))..)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((..((.........))...))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(......[..(((((..(((......((((((((....))))))))...)))..........].)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((...)))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with amikacin, mRNA, and A-, P-, and E-site tRNAs; 23S Ribosomal RNA 8ev6 1B 120 2.946 RF00001 URS000080DEE8_300852 37537169 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>. .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the Thermus thermophilus 70S ribosome in complex with amikacin, mRNA, and A-, P-, and E-site tRNAs; 5S Ribosomal RNA 8ev6 1a 1500 2.946 RF00177,RF01959,RF02542,RF01960 URS000080DFED_300852 37537169 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>.<..<<......>>.>..>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((((((....))))))).)))))......(((......((((((((..((...(((((((.(((((.....(((((....)))))......)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((.(((....))).)))....(((....)))....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the Thermus thermophilus 70S ribosome in complex with amikacin, mRNA, and A-, P-, and E-site tRNAs; 16S Ribosomal RNA 8ev6 1v 13 2.946 37537169 10665 aaaaauguucuaa ............. ............. Crystal structure of the Thermus thermophilus 70S ribosome in complex with amikacin, mRNA, and A-, P-, and E-site tRNAs; mRNA 8ev6 1w 74 2.946 RF00005 URS00005AA258_562 37537169 0030533 0006412 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<......>>>><<<<<<<.....>>>>>>.>...<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[..)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with amikacin, mRNA, and A-, P-, and E-site tRNAs; A-site and E-site tRNAs 8ev6 1x 76 2.946 RF00005 URS000041AF00_562 37537169 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with amikacin, mRNA, and A-, P-, and E-site tRNAs; P-site tRNA 8ev6 1y 74 2.946 RF00005 URS00005AA258_562 37537169 0030533 0006412 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((......)))).((((.........)))).....(((((.......)))))))))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with amikacin, mRNA, and A-, P-, and E-site tRNAs; A-site and E-site tRNAs 8ev6 2A 2800 2.946 RF02541 URS00001698E8_300852 37537169 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu 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(((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...((((((((.....))))))))....{.(((((((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).))))....(((((((((.[.....)))))))))....}.(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((()))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((.....((..........))......)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((....)))))))).))..........]]].)....))))))))))...)))))))(((((((..)))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(......[..(((((...((.......((((.((....)).))))....))...........].)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(((...)).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with amikacin, mRNA, and A-, P-, and E-site tRNAs; 23S Ribosomal RNA 8ev6 2B 120 2.946 RF00001 URS000080DEE8_300852 37537169 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>. ..(((((((((....((((((.(....(((((((...(.....)...))))..)))...).)))).))(((.......((((((((....)))))))).......))).))))))))).. Crystal structure of the Thermus thermophilus 70S ribosome in complex with amikacin, mRNA, and A-, P-, and E-site tRNAs; 5S Ribosomal RNA 8ev6 2a 1503 2.946 RF00177,RF01959,RF02542,RF01960 URS000080DFED_300852 37537169 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggau .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<......>>....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((.(((((...))))).))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((((((....)))))))....(.(....).)....)))))))).((.((....((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...))..))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.(.((....)).)).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}... Crystal structure of the Thermus thermophilus 70S ribosome in complex with amikacin, mRNA, and A-, P-, and E-site tRNAs; 16S Ribosomal RNA 8ev6 2v 13 2.946 37537169 10665 aaaaauguucuaa ............. ............. Crystal structure of the Thermus thermophilus 70S ribosome in complex with amikacin, mRNA, and A-, P-, and E-site tRNAs; mRNA 8ev6 2w 72 2.946 RF00005 URS00005AA258_562 37537169 0030533 0006412 562 cccgganagcucagggagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<..<<<<.....>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((...[.)))).((((.........))))......((((..]....)))).))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with amikacin, mRNA, and A-, P-, and E-site tRNAs; A-site and E-site tRNAs 8ev6 2x 76 2.946 RF00005 URS000041AF00_562 37537169 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with amikacin, mRNA, and A-, P-, and E-site tRNAs; P-site tRNA 8ev6 2y 73 2.946 RF00005 URS00005AA258_562 37537169 0030533 0006412 562 gcccgganagcucagggagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<.....>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[.)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with amikacin, mRNA, and A-, P-, and E-site tRNAs; A-site and E-site tRNAs 8ev7 1A 2871 2.89 RF02541 URS00001698E8_300852 37537169 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>....<<<<<.....<......>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<....<<<<........>>>..>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..<<......(..>>...>>>.........<<......>>.).>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((...((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((.(..(((.(......).))..))..)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((..((.........))...))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(......[..(((((..(((......((((((((....))))))))...)))..........].)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((...)))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with kanamycin, mRNA, and A-, P-, and E-site tRNAs; 23S Ribosomal RNA 8ev7 1B 120 2.89 RF00001 URS000080DEE8_300852 37537169 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the Thermus thermophilus 70S ribosome in complex with kanamycin, mRNA, and A-, P-, and E-site tRNAs; 5S Ribosomal RNA 8ev7 1a 1500 2.89 RF00177,RF01959,RF02542,RF01960 URS000080DFED_300852 37537169 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>.<..<<......>>.>..>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((((((....))))))).)))))......(((......((((((((..((...(((((((.(((((....(((((......))))).....)))))....((((..((((....))))..))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((.(((....))).)))....(((....)))....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the Thermus thermophilus 70S ribosome in complex with kanamycin, mRNA, and A-, P-, and E-site tRNAs; 16S Ribosomal RNA 8ev7 1v 13 2.89 37537169 10665 aaaaauguucuaa ............. ............. Crystal structure of the Thermus thermophilus 70S ribosome in complex with kanamycin, mRNA, and A-, P-, and E-site tRNAs; mRNA 8ev7 1w 74 2.89 RF00005 URS00005AA258_562 37537169 0030533 0006412 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[..)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with kanamycin, mRNA, and A-, P-, and E-site tRNAs; A-site and E-site tRNAs 8ev7 1x 76 2.89 RF00005 URS000041AF00_562 37537169 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with kanamycin, mRNA, and A-, P-, and E-site tRNAs; P-site tRNA 8ev7 1y 74 2.89 RF00005 URS00005AA258_562 37537169 0030533 0006412 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((......)))).((((.........)))).....(((((.......)))))))))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with kanamycin, mRNA, and A-, P-, and E-site tRNAs; A-site and E-site tRNAs 8ev7 2A 2800 2.89 RF02541 URS00001698E8_300852 37537169 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu 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(((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....(())....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((.(((...(((...(((.((((....(((..........)).)....)))).)))..)).)...))).)))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((.().)))))))).))..........]]].)....))))))))))...)))))))(((((((..)))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........(((((...((......((((((((....))))))))...)).............)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(((...)).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with kanamycin, mRNA, and A-, P-, and E-site tRNAs; 23S Ribosomal RNA 8ev7 2B 120 2.89 RF00001 URS000080DEE8_300852 37537169 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>>. ..(((((((((....((((((.(....(((((((...(.....)...))))..)))...).)))).))(((.......((((((((....)))))))).......))).))))))))).. Crystal structure of the Thermus thermophilus 70S ribosome in complex with kanamycin, mRNA, and A-, P-, and E-site tRNAs; 5S Ribosomal RNA 8ev7 2a 1503 2.89 RF00177,RF01959,RF02542,RF01960 URS000080DFED_300852 37537169 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggau .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<......>>....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((((((....)))))))....(........)....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.(.((....)).)).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}... Crystal structure of the Thermus thermophilus 70S ribosome in complex with kanamycin, mRNA, and A-, P-, and E-site tRNAs; 16S Ribosomal RNA 8ev7 2v 13 2.89 37537169 10665 aaaaauguucuaa ............. ............. Crystal structure of the Thermus thermophilus 70S ribosome in complex with kanamycin, mRNA, and A-, P-, and E-site tRNAs; mRNA 8ev7 2w 72 2.89 RF00005 URS00005AA258_562 37537169 0030533 0006412 562 cccgganagcucagggagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<..<<<<.....>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((...[.)))).((((.........))))......((((..]....)))).))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with kanamycin, mRNA, and A-, P-, and E-site tRNAs; A-site and E-site tRNAs 8ev7 2x 76 2.89 RF00005 URS000041AF00_562 37537169 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the Thermus thermophilus 70S ribosome in complex with kanamycin, mRNA, and A-, P-, and E-site tRNAs; P-site tRNA 8ev7 2y 73 2.89 RF00005 URS00005AA258_562 37537169 0030533 0006412 562 gcccgganagcucagggagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<.....>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[.)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of the Thermus thermophilus 70S ribosome in complex with kanamycin, mRNA, and A-, P-, and E-site tRNAs; A-site and E-site tRNAs 8evp B5 1782 2.38 RF01960,RF02542,RF01959,RF00177 URS0002681484_4932 37595043 0003735 0005840 4932 uaucugguugauccugccaguagucaunugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucnuuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauncaaggnaggcagcaggcgcgcnaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggnacaauuggagggcaagucugnugccagcagccgcggnaauuccagcuccaauagcguauauuaaaguuguugcaguunaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauungcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagancgaaaguuaggggaucgaagaugaucagauacngucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaangcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacncaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuuguggguggngnugcauggcnguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacangucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacnagnaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgnccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuucnguaggugnnccugcggaaggaucauu ...<<<<<.{.((((>>>>><<<<.<<<<<<...<.<...<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<..<<..<<....<<<..................<.....<<.<<.......>>.>>......>.........<<<<<............>>>>><...<<<<<<......(((.{.{.<.<....>.>....<<......>>>>>>>>.....>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>..>>>..>....>.>.....<<<.<<<<.............>.>>>..>>>......<<..<...........>..>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>>>>>.........<<<[[.....<.<<...<<<.<<....<<<<<<.<<<<..............>>>>.>>>>>>.....<..<<...............................>>.>.....<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........<<<..<<<<<<<<.....}..}))).>>>>>>>>.>>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..]]>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..)))).}<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<.<<<<<..>>>>>.>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>......<....<<<<<<..........>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<..<.<<<<.<<<<....>>>>.>>>>.>..>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>........ ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...))[))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((............)))))(.(.((((((......{{..{.{.(.(....).).....(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)....).).....((...(.(...(......)..)..)....))......(.(.(...........))..).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..[......((([[...(.(.((...(((.((....((((((.((..................)).))))))......((((...............................)))).....(((((.((.......((..((.......)).(((.....)))....))......)).))..)))..............(.((.((......}..}.}}..)).)).).........))...(((.(((.((...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)).)))..))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..((((((((.((..........))))))))))..)))...((..]]))...))...].))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((........((.(((........))).))......)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..(((...(((((..((((((..))))))....)))))...))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...(((..(..((((.((.(....).)).))))...).)))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}....... Hypopseudouridylated yeast 80S bound with Taura syndrome virus (TSV) internal ribosome entry site (IRES), Structure I; 18S rRNA 8evp A1 3198 2.38 RF02543 URS0002681478_4932 37595043 0003735 0005840 4932 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugnaacnnggaccaaggagunuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccnanagauggugancuaugccugaauagggugaagccagaggaaacucugguggaggcucguancgguucugncgugcaaaucgaucgucgaaunuggguauagnggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcngaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaunuuggugguagunncaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaanguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauunaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugccnagugcucugaaugucaaagugangaaauucaaccaagcgcggguaaacggcgggaguancuaugacucucuuaagguagcnannugccucnucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugunccuaucuacnaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcungacncuaguuugacauugugaagagacauagaggguguagaauaagugggagcuucggcgccagugaaauaccacuaccuuuauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcugnggcggcacaucugunaaacgnuaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauunucagngugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuanangugccagaaaaguuaccacagngauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuungaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggaunnuucacccacuaauagggaacgugngnuggguuuagancgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..<<<...<.......<<.<<<<<<...>>>>>>.>>.......>.....<<<<<<<.<<<<<<.<<..<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>>....>>>>.....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<......<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<....<.<<<<........>>>>>......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<....<<.<<<<<<<.....<<<....<<<....<<<<...............>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>..>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<.<<<.......<<.........>>...............<<......>>...>>>.>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>.........<<<<..........>>>>.....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<......<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..[[[..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>............>>.>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<....<....>.....>>>>><<.<<<<<<<<<<......>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<..<<<<<<<.<<.<<<.<<<..........<<..........................>>..>>>>>>..>>.>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))......<<<<<<<..<<<<.))))))>>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<<...<<<<<<<<<<]]].>>>>>..>>>>>..>>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<.<..<<<<<......>>>>>..>>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.((((.(.(.(...((((((((...({((((......)))))[[(...).(((....}]])))....))))))))....).).)......))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((.......((..........))........))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((......(((....)))..((((((((((....((.(((((((.....(((....(((..(.(((.................))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(.((....(...((.........))...).......(...((......)).)..)).)...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....))).........((.(..........).)).....))....))...(((((........)))))]]((((..(((((.....((((....))).....<.((((((...((((.((((((((((((((((((...{{..))))))....(((((....(((((.....(((.....))).....))))).....))))).....(((((((......))))))))))).).))))))).))))(...)....))))))....).......)).))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((.(......).))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...((.....(((......))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.(....(..((..........(..(..(.(...))............)..)..))..)....).)))))))....((((.....((((..((((........))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((.(......(....).....).))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Hypopseudouridylated yeast 80S bound with Taura syndrome virus (TSV) internal ribosome entry site (IRES), Structure I; 25S rRNA 8evp A3 121 2.38 RF00001 URS000055688D_4932 37595043 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Hypopseudouridylated yeast 80S bound with Taura syndrome virus (TSV) internal ribosome entry site (IRES), Structure I; 5s rRNA 8evp A4 158 2.38 RF00002 URS00001BF64E_4932 37595043 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Hypopseudouridylated yeast 80S bound with Taura syndrome virus (TSV) internal ribosome entry site (IRES), Structure I; 5.8 S rRNA 8evp EC 192 2.38 URS000268147B_142102 37595043 142102 aaacuccauguauugguuacccaucugcaucgaaaacucuccgaacacggugcaguaaggcuuucauggagugguuugcuauuuagcguacguguaccauaggcagccccaaaaacacgugaggagaaagucccagucacuuugggcaaaguagacagccgcgcuugcguggugggacuuaauuaaugccug ...<<<<<<<..............<<<<<<........((((.......>>>>>>.........>>>>>>>.<<<..<<<....>>>........>>>...<<.....>>............))))..<<<<<<.<<<.....((((......>>>.<<<<<<....>>>>>>>>>>>>........)))). ...((((((...............((((..........[[[[.........))))..........)))))).(((..((......)).....[.[)))...((.....))....].].....]]]]...((((..(((.....[[[[......))).(((.((....)).))).)))).........]]]]. Hypopseudouridylated yeast 80S bound with Taura syndrome virus (TSV) internal ribosome entry site (IRES), Structure I; Internal ribosome entry site 8evq B5 1782 2.72 RF01960,RF02542,RF01959,RF00177 URS0002681484_4932 37595043 0003735 0005840 4932 uaucugguugauccugccaguagucaunugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucnuuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauncaaggnaggcagcaggcgcgcnaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggnacaauuggagggcaagucugnugccagcagccgcggnaauuccagcuccaauagcguauauuaaaguuguugcaguunaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauungcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagancgaaaguuaggggaucgaagaugaucagauacngucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaangcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacncaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuuguggguggngnugcauggcnguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacangucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacnagnaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgnccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuucnguaggugnnccugcggaaggaucauu ...<<<<<.{.((((>>>>><<<<.<<<<<<...<.<...<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<..<.....<<<..<<..<<....<<<..................<.....<<.<<.......>>.>>......>.........<<<<<............>>>>><...<<<<<<......(((.{((.<.<....>.>.....<......>.>>>>>>.....>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>>>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>..>>>..>....>.>.....<<<..<..................>...>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>>.........<<<[[.....<.<<...<<<.<<....<<<<<<.<<<<..............>>>>.>>>>>>......<<<<...............................>>>>.....<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........<<...<<<<<<<<.....)).}))).>>>>>>>>..>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..]]>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..)))).}<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<.<<<<<..>>>>>.>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>......<....<<<<<<..........>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<...<<<<.<<<<....>>>>.>>>>...>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>........ ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((............)))))(.(.((((((......[[[.[[[.(.(....).).....(......).)))))).)...).(.((((...(((..).))..)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.(((......)))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(....(.....(......).....).....)......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.((..................)).))))))......((((.............(.....)...........)))).....(((((.((.......((..((.......)).(((.....)))....))......)).))..)))..............(.((.((......]].]]]]..)).)).).........))...(((.(((.((...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)).)))..))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........((((..(....(((((........((.(((........))).))......)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..(((...(((((..((((((..))))))....)))))...))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....)..))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...(((((.(.((((.((.(....).)).))))..))))))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>....... Hypopseudouridylated Ribosome bound with TSV IRES, eEF2, GDP, and sordarin, Structure I; 18S rRNA 8evq A1 3198 2.72 RF02543 URS0002681478_4932 37595043 0003735 0005840 4932 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugnaacnnggaccaaggagunuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccnanagauggugancuaugccugaauagggugaagccagaggaaacucugguggaggcucguancgguucugncgugcaaaucgaucgucgaaunuggguauagnggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcngaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaunuuggugguagunncaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaanguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauunaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugccnagugcucugaaugucaaagugangaaauucaaccaagcgcggguaaacggcgggaguancuaugacucucuuaagguagcnannugccucnucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugunccuaucuacnaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcungacncuaguuugacauugugaagagacauagaggguguagaauaagugggagcuucggcgccagugaaauaccacuaccuuuauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcugnggcggcacaucugunaaacgnuaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauunucagngugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuanangugccagaaaaguuaccacagngauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuungaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggaunnuucacccacuaauagggaacgugngnuggguuuagancgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>...{.....<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<<.<<<<<<<.<...<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>....>.>>>.....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]....}.............................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<......<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<........>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<<.............>>>>>....>>>..>>.>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<......<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>....>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<..........>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>...<...<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>...>......>.>>.>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<....<....>.....>>>>><<.<<<<<<<<<<......>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<<<<<<.<<<..........<<..........................>>..>>>>>>>.>>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<<...<<<<<<<<<<}}}.>>>>>..>>>>>..>>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.((((.(......(((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..).....)......))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((........(..........).........))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((......(((....)))..((((((((((....((.(((((((.....(((....(((..(.((((...............)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(.(((.(.(...((.........))....)).....(...((......)).).))).)...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....))).........((...((...))....)).....))....))...(((((........)))))]]((((..(((((.(...((((....))).....<.((((((...((((.((((((((((((((((((...{{..))))))....(((((....(((((.....(((.....))).....))))).....))))).....(((((((......))))))))))).).))))))).))))(...)....))))))....).....).)).))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((.(......).))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...((.....(((......))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.((((((..((..........(..(..(......)............)..)..)).)))).)).)))))))....((((.....((((..((((........))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((.(......(....).....).))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Hypopseudouridylated Ribosome bound with TSV IRES, eEF2, GDP, and sordarin, Structure I; 25S rRNA 8evq A3 121 2.72 RF00001 URS000055688D_4932 37595043 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<<............>>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Hypopseudouridylated Ribosome bound with TSV IRES, eEF2, GDP, and sordarin, Structure I; 5s rRNA 8evq A4 158 2.72 RF00002 URS00001BF64E_4932 37595043 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Hypopseudouridylated Ribosome bound with TSV IRES, eEF2, GDP, and sordarin, Structure I; 5.8 S rRNA 8evq EC 200 2.72 URS000268147B_142102 37595043 142102 aaacuccauguauugguuacccaucugcaucgaaaacucuccgaacacuaggugcaguaaggcuuucauggagugguuugcuauuuagcguacguguaccauaggcagccccaaaaacacgugugaggagaaagucccagucacuuugggcaaaguagacagccgcgcuugcguggugggacuuaauuaaugccugcuaa ...<<<<<<<..............<<<<<<.......(((((.........>>>>>>.........>>>>>>><<<...<<......>>.........>>>..<<.....>>..............)))))..<<.<<.<<<<<<<.((((.>>>>.>>>.<<<<<<....>>>>>>.>>>>.........))))..... ...((((((...............((((...........[[[...........))))..........))))))(((...((......)).....[...)))(.((.....)).)....].......]]]....((.(..(((((((.[[[[.)))).)))..((.((....)).))...))).........]]]]..... Hypopseudouridylated Ribosome bound with TSV IRES, eEF2, GDP, and sordarin, Structure I; Taura syndrome virus (TSV) internal ribosome entry site (IRES) RNA 8evr B5 1173 2.87 RF01960,RF02542,RF01959,RF00177 URS0002681484_4932 37595043 0003735 0005840 4932 uaucugguugauccugccaguagucaunugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucnuuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauncaaggnaggcagcaggcgcgcnaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggnacaauuggagggcaagucugnugccagcagccgcggnaauuccagcuccaauagcguauauuaaaguuguugcaguunaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauungcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagancgaaaguuaggggaucgaagaugaucagauacngucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaangcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugac ...<<<<<.{.((((>>>>><<<<.<<<<<<...<.<...<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<..<<..<<....<<<..................<.....<<.<<<.....>>>.>>......>.........<<<<<............>>>>><...<<<<<<......(((.(((.<.<....>.>..............>>>>>>.....>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>..>>>..>....>.>.....<<<<<<..................>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>>.........<<<[[.....<.<<...<<<.<<....<<<<<<.<<<<..............>>>>.>>>>>>......<<<.................................>>>.....<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........<<<..<<<<<<<<.....))).))).>>>>>>>>.>>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..]]>>...>>.....>>>.>>>.<<<......<<<......>>>....>>>..)))).}.............................................. ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((............)))))(.(.((((((......[[[.[[[.(.(....).).....(......).)))))).)...).(.((((...(((..).))..)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(....(.(...(......).)...).....)......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.((..................)).))))))......((((.............(.....)...........)))).....((((..((.......((..((.......)).(((.....)))....))......))..)..)))..............(.((.(((.....]].]]]].))).)).).........))...(((((((.((...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)).))).)))..))))...)).)....((((((....(...((((.........))))...).))))))..........(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].].............................................. Hypopseudouridylated yeast 80S bound with Taura syndrome virus (TSV) internal ribosome entry site (IRES), eEF2, GDP, and sordarin, Structure II; 18S rRNA 8evr A1 3198 2.87 RF02543 URS0002681478_4932 37595043 0003735 0005840 4932 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugnaacnnggaccaaggagunuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccnanagauggugancuaugccugaauagggugaagccagaggaaacucugguggaggcucguancgguucugncgugcaaaucgaucgucgaaunuggguauagnggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcngaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaunuuggugguagunncaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaanguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauunaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugccnagugcucugaaugucaaagugangaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagcnannugccucnucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugunccuaucuacnaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcungacncuaguuugacauugugaagagacauagaggguguagaauaagugggagcuucggcgccagugaaauaccacuaccuuuauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcugnggcggcacaucugunaaacgnuaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauunucagngugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuanangugccagaaaaguuaccacagngauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuungaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggaunnuucacccacuaauagggaacgugngnuggguuuagancgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..<<<..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<.<<<<<<<..<..<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>>...>..>>.....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<<.....<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<........>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<<.............>>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>>..<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>.........<<<<.<.....>..>>>>.....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..[[[..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>.>>.>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<.<<<<<<<<<<......>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<.<..........>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<..<<<<<<<<<<<<<<..<<..........<<<........................>>>..>>.>>>>.>>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))......<<<<<<<..<<<<.))))))>>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<<...<<<<<<<<<<]]].>>>>>..>>>>>..>>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.((((.(.....(...((((((...({((((......)))))[[(...).(((....}]])))....)))))).....)....)......))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((........(..........).........))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((......(((....)))..((((((((((....((.(((((((.....(((....(((..(.((((...............)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(.(((.((....((.........))....)).....(...((......)).).))).)...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....))).........((....(...).....)).....))....))...(((((........)))))]]((((..(((((.....((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))....(((((....(((((.....(((.....))).....))))).....))))).....(((((((......))))))))))).).))))))).))))(...)....))))))...)).......)).))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((.(......).))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...((.....(((......))).....)).)))))..)))))(.................)........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..((((((..((.(((..((..........(..(..(.(...))............)..)..)).)))..))..))))))....((((.....((((..((((........))))...........>....(((((....)))))...))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((.(......(....).....).))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Hypopseudouridylated yeast 80S bound with Taura syndrome virus (TSV) internal ribosome entry site (IRES), eEF2, GDP, and sordarin, Structure II; 25S rRNA 8evr A3 121 2.87 RF00001 URS000055688D_4932 37595043 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<<............>>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Hypopseudouridylated yeast 80S bound with Taura syndrome virus (TSV) internal ribosome entry site (IRES), eEF2, GDP, and sordarin, Structure II; 5s rRNA 8evr A4 158 2.87 RF00002 URS00001BF64E_4932 37595043 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Hypopseudouridylated yeast 80S bound with Taura syndrome virus (TSV) internal ribosome entry site (IRES), eEF2, GDP, and sordarin, Structure II; 5.8 S rRNA 8evr EC 191 2.87 URS000268147B_142102 37595043 142102 aaacuccauguauugguuacccaucugcaucgaaaacucuccgaacacuaggugcaguaaggcuuucauggagugguuugcuauuuagcguacguguaccauaggcagccccaaaaacacgugugaggagaaagucccagucacuuugggcaaaguagacagccgcgcuugcguggugggacuuaauuaau ...<<<<<<<..............<<<<<..........(((..........>>>>>.........>>>>>>><<<...<<......>>.........>>>..<<.....>>..............)))....<..<<.<<<<<<<......>>>>.>>>..<<<<<....>>>>>..>>.>......... ...((((((...............((((...........[[[...........))))..........))))))((....((......)).....[....))..((.....))......].......]]].....(.(..((((((........))).)))..((.((....)).))...)).......... Hypopseudouridylated yeast 80S bound with Taura syndrome virus (TSV) internal ribosome entry site (IRES), eEF2, GDP, and sordarin, Structure II; TSV IRES 8evs B5 1173 2.62 RF01960,RF02542,RF01959,RF00177 URS0002681484_4932 37595043 0003735 0005840 4932 uaucugguugauccugccaguagucaunugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucnuuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauncaaggnaggcagcaggcgcgcnaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggnacaauuggagggcaagucugnugccagcagccgcggnaauuccagcuccaauagcguauauuaaaguuguugcaguunaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauungcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagancgaaaguuaggggaucgaagaugaucagauacngucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaangcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugac ...<<<<<.{.((((>>>>><<<<.<<<<<<...<.<...<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<..<<..<<....<<<..................<.....<<.<<<.....>>>.>>......>.........<<<<<............>>>>><...<<<<<<......(((.{((.<.<....>.>.....<......>.>>>>>>.....>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>..>>>..>....>.>.....<<.<<<..................>>>..>>......<<..<...........>..>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>>>>>.........<<<[[.....<.<<...<<<.<<....<<<<<<.<<<................>>>.>>>>>>......<<<.................................>>>.....<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........<<...<<<<<<<<.....)).}))).>>>>>>>>..>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..]]>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..)))).}.............................................. ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((............)))))(.(.((((((......[[[.[[[.(.(....).).....(......).)))))).)...).(.((((...(((..).))..)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(....(.....(......).....).....)......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.((..................)).))))))......((((.............(.....)...........)))).....(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(....(.((.(((.....]].]]]].))).)).)...).....))...(((.(((.((...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)).)))..))..))))...)).)....((((((....(...((((.........))))...).))))))..........(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].].............................................. Hypopseudouridylated yeast 80S bound with Taura syndrome virus (TSV) internal ribosome entry site (IRES), eEF2 and GDP, Structure II; 18S rRNA 8evs A1 3198 2.62 RF02543 URS0002681472_4932 37595043 0003735 0005840 4932 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugnaacnnggaccaaggagunuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccnanagauggugancuaugccugaauagggugaagccagaggaaacucugguggaggcucguancgguucugncgugcaaaucgaucgucgaaunuggguauagnggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcngaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaunuuggugguagunncaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaanguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauunaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugccnagugcucugaaugucaaagugangaaauucaaccaagcgcggguaaacggcgggaguancuaugacucucuuaagguagcnannugccucnucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugunccuaucuacnaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcungacncuaguuugacauugugaagagacauagaggguguagaauaagugggagcuucggcgccagugaaauaccacuaccuuuauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcugnggcggcacaucugunaaacgnuaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauunucagngugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuanangugccagaaaaguuaccacagngauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuungaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggaunnuucacccacuaauagggaacgugngnuggguuuagancgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..<<<..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<<.<<<<<<<.<..<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>>...>.>>>.....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<......<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<.......<<<........>>>........>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<<.............>>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>>..<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>.........<<<<..........>>>>.....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<......<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..[[[..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>............>>.>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<.<<<<<<<<<<......>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<..<<<.....<<<<....>>>>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<..<<<<<<<<<<<<<<<<<............<..........................>...>>>>>>>.>>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))......<<<<<<<..<<<<.))))))>>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<<...<<<<<<<<<<]]].>>>>>..>>>>>..>>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<.<..<<<<<......>>>>>..>>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((..(((.(.(.(...((((((((...({((((......)))))[[(...).(((....}]])))....))))))))....).).)......))).))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((.......((..........))........))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((......(((....)))..((((((((((....((.(((((((.....(((....(((..(.((((...............)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(.(((.((....((.........))....)).....(...((......)).).))).)...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....))).........((((.((...))..)))).....))....))...(((((........)))))]]((((..(((((.(...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))....(((((....(((((.....(((.....))).....))))).....))))).....(((((((......))))))))))).).))))))).))))(...)....))))))...)).....).)).))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((.(......).))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...((.....(((......))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.((.((.(.((..........(..(..(......)............)..)..))).))..)).)))))))....((((.....((((..((((........))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((.(......(....).....).))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Hypopseudouridylated yeast 80S bound with Taura syndrome virus (TSV) internal ribosome entry site (IRES), eEF2 and GDP, Structure II; 25S rRNA 8evs A3 121 2.62 RF00001 URS000055688D_4932 37595043 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<<............>>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Hypopseudouridylated yeast 80S bound with Taura syndrome virus (TSV) internal ribosome entry site (IRES), eEF2 and GDP, Structure II; 5s rRNA 8evs A4 158 2.62 RF00002 URS00001BF64E_4932 37595043 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Hypopseudouridylated yeast 80S bound with Taura syndrome virus (TSV) internal ribosome entry site (IRES), eEF2 and GDP, Structure II; 5.8 S rRNA 8evs EC 195 2.62 URS000268147B_4932 37595043 4932 aaacuccauguauugguuacccaucugcaucgaaaacucuccgaacacuaggugcaguaaggcuuucauggagugguuugcuauuuagcguacguguaccauaggcagccccaaaaacacgugugaggagaaagucccagucacuuugggcaaaguagacagccgcgcuugcguggugggacuuaauuaaugccu ...<<<<<<<..............<<<<<........(((((..........>>>>>.........>>>>>>><<<<..<<<....>>>........>>>>..<<.....>>..............)))))..<..<<.<<<<<<<.((((.>>>>.>>>..<<<<<....>>>>>..>>.>.........)))) ...((((((...............((((..........[[[[...........))))..........))))))((....(((....))).....[....))..((.....))......].......]]]]....(.(..((((((..[[[[..))).)))..((.((....)).))...))..........]]]] Hypopseudouridylated yeast 80S bound with Taura syndrome virus (TSV) internal ribosome entry site (IRES), eEF2 and GDP, Structure II; TSV IRES 8evt B5 1173 2.2 RF01960,RF02542,RF01959,RF00177 URS0002681484_4932 37595043 0003735 0005840 4932 uaucugguugauccugccaguagucaunugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucnuuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauncaaggnaggcagcaggcgcgcnaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggnacaauuggagggcaagucugnugccagcagccgcggnaauuccagcuccaauagcguauauuaaaguuguugcaguunaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauungcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagancgaaaguuaggggaucgaagaugaucagauacngucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaangcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugac ...<<<<<.{.((((>>>>><<<<.<<<<<<...<.<...<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<..<<..<<....<<<..................<.....<<.<<<.....>>>.>>......>.........<<<<<............>>>>><...<<<<<<.......((.{.................<<......>>>>>>>>.....>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>..>>>..>....>.>.....<<<.<<<................>>>..>>>......<<..<...........>..>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>>>>>.........<<<[[.....<.<<...<<<.<<....<<<<<<.<<<<..............>>>>.>>>>>>......<<<<...............................>>>>.....<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........<<<..<<<<<<<<........}))..>>>>>>>>.>>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..]]>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..)))).}.............................................. ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((.....(..........)....))[))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((............)))))(.(.((((((........{....................(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)....).).....((...(.(...(......).)...)....))......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..[......((([[...(.(.((...(((.((....((((((.((.(..............).)).))))))......((((...............................)))).....(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(....(.((.(((..........}..))).)).)...).....))...(((.(((.((...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)).)))..))..))))...)).)....((((((....(...((((.........))))...).))))))..........(((.((.(((..((((((((.(((........)))))))))))..)))...((..]]))...))...].))))))).(((......((((....))))....)))...]]].].............................................. Hypopseudouridylated yeast 80S bound with Taura syndrome virus (TSV) internal ribosome entry site (IRES) refined against a composite map; 18S rRNA 8evt A1 3192 2.2 RF02543 URS0002681478_4932 37595043 0003735 0005840 4932 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugnaacnnggaccaaggagunuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccnanagauggugancuaugccugaauagggugaagccagaggaaacucugguggaggcucguancgguucugncgugcaaaucgaucgucgaaunuggguauagnggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcngaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaunuuggugguagunncaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaanguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauunaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugccnagugcucugaaugucaaagugangaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagcnannugccucnucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugunccuaucuacnaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcungacncuaguuugacauugugaagagacauagaggguguagaauaagugggagcuucggcgccagugaaauaccacuaccuuuauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcugnggcggcacaucugunaaacgnuaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauunucagngugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuanangugccagaaaaguuaccacagngauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuungaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggaunnuucacccacuaauagggaacgugngnuggguuuagancgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu .........................<<<<<.....<<....>>......>>>>>...........<<....>>..<<<<<......<<.....>>.....>>>>>..<<<...<.......<<.<<<<<<...>>>>>>.>>.......>.....<<<<<<<.<<<<<<<.<..<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>>...>.>>>.....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<......<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<........>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<...<<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>>.<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<.................>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<......<..........<<<.<<<<<<<<<<.........<<<.............................<........>...>>>.....>>>>>>>>>>>>>..........))).>....>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>>..<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<..........>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<......<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..[[[..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>............>>.>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<...............>>>>><<.<<<<<<<<<<......>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<.........>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<..<<<<.<<<<<...<<<.<..........<<<........................>>>..>>>.>...>>>>>.>>>>...<<<<<.....<<<<..<<<<........>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))......<<<<<<<..<<<<.))))))>>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<....<<<<<<<<<<]]].>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<.<..<<<<<......>>>>>..>>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.((((.((..(...((((((((...({((((......)))))[[(...).(((....}]])))....))))))))....)..))......))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((.......(((........)))........))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((......(((....)))..((((((((((....((.(((((((.....(((....(((..(.(((.................))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(.(((........(.........)......(...(........).).))).)...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....))).........((..............)).....))....))...(((((........)))))]]((((..(((((.....((((....))).....<.((((((...((((.((((((((((((((((((...{{..))))))....(((((....(((((.....(((.....))).....))))).....))))).....(((((((......))))))))))).).))))))).))))(...)....))))))....).......)).))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((.(......).))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.....((.....(((......))).....))..))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..((((.((.((....(.((..........(..(..(......)............)..)..))).....)).)).))))....((((.....((((..((((........))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((.(......(....).....).))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Hypopseudouridylated yeast 80S bound with Taura syndrome virus (TSV) internal ribosome entry site (IRES) refined against a composite map; 25S rRNA 8evt A3 121 2.2 RF00001 URS000055688D_4932 37595043 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Hypopseudouridylated yeast 80S bound with Taura syndrome virus (TSV) internal ribosome entry site (IRES) refined against a composite map; 5s rRNA 8evt A4 158 2.2 RF00002 URS00001BF64E_4932 37595043 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Hypopseudouridylated yeast 80S bound with Taura syndrome virus (TSV) internal ribosome entry site (IRES) refined against a composite map; 5.8 S rRNA 8evt EC 57 2.2 URS000268147B_4932 37595043 4932 gguuugcuauuuagcguacguguaccauaggcagccccaaaaacacguaaugccugc <<<..<<<....>>>.....((.>>>...<<.....>>.....))............ (.(..((......))........).)....(.....).................... Hypopseudouridylated yeast 80S bound with Taura syndrome virus (TSV) internal ribosome entry site (IRES) refined against a composite map; TSV IRES 8ewb B5 1782 2.87 RF01960,RF02542,RF01959,RF00177 URS0002681483_4932 37595043 0003735 0005840 4932 uaucugguugauccugccaguagucaunugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucnuuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauncaaggnaggcagcaggcgcgcnaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggnacaauuggagggcaagucugnugccagcagccgcggnaauuccagcuccaauagcguauauuaaaguuguugcaguunaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauungcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagancgaaaguuaggggaucgaagaugaucagauacngucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaangcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacncaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuuguggguggngnugcauggcnguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacangucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacnagnaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgnccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuucnguaggugnnccugcggaaggaucauu ...<<<<<.{.((((>>>>><<<<.<<<<<<...<.<...<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<..<<..<<....<<<..................<.....<<.<<<.....>>>.>>......>.........<<<<<............>>>>><...<<<<<<......(((.{((...<....>................>>>>>>.....>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>..>>>..>....>.>.....<<..<<<................>>>...>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>>.........<<<[[.....<.<<...<<<.<<....<<<<<<.<<<<..............>>>>.>>>>>>......<<<.................................>>>.....<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........<<<..<<<<<<<<.....)).}))).>>>>>>>>.>>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..]]>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..)))).}<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<.......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<...<<<<<..>>>>>.....>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>>....>.>>>>>....>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>......<....<<<<<<..........>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<...<<<<.<<<<....>>>>.>>>>...>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>........ ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((............)))))(.(.((((((......[[[.[.[.(((....))).....(......).)))))).)...).(.((((...(((..).))..)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(....(.....(......).....).....)......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.((..................)).))))))......((((.............(.....)...........)))).....(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(....(.((.(((.....]..]]]].))).)).)...).....))...(((..((.((...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)).))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........((((..(....(((((........((.(((........))).))......)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..(((...(((((..(.((((..)))).)....)))))...))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....)..))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...((((..(.((((.((((....)))).))))..).))))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>....... Hypopseudouridylated yeast 80S bound with Taura syndrome virus (TSV) internal ribosome entry site (IRES), eEF2 and GDP, Structure III; 18S rRNA 8ewb A1 3198 2.87 RF02543 URS0002681478_4932 37595043 0003735 0005840 4932 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugnaacnnggaccaaggagunuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccnanagauggugancuaugccugaauagggugaagccagaggaaacucugguggaggcucguancgguucugncgugcaaaucgaucgucgaaunuggguauagnggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcngaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaunuuggugguagunncaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaanguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauunaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugccnagugcucugaaugucaaagugangaaauucaaccaagcgcggguaaacggcgggaguancuaugacucucuuaagguagcnannugccucnucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugunccuaucuacnaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcungacncuaguuugacauugugaagagacauagaggguguagaauaagugggagcuucggcgccagugaaauaccacuaccuuuauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcugnggcggcacaucugunaaacgnuaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauunucagngugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuanangugccagaaaaguuaccacagngauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuungaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggaunnuucacccacuaauagggaacgugngnuggguuuagancgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>...<.....<<....>>..<<<<<......<<.....>>.....>>>>>..<<<...<.......<<.<<<<<<...>>>>>>.>>.......>.....<<<<<<.<<<<<<<<.<..<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>>...>.>>>.....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>....>.............................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<......<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<........>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<..<.<<<<<.............>>>>>.>..>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>>..<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<......<<<....>>>...<...<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..[[[..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>...>........>>.>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<.<<<<<<<<<<......>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<..<<<<<<<<<<<<<<.<............<<<<....<...>.............>>>>....>>>>>.>>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))......<<<<<<<..<<<<.))))))>>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<....<<<<<<<<<<]]].>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<.<..<<<<<......>>>>>..>>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.((((.(.(.(...((((((((...({((((......)))))[[(...).(((....}]])))....))))))))....).).)......))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((......((((........)))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((......(((....)))..((((((((((....((.(((((((.....(((....(((..(.((((...............)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(.(((.(((...((.........))...))).....(...((......)).).))).)...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....))).........((.(.((...))..).)).....))....))...(((((........)))))]]((((..(((((.....((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))....(((((....(((((.....(((.....))).....))))).....))))).....(((((((......))))))))))).).))))))).))))(...)....))))))...)).......)).))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((.(......).))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...((.....(((......))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..((((((((((...(((............(..(..(......)............)..)....)))...))))))))))....((((.....((((..((((........))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((.(......(....).....).))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...((.((.(..(((......)))..).)).)).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Hypopseudouridylated yeast 80S bound with Taura syndrome virus (TSV) internal ribosome entry site (IRES), eEF2 and GDP, Structure III; 25S rRNA 8ewb A3 121 2.87 RF00001 URS000055688D_4932 37595043 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Hypopseudouridylated yeast 80S bound with Taura syndrome virus (TSV) internal ribosome entry site (IRES), eEF2 and GDP, Structure III; 5s rRNA 8ewb A4 158 2.87 RF00002 URS00001BF64E_4932 37595043 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Hypopseudouridylated yeast 80S bound with Taura syndrome virus (TSV) internal ribosome entry site (IRES), eEF2 and GDP, Structure III; 5.8 S rRNA 8ewb EC 153 2.87 URS000268147A_142102 37595043 142102 aaacuccauguauugguuacccaucugcaucgaaaacucuccgaacacggugcaguaaggcuuucauggagugguuacguguaaggagaaagucccagucacuuugggcaaaguagacagccgcgcuugcguggugggacuuaauuaaugccu ...<<<<<<<..............<<<<<<........((((.......>>>>>>.........>>>>>>>.............)))).........<<<<<<<.((((.>>>>.>>>..<<<<<....>>>>>...............)))) ...(((((................((((..........[[[[.........))))...........)))))...(.......).]]]].........(((((((.[[[[.)))).)))..((.((....)).))...............]]]] Hypopseudouridylated yeast 80S bound with Taura syndrome virus (TSV) internal ribosome entry site (IRES), eEF2 and GDP, Structure III; Taura syndrome virus (TSV) internal ribosome entry site (IRES) RNA 8ewc B5 1782 2.45 RF01960,RF02542,RF01959,RF00177 URS0002681484_4932 37595043 0003735 0005840 4932 uaucugguugauccugccaguagucaunugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucnuuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauncaaggnaggcagcaggcgcgcnaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggnacaauuggagggcaagucugnugccagcagccgcggnaauuccagcuccaauagcguauauuaaaguuguugcaguunaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauungcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagancgaaaguuaggggaucgaagaugaucagauacngucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaangcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacncaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuuguggguggngnugcauggcnguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacangucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacnagnaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgnccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuucnguaggugnnccugcggaaggaucauu ...<<<<<.{.((((>>>>><<<<.<<<<<<...<.<...<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<..<<..<<....<<<..................<.....<<.<<.......>>.>>......>.........<<<<<............>>>>><...<<<<<<......(((.{((.<<<....>>>..............>>>>>>.....>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>..>>>..>....>.>.....<<<.........................>>>......<<..<...........>..>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>>>>>.........<<<[[.....<.<<...<<<.<<....<<<<<<.<<<<..............>>>>.>>>>>>......<<<<.........<...........>.........>>>>.....<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........<<...<<<<<<<<.....)).}))).>>>>>>>>..>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..]]>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..)))).}<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<......<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<.<<<<<..>>>>>.>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>.......>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<.<<.<<<<.<<<<....>>>>.>>>>..>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>........ ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..................(.....((.(((.....))).))......).........(((((............)))))(.(.((((((......[[[.[[[.(.(....).).....(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....((...(.....(......).....)....))......(.(.(...........))..).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.((..................)).))))))......(.((.........(...........).........)).).....(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(....(.((.((......]].]]]]..)).)).)...).....))...(((.(((.((...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)).)))..))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........((((..(....(((((........((.(((........))).))......)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..(((...(((((..(((((....)))))....)))))...))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....)..))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...((......((((.((.(....).)).))))......))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>....... Hypopseudouridylated yeast 80S bound with Taura syndrome virus (TSV) internal ribosome entry site (IRES), Structure II; 18S rRNA 8ewc A1 3198 2.45 RF02543 URS0002681478_4932 37595043 0003735 0005840 4932 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugnaacnnggaccaaggagunuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccnanagauggugancuaugccugaauagggugaagccagaggaaacucugguggaggcucguancgguucugncgugcaaaucgaucgucgaaunuggguauagnggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcngaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaunuuggugguagunncaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaanguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauunaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugccnagugcucugaaugucaaagugangaaauucaaccaagcgcggguaaacggcgggaguancuaugacucucuuaagguagcnannugccucnucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugunccuaucuacnaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcungacncuaguuugacauugugaagagacauagaggguguagaauaagugggagcuucggcgccagugaaauaccacuaccuuuauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcugnggcggcacaucugunaaacgnuaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauunucagngugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuanangugccagaaaaguuaccacagngauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuungaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggaunnuucacccacuaauagggaacgugngnuggguuuagancgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..<<<..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<.<<<<<<<<.<..<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>>...>.>>>.....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<......<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<........>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<.<..............>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<.<<<.<<<...<<.........>>...>>>.........<<......>>...>>>.>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<............>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<......<<<....>>>...<...<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..[[[..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<<....>>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>...>........>>.>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<.<<<<<<<<<<......>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<..<<<<<<<<<<.<<<<<............<<..........................>>...>>>>>..>>>>>>>>>>...<<<<<.....<<<<..<<<<........>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))......<<<<<<<..<<<<.))))))>>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<<...<<<<<<<<<<]]].>>>>>..>>>>>..>>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<.<..<<<<<......>>>>>..>>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.((((.(.(.(...((((((((...({((((......)))))[[(...).(((....}]])))....))))))))....).).)......))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((........(..........).........))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((......(((....)))..((((((((((....((.(((((((.....(((....(((..(.(((.................))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(.(((.(((...((.........))...))).....(...((......)).).))).)...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...((((((...((.....)).))))))....[[(((.((...((....(((....)))........((.(..((...))....)))....))....))...(((((........)))))]]((((..(((((.....((((....))).....<.((((((...((((.((((((((((((((((((...{{..))))))....(((((....(((((.....(((.....))).....))))).....))))).....(((((((......))))))))))).).))))))).))))(...)....))))))....).......)).))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((.(......).))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.....((.....(((......))).....))..))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.((...(.(............(..(..(......)............)..)....).)...)).)))))))....((((.....((((..((((........))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((.(......(....).....).))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(((.((..)..).)))..)))))...)))....)))).)))))).))))).. Hypopseudouridylated yeast 80S bound with Taura syndrome virus (TSV) internal ribosome entry site (IRES), Structure II; 25S rRNA 8ewc A3 121 2.45 RF00001 URS000055688D_4932 37595043 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Hypopseudouridylated yeast 80S bound with Taura syndrome virus (TSV) internal ribosome entry site (IRES), Structure II; 5s rRNA 8ewc A4 158 2.45 RF00002 URS00001BF64E_4932 37595043 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Hypopseudouridylated yeast 80S bound with Taura syndrome virus (TSV) internal ribosome entry site (IRES), Structure II; 5.8 S rRNA 8ewc EC 192 2.45 URS000268147B_142102 37595043 142102 aaacuccauguauugguuacccaucugcaucgaaaacucuccgaacacggugcaguaaggcuuucauggagugguuugcuauuuagcguacguguaccauaggcagccccaaaaacacgugaggagaaagucccagucacuuugggcaaaguagacagccgcgcuugcguggugggacuuaauuaaugccug ...<<<<<<...............<<<<<<........((((.......>>>>>>..........>>>>>>.<<<..<<<....>>>........>>>........................))))..<<<<<<.<<<.....((((......>>>.<<<<<<....>>>>>>>>>>>>........)))). ...((((((...............(((((.........[[[[........)))))..........)))))).(((..((......)).....[.[)))...(.......)....].].....]]]]...((((..(((.....[[[[......))).(((.((....)).))).)))).........]]]]. Hypopseudouridylated yeast 80S bound with Taura syndrome virus (TSV) internal ribosome entry site (IRES), Structure II; internal ribosome entry site (IRES) 8eyu B 45 1.95 URS000268140F_32630 37221204 32630 gcgccgggcagaggugggugguguggaggaguaucuguccggcgc <<<<<<<<<<<<.....................>>>>>>>>>>>> ((((((((((((.........(..........))))))))))))) Structure of Beetroot dimer bound to DFAME; RNA (49-MER) 8eyu A 49 1.95 URS000268140F_32630 37221204 32630 gcgccgguuaggcagaggugggugguguggaggaguaucuguccggcgc <<<<<<.....<<<<<.....................>>>>>.>>>>>> (((((((....(((((.........(..........))))))))))))) Structure of Beetroot dimer bound to DFAME; RNA (49-MER) 8eyv A 45 2.55 URS000268140F_32630 37221204 32630 gcgccgggcagaggugggugguguggaggaguaucuguccggcgc <<<<<<<<<<<<.....................>>>>>>>>>>>> ((((((((((((.........(..........))))))))))))) Structure of Beetroot dimer bound to DFHO; RNA (45-MER) 8eyv B 45 2.55 URS000268140F_32630 37221204 32630 gcgccgggcagaggugggugguguggaggaguaucuguccggcgc <<<<<<<<<<<<.....................>>>>>>>>>>>> ((((((((((((.........(..........))))))))))))) Structure of Beetroot dimer bound to DFHO; RNA (45-MER) 8eyw B 49 2.1 URS000268140F_32630 37221204 32630 gcgccgguuaggcagaggugggugguguggaggaguaucuguccggcgc <<<<<<....<<<<<<.....................>>>>>>>>>>>> ((((((....((((((.........(..........))))))))))))) Beetroot dimer bound to ThT; RNA (49-MER) 8eyw A 45 2.1 URS000268140F_32630 37221204 32630 gcgccgggcagaggugggugguguggaggaguaucuguccggcgc <<<<<<<<<<<<.....................>>>>>>>>>>>> (.((((((((((.........(..........))))))))))).) Beetroot dimer bound to ThT; RNA (49-MER) 8f0n B 49 2.85 URS0002681412_32630 37221204 32630 gcgccgguuaggcaguggugggugguguggaggaguagcuguccggcgc <<<<<<....<<<<<<.....................>>>>>>>>>>>> ((((((....((((((.........(..........))))))))))))) Wobble Beetroot (A16U-U38G) dimer bound to DFHO; RNA (49-MER) 8f0n A 49 2.85 URS0002681412_32630 37221204 32630 gcgccgguuaggcaguggugggugguguggaggaguagcuguccggcgc <<<<<<<....<<<<<.....................>>>>>>>>>>>> (((((((....(((((.........(..........))))))))))))) Wobble Beetroot (A16U-U38G) dimer bound to DFHO; RNA (49-MER) 8fc1 1A 2872 2.5 RF02541 URS00001698E8_300852 37452045 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<..<<<...................>>>.........<<......>>....>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<......>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((..(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((.(.((((((......)))).)))..)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((...(...........)...))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((.((((((.(......[..(((((..(((......(((((((......)))))))...)))..........].)))))).)))))).)))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..((((.))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, hygromycin A, and erythromycin at 2.50A resolution; 23S Ribosomal RNA 8fc1 1B 120 2.5 RF00001 URS000080DEE8_300852 37452045 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, hygromycin A, and erythromycin at 2.50A resolution; 5S Ribosomal RNA 8fc1 1a 1500 2.5 RF00177,RF01959,RF02542,RF01960 URS000080DFED_300852 37452045 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<..........>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((.(((..))).)))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((...(((((((....)))))))...((((....))))...)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, hygromycin A, and erythromycin at 2.50A resolution; 16S Ribosomal RNA 8fc1 2A 2867 2.5 RF02541 URS00001698E8_300852 37452045 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<.<.<<<<<<......>>>>.>>>..>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<...<.........>....>>>......................>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<..>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<.......<<<<<<......>>>>>>....>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((..))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((...((.(((......)))..))...)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((........((((.((...(((.......)))....)).........(........)...))))....)))))))))).))..........]]].)....))))))))))...)))))))(((((((())))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((..(.(.((((.(......[..(((((..(((.......((((.((....)).))))....)))..........].)))))).)))).).)..))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))((((.))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, hygromycin A, and erythromycin at 2.50A resolution; 23S Ribosomal RNA 8fc1 2B 120 2.5 RF00001 URS000080DEE8_300852 37452045 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, hygromycin A, and erythromycin at 2.50A resolution; 5S Ribosomal RNA 8fc1 2a 1504 2.5 RF00177,RF01959,RF02542,RF01960 URS000080DFED_300852 37452045 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>.....<......>....>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((...(((((((....))))))).(...((....))...).)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, hygromycin A, and erythromycin at 2.50A resolution; 16S Ribosomal RNA 8fc2 1A 2872 2.5 RF02541 URS00001698E8_300852 37452045 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<..<<<...<<.........>>...>>>.........<<......>>....>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<......>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((..(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....((((((((..[......))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...((((((((.(.((((((......)))).)))..))))))))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((.((((((.(.........(((((..(((......(((((.((....)).)))))...)))............)))))).)))))).)))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..((((.))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, hygromycin A, and azithromycin at 2.50A resolution; 23S Ribosomal RNA 8fc2 1B 120 2.5 RF00001 URS000080DEE8_300852 37452045 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>. .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, hygromycin A, and azithromycin at 2.50A resolution; 5S Ribosomal RNA 8fc2 1a 1500 2.5 RF00177,RF01959,RF02542,RF01960 URS000080DFED_300852 37452045 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<..[.>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>.......]..<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<..........>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((..)))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((...(((((((....)))))))...((((....))))...)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, hygromycin A, and azithromycin at 2.50A resolution; 16S Ribosomal RNA 8fc2 2A 2867 2.5 RF02541 URS00001698E8_300852 37452045 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu .<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<.......>>>....>>......................>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<..>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<.......<<<<<<......>>>>>>....>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>. .((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((..))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...((((((((...((.(((......)))..))...))))))))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((........((((.((...(((.......)))....)).........(........)...))))....)))))))))).))..........]]].)....))))))))))...)))))))(((((((())))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((.(.((((((.(......[..(((((..(((.......((((.((....)).))))....)))..........].)))))).)))))).).)))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(((...)).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...))). Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, hygromycin A, and azithromycin at 2.50A resolution; 23S Ribosomal RNA 8fc2 2B 120 2.5 RF00001 URS000080DEE8_300852 37452045 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, hygromycin A, and azithromycin at 2.50A resolution; 5S Ribosomal RNA 8fc2 2a 1504 2.5 RF00177,RF01959,RF02542,RF01960 URS000080DFED_300852 37452045 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<....<<<......>>>.......>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>.....<......>....>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((...(((((((....))))))).(...((....))...).)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, hygromycin A, and azithromycin at 2.50A resolution; 16S Ribosomal RNA 8fc3 1A 2872 2.6 RF02541 URS00001698E8_300852 37452045 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<......>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((..(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((.(.((((((......)))).)))..)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((.((((((.(.........(((((..(((......((((((........))))))...)))............)))))).)))))).)))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((.))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, hygromycin A, and telithromycin at 2.60A resolution; 23S Ribosomal RNA 8fc3 1B 120 2.6 RF00001 URS000080DEE8_300852 37452045 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>. .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, hygromycin A, and telithromycin at 2.60A resolution; 5S Ribosomal RNA 8fc3 1a 1500 2.6 RF00177,RF01959,RF02542,RF01960 URS000080DFED_300852 37452045 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<..........>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((.(((..))).)))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((((..(((((((....)))))))....(((....)))...))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, hygromycin A, and telithromycin at 2.60A resolution; 16S Ribosomal RNA 8fc3 2A 2867 2.6 RF02541 URS00001698E8_300852 37452045 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<....................>>......................>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<.<<<<<......>>>>>>....>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((..))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...((((((((...((.(((......)))..))...))))))))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((........((((.((....((.......)).....))......................))))....)))))))))).))..........]]].)....))))))))))...)))))))(((((((())))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((.((.((((((.(......[..(((((..(((.......((((.(......).))))....)))..........].)))))).)))))).)).))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))((((.))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, hygromycin A, and telithromycin at 2.60A resolution; 23S Ribosomal RNA 8fc3 2B 120 2.6 RF00001 URS000080DEE8_300852 37452045 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, hygromycin A, and telithromycin at 2.60A resolution; 5S Ribosomal RNA 8fc3 2a 1504 2.6 RF00177,RF01959,RF02542,RF01960 URS000080DFED_300852 37452045 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>.....<......>....>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((...(((((((....))))))).(...((....))...).)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, hygromycin A, and telithromycin at 2.60A resolution; 16S Ribosomal RNA 8fc4 1A 2872 2.45 RF02541 URS00001698E8_300852 37452045 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacganaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<...<...........>...>>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<.......<<<<<<<......>>>>>>>....>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((...((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...((((((((.(.((((((......)))).)))..))))))))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((.((((((.(.........(((((..(((......((((((((....))))))))...)))............)))))).)))))).)))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..((((.))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the A2058-N6-dimethylated Thermus thermophilus 70S ribosome in complex with protein Y, hygromycin A, and erythromycin at 2.45A resolution; 23S Ribosomal RNA 8fc4 1B 120 2.45 RF00001 URS000080DEE8_300852 37452045 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the A2058-N6-dimethylated Thermus thermophilus 70S ribosome in complex with protein Y, hygromycin A, and erythromycin at 2.45A resolution; 5S Ribosomal RNA 8fc4 1a 1500 2.45 RF00177,RF01959,RF02542,RF01960 URS000080DFED_300852 37452045 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<.<......>.>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((..)))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((...(((.(((....))).)))...((((....))))...)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the A2058-N6-dimethylated Thermus thermophilus 70S ribosome in complex with protein Y, hygromycin A, and erythromycin at 2.45A resolution; 16S Ribosomal RNA 8fc4 2A 2867 2.45 RF02541 URS00001698E8_300852 37452045 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacganaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..................>>>......................>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<..>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<.......<<<<<<......>>>>>>....>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...((((((((.....))))))))....{.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).))))....(((((((((.[.....)))))))))....}.(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((..))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((.(.((.(((......)))..)))..)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.........(((.((...(((.......)))....)).........(........)...))).....)))))))))).))..........]]].)....))))))))))...)))))))(((((((..)))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((.((((((.(.........(((((..(((.......((((.((....)).))))....)))............)))))).)))))).)))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))((((.))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal structure of the A2058-N6-dimethylated Thermus thermophilus 70S ribosome in complex with protein Y, hygromycin A, and erythromycin at 2.45A resolution; 23S Ribosomal RNA 8fc4 2B 120 2.45 RF00001 URS000080DEE8_300852 37452045 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> (((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).))))))))))) Crystal structure of the A2058-N6-dimethylated Thermus thermophilus 70S ribosome in complex with protein Y, hygromycin A, and erythromycin at 2.45A resolution; 5S Ribosomal RNA 8fc4 2a 1504 2.45 RF00177,RF01959,RF02542,RF01960 URS000080DFED_300852 37452045 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>.....<......>....>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((.(.((((((((((......((((((.....))))))....))))))))..))).)))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........((((((...(...(((((((...(((((((....))))))).(...((....))...).)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).))))).....))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the A2058-N6-dimethylated Thermus thermophilus 70S ribosome in complex with protein Y, hygromycin A, and erythromycin at 2.45A resolution; 16S Ribosomal RNA 8fc5 1A 2872 2.65 RF02541 URS00001698E8_300852 37452045 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacganaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<......>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((..(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...((((((((.(.((((((......)))).)))..))))))))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((.((((((.(......[..(((((..(((......((((((((....))))))))...)))..........].)))))).)))))).)))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..((((.))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the A2058-N6-dimethylated Thermus thermophilus 70S ribosome in complex with protein Y, hygromycin A, and azithromycin at 2.65A resolution; 23S Ribosomal RNA 8fc5 1B 120 2.65 RF00001 URS000080DEE8_300852 37452045 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>. .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the A2058-N6-dimethylated Thermus thermophilus 70S ribosome in complex with protein Y, hygromycin A, and azithromycin at 2.65A resolution; 5S Ribosomal RNA 8fc5 1a 1500 2.65 RF00177,RF01959,RF02542,RF01960 URS000080DFED_300852 37452045 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<..........>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((..)))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((...(((((((....)))))))...((((....))))...)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the A2058-N6-dimethylated Thermus thermophilus 70S ribosome in complex with protein Y, hygromycin A, and azithromycin at 2.65A resolution; 16S Ribosomal RNA 8fc5 2A 2867 2.65 RF02541 URS00001698E8_300852 37452045 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacganaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<....................>>......................>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<..>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<.......<<<<<<......>>>>>>....>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<.<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>..>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((..))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((...((.(((......)))..))...)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((.(.........(((.((...(((.......)))....)).........(........)...))).....).)))))))).))..........]]].)....))))))))))...)))))))(((((((())))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((..(.((((((.(.........(((((..((........((((.(......).)))).....))............)))))).)))))).)..))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(............(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal structure of the A2058-N6-dimethylated Thermus thermophilus 70S ribosome in complex with protein Y, hygromycin A, and azithromycin at 2.65A resolution; 23S Ribosomal RNA 8fc5 2B 120 2.65 RF00001 URS000080DEE8_300852 37452045 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the A2058-N6-dimethylated Thermus thermophilus 70S ribosome in complex with protein Y, hygromycin A, and azithromycin at 2.65A resolution; 5S Ribosomal RNA 8fc5 2a 1504 2.65 RF00177,RF01959,RF02542,RF01960 URS000080DFED_300852 37452045 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>.....<......>....>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((...(((((((....))))))).(...((....))...).)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the A2058-N6-dimethylated Thermus thermophilus 70S ribosome in complex with protein Y, hygromycin A, and azithromycin at 2.65A resolution; 16S Ribosomal RNA 8fc6 1A 2872 2.35 RF02541 URS00001698E8_300852 37452045 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacganaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<......>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((..(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...((((((((.(.((((((......)))).)))..))))))))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((...(...........)...))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((.((((((.(......[..(((((..(((......((((((((....))))))))...)))..........].)))))).)))))).)))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..((((.))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the A2058-N6-dimethylated Thermus thermophilus 70S ribosome in complex with protein Y, hygromycin A, and telithromycin at 2.35A resolution; 23S Ribosomal RNA 8fc6 1B 120 2.35 RF00001 URS000080DEE8_300852 37452045 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>. .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the A2058-N6-dimethylated Thermus thermophilus 70S ribosome in complex with protein Y, hygromycin A, and telithromycin at 2.35A resolution; 5S Ribosomal RNA 8fc6 1a 1500 2.35 RF00177,RF01959,RF02542,RF01960 URS000080DFED_300852 37452045 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<..........>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((..)))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((...(((((((....)))))))....(((....)))....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the A2058-N6-dimethylated Thermus thermophilus 70S ribosome in complex with protein Y, hygromycin A, and telithromycin at 2.35A resolution; 16S Ribosomal RNA 8fc6 2A 2867 2.35 RF02541 URS00001698E8_300852 37452045 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacganaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu .<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..................>>>......................>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<..>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<.......<<<<<<......>>>>>>....>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>. .((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((..))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((...((((((......)))).))...)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.........(((.((...(((.......)))....))......................))).....)))))))))).))..........]]].)....))))))))))...)))))))(((((((())))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((..(.((((((.(.........(((((..(((.......((((..........))))....)))............)))))).)))))).)..))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))((((.))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...))). Crystal structure of the A2058-N6-dimethylated Thermus thermophilus 70S ribosome in complex with protein Y, hygromycin A, and telithromycin at 2.35A resolution; 23S Ribosomal RNA 8fc6 2B 120 2.35 RF00001 URS000080DEE8_300852 37452045 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the A2058-N6-dimethylated Thermus thermophilus 70S ribosome in complex with protein Y, hygromycin A, and telithromycin at 2.35A resolution; 5S Ribosomal RNA 8fc6 2a 1504 2.35 RF00177,RF01959,RF02542,RF01960 URS000080DFED_300852 37452045 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>.....<......>....>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((...(((((((....))))))).....((....)).....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the A2058-N6-dimethylated Thermus thermophilus 70S ribosome in complex with protein Y, hygromycin A, and telithromycin at 2.35A resolution; 16S Ribosomal RNA 8feo AAA 16 1.52 URS000291569E_32630 38293747 32630 agaguagaucuucucu ................ ................ 16mer self-complementary duplex RNA with two separated native U:U pairs; RNA 16mer 8fep AAA 16 1.55 URS00029156BC_32630 38293747 32630 agagaaguucuucucu ................ ................ 16mer self-complementary duplex RNA with two continuous native U:U pairs; RNA 16mer 8feq AAA 16 1.5 URS000291569E_32630 38293747 32630 agagnagaucuncucu ................ ................ 16mer self-complementary duplex RNA with two separated s(2)U:s(2)U pairs; RNA 16mer with two separated s(2)U 8fer AAA 16 1.54 URS00029156BC_32630 38293747 32630 agagaagnncuucucu ................ ................ 16mer self-complementary duplex RNA with two continuous s(2)U:s(2)U pairs; RNA 16mer with two continuous s(2)U 8fer BBB 16 1.54 URS00029156BC_32630 38293747 32630 agagaagnncuucucu ................ ................ 16mer self-complementary duplex RNA with two continuous s(2)U:s(2)U pairs; RNA 16mer with two continuous s(2)U 8fiz AA 1534 3.8 RF00177,RF01959,RF02542,RF01960 URS000081169C_562 36931247 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<...................>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>......<.....>......<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>.............<..........<..<<<..<<<.<<<....>>>.>>>...<......>..>>>...>..<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<<..<<.......>>>>.....>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>.....>.......>>.>>>>>>>>.....<<<<<.......<<<..<<...<<<....>>>...>>....>>>.......>>>>>.............<..<.........>..>.............>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ........((((..[.[[[..)))).(..(.(((((..(((((((((....(((.(((..(((..((.((..(((...................)))))..)))))......(((......(((((((..((...(((..((.(.((.....((((((....))))))......)).).....(........)....(((.((...(....).)).))).))..)))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......(.((....)).).....))))..((.(((((...(...(((((((((.......)))))))).)...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..))))))..)..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((....(...((((.........))))...).))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........)).............(.((..(...((...(...(...(((....)))...)..............)....))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((..((((((...((..((.......))))....))))))...(..(((((.....))))).....)..)))).....).).)))...)).)))))....))).......)).)))))))).(......((.......(((..((...(((....)))...))....))).......)).........(.....((...(........)...)).....)..)..))))).....((((.((.........)).))))......))...)))))))))).))..(.(...(.(.((((.(((..((((((((((((....(((((..((((..((....)).)))).)))))...))))))))))))..))).))))..).)....)..)..(((((((((....)))))))))}..... Cryo-EM structure of E. coli 70S Ribosome containing mRNA and tRNA (in the transcription-translation complex); 16S rRNA 8fiz AW 17 3.8 36931247 2681611 cugaaugcggcgggucu ................. ................. Cryo-EM structure of E. coli 70S Ribosome containing mRNA and tRNA (in the transcription-translation complex); mRNA 8fiz BA 2897 3.8 RF02541 URS00004B0F34_562 36931247 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu .<<..<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<.<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>.>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<..........>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<....<<...<<........<<<<<......<<<.........>>>...........................>>>>>....>>..>>....>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<........>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....[[....>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<..<<....>>...>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<...........................<.........<<.<<<....>>>.>>......>............................>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>........<<<...<<<<<<...<<.......>>...>>>>>>....>>>.........<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.]].>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>..>>.. ......((......((((((((((.....(((..(((((((((((((......(((((..[..[[[..)).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((..((((.(((.(((...(((((......)))))[[(...).(((.....]])))...)))...))).))))..)))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..))))...(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((.........<..))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...((..((((...((..(...)...))...))))..))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(.(.(..(.(.....{..((((......((...........))..........(..............).))))....).)..))..).))...........]]].)...))))))))))...)))))))(((((((........)))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((.(..(((..((((((((((((...{{..).))))))(...((((...((((((((((((.((.....))))))))))..))))..[))))....)(...((((....))))....))))))...)))...).))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((.(((.].((.........))...(((((((.....(((....))).......))))))).}((((..((..(((((((..(((........(((((..((....))...)))))........))))))))..)))).(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).).))))).)..))).)))))))).)))))).....)).[..(((((......].)))))..((((((((.(((.((......((((...((((..(((((.(((.(((((.((.(((..(........(............(...(((........(..(.(....).)..).....))).............)...)........)..))).))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))....))))......(.(((.(.((((((...((.......))...))))))...))))...)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....(((.((((..((....(((((....)))))...))...))))..))).....))..).)))....... Cryo-EM structure of E. coli 70S Ribosome containing mRNA and tRNA (in the transcription-translation complex); 23S rRNA 8fiz BB 75 3.8 RF00005 URS000041AF00_562 36931247 0030533 0006412 562 cgcgggguggagcagccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacc .<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>.... .(((.((..((((........)))).(((((.......))))).....(.(((.......))).))).))).... Cryo-EM structure of E. coli 70S Ribosome containing mRNA and tRNA (in the transcription-translation complex); P-site tRNA 8fiz BC 120 3.8 RF00001 URS0000049E57_562 36931247 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. .(((((((.(.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...).))))))).. Cryo-EM structure of E. coli 70S Ribosome containing mRNA and tRNA (in the transcription-translation complex); 5s rRNA 8fjk a1 52 3.3 URS00026813A4_185783 36856784 185783 uauauauauauauauauauauauauauauauauauauauauauauauauaua .................................................... .................................................... Golden Shiner Reovirus Core Polar Vertex; RNA (52-MER) 8fjk a2 60 3.3 URS00026813B9_185783 36856784 185783 uauauauauauauauauauauauauauauauauauauauauauauauauauauauauaua ............................................................ ............................................................ Golden Shiner Reovirus Core Polar Vertex; RNA (60-MER) 8fjk a3 40 3.3 URS00026813B5_185783 36856784 185783 uauauauauauauauauauauauauauauauauauauaua ........................................ ........................................ Golden Shiner Reovirus Core Polar Vertex; RNA (40-MER) 8fjk a4 18 3.3 URS0000E60BC2_185783 36856784 185783 uauauauauauauauaua .................. .................. Golden Shiner Reovirus Core Polar Vertex; RNA (18-MER) 8fjk a5 38 3.3 URS00026813A0_185783 36856784 185783 uauauauauauauauauauauauauauauauauauaua ...................................... ...................................... Golden Shiner Reovirus Core Polar Vertex; RNA (38-MER) 8fjk a6 30 3.3 URS00026813CA_185783 36856784 185783 uauauauauauauauauauauauauauaua .............................. .............................. Golden Shiner Reovirus Core Polar Vertex; RNA (30-MER) 8fjk b1 52 3.3 URS00026813A4_185783 36856784 185783 uauauauauauauauauauauauauauauauauauauauauauauauauaua .................................................... .................................................... Golden Shiner Reovirus Core Polar Vertex; RNA (52-MER) 8fjk b2 60 3.3 URS00026813B9_185783 36856784 185783 uauauauauauauauauauauauauauauauauauauauauauauauauauauauauaua ............................................................ ............................................................ Golden Shiner Reovirus Core Polar Vertex; RNA (60-MER) 8fjk b3 40 3.3 URS00026813B5_185783 36856784 185783 uauauauauauauauauauauauauauauauauauauaua ........................................ ........................................ Golden Shiner Reovirus Core Polar Vertex; RNA (40-MER) 8fjk b4 18 3.3 URS0000E60BC2_185783 36856784 185783 uauauauauauauauaua .................. .................. Golden Shiner Reovirus Core Polar Vertex; RNA (18-MER) 8fjk b5 38 3.3 URS00026813A0_185783 36856784 185783 uauauauauauauauauauauauauauauauauauaua ...................................... ...................................... Golden Shiner Reovirus Core Polar Vertex; RNA (38-MER) 8fjk b6 30 3.3 URS00026813CA_185783 36856784 185783 uauauauauauauauauauauauauauaua .............................. .............................. Golden Shiner Reovirus Core Polar Vertex; RNA (30-MER) 8fjl a5 28 3.27 URS00026813AB_185783 36856784 185783 uauauauauauauauauauauauauaua ............................ ............................ Golden Shiner Reovirus Core Tropical Vertex; RNA (38-MER) 8fjl b5 28 3.27 URS00026813AB_185783 36856784 185783 uauauauauauauauauauauauauaua ............................ ............................ Golden Shiner Reovirus Core Tropical Vertex; RNA (38-MER) 8fjl b6 38 3.27 URS00026813A0_185783 36856784 185783 uauauauauauauauauauauauauauauauauauaua ...................................... ...................................... Golden Shiner Reovirus Core Tropical Vertex; RNA (30-MER) 8fjl a6 38 3.27 URS00026813A0_185783 36856784 185783 uauauauauauauauauauauauauauauauauauaua ...................................... ...................................... Golden Shiner Reovirus Core Tropical Vertex; RNA (30-MER) 8fjl a1 52 3.27 URS00026813A4_185783 36856784 185783 uauauauauauauauauauauauauauauauauauauauauauauauauaua .................................................... .................................................... Golden Shiner Reovirus Core Tropical Vertex; RNA (52-MER) 8fjl b1 52 3.27 URS00026813A4_185783 36856784 185783 uauauauauauauauauauauauauauauauauauauauauauauauauaua .................................................... .................................................... Golden Shiner Reovirus Core Tropical Vertex; RNA (52-MER) 8fjl a3 40 3.27 URS00026813B5_185783 36856784 185783 uauauauauauauauauauauauauauauauauauauaua ........................................ ........................................ Golden Shiner Reovirus Core Tropical Vertex; RNA (39-MER) 8fjl b3 40 3.27 URS00026813B5_185783 36856784 185783 uauauauauauauauauauauauauauauauauauauaua ........................................ ........................................ Golden Shiner Reovirus Core Tropical Vertex; RNA (39-MER) 8fjl a2 60 3.27 URS00026813B9_185783 36856784 185783 uauauauauauauauauauauauauauauauauauauauauauauauauauauauauaua ............................................................ ............................................................ Golden Shiner Reovirus Core Tropical Vertex; RNA (60-MER) 8fjl b2 60 3.27 URS00026813B9_185783 36856784 185783 uauauauauauauauauauauauauauauauauauauauauauauauauauauauauaua ............................................................ ............................................................ Golden Shiner Reovirus Core Tropical Vertex; RNA (60-MER) 8fkp L1 152 2.85 RF00002,RF02540 URS0000005270_9606 37410842 0003735 0005840 9606 acucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguucccggggcuacgccugucugagcgucgcuu .......................................<<<<<<<<<....>>>>.....<.<<<......>>.............>>>..>...>>>....<<....>><<<<<<<<<..>>>>>>>>>..................... .......................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))(((((((((..)))))))))..................... Human nucleolar pre-60S ribosomal subunit (State A1); 5.8S rRNA 8fkp L3 1507 2.85 RF02543 URS000075EC78_9606 37410842 0003735 0005840 9606 gcgaccucagaucagacguggcgacccgcuggcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagaggacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucgggcccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccggcggcgacgucggcuacccacccgacccgucacggaccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaggugggaucccgaggccaguccgccgagggcgcaccaccggccgcacgagcgcacguguuaggacccgaagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcaguuuuauccgggguaagaagccggcguggaaugcgagugccuagugggccacuuuuagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucggcgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacggcgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaauguuggaacaauguaggaccuacuauccagcgaaaccucagcacugaugaguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggcccgcccaggcggaacgauagcgccgcggagccucgguuggccucggauagccgguccccgggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagagcccucgacacgguuugu ........................<<<<<<............>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<.<<<...<<<<<<<<<<.>>>>>>.>>>>.....>>>.>..<<<<<<<<<<...<<<<<<<<.<<.....<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>.>>>>>>>>>>..>>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<<.>>>>>>..>>>..................................<<....>>...............<<<<....>>>>...............................<<<<<<<<..<<<......<<<<<<<<.<<<.....<<<<<<<<<<..>>>>>>>>>>......>>>.>>>.>>>>>..<<<<<<...<<<<<<<<<<<<<<<...<<..<<<.<<.<<<<......<<<<<<..>>>>>>.......>>>>>>.>>>........>>>>>>..>>>>>>>>>>>>>>>>>....>>>...>>>>>>>>..<<<...>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>....<<<<<...<<<..<<........>>..>>>....>>>>>.<<.>>....>>>>>>>>>>>>>..<<.<...>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<..<<<.<<<<<<<<.>>>>>>...<<..>>....>>>>>>>>>>>>..>>..<<<<.<<<..>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<..)))......>>>>>..>>>...>>>>>>><<<<<<.<<<..............<.>...........>>>>>>>>>....>>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>>.<.....<......<<<<.....<<<<<.>>>>>..>>>>.>....>.<<<<..>>>>...<<<<<<.<..<<<....<<<<<.................>>>>>..<<<<....<<<<...<.<..<<<<<<....>>>>>>....>...>>>>>...>>>><<<..>>>.>>>...>.>>>>>>.<<<<<<.<<..<<<<....<<<........<<<<<.<<<<>>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>..............>>>>..>>>>>>>>.<<<<<.<.............>..<.<<<<<<<<<<.....<<<<....<<<<<......>>>>>...>>>>....>>.>>>>>.>>>.>>>>>>.. ........................(((((...[..........)))).).........((....))...((((......((.....)).....))))...((((...(((...((((((((((.)))))).)))).....)))....((((((((((...((((((((.((.....((((((((..({((((......)))))....[[(...).(((....}]])))...).))))))).))))))))))..))))))))))..)....(((((((....]...))))))).....((((((.))))))..)))..................................((....))............(..((((....))))............)..................((((((((..((((.....((((((((.(((.....((((((((((()))))))))))......))).))).)))))..((((((...(((((((((((((((...((..(((.((.((((......((((((())))))).......)))))).)))........))))))..)))))))))))))))))..).)))...))))))))..((.....))((((((..(.(((((((((((((..(((..((((..........)))..)..)))....(((((...(((..(((......)))..)))....))))).((.))....)))))))))))))..((.(...).))).((((((....(.(((....))).)((.(((((((..(((.((((((((.))))))...((()))....))))))))))))..))..((((.(((()))).))))....(((......)))...(((((((...((([[[...(.(.(((((..]]]......))))))))))...)))))))((((((.(((.............((.))..........)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((.....(((((.)))))..))))))....))((((..))))...((((((.(..(((....(((((......(....).....)))))..((((....((((...[((.(((((((....)))))).)..))...))))...)))).((()))..)))...).)))))).(((((..((..((((.(..(((........(((((.(((()))).))))).......)))...(((..((((....((((.(((((((......)))))))))))...))))..)))...........)..))))..)).))))).(((((.(..(.......)..)..(.((((((((((.....((((.(..(((((......)))))..)))))....))]))))).))).)))))).. Human nucleolar pre-60S ribosomal subunit (State A1); 28S rRNA 8fkq L1 150 2.76 RF00002 URS0000005270_9606 37410842 0003735 0005840 9606 acucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcucugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguucccggggcuacgccugucugagcgucgcuu .......................................<<<<<<<<<..>>>>.....<.<<<......>>.............>>>..>...>>>....<<....>><<<<<<<<<..>>>>>>>>>..................... .......................................((((((.[[...))).....(.(((......]].............)))..)...)))....((....))(((((((((..)))))))))..................... Human nucleolar pre-60S ribosomal subunit (State A2); 5.8S rRNA 8fkq L3 1565 2.76 RF02543 URS000075EC78_9606 37410842 0003735 0005840 9606 gcgaccucagaucagacguggcgacccgcuggcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagaggaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucgggcccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgccgcgcucuccggccgggccaggccacgcgagcgcacggggucggcggcgacgucggcuacccacccgacccgucuacacggaccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaggugggaucccgaggccgccgagggcgcaccaccggccgcacgagcgcacguguuaggacccgaaagauggugaaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcaguuuuauccgguggguaagaagccggcguggaaugcgagugccuagugggccacuuuuagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucggcgcuggagcgucgggcccauacccggccgucgccggcagucacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaauguuggaacaauguaggaccuacuauccagcgaaaccucagcacugaugauguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggcccgcccaggcggaacgauagcgccgcggagccucgguuggccucggauagccgguccccgggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagagcccucgacacgguuugu ........................<<<<<<............>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<<...<<<<<<<<<<.>>>>>>.>>>>.....>>>>>..<<<<<<<<<<...<<<<<<<<.<<.....<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>.>>>>>>>>>>..>>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<<.>>>>>>..>>>..................................<<....>>...............<<<<....>>>>................................<<<<<<<<.<<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<<..>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<.<<<<<<<<<<<<<<<...<<..<<<.<<.<<<<......<<<<<<..>>>>>>.......>>>>>>.>>>........>>>>>>..>>>>>>>>>>>..........<<<<<<.<..>.<<<<<<.>>>>.>>.>>>>>>......>>.>>>>>...>>>>>..>>>>>>>>>..<<<<....>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>....<<<<<...<<<..<<<.>>>..>>>....>>>>>.<<.>>....>>>>>>>>>>>>>..<<.<...<<<<<<...>>>>>>......>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<..<<<.<<<<<<<<...>>>>>>...<<..>>....>>>>>>>>>>>>..>>..<<<<.<<<..>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<..)))......>>>>>..>>>...>>>>>>><<<<<<.<<<...........>>>>>>>>>....>>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>>.<.....<......<<<<.....<<<<<.>>>>>..>>>>.>....>.<<<<..>>>>....<<<<<<.<..<<<....<<<<<.................>>>>>..<<<<....<<<<.....<..<<<<<<....>>>>>>....>....>>>>...>>>><<<..>>>.>>>...>.>>>>>>.<<<<<<.<<..<<<<....<<<........<<<<<.<<<<>>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>..............>>>>..>>>>>>>>.<<<<<.<.............>....<<<<<<<<<<.....<<<<....<<<<<......>>>>>...>>>>....>>.>>>>>.>>>..>>>>>.. ........................(((((...[..........)))).).........((....))...((((......((.....)).....))))...((((...(((...((((((((((.)))))).)))).....)))....((((((((((...((((((((.((.....((((((((..({((((......)))))....[[(...).(((....}]])))...).))))))).))))))))))..))))))))))..)....(((((((....]...))))))).....((((((.))))))..)))..................................((....))............(..((((....))))............)...................((((((((..(((.((...((((((((.(((.....((((((((((()))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((.(..((((......((((((())))))).......)))).).)))........))))))..)))))))))))..........((((((.(()).((((((.)))).)).)))))).....))).)))))...)))))...))))))))..((((....))))((((((..(.(((((((((((((..(((..((((..........)))..)..)))....(((((...(((..(((.)))..)))....))))).((.))....)))))))))))))..((.(...((((((...))))))......).))).((((((....(.(((....))).)((.(((((((..(((.((((((((...))))))...((()))....))))))))))))..))..((((.(((()))).))))....(((......)))...(((((((...((([[[...(.(.(((((..]]]......))))))))))...)))))))((((((.(((...........)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((.....(((((.)))))..))))))....))((((..))))....((((((.(..(((..(.(((((......(....).....))))).)((((....((((...[((.(((((((....)))))).)..))...))))...)))).((()))..)))...).)))))).(((((..((..((((.(..(((........(((((.(((()))).))))).......)))...(((..((((....((((.(((((((......)))))))))))...))))..)))...........)..))))..)).))))).(((((.(..(.......)..)..(.((((((((((.....((((.(..(((((......)))))..)))))....))]))))).))).)))))).. Human nucleolar pre-60S ribosomal subunit (State A2); 28S rRNA 8fkr L1 154 2.89 RF00002,RF02540 URS0000005270_9606 37410842 0003735 0005840 9606 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguucccggggcuacgccugucugagcgucgcuu .........................................<<<<<<<<<....>>>>.....<.<<<......>>.............>>>..>...>>>....<<....>><<<<<<<<<..>>>>>>>>>..................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))(((((((((..)))))))))..................... Human nucleolar pre-60S ribosomal subunit (State B1); 5.8S rRNA 8fkr L3 1767 2.89 RF02543 URS000075EC78_9606 37410842 0003735 0005840 9606 gcgaccucagaucagacguggcgacccgcugagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagaggacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucgggcccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagcggcgacgucggcuacccacccgacccgucuacacggaccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaggugggaucccgaggccaguccgccgagggcgcaccaccggcccgucucgcccggggagguggagcacgagcgcacguguuaggacccgaagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcaguuuuauccgggguaagaagcccggcucgagccgggcguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucacccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacggcgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaauguuggaacaauguaggaccuacuauccagcgaaaccagccaagcuuggcucagccuggcuuguggcggccaagcgcgacgucgcuuuuugugugaagcagaauucaccaaacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauagcgccgcggagccucgguuggccucggauagccgguccccgggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagagcccucgacacgguuugu ........................<<<<<<.............>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<<...<<<<<<<<<<.>>>>>>.>>>>.....>>>>>..<<<<<<<<<<...<<<<<<<<.<<.....<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>.>>>>>>>>>>..>>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<<.>>>>>>..>>>..................................<<....>>...............<<<<....>>>>...............................<<<<<<<<..<<<......<<<<<<<<.<<<.....<<<<<<<<<<..>>>>>>>>>>......>>>.>>>.>>>>>..<<<<<<...<<<<<<<<<<<<<<<...<<..<<<.<<.<<<<......<<<<<<..>>>>>>.......>>>>>>.>>>........>>>>>>..>>>>>>>>>>>.>>>>>>....>>>...>>>>>>>>..<<<<....>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>....<<<<<...<<<..<<........>>..>>>....>>>>>.<<<<<<<<<.<<..>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<...>.>>..<<<<<<......<<<....>>>..<<.<<<<<<<..<<<.<<<<<<<<.>>>>>>...<<<<<<<<..>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<...[[>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<....<<<....<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>.....>>>..)))......>>>>>..>>>...>>>>>>><<<<<<.<<<..............<.>...........>>>>>>>>>....>>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<......<<<<.....<<<<<.>>>>>..>>>>.>....>>.<<<<<<>>>>>><<<<.]].......<<<<<<...<..>...>>>>>>......<<<<<......>>>>>....>>>>......<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<...<.<..<<<<<<....>>>>>>....>...>>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.<<<<<<.<<..<<<<....<<<........<<<<<.<<<<>>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>..............>>>>..>>>>>>>>.<<<<<.<.............>....<<<<<<<<<<.....<<<<.<..<<<<<......>>>>>..>>>>>....>>.>>>>>.>>>..>>>>>.. ........................(((((....[..........)))).).........((....))...((((......((.....)).....))))...((((...(((...((((((((((.)))))).)))).....)))....((((((((((...((((((((.((.....((((((((..({((((......)))))....[[(...).(((....}]])))...).))))))).))))))))))..))))))))))..)....(((((((....]...))))))).....((((((.))))))..)))..................................((....))............(..((((....))))............)..................((((((((..((((.....((((((((.(((.....((((((((((()))))))))))......))).))).)))))..((((((...(((((((((((((((...((..(((.((.((((......((((((())))))).......)))))).)))........))))))..))))))))))).))))))..).)))...))))))))..((((....))))((((((..(.(((((((((((((..(((..((((..........)))..)..)))....(((((...(((..(((......)))..)))....))))).(((((((((.((()))))))))).))....)))))))))))))..((.(...).))).((((((....(.(((....))).)((.(((((((..(((.((((((((.))))))...((((((((()))))))))....))))))))))))..))..((((.(((((....[))))).))))....(((......)))...(((((((...((([[[...(.(.(((((....(((....(((.((((((((((.......(((((.(((...((.........))...))).....(...((......)).).)))))...))))))))))))).....)))..]]]......))))))))))...)))))))((((((.(((.............((.))..........)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((.....(((((.)))))..))))))....)).(.(((()))).)((((.]........((((((...(..)...))))))......(((((......)))))....))))......((((((.(..(((..(..((((......(....).....))))..)((((....((((...[((.(((((((....)))))).)..))...))))...)))).((((...((((.............))))...))))..)))...).)))))).(((((..((..((((.(..(((........(((((.(((()))).))))).......)))...(((..((((....((((.(((((((......)))))))))))...))))..)))...........)..))))..)).))))).(((((.(..(.......)..)..(.((((((((((.....((((.(..(((((......)))))..)))))....))]))))).))).)))))).. Human nucleolar pre-60S ribosomal subunit (State B1); 28S rRNA 8fks L1 152 2.88 RF00002,RF02540 URS0000005270_9606 37410842 0003735 0005840 9606 acucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguucccggggcuacgccugucugagcgucgcuu .......................................<<<<<<<<<....>>>>.....<.<<<......>>.............>>>..>...>>>....<<....>><<<<<<<<<..>>>>>>>>>..................... .......................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))(((((((((..)))))))))..................... Human nucleolar pre-60S ribosomal subunit (State B2); 5.8S rRNA 8fks L3 1824 2.88 RF02543 URS000075EC78_9606 37410842 0003735 0005840 9606 gcgaccucagaucagacguggcgacccgcugaaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagaggacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucgggcccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgccgcgcucuccggccgggccaggccacgcgagcgcacggggucggcggcgacgucggcuacccacccgacccgucuacacggaccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaggugggaucccgaggcgccgagggcgcaccaccggcccgucucgcccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucuccgcaguuuuauccgggguaagaagcccggcucgagccgggcguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucacccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaauguuggaacaauguaggaccuacuauccagcgaaaccagccaagcuuggcucagcggggcuggcuuguggcggccaagcgcgacgucgcuuuuugauugugaagcagaauucaccaacccuacugaugguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauagcgccgcggagccucgguuggccucggauagccgguccccgggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagagcccucgacacgguuugu ........................<<<<<<...............>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<...<<<<...<<<<<<<<<<.>>>>>>.>>>>.....>>>>...<<<<<<<<<<...<<<<<<<<.<<.....<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>.>>>>>>>>>>..>>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<<.>>>>>>..>>>..................................<<....>>...............<<<<....>>>>...............................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<<..>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<.<<<<<<<<<<<<<<<...<<..<<<.<<.<<<<......<<<<<<..>>>>>>.......>>>>>>.>>>........>>>>>>..>>>>>>>>>>>..........<<<<<<.<..>.<<<<<<.>>>>.>>.>>>>>>......>>.>>>>>...>>>>>...>>>>>>>>..<<<<....>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>....<<<<<...<<<..<<<>>>..>>>....>>>>>.<<<<<<<<<.<<..>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<...<<<<<<..>>>>>>......>.>>..<<<<<<......<<<....>>>..<<.<<<<<<<...<<<.<<<<<<<<.>>>>>>...<<<<<<<<..>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<...[[>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<....<<<....<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>.....>>>..)))......>>>>>..>>>...>>>>>>><<<<<<.<<<...........>>>>>>>>>....>>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<......<<<<.....<<<<<.>>>>>..>>>>.>....>>.<<<<<<>>>>>><<<<.<<<<]].......<<<<<<...<..>...>>>>>>........<<<<<......>>>>>...>>>>.>>>>..<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<...<.<..<<<<<<....>>>>>>....>...>>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.<<<<<<.<<..<<<<....<<<........<<<<<.<<<<>>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>..............>>>>..>>>>>>>>.<<<<<.<.............>....<<<<<<<<<<.....<<<<....<<<<<......>>>>>...>>>>....>>.>>>>>.>>>..>>>>>.. ........................(((((......[..........)))).).........((....))...((((......((.....)).....))))...((((...(((...((((((((((.)))))).)))).....)))....((((((((((...((((((((.((.....((((((((..({((((......)))))....[[(...).(((....}]])))...).))))))).))))))))))..))))))))))..)....(((((((....]...))))))).....((((((.))))))..)))..................................((....))............(..((((....))))............)..................((((((((..(((.((...((((((((.(((.....((((((((((()))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((.(..((((......((((((())))))).......)))).).)))........))))))..)))))))))))..........((((((.(()).((((((.)))).)).)))))).....))).)))))...)))))...))))))))..((((....))))((((((..(.(((((((((((((..(((..((((..........)))..)..)))....(((((...(((..((()))..)))....))))).(((((((((.((()))))))))).))....)))))))))))))..((.(...((((((..))))))......).))).((((((....(.(((....))).)((.(((((((...(((.((((((((.))))))...((((((((()))))))))....))))))))))))..))..((((.(((((....[))))).))))....(((......)))...(((((((...((([[[...(.(.(((((....(((....(((.((((((((((.......(((((.(((...((.........))...))).....(...((......)).).)))))...))))))))))))).....)))..]]]......))))))))))...)))))))((((((.(((...........)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((.....(((((.)))))..))))))....)).(.(((()))).)((((.((((]........((((((...(..)...))))))........(((((......)))))...)))).))))..((((((.(..(((..(..((((......(....).....))))..)((((....((((...[((.(((((((....)))))).)..))...))))...)))).((((...((((.............))))...))))..)))...).)))))).(((((..((..((((.(..(((........(((((.(((()))).))))).......)))...(((..((((....((((.(((((((......)))))))))))...))))..)))...........)..))))..)).))))).(((((.(..(.......)..)..(.((((((((((.....((((.(..(((((......)))))..)))))....))]))))).))).)))))).. Human nucleolar pre-60S ribosomal subunit (State B2); 28S rRNA 8fkt L1 152 2.81 RF00002,RF02540 URS0000005270_9606 37410842 0003735 0005840 9606 acucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguucccggggcuacgccugucugagcgucgcuu .......................................<<<<<<<<<....>>>>.....<.<<<......>>.............>>>..>...>>>....<<....>><<<<<<<<<..>>>>>>>>>..................... .......................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))(((((((((..)))))))))..................... Human nucleolar pre-60S ribosomal subunit (State C1); 5.8S rRNA 8fkt L3 2125 2.81 RF02543 URS000075EC78_9606 37410842 0003735 0005840 9606 gcgaccucagaucagacguggcgacccgcugaaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagaggaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucgggcccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgaggggucggcggcgacgucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaggugggaucccgaggcccaguccgccgagggcgcaccaccggccgcacgagcgcacguguuaggacccgaaagauggugaaaccaucuaguagcugguucccuccgaaguuucccggauagcuggcgcucuccgcaguuuuauccgguggguaagaagccggcguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacggccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaggggcgauggccuccggcccucgcggagaugggcgccgcgaggcguccagugaaucucgcauguagguaagggaaguacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggagaagacccuguugagcuugacucuagucuggcacggugaagagacaugagagguguagaauaagugggaggcggccgccggugaaauaccacuacucugaucguuuuuuccagugccagguggggaguuauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcgcgacgucgcuuuuugaugaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggggucgugagaccccuacugaugguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguggugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauaagcgccgcggagccucgguuggccucggauagccgguccccgggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu ........................<<<<<<...............>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<.<<<...<<<<<<<<<<.>>>>>>.>>>>.....>>>.>..<<<<<<<<<<...<<<<<<<<.<<.....<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>.>>>>>>>>>>..>>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<<.>>>>>>..>>>..................................<<....>>...............<<<<....>>>>................................<<<<<<<<..<<<......<<<<<<<<.<<<.....<<<<<<<.>>>>>>>......>>>.>>>.>>>>>..<<<<<<<<.<<<<<<<<<<<<<<<...<<..<<<.<<.<<<<......<<<<<<..>>>>>>.......>>>>>>.>>>........>>>>>>..>>>>>>>>>>>.....>>.>>>>>>....>>>...>>>>>>>>..<<<<.<....>.>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>....<<<<<...<<<..<<.........>>..>>>....>>>>>.<<.>>....>>>>>>>>>>>>>..<<.<...<<<<<<...>>>>>>......>.>>..<<<<<<....<.<<<.>>>.><<.<<<<<<<...<<<.<<<<<<<<...>>>>>>...<<..>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.....<.<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>.>.>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<.............<<..>>..........>>>>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<...<<<<...........>>>>..<<<<<...<<<<<<<....>>>>>>>......>>.>>>..<<<<<<.<<<<<<<..>>.>>>>>>>>>>>.......>....>>...<<<<<<........>>>>>>....<<<<.<<<<......<<<<<<.<<<<<<.<<<<<.<<<<<<<<<...<<<<<<<<<<.<<<<..........<<<<<..<<<.>>>............>>>>>.>>>>.>>.>>>>>>>>..>>>>>>>>>..>>>>>...<<<<<<<..<<<.........>>>>>>>>>>........>>>>>.>.>>>>>>.............<<<<<<...<..>...>>>>>>.......((...<<<<<<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.....))..>>>.....>>>>>....>>>>>>..<<<....>>>>>>>.>>>>..<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<.<<.<<<<<<<....>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.<<<<<<<.<<..<<<<....<<<........<<<<<.<<<<>>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>..............>>>>..>>>>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<....<<<<<......>>>>>...>>>>....>>....>>>>.>>>.>>..>>>>>.. ........................(((((......[..........)))).).........((....))...((((......((.....)).....))))...((((...(((...((((((((((.)))))).)))).....)))....((((((((((...((((((((.((.....((((((((..({((((......)))))....[[(...).(((....}]])))...).))))))).))))))))))..))))))))))..)....(((((((....]...))))))).....((((((.))))))..)))..................................((....))............(..((((....))))............)...................((((((((..((((.....((((((((.(((.....(((((((.)))))))......))).))).)))))..((((((((((((((((((((((((...((..(((.((.((((......((((((())))))).......)))))).)))........))))))..)))))))))))....))).))))))..).)))...))))))))..((((........))))((((((..(.(((((((((((((..(((..((((..........)))..)..)))....(((((...(((..(((.......)))..)))....))))).((.))....)))))))))))))..((.(...((((((...))))))......).))).((((((....(.(((.))).)((.(((((((...(((.((((((((...))))))...((()))....))))))))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.(((((......(....{.....(((.((((((((((.....<.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((.............((()))..........)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((..((((...........))))..(((((...(((((((....)))))))......)).)))..((((((.(((((((())).)))))))))))......))....)).[.((((((......].))))))....((((.((((.(....((((((.((((((.(((((.(((((((((...((((((((((.((((.......[..(((((..(((.)))..........].))))).)))).)).))))))))..)))))))))..)))))....((((((..(((.........))))))))).........))))).).))))))....).[}.....((((((...(())...)))))).......[[...(((((((((((..(.(.(((((......)))))...).).(((.....]]..))).....))))).]..))))))..(((....))))))).))))..((((((.(..(((..(.(((((......(....).....))))).)((((....((((.((.(((((((....)))))..)).))...))))...)))).((((...((((.....>.......))))...))))..)))...).)))))).(((((((.((..((((.(..(((........(((((.(((()))).))))).......)))...(((..((((....((((.(((((((......)))))))))))...))))..)))...........)..))))..)))))))))(((((.(..(.......)..)....((.(((((((.((.....((((.(..((.((......)).))..)))))....))....)))).))).))..))))).. Human nucleolar pre-60S ribosomal subunit (State C1); 28S rRNA 8fku L1 152 2.82 RF00002,RF02540 URS0000005270_9606 37410842 0003735 0005840 9606 acucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguucccggggcuacgccugucugagcgucgcuu .......................................<<<<<<.<<.....>>>.....(.<<<......>>.............>>>..)...>>>....<<....>><<<<<<<<<..>>>>>>>>>..................... .......................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))(((((((((..)))))))))..................... Human nucleolar pre-60S ribosomal subunit (State C2); 5.8S rRNA 8fku L3 2185 2.82 RF02543 URS000075EC78_9606 37410842 0003735 0005840 9606 gcgaccucagaucagacguggcgacccgcugaaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagaggaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucgggcccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgccgcgcucuccggccgggccaggccacggagcgcacggggucggcggcgacgucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaggugggaucccgaggcccgccgagggcgcaccaccggcccgucucgcccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaaaccaucuaguagcugguucccuccgaaguuucccggauagcuggcgcucuccgcaguuuuauccgguggguaagaagcccggcucgagccgggcguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaggggcgauggccuccggcccucgcggagaugggcgccgcgaggcguccagugaaucucgcauguagguaagggaaguacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggagaagacccuguugagcuugacucuagucuggcacggugaagagacaugagagguguagaauaagugggaggcggccgccggugaaauaccacuacucugaucguuuuuuccagugccagguggggaguuauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcgcgacgucgcuuuuugaugaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggggucgugagaccccuacugaugguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguggugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauaagcgccgcggagccucgguuggccucggauagccgguccccgggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu ........................<<<<<<...............>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<<...<<<<<<<<<<.>>>>>>.>>>>.....>>>>>..<<<<<<<<<<...<<<<<<<<.<<.....<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>.>>>>>>>>>>..>>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<<.>>>>>>..>>>..................................<<....>>...............<<<<....>>>>................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<<..>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<.<<<<<<<<<<<<<<<...<<..<<<.<<.<<<<......<<<<<<..>>>>>>.......>>>>>>.>>>........>>>>>>..>>>>>>>>>>>..........<<<<<<.<..>.<<<<<<.>>>>.>>>>>>>>......>>.>>>>>...>>>>>...>>>>>>>>..<<<<.<....>.>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>....<<<<<...<<<..<<<..>>>..>>>....>>>>>.<<<<<<<<<.<<..>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<...<<<<<<...>>>>>>......>.>>..<<<<<<....<.<<<.>>>.><<.<<<<<<<...<<<.<<<<<<<<...>>>>>>...<<<<<<<<..>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.....<.<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>.>.>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<...........>>>>>>>>>....>>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<<....<...<<<<...........>>>>..<<<<<...<<<<<<<....>>>>>>>......>>.>>>..<<<<<<.<<<<<<<..>>.>>>>>>>>>>>.......>...>>>...<<<<<<........>>>>>>....<<<<.<<<<......<<<<<<.<<<<<<.<<<<<.<<<<<<<<<...<<<<<<<<<<.<<<<..........<<<<<..<<<.>>>............>>>>>.>>>>.>>.>>>>>>>>..>>>>>>>>>..>>>>>...<<<<<<<..<<<.........>>>>>>>>>>........>>>>>.>.>>>>>>.............<<<<<<...<..>...>>>>>>.......((...<<<<<<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.....))..>>>.....>>>>>....>>>>>>..<<<....>>>>>>>.>>>>..<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<.<<.<<<<<<<....>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.<<<<<<<.<<..<<<<....<<<........<<<<<.<<<<>>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>..............>>>>..>>>>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<....<<<<<......>>>>>...>>>>....>>....>>>>.>>>.>>..>>>>>.. ........................(((((......[..........)))).).........((....))...((((......((.....)).....))))...((((...(((...((((((((((.)))))).)))).....)))....((((((((((...((((((((.((.....((((((((..({((((......)))))....[[(...).(((....}]])))...).))))))).))))))))))..))))))))))..)....(((((((....]...))))))).....((((((.))))))..)))..................................((....))............(..((((....))))............)...................((((((((..(((.((...((((((((.(((.....((((((((((()))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((.((.((((......((((((())))))).......)))))).)))........))))))..)))))))))))..........((((((.(()).((((((.)))).)))))))).....))).)))))...)))))...))))))))..((((........))))((((((..(.(((((((((((((..(((..((((..........)))..)..)))....(((((...(((..(((..)))..)))....))))).(((((((((.((()))))))))).))....)))))))))))))..((.(...((((((...))))))......).))).((((((....(.(((.))).)((.(((((((...(((.((((((((...))))))...((((((((()))))))))....))))))))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.(((((......(....{.....(((.((((((((((.....<.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((...........)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((..((((...........))))..(((((...(((((((....)))))))......)).)))..((((((.(((((((())).)))))))))))......))....)).[.((((((......].))))))....((((.((((.(....((((((.((((((.(((((.(((((((((...((((((((((.((((.......[..(((((..(((.)))..........].))))).)))).)).))))))))..)))))))))..)))))....((((((..(((.........))))))))).........))))).).))))))....).[}.....((((((...(())...)))))).......[[...(((((((((((..(.(.(((((......)))))...).).(((.....]]..))).....))))).]..))))))..(((....))))))).))))..((((((.(..(((..(.(((((......(....).....))))).)((((....((((.((.(((((((....)))))..)).))...))))...)))).((((...((((.....>.......))))...))))..)))...).)))))).(((((((.((..((((.(..(((........(((((.(((()))).))))).......)))...(((..((((....((((.(((((((......)))))))))))...))))..)))...........)..))))..)))))))))(((((.(..(.......)..)....((.(((((((.((.....((((.(..((.((......)).))..)))))....))....)))).))).))..))))).. Human nucleolar pre-60S ribosomal subunit (State C2); 28S rRNA 8fkv L1 152 2.47 RF00002,RF02540 URS0000005270_9606 37410842 0003735 0005840 9606 acucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguucccggggcuacgccugucugagcgucgcuu .......................................<<<<<<<<<....>>>>.....<.<<<......>>.............>>>..>...>>>....<<....>><<<<<<<<<..>>>>>>>>>..................... .......................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))(((((((((..)))))))))..................... Human nucleolar pre-60S ribosomal subunit (State D1); 5.8S rRNA 8fkv L3 2213 2.47 RF02543 URS000075EC78_9606 37410842 0003735 0005840 9606 gcgaccucagaucagacguggcgacccgcugaaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagaggaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucgggcccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccggucggcggcgacgucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaggugggaucccgaggcccaguccgccgagggcgcaccaccggccgcacgagcgcacguguuaggacccgaaagauggugaaaccaucuaguagcugguucccuccgaaguuucccggauagcuggcgcucuccgcaguuuuauccgguggguaagaagccggcguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacggccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcauucaaacgagaacuuugaaggccgaaguggagaaggggcgauggccuccggcccucgcggagaugggcgccgcgaggcguccagugaaucucgcccgcagcaggucuccggugaacagccucuggcaauguagguaagggaagucgggaauccgauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggagaagacccuguugagcuugacucuagucuggcacggugaagagacaugagagguguagaauaagugggaggcggccgccggugaaauaccacuacucugaucguuuuuuccagugccagguggggaguuauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcgcgacgucgcuuuuugaugaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggggaccgucgugagacagguucccuacugaugguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguggugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauaagcgccgcggagccucgguuggccucggauagccgguccccgggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu ........................<<<<<<...............>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<<...<<<<<<<<<<.>>>>>>.>>>>.....>>>>>..<<<<<<<<<<...<<<<<<<<.<<.....<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>.>>>>>>>>>>..>>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<<.>>>>>>..>>>..................................<<....>>...............<<<<....>>>>................................<<<<<<<<..<<<......<<<<<<<<.<<<.....<<<<<<<.>>>>>>>......>>>.>>>.>>>>>..<<<<<<<<<<<<<<<<<<<<<<<<...<<..<<<.<<.<<<<......<<<<<<..>>>>>>.......>>>>>>.>>>........>>>>>>..>>>>>>>>>>>>>>.>>>>>>....>>>...>>>>>>>>..<<<<.<....>.>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>....<<<<<...<<<..<<.........>>..>>>....>>>>>.<<.>>....>>>>>>>>>>>>>..<<.<...<<<<<<...>>>>>>......>.>>..<<<<<<......<<<.>>>..<<.<<<<<<<...<<<.<<<<<<<<...>>>>>>...<<..>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.....<.<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>.>.>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<.............<<..>>..........>>>>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.<<<<<<.......>>>>>>.<<<<....<<<<...<<<<...........>>>>..<<<<<...<<<<<<<....>>>>>>>......>>.>>><<......>>.>>>><<<.....>>>..>>>>...<<<<<<.<<<<<<<<..<<<<<<.>>>>>>.>>>.>>>>>>>>>>>......>>....>>...<<<<<<........>>>>>>....<<<<.<<<<......<<<<<<.<<<<<<.<<<<<.<<<<<<<<<...<<<<<<<<<<.<<<<..........<<<<<..<<<.>>>............>>>>>.>>>>.>>.>>>>>>>>..>>>>>>>>>..>>>>>...<<<<<<<..<<<.........>>>>>>>>>>........>>>>>.>.>>>>>>.............<<<<<<...<..>...>>>>>>.......((...<<<<<<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.....))..>>>.....>>>>>....>>>>>>..<<<<<<<....>>>.>>>>>>>>.>>>>..<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<.<<.<<<<<<<....>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.<<<<<<<.<<..<<<<....<<<........<<<<<.<<<<>>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>..............>>>>..>>>>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<....<<<<<......>>>>>...>>>>....>>....>>>>.>>>.>>..>>>>>.. ........................(((((......[..........)))).).........((....))...((((......((.....)).....))))...((((...(((...((((((((((.)))))).)))).....)))....((((((((((...((((((((.((.....((((((((..({((((......)))))....[[(...).(((....}]])))...).))))))).))))))))))..))))))))))..)....(((((((....]...))))))).....((((((.))))))..)))..................................((....))............(..((((....))))............)...................((((((((..((((.....((((((((.(((.....(((((((.)))))))......))).))).)))))..((((((((((((((((((((((((...((..(((.((.((((......((((((())))))).......)))))).)))........))))))..)))))))))))))).))))))..).)))...))))))))..((((........))))((((((..(.(((((((((((((..(((..((((..........)))..)..)))....(((((...(((..(((.......)))..)))....))))).((.))....)))))))))))))..((.(...((((((...))))))......).))).((((((....(.(((.))).)((.(((((((...(((.((((((((...))))))...((()))....))))))))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.(((((......(....{.....(((.((((((((((.....<.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((.............((()))..........)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.((((((.......)))))).((((....((((...((((...........))))..(((((...(((((((....)))))))......)).)))((......)).))))(((.....)))..))))...((((((.((((((((..((((((.)))))).))).)))))))))))......))....)).[.((((((......].))))))....((((.((((.(....((((((.((((((.(((((.(((((((((...((((((((((.((((.......[..(((((..(((.)))..........].))))).)))).)).))))))))..)))))))))..)))))....((((((..(((.........))))))))).........))))).).))))))....).[}.....((((((...(())...)))))).......[[...(((((((((((..(.(.(((((......)))))...).).(((.....]]..))).....))))).]..))))))..(((((((....))).)))))))).))))..((((((.(..(((..(.(((((......(....).....))))).)((((....((((.((.(((((((....)))))..)).))...))))...)))).((((...((((.....>.......))))...))))..)))...).)))))).(((((((.((..((((.(..(((........(((((.(((()))).))))).......)))...(((..((((....((((.(((((((......)))))))))))...))))..)))...........)..))))..)))))))))(((((.(..(.......)..)....((.(((((((.((.....((((.(..((.((......)).))..)))))....))....)))).))).))..))))).. Human nucleolar pre-60S ribosomal subunit (State D1); 28S rRNA 8fkw L1 152 2.5 RF00002,RF02540 URS0000005270_9606 37410842 0003735 0005840 9606 acucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguucccggggcuacgccugucugagcgucgcuu .......................................<<<<<<<<<....>>>>.....<.<<<......>>.............>>>..>...>>>....<<....>><<<<<<<<<..>>>>>>>>>..................... .......................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))(((((((((..)))))))))..................... Human nucleolar pre-60S ribosomal subunit (State D2); 5.8S rRNA 8fkw L3 2277 2.5 RF02543 URS000075EC78_9606 37410842 0003735 0005840 9606 gcgaccucagaucagacguggcgacccgcugaaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagaggaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucgggcccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgccgcgcucuccggccgggccaggccacggagcgcacggggucggcggcgacgucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaggugggaucccgaggcccgccgagggcgcaccaccggcccgucucgcccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaaaccaucuaguagcugguucccuccgaaguuucccggauagcuggcgcucuccgcaguuuuauccgguggguaagaagcccggcucgagccgggcguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcauucaaacgagaacuuugaaggccgaaguggagaaggggcgauggccuccggcccucgcggagaugggcgccgcgaggcguccagugaaucucgcccgcagcaggucuccggugaacagccucuggcaauguagguaagggaagucgggaauccgauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggagaagacccuguugagcuugacucuagucuggcacggugaagagacaugagagguguagaauaagugggaggcggccgccggugaaauaccacuacucugaucguuuuuuccagugccagguggggaguuauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcgcgacgucgcuuuuugaugaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggggaccgucgugagacagguucccuacugaugguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguggugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauaagcgccgcggagccucgguuggccucggauagccgguccccgggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu ........................<<<<<<...............>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<<...<<<<<<<<<<.>>>>>>.>>>>.....>>>>>..<<<<<<<<<<...<<<<<<<<.<<.....<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>.>>>>>>>>>>..>>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<<.>>>>>>..>>>..................................<<....>>...............<<<<....>>>>................................<<<<<<<<.<<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<<..>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<.<<<<<<<<<<<<<<<...<<..<<<.<<.<<<<......<<<<<<..>>>>>>.......>>>>>>.>>>........>>>>>>..>>>>>>>>>>>..........<<<<<<.<..>.<<<<<<.>>>>.>>>>>>>>......>>.>>>>>...>>>>>..>>>>>>>>>..<<<<.<....>.>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>....<<<<<...<<<..<<<..>>>..>>>....>>>>>.<<<<<<<<<.<<..>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<...<<<<<<...>>>>>>......>.>>..<<<<<<......<<<.>>>..<<.<<<<<<<...<<<.<<<<<<<<...>>>>>>...<<<<<<<<..>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.....<.<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>.>.>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<...........>>>>>>>>>....>>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.<<<<<<.......>>>>>>.<<<<....<<<<...<<<<...........>>>>..<<<<<...<<<<<<<....>>>>>>>......>>.>>><<......>>.>>>><<<.....>>>..>>>>...<<<<<<.<<<<<<<<..<<<<<<.>>>>>>.>>>.>>>>>>>>>>>......>>....>>...<<<<<<........>>>>>>....<<<<.<<<<......<<<<<<.<<<<<<.<<<<<.<<<<<<<<<...<<<<<<<<<<.<<<<..........<<<<<..<<<.>>>............>>>>>.>>>>.>>.>>>>>>>>..>>>>>>>>>..>>>>>...<<<<<<<..<<<.........>>>>>>>>>>........>>>>>.>.>>>>>>.............<<<<<<...<..>...>>>>>>.......((...<<<<<<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.....))..>>>.....>>>>>....>>>>>>..<<<<<<<....>>>.>>>>>>>>.>>>>..<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<.<<.<<<<<<<....>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.<<<<<<<.<<..<<<<....<<<........<<<<<.<<<<>>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>..............>>>>..>>>>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<....<<<<<......>>>>>...>>>>....>>....>>>>.>>>.>>..>>>>>.. ........................(((((......[..........)))).).........((....))...((((......((.....)).....))))...((((...(((...((((((((((.)))))).)))).....)))....((((((((((...((((((((.((.....((((((((..({((((......)))))....[[(...).(((....}]])))...).))))))).))))))))))..))))))))))..)....(((((((....]...))))))).....((((((.))))))..)))..................................((....))............(..((((....))))............)...................((((((((..(((.((...((((((((.(((.....((((((((((()))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((.((.((((......((((((())))))).......)))))).)))........))))))..)))))))))))..........((((((.(()).((((((.)))).)))))))).....))).)))))...)))))...))))))))..((((........))))((((((..(.(((((((((((((..(((..((((..........)))..)..)))....(((((...(((..(((..)))..)))....))))).(((((((((.((()))))))))).))....)))))))))))))..((.(...((((((...))))))......).))).((((((....(.(((.))).)((.(((((((...(((.((((((((...))))))...((((((((()))))))))....))))))))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.(((((......(....{.....(((.((((((((((.....<.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((...........)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.((((((.......)))))).((((....((((...((((...........))))..(((((...(((((((....)))))))......)).)))((......)).))))(((.....)))..))))...((((((.((((((((..((((((.)))))).))).)))))))))))......))....)).[.((((((......].))))))....((((.((((.(....((((((.((((((.(((((.(((((((((...((((((((((.((((.......[..(((((..(((.)))..........].))))).)))).)).))))))))..)))))))))..)))))....((((((..(((.........))))))))).........))))).).))))))....).[}.....((((((...(())...)))))).......[[...(((((((((((..(.(.(((((......)))))...).).(((.....]]..))).....))))).]..))))))..(((((((....))).)))))))).))))..((((((.(..(((..(.(((((......(....).....))))).)((((....((((.((.(((((((....)))))..)).))...))))...)))).((((...((((.....>.......))))...))))..)))...).)))))).(((((((.((..((((.(..(((........(((((.(((()))).))))).......)))...(((..((((....((((.(((((((......)))))))))))...))))..)))...........)..))))..)))))))))(((((.(..(.......)..)....((.(((((((.((.....((((.(..((.((......)).))..)))))....))....)))).))).))..))))).. Human nucleolar pre-60S ribosomal subunit (State D2); 28S rRNA 8fkx L1 152 2.59 RF00002,RF02540 URS0000005270_9606 37410842 0003735 0005840 9606 acucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguucccggggcuacgccugucugagcgucgcuu .......................................<<<<<<<<<....>>>>.....<.<<<......>>.............>>>..>...>>>....<<....>><<<<<<<<<..>>>>>>>>>..................... .......................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))(((((((((..)))))))))..................... Human nucleolar pre-60S ribosomal subunit (State E); 5.8S rRNA 8fkx L3 2250 2.59 RF02543 URS000075EC78_9606 37410842 0003735 0005840 9606 gcgaccucagaucagacguggcgacccgcugaaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagaggaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucgggcccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgccgcgcucuccggccgggccaggccacggagcgcacggggucggcggcgacgucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaggugggaucccgaggcccgccgagggcgcaccaccggcccgucucgcccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccgguauaggggcgaaagacuaaccaucuaguagcugguucccuccgaaguuucccggauagcuggcgcucuccgcaguuuuauccgguggguaagaagcccggcucgagccgggcguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcauucaaacgagaacuuugaaggccgaggggcgauggccuccggcccucgcggagagugaaucucgcuggcaauguagguaagggaagucgggaauccgauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggagaagacccuguugagcuugacucuagucuggcacggugaagagacaugagagguguagaauaagugggaggcggccgccggugaaauaccacuacucugaucguuuuuuccagugccagguggggaguuauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcgcgacgucgcuuuuugaugaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggggaccgucgugagacagguuagucccuacugaugguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguggugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauaagcgccgcggagccucgguuggccucggauagccgguccccgggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu ........................<<<<<<...............>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<<...<<<<<<<<<<.>>>>>>.>>>>.....>>>>>..<<<<<<<<<<...<<<<<<<<.<<.....<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>.>>>>>>>>>>..>>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<<.>>>>>>..>>>..................................<<....>>...............<<<<....>>>>................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<<..>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<.<<<<<<<<<<<<<<<...<<..<<<.<<.<<<<......<<<<<<..>>>>>>.......>>>>>>.>>>........>>>>>>..>>>>>>>>>>>..........<<<<<<.<..>.<<<<<<.>>>>.>>>>>>>>......>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>....<<<<<...<<<..<<<..>>>..>>>....>>>>>.<<<<<<<<<.<<..>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<...<<<<<<...<<<<<<..>>>>>><<.<....>.>>.>>>>>>......>.>>..<<<<<<......<<<.>>>..<<.<<<<<<<...<<<.<<<<<<<<...>>>>>>...<<<<<<<<..>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.....<.<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>.>.>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<...........>>>>>>>>>....>>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.<<<<<<.......>>>>>>.<<<<..<<<<...........>>>>..<<<<<.......>>.>>>>>>>...<<<<<<.<<<<<<<<..<<<<<<.>>>>>>.>>>.>>>>>>>>>>>......>>....>>...<<<<<<........>>>>>>....<<<<.<<<<......<<<<<<.<<<<<<.<<<<<.<<<<<<<<<...<<<<<<<<<<.<<<<..........<<<<<..<<<.>>>............>>>>>.>>>>.>>.>>>>>>>>..>>>>>>>>>..>>>>>...<<<<<<<..<<<.........>>>>>>>>>>........>>>>>.>.>>>>>>.............<<<<<<...<..>...>>>>>>.......((...<<<<<<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.....))..>>>.....>>>>>....>>>>>>..<<<<<<<....>>>.>>>>...>>>>.>>>>..<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<.<<.<<<<<<<....>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.<<<<<<<.<<..<<<<....<<<........<<<<<.<<<<>>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>..............>>>>..>>>>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<....<<<<<......>>>>>...>>>>....>>....>>>>.>>>.>>..>>>>>.. ........................(((((......[..........)))).).........((....))...((((......((.....)).....))))...((((...(((...((((((((((.)))))).)))).....)))....((((((((((...((((((((.((.....((((((((..({((((......)))))....[[(...).(((....}]])))...).))))))).))))))))))..))))))))))..)....(((((((....]...))))))).....((((((.))))))..)))..................................((....))............(..((((....))))............)...................((((((((..(((.((...((((((((.(((.....((((((((((()))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((.((.((((......((((((())))))).......)))))).)))........))))))..)))))))))))..........((((((.(()).((((((.)))).)))))))).....))).)))))...)))))...))))))))..((((........))))((((((..(.(((((((((((((..(((..((((..........)))..)..)))....(((((...(((..(((..)))..)))....))))).(((((((((.((()))))))))).))....)))))))))))))..((.(...((((((...((((((()))))))((.(....).)).))))))......).))).((((((....(.(((.))).)((.(((((((...(((.((((((((...))))))...((((((((()))))))))....))))))))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.(((((......(....{.....(((.((((((((((.....<.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((...........)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.((((((.......)))))).((((..((((...........))))..(((((.......)).)))))))...((((((.((((((((..((((((.)))))).))).)))))))))))......))....)).[.((((((......].))))))....((((.((((.(....((((((.((((((.(((((.(((((((((...((((((((((.((((.......[..(((((..(((.)))..........].))))).)))).)).))))))))..)))))))))..)))))....((((((..(((.........))))))))).........))))).).))))))....).[}.....((((((...(())...)))))).......[[...(((((((((((..(.(.(((((......)))))...).).(((.....]]..))).....))))).]..))))))..(((((((....))).))))...)))).))))..((((((.(..(((..(.(((((......(....).....))))).)((((....((((.((.(((((((....)))))..)).))...))))...)))).((((...((((.....>.......))))...))))..)))...).)))))).(((((((.((..((((.(..(((........(((((.(((()))).))))).......)))...(((..((((....((((.(((((((......)))))))))))...))))..)))...........)..))))..)))))))))(((((.(..(.......)..)....((.(((((((.((.....((((.(..((.((......)).))..)))))....))....)))).))).))..))))).. Human nucleolar pre-60S ribosomal subunit (State E); 28S rRNA 8fky L1 155 2.67 RF00002,RF02540 URS0000005270_9606 37410842 0003735 0005840 9606 acucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcuu .......................................<<<<<<<<<....>>>>.....<.<<<......>>.............>>>..>...>>>....<<....>><<<<<<<<<.....>>>>>>>>>..................... .......................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))(((((((((.....)))))))))..................... Human nucleolar pre-60S ribosomal subunit (State F); 5.8S rRNA 8fky L3 2585 2.67 RF02543 URS0002681434_9606 37410842 0003735 0005840 9606 gcgaccucagaucagacguggcgacccgcugaaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucgggcccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgccgcgcucuccggccgggccaggccacggagcgcacggggucggcggcgacgucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaggugggaucccgaggcccgccgagggcgcaccaccggcccgucucgcccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugcaagccagaggaaacucugguggguauaggggcgaaagacuaaccaucuaguagcugguucccuccgaaguuucccggauagcuggcgcucucgcgcaguuuuauccgguggguaagaagcccggcucgagccgggcguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcuucaaacgagaacuuugaaggccgaaguggagaaggguuccauguacaugggucagucgguccuagggacgggcgauggccuccggcccgccggggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcaauccgggggagaggguguaaaucucgcgccgggccguacccuccaaggugaacagccucuggcaauguagguaagggaagucgggaauccgauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggagaagacccuguugagcuugacucuagucuggcacggugaagagacaugagagguguagaauaagugggaggcggccgccggugaaauaccacuacucugaucguuuuuuccagugccagguggggaguuauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcgcgacgucgcuuuuugaugaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggggaccgucgugagacagguuagucccuacugaugguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguggugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacagcgccgcggagccucgguuggccucggauagccgguccccgggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu ........................<<<<<<...............>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<<...<<<<<<<<<<.>>>>>>.>>>>.....>>>>>..<<<<<<<<<<...<<<<<<<<.<<.....<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>.>>>>>>>>>>..>>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<<.>>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<<..>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<.<<<<<<<<<<<<<<<...<<..<<<.<<.<<<<......<<<<<<..>>>>>>.......>>>>>>.>>>........>>>>>>..>>>>>>>>>>>..........<<<<<<.<..>.<<<<<<.>>>>.>>>>>>>>......>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>....<<<<<...<<<..<<<..>>>..>>>....>>>>>.<<<<<<<<<.<<..>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<...<<<<<<...<<<<<...<<<<<<<....>>>>>>>...>>>>><<.<....>.>>.>>>>>>......>.>>..<<<<<<......<<<.>>>..<<.<<<<<<<....<<<.<<<<<<<<...>>>>>>...<<<<<<<<..>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.....<.<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>.>.>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<...........>>>>>>>>>....>>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<<<<<<<.......>>>>>>.<<<.....<<<<..<<...<<<<<..>>>>>....((<<<<<...<<...<<<<...........>>>>.>>..>...<<<<<........>>>>>))<<<<....<<<<<...<<<<<<<....>>>>>>>...<<<....>>>......<<<<<<<...<<<<<<<<<<<..<<<<<<<<<<.......>>>>>>.....<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>......<<<<<<<.......>>>>>>>>>>>....>>>>>>>>>>>..>>>>>>>.............>>.>>>.>>>>>>>>..>>>>>>.<<<<.....>>>>..>>>...<<<<<<.<<<<<<<<..<<<<<<.>>>>>>.>>>.>>>>>>>>>>>......>>....>>...<<<<<<........>>>>>>....<<<<.<<<<......<<<<<<.<<<<<<.<<<<<.<<<<<<<<<...<<<<<<<<<<.<<<<..........<<<<<..<<<.>>>............>>>>>.>>>>.>>.>>>>>>>>..>>>>>>>>>..>>>>>...<<<<<<<..<<<.........>>>>>>>>>>........>>>>>.>.>>>>>>.............<<<<<<...<..>...>>>>>>.......((...<<<<<<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.....))..>>>.....>>>>>....>>>>>>..<<<<<<<....>>>.>>>>...>>>>.>>>>..<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<.<<.<<<<<<<....>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>..<<<<<<<.<<..<<<<....<<<........<<<<<.<<<<>>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>..............>>>>..>>>>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<.<..<<<<<......>>>>>..>>>>>....>>....>>>>.>>>.>>..>>>>>.. ........................(((((......[..........)))).).........((....))...((((......((.....)).....))))...((((...(((...((((((((((.)))))).)))).....)))....((((((((((...((((((((.((.....((((((((..({((((......)))))....[[(...).(((....}]])))...).))))))).))))))))))..))))))))))..)....(((((((....]...))))))).....((((((.))))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....((((((((((()))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((.((.((((......((((((())))))).......)))))).)))........))))))..)))))))))))..........((((((.(()).((((((.)))).)))))))).....))).)))))...)))))...))))))))..((((........))))((((((..(.(((((((((((((..(((..((((..........)))..)..)))....(((((...(((..(((..)))..)))....))))).(((((((((.((()))))))))).))....)))))))))))))..((.(...((((((...((((((..(((((((....)))))))..))))))((.(....).)).))))))......).))).((((((....(.(((.))).)((.(((((((....(((.((((((((...))))))...((((((((()))))))))....))))))))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.(((((......(....{.....(((.((((((((((.....<.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((...........)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((((((((.......)))))).(((.....((((..((...(((((())))))....[[(((.((..((..(((((...........))))))).))...(((((........)))))]]((((....(((((...(((((((....)))))))..((((....)))...(...((((((...((((((((((..((((((.((((.......)))))......((((.((((.((((.....(((.....))).....))))))))..))))......((((((((....).))))))))))).)...))))))))))..))))))...)).........)).))).)))).)))..)))))).((((.....))))..)))...((((((.((((((((..((((((.)))))).))).)))))))))))......))....)).[.((((((......].))))))....((((.((((.(....((((((.((((((.(((((.(((((((((...((((((((((.((((.......[..(((((..(((.)))..........].))))).)))).)).))))))))..)))))))))..)))))....((((((..(((.........))))))))).........))))).).))))))....).[}.....((((((...(())...)))))).......[[...(((((((((((..(.(.(((((......)))))...).).(((.....]]..))).....))))).]..))))))..(((((((....))).))))...)))).))))..((((((.(..(((..(.(((((......(....).....))))).)((((....((((.((.(((((((....)))))..)).))...))))...)))).((((...((((.....>.......))))...))))..)))...).))))))..(((((((.((..((((.(..(((........(((((.(((()))).))))).......)))...(((..((((....((((.(((((((......)))))))))))...))))..)))...........)..))))..)))))))))(((((.(..(.......)..)....((.(((((((.((.....((((.(..((.((......)).))..)))))....))....)))).))).))..))))).. Human nucleolar pre-60S ribosomal subunit (State F); 28S rRNA 8fkz L1 154 3.04 RF00002,RF02540 URS0000005270_9606 37410842 0003735 0005840 9606 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccgggccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<<<<....>>>>.....<.<<<......>>.............>>>..>...>>>....<<....>><<<<<<<<<...>>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))(((((((((...))))))))).................... Human nucleolar pre-60S ribosomal subunit (State G); 5.8S rRNA 8fkz L3 2833 3.04 RF02543 URS000075EC78_9606 37410842 0003735 0005840 9606 gcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcgggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggccggccgugucggcggcccggcggaucugggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucgggcccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagucgccgcgcucuccccccggggggccgggccaccccucccacggcgcgcgccgucgggcccggggggccacgcgcgcgucccccgaagagggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccgucaaacacggaccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccgcggccgaggugggaucccgaggccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcguccgaccuggguauaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucuccgcaguuuuauccggggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagugacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccggcccucgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaaggggcucuaagggcugggucggucgggcuggggcgcgaagcggggucccguggaucgccccagccggccggcgccuagcagccgacuuagaacugcaucgcgaaggcccgggguguugacgcgauguugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagacccggugaggcggggggcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggcuucugaccuuuuggguuuuaagcaggagggcuuguggcggccaagcgagcgacgucgcuuuuugcggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggcuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauagcgccgcggagccucgguuggccucggauagccgguccccgggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu ........................<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..[[[..<<<<<...<<<<<<<<<..>>>>>.>>>>.....>>>>>..<<<<<<<<<<...<<<<<<<<.<<<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>.>>>>>>>>>>..>>>>>>>>>>.......<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<......>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<<<<<<<<<<.<<<<<.<<...<<<<<.<<<.>>>>>>>>>>>>>>>>>>>...>>>>>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<<<<<<<<<<<<<<<<<...<<..<<<.<<.<<<<......<<<<<<..>>>>>>.......>>>>>>.>>>........>>>>>>..>>>>>>>>>>>...........<<<<<<.<<<<<..>>>>>.<<<<<<.<<<<.<<<<<<<<<..>>>>>>.>>>...>>>>>>>>.>>..<<<<<<<<<.......>>>>>>>.>>....>>>>>>.....>>>.>>>>>...>>>>>...>>>>>>>>..<<<<.....>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<..>>>>..<<<<<...<<<..<<<.>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<..>....>>>>>>>>>>>>>>>......>.>>..<<<<<<......<<<....>>>..<<.<<<<<<<...<<<.<<<<<<<<..>>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<...........>>>>>>>>>....>>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>.............<<<<...........>>>>....>>....>>>..<<<<<........>>>>>))<<<<....<<<<<..<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..{{{..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.<.<<<<<<<<<<<.<<<<<<<<.<<<<<<<<<....<<<<<..>>>>>....>>>>>>>>>>>>>>>>>......>>>>>..>>>>>>.>.<<<<<<<....<<<<.>>>>......>>>>>>>...>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[.<<<<<.....<<<<................<<<<<<<<<<.......>>>>>>>>>>..>>>>..>>>>>.((((((..(((..>>>>>>.))))))))).......<<<<<<...<<..>>...>>>>>>.....<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>>....]]]]].....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<.}}}..>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.<<<<<<.<<..<<<<....<<<........<<<<<.<<<<>>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>..............>>>>..>>>>>>>>.<<<<<.<.............>....<<.<<<<<<<.<<.....<<<<....<<<<<......>>>>>...>>>>....>>....>>>.>>>>.>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..((((((((((..))))).))))....))))....((((((((((...((((((((.((((((((((..({((((......)))))....[[(...).(((....}]])))...).))))))).))))))))))..))))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....((((((((((((((((((.(((((.((...(((((.(((.)))))))))))))))))))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((.((.((((......((((((())))))).......)))))).)))........))))))..)))))))))))...........((((((.(((((()))))).((((((.((((.(((((((((())))))).)))...)))))))).))..((((((((.........)))))).))....)))))).....))).)))))...)))))...))))))))..((((.....))))((((((..(.(((((((((((((..(((..((((..........)))..)..)))...((....))...((((()))))..(((((...(((..(((.)))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...).)))...(())..).)))))))))))))))......).))).((((((......(((....)))..((.(((((((...(((.((((((((..))))))...(((((((((.(......))))))))))....))))))))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.(((((......(..<.....(((.((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((...........)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...((....(((....)))...(.).......((((...........))))....))....))...(((((........)))))]]((((....(((((...(((((((....)))))))..((((....)))...(...((((((...(((((((((((((((((((((((..{{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((.(.(((((((((((.((((((((.(((((((((....(((((())))))....)))))))))))))))))......)))))..)))))).).(((((((....((((.))))......)))))))...)).)))))))..))))))....)).[..(((((......].)))))....(((((.(((((.....((((................(((((((((.........)))))))))..))))..))))).((((((..(((..]]]]]].))))))))).>.....((((((...((..))...)))))).....((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))))....))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}}.)))))..)).))...))))...)))).((((...((((.....}.......))))...))))..)))...).)))))).((((((.((..((((.(..(((........(((((.(((()))).))))).......)))...(((..((((....((((.(((((((......)))))))))))...))))..)))...........)..))))..)))))))).(((((.(..(.......)..)....((.(((((((.((.....((((.(..(((((......)))))..)))))....))....))).)))).))..))))).. Human nucleolar pre-60S ribosomal subunit (State G); 28S rRNA 8fl2 L1 154 2.67 RF00002 URS0000005270_9606 37410842 0003735 0005840 9606 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauuncaggacacauugaucaucgacacuucgaacgcacuugcggccccgggccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<<<<....>>>>.....<.<<<......>>.............>>>..>...>>>....<<....>><<<<<<<<<...>>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))(((((((((...))))))))).................... Human nuclear pre-60S ribosomal subunit (State I1); 5.8S rRNA 8fl2 L2 72 2.67 URS0002681439_9606 37410842 9606 ccgaucaaucgcccccggggugcgcggcugggggcucgcagggccccuccgucccccuaagcgcagacgaga .........<<<<<<..>>>.>>>.....<<<<<..<<.<<<<.>>>>.>>.>>>>>............... .........((((((()))).)))....((((((..((.((((.)))).)).)))))..)............ Human nuclear pre-60S ribosomal subunit (State I1); ITS2 rRNA 8fl2 L3 3495 2.67 RF02543 URS000075EC78_9606 37410842 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcgggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagngngaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggccggccgugucggcggcccggcggaucugggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucgggcccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagucgccgcgcucuccccccggggggccgggccaccccucccacggcgcgcgccgucgggcccggggggccacgcgcgcgucccccgaagagggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccnucuugnaacncggaccaaggagunuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccgcggccgaggugggaucccgaggcccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccnanagauggugancuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauagnggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucuccgcaguuuuauccgguaaagcgaaugauuagaggucuuggngccggaucncaaccuauucucggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcngaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagugacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaunuuggugguagunnnaaauauucaaacgagaacuuugaaggccgaaguggngaaggguuccaugngaacagnanuugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccggcccucgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccnuauccgcagcaggucuncaaggugaacngccucuggnauguuggaacaanguagguaagggaagucggcaagcnggauccguaacuucnggauaaggauuggcucuaagggcugggucggucgggcuggggcgcgaagcggggucccguggaucgccccagccggccggcgccuagcagccgacuuagaacuggugcggaccaggngaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgggguguugacgcgaugugauuucugccnagugcucugaaugucanagugangaaauucaaugaagcgcggnuaaacggcgggaguancuaugacucucuuaagguagcnaanugccucnucaugugangcgcaugaanggaugancgagnuucccacugunccuaccuacuauccagcgaaaccacngncaagggaacgggcuuggnggaaucagcggngaaagaagacccuguugagcuugacncuagucuggcacggugaagagacaugagagguguagaauaagugggaggcggccgccngugaaauaccanuacucugaucguuuuuucacugacccggugaggcggggggcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccagguggggaguuugguacaccugucaaacgguancgcaggnnuccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuugnacgaauacagaccgugaaagcggggccucacccuucugaccuuuuggguuuuaagcaggangaaguuaccacagngauaacuggcuuguggcggccaagcgagcgacgucgcuuuuugauccuungaugucggnucuuccuaucauugugaagcagaauucaccaagcguungaunnuucacccacuaauagggaacgugngcugggnuuagancgucgugagacagguuaguuuuacccuacugaugnuguguuguugccaugguanuccugcucaguacgagaggaaccgcagnuncanacauuugguguaunugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauagcgccgcggagccucgguuggccucggauagccgguccccgggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<<...<<<<<<<<<..>>>>>.>>>>.....>>>>>..<<<<<<<<<<...<<<<<<<<.<<<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>.>>>>>>>>>>..>>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<......>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<<<<<<<<<<.<<<<<.<<...<<<<<.<<<.>>>>>>>>>>>>>>>>>>>...>>>>>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<<<<<<<<<<<<<<<<<...<<..<<<.<<.<<<<......<<<<<<..>>>>>>.......>>>>>>.>>>........>>>>>>..>>>>>>>>>>>...........<<<<<<.<<<<<..>>>>>.<<<<<<.<<<<.<<<<<<<<<..>>>>>>.>>>...>>>>>>>>.>>..<<<<<<<<<.......>>>>>>>.>>....>>>>>>.....>>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<..>>>>..<<<<<...<<<..<<<..>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<......<<<....>>>..<<<<<<<<<<...<<<.<<<<<<<<............<<....<<<..<<<<<<.<.>.>>>>>>>>>..>>..>>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>>>>>>.>>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<...........>>>>>>>>>....>>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<....<<.....>>..>>>>>....((<<<<<<...<<....<<<....>>>.............<<<<...........>>>>....>>....>>>..<<<<<........>>>>>))<<<<....<<<<<..<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<...............<<<<<.....<..>......>>>>><<.<<<<<<<<<<<.<<<<<<<<.<<<<<<<<<....<<<<<..>>>>>....>>>>>>>>>>>>>>>>>......>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.>>>>......>>>>>>>.......<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>.............<<<<..<<<<<<>>>>>>.>>>>...........>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<........<<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<<<<<<.<<<<..........<<<<<..<<<.>>>............>>>>>.>>>>.>>.>>>>>>>>>>...<<<<<.....<<<<................<<<<<<<<<<.......>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>..<<.<<<<<<<.............>>>>>>>>>...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<..<<<<.[[..>>>>..>>>.<<<....>>>...))).]]<<<<<<<..<<<..)))))).>>>>>>>>>>.>>>>..>>>>>>>.............<<<<<<...<<..>>...>>>>>>.................<<<<.<<<<<<..<.<.<<<<<......>>>>>.>...>.<<<.........>>>.....>>>>>..>...>>>>......<<<<<<<....>>>.>>>>........>>>.>>>>>.....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<]]].>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.<<<<<<.<<..<<<<....<<<........<<<<<.<<<<>>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>..............>>>>..>>>>>>>>.<<<<<.<.............>....<<.<<<<<<<.<<.....<<<<.<..<<<<<......>>>>>..>>>>>....>>....>>>.>>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..((((((((((..))))).))))....))))....((((((((((...((((((((.((((((((((..({((((......)))))....[[(...).(((....}]])))...).))))))).))))))))))..))))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....((((((((((((((((((.(((((.((...(((((.(((.)))))))))))))))))))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((.((.((((......((((((())))))).......)))))).)))........))))))..)))))))))))...........((((((.(((((()))))).((((((.((((.(((((((((())))))).)))...)))))))).))..(((((((((.......))))))).))....)))))).....))).)))))...)))))...))))))))..((((........))))((((((..(.(((((((((((((..(((..((((..........)))..)..)))...((....))...((((()))))..(((((...(((..(((..)))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))).((((((......(((....)))..((.(((((((...(((.((((((((............(......((..((((((.(.).))))))))....)..))))))...(((((((((.(......))))))))))....))))))))))))..))..((((..(.((.....)).)..))))....(((......)))...(((((((...((([[[...(.(.(((((......(....<.....(((.((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((...........)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...(.....(((....)))...(.).......((((...........)))).....)....))...(((((........)))))]]((((....(((((...(((((((....)))))))..((((....)))...(...((((((...((((((((((((((((((((((...{{{...)))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).)))..)).....((......)).)))).((((.....))))..)))....(((......(.((((..((..(....(.......(((((....(.{..).....)))))((.(((((((((((.((((((((.(((((((((....(((((())))))....)))))))))))))))))......)))))..)))))).))(...).......(((((((((.].(...........)...(((((((....((((.))))......))))))).}.....(((..((((((.(...(......((.(....).))......).)))))..)))))(.(.(.........).).)..........(..((((..(((((()))))).)))).....).....)).))))))).)..)))..)))).)...)))))....)).[..((.((......].)).))....(((((..((((.......(((((.(((((...(((((.(((((((((.((((((((((((.((((.......[..(((((..(((.)))..........].))))).)))).)).))))))))))...(((((.....((((................(((((((((.........)))))))))..))))..)))))....)))))))))..)))))..((..(((((((...........))))))).))..((((((((.(.((((((.......))))))...).((....[[))....))))))))(..((....((.{{..))....)).)(((....)))...]]..}}(((((((..(((..]]]]]].))))))))))..)))..))))))).......>.....((((.(...((..))...).)))).................((((.((((((..(.(.(.(((......))).)...).)..((.(.....).))......)))))..)...)))).......((((((....))).)))...>..)..))).))))).....(.((.(.(..(((..(.(((((......(....).....))))).)(((.....((((....((.(((((((}}}.)))))..)).))...))))....))).((((...((((.....}.......))))...))))..)))...).).)).).((((((.((..((((.(..(((........(((((.(((()))).))))).......)))...(((..((((....((((.(((((((......)))))))))))...))))..)))...........)..))))..)))))))).(((((....(.......).......((.(((((((.((.....(.((.(..(((((......)))))..))).)....))....))).)))).))..))))).. Human nuclear pre-60S ribosomal subunit (State I1); 28S rRNA 8fl3 L1 154 2.53 RF00002 URS0000005270_9606 37410842 0003735 0005840 9606 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauuncaggacacauugaucaucgacacuucgaacgcacuugcggccccgggccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<<<<....>>>>.....<.<<<......>>.............>>>..>...>>>....<<....>><<<<<<<<<...>>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))(((((((((...))))))))).................... Human nuclear pre-60S ribosomal subunit (State I2); 5.8S rRNA 8fl3 L3 3494 2.53 RF02543 URS000075EC78_9606 37410842 0003735 0005840 9606 gcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcgggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagngngaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggccggccgugucggcggcccggcggaucugggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucgggcccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagucgccgcgcucuccccccggggggccgggccaccccucccacggcgcgcgccgucgggcccggggggccacgcgcgcgucccccgaagagggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccnucuugnaacncggaccaaggagunuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccgcggccgaggugggaucccgaggcccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccnanagauggugancuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauagnggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucuccgcaguuuuauccgguaaagcgaaugauuagaggucuuggngccggaucncaaccuauucucggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcngaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagugacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaunuuggugguagunnnaaauauucaaacgagaacuuugaaggccgaaguggngaaggguuccaugngaacagnanuugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccggcccucgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccnuauccgcagcaggucuncaaggugaacngccucuggnauguuggaacaanguagguaagggaagucggcaagcnggauccguaacuucnggauaaggauuggcucuaagggcugggucggucgggcuggggcgcgaagcggggucccguggaucgccccagccggccggcgccuagcagccgacuuagaacuggugcggaccaggngaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgggguguugacgcgaugugauuucugccnagugcucugaaugucanagugangaaauucaaugaagcgcggnuaaacggcgggaguancuaugacucucuuaagguagcnaanugccucnucaugugangcgcaugaanggaugancgagnuucccacugunccuaccuacuauccagcgaaaccacngncaagggaacgggcuuggnggaaucagcggngaaagaagacccuguugagcuugacncuagucuggcacggugaagagacaugagagguguagaauaagugggaggcggccgccngugaaauaccanuacucugaucguuuuuucacugacccggugaggcggggggcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccagguggggaguuugguacaccugucaaacgguancgcaggnnuccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuugnacgaauacagaccgugaaagcggggccucacccuucugaccuuuuggguuuuaagcaggangaaguuaccacagngauaacuggcuuguggcggccaagcgagcgacgucgcuuuuugauccuungaugucggnucuuccuaucauugugaagcagaauucaccaagcguungaunnuucacccacuaauagggaacgugngcugggnuuagancgucgugagacagguuaguuuuacccuacugaugnuguguuguugccaugguanuccugcucaguacgagaggaaccgcagnuncanacauuugguguaunugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauagcgccgcggagccucgguuggccucggauagccgguccccgggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu ........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<<...<<<<<<<<<..>>>>>.>>>>.....>>>>>..<<<<<<<<<<...<<<<<<<<.<<<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>.>>>>>>>>>>..>>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<......>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<<<<<<<<<<.<<<<<.<<...<<<<<.<<<.>>>>>>>>>>>>>>>>>>>...>>>>>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<<<<<<<<<<<<<<<<<...<<..<<<.<<.<<<<......<<<<<<..>>>>>>.......>>>>>>.>>>........>>>>>>..>>>>>>>>>>>...........<<<<<<.<<<<<..>>>>>.<<<<<<.<<<<.<<<<<<<<<..>>>>>>.>>>...>>>>>>>>.>>..<<<<<<<<<.......>>>>>>>.>>....>>>>>>.....>>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<..>>>>..<<<<<...<<<..<<<..>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<......<<<....>>>..<<.<<<<<<<...<<<.<<<<<<<<............<<....<<<..<<<<<<.<.>.>>>>>>>>>..>>..>>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<...........>>>>>>>>>....>>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<....<<.....>>..>>>>>....((<<<<<<...<<....<<<....>>>.............<<<<...........>>>>....>>....>>>..<<<<<........>>>>>))<<<<....<<<<<..<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<...............<<<<<.....<..>......>>>>><<.<<<<<<<<<<<.<<<<<<<<.<<<<<<<<<....<<<<<..>>>>>....>>>>>>>>>>>>>>>>>......>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.>>>>......>>>>>>>.......<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>.............<<<<..<<<<<<>>>>>>.>>>>...........>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<........<<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<<<<<<.<<<<..........<<<<<..<<<.>>>............>>>>>.>>>>.>>.>>>>>>>>>>...<<<<<.....<<<<................<<<<<<<<<<.......>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>..<<.<<<<<<<.............>>>>>>>>>...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<..<<<<.[[..>>>>..>>>.<<<....>>>...))).]]<<<<<<<..<<<..)))))).>>>>>>>>>>.>>>>..>>>>>>>.............<<<<<<...<<..>>...>>>>>>.................<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>>......<<<<<<<....>>>.>>>>........>>>.>>>>>.....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<]]].>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.<<<<<<.<<..<<<<....<<<........<<<<<.<<<<>>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>..............>>>>..>>>>>>>>.<<<<<.<.............>....<<.<<<<<<<.<<.....<<<<.<..<<<<<......>>>>>..>>>>>....>>....>>>.>>>>.>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..((((((((((..))))).))))....))))....((((((((((...((((((((.((((((((((..({((((......)))))....[[(...).(((....}]])))...).))))))).))))))))))..))))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....((((((((((((((((((.(((((.((...(((((.(((.)))))))))))))))))))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((.((.((((......((((((())))))).......)))))).)))........))))))..)))))))))))...........((((((.(((((()))))).((((((.((((.(((((((((())))))).)))...)))))))).))..((((((((.........)))))).))....)))))).....))).)))))...)))))...))))))))..((((........))))((((((..(.(((((((((((((..(((..((((..........)))..)..)))...((....))...((((()))))..(((((...(((..(((..)))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))).((((((......(((....)))..((.(((((((...(((.((((((((............(......((..((((((.(.).))))))))....)..))))))...(((((((((.(......))))))))))....))))))))))))..))..((((..(.((.....)).)..))))....(((......)))...(((((((...((([[[...(.(.(((((......(....<.....(((.((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((...........)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...(.....(((....)))...(.).......((((...........)))).....)....))...(((((........)))))]]((((....(((((...(((((((....)))))))..((((....)))...(...((((((...((((((((((((((((((((((...{{{...)))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).)))..)).....((......)).)))).((((.....))))..)))....(((......(.((((..((..(....(.......(((((....(.{..).....)))))((.(((((((((((.((((((((.(((((((((....(((((())))))....)))))))))))))))))......)))))..)))))).))(...).......(((((((((.].(...........)...(((((((....((((.))))......))))))).}.....(((..((((((.(...(......((.(....).))......).)))))..)))))(.(.(.........).).)..........(..((((..(((((()))))).)))).....).....)).))))))).)..)))..)))).)...)))))....)).[..((.((......].)).))....(((((..((((.......(((((.(((((...(((((.(((((((((.((((((((((((.((((.......[..(((((..(((.)))..........].))))).)))).)).))))))))))...(((((.....((((................(((((((((.........)))))))))..))))..)))))....)))))))))..)))))..((..(((((((...........))))))).))..((((((((.(.((((((.......))))))...).((....[[))....))))))))(..((....((.{{..))....)).)(((....)))...]]..}}(((((((..(((..]]]]]].))))))))))..)))..))))))).......>.....((((.(...((..))...).)))).................((((.((((((..(.(.(.(((......))).)...).)..((.(.....).))......)))))..)...)))).......((((((....))).)))...>..)..))).))))).....(.((.(.(..(((..(.(((((......(....).....))))).)(((.....((((....((.(((((((}}}.)))))..)).))...))))....))).((((...((((.....}.......))))...))))..)))...).).)).).((((((.((..((((.(..(((........(((((.(((()))).))))).......)))...(((..((((....((((.(((((((......)))))))))))...))))..)))...........)..))))..)))))))).(((((....(.......).......((.(((((((.((.....(.((.(..(((((......)))))..))).)....))....))).)))).))..))))).. Human nuclear pre-60S ribosomal subunit (State I2); 28S rRNA 8fl4 L1 154 2.89 RF00002 URS0000005270_9606 37410842 0003735 0005840 9606 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauuncaggacacauugaucaucgacacuucgaacgcacuugcggccccgggccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<.<<.....>>>.....(.<<<......>>.............>>>..)...>>>....<<....>><<<<<<<<<...>>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))(((((((((...))))))))).................... Human nuclear pre-60S ribosomal subunit (State I3); 5.8S rRNA 8fl4 L3 3486 2.89 RF02543 URS000075EC78_9606 37410842 0003735 0005840 9606 gcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcgggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagngngaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggccggccgugucggcggcccggcggaucugggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucgggcccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagucgccgcgcucuccccccggggggccgggccaccccucccacggcgcgcgccgucgggcccggggggccacgcgcgcgucccccgaagagggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccnucuugnaacncggaccaaggagunuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccgcggccgaggugggaucccgaggcccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccnanagauggugancuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauagnggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucuccgcaguuuuauccgguaaagcgaaugauuagaggucuuggngccggaucncaaccuauucucggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcngaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagugacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaunuuggugguagunnnaaauauucaaacgagaacuuugaaggccgaaguggngaaggguuccaugngaacagnanuugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgaugcccucgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccnuauccgcagcaggucuncaaggugaacngccucuggnauguuggaacaanguagguaagggaagucggcaagcnggauccguaacuucnggauaaggauuggcucuaagggcugggucggucgggcuggggcgcgaagcggggucccguggaucgccccagccggccggcgccuagcagccgacuuagaacuggugcggaccaggngaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgggguguugacgcgaugugauuucugccnagugcucugaaugucanagugangaaauucaaugaagcgcggnuaaacggcgggaguancuaugacucucuuaagguagcnaanugccucnucaugugangcgcaugaanggaugancgagnuucccacugunccuaccuacuauccagcgaaaccacngncaagggaacgggcuuggnggaaucagcggngaaagaagacccuguugagcuugacncuagucuggcacggugaagagacaugagagguguagaauaagugggaggcggccgccngugaaauaccanuacucugaucguuuuuucacugacccggugaggcggggggcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccagguggggaguuugguacaccugucaaacgguancgcaggnnuccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuugnacgaauacagaccgugaaagcggggccucacccuucugaccuuuuggguuuuaagcaggangaaguuaccacagngauaacuggcuuguggcggccaagcgagcgacgucgcuuuuugauccuungaugucggnucuuccuaucauugugaagcagaauucaccaagcguungaunnuucacccacuaauagggaacgugngcugggnuuagancgucgugagacagguuaguuuuacccuacugaugnuguguuguugccaugguanuccugcucaguacgagaggaaccgcagnuncanacauuugguguaunugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauagcgccgcggagccucgguuggccucggauagccgguccccgggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu ........................<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<...<<<<...<<<<<<<<<..>>>>>.>>>>.....>>>>...<<<<<<<<<<...<<<<<<<<.<<<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>.>>>>>>>>>>..>>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<......>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<<<<<<<<<<.<<<<<.<<...<<<<<.<<...>>>>>>>>>>>>>>>>>>...>>>>>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<<<<<<<<<<<<<<<<<...<<..<<<.<<.<<<<......<<<<<<..>>>>>>.......>>>>>>.>>>........>>>>>>..>>>>>>>>>>>...........<<<<<<.<<<<<..>>>>>.<<<<<<.<<<<.<<<<<<<<<..>>>>>>.>>>...>>>>>>>>.>>..<<<<<<<<<.......>>>>>>>.>>....>>>>>>.....>>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<..>>>>..<<<<<...<<<..<<<..>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<......<<<....>>>..<<<<<<<<<<...<<<.<<<<<<<<............<<....<<<..<<<<<<.<.>.>>>>>>>>>..>>..>>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>>>>>>.>>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<...........>>>>>>>>>....>>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<....<<.....>>..>>>>>....((<<<<<<...<<....<<<....>>>.............<<<<...>>>>....>>....>>>..<<<<<........>>>>>))<<<<.....<<<<..<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>..>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<...............<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<.<<<<<<<<.<<<<<<<<<....<<<<<..>>>>>....>>>>>>>>>>>>>>>>>......>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.>>>>......>>>>>>>.......<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>.............<<<<..<<<<<<>>>>>>.>>>>...........>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<........<<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<<<<<<.<<<<..........<<<<<..<<<.>>>............>>>>>.>>>>.>>.>>>>>>>>>>...<<<<<.....<<<<................<<<<<<<<<<.......>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>..<<.<<<<<<<.............>>>>>>>>>...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<..<<<<.[[..>>>>..>>>.<<<....>>>...))).]]<<<<<<<..<<<..)))))).>>>>>>>>>>.>>>>..>>>>>>>.............<<<<<<...<<..>>...>>>>>>.................<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>>......<<<<<<<....>>>.>>>>........>>>.>>>>>.....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<]]].>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.<<<<<<.<<..<<<<....<<<........<<<<<.<<<<>>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>..............>>>>..>>>>>>>>.<<<<<.<.............>....<<.<<<<<<<.<<.....<<<<....<<<<<......>>>>>...>>>>....>>....>>>.>>>>.>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..((((((((((..))))).))))....))))....((((((((((...((((((((.((((((((((..({((((......)))))....[[(...).(((....}]])))...).))))))).))))))))))..))))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....((((((((((((((((((.(((((.((...(((((.(((.)))))))))))))))))))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((.((.((((......((((((())))))).......)))))).)))........))))))..)))))))))))...........((((((.(((((()))))).((((((.((((.(((((((((())))))).)))...)))))))).))..(((((((((.......))))))).))....)))))).....))).)))))...)))))...))))))))..((((........))))((((((..(.(((((((((((((..(((..((((..........)))..)..)))...((....))...((((()))))..(((((...(((..(((..)))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))).((((((......(((....)))..((.(((((((...(((.((((((((............(......((..((((((.(.).))))))))....)..))))))...(((((((((.(......))))))))))....))))))))))))..))..((((..(.((.....)).)..))))....(((......)))...(((((((...((([[[...(.(.(((((......(....<.....(((.((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((...........)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...(.....(((....)))...(.).......((((...)))).....)....))...(((((........)))))]]((((....(((((...(((((((....)))))))..((((....)))...(...((((((...((((((((((((((((((((((...{{{...)))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).)))..)).....((......)).)))).((((.....))))..)))....(((......(.((((..((..(....(.......(((((....(.{..).....)))))((.(((((((((((.((((((((.(((((((((....(((((())))))....)))))))))))))))))......)))))..)))))).))(...).......(((((((((.].(...........)...(((((((....((((.))))......))))))).}.....(((..((((((.(...(......((.(....).))......).)))))..)))))(.(.(.........).).).............((((..(((((()))))).))))...........)).))))))).)..)))..)))).)...)))))....)).[..((.((......].)).))....(((((..((((.......(((((.(((((...(((((.(((((((((.((((((((((((.((((.......[..(((((..(((.)))..........].))))).)))).)).))))))))))...(((((.....((((................(((((((((.........)))))))))..))))..)))))....)))))))))..)))))..((..(((((((...........))))))).))..((((((((.(.((((((.......))))))...).((....[[))....))))))))(..((....((.{{..))....)).)(((....)))...]]..}}(((((((..(((..]]]]]].))))))))))..)))..))))))).......>.....((((.(...((..))...).)))).................((((.((((((..(.(.(.(((......))).)...).)..((.(.....).))......)))))..)...)))).......((((((....))).)))...>..)..))).))))).....(.((.(.(..(((..(.(((((......(....).....))))).)(((.....((((....((.(((((((}}}.)))))..)).))...))))....))).((((...((((.....}.......))))...))))..)))...).).)).).((((((.((..((((.(..(((........(((((.(((()))).))))).......)))...(((..((((....((((.(((((((......)))))))))))...))))..)))...........)..))))..)))))))).(((((....(.......).......((.(((((((.((.....(.((.(..(((((......)))))..))).)....))....))).)))).))..))))).. Human nuclear pre-60S ribosomal subunit (State I3); 28S rRNA 8fl6 L1 154 2.62 RF00002 URS0000005270_9606 37410842 0003735 0005840 9606 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauuncaggacacauugaucaucgacacuucgaacgcacuugcggccccgggccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<.<<.....>>>.....(.<<<......>>.............>>>..)...>>>....<<....>><<<<<<<<<...>>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))(((((((((...))))))))).................... Human nuclear pre-60S ribosomal subunit (State J1); 5.8S rRNA 8fl6 L2 72 2.62 URS0002681439_9606 37410842 9606 ccgaucaaucgcccccggggugcgcggcugggggcucgcagggccccuccgucccccuaagcgcagacgaga .........<<<<<<..>>>.>>>.....<<<<<..<<.<<<<.>>>>.>>.>>>>>............... .........((((((()))).)))....((((((..((.((((.)))).)).)))))..)............ Human nuclear pre-60S ribosomal subunit (State J1); ITS2 rRNA 8fl6 L3 3405 2.62 RF02543 URS000075EC78_9606 37410842 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcgggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagngngaguucaagagggcgugaaaccguuaagaggaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggccggccgugucggcggcccggcggaucugggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucgggcccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggaggucgccgcgcucuccccccggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccggggggccacgcgcgcgucccccgaagagggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccnucuuacncggaccaaggagunuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccgcggccgaggugggaucccgaggccucuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccnanagauggugancuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauagnggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucuccgcaguuuuauccgguaaagcuuuaaauggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuugcngaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagcggcgcgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaunuuggugguagunnnaaauauucaaacgagaacuuugaaggccgaaguggngaaggguuccaugngaacagnanuugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccggcccugaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccnuauccgcagcaggucuncaaggugaacngccucuggnauguuggaacaanguagguaagggaagucggcaagcnggauccguaacuucnggauaaggauuggcucuaagggcugggucggucgggcuggggcgcgaagcggggucccguggaucgccccagccggccggcgccuagcagccgacuuagaacuggugcggaccaggngaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugccnagugcucugaaugucanagugangaaauucaaugaagcgcggnuaaacggcaagugancgagnuucccacugunccuaccuacuauccagcgaaaccacngncaagggcgggcuuggnggaaucagcggngaaagaagacccuguugagcuugacncuagucuggcacggugaaguuuuuucacugacccggugaggcggggggcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuguacaccugucaaacgguancgcaggnnuccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucagnacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggangugucagaaaaguuaccacagngaucuuguggcggccaagcgagcgacgucgcugaugucggnucuuccuaucauugugaagcagaauucaccaagcguungaunnuucacccacuaauagggaacgugngcugggnuuagancgucgugagacagguuaguuuuacccuacugaugnuguguuguugccaugguanuccugcucaguacgagaggaaccgcagnuncanacauuugguguaunugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauagcgccgcggagccucgguuggccucggauagccgguccccgggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu 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.........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((...(((((((((..))))).)))).....)))....((((((((((...((((((((.((((((((((..({((((......)))))....[[(...).(((....}]])))...).))))))).))))))))))..))))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............)...................((((((((..(((.((...((((((((.(((.....((((((((((((((((((.(((((.((...(((((.(((.)))))))))))))))))))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((.((.((((......((((((())))))).......)))))).)))........))))))..)))))))))))............((((((.(((((()))))).((((((.((((.(((((((((((.(((((((((((................))))))))))).).))))))).)))...)))))))).))..((((((((.........)))))).))..[.)))))).....))).)))))...)))))...)))))))).<((((.....))))((((((..(.(((((((((((((..(((..((((..........)))..)..)))...((....))...((((()))))..(((((...(((..((...[[[[.[[[[.))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))..).))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((.(((((((..[(((.((((((((.....(())......))))))...(((((((((.(......))))))))))]...))))))))))))..))..((((..(.(()).)..))))....((({..{..)))...(((((((...((([[[...(.(.(((((......(...}}...(((.((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((..........]]]].]]]]]................)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...(.....(((....)))...(.).......((((...........))))....)....))...(((((........)))))]]((((....(((((...(((((((....)))))))..((((....)))...(...((((((...((((((((((((((((((((((...{{{...)))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).)))..)).....((......)).)))).((((.....))))..)))....(((......(.((((..((..(....(.......(((((....(.[..).....)))))((.(((((((((((.((((((((.(((((((((....(((((())))))....)))))))))))))))))......)))))..)))))).))(...).......(((((((((.>.(...........)...(((((((....((((.....))))......))))))).].....(((..((((((.(...(......((.(....).))......).)))))..))))).......)).))))))).)..)))..)))).)...)))))....)).[.(((.((...>].)).)))...(((((..((((.......(((((.(((((...(((((.(((((((((.((((((...))))))...(((((.....((((................(((((((((.........)))))))))..))))..)))))....)))))))))..)))))..(((.)).)((((((...........))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(..((....((....{..))....)).)(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}.....)))..))))))).......((((.(...((..))...).))))[[...((((.((((((..(.(.(.(((......))).)...).)..((.....]]..))......)))))..)...)))).......((((((....))).)))...a..)..))).))))).....(.((.(.(..(((..(.(((((......(....).....))))).)(((.....((((....((.(((((((}}}.)))))..)).))...))))....))).((((...((((.....}.......))))...))))..)))...).).)).).((((((.((..((((.(..(((........(((((.(((()))).))))).......)))...(((..((((....((((.(((((((......)))))))))))...))))..)))...........)..))))..)))))))).(((((....(.......).......((.(((((((.((.....(.((.(..(((((......)))))..))).)....))....))).)))).))..))))).. Human nuclear pre-60S ribosomal subunit (State J1); 28S rRNA 8fl6 L4 120 2.62 RF00001 URS00000F9D45_9606 37410842 0003735 0005840 9606 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. Human nuclear pre-60S ribosomal subunit (State J1); 5S rRNA 8fl7 L1 154 2.55 RF00002 URS0000005270_9606 37410842 0003735 0005840 9606 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauuncaggacacauugaucaucgacacuucgaacgcacuugcggccccgggccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<.<<.....>>>.....(.<<<......>>.............>>>..)...>>>....<<....>><<<<<<<<<...>>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))(((((((((...))))))))).................... Human nuclear pre-60S ribosomal subunit (State J2); 5.8S rRNA 8fl7 L3 3409 2.55 RF02543 URS000075EC78_9606 37410842 0003735 0005840 9606 gcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcgggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagngngaguucaagagggcgugaaaccguuaagaggaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggccggccgugucggcggcccggcggaucugggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucgggcccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggaggucgccgcgcucuccccccggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccggggggccacgcgcgcgucccccgaagagggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccnucuuacncggaccaaggagunuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccgcggccgaggugggaucccgaggccucuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccnanagauggugancuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauagnggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucuccgcaguuuuauccgguaaagcuuuaaauggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuugcngaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagcggcgcgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaunuuggugguagunnnaaauauucaaacgagaacuuugaaggccgaaguggngaaggguuccaugngaacagnanuugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccggcccugaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccnuauccgcagcaggucuncaaggugaacngccucuggnauguuggaacaanguagguaagggaagucggcaagcnggauccguaacuucnggauaaggauuggcucuaagggcugggucggucgggcuggggcgcgaagcggggucccguggaucgccccagccggccggcgccuagcagccgacuuagaacuggugcggaccaggngaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugccnagugcucugaaugucanagugangaaauucaaugaagcgcggnuaaacggcaagugancgagnuucccacugunccuaccuacuauccagcgaaaccacngncaagggcgggcuuggnggaaucagcggngaaagaagacccuguugagcuugacncuagucuggcacggugaaguuuuuucacugacccggugaggcggggggcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuguacaccugucaaacgguancgcaggnnuccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucagnacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggangugucagaaaaguuaccacagngaucuuguggcggccaagcgagcgacgucgcuuuuuggaugucggnucuuccuaucauugugaagcagaauucaccaagcguungaunnuucacccacuaauagggaacgugngcugggnuuagancgucgugagacagguuaguuuuacccuacugaugnuguguuguugccaugguanuccugcucaguacgagaggaaccgcagnuncanacauuugguguaunugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauagcgccgcggagccucgguuggccucggauagccgguccccgggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu 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........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((...(((((((((..))))).)))).....)))....((((((((((...((((((((.((((((((((..({((((......)))))....[[(...).(((....}]])))...).))))))).))))))))))..))))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............)...................((((((((..(((.((...((((((((.(((.....((((((((((((((((((.(((((.((...(((((.(((.)))))))))))))))))))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((.((.((((......((((((())))))).......)))))).)))........))))))..)))))))))))............((((((.(((((()))))).((((((.((((.(((((((((((.(((((((((((................))))))))))).).))))))).)))...)))))))).))..(((((((((.......))))))).))..[.)))))).....))).)))))...)))))...)))))))).<((((.....))))((((((..(.(((((((((((((..(((..((((..........)))..)..)))...((....))...((((()))))..(((((...(((..((...[[[[.[[[[.))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))..).))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((.(((((((..[(((.((((((((.....(())......))))))...(((((((((.(......))))))))))]...))))))))))))..))..((((..(.(()).)..))))....((({..{..)))...(((((((...((([[[...(.(.(((((......(...}}...(((.((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((..........]]]].]]]]]................)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...(.....(((....)))...(.).......((((...........))))....)....))...(((((........)))))]]((((....(((((...(((((((....)))))))..((((....)))...(...((((((...((((((((((((((((((((((...{{{...)))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).)))..)).....((......)).)))).((((.....))))..)))....(((......(.((((..((..(....(.......(((((....(.[..).....)))))((.(((((((((((.(((((.((.(((((((((....(((((())))))....))))))))))).)))))......)))))..)))))).))(...).......(((((((((.>.(...........)...(((((((....((((.....))))......))))))).].....(((..((((((.(...(......((.(....).))......).)))))..))))).......)).))))))).)..)))..)))).)...)))))....)).[.(((.((...>].)).)))...(((((..((((.......(((((.(((((...(((((.(((((((((.((((((...))))))...(((((.....((((................(((((((((.........)))))))))..))))..)))))....)))))))))..)))))..(((.)).)((((((...........))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(..((....((....{..))....)).)(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}.....)))..))))))).......((((.(...((..))...).)))).....[[...((((.((((((..(.(.(.(((......))).)...).)..((.....]]..))......)))))..)...)))).......((((((....))).)))...a..)..))).))))).....(.((.(.(..(((..(.(((((......(....).....))))).)(((.....((((....((.(((((((}}}.)))))..)).))...))))....))).((((...((((.....}.......))))...))))..)))...).).)).).((((((.((..((((.(..(((........(((((.(((()))).))))).......)))...(((..((((....((((.(((((((......)))))))))))...))))..)))...........)..))))..)))))))).(((((....(.......).......((.(((((((.((.....(.((.(..(((((......)))))..))).)....))....))).)))).))..))))).. Human nuclear pre-60S ribosomal subunit (State J2); 28S rRNA 8fl7 L4 120 2.55 RF00001 URS00000F9D45_9606 37410842 0003735 0005840 9606 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. Human nuclear pre-60S ribosomal subunit (State J2); 5S rRNA 8fl9 L1 154 2.75 RF00002 URS0000005270_9606 37410842 0003735 0005840 9606 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauuncaggacacauugaucaucgacacuucgaacgcacuugcggccccgggccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<<<<....>>>>.....<.<<<......>>.............>>>..>...>>>....<<....>><<<<<<<<<...>>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))(((((((((...))))))))).................... Human nuclear pre-60S ribosomal subunit (State J3); 5.8S rRNA 8fl9 L3 3361 2.75 RF02543 URS000075EC78_9606 37410842 0003735 0005840 9606 gcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcgggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagngngaguucaagagggcgugaaaccguuaagaggaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggccggccgugucggcggcccggcggaucugggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucgggcccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggaggucgccgcgcucuccccccggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccggggggccacgcgcgcgucccccgaagagggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccnucuuacncggaccaaggagunuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccgcggccgaggugggaucccgaggccucuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccnanagauggugancuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauagnggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucuccgcaguuuuauccgguaaagcuuuaaauggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuugcngaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagcggcgcgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaunuuggugguagunnnaaauauucaaacgagaacuuugaaggccgaaguggngaaggguuccaugngaacagnanuugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgagcccugaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccnuauccgcagcaggucuncaaggugaacngccucuggnauguuggaacaanguagguaagggaagucggcaagcnggauccguaacuucnggauaaggauuggcucuaagggcugggucggucgcggccggcgccuagcagccgacuuagaacuggugcggaccaggngaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugccnagugcucugaaugucanagugangaaauucaaugaagcgcggnuaaacggcaagugancgagnuucccacugunccuaccuacuauccagcgaaaccacngncaagggcgggcuuggnggaaucagcggngaaagaagacccuguugagcuugacncuagucuggcacggugaaguuuuuucacugacccggugaggcggggggcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuguacaccugucaaacgguancgcaggnnuccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucagnacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggangugucagaaaaguuaccacagngaucuuguggcggccaagcgagcgacgucgcuuuuuggaugucggnucuuccuaucauugugaagcagaauucaccaagcguungaunnuucacccacuaauagggaacgugngcugggnuuagancgucgugagacagguuaguuuuacccuacugaugnuguguuguugccaugguanuccugcucaguacgagaggaaccgcagnuncanacauuugguguaunugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauagcgccgcggagccucgguuggccucggauagccgguccccgggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu ........................<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<<...<<<<<<<<<..>>>>>.>>>>.....>>>>>..<<<<<<<<<<...<<<<<<<<.<<<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>.>>>>>>>>>>..>>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<......>>>................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<<<<<<<<<<.<<<<<.<<...<<<<<.<<...>>>>>>>>>>>>>>>>>>...>>>>>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<<<<<<<<<<<<<<<<<...<<..<<<.<<.<<<<......<<<<<<..>>>>>>.......>>>>>>.>>>........>>>>>>..>>>>>>>>>>>............<<<<<<.<<<<<..>>>>>.<<<<<<.<<<<.<<<<<<<<<<..<<<<<<<<<<<<<...........>.>>>>>>>>>>>>...>>>>>>>.>>>...>>>>>>>>.>>..<<<<<<<<<.......>>>>>>>.>>....>>>>>>.....>>>.>>>>>...>>>>>...>>>>>>>>..<<<<.....>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<..>>>>..<<<<<...<<<..<<<..((((.((((>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<...<<<.<<<<<<<<<...<<<.>>>...>>>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<..>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<..........)))).)))).................>>>>>>>>>....>>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<....<<.....>>..>>>>>....((<<<<<<...<<....<<<....>>>.............<<<<..>>>>...>>....>>>..<<<<<........>>>>>))<<<<....<<<<<..<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<...............<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<.<<<<<<<..>>>>>>>......>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>..<....<<<..<<<<<<.<..<<<.....<<<<....>>>>.....>>>>>>>>..>>>>>....>..>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>...<<<<<<......>>>>>>...<<<<<..<<<........<<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<.....>>>>>...<<<<<.....<<<<................<<<<<<<<<<.......>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<.>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))].....<<<<<<<..<<<..)))))).>>>>>>>>>>.........>>>>..>>>>>>>.......<<<<<<...<<..>>...>>>>>>.....((...<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.....))..>>>.....>>>>>..>...>>>>......<<<<<<<....>>>.>>>>........>>>.>>>>>.....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<]]].>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.<<<<<<.<<..<<<<....<<<........<<<<<.<<<<>>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>..............>>>>..>>>>>>>>.<<<<<....................<<.<<<<<<<.<<.....<<<<....<<<<<......>>>>>...>>>>....>>....>>>.>>>>.>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((...(((((((((..))))).)))).....)))....((((((((((...((((((((.((((((((((..({((((......)))))....[[(...).(((....}]])))...).))))))).))))))))))..))))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............)...................((((((((..(((.((...((((((((.(((.....((((((((((((((((((.(((((.((...(((((.(((.)))))))))))))))))))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((.((.((((......((((((())))))).......)))))).)))........))))))..)))))))))))............((((((.(((((()))))).((((((.((((.(((((((((((.(((((((((((................))))))))))).).))))))).)))...)))))))).))..((((((((.........)))))).))..[.)))))).....))).)))))...)))))...)))))))).<((((.....))))((((((..(.(((((((((((((..(((..((((..........)))..)..)))...((....))...((((()))))..(((((...(((..((...[[[[.[[[[.))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))..).))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((.(((((((..[(((.((((((((...............))))))...(((((((((.(......))))))))))]...))))))))))))..))..((((..(.(()).)..))))....((({..{..)))...(((((((...((([[[...(.(.(((((......(...}}...(((.((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((..........]]]].]]]]]................)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...(.....(((....)))...(.).......((((..))))....)....))...(((((........)))))]]((((....(((((...(((((((....)))))))..((((....)))...(...((((((...((((((((((((((((((((((...{{{...)))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).)))..)).....((......)).)))).((((.....))))..)))....(((......(.((((..((..(....(.......(((((....(.[..).....)))))((.(((((((((((.(((((.(()).)))))......)))))..)))))).))(...).......(((((((((.>.(...........)...(((((((....((((.....))))......))))))).].....(((..((((((.(...(......((.(....).))......).)))))..))))).......)).))))))).)..)))..)))).)...)))))....)).[.(((.((...>].)).)))...(((((..((((.......(((((.(((((...(((((.(((((((((.((((((...))))))...(((((.....((((................(((((((((.........)))))))))..))))..)))))....)))))))))..)))))..(((.)).)((((((...........))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(..((....((....{..))....)).)(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}.....)))..))))))).......((((.(...((..))...).)))).....[[...((((.((((((..(.(.(.(((......))).)...).)..((.....]]..))......)))))..)...)))).......((((((....))).)))...a..)..))).))))).....(.((.(.(..(((..(.(((((......(....).....))))).)(((.....((((....((.(((((((}}}.)))))..)).))...))))....))).((((...((((.....}.......))))...))))..)))...).).)).).((((((.((..((((.(..(((........(((((.(((()))).))))).......)))...(((..((((....((((.(((((((......)))))))))))...))))..)))...........)..))))..)))))))).(((((....(.......).......((.(((((((.((.....(.((.(..(((((......)))))..))).)....))....))).)))).))..))))).. Human nuclear pre-60S ribosomal subunit (State J3); 28S rRNA 8fl9 L4 120 2.75 RF00001 URS00000F9D45_9606 37410842 0003735 0005840 9606 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. Human nuclear pre-60S ribosomal subunit (State J3); 5S rRNA 8fla L1 154 2.63 RF00002 URS0000005270_9606 37410842 0003735 0005840 9606 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauuncaggacacauugaucaucgacacuucgaacgcacuugcggccccgggccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<.<<.....>>>.....(.<<<......>>.............>>>..)...>>>....<<....>><<<<<<<<<...>>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))(((((((((...))))))))).................... Human nuclear pre-60S ribosomal subunit (State K1); 5.8S rRNA 8fla L2 72 2.63 URS0002681439_9606 37410842 9606 ccgaucaaucgcccccggggugcgcggcugggggcucgcagggccccuccgucccccuaagcgcagacgaga .........<<<<<<..>>>.>>>.....<<<<<..<<.<<<<.>>>>.>>.>>>>>............... .........((((((()))).)))....((((((..((.((((.)))).)).)))))..)............ Human nuclear pre-60S ribosomal subunit (State K1); ITS2 rRNA 8fla L3 3420 2.63 RF02543 URS000075EC78_9606 37410842 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcgggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagngngaguucaagagggcgugaaaccguuaagaggaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggccggccgugucggcggcccggcggaucugggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucgggcccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggaggucgccgcgcucuccccccggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccggggggccacgcgcgcgucccccgaagagggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccnucuugnaacncggaccaaggagunuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccgcggccgaggugggaucccgaggccucuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccnanagauggugancuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauagnggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucuccgcaguuuuauccgguaaaguuuaaauggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcngaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccgaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagcggcgcgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaunuuggugguagunnnaaauauucaaacgagaacuuugaaggccgaaguggngaaggguuccaugngaacagnanuugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccggcccugaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccnuauccgcagcaggucuncaaggugaacngccucuggnauguuggaacaanguagguaagggaagucggcaagcnggauccguaacuucnggauaaggauuggcucuaagggcugggucggucgggcuggggcgcgaagcggggucccguggaucgccccagccggccggcgccuagcagccgacuuagaacuggugcggaccaggngaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugccnagugcucugaaugucanagugangaaauucaaugaagcgcggnuaaacggcaagugancgagnuucccacugunccuaccuacuauccagcgaaaccacngncaagggaacgggcuuggnggaaucagcggngaaagaagacccuguugagcuugacncuagucuggcacggugaaguuuuuucacugacccggugaggcggggggcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuguacaccugucaaacgguancgcaggnnuccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucagnacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggangugucagaaaaguuaccacagngaucuuguggcggccaagcgagcgacgucgcuuuuuggaugucggnucuuccuaucauugugaagcagaauucaccaagcguungaunnuucacccacuaauagggaacgugngcugggnuuagancgucgugagacagguuaguuuuacccuacugaugnuguguuguugccaugguanuccugcucaguacgagaggaaccgcagnuncanacauuugguguaunugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauagcgccgcggagccucgguuggccucggauagccgguccccgggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu 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.........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((...(((((((((..))))).)))).....)))....((((((((((...((((((((.((((((((((..({((((......)))))....[[(...).(((....}]])))...).))))))).))))))))))..))))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............)...................((((((((..(((.((...((((((((.(((.....((((((((((((((((((.(((((.((...(((((.(((.)))))))))))))))))))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((.((.((((......((((((())))))).......)))))).)))........))))))..)))))))))))............((((((.(((((()))))).((((((.((((.(((((((((((.(((((((((((................))))))))))).).))))))).)))...)))))))).))..(((((((((.......))))))).))..[.)))))).....))).)))))...)))))...)))))))).<((((........))))((((((..(.(((((((((((((..(((..((((..........)))..)..)))...((....))...((((()))))..(((((...(((..((...[[[[.[[[[.))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))..).))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((.(((((((..[(((.((((((((.....(..).....))))))...(((((((((.(......))))))))))]...))))))))))))..))..((((..(.((.....)).)..))))....(((......)))...(((((((...((([[[...(.(.(((((......(.........(((.((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((..........]]]].]]]]]................)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...(.....(((....)))...(.).......((((...........))))....)....))...(((((........)))))]]((((....(((((...(((((((....)))))))..((((....)))...(...((((((...((((((((((((((((((((((...{{{...)))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).)))..)).....((......)).)))).((((.....))))..)))....(((......(.((((..((..(....(.......(((((....(.[..).....)))))((.(((((((((((.((((((((.(((((((((....(((((())))))....)))))))))))))))))......)))))..)))))).))(...).......(((((((((.>.(...........)...(((((((....((((.....))))......))))))).].....(((..((((((.(...(......((.(....).))......).)))))..))))).......)).))))))).)..)))..)))).)...)))))....)).[.(((.((.....>].)).)))...(((((..((((.......(((((.(((((...(((((.(((((((((.((((((...))))))...(((((.....((((................(((((((((.........)))))))))..))))..)))))....)))))))))..)))))..(((.)).)((((((...........))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(..((....((....{..))....)).)(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}.....)))..))))))).......((((.(...((..))...).)))).....[[...((((.((((((..(.(.(.((........)).)...).)..((.....]]..))......)))))..)...)))).......((((((....))).)))...a..)..))).))))).....(.((.(.(..(((..(.(((((......(....).....))))).)(((.....((((....((.(((((((}}}.)))))..)).))...))))....))).((((...((((.....}.......))))...))))..)))...).).)).).((((((.((..((((.(..(((........(((((.(((()))).))))).......)))...(((..((((....((((.(((((((......)))))))))))...))))..)))...........)..))))..)))))))).(((((....(.......).......((.(((((((.((.....(.((.(..(((((......)))))..))).)....))....))).)))).))..))))).. Human nuclear pre-60S ribosomal subunit (State K1); 28S rRNA 8fla L4 120 2.63 RF00001 URS00000F9D45_9606 37410842 0003735 0005840 9606 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. Human nuclear pre-60S ribosomal subunit (State K1); 5S rRNA 8flb L1 154 2.55 RF00002 URS0000005270_9606 37410842 0003735 0005840 9606 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauuncaggacacauugaucaucgacacuucgaacgcacuugcggccccgggccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<.<<.....>>>.....(.<<<......>>.............>>>..)...>>>....<<....>><<<<<<<<<...>>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))(((((((((...))))))))).................... Human nuclear pre-60S ribosomal subunit (State K2); 5.8S rRNA 8flb L3 3420 2.55 RF02543 URS000075EC78_9606 37410842 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcgggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagngngaguucaagagggcgugaaaccguuaagaggaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggccggccgugucggcggcccggcggaucugggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucgggcccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggaggucgccgcgcucuccccccggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccggggggccacgcgcgcgucccccgaagagggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccnucuugnaacncggaccaaggagunuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccgcggccgaggugggaucccgaggccucuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccnanagauggugancuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauagnggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucuccgcaguuuuauccgguaaaguuuaaauggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcngaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccgaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagcggcgcgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaunuuggugguagunnnaaauauucaaacgagaacuuugaaggccgaaguggngaaggguuccaugngaacagnanuugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccggcccugaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccnuauccgcagcaggucuncaaggugaacngccucuggnauguuggaacaanguagguaagggaagucggcaagcnggauccguaacuucnggauaaggauuggcucuaagggcugggucggucgggcuggggcgcgaagcggggucccguggaucgccccagccggccggcgccuagcagccgacuuagaacuggugcggaccaggngaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugccnagugcucugaaugucanagugangaaauucaaugaagcgcggnuaaacggcaagugancgagnuucccacugunccuaccuacuauccagcgaaaccacngncaagggaacgggcuuggnggaaucagcggngaaagaagacccuguugagcuugacncuagucuggcacggugaaguuuuuucacugacccggugaggcggggggcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuguacaccugucaaacgguancgcaggnnuccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucagnacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggangugucagaaaaguuaccacagngaucuuguggcggccaagcgagcgacgucgcuuuuuggaugucggnucuuccuaucauugugaagcagaauucaccaagcguungaunnuucacccacuaauagggaacgugngcugggnuuagancgucgugagacagguuaguuuuacccuacugaugnuguguuguugccaugguanuccugcucaguacgagaggaaccgcagnuncanacauuugguguaunugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauagcgccgcggagccucgguuggccucggauagccgguccccgggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu 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.........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((...(((((((((..))))).)))).....)))....((((((((((...((((((((.((((((((((..({((((......)))))....[[(...).(((....}]])))...).))))))).))))))))))..))))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............)...................((((((((..(((.((...((((((((.(((.....((((((((((((((((((.(((((.((...(((((.(((.)))))))))))))))))))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((.((.((((......((((((())))))).......)))))).)))........))))))..)))))))))))............((((((.(((((()))))).((((((.((((.(((((((((((.(((((((((((................))))))))))).).))))))).)))...)))))))).))..(((((((((.......))))))).))..[.)))))).....))).)))))...)))))...)))))))).<((((........))))((((((..(.(((((((((((((..(((..((((..........)))..)..)))...((....))...((((()))))..(((((...(((..((...[[[[.[[[[.))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))..).))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((.(((((((..[(((.((((((((.....(..).....))))))...(((((((((.(......))))))))))]...))))))))))))..))..((((..(.((.....)).)..))))....(((...{..)))...(((((((...((([[[...(.(.(((((......(...}.....(((.((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((..........]]]].]]]]]................)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...(.....(((....)))...(.).......((((...........))))....)....))...(((((........)))))]]((((....(((((...(((((((....)))))))..((((....)))...(...((((((...((((((((((((((((((((((...{{{...)))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).)))..)).....((......)).)))).((((.....))))..)))....(((......(.((((..((..(....(.......(((((....(.[..).....)))))((.(((((((((((.((((((((.(((((((((....(((((())))))....)))))))))))))))))......)))))..)))))).))(...).......(((((((((.>.(...........)...(((((((....((((.....))))......))))))).].....(((..((((((.(...(......((.(....).))......).)))))..))))).......)).))))))).)..)))..)))).)...)))))....)).[.(((.((.....>].)).)))...(((((..((((.......(((((.(((((...(((((.(((((((((.((((((...))))))...(((((.....((((................(((((((((.........)))))))))..))))..)))))....)))))))))..)))))..(((.)).)((((((...........))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(..((....((....{..))....)).)(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}.....)))..))))))).......((((.(...((..))...).)))).....[[...((((.((((((..(.(.(.((........)).)...).)..((.....]]..))......)))))..)...)))).......((((((....))).)))...a..)..))).))))).....(.((.(.(..(((..(.(((((......(....).....))))).)(((.....((((....((.(((((((}}}.)))))..)).))...))))....))).((((...((((.....}.......))))...))))..)))...).).)).).((((((.((..((((.(..(((........(((((.(((()))).))))).......)))...(((..((((....((((.(((((((......)))))))))))...))))..)))...........)..))))..)))))))).(((((....(.......).......((.(((((((.((.....(.((.(..(((((......)))))..))).)....))....))).)))).))..))))).. Human nuclear pre-60S ribosomal subunit (State K2); 28S rRNA 8flb L4 120 2.55 RF00001 URS00000F9D45_9606 37410842 0003735 0005840 9606 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. Human nuclear pre-60S ribosomal subunit (State K2); 5S rRNA 8flc L1 154 2.76 RF00002 URS0000005270_9606 37410842 0003735 0005840 9606 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauuncaggacacauugaucaucgacacuucgaacgcacuugcggccccgggccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<.<<.....>>>.....(.<<<......>>.............>>>..)...>>>....<<....>><<<<<<<<<...>>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))(((((((((...))))))))).................... Human nuclear pre-60S ribosomal subunit (State K3); 5.8S rRNA 8flc L3 3373 2.76 RF02543 URS000075EC78_9606 37410842 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcgggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagngngaguucaagagggcgugaaaccguuaagaggaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggccggccgugucggcggcccggcggaucugggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucgggcccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggaggucgccgcgcucuccccccggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccggggggccacgcgcgcgucccccgaagagggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccnucuugnaacncggaccaaggagunuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccgcggccgaggugggaucccgaggccucuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccnanagauggugancuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauagnggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucuccgcaguuuuauccgguaaaguuuaaauggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcngaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccgaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagcggcgcgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaunuuggugguagunnnaaauauucaaacgagaacuuugaaggccgaaguggngaaggguuccaugngaacagnanuugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgagcccucgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccnuauccgcagcaggucuncaaggugaacngccucuggnauguuggaacaanguagguaagggaagucggcaagcnggauccguaacuucnggauaaggauuggcucuaagggcugggucggucgcggccggcgccuagcagccgacuuagaacuggugcggaccaggngaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugccnagugcucugaaugucanagugangaaauucaaugaagcgcggnuaaacggcaagugancgagnuucccacugunccuaccuacuauccagcgaaaccacngncaagggaacgggcuuggnggaaucagcggngaaagaagacccuguugagcuugacncuagucuggcacggugaaguuuuuucacugacccggugaggcggggggcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuguacaccugucaaacgguancgcaggnnuccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucagnacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggangugucagaaaaguuaccacagngaucuuguggcggccaagcgagcgacgucgcuuuuuggaugucggnucuuccuaucauugugaagcagaauucaccaagcguungaunnuucacccacuaauagggaacgugngcugggnuuagancgucgugagacagguuaguuuuacccuacugaugnuguguuguugccaugguanuccugcucaguacgagaggaaccgcagnuncanacauuugguguaunugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauagcgccgcggagccucgguuggccucggauagccgguccccgggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu 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.........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((...(((((((((..))))).)))).....)))....((((((((((...((((((((.((((((((((..({((((......)))))....[[(...).(((....}]])))...).))))))).))))))))))..))))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............)...................((((((((..(((.((...((((((((.(((.....((((((((((((((((((.(((((.((...(((((.(((.)))))))))))))))))))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((.((.((((......((((((())))))).......)))))).)))........))))))..)))))))))))............((((((.(((((()))))).((((((.((((.(((((((((((.(((((((((((................))))))))))).).))))))).)))...)))))))).))..(((((((((.......))))))).))..[.)))))).....))).)))))...)))))...)))))))).<((((........))))((((((..(.(((((((((((((..(((..((((..........)))..)..)))...((....))...((((()))))..(((((...(((..((...[[[[.[[[[.))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))..).))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((.(((((((..[(((.((((((((.....(..).....))))))...(((((((((.(......))))))))))]...))))))))))))..))..((((..(.((.....)).)..))))....(((......)))...(((((((...((([[[...(.(.(((((......(.........(((.((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((..........]]]].]]]]]................)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...(.....(((....)))...(.).......((((..)))).....)....))...(((((........)))))]]((((....(((((...(((((((....)))))))..((((....)))...(...((((((...((((((((((((((((((((((...{{{...)))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).)))..)).....((......)).)))).((((.....))))..)))....(((......(.((((..((..(....(.......(((((....(.[..).....)))))((.(((((((((((.(((((((())))))))......)))))..)))))).))(...).......(((((((((.>.(...........)...(((((((....((((.....))))......))))))).].....(((..((((((.(...(......((.(....).))......).)))))..))))).......)).))))))).)..)))..)))).)...)))))....)).[.(((.((.....>].)).)))...(((((..((((.......(((((.(((((...(((((.(((((((((.((((((...))))))...(((((.....((((................(((((((((.........)))))))))..))))..)))))....)))))))))..)))))..(((.)).)((((((...........))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(..((....((....{..))....)).)(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}.....)))..))))))).......((((.(...((..))...).)))).....[[...((((.((((((..(.(.(.((........)).)...).)..((.....]]..))......)))))..)...)))).......((((((....))).)))...a..)..))).))))).....(.((.(.(..(((..(.(((((......(....).....))))).)(((.....((((....((.(((((((}}}.)))))..)).))...))))....))).((((...((((.....}.......))))...))))..)))...).).)).).((((((.((..((((.(..(((........(((((.(((()))).))))).......)))...(((..((((....((((.(((((((......)))))))))))...))))..)))...........)..))))..)))))))).(((((....(.......).......((.(((((((.((.....(.((.(..(((((......)))))..))).)....))....))).)))).))..))))).. Human nuclear pre-60S ribosomal subunit (State K3); 28S rRNA 8flc L4 120 2.76 RF00001 URS00000F9D45_9606 37410842 0003735 0005840 9606 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. Human nuclear pre-60S ribosomal subunit (State K3); 5S rRNA 8fld L1 154 2.58 RF00002 URS0000005270_9606 37410842 0003735 0005840 9606 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauuncaggacacauugaucaucgacacuucgaacgcacuugcggccccgggccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<.<<.....>>>.....(.<<<......>>.............>>>..)...>>>....<<....>><<<<<<<<<...>>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))(((((((((...))))))))).................... Human nuclear pre-60S ribosomal subunit (State L1); 5.8S rRNA 8fld L2 72 2.58 URS0002681439_9606 37410842 9606 ccgaucaaucgcccccggggugcgcggcugggggcucgcagggccccuccgucccccuaagcgcagacgaga .........<<<<<<..>>>.>>>.....<<<<<..<<.<<<<.>>>>.>>.>>>>>............... .........((((((()))).)))....((((((..((.((((.)))).)).)))))..)............ Human nuclear pre-60S ribosomal subunit (State L1); ITS2 rRNA 8fld L3 3372 2.58 RF02543 URS000075EC78_9606 37410842 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcgggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagngngaguucaagagggcgugaaaccguuaagaggaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggccggccgugucggcggcccggcggaucugggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucgggcccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggaggucgccgcgcucuccccccggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccggggggccacgcgcgcgucccccgaagagggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccnucuugnaacncggaccaaggagunuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccgcggccgaggugggaucccgaggccucuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccnanagauggugancuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauagnggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucuccgcaguuuuauccgguaaagcgaaugauuagagguaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuugcngaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccaaaagguguugguugauauagacagcaggacgguccgcuaagaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagcggcgcgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaunuuggugguagunnnaaauauucaaacgagaacuuugaaggccgaaguggngaaggguuccaugngaacagnanuugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccggcccugaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccnuauccgcagcaggucuncaaggugaacngccucuggnauguuggaacaanguagguaagggaagucggcaagcnggauccguaacuucnggauaaggauuggcucuaagggcugggucggucgggcuggggcgcgaagcggggucccguggaucgccccagccggccggcgccuagcagccgacuuagaacuggugcggaccaggngaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugccnagugcucugaaugucanagugangaaauucaaugaagcgcggnuaaacggcaagugancgagnuucccacugunccuaccuacuauccagcgaaaccacngncaaggcgggcuuggnggaaucagcggngaaagaagacccuguugagcuugacncuagucuggcacggugaaguuuuuucacugacccggugaggcggggggcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuguacaccugucaaacgguancgcaggnnuccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucagnacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggangugucagaaaaguuaccacagngaugaugucggnucuuccuaucauugugaagcagaauucaccaagcguungaunnuucacccacuaauagggaacgugngcugggnuuagancgucgugagacagguuaguuuuacccuacugaugnuguguuguugccaugguanuccugcucaguacgagaggaaccgcagnuncanacauuugguguaunugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauagcgccgcggagccucgguuggccucggauagccgguccccgggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu 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.........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((...(((((((((..))))).)))).....)))....((((((((((...((((((((.((((((((((..({((((......)))))....[[(...).(((....}]])))...).))))))).))))))))))..))))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............)...................((((((((..(((.((...((((((((.(((.....((((((((((((((((((.(((((.((...(((((.(((.)))))))))))))))))))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((.((.((((......((((((())))))).......)))))).)))........))))))..)))))))))))............((((((.(((((()))))).((((((.((((.(((((((((((.(((((((((((................))))))))))).).))))))).)))...)))))))).))..(((((((((.......))))))).))..[.)))))).....))).)))))...)))))...)))))))).<((((........))))((((((..(.(((((((((((((..(((..((((..........)))..)..)))...((....))...((((()))))..(((((...(((..((...[[[[.[[[[.))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))..).))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((.(((((((..[(((.((((((((.....((.....((.....((..)).....))...))......))))))...(((((((((.(......))))))))))]...))))))))))))..))..((((..(.(()).)..))))....((({..{..)))...(((((((...((([[[...(.(.(((((......(...}}...(((.((((((((((.....{.(((((.(((.)))......)))))...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((..........]]]].]]]]]................)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...(.....(((....)))...(.).......((((...........))))....)....))...(((((........)))))]]((((....(((((...(((((((....)))))))..((((....)))...(...((((((...((((((((((((((((((((((...{{{...)))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).)))..)).....((......)).)))).((((.....))))..)))....(((......(.((((..((..(....(.......(((((....(.[..).....)))))((.(((((((((((.((((((((.(((((((((....(((((())))))....)))))))))))))))))......)))))..)))))).))(...).......(((((((((.>.(...........)...(((((((....((((.....))))......))))))).].....(((..((((((.(...(......((.(....).))......).)))))..))))).......)).))))))).)..)))..)))).)...)))))....)).[.(((.((..>].)).)))...(((((..((((.......(((((.(((((...(((((.(((((((((.((((((...))))))...(((((.....((((................(((((((((.........)))))))))..))))..)))))....)))))))))..)))))..(((.)).)((((((...........))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(..((....((....{..))....)).)(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}.....)))..)))))))..[[...((((.((((((..(.(.(.((........)).)...).)..((.....]]..))......)))))..)...)))).......((((((....))).)))...a..)..))).))))).....(.((.(.(..(((..(.(((((......(....).....))))).)(((.....((((....((.(((((((}}}.)))))..)).))...))))....))).((((...((((.....}.......))))...))))..)))...).).)).).((((((.((..((((.(..(((........(((((.(((()))).))))).......)))...(((..((((....((((.(((((((......)))))))))))...))))..)))...........)..))))..)))))))).(((((....(.......).......((.(((((((.((.....(.((.(..(((((......)))))..))).)....))....))).)))).))..))))).. Human nuclear pre-60S ribosomal subunit (State L1); 28S rRNA 8fld L4 120 2.58 RF00001 URS00000F9D45_9606 37410842 0003735 0005840 9606 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. Human nuclear pre-60S ribosomal subunit (State L1); 5S rRNA 8fle L1 154 2.48 RF00002 URS0000005270_9606 37410842 0003735 0005840 9606 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauuncaggacacauugaucaucgacacuucgaacgcacuugcggccccgggccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<.<<.....>>>.....(.<<<......>>.............>>>..)...>>>....<<....>><<<<<<<<<...>>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))(((((((((...))))))))).................... Human nuclear pre-60S ribosomal subunit (State L2); 5.8S rRNA 8fle L3 3372 2.48 RF02543 URS000075EC78_9606 37410842 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcgggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagngngaguucaagagggcgugaaaccguuaagaggaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggccggccgugucggcggcccggcggaucugggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucgggcccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggaggucgccgcgcucuccccccggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccggggggccacgcgcgcgucccccgaagagggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccnucuugnaacncggaccaaggagunuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccgcggccgaggugggaucccgaggccucuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccnanagauggugancuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauagnggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucuccgcaguuuuauccgguaaagcgaaugauuagagguaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuugcngaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccaaaagguguugguugauauagacagcaggacgguccgcuaagaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagcggcgcgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaunuuggugguagunnnaaauauucaaacgagaacuuugaaggccgaaguggngaaggguuccaugngaacagnanuugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccggcccugaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccnuauccgcagcaggucuncaaggugaacngccucuggnauguuggaacaanguagguaagggaagucggcaagcnggauccguaacuucnggauaaggauuggcucuaagggcugggucggucgggcuggggcgcgaagcggggucccguggaucgccccagccggccggcgccuagcagccgacuuagaacuggugcggaccaggngaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugccnagugcucugaaugucanagugangaaauucaaugaagcgcggnuaaacggcaagugancgagnuucccacugunccuaccuacuauccagcgaaaccacngncaaggcgggcuuggnggaaucagcggngaaagaagacccuguugagcuugacncuagucuggcacggugaaguuuuuucacugacccggugaggcggggggcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuguacaccugucaaacgguancgcaggnnuccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucagnacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggangugucagaaaaguuaccacagngaugaugucggnucuuccuaucauugugaagcagaauucaccaagcguungaunnuucacccacuaauagggaacgugngcugggnuuagancgucgugagacagguuaguuuuacccuacugaugnuguguuguugccaugguanuccugcucaguacgagaggaaccgcagnuncanacauuugguguaunugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauagcgccgcggagccucgguuggccucggauagccgguccccgggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu 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.........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((...(((((((((..))))).)))).....)))....((((((((((...((((((((.((((((((((..({((((......)))))....[[(...).(((....}]])))...).))))))).))))))))))..))))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............)...................((((((((..(((.((...((((((((.(((.....((((((((((((((((((.(((((.((...(((((.(((.)))))))))))))))))))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((.((.((((......((((((())))))).......)))))).)))........))))))..)))))))))))............((((((.(((((()))))).((((((.((((.(((((((((((.(((((((((((................))))))))))).).))))))).)))...)))))))).))..(((((((((.......))))))).))..[.)))))).....))).)))))...)))))...)))))))).<((((........))))((((((..(.(((((((((((((..(((..((((..........)))..)..)))...((....))...((((()))))..(((((...(((..((...[[[[.[[[[.))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))..).))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((.(((((((..[(((.((((((((.....((.....((.....((..)).....))...))......))))))...(((((((((.(......))))))))))]...))))))))))))..))..((((..(.(()).)..))))....((({..{..)))...(((((((...((([[[...(.(.(((((......(...}}...(((.((((((((((.....{.(((((.(((.)))......)))))...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((..........]]]].]]]]]................)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...(.....(((....)))...(.).......((((...........))))....)....))...(((((........)))))]]((((....(((((...(((((((....)))))))..((((....)))...(...((((((...((((((((((((((((((((((...{{{...)))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).)))..)).....((......)).)))).((((.....))))..)))....(((......(.((((..((..(....(.......(((((....(.[..).....)))))((.(((((((((((.((((((((.(((((((((....(((((())))))....)))))))))))))))))......)))))..)))))).))(...).......(((((((((.>.(...........)...(((((((....((((.....))))......))))))).].....(((..((((((.(...(......((.(....).))......).)))))..))))).......)).))))))).)..)))..)))).)...)))))....)).[.(((.((..>].)).)))...(((((..((((.......(((((.(((((...(((((.(((((((((.((((((...))))))...(((((.....((((................(((((((((.........)))))))))..))))..)))))....)))))))))..)))))..(((.)).)((((((...........))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(..((....((....{..))....)).)(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}.....)))..)))))))..[[...((((.((((((..(.(.(.((........)).)...).)..((.....]]..))......)))))..)...)))).......((((((....))).)))...a..)..))).))))).....(.((.(.(..(((..(.(((((......(....).....))))).)(((.....((((....((.(((((((}}}.)))))..)).))...))))....))).((((...((((.....}.......))))...))))..)))...).).)).).((((((.((..((((.(..(((........(((((.(((()))).))))).......)))...(((..((((....((((.(((((((......)))))))))))...))))..)))...........)..))))..)))))))).(((((....(.......).......((.(((((((.((.....(.((.(..(((((......)))))..))).)....))....))).)))).))..))))).. Human nuclear pre-60S ribosomal subunit (State L2); 28S rRNA 8fle L4 120 2.48 RF00001 URS00000F9D45_9606 37410842 0003735 0005840 9606 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. Human nuclear pre-60S ribosomal subunit (State L2); 5S rRNA 8flf L1 154 2.65 RF00002 URS0000005270_9606 37410842 0003735 0005840 9606 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauuncaggacacauugaucaucgacacuucgaacgcacuugcggccccgggccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<.<<.....>>>.....(.<<<......>>.............>>>..)...>>>....<<....>><<<<<<<<<...>>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))(((((((((...))))))))).................... Human nuclear pre-60S ribosomal subunit (State L3); 5.8S rRNA 8flf L3 3325 2.65 RF02543 URS000075EC78_9606 37410842 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcgggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagngngaguucaagagggcgugaaaccguuaagaggaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggccggccgugucggcggcccggcggaucugggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucgggcccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggaggucgccgcgcucuccccccggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccggggggccacgcgcgcgucccccgaagagggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccnucuugnaacncggaccaaggagunuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccgcggccgaggugggaucccgaggccucuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccnanagauggugancuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauagnggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucuccgcaguuuuauccgguaaagcgaaugauuagagguaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuugcngaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccaaaagguguugguugauauagacagcaggacgguccgcuaagaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagcggcgcgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaunuuggugguagunnnaaauauucaaacgagaacuuugaaggccgaaguggngaaggguuccaugngaacagnanuugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgagcccucgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccnuauccgcagcaggucuncaaggugaacngccucuggnauguuggaacaanguagguaagggaagucggcaagcnggauccguaacuucnggauaaggauuggcucuaagggcugggucggucgcggccggcgccuagcagccgacuuagaacuggugcggaccaggngaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugccnagugcucugaaugucanagugangaaauucaaugaagcgcggnuaaacggcaagugancgagnuucccacugunccuaccuacuauccagcgaaaccacngncaaggcgggcuuggnggaaucagcggngaaagaagacccuguugagcuugacncuagucuggcacggugaaguuuuuucacugacccggugaggcggggggcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuguacaccugucaaacgguancgcaggnnuccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucagnacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggangugucagaaaaguuaccacagngaugaugucggnucuuccuaucauugugaagcagaauucaccaagcguungaunnuucacccacuaauagggaacgugngcugggnuuagancgucgugagacagguuaguuuuacccuacugaugnuguguuguugccaugguanuccugcucaguacgagaggaaccgcagnuncanacauuugguguaunugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauagcgccgcggagccucgguuggccucggauagccgguccccgggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu 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.........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((...(((((((((..))))).)))).....)))....((((((((((...((((((((.((((((((((..({((((......)))))....[[(...).(((....}]])))...).))))))).))))))))))..))))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............)...................((((((((..(((.((...((((((((.(((.....((((((((((((((((((.(((((.((...(((((.(((.)))))))))))))))))))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((.((.((((......((((((())))))).......)))))).)))........))))))..)))))))))))............((((((.(((((()))))).((((((.((((.(((((((((((.(((((((((((................))))))))))).).))))))).)))...)))))))).))..(((((((((.......))))))).))..[.)))))).....))).)))))...)))))...)))))))).<((((........))))((((((..(.(((((((((((((..(((..((((..........)))..)..)))...((....))...((((()))))..(((((...(((..((...[[[[.[[[[.))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))..).))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((.(((((((..[(((.((((((((.....((.....((.....((..)).....))...))......))))))...(((((((((.(......))))))))))]...))))))))))))..))..((((..(.(()).)..))))....((({..{..)))...(((((((...((([[[...(.(.(((((......(...}}...(((.((((((((((.....{.(((((.(((.)))......)))))...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((..........]]]].]]]]]................)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...(.....(((....)))...(.).......((((..)))).....)....))...(((((........)))))]]((((....(((((...(((((((....)))))))..((((....)))...(...((((((...((((((((((((((((((((((...{{{...)))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).)))..)).....((......)).)))).((((.....))))..)))....(((......(.((((..((..(....(.......(((((....(.[..).....)))))((.(((((((((((.(((((((())))))))......)))))..)))))).))(...).......(((((((((.>.(...........)...(((((((....((((.....))))......))))))).].....(((..((((((.(...(......((.(....).))......).)))))..))))).......)).))))))).)..)))..)))).)...)))))....)).[.(((.((..>].)).)))...(((((..((((.......(((((.(((((...(((((.(((((((((.((((((...))))))...(((((.....((((................(((((((((.........)))))))))..))))..)))))....)))))))))..)))))..(((.)).)((((((...........))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(..((....((....{..))....)).)(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}.....)))..)))))))..[[...((((.((((((..(.(.(.((........)).)...).)..((.....]]..))......)))))..)...)))).......((((((....))).)))...a..)..))).))))).....(.((.(.(..(((..(.(((((......(....).....))))).)(((.....((((....((.(((((((}}}.)))))..)).))...))))....))).((((...((((.....}.......))))...))))..)))...).).)).).((((((.((..((((.(..(((........(((((.(((()))).))))).......)))...(((..((((....((((.(((((((......)))))))))))...))))..)))...........)..))))..)))))))).(((((....(.......).......((.(((((((.((.....(.((.(..(((((......)))))..))).)....))....))).)))).))..))))).. Human nuclear pre-60S ribosomal subunit (State L3); 28S rRNA 8flf L4 120 2.65 RF00001 URS00000F9D45_9606 37410842 0003735 0005840 9606 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. Human nuclear pre-60S ribosomal subunit (State L3); 5S rRNA 8fmw A 1529 2.86 RF00177,RF01959,RF02542,RF01960 URS000291569B_224326 37907464 0003735 0005840 224326 aaauaacgaagaguuugauccuggcuuagaacuaacgcuggcagugcgucuuaagcaugcaagucaaacgggauguagcaauacauucaguggcgaacgggugaguaacgcguggaugaucuaccuaugagauggggauaacuauuagaaauaguagcuaauaccgaauaaggucaguuaauuuguuaauugaugaaaggaagccuuuaaagcuucgcuuguagaugagucugcgucuuauuagcuaguugguaggguaaaugccuaccaaggcaaugauaaguaaccggccugagagggugaacggucacacuggaacugagauacgguccagacuccuacgggaggcagcagcuaagaaucuuccgcaaugggcgaaagccugacggagcgacacugcgugaaugaagaaggucgaaagauuguaaaauucuuuuauaaaugaggaauaagcuuuguaggaaaugacaaagugaugacguuaauuuaugaauaagccccggcuaauuacgugccagcagccgcgguaauacguaaggggcgagcguuguucgggauuauugggcguaaagggugaguaggcggauauauaagucuaugcauaaaauaccacagcucaacuguggaccuauguuggaaacuauaugucuagagucugauagaggaaguuagaauuucugguguaaggguggaaucuguugauaucagaaagaauaccggaggcgaaggcgaacuucugggucaagacugacgcugagucacgaaagcguagggagcaaacaggauuagauacccugguagucuacgcuguaaacgaugcacacuugguguuaacuaaaaguuaguaccgaagcuaacguguuaagugugccgccuggggaguaugcucgcaagagugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugauacgcgaggaaccuuaccagggcuugacauauauaggauauaguuagagauaauuauuccccguuuggggucuauauacaggugcugcaugguugucgucagcucgugcugugagguguuggguuaagucccgcaacgagcgcaacccuuguuaucuguuaccagcauguaaugguggggacucagauaagacugccggugauaagucggaggaaggugaggaugacgucaaaucaucauggcccuuauguccugggcuacacacgugcuacaauggccuguacaaagcgaagcgaaacagugaugugaagcaaaacgcauaaagcaggucucaguccggauugaagucugaaacucgacuucaugaaguuggaaucgcuaguaaucguauaucagaaugauacggugaauacguucucgggccuuguacacaccgcccgucacaccacccgaguugaggauacccgaagcuauuauucuaacccguaagggaggaagguauuuaagguauguuuagugaggggggugaagucguaacaagguagccguacuggaaagugcggcuggauc ..........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<<<<<<....>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<<....>>>>>>......>>.>.....<<<<<<<<<....>>>>>>>>>....<<<............>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<<<<<<<.........<<<<<<<........>>>>>>>..........>>>>>>>.....<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<..<<<<<.....<<<<<<.....>>>>>>...>>>>>.>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<<..<<<......>>>.....>>>>>>>>.>..........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>...<<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>>.........<<<<<<.<<<<<<<<<<.....>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<.......<<<<<....>>>>>....<<<.....>>>...>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<......>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<.<<<<<...<<.<<<..<<<<..<<.....>>.>.>>>.>>>.>>..>>>>>.>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... ..........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((((((....))))))).)))))......(((......((((((((..((...(((((((.(.((.....((((((....))))))......)).)......((((((((....)))))))).....(.(............).).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).)))))).(((((......((((....)))).....))))....(((((....(.....(((((((........))))))).....).....))))).....)((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((.(..((((.....((((((.....))))))...)))).).))..)))))))))..(((((((((...((((((((...((((((((...((........))......))))))))...).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))..........((((((..(((((((((.....)))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((.(...(((((((....)))))))..(((.....))).).)))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..((........))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((.(((((....(.((((..((...((.....))...)).)))).)...))))).))))))..))).))))..).))...)..)..(((((((((....)))))))))..... The structure of a hibernating ribosome in the Lyme disease pathogen; 16S ribosomal RNA 8fmw X 76 2.86 RF00005 URS0002915681_224326 37907464 0030533 0006412 224326 gucgcuguagcucaguugguagagcauaggacugaaaauccuugugucaggaguucgauucuccucggcgacacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>.>....<<<<<.......>>>>>>>>>>>>.... (((((.(..((((.....[..))))..(((.........)))......(((((..]....)))))).))))).... The structure of a hibernating ribosome in the Lyme disease pathogen; E-site t-RNA 8fmw AA 2929 2.86 RF02541 URS00029156D1_224326 37907464 0003735 0005840 224326 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The structure of a hibernating ribosome in the Lyme disease pathogen; 23S ribosomal RNA 8fmw AB 112 2.86 RF00001 URS00002DD409_224326 37907464 0003735 0005840 224326 cccuggugguuaaagaaaagaggaaacaccuguuaucauuccgaacacagaaguuaagcucuuauucgcugaugguacugcgaguucgcgggagaguagguuauugccaggg .<<<<<<<<.....<<.<<<<<.....<<<<<...............>>>..>>....>>>>>..>><<<.......<<<<<....>>>>>.......>>>..>>>>>>>>. .(((((((((....((.(((((.....((((((...(.....)...))))..))....)))))..))(((.......(((((....))))).......))).))))))))). The structure of a hibernating ribosome in the Lyme disease pathogen; 5S ribosomal RNA 8fn2 A 2762 3.4 RF02541 URS00029156D1_224326 37907464 0003735 0005840 224326 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The structure of a 50S ribosomal subunit in the Lyme disease pathogen Borreliella burgdorferi; 23S ribosomal RNA 8fn2 B 112 3.4 RF00001 URS00002DD409_224326 37907464 0003735 0005840 224326 cccuggugguuaaagaaaagaggaaacaccuguuaucauuccgaacacagaaguuaagcucuuauucgcugaugguacugcgaguucgcgggagaguagguuauugccaggg <<<<<<<<<.....<<.<<<<<.....<<<<<<.............>>>>..>>....>>>>>..>><<<.....<.<<<<<....>>>>>...>...>>>..>>>>>>>>> .(((((((((....((.(((((.....((.(((...(.....)...)))...))....)))))..))(((.......(((((....))))).......))).))))))))). The structure of a 50S ribosomal subunit in the Lyme disease pathogen Borreliella burgdorferi; 5S ribosomal RNA 8fnf g 16 3.5 URS000268142F_5691 37410820 5691 uuuuuuuaaauaauuu ................ ................ Cryo-EM structure of RNase-untreated RESC-C in trypanosomal RNA editing; gRNA 8fnk m 51 3.7 37410820 5691 uauauaauagaauaagauaaguuuuuuuuuuuuuuuuuuuuuuuuuuuuuu ................................................... ................................................... Cryo-EM structure of RNase-untreated RESC-B in trypanosomal RNA editing; mRNA 8fnk g 43 3.7 URS000268144B_5691 37410820 5691 aaaaaaaaaaaaaaaaaaaaaaaaaaauuuuuuuuuuuuuuuu ........................................... ........................................... Cryo-EM structure of RNase-untreated RESC-B in trypanosomal RNA editing; gRNA 8fom QA 1500 3.58 RF00177,RF01959,RF02542,RF01960 URS000080E226_300852 36924943 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggggucuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<...>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<......>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((.(((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..)))))..))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((.(((...))).))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(.((((((..(((((((....)))))))....(((....)))...)))))).)).((.(((...((((((......(((((((((....)))...(((......)))...)))))).....((((.(((((((.......(((.....)))......))))))).....(((((....)))))........)))).......).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Crystal structure of tRNA^Lys(SUU) bound to UAA codon in the ribosomal P site; 16S rRNA 8fom QV 74 3.58 RF00005 URS00026813D3_562 36924943 0030533 562 gggucguuagcucagggnagagcaguugauunuunaucaauugnncgcaggnucgaauccugcacgacccacca <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((......))))(((((.........)))))....(((((.......)))))))))))).... Crystal structure of tRNA^Lys(SUU) bound to UAA codon in the ribosomal P site; P-site tRNA^Lys(SUU) 8fom RA 2882 3.58 RF02541 URS00001698E8_300852 36924943 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>....<<<<<.....<<....>>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<..>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<....<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.....>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<..<<<<<<<<..<<.......>>>..>>>>>>>...>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<<.....>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[[)))...].((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...((((((((.....))))))))....{.(((((((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).))))....(((((((((.[.....)))))))))....}.(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....(())...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((...(((((........))).))...)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((........((((.((...(((.........)))...)).....(...((......)).).))))....)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(..........((((..(((......((((((((....))))))))...)))............)))).).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....((((((..((..]]]]..)).)))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))...(((.....))).....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))....))) Crystal structure of tRNA^Lys(SUU) bound to UAA codon in the ribosomal P site; 23S rRNA 8fom RB 120 3.58 RF00001 URS00005F2F4B_300852 36924943 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> (((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).))))))))))) Crystal structure of tRNA^Lys(SUU) bound to UAA codon in the ribosomal P site; 5S rRNA 8fom XA 1511 3.58 RF01959,RF00177,RF02542,RF01960 URS000080E226_300852 36924943 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggggacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucaccuccuuu ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<...>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<...<<<<<<......>>>>>.>...>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<......>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<......>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.............. ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((.(.).)))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).(((.(...))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((((..(((((((....)))))))...((((....))))..))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((.......(((.....)))......))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((..........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}............. Crystal structure of tRNA^Lys(SUU) bound to UAA codon in the ribosomal P site; 16S rRNA 8fom XV 74 3.58 RF00005 URS00026813D3_562 36924943 0030533 562 gggucguuagcucagggnagagcaguugauunuunaucaauugnncgcaggnucgaauccugcacgacccacca <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((......)))).((((.........)))).....(((((.......)))))))))))).... Crystal structure of tRNA^Lys(SUU) bound to UAA codon in the ribosomal P site; P-site tRNA^Lys(SUU) 8fom XX 23 3.58 36924943 562 aaggagguagggauguaauucaa ....................... ....................... Crystal structure of tRNA^Lys(SUU) bound to UAA codon in the ribosomal P site; mRNA 8fom XY 17 3.58 RF00005 URS000080DF54_562 36924943 0030533 562 ggggauugaaaaucccc <<<<<<.....>>>>>> (((((.......))))) Crystal structure of tRNA^Lys(SUU) bound to UAA codon in the ribosomal P site; A-site ASL^Phe 8fom YA 2883 3.58 RF02541 URS00001698E8_300852 36924943 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<..>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<..>...>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<<.....>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((..)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....(..)...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((...((.((........))..))...)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......(((((.((...(((.........)))...)).....(...(........).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(....(((....)))......))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........(((((...((......((((((((....))))))))...)).............)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(..(((.....))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal structure of tRNA^Lys(SUU) bound to UAA codon in the ribosomal P site; 23S rRNA 8fom YB 120 3.58 RF00001 URS00005F2F4B_300852 36924943 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> (((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).))))))))))) Crystal structure of tRNA^Lys(SUU) bound to UAA codon in the ribosomal P site; 5S rRNA 8fon QA 1500 3.64 RF00177,RF01959,RF02542,RF01960 URS000080E226_300852 36924943 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggggucuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<...>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<.<<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>.....<......>....>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<...<<<.....>>>.>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ....((((..[..[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((.)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(.(((....)))..))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]..](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((......((((((((..(((((((....))))))).....((....))....))))))))..((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.((((((........(((.....))).......)))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.. Crystal structure of tRNA^Lys(SUU) bound to AUA codon in the ribosomal P site; 16S rRNA 8fon QV 74 3.64 RF00005 URS000077A941_562 36924943 0030533 0006412 562 gggucguuagcucaggguagagcaguugauunuunaucaauuggucgcagguucgaauccugcacgacccacca <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<.........>>>>>>>>>>>.... (((((((..((((......))))((((((.......))))))....(((.(.......).)))))))))).... Crystal structure of tRNA^Lys(SUU) bound to AUA codon in the ribosomal P site; P-site tRNA^Lys(SUU) 8fon RA 2881 3.64 RF02541 URS00001698E8_300852 36924943 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu .<<......<<<<<<<<<<<....<<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>.............>....>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<..>...>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..<<<.......>>>...>>>.......<.<<......>>.>.>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<..............<<..<<<......<<<<<<<<<..>>>>>>>>>...>>>............>>.....>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<<.....>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>. .((......((((((((((.....(((..((((((((((((......((((((.[[..[[[)))...].((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((((((((..).))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....(())...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((....((((........))).)....)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((.(........((((.(((..((.(......)))...))).....(...((......)).).))))....).)))))))).))..........]]].)....))))))))))...)))))))(((((((.......)))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((((.((((.(..........(.((..(((......((.(.(((....))).).))...)))............))..)).)))).)))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(..(((.....))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...))). Crystal structure of tRNA^Lys(SUU) bound to AUA codon in the ribosomal P site; 23S rRNA 8fon RB 120 3.64 RF00001 URS00005F2F4B_300852 36924943 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> .((((((.(((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).))).)))))). Crystal structure of tRNA^Lys(SUU) bound to AUA codon in the ribosomal P site; 5S rRNA 8fon XA 1511 3.64 RF01959,RF00177,RF02542,RF01960 URS000080E226_300852 36924943 0003735 0005840 300852 uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggggacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggaucaccuccuuu ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<...<..<<<.<<<..<<<..<<.<<<<<<<<<...>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>....<<<<.<<.<<.....>>>>.>>>>...<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<......>>>...>>>>>>>........<<<....<<<<....>>>>..>>>...>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<.<.....>>>..>>>>>>>>.<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<....>>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.............. ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((.(.).)))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.((.((.....)))).))))...(((.....))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).(((.(...))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((..(.(..(((((((....)))))))...(.((.....)))..)..).)))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((.......(((.....)))......))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}............. Crystal structure of tRNA^Lys(SUU) bound to AUA codon in the ribosomal P site; 16S rRNA 8fon XV 74 3.64 RF00005 URS000077A941_562 36924943 0030533 0006412 562 gggucguuagcucaggguagagcaguugauunuunaucaauuggucgcagguucgaauccugcacgacccacca <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((......))))((((((.......))))))....(((.(.......).)))))))))).... Crystal structure of tRNA^Lys(SUU) bound to AUA codon in the ribosomal P site; P-site tRNA^Lys(SUU) 8fon XX 23 3.64 36924943 562 ggcaaggagguaaugauauucaa ....................... ....................... Crystal structure of tRNA^Lys(SUU) bound to AUA codon in the ribosomal P site; mRNA 8fon XY 17 3.64 RF00005 URS000080DF54_562 36924943 0030533 562 ggggauugaaaaucccc <<<<<<.....>>>>>> (((((.......))))) Crystal structure of tRNA^Lys(SUU) bound to AUA codon in the ribosomal P site; A-site ASL^Phe 8fon YA 2883 3.64 RF02541 URS00001698E8_300852 36924943 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcuugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<..>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<....>>>>>>>>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<..>...>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<..<...<<<<.......>>>>...>..........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<..<<<<...........<<.<<...<<......<<<<<<<<....>>>>>>>>...>>.............>>.>>..>>>>..>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>...<<<.....>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((..)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((....))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....(())...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.(...(((((((((...(((...(((.((((...((..((......))...))...)))).)))..)).)...)))))))))..)..))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((........((((..(...((...........))...)......(...((......)).).))))....)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((.{{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((....)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((.((..(.(..((...............((....(......((((((.(....).))))))...)..............))......))...))..)).)))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.)...)))))))))))[...(((((((...((((..(.(((((.....(....)....))))).).(((((...((((...(((((((((((.}}}))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(..(((.....))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal structure of tRNA^Lys(SUU) bound to AUA codon in the ribosomal P site; 23S rRNA 8fon YB 120 3.64 RF00001 URS00005F2F4B_300852 36924943 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> .((((((.(((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((.(((((....))))).)).......))).))).)))))). Crystal structure of tRNA^Lys(SUU) bound to AUA codon in the ribosomal P site; 5S rRNA 8fr8 E 77 2.76 RF00005 URS000043C91B_246196 37216503 0030533 0006412 246196 cgcgggguggagcagcucgguagcucgcugggcucauaacccagaggucgcagguucgaauccuguccccgcuacca .........<<<<.........>>>>.<<<<........>>.>>......<<<........>.>>............ .........((((.........)))).(.((........))..)......(.(........)..)............ Structure of Mycobacterium smegmatis Rsh bound to a 70S translation initiation complex; fMet tRNA (77-MER) 8fr8 B 118 2.76 RF00001 URS00000ACC0A_246196 37216503 0003735 0005840 246196 guuacggcgguccauagcggcagggaaacgcccggucccaucccgaacccggaagcuaagccugccagcgccgaugauacuacccauccggguggaaaaguaggacaccgccgaacac <<<.<<<<<<<.....<<.<<<<<.....<<<<<...............>>>..>>....>>>>>..>>..<..<<.<..<..<<.....>>..>....>>>.>..>>>>>>>>>>.. (((.(((((((.....((..((((.....((((((...(.....)...))))..))....))))...))..(........(..((.....))..)........)..)))))))))).. Structure of Mycobacterium smegmatis Rsh bound to a 70S translation initiation complex; 5S rRNA (118-MER) 8fr8 A 3119 2.76 RF02541 URS0000D7793F_246196 37216503 0003735 0005840 246196 aaguguuuaagggcgcaugguggaugccuuggcacugggagccgaugaaggacguaggaggcugcgauaagccucggggagcugucaaccgagcguugauccgaggauguccgaauggggaaacccggcacgagugaugucgugucaccaggcgcugaauauauaggcgucuggggggaacgcggggaagugaaacaucucaguacccguaggaagagaaaacaaaaugugauuccgugaguaguggcgagcgaaagcggaggauggcuaaaccguaugcaugugauaccggguagggguugugugugcgggguugugggaccuaucuuuccggcucuaccuggcuggagggcagugagaaaauguugugguuagcggaaauggcuugggauggccugccguagacggugagagcccgguacgugaaaacccgacgucugucuugaugguguucccgaguagcagcgggcccguggaaucugcugugaaucugccgggaccacccgguaagccugaauacuucccagugaccgauagcggauuaguaccgugagggaauggugaaaaguaccccgggaggggagugaaagaguaccugaaaccgugcgcuuacaauccgucagagcccucgacgugucguggggugauggcgugccuuuugaagaaugagccugcgagucagggacaugucgcgagguuaacccgggugggguagccgcagcgaaagcgagucugaauagggcguauccacacaagagugugugguguagugguguguucuggacccgaagcggagugaucuacccauggccagggugaagcgcggguaagaccgcguggaggcccgaacccacuuagguugaagacugaggggaugagcuguggguaggggugaaaggccaaucaaacuccgugauagcugguucuccccgaaaugcauuuaggugcagcgucgcauguuucuugccggagguagagcuacuggauggccgaugggccccacaggguuacugacgucagccaaacuccgaaugccgguaaguccaagagugcggcagugagacggcgggggauaagcuccgugcgucgagagggaaacagcccagaucgccggcuaaggccccuaagcgugugcuaaguggaaaaggaugugcagucgcgaagacaaccaggagguuggcuuagaagcagccacccuugaaagagugcguaauagcucacuggucaagugauugugcgccgauaauguagcggggcucaagcacaccgccgaagccgcggcagccaacguguuggcuggguaggggagcguccugcauccggugaagccgccgagugaucgagugguggagggugugggagugagaaugcaggcaugaguagcgauuaggcaagugagaaccuugcccgccgaaagaccaaggguuccugggccaggccaguccgcccagggugagucgggaccuaaggcgaggccgacaggcguagucgauggacaacggguugauauucccguacccguguaugugcguccaugaugaaucagcgguacuaaccauccaaaaccaccgugaccgcaccuuucgggguguggcguugguggggcugcaugggaccuucguugguaguagucaagcgauggggugacgcaggaagguagccguaccggucagugguaauaccgggguaagccuguagggagucagauagguaaauccgucuggcauauauccugagaggugaugcauagccgagugaggcgaauucggugauccuaugcugccgagaaaagccucuagcgaggacauacacggcccguaccccaaaccaacacagguggucagguagagaauacuaaggcguacgagugaacuaugguuaaggaacucggcaaaaugcccccguaacuucgggagaagggggacccacauggcguguaagccuuuacggcccaagcgugaguggguggcacaaaccagugagaagcgacuguuuacuaaaaacacagguccgugcgaagucgcaagacgauguauacggacugacgccugcccggugcuggaagguuaagaggacccguuaacucccuuugggggugaagcggagaauuuaagccccaguaaacggcggugguaacuauaaccauccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaacgacuucucaacugucucaaccauagacucggcgaaauugcacuacgaguaaagaugcucguuacgcgcggcaggacgaaaagaccccgggaccuucacuacaacuugguauuggugcucgauacgguuuguguaggauaggugggagacugugaagcucacacgccaguguggguggagucguuguugaaauaccacucugaucguauugggccucuaaccucggaccguauauccgguucagggacagugccugguggguaguuuaacuggggcgguugccuccuaaaauguaacggaggcgcccaaagguucccucaaccuggacggcaaucagguguugaguguaagugcacaagggagcuugacugcgagacggacaugucgagcagggacgaaagucgggacuagugauccggcaccucugaguggaaggggugucgcucaacggauaaaagguaccccggggauaacaggcugaucuuccccaagaguccauaucgacgggaugguuuggcaccucgaugucggcucgucgcauccuggggcuggagcaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguuuagaacgucgugagacaguucggucucuauccgccgcgcgcgucagaagcuugaggaaaccugucccuaguacgagaggaccgggacggacgaaccucugguauaccaguugucccaccaggggcacggcuggauagccacguucggacaggauaaccgcugaaagcaucuaagcgggaaaccucuuccaagaccaggcuucucacccucuaggagggauaaggccccccgcagaccacgggauugauagaccagaccuggaagccuaguaauaggugcagggaacuggcacuaaccggccgaaaacuuac <<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<<......<<<<<<.[[.(((.>>>.....<<<<<<<..<<<)))..]].>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<.....>>..<<<<<<.....<<.....>>....>>>>>>...<<<....<<<<<<<<<<.........(((((.....>>>>>>>>>>......<<<<..<.....<<<<<<<))))).>>>>>>><<<<<<.......<<<<<<.<<<<.<<<.....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>>>.....>...>>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..>>>......>>.>>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<<<<..>>>>.>>>>>..>>>>...<.<........>.>.<<<<<<....<<<.<<<<<<<<<<..<<<...<<<....>>>...>>>...<<....>>..<<<<.....>>>>....<<<<<<<....>>>>>>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<....<<<<<<<<.....<<<....<<<.<<<<....<<<<<<....>>>>>.>....>>>>.>>>..>>.>.....>>>>>>>>.......>>>>>>>.>>..<<<<<<<<<<......>>>>>>.>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<.........>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>...........)))......>>>>>>.>>>...>>>>>>><<<<<<<<..>>>>>>>>....>>>>>><.<<<<<<<<<<......<<<<<<<<....>>>.>>>>>...>>>>>>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<.......<<<<...<<<<<<<......<<<<.<....<<<<<....<<<<<<<<....>>>>>>>>....>>>>>....>.>>>>.....>>>>>>>.....>>>>.<<...<<<<<...<<<<..<<<..<<<<..<<<<<...((((...>>>>>.<<..<<<<...<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>...>>>>...>>...<<<......>>>.....>>>>...>>>...>>>>........>>>>>..>>....>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<<...<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<...<<<<....<<<.....>>>....>>>>..>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<....<<<<..<<<<<<...>>>>>>...>>>>....>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>>>>>>>>.....>.((..<<<<<......))>>>>>..<<<<<<<<.<<<.<<......<<<<<<<<<<..<<<<<.<<<.<<<<<.<<.<<<<<<<<<<<<<............<<<<..<<.......<<<<<<<<....>>>>>>>>....>>............>>>>...>>>>>>>>>>>>>.>>...<<<.<<<<<<......>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.<<..>>>>..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<.<<<<...<<.......>>...>>>>.>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))))>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<...>>>>>....<<<<.<<<<.......>>>>.....<<<.<<<<.<<<....<<<<<....>>>>>...>>>..>>>>..>>>...>>>>....>>>>.. ((((......((((((((((.....(((..(((((((((((((......((((((.[[.[[[.))).....((((((...(((]]]..]].)))......))))))...)))....(((....)))(((((((......))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))....((([...((((((((((.........[[[[[.....))))))))))....(.((((..(.....((((((.]]]]]..)))))).(((((.......((((.(.((((.(((...(.((((......)))))[[(...).(((.....]])))...)))...))))).)))))))))......)...))))]....(((((((...[.......)))))))....).(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((..(((((((((..)))).)))))..)))).<.(.(........).).((((((..(.(((.((((((((((..(((...(((....)))...)))...((....))..((((.....))))....(((((((....)))))))....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......A))))))))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))(((((((((.([.((((((((.....(((....(((.((((....((((((....))))).)....)))).)))..)).).....))))))))....).]))))))).))..((((((((((......)))))).))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.((([.(((.........)))..))).....(]..((......)).).)))))...)))))))))).))...........]]].)....))))))))))...)))))))((((((((..))))))))....))))))((((((((((((......((((((((....))).)))))...)))))))))).)).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]]((((((((((.(.....((((....((((((......((((.((...((((((...((.((((......)))).))..).)))))...)).)))).....))))).).....)))).((...(((((...((((..(((..((((..(((((....{{....))))).((..(((....(((((((((((.((.....))))))))).....))))..[.)))...))...(((......))).....))))...)))...))))(..)....)))))..))..).)))))))))))))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((...((((....((((..)])))....))))..))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((....((((..((((((...))))))...))))....))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....))[[..(((((.....>]])))))..((((((((.(((.((......((((((((((..(((((.(((.(((((.((.((((((((((((..(......[...((((..((.......((((((((....))))))))....))....].......)))).)..)))))))))))).))...(((.((((((......)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.(.((((...((.......))...)))).)...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))..a.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..(((((...)))))....((((.((((.......)))).....(((.((((.(((....(((((....)))))...)))..))))..)))...))))....)))).. Structure of Mycobacterium smegmatis Rsh bound to a 70S translation initiation complex; 23S rRNA (3119-MER) 8fr8 a 1511 2.76 RF00177,RF01959,RF02542,RF01960 URS0000D7794D_246196 37216503 0003735 0005840 246196 uuuggagaguuugauccuggcucaggacgaacgcuggcggcgugcuuaacacaugcaagucgaacggaaaggcccuuucggggguacucgaguggcgaacgggugaguaacacgugggugaucugcccugcacuuugggauaagccugggaaacugggucuaauaccgaauacacccugcuggucgcauggccugguaggggaaagcuuuugcggugugggaugggcccgcggccuaucagcuuguugguggggugauggccuaccaaggcgacgacggguagccggccugagagggugaccggccacacugggacugagauacggcccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagcgacgccgcgugagggaugacggccuucggguuguaaaccucuuucagcacagacgaagcgcaagugacgguaugugcagaagaaggaccggccaacuacgugccagcagccgcgguaauacguaggguccgagcguuguccggaauuacugggcguaaagagcucguaggugguuugucgcguuguucgugaaaacucacagcuuaacugugggcgugcgggcgauacgggcagacuagaguacugcaggggagacuggaauuccugguguagcgguggaaugcgcagauaucaggaggaacaccgguggcgaaggcgggucucugggcaguaacugacgcugaggagcgaaagcguggggagcgaacaggauuagauacccugguaguccacgccguaaacgguggguacuagguguggguuuccuuccuugggauccgugccguagcuaacgcauuaaguaccccgccuggggaguacggccgcaaggcuaaaacucaaaggaauugacgggggcccgcacaagcggcggagcauguggauuaauucgaugcaacgcgaagaaccuuaccuggguuugacaugcacaggacgccggcagagaugucgguucccuuguggccugugugcagguggugcauggcugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuugucucauguugccagcacguuaugguggggacucgugagagacugccggggucaacucggaggaagguggggaugacgucaagucaucaugccccuuauguccagggcuucacacaugcuacaauggccgguacaaagggcugcgaugccgugagguggagcgaauccuuucaaagccggucucaguucggaucggggucugcaacucgaccccgugaagucggagucgcuaguaaucgcagaucagcaacgcugcggugaauacguucccgggccuuguacacaccgcccgucacgucaugaaagucgguaacacccgaagccgguggccuaacccuuguggagggagccgucgaaggugggaucggcgauugggacgaagucguaacaagguagccguaccggaaggugcggcuggauc ......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<..<<<<<<<....>>>>>.>>>..>>>>>......<<........<<<<<<<..<<...<<<<<<<<<<<<.....<<<<<<....>>>>>>......>>>>.....<<<<<<<<<<<<..>>>>>.>>>>>>>....<<....>>>>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<<....>>.......>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<.....<<<<<<<.....>>>>>>>...>>>>>>>..>>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<<..<<<......>>>.....>>>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<.......>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<...<<..<<<<<<<....>>>>>>>.<<.....>>>>...>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<<..<<<......>>>>>.....>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>......>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<..<<<<....<.<<<<..<<<..<<.....>>.>>>.>>>>.>...>>>>..>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... ......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((....))))).)))..)))))......(((.......(((((((..((...((((((((((((.....((((((....))))))......)))).....(((((((((((....)))).)))))))....((....))))))))))..))))))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(..((....))..)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((.....(((((((.....)))))))...))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.......))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((...((..(((((((....))))))).((.....))))...)))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((......)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((...(((....)))...))....)))......)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((..((((....(.((((..(((..(((..).)).))).)))).)...))))..))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Structure of Mycobacterium smegmatis Rsh bound to a 70S translation initiation complex; 16S rRNA (1511-MER) 8fr8 v 18 2.76 37216503 246196 aggagguaaaaauguuca .................. .................. Structure of Mycobacterium smegmatis Rsh bound to a 70S translation initiation complex; mRNA 8fru 3 117 2.49 RF00001 URS000007DE0E_941442 38242118 0003735 0005840 941442 aguucggccauccuacggcggaaacuccuuaacucguuccgaauuaagaagagaagcgccgucaggccccgccaguacugcgaucggagacgucgugggaacacggggugccgaacu <<<<<<<<....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>><<<<<<......<<<<<<.<<....>>>>>>>>.....>>>>>>>>>>>>>> ((((((((....((((((((.....((((((...(.....)...))))..))....)))))).))((((((......((((((.((....)))))))).....)))))))))))))) 60S subunit of the Giardia lamblia 80S ribosome; 5S rRNA 8fru 4 141 2.49 URS000291567D_941442 38242118 941442 aacgccccgccggcggaugccucggcccgggcggcgacgaagagcgcggcggagcgcgagacgcggugcggacccgcccgccccgagaagcaccggcccucgaacgcagcgcgccccggcgccgccgccucggugcccugc .........................................<<<<<<.((.....>>>.....<<<<<<...<..))..>.........>>>>>>...>>>....<<...>><<....>>..................... .........................................((((((.[[.....))).....((((((...(..]]..).........))))))...)))....((...))((....))..................... 60S subunit of the Giardia lamblia 80S ribosome; 5.8S rRNA 8fru 1 2551 2.49 RF02543 URS0002915677_941442 38242118 0003735 0005840 941442 cgcggcccgaggcggcgggggcgacgggcggaacuuaagcauaucaguacgccccggaggagaaaccaaccgggauuccccguagcggcgagcgacgcgggaggagcccgccccgaaggcgcgcuguggggcgcaccgccgcgagggggcccgagggccccgcccgagagggugcaagccccguacggcgggcggcgaguagcgcugcuugagcgugcagcgcgaagggaggcgcggcccuuccaaggcuaaauacgccccgggaccgauagcggaccaaguagcgcgagcgaacggugaaaaggacgcccugcggccgcucaaaagaccugaacccggccggccgccggcccgccggccccgucucgaaacacggaccgaggagccacgcgccgcggcgagcccgagggagcccccgcggcggagcgagcgcgagacgccccgggcccgccaugccccugcgggcgugcgcgggccgagccgcggcgcgugggcccgaaaggcggugaucuaugcccggcgagggcgaggccgggcgaaagccugguggaggcccgccgcggugcugacgcgcagaucgcucgucggagccgggcaugggggcgaaagacucaucgaaccgccugguagcugguugccuccgaaaugucucccaggacagccgccgccccgcaguugcggcccguagagcgcuggccggcgggagcggggccucgcccgccccccaaacuccgaagggccgcgccgccccgccgcuggccugggcggggcgggcgaaugcgggcggcgcgugggccccuccugguaagcaggacgggcgaggcgggacgauccggacgccgggccagggugcgccgccggggcccgcggaacggcgucggccggucccgacagcagccgaaucggccggcccggaaaauggagcgcgccggagccccggacccgcgcccggccgccgcgcgcggcggguaggaggccgcagaggccccgggggcgaaggcggcgcgcaggccccgccggaccggccucuggugcagaucucggcagcaguagccgcuacuccgcgccccggaggacugagggggagacggguuccgcggcgccugcaucuggccgcgggugacucgggccuaagcggcgggugaagaccgggaaggggcgugcccgcccgucgaacggggagccggcggagacuccggcaggcgcggcccccgcggagacgcccgccccccggcgacgcgcacggggaccgcggcgggcggcgccccggcccgcgaacgccccgcagcccccggacgccuugcgcggagaggggggcccgggggcggaccccgcgcguccccggccgccccugaaaagccggggggcgccggccgcgcgccguaccgaccgcagcaggacuccggggucagcagccucuagcgcgggagcgaacgcggcucagggaagucggcaagccggcuccguaaccucgggaaaaggaguggcucugacggccgggucagaacuggaacggacgcggggaucccgacuguuuacuagaaacacagcgucgcgagggccgcacccggcgcuggcgcgacgugauuucugcccagugccacgaccgucaccgugaagcgauccgccgaagcccugguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucgggcaauuuccgacgugcaugaauggaccaacgaggaucccacugucccgagccgcgccuccgcgagccuccagccucgggaacgggcgagggccggccagcggggcaagaagacccuuuugagcuugacuccagcccgggccuguggggcgggggccgccgccgccccgcucacccggucgcgcggggacccgcccgggcggggaguucggcuggggcggcgcgccugcuacaccggaccgcaggcgucccacggcgggcucagcgaggacggagaccucccgcggagcagaagggcacaagcccgcccgacccgcgccccccgugccggcgcgggccgcgaaagcggggccuaccgauccuucgccgccccggccgcgggcgcggagguggcagaaaaguuaccacagggauaacuggcuuguggccgccgagcgcccgcagcgacgcggcuuuuugauccuucgaugucggcucuuccuaccguccgcgcgcaccggcgcggaagcgucggauuguucacccguucaagggaucgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacuggccccggggccagagcacggcgggccaguacgagaggaacgcccgccgcgggccgccagccccgcgguugcccggccgggcagcgccgcgccgccgcgcccgggggcccugcgcugaccgccucuaagcgcgcaccccgccucgcgccccgcccggccgcgcgccccagccccgugccccgucgccgagcggcccccgcccggggagaccacccggcgcggcgcuccuguacggcgcagagcccugcgaucgccugagggacgcgccugcagagcgc ........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<....<<.....>>.....>>>>>..[[[...<<<.............>>><<...<<<<<<....<<<<<......>>>>>((......<<<.....))>>>...>>>>>>>>........<<<<<<<........>>>>>>>...(((((..<<<<<<)))))..]]]..................................<<....>>................<<<....>>>............................<<<<<<..>>>>>>.<<<<........>>>>.<<<<<....<<<<<<<<<<<<<..<<<...<<<....>>>..>>>...<<....>>............<<<<<<<<<<<<<....>>>>>>>.>>>>>>...>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<<.<<<.<<<<<<<<<...<<<...<<<..<<<<<..<<<<<..>>>>>>>>>>..>>>..>>.>...>>>>>>>.<<<<<<<<<<.........>>>>>>>>>>...>>>>>>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((...<<<<<<<........<<<.<<<<<<<<<.................>>>>>>>>>>>>..........)))......>>>>>>>>>>>..>>>>>>><<<<<....>>>>>....>>>>>><<<<<<<<<<...<<......<<<<<.<<....>>.>>>>>...>>>>>>>>>>.>>.....>>>>>.<<.....<<.....<<<<<.....>>>>>..<<.....<<<<..<<...<<<<<<...<.......>.>>>>>>....((<<<.<<...<<<...<<<....>>>......<<<<..>>>>...>>.>....>>...<<<<<........>>>>>))<<<<<<<<...<<<....>>>..<<<<<<<<<<...<<<..<<<<<<<<<<<<<<<<<...{{{...>>>>>....<<<<<<...<<<<<<....<<.....>>......>>>>>>...>>>>>>....>>>>>.>>>>>>>..>>>.........>>>>>>>>>>...>>>>>>>>.>>>..>>..<<......>>.>>>>.<<<<.....>>>>..>>....<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<......>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<....>>>>......>>>>>>>...<<..<<<..<<<<<<.<...<<....<<<.<....>.>>>....>>.>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>....>>....<<<<<........>>>>>...((((((..{{{.........{{{..{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<.........>>>>>>>>>...<<<<......>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<.<<<<.......>>>>.>.....<<...(((>>....>>>>>>>...<<<<<<<<.........>>>>>>>>.<<<....>>>.>>))).......(((((.(((((.>>>>>>))))))))))..........]]]]..}}.}}}.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<.........>>>....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........}}}.))))))..<<<<<..<<<..<<<<<<<<...............>>>>>>>><<<<<...<.<<...<<<<<<<<<<}}}.>>>>>..>>>>>...>>.>.>>>>>.<<<...<<<<<<...........>>>>>>...>>>..>>>..>>>>>....<<<<<<............................>>>>>>.....<<<<<.......>>>>..<<<<<<<<<<<....<<<<.<..<<...>>..>>>>>...>>>>.>>>>>.>>...>... ........................((((((.....(...[..)......))))).).........((....))...((((....((.]...)).....))))...((((..(((..((...)....))))((...(((((.....(((((......)))))[[(...).(((.....]])))....)))))))...)....(((((((........)))))))...(((((..[[[[[[)))))..)))..................................((....))............(...(((....)))...........)................((((((..))))))[((((........)))).(((((..(.(((((((((((((..((....(((....)))...))...((....))....(......)(((((((((((((....))))))).))))))...)))))))))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))).((((((....(((((....)))))((((((((((.(((.(((((((((...(((...(((..(((((..(((((()))))))))))..)))..)).)...))))))).((((((((((.(......)))))))))))...))))))))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(((((((........(((.((((((((((.......(...)...)))))))))))))..........]]]......))))))))))...)))))))(((((....)))))....))))))(.((((((((...((......(((((.((....)).)))))...))))))))))..).....))))).((.....((.....(((((.....)))))..((.....((((..((..(((((((...(.......).)))))).....[(((.((...(((...(((....))).(....((((..)))).).)).)....))...(((((........)))))].((((((((...(((....)))..((((((((((...(((..(((((((((((((((((...{{{...)))))....((((((...((((((...(((.....))).....))))))...))))))....))))).)))))))..)))(...)....))))))))))...)))))))).))).)))..((......)).)))).((((.....))))..))....((((....((((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((..)..)))))).))(...).......(((((((((.].((.........))...(((((((....((((....))))......))))))).}.(((.(((..((((((.(...((....(((.(....).)))....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)).{..(((((.....]}.)))))...((((((..(((.((......(((..((((((..(((((.((((((((..((((((((((.....)..)))))))))...((((......)))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.(.((((.......)))).)...).((][.[[[))....))))))).(.((((((((.....{...)))))))))(((....))).))]]].].....(((((.(((((.]]]]]]))))))))))....)}....))))..)).))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(((((((((......))))))..))).(((.(.....).)))....)))))..)...))).).....(((((((....))).))))..>.))..))).))))))..(((((..(((..((((((((.....(....)....))))))))(((((...(.((...((((((((((}}}.)))))..)))))...)).).))))).(((....((((.............))))....)))..)))..)))))(...((((((........(..)................))))))..)..(((((.......))))..(((((((((((....((((.(..((...))..)))))...)))).))))).))...)... 60S subunit of the Giardia lamblia 80S ribosome; 28S rRNA 8fto A 1519 1.85 RF00177,RF01959,RF02542,RF01960 URS00000ABFE9_562 37419664 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugccggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<......>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<.>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<.......<<<....>>>......>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<..>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((.(((((......)))))..)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((.)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[....((((.....((.]]])).......)))).)))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((((())))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))....(.....)..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... E. coli 70S ribosome with an improved MS2 tag inserted in H98; 16S rRNA 8fto Z 76 1.85 RF00005 URS00002905B5_562 37419664 0030533 0006412 562 gcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaaccn <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((.........)))).(((((.......))))).....(((((.......)))))))))))..... E. coli 70S ribosome with an improved MS2 tag inserted in H98; P-site tRNA-fMet 8fto a 2767 1.85 RF02541 URS0002681457_562 37419664 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagcgucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcgcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccugaucauuuuuuugaucaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<...........>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<..>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<..>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<..<<....>>...>>>>>..>....>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<..>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<<<<<<<......>>>>>>.>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((........(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))))))))))).....))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((...((.....))....))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{........)))..))))).))...........]]].)...))))))))))...)))))))((((((((()))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((())))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((((((((......)))))).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). E. coli 70S ribosome with an improved MS2 tag inserted in H98; 23S rRNA 8fto b 119 1.85 RF00001 URS0000049E57_562 37419664 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>> ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))) E. coli 70S ribosome with an improved MS2 tag inserted in H98; 5S rRNA 8fvi B 10 3.24 URS000268147F_562 37640699 562 auuuuuuuuu .......... .......... Human APOBEC3H bound to HIV-1 Vif in complex with CBF-beta, ELOB, ELOC, and CUL5; RNA(5'-R(AP*UP*UP*UP*UP*UP*UP*UP*UP*U)-3') 8fvy g 74 2.94 RF00005 URS00029156E7_941442 38242118 0030533 0006412 941442 ggguaauuggcgcaguugguuagcgcgcgggucucauaaucccgagcucgugaguucgauccgcacauucccca <<<<.....<<...........>><.<............>.>....<..<<.......>>..>...>>>>.... (..(.....((...........))(................)....(...(.......)...)...)..).... 40S subunit of the Giardia lamblia 80S ribosome; tRNA 8fzd a 1528 3.1 RF00177,RF01959,RF02542,RF01960 URS00000ABFE9_562 39030416 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugccggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<........>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>...<.<<<<<.......<<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<..>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>.............>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((((..........)))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((((.......)))))))).....)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((((())))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((.(((....))).)))....(.....)..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Cryo-EM structure of an E. coli non-rotated ribosome termination complex bound with apoRF3, RF1, P- and E-site tRNAPhe (Composite state I-B); 16S Ribosomal RNA 8fzd x 76 3.1 RF00005 39030416 0030533 562 gcccgganagcucagucgguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((.........)))).....(((((..]....)))))))))))).... Cryo-EM structure of an E. coli non-rotated ribosome termination complex bound with apoRF3, RF1, P- and E-site tRNAPhe (Composite state I-B); P-site phenylalanyl-tRNA 8fzd y 74 3.1 RF00005 39030416 0030533 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[..)))).((((.........)))).....((.((..]....)).))))))))).... Cryo-EM structure of an E. coli non-rotated ribosome termination complex bound with apoRF3, RF1, P- and E-site tRNAPhe (Composite state I-B); P-site phenylalanyl-tRNA 8fzd z 10 3.1 39030416 2681598 aaauucuaau .......... .......... Cryo-EM structure of an E. coli non-rotated ribosome termination complex bound with apoRF3, RF1, P- and E-site tRNAPhe (Composite state I-B); F-UAA mRNA 8fzd A 2899 3.1 RF02541 39030416 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcgcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<.....<<.......>>.....>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<..>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<....<<..>>.....>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.......<<<<<<.<<....>>..>>>>>>.......>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<....<<.......<<<<.<<<....>>>.>>>>....>>..............>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((........)))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((..(((.....)))...))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.((.....................)).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((((()))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...(((.((((((((.((.....))))))))))...)))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((.((...(((...........(...(...(.........((..((....))..))......)......(..)...)...)..)))...)).)))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Cryo-EM structure of an E. coli non-rotated ribosome termination complex bound with apoRF3, RF1, P- and E-site tRNAPhe (Composite state I-B); 23S Ribosomal RNA 8fzd B 120 3.1 RF00001 URS00005C6868_562 39030416 0003735 0005840 562 ugccuggcggcaguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Cryo-EM structure of an E. coli non-rotated ribosome termination complex bound with apoRF3, RF1, P- and E-site tRNAPhe (Composite state I-B); 5S Ribosomal RNA 8fze a 1528 3.0 RF00177,RF01959,RF02542,RF01960 URS00000ABFE9_562 39030416 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugccggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<........>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<..>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((((..........)))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((((.......)))))))).....)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((.(((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))..))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((((())))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((.(((....))).)))....(.....)..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Cryo-EM structure of an E. coli non-rotated ribosome termination complex bound with RF1, P- and E-site tRNAPhe (State I-A); 16S Ribosomal RNA 8fze x 76 3.0 RF00005 39030416 0030533 562 gcccgganagcucagucgguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((.........)))).....(((((..]....)))))))))))).... Cryo-EM structure of an E. coli non-rotated ribosome termination complex bound with RF1, P- and E-site tRNAPhe (State I-A); P-site phenylalanyl-tRNA 8fze y 74 3.0 RF00005 39030416 0030533 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<......>>>>.<<<<.........>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[..)))).((((.........)))).....(((((..]....)))))))))))).... Cryo-EM structure of an E. coli non-rotated ribosome termination complex bound with RF1, P- and E-site tRNAPhe (State I-A); P-site phenylalanyl-tRNA 8fze z 10 3.0 39030416 2681598 aaauucuaau .......... .......... Cryo-EM structure of an E. coli non-rotated ribosome termination complex bound with RF1, P- and E-site tRNAPhe (State I-A); F-UAA mRNA 8fze A 2899 3.0 RF02541 39030416 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcgcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<.....<<.......>>.....>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<..>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<<.<<....>>..>>>>>>..>....>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<..<<<<...........<<.<....<<......<<<<<<<<....>>>>>>>>...>>..............>.>>..>>>>..>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......((((.((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))).))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((........)))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..(((.((((((.....(((...(((.((((...((.((((.....))))..))...)))).)))..)).).....))))))..))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.((.....................)).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((((()))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]]((((((((((.((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...)).....)))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((....(((....])))....)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((.(...((((...........(...(...(.........(..(((....)))..)......).............)...)..))))...).)))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Cryo-EM structure of an E. coli non-rotated ribosome termination complex bound with RF1, P- and E-site tRNAPhe (State I-A); 23S Ribosomal RNA 8fze B 120 3.0 RF00001 URS00005C6868_562 39030416 0003735 0005840 562 ugccuggcggcaguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Cryo-EM structure of an E. coli non-rotated ribosome termination complex bound with RF1, P- and E-site tRNAPhe (State I-A); 5S Ribosomal RNA 8fzf a 1528 3.2 RF00177,RF01959,RF02542,RF01960 URS00000ABFE9_562 39030416 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugccggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<.<<<<........>>>>..>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.<...>.>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<..>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>.............>>>>>.>>.<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((..((..........))...)))))..)))))......(((.......((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....))).....(((((..((....)))))))..)))))))..)).)))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(...(((((((((.......)))))))).)...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(.(((((.((((((((((......((((((.....))))))....))))))))..))))))).)..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((((())))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((....(((((....)))).)..............))))).))).((.(((....(((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)..)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Cryo-EM structure of an E. coli rotated ribosome complex bound with RF3-ppGpp and p/E-tRNAPhe (Composite state I-C); 16S Ribosomal RNA 8fzf x 74 3.2 RF00005 39030416 0030533 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<.................<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((.....[....)).((((.........)))).....(((((..]....)))))))))))).... Cryo-EM structure of an E. coli rotated ribosome complex bound with RF3-ppGpp and p/E-tRNAPhe (Composite state I-C); p/E phenylalanyl-tRNA 8fzf A 2899 3.2 RF02541 39030416 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcgcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<.....<<.......>>.....>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<..>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>.>........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<....<<..>>.....>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.......<<<<<<.<<....>>..>>>>>>.......>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<.<<<<<..............<<..<<.......<<<<<<<<....>>>>>>>>....>>............>>.....>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......((((.(((((.((.(((...(((((......)))))[[(...).(((.....]])))...)))...)).))))).))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((........)))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.((.......))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...((..((((...(.(.(((.....)))...))...))))..))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.((......(........).....).)....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((((()))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........((.((..((....))...)).))........))))))))..)))))(.(((.........))).)........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((..(((((...........(...(...(........((..(((....)))..)).....).............)...)..)))).).)))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Cryo-EM structure of an E. coli rotated ribosome complex bound with RF3-ppGpp and p/E-tRNAPhe (Composite state I-C); 23S Ribosomal RNA 8fzf B 120 3.2 RF00001 URS00005C6868_562 39030416 0003735 0005840 562 ugccuggcggcaguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Cryo-EM structure of an E. coli rotated ribosome complex bound with RF3-ppGpp and p/E-tRNAPhe (Composite state I-C); 5S Ribosomal RNA 8fzg a 1528 3.1 RF00177,RF01959,RF02542,RF01960 URS00000ABFE9_562 39030416 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugccggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<..........>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>...<.<<<<<.......<<<<<<<<<.<...>.>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<..>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>.............>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((((..........)))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((((.......)))))))).....)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((((())))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((.(((....))).))).............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Cryo-EM structure of an E. coli non-rotated ribosome termination complex bound with RF3-GDPCP, RF1, P- and E-site tRNAPhe (Composite state II-A); 16S Ribosomal RNA 8fzg x 76 3.1 RF00005 39030416 0030533 562 gcccgganagcucagucgguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((.........)))).....(((((..]....)))))))))))).... Cryo-EM structure of an E. coli non-rotated ribosome termination complex bound with RF3-GDPCP, RF1, P- and E-site tRNAPhe (Composite state II-A); P-site phenylalanyl-tRNA 8fzg y 74 3.1 RF00005 39030416 0030533 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[..)))).((((.........)))).....((.((..]....)).))))))))).... Cryo-EM structure of an E. coli non-rotated ribosome termination complex bound with RF3-GDPCP, RF1, P- and E-site tRNAPhe (Composite state II-A); P-site phenylalanyl-tRNA 8fzg z 11 3.1 39030416 2681598 aaauucuaaua ........... ........... Cryo-EM structure of an E. coli non-rotated ribosome termination complex bound with RF3-GDPCP, RF1, P- and E-site tRNAPhe (Composite state II-A); F-UAA mRNA 8fzg A 2899 3.1 RF02541 39030416 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcgcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<.....<<.......>>.....>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<..>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>.>........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.......<<<<<<.<<....>>..>>>>>>.......>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<<<<<...<<......<<<<<<<<....>>>>>>>>...>>.............>>>>>...>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((.((((((.((.(((...(((((......)))))[[(...).(((.....]])))...)))...)).)))))).)))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((........)))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((.(((.....))).).))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.((.....................)).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((((()))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........((((...((....))....))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((.(.((((...........(((.(...((........((((((....)))))).....))......(..)...).)))..)))).).)))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Cryo-EM structure of an E. coli non-rotated ribosome termination complex bound with RF3-GDPCP, RF1, P- and E-site tRNAPhe (Composite state II-A); 23S Ribosomal RNA 8fzg B 120 3.1 RF00001 URS00005C6868_562 39030416 0003735 0005840 562 ugccuggcggcaguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Cryo-EM structure of an E. coli non-rotated ribosome termination complex bound with RF3-GDPCP, RF1, P- and E-site tRNAPhe (Composite state II-A); 5S Ribosomal RNA 8fzh a 1528 2.9 RF00177,RF01959,RF02542,RF01960 URS00000ABFE9_562 39030416 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugccggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<........>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<..>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>....<....>...>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((.(((..........)))..)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((((())))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...((.(((....))).)).....(.....)..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Cryo-EM structure of an E. coli non-rotated ribosome termination complex bound with RF1, P- and E-site tRNAPhe (State II-D); 16S Ribosomal RNA 8fzh x 76 2.9 RF00005 39030416 0030533 562 gcccgganagcucagucgguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((.........)))).....(((((..]....)))))))))))).... Cryo-EM structure of an E. coli non-rotated ribosome termination complex bound with RF1, P- and E-site tRNAPhe (State II-D); P-site phenylalanyl-tRNA 8fzh y 74 2.9 RF00005 39030416 0030533 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<......>>>>.<<<<.........>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[..)))).((((.........)))).....((.((..]....)).))))))))).... Cryo-EM structure of an E. coli non-rotated ribosome termination complex bound with RF1, P- and E-site tRNAPhe (State II-D); P-site phenylalanyl-tRNA 8fzh z 11 2.9 39030416 2681598 aaauucuaaua ........... ........... Cryo-EM structure of an E. coli non-rotated ribosome termination complex bound with RF1, P- and E-site tRNAPhe (State II-D); F-UAA mRNA 8fzh A 2899 2.9 RF02541 39030416 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcgcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<.....<.........>.....>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<..>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<....<<..>>.....>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<<.<<....>>..>>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<.....<<......<<<<.<<<....>>>.>>>>...>>...............>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......((((.(((((.((.(((...(((((......)))))[[(...).(((.....]])))...)))...)).))))).))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((((..)))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((........)))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((.((((.....))))..))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.((.....................)).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((((()))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((....(((....])))....)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((.(((.((((...........(...(...(.........(...(......)...)......).............)...)..)))).))).)))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Cryo-EM structure of an E. coli non-rotated ribosome termination complex bound with RF1, P- and E-site tRNAPhe (State II-D); 23S Ribosomal RNA 8fzh B 120 2.9 RF00001 URS00005C6868_562 39030416 0003735 0005840 562 ugccuggcggcaguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Cryo-EM structure of an E. coli non-rotated ribosome termination complex bound with RF1, P- and E-site tRNAPhe (State II-D); 5S Ribosomal RNA 8fzi a 1528 3.1 RF00177,RF01959,RF02542,RF01960 URS00000ABFE9_562 39030416 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugccggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<........>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<.......<<<<..>>>>......>>>>...<.<<<<<.......<<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<..>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>.............>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<..<.<<<<<<<........>>>>>>>>...>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<..<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>..>>>>..>>.>>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((.(((..........)))..)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(...(((((((((.......)))))))).)...)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((((())))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(.(((((....)))).)).............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((....(((((....((((((.((((..((....)).))))))))))...)))))....)))..))).))))..).))...)..)..(((((((((....)))))))))}..... Cryo-EM structure of an E. coli rotated ribosome bound with RF3-GDPCP and p/E-tRNAPhe (Composite state II-B); 16S Ribosomal RNA 8fzi x 74 3.1 RF00005 39030416 0030533 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<......>>>><<<<<<<.....>>>>>>.>...<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[..)))).((((.........)))).....((.((..]....)).))))))))).... Cryo-EM structure of an E. coli rotated ribosome bound with RF3-GDPCP and p/E-tRNAPhe (Composite state II-B); p/E phenylalanyl-tRNA 8fzi A 2899 3.1 RF02541 39030416 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcgcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<....<.<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>..>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<........>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<.....<<.......>>.....>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<..>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<....<<..>>.....>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.......<<<<<<.<<....>>..>>>>>>.......>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<..<<<............<<......<<......<<<<.<<<....>>>.>>>>...>>................>>...>>>..>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((.(((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))))))).)))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((..........))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...((..((((...((.((((.....))))..))...))))..))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.((.....................).)....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((((()))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((((.((..(.(((.(.........(...(...(........((.(.(......).).)).....).............)...)).)))..).)).))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Cryo-EM structure of an E. coli rotated ribosome bound with RF3-GDPCP and p/E-tRNAPhe (Composite state II-B); 23S Ribosomal RNA 8fzi B 120 3.1 RF00001 URS00005C6868_562 39030416 0003735 0005840 562 ugccuggcggcaguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((.(((((....(((((((...(.....)...))))..)))...)))))..)).((.......((((((((...)))))))).......))...)))))))))). Cryo-EM structure of an E. coli rotated ribosome bound with RF3-GDPCP and p/E-tRNAPhe (Composite state II-B); 5S Ribosomal RNA 8fzj a 1528 3.0 RF00177,RF01959,RF02542,RF01960 URS00000ABFE9_562 39030416 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugccggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<........>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>.....<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>.......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<..>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<.<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>.>>>..>>.>>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((.(((..........)))..)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..(((.......((((....))))......)))...(.(((((...(....((((((((.......)))))))).....)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((((())))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((....(.(((....)))..)..............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..((.......))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((..(..((((....(((.((.((((..((....)).)))))).)))...))))..)..)))..))).))))..).))...)..)..(((((((((....)))))))))}..... Cryo-EM structure of an E. coli rotated ribosome bound with RF3-GDPCP and p/E-tRNAPhe (Composite state II-C); 16S Ribosomal RNA 8fzj x 74 3.0 RF00005 39030416 0030533 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<.<......>.>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((.(...[..).)).((((.........)))).....((.((..]....)).))))))))).... Cryo-EM structure of an E. coli rotated ribosome bound with RF3-GDPCP and p/E-tRNAPhe (Composite state II-C); p/E phenylalanyl-tRNA 8fzj A 2899 3.0 RF02541 39030416 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcgcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<........>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<.....<.........>.....>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<..>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<....<<..>>.....>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<<.<<....>>..>>>>>>..>....>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<.<..<<<<...........<<<<....<<......<<<<<<<<....>>>>>>>>...>>..............>>>>..>>>>..>.>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......((((((((((.((.(((...(((((......)))))[[(...).(((.....]])))...)))...)).))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((........)))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((..(((.....)))...))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.((.....................)).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((((()))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((((((...(((((.(.........(...(...((........(.((((....)))).).....)).............)...)).)))).)..))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Cryo-EM structure of an E. coli rotated ribosome bound with RF3-GDPCP and p/E-tRNAPhe (Composite state II-C); 23S Ribosomal RNA 8fzj B 120 3.0 RF00001 URS00005C6868_562 39030416 0003735 0005840 562 ugccuggcggcaguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Cryo-EM structure of an E. coli rotated ribosome bound with RF3-GDPCP and p/E-tRNAPhe (Composite state II-C); 5S Ribosomal RNA 8fzt A 38 3.03 URS000268140E_1314 1314 uaccagcaaaacacuccgauguuuuagagcuaugcugu ...................................... ...................................... SpCas9 with dual-guide RNA and target DNA; CrE2 8fzt B 69 3.03 RF02348 URS0002681416_1314 1314 aacagcauagcaaguuaaaauaaggcuaguccguuaucaacuugaaaaaguggcaccgagucggugcuu .......................<<.....>>.......<<<<....>>>>.<<<<<<...>>>>>>.. .......................(((..).)).......((((....)))).((((((...)))))).. SpCas9 with dual-guide RNA and target DNA; tracrRNA 8g29 1A 2871 2.55 RF02541 URS00001698E8_300852 38238495 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<....<<<<........>>>..>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..<<<.......>>>...>>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<.......<<<<.<......>.>>>>....>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<...>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((..(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((.(....(..........)....)..)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((..((.........))...))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(......[..(((((..(((.......(((((((....)))))))....)))..........].)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..(((...)))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the A2503-C2,C8-dimethylated Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.55A resolution; 23S Ribosomal RNA 8g29 1B 120 2.55 RF00001 URS000080DEE8_300852 38238495 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> (((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).))))))))))) Crystal structure of the A2503-C2,C8-dimethylated Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.55A resolution; 5S Ribosomal RNA 8g29 1a 1500 2.55 RF00177,RF01959,RF02542,RF01960 URS000080DFED_300852 38238495 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<......>>....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((..)))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((..((((....))))..))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((((((....)))))))....(((....)))....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the A2503-C2,C8-dimethylated Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.55A resolution; 16S Ribosomal RNA 8g29 1v 13 2.55 38238495 10665 aaaaauguucuaa ............. ............. Crystal structure of the A2503-C2,C8-dimethylated Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.55A resolution; MF-mRNA 8g29 1w 74 2.55 RF00005 URS00005AA258_562 38238495 0030533 0006412 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcaccn <<<<<<<..<<<<......>>>><<<<<<<.....>>>>>>.>...<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[..)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of the A2503-C2,C8-dimethylated Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.55A resolution; A-site Aminoacylated Phe-tRNAphe 8g29 1x 77 2.55 RF00005 URS000041AF00_562 38238495 0030533 0006412 562 cgcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaaccn .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the A2503-C2,C8-dimethylated Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.55A resolution; P-site Aminoacylated fMet-tRNAmet 8g29 1y 74 2.55 RF00005 URS00005AA258_562 38238495 0030533 0006412 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[..)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of the A2503-C2,C8-dimethylated Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.55A resolution; E-site Deacylated tRNAphe 8g29 2A 2800 2.55 RF02541 URS00001698E8_300852 38238495 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>..<....<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<....<<............>.>....>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<..>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>>.<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....(..)....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((....(((..........)).)....)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((((((()))))))))).))..........]]].)....))))))))))...)))))))(((((((..)))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(......[..(((((...(.......((((((((....))))))))....)...........].)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....))))))).(((.))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the A2503-C2,C8-dimethylated Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.55A resolution; 23S Ribosomal RNA 8g29 2B 120 2.55 RF00001 URS000080DEE8_300852 38238495 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the A2503-C2,C8-dimethylated Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.55A resolution; 5S Ribosomal RNA 8g29 2a 1503 2.55 RF00177,RF01959,RF02542,RF01960 URS000080DFED_300852 38238495 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggau .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<......>>....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((((((....))))))).(..(.(....).)..).)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.(.((....)).)).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}... Crystal structure of the A2503-C2,C8-dimethylated Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.55A resolution; 16S Ribosomal RNA 8g29 2v 13 2.55 38238495 10665 aaaaauguucuaa ............. ............. Crystal structure of the A2503-C2,C8-dimethylated Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.55A resolution; MF-mRNA 8g29 2w 72 2.55 RF00005 URS00005AA258_562 38238495 0030533 0006412 562 cccgganagcucagggagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcaccn <<<<<<..<<<<.....>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((...[.)))).((((.........)))).....(((((..]....)))))))))))..... Crystal structure of the A2503-C2,C8-dimethylated Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.55A resolution; A-site Aminoacylated Phe-tRNAphe 8g29 2x 77 2.55 RF00005 URS000041AF00_562 38238495 0030533 0006412 562 cgcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaaccn .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the A2503-C2,C8-dimethylated Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.55A resolution; P-site Aminoacylated fMet-tRNAmet 8g29 2y 73 2.55 RF00005 URS00005AA258_562 38238495 0030533 0006412 562 gcccgganagcucagggagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<.....>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[.)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of the A2503-C2,C8-dimethylated Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.55A resolution; E-site Deacylated tRNAphe 8g2a 1A 2871 2.45 RF02541 URS00001698E8_300852 38238495 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<....<<<<........>>>..>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..<<<.....(.>>>...>>>.........<<......>>.).>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<.......<<<<<<<....>>>>>>>....>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<...>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((..(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...((.().))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...((((((((....(((..........)..))...))))))))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((..((.........))...))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((.((((((((.(......[..(((((..(((.......(((((((....)))))))....)))..........].)))))).)))))))).)))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..(((...)))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the A2503-C2,C8-dimethylated Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Phe-tRNAphe, peptidyl P-site fMTHSMRC-tRNAmet, and deacylated E-site tRNAphe at 2.45A resolution; 23S Ribosomal RNA 8g2a 1B 120 2.45 RF00001 URS000080DEE8_300852 38238495 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> (((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).))))))))))) Crystal structure of the A2503-C2,C8-dimethylated Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Phe-tRNAphe, peptidyl P-site fMTHSMRC-tRNAmet, and deacylated E-site tRNAphe at 2.45A resolution; 5S Ribosomal RNA 8g2a 1a 1500 2.45 RF00177,RF01959,RF02542,RF01960 URS000080DFED_300852 38238495 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<......>>....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((..)))))))).)))))......(((......((((((((..((...(((((((.(((((....(((((......))))).....)))))....((((..((((....))))..))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((.(((....))).)))....(((....)))....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the A2503-C2,C8-dimethylated Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Phe-tRNAphe, peptidyl P-site fMTHSMRC-tRNAmet, and deacylated E-site tRNAphe at 2.45A resolution; 16S Ribosomal RNA 8g2a 1v 13 2.45 38238495 10665 aaaaauguucuaa ............. ............. Crystal structure of the A2503-C2,C8-dimethylated Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Phe-tRNAphe, peptidyl P-site fMTHSMRC-tRNAmet, and deacylated E-site tRNAphe at 2.45A resolution; MF-mRNA 8g2a 1w 74 2.45 RF00005 URS00005AA258_562 38238495 0030533 0006412 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcaccn <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[..)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of the A2503-C2,C8-dimethylated Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Phe-tRNAphe, peptidyl P-site fMTHSMRC-tRNAmet, and deacylated E-site tRNAphe at 2.45A resolution; A-site Aminoacylated Phe-tRNAphe 8g2a 1x 77 2.45 RF00005 URS000041AF00_562 38238495 0030533 0006412 562 cgcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaaccn .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the A2503-C2,C8-dimethylated Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Phe-tRNAphe, peptidyl P-site fMTHSMRC-tRNAmet, and deacylated E-site tRNAphe at 2.45A resolution; P-site Peptidyl-tRNA fMTHSMRC-tRNAmet RNA-part 8g2a 1y 74 2.45 RF00005 URS00005AA258_562 38238495 0030533 0006412 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[..)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of the A2503-C2,C8-dimethylated Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Phe-tRNAphe, peptidyl P-site fMTHSMRC-tRNAmet, and deacylated E-site tRNAphe at 2.45A resolution; E-site Deacylated tRNAphe 8g2a 2A 2800 2.45 RF02541 URS00001698E8_300852 38238495 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<....<<............>.>....>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<..>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (........((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....(..)....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((.(..(...............).)..)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((((((()))))))))).))..........]]].)....))))))))))...)))))))(((((((())))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(......[..(((((..(((......((((((((....))))))))...)))..........].)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))..((.))......(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))......) Crystal structure of the A2503-C2,C8-dimethylated Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Phe-tRNAphe, peptidyl P-site fMTHSMRC-tRNAmet, and deacylated E-site tRNAphe at 2.45A resolution; 23S Ribosomal RNA 8g2a 2B 120 2.45 RF00001 URS000080DEE8_300852 38238495 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the A2503-C2,C8-dimethylated Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Phe-tRNAphe, peptidyl P-site fMTHSMRC-tRNAmet, and deacylated E-site tRNAphe at 2.45A resolution; 5S Ribosomal RNA 8g2a 2a 1503 2.45 RF00177,RF01959,RF02542,RF01960 URS000080DFED_300852 38238495 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggau .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<......>>....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((((((....)))))))....(.(....).)....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.(.((....)).)).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}... Crystal structure of the A2503-C2,C8-dimethylated Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Phe-tRNAphe, peptidyl P-site fMTHSMRC-tRNAmet, and deacylated E-site tRNAphe at 2.45A resolution; 16S Ribosomal RNA 8g2a 2v 13 2.45 38238495 10665 aaaaauguucuaa ............. ............. Crystal structure of the A2503-C2,C8-dimethylated Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Phe-tRNAphe, peptidyl P-site fMTHSMRC-tRNAmet, and deacylated E-site tRNAphe at 2.45A resolution; MF-mRNA 8g2a 2w 72 2.45 RF00005 URS00005AA258_562 38238495 0030533 0006412 562 cccgganagcucagggagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcaccn <<<<<<..<<<<.....>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((...[.)))).((((.........)))).....(((((..]....)))))))))))..... Crystal structure of the A2503-C2,C8-dimethylated Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Phe-tRNAphe, peptidyl P-site fMTHSMRC-tRNAmet, and deacylated E-site tRNAphe at 2.45A resolution; A-site Aminoacylated Phe-tRNAphe 8g2a 2x 77 2.45 RF00005 URS000041AF00_562 38238495 0030533 0006412 562 cgcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaaccn .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the A2503-C2,C8-dimethylated Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Phe-tRNAphe, peptidyl P-site fMTHSMRC-tRNAmet, and deacylated E-site tRNAphe at 2.45A resolution; P-site Peptidyl-tRNA fMTHSMRC-tRNAmet RNA-part 8g2a 2y 73 2.45 RF00005 URS00005AA258_562 38238495 0030533 0006412 562 gcccgganagcucagggagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<.....>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[.)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of the A2503-C2,C8-dimethylated Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Phe-tRNAphe, peptidyl P-site fMTHSMRC-tRNAmet, and deacylated E-site tRNAphe at 2.45A resolution; E-site Deacylated tRNAphe 8g2b 1A 2871 2.55 RF02541 URS00001698E8_300852 38238495 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<.....<<..........>>......>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..<<......(..>>...>>>.........<<......>>.).>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<.......<<<<<<<....>>>>>>>....>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<...>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((..(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((..)))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((.(..(((..........)..)))..)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((..((.........))...))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(......[..(((((..(((......((((((((....))))))))...)))..........].)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..((.....))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the A2503-C2,C8-dimethylated Thermus thermophilus 70S ribosome in complex with iboxamycin, mRNA, deacylated A- and E-site tRNAphe, and aminoacylated P-site fMet-tRNAmet at 2.55A resolution; 23S Ribosomal RNA 8g2b 1B 120 2.55 RF00001 URS000080DEE8_300852 38238495 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> (((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).))))))))))) Crystal structure of the A2503-C2,C8-dimethylated Thermus thermophilus 70S ribosome in complex with iboxamycin, mRNA, deacylated A- and E-site tRNAphe, and aminoacylated P-site fMet-tRNAmet at 2.55A resolution; 5S Ribosomal RNA 8g2b 1a 1500 2.55 RF00177,RF01959,RF02542,RF01960 URS000080DFED_300852 38238495 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<......>>....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((((((....))))))).)))))......(((......((((((((..((...(((((((.(((((....(.((((....)))).).....)))))....((((..((((....))))..))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((...(((((((....)))))))....(((....)))....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the A2503-C2,C8-dimethylated Thermus thermophilus 70S ribosome in complex with iboxamycin, mRNA, deacylated A- and E-site tRNAphe, and aminoacylated P-site fMet-tRNAmet at 2.55A resolution; 16S Ribosomal RNA 8g2b 1v 13 2.55 38238495 10665 aaaaauguucuaa ............. ............. Crystal structure of the A2503-C2,C8-dimethylated Thermus thermophilus 70S ribosome in complex with iboxamycin, mRNA, deacylated A- and E-site tRNAphe, and aminoacylated P-site fMet-tRNAmet at 2.55A resolution; MF-mRNA 8g2b 1w 73 2.55 RF00005 URS00005AA258_562 38238495 0030533 0006412 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacc <<<<<<<..<<<<......>>>><<<<<<<.....>>>>>>.>...<<<<<.......>>>>>>>>>>>>... (.(((((..((((...[..)))).((((.........)))).....(((((..]....)))))))))).)... Crystal structure of the A2503-C2,C8-dimethylated Thermus thermophilus 70S ribosome in complex with iboxamycin, mRNA, deacylated A- and E-site tRNAphe, and aminoacylated P-site fMet-tRNAmet at 2.55A resolution; A-site and E-site Deacylated tRNAphe 8g2b 1x 76 2.55 RF00005 URS000041AF00_562 38238495 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaaccn <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the A2503-C2,C8-dimethylated Thermus thermophilus 70S ribosome in complex with iboxamycin, mRNA, deacylated A- and E-site tRNAphe, and aminoacylated P-site fMet-tRNAmet at 2.55A resolution; P-site Aminoacylated fMet-tRNAmet 8g2b 1y 74 2.55 RF00005 URS00005AA258_562 38238495 0030533 0006412 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[..)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of the A2503-C2,C8-dimethylated Thermus thermophilus 70S ribosome in complex with iboxamycin, mRNA, deacylated A- and E-site tRNAphe, and aminoacylated P-site fMet-tRNAmet at 2.55A resolution; A-site and E-site Deacylated tRNAphe 8g2b 2A 2800 2.55 RF02541 URS00001698E8_300852 38238495 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<..........>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<..>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...((((((((.....))))))))....{.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).))))....(((((((((.[.....)))))))))....}.(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((()))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((.(..((............).).)..)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((((((()))))))))).))..........]]].)....))))))))))...)))))))(((((((..)))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........(((((..(((......((((((((....))))))))...)))............)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....))))))).(((.))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the A2503-C2,C8-dimethylated Thermus thermophilus 70S ribosome in complex with iboxamycin, mRNA, deacylated A- and E-site tRNAphe, and aminoacylated P-site fMet-tRNAmet at 2.55A resolution; 23S Ribosomal RNA 8g2b 2B 120 2.55 RF00001 URS000080DEE8_300852 38238495 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>>. ..(((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).))))))))).. Crystal structure of the A2503-C2,C8-dimethylated Thermus thermophilus 70S ribosome in complex with iboxamycin, mRNA, deacylated A- and E-site tRNAphe, and aminoacylated P-site fMet-tRNAmet at 2.55A resolution; 5S Ribosomal RNA 8g2b 2a 1503 2.55 RF00177,RF01959,RF02542,RF01960 URS000080DFED_300852 38238495 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggau .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<......>>....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<..<.<<<<<<<........>>>>>>>>...>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((((((....))))))).(..(((....)))..).)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..(.((....)).)..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}... Crystal structure of the A2503-C2,C8-dimethylated Thermus thermophilus 70S ribosome in complex with iboxamycin, mRNA, deacylated A- and E-site tRNAphe, and aminoacylated P-site fMet-tRNAmet at 2.55A resolution; 16S Ribosomal RNA 8g2b 2v 13 2.55 38238495 10665 aaaaauguucuaa ............. ............. Crystal structure of the A2503-C2,C8-dimethylated Thermus thermophilus 70S ribosome in complex with iboxamycin, mRNA, deacylated A- and E-site tRNAphe, and aminoacylated P-site fMet-tRNAmet at 2.55A resolution; MF-mRNA 8g2b 2w 70 2.55 RF00005 URS00005AA258_562 38238495 0030533 0006412 562 cccgganagcucagggagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcac <<<<<<..<<<<.....>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>... ((((((..((((...[.)))).((((.........)))).....(((((..]....)))))))))))... Crystal structure of the A2503-C2,C8-dimethylated Thermus thermophilus 70S ribosome in complex with iboxamycin, mRNA, deacylated A- and E-site tRNAphe, and aminoacylated P-site fMet-tRNAmet at 2.55A resolution; A-site and E-site Deacylated tRNAphe 8g2b 2x 76 2.55 RF00005 URS000041AF00_562 38238495 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaaccn <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the A2503-C2,C8-dimethylated Thermus thermophilus 70S ribosome in complex with iboxamycin, mRNA, deacylated A- and E-site tRNAphe, and aminoacylated P-site fMet-tRNAmet at 2.55A resolution; P-site Aminoacylated fMet-tRNAmet 8g2b 2y 73 2.55 RF00005 URS00005AA258_562 38238495 0030533 0006412 562 gcccgganagcucagggagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<.....>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....)))).((((.........)))).....(((((.......)))))))))))).... Crystal structure of the A2503-C2,C8-dimethylated Thermus thermophilus 70S ribosome in complex with iboxamycin, mRNA, deacylated A- and E-site tRNAphe, and aminoacylated P-site fMet-tRNAmet at 2.55A resolution; A-site and E-site Deacylated tRNAphe 8g2c 1A 2871 2.65 RF02541 URS00001698E8_300852 38238495 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<....<<<<........>>>..>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..<<<.....(.>>>...>>>.........<<......>>.).>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<.......<<<<<<<....>>>>>>>....>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<...>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((..(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((.(..(((..........)..)))..)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((..((.........))...))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(......[..(((((..(((.......(((((((....)))))))....)))..........].)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..(((...)))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the A2503-C2,C8-dimethylated Thermus thermophilus 70S ribosome in complex with tylosin, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.65A resolution; 23S Ribosomal RNA 8g2c 1B 120 2.65 RF00001 URS000080DEE8_300852 38238495 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> (((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).))))))))))) Crystal structure of the A2503-C2,C8-dimethylated Thermus thermophilus 70S ribosome in complex with tylosin, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.65A resolution; 5S Ribosomal RNA 8g2c 1a 1500 2.65 RF00177,RF01959,RF02542,RF01960 URS000080DFED_300852 38238495 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<......>>....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((..)))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((..((((....))))..))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((((((....)))))))....(((....)))....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the A2503-C2,C8-dimethylated Thermus thermophilus 70S ribosome in complex with tylosin, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.65A resolution; 16S Ribosomal RNA 8g2c 1v 13 2.65 38238495 10665 aaaaauguucuaa ............. ............. Crystal structure of the A2503-C2,C8-dimethylated Thermus thermophilus 70S ribosome in complex with tylosin, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.65A resolution; MF-mRNA 8g2c 1w 74 2.65 RF00005 URS00005AA258_562 38238495 0030533 0006412 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcaccn <<<<<<<..<<<<......>>>><<<<<<<.....>>>>>>.>...<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[..)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of the A2503-C2,C8-dimethylated Thermus thermophilus 70S ribosome in complex with tylosin, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.65A resolution; A-site Aminoacylated Phe-tRNAphe 8g2c 1x 77 2.65 RF00005 URS000041AF00_562 38238495 0030533 0006412 562 cgcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaaccn .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the A2503-C2,C8-dimethylated Thermus thermophilus 70S ribosome in complex with tylosin, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.65A resolution; P-site Aminoacylated fMet-tRNAmet 8g2c 1y 74 2.65 RF00005 URS00005AA258_562 38238495 0030533 0006412 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[..)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of the A2503-C2,C8-dimethylated Thermus thermophilus 70S ribosome in complex with tylosin, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.65A resolution; E-site Deacylated tRNAphe 8g2c 2A 2800 2.65 RF02541 URS00001698E8_300852 38238495 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<....<<............>.>....>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<..>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....(())....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((....((............).)....)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((((((()))))))))).))..........]]].)....))))))))))...)))))))(((((((())))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(......[..(((((..((.......((((((((....))))))))....))..........].)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....))))))).(((.))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the A2503-C2,C8-dimethylated Thermus thermophilus 70S ribosome in complex with tylosin, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.65A resolution; 23S Ribosomal RNA 8g2c 2B 120 2.65 RF00001 URS000080DEE8_300852 38238495 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>>. ..(((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).))))))))).. Crystal structure of the A2503-C2,C8-dimethylated Thermus thermophilus 70S ribosome in complex with tylosin, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.65A resolution; 5S Ribosomal RNA 8g2c 2a 1503 2.65 RF00177,RF01959,RF02542,RF01960 URS000080DFED_300852 38238495 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggau .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<......>>....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...((((((......))))))....(.(....).)....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.(.((....)).)).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}... Crystal structure of the A2503-C2,C8-dimethylated Thermus thermophilus 70S ribosome in complex with tylosin, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.65A resolution; 16S Ribosomal RNA 8g2c 2v 13 2.65 38238495 10665 aaaaauguucuaa ............. ............. Crystal structure of the A2503-C2,C8-dimethylated Thermus thermophilus 70S ribosome in complex with tylosin, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.65A resolution; MF-mRNA 8g2c 2w 72 2.65 RF00005 URS00005AA258_562 38238495 0030533 0006412 562 cccgganagcucagggagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcaccn <<<<<<..<<<<.....>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((...[.)))).((((.........)))).....(((((..]....)))))))))))..... Crystal structure of the A2503-C2,C8-dimethylated Thermus thermophilus 70S ribosome in complex with tylosin, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.65A resolution; A-site Aminoacylated Phe-tRNAphe 8g2c 2x 77 2.65 RF00005 URS000041AF00_562 38238495 0030533 0006412 562 cgcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaaccn .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the A2503-C2,C8-dimethylated Thermus thermophilus 70S ribosome in complex with tylosin, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.65A resolution; P-site Aminoacylated fMet-tRNAmet 8g2c 2y 73 2.65 RF00005 URS00005AA258_562 38238495 0030533 0006412 562 gcccgganagcucagggagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<.....>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[.)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of the A2503-C2,C8-dimethylated Thermus thermophilus 70S ribosome in complex with tylosin, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.65A resolution; E-site Deacylated tRNAphe 8g2d 1A 2871 2.7 RF02541 URS00001698E8_300852 38238495 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<.....<<<........>>>......>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..<<......(..>>...>>>.........<<......>>.).>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<.<<....>>.>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<...>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((...((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....((((((((..[......))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((.(..(((.(......).)..)))..)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((..((.........))...))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((.((((((((((((.(......[..(((((..(((......((((((((....))))))))...)))..........].)))))).)))))))))))).)))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..((.....))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with tylosin, mRNA, deacylated A- and E-site tRNAphe, and deacylated P-site tRNAmet at 2.70A resolution; 23S Ribosomal RNA 8g2d 1B 120 2.7 RF00001 URS000080DEE8_300852 38238495 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with tylosin, mRNA, deacylated A- and E-site tRNAphe, and deacylated P-site tRNAmet at 2.70A resolution; 5S Ribosomal RNA 8g2d 1a 1500 2.7 RF00177,RF01959,RF02542,RF01960 URS000080DFED_300852 38238495 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>.<..<<......>>.>..>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((((((....))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((..((((....))))..))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((...(((.(((....))).)))....(((....)))....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with tylosin, mRNA, deacylated A- and E-site tRNAphe, and deacylated P-site tRNAmet at 2.70A resolution; 16S Ribosomal RNA 8g2d 1v 13 2.7 38238495 10665 aaaaauguucuaa ............. ............. Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with tylosin, mRNA, deacylated A- and E-site tRNAphe, and deacylated P-site tRNAmet at 2.70A resolution; MF-mRNA 8g2d 1w 74 2.7 RF00005 URS00005AA258_562 38238495 0030533 0006412 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[..)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with tylosin, mRNA, deacylated A- and E-site tRNAphe, and deacylated P-site tRNAmet at 2.70A resolution; A-site and E-site Deacylated tRNAphe 8g2d 1x 76 2.7 RF00005 URS000041AF00_562 38238495 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with tylosin, mRNA, deacylated A- and E-site tRNAphe, and deacylated P-site tRNAmet at 2.70A resolution; P-site Deacylated tRNAmet 8g2d 1y 74 2.7 RF00005 URS00005AA258_562 38238495 0030533 0006412 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[..)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with tylosin, mRNA, deacylated A- and E-site tRNAphe, and deacylated P-site tRNAmet at 2.70A resolution; A-site and E-site Deacylated tRNAphe 8g2d 2A 2800 2.7 RF02541 URS00001698E8_300852 38238495 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<........>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<..>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<...<<......<<<<<<<<....>>>>>>>>...>>.............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....(())....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((((((......((..........)).......)))))))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((.().)))))))).))..........]]].)....))))))))))...)))))))(((((((..)))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(......[..(((((...((......((((((((....))))))))...))...........].)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....))))))).((...)).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with tylosin, mRNA, deacylated A- and E-site tRNAphe, and deacylated P-site tRNAmet at 2.70A resolution; 23S Ribosomal RNA 8g2d 2B 120 2.7 RF00001 URS000080DEE8_300852 38238495 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>>. ..(((((((((....((((((.(....(((((((...(.....)...))))..)))...).)))).))(((.......((((((((....)))))))).......))).))))))))).. Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with tylosin, mRNA, deacylated A- and E-site tRNAphe, and deacylated P-site tRNAmet at 2.70A resolution; 5S Ribosomal RNA 8g2d 2a 1503 2.7 RF00177,RF01959,RF02542,RF01960 URS000080DFED_300852 38238495 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggau .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>....<<......>>...>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((...(((((((....)))))))....(.(....).)....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with tylosin, mRNA, deacylated A- and E-site tRNAphe, and deacylated P-site tRNAmet at 2.70A resolution; 16S Ribosomal RNA 8g2d 2v 13 2.7 38238495 10665 aaaaauguucuaa ............. ............. Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with tylosin, mRNA, deacylated A- and E-site tRNAphe, and deacylated P-site tRNAmet at 2.70A resolution; MF-mRNA 8g2d 2w 72 2.7 RF00005 URS00005AA258_562 38238495 0030533 0006412 562 cccgganagcucagggagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<..<<<<.....>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((...[.)))).((((.........))))......((((..]....)))).))))))..... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with tylosin, mRNA, deacylated A- and E-site tRNAphe, and deacylated P-site tRNAmet at 2.70A resolution; A-site and E-site Deacylated tRNAphe 8g2d 2x 76 2.7 RF00005 URS000041AF00_562 38238495 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with tylosin, mRNA, deacylated A- and E-site tRNAphe, and deacylated P-site tRNAmet at 2.70A resolution; P-site Deacylated tRNAmet 8g2d 2y 73 2.7 RF00005 URS00005AA258_562 38238495 0030533 0006412 562 gcccgganagcucagggagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<.....>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[.)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with tylosin, mRNA, deacylated A- and E-site tRNAphe, and deacylated P-site tRNAmet at 2.70A resolution; A-site and E-site Deacylated tRNAphe 8g2u A 117 3.0 RF00001 URS000080DF7E_562 38244547 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggc <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>> (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))) Time-resolved cryo-EM study of the 70S recycling by the HflX:control-apo-70S at 900ms; 5S rRNA 8g2u B 2903 3.0 RF02541 URS000080E25C_562 38244547 0003735 0005840 562 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<<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<..<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>..>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<...<.......>....>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<.........<<<<.<<...<<<.........>>>...>>........<<<......>>>..>>>>.....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<....<<..>>.....>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<<.<<....>>..>>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<.<<<<....<.............<<.................<<........>>........................>>....>....>>>>.>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<<...>>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. 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Time-resolved cryo-EM study of the 70S recycling by the HflX:control-apo-70S at 900ms; 23S rRNA 8g2u v 1539 3.0 RF01959,RF00177,RF02542,RF01960 URS000080DDC0_562 38244547 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<<....>>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<..<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>..>>>.>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<........<<<<<..<<<<<<<....>>>>>>>.............>>>>>....<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<....<<<.....>>>....>.>>>>>>>.....<<<<<.....>>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((.(((..(....)..)))..)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....(((.((((.......)))).))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.((((((..((.(((((((......((((((.....))))))....)))))))...)).))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(.(((((...((((((....))))))..............)))))..)).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((.(....(..((.......))).....).)))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((.(((........))).)))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..(..(..(((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).)))...)..)...)..)..(((((((((....)))))))))}........... Time-resolved cryo-EM study of the 70S recycling by the HflX:control-apo-70S at 900ms; 16S rRNA 8g31 A 117 3.2 RF00001 URS000080DF7E_562 38244547 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggc <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<...<...<<<<<<<<...>>>>>>>>.....>.>>...>>>>>>>>> (((((((((.....((((((.(....(((((((...(.....)...))))..)))...).)))).)).((.......((.(((((...))))).)).......))...))))))))) Time-resolved cryo-EM study of the 70S recycling by the HflX:2nd Intermediate; 5S 8g31 B 2903 3.2 RF02541 URS000080E25C_562 38244547 0003735 0005840 562 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Time-resolved cryo-EM study of the 70S recycling by the HflX:2nd Intermediate; 23S 8g31 v 1539 3.2 RF01959,RF00177,RF02542,RF01960 URS000080DDC0_562 38244547 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<....<<<....>>>.....>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<......>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.<...>.>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<..<<<<<.......<<<<<......<<........>>..........<..<.<.......<<<<<<<..<<<<<<<....>>>>>>>.............>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>.>...>...>>.>>>..........<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>...............<<.........>.>..............>>>>>.....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<....<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>.....>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((.(...((....).)...).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((........))))......)).).....(((....)))....(((.((..((....)))).))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).(((......)))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((.......(((..(.....((........))...........(.(.(...(...(((((((..(((((((....))))))).............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....).)..)....)..)))......(...(((((((.....(((..((...(((....)))...))....))).....)))))))................(.........).............)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((....(...(((..(((((((.((((....((((((.((((..((....)).))))))))))...)))).)))))))..)))...).....))...)..)..(((((((((....)))))))))}........... Time-resolved cryo-EM study of the 70S recycling by the HflX:2nd Intermediate; 16S 8g34 A 117 3.2 RF00001 URS000080DF7E_562 38244547 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggc <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>> (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))) Time-resolved cryo-EM study of the 70S recycling by the HflX:1st intermediate; 5S 8g34 B 2903 3.2 RF02541 URS000080E25C_562 38244547 0003735 0005840 562 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Time-resolved cryo-EM study of the 70S recycling by the HflX:1st intermediate; 23S 8g34 v 1539 3.2 RF01959,RF00177,RF02542,RF01960 URS00029156B1_562 38244547 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucccaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<....<<<....>>>.....>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<......>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<.......<<<<<......<<........>>..........<<<<.<.......<<<<<<<..<<<<<<<....>>>>>>>.............>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>.>.>>>...>>.>>>..........<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>................<.........>................>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<..<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>..>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((.(...((....).)...).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((........))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).(((......)))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..(....(((((......((........))...........(.(.(...(...(((((((..(((((((....))))))).............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....).)..)....)).)))....).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(.........(.........)..........)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((..((.....((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..)).....)..).))...)..)..(((((((((....)))))))))}........... Time-resolved cryo-EM study of the 70S recycling by the HflX:1st intermediate; 16S 8g38 A 117 3.2 RF00001 URS000080DF7E_562 38244547 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggc <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>> (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))) Time-resolved cryo-EM study of the 70S recycling by the HflX:3rd Intermediate; 5S 8g38 B 2903 3.2 RF02541 URS000080E25C_562 38244547 0003735 0005840 562 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<<..<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<..<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>..>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<<........................>.>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<................>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<..........<<<.<<...<<...........>>...>>........<<<......>>>..>>>......>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<......>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<<.<<....>>..>>>>>>........>>>>>>>>..>>>>><<...............>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<...<<.....................<...................................................>............>>...>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>.(<<...<<<<<<<....<<<<<.......>>>>>......<<)..(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<..<<<<<<<<<<<<))).>>>>>>..>>>>>>..>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<<...>>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>..>>. 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Time-resolved cryo-EM study of the 70S recycling by the HflX:3rd Intermediate; 23S 8g38 v 1539 3.2 RF01959,RF00177,RF02542,RF01960 URS000080DDC0_562 38244547 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<....<<<....>>>.....>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<......>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.<...>.>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<.......<<<<<......<<........>>........<.<..<.<.......<<<<<<<..<<<<<<<....>>>>>>>.............>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>.>...>>..>>.>>>..........<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>...............<<.........>.>..............>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<........<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.........>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((.(...((....).)...).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((........))))......)).).....(((....)))....(((.((..((....)))).))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).(((......)))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((.......(((..(.....((........)).............(.(...(...(((((((..(((((((....))))))).............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....).).......)..)))......(...(((((((.....(((..((...(((....)))...))....))).....)))))))........................................)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((........(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).........))...)..)..(((((((((....)))))))))}........... Time-resolved cryo-EM study of the 70S recycling by the HflX:3rd Intermediate; 16S 8g4i 2 1441 3.24 RF01960,RF02542,RF01959,RF00177 URS00029156C2_941442 38242118 0003735 0005840 941442 cauccggucgauccugccggagcgcgacgcucuccccaaggacgaagccaugcaugcccgcucaccggacgcggcggacggcucaggacaacgguugcaccccccgcggcgguccuagccggacaccgcuggcaacccggcgccaagacgugcgcgcaagggcgggcgcccgggcgagcagcgugacgcagcgacggcccgcccgggcuuccggggcaucacccggucggcgcggucgcggcgcgccgagggcccgacgccuggcggagaaucaggguucgacuccggagagcgggccugcgagacggcccgcacauccaaggacggcagcaggcgcggaacuugcccaaugcgcggcgcgcgaggcagcgacggggagcgcgcgagcgaggcgggcccacagcccccgccgcggagccgagggcaagcuggugccagcagccgcgguaauuccagcucggcgagcgucgcgcggcgcugcugcaguugaaacgcccguaguuggccccccgccgccacgaggaaacgggagcgcuccaggcaggcccguuggacccgccgcgugggaccgcgcagcgggcgcggcgcgccgcggcagccccgaggagagcgggcgggggcaccgguaccggccggggacgggugaaacaggaugaucccgccgagaccgccggccgcgcaggcgccugccaagaccgccucugucaaucaagggcgaaggccgggggcuagaaggcgaucagacaccaccguauucccggccguaaacggugccgccccgcggccggcgcgcgcgucccgccggccgcccagggaaaccgggaggcuccgggcucuggggggaguauggccgcaaggcugaaacuugaaggcauugacggagggguaccaccagacguggagucugcggcucaaucugacccaacgcgcgcaccucaccaggcccggacgcgcggaggaccgacagccgggcgcgcuuucgcgaucgcgcgggcgguggugcauggccgcucccagcccguggcgcgagccgucugcuccauugcgacaacgagcgagaccccggccgcgggcgccgcgggacggcccgcgcgagcgggaggacggcggggcgauagcaggucugugaugcccucagacgcccugggccgcacgcgcgcuacacuggcggggccagccggcgcccgcgaggacgcgcggagcccccgccguggccgggaccgcgggcuggaacgcccccgcgcaccaggaaugucuuguaggcgcccgcccccaccgcgcgccggacgcgucccugccccuuguacacaccgcccgucgcuccuaccgacugggcgcggcggcgagcgccccggacgcgcgaagggccgcgagcccccgcgccuggaggaaggagaagucguaacaagguauccguaggugaaccugcggauggaucccu ...<<<<<.{..(((>>>>>.<<<<<<<<<..<<<<<..<......<<<.<<<..<<<.<<.........>>>>>......<<........<<<..<<..<<...<<<<..........<<.....<<<<<<....>>>>>>......>>......<....<<<...(((..<.....>..>>>...>..........>>>>..>>>>..>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>...<<<<<<<<....>>>>...>>>>.>>.<<<<<<..........>>>>>>.<.<<<..>>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>>>>............<<<<<<.........>>>>>>.....<<<<<((....<<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<[[.....<<<<...<<<.......<<<.<<<<<<.<.....<<..<<.......>>............>>..>..>>>>>..>.>>>..<<.<<<..)))..>>>...>>..........<<<<<<<.....<<<<..<<..<<<<<.<<<..<.<......>.>.....>>>.>>>>.>.>>.......<<....>>...>>>>....>>>>.>>>...>>>...>>>>...<<<<<<<<...<...<<.<.<.....>.>.>>...>>>>>>>>>.........<<<.<<..<<<<<<<<<<.<.....>.>>>>>>>>>>...<<..]]>>....>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..)))..}<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>.........<<<<<.<....<<<<<<......<<<.<<<.......>>>.>>>....>>>>>>...<<.<<<..<<.<<<<<<....<<.<<<<<<....>>>....<<......>>....>>>.>>....<<<<..<<<<<<...>>>>>>.....<<<<<....>>>>>........>>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<<.......<<<.<<....>>.>>>.......>>>>>>>...........<<.<<<<......>>>>.>>..........>>>>>>....<<<<<.<<.......>>.>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<<.<<....<<<<<<<<.<<<..<<<.<<<...........>>>.>>>..>>>.>>>>>>>>...>>.>>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>........ ...((((..[..[[..)))).(((((((((..(((((..((.....(((.(((..(((.((.........)))))......(((.......(((..((..((...((((..........((.....((((((....))))))......))...(.((....(((...[[[..(.....)..)))...))..)......))))..))))..))).(((....(((..((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((((((..........)))))).(.((....)).)...)))))).).....(.(((...(((((...)))).))))).)...)))))...(..).....((((((.........)))))).....((((([[....(((((.....((..]])).......))))))))))..)))))))))...{......((({{...(.((((...(((.......(((.((((((.(.....((..((.......))............))..)..)))))..).)))..((.(((..]]]..)))...)).........((((((((.(...((((..((...((((.((...(..........)......)).))))...)).......((....))...))))..).)))).)))..))))...))))....((((((....(...((.(.........).))...).))))))......<...(((.((..((((((((((.((..).).))))))))))...((..}}))....))...}.))))))).(((......((((....))))....)))...]]..](((((.(((((((..((..(((((..(((.((((((......((........)).........(((((.(....((((((....(.(((.(((.......))).)))...)))))))...((.(((.....((((((....((.((((((....)))..(.((......)))...))).))....((((..((((((...))))))..(..(((((....))))).....)..))))....))).))).......))))).....).)))))...)).)))).))).(...(((((((.......(((.((....)).))).......)))))))......(....((.((((......)))).))....)..)..))))).....(((((.((.......)).)))))......))...)))))))))).))..(.(..((.(.(((((.((..(.((((((((.(((..(((.(((...........))).)))..))).)))))))))..)).)))))..).))...)..)..(((((((((....)))))))))>....... 40S ribosomal subunit of the 80S Giardia intestinalis assemblage A ribosome with Emetine bound in V1 conformation; 18S rRNA 8g4i g 74 3.24 RF00005 URS00029156E7_941442 38242118 0030533 0006412 941442 ggguaauuggcgcaguugguuagcgcgcgggucucauaaucccgagcucgugaguucgauccgcacauucccca <<<<.....<<...........>><.<..<......>...>>....<..<.........>..>...>>>>.... (..(.....((...........))(.(.............))....(...(.......)...)...)..).... 40S ribosomal subunit of the 80S Giardia intestinalis assemblage A ribosome with Emetine bound in V1 conformation; tRNA 8g4s 2 1441 3.14 RF01960,RF02542,RF01959,RF00177 URS00029156C2_941442 38242118 0003735 0005840 941442 cauccggucgauccugccggagcgcgacgcucuccccaaggacgaagccaugcaugcccgcucaccggacgcggcggacggcucaggacaacgguugcaccccccgcggcgguccuagccggacaccgcuggcaacccggcgccaagacgugcgcgcaagggcgggcgcccgggcgagcagcgugacgcagcgacggcccgcccgggcuuccggggcaucacccggucggcgcggucgcggcgcgccgagggcccgacgccuggcggagaaucaggguucgacuccggagagcgggccugcgagacggcccgcacauccaaggacggcagcaggcgcggaacuugcccaaugcgcggcgcgcgaggcagcgacggggagcgcgcgagcgaggcgggcccacagcccccgccgcggagccgagggcaagcuggugccagcagccgcgguaauuccagcucggcgagcgucgcgcggcgcugcugcaguugaaacgcccguaguuggccccccgccgccacgaggaaacgggagcgcuccaggcaggcccguuggacccgccgcgugggaccgcgcagcgggcgcggcgcgccgcggcagccccgaggagagcgggcgggggcaccgguaccggccggggacgggugaaacaggaugaucccgccgagaccgccggccgcgcaggcgccugccaagaccgccucugucaaucaagggcgaaggccgggggcuagaaggcgaucagacaccaccguauucccggccguaaacggugccgccccgcggccggcgcgcgcgucccgccggccgcccagggaaaccgggaggcuccgggcucuggggggaguauggccgcaaggcugaaacuugaaggcauugacggagggguaccaccagacguggagucugcggcucaaucugacccaacgcgcgcaccucaccaggcccggacgcgcggaggaccgacagccgggcgcgcuuucgcgaucgcgcgggcgguggugcauggccgcucccagcccguggcgcgagccgucugcuccauugcgacaacgagcgagaccccggccgcgggcgccgcgggacggcccgcgcgagcgggaggacggcggggcgauagcaggucugugaugcccucagacgcccugggccgcacgcgcgcuacacuggcggggccagccggcgcccgcgaggacgcgcggagcccccgccguggccgggaccgcgggcuggaacgcccccgcgcaccaggaaugucuuguaggcgcccgcccccaccgcgcgccggacgcgucccugccccuuguacacaccgcccgucgcuccuaccgacugggcgcggcggcgagcgccccggacgcgcgaagggccgcgagcccccgcgccuggaggaaggagaagucguaacaagguauccguaggugaaccugcggauggaucccu ...<<<<<.{..(((>>>>>.<<<<<<<<<..<<<<<..<......<<<.<<<..<<.<<<.........>>>>>......<<........<<<..<<..<<...<<<<<.........<<.....<<<<<<....>>>>>>......>>.....<<....<<<...(((..<.....>..>>>...>>.......>.>>>>..>>>>..>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>...<<<<<<<<....>>>>...>>>>.>>.<<<<<<..........>>>>>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>>>>............<<<<<<.........>>>>>>.....<<<<<((....<<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<[[.....<<<<...<<<.......<<<.<<<<<<.<.....<<..<<.......>>............>>..>..>>>>>..>.>>>..<<.<<<..)))..>>>...>>..........<<<<<<<.....<<<<..<<..<<<<<.<<<..<.<......>.>.....>>>.>>>>.>.>>.......<<....>>...>>>>....>>>>.>>>...>>>...>>>>...<<<<<<<<...<...<<.<.<.....>.>.>>...>>>>>>>>>.........<<<.<<..<<<<<<<<<<.<.....>.>>>>>>>>>>...<<..]]>>....>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..)))..}<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>.........<<<<<.<....<<<<<<......<<<.<<<.......>>>.>>>....>>>>>>...<<.<<<..<<.<<<<<<....<<.<<<<<<....>>>....<<......>>....>>>.>>....<<<<..<<<<<<...>>>>>>.....<<<<<....>>>>>........>>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<<.......<<<.<<....>>.>>>.......>>>>>>>......<....<<.<<<<......>>>>.>>....>.....>>>>>>....<<<<<.<<.......>>.>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<<.<<....<<<<<<<<.<<<..<<<.<<<...........>>>.>>>..>>>.>>>>>>>>...>>.>>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>........ ...((((..[..[[..)))).(((((((((..(((((..((.....(((.(((..(((.((.........)))))......(((.......(((..((..((...((((..........((.....((((((....))))))......))...(.((....(((...[[[..(.....)..)))...))..)......))))..))))..))).(((....(((..((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((((((..........)))))).(.((....)).)...)))))).).....(.(((...(((((...)))).))))).)...)))))...(..).....((((((.........)))))).....((((([[....(((((.....((..]])).......))))))))))..)))))))))...{......((({{...(.((((...(((.......(((.((((((.(.....((..((.......)).(...)......))..)..)))))..).)))..((.(((..]]]..)))...)).........((((((((.(...((((..((...((((.((...(..........)......)).))))...)).......((....))...))))..).)))).)))..))))...))))....((((((....(...((.(.........).))...).))))))......<...(((.((..((((((((((.((..).).))))))))))...((..}}))....))...}.))))))).(((......((((....))))....)))...]]..](((((.(((((((..((..(((((..(((.((((((......((........)).........(((((.(....((((((....(.(((.(((.......))).)))...)))))))...((.(((...(.((((((....((.((((((....)))..(.((......)))...))).))....((((..((((((...))))))..(..(((((....))))).....)..))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((.......(((.((....)).))).......)))))))......(....((.((((......)))).))....)..)..))))).....(((((.((.......)).)))))......))...)))))))))).))..(.(..((.(.(((((.((..(.((((((((.(((..(((.(((...........))).)))..))).)))))))))..)).)))))..).))...)..)..(((((((((....)))))))))>....... 40S ribosomal subunit of the 80S Giardia intestinalis assemblage A ribosome with Emetine bound in V2 conformation with mRNA and three tRNAs.; 18S rRNA 8g4s g 74 3.14 RF00005 URS00029156E7_941442 38242118 0030533 0006412 941442 ggguaauuggcgcaguugguuagcgcgcgggucucauaaucccgagcucgugaguucgauccgcacauucccca <<<<.....<<...........>><.<............>.>.......<.........>......>>>>.... (..(.....((...........))(................)....(...(.......)...)...)..).... 40S ribosomal subunit of the 80S Giardia intestinalis assemblage A ribosome with Emetine bound in V2 conformation with mRNA and three tRNAs.; E-site tRNA 8g4s h 74 3.14 RF00005 URS00029156CD_941442 38242118 0030533 0006412 941442 gcgggguggagcagcgguagcucgucgggcucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((....[..)))).(((((.......))))).....(.(((..]....))).)))))))..... 40S ribosomal subunit of the 80S Giardia intestinalis assemblage A ribosome with Emetine bound in V2 conformation with mRNA and three tRNAs.; P-site tRNA 8g4s i 75 3.14 RF00005 URS00029156C9_941442 38242118 0030533 0006412 941442 gcccggauagcucagucgguagagcaggggauuuaaaauccccguguccuugguucgauuccgaguccgggcacc <<.<<<<..<<<..........>>>.<<<<<<.....>>>>>>......<<<<.......>>>>.>>>>.>>... .(..((....(............)...((((.......))))........(((.......)).)..))..).... 40S ribosomal subunit of the 80S Giardia intestinalis assemblage A ribosome with Emetine bound in V2 conformation with mRNA and three tRNAs.; A-site tRNA 8g5y S2 1680 2.29 RF01960,RF02542,RF01959,RF00177 URS00026813DB_9606 37020024 0003735 0005840 9606 uaccugguugauccugccaguagcaunugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucnuuaaaucaguuauggunccuunggucgcucgcuccucucccacuuggauaacugugguanuucuagngcuaananaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgccccccguggcggcgacgacccauucgaacgucngcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgaunccggaganggagccugagaaacggcuaccacauncaaggnaggcagcaggcgcgcnaauuacccacucccgacccggggangungugangaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaanuccuuuaacgaggnuccauuggagngcaagucuggugccagcagccgcggnaauuccagcuccaauancguauauuaaaguugcugcaguunaaaagcucguaguungaucuuuuuacuuugaaaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaaungaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagancgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacncaacacgggaaaccucacccggcccggacacggacagganugacagauugauagcucuuucucgauuccguggguggngnugcauggcnguucuuaguugguggagcgauuugucugguuaauuccgauaacgancgagacunuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuncuuanagggacaaguggcguucagccacccgagauugagcaauaacangucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgagnaauucccaguaagugcgggucauaagcuugcguugauunagucccugcccuuuguacacaccgnccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggcggagcgcugagaagacggucgaacungacuaucuagaggaaguaaaagucguancaagguuucnguaggugnnccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<....<<....<<<<<..................<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<<......>>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<<......>>>>>>>>.>>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....<<<<<<<<<.<<<....>>.>.>>>>>.>>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<.....<<<<<<.<.......<<...<.......>.<<<<.......>>>>...>>......>.>>>..>>>........<.<<.<<<<<<<...............>>>>>>>.>>.>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<<....>>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<.......<<........>>..........<<<<<.<....<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<.......>>>>.>>>>.....>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.....>.>>>>>....>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>............<<<<<..........>>>>>...........>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<.<<<<..>>>>...>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))((...(((((......(..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..((....((((....((.............((.....((.(((.....))).))......))......)).((((...(((((......)))))...))))((..(((((...(......)..)))))......)).(.((((..((((...).))).))))).).)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)........(((((((((..((....))...))))).))))....(.((..(...........)..))......)..((((([[....(.(.((.....((..]])).......)).)))))))..)))))...))..[......(.([[...(.(.((...(.(..(.....(..(((.(........(..((.......)).(((.......)))....).......).)))....)........(.((.(((((((...............))))))).)).)....)....(((..(...(...(((...(((.((((((((...(..........)......)))))))).))).......((....))....)))..)...)...))..)).)...)).)....((((((....(...((((.........))))...).))))))......{...(((.((..((..(.((((((.((((......)))))))))).)..))....((..]]))...))...].))))).).(((......((.(....).))....)))...]]].]((((..(((((((..((..((.((..(((..(((((.......(........)...........(((((.(....(((((........((.(((........))).))......)))))...((.(((...(.((((((....((..(((((....)))..(.((......)))...))..))....(((...(...((.(..(((((((((((((....).)))).)))).....))))..).))..).....(((((.....)))))........)))....))).))).....).))))).....).)))))...)).)))..))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....((((............)))).....)..)..)).)).....((((((((.......))))))))......))...))))))).)).))..(.(..((.(..((((.((..(.((((((((.(((..((((.((...(((((..(((())))....)))))...)).))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}........ mRNA decoding in human is kinetically and structurally distinct from bacteria (IC state); 18S rRNA 8g5y L8 156 2.29 RF00002,RF02540 URS00004B2C76_9606 37020024 0003735 0005840 9606 cgacucuuagcggnggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauuncaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<<<<....>>>>.....<.<<<......>>.............>>>..>...>>>....<<....>><<<<<<<<<.....>>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))(((((((((.....))))))))).................... mRNA decoding in human is kinetically and structurally distinct from bacteria (IC state); 5.8S rRNA 8g5y L5 3721 2.29 RF02543 URS00026813F0_9606 37020024 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagngngaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcgcggcggaucuuucccggcgggggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucgggggcccccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcgcucuccccccugggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccggggggccacgcgcgcgucccccgaagagggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccnucuugnaacncggaccaaggagunuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccnanagauggugancuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauagnggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcagacccgacgccacgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcngaacuggcgnugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagcggcgggcccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaunuuggugguagunnnaaauauucaaacgagaacuuugaaggccgaaguggngaaggguuccaugngaacagnanuugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggagcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccnuauccgcagcaggucuncaaggugaacngccucuggnauguuggaacaanguagguaagggaagucggcaagcnggauccguaacuucnggauaaggauuggcucuaagggcugguagcagccgacuuagaacuggugcggaccaggngaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugccnagugcucugaaugucanagugnngaaauucaaugaagcgcggnuaaacggcgggaguancuaugacucucuuaagguagcnaanugccucnucaucuaauuagugangcgcaugaanggaugancgagnuucccacugunccuaccuacuauccagcgaaaccacngncaagggaacgggcuuggnggaaucagcggngaaagaagacccuguugagcuugacncuagucuggcacggugaanagacaugagagguguagaauaagugggaggcccccggcgcccccccgguguccccgcgaggggcccggggcgggguccgccggcccugcgggccgccggugaaauaccacuacucugaucguuuuuucacugacccggugaggcgggggggcgagccccgaggggcucucgcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacugnggcgguacaccugucaaacgguancgcaggnnuccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucagnacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggangugucagaaaaguuaccacagngauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuungaugucggnucuuccuaucauugugaagcagaauucaccaagcguungaunnuucacccacuaauagggaacgugngcugggnuuagancgucgugagacagguuaguuuuacccuacugaugnuguguuguugccaugguanuccugcucaguacgagaggaaccgcagnuncanacauuugguguaunugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccggucccccgcgggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<...<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>...<<<<<<<<<<...<<<<<<<<.<<.....<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>.>>>>>>>>>>..>>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<<<..<<<<<<<...<<<...<<<<<.<<<..<<<...>>>>>>>>>>>..>>>..>>>>...>>>>>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<.<<<<<<<<<<<<<<<...<<..<<<..<.<<<<......<<<<<<<<..>>>>>>>>.......>>>>.>.>>>........>>>>>>..>>>>>>>>>>>....................<<<<<<.<<<<<<..>>>>>>.<<<<<<.<<<<.<<<<<<<<<<<<<<<<.<<<<<<<.<<<<....>>>>.>>>>>>>.>>>.>>>>>>>>>>.>>>...>>>>>>>>.>>..<<<<<<<<<<.....>>>>>>>>.>>....>>>>>>......>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<<....>>>>>>>>..<<<<<...<<<..<<<..((((.(((.>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<..................<<<.<<<<<<<<<...<<<....<<<..<.<<<..<<<<<<.<<...>>.>>>>>>>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.........>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<........<<<<.<<....<<.........>>....>>.........<<......>>...>>>>....>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<...........))).)))).....................>>>>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<<<<<...>>>>>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<.<<<<<..<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<...............<<<<<...............>>>>><<.<<<<<<<<<<<....>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<<<<<<.<<<<...........<..<<...............................................................................>>..>.>>>>.>>.>>>>>>>>>>...<<<<<.....<<<<..<<.<<............>>>>..............<<<<<<<<<<<.....>>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>><<<<....>>>>>>)))].....<<<<<<<..<<<..)))))).>>>>>>>>>>.........>>>>..>>>>>>.......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<....<<<<<.................>>>>>..<<<<....<<<<....<<.<<<<<<<]]].>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.....<<<<<<<.<<..<<<<....<<<........<<<<<.<<<<...>>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>..............>>>>..>>>>>>>>><<<<<....................<<.<<<<<<<.<<.....<<<<.<..<<<<<......>>>>>..>>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..(((((((((((.....)))))).))))....))))....((((((((((...(((((.((.((.(...((((((((..({((((......)))))....[[(...).(((....}]])))...).)))))))))))).)))))..))))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((..(...((((((((.(((.....(((((((((((..((((((....(((.(.(((((.(((..(((...)))))))))))).)))...)))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((....((((......((((((((())))))))).......))))...)))........))))))..)))))))))))....................((((((.((((((())))))).((((((.((((.((((((((((((((((..((((((.((((....)))).))))))..))).)))))))))).)))...)))))))).))..((((((((((.....)))))))).))..[.)))))).....))).)))))...).)))...)))))))).<((((........))))((((((....(((((((((((((..(((..((((..........)))..)..)))...((....))...((((((((....))))))))..(((((...(((..(((..[[[[.[[[.)))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((..................(((.((((((((.....((.....((.....((..((((((.((...)).)))))))).....))...))......))))))...(((((((((.(......))))))))))....))))))))))))..))..((((..(.((.....)).)..))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.....{..((((..((...((.........))...))......(...((......)).).))))....)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((...........]]].]]]]].......(...)........)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((..(((((((...((.....)).))))))....[[(((.((...(.....(((....)))...(.)....((.((((.(.((...)).).)))))).......)....))...(((((........)))))]]((((.(((((...(((((((....)))))))..((((....)))...(...((((((...((((((((((((((((((((((...{{{...)))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).))).))).....((......)).)))).((((.....))))..)))....(((......(.(((...((..(....(.......(((((....(.[..).....)))))((.(((((((((((....)))))..)))))).))(...).......(((((((((.>.(...........)...(((((((....((((.....))))......))))))).].(.(.(((..((((((.(...(......(((......)))......).)))))..)))))(.(.(.........).).)........((..........(((((.......)))))..)..)....).)....)).))))))).)..)))...))).)...)))))....)).[..((.((.....>].)).)).....((((..(((.((......((((.(((((...(((((.(((((((((.((((((((((((.((((...........(..((...............................................................................))..).)))).)).))))))))))...(((((.....((((..((.((............))))..............(((((((((((.....)))))))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(..((....((....{..))....)).)(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}.....)))..)))))).......(....(.((((.(...((.......))...).))))...)....)........((((.((((((..(.(.(.(((......))).)...).)..((.(.....).))......)))))..)...))).)......((((((....))).)))...a.))..))).))))......(.((.(.(..(((..(.(((((......(....).....))))).)(((.....((((....((.(((((((}}}.)))))..)).))...))))....))).(((....((((.....}.......))))....)))..)))...).).)).).....(((((((.((..((((.(..(((........(((((.((((...)))).))))).......)))...(((..((((....((((.(((((((......)))))))))))...))))..)))...........)..))))..)))))))))(((((....(.......).......((.(((((((.((.....(.((.(..(((((......)))))..))).)....))....)))).))).))..))))).. mRNA decoding in human is kinetically and structurally distinct from bacteria (IC state); 28S rRNA 8g5y L7 120 2.29 RF00001 URS000002B0D5_9606 37020024 0003735 0005840 9606 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. mRNA decoding in human is kinetically and structurally distinct from bacteria (IC state); 5S rRNA 8g5y Pt 77 2.29 RF00005 URS000057545F_9606 37020024 0030533 0006412 9606 cgcggggnggagcagcccggnagcucgucgggnucauaacccgaagnucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... mRNA decoding in human is kinetically and structurally distinct from bacteria (IC state); P-site tRNA 8g5z S2 1701 2.64 RF01960,RF02542,RF01959,RF00177 URS00026813E7_9606 37020024 0003735 0005840 9606 uaccugguugauccugccaguagcaunugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucnuuaaaucaguuauggunccuunggucgcucgccacuuggauaacugugguanuucuagngcuaananaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgccccccguggcggcgacgacccauucgaacgucngcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgaunccggaganggagccugagaaacggcuaccacauncaaggnaggcagcaggcgcgcnaauuacccacucccgacccggggangungugangaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaanuccuuuaacgaggnuccauuggagngcaagucuggugccagcagccgcggnaauuccagcuccaauancguauauuaaaguugcugcaguunaaaagcucguaguungaucuugggagcgggcguccccgccuuuacuuugaaaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaaungaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagancgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacncaacacgggaaaccucacccggcccggacacggacagganugacagauugauagcucuuucucgauuccguggguggngnugcauggcnguucuuaguugguggagcgauuugucugguuaauuccgauaacgancgagacunuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuncuuanagggacaaguggcguucagccacccgagauugagcaauaacangucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgagnaauucccaguaagugcgggucauaagcuugcguugauunagucccugcccuuuguacacaccgnccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggugcccuggcggagcgcugagaagacggucgaacungacuaucuagaggaaguaaaagucguancaagguuucnguaggugnnccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<....<<....<<<<<..........<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<<......>>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<<......>>>>>>>>.>>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....<<<<<<<<<.<<<....>>>..>>>>>.>>>>......<<..<...........>..>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<........................<<<<<<.<.......<<...<.......>.<<<<.......>>>>...>>......>.>>>..>>>........<.<<.<<<<<<<...............>>>>>>>.>>.>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<......>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<.......<<........>>..........<<<<<......<<<<<<.......<<.<<<........>>>.>>.....>>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<.......>>>>.>>>>.....>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>>......>>>>>....>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>............<<<<<..........>>>>>...........>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<.<<<<<..........>>>>>...>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))((...(((((......(..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..((....((((....((.....((.....((.(((.....))).))......))......)).((((...(((((......)))))...))))((..(((((...(......)..)))))......)).(.((((.((((......))))))))).).)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)........(((((((((.(((....)))..))))).))))....(.((..(...........)..))......)..((((([[....(.(.((.....((..]])).......)).)))))))..)))))...))..[......(.([[...(.(.((...(.(..(........................(..(((.(........(..((.......)).(((.......)))....).......).)))....)........(.((.(((((((...............))))))).)).)....)....(((.((...(...(((...(((.((((((((...(..........)......)))))))).))).......((....))....)))..)...))..))..)).)...)).)....((((((....(...((((.........))))...).))))))......{...(((.((..((..(.((((((.((((......)))))))))).)..))....((..]]))...))...].))))).).(((......((.(....).))....)))...]]].]((((..(((((((..((..((.((..(((..(((((.......(........)...........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....((..(((((....)))..(.((......)))...))..))....(((...(...((.(..(((((((((((((....).)))).)))).....))))..).))..).....(((((.....)))))........)))....))).))).....).))))).....).)))))...)).)))..))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....((((............)))).....)..)..)).)).....((((((((.......))))))))......))...))))))).)).))..(.(..((.(..((((.((..(.((((((((.(((..((((.((...(((((.(((((..........)))))...)))))...)).))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}........ mRNA decoding in human is kinetically and structurally distinct from bacteria (GA state); 18S rRNA 8g5z L8 156 2.64 RF00002,RF02540 URS00004B2C76_9606 37020024 0003735 0005840 9606 cgacucuuagcggnggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauuncaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<<<<....>>>>.....<.<<<......>>.............>>>..>...>>>....<<....>><<<<<<<<<.....>>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))(((((((((.....))))))))).................... mRNA decoding in human is kinetically and structurally distinct from bacteria (GA state); 5.8S rRNA 8g5z L5 3687 2.64 RF02543 URS00026813E5_9606 37020024 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagngngaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcgcggcggaucuuucccgcgggggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucgggggcccccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcgcucuccccccugggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccggggggccacgcgcgcgucccccgaagagggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccnucuugnaacncggaccaaggagunuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccnanagauggugancuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauagnggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcagacccgaacgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcngaacuggcgnugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagcggcgggccggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaunuuggugguagunnnaaauauucaaacgagaacuuugaaggccgaaguggngaaggguuccaugngaacagnanuugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggagcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccnuauccgcagcaggucuncaaggugaacngccucuggnauguuggaacaanguagguaagggaagucggcaagcnggauccguaacuucnggauaaggauuggcucuaagggcugggucggucgcggccggcgccuagcagccgacuuagaacuggugcggaccaggngaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugccnagugcucugaaugucanagugnngaaauucaaugaagcgcggnuaaacggcgggaguancuaugacucucuuaagguagcnaanugccucnucaucuaauuagugangcgcaugaanggaugancgagnuucccacugunccuaccuacuauccagcgaaaccacngncaagggaacgggcuuggnggaaucagcggngaaagaagacccuguugagcuugacncuagucuggcacggugaanagacaugagagguguagaauaagugggaggcccgggccgccggugaaauaccacuacucugaucguuuuuucacugacccggugaggcgggggggcgagccccgaggggcucucgcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacugnggcgguacaccugucaaacgguancgcaggnnuccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucagnacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggangugucagaaaaguuaccacagngauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuungaugucggnucuuccuaucauugugaagcagaauucaccaagcguungaunnuucacccacuaauagggaacgugngcugggnuuagancgucgugagacagguuaguuuuacccuacugaugnuguguuguugccaugguanuccugcucaguacgagaggaaccgcagnuncanacauuugguguaunugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccggucccccgccgggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<<...<<<<<<<<<<<...>>>>>>>.>>>>.....>>>>>..<<<<<<<<<<...<<<<<.<<.<<.....<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>.>>>>.>>>>>..>>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<.<....<<<<<<<<.<<<.....<<<<<<<<<<<..<<<<<<<.<<<<<...<<<<<.<<<..<<<..>>>>>>>>>>>..>>>>>>>>>...>>>>>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<<<<<<<<<<<<.<<<<...<<..<<<.<<.<<<<......<<<<<<<<..>>>>>>>>.......>>>>>>.>>>........>>>>>>...>>>>>>>>>>....................<<<<<<.<<<<<<..>>>>>>.<<<<<<.<<<<.<<<<<<<<<<<<<<<<<<<<<<<<.<<<<....>>>>.>>>>>>>>>>>.>>>>>>>>>>.>>>...>>>>>>>>.>>..<<<<<<<<<<.....>>>>>>>>.>>....>>>>>>.....>>>.>>>>>....>>>>...>>>>>>>>..<<<<........>>>><<<<<<...<<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<<....>>>>>>>>..<<<<<...<<<..<<<..((((.(((.>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>>.<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<..............<<<.<<<<<<<<<...<<<....<<<..<.<<<..<<<<<<.<.....>.>>>>>>>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.........>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<...........))).))))............................>>>>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<<<.<....>>>>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<.<<<<<..<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<...............>>>>><<.<<<<<<<<<<<.......................>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<<<<.<<.<<<..........<<<<<........................>>>>>.>>>>>...>>>>>>>>>>...<<<<<.....<<<<..<<.<<<<<......>>>>>>>..............<<<<<<<<<<<.....>>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>><<<<....>>>>>>)))].....<<<<<<<..<<<..)))))).>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<]]].>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.....<<<<<<<.<<..<<<<....<<<........<<<<<.<<<<....>>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>..............>>>>..>>>>>>>>><<<<<....................<<.<<<<<<<.<<.....<<<<....<<<<<......>>>>>...>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..((((((((((((...))))))).))))....))))....((((((((((...(((((.((.((.....((((((((..({((((......)))))....[[(...).(((....}]])))...).))))))).)))).)))))..))))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....(((((((((((..((.(((...((.....(((((.(((..(((..)))))))))))....))..)))....)))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((.((.((((......((((((((..)))))))).......)))))).)))........))))))..)))))))))))......{.............((((((.((((((())))))).((((((.((((.((((((((((((((((((((((((.((((....)))).))))))))))).)))))))))).)))...)))))))).))..((((((((((.....)))))))).))..[.)))))).....))).)))))...)))))...)))))))).<((((........))))((((((....(((((((((((((..(((..(((((........))))..)..)))...((....))...((((((((....))))))))..(((((...(((..(((..[[[[.[[[.)))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......B)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((..............(((.((((((((.....((.....((.....((..(((((..(.....)..))))))).....))...))......))))))...(((((((((.(......))))))))))....))))))))))))..))..((((..(.((.....)).)..))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.....A.(((((..((...((.........))...))......(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((........}..]]].]]]]]..............(...)........)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((..(((((((...((.....)).))))))....[[(((.((...(.....(((....)))...(.)....((.(((((((.......))))))))).......)....))...(((((........)))))]]((((.(((((...(((((((....)))))))..((((....)))...(...((((((...((((((((((((((((((((((...{{{...)))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).))).))).....((......)).)))).((((.....))))..)))....(((......(.(((...((..(....(.......(((((....(.[..).....)))))((.(((((((((((.......................)))))..)))))).))(...).......(((((((((.>.(...........)...(((((((....((((.....))))......))))))).].(.(.(((..((((((.(...(......(((......)))......).)))))..)))))(.(.(.........).).)........((..........(((((.......)))))..)..)....).)....)).))))))).)..)))...))).)...)))))....)).[..((.((.....>].)).)).....((((..(((.((......((((.(((((...(((((.(((((((((.(((((((.((.((.(((..........(((((........................))))).)))))...)).)))))))...(((((.....((((..((.(((((......)))))))..............(((((((((((.....)))))))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(..((....((....{..))....)).)(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}.....)))..)))))).......(....(.((((.(...((.......))...).))))...)....)........((((.((((((..(.(.(.(((......))).)...).)..((.(.....).))......)))))..)...))).)......((((((....))).)))...b.))..))).))))......(.((.(.(..(((..(.(((((......(....).....))))).)(((.....((((....((.(((((((}}}.)))))..)).))...))))....))).((((...((((.....a.......))))...))))..)))...).).)).).....(((((((.((..((((.(..(((........(((((.((((....)))).))))).......)))...(((..((((....((((.(((((((......)))))))))))...))))..)))...........)..))))..)))))))))(((((....(.......).......((.(((((((.((.....(.((.(..(((((......)))))..))).)....))....)))).))).))..))))).. mRNA decoding in human is kinetically and structurally distinct from bacteria (GA state); 28S rRNA 8g5z L7 120 2.64 RF00001 URS000002B0D5_9606 37020024 0003735 0005840 9606 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. mRNA decoding in human is kinetically and structurally distinct from bacteria (GA state); 5S rRNA 8g5z mR 11 2.64 37020024 9606 cguauguucaa ........... ........... mRNA decoding in human is kinetically and structurally distinct from bacteria (GA state); mRNA 8g5z At 76 2.64 RF00005 URS00005AA258_562 37020024 0030533 0006412 562 gcccgganagcucagncggnagagcaggggauugaanauccccgunuccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>><<<<<<<.....>>>>>>.>...<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..))))(((((.........)))).)...(((((..]....)))))))))))).... mRNA decoding in human is kinetically and structurally distinct from bacteria (GA state); A-site tRNA Phe 8g5z Pt 77 2.64 RF00005 URS000057545F_562 37020024 0030533 0006412 562 cgcggggnggagcagcccggnagcucgucgggnucauaacccgaagnucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... mRNA decoding in human is kinetically and structurally distinct from bacteria (GA state); P-site tRNA fMet 8g60 S2 1654 2.54 RF01960,RF02542,RF01959,RF00177 URS00026813DB_9606 37020024 0003735 0005840 9606 uaccugguugauccugccaguagcaunugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucnuuaaaucaguuauggunccuunggucgcucccacuuggauaacugugguanuucuagngcuaananaugccgacgggcgcugacccgggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgccccccguggcggcgacgacccauucgaacgucngcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgaunccggaganggagccugagaaacggcuaccacauncaaggnaggcagcaggcgcgcnaauuacccacucccgacccggggangungugangaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaanuccuuuaacgaggnuccauuggagngcaagucuggugccagcagccgcggnaauuccagcuccaauancguauauuaaaguugcugcaguunaaaagcucguaguungaucuuguuacuuugaaaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaaungaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagancgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacncaacacgggaaaccucacccggcccggacacggacagganugacagauugauagcucuuucucgauuccguggguggngnugcauggcnguucuuaguugguggagcgauuugucugguuaauuccgauaacgancgagacunuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuncuuanagggacaaguggcguucagccacccgagauugagcaauaacangucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgagnaauucccaguaagugcgggucauaagcuugcguugauunagucccugcccuuuguacacaccgnccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggcccgagcgcugagaagacggucgaacungacuaucuagaggaaguaaaagucguancaagguuucnguaggugnnccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<....<<....<<<<<.........<<.....<<.<<.......>>.>>......>>.........<<<<...<<...>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<<......>>>>>>>>.>>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....<<<<<<<<<.<<<....>>>..>>>>>.>>>>......<<..<...........>..>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<.....<<<<<<.<.......<<...<.......>.<<<<.......>>>>...>>......>.>>>..>>>........<.<<.<<<<<<<...............>>>>>>>.>>.>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<<....>>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<......>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<.......<<........>>..........<<<<<.<....<<<<<<.......<<.<<<........>>>.>>.....>>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<.......>>>>.>>>>.....>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>>....>.>>>>>....>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<......>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))((...(((((......(..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..((....(((((...(.....((.....((.(((.....))).))......)).......).((((...(((.)))...))))((..(((((...(......)..)))))......)).(.((((.(((((...).))))))))))).)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)........(((((((((..((....))...))))).))))....(.((..(...........)..))......)..((((([[....(.(.((.....((..]])).......)).)))))))..)))))...))..[......(.([[...(.(.((...(.(..(.....(..(((.(........(..((.......)).(((.......)))....).......).)))....)........(.((.(((((((...............))))))).)).)....)....(((.((...(...(((...(((.((((((((...(..........)......)))))))).))).......((....))....)))..)...))..))..)).)...)).)....((((((....(...((((.........))))...).))))))......{...(((.((..((..(.((((((.((((......)))))))))).)..))....((..]]))...))...].))))).).(((......((.(....).))....)))...]]].]((((..(((((((..((..((.((..(((..(((((.......(........)...........(((((.(....(((((........((.(((........))).))......)))))...((.(((...(.((((((.(..((..(((((....)))..(.((......)))...))..))....(((...(...((.(..(((((((((((((....).)))).)))).....))))..).))..).....(((((.....)))))........))).)..))).))).....).))))).....).)))))...)).)))..))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....((((............)))).....)..)..)).)).....((((((((.......))))))))......))...))))))).)).))..(.(..((.(..((((.((..(.((((((((.(((..((((.((...((((((().).)))))...)).))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}........ mRNA decoding in human is kinetically and structurally distinct from bacteria (CR state); 18S rRNA 8g60 L8 156 2.54 RF00002,RF02540 URS00004B2C76_9606 37020024 0003735 0005840 9606 cgacucuuagcggnggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauuncaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<<<<....>>>>.....<.<<<......>>.............>>>..>...>>>....<<....>><<<<<<<<<.....>>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))(((((((((.....))))))))).................... mRNA decoding in human is kinetically and structurally distinct from bacteria (CR state); 5.8S rRNA 8g60 L5 3637 2.54 RF02543 URS00026813F0_9606 37020024 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagngngaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcgcggcggaucuuucccggggggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucgggggcccccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcgcucuccccccugggggggccgggccaccccucccacggcgcgaccgcucgggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccggggggccacgcgcgcguccccggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccnucuugnaacncggaccaaggagunuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccnanagauggugancuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauagnggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcagacccgaacgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcngaacuggcgnugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagcgcgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaunuuggugguagunnnaaauauucaaacgagaacuuugaaggccgaaguggngaaggguuccaugngaacagnanuugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggagcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccnuauccgcagcaggucuncaaggugaacngccucuggnauguuggaacaanguagguaagggaagucggcaagcnggauccguaacuucnggauaaggauuggcucuaagggcuggguagcagccgacuuagaacuggugcggaccaggngaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugccnagugcucugaaugucanagugnngaaauucaaugaagcgcggnuaaacggcgggaguancuaugacucucuuaagguagcnaanugccucnucaucuaauuagugangcgcaugaanggaugancgagnuucccacugunccuaccuacuauccagcgaaaccacngncaagggaacgggcuuggnggaaucagcggngaaagaagacccuguugagcuugacncuagucuggcacggugaanagacaugagagguguagaauaagugggaggcccgggccgccggugaaauaccacuacucugaucguuuuuucacugacccggugaggcgggggggcgagccccgaggggcucucgcuucuggcgccaagcgcccggcgccgggcgcgacccgcuccggggacagugccagguggggaguuugacugnggcgguacaccugucaaacgguancgcaggnnuccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucagnacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggangugucagaaaaguuaccacagngauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuungaugucggnucuuccuaucauugugaagcagaauucaccaagcguungaunnuucacccacuaauagggaacgugngcugggnuuagancgucgugagacagguuaguuuuacccuacugaugnuguguuguugccaugguanuccugcucaguacgagaggaaccgcagnuncanacauuugguguaunugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccggucccccgccgggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<<...<<<<<<<<<<<...>>>>>>>.>>>>.....>>>>>..<<<<<<<<<<...<<<<<<<<.<......<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>..>>>>>>>>>..>>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<.<....<<<<<<<<.<<<.....<<<<<<<<<<<..<<<<<<<..<<<<...<<<<<.<<<..<<<.>>>>>>>>>>>..>>>>.>>>>...>>>>>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<.<<<<<<<<<<<<<<<...<<..<<<.<<.<<<<......<<<<<<<<..>>>>>>>>.......>>>>>>.>>>........>>>>>>..>>>>>>>>>>>....................<<<<<<.<<<<<<..>>>>>>.<<<<<<.<<<<.<<<<<<<<<<<<<<<<<<<<<<<.<<<<....>>>>.>>>>>.>>>>>.>>>>>>>>>>.>>>...>>>>>>>>.>>..<<<<<<<<..>>>>>>.>>....>>>>>>......>>.>>>>>....>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<<....>>>>>>>>..<<<<<...<<<..<<<..((((.(((.>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<..............<<<.<<<<<<<<<...<<<....<<<..<.<<<..<<<<<<.<<...>>.>>>>>>>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.........>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<......<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>....>>>>>..>>>...>>>>>>><<<<<<.<<<...........))).))))..............>>>>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<<<.<...>.>>>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<.<<<<<..<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<...............<<<<<....<....>.....>>>>><<.<<<<<<<<<<<.....>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<<<<............................................................>>>>>>>>>>...<<<<<.....<<<<..<<.<<<<<......>>>>>>>..............<<<<<<<<..>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>><<<<....>>>>>>)))].....<<<<<<<..<<<..)))))).>>>>>>>>>>.........>>>>..>>>>>>.......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<]]].>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.....<<<<<<<.<<..<<<<....<<<........<<<<<.<<<......>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>..............>>>>..>>>>>>>>><<<<<....................<<.<<<<<<<.<<.....<<<<....<<<<<......>>>>>...>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..((((((.(((((...))))).).))))....))))....((((((((((...(((((.(.....(...((((((((..({((((......)))))....[[(...).(((....}]])))...).))))))))...).)))))..))))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....(((((((((((..((((((...((((.(.(((((.(((..(((.)))))))))))).))))..)))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((.((.((((......((((((((..)))))))).......)))))).)))........))))))..)))))))))))......{.............((((((.((((((())))))).((((((.((((.(((((((((((((.(((((((((.((((....)))).))))).))))..)))))))))).)))...)))))))).))..((((((((())))))).))..[.)))))).....))).)))))...)))))...)))))))).<((((........))))((((((....(((((((((((((..(((..(((((........))))..)..)))...((....))...((((((((....))))))))..(((((...(((..(((..[[[[.[[[.)))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......B)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((..............(((.((((((((.....((.....((.....(((..(((((.((...)).)))))))).....))...))......))))))...(((((((((.(......))))))))))....))))))))))))..))..((((..(.((.....)).)..))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.....A.(((((.(((...(...........)...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((........}..]]].]]]]].............)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((..(((((((...((.....)).))))))....[[(((.((...(.....(((....)))...(.)....((.((((((.........)))))))).......)....))...(((((........)))))]]((((.(((((...(((((((....)))))))..((((....)))...(...((((((...((((((((((((((((((((((...{{{...)))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).))).))).....((......)).)))).((((.....))))..)))....(((......(.(((...((..(....(.......(((((....(.[..).....)))))((.(((((((((((.....)))))..)))))).))(...).......(((((((((.>.(...........)...(((((((....((((.....))))......))))))).].(.(.(((..((((((.(...(......(((......)))......).)))))..)))))(.(.(.........).).)........((..........(((((.......)))))..)..)....).)....)).))))))).)..)))...))).)...)))))....)).[..((.((.....>].)).)).....((((..(((.((......((((.(((((...(((((.(((((((((.(((((((.((............................................................)).)))))))...(((((.....((((..((.((((........))))))..............((((((((()))))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(..((....((....{..))....)).)(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}.....)))..)))))).......(....(.((((.(...((.......))...).))))...)....)........((((.((((((..(.(.(.(((......))).)...).)..((.(.....).))......)))))..)...))).)......((((((....))).)))...b.))..))).))))......(.((.(.(..(((..(.(((((......(....).....))))).)(((.....((((....((.(((((((}}}.)))))..)).))...))))....))).((((...((((.....a.......))))...))))..)))...).).)).).....(((((((.((..((((.(..(((........(((((.(((......))).))))).......)))...(((...(((....((((.(((((((......)))))))))))...)))...)))...........)..))))..)))))))))(((((....(.......).......((.(((((((.((.....(.((.(..(((((......)))))..))).)....))....)))).))).))..))))).. mRNA decoding in human is kinetically and structurally distinct from bacteria (CR state); 28S rRNA 8g60 L7 120 2.54 RF00001 URS000002B0D5_9606 37020024 0003735 0005840 9606 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. mRNA decoding in human is kinetically and structurally distinct from bacteria (CR state); 5S rRNA 8g60 At 76 2.54 RF00005 URS00005AA258_9606 37020024 0030533 0006412 9606 gcccgganagcucagncggnagagcaggggauugaanauccccgunuccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<.........>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..))))(((((.........)))).)...(((((..]....)))))))))))).... mRNA decoding in human is kinetically and structurally distinct from bacteria (CR state); A-site tRNA 8g60 Pt 77 2.54 RF00005 URS000057545F_9606 37020024 0030533 0006412 9606 cgcggggnggagcagcccggnagcucgucgggnucauaacccgaagnucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(((((.......)))))))))))..... mRNA decoding in human is kinetically and structurally distinct from bacteria (CR state); P-site tRNA 8g61 S2 1682 2.94 RF01960,RF02542,RF01959,RF00177 URS00026813DB_9606 37020024 0003735 0005840 9606 uaccugguugauccugccaguagcaunugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucnuuaaaucaguuauggunccuunggucgcucgccacuuggauaacugugguanuucuagngcuaananaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgccccccguggcggcgacgacccauucgaacgucngcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgaunccggaganggagccugagaaacggcuaccacauncaaggnaggcagcaggcgcgcnaauuacccacucccgacccggggangungugangaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaanuccuuuaacgaggnuccauuggagngcaagucuggugccagcagccgcggnaauuccagcuccaauancguauauuaaaguugcugcaguunaaaagcucguaguungaucuuguuacuuugaaaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaaungaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagancgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacncaacacgggaaaccucacccggcccggacacggacagganugacagauugauagcucuuucucgauuccguggguggngnugcauggcnguucuuaguugguggagcgauuugucugguuaauuccgauaacgancgagacunuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuncuuanagggacaaguggcguucagccacccgagauugagcaauaacangucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgagnaauucccaguaagugcgggucauaagcuugcguugauunagucccugcccuuuguacacaccgnccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggugcccuggcggagcgcugagaagacggucgaacungacuaucuagaggaaguaaaagucguancaagguuucnguaggugnnccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<.<..<<....<<<<<..........<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<<......>>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<<......>>>>>>>>.>>.>>>...>>>.>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....<<<<<<<<<.<<<....>>>..>>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<.....<<<<<<.<.......<<...<.......>.<<<<.......>>>>...>>......>.>>>..>>>........<.<<.<<<<<<<...............>>>>>>>.>>.>....>>....<<<<<<..<...<<<<..<<<.<<<<<<<<...<<<......>>>......>>>>>>>>.>>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<.......>>>>.>>>>.....>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<.<<<<<..........>>>>>...>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))((...(((((......(..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..((....(((((...((.....((.....((.(((.....))).))......))......)).((((...(((((......)))))...))))((..(((((...(......)..)))))......)).(.((((.((((......))))))))))).)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)........(((((((((.(((....)))..)))))).)))....(.(...(...........)...)......)..((((([[....(.(.((.....((..]])).......)).)))))))..)))))...))..[......(.([[...(.(.((...(.(..(.....(..(((.(........(..((.......)).(((.......)))....).......).)))....)........(.((.(((((((...............))))))).)).)....)....(((.((...(...(((...(((.((((((((...(..........)......)))))))).))).......((....))....)))..)...))..))..)).)...)).)....((((((....(...((((.........))))...).))))))......{...(((.((..((..(.((((((.((.(......).)))))))).)..))....((..]]))...))...].))))).).(((......((.(....).))....)))...]]].]((((..(((((((..((..((.((..(((..(((((.......(........)...........(((((.(....(((((........((.(((........))).))......)))))...((.(((...(.((((((....((..(((((....)))..(.((......)))...))..))....(((...(...((.(..(((((((((((((....).)))).)))).....))))..).))..).....(((((.....)))))........)))....))).))).....).))))).....).)))))...)).)))..))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....((((............)))).....)..)..)).)).....((((((((.......))))))))......))...))))))).)).))..(.(..((.(..((((.((..(.((((((((.(((..((((.((...(((((.(((((..........)))))...)))))...)).))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}........ mRNA decoding in human is kinetically and structurally distinct from bacteria (AC state); 18S rRNA 8g61 L8 156 2.94 RF00002,RF02540 URS00004B2C76_9606 37020024 0003735 0005840 9606 cgacucuuagcggnggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauuncaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<<<<....>>>>.....<.<<<......>>.............>>>..>...>>>....<<....>><<<<<<<<<.....>>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))(((((((((.....))))))))).................... mRNA decoding in human is kinetically and structurally distinct from bacteria (AC state); 5.8S rRNA 8g61 L5 3657 2.94 RF02543 URS00026813F0_9606 37020024 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagngngaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcgcggcggaucuuucccgcgggggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucgggggccccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcgcucuccccccugggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccggggggccacgcgcgcgucccccgaagagggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccnucuugnaacncggaccaaggagunuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccnanagauggugancuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauagnggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcagacccgaacgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcngaacuggcgnugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagcggccccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaunuuggugguagunnnaaauauucaaacgagaacuuugaaggccgaaguggngaaggguuccaugngaacagnanuugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggagcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccnuauccgcagcaggucuncaaggugaacngccucuggnauguuggaacaanguagguaagggaagucggcaagcnggauccguaacuucnggauaaggauuggcucuaagggcugguagcagccgacuuagaacuggugcggaccaggngaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugccnagugcucugaaugucanagugnngaaauucaaugaagcgcggnuaaacggcgggaguancuaugacucucuuaagguagcnaanugccucnucaucuaauuagugangcgcaugaanggaugancgagnuucccacugunccuaccuacuauccagcgaaaccacngncaagggaacgggcuuggnggaaucagcggngaaagaagacccuguugagcuugacncuagucuggcacggugaanagacaugagagguguagaauaagugggaggcccgggccgccggugaaauaccacuacucugaucguuuuuucacugacccggugaggcgggggggcgagccccgaggggcucucgcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacugnggcgguacaccugucaaacgguancgcaggnnuccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucagnacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggangugucagaaaaguuaccacagngauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuungaugucggnucuuccuaucauugugaagcagaauucaccaagcguungaunnuucacccacuaauagggaacgugngcugggnuuagancgucgugagacagguuaguuuuacccuacugaugnuguguuguugccaugguanuccugcucaguacgagaggaaccgcagnuncanacauuugguguaunugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccggucccccgccgggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<<...<<<<<<<<<<<...>>>>>>>.>>>>.....>>>>>..<<<<<<<<<<...<<<<<<<<.<......<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>..>>>>>>>>>..>>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<<<..<<<<<<<.<<<<<...<<<<<.<<<..<<<..>>>>>>>>>>>..>>>>>>>>>...>>>>>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<.<<<<<<<<<<<<<<<...<<..<<<.<<.<<<<......<<<<<<<<.>>>>>>>>.......>>>>>>.>>>........>>>>>>..>>>>>>>>>>>....................<<<<<<.<<<<<<..>>>>>>.<<<<<<.<<<<.<<<<<<<<<<<<<<<<<<<<<<<<.<<<<....>>>>.>>>>>>>>>>>.>>>>>>>>>>.>>>...>>>>>>>>.>>..<<<<<<<<<<.....>>>>>>>>.>>....>>>>>>......>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<<<<...<<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<<....>>>>>>>>..<<<<<...<<<..<<<..((((.((((>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>>.<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<..............<<<.<<<<<<<<<...<<<....<<<..<.<<<..<<<<<<.<<...>>.>>>>>>>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<..........)))).))))..................>>>>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<<<.<....>>>>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<.<<<<<..<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<.<<<<<<<<<<<....>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<<<<<<.<<<<..........<<<<<........................>>>>>.>>>>.>>.>>>>>>>>>>...<<<<<.....<<<<.....<<<<<......>>>>>................<<<<<<<<<<<.....>>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>><<<<....>>>>>>)))].....<<<<<<<..<<<..)))))).>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<]]].>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.....<<<<<<<.<<..<<<<....<<<........<<<<<.<<<<....>>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>..............>>>>..>>>>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<.<..<<<<<......>>>>>..>>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..(((((((((((.....)))))).))))....))))....((((((((((...(((((.(.(...(...((((((((..({((((......)))))....[[(...).(((....}]])))...).))))))))..)).)))))..))))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....(((((((((((..((((((...((((.(.(((((.(((..(((..)))))))))))).))))..)))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((.((.((((......((((((((.)))))))).......)))))).)))........))))))..)))))))))))......{.............((((((.((((((())))))).((((((.((((.((((((((((((((((((((((((.((((....)))).))))))))))).)))))))))).)))...)))))))).))..((((((((((.....)))))))).))..[.)))))).....))).)))))...)))))...)))))))).<((((........))))((((((..(.(((((((((((((..(((..(((((........))))..)..)))...((....))...((((((((....))))))))..(((((...(((..(((..[[[[.[[[[)))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......B)))).)))..).))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((.(((((((..............(((.((((((((.....((.....((.....(((..(((((.((...)).)))))))).....))...))......))))))...(((((((((.(......))))))))))....))))))))))))..))..((((..(.((.....)).)..))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.....A.(((((..((...((.........))...))......(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((........}.]]]].]]]]]....(...)........)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((..(((((((...((.....)).))))))....[[(((.((...(.....(((....)))..........((.((((.((.......)).)))))).......)....))...(((((........)))))]]((((.(((((...((.((((....)))).))..((((....)))...(...((((((...((((((((((((((((((((((...{{{...)))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).))).))).....((......)).)))).((((.....))))..)))....(((......(.(((...((..(....(.......(((((....(.[..).....)))))((.(((((((((((....)))))..)))))).))(...).......(((((((((.>.(...........)...(((((((....((((.....))))......))))))).].(.(.(((..((((((.....(......(((......)))......)..))))..)))))(.(.(.........).).)........((..........(((((.......)))))..)..)....).)....)).))))))).)..)))...))).)...)))))....)).[..((.((.....>].)).)).....((((..(((.((......((((.(((((...(((((.(((((((((.(((((.((((((.((((..........((((..........................)))).)))).)).)))).)))))...(((((.....((((.....(((.(......).)))................(((((((((((.....)))))))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(..((....((....{..))....)).)(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}.....)))..)))))).......(....(.((((.(...((.......))...).))))...)....)........((((.((((((..(.(.(.(((......))).)...).)..((.(.....).))......)))))..)...))).)......((((((....))).)))...b.))..))).))))......(.((.(.(..(((..(.(((((......(....).....))))).)(((.....((((....((.(((((((}}}.)))))..)).))...))))....))).((((...((((.....a.......))))...))))..)))...).).)).).....(((((((.((..((((.(..(((........(((((.((((....)))).))))).......)))...(((..((((....((((.(((((((......)))))))))))...))))..)))...........)..))))..)))))))))(((((....(.......).......((.(((((((.((.....(.((.(..(((((......)))))..))).)....))....)))).))).))..))))).. mRNA decoding in human is kinetically and structurally distinct from bacteria (AC state); 28S rRNA 8g61 L7 120 2.94 RF00001 URS000002B0D5_9606 37020024 0003735 0005840 9606 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. mRNA decoding in human is kinetically and structurally distinct from bacteria (AC state); 5S rRNA 8g61 mR 10 2.94 37020024 9606 cguauguuca .......... .......... mRNA decoding in human is kinetically and structurally distinct from bacteria (AC state); mRNA 8g61 At 76 2.94 RF00005 URS00005AA258_562 37020024 0030533 0006412 562 gcccgganagcucagncggnagagcaggggauugaaaauccccgunuccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((............)).((((.........)))).....(((((.......)))))))))))).... mRNA decoding in human is kinetically and structurally distinct from bacteria (AC state); A-site tRNA 8g61 Pt 77 2.94 RF00005 URS000057545F_562 37020024 0030533 0006412 562 cgcggggnggagcagcccggnagcucgucgggnucauaacccgaagnucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(((((.......)))))))))))..... mRNA decoding in human is kinetically and structurally distinct from bacteria (AC state); RNA (77-MER) 8g6j S2 1701 2.8 RF01960,RF02542,RF01959,RF00177 URS00026813DB_9606 37020024 0003735 0005840 9606 uaccugguugauccugccaguagcaunugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucnuuaaaucaguuauggunccuunggucgcucgccacuuggauaacugugguanuucuagngcuaananaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgccccccguggcggcgacgacccauucgaacgucngcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgaunccggaganggagccugagaaacggcuaccacauncaaggnaggcagcaggcgcgcnaauuacccacucccgacccggggangungugangaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaanuccuuuaacgaggnuccauuggagngcaagucuggugccagcagccgcggnaauuccagcuccaauancguauauuaaaguugcugcaguunaaaagcucguaguungaucuugggagcgggcguccccgccuuuacuuugaaaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaaungaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagancgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacncaacacgggaaaccucacccggcccggacacggacagganugacagauugauagcucuuucucgauuccguggguggngnugcauggcnguucuuaguugguggagcgauuugucugguuaauuccgauaacgancgagacunuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuncuuanagggacaaguggcguucagccacccgagauugagcaauaacangucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgagnaauucccaguaagugcgggucauaagcuugcguugauunagucccugcccuuuguacacaccgnccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggugcccuggcggagcgcugagaagacggucgaacungacuaucuagaggaaguaaaagucguancaagguuucnguaggugnnccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<....<<....<<<<<..........<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<<......>>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<<......>>>>>>>>.>>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....<<<<<<<<<.<<<....>>>..>>>>>.>>>>......<<..<...........>..>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<........................<<<<<<.<.......<<...<.......>.<<<<.......>>>>...>>......>.>>>..>>>........<.<<.<<<<<<<...............>>>>>>>.>>.>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<......>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<.......<<........>>..........<<<<<......<<<<<<.......<<.<<<........>>>.>>.....>>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<.......>>>>.>>>>.....>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>>......>>>>>....>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>............<<<<<..........>>>>>...........>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<.<<<<<..........>>>>>...>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))((...(((((......(..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..((....((((....((.....((.....((.(((.....))).))......))......)).((((...(((((......)))))...))))((..(((((...(......)..)))))......)).(.((((.((((......))))))))).).)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)........(((((((((.(((....)))..))))).))))....(.((..(...........)..))......)..((((([[....(.(.((.....((..]])).......)).)))))))..)))))...))..[......(.([[...(.(.((...(.(..(........................(..(((.(........(..((.......)).(((.......)))....).......).)))....)........(.((.(((((((...............))))))).)).)....)....(((.((...(...(((...(((.((((((((...(..........)......)))))))).))).......((....))....)))..)...))..))..)).)...)).)....((((((....(...((((.........))))...).))))))......{...(((.((..((..(.((((((.((((......)))))))))).)..))....((..]]))...))...].))))).).(((......((.(....).))....)))...]]].]((((..(((((((..((..((.((..(((..(((((.......(........)...........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....((..(((((....)))..(.((......)))...))..))....(((...(...((.(..(((((((((((((....).)))).)))).....))))..).))..).....(((((.....)))))........)))....))).))).....).))))).....).)))))...)).)))..))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....((((............)))).....)..)..)).)).....((((((((.......))))))))......))...))))))).)).))..(.(..((.(..((((.((..(.((((((((.(((..((((.((...(((((.(((((..........)))))...)))))...)).))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}........ mRNA decoding in human is kinetically and structurally distinct from bacteria (GA state 2); 18S rRNA 8g6j L8 156 2.8 RF00002,RF02540 URS00004B2C76_9606 37020024 0003735 0005840 9606 cgacucuuagcggnggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauuncaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<<<<....>>>>.....<.<<<......>>.............>>>..>...>>>....<<....>><<<<<<<<<.....>>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))(((((((((.....))))))))).................... mRNA decoding in human is kinetically and structurally distinct from bacteria (GA state 2); 5.8S rRNA 8g6j L5 3687 2.8 RF02543 URS00026813F0_9606 37020024 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagngngaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcgcggcggaucuuucccgcgggggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucgggggcccccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcgcucuccccccugggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccggggggccacgcgcgcgucccccgaagagggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccnucuugnaacncggaccaaggagunuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccnanagauggugancuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauagnggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcagacccgaacgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcngaacuggcgnugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagcggcgggccggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaunuuggugguagunnnaaauauucaaacgagaacuuugaaggccgaaguggngaaggguuccaugngaacagnanuugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggagcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccnuauccgcagcaggucuncaaggugaacngccucuggnauguuggaacaanguagguaagggaagucggcaagcnggauccguaacuucnggauaaggauuggcucuaagggcugggucggucgcggccggcgccuagcagccgacuuagaacuggugcggaccaggngaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugccnagugcucugaaugucanagugnngaaauucaaugaagcgcggnuaaacggcgggaguancuaugacucucuuaagguagcnaanugccucnucaucuaauuagugangcgcaugaanggaugancgagnuucccacugunccuaccuacuauccagcgaaaccacngncaagggaacgggcuuggnggaaucagcggngaaagaagacccuguugagcuugacncuagucuggcacggugaanagacaugagagguguagaauaagugggaggcccgggccgccggugaaauaccacuacucugaucguuuuuucacugacccggugaggcgggggggcgagccccgaggggcucucgcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacugnggcgguacaccugucaaacgguancgcaggnnuccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucagnacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggangugucagaaaaguuaccacagngauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuungaugucggnucuuccuaucauugugaagcagaauucaccaagcguungaunnuucacccacuaauagggaacgugngcugggnuuagancgucgugagacagguuaguuuuacccuacugaugnuguguuguugccaugguanuccugcucaguacgagaggaaccgcagnuncanacauuugguguaunugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccggucccccgccgggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<<...<<<<<<<<<<<...>>>>>>>.>>>>.....>>>>>..<<<<<<<<<<...<<<<<.<<.<<.....<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>.>>>>.>>>>>..>>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<.<....<<<<<<<<.<<<.....<<<<<<<<<<<..<<<<<<<.<<<<<...<<<<<.<<<..<<<..>>>>>>>>>>>..>>>>>>>>>...>>>>>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<<<<<<<<<<<<.<<<<...<<..<<<.<<.<<<<......<<<<<<<<..>>>>>>>>.......>>>>>>.>>>........>>>>>>...>>>>>>>>>>....................<<<<<<.<<<<<<..>>>>>>.<<<<<<.<<<<.<<<<<<<<<<<<<<<<<<<<<<<<.<<<<....>>>>.>>>>>>>>>>>.>>>>>>>>>>.>>>...>>>>>>>>.>>..<<<<<<<<<<.....>>>>>>>>.>>....>>>>>>.....>>>.>>>>>....>>>>...>>>>>>>>..<<<<........>>>><<<<<<...<<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<<....>>>>>>>>..<<<<<...<<<..<<<..((((.(((.>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>>.<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<..............<<<.<<<<<<<<<...<<<....<<<..<.<<<..<<<<<<.<.....>.>>>>>>>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.........>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<...........))).))))............................>>>>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<<<.<....>>>>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<.<<<<<..<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<...............>>>>><<.<<<<<<<<<<<.......................>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<<<<.<<.<<<..........<<<<<........................>>>>>.>>>>>...>>>>>>>>>>...<<<<<.....<<<<..<<.<<<<<......>>>>>>>..............<<<<<<<<<<<.....>>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>><<<<....>>>>>>)))].....<<<<<<<..<<<..)))))).>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<]]].>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.....<<<<<<<.<<..<<<<....<<<........<<<<<.<<<<....>>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>..............>>>>..>>>>>>>>><<<<<....................<<.<<<<<<<.<<.....<<<<....<<<<<......>>>>>...>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..((((((((((((...))))))).))))....))))....((((((((((...(((((.((.((.....((((((((..({((((......)))))....[[(...).(((....}]])))...).))))))).)))).)))))..))))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....(((((((((((..((.(((...((.....(((((.(((..(((..)))))))))))....))..)))....)))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((.((.((((......((((((((..)))))))).......)))))).)))........))))))..)))))))))))......{.............((((((.((((((())))))).((((((.((((.((((((((((((((((((((((((.((((....)))).))))))))))).)))))))))).)))...)))))))).))..((((((((((.....)))))))).))..[.)))))).....))).)))))...)))))...)))))))).<((((........))))((((((....(((((((((((((..(((..(((((........))))..)..)))...((....))...((((((((....))))))))..(((((...(((..(((..[[[[.[[[.)))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......B)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((..............(((.((((((((.....((.....((.....((..(((((..(.....)..))))))).....))...))......))))))...(((((((((.(......))))))))))....))))))))))))..))..((((..(.((.....)).)..))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.....A.(((((..((...((.........))...))......(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((........}..]]].]]]]]..............(...)........)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((..(((((((...((.....)).))))))....[[(((.((...(.....(((....)))...(.)....((.(((((((.......))))))))).......)....))...(((((........)))))]]((((.(((((...(((((((....)))))))..((((....)))...(...((((((...((((((((((((((((((((((...{{{...)))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).))).))).....((......)).)))).((((.....))))..)))....(((......(.(((...((..(....(.......(((((....(.[..).....)))))((.(((((((((((.......................)))))..)))))).))(...).......(((((((((.>.(...........)...(((((((....((((.....))))......))))))).].(.(.(((..((((((.(...(......(((......)))......).)))))..)))))(.(.(.........).).)........((..........(((((.......)))))..)..)....).)....)).))))))).)..)))...))).)...)))))....)).[..((.((.....>].)).)).....((((..(((.((......((((.(((((...(((((.(((((((((.(((((((.((.((.(((..........(((((........................))))).)))))...)).)))))))...(((((.....((((..((.(((((......)))))))..............(((((((((((.....)))))))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(..((....((....{..))....)).)(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}.....)))..)))))).......(....(.((((.(...((.......))...).))))...)....)........((((.((((((..(.(.(.(((......))).)...).)..((.(.....).))......)))))..)...))).)......((((((....))).)))...b.))..))).))))......(.((.(.(..(((..(.(((((......(....).....))))).)(((.....((((....((.(((((((}}}.)))))..)).))...))))....))).((((...((((.....a.......))))...))))..)))...).).)).).....(((((((.((..((((.(..(((........(((((.((((....)))).))))).......)))...(((..((((....((((.(((((((......)))))))))))...))))..)))...........)..))))..)))))))))(((((....(.......).......((.(((((((.((.....(.((.(..(((((......)))))..))).)....))....)))).))).))..))))).. mRNA decoding in human is kinetically and structurally distinct from bacteria (GA state 2); 28S rRNA 8g6j L7 120 2.8 RF00001 URS000002B0D5_9606 37020024 0003735 0005840 9606 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. mRNA decoding in human is kinetically and structurally distinct from bacteria (GA state 2); 5S rRNA 8g6j mR 11 2.8 37020024 9606 cguauguucaa ........... ........... mRNA decoding in human is kinetically and structurally distinct from bacteria (GA state 2); mRNA 8g6j At 76 2.8 RF00005 URS00005AA258_9606 37020024 0030533 0006412 9606 gcccgganagcucagncggnagagcaggggauugaanauccccgunuccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>><<<<<<<.....>>>>>>.>...<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..))))(((((.........)))).)...(((((..]....)))))))))))).... mRNA decoding in human is kinetically and structurally distinct from bacteria (GA state 2); A-site tRNA 8g6j Pt 77 2.8 RF00005 URS000057545F_9606 37020024 0030533 0006412 9606 cgcggggnggagcagcccggnagcucgucgggnucauaacccgaagnucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... mRNA decoding in human is kinetically and structurally distinct from bacteria (GA state 2); P-site tRNA 8g6r I 20 3.3 URS00026813C6_32630 36993498 32630 aagaagcuauuaaaaucaca .................... .................... Porcine epidemic diarrhea virus core polymerase complex; RNA (5'-R(P*AP*AP*GP*AP*AP*GP*CP*UP*AP*UP*UP*AP*AP*AP*AP*UP*CP*AP*CP*A)-3') 8g6r J 20 3.3 URS00026813C2_32630 36993498 32630 gguugugauuuuaauagcuu .................... .................... Porcine epidemic diarrhea virus core polymerase complex; RNA (5'-R(P*GP*GP*UP*UP*GP*UP*GP*AP*UP*UP*UP*UP*AP*AP*UP*AP*GP*CP*UP*U)-3') 8g6w A 1519 2.02 RF00177,RF01959,RF02542,RF01960 URS00000ABFE9_562 37396857 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugccggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<...<<<<<<<<<......>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<.>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<.......<<<....>>>......>>>>..<<.<<<<<......<<<<<<<<<<.......>>>>>>>>.>>.......>>>>>....>>.<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<..>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((.((......)).))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((.)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((.......(((....)))......))))..((.(((((...(...((((.((((.......)))).))).)...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(.(((((.((((((((((......((((((.....))))))....))))))))..))))))).)..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((((())))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..((..(((....)))..))...(......)..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....(((..(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)...))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Structure of WT E.coli 70S ribosome complexed with mRNA, P-site fMet-NH-tRNAfMet and A-site ortho-aminobenzoic acid charged NH-tRNAPhe; 16S rRNA 8g6w X 15 2.02 37396857 562 aaaauguucuaacua ............... ............... Structure of WT E.coli 70S ribosome complexed with mRNA, P-site fMet-NH-tRNAfMet and A-site ortho-aminobenzoic acid charged NH-tRNAPhe; mRNA 8g6w Y 74 2.02 RF00005 URS00005AA258_562 37396857 0030533 0006412 562 gcccggauagcucaggguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<...<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>.>>>>>>.... ((((((...(((........))).(((((.......))))).....((.((.......)).)).)))))).... Structure of WT E.coli 70S ribosome complexed with mRNA, P-site fMet-NH-tRNAfMet and A-site ortho-aminobenzoic acid charged NH-tRNAPhe; A-site oABZ-tRNAPhe 8g6w Z 75 2.02 RF00005 URS00026813D0_562 37396857 0030533 0006412 562 gcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacc <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>.... ((((((..((((......[..)))).(((((.......))))).....(.(((..]....))).))))))).... Structure of WT E.coli 70S ribosome complexed with mRNA, P-site fMet-NH-tRNAfMet and A-site ortho-aminobenzoic acid charged NH-tRNAPhe; P-site fMet-tRNAfMet 8g6w a 2753 2.02 RF02541 URS00004B0F34_562 37396857 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagcgucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcgcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<..>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<..>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<<.<<....>>..>>>>>>.>......>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<..>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>.(<<...<<<<<<<...<<<<<<.......>>>>>>.....<<)..(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((.(((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))))))).)))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((..(((.....)))...))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(())...)))..))))).))...........]]].)...))))))))))...)))))))((((.(((()))).))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((())))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).).....((.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..))....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Structure of WT E.coli 70S ribosome complexed with mRNA, P-site fMet-NH-tRNAfMet and A-site ortho-aminobenzoic acid charged NH-tRNAPhe; 23S rRNA 8g6w b 119 2.02 RF00001 URS0000049E57_562 37396857 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>> ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))) Structure of WT E.coli 70S ribosome complexed with mRNA, P-site fMet-NH-tRNAfMet and A-site ortho-aminobenzoic acid charged NH-tRNAPhe; 5S rRNA 8g6x a 2753 2.31 RF02541 URS00004B0F34_562 37396857 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagcgucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcgcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<..>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<..>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<<.<<....>>..>>>>>>.>......>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<..>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((.(((.(((...(((((......)))))[[(...).(((.....]])))...)))...))).)))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((.((((.....))))..))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(())...)))..))))).))...........]]].)...))))))))))...)))))))((((.(((()))).))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((())))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Structure of WT E.coli ribosome 50S subunit with complexed with mRNA, P-site fMet-NH-tRNAfMet and A-site meta-aminobenzoic acid charged NH-tRNAPhe; 23S rRNA 8g6x b 119 2.31 RF00001 URS0000049E57_562 37396857 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>> ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))) Structure of WT E.coli ribosome 50S subunit with complexed with mRNA, P-site fMet-NH-tRNAfMet and A-site meta-aminobenzoic acid charged NH-tRNAPhe; 5S rRNA 8g6x Y 74 2.31 RF00005 URS00005AA258_562 37396857 0030533 0006412 562 gcccggauagcucaggguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<...<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>.>>>>>>.... ((((((...((((......)))).((((.........)))).....((.((.......)).)).)))))).... Structure of WT E.coli ribosome 50S subunit with complexed with mRNA, P-site fMet-NH-tRNAfMet and A-site meta-aminobenzoic acid charged NH-tRNAPhe; A-site tRNA Phe 8g6x Z 75 2.31 RF00005 URS00026813D0_562 37396857 0030533 0006412 562 gcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacc <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>.... ((((((..((((......[..)))).(((((.......))))).....(((((..]....))))))))))).... Structure of WT E.coli ribosome 50S subunit with complexed with mRNA, P-site fMet-NH-tRNAfMet and A-site meta-aminobenzoic acid charged NH-tRNAPhe; P-site tRNA fMet 8g6x X 15 2.31 37396857 562 aaaauguucuaacua ............... ............... Structure of WT E.coli ribosome 50S subunit with complexed with mRNA, P-site fMet-NH-tRNAfMet and A-site meta-aminobenzoic acid charged NH-tRNAPhe; mRNA 8g6y X 15 2.09 37396857 562 aaaauguucuaacua ............... ............... Structure of WT E.coli ribosome 50S subunit with complexed with mRNA, P-site fMet-NH-tRNAfMet and A-site 3-aminopyridine-4-carboxylic acid charged NH-tRNAPhe; mRNA 8g6y Y 74 2.09 RF00005 URS00005AA258_562 37396857 0030533 0006412 562 gcccggauagcucaggguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<...<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>.>>>>>>.... ((((((...((((......)))).((((.........)))).....((.((.......)).)).)))))).... Structure of WT E.coli ribosome 50S subunit with complexed with mRNA, P-site fMet-NH-tRNAfMet and A-site 3-aminopyridine-4-carboxylic acid charged NH-tRNAPhe; A-site tRNA Phe 8g6y Z 75 2.09 RF00005 URS00026813D0_562 37396857 0030533 0006412 562 gcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacc <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>.... ((((((..((((......[..)))).(((((.......))))).....(((((..]....))))))))))).... Structure of WT E.coli ribosome 50S subunit with complexed with mRNA, P-site fMet-NH-tRNAfMet and A-site 3-aminopyridine-4-carboxylic acid charged NH-tRNAPhe; P-site tRNA fMet 8g6y a 2753 2.09 RF02541 URS00004B0F34_562 37396857 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagcgucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcgcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<..>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<..>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<<.<<....>>..>>>>>>.>......>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<..>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((.(((.....))).).))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(())...)))..))))).))...........]]].)...))))))))))...)))))))((((((((()))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((())))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).).....((.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..))....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Structure of WT E.coli ribosome 50S subunit with complexed with mRNA, P-site fMet-NH-tRNAfMet and A-site 3-aminopyridine-4-carboxylic acid charged NH-tRNAPhe; 23S rRNA 8g6y b 119 2.09 RF00001 URS0000049E57_562 37396857 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>> ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))) Structure of WT E.coli ribosome 50S subunit with complexed with mRNA, P-site fMet-NH-tRNAfMet and A-site 3-aminopyridine-4-carboxylic acid charged NH-tRNAPhe; 5S rRNA 8g7p a 1529 2.9 RF00177,RF01959,RF02542,RF01960 38538914 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugccggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<..........>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<.......<<<<..>>>>......>>>>...<.<<<<<......<.<<<<<<<<.<...>.>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<..>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>.............>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((.(((..........)))..)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(..(.((((((((.......)))))))).)...)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((((())))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...((.(((....))).)).....(.....)..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Structure of the Escherichia coli 70S ribosome in complex with EF-Tu and Ile-tRNAIle(LAU) bound to the cognate AUA codon (Structure I); 16S Ribosomal RNA 8g7p w 76 2.9 RF00005 38538914 0030533 562 ggccccunagcucagungnnagagcaggcgacunaunaucgcuugnncgcuggnucaaguccagcaggggccacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((....[...)))).((((.........)))).....(((((..]....)))))))))))).... Structure of the Escherichia coli 70S ribosome in complex with EF-Tu and Ile-tRNAIle(LAU) bound to the cognate AUA codon (Structure I); Isoleucine tRNA 8g7p x 76 2.9 RF00005 38538914 0030533 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Structure of the Escherichia coli 70S ribosome in complex with EF-Tu and Ile-tRNAIle(LAU) bound to the cognate AUA codon (Structure I); P-site initiator tRNA 8g7p y 76 2.9 RF00005 38538914 0030533 562 ggccccunagcucagungnnagagcaggcgacunaunaucgcuugnncgcuggnucaaguccagcaggggccacca <<<<<<<..<<<<........>>>><<<<<<.......>>>>>>....<<<<<.......>>>>>>>>>>>>.... (((((((....((........)).((((((.........))))))...(((.(........))))))))))).... Structure of the Escherichia coli 70S ribosome in complex with EF-Tu and Ile-tRNAIle(LAU) bound to the cognate AUA codon (Structure I); Isoleucine tRNA 8g7p v 13 2.9 38538914 2681598 aaaaugauaaaag ............. ............. Structure of the Escherichia coli 70S ribosome in complex with EF-Tu and Ile-tRNAIle(LAU) bound to the cognate AUA codon (Structure I); M-I mRNA 8g7p A 2899 2.9 RF02541 38538914 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcgcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<...<<<<<........>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<.....<<.......>>.....>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<..>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<<.<<....>>..>>>>>>.>.....>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<...<<<...........<<<<....<<......<<<<<<<<....>>>>>>>>...>>..............>>>>..>>>...>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......((((((((((.((.(((...(((((......)))))[[(...).(((.....]])))...)))...)).))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((........)))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((.(((.....))).).))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(.......................).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((((()))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((.((.(.(.(...........((..(...(.........(..(((....)))..)......)......(..)...)..))..).)..))).)))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Structure of the Escherichia coli 70S ribosome in complex with EF-Tu and Ile-tRNAIle(LAU) bound to the cognate AUA codon (Structure I); 23S Ribosomal RNA 8g7p B 120 2.9 RF00001 URS00005C6868_562 38538914 0003735 0005840 562 ugccuggcggcaguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Structure of the Escherichia coli 70S ribosome in complex with EF-Tu and Ile-tRNAIle(LAU) bound to the cognate AUA codon (Structure I); 5S Ribosomal RNA 8g7q a 1529 3.1 RF00177,RF01959,RF02542,RF01960 38538914 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugccggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<.<<<<........>>>>..>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<..>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<..<.<<<<<<<........>>>>>>>>...>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((.(((..........)))..)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((.(....).))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(..(.((((((((.......)))))))).)...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((((())))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))....(.....)..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Structure of the Escherichia coli 70S ribosome in complex with EF-Tu and Ile-tRNAIle(LAU) bound to the near-cognate AUG codon (Structure II); 16S Ribosomal RNA 8g7q w 76 3.1 RF00005 38538914 0030533 562 ggccccunagcucagungnnagagcaggcgacunaunaucgcuugnncgcuggnucaaguccagcaggggccacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((....[...)))).((((.........)))).....(((((..]....)))))))))))).... Structure of the Escherichia coli 70S ribosome in complex with EF-Tu and Ile-tRNAIle(LAU) bound to the near-cognate AUG codon (Structure II); Isoleucine tRNA 8g7q x 76 3.1 RF00005 38538914 0030533 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Structure of the Escherichia coli 70S ribosome in complex with EF-Tu and Ile-tRNAIle(LAU) bound to the near-cognate AUG codon (Structure II); P-site initiator tRNA 8g7q y 76 3.1 RF00005 38538914 0030533 562 ggccccunagcucagungnnagagcaggcgacunaunaucgcuugnncgcuggnucaaguccagcaggggccacca <<<<<.<..<<<<........>>>><<<<<<.......>>>>>>......<<<.......>>>..>.>>>>>.... (((((((..((((....[...))))(((((.........)))))....(.(((..]....))).)))))))).... Structure of the Escherichia coli 70S ribosome in complex with EF-Tu and Ile-tRNAIle(LAU) bound to the near-cognate AUG codon (Structure II); Isoleucine tRNA 8g7q v 11 3.1 38538914 2681598 aaaaugaugaa ........... ........... Structure of the Escherichia coli 70S ribosome in complex with EF-Tu and Ile-tRNAIle(LAU) bound to the near-cognate AUG codon (Structure II); M-M mRNA 8g7q A 2899 3.1 RF02541 38538914 0003735 0005840 562 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<<<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<........>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<.<<.......>>.>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<..>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<....<<..>>.....>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<<.<<....>>..>>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<.............<<<<<<<....>>>>>>>....................>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((..((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))))))..)))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((........)))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((..(((.....)))...))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.((.....................)).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((((()))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((.(.(.((((...........(((.(...(.........(...((....))...)......)......(..)...).)))..)))).).).)))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Structure of the Escherichia coli 70S ribosome in complex with EF-Tu and Ile-tRNAIle(LAU) bound to the near-cognate AUG codon (Structure II); 23S Ribosomal RNA 8g7q B 120 3.1 RF00001 URS00005C6868_562 38538914 0003735 0005840 562 ugccuggcggcaguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Structure of the Escherichia coli 70S ribosome in complex with EF-Tu and Ile-tRNAIle(LAU) bound to the near-cognate AUG codon (Structure II); 5S Ribosomal RNA 8g7r a 1528 2.8 RF00177,RF01959,RF02542,RF01960 URS00000ABFE9_562 38538914 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugccggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<.<<<<........>>>>..>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<..>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>....<....>...>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((.(((..........)))..)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(...((((.((((.......)))).))).)...)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((((())))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((.(((....))).)))....(.....)..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Structure of the Escherichia coli 70S ribosome in complex with A-site tRNAIle(LAU) bound to the cognate AUA codon (Structure III); 16S Ribosomal RNA 8g7r w 76 2.8 RF00005 38538914 0030533 562 ggccccunagcucagungnnagagcaggcgacunaunaucgcuugnncgcuggnucaaguccagcaggggccacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((....[...)))).((((.........)))).....(((((..]....)))))))))))).... Structure of the Escherichia coli 70S ribosome in complex with A-site tRNAIle(LAU) bound to the cognate AUA codon (Structure III); Isoleucine tRNA 8g7r x 76 2.8 RF00005 38538914 0030533 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Structure of the Escherichia coli 70S ribosome in complex with A-site tRNAIle(LAU) bound to the cognate AUA codon (Structure III); P-site initiator tRNA 8g7r y 76 2.8 RF00005 38538914 0030533 562 ggccccunagcucagungnnagagcaggcgacunaunaucgcuugnncgcuggnucaaguccagcaggggccacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((....[...))))(((((.........)))))....(((((..]....)))))))))))).... Structure of the Escherichia coli 70S ribosome in complex with A-site tRNAIle(LAU) bound to the cognate AUA codon (Structure III); Isoleucine tRNA 8g7r v 11 2.8 38538914 2681598 aaaaugauaaa ........... ........... Structure of the Escherichia coli 70S ribosome in complex with A-site tRNAIle(LAU) bound to the cognate AUA codon (Structure III); M-I mRNA 8g7r A 2899 2.8 RF02541 38538914 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcgcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<........>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<.....................>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<..>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.......<<<<<<.<<....>>..>>>>>>.......>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<..<<<<...........<<<<<...<<......<<<<.<<<....>>>.>>>>...>>.............>>>>>..>>>>..>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......((((.(((((.((.(((...(((((......)))))[[(...).(((.....]])))...)))...)).))))).))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((........)))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((..(((.....)))...))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((..(.....................)......(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((((()))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((..(.(.(...........(..((...((.......((..(((....)))..))....)).............))..)..).)..).)))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..)))))).......(((..(.((((((...((.......))...))))))...).)).)........(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Structure of the Escherichia coli 70S ribosome in complex with A-site tRNAIle(LAU) bound to the cognate AUA codon (Structure III); 23S Ribosomal RNA 8g7r B 120 2.8 RF00001 URS00005C6868_562 38538914 0003735 0005840 562 ugccuggcggcaguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Structure of the Escherichia coli 70S ribosome in complex with A-site tRNAIle(LAU) bound to the cognate AUA codon (Structure III); 5S Ribosomal RNA 8g7s a 1528 3.1 RF00177,RF01959,RF02542,RF01960 URS00000ABFE9_562 38538914 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugccggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<......>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>..<<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>>.<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<..>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>.............>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((.(((..........)))..)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(..(.((((((((.......)))))))).)...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((.(((((((()))))))).)))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...((.(((....))).)).....(.....)..))))).))).((.((....((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...))..))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Structure of the Escherichia coli 70S ribosome in complex with P-site tRNAIle(LAU) bound to the cognate AUA codon (Structure IV); 16S Ribosomal RNA 8g7s x 76 3.1 RF00005 38538914 0030533 562 ggccccunagcucagungnnagagcaggcgacunaunaucgcuugnncgcuggnucaaguccagcaggggccacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... ((.((((..((((....[...)))).((((.........)))).....(((((..]....)))))))).))).... Structure of the Escherichia coli 70S ribosome in complex with P-site tRNAIle(LAU) bound to the cognate AUA codon (Structure IV); Isoleucine tRNA 8g7s y 76 3.1 RF00005 38538914 0030533 562 ggccccunagcucagungnnagagcaggcgacunaunaucgcuugnncgcuggnucaaguccagcaggggccacca <<<<<<...<<<<........>>>>.<<<<<.......>>>>>.....<<<<.........>>>>.>>>>>>.... ((((((...((((....[...))))..(((.........)))......(((.(..].....)))).)))))).... Structure of the Escherichia coli 70S ribosome in complex with P-site tRNAIle(LAU) bound to the cognate AUA codon (Structure IV); Isoleucine tRNA 8g7s A 2899 3.1 RF02541 38538914 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcgcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<<..>>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<.....................>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<..>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.......<<<<<<.<<....>>..>>>>>>.......>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<....<<......<<<<..<<....>>..>>>>...>>..............>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......((((((((((.((.(((...(((((......)))))[[(...).(((.....]])))...)))...)).))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((........)))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((..(((.....)))...))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..((.(....{.(((((.(((...................))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((((()))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...(((.((((((((.((.....))))))))))...)))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((.(.(.((((.(.........((..(...(.........(...((....))...)......).............)..))).)))).).).)))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Structure of the Escherichia coli 70S ribosome in complex with P-site tRNAIle(LAU) bound to the cognate AUA codon (Structure IV); 23S Ribosomal RNA 8g7s B 120 3.1 RF00001 URS00005C6868_562 38538914 0003735 0005840 562 ugccuggcggcaguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Structure of the Escherichia coli 70S ribosome in complex with P-site tRNAIle(LAU) bound to the cognate AUA codon (Structure IV); 5S Ribosomal RNA 8g7t X 24 3.2 URS0002617748_9606 37951994 9606 ngacguacguuucgcgacuguaga ........................ ........................ Cryo-EM structure of Riplet:RIG-I:dsRNA complex (end-end); p3dsRNA24a 8g7t Y 24 3.2 URS00029156E3_9606 37951994 9606 ncuacagucgcgaaacguacgucc ........................ ........................ Cryo-EM structure of Riplet:RIG-I:dsRNA complex (end-end); p3dsRNA24b 8g7u X 24 4.0 URS0002617748_9606 37951994 9606 ngacguacguuucgcgacuguaga ........................ ........................ Cryo-EM structure of Riplet:RIG-I:dsRNA complex (end-semi-closed end); p3dsRNA24a 8g7u Y 24 4.0 URS00029156E3_9606 37951994 9606 ncuacagucgcgaaacguacgucc ........................ ........................ Cryo-EM structure of Riplet:RIG-I:dsRNA complex (end-semi-closed end); p3dsRNA24b 8g7v X 23 3.9 URS0002617748_9606 37951994 9606 ngacguacguuucgcgacuguag ....................... ....................... Cryo-EM structure of Riplet:RIG-I:dsRNA complex (end-inter); p3dsRNA24a 8g7v Y 23 3.9 URS00029156E3_9606 37951994 9606 cuacagucgcgaaacguacgucc ....................... ....................... Cryo-EM structure of Riplet:RIG-I:dsRNA complex (end-inter); p3dsRNA24b 8glp S2 1672 1.67 RF01960,RF02542,RF01959,RF00177 URS00026813DB_9606 37020024 0003735 0005840 9606 uaccugguugauccugccaguagcaunugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucnuuaaaucaguuauggunccuunggucgcucgccacuuggauaacugugguanuucuagngcuaananaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgccccccguggcggcgacgacccauucgaacgucngcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgaunccggaganggagccugagaaacggcuaccacauncaaggnaggcagcaggcgcgcnaauuacccacucccgacccggggangungugangaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaanuccuuuaacgaggnuccauuggagngcaagucuggugccagcagccgcggnaauuccagcuccaauancguauauuaaaguugcugcaguunaaaagcucguaguungaucuuuuuacuuugaaaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaaungaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagancgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacncaacacgggaaaccucacccggcccggacacggacagganugacagauugauagcucuuucucgauuccguggguggngnugcauggcnguucuuaguugguggagcgauuugucugguuaauuccgauaacgancgagacunuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuncuuanagggacaaguggcguucagccacccgagauugagcaauaacangucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgagnaauucccaguaagugcgggucauaagcuugcguugauunagucccugcccuuuguacacaccgnccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggcggagcgcugagaagacggucgaacungacuaucuagaggaaguaaaagucguancaagguuucnguaggugnnccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<....<<....<<<<<..........<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<<<....>>>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<<......>>>>>>>>.>>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....<<<<<<<<<.<<<....>.>>.>>>>>.>>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<.....<<<<<<.<.......<<...<.......>.<<<<.......>>>>...>>......>.>>>..>>>........<.<<.<<<<<<<...............>>>>>>>.>>.>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<<....>>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<........<<........>>..........<<<<<.<....<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<.......>>>>.>>>>.....>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.....>.>>>>>......>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>............<<<<<..........>>>>>...........>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<.<<<<..>>>>...>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))((...(((((......(..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..((....((((....((.....((.....((.(((.....))).))......))......)).((((...(((((......)))))...))))((..(((((...(......)..)))))......)).(.((((..((((...).))).))))).).)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)........(((((((((..((....))...))))).))))....(.((..(...........)..))......)..((((([[....(.(.((.....((..]])).......)).)))))))..)))))...))..[......(.([[...(.(.((...(.(..(.....(..(((.(........(..((.......)).(((.......)))....).......).)))....)........(.((.(((((((...............))))))).)).)....)....(((..(...(...(((...(((.((((((((...(..........)......)))))))).))).......((....))....)))..)...)...))..)).)...)).)....((((((....(...((((.........))))...).))))))......{...(((.((..((..(.((((((.(((((....))))))))))).)..))....((..]]))...))...].))))).).(((......((.(....).))....)))...]]].]((((..(((((((..((..((.((..(((..(((((.......(........)...........(((((.(....(((((........((.(((........))).))......)))))...((.(((...(.((((((....((..(((((....)))..(.((......)))...))..))....(((...(...((.(..(((((((((((((....).)))).)))).....))))..).))..).....(((((.....)))))........)))....))).))).....).))))).....).)))))...)).)))..))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....((((............)))).....)..)..)).)).....((((((((.......))))))))......))...))))))).)).))..(.(..((.(..((((.((..(.((((((((.(((..((((.((...(((((..(((())))....)))))...)).))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}........ mRNA decoding in human is kinetically and structurally distinct from bacteria (Consensus LSU focused refined structure); 18S rRNA 8glp L8 156 1.67 RF00002,RF02540 URS00004B2C76_9606 37020024 0003735 0005840 9606 cgacucuuagcggnggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauuncaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<<<<....>>>>.....<.<<<......>>.............>>>..>...>>>....<<....>><<<<<<<<<.....>>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))(((((((((.....))))))))).................... mRNA decoding in human is kinetically and structurally distinct from bacteria (Consensus LSU focused refined structure); 5.8S rRNA 8glp L5 3546 1.67 RF02543 URS00026813F0_9606 37020024 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagngngaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcgcggcggaucuuucccggcgggggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucgggggcccccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcgcucuccccccugggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccggggggccacgcgcgcgucccccgaagagggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccnucuugnaacncggaccaaggagunuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccnanagauggugancuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauagnggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcagacccgagccacgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcngaacuggcgnugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggaaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaunuuggugguagunnnaaauauucaaacgagaacuuugaaggccgaaguggngaaggguuccaugngaacagnanuugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggagcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccnuauccgcagcaggucuncaaggugaacngccucuggnauguuggaacaanguagguaagggaagucggcaagcnggauccguaacuucnggauaaggauuggcucuaagggcugguagcagccgacuuagaacuggugcggaccaggngaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugccnagugcucugaaugucanagugnngaaauucaaugaagcgcggnuaaacggcgggaguancuaugacucucuuaagguagcnaanugccucnucaucuaauuagugangcgcaugaanggaugancgagnuucccacugunccuaccuacuauccagcgaaaccacngncaagggaacgggcuuggnggaaucagcggngaaagaagacccuguugagcuugacncuagucuggcacggugaanagacguuuuuucacugacccggugaggcgggggggcgagccccgaggggcucucgcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacugnggcgguacaccugucaaacgguancgcaggnnuccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucagnacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggangugucagaaaaguuaccacagngauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuungaugucggnucuuccuaucauugugaagcagaauucaccaagcguungaunnuucacccacuaauagggaacgugngcugggnuuagancgucgugagacagguuaguuuuacccuacugaugnuguguuguugccaugguanuccugcucaguacgagaggaaccgcagnuncanacauuugguguaunugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccggucccccgcgggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>>..<<<<<<<<<<...<<<<<<<<.<<.....<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>.>>>>>>>>>>..>>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<<<..<<<<<<<...<<<...<<<<<.<<<..<<<...>>>>>>>>>>>..>>>..>>>>...>>>>>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<.<<<<<<<<<<<<<<<...<<..<<<..<.<<<<......<<<<<<<<..>>>>>>>>.......>>>>.>.>>>........>>>>>>..>>>>>>>>>>>....................<<<<<<.<<<<<<..>>>>>>.<<<<<<.<<<<.<<<<<<<<<<<<<<<<<<<<<<<<.<<<<....>>>>.>>>>>>>>>>>.>>>>>>>>>>.>>>...>>>>>>>>.>>..<<<<<<<<<<.....>>>>>>>>.>>....>>>>>>......>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<<<<...<<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<<....>>>>>>>>..<<<<<...<<<..<<<..((((.(((.>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>>.<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<.................<<<.<<<<<<<<<...<<<....<<<..<.<<<..<<<<<<.<<...>>.>>>>>>>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.........>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<..>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<...........))).))))...............>>>>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<<<<<...>>>>>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<.<<<<<..<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<...............>>>>><<.<<<<<<<<<<<....>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<.<<..>>.>>>>>>...<<<<<.....<<<<..<<.<<<.<......>.>>>>>..............<<<<<<<<<<<.....>>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>><<<<....>>>>>>)))].....<<<<<<<..<<<..)))))).>>>>>>>>>>.........>>>>..>>>>>>.......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<]]].>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.....<<<<<<<.<<..<<<<....<<<........<<<<<.<<<<...>>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>..............>>>>..>>>>>>>>><<<<<....................<<.<<<<<<<.<<.....<<<<.<..<<<<..>>>>..>>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..(((((((((((.....)))))).))))....))))....((((((((((...(((((.((.((.(...((((((((..({((((......)))))....[[(...).(((....}]])))...).)))))))))))).)))))..))))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....(((((((((((..((((((....(((.(.(((((.(((..(((...)))))))))))).)))...)))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((..(.((((......((((((((())))))))).......)))).).)))........))))))..)))))))))))....................((((((.((((((())))))).((((((.((((.(((((((((((((((((.((((((.((((....)))).)))))).)))).)))))))))).)))...)))))))).))..((((((((((.....)))))))).))..[.)))))).....))).)))))...)))))...)))))))).<((((........))))((((((....(((((((((((((..(((..(((((........))))..)..)))...((....))...((((((((....))))))))..(((((...(((..(((..[[[[.[[[.)))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((.................(((.((((((((.....((.....((.....((..((((((.((...)).)))))))).....))...))......))))))...(((((((((.(......))))))))))....))))))))))))..))..((((..(.((.....)).)..))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.....{..((((..))))....)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((...........]]].]]]]].(...)........)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((..(((((((...((.....)).))))))....[[(((.((...(.....(((....)))...(.)....((.((((.((((...)))).)))))).......)....))...(((((........)))))]]((((.(((((...(((((((....)))))))..((((....)))...(...((((((...((((((((((((((((((((((...{{{...)))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).))).))).....((......)).)))).((((.....))))..)))....(((......(.(((...((..(....(.......(((((....(.[..).....)))))((.(((((((((((....)))))..)))))).))(...).......(((((((((.>.(...........)...(((((((....((((.....))))......))))))).].(.(.(((..((((((.(..((......(((......)))......)))))))..)))))(.(.(.........).).)........((..........(((((.......)))))..)..)....).)....)).))))))).)..)))...))).)...)))))....)).[..((.((.....>].)).)).....((((..(((.((......((((.(((((...(((((.(((((((((.((((((.((..)).))))))...(((((.....((((..((.((.(........).))))..............(((((((((((.....)))))))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(..((....((....{..))....)).)(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}.....)))..)))))).......(....(.((((.(...((.......))...).))))...)....)........((((.((((((..(.(.(.(((......))).)...).)..((.(.....).))......)))))..)...))).)......((((((....))).)))...a.))..))).))))......(.((.(.(..(((..(.(((((......(....).....))))).)(((.....((((....((.(((((((}}}.)))))..)).))...))))....))).((((...((((.....}.......))))...))))..)))...).).)).).....(((((((.((..((((.(..(((........(((((.((((...)))).))))).......)))...(((..((((....((((.(((((((......)))))))))))...))))..)))...........)..))))..)))))))))(((((....(.......).......((.(((((((.((.....(.((.(..((((()))))..))).)....))....)))).))).))..))))).. mRNA decoding in human is kinetically and structurally distinct from bacteria (Consensus LSU focused refined structure); 28S rRNA 8glp L7 120 1.67 RF00001 URS000002B0D5_9606 37020024 0003735 0005840 9606 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. mRNA decoding in human is kinetically and structurally distinct from bacteria (Consensus LSU focused refined structure); 5S rRNA 8glp Pt 77 1.67 RF00005 URS000057545F_9606 37020024 0030533 0006412 9606 cgcggggnggagcagcccggnagcucgucgggnucauaacccgaagnucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... mRNA decoding in human is kinetically and structurally distinct from bacteria (Consensus LSU focused refined structure); P-site tRNA 8gna C 32 2.8 URS0002681375_237368 36484100 237368 acuuaaugucacgguacccaauuuucugcccc ................................ ................................ Structure of the SbCas7-11-crRNA-NTR complex; RNA (32-MER) 8gna J 17 2.8 URS000268136A_237368 36484100 237368 ggggcagaaaauugggu ................. ................. Structure of the SbCas7-11-crRNA-NTR complex; RNA (5'-R(P*GP*GP*GP*GP*CP*AP*GP*AP*AP*AP*AP*UP*UP*GP*GP*GP*U)-3') 8gs2 R 38 2.84 URS000261777A_45657 36423304 45657 uugaugucacggaaccuuuguugucuucgacaugggua ...................................... ...................................... Structure of the Cas7-11-Csx29-guide RNA-target RNA (non-matching PFS) complex; crRNA 8gs2 D 23 2.84 URS0002617781_45657 36423304 45657 uacccaugucgaagacaacaaag ....................... ....................... Structure of the Cas7-11-Csx29-guide RNA-target RNA (non-matching PFS) complex; target RNA with non-matching PFS 8gu6 C 33 3.1 URS0002617783_237368 36484100 237368 gacuuaaugucacgguacccaauuuucugcccc ................................. ................................. Structure of the SbCas7-11-crRNA-NTR-Csx29 complex; RNA (33-MER) 8gu6 J 17 3.1 URS0002681381_237368 36484100 237368 ggggcagaaaauugggu ................. ................. Structure of the SbCas7-11-crRNA-NTR-Csx29 complex; RNA (5'-R(P*GP*GP*GP*GP*CP*AP*GP*AP*AP*AP*AP*UP*UP*GP*GP*GP*U)-3') 8gw1 I 25 3.31 URS00021ED98C_2697049 36335936 2697049 gcgguaguagcaugcuagggagcag ......................... ......................... A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analogue inhibitors; RNA (25-MER) 8gw1 J 26 3.31 URS00029156AF_2697049 36335936 2697049 agcugcucccuagcaugcuacuaccg .......................... .......................... A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analogue inhibitors; Template 8gwb I 25 2.75 URS00021ED98C_2697049 36335936 2697049 gcgguaguagcaugcuagggagcag ......................... ......................... SARS-CoV-2 E-RTC complex with RNA-nsp9; primer 8gwb J 27 2.75 URS0002311969_2697049 36335936 2697049 ugacugcucccuagcaugcuacuaccg ........................... ........................... SARS-CoV-2 E-RTC complex with RNA-nsp9; template 8gwe I 25 2.66 URS00021ED98C_2697049 36335936 2697049 gcgguaguagcaugcuagggagcag ......................... ......................... SARS-CoV-2 E-RTC complex with RNA-nsp9 and GMPPNP; primer 8gwe J 27 2.66 URS00023119E5_2697049 36335936 2697049 ugacugcucccuagcaugcuacuaccg ........................... ........................... SARS-CoV-2 E-RTC complex with RNA-nsp9 and GMPPNP; template 8gwf I 25 3.39 URS00021ED98C_2697049 36335936 2697049 gcgguaguagcaugcuagggagcag ......................... ......................... A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analogue inhibitors; primer 8gwf J 27 3.39 URS0002311969_2697049 36335936 2697049 ugacugcucccuagcaugcuacuaccg ........................... ........................... A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analogue inhibitors; template 8gwg I 25 3.37 URS00021ED98C_2697049 36335936 2697049 gcgguaguagcaugcuagggagcag ......................... ......................... A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analogue inhibitors; primer 8gwg J 27 3.37 URS0002311969_2697049 36335936 2697049 ugacugcucccuagcaugcuacuaccg ........................... ........................... A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analogue inhibitors; Template 8gwi I 25 3.18 URS00021ED98C_2697049 36335936 2697049 gcgguaguagcaugcuagggagcag ......................... ......................... A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analogue inhibitors; primer 8gwi J 27 3.18 URS0002311969_2697049 36335936 2697049 ugacugcucccuagcaugcuacuaccg ........................... ........................... A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analogue inhibitors; RNA (27-MER) 8gwk I 25 2.72 36335936 2697049 gcgguaguagcaugcuagggagcag ......................... ......................... SARS-CoV-2 RNA E-RTC complex with RMP-nsp9 and GMPPNP; primer 8gwk J 26 2.72 36335936 2697049 agcugcucccuagcaugcuacuaccg .......................... .......................... SARS-CoV-2 RNA E-RTC complex with RMP-nsp9 and GMPPNP; template 8gwm I 25 2.64 36335936 2697049 gcgguaguagcaugcuagggagcag ......................... ......................... SARS-CoV-2 E-RTC bound with MMP-nsp9 and GMPPNP; RNA (25-MER) 8gwm J 26 2.64 36335936 2697049 agcugcucccuagcaugcuacuaccg .......................... .......................... SARS-CoV-2 E-RTC bound with MMP-nsp9 and GMPPNP; RNA (26-MER) 8gwn I 25 3.38 URS00021ED98C_2697049 36335936 2697049 gcgguaguagcaugcuagggagcag ......................... ......................... A mechanism for SARS-CoV-2 RNA capping and its inhibitor of AT-527; primer 8gwn J 27 3.38 URS0002311969_2697049 36335936 2697049 ugacugcucccuagcaugcuacuaccg ........................... ........................... A mechanism for SARS-CoV-2 RNA capping and its inhibitor of AT-527; template 8gwo I 25 3.8 URS00021ED98C_32630 36335936 32630 gcgguaguagcaugcuagggagcag ......................... ......................... A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analogue inhibitors; RNA (25-MER) 8gwo J 27 3.8 URS0002311969_32630 36335936 32630 ugacugcucccuagcaugcuacuaccg ........................... ........................... A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analogue inhibitors; template 8gxb A 61 2.15 URS0002681379_1306 36610789 1306 ngagcguuacguccgaaagucgcauugcacuccgcgacacggcucuuuaaaaacaaaagga <<<<<..<...(((....<<<<<..........>>>>>..>>>>>>............))) ((((((.....[[[....(((((..........))))).).)))))............]]] Crystal structure of NAD+ -II riboswitch in complex with NAD+; NAD+ II riboswitch 8gxb B 61 2.15 URS0002681379_1306 36610789 1306 ngagcguuacguccgaaagucgcauugcacuccgcgacacggcucuuuaaaaacaaaagga <<<<<......(((....<<<<<..........>>>>>...>>>>>............))) ((((((.....[[[....(((((..........))))).).)))))............]]] Crystal structure of NAD+ -II riboswitch in complex with NAD+; NAD+ II riboswitch 8gxc A 61 2.5 URS0002681379_1306 36610789 1306 ngagcguuacguccgaaagucgcauugcacuccgcgacacggcucuuuaaaaacaaaagga <<<<<......(((....<<<<<..........>>>>>...>>>>>............))) ((((((.....[[[....(((((..........))))).).)))))............]]] Crystal structure of NAD+ -II riboswitch in complex with NMN; 61-mer RNA 8gxc B 61 2.5 URS0002681379_1306 36610789 1306 ngagcguuacguccgaaagucgcauugcacuccgcgacacggcucuuuaaaaacaaaagga <<<<<......(((....<<<<<..........>>>>>...>>>>>............))) ((((((.....[[[....(((((..........))))).).)))))............]]] Crystal structure of NAD+ -II riboswitch in complex with NMN; 61-mer RNA 8h2h A 692 3.2 RF00029 URS00021ED979_1358 36344519 0000373 1358 gugcgcccagauaggguguuaagucaaguaguuuaagguacuacucuguaagauaacacagaaaacagccaaccuaaccgaaaagcgaaagcugauacgggaacagagcacgguuggaaagcgaugaguuaccuaaagacaaucggguacgacugagucgcaauguuaaucagauauaagguauaaguuguguuuacugaacgcaaguuucuaauuucgguuaugugucgauagaggaaagugucugaaaccucuaguacaaagaaagguaaguuaugguuguggacuuaucuguuaucaccacauuuguacaaucuguaggagaaccuaugggaacgaaacgaaagcgaugccgagaaucugaauuuaccaagacuuaacacuaacuggggauacccuaaacaagaaugccuaaaggaggaaaaaggcuauagcacuagagcuugaaaaucuugcaaggguacggaguacucguaguagucugagaaggguaacgcccuuuacauggcaaagggguacaguuauuguguacuaaaauuaaaaauugauuagggaggaaaaccucaaaccaacaauggcaauuuuagacaauaacagagccguauacuccgagagggguacguacgguucccgaagaggguggugcaaaccagucacaguaaugugaacaaggcgguaccucccuacuucac ..[..<<<<<....<<<<<<<<<<<..<<<<<.......>>>>><<<<.....((((.>>>>.<<<<.<<<<<<...<...<<.<<....>>>..>..>.........]..>>>>>>...<<<<....<.......(((............>.....>>>>..>>>>...<<<<.....<<<<<.<<<.......>>>...<<<..<<.<........<.........>..............)))............<<<<<<...<<<<<<<<.........>>>>>>>>.))))......>.>>>>>........<<<......>>>.........>>>....>>>>>>>>.....>>>>..........>>>>>>>>>>>..>>>>>...<<<......<.......<....>..........<<<...<..>...>>>.........>.....>>.>.....<<<<<.............<<<<<.......>>>>>...........>>.>>>.<<<<<<<................<<.............................>>............>>>>>>>.<<<<<<<<<<<<<<....>>>>>..>>>>>>>>>..<<<<<<<<..<<<............<....>.............>>>..>>>>.>>>>.. .....(((((....(((((((((((..((((.........))))((((.....[.[[.)))).((((.((((((....(.....((....))......)............))))))...((((....(..(((.....[....)))....).....))))..))))...((((.....((....((.(......)))...(((...(..................................]................((..(...(.((((((.........)))))).).]].]......)...)).........(..........)..........).....)))...)).....))))..........)))))))))))..)))))(...((......(.(......(..)..........((..............)).......).)....))...)...(.................((((((.....))))))................).((((((..................(..........((.....))..........)..............))))))..(((((((((((((....)))))..))))))))...((((((((..(.((....(......(......).......)..))..).)))).)))).. Cryo-EM structure of a Group II Intron Complexed with its Reverse Transcriptase; LtrB 8h2h B 12 3.2 URS0000A76362_1358 36344519 1358 cacauccauaac ............ ............ Cryo-EM structure of a Group II Intron Complexed with its Reverse Transcriptase; RNA (5'-R(P*CP*AP*CP*AP*UP*CP*CP*AP*UP*AP*AP*C)-3') 8h69 3 18 3.7 URS0002681438_93838 37488357 93838 uaaacuccugcuuuugcu .................. .................. Cryo-EM structure of influenza RNA polymerase; RNA (5'-R(*UP*AP*AP*AP*CP*UP*CP*CP*UP*GP*CP*UP*UP*UP*UP*GP*CP*U)-3') 8h69 5 19 3.7 URS000268144C_93838 37488357 93838 aguagaaacaaggaguuuu .<<....>>.......... .((....)).......... Cryo-EM structure of influenza RNA polymerase; RNA (5'-R(P*AP*GP*UP*AP*GP*AP*AP*AP*CP*AP*AP*GP*GP*AP*GP*UP*UP*UP*U)-3') 8h6e A 59 3.2 38658629 9606 uuuccuugaagcuuucgugcugacccugucccuuuuuuuuccaccaggugaguauggau ........................................................... ........................................................... Cryo-EM structure of human exon-defined spliceosome in the late pre-B state.; pre-mRNA 8h6e 6A 59 3.2 RF00026 38658629 0030621 0000244,0000353 0005688,0046540 9606 acgauacagagaagauuagcauggccccugcgcaaggaugacauucgugaagcguauuu ........................................................... ........................................................... Cryo-EM structure of human exon-defined spliceosome in the late pre-B state.; U6 snRNA 8h6e 5A 114 3.2 RF00020 38658629 0000244,0000353 0005682,0046540 9606 cucugguuucucuucagaucgcauaaaucuuucgccuuuuacuaaagauuuccguggagaggaacaacucugagucuuaacccaauuuuuugaggccuugcuuuggcaaggcua <<<.<<<<<<<<<<<<........<<<<<<<<...........>>>>>>>>...>>>>>>>>>>>....>.>>>...................<<<<<<<<....>>>>>>>>. (((.((((((((((((...((...((((((((.(.......).)))))))).)))))))))))))....).)))....................(((((((....))))))).. Cryo-EM structure of human exon-defined spliceosome in the late pre-B state.; U5 snRNA 8h6e 4A 125 3.2 RF00015 38658629 0017070 0000244,0000353 0005687,0046540 9606 agcuuugcgcaguggcaguaucguagccaaugaggucuauccgaggcgcgauuugcuaauugaaaacuucccaauagccgugacgacuagucggcacuggcaauuuuugacagucucgagacugg ...................<<<<<.<<<.....<<.....>>..>>>>>>>>........................<<<<<<.<<<<..>>>>.>>>.>>>.........<<<<<<..>>>>>>. ...................(((((.(((.....((.....))..))))))))........................((((((.((((())))).))).))).........((((((())))))). Cryo-EM structure of human exon-defined spliceosome in the late pre-B state.; U4 snRNA 8h6e 2A 109 3.2 RF00004 URS00003EE995_9606 38658629 0045131 0000348 0005686 9606 cgcuucucggccaguguaguaucuguucuuaucaguuuaauaucugauggauuuuuggagcagggagccacgcaucgaccugguauugcaguaccuccaggaacggugc ..............................<<<<<........>>>>>...............<......><<<<<<.<<<<<.............>>>>>..>>>>>> ..............................(((((........)))))...............(..()..)(((.((.(((((.............)))))..)).))) Cryo-EM structure of human exon-defined spliceosome in the late pre-B state.; U2 snRNA 8h6j A 42 3.25 38658629 9606 uuuccuugaagcuuucgugcugacccugucccuuuuuuuucc .......................................... .......................................... Cryo-EM structure of human exon-defined spliceosome in the mature pre-B state.; pre-mRNA 8h6j 6A 54 3.25 RF00026 38658629 0030621 0000244,0000353 0005688,0046540 9606 uuggaaaagauuagcauggccccugcgcaaggaugacauucgugaagcguauuu ...................................................... ...................................................... Cryo-EM structure of human exon-defined spliceosome in the mature pre-B state.; U6 snRNA 8h6j 4A 125 3.25 RF00015 38658629 0017070 0000244,0000353 0005687,0046540 9606 agcuuugcgcaguggcaguaucguagccaaugaggucuauccgaggcgcgauuuugcuaauugaaaacuucccaauagccgugacgacuagucggcacuggcaauuuuugacagucucgagacug ...................<<<<<.<<<.....<<.....>>..>>>>>>>>.........................<<<<<<.<<<<..>>>>.>>>.>>>.........<<<<<<<>>>>>>> ...................(((((.(((.....((.....))..)))))))).........................((((((.((((())))).))).))).........((((((())))))) Cryo-EM structure of human exon-defined spliceosome in the mature pre-B state.; U4 snRNA 8h6j 2A 109 3.25 RF00004 URS00003EE995_9606 38658629 0045131 0000348 0005686 9606 cgcuucucggccaguguaguaucuguucuuaucaguuuaauaucugauggauuuuuggagcagggagccacgcaucgaccugguauugcaguaccuccaggaacggugc ..............................<<<<<........>>>>>...............<......><<<<<<.<<<<<.............>>>>>..>>>>>> ..............................(((((........)))))...............(..()..)(((.((.(((((.............)))))..)).))) Cryo-EM structure of human exon-defined spliceosome in the mature pre-B state.; U2 snRNA 8h6k A 64 2.7 38658629 9606 uuuccuugaagcuuucgugcugacccugucccuuuuuuuuccacccuaccaggugaguauggau ................................................................ ................................................................ Cryo-EM structure of human exon-defined spliceosome in the mature B state.; pre-mRNA 8h6k 5A 115 2.7 RF00020 URS000075BAAE_9606 38658629 0000244,0000353 0005682,0046540 9606 acucugguuucucuucagaucgcauaaaucuuucgccuuuuacuaaagauuuccguggagaggaacaacucugagucuuaacccaauuuuuugaggccuugcuuuggcaaggcua .<<<..<<<<<<<<<<<........<<<<<<<<...........>>>>>>>>...>>>>>>>>>>>......>>>...................<<<<<<<<....>>>>>>>>. .(((..(((((((((((...((...((((((((.(.......).)))))))).)))))))))))))......)))....................(((((((....))))))).. Cryo-EM structure of human exon-defined spliceosome in the mature B state.; U5 snRNA 8h6k 6A 60 2.7 RF00026 38658629 0030621 0000244,0000353 0005688,0046540 9606 aacgauacagagaagauuagcauggccccugcgcaaggaugacauucgugaagcguauuu ............................................................ ............................................................ Cryo-EM structure of human exon-defined spliceosome in the mature B state.; U6 snRNA 8h6k 4A 129 2.7 RF00015 38658629 0017070 0000244,0000353 0005687,0046540 9606 nagcuuugcgcaguggcaguaucguagccaaugaggucuauccgaggcgcgauuauugcuaauuuuuucccccgccgugacgacuugcaauauagucggcacuggcaauuuuugacagucucgagacug ....................<<<<<.<<<.....<<.....>>..>>>>>>>>....................<<<<<<.<<<<<........>>>>>.>>>.>>>.........<<<<<<<>>>>>>> ...................(((((.(((.....((.....))..))))))))....................((((((.(((((........))))).))).)))..........(((((()))))). Cryo-EM structure of human exon-defined spliceosome in the mature B state.; U4 snRNA 8h6k 2A 109 2.7 RF00004 URS00003EE995_9606 38658629 0045131 0000348 0005686 9606 cgcuucucggccaguguaguaucuguucuuaucaguuuaauaucugauggauuuuuggagcagggagccacgcaucgaccugguauugcaguaccuccaggaacggugc ..............................<<<<<........>>>>>...............<......><<<<<<.<<<<<.............>>>>>..>>>>>> ..............................(((((........)))))...............(..()..)(((.((.(((((.............)))))..)).))) Cryo-EM structure of human exon-defined spliceosome in the mature B state.; U2 snRNA 8h6l A 57 2.6 38658629 9606 uuuccuugaagcuuucgugcugacccugucccuuuuuuuuccuaccaggugaguaug ......................................................... ......................................................... Cryo-EM structure of human exon-defined spliceosome in the early B state.; pre-mRNA 8h6l 5A 115 2.6 RF00020 URS000075BAAE_9606 38658629 0000244,0000353 0005682,0046540 9606 acucugguuucucuucagaucgcauaaaucuuucgccuuuuacuaaagauuuccguggagaggaacaacucugagucuuaacccaauuuuuugaggccuugcuuuggcaaggcua .<<<..<<<<<<<<<<<........<<<<<<<<...........>>>>>>>>...>>>>>>>>>>>......>>>...................<<<<<<<<....>>>>>>>>. .(.(..(((((((((((...((...((((((((.(.......).)))))))).)))))))))))))......).)....................(((((((....))))))).. Cryo-EM structure of human exon-defined spliceosome in the early B state.; U5 snRNA 8h6l 6A 59 2.6 RF00026 38658629 0030621 0000244,0000353 0005688,0046540 9606 acgauacagagaagauuagcauggccccugcgcaaggaugacauucgugaagcguauuu ........................................................... ........................................................... Cryo-EM structure of human exon-defined spliceosome in the early B state.; U6 snRNA 8h6l 4A 129 2.6 RF00015 38658629 0017070 0000244,0000353 0005687,0046540 9606 nagcuuugcgcaguggcaguaucguagccaaugaggucuauccgaggcgcgauuauugcuaauuuuuucccccgccgugacgacuugcaauauagucggcacuggcaauuuuugacagucucgagacug ....................<<<<<.<<<.....<<.....>>..>>>>>>>>....................<<<<<<.<<<<<........>>>>>.>>>.>>>.........<<<<<<<>>>>>>> ...................(((((.(((.....((.....))..))))))))....................((((((.(((((........))))).))).)))..........(((((()))))). Cryo-EM structure of human exon-defined spliceosome in the early B state.; U4 snRNA 8h6l 2A 109 2.6 RF00004 URS00003EE995_9606 38658629 0045131 0000348 0005686 9606 cgcuucucggccaguguaguaucuguucuuaucaguuuaauaucugauggauuuuuggagcagggagccacgcaucgaccugguauugcaguaccuccaggaacggugc ..............................<<<<<........>>>>>...............<......><<<<<<.<<<<<.............>>>>>..>>>>>> ..............................(((((........)))))...............(..()..)(((.((.(((((.............)))))..)).))) Cryo-EM structure of human exon-defined spliceosome in the early B state.; U2 snRNA 8hb1 A 24 2.23 URS00026813CC_1318 36840714 1318 agagcguugcguccgaaagungcc ........................ ........................ Crystal structure of NAD-II riboswitch (two strands) with NMN; RNA (5'-R(*AP*GP*AP*GP*CP*GP*UP*UP*GP*CP*GP*UP*CP*CP*GP*AP*AP*AP*GP*UP*(CBV)P*GP*CP*C)-3') 8hb1 B 30 2.23 URS00026813C9_1318 36840714 1318 gcgacacggcucuuuaaaaacaaaaggaga .............................. .............................. Crystal structure of NAD-II riboswitch (two strands) with NMN; RNA (30-MER) 8hb3 A 24 2.87 URS00026813CC_1318 36840714 1318 agagcguugcguccgaaagungcc ........................ ........................ Crystal structure of NAD-II riboswitch (two strands) with NR; RNA (5'-R(*AP*GP*AP*GP*CP*GP*UP*UP*GP*CP*GP*UP*CP*CP*GP*AP*AP*AP*GP*UP*(CBV)P*GP*CP*C)-3') 8hb3 B 31 2.87 URS00026813C0_1318 36840714 1318 gcgacacggcucuuuaaaaacaaaaggagaa ............................... ............................... Crystal structure of NAD-II riboswitch (two strands) with NR; RNA (31-MER) 8hba A 48 2.64 URS00026813CB_1318 36840714 1318 gcggcguugcguccgaaagugacacggccgcuuaaaaacaaaaggaga <<<<<..<...(((....<<.>>..>>>>>>............))).. ((((((...[.[[[....((.)).).)))))............]]]]. Crystal structure of NAD-II riboswitch (single strand) with NAD; RNA (55-MER) 8hba B 50 2.64 URS00026813CB_1318 36840714 1318 cgcggcguugcguccgaaagucgacacggccgcuuaaaaacaaaaggaga .<<<<<..<...(((....<<..>>..>>>>>>............))).. .((((((...[.[[[....((())).).)))))............]]]]. Crystal structure of NAD-II riboswitch (single strand) with NAD; RNA (55-MER) 8hf0 P 47 3.72 URS00023358B9_7227 37633971 7227 gagacuugggcaaugugacugcugaucagcagucacauugcccaagu ............................................... ............................................... DmDcr-2/R2D2/LoqsPD with 50bp-dsRNA in Dimer state; RNA (52-MER) 8hf0 N 50 3.72 URS00023358B9_7227 37633971 7227 gacuugggcaaugugacugcugaucagcagucacauugcccaagucucuu .................................................. .................................................. DmDcr-2/R2D2/LoqsPD with 50bp-dsRNA in Dimer state; RNA (52-MER) 8hf1 H 11 3.7 URS0002681479_7227 37633971 7227 ccaagucucuu ........... ........... DmDcr-2/R2D2/LoqsPD with 19bp-dsRNA in Trimer state; RNA (5'-R(P*CP*CP*AP*AP*GP*UP*CP*UP*CP*UP*U)-3') 8hf1 K 11 3.7 URS0002681479_7227 37633971 7227 ccaagucucuu ........... ........... DmDcr-2/R2D2/LoqsPD with 19bp-dsRNA in Trimer state; RNA (5'-R(P*CP*CP*AP*AP*GP*UP*CP*UP*CP*UP*U)-3') 8hf1 M 11 3.7 URS0002681479_7227 37633971 7227 ccaagucucuu ........... ........... DmDcr-2/R2D2/LoqsPD with 19bp-dsRNA in Trimer state; RNA (5'-R(P*CP*CP*AP*AP*GP*UP*CP*UP*CP*UP*U)-3') 8hfr 1e 3274 2.64 RF02543 URS000061F377_559292 37258668 0003735 0005840 559292 ugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacgccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguagugagggccuuggucagacgcagcgggcgugcuuguggacugcuugguggggcuugcucugcuaggcggacuacuugcgugccuuguuguagacggccuugguaggucucuuguagaccgucgcuugcuacaauuaacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcguggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauagaggguguagaauaagugggagcuucggcgccagugaaauaccacuaccuuuauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu .......................<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..<<<..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<.<<<<<....<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>>..>>>........>>>>>>>>>>>........<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<....<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<........>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<...................<<<<<.....>>>>>................>>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>.........<<..............>>.....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..[[[..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<<....>>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<.........<<.....................<<<<<<<........<<<<.......<.....>......>>>>........>>>>>>>.....................<<<<<.....>>>>>.....>>..............>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<<.<<<..<<<<<..<..<<<.....<<<<....>>>>.....>>>>.>>>..>>>>>..>>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<........<<<<<.<<<<<<..<<<<<.<<<<<<<<..<<<<<<<<<<<<<<..<...........<<..........................>>..>..>>>>.>>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))......<<<<<<<..<<<<.))))))>>>>>>>>>>>.........>>>>..>>>>>>>..............<<<<<....<.......>....>>>>>.............((...<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.....))..>>>.....>>>>>..>...>>>>......<<<<<<<....>>>.>>>>........>>>.>>>>>....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<....<<<<<<<<<<]]].>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<..<<<.......<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>................>>>..>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<.<..<<<<<......>>>>>..>>>>>...>>>....>>>>.>>>>>..>>>>>.. .......................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((..(.(((.((((((((...({((((......)))))[[(...).(((....}]])))....))))))))...)))..).....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.(((((....(((((((((((((((((((((((.......(((((((......((((........)))).......))))))).....))))).))))))))))........(((....)))....)))))))).....))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(.(....(............(.(((((.....))))).)..........)..)..).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........(.((............))).....))....))...(((((........)))))]]((((..(((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((..{{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((...........(......................((.............((((.....(.......)....)))).............).)......................((((.....)))).......)...............)..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))..)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..((((.......(((((.((((((..(((((.((((((((..(((((((((((((.(.(.......[...(..(....................].)..)..)..)))).))))))))))....((((.....((((..((((........))))...........>...(((((......)))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))))..............(((((...(.........)...)))))..............[...((((.((((((..(.(((((((......))))))..).).(((.....]...))).....)))))..)...))))......(((((((....))).))))..>..)..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}}.)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......(.((...((........((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).................))...)).)..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(((.((..)..).)))..)))))...)))....)))).)))))).))))).. NPC-trapped pre-60S particle; 25S ribosomal RNA 8hfr 2f 121 2.64 RF00001 URS000055688D_559292 37258668 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). NPC-trapped pre-60S particle; 5S ribosomal RNA 8hfr 3n 156 2.64 RF00002 URS00001BF64E_559292 37258668 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucau .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))................... NPC-trapped pre-60S particle; 5.8S ribosomal RNA 8hke C 37 3.71 URS00029156C7_9606 38664565 9606 gggcaaugugacugcaucagcagucacauugcccaag ..................................... ..................................... dsRNA transporter; RNA (37-MER) 8hke D 37 3.71 URS00029156A9_9606 38664565 9606 cuugggcaaugugacugcugaugcagucacauugccc ..................................... ..................................... dsRNA transporter; RNA (37-MER) 8hku A23S 2995 2.72 RF02540,RF02541,RF02543,RF00002 URS0000759EE6_330779 37604686 0003735 0005840 330779 aagccucccgguggauggcucggcucgggcaccgaagaagggcgcggcaagcagcgaaaugcucgggugaggcgcaagcagccguugaccccgagguccccuaaugggauauccugccggguuuccggcucccgguuuauaacugggugggaaccccccgaacggaaacaucuuaguagggggaggaaaagaaaucaauugagauccccugaguaggggcgaccgaaagggggacagcccaaacuaaaccugccgaugauaagucgguggggaugugguguuacgaccucuagccugagguugaccucggcuuuccuaaccuaucuagccgaacuccccuggaacggggggccauagagggugaaagccccguaggcuaaagauagguggaaaguggcuagagguagaguaccauccccugguuugggggugggaaguuaggggacacgugccucuaaggcuaaauaugucccgagaccgauagcaaacuaaguaccgugagggaaagcugaaaagaaccccggaagggggagugcaaagagccugaaaccgggugguuauacaggguguggcucgaaagaagugaacccuuccgaaggaaaggggcgcaagcccuuaguacgaggaagggcgaucggggucacgccuuucgucuugaaacacgggccggggaguucacaucaguggcgagcuuaaggagauuaucuccgaaggcauagggaaaccaagugcccgcagccuaguuucuaggcgaggggcagggucugucagggccugaagccacugaugugaggcuagaaaccgggcgaucuaguccggggcaggcugaaggugggggaaaccccacuggagggccgaauagggguucugacgugcaauucguucccuugaccucggacuaggggcaaaagaccaaucuagcccggugauagcuaguuccccccgaaaugcguccuagcgcagccucccuaaaggcagcucgcgggguagagugacagaucgggggcuccaggcgccuggggcuuccggucuaacuccgaacccacgagcgccgaagaaggggggagugggucacucggcguaagguuggguggcaaaaggggaacaacccagaccuggguuaaggccccaaagucccggcuaagugccaacgaaaaggcgucuccagccuuagacagcgggaaggugggcccagcagcagccauccucuaaggagugcguaacagcucacccgccgaggcuggaggcccuaaagauuggucggggcucaagccgggcgccgagacccaggagggggucucuacuagagauccucugguaggggggcgcugugaugggguagaaggugggucgugagauccacuggacccgucacaggugcagaucccggcgguaguaacagcgaaggggggugagaaucccccucgccggaagggcaaggguuucccggcaacguucgucagccgggaguuagccgguccuaagguagggccuaauagguaccuaccgaaagggaaagggguuaacauuccccugccucccggguaggugcgguaacgcaagccagacuccugacggauugggguagggagaguaggaccaccguccuacccaagcacucaagcccuuggagagccguaacggugagaagagggcgaaggugugaugggccuuccguuaggaggguucuccugaucccuaguccccaugaaaagggagucuggaacgaucccgggagaccguaccuagaaccgacacuggugccccggugagaagcccaaggcgucugagggguaacccaggcuagggaacucggcaaauuagccccguaacuucgggagaaggggugccuaucgugguuuaacaaagccacgauaggucgcagugaccagagggaccugacuguuuaauaaaaacauagguccccgcuagcccgaaaggguguguacgggggcuaaauccuggccacuggugguugguuaaauccggguucaaccgggcgaagccccaccgaaggccggggguacccucuuaagguagccaaaugccuugccggguaaguuccggcgcgcaugaauggaucaacgcggucccuacugucccagccuggggccucgugaacgcccugagccggugcacaguccggcaucucccuacaccgagagaagaccccguggagcuucaccgcagccuggcguugucccucgggcguuuaugcguagaguaggugggaggggucgaaccuguccuuucgggggcaggggacccgaaagugaaacaccacccauggacgcucgagggacuaaccucucgaaagagaggaacaacgucaggugggcgguucggcuggggcggcacucccgcgaaaagauaacacgggagcccaaaggucggcucaggcgguacagaacgccgccguagagcgcaagggcaaaagccggccugacgugacccuuccaaguacggggucacgacgcgaaagcggggccuagcgaacgcucgugcccccacacgugggggccgggcaugacagaaaaguuaccccggggauaacagggucgucgcgggcgagagcucacaucgaccccgcgguuugcuacaucgaugucggcucuucccacccuggaggugcagcugccuccaaggguagggcugcccgcccguuaaaggggagcgugagcuggguuuagaccgucgcgagacaggucggacucuaaggguagggagugcggaccgcuugaggggaaggaaccccuaguacgagaggaacaggguuccggggccuccaguuuaccgguuguccgguagggcaaugccgggcagccgcgcccugagggguaaccgcugaaagcaucuaagcgggaaccccuccccuaaaagaggcggucaggcgccggggccuuccccuagaagaggggguugaugggguggggauguaagcuccaagguuguaagaccgaggaguuuaguccgccacucccaaucaggcuccccc ..<<<.<<<<<<....<<<..<<<<<<<<<<<<<....<<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>>...<<<....>>><<<<<....>>>>>..<<<<<<...>>>>>>.>>>...<<<<<<....<<......>>.....>>>>>.>.........<<<..>>>..<<<<<<.....<<.....>>....>>>>>>..<<<...<<<...<<<<<<<<<.....>>>>>>>>>.....>>>......<<<<<<<<<<<<<<<<..>>>>>><<<<<<<..<<<<<<<<<<<<.....<<<<......>>>>.((......<<<.....))>>>...>>>>..>>>>>>>>>>>>>>>>>>>>>>>>>......<<<<<<<<......>>>>>>>>......<<<<<.((((((>>>>>..>>>......>>.>>>>>>.>>................<<....>>....>>.........<<<<.....>>>>............>....>>>>>>.>>>.......<<<<<<<<<<....<<......<<<<<<<...<....<<<<<....>>>>>.....>..>>>>>>>...>>.>>>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>...<<<<<...<<<<.......>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>..<<<<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<<.....<<........>>...>>>>...>>>>>>>>>...<<.......>>......>>>>>>...>..>>>>..<<<<<<....<<<<<....>>>>><<<<<<<<...<<<.<<<<<.<<<...<<<....<<<<<<<<<<<<<<<<<<>>>>>>>>>>>>>>>>>>..>>.>...>>>.>>>>>>>>......>>>>>>.>>..<<<<<<<<<<.....>>>>>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<........<<<.<<<<<<<<<<.......<<<<<..<....<<.........>.>...>..........<<......>>...>>>>>...>>>>>>>>>>>>>...........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<<<<<...>>>>>>>>>>>....>>>>>><<<<<<<<<.<<<.....<<<<<<<<....>>>>>>>>...>>>>>>>>>>.>>.....>>>>>><......<<......<<<<<<.......>>>>>><<<<....<<<<<<<<...<<<<<<....<.....>..>>>>>>....((<<<<<<...<<<<<<<<<.....>>>.>>>>>>....>>>..<<<<<........>>>>>))<<<<<<<<.....<<<....>>>...<<<<<<<<<<...<<<<<<<<<..<<<<<<<<<<<<<.[[[>>>>>>><<..<<<<<...<<<<<<.....<<<<...>>>>.....>>>>>>...>>>>>...>><<<<<<<....>>>>>>>>>>>>>...>>>>>>>>>.........>>>>>>>>>>......>>>>>>>>.>>>..>>>....<<......>>>>>>>.<<<.....>>>...>>>>...<<<<.....<<<<<<<<.<<...............<<<<<....<<..>>.....>>>>><<<<<<<<<<<<<......>>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<....>>>>......>>>>>>>..<<<<.<<<..<<<<<<<..<<<....<<<<<......>>>>>....>>>>>>>>..>>>>><<<<<..>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>...>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<..<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<<<<<<<<<<<<.........<<<<<..<<<......<<.<.<<<.....>>>>.>>...>>>............>>>>>>>>>>>>>>>>>>>>>>>...<<<<<<....>>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<.............>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<..))))))>>>>>>>>>>..........>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>..<<<<.....>>>>......>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>...>>>>>>>>>>....<<<<<<<..<<<<<..<<<<<<<.................>>>>>>><<<<<...<.<<...<<<<<<<<<<]]].>>>>>..>>>>>...>>.>.>>>>>.<<<<<...<<<<<...........>>>>>...>>>>>>>>>>......>>>>>>>.<<..>><<<<<<<<<<<<.......>>>>>....<<<<<<<<<<<<....<<<<<..<<<<....>>>>..>>>>>...>>>>.>>>>>.>>>...>>>>>>>... ..(((.(((((.....(((..(((((.((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))(((((....)))))..((.((.....)).))..))...((((((....((...[..)).....))))).).........((....))...(((((.....((.]...))....)))))...(..(...((..((((((((((.....)))))))))....)))....[..((((((((((.(((((..))))).(((((((...(((((((.(((...({((((......)))))[[......(((....}]])))...)))...))))))).))))))))))))))))).)....((((((((......))))))))....]...(((.[[[[[[)))......)......)).)).))).))................((....))....))......(..((((.....))))...........)).....))))).))).......((((((((((....((......(((((.(...(....(((((....))))).....)..).)))))...)).)))))))))).[((((........))))((((((....(((((((((((((..(((...((((.....))))...)))...((....))...(((((...((((.......))))...)))))((((((....))))))...)))))))))))))..((((...((((((.....((((((((((.((((...(((((((....)))))))...)[))).....(((...(.((........)))..)))..).))))))))).(.((.......))...)..))))))......))))..((((((....(((((....)))))((((((((...(((.(((((.(((...(((....(((.(((((((.(((((()))))).))))))).)))..)).)...))).))))))))......)))))).))..((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((........(((.((((((((((.......(((((..(([..((.........).)..))......(]..((......)).).)))))...)))))))))))))...........]]]))....))))))))))...)))))))(((((((((((...)))))))))))....))))))(.(((((((.(((.....((((((((....))))))))...))))))))))..).....))))))(......((......((((((.......))))))((((....((((..((..(((((((....(.....)..))))))....[[(((.((...(((((((((.....))).))))))....))...(((............)))]]((((((((.....(((....)))...(((((((((....(((((((((..((((((((((((..{.{.))))))((..(((((...((((((.....(((.....))).....))))))...)))))...))(((((((....)))))))))))))...)))))))))(...).....)))))))))......)))))))).))).))).....((......)).)))).(((.....)))...))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((((((......)))))))))))))(...).......(((((((((.].((.........))...(((((((....((((....))))......))))))).}.(((.(((..(((((((..(((.....((((......)))).....))))))))..)))))(.(((()))).)........((.(......).(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).)))))).....).{...(((((.....]}.)))))..((((((((.((..((......((((.((((((..(((((.(((((((((.((((((((.(((((((.(.........(((((..(((......(..(.(((....).)))..)...)))............)))))).))))))).))))))))...((((((....))))))....)))))))))..)))))..(((......[)).)(((((...........].)))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((..]]]]]]))))))))))....).....))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..)))..((((.....))))......)))))..)...))).).....(((((((....))).))))....))...))))))))))....(((((((...((((..(((((((......(....).....)))))))(((((...(.((...((((((((((}.}.)))))..))))).[.)).).))))).(((((...((((.............))))...))))))))).......))))))).((()))(((((((.((((.......)))).....((((((((((((....(((((..((((....))))..)))))...))))]))))).)))...)))))))... Cryo-EM Structures and Translocation Mechanism of Crenarchaeota Ribosome; 23s rRNA (2996-MER) 8hku A5S 122 2.72 RF00001 URS000056704D_330779 37604686 0003735 0005840 330779 ugcccacccggucauagugagcggguaacacccggacucguuucgaacccggaaguuaagccgcucacgucagaggggccgugggauccgagagggcccgcagccucucugagcugggaugg ..<<..<<<<<<....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>>>.<<<<<<<<<<.<<<<<..<<....>>.>>>>>.>>>>>>>>>>>>>>>>..>> ..((..((((((....((((((((.....((((((...(.....)...))))..))....)))))))).((((((((((.(((((..((....)).))))).))))))))))))))))..)) Cryo-EM Structures and Translocation Mechanism of Crenarchaeota Ribosome; 5s rRNA (122-MER) 8hku AETN 18 2.72 RF00005 URS0002681451_330779 37604686 0030533 330779 gcccggauccgggcacca <<<<<<..>>>>>>.... ((((((())))))).... Cryo-EM Structures and Translocation Mechanism of Crenarchaeota Ribosome; E-site tRNA 8hkv A23S 2989 4.94 RF02540,RF02541,RF02543,RF00002 URS0000759EE6_330779 37604686 0003735 0005840 330779 aagccucccgguggauggcucggcucgggcaccgaagaagggcgcggcaagcagcgaaaugcucgggugaggcgcaagcagccguugaccccgagguccccuaaugggauauccugccggguuuccggcucccgguuuauaacugggugggaaccccccgaacggaaacaucuuaguagggggaggaaaagaaaucaauugagauccccugaguaggggcgaccgaaagggggacagcccaaacuaaaccugccgaugauaagucgguggggaugugguguuacgaccucuagccugagguugaccucggcuuuccuaaccuaucuagccgaacuccccuggaacggggggccauagagggugaaagccccguaggcuaaagauagguggaaaguggcuagagguagaguaccauccccugguuugggggugggaaguuaggggacacgugccucuaaggcuaaauaugucccgagaccgauagcaaacuaaguaccgugagggaaagcugaaaagaaccccggaagggggagugcaaagagccugaaaccgggugguuauacaggguguggcucgaaagaagugaacccuuccgaaggaaaggggcgcaagcccuuaguacgaggaagggcgaucggggucacgccuuucgucuugaaacacgggccggggaguucacaucaguggcgagcuuaaggagauuaucuccgaaggcauagggaaaccaagugcccgcagccuaguuucuaggcgaggggcagggucugucagggccugaagccacugaugugaggcuagaaaccgggcgaucuaguccggggcaggcugaaggugggggaaaccccacuggagggccgaauagggguucugacgugcaauucguucccuugaccucggacuaggggcaaaagaccaaucuagcccggugauagcuaguuccccccgaaaugcguccuagcgcagccucccuaaaggcagcucgcgggguagagugacagaucgggggcuccaggcgccuggggcuuccggucuaacuccgaacccacgagcgccgaagaaggggggagugggucacucggcguaagguuggguggcaaaaggggaacaacccagaccuggguuaaggccccaaagucccggcuaagugccaacgaaaaggcgucuccagccuuagacagcgggaaggugggcccagcagcagccauccucuaaggagugcguaacagcucacccgccgaggcuggaggcccuaaagauuggucggggcucaagccgggcgccgagacccaggagggggucuacugagauccucugguaggggggcgcugugaugggguagaaggugggucgugagauccacuggacccgucacaggugcagaucccggcgguaguaacagcgaaggggggugagaaucccccucgccggaagggcaaggguuucccggcaacguucgucagccgggaguuagcguccuaagguagggccuaauagguaccuaccgaaagggaaagggguuaacauuccccugccucccggguaggugcgguaacgcaagccagacuccugacggauugggguagggagaguaggaccaccguccuacccaagcacucaagcccuuggagagccguaacggugagaagagggcgaaggugugaugggccuuccguuaggaggguucuccugaucccuaguccccaugaaaagggagucuggaacgaucccgggagaccguaccuagaaccgacacuggugcccgggugagaagcccaaggcgucugagggguaacccaggcuagggaacucggcaaauuagccccguaacuucgggagaaggggugccuaucgugguuuaacaaagccacgauaggucgcagugaccagagggaccugacuguuuaauaaaaacauagguccccgcuagcccgaaaggguguguacgggggcuaaauccugccacuggugguugguuaaauccggguucaaccgggcgaagccccaccgaaggccggggguacccucuuaagguagccaaaugccuugccggguaaguuccggcgcgcaugaauggaucaacgcggucccuacugucccagccuggggccucgugaacgcccugagccggugcacaguccggcaucucccuacaccgagagaagaccccguggagcuucaccgcagccuggcguugucccucgggcguuuaugcguagaguaggugggaggggucgaaccuguccuuucgggggcaggggacccgaaagugaaacaccacccauggacgcucgagggacuaaccucucgaaagagaggaacaacgucaggugggcgguucggcuggggcggcacucccgcgaaaagauaacacgggagcccaaaggucggcucaggcgguacagaacgccgccguagagcgcaagggcaaaagccggccugacgugacccuuccaaguacggggucacgacgcgaaagcggggccuagcgaacgcucgugcccccacacgugggggccgggcaugacagaaaaguuaccccggggauaacagggucgucgcgggcgagagcucacaucgaccccgcgguuugcuacaucgaugucggcucuucccacccuggaggugcagcugccuccaaggguagggcugcccgcccguuaaaggggagcgugagcuggguuuagaccgucgcgagacaggucggacucuaaggguagggagugcggaccgcuugaggggaaggaaccccuaguacgagaggaacaggguuccggggccuccaguuuaccgguuguccgguagggcaaugccgggcagccgcgcccugagggguaaccgcugaaagcaucuaagcgggaaccccuccccuaaaagaggcggucaggcgccggggccuuccccuagaagaggggguugaugggguggggauguaagcuccaagguuguaagaccgaggaguuuaguccgccacucccaaucaggcuccccc ..<<<.<<<<<<....<<<..<<<<<<<<<<<<<....<<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>>...<<<....>>><<<<<....>>>>>..<<<<<.....>>>>>.>>>...<<<<<<....<<<....>>>.....>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<...<<<...<<<<<<<<<.....>>>>>>>>>.....>>>......<<<<<<<<<<<<<<<<..>>>>>><<<<<<<..<<<<<<<<.<<<.....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>>>>>>>>>>>>......<<<<<<<<......>>>>>>>>......<<<<<.((((((>>>>>..>>>......>>.>>>>>>.>>................<<....>>....>>.........<<<<.....>>>>............>....>>>>>>.>>>.......<<<<<<<<<<....<<......<<<<<<<...<....<<<<<....>>>>>.....>..>>>>>>>...>>.>>>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>...<<<<<...<<<<.......>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>..<<<<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<<<....<<........>>..>>>>>...>>>>>>>>>...<<.......>>......>>>>>>......>>>>..<<<<<<....<<<<<....>>>>><<<<<<<<...<<<.<<<<<.<<<...<<<....<<<<<<<<<<<<<<<<<<>>>>>>>>>>>>>>>>>>..>>.>...>>>.>>>>>>>>......>>>>>>.>>..<<<<<<<<<<.....>>>>>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>...........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.<...>.>.>>>>>>....>>>>>><<<<<<<<<.<<<.....<<<<<<<<....>>>>>>>>...>>>>>>>>>>.>>.....>>>>>><......<<......<<<<<<.......>>>>>><<<<....<<<<<<<<...<<<<<<....<.....>..>>>>>>....(.<<<<...<<<<<<<<<.....>>>.>>>>>>....>>....<<<<........>>>>..)<<<<<<<<.....<<<....>>>...<<<<<<<<<<...<<<<<<<<<..<<<<<<<<<<<<..[[[.>>>>>><...<<<<<...<<<<<<.....<<<<...>>>>.....>>>>>>...>>>>>....><<<<<<<....>>>>>>>>>>>>>...>>>>>>>>>.........>>>>>>>>>>......>>>>>>>>>>....>>>....<<......>>>>>>><<<<.....>>>>..>>>>...<<<<.....<<<<<<<<.<<...............<<<<<....<<..>>.....>>>>><<<<<<<<<<<<<......>>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<....>>>>......>>>>>>>..<<<<.<<..<<<<<<<..<<<....<<<<<......>>>>>....>>>>>>>>..>>>>.<<<<<..>>>>>....................<<<<<<.....>>>>>>..........>>>>...>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<..<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<<<<<<<<<<<<.........<<<<<..<<<......<.<<.<<<.....>>>>.>>...>>>............>>>>>>>>>>>>>>>>>>>>>>>...<<<<<<....>>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<.............>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<..))))))>>>>>>>>>>..........>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<.<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>..<<<<.....>>>>......>>>>>..>...>>>..>....<<<<<<<....>>>.>>>>....>>...>>>>>>>>>>....<<<<<<<..<<<<<..<<<<<<<.................>>>>>>><<<<<.....<<...<<<<<<<<<<]]].>>>>>..>>>>>...>>...>>>>>.<<<<<...<<<<<...........>>>>>...>>>>>>>>>>......>>>>>>>.<<..>><<<<<<<.<<<<.......>>>>.....<<<<<<<<<<<<....<<<<<..<<<<....>>>>..>>>>>...>>>>.>>>>>.>>>...>>>>>>>... ...((.(((((.....(((..(((((.((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...))).....((....)).(((((....)))))..((.((.....)).))..))...((((((....((...[..)).....))))).).........((....))...(((((.....((.]...))....)))))...(..(...(...((((((((((.....)))))))))....).)....[..(((((((((..(((((())))))..((((((...(((((((.(((...({((((......)))))[[......(((....}]])))...)))...))))))).))))))..))))))))).)....((((((((......))))))))....]...(((.[[[[[[)))......)......)).)).))).))................((....))....))......(..((((.....))))...........)).....))))).))........(.((((((((....((......(((((.(...(....(((((....))))).....)..).)))))...)).)))))))).).[((((........))))((((((....(((((((((((((..((....((((.....))))....))...((....))...(((((...((((.......))))...)))))((((((....))))))...)))))))))))))..((((...((((((.....((((((((((.((((...(((((((....)))))))...)[))).....(((...(.((........)))..)))..).))))))))).(.((.......))...)..))))))......))))..((((((....(((((....)))))((((((((...(((.(((((.(((...(((....(((((((..((((((((()))))))))..)))))))..)).)...))).))))))))......)))))).))..((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((........(((.((((((((((.......(((((.(((...(.(........).)..))).....(...((......)).).)))))...)))))))))))))...........]]]))....))))))))))...)))))))(((((((.......).))))))....))))))(.((((((..(((......(((((((....)))))))....))).))))))..).....))))))(......((......((((((.......))))))((((....((((..((..(((((((....(.....)..))))))....(([.((...(((((((((.....))).))))))....))....((............)).))((((((((.....(((....)))...(((((((((....(((((((((...(((((((((((..{.{.)))))).(..(((((...((((((.....(((.....))).....))))))...)))))...)..((((((....)))))).)))))....)))))))))(...).....)))))))))......)))))))).]...))).....((......)).))))((((.....))))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((((((......)))))))))))))(...).......(((((((((.].((.........))....((((((....((((....))))......))))))..}.(((.((..(((((((..(((.....((((......)))).....))))))))..)))).(.(((()))).).........(.(......).(((((.......)))))..).......)))....)).))))))).)..))).)))))))).)))))).....).{...(((((.....]}.)))))..((((((((.((..((......((((.(((.((..(((((.(((((((((.((((((((.((((..(.(.........(((((..(((......(.((.(((....).))).))...)))............)))))).)..)))).))))))))...((((((....))))))....)))))))))..)))))..((.......[.).)(((((...........].)))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....((.((.(((((..]]]]]]))))))).))....).....)).)..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......(.((.((((((..((((((((........)))))..)))..((((.....))))......)))))..)...))..).....(((((((....))).))))....))...))))))))))....(((((((...((((..(((((((......(....).....)))))))(((((...(.((...((((((((((}.}.)))))..))))).[.).)).))))).(((((...((((.............))))...))))))))).......))))))).((())).((((((.((((.......)))).....((((((((((((....(((((..(((......)))..)))))...))))]))))).)))...))))).)... Cryo-EM Structures and Translocation Mechanism of Crenarchaeota Ribosome; 23s rRNA (2996-MER) 8hkv A5S 122 4.94 RF00001 URS000056704D_330779 37604686 0003735 0005840 330779 ugcccacccggucauagugagcggguaacacccggacucguuucgaacccggaaguuaagccgcucacgucagaggggccgugggauccgagagggcccgcagccucucugagcugggaugg ..<<..<<<<<<....<<<<<<<<.....<<<<<<.............>>>>..>>....>>>>>>>>.<<<<<<<<<<.<<<<<..<<....>>.>>>>>.>>>>>>>>>>>>>>>>..>> ..((..((((((....((((((((.....((((((...(.....)...))))..))....)))))))).(((((((((..(((((..((....)).)))))..)))))))))))))))..)) Cryo-EM Structures and Translocation Mechanism of Crenarchaeota Ribosome; 5s rRNA (122-MER) 8hky A23S 2996 4.45 RF02540,RF02541,RF02543,RF00002 URS0000759EE6_330779 37604686 0003735 0005840 330779 aagccucccgguggauggcucggcucgggcaccgaagaagggcgcggcaagcagcgaaaugcucgggugaggcgcaagcagccguugaccccgagguccccuaaugggauauccugccggguuuccggcgcccgguuuauaacugggugggaaccccccgaacggaaacaucuuaguagggggaggaaaagaaaucaauugagauccccugaguaggggcgaccgaaagggggacagcccaaacuaaaccugccgaugauaagucgguggggaugugguguuacgaccucuagccugagguugaccucggcuuuccuaaccuaucuagccgaacuccccuggaacggggggccauagagggugaaagccccguaggcuaaagauagguggaaaguggcuagagguagaguaccauccccugguuugggggugggaaguuaggggacacgugccucuaaggcuaaauaugucccgagaccgauagcaaacuaaguaccgugagggaaagcugaaaagaaccccggaagggggagugcaaagagccugaaaccgggugguuauacaggguguggcucgaaagaagugaacccuuccgaaggaaaggggcgcaagcccuuaguacgaggaagggcgaucggggucacgccuuucgucuugaaacacgggccggggaguucacaucaguggcgagcuuaaggagauuaucuccgaaggcauagggaaaccaagugcccgcagccuaguuucuaggcgaggggcagggucugucagggccugaagccacugaugugaggcuagaaaccgggcgaucuaguccggggcaggcugaaggugggggaaaccccacuggagggccgaauagggguucugacgugcaauucguucccuugaccucggacuaggggcaaaagaccaaucuagcccggugauagcuaguuccccccgaaaugcguccuagcgcagccucccuaaaggcagcucgcgggguagagugacagaucgggggcuccaggcgccuggggcuuccggucuaacuccgaacccacgagcgccgaagaaggggggagugggucacucggcguaagguuggguggcaaaaggggaacaacccagaccuggguuaaggccccaaagucccggcuaagugccaacgaaaaggcgucuccagccuuagacagcgggaaggugggcccagcagcagccauccucuaaggagugcguaacagcucacccgccgaggcuggaggcccuaaagauuggucggggcucaagccgggcgccgagacccaggagggggucucuacugagauccucugguaggggggcgcugugaugggguagaaggugggucgugagauccacuggacccgucacaggugcagaucccggcgguaguaacagcgaaggggggugagaaucccccucgccggaagggcaaggguuucccggcaacguucgucagccgggaguuagccuccuaagguagggccuaauagguaccuaccgaaagggaaagggguuaacauuccccugccucccggguaggugcgguaacgcaagccagacuccugacggauugggguagggagaguaggaccaccguccuacccaagcacucaagcccuuggagagccguaacggugagaagagggcgaaggugugaugggccuuccguuaggaggguucuccugaucccuaguccccaugaaaagggagucuggaacgaucccgggagaccguaccuagaaccgacacuggugcccgggugagaagcccaaggcgucugagggguaacccaggcuagggaacucggcaaauuagccccguaacuucgggagaaggggugccuaucgugguuuaacaaagccacgauaggucgcagugaccagagggaccugacuguuuaauaaaaacauagguccccgcuagcccgaaaggguguguacgggggcuaaauccuggccacuggugguugaaauccggguucaaccgggcgaagccccaccgaaggccggggguaacucugacccucuuaagguagccaaaugccuugccggguaaguuccggcgcgcaugaauggaucaacgcggucccuacugucccagccuggggccucgugaacgcccugagccggugcacaguccggcaucucccuacaccgagagaagaccccguggagcuucaccgcagccuggcguugucccucgggcguuuaugcguagaguaggugggaggggucgaaccuguccuuucgggggcaggggacccgaaagugaaacaccacccauggacgcucgagggacuaaccucucgaaagagaggaacaacgucaggugggcgguucggcuggggcggcacucccgcgaaaagauaacacgggagcccaaaggucggcucaggcgguacagaacgccgccguagagcgcaagggcaaaagccggccugacgugacccuuccaaguacggggucacgacgcgaaagcggggccuagcgaacgcucgugcccccacacgugggggccgggcaugacagaaaaguuaccccggggauaacagggucgucgcgggcgagagcucacaucgaccccgcgguuugcuacaucgaugucggcucuucccacccuggaggugcagcugccuccaaggguagggcugcccgcccguuaaaggggagcgugagcuggguuuagaccgucgcgagacaggucggacucuaaggguagggagugcggaccgcuugaggggaaggaaccccuaguacgagaggaacaggguuccggggccuccaguuuaccgguuguccgguagggcaaugccgggcagccgcgcccugagggguaaccgcugaaagcaucuaagcgggaaccccuccccuaaaagaggcggucaggcgccggggccuuccccuagaagaggggguugaugggguggggauguaagcuccaagguuguaagaccgaggaguuuaguccgccacucccaaucaggcuccccc ..<<<.<<<<<<....<<<..<<<<<<<<<<<<.....<<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>>...<<<....>>><<<<<<..>>>>>><<<<<<<.....>>>>>>>>>...<<<<<<....<<<....>>>.....>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<...<<<...<<<<<<<<<.....>>>>>>>>>.....>>>......<<<<<<<<<<<<<<<<..>>>>>><<<<<<<..<<<<<<<<.<<<.....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>>>>>>>>>>>>......<<<<<<<<......>>>>>>>>........<<<.((((((>>>....>>>......>>.>>>>>>.>>................<<....>>....>>.........<<<<.....>>>>............>....>>>>>>.>>>......<<<<<<<<<<<....<<......<<<<<<<...<....<<<<<....>>>>>.....>..>>>>>>>...>>.>>>>>>>>>>>.<<<<........>>>><<<<<<...<<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>...<<<<<...<<<<.......>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>>.<<<<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<<<....<<........>>..>>>>>...>>>>>>>>>...<<.......>>......>>>>>>......>>>>..<<<<<<....<<<<<....>>>>><<<<<<<<...<<<.<<<<<.<<<...<<<....<...<<<<<<<<<<<<<..>>>>>>>>>>>>>...>..>>.>...>>>.>>>>>>>>......>>>>>>.>>..<<<<<<.<<<.....>>>.>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<........<<<.<<<<<<<<<........<<<<<.<<.....................>>.........<<......>>...>>>>>....>>>>>>>>>>>>...........)))>>....>>>>>>.>>>...>>>>>>><<<<<..<<<....>>>..>>>>>....>>>>>><<<<<<<<<.<<<.....<<<<<<<<....>>>>>>>>...>>>>>>>>>>.>>.....>>>>>><......<<......<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<....<.....>..>>>>>>....<<.<<<...<<<<<<<<<.....>>>.>>>>>>....>>>..<<<<<........>>>>>>><<<<<<<<.....<<<....>>>...<<<<<<<<<<...<<<<<<<<<.<.<<<<<<<<<<<..[[[.>>>>>><<..<<<<<...<<<<<<.....<<<.....>>>.....>>>>>>...>>>>>...>><<<<<<<....>>>>>>>>>>>>>...>>>>>>>>>.........>>>>>>>>>>......>>>>>>>>......>>.....<<......>>>>>>><<<<.....>>>>..>>>>...<<<<.....<<<<<<<<.<<...............<<<<<....<....>.....>>>>><<<<<<<<<<<<<......>>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<....>>>>......>>>>>>>..<<<<.<<<..<<<<<<<.......<<<<......>>>>........>>>>>..>>>>>.<<<<.........>>>>.........<...........<<<<<<.....>>>>>>.....>....>>>>...>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<..<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<<<<<<...............<<.<<...<..........<.<.<.....>.>>.......>.............>>.>>......>>>>>>>>>>>>...<<<<<<....>>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<.............>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<..))))))>>>>>>>>>>..........>>>>..>>>>>>.......<<<<..<<<<<<<...<<.......>>...>>>>>>>...>>>.>........<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>..>...>>>.>.....<<<<<<<....>>>.>>>>....>>...>>>>>>>>>>....<<<<<<<..<<<<<..<<<<<<<.................>>>>>>><<<<<.....<<...<<<<<<<<<<]]].>>>>>..>>>>>...>>...>>>>>.<<<<<...<<<<<...........>>>>>...>>>>>>>>>>......>>>>>>>.<<..>>.<<<<<<<<<<<.......>>>>>....<<<<<<<<<<<<....<<<<<..<<<<....>>>>..>>>>>...>>>>.>>>>>.>>>...>>>>>>.... ..(((.(((((.....(((..(((((.((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))(((((....))))).((((((.....)))))).))...((((((....((...[..)).....))))).).........((....))...(((((.....((.]...))....)))))...((((...((..((((.((((.......)))).)))....)))....[..((((((((((.(((((..))))).(((((((..((((((((.(((...({((((......)))))[[......(((....}]])))...)))...))))))))))))))))))))))))).)....((((((((......))))))))....]....((.[[[[[[)).....)))......)).)).))).))................((....))....))......(..((((.....))))...........)).....))))).))).......((((((.(((....((......(((((.(...(.....((((....))))......)..).)))))...)).))).)))))).[((((........))))((((((....(((((((((((((..((....((((.....))))....))...((....))...(((((...((((.......))))...)))))(((((......)))))...)))))))))))))..((((...((((((.....((((((((((.((((...(((((((....)))))))...)[))).....(((...(.((........)))..)))..).))))))))).(.((.......))...)..))))))......))))..((((((....((((......))))((((((((...(((.(((((.(((...(((....(((((((..((.(((((()))))).))..)))))))..)).)...))).))))))))......)))))).))..(((((.((((.....)))).)))))....(((......)))...(((((((...((([[[...(.((((((.....((........(((.(.((((((((.......(((((.((([..((.........).)..))).....(]..((......)).).)))))...)))))))).))))...........]]]))....))))))))))...)))))))((.(....((....))....).))....))))))((((((((..(((.....((((((((....))))))))...))).)))))).)).....))))))(......((......((((((.......))))))((((....((((..((..(((((((....(.....)..))))))....(([.((...((((((.((.....))..))))))....))...(((.(........).)))))((((((((.....(((....)))...(((((((((....(((((((((...((((((((((((.{.{)))))))((..((((.(..((((((......((.....))......))))))...)))))...).)((((((....)))))).)))))....)))))))))(...).....)))))))))......))))))))...].))).....((......)).))))(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((((((......)))))))))))))(...).......(((((((.(.].((.........))....((((((.....(((....))).......))))))..}.(((.(((..(((((((..(....((((......)))).......))))))..)))))(.(((.........))).).........(.(......).(((((.......)))))..).......)))....)..))))))).)..))).)))))))).)))))).....).{...(((((.....]}.)))))..((((((((.((..((......((((.((((((..(((((.(((((((((.((((((((.((((.((.(.........(((((..(((.......(.(.(((.....))))..)...)))............)))))).)).)))).))))))))...((((((....))))))....)))))))))..)))))..(((......[)).)(((((...........].)))))([((...((.((((.(.(((((.........)))))...).((][.[[[))....)))).))...((((((((...........)))))))).(((....))).))]]].].....(..((.(((((..]]]]]])))))))..)....).....))))..))))))......((((....((((((...((.......))...)))))).....)).).)......(.((.((.(((..(((((((((......))))))..)))..((((.....))))......))).)..)...))..).....(((((((....))).))))....))...))))))))))....(((((((...((((..(((((((......(....).....)))))))(((((...(.((...((((.((.((}.}.)).))...)))).[.)).).))))).(((((...((((.............))))...))))))))).......))))))).((())).((((((.((((.......)))).....(((.(((((((......((((..(((......)))..)))).....)))]))))..)))...))))).)... Cryo-EM Structures and Translocation Mechanism of Crenarchaeota Ribosome; 23S rRNA 8hky A16S 1493 4.45 RF01959,RF00177,RF01960,RF02542 URS00009F3A78_330779 37604686 0003735 0005840 330779 auuccgguugauccugccggacccgaccgcuaucgggguagggauaagccaugggagucuuacacucccggguaagggaguguggcggacggcugaguaacacguggcuaaccuacccucgggacggggauaaccccgggaaacuggggauaauccccgauagggaaggaguccuggaaugguuccuucccuaaagggcuauaggcuauuucccguuuguagccgcccgaggauggggcuacggcccaucaggcugucggugggguaaaggcccaccgaaccuauaacggguaggggccguggaagcgggagccuccaguugggcacugagacaagggcccaggcccuacggggcgcaccaggcgcgaaacguccccaaugcgcgaaagcgugagggcgcuaccccgagugccuccgcaggaggcuuuuccccgcucuaaaaaggcgggggaauaagcggggggcaagucuggugucagccgccgcgguaauaccagcuccgcgaguggucggggugauuacugggccuaaagcgccuguagccggcccaccaagucgccccuuaaaguccccggcucaaccggggaacugggggcgauacuggugggcuagggggcgggagaggcgggggguacucccggaguaggggcgaaauccuuagauaccgggaggaccaccaguggcggaagcgccccgcuagaacgcgcccgacggugagaggcgaaagccggggcagcaaacgggauuagauaccccgguagucccggcuguaaacgaugcgggcuaggugucgaguaggcuuagagccuacucggugccgcagggaagccguuaagcccgccgccuggggaguacggucgcaagacugaaacuuaaaggaauuggcgggggagcaccacaagggguggaaccugcggcucaauuggagucaacgccuggaaucuuaccgggggagaccgcaguaugacggccaggcuaacgaccuugccugacucgcggagaggaggugcauggccgucgccagcucguguugugaaauguccgguuaaguccggcaacgagcgagacccccaccccuaguugguauucuggacuccgguccagaaccacacuagggggacugccggcguaagccggaggaaggagggggccacggcaggucagcaugccccgaaacucccgggccgcacgcggguuacaauggcagggacaacgggaugcuaccucgaaagggggagccaauccuuaaacccugccgcaguugggaucgagggcugaaacccgcccucgugaacgaggaaucccuaguaaccgcgggucaacaacccgcggugaauacgucccugcuccuugcacacaccgcccgucgcuccacccgagcgagaaaggggugaggucccuugcgauaagugggggaucgaacuccuuucccgcgaggggggagaagucguaacaagguagccguaggggaaccugcggcuggaucaccucau ...<<<<..[.((((.>>>>.<<<<<<<<......<<<.<<......<<<.<<<..<<<....<<<<<<......>>>>>>..>>>......<<<.......<<.<<<<..<<...<<<<<<<..<<<<....<<<<<......>>>>>.....>>>>....<<<<<<<<..<<......>>.>>>>>>>>......<<<<<<..............>>>>>>..>>>>>>>..>>>>>>.>>.<<<....<<...<<<<<<<<.......>>>>>>>>.>>......>>>..<<<<<<<<....>>>>...>>>>>>>.<<<<<............>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>..>>>....<<<<<<...>>>>>>...<<<<<<<.........>>>>>>.>....<<<<<((......<<<<......<..))>........>>>>.>>>>>...>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<......<<<<<<<.....>>>>>>>....>>>>>>>..>>>>>>>>>...<<<<<<.....<<<<<<<<<<.<<<<<<<....<<<......>>>.......>>>>>>>.>>>.......<<....>>.>>>>>>>....>>>.>>>...>>>...>>>>...<<<<<<<...<<...<<<<.........>>>>...>>>>>>>>>.........<<<<<<..<<<<<<<<<<<<<<.....>>>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<.<<<<<<.<<<<.<<<<<<......<<........>>..........<<<<<.....<<<<........<<<.<<<.......>>>.>>>......>>>>...<<.<<<..<<<<<<<<.....<<<<<<.<<....>>...<<<<......>>>>..>>>>>>....<<<<<.<<<<<<<.<<.......<<<<....>>>>.......>>>>>>>>>.....<<<<<....>>>>>........>>>>>.....>>.>>>...>>>>>>>>......>>>>>...>>.>>>>.>>>.>...<<.<<<<......<<..<<..<<<......>>>..>>....>>.....>>>>.>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<.<<<<<<<<<..<<<<<<<.<<.....>>.>>>>>>>..>>>>>>>>>.>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ ...((((..[.[[[..)))).(((((((.(.....(((.(((..[..(((.(((..(((..((((((((......)))))))))))......(((.......(((.((...((...(((((((..((((....((((.(....).)))).....))))....((((((....((......))...))))))....(.(((((((............)))))))).)))))))..)).)).))).(((....((...((((((((.......)))))))).))......)))..(.((((((....))))...)).)))).(((((............))))).((((....))))...)))))).)...].(.(((...(.(((....)))..))))).))..)))....((((((...))))))...(((((((.........)))))).)....((((([[......((((.....((..]])).......)))).)))))..).)))))))..........((([[...(.((((...(((.(.(((((.(((((((((......(((((((.....)))))))....)))))))..))))))).)..(((((((......((((((((..(((((((....((........)).......)))))))..)).......((....)).)))))).....))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((..((((((((((.....))))))))))..))...((..]])).....))))))))))..((.......(((....))).....))....]]].]((((...((((((..((.((((((..((((.(((((......((........))..........(((((.(...((((.(......(((.(((.......))).)))...)..))))...((.((....((.(((.(....((((((.((....))...((((......))))..))))))....(((((.(((((((.((.......((((....)))).....)..))))))).).(..(((((....))))).....)..)))))....).).))....))..))))....).)))))...)).))).)))).(...(((((((.....(.(..((..((.(....).))..))....)).....)))))))......(....(((((((........)))))))....)..)..))))))....((((((((.......))))))))......))...))))))..)).))..(.(..((.(.((((.(((..(((.(((((((((..(.((((...(.....)...)))).)..))))))))).)))..))).))))..).))...)..)..(((((((((....)))))))))}........... Cryo-EM Structures and Translocation Mechanism of Crenarchaeota Ribosome; 16S rRNA 8hky AATN 76 4.45 RF00005 URS00005AA258_330779 37604686 0030533 0006412 330779 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<...<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>.>>>>>>.... ((((((...((((........)))).(((((.......))))).....((.((.......)).)).)))))).... Cryo-EM Structures and Translocation Mechanism of Crenarchaeota Ribosome; tRNA (76-MER) 8hky A5S 122 4.45 RF00001 URS000056704D_330779 37604686 0003735 0005840 330779 ugcccacccggucauagugagcggguaacacccggacucguuucgaacccggaaguuaagccgcucacgucagaggggccgugggauccgagagggcccgcagccucucugagcugggaugg ......<<<<.......<<<<<<<.....<<<<<...............>>>..>>....>>>>>>>...<<<<<<<<...<<<<..<<....>>.>>>>...>>>>>>>>...>>>>.... ...(..(((..(....((((((((.......((((.............))))........)))))))).((((((((((.(((((..((....)).))))).)))))))))))..)))..). Cryo-EM Structures and Translocation Mechanism of Crenarchaeota Ribosome; 5S rRNA (122-MER) 8hky APTN 76 4.45 RF00005 URS00005AA258_330779 37604686 0030533 0006412 330779 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<...<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>.>>>>>>.... ((((((...((((.....[..)))).(((((.......))))).....(((((..]....))))).)))))).... Cryo-EM Structures and Translocation Mechanism of Crenarchaeota Ribosome; tRNA (76-MER) 8hky AETN 76 4.45 RF00005 URS00005AA258_330779 37604686 0030533 0006412 330779 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<...<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>.>>>>>>.... ((((((...((((.....[..)))).(((((.......))))).....((.((..]....)).)).)))))).... Cryo-EM Structures and Translocation Mechanism of Crenarchaeota Ribosome; tRNA (76-MER) 8hkz A23S 2996 4.78 RF02540,RF02541,RF02543,RF00002 URS0000759EE6_330779 37604686 0003735 0005840 330779 aagccucccgguggauggcucggcucgggcaccgaagaagggcgcggcaagcagcgaaaugcucgggugaggcgcaagcagccguugaccccgagguccccuaaugggauauccugccggguuuccggcgcccgguuuauaacugggugggaaccccccgaacggaaacaucuuaguagggggaggaaaagaaaucaauugagauccccugaguaggggcgaccgaaagggggacagcccaaacuaaaccugccgaugauaagucgguggggaugugguguuacgaccucuagccugagguugaccucggcuuuccuaaccuaucuagccgaacuccccuggaacggggggccauagagggugaaagccccguaggcuaaagauagguggaaaguggcuagagguagaguaccauccccugguuugggggugggaaguuaggggacacgugccucuaaggcuaaauaugucccgagaccgauagcaaacuaaguaccgugagggaaagcugaaaagaaccccggaagggggagugcaaagagccugaaaccgggugguuauacaggguguggcucgaaagaagugaacccuuccgaaggaaaggggcgcaagcccuuaguacgaggaagggcgaucggggucacgccuuucgucuugaaacacgggccggggaguucacaucaguggcgagcuuaaggagauuaucuccgaaggcauagggaaaccaagugcccgcagccuaguuucuaggcgaggggcagggucugucagggccugaagccacugaugugaggcuagaaaccgggcgaucuaguccggggcaggcugaaggugggggaaaccccacuggagggccgaauagggguucugacgugcaauucguucccuugaccucggacuaggggcaaaagaccaaucuagcccggugauagcuaguuccccccgaaaugcguccuagcgcagccucccuaaaggcagcucgcgggguagagugacagaucgggggcuccaggcgccuggggcuuccggucuaacuccgaacccacgagcgccgaagaaggggggagugggucacucggcguaagguuggguggcaaaaggggaacaacccagaccuggguuaaggccccaaagucccggcuaagugccaacgaaaaggcgucuccagccuuagacagcgggaaggugggcccagcagcagccauccucuaaggagugcguaacagcucacccgccgaggcuggaggcccuaaagauuggucggggcucaagccgggcgccgagacccaggagggggucucuacugagauccucugguaggggggcgcugugaugggguagaaggugggucgugagauccacuggacccgucacaggugcagaucccggcgguaguaacagcgaaggggggugagaaucccccucgccggaagggcaaggguuucccggcaacguucgucagccgggaguuagccgccuaagguagggccuaauagguaccuaccgaaagggaaagggguuaacauuccccugccucccggguaggugcgguaacgcaagccagacuccugacggauugggguagggagaguaggaccaccguccuacccaagcacucaagcccuuggagagccguaacggugagaagagggcgaaggugugaugggccuuccguuaggaggguucuccugaucccuaguccccaugaaaagggagucuggaacgaucccgggagaccguaccuagaaccgacacuggugcccgggugagaagcccaaggcgucugagggguaacccaggcuagggaacucggcaaauuagccccguaacuucgggagaaggggugccuaucgugguuuaacaaagccacgauaggucgcagugaccagagggaccugacuguuuaauaaaaacauagguccccgcuagcccgaaaggguguguacgggggcuaaauccuggccacuggugguugaaauccggguucaaccgggcgaagccccaccgaaggccggggguaacucugacccucuuaagguagccaaaugccuugccggguaaguuccggcgcgcaugaauggaucaacgcggucccuacugucccagccuggggccucgugaacgcccugagccggugcacaguccggcaucucccuacaccgagagaagaccccguggagcuucaccgcagccuggcguugucccucgggcguuuaugcguagaguaggugggaggggucgaaccuguccuuucgggggcaggggacccgaaagugaaacaccacccauggacgcucgagggacuaaccucucgaaagagaggaacaacgucaggugggcgguucggcuggggcggcacucccgcgaaaagauaacacgggagcccaaaggucggcucaggcgguacagaacgccgccguagagcgcaagggcaaaagccggccugacgugacccuuccaaguacggggucacgacgcgaaagcggggccuagcgaacgcucgugcccccacacgugggggccgggcaugacagaaaaguuaccccggggauaacagggucgucgcgggcgagagcucacaucgaccccgcgguuugcuacaucgaugucggcucuucccacccuggaggugcagcugccuccaaggguagggcugcccgcccguuaaaggggagcgugagcuggguuuagaccgucgcgagacaggucggacucuaaggguagggagugcggaccgcuugaggggaaggaaccccuaguacgagaggaacaggguuccggggccuccaguuuaccgguuguccgguagggcaaugccgggcagccgcgcccugagggguaaccgcugaaagcaucuaagcgggaaccccuccccuaaaagaggcggucaggcgccggggccuuccccuagaagaggggguugaugggguggggauguaagcuccaagguuguaagaccgaggaguuuaguccgccacucccaaucaggcuccccc ..<<<.<<<<<<.....<<..<<<<<<<<<<<<.....<<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>>...<<<....>>><<<<<....>>>>><<<<<<<.....>>>>>>>>>...<<<<<<....<<<....>>>.....>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..[.....<<<...<<<<<<<<<.....>>>>>>>>>.....>>>......<<<<<<<<<<<<<<<<..>>>>>><<<<<<<..<<<<<<<<.<<<.....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>>>>>>>>>>>>......<<<<<<<<......>>>>>>>>......<<<<<.<<<<<<>>>>>....]......>>.>>>>>>.>>................<<....>>....>>.........<<<<.....>>>>.................>>>>>>.>>>.......<<<<<<<<<<....<<......<<<<<<<...<....<<<<<....>>>>>.....>..>>>>>>>...>>.>>>>>>>>>>..<<<..........>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>...<<<<<...<<<<.......>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>..<<<<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<<<....<<........>>..>>>>>...>>>>>>>>>...<<.......>>......>>>>>>......>>>>..<<<<<<....<<<<<....>>>>><<<<<<<<...<<<.<<<<<.<<<...<<<......<.<<<<<<<<<<<<<<>>>>>>>>>>>>>>.>....>>.>...>>>.>>>>>>>>......>>>>>>.>>..<<<<<.<<<<.....>>>>.>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<........<<<.<<<<<<<<<<.......<<<<<.<<....<............>...>>.........<<......>>...>>>>>...>>>>>>>>>>>>>...........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<<<......>>>>>>>>>....>>>>>><<<<<<<<<.<<<.....<<<<<<<<....>>>>>>>>...>>>>>>>>>>.>>.....>>>>>><......<<......<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<....<.....>..>>>>>>....<<.(<<...<<<<<<<<<.....>>>.>>>>>>....>>...<<<<<........>>>>>>><<<<<<<<.....<<<....>>>...<<<<<<<<<<...<<<<<<<<<..<<<<<<<<<<<<......>>>>>><<..<<<<<...<<<<<<.....<<<<...>>>>.....>>>>>>...>>>>>...>><<<<<<<....>>>>>>>>>>>>>...>>>>>>>>>.........>>>>>>>>>>......>>>>>>>>.)....>>.....<<......>>>>>>><<<.......>>>..>>>>...<<<<.....<<<<<<<<.<<...............<<<<<....<<..>>.....>>>>><<<<<<<<<<<<<......>>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<....>>>>......>>>>>>>..<<<<.<<<..<<<<<<<......<<<<<......>>>>>.......>>>>>..>>>>>.<<<<.........>>>>.........<...........<<<<<<.....>>>>>>.....>....>>>>...>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.[[..[[......<<<<.[[<<<<..<<<<<.<<<<<<<<<.<<<<<<<<<<<<<<<<.<.........<<.<<....<.........<.<<.......>>>......>..............>>.>>>.>>>>>>>>>>>>>>>>...<<<<<<....>>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<.............>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<..>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<..<<<<<<<...<<.......>>...>>>>>>>...>>>.>........<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>......>>>.>.....<<<<<<<....>>>.>>>>....]]...]]>>>>>>>>....<<<<<<<..<<<<<..<<<<<<<.................>>>>>>><<<<<...<.<<...<<<<<<<<<<....>>>>>..>>>>>...>>.>.>>>>>.<<<<<...<<<<<...........>>>>>...>>>>>>>>>>......>>>>>>>.<<<>>><<<<<<<<<<<<.......>>>>>....<<<<<<<<<<<<....<<<<<..<<<<....>>>>..>>>>>...>>>>.>>>>>.>>>...>>>>>>>... ...((.(((((.....(((..(((((.((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))(((((....))))).((((((.....)))))).))...((((((....((...[..)).....))))).).........((....))...(((((.....((.]...))....)))))...((.(...(...(((..(((((.....)))))..))....).)....[..((((((((((((((((..)))))).((((((...(((((((.(((...({((((......)))))[[......(((....}]])))...)))...))))))).)))))).)))))))))).)....(((.((((......)))).)))....]....((.[[[[[[))......))......)).)).))).))................((....))....))......(..((((.....))))...........)).....))))).))........(..(((.(((....((......(((((.(...(.....((((....))))......)..).)))))...)).))).)))..).[.(((........))).((((((..(.(((((((((((((..((....((((.....))))....))...((....))...(((((...((((.......))))...)))))(((.((....)).)))...)))))))))))))..((((...((((((.....((((((((((.(((.....((((((....)))))).....[)))....((((...(.((........)))..)))).).))))))))).(.((.......))...)..))))))......))))).((((((....((((......))))(((.((((...(((.(((((.(((...(((....(((((((..((.(((((()))))).))..)))))))..)).)...))).))))))))......)))).).))..(.(((.((((.....)))).))).)....(((......)))...(((((((...((([[[...(.((((((.....((........(((.(.((((((((.......(((((..(([..((.........).)..))......(]..((......)).).)))))...)))))))).))))...........]]]))....))))))))))...)))))))((.(((..(......)..))).))....))))))((((((((..(((......((((.((....)).))))....))).)))))).)).....))))))(......((......((((((.......))))))((((....((((..((..(((((((....(.....)..))))))....(([[((...((((((.((.....))..))))))....))...(((............)))))((((((((.....(((....)))...(((((((((....(((.(((((..(((((((((((((.{.{)))))))((..((((.(..(((((.......((.....)).......)))))...)))))...).)((.(((....))).)).))))))...))))).)))(...).....)))))))))......)))))))).].].))).....((......)).))))(((.......)))..))))...((((.....((((((((.((..(....(........((((....(.{..).....))))..((((((((((((......)))))))))))).(...).......(((((((.(.].((.........))....(.((((....((((....))))......)))).)..}.(((.(((..(((((((..(...(((((......)))))......))))))..)))))(.(((.........))).).........(.(......).(((((.......)))))..).......)))....)..))))))).)..))).)))))))).)))))).....).{...(((((.....]}.)))))..((((((((.((..((......((((.((((((..(((((..((((((((.((((((((.((((..(.(.........(((((..(((.......(.(.((.......)))..)...)))............)))))).)..)))).))))))))...((((((....))))))....))))))))...)))))..(((......[)).)(((((...........].)))))([((...((.((((.(.(((((.........)))))...).((][.[[[))....)))).))...((((((((...........)))))))).(((....))).))]]].].....(..((.(((((..]]]]]])))))))..)....).....))))..))))))......((((....((((((...((.......))...)))))).....)).).)......(.((.((.(((..((.(((((........)))))...))..((((.....))))......))).)..)...))..).....(((((((....))).))))....))...))))))))))....((((((....((((..((((((.(.....(....).....))))))).((((...(.((...((((.(((((}.}.)))))...)))).[.)).).))))..(((((...((((.............))))...)))))))))........)))))).((())).(.((((.((((.......)))).....(((.(((((((.....(((((..(((......)))..)))))....)))]))))..)))...))))..)... Cryo-EM Structures and Translocation Mechanism of Crenarchaeota Ribosome; 23S rRNA (2996-MER) 8hkz A16S 1493 4.78 RF01959,RF00177,RF01960,RF02542 URS00009F3A78_330779 37604686 0003735 0005840 330779 auuccgguugauccugccggacccgaccgcuaucgggguagggauaagccaugggagucuuacacucccggguaagggaguguggcggacggcugaguaacacguggcuaaccuacccucgggacggggauaaccccgggaaacuggggauaauccccgauagggaaggaguccuggaaugguuccuucccuaaagggcuauaggcuauuucccguuuguagccgcccgaggauggggcuacggcccaucaggcugucggugggguaaaggcccaccgaaccuauaacggguaggggccguggaagcgggagccuccaguugggcacugagacaagggcccaggcccuacggggcgcaccaggcgcgaaacguccccaaugcgcgaaagcgugagggcgcuaccccgagugccuccgcaggaggcuuuuccccgcucuaaaaaggcgggggaauaagcggggggcaagucuggugucagccgccgcgguaauaccagcuccgcgaguggucggggugauuacugggccuaaagcgccuguagccggcccaccaagucgccccuuaaaguccccggcucaaccggggaacugggggcgauacuggugggcuagggggcgggagaggcgggggguacucccggaguaggggcgaaauccuuagauaccgggaggaccaccaguggcggaagcgccccgcuagaacgcgcccgacggugagaggcgaaagccggggcagcaaacgggauuagauaccccgguagucccggcuguaaacgaugcgggcuaggugucgaguaggcuuagagccuacucggugccgcagggaagccguuaagcccgccgccuggggaguacggucgcaagacugaaacuuaaaggaauuggcgggggagcaccacaagggguggaaccugcggcucaauuggagucaacgccuggaaucuuaccgggggagaccgcaguaugacggccaggcuaacgaccuugccugacucgcggagaggaggugcauggccgucgccagcucguguugugaaauguccgguuaaguccggcaacgagcgagacccccaccccuaguugguauucuggacuccgguccagaaccacacuagggggacugccggcguaagccggaggaaggagggggccacggcaggucagcaugccccgaaacucccgggccgcacgcggguuacaauggcagggacaacgggaugcuaccucgaaagggggagccaauccuuaaacccugccgcaguugggaucgagggcugaaacccgcccucgugaacgaggaaucccuaguaaccgcgggucaacaacccgcggugaauacgucccugcuccuugcacacaccgcccgucgcuccacccgagcgagaaaggggugaggucccuugcgauaagugggggaucgaacuccuuucccgcgaggggggagaagucguaacaagguagccguaggggaaccugcggcuggaucaccucau ...<<<<<.[.((((>>>>>.<<<<<<<<<.....<<<.<<......<<<.<<<..<<<..<<<<<<<<......>>>>>>>>>>>......<<........<<<<<<...<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<<<<..<<......>>.>>>>>>>>.....<<<<<<<..............>>>>>>>.>>>>>>>..>>.>>>>>>.<<<....<<...<<<<<<<<.......>>>>>>>>.>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<............>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>..>>>....<<<<<<...>>>>>>...<<<<<<<.........>>>>>>>.....<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<......<<<<<<<.....>>>>>>>....>>>>>>>..>>>>>>>>>...<<<<<<.....<<<<<<<<<<.<<<<<<<....<<<......>>>.......>>>>>>>.>>>.......<<....>>.>>>>>>>....>>>.>>>...>>>...>>>>...<<<<<<<...<<...<<<<.........>>>>...>>>>>>>>>.........<<<<<<..<<<<<<<<<<<<<<.....>>>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<.<<<<<<.<<<<<<<<<<<......<<........>>..........<<<<<.....<<<<<.......<<<.<<<.......>>>.>>>....>.>>>>...<<.<<<..<<<<<<<<.....<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>....<<<<<.<<<<<<<..........<<<<....>>>>.........>>>>>>.>....<<<<<....>>>>>........>>>>>.....>>.>>>...>>>>>>>>......>>>>>...>>.>>>>>>>>.>...<<.<<<<.....<<...<<..<<<<....>>>>..>>....>>.....>>>>.>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<.<<<<<<<<<..<<<<<<<<<<.....>>>>>>>>>>..>>>>>>>>>.>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ ...((((....[[[..)))).(((((((.(.....(((.(((..[..(((.(((..(((..(.((((((......)))))).))))......(((.......(((.(....((...(((((((.(((((....((((.(....).)))).....)))))...((((((((..((......)).))))))))....(.((((.(..............).))))).)))))))..))..).))).(((.<..((...((((((((.......)))))))).))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).)...].(.(((...(.(((....)))..))))).))..)))....((((((...))))))....((((((.........))))))......((((.[[......((((.....((..]])).......))))..))))..).)))))))..........((([[...(.((((....((.(.(((((.(((((((((......(((((((.....)))))))....)))))))..))))))).)..(((((((.....((((((((((.(((((((....((........)).......))))))).))).......((....)).)))))))....))).)))..)))....))))....((((((....(...((((.........))))...).))))))......{...((((((..((..((((((((((.....))))))))))..))...((..]])).....))))))))))...(....>..(((....))).....).....]]]..((((...((((((..((.((((.(..((((.(((((......((........))..........(((((.(...((((((......(((.(((.......))).)))...)).))))...((.(((...((.(((.(....((((((.((....))...((((......))))..))))))....(((((.(((((((.((......(((((....)))).)..)...))))))).).(..(((((....))))).....)..)))))....).).))....)).)))))....).)))))...)).))).)))).(...(((((((.....(.(..((..((.(....).))..))....)).....)))))))......(....(((((((........)))))))....)..)..).))))....((((((((.......))))))))......))...))))))..)).))..(.(..((.(.((((.(((..(((.((((((.((..(.((((...(.....)...)))).)..)).)))))).)))..))).))))..).))...)..)..(((((((((....)))))))))}........... Cryo-EM Structures and Translocation Mechanism of Crenarchaeota Ribosome; 16S rRNA (1493-MER) 8hkz A5S 122 4.78 RF00001 URS000056704D_330779 37604686 0003735 0005840 330779 ugcccacccggucauagugagcggguaacacccggacucguuucgaacccggaaguuaagccgcucacgucagaggggccgugggauccgagagggcccgcagccucucugagcugggaugg ......<<.<......<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>>>.<<<<<.<<<<.<<<<<..<<....>>.>>>>>.>>>>.>>>>>..>.>>.... ..((..(((((.....((((((((.....((((((...(.....)...))))..))....)))))))).(((((.((((.(.(((..((....)).))).).)))).))))).)))))..)) Cryo-EM Structures and Translocation Mechanism of Crenarchaeota Ribosome; 5S rRNA (122-MER) 8hkz APTN 76 4.78 RF00005 URS00005AA258_330779 37604686 0030533 0006412 330779 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<...<<<<........>>>><<<<<<<.....>>>>>>.>...<<<<<.......>>>>>.>>>>>>.... ((((((...((((.....[..)))).(((((.......))))).....((.((..]....)).)).)))))).... Cryo-EM Structures and Translocation Mechanism of Crenarchaeota Ribosome; tRNA (76-MER) 8hkz AETN 76 4.78 RF00005 URS00005AA258_330779 37604686 0030533 0006412 330779 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<...<<<<........>>>>.<<<<<<.....>>>>>>......<<<<.......>>>>..>>>>>>.... ((((((...((((.....[..)))).(((((.......))))).....(((((..]....))))).)))))).... Cryo-EM Structures and Translocation Mechanism of Crenarchaeota Ribosome; tRNA (76-MER) 8hl1 A16S 1493 3.93 RF01959,RF00177,RF01960,RF02542 URS00008A1CEE_330779 37604686 0003735 0005840 330779 auuccgguugauccugccggacccgaccgcuaucgggguagggauaagccaugggagucuuacacucccggguaagggaguguggcggacggcugaguaacacguggcuaaccuacccucgggacggggauaaccccgggaaacuggggauaauccccgauagggaaggaguccuggaaugguuccuucccuaaagggcuauaggcuauuucccguuuguagccgcccgaggauggggcuacggcccaucaggcugucggugggguaaaggcccaccgaaccuauaacggguaggggccguggaagcgggagccuccaguugggcacugagacaagggcccaggcccuacggggcgcaccaggcgcgaaacguccccaaugcgcgaaagcgugagggcgcuaccccgagugccuccgcaggaggcuuuuccccgcucuaaaaaggcgggggaauaagcggggggcaagucuggugucagccgccgcgguaauaccagcuccgcgaguggucggggugauuacugggccuaaagcgccuguagccggcccaccaagucgccccuuaaaguccccggcucaaccggggaacugggggcgauacuggugggcuagggggcgggagaggcgggggguacucccggaguaggggcgaaauccuuagauaccgggaggaccaccaguggcggaagcgccccgcuagaacgcgcccgacggugagaggcgaaagccggggcagcaaacgggauuagauaccccgguagucccggcuguaaacgaugcgggcuaggugucgaguaggcuuagagccuacucggugccgcagggaagccguuaagcccgccgccuggggaguacggucgcaagacugaaacuuaaaggaauuggcgggggagcaccacaagggguggaaccugcggcucaauuggagucaacgccuggaaucuuaccgggggagaccgcaguaugacggccaggcuaacgaccuugccugacucgcggagaggaggugcauggccgucgccagcucguguugugaaauguccgguuaaguccggcaacgagcgagacccccaccccuaguugguauucuggacuccgguccagaaccacacuagggggacugccggcguaagccggaggaaggagggggccacggcaggucagcaugccccgaaacucccgggccgcacgcggguuacaauggcagggacaacgggaugcuaccucgaaagggggagccaauccuuaaacccugccgcaguugggaucgagggcugaaacccgcccucgugaacgaggaaucccuaguaaccgcgggucaacaacccgcggugaauacgucccugcuccuugcacacaccgcccgucgcuccacccgagcgagaaaggggugaggucccuugcgauaagugggggaucgaacuccuuucccgcgaggggggagaagucguaacaagguagccguaggggaaccugcggcuggaucaccucau ...<<<<<.[.((((>>>>>.<<<<<<<<<.....<<<.<<......<<<.<<<..<<<..<<<<<<<<......>>>>>>>>>>>......<<........<<<<<<<..<<...<<<<<<<.<<<<<...<<<<<<......>>>>>.>...>>>>>..<<<<<<<<<<.<<......>>>>>>>>>>>>...<<.<<<<<<............>>>>>>>>.>>>>>>>..>>>>>>>>>.<<<....<<...<<<<<<<<.......>>>>>>>>.>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<............>>>>>.<<<<<..>>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>..>>>....<<<<<<...>>>>>>...<<<<<<<.........>>>>>>>.....<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<......<<<<<<<.....>>>>>>>....>>>>>>>..>>>>>>>>>...<<<<<<.....<<<<<<<<<..<<<<<<<..<.<<<......>>>......>>>>>>>>..>>.......<<....>>.>>>>>>>....>>>.>>>...>>>...>>>>...<<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>>.........<<<<<<..<<<<<<<<<<<<<<.....>>>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<.<<<<<<..<<<<<<<<.<......<<........>>..........<<<<<.<...<<<<<<......<<<.<<<.......>>>.>>>...>>.>>>>...<<.<<<..<<<<<<<<.....<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>....<<<<<.<<<<<<<.<.....<<<<<<<....>>>>>>>.....>>>>>>>>.....<<<<<....>>>>>........>>>>>.....>>.>>>...>>>>>>>>.....>>>>>>...>..>>>>>>>>.....<<<<<<<.....<<...<<..<<<......>>>..>>....>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<.<<<<<<<<<..<<<<<<<<<<.....>>>>>>>>>>..>>>>>>>>>.>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ ...((((..[.[[[..)))).(((((((((.....(((.(((..[..(((.(((..(((..((((((((......)))))))))))......(((.......(((.(((..((...(((((((.(((((....((((((....)))))).....)))))...((((((((..((......)).))))))))....(.((((.(..............).))))).)))))))..))))).))).(((....((...((((((((.......)))))))).))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).)...].(.(((...(((((....)))).))))).))..)))....((((((...))))))....((((((.........))))))......((((([[......((((.....((..]])).......)))).)))))..)))))))))..........((([[...(.((((...(((.(((((((.(((((((((......(((((((.....)))))))....)))))))..)))))))))..(((((((.....(((((((((..(((((((....((........)).......)))))))..)).......((....)).)))))))....))).)))..))))...))))....((((((....(...((((.........))))...).))))))......{...((((((..(((.((((((((((.....)))))))))).)))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((..((.((((((..((((((((((......((........))..........((((.((...((((((......(((.(((.......))).)))...)).))))...((.((....((((((.(....((((((.((....))...((((......))))..))))))....(((((.(((((((.((.......((((....)))).....)..))))))).).(..(((((....))))).....)..)))))....).).)))...))..))))....).)))))...)).)))))))).(...(((((((.....(.(..((..((((....))))..))....)).....)))))))......(....(((((((........)))))))....)..)..))))))....((((((((.......))))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((.(((((((((..((((((((((.....))))))))))..))))))))).)))..))).))))..).))...)..)..(((((((((....)))))))))}........... Cryo-EM Structures and Translocation Mechanism of Crenarchaeota Ribosome; 16s rRNA (1493-MER) 8hl1 A23S 2995 3.93 RF02540,RF02541,RF02543,RF00002 URS0000759EE6_330779 37604686 0003735 0005840 330779 aagccucccgguggauggcucggcucgggcaccgaagaagggcgcggcaagcagcgaaaugcucgggugaggcgcaagcagccguugaccccgagguccccuaaugggauauccugccggguuuccggcucccgguuuauaacugggugggaaccccccgaacggaaacaucuuaguagggggaggaaaagaaaucaauugagauccccugaguaggggcgaccgaaagggggacagcccaaacuaaaccugccgaugauaagucgguggggaugugguguuacgaccucuagccugagguugaccucggcuuuccuaaccuaucuagccgaacuccccuggaacggggggccauagagggugaaagccccguaggcuaaagauagguggaaaguggcuagagguagaguaccauccccugguuugggggugggaaguuaggggacacgugccucuaaggcuaaauaugucccgagaccgauagcaaacuaaguaccgugagggaaagcugaaaagaaccccggaagggggagugcaaagagccugaaaccgggugguuauacaggguguggcucgaaagaagugaacccuuccgaaggaaaggggcgcaagcccuuaguacgaggaagggcgaucggggucacgccuuucgucuugaaacacgggccggggaguucacaucaguggcgagcuuaaggagauuaucuccgaaggcauagggaaaccaagugcccgcagccuaguuucuaggcgaggggcagggucugucagggccugaagccacugaugugaggcuagaaaccgggcgaucuaguccggggcaggcugaaggugggggaaaccccacuggagggccgaauagggguucugacgugcaauucguucccuugaccucggacuaggggcaaaagaccaaucuagcccggugauagcuaguuccccccgaaaugcguccuagcgcagccucccuaaaggcagcucgcgggguagagugacagaucgggggcuccaggcgccuggggcuuccggucuaacuccgaacccacgagcgccgaagaaggggggagugggucacucggcguaagguuggguggcaaaaggggaacaacccagaccuggguuaaggccccaaagucccggcuaagugccaacgaaaaggcgucuccagccuuagacagcgggaaggugggcccagcagcagccauccucuaaggagugcguaacagcucacccgccgaggcuggaggcccuaaagauuggucggggcucaagccgggcgccgagacccaggagggggucuacuagagauccucugguaggggggcgcugugaugggguagaaggugggucgugagauccacuggacccgucacaggugcagaucccggcgguaguaacagcgaaggggggugagaaucccccucgccggaagggcaaggguuucccggcaacguucgucagccgggaguuagccgccuaagguagggccuaauagguaccuaccgaaagggaaagggguuaacauuccccugccucccggguaggugcgguaacgcaagccagacuccugacggauugggguagggagaguaggaccaccguccuacccaagcacucaagcccuuggagagccguaacggugagaagagggcgaaggugugaugggccuuccguuaggaggguucuccugaucccuaguccccaugaaaagggagucuggaacgaucccgggagaccguaccuagaaccgacacuggugcccgggugagaagcccaaggcgucugagggguaacccaggcuagggaacucggcaaauuagccccguaacuucgggagaaggggugccuaucgugguuuaacaaagccacgauaggucgcagugaccagagggaccugacuguuuaauaaaaacauagguccccgcuagcccgaaaggguguguacgggggcuaaauccuggccacuggugguugaaauccggguucaaccgggcgaagccccaccgaaggccggggguaacucugacccucuuaagguagccaaaugccuugccggguaaguuccggcgcgcaugaauggaucaacgcggucccuacugucccagccuggggccucgugaacgcccugagccggugcacaguccggcaucucccuacaccgagagaagaccccguggagcuucaccgcagccuggcguugucccucgggcguuuaugcguagaguaggugggaggggucgaaccuguccuuucgggggcaggggacccgaaagugaaacaccacccauggacgcucgagggacuaaccucucgaaagagaggaacaacgucaggugggcgguucggcuggggcggcacucccgcgaaaagauaacacgggagcccaaaggucggcucaggcgguacagaacgccgccguagagcgcaagggcaaaagccggccugacgugacccuuccaaguacggggucacgacgcgaaagcggggccuagcgaacgcucgugcccccacacgugggggccgggcaugacagaaaaguuaccccggggauaacagggucgucgcgggcgagagcucacaucgaccccgcgguuugcuacaucgaugucggcucuucccacccuggaggugcagcugccuccaaggguagggcugcccgcccguuaaaggggagcgugagcuggguuuagaccgucgcgagacaggucggacucuaaggguagggagugcggaccgcuugaggggaaggaaccccuaguacgagaggaacaggguuccggggccuccaguuuaccgguuguccgguagggcaaugccgggcagccgcgcccugagggguaaccgcugaaagcaucuaagcgggaaccccuccccuaaaagaggcggucaggcgccggggccuuccccuagaagaggggguugaugggguggggauguaagcuccaagguuguaagaccgaggaguuuaguccgccacucccaaucaggcuccccc <.<<<.<<<<<<....<<<..<<<<<<<<<<<<.....<<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>>...<<<....>>><<<<<<..>>>>>>.<<<<<<.....>>>>>>.>>...<<<<<<....<<......>>.....>>>>>.>.........<<<..>>>..<<<<<<.....<<.....>>....>>>>>>..<<<...<<<...<<<<<<<<<.....>>>>>>>>>.....>>>......<<<<<<<<<<<<<<<<..>>>>>><<<<<<<..<<<<<<<<.<<<.....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>>>>>>>>>>>>......<<<<<<<<......>>>>>>>>......<<<<<.((((((>>>>>..>>>......>>.>>>>>>.>>................<<....>>....>>.........<<<<.....>>>>............>....>>>>>>.>>>>......<<<<<<<<<<....<<......<<<<<<<...<....<<<<<....>>>>>.....>..>>>>>>>...>>.>>>>>>>>>>..<<<<........>>>><<<<<<...<<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>...<<<<<...<<<<.......>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>>.<<<<...<<<<<<.....<<<<<<<<<..<<<<...<<<<<<<....>>>>>>>...>.>>>....<<<<<....<<........>>..>>>>>...>>>>>>>>>...<<.......>>......>>>>>>......>>>>..<<<<<<....<<<<<....>>>>><<<<<<<<...<<<.<<<<<.<<<...<<<....<<<<<<<<<<<<<<<<<..>>>>>>>>>>>>>>>>>..>>.>...>>>.>>>>>>>>......>>>>>>.>>..<<<<<<.<<<.....>>>.>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<........<<<.<<<<<<<<<<.......<<<<<.<<.....<.........>.....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>...........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.<....>.>.>>>>>>....>>>>>><<<<<<<<<.<<<.....<<<<<<<<....>>>>>>>>...>>>>>>>>>>.>>.....>>>>>><......<<......<<<<<<.......>>>>>><<<<....<<<<<<<<...<<<<<<....<.....>..>>>>>>....<<.{<<...<<<<<<<<<.....>>>.>>>>>>....>>...<<<<<........>>>>>>><<<<<<<<.....<<<....>>>...<<<<<<<<<<...<<<<<<<<<..<<<<<<<<<<<<<.[[[>>>>>>><<..<<<<<...<<<<<<.....<<<<...>>>>.....>>>>>>...>>>>>...>><<<<<<<....>>>>>>>>>>>>>...>>>>>>>>>.........>>>>>>>>>>......>>>>>>>>.}....>>>....<<......>>>>>>><<<<.....>>>>..>>>>...<<<<.....<<<<<<<<.<<...............<<<<<....<....>.....>>>>><<<<<<<<<<<<<......>>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<....>>>>......>>>>>>>..<<<<.<<<..<<<<<<<......<<<<<......>>>>>.......>>>>>..>>>>>.<<<<<.......>>>>>.........<...........<<<<<<.....>>>>>>.....>....>>>>...>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<..<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<<<<<<<<<<<..........<<<<<..<<<......<.<<.<<<.....>>>>>.>...>>>............>>>>>.>>>>>>>>>>>>>>>>>...<<<<<<....>>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<.............>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<..))))))>>>>>>>>>>..........>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>..<<<<.....>>>>......>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>...>>>>>>>>>>....<<<<<<<..<<<<<..<<<<<<<.................>>>>>>><<<<<...<.<<...<<<<<<<<<<]]].>>>>>..>>>>>...>>.>.>>>>>.<<<<<...<<<<<...........>>>>>...>>>>>>>>>>......>>>>>>>.<<..>><<<<<<<<<<<<.......>>>>>....<<<<<<<<<<<<....<<<<<..<<<<....>>>>..>>>>>...>>>>.>>>>>.>>>...>>>>>>>... ...((.(((((.....(((..(((((.((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...))).....((....)).(((((....))))).(((.((.....)).))).))...((((((....((...[..)).....))))).).........((....))...(((((.....((.]...))....)))))...((.(...(...((((.((((.......)))).)))....).)....[..((((((((((.(((((()))))).(((((((...(((((((.(((...({((((......)))))[[......(((....}]])))...)))...))))))).))))))))))))))))).)....((((((((......))))))))....]...(((.[[[[[[))).....))......)).)).))).))................((....))....))......(..((((.....))))...........)).....))))).)).......(((((((((((....((......(((((.(...(.....((((....))))......)..).)))))...)).)))))))))))[((((........))))((((((..(.(((((((((((((..(((...((((.....))))...)))...((....))...(((((...((((.......))))...)))))(((((......)))))...)))))))))))))..((((...((((((.....((((((((((.((((....((((((....))))))....)[))).....(((...(.((........)))..)))..).))))))))).(.((.......))...)..))))))......))))).((((((....(((((....)))))((((((((...(((.(((((.(((...(((....(((((((((((((((((())))))))))))))))))..)).)...))).))))))))......)))))).))..((((((((((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((........(((.((((((((((.......(((((..(([..((.........).)..))......(]..((......)).).)))))...)))))))))))))...........]]]))....))))))))))...)))))))(((((((........).))))))....))))))(.(((((((.(((.....((((((((....))))))))...))))))))))..).....))))))(......((......((((((.......))))))((((....((((..((..(((((((....(.....)..))))))....((.[((...(((((((((.....))).))))))....))...(((............)))))((((((((.....(((....)))...(((((((((....(((((((((..(((((((((((((.{.{)))))))((..((((.(..((((((......((.....))......))))))...)))))...).)((((((....)))))).))))))...)))))))))(...).....)))))))))......)))))))).]...))).....((......)).))))((((.....))))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((((((......)))))))))))))(...).......(((((((((.].((.........))...(((((((....((((....))))......))))))).}.(((.(((..(((((((..(....((((......)))).......))))))..))))).((((.........)))).........((.(......).(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).)))))).....).{...(((((.....]}.)))))..((((((((.((..((......((((.((((((..(((((.(((((((((.((((((((.(((((((((.........(((((..(((......(..(.((.......)))..)...)))............)))))))))))))).))))))))...((((((....))))))....)))))))))..)))))..(((......[)).)(((((...........].)))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((..]]]]]]))))))))))....).....))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..)))..((((.....))))......)))))..)...))).).....(((((((....))).))))....))...))))))))))....(((((((...((((..(((((((......(....).....)))))))(((((...(.((...((((.(((((}.}.)))))...)))).[.)).).))))).(((((...((((.............))))...))))))))).......))))))).((())).((((((.((((.......)))).....(((.((((((((....(((((..(((......)))..)))))...))))]))))..)))...))))).)... Cryo-EM Structures and Translocation Mechanism of Crenarchaeota Ribosome; 23s rRNA (3000-MER) 8hl1 A5S 122 3.93 RF00001 URS000056704D_330779 37604686 0003735 0005840 330779 ugcccacccggucauagugagcggguaacacccggacucguuucgaacccggaaguuaagccgcucacgucagaggggccgugggauccgagagggcccgcagccucucugagcugggaugg ..<<..<<<<<.....<<<<<<<<.....<<<<<<.............>>>>..>>....>>>>>>>>.<<<<<<<<<<.<<<<<..<<....>>.>>>>>.>>>>>>>>>>.>>>>>..>> ..((..((((((....((((((((.....((((((...(.....)...))))..))....)))))))).((((((((((.(((((..((....)).))))).))))))))))))))))..)) Cryo-EM Structures and Translocation Mechanism of Crenarchaeota Ribosome; 5s rRNA (122-MER) 8hl1 APTN 76 3.93 RF00005 URS00005AA258_330779 37604686 0030533 0006412 330779 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<...<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>.>>>>>>.... ((((((...((((.....[..)))).(((((.......))))).....((.((..]....)).)).)))))).... Cryo-EM Structures and Translocation Mechanism of Crenarchaeota Ribosome; tRNA (76-MER) 8hl1 AETN 76 3.93 RF00005 URS00005AA258_330779 37604686 0030533 0006412 330779 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>......<<<<.......>>>>.>>>>>>>.... (((((((..((((........)))).(((((.......))))).....((.((.......)).))))))))).... Cryo-EM Structures and Translocation Mechanism of Crenarchaeota Ribosome; tRNA (76-MER) 8hl1 AMRN 13 3.93 37604686 330779 uuuuuuuuuuuuu ............. ............. Cryo-EM Structures and Translocation Mechanism of Crenarchaeota Ribosome; mRNA (5'-R(P*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*U)-3') 8hl2 A23S 2996 4.1 RF02540,RF02541,RF02543,RF00002 URS0000759EE6_330779 37604686 0003735 0005840 330779 aagccucccgguggauggcucggcucgggcaccgaagaagggcgcggcaagcagcgaaaugcucgggugaggcgcaagcagccguugaccccgagguccccuaaugggauauccugccggguuuccggcucccgguuuauaacugggugggaaccccccgaacggaaacaucuuaguagggggaggaaaagaaaucaauugagauccccugaguaggggcgaccgaaagggggacagcccaaacuaaaccugccgaugauaagucgguggggaugugguguuacgaccucuagccugagguugaccucggcuuuccuaaccuaucuagccgaacuccccuggaacggggggccauagagggugaaagccccguaggcuaaagauagguggaaaguggcuagagguagaguaccauccccugguuugggggugggaaguuaggggacacgugccucuaaggcuaaauaugucccgagaccgauagcaaacuaaguaccgugagggaaagcugaaaagaaccccggaagggggagugcaaagagccugaaaccgggugguuauacaggguguggcucgaaagaagugaacccuuccgaaggaaaggggcgcaagcccuuaguacgaggaagggcgaucggggucacgccuuucgucuugaaacacgggccggggaguucacaucaguggcgagcuuaaggagauuaucuccgaaggcauagggaaaccaagugcccgcagccuaguuucuaggcgaggggcagggucugucagggccugaagccacugaugugaggcuagaaaccgggcgaucuaguccggggcaggcugaaggugggggaaaccccacuggagggccgaauagggguucugacgugcaauucguucccuugaccucggacuaggggcaaaagaccaaucuagcccggugauagcuaguuccccccgaaaugcguccuagcgcagccucccuaaaggcagcucgcgggguagagugacagaucgggggcuccaggcgccuggggcuuccggucuaacuccgaacccacgagcgccgaagaaggggggagugggucacucggcguaagguuggguggcaaaaggggaacaacccagaccuggguuaaggccccaaagucccggcuaagugccaacgaaaaggcgucuccagccuuagacagcgggaaggugggcccagcagcagccauccucuaaggagugcguaacagcucacccgccgaggcuggaggcccuaaagauuggucggggcucaagccgggcgccgagacccaggagggggucucuacugagauccucugguaggggggcgcugugaugggguagaaggugggucgugagauccacuggacccgucacaggugcagaucccggcgguaguaacagcgaaggggggugagaaucccccucgccggaagggcaaggguuucccggcaacguucgucagccgggaguuagcguccuaagguagggccuaauagguaccuaccgaaagggaaagggguuaacauuccccugccucccggguaggugcgguaacgcaagccagacuccugacggauugggguagggagaguaggaccaccguccuacccaagcacucaagcccuuggagagccguaacggugagaagagggcgaaggugugaugggccuuccguuaggaggguucuccugaucccuaguccccaugaaaagggagucuggaacgaucccgggagaccguaccuagaaccgacacuggugcccgggugagaagcccaaggcgucugagggguaacccaggcuagggaacucggcaaauuagccccguaacuucgggagaaggggugccuaucgugguuuaacaaagccacgauaggucgcagugaccagagggaccugacuguuuaauaaaaacauagguccccgcuagcccgaaaggguguguacgggggcuaaauccuggccacuggugguugaaauccggguucaaccgggcgaagccccaccgaaggccggggguaacucugacccucuuaagguagccaaaugccuugccggguaaguuccggcgcgcaugaauggaucaacgcggucccuacugucccagccuggggccucgugaacgcccugagccggugcacaguccggcaucucccuacaccgagagaagaccccguggagcuucaccgcagccuggcguugucccucgggcguuuaugcguagaguaggugggaggggucgaaccuguccuuucgggggcaggggacccgaaagugaaacaccacccauggacgcucgagggacuaaccucucgaaagagaggaacaacgucaggugggcgguucggcuggggcggcacucccgcgaaaagauaacacgggagcccaaaggucggcucaggcgguacagaacgccgccguagagcgcaagggcaaaagccggccugacgugacccuuccaaguacggggucacgacgcgaaagcggggccuagcgaacgcucgugcccccacacgugggggccgggcaugacagaaaaguuaccccggggauaacagggucgucgcgggcgagagcucacaucgaccccgcgguuugcuacaucgaugucggcucuucccacccuggaggugcagcugccuccaaggguagggcugcccgcccguuaaaggggagcgugagcuggguuuagaccgucgcgagacaggucggacucuaaggguagggagugcggaccgcuugaggggaaggaaccccuaguacgagaggaacaggguuccggggccuccaguuuaccgguuguccgguagggcaaugccgggcagccgcgcccugagggguaaccgcugaaagcaucuaagcgggaaccccuccccuaaaagaggcggucaggcgccggggccuuccccuagaagaggggguugaugggguggggauguaagcuccaagguuguaagaccgaggaguuuaguccgccacucccaaucaggcuccccc <.<<<.<<<<<<....<<<..<<<<<<<<<<<<.....<<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>>...<<<....>>><<<<<<..>>>>>>.<<<<<<.....>>>>>>.>>...<<<<<<....<<......>>.....>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<....<<<...<<<<<<<<<.....>>>>>>>>>.....>>>......<<<<<<<<<<<<<<<<..>>>>>><<<<<<<..<<<<<<<<<<<<.....<<<<......>>>>.((......<<<.....))>>>...>>>>..>>>>>>>>>>>>>>>>>>>>>>>>>......<<<<<<<<......>>>>>>>>......<<<<<.((((((>>>>>...>>......>>.>>>>>>.>>................<<....>>....>>.........<<<<.....>>>>............>....>>>>>>.>>>>.....<<<<<<<<<<<....<<......<<<<<<<...<....<<<<<....>>>>>.....>..>>>>>>>...>>.>>>>>>>>>>>.<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>...<<<<<...<<<<.......>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>..<<<<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<<<....<<........>>..>>>>>...>>>>>>>>>...<<.......>>......>>>>>>......>>>>..<<<<<<....<<<<<....>>>>><<<<<<<<...<<<.<<<<<.<<<...<<<....<<<<<<<<<<<<<<<<<<>>>>>>>>>>>>>>>>>>..>>.>...>>>.>>>>>>>>......>>>>>>.>>..<<<<<<.<<<.....>>>.>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>.>...>>.........<<......>>...>>>>>...>>>>>>>>>>>>>...........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<<<<....>>>>>>>>>>....>>>>>><<<<<<<<<.<<<.....<<<<<<<<....>>>>>>>>...>>>>>>>>>>.>>.....>>>>>><......<<......<<<<<<.......>>>>>><<<<....<<<<<<<<...<<<<<<....<.....>..>>>>>>....<<{<<<...<<<<<<<<<.....>>>.>>>>>>....>>>..<<<<<........>>>>>>><<<<<<<<.....<<<....>>>...<<<<<<<<<<...<<<<<<<<<..<<<<<<<<<<<<<.[[[>>>>>>><<..<<<<.<..<<<<<<.....<<<<...>>>>.....>>>>>>...>>>>>...>><<<<<<<....>>>>>>>>>>>>>...>>>>>>>>>.........>>>>>>>>>>......>>>>>>>>.}....>>>....<<......>>>>>>><<<<.....>>>>..>>>>...<<<<.....<<<<<<<<.<<...............<<<<<....<<..>>.....>>>>><<<<<<<<<<<<<......>>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<....>>>>......>>>>>>>..<<<<.<<<..<<<<<<<......<<<<<......>>>>>.......>>>>>..>>>>>.<<<<<.......>>>>>.........<...........<<<<<<.....>>>>>>.....>....>>>>...>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<..<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<<<<<<<<<<<<.........<<<<<...<<........<<.<<<.....>>>>>.....>>.............>>>>>>>>>>>>>>>>>>>>>>>...<<<<<<....>>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<.............>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<..))))))>>>>>>>>>>..........>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>..<<<<.....>>>>......>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>...>>>>>>>>>>....<<<<<<<..<<<<<..<<<<<<<.................>>>>>>><<<<<...<.<<...<<<<<<<<<<]]].>>>>>..>>>>>...>>.>.>>>>>.<<<<<...<<<<<...........>>>>>...>>>>>>>>>>......>>>>>>>.<<..>><<<<<<<<<<<<.......>>>>>....<<<<<<<<<<<<....<<<<<..<<<<....>>>>..>>>>>...>>>>.>>>>>.>>>...>>>>>>>... ...((.(((((.....(((..(((((.((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...))).....((....)).(((((....))))).(((.((.....)).))).))...((((((....((...[..)).....))))).).........((....))...(((((.....((.]...))....)))))...((.(...(...((((.(((((.....))))).)))....).)....[..((((((((((.(((((..)))))..((((((..((((((((.(((...({((((......)))))[[......(((....}]])))...)))...)))))))))))))).)))))))))).)....((((((((......))))))))....]...(((.[[[[[[))).....))......)).)).))).))................((....))....))......(..((((.....))))...........)).....))))).))........(.((((((((....((......(((((.(...(....(((((....))))).....)..).)))))...)).)))))))).).[((((........))))((((((..(.(((((((((((((..((....((((.....))))....))...((....))...(((((...((((.......))))...)))))(((.((....)).)))...)))))))))))))..((((...((((((.....((((((((((.((((...(((((((....)))))))...)[))).....(((...(.((........)))..)))..).))))))))).(.((.......))...)..))))))......))))).((((((....(((((....)))))(((.((((...(((.(((((.(((...(((.....((((((..((((((((()))))))))..))))))...)).)...))).))))))))......)))).).))..(((((.((((.....)))).)))))....(((......)))...(((((((...((([[[...(.((((((.....((........(((.(.((((((((.......(((((..(([..((.........).)..))......(]..((......)).).)))))...)))))))).))))...........]]]))....))))))))))...)))))))((.(((..((....))..))).))....))))))(.(((((((.(((.....((((((((....))))))))...))))))))))..).....))))))(......((......((((((.......))))))((((....((((..((..(((((((....(.....)..))))))....(([.((...(((((((((.....))).))))))....))...(((.(........).)))))((((((((.....(((....)))...(((((((((....(((((((((..(((((((((((((.{.{)))))))((..((((.(..((((((.....(((.....))).....))))))...)))))...).)((((((....)))))).))))))...)))))))))(...).....)))))))))......)))))))).]...))).....((......)).))))(((.......)))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((((((......)))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}.(((.(((..(((((((..(....((((......)))).......))))))..)))))..(((.........)))..........((.(......).(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).)))))).....).{...(((((.....]}.)))))..((((((((.((..((......((((.((((((..(((((.(((((((((.((((((((.(((((.(.(.........(((((..(((.......(.(.((((...)))))..)...)))............)))))).).))))).))))))))...((((((....))))))....)))))))))..)))))..(((......[)).)(((((...........].)))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....((.((.(((((..]]]]]]))))))).))....).....))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..)))..((((.....))))......)))))..)...))).).....(((((((....))).))))....))...))))))))))....(((((((...((((..(((((((......(....).....)))))))(((((...(.((...((((((((((}.}.)))))..))))).[.)).).))))).(((((...((((.............))))...))))))))).......))))))).((())).((((((.((((.......)))).....(((.((((((((....(((((..(((......)))..)))))...))))]))))..)))...))))).)... Cryo-EM Structures and Translocation Mechanism of Crenarchaeota Ribosome; 23s rRNA (3000-MER) 8hl2 A16S 1492 4.1 RF01959,RF00177,RF01960,RF02542 URS00009F3A78_330779 37604686 0003735 0005840 330779 auuccgguugauccugccggacccgaccgcuaucgggguagggauaagccaugggagucuuacacucccggguaagggaguguggcggacggcugaguaacacguggcuaaccuacccucgggacggggauaaccccgggaaacuggggauaauccccgauagggaaggaguccuggaaugguuccuucccuaaagggcuauaggcuauuucccguuuguagccgcccgaggauggggcuacggcccaucaggcugucggugggguaaaggcccaccgaaccuauaacggguaggggccguggaagcgggagccuccaguugggcacugagacaagggcccaggcccuacggggcgcaccaggcgcgaaacguccccaaugcgcgaaagcgugagggcgcuaccccgagugccuccgcaggaggcuuuuccccgcucuaaaaaggcgggggaauaagcggggggcaagucuggugucagccgccgcgguaauaccagcuccgcgaguggucggggugauuacugggccuaaagcgccuguagccggcccaccaagucgccccuuaaaguccccggcucaaccggggaacugggggcgauacuggugggcuagggggcgggagaggcgggggguacucccggaguaggggcgaaauccuuagauaccgggaggaccaccaguggcggaagcgccccgcuagaacgcgcccgacggugagaggcgaaagccggggcagcaaacgggauuagauaccccgguagucccggcuguaaacgaugcgggcuaggugucgaguaggcuuagagccuacucggugccgcagggaagccguuaagcccgccgccuggggaguacggucgcaagacugaaacuuaaaggaauuggcgggggagcaccacaagggguggaaccugcggcucaauuggagucaacgccuggaaucuuaccgggggagaccgcaguaugacggccaggcuaacgaccuugccugacucgcggagaggaggugcauggccgucgccagcucguguugugaaauguccgguuaaguccggcaacgagcgagacccccaccccuaguugguauucuggacuccgguccagaaccacacuagggggacugccggcguaagccggaggaaggagggggccacggcaggucagcaugccccgaaacucccgggccgcacgcggguuacaauggcagggacaacgggaugcuaccucaaagggggagccaauccuuaaacccugccgcaguugggaucgagggcugaaacccgcccucgugaacgaggaaucccuaguaaccgcgggucaacaacccgcggugaauacgucccugcuccuugcacacaccgcccgucgcuccacccgagcgagaaaggggugaggucccuugcgauaagugggggaucgaacuccuuucccgcgaggggggagaagucguaacaagguagccguaggggaaccugcggcuggaucaccucau ...<<<<<.[.((((>>>>>.<<<<<<<<<.....<<<.<<......<<<.<<<..<<<..<<<<<<<<......>>>>>>>>>>>......<<........<<<<<<<..<<...<<<<<<<.<<<<<...<<<<<<......>>>>>.>...>>>>>..<<<<<<<<<<.<<......>>>>>>>>>>>>...<<.<<<<<<............>>>>>>>>.>>>>>>>..>>>>>>>>>.<<<....<<...<<<<<<<<.......>>>>>>>>.>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<............>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>..>>>....<<<<<<...>>>>>>...<<<<<<<.........>>>>>>>.....<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<......<<<<<<<.....>>>>>>>....>>>>>>>..>>>>>>>>>...<<<<<<.....<<<<<<<<<<.<<<<<<<.<..<<<......>>>.....>.>>>>>>>.>>>.......<<....>>.>>>>>>>....>>>.>>>...>>>...>>>>...<<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>>.........<<<<<<..<<<<<<<<<<<<<<.....>>>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<.<...<<<<<.......<<<.<<<.......>>>.>>>....>.>>>>...<<.<<<..<<<<<<<<.....<<<<<<.<<....>>...<<<<......>>>>..>>>>>>....<<<<<.<<<<<<<......<..<<<<<....>>>>>..>.....>>>>>>>.....<<<<<....>>>>>........>>>>>.....>>.>>>...>>>>>>>>.....>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<...<<..<<<.....>>>..>>....>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<.<<<<<<<<<..<<<<<<<<<<.....>>>>>>>>>>..>>>>>>>>>.>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ ...((((..[.[[[..)))).(((((((((.....(((.(((..[..(((.(((..(((..(.((((((......)))))).))))......(((.......(((.(((..((...(((((((.(((((....((((((....)))))).....)))))...((((((((..((......)).))))))))....(.((((.(..............).))))).)))))))..))))).))).(((.<..((...((((((((.......)))))))).))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).)...].(.(((...(((((....)))).))))).))..)))....((((((...))))))....((((((.........))))))......((((([[......((((.....((..]])).......)))).)))))..)))))))))..........((([[...(.((((...(((.(.(((((.(((((((((......(((((((.....)))))))....)))))))..))))))).)..(((((((.....((((((((((.(((((((....((........)).......))))))).))).......((....)).)))))))....))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((..((((((((((.....))))))))))..))...((..]])).....)))))))))).(((....>.((((....))))....)))...]]].]((.(...((((((..((.((((((..((((((((((......((........))..........(((((.(...((((.(......(((.(((.......))).)))...)..))))...((.(((...((((((((....((((((.((....))...((((......))))..))))))....(((((.(((((((.((......(((((....)))).)..)...))))))).).(..(((((....))))).....)..)))))....))).)))...)).)))))....).)))))...)).)))))))).(...(((((((.....(.(..((..((((...))))..))....)).....)))))))......(....(((((((........)))))))....)..)..))))))....((((((((.......))))))))......))...))))))..)..))..(.(..((.(.((((.(((..(((.(((((((((..((((((.(((.....))).))))))..))))))))).)))..))).))))..).))...)..)..(((((((((....)))))))))}........... Cryo-EM Structures and Translocation Mechanism of Crenarchaeota Ribosome; 16s rRNA (1493-MER) 8hl2 A5S 122 4.1 RF00001 URS000056704D_330779 37604686 0003735 0005840 330779 ugcccacccggucauagugagcggguaacacccggacucguuucgaacccggaaguuaagccgcucacgucagaggggccgugggauccgagagggcccgcagccucucugagcugggaugg ..<<..<<<<<<....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>>>.<<<<<<<<<<.<<<<<..<<....>>.>>>>>.>>>>>>>>>>>>>>>>..>> ..((..((((((....((((((((.....((((((.............))))..))....)))))))).((((((.((.(..(((..((....)).)))...))).))))))))))))..)) Cryo-EM Structures and Translocation Mechanism of Crenarchaeota Ribosome; 5s rRNA (122-MER) 8hl2 APTN 76 4.1 RF00005 URS00005AA258_330779 37604686 0030533 0006412 330779 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<...<<<<........>>>><<<<<<<.....>>>>>>.>...<<<<<.......>>>>>.>>>>>>.... ((((((...((((.....[..)))).(((((.......))))).....(((((..]....))))).)))))).... Cryo-EM Structures and Translocation Mechanism of Crenarchaeota Ribosome; tRNA (76-MER) 8hl2 AETN 76 4.1 RF00005 URS00005AA258_330779 37604686 0030533 0006412 330779 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>......<<<<.......>>>>.>>>>>>>.... (((((((..((((........)))).(((((.......))))).....((.((.......)).))))))))).... Cryo-EM Structures and Translocation Mechanism of Crenarchaeota Ribosome; tRNA (76-MER) 8hl2 AMRN 13 4.1 37604686 330779 uuuuuuuuuuuuu ............. ............. Cryo-EM Structures and Translocation Mechanism of Crenarchaeota Ribosome; mRNA (5'-R(P*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*U)-3') 8hl3 A23S 2996 4.8 RF02540,RF02541,RF02543,RF00002 URS0000759EE6_330779 37604686 0003735 0005840 330779 aagccucccgguggauggcucggcucgggcaccgaagaagggcgcggcaagcagcgaaaugcucgggugaggcgcaagcagccguugaccccgagguccccuaaugggauauccugccggguuuccggcucccgguuuauaacugggugggaaccccccgaacggaaacaucuuaguagggggaggaaaagaaaucaauugagauccccugaguaggggcgaccgaaagggggacagcccaaacuaaaccugccgaugauaagucgguggggaugugguguuacgaccucuagccugagguugaccucggcuuuccuaaccuaucuagccgaacuccccuggaacggggggccauagagggugaaagccccguaggcuaaagauagguggaaaguggcuagagguagaguaccauccccugguuugggggugggaaguuaggggacacgugccucuaaggcuaaauaugucccgagaccgauagcaaacuaaguaccgugagggaaagcugaaaagaaccccggaagggggagugcaaagagccugaaaccgggugguuauacaggguguggcucgaaagaagugaacccuuccgaaggaaaggggcgcaagcccuuaguacgaggaagggcgaucggggucacgccuuucgucuugaaacacgggccggggaguucacaucaguggcgagcuuaaggagauuaucuccgaaggcauagggaaaccaagugcccgcagccuaguuucuaggcgaggggcagggucugucagggccugaagccacugaugugaggcuagaaaccgggcgaucuaguccggggcaggcugaaggugggggaaaccccacuggagggccgaauagggguucugacgugcaauucguucccuugaccucggacuaggggcaaaagaccaaucuagcccggugauagcuaguuccccccgaaaugcguccuagcgcagccucccuaaaggcagcucgcgggguagagugacagaucgggggcuccaggcgccuggggcuuccggucuaacuccgaacccacgagcgccgaagaaggggggagugggucacucggcguaagguuggguggcaaaaggggaacaacccagaccuggguuaaggccccaaagucccggcuaagugccaacgaaaaggcgucuccagccuuagacagcgggaaggugggcccagcagcagccauccucuaaggagugcguaacagcucacccgccgaggcuggaggcccuaaagauuggucggggcucaagccgggcgccgagacccaggagggggucucuacugagauccucugguaggggggcgcugugaugggguagaaggugggucgugagauccacuggacccgucacaggugcagaucccggcgguaguaacagcgaaggggggugagaaucccccucgccggaagggcaaggguuucccggcaacguucgucagccgggaguuagcguccuaagguagggccuaauagguaccuaccgaaagggaaagggguuaacauuccccugccucccggguaggugcgguaacgcaagccagacuccugacggauugggguagggagaguaggaccaccguccuacccaagcacucaagcccuuggagagccguaacggugagaagagggcgaaggugugaugggccuuccguuaggaggguucuccugaucccuaguccccaugaaaagggagucuggaacgaucccgggagaccguaccuagaaccgacacuggugcccgggugagaagcccaaggcgucugagggguaacccaggcuagggaacucggcaaauuagccccguaacuucgggagaaggggugccuaucgugguuuaacaaagccacgauaggucgcagugaccagagggaccugacuguuuaauaaaaacauagguccccgcuagcccgaaaggguguguacgggggcuaaauccuggccacuggugguugaaauccggguucaaccgggcgaagccccaccgaaggccggggguaacucugacccucuuaagguagccaaaugccuugccggguaaguuccggcgcgcaugaauggaucaacgcggucccuacugucccagccuggggccucgugaacgcccugagccggugcacaguccggcaucucccuacaccgagagaagaccccguggagcuucaccgcagccuggcguugucccucgggcguuuaugcguagaguaggugggaggggucgaaccuguccuuucgggggcaggggacccgaaagugaaacaccacccauggacgcucgagggacuaaccucucgaaagagaggaacaacgucaggugggcgguucggcuggggcggcacucccgcgaaaagauaacacgggagcccaaaggucggcucaggcgguacagaacgccgccguagagcgcaagggcaaaagccggccugacgugacccuuccaaguacggggucacgacgcgaaagcggggccuagcgaacgcucgugcccccacacgugggggccgggcaugacagaaaaguuaccccggggauaacagggucgucgcgggcgagagcucacaucgaccccgcgguuugcuacaucgaugucggcucuucccacccuggaggugcagcugccuccaaggguagggcugcccgcccguuaaaggggagcgugagcuggguuuagaccgucgcgagacaggucggacucuaaggguagggagugcggaccgcuugaggggaaggaaccccuaguacgagaggaacaggguuccggggccuccaguuuaccgguuguccgguagggcaaugccgggcagccgcgcccugagggguaaccgcugaaagcaucuaagcgggaaccccuccccuaaaagaggcggucaggcgccggggccuuccccuagaagaggggguugaugggguggggauguaagcuccaagguuguaagaccgaggaguuuaguccgccacucccaaucaggcuccccc <.<<<.<<<<<<....<<<..<<<<<<<<<<<<.....<<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>>...<<<....>>><<<<<<..>>>>>>..<<<<<.....>>>>>..>>...<<<<<<....<<......>>.....>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<...<<<...<<<<<<<<<.....>>>>>>>>>.....>>>......<<<<<<<<<<<<<<<<..>>>>>><<<<<<<..<<<<<<<<.<<<.....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>>>>>>>>>>>>......<<<<<<<<......>>>>>>>>......<<<<<.((((((>>>>>..>>>......>>.>>>>>>.>>................<<....>>....>>.........<<<<.....>>>>............>....>>>>>>.>>>>......<<<<<<<<<<....<<......<<<<<<<...<....<<<<<....>>>>>.....>..>>>>>>>...>>.>>>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>...<<<<<...<<<<.......>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>..<<<<...<<<<<<.....<<<<<<<<<..<<<<...<<<<<<<....>>>>>>>...>.>>>....<<<<<....<<........>>..>>>>>...>>>>>>>>>...<<.......>>......>>>>>>......>>>>..<<<<<<....<<<<<....>>>>><<<<<<<<...<<<.<<<<<.<<<...<<<....<<<<<<<<<<<<<<<<<<>>>>>>>>>>>>>>>>>>..>>.>...>>>.>>>>>>>>......>>>>>>.>>..<<<<<<<<<<.....>>>>>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<........<<<.<<<<<<<<<<.......<<<<<..<....<<.........>.>...>..........<<......>>...>>>>>...>>>>>>>>>>>>>...........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<<<<....>>>>>>>>>>....>>>>>><<<<<<<<<.<<<.....<<<<<<<<....>>>>>>>>...>>>>>>>>>>.>>.....>>>>>><......<<......<<<<<<.......>>>>>><<<<....<<<<<<<<...<<<<<<....<.....>..>>>>>>......<<<<...<<<<<<<<<.....>>>.>>>>>>....>>>..<<<<<........>>>>>..<<<<<<<<.....<<<....>>>...<<<<<<<<<<...<<<<<<<<<..<<<<<<<<<<<<<.[[[>>>>>>><...<<<<<...<<<<<<.....<<<<...>>>>.....>>>>>>...>>>>>....><<<<<<<....>>>>>>>>>>>>>...>>>>>>>>>.........>>>>>>>>>>......>>>>>>>>.>....>>>....<<......>>>>>>><<<<.....>>>>..>>>>...<<<<.....<<<<<<<<.<<...............<<<<<....<....>.....>>>>><<<<<<<<<<<<<......>>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<....>>>>......>>>>>>>..<<<<.<<<..<<<<<<<......<<<<<......>>>>>.......>>>>>..>>>>>.<<<<<.......>>>>>.........<...........<<<<<<.....>>>>>>.....>....>>>>...>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<..<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<<<<<<<<<<<..........<<<<<...<<......<<<<.<<<.....>>>>>>>...>>.............>>>>>.>>>>>>>>>>>>>>>>>...<<<<<<....>>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<.............>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<..))))))>>>>>>>>>>..........>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>...>>>>>>>>>>....<<<<<<<..<<<<<..<<<<<<<.................>>>>>>><<<<<...<.<<...<<<<<<<<<<]]].>>>>>..>>>>>...>>.>.>>>>>.<<<<<...<<<<<...........>>>>>...>>>>>>>>>>......>>>>>>>.<<..>><<<<<<<<<<<<.......>>>>>....<<<<<<<<<<<<....<<<<<..<<<<....>>>>..>>>>>...>>>>.>>>>>.>>>...>>>>>>>... ...((.(((((.....(((..(((((.((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))(((((....))))).(((.((.....)).))).))...((((((....((...[..)).....))))).).........((....))...(((((.....((.]...))....)))))...((.(...(...((((((((((.....)))))))))....).)....[..((((((((((.(((((())))))..((((((..((((((((.(((...({((((......)))))[[......(((....}]])))...)))...)))))))))))))).)))))))))).)....((((((((......))))))))....]...(((.[[[[[[))).....))......)).)).))).))................((....))....))......(..((((.....))))...........)).....))))).)).........(((((((((....((......(((((.(...(....(((((....))))).....)..).)))))...)).)))))))).).[.(((........))).((((((....(((((((((((((..((....((((.....))))....))...((....))...(((((...((((.......))))...))))).((((......))))....)))))))))))))..((((...((((((.....((((((((((.((((....((((((....))))))....)[))).....(((...(.((........)))..)))..).))))))))).(.((.......))...)..))))))......))))..((((((....(((((....)))))(((((((....(((.(((((.(((...(((....(((((((.(((.(((((()))))).))).)))))))..)).)...))).)))))))).......))))).))..(((((.((.(.....).)).)))))....(((......)))...(((((((...((([[[...(.((((((.....((........(((.(.((((((((.......(((((..((...((.........).)..))......(...((......)).).)))))...)))))))).))))...........]]]))....))))))))))...)))))))((((((((((....))))))))))....))))))(.((((((..(((.....((((((((....))))))))...))).))))))..).....))))))(......((......((((((.......))))))((((....((((..((..(((((((....(.....)..))))))....(.[.((...(((((((((.....))).))))))....))...(((............))).)((((((((.....(((....)))...(((((((((....(((((((((...((((((((((((.{.{)))))))((..((((.(..((((((.....(((.....))).....))))))...)))))...).)((((((....)))))).)))))....)))))))))(...).....)))))))))......)))))))).]...))).....((......)).))))((((.....))))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((((((......)))))))))))))(...).......(((((((((.].((.........))...((.((((....((((....))))......)))).)).}.(((.(((..(((((((..(....((((......)))).......))))))..)))))..(((.........)))..........((.(......).(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).)))))).....).{...(((((.....]}.)))))..((((((((.((..((......((((.((((((..(((((.(((((((((.((((((((.((((..(.(.........(((((..(((......(..(.(((.....))))..)...)))............)))))).)..)))).))))))))...((((((....))))))....)))))))))..)))))..(((......[)).)(((((...........].)))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....((.((.(((((..]]]]]]))))))).))....).....))))..))))))......(((((...((((((...((.......))...))))))....))).).)......((((.((((((..(((((((((......))))))..)))..((((.....))))......)))))..)...))).).....(((((((....))).))))....))...))))))))))....(((((((...((((..(((((((......(....).....)))))))(((((...(.((...((((((((((}.}.)))))..))))).[.)).).))))).(((((...((((.............))))...))))))))).......))))))).((())).((((((.((((.......)))).....((((((((((((....(((((..(((......)))..)))))...))))]))))).)))...))))).)... Cryo-EM Structures and Translocation Mechanism of Crenarchaeota Ribosome; 23s rRNA (3000-MER) 8hl3 A16S 1492 4.8 RF01959,RF00177,RF01960,RF02542 URS00009F3A78_330779 37604686 0003735 0005840 330779 auuccgguugauccugccggacccgaccgcuaucgggguagggauaagccaugggagucuuacacucccggguaagggaguguggcggacggcugaguaacacguggcuaaccuacccucgggacggggauaaccccgggaaacuggggauaauccccgauagggaaggaguccuggaaugguuccuucccuaaagggcuauaggcuauuucccguuuguagccgcccgaggauggggcuacggcccaucaggcugucggugggguaaaggcccaccgaaccuauaacggguaggggccguggaagcgggagccuccaguugggcacugagacaagggcccaggcccuacggggcgcaccaggcgcgaaacguccccaaugcgcgaaagcgugagggcgcuaccccgagugccuccgcaggaggcuuuuccccgcucuaaaaaggcgggggaauaagcggggggcaagucuggugucagccgccgcgguaauaccagcuccgcgaguggucggggugauuacugggccuaaagcgccuguagccggcccaccaagucgccccuuaaaguccccggcucaaccggggaacugggggcgauacuggugggcuagggggcgggagaggcgggggguacucccggaguaggggcgaaauccuuagauaccgggaggaccaccaguggcggaagcgccccgcuagaacgcgcccgacggugagaggcgaaagccggggcagcaaacgggauuagauaccccgguagucccggcuguaaacgaugcgggcuaggugucgaguaggcuuagagccuacucggugccgcagggaagccguuaagcccgccgccuggggaguacggucgcaagacugaaacuuaaaggaauuggcgggggagcaccacaagggguggaaccugcggcucaauuggagucaacgccuggaaucuuaccgggggagaccgcaguaugacggccaggcuaacgaccuugccugacucgcggagaggaggugcauggccgucgccagcucguguugugaaauguccgguuaaguccggcaacgagcgagacccccaccccuaguugguauucuggacuccgguccagaaccacacuagggggacugccggcguaagccggaggaaggagggggccacggcaggucagcaugccccgaaacucccgggccgcacgcggguuacaauggcagggacaacgggaugcuaccucaaagggggagccaauccuuaaacccugccgcaguugggaucgagggcugaaacccgcccucgugaacgaggaaucccuaguaaccgcgggucaacaacccgcggugaauacgucccugcuccuugcacacaccgcccgucgcuccacccgagcgagaaaggggugaggucccuugcgauaagugggggaucgaacuccuuucccgcgaggggggagaagucguaacaagguagccguaggggaaccugcggcuggaucaccucau ...<<<<<.[.((((>>>>>.<<<<<<<<<<....<<<.<<......<<<.<<<..<<<..<<<<<<<<......>>>>>>>>>>>......<<........<<.<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<<<<<.<<......>>>>>>>>>>>....<.<<<<<<<............>>>>>>>>.>>>>>>>..>>>>>>.>>.<<<....<<...<<<<<<<<.......>>>>>>>>.>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<............>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>..>>>....<<<<<<...>>>>>>...<<<<<<<.........>>>>>>>.....<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>.>>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<......<<<<<<<.....>>>>>>>....>>>>>>>..>>>>>>>>>...<<<<<<.....<<<<<<<<<<.<<<<<<<....<<<......>>>.......>>>>>>>.>>>.......<<....>>.>>>>>>>....>>>.>>>...>>>...>>>>...<<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>>.........<<<<<<..<<<<<<<<<<<<<<.....>>>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]..<<<.<<<<<<<..<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<.<...<<<<<<......<<<.<<<.......>>>.>>>...>>.>>>>...<<.<<<..<<<<<<<<.....<<<<<<.<<....>>...<<<<......>>>>..>>>>>>....<<<<<.<<<<<<<..<<..<<.<<<<<....>>>>>.>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>>.....>>.>>>...>>>>>>>>.....>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<...<<<.<<<.....>>>.>>>....>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.......<..<<.<.<<<<.<<<..<<<.<<<<<<<<<..<<<<<<<<<<.....>>>>>>>>>>..>>>>>>>>>.>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ ...((((..[.[[[..)))).(((((((((.....(((.(((.....(((.(((..(((..((((((((......)))))))))))......(((.......(((.(((..((...(((((((.(((((....((((.(....).)))).....)))))...((((((((..((......)).))))))))....(.((((.(..............).))))).)))))))..))))).))).(((.[..((...((((((((.......)))))))).))......)))..(((((((......)))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).))..)))....((((((...))))))....((((((.........))))))......((((.[[......((((.....((..]])).......))))..))))..)))))))))..........((([[...(.((((...(((.(.(((((.(((((((((......(((((((.....)))))))....)))))))..))))))).)..(((((((.....((((((((((.(((((((....((........)).......))))))).))).......((....)).)))))))....))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((...(((((((((.....)))))))))...))...((..]])).....)))))))))).(((....]..(((....))).....)))...]]].]..(((.(((((((..((.((((((..((((((((((......((........))..........(((((.(...((((((......(((.(((.......))).)))...)).))))...((.(((...((((((((....((((((.((....))...((((......))))..))))))....(((((.(((((((.((......(((((....)))).)..)...))))))).).(..(((((....))))).....)..)))))....))).)))...)).)))))....).)))))...)).)))))))).(...(((((((.....(.(..((..((((...))))..))....)).....)))))))......(....(((((((........)))))))....)..)..))))))....((((((((.......))))))))......))...)))))))))).....(.(..((.(.((((.(((..(((.(((((((((..(.((((((((.....)))))))).)..))))))))).)))..))).))))..).))...)..)..(((((((((....)))))))))}........... Cryo-EM Structures and Translocation Mechanism of Crenarchaeota Ribosome; 16s rRNA (1493-MER) 8hl3 A5S 122 4.8 RF00001 URS000056704D_330779 37604686 0003735 0005840 330779 ugcccacccggucauagugagcggguaacacccggacucguuucgaacccggaaguuaagccgcucacgucagaggggccgugggauccgagagggcccgcagccucucugagcugggaugg ..<<..<<<<<.....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>>>.<<<<<<<<<<..<<<<..<<....>>.>>>>..>>>>>>>>>>.>>>>>..>> ..((..((((((....((((((((.....((.(((...(.....)...)))...))....)))))))).((((((((((.(((((..((....)).))))).))))))))))))))))..)) Cryo-EM Structures and Translocation Mechanism of Crenarchaeota Ribosome; 5s rRNA (122-MER) 8hl3 APTN 76 4.8 RF00005 URS00005AA258_330779 37604686 0030533 0006412 330779 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<...<<<<........>>>><<<<<<<.....>>>>>>.>...<<<<<.......>>>>>.>>>>>>.... ((((((...((((.....[..)))).(((((.......))))).....(((((..]....))))).)))))).... Cryo-EM Structures and Translocation Mechanism of Crenarchaeota Ribosome; tRNA (76-MER) 8hl3 AETN 76 4.8 RF00005 URS00005AA258_330779 37604686 0030533 0006412 330779 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<...<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>.>>>>>>.... ((((((...((((........)))).(((((.......))))).....((.((.......)).)).)))))).... Cryo-EM Structures and Translocation Mechanism of Crenarchaeota Ribosome; tRNA (76-MER) 8hl3 AMRN 13 4.8 37604686 330779 uuuuuuuuuuuuu ............. ............. Cryo-EM Structures and Translocation Mechanism of Crenarchaeota Ribosome; mRNA (5'-R(P*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*U)-3') 8hl4 A23S 2995 4.62 RF02540,RF02541,RF02543,RF00002 URS0000759EE6_330779 37604686 0003735 0005840 330779 aagccucccgguggauggcucggcucgggcaccgaagaagggcgcggcaagcagcgaaaugcucgggugaggcgcaagcagccguugaccccgagguccccuaaugggauauccugccggguuuccggcgcccgguuuauaacugggugggaaccccccgaacggaaacaucuuaguagggggaggaaaagaaaucaauugagauccccugaguaggggcgaccgaaagggggacagcccaaacuaaaccugccgaugauaagucgguggggaugugguguuacgaccucuagccugagguugaccucggcuuuccuaaccuaucuagccgaacuccccuggaacggggggccauagagggugaaagccccguaggcuaaagauagguggaaaguggcuagagguagaguaccauccccugguuugggggugggaaguuaggggacacgugccucuaaggcuaaauaugucccgagaccgauagcaaacuaaguaccgugagggaaagcugaaaagaaccccggaagggggagugcaaagagccugaaaccgggugguuauacaggguguggcucgaaagaagugaacccuuccgaaggaaaggggcgcaagcccuuaguacgaggaagggcgaucggggucacgccuuucgucuugaaacacgggccggggaguucacaucaguggcgagcuuaaggagauuaucuccgaaggcauagggaaaccaagugcccgcagccuaguuucuaggcgaggggcagggucugucagggccugaagccacugaugugaggcuagaaaccgggcgaucuaguccggggcaggcugaaggugggggaaaccccacuggagggccgaauagggguucugacgugcaauucguucccuugaccucggacuaggggcaaaagaccaaucuagcccggugauagcuaguuccccccgaaaugcguccuagcgcagccucccuaaaggcagcucgcgggguagagugacagaucgggggcuccaggcgccuggggcuuccggucuaacuccgaacccacgagcgccgaagaaggggggagugggucacucggcguaagguuggguggcaaaaggggaacaacccagaccuggguuaaggccccaaagucccggcuaagugccaacgaaaaggcgucuccagccuuagacagcgggaaggugggcccagcagcagccauccucuaaggagugcguaacagcucacccgccgaggcuggaggcccuaaagauuggucggggcucaagccgggcgccgagacccaggagggggucuacuagagauccucugguaggggggcgcugugaugggguagaaggugggucgugagauccacuggacccgucacaggugcagaucccggcgguaguaacagcgaaggggggugagaaucccccucgccggaagggcaaggguuucccggcaacguucgucagccgggaguuagccuccuaagguagggccuaauagguaccuaccgaaagggaaagggguuaacauuccccugccucccggguaggugcgguaacgcaagccagacuccugacggauugggguagggagaguaggaccaccguccuacccaagcacucaagcccuuggagagccguaacggugagaagagggcgaaggugugaugggccuuccguuaggaggguucuccugaucccuaguccccaugaaaagggagucuggaacgaucccgggagaccguaccuagaaccgacacuggugcccgggugagaagcccaaggcgucugagggguaacccaggcuagggaacucggcaaauuagccccguaacuucgggagaaggggugccuaucgugguuuaacaaagccacgauaggucgcagugaccagagggaccugacuguuuaauaaaaacauagguccccgcuagcccgaaaggguguguacgggggcuaaauccuggccacuggugguugaaauccggguucaaccgggcgaagccccaccgaaggccggggguaacucugacccucuuaagguagccaaaugccuugccggguaaguuccggcgcgcaugaauggaucaacgcggucccuacugucccagccuggggccucgugaacgcccugagccggugcacaguccggcaucucccuacaccgagagaagaccccguggagcuucaccgcagccuggcguugucccucgggcguuuaugcguagaguaggugggaggggucgaaccuguccuuucgggggcaggggacccgaaagugaaacaccacccauggacgcucgagggacuaaccucucgaaagagaggaacaacgucaggugggcgguucggcuggggcggcacucccgcgaaaagauaacacgggagcccaaaggucggcucaggcgguacagaacgccgccguagagcgcaagggcaaaagccggccugacgugacccuuccaaguacggggucacgacgcgaaagcggggccuagcgaacgcucgugcccccacacgugggggccgggcaugacagaaaaguuaccccggggauaacagggucgucgcgggcgagagcucacaucgaccccgcgguuugcuacaucgaugucggcucuucccacccuggaggugcagcugccuccaaggguagggcugcccgcccguuaaaggggagcgugagcuggguuuagaccgucgcgagacaggucggacucuaaggguagggagugcggaccgcuugaggggaaggaaccccuaguacgagaggaacaggguuccggggccuccaguuuaccgguuguccgguagggcaaugccgggcagccgcgcccugagggguaaccgcugaaagcaucuaagcgggaaccccuccccuaaaagaggcggucaggcgccggggccuuccccuagaagaggggguugaugggguggggauguaagcuccaagguuguaagaccgaggaguuuaguccgccacucccaaucaggcuccccc <.<<<.<<<<<<....<<<..<<<<<<<<<<<<.....<<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>>...<<<....>>><<<<<<..>>>>>><<<<<<<.....>>>>>>>>>...<<<<<<....<<<....>>>.....>>>>>.>.........<<<..>>>..<<<<<<.....<<.....>>....>>>>>>..<<<...<<<...<<<<<<<<<.....>>>>>>>>>.....>>>......<<<<<<<<<<<<<<<<..>>>>>><<<<<<<..<<<<<<<<.<<<.....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>>>>>>>>>>>>......<<<<<<<<......>>>>>>>>.......<<<<.((((((>>>>...>>>......>>.>>>>>>.>>................<<....>>....>>.........<<<<.....>>>>............>....>>>>>>.>>>>.....<<<<<<<<<<<....<<......<<<<<<<...<....<<<<<....>>>>>.....>..>>>>>>>...>>.>>>>>>>>>>>.<<<<........>>>><<<<<<...<<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>...<<<<<...<<<<.......>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>>.<<<<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<<<....<<........>>..>>>>>...>>>>>>>>>...<<.......>>......>>>>>>......>>>>..<<<<<<....<<<<<....>>>>><<<<<<<<...<<<.<<<<<.<<<...<<<....<<<<<<<<<<<<<<<<<<>>>>>>>>>>>>>>>>>>..>>.>...>>>.>>>>>>>>......>>>>>>.>>..<<<<<<.<<<.....>>>.>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>.>...>>.........<<......>>...>>>>>...>>>>>>>>>>>>>...........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<.<....>.>.>>>>>>....>>>>>><<<<<<<<<.<<<.....<<<<<<<<....>>>>>>>>...>>>>>>>>>>.>>.....>>>>>><......<<......<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<....<.....>..>>>>>>....<<.<<<...<<<<<<<<<.....>>>.>>>>>>....>>>..<<<<<........>>>>>>><<<<<<<<.....<<<....>>>...<<<<<<<<<<...<<<<<<<<<..<<<<<<<<<<<<<.[[[>>>>>>><<..<<<<.<..<<<<<<.....<<<<...>>>>.....>>>>>>...>>>>>...>><<<<<<<....>>>>>>>>>>>>>...>>>>>>>>>.........>>>>>>>>>>......>>>>>>>>......>>.....<<......>>>>>>><<<<.....>>>>..>>>>...<<<<.....<<<<<<<<.<<...............<<<<<....<....>.....>>>>><<<<<<<<<<<<<......>>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<....>>>>......>>>>>>>..<<<<.<<<..<<<<<<<......<<<<<......>>>>>.......>>>>>..>>>>>.<<<<<.......>>>>>.........<...........<<<<<<.....>>>>>>.....>....>>>>...>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<..<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<<<<<<<<<<<<.........<<<<<..<<<........<<.<<<.....>>>>>.....>>>............>>>>>>>>>>>>>>>>>>>>>>>...<<<<<<....>>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<.............>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<..))))))>>>>>>>>>>..........>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>..<<<<.....>>>>......>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>...>>>>>>>>>>....<<<<<<<..<<<<<..<<<<<<<.................>>>>>>><<<<<...<.<<...<<<<<<<<<<]]].>>>>>..>>>>>...>>.>.>>>>>.<<<<<...<<<<<...........>>>>>...>>>>>>>>>>......>>>>>>>.<<..>><<<<<<<<<<<<.......>>>>>....<<<<<<<<<<<<....<<<<<..<<<<....>>>>..>>>>>...>>>>.>>>>>.>>>...>>>>>>>... ...((.(((((.....(((..(((((.((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...))).....((....)).(((((....))))).(((.((.....)).))).))...((((((....((...[..)).....))))).).........((....))...(((((.....((.]...))....)))))...((.(...(...((((.(((((.....))))).)))....).)....[..((((((((((.(((((..)))))..((((((..((((((((.(((...({((((......)))))[[......(((....}]])))...)))...)))))))))))))).)))))))))).)....((((((((......))))))))....]....((.[[[[[[))......))......)).)).))).))................((....))....))......(..((((.....))))...........)).....))))).))........(.((((.(((....((......(((((.(...(....(((((....))))).....)..).)))))...)).))).)))).).[((((........))))((((((....(((((((((((((..(((...((((.....))))...)))...((....))...(((((...((((.......))))...)))))((((((....))))))...)))))))))))))..((((...((((((.....((((((((((.((((....((((((....))))))....)[))).....(((...(.((........)))..)))..).))))))))).(.((.......))...)..))))))......))))..((((((....(((((....)))))(((.((((...(((.(((((.(((...(((....((((((((.((((((((())))))))).))))))))..)).)...))).))))))))......)))).).))..(((((.((.(.....).)).)))))....(((......)))...(((((((...((([[[...(.((((((.....((........(((.((((((((((.......(((((.((([..((.........).)..))).....(]..((......)).).)))))...)))))))))))))...........]]]))....))))))))))...)))))))(((((((.........)))))))....))))))(.((((((..(((......(((((((....)))))))....))).))))))..).....))))))(......((......((((((.......))))))((((....((((..((..(((((((....(.....)..))))))....(([.((...(((((((((.....))).))))))....))...(((............)))))((((((((.....(((....)))...(((((((((....(((((((((...((((((((((((.{.{)))))))((..((((.(..((((((.....(((.....))).....))))))...)))))...)).((((((....)))))).)))))....)))))))))(...).....)))))))))......))))))))...].))).....((......)).))))((((.....))))..))))...((((.....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((((.(......).)))))))))))(...).......(((((((((.].((.........))...(((((((....((((....))))......))))))).}.(((.(((..(((((((..(....((((......)))).......))))))..)))))(.(((.........))).)........((.(......).(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).)))))).....).{...(((((.....]}.)))))..((((((((.((..((......((((.((((((..(((((.(((((.(((.((((((((.(((((.(.(.........(((((..(((......(..(.(((.....))))..)...)))............)))))).).))))).))))))))...((((((....))))))....))).)))))..)))))..(((......[)).)(((((...........].)))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(((((..]]]]]]))))))))))....).....))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......((((.((((((..(((((((((......))))))..)))..((((.....))))......)))))..)...))).).....(((((((....))).))))....))...))))))))))....(((((((...((((..(((((((......(....).....)))))))(((((...(.((...((((((((((}.}.)))))..))))).[.)).).))))).(((((...((((.............))))...))))))))).......))))))).((())).((((((.((((.......)))).....(((.(((((((.....(((((..(((......)))..)))))....)))]))))..)))...))))).)... Cryo-EM Structures and Translocation Mechanism of Crenarchaeota Ribosome; 23s rRNA (3000-MER) 8hl4 A16S 1492 4.62 RF01959,RF00177,RF01960,RF02542 URS00009F3A78_330779 37604686 0003735 0005840 330779 auuccgguugauccugccggacccgaccgcuaucgggguagggauaagccaugggagucuuacacucccggguaagggaguguggcggacggcugaguaacacguggcuaaccuacccucgggacggggauaaccccgggaaacuggggauaauccccgauagggaaggaguccuggaaugguuccuucccuaaagggcuauaggcuauuucccguuuguagccgcccgaggauggggcuacggcccaucaggcugucggugggguaaaggcccaccgaaccuauaacggguaggggccguggaagcgggagccuccaguugggcacugagacaagggcccaggcccuacggggcgcaccaggcgcgaaacguccccaaugcgcgaaagcgugagggcgcuaccccgagugccuccgcaggaggcuuuuccccgcucuaaaaaggcgggggaauaagcggggggcaagucuggugucagccgccgcgguaauaccagcuccgcgaguggucggggugauuacugggccuaaagcgccuguagccggcccaccaagucgccccuuaaaguccccggcucaaccggggaacugggggcgauacuggugggcuagggggcgggagaggcgggggguacucccggaguaggggcgaaauccuuagauaccgggaggaccaccaguggcggaagcgccccgcuagaacgcgcccgacggugagaggcgaaagccggggcagcaaacgggauuagauaccccgguagucccggcuguaaacgaugcgggcuaggugucgaguaggcuuagagccuacucggugccgcagggaagccguuaagcccgccgccuggggaguacggucgcaagacugaaacuuaaaggaauuggcgggggagcaccacaagggguggaaccugcggcucaauuggagucaacgccuggaaucuuaccgggggagaccgcaguaugacggccaggcuaacgaccuugccugacucgcggagaggaggugcauggccgucgccagcucguguugugaaauguccgguuaaguccggcaacgagcgagacccccaccccuaguugguauucuggacuccgguccagaaccacacuagggggacugccggcguaagccggaggaaggagggggccacggcaggucagcaugccccgaaacucccgggccgcacgcggguuacaauggcagggacaacgggaugcuaccucaaagggggagccaauccuuaaacccugccgcaguugggaucgagggcugaaacccgcccucgugaacgaggaaucccuaguaaccgcgggucaacaacccgcggugaauacgucccugcuccuugcacacaccgcccgucgcuccacccgagcgagaaaggggugaggucccuugcgauaagugggggaucgaacuccuuucccgcgaggggggagaagucguaacaagguagccguaggggaaccugcggcuggaucaccucau ...<<<<<.[.((((>>>>>.<<<<<<<<<.....<<<.<<......<<<.<<<..<<<..<<<<<<<<......>>>>>>>>>>>......<<........<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>..<<<<<<<<<<.<<......>>>>>>>>>>>>...<.<<<<<<..............>>>>>>>.>>>>>>>..>>>>>>>>>.<<<....<<...<<<<<<<<.......>>>>>>>>.>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<............>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>..>>>....<<<<<<...>>>>>>...<<<<<<<.........>>>>>>>.....<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<......<<<<<<<.....>>>>>>>....>>>>>>>..>>>>>>>>>...<<<<<<.....<<<<<<<<<<.<<<<<<<....<<<......>>>.......>>>>>>>.>>>.......<<....>>.>>>>>>>....>>>.>>>...>>>...>>>>...<<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>>.........<<<<<<..<<<<<<<<<<<<<<.....>>>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<.<...<<<<........<<<.<<<.......>>>.>>>......>>>>...<<.<<<..<<<<<<<<.....<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>....<<<<<.<<<<<<<.<<<..<<<<<<<<....>>>>>>>>>>..>>>>>>>>.....<<<<<....>>>>>........>>>>>.....>>.>>>...>>>>>>>>.....>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<...<<..<<<.....>>>..>>....>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<.<<<<<<<<<..<<<<<<<<<<.....>>>>>>>>>>..>>>>>>>>>.>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ ...((((..[.[[[..)))).(((((((((.....(((.(((.....(((.(((..(((..((((((((......)))))))))))......(((.......(((.(((..((...(((((((.(((((....((((.(....).)))).....)))))...((((((((..((......)).))))))))....(.((((((..............))))))).)))))))..))))).))).(((....((...((((((((.......)))))))).))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).))..)))....((((((...))))))....((((((.........))))))......((((([[......((((.....((..]])).......)))).)))))..)))))))))..........((([[...(.((((...(((.(.(((((.(((((((((......(((((((.....)))))))....)))))))..))))))).)..(((((((.....((((((((((.(((((((....((........)).......))))))).))).......((....)).)))))))....))).)))..))))...))))....((((((....(...((((.........))))...).))))))......{...((((((..(((..(((((((((.....)))))))))..)))...((..]])).....)))))))))).(((......((((....))))....)))...]]].]((((..(((((((..((.((((((..((((((((((......((........))..........(((((.(...((((.(......(((.(((.......))).)))...)..))))...((.(((...((((((((....((((((.((....))...((((......))))..))))))....(((((.(((((((.((......(((((....)))).)...)..))))))).).(..(((((....))))).....)..)))))....))).)))...)).)))))....).)))))...)).)))))))).(...(((((((.....(.(..((..((((...))))..))....)).....)))))))......(....(((((((........)))))))....)..)..))))))....((((((((.......))))))))......))...))))))).)).))..(.(..((.(.((((.(((..(((.(((((((((..(.((((..((.....))..)))).)..))))))))).)))..))).))))..).))...)..)..(((((((((....)))))))))}........... Cryo-EM Structures and Translocation Mechanism of Crenarchaeota Ribosome; 16s rRNA (1493-MER) 8hl4 A5S 122 4.62 RF00001 URS000056704D_330779 37604686 0003735 0005840 330779 ugcccacccggucauagugagcggguaacacccggacucguuucgaacccggaaguuaagccgcucacgucagaggggccgugggauccgagagggcccgcagccucucugagcugggaugg ..<<..<<<<<.....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>>>.<<<<<<<<<<..<<<<..<<....>>.>>>>..>>>>>>>>>>.>>>>>..>> ..((..((((((....((((((((.....((.(((...(.....)...)))...))....)))))))).((((((((((.(((((..((....)).))))).))))))))))))))))..)) Cryo-EM Structures and Translocation Mechanism of Crenarchaeota Ribosome; 5s rRNA (122-MER) 8hl4 APTN 76 4.62 RF00005 URS00005AA258_330779 37604686 0030533 0006412 330779 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<...<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>.>>>>>>.... ((((((...((((.....[..)))).(((((.......))))).....((.((..]....)).)).)))))).... Cryo-EM Structures and Translocation Mechanism of Crenarchaeota Ribosome; tRNA (76-MER) 8hl5 A23S 2991 5.72 RF02540,RF02541,RF02543,RF00002 URS0000759EE6_330779 37604686 0003735 0005840 330779 aagccucccgguggauggcucggcucgggcaccgaagaagggcgcggcaagcagcgaaaugcucgggugaggcgcaagcagccguugaccccgagguccccuaaugggauauccugccggguuccggcgcccgguuuauaacugggugggaaccccccgaacggaaacaucuuaguagggggaggaaaagaaaucaauugagauccccugaguaggggcgaccgaaagggggacagcccaaacuaaaccugccgaugauaagucgguggggaugugguguuacgaccucuagccugagguugaccucggcuuuccuaaccuaucuagccgaacuccccuggaacggggggccauagagggugaaagccccguaggcuaaagauagguggaaaguggcuagagguagaguaccauccccugguuugggggugggaaguuaggggacacgugccucuaaggcuaaauaugucccgagaccgauagcaaacuaaguaccgugagggaaagcugaaaagaaccccggaagggggagugcaaagagccugaaaccgggugguuauacaggguguggcucgaaagaagugaacccuuccgaaggaaaggggcgcaagcccuuaguacgaggaagggcgaucggggucacgccuuucgucuugaaacacgggccggggaguucacaucaguggcgagcuuaaggagauuaucuccgaaggcauagggaaaccaagugcccgcagccuaguuucuaggcgaggggcagggucugucagggccugaagccacugaugugaggcuagaaaccgggcgaucuaguccggggcaggcugaaggugggggaaaccccacuggagggccgaauagggguucugacgugcaauucguucccuugaccucggacuaggggcaaaagaccaaucuagcccggugauagcuaguuccccccgaaaugcguccuagcgcagccucccuaaaggcagcucgcgggguagagugacagaucgggggcuccaggcgccuggggcuuccggucuaacuccgaacccacgagcgccgaagaaggggggagugggucacucggcguaagguuggguggcaaaaggggaacaacccagaccuggguuaaggccccaaagucccggcuaagugccaacgaaaaggcgucuccagccuuagacagcgggaaggugggcccagcagcagccauccucuaaggagugcguaacagcucacccgccgaggcuggaggcccuaaagauuggucggggcucaagccgggcgccgagacccaggagggggucucuacugagauccucugguaggggggcgcugugaugggguagaaggugggucgugagauccacuggacccgucacaggugcagaucccggcgguaguaacagcgaaggggggugagaaucccccucgccggaagggcaaggguuucccggcaacguucgucagccgggaguuagcguccuaagguagggccuaauagguaccuaccgaaagggaaagggguuaacauuccccugccucccggguaggugcgguaacgcaagccagacuccugacggauugggguagggagaguaggaccaccguccuacccaagcacucaagcccuuggagagccguaacggugagaagagggcgaaggugugaugggccuuccguuaggaggguucuccugaucccuaguccccaugaaaagggagucuggaacgaucccgggagaccguaccuagaaccgacacuggugcccgggugagaagcccaaggcgucugagggguaacccaggcuagggaacucggcaaauuagccccguaacuucgggagaaggggugccuaucgugguuuaacaaagccacgauaggucgcagugaccagagggaccugacuguuuaauaaaaacauagguccccgcuagcccgaaaggguguguacgggggcuaaauccuggccacuggugguugguuaaauccggguucaaccgggcgaagccccaccgaaggccggggguacccucuuaagguagccaaaugccuugccggguaaguuccggcgcgcaugaauggaucaacgcggucccuacugucccagccuggggccucgugaacgcccugagccggugcacaguccggcaucucccuacaccgagagaagaccccguggagcuucaccgcagccuggcguugucccucgggcguuuaugcguagaguaggugggaggggucgaaccuguccuuucgggggcaggggacccgaaagugaaacaccacccauggacgcucgagggacuaaccucucgaaagagaggaacaacgucaggugggcgguucggcuggggcggcacucccgcgaaaagauaacacgggagcccaaaggucggcucaggcgguacagaacgccgccguagagcgcaagggcaaaagccggccugacgugacccuuccaaguacggggucacgacgcgaaagcggggccuagcgaacgcucgugcccccacacgugggggccgggcaugacagaaaaguuaccccggggauaacagggucgucgcgggcgagagcucacaucgaccccgcgguuugcuacaucgaugucggcucuucccacccuggaggugcagcugccuccaaggguagggcugcccgcccguuaaaggggagcgugagcuggguuuagaccgucgcgagacaggucggacucuaaggguagggagugcggaccgcuugaggggaaggaaccccuaguacgagaggaacaggguuccggggccuccaguuuaccgguuguccgguagggcaaugccgggcagccgcgcccugagggguaaccgcugaaagcaucuaagcgggaaccccuccccuaaaagaggcggucaggcgccggggccuuccccuagaagaggggguugaugggguggggauguaagcuccaagguuguaagaccgaggaguuuaguccgccacucccaaucaggcuccccc <.<<<.<<<<<<.....<<..<<<<<<<<<<<<.....<<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>>...<<<....>>><<<<<<.>>>>>><<<<<<<<...>>>>>>>>>>...<<<<<<....<<<....>>>.....>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<...<<<...<<<<<<<<<.....>>>>>>>>>.....>>>......<<<<<<<<<<<<<<<<..>>>>>><<<<<<<...<<<<<<<.<<<.....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>.>>>>>>>>>>>>>>>>>......<<<<<<<<......>>>>>>>>.......<<<<.((((((>>>>...>>>......>>.>>>>>>.>>................<<....>>....>>.........<<<<.....>>>>.................>>>>>>.>>>>......<<<<<<<<<<....<<......<<<<<<<...<....<<<<<....>>>>>.....>..>>>>>>>...>>.>>>>>>>>>>..<<<<........>>>><<<<<<...<<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>...<<<<<...<<<<.......>>>>...>>>>><<<<<<....>>>>>>...>>>>>>>>>>>>>>.<<<<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<<<<....<<........>>..>>>>>...>>>>>>>>>...<<.......>>......>>>>>>...>..>>>>..<<<<<<....<<<<<....>>>>><<<<<<<<...<<<.<<<<<.<<<...<<<....<<<<<<<<<<<<<<<<<<>>>>>>>>>>>>>>>>>>..>>.>...>>>.>>>>>>>>......>>>>>>.>>..<<<<<<.<<<.....>>>.>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<........<<<.<<<<<<<<<<.......<<<<..<<....<<.........>>....>>.........<<......>>....>>>>...>>>>>>>>>>>>>...........)))>>....>>>>>>.>>>...>>>>>>><<<<<<<<<<....>>>>>>>>>>....>>>>>><<<<<<<<<.<<<.....<<<<<<<<....>>>>>>>>...>>>>>>>>>>.>>.....>>>>>><......<<......<<<<<<.......>>>>>><<<<....<<<<..<<...<<<<<<....<.....>..>>>>>>....<.{<<<...<<<<<<.<<.....>>..>>>>>>....>>>..<<<<<........>>>>>.><<<<<<<<.....<<<....>>>...<<<<<<<<<<...<<<<<<<<<..<<<<<<<<<<<<<.[[[>>>>>>>....<<<<.<..<<<<<<.....<<<<...>>>>.....>>>>>>...>>>>>.....<<<<<<<....>>>>>>>>>>>>>...>>>>>>>>>.........>>>>>>>>>>......>>>>>>>>.}....>>.....<<......>>.>>>><<<<.....>>>>..>>>>...<<<<.....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<<<<<<<<......>>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<....>>>>......>>>>>>>..<<<<.<<<..<<<<<<<..<<<<...<<<<<......>>>>>...>>>>>>>>>..>>>>><<<<<..>>>>>....................<<<<<<.....>>>>>>..........>>>>...>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<..<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<<<<<<<<.<<<.........<<<<<..<<<...........<.<.....>.>.......>>>............>>>>>>>>.>>>>>>>>>>>>>>...<<<<<<....>>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<.............>>>>>.(<<...<<<<<<<...<<<<<<.......>>>>>>.....<<)..(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<..))))))>>>>>>>>>>..........>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.........<<<.<.<<<<..<<<<<<<<<......>>>>>>>..>>..<<<<.....>>>>......>>>>...>...>>>.......<<<<<<<....>>>.>>>>....>>...>>>>>>>>>>....<<<<<<<..<<<<<..<<<<<<<.................>>>>>>><<<<<.....<<...<<<<<<<<<<]]].>>>>>..>>>>>...>>...>>>>>.<<<<<...<<<<<...........>>>>>...>>>>>>>>>>......>>>>>>>.<<..>><<<<<<<<<<<<.......>>>>>....<<<<<<<<<<<<....<<<<<..<<<<....>>>>..>>>>>...>>>>.>>>>>.>>>...>>>>>>>... ..(((.(((((.....(((..(((((.((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...))).....((....)).(((((...))))).(((.((.....)).))).))...((((((.....(...[..)......))))).).........((....))...((((......((.]...)).....))))...((.(...(...(((..((((.......))))..))....).)....[..((((((((((.(((((..))))).(((((((...(((((((.(((...({((((......)))))[[......(((....}]])))...)))...))))))).))))))))))))))))).)....(((.((((......)))).)))....]...(((.[[[[[[))).....))......)).)).))).))................((....))....))......(..((((.....))))...........)).....))))).)).).......(.(((((((....((......(((((.(...(.....((((....))))......)..).)))))...)).)))))))..).[.(((........))).((((((....(((((((((((((..((....((((.....))))....))...((....))...(((((...((((.......))))...)))))(((.(......).)))...)))))))))))))..((((...((((((.....((((((.(((.(((.....((((((....)))))).....[))).....(((...(.((........)))..)))..).)).)))))).(.((.......))...)..))))))......))))..((((((....(((((....))))).((.(((....(((.(((((.(((...(((....(((((((.(((((((((()))))))))).)))))))..)).)...))).)))))))).......))).).)...(.(((.(.((.....)).).))).)....(((......)))...(((((((...((([[[...(.((((((.....((........(((.((((((((((.......(((((.(((...((.........).)..))).....(...((......)).).)))))...)))))))))))))...........]]]))....))))))))))...)))))))(((((((.((....)).)))))))....))))))(.(((((((.(((......((((.((....)).))))....))))))))))..).....))))))(......((.......(((((.......))))).((((....((((..((..(((((((....(.....)..))))))....(([.((...((((((.((.....))..))))))....))...(((............)))))((((((((.....(((....)))...(((((((((....(((.(.(((..(((((((((((((.{.{)))))))((...(((.(..((((((......((.....))......))))))...))))....).)((((((....)))))).))))))...))).).)))(...).....)))))))))......)))))))).]...))).....((......)).))))(((.......)))..))))...((((.....((((((((.((..(....(........((((....(.{..).....))))..((((((((((.(......).)))))))))).(...).......(((((((.(.].((.........))...((.((((....((((....))))......)))).)).}.(((.(((..(((((((..((......((((......))))......)))))))..)))))(((((()))))).........(.(......).(((((.......)))))..).......)))....)..))))))).)..))).)))))))).)))))).....).{...(((((.....]}.)))))..((((((((.((..((......((((.((((((..(((((.(((((.(((.((((((((((((..((((.........(((((..(((.......(.(.(((.....))))..)...)))............)))))))))..))))))))))))...((((((....))))))....))).)))))..)))))..(((......[)).)(((((...........].)))))([((...((.((((.(.((((((.......))))))...).((][.[[[))....)))).))...((((((((...........)))))))).(((....))).))]]].].....((.((.(((((..]]]]]]))))))).))....).....))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......((((.((.(((..((.(((((........)))))...))..((((.....))))......))).)..)...))).).....(((((((....))).))))....))...))))))))))....((((((....((((..(((((((......(....).....))))))).((((...(.(....((((.(((((}.}.)))))...)))).[..).).))))..(((((...((((.............))))...)))))))))........)))))).((())).(.((((.((((.......)))).....(((((((((((......((((..(((......)))..)))).....)))]))))).)))...))))..)... Cryo-EM Structures and Translocation Mechanism of Crenarchaeota Ribosome; 23S rRNA (2991-MER) 8hl5 A16S 1492 5.72 RF01959,RF00177,RF01960,RF02542 URS00009F3A78_330779 37604686 0003735 0005840 330779 auuccgguugauccugccggacccgaccgcuaucgggguagggauaagccaugggagucuuacacucccggguaagggaguguggcggacggcugaguaacacguggcuaaccuacccucgggacggggauaaccccgggaaacuggggauaauccccgauagggaaggaguccuggaaugguuccuucccuaaagggcuauaggcuauuucccguuuguagccgcccgaggauggggcuacggcccaucaggcugucggugggguaaaggcccaccgaaccuauaacggguaggggccguggaagcgggagccuccaguugggcacugagacaagggcccaggcccuacggggcgcaccaggcgcgaaacguccccaaugcgcgaaagcgugagggcgcuaccccgagugccuccgcaggaggcuuuuccccgcucuaaaaaggcgggggaauaagcggggggcaagucuggugucagccgccgcgguaauaccagcuccgcgaguggucggggugauuacugggccuaaagcgccuguagccggcccaccaagucgccccuuaaaguccccggcucaaccggggaacugggggcgauacuggugggcuagggggcgggagaggcgggggguacucccggaguaggggcgaaauccuuagauaccgggaggaccaccaguggcggaagcgccccgcuagaacgcgcccgacggugagaggcgaaagccggggcagcaaacgggauuagauaccccgguagucccggcuguaaacgaugcgggcuaggugucgaguaggcuuagagccuacucggugccgcagggaagccguuaagcccgccgccuggggaguacggucgcaagacugaaacuuaaaggaauuggcgggggagcaccacaagggguggaaccugcggcucaauuggagucaacgccuggaaucuuaccgggggagaccgcaguaugacggccaggcuaacgaccuugccugacucgcggagaggaggugcauggccgucgccagcucguguugugaaauguccgguuaaguccggcaacgagcgagacccccaccccuaguugguauucuggacuccgguccagaaccacacuagggggacugccggcguaagccggaggaaggagggggccacggcaggucagcaugccccgaaacucccgggccgcacgcggguuacaauggcagggacaacgggaugcuaccucaaagggggagccaauccuuaaacccugccgcaguugggaucgagggcugaaacccgcccucgugaacgaggaaucccuaguaaccgcgggucaacaacccgcggugaauacgucccugcuccuugcacacaccgcccgucgcuccacccgagcgagaaaggggugaggucccuugcgauaagugggggaucgaacuccuuucccgcgaggggggagaagucguaacaagguagccguaggggaaccugcggcuggaucaccucau ...<<<<....((((.>>>>.<<<<<<<<......<<<.<<......<<<.<<<..<<<...<<<<<<<......>>>>>>>.>>>......<<........<<<<<<...<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<<<<<.<<......>>>>>>>>>>>....<.<<<<<<<<..........>>>>>>>>>.>>>>>>>..>>.>>>>>>.<<<....<<....<<<<<<<.......>>>>>>>..>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<............>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>..>>>....<<<<<<...>>>>>>...<<<<<<<.........>>>>>>>.....<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>...>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<......<<<<<<<.....>>>>>>>....>>>>>>>..>>>>>>>>>...<<<<<<.....<<<<<<<<<..<<<<<<<....<<<......>>>.......>>>>>>>..>>.......<<....>>.>>>>>>>....>>>.>>>...>>>...>>>>...<<<<<<<...<<...<<<<.........>>>>...>>>>>>>>>.........<<<<<<..<<<<<<<<<<<<<<.....>>>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..))))..<<<<<.<<<<<<<..<<.<<<<<..<<<<<<<<<........<<........>>..........<<<<<.<...<<<<<.......<<<.<<<.......>>>.>>>....>.>>>>...<<.<<<..<<<<<<<<.....<<<<<<.<<....>>...<<<<......>>>>..>>>>>>....<<<<<.<<<<<<<...<..<<.<<<<<....>>>>>.>>>....>>>>>>>.....<<<<<....>>>>>........>>>>>.....>>.>>>...>>>>>>>>.....>>>>>>......>>>>>>>>.>...<<<<<<<.....<<...<<..<<<.....>>>..>>....>>.....>>>>>>>...........<<<<<<<........>>>>>>>...........>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<.<<<<<<<<<..<<<<<<<<<<.....>>>>>>>>>>..>>>>>>>>>.>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ ...((((....[[[..)))).(((((((.(.....(((.(((.....(((.(((..(((..((((((((......)))))))))))......(((.......(((.(((..((...(((((((.(((((....((((.(....).)))).....)))))...((((((....((......))...))))))....(.((((.(..............).))))).)))))))..))))).))).(((.[..((...((((((((.......)))))))).))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).))..)))....((((((...))))))....((((((.........))))))......((((.[[......((((.....((..]])).......))))..))))..).)))))))..........((([[...(.((((....((.(.(((((.(((((((((......(((((((.....)))))))....)))))))..))))))).)..(((((((.....(((((((((..(((((((....((........)).......)))))))..)).......((....)).)))))))....))).)))..)))....))))....((((((....(...((((.........))))...).))))))......{...((((((..((..((((((((((.....))))))))))..))...((..]])).....)))))))))).(((....].((((....))))....)))...]]]..((((...((((((..((.((((.(..((((((((((......((........))..........(((((.(...((((((......(((.(((.......))).)))...)).))))...((.(((...((.(((.(....((((((.((....))...((((......))))..))))))....(((((.(((((((.((......(((((....)))).)...)..))))))).).(..(((((....))))).....)..)))))....).).))....)).)))))....).)))))...)).)))))))).(...(((((((.....(.(..((..((.(...).))..))....)).....)))))))......(....(((((((........)))))))....)..)..).))))....((((((((.......))))))))......))...))))))..)).))..(.(..((.(.((((.(((..(((.(((((((((..(.((((.(((.....))).)))).)..))))))))).)))..))).))))..).))...)..)..(((((.(((....))).)))))}........... Cryo-EM Structures and Translocation Mechanism of Crenarchaeota Ribosome; 16S rRNA (1493-MER) 8hl5 A5S 122 5.72 RF00001 URS000056704D_330779 37604686 0003735 0005840 330779 ugcccacccggucauagugagcggguaacacccggacucguuucgaacccggaaguuaagccgcucacgucagaggggccgugggauccgagagggcccgcagccucucugagcugggaugg ..<<..<<<<<<....<<<<.<<<.....<<<<<...............>>>..>>....>>>.>>>>.<<<<..<<<<..<<<<..<<....>>.>>>>..>>>>..>>>>>>>>>>..>> ..((..((((......(((((((......((.(((...(.....)...)))...)).....))))))).((.(((((((...(((..((....)).)))...))))))).))..))))..)) Cryo-EM Structures and Translocation Mechanism of Crenarchaeota Ribosome; 5S rRNA (122-MER) 8hl5 AATN 76 5.72 RF00005 URS00005AA258_330779 37604686 0030533 0006412 330779 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<...<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>.>>>>>>.... ((((((...((((........)))).(((((.......))))).....((.((.......)).)).)))))).... Cryo-EM Structures and Translocation Mechanism of Crenarchaeota Ribosome; tRNA (76-MER) 8hl5 APTN 76 5.72 RF00005 URS00005AA258_330779 37604686 0030533 0006412 330779 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<...<<<<........>>>>.<<<<<<.....>>>>>>......<<<<.......>>>>..>>>>>>.... ((((((...((((.....[..)))).(((((.......))))).....((.((..]....)).)).)))))).... Cryo-EM Structures and Translocation Mechanism of Crenarchaeota Ribosome; tRNA (76-MER) 8hmz 5 45 2.9 URS00026813ED_9606 37028420 9606 gggcucuguggcgcaauggauagcgcauuggacuucuauagagcn ..........<<<<........>>>>........<<<..>>>... ..........((((........))))......(.((....))).. Cryo-EM structure of the human post-catalytic TSEN/pre-tRNA complex; Pre-tRNA 5' END 8hmz 3 37 2.9 URS00026813E6_9606 37028420 9606 auucaaagguuguggguucgaaucccaccagagucgg ...........<<<<<.......>>>>>......... ...........(((((.......)))))......... Cryo-EM structure of the human post-catalytic TSEN/pre-tRNA complex; Pre-tRNA 3' END 8hsp A 1519 2.32 RF00177,RF01959,RF02542,RF01960 38538915 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugccggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<...<<<<<<<<<......>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<.>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<..>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((((((......)))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((.(....).))))......)).).....(((....)))....((((((.)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....(((.((((.......)))).))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((((())))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...((.(((....))).)).....(.....)..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... E. coli 70S ribosome complexed with tRNA_Ile2 bearing L34 and t6A37 in classical state; 16S rRNA 8hsp a 2753 2.32 RF02541 38538915 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagcgucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcgcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<..>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<..>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.......<<<<<<.<<....>>..>>>>>>.......>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<..>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((..(((((.((.(((...(((((......)))))[[(...).(((.....]])))...)))...)).)))))..)))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((.((((.....))))..))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(())...)))..))))).))...........]]].)...))))))))))...)))))))((((((((()))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(...((((....))))....))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((())))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).).....((.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..))....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). E. coli 70S ribosome complexed with tRNA_Ile2 bearing L34 and t6A37 in classical state; 23S rRNA 8hsp b 119 2.32 RF00001 38538915 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>> ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))) E. coli 70S ribosome complexed with tRNA_Ile2 bearing L34 and t6A37 in classical state; 5S rRNA 8hsp V 76 2.32 RF00005 38538915 0030533 679895 guccccuucgucuagaggcccaggacaccgcccunucncggcgguaacaggggnucgaauccccuaggggacgcca <<<<<<<..<<<<.........>>>><<<<<<.......>>>>>>...<<<<<.......>>>>>>>>>>>>.... (((((((..(((.....[.....)))((((((.......))))))...(((((..]....)))))))))))).... E. coli 70S ribosome complexed with tRNA_Ile2 bearing L34 and t6A37 in classical state; P-site tRNA_Glu 8hsp W 11 2.32 38538915 562 acugagauaua ........... ........... E. coli 70S ribosome complexed with tRNA_Ile2 bearing L34 and t6A37 in classical state; mRNA 8hsp X 76 2.32 RF00005 38538915 0030533 679895 ggccccunagcucagungnnagagcaggcgacunaunaucgcuugnncgcuggnucaaauccagcaggggccacca <<<<<<<..<<<<........>>>><<<<<<.......>>>>>>....<<<<<.......>>>>>>>>>>>>.... (((((((..((((....[...))))(((((.........)))))....(((((..]....)))))))))))).... E. coli 70S ribosome complexed with tRNA_Ile2 bearing L34 and t6A37 in classical state; A-site tRNA_Ile2 8htz A 1519 2.4 RF00177,RF01959,RF02542,RF01960 38538915 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugccggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<......>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<.>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<..>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>.............>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((.(((((......)))))..)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((.)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((((.......)))))))).....)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((((())))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((.(((....))).)))....(.....)..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... E. coli 70S ribosome complexed with H. marismortui tRNA_Ile2 bearing agm2C34 in classical state; 16S rRNA 8htz a 2753 2.4 RF02541 38538915 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagcgucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcgcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<..>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<..>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<<.<<....>>..>>>>>>.>......>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<..>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.(((.(.....((((.(((((.((.(((...(((((......)))))[[(...).(((.....]])))...)))...)).))))).))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((..(((.....)))...))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(())...)))..))))).))...........]]].)...))))))))))...)))))))((((((((()))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...(((((.((((((.((.....)))))))).)..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((())))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). E. coli 70S ribosome complexed with H. marismortui tRNA_Ile2 bearing agm2C34 in classical state; 23S rRNA 8htz b 119 2.4 RF00001 38538915 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>> ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))) E. coli 70S ribosome complexed with H. marismortui tRNA_Ile2 bearing agm2C34 in classical state; 5S rRNA 8htz V 76 2.4 RF00005 38538915 0030533 679895 guccccuucgucuagaggcccaggacaccgcccunucncggcgguaacaggggnucgaauccccuaggggacgcca <<<<<<<..<<<<.........>>>><<<<<<.......>>>>>>...<<<<<.......>>>>>>>>>>>>.... (((((((..(((.....[.....)))((((((.......))))))...(((((..]....)))))))))))).... E. coli 70S ribosome complexed with H. marismortui tRNA_Ile2 bearing agm2C34 in classical state; P-site tRNA_Glu 8htz W 11 2.4 38538915 562 acugagauaua ........... ........... E. coli 70S ribosome complexed with H. marismortui tRNA_Ile2 bearing agm2C34 in classical state; mRNA 8htz X 78 2.4 38538915 2238 gggcccuuagcuuanucugguuaaagcnaucggcunaunaccgauugagngcuggnunnaauccggcagggcccacca <<<<<<<..<<<<..........>>>><<<<<<.......>>>>>>....<<<<<.......>>>>>>>>>>>>.... ((.((((..((((......[...))))((((((.......))))))....((.((..]....)).)))))).)).... E. coli 70S ribosome complexed with H. marismortui tRNA_Ile2 bearing agm2C34 in classical state; A-site tRNA_Ile2 8hu1 A 1519 2.69 RF00177,RF01959,RF02542,RF01960 38538915 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugccggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<......>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<.>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>...<.<<<<<.......<<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<..>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>.............>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<..<.<<<<<<<........>>>>>>>>...>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((((((......)))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((.)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((((())))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))....(.....)..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... E. coli 70S ribosome complexed with tRNA_Ile2 bearing L34 and ct6A37 in classical state; 16S rRNA 8hu1 a 2753 2.69 RF02541 38538915 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagcgucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcgcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<..>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<..>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<<..>>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<<.<<....>>..>>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<..>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((.((((((.((.(((...(((((......)))))[[(...).(((.....]])))...)))...)).)))))).)))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((.((((.....))))..))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(())...)))..))))).))...........]]].)...))))))))))...)))))))((((((((()))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((())))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).).....((.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..))....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). E. coli 70S ribosome complexed with tRNA_Ile2 bearing L34 and ct6A37 in classical state; 23S rRNA 8hu1 b 119 2.69 RF00001 38538915 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>> ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))) E. coli 70S ribosome complexed with tRNA_Ile2 bearing L34 and ct6A37 in classical state; 5S rRNA 8hu1 V 76 2.69 RF00005 38538915 0030533 679895 guccccuucgucuagaggcccaggacaccgcccunucncggcgguaacaggggnucgaauccccuaggggacgcca <<<<<<<..<<<<.........>>>><<<<<<.......>>>>>>...<<<<<.......>>>>>>>>>>>>.... (((((((..(((.....[.....)))((((((.......))))))...(((((..]....)))))))))))).... E. coli 70S ribosome complexed with tRNA_Ile2 bearing L34 and ct6A37 in classical state; P-site tRNA_Glu 8hu1 W 11 2.69 38538915 562 acugagauaua ........... ........... E. coli 70S ribosome complexed with tRNA_Ile2 bearing L34 and ct6A37 in classical state; mRNA 8hu1 X 76 2.69 RF00005 38538915 0030533 679895 ggccccunagcucagungnnagagcaggcgacunaunaucgcuugnncgcuggnucaaauccagcaggggccacca <<<<<<<..<<<<........>>>><<<<<<.......>>>>>>....<<<<<.......>>>>>>>>>>>>.... (((((((..((((....[...))))(((((.........)))))....(((((..]....)))))))))))).... E. coli 70S ribosome complexed with tRNA_Ile2 bearing L34 and ct6A37 in classical state; A-site tRNA_Ile2 8hzd A 36 1.87 38816645 32630 ggaagauuguaaacaugccgaaaggcagacacuucc <<<<<..........<<<<....>>>>....>>>>> (((((..........((((....))))....))))) A new fluorescent RNA aptamer bound with N618; RNA (36-MER) 8hzd B 36 1.87 38816645 32630 ngaagauuguaaacaugccgaaaggcagacacuucc <<<<<..........<<<<....>>>>....>>>>> (((((..........((((....))))....))))) A new fluorescent RNA aptamer bound with N618; RNA (36-MER) 8hze B 35 1.59 38816645 32630 gaagauuguaaacaugccgaaaggcagacacuucc <<<<..........<<<<....>>>>....>>>>. ((((..........((((....))))....)))). A new fluorescent RNA aptamer bound with N; RNA (36-MER) 8hzf A 35 2.7 38816645 32630 gaagauuguaaacaugccgaaaggcagacacuucc <<<<..........<<<<....>>>>....>>>>. ((((..........((((....))))....)))). A new fluorescent RNA aptamer bound with N565; RNA (36-MER) 8hzf B 35 2.7 38816645 32630 gaagauuguaaacaugccgaaaggcagacacuucc <<<<..........<<<<....>>>>....>>>>. ((((..........((((....))))....)))). A new fluorescent RNA aptamer bound with N565; RNA (36-MER) 8hzj A 35 2.6 38816645 32630 gaagauuguaaacaugccgaaaggcagacacuucc <<<<..........<<<<....>>>>....>>>>. ((((..........((((....))))....)))). A new fluorescent RNA aptamer bound with N571; RNA (36-MER) 8hzj B 35 2.6 38816645 32630 gaagauuguaaacaugccgaaaggcagacacuucc <<<<..........<<<<....>>>>....>>>>. ((((..........((((....))))....)))). A new fluorescent RNA aptamer bound with N571; RNA (36-MER) 8hzk A 36 2.0 38816645 32630 ggaagauuguaaacaugccgaaaggcagacacuucc <<<<<..........<<<<....>>>>....>>>>> (((((..........((((....))))....))))) A new fluorescent RNA aptamer bound with N, iridium hexammine soak; RNA (36-MER) 8hzk B 36 2.0 38816645 32630 ggaagauuguaaacaugccgaaaggcagacacuucc <<<<<..........<<<<....>>>>....>>>>> (((((..........((((....))))....))))) A new fluorescent RNA aptamer bound with N, iridium hexammine soak; RNA (36-MER) 8hzl A 84 2.6 38816645 32630 ggaagauuguaaacagcgagauuguaaacagcgagauuguaaacaugccgaaaggcagacacucgcgacacucgcgacacuuuc <<<<<..........<<<<<..........<<<<<..........<<<<....>>>>....>>>>>....>>>>>....>>>>> (((((..........(((((..........(((((..........((((....))))....)))))....)))))....))))) A new fluorescent RNA aptamer_III bound with N; RNA (84-MER) 8hzl B 84 2.6 38816645 32630 ggaagauuguaaacagcgagauuguaaacagcgagauuguaaacaugccgaaaggcagacacucgcgacacucgcgacacuuuc <<<<<..........<<<<<..........<<<<<..........<<<<....>>>>....>>>>>....>>>>>....>>>>> (((((..........(((((..........(((((..........((((....))))....)))))....)))))....))))) A new fluorescent RNA aptamer_III bound with N; RNA (84-MER) 8hzm A 35 2.5 38816645 32630 gaagauuguaaacaugccgaaaggcagacacuucc <<<<..........<<<<....>>>>....>>>>. ((((..........((((....))))....)))). A new fluorescent RNA aptamer bound with N, manganese soak; RNA (36-MER) 8hzm B 35 2.5 38816645 32630 gaagauuguaaacaugccgaaaggcagacacuucc <<<<..........<<<<....>>>>....>>>>. ((((..........((((....))))....)))). A new fluorescent RNA aptamer bound with N, manganese soak; RNA (36-MER) 8i0p B 98 3.4 RF00020 39068178 0000244,0000353 0005682,0046540 9606 gguuucucuucagaucgcauaaaucuuucgccuuuuacuaaagauuuccguggagaggaacaaccccaauuuuuugaggccuugcuuuggcaaggcua .<<<<<<<<<<<........<<<<<<<<.<.......>.>>>>>>>>...>>>>>>>>>>>................<<<<<<<<....>>>>>>>>. .(((.((((.((....(...((((((((.(.......).)))))))).).)).)))).))).................(((((((....))))))).. The cryo-EM structure of human pre-Bact complex; U5 snRNA 8i0p F 95 3.4 RF00026 URS00001EC8D7_9606 39068178 0030621 0000244,0000353 0005688,0046540 9606 gugcucgcuucggcagcacauauacuaaaauuggaacgauacagagaagauuagcauggccccugcgcaaggaugacacgcaaauucgugaagcg <<<<<.<<<..>>>>>>>>..........................................<<<.....>>>....................... (((((.((....))))))).....................................(....(((.....))).....)................. The cryo-EM structure of human pre-Bact complex; U6 snRNA 8i0p G 63 3.4 39068178 10535 cuccgaacgguaagagccuagcauguagaaugaugucauacuuauccugucccuuuuuuuucc ............................................................... ............................................................... The cryo-EM structure of human pre-Bact complex; pre-mRNA 8i0p H 165 3.4 RF00004 39068178 0045131 0000348 0005686 9606 cgcuucucggccuuuuggcuaagaucaaguguaguaucuguucuuaucaguuuaauaucugauguccucucgaggacggauuuuuggagcagggagauggaauaggagcuugcuccguccacuccacgcaucgaccugguauugcaguaccuccaggaacggugc ..............................................<<<<........>>>>..<<<<<..>>>>>................<<<..<<<<...<<<<....>>>>.>>>>.>>>..<<<<<<.<<<<<.............>>>>>..>>>>>> ...............................................(((........)))..(.((((..)))).)...............(((..(((....((((....))))..))).)))..(((.((..((((.............))))...)).))) The cryo-EM structure of human pre-Bact complex; U2 snRNA 8i0r B 98 3.0 RF00020 39068178 0000244,0000353 0005682,0046540 9606 gguuucucuucagaucgcauaaaucuuucgccuuuuacuaaagauuuccguggagaggaacaaccccaauuuuuugaggccuugcuuuggcaaggcua .<<<<<<<<<<<........<<<<<<<<.<.......>.>>>>>>>>...>>>>>>>>>>>................<<<<<<<<....>>>>>>>>. .(((.(((((((....(...((((((((.(.......).)))))))).).))))))).))).................(((((((....))))))).. The cryo-EM structure of human Bact-I complex; U5 snRNA 8i0r F 97 3.0 RF00026 39068178 0030621 0000244,0000353 0005688,0046540 9606 gugcucgcuucggcagcacauauacuaaaauuggaacgauacagagaagauuagcauggccccugcgcaaggaugacacgcaaauucgugaagcguu <<<<<.<<....>>>>>>>.....................................<<...<<<.....>>>....>>................... (((((.((....))))))).....................................((..((((.....)))..).))................... The cryo-EM structure of human Bact-I complex; U6 snRNA 8i0r G 71 3.0 39068178 10535 cggccuccgaacgguaagagccuagcauguagaacugaugaugucauacuuauccugucccuuuuuuuucc ....................................................................... ....................................................................... The cryo-EM structure of human Bact-I complex; pre-mRNA 8i0r H 167 3.0 RF00004 39068178 0045131 0000348 0005686 9606 aucgcuucucggccuuuuggcuaagaucaaguguaguaucuguucuuaucaguuuaauaucugauguccucucgaggacggauuuuuggagcagggagauggaauaggagcuugcuccguccacuccacgcaucgaccugguauugcaguaccuccaggaacggugc ................................................<<<<........>>>>..<<<<<..>>>>>................<<<..<<<....<<<<....>>>>..>>>.>>>..<<<<<<.<<<<<.............>>>>>..>>>>>> .................................................(((........)))..(.((((..)))).)...............((...(((....((((....))))..)))..))..(((.((..((((.............))))...)).))) The cryo-EM structure of human Bact-I complex; U2 snRNA 8i0s B 98 4.2 RF00020 39068178 0000244,0000353 0005682,0046540 9606 gguuucucuucagaucgcauaaaucuuucgccuuuuacuaaagauuuccguggagaggaacaaccccaauuuuuugaggccuugcuuuggcaaggcua .<<<<<<<<<<<........<<<<<<<<...........>>>>>>>>...>>>>>>>>>>>................<<<<<<<<....>>>>>>>>. .(((.(((((((....(...((((((((.(.......).)))))))).).))))))).))).................(((((((....))))))).. The cryo-EM structure of human Bact-II complex; U5 snRNA 8i0s F 97 4.2 RF00026 39068178 0030621 0000244,0000353 0005688,0046540 9606 gugcucgcuucggcagcacauauacuaaaauuggaacgauacagagaagauuagcauggccccugcgcaaggaugacacgcaaauucgugaagcguu <<<<<.<......>>>>>>.....................................<<...<<<.....>>>....>>................... (((((.((....))))))).....................................((..((((.....)))..).))................... The cryo-EM structure of human Bact-II complex; U6 snRNA 8i0s G 72 4.2 39068178 10535 cggccuccgaacgguaagagccuagcauguagaacugaugaugucauacuuauccugucccuuuuuuuucca ........................................................................ ........................................................................ The cryo-EM structure of human Bact-II complex; pre-mRNA 8i0s H 167 4.2 RF00004 39068178 0045131 0000348 0005686 9606 aucgcuucucggccuuuuggcuaagaucaaguguaguaucuguucuuaucaguuuaauaucugauguccucucgaggacggauuuuuggagcagggagauggaauaggagcuugcuccguccacuccacgcaucgaccugguauugcaguaccuccaggaacggugc ................................................<<<<........>>>>.<<<<<<..>>>>>>...............<<<<.<<<<...<<<<....>>>>.>>>>>>>>..<<<<<<.<<<<<.............>>>>>..>>>>>> .................................................(((........)))..(.((((..)))).)...............(((..((((...((((....)))).)))).)))..(((.((..((((.............))))...)).))) The cryo-EM structure of human Bact-II complex; U2 snRNA 8i0t B 98 3.0 RF00020 39068178 0000244,0000353 0005682,0046540 9606 gguuucucuucagaucgcauaaaucuuucgccuuuuacuaaagauuuccguggagaggaacaaccccaauuuuuugaggccuugcuuuggcaaggcua .<<<<<<<<<<<........<<<<<<<<...........>>>>>>>>...>>>>>>>>>>>................<<<<<<<<....>>>>>>>>. .(((.(((((((....(...((((((((.(.......).)))))))).).))))))).))).................(((((((....))))))).. The cryo-EM structure of human Bact-III complex; U5 snRNA 8i0t F 97 3.0 RF00026 39068178 0030621 0000244,0000353 0005688,0046540 9606 gugcucgcuucggcagcacauauacuaaaauuggaacgauacagagaagauuagcauggccccugcgcaaggaugacacgcaaauucgugaagcguu <<<<<.<......>>>>>>.....................................<<...<<<.....>>>....>>................... (((((.((....))))))).....................................((..((((.....)))..).))................... The cryo-EM structure of human Bact-III complex; U6 snRNA 8i0t G 72 3.0 39068178 10535 cggccuccgaacgguaagagccuagcauguagaacugaugaugucauacuuauccugucccuuuuuuuucca ........................................................................ ........................................................................ The cryo-EM structure of human Bact-III complex; Pre-mRNA 8i0t H 167 3.0 RF00004 39068178 0045131 0000348 0005686 9606 aucgcuucucggccuuuuggcuaagaucaaguguaguaucuguucuuaucaguuuaauaucugauguccucucgaggacggauuuuuggagcagggagauggaauaggagcuugcuccguccacuccacgcaucgaccugguauugcaguaccuccaggaacggugc ................................................<<<<........>>>>.<<<<<<..>>>>>>...............<<<<.<<<<...<<<<....>>>>.>>>>>>>>..<<<<<<.<<<<<.............>>>>>..>>>>>> .................................................(((........)))..(.((((..)))).)...............(((..((((...((((....)))).)))).)))..(((.((..((((.............))))...)).))) The cryo-EM structure of human Bact-III complex; U2 snRNA 8i0u B 98 3.3 RF00020 39068178 0000244,0000353 0005682,0046540 9606 gguuucucuucagaucgcauaaaucuuucgccuuuuacuaaagauuuccguggagaggaacaaccccaauuuuuugaggccuugcuuuggcaaggcua .<<<<<<<<<<<........<<<<<<<<...........>>>>>>>>...>>>>>>>>>>>................<<<<<<<<....>>>>>>>>. .(((.(((((((....(...((((((((.(.......).)))))))).).))))))).))).................(((((((....))))))).. The cryo-EM structure of human Bact-IV complex; U5 snRNA 8i0u F 97 3.3 RF00026 39068178 0030621 0000244,0000353 0005688,0046540 9606 gugcucgcuucggcagcacauauacuaaaauuggaacgauacagagaagauuagcauggccccugcgcaaggaugacacgcaaauucgugaagcguu <<<<<.<<....>>>>>>>.....................................<<...<<<.....>>>....>>................... (((((.((....))))))).....................................((..((((.....)))..).))................... The cryo-EM structure of human Bact-IV complex; U6 snRNA 8i0u G 79 3.3 39068178 9606 cggccuccgaacgguaagagccuagcauguagaacugguuaccuaugaugucauacuuauccugucccuuuuuuuucca ............................................................................... ............................................................................... The cryo-EM structure of human Bact-IV complex; Pre-mRNA 8i0u H 167 3.3 RF00004 39068178 0045131 0000348 0005686 9606 aucgcuucucggccuuuuggcuaagaucaaguguaguaucuguucuuaucaguuuaauaucugauguccucucgaggacggauuuuuggagcagggagauggaauaggagcuugcuccguccacuccacgcaucgaccugguauugcaguaccuccaggaacggugc ................................................<<<<........>>>>.<<<<<<..>>>>>>...............<<<<.<<<<...<<<<....>>>>.>>>>>>>>..<<<<<<.<<<<<.............>>>>>..>>>>>> .................................................(((........)))..(.((((..)))).)...............(((..((((...((((....)))).)))).)))..(((.((..((((.............))))...)).))) The cryo-EM structure of human Bact-IV complex; U2 snRNA 8i0v B 98 3.0 RF00020 39068178 0000244,0000353 0005682,0046540 9606 gguuucucuucagaucgcauaaaucuuucgccuuuuacuaaagauuuccguggagaggaacaaccccaauuuuuugaggccuugcuuuggcaaggcua .<<<<<<<<<<<........<<<<<<<<...........>>>>>>>>...>>>>>>>>>>>................<<<<<<<<....>>>>>>>>. .(((.(((((((....(...((((((((.(.......).)))))))).).))))))).))).................(((((((....))))))).. The cryo-EM structure of human post-Bact complex; U5 snRNA 8i0v F 97 3.0 RF00026 39068178 0030621 0000244,0000353 0005688,0046540 9606 gugcucgcuucggcagcacauauacuaaaauuggaacgauacagagaagauuagcauggccccugcgcaaggaugacacgcaaauucgugaagcguu <<<<<.<<....>>>>>>>.....................................<<...<<<.....>>>....>>................... (((((.((....))))))).....................................((..((((.....)))..).))................... The cryo-EM structure of human post-Bact complex; U6 snRNA 8i0v G 79 3.0 39068178 9606 cggccuccgaacgguaagagccuagcauguagaacugguuaccuaugaugucauacuuauccugucccuuuuuuuucca ............................................................................... ............................................................................... The cryo-EM structure of human post-Bact complex; Pre-mRNA 8i0v H 151 3.0 RF00004 39068178 0045131 0000348 0005686 9606 aucgcuucucggccuuuuggcuaagaucaaguguaguaucuguuuaucaguuuaauaucugauggauuuuuggagcagggagauggaauaggagcuugcuccguccacuccacgcaucgaccugguauugcaguaccuccaggaacggugc ..............................................<<<<........>>>>................<<<<.<<<<...<<<<....>>>>.>>>>>>>>..<<<<<<.<<<<<.............>>>>>..>>>>>> ...............................................(((........))).................(((..((((...((((....)))).)))).)))..(((.((..((((.............))))...)).))) The cryo-EM structure of human post-Bact complex; U2 snRNA 8i0w B 98 3.4 RF00020 39068178 0000244,0000353 0005682,0046540 9606 gguuucucuucagaucgcauaaaucuuucgccuuuuacuaaagauuuccguggagaggaacaaccccaauuuuuugaggccuugcuuuggcaaggcua .<<<<<<<<<<<........<<<<<<<<...........>>>>>>>>...>>>>>>>>>>>................<<<<<<<<....>>>>>>>>. .(((.(((((((....(...((((((((.(.......).)))))))).).))))))).))).................(((((((....))))))).. The cryo-EM structure of human C complex; U5 snRNA 8i0w F 97 3.4 RF00026 39068178 0030621 0000244,0000353 0005688,0046540 9606 gugcucgcuucggcagcacauauacuaaaauuggaacgauacagagaagauuagcauggccccugcgcaaggaugacacgcaaauucgugaagcguu <<<<<.<<<..>>>>>>>>.....................................<<...<<<.....>>>....>>................... (((((.((....))))))).....................................((..((((.....)))..).))................... The cryo-EM structure of human C complex; U6 snRNA 8i0w G 18 3.4 39068178 10535 ggaaccggccuccgaacg .................. .................. The cryo-EM structure of human C complex; pre-mRNA 8i0w 6 70 3.4 39068178 10535 guaagagccuagcauguagaacugguuaccuccaggguuuccuugaugaugucauacuuauccugucccu ...................................................................... ...................................................................... The cryo-EM structure of human C complex; pre-mRNA 8i0w H 139 3.4 RF00004 URS00003EE995_9606 39068178 0045131 0000348 0005686 9606 aucgcuucucggccuuuuggcuaagaucaaguguaguaucuguucuuuuaauauguccucuaccgaggacaauauuaaggauuuuuggagcagggagccacgcaucgaccugguauugcaguaccuccaggaacggugc ...............................................<<<<<<<<<<<<<....>>>>>>.>>>>>>>...............<......><<<<<<.<<<<<.............>>>>>..>>>>>> ...............................................(((((((((((((....)))))).)))))))...............(..()..)(((.((.(((((.............)))))..)).))) The cryo-EM structure of human C complex; U2 snRNA 8i3z A 24 1.67 URS00026813CC_1318 36840714 1318 agagcguugcguccgaaagungcc ........................ ........................ Crystal structure of NAD-II riboswitch (two strands) with NMN at 1.67 angstrom; RNA (5'-R(*AP*GP*AP*GP*CP*GP*UP*UP*GP*CP*GP*UP*CP*CP*GP*AP*AP*AP*GP*UP*(CBV)P*GP*CP*C)-3') 8i3z B 31 1.67 URS00026813C0_1318 36840714 1318 gcgacacggcucuuuaaaaacaaaaggagaa ............................... ............................... Crystal structure of NAD-II riboswitch (two strands) with NMN at 1.67 angstrom; RNA (31-MER) 8i9p C1 1307 3.0 RF02543 URS00026813FF_759272 37129998 0003735 0005840 759272 uugaccucggaucagguaggaggacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaacagggauugcccuaguaacggcgagugaagcggcaacagcucaaauuugaaagcuggcuucggcccgcguuguaauuuggagaggaugcuuugggcgaggcuccuucugaguucccuggaacgggacgccacagagggugagagccccguauaguuggaagccaagccuguguaaagcuccuucgacgagucgaguaguuugggaaugcugcucaaaaugggagguaaauuucuucuaaagcuaaauaccggccagagaccgauagcgcacaaguagagugaucgaaagaugaaaagcacuuugaaaagaggguuaaauagcacgugaaauuguugaaagggaagcgcuugugaccagacuugcgcccggcggaucauccgguguucucaccggugcacuccgccgggcucaggccagcaucgguucuggcggggggauaaaggcccagggaauguggcuccuccgggaguguuauagcccuggguguaauacccucgccgggaccgaggaccgcgcucugcaaggaugcuggcguaauggucaccagcgacccgucuugaaacacggaccaaggagucaagguuuugcgcgaguguuuggguguaaaacccgcacgcguaaaggugagagcuucggcgcaucaucgaccgauccugauguauucggauggauuugaguaggagcguuaagccuuggacccgaaagauggugaacaaccaucuaguagcugguuaccgccgaaguuucccucaggauagcagugucgaccuucaguuuuaugagguaaagcgaaugaacuuuaaauauguaagaagcccuuguuacuuaacugaacgugggcauucgaauguaucgacacuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacgcgggguuaaggugccggaguggacgcucaucagacuggcgcucaagcgucccacccauaccccgcccucaggguagaaacgaugcccugaggaguaggcggccguggaggucagugacgaagccuagggcgugagcccgggucgaacggccucuagugcagaucuuggugguaguagcaaauaucuagcgaaaccacagacccgcacguagacguauaagaauaggcuccggccucguauccuagcaggcgauuccuccgccggccucgaaguggccgucgguaauucgcguauugcaaagacacgcgcgggaucaaaucagauuuc ........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..<<<..<<.......<<.<<<....>>>.>>.......>>....<<<<<.<<<<<<<<<..<<<<<<..<<....<<<<......>>>>.((......<<<.....))>>>....>>..>>>.>>>..>>>>....>>>>>>>>.>>........<<<<<<<........>>>>>>>.....<<<<<<......>>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<.<<<<<<<....<<.<<<<<<<<<<.<<.<<<<<<....>>>>>>>>...>>>>>>>>>>.>>.<<<<<<<.<<<<<<<<<<<<<<<.......<<<<<<<<......<<<<<....>>>>>.......>>>>>>>>......>>>>>>>>>>>>>>>........<<...>>.....>>>>>>>....>>>>>>>.>>>>..<<<<.<....>.>>>><<<<<<...<<<<<<<<<.<<<<..<<<...<<<<.....>>>>...>>>.....<<<<<..<<....>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>.>>>>>>>>>.<<.<..<<<<<<<.....>>>>>>...>..>.>>...<<<<<....<.<<<....>>>.><<<<<<<<<<....<<.<<<<<<......<<<........>>.>......>>>>...<<<..<<<<.<......>>>>>.>>.>.....>>>>..>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<...))).>>...>>>>>>.>>>...>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.........>>....>>.....<<<<<.<<.......<<.......<<<....>>>....>>........<<<<.....<<<.<<<<<.......>>>>>.>>>....>>>>..............>>.>>>>>...<<<<<.>>>>>. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.(((....))).))....)........(((((.(((((((((..((((((..((..({((((......)))))[[(...).(((....}]])))....))..))).)))..))))....)))))))).))...)....(((((((........))))))).....(((((........)))))..)))..................................((....))............(..((((....))))............).....................((((.(((((((.....(.((((((((((.((.((((((....))))))))...)))))))))).)..(((((((((((((((((((((((.......((((((((......(((((....))))).......))))))))......)))))))))))))))........((...))....))))))))....))))))).))))..((((........))))((((((..(.((((((((.((((..(((...(((.......)))...))).....(((((..((....))...))))).(((.((((....(....)....))).).).))....)))).))))))))..((.(...((((((.....))))))......).)))..(((((....(.(((....))).)((((((((((....((.(((((.......(((........)).).......)))...(((..((((.(......))))).).)).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(...]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.........))....)).....(((((.((.....(.((.......(((....)))....))).......((((.....(((.(((((.......))))).)))....))))..............)).)))))...(((((.))))). Cryo-EM structure of a Chaetomium thermophilum pre-60S ribosomal subunit - State Mak16; RNA (3341-MER) 8i9p C2 256 3.0 RF00002 URS0002681403_759272 37129998 0003735 0005840 759272 aaacuuucaacaacggaucucuugguucuggcaucgaugaagaacgcagcgaaaugcgauaaguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgcccgccgguauuccggcgggcaugccuguucgagcgucauuucaaccaucaagcccugggcuuguguuggggacccgcggcugcucgcgggcccugaaaagcaguggcgggcucgcuggcgggugccagccguaaaaccc .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>............................<<<<<<...>>>>>>....<<<<.<<<<<<<....>>>>>>>>>>>.........<<<<<<<<<<<<..>>>>>>.>>.>>>>........ .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))............................((((((...))))))...(((((.((((((......))))))))))..).......(((((((((((())))))).)).)))......... Cryo-EM structure of a Chaetomium thermophilum pre-60S ribosomal subunit - State Mak16; RNA (306-MER) 8i9r C1 2048 3.1 RF02543 URS00026813FF_759272 37129998 0003735 0005840 759272 uugaccucggaucagguaggaggacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaacagggauugcccuaguaacggcgagugaagcggcaacagcucaaauuugaaagcuggcuucggcccgcguuguaauuuggagaggaugcuuugggcgaggcuccuucugaguucccuggaacgggacgccacagagggugagagccccguauaguuggaagccaagccuguguaaagcuccuucgacgagucgaguaguuugggaaugcugcucaaaaugggagguaaauuucuucuaaagcuaaauaccggccagagaccgauagcgcacaaguagagugaucgaaagaugaaaagcacuuugaaaagaggguuaaauagcacgugaaauuguugaaagggaagcgcuugugaccagacuugcgcccggcggaucauccgguguucucaccggugcacuccgccgggcucaggccagcaucgguucuggcggggggauaaaggcccagggaauguggcuccuccgggaguguuauagcccuggguguaauacccucgccgggaccgaggaccgcgcucugcaaggaugcuggcguaauggucaccagcgacccgucuugaaacacggaccaaggagucaagguuuugcgcgaguguuuggguguaaaacccgcacgcguaaaggugagagcuucggcgcaucaucgaccgauccugauguauucggauggauuugaguaggagcguuaagccuuggacccgaaagauggugaacuaugcuugagcaugggggcgaaagacuaaucgaaccaucuaguagcugguuaccgccgaaguuucccucaggauagcagugucgaccuucaguuuuaugagguaaagcuuuaaauauguaagaagcccuuguuacuuaacugaacgugggcauucgaauguaucgacacuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacgcgggguuaaggugccggaguggacgcucacaaaaggcguuaguacaucuuauguacuagcccugggcgcucaagcgucccacccauaccccgcccucaggguagaaacgaugcccugaggaguaggcggccguggaggucagugacgaagccuagggcgugagcccgggucgaacggccucuagugcagaucuuggugguaguagcaaauacuucaaugagaaggugaacagccucugugauagaacaauguagauaagggaagucacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcaaaaucagcggggaagacccuguugagcuugacucuaguuugacauugugaaaagacauaggagguguagaauaggugggagcuucggcgccagugaaauaccacuacuccuauuguuuuuuuacuuauucaaugugaagacauugucagguggggaguuggcggcacaucugugcagguguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaaguccccuugauuuugauunucagngngaauacaaaccaugaaaguguggccuccuuuagucccucgaaauuugaggcuagaggagaaaaguuaccacagggaugaccgucgugagacagguuaguucccuacugauacucgucgcaaugguaauucagcuuaguacgagaggaaccgcugauucagauaauugguuuuugcgguuguccgaccgggcagugccgcgaagcuaccaucugcuggauuccaugccagaacgcgacgauaacccgcacgguagacguauaagaauaggcuccggccucguauccuagcaggcgauuccuccgccggccucgaaguggccgucgguaauucgcguauugcaauuuagacacgcgcgggaucaaauccuuugcagacgacuuagaugugcgaaaggguccuguaagcaguagaguagccuuguuguuacgaucugcugaggguaagcccuccuucgccuagauuuc .........................<<<<<.....<......>......>>>>>...........<<....>>..<<<<<......<<.....>>.....>>>>>..<<<..<<.......<<.<<<....>>>.>>.......>>....<<<<<.<<<<<<<<<..<<<<<<..<<....<<<<......>>>>.((......<<<.....))>>>....>>..>>>.>>>..>>>>....>>>>>>>>.>>........<<<<<<<........>>>>>>>.....<<<<<<......>>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<.<<<<<<<....<<.<<<<<<<<<<.<<.<<<<<<....>>>>>>>>...>>>>>>>>>>.>>.<<<<<<<.<<<<<<<<<<<<<<<.......<<<<<<<<......<<<<<....>>>>>.......>>>>>>>>......>>>>>>>>>>>>>>>........<<...>>.....>>>>>>>....>>>>>>>.>>>>..<<<<........>>>><<<<<<...<<<<<<<<<.<<<<..<<<...<<<<.....>>>>...>>>.....<<<<<..<<....>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>.>>>>>>>>>.<<.<..<<<<<<<...<<<<<<<..>>>>>.>>..<<<..(((((.>>>.>>>>>>...>..>.>>...<<<<<......<<<....>>>..<<<<<<<<<<....<<.<<<<<<<.<.<.........>.>.>>>>>....<<..<<<<.<......>>>>>.>>.......>>>>..>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.......<<<..<<<<<<<<<...>>>>>>>>>.>>>.)))......>>>>>>.>>>...>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.......<<<..<<<............>>>..>>><<<<.....<<<<<<.<<<<<<<<.>>>.>>>>>>>>>>>..>>>>>>....>>.(..<<<<<......).>>>>>......<<<.<<......<<<<<<.<<<<<<.<<<<<..<<<<<<<..<<<<<<<<<<<<<<<<<..........<<<<<......................>>>>>.>>>>>>>.>>>>>>>>>>...<<<<...>>>>.....>>>>>>>...>>>>>.<<<...<<<<<<<..>>>>>>>.....<<<<<<<...<<<<<<.......>>>>>>.....<<......>>....>>>>>>>....<<<<.<.<<<.....>>>.>>>>>.<<<....>>>..>>>.<<<<<<<..<<<<<<...>>>>>>>>>>>>>....>>>>>.>.>>>>>>....<<<<<....>>>.>>.))))).>>..>>>....<<<<<<<..<<<<...<<<<<.................>>>>>..<<<<<...<<<<.<<<<<<<<<<<<<....>>>>>..>>>>>>>>>>>>..>>>>>.<<<<.>>>>.>>>>....>>>>>>>...<<<<<...<<......<<.......<<<<..>>>>....>>........<<<<.....<<<.<<<<<.......>>>>>.>>>....>>>>..............>>....>>>>>...<<<<<<<.............>>....<<<<<<<<<.<<<....<<<<.<..<<<<<......>>>>>..>>>>>...>>>....>>>>..>>>>>...>>>>>. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.(((....))).))....)........(((((.(((((((((..((((((..((..({((((......)))))[[(...).(((....}]])))....))..))).)))..))))....)))))))).))...)....(((((((........))))))).....(((((........)))))..)))..................................((....))............(..((((....))))............).....................((((.(((((((.....(.((((((((((.((.((((((....))))))))...)))))))))).)..(((((((((((((((((((((((.......((((((((......(((((....))))).......))))))))......)))))))))))))))........((...))....))))))))....))))))).))))..((((........))))((((((..(.((((((((.((((..(((...(((.......)))...))).....(((((..((....))...))))).((((((((....(....)....))).))).))....)))).))))))))..((.(...((((((...(.(((((())))))..)..((.(..[[[[.))).))))))......).)))..(((((....(.(((....))).)((((((((((....((.(((((((...(.(.....).)...)))))....(((.((((.(......))))).)))......))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((.......(((..(((((((((...))))))))).))).]]]......))))))))))...)))))))(((((((((.........)))))))))....))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.......(((..(((............)))..)))((((.....((((((.((((((((.))).)))))))))))..))))))....)).[..(((((......].)))))....(.(...((......((((((.((((((.(((((.(..(((((.((((((((.((.((((((.......[...((((..(......)..........].))))..))))))..)).)))))))...((((...))))...).)))))..)..))))).((.....((.((....)).))......(((((((.(.((((((.......))))))...).((......))....)))))))....((((.(.(((.....))).))))).(((....)))...)).(((((((..((((((...)))))))))))))....))))).).))))))....(((((....))).)).]]]]..))....).)..(((((((..(((((..(.(((......(....).....))).)..(((((...((((.((.((((.((.((....)).))...)))).))))))..))))).((((.)))))))))....)))))))...((((..(.((....(.((.......(((....)))....))).......((((.....(((.(((((.......))))).)))....))))..............))..)..))))...(((((((..(.......)..))..(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....))))..))))))..))))). Cryo-EM structure of a Chaetomium thermophilum pre-60S ribosomal subunit - State 5S RNP; RNA (3341-MER) 8i9r C2 228 3.1 RF00002 URS0002681402_759272 37129998 0003735 0005840 759272 aaacuuucaacaacggaucucuugguucuggcaucgaugaagaacgcagcgaaaugcgauaaguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcagcgcccgccgguauuccggcgggcaugccuguucgagcgucauuucaaccaucaagcccugggcuuguguuggggacccgcggcugcucgcgggcccugaaaagcaguggcgggcucgc .........................................<<<<<<.<<.....>>>.....(.<<<(.....>>............).>>>..)...>>>....<<.>><<<<<<<<<....>>>>>>>>>............................<<<<<<...>>>>>>....<<<<.<<<<<<<....>>>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.))(((((((((....)))))))))............................((((((...))))))...(((((.((((((......))))))))))..).................. Cryo-EM structure of a Chaetomium thermophilum pre-60S ribosomal subunit - State 5S RNP; RNA (256-MER) 8i9t C1 2132 3.6 RF02543 URS00026813FF_759272 37129998 0003735 0005840 759272 uugaccucggaucagguaggaggacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaacagggauugcccuaguaacggcgagugaagcggcaacagcucaaauuugaaagcuggcuucggcccgcguuguaauuuggagaggaugcuuugggcgaggcuccuucugaguucccuggaacgggacgccacagagggugagagccccguauaguuggaagccaagccuguguaaagcuccuucgacgagucgaguaguuugggaaugcugcucaaaaugggagguaaauuucuucuaaagcuaaauaccggccagagaccgauagcgcacaaguagagugaucgaaagaugaaaagcacuuugaaaagaggguuaaauagcacgugaaauuguugaaagggaagcgcuugugaccagacuugcgcccggcggaucauccgguguucucaccggugcacuccgccgggcucaggccagcaucgguucuggcggggggauaaaggcccagggaauguggcuccuccgggaguguuauagcccuggguguaauacccucgccgggaccgaggaccgcgcucugcaaggaugcuggcguaauggucaccagcgacccgucuugaaacacggaccaaggagucaagguuuugcgcgaguguuuggguguaaaacccgcacgcguaaugaaagugaacguaggugagagcuucggcgcaucaucgaccgauccugauguauucggauggauuugaguaggagcguuaagccuuggacccgaaagauggugaacaaccaucuaguagcugguuaccgccgaaguuucccucaggauagcagugucgaccuucaguuuuaugagguaaagcgaaugaacuuuaaauauguaagaagcccuuguuacuuaacugaacgugggcauucgaauguaucgacacuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacgcgggguuaaggugccggaguggacgcucaucagacaccacaaaaggcguuaguacaucuugacagcaggacgguggccauggaagucggaauccgcuaaggacuguguaacaacucaccugccgaauguacuagcccugaaaauggauggcgcucaagcgucccacccauaccccgcccucaggguagaaacgaugcccugaggaguaggcggccguggaggucagugacgaagccuagggcgugagcccgggucgaacggccucuagugcagaucuuggugguaguagcaaauuugauagaacaauguagauaagggaagucggcgggaaucugcgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcaaaaucagcggggaagacccuguugagcuugacucuaguuugacauugugaaaagacauaggagguguagaauaggugggagcuucggcgccagugaaauaccacuacuccuauuguuuuuuuacuuauucaaugugaagacauugucagguggggaguuccuuuagucccucgaaauuugaggcuagaggagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuuggaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacguggaccgucgugagacagguuagucccuacugaugaacucgucgcaaugguaauucagcuuaguacgagaggaaccgcugauucagauaauugguuuuugcgguuguccgaccgggcagugccgcgaagcuaccaucugcuggauaauggcugaacgccucuaagucagaauccaugccagaacgcgacgauaacccgcacguagacguauaagaauaggcuccggccucguauccuagcaggcgauuccuccgccggccucgaaguggccgucgguaauucgcguauugcaaagacacgcgcgggaucaaauccuuugcagacgacuuagaugugcgaaaggguccuguaagcaguagaguagccuuguuguuacgaucugcugaggguaagcccuccuucgccuagauuuc ........................<<<<<<.....<......>......>>>>>.>...<.....<<....>>..<<<<<......<<.....>>.....>>>>>..<<<..<<.......<<.<<<....>>>.>>.......>>....<<<<<.<<<<<<<<<..<<<<<<..<<....<<<<......>>>>.((......<<<.....))>>>....>>..>>>.>>>..>>>>....>>>>>>>>.>>........<<<<<<<........>>>>>>>.....<<<<<<......>>>>>>..>>>....>.............................<<....>>...............<<<<....>>>>..................................<<<<.<<<<<<<....<<.<<<<<<<<<<.<<.<<<<<<....>>>>>>>>...>>>>>>>>>>.>>.<<<<<<<.<<<<<<<<<<<<<<<.....<.<<<<<<<<......<<<<<....>>>>>.......>>>>>>>>....>.>>>>>>>>>>>>>>>........<<...>>.....>>>>>>>....>>>>>>>.>>>>..<<<<.<....>.>>>><<<<<<...<<<<<<<<<.<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<....>>...>>>>>.<<<<<<<<....<....>....>>>.>>>.>>....>>>>.>>>>>>>>>.<<.<..<<<<<<<.....>>>>>>...>..>.>>...<<<<<....<.<<<....>>>.><<<<<<<<<<....<<.<<<<<<<.....<<<........>>.>.....>>>>>....<<..<<<<.<......>>>>>.>>.......>>>>..>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>...>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<.........<<<<.....<<<<<<.<<<<<<<<....<<<<<<<<<>>.>>>>>>>>>>.>>>>>>>>>>>..>>>>.>....>>....<<<<<........>>>>>....<<<<<.<<<.....<<<<<<.<<<<<<.<<<<<..<<<<<<<..<<<<<<<<<<<<<<<<<..........<<<<<......................>>>>>.>>>>>>>.>>>>>>>>>>...<<<<...>>>>.....>>>>>>>...>>>>>.<<<<<<<..<<<<<<...>>>>>>>>>>>>>....>>>>>.>.>>>>>>.............<<<<<<...<<.......>>...>>>>>>.....((........<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.....))..>>>.....>>>>>..>..<<<<<<<....>>>.>>>>....>>>.>>>>>....<<<<<<<..<<<<.<.<<<<<.................>>>>>.><<<<<...<<<<...<<<<<<<<<<<....>>>>>..>>>>>>..>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>...<<<<<.<<.......<<.......<<<....>>>....>>........<<<<.....<<<.<<<<<.......>>>>>.>>>....>>>>..............>>.>>>>>...<<<<<<<.............>>....<<<<<<<<<.<<<....<<<<.<..<<<<<......>>>>>..>>>>>...>>>....>>>>..>>>>>...>>>>>. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.(((....))).))....)........(((((.(((((((((..((((((..((..({((((......)))))[[(...).(((....}]])))....))..))).)))..))))....)))))))).))...)....(((((((........))))))).....(((((........)))))..)))..................................((....))............(..((((....))))............).....................((((.(((((((.....(.((((((((((.((.((((((....))))))))...)))))))))).)..(((((((((((((((((((((((.......((((((((......((((......)))).......))))))))......)))))))))))))))........((...))....))))))))....))))))).))))..((((........))))((((((....((((((((.((((..(((...(((.......)))...)))...((....)).......(((((..((....))...))))).((((((((....(....)....))).))).))....)))).))))))))..((.(...((((((.....))))))......).))...(((((....(.(((....))).)((((((((((....((.(((((((.....(((........)).).....)))))....((..((((.(......))))).).)......))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(....{.....(((.((((((((((.....<.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((........((((.....((((((.((((((((....((((((((()).)))))))))).)))))))))))..))))))....)).[..(((((......].)))))....(((((.((((....((((((.((((((.(((((.(..(((((..(((((((.((.((((((.......[...((((....................].))))..))))))..)).)))))))...((((...)))).....)))))..)..))))).(((((((..((((.(...).)))))))))))....))))).).)))))).......}.....((((((...((.......))...)))))).....[[......(.((((((..(.(((((((......))))))..).).(((.....]]..))).....)))))..).)(((((((....))).))))...)))).)))))....(((((((..(((..(.(((((......(....).....))))).)(((((...((((....((((((((((....)))))..)))))...))))..))))).((((...((((.....>.......))))...))))..)))....)))))))...(((((.((.....(.((.......(((....)))....))).......((((.....(((.(((((.......))))).)))....))))..............)).)))))...(((((((..(.......)..))..(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....))))..))))))..))))). Cryo-EM structure of a Chaetomium thermophilum pre-60S ribosomal subunit - State Dbp10-1; RNA (3341-MER) 8i9t C2 158 3.6 RF00002 URS0002681402_759272 37129998 0003735 0005840 759272 aaacuuucaacaacggaucucuugguucuggcaucgaugaagaacgcagcgaaaugcgauaaguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgcccgccgguauuccggcgggcaugccuguucgagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<(.....>>............).>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((...(.]].)..........).)))..)...)))....((.....))(((((((((....)))))))))..................... Cryo-EM structure of a Chaetomium thermophilum pre-60S ribosomal subunit - State Dbp10-1; RNA (256-MER) 8i9v C1 2152 3.1 RF02543 URS00026813FF_759272 37129998 0003735 0005840 759272 uugaccucggaucagguaggaggacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaacagggauugcccuaguaacggcgagugaagcggcaacagcucaaauuugaaagcuggcuucggcccgcguuguaauuuggagaggaugcuuugggcgaggcuccuucugaguucccuggaacgggacgccacagagggugagagccccguauaguuggaagccaagccuguguaaagcuccuucgacgagucgaguaguuugggaaugcugcucaaaaugggagguaaauuucuucuaaagcuaaauaccggccagagaccgauagcgcacaaguagagugaucgaaagaugaaaagcacuuugaaaagaggguuaaauagcacgugaaauuguugaaagggaagcgcuugugaccagacuugcgcccggcggaucauccgguguucucaccggugcacuccgccgggcucaggccagcaucgguucuggcggggggauaaaggcccagggaauguggcuccuccgggaguguuauagcccuggguguaauacccucgccgggaccgaggaccgcgcucugcaaggaugcuggcguaauggucaccagcgacccgucuugaaacacggaccaaggagucaagguuuugcgcgaguguuuggguguaaaacccgcacgcguaaugaaagugaacguaggugagagcuucggcgcaucaucgaccgauccugauguauucggauggauuugaguaggagcguuaagccuuggacccgaaagauggugaacaaccaucuaguagcugguuaccgccgaaguuucccucaggauagcagugucgaccuucaguuuuaugagguaaagcgaaugaacuuuaaauauguaagaagcccuuguuacuuaacugaacgugggcauucgaauguaucgacacuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacgcgggguuaaggugccggaguggacgcucaucagacaccacaaaaggcguuaguacaucuugacagcaggacgguggccauggaagucggaauccgcuaaggacuguguaacaacucaccugccgaauguacuagcccugaaaauggauggcgcucaagcgucccacccauaccccgcccucaggguagaaacgaugcccugaggaguaggcggccguggaggucagugacgaagccuagggcgugagcccgggucgaacggccucuagugcagaucuuggugguaguagcaaauuugauagaacaauguagauaagggaagucggcuccguaacuugguacggacaggggaaucugcgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcaaaaucagcggggaagacccuguugagcuugacucuaguuugacauugugaaaagacauaggagguguagaauaggugggagcuucggcgccagugaaauaccacuacuccuauuguuuuuuuacuuauucaauugaagacauugucagguggggaguuccuuuagucccucgaaauuugaggcuagaggagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuuggaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacguggaccgucgugagacagguuagucccuacugaugaacucgucgcaaugguaauucagcuuaguacgagaggaaccgcugauucagauaauugguuuuugcgguuguccgaccgggcagugccgcgaagcuaccaucugcuggauaauggcugaacgccucuaagucagaauccaugccagaacgcgacgauaacccgcacguagacguauaagaauaggcuccggccucguauccuagcaggcgauuccuccgccggccucgaaguggccgucgguaauucgcguauugcaaagacacgcgcgggaucaaauccuuugcagacgacuuagaugugcgaaaggguccuguaagcaguagaguagccuuguuguuacgaucugcugaggguaagcccuccuucgccuagauuuc ........................<<<<<<.....<......>......>>>>>.>...<.....<<....>>..<<<<<......<<.....>>.....>>>>>..<<<..<<.......<<.<<<....>>>.>>.......>>....<<<<<.<<<<<<<<<..<<<<<<..<<....<<<<......>>>>.((......<<<.....))>>>....>>..>>>.>>>..>>>>....>>>>>>>>.>>........<<<<<<<........>>>>>>>.....<<<<<<......>>>>>>..>>>....>.............................<<....>>...............<<<<....>>>>..................................<<<<.<<<<<<<....<<.<<<<<<<<<<.<<.<<<<<<....>>>>>>>>...>>>>>>>>>>.>>.<<<<<<<.<<<<<<<<<<<<<<<.......<<<<<<<<......<<<<<....>>>>>.......>>>>>>>>......>>>>>>>>>>>>>>>........<<...>>.....>>>>>>>....>>>>>>>.>>>>..<<<<.<....>.>>>><<<<<<...<<<<<<<<<.<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<....>>...>>>>>.<<<<<<<<....<....>....>>>.>>>.>>....>>>>.>>>>>>>>>.<<.<..<<<<<<<.....>>>>>>...>..>.>>...<<<<<....<.<<<....>>>.><<<<<<<<<<....<<.<<<<<<<.....<<<........>>.>.....>>>>>....<<..<<<<.<......>>>>>.>>.......>>>>..>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>...>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<........<<<<.....<<<<<<.<<<<<<<<....<<<<<<.<..>.>>>>>>...<<<<<<<<<>>.>>>>>>>>>>.>>>>>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<.<<<.....<<<<<<.<<<<<<.<<<<<.<<<<<<<<..<<<<<<<<<<<<<<<<<..........<<<<<......................>>>>>.>>>>>>>.>>>>>>>>>>...<<<<..>>>>.....>>>>>>>>..>>>>>.<<<<<<<..<<<<<<...>>>>>>>>>>>>>....>>>>>.>.>>>>>>.............<<<<<<...<<.......>>...>>>>>>.....((........<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.....))..>>>.....>>>>>..>...<<<<<<....>>>.>>>.....>>>.>>>>>....<<<<<<<..<<<<.<.<<<<<.................>>>>>.><<<<<...<<<<....<<<<<<<<<<....>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>...<<<<<.<<.......<<.......<<<<..>>>>....>>........<<<<.....<<<.<<<<<.......>>>>>.>>>....>>>>..............>>.>>>>>...<<<<<<<.............>>....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>..>>>>>...>>>>>. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.(((....))).))....)........(((((.(((((((((..((((((..((..({((((......)))))[[(...).(((....}]])))....))..))).)))..))))....)))))))).))...)....(((((((........))))))).....(((((........)))))..)))..................................((....))............(..((((....))))............).....................((((.(((((((.....(.((((((((((.((.((((((....))))))))...)))))))))).)..(((((((((((((((((((((((.......((((((((......((((......)))).......))))))))......)))))))))))))))........((...))....))))))))....))))))).))))..((((........))))((((((..(.((((((((.((((..(((...(((.......)))...)))...((....)).......(((((..((....))...))))).((((((((....(....)....))).))).))....)))).))))))))..((.(...((((((.....))))))......).)))..(((((....(.(((....))).)((((((((((....((.(((((((.....(((........)).).....)))))....(((.((((.(......))))).)))......))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(....{.....(((.((((((((((.....<.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((........((((.....((((((.((((((((....((((((.(..).))))))...((((((((()).)))))))))).)))))))))))..))))))....)).[..(((((......].)))))....(((((.((((....((((((.((.(((.(((((.((((((((..(((((((.(((((((((.......[...((((..(......)..........].))))..))))))).)).)))))))...((((..)))).....))))))))..))))).(((((((..((((.(...).)))))))))))....))).).).)))))).......}.....((((((...((.......))...)))))).....[[......(.((((((..(.(((((((......))))))..).).(((.....]]..))).....)))))..).)(((((((....))).))))...)))).)))))....(((((((..(((..(.(((((......(....).....))))).)(((((...((((....((((((((((....)))))..)))))...))))..))))).((((...((.(.....>.......).))...))))..)))....)))))))...(((((.((.....(.((.......(((....)))....))).......((((.....(((.(((((.......))))).)))....))))..............)).)))))...(((((((..(.......)..))..(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....))))..))))))..))))). Cryo-EM structure of a Chaetomium thermophilum pre-60S ribosomal subunit - State Dbp10-2; RNA (3341-MER) 8i9v C2 158 3.1 RF00002 URS0002681402_759272 37129998 0003735 0005840 759272 aaacuuucaacaacggaucucuugguucuggcaucgaugaagaacgcagcgaaaugcgauaaguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgcccgccgguauuccggcgggcaugccuguucgagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((...(.]].)..........).)))..)...)))....((.....))(((((((((....)))))))))..................... Cryo-EM structure of a Chaetomium thermophilum pre-60S ribosomal subunit - State Dbp10-2; RNA (256-MER) 8i9w C1 2163 3.1 RF02543 URS00026813FF_759272 37129998 0003735 0005840 759272 uugaccucggaucagguaggaggacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaacagggauugcccuaguaacggcgagugaagcggcaacagcucaaauuugaaagcuggcuucggcccgcguuguaauuuggagaggaugcuuugggcgaggcuccuucugaguucccuggaacgggacgccacagagggugagagccccguauaguuggaagccaagccuguguaaagcuccuucgacgagucgaguaguuugggaaugcugcucaaaaugggagguaaauuucuucuaaagcuaaauaccggccagagaccgauagcgcacaaguagagugaucgaaagaugaaaagcacuuugaaaagaggguuaaauagcacgugaaauuguugaaagggaagcgcuugugaccagacuugcgcccggcggaucauccgguguucucaccggugcacuccgccgggcucaggccagcaucgguucuggcggggggauaaaggcccagggaauguggcuccuccgggaguguuauagcccuggguguaauacccucgccgggaccgaggaccgcgcucugcaaggaugcuggcguaauggucaccagcgacccgucuugaaacacggaccaaggagucaagguuuugcgcgaguguuuggguguaaaacccgcacgcguaaggugagagcuucggcgcaucaucgaccgauccugauguauucggauggauuugaguaggagcguuaagccuuggacccgaaagauggugaacuauaugggggcgaaagacuaaccaucuaguagcugguuaccgccgaaguuucccucaggauagcagugucgaccuucaguuuuaugagguaaagcgaaugaacuuuaaauauguaagaagcccuuguuacuuaacugaacgugggcauucgaauguaucgacacuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacgcgggguuaaggugccggaguggacgcucaucagacaccacaaaaggcguuaguacaucuugacagcaggacgguggccauggaagucggaauccgcuaaggacuguguaacaacucaccugccgaauguacuagcccugaaaauggauggcgcucaagcgucccacccauaccccgcccucaggguagaaacgaugcccugaggaguaggcggccguggaggucagugacgaagccuagggcgugagcccgggucgaacggccucuagugcagaucuuggugguaguagcauagaacaauguagauaagggaagucggcuccguaacuugguacggacaggggaaucugcgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcaaaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaaaagacauaggagguguagaauaggugggagcuucggcgccagugaaauaccacuacuccuauuguuuuuuuacuuauucaaugugaagacauugucagguggggaguuccuuuagucccucgaaauuugaggcuagaggagaaaaguuaccacagggauaacuggcuuguggcggccaagcguagcgacgucgcuuuuuggaugcggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggaccgucgugagacagguuagucccuacugaugaacucgucgcaaugguaauucagcuuaguacgagaggaaccgcugauucagauaauugguuuuugcgguuguccgaccgggcagugccgcgaagcuaccaucugcuggauaauggcugaacgccucuaagucagaauccaugccagaacgcgacgauacuacccgcacguuguagacguauaagaauaggcuccggccucguauccuagcaggcgauuccuccgccggccucgaaguggccgucgguaauucgcguauugcaauuuagacacgcgcgggaucaaauccuuugcagacgacuuagaugugcgaaaggguccuguaagcaguagaguagccuuguuguuacgaucugcugaggguaagcccuccuucgccuagauuuc ........................<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..<<<..<<.......<<.<<<....>>>.>>.......>>....<<<<<.<<<<<<<<<..<<<<<<..<<....<<<<......>>>>.((......<<<.....))>>>....>>..>>>.>>>..>>>>....>>>>>>>>.>>........<<<<<<<........>>>>>>>.....<<<<<<......>>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<.<<<<<<.<...<<.<<<<<<<<<.....<<<<<<....>>>>>>......>>>>>>>>>.>>.<<<<<<<.<<<<<<<<<<<<<<<.....<.<<<<<<<<......<<<<<....>>>>>.......>>>>>>>>....>.>>>>>>>>>>>>>>>........<<...>>.....>>>>>>>....>>>>>>>.>>>>..<<<<.<....>.>>>><<<<<<....<<<<<<<<.<<<<..<<<..<<<<<.....>>>>>..>>>....<<<<<..<<....>>...>>>>>.<<<<<<<<....<....>....>>>.>>>.>>....>>>>.>>>>>>>>..<<.<...<<<<<<...<.<<>>>.<<.<....>.>>.>>>>>>......>.>>...<<<<<....<.<<<....>>>.><<<<<<<<<<....<<.<<<<<<<.....<<<........>>.>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>..>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<.(......<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>...........)..>>...>>>>>>.>>>...>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.<<<<.....<<<<<<.<<<<<<<<....<<<<<<.<..>.>>>>>>...<<<<<<<<<>>.>>>>>>>>>>.>>>>>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<........<<<<<<.<<<<<<.<<<<<.<<<<<<<<..<<<<<<<<<<<<<<<<<..........<<<<<..<<....>>............>>>>>.>>>>>>>.>>>>>>>>>>...<<<<...>>>>.....>>>>>>>>..>>>>>.<<<<<<<..<<<<<<...>>>>>>>>>>>>>....>>>>>.>.>>>>>>.............<<<<<<...<<...>>...>>>>>>.....((...<<<<<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.....))..>>>.....>>>>>....>>>>>.<<<<<<<....>>>.>>>>....>>>.>>>>>....<<<<<<<..<<<<.<.<<<<<.................>>>>>.><<<<<...<<<<....<<<<<<<<<<....>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>.....<<<<<.<<.<<<......<<.......<<<<..>>>>....>>........<<<<.....<<<.<<<<<.......>>>>>.>>>....>>>>..............>>>>>.>>>>>...<<<<<<<.............>>....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>..>>>>>...>>>>>. ........................(((((......(......).......)))).).........((....))...((((......((.....)).....))))...((((.........(((.(((....))).))....)........(((((.(((((((((..((((((..((..({((((......)))))[[(...).(((....}]])))....))..))).)))..))))....)))))))).))...)....(((((((........))))))).....(((((........)))))..)))..................................((....))............(..((((....))))............).....................((((.(((((((....((.((((((((((....((((((....)))))).....)))))))))).)).(((((((((((((((((((((((.......((((((((.......(((......)))........))))))))......)))))))))))))))........((...))....))))))))....))))))).))))..((((........))))((((((..(.((((((((.((((..(((...((((.....))))...)))....(((((..((....))...))))).((((((((....(....)....))).))).))....)))).))))))))..((.(...((((((...(.(()))..(.(....).)..))))))......).)))..(((((....(.(((....))).)((((((((((....((.(((((((.....(((........)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([.[...(.((((((......(....{.....(((.((((((((((.....<.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........].].)....))))))))))...)))))))(((((((((.........)))))))))....))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.((((.....((((((.((((((((....((((((.(..).))))))...(((((((.()..)))))))))).)))))))))))..))))))....)).[..(((((......].)))))....(((((..(((...[....((((((.((((((.(((((.((((((((..(((((((.(((((((((.......[...((((..((....))..........].))))..))))))).)).)))))))...((((...)))).....))))))))..))))).(((((((..((((.(...).)))))))))))....))))).).)))))).......}.....((((((...((...))...)))))).....[[..(((((((((((..(.(((((((......))))))..).).(((.....]]..))).....))))).]..))))))(((((((....))).))))....))).)))))....(((((((..(((..(.(((((......(....).....))))).)(((((...((((....((((((((((....)))))..)))))...))))..))))).((((...((((.....>.......))))...))))..)))....))))))).....(((((.((.(((....(.((.......(((....)))....))).......((((.....(((.(((((.......))))).)))....))))..............))))).)))))...(((((((..(.......)..))..(.(((((((((.(((....((((.(..(((..(.....).)))..)))))...)))....))))..))))))..))))). Cryo-EM structure of a Chaetomium thermophilum pre-60S ribosomal subunit - Dbp10-3; RNA (3341-MER) 8i9w C2 256 3.1 RF00002 URS0002681404_759272 37129998 0003735 0005840 759272 aaacuuucaacaacggaucucuugguucuggcaucgaugaagaacgcagcgaaaugcgauaaguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgcccgccgguauuccggcgggcaugccuguucgagcgucauuucaaccaucaagcccugggcuuguguuggggacccgcggcugcucgcgggcccugaaaagcaguggcgggcucgcuggcgggugccagccguaaaaccc .........................................<<<<<<<((....>>>>.....<.<<<<.....))............>.>>>..>...>>>....<<.....>><<<<<<<<<....>>>>>>>>>............................<<<<<<...>>>>>>....<<<<.<<<<<<<....>>>>>>>>>>>..........<<<<<<<<<<<..>>>>>>.>>.>>>......... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))............................((((((...))))))...(((((.((((((......))))))))))..).......(((((((((((())))))).)).)))......... Cryo-EM structure of a Chaetomium thermophilum pre-60S ribosomal subunit - Dbp10-3; RNA (319-MER) 8i9x C1 2658 2.8 RF02543 URS00026813FF_759272 37129998 0003735 0005840 759272 uugaccucggaucagguaggaggacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaacagggauugcccuaguaacggcgagugaagcggcaacagcucaaauuugaaagcuggcuucggcccgcguuguaauuuggagaggaugcuuugggcgaggcuccuucugaguucccuggaacgggacgccacagagggugagagccccguauaguuggaagccaagccuguguaaagcuccuucgacgagucgaguaguuugggaaugcugcucaaaaugggagguaaauuucuucuaaagcuaaauaccggccagagaccgauagcgcacaaguagagugaucgaaagaugaaaagcacuuugaaaagaggguuaaauagcacgugaaauuguugaaagggaagcgcuugugaccagacuugcgcccggcggaucauccgguguucucaccggugcacuccgccgggcucaggccagcaucgguucuggcggggggauaaaggcccagggaauguggcuccuccgggaguguuauagcccuggguguaauacccucgccgggaccgaggaccgcgcucugcaaggaugcuggcguaauggucaccagcgacccgucuugaaacacggaccaaggagucaagguuuugcgcgaguguuuggguguaaaacccgcacgcguaaggugagagcuucggcgcaucaucgaccgauccugauguauucggauggauuugaguaggagcguuaagccuuggacccgaaagauggugaacuaugcuuggauagggugaagccagaggaaacucugguggaggcucgcugacgugcaagaucgucaaaucugagcaugggggcgaaagacuaaccaucuaguagcugguuaccgccgaaguuucccucaggauagcagugucgaccuucaguuuuaugagguaaagcgaaugaacuuuaaauauguaagaagcccuuguuacuuaacugaacgugggcauucgaauguaucgacacuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacgcgggguuaaggugccggaguggacgcucaucagacaccacaaaaggcguuaguacaucuugacagcaggacgguggccauggaagucggaauccgcuaaggacuguguaacaacucaccugccgaauguacuagcccugaaaauggauggcgcucaagcgucccacccauaccccgcccucaggguagaaacgaugcccugaggaguaggcggccguggaggucagugacgaagccuagggcgugagcccgggucgaacggccucuagugcagaucuuggugguaguagcaaauacuucaaugagaacuugaaggaccgaaguggggaaagguuccaugugaacagcgguuggacauggguuagucgauccuaagccauagggaaguuccguuucaaaggggcacucgugccccguguggcgaaagggaagccgguuaauauuccggcaccuggauguggguuuugcgcggcaacgcaacugaacgcggagacgacggcgggggccccgggcagaguucucuuuucuucuuaacggucuaucacccuggaaacaguuugucuggagauaggguuuaauggccggaagagcccgacacuucugucggguccggugcgcucucgacgucccuugaaaauccgcgggagggaauaauucucacgccaggucguacucauaaccgcagcagguccccaaggugaacagccucugguugauagaacaauguagauaagggaagucggcuccguaacuugguacggacaggggaaucugcgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcaaaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaaaagacauaggagguguagaauaggugggagcuucggcgccagugaaauaccacuacuccuauuguuuuuuuacuuauucaaugugaagacauugucagguggggaguuccuuuagucccucgaaauuugaggcuagaggagaaaaguuaccacagggauaacuggcuuguggcggccaagcguagcgacgucgcuuuuuggaugcggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggaccgucgugagacagguuagucccuacugaugaacucgucgcaaugguaauucagcuuaguacgagaggaaccgcugauucagauaauugguuuuugcgguuguccgaccgggcagugccgcgaagcuaccaucugcuggauaauggcugaacgccucuaagucagaauccaugccagaacgcgacgauacuacccgcacguuguagacguauaagaauaggcuccggccucguauccuagcaggcgauuccuccgccggccucgaaguggccgucgguaauucgcguauugcaauuuagacacgcgcgggaucaaauccuuugcagacgacuuagaugugcgaaaggguccuguaagcaguagaguagccuuguuguuacgaucugcugaggguaagcccuccuucgccuagauuuc ........................<<<<<<.....<<....>>......>>>>>.>...<.....<<....>>..<<<<<......<<.....>>.....>>>>>..<<<..<<.......<<.<<<....>>>.>>.......>>....<<<<<.<<<<<<<<<..<<<<<<..<<....<<<<......>>>>.((......<<<.....))>>>....>>..>>>.>>>..>>>>....>>>>>>>>.>>........<<<<<<<........>>>>>>>.....<<<<<<......>>>>>>..>>>....>.............................<<....>>...............<<<<....>>>>..................................<<<<.<<<<<<.<...<<.<<<<<<<<<.....<<<<<<....>>>>>>......>>>>>>>>>.>>.<<<<<<<.<<<<<<<<<<<<<<<.......<<<<<<<<......<<<<<....>>>>>.......>>>>>>>>......>>>>>>>>>>>>>>>........<<...>>.....>>>>>>>....>>>>>>>.>>>>..<<<<.<....>.>>>><<<<<<...<<<<<<<<<.<<<<..<<<..<<<<<.....>>>>>..>>>....<<<<<..<<....>>...>>>>>.<<<<<<<<....<....>....>>>.>>>.>>....>>>>.>>>>>>>>>.<<.<..<<<<<<<...<.<<<<<<<<<..<<<<...<<<<<<<....>>>>>>>...>.>>>..<<<<<........>>>>>..>>>>>>>>>>.<<.<....>.>>.>>>>>>>.....>.>>...<<<<<....<.<<<....>>>.><<<<<<<<<<....<<.<<<<<<<.....<<<........>>.>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>..>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<((......<<<<<<......<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>...........)).>....>>>>>>.>>>...>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<...<<<....>>>........<<<<<......>>>>>....>>>....>>...<<<<<........>>>>>))<<<<.<<<<.<<<....<<<....>>>.......<<<<<<...<<<<.<<<<<<<<<<<<<.<<<<...((..>>>>.><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<<....>>>>>>>>>>>>.>.>>>>>>>.>>>>.........>>>>>>.........>>>...>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<.<<<<<<<<....<<<<<<.<..>.>>>>>>...<<<<<<<<<>>.>>>>>>>>>>.>>>>>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<........<<<<<<.<<<<<<.<<<<<.<<<<<<<<..<<<<<<<<<<<<<<<<<..........<<<<<..<<....>>............>>>>>.>>>>>>>.>>>>>>>>>>...<<<<...>>>>.....>>>>>>>>..>>>>>.<<<<<<<..<<<<<<...>>>>>>>>>>>>>....>>>>>.>.>>>>>>.............<<<<<<...<<...>>...>>>>>>.....((...<<<<<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.....))..>>>.....>>>>>....>>>>>.<<<<<<<....>>>.>>>>....>>>.>>>>>....<<<<<<<..<<<<.<.<<<<<.................>>>>>.><<<<<...<<<<....<<<<<<<<<<))..>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>.....<<<<<.<<.<<<......<<.......<<<<..>>>>....>>........<<<<.....<<<.<<<<<.......>>>>>.>>>....>>>>..............>>>>>.>>>>>...<<<<<<<.............>>....<<<<<<<<<.<<<....<<<<.<..<<<<<......>>>>>..>>>>>...>>>....>>>>..>>>>>...>>>>>. ........................(((((......(......).......)))).).........((....))...((((......((.....)).....))))...((((.........(((.(((....))).))....)........(((((.(((((((((..((((((..((..({((((......)))))[[(...).(((....}]])))....))..)).))))..))))....)))))))).))...)....(((((((........))))))).....(((((........)))))..)))..................................((....))............(..((((....))))............).....................((((.(((((((....((.(((((((((.....((((((....))))))......))))))))).)).(((((((((((((((((((((((.......((((((((......(((((....))))).......))))))))......)))))))))))))))........((...))....))))))))....))))))).))))..((((........))))((((((..(.((((((((.((((..(((...((((.....))))...)))....(((((..((....))...))))).((((((((....(....)....))).))).))....)))).))))))))..((.(...((((((...(.(((((((((..(.((...(((((((....)))))))...).).)..(((((........)))))..))))))))))..(.(....).)..))))))......).)))..(((((....(.(((....))).)((((((((((....((.(((((((.....(((........)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([.[...(.((((((......(....{.....(((.((((((((((.....<.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........].].)....))))))))))...)))))))(((((((((.........)))))))))....))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((..(((((((...((.....)).))))))....[[(((.((...(((...(((....)))........(((((......)))))....)))....))...(((((........)))))]]((((.((((((((...((((....)))...(...((((((...((((.(((((((((((((.((((...[[..)))).)(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....))).).)))))))).))).))).....((......)).)))).((((.....))))..))))..((((.....((((((.((((((((....((((((.(..).))))))...(((((((.()..)))))))))).)))))))))))..))))))....)).[..(((((......].)))))....(((((..(((...[....((((((.((((((.(((((.((((((((..(((((((.(((((((((.......[...((((..((....))..........].))))..))))))).)).)))))))...((((...)))).....))))))))..))))).(((((((..((((.(...).)))))))))))....))))).).)))))).......}.....((((((...((...))...)))))).....[[..(((((((((((..(.(((((((......))))))..).).(((.....]]..))).....))))).]..))))))(((((((....))).))))....))).)))))....(((((((..(((..(.(((((......(....).....))))).)(((((...((((....((((((((((]]..)))))..)))))...))))..))))).((((...((((.....>.......))))...))))..)))....))))))).....(((((.((.(((....(.((.......(((....)))....))).......((((.....(((.(((((.......))))).)))....))))..............))))).)))))...(((((((..(.......)..))..(.(((((((((.(((....((((.(..(((..(.....).)))..)))))...)))....))))..))))))..))))). Cryo-EM structure of a Chaetomium thermophilum pre-60S ribosomal subunit - Ytm1-1; RNA (3341-MER) 8i9x C2 256 2.8 RF00002 URS0002681404_759272 37129998 0003735 0005840 759272 aaacuuucaacaacggaucucuugguucuggcaucgaugaagaacgcagcgaaaugcgauaaguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgcccgccgguauuccggcgggcaugccuguucgagcgucauuucaaccaucaagcccugggcuuguguuggggacccgcggcugcucgcgggcccugaaaagcaguggcgggcucgcuggcgggugccagccguaaaaccc .........................................<<<<<<<<<....>>>>.....<.<<<......>>..............>>>..>...>>>....<<.....>><<<<<<<<<....>>>>>>>>>............................<<<<<<...>>>>>>....<<<<.<<<<<<<....>>>>>>>>>>>.........<<<<<<<<<<<<..>>>>>>.>>.>>>>........ .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))............................((((((...))))))...(((((.((((((......))))))))))..).......(((((((((((())))))).)).)))......... Cryo-EM structure of a Chaetomium thermophilum pre-60S ribosomal subunit - Ytm1-1; RNA (319-MER) 8i9y C1 2609 3.1 RF02543 URS00026813FF_759272 37129998 0003735 0005840 759272 uugaccucggaucagguaggaggacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaacagggauugcccuaguaacggcgagugaagcggcaacagcucaaauuugaaagcuggcuucggcccgcguuguaauuuggagaggaugcuuugggcgaggcuccuucugaguucccuggaacgggacgccacagagggugagagccccguauaguuggaagccaagccuguguaaagcuccuucgacgagucgaguaguuugggaaugcugcucaaaaugggagguaaauuucuucuaaagcuaaauaccggccagagaccgauagcgcacaaguagagugaucgaaagaugaaaagcacuuugaaaagaggguuaaauagcacgugaaauuguugaaagggaagcgcuugugaccagacuugcgcccggcggaucauccgguguucucaccggugcacuccgccgggcucaggccagcaucgguucuggcggggggauaaaggcccagggaauguggcuccuccgggaguguuauagcccuggguguaauacccucgccgggaccgaggaccgcgcucugcaaggaugcuggcguaauggucaccagcgacccgucuugaaacacggaccaaggagucaagguuuugcgcgaguguuuggguguaaaacccgcacgcguaaggugagagcuucggcgcaucaucgaccgauccugauguauucggauggauuugaguaggagcguuaagccuuggacccgaaagauggugaacuaugcuuggauagggugaagccagaggaaacucugguggaggcucgcugacgugcaagaucgucaaaucugagcaugggggcgaaagacuaaccaucuaguagcugguuaccgccgaaguuucccucaggauagcagugucgaccuucaguuuuaugagguaaagcgaaugaacuuuaaauauguaagaagcccuuguuacuuaacugaacgugggcauucgaauguaucgacacuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacgcgggguuaaggugccggaguggacgcucaucagacaccacaaaaggcguuaguacaucuugacagcaggacgguggccauggaagucggaauccgcuaaggacuguguaacaacucaccugccgaauguacuagcccugaaaauggauggcgcucaagcgucccacccauaccccgcccucaggguagaaacgaugcccugaggaguaggcggccguggaggucagugacgaagccuagggcgugagcccgggucgaacggccucuagugcagaucuuggugguaguagcaaauacuucaaugagaacuugaaggaccgaaguggggaaagguuccaugugaacagcgguuggacauggguuagucgauccuaagccauagggaaguuccguuucaaaggggcacucgugccccguguggcgaaagggaagccgguuaauauuccggcaccuggauguggguuuugcgcggcaacgcaacugaacgcggagacgacggcgggggccccgggcagaguucucuuuucuucuuaacggucuaucacccuggaaacaguuugucuggagauaggguuuaauggccggaagagcccgacacuucugucggguccggugcgcucucgacgucccuugaaaauccgcgggagggaauaauucucacgccaggucguacucauaaccgcagcagguccccaaggugaacagccucugguugauagaacaauguagauaagggcugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcaaaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaaaagacauaggagguguagaauaggugggagcuucggcgccagugaaauaccacuacuccuauuguuuuuuuacuuauucaaugugaagacauugucagguggggaguuccuuuagucccucgaaauuugaggcuagaggagaaaaguuaccacagggauaacuggcuuguggcggccaagcguagcgacgucgcuuuuuggaugcggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggaccgucgugagacagguuagucccuacugaugaacucgucgcaaugguaauucagcuuaguacgagaggaaccgcugauucagauaauugguuuuugcgguuguccgaccgggcagugccgcgaagcuaccaucugcuggauaauggcugaacgccucuaagucagaauccaugccagaacgcgacgauacuacccgcacguuguagacguauaagaauaggcuccggccucguauccuagcaggcgauuccuccgccggccucgaaguggccgucgguaauucgcguauugcaauuuagacacgcgcgggaucaaauccuuugcagacgacuuagaugugcgaaaggguccuguaagcaguagaguagccuuguuguuacgaucugcugaggguaagcccuccuucgccuagauuuc ........................<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..<<<..<<.......<<.<<<....>>>.>>.......>>....<<<<<.<<<<<<<<<..<<<<<<..<<....<<<<......>>>>.((......<<<.....))>>>....>>..>>>.>>>..>>>>....>>>>>>>>.>>........<<<<<<<........>>>>>>>.....<<<<<<......>>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<.<<<<<<.<...<<.<<<<<<<<<.....<<<<<<....>>>>>>......>>>>>>>>>.>>.<<<<<<<.<<<<<<<<<<<<<<<.......<<<<<<<<......<<<<<....>>>>>.......>>>>>>>>......>>>>>>>>>>>>>>>........<<...>>.....>>>>>>>....>>>>>>>.>>>>..<<<<........>>>><<<<<<....<<<<<<<<.<<<<..<<<..<<<<<.....>>>>>..>>>....<<<<<..<<....>>...>>>>>.<<<<<<<<....<....>....>>>.>>>.>>....>>>>.>>>>>>>>..<<.<...<<<<<<...<.<<<<<<<<<..<<<<...<<<<<<<....>>>>>>>...>.>>>..<<<<<........>>>>>..>>>>>>>>>>.<<.<....>.>>.>>>>>>......>.>>...<<<<<....<.<<<....>>>.><<<<<<<<<<....<<.<<<<<<<.....<<<........>>.>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>..>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<((......<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>...........)).>>...>>>>>>.>>>...>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<...<<<....>>>........<<<<<......>>>>>....>>>....>>...<<<<<........>>>>>))<<<<.<<<<.<<<....<<<....>>>.......<<<<<<...<<<<.<<<<<<<<<<<<<.<<<<...((..>>>>.><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<<....>>>>>>>>>>>>.>.>>>>>>>.>>>>.........>>>>>>.........>>>...>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<.<<<......>>>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<........<<<<<<.<<<<<<.<<<<<.<<<<<<<<..<<<<<<<<<<<<<<<<<..........<<<<<..<<....>>............>>>>>.>>>>>>>.>>>>>>>>>>...<<<<...>>>>.....>>>>>>>>..>>>>>.<<<<<<<..<<<<<<...>>>>>>>>>>>>>....>>>>>.>.>>>>>>.............<<<<<<...<<...>>...>>>>>>.....((...<<<<<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.....))..>>>.....>>>>>....>>>>>.<<<<<<<....>>>.>>>>....>>>.>>>>>....<<<<<<<..<<<<.<.<<<<<.................>>>>>.><<<<<...<<<<....<<<<<<<<<<))..>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>.....<<<<<.<<.<<<......<<.......<<<....>>>....>>........<<<<.....<<<.<<<<<.......>>>>>.>>>....>>>>..............>>>>>.>>>>>...<<<<<<<.............>>....<<<<<<<<<.<<<....<<<<.<..<<<<<......>>>>>..>>>>>...>>>....>>>>..>>>>>...>>>>>. ........................(((((......(......).......)))).).........((....))...((((......((.....)).....))))...((((.........(((.(((....))).))....)........(((((.(((((((((..((((((..((..({((((......)))))[[(...).(((....}]])))....))..))).)))..))))....)))))))).))...)....(((((((........))))))).....(((((........)))))..)))..................................((....))............(..((((....))))............).....................((((.(((((((....((.((((((((((....((((((....)))))).....)))))))))).)).(((((((((((((((((((((((.......((((((((....(.(((((....)))))...)...))))))))......)))))))))))))))........((...))....))))))))....))))))).))))..((((........))))((((((..(.((((((((.((((..(((...((((.....))))...)))....(((((..((....))...))))).((((((((....(....)....))).))).))....)))).))))))))..((.(...((((((...(.(((((.(((..((((...(((((((....)))))))...).)))..(((((........)))))..))).))))))..(.(....).)..))))))......).)))..(((((....(.(((....))).)(((((((((.....((.((((((......(((........)).)......))))...((((.((((.(......))))).)))).....))))...))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([.[...(.((((((......(....{.....(((.((((((((((.....<.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........].].)....))))))))))...)))))))(((((((((.........)))))))))....))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((..(((((((...((.....)).))))))....[[(((.((...(((...(((....)))........(((((......)))))....)))....))...(((((........)))))]]((((.((((((((...((((....)))...(...((((((...((((.(((((((((((((.((((...[[..)))).)(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....))).).)))))))).))).))).....((......)).)))).((((.....))))..))))..((((.....((((((.((((....))))))))))..))))))....)).[..(((((......].)))))....(((((..(((...[....((((((.((((((.(((((.((((((((..(((((((.(((((((((.......[...((((..((....))..........].))))..))))))).)).)))))))...((((...)))).....))))))))..))))).(((((((..((((((...)))))))))))))....))))).).)))))).......}.....((((((...((...))...)))))).....[[..(((((((((((..(.(((((((......))))))..).).(((.....]]..))).....))))).]..))))))(((((((....))).))))....))).)))))....(((((((..(((..(.(((((......(....).....))))).)(((((...((((....((((((((((]]..)))))..)))))...))))..))))).((((...((((.....>.......))))...))))..)))....))))))).....(((((.((.(((....(.((.......(((....)))....))).......((((.....(((.(((((.......))))).)))....))))..............))))).)))))...(((((((..(.......)..))..(.(((((((((.(((....((((.(..(((..(.....).)))..)))))...)))....))))..))))))..))))). Cryo-EM structure of a Chaetomium thermophilum pre-60S ribosomal subunit - Ytm1-2; RNA (3341-MER) 8i9y C2 256 3.1 RF00002 URS0002681404_759272 37129998 0003735 0005840 759272 aaacuuucaacaacggaucucuugguucuggcaucgaugaagaacgcagcgaaaugcgauaaguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgcccgccgguauuccggcgggcaugccuguucgagcgucauuucaaccaucaagcccugggcuuguguuggggacccgcggcugcucgcgggcccugaaaagcaguggcgggcucgcuggcgggugccagccguaaaaccc .........................................<<<<<<<((....>>>>.....<.<<<<.....))............>.>>>..>...>>>....<<.....>><<<<<<<<<....>>>>>>>>>............................<<<<<<...>>>>>>....<<<<.<<<<<<<....>>>>>>>>>>>.........<<<<<<<<<<<<..>>>>>>.>>.>>>>........ .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))............................((((((...))))))...(((((.(((((((....)))))))))))..).......(((((((((((())))))).)).)))......... Cryo-EM structure of a Chaetomium thermophilum pre-60S ribosomal subunit - Ytm1-2; RNA (319-MER) 8i9z C1 2787 2.7 RF02543 URS00026813FF_759272 37129998 0003735 0005840 759272 uugaccucggaucagguaggaggacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaacagggauugcccuaguaacggcgagugaagcggcaacagcucaaauuugaaagcuggcuucggcccgcguuguaauuuggagaggaugcuuugggcgaggcuccuucugaguucccuggaacgggacgccacagagggugagagccccguauaguuggaagccaagccuguguaaagcuccuucgacgagucgaguaguuugggaaugcugcucaaaaugggagguaaauuucuucuaaagcuaaauaccggccagagaccgauagcgcacaaguagagugaucgaaagaugaaaagcacuuugaaaagaggguuaaauagcacgugaaauuguugaaagggaagcgcuugugaccagacuugcgcccggcggaucauccgguguucucaccggugcacuccgccgggcucaggccagcaucgguucuggcggggggauaaaggcccagggaauguggcuccuccgggaguguuauagcccuggguguaauacccucgccgggaccgaggaccgcgcucugcaaggaugcuggcguaauggucaccagcgacccgucuugaaacacggaccaaggagucaagguuuugcgcgaguguuuggguguaaaacccgcacgcguaaggugagagcuucggcgcaucaucgaccgauccugauguauucggauggauuugaguaggagcguuaagccuuggacccgaaagauggugaacuaugcuuggauagggugaagccagaggaaacucugguggaggcucgcugacgugcaagaucgucaaaucugagcaugggggcgaaagacuaaccaucuaguagcugguuaccgccgaaguuucccucaggauagcagugucgaccuucaguuuuaugagguaaagcgaaugaacuuuaaauauguaagaagcccuuguuacuuaacugaacgugggcauucgaauguaucgacacuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacgcgggguuaaggugccggaguggacgcucaucagacaccacaaaaggcguuaguacaucuugacagcaggacgguggccauggaagucggaauccgcuaaggacuguguaacaacucaccugccgaauguacuagcccugaaaauggauggcgcucaagcgucccacccauaccccgcccucaggguagaaacgaugcccugaggaguaggcggccguggaggucagugacgaagccuagggcgugagcccgggucgaacggccucuagugcagaucuuggugguaguagcaaauacuucaaugagaacuugaaggaccgaaguggggaaagguuccaugugaacagcgguuggacauggguuagucgauccuaagccauagggaaguuccguuucaaaggggcacucgugccccguguggcgaaagggaagccgguuaauauuccggcaccuggauguggguuuugcgcggcaacgcaacugaacgcggagacgacggcgggggccccgggcagaguucucuuuucuucuuaacggucuaucacccuggaaacaguuugucuggagauaggguuuaauggccggaagagcccgacacuucugucggguccggugcgcucucgacgucccuugaaaauccgcgggagggaauaauucucacgccaggucguacucauaaccgcagcagguccccaaggugaacagccucugguugauagaacaauguagauaagggaagucggcuccguaacuucgggaaaagggcucuaaggguugggcacguugggcuuugggcggacgcccugggagcagagggccucuagccgggcaaccggccggcggcccucagcacccgggguugaagcccuuagcccggcgugcgguuaacaaccaacuuagaacugguacggacacacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcaaaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaaaagacauaggagguguagaauaggugggagcuucggcgccagugaaauaccacuacuccuauuguuuuuuuacuuauucaaugugaagacauugucagguggggaguuccuuuagucccucgaaauuugaggcuagaggagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcugaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggagugagcuggaccgucgugagacagguuagucccuacugaugaacucgucgcaaugguaauucagcuuaguacgagaggaaccgcugauucagauaauugguuuuugcgguuguccgaccgggcagugccgcgaagcuaccaucugcuggauaauggcugaacgccucuaagucagaauccaugccagaacgcgacgauacuacccgcacguuguagacguauaagaauaggcuccggccucguauccuagcaggcgauuccuccgccggccucgaaguggccgucgguaauucgcguauugcaauuuagacacgcgcgggaucaaauccuuugcagacgacuuagaugugcgaaaggguccuguaagcaguagaguagccuuguuguuacgaucugcugaggguaagcccuccuucgccuagauuuc ........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..<<<..<<.......<<.<<<....>>>.>>.......>>....<<<<<.<<<<<<<<<..<<<<<<..<<....<<<<......>>>>.((......<<<.....))>>>....>>..>>>.>>>..>>>>....>>>>>>>>.>>........<<<<<<<........>>>>>>>.....<<<<<<......>>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<.<<<<<<.<...<<.<<<<<<<<<.....<<<<<<....>>>>>>......>>>>>>>>>.>>.<<<<<<<.<<<<<<<<<<<<<<<.......<<<<<<<<......<<<<<....>>>>>.......>>>>>>>>......>>>>>>>>>>>>>>>........<<...>>.....>>>>>>>....>>>>>>>.>>>>..<<<<.<....>.>>>><<<<<<....<<<<<<<<.<<<<..<<<...<<<<.....>>>>...>>>....<<<<<..<<....>>...>>>>>.<<<<<<<<....<....>....>>>.>>>.>>....>>>>.>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<<...<<<<<<<....>>>>>>>...>.>>>..<<<<<........>>>>>..>>>>>>>>>..<<.<....>.>>.>>>>>>>.....>.>>...<<<<<....<.<<<....>>>.><<<<<<<<<<....<<.<<<<<<<.....<<<........>>.>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>..>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<......<..........<<<.<<<<<<<<<<.....<.<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>.>.>>>>>>>>>>>>>..........))).>....>>>>>>.>>>...>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<...<<<....>>>........<<<<<......>>>>>....>>>....>>...<<<<<........>>>>>))<<<<.<<<<.<<<....<<<....>>>.......<<<<<<...<<<<.<<<<<<<<<<<<<.<<<<...((..>>>>.><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<<....>>>>>>>>>>>>.>.>>>>>>>.>>>>.........>>>>>>.........>>>...>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.......<.<<<<<<.<.<<.................<<<<<.<<<<<..<.<<<..<<<<....<<<<<<<<.<<.<<<<<<<.<<.<<<<<....>>>>>.>>.>>>>>>>.>>.>>>>>>>>....>>>>..>>>>...>>>>>......>>>>>......>>...>.>>>>>>....>...>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<........<<<<<<.<<<<<<.<<<<<.<<<<<<<<..<<<<<<<<<<<<<<<<<..........<<<<<......................>>>>>.>>>>>>>.>>>>>>>>>>...<<<<...>>>>.....>>>>>>>>..>>>>>..<<<<<<..<<<<<<...>>>>>>>>>>>>.....>>>>>.>.>>>>>>...((........<<<<<<...<<.......>>...>>>>>>((....<<<<.<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.<...))>.>>>.....>>>>>)).>>>>.<<<<<<<....>>>.>>>>....>>>.>>>>>....<<<<<<<..<<<<.<.<<<<<.................>>>>>.><<<<<...<<<<....<<<<<<<<<<))..>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>.....<<<<<.<<.<<<......<<.......<<<....>>>....>>........<<<<.....<<<.<<<<<.......>>>>>.>>>....>>>>..............>>>>>.>>>>>...<<<<<<<.............>>....<<<<<<<<<.<<<....<<<<.<..<<<<<......>>>>>..>>>>>...>>>....>>>>..>>>>>...>>>>>. ........................(((((......(......).......)))).).........((....))...((((......((.....)).....))))...((((.........(((.(((....))).))....)........(((((.(((((((((..((((((..((..({((((......)))))[[(...).(((....}]])))....))..))).)))..))))....)))))))).))...)....(((((((........))))))).....(((((........)))))..)))..................................((....))............(..((((....))))............).....................((((.((((((.....((.((((((((((....((((((....)))))).....)))))))))).)).(((((((((((((((((((((((.......((((((((.......(((......)))........))))))))......)))))))))))))))........((...))....)))))))).....)))))).))))..((((........))))((((((..(.((((((((.((((..(((...((((.....))))...)))....(((((..((....))...))))).((((((((....(....)....))).))).))....)))).))))))))..((.(...((((((...(.(((((((((..((((...(((((((....)))))))...).)))..(((((........)))))..)))))))))).((.(....).)).))))))......).)))..(((((....(.(((....))).)((((((((((....((.(((((((.....(((........)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(....{.....(((.((((((((((.....<.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((..(((((((...((.....)).))))))....[[(((.((...(((...(((....)))........(((((......)))))....)))....))...(((((........)))))]]((((..(((((((...((((....)))...(...((((((...((((.(((((((((((((.((((...[[..)))).)(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....))).).))).)))).))).))).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.((((((.(.((.................(((((.(((((..(..((..((((.....(((((((.((.(((((((.((.(((((....))))).)).))))))).)).))))))).....))))..)).)...)))))......)))))......))...).))))))....)..))).)))))))..))))))....)).[..(((((......].)))))....(((((..(((........((((((.((((((.(((((.((((((((..(((((((((((((((((.......[...((((..(......)..........].))))..))))))).))))))))))...((((...)))).....))))))))..))))).(((((((..((((((...)))))))))))))....))))).).))))))...[[..}.....((((((...((.......))...))))))[[...(((((.(((((..(.(((((((......))))))..).).(((.....]]..))).....)))))]].)))))(((((((....))).))))....))).)))))....(((((((..(((..(.(((((......(....).....))))).)(((((...((((....((((((((((]]..)))))..)))))...))))..))))).((((...((((.....>.......))))...))))..)))....))))))).....(((((.((.(((....(.((.......(((....)))....))).......((((.....(((.(((((.......))))).)))....))))..............))))).)))))...(((((((..(.......)..))..(.(((((((((.(((....((((([..((((.(.....)))))).]))))...)))....))))..))))))..))))). Cryo-EM structure of a Chaetomium thermophilum pre-60S ribosomal subunit - State Spb4; RNA (3341-MER) 8i9z C2 256 2.7 RF00002 URS0002681404_759272 37129998 0003735 0005840 759272 aaacuuucaacaacggaucucuugguucuggcaucgaugaagaacgcagcgaaaugcgauaaguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgcccgccgguauuccggcgggcaugccuguucgagcgucauuucaaccaucaagcccugggcuuguguuggggacccgcggcugcucgcgggcccugaaaagcaguggcgggcucgcuggcgggugccagccguaaaaccc .........................................<<<<<<<((....>>>>.....<.<<<<.....))............>.>>>..>...>>>....<<.....>><<<<<<<<<....>>>>>>>>>............................<<<<<<...>>>>>>....<<<<.<<<<<<<....>>>>>>>>>>>.........<<<<<<<<<<<<..>>>>>>.>>.>>>>........ .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))............................((((((...))))))...(((((.((((((......))))))))))..).......(((((((((((())))))).)).)))......... Cryo-EM structure of a Chaetomium thermophilum pre-60S ribosomal subunit - State Spb4; RNA (319-MER) 8ia0 C1 2928 2.7 RF02543 URS00026813FF_759272 37129998 0003735 0005840 759272 uugaccucggaucagguaggaggacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaacagggauugcccuaguaacggcgagugaagcggcaacagcucaaauuugaaagcuggcuucggcccgcguuguaauuuggagaggaugcuuugggcgaggcuccuucugaguucccuggaacgggacgccacagagggugagagccccguauaguuggaagccaagccuguguaaagcuccuucgacgagucgaguaguuugggaaugcugcucaaaaugggagguaaauuucuucuaaagcuaaauaccggccagagaccgauagcgcacaaguagagugaucgaaagaugaaaagcacuuugaaaagaggguuaaauagcacgugaaauuguugaaagggaagcgcuugugaccagacuugcgcccggcggaucauccgguguucucaccggugcacuccgccgggcucaggccagcaucgguucuggcggggggauaaaggcccagggaauguggcuccuccgggaguguuauagcccuggguguaauacccucgccgggaccgaggaccgcgcucugcaaggaugcuggcguaauggucaccagcgacccgucuugaaacacggaccaaggagucaagguuuugcgcgaguguuuggguguaaaacccgcacgcguaaggugagagcuucggcgcaucaucgaccgauccugauguauucggauggauuugaguaggagcguuaagccuuggacccgaaagauggugaacuaugcuuggauagggugaagccagaggaaacucugguggaggcucgcugacgugcaagaucgucaaaucugagcaugggggcgaaagacuaaccaucuaguagcugguuaccgccgaaguuucccucaggauagcagugucgaccuucaguuuuaugagguaaagcgaaugaacuuuaaauauguaagaagcccuuguuacuuaacugaacgugggucgaauguaucgacacuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacgcgggguuaaggugccggaguggacgcucaucagacaccacaaaaggcguuaguacaucuugacagcaggacgguggccauggaagucggaauccgcuaaggacuguguaacaacucaccugccgaauguacuagcccugaaaauggauggcgcucaagcgucccacccauaccccgcccucaggguagaaacgaugcccugaggaguaggcggccguggaggucagugacgaagccuagggcgugagcccgggucgaacggccucuagugcagaucuuggugguaguagcaaauacuucaaugagaacuugaaggaccgaaguggggaaagguuccaugugaacagcgguuggacauggguuagucgauccuaagccauagggaaguuccguuucaaaggggcacucgugccccguguggcgaaagggaagccgguuaauauuccggcaccuggauguggguuuugcgcggcaacgcaacugaacgcggagacgacggcgggggccccgggcagaguucucuuuucuucuuaacggucuaucacccuggaaacaguuugucuggagauaggguuuaauggccggaagagcccgacacuucugucggguccggugcgcucucgacgucccuugaaaauccgcgggagggaauaauucucacgccaggucguacucauaaccgcagcagguccccaaggugaacagccucugguugauagaacaauguagauaagggaagucggcauccguaacuucgggaaaagggcucuaaggguugggcacguugggcuuugggcggacgcccugggagcagagggccucuagccgggcaaccggccggcggcccucagcacccgggguugaagcccuuagcccggcgugcgguuaacaaccaacuuagaacugguacggacagggaaucugacgucuauagcauugcgauggccagaaagugguguugacgcaaugugucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaaaugccucgucaucuaauuagugacgcgcauggauaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcaaaaucagcggggaagacccuguugagcuugacucuaguuugacauugugaaaagacauaggagguguagaauaggugggagcuucggcgccagugaaauaccacuacuccuauuguuuuuuuacuuauucaaugugaagacauugucagguggggaguuccuuuagucccucgaaauuugaggcuagaggagaaaaguuaccacagggauaacuggcuuguggcggccaagcguagcgacgucgcuucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaaagcuggggaccgucgugagacagguuagucccuacugaugaacucgucgcaaugguaauucagcuuaguacgagaggaaccgcugauucagauaauugguuuuugcgguuguccgaccgggcagugccgcgaagcuaccaucugcuggauaauggcugaacgccucuaagucagaauccaugccagaacgcgacgauacuacccgcacguuguagacguauaagaauaggcuccggccucguauccuagcaggcgauuccuccgccggccucgaaguggccgucgguaauucgcguauugcaauuuagacacgcgcgggaucaaauccuuugcagacgacuuagaugugcgaaaggguccuguaagcaguagaguagccuuguuguuacgaucugcugaggguaagcccuccuucgccuagauuuc ........................<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..<<<..<<.......<<.<<<....>>>.>>.......>>....<<<<<.<<<<<<<<<..<<<<<<..<<....<<<<......>>>>.((......<<<.....))>>>....>>..>>>.>>>..>>>>....>>>>>>>>.>>........<<<<<<<........>>>>>>>.....<<<<<<......>>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<.<<<<<<.<...<<.<<<<<<<<<.....<<<<<<....>>>>>>......>>>>>>>>>.>>.<<<<<<<.<<<<<<<<<<<<<<<.....<.<<<<<<<<......<<<<<<..>>>>>>.......>>>>>>>>....>.>>>>>>>>>>>>>>>........<<...>>.....>>>>>>>....>>>>>>>.>>>>..<<<<.<....>.>>>><<<<<<....<<<<<<<<.<<<<..<<<...<<<<.....>>>>...>>>....<<<<<..<<....>>...>>>>>.<<<<<<<<..............>>>.>>>.>>....>>>>.>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<...<<<<<<<....>>>>>>>....>>>>..<<<<<........>>>>>..>>>>>>>>>..<<.<....>.>>.>>>>>>......>.>>...<<<<<....<.<<<....>>>.><<<<<<<<<<....<<.<<<<<<<.....<<<........>>.>.....>>>>>....<<<.<<<<.<......>>>>>.>>>...>>>>..>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<......<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>....>>>>>>.>>>...>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<...<<<....>>>........<<<<<......>>>>>....>>>....>>...<<<<<........>>>>>))<<<<.<<<<.<<<....<<<....>>>.......<<<<<<...<<<<.<<<<<<<<<<<<<.<<<<...((..>>>>.><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<<....>>>>>>>>>>>>.>.>>>>>>>.>>>>.........>>>>>>.........>>>...>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.......<..<<<<<<.<.<<.................<<<<<.<<<<<..<.<<<..<<<<....<<<<<<<<.<<.<<<<<<<.<<.<<<<<....>>>>>.>>.>>>>>>>.>>.>>>>>>>>....>>>>..>>>>...>>>>>......>>>>>......>>...>.>>>>>>..<<<<<<<<<..<<<<...<<<<<<<....<<<<.....>>>>......>>>>>>>...<<<<<.<<<<<.<<<<<.<<........>>.>>>>>....>>>>>>>>>>..<<<<..<<<<<<.......>>>>>>.>>>>>>>>..>>.>>>>>>>.>...>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<....<<<<<<.<<<<<<.<<<<<.<<<<<<<<..<<<<<<<<<<<<<<<<<..........<<<<<..<<....>>............>>>>>.>>>>>>>.>>>>>>>>>>...<<<<...>>>>.....>>>>>>>>..>>>>>.<<<<<<<..<<<<<.....>>>>>>>>>>>>....>>>>>.>.>>>>>>.............<<<<<<...<<...>>...>>>>>><<<<<<.<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>.>>>>>>.<<<<<<<....>>>.>>>>....>>>.>>>>>....<<<<<<<..<<<<.<.<<<<<.................>>>>>.><<<<<...<<<<....<<<<<<<<<<))..>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>.....<<<<<.<<.<<<......<<.......<<<....>>>....>>........<<<<.....<<<.<<<<<.......>>>>>.>>>....>>>>..............>>>>>.>>>>>...<<<<<<<.............>>....<<<<<<<<<.<<<....<<<<.<..<<<<<......>>>>>..>>>>>...>>>....>>>>..>>>>>...>>>>>. ........................(((((......(......).......)))).).........((....))...((((......((.....)).....))))...((((.........(((.(((....))).))....)........(((((.(((((((((..((((((..((..({((((......)))))[[(...).(((....}]])))....))..)).))))..))))....)))))))).))...)....(((((((........))))))).....(((((........)))))..)))..................................((....))............(..((((....))))............).....................((((.((((((.....((.((((((((((....((((((....)))))).....)))))))))).)).(((((((((((((((((((((((.......((((((((......(((((....))))).......))))))))......)))))))))))))))........((...))....)))))))).....)))))).))))..((((........))))((((((..(.((((((((.((((..(((...((((.....))))...)))....(((((..((....))...))))).((((((((....(....)....))).))).))....)))).))))))))..((.(...((((((...(.(((((((((..((((...(((((((....)))))))....))))..(((((........)))))..)))))))))).((.(....).)).))))))......).)))..(((((....(.(((....))).)((((((((((....((.((((((......(((........)).)......))))....(((.((((.(......))))).)))...))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(....{.....(((.((((((((((.....<.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((..(((((((...((.....)).))))))....[[(((.((...(((...(((....)))........(((((......)))))....)))....))...(((((........)))))]]((((.((((((((...((((....)))...(...((((((...((((.(((((((((((((.((((...[[..)))).)(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....))).).)))))))).))).))).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(..((((((.(.((.................(((((.(((((..(..((..((((.....(((((((.((.(((((((.((.(((((....))))).)).))))))).)).))))))).....))))..)).)...)))))......)))))......))...).))))))..(((((((((..((((....((((((....((((.....))))......))))))..(.(.(((.(((((.(((((.((........)).)))))....)))))))).)).(((.(.(((((.(......)))))).))))))))..)).))))))).)..))).)))))))..))))))....)).[..(((((......].)))))....(((((..(((....((((((.((((((.(((((.((((((((..(((((((.(((((((((.......[...((.(..((....))..........]..)))..))))))).)).)))))))...((((...)))).....))))))))..))))).(((.(((..((((.(...).))))))).)))....))))).).)))))).......}.....((((((...((...))...)))))).(((((.(((((..(.(((((((......))))))..).).(((.........))).....))))).)))))..(((((((....))).))))....))).)))))....(((((((..(((..(.(((((......(....).....))))).)(((((...((((....((((((((((]]..)))))..)))))...))))..))))).((((...((((.....>.......))))...))))..)))....))))))).....(((((.((.(((....(.((.......(((....)))....))).......((((.....(((.(((((.......))))).)))....))))..............))))).)))))...(((((((..(.......)..))..(.(((((((((.(((....((((([..((((.(.....)))))).]))))...)))....))))..))))))..))))). Cryo-EM structure of a Chaetomium thermophilum pre-60S ribosomal subunit - State Puf6; RNA (3341-MER) 8ia0 C2 256 2.7 RF00002 URS0002681404_759272 37129998 0003735 0005840 759272 aaacuuucaacaacggaucucuugguucuggcaucgaugaagaacgcagcgaaaugcgauaaguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgcccgccgguauuccggcgggcaugccuguucgagcgucauuucaaccaucaagcccugggcuuguguuggggacccgcggcugcucgcgggcccugaaaagcaguggcgggcucgcuggcgggugccagccguaaaaccc .........................................<<<<<<<<<....>>>>.....<.<<<......>>..............>>>..>...>>>....<<.....>><<<<<<<<<....>>>>>>>>>............................<<<<<<...>>>>>>....<<<<.<<<<<<<....>>>>>>>>>>>..........<<<<<<<<<<<..>>>>>>.>>.>>>......... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))............................((((((...))))))...(((((.((((((......))))))))))..).......(((((((((((())))))).)).)))......... Cryo-EM structure of a Chaetomium thermophilum pre-60S ribosomal subunit - State Puf6; RNA (319-MER) 8id2 C 24 1.8 URS00023358B8_9606 37094335 9606 ggggacugcguucgcgcuuucccc <<<<<..<<<....>>>..>>>>> (((((..(((....)))..))))) Crystal structure of the ubiquitin-like domain in the SF3A1 subunit of human U2 snRNP complexed with the stem-loop 4 of U1 snRNA; RNA (5'-R(*GP*GP*GP*GP*AP*CP*UP*GP*CP*GP*UP*UP*CP*GP*CP*GP*CP*UP*UP*UP*CP*CP*CP*C)-3') 8id2 D 24 1.8 URS00023358B8_9606 37094335 9606 ggggacugcguucgcgcuuucccc <<<<<..<<<....>>>..>>>>> (((((..(((....)))..))))) Crystal structure of the ubiquitin-like domain in the SF3A1 subunit of human U2 snRNP complexed with the stem-loop 4 of U1 snRNA; RNA (5'-R(*GP*GP*GP*GP*AP*CP*UP*GP*CP*GP*UP*UP*CP*GP*CP*GP*CP*UP*UP*UP*CP*CP*CP*C)-3') 8idt 5 120 2.8 RF00001 URS000002B0D5_9606 37491604 0003735 0005840 9606 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. human nuclear pre-60S ribosomal particle - State G; 5S rRNA 8idt 8 156 2.8 RF00002,RF02540 URS00004B2C76_9606 37491604 0003735 0005840 9606 cgacucuuagcggnggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<.<<.....>>>.....(.<<<......>>.............>>>..)...>>>....<<....>><<<<<<<<<.....>>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))(((((((((.....))))))))).................... human nuclear pre-60S ribosomal particle - State G; 5.8S rRNA 8idt 2 3524 2.8 RF02543 URS000268145C_9606 37491604 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugagnccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaanggaaaguugaaaagaacuuugaagngagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcggcccggcggaucuuucccgcgcgggggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcunggaaggcccggcggggaagguggcucgggggcccccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcncucuccccccucccggcgcgccggggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccgggggaggccacgcgcgcgucccccgaagagggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccnucuugaaacncggaccaaggagucuaacacgngcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgagggngcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuagnacccnanagauggugancuaugccugggcagggcgaagccagaggaaacucuggugnagguccguagcgguccugacgugcaaaucgnucguccgaccuggguauagnggcgaaagacuaaucgaaccaucuaguagcuggnucccuccgaaguuucccucaggauagcuggcgcucucgcagacccgacgcccgccacgcaguuuuauccgguaaagcuuuaaaungguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacnuuuggnaagcngaacuggcgcuncgggaugaaccgaacgccggguuaangcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggaugncgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagcggcggcccggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcgnugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguagunnnaaauauucaaacganaacuuugaaggccgaaguggngaaggguuccaugugaacagnanuugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucgnguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccggggnagaggguguaaaucucgcnccgggccguaccnauauccgcagcaggucuncaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagcnggauccguaacuucgggauaaggauuggcucuaagggcugggucggucgcggccggcgccuagcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugccnagugcucugaaugucanagugnagaaauucaaugaagcgcggguaaacggcgugancgagauucccacugucccuaccuacuauccagcgaaaccacngncaagggaacgngcuuggnggaaucagcngngaaagaaganccuguugagcuugacucuagucuggcacggugaagagacuuuuuucacugacccggngaggcgggggggcgagccccgaggggcucucgcuucuggcgccaancgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccaggugggnaguuugacugnggcgguacaccugucaaacgguancgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucungauuuucagnacgaauacagaccgugaaagcggggccunacgauccuucugaccuuuungguuuuaagcaggannugucagaaaaguuaccacagggauacuuguggcggccangcguucauagcgacgucgcuuugaugucggcucuuccuaucauugunaagcagaauunaccaagcguungauuguucacccacuaauagggaacgugngcuggnnuuagancgucgugagacagnuuaguuuuacccuncugaugnuguguuguugccaugguaauccugcncaguacgagaggaaccgcagguncanacauuugguguaunugcuuggcugaggagccaauggggcgaagcuacnaucugugggauuaugacunaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccggucccccgccgggguccgguncngagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..[[[..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>>..<<<<<<<<<<...<<.<<<<<........<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>...>>>>>.>>..>>>>>>>>>>.......<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<......>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<<<..<<<<<<<..<....<<....<<<<.<<<..<<......>>>>>>>>>>>...>..>>>>...>>>>>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<<<<<<<<<<<<<<<<<...<<..<<<..<.<<<<......<<<<<<<<..>>>>>>>>.......>>>>.>.>>>........>>>>>>..>>>>>>>>>>>....................<<<<<..<<<<<<<............>>>>>>>.<<<<<<.<<<<.<<<<<<<<<<.<<<<<<.<<<<<.<...........>..>>>>>.>>>>>.>.>>>>>>>.>>>...>>>>..>>>>.>>..<<<<<<<<<.......>>>>>>>.>>.....>>>>>.....>>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<......>>>>>>>..<<<<<...<<<..<<<..[......[.>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<......................<<<.<<<<<<<<....<<...>>....>>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>>>>>>.>>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<...........]......]............................>>>>>>>>>....>>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<<....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<....<<.....>>..>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<..<<...>>..>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<...<<<<<<<....>>>>>>>...<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<<<<<<<<<<<<..{{{..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>.>.>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<.......................>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>.......<<<..<<<<<.<...<<<.....<<<<....>>>>.....>>>.>>>>..>>>>>.....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>...>>>....<<<<<........>>>>>....[[[[[..{{{........[[[[[.{{[[[[..<<<<<.<<<<<<<<<.<<<<<<<<...>>>>>>>>...<<<<<.....<<<<........<<....>>.....................<<<<<<<<<<.......>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))]......((((((..(((..>>>>>>.)))))))))..........]]]]..}}]]]]]........<<<<<<...<<.......>>...>>>>>>..((...<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.....))..>>>.....>>>>>..>...>>>>......<<<<<<<....>>>.>>>>........}}}.]]]]].....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<.}}}..>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.....<<<<<<..<<..<<<<....<<<........<<<<<.<<<<....>>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>..............>>>>..>>.>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<.<..<<<<<......>>>>>..>>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((...((((((((((.....)))))).)))).....)))....((((((((((...((.(..((...(....((((((((..({((((......)))))....[[(...).(((....}]])))...).))))))))..))..).))..))))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....(((((((((((..((((((...(....((....((((.((...((......)).))))))))...)...)))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((..(.((((......(.(((((....))))).).......)))).).)))........))))))..)))))))))))....................((((((.((((((..............)))))).((((((.(.((.(((((((((((.(((((.(((...(...........)....))).))))).).))))))).)))...)).)..)))).))..((((((((.........)))))).))..[.)))))).....))).)))))...)))))...)))))))).<((((........))))((((((..(.(((((((((((((..(((..((((..........)))..)..)))...((....))...(((((.(......).)))))..(((((...(((..(((..[.......[)))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))..).))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((.(((((((......................(((.((((((((....((...))....))))))...(((((((((.(......))))))))))....))))))))))))..))..((((..((((.....))))..))))....(((......)))...(((((((...((([[[.....(.(((((......(..........(((.((((((((((.....{.(((((.(.(...((.........))...).).....(...((......)).).)))))...)))))))))))))..........]]].)....)))))).)))...)))))))((((((.(((..........].......]]..............(...)........)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...((....(((....)))..........((.((((.............))))))......))....))...(((((........)))))]]((((....(((((...((.(.(......).).))..((((....)))...(...((((((...(((((((((((((((((((((((..{{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....(((((((.......))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((...(.(.......))........)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].....(((..((((((.(...((.....((((....)))).....)).)))))..))))).....)).))))))).)..))).)))))))..))))))....)).[...((((.....>].)))).....(((((..((((.......(((((.((((((..(((((.(((((((((.(((((((.....)))))))...(((((.....((((.....................................((((((((((.......))))))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))))........((((((...((.......))...))))))...[....(((.((((((..(.(.((((........))))...).).(((.....]...))).....)))))..)...))).......(((((((....))).))))..a..)..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}}.)))))..)).))...))))...)))).((((...((((.....}.......))))...))))..)))...).)))))).....((((((..((..((((.(..(((........(((((.((((....)))).))))).......)))...((...(((.....((((.(((((((......)))))))))))....)))...))...........)..))))..)).))))))(((((.(..(.......)..)....((.(((((((.((.....((((.(..(((((......)))))..)))))....))....)))).))).))..))))).. human nuclear pre-60S ribosomal particle - State G; 28S rRNA 8idy 5 120 3.0 RF00001 URS000002B0D5_9606 37491604 0003735 0005840 9606 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. human nuclear pre-60S ribosomal particle - State F; 5S rRNA 8idy 8 156 3.0 RF00002,RF02540 URS00004B2C76_9606 37491604 0003735 0005840 9606 cgacucuuagcggnggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<.<<.....>>>.....(.<<<......>>.............>>>..)...>>>....<<....>><<<<<<<<.......>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))(((((((((.....))))))))).................... human nuclear pre-60S ribosomal particle - State F; 5.8S rRNA 8idy 2 3641 3.0 RF02543 URS000268145C_9606 37491604 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugagnccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaanggaaaguugaaaagaacuuugaagngagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcggcccggcggaucuuucccgcgcgggggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcunggaaggcccggcggggaagguggcucgggggcccccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcncucuccccccucccggcgcgccggggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccgggggaggccacgcgcgcgucccccgaagagggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccnucuugaaacncggaccaaggagucuaacacgngcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgagggngcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuagnacccnanagauggugancuaugccugggcagggcgaagccagaggaaacucuggugnagguccguagcgguccugacgugcaaaucgnucguccgaccuggguauagnggcgaaagacuaaucgaaccaucuaguagcuggnucccuccgaaguuucccucaggauagcuggcgcucucgcagacccgacgcccgccacgcaguuuuauccgguaaagcuuuaaaungguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacnuuuggnaagcngaacuggcgcuncgggaugaaccgaacgccggguuaangcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggaugncgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagcggcggcccggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcgnugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguagunnnaaauauucaaacganaacuuugaaggccgaaguggngaaggguuccaugugaacagcanuugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucgnguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccggggnagaggguguaaaucucgcnccgggccguaccnauauccgcagcaggucuncaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagcnggauccguaacuucgggauaaggauuggcucuaagggcugggucggucgcggccggcgccuagcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugccnagugcucugaaugucanagugnagaaauucaaugaagcgcggguaaacggcgugancgagauucccacugucccuaccuacuauccagcgaaaccacngncaagggaacgngcuuggnggaaucagcngngaaagaaganccuguugagcuugacucuagucuggcacggugaagagacaugagagguguagaauaagugggaggcccccggcgcccccccgguguccccgcgaggggcccggggcgggguccgccggcccugcgggccgccggugaaauaccacuacucugaucguuuuuucacugacccggngaggcgggggggcgagccccgaggggcucucgcuucuggcgccaancgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccaggugggnaguuugacuggggcgguacaccugucaaacgguancgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucungauuuucagnacgaauacagaccgugaaagcggggccunacgauccuucugaccuuuungguuuuaagcaggannugucagaaaaguuaccacagggauacuuguggcggccangcguucauagcgacgucgcuuugaugucggcucuuccuaucauugunaagcagaauunaccaagcguungauuguucacccacuaauagggaacgugngcuggnnuuagancgucgugagacagnuuaguuuuacccuncugaugnuguguuguugccaugguaauccugcncaguacgagaggaaccgcagguncanacauuugguguaunugcuuggcugaggagccaauggggcgaagcuacnaucugugggauuaugacunaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccggucccccgccgggguccgguncngagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<<....<<....>>.....>>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..[[[..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>>..<<<<<<<<<<...<<.<<<<<........<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>...>>>>>.>>..>>>>>>>>>>.......<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<......>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<<<..<<<<<<<..<....<<....<<<<.<<<..<<......>>>>>>>>>>>...>..>>>>...>>>>>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<<<<<<<<<<<<<<<<<...<<..<<<....<<<<......<<<<<<<<..>>>>>>>>.......>>>>...>>>........>>>>>>..>>>>>>>>>>>....................<<<<<..<<<<<<<............>>>>>>>.<<<<<<.<<<<.<<<<<<<<<<.<<<<<<.<<<<..<...........>...>>>>.>>>>>.>.>>>>>>>.>>>...>>>>..>>>>.>>..<<<<<<<<<.......>>>>>>>.>>.....>>>>>.....>>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<......>>>>>>>..<<<<<...<<<..<<<..[[....(((>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<......................<<<.<<<<<<<<....<<...>>....>>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>>>>>>.>>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<..........)))....]]............................>>>>>>>>>....>>>>>>.<<<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>.>>.....>>>>>><<<....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<....<<.....>>..>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<..<<...>>..>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<..<<<<<.<<....>>.>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<<<<<<<<<<<<..{{{..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>.>.>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<.<<<<<<<<<<<.......................>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>.......<<<..<<<<<.<...<<<.....<<<<....>>>>.....>>>.>>>>..>>>>>.....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>...>>>....<<<<<........>>>>>....[[[[[..{{{........[[[[[.{{[[[[..<<<<<.<<<<<<<<<.<<<<<<.<........................................<<.........<.....>......>>......................................................>.>>>>>>...<<<<<.....<<<<........<<....>>.....................<<<<<<<<<<.......>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>.<<<<<<<...........>>>>>>>.<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))]......((((((..(((..>>>>>>.)))))))))..........]]]]..}}]]]]]........<<<<<<...<<.......>>...>>>>>>..((...<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.....))..>>>.....>>>>>..>...>>>>......<<<<<<<....>>>.>>>>........}}}.]]]]].....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<}}}.>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.....<<<<<<..<<..<<<<....<<<........<<<<<.<<<<....>>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>..............>>>>..>>.>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<.<..<<<<<......>>>>>..>>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((...((((((((((.....)))))).)))).....)))....((((((((((...((.(..((........((((((((..({((((......)))))....[[(...).(((....}]])))...).)))))))...))..).))..))))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....(((((((((((..((((((...(....((....((((.(((..((......)))))))))))...)...)))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((..(.((((......(.(((((....))))).).......)))).).)))........))))))..)))))))))))....................((((((.((((((..............)))))).((((((.(.((.(((((((((((.(((((.(((...(...........)....))).))))).).))))))).)))...)).)..)))).))..((((((((.........)))))).))..[.)))))).....))).)))))...)))))...)))))))).<((((........))))((((((..(.(((((((((((((..(((..((((..........)))..)..)))...((....))...(((((.(......).)))))..(((((...(((..(((..[.....[.[)))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))..).))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((.(((((((......................(((.((((((((....((...))....))))))...(((((((((.(......))))))))))....))))))))))))..))..((((..((((.....))))..))))....(((......)))...(((((((...((([[[.....(.(((((......(..........(((.((((((((((.......(((((.(.(...((.........))...).).....(...((......)).).)))))...)))))))))))))..........]]].)....)))))).)))...)))))))((((((.(((..........].].....]]..............(...)........)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...((....(((....)))..........((.((((.............))))))......))....))...(((((........)))))]]((((....(((((...((.(.(......).).))..((((....)))...(...((((((...(((((((((((((((((((((((..{{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....(((((((.......))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((...(.(.......))........)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].....(((..((((((.(...((.....((((....)))).....)).)))))..))))).....)).))))))).)..))).)))))))..))))))....)).[...((((.....>].)))).....(((((..((((.......(((((.((((((..(((((.(((((((((.(((((((..........................................................................................................................)))))))...(((((.....((((.....................................((((((((((.......))))))))))..))))..)))))....)))))))))..)))))...(((.....))).(((((((...........)))))))[((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].......((((((..(((..]]]]]].))))))))).....}....))))..)))))))........((((((...((.......))...))))))...[....(((.((((((..(.(.((((........))))...).).(((.....]...))).....)))))..)...))).......(((((((....))).))))..a..)..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}}.)))))..)).))...))))...)))).((((...((((.............))))...))))..)))...).)))))).....((((((..((..((((.(..(((........(((((.((((....)))).))))).......)))...((....((.....((((.(((((((......)))))))))))....))....))...........)..))))..)).))))))(((((.(..(.......)..)....((.(((((((.((.....((((.(..(((((......)))))..)))))....))....)))).))).))..))))).. human nuclear pre-60S ribosomal particle - State F; 28S rRNA 8ie3 5 120 3.3 RF00001 URS000002B0D5_9606 37491604 0003735 0005840 9606 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<.....<.....>..>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. human nuclear pre-60S ribosomal particle - State E; 5S rRNA 8ie3 8 156 3.3 RF00002,RF02540 URS00004B2C76_9606 37491604 0003735 0005840 9606 cgacucuuagcggnggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<.<<.....>>>.....(.<<<......>>.............>>>..)...>>>....<<....>><<<<<<<<<.....>>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))(((((((((.....))))))))).................... human nuclear pre-60S ribosomal particle - State E; 5.8S rRNA 8ie3 2 3519 3.3 RF02543 URS000268145C_9606 37491604 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugagnccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaanggaaaguugaaaagaacuuugaagngagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcggcccggcggaucuuucccgcgcgggggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcunggaaggcccggcggggaagguggcucgggggcccccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcncucuccccccucccggcgcgccggggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccgggggaggccacgcgcgcgucccccgaagagggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccnucuugnaacncggaccaaggagucuaacacgngcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgagggngcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuagnacccnanagauggugancuaugccugggcagggcgaagccagaggaaacucuggugnagguccguagcgguccugacgugcaaaucgnucguccgaccuggguauagnggcgaaagacuaaucgaaccaucuaguagcuggnucccuccgaaguuucccucaggauagcuggcgcucucgcagacccgacgcccgccacgcaguuuuauccgguaaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuugguaacagaacuggcgcuncgggaugaaccgaacgccggguuaangcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggaugncgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagcggcggcccggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcgnugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguagunnnaaauauucaaacganaacuuugaaggccgaaguggngaaggguuccaugugaacagnanuugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucgnguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcnccgggccguaccnauauccgcagcaggucuncaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcugggucggucgcggccggcgccuagcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugccnagugcucugaaugucanagugnagaaauucaaugaagcgcggguaaacggcaagaugancgagauucccacugucccuaccuacuauccagcgaaaccacngncaagggaacgngcuuggnggaaucagcngngaaagaagacccuguugagcuugacucuagucuggcacggugaaguuuuuucacugacccggngaggcgggggggcgagccccgaggggcucucgcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccaggugggnaguuugacngnggcgguacaccugucaaacgguancgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuungguuuuaagcaggannugucagaaaaguuaccacagggauauuguggcggccangcguucauagcgacgucgcugaugucggcucuuccuaucauugunaagcagaauunaccaagcguungauuguucacccacuaauagggaacgugngcuggnnuuagancgucgugagacagnuuaguuuuacccuncugaugnuguguuguugccaugguaauccugcncaguacgagaggaaccgcagguncanacauuugguguaunugcuuggcugaggagccaauggggcgaagcuacnaucugugggauuaugacunaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccggucccccgccgggguccgguncngagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..[[[..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>>..<<<<<<<<<<...<<<<<<<<........<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>...>>>>>>>>..>>>>>>>>>>.......<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<......>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<<<..<<<<<<<.......<<....<<<<.<<<..<<.<..>.>>>>>>>>>>>......>>>>...>>>>>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<.<<<<<<<<<<<<<<<...<<..<<<....<<<<......<<<<<<<<..>>>>>>>>.......>>>>...>>>........>>>>>>..>>>>>>>>>>>....................<<<<<<.<<<<<<..............>>>>>>.<<<<<<.<<<<.<<<<<<<<<<.<<<<<<.<<<<<<............>..>>>>>.>>>>>.>.>>>>>>>.>>>...>>>>..>>>>.>>..<<<<<<<<<.......>>>>>>>.>>....>>>>>>......>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<......>>>>>>>..<<<<<...<<<..<<<.........[[>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<......................<<<.<<<<<<<<<...<<...>>...>>>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>>>>>>.>>>..<<<<.<<<<<....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<..<<....<<.........>>....>>.........<<......>>....>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<..........]]...................................>>>>>>>>>....>>>>>>.<<<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>.>>.....>>>>>><<<....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<....<<.....>>..>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<..<<...>>..>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<...<<<<<........>>>>>...<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<<<<<<<<<<<<..{{{..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>.>.>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<...............>>>>><<.<<<<<<<<<<<.......................>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>.......<<<..<<<<<<....<<<....<<<<<....>>>>.>...>>>.>>>>..>>>>>........>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>...>>>....<<<<<........>>>>>....(((((..{{{........(((((.{{[[[[..<<<<<.<<<<<<<<<.<<<<<.....>>>>>...<<<<<.....<<<<.....<..<<....>>....>.................<<<<<<<<<.......>>>>>>>>>...>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>.......<<<<<<....<<<<<<.......>>>>>>.....<<....((>>.....>>>>>>........<<<<.......>>>>......<<<....>>>...))........(((((...(((..>>>>>>.))).)))))..........]]]]..}}))))).......<<<<<<...<<.......>>...>>>>>>.....<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>>......<<<<<<<....>>>.>>>>........}}}.))))).....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<.}}}..>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.....<<<<<<..<<..<<<<....<<<........<<<<<.<<<<....>>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>..............>>>>..>>.>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<.<..<<<<<......>>>>>..>>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((...((((((((((.....)))))).)))).....)))....((((((((((...((.(..((...(....((((((((..({((((......)))))....[[(...).(((....}]])))...).))))))))..))..).))..))))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....(((((((((((..(((((((.......((....((((.((....(.(..).)..))))))))......))))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((..(.((((......(.(((((....))))).).......)))).).)))........))))))..)))))))))))....................((((((.((((((..............)))))).((((((.(.((.(((((((((((.((((..(((....(..........)....)))..)))).).))))))).)))...)).)..)))).))..((((((((.........)))))).))..[.)))))).....))).)))))...)))))...)))))))).<((((........))))((((((..(.(((((((((((((..(((..((((..........)))..)..)))...((....))...(((((.(......).)))))..(((((...(((..(((..[........)))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((.(...(((((((....)))))))...)<.))...(((..((.((.......A)))).)))..).))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((.(((((((......................(((.((((((((....((...))....))))))...(((((((((.(......))))))))))....))))))))))))..))....((..((((....))))..))......(((......)))...(((((((...((([[[.....(.(((((......(..........(((.((((((((((.....{.(((.(.(.(...((.........))...).).....(...((......)).)..))))...)))))))))))))..........]]].)....)))))).)))...)))))))((((((.(((..................]]..............(...)........)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...((....(((....)))..........((.((((.............))))))......))....))...(((((........)))))]]((((....(((.....((.((........)).))..((((....)))...(...((((((...(((((((((((((((((((((((..{{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....(((((((.......))))))))))).).))))))))))))(...)....))))))...).)...........))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((.......................)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(...(((..((((((.....(......((((....))))......)..))))..)))))...)....)).))))))).)..))).)))))))..))))))....)).[...((((.....>].)))).....(((((..((((........((((.((((((..(((((.(((((((((.(((((.....)))))...(((((.....((((.....................................((((((((((.......))))))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([.(...((((((..(.((((((.......))))))...).((]...[[)).....))))))....(....(((.......)))....)..(((....))).).]].........(.(....(((..]]]]]].)))..).).....).....))))..))))))........((((((...((.......))...))))))......(((.((((((..(.(.((((........))))...).).(((.(.....).))).....)))))..)...))).......(((((((....))).))))..a..)..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}}.)))))..)).))...))))...)))).((((...((((.....}.......))))...))))..)))...).)))))).....((((((..((..((((.(..(((........(((((.((((....)))).))))).......)))...(((...((.....((((.(((((((......)))))))))))....))...)))...........)..))))..)).))))))(((((.(..(.......)..)....((.(((((((.((.....((((.(..(((((......)))))..)))))....))....)))).))).))..))))).. human nuclear pre-60S ribosomal particle - State E; 28S rRNA 8ifb A 1519 2.43 RF00177,RF01959,RF02542,RF01960 URS00000ABFE9_562 38227611 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugccggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<...<<<<<<<<<......>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<.>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<..>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((.(........).))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((.(....).))))......)).).....(((....)))....((((((.)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((((())))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....))))))).............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Dibekacin-bound E.coli 70S ribosome in the PURE system; 16S ribosomal RNA 8ifb a 2753 2.43 RF02541 URS00004B0F34_562 38227611 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagcgucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcgcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<<.....>>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<..>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<..>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<..<<....>>...>>>>>..>....>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<..>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((((((.....))))).))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(())...)))..))))).))...........]]].)...))))))))))...)))))))((((((((()))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((())))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Dibekacin-bound E.coli 70S ribosome in the PURE system; 23S ribosomal RNA 8ifb b 119 2.43 RF00001 URS0000049E57_562 38227611 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>> ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))) Dibekacin-bound E.coli 70S ribosome in the PURE system; 5S ribosomal RNA 8ifb 5 76 2.43 RF00005 URS00005AA258_562 38227611 0030533 0006412 562 gcccgganagcucagucgguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((.........)))).....((.((..]....)).))))))))).... Dibekacin-bound E.coli 70S ribosome in the PURE system; A-site tRNA-Phe 8ifb 6 77 2.43 RF00005 URS00001BBAFC_562 38227611 0030533 0006412 562 cgcggggnggagcagccuggnagcucgucgggnucauaacccgaagaucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(.(((.......))).)))))))..... Dibekacin-bound E.coli 70S ribosome in the PURE system; P-site tRNA-fMet 8ifb 7 10 2.43 38227611 562 gacauguuca .......... .......... Dibekacin-bound E.coli 70S ribosome in the PURE system; mRNA 8ifc A 1519 2.9 RF00177,RF01959,RF02542,RF01960 URS00000ABFE9_562 38227611 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugccggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<...<<<<<<<<........>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<.>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<..>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((.((.(........).))..)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((..((.))..)).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((((())))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..((..(((....)))..)).............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Arbekacin-bound E.coli 70S ribosome in the PURE system; 16S ribosomal RNA 8ifc a 2753 2.9 RF02541 URS00004B0F34_562 38227611 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagcgucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcgcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu 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.(((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......((((.((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))).))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((((((.....))))).))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(..)...)))..))))).))...........]]].)...))))))))))...)))))))((((((((()))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((())))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).)))))))).. Arbekacin-bound E.coli 70S ribosome in the PURE system; 23S ribosomal RNA 8ifc b 119 2.9 RF00001 URS0000049E57_562 38227611 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>> ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))) Arbekacin-bound E.coli 70S ribosome in the PURE system; 5S ribosomal RNA 8ifc 5 76 2.9 RF00005 URS00005AA258_562 38227611 0030533 0006412 562 gcccgganagcucagucgguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((.........)))).....((.((..]....)).))))))))).... Arbekacin-bound E.coli 70S ribosome in the PURE system; A-site tRNA-Phe 8ifc 6 77 2.9 RF00005 URS00001BBAFC_562 38227611 0030533 0006412 562 cgcggggnggagcagccuggnagcucgucgggnucauaacccgaagaucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(.(((..]....))).)))))))..... Arbekacin-bound E.coli 70S ribosome in the PURE system; P-site tRNAf-Met 8ifc 7 10 2.9 38227611 562 gacauguuca .......... .......... Arbekacin-bound E.coli 70S ribosome in the PURE system; mRNA 8ifd 1A 3717 2.59 RF02543 URS0000E60B81_9606 38227611 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcggcccggcggaucuuucccgcgcgggggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucgggggcccccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcgcucuccccccucccggcgcgccggggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccgggggaggccacgcgcgcgucccccgaagagggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcagacccgacgcccgccacgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagcggcggcccggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcugggucggucgucggccggcgccuagcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacaugagagguguagaauaagugggaggcccgggccgccggugaaauaccacuacucugaucguuuuuucacugacccggugaggcgggggggcgagccccgaggggcucucgcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccggucccccgcgggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..[[[..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>>..<<<<<<<<<....<<<<<<<.<<<.....<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>.>>>>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<<<..<<<<<<<..<....<.....<<<<.<<<..<<<....>>>>>>>>>>.>...>..>>>>...>>>>>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<<<<<<<<<<<<<<<<<...<<..<<<....<<<<......<<<<<<<<..>>>>>>>>.......>>>>...>>>........>>>>>>..>>>>>>>>>>>....................<<<<<<.<<<<<<<............>>>>>>>.<<<<<<.<<<<.<<<<<<<<<<<.<<<<<.<<<<..<...........>...>>>>.>>>>>.>.>>>>>>>.>>>...>>>>..>>>>.>>..<<<<<<<<<<.....>>>>>>>>.>>....>>>>>>.....>>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<......>>>>>>>..<<<<<...<<<..<<<..[[[..((((>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<......................<<<.<<<<<<<<<...<<<....<<<..<.<<<<.<..<.............>.>>>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.........>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<..........<..................................................>......>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<..........))))..]]]............................>>>>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<....<....>...>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<....<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<<<<<<<<<<<<..{{{..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>.>.>>>>>>>>>>>>.........>>>>>>>..>.............>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<.<<<<<<<<<<<........................>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<............>>>.........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<<.<<<<<<<<<<..........................<....>............................>>>>>>>>>>...<<<<<.....<<<<.........<.....>.....................<<<<<<<<<<<.....>>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>><<<<....>>>>>>)))]......((((((..(((..>>>>>>.)))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]].....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<}}}.>>>>>..>>.>>...>>>>...>>>><<<<....<<<<<...........>>>>>....>>>>.>>>...>.>>>>>>.....<<<<<<<.<...<<<.....<<.........<<<<<..<.......>..>>>>>........>>..........<<....<<<<.<<<<<<<......>>>>>>>>>>>....>>....................>>>...>.>>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<....<<<<<......>>>>>...>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..(((((((((((.....)))))).))))....))))....(((((((((....(((((((.((......((((((((..({((((......)))))....[[(...).(((....}]])))...).)))))))..)))))))))...)))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....(((((((((((..(((((((.......((....((((.(((...(......).)))))))))......))))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((..(.((((......(.(((((....))))).).......))))..))))........))))))..)))))))))))......{.............((((((.(((((((............))))))).((((((.(..(((((((((((((.((((..(.((..................)).)..)))).).))))))).)))...)).)..)))).))..(((((((((.......))))))).))..[.)))))).....))).)))))...)))))...)))))))).<((((........))))((((((....(((((((((((((..(((..((((..........)))..)..)))...((....))...(((((.(......).)))))..(((((...(((..(((..[.....[[[)))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((........)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((......................(((.((((((((....(((....(((..(.(((..(..................).))).)..)))..)).)....))))))...(((((((((.(......))))))))))....))))))))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.......(...(.................................................)..)...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((........}.]]].....]]...........................)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...((..(.(((....))).....)....((.(.((....(....)...)).)))......))....))...(((((........)))))]]((((....(((.....(((((((....)))))))..((((....)))...(...((((((...(((((((((((((((((((((((..{{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...))............))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((........................)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(...(......((((....))))......).)))))..))))).(..............)..........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.(((((((((.(((((.(..(............................................................)..).)))))...(((((.....((((.....(..............)................(((((((((((.....)))))))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(...(((((......))))).....).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))....))..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}}.)))))..)).))...))))...)))).((((...((((.............))))...))))..)))...).)))))).....((((((..(...((......((..........((((.............)))).........)).........(((....((((.(((((((......)))))))))))....)).)...................))...)..))))))(((((.(..(.......)..)....((.(((((((.((.....((((.(..(((((......)))))..)))))....))....)))).))).))..))))).. Dibekacin-added human 80S ribosome; 28S ribosomal RNA 8ifd 1B 120 2.59 RF00001 URS00000F9D45_9606 38227611 0003735 0005840 9606 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. Dibekacin-added human 80S ribosome; 5S ribosomal RNA 8ifd 1C 156 2.59 RF00002,RF02540 URS0000005270_9606 38227611 0003735 0005840 9606 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<<<<....>>>>.....<.<<<......>>.............>>>..>...>>>....<<....>><<<<<<<<<.....>>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))(((((((((.....))))))))).................... Dibekacin-added human 80S ribosome; 5.8S ribosomal RNA 8ifd 2m 1742 2.59 RF01960,RF02542,RF01959,RF00177 URS0000868520_9606 38227611 0003735 0005840 9606 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucgcuccucucccacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgccccccguggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuccgcgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcgggcguccccgccgccucucggccggggcccgaagcauuuacuuugaaaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggucggcccacggcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<..<.....<<<.<....<<....<<<....................<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<<<....>>>>>>...>>>>....<<<<<...<......>..>>>>>...........<<<<..<<<......>>>.>>>>....>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>>>>.<<.<<<..........>>>.>>.<.<<<..>>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....<<.<<.<<<............>>.>.>>..>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<................................................<<<<<<.<.......<<...<.......>.<<<<.......>>>>...>>......>.>>>..>>>.......<<....<...<<................>>....>...>>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<........>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<........<<........>>..........<<<<<.<....<<<<.........<<..<<........>>..>>.......>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<...........<........>..........>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.....>.>>>>>......>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<.................................>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))(((.((.(((...(.((..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..((....(((.(..................((.....((.(.(.....).).))......)).........((.....(((((......))))).....))....(((((...(......)..)))))...........((((.((((......)))))))).)..)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).).....((.((((((............).)))))..))....(.((.................))......)..((((([[......((((.....((..]])).......)))).)))))..))).)).)))..[......(.([[...(.(.((...(((..(................................................((((((.(.......((..((.......)).(((.......)))....))......).)))..))).......(..(..(....(................).....)..).)....)....(((..(...(...((((..(((.((((((((...((........))......)))))))).))).......((....))...))))..)...)...))..))))...)).)....(((((.....(...((((.........))))...)..)))))......{...(((.((.(((..(.((((((.(((........))))))))).)..)))...((..]]))...))...].))))).).(((......((((....))))....)))...]]].]((.((.(((((((..((..(((((..(((.((.(((......((........))..........(((((.(....(((.(............((........))..........).)))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((...(...(.((..(.............(........)............)..)).)..)..(..(((((.....)))))....)...)))....))).))).....).))))).....).)))))...)).).)).))).(...((.(((........(.......((..((((....))))..))....).........))).))......(.....(.(((..........))).).....)..)..))))).....(..(((((.......)))))..)......))...)))))))))..))..(.(..((.(..((((.((..(.((((((((.(((..((((.((...((.((.(...(....................)..)...)).))...)).))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}........ Dibekacin-added human 80S ribosome; 18S ribosomal RNA 8ife 1A 3717 2.57 RF02543 URS0000E60B81_9606 38227611 0003735 0005840 9606 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.........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..(((((((((((.....)))))).))))....))))....(((((((((....(((((((.((......((((((((..({((((......)))))....[[(...).(((....}]])))...).)))))))..)))))))))...)))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....(((((((((((..(((((((.......((....((((.(((...(......).)))))))))......))))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((..(.((((......(.(((((....))))).).......))))..))))........))))))..)))))))))))....................((((((..(((((..............)))).).((((((.((((.(((((((((((.(((((.((((..................)))).))))).).))))))).)))...))))..)))).))..((((((((((.....)))))))).))..[.)))))).....))).)))))...)))))...)))))))).<((((........))))((((((....(((((((((((((..(((..((((..........)))..)..)))...((....))...(((((.(......).)))))..(((((...(((..(((..[.....[[[)))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((......................(((.((((((((....(((....(((..(.(((..(..................).))).)..)))..)).)....))))))...(((((((((.(......))))))))))....))))))))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((........(..(.................................................).)....)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((..........]]].....]]...........................)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...((....(((....)))..........((.(.((....(....)...)).)))......))....))...(((((........)))))]]((((....(((.....((.((((....)))).))..((((....)))...(...((((((...(((((((((((((((((((((((..{{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...))............))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((........................)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(...(......((((....))))......).)))))..))))).(..............)..........((.(......).(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.(((((((((.(((((.(((..............................................................))).)))))...(((((.....((((.....(..............)................(((((((((((.....)))))))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a.))..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}}.)))))..)).))...))))...)))).((((...((((.............))))...))))..)))...).)))))).....(((((((.(...(((.....((..........((((.............)))).........))..........((....((((.(((((((......)))))))))))....))....................)))...).)))))))(((((.(..(.......)..)....((.(((((((.((.....((((.(..(((((......)))))..)))))....))....)))).))).))..))))).. Arbekacin-added human 80S ribosome; 28S ribosomal RNA 8ife 1B 120 2.57 RF00001 URS00000F9D45_9606 38227611 0003735 0005840 9606 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<.<<<............>>>...>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((..((...(....)...))....))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. Arbekacin-added human 80S ribosome; 5S ribosomal RNA 8ife 1C 156 2.57 RF00002,RF02540 URS0000005270_9606 38227611 0003735 0005840 9606 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<.<<.....>>>.....(.<<<......>>.............>>>..)...>>>....<<<..>>><<<<<<<<<.....>>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))((((((((.......)))))))).................... Arbekacin-added human 80S ribosome; 5.8S ribosomal RNA 8ife 2m 1742 2.57 RF01960,RF02542,RF01959,RF00177 URS0000868520_9606 38227611 0003735 0005840 9606 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucgcuccucucccacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgccccccguggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuccgcgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcgggcguccccgccgccucucggccggggcccgaagcauuuacuuugaaaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggucggcccacggcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<.<..<<....<<<....................<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<<<....>>>>>>...>>>><...<<<<<...<......>..>>>>>........>..<<<<.<<<<......>>>>>>>>....>>>...>>>.>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....<<....<<<............>>.>.....>>......<<.................>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<................................................<<<<<<.<.......<<...<.......>.<<<<.......>>>>...>>......>.>>>..>>>.......<<......<<<<................>>.>>.....>>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<........<<........>>..........<<<<<......<<<<<........<<..<<........>>..>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<...<<...........<........>..........>>...>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.......>>>>>......>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<.................................>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))(((.((.(((...(.((..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..((....((.....................((.....((.(((.....))).))......)).........((.....(((((......))))).....))....(((((...(......)..)))))...........((((.((((......)))))))).....))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).).....((.((.(((............)).).))..))....(.((.................))......)..((((([[......((((.....((..]])).......)))).)))))..))).)).)))..[......(.([[...(.(.((...(((..(................................................((((((.(.......((..((.......)).(((.......)))....))......).)))..)))........(.(..(....(................).....)..).)....)....(((..(...(...((((..((..((((((((...((........))......))))))))..)).......((....))...))))..)...)...))..))))...)).)....(((((.....(...((((.........))))...)..)))))......{...(((.((.(((..(.((((((.(((........))))))))).)..)))...((..]]))...))...].))))).).(((......((((....))))....)))...]]].]((.((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((.(............((........))..........).)))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((...(...(.((...((...........(........)..........))...)).)..)..(..(((((.....)))))....)...)))....))).))).....).))))).....).)))))...)).)))).))).(...((.(((........(.......((..((((....))))..))....).........))).))......(.....(((((..........))))).....)..)..))))).....(.((((((.......)))))).)......))...)))))))))..))..(.(..((.(..((((.((..(.((((((((.(((..((((.((...((.((.(...(....................)..)...)).))...)).))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}........ Arbekacin-added human 80S ribosome; 18S ribosomal RNA 8ine 2 3537 3.2 RF02543 URS000268145C_9606 37491604 0003735 0005840 9606 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human nuclear pre-60S ribosomal particle - State G'; 28S rRNA 8ine 5 120 3.2 RF00001 URS000002B0D5_9606 37491604 0003735 0005840 9606 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. human nuclear pre-60S ribosomal particle - State G'; 5S rRNA 8ine 8 155 3.2 RF00002,RF02540 URS00004B2C76_9606 37491604 0003735 0005840 9606 cgacucuuagcggnggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<.<<.....>>>.....(.<<<......>>.............>>>..)...>>>....<<...>><<<<<<<<<.....>>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((...))(((((((((.....))))))))).................... human nuclear pre-60S ribosomal particle - State G'; 5.8S rRNA 8inf 2 3654 3.0 RF02543 URS000268145C_9606 37491604 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugagnccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaanggaaaguugaaaagaacuuugaagngagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcggcccggcggaucuuucccgcgcgggggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcunggaaggcccggcggggaagguggcucgggggcccccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcncucuccccccucccggcgcgccggggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccgggggaggccacgcgcgcgucccccgaagagggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccnucuugnaacncggaccaaggagucuaacacgngcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgagggngcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuagnacccnanagauggugancuaugccugggcagggcgaagccagaggaaacucuggugnagguccguagcgguccugacgugcaaaucgnucguccgaccuggguauagnggcgaaagacuaaucgaaccaucuaguagcuggnucccuccgaaguuucccucaggauagcuggcgcucucgcagacccgacgcccgccacgcaguuuuauccgguaaagccuuuaaaungguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacnuuuggnaagcngaacuggcgcuncgggaugaaccgaacgccggguuaangcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggaugncgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagcggcggcccggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcgnugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguagunnnaaauauucaaacganaacuuugaaggccgaaguggngaaggguuccaugugaacagnanuugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccugcccuccgaucgaaagggagucgnguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccggggnagaggguguaaaucucgcnccgggccguaccnauauccgcagcaggucuncaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagcnggauccguaacuucgggauaaggauuggcucuaagggcugggucggucgcggccggcgccuagcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugccnagugcucugaaugucanagugnagaaauucaaugaagcgcggguaaacggcgggaguacucucuuaagaacgagauucccacugucccuaccuacuauccagcgaaaccacngncaagggaacgngcuuggnggaaucagcngngaaagaagacccuguugagcuugacucuagucuggcacggugaagagacaugagagguguagaauaagugggaggcccccggcgcccccccgguguccccgcgaggggcccggggcgggguccgccggcccugcgggccgccggugaaauaccacuacucugaucguuuuuucacugacccggngaggcgggggggcgagccccgaggggcucucgcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccaggugggnaguuugacuggggcgguacaccugucaaacgguancgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucungauuuucagnacgaauacagaccgugaaagcggggccunacgauccuucugaccuuuungguuuuaagcaggannugucagaaaaguuaccacagggauauuguggcggccaagcguucauagcgacgucgcuuuuugcuucgaugucggcucuuccuaucauugunaagcagaauunaccaagcguungauuguucacccacuaauagggaacgugngcuggnnuuagancgucgugagacagnuuaguuuuacccuncugaugnuguguuguugccaugguaauccugcncaguacgagaggaaccgcagguncanacauuugguguaunugcuuggcugaggagccaauggggcgaagcuacnaucugugggauuaugacunaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccggucccccgccgggguccgguncngagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>>..<<<<<<<<<<...<<.<<<<<........<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>...>>>>>.>>..>>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<......>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<<<..<<<<<<<.......<<....<<<<.<<<..<<.<..>.>>>>>>>>>>>......>>>>...>>>>>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<.<<<<<<<<<<<<<<<...<<..<<<....<<<<......<<<<<<<<..>>>>>>>>.......>>>>...>>>........>>>>>>..>>>>>>>>>>>....................<<<<<..<<<<<<<............>>>>>>>.<<<<<<.<<<<.<<<<<<<<<<.<<<<<..<<<<<.<..<......>.>..>>>>>..>>>>.>.>>>>>>>.>>>...>>>>..>>>>.>>..<<<<<<<<<.......>>>>>>>.>>.....>>>>>......>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>>.<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<......>>>>>>>..<<<<<...<<<..<<<..[[....(((>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<......................<<<.<<<<<<<<....<<<..>>>....>>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>>>>>>.>>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<........<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>....>>>>>>>>>>>>..{.......))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<..........)))....]]............................>>>>>>>>>....>>>>>>.<<<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>.>>.....>>>>>.<<<....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<....<<.....>>..>>>>>....((<<<<<<...<<....<<<....>>>.............<<<<........>>>>.....>>....>>>..<<<<<........>>>>>))<<<<....<<<<<...<<<<<<<....>>>>>>>...<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<<<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>.>.>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<...............<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<.......................>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>.......<<<..<<<<<<....<<<....<<<<<....>>>>.>...>>>.>>>>..>>>>><<<.<...>.>>>......>>.>>>>>>>.....>>.>>>>>>>..>>>>>>...>>>....<<<<<........>>>>>....<<<<<..<<<........<<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<<.<<<...............................................................................................................>>.>.>>>>>>>>...<<<<<.....<<<<........<<....>>.....................<<<<<<<<<<.......>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>.<<<<<<<...........>>>>>>>.<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))].....<<<<<<<..<<<..)))))).>>>>>>>>>>.........>>>>..>>>>>>>....}..<<<<<<...<<.......>>...>>>>>>.........((...<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.....))..>>>.....>>>>>..>...>>>>......<<<<<<<....>>>.>>>>........>>>.>>>>>.....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<.]]]..>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.....<<<<<<..<<..<<<<....<<<........<<<<<.<<<<....>>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>..............>>>>..>>.>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<.<..<<<<<......>>>>>..>>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((...((((((((((.....)))))).)))).....)))....((((((((((...((.(.(((...(....((((((((..({((((......)))))....[[(...).(((....}]])))...).))))))))..))).).))..))))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....(((((((((((..(((((((.......((....((((.((....(.(..).)..))))))))......))))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((..(.((((......(.(((((....))))).).......)))).).)))........))))))..)))))))))))....................((((((.((((((..............)))))).((((((.(.((.(((((((((((.((((..(((......(......)......)))..)))).).))))))).)))...)).)..)))).))..((((((((.........)))))).))..[.)))))).....))).)))))...)))))...)))))))).<((((........))))(.((((..(.(((((((((((((..(((..((((..........)))..)..)))...((....))...(((((.(......).)))))..(((((...(((..(((..[......[[)))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))..).))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((.(((((((......................(((.((((((((....((....))....))))))...(((((((((.(......))))))))))....))))))))))))..))..((((..((((.....))))..))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((.(.....{.(((((.(.(...((.........))...).).....(...((......)).).)))))...).)))))))))))..........]]].)....))))))))))...)))))))((((((.(((..........]]......]]..............(...)........)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....)))).)((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...((....(((....))).........(...((((........)))))....))....))...(((((........)))))]]((((....(((((...((((((......))))))..((((....)))...(...((((((...(((((((((((((((((((((((..{{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....(((((((.......))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((...(.(.......))........)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].....(((..((((((.....((.....((((....)))).....))..))))..)))))(((.(...).)).).....)).))))))).)..))).)))))))..))))))....)).[...((((.....>].)))).....(((((..((((.......(((((.((((((..(((((.(((((((((.(((((((..(.............................................................................(.)....................................)..)))))))...(((((.....((((.....................................((((((((((.......))))))))))..))))..)))))....)))))))))..)))))...(((.....))).(((((((...........)))))))[((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(..((..((((....{..))))..)).)(((....))).))]]].......((((((..(((..]]]]]].))))))))).....}....))))..))))))).......((((((...((.......))...))))))..........[....(((.((((((..(.(.((((........))))...).).(((.....]...))).....)))))..)...))).......(((((((....))).))))..a..)..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}}.)))))..)).))...))))...)))).((((...((((.....}.......))))...))))..)))...).)))))).....((((((..((..((((.(..(((........(((((.((((....)))).))))).......)))...(((..(((.....((((.(((((((......)))))))))))....)))..)))...........)..))))..)).))))))(((((.(..(.......)..)....((.(((((((.((.....((((.(..(((((......)))))..)))))....))....)))).))).))..))))).. human nuclear pre-60S ribosomal particle - State F'; 28S rRNA 8inf 5 120 3.0 RF00001 URS000002B0D5_9606 37491604 0003735 0005840 9606 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. human nuclear pre-60S ribosomal particle - State F'; 5S rRNA 8inf 8 154 3.0 RF00002,RF02540 URS00004B2C76_9606 37491604 0003735 0005840 9606 gacucuuagcggnggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacugcggccccggguuccucccggggcuacgccugucugagcgucgcu ........................................<<<<<<.<<.....>>>.....(.<<<......>>.............>>>..)...>>>....<<...>><<<<<<<<<.....>>>>>>>>>.................... ........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((...))(((((((((.....))))))))).................... human nuclear pre-60S ribosomal particle - State F'; 5.8S rRNA 8ink 8 156 3.2 RF00002,RF02540 URS00004B2C76_9606 37491604 0003735 0005840 9606 cgacucuuagcggnggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<.<<.....>>>.....(.<<<......>>.............>>>..)...>>>....<<....>><<<<<<<<<.....>>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))(((((((((.....))))))))).................... human nuclear pre-60S ribosomal particle - State D; 5.8S rRNA 8ink 3 115 3.2 RF00001 URS000268145D_9606 37491604 0003735 0005840 9606 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggaccgccuggaauaccgggugcuguaggc <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<......<<.<<.<<<..>>>>>.>>....>>>>>>>>>>>>>>> (.(((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((..........(..((..)).)........))))))))))))).) human nuclear pre-60S ribosomal particle - State D; 5S rRNA 8ink 2 3495 3.2 RF02543 URS000268145C_9606 37491604 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugagnccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaanggaaaguugaaaagaacuuugaagngagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcggcccggcggaucuuucccgcgcgggggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcunggaaggcccggcggggaagguggcucgggggcccccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcncucuccccccucccggcgcgccggggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccgggggaggccacgcgcgcgucccccgaagagggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccnucuugaacncggaccaaggagucuaacacgngcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgagggngcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuagnacccnanagauggugancuaugccugggcagggcgaagccagaggaaacucuggugnagguccguagcgguccugacgugcaaaucgnucguccgaccuggguauagnggcgaaagacuaaucgaaccaucuaguagcuggnucccuccgaaguuucccucaggauagcuggcgcucucgcagacccgacgcccgccacgcaguuuuauccgguauggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcngaacuggcgcuncgggaugaaccgaacgccggguuaangcgcccgaugccgacgcucaucagacccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggaugncgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagcggcggcccggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcgnugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguagunnnaaauauucaaacganaacuuugaaggccgaaguggngaaggguuccaugugaacagnanuugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucgnguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccggggnagaggguguaaaucucgcnccgggccguaccnauauccgcagcaggucuncaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagcnggauccguaacuucgggauaaggauuggcucuaagggcugggucggucgcggccggcgccuagcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugccnagugcucugaaugucanagugnagaaauucaaugaagcgcggguaaacggcgggaguacucucuuaagancgagauucccacugucccuaccuacuauccagcgaaaccacngncaagggaacgngcuuggnggaaucagcngngaaagaaganccuguugagcuugacucuagucuggcacggugaaguuuuuucacugacccggngaggcgggggggcgagccccgaggggcucucgcuucuggcgccaancgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccaggugggnaguuuccugucgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuuuacgaauacagaccgugaaagcggggccgauccuucugaccuuuuggguuuuaagcaggagguaaguuaccacagggauaggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugunaagcagaauunaccaagcguungauuguucacccacuaauagggaacgugngcuggnnuuagancgucgugagacagnuuaguuuuacccuncugaugnuguguuguugccaugguaauccugcncaguacgagaggaaccgcagguncanacauuugguguaunugcuuggcugaggagccaauggggcgaagcuacnaucugugggauuaugacunaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccggucccccgccgggguccgguncngagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..[[[..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>>..<<<<<<<<<<...<<<<<<<<........<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>...>>>>>>>>..>>>>>>>>>>.......<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<......>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<<<..<<<<<<<....<..<<....<<<<.<<<..<<<<..>>>>>>>>>>>>>.>....>>>>...>>>>>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<<<<<<<<<<<<<<<<<...<<..<<<..<.<<<<......<<<<<<<<..>>>>>>>>.......>>>>.>.>>>........>>>>>>..>>>>>>>>>>>....................<<<<<..<<<<<<<............>>>>>>>.<<<<<<.<<<<.<<<<<<<<<<.<<<<<..<<<<<...<<......>>...>>>>>..>>>>.>.>>>>>>>.>>>...>>>>..>>>>.>>..<<<<<<<<<.......>>>>>>>.>>.....>>>>>.....>>>.>>>>>...>>>>>...>>>>>>>>..<<<<.......>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<..........>>>.....>>>...<<....>>...<<<<<<<......>>>>>>>..<<<<<...<<<..<<<..(((...(((>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<........>.><<<<<<<<<<......................<<<.<<<<<<<<<...>>>>>>>...<<<<<<<<<.........>>>>>>>>>....>>>>>>>>>>>>.>>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<.........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<..........)))...)))............................>>>>>>>>>....>>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<<....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<....<<.....>>..>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<...<<...>>...>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<...<<<<.<<....>>.>>>>...<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<<<<<<<<<<<<..{{{..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>.>.>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<..<............>.......>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>.......<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<.<...>.>>>......>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>...>>>....<<<<<........>>>>>....(((((..{{{........(((((.{{[[[[..<<<<<.<<<<<<<<<.<<<<<<...>>>>>>...<<<<<.....<<<<.....<<..<....>....>>................<.<<<<<<<<.......>>>>>>>>.>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<...>.>>..........<<<<<...<<<<<<.......>>>>>>...........((......>>>>>.....<<<..<<<<....>>>>..>>>.<<<....>>>...))....(((((...(((..>>>>>>.))).)))))...]]]]..}})))))..........<<<<<<.................>>>>>>.................<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>>......<<<<<<<....>>>.>>>>........}}}.))))).....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<.}}}..>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.....<<<<<<..<<..<<<<....<<<........<<<<<.<<<<....>>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>..............>>>>..>>.>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<.<..<<<<<......>>>>>..>>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((...((((((((((.....)))))).)))).....)))....((((((((((...((((((((........((((((((..({((((......)))))....[[(...).(((....}]])))...).)))))))...))))))))..))))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....(((((((((((..(((((((.......((....((((.((....(.(..).)..))))))))......))))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((..(.((((......(.((((((..)))))).).......)))).).)))........))))))..)))))))))))....................((((((.((((((..............)))))).((((((.((((.((((((((((..((.(..(((......(......)......)))..).))...))))))).)))...))))..)))).))..((((((((.........)))))).))..[.)))))).....))).)))))...)))))...))))))))..((((.......))))((((((....(((((((((((((..(((..((((..........)))..)..)))...((....))...(((((.(......).)))))..(((((...(((..(((..[......[[)))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(........).)((.(((((((......................(((.(((((((.......)))))...(((((((((.(......))))))))))....))))))))))))..))..((((....((.....))....))))....(((......)))...(((((((...((([[[.....(.(((((......(.........(((.((((((((((.....{.(((((.(.(...((.........))...).).....(...((......)).).)))))...)))))))))))))..........]]].)....)))))).)))...)))))))((((((.(((..........]]......]]..............(...)........)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...((....(((....)))..........((.((((...((....)..)))))))......))....))...(((((........)))))]]((((....(((((...((.(.((....)).).))..((((....)))...(...((((((...(((((((((((((((((((((((..{{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....(((((((.......))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((...(.(.......))........)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].....(((..((((((.(..(((.....((((....)))).....))))))))..)))))(((.(...).)).).....)).))))))).)..))).)))))))..))))))....)).[..(((((......].)))))....(((((..((((.......(((((.((((((..(((((.(((((((((.((((((...))))))...(((((.....((((.....((............))................(.((((((((.......)))))))).)..))))..)))))....)))))))))..)))))...((......)).......(..(((((.(.((((((.......))))))...).......[.[.....)))))..)..(((..((((....))))..))).(((....)))...]]....((((.(..(((..]]]]]].)))).))).)..))))..)))))))..........((((((.....(.......)...))))))..................(((.((((((..(.(.((((........))))...).).(((.(.....).))).....)))))..)...))).......(((((((....))).))))..a..)..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}}.)))))..)).))...))))...)))).((((...((((.....}.......))))...))))..)))...).)))))).....((((((..((..((((.(..(((........(((((.((((....)))).))))).......)))...(((..((((....((((.(((((((......)))))))))))...))))..)))...........)..))))..)).))))))(((((.(..(.......)..)....((.(((((((.((.....((((.(..(((((......)))))..)))))....))....)))).))).))..))))).. human nuclear pre-60S ribosomal particle - State D; 28S rRNA 8ip8 aa 1695 2.9 RF01960,RF02542,RF01959,RF00177 38267667 0003735 0005840 4565 uaccugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugugcaaguaugaaccaauuugaacugugaaacugcgaauggcucauuaaaucaguuauaguuuguuugaugguacgugcuacucggauaaccguaguaauucuagagcuaauacgugcaacaaaccccgacuucugggaggggcgcauuuauuagauaaauccgaugauucaugauaacucgacggaucgcacggccuucgugccggcgacgcaucauucaaauuucugcccuaucaacuuucgaugguaggauaggggccuaccaugguggugacgggugacggagaauuaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccugacacggggagguagugacaauaaauaacaauaccgggcgcauuagugucugguaauuggaaugaguacaaucuaaaucccuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuuaaguuguugcaguuaaaaagcucguaguuggaccuugggccggccggcaucgcgcuccuagcccggcaucguuacuuugaagaaauuagagugcucaaagcaagccaucgcucuggauacauuagcaugggauaacaucauaggauuccgguccuauuguguuggccuucgggaucggaguaaugauuaauagggacagucgggggcauucguauuucauagucagaggugaaauucuuggauuuaugaaagacgaacaacugcgaaagcauuugccaaggauguuuucauuaaucaagaacgaaaguugggggcucgaagacgaucagauaccguccuagucucaaccauaaacgaugccgaccagggaucggcggauguugcuuauaggacuccgccggcaccuuaugagaaaucaaagucuuuggguuccggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggcguggagccugcgcuuaauuugacucaacacggggaaacuuaccagguccagacauagcaaggauugacagacugagagcucuuucuugauucuaugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccguuaacgaacgagaccucagccugcuaacuagcuaugcggagccaucccuccgcagcuagcuucuuagagggacuauggccguuuaggccacggaaguuugaggcaauaacaggucugucaugcccuuagauguucugggccgcacgcgcgcuacacugauguauucaacgaguauauagccuuggccgacaggcccggguaaucuugggaaauuucaucgugauggggauagaucauugcaauuguuggucuucaacgaggaaugccuaguaagcgcgagucaucagcucgcguugacuacgucccugcccuuuguacacaccgcccgucgcuccuaccgauugaaugguccggugaaguguucggaucgcggcgacggacgucgcgagaaguccauugaaccuuaucauuuagaggaagcagaagucguaacaagguuuccguaggugaaccugcggaaggaucauug ...<<<<<.[.((((>>>>>.<<<.<<<<<<...<.<...<......<<<.<<<..<<....<<....<<...........>>...>>.>>......<<........<<<..<<..<<....<<<<<............<<.....<..<<<.....>>>..>......>>..........<<<..<<....>>..>>>.<...<<<<<<..................>>>>>>.....>...<<<<..<<<......>>>.>>>>..>>>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>...<<....>>.....>>>>>>.........<<<....<<<.....>>>..>>>..>....>.>.....<<<<<.<.................>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>..........<.<((.....<.<<...<<<.<.....<.<<<<..>>>>.>....................<<<<<<.<<.......<<...<.......>...<.......>.....>>......>>.>>..>>>>........<<..<<<<<<<...............>>>>>>>..>>......>....<<<<<<.<<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<.<.....>>>>>>>>>>>>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<.......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<...<<<<<<<......>>>>>>>.....>>..>>>>.>>.....<<<<<.....>>>>>........>>>>>....>>>.>>>.....>>>>>>>.....>.>>>>>......>>>>.>>>.....<<<<.<.......<<.......<<<.<<<<....>>>>.>>>....>>........>.>>>>......<....<<<<<<..........>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<.<<.<<....<<<<<<<..<<<..<<<<..<...<<<...<.......>...>>>...>..>>>>..>>>..>>>>>>>...>>.>>.>>..>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..)))).(((.((((((...(.(...((.....(((.(((..((....((....((...........))...))[))......(((.......(((..((..((....(((((.............(.....(..(((.....)))..)......)...........(((..((....))..))).(((.((((((.....{...(......).)))))).).).).(.((((..(((......))).))))).)))))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.(((......)))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)....).).....((....(.(...........)...)....))......(.(.(...........))..).........((((([[....(.((((.....((..]])).......))))))))))..)))))))))...[......(.([[...(.(.((...(((..(......((.(..).))......................((((((.((.......((..((.......))................))......)).))..))))....(.).((..(....(..............}..).....).)).....)....(((.(((..(...((((..((..(((((((....((........)).......)))))))..)).......((....))...))))..)..)))..))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..((((((((.....(.....)...))))))))..)))...((..]]))...))...].))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((.(.....((........))..........(((((.(....(((((.....(..((..((........))..))....).)))))...((.(((...(.((((((....((..(((((....)))..(.((......)))...))..))....(((((.((..((((..((...(((((((......))))))).....))..)))).))..(..(((((.....))))).....)..)))))....))).))).....).))))).....).)))))...)..)))).))).(...((((.(.......((.......(((.((((....)))).)))....))........).))))......(....((((((..........))))))....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(.((.((.((..(.(((((((..(((..((((..(...(((...((.....))...)))...)..))))..)))..))))))))..)).)).))..).))...)..)..(((((((((....)))))))))}........ Wheat 80S ribosome stalled on AUG-Stop boron dependently; 18S ribosomal RNA 8ip8 RB 3147 2.9 RF02543 38267667 0003735 0005840 4565 gcgcgaccccaggucaggcgggacuaccgcugaguuuaagcauauaaauaagcggaggagaagaaacuuacaaggauuccccuaguaacggcgagcgaaccgggagcagcccagcuugagaaucgggcggcugugccguccgaauuguagucuggagaggcguccucagcgacggaccgggcccaaguccccuggaaaggggcgccugggagggugagagccccguccggcccggacccugucgccccacgaggcgccgucaacgagucggguuguuugggaaugcagcccaaaucgggcgguagacuccguccaaggcuaaauacaggcgagagaccgauagcgaacaaguaccgcgagggaaagaugaaaaggacuuugaaaagagagucaaagagugcuugaaauugccgggagggaagcggaugggggccggcgaugcgccccggcgcucggggcguggacuguugucggccgcgccggcggccaaagcccgggggcuccgcgcccccggcagccgucgucggcacggccgguacccgcgcgccgaaaggcgugccccucggggcacugcgcugcaacgcccugcgggcucuccauccgacccgucuugaaacacggaccaaggagucugacaugcgugcgagucgacggguucugaaaccugggaugcgcaaggaagcugacgagcgggaggcccucacgggccgcaccgcuggccgacccugaucuucugugaaggguucgaguuggagcacgccugucgggacccgaaagauggugaacuaugccugagcggggcgaagccagaggaaacucugguggaggcucgaagcgauacugacgugcaaaucguucgucugacuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggagcccauuacgaguucuaucagguaaagccaaugauuagaggcauuggggacgcaacguccucgaccuauucucaaacuuuaaauagguaggauggcgcggcugcuucggugagccgugccauggaaucgggugcuccaagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccggaagccggguuacggugcccaacugcgcgcuaaccuagaacccacaaaggguguuggucgauuaagacagcaggacgguggucauggaagucgaaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagccccgaaaauggauggcgcugaagcgcgcgacccacacccggccaucugggcgagugccaugccccgaugaguaggagggcgcggcggccgaugcaaaacccggggcgcgagcccgggcggagcggccgucggugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaaggccgaagaggagaaagguuccaugugaacggcacuugcacauggguaagccgauccuaagggaagggguaaccccggcagauagcgcgaucacgcgcauccccgaaagggaaucggguuaagauuucccgagccgggauguggcgguugacggcgacguuaggaaguccggagacgccggcgggggccucgggaagaguuaucuuuucugcuuaacggccugccaacccuggaaacgguucagccggagguaggguccaguggccggaagagcacacgucgcgcgguguccggugcgcccccggcggcccaugaaaauccggaggaccgaguaccguucacgcccggucguacucauaaccgcaucaggucuccaaggugaacagccucuggccaauggaacaauguaggcaagggaagucggcaaaacggauccguaacuucgggaaaaggauuggcucugaggacugacagucgacucagaacugguacggacaaggggaauccgacuguuuaauuaaaacaaagcauugcgaugguccucgcggaugcugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaaugaauuaacgagauucccacugucccugucuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuaguccgacuuugugaaaugaauuuuacuuauuccgugggucggaagcggggcaugccccuccuuuuggcuccaaggcccggucuuaccgggccgauccgggcggaagacauugucagguggggaguuuggcuggggcggccaaucuguuaaaagauaacgcagguguccuaagaugagcucaacgagaacagaaaucucguguggaacaaaaggguaaaagcucguuugauucugauuuccaguacgaauacgaaccgugaaagcguggccuaucgauccuuuagaucuucggaguuugaagcuagaggugucagaaaaguuaccacagggauuacuggcuuguggcagccaagcguucauagcgacguugcuuuuugauccuucgaugucggcucuuccuaucauugcgaagcagaauucaccaaguguuggauuguucacccaccaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugacagugucgcgauaguaauucaaccuaguacgagaggaaccguugauucacacaauuggucaucgcgcuugguugaaaagccaguggcgcgaagcuaccgugugccggauuaugacugaacgccucuaagucagaauccaagcuagcaugcgacgccugcgcccgccgcccgccccgacccacguuaggggcgcuugcgcccccaagggcccgugccauuggcuaagccgguccggccgaagugccgcggucggccgccucgaagcucccuucccaacgggcggugggcugaauccuuugcagacgacuuaaauacgcgacggggcauuguaaguggcagaguggccuugcugccacgauccacugagauccaguccccgggucgcacggauucgu ..........................<<<<<.....<......>......>>>>>...........<<....>>..<<<<<.......<.....>......>>>>>..[[[...........<<<<<<<<<...>>>>>>>>>.............<<<<<<.<<<<.<<<<<<<.<<<<<<<.....<<<<......>>>>.((......<<<.....))>>>....>>>>>>>...>>>>>>>.....>>>>>>>>.>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<<<<<......<<<<<<<<<...>>>>>>>>>.<..<<<<<<<<<<<<.<<<<<<<<<......<<<<<<<.......>>>>>>>.....>>>>>>>>>.>>>>>>>.....<<<<<<<....>>>.<<<<<<..>>>>>>..>>>>..>>>>>..>....>>>.>>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<....<<<<<....>>>>>.....>>...<<....>>....<<<<<..<<<<<....>>>>>...>>>>><<<<<<<<.....<....>.....>>.>>>.>>>...>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<....<<<.<<<<<<<.....<<<....<<<....<<<.....<<<<<.....>>>>>...>>>....>>>..>.>>.....>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>.>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.......<..........<<<.<<<<<<.<<........<<<...<<.....<.........>.....>>........................>>>....>>.>>>>>>>>>..........))).>....>>>>>>.>>>...>>>>>>><<<<.<<<<.........>>>>.>>>>....>>>>>><.<<<<<<<<<........<<<.<<<<....>>>>>>>.....>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<...<<<....>>>.........<<<<....>>>>....>>>....>>...<<<<<.........>>>>>))<<<<.<<<<<<<<...<<<....>>>...<...<<<<<<...<<<<.<<<<<<<.<<<<<.<<<<.......>>>>.><...<<<<<.....<<<<<<....<<<<...>>>>....>>>>>>.....>>>>>....><<<<..........>>>>>>>>...>>>>>>>.>>>>.........>>>>>>...>......>>>>.>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<.<<<<<<<<<<<.>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<....>>>>......>>>>>>>...<<<.<<<..<<<<<<.....<<.....<<<<....>>>>.....>>..>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<.<<<...<<<<<<<..>>>>>>>...<<<<<.....<<<<...<<<<....>>>>...............<<<<<<.......>>>>>>..>>>>..>>>>>......>>>.>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<<<.<.<<<......>>>.>...>>>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<..<<<<...<<<<<.................>>>>>..<<<<<...<<<<....<<<<<<<<<......>>>>..>>>>>...>>>>..>>>>>..<<<...<<<<<...........>>>>>...>>>..>>>>....>>>>>>>....<<<<<<<<<<<<......<<.......<<<<<<<..>>>>>>>....>>...........<<<...<<<<<<<<<<<......>>>>.>>>>>>>.>>>..................>>>>>>>>>>>>.<<<<<<<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>...>>>>>..>>>>>>.. ..........................((((......(...[..).......))))...........((....))...((((.......(.]...)......))))...((((.........((((((((((...)))))))))....)........((((((.((((.(((((((.(((((((...({((((......)))))[[(...).(((....}]])))....)))))))...))))))).....)))))))).))...)....(((((((........))))))).....(((((..[.[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((((.((((..(....(.(.(((.....))).).)..(..((((((((((((.(((((((((......(((((((.......))))))).....))))))))).))))))).....(((((((....))).(((((....)))))..))))..)))))..)...)))).).))))))).[((((........))))((((((....((((((.((((((..((....(((........))).....))...((....))....(((((..(((((....)))))...)))))((((((((.....(....).....)).))).)))...)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((........)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((....(((.(((((((.....(((....(((..(.(((....((((((.....))))))..))).)..)))..)).).....)))))...(((((((((.(......))))))))))....))))))).)))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((.......(..........(((.((((((.(((.....{.(((.(...(...................).........................))))...))).)))))))))..........]]].)....))))))))))...)))))))((((.((((.........)))).))))....))))))(.(((((((((........(((.((((....))))))).....)))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...((((((...((.....)).))))))....[[(((.((...(((..((((....)))..)......((((....))))....)))....))...(((((.........)))))]]((((..(((((((..((((....)))...(..<((((((...((((.((((((((.((((.((((...{{..)))).)(...((((((....(((((.....(((.....))).....)))))...).)))))....)((((..........)))))))..).))))))).))))(...)....))))))...)).....)))).))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((.)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((....))))......))))))).}.(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.(.(.(((...(((((((..)))))))...(((((.....((((.(.(((......))).).........>...(((((.........)))))..))))..)))))......))).).)..)))))...((......[))..(.((((..........])))).)([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....((((((..((((.]]]].]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(((.(.(((......))).)...))).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))....))..))).)))))....(((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..)))))..(((...((((.....}.......))))...)))..))))....)))))))....(((((((((((.....(.((.......(((((((..)))))))....)))..........(((...(((((.((((((...).)))).).))))).)))...................))))))))))).(((((((..(.......)..).....((((((((..(((....((((.(..(((((......)))))..)))))...))).....)))...)))))..)))))).. Wheat 80S ribosome stalled on AUG-Stop boron dependently; 60S ribosomal RNA 8ip8 SB 160 2.9 RF00002 URS000080DD3B_4565 38267667 0003735 0005840 4565 cgacucucggcaacggauaucucggcucucgcaucgaugaagaacguagcgaaaugcgauaccuggugugaauugcagaaucccgugaaccaucgagucuuugaacgcaaguugcgcccgaggccauccggccgagggcacgccugccugggcgucacgc .........................................<<<<<<.((.....>>>....<<<<<<<.....))............>.>>>>.>>..>>>....<<.....>><<<<..<<<<....>>>>..>>>>..................... .........................................((((((.[[.....))).....((((((.....]]............).)))).)...)))....((.....))((((..((((....))))..))))..................... Wheat 80S ribosome stalled on AUG-Stop boron dependently; 5.8S ribosomal RNA 8ip8 TB 120 2.9 RF00001 URS0000188192_4565 38267667 0003735 0005840 4565 ggaugcgaucauaccagcacuaaggcaucggaucccgucagaacuccgaaguuaagcgugcuugggcgagaguaguacaaggaugggugaccucuugggaaguccucguguugcauuccc <<<<<<<<<....<<<<<<<......<<<<<..............>>>..>>.....>>>>>.>><<<<<.<.....<.<<<<.<<....>>>>>>.>....>.>>>>>>>>>>>>>>.. (((((((((....(((((((......((((((...(....)...))))..)).....))))).))(((((.......(.(.((.((....)))).).)......)))))))))))))).. Wheat 80S ribosome stalled on AUG-Stop boron dependently; 5S ribosomal RNA 8ip8 cl 75 2.9 38267667 4565 aucagagunncgcagcggaagcgungugggcccaunacccacagnnnncaggaucgnaaccuggcucugauacca <<<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((....[..)))).(.(((.......))).).....(((((..]....)))))))))))).... Wheat 80S ribosome stalled on AUG-Stop boron dependently; tRNAi 8ip9 aa 1695 3.0 RF01960,RF02542,RF01959,RF00177 38267667 0003735 0005840 4565 uaccugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugugcaaguaugaaccaauuugaacugugaaacugcgaauggcucauuaaaucaguuauaguuuguuugaugguacgugcuacucggauaaccguaguaauucuagagcuaauacgugcaacaaaccccgacuucugggaggggcgcauuuauuagauaaauccgaugauucaugauaacucgacggaucgcacggccuucgugccggcgacgcaucauucaaauuucugcccuaucaacuuucgaugguaggauaggggccuaccaugguggugacgggugacggagaauuaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccugacacggggagguagugacaauaaauaacaauaccgggcgcauuagugucugguaauuggaaugaguacaaucuaaaucccuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuuaaguuguugcaguuaaaaagcucguaguuggaccuugggccggccggcaucgcgcuccuagcccggcaucguuacuuugaagaaauuagagugcucaaagcaagccaucgcucuggauacauuagcaugggauaacaucauaggauuccgguccuauuguguuggccuucgggaucggaguaaugauuaauagggacagucgggggcauucguauuucauagucagaggugaaauucuuggauuuaugaaagacgaacaacugcgaaagcauuugccaaggauguuuucauuaaucaagaacgaaaguugggggcucgaagacgaucagauaccguccuagucucaaccauaaacgaugccgaccagggaucggcggauguugcuuauaggacuccgccggcaccuuaugagaaaucaaagucuuuggguuccggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggcguggagccugcgcuuaauuugacucaacacggggaaacuuaccagguccagacauagcaaggauugacagacugagagcucuuucuugauucuaugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccguuaacgaacgagaccucagccugcuaacuagcuaugcggagccaucccuccgcagcuagcuucuuagagggacuauggccguuuaggccacggaaguuugaggcaauaacaggucugucaugcccuuagauguucugggccgcacgcgcgcuacacugauguauucaacgaguauauagccuuggccgacaggcccggguaaucuugggaaauuucaucgugauggggauagaucauugcaauuguuggucuucaacgaggaaugccuaguaagcgcgagucaucagcucgcguugacuacgucccugcccuuuguacacaccgcccgucgcuccuaccgauugaaugguccggugaaguguucggaucgcggcgacggacgucgcgagaaguccauugaaccuuaucauuuagaggaagcagaagucguaacaagguuuccguaggugaaccugcggaaggaucauug ...<<<<<.[.((((>>>>>.<<<.<<<<<<...<.<...<......<<<.<<<..<<....<<....<<...........>>...>>.>>......<<........<<<..<<..<<....<<<<<............<<.....<..<<<.....>>>..>......>>..........<<<..<<....>>..>>>.<...<<<<<<..................>>>>>>.....>...<<<<.<<<<......>>>>>>>>..>>>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>..>>>..>....>.>.....<<<...<.................>...>>>......<<..<...........>..>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>>>>..........<.<((.....<.<<...<<<.<.....<.<<<<..>>>>.>....................<<<<<<.<<.......<<...<.......>...<.......>.....>>......>>.>>..>>>>........<...<<<<<<<...............>>>>>>>...>......>....<<<<<<.<<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<.<.....>>>>>>>>>>>>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<.......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<...<<<<<<<......>>>>>>>.....>>..>>>>.>>.....<<<<<.....>>>>>........>>>>>....>>>.>>>.....>>>>>>>.....>.>>>>>......>>>>.>>>.....<<<<.<.......<<.......<<<.<<<<....>>>>.>>>....>>........>.>>>>......<....<<<<<<..........>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<.<<.<<....<<<<<<<..<<<..<<<<..<...<<<..<<.......>>..>>>...>..>>>>..>>>..>>>>>>>...>>.>>.>>..>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..)))).(((.((((((...(.(...((.....(((.(((..((....((....((...........))...))[))......(((.......(((..((..((....(((((.............(.....(...((.....))...)......)............((..((....))..).).(((.((((((.....{...(......).)))))).).).).(.((((..(((......))).))))).)))))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)....).).....((.(..(((...........).).).)..))......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..)))))))))...[......(.([[...(.(.((...(((..(......((.(..).))......................((((((.((.......((..((.......))................))......)).))..))))........(...(....(..............}..).....)..).....)....(((.(((.((...((((..((..(((((((....((........)).......)))))))..)).......((....))...))))..)).)))..))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..((((((((.(((.(.....))))))))))))..)))...((..]]))...))...].))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((.(.....((........))..........(((((.(....(((((.....(..(..(((........)))..)....).)))))...((.(((...(.((((((....((..(((((....)))..(.((......)))...))..))....(((((.((..((((..((...(((((((......))))))).....))..)))).))..(..(((((.....))))).....)..)))))....))).))).....).))))).....).)))))...)..)))).))).(...((((.(.......((.......(((.((((....)))).)))....))........).))))......(....((((((..........))))))....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(.((.((.((..(.(((((((..(((..((((..(...(((...(.......)...)))...)..))))..)))..))))))))..)).)).))..).))...)..)..(((((((((....)))))))))}........ Wheat 40S ribosome in complex with a tRNAi; 18S ribosomal RNA 8ip9 cl 75 3.0 38267667 4565 aucagagunncgcagcggaagcgungugggcccaunacccacagnnnncaggaucgnaaccuggcucugauacca <<<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((....[..)))).(.(((.......))).)......((((..]....)))).))))))).... Wheat 40S ribosome in complex with a tRNAi; tRNAi 8ipa aa 1695 3.4 RF01960,RF02542,RF01959,RF00177 38267667 0003735 0005840 4565 uaccugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugugcaaguaugaaccaauuugaacugugaaacugcgaauggcucauuaaaucaguuauaguuuguuugaugguacgugcuacucggauaaccguaguaauucuagagcuaauacgugcaacaaaccccgacuucugggaggggcgcauuuauuagauaaauccgaugauucaugauaacucgacggaucgcacggccuucgugccggcgacgcaucauucaaauuucugcccuaucaacuuucgaugguaggauaggggccuaccaugguggugacgggugacggagaauuaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccugacacggggagguagugacaauaaauaacaauaccgggcgcauuagugucugguaauuggaaugaguacaaucuaaaucccuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuuaaguuguugcaguuaaaaagcucguaguuggaccuugggccggccggcaucgcgcuccuagcccggcaucguuacuuugaagaaauuagagugcucaaagcaagccaucgcucuggauacauuagcaugggauaacaucauaggauuccgguccuauuguguuggccuucgggaucggaguaaugauuaauagggacagucgggggcauucguauuucauagucagaggugaaauucuuggauuuaugaaagacgaacaacugcgaaagcauuugccaaggauguuuucauuaaucaagaacgaaaguugggggcucgaagacgaucagauaccguccuagucucaaccauaaacgaugccgaccagggaucggcggauguugcuuauaggacuccgccggcaccuuaugagaaaucaaagucuuuggguuccggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggcguggagccugcgcuuaauuugacucaacacggggaaacuuaccagguccagacauagcaaggauugacagacugagagcucuuucuugauucuaugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccguuaacgaacgagaccucagccugcuaacuagcuaugcggagccaucccuccgcagcuagcuucuuagagggacuauggccguuuaggccacggaaguuugaggcaauaacaggucugucaugcccuuagauguucugggccgcacgcgcgcuacacugauguauucaacgaguauauagccuuggccgacaggcccggguaaucuugggaaauuucaucgugauggggauagaucauugcaauuguuggucuucaacgaggaaugccuaguaagcgcgagucaucagcucgcguugacuacgucccugcccuuuguacacaccgcccgucgcuccuaccgauugaaugguccggugaaguguucggaucgcggcgacggacgucgcgagaaguccauugaaccuuaucauuuagaggaagcagaagucguaacaagguuuccguaggugaaccugcggaaggaucauug ...<<<<<.[.((((>>>>>.<<<.<<<<<<...<.<..........<<<.<<<..<<....<<....<<...........>>...>>.>>......<<........<<<..<<..<<....<<<<<..............<....<..<<<.....>>>..>......>...........<<<..<<....>>..>>>.<...<<<<<<..................>>>>>>.....>...<<<<..<<<......>>>.>>>>..>>>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>..>>>.......>.>.....<<<<<.<<..............>>.>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>..........<.<((.....<.<<...<<<.<.....<.<<<<..>>>>.>....................<<<<<<.<<.......<<...<.......>...<.......>.....>>......>>.>>..>>>>........<<..<<<<<<<...............>>>>>>>..>>......>....<<<<<<.<<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<.<.....>>>>>>>>>>>>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<.......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<...<<<<<<<......>>>>>>>.....>>..>>>>.>>.....<<<<<.....>>>>>........>>>>>....>>>.>>>.....>>>>>>>.....>.>>>>>......>>>>.>>>.....<<<<.<.......<<.......<<<.<<<<....>>>>.>>>....>>........>.>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<.<<.<<....<<<<<<<..<<<..<<<<..<...<<<...<.......>...>>>...>..>>>>..>>>..>>>>>>>...>>.>>.>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..)))).(((.((((((...(.(...((.....(((.(((..((....((....((...........))...))[))......(((.......(((..((..((....(((((.............(.....(..(((.....)))..)......)...........(((..((....))..))).(((.((((((.....{...(......).)))))).).).).(.((((..(((......))).))))).)))))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)....).).....((.(..(.................).)..))......(.(.(...........))..).........((((([[....(.((((.....((..]])).......))))))))))..)))))))))...[......(.([[...(.(.((...(((..(......((.(..).))......................((((((.((.......(...((.......)).................)......)).))..))))........((..(.((................}....))..).)).....)....(((.(((.((...((((..((..(((((((....((........)).......)))))))..)).......((....))...))))..)).)))..))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..((((((((.(((.(.....))))))))))))..)))...((..]]))...))...].))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((.......((........))........(.((((..(....(((((.....(..((.(((........))).))....).)))))...((.(((...(..(((((....((..(((((....)))..(.((......)))...))..))....(((((.((..((((..((...(((((((......))))))).....))..)))).))..(..(((((.....))))).....)..)))))....))).))......).))))).....)..))))).....)))).))).(...((((.(.......((.......(((.((((....)))).)))....))........).))))......(....((((((..........))))))....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(.((.((.((..(.(((((((..(((..((((..(...(((...((.....))...)))...)..))))..)))..))))))))..)).)).))..).))...)..)..(((((((((....)))))))))}........ Wheat 80S ribosome stalled on AUG-Stop boron dependently with cycloheximide; 18S ribosomal RNA 8ipa RB 3147 3.4 RF02543 38267667 0003735 0005840 4565 gcgcgaccccaggucaggcgggacuaccgcugaguuuaagcauauaaauaagcggaggagaagaaacuuacaaggauuccccuaguaacggcgagcgaaccgggagcagcccagcuugagaaucgggcggcugugccguccgaauuguagucuggagaggcguccucagcgacggaccgggcccaaguccccuggaaaggggcgccugggagggugagagccccguccggcccggacccugucgccccacgaggcgccgucaacgagucggguuguuugggaaugcagcccaaaucgggcgguagacuccguccaaggcuaaauacaggcgagagaccgauagcgaacaaguaccgcgagggaaagaugaaaaggacuuugaaaagagagucaaagagugcuugaaauugccgggagggaagcggaugggggccggcgaugcgccccggcgcucggggcguggacuguugucggccgcgccggcggccaaagcccgggggcuccgcgcccccggcagccgucgucggcacggccgguacccgcgcgccgaaaggcgugccccucggggcacugcgcugcaacgcccugcgggcucuccauccgacccgucuugaaacacggaccaaggagucugacaugcgugcgagucgacggguucugaaaccugggaugcgcaaggaagcugacgagcgggaggcccucacgggccgcaccgcuggccgacccugaucuucugugaaggguucgaguuggagcacgccugucgggacccgaaagauggugaacuaugccugagcggggcgaagccagaggaaacucugguggaggcucgaagcgauacugacgugcaaaucguucgucugacuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggagcccauuacgaguucuaucagguaaagccaaugauuagaggcauuggggacgcaacguccucgaccuauucucaaacuuuaaauagguaggauggcgcggcugcuucggugagccgugccauggaaucgggugcuccaagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccggaagccggguuacggugcccaacugcgcgcuaaccuagaacccacaaaggguguuggucgauuaagacagcaggacgguggucauggaagucgaaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagccccgaaaauggauggcgcugaagcgcgcgacccacacccggccaucugggcgagugccaugccccgaugaguaggagggcgcggcggccgaugcaaaacccggggcgcgagcccgggcggagcggccgucggugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaaggccgaagaggagaaagguuccaugugaacggcacuugcacauggguaagccgauccuaagggaagggguaaccccggcagauagcgcgaucacgcgcauccccgaaagggaaucggguuaagauuucccgagccgggauguggcgguugacggcgacguuaggaaguccggagacgccggcgggggccucgggaagaguuaucuuuucugcuuaacggccugccaacccuggaaacgguucagccggagguaggguccaguggccggaagagcacacgucgcgcgguguccggugcgcccccggcggcccaugaaaauccggaggaccgaguaccguucacgcccggucguacucauaaccgcaucaggucuccaaggugaacagccucuggccaauggaacaauguaggcaagggaagucggcaaaacggauccguaacuucgggaaaaggauuggcucugaggacugacagucgacucagaacugguacggacaaggggaauccgacuguuuaauuaaaacaaagcauugcgaugguccucgcggaugcugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaaugaauuaacgagauucccacugucccugucuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuaguccgacuuugugaaaugaauuuuacuuauuccgugggucggaagcggggcaugccccuccuuuuggcuccaaggcccggucuuaccgggccgauccgggcggaagacauugucagguggggaguuuggcuggggcggccaaucuguuaaaagauaacgcagguguccuaagaugagcucaacgagaacagaaaucucguguggaacaaaaggguaaaagcucguuugauucugauuuccaguacgaauacgaaccgugaaagcguggccuaucgauccuuuagaucuucggaguuugaagcuagaggugucagaaaaguuaccacagggauuacuggcuuguggcagccaagcguucauagcgacguugcuuuuugauccuucgaugucggcucuuccuaucauugcgaagcagaauucaccaaguguuggauuguucacccaccaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugacagugucgcgauaguaauucaaccuaguacgagaggaaccguugauucacacaauuggucaucgcgcuugguugaaaagccaguggcgcgaagcuaccgugugccggauuaugacugaacgccucuaagucagaauccaagcuagcaugcgacgccugcgcccgccgcccgccccgacccacguuaggggcgcuugcgcccccaagggcccgugccauuggcuaagccgguccggccgaagugccgcggucggccgccucgaagcucccuucccaacgggcggugggcugaauccuuugcagacgacuuaaauacgcgacggggcauuguaaguggcagaguggccuugcugccacgauccacugagauccaguccccgggucgcacggauucgu ..........................<<<<<.....<......>......>>>>>...........<<....>>..<<<<<.......<.....>......>>>>>..[[[....<......<<<<<<<<<...>>>>>>>>>......>......<<<<<<.<<<<.<<<<<<<.<<<<<<<.....<<<<......>>>>.((......<<<.....))>>>....>>>>>>>...>>>>>>>.....>>>>>>>>.>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<<<<<......<<<<<<<<<...>>>>>>>>>.<..<<<<<<<<<<<<.<<<<<<<<<......<<<<<<<.......>>>>>>>.....>>>>>>>>>.>>>>>>>.....<<<<<<<....>>>.<<<<<<..>>>>>>..>>>>..>>>>>..>....>>>.>>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<....<<<<<....>>>>>.....>>...<<....>>....<<<<<..<<<<<....>>>>>...>>>>><<<<<<<<.....<....>.....>>.>>>.>>>...>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<....<<<.<<<<<<<.....<<<....<<<..<.<<<.....<<<<.......>>>>...>>>.>..>>>..>.>>.....>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>.>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<......<<..........<<<.<<<<<<.<<<.......<<<...<<.....<.........>.....>>........................>>>...>>>.>>>>>>>>>..........))).>>...>>>>>>.>>>...>>>>>>><<<<.<<<<.........>>>>.>>>>....>>>>>>..<<<<<<<<<........<<<.<<<<....>>>>>>>.....>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<...<<<....>>>.........<<<<....>>>>....>>>....>>...<<<<<.........>>>>>))<<<<.<<<<<<<<...<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<.<<<<.......>>>>.><...<<<<<.....<<<<<<....<<<<...>>>>....>>>>>>.....>>>>>....><<<<..........>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>>.>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<.<<<<<<<<<<<.>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<....>>>>......>>>>>>>...<<<.<<<..<<<<<<.....<<.....<<<<....>>>>.....>>..>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<.<<<...<<<<<<<..>>>>>>>...<<<<<.....<<<<...<<<<....>>>>...............<<<<<<.......>>>>>>..>>>>..>>>>>......>>>.>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<<<.<.<<<......>>>.>...>>>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<..<<<<.<.<<<<<.................>>>>>.><<<<<...<<<<....<<<<<<<<<......>>>>..>>>>>...>>>>..>>>>>..<<<...<<<<<...........>>>>>...>>>..>>>>....>>>>>>>....<<<<<<<<<<<<......<<.......<<<<<<<..>>>>>>>....>>...........<<<...<<<<<<<<<<<......>>>>.>>>>>>>.>>>..................>>>>>>>>>>>>.<<<<<<<.............>.....<<<<<<<<<.<<<....<<<<.<..<<<<<......>>>>>..>>>>>...>>>....>>>>...>>>>>..>>>>>>.. ..........................((((......(...[..).......))))...........((....))...((((.......(.]...)......))))...((((.........((((((((((...)))))))))....)........((((((.((((.(((((((.(((((((...({((((......)))))[[(...).(((....}]])))....)))))))...))))))).....)))))))).))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((((.((((..(...((.(.(((.....))).).)).(..(((((.((((((.(((((((((......(((((((.......))))))).....))))))))).))))))......(((((((....))).(((((....)))))..))))..)))))..)...)))).).))))))).[((((........))))((((((....((((((.((((((..((....(((........))).....))...((....))....(((((..(((((....)))))...)))))((((((((.....(....).....)).))).)))...)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((........)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((....(((.(((((((.....(((....(((..(.(((....((((((.....))))))..))).)..)))..)).).....)))))...(((((((((.(......))))))))))....))))))).)))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((.......(..........(((.((((((.(((.....{.(((.(...(...................).........................))))...))).)))))))))..........]]].)....))))))))))...)))))))((((.((((.........)))).))))....))))))(((((((((((........(((.((((....))))))).....))))))))).)).....))))))((.....((.....((((((.......))))))((((.....((((..((...((((((...((.....)).))))))....[[(((.((...(((..((((....)))..)......((((....))))....)))....))...(((((.........)))))]]((((.((((((((..((((....)))...(..<((((((...((((.((((((((.((((.((((...{{..)))).)(...(((((.....(((((.....(((.....))).....))))).....)))))....)((((..(.....).)))))))..).))))))).))))(...)....))))))...)).....)))).)))))))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((.)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((....))))......))))))).}.(.(.(((..((.(((.(...((.....((((....)))).....)).))))...)))))(((((.........)))))........((..........(((((.......)))))..)..)....).)....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.(((.(((...(((((((..)))))))...(((((.....((((.(.(((......))).).........>...((((((.......))))))..))))..)))))......))).)))..)))))...((......[))..((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(((.(.(((......))).)...))).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))....))..))).)))))....(((((((..(((..(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..)))))..(((...((((.....}.......))))...)))...)))....)))))))....((((.((((((.....(.((.......(((((((..)))))))....)))..........(((...(((((.((((((...).)))).).))))).)))...................)))))).)))).(((((((..(.......)..).....(((((((((.(((....((((.(..(((((......)))))..)))))...)))....))))...)))))..)))))).. Wheat 80S ribosome stalled on AUG-Stop boron dependently with cycloheximide; 60S ribosomal RNA 8ipa SB 160 3.4 RF00002 URS000080DD3B_4565 38267667 0003735 0005840 4565 cgacucucggcaacggauaucucggcucucgcaucgaugaagaacguagcgaaaugcgauaccuggugugaauugcagaaucccgugaaccaucgagucuuugaacgcaaguugcgcccgaggccauccggccgagggcacgccugccugggcgucacgc .........................................<<<<<<.((.....>>>....<<<<<<<.....))............>.>>>>.>>..>>>....<<.....>><<<<..<<<<....>>>>..>>>>..................... .........................................((((((.[[.....))).....((((((.....]]............).)))).)...)))....((.....))((((..((((....))))..))))..................... Wheat 80S ribosome stalled on AUG-Stop boron dependently with cycloheximide; 5.8S ribosomal RNA 8ipa TB 120 3.4 RF00001 URS0000188192_4565 38267667 0003735 0005840 4565 ggaugcgaucauaccagcacuaaggcaucggaucccgucagaacuccgaaguuaagcgugcuugggcgagaguaguacaaggaugggugaccucuugggaaguccucguguugcauuccc <<<<<<<<<....<<<<<<<......<<<<<..............>>>..>>.....>>>>>.>><<<<<.<.....<.<<<<.<<....>>>>>>.>....>.>>>>>>>>>>>>>>.. (((((((((....(((((((......(.((((...(....)...))))...).....))))).))(((((.......(.((((.((....)))))).)......)))))))))))))).. Wheat 80S ribosome stalled on AUG-Stop boron dependently with cycloheximide; 5S ribosomal RNA 8ipa cl 75 3.4 38267667 4565 aucagagunncgcagcggaagcgungugggcccaunacccacagnnnncaggaucgnaaccuggcucugauacca <<<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((...(((....[..)))..(.(((.......))).).....(((((..]....)))))))))))).... Wheat 80S ribosome stalled on AUG-Stop boron dependently with cycloheximide; tRNAi 8ipb aa 1695 3.4 RF01960,RF02542,RF01959,RF00177 38267667 0003735 0005840 4565 uaccugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugugcaaguaugaaccaauuugaacugugaaacugcgaauggcucauuaaaucaguuauaguuuguuugaugguacgugcuacucggauaaccguaguaauucuagagcuaauacgugcaacaaaccccgacuucugggaggggcgcauuuauuagauaaauccgaugauucaugauaacucgacggaucgcacggccuucgugccggcgacgcaucauucaaauuucugcccuaucaacuuucgaugguaggauaggggccuaccaugguggugacgggugacggagaauuaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccugacacggggagguagugacaauaaauaacaauaccgggcgcauuagugucugguaauuggaaugaguacaaucuaaaucccuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuuaaguuguugcaguuaaaaagcucguaguuggaccuugggccggccggcaucgcgcuccuagcccggcaucguuacuuugaagaaauuagagugcucaaagcaagccaucgcucuggauacauuagcaugggauaacaucauaggauuccgguccuauuguguuggccuucgggaucggaguaaugauuaauagggacagucgggggcauucguauuucauagucagaggugaaauucuuggauuuaugaaagacgaacaacugcgaaagcauuugccaaggauguuuucauuaaucaagaacgaaaguugggggcucgaagacgaucagauaccguccuagucucaaccauaaacgaugccgaccagggaucggcggauguugcuuauaggacuccgccggcaccuuaugagaaaucaaagucuuuggguuccggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggcguggagccugcgcuuaauuugacucaacacggggaaacuuaccagguccagacauagcaaggauugacagacugagagcucuuucuugauucuaugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccguuaacgaacgagaccucagccugcuaacuagcuaugcggagccaucccuccgcagcuagcuucuuagagggacuauggccguuuaggccacggaaguuugaggcaauaacaggucugucaugcccuuagauguucugggccgcacgcgcgcuacacugauguauucaacgaguauauagccuuggccgacaggcccggguaaucuugggaaauuucaucgugauggggauagaucauugcaauuguuggucuucaacgaggaaugccuaguaagcgcgagucaucagcucgcguugacuacgucccugcccuuuguacacaccgcccgucgcuccuaccgauugaaugguccggugaaguguucggaucgcggcgacggacgucgcgagaaguccauugaaccuuaucauuuagaggaagcagaagucguaacaagguuuccguaggugaaccugcggaaggaucauug ...<<<<<.[.((((>>>>>.<<<.<<<<<<...<.<...<......<<<.<<<..<<....<<....<<...........>>...>>.>>......<<........<<<..<<..<<....<<<<<.............<.....<..<<<.....>>>..>......>...........<<<..<<....>>..>>>.<...<<<<<<..................>>>>>>.....>...<<<<.<<<<......>>>>>>>>..>>>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>..>>>..>....>.>.....<<<<<.<<..............>>.>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>..........<.<((.....<.<<...<<<.<<....<.<<<<..>>>>.>....................<<<<<<.<<.......<<...<.......>...<.......>.....>>......>>.>>..>>>>........<<..<<<<<<<...............>>>>>>>..>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<.<.....>>>>>>>>>>>>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<.......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<...<<<<<<<......>>>>>>>.....>>..>>>>.>>.....<<<<<.....>>>>>........>>>>>....>>>.>>>.....>>>>>>>.....>.>>>>>......>>>>.>>>.....<<<<.<.......<<.......<<<.<<<<....>>>>.>>>....>>........>.>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<.<<.<<....<<<<<<<..<<<..<<<<..<...<<<...<.......>...>>>...>..>>>>..>>>..>>>>>>>...>>.>>.>>..>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..)))).(((.((((((...(.(...((.....(((.(((..((....((....((...........))...))[))......(((.......(((..((..((....(((((.............(.....(..(((.....)))..)......)...........(((..((....))..))).(((.((((((.....{...(......).)))))).).).).(.((((.((((......))))))))).)))))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)....).).....((.(..((..............).).)..))......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..)))))))))...[......(.([[...(.(.((...(((..(......((.(..).))......................((((((.((.......((..((.......))................))......)).))..))))........((..(.((................}....))..).)).....)....(((.(((.((...((((..((..(((((((....((........)).......)))))))..)).......((....))...))))..)).)))..))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..((((((((.(((.(.....))))))))))))..)))...((..]]))...))...].))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((.......((........))..........(((((.(....(((((........((.(((........))).))......)))))...((.(((...(.((((((....((..(((((....)))..(.((......)))...))..))....(((((.((..((((..((...(((((((......))))))).....))..)))).))..(..(((((.....))))).....)..)))))....))).))).....).))))).....).)))))......)))).))).(...((((.(.......((.......(((.((((....)))).)))....))........).))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(.((.((.((..(.(((((((..(((..((((..(...(((...((.....))...)))...)..))))..)))..))))))))..)).)).))..).))...)..)..(((((((((....)))))))))}........ Wheat 80S ribosome pausing on AUG-Stop with cycloheximide; 18S ribosomal RNA 8ipb RB 3147 3.4 RF02543 38267667 0003735 0005840 4565 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..........................<<<<<.....<......>......>>>>>...........<<....>>..<<<<<.......<.....>......>>>>>..[[[....<......<<<<<<<<<...>>>>>>>>>......>......<<<<<<.<<<<.<<<<<<<.<<<<<<<.....<<<<......>>>>.((......<<<.....))>>>....>>>>>>>...>>>>>>>.....>>>>>>>>.>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<<<<<......<<<<<<<<.....>>>>>>>>.<..<<<<<<<<<<<<.<<<<<<<<<......<<<<<<<.......>>>>>>>.....>>>>>>>>>.>>>>>>>.....<<<<<<<....>>>.<<<<<<..>>>>>>..>>>>..>>>>>..>....>>>.>>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<....<<<<......>>>>.....>>...<<....>>....<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<.....<....>.....>>.>>>.>>....>>>>>>.>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<....<<<.<<<<<<<.....<<<....<<<....<<<.....<<<<.......>>>>...>>>....>>>..>.>>.....>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>.>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.......<..........<<<.<<<<<<.<<<.......<<<...<<.....<.........>.....>>........................>>>...>>>.>>>>>>>>>..........))).>....>>>>>>.>>>...>>>>>>><<<<.<<<<.........>>>>.>>>>....>>>>>><.<<<<<<<<<........<<<.<<<<....>>>>>>>.....>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<...<<<....>>>.........<<<<....>>>>....>>>....>>...<<<<<.........>>>>>))<<<<.<<<<<<<<...<<<....>>>...<...<<<<<<...<<<<.<<<<<<<.<<<<<.<<<<.......>>>>.><...<<<<<.....<<<<<<....<<<<...>>>>....>>>>>>.....>>>>>....><<<<..........>>>>>>>>...>>>>>>>.>>>>.........>>>>>>...>......>>>>.>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<...............>>>>><<.<<<<<<<<<<<.>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<....>>>>......>>>>>>>...<<<.<<<..<<<<<<.....<<.....<<<<....>>>>.....>>..>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<.<<<...<<<<<<<..>>>>>>>...<<<<<.....<<<<...<<<<....>>>>...............<<<<<<<.....>>>>>>>..>>>>..>>>>>......>>>.>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<<<.<.<<<......>>>.>...>>>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<..<<<<.<.<<<<<.................>>>>>.><<<<<...<<<<....<<<<<<<<<......>>>>..>>>>>...>>>>..>>>>>..<<<...<<<<<...........>>>>>...>>>..>>>>....>>>>>>>....<<<<<<<<<<<<......<<.......<<<<<<<..>>>>>>>....>>...........<<<...<<<<<<<<<<<......>>>>.>>>>>>>.>>>..................>>>>>>>>>>>>.<<<<<<<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>...>>>>>..>>>>>>.. ..........................((((......(...[..).......))))...........((....))...((((.......(.]...)......))))...((((.........((((((((((...)))))))))....)........((((((.((((.(((((((.(((((((...({((((......)))))[[(...).(((....}]])))....)))))))...))))))).....)))))))).))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((((((..(...((.((((.(....))))).)).(..((((((((((((.(((((((((......(((((((.......))))))).....))))))))).))))))).....(((((((....))).(((((....)))))..))))..)))))..)...)))).))))))))).[((((........))))((((((....((((((.((((((..((....((((......)))).....))...((....))....(((((..(((((....)))))...)))))((((((((.....(....).....)).))).)))...)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((........)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((....(((.(((((((.....(((....(((..(.(((....((((((.....))))))..))).)..)))..)).).....)))))...(((((((((.(......))))))))))....))))))).)))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((.......(..........(((.((((((.(((.....{.(((.(...(...................).........................))))...))).)))))))))..........]]].)....))))))))))...)))))))((((.((((.........)))).))))....))))))(((((((((((........(((.((((....))))))).....))))))))).)).....))))))((.....((.....((((((.......))))))((((.....((((..((...((((((...((.....)).))))))....[[(((.((...(((..((((....)))..)......((((....))))....)))....))...(((((.........)))))]]((((..(((((((..((((....)))...(..<((((((...((((.((((((((.((((.((((...{{..)))).)(...((((((....(((((.....(((.....))).....)))))...).)))))....)((((..........)))))))..).))))))).))))(...)....))))))...)).....)))).))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((.)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((....))))......))))))).}.(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.(.(.(((...(((((((..)))))))...(((((.....((((.(.((((....)))).).........>...((((((.......))))))..))))..)))))......))).).)..)))))...((......[))..((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..((..(.(((......))).)....)).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))....))..))).)))))....(((((((..((((...(((((......(....).....)))))..(((((...((((....((((((((((}}..)))))..)))))...))))..)))))..(((...((((.....}.......))))...)))..))))....)))))))....((((.(((((((....(.((.......(((((((..)))))))....)))..........(((...(((((.((((((...).)))).).))))).)))..................))))))).)))).(((((((..(.......)..).....(((((((((.(((....((((.(..(((((......)))))..)))))...)))....))))...)))))..)))))).. Wheat 80S ribosome pausing on AUG-Stop with cycloheximide; 60S ribosomal RNA 8ipb SB 160 3.4 RF00002 URS000080DD3B_4565 38267667 0003735 0005840 4565 cgacucucggcaacggauaucucggcucucgcaucgaugaagaacguagcgaaaugcgauaccuggugugaauugcagaaucccgugaaccaucgagucuuugaacgcaaguugcgcccgaggccauccggccgagggcacgccugccugggcgucacgc .........................................<<<<<<.((.....>>>....<<<<<<<.....))............>.>>>>.>>..>>>....<<.....>><<<<..<<<<....>>>>..>>>>..................... .........................................((((((.[[.....))).....((((((.....]]............).)))).)...)))....((.....))((((..((((....))))..))))..................... Wheat 80S ribosome pausing on AUG-Stop with cycloheximide; 5.8S ribosomal RNA 8ipb TB 120 3.4 RF00001 URS0000188192_4565 38267667 0003735 0005840 4565 ggaugcgaucauaccagcacuaaggcaucggaucccgucagaacuccgaaguuaagcgugcuugggcgagaguaguacaaggaugggugaccucuugggaaguccucguguugcauuccc <<<<<<<<<....<<<<<<<......<<<<<..............>>>..>>.....>>>>>.>><<<<<.<.....<.<<<<.<<....>>>>>>.>....>.>>>>>>>>>>>>>>.. (((((((((....(((((((......(.((((...(....)...))))...).....))))).))(((((.......(.(.((.((....)))).).)......)))))))))))))).. Wheat 80S ribosome pausing on AUG-Stop with cycloheximide; 5S ribosomal RNA 8ipb cl 75 3.4 38267667 4565 aucagagunncgcagcggaagcgungugggcccaunacccacagnnnncaggaucgnaaccuggcucugauacca <<<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((....[..)))).(.(((.......))).).....(((((..]....)))))))))))).... Wheat 80S ribosome pausing on AUG-Stop with cycloheximide; tRNAi 8ipd 8 156 3.2 RF00002,RF02540 URS00004B2C76_9606 37491604 0003735 0005840 9606 cgacucuuagcggnggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<.<<.....>>>.....(.<<<......>>.............>>>..)...>>>....<<....>><<<<<<<<<.....>>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))(((((((((.....))))))))).................... human nuclear pre-60S ribosomal particle - State C; 5.8S rRNA 8ipd 3 115 3.2 RF00001 URS000268145D_9606 37491604 0003735 0005840 9606 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggaccgccuggaauaccgggugcuguaggc <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<......<<.<<.<<<..>>>>>.>>....>>>>>>>>>>>>>>> (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((..........(..((..)).)........))))))))))))))) human nuclear pre-60S ribosomal particle - State C; 5S rRNA 8ipd 2 3485 3.2 RF02543 URS000268145C_9606 37491604 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugagnccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaanggaaaguugaaaagaacuuugaagngagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcggcccggcggaucuuucccgcgcgggggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcunggaaggcccggcggggaagguggcucgggggcccccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcncucuccccccucccggcgcgccggggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccgggggaggccacgcgcgcgucccccgaagagggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccnucuugaacncggaccaaggagucuaacacgngcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgagggngcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuagnacccnanagauggugancuaugccugggcagggcgaagccagaggaaacucuggugnagguccguagcgguccugacgugcaaaucgnucguccgaccuggguauagnggcgaaagacuaaucgaaccaucuaguagcuggnucccuccgaaguuucccucaggauagcuggcgcucucgcagacccgacgcccgccacgcaguuuuauccgguauggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcngaacuggcgcuncgggaugaaccgaacgccggguuaangcgcccgaugccgacgcucaucagacccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggaugncgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagcggcggcccggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcgnugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguagunnnaaauauucaaacganaacuuugaaggccgaaguggngaaggguuccaugugaacagnanuugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucgnguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccggggnagaggguguaaaucucgcnccgggccguaccnauauccgcagcaggucuncaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagcnggauccguaacuucgggauaaggauuggcucuaagggcugggucggucgcggccggcgccuagcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugccnagugcucugaaugucanagugnagaaauucaaugaagcgcggguaaacggcgguuaagancgagauucccacugucccuaccuacuauccagcgaaaccacngncaagggaacgngcuuggnggaaucagcngngaaagaaganccuguugagcuugacucuagucuggcacggugaaguuuuuucacugacccggngaggcgggggggcgagccccgaggggcucucgcuucuggcgccaancgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccaggugggnaguuuccugucgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuuuacgaauacagaccgugaaagcggggccgauccuucugaccuuuuggguuuuaagcaggagguaaguuaccacagggauaggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugunaagcagaauunaccaagcguungauuguucacccacuaauagggaacgugngcuggnnuuagancgucgugagacagnuuaguuuuacccuncugaugnuguguuguugccaugguaauccugcncaguacgagaggaaccgcagguncanacauuugguguaunugcuuggcugaggagccaauggggcgaagcuacnaucugugggauuaugacunaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccggucccccgccgggguccgguncngagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<<....<......>.....>>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..[[[..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>>..<<<<<<<<<<...<<<<<<<<........<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>...>>>>>>>>..>>>>>>>>>>.......<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<<<..<<<<<<<.......<<....<<<<.<<<..<<<<..>>>>>>>>>>>>>......>>>>...>>>>>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<<<<<<<<<<<<<<<<<...<<..<<<..<.<<<<......<<<<<<<<..>>>>>>>>.......>>>>.>.>>>........>>>>>>..>>>>>>>>>>>....................<<<<<<.<<<<<<<............>>>>>>>.<<<<<<.<<<<.<<<<<<<<<<.<<<<<..<<<<....<<......>>....>>>>..>>>>.>.>>>>>>>.>>>...>>>>..>>>>.>>..<<<<<<<<<.......>>>>>>>.>>....>>>>>>.....>>>.>>>>>...>>>>>...>>>>>>>>..<<<<.......>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<......>>>>>>>..<<<<<...<<<..<<<..(((...(((>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<........>.><<.<<<<<<<......................<<<.<<<<<<<<<...>>>>>>>...<<<<<<<<<.........>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<.........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<..........)))...)))............................>>>>>>>>>....>>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<....<<.....>>..>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<...<<...>>...>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<...<<<<.<<....>>.>>>>...<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<<<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>.>.>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<...............<<<<<....<....>.....>>>>><<.<<<<<<<<<<<..<............>.......>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>.......<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>>.........>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....(((((..[[[........(((((.[[((((..<<<<..<<<<<<<<<.<<<<<<...>>>>>>...<<<<<.....<<<<.....<<............>>................<.<<<<<<<<.......>>>>>>>>.>..>>>>..>>>>>....>>>>>>>>>...>>>>...<<......>>..........<<<<<...<<<<<<.......>>>>>>...........((......>>>>>.....<<<..<<<<....>>>>..>>>.<<<....>>>...)).....((((...(((..>>>>>>.))).))))....))))..]])))))..........<<<<<<.................>>>>>>.................<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>>......<<<<<<<....>>>.>>>>........]]].))))).....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<.]]]..>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.....<<<<<<..<<..<<<<....<<<........<<<<<.<<<<....>>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>..............>>>>..>>.>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<.<..<<<<<......>>>>>..>>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((...((((((((((.....)))))).)))).....)))....((((((((((...((.(((((........((((((((..({((((......)))))....[[(...).(((....}]])))...).)))))))...))))).))..))))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....(((((((((((..(((((((.......((.....(((.(((...(.(..).).)))))).))......))))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((..(.((((......(.((((((..)))))).).......)))).).)))........))))))..)))))))))))....................((((((.((((((..............)))))).((((((.((((.((((((((((.(((((..(((.....((......)).....)))..)))).).))))))).)))...))))..)))).))..((((((((.........)))))).))..[.)))))).....))).)))))...)))))...))))))))..((((.......))))((((((....(((((((((((((..(((..(((((........))))..)..)))...((....))...(((((.(......).)))))..(((((...(((..(((..[......[[)))..)))....))))).((((.((((.(((((...).)))))))).)).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(........).)((.(((((((......................(((.(((((((.......)))))...(((((((((.(......))))))))))....))))))))))))..))..((((.(..((.....))..).))))....(((......)))...(((((((...((([[[...(.(.(((((......(.........(((.((((((((((.....{.(((((.(.(...((.........))...).).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((..........]]......]]..............(...)........)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...((....(((....)))..........((.((((....(....)...))))))......))....))...(((((........)))))]]((((....(((((...((.(.((....)).).))..((((....)))...(...((((((...(((((((((((((((((((((((..{{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....(((((((.......))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((...(.(.......))........)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).]......((..((((((.(..(((.....((((....)))).....))))))))..)))).(..).....)).))))))).)..))).)))))))..))))))....)).[..(((((......].)))))....(((((..((((.......(((((.((((((..(((((.(((((((((.(((((.....)))))...(((((.....((((.....((............))................(.((((((((.......)))))))).)..))))..)))))....)))))))))..)))))...((......))..........(((((.(.((((((.......))))))...).......[.[.....))))).....(((..((((....))))..))).(((....)))...]]....((.(.(..(((..]]]]]].)))).).).)..))))..)))))))..........((((((.....(.......)...))))))..................(((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).......(((((((....))).))))..a..)..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}}.)))))..)).))...))))...)))).((((...((((.....}.......))))...))))..)))...).)))))).....((((((..((..((((.(..(((........(((((.((((....)))).))))).......)))...(((..((((....((((.(((((((......)))))))))))...))))..)))...........)..))))..)).))))))(((((.(..(.......)..)....((.(((((((.((.....((((.(..(((((......)))))..)))))....))....)))).))).))..))))).. human nuclear pre-60S ribosomal particle - State C; 28S rRNA 8ipx 2 3475 4.3 RF02543 URS000268145C_9606 37491604 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugagnccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaanggaaaguugaaaagaacuuugaagngagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcggcccggcggaucuuucccgcgcgggggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcunggaaggcccggcggggaagguggcucgggggcccccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcncucuccccccucccggcgcgccggggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccgggggaggccacgcgcgcgucccccgaagagggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccnucaaacncggaccaaggagucuaacacgngcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgagggngcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuagnacccnanagauggugancuaugccugggcagggcgaagccagaggaaacucuggugnagguccguagcgguccugacgugcaaaucgnucguccgaccuggguauagnggcgaaagacuaaucgaaccaucuaguagcuggnucccuccgaaguuucccucaggauagcuggcgcucucgcagacccgacgcccgccacgcaguuuuauccgguauggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcngaacuggcgcuncgggaugaaccgaacgccggguuaangcgcccgaugccgacgcucaucagacccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggaugncgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagcggcggcccggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcgnugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguagunnnaaauauucaaacganaacuuugaaggccgaaguggngaaggguuccaugugaacagnanuugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccugcccuccgaucgaaagggagucgnguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccggggnagaggguguaaaucucgcnccgggccguaccnauauccgcagcaggucuncaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagcnggauccguaacuucgggauaaggauuggcucuaagggcugggucggucgcggccggcgccuagcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugccnagugcucugaaugucanagugnagaaauucaaugaagcgcggguaaacggcgguuaagancgagauucccacugucccuaccuacuauccagcgaaaccacngncaagggaacgngcuuggnggaaucagcngngaaagaaganccuguugagcuugacucuagucuggcacggugaaguuuuuucacugacccggngaggcgggggggcgagccccgaggggcucucgcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccaggugggnaguuuccugucgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuuuacgaauacagaccgugaaagcggggccgauccuucugaccuuuuggguuuuaagcaggagguaaguuaccacagggauaggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugunaagcagaauunaccaagcguungauuguucacccacuaauagggaacgugngcuggnnuuagancgucgugagacagnuuaguuuuacccuncugaugnuguguuguugccaugguaauccugcncaguacgagaggaaccgcagguncanacauuugguguaunugcuuggcugaggagccaauggggcgaagcuacnaucugugggauuaugacunaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccggucccccgccgggguccgguncngagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..[[[..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>>..<<<<<<<<<<...<<<<<<<<........<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>...>>>>>>>>..>>>>>>>>>>.......<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<......>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<<<..<<<<<<<.......<<....<<<<.<<<..<<.<..>.>>>>>>>>>>>......>>>>...>>>>>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<<<<<<<<<<<<.<<<<...<<..<<<..<.<<<<......<<<<<<<<..>>>>>>>>.......>>>>.>.>>>........>>>>>>...>>>>>>>>>>....................<<<<<<.<<<<<<<............>>>>>>>.<<<<<<.<.<<.<<<<<<<<<<.<<<<<<.<<<<<................>>>>>.>>>>>.>.>>>>>>>.>>>...>>.>..>>>>.>>..<<<<<<<<<.......>>>>>>>.>>....>>>>>>.....>>>.>>>>>...>>>>>...>>>>>>>>..<<<<.....>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<......>>>>>>>..<<<<<...<<<..<<<..[[....(((>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<........>.><<<<<<<<<<......................<<<.<<<<<<.........>>>>...<<<<<<<<<.........>>>>>>>>>....>>>>>>>>>>>>.>>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<.........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<..........)))....]]............................>>>>>>>>>....>>>>>>.<<<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>.>>.....>>>>>><<<....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<....<<.....>>..>>>>>....((<<<<<<...<<....<<<....>>>.............<<<<........>>>>.....>>....>>>..<<<<<........>>>>>))<<<<....<<<<<...<<<<<<<....>>>>>>>...<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<<<<<<<<<<<<..{{{..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>.>.>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<...............<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<..<............>.......>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>.......<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>>.........>>.>>>>>>>.....>>.>>>>>>>..>>>>>>...>>>....<<<<<........>>>>>....(((((..{{{........(((((.{{[[[[..<<<<<.<<<<<<<<<.<<<<<<...>>>>>>...<<<<<.....<<<<.....<..............>................<<<<<<<<<<<.....>>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<......>>.........<<<<<<...<<<<<<.......>>>>>>...........((......>>>>>>....<<<..<<<<....>>>>..>>>.<<<....>>>...))....(((((...(((..>>>>>>.))).)))))...]]]]..}})))))..........<<<<<<.................>>>>>>.................<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>>......<<<<<<<....>>>.>>>>........}}}.))))).....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<.}}}..>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.....<<<<<<<.<<..<<<<....<<<........<<<<<.<<<<....>>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>..............>>>>..>>>>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<.<..<<<<<......>>>>>..>>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((...((((((((((.....)))))).)))).....)))....((((((((((...((.(((((...(....((((((((..({((((......)))))....[[(...).(((....}]])))...).))))))))..))))).))..))))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....(((((((((((..(((((((..(....((....((((.((....(......)..))))))))...)..))))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((..(.((((......(.((((((..)))))).).......)))).).)))........))))))..)))))))))))....................((((((.((((((..............)))))).((((((.(.((.((((((((((.(((((..(((......(......)......)))..)))).).))))))).)))...)).)..)))).))..((((((((.........)))))).))..[.)))))).....))).)))))...)))))...))))))))..((((.....))))((((((....(((((((((((((..(((..(((((........))))..)..)))...((....))...((((((........))))))..(((((...(((..(((..[......[[)))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(........).)((.(((((((......................(((.(((((((.......)))))...(((((((((.(......))))))))))....))))))))))))..))..((((.(..((.....))..).))))....(((......)))...(((((((...((([[[...(.(.(((((......(.........(((.((((((((((.....{.(((((.(.(...((.........))...).).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((..........]]......]]..............(...)........)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...((....(((....))).........(...((((........)))))....))....))...(((((........)))))]]((((....(((((...((.(((......))).))..((((....)))...(...((((((...(((((((((((((((((((((((..{{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((...(.(.......))........)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].....(((..((((((.(...((.....((((....)))).....)).)))))..))))).........)).))))))).)..))).)))))))..))))))....)).[..(((((......].)))))....(((((..((((.......(((((.((((((..(((((.(((((((((.((((((...))))))...(((((.....((((.....(..............)................((((((((((.......))))))))))..))))..)))))....)))))))))..)))))...((......))........(.(((((.(.((((((.......))))))...).......[.......)))))..)..(((..((((....))))..))).((......))....]....((.(.(..(((..]]]]]].)))).).))...))))..)))))))..........((((((.....(.......)...))))))..................(((.((((((..(.(.((((........))))...).).(((.(.....).))).....)))))..)...))).......(((((((....))).))))..a..)..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}}.)))))..)).))...))))...)))).((((...((((.....}.......))))...))))..)))...).)))))).....((((((..((..((((.(..(((........(((((.((((....)))).))))).......)))...(((...((.....((((.(((((((......)))))))))))....))...)))...........)..))))..)).))))))(((((.(..(.......)..)....((.(((((((.((.....((((.(..(((((......)))))..)))))....))....)))).))).))..))))).. human nuclear pre-60S ribosomal particle - State C'; 28S rRNA 8ipx 8 156 4.3 RF00002,RF02540 URS00004B2C76_9606 37491604 0003735 0005840 9606 cgacucuuagcggnggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<.<<.....>>>.....(.<<<......>>.............>>>..)...>>>....<<....>><<<<<<<<<.....>>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))(((((((((.....))))))))).................... human nuclear pre-60S ribosomal particle - State C'; 5.8S rRNA 8ipx 3 115 4.3 RF00001 URS000268145D_9606 37491604 0003735 0005840 9606 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggaccgccuggaauaccgggugcuguaggc <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<.......<.<<.<<<..>>>>>.>.....>>>>>>>>>>>>>>> (.((((.((....((((((((.....((((((...(....)...))))..))....)))))).))((((((..........(..((..)).)........)))))))).)))).) human nuclear pre-60S ribosomal particle - State C'; 5S RNA 8ipy 2 3485 3.2 RF02543 URS000268145C_9606 37491604 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugagnccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaanggaaaguugaaaagaacuuugaagngagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcggcccggcggaucuuucccgcgcgggggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcunggaaggcccggcggggaagguggcucgggggcccccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcncucuccccccucccggcgcgccggggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccgggggaggccacgcgcgcgucccccgaagagggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccnucaaacncggaccaaggagucuaacacgngcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgagggngcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuagnacccnanagauggugancuaugccugggcagggcgaagccagaggaaacucuggugnagguccguagcgguccugacgugcaaaucgnucguccgaccuggguauagnggcgaaagacuaaucgaaccaucuaguagcuggnucccuccgaaguuucccucaggauagcuggcgcucucgcagacccgacgcccgccacgcaguuuuauccgguauggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcngaacuggcgcuncgggaugaaccgaacgccggguuaangcgcccgaugccgacgcucaucagacccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggaugncgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagcggcggcccggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcgnugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguagunnnaaauauucaaacganaacuuugaaggccgaaguggngaaggguuccaugugaacagnanuugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccugcccuccgaucgaaagggagucgnguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccggggnagaggguguaaaucucgcnccgggccguaccnauauccgcagcaggucuncaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagcnggauccguaacuucgggauaaggauuggcucuaagggcugggucggucgcggccggcgccuagcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugccnagugcucugaaugucanagugnagaaauucaaugaagcgcggguaaacggcgggaguacucucuuaagancgagauucccacugucccuaccuacuauccagcgaaaccacngncaagggaacgngcuuggnggaaucagcngngaaagaaganccuguugagcuugacucuagucuggcacggugaaguuuuuucacugacccggngaggcgggggggcgagccccgaggggcucucgcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccaggugggnaguuuccugucgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuuuacgaauacagaccgugaaagcggggccgauccuucugaccuuuuggguuuuaagcaggagguaaguuaccacagggauaggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugunaagcagaauunaccaagcguungauuguucacccacuaauagggaacgugngcuggnnuuagancgucgugagacagnuuaguuuuacccuncugaugnuguguuguugccaugguaauccugcncaguacgagaggaaccgcagguncanacauuugguguaunugcuuggcugaggagccaauggggcgaagcuacnaucugugggauuaugacunaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccggucccccgccgggguccgguncngagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..[[[..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>>..<<<<<<<<<<...<<<<<<<<........<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>...>>>>>>>>..>>>>>>>>>>.......<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<......>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<<<..<<<<<<<.......<<....<<<<.<<<..<<.<..>.>>>>>>>>>>>......>>>>...>>>>>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<<<<<<<<<<<<.<<<<...<<..<<<..<.<<<<......<<<<<<<<..>>>>>>>>.......>>>>.>.>>>........>>>>>>...>>>>>>>>>>....................<<<<<<.<<<<<<<............>>>>>>>.<<<<<<.<.<<.<<<<<<<<<<.<<<<<<.<<<<<................>>>>>.>>>>>.>.>>>>>>>.>>>...>>.>..>>>>.>>..<<<<<<<<<.......>>>>>>>.>>....>>>>>>.....>>>.>>>>>...>>>>>...>>>>>>>>..<<<<.....>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<......>>>>>>>..<<<<<...<<<..<<<..[[....(((>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<........>.><<<<<<<<<<......................<<<.<<<<<<.........>>>>...<<<<<<<<<.........>>>>>>>>>....>>>>>>>>>>>>.>>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<.........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<..........)))....]]............................>>>>>>>>>....>>>>>>.<<<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>.>>.....>>>>>><<<....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<....<<.....>>..>>>>>....((<<<<<<...<<....<<<....>>>.............<<<<........>>>>.....>>....>>>..<<<<<........>>>>>))<<<<....<<<<<...<<<<<<<....>>>>>>>...<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<<<<<<<<<<<<..{{{..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>.>.>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<...............<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<..<............>.......>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>.......<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<.<...>.>>>......>>.>>>>>>>.....>>.>>>>>>>..>>>>>>...>>>....<<<<<........>>>>>....(((((..{{{........(((((.{{[[[[..<<<<<.<<<<<<<<<.<<<<<<...>>>>>>...<<<<<.....<<<<.....<..............>................<<<<<<<<<<<.....>>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<......>>.........<<<<<<...<<<<<<.......>>>>>>...........((......>>>>>>....<<<..<<<<....>>>>..>>>.<<<....>>>...))....(((((...(((..>>>>>>.))).)))))...]]]]..}})))))..........<<<<<<.................>>>>>>.................<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>>......<<<<<<<....>>>.>>>>........}}}.))))).....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<.}}}..>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.....<<<<<<<.<<..<<<<....<<<........<<<<<.<<<<....>>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>..............>>>>..>>>>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<.<..<<<<<......>>>>>..>>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((...((((((((((.....)))))).)))).....)))....((((((((((...((.(((((...(....((((((((..({((((......)))))....[[(...).(((....}]])))...).))))))))..))))).))..))))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....(((((((((((..(((((((..(....((....((((.((....(......)..))))))))...)..))))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((..(.((((......(.((((((..)))))).).......)))).).)))........))))))..)))))))))))....................((((((.((((((..............)))))).((((((.(.((.((((((((((.(((((..(((......(......)......)))..)))).).))))))).)))...)).)..)))).))..((((((((.........)))))).))..[.)))))).....))).)))))...)))))...))))))))..((((.....))))((((((....(((((((((((((..(((..(((((........))))..)..)))...((....))...((((((........))))))..(((((...(((..(((..[......[[)))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(........).)((.(((((((......................(((.(((((((.......)))))...(((((((((.(......))))))))))....))))))))))))..))..((((.(..((.....))..).))))....(((......)))...(((((((...((([[[...(.(.(((((......(.........(((.((((((((((.....{.(((((.(.(...((.........))...).).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((..........]]......]]..............(...)........)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...((....(((....))).........(...((((........)))))....))....))...(((((........)))))]]((((....(((((...((.(((......))).))..((((....)))...(...((((((...(((((((((((((((((((((((..{{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((...(.(.......))........)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].....(((..((((((.(...((.....((((....)))).....)).)))))..))))).(.........).......)).))))))).)..))).)))))))..))))))....)).[..(((((......].)))))....(((((..((((.......(((((.((((((..(((((.(((((((((.((((((...))))))...(((((.....((((.....(..............)................((((((((((.......))))))))))..))))..)))))....)))))))))..)))))...((......))........(.(((((.(.((((((.......))))))...).......[.......)))))..)..(((..((((....))))..))).((......))....]....((.(.(..(((..]]]]]].)))).).))...))))..)))))))..........((((((.....(.......)...))))))..................(((.((((((..(.(.((((........))))...).).(((.(.....).))).....)))))..)...))).......(((((((....))).))))..a..)..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}}.)))))..)).))...))))...)))).((((...((((.....}.......))))...))))..)))...).)))))).....((((((..((..((((.(..(((........(((((.((((....)))).))))).......)))...(((...((.....((((.(((((((......)))))))))))....))...)))...........)..))))..)).))))))(((((.(..(.......)..)....((.(((((((.((.....((((.(..(((((......)))))..)))))....))....)))).))).))..))))).. human nuclear pre-60S ribosomal particle - State D'; 28S rRNA 8ipy 8 156 3.2 RF00002,RF02540 URS00004B2C76_9606 37491604 0003735 0005840 9606 cgacucuuagcggnggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<.<<.....>>>.....(.<<<......>>.............>>>..)...>>>....<<....>><<<<<<<<<.....>>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))(((((((((.....))))))))).................... human nuclear pre-60S ribosomal particle - State D'; 5.8S rRNA 8ipy 3 115 3.2 RF00001 URS000268145D_9606 37491604 0003735 0005840 9606 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggaccgccuggaauaccgggugcuguaggc <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<.......<.<<.<<<..>>>>>.>.....>>>>>>>>>>>>>>> (.((((.((....((((((((.....((((((...(....)...))))..))....)))))).))((((((..........(..((..)).)........)))))))).)))).) human nuclear pre-60S ribosomal particle - State D'; 5S rRNA 8ir1 2 3369 3.3 RF02543 URS000268145C_9606 37491604 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugagnccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaanggaaaguugaaaagaacuuugaagngagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcggcccggcggaucuuucccgcgcgggggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcunggaaggcccggcggggaagguggcucgggggcccccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcncucuccccccucccggcgcgccggggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccgggggaggccacgcgcgcgucccccgaagagggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccnucaaacncggaccaaggagucuaacacgngcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgagggngcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuagnacccnanagauggugancuaugccugggcagggcgaagccagaggaaacucuggugnagguccguagcgguccugacggcaaaucgnucguccgaccuggguauagnggcgaaacuaaucaccaucuaguagcuggnucccuccgaaguuuccccaggauagcuggcgcucucgcgcaguuuuauccgguaaaacuuuaaaungguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcngaacuggcgcuncgggaugaaccgaacgccggguuaangcgcccgaugccgacgcucaucagacccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggaugncgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagcggcggcccggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcgnugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguagunnnaaauauucaaacganaacuuugaaggccgaaguggngaaggguuccaugugaacagnanuugaacaugggucagucgguccugagagaugggcgagcgccguuccgaacgaucgaaagggagucgnguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccggggnagaggguguaaaucucgcnccgggccguaccnauauccgcagcaggucuncaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagcnggauccguaacuucgggauaaggauuggcucuaagggcuguagcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucaaagugaagaaaucaaugaaggaguaacuaugacucucgguagccaaaugancgagauucccacugucccuaccuacuauccagcgaaaccacngncaagggaacgngcuuggnggaaucagcngngaaagaaganccuguugagcuugacucuagucuggcacggugaaguuuuuucacugacccggngaggcggccgcuccggggacagugccaggugggnaguuugagggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuacagggauaggcuuguggcggccangcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugunaagcagaauunaccaagcguungauuguucacccacuaauagggaacgugngcuggguuagaccgucgugagacagnuuaguuuuacccuncugaugauguguuguugccaugguaauccugcncaguacgagaggaaccgcagguncanacauuugguguaunugcuuggcugaggagccaauggggcgaagcuacnaucugugggauuaugacunaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccggucccccgccgggguccgguncngagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..[[[..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>>..<<<<<<<<<<...<<<<<<<<........<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>...>>>>>>>>..>>>>>>>>>>.......<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<......>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<<<..<<<<<<<.......<<....<<<<.<<<..<<<<..>>>>>>>>>>>>>......>>>>...>>>>>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<<<<<<<<<<<<<<<<<...<<..<<<..<.<<<<......<<<<<<<<..>>>>>>>>.......>>>>.>.>>>........>>>>>>..>>>>>>>>>>>....................<<<<<..<<<<<<..............>>>>>>.<<<<<<.<<<<.<<<<<<<<<<.<<<<<<.<<<<....<<......>>....>>>>.>>>>>.>.>>>>>>>.>>>...>>>>..>>>>.>>..<<<<<<<<<.......>>>>>>>.>>.....>>>>>.....>>>.>>>>>...>>>>>...>>>>>>>>..<<<<.....>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<......>>>>>>>..<<<<<...<<<..<<<..(((...(((>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<.......>>>>.>>>....>>>>>>>>>...<<.....>>....>>>>>>......>.>>..<<<<<<....<.<<<...>>>.><<<<<<<<<<....<<<.<<<<<<<................>.>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>>>>>>.>>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<.........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<..........)))...)))............................>>>>>>>>>....>>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<<....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<....<<.....>>..>>>>>....((<<<<<<...<<....<<<....>>>...........>>....>>>..<<<<<........>>>>>))<<<<....<<<<<...<<<<.<<....>>.>>>>...<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<<<<<<<<<<<<..{{{..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>.>.>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<...............<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<...>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<......<<<.....>>>.....<<.<..........>.>>.........>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>...>>>....<<<<<........>>>>>....(((((..{{{........(((((...[[[[..<<<.<.<<<<<<<<<.<<<<<.....>>>>>...<<<<<.....<<..>>..>>>>>....>>>>>>>>>...>>>.>.....<.<..<<<<<<<<...........>>>>>>>>.....<<<<<<<...<<<<<<.......>>>>>>.....<<......>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>><<<<....>>>>..>.>.......(((((...(((..>>>>>>.))).)))))..........]]]].)))))..........<<<<<<...<<.......>>...>>>>>>.................<<<<..<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>...>...>>>>.....<<<<<<<....>>>.>>>>........}}}.))))).....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<}}}.>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.....<<<<<<..<<..<<<<....<<<........<<<<<.<<<<....>>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>..............>>>>..>>.>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<.<..<<<<<......>>>>>..>>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((...((((((((((.....)))))).)))).....)))....((((((((((...((.(((((...(....((((((((..({((((......)))))....[[(...).(((....}]])))...).))))))))..))))).))..))))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....(((((((((((..(((((((.......((....((((.((....(.(..).)..))))))))......))))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((..(.((((......(.((((((..)))))).).......)))).).)))........))))))..)))))))))))....................((((((.(((((((............))))))).((((((.(.((.((((((((((.(((((..(((.....((......)).....)))..)))).).))))))).)))...)).)..)))).))..((((((((.........)))))).))..[.)))))).....))).)))))...)))))...))))))))..((((.....))))((((((....(((((((((((((..(((..(((((........))))..)..)))...((....))...(((((.(......).)))))..(((((...(((..(((..[......[[)))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......)))).)))..).))))))))).(.((.....))...)))))))......).))..((((((....(.(((...))).)((.(((((((....(((.(((((.(................)..)))...(((((((((.(......))))))))))....))))))))))))..))..((((.(.(((.....))).).))))....(((......)))...(((((((...((([[[...(.(.(((((......(.........(((.((((((((((.....{.(((((.(.(...((.........))...).).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((..........]]......]]..............(...)........)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...((....(((....)))...........))....))...(((((........)))))]]((((....(((((...((.(.(......).).))..((((....)))...(...((((((...(((((((((((((((((((((((..{{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....(((((((.......))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((...)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(......(((.....))).....(.(.............)).........)....)).))))))).)..))).)))))))..))))))....)).[..(((((......].)))))....(((((..(((........(((((.(.(.((..(.(.(.(.(.(((((.(((((.....)))))...(((((.....((()))..)))))....))))).).)...))..).......((..((((.((...........)).))))......(((((((...((((((.......)))))).....((......))....)))))))...(((..(.............)..)))((((....))))..))........((((((..(((..]]]]]].)))))))).).........)).)))))))..........((((((.................))))))..................(((..(((((..(.(.((((........))))...).).(((.(.....).))).....)))))......)))......(((((((....))).))))........))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}}.)))))..)).))...))))...)))).((((...((((.....}.......))))...))))..)))...).)))))).....((((((..((..((((.(..(((........(((((.((((....)))).))))).......)))...(((..(((.....((((.(((((((......)))))))))))....)))..)))...........)..))))..)).))))))(((((.(..(.......)..)....((.(((((((.((.....((((.(..(((((......)))))..)))))....))....)))).))).))..))))).. human nuclear pre-60S ribosomal particle - State A; 28S rRNA 8ir1 8 155 3.3 RF00002,RF02540 URS00004B2C76_9606 37491604 0003735 0005840 9606 cgacucuuagcggnggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<.<<.....>>>.....(.<<<......>>.............>>>..)...>>>....<<...>><<<<<<<<<.....>>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((...))(((((((((.....))))))))).................... human nuclear pre-60S ribosomal particle - State A; 5.8S rRMA 8ir3 8 155 3.5 RF00002,RF02540 URS00004B2C76_9606 37491604 0003735 0005840 9606 cgacucuuagcggnggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<.<<.....>>>.....(.<<<......>>.............>>>..)...>>>....<<...>><<<<<<<<<.....>>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((...))(((((((((.....))))))))).................... human nuclear pre-60S ribosomal particle - State B'; 5.8S rRNA 8ir3 2 3541 3.5 RF02543 URS000268145C_9606 37491604 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugagnccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaanggaaaguugaaaagaacuuugaagngagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcggcccggcggaucuuucccgcgcgggggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcunggaaggcccggcggggaagguggcucgggggcccccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcncucuccccccucccggcgcgccggggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccgggggaggccacgcgcgcgucccccgaagagggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccnucuugaacncggaccaaggagucuaacacgngcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgagggngcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuagnacccnanagauggugancuaugccugggcagggcgaagccagaggaaacucuggugnagguccguagcgguccugacgugcaaaucgnucguccgaccuggguauagnggcgaaagacuaaucgaaccaucuaguagcuggnucccuccgaaguuucccucaggauagcuggcgcucucgcagacccgacgcccgccacgcaguuuuauccgguaaaacuuuaaaungguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcngaacuggcgcuncgggaugaaccgaacgccggguuaangcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggaugncgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagcggcggcccggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcgnugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguagunnnaaauauucaaacganaacuuugaaggccgaaguggngaaggguuccaugugaacagnanuugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggcccucggccgaucgaaagggagucgnguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccggggnagaggguguaaaucucgcnccgggccguaccnauauccgcagcaggucuncaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagcnggauccguaacuucgggauaaggauuggcucuaagggcugggucggucgcggccggcgccuagcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugccnagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaancgagauucccacugucccuaccuacuauccagcgaaaccacngncaagggaacgngcuuggnggaaucagcngngaaagaaganccuguugagcuugacucuagucuggcacggugaaguuuuuucacugacccggngaggcgggggggcgagccccgaggggcucucgcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccaggugggnaguuugggcgguacaccugucaaacgguaacgcaggugucaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacaggguggcuuguggcggccangcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugunaagcagaauunaccaagcguungauuguucacccacuaauagggaacgugngcuggguuuagancgucgugagacagnuuaguuuuacccuncugaugauguguuguugccaugguaauccugcncaguacgagaggaaccgcagguncanacauuugguguaunugcuuggcugaggagccaauggggcgaagcuacnaucugugggauuaugacunaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccggucccccgccgggguccgguncngagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..[[[..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>>..<<<<<<<<<<...<<<<<<<<........<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>...>>>>>>>>..>>>>>>>>>>.......<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<......>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<<<..<<<<<<<....<..<<....<<<<.<<<..<<.<..>.>>>>>>>>>>>.>....>>>>...>>>>>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<<<<<<<<<<<<<<<<<...<<..<<<..<.<<<<......<<<<<<<<..>>>>>>>>.......>>>>.>.>>>........>>>>>>..>>>>>>>>>>>....................<<<<<..<<<<<<<............>>>>>>>.<<<<<<.<<<<.<<<<<<<<<<.<<<<<<.<<<<<...<<......>>...>>>>>.>>>>>.>.>>>>>>>.>>>...>>>>..>>>>.>>..<<<<<<<<<.......>>>>>>>.>>.....>>>>>.....>>>.>>>>>...>>>>>...>>>>>>>>..<<<<.......>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<......>>>>>>>..<<<<<...<<<..<<<..[[....(((>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<......>>.><<<<<<<<<<......................<<<.<<<<<<<................>.>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>>>>>>.>>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<..........)))....]]............................>>>>>>>>>....>>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<<....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<....<<.....>>..>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<........>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<...<<<<<<<....>>>>>>>...<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<<<<<<<<<<<<..{{{..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>.>.>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<...............<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<..<............>.......>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>.......<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>>...<<.........>>.................>>.>>>>>>>.....>>.>>>>>>>..>>>>>>...>>>....<<<<<........>>>>>....(((((..{{{........(((((.{{[[[[..<<<<..<<<<<<<<<.<<<<<.....>>>>>...<<<<<.....<<<<.....<..............>................<<<<<<<<<<.......>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>...>>>.>...<.<..<<<<<<<<...........>>>>>>>>...<<<<<<<...<<<<<<.......>>>>>>.....<<......>>....>>>>>>>...<<<..<<<.........>>>..>>><<<<....>>>>..>.>.......(((((...(((..>>>>>>.))).)))))..........]]]]..}})))))........<<<<<<...<<.......>>...>>>>>>................<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>>>.....<<<<<<<....>>>.>>>>........}}}.))))).....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<}}}.>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.....<<<<<<<.<<..<<<<....<<<........<<<<<.<<<<....>>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>..............>>>>..>>>>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<....<<<<<......>>>>>...>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((...((((((((((.....)))))).)))).....)))....((((((((((...((.(((((........((((((((..({((((......)))))....[[(...).(((....}]])))...).)))))))...))))).))..))))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....(((((((((((..(((((((.......((....((((.((....(.(..).)..))))))))......))))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((..(.((((......(.((((((..)))))).).......)))).).)))........))))))..)))))))))))....................((((((.(((((((............))))))).((((((.(.((.((((((((((.(((((..(((.....((......)).....)))..)))).).))))))).)))...)).)..)))).))..((((((((.........)))))).))..[.)))))).....))).)))))...)))))...))))))))..((((.......))))((((((....(((((((((((((..(((..(((((........))))..)..)))...((....))...(((((.(......).)))))..(((((...(((..(((..[......[[)))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((......................(((.(((((((................).))))...(((((((((.(......))))))))))....))))))))))))..))..((((.(.(((.....))).).))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.....{.(((((.(.(...((.........))...).).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((..........]]......]]..............(...)........)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...((....(((....)))..........((.((........))))......))....))...(((((........)))))]]((((....(((((...((.(.((....)).).))..((((....)))...(...((((((...(((((((((((((((((((((((..{{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....(((((((.......))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(....).....)))))((.(((((((((((...(.(.......))........)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......)))))))............((.(((....((......((((....))))......)).)))...)).....(..............)...............)).))))))).)..))).)))))))..))))))....)).[..(((((......].)))))....(((((..((((.......(((((.((((((..(((...(.(.(((((.(((((.....)))))...(((((.....((((.....(..............)................((((((((((.......))))))))))..))))..)))))....))))).).)....)).).....(...(((((((...........)))))))....(((((((...((((((.......)))))).....((......))....)))))))...(((..(.............)..))).(((....)).)..).........(..(((..(((..]]]]]].))))))...).........))))..)))))))........((((((.................))))))..................(((.((((((..(.(.((((........))))...).).(((.(.....).))).....)))))..)...))).......(((((((....))).))))..a..)..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}}.)))))..)).))...))))...)))).((((...((((.....}.......))))...))))..)))...).)))))).....((((((..((..((((.(..(((........(((((.((((....)))).))))).......)))...(((..(((.....((((.(((((((......)))))))))))....)))..)))...........)..))))..)).))))))(((((.(..(.......)..)....((.(((((((.((.....((((.(..(((((......)))))..)))))....))....)))).))).))..))))).. human nuclear pre-60S ribosomal particle - State B'; 28S rRNA 8j1z a 2513 2.6 RF02541 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcgcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaauaacgguccuaagguagcgacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaagaccccgunaaccuuuacuauagcuugacacugaacauugaguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgnggagucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>>.>>...............<<....>>....>>.........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<........>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<.>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<.......>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<..>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....[[[...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.......<<<<<<.<<....>>..>>>>>>.......>>>>>>>>>..>>>>><<<<<<....>>>>>>........<...>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.<<<.<<<...<<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<....>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>>..>>>...>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]].>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((.(((......))).))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((.)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(..).))...........]]].)...))))))))))...)))))))((((((((()))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(.(((......))).)........(...)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.(((...(((((.((((((..(((((.(((.(((((.(((((((((..)))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..)))))))..)))...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). The global structure of pre50S related to DbpA in state3; 23S rRNA 8j1z b 119 2.6 RF00001 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>> ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))) The global structure of pre50S related to DbpA in state3; 5S rRNA 8jdj A 14 2.5 37992713 9606 ugaugaugaugaug .............. .............. Structure of the Human cytoplasmic Ribosome with human tRNA Asp(Q34) and mRNA(GAU); mRNA 8jdj B 75 2.5 RF00005 URS00029156D4_9606 37992713 0030533 9606 uccucnuunguauaguggngaguauccccgccunucangcgggagannggggnucgnuuccccgacggggagcca <<<<<<<..<<<<........>>>><<<<<<.......>>>>>.>..<<<<<.......>>>>>>>>>>>>.... (((.(((..(((.....[....))).(((((.......)))))....(((((..]....)))))))).))).... Structure of the Human cytoplasmic Ribosome with human tRNA Asp(Q34) and mRNA(GAU); tRNA(Asp) 8jdj C 75 2.5 RF00005 URS00029156D4_9606 37992713 0030533 9606 uccucnuunguauaguggngaguauccccgccunucangcgggagannggggnucgnuuccccgacggggagcca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>....<<<<<.......>>>>>>>>>>>>.... (((((((..(((.....[....))).(((((.......)))))....(((((..]....)))))))))))).... Structure of the Human cytoplasmic Ribosome with human tRNA Asp(Q34) and mRNA(GAU); tRNA(Asp) 8jdj D 3512 2.5 RF02543 URS000291568D_9606 37992713 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagngngaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcgggcggaucuuucccgggggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucgggggcccccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcgcucuccccccugggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccggggggccacgcgcgcgucccgggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccnucuugnaacncggaccaaggagunuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccnanagauggugancuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauagnggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcagacccgacccgccacgcaguuuuauccgguaaagcgaaugauuagaggucuuggngccgaucncaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcngaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaunuuggugguagunnnaaauauucaaacgagaacuuugaaggccgaaguggngaaggguuccaugngaacagnanuugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccnuauccgcagcaggucuncaaggugaacngccucuggnauguuggaacaanguagguaagggaagucggcaagcnggauccguaacuucgggauaaggauuggcucuaagggcugcagccgacuuagaacuggugcggaccaggngaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugccnagugcucugaaugucanagugangaaauucaaugaagcgcggnuaaacggcgggaguancuaugacucucuuaagguagcnaanugccucnucaucuaauuagugangcgcaugaanggaugancgagnuucccacugunccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggnggaaucagcggngaaagaagacccuguugagcuugacncuagucuggcacggugaanagacguuuuuucacugacccggugaggcgggggggcgagcucucgcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacugnggcgguacaccugucaaacgguancgcaggnnuccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucagnacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggangugucagaaaaguuaccacagngauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuungaugucggnucuuccuaucauugugaagcagaauucaccaagcguungaunnuucacccacuaauagggaacgugngcugggnuuagancgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagnuncanacauuugguguaunugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccgguccccccgggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..[[[..<<<<<...<<<<<<<<<<..>>>>>>.>>>>.....>>>>>..<<<<<<<<<<...<<<<<<<<........<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>...>>>>>>>>..>>>>>>>>>>.......<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<......>>>..................................<<<<<<<<..<<<.<....<<<<<<<<.<<<.....<<<<<<<<<<<..<<<<.....<<<<.<<<<<<.<<<...<..>.>>>>>>>>>.>>>>.......>>>>>>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<<<<<<<<<<<<<<<<<...<<..<<<.<<.<<<<......<<<<<<<....>>>>>>>.......>>>>.>>>>>........>>>>>>..>>>>>>>>>>>....................<<<<<..<<<<<<..>>>>>>.<<<<<<.<<<<.<<<<<<<<<<<.<<<<<.<<<<..<...........>...>>>>.>>>>>.>.>>>>>>>.>>>...>>>>>>>>.>>..<<<<<<<..>>>>>.>>.....>>>>>.....>>>.>>>>>....>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<<....>>>>>>>>..<<<<<...<<<..<<<..((((.((((>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<....................<<<.<<<<<<<<<...<<<....<<<..<.<<<<...<<<<....>>>>.>>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.........>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<............>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<..........)))).))))...............>>>>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<...........>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<...<<<<<<<....>>>>>>>...<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..{{{..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<...............>>>>><<.<<<<<<<<<<..>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<...<.<<<<....>>>>.>...>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<<.<<<<<<<<<..>>>>>>>>>...<<<<<.....<<<<......<..>.................<<<<<<<<<<<.....>>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))]......((((((..(((..>>>>>>.)))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>........<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>.....<<<<<<<....>>>.>>>>....}}..}}}.]]]]].....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<.}}}..>>>>..>>.>>...>>>>...>>>><<<<....<<<<<...........>>>>>....>>>>.>>>...>.>>>>>>.....<<<<<<<.<<..<<<<....<<<........<<<<<.<<<<..>>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>..............>>>>..>>>>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<....<<<<<......>>>>>...>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((...((((((((((())))))).)))).....)))....((((((((((...(((.((((........((((((((..({((((......)))))....[[(...).(((....}]])))...).)))))))...))).))))..))))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....(((((((((((..((((((..(((((.((.(((.(((...(..).)))))).)).)))))..).).)))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((.((.((((......(((((((....))))))).......)))).)))))........))))))..)))))))))))....................((((((.((((((())))))).((((((.((((.(((((((((((.((((..((((..................))))..)))).).))))))).)))...)))))))).))..(((((((()))))).))..[.)))))).....))).)))))...)))))...)))))))).<((((........))))((((((....(((((((((((((..(((..(((((........))))..)..)))...((....))...(((((((......)))))))..(((((...(((..(((..[[[[.[[[[)))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((....................(((.((((((((.....((.....((....((((.(.((((....)))))))))....))...))......))))))...(((((((((.(......))))))))))....))))))))))))..))..((((..(.((.....)).)..))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.....{.()...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((..........]]]].]]]]].(...)........)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((..(((((((...((.....)).))))))....[[(((.((...(.....(((....)))..........((.(((((...........))))))).......)....))...(((((........)))))]]((((....(((((...(((((((....)))))))..((((....)))...(...((((((...((((((((((((((((((((((...{{{...)))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).))).))).....((......)).)))).((((.....))))..)))....(((......(((((((.((..(....(.......(((((....(.[..).....)))))((.((((((((((()))))..)))))).))(...).......(((((((((.>.(...........)...(((((((....((((.....))))......))))))).].(.(.(((..((((((.....(......((.(....).))......)..))))..)))))(.(.(.........).).)........((..........(((((.......)))))..)..)....).)....)).))))))).)..))).)))))))...)))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.(((((...(((((.(((((((((.(((((((((())))))))))...(((((.....((((..((.((()))))..............(((((((((((.....)))))))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(..((....((....{..))....)).)(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}.....)))..)))))).......(....(.((((.(...((.......))...).))))...)....)........((((.((((((..(.(.(.(((......))).)...).).(((.(.....).))).....)))))..)...))).)......((((((....))).)))...a.))..))).))))).....(.((.(.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}}.)))))..)).))...))))...)))).((((...((((.....}.......))))...))))..)))...).).)).).....((((((..((..((((.(..(((........(((((.((((..)))).))))).......)))...(((..((((....((((.(((((((......)))))))))))...))))..)))...........)..))))..)).))))))(((((....(.......).......((.(((((((.((.....(.((.(..(((((......)))))..))).)....))....)))).))).))..))))).. Structure of the Human cytoplasmic Ribosome with human tRNA Asp(Q34) and mRNA(GAU); 28S ribosomal RNA 8jdj E 120 2.5 RF00001 URS000002B0D5_9606 37992713 0003735 0005840 9606 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. Structure of the Human cytoplasmic Ribosome with human tRNA Asp(Q34) and mRNA(GAU); 5S ribosomal RNA 8jdj F 156 2.5 RF00002,RF02540 URS00004B2C76_9606 37992713 0003735 0005840 9606 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauuncaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<.<<.....>>>.....(.<<<.(....>>.........)...>>>..)...>>>....<<....>><<<<<<<<<.....>>>>>>>>>.................... .........................................((((((.[[....[)))...].(.(((......]].............)))..)...)))....((....))(((((((((.....))))))))).................... Structure of the Human cytoplasmic Ribosome with human tRNA Asp(Q34) and mRNA(GAU); 5.8S ribosomal RNA 8jdj w 1634 2.5 RF01960,RF02542,RF01959,RF00177 URS0000E60B8A_9606 37992713 0003735 0005840 9606 uaccugguugauccugccaguagcaunugcuugucucaaagauuaagccaugcaugucuaaguacgcacgacagugaaacugcgaauggcucnuuaaaucaguuauggunccuunggucgcucgacuuggauaacugugguanuucuagngcuaananaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucagauggugacucuagauaaccgccgaucgcacgcgcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgaunccggaganggagccugagaaacggcuaccacauncaaggnaggcagcaggcgcgcnaauuacccacucccgacccggggangungugangaaaaauaacaauacaggcccuguaauuggaaugaguccacuuuaanuccuuccgcgaggnuccauuggagngcaagucuggugccagcagccgcggnaauuccagcuccaauancguauauuaaaguugcugcaguunaaaagcucguaguungaucunuuacuuugaaaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagancgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacncaacacgggaaaccucacccggcccggacacggacagganugacagauugauagcucuuucucgauuccguggguggngnugcauggcnguucuuaguugguggagcgauuugucugguuaauuccgauaacgancgagacunuggcaugcuaacuaguuacgcgacccgcggucggcgucccccaacuncuuagagggacaaguggcguucagccacccgagauugagcaauaacangucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgagnaauucccaguaagugcgggucauaagcuugcguugauunagucccugcccuuuguacacaccgnccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgcgcggagcgcugagaagacggucgaacungacuaucuagaggaaguaaaagucguancaagguuucnguaggugnnccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<....>>...>>.>>......<<........<<<.<....<<....<<<<.........<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<<......>>>>>...>>>><<..<<<<<....<......>..>>>>>..>>...<<<<.<<..>>>>>>..>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>..>>>..>...>>.>.....<<.<<<.<..>..>>>..>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<....<<<<<<.<.......<<...<.......>.<<<<.......>>>>...>>......>.>>>..>>>........<.<<.<<<<.<<...............>>.>>>>.>>.>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<...>>>>.>>>>.....>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<...<..>.....>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))((...(.(((......(..((.....(((.(((..((....((....((....))...))[))......(((.......(((.(.(..((....((((....((...((.....((.(((.....))).))......))......)).((((...((((........))))...)))).(..(((((....(......)..)))))..)..(.((((.((()))))))).).)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((.....((.]....))..)))).)...)........(...((.(())..))....)....(.(...(...........)...)......)..(((((.[......(.((.....((..].)).......)).).)))))..))).)...))..[......(.([[...(.(.((...(.(..(....(..(((..........(..((.......)).(((.......)))....).........)))....)........(.((.(....((...............))....).)).)....)....(((.((...(...(((...((..((((((((...(..........)......))))))))..)).......((....))....)))..)...))..))..)).)...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.(((((....))))))))))).)..)))...((..]]))...))...].))))).).(((......((.(....).))....)))...]]].]((.(..(((((((..((..((.((..(((..(((((.......(........)...........(((((.(....(((((.....(..((..((........))..))....).)))))...((.(((...(.((((((.(..((..(((((....)))..(.((......)))...))..))....(((...(...((.(..((((((((((((...)))).)))).....))))..).))..).....(((((.....)))))........))).)..))).))).....).))))).....).)))))...)).)))..))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....((((............)))).....)..)..)).)).....((((((((.......))))))))......))...))))))).)..))..(.(..((.(..((((.((..(.((((((((.(((..((((.((...(((((((((..))).).)))))...)).))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}........ Structure of the Human cytoplasmic Ribosome with human tRNA Asp(Q34) and mRNA(GAU); 18S ribosomal RNA 8jdk A 14 2.26 37992713 9606 ugaugaugaugaug .............. .............. Structure of the Human cytoplasmic Ribosome with human tRNA Asp(ManQ34) and mRNA(GAU); mRNA 8jdk B 75 2.26 RF00005 URS00029156D4_9606 37992713 0030533 9606 uccucnuunguauaguggngaguauccccgccunucangcgggagannggggnucgnuuccccgacggggagcca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>....<<<<<.......>>>>>>>>>>>>.... (((((((..(((.....[....))).(((((.......)))))....(((((..]....)))))))))))).... Structure of the Human cytoplasmic Ribosome with human tRNA Asp(ManQ34) and mRNA(GAU); tRNA (Asp) 8jdk C 75 2.26 RF00005 URS00029156D4_9606 37992713 0030533 9606 uccucnuunguauaguggngaguauccccgccunucangcgggagannggggnucgnuuccccgacggggagcca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>....<<<<<.......>>>>>>>>>>>>.... (((((((..(((.....[....))).(((((.......)))))....(((((..]....)))))))))))).... Structure of the Human cytoplasmic Ribosome with human tRNA Asp(ManQ34) and mRNA(GAU); tRNA (Asp) 8jdk D 3512 2.26 RF02543 URS000291568D_9606 37992713 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagngngaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcgggcggaucuuucccgggggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucgggggcccccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcgcucuccccccugggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccggggggccacgcgcgcgucccgggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccnucuugnaacncggaccaaggagunuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccnanagauggugancuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauagnggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcagacccgacccgccacgcaguuuuauccgguaaagcgaaugauuagaggucuuggngccgaucncaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcngaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaunuuggugguagunnnaaauauucaaacgagaacuuugaaggccgaaguggngaaggguuccaugngaacagnanuugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccnuauccgcagcaggucuncaaggugaacngccucuggnauguuggaacaanguagguaagggaagucggcaagcnggauccguaacuucgggauaaggauuggcucuaagggcugcagccgacuuagaacuggugcggaccaggngaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugccnagugcucugaaugucanagugangaaauucaaugaagcgcggnuaaacggcgggaguancuaugacucucuuaagguagcnaanugccucnucaucuaauuagugangcgcaugaanggaugancgagnuucccacugunccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggnggaaucagcggngaaagaagacccuguugagcuugacncuagucuggcacggugaanagacguuuuuucacugacccggugaggcgggggggcgagcucucgcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacugnggcgguacaccugucaaacgguancgcaggnnuccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucagnacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggangugucagaaaaguuaccacagngauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuungaugucggnucuuccuaucauugugaagcagaauucaccaagcguungaunnuucacccacuaauagggaacgugngcugggnuuagancgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagnuncanacauuugguguaunugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccgguccccccgggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..[[[..<<<<<...<<<<<<<<<<..>>>>>>.>>>>.....>>>>>..<<<<<<<<<<...<<<<<<<<........<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>...>>>>>>>>..>>>>>>>>>>.......<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<.<....<<<<<<<<.<<<.....<<<<<<<<<<<..<<<<.<...<<<<.<<<<<<.<<<...<..>.>>>>>>>>>.>>>>...>...>>>>>>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<<<<<<<<<<<<<<<<<...<<..<<<.<<.<<<<......<<<<<<<....>>>>>>>.......>>>>.>>>>>........>>>>>>..>>>>>>>>>>>....................<<<<<..<<<<<<..>>>>>>.<<<<<<.<<<<.<<<<<<<<<<<.<<<<<.<<<...<...........>....>>>.>>>>>.>.>>>>>>>.>>>...>>>>>>>>.>>..<<<<<<<..>>>>>.>>.....>>>>>.....>>>.>>>>>....>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<<....>>>>>>>>..<<<<<...<<<..<<<..((((.((((>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<....................<<<.<<<<<<<<<...<<<....<<<..<.<<<<...<<<<....>>>>.>>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.........>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<............>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<..........)))).))))...............>>>>>>>>>....>>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<...........>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<..<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..{{{..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<..>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<...<.<<<<....>>>>.>...>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<<.<<<<<<<<<..>>>>>>>>>...<<<<<.....<<<<......<..>.................<<<<<<<<<<<.....>>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>><<<<....>>>>>>)))]......((((((..(((..>>>>>>.)))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>........<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>.....<<<<<<<....>>>.>>>>....}}..}}}.]]]]].....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<.}}}..>>>>..>>.>>...>>>>...>>>><<<<....<<<<<...........>>>>>....>>>>.>>>...>.>>>>>>.....<<<<<<<.<<..<<<<....<<<........<<<<<.<<<<..>>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>..............>>>>..>>>>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<....<<<<<......>>>>>...>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((...((((((((((())))))).)))).....)))....((((((((((...(((.((((...(....((((((((..({((((......)))))....[[(...).(((....}]])))...).))))))))..))).))))..))))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....(((((((((((..((((((..(((((.((.(((.(((...(..).)))))).)).)))))..).).)))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((.((.((((......(((((((....))))))).......)))).)))))........))))))..)))))))))))....................((((((.((((.(()).)))).((((((.((((.(((((((((((.((((..((((..................))))..)))).).))))))).)))...)))))))).))..(((((((()))))).))..[.)))))).....))).)))))...)))))...)))))))).<((((........))))((((((....(((((((((((((..(((..(((((........))))..)..)))...((....))...(((((((......)))))))..(((((...(((..(((..[[[[.[[[[)))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((....................(((.((((((((.....((.....((....((((.(.((((....)))))))))....))...))......))))))...(((((((((.(......))))))))))....))))))))))))..))..((((..(.((.....)).)..))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.....{.()...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((..........]]]].]]]]].(...)........)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((..(((((((...((.....)).))))))....[[(((.((...(.....(((....)))..........((.(((((...........))))))).......)....))...(((((........)))))]]((((....(((((...(((((((....)))))))..((((....)))...(...((((((...((((((((((((((((((((((...{{{...)))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....(((((((.......))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).))).))).....((......)).)))).((((.....))))..)))....(((......(((((((.((..(....(.......(((((....(.[..).....)))))((.((((((((((()))))..)))))).))(...).......(((((((((.>.(...........)...(((((((....((((.....))))......))))))).].(.(.(((..((((((.....(......((.(....).))......)..))))..)))))(.(.(.........).).)........((..........(((((.......)))))..)..)....).)....)).))))))).)..))).)))))))...)))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.(((((...(((((.(((((((((.(((((((((())))))))))...(((((.....((((..((..(()).))..............(((((((((((.....)))))))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(..((....((....{..))....)).)(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}.....)))..)))))).......(....(.((((.(...((.......))...).))))...)....)........((((.((((((..(.(.(.(((......))).)...).).(((.(.....).))).....)))))..)...))).)......((((((....))).)))...a.))..))).))))).....(.((.(.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}}.)))))..)).))...))))...)))).((((...((((.....}.......))))...))))..)))...).).)).).....((((((..((..((((.(..(((........(((((.((((..)))).))))).......)))...(((..((((....((((.(((((((......)))))))))))...))))..)))...........)..))))..)).))))))(((((....(.......).......((.(((((((.((.....(.((.(..(((((......)))))..))).)....))....)))).))).))..))))).. Structure of the Human cytoplasmic Ribosome with human tRNA Asp(ManQ34) and mRNA(GAU); 28S ribosomal RNA 8jdk E 120 2.26 RF00001 URS000002B0D5_9606 37992713 0003735 0005840 9606 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. Structure of the Human cytoplasmic Ribosome with human tRNA Asp(ManQ34) and mRNA(GAU); 5S ribosomal RNA 8jdk F 156 2.26 RF00002,RF02540 URS00004B2C76_9606 37992713 0003735 0005840 9606 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauuncaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<.<<.....>>>.....(.<<<.(....>>.........)...>>>..)...>>>....<<....>><<<<<<<<<.....>>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))(((((((((.....))))))))).................... Structure of the Human cytoplasmic Ribosome with human tRNA Asp(ManQ34) and mRNA(GAU); 5.8S ribosomal RNA 8jdk w 1634 2.26 RF01960,RF02542,RF01959,RF00177 URS0000E60B8A_9606 37992713 0003735 0005840 9606 uaccugguugauccugccaguagcaunugcuugucucaaagauuaagccaugcaugucuaaguacgcacgacagugaaacugcgaauggcucnuuaaaucaguuauggunccuunggucgcucgacuuggauaacugugguanuucuagngcuaananaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucagauggugacucuagauaaccgccgaucgcacgcgcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgaunccggaganggagccugagaaacggcuaccacauncaaggnaggcagcaggcgcgcnaauuacccacucccgacccggggangungugangaaaaauaacaauacaggcccuguaauuggaaugaguccacuuuaanuccuuccgcgaggnuccauuggagngcaagucuggugccagcagccgcggnaauuccagcuccaauancguauauuaaaguugcugcaguunaaaagcucguaguungaucunuuacuuugaaaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagancgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacncaacacgggaaaccucacccggcccggacacggacagganugacagauugauagcucuuucucgauuccguggguggngnugcauggcnguucuuaguugguggagcgauuugucugguuaauuccgauaacgancgagacunuggcaugcuaacuaguuacgcgacccgcggucggcgucccccaacuncuuagagggacaaguggcguucagccacccgagauugagcaauaacangucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgagnaauucccaguaagugcgggucauaagcuugcguugauunagucccugcccuuuguacacaccgnccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgcgcggagcgcugagaagacggucgaacungacuaucuagaggaaguaaaagucguancaagguuucnguaggugnnccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<....>>...>>.>>......<<........<<<.<....<<....<<<<.........<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<<......>>>>>...>>>><<..<<<<<....<......>..>>>>>..>>...<<<<.<<..>>>>>>..>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<.......>>..>>>..>...>>.>.....<<.<<<.<..>..>>>..>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<....<<<<<<.<.......<<...<.......>.<<<<.......>>>>...>>......>.>>>..>>>........<.<<.<<<<.<<...............>>.>>>>.>>.>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<<.......<<.<<<........>>>.>>.....>>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<...>>>>.>>>>.....>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>>....>.>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<...<..>.....>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))((...(.(((......(..((.....(((.(((..((....((....((....))...))[))......(((.......(((.(.(..((....((((....((...((.....((.(((.....))).))......))......)).((((...((((........))))...)))).(..(((((....(......)..)))))..)..(.((((.((()))))))).).)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((.....((.]....))..)))).)...)........(...((.(())..))....)....(.((.................))......)..((((..[......(.((.....((..].)).......)).)..))))..))).)...))..[......(.([[...(.(.((...(.(..(....(..(((.............((.......)).(((.......)))..............)))....)........(.((.(.(..((...............))...)).)).)....)....(((..(...(...(((...((..((((((((...(..........)......))))))))..)).......((....))....)))..)...)...))..)).)...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.(((((....))))))))))).)..)))...((..]]))...))...].))))).).(((......((.(....).))....)))...]]].]((.(..(((((((..((..((.((..(((..(((((.......(........)...........(((((.(....(((((.....(..((..((........))..))....).)))))...((.(((...(.((((((....((..(((((....)))..(.((......)))...))..))....(((...(...((.(..((((((((((((...)))).)))).....))))..).))..).....(((((.....)))))........)))....))).))).....).))))).....).)))))...)).)))..))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....((((............)))).....)..)..)).)).....((.(((((.......))))).))......))...))))))).)..))..(.(..((.(..((((.((..(.((((((((.(((..((((.((...((((((.((..))..).)))))...)).))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}........ Structure of the Human cytoplasmic Ribosome with human tRNA Asp(ManQ34) and mRNA(GAU); 18S ribosomal RNA 8jdl A 11 2.42 37992713 9606 uuauuauuauu ........... ........... Structure of the Human cytoplasmic Ribosome with human tRNA Tyr(GalQ34) and mRNA(UAU) (non-rotated state); mRNA 8jdl B 76 2.42 URS00029156DE_9606 37992713 9606 ccuucnauancucagnnggnagagcnnaggacunuananccuuagnnngcuggnucgnuuccggcucgaaggacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((.........)))).....(((((..]....)))))))))))).... Structure of the Human cytoplasmic Ribosome with human tRNA Tyr(GalQ34) and mRNA(UAU) (non-rotated state); tRNA (Tyr) 8jdl D 3512 2.42 RF02543 URS000291568D_9606 37992713 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagngngaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcgggcggaucuuucccgggggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucgggggcccccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcgcucuccccccugggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccggggggccacgcgcgcgucccgggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccnucuugnaacncggaccaaggagunuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccnanagauggugancuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauagnggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcagacccgacccgccacgcaguuuuauccgguaaagcgaaugauuagaggucuuggngccgaucncaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcngaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaunuuggugguagunnnaaauauucaaacgagaacuuugaaggccgaaguggngaaggguuccaugngaacagnanuugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccnuauccgcagcaggucuncaaggugaacngccucuggnauguuggaacaanguagguaagggaagucggcaagcnggauccguaacuucgggauaaggauuggcucuaagggcugcagccgacuuagaacuggugcggaccaggngaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugccnagugcucugaaugucanagugangaaauucaaugaagcgcggnuaaacggcgggaguancuaugacucucuuaagguagcnaanugccucnucaucuaauuagugangcgcaugaanggaugancgagnuucccacugunccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggnggaaucagcggngaaagaagacccuguugagcuugacncuagucuggcacggugaanagacguuuuuucacugacccggugaggcgggggggcgagcucucgcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacugnggcgguacaccugucaaacgguancgcaggnnuccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucagnacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggangugucagaaaaguuaccacagngauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuungaugucggnucuuccuaucauugugaagcagaauucaccaagcguungaunnuucacccacuaauagggaacgugngcugggnuuagancgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagnuncanacauuugguguaunugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccgguccccccgggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..[[[...<<<<...<<<<<<<<<<..>>>>>>.>>>>.....>>>>...<<<<<<<<<<...<<<<<<<<........<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>...>>>>>>>>..>>>>>>>>>>.......<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<......>>>..................................<<<<<<<<..<<<.<....<<<<<<<<.<<<.....<<<<<<<<<<<..<<<<.<..<<<<<.<<<<<<.<<<...<..>.>>>>>>>>>.>>>>>..>...>>>>>>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<<<<<<<<<<<<<<<<<...<<..<<<.<<.<<<<......<<<<<<<....>>>>>>>.......>>>>.>>>>>........>>>>>>..>>>>>>>>>>>....................<<<<<..<<<<<<..>>>>>>.<<<<<<.<<<<.<<<<<<<<<<<.<<<<..<<<<..<...........>...>>>>..>>>>.>.>>>>>>>.>>>...>>>>>>>>.>>..<<<<<<<..>>>>>.>>.....>>>>>.....>>>.>>>>>....>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<<....>>>>>>>>..<<<<<...<<<..<<<..((((.((((>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<....................<<<.<<<<<<<<<...<<<....<<<..<.<<<<...<<<<....>>>>.>>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.........>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<............>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<..........)))).))))...............>>>>>>>>>....>>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<...........>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<..<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..{{{..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<.<<<<<<<<<<..>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<...<.<<<<....>>>>.>...>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<<.<<<<<<<<<..>>>>>>>>>...<<<<<.....<<<<..<<.<<..>>>>..............<<<<<<<<<<<.....>>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>><<<<....>>>>>>)))]......((((((..(((..>>>>>>.)))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>........<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>.....<<<<<<<....>>>.>>>>....}}..}}}.]]]]].....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<}}}.>>>>>..>>.>>...>>>>...>>>><<<<....<<<<<...........>>>>>....>>>>.>>>...>.>>>>>>.....<<<<<<<.<<..<<<<....<<<........<<<<<.<<<<..>>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>..............>>>>..>>>>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<....<<<<<......>>>>>...>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((...((((((((((())))))).)))).....)))....((((((((((...(((.((((........((((((((..({((((......)))))....[[(...).(((....}]])))...).)))))))...))).))))..))))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((..(...((((((((.(((.....(((((((((((..((((((..(((((.((.(((.(((...(..).)))))).)).)))))..).).)))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((.((.((((......(((((((....))))))).......)))).)))))........))))))..)))))))))))....................((((((.((((((..)))))).((((((.((((.((((((((((..((((..((((..................))))..))))...))))))).)))...)))))))).))..(((((((()))))).))..[.)))))).....))).)))))...).)))...)))))))).<((((........))))((((((....(((((((((((((..(((..(((((........))))..)..)))...((....))...((((.(((....)).)))))..(((((...(((..(((..[[[[.[[[[)))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((....................(((.((((((((.....((.....((....((((.(.(((......))))))))....))...))......))))))...(((((((((.(......))))))))))....))))))))))))..))..((((..(.((.....)).)..))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.....{.()...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((..........]]]].]]]]].(...)........)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((..(((((((...((.....)).))))))....[[(((.((...(.....(((....)))..........((.(((((...........))))))).......)....))...(((((........)))))]]((((....(((((...((.((((....)))).))..((((....)))...(...((((((...((((((((((((((((((((((...{{{...)))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).))).))).....((......)).)))).((((.....))))..)))....(((......(((((((.((..(....(.......(((((....(.[..).....)))))((.((((((((((()))))..)))))).))(...).......(((((((((.>.(...........)...(((((((....((((.....))))......))))))).].(.(.(((..((((((.....(......((.(....).))......)..))))..)))))(.(.(.........).).)........((..........(((((.......)))))..)..)....).)....)).))))))).)..))).)))))))...)))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.(((((...(((((.(((((((((.(((((((((())))))))))...(((((.....((((..(..((())).)..............(((((((((((.....)))))))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(..((....((....{..))....)).)(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}.....)))..)))))).......(....(.((((.(...((.......))...).))))...)....)........((((.((((((..(.(.(.(((......))).)...).).(((.(.....).))).....)))))..)...))).)......((((((....))).)))...a.))..))).))))).....(.((.(.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}}.)))))..)).))...))))...)))).((((...((((.....}.......))))...))))..)))...).).)).).....((((((..((..((((.(..(((........(((((.((((..)))).))))).......)))...(((..((((....((((.(((((((......)))))))))))...))))..)))...........)..))))..)).))))))(((((....(.......).......((.(((((((.((.....(.((.(..(((((......)))))..))).)....))....)))).))).))..))))).. Structure of the Human cytoplasmic Ribosome with human tRNA Tyr(GalQ34) and mRNA(UAU) (non-rotated state); 28S ribosomal RNA 8jdl E 120 2.42 RF00001 URS000002B0D5_9606 37992713 0003735 0005840 9606 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. Structure of the Human cytoplasmic Ribosome with human tRNA Tyr(GalQ34) and mRNA(UAU) (non-rotated state); 5S ribosomal RNA 8jdl F 156 2.42 RF00002,RF02540 URS00004B2C76_9606 37992713 0003735 0005840 9606 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauuncaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<.<<.....>>>.....(.<<<.(....>>.........)...>>>..)...>>>....<<....>><<<<<<<<<.....>>>>>>>>>.................... .........................................((((((.[[....[)))...].(.(((......]].....(...)...)))..)...)))....((....))(((((((((.....))))))))).................... Structure of the Human cytoplasmic Ribosome with human tRNA Tyr(GalQ34) and mRNA(UAU) (non-rotated state); 5.8S ribosomal RNA 8jdl w 1634 2.42 RF01960,RF02542,RF01959,RF00177 URS0000E60B8A_9606 37992713 0003735 0005840 9606 uaccugguugauccugccaguagcaunugcuugucucaaagauuaagccaugcaugucuaaguacgcacgacagugaaacugcgaauggcucnuuaaaucaguuauggunccuunggucgcucgacuuggauaacugugguanuucuagngcuaananaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucagauggugacucuagauaaccgccgaucgcacgcgcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgaunccggaganggagccugagaaacggcuaccacauncaaggnaggcagcaggcgcgcnaauuacccacucccgacccggggangungugangaaaaauaacaauacaggcccuguaauuggaaugaguccacuuuaanuccuuccgcgaggnuccauuggagngcaagucuggugccagcagccgcggnaauuccagcuccaauancguauauuaaaguugcugcaguunaaaagcucguaguungaucunuuacuuugaaaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagancgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacncaacacgggaaaccucacccggcccggacacggacagganugacagauugauagcucuuucucgauuccguggguggngnugcauggcnguucuuaguugguggagcgauuugucugguuaauuccgauaacgancgagacunuggcaugcuaacuaguuacgcgacccgcggucggcgucccccaacuncuuagagggacaaguggcguucagccacccgagauugagcaauaacangucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgagnaauucccaguaagugcgggucauaagcuugcguugauunagucccugcccuuuguacacaccgnccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgcgcggagcgcugagaagacggucgaacungacuaucuagaggaaguaaaagucguancaagguuucnguaggugnnccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<....>>...>>.>>......<<........<<<.<....<<....<<<<<........<<.....<<.<<.......>>.>>......>>.........<<<<...<<<<........>>>>...>>>><<..<<<<<....<......>..>>>>>..>>...<<<<.<<..>>>>>>.>>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<.......>>..>>>..>...>>.>.....<<.<<<.<..>..>>>..>>......<<..<...........>..>>........<<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>>.>>>>>>.>>>.........<.<((.....<.<<...<<<.<<....<<<<<<.<.......<<...<.......>.<<<<.......>>>>...>>......>.>>>..>>>........<.<<.<<<<.<<...............>>.>>>>.>>.>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<<....>>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<<.......<<.<<<........>>>.>>.....>>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<...>>>>.>>>>.....>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>>....>.>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<.<.<..>.>...>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))((...(.(((......(..((.....(((.(((..((....((....((....))...))[))......(((.......(((.(.(..((....(((.....((...(......((.(.(.....).).)).......)......)).((((...((((........))))...)))).(..(((((....(......)..)))))..)..(.((((.((())))))))...)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((....(.(.]....))..)))).)...)........(...((.(())..))....)....(.(...(...........)...)......)..(((((.[......(.((.....((..].)).......)).).)))))..))).)...))..[......(.([[...(.(.((...(.(..(....(..(((..........(..(.........).(((.......)))....).........)))....)........(.((.(.(..((...............))...)).)).)....)....(((.((...(...(((...(((.((((((((...(..........)......)))))))).))).......((....))....)))..)...))..))..)).)...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.(((((....))))))))))).)..)))...((..]]))...))...].))))).).(((......((.(....).))....)))...]]].]((.(..(((((((..((..((.((..(((..(((((.......(........)...........(((((.(....(((((.....(..((..((........))..))....).)))))...((.(((...(.((((((....((..(((((....)))..(.((......)))...))..))....(((...(...((.(..((((((((((((...)))).)))).....))))..).))..).....(((((.....)))))........)))....))).))).....).))))).....).)))))...)).)))..))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....((((............)))).....)..)..)).)).....((((((((.......))))))))......))...))))))).)..))..(.(..((.(..((((.((..(.((((((((.(((..((((.((...((.(((.((()))..).)).))...)).))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}........ Structure of the Human cytoplasmic Ribosome with human tRNA Tyr(GalQ34) and mRNA(UAU) (non-rotated state); 18S ribosomal RNA 8jdm A 14 2.67 37992713 9606 uuauuauuauuauu .............. .............. Structure of the Human cytoplasmic Ribosome with human tRNA Tyr(GalQ34) and mRNA(UAU) (rotated state); mRNA 8jdm B 73 2.67 URS00029156DE_9606 37992713 9606 ccuucnauancucagggagagcnnaggacunuananccuuagnnngcuggnucgnuuccggcucgaaggacca <<<<<<<..<<<<.....>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... ((((.((..((((...[.)))).((((.........)))).....(((((..]....))))))).)))).... Structure of the Human cytoplasmic Ribosome with human tRNA Tyr(GalQ34) and mRNA(UAU) (rotated state); tRNA (Tyr) 8jdm C 73 2.67 URS00029156DE_9606 37992713 9606 ccuucnauancucagggagagcnnaggacunuananccuuagnnngcuggnucgnuuccggcucgaaggacca <<<<<<<..<<<<.....>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..(((....[..))).((((.........)))).....(((((..]....)))))))))))).... Structure of the Human cytoplasmic Ribosome with human tRNA Tyr(GalQ34) and mRNA(UAU) (rotated state); tRNA (Tyr) 8jdm D 3512 2.67 RF02543 URS000291568D_9606 37992713 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagngngaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcgggcggaucuuucccgggggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucgggggcccccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcgcucuccccccugggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccggggggccacgcgcgcgucccgggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccnucuugnaacncggaccaaggagunuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccnanagauggugancuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauagnggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcagacccgacccgccacgcaguuuuauccgguaaagcgaaugauuagaggucuuggngccgaucncaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcngaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaunuuggugguagunnnaaauauucaaacgagaacuuugaaggccgaaguggngaaggguuccaugngaacagnanuugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccnuauccgcagcaggucuncaaggugaacngccucuggnauguuggaacaanguagguaagggaagucggcaagcnggauccguaacuucgggauaaggauuggcucuaagggcugcagccgacuuagaacuggugcggaccaggngaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugccnagugcucugaaugucanagugangaaauucaaugaagcgcggnuaaacggcgggaguancuaugacucucuuaagguagcnaanugccucnucaucuaauuagugangcgcaugaanggaugancgagnuucccacugunccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggnggaaucagcggngaaagaagacccuguugagcuugacncuagucuggcacggugaanagacguuuuuucacugacccggugaggcgggggggcgagcucucgcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacugnggcgguacaccugucaaacgguancgcaggnnuccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucagnacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggangugucagaaaaguuaccacagngauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuungaugucggnucuuccuaucauugugaagcagaauucaccaagcguungaunnuucacccacuaauagggaacgugngcugggnuuagancgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagnuncanacauuugguguaunugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccgguccccccgggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..[[[..<<<<<...<<<<<<<<<<..>>>>>>.>>>>.....>>>>>..<<<<<<<<<....<<<<.<<<........<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>...>>>.>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<......>>>..................................<<<<<<<<..<<<.<....<<<<<<<<.<<<.....<<<<<<<<<<<..<<<<.<...<<<<.<<<<<<.<<<...<..>.>>>>>>>>>.>>>>...>...>>>>>>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<<<<<<<<<<<<<<<<<...<<..<<<.<<.<<<<......<<<<<<<<..>>>>>>>>.......>>>>.>>>>>........>>>>>>..>>>>>>>>>>>....................<<<<<..<<<<<<..>>>>>>.<<<<<<.<<<<.<<<<<<<<<<<.<<<<..<<<<..<...........>...>>>>..>>>>.>.>>>>>>>.>>>...>>>>>>>>.>>..<<<<<<<..>>>>>.>>.....>>>>>.....>>>.>>>>>....>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<<....>>>>>>>>..<<<<<...<<<..<<<..((((.((((>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<....................<<<.<<<<<<<<<...<<<....<<<..<.<<<<...<<<<....>>>>.>>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.........>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<............>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<..........)))).))))...............>>>>>>>>>....>>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<..<.....>..>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<..<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..{{{..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<..>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<<.<<<<<<<<<..>>>>>>>>>...<<<<<.....<<<<...<.<<..>>>...............<<<<<<<<<<<.....>>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>>.<<<....>>>.>>)))]......((((((..(((..>>>>>>.)))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>........<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>.....<<<<<<<....>>>.>>>>....}}..}}}.]]]]].....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<.}}}..>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.....<<<<<<<.<<..<<<<....<<<........<<<<<.<<<<..>>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>..............>>>>..>>>>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<....<<<<<......>>>>>...>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((...((((((((((())))))).)))).....)))....((((((((((...(((.((((........((((((((..({((((......)))))....[[(...).(((....}]])))...).)))))))...))).))))..))))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....(((((((((((..((((((..(((((..(.(((.(((....(.).)))))).)..)))))..).).)))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((.((.((((......(((((((....))))))).......)))).)))))........))))))..)))))))))))....................((((((.((((((())))))).((((((.((((.(((((((((((.((((..((((..................))))..)))).).))))))).)))...)))))))).))..(((((((()))))).))..[.)))))).....))).)))))...)))))...)))))))).<((((........))))((((((....(((((((((((((..(((..(((((........))))..)..)))...((....))...((((.(((....)).)))))..(((((...(((..(((..[[[[.[[[[)))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((....................(((.((((((((.....((.....((....((((.(.((((....)))))))))....))...))......))))))...(((((((((.(......))))))))))....))))))))))))..))..((((..(.((.....)).)..))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.....{.()...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((..........]]]].]]]]].(...)........)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((..(((((((...((.....)).))))))....[[(((.((...(.....(((....)))..........((.((((((.........)))))))).......)....))...(((((........)))))]]((((....(((((...(((((((....)))))))..((((....)))...(...((((((...((((((((((((((((((((((...{{{...)))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).))).))).....((......)).)))).((((.....))))..)))....(((......(((((((.((..(....(.......(((((....(.[..).....)))))((.((((((((((()))))..)))))).))(...).......(((((((((.>.(...........)...(((((((....((((.....))))......))))))).].(.(.(((..((((((.....(......((.(....).))......)..))))..)))))(.(.(.........).).)........((..........(((((.......)))))..)..)....).)....)).))))))).)..))).)))))))...)))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.(((((...(((((.(((((((((.(((((((((())))))))))...(((((.....((((..((.((()))))..............(((((((((((.....)))))))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(..((....((....{..))....)).)(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}.....)))..)))))).......(....(.((((.(...((.......))...).))))...)....)........((((.((((((..(.(.(.(((......))).)...).).(((.(.....).))).....)))))..)...))).)......((((((....))).)))...a.))..))).))))).....(.((.(.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}}.)))))..)).))...))))...)))).((((...((((.....}.......))))...))))..)))...).).)).).....(((((((.((..((((.(..(((........(((((.((((..)))).))))).......)))...(((...(((....((((.(((((((......)))))))))))...)))...)))...........)..))))..)))))))))(((((....(.......).......((.(((((((.((.....(.((.(..(((((......)))))..))).)....))....)))).))).))..))))).. Structure of the Human cytoplasmic Ribosome with human tRNA Tyr(GalQ34) and mRNA(UAU) (rotated state); 28S ribosomal RNA 8jdm E 120 2.67 RF00001 URS000002B0D5_9606 37992713 0003735 0005840 9606 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. Structure of the Human cytoplasmic Ribosome with human tRNA Tyr(GalQ34) and mRNA(UAU) (rotated state); 5S ribosomal RNA 8jdm F 156 2.67 RF00002,RF02540 URS00004B2C76_9606 37992713 0003735 0005840 9606 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauuncaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<.<<.....>>>.....(.<<<.(....>>.........)...>>>..)...>>>....<<....>><<<<<<<<<.....>>>>>>>>>.................... .........................................((((((.[[....[)))...].(.(((......]].....(...)...)))..)...)))....((....))(((((((((.....))))))))).................... Structure of the Human cytoplasmic Ribosome with human tRNA Tyr(GalQ34) and mRNA(UAU) (rotated state); 5.8S ribosomal RNA 8jdm w 1634 2.67 RF01960,RF02542,RF01959,RF00177 URS0000E60B8A_9606 37992713 0003735 0005840 9606 uaccugguugauccugccaguagcaunugcuugucucaaagauuaagccaugcaugucuaaguacgcacgacagugaaacugcgaauggcucnuuaaaucaguuauggunccuunggucgcucgacuuggauaacugugguanuucuagngcuaananaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucagauggugacucuagauaaccgccgaucgcacgcgcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgaunccggaganggagccugagaaacggcuaccacauncaaggnaggcagcaggcgcgcnaauuacccacucccgacccggggangungugangaaaaauaacaauacaggcccuguaauuggaaugaguccacuuuaanuccuuccgcgaggnuccauuggagngcaagucuggugccagcagccgcggnaauuccagcuccaauancguauauuaaaguugcugcaguunaaaagcucguaguungaucunuuacuuugaaaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagancgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacncaacacgggaaaccucacccggcccggacacggacagganugacagauugauagcucuuucucgauuccguggguggngnugcauggcnguucuuaguugguggagcgauuugucugguuaauuccgauaacgancgagacunuggcaugcuaacuaguuacgcgacccgcggucggcgucccccaacuncuuagagggacaaguggcguucagccacccgagauugagcaauaacangucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgagnaauucccaguaagugcgggucauaagcuugcguugauunagucccugcccuuuguacacaccgnccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgcgcggagcgcugagaagacggucgaacungacuaucuagaggaaguaaaagucguancaagguuucnguaggugnnccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<....>>...>>.>>......<<........<<<.<....<<....<<<..........<<....<<<.<<<.....>>>.>>.>....>>.........<<<<...<<<<........>>>>...>>>><<..<<<<<....<......>..>>>>>..>>...<<<<.<<..>>>>>>....>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>..>>>..>...>>.>.....<<.<<<.<..>..>>>..>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<....<<<<<<.<.......<<...<.......>.<<<<.......>>>>...>>......>.>>>..>>>........<.<<.<<<<.<<...............>>.>>>>.>>.>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<<....>>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<...>>>>.>>>>.....>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>............<<<<<..........>>>>>...........>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<...<..>.....>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))((...(((((......(..((.....(((.(((..((....((....((....))...))[))......(((.......(((.(.(..((....(((.....((...((.....((.(((.....))).))......))......)).((((...((((........))))...)))).(..(((((....(......)..)))))..)..(.((((.((())))))))...)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((....(((.]...)))..)))).)...)........(...((.(())..))....)....(.(...(...........)...)......)..((((([[......(.((.....((..]])).......)).).)))))..)))))...))..[......(.([[...(.(.((...(.(..(....(..(((.(........(..((.......)).(((.......)))....).......).)))....)........(.((.(.(..((...............))...)).)).)....)....(((.((...(...(((...((..((((((((...(..........)......))))))))..)).......((....))....)))..)...))..))..)).)...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.(((((....))))))))))).)..)))...((..]]))...))...].))))).).(((......((.(....).))....)))...]]].]((.(..(((((((..((..((.((..(((..(((((.......(........)...........(((((.(....(((((.....(..((..((........))..))....).)))))...((.(((...(.((((((....((..(((((....)))..(.((......)))...))..))....(((...(...((.(..((((((((((((...)))).)))).....))))..).))..).....(((((.....)))))........)))....))).))).....).))))).....).)))))...)).)))..))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....((((............)))).....)..)..)).)).....((((((((.......))))))))......))...))))))).)..))..(.(..((.(..((((.((..(.((((((((.(((..((((.((...((((((.((()))..).)))))...)).))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}........ Structure of the Human cytoplasmic Ribosome with human tRNA Tyr(GalQ34) and mRNA(UAU) (rotated state); 18S ribosomal RNA 8jiv Aa 2863 2.84 RF02543 38458197 0003735 0005840 4565 gcgaccccaggucaggcgggacuacccgcugaguuuaagcauauaaanaagcggaggagaagaaacuuacaaggauuccccuaguaacggcgagcgaaccgggagcagcccagcuugagaaucgggcggcugugccguccgaanuguagucuggagaggcguccugcgacggaccgggcccaaguccccuggaaaggggcgccugggagggugagagccccguccggcccggacccugucgcgaggcgccucaacgagucggguuguuugggaaugcagcccaaaucgggcgguagacuccguccaaggcuaaauacaggcgagagaccgauagcgaacaaguaccgcgagggaaagaugnaaaggacuuugaaaagagagucaaaagugcuugaaauugccgggagggaagcggaugggggccggcgaugcgccccggccguaugcggaacggcugguccgccgcucggcucgggguguggacuguugucggccgcgccggcggccaaagcccgggggcccuaggugcccccgguggccgucgucggcacggccgcgcgccuaaaggcgugucccucggggcacugcgcugcaacggccugcgggcuccccauccgacccgucuugnaacncggaccaaggagunngacaugcgugcgagucgacggguucugaaaccugggaugcgcaaggaagcugacgagcgggaggcccugggccgcaccgcuggccgacccugaucuucugugaaggguucgaguuggagcacgccngucgggacccnanagauggugancuaugccugagcggggcgaagccagaggcucugguggaggcucgaagcgauacugncgugcaaaucguucgucugacuuggguauagnggcgaaagacuaaucgaaccaucuagungcugguucccuccgaaguuucccucaggauagcuggagcccaacgaguucuaucagguaaagccaaugauuagaggccuauucucaaacuuuaaanagguaggauggcgcggcugcuucggugagccgugccauggaaucgggcuccaagugggccauuuuugguaagcngaacuggcgaugcgggaugaaccggaagccggguuacggugcccaacugcgcgcuaaccuagaacccacaaaggguguuggucgaacuagccccgaaaauggauggcgcugaagcgcgcgacccacacccggccaucugggcgagcgccaugccccgaugnguaggagggcgcggcggccgcugcaaaacccggggcgcgagcccgggcggagcggccgucggugcagaunuuggugguagunncaaauauucaaaugagaanuuugaaggccgaagaggagaaagguuccaugugaacggnacuugcacauggguaagncgauccuaagggacgggguaaccccggcagauagcgcacgcgccccgaaagggaaucggguuaagauuucccgagccgggauguggcgguugacggcgacguuaggaaguccggagacgccggcgggggccucgggaagaguuaucuuuucugcuuaacggccugccaacccuggaaacgguucagccggagguaggguccaguggccggaagagcaccggguguccggugcgcccccggcggcccaugaaaauccggaggaccgccguucacgcccggucguacucauaancgnaucangucuncaaggugaacngccucuggccaauggaacaanguaggcaagggaagucggcaaaacggauccguaacuucgggaaaaggauuggcucugaggaccgacucagaacuggnacggacaagnngnauccgacuguuuaauuaaaacaaagcauugcgaugguccucgcggaugcugacgcaaugugauuucugccnagugcucugaaugucaaagugangaaauucaaccaagcncggguaaacggcaagguagcnaanugccucnucaunuaauuagugacgcgcaugaauggauuancgagauucccacugunccugucuacnauccagcgaaaccacagncaagggaacgggcuuggcggaaucancggngaaagaagacccunnugagcuugacncuaguccgacuuugugaauacuuauuccgugggucggaaguuuuggcuccaaggccggccgauccgggcggaagacauugucagguggggaguuuggcugnggcggcacaucuguuaaaagnuaacgcaggnnuccuaagaugagcucaacgagaacagaaaunucguguggaacaaaaggguaaaagcucguuugauncugauuuccagnacgaanacgaaccgugaaagcguggccuaucgauccuuuagcuucggaguuugaagcuanangugucagaaaaguuaccacagngauaacuggcuuguggcagcnaagcgauagcgacguugcuuuuugauccuungaugucggnucunccuaucauugugaagcagaauucaccanguguungaunnuucacccaccanuagggaacgugngnugggnuuagancgucgugagacagguuaguuuuacccuacugaugacagugucgcgauaguaauucaaccuaguacgagaggaaccguugauucacacaauuggucaucgcgcuugguugaaaagccaguggcgcgaagcuaccgugugccggauunugacugaacccucuaagucagaauccaagcuagcaugcgacgccucgacccacguuaggcccaagggcccgugggccgaagugcagcucccuucccgaauccuuuncagacgacnuaagacggggcauuguaaguggcagagugacgauccacugagauccagccccgucgcauucgu ........................<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<.......<.....>......>>>>>..<<<....<......<<<<<<<<<...>>>>>>>>>......>......<<<<<<<<.<<<<<<<<.<<<<<<<.....<<<<......>>>>.((......<<<.....))>>>....>>>>>>>...>>>>>>>>.>>>>>>>>........<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>.................................<<<<<<<<<<<<......<.<<<<<<.<.......<<...<.>...>>........>..>.>>>>>.>.<.<<<<<<......<<....<..<......<..<<..<.......>.>>...>.....>..>....>>........<<.<.<....>.>....<......>......>>..>>>>>>.>....>>>.>>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<...<<<<<<....>>>>>>....>>...<<....>>....<<<<<..<<<<<.>>>>>...>>>>><<<<<<<<.....<....>.....>>.>>>.>>>...>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<.>>>>>>>.....>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<.<<..<<<.<<<<<<<.....<<<....<<<..<.<<..>>.>..>>>..>>.>.....>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.......<..........<<<.<<<<<<...>>>>>>>>>..........))).>....>>>>>>.>>>...>>>>>>><<<<.<<<<.........>>>>.>>>>....>>>>>><.<<<<<<<<<<.......<<<.<<<<....>>>>>>>....>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<<....<<<<<.<<...<<<<<....<<.....>>..>>>>>....((<<<<<<...<<<...<<<....>>>........<<<..>>>..>>>....>>...<<<<<.........>>>>>))<<<<.<<<<<<<<...<<<....>>>...<...<<<<<<...<<<<.<<<<<<<.<<<<<.<<<<...[[..>>>>.><...<<<<<.....<<<<<<....<<<<...>>>>....>>>>>>.....>>>>>....><<<<<.>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>...>..>>>>.>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>.>>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<......>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>>......<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<.<<<...<<<..>>>...<<<<<.....<<<<..............<<<..>>>..>>>>..>>>>>......>>>.>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>>.<<<....>>>.>>))).......<<<<<<<<<<.))))))>>>>>>>>>>..........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<....>>...>>>>>>...>>.>.>.......<<<<<..<<<<<..<<<.<<<<<......>>>>>...>>>.<<<.........>>>.....>>>>>......>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>....<<<<<<<..<<<<...<<<<<.................>>>>>..<<<<<...<<<<....<<<<<<<<<.]]...>>>>..>>>>>...>>>>..>>>>>..<<<...<<<<<..........>>>>>...>>>..>>>>....>>>>>>>.....<<.......<..>....>>.............................<<<<..<.............>.<<<<<<<.<<<....<<<<.<..<<.>>..>>>>>...>>>....>>>>>>>..>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((.......(.]...)......))))...((((.........((((((((((...)))))))))....)........((((((.(..(((((((.(((((((...({((((......)))))[[(...).(((....}]])))....)))))))...)))))))..).))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((.(....).))...........).....................((((((.((.((..(...(....(...........(....(.)....)..............)....).(..(((((......((....(..(......(..((...(.....)..).)..).....)..)....))........((((........).................)))..)))))..)...)))..)).)))))).[((((........))))(((((...(.(.((((.((((((...(....(((........))).....).....(....).....(((((..(((((.)))))...)))))((((((((.....(....).....)).))).)))...)))))).)))).)..((.(...((((((.....((((((((((.((((...(((((((.)))))))...)[)))...(((..((.(........<.))).)))..).))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)(((((.(.((..(((.(((((.(......((.....((..(.((())).)..))...)).......).)))...(((((((((.(......))))))))))....)))))))).))).))..((((....((.....))....))))....(((......)))...(((((((...((([[[...(.((((((.......(..........(((.((((((...)))))))))..........]]].)....))))))))))...)))))))((((.((((.........)))).))))....))))))(.((((((((((.......(((.((((....)))))))....))))))))))..)......)))))((.....((.....((((.(.......).))))((((.....((((..((...((((((...((.....)).))))))....[[(((.((...(((..((((....)))..).....((....))..)))....))...(((((.........)))))]]((((..(((((((..((((....)))...(..<((((((...((((.(((((((((((((.((((...{{..)))).)(...((((((....(((((.....(((.....))).....)))))...).)))))....)(((((.))))))))).).))))))).))))(...)....))))))...)).)))).))).)))).)))..))......(......)..)))).((((.....))))..))))..(((......(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((..)..)))))).))(...).......(((((((((.].(...........)...(((((((....((((....))))......))))))).}.(.(.(((..((((((.(...(......(((......)))......).)))))..)))))......((..........(((((.......)))))..)..)....).)....)).))))))).)..))).)))))))...)))))....)).{...((((.....]}.))))......((((..(((.((......((((.(((((...(((((.(((.(((...(((..)))....((((.....((((..........>...(((())))..))))..)))).......))).)))..)))))..(((......[)).).(((((..........]))))).([((....((((((.(.((((((.......))))))...).((][.[[[))....))))))....(.(..((((....{..))))..).).((......)).))]]].].....((((((((((.]]]]]]))))))))))....)}.....)))..)))))).......(....(.((((.(...((....))...).))))...)....)........((((.((((((..(((.(((((......)))))...))).(((.(.....).))).....)))))..)...))).)......((((((....))).)))...>.))..))).)))).....(((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..)))))..(((...((((............))))...)))..))))....)))))))...(.((.......(())....))).....(.(....)..)............((.(..(..(.......)..).(((((((.(((....((((.(..((.))..)))))...)))....)))))))..).)).. Atomic structure of wheat ribosome reveals unique features of the plant ribosomes; 25S rRNA 8jiv Ab 119 2.84 RF00001 38458197 0003735 0005840 4565 ggaugcgaucauaccagcacuaaggcaucggaucccgucagaacuccgaaguuaagcgugcuugggcgagaguaguacaaggaugggugaccucuugggaaguccucguguugcauucc <<<<<<<<<....<<<<<<<......<<<<<..............>>>..>>.....>>>>>.>><<<<<.<.....<.<<<<.<<....>>>>>>.>....>.>>>>>>>>>>>>>>. (((((((((....(((((((......(.((((...(....)...))))...).....))))).))(((((.......(.(.((.((....)))).).)......)))))))))))))). Atomic structure of wheat ribosome reveals unique features of the plant ribosomes; 5S rRNA 8jiv Ac 152 2.84 RF00002 38458197 0003735 0005840 4565 cgacucucggcaacggauaucucggcucucgcaucgaugaagnacguagcgaaaugcgauaccuggugugaauuncagaauccgugaaccaucgagucuuugaacgcaaguugcgcccgaggggccgagggcacgccugccugggcgucacg .........................................<<<<<<.((.....>>>....<<<<<<......)).............>>>>.>>..>>>....<<.....>><<<<..<<..>>..>>>>.................... .........................................((((((.[[.....))).....((((((.....]]...........).)))).)...)))....((.....))((((..((..))..)))).................... Atomic structure of wheat ribosome reveals unique features of the plant ribosomes; 5.8S rRNA 8k0p A 542 2.99 RF00029 38301022 0000373 150248 gugcgcucggcaugggugcaaucucuagggugaaagucccgaacugcgaaggcagaaguagcaguuagcuuaacgcaaggguguccguggugacgcggaaucugaaggaagcgggcggcaaacuuccggucugaggaacacgaacuucauauaaggcuagguaucauuggaugaguuugcaagacaaaacaaaguccuuucugccgaaggugauacagaguaaaugaagcagauagauggaaggaaagauuguacucuuacccgaggaggucugauggauacgugaagugcgcuucauaaccuacuuagugauaaguaacugaaccaucagaagucagcagaggucauaguacgaaucggucuagaacgauucggaaggacugaacaaucaagagaaaauagcgaaaggaaacggugaaucccgugggaaucgcuauuuacggaaggaagcuugcgucauuaucuugauugaaccgccguauacggaaccguacguacgguggugugagaggacggagguuaaucaccuccuccuacucgau .....<<<<<...<<<<<<<<<<<...<<<.......>>>..(((((...<<<<<<<...)))))..<<<...<<<..<<<<..<<<<<....>>>>>.>>>>.......>>>...>>>...[[[[[[[[[[[...........[[[[[......[[[..(((((((.<<<<..<<<<........>>>>...>>>>.>>>>>>>....)))))))..]]]...]]]]]]]]]]...]]]]]]...>>>>>>>>>>>....>>>>>...<<<<<<<<<.....<<<<<<..>>>>>>.....<<<<<<....>>>>>>......>>>>>>>>..>.......<<<<......<<<<<<<........>>>>>>>....>>>>...<<<<<<<<<..<<<<<<..<......<<<<......>>>>.....>..>>>>>><<<.<<<....>>>.>>>.....>>>>>>>>>.<<<<<<<<<<<<<....>>>..>>>>>>>>>>..<<<<<<<.<<<<<<.....>>>>>>>>>>.>>>... ..[<.((((({..(((((((((((...(((.......)))..(((((...[[[[[[[...)))))..(((...(((..((((..(((((....))))).))))...>}..)))...)))...(((((((((((.(.....)...(((((.....[(((..((((((((((((..((((.]......))))...)))).]]]]]]].{.))))))))..)))...))))))))))...))))))...)))))))))))...])))))(...((((((((.......(((....))).......((((.(....).))))......))))))))...)(.....((((.(....(((((((........)))))))...)))))...(((((((((..(((((((((......((((....}.)))).....)))))))))(((.(((....))).))).....))))))))).(((((((((((((....)))..))))))))))..(((((((.((((((.....)))))))))).)))..) The Anoxybacillus pushchinoensis ORF-less Group IIC Intron HYER1 at symmetric apo state; RNA (542-MER) 8k0p C 542 2.99 RF00029 38301022 0000373 150248 gugcgcucggcaugggugcaaucucuagggugaaagucccgaacugcgaaggcagaaguagcaguuagcuuaacgcaaggguguccguggugacgcggaaucugaaggaagcgggcggcaaacuuccggucugaggaacacgaacuucauauaaggcuagguaucauuggaugaguuugcaagacaaaacaaaguccuuucugccgaaggugauacagaguaaaugaagcagauagauggaaggaaagauuguacucuuacccgaggaggucugauggauacgugaagugcgcuucauaaccuacuuagugauaaguaacugaaccaucagaagucagcagaggucauaguacgaaucggucuagaacgauucggaaggacugaacaaucaagagaaaauagcgaaaggaaacggugaaucccgugggaaucgcuauuuacggaaggaagcuugcgucauuaucuugauugaaccgccguauacggaaccguacguacgguggugugagaggacggagguuaaucaccuccuccuacucgau .....<<<<<...<<<<<<<<<<<...<<<.......>>>..(((((...<<<<<<<...)))))..<<<...<<<..<<<<..<<<<<....>>>>>.>>>>.......>>>...>>>...[[[[[[[[[[[...........[[[[[......[[[..(((((((.<<<<..<<<<........>>>>...>>>>.>>>>>>>....)))))))..]]]...]]]]]]]]]]...]]]]]]...>>>>>>>>>>>....>>>>>...<<<<<<<<<.....<<<<<<..>>>>>>.....<<<<<<....>>>>>>......>>>>>>>>..>.......<<<<......<<<<<<<........>>>>>>>....>>>>...<<<<<<<<<..<<<<<<..<......<<<<......>>>>.....>..>>>>>><<<.<<<....>>>.>>>.....>>>>>>>>>.<<<<<<<<<<<<<....>>>..>>>>>>>>>>..<<<<<<<.<<<<<<.....>>>>>>>>>>.>>>... ..[<.((((({..(((((((((((...(((.......)))..(((((...[[[[[[[...)))))..(((...(((..((((..(((((....))))).))))...>}..)))...)))...(((((((((((.(.....)...(((((.....[(((..((((((((((((..((((.]......))))...)))).]]]]]]].{.))))))))..)))...))))))))))...))))))...)))))))))))...])))))(...((((((((.......(((....))).......((((.(....).))))......))))))))...)(.....((((.(....(((((((........)))))))...)))))...(((((((((..(((((((((......((((....}.)))).....)))))))))(((.(((....))).))).....))))))))).(((((((((((((....)))..))))))))))..(((((((.((((((.....)))))))))).)))..) The Anoxybacillus pushchinoensis ORF-less Group IIC Intron HYER1 at symmetric apo state; RNA (542-MER) 8k0q A 542 3.14 RF00029 38301022 0000373 150248 gugcgcucggcaugggugcaaucucuagggugaaagucccgaacugcgaaggcagaaguagcaguuagcuuaacgcaaggguguccguggugacgcggaaucugaaggaagcgggcggcaaacuuccggucugaggaacacgaacuucauauaaggcuagguaucauuggaugaguuugcaagacaaaacaaaguccuuucugccgaaggugauacagaguaaaugaagcagauagauggaaggaaagauuguacucuuacccgaggaggucugauggauacgugaagugcgcuucauaaccuacuuagugauaaguaacugaaccaucagaagucagcagaggucauaguacgaaucggucuagaacgauucggaaggacugaacaaucaagagaaaauagcgaaaggaaacggugaaucccgugggaaucgcuauuuacggaaggaagcuugcgucauuaucuugauugaaccgccguauacggaaccguacguacgguggugugagaggacggagguuaaucaccuccuccuacucgau .....<<<<<...<<<<<<<<<<<...<<<.......>>>..(((((...<<<<<<<...)))))..<<<...<<<..<<<<..<<<<<....>>>>>.>>>>.......>>>...>>>...[[[[[[[[[[[...........[[[[[......[[[..(((((((.<<<<..<<<<........>>>>...>>>>.>>>>>>>....)))))))..]]]...]]]]]]]]]]...]]]]]]...>>>>>>>>>>>....>>>>>...<<<<<<<<<.....<<<<<<..>>>>>>.....<<<<<<....>>>>>>......>>>>>>>>..>.......<<<<......<<<<<<<........>>>>>>>....>>>>...<<<<<<<<<..<<<<<<..<......<<<<......>>>>.....>..>>>>>><<<.<<<....>>>.>>>.....>>>>>>>>>.<<<<<<<<<<<<<....>>>..>>>>>>>>>>..<<<<<<<.<<<<<<.....>>>>>>>>>>.>>>... ..[<.((((({..(((((((((((...(((.......)))..(((((...[[[[[[[...)))))..(((...(((..((((..(((((....))))).))))...>}..)))...)))...(((((((((((.(.....)...(((((.....[(((..((((((((((((..((((.]......))))...)))).]]]]]]].{.))))))))..)))...))))))))))...))))))...)))))))))))...])))))(...((((((((.......(((....))).......((((.(....).))))......))))))))...)(.....((((.(....(((((((........)))))))...)))))...(((((((((..(((((((((......((((....}.)))).....)))))))))(((.(((....))).))).....))))))))).(((((((((((((....)))..))))))))))..(((((((.((((((.....)))))))))).)))..) The Anoxybacillus pushchinoensis ORF-less Group IIC Intron HYER1 at symmetric pre-cleavage state; RNA (542-MER) 8k0q C 542 3.14 RF00029 38301022 0000373 150248 gugcgcucggcaugggugcaaucucuagggugaaagucccgaacugcgaaggcagaaguagcaguuagcuuaacgcaaggguguccguggugacgcggaaucugaaggaagcgggcggcaaacuuccggucugaggaacacgaacuucauauaaggcuagguaucauuggaugaguuugcaagacaaaacaaaguccuuucugccgaaggugauacagaguaaaugaagcagauagauggaaggaaagauuguacucuuacccgaggaggucugauggauacgugaagugcgcuucauaaccuacuuagugauaaguaacugaaccaucagaagucagcagaggucauaguacgaaucggucuagaacgauucggaaggacugaacaaucaagagaaaauagcgaaaggaaacggugaaucccgugggaaucgcuauuuacggaaggaagcuugcgucauuaucuugauugaaccgccguauacggaaccguacguacgguggugugagaggacggagguuaaucaccuccuccuacucgau .....<<<<<...<<<<<<<<<<<...<<<.......>>>..(((((...<<<<<<<...)))))..<<<...<<<..<<<<..<<<<<....>>>>>.>>>>.......>>>...>>>...[[[[[[[[[[[...........[[[[[......[[[..(((((((.<<<<..<<<<........>>>>...>>>>.>>>>>>>....)))))))..]]]...]]]]]]]]]]...]]]]]]...>>>>>>>>>>>....>>>>>...<<<<<<<<<.....<<<<<<..>>>>>>.....<<<<<<....>>>>>>......>>>>>>>>..>.......<<<<......<<<<<<<........>>>>>>>....>>>>...<<<<<<<<<..<<<<<<..<......<<<<......>>>>.....>..>>>>>><<<.<<<....>>>.>>>.....>>>>>>>>>.<<<<<<<<<<<<<....>>>..>>>>>>>>>>..<<<<<<<.<<<<<<.....>>>>>>>>>>.>>>... ..[<.((((({..(((((((((((...(((.......)))..(((((...[[[[[[[...)))))..(((...(((..((((..(((((....))))).))))...>}..)))...)))...(((((((((((.(.....)...(((((.....[(((..((((((((((((..((((.]......))))...)))).]]]]]]].{.))))))))..)))...))))))))))...))))))...)))))))))))...])))))(...((((((((.......(((....))).......((((.(....).))))......))))))))...)(.....((((.(....(((((((........)))))))...)))))...(((((((((..(((((((((......((((....}.)))).....)))))))))(((.(((....))).))).....))))))))).(((((((((((((....)))..))))))))))..(((((((.((((((.....)))))))))).)))..) The Anoxybacillus pushchinoensis ORF-less Group IIC Intron HYER1 at symmetric pre-cleavage state; RNA (542-MER) 8k0r A 542 2.65 RF00029 38301022 0000373 150248 gugcgcucggcaugggugcaaucucuagggugaaagucccgaacugcgaaggcagaaguagcaguuagcuuaacgcaaggguguccguggugacgcggaaucugaaggaagcgggcggcaaacuuccggucugaggaacacgaacuucauauaaggcuagguaucauuggaugaguuugcaagacaaaacaaaguccuuucugccgaaggugauacagaguaaaugaagcagauagauggaaggaaagauuguacucuuacccgaggaggucugauggauacgugaagugcgcuucauaaccuacuuagugauaaguaacugaaccaucagaagucagcagaggucauaguacgaaucggucuagaacgauucggaaggacugaacaaucaagagaaaauagcgaaaggaaacggugaaucccgugggaaucgcuauuuacggaaggaagcuugcgucauuaucuugauugaaccgccguauacggaaccguacguacgguggugugagaggacggagguuaaucaccuccuccuacucgau .....<<<<<...<<<<<<<<<<<...<<<.......>>>..(((((...<<<<<<<...)))))..<<<...<<<..<<<<..<<<<<....>>>>>.>>>>.......>>>...>>>...[[[[[[[[[[[...........[[[[[......[[[..(((((((.<<<<..<<<<........>>>>...>>>>.>>>>>>>....)))))))..]]]...]]]]]]]]]]...]]]]]]...>>>>>>>>>>>....>>>>>...<<<<<<<<<......<<<<....>>>>......<<<<<<....>>>>>>......>>>>>>>>..>.......<<<<......<<<<<<<........>>>>>>>....>>>>...<<<<<<<<<..<<<<<<..<......<<<<......>>>>.....>..>>>>>><<<.<<<....>>>.>>>.....>>>>>>>>>.<<<<<<<<<<<<<....>>>..>>>>>>>>>>..<<<<<<<.<<<<<<.....>>>>>>>>>>.>>>... ..[<.((((({..(((((((((((...(((.......)))..(((((...[[[[[[[...)))))..(((...(((...(((..(((((....))))).)))....>}..)))...)))...(((((((((((.(.....)...(((((.....[(((..((((((((((((..((((.]......))))...)))).]]]]]]].{.))))))))..)))...))))))))))...))))))...)))))))))))...])))))(...((((((((......((((....))))......((((.(....).))))......))))))))...)(.....((((.(....(((((((........)))))))...)))))...(((((((((..(((((((((......((((....}.)))).....)))))))))(((.(((....))).))).....))))))))).(((((((((((((....)))..))))))))))..(((((((.((((((.....)))))))))).)))..) The Anoxybacillus pushchinoensis ORF-less Group IIC Intron HYER1 at symmetric post cleavge state; RNA (542-MER) 8k0r C 542 2.65 RF00029 38301022 0000373 150248 gugcgcucggcaugggugcaaucucuagggugaaagucccgaacugcgaaggcagaaguagcaguuagcuuaacgcaaggguguccguggugacgcggaaucugaaggaagcgggcggcaaacuuccggucugaggaacacgaacuucauauaaggcuagguaucauuggaugaguuugcaagacaaaacaaaguccuuucugccgaaggugauacagaguaaaugaagcagauagauggaaggaaagauuguacucuuacccgaggaggucugauggauacgugaagugcgcuucauaaccuacuuagugauaaguaacugaaccaucagaagucagcagaggucauaguacgaaucggucuagaacgauucggaaggacugaacaaucaagagaaaauagcgaaaggaaacggugaaucccgugggaaucgcuauuuacggaaggaagcuugcgucauuaucuugauugaaccgccguauacggaaccguacguacgguggugugagaggacggagguuaaucaccuccuccuacucgau .....<<<<<...<<<<<<<<<<<...<<<.......>>>..(((((...<<<<<<<...)))))..<<<...<<<..<<<<..<<<<<....>>>>>.>>>>.......>>>...>>>...[[[[[[[[[[[...........[[[[[......[[[..(((((((.<<<<..<<<<........>>>>...>>>>.>>>>>>>....)))))))..]]]...]]]]]]]]]]...]]]]]]...>>>>>>>>>>>....>>>>>...<<<<<<<<<......<<<<....>>>>......<<<<<<....>>>>>>......>>>>>>>>..>.......<<<<......<<<<<<<........>>>>>>>....>>>>...<<<<<<<<<..<<<<<<..<......<<<<......>>>>.....>..>>>>>><<<.<<<....>>>.>>>.....>>>>>>>>>.<<<<<<<<<<<<<....>>>..>>>>>>>>>>..<<<<<<<.<<<<<<.....>>>>>>>>>>.>>>... ..[<.((((({..(((((((((((...(((.......)))..(((((...[[[[[[[...)))))..(((...(((...(((..(((((....))))).)))....>}..)))...)))...(((((((((((.(.....)...(((((.....[(((..((((((((((((..((((.]......))))...)))).]]]]]]].{.))))))))..)))...))))))))))...))))))...)))))))))))...])))))(...((((((((......((((....))))......((((.(....).))))......))))))))...)(.....((((.(....(((((((........)))))))...)))))...(((((((((..(((((((((......((((....}.)))).....)))))))))(((.(((....))).))).....))))))))).(((((((((((((....)))..))))))))))..(((((((.((((((.....)))))))))).)))..) The Anoxybacillus pushchinoensis ORF-less Group IIC Intron HYER1 at symmetric post cleavge state; RNA (542-MER) 8k0s A 543 3.41 RF00029 38301022 0000373 150248 gugcgcucggcaugggugcaaucucuagggugaaagucccgaacugcgaaggcagaaguagcaguuagcuuaacgcaaggguguccguggugacgcggaaucugaaggaagcgggcggcaaacuuccggucugaggaacacgaacuucauauaaggcuagguaucauuggaugaguuugcuaagacaaaacaaaguccuuucugccgaaggugauacagaguaaaugaagcagauagauggaaggaaagauuguacucuuacccgaggaggucugauggauacgugaagugcgcuucauaaccuacuuagugauaaguaacugaaccaucagaagucagcagaggucauaguacgaaucggucuagaacgauucggaaggacugaacaaucaagagaaaauagcgaaaggaaacggugaaucccgugggaaucgcuauuuacggaaggaagcuugcgucauuaucuugauugaaccgccguauacggaaccguacguacgguggugugagaggacggagguuaaucaccuccuccuacucgau .....<<<<<...<<<<<<<<<<<...<<<.......>>>..(((((...<<<<<<<...)))))..<<<...<<<..<<<<..<<<<<....>>>>>.>>>>.......>>>...>>>...[[[[[[[[[[[...........[[[[[......[[[..(((((((.<<<<..<<<<.........>>>>...>>>>.>>>>>>>....)))))))..]]]...]]]]]]]]]]...]]]]]]...>>>>>>>>>>>....>>>>>...<<<<<<<<<.....<<<<<<..>>>>>>.....<<<<<<....>>>>>>......>>>>>>>>..>.......<<<<......<<<<<<<........>>>>>>>....>>>>...<<<<<<<<<..<<<<<<..<......<<<<......>>>>.....>..>>>>>><<<.<<<....>>>.>>>.....>>>>>>>>>.<<<<<<<<<<<<<....>>>..>>>>>>>>>>..<<<<<<<.<<<<<<.....>>>>>>>>>>.>>>... ..[<.((((({..(((((((((((...(((.......)))..(((((...[[[[[[[...)))))..(((...(((..((((..(((((....))))).))))...>}..)))...)))...(((((((((((.(.....)...(((((......(((..((((((((((((..((((.........))))...)))).]]]]]]].{.))))))))..)))...))))))))))...))))))...)))))))))))...])))))(...((((((((.......(((....))).......((((.(....).))))......))))))))...)(.....((((.(....(((((((........)))))))...)))))...(((((((((..(((((((((......((((....}.)))).....)))))))))(((.(((....))).))).....))))))))).(((((((((((((....)))..))))))))))..(((((((.((((((.....)))))))))).)))..) The Anoxybacillus pushchinoensis ORF-less Group IIC Intron HYER1 with 10-nt TRS at symmetric apo state; RNA (543-MER) 8k0s C 543 3.41 RF00029 38301022 0000373 150248 gugcgcucggcaugggugcaaucucuagggugaaagucccgaacugcgaaggcagaaguagcaguuagcuuaacgcaaggguguccguggugacgcggaaucugaaggaagcgggcggcaaacuuccggucugaggaacacgaacuucauauaaggcuagguaucauuggaugaguuugcuaagacaaaacaaaguccuuucugccgaaggugauacagaguaaaugaagcagauagauggaaggaaagauuguacucuuacccgaggaggucugauggauacgugaagugcgcuucauaaccuacuuagugauaaguaacugaaccaucagaagucagcagaggucauaguacgaaucggucuagaacgauucggaaggacugaacaaucaagagaaaauagcgaaaggaaacggugaaucccgugggaaucgcuauuuacggaaggaagcuugcgucauuaucuugauugaaccgccguauacggaaccguacguacgguggugugagaggacggagguuaaucaccuccuccuacucgau .....<<<<<...<<<<<<<<<<<...<<<.......>>>..(((((...<<<<<<<...)))))..<<<...<<<..<<<<..<<<<<....>>>>>.>>>>.......>>>...>>>...[[[[[[[[[[[...........[[[[[......[[[..(((((((.<<<<..<<<<.........>>>>...>>>>.>>>>>>>....)))))))..]]]...]]]]]]]]]]...]]]]]]...>>>>>>>>>>>....>>>>>...<<<<<<<<<.....<<<<<<..>>>>>>.....<<<<<<....>>>>>>......>>>>>>>>..>.......<<<<......<<<<<<<........>>>>>>>....>>>>...<<<<<<<<<..<<<<<<..<......<<<<......>>>>.....>..>>>>>><<<.<<<....>>>.>>>.....>>>>>>>>>.<<<<<<<<<<<<<....>>>..>>>>>>>>>>..<<<<<<<.<<<<<<.....>>>>>>>>>>.>>>... ..[<.((((({..(((((((((((...(((.......)))..(((((...[[[[[[[...)))))..(((...(((..((((..(((((....))))).))))...>}..)))...)))...(((((((((((.(.....)...(((((......(((..((((((((((((..((((.........))))...)))).]]]]]]].{.))))))))..)))...))))))))))...))))))...)))))))))))...])))))(...((((((((.......(((....))).......((((.(....).))))......))))))))...)(.....((((.(....(((((((........)))))))...)))))...(((((((((..(((((((((......((((....}.)))).....)))))))))(((.(((....))).))).....))))))))).(((((((((((((....)))..))))))))))..(((((((.((((((.....)))))))))).)))..) The Anoxybacillus pushchinoensis ORF-less Group IIC Intron HYER1 with 10-nt TRS at symmetric apo state; RNA (543-MER) 8k0y A 50 2.28 RF01684 8090 gacgccggugguggcacuccugaggacgggguucaauucccugcgguguc <<<<<<.<<<....>>><<<<.>>>><<<<<.......>>>>>.>>>>>> ((((((((((...[)))((((.))))(((((..]....)))))))))))) Crystal structure of a medaka mascRNA U23G; RNA (56-MER) 8k0y B 50 2.28 RF01684 8090 gacgccgguggggcacuccuggaggacgggguucaauucccugcgguguc <<<<<<.<<<...>>><<<<..>>>><<<<<.......>>>>>.>>>>>> ((((((((((..[)))((((..))))(((((..]....)))))))))))) Crystal structure of a medaka mascRNA U23G; RNA (56-MER) 8k1e B 54 2.23 RF01684 9606 ggcgcugguggggcacguccagcgcugggccgggguucgaguccccgcaguguu <<<<<<.<<<...>>><<<<<<..>>>>>><<<<<.......>>>>>.>>>>>> (.((((((((..[)))((((((()))))))(((((..]....)))))))))).) Crystal structure of a human menRNA; RNA (58-MER) 8k2a L1 1500 2.9 RF02541 38942792 0003735 0005840 9606 gcuaaaccuagccccaaacccacuccaccuuacuaccagacaaccuuagccaaaccauuuacccaaauaaaguauaggcgauagaaauugacuggcgcaauagauauaguaccgcaagggaaagaugaaaaauuauaaccaagcauaauauagcaaggacuaaccccuauaccuucugcauaaugaauuaacuagaaauaacuuugcaaggagagccaaagcuaagacccccgaaaccagacgagcuaccuaagaacagcuaaaagagcacacccgucuauguagcaaaauagugggaagauuuauagguagaggcgacaaaccuaccgagccuggugauagcugguuguccaagauagaaucuuaguucaacuuuaaauuugcccacagaaccaaauccccuuguaaauuuaacuguuaguccaaagaggaacagcucuuuggacacuaggaaaaaaccuuguagagagaguaaaaaauuuaacacccauaguaggccuaaaagcagccaccaauuaagaaagcguucaagcucaacacccacuaccuaaaaaaucccaaacauauaacugaacuccucacacccaauuggaccaaucuaucacccuauagaagaacuaauguuaguauaaguaacaugaaaacauucuccuccgcauaagccugcgucagaucacacugacaauuaacagcccaauaucuacaaucaaccaacaagucauuauuacccucacugucaacccaacacaggcaugcucauaaggaaagguuaaaaaaaguaaaaggaacucggcaaaucuuaccccgccuguuuaccaaaaacaucaccucuagcaucaccaguauuagaggcaccgccugcccagugacacauguuuaacggccgcgguacccuaaccgugcaaagguagcauaaucacuuguuccuuaaauagggaccuguaugaauggcuccacgaggguucagcugucucuuacuuuuaaccagugaaauugaccugcccgugaagaggcgggcauaacacagcaagacgagaagacccuauggagcuuuaauuuauuaaugcaaacaguaaccugcauuaaaaauuucgguuggggcgaccucggagcagaacccaaccuccgagcaguacaugcuaagacuucaccagucaaagcgaaccucaauugauccaauaacuugaccaacggaacaaguuacccuagggauaacagcgcaauccuauucuagaguccauaucaacaauaggguuuacgaccucgauguuggaucaggacaucccgauggugcagccgcuauuaaagguucguuuguucaacgauuaaaguccuacgugaucugaguucagaccggaguaauccaggucgguuucuaucuacuuuaaauuccucccuguacgaaaggacaagagaaauaaggccuacuucacaaagcgccuucccccguaaaugauaucaucucaacuuagauacccacacccacccaagaacaggguu <<<.......<<<<.....................................<......>...............<<.....>>..........>>.>>.............<<....>>......................>>>...........<<<.......>>>...<.<........>.>.<<<<<<.........<<<.<<..<<....>>...>>.>>>...<<.<...<<<<.<.....<<<<<.<<<..<<<.....>>>...<<<..<<<<........>>>>.>>>....>>>.>>>>>...<<.......>>......>.>>>>......>.>>..<<<<<<....<<<<....>>>><<<.<<<<<<<<<<.....<<......>>.....>>>>>>>>>>..>>>.<<<<<<<<<<......>>>>>>>>>>...<<<......>>>....<<<.<<<...<..............<....<<<.........>>>....>.......<<<......>>>....................................>...>>>>>>........>>>>>>...<<<<<......>>>>>.........>>>>>><......<<..<<<....>>><<<<..<<<<........<<<<<......>>>>>......<<<...<<<<.......................>>>>.......>>>.....<<......>>.>>>>.....>>>>..<<<<...<<<<<<<<.<<.........<......<<<<<<..<<<.........>>>...<<<<<<.............>>>>>>....<<<.<<<..<<<<<....>>>..>>>>><<<<<<......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>....>>.>>>>.....>..>>.>>>>>>>>>>>>.>>.....>.....<<<<<........>>>>>.......<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<..........>>>>>>>>>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<.....<<<..<<<<.....>>>>..>>>....>>.........<<<....>>>............>>>>..>>>>>>.......<<<..<.<<<<<<...<<.......>>...>>>>>>...>.>>.>.......<<<<<.<<<<<<..<<.<<<<<<......>>>>>>...>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>....<<<.<<<.................>>>.>>><<<<<...<<<....>>>.>>>>>......<<<................>>>.............<<<<.......>>>>. ((.....(..((((.....................................(...[..).........(.....((.]...))....).....)).)).............((....))....).....(...)........)).........(.(((.......))).[.(.(........).).((((((.........(((.((..((....))...)).)))...((.(...((((.(.....(((((.((((.(((....[)))...(((..((((.......{)))).)))..).))).))))).(.((.......))...)..).))))......).))..((((((....((((....)))).((.((((((((((.....((......)).....))))))))))..))..((((((((((......))))))))))...(((......)))....(((.(((...(..............(.(..(((.........)))..).)....(..(((......))))...................................)...))))))........))))))...(((((......))))).........))))))(......((..(((....)))(((...((((......(.(((((......)))))......(((...((((...............(..)....)))).......))).)...((......)).))))......)))..((((....(((((((.((..(....(........((((((.].((.........))....((((((.............))))))....(((.(((..(((((....)))..)))))(((((........)))))........((..........(((((.......)))))..)..)....)))....)).))))....)..))).))))))).)))).)).....)).{..(((((.....]}.))))).......((..(((.((......((((.((((((..(((((.((((((((..........)))))))))))))..(((......[)))((((((..........]))))))(.((.....((...(((....[..)))...))....)).........(((....))).....)].....))))..))))))......((((..(.((((((.(.((.......)))..))))))...).)).).)......((((.((((((..((.((((((......))))))...)).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..}.))..))).))..(.(((.(((......(....).....))).)))(((((...(((....))).)))))......(((................)))..)..........((((.......)))). Cryo-EM structure of the human 55S mitoribosome with Tigecycline; 16S rRNA 8k2a S1 928 2.9 RF00177 URS00021ED90F_9606 38942792 0003735 0005840 9606 auagguuugguccuagccuuucuauuagcucuuaguaagauuacacaugcaagcauccccguuccagugaguucacccucuaaaucgaucaaaaggaacaagcaucaagcacgcagcaaugcagcucaaaacgcuuagccuagccacacccccacgggaaacagcagugauuaaccuuuagcaauaaacgaaaguuuaacuaagcuauacuaaccccaggguuggucaauuucgugccagccaccgcggucacacgauuaacccaagucaauagaaccggcguaaagaguguuuuagaucacaauaaagcuaaaacucaccugaguuguaaaaaacuccaguugacacaaaauagacuacgaaaguggcuuuaacauaucugaacacacaauagcuaagacccaaacugggauuagauaccccacuaugcuuagcccuaaaccucaacaguucaacaaaacugcucgccagaacacuacgagccacagcuuaaaacucaaaggaccuggcggugcuucauaucccucuagaggagccuguucuguaaucgauaaaccccgaucaaccucaccaccucuugcucagccuauauaccgccaucuucagcaaacccugaugaaggcuacaaaguaagcgcaaguacccacguaaagacguuaggucaagguguagcccaugagguggcaagaaaugggcuacauuuucuaccccagaaacgauagcccuuaugaaauaagggucgaagguggauuuagcaguaaacuaagaguagagugcuuaguugaacagggcccugaagcgcguacacaccgcccgucacccuccucaaguauacuucaaaggacaauuaacuaaaaccccuacgcauuuauauagaggagacaagucguaacaugguaaguguacuggaaagugcacuuggacgaac ..((((..<<<<<<.)))).<<<<<<.<<..<<<<<<<<....<<<.<<<..<......>......<<........<<<.<..<<..>>.>..>>>...<<<<....<<...<<<....>>>..>>......>>>>.<<...>>.>>.<<<....>>>.....>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>.....<<<<<<<<.....(((.....((.>>>)).......)))..>>>>>..>>.>>>>>>...<<<((.....<<<<..<<<<......<<<<<<......<<<.<<<.<<<......>>>..>>>.>>>.............<<....>>.>>>>>>.....>>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<.<<<<<..))..>>>>>.>.>>>.<<.......<<<<....>>>>.....>>..>>>>>><<<<<.<<<<<<<...<<<.<<<<<..<<<<<<<<<<.....<<........>>..........<<<<<<<.......<<.<<<..<<<<<<.......<<..<<<<<.....>>>.......>>..>>.....<<<....>>>.........>>>...>>>>>>>>....>>>>>>>..>>.>>>>>>>>.....<<<<.....>>>>.<....<<<<<<<.....>>>>>>>....>.....>>>>>.....<<<<<<<.........>>>>>>>.....>>>...>>>>>>>>>>.>>....<..<<.<...<<<<<<..<<<<<......<<<....<<.....>>...>>>.......>>>>>.>>>>>>....>.>>...>.....<<<<<<<<<....>>>>>>>>>........ [.[[[[..(((((..]]]]]((((((.((..((((((((..(.(((.(((..(......)......(((.......(((.(..((())).)..)))...((((....((..((((....))).)))......)))).((...))))).(((....))).....)))))))......(.(((...(((((....)))).))))).)).)))))).....((((([[[.....(((.....((.]]])).......)))..)))))..)).))))))...((([[...(.((((...(((......(((((((.....(((.(((.((........))..))).))).....).....(.((....))))))))).....)))....))))....((((((...((...((((.........))))...))))))))......{...(.(((((..]]..))))).))))).((.......((((....)))).....))...)))))(((((.(((((((...(((.(((((..((((((((((.....((........))..........(((((((.......((.(((...((((((.(....((..(((((.....))).......))..)).....(((....))).....).).)))...)).)))))....)))))))..)).)))))))).(...((((.....))))......(((((((.....))))))).......)..))))).....(((((((.........))))))).....)))...)))))))))).))..(.(..((.(...((((((...((((..((..(((....((.....))...)))..).)..))))..))))))....).))...)..)..(((((((((....)))))))))}....... Cryo-EM structure of the human 55S mitoribosome with Tigecycline; 12S rRNA 8k2c L5 3771 2.4 RF02543 38942792 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcggcccggcggaucuuucccgcgcgggggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucgggggcccccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcgcucuccccccucccggcgcgccggggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccgggggaggccacgcgcgcgucccccgaagagggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcagacccgacgcgccacgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagcggcggcccggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcugggucggucgcggccggcgccuagcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacaugagagguguagaauaagugggaggcccccggcgcccccccgguguccccgcgaggggcccggggcgggguccgccggcccugcgggccgccggugaaauaccacuacucugaucguuuuuucacugacccggugaggcgggggggcgagccccgaggggcucucgcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccggucccccgccgggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..[[[..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>>..<<<<<<<<<<...<<<<<<<<.<<<....<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>>>>>>>>>>>>..>>>>>>>>>>.......<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<<<..<<<<<<<...<<..<.....<<<<.<<<..<<<<..>>>>>>>>>>>.>..>>..>>>>...>>>>>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<<<<<<<<<<<<<<<<<...<<..<<<.<..<<<<......<<<<<<<<..>>>>>>>>.......>>>>..>>>>........>>>>>>..>>>>>>>>>>>....................<<<<<<.<<<<<<<............>>>>>>>.<<<<<<.<<<<.<<<<<<<<<<<.<<<<<.<<<<<<<...........>.>>>>>>.>>>>>.>.>>>>>>>.>>>...>>>>..>>>>.>>..<<<<<<<<<<.....>>>>>>>>.>>....>>>>>>.....>>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<<<<...<<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<......>>>>>>>..<<<<<...<<<..<<<..((((.((((>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>>.<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<....................<<<.<<<<<<<<<...<<<....<<<..<.<<<....<<.............>>..>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.........>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<......<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>....>>>>>..>>>...>>>>>>><<<<<<.<<<..........)))).))))...<.....>..................>>>>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<...<....>..>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<..<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..{{{..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<.<<<<<<<<<<<..<<..........>>.......>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.....<<.....<<<<....>>>>.....>>..>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<<.<<<<<<<<<<<<..<.................................<........................>.............................................>...>>.>>>>>>>>>>...<<<<<.....<<<<.....<..............>................<<<<<<<<<<.......>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>><<<<....>>>>>>)))]......((((((..(((..>>>>>>.)))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]].....<<<<<<.<..<<<....<<<<<.................>>>>>..<<<<....<<<<....<<.<<<<<<<}}}.>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.....<<<<<<<.<<..<<<<....<<<........<<<<<.<<<<....>>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>..............>>>>..>>>>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<.<..<<<<<......>>>>>..>>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((...((((((((((.....)))))).)))).....)))....((((((((((...((((((((..(.....((((((((..({((((......)))))....[[(...).(((....}]])))...).))))))).).))))))))..))))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....(((((((((((..(((((((...((..((....((((.((...((.(..).)).))))))))..))..))))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((.(..((((......((((((((())))))))).......))))..))))........))))))..)))))))))))....................((((((.((((((.....(.....)..)))))).((((((.((((.(((((((((((.(((((.((((.(..............).))))).)))).).))))))).)))...))))..)))).))..((((((((((.....)))))))).))..[.)))))).....))).)))))...)))))...)))))))).<((((........))))((((((..(.(((((((((((((..(((..(((((........))))..)..)))...((....))...(((((((......)))))))..(((((...(((..(((..[[[[.[[[[)))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))..).))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((.(((((((....................(((.((((((((....(((....(((..(.(((..(..................).))).)..)))..)).)....))))))...(((((((((.(......))))))))))....))))))))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.....{.(((((.(((...((...([...)))...))).....(...((.]....)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((..........]]]].]]]]]..(......)....(...)........)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((..(((((((...((.....)).))))))....[[(((.((...((....(((....)))..........((.((((....(....)...))))))......))....))...(((((........)))))]]((((....(((((...(((((((....)))))))..((((....)))...(...((((((...(((((((((((((((((((((((..{{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).))).))).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((...(([...)...])........)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(..........((((....))))........)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.(.......((((.((((((..(((((.(((((((((.((((((((((((...............................................................................................................)).))))))))))...(((((.....((((.....((............))................((((((((((.......))))))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a..)..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}}.)))))..)).))...))))...)))).((((...((((.....}.......))))...))))..)))...).)))))).....(((((((.((..((((.(..(((........(((((.((((.(.))))).))))).......)))...(((..(((......(((.(((((((......)))))))))).....)))..)))...........)..))))..)))))))))(((((.(..(.......)..)....((.(((((((.((.....((((.(..(((((......)))))..)))))....))....)))).))).))..))))).. Cryo-EM structure of the human 80S ribosome with Tigecycline; 28S rRNA 8k2c L7 120 2.4 RF00001 38942792 0003735 0005840 9606 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. Cryo-EM structure of the human 80S ribosome with Tigecycline; 5S rRNA 8k2c L8 156 2.4 RF00002,RF02540 38942792 0003735 0005840 9606 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<<<<....>>>>.....<.<<<......>>.............>>>..>...>>>....<<....>><<<<<<<<<.....>>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))(((((((((.....))))))))).................... Cryo-EM structure of the human 80S ribosome with Tigecycline; 5.8S rRNA 8k2c S2 1740 2.4 RF01960,RF02542,RF01959,RF00177 URS00021ED8E3_9606 38942792 0003735 0005840 9606 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucgcuccucucccacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgccccccguggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuccgcgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcgggcguccccgcccucucggccggggcccgaagcauuuacuuugaaaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggucggcccacggcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<....<<....<<<<<..................<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<<.....>.>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<<......>>>>>>>>.>>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....<<<<<<<<<.<<<....>>>..>>>>>.>>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<.......................<<.<.............>>>...<<<<<<.<.......<<...<.......>.<<<<.......>>>>...>>......>.>>>..>>>........<.<<.<<<<<<<...............>>>>>>>.>>.>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<.......>>>>.>>>>.....>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<...<<<...................>>>.....>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..((....(((((...((.............((.....((.(((.....))).))......))......)).((((...((((........))))...))))((..(((((...(......)..)))))......)).(.((((.((((......))))))))))).)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).).....(((((((((.(((....)))..))))).))))......((..(...........)..)).........((((([[....(.((((.....((..]])).......))))))))))..)))))).)))..[......(.([[...(.(.((...(((..(.......................((................))...((((((.(.......((..((.......)).((.(......)))....))......).)))..)))........(.((.(.(((((...............))))).).)).)....)....(((..((..(...((((..(((.((((((((...((........))......)))))))).))).......((....))...))))..)..))...))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.((((......)))))))))).)..)))...((..]]))...))...].))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((...(...((((..((((((((((((.......)))).)))).....))))..))))..).....(((((.....)))))........)))....))).))).....).))))).....).)))))...)).)))).))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..((((.((...(((((....(.....................)......)))))...)).))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}........ Cryo-EM structure of the human 80S ribosome with Tigecycline; 18S rRNA 8k2c CC 75 2.4 RF00005 38942792 0030533 9606 agcagaguggcgcagcggaagcgugcugggcccauaacccagaggucgauggaucgaaaccauccucugcuacca <<<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..(((.....[...))).(((((.......))))).....(((((..]....)))))))))))).... Cryo-EM structure of the human 80S ribosome with Tigecycline; tRNA-Met 8k2d C2 1700 3.2 RF01960,RF02542,RF01959,RF00177 38942792 0003735 0005840 4932 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Cryo-EM structure of the yeast 80S ribosome with tigecycline, eEF2, Stm1 and eIF5A; 18S rRNA 8k2d C1 3188 3.2 RF02543 38942792 0003735 0005840 4932 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Cryo-EM structure of the yeast 80S ribosome with tigecycline, eEF2, Stm1 and eIF5A; 23S rRNA 8k2d C4 121 3.2 RF00001 38942792 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Cryo-EM structure of the yeast 80S ribosome with tigecycline, eEF2, Stm1 and eIF5A; 5S rRNA 8k2d C3 157 3.2 RF00002 38942792 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>.................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....))))))))).................... Cryo-EM structure of the yeast 80S ribosome with tigecycline, eEF2, Stm1 and eIF5A; 5.8S rRNA 8k82 C2 1771 3.0 RF01960,RF02542,RF01959,RF00177 38942792 0003735 0005840 4932 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...<<<<<.{.((((>>>>><<<<.<<<<<<...<.<...<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<..<<..<<....<<<..................<<....<<.<<<.....>>>.>>.....>>.........<<<<<..<<....>>..>>>>><.<.<<<<<<......(((.{((.<<<....>>>..............>>>>>>.>...>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>..>>>..>....>.>.....<<<<<<<<<<<<<....>>>>>>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>>.........<<<[[.....<.<<...<<<.<<....<<<<<<.<<<<..............>>>>.>>>>>>....<<<<<<....................>>>>>>...<<<<<.<<.......<<...<.......>..<<<<...>>>>....>>......>>.>>..>>>.........<<<..<<<<<<<<.....)).}))).>>>>>>>>.>>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..]]>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..)))).}<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<<<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>...>.>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>......<....<<<<<<..........>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<.<<<<.<<<<....>>>>.>>>>.>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>........ ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[[.[[[.(((....))).....(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(((((((.(.(((....))).).)))).)))....(.(((.(...........)).))......)..((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((................))).))))))....((((((....................))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(....(.((.(((.....]].]]]].))).)).)...).....))...(((((((.((...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)).))).)))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(..(((((((.(((..(.((..(...((((((..((((.((((....)))).))))..))))))...)..)).)..))).))))))).)..)).))))...).))...)..)..(((((((((....)))))))))>....... Cryo-EM structure of the yeast 80S ribosome with tigecycline, Not5 and P-site tRNA; 18S rRNA 8k82 C5 75 3.0 RF00005 URS00002CB170_559292 38942792 0030533 0006412 4932 agcgccgunncgcagnggaagcgcncagggcucaunacccugaunnncucggaucgnaaccgagcggcgcuacca <<<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((....[..)))).(((((.......))))).....(((((..]....)))))))))))).... Cryo-EM structure of the yeast 80S ribosome with tigecycline, Not5 and P-site tRNA; tRNA 8k82 C1 3204 3.0 RF02543 38942792 0003735 0005840 4932 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........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..<<<...<.......<<.<<<<<<...>>>>>>.>>.......>.....<<<<<<.<<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<......<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<......>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<.<.....>..>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<.<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<<<<<<<<<<<<..[[[..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>.>.>>>>>>>.>>>>.........>>>>>>..........>.>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<.<<<<<<<<<<<....>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.....<<.....<<<<....>>>>.....>>..>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<..<<<<<<<<<<.<<.<<.<..........<<<<......................>>>>..>>>.>>..>>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))......<<<<<<<..<<<<.))))))>>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>..>>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<....<<<<<<<<<<]]].>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.(((((......(((((((((((((((((((((((.......(((((((......((((((....)))))).......))))))).....))))).))))))))))........(((....)))....)))))))).....))))).))))).<((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))....))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...((((((.....)))))).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((.(.(((....(.........)....))).....(...((......)).)..))))...)))))))))))))..........]]].)....))))))))))...)))))))((((((((...........))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........(((((.(.....)..)))))....))....))...(((((........)))))]]((((..(((.(((...((((....)))...(.[[((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....)))...))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((....)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.((((((((..((((((((.(....(.((..........(..(..(.(...))............)..)..))).....).))))))))....((((.....((((..((((........))))..........]]...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Cryo-EM structure of the yeast 80S ribosome with tigecycline, Not5 and P-site tRNA; 23S rRNA 8k82 C4 121 3.0 RF00001 38942792 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Cryo-EM structure of the yeast 80S ribosome with tigecycline, Not5 and P-site tRNA; 5S rRNA 8k82 C3 158 3.0 RF00002 38942792 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Cryo-EM structure of the yeast 80S ribosome with tigecycline, Not5 and P-site tRNA; 5.8S rRNA 8k85 A 56 2.95 32630 ggagacggucggguccagucgcaacgauguuggcuguugaguagugugugggcucc ........................................................ ........................................................ Crystal structure of Red Broccoli aptamer with OBI; RNA (56-MER) 8k85 B 56 2.95 32630 ggagacggucggguccagucgcaacgauguuggcuguugaguagugugugggcucc ........................................................ ........................................................ Crystal structure of Red Broccoli aptamer with OBI; RNA (56-MER) 8kab A 3111 3.3 RF02541 39029461 0003735 0005840 246196 aaguguuuaagggcgcaugguggaugccuuggcacugggagccgaugaaggacguaggaggcugcgauaagccucggggagcugucaaccgagcguugauccgaggauguccgaauggggaaacccggcacgagugaugucgugucaccaggcgcugaauauauaggcgucuggggggaacgcggggaagugaaacaucucaguacccguaggaagagaaaacaaaaugugauuccgugaguaguggcgagcgaaagcggaggauggcuaaaccguaugcaugugauaccggguagggguugugugugcgggguugugggaccuaucuuuccggcucuaccuggcuggagggcagugagaaaauguugugguuagcggaaauggcuugggauggccugccguagacggugagagcccgguacgugaaaacccgacgucugucuugaugguguucccgaguagcagcgggcccguggaaucugcugugaaucugccgggaccacccgguaagccugaauacuucccagugaccgauagcggauuaguaccgugagggaauggugaaaaguaccccgggaggggagugaaagaguaccugaaaccgugcgcuuacaauccgucagagcccucgacgugucguggggugauggcgugccuuuugaagaaugagccugcgagucagggacaugucgcgagguuaacccgggugggguagccgcagcgaaagcgagucugaauagggcguauccacacaagagugugugguguagugguguguucuggacccgaagcggagugaucuacccauggccagggugaagcgcggguaagaccgcguggaggcccgaacccacuuagguugaagacugaggggaugagcuguggguaggggugaaaggccaaucaaacuccgugauagcugguucuccccgaaaugcauuuaggugcagcgucgcauguuucuugccggagguagagcuacuggauggccgaugggccccacaggguuacugacgucagccaaacuccgaaugccgguaaguccaagagugcggcagugagacggcgggggauaagcuccgugcgucgagagggaaacagcccagaucgccggcuaaggccccuaagcgugugcuaaguggaaaaggaugugcagucgcgaagacaaccaggagguuggcuuagaagcagccacccuugaaagagugcguaauagcucacuggucaagugauugugcgccgauaauguagcggggcucaagcacaccgccgaagccgcggcagccaacguguuggcuggguaggggagcguccugcauccggugaagccgccgagugaucgagugguggagggugugggagugagaaugcaggcaugaguagcgauuaggcaagugagaaccuugcccgccgaaagaccaaggguuccugggccaggccaguccgcccagggugagucgggaccuaaggcgaggccgacaggcguagucgauggacaacggguugauauucccguacccguguaugugcguccaugaugaaucagcgguacuaaccauccaaaaccaccgugaccgcaccuuucgggguguggcguugguggggcugcaugggaccuucguugguaguagucaagcgauggggugacgcaggaagguagccguaccggucagugguaauaccgggguaagccuguagggagucagauagguaaauccgucuggcauauauccugagaggugaugcauagccgagugaggcgaauucggugauccuaugcugccgagaaaagccucuagcgaggacauacacggcccguaccccaaaccaacacagguggucagguagagaauacuaaggcguacgagugaacuaugguuaaggaacucggcaaaaugcccccguaacuucgggagaagggggacccacauggcguguaagccuuuacggcccaagcgugaguggguggcacaaaccagugagaagcgacuguuuacuaaaaacacagguccgugcgaagucgcaagacgauguauacggacugacgccugcccggugcuggaagguuaagaggacccguuaacucccuuugggggugaagcggagaauuuaagccccaguaaacggcggugguacauccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaacgacuucucaacugucucaaccauagacucggcgaaauugcacuacgaguaaagaugcucguuacgcgcggcaggacgaaaagaccccgggaccuucacuacaacuugguauuggugcucgauacgguuuguguaggauaggugggagacugugaagcucacacgccaguguggguggagucguuguugaaauaccacucugaucguauugggccucuaaccucggaccguauauccgguucagggacagugccugguggguaguuuaacuggggcgguugccuccuaaaauguaacggaggcgcccaaagguucccucaaccuggacggcaaucagguguugaguguaagugcacaagggagcuugacugcgagacggacaugucgagcagggacgaaagucgggacuagugauccggcaccucugaguggaaggggugucgcucaacggauaaaagguaccccggggauaacaggcugaucuuccccaagaguccauaucgacgggaugguuuggcaccucgaugucggcucgucgcauccuggggcuggagcaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguuuagaacgucgugagacaguucggucucuauccgccgcgcgcgucagaagcuugaggaaaccugucccuaguacgagaggaccgggacggacgaaccucugguauaccaguugucccaccaggggcacggcuggauagccacguucggacaggauaaccgcugaaagcaucuaagcgggaaaccucuuccaagaccaggcuucucacccucuaggagggauaaggccccccgcagaccacgggauugauagaccagaccuggaagccuaguaauaggugcagggaacuggcacuaaccggccgaaaacuuac 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Mycobacterium smegmatis 50S ribosomal subunit-HflX complex; 23S rRNA 8kab B 118 3.3 RF00001 39029461 0003735 0005840 246196 guuacggcgguccauagcggcagggaaacgcccggucccaucccgaacccggaagcuaagccugccagcgccgaugauacuacccauccggguggaaaaguaggacaccgccgaacac <<<.<<<<<<<.....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<.......<<<<<<....>>>>>>.......>>..>>>>>>>>>>.. (((.(((((((.....((((((((.....((((((...(.....)...))))..))....)))))).)).((.......((((((....)))))).......))..)))))))))).. Mycobacterium smegmatis 50S ribosomal subunit-HflX complex; 5S rRNA 8kag A 98 3.88 RF02348 38811761 301447 gguccguguucuaauugaagguuuuagagcuagaaauagcaaguuaaaauaaggcuaguccguuaucaacuugaaaaaguggcaccgagucggugcuc ....................<<<<<<..<<<<....>>>>....>>>>>>..<<.....>>.......<<<<....>>>>.<<<<<<...>>>>>>.. .....................(((((..((((....))))....)))))...(((..).)).......((((....))))..(((((...)))))... Crystal structure of SpyCas9 in complex with sgRNA and target RNA; RNA (98-MER) 8kag C 20 3.88 38811761 301447 cuucaauuagaacacggacc .................... .................... Crystal structure of SpyCas9 in complex with sgRNA and target RNA; RNA (5'-R(*CP*CP*AP*CP*UP*UP*CP*AP*AP*UP*UP*AP*GP*AP*AP*CP*AP*CP*GP*GP*AP*CP*C)-3') 8kah A 34 3.36 38811761 301447 uuaacgaauuuauggauaaaguuuuagagcuaug .................................. .................................. Crystal structure of SpyCas9-crRNA-tracrRNA complex bound to 18nt target DNA; RNA (34-MER) 8kah E 32 3.36 38811761 301447 aacgaauuuauggauaaaguuuuagagcuaug ................................ ................................ Crystal structure of SpyCas9-crRNA-tracrRNA complex bound to 18nt target DNA; RNA (34-MER) 8kah I 63 3.36 RF02348 38811761 301447 guagcaaguuaaaauaaggcuaguccguuaucaacuugaaaaaguggcaccgagucggugcuu .................<<.....>>.......<<<<....>>>>.<<<<<<...>>>>>>.. .................(((..).)).......((((....))))..((((.....))))... Crystal structure of SpyCas9-crRNA-tracrRNA complex bound to 18nt target DNA; RNA (65-MER) 8kah J 63 3.36 RF02348 38811761 301447 guagcaaguuaaaauaaggcuaguccguuaucaacuugaaaaaguggcaccgagucggugcuu .................<<.....>>.......<<<<....>>>>.<<<<<<...>>>>>>.. .................(((..).)).......((((....))))..(((((...)))))... Crystal structure of SpyCas9-crRNA-tracrRNA complex bound to 18nt target DNA; RNA (65-MER) 8kai A 34 3.49 38811761 301447 uuaacgaauuuauggauaaaguuuuagagcuaug .................................. .................................. Crystal structure of SpyCas9-crRNA-tracrRNA complex bound to 17nt target DNA; RNA (34-MER) 8kai E 31 3.49 38811761 301447 acgaauuuauggauaaaguuuuagagcuaug ............................... ............................... Crystal structure of SpyCas9-crRNA-tracrRNA complex bound to 17nt target DNA; RNA (34-MER) 8kai I 63 3.49 RF02348 38811761 301447 guagcaaguuaaaauaaggcuaguccguuaucaacuugaaaaaguggcaccgagucggugcuu .................<<.....>>.......<<<<....>>>>.<<<<<<...>>>>>>.. .................(((..).)).......((((....))))...(((.....))).... Crystal structure of SpyCas9-crRNA-tracrRNA complex bound to 17nt target DNA; RNA (65-MER) 8kai J 63 3.49 RF02348 38811761 301447 guagcaaguuaaaauaaggcuaguccguuaucaacuugaaaaaguggcaccgagucggugcuu .................<<.....>>.......<<<<....>>>>.<<<<<<...>>>>>>.. .................(((..).)).......((((....))))..((((.....))))... Crystal structure of SpyCas9-crRNA-tracrRNA complex bound to 17nt target DNA; RNA (65-MER) 8kaj A 34 3.42 38811761 301447 uuaacgaauuuauggauaaaguuuuagagcuaug .................................. .................................. Crystal structure of SpyCas9-crRNA-tracrRNA complex bound to 16nt target DNA; RNA (34-MER) 8kaj E 31 3.42 38811761 301447 acgaauuuauggauaaaguuuuagagcuaug ............................... ............................... Crystal structure of SpyCas9-crRNA-tracrRNA complex bound to 16nt target DNA; RNA (34-MER) 8kaj I 63 3.42 RF02348 38811761 301447 guagcaaguuaaaauaaggcuaguccguuaucaacuugaaaaaguggcaccgagucggugcuu .................<<.....>>.......<<<<....>>>>.<<<<<<...>>>>>>.. .................(((..).)).......((((....))))...(((.....))).... Crystal structure of SpyCas9-crRNA-tracrRNA complex bound to 16nt target DNA; RNA (65-MER) 8kaj J 63 3.42 RF02348 38811761 301447 guagcaaguuaaaauaaggcuaguccguuaucaacuugaaaaaguggcaccgagucggugcuu .................<<.....>>.......<<<<....>>>>.<<<<<<...>>>>>>.. .................(((..).)).......((((....))))..(((((...)))))... Crystal structure of SpyCas9-crRNA-tracrRNA complex bound to 16nt target DNA; RNA (65-MER) 8ki7 F 13 3.7 32630 accugauugcucu ............. ............. Structure of Tomato spotted wilt virus L protein contained endoH domain binding to 3'5'vRNA; RNA (5'-R(P*AP*CP*CP*UP*GP*AP*UP*UP*GP*CP*UP*CP*U)-3') 8oeq 1 3217 3.3 RF02540,RF02541,RF02543 0003735 0005840 5476 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.......................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........(((((...((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))).)..))))))))....))))..)))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((((((..(..((((...((.......))...))))).((((((((((((((((.(((((((........((((((......((((((......)))))).......))))))......))))).))))))))))........(((..)))....))))))))....)))))))))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..((((....))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((....((.(((((((.....(((....(((..(.((((...((((.........)))).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.......(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((..((.........))..)))))....))))))(.((((((((.((......((((..(((....))).))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........(.((.((......)).))).....))....))...(((((........)))))]]((((..(((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((......)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..((((((((((....(.(.............(...(......)...............)...)..)...))))))))))....((((.....((((..(((((......)))))...........>..((((...))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.............))))...)))).))))....)))))))).....((((((.(((.......((.(........((((..)))).....))).......((((((...(((((((..(((......)))..))))))).))))))................))).))))))..(((((((..(.......)..))..(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Crystal structure of the Candida albicans 80S ribosome in complex with Paromomycin (250uM); 25S ribosomal RNA 8oeq 3 121 3.3 RF00001 0003735 0005840 5476 gguugcggccauaucuagcagaaagcaccguuccccguucgaucaaccguaguuaagcugcuaagagcaauaccgaguaguguagugggagaccauacgcgaaacuauugugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of the Candida albicans 80S ribosome in complex with Paromomycin (250uM); 5S ribosomal RNA 8oeq 4 157 3.3 RF00002 URS0000082EA4_5476 0003735 0005840 5476 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaauaugaauugcagauauucgugaaucaucgaaucuuugaacgcacauugcgcccucugguauuccggagggcaugccuguuugagcgucguu .........................................<<<<<<.((.....>>>.....<.<<<<.....))............>>.>>..>...>>>....<<.....>><<<<<<<<<....>>>>>>>>>.................... .........................................((((((.[[.....))).....(.((((.....]]............)).))..)...)))....((.....))(((((((((....))))))))).................... Crystal structure of the Candida albicans 80S ribosome in complex with Paromomycin (250uM); 5.8S ribosomal RNA 8oeq B 1712 3.3 RF01960,RF02542,RF01959,RF00177 0003735 0005840 5476 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguacuacuuggauaaccgugguaauucuagagcuaauacaugcuuaaaaucccgacuguuuggaagggauguauuuauuagauaaaaaaucaaugccuucgggcucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaaucccgacacggggagguagugacaauaaauaacgauacaggguuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaaaagcguauauuaaaguuguugcaguuaaaaagcucguaguugaaccuugggcuuggcuggccgguccuggacccagccgagccuuuccuucuggccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggccuuugcucgaauauauuagcauggaauaauagaauaggacguuaugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucggggguaucaguauucaguugucagaggugaaauucuuggauuuacugaagacuaacuacugcgaaagcauuuaccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgguuguuguucuuuuauugacgcaaucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauagugcugcuagcauuugcugguauagucacuucuuagagggacuaucgauuucaagucgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgaguauaagccuuggccgagaggucugggaaaucuugugaaacuccgucgugcuggggauagagcauuguaauuguugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuacuaccgauugaauggcuuagugaggccuccggauugguuuagggaaccgagaagcuggucaaacuuggucauuuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucau 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....(((..[.[[[..))).((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..........((.....(..(((.....)))..)......))........(((((..((....))..)))))(.(.(((((........[[.[[..(((....))).....(......)..))))).)...).(..(((..((((..).))).))).)...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(((...(......)..)))......(.(.(...........))..).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((((((((............))))))))))))....(((((..)))))...(((((.((.......((..((.......)).(((....)))....))......)).))..))).........(((..(((((.((.......]]..]]..)).)))))))).....))....((..((.((...((((...((.((((((.....((........))........)))))).))........((....))...))))..)).))...))...)))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((..(..........).))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.........(.(((........))).).......)))))...((.(((...(..((((.....(((.(((((....)))..(.((......)))...)).)))....(((((.((...(((..((((.(.(((((....))))).)....))))..)))..))..(.((((((.....))))))....)..))))).....)).))......).))))).....).)))))...)).)))).))).(...(((((((......((......(((.((((....)))).)))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..((((..(...(.((..(....).)).)...)..))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>...... Crystal structure of the Candida albicans 80S ribosome in complex with Paromomycin (250uM); 18S ribosomal RNA 8oeq AS 3199 3.3 RF02540,RF02541,RF02543 0003735 0005840 5476 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Crystal structure of the Candida albicans 80S ribosome in complex with Paromomycin (250uM); 25S ribosomal RNA 8oeq AT 121 3.3 RF00001 0003735 0005840 5476 gguugcggccauaucuagcagaaagcaccguuccccguucgaucaaccguaguuaagcugcuaagagcaauaccgaguaguguagugggagaccauacgcgaaacuauugugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<<............>>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of the Candida albicans 80S ribosome in complex with Paromomycin (250uM); 5S ribosomal RNA 8oeq AU 158 3.3 RF00002 0003735 0005840 5476 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaauaugaauugcagauauucgugaaucaucgaaucuuugaacgcacauugcgcccucugguauuccggagggcaugccuguuugagcgucguuu .........................................<<<<<<.((.....>>>.....<.<<<<.....))............>>.>>..>...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............)).))..)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of the Candida albicans 80S ribosome in complex with Paromomycin (250uM); 5.8S ribosomal RNA 8oeq CM 1726 3.3 RF01960,RF02542,RF01959,RF00177 0003735 0005840 5476 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....(((..[.[[[..))).((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((.........((.....(..(((.....)))..)......)).........((((..((....))..)))).(.(.(((((.........[.[[[.(((....))).....(......)..))))).)...).(..(((...(((..).))..))).)...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....((((..(......).))))......(.(.(...........))..).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((((((((............))))))))))))......((......................)).....(((((.((.(.....((..((.......)).(((....)))....))..)...)).))..))).........(((..(((((.((......]]]...]..)).)))))))).....))....((..((..(...((((...(..((((((.....((........))........))))))..)........((....))...))))..)..))...))...)))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((..((........)).))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))........(.(((((.(....(((((.........(.(((........))).).......)))))...((.(((...(..((((.....(((.(((((....)))..(.((......)))...)).)))....(((((.((...(((..((((.(.(((((....))))).)....))))..)))..))..(.((((((.....))))))....)..))))).....)).))......).))))).....).))))))..)).)))).))).(...(((((((......((...(((.((((....)))).)))....)).......)))))))......(....((((((..........))))))....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..((((..(...((((.........))))...)..))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>...... Crystal structure of the Candida albicans 80S ribosome in complex with Paromomycin (250uM); 18S ribosomal RNA 8ogj 1 3126 3.1 RF02540,RF02541,RF02543 0003735 0005840 5476 ugaccucaaaucagguaggacuacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaacagggauugccucaguagcggcgagugaagcggcaaaagcucaaauuugaaaucuggcgucuuuggcguccgaguuguaauuugaagaagguaucuuugggcccggcucuugucuauguuccuuggaacaggacgucacagagggugagaaucccgugcgaugagaugacccgggucuguguaaaguuccuucgacgagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcuugagaucagacuugguaccgggccagcaucgguuuggagcggcaggauaauggcggaggaauguggcacggcuucugcuguguguuauagccucugacgauacugccagccuagaccgaggacugcgguuuuuaccuaggauguuggcauaaugaucuuaagucgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccguacgcguaaugaaagugaacgaaggugggggcccauuagggugcaccaucgaccgauccugauguguucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagaagucuugggcuuaacuuauucucaaacuuuaaauauguaagaaguccuuguugcuuaauugaacguggacaauugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacgugaaguuaaagugccggaaugcacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcgugcuacuuauacuucaccgugauugcuguuuugacgcuuucacgaguaggcaggcguggaggucagugacgaagccuuugcuguaaagcugggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccaugucaacagcaguuggacauggguuagucgauccuaagagauggggaagcuccguuucaacgugcuugauuuuucaggccaaccaucgaaagggaauccgguuaaaauuccggaacuuggauauggauucuucacggcaacguaacugaauguggagacgucggcgugagcccugggaggaguuaucuuuucuucuuaacagcuuaucacccuggaauugguuuauccggagauggggucuuauggcuggaagagcgcgguaauuuugccgcguccggugcgcuuacgacgguccuugaaaauccacaggaaggaauaguuuucaugccaagucguacucauaaccgcagcaggucuccaagguuaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaaggaucgguaacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugugauggucagaaagugauguugacacaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaaaaguuuuuacuuauucaaugaagcggagcuggaggucaaacuccacguucuagcauuaagcccucugggcgauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagguguccuaagggggacucauggagaacagaaaucuccaguagaacaaaaggguaaaaguccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaucgcaauaguaauugaacuuaguacgagaggaaccguucauucagauaauugguuuuugcggcugucugaucaggcaacgccgcgaagcuaccaucugcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcgaugauuuuugcccugcacauuuuagauggauacgaauaagacuuuuuagucgcuggaccauagcaggcuggcaacggugcgcuuagcggaaaggcuuugugcgcuugccggcggauagcaaugucaacaugcgcggggauaaauccuuugcauacgacuuagauguacaacggaguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagcucuuguugucugauuugu .......................<<<<<<.....<......>......>>>>>.>...{.....<<....>>..<<<<<......<<.....>>.....>>>>>..[[[...<.......<<.<<<<<<...>>>>>>.>>.......>.....<<<<<...<<<<<<<<<<<<.<<<<<<<.....<<<<......>>>>.(.......<<<......)>>>....>>>>>>>....>>>>>>>>....>>>>..>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]....}.............................<<....>>...............<<<<....>>>>..................................<<<<<<<<<<<<.....<<..>>..<<<<<<<.<<<<<<<<.<<<<<<<....<<.<<<<<<<......<<<<<<......>>>>>>.......>>>>>>.>.>>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<..<<<<<.....>>>>>..>>>...<<....>>.......<<<<<..<<<<....>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<..>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<..<<.........>>..>>>>>....>>>>>>..<<<<<<<<.<<......<<<<..<<<....>>>.>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<<<<<....>>>>>>......>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<....>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<.>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>..............<<<<...>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<.<.<<<<<.................>>>>>.><<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.....<<<<<<.<<<.<.....<<..........<<<<....>>>>......>>.......<<<<<<...<<<<<<<..<<<......>>>..>>>>>>>.>>>>>>..............>.>>>.>>>>>>..<<<<<<<.............>>....<<<<<<<<<.<<<....<<<<.<..<<<<<......>>>>>..>>>>>...>>>....>>>>.>>>>>..>>>>>.. .......................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........(((((...((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))).)..))))))))....))))..)))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((((((..(..((()))).((((((((((((((((.(((((((........((((((......((((((......)))))).......))))))......))))).))))))))))........(((....)))....))))))))....)))))))))))).[((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..((((....))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((((((((((....((.(((((((.....(((....(((..(.((((....(())..)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{..((((..(....((.........))....)......(...((......)).).))))....)))))))))))))..........]]].)....))))))))))...)))))))(((((..((.........))..)))))....))))))(.((((((((.((......((((..(((....))).))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........(.((.((......)).))).....))....))...(((((........)))))]]((((..(((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((.(....).)))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((....)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.)))))))...(((((.....((((..(((((......)))))...........>..((((...))))..))))..))))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).....((((((.(((..(....((.(........((((....)))).....))).......((((((...(((((((..(((......)))..))))))).)))))).............)..))).))))))..(((((((..(.......)..))..(.(((((((((.(((....((((.(..(((.((..)..).)))..)))))...)))....)))).)))))).))))).. Structure of Candida albicans 80S ribosome in complex with mefloquine; 25S ribosomal RNA 8ogj 3 121 3.1 RF00001 0003735 0005840 5476 gguugcggccauaucuagcagaaagcaccguuccccguucgaucaaccguaguuaagcugcuaagagcaauaccgaguaguguagugggagaccauacgcgaaacuauugugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Structure of Candida albicans 80S ribosome in complex with mefloquine; 5S ribosomal RNA 8ogj 4 158 3.1 RF00002 0003735 0005840 5476 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaauaugaauugcagauauucgugaaucaucgaaucuuugaacgcacauugcgcccucugguauuccggagggcaugccuguuugagcgucguuu .........................................<<<<<<.((.....>>>.....<.<<<<.....))............>>.>>..>...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.(((......]].............).))..)...)))....((.....))(((((((((....)))))))))..................... Structure of Candida albicans 80S ribosome in complex with mefloquine; 5.8S ribosomal RNA 8ogj 10 14 3.1 RF00005 URS0000D22C51_237561 0030533 0006412 5476 ggcagcugcuacca <<<<..>>>>.... .(((())))..... Structure of Candida albicans 80S ribosome in complex with mefloquine; Mixture of endogenous E-tRNAs 8ogj A 1674 3.1 RF01960,RF02542,RF01959,RF00177 0003735 0005840 5476 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguauacuuggauaaccgugguaauucuagagcuaauacaugcuuaaaaucccgacuguuuggaagggauguauuuauuagauaaaaauuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaaucccgacacggggagguagugacaauaaauaacgauacagguuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaaaagcguauauuaaaguuguugcaguuaaaaagcucguaguugaaccuugggcuuggcgccgagccuuuccuucuggccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggccuuugcucgaauauauuagcauggaauaauagaauaggacguuaugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucggggguaucaguauucaguugucagaggugaaauucuuggauuuacugaagacuaacuacugcgaaagcauuuaccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgguuguuguucuuuuauugacgcaaucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauagugcugcuagcauuugcugguauagucacuucuuagagggacuaucgauuucaagucgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgaguauaagccuuggccgagaggucugggaaaucuugugaaacuccgucgugcuggggauagagcauuguaauuguugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuacuaccgauugaauggcuuagugaggccuccggauugguuuagggaaccgagaagcuggucaaacuuggucauuuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucau ...<<<<<.[.((((>>>>><<<<.<<<<<<...<.<...<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<..<<..<<....<<<.........<<.....<..<<.......>>..>......>>........<<<<<..<<....>>..>>>>><...<<<<<<......[.............>>>>>>.....>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>....>.>.....<<<<...<..>...>>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>>.........<<<((.....<.<<...<<<.<<....<<<<<<<<..>>>>>>>>....<<<<<..>>>>>...<<<<<.<<.......<<...<.......>..<<<....>>>....>>......>>.>>..>>>.........<<<..<<<<<<<<<...........].>>>>>>>>>>>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<..<<........>>.>>>>>>>>..>>>...<<..))>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<.....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<.<<<<<<<....>>>>>>>....>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>.....>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<......<<<.<<<<....>>>>.>>>....>>.......>>>>>>>......<....<<<<<<..........>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<..<...<<<<.<<....>>>>>>...>..>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>....... ....(((..[.[[[..))).((((.((((((...(.(...((.....(((.(((..((....((....((..........))...))[))......(((.......(((..((..((....(((.........((.....(..(((.....)))..)......))........(((((..((....))..)))))(.(.(((((.......{{...(......)..))))).)...).(..(((.(((((..).))))))).)...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)....).).....((((..(.()..).))))......(.(.(...........))..).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..[......((([[...(.(.((...(((.((....((((((((()))))))))....(((((..)))))...(((((.((.(.....((..((.......)).(((....)))....))..)...)).))..))).........(((..(((((.(((..........}}.))).)))))))).....))....((..((..(...((((...(..((((((.....((........))........))))))..)........((....))...))))..)..))...))...)))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..((((((((..(..........).))))))))..)))...((..]]))...))...].))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.........(.(((........))).).......)))))...((.(((...(..((((.....(((.(((((....)))..(.((......)))...)).)))....(((((.((...(((..((((.(.(.(((....))).).)....))))..)))..))..(.((((((.....))))))....)..))))).....)).))......).))))).....).)))))...)).)))).))).(...(((((((......((......(((.((((....)))).)))....)).......)))))))......(....((((((..........))))))....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..((((..(...((((.........))))...)..))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}...... Structure of Candida albicans 80S ribosome in complex with mefloquine; 18S ribosomal RNA 8oh6 1 3219 3.35 RF02540,RF02541,RF02543 0003735 0005840 5476 ugaccucaaaucagguaggacuacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaacagggauugccucaguagcggcgagugaagcggcaaaagcucaaauuugaaaucuggcgucuuuggcguccgaguuguaauuugaagaagguaucuuugggcccggcucuugucuauguuccuuggaacaggacgucacagagggugagaaucccgugcgaugagaugacccgggucuguguaaaguuccuucgacgagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcuugagaucagacuugguauuuugcaugcugcgguuuaccgggccagcaucgguuuggagcggcaggauaauggcggaggaauguggcacggcuucugcuguguguuauagccucugacgauacugccagccuagaccgaggacugcgguuuuuaccuaggauguuggcauaaugaucuuaagucgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccguacgcguaaugaaagugaacgaaggugggggcccauuagggugcaccaucgaccgauccugauguguucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagaagucuugggguugaaaugaccuuaacuuauucucaaacuuuaaauauguaagaaguccuuguugcuuaauugaacguggacaauugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacgugaaguuaaagugccggaaugcacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcgugcuacuuauacuucaccgugauugcuguuuugacgcuuucacgaguaggcaggcguggaggucagugacgaagccuuugcuguaaagcugggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccaugucaacagcaguuggacauggguuagucgauccuaagagauggggaagcuccguuucaacgugcuugauuuuucaggccaaccaucgaaagggaauccgguuaaaauuccggaacuuggauauggauucuucacggcaacguaacugaauguggagacgucggcgugagcccugggaggaguuaucuuuucuucuuaacagcuuaucacccuggaauugguuuauccggagauggggucuuauggcuggaagagcgcgguaauuuugccgcguccggugcgcuuacgacgguccuugaaaauccacaggaaggaauaguuuucaugccaagucguacucauaaccgcagcaggucuccaagguuaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaaggaucgguuuaacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugugauggucagaaagugauguugacacaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaaaagacauggaggguguagaauaagugggagcuucggcgccggugaaauaccacuaccucuauaguuuuuuuacuuauucaaugaagcggagcuggaggucaaacuccacguucuagcauuaagcccucugggcgauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagguguccuaagggggacucauggagaacagaaaucuccaguagaacaaaaggguaaaaguccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaucgcaauaguaauugaacuuaguacgagaggaaccguucauucagauaauugguuuuugcggcugucugaucaggcaacgccgcgaagcuaccaucugcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcgaugauuuuugcccugcacauuuuagauggauacgaauaagacuuuagucgcuggaccauagcaggcuggcaacggugcgcuuagcggaaaggcuuugugcgcuugccggcggauagcaaugucaacaugcgcggggauaaauccuuugcauacgacuuagauguacaacggaguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagcucuuguugucugauuugu .......................<<<<<<.....<<....>>......>>>>>.>...{.....<<....>>..<<<<<......<<.....>>.....>>>>>..[[[...........<<.<<<<<<...>>>>>>.>>.............<<<<<...<<<<<<<<<<<<.<<<<<<<.....<<<<......>>>>.(.......<<<......)>>>....>>>>>>>....>>>>>>>>....>>>>..>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]....}.............................<<....>>...............<<<<....>>>>..................................<<<<<<<<<<<<.....<<<<.<.<<<<...>>>>>..>>>>..<<<<<<<.<<<<<<<<.<<<<<<<....<<.<<<<<<<......<<<<<<......>>>>>>.......>>>>>>.>.>>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<..<<<<<.....>>>>>..>>>...<<....>>.......<<<<<..<<<<....>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<..<<.........>>..>>>>>....>>>>>><.<<<<<<<<.<<......<<<<..<<<....>>>.>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<<<<<....>>>>>>......>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<.<<<<<<<<<<<......>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<<<<.<.<<<..........................................>>>.>>>.>>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>..............<<<<...>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<.<.<<<<<.................>>>>>.><<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.....<<<<<<.<<<.......<<..........<<<<..>>>>......>>.......<<<<<<...<<<<<<<..<<<......>>>..>>>>>>>.>>>>>>................>>>.>>>>>>..<<<<<<<.............>>....<<<<<<<<<.<<<....<<<<.<..<<<<<......>>>>>..>>>>>...>>>....>>>>.>>>>>..>>>>>.. .......................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........(((((...((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))).)..))))))))....))))..)))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((((((..(..(((...................)))).((((((((((((((((.(((((((........((((((......((((((......)))))).......))))))......))))).))))))))))........(((....)))....))))))))....)))))))))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..((((....))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((....((.(((((((.....(((....(((..(.((((...((((.(.....).)))).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.......(((((.((....((.........))....)).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((..((.........))..)))))....))))))(.((((((((.((......((((..(((....))).))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........(.((.((......)).))).....))....))...(((((........)))))]]((((..(((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((......)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(..(((.....((((....)))).....))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..((((((((.(...(..((......[.....(...(......)..........]....)..))..)...).))))))))....((((.....((((..(((((......)))))...........>..((((...))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.............))))...)))).))))....)))))))).....((((((.(((.......((.(........((((..)))).....))).......((((((...(((((((..(((......)))..))))))).))))))................))).))))))..(((((((..(.......)..))..(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Crystal structure of the Candida albicans 80S ribosome in complex with Paromomycin (500umol); 25S (gene name XR_002086444.1) 8oh6 3 121 3.35 RF00001 0003735 0005840 5476 gguugcggccauaucuagcagaaagcaccguuccccguucgaucaaccguaguuaagcugcuaagagcaauaccgaguaguguagugggagaccauacgcgaaacuauugugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of the Candida albicans 80S ribosome in complex with Paromomycin (500umol); 5S 8oh6 4 157 3.35 RF00002 URS0000082EA4_5476 0003735 0005840 5476 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaauaugaauugcagauauucgugaaucaucgaaucuuugaacgcacauugcgcccucugguauuccggagggcaugccuguuugagcgucguu .........................................<<<<<<.((.....>>>.....<.<<<<.....))............>>.>>..>...>>>....<<.....>><<<<<<<<<....>>>>>>>>>.................... .........................................((((((.[[.....))).....(.((((.....]]............)).))..)...)))....((.....))(((((((((....))))))))).................... Crystal structure of the Candida albicans 80S ribosome in complex with Paromomycin (500umol); 5.8S 8oh6 B 1730 3.35 RF01960,RF02542,RF01959,RF00177 0003735 0005840 5476 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguacuacuuggauaaccgugguaauucuagagcuaauacaugcuuaaaaucccgacuguuuggaagggauguauuuauuagauaaaaaaucaaugccuucgggcucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaaucccgacacggggagguagugacaauaaauaacgauacaggguuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaaaagcguauauuaaaguuguugcaguuaaaaagcucguaguugaaccuugggcuuggcuggccgguccuggacccagccgagccuuuccuucuggguagccauuuauggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggccuuugcucgaauauauuagcauggaauaauagaauaggacguuaugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucggggguaucaguauucaguugucagaggugaaauucuuggauuuacugaagacuaacuacugcgaaagcauuuaccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgguuguuguucuuuuauugacgcaaucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauagugcugcuagcauuugcugguauagucacuucuuagagggacuaucgauuucaagucgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgaguauaagccuuggccgagaggucugggaaaucuugugaaacuccgucgugcuggggauagagcauuguaauuguugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuacuaccgauugaauggcuuagugaggccuccggauugguuuagggaaccgagaagcuggucaaacuuggucauuuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucau ...<<<<<...((((>>>>><<<<.<<<<<<...<.<...<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<..<<..<<....<<<..........<<.....<..<<<.....>>>..>......>>........<<<<<..<<....>>..>>>>><...<<<<<<......[[[.((((<<<....>>>..............>>>>>>.....>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>....>.>.....<<<<...<...>...>>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>>.........<<<{{.....<.<<...<<<.<<....<<<<<<<<<<<<............>>>>>>>>>>>>.....<<<<....................>>>>....<<<<<.<<.......<<...<.......>..<<<....>>>....>>......>>.>>..>>>.........<<<..<<<<<<<<<....)))).]]].>>>>>>>>>>>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<..<<........>>.>>>>>>>>..>>>...<<..}}>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..))))..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<.....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<.<<<<<<<....>>>>>>>....>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>.....>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<......<<<.<<<<....>>>>.>>>....>>.......>>>>>>>......<....<<<<<<..........>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<..<...<<<<.........>>>>...>..>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>....... ....(((..[.[[[..))).((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..........((.....(..(((.....)))..)......))........(((((..((....))..)))))(.(.(((((........[[.[[..(((....))).....(......)..))))).)...).(..(((..((((..).))).))).)...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....((((..(......).))))......(.(.(...........))..).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((((((((............)))))))))))).....((((....................))))....(((((.((.(.....((..((.......)).(((....)))....))..)...)).))..))).........(((..(((((.(((......]].]]..))).)))))))).....))....((..((..(...((((...((.((((((.....((........))........)))))).))........((....))...))))..)..))...))...)))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((..(..........).))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.........(.(((........))).).......)))))...((.(((...(..((((.....(((.(((((....)))..(.((......)))...)).)))....(((((.((...(((..((((.(.(((((....))))).)....))))..)))..))..(.((((((.....))))))....)..))))).....)).))......).))))).....).)))))...)).)))).))).(...(((((((......((......(((.((((....)))).)))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..((((..(...((((.........))))...)..))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>...... Crystal structure of the Candida albicans 80S ribosome in complex with Paromomycin (500umol); 18S 8oh6 AS 3061 3.35 RF02540,RF02541,RF02543 0003735 0005840 5476 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.......................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[...........<<.<<<<<<...>>>>>>.>>.............<<<<<...<<<<<<<<<<<<.<<<<<<<.....<<<<......>>>>.(.......<<<......)>>>....>>>>>>>....>>>>>>>>....>>>>..>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<<<<<.....<<.<........>.>>..<<<<<<<.<<<<<<<<.<<<<<<<....<<.<<<<<<<......<<<<<<......>>>>>>.......>>>>>>.>.>>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<..<<<<<.....>>>>>..>>>...<<....>>.......<<<<<..<<<<....>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<.......>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<.>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<..<<.........>>..>>>>>....>>>>>><.<<<<<<<<.<<......<<<<..<<<....>>>.>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<<..>>>......>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<.<<<<<<<<<<<...>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<..>>>>>...<<<<<.....<<<<..<<<<<.>>>>>..............<<<<...>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<.<.<<<<<.................>>>>>.><<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.....<<<<<<.<<<.......<<..........<<<<....>>>>......>>.......<<<<<<...<<<<<<<..<<<......>>>..>>>>>>>.>>>>>>................>>>.>>>>>>..<<<<<<<.............>>....<<<<<<<<<.<<<....<<<<.<..<<<<<......>>>>>..>>>>>...>>>....>>>>.>>>>>..>>>>>.. .......................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........(((((...((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))).)..))))))))....))))..)))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((((((..(..((.(........).))).((((((((((((((((.(((((((........((((((......((((.(......).)))).......))))))......))))).))))))))))........(((....)))....))))))))....)))))))))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..((((....))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((....((.(((((((.....(((....(((..(.((((...(((((.......))))).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.(((((((((.))))))))))))..........]]].)....))))))))))...)))))))(((((..((.........))..)))))....))))))(.((((((((.((......((((..(((....))).))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........(.((....))).....))....))...(((((........)))))]]((((..(((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((...)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(..(((.....((((....)))).....))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((())))))....((((.....((((..(((((.)))))...........>..((((...))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.............))))...)))).))))....)))))))).....((((((.(((.......((.(........((((....)))).....))).......((((((...(((((((..(((......)))..))))))).))))))................))).))))))..(((((((..(.......)..))..(.(((((((((.(((....((((.(..(((.((..)..).)))..)))))...)))....)))).)))))).))))).. Crystal structure of the Candida albicans 80S ribosome in complex with Paromomycin (500umol); 25S (gene name XR_002086444.1) 8oh6 AT 121 3.35 RF00001 0003735 0005840 5476 gguugcggccauaucuagcagaaagcaccguuccccguucgaucaaccguaguuaagcugcuaagagcaauaccgaguaguguagugggagaccauacgcgaaacuauugugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<<............>>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of the Candida albicans 80S ribosome in complex with Paromomycin (500umol); 5S 8oh6 AU 156 3.35 RF00002 0003735 0005840 5476 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaauaugaauugcagauauucgugaaucaucgaaucuuugaacgcacauugcgcccucugguauuccggagggcaugccuguuugagcgucgu .........................................<<<<<<.((.....>>>.....<.<<<<.....))............>>.>>..>...>>>....<<.....>><<<<<<<<<....>>>>>>>>>................... .........................................((((((.[[.....))).....(.((((.....]]............)).))..)...)))....((.....))(((((((((....)))))))))................... Crystal structure of the Candida albicans 80S ribosome in complex with Paromomycin (500umol); 5.8S 8oh6 CM 1704 3.35 RF01960,RF02542,RF01959,RF00177 0003735 0005840 5476 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguauacuuggauaaccgugguaauucuagagcuaauacaugcuuaaaaucccgacuguuuggaagggauguauuuauuagauaaaaaaucaaugccuucgggcucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaaucccgacacggggagguagugacaauaaauaacgauacagggguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaaaagcguauauuaaaguuguugcaguuaaaaagcucguaguugaaccuugggcuuggcuggccgguccuggacccagccgagccuuuccuucuggguaggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggccuuugcucgaauauauuagcauggaauaauagaauaggacguuaugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucggggguaucaguauucaguugucagaggugaaauucuuggauuuacugaagacuaacuacugcgaaagcauuuaccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgguuguuguucuugacgcaaucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauagugcugcuagcauuugcugguauagucacuucuuagagggacuaucgauuucaagucgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgaguauaagccuuggccgagaggucugggaaaucuugugaaacuccgucgugcuggggauagagcauuguaauuguugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuacuaccgauugaauggcuuagugaggccuccggauuggucgagaagcuggucaaacuuggucauuuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucau ...<<<<<.{.[[[[>>>>><<<<.<<<<<<...<.<...<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<..<<..<<....<<<.........<<.....<..<<.......>>..>......>>........<<<<<..<<....>>..>>>>><...<<<<<<.......((((((..<<....>>...............>>>>>>.....>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>....>.>.....<<<<.........>>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>>.........<<<[[.....<.<<...<<<.<<....<<<<<<<<<<<<............>>>>>>>>>>>>.....<<<.............>>>....<<<<<.<<.......<<...<.......>..<<<....>>>....>>......>>.>>..>>>.........<<<..<<<<<<<<<.....))))))..>>>>>>>>>>>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<..<<...>>.>>>>>>>>..>>>...<<..]]>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..]]]].}<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<.....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<.<<<<<<<....>>>>>>>....>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>.....>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<......<<<.<<<<....>>>>.>>>....>>.......>>>>>>>......<....<<<<<<..........>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<..<...<<<..>>>...>..>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>....... ....(((..[.[[[..))).((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((.........((.....(..(((.....)))..)......))........(((((..((....))..)))))(.(.(((((.........[.[[[..((....))......(......)..))))).)...).(..(((..((((..).))).))).)...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....((((..(....).))))......(.(.(...........))..).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....(((((((((((..............)))))))))))......(((...........))).....(((((.((.......((..((.......)).(((....)))....))......)).))..))).........(((..(((((.(((.....]]]...].))).)))))))).....))....((..((..(...((((...(..((((((.....((........))........))))))..)........((....))...))))..)..))...))...)))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((..(.....).))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.........(.(((........))).).......)))))...((.(((...(..((((.....(((.(((((....)))..(.((......)))...)).)))....(((((.((...(((..((((.(.(((((....))))).)....))))..)))..))..(.((((((.....))))))....)..))))).....)).))......).))))).....).)))))...)).)))).))).(...(((((((......((......(((.((((....)))).)))....)).......)))))))......(....((((((..........))))))....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(.(((((.((.(((..((((..(...(((..)))...)..))))..))).)).))))))..)).))))...).))...)..)..(((((((((....)))))))))>...... Crystal structure of the Candida albicans 80S ribosome in complex with Paromomycin (500umol); 18S 8ohd 5 3474 3.1 RF02543 38383785 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccgcuccccggcggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucgggggcccccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcgcucuccccccggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccggggggccacgcgcgcgucccccgggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgccggccgaggugggaucccgaggccucuccaguccgccgagggcgcaccaccggcccgucucgcgggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcagacccgacgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcgccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgcccucggccgaucgaaagggagucggguucagauccccgaauccggagcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcugguagcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacaugagagguguagaauaagugggaggcccgccggugaaauaccacuacucugauguuuuuucacugacccggugaggcgggggggcgaucucgcuucuggcgccaagcgcccggccgcggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccgguccccgggguccggugcggagugcccuucguccugggaaacggggcgcggcuggaaaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>>..<<<<<<<<<<...<<<<<<.<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>.....>>>>>>..>>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<......>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<<<..<<<<<<<...>>>>...>>>>>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<.<<<<<<<<<<<<<<<...<<..<<<..<.<<<<......<<<<<<<<..>>>>>>>>.......>>>>.>.>>>........>>>>>>..>>>>>>>>>>>....................<<<<<<.<<<<<..>>>>>.<<<<<<.<<<<.<<<<<<<<<<<<<<<<<<<<<<<<.<<<<....>>>>.>>>>>>>>>>>.>>>>>>>>>>.>>>...>>>>>>>>.>>..<<<<<<<<<..>>>>>>>.>>....>>>>>>......>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<..>>>>>>..<<<<<...<<<..<<<..((((.((((>>>..>>>....>>>>>.<<<<<<<<<....>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<.............<<<.<<<<<<<<<...<<<....<<<..<.<<<..<<<<<<.<<...>>.>>>>>>>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<..>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<..........)))).))))...............>>>>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<..>>>>>......>>....>>>..<<<<<........>>>>>))<<<<.<<<<<..<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<....>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<....<<<<<....>>>>.>...>>>.>>>>..>>>>><<<<<..>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<<<<<<.<<<<...........<..<<..................>>..>.>>>>.>>>>>>>>>>>>...<<<<<.....<<<<..<<.<..>>>..............<<<<<<<<<<..>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>>.<<<....>>>.>>)))].....<<<<<<<..<<<..)))))).>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<]]].>>>>>..>>.>>...>>>>...>>>><<<<....<<<<<...........>>>>>....>>>>.>>>...>.>>>>>>.....<<<<<<<.<<..<<<<....<<<........<<<<<.<<<<>>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>..............>>>>..>>>>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<.<..<<<<..>>>>..>>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((...((((((((((.....)))))).)))).....)))....((((((((((...(((((.(((((((((..({((((......)))))....[[(...).(((....}]])))...).)))))))....).)))))..))))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....(((((((((((..(((((((.()))))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((..(.((((......((((((((())))))))).......)))).).)))........))))))..)))))))))))....................((((((.(((((()))))).((((((.((((.(((((((((((((((((.(((((..((((....))))..))))).)))).)))))))))).)))...)))))))).))..(((((((((()))))))).))..[.)))))).....))).)))))...)))))...)))))))).<((((........))))((((((....(((((((((((((..(((..(((((........))))..)..)))...((....))...((((((()))))))..(((((...(((..(((..[[[[.[[[[)))..)))....))))).(((((((((.().))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((.............(((.((((((((....(((....(((..(.(((..((((((.(.....).))))))))).)..)))..)).)....))))))...(((((((((.(......))))))))))....))))))))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.....{.(())...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((..........]]]].]]]]].(...)........)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...((....(((....)))..........((.(((())))))......))....))...(((((........)))))]]((((.(((((...(((((((....)))))))..((((....)))...(...((((((...(((((((((((((((((((((((..{{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((....)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((())))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.(((((((((.((((((((((((.((((...........(.(((..................)).)).)))).))))))))))))...(((((.....((((..(..(..).)..............((((((((((()))))))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a.))..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}}.)))))..)).))...))))...)))).((((...((((.....}.......))))...))))..)))...).)))))).....(((((((.((..((((.(..(((........(((((.(((()))).))))).......)))...(((..((((....((((.(((((.(......).)))))))))...))))..)))...........)..))))..)))))))))(((((.(..(.......)..)....((.(((((((.((.....((((.(..((((()))))..)))))....))....)))).))).))..))))).. 60S ribosomal subunit bound to the E3-UFM1 complex - state 3 (native); 28S rRNA 8ohd 7 120 3.1 RF00001 38383785 0003735 0005840 9606 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. 60S ribosomal subunit bound to the E3-UFM1 complex - state 3 (native); 5S rRNA 8ohd 8 148 3.1 RF00002 38383785 0003735 0005840 9606 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacaugaucaucgacacuucgaacgcacuugcggccccgggcccggggcuacgccugucugagcgucgcu .........................................<<<<<<<<<....>>>>.....<.<<<......>>..........>>>..>...>>>....<<....>><<<<<<<<<>>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]]..........)))..)...)))....((....))((((((((())))))))).................... 60S ribosomal subunit bound to the E3-UFM1 complex - state 3 (native); 5.8S rRNA 8oi5 1 3171 2.9 RF02540,RF02541,RF02543 0003735 0005840 5476 ugaccucaaaucagguaggacuacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaacagggauugccucaguagcggcgagugaagcggcaaaagcucaaauuugaaaucuggcgucuuuggcguccgaguuguaauuugaagaagguaucuuugggcccggcucuugucuauguuccuuggaacaggacgucacagagggugagaaucccgugcgaugagaugacccgggucuguguaaaguuccuucgacgagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcuugagaucagacuugguauuuugcaugcgguuuaccgggccagcaucgguuuggagcggcaggauaauggcggaggaauguggcacggcuucugcuguguguuauagccucugacgauacugccagccuagaccgaggacugcgguuuaccuaggauguuggcauaaugaucuuaagucgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccguacgcguaaugaaagugaacgaaggugggggcccauuagggugcaccaucgaccgauccugauguguucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagaagucuugggguugaaaugaccuuaacuuauucucaaacuuuaaauauguaagaaguccuuguugcuuaauugaacguggacaauugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacgugaaguuaaagugccggaaugcacgcucaucagacaccacaaaagguguuaguucaucuagacagguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcgugcuacuuauacuucaccgugauugcuugacgcuuucacgaguaggcaggcguggaggucagugacgaagccuuugcuguaaagcugggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccaugucaacagcaguuggacauggguuagucgauccuaagagauggggaagcuccguuucaacgugcuugauuuuucaggccaaccaucgaaagggaauccgguuaaaauuccggaacuuggauauggauucuucacggcaacguaacugaauguggagacgucggcgugagcccugggaggaguuaucuuuucuucuuaacagcuuaucacccuggaauugguuuauccggagauggggucuuauggcuggaagagcgcgguaauuuugccgcguccggugcgcuuacgacgguccuugaaaauccacaggaaggaauaguuuucaugccaagucguacucauaaccgcagcaggucuccaagguuaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaaggaucgguuuaacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugugauggucagaaagugauguugacacaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaaaagacauggaggguguagaauaagugggagcuucggcgccggugaaauaccacuaccucuauaguuuuuuuacuuauucaaugaagcggagcuggaggucaaacuccacguucuagcauuaagcccucugggcgauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagguguccuaagggggacucauggagaacagaaaucuccaguagaacaaaaggguaaaaguccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaucgcaauaguaauugaacuuaguacgagaggaaccguucauucagauaauugguuuuugcggcugucugaucaggcaacgccgcgaagcuaccaucugcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcgaugauuuuugcccugcacauuuuagauggauacgaauaagacuuuuuagucgcuggaccauagcaggcuggcaacggugcgcuuagcggaaaggcuuugugcgcuugccggcggauagcaaugucaacaugcgcggggauaaauccuuugcauacgacuuagauguacaacggaguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagcucuuguugucugauuugu .......................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[...........<<.<<<<<<...>>>>>>.>>.............<<<<<...<<<<<<<<<<<<.<<<<<<<.....<<<<......>>>>.(.......<<<......)>>>....>>>>>>>....>>>>>>>>....>>>>..>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<<<<<.....<<<<..<<<<..>>>>..>>>>..<<<<<<<.<<<<<<<<.<<<<<<<....<<.<<<<<<<......<<<<<<......>>>>>>.......>>>>>>.>.>>.>>>>>.>>>>>>>>>>........<<<..>>>.....>>>>>>>....>>>>>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<..<<<<<.....>>>>>..>>>...<<....>>.......<<<<<..<<<<....>>>>...>>>>>.<<<<<<<<<..<<....>>>..>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<.........>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<...........................>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<..<<.....>>..>>>>>....>>>>>>..<<<<<<<<.<<......<<<<..<<<....>>>.>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<<<<<....>>>>>>......>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<...............>>>>><<.<<<<<<<<<<<......>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<..<<<.....<<<<....>>>>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<<...<.<<............................................>>.>...>>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>..............<<<<...>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<.................>>>>>..<<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.....<<<<<<.<<<.......<<..........<<<<....>>>>......>>.......<<<<<<...<<<<<<<..<<<......>>>..>>>>>>>.>>>>>>................>>>.>>>>>>..<<<<<<<.............>>....<<<<<<<<<.<<<....<<<<.<..<<<<<......>>>>>..>>>>>...>>>....>>>>.>>>>>..>>>>>.. .......................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........(((((...((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))).)..))))))))....))))..)))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((((((..(..((((..((((()))))..))))).((((((((((((((((.(((((((........((((((......((((((......)))))).......))))))......))))).))))))))))........(((..)))....))))))))....)))))))))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..((((....))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((....((.(((((((.....(((....(((..(.((((...((((.........)))).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(...............)...)))))))))))))..........]]].)....))))))))))...)))))))(((((..((.....))..)))))....))))))(.((((((((.((......((((..(((....))).))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........(.((.((......)).))).....))....))...(((((........)))))]]((((..(((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((......)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(..(((.....((((....)))).....))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((..(.(..(.(.................(......)...................)..))..)..)))))))....((((.....((((..(((((......)))))...........>..((((...))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).....((((((.(((.......((.(........((((....)))).....))).......((((((...(((((((..(((......)))..))))))).))))))................))).))))))..(((((((..(.......)..))..(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Crystal structure of the Candida albicans 80S ribosome in complex with Paromomycin (2mM); 25S 8oi5 3 121 2.9 RF00001 0003735 0005840 5476 gguugcggccauaucuagcagaaagcaccguuccccguucgaucaaccguaguuaagcugcuaagagcaauaccgaguaguguagugggagaccauacgcgaaacuauugugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<<............>>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of the Candida albicans 80S ribosome in complex with Paromomycin (2mM); 5S 8oi5 4 156 2.9 RF00002 0003735 0005840 5476 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaauaugaauugcagauauucgugaaucaucgaaucuuugaacgcacauugcgcccucugguauuccggagggcaugccuguuugagcgucgu .........................................<<<<<<.((.....>>>.....<.<<<<.....))............>>.>>..>...>>>....<<.....>><<<<<<<<<....>>>>>>>>>................... .........................................((((((.[[.....))).....(.((((.....]]............)).))..)...)))....((.....))(((((((((....)))))))))................... Crystal structure of the Candida albicans 80S ribosome in complex with Paromomycin (2mM); 5.8S 8oi5 B 1725 2.9 RF01960,RF02542,RF01959,RF00177 0003735 0005840 5476 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...<<<<<.{.((((>>>>><<<<.<<<<<<...<.<...<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<..<<..<<....<<<...........<<.....<..<<<.....>>>..>......>>........<<<<<..<<....>>..>>>>><...<<<<<<.........((((.<<<....>>>..............>>>>>>.....>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>....>.>.....<<<<<<<<.<<<<....>>>>.>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>>.........<<<[[.....<.<<...<<<.<<....<<<<<<<<<<......................>>>>>>>>>>.....<<<<.....>>>>....<<<<<.<<.......<<...<.......>..<<<....>>>....>>......>>.>>..>>>.........<<<..<<<<<<<<......)))).....>>>>>>>>>>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<..<<........>>.>>>>>>>>..>>>...<<..]]>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..)))).}<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<.....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<.<<<<<<<....>>>>>>>....>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>.....>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<......<<<.<<<<....>>>>.>>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<..<...<<....>>...>..>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>....... ....(((..[.[[[..))).((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((...........((.....(..(((.....)))..)......))........(((((..((....))..)))))(.(.(((((........[[.[[..(((....))).....(......)..))))).)...).(..(((..((((..).))).))).)...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(((((((.(.(((....))).).)))).)))......(.(.(...........))..).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....(((((.((((......((...).)........)))).))))).....(((.......)))....(((((.((.(.....((..((.......)).(((....)))....))..)...)).))..))).........(((..(((((.((.......]]..]]..)).)))))))).....))....((..((..(...((((...((.((((((.....((........))........)))))).))........((....))...))))..)..))...))...)))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((..(..........).))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.........(.(((........))).).......)))))...((.(((...(..((((.....(((.(((((....)))..(.((......)))...)).)))....(((((.((...(((..((((.(.(((((....))))).)....))))..)))..))..(.((((((.....))))))....)..))))).....)).))......).))))).....).)))))...)).)))).))).(...(((((((......((......(((.((((....)))).)))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..((((..(...((....))...)..))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>...... Crystal structure of the Candida albicans 80S ribosome in complex with Paromomycin (2mM); 18S 8oi5 AS 3065 2.9 RF02540,RF02541,RF02543 0003735 0005840 5476 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Crystal structure of the Candida albicans 80S ribosome in complex with Paromomycin (2mM); 25S 8oi5 AT 121 2.9 RF00001 0003735 0005840 5476 gguugcggccauaucuagcagaaagcaccguuccccguucgaucaaccguaguuaagcugcuaagagcaauaccgaguaguguagugggagaccauacgcgaaacuauugugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<<............>>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of the Candida albicans 80S ribosome in complex with Paromomycin (2mM); 5S 8oi5 AU 156 2.9 RF00002 0003735 0005840 5476 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaauaugaauugcagauauucgugaaucaucgaaucuuugaacgcacauugcgcccucugguauuccggagggcaugccuguuugagcgucgu .........................................<<<<<<.((.....>>>.....<.<<<<.....))............>>.>>..>...>>>....<<.....>><<<<<<<<<....>>>>>>>>>................... .........................................((((((.[[.....))).....(.((((.....]]............)).))..)...)))....((.....))(((((((((....)))))))))................... Crystal structure of the Candida albicans 80S ribosome in complex with Paromomycin (2mM); 5.8S 8oi5 CM 1778 2.9 RF01960,RF02542,RF01959,RF00177 0003735 0005840 5476 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....(((..[.[[[..))).((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((...............((.....(..(((.....)))..)......)).........((((..((....))..)))).(.(.(((((.........[.[[[.(((....))).....(......)..))))).)...).(..(((..((((..).))).))).)...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(((((((.(((.......).)).)))).)))....(.(.(.(...........))..)......)..((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((((((....(..(..().)....).......))))))))))......((((..................)))).....(((((.((.(.....((..((.......)).(((....)))....))..)...)).))..))).........(((..(((((.((......]]]...]..)).)))))))).....))....((..((..(...((((...(..((((((.(...((........))......).))))))..)........((....))...))))..)..))...))...)))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((..(..........).))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.........(.(((........))).).......)))))...((.(((...(..((((.....(((.(((((....)))..(.((......)))...)).)))....(((((.((...(((..((((((.(((((....))))).)..).))))..)))..))..(.((((((.....))))))....)..))))).....)).))......).))))).....).)))))...)).)))).))).(...(((((((......((......(((.((((....)))).)))....)).......)))))))......(....((((((..........))))))....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..((((..(...((((((..........................))))))...)..))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>...... Crystal structure of the Candida albicans 80S ribosome in complex with Paromomycin (2mM); 18S 8oin B8 1571 3.6 RF02541 URS000022E3AE_9823 37141370 0003735 0005840 9823 accaaagcuagcucaacauacuaaacaaauacaaaaauacaccaaaauaaaauaaaacauucaccuaacauuaaaguauaggagauagaaauuuuuauccugacgcuauagagauaguaccguaagggaaagaugaaagaauaaaauaaaaguaaaaaaaagcaaagauuaccccuucuaccuuuugcauaaugguuuaaccagaaaaaaucuaacaaagagaacuuuagcuagauaccccgaaaccagacgagcuacccaugagcaguuuaaaagaaccaacucaucuauguggcaaaauagugagaagacuuguagguagaggugaaaagccuaacgagccuggugauagcugguuguccgagaaagaauuuuaguucaaccuuaaaaauaccccaaaaacccuaaauuccaauguauuuuuaagagauagucuaaaaagguacagcuuuuuagaaacggauacaaccuugacuagagaguaaaaucuuaauacuaccauaguaggccuaaaagcagccaucaauugagaaagcguuaaagcucaacaaauucaccaacauaaucccaaaaacuaauaacaaacuccuagcccaauaccggacuaaucuauugaaacauagaagcaauaauguuaauaugaguaacaagaagccuuucuccucgcacacgcuuacaucaguaacuaauaauauacugauaauuaacaaccaauaaaccaaaacaacacuaaaacguuuauuaauuacauuguuaacccaacacaggagugcaccaaggaaagauuaaaagaaguaaaaggaacucggcaaacacaaaccccgccuguuuaccaaaaacaucaccucuagcauuacuaguauuagaggcaaugccugcccagugacaccaguuuaacggccgcgguauucugaccgugcaaagguagcauaaucacuuguucuccaanuaaggacuuguaugaauggccacacgaggguuuuacugucucuuacuuccaaucagugaaauuaaccuucccgugaagaggcgggaauaaaaaaauaagacgagaagacccuauggagcuuuaauuaacuauuccaaaaguuaaacaacucaaccacaaagggauaaaacauaacuuaacauggacuagcaauuucgguugnggugaccucggaguacaaaaaacccuccgagugauuuuaaucuagacaaaccagucaaaauaaccauaacaucacuuauugauccaaaauuuugaucaacggaacaaguuacccuagggauaacagcgcaauccuguucuagaguuccuaucgacaauaggguuuacgaccucgauguuggaucaggacacccaaauggugcaaccgcuauuaaagguucguunnuucaacgauuaaaguccuacgugaucugaguucagaccggagcaauccaggucgguuucuaucuauuauaaauuucucccaguacgaaaggacaagagaaaugggaccaaccucacaaacgcgucucagagauaauuaaugauuuaaucuuaaccuaauuaacucauaauaaauccagcccuagaacagggcaca <<.<......<<<<.......................................<......>.................<<.....>>..............>>.>>.............<<....>>...................>....>>...........<<<.......>>>...<.<........>.>..<<<<<........<<<<<.<..<<....>>...>.>>>>>..<<.<..<<<<<.<.....<<<.<<<<<..<<<......>>>...<<<..<<<<........>>>>.>>>....>>>>>.>>>...<<<.....>>>......>.>>>>...>..>.>>..<<<<<.....<<<<....>>>>..<<<<<<<<<<<<.....<<........>>.....>>>>>>>>>>>.>....<<<<<<<<<......>>>>>>>>>...<<......>>....<<<<.<<<...................<....<<<.........>>>....>.......<<<......>>>........................................>>>>>>>........>>>>>...<<<<<......>>>>>.........>>>>>.<......<<..<<<....>>><<<..<<<<........<<<<<....<<....>>..>>>>>......<<<..<<<<<<<.................>>>>>>>.......>>>.....<<......>>.>>>>.....>>>..<<<<....<<<<<<<.<<.........<.....<<<<<<<<..<<<.........>>>...<<<<<<.............>>>>>>...<<<<.<<<..<<<<<....>>>..>>>>><<<<<<......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>.>..>>.>>>>>>...>..>>.>>>>>>>.>>>>.>>.....>.....<<<<<........>>>>>.......<<<.<<<.<<......<<<<.<<<<<<..<<<<..<<<.<<<<.<<<<<<............................>>>>>>....>>>>.>>>.>>>>..<<<<.....>>>><<<<<<...........>>>>>>.<<<<....<<...<<<......>>>...>>.........>>>>..........<<<....>>>............>>>>..>>>>>>.......<<<..<.<<<<<<...<<.......>>...>>>>>>...>.>>.>.......<.<<<.<<<<<<..<<.<<<<<<......>>>>>>...>>.<<<<<.....>>>>>.....>>>>>..>...>>>..>....<<<<<<<....>>>.>>>>....>>..>>>>>>.<<.<<<<<<<.................>>>>>>><<<<<...<.........>.>>>>>.<<<...<<<<.<............>..>>>>...>>>.>>.........<<<<.......>>>>... ((.(...(..((((.......................................(...[..)........(..(.....((.]...))....)..)......)).)).............((....))....)..............)....))...........(((.......))).{.(.(........).)..(((((........(((((.(..((....))...).)))))..((.(...((((.(.....(((.((((((.((......[.))...(((..((((........)))).)))..).))))).))).(.(((.....)))...)..).))))......).))..(((((.....((((....))))...((((((((.((.....((........)).....)).))))))))......(((((((((......)))))))))...((......))....((((.(((...................(.(..(((.........)))..).)....(..(((......)))).......................................)))))))........)))))...(((((......))))).........))))).(......((..(((....)))(((..((((......(.(((((....((....))..)))))......(((..(((((((...........(..)..))))))).......))).)...((......)).)))).....)))..((((....(((((((.((..(....(.......((.(((((.].((.........))....((((((.............))))))....(((.(((..((.((....))...)))))(((((........)))))........((..........(((((.......)))))..)..)....)))....)).))).))..)..))).))))))).)))).)).....)..[..(((((.....}].))))).......(((.(((.((......((((.((((((..(((...(((.((((.((((((............................))))))....)))).)))..)))..(((......[)))((((((..........]))))))((((((..)((.(.(((...[..))))..)).........))))..........(((....))).....)].....))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(..(.((((((..((.((((((......))))))...)).(((((.....))))).....)))))..)...)...).....(((((((....))).))))....))..)))))).((.(((((((......(....).....)))))))(((((...(.(.....).).))))).(((....((...................))....))).)).........((((.......))))... 55S mammalian mitochondrial ribosome with mtRF1 and P-site tRNA; 16S rRNA 8oin AA 960 3.6 RF00177,RF02542 URS000268142B_9823 37141370 0003735 0005840 9823 acagguuugguccuggccuuucuauuaauucuuaauaaaauuacacaugcaaguauccgcgccccggugagaaugcccuccagaucuuaaagaucaaaaggagcagguaucaagcacaccuauaacgguagcucauaacgccuugcucaaccacacccccacgggaaacagcagugauaaaaauuaagccaugaacgaaaguuugacuaaguuauauuaauuagaguugguaaaucucgugccagccaccgcggucauacgauuaacccaaauuaauagauccacggcguaaagaguguuuaagaaaaaaaaucacaauagaguuaaauuauaacuaagcuguaaaaagcccuaguuaaaauaaaauaacccacgaaagugacucuaauaauccugacacacgauagcuaggacccaaacuggganuagauaccccacuaugccuagcccuaaacccaaauaguuacauaacaaaacuauucgccagaguacuacucgcaacugccuaaaacucaaaggacuuggcggugcuucacauccaccuagaggagccuguucuauaaucgauaaaccccgauagaccuuaccaacccuugccaauucagccuauauaccgccaucuucagcaaacccuaaaaaggaacaauaguaagcacaaucauagcacauaaaaacguuaggucaagguguagcuuauggguuggaaagaaaugggcuacauuuucuacauaagaauauccaccacacgaaaguuuuuaugaaacuaaaaaccaaaggaggauuuagcaguaaaucaagaauagagugcuugauugaauaaggccaugaagcacgcacacaccgncngucacccuccucaagcauguaguaauaaaaauaaccuauauucaauuacacaaccaugcaagaagagacaagucguaacaagguaagcauacuggnnagugugcuuggauuacc ..((((..<<<<<<.)))).<<<<<<<<<..<<<<<<<...<.<<<.<<<..<<....>>......<<......<<<<<...<<<<<...>>>>>...>>>.>>.<<<....<<...<<<......>>>..>>......>>>..<.....>.>>.<<<....>>>.....>>>>>>>.........<<....<<<<....>>>>..>>....>.>>>>>>...<.<<<<<<.....(((.....((.>>>)).......)))..>>>.>..>>>>>>>>>.....<<<((.....<<<<...<<..............<<<<<<.....<.<<<<<<.<<<......>>>..>>>>>>..>..........<<<....>>>>>>>>>......>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<<.....))..>>>>>>>.>>>.<<<........<<....>>......>>>..>>>>>><<<<<.<<<<<<<...<<..<<<<<..<<<<<<<<<<.....<<........>>..........<<<<<<<..........<<<.<<<..<<<<<<.......<<..<<<<<....>>>.......>>..>>......<<.....>>..........>>>...>>>>>>>>>...>>>>>>>..>>.>>>>>>>>.....<<<<.....>>>>................<<<<<<<......>>>>>>>..........>>>>>.....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<...<<<.<<..<<<<<..<<<<<...<<<<.....>>>>..>>>>>.....>>>>>..>>.>>>....>.>>...>.....<<<<<<<<<....>>>>>>>>>........ [.[[[[..(((((..]]]]](((((((((..((((((((..(.(((.(((..((....))......(((.....(((((...(((((...)))))...))).)).(((....((..((((......))).)))......)))..(.....)))).(((....))).....)))))))......(..((...(((((....)))).))).).)).))))))...(.((([[[.....(((.....((.]]])).......)))..))).)..))))))))).....((([[...(.((((...((..............(((((((......((((((.((........))..))))))......).......((....)).))))))......))...))))....((((((...((...((((.........))))...))))))))......{...(((((((.....]]..))))))))))).(((........((....))......)))...)))))(((((.(((((((...((..(((((..((((((((((.....((........))..........(((((((..(......).((.(((...((((((.(....((..(((((....))).......))..))......((.....))......).).)))...)).)))))....)))))))..)).)))))))).(...((((.....))))...........(....(((((((......)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(...(((.((..(((((..(((((...(((.......)))..))))).....)))))..)).)))....).))...)..)..(((((((((....)))))))))}....... 55S mammalian mitochondrial ribosome with mtRF1 and P-site tRNA; 12S rRNA 8oin AG 71 3.6 URS0000D77905_9606 37141370 9606 aguaaggucagcuaaauaagcuaucgggcccauaccccgaaaauguugguuauacccuucccguacuacca <<<<.<<..<<<<.....>>>>.<<<<<.......>>>>>.......<<......>>...>>.>>>>.... ((((.((..((((.....)))).(((((.......)))))....(..((......))..))).)))).... 55S mammalian mitochondrial ribosome with mtRF1 and P-site tRNA; P-site Met-tRNA(fMet) 8oip AA 960 3.6 RF00177,RF02542 URS00000CFF65_9823 37141370 0003735 0005840 9823 acagguuugguccuggccuuucuauuaauucuuaauaaaauuacacaugcaaguauccgcgccccggugagaaugcccuccagaucuuaaagaucaaaaggagcagguaucaagcacaccuauaacgguagcucauaacgccuugcucaaccacacccccacgggaaacagcagugauaaaaauuaagccaugaacgaaaguuugacuaaguuauauuaauuagaguugguaaaucucgugccagccaccgcggucauacgauuaacccaaauuaauagauccacggcguaaagaguguuuaagaaaaaaaaucacaauagaguuaaauuauaacuaagcuguaaaaagcccuaguuaaaauaaaauaacccacgaaagugacucuaauaauccugacacacgauagcuaggacccaaacuggganuagauaccccacuaugccuagcccuaaacccaaauaguuacauaacaaaacuauucgccagaguacuacucgcaacugccuaaaacucaaaggacuuggcggugcuucacauccaccuagaggagccuguucuauaaucgauaaaccccgauagaccuuaccaacccuugccaauucagccuauauaccgccaucuucagcaaacccuaaaaaggaacaauaguaagcacaaucauagcacauaaaaacguuaggucaagguguagcuuauggguuggaaagaaaugggcuacauuuucuacauaagaauauccaccacacgaaaguuuuuaugaaacuaaaaaccaaaggaggauuuagcaguaaaucaagaauagagugcuugauugaauaaggccaugaagcacgcacacaccgncngucacccuccucaagcauguaguaauaaaaauaaccuauauucaauuacacaaccaugcaagaagagacaagucguaacaagguaagcauacuggnnagugugcuuggauuacc ..((((..<<<<<<.)))).<<<<<<<<<..<<<<<<<...<.<<<.<<<..<<....>>......<<......<<<<<...<<<<<...>>>>>...>>>.>>.<<<....<<...<<<......>>>..>>......>>>..<.....>.>>.<<<....>>>.....>>>>>>>.........<<....<<<<....>>>>..>>....>.>>>>>>...<.<<<<<<.....(((.....((.>>>)).......)))..>>>.>..>>>>>>>>>.....<<<((.....<<<<...<<..............<<<<<<.....<.<<<<<<.<<<......>>>..>>>>>>..>..........<<<....>>>>>>>>>......>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<<.....))..>>>>>>>.>>>.<<<........<<....>>......>>>..>>>>>><<<<<.<<<<<<<...<<..<<<<<..<<<<<<<<<<.....<<........>>..........<<<<<<<..........<<<.<<<..<<<<<<.......<<..<<<<<....>>>.......>>..>>......<<.....>>..........>>>...>>>>>>>>>...>>>>>>>..>>.>>>>>>>>.....<<<<.....>>>>................<<<<<<<......>>>>>>>..........>>>>>.....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<...<<<.<<..<<<<<..<<<<<...<<<<.....>>>>..>>>>>.....>>>>>..>>.>>>....>.>>...>.....<<<<<<<<<....>>>>>>>>>........ [.[[[[..(((((..]]]]](((((((((..((((((((..(.(((.(((..((....))......(((.....(((((...(((((...)))))...))).)).(((....((..((((......))).)))......)))..(.....)))).(((....))).....)))))))......(..((...(((((....)))).))).).)).))))))...(.((([[[.....(((.....((.]]])).......)))..))).)..))))))))).....((([[...(.((((...((..............(((((((......((((((.((........))..))))))......).....(.((....)))))))))......))...))))....((((((...((...((((.........))))...))))))))......{...(((((((.....]]..))))))))))).(((........((....))......)))...)))))(((((.(((((((...((..(((((..((((((((((.....((........))..........(((((((..(......).((.(((...((.(((.(....((..(((((....))).......))..))......((.....))......).).))....)).)))))....)))))))..)).)))))))).(...((((.....))))...........(....(((((((......)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(...(((.((..(((((..(((((...(((.......)))..))))).....)))))..)).)))....).))...)..)..(((((((((....)))))))))}....... 28S mammalian mitochondrial small ribosomal subunit with mtRF1 and P-site tRNA; 12S rRNA 8oip AG 72 3.6 URS000268140A_9606 37141370 9606 aguaaggucagcuaaauaagcuaucgggcccauaccccgaaaauguugguuauacccuucccguacuaccaM <<<<.<<..<<<<.....>>>>.<<<<<.......>>>>>.......<<......>>...>>.>>>>..... ((((.((..((((.....)))).(((((.......)))))....(..((......))..))).)))).... 28S mammalian mitochondrial small ribosomal subunit with mtRF1 and P-site tRNA; P-site Met-tRNA(fMet) 8oiq B8 1571 3.5 RF02541 URS000022E3AE_9823 37141370 0003735 0005840 9823 accaaagcuagcucaacauacuaaacaaauacaaaaauacaccaaaauaaaauaaaacauucaccuaacauuaaaguauaggagauagaaauuuuuauccugacgcuauagagauaguaccguaagggaaagaugaaagaauaaaauaaaaguaaaaaaaagcaaagauuaccccuucuaccuuuugcauaaugguuuaaccagaaaaaaucuaacaaagagaacuuuagcuagauaccccgaaaccagacgagcuacccaugagcaguuuaaaagaaccaacucaucuauguggcaaaauagugagaagacuuguagguagaggugaaaagccuaacgagccuggugauagcugguuguccgagaaagaauuuuaguucaaccuuaaaaauaccccaaaaacccuaaauuccaauguauuuuuaagagauagucuaaaaagguacagcuuuuuagaaacggauacaaccuugacuagagaguaaaaucuuaauacuaccauaguaggccuaaaagcagccaucaauugagaaagcguuaaagcucaacaaauucaccaacauaaucccaaaaacuaauaacaaacuccuagcccaauaccggacuaaucuauugaaacauagaagcaauaauguuaauaugaguaacaagaagccuuucuccucgcacacgcuuacaucaguaacuaauaauauacugauaauuaacaaccaauaaaccaaaacaacacuaaaacguuuauuaauuacauuguuaacccaacacaggagugcaccaaggaaagauuaaaagaaguaaaaggaacucggcaaacacaaaccccgccuguuuaccaaaaacaucaccucuagcauuacuaguauuagaggcaaugccugcccagugacaccaguuuaacggccgcgguauucugaccgugcaaagguagcauaaucacuuguucuccaanuaaggacuuguaugaauggccacacgaggguuuuacugucucuuacuuccaaucagugaaauuaaccuucccgugaagaggcgggaauaaaaaaauaagacgagaagacccuauggagcuuuaauuaacuauuccaaaaguuaaacaacucaaccacaaagggauaaaacauaacuuaacauggacuagcaauuucgguugnggugaccucggaguacaaaaaacccuccgagugauuuuaaucuagacaaaccagucaaaauaaccauaacaucacuuauugauccaaaauuuugaucaacggaacaaguuacccuagggauaacagcgcaauccuguucuagaguuccuaucgacaauaggguuuacgaccucgauguuggaucaggacacccaaauggugcaaccgcuauuaaagguucguunnuucaacgauuaaaguccuacgugaucugaguucagaccggagcaauccaggucgguuucuaucuauuauaaauuucucccaguacgaaaggacaagagaaaugggaccaaccucacaaacgcgucucagagauaauuaaugauuuaaucuuaaccuaauuaacucauaauaaauccagcccuagaacagggcaca <<.<......<<<<.......................................<......>.................<<.....>>..............>>.>>.............<<....>>...................>....>>...........<<<.......>>>...<.<........>.>..<<<<<........<<<<<.<..<<....>>...>.>>>>>..<<.<..<<<<<.<.....<<<.<<<<<..<<<......>>>...<<<..<<<<........>>>>.>>>....>>>>>.>>>...<<<.....>>>......>.>>>>...>..>.>>..<<<<<.....<<<<....>>>>..<<<<<<<<<<<<.....<<........>>.....>>>>>>>>>>>.>....<<<<<<<<<......>>>>>>>>>...<<......>>....<<<<.<<<........................<<<.........>>>............<<<......>>>........................................>>>>>>>........>>>>>...<<<<<......>>>>>.........>>>>>.<......<<..<<<....>>><<<<.<<<<........<<<<<....<<....>>..>>>>>......<<<..<<<<<<<.................>>>>>>>.......>>>.....<<......>>.>>>>....>>>>..<<<<....<<<<<<<.<<.........<.....<<<<<<<<..<<<.........>>>...<<<<<<.............>>>>>>...<<<<.<<<..<<<<<....>>>..>>>>><<<<<<......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>.>..>>.>>>>>>...>..>>.>>>>>>>.>>>>.>>.....>.....<<<<<........>>>>>.......<<<.<<<.<<......<<<<.<<<<<<..<<<<..<<<.<<<<.<<<<<<............................>>>>>>....>>>>.>>>.>>>>..<<<<.....>>>><<<<<<...........>>>>>>.<<<<....<<...<<<......>>>...>>.........>>>>..........<<<....>>>............>>>>..>>>>>>.......<<<..<.<<<<<<...<<.......>>...>>>>>>...>.>>.>.......<<<<<.<<<<<<..<<.<<<<<<......>>>>>>...>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>>>>.<<.<<<<<<<.................>>>>>>><<<<<...<.........>.>>>>>.<<<...<<<<.<............>..>>>>...>>>.>>.........<<<<.......>>>>... ((.(...(..((((.......................................(...[..)........(..(.....((.]...))....)..)......)).)).............((....))....)..............)....))...........(((.......))).[.(.(........).)..(((((........(((((.(..((....))...).)))))..((.(...((((.(.....(((.((((((.((......[.))...(((..((((.......{)))).)))..).))))).))).(.(((.....)))...)..).))))......).))..(((((.....((((....))))...(((((((((((.....((........)).....)))))))))))......(((((((((......)))))))))...((......))....((((.(((...................(.(..(((.........)))..).)....(..(((......)))).......................................)))))))........)))))...(((((......))))).........))))).(......((..(((....)))(((..((((......(.(((((....((....))..)))))......(((..(((((((.................))))))).......))).)...((......)).)))).....)))..((((....(((((((.((..(....(.......((.(((((.].((.........))....((((((.............))))))....(((.(((..((.((....))...)))))(((((........)))))........((..........(((((.......)))))..)..)....)))....)).))).))..)..))).))))))).)))).)).....)..{..(((((.....]}.))))).......(((.(((.((......((((.((((((..((((..(((.((((.((((((............................))))))....)))).))).))))..(((......[)))((((((..........]))))))((((((..)((.(.(((...[..))))..)).........))))..........(((....))).....)].....))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(..(.((((((..((.((((((......))))))...)).(((((.....))))).....)))))..)...)...).....(((((((....))).))))..}.))..)))))).((.(((((((......(....).....)))))))(((((...(.(.....).).))))).(((....((...................))....))).)).........((((.......))))... 39S mammalian mitochondrial large ribosomal subunit with mtRF1 and P-site tRNA; 16S rRNA 8oiq AG 71 3.5 URS0000D77905_9606 37141370 9606 aguaaggucagcuaaauaagcuaucgggcccauaccccgaaaauguugguuauacccuucccguacuacca <<<<.<<..<<<<.....>>>>.<<<<<.......>>>>>.......<<......>>...>>.>>>>.... ((((.((..((((.....)))).(((((.......)))))....(..((......))..))).)))).... 39S mammalian mitochondrial large ribosomal subunit with mtRF1 and P-site tRNA; P-site Met-tRNA(fMet) 8oir B8 1558 3.1 RF02541 URS00021ED93A_9606 37141370 0003735 0005840 9606 gcuaaaccuagccccaaacccacuccaccuuacuaccagacaaccuuagccaaaccauuuacccaaauaaaguauaggcgauagaaauugaaaccuggcgcaauagauauaguaccgcaagggaaagaugaaaaauuauaaccaagcauaauauagcaaggacuaaccccuauaccuucugcauaaugaauuaacuagaaauaacuuugcaaggagagccaaagcuaagacccccgaaaccagacgagcuaccuaagaacagcuaaaagagcacacccgucuauguagcaaaauagugggaagauuuauagguagaggcgacaaaccuaccgagccuggugauagcugguuguccaagauagaaucuuaguucaacuuuaaauuugcccacagaacccucuaaauccccuuguaaauuuaacuguuaguccaaagaggaacagcucuuuggacacuaggaaaaaaccuuguagagagaguaaaaaauuuaacacccauaguaggccuaaaagcagccaccaauuaagaaagcguucaagcucaacacccacuaccuaaaaaaucccaaacauauaacugaacuccucacacccaauuggaccaaucuaucacccuauagaagaacuaauguuaguauaaguaacaugaaaacauucuccuccgcauaagccugcgucagauuaaaacgaacugacaauuaacagcccaauaucuacaaucaaccaacaagucauuauuacccucacugucaacccaacacaggcaugcucauaaggaaagguuaaaaaaaguaaaaggaacucggcaaaucuuaccccgccuguuuaccaaaaacaucaccucuagcaucaccaguauuagaggcaccgccugcccagugacacauguuuaacggccgcgguacccuaaccgugcaaagguagcauaaucacuuguuccuuaanuagggaccuguaugaauggcuccacgaggguucagcugucucuuacuuuuaaccagugaaauugaccugcccgugaagaggcgggcauaacacagcaagacgagaagacccuauggagcuuuaauuuauuaaugcaaacaguaccuaacaaacccacagguccuaaacuaccaaaccugcauuaaaaauuucgguugnggcgaccucggagcagaacccaaccuccgagcaguacaugcuaagacuucaccagucaaagcgaacuacuauacucaauugauccaauaacuugaccaacggaacaaguuacccuagggauaacagcgcaauccuauucuagaguccauaucaacaauaggguuuacgaccucgauguuggaucaggacaucccgauggugcagccgcuauuaaagguucguunnuucaacgauuaaaguccuacgugaucugaguucagaccggaguaauccaggucgguuucuaucuacuuucaaauuccucccuguacgaaaggacaagagaaauaaggccuacuucacaaagcgccuucccccguaaaugauaucaucucaacuuaguauuauacccacacccacccaagaacaggguuugu <<<.......<<<<.....................................<......>...............<<.....>>.............>>.>>.............<<....>>......................>>>...........<<<.......>>>...<.<........>.>.<<<<<<.........<<<.<<..<<....>>...>>.>>>...<<.<..<<<<<.<.....<<<<<.<<<..<<<.....>>>...<<<..<<<<........>>>>.>>>....>>>.>>>>>...<<.......>>......>.>>>>...>..>.>>..<<<<<<....<<<<....>>>><<<.<<<<<<<<<<.....<<..........>>.....>>>>>>>>>>..>>>.<<<<<<<<<<......>>>>>>>>>>...<<<......>>>....<<<.<<<...<..............<....<<<.........>>>....>.......<<<......>>>....................................>...>>>>>>........>>>>>>...<<<<<......>>>>>.........>>>>>><......<<..<<<....>>><<<<..<<<<........<<<<<..<.....>..>>>>>......<<<...<<<<.......................>>>>.......>>>.....<<......>>.>>>>.....>>>>..<<<<...<<<<<<<<.<<.........<......<<<<<<..<<<.........>>>...<<<<<<.............>>>>>>....<<<.<<<..<<<<<....>>>..>>>>><<<<<<......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>....>>.>>>>.....>..>>.>>>>>>>>>>>>.>>.....>.....<<<<<........>>>>>.......<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<....<<<........<<<....>>>.......>>>......>>>>>>>>>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<.....<<<..<<<<.....>>>>..>>>...........>>.........<<<....>>>............>>>>..>>>>>>.......<<<..<.<<<<<<...<<.......>>...>>>>>>...>.>>.>.......<.<<<.<<<<<<..<<.<<<<<<......>>>>>>...>>.<<<<<.....>>>>>.....>>>>>..>...>>>..>....<<<<<<<....>>>.>>>>....>>..>>>.>>.....<<<.<<<.................>>>.>>><<<<<...<<<....>>>.>>>>>......<<<................>>>.................<<<<.......>>>>.... ((.....(..((((.....................................(...[..).........(.....((.]...))....)........)).)).............((....))....)..................)).........(.(((.......))).[.(.(........).).((((((.........(((.((..((....))...)).)))...((.(...((((.(.....(((((.((((.(((....[)))...(((..((((.......{)))).)))..).))).))))).(.((.......))...)..).))))......).))..((((((....((((....)))).((.((((((((((.....((..........)).....))))))))))..))..((((((((((......))))))))))...(((......)))....(((.(((...(..............(.(..(((.........)))..).)....(..(((......))))...................................)...))))))........))))))...(((((......))))).........))))))(......((..(((....)))(((...((((......(.(((((.((.....)).)))))......(((...((((...............(..)....)))).......))).)...((......)).))))......)))..((((....(((((((.((..(....(........((((((.].((.........))....((((((.............))))))....(((.(((..(((((....)))..)))))(((((........)))))........((..........(((((.......)))))..)..)....)))....)).))))....)..))).))))))).)))).)).....)).{..(((((.....]}.))))).......((..(((.((......((((.((((((..(((((.((((((((....(((........(((....))).......)))......)))))))))))))..(((......[)))((((((..........]))))))(.((.....((...(((....[..)))...))...........)).........(((....))).....)].....))))..))))))......((((..(.((((((.(.((.......)))..))))))...).)).).)......(.((.((((((..((.((((((......))))))...)).(((((.....))))).....)))))..)...))..).....(((((((....))).))))..}.))..))).))...(.(((.(((......(....).....))).)))(((((...(((....))).)))))......(((................)))......).........(((((.......))))..). 55S human mitochondrial ribosome with mtRF1 and P-site tRNA; 16S rRNA 8oir AA 955 3.1 RF00177 URS0001A24B4C_9606 37141370 0003735 0005840 9606 aauagguuugguccuagccuuucuauuagcucuuaguaagauuacacaugcaagcauccccguuccagugaguucacccucuaaaucaccacgaucaaaagggacaagcaucaagcacgcagcaaugcagcucaaaacgcuuagccuagccacacccccacgggaaacagcagugauuaaccuuuagcaauaaacgaaaguuuaacuaagcuauacuaaccccaggguuggucaauuucgugccagccaccgcggucacacgauuaacccaagucaauagaagccggcguaaagaguguuuuagaucacccccuccccaauaaagcuaaaacucaccugaguuguaaaaaacuccaguugacacaaaauagacuacgaaaguggcuuuaacauaucugaacacacaauagcuaagacccaaacuggganuagauaccccacuaugcuuagcccuaaaccucaacaguuaaaucaacaaaacugcucgccagaacacuacgagccacagcuuaaaacucaaaggaccuggcggugcuucauaucccucuagaggagccuguucuguaaucgauaaaccccgaucaaccucaccaccucuugcucagccuauauaccgccaucuucagcaaacccugaugaaggcuacaaaguaagcgcaaguacccacguaaagacguuaggucaagguguagcccaugagguggcaagaaaugggcuacauuuucuaccccagaaaacuacgauagcccuuaugaaacuuaagggucgaagguggauuuagcaguaaacugagaguagagugcuuaguugaacagggcccugaagcgcguacacaccgncngucacccuccucaaguauacuucaaaggacauuuaacuaaaaccccuacgcauuuauauagaggagacaagucguaacaugguaaguguacuggnnagugcacuuggacgaacc ...((((..<<<<<<.)))).<<<<<<.<<..<<<<<<<<..<.<<<.<<<..<......>......<<.......<<<<....<<.......>>....>>>>..<<<<....<<...<<<....>>>..>>......>>>>.<<...>>.>>.<<<....>>>.....>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>.....<<<<<<<<.....(((.....((.>>>)).......)))..>>>>>..>>.>>>>>>....<<<((.....<<<<..<<<<...............<<<<<<......<<<.<<<.<<<......>>>..>>>.>>>.............<<....>>.>>>>>>.....>>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<.<<<<.......))...>>>>.>.>>>.<<.......<<<<....>>>>.....>>..>>>>>><<<<<.<<<<<<<...<<<.<<<<<..<<<<<<<<<<.....<<........>>..........<<<<<<<.......<<.<<<..<<<<<<.......<<..<<<<<.....>>>.......>>..>>.....<<<....>>>.........>>>...>>>>>>>>....>>>>>>>..>>.>>>>>>>>.....<<<<.....>>>>.....<<...<<<<<<<.......>>>>>>>>...>.....>>>>>.....<<<<<<<.........>>>>>>>.....>>>...>>>>>>>>>>.>>....<..<<.<...<<<<<<..<<<<<......<<<...<<<.....>>>..>>>.......>>>>>.>>>>>>....>.>>...>.....<<<<<<<<<....>>>>>>>>>......... .[.[[[[..(((((..]]]]]((((((.((..((((((((..(.(((.(((..(......)......(((......((((.(..(((.....))).)..))))..((((....((..((((....))).)))......)))).((...))))).(((....))).....)))))))......(.(((...(((((....)))).))))).)).)))))).....((((([[[.....(((.....((.]]])).......)))..)))))..)).))))))....((([[...(.((((...(((...............(((((((.....(((.(((.((........))..))).))).....).....(.((....))))))))).....)))....))))....((((((...((...((((.........))))...))))))))......{...(.(((((......]]..))))).))))).((.......((((....)))).....))...)))))(((((.(((((((...(((.(((((..((((((((((.....((........))..........(((((((.......((.(((...((((((.(....((..(((((.....))).......))..)).....(((....))).....).).)))...)).)))))....)))))))..)).)))))))).(...((((.....)))).....(....(((((((.......)))))))....)..)..))))).....(((((((.........))))))).....)))...)))))))))).))..(.(..((.(...((((((...((((..((..(((....((.....))...)))..).)..))))..))))))....).))...)..)..(((((((((....)))))))))}........ 55S human mitochondrial ribosome with mtRF1 and P-site tRNA; 12S rRNA 8oir AG 71 3.1 URS0000D77905_9606 37141370 9606 aguaaggucagcuaaauaagcuaucgggccnauaccccgaaaauguugguuauacccuucccguacuacca <<<<.<<..<<<<.....>>>>.<<<<<.......>>>>>....<..<<......>>..>>>.>>>>.... ((((.((..((((.....))))..((((.......)))).....(..((......))..))).)))).... 55S human mitochondrial ribosome with mtRF1 and P-site tRNA; P-site Met-tRNA(Met) 8oir AI 33 3.1 37141370 9606 nnnnaugaggnnnnnnnnnnnnnnnnnnnnnnn ................................. ................................. 55S human mitochondrial ribosome with mtRF1 and P-site tRNA; mRNA 8ois AA 955 3.0 RF00177 URS0001A24B4C_9606 37141370 0003735 0005840 9606 aauagguuugguccuagccuuucuauuagcucuuaguaagauuacacaugcaagcauccccguuccagugaguucacccucuaaaucaccacgaucaaaagggacaagcaucaagcacgcagcaaugcagcucaaaacgcuuagccuagccacacccccacgggaaacagcagugauuaaccuuuagcaauaaacgaaaguuuaacuaagcuauacuaaccccaggguuggucaauuucgugccagccaccgcggucacacgauuaacccaagucaauagaagccggcguaaagaguguuuuagaucacccccuccccaauaaagcuaaaacucaccugaguuguaaaaaacuccaguugacacaaaauagacuacgaaaguggcuuuaacauaucugaacacacaauagcuaagacccaaacuggganuagauaccccacuaugcuuagcccuaaaccucaacaguuaaaucaacaaaacugcucgccagaacacuacgagccacagcuuaaaacucaaaggaccuggcggugcuucauaucccucuagaggagccuguucuguaaucgauaaaccccgaucaaccucaccaccucuugcucagccuauauaccgccaucuucagcaaacccugaugaaggcuacaaaguaagcgcaaguacccacguaaagacguuaggucaagguguagcccaugagguggcaagaaaugggcuacauuuucuaccccagaaaacuacgauagcccuuaugaaacuuaagggucgaagguggauuuagcaguaaacugagaguagagugcuuaguugaacagggcccugaagcgcguacacaccgncngucacccuccucaaguauacuucaaaggacauuuaacuaaaaccccuacgcauuuauauagaggagacaagucguaacaugguaaguguacuggnnagugcacuuggacgaacc ...((((..<<<<<<.)))).<<<<<<.<<..<<<<<<<<..<.<<<.<<<..<......>......<<.......<<<<....<<.......>>....>>>>..<<<<....<<...<<<....>>>..>>......>>>>.<<...>>.>>.<<<....>>>.....>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>.....<<<<<<<<.....(((.....((.>>>)).......)))..>>>>>..>>.>>>>>>....<<<((.....<<<<..<<<<...............<<<<<<......<<<.<<<.<<<......>>>..>>>.>>>.............<<....>>.>>>>>>.....>>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<.<<<<.......))...>>>>.>.>>>.<<.......<<<<....>>>>.....>>..>>>>>><<<<<.<<<<<<<...<<<.<<<<<..<<<<<<<<<<.....<<........>>..........<<<<<<<.......<<.<<<..<<<<<<.......<<..<<<<<.....>>>.......>>..>>.....<<<....>>>.........>>>...>>>>>>>>....>>>>>>>..>>.>>>>>>>>.....<<<<.....>>>>.....<<...<<<<<<<.......>>>>>>>>...>.....>>>>>.....<<<<<<<.........>>>>>>>.....>>>...>>>>>>>>>>.>>....<..<<.<...<<<<<<..<<<<<......<<<...<<<.....>>>..>>>.......>>>>>.>>>>>>....>.>>...>.....<<<<<<<<<....>>>>>>>>>......... .[.[[[[..(((((..]]]]]((((((.((..((((((((..(.(((.(((..(......)......(((......((((.(..(((.....))).)..))))..((((....((..((((....))).)))......)))).((...))))).(((....))).....)))))))......(.(((...(((((....)))).))))).)).)))))).....((((([[[.....(((.....((.]]])).......)))..)))))..)).))))))....((([[...(.((((...(((...............(((((((.....(((.(((.((........))..))).))).....).....(.((....))))))))).....)))....))))....((((((...((...((((.........))))...))))))))......{...(.(((((......]]..))))).))))).((.......((((....)))).....))...)))))(((((.(((((((...(((.(((((..((((((((((.....((........))..........(((((((.......((.(((...((((((.(....((..(((((.....))).......))..)).....(((....))).....).).)))...)).)))))....)))))))..)).)))))))).(...((((.....)))).....(....(((((((.......)))))))....)..)..))))).....(((((((.........))))))).....)))...)))))))))).))..(.(..((.(...((((((...((((..((..(((....((.....))...)))..).)..))))..))))))....).))...)..)..(((((((((....)))))))))}........ 28S human mitochondrial small ribosomal subunit with mtRF1 and P-site tRNA; 12S rRNA 8ois AG 71 3.0 URS0000D77905_9606 37141370 9606 aguaaggucagcuaaauaagcuaucgggccnauaccccgaaaauguugguuauacccuucccguacuacca <<<<.<<..<<<<.....>>>>.<<<<<.......>>>>>....<..<<......>>..>>>.>>>>.... ((((.((..((((.....))))..((((.......)))).....(..((......))..))).)))).... 28S human mitochondrial small ribosomal subunit with mtRF1 and P-site tRNA; P-site Met-tRNA(Met) 8ois AI 33 3.0 37141370 9606 nnnnaugaggnnnnnnnnnnnnnnnnnnnnnnn ................................. ................................. 28S human mitochondrial small ribosomal subunit with mtRF1 and P-site tRNA; mRNA 8oit B8 1558 2.9 RF02541 URS00021ED93A_9606 37141370 0003735 0005840 9606 gcuaaaccuagccccaaacccacuccaccuuacuaccagacaaccuuagccaaaccauuuacccaaauaaaguauaggcgauagaaauugaaaccuggcgcaauagauauaguaccgcaagggaaagaugaaaaauuauaaccaagcauaauauagcaaggacuaaccccuauaccuucugcauaaugaauuaacuagaaauaacuuugcaaggagagccaaagcuaagacccccgaaaccagacgagcuaccuaagaacagcuaaaagagcacacccgucuauguagcaaaauagugggaagauuuauagguagaggcgacaaaccuaccgagccuggugauagcugguuguccaagauagaaucuuaguucaacuuuaaauuugcccacagaacccucuaaauccccuuguaaauuuaacuguuaguccaaagaggaacagcucuuuggacacuaggaaaaaaccuuguagagagaguaaaaaauuuaacacccauaguaggccuaaaagcagccaccaauuaagaaagcguucaagcucaacacccacuaccuaaaaaaucccaaacauauaacugaacuccucacacccaauuggaccaaucuaucacccuauagaagaacuaauguuaguauaaguaacaugaaaacauucuccuccgcauaagccugcgucagauuaaaacgaacugacaauuaacagcccaauaucuacaaucaaccaacaagucauuauuacccucacugucaacccaacacaggcaugcucauaaggaaagguuaaaaaaaguaaaaggaacucggcaaaucuuaccccgccuguuuaccaaaaacaucaccucuagcaucaccaguauuagaggcaccgccugcccagugacacauguuuaacggccgcgguacccuaaccgugcaaagguagcauaaucacuuguuccuuaanuagggaccuguaugaauggcuccacgaggguucagcugucucuuacuuuuaaccagugaaauugaccugcccgugaagaggcgggcauaacacagcaagacgagaagacccuauggagcuuuaauuuauuaaugcaaacaguaccuaacaaacccacagguccuaaacuaccaaaccugcauuaaaaauuucgguugnggcgaccucggagcagaacccaaccuccgagcaguacaugcuaagacuucaccagucaaagcgaacuacuauacucaauugauccaauaacuugaccaacggaacaaguuacccuagggauaacagcgcaauccuauucuagaguccauaucaacaauaggguuuacgaccucgauguuggaucaggacaucccgauggugcagccgcuauuaaagguucguunnuucaacgauuaaaguccuacgugaucugaguucagaccggaguaauccaggucgguuucuaucuacuuucaaauuccucccuguacgaaaggacaagagaaauaaggccuacuucacaaagcgccuucccccguaaaugauaucaucucaacuuaguauuauacccacacccacccaagaacaggguuugu <<<.......<<<<.....................................<......>...............<<.....>>.............>>.>>.............<<....>>......................>>>...........<<<.......>>>...<.<........>.>.<<<<<<.........<<<.<<..<<....>>...>>.>>>...<<.<..<<<<<.<.....<<<<<.<<<..<<<.....>>>...<<<..<<<<........>>>>.>>>....>>>.>>>>>...<<.......>>......>.>>>>...>..>.>>..<<<<<<....<<<<....>>>><<<.<<<<<<<<<<.....<<..........>>.....>>>>>>>>>>..>>>.<<<<<<<<<<......>>>>>>>>>>...<<<......>>>....<<<.<<<...<..............<....<<<.........>>>....>.......<<<......>>>....................................>...>>>>>>........>>>>>>...<<<<<......>>>>>.........>>>>>><......<<..<<<....>>><<<<..<<<<........<<<<<..<.....>..>>>>>......<<<...<<<<.......................>>>>.......>>>.....<<......>>.>>>>.....>>>>..<<<<...<<<<<<<<.<<.........<......<<<<<<..<<<.........>>>...<<<<<<.............>>>>>>....<<<.<<<..<<<<<....>>>..>>>>><<<<<<......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>....>>.>>>>.....>..>>.>>>>>>>>>>>>.>>.....>.....<<<<<........>>>>>.......<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<....<<<........<<<....>>>.......>>>......>>>>>>>>>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<.....<<<..<<<<.....>>>>..>>>...........>>.........<<<....>>>............>>>>..>>>>>>.......<<<..<.<<<<<<...<<.......>>...>>>>>>...>.>>.>.......<.<<<.<<<<<<..<<.<<<<<<......>>>>>>...>>.<<<<<.....>>>>>.....>>>>>..>...>>>..>....<<<<<<<....>>>.>>>>....>>..>>>.>>.....<<<.<<<.................>>>.>>><<<<<...<<<....>>>.>>>>>......<<<................>>>.................<<<<.......>>>>.... ((.....(..((((.....................................(...[..).........(.....((.]...))....)........)).)).............((....))....)..................)).........(.(((.......))).[.(.(........).).((((((.........(((.((..((....))...)).)))...((.(...((((.(.....(((((.((((.(((....[)))...(((..((((.......{)))).)))..).))).))))).(.((.......))...)..).))))......).))..((((((....((((....)))).((.((((((((((.....((..........)).....))))))))))..))..((((((((((......))))))))))...(((......)))....(((.(((...(..............(.(..(((.........)))..).)....(..(((......))))...................................)...))))))........))))))...(((((......))))).........))))))(......((..(((....)))(((...((((......(.(((((.((.....)).)))))......(((...((((...............(..)....)))).......))).)...((......)).))))......)))..((((....(((((((.((..(....(........((((((.].((.........))....((((((.............))))))....(((.(((..(((((....)))..)))))(((((........)))))........((..........(((((.......)))))..)..)....)))....)).))))....)..))).))))))).)))).)).....)).{..(((((.....]}.))))).......((..(((.((......((((.((((((..(((((.((((((((....(((........(((....))).......)))......)))))))))))))..(((......[)))((((((..........]))))))(.((.....((...(((....[..)))...))...........)).........(((....))).....)].....))))..))))))......((((..(.((((((.(.((.......)))..))))))...).)).).)......(.((.((((((..((.((((((......))))))...)).(((((.....))))).....)))))..)...))..).....(((((((....))).))))..}.))..))).))...(.(((.(((......(....).....))).)))(((((...(((....))).)))))......(((................)))......).........(((((.......))))..). 39S human mitochondrial large ribosomal subunit with mtRF1 and P-site tRNA; 16S rRNA 8oit AG 71 2.9 URS0000D77905_9606 37141370 9606 aguaaggucagcuaaauaagcuaucgggccnauaccccgaaaauguugguuauacccuucccguacuacca <<<<.<<..<<<<.....>>>>.<<<<<.......>>>>>....<..<<......>>..>>>.>>>>.... ((((.((..((((.....))))..((((.......)))).....(..((......))..))).)))).... 39S human mitochondrial large ribosomal subunit with mtRF1 and P-site tRNA; P-site Met-tRNA(Met) 8oj0 5 3474 3.3 RF02543 38383785 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccgcuccccggcggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucgggggcccccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcgcucuccccccggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccggggggccacgcgcgcgucccccgggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgccggccgaggugggaucccgaggccucuccaguccgccgagggcgcaccaccggcccgucucgcgggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcagacccgacgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcgccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgcccucggccgaucgaaagggagucggguucagauccccgaauccggagcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcugguagcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacaugagagguguagaauaagugggaggcccgccggugaaauaccacuacucugauguuuuuucacugacccggugaggcgggggggcgaucucgcuucuggcgccaagcgcccggccgcggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccgguccccgggguccggugcggagugcccuucguccugggaaacggggcgcggcuggaaaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>>..<<<<<<<<<<...<<<<<<.<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>.....>>>>>>..>>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<<<..<<<<<<<...>>>>...>>>>>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<<<<<<<<<<<<<<<<<...<<..<<<..<.<<<<......<<<<<<<<..>>>>>>>>.......>>>>.>.>>>........>>>>>>..>>>>>>>>>>>....................<<<<<<.<<<<<..>>>>>.<<<<<<.<<<<.<<<<<<<<<<<<<<<<<<<<<<<<.<<<<....>>>>.>>>>>>>>>>>.>>>>>>>>>>.>>>...>>>>>>>>.>>..<<<<<<<<<..>>>>>>>.>>....>>>>>>.....>>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<..>>>>>>..<<<<<...<<<..<<<..((((.((((>>>..>>>....>>>>>.<<<<<<<<<....>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<.............<<<.<<<<<<<<<...<<<....<<<..<.<<<..<<<<<<.<<...>>.>>>>>>>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>>>>>>.>>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<..>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<..........)))).))))...............>>>>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<..>>>>>......>>....>>>..<<<<<........>>>>>))<<<<.<<<<<..<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<...............<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<....>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<..>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<<<<<<.<<<<...........<..<<..................>>..>.>>>>.>>>>>>>>>>>>...<<<<<.....<<<<..<<.<..>>>..............<<<<<<<<<<..>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>>.<<<....>>>.>>)))].....<<<<<<<..<<<..)))))).>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<.]]]..>>>>..>>.>>...>>>>...>>>><<<<....<<<<<...........>>>>>....>>>>.>>>...>.>>>>>>.....<<<<<<<.<<..<<<<....<<<........<<<<<.<<<<>>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>..............>>>>..>>>>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<.<..<<<<..>>>>..>>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((...((((((((((.....)))))).)))).....)))....((((((((((...(((((.(((((((((..({((((......)))))....[[(...).(((....}]])))...).)))))))....).)))))..))))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((..(...((((((((.(((.....(((((((((((..(((((((.()))))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((..(.((((......((((((((())))))))).......)))).).)))........))))))..)))))))))))....................((((((.(((((()))))).((((((.((((.(((((((((((((((((.(((((..((((....))))..))))).)))).)))))))))).)))...)))))))).))..(((((((((()))))))).))..[.)))))).....))).)))))...).)))...)))))))).<((((........))))((((((....(((((((((((((..(((..(((((........))))..)..)))...((....))...((((((()))))))..(((((...(((..(((..[[[[.[[[[)))..)))....))))).(((((((((.().))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((.............(((.((((((((....(((....(((..(.(((..((((((.(.....).))))))))).)..)))..)).)....))))))...(((((((((.(......))))))))))....))))))))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.....{.(())...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((..........]]]].]]]]].(...)........)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...((....(((....)))..........((.(((())))))......))....))...(((((........)))))]]((((.(((((...(((((((....)))))))..((((....)))...(...((((((...(((((((((((((((((((((((..{{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((....)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((())))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.(((((((((.((((((((((((.((((...........(..((..................))..).)))).))))))))))))...(((((.....((((..(..(()).)..............((((((((((()))))))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((.(.(..(((((...((.......))...)))))....)).).)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a.))..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}}.)))))..)).))...))))...)))).((((...((((.....}.......))))...))))..)))...).)))))).....(((((((.((..((((.(..(((........(((((.(((()))).))))).......)))...(((..((((....((((.(((((.(......).)))))))))...))))..)))...........)..))))..)))))))))(((((.(..(.......)..)....((.(((((((.((.....((((.(..((((()))))..)))))....))....)))).))).))..))))).. 60S ribosomal subunit bound to the E3-UFM1 complex - state 2 (native); 28S rRNA 8oj0 7 120 3.3 RF00001 38383785 0003735 0005840 9606 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. 60S ribosomal subunit bound to the E3-UFM1 complex - state 2 (native); 5S rRNA 8oj0 8 148 3.3 RF00002 38383785 0003735 0005840 9606 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacaugaucaucgacacuucgaacgcacuugcggccccgggcccggggcuacgccugucugagcgucgcu .........................................<<<<<<<<<....>>>>.....<.<<<......>>..........>>>..>...>>>....<<....>><<<<<<<<<>>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]]..........)))..)...)))....((....))((((((((())))))))).................... 60S ribosomal subunit bound to the E3-UFM1 complex - state 2 (native); 5.8S rRNA 8oj3 1 3218 3.5 RF02540,RF02541,RF02543 0003735 0005840 5476 ugaccucaaaucagguaggacuacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaacagggauugccucaguagcggcgagugaagcggcaaaagcucaaauuugaaaucuggcgucuuuggcguccgaguuguaauuugaagaagguaucuuugggcccggcucuugucuauguuccuuggaacaggacgucacagagggugagaaucccgugcgaugagaugacccgggucuguguaaaguuccuucgacgagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcuugagaucagacuugguauuuugcaugcgguuuaccgggccagcaucgguuuggagcggcaggauaauggcggaggaauguggcacggcuucugcuguguguuauagccucugacgauacugccagccuagaccgaggacugcgguuuuuaccuaggauguuggcauaaugaucuuaagucgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccguacgcguaaugaaagugaacgaaggugggggcccauuagggugcaccaucgaccgauccugauguguucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagaagucuugggguugaaaugaccuuaacuuauucucaaacuuuaaauauguaagaaguccuuguugcuuaauugaacguggacaauugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacgugaaguuaaagugccggaaugcacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcgugcuacuuauacuucaccgugauugcuguuuugacgcuuucacgaguaggcaggcguggaggucagugacgaagccuuugcuguaaagcugggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccaugucaacagcaguuggacauggguuagucgauccuaagagauggggaagcuccguuucaacgugcuugauuuuucaggccaaccaucgaaagggaauccgguuaaaauuccggaacuuggauauggauucuucacggcaacguaacugaauguggagacgucggcgugagcccugggaggaguuaucuuuucuucuuaacagcuuaucacccuggaauugguuuauccggagauggggucuuauggcuggaagagcgcgguaauuuugccgcguccggugcgcuuacgacgguccuugaaaauccacaggaaggaauaguuuucaugccaagucguacucauaaccgcagcaggucuccaagguuaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaaggaucgguuuaacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugugauggucagaaagugauguugacacaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaaaagacauggaggguguagaauaagugggagcuucggcgccggugaaauaccacuaccucuauaguuuuuuuacuuauucaaugaagcggagcuggaggucaaacuccacguucuagcauuaagcccucugggcgauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagguguccuaagggggacucauggagaacagaaaucuccaguagaacaaaaggguaaaaguccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaucgcaauaguaauugaacuuaguacgagaggaaccguucauucagauaauugguuuuugcggcugucugaucaggcaacgccgcgaagcuaccaucugcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcgaugauuuuugcccugcacauuuuagauggauacgaauaagacuuuuuagucgcuggaccauagcaggcuggcaacggugcgcuuagcggaaaggcuuugugcgcuugccggcggauagcaaugucaacaugcgcggggauaaauccuuugcauacgacuuagauguacaacggaguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagcucuuguugucugauuugu .......................<<<<<<.....<......>......>>>>>.>...{.....<<....>>..<<<<<......<.......>.....>>>>>..[[[..<........<<.<<<<<<...>>>>>>.>>........>....<<<<<...<<<<<<<<<<<<.<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>....>>>>>>>>....>>>>..>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]....}.............................<<....>>...............<<<<....>>>>..................................<<<<<<<<<<<<.....<<<<..<<<<..>>>>..>>>>..<<<<<<<.<<<<<<<<.<<<<<<<....<<.<<<<<<<......<<<<<<......>>>>>>.......>>>>>>.>.>>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<..<<<<<.....>>>>>..>>>...<<....>>.......<<<<<..<<<<....>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<.......>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<..<<.........>>..>>>>>....>>>>>><.<<<<<<<<.<<......<<<<..<<<....>>>.>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<<<<<....>>>>>>......>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<....<....>.....>>>>><<.<<<<<<<<<<<......>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<<...<.<<............................................>>.>...>>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>..............<<<<...>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<.................>>>>>..<<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.....<<<<<<.<<<.......<<..........<<<......>>>......>>.......<<<<<<...<<<<<<<..<<<......>>>..>>>>>>>.>>>>>>................>>>.>>>>>>..<<<<<<<.............>>....<<<<<<<<<.<<<....<<<<.<..<<<<<......>>>>>..>>>>>...>>>....>>>>.>>>>>..>>>>>.. .......................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........(((((...((((((.(((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))).)..))))).))....))))..)))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((((((..(..((((..(.((())).)..))))).((((((((((((((((.(((((((........((((((......((((((......)))))).......))))))......))))).))))))))))........(((....)))....))))))))....)))))))))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..((((....))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((........)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((....((.(((((((.....(((....(((..(.((((...((((.(.....).)))).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((..((.........))..)))))....))))))(.((((((((.((......((((..(((....))).))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........(.((.((......)).))).....))....))...(((((........)))))]]((((..(((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((......)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(..(((.....((((....)))).....))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.((....(.((............(...(......)...............)..))..)...)).)))))))....((((.....((((..(((((......)))))...........>..((((...))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))....))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).....((((((.(((.......((.(........((((....)))).....))).......((((((...(((((.(..(((......)))..).))))).))))))................))).))))))..(((((((..(.......)..))..(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Crystal structure of the Candida albicans 80S ribosome in complex with geneticin G418 (rotated state); 25S ribosomal RNA 8oj3 3 121 3.5 RF00001 0003735 0005840 5476 gguugcggccauaucuagcagaaagcaccguuccccguucgaucaaccguaguuaagcugcuaagagcaauaccgaguaguguagugggagaccauacgcgaaacuauugugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of the Candida albicans 80S ribosome in complex with geneticin G418 (rotated state); 5S ribosomal RNA 8oj3 4 156 3.5 RF00002 0003735 0005840 5476 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaauaugaauugcagauauucgugaaucaucgaaucuuugaacgcacauugcgcccucugguauuccggagggcaugccuguuugagcgucgu .........................................<<<<<<.((.....>>>.....<.<<<<.....))............>>.>>..>...>>>....<<.....>><<<<<<<<<....>>>>>>>>>................... .........................................((((((.[[.....))).....(.((((.....]]............)).))..)...)))....((.....))(((((((((....)))))))))................... Crystal structure of the Candida albicans 80S ribosome in complex with geneticin G418 (rotated state); 5.8S ribosomal RNA 8oj3 B 1708 3.5 RF01960,RF02542,RF01959,RF00177 0003735 0005840 5476 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauagucuacuuggauaaccgugguaauucuagagcuaauacaugcuuaaaaucccgacuguuuggaagggauguauuuauuagauaaaaaaucaaugccuucgggcucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaaucccgacacggggagguagugacaauaaauaacgauacagggcccuuuugggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaaaagcguauauuaaaguuguugcaguuaaaaagcucguaguugaaccuugggcuuggcuggccgguccgcguacuggacccagccgagccuuucccuuuuacuuugaaaaaauuagaguguucaaagcaggccuuugcucgaauauauuagcauggaauaauagaauaggacguuaugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucggggguaucaguauucaguugucagaggugaaauucuuggauuuacugaagacuaacuacugcgaaagcauuuaccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgguuguuguucuuugacgcaaucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauagugcugcuagcauuugcugguauagucacuucuuagagggacuaucgauuucaagucgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgaguauaagccuuggccgagaggucugggaaaucuugugaaacuccgucgugcuggggauagagcauuguaauuguugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuacuaccgauugaauggcuuagugaggccuccggauugguuaaccgagaagcuggucaaacuuggucauuuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucau ...<<<<<.{.((((>>>>><<<<.<<<<<<...<.<...<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<..<<..<<....<<<.........<<.....<..<<<.....>>>..>......>>........<<<<<..<<....>>..>>>>><...<<<<<<.........((((.<<<....>>>..............>>>>>>.....>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>....>.>.....<<<<<<<<.<<<<....>>>>.>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>>.........<<<[[.....<.<<...<<<.<<....<<<<<<<<<<.....<........>.......>>>>>>>>>>.......<<<<<.<<.......<<...<.......>..<<<....>>>....>>......>>.>>..>>>.........<<<..<<<<<<<<......)))).....>>>>>>>>>>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<..<<....>>.>>>>>>>>..>>>...<<..]]>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..)))).}<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<......<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<.....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<.<<<<<<<....>>>>>>>....>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>.....>>.>>>.....>>>>>>>.......>>>>>...>>.>>>>.>>>.....<<<<<<<......<<......<<<.<<<<....>>>>.>>>....>>.......>>>>>>>......<....<<<<<<..........>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<..<...<<<<<..>>>>>...>..>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>....... 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Crystal structure of the Candida albicans 80S ribosome in complex with geneticin G418 (rotated state); 18S ribosomal RNA 8oj3 AS 3101 3.5 RF02540,RF02541,RF02543 0003735 0005840 5476 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Crystal structure of the Candida albicans 80S ribosome in complex with geneticin G418 (rotated state); 25S ribosomal RNA 8oj3 AT 121 3.5 RF00001 0003735 0005840 5476 gguugcggccauaucuagcagaaagcaccguuccccguucgaucaaccguaguuaagcugcuaagagcaauaccgaguaguguagugggagaccauacgcgaaacuauugugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Crystal structure of the Candida albicans 80S ribosome in complex with geneticin G418 (rotated state); 5S ribosomal RNA 8oj3 AU 158 3.5 RF00002 0003735 0005840 5476 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaauaugaauugcagauauucgugaaucaucgaaucuuugaacgcacauugcgcccucugguauuccggagggcaugccuguuugagcgucguuu .........................................<<<<<<.((.....>>>.....<.<<<<.....))............>>.>>..>...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(..(((.....]]............)).)...)...)))....((.....))(((((((((....)))))))))..................... Crystal structure of the Candida albicans 80S ribosome in complex with geneticin G418 (rotated state); 5.8S ribosomal RNA 8oj3 CM 1728 3.5 RF01960,RF02542,RF01959,RF00177 0003735 0005840 5476 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguauacuuggauaaccgugguaauucuagagcuaauacaugcuuaaaaucccgacuguuuggaagggauguauuuauuagauaaaaaaucaaugccuucgggcucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaaucccgacacggggagguagugacaauaaauaacgauacagggcccuuuugggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaaaagcguauauuaaaguuguugcaguuaaaaagcucguaguugaaccuugggcuuggcuggccgguccauaugcguacuggacccagccgagccuuuccuucuggguaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggccuuugcucgaauauauuagcauggaauaauagaauaggacguuaugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucggggguaucaguauucaguugucagaggugaaauucuuggauuuacugaagacuaacuacugcgaaagcauuuaccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgguuguuguucuuugacgcaaucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauagugcugcuagcauuugcugguauagucacuucuuagagggacuaucgauuucaagucgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgaguauaagccuuggccgagaggucugggaaaucuugugaaacuccgucgugcuggggauagagcauuguaauuguugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuacuaccgauugaauggcuuagugaggccuccggauugguuaaccgagaagcuggucaaacuuggucauuuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucau ...<<<<<.{.((((>>>>><<<<.<<<<<<...<.<...<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<..<.....<<<..<<..<<....<<<.........<<.....<..<<.......>>..>......>>........<<<<<..<<....>>..>>>>><...<<<<<<..........(((.<<<....>>>..............>>>>>>.....>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>>>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>....>.>.....<<<<<<<<<<..........>>>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>>.........<<<[[.....<.<<...<<<.<<....<<<<<<<<<<.........<..>.............>>>>>>>>>>.....<<<<<....>>>>>....<<<<<.<<.......<<...<.......>..<<<....>>>....>>......>>.>>..>>>.........<<<..<<<<<<<<<.....))).....>>>>>>>>>>>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<..<<....>>.>>>>>>>>..>>>...<<..]]>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..)))).}<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<.....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<.<<<<<<<....>>>>>>>....>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>.....>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<......<<<.<<<<....>>>>.>>>....>>.......>>>>>>>......<....<<<<<<..........>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<..<...<<<<<..>>>>>...>..>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>....... ....(((..[.[[[..))).((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((.........((.....(..(((.....)))..)......))........(((((..((....))..)))))(.(.(((((...........[[[.(((....))).....(......)..))))).)...).(..(((..((((..).))).))).)...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(((((((.(((.......).)).)))).)))....(.(((.(...........)).))......)..((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....(((((.((((....(..(..().)....).......)))).)))))......((((....)))).....(((((.((.(.....((..((.......)).(((....)))....))..)...)).))..))).........(((..(((((.((......]]]......)).)))))))).....))....((..((..(...((((...(..((((((.....((........))........))))))..)........((....))...))))..)..))...))...)))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((..(......).))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.........(.(((........))).).......)))))...((.(((...(..((((.....(((.(((((....)))..(.((......)))...)).)))....(((((.((...(((..((((((.(((((....))))).)..).))))..)))..))..(.((((((.....))))))....)..))))).....)).))......).))))).....).)))))...)).)))).))).(...(((((((......((......(((.((((....)))).)))....)).......)))))))......(....((((((..........))))))....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..((((..(...(((((())))))...)..))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>...... Crystal structure of the Candida albicans 80S ribosome in complex with geneticin G418 (rotated state); 18S ribosomal RNA 8oj5 5 3474 2.9 RF02543 38383785 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccgcuccccggcggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucgggggcccccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcgcucuccccccggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccggggggccacgcgcgcgucccccgggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgccggccgaggugggaucccgaggccucuccaguccgccgagggcgcaccaccggcccgucucgcgggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcagacccgacgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcgccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgcccucggccgaucgaaagggagucggguucagauccccgaauccggagcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcugguagcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacaugagagguguagaauaagugggaggcccgccggugaaauaccacuacucugauguuuuuucacugacccggugaggcgggggggcgaucucgcuucuggcgccaagcgcccggccgcggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccgguccccgggguccggugcggagugcccuucguccugggaaacggggcgcggcuggaaaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>>..<<<<<<<<<<...<<<<<<.<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>.....>>>>>>..>>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<......>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<<<..<<<<<<<...>>>>...>>>>>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<.<<<<<<<<<<<<<<<...<<..<<<..<.<<<<......<<<<<<<<..>>>>>>>>.......>>>>.>.>>>........>>>>>>..>>>>>>>>>>>....................<<<<<<.<<<<<..>>>>>.<<<<<<.<<<<.<<<<<<<<<<<<<<<<<<<<<<<<.<<<<....>>>>.>>>>>>>>>>>.>>>>>>>>>>.>>>...>>>>>>>>.>>..<<<<<<<<<..>>>>>>>.>>....>>>>>>......>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<..>>>>>>..<<<<<...<<<..<<<..((((.((((>>>..>>>....>>>>>.<<<<<<<<<....>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<.............<<<.<<<<<<<<<...<<<....<<<..<.<<<..<<<<<<.<<...>>.>>>>>>>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<..>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<..........)))).))))...............>>>>>>>>>....>>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<..>>>>>......>>....>>>..<<<<<........>>>>>))<<<<.<<<<<..<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<....>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<..>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<<<<<<.<<<<...........<..<<..................>>..>.>>>>.>>>>>>>>>>>>...<<<<<.....<<<<..<<.<..>>>..............<<<<<<<<<<..>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>><<<<....>>>>>>)))].....<<<<<<<..<<<..)))))).>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<.]]]..>>>>..>>.>>...>>>>...>>>><<<<....<<<<<...........>>>>>....>>>>.>>>...>.>>>>>>.....<<<<<<<.<<..<<<<....<<<........<<<<<.<<<<>>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>..............>>>>..>>>>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<....<<<<..>>>>...>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((...((((((((((.....)))))).)))).....)))....((((((((((...(((((.(((((((((..({((((......)))))....[[(...).(((....}]])))...).)))))))....).)))))..))))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....(((((((((((..(((((((.()))))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((..(.((((......((((((((())))))))).......)))).).)))........))))))..)))))))))))....................((((((.(((((()))))).((((((.((((.(((((((((((((((((.(((((..((((....))))..))))).)))).)))))))))).)))...)))))))).))..(((((((((()))))))).))..[.)))))).....))).)))))...)))))...)))))))).<((((........))))((((((..(.(((((((((((((..(((..(((((........))))..)..)))...((....))...((((((()))))))..(((((...(((..(((..[[[[.[[[[)))..)))....))))).(((((((((.().))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))..).))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((.(((((((.............(((.((((((((....(((....(((..(.(((..((((((.((...)).))))))))).)..)))..)).)....))))))...(((((((((.(......))))))))))....))))))))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.....{.(())...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((..........]]]].]]]]].(...)........)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...((....(((....)))..........((.(((())))))......))....))...(((((........)))))]]((((.(((((...(((((((....)))))))..((((....)))...(...((((((...(((((((((((((((((((((((..{{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((....)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((())))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.(((((((((.((((((((((((.((((...........(..((..................))..).)))).))))))))))))...(((((.....((((..((.(..)))..............((((((((((()))))))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a.))..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}}.)))))..)).))...))))...)))).(((....((((.....}.......))))....)))..)))...).)))))).....(((((((.((..((((.(..(((........(((((.(((()))).))))).......)))...(((..((((....((((.(((((.(......).)))))))))...))))..)))...........)..))))..)))))))))(((((.(..(.......)..)....((.(((((((.((.....((((.(..((((()))))..)))))....))....)))).))).))..))))).. 60S ribosomal subunit bound to the E3-UFM1 complex - state 3 (in-vitro reconstitution); 28S rRNA 8oj5 7 120 2.9 RF00001 38383785 0003735 0005840 9606 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. 60S ribosomal subunit bound to the E3-UFM1 complex - state 3 (in-vitro reconstitution); 5S rRNA 8oj5 8 148 2.9 RF00002 38383785 0003735 0005840 9606 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacaugaucaucgacacuucgaacgcacuugcggccccgggcccggggcuacgccugucugagcgucgcu .........................................<<<<<<<<<....>>>>.....<.<<<......>>..........>>>..>...>>>....<<....>><<<<<<<<<>>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]]..........)))..)...)))....((....))((((((((())))))))).................... 60S ribosomal subunit bound to the E3-UFM1 complex - state 3 (in-vitro reconstitution); 5.8S rRNA 8oj8 5 3515 3.3 RF02543 38383785 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccgcuccccggcggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcgcggcggaucuuucccggcgggggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucgggggcccccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcgcucuccccccggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccggggggccacgcgcgcgucccccgggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgccggccgaggugggaucccgaggccucuccaguccgccgagggcgcaccaccggcccgucucgcgggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcagacccgacgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcgccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgcccucggccgaucgaaagggagucggguucagauccccgaauccggagcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcugguagcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacaugagagguguagaauaagugggaggcccgccggugaaauaccacuacucugauguuuuuucacugacccggugaggcgggggggcgaucucgcuucuggcgccaagcgcccggccgcggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccgguccccgggguccggugcggagugcccuucguccugggaaacggggcgcggcuggaaaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>>..<<<<<<<<<<...<<<<<<.<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>.....>>>>>>..>>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<<<..<<<<<<<...<<<...<<<<<.<<<..<<<...>>>>>>>>>>>..>>>..>>>>...>>>>>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<.<<<<<<<<<<<<<<<...<<..<<<..<.<<<<......<<<<<<<<..>>>>>>>>.......>>>>.>.>>>........>>>>>>..>>>>>>>>>>>....................<<<<<<.<<<<<..>>>>>.<<<<<<.<<<<.<<<<<<<<<<<<<<<<<<<<<<<<.<<<<....>>>>.>>>>>>>>>>>.>>>>>>>>>>.>>>...>>>>>>>>.>>..<<<<<<<<<..>>>>>>>.>>....>>>>>>......>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<..>>>>>>..<<<<<...<<<..<<<..((((.((((>>>..>>>....>>>>>.<<<<<<<<<....>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<.............<<<.<<<<<<<<<...<<<....<<<..<.<<<..<<<<<<.<<...>>.>>>>>>>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>>>>>>.>>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<..>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<..........)))).))))...............>>>>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<..>>>>>......>>....>>>..<<<<<........>>>>>))<<<<.<<<<<..<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<...............<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<....>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<..>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<<<<<<.<<<<...........<..<<..................>>..>.>>>>.>>>>>>>>>>>>...<<<<<.....<<<<..<<.<..>>>..............<<<<<<<<<<..>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>>.<<<....>>>.>>)))].....<<<<<<<..<<<..)))))).>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<.]]]..>>>>..>>.>>...>>>>...>>>><<<<....<<<<<...........>>>>>....>>>>.>>>...>.>>>>>>.....<<<<<<<.<<..<<<<....<<<........<<<<<.<<<<>>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>..............>>>>..>>>>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<.<..<<<<..>>>>..>>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((...((((((((((.....)))))).)))).....)))....((((((((((...(((((.(((((((((..({((((......)))))....[[(...).(((....}]])))...).)))))))....).)))))..))))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....(((((((((((..((((((....(((.(.(((((.(((..(((...)))))))))))).)))...)))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((..(.((((......((((((((())))))))).......)))).).)))........))))))..)))))))))))....................((((((.(((((()))))).((((((.((((.(((((((((((((((((.(((((..((((....))))..))))).)))).)))))))))).)))...)))))))).))..(((((((((()))))))).))..[.)))))).....))).)))))...)))))...)))))))).<((((........))))((((((....(((((((((((((..(((..(((((........))))..)..)))...((....))...((((((()))))))..(((((...(((..(((..[[[[.[[[[)))..)))....))))).(((((((((.().))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((........)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((.............(((.((((((((....(((....(((..(.(((..((((((.(.....).))))))))).)..)))..)).)....))))))...(((((((((.(......))))))))))....))))))))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.....{.(())...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((..........]]]].]]]]].(...)........)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...((....(((....)))..........((.(((())))))......))....))...(((((........)))))]]((((.(((((...(((((((....)))))))..((((....)))...(...((((((...(((((((((((((((((((((((..{{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((....)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((())))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.(((((((((.((((((((((((.((((...........(..((..................))..).)))).))))))))))))...(((((.....((((..(..(..).)..............((((((((((()))))))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......(..(.(..(((((...((.......))...)))))....))...)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))....))..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}}.)))))..)).))...))))...)))).((((...((((.....}.......))))...))))..)))...).)))))).....(((((((.((..((((.(..(((.........((((.(((()))).))))........)))...(((..((((....((((.(((((.(......).)))))))))...))))..)))...........)..))))..)))))))))(((((.(..(.......)..)....((.(((((((.((.....((((.(..((((()))))..)))))....))....)))).))).))..))))).. 60S ribosomal subunit bound to the E3-UFM1 complex - state 1 (native); 28S rRNA 8oj8 7 120 3.3 RF00001 38383785 0003735 0005840 9606 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. 60S ribosomal subunit bound to the E3-UFM1 complex - state 1 (native); 5S rRNA 8oj8 8 148 3.3 RF00002 38383785 0003735 0005840 9606 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacaugaucaucgacacuucgaacgcacuugcggccccgggcccggggcuacgccugucugagcgucgcu .........................................<<<<<<<<<....>>>>.....<.<<<......>>..........>>>..>...>>>....<<....>><<<<<<<<<>>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]]..........)))..)...)))....((....))((((((((())))))))).................... 60S ribosomal subunit bound to the E3-UFM1 complex - state 1 (native); 5.8S rRNA 8oly A 390 3.11 RF02001,RF01998 URS000080E176_182710 38898052 0000373 182710 gugugcccggcaugggugcagucuauagggugagagucccgaacugugaaggcagaaguaacaguuagccuaacgcaaggguguccguggcgacauggaaucugaaggaagcggacggcaaaccuucggucugaggaacacgaacuucauaugaggcuagguaucaauggaugaguuugcauaacaaaacaaaguccuuucugccaaaguugguacagaguaaaugaagcagauugaugaagggaaagacugcauucuuacccggggaggucuggaaacagaagucagcagaagucauaguacccuguucgcaggggaaggacggaacaaguauggcguucgcgccuaagcuugaaccgccguauaccgaacgguacguacgguggugug .....<<<<<...<<<<<<<<<<<...<<<.......>>>..<<<<<...(((((((...>>>>>..<<<...<<<..<<<<.<<<<<<....>>>>>>>>>>.......>>>...>>>...<<<<<<<<<<<...........<<<<<......<<<..<<<<<<<<<<<<..<<<<........>>>>...>>>>.)))))))...>>>>>>>>..>>>...>>>>>>>>>>...>>>>>>...>>>>>>>>>>>....>>>>>....<<<<....>>>>...........<<<......<<<<<....>>>>>....>>>....<<<<<..<<<<....>>>>...>>>>>.<<<<<<<<<<<<<....>>>..>>>>>>>>>>... ..[<.((((({..(((((((((((...(((.......)))..(((((...[[[[[[[...)))))..(((...(((..((((.((((((....))))))))))...>}..)))...)))...(((((((((((.(.....)...(((((.....[(((..((((((((((((..((((.]......))))...)))).]]]]]]]...))))))))..)))...))))))))))...))))))...)))))))))))...])))))(...((((....))))...).......(((.(....(((........)))...))))....(((((..((((....))))...))))).(((((((((((((....)))..))))))))))... Structure of Oceanobacillus iheyensis group II intron post first step of splicing in the presence of K+, Mg2+ and intronistat B; Group IIC intron 8olz A 390 3.31 RF02001,RF01998 URS000080DF32_182710 38898052 0000373 182710 ugugcccggcaugggugcagucuauagggugagagucccgaacugugaaggcagaaguaacaguuagccuaacgcaaggguguccguggcgacauggaaucugaaggaagcggacggcaaaccuucggucugaggaacacgaacuucauaugaggcuagguaucaauggaugaguuugcauaacaaaacaaaguccuuucugccaaaguugguacagaguaaaugaagcagauugaugaagggaaagacugcauucuuacccggggaggucuggaaacagaagucagcagaagucauaguacccuguucgcaggggaaggacggaacaaguauggcguucgcgccuaagcuugaaccgccguauaccgaacgguacguacgguggugugg ....<<<<<...<<<<<<<<<<<...<<<.......>>>..(((((...<<<<<<<...)))))..<<<...<<<..<<<<.<<<<<<....>>>>>>>>>>.......>>>...>>>...[[[[[[[[[[[...........[[[[[......[[[...(((((((<<<<..<<<<........>>>>...>>>>.>>>>>>>...)))))))...]]]...]]]]]]]]]]...]]]]]]...>>>>>>>>>>>....>>>>>....<<<<....>>>>...........<<<......<<<<<....>>>>>....>>>....<<<<<..<<<<....>>>>...>>>>>.<<<<<<<<<<<<<....>>>..>>>>>>>>>>.... .[<.((((({..(((((((((((...(((.......)))..((((....[[[[[[[....))))..(((...(((..((((.((((((....))))))))))...>}..)))...)))...(((((((((((.(.....)...(((((......(((...(((.(((((((..((((........))))...)))).]]]]]]]...))).)))...)))...))))))))))...))))))...)))))))))))...])))))(...((((....))))...).......(.(.(....(((.(....).)))...)).)....(((((..((((....))))...))))).(((((((((((((....)))..)))))))))).... Structure of Oceanobacillus iheyensis group II intron in the presence of K+, Mg2+, 5'-exon, and intronistat B after 2h30 soaking; DOMAINS 1-5 8oo0 1 3191 3.1 RF02543 URS000051B013_759272 38267453 0003735 0005840 209285 guugaccucggaucagguaggaggacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaacagggauugcccuaguaacggcgagugaagcggcaacagcucaaauuugaaagcuggcuucggcccgcguuguaauuuggagaggaugcuuugggcgaggcuccuucugaguucccuggaacgggacgccacagagggugagagccccguauaguuggaagccaagccuguguaaagcuccuucgacgagucgaguaguuugggaaugcugcucaaaaugggagguaaauuucuucuaaagcuaaauaccggccagagaccgauagcgcacaaguagagugaucgaaagaugaaaagcacuuugaaaagaggguuaaauagcacgugaaauuguugaaagggaagcgcuugugaccagacuugcgcccggcggaucauccgguguucucaccggugcacuccgccgggcucaggccagcaucgguucuggcggggggauaaaggcccagggaauguggcuccuccgggaguguuauagcccuggguguaauacccucgccgggaccgaggaccgcgcucugcaaggaugcuggcguaauggucaccagcgacccgucuugaaacacggaccaaggagucaagguuuugcgcgaguguuuggguguaaaacccgcacgcguaaugaaagugaacguaggugagagcuucggcgcaucaucgaccgauccugauguauucggauggauuugaguaggagcguuaagccuuggacccgaaagauggugaacuaugcuuggauagggugaagccagaggaaacucugguggaggcucgcagcgguucugacgugcaaaucgaucgucaaaucugagcaugggggcgaaagacuaaucgaaccaucuaguagcugguuaccgccgaaguuucccucaggauagcagugucgaccuucaguuuuaugagguaaagcgaaugauuagggacucgggggcgauuuuuagccuucauccauucucaaacuuuaaauauguaagaagcccuuguuacuuaacugaacgugggcauucgaauguaucgacacuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacgcgggguuaaggugccggaguggacgcucaucagacaccacaaaaggcguuaguacaucuugacagcaggacgguggccauggaagucggaauccgcuaaggacuguguaacaacucaccugccgaauguacuagcccugaaaauggauggcgcucaagcgucccacccauaccccgcccucaggguagaaacgaugcccugaggaguaggcggccguggaggucagugacgaagccuagggcgugagcccgggucgaacggccucuagugcagaucuuggugguaguagcaaauacuucaaugagaacuugaaggaccgaaguggggaaagguuccaugugaacagcgguuggacauggguuagucgauccuaagccauagggaaguuccguuucaaaggggcacucgugccccguguggcgaaagggaagccgguuaauauuccggcaccuggauguggguuuugcgcggcaacgcaacugaacgcggagacgacggcgggggccccgggcagaguucucuuuucuucuuaacggucuaucacccuggaaacaguuugucuggagauaggguuuaauggccggaagagcccgacacuucugucggguccggugcgcucucgacgucccuugaaaauccgcgggagggaauaauucucacgccaggucguacucauaaccgcagcagguccccaaggugaacagccucugguugauagaacaauguagauaagggaagucggcaaaauagauccguaacuucgggaaaaggauuggcucuaaggguugggcacguugcggcgugcgguuaacaaccaacuuagaacugguacggacagggggaaucugacugucuaauuaaaacauagcauugcgauggccagaaagugguguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcaaaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaaaagacauaggagcuccuauuguuuuuuuacuuauucaaugaagcggggcuggacuugcguccaacuucuggaguuaagguccuucgcgggccgacccggguugaagacauugucagguggggaguuuggcugnggcggcacaucuguuaaaccauaacgcagguguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaaguccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucgaaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaacucgucgcaaugguaauucagcuuaguacgagaggaaccgcugauucagauaauugguuuuugcgguuguccgaccgggcagugccgcgaagcuaccaucugcuggauaauggcugaacgccucuaagucagaauccaugccagaacgcgacgauacuacccgcacguuguagacguauaagaauaggcuccggccucguauccuagcaggcgauuccuccgccggccucgaaguggccgucgguaauucgcguauugcaauuuagacacgcgcgggaucaaauccuuugcagacgacuuagaugugcgaaaggguccuguaagcaguagaguagccuuguuguuacgaucugcugaggguaagcccuccuucgccuagauuu 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.........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.(((....))).))....)........(((((.(((((((((..((((((..((..({((((......)))))[[(...).(((....}]])))....))..)).))))..))))....)))))))).))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((.((((((.....((.(((((((((.(...((((((....))))))...)..))))))))).)).(((((((((((((((((((((((.......((((((((......(((((....))))).......))))))))......)))))))))))))))........((...))....)))))))).....)))))).)))).<((((........))))((((((....((((((((.((((..(((...(((.......)))...)))...((....)).......(((((..((....))...))))).((((((((....(....)....))).))).))....)))).))))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)<)))...(((..((.((........)))).)))....))))))))).(.((.......))...)..))))))......).))...(((((....(.(((....))).)(((((((((.....((.(((((((.....(((....(((..(.(((...(.(((((.....).)))).).))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))...))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((..((....(.........)....))......(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((..(((((((...((.....)).))))))....[[(((.((...(((...(((....)))........(((((......)))))....)))....))...(((((........)))))]]((((..(((.(((...((((....)))...(.[[((((((...((((.(((((((((((((.((((...{{..)))).)(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....)))...))).)))).))).))).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((.((((...()...))))......)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.((((((((..((.(((((((((((((()))))).)))))))).))....((((.....((((..(((((....)))))..........]]..(((((.....)))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(..(((((...((.......))...)))))....)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))....))..))).)))))....(((((((..(((..(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...))))..)))....))))))).....(((((.((..((....(.((.......(((....)))....))).......((((.....(((.(((((.......))))).)))....))))..............)).)).)))))...(((((((..(.......)..))..(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....))))..))))))..))))) Chaetomium thermophilum Methionine Aminopeptidase 2 autoproteolysis product at the 80S ribosome; 28S rRNA 8oo0 2 1765 3.1 RF01960,RF02542,RF01959,RF00177 URS0002311978_759272 38267453 0003735 0005840 759272 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...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((.........))...)){))......(((.......(((..((..((....(((....{...((.....(..(((.....)))..)......))........(((((..........)))))(.(.((((((......[[[[[[...(((....)))......(......).)))))).)...).(}((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).)....((((((((.(((((....))))).))).)))))...(.(.(.(...........))..)......)..((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((..(....((((((((((((((.(()).))).)))))))))))....((((((....(((....(()).....)))....))))))...(((((.((.......((..((.......)).(((....)))....))......)).))..))).........(((.((.((((((......]]]]]].)))))).))))).....)....(((..((.((...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)).))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((.(....))))))))))))..)))...(...}}.)...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.(..(((......((........))..........(((((..(...(((((........((.(((........))).))......)))))....(.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..(.((..((((((((((((....))))))))..))))..)).).))..(.((((((....))))))....)..)))))....))).))).....).))))......).)))))...)).)..).))).(...(((((((......((.....(((.((((....)))).)))....)).......)))))))......(....((((((..........))))))....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..((.(..(...(((((((..((.(((((....))))).))..)))))))...)..).))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>........ Chaetomium thermophilum Methionine Aminopeptidase 2 autoproteolysis product at the 80S ribosome; 18S rRNA 8oo0 3 119 3.1 RF00001 URS00006BED5F_759272 38267453 0003735 0005840 759272 acauacgaccauaccuaguggaaaacucgggaucccguccgcucucccauagauaagccacuaagggcgggguuaguacucaggucggugacgacuggggaaucccccguguuguaugu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>...>>....>>>>>>.>><<<<<<......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>> (((((((((....((((((((.....((((((...(....)...))))...))....)))))).))((((((......(((((..((....)).))))).....))))))))))))))) Chaetomium thermophilum Methionine Aminopeptidase 2 autoproteolysis product at the 80S ribosome; 5S rRNA 8oo0 4 156 3.1 RF00002 URS000029C274_759272 38267453 0003735 0005840 759272 aaacuuucaacaacggaucucuugguucuggcaucgaugaagaacgcagcgaaaugcgauaaguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgcccgccgguauuccggcgggcaugccuguucgagcgucau .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))................... Chaetomium thermophilum Methionine Aminopeptidase 2 autoproteolysis product at the 80S ribosome; 5.8S rRNA 8ooy T 26 4.0 37620586 32630 aacgtcgtgactgggaaaaccctggc .......................... .......................... Pol I bound to extended and displaced DNA section - open conformation; Template DNA 8ooy P 18 4.0 37620586 32630 gccagggttttcccagtc .................. .................. Pol I bound to extended and displaced DNA section - open conformation; Extending Primer 8ova BA 1604 2.47 RF02543 URS00029156E1_5702 37985661 0003735 0005840 5702 agaccugaguguggcaggaccacccgcuaaacuuaagcanauuacucagcggaggaaaagaaaacaaccgugauucucucagucagcggcgagcgaagagggauucaacucguugccgaaucgggucuuauaugaccucgaacuguggcauagggcuggugcaggcguggcggaauucaauugcaaagcaaacccguugcugaacauuacaacccuucaugugnguauugagccaaagaaggugucagcccauuacagccacggagccuacgcgccuccucaagagaguagcacuguuugggaaugcagugucaagccggcagguauuugucugccaagguuaaauauagaguaggaagaccgauagcgaacaaguagcgugagcgaaaguuugaaaaguacuuuggaaagagagugacauagaaccugaaaucgugacaacgacaauggaaguaccuucauuucucggccagacccaaccucgccgcgcaauuuccuuccggggcuaacauccggugggucacugugcggguuucgaggucauggggugcgugagugggcggaauaaagggucgguguguuguguucuuccuccuucccuguccgugcgucucgacgcuggcgauggaaauggggugcccccacccgucuugnnacncggaccaaggagunanacagacgcgcaagggaggaguauugugacaacucuuuucucguacugaaagggaggugugauacacccguggcgugcgcaauuuuuugcccaacaccgaccggcccuccgugggcugcgcgcgagugugccunnuuggacccnanagguggugaacuaugccugaacaaggugaagcccggggaaaccccgguggaggccuguagcgaugcugncgugcaaaungcucguacgauuugggunucgnagcgaaagacucaucgaaccaccuaguagcugguucacgucgaaguuucccucaggauagcuggugcuugucaagaaguauugugcgguaaagcaaaugauuagagggaccuauucucaaacuuuaaangugcaaacaacccagccuuaguuauuuuaacaaggcuuuaagaauugaggcaccaagugggccuucuucgguaagcngagcaggcgaugcggaaugaaccgcuuagggauauguggcgucaaaacuugugggcucauunucgauacgugaaaaggguguugguggauauccaccggccccgaaaauggangacgcuuaagccccaugugcgugauugcccauuauuccuuuggugagggcggcuauauggugagaaaguguagcccucccgauguagacguggcgugggggugaggacgaagccgauggcgcgagccucggauggacccgccucuagugcanaunuugguuggcgunncaaagaucuaacggaauauuuuuaaaugcaacguuggauncuggagcggggaaggauuucgugccaacggcacucguacacganuuguucggucacugagcacaacguuacaccgunuuguuaggaaagugaaggugcucugaaaaggggcaacagagaaccugggaugauauuccaaaaagaauugcaugugggac ......................<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<......<<.....>>....>>>>>....<<<...<<<<<..<<<<<<<......>>>>>.>>....>>>>>.<<<...<<<<<<<<<<<<<<......<<<......<<<<.......>>>>........<<........>>......>>>.<<.......((.....>>))......>>>>>...>>>>..>>>>>.>>>..........<<<<<<<........>>>>>>>......<<<<<........>>>>>..>>>....................................<<....>>................<<<<....>>>>..................................<<<..<<<<<<.<<<<<..<<.<<<<.(<<<<<<<<<<<<<<<.....<<<.<<<<<.......>>>>>.>>>.....>>>>>>....>>>>>>..>>>..............<<<<....<<<<..<<.<.<..<....>..>>.>>..>>>>.>>>>....<<<<<..)>>>>>>....>>>>>>>>>>>..>>>.<<<<........>>>><<<<<<....<<<<<<<.<<<<<..<<<...<<<.........>>>.....>>>...<<....>>..<<<<<...>>>>>...<<.<<..<<<<....>>>>...>>.>>..<<<<<<<.....>>>>>>.>.....>>>>>.>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<.<<<....>>>.>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>...<<<<<....<.<<<....>>>.><<<<<<<<<.......<<...<<<<<<....<<<....<<<..<.<<<..>>>.>..>>>..>.>>....>>>>>>...<..<....<<.<......>>>....>..>......>>..>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>...<<<<......>>>>..<<<<<<<...<<<(((......<<.<<<<........<...........<<<.<<<<<<<<<..>>>>>>>>>>>>..........))).>....>>>>>>...........>>>...>>>>>>><<<<.<<<<<...........>>>>>........>>>>>>>>>....>>>>>..<.<<<<<<<<........<<<<..<<<....>>>.>>>.>.....>>>>>>>>..>.....>>>>>>..............<<<<<<<..................>>>>>>>....................<<<<<....<<.....>>..>>>>>.....<..........<<.<<<<<......>>>>...............<<<...>>>......>.>>..........<<<<.........>>....>>.>............. ......................(((((......(...[..).......)))).).........((....))...((((.......((.]...)).....))))....((((..((((..(.((((((......))))).).....))))).(((...((((.((((((((.(...(.((.......((((.......))))........((........)).......)))[[(...)..((.....]]))....)..))))...))))...)))).))).....)....(((((((........)))))))......(((((........)))))..)))....................................((....)).............(..((.(....).))............)......................((..((((((.(((((..((.((((.(((((((((.((((((.....(((.((((.........)))).))).....)))))).....)))))..))).).............(((....((((..((.(.(..(....)..)).))..)))).)))......[[[....))))))....)))))))))))..))..(((..........)))((((.(....((.((((.(((((..(((.(.(((.........)))....))))...((....))..((.((...)).))...((.((..((((....))))...)).))..((((((.(..)..))))).).....))))).)))).))..((.(...((((((.....((((((((((.((((...(((.(((....))).)))...).)))...(((..((.((........)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).).(((((((((......((.(.((((((....(((.....(...(.(((..))).)...)...)).)....))))))...(..(....((.........))....)..).....))).)))))))).)...((((.((.((.....)).)).))))....(((......)))...(((((((...((([[[...(..((.((((........(...........(((.(((((((((..))))))))))))..........]]].)....)))))))..........)))...)))))))((((.(((((............]]].........)))))))))....))))).)(.((((((((.(......((((..(((....))).))).)...).))))))))..).....).))))..............(((((((..................)))))))....................(((((....((.....))..))))).....(......(...((.(..((......))..................(.....).......).))....).....((((.........))....)).)............. CRYO-EM STRUCTURE OF TRYPANOSOMA BRUCEI PROCYCLIC FORM 80S RIBOSOME : PARENTAL STRAIN; LSUa rRNA 8ova AA 1919 2.47 RF01960,RF02542,RF01959,RF00177 URS0002915680_5702 37985661 0003735 0005840 5702 gaucuggnugauucugcnaguagucaunngcuuguuunaaggacuuagccaugcaugccucagaaucacugcauugcaggaaucugcgcauggcucauuacaucagacguaaucugccgccaaaauuuugcggcgcauuacuggauaacuuggcgaaacgccaagcuaauacaugaaccaaucggacgcucucuuugaugggacguccagcgaaugaaugaaauuagaaccaacgccuccacccggaggcaguaacacucagacguguugacucaauucauuccgugcgaaagccgagcugcucggcgucuacugacgaacaacugcccuaucagccagugauggccguguaguggacugccauggcguugacgggagcgggggauuaggguucgauuccggagagggagccugagaaauagcuaccacuucuacggagggcagcaggcgcgcaaauugcccaaugucgaaaaaauacgaugaggcagcgaaaagaaauagagccgaccgugugguuguuuucaaugggggauacucaaacccauucaauaucgaguaacaauuggaggacaagucuggugccagcacccgcgguaauuccagcuccaaaagcguauauuaaugcugungcuguunaaggguucguaguugaacugugggccacguaguguggugccguaccagucccguccaccucgacguguuuugacccacgcccucguggccagauacaagaaacacgggagcaguucgcaugucaugcaugggggcguccgugaauuuacugugaccaaaaagaugcgaccaaagcagucuugccgacuugaauuacaaagcaugggauaacgaagcaucagcccugggguuauguugguuuuagaaguccuugggagauuauggggccgcguuguuucguguggcgcgccgcggcuuccaggaaugaaggaggguaguucgggggagaacguacuggugcgucagaggugaaauucuuagaccgcaccaagacgaacuacagcgaaggcauucuucaaggauaccuuccucaaucaagaaccaaaguguggggaucaaagaugauuagagaccauuguaguccacacugcaaaccaugacacccaugaauuggggaacaucauuuuauuuaucaauuuacgugccuacucagcacguuucuuacuucuucacgcgaaagcuuggagguuacagucucagggggnaguacguucgcaanagugaaacuuaaagaaauugacggaauggcaccacaagacguggagcgugcgguuuaauuugacncaacacggggaacuuuaccagauccggacagggugaggauugacagauggaguguncuuucucgauccccugaauggugnugcauggccgcuuuuggucggugnagugauuuguuugguugauuccgucaacggacgagauccaagcugcccaguaggugccgggauuguccacacaggacagcaguccucgucauccuucuuuuuucaggccccuucucugcgggauuccuugcuuuucgcgcaaggugagauuuugggcaacagcangucngugaugcuccucaauguucugggcgacacgcncacuacaaugucagugagaacaagagcgacgcucccgcuugaucaaaagagcggggaaaccacggaaucacguagacccacuugggaccgaguauugcaauuanuggucgcgcaacgagnaaugucucguaggcgcagcucaucanacugugccgauuacgucccugccauunguacacaccgnccgucguuguuuccgaugnnggugcaauacaggugaucggaccgucaccgaaaguucaccgauauugcuucaauagagnaagcaaaagucguaacaagguagcuguaggugnnccugcagcuggaucauuu ...<<<<<...{{{{>>>>>{{{{.[[[[[[...[[[..........[[[.[[[..<<....<<....<<<<...>>>>...>>.>>......{{........[[[..[[..[[...[[..{......<<<<.>>>>....<<.....<<<<<<.....>>>>>>......>>..........<<<<<.<<<<<<.>>.>>>>>>>>>.[[((((((((.....<<<<<<<<<<<<<<<......>>>>>.........................))))))))...]]....<<<<<<<.>>>>>>>...}..]]..]]]]..]]].<<<....<<<....<<<<<.<<.......>>.>>>>>>>>......>>>..<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<<<<<..>>>>>...]]]]]].........<<<....<<<..........>>>..>>>.......]]]....<<<...<.<.....>.>...>>>.....<.<..............>......>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..]]]]]]}}}}.........[[[[[.....((((...(((.......<<<<...<...<..<<....<<..<.<...........>.>..>>..>>.>...>..>>>>.................<...<<........<...<<<.......>>>.>...>>...>...<<..<...........<...<<.......>>..<......>.......>..........>....>>...........[[..(((.....>>>>>>>>>>....)))..]]........<<<<<<<<<....<<<..>.>>.....>>>>>>>>>.............<<<<<..<<...<<<<<<<<..<<<<<<<<...<<<......>>>......>>>>>>>.>.>>.......<<....>>.>>>>>>...>>>>>.>>....)))...))))...<<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>>.........<<<.<<...<..<.<<<<<........................<<<<.......>>>>.>>>>>.>..>......<<..]]>>.....>>.....>>>.]]].<<<......<<<<....>>>>....>>>..}}}}..<<<<<.<<<<<<<..<<.<<<<<<..<<.<<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<<<.....<<<.<<<<<<................................>>>.........>>>.>>>.....>>>>....<<<<<<<....>.>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>>.>>.....<<<.<<<.......<...<....><<<<<<<........>>>>>>>....>........>>>...>>>......<....<<<.<<..........>>.>>>.....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<<<<<..<<.<<<.<<<<<<..<<<<<.<...<.<<.>>.>...>.>>>>>..>>>>>>.>>>.>>..>>>>>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))((((.((((((...(((...((.....(((.(((..((....((....((((...))))...)){))......(((.......(((..((..((...((..(......((((.))))....((.....((((((.....))))))......))..........(((((.((((((.)).))))))))).(.((((.(((.....[[.[[[[[[[.(((((....))))).................(......).))).))))....)....((((((...))))))...)..))..))))..))).(((....(((....(((((.((.......)).))))))))......)))..(((.((((....))))....)))))).((.(((..........))).)).((((....))))...)))))).).....(.(((...((((.}........))).))))).)....)))....(((.....(.....).....))).....((................).....).........(.((([[......((((.....((..]])).......)))).))).)..))))))))))..{......((({{...(.((((...(((..(....((((...(................(...............).............)..)))).................(...((........(...(.(.......).).)...))...)....(..(...........(...((.......)).................)..........)....)............(....(......]]]]]]].]].....)....)........(.(((((((..(.(.......))....)))))).))......)....(.(.(((...(...((((((((...(((((((...((........))......)))))))...)).......((....)).))))))..)..)))..)...))))...))))....((((((....(...((((.........))))...).))))))......<...(((.((.........(..(........................((((.......)))).)..)............((..}})).....))...}.))))))).((.......((((....)))).....))...]]].](((((.(((((((..((...((((..((.(((((((.......(........)...........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))....((......))....)).))).....((((..(((..(..(((.(.((.(................................).).........).).)))..)..)))...(.((((((.......))))))....)..)))).....))).))).....).))))).....).)))))...)).))))).)).(...(((((((.......(.()......(((((((........)))))))....)........))).).)))......(....(((.((..........)).))).....)..)..))))......(((.(((.........))).)))......))...)))))))))).))..(.(..((.(.(((((.((..((.(((.((((((..(((((.(...(.......)...).)))))..)))))).))).))..)).)))))..).))...)..)..(((((((((....)))))))))>........ CRYO-EM STRUCTURE OF TRYPANOSOMA BRUCEI PROCYCLIC FORM 80S RIBOSOME : PARENTAL STRAIN; SSU rRNA 8ova BB 1119 2.47 RF02543 URS00029156D6_5702 37985661 0003735 0005840 5702 cccaacugcagaccguacucaucaccgcaucagguccccaagcaucgaaugcucugguacauagagaaangnacacucagggaagucggcaaanuagaugcguaaguucgcaagaagcauuggcucugagggcaaaaauugccaacucagaacugnuuacggcggggaauccaacugunuaauuaaaacauagguuugugaugcauccaagugguguaugucgcaaacugauuucugcccagugcucugugucaacgugacgagauucaccgacgcgcggguaaacggcgggaguaacuaugacucucuuaagguagcnaanugccucnucuuccaauuagagacgcgcaugaanggauuaaugngauucccucugunccgaguuncuaucuagcgaancgacagucaagggaacggacuugnagggcuaagcggngaaagaagacccunuugaguuugacnccagucuggcucugugcggcgacuuacguugcuucacuuaucgaaugaagagaccaaugguuguuuugcgcagucuucgggcugugcgccgucuaggcugacgcgugcggaacuacugcgccaaacggggugguucuccggagucuuguuucgagacaucugccagauggggaguuuggcugnggcggcauaucuguuacacgacaacgcaggnnuccuaaggcgagcucagugggaacagaaaucucacguggaacacaagcguaaaugcuugcuugauuaacgauuuccaguangaaucgagacugcgaaagcaaggccngcgauccuuugcgaagaacaggaaauaugaacaaaucauaccanangugucagaauaauuacnacagngauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuungaugucggcucuuccuaaccuagcgccgcagaagacgcuaaggguuggaunguucacccacugncagggaacgugngcuggguuuagancgucgugagacagguugguuunacccuacuuggcuggagauugcgaguaaaagauuauccgcgcaaagcggaggcaguccguuuuuuucugggucugccguuggguggcaugugcuuggcgcu ........................<<......>>......<<<<<...>>>>>........<<<<....<<<<.<<<<.<<.........<.....<<<<<.....<..>......>>>>><<.<<<<<<<<<<<...>>>>>..>>>>>>.>>..........<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<<<<....<<<<......>>>>....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>>.>>>>............<<<<<........>>>>>..<<<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<...<<<.<<<<<<....>>>>>>.>>>...<<<<<.....<<<<....<<<......<<<<<<<......>>>>>>>>>>...<.<..<...>..>>....................<<<.<..>.>>>...>>>>...>>>>>.......>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<......>>....>>>>>>>...<<...<<<<<.......>>>>>..>>.<<<....>>>.>>.........<<<<<..............<<<<.......>>>>.>>>>>..........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<<<<<<<.<......>.>>>>..>>>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>>>.......................<<<<.....>>>>...<<<...........>>>..........<..<.<.......>.>.>.... ........................((......))......((((.....))))........(.((.....(((.((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((...)))))..)))))).))..........(((((((((...((.........))...(((((((....((((.....))))......))))))).].(.(.(((..((((((..(((....((((......))))....))).))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....).)....)).))))))).)..))).)))))))..)).).........[...(.((......].)).)...(((((((..(((.((......((((.(((((...(((((.(((((((...(((.((((((.().)))))).)))....((((.....(((.....(((......(((((((......))))))))))..(..(...(.)...)..)..................((........))....)))...))))........)))))))..)))))..(((......[)).)(((((...........].)))))([((...(((((((.(.((((((.......))))))...).((][....))....))))))).(.(....(((((....{..)))))...))(((....))).))...].....((.((.(............((((.......))))))).))....)}.....)))..)))))).......(....(.((((((...((.......))...))))))...)....)........((((.((((((..(((((((.(......).))))..))).(((.(.....).))).....)))))..)...))).)......((((((....))).))).....))..))).))))))).......................((((.....))))...((.............))...............(.......)........ CRYO-EM STRUCTURE OF TRYPANOSOMA BRUCEI PROCYCLIC FORM 80S RIBOSOME : PARENTAL STRAIN; LSUb rRNA 8ova BH 119 2.47 URS00005A0173_5702 37985661 5702 ugucccucuccaaacgagaguacaugcaugggcuggcaugagcggcacgcucggggcucgaggggcaccgucccgaggcgcugaaccuugaugcuuggaauuucaugcucagggacuuu .<<<<<.<<<.......>>>.....<<<<<<<<.<<.....<<<....<.<....>.>....<<<......>>>....>>>....>>.....>>>........>>>>>...>>>>>... .(((((.(((.......))).....((((((((.((.....(((......((..))......(((......)))....)))....)).....)))........)))))...)))))... CRYO-EM STRUCTURE OF TRYPANOSOMA BRUCEI PROCYCLIC FORM 80S RIBOSOME : PARENTAL STRAIN; SrRNA-4 8ova BG 183 2.47 RF02543 URS00000EFF4F_5702 37985661 0003735 0005840 5702 gugagauugugaagggaucucgcaggcaucgugagggaaguaugggguaguacgagaggaacucccaugccgugccucugguuucuggaguuugucgaagggcaagugcuccgacgcuaucgcacggugguucucggcugaacgccucuaagccagaaaccagucccaagaccgggugcccgu <<<<<<<.........>>>>>>>.<<<<<<....<<<<.<<<<<<<<...............>>>>>>>><<<<<...<<<<....<<<<<<<<<......>>>>..>>>>>...>>>>..>>>>>.<<<<..<.<<<<...........>>>>.>..>>>>.>>>>.......>>>>>>... (.(((((.........))))).).(((((((...(((..(((((((......(....).....)))))))(((((...((((....((((((((((....)))))..)))))...))))..))))).((((....(((.............)))....))))..))).....).))))))... CRYO-EM STRUCTURE OF TRYPANOSOMA BRUCEI PROCYCLIC FORM 80S RIBOSOME : PARENTAL STRAIN; SrRNA-2 8ova BF 69 2.47 URS000029EC47_5702 37985661 5702 ucgaaucgccacuucucuuauccggugggcugcccgcccggcgcccaguaccuucauuuucacaagauc .......<<<.............<<<<<<<.>>>>>>>.>>>........................... .......(((.............(((((((.))))))).)))........................... CRYO-EM STRUCTURE OF TRYPANOSOMA BRUCEI PROCYCLIC FORM 80S RIBOSOME : PARENTAL STRAIN; SrRNA-6 8ova BE 188 2.47 URS00029156E9_5702 37985661 5702 cuguggaaaugcgaaacacuugccaggugacccauccauccucccacggugagcuuucuuuucaccauaauccacuugggccucucgacuucucgcguuacucggagcgggggcucaagauugaaaaaugcagcucacccuacguacuguugugaguucggcgcauuaaagcaaaaaccugggguguu ..<<<....>>>.....<<<..<<<<<<.......<<...<<<<...<<<<<<.......>>>>>><...<<.<<<<<<<<<<<<........<<.......>>....>>>>>>>>>>>.>.>>....><<<<...<<.....>>.>>>>.>.>>>...>>...............>>>>>>>>>... ..(((....))).....(((..(.((((.......(....(.((...((((.(.......).))))(...((.((((((((((((........((.......))....))))))))))).).))....)((((...((.....)).)))).).).)....)...............)))).))))... CRYO-EM STRUCTURE OF TRYPANOSOMA BRUCEI PROCYCLIC FORM 80S RIBOSOME : PARENTAL STRAIN; SrRNA-1 8ova BD 119 2.47 RF00001 URS000020E902_5702 37985661 0003735 0005840 5702 ggguacgaccauacuuggccgaaugcaccauaucccguccgauuugugaaguuaagcggccacaggccucguuaguacggcgaucagugauggcgcuggaacccgggguguuguacucu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((.(((...(....)...)))...))....)))))).))((((((......(((((..((....)).))))).....))))))))))))))). CRYO-EM STRUCTURE OF TRYPANOSOMA BRUCEI PROCYCLIC FORM 80S RIBOSOME : PARENTAL STRAIN; 5S rRNA 8ova BC 160 2.47 RF00002 URS00029156A2_5702 37985661 0003735 0005840 5702 aacgugncgcgauggaugacuuggcuuccuauuucguugangnacgcagcaaagugcgauaagugguaucaauuncagaaauugcccaaucuuugaacgcaaacggcgcaugggagaagcucgagccauccccgugcaugccacauuucucngugucgaa .........................................<<<<<<<<<....>>>>.....(<<<<......>>......>>>>.)...>>>....<<.....>><<<<<<<....<<<..>>>....>>>>>>>....................... .........................................((((((.[[.....))).....(((((......]]......)))).)...)))....((.....))(((((((....(((())))....)))))))....................... CRYO-EM STRUCTURE OF TRYPANOSOMA BRUCEI PROCYCLIC FORM 80S RIBOSOME : PARENTAL STRAIN; 5.8S rRNA 8ova AB 19 2.47 URS00029156E6_5702 37985661 5702 gcccggaguccgggcacca <<<<<<...>>>>>>.... ((((((...)))))).... CRYO-EM STRUCTURE OF TRYPANOSOMA BRUCEI PROCYCLIC FORM 80S RIBOSOME : PARENTAL STRAIN; E-SITE TRNA 8ove AA 1836 2.6 RF01960,RF02542,RF01959,RF00177 URS00029156E8_5702 37985661 0003735 0005840 5702 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CRYO-EM STRUCTURE OF TRYPANOSOMA BRUCEI PROCYCLIC FORM 80S RIBOSOME : TB11CS6H1 snoRNA mutant; SSU rRNA 8ove AB 19 2.6 URS00029156E6_5702 37985661 5702 gcccggaguccgggcacca <<<<<<...>>>>>>.... ((((((...)))))).... CRYO-EM STRUCTURE OF TRYPANOSOMA BRUCEI PROCYCLIC FORM 80S RIBOSOME : TB11CS6H1 snoRNA mutant; E-SITE TRNA 8ove BA 1579 2.6 RF02543 URS00029156E1_5702 37985661 0003735 0005840 5702 agaccugaguguggcaggaccacccgcuaaacuuaagcanauuacucagcggaggaaaagaaaacaaccgugauucucucagucagcggcgagcgaagagggauucaacucguugccgaaucgggucuuauaugaccucgaacuguggcauagggcuggugcaggcguggcggaauucaauugcaaagcaaacccguugcugaacauacaacccuucaugugnguauugagccaaagaaggugucagcccauuacagccacggagccuacgcgccuccucaagagaguagcacuguuugggaaugcagugucaagccggcagguauuugucugccaagguuaaauauagaguaggaagaccgauagcgaacaaguagcgugagcgaaaguuugaaaaguacuuuggaaagagagugacauagaaccugaaaucgugacaacgacaauggaaguaccuucauuucucggccagacccaaccucgccgcgcaauuuccuuccggggcuaacauccgguggguacugugcggguuucgaggucauggggugcgugagugggcggaauaaagggucggugguuguguucuuccuccuucccuguccgugcgucucgacgcuggcgauggaaauggggugcccccacccgucuugnnacncggaccaaggagunanacagacgcgcaagggaggaguauugugacaacuuuucucguacugaaagggaggugugauacacccguggcgugcgcaauuuguguuuuugcccaacaccgaccggcgugggcugcgcgcgagugugccunnuuggacccnanagguggugaacuaugccugaacaaggugaagcccggggaaaccccgguggaggccuguagcgaugcugncgugcaaaungcucguacgauuugggunucgnagcgaaagacucaucgaaccaccuaguagcugguucacgucgaaguuucccucaggauagcuggugcuuguuaagaaguauugugcgguaaagcaaaugauuagagggaccuauucucaaacuuuaaangugcaaacaacccagccuuaguuauaacaaggcuggguaauugaggcaccaagugggccuucuucgguaagcngagcaggcgaugcggaaugaaccgcuuagggauauguggcgucaaaacuugugggcucauunucgauacgugaaaaggguguugguggauauccaccggccccgaaaauggangacgcuuaagccccaugugcgugauugcccauuauuccuuuggugagggcggcuauaugugagaaaguguagcccucccgauguagacguggcgugggggugaggacgaagccgauggcgcgagccucggauggacccgccucuagugcanaunuugguuggcgunncaaagaucuaacggaauauuuuuaaaugcaacguuggauncuggagcggggaaggauuucgugccaacggcacucguacacganuuguucggucacugagcacaacguuacaccgunuuguuaggaaagaaaaggggcaacagagaaccugggaugauauuccaaaaagaauugcauguggg ......................<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<......<<.....>>....>>>>>....<<<...<<<<<..<<<<<<<......>>>>>.>>....>>>>>.<<<...<<<<<<<<<<<<<<......<<<......<<<<.......>>>>.......<<........>>......>>>.<<.......((.....>>))......>>>>>...>>>>..>>>>>.>>>..........<<<<<<<........>>>>>>>......<<<<<........>>>>>..>>>....................................<<....>>................<<<<....>>>>..................................<<<..<<<<<<.<<<<<..<<.<<<<.(<<<<<<<<<<<<<<<.....<<<.<<<<<.......>>>>>.>>>....>>>>>>....>>>>>>..>>>..............<<<<....<<<<..<<.<<..<....>..>>.>>..>>>>.>>>>....<<<<<..)>>>>>>....>>>>>>>>>>>..>>>.<<<<........>>>><<<<<<....<<<<<<<.<<<<<..<<<...<<<.........>>>...>>>...<<....>>..<<<<<...>>>>>......<...<.<.......>.>....>.....<<<.<<......>>.>>.>.....>>>>>.>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<.<<<....>>>.>>>.....>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>...<<<<<....<.<<<....>>>.><<<<<<<<<.......<<.<.<<<<<<....<<<....<<<....<<<..>>>....>>>..>.>>....>>>>>>...<<<<<<<<<<.<<<..>>>>>>>>>>>>>.>>>..>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>...<<<<......>>>>..<<<<<<<...<<<(((......<<.<<<<........<...........<<<.<<<<<<<<<..>>>>>>>>>>>>..........))).>....>>>>>>...........>>>...>>>>>>><<<<.<<<<<..........>>>>>........>>>>>>>>>....>>>>>..<.<<<<<<<<........<<<<..<<<....>>>.>>>.>.....>>>>>>>>..>.....>>>>>>..............<<<<<<<..................>>>>>>>....................<<<<<....<<.....>>..>>>>>.....<..........<<.<<<<<......>>>>.................>.>>..........<<<<.........>>....>>.>........... ......................(((((......(...[..).......)))).).........((....))...((((.......((.]...)).....))))....((((..((((..(.((((((......))))).).....))))).(((...((((.(.((((((.(...({((.......((((.......)))).......((........)).......)))[[(...)..((....}]]))....)..))))...)).)...)))).))).....)....(((((((........)))))))......(((((........)))))..)))....................................((....)).............(..((.(....).))............)......................((..((((((.(((((..((.((((.(((((((((.((((((.....(((.((((.........)))).)))....)))))).....)))))..))).).............(((....((((..((.((..(....)..)).))..)))).)))......[[[....))))))....)))))))))))..))..(((..........)))((((.(....((.((((.(((((..(((.(.(((.........)))..))))...((....))..((.((...)).))......(.....(.......)......).....(((.((......)).)).).....))))).)))).))..((.(...((((((.....((((((((((.((((...(((.(((....))).)))...).)))...(((..((.((........)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).).(((((((((......((.(.((((((....(((.....(...(.(((..))).)...)...)).)....))))))...((((((((((.((....)))))))))))).))).)))))))).)...((((.((.((.....)).)).))))....(((......)))...(((((((...((([[[...(..((.((((........(...........(((.(((((((((..))))))))))))..........]]].)....)))))))..........)))...)))))))((((.(((((...........]]].........)))))))))....))))).)(.((((((((.(......((((..(((....))).))).)...).))))))))..).....).))))..............(((((((..................)))))))....................(((((....((.....))..))))).....(......(...((.(..((......))...................).))....).....((((.........))....)).)........... CRYO-EM STRUCTURE OF TRYPANOSOMA BRUCEI PROCYCLIC FORM 80S RIBOSOME : TB11CS6H1 snoRNA mutant; LUS_alpha rRNA 8ove BB 1109 2.6 RF02543 URS00029156B3_5702 37985661 0003735 0005840 5702 caacugcagaccguacucaucaccgcaucagguccccaagcaucgaaugcucugguacauagagaaangnacacucagggaagucggcaaanuagaugcguaaguucgcaagaagcauuggcucugagggcaauugccaacucagaacugnuuacggcggggaauccaacugunuaauuaaaacauagguuugugaugcauccaagugguguaugucgcaaacugauuucugcccagugcucugaaugucaacgugacgagauucaccgacgcgcggguaaacggcgggaguaacuaugacucucuuaagguagcnaanugccucnucuuccaauuagagacgcgcaugaanggauuaaugngauucccucugunccgaguuncuaucuagcgaancgacagucaagggaacggacuugnagggcuaagcggngaaagaagacccunuugaguuugacnccagucuggcucugugcggcgacuuacguugcuucacuuaucgaaugaagagaccaaugguuguuuugcgcagucuucgggcugugcgccgucuaggcugacgcgugcggaacucugcgccaacgggguggaauucuccggagucuuguuucgagacaucugccagauggggaguuuggcugnggcggcauaucuguuacacgacaacgcaggnnuccuaaggcgagcucagugggaucucacguggaacacaagcguaaaugcuugcuugauuaacgauuuccaguangaaucgagacugcgaaagcaaggccngcgauccuuugcgaagaacaggaaauaugaacaaaucauaccanangugucagaauaauuacnacagngauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuungaugucggcucuuccuaaccuagcgccgcagaagacgcuaaggguuggaunguucacccacugncagggaacgugngcuggguuuagancgucgugagacagguugguuunacccuacuuggcuggagauugcgaguaaaagauuauccgcgcaaagcggaggcaguccguuuuuuucugggucugccguuggguggcaugugcuuggcgcu ......................<<......>>......<<<<<...>>>>>........<<<<....<<<<.<<<<.<<.........<.....<<<<<.....<..>......>>>>><<.<<<<<<<<<<<>>>>>..>>>>>>.>>..........<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<..<<<....<<<<......>>>>....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>>.>>>>............<<<<<........>>>>>..<<<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<...<<<.<<<<<<....>>>>>>.>>>...<<<<<.....<<<<....<<<......<<<<<<<......>>>>>>>>>>.....<..<...>..>...................<<<.<<..>>.>>>...>>>>...>>>>>.......>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<..>>>>>.....<<......>>....>>>>>>>...<<...<<<<<.......>>>>>..>>.<<<....>>>.>>.........<<<<<..............<<<<.......>>>>.>>>>>..........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<<<<<<<.<......>.>>>>..>>>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>>>.......................<<<<.....>>>>...<<<...........>>>..........<..<.<.......>.>.>.... ......................((......))......((((.....))))........(.((.....(((.((((.((..(....(.......(((((....(.[..).....)))))((.((((((((((()))))..)))))).))..........(((((((((...((.........))...(((((((....((((.....))))......))))))).].(.(.(((..((((((.(...((....((((......))))....)).)))))..)))))(.(.(.........).).)........((..........(((((.......)))))..)..)....).)....)).))))))).)..))).)))))))..)).).........[...(.((......].)).)...(((((((..(((.((......((((.(((((...(((((.(((((((...(((.(((.((....)).))).)))....((((.....(((.....(((......(((((.(......).))))))))..(.....((.)).....)................(((..(..)..)))....)))...))))........)))))))..)))))..(((......[)).)(((((...........].)))))([((...(((((((.(.(((((())))))...).((][....))....))))))).(.(....(((((....{..)))))...))(((....))).))...].....((.((.(............((.(.......).))))).))....)}.....)))..)))))).......(....(.((((((...((.......))...))))))...)....)........((((.((((((..(((((((.(......).))))..))).(((.(.....).))).....)))))..)...))).)......((((((....))).))).....))..))).))))))).......................((((.....))))...((.............)).........(...(.(.......).)...).. CRYO-EM STRUCTURE OF TRYPANOSOMA BRUCEI PROCYCLIC FORM 80S RIBOSOME : TB11CS6H1 snoRNA mutant; LSUb rRNA 8ove BC 160 2.6 RF00002 URS00029156A2_5702 37985661 0003735 0005840 5702 aacgugncgcgauggaugacuuggcuuccuauuucguugangnacgcagcaaagugcgauaagugguaucaauuncagaaucauugcccaaucuuugaacgcaaacggcgcaugggagaagcucgagccauccccgugcaugccacauuucucngugucg .........................................<<<<<<<<<....>>>>.....(<<<<......>>........>>>>.)...>>>....<<.....>><<<<<<<....<<<..>>>....>>>>>>>..................... .........................................((((((.[[.....))).....(((((......]]........)))).)...)))....((.....))(((((((....(((())))....)))))))..................... CRYO-EM STRUCTURE OF TRYPANOSOMA BRUCEI PROCYCLIC FORM 80S RIBOSOME : TB11CS6H1 snoRNA mutant; 5.8S rRNA 8ove BD 119 2.6 RF00001 URS000020E902_5702 37985661 0003735 0005840 5702 ggguacgaccauacuuggccgaaugcaccauaucccguccgauuugugaaguuaagcggccacaggccucguuaguacggcgaucagugauggcgcuggaacccgggguguuguacucu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((.(((...(....)...)))...))....)))))).))((((((......(((((..((....)).))))).....))))))))))))))). CRYO-EM STRUCTURE OF TRYPANOSOMA BRUCEI PROCYCLIC FORM 80S RIBOSOME : TB11CS6H1 snoRNA mutant; 5S rRNA 8ove BE 166 2.6 URS00029156E9_5702 37985661 5702 guggaaaugcgcuugccaggugacccauccauccucccacggugagcuuucuuuucaccauaauccaccuugggccucucgacgcguuacucggagcgggggcucaagauugaaaaaugcagcacugucugugaguucggcgcauuaaagcaaaaaccuggggugu <<<....>>>..<..<<<<<<.......<<...<<<.<<.<<<<<<.......>>>>>><...<<.<.<<<<<<<<<<<...<<.......>>....>>>>>>>>>>>.>.>>....><<<<..>>>>.>>.>>>...>>...............>>>>>>.>... (((....)))...(.(.((((.......(....(.(..(.((((.(.......).))))(...((.(..((((((((((...((.......))....))))))))))..).))....).(((..)))..)..).)....)...............)))).)).... CRYO-EM STRUCTURE OF TRYPANOSOMA BRUCEI PROCYCLIC FORM 80S RIBOSOME : TB11CS6H1 snoRNA mutant; SrRNA 1 8ove BF 69 2.6 URS000029EC47_5702 37985661 5702 ucgaaucgccacuucucuuauccggugggcugcccgcccggcgcccaguaccuucauuuucacaagauc .......<<<.............<<<<<<<.>>>>>>>.>>>........................... .......(((.............(((((((.))))))).)))........................... CRYO-EM STRUCTURE OF TRYPANOSOMA BRUCEI PROCYCLIC FORM 80S RIBOSOME : TB11CS6H1 snoRNA mutant; SrRNA 6 8ove BG 183 2.6 RF02543 URS00000EFF4F_5702 37985661 0003735 0005840 5702 gugagauugugaagggaucucgcaggcaucgugagggaaguaugggguaguacgagaggaacucccaugccgugccucugguuucuggaguuugucgaagggcaagugcuccgacgcuaucgcacggugguucucggcugaacgccucuaagccagaaaccagucccaagaccgggugcccgu <<<<<<<.........>>>>>>>.<<<<<<....<<<<.<<<<<<<<...............>>>>>>>><<<<<...<<<<....<<<<<<<<<......>>>>..>>>>>...>>>>..>>>>>.<<<<..<.<<<<...........>>>>.>..>>>>.>>>>.......>>>>>>... (.(((((.........))))).).(((((((...(((..(((((((......(....).....)))))))(((((...((((....((((((((((....)))))..)))))...))))..))))).((((....(((.............)))....))))..))).....).))))))... CRYO-EM STRUCTURE OF TRYPANOSOMA BRUCEI PROCYCLIC FORM 80S RIBOSOME : TB11CS6H1 snoRNA mutant; SrRNA 2 8ove BH 118 2.6 URS00005A0173_5702 37985661 5702 ugucccucuccaaacgagaguacaugcaugggcuggcaugagcggcacgcuccauggggcucgaggggcaccgucccgaggcgcugaaccuugaugcuuggaaucaugcucagggacu .<<<<<.<<<.......>>>.....<<<<<<<<.<<.....<<<....<.<<<...>>>.>....<<<......>>>....>>>....>>.....>>>......>>>>>...>>>>>. .(((((.(((.......))).....((((((((.((.....(((......(((...)))......(((......)))....)))....)).....)))......)))))...))))). CRYO-EM STRUCTURE OF TRYPANOSOMA BRUCEI PROCYCLIC FORM 80S RIBOSOME : TB11CS6H1 snoRNA mutant; SrRNA 4 8ovj 1 1611 2.4 RF02543 38722744 0003735 0005840 347515 cagaccugaguguggcaggacuacccgccgaacuuaagcauauuacucagcggaggaaaagaaaacaaccgugauucucucagugagcggcgagcgaagagggaacgaacucguugccgaaucgggucuuacaaggccuugaguuguggcacgugugguuggugcaggaguggcgaaauucaagcgaaaagcaaacccguugcugaauacaacccuucaugugnguauugagccaaagaagguguuagcccauugagccauaaaccugagcgccucaugaacaagcgnguagcacuguuugggaaugcagugucaaguggcagguauuugucugccaaaguuaaauacagaguaggaagaccgauagcgaacaaguagcgugagcgaanguuugaaaagcacuuuggaaagagagugaaauagaaccugaagucgugacaaagacaauggaaguaccuccauuucaacggccagaaccagcccuacugcauuauccugucggggaucaaaauccggcgggcaacgaagugcaagaaugggucuuggugaaaugagcggaguauuugugcugcgcacggcggccgcacgcacugguuucuucuccgugaugcuccauguuggcgauggaaauggggugcccccacccgucuugnnacncggaccaaggagunanacagacgcgcaagggaggagauaugccaguacuucucucguacugaaagggagaugcaaaaugcaucuguggugugcacacgucaaauccguuugauuugcccaacaccgaccggcccuccguggguugcguuggagugugccngnuuggacccnanagguggugaacuaugccugaacaaggugaagcccggggaaacccagguggaggccuguagcgaugcugncgugcaaaucgcucguaugauuugggunucgnagcgaaagacucaucgaaccaccuaguagcugguucacaucgaaguuuccnucaggauagcuggugcuaguagaaguauugugcgguaaagcaaaugauuagaggcgaccuauucucaaacuuuaaangugcaaacaaaccggccuuagccaacugcaaggccggaaagaaaagaauuagaggcaccaagugggccuucuucgguaagcngagcaggcgaugcggaaugaaccgcuuagggauauguggcgucaaaacuuaugggcucauucucgauacgugaaaaggguugguggauccaccggccccgaaaauggangacgcuuaagcccaauuagugauugcccauuauuccuuugguaagggcggaaacaaaggagaaaguguagcccuuccgauguagauguggccuggagguuaggacgaagcuuauggcgugagccuaagauggaccggccucuagugcanaunuugguuggcgunncaaagaucuaacggagauauacucaacaugcaacguuggauacuggagcggggaaggauuucgugccaacggcacucguacacganuuguucggaaacugagcacaacguuauaucgunuuguuaggaaagugaaggaacugaaaaggggcaacagagaaccugggauuauauuccaaaaagaaauugcauguggg .......................<<<<<......<......>.......>>>>.>.........<<....>>..<<<<<<......<<.....>>....>>>>>>...<<<...<<<<<..<<<<<<<......>>>>>.>>....>>>>>..<<<<...<<<<<<<<.<<<<<......<<<......<<<<.......>>>>.....<<........>>......>>>.<<.......((.....>>)).....>>>>>...>>>..>>>>>.>>>>............<<<<<<<........>>>>>>>.....<<<<<........>>>>>..>>>....................................<<....>>................<<<<....>>>>..................................<<<..<<<<<<.<<<<<...<<.<<<<.<<<<<<<<....<<<<<..<<<<<<<<<........>>>>>>>>>.....>>.>>>......>>>>..>>>>........<<<<<.....<.<<<<.<<.<<<<.>>>>...>>.>.>>>..>..>>>>>.....<<<<...>>>>>>....>>>>>>>>>>>..>>>.<<<<........>>>><<<<<<....<<<<<<<.<<<<<..<<<<..<<.<........>>>..>>>>...<<....>>..<<<<<.....>>>>>...<<<<<...<<.<<<<<<....>>>>>>.>>....>>>>><<<<<<<<<.....>>>>>>.>>>...>>>>>.>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<.<<<....>>>.>>>.....>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>...<<<<<....<.<<<....>>>.><<<<<<<<<.....<<...<<<<<<....<<<....<<<..<.<<<...>>>.>..>>>..>.>>....>>>>>>.....<<<<<<<<.<<.....>>>>>>>>>>...........>>...>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>...<<<<......>>>>..<<<<<<<...<<<(((......<..<<<<........<...........<<<<<<<<<<..>>>>>>>>>>...........))).>....>>>>.>.........>>>...>>>>>>><<<<.<<<<<..........>>>>.........>>>>>>>>>....>>>>>..<.<<<<<<<<........<<<<..<<<....>>>.>>>.>.....>>>>>>>>..>.....>>>>>>..............<<<<<<<....................>>>>>>>....................<<<<<....<<.....>>..>>>>>....<<..........<<.<<<<<......>>>>...............<<...>>......>.>>..........<<<<.........>>....>>.>>........... .......................(((((......(...[..).......)))).).........((....))...((((.......((.]...)).....))))....((((..((((..((((((((......))))).))....)))))...(((...((((((((.(((((....({((.......((((.......)))).....((........)).......)))[[(...)..((....}]])).....)))))...)))..))))).)))........)....(((((((........))))))).....(((((........)))))..)))....................................((....)).............(..((.(....).))............)......................((..((((((.((((((..((.((((.((((((((....((.((..(((((.((..........)).))))).....))..))......))))..))))........(((((.....(.((((..(.((((.))))...)..).)))..)..))))).....[[[[...))))))..).)))))))))))..))..(((..........)))((((.(..(.(((((.(.(((((..(((...((.((......))))...)))...((....))..(((((.....)))))...(((((...((.(((((......))))).))....)))))(((((((((.....)))))).)))...))))).).)))))..((.(...((((((.....((((((((((.((((...(((.(((....))).)))...).)))...(((..((.((........)))).)))..).))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).).((((((((.....((.(.(.((((.....((....(((..(.(((...))).)..)))..))......)))).).....(((.((((.((.....)))))).)))..........)))...))))))).)...((((.((.((.....)).)).))))....(((......)))...((((((....((([[[...(..(..((((........(...........(((((((.((..)).)))))))...........]]].)....)))).))........)))....))))))((((.((((((.........]]]]...).....)))))))))....))))).)(.((((((((.(......((((..(((....))).))).)...).))))))))..).....).))))..............(((((((....................)))))))....................(((((....((.....))..)))))....((......(...((.(.(((......))).................(...).......).))....).....((((.........))....)).))........... CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME : PARENTAL STRAIN; LSUa_rRNA_chain_1 8ovj 3 156 2.4 38722744 347515 gugguaangcggccagguaacaaaucaauccucccacggugagcuuucuuuucaccauaauccaccuugggccuuuuuacucucgcguuguucggagcgggggcucaagauugaaaaaugcauugugaguucugcgcuaaagcaaaaaccuggggu <<<....>>>..<<<<<<.......<<...<<<.<<.<<<<<<.......>>>>>><...<<.<.<<<<<<<<<<<.......<<.......>>....>>>>>>>>>>>.>.>>....>....>>.>>>...>>.............>>>>>>... (((....)))..((((((.......((...(((.((.((((((.......))))))(...((.(.(((((((((((.......((.......))....))))))))))).).))....)....)).)))...)).............))))))... CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME : PARENTAL STRAIN; SR1_chain_3 8ovj 4 183 2.4 RF02543 38722744 0003735 0005840 347515 gugggauugugaagggaucucgcagguaucgugagggaaguaugggguaguacgagaggaacucccaugccgunccucuaguuucugggguuugucgaacggcaagugccccgaagccaucgcacggugguucucggcugaacgccucuaagccagaagccaaucccaagaccagaugcccac <<<<<<<.........>>>>>>>.<<<<<<....<<<<.<<<<<<<<...............>>>>>>>><<<<<...<.<<....<<<<<<<<<......>>>>..>>>>>...>>.>..>>>>>.<<<<..<.<<<<...........>>>>.>..>>>>.>>>>.......>>>>>>... (((.(((.........))).))).(((((((...(((..(((((((......(....).....)))))))(((((...(.((....((((((((((....)))))..)))))...)).)..))))).((((....(((.............)))....))))..))).....).))))))... CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME : PARENTAL STRAIN; SR2_chain_4 8ovj 5 115 2.4 38722744 347515 uacgucccucuccaaacgagagaacaugcaugggcuggcaugagcggcaugcuucccgguggggcucgcgucccgaggcgcugaaccuugaggccugaaacaugcucagggacac ...<<<<<<<<<.......>>>>....<<<<<<<<.<<.....<<<................<<..<..>..>>....>>>....>>.....>>>.....>>>>>...>>>>>.. ...(((((((((.......))))....((((((((.((.....(((.............(..((..(..)..))..).)))....)).....))).....)))))...))))).. CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME : PARENTAL STRAIN; SR4_chain_5 8ovj 6 71 2.4 38722744 347515 aucgaaucgccaccuacaagacuggagcuugcucccucgaaggcgccaaguauauucaugaucacaagaca ......<.<<<............<<<<<..>>>>>......>>>........................>.. ........(((............(((((..)))))(..)..)))........................... CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME : PARENTAL STRAIN; SR6_chain_6 8ovj 7 164 2.4 RF00002 38722744 0003735 0005840 347515 aacgugncgcgauggaugacuuggcuuccuauuucguugaagnacgcaguaaagugcgauaagugguaucaauuncagaacauucaauuaccgaaucuuugaacgcaaacggcgcaugggagaagcucgugucauccccgugcaugccauauucucngugucga .........................................<<<<<<.((.....>>>.....<<<<<......))............>>>>.>...>>>....<<.....>><<<<<<<....<<....>>....>>>>>>>..................... .........................................((((((.[[.....))).....(((((......]]............)))).)...)))....((.....))(((((((....((.().))....)))))))..................... CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME : PARENTAL STRAIN; 5.8S_rRNA_chain_7 8ovj 8 119 2.4 RF00001 38722744 0003735 0005840 347515 gaguacgaccacacuugagugaaaacaccauaucccguccgauuugugaaguuaagcacucacaggcucaguuaguacugaggucagugaugacucgggaacccugagugccguacucc <<<<<<<......<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<......<<<<<..<<....>>.>>>>>.....>>>>>>..>>>>>>>. (((((((.(....((((((((.....((((((...(....)...))))..))....)))))).))((((((......(((((..((....)).))))).....))))))).))))))). CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME : PARENTAL STRAIN; 5S_rRNA_chain_8 8ovj S1 1755 2.4 RF01960,RF02542,RF01959,RF00177 38722744 0003735 0005840 347515 gaucuggnugauucugcnaguagucauangcuuguuunaaggacuuagccaugcaugccucagaaucacugcagcaggaaucugcgcauggcucnuuaaaucagacguaaucugccgcaaaaaucuugcggcaaaauuggauaacuuggcgaaacgccaagcuaauacaugaaccaaccgggugucuccgagacgcccagcgaaugaaugacaguaaaaccaaugccgcaguaacacccagcaguguugacucaauucauucgcgaaagccggcuuccggcgucuuuugacgaacaacugcccuaucagcuggugauggccguguaguggacugccauggcguugacgggagcgggggauuaggguucgauuccggagagggagccugagaaauagcuaccacuucuacggagggcagcaggcgcgcnaauugcccaaugucaaaacaaaacgaugaggcngcgaaaagaaauagaguuuuucaaugggggauauuuaaacccauccaauaucgaguaacaauuggangacaagucuggugccagcacccgcgguaauuccagcuccaaaagcguauauuaaugcugungcuguunaaggguucguaguugaacugugggcucccuugcagcccgugaaagaaaaaacacgggagugggucgcaugucaugcaugccguccgugauuuuuuacugugacuaaagaagcgugacuaaagcagucaugacuugaauuagaaagcaugggauaacaaaggagcuuuuuaaagguuggagauuauggagcugugcgacaaaugcuuucccaucucggugugggguuuacggccucuaggaaugaaggaggguaguucgggggagaacguacuggggcgucagaggugaaauucuuagaccgcaccaagacgaacuacagcgaaggcauucuucaaggauaccuuccucaaucaagaaccaaaguguggagaucgaagaugauuagaaaccauuguaguccacacugcaaacgaugacacccaugaauuggggauaucuucacguuuucuguuuuuuacgcgaaagcuuugagguuacagucucaggggggaguacguucgcaanagugaaacuuaaagaaauugacggaauggcaccacaagacguggagcgugcgguuuaauuugacnnaacacngggaacuuuaccagauccggacaggaugaggauugacagauugaguguucuuucucgauucccugaauggngnugcauggccgcuuauggucggugnagugauuuguuugguugauuccgucaacggacgagauccaagcugcccaguagaauucagaauugcccauaggauagcgcauucggaauucuucucugcgggauuccuuuguagcacaaggugaaauuuugggcaacagcangucngugaugcuccucaauguucugggcgacacgcnnacuacaaugucanugagaacaagaacuacuugaucaaaagaguggggaaaccccggaaucacauagacccacuugggaccgaggauugcaauuanuggucgcgcaacgagnaaugucucguaggcgcagcucaucanacugugccgauuacgucccugccauuuguacacaccgccngucguuguuuccgaugauggugcaauacaggugaucggacagggcccgaaaguucaccgauauuunuucaauagagnaagcaaaagucguaacaagguagcuguaggggnnccugcagcugggacauuuu 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...((((..[..[[..))))((((.((((((...(((...((.....(((.(((..((....((....((((.))))...)){))......(((.......(((..((..((...((.((.....((((.))))....(.....((((((.....))))))......)...........((((.((((.)))).)))).((((((((((......[.[[.[..[(...)................(......).))))))))))....(((((...)))))...)).))..))))..))).(.(....(((....(((((.((.......)).))))))))......).)..(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}........))).))))).)....)))....((.....)).....((((............))).....).........((((([[....(.(.((.....((..]])).......)).)))))))..))))))))))..{......((({{...(.((((...(((..(....(.............)............(........(.......((((.......))))..)......)...((.(((((.......((..((.......)).(((..))).....))......)))))...))........(.((..(.((...]..].]].]....)).)..))..............(.....(....)......).......)...)....(.(.(((..((...(((((.((...(((.(((...(..........)......))).)))...)).......((....))..)))))..)).)))..)...))))...))))....((((((....(...((((.........))))...).))))))......<...(((.((............(...........).............((..}})).....))...}.))))))).(((......((((....))))....)))...]]..]((((..(.(((((..((..(((((..((.(((((((.......(........).........(.(((((.(....((((......(..((.(((........))).))....)..))))...((..(....(.((((((....(((.(.(((....)))....((......)).....).))).....((((.((((.....(((((((.(.((.................)).).))))))).....))))..(.((((........))))....)..)))).....))).))).....)..).)).....).))))))..)).))))).)).(...(((((((.......(..(..(..............)..)...)........))).).)))......(....((..................)).....)..)..))))).....(((((((.........)))))))......))...))))).).)).))..(.(..((.(.((((((((..((.(((.(.((((..(((((.(...(.(...).)...).)))))..)))).).))).))..))))))))..).))...)..)..(((((((((....)))))))))>......... CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME : PARENTAL STRAIN; SSU_rRNA_chain_S1 8ovj S4 20 2.4 38722744 347515 gcgcgggaguccgcgcacca <<<<<......>>>>>.... ((((((....)))))).... CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME : PARENTAL STRAIN; E-site_tRNA_chain_S4 8ovj 2 1105 2.4 RF02543 38722744 0003735 0005840 347515 ccaacugcagaccguacucaucaccgcaucagguccccaagcauagaaugcucngguacauagagaaangnacacucagggaagucggcaaanuagaugcguaaguucgcaagaagcauuggcucugagggcaaaaauugccaacucagaacugnuuacggcggggaauccaacugunuaauuaaaacauagguuugugaugcauccaagugguguauaucgcaaacugauuucugccnagugcucugaaugucaacgugacgagauucaccgacgcgcggguaaacggcgggaguaacuaugacucucuuaagguagcnaanugccucnucuuccaauuagagacgcgcaugaanggauuaaugngnuucccucugunccgaguuncuaucuagcgaancgacagucaagggaacggacuugnagggcuaagcggngaaagaagacccunuugaguuugacnccagucuggcucugugcggcgacauccguugcuucacuuaucgaaugaagagaccaauggguugcguagucuucgggcuaugcaccgucuagguuguggguacccaaccgugcuguaaacugaaccaacgggaguuccggagucuuguuucgagacaucugccagauggggaguuuggcugnggcggcauaucuguuacacgacaacgcaggnnuccuaaggcgagcucagugggaacagaucucacguagaacacaagcguaaaagcuugcuugauuaacgauuuccaguangaaucgagacugcgaaagcaaggccngcgauccuuugcgaagaauaggaaauaugaacaaaucauaccanangugucagaauaauuacnacagngauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuungaugucggnucuuccuaaccuagcgccgcagaagacgcuaaggguuggaunnuucacccacugncagggaacgugngcuggguuuagancgucgugagacagguugguuunacccuacuuagcuggaaauugcgagaaaaagauuauccgugcaaagcggacguggcgagcgguggguaguacaugguacgcucaucacc .......................<<......>>......<<<<<...>>>>>........<<<<....<<<<.<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<...>>>>>..>>>>>>.>>..........<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<....<<<<......>>>>....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>>.>>>>............<<<<<........>>>>>..<<<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<...<<<.<<<<<<....>>>>>>.>>>...<<<<<.....<<<<....<<...<<<<<<<<<..>>>>>>>>>.>>.....<<<............>>>...................<<<<...>>>>..>>>>...>>>>>.......>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.....>>>>>>.....<<......>>....>>>>>>>...<<...<<<<<.......>>>>>..>>.<<<....>>>.>>.........<<<<<..............<<<<.......>>>>.>>>>>..........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<<<<<<<.<......>.>>>>..>>>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>>>.......................<<<<.....>>>>.<<<.>>>.<.<<<<<<<.<<<<...>>>>>>>>>>>.>. .......................((......))......((((.....))))........(.((.....(((.((.(.((..(....(.......(((((....(.[..).....)))))((.((((((((.((...)).))..)))))).))..........(((((((((...((.........))...(((((((....((((.....))))......))))))).].(.(.(((..((((((.....((....(((........)))....))..))))..)))))(.(.(.........).).)........((..........(((((.......)))))..)..)....).)....)).))))))).)..))).).)))))..)).).........[..((.((......].)).))..(((((((..(((.((......((((.(((((...(((((.(((((((...(((.((((((....)))))).)))...(((((.....((((....(....((((((((....))))))))..)..(..(((............)))..)................(((.(.).)))..))))...))))).......)))))))..)))))..(((......[)).)(((.(...........].).)))([((...(((((((.(.((((((.....))))))...).((][..[.))....))))))).(.(....(((((....{..)))))...))(((....))).)).].].....((.((.(............((((.......))))))).))....)}.....)))..)))))).......(....(.((((((...((.......))...))))))...)....)........((((.((((((..(((((((.(......).))))..)))..((.(.....).))......)))))..)...))).)......((((((....))).))).....))..))).)))))))........................(((.....)))..((...)).(.(((((((.((((...))))))))))).). CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME : PARENTAL STRAIN; LSUb_rRNA_chain_2 8oz0 W 1716 3.5 RF01960,RF02542,RF01959,RF00177 URS00029156DC_9606 38287194 0003735 0005840 9606 uaccugguugauccugccaguagcaunugcuugucucaaagauuaagccaugcaugucugaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuauggunccuunggucgcucgccuacuuggauaacugugguanuucuagngcuaauanaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgccccccguggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcnaauuacccacucccgacccgggganguagugangaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauancguauauuaaaguugcugcaguunaaaagcucguaguungaucuugggagcggccccgccccucucggcggcccgaagcguuuacuuugaaaaaanuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagancgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccacnaggaguggagccugcggcuuaauuugacncaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauucngauaacgaacgagacucuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuucuuaagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauunagucccugcccuuuguacacaccgnccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccgggggcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucgnancaagguuuccguaggugnnccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<...<....<.....<<..........>>....>.>.......<<........<<<.<....<<...<.<<<<...........<<.....<<.<<.......>>.>>......>>.........<<<<...<<<<........>>>>...>>>><<..<<<<<.............>>>>>......>>....<<<..<<<......>>>.>>>..>>>>.>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....<..<<<<<<............>>.>>>>...>......<<..<...........>..>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<.....<<..........>>.<<.............>>...<<<<<<.<.......<<...<.......>.<<<<.......>>>>...>>......>.>>>..>>>........<.<<.<<<..<<...............>>..>>>.>>.>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<........>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<...<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<......<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<......>>...<<<......>>>...>>.>>>....<<<.......<<<<...<<<<<<<<<<<.......>>>>.>>>>.....>>>...>>>.>......<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.......>>>>>...>>.>>>>.>>>.....<<..<<........<.......<<<.<<<<....>>>>.>>>....>.........>>..>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>.>>>>>.>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<.......................>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((........(.....((..........))....).........(((.......(((.(.(..((.....((.....((..[...((.....(...............)......))......)).((((...((((...(..).))))...))))((..(((((...((.....)).)))))......))..].(((..(((......))).)))....)).....))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.....))).))))).)...)).).....(..((((((............).)))))...)....(.((..(...........)..))......)..((((([[....(.((((.....((..]])).......))))))))))..)))))).)))..[......(.([[...(.(.((...(((..(.....((...(..)...)).(...............)...((((((.(.......((..((.......)).(((.......)))....))......).)))..)))........(.((.(.(..((...............))..).).)).)....)....(((..(...(...((((..((..((((((((...((........))......))))))))..)).......((....))...))))..)...)...))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.((.(......).)))))))).)..)))...((..]]))...))...].))))).).(((......((((....))))....)))...]]].](((....(.((.(..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((.........((...(((((((((((.......)))).)))).....)))...)).........(((((.....)))))........)))....))).))).....).))))).....).)))))...)).)))).))).(...((..((........(.......(((.((((....)))).)))....).........))..))......(.......(((..........))).......)..)..))))).....((((((((.......))))))))......))...)..)).)..).))..(.(..((.(..((((.((..(.((((((((.(((..((((.((...(((((.......................)))))...)).))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}........ Structure of a human 48S translation initiation complex with eIF4F and eIF4A; 18S rRNA 8oz0 y 75 3.5 RF00005 URS0000326EAC_9606 38287194 0030533 0006412 9606 agcagaguggcgcagcggaagcgugcugggcccauaacccagaggucgauggaucgaaaccauccucugcuacca <<<<<<...<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>.>>>>>>.... .((((((...(((.......)))..(((((.......))))).....(((((.......)))))))))))..... Structure of a human 48S translation initiation complex with eIF4F and eIF4A; tRNAiMet 8oz0 z 50 3.5 38287194 9606 ccgcagucagauccuagcgucgaguugaugcuguccgauaaaaaaaaaaa .................................................. .................................................. Structure of a human 48S translation initiation complex with eIF4F and eIF4A; mRNA 8p03 1 75 3.04 RF00005 URS0000326EAC_9986 38244546 0030533 0006412 9986 agcagaguggcgcagcggaagcgugcugggcccaunacccagaggucgauggaucgaaaccauccucugcuacca <<<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... .((((((..((((....[..)))).(((((.......))))).....(((((..]....)))))))))))..... 48S late-stage initiation complex with m6A mRNA; initiator methionylated tRNA 8p03 2 1743 3.04 RF01960,RF02542,RF01959,RF00177 URS0001A16A63_9986 38244546 0003735 0005840 9986 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcuacuuggauaacugugguaauucuagagcuaauacaugccgacggcgcugacucccuuugugugggaugcgugcauuuaucagaucaaaaccaacccggucggcggcuuuggugacucuagauaaccucgggccgaucgcagcccuccguggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggucgcagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuuguggaggguuccccgccccuugccucucggcgccggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacncaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauucugugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagaugucggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggcccgccggggugcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<...[[[[>>>>>[[[.((((((.....{{.........[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[......{{....[[[........<<.....<<.<<<.....>>>.>>......>>.........<<<...<<.<......>.>>...>>>.[[..(((((......<<<<<<<<<<<.....>>>....<......>..)))))......]]...<<<<.<<<......>>>.>>>>....]]]...}}....]]].<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<<...>>>>..>>>......}}.......<<<<<..<<.<<<....>>>.>>...>>.>>>......<<..<...........>..>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..)))))).]]]............{{.......{{...[[[.[[....<<<<.<<...>>>>>>......<...<....<<..>>...>.>...<<<<<<.<.......<<...<.......>.<<<<.......>>>>...>>......>.>>>..>>>.......[[....(((((((.....>>>>>>>>..)))))))...]]....]]....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<<....>>>>>>>>>>>.>..>>>...<<..}}>>...>>.....>>>.....<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<......<<<<<<.......<<.<<<........>>>.>>.....>>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<....<...<.<<<....>>>>...>....>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>>.....>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<.<<<<<<<<..>>>>>>>.>...>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((..((....((....((..........))...)){))......(((.......(((.(.(..((....(((....{...((.....((.(((.....))).))......)).........(((...((.(......).))...))).((..(((((.....[[[[[[[[[(.(.....).)....(......)..)))))......)).(}((((.(((......))).)))))...)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)...)).).....((((...((.(((....))).)).....))))....(.((..(...........)..))......)..((((([[....(.((((.....((..]])).......))))))))))..)))))).)))..{......(.({{...(.(.((...(((..(....(.((.((...)))).).....((.........(())......))..((((((.(.......((..((.......)).(((.......)))....))......).)))..))).......((.(..(.((((......]]]]]]]]]..)))).)..))..)..)....(((..(...(...((((..(((.((((((((...((........))......)))))))).))).......((....))...))))..)...)...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..(.((((((.((((......)))))))))).)..)))...((..}}))...))...}.))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((.(.....(..(..(((........)))..)....).).)))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((...(...((((..((((..(.(...(.(((....))))...).)..))))..))))..).....(((((.....)))))........)))....))).))).....).))))).....))))))...)).)))).))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(...(((.((....(((((((..(((..((((.((...((((((((((.(((..))).))).).).)))))...)).))))..)))..)))))))...)).)))....).))...)..)..(((((((((....)))))))))>........ 48S late-stage initiation complex with m6A mRNA; 18S ribosomal RNA 8p09 1 75 3.3 RF00005 URS0000326EAC_9986 38244546 0030533 0006412 9986 agcagaguggcgcagcggaagcgugcugggcccaunacccagaggucgauggaucgaaaccauccucugcuacca <<<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... .((((((..((((....[..)))).(((((.......))))).....(((((..]....)))))))))))..... 48S late-stage initiation complex with non methylated mRNA; initiator methionylated tRNA 8p09 2 1741 3.3 RF01960,RF02542,RF01959,RF00177 38244546 0003735 0005840 9986 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcuacuuggauaacugugguaauucuagagcuaauacaugccgacggcgcugacucccuuugugugggaugcgugcauuuaucagaucaaaaccaacccggucgcggcuuuggugacucuagauaaccucgggccgaucgcagcccuccguggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggucgcagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuuguggaggguuccccgccccuugccucucggcgccggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacncaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauucugugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagaugucggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggcccgccggggucccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<...[[[[>>>>>[[[.((((((.....{{.........[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[......{{....[[[........<<.....<<.<<<.....>>>.>>......>>.........<<<...<<.<......>.>>...>>>.[[..(((((.....<<<<<<<<<<<<....>>>....<......>..)))))......]]...<<<<.<<<......>>>.>>>>....]]]...}}....]]].<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<<...>>>>..>>>......}}.......<<<<<<.<<.<<<....>>>.>>..>>>.>>>......<<..<...........>..>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..)))))).]]]............{{.......{{...[[[.[[....<<<<.<<<.>>>>>>>.....<<.<......<<..>>....>>>..<<<<<<.<.......<<...<.......>.<<<<.......>>>>...>>......>.>>>..>>>.......[[....(((((((.....>>>>>>>>>.)))))))...]]....]]....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<<....>>>>>>>>>>>.>..>>>...<<..}}>>...>>.....>>>.....<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<......<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<......>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<....<..<..<<......>>>...>....>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>......>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<.<<<<<<<<.>>>>>>>>....>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((..((....((....((..........))...)){))......(((.......(((.(.(..((....(((....{...((.....((.(((.....))).))......)).........(((...((.(......).))...))).((..(((((.....[[[[[[[[[(.(....).)....(......)..)))))......)).(}((((.(((......))).)))))...)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)...)).).....(((.((.((.(((....))).))..))..)))....(.((..(...........)..))......)..((((([[....(.((((.....((..]])).......))))))))))..)))))).)))..{......(.({{...(.(.((...(((..(....(.((.((...)))).).....((.(.......(..).....)))..((((((.(.......((..((.......)).(((.......)))....))......).)))..))).......((.(..(.(.(((.....]]]]]]]]].))).).)..))..)..)....(((..(...(...((((..((..((((((((...((........))......))))))))..)).......((....))...))))..)...)...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..(.((((((.((((......)))))))))).)..)))...((..}}))...))...}.))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((.(.....(..((.(((........))).))....).).)))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((...(...((((..((((..(.(...(.(((....))))...).)..))))..))))..).....(((((.....)))))........)))....))).))).....).))))).....))))))...)).)))).))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(...(((.((..(.((((((((.(((..((((.((...((((((((((.(((.))).))).).).)))))...)).))))..))).)))))))))..)).)))....).))...)..)..(((((((((....)))))))))>........ 48S late-stage initiation complex with non methylated mRNA; 18S ribosomal RNA 8p0g V 14 3.17 11569 agagaaaucaaggc .<<....>>..... .((....))..... Thogoto virus polymerase in Mode A conformation and bound to 35-mer loop promoter RNA; 5'RNA 8p16 2 1536 2.77 RF00177,RF01959,RF02542,RF01960 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaauucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggaucaccuccuua ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<..>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.............. ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((.(..).))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....))))))).............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}............. E167K RF2 on E. coli 70S release complex with UGG (Structure I); 16S rRNA 8p16 4 26 2.77 562 uaaggagguauuaaaugugggaauuc .......................... .......................... E167K RF2 on E. coli 70S release complex with UGG (Structure I); mRNA 8p16 5 76 2.77 RF00005 0030533 562 gcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... E167K RF2 on E. coli 70S release complex with UGG (Structure I); tRNA(fMet) 8p16 1 2899 2.77 RF02541 0003735 0005840 562 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<<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<..>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<<.<<....>>..>>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<..<<<<...........<<<<<..<<.......<<<<<<<<....>>>>>>>>....>>............>>>>>..>>>>..>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>.(<<...<<<<<<<...<<<<<<.......>>>>>>.....<<)..(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((.(((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))))))).)))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))..(((((((..((((((((((.....(((...(((.((((...(((((((.....))))).))...)))).)))..)).).....)))))).)))..)))))))).....(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{..((((.(((...(((.......)))...))).....(..(((......)))).))))....)))..))))).))...........]]].)...))))))))))...)))))))((((((((()))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((((((((..((((.(..........((((..(((.......(((((((....)))))))....)))............)))).).))))..))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).).....((.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..))....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). E167K RF2 on E. coli 70S release complex with UGG (Structure I); 23S rRNA 8p16 3 119 2.77 RF00001 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>> ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))) E167K RF2 on E. coli 70S release complex with UGG (Structure I); 5S rRNA 8p17 2 1536 2.78 RF00177,RF01959,RF02542,RF01960 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaauucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggaucaccuccuua ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<..>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.............. ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((.(..).))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))...(......)..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}............. E167K RF2 on E. coli 70S release complex with UGG (Structure II); 16S RNA 8p17 4 26 2.78 562 uaaggagguauuaaaugugggaauuc .......................... .......................... E167K RF2 on E. coli 70S release complex with UGG (Structure II); mRNA 8p17 5 76 2.78 RF00005 0030533 562 gcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... E167K RF2 on E. coli 70S release complex with UGG (Structure II); tRNA(fMet) 8p17 1 2899 2.78 RF02541 0003735 0005840 562 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E167K RF2 on E. coli 70S release complex with UGG (Structure II); 23S rRNA 8p17 3 119 2.78 RF00001 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>> ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))) E167K RF2 on E. coli 70S release complex with UGG (Structure II); 5S rRNA 8p18 2 1536 2.77 RF00177,RF01959,RF02542,RF01960 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaauucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggaucaccuccuua ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<..>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.............. ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((.(..).))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....))))))).............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}............. E167K RF2 on E. coli 70S release complex with UGG (Structure III); 16S rRNA 8p18 4 26 2.77 562 uaaggagguauuaaaugugggaauuc .......................... .......................... E167K RF2 on E. coli 70S release complex with UGG (Structure III); mRNA 8p18 5 76 2.77 RF00005 0030533 562 gcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... E167K RF2 on E. coli 70S release complex with UGG (Structure III); tRNA(fMet) 8p18 1 2899 2.77 RF02541 0003735 0005840 562 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<<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<..>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<<.<<....>>..>>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<..<<<<...........<<<<<..<<.......<<<<<<<<....>>>>>>>>....>>............>>>>>..>>>>..>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. 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E167K RF2 on E. coli 70S release complex with UGG (Structure III); 23S rRNA 8p18 3 119 2.77 RF00001 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>> ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))) E167K RF2 on E. coli 70S release complex with UGG (Structure III); 5S rRNA 8p2f A 2844 2.44 RF02541 38902339 0003735 0005840 93061 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((((((......((((((((((.....(((..(((((((((((((......((((((.[[..[[[)))...].((((((...(((]]..]].)))......))))))...)))....(((....)))(((((((......))))))).(((((((((.........))))))).)).))....(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...((((((((....))))))))....{.(((((((((.....((((.......((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))).)))))..)))))....(((((((...[.......)))))))....}.(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((..((((..[...))))..)))).<.(.(........).).((((((....(((((((.(((((..(((...(((.....)))...)))...((....))..((((.....)))).....))))).)))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)<)))...(((.(((((.......A))))))))..).))))))))).(.(((....[)))...).]))))))......).))..((((((....(((((....)))))(((((((((...(((((((((.....(((...((((((((....(........)....))))))))..)).).....)))).)))))..))))))).))..((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((.(((((.....{.(((((.(((..(((.........)))..))).....(...((......)).).)))))...))))).)))).))...........]]].)...))))))))))...)))))))(((((((...)))))))....))))))(.(((((((.((......(((((.((....))])))))...)).)))))))..).....))))))(......((....((((((.......))))))((((....(((...((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((((..((.......((...((((....((((..(((..(((((.((((((....{{...))))))((..(((((..(((((((((((.((.....))))))))).....))))..)))))...))...((((((.....))))))...)))))...)))...))))(..).....))))..))..))..))))))))))).))).....((......))..))).(((.......)))..))))..((((....((((((((.((..(....(.......(((((....(.[..).....)))))(((((((.((((....)))).)))))))(...).......(((((((((.>.((.........))...(((((((.....(((....))).......))))))).]((((.(((..(((((((..(((...((...(((((..((....))...)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).[..(((((.....>].)))))..((((((((.(((.((......((((.((((((..(((((.(((((((((.((((.(((.((((((..(..)..)))))).))).))))....((.((((((.....)))))))).....)))))))))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..a.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))..)))))...)))).)))))...(((....((.(.....}.......).))....))).))))..]....)))))))((((....)))....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))...))))))). Staphylococcus aureus 70S ribosome with elongation factor G locked with fusidic acid cyclopentane in post-translocational state; 23S ribosomal RNA 8p2f B 113 2.44 RF00001 38902339 0003735 0005840 93061 cuggugacuauagcaaggaggucacaccuguucccaugccgaacacagaaguuaagcuccuuagcgucgaugguagucgaacuuacguuccgcuagaguagaacguugccagg <<<<<<<<....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<......<<<.<<<<....>>>>.>>>......>>..>>>>>>>>. ((((((((....((((((((.....((((((...(.....)...))))..))....)))))).)).((.......((.((((....)))).)).......))..)))))))). Staphylococcus aureus 70S ribosome with elongation factor G locked with fusidic acid cyclopentane in post-translocational state; 5S ribosomal RNA 8p2f D 77 2.44 RF00005 38902339 0030533 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(((((.......)))))))))))..... Staphylococcus aureus 70S ribosome with elongation factor G locked with fusidic acid cyclopentane in post-translocational state; tRNA 8p2f F 76 2.44 RF00005 38902339 0030533 562 gcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Staphylococcus aureus 70S ribosome with elongation factor G locked with fusidic acid cyclopentane in post-translocational state; tRNA 8p2f a 1526 2.44 RF01959,RF00177,RF02542,RF01960 38902339 0003735 0005840 93061 auggagaguuugauccuggcucaggaugaacgcuggcggcgugccuaauacaugcaagucgagcgaacggacgagaagcuugcuucucugauguuagcggcggacgggugaguaacacguggauaaccuaccuauaagacugggauaacuucgggaaaccggagcuaauaccggauaauauuuugaaccgcaugguucaaaagugaaagacggucuugcugucacuuauagauggauccgcgcugcauuagcuaguugguaagguaacggcuuaccaaggcaacgaugcauagccgaccugagagggugaucggccacacuggaacugagacacgguccagacuccuacgggaggcagcaguagggaaucuuccgcaaugggcgaaagccugacggagcaacgccgcgugagugaugaaggucuucggaucguaaaacucuguuauuagggaagaacauauguguaaguaacugugcacaucuugacgguaccuaaucagaaagccacggcuaacuacgugccagcagccncgguaauacguagguggcaagcguuauccggaauuauugggcguaaagcgcgcguaggcgguuuuuuaagucugaugugaaagcccacggcucaaccguggagggucauuggaaacuggaaaacuugagugcagaagaggaaaguggaauuccauguguagcggugaaaugcgcagagauauggaggaacaccaguggcgaaggcgacuuucuggucuguaacugacgcugaugugcgaaagcguggggaucaaacaggauuagauacccugguaguccacgccguaaacgaugagugcuaaguguuagggggccccuuagugcugcagcuaacgcauuaagcacuccgccuggggaguacgaccgcaagguugaaacucaaaggaauugacggggacccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaaaucuugacauccuuugacaacucuagagauagagccuuccggacaaagugacagguggugcaugguugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuuaagcuuaguugccaucauuaaguugggcacucuaaguugacugccggugacaaaccggaggaagguggggaugacgucaaaucaucaugccccuuaugauuugggcuacacacgugcuacaauggacaauacaaagggcagcgaaaccgcgaggucaagcaaaucccauaaaguuguucucaguucggauuguagucugcaacucgacuacaugaagcuggaaucgcuaguaaucguagaucagcaugcuacggugaauacguucccgggucuuguacacaccgnccgucacaccacgagaguuuguaacacccgaagccgguggaguaaccuuuuaggagcuagccgucgaaggugggacaaaugauuggggugaagucgnaacaagguagccguaucggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<...<<<.........>.>>...>>>>.>>>>>......<<........<<<<<<<..<<...<<<<<<<.<<<<.....<<<<<<....>>>>>>......>>>>......<<<<<<<<<....>>>>>>>>>......<<<<<<...>>>>>>.>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<<<<<<<.......<.<<<<<<<........>>>>>>>.>........>>>>>>...>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<<..<<<.<<<<<<<.<<<<<<<<<.......<<<<<<.....>>>>>>.....>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>..>>>>>....<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<..>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<....<<<<<....>>>>>.........>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<......>>>>>...>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<..<<<<....<.<<<<..<<<..<<<...>>>.>>>.>>>>.>...>>>>..>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((.....((.........).).....))).)))))......(((.......(((((((..((...(((((((.((((.....((((((....))))))......))))......(((((((((....)))))))))......((((((...)))))).)))))))..))))))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..(.((((((...(.....(((((((........))))))).....)....))))))....).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))...).)))))))..)))))))))..(((.(((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))))..))..))))...))))....((((((....(...((((.........))))...).))))))......{...((((((..(((((((((((())))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((.((((....(((((....))))).........))))..))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..((......)))))...)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((..((((....(.((((..(((..(((...))).))).)))).)...))))..))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Staphylococcus aureus 70S ribosome with elongation factor G locked with fusidic acid cyclopentane in post-translocational state; 16S ribosomal RNA 8p2g A 2844 2.02 RF02541 38902339 0003735 0005840 93061 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((((((......((((((((((.....(((..(((((((((((((......((((((.[[..[[[)))...].((((((...(((]]..]].)))......))))))...)))....(((....)))(((((((......))))))).(((((((((.........))))))).)).))....(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...((((((((....))))))))....{.(((((((((.....((((.......((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))).)))))..)))))....(((((((...[.......)))))))....}.(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((..((((..[...))))..)))).<.(.(........).).((((((..(.(((((((.(((((..(((...(((.....)))...)))...((....))..((((.....)))).....))))).)))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)<)))...(((.(((((.......A))))))))..).))))))))).(.(((....[)))...).]))))))......).))).((((((....(((((....)))))(((((((((...(((((((((.....(((...((((((((...(.........)....))))))))..)).).....)))).)))))..))))))).))..((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((.(((((.....{.(((((.(((..(((.........)))..))).....(...((......)).).)))))...))))).)))).))...........]]].)...))))))))))...)))))))(((((((...)))))))....))))))(.(((((((.((......(((((.((....))])))))...)).)))))))..).....))))))(......((....((((((.......))))))((((....(((...((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((((..((.......((...((((....((((..(((..(((((.((((((....{{...))))))((..(((((..(((((((((((.((.....))))))))).....))))..)))))...))...((((((.....))))))...)))))...)))...))))(..).....))))..))..))..))))))))))).))).....((......))..))).(((.......)))..))))..((((....((((((((.((..(....(.......(((((....(.[..).....)))))(((((((.((((....)))).)))))))(...).......(((((((((.>.((.........))...(((((((.....(((....))).......))))))).]((((.(((..(((((((..(((...((...(((((..((....))...)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).[..(((((.....>].)))))..((((((((.(((.((......((((.((((((..(((((.(((((((((.((((.(((.((((((..(..)..)))))).))).))))....((.((((((.....)))))))).....)))))))))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..a.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))..)))))...)))).)))))...(((....((.(.....}.......).))....))).))))..]....)))))))((((....)))....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))...))))))). Staphylococcus aureus 70S ribosome with elongation factor G locked with fusidic acid cyclopentane with a tRNA in pe/E chimeric state; 23S ribosomal RNA 8p2g B 113 2.02 RF00001 38902339 0003735 0005840 93061 cuggugacuauagcaaggaggucacaccuguucccaugccgaacacagaaguuaagcuccuuagcgucgaugguagucgaacuuacguuccgcuagaguagaacguugccagg <<<<<<<<....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<......<<<.<<<<....>>>>.>>>......>>..>>>>>>>>. ((((((((....((((((((.....((((((...(.....)...))))..))....)))))).)).((.......((.((((....)))).)).......))..)))))))). Staphylococcus aureus 70S ribosome with elongation factor G locked with fusidic acid cyclopentane with a tRNA in pe/E chimeric state; 5S ribosomal RNA 8p2g D 77 2.02 RF00005 38902339 0030533 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(((((.......)))))))))))..... Staphylococcus aureus 70S ribosome with elongation factor G locked with fusidic acid cyclopentane with a tRNA in pe/E chimeric state; tRNA 8p2g a 1534 2.02 RF01959,RF00177,RF02542,RF01960 38902339 0003735 0005840 93061 auggagaguuugauccuggcucaggaugaacgcuggcggcgugccuaauacaugcaagucgagcgaacggacgagaagcuugcuucucugauguuagcggcggacgggugaguaacacguggauaaccuaccuauaagacugggauaacuucgggaaaccggagcuaauaccggauaauauuuugaaccgcaugguucaaaagugaaagacggucuugcugucacuuauagauggauccgcgcugcauuagcuaguugguaagguaacggcuuaccaaggcaacgaugcauagccgaccugagagggugaucggccacacuggaacugagacacgguccagacuccuacgggaggcagcaguagggaaucuuccgcaaugggcgaaagccugacggagcaacgccgcgugagugaugaaggucuucggaucguaaaacucuguuauuagggaagaacauauguguaaguaacugugcacaucuugacgguaccuaaucagaaagccacggcuaacuacgugccagcagccncgguaauacguagguggcaagcguuauccggaauuauugggcguaaagcgcgcguaggcgguuuuuuaagucugaugugaaagcccacggcucaaccguggagggucauuggaaacuggaaaacuugagugcagaagaggaaaguggaauuccauguguagcggugaaaugcgcagagauauggaggaacaccaguggcgaaggcgacuuucuggucuguaacugacgcugaugugcgaaagcguggggaucaaacaggauuagauacccugguaguccacgccguaaacgaugagugcuaaguguuagggggccccuuagugcugcagcuaacgcauuaagcacuccgccuggggaguacgaccgcaagguugaaacucaaaggaauugacggggacccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaaaucuugacauccuuugacaacucuagagauagagccuuccggacaaagugacagguggugcaugguugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuuaagcuuaguugccaucauuaaguugggcacucuaaguugacugccggugacaaaccggaggaagguggggaugacgucaaaucaucaugccccuuaugauuugggcuacacacgugcuacaauggacaauacaaagggcagcgaaaccgcgaggucaagcaaaucccauaaaguuguucucaguucggauuguagucugcaacucgacuacaugaagcuggaaucgcuaguaaucguagaucagcaugcuacggugaauacguucccgggucuuguacacaccgnccgucacaccacgagaguuuguaacacccgaagccgguggaguaaccuuuuaggagcuagccgucgaaggugggacaaaugauuggggugaagucgnaacaagguagccguaucggnnggugcggcuggaucaccuccuu .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<...<<<..........>>>...>>>>.>>>>>......<<........<<<<<<<..<<...<<<<<<<.<<<<.....<<<<<<....>>>>>>......>>>>......<<<<<<<<<<..>>>>>>>>>>......<<<<<<...>>>>>>.>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<<<<<<<.......<.<<<<<<<........>>>>>>>.>........>>>>>>...>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<<..<<<.<<<<<<<.<<<<<<<<<.......<<<<<<.....>>>>>>.....>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>..>>>>>....<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<..>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<......<<<<....>>>>...........>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<..<<<......>>>>>...>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<..<<<<....<.<<<<..<<<..<<<...>>>.>>>.>>>>.>...>>>>..>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............. .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((.....(............).....))).)))))......(((.......(((((((..((...(((((((.((((.....((((((....))))))......))))......(((((((((....)))))))))......((((((...)))))).)))))))..))))))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....((((((...(.....(((((((........))))))).....)....))))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))...).)))))))..)))))))))..(((.(((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))))..))..))))...))))....((((((....(...((((.........))))...).))))))......{...((((((..(((((((((((())))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((......(((....)))......).....)))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..((......)))))...)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((..((((....(.((((..(((..(((...))).))).)))).)...))))..))))))..))).))))..).))...)..)..(((((((((....)))))))))}............ Staphylococcus aureus 70S ribosome with elongation factor G locked with fusidic acid cyclopentane with a tRNA in pe/E chimeric state; 16S ribosomal RNA 8p2g b 16 2.02 38902339 562 aaggagguaaaaaugg ................ ................ Staphylococcus aureus 70S ribosome with elongation factor G locked with fusidic acid cyclopentane with a tRNA in pe/E chimeric state; mRNA 8p2h A 2844 2.49 RF02541 38902339 0003735 0005840 93061 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((((((......((((((((((.....(((..(((((((((((((......((((((.[[..[[[)))...].((((((...(((]]..]].)))......))))))...)))....(((....)))(((((((......))))))).(((((((((.........))))))).)).))....(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...((((((((....))))))))....{.(((((((((.....((((........(((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))))))).)))).)))))..)))))....(((((((...[.......)))))))....}.(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((..((((..[...))))..)))).<.(.(........).).((((((....(((((((.(((((..(((...(((.....)))...)))...((....))..((((.....)))).....))))).)))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)<)))...(((.(((((.......A))))))))..).))))))))).(.(((....[)))...).]))))))......).))..((((((....(((((....)))))(((((((((...(((((((((.....(((...((((((((....(........)....))))))))..)).).....)))).)))))..))))))).))..((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((.(((((.....{.(((((.(((..(((.........)))..))).....(...((......)).).)))))...))))).)))).))...........]]].)...))))))))))...)))))))(((((((...)))))))....))))))(.(((((((.((......(((((.((....))])))))...)).)))))))..).....))))))(......((....((((((.......))))))((((....(((...((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((((..((.......((...((((....((((..(((..(((((.((((((....{{...))))))((..(((((..(((((((((((.((.....))))))))).....))))..)))))...))...((((((.....))))))...)))))...)))...))))(..).....))))..))..))..))))))))))).))).....((......))..))).(((.......)))..))))..((((....((((((((.((..(....(.......(((((....(.[..).....)))))(((((((.((((....)))).)))))))(...).......(((((((((.>.((.........))...(((((((.....(((....))).......))))))).]((((.(((..(((((((..(((...((...(((((..((....))...)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).[..(((((.....>].)))))..((((((((.(((.((......((((.((((((..(((((.(((((((((.((((.(((.((((((..(..)..)))))).))).))))....((.((((((.....)))))))).....)))))))))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..a.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))..)))))...)))).)))))...(((....((.(.....}.......).))....))).))))..]....)))))))((((....)))....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))...))))))). Staphylococcus aureus 70S ribosome with elongation factor G locked with fusidic acid with a tRNA in pe/E chimeric state; 23S ribosomal RNA 8p2h B 113 2.49 RF00001 38902339 0003735 0005840 93061 cuggugacuauagcaaggaggucacaccuguucccaugccgaacacagaaguuaagcuccuuagcgucgaugguagucgaacuuacguuccgcuagaguagaacguugccagg <<<<<<<<....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<......<<<.<<<<....>>>>.>>>......>>..>>>>>>>>. ((((((((....((((((((.....((((((...(.....)...))))..))....)))))).)).((.......((.((((....)))).)).......))..)))))))). Staphylococcus aureus 70S ribosome with elongation factor G locked with fusidic acid with a tRNA in pe/E chimeric state; 5S ribosomal RNA 8p2h D 77 2.49 RF00005 38902339 0030533 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(((((.......)))))))))))..... Staphylococcus aureus 70S ribosome with elongation factor G locked with fusidic acid with a tRNA in pe/E chimeric state; tRNA 8p2h a 1534 2.49 RF01959,RF00177,RF02542,RF01960 38902339 0003735 0005840 93061 auggagaguuugauccuggcucaggaugaacgcuggcggcgugccuaauacaugcaagucgagcgaacggacgagaagcuugcuucucugauguuagcggcggacgggugaguaacacguggauaaccuaccuauaagacugggauaacuucgggaaaccggagcuaauaccggauaauauuuugaaccgcaugguucaaaagugaaagacggucuugcugucacuuauagauggauccgcgcugcauuagcuaguugguaagguaacggcuuaccaaggcaacgaugcauagccgaccugagagggugaucggccacacuggaacugagacacgguccagacuccuacgggaggcagcaguagggaaucuuccgcaaugggcgaaagccugacggagcaacgccgcgugagugaugaaggucuucggaucguaaaacucuguuauuagggaagaacauauguguaaguaacugugcacaucuugacgguaccuaaucagaaagccacggcuaacuacgugccagcagccncgguaauacguagguggcaagcguuauccggaauuauugggcguaaagcgcgcguaggcgguuuuuuaagucugaugugaaagcccacggcucaaccguggagggucauuggaaacuggaaaacuugagugcagaagaggaaaguggaauuccauguguagcggugaaaugcgcagagauauggaggaacaccaguggcgaaggcgacuuucuggucuguaacugacgcugaugugcgaaagcguggggaucaaacaggauuagauacccugguaguccacgccguaaacgaugagugcuaaguguuagggggccccuuagugcugcagcuaacgcauuaagcacuccgccuggggaguacgaccgcaagguugaaacucaaaggaauugacggggacccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaaaucuugacauccuuugacaacucuagagauagagccuuccggacaaagugacagguggugcaugguugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuuaagcuuaguugccaucauuaaguugggcacucuaaguugacugccggugacaaaccggaggaagguggggaugacgucaaaucaucaugccccuuaugauuugggcuacacacgugcuacaauggacaauacaaagggcagcgaaaccgcgaggucaagcaaaucccauaaaguuguucucaguucggauuguagucugcaacucgacuacaugaagcuggaaucgcuaguaaucguagaucagcaugcuacggugaauacguucccgggucuuguacacaccgnccgucacaccacgagaguuuguaacacccgaagccgguggaguaaccuuuuaggagcuagccgucgaaggugggacaaaugauuggggugaagucgnaacaagguagccguaucggnnggugcggcuggaucaccuccuu .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<...<<<..........>>>...>>>>.>>>>>......<<........<<<<<<<..<<...<<<<<<<.<<<<.....<<<<<<....>>>>>>......>>>>......<<<<<<<<<<..>>>>>>>>>>......<<<<<<...>>>>>>.>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<<<<<<<.......<.<<<<<<<........>>>>>>>.>........>>>>>>...>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<<..<<<.<<<<<<<.<<<<<<<<<.......<<<<<<.....>>>>>>.....>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>..>>>>>....<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<..>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<......<<<<....>>>>...........>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<..<<<......>>>>>...>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<..<<<<....<.<<<<..<<<..<<<...>>>.>>>.>>>>.>...>>>>..>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............. .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((.....(............).....))).)))))......(((.......(((((((..((...(((((((.((((.....((((((....))))))......))))......(((((((((....)))))))))......((((((...)))))).)))))))..))))))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....((((((...(.....(((((((........))))))).....)....))))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))...).)))))))..)))))))))..(((.(((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))))..))..))))...))))....((((((....(...((((.........))))...).))))))......{...((((((..(((((((((((())))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((......(((....)))......).....)))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..((......)))))...)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((..((((....(.((((..(((..(((...))).))).)))).)...))))..))))))..))).))))..).))...)..)..(((((((((....)))))))))}............ Staphylococcus aureus 70S ribosome with elongation factor G locked with fusidic acid with a tRNA in pe/E chimeric state; 16S ribosomal RNA 8p2h b 16 2.49 38902339 562 aaggagguaaaaaugg ................ ................ Staphylococcus aureus 70S ribosome with elongation factor G locked with fusidic acid with a tRNA in pe/E chimeric state; mRNA 8p2k B5 3764 2.9 RF02543 URS000231197F_9986 37347872 0003735 0005840 9986 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcgguggggcgcgggaaauguggcguacggaagacccacuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagngngaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcgugguccggccgugccggcggucucggcggaucuuucccgcuccccguuccuggggguggggucggcgggggaccgccccccggccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggccccggcggggaagguggcccggggggacgccucgccgccgucguccgcggcggcggcgggcgcgaccccuccccggguguuacagccccgccccggcagcagcagcucgccgaaucccggggccgagggagcgagaccugugucgccgcgcucuccccccucgggggggccgggccgccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgugucacgccgucgggcucgggggaggccacggcgcgucgcgcgccggcgcgcgcgcgcgagcgagcgcacggggucggcggcgaugucggcuacccacccgacccnucuugnaacncggaccaaggagunuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcggcggcgccgucgucggccgaggugggaucccgaggcccuuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccnanagauggugancuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauagnggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcaaccccgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcngaacuggcgnugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgcuggcagucggcagagcgagaaagagaguggagccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaunuuggugguagunnnaaauauucaaacgagaacuuugaaggccgaaguggngaaggguuccaugngaacagnanuugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucagccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccnuauccgcagcaggucuncaaggugaacngccucuggnauguuggaacaanguagguaagggaagucggcaagcnggauccguaacuucnggauaaggauuggcucuaagggcugguagcagccgacuuagaacuggugcggaccaggngaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugccnagugcucugaaugucanagugangaaauucaaugaagcgcggnuaaacggcgggaguancuaugacucucuuaagguagcnaanugccucnucaucuaauuagugangcgcaugaanggaugancgagnuucccacugunccuaccuacuauccagcgaaaccacngncaagggaacgggcuuggnggaaucagcggngaaagaagacccuguugagcuugacncuagucuggcacggugaanagacaugagagguguagaauaagugggaggcccgggccgccggugaaauaccacuacucuuaucguuuuuucacugacccggugaggcgggggggcgagccccgaggggcucucgcuucuggcgccaagcgccgggccccgucgguccgggccggcggcggccgggcgcgacccgcuccggggacagugccagguggggaguuugacugnggcgguacaccugucaaacgguancgcaggnnuccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucagnacgaauacagaccgugaaagcggggccucacgauccuucugagcuuuuggguuuuaagcaggangugucagaaaaguuaccacagngauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuungaugucggnucuuccuaucauugugaagcagaauucaccaagcguungaunnuucacccacuaauagggaacgugngcugggnuuagancgucgugagacagguuaguuuuacccuacugaugnuguguuguugccaugguanuccugcucaguacgagaggaaccgcagnuncanacauuugguguaunugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgaaggagccucgguuggccucggauagccggucccccgcgggguccggugcggagagcccuucgucccgggaaauggggcgcggccggaaagggggccgcccucucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<...<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>...<<<<<<<<<....<<<<<<<<.<<<....<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>>>>>>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<<....<<<<<<<.<<<<<.<.....<<<<<.<<<..<<<<<<<<<<<<<<....>>>>>>>>..>>>>>>>>>>>>>>.>>>>>>>>>>...>>>.>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<.<<<<<<<<<<.<<<<...<<..<<<..<<<<<<<......<<<<<<<<<<....<<<<<<<<<<<<<<..>>>>>>>>>>>>>>........>>>>>>>>>>.......>>>>>>>..>>>.........>>>>>>...>>>>>>>>>>.....<<.....[[>>......<<<<<<.<<<<<<<.>>>>>>>.<<<<<<.<<<<.<<<<<<<<<.<<<<<<<<<<<<<<.<<<<....>>>>.>>>>>>>>>>>.>>>.>>>>>>.>>>...>>>>..>>>>.>><<<<<.<<<<<<<..>>>>>>>>>>>>....>>>>>>......>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<<<<<<..>>>>>>>>>>>>..<<<<<...<<<..<<....((((.{{..>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<..........<<<.<<<<<<<<<...<<<....<<<....<<<..<<<<<<.<.....>.>>>>>>>>>....>>>..>.>>...>>>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<.......]]...........}}.))))..............>>>>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<<<<<...>>>>>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<...<<<<<<<....>>>>>>>...<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<...............<<<<<...............>>>>><<.<<<<<<<<<<<....>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<<<<<<<<<<<..........<<<<<..<<<<..>>>>............>>>>>.>>>>>>>.>>>>>>>>>>...<<<<<.....<<<<..<<.<<<<<<<..>>>>>>>>>..............<<<<<.<<<<<<<<<<<<<..>>>>>>>>>.>>>>.>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>>.<<<....>>>.>>)))].....<<<<<<<..<<<..)))))).>>>>>>>>>>.........>>>>..>>>>>>.......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<.]]]..>>>>..>>.>>...>>>>...>>>><<<<....<<<<<...........>>>>>....>>>>.>>>...>.>>>>>>.....<<<<<<<..<<..<<<<....<<<........<<<<<..<<<<..>>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<........>>>>>>>>>>...>>>>..>>>..............>>>>..>>>>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<.<..<<<<<......>>>>>..>>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..(((((((((((.....)))))).))))....))))....(((((((((....((((((((.((.....((((((((..({((((......)))))....[[(...).(((....}]])))...).))))))).))))))))))...)))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....((((((((((.(..(((((((.(((((.((....(((((.((...(((((((.(((((((()))))))).)..)))))).))))))))))))))))))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((..(((((((......((((((((((....(((((((((((((....)))))))))))))........)))))))))).......)))))))..))).........))))))..))))))))))).....((.....{{))......((((((.(((((((.))))))).((((((.((((.(((((((((.((((((((((((((.((((....)))).))))))))))).))).)))))).)))...))))..)))).))(((((.(((((((()))))))))))))..[.)))))).....))).)))))...)))))...)))))))).<((((........))))((((((....(((((((((((((..(((..(((((........))))..)..)))...((....))...((((((((((((()))))))))))))..(((((...(((..((.(].[[[[.[[[)))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......B)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((..........(((.((((((((.....((.....((.....((...((.((.........)).)).)).....))...))......))))))...(((((((((.(......))))))))))....))))))))))))..))..((((..(.((.....)).)..))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.....A.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((.......}}.........].]].]]]].(...)........)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((..(((((((...((.....)).))))))....[[(((.((...(.....(((....)))...(.)....((.(((((((((...))))))))))).......)....))...(((((........)))))]]((((....(((((...((.((((....)))).))..((((....)))...(...((((((...((((((((((((((((((((((...{{{...)))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....(((((((.......))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).))).))).....((......)).)))).((((.....))))..)))....(((......((((((..((..(....(.......(((((....(.[..).....)))))((.(((((((((((....)))))..)))))).))(...).......(((((((((.>.(...........)...(((((((....((((.....))))......))))))).].(.(.(((..((((((.(...(......((.(....).))......).)))))..)))))(.(.(.........).).)........((..........(((((.......)))))..)..)....).)....)).))))))).)..)))..))))))...)))))....)).[..((.((.....>].)).))....(((((..(((.((......((((.(((((...(((((.(((((((((.(((((((...(((((((.......[..(((((..((((()))))..........].))))).)))))))....)))))))...(((((.....((((..((.(((((((..)))))))))..............(((((.(((((((((((.(()).))))))).)))).)))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(..((.(..((....{..))...))).)(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}.....)))..)))))).......(....(.((((.(...((.......))...).))))...)....)........((((.((((((..(.(.(.(((......))).)...).).(((.(.....).))).....)))))..)...))).)......((((((....))).)))...b.))..))).))))).....(.((.(.(..(((..(.(((((......(....).....))))).)(((.....((((....((.(((((((}}}.)))))..)).))...))))....))).((((...((((.....a.......))))...))))..)))...).).)).).....(((((((..((..((((.(..(((.........((((..((((())))).))))........)))...(((..((((....((((.((((((........))))))))))...))))..)))...........)..))))..)))))))))(((((....(.......).......((.(((((((.((.....(.((.(..(((((......)))))..))).)....))....)))).))).))..))))).. Ternary complex of translating ribosome, NAC and METAP1; 28S rRNA 8p2k B7 119 2.9 RF00001 URS000002B0D5_9986 37347872 0003735 0005840 9986 ucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>... ((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))... Ternary complex of translating ribosome, NAC and METAP1; 5S rRNA 8p2k B8 156 2.9 RF00002,RF02540 URS00023119A4_9986 37347872 0003735 0005840 9986 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauuncaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<<<<....>>>>.....<.<<<......>>.............>>>..>...>>>....<<....>><<<<<<<<<.....>>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))(((((((((.....))))))))).................... Ternary complex of translating ribosome, NAC and METAP1; 5.8S rRNA 8p2k A2 1770 2.9 RF01960,RF02542,RF01959,RF00177 URS00023119C9_9986 37347872 0003735 0005840 9986 uaccugguugauccugccaguagcaunugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucnuuaaaucaguuauggunccuunggucgcucguacuuggauaacugugguanuucuagngcuaananaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucagaucaaaaccaacccggugccggcggcuuuggugacucuagauaaccucgggccgaucgcacgcccuccguggcggcgacgacccauucgaacgucngcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgaunccggaganggagccugagaaacggcuaccacauncaaggnaggcagcaggcgcgcnaauuacccacucccgacccggggangungugangaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaanuccuuuaacgaggnuccauuggagngcaagucuggugccagcagccgcggnaauuccagcuccaauancguauauuaaaguugcugcaguunaaaagcucguaguungaucuugggagcgggcggccgcccguccccgccucucggcgccccggggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaaungaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagancgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacncaacacgggaaaccucacccggcccggacacggacagganugacagauugauagcucuuucucgauuccguggguggngnugcauggcnguucuuaguugguggagcgauuugucugguuaauuccgauaacgancgagacunuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuncuuanagggacaaguggcguucagccacccgagauugagcaauaacangucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgagnaauucccaguaagugcgggucauaagcuugcguugauunagucccugcccuuuguacacaccgnccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggucggcccacggcccuggcggagcgcugagaagacggucgaacungacuaucuagaggaaguaaaagucguancaagguuucnguaggugnnccugcggaaggaucauua ...<<<<<...[[[[>>>>>[[[.((((((.....{{.........[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[......{{....[[[{..........<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<<<....>>>>>>...>>>>[[..(((((.....<<<<<<<<<<<<<..>>>>.......<......>..)))))......]]...<<<<.<<<<......>>>>>>>>..}.]]]...}}....]]].<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<<...>>>>..>>>......}}.......<<<<<<<<<.<<<....>>>..>>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..)))))).]]]............{{.......{{...[[[.[[....<<<.<<<<<<<..>>>>>>>.>>><<...<<<..<<<<..>>>>.>>>.>>..<<<<<<.<.......<<...<.......>.<<<<.......>>>>...>>......>.>>>..>>>........{.[[.(((((((.....>>>>>>>>>.))))))).]].}....]]....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<<....>>>>>>>>>>>.>..>>>...<<..}}>>...>>.....>>>.....<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<........<<........>>..........<<<<<......<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<.......>>>>.>>>>.....>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.......>>>>>......>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<<<<<<<<<<<<<<.....>>>>>>>>>>>>.>.>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))((...(((((......(..((.....(((.(((..((....((....((..........))...)){))......(((.......(((.(.(..((....(((.....(({...((.....((.(((.....))).))......))......)).((((...(((((......)))))...))))((..(((((.....[.[[[[[[[.(((())))........(......)..)))))......)).(}((((.((((......)))))))))...)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((....(((.}...)))..)))).)...)........(((((((((.(((....)))..)))))).)))....(.((..(...........)..))......)..((((([[....(.(.((.....((..]])).......)).)))))))..)))))...))..{......(.({{...(.(.((...(.(..(....(((.(((((((()))))))).)))(......(..((((())))).)....)..(..(((.(........(..((.......)).((((...)..)))....).......).)))....)........(.((.(((((((.....]]]]]]].].))))))).)).)....)....(((..(...(...(((...((..((((((((...(..........)......))))))))..)).......((....))....)))..)...)...))..)).)...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..(.((((((.(((((....))))))))))).)..)))...((..}}))...))...}.))))).).(((......((.(....).))....)))...]]].]((((..(((((((..((..((.((..(((..(((((.......(........)...........(((((.(....(((((........(..(((........)))..)......)))))...((.(((...(.((((((.(..((..(((((....)))..(.((......)))...))..))....(((...(...((.(..(((((((((((((....).)))).)))).....))))..).))..).....(((((.....)))))........))).)..))).))).....).))))).....).)))))...)).)))..))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....((((............)))).....)..)..)).)).....((((((((.......))))))))......))...))))))).)).))..(.(..((.(..((((.((..(.((((((((.(((..((((.((...((((((.((.(.((((((.....)))))).).))..).)))))...)).))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>........ Ternary complex of translating ribosome, NAC and METAP1; 18s rRNA 8p2k AT 76 2.9 RF00005 URS0000868532_9986 37347872 0030533 9986 guuuccguaguguagugguuaucacguucgccuaacacgcgaaagguccccggnucgaaaccgggcggaaacacca <<<<<<<..<<<..........>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..(((.....[....))).(((((.......))))).....(((((..]....)))))))))))).... Ternary complex of translating ribosome, NAC and METAP1; P-site Val-tRNA 8p4v 1 3149 3.16 RF02540,RF02541,RF02543 0003735 0005840 4932 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(((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). 80S yeast ribosome in complex with HaterumaimideQ; 5S ribosomal RNA 8p4v 4 158 3.16 RF00002 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... 80S yeast ribosome in complex with HaterumaimideQ; 5.8S ribosomal RNA 8p4v AR 3147 3.16 RF02540,RF02541,RF02543 URS000061F377_4932 0003735 0005840 4932 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...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((...............(.....((.(((.....))).))......).........(((((..((....))..)))))(.(.((((((......[.[[[[[..((....))......(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(((((.(................).)).)))......(.(.(...........))..).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((..(.(.....).)......))).))))))....((((((....((...(((.......)))...))....))))))...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(((..(..(((((.....]]]]].].)))))..).))).....))...(((..((..(...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)..))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((......(((.(........((.(((........))).))......).)))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..(.((..(.(((.((((((....))))))...))).)..)).).))..(.((((((.....))))))....)..)))))....))).))).....).))))).......)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..(.((..(...(((((((.((..................)).)))))))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>........ 80S yeast ribosome in complex with HaterumaimideQ; 18S ribosomal RNA 8p5d L50 2499 10.8 RF02543 URS00026177A1_1358809 37709902 0003735 0005840 1358809 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....<<<<<<<<<......((..((<<<<<<...<......<<<<<<.((.....>>>....<<<<<<..<..))..>.....>>>>>>...>>>.....<<<<<...>>>>>>....<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..<<<...........<<<<<<..>>>>>>............<<<<<<<<<<...<<<<.........>>>>((......<<<.....))>>>...>>>>>>>>>>..............<<<<<<<........>>>>>>>....<<<<<..<<<<<.>>>>>..>>>.........>>>>>>.))...............<<....>>....)).......>>>>>>>>>..<<<<<.....>>>>>.<<<<........>>>><<<<<<....<<<<.<<<<<<<<..<<<..<<<<<.....>>>>>..>>>...<<....>>.....>>>>>>>>.>>>>..<<.<..<<<<<.<<.....<<<<<<<<<<<<<<....<<<<<<<....>>>>>>>.....>>>>>.<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<..<<<<<.<<<<<<<.....<<<......<<<...<<<<..>>>>..>>>.....>>.>.....>>>>>..>>>>>..>>..>>>>.>>..<<.<<<<<<<.....>>>>>>>.>>....<<<......>>>...<<<<<<<...<<<.((...<<<<<<<.....<......<<.<<<<<<<<<<<...>>>>>>>>>>>>>..........))..>...>>>>>>>>>>...>>>>>>>.........>>>>>><.<<<<<<<<<<......<.<<<<<<....>>>>>>.>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<......>>>>>>.<<<.....<<<<..<<...<<<<<<....>>>>>>....((<<<<<<...<<..<<<<......>>>>..>>....>>...<<<<<........>>>>>))<<<<<<<<<<..<<<....>>>....<<<.<<<<<...<<<<.<<<<..<<<<<<<<<<<<...[[..>>>>>><<..<<<..<.<<<<<<<<.....<<<<...>>>>.....>>>>>>>>.>.>>>..>><<<<<<....>>>>>>>>>>>>...>>>>.>>>>.........>>>>>>>>...>>>>>>>>>>>>>>..>>..<<......>>.>>>>.<<<<.....>>>>..>>>....<<.....<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<....>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<........>>>>>>>..<<<..<<<..<<<<<<<.<.<<.....<<........>>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>.....>>.>..>>.>>>>>>>..>..>>.>>>>>>>..>>..>>....>>....<<<<<........>>>>>..[[.<<<..<<<.[[......<<<<.[[<<<<..<<<<<.<<.<<<<<..<<<<<<<.<<<<..<<<<..>>>>..>>>>.>>>>>>>...<<<....>>>......>>>>>.>>..>>>>>...<.<.....>.>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<.........>>>>>....<<..[.(((.>>...>>>>>>>...<<<<<<<<......>>>>>>>>..<<<....>>>.>>)))]......<<<<<<.<<<...>>>>>.>>>>>>>>>..........>>>>..]]>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>..>>.......<<<<<.<<<<<<..<<<.<<<<<......>>>>>...>>>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..>>>.>>>.]]...<<<....<<<<.<<<<<<..................>>>>>><.<<<...<<<<...<<<<.<<<<.]]...>>>>.>>>>...>>>>.>>>.><<<<....<<<<<...........>>>>>....>>>>>>>>....>>>...<<<<<.<<<<.......>>>>....<<<<<<<<<<<<<....<<<<<..<<<..<<<...>>>.>>>..>>>>>...>>>>>>.>>>>>>>...>>>>>.. ...((((((((((.....(((..((((((((.(.(......((((((.[[.....)))....((((((..((.]].)).....))))))...))).....((((.....)))))....(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........((((((....)))))....).......((((((((((...((((.........))))[[(...).(((.....]])))...)))))))))).........)....(((((((........)))))))....(((((..[[[[[.)))))..)))......)..)))))).))...............((....))....)).).....)))))))))).(((((.....)))))[((((........))))((((((..(.((((.((((((((..(((..(((((.....)))))..)))...((....)).....)))))))).))))..((.(...((((.((.....(((((((((.(((((...(((((((....)))))))...)[))))..(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))).((((((....(((((....)))))((((((..(((((.(((((((.....(((....(.(((...(((....)))..))).)...)).).....)))))..)))))..))..)))).))..((.(((((((.....))))))).))....(((......)))...(((((((...(((.[[...(((((((.....(......((.(((((((((((...)))))))))))))..........]]..)...))))))))))...))))))).........))))))(.((((((((((......(.((((((....)))))).)...))))))))))..).....))))))((.....((.....((((((......)))))).(((.....((((..((..(((((((....))))))....[[(((.((...((..((((......))))..))....))...(((((........)))))]]((((((((((..(((....)))....(((.(((((...((((.((((..((((((((((((...{{..))))))((..((.....((((((((.....(((.....))).....))))))))....))..))((((((....))))))))))))...)))).))))(...)....))))))))...)))))))))).))).)))..((......)).)))).((((.....))))..)))....(......(((((((.((..(....(.......(((((....(.{..).....)))))((((((....))))))(...).......(((((((((.].((.........))...(((((((........))))))).}.(((.(((..(((((((...((.....((........)).....)).)))))..)))))(((((.........)))))........((..........((((((.....))))))..)..)....)))....)).))))))).)..))).)))))))...)..))....)).{..(((((.....]}.)))))..((.(((..(((.((......((((.((((((..(((((.((.(((((..(((((((.((....(((....)))....)).)))))))...(((....)))......))))).))..)))))..(((......[)).)((((((..........]))))))(.((...(((((((.(.(((((....(..).)))))...).(..[.[[[.)....)))))))...(((((((((....)))))))))..(((....))).))]]].].....((((((..((...]]]]].)).))))))....).....))))..)))))).......(..(.(..(((((...((.......))...)))))....))...)........((((.((((((..(((.(((((......)))))...))).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).))).))...(((....(((..((((((.......(....).....))))))(.(((...((((...((((.(((((}}..))))).))))...)))).))).)((((....((((.............))))....)))).)))....)))...(((((.((((.......))))..(.(((((((((((((....(((((..((....((...))...))..)))))...)))))).))))))))..))))).. Spraguea lophii ribosome in the closed conformation by cryo sub tomogram averaging; RNA 28S 8p5d L70 119 10.8 RF00001 URS00026177A4_1358809 37709902 0003735 0005840 1358809 aguuacggccauaucuacugaaaaacaccggaucccguccgaucuccgaaguuaagccaauaagagccaugcgaguauuaaggugggcgacuacuugagaaagcguggugcuguaguuu <<<<<<<<<....<<<<.<<......<<<<<..............>>>..>>.....>>.>>.>><<<<<<<.....<<<<<..<<....>>.>>>>>....>>>>>>>>>>>>>>>>. ((.((((((....((((.((......((((((...(....)...))))..)).....)).)).))((((((......(((((..((....)).))))).....)))))))))))).)). Spraguea lophii ribosome in the closed conformation by cryo sub tomogram averaging; RNA 5S 8p5d S60 1354 10.8 RF02542 URS000261779A_1358809 37709902 0003735 0005840 1358809 accagguugauucugccugacguggaugcuagucucauagauuuagccaugcauguguaagcgaagcgauuagugaagcggcggaaggcucaguaacgggcgaguauuuaaucucuagaaccggacaaccucaggaaacagaggggaaaacggaguaagagcauguguuagcaugugaugagaacaacagugcaggagaguaagaagccaucccaucaguuaguaaguaggguaagggccuauuuagacguagacggguacgggggauuaggguuugauuccggagagggagccugagagacggcuaccagguccaaggacagcagcaggcgcgaaaauuaccgaagccuccaagagggcgguagugaagagacgugaaaacaaguguguguaaaaaccacaugaguaacuggaggucaaggcuggugccagcauccgcgguaauaccagcuccaggagugucuaugaugauugcugcgauuaaaagguccguagucgaagaacaguacuuguuuguaauguggcuuaucgagagccgaauagaacgagaagaguucagaguaaggagcgaaggagggcuagauuauugagcagcgagaggugaaauuugaugaccugcuuaggaguaacagaggcgaaagcgcuagucaagaacgaauccgaugaucaaggacguaggcuggaggaucgaagacgauuagagaccguaguaguuccagcaguaaacgaugccuacgcuguugugguuaugagcacggcagaagagaaaucuaguagggcuuuggggagaguacgcgcgcaagcgauaaauuuaaaggaaauugacggaagaacaccacaaggaguggagugugcggcuuaauuugacucaacgcgggacagcuuaccauacccgauggccgugugagcguaguacgcgauaggucagagaguggugcauggccguuaacgacgaguggggugaccuuuggguuaaguccgcgaaguagugagaucccuaggauacgaaaguuaucgacagguguuaaaaacacaggaaggaaggggcaagaacaggucagugaugcccuuagaugguaugggcugcacgcgcacuacaguggucacagcagaaacaaauagaaguaaaugugaucgagagggaaugagcacuguaaugugcacaggaacgaggaauugcuaguaaucguuaucucauuaagaagcgaugaaugugucccuguucuuuguacacaccgcccgucguuaucgaagauggaaccaggugcgaacaagugaaagcgagugagugcaggguucuagaucugauacaagucguaacaaggcagcuguaggagaaccuguagcuggauca ..<<<<<.[.(((.>>>>>.<<<<<<<<<..<<<<<.<.......<<<.<<<..<<....<<...<<.....>>...>>.>>......<<.......<<<<.....<<...<<<<<.<..<<<.....<<<<.<....>.>>>>......>>>....<..<<<<<<....>>>>>>..>....<<....>>.>.>>>>>..>>...>>>.><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>..<<<<..>>>>....>>>>>>.........<<<....<<<<...>>>>..>>>...>..>>>>>..........<<<<<.........>>>>>......<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<...<<<<....<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>....>>>>.......<<<.<<......<<<<<<..<.<<<<<<<<...<<<......>>>......>>>>>>>>..>........<<....>>.>>>>>>.....>>..>>>...>>>...>>>>..<.<<<<<<<...<....<<<.........>>>....>>>>>>>>..>.......<<<.<<.<<<<<<<<.<<..>>.>>>>>>>>..<<..))>>..>>..>>>.>>>.<<<.......<<<....>>>.....>>>....))).]<<<<<.<<<<<<<..<<..<.<<<..<<<<<<<<<<......<<........>>..........<<<<<<<...<<<<<......<<<<...>>>>....>>>>>..<<<.<<<..<<.<<<<<<....<<.<..<<<....>>>...<<......>>......>.>>....<<<<..<..<<<....>>.>.>.....<<<<.....>>>>.........>>>>....>>>.>>>.....>>>>>>>>....>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....................>>>>>>>.........<<.<<<<......>>>>.>>..........>>>.>.....<<<<<..<<.......>>.>>>>>......>>...>>>>>>>>>>.>>.......<<.<..<<<<<.<...<<<<<<..<<<<..<<..<<....>>..>>..>>>>..>>>>>>...>.>>>>>...>.>>.........<<<<<<<<<....>>>>>>>>>...... ..((((..[.[[[..)))).(((((((((..(((((.(((.....(((.(((..((....((...((.....))...)).))......(((.......(((...(.((...(((((.(..(((.....((((.(....).))))......)))....(..((((((....))))))..).....(....)..).)))))..)))..)))..(((....(((..(((.((((.......)))).))))))......)))..(((.((((....))))....)))))).((.(((..........))).))..(((....)))....)))))).).....(.(((...(((((...)))).))))).))..)))))..........(((((.........)))))......((((([[....(.((((.....((..]])).......))))))))))..)))))))))..........((([[...(.((((...(((...((((....(((((((......((((((.....))))))....)))))))....))))......((((.((......(((((((....(((((((...((........))......)))))))....).......((....)).)))))).....))..)))..))))...))))....((((((....(....(((.........)))....).))))))......{...(((.((.((((((((.(....).))))))))..((..]]))..))..))))))).(((.......(((....))).....)))....]]].](((((.(((((((..((..(.(((..((((((((((......((........))..........(((((((...(((((......((((...))))....)))))...((.(((...(.((((((....(..(.((((....)))...((......))....).)..).....((.(.(...((....))...)..(..((((.....)))).....)..).)).....))).))).....).))))).....)))))))...)).)))))))).(...(((((((.....................)))))))....(....((.((((......)))).))....)..)..))).).....((((((.((.......))))))))......))...)))))))))).))..(.(..((.(..(((((.(..(((((((..((((..((..((....))..))..))))..)))))))..).)))))...).))...)..)..(((((((((....)))))))))}..... Spraguea lophii ribosome in the closed conformation by cryo sub tomogram averaging; RNA 16S 8p60 L50 2499 14.3 RF02543 URS00026177A1_1358809 37709902 0003735 0005840 1358809 auaccacacacaagggaucguuuggcuccugggacgaggaagggcgcagcagagagcgauaugugugggagcagcagcaaugaccacacguccccgaauacagcauagugcuggaguacuccuuggaauuaagcauaugaguaaaggaaggaaaagaaacuaacgaggauucccguaguagcggcgagugaacagggaacaguccaacaguguaauucucaaaugagaaguugucaaaaggaagaagaugugaaucagaaagaaaagcugaacgauacagggugauagucccguagugucuucuuacauacggugaguagcugugcucgguaaugcacagugaagagguggcagugugcaucuaagacuaaauacaacaggagaccgauagcaaagaaguagguugaccgaaaacagugaaauuguguguggacccgaauggaucgggcccgucuugaaacacggaccaaggagugcacauacacugcaaguugagcagaggaagucugugaggcguagugaagacggaaagcagugugagugcgacccgauagacuugugaacuauaccuuguugcugugaaggcuggcgaaagccagcuggaggcggcaagccguauugaucugcaaaucauuggcguaagcaggguauaggggcgaaagaccaaucgaacagucuaguugcugguucccuccgaaaugucuaucaggacagcgcgcacgcagagagaagcaagguagagcaugggccgguauccuuaaggagacggacgaacugcgaaugugcuuuucuucuaugcaagcguagugggcgaguucugguaagcaggacuggcgaagaggaaugaaccuggcacugugcuaaggaacccaaugucuggacagagaccgaaagagguaggugaauaaaauucaucugcucugaaaauugauggcgcuuaccagacauccgaugcacaguuagcagguaggagggcgugugucuacuggcgaagguaccgagugaucggugguggagguagaugcagagcagaucuuggugguaguagcgauaauuugucuucagcggcaaagacugaggaggagaaggguuucuucucauaagaagagugagccgggucuaagcgaguguguagaagcaugagcgaaggagaaacagguugauauuccugugccugugcugucguacggcaacguguauuagcuugucgacacgaacaucuagacaaagcagaaacaccuuuucuguucaaggggaaaaagaccacugagacggaucaucuggcgacgugguuuuauaucugugaccaggccugagccugguuuguugaggauggucguccaugaaaagacaacuauauggcagcacaguccguaccaaccguaucaggacuccaaggugaagagccucuaguggauguuuuacacauguaagggaauucggcaaaauggaugcguaacuucgggagaaguauugguucaauugugaacucauugugacaaggggaaucugacuguuuaguaaaaacauagcuucaugaagagagaugaagugaguucugcccggugcucggucgugacacggaggaaaugccagaaagcacggguuaacggcgggaguaacuaugacucucuuaagguagccaaacgccucgucauuuaaauggugacgcgcaugaauggaaugacgagauucccacugucccuacauguagacuagcgaacccauuuccaggggaacgggccuggacggccagcggggaaagaagacccuguugagcuugacucuaguguggccaaguugugacgauugaggcgagcgccaugaucaucacgacacacuuguuuaaggacaaaggccagauggggaguuuggcuggggcgguacgaccacagaaucagaacguggucgaccgaagguacucacagcgagacgagaacacucguguagagcauaaggacuaaagagugccugagugugagcacuacugcuugcaugaggggaaacccgggccuagcgauccuacgcauacgagacacuuguggcgugggugucagaaaaguuaccacagggauaacuggcuuguggccgccgagcguagaaagcgacgcggcuuuuugauucuucgaugucggcucuuccuagcauggccaugcagccguggcgaaguguuggauuguucacccacuaacagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuauccuacuguccaaacaguugaagggaguguggauuaguacgaaaggaaacccacacgugaccucuggugcagcgggugugcggaagugcaacugccaugcuacgucuccucaagcauagcuggaagccucuaagcuagaaaugaguccugacucuggaagacggccgggaagacgacccguaguuaacagcgguguuguacgauaugagcuuucuauuguaguagcgaguauuugagacacugguuguuaccaccgucgu ....<<<<<<<<<......((..((<<<<<<...<......<<<<<<.((.....>>>....<<<<<<..<..))..>.....>>>>>>...>>>.....<<<<<...>>>>>>....<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..<<<...........<<<<<<..>>>>>>............<<<<<<<<<<...<<<<.........>>>>((......<<<.....))>>>...>>>>>>>>>>..............<<<<<<<........>>>>>>>....<<<<<..<<<<<.>>>>>..>>>.........>>>>>>.))...............<<....>>....)).......>>>>>>>>>..<<<<<.....>>>>>.<<<<........>>>><<<<<<....<<<<.<<<<<<<<..<<<..<<<<<.....>>>>>..>>>...<<....>>.....>>>>>>>>.>>>>..<<.<..<<<<<.<<.....<<<<<<<<<<<<<<....<<<<<<<....>>>>>>>.....>>>>>.<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<..<<<<<.<<<<<<<.....<<<......<<<...<<<<..>>>>..>>>.....>>.>.....>>>>>..>>>>>..>>..>>>>.>>..<<.<<<<<<<.....>>>>>>>.>>....<<<......>>>...<<<<<<<...<<<.((...<<<<<<<.....<......<<.<<<<<<<<<<<...>>>>>>>>>>>>>..........))..>...>>>>>>>>>>...>>>>>>>.........>>>>>><.<<<<<<<<<<......<.<<<<<<....>>>>>>.>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<......>>>>>>.<<<.....<<<<..<<...<<<<<<....>>>>>>....((<<<<<<...<<..<<<<......>>>>..>>....>>...<<<<<........>>>>>))<<<<<<<<<<..<<<....>>>....<<<.<<<<<...<<<<.<<<<..<<<<<<<<<<<<...[[..>>>>>><<..<<<..<.<<<<<<<<.....<<<<...>>>>.....>>>>>>>>.>.>>>..>><<<<<<....>>>>>>>>>>>>...>>>>.>>>>.........>>>>>>>>...>>>>>>>>>>>>>>..>>..<<......>>.>>>>.<<<<.....>>>>..>>>....<<.....<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<....>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<........>>>>>>>..<<<..<<<..<<<<<<<.<.<<.....<<........>>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>.....>>.>..>>.>>>>>>>..>..>>.>>>>>>>..>>..>>....>>....<<<<<........>>>>>..[[.<<<..<<<.[[......<<<<.[[<<<<..<<<<<.<<.<<<<<..<<<<<<<.<<<<..<<<<..>>>>..>>>>.>>>>>>>...<<<....>>>......>>>>>.>>..>>>>>...<.<.....>.>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<.........>>>>>....<<..[.(((.>>...>>>>>>>...<<<<<<<<......>>>>>>>>..<<<....>>>.>>)))]......<<<<<<.<<<...>>>>>.>>>>>>>>>..........>>>>..]]>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>..>>.......<<<<<.<<<<<<..<<<.<<<<<......>>>>>...>>>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..>>>.>>>.]]...<<<....<<<<.<<<<<<..................>>>>>><.<<<...<<<<...<<<<.<<<<.]]...>>>>.>>>>...>>>>.>>>.><<<<....<<<<<...........>>>>>....>>>>>>>>....>>>...<<<<<.<<<<.......>>>>....<<<<<<<<<<<<<....<<<<<..<<<..<<<...>>>.>>>..>>>>>...>>>>>>.>>>>>>>...>>>>>.. ...((((((((((.....(((..((((((((.(.(......((((((.[[.....)))....((((((..((.]].)).....))))))...))).....((((.....)))))....(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........((((((....)))))....).......((((((((((...((((.........))))[[(...).(((.....]])))...)))))))))).........)....(((((((........)))))))....(((((..[[[[[.)))))..)))......)..)))))).))...............((....))....)).).....)))))))))).(((((.....)))))[((((........))))((((((..(.((((.((((((((..(((..(((((.....)))))..)))...((....)).....)))))))).))))..((.(...((((.((.....(((((((((.(((((...(((((((....)))))))...)[))))..(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))).((((((....(((((....)))))((((((..(((((.(((((((.....(((....(.(((...(((....)))..))).)...)).).....)))))..)))))..))..)))).))..((.(((((((.....))))))).))....(((......)))...(((((((...(((.[[...(((((((.....(......((.(((((((((((...)))))))))))))..........]]..)...))))))))))...))))))).........))))))(.((((((((((......(.((((((....)))))).)...))))))))))..).....))))))((.....((.....((((((......)))))).(((.....((((..((..(((((((....))))))....[[(((.((...((..((((......))))..))....))...(((((........)))))]]((((((((((..(((....)))....(((.(((((...((((.((((..((((((((((((...{{..))))))((..((.....((((((((.....(((.....))).....))))))))....))..))((((((....))))))))))))...)))).))))(...)....))))))))...)))))))))).))).)))..((......)).)))).((((.....))))..)))....(......(((((((.((..(....(.......(((((....(.{..).....)))))((((((....))))))(...).......(((((((((.].((.........))...(((((((........))))))).}.(((.(((..(((((((...((.....((........)).....)).)))))..)))))(((((.........)))))........((..........((((((.....))))))..)..)....)))....)).))))))).)..))).)))))))...)..))....)).{..(((((.....]}.)))))..((.(((..(((.((......((((.((((((..(((((.((.(((((..(((((((.((....(((....)))....)).)))))))...(((....)))......))))).))..)))))..(((......[)).)((((((..........]))))))(.((...(((((((.(.(((((....(..).)))))...).(..[.[[[.)....)))))))...(((((((((....)))))))))..(((....))).))]]].].....((((((..((...]]]]].)).))))))....).....))))..)))))).......(..(.(..(((((...((.......))...)))))....))...)........((((.((((((..(((.(((((......)))))...))).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).))).))...(((....(((..((((((.......(....).....))))))(.(((...((((...((((.(((((}}..))))).))))...)))).))).)((((....((((.............))))....)))).)))....)))...(((((.((((.......))))..(.(((((((((((((....(((((..((....((...))...))..)))))...)))))).))))))))..))))).. Spraguea lophii ribosome dimer; RNA 28S 8p60 L70 119 14.3 RF00001 URS00026177A4_1358809 37709902 0003735 0005840 1358809 aguuacggccauaucuacugaaaaacaccggaucccguccgaucuccgaaguuaagccaauaagagccaugcgaguauuaaggugggcgacuacuugagaaagcguggugcuguaguuu <<<<<<<<<....<<<<.<<......<<<<<..............>>>..>>.....>>.>>.>><<<<<<<.....<<<<<..<<....>>.>>>>>....>>>>>>>>>>>>>>>>. ((.((((((....((((.((......((((((...(....)...))))..)).....)).)).))((((((......(((((..((....)).))))).....)))))))))))).)). Spraguea lophii ribosome dimer; RNA 5S 8p60 S60 1354 14.3 RF02542 URS000261779A_1358809 37709902 0003735 0005840 1358809 accagguugauucugccugacguggaugcuagucucauagauuuagccaugcauguguaagcgaagcgauuagugaagcggcggaaggcucaguaacgggcgaguauuuaaucucuagaaccggacaaccucaggaaacagaggggaaaacggaguaagagcauguguuagcaugugaugagaacaacagugcaggagaguaagaagccaucccaucaguuaguaaguaggguaagggccuauuuagacguagacggguacgggggauuaggguuugauuccggagagggagccugagagacggcuaccagguccaaggacagcagcaggcgcgaaaauuaccgaagccuccaagagggcgguagugaagagacgugaaaacaaguguguguaaaaaccacaugaguaacuggaggucaaggcuggugccagcauccgcgguaauaccagcuccaggagugucuaugaugauugcugcgauuaaaagguccguagucgaagaacaguacuuguuuguaauguggcuuaucgagagccgaauagaacgagaagaguucagaguaaggagcgaaggagggcuagauuauugagcagcgagaggugaaauuugaugaccugcuuaggaguaacagaggcgaaagcgcuagucaagaacgaauccgaugaucaaggacguaggcuggaggaucgaagacgauuagagaccguaguaguuccagcaguaaacgaugccuacgcuguugugguuaugagcacggcagaagagaaaucuaguagggcuuuggggagaguacgcgcgcaagcgauaaauuuaaaggaaauugacggaagaacaccacaaggaguggagugugcggcuuaauuugacucaacgcgggacagcuuaccauacccgauggccgugugagcguaguacgcgauaggucagagaguggugcauggccguuaacgacgaguggggugaccuuuggguuaaguccgcgaaguagugagaucccuaggauacgaaaguuaucgacagguguuaaaaacacaggaaggaaggggcaagaacaggucagugaugcccuuagaugguaugggcugcacgcgcacuacaguggucacagcagaaacaaauagaaguaaaugugaucgagagggaaugagcacuguaaugugcacaggaacgaggaauugcuaguaaucguuaucucauuaagaagcgaugaaugugucccuguucuuuguacacaccgcccgucguuaucgaagauggaaccaggugcgaacaagugaaagcgagugagugcaggguucuagaucugauacaagucguaacaaggcagcuguaggagaaccuguagcuggauca ..<<<<<.[.(((.>>>>>.<<<<<<<<<..<<<<<.<.......<<<.<<<..<<....<<...<<.....>>...>>.>>......<<.......<<<<.....<<...<<<<<.<..<<<.....<<<<.<....>.>>>>......>>>....<..<<<<<<....>>>>>>..>....<<....>>.>.>>>>>..>>...>>>.><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>..<<<<..>>>>....>>>>>>.........<<<....<<<<...>>>>..>>>...>..>>>>>..........<<<<<.........>>>>>......<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<...<<<<....<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>....>>>>.......<<<.<<......<<<<<<..<.<<<<<<<<...<<<......>>>......>>>>>>>>..>........<<....>>.>>>>>>.....>>..>>>...>>>...>>>>..<.<<<<<<<...<....<<<.........>>>....>>>>>>>>..>.......<<<.<<.<<<<<<<<.<<..>>.>>>>>>>>..<<..))>>..>>..>>>.>>>.<<<.......<<<....>>>.....>>>....))).]<<<<<.<<<<<<<..<<..<.<<<..<<<<<<<<<<......<<........>>..........<<<<<<<...<<<<<......<<<<...>>>>....>>>>>..<<<.<<<..<<.<<<<<<....<<.<..<<<....>>>...<<......>>......>.>>....<<<<..<..<<<....>>.>.>.....<<<<.....>>>>.........>>>>....>>>.>>>.....>>>>>>>>....>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....................>>>>>>>.........<<.<<<<......>>>>.>>..........>>>.>.....<<<<<..<<.......>>.>>>>>......>>...>>>>>>>>>>.>>.......<<.<..<<<<<.<...<<<<<<..<<<<..<<..<<....>>..>>..>>>>..>>>>>>...>.>>>>>...>.>>.........<<<<<<<<<....>>>>>>>>>...... ..((((..[.[[[..)))).(((((((((..(((((.(((.....(((.(((..((....((...((.....))...)).))......(((.......(((...(.((...(((((.(..(((.....((((.(....).))))......)))....(..((((((....))))))..).....(....)..).)))))..)))..)))..(((....(((..(((.((((.......)))).))))))......)))..(((.((((....))))....)))))).((.(((..........))).))..(((....)))....)))))).).....(.(((...(((((...)))).))))).))..)))))..........(((((.........)))))......((((([[....(.((((.....((..]])).......))))))))))..)))))))))..........((([[...(.((((...(((...((((....(((((((......((((((.....))))))....)))))))....))))......((((.((......(((((((....(((((((...((........))......)))))))....).......((....)).)))))).....))..)))..))))...))))....((((((....(....(((.........)))....).))))))......{...(((.((.((((((((.(....).))))))))..((..]]))..))..))))))).(((.......(((....))).....)))....]]].](((((.(((((((..((..(.(((..((((((((((......((........))..........(((((((...(((((......((((...))))....)))))...((.(((...(.((((((....(..(.((((....)))...((......))....).)..).....((.(.(...((....))...)..(..((((.....)))).....)..).)).....))).))).....).))))).....)))))))...)).)))))))).(...(((((((.....................)))))))....(....((.((((......)))).))....)..)..))).).....((((((.((.......))))))))......))...)))))))))).))..(.(..((.(..(((((.(..(((((((..((((..((..((....))..))..))))..)))))))..).)))))...).))...)..)..(((((((((....)))))))))}..... Spraguea lophii ribosome dimer; RNA 16S 8p60 K50 2499 14.3 RF02543 URS00026177A1_1358809 37709902 0003735 0005840 1358809 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....<<<<<<<<<......((..((<<<<<<...<......<<<<<<.((.....>>>....<<<<<<..<..))..>.....>>>>>>...>>>.....<<<<<...>>>>>>....<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..<<<...........<<<<<<..>>>>>>............<<<<<<<<<<...<<<<.........>>>>((......<<<.....))>>>...>>>>>>>>>>..............<<<<<<<........>>>>>>>....<<<<<..<<<<<.>>>>>..>>>.........>>>>>>.))...............<<....>>....)).......>>>>>>>>>..<<<<<.....>>>>>.<<<<........>>>><<<<<<....<<<<.<<<<<<<<..<<<..<<<<<.....>>>>>..>>>...<<....>>.....>>>>>>>>.>>>>..<<.<..<<<<<.<<.....<<<<<<<<<<<<<<....<<<<<<<....>>>>>>>.....>>>>>.<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<..<<<<<.<<<<<<<.....<<<......<<<...<<<<..>>>>..>>>.....>>.>.....>>>>>..>>>>>..>>..>>>>.>>..<<.<<<<<<<.....>>>>>>>.>>....<<<......>>>...<<<<<<<...<<<.((...<<<<<<<.....<......<<.<<<<<<<<<<<...>>>>>>>>>>>>>..........))..>...>>>>>>>>>>...>>>>>>>.........>>>>>><.<<<<<<<<<<......<.<<<<<<....>>>>>>.>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<......>>>>>>.<<<.....<<<<..<<...<<<<<<....>>>>>>....((<<<<<<...<<..<<<<......>>>>..>>....>>...<<<<<........>>>>>))<<<<<<<<<<..<<<....>>>....<<<.<<<<<...<<<<.<<<<..<<<<<<<<<<<<...[[..>>>>>><<..<<<..<.<<<<<<<<.....<<<<...>>>>.....>>>>>>>>.>.>>>..>><<<<<<....>>>>>>>>>>>>...>>>>.>>>>.........>>>>>>>>...>>>>>>>>>>>>>>..>>..<<......>>.>>>>.<<<<.....>>>>..>>>....<<.....<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<....>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<........>>>>>>>..<<<..<<<..<<<<<<<.<.<<.....<<........>>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>.....>>.>..>>.>>>>>>>..>..>>.>>>>>>>..>>..>>....>>....<<<<<........>>>>>..[[.<<<..<<<.[[......<<<<.[[<<<<..<<<<<.<<.<<<<<..<<<<<<<.<<<<..<<<<..>>>>..>>>>.>>>>>>>...<<<....>>>......>>>>>.>>..>>>>>...<.<.....>.>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<.........>>>>>....<<..[.(((.>>...>>>>>>>...<<<<<<<<......>>>>>>>>..<<<....>>>.>>)))]......<<<<<<.<<<...>>>>>.>>>>>>>>>..........>>>>..]]>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>..>>.......<<<<<.<<<<<<..<<<.<<<<<......>>>>>...>>>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..>>>.>>>.]]...<<<....<<<<.<<<<<<..................>>>>>><.<<<...<<<<...<<<<.<<<<.]]...>>>>.>>>>...>>>>.>>>.><<<<....<<<<<...........>>>>>....>>>>>>>>....>>>...<<<<<.<<<<.......>>>>....<<<<<<<<<<<<<....<<<<<..<<<..<<<...>>>.>>>..>>>>>...>>>>>>.>>>>>>>...>>>>>.. ...((((((((((.....(((..((((((((.(.(......((((((.[[.....)))....((((((..((.]].)).....))))))...))).....((((.....)))))....(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........((((((....)))))....).......((((((((((...((((.........))))[[(...).(((.....]])))...)))))))))).........)....(((((((........)))))))....(((((..[[[[[.)))))..)))......)..)))))).))...............((....))....)).).....)))))))))).(((((.....)))))[((((........))))((((((..(.((((.((((((((..(((..(((((.....)))))..)))...((....)).....)))))))).))))..((.(...((((.((.....(((((((((.(((((...(((((((....)))))))...)[))))..(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))).((((((....(((((....)))))((((((..(((((.(((((((.....(((....(.(((...(((....)))..))).)...)).).....)))))..)))))..))..)))).))..((.(((((((.....))))))).))....(((......)))...(((((((...(((.[[...(((((((.....(......((.(((((((((((...)))))))))))))..........]]..)...))))))))))...))))))).........))))))(.((((((((((......(.((((((....)))))).)...))))))))))..).....))))))((.....((.....((((((......)))))).(((.....((((..((..(((((((....))))))....[[(((.((...((..((((......))))..))....))...(((((........)))))]]((((((((((..(((....)))....(((.(((((...((((.((((..((((((((((((...{{..))))))((..((.....((((((((.....(((.....))).....))))))))....))..))((((((....))))))))))))...)))).))))(...)....))))))))...)))))))))).))).)))..((......)).)))).((((.....))))..)))....(......(((((((.((..(....(.......(((((....(.{..).....)))))((((((....))))))(...).......(((((((((.].((.........))...(((((((........))))))).}.(((.(((..(((((((...((.....((........)).....)).)))))..)))))(((((.........)))))........((..........((((((.....))))))..)..)....)))....)).))))))).)..))).)))))))...)..))....)).{..(((((.....]}.)))))..((.(((..(((.((......((((.((((((..(((((.((.(((((..(((((((.((....(((....)))....)).)))))))...(((....)))......))))).))..)))))..(((......[)).)((((((..........]))))))(.((...(((((((.(.(((((....(..).)))))...).(..[.[[[.)....)))))))...(((((((((....)))))))))..(((....))).))]]].].....((((((..((...]]]]].)).))))))....).....))))..)))))).......(..(.(..(((((...((.......))...)))))....))...)........((((.((((((..(((.(((((......)))))...))).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).))).))...(((....(((..((((((.......(....).....))))))(.(((...((((...((((.(((((}}..))))).))))...)))).))).)((((....((((.............))))....)))).)))....)))...(((((.((((.......))))..(.(((((((((((((....(((((..((....((...))...))..)))))...)))))).))))))))..))))).. Spraguea lophii ribosome dimer; RNA 28S 8p60 K70 119 14.3 RF00001 URS00026177A4_1358809 37709902 0003735 0005840 1358809 aguuacggccauaucuacugaaaaacaccggaucccguccgaucuccgaaguuaagccaauaagagccaugcgaguauuaaggugggcgacuacuugagaaagcguggugcuguaguuu <<<<<<<<<....<<<<.<<......<<<<<..............>>>..>>.....>>.>>.>><<<<<<<.....<<<<<..<<....>>.>>>>>....>>>>>>>>>>>>>>>>. ((.((((((....((((.((......((((((...(....)...))))..)).....)).)).))((((((......(((((..((....)).))))).....)))))))))))).)). Spraguea lophii ribosome dimer; RNA 5S 8p60 R60 1354 14.3 RF02542 URS000261779A_1358809 37709902 0003735 0005840 1358809 accagguugauucugccugacguggaugcuagucucauagauuuagccaugcauguguaagcgaagcgauuagugaagcggcggaaggcucaguaacgggcgaguauuuaaucucuagaaccggacaaccucaggaaacagaggggaaaacggaguaagagcauguguuagcaugugaugagaacaacagugcaggagaguaagaagccaucccaucaguuaguaaguaggguaagggccuauuuagacguagacggguacgggggauuaggguuugauuccggagagggagccugagagacggcuaccagguccaaggacagcagcaggcgcgaaaauuaccgaagccuccaagagggcgguagugaagagacgugaaaacaaguguguguaaaaaccacaugaguaacuggaggucaaggcuggugccagcauccgcgguaauaccagcuccaggagugucuaugaugauugcugcgauuaaaagguccguagucgaagaacaguacuuguuuguaauguggcuuaucgagagccgaauagaacgagaagaguucagaguaaggagcgaaggagggcuagauuauugagcagcgagaggugaaauuugaugaccugcuuaggaguaacagaggcgaaagcgcuagucaagaacgaauccgaugaucaaggacguaggcuggaggaucgaagacgauuagagaccguaguaguuccagcaguaaacgaugccuacgcuguugugguuaugagcacggcagaagagaaaucuaguagggcuuuggggagaguacgcgcgcaagcgauaaauuuaaaggaaauugacggaagaacaccacaaggaguggagugugcggcuuaauuugacucaacgcgggacagcuuaccauacccgauggccgugugagcguaguacgcgauaggucagagaguggugcauggccguuaacgacgaguggggugaccuuuggguuaaguccgcgaaguagugagaucccuaggauacgaaaguuaucgacagguguuaaaaacacaggaaggaaggggcaagaacaggucagugaugcccuuagaugguaugggcugcacgcgcacuacaguggucacagcagaaacaaauagaaguaaaugugaucgagagggaaugagcacuguaaugugcacaggaacgaggaauugcuaguaaucguuaucucauuaagaagcgaugaaugugucccuguucuuuguacacaccgcccgucguuaucgaagauggaaccaggugcgaacaagugaaagcgagugagugcaggguucuagaucugauacaagucguaacaaggcagcuguaggagaaccuguagcuggauca ..<<<<<.[.(((.>>>>>.<<<<<<<<<..<<<<<.<.......<<<.<<<..<<....<<...<<.....>>...>>.>>......<<.......<<<<.....<<...<<<<<.<..<<<.....<<<<.<....>.>>>>......>>>....<..<<<<<<....>>>>>>..>....<<....>>.>.>>>>>..>>...>>>.><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>..<<<<..>>>>....>>>>>>.........<<<....<<<<...>>>>..>>>...>..>>>>>..........<<<<<.........>>>>>......<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<...<<<<....<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>....>>>>.......<<<.<<......<<<<<<..<.<<<<<<<<...<<<......>>>......>>>>>>>>..>........<<....>>.>>>>>>.....>>..>>>...>>>...>>>>..<.<<<<<<<...<....<<<.........>>>....>>>>>>>>..>.......<<<.<<.<<<<<<<<.<<..>>.>>>>>>>>..<<..))>>..>>..>>>.>>>.<<<.......<<<....>>>.....>>>....))).]<<<<<.<<<<<<<..<<..<.<<<..<<<<<<<<<<......<<........>>..........<<<<<<<...<<<<<......<<<<...>>>>....>>>>>..<<<.<<<..<<.<<<<<<....<<.<..<<<....>>>...<<......>>......>.>>....<<<<..<..<<<....>>.>.>.....<<<<.....>>>>.........>>>>....>>>.>>>.....>>>>>>>>....>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....................>>>>>>>.........<<.<<<<......>>>>.>>..........>>>.>.....<<<<<..<<.......>>.>>>>>......>>...>>>>>>>>>>.>>.......<<.<..<<<<<.<...<<<<<<..<<<<..<<..<<....>>..>>..>>>>..>>>>>>...>.>>>>>...>.>>.........<<<<<<<<<....>>>>>>>>>...... ..((((..[.[[[..)))).(((((((((..(((((.(((.....(((.(((..((....((...((.....))...)).))......(((.......(((...(.((...(((((.(..(((.....((((.(....).))))......)))....(..((((((....))))))..).....(....)..).)))))..)))..)))..(((....(((..(((.((((.......)))).))))))......)))..(((.((((....))))....)))))).((.(((..........))).))..(((....)))....)))))).).....(.(((...(((((...)))).))))).))..)))))..........(((((.........)))))......((((([[....(.((((.....((..]])).......))))))))))..)))))))))..........((([[...(.((((...(((...((((....(((((((......((((((.....))))))....)))))))....))))......((((.((......(((((((....(((((((...((........))......)))))))....).......((....)).)))))).....))..)))..))))...))))....((((((....(....(((.........)))....).))))))......{...(((.((.((((((((.(....).))))))))..((..]]))..))..))))))).(((.......(((....))).....)))....]]].](((((.(((((((..((..(.(((..((((((((((......((........))..........(((((((...(((((......((((...))))....)))))...((.(((...(.((((((....(..(.((((....)))...((......))....).)..).....((.(.(...((....))...)..(..((((.....)))).....)..).)).....))).))).....).))))).....)))))))...)).)))))))).(...(((((((.....................)))))))....(....((.((((......)))).))....)..)..))).).....((((((.((.......))))))))......))...)))))))))).))..(.(..((.(..(((((.(..(((((((..((((..((..((....))..))..))))..)))))))..).)))))...).))...)..)..(((((((((....)))))))))}..... Spraguea lophii ribosome dimer; RNA 16S 8p6p 3 24 3.2 39668257 272634 ggccguaacuauaacgguccuaag <<<<<<.......>>>>>>..... (((((.........)))))..... Mycoplasma pneumoniae small ribosomal subunit in chloramphenicol-treated cells; 23S ribosomal RNA 8p6p 5 1507 3.2 RF00177,RF01959,RF02542,RF01960 39668257 0003735 0005840 272634 ucugagaguuugauccuggcucaggauuaacgcuggcggcaugccuaauacaugcaagucgaucgaaaguaguaauacuuuagaggcgaacgggugaguaacacguauccaaucuaccuuauaaugggggauaacuaguugaaagacuagcuaauaccgcauaagaacuuugguucgcaugaaucaaaguugaaaggaccugcaaggguucguuauuugaugagggugcgccauaucagcuaguuggugggguaacggccuaccaaggcaaugacguguagcuaugcugagaaguagaauagccacaaugggacugagacacggcccauacuccuacgggaggcagcaguagggaauuuuucacaaugagcgaaagcuugauggagcaaugccgcgugaacgaugaaggucuuuaagauuguaaaguucuuuuauuugggaagaaugacuuuagcagguaauggcuagaguuugacuguaccauuuugaauaagugacgacuaacuaugugccagcagucncgguaauacauaggucgcaagcguuauccggauuuauugggcguaaagcaagcgcaggcggauugaaaagucugguguuaaaggcagcugcuuaacaguuguaugcauuggaaacuauuaaucuagagugugguagggaguuuuggaauuucauguggagcggugaaaugcguagauauaugaaggaacaccaguggcgaaggcgaaaacuuaggccauuacugacgcuuaggcuugaaaguguggggagcaaauaggauuagauacccuaguaguccacaccguaaacgauagauacuagcugucggggcgauccccucgguagugaaguuaacacauuaaguaucucgccuggguaguacauucgcaagaaugaaacucaaacggaauugacggggacccgcacaagugguggagcauguugcuuaauucgacgguacacgaaaaaccuuaccuagacuugacauccuuggcaaaauuauggaaacauaauggagguuaaccgagugacagguggugcaugguugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuuaucguuaguuacauugucuagcgagacugcuaaugcaaauuggaggaaggaagggaugacgucaaaucaucaugccccuuaugucuagggcugcaaacgugcuacaauggccaauacaaacagucgccagcuuguaaaagugagcaaaucuguaaaguuggucucaguucggauugagggcugcaauucguccucaugaagucggaaucacuaguaaucgcgaaucagcuaugucgcggugaauacguucucgggucuuguacacacngnccgucaaacuaugaaagcugguaauauuuaaaaacguguugcuaaccauuaggaagcgcaugucaaggauagcaccggugauuggaguuaagucguaacaagguaccccuacgagnncguggggguggaucacc .....<<<<..[.(((..>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<<<<<....>>>>>>.>>>>>......<<........<<<<<<<..<<...<..<<<<<<.<<.....<<<<<<....>>>>>>......>>.>.....<<<<<<<<<<<....>>>>>>>>>>>....<<<<<<....>>>>>>>>>>>..>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<...>>>>>.....>>>>...<<..<<<.......<<<<<<<<<........>>>>>>>>.>.......>>>...>>.....<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<..<<<<<<<<<<.....<<<<<<<.....>>>>>>>..>>>>>>>>..>>.>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<<..<<<......>>>.....>>>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<......>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<.....<<<<<....>>>>>...>>>....))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<.....<<<<<<....>>>>>>..........>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<.........>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<..<<<<<....<<<<<<.<<<..<<....>>.>>>>>>>>>...>>>>>..>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>........ .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((....)))))).)))))......(((.......(((((((..((...(..((((((.((.....(((((......)))))......)).).....(((((((((.(....).)))))))))....((((((....)))))))))))..)..))))))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((....((((....))))..)))).)).))))))..((((......((((.....)))).....))))....(..(((...(....(((.((((........)))).)))....)....)))...)......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.((((((..((((((((((.....(((((((.....)))))))..))))))))..)).))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((......))))))))))...((..]])).....)))))))))).(((.......(((....))).....)))....]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((.((....((((((....)))))).........)).)).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((.........)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..(((.((((....))))).))....)))....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((..........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((..(((((....((((((.(((..((....)).)))))))))...)))))..))))))..))).))))..).))...)..)..(((((((((....)))))))))}....... Mycoplasma pneumoniae small ribosomal subunit in chloramphenicol-treated cells; 16S ribosomal RNA 8p6p 7 30 3.2 39668257 272634 gguguacauaucucccugucacggaggggu .<<<<>>>>.<<<<<.......>>>>>... ..((()))...((((.......)))).... Mycoplasma pneumoniae small ribosomal subunit in chloramphenicol-treated cells; tRNA-Asp (P-site) 8p6p 8 30 3.2 39668257 272634 agcucgagcaaaugacucuuaaucauuggg .<<<<>>>>.<<<<<.......>>>>>... .(((()))).(((((.......)))))... Mycoplasma pneumoniae small ribosomal subunit in chloramphenicol-treated cells; tRNA-Lys (A-site) 8p6p Y 21 3.2 39668257 272634 cugcugauaaggucuucaaaa ..................... ..................... Mycoplasma pneumoniae small ribosomal subunit in chloramphenicol-treated cells; mRNA 8p7x 3 2893 3.03 RF02540,RF02541,RF02543,RF00002 39668257 0003735 0005840 272634 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Mycoplasma pneumoniae 70S ribosome in chloramphenicol-treated cells; 23S ribosomal RNA 8p7x 4 108 3.03 RF00001 39668257 0003735 0005840 272634 uuuggugcccaugucgcuguggaaacaccugguuccauuucgaacccagcaguuaagcacaguggagccgaauguagcuguuucagugagaauaggaaagcaccaagc <<<<<<<<.....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<..<..<.<<<<...>>>>...>.>.>>...>>>>>>>>. .(((((((.....((((((((.....((((((...(.....)...))))..))....)))))).)).((.......((((...)))).......))...))))))).. Mycoplasma pneumoniae 70S ribosome in chloramphenicol-treated cells; 5S ribosomal RNA 8p7x 5 1507 3.03 RF00177,RF01959,RF02542,RF01960 39668257 0003735 0005840 272634 ucugagaguuugauccuggcucaggauuaacgcuggcggcaugccuaauacaugcaagucgaucgaaaguaguaauacuuuagaggcgaacgggugaguaacacguauccaaucuaccuuauaaugggggauaacuaguugaaagacuagcuaauaccgcauaagaacuuugguucgcaugaaucaaaguugaaaggaccugcaaggguucguuauuugaugagggugcgccauaucagcuaguuggugggguaacggccuaccaaggcaaugacguguagcuaugcugagaaguagaauagccacaaugggacugagacacggcccauacuccuacgggaggcagcaguagggaauuuuucacaaugagcgaaagcuugauggagcaaugccgcgugaacgaugaaggucuuuaagauuguaaaguucuuuuauuugggaagaaugacuuuagcagguaauggcuagaguuugacuguaccauuuugaauaagugacgacuaacuaugugccagcagucncgguaauacauaggucgcaagcguuauccggauuuauugggcguaaagcaagcgcaggcggauugaaaagucugguguuaaaggcagcugcuuaacaguuguaugcauuggaaacuauuaaucuagagugugguagggaguuuuggaauuucauguggagcggugaaaugcguagauauaugaaggaacaccaguggcgaaggcgaaaacuuaggccauuacugacgcuuaggcuugaaaguguggggagcaaauaggauuagauacccuaguaguccacaccguaaacgauagauacuagcugucggggcgauccccucgguagugaaguuaacacauuaaguaucucgccuggguaguacauucgcaagaaugaaacucaaacggaauugacggggacccgcacaagugguggagcauguugcuuaauucgacgguacacgaaaaaccuuaccuagacuugacauccuuggcaaaauuauggaaacauaauggagguuaaccgagugacagguggugcaugguugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuuaucguuaguuacauugucuagcgagacugcuaaugcaaauuggaggaaggaagggaugacgucaaaucaucaugccccuuaugucuagggcugcaaacgugcuacaauggccaauacaaacagucgccagcuuguaaaagugagcaaaucuguaaaguuggucucaguucggauugagggcugcaauucguccucaugaagucggaaucacuaguaaucgcgaaucagcuaugucgcggugaauacguucucgggucuuguacacacngnccgucaaacuaugaaagcugguaauauuuaaaaacguguugcuaaccauuaggaagcgcaugucaaggauagcaccggugauuggaguuaagucguaacaagguaccccuacgagnncguggggguggaucacc .....<<<<..[.(((..>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<....>>>>>>.>>>>>......<<........<<<<<<<..<<...<..<<<<<<.<<.....<<<<<<....>>>>>>......>>.>.....<<<<<<<<<<<....>>>>>>>>>>>....<<<<<<....>>>>>>>>>>>..>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<...>>>>>.....>>>>...<<..<<<.......<<<<<<<<<........>>>>>>>>.>.......>>>...>>.....<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<..<<<<<<<<<<.....<<<<<<<.....>>>>>>>..>>>>>>>>..>>.>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<<..<<<......>>>.....>>>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<......>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<.....<<<<<....>>>>>...>>>....))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<.....<<<<<<....>>>>>>..........>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<.........>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>....>>>>>>>......<..<.<<<<<<<........>>>>>>>>...>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<..<<<<<....<<<<<<.<<<..<<....>>.>>>>>>>>>...>>>>>..>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>........ .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((....)))))).)))))......(((.......(((((((..((...(..((((((.((.....((((((....))))))......)).).....(((((((((.(....).)))))))))....((((((....)))))))))))..)..))))))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((.....)))).....))))....(..(((...(....(((.((((........)))).)))....)....)))...)......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.((((((..((((((((((.....(((((((.....)))))))..))))))))..)).))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((......))))))))))...((..]])).....)))))))))).(((.......(((....))).....)))....]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((.((....((((((....)))))).........)).)).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((.........)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..(((.((((....))))).))....)))....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((..........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((..(((((....((((((.(((..((....)).)))))))))...)))))..))))))..))).))))..).))...)..)..(((((((((....)))))))))}....... Mycoplasma pneumoniae 70S ribosome in chloramphenicol-treated cells; 16S ribosomal RNA 8p7x 6 76 3.03 RF00005 39668257 0030533 272634 ggggauguagcucaacugauagagcaccugauuugcacucaggagguugaggguuugagacccuucaucuccacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<<.....>>>>>>>>>>>>>.... ((.((((..((((.....[..)))).(((((.......)))))......((((..]....)))).)))).)).... Mycoplasma pneumoniae 70S ribosome in chloramphenicol-treated cells; tRNA-Ala (E-site) 8p7x 7 75 3.03 RF00005 39668257 0030533 272634 gguuccaugguguaguggauaacauaucucccugucacggagggguugcggguucgauucccguuggaaccgcca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>....<<<<<.......>>>>>>>>>>>>.... (((((((...(((........)))...((((.......))))......((((.......)))).))))))).... Mycoplasma pneumoniae 70S ribosome in chloramphenicol-treated cells; tRNA-Asp (P-site) 8p7x 8 76 3.03 RF00005 39668257 0030533 272634 gcaucuuuagcucaguugguagagcaaaugacucuuaaucauugggucggggguucgagccccucaagaugcacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).(((((.......))))).....(.(((..]....))).)))))))).... Mycoplasma pneumoniae 70S ribosome in chloramphenicol-treated cells; tRNA-Lys (A-site) 8p7x Y 21 3.03 39668257 272634 cugccgauaaggucuucaaaa ..................... ..................... Mycoplasma pneumoniae 70S ribosome in chloramphenicol-treated cells; mRNA 8p7y 3 2893 3.7 RF02540,RF02541,RF02543,RF00002 39668257 0003735 0005840 272634 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Mycoplasma pneumoniae 70S ribosome with second S4 protein on large subunit; 23S ribosomal RNA 8p7y 4 108 3.7 RF00001 39668257 0003735 0005840 272634 uuuggugcccaugucgcuguggaaacaccugguuccauuucgaacccagcaguuaagcacaguggagccgaauguagcuguuucagugagaauaggaaagcaccaagc <<<<<<<<.....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<..<..<.<<<<...>>>>...>.>.>>...>>>>>>>>. .(((((((.....((((((((.....((((((...(.....)...))))..))....)))))).)).((.......((((...)))).......))...))))))).. Mycoplasma pneumoniae 70S ribosome with second S4 protein on large subunit; 5S ribosomal RNA 8p7y 5 1507 3.7 RF00177,RF01959,RF02542,RF01960 39668257 0003735 0005840 272634 ucugagaguuugauccuggcucaggauuaacgcuggcggcaugccuaauacaugcaagucgaucgaaaguaguaauacuuuagaggcgaacgggugaguaacacguauccaaucuaccuuauaaugggggauaacuaguugaaagacuagcuaauaccgcauaagaacuuugguucgcaugaaucaaaguugaaaggaccugcaaggguucguuauuugaugagggugcgccauaucagcuaguuggugggguaacggccuaccaaggcaaugacguguagcuaugcugagaaguagaauagccacaaugggacugagacacggcccauacuccuacgggaggcagcaguagggaauuuuucacaaugagcgaaagcuugauggagcaaugccgcgugaacgaugaaggucuuuaagauuguaaaguucuuuuauuugggaagaaugacuuuagcagguaauggcuagaguuugacuguaccauuuugaauaagugacgacuaacuaugugccagcagucncgguaauacauaggucgcaagcguuauccggauuuauugggcguaaagcaagcgcaggcggauugaaaagucugguguuaaaggcagcugcuuaacaguuguaugcauuggaaacuauuaaucuagagugugguagggaguuuuggaauuucauguggagcggugaaaugcguagauauaugaaggaacaccaguggcgaaggcgaaaacuuaggccauuacugacgcuuaggcuugaaaguguggggagcaaauaggauuagauacccuaguaguccacaccguaaacgauagauacuagcugucggggcgauccccucgguagugaaguuaacacauuaaguaucucgccuggguaguacauucgcaagaaugaaacucaaacggaauugacggggacccgcacaagugguggagcauguugcuuaauucgacgguacacgaaaaaccuuaccuagacuugacauccuuggcaaaauuauggaaacauaauggagguuaaccgagugacagguggugcaugguugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuuaucguuaguuacauugucuagcgagacugcuaaugcaaauuggaggaaggaagggaugacgucaaaucaucaugccccuuaugucuagggcugcaaacgugcuacaauggccaauacaaacagucgccagcuuguaaaagugagcaaaucuguaaaguuggucucaguucggauugagggcugcaauucguccucaugaagucggaaucacuaguaaucgcgaaucagcuaugucgcggugaauacguucucgggucuuguacacacngnccgucaaacuaugaaagcugguaauauuuaaaaacguguugcuaaccauuaggaagcgcaugucaaggauagcaccggugauuggaguuaagucguaacaagguaccccuacgagnncguggggguggaucacc .....<<<<..[.(((..>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<....>>>>>>.>>>>>......<<........<<<<<<<..<<...<..<<<<<<.<<.....<<<<<<....>>>>>>......>>.>.....<<<<<<<<<<<....>>>>>>>>>>>....<<<<<<....>>>>>>>>>>>..>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<...>>>>>.....>>>>...<<..<<<.......<<<<<<<<<........>>>>>>>>.>.......>>>...>>.....<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<..<<<<<<<<<<.....<<<<<<<.....>>>>>>>..>>>>>>>>..>>.>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<<..<<<......>>>.....>>>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<......>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<.....<<<<<....>>>>>...>>>....))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<.....<<<<<<....>>>>>>..........>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<.........>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>....>>>>>>>......<..<.<<<<<<<........>>>>>>>>...>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<..<<<<<....<<<<<<.<<<..<<....>>.>>>>>>>>>...>>>>>..>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>........ .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((....)))))).)))))......(((.......(((((((..((...(..((((((.((.....((((((....))))))......)).).....(((((((((.(....).)))))))))....((((((....)))))))))))..)..))))))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((.....)))).....))))....(..(((...(....(((.((((........)))).)))....)....)))...)......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.((((((..((((((((((.....(((((((.....)))))))..))))))))..)).))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((......))))))))))...((..]])).....)))))))))).(((.......(((....))).....)))....]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((.((....((((((....)))))).........)).)).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((.........)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..(((.((((....))))).))....)))....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((..........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((..(((((....((((((.(((..((....)).)))))))))...)))))..))))))..))).))))..).))...)..)..(((((((((....)))))))))}....... Mycoplasma pneumoniae 70S ribosome with second S4 protein on large subunit; 16S ribosomal RNA 8p7y 6 76 3.7 RF00005 39668257 0030533 272634 ggggauguagcucaacugauagagcaccugauuugcacucaggagguugaggguuugagacccuucaucuccacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<<.....>>>>>>>>>>>>>.... ((.((((..((((.....[..)))).(((((.......)))))......((((..]....)))).)))).)).... Mycoplasma pneumoniae 70S ribosome with second S4 protein on large subunit; tRNA-Ala (E-site) 8p7y 7 75 3.7 RF00005 39668257 0030533 272634 gguuccaugguguaguggauaacauaucucccugucacggagggguugcggguucgauucccguuggaaccgcca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>....<<<<<.......>>>>>>>>>>>>.... (((((((...(((........)))...((((.......))))......((((.......)))).))))))).... Mycoplasma pneumoniae 70S ribosome with second S4 protein on large subunit; tRNA-Asp (P-site) 8p7y 8 76 3.7 RF00005 39668257 0030533 272634 gcaucuuuagcucaguugguagagcaaaugacucuuaaucauugggucggggguucgagccccucaagaugcacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).(((((.......))))).....(.(((..]....))).)))))))).... Mycoplasma pneumoniae 70S ribosome with second S4 protein on large subunit; tRNA-Lys (A-site) 8p7y Y 21 3.7 39668257 272634 cugccgauaaggucuucaaaa ..................... ..................... Mycoplasma pneumoniae 70S ribosome with second S4 protein on large subunit; mRNA 8p8b 3 2893 2.9 RF02540,RF02541,RF02543,RF00002 39668257 0003735 0005840 272634 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Mycoplasma pneumoniae large ribosomal subunit in chloramphenicol-treated cells; 23S ribosomal RNA 8p8b 4 108 2.9 RF00001 39668257 0003735 0005840 272634 uuuggugcccaugucgcuguggaaacaccugguuccauuucgaacccagcaguuaagcacaguggagccgaauguagcuguuucagugagaauaggaaagcaccaagc <<<<<<<<.....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<..<..<.<<<<...>>>>...>.>.>>...>>>>>>>>. .(((((((.....((((((((.....((((((...(.....)...))))..))....)))))).)).((.......((((...)))).......))...))))))).. Mycoplasma pneumoniae large ribosomal subunit in chloramphenicol-treated cells; 5S ribosomal RNA 8p8b 5 32 2.9 39668257 272634 cngnccgucaaacuaguuaagucguaacaagg ..<..<<.<.<<<..>>>..>.>>...>.... (.(..((.(.(((())))..).))...)..). Mycoplasma pneumoniae large ribosomal subunit in chloramphenicol-treated cells; 16S ribosomal RNA 8p8b 7 75 2.9 RF00005 39668257 0030533 272634 gguuccaugguguaguggauaacauaucucccugucacggagggguugcggguucgauucccguuggaaccgcca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>....<<<<<.......>>>>>>>>>>>>.... (((((((...(((........)))...((((.......))))......((((.......)))).))))))).... Mycoplasma pneumoniae large ribosomal subunit in chloramphenicol-treated cells; tRNA-Asp (P-site) 8p8b 8 76 2.9 RF00005 39668257 0030533 272634 gcaucuuuagcucaguugguagagcaaaugacucuuaaucauugggucggggguucgagccccucaagaugcacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).(((((.......))))).....(.(((..]....))).)))))))).... Mycoplasma pneumoniae large ribosomal subunit in chloramphenicol-treated cells; tRNA-Lys (A-site) 8p8m A 3035 2.66 RF02543 39041433 0003735 0005840 4932 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........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<<.<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<......<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<......>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<....>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<......<..........<<<.<<<<<<<<<<..........>>>>>>>>>>>>>..........))).>....>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<.<<<.....>.>>.>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<.....<..>......>>>>><<.<<<<<<<<<<.....>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>.<.<<..<<<..<<<<<<.<...<<....<<<<<....>>>>.>...>>.>>>>>..>>>>>........<...........<<<<<.......>>>>>.....>.....>>.>..>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<...>>>...<<<<<.....<<<<....................<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>..>>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<.}}}..>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. 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Yeast 60S ribosomal subunit, RPL39 deletion; 25S rRNA 8p8m LD 158 2.66 RF00002 39041433 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Yeast 60S ribosomal subunit, RPL39 deletion; 5.8S rRNA 8p8m LE 121 2.66 RF00001 39041433 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Yeast 60S ribosomal subunit, RPL39 deletion; 5S rRNA 8p8n A 3043 2.15 RF02543 39041433,29872004 0003735 0005840 4932 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Mouse RPL39 integrated into the yeast 60S ribosomal subunit; 25S rRNA 8p8n LD 157 2.15 RF00002 39041433,29872004 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>.................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....))))))))).................... Mouse RPL39 integrated into the yeast 60S ribosomal subunit; 5.8S rRNA 8p8n LE 121 2.15 RF00001 39041433,29872004 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Mouse RPL39 integrated into the yeast 60S ribosomal subunit; 5S rRNA 8p8u A 3045 2.23 RF02543 39041433,29872004 0003735 0005840 4932 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........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<<.<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<......<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<......>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<....>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<......<..........<<<.<<<<<<<<<<..........>>>>>>>>>>>>>..........))).>....>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<..<<<.....>.>>..>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<..>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<...<<.....<<<<....>>>>.....>>.>>>>>..>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<...>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>..>>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((......((((.(....).)))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((........)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...(......).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((..........)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...((((((...((.....)).))))))....[[(((.((...((....(((....))).............((.....).).........))....))...(((((........)))))]]((((..(((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((((()))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((...)))....((((.....((((..((((........))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))....))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.............))))...)))).))))....)))))))).......(((((..(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).)))..)))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(((.((..)..).)))..)))))...)))....)))).)))))).))))).. Yeast 60S ribosomal subunit; 25S rRNA 8p8u LD 158 2.23 RF00002 39041433,29872004 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Yeast 60S ribosomal subunit; 5.8S rRNA 8p8u LE 121 2.23 RF00001 39041433,29872004 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Yeast 60S ribosomal subunit; 5S rRNA 8p8v 3 2893 8.7 RF02540,RF02541,RF02543,RF00002 39668257 0003735 0005840 272634 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<<<......<<<<.<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>....<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((....<<<<<......>>>>>......<<<<<<<<<.....<<...<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>..>>..>>>>>..>>>>.....<<<<<<<<<....>.>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<....>>>>..................>>>>>>.>>>>.......<<<<..<<<<......>>>>..>>>>...<<<........>>>.<<<<<<....<<<<<<<<<<<<<...<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<.<<........>>.>>>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<....<<<<<<<<<<.....<<<....<<..<<<<<...<<<<<<.....>>>>>.>...>>>>>..>>..>>.>.....>>>>>>>>>>...>>>>>>.>>..<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((...<<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>...........))).....>>>>>>>>>>...>>>>>>><<<<<<<....>>>>>>>....>>>>>>..<<<<<<<<<<......<<<<<.<<....>>.>>>>>...>>>>>>>>>>........>>>>>>.......<<...<<<<<<.......>>>>>><<<<....<<<<<.<<<..<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<<...<<<<..<<<<..<<<<<<<<<....(((...>>>>><<..<<<<<..<<<<<<<<<<<.<<.....>>>>>>>>>....>>>>..>>>>>...>><..<<....<<....>>.....>>...>>>>>....>>>>...>>>>........>>>>>..>>.....>>>>>>>>>>>>>>>.>>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<<...<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<......>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<..<<<<<<<.<<....>>..>>>>>>>..>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<.<<<<.....>>>>.>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>>>>>>>>...........<<<<<........>>>>>..<<<<<<<..(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<<.<<.<<<.<<<....<<...........<<<<<..<<.......<<<<<<<.....>.>>>>>>....>>.............>>>>>..>>....>>>.>>>.>>...<<<..<<<<<.....>>>>>.>>>....>>>>>>>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..))).>>>>>>>....<<<<<<<....<<<..<<<<<<<...............>>>>>>><<<<<<...<<<<...<<<<<<<<<<<.)))>>>>>>..>>>>>...>>>>.>>>>>>..<<<....<<<<<...........>>>>>....>>>.>>>........>>>>>>>..<<<<....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> 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Mycoplasma pneumoniae di-ribosome in chloramphenicol-treated cells (leading 70S); 23S ribosomal RNA 8p8v 4 108 8.7 RF00001 39668257 0003735 0005840 272634 uuuggugcccaugucgcuguggaaacaccugguuccauuucgaacccagcaguuaagcacaguggagccgaauguagcuguuucagugagaauaggaaagcaccaagc <<<<<<<<.....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<..<..<.<<<<...>>>>...>.>.>>...>>>>>>>>. .(((((((.....((((((((.....((((((...(.....)...))))..))....)))))).)).((.......((((...)))).......))...))))))).. Mycoplasma pneumoniae di-ribosome in chloramphenicol-treated cells (leading 70S); 5S ribosomal RNA 8p8v 5 1506 8.7 RF00177,RF01959,RF02542,RF01960 39668257 0003735 0005840 272634 ucugagaguuugauccuggcucaggauuaacgcuggcggcaugccuaauacaugcaagucgaucgaaaguaguaauacuuuagaggcgaacgggugaguaacacguauccaaucuaccuuauaaugggggauaacuaguugaaagacuagcuaauaccgcauaagaacuuugguucgcaugaaucaaaguugaaaggaccugcaaggguucguuauuugaugagggugcgccauaucagcuaguuggugggguaacggccuaccaaggcaaugacguguagcuaugcugagaaguagaauagccacaaugggacugagacacggcccauacuccuacgggaggcagcaguagggaauuuuucacaaugagcgaaagcuugauggagcaaugccgcgugaacgaugaaggucuuuaagauuguaaaguucuuuuauuugggaagaaugacuuuagcagguaauggcuagaguuugacuguaccauuuugaauaagugacgacuaacuaugugccagcagucncgguaauacauaggucgcaagcguuauccggauuuauugggcguaaagcaagcgcaggcggauugaaaagucugguguuaaaggcagcugcuuaacaguuguaugcauuggaaacuauuaaucuagagugugguagggaguuuuggaauuucauguggagcggugaaaugcguagauauaugaaggaacaccaguggcgaaggcgaaaacuuaggccauuacugacgcuuaggcuugaaaguguggggagcaaauaggauuagauacccuaguaguccacaccguaaacgauagauacuagcugucggggcgauccccucgguagugaaguuaacacauuaaguaucucgccuggguaguacauucgcaagaaugaaacucaaacggaauugacggggacccgcacaagugguggagcauguugcuuaauucgacgguacacgaaaaaccuuaccuagacuugacauccuuggcaaaauuauggaaacauaauggagguuaaccgagugacagguggugcaugguugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuuaucguuaguuacauugucuagcgagacugcuaaugcaaauuggaggaaggaagggaugacgucaaaucaucaugccccuuaugucuagggcugcaaacgugcuacaauggccaauacaaacagucgccagcuuguaaaagugagcaaaucuguaaaguuggucucaguucggauugagggcugcaauucguccucaugaagucggaaucacuaguaaucgcgaaucagcuaugucgcggugaauacguucucgggucuuguacacacngnccgucaaacuaugaaagcugguaauauuuaaaaacguguugcuaaccauuaggaagcgcaugucaaggauagcaccggugauuggaguuaagucguaacaagguaccccuacgagnncguggggguggaucac .....<<<<..[.(((..>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<....>>>>>>.>>>>>......<<........<<<<<<<..<<...<..<<<<<<.<<.....<<<<<<....>>>>>>......>>.>.....<<<<<<<<<<<....>>>>>>>>>>>....<<<<<<....>>>>>>>>>>>..>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<...>>>>>.....>>>>...<<..<<<........<<<<<<<<........>>>>>>>>.........>>>...>>.....<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<..<<<<<<<<<<.....<<<<<<<.....>>>>>>>..>>>>>>>>..>>.>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<<..<<<......>>>.....>>>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<......>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<.....<<<<<....>>>>>...>>>....))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<.....<<<<<<....>>>>>>..........>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<.........>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>....>>>>>>>......<..<.<<<<<<<........>>>>>>>>...>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<..<<<<<....<<<<<<.<<<..<<....>>.>>>>>>>>>...>>>>>..>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>....... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((....)))))).)))))......(((.......(((((((..((...(..((((((.((.....((((((....))))))......)).).....(((((((((.(....).)))))))))....((((((....)))))))))))..)..))))))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((.....)))).....)))).......(((...(....(((.((((........)))).)))....)....)))..........((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.((((((..((((((((((.....(((((((.....)))))))..))))))))..)).))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((......))))))))))...((..]])).....)))))))))).(((.......(((....))).....)))....]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((....((((((....)))))).........))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((.........)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....))))))))..)).)))))))).(...(((((((.....(((..(((.((((....))))).))....)))....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((..........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((..(((((....((((((.(((..((....)).)))))))))...)))))..))))))..))).))))..).))...)..)..(((((((((....)))))))))}...... Mycoplasma pneumoniae di-ribosome in chloramphenicol-treated cells (leading 70S); 16S ribosomal RNA 8p8v 6 76 8.7 RF00005 39668257 0030533 272634 ggggauguagcucaacugauagagcaccugauuugcacucaggagguugaggguuugagacccuucaucuccacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... ((.((((..((((........)))).(((((.......)))))......((((.......)))).)))).)).... Mycoplasma pneumoniae di-ribosome in chloramphenicol-treated cells (leading 70S); tRNA-Ala (E-site) 8p8v 7 75 8.7 RF00005 39668257 0030533 272634 gguuccaugguguaguggauaacauaucucccugucacggagggguugcggguucgauucccguuggaaccgcca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>....<<<<<.......>>>>>>>>>>>>.... (((((((...(((........)))...((((.......))))......((((.......)))).))))))).... Mycoplasma pneumoniae di-ribosome in chloramphenicol-treated cells (leading 70S); tRNA-Asp (P-site) 8p8v 8 76 8.7 RF00005 39668257 0030533 272634 gcaucuuuagcucaguugguagagcaaaugacucuuaaucauugggucggggguucgagccccucaagaugcacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).(((((.......))))).....(.(((..]....))).)))))))).... Mycoplasma pneumoniae di-ribosome in chloramphenicol-treated cells (leading 70S); tRNA-Lys (A-site) 8p8v Y 40 8.7 39668257 272634 aaagaaaacugccgauaaggucuucaaaaaaaagaaaacu ........................................ ........................................ Mycoplasma pneumoniae di-ribosome in chloramphenicol-treated cells (leading 70S); mRNA 8p8w 3 2893 8.7 RF02540,RF02541,RF02543,RF00002 39668257 0003735 0005840 272634 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((([.....((((.(((((.....(((..(((((((((((((......((((((....[[[[)))...].((((((...(((]]]....)))......))))))...)))....(((....)))((((((((....)))))))).(((((((((.........))))))))).))....((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...(((((......)))))....[.(((((((((.....(....((((((((((.(((...(((((......)))))[[......(((.....]])))...)))...))))))))))...)..)))))..)))))....(((((((((....).))))))))....].(((((..[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((....))))............)).....))))).)))).....(.((((..((((..[...))))..)))).<.(((........))).((((((....(((.(((((((((....((...(((.....)))...))....((....))..((((.....))))....))))))))).)))..((.(...((((((.....((((((((((.((((...((((((......))))))...)<)))...(((.((.((........)).)))))..).))))))))).(.((.......))...)..))))))......).))..((((((....(((((....)))))((((((((....((((((.(((.....(((....(((.(((((.....((((.....))))......))))).)))..)).).....))).))))))...)))))).))..((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(((((((.....(.....((..(((((((.((.....{..((((.(.([.(((.........)))..).).....(]..((......)).).))))....)).))))))).))...........]]].)...))))))))))...)))))))(((((((....)))))))....))))))(.((((((((((......(((((.((....))])))))...))))))))))..).....)))))).......((...((((((.......))))))((((....(((...((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((((((((((...(((((...((((..((((..(((((((((.....{{...)))))((..(((((..(((((((((((.((.....)))))))))....))))..)))))...))(..((....((....)).....))...)))))....))))...))))(..)....)))))..)).....))))))))))))))).))).....((......))..))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.[..).....)))))((((((......))))))(...).......(((((((((.>.((.........))...(((((((.....(((....))).......))))))).]((((.(((..(((((((..(((...((..((((((..((....))...))))))..))...))))))))..)))))(((((.........)))))........((..........(.(((.......))).)..)..)....))))...)).))))))).)..))).)))))))).))))))......).[..(((((.....>].)))))..(((((((..(((.((......((((.((((((..(((((.(((((((((.((.(((.((.....((........[..(((((..(((.......((..(.......)..).)....)))...........].)))))..)).....)).))).))...(((..(((((.....))))).)))....)))))))))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((]..[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].......(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....))..))).)))))))[...(((((((....(((..(((((((.....(....)....)))))))((((((...((((...(((((((((((.}}.))))))..)))))...)))).))))))..(((....((((.....}.......))))....))).)))...]....)))))))(.((((...]))))....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))...)))) Mycoplasma pneumoniae di-ribosome in chloramphenicol-treated cells (following 70S); 23S ribosomal RNA 8p8w 4 108 8.7 RF00001 39668257 0003735 0005840 272634 uuuggugcccaugucgcuguggaaacaccugguuccauuucgaacccagcaguuaagcacaguggagccgaauguagcuguuucagugagaauaggaaagcaccaagc <<<<<<<<.....<<<<<<<<.....<<<<<<.............>>>>..>>....>>>>>>.>>.<<..<..<.<<<<...>>>>...>.>.>>...>>>>>>>>. .(((((((.....((((((((.....((((((...(.....)...))))..))....)))))).)).((.......((((...)))).......))...))))))).. Mycoplasma pneumoniae di-ribosome in chloramphenicol-treated cells (following 70S); 5S ribosomal RNA 8p8w 5 1507 8.7 RF00177,RF01959,RF02542,RF01960 39668257 0003735 0005840 272634 ucugagaguuugauccuggcucaggauuaacgcuggcggcaugccuaauacaugcaagucgaucgaaaguaguaauacuuuagaggcgaacgggugaguaacacguauccaaucuaccuuauaaugggggauaacuaguugaaagacuagcuaauaccgcauaagaacuuugguucgcaugaaucaaaguugaaaggaccugcaaggguucguuauuugaugagggugcgccauaucagcuaguuggugggguaacggccuaccaaggcaaugacguguagcuaugcugagaaguagaauagccacaaugggacugagacacggcccauacuccuacgggaggcagcaguagggaauuuuucacaaugagcgaaagcuugauggagcaaugccgcgugaacgaugaaggucuuuaagauuguaaaguucuuuuauuugggaagaaugacuuuagcagguaauggcuagaguuugacuguaccauuuugaauaagugacgacuaacuaugugccagcagucncgguaauacauaggucgcaagcguuauccggauuuauugggcguaaagcaagcgcaggcggauugaaaagucugguguuaaaggcagcugcuuaacaguuguaugcauuggaaacuauuaaucuagagugugguagggaguuuuggaauuucauguggagcggugaaaugcguagauauaugaaggaacaccaguggcgaaggcgaaaacuuaggccauuacugacgcuuaggcuugaaaguguggggagcaaauaggauuagauacccuaguaguccacaccguaaacgauagauacuagcugucggggcgauccccucgguagugaaguuaacacauuaaguaucucgccuggguaguacauucgcaagaaugaaacucaaacggaauugacggggacccgcacaagugguggagcauguugcuuaauucgacgguacacgaaaaaccuuaccuagacuugacauccuuggcaaaauuauggaaacauaauggagguuaaccgagugacagguggugcaugguugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuuaucguuaguuacauugucuagcgagacugcuaaugcaaauuggaggaaggaagggaugacgucaaaucaucaugccccuuaugucuagggcugcaaacgugcuacaauggccaauacaaacagucgccagcuuguaaaagugagcaaaucuguaaaguuggucucaguucggauugagggcugcaauucguccucaugaagucggaaucacuaguaaucgcgaaucagcuaugucgcggugaauacguucucgggucuuguacacacngnccgucaaacuaugaaagcugguaauauuuaaaaacguguugcuaaccauuaggaagcgcaugucaaggauagcaccggugauuggaguuaagucguaacaagguaccccuacgagnncguggggguggaucacc .....<<<<..[.(((..>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<....>>>>>>.>>>>>......<<........<<<<<<<..<<...<..<<<<<<.<<.....<<<<<<....>>>>>>......>>.>.....<<<<<<<<<<<....>>>>>>>>>>>....<<<<<<....>>>>>>>>>>>..>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<...>>>>>.....>>>>...<<..<<<.......<<<<<<<<<........>>>>>>>>.>.......>>>...>>.....<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<..<<<<<<<<<<.....<<<<<<<.....>>>>>>>..>>>>>>>>..>>.>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<<..<<<......>>>.....>>>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<......>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<.....<<<<<....>>>>>...>>>....))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<.....<<<<<<....>>>>>>..........>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<.........>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>....>>>>>>>......<..<.<<<<<<<........>>>>>>>>...>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<..<<<<<....<<<<<<.<<<..<<....>>.>>>>>>>>>...>>>>>..>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>........ .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((....)))))).)))))......(((.......(((((((..((...(..((((((.((.....((((((....))))))......)).).....(((((((((.(....).)))))))))....((((((....)))))))))))..)..))))))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(..((...(((((....)))).))).).)).))))))..((((......((((.....)))).....)))).......(((...(....(((.((((........)))).)))....)....)))..........((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.((((((..((((((((((.....(((((((.....)))))))..))))))))..)).))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((......))))))))))...((..]])).....)))))))))).(((.......(((....))).....)))....]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...((((.((....((((((....)))))).........)).)).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((.........)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....))))))))..)).)))))))).(...(((((((.....(((..(((.((((....))))).))....)))....)))))))......(....(((((.(........).)))))....)..)..))))).....(((((((..........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((..(((((....((((((.(((..((....)).)))))))))...)))))..))))))..))).))))..).))...)..)..(((((((((....)))))))))}....... Mycoplasma pneumoniae di-ribosome in chloramphenicol-treated cells (following 70S); 16S ribosomal RNA 8p8w 6 76 8.7 RF00005 39668257 0030533 272634 ggggauguagcucaacugauagagcaccugauuugcacucaggagguugaggguuugagacccuucaucuccacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... ((.((((..((((........)))).(((((.......)))))......((((.......)))).)))).)).... Mycoplasma pneumoniae di-ribosome in chloramphenicol-treated cells (following 70S); tRNA-Ala (E-site) 8p8w 7 75 8.7 RF00005 39668257 0030533 272634 gguuccaugguguaguggauaacauaucucccugucacggagggguugcggguucgauucccguuggaaccgcca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>....<<<<<.......>>>>>>>>>>>>.... (((((((...(((........)))...((((.......))))......((((.......)))).))))))).... Mycoplasma pneumoniae di-ribosome in chloramphenicol-treated cells (following 70S); tRNA-Asp (P-site) 8p8w Y 29 8.7 39668257 272634 aagaaaacugccgauaaggucuucaaaaa ............................. ............................. Mycoplasma pneumoniae di-ribosome in chloramphenicol-treated cells (following 70S); mRNA 8p9a 1 3149 2.9 RF02540,RF02541,RF02543 0003735 0005840 4932 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........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<.<<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<......<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<...<<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>>.<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<<..<<<<<<.....>>>>>>>>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<..<....<<.........>>....>..........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<<....>>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<....<<..>>.....>>>>><<.<<<<<<.<<<......>>>...>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<...<<.....<<<<....>>>>.....>>.>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<.....>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<..<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>..>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<.<..<<<<........>>>>..>>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....(((((((((((((((((((((((.......(((((((......((((((....)))))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((...((.(((.....))).)).)))).)..)))..)).).....)))))...((((..(((.(......))))..)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((...(...((.........))...)...........(........)...)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....))).........(.................)....))....))...(((((........)))))]]((((..(((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((...(...)..))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.........)))))))....((((.....((((..(((..........)))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......(((((..(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).)))..)))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(.(..(..)....).)..)))))...)))....)))).)))))).))))).. 80S yeast ribosome in complex with Methyllissoclimide; 25S ribosomal RNA 8p9a 3 121 2.9 RF00001 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). 80S yeast ribosome in complex with Methyllissoclimide; 5S ribosomal RNA 8p9a 4 158 2.9 RF00002 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... 80S yeast ribosome in complex with Methyllissoclimide; 5.8 ribosomal RNA 8p9a AR 3130 2.9 RF02540,RF02541,RF02543 0003735 0005840 4932 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(((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). 80S yeast ribosome in complex with Methyllissoclimide; 5S ribosomal RNA 8p9a AT 158 2.9 RF00002 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... 80S yeast ribosome in complex with Methyllissoclimide; 5.8 ribosomal RNA 8p9a A 1741 2.9 RF01960,RF02542,RF01959,RF00177 0003735 0005840 4932 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80S yeast ribosome in complex with Methyllissoclimide; 16S ribosomal RNA 8p9a sR 1783 2.9 RF01960,RF02542,RF01959,RF00177 0003735 0005840 4932 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...<<<<<.{.[[[[>>>>><<<<.<<<<<<...<.<...<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<..<<..<<....<<<...............<.....<<.<<.......>>.>>......>.........<<<<<..<<....>>..>>>>><...<<<<<<......(((((((.<<<<..>>>>..............>>>>>>.....>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>..>>>..>....>.>.....<<<<<<<<<...........>.>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>>.........<<<[[.....<.<<...<<<.<<....<<<<<<.<<<..<<<<<.>>>>>......>>>.>>>>>>....<<<<<<....<<..<<<<.......>>>>..>>....>>>>>>...<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........<<<..<<<<<<<<.....))))))).>>>>>>>>.>>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..]]>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..]]]].}<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<......<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<<<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>...>.>>>>>>>.......>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>......<....<<<<<<..........>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<.<<<..<........>....>>>.>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... 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80S yeast ribosome in complex with Methyllissoclimide; 16S ribosomal RNA 8peg 7 2903 3.3 RF02541 38409277 0003735 0005840 562 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Escherichia coli paused disome complex (queueing 70S non-rotated closed PRE state); 23S ribosomal RNA 8peg 8 120 3.3 RF00001 38409277 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Escherichia coli paused disome complex (queueing 70S non-rotated closed PRE state); 5S ribosomal RNA 8peg A 1542 3.3 RF00177,RF01959,RF02542,RF01960 38409277 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggaucaccuccuua ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<..<......>..>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<.......<<<....>>>......>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<...<<....>>..>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.............. ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((............))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((((.......)))))))).....)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....))))))).............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}............. Escherichia coli paused disome complex (queueing 70S non-rotated closed PRE state); 16S ribosomal RNA 8peg V 30 3.3 38409277 562 aaaaaggacggugagcuucgugacaauuaa .............................. .............................. Escherichia coli paused disome complex (queueing 70S non-rotated closed PRE state); mRNA 8peg W 76 3.3 38409277 562 gcccgganagcucagnnggnagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((.........)))).....((.((..]....)).))))))))).... Escherichia coli paused disome complex (queueing 70S non-rotated closed PRE state); tRNA-Phe (P-site) 8peg X 78 3.3 38409277 562 ggugaggnggccgagaggcngaaggcgcucccnugcunagggaguauauccggggnucgaauccccgccucaccgcca .<<<<<<..<<<...........>>>.<<<<<.......>>>>>......<<<<<.......>>>>>>>>>>>..... (((((((..(((..[........))).(((((.......))))).(())](((((.......)))))))))))).... Escherichia coli paused disome complex (queueing 70S non-rotated closed PRE state); tRNA-Ser (E-site) 8peg Y 76 3.3 RF00005 URS00003179F7_83333 38409277 0030533 0006412 562 ggguganuagcucagcugggagagcaccucccunacnaggaggggnucggcggnucgaucccgucaucacccacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((.........)))).....(((((..]....)))))))))))).... Escherichia coli paused disome complex (queueing 70S non-rotated closed PRE state); tRNA-Val (A-site) 8pfk A 12 1.321 URS000080E0B7_32630 38235959 32630 cgcgaanuagcg ............ ............ RNA structure with 1-methylpseudouridine, C2 space group; RNA (12-mer) 8pfq A 12 1.01 URS000080E0B7_32630 38235959 32630 cgcgaanuagcg ............ ............ RNA structure with 1-methylpseudouridine, P1 space group; Chains: A,B 8pfq B 12 1.01 URS000080E0B7_32630 38235959 32630 cgcgaanuagcg ............ ............ RNA structure with 1-methylpseudouridine, P1 space group; Chains: A,B 8pfr A 3038 2.15 RF02543 39041433,29872004 0003735 0005840 4932 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacaggaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcggaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaaguacuuauucaaugaagcggagcuggaccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<<.<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<......<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<......>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<...<<....>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<......<..........<<<.<<<<<<<<<<..........>>>>>>>>>>>>>..........))).>....>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>..>.....>>>>>><<<....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<..<<<.....>.>>..>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>...<...<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>...>......>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<....>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>.<.<<..<<<..<<<<<<.<...<<....<<<<<....>>>>.>...>>.>>>>>..>>>>>........<...........<<<<<.......>>>>>.....>.....>>.>..>>.>>>>>>>.....>>.>>>>>>>..>>>>>>...>>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<...>>>...<<<<<.....<<<<..<<<.>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<..<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>..>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.(((((......(((((((((((((((((((((((.......(((((((......((((........)))).......))))))).....))))).))))))))))........(((....)))....)))))))).....))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((............)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((..........)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))...........(.((.....).)..)......))....))...(((((........)))))]]((((.(((((((....((((....))).....<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))....).....)))..)))))))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((((....))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..((.....))....((((.....((((..(((.)))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.............))))...)))).))))....)))))))).......(((((..(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).)))..)))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(((.((..)..).)))..)))))...)))....)))).)))))).))))).. Mouse RPL39L integrated into the yeast 60S ribosomal subunit; 25S rRNA 8pfr LD 158 2.15 RF00002 39041433,29872004 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Mouse RPL39L integrated into the yeast 60S ribosomal subunit; 5.8S rRNA 8pfr LE 121 2.15 RF00001 39041433,29872004 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Mouse RPL39L integrated into the yeast 60S ribosomal subunit; 5S rRNA 8phj 7 76 3.67 RF00005 URS00001BBAFC_562 38033086 0030533 0006412 562 gcggggnggagcagccuggnagcucgucgggnucauaacccgaagaucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... cA4-bound Cami1 in complex with 70S ribosome; fMet-tRNA(fMet) 8phj 8 77 3.67 RF00005 URS00001BBAFC_562 38033086 0030533 0006412 562 cgcggggnggagcagccuggnagcucgucgggnucauaacccgaagaucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(((((.......)))))))))))..... cA4-bound Cami1 in complex with 70S ribosome; fMet-tRNA(fMet) 8phj A 1503 3.67 RF00177,RF01959,RF02542,RF01960 URS00000ABFE9_562 38033086 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaaguuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugccggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccgaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<.>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<.>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<..>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>........>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((.))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((.)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(..(.((((((((.......)))))))).)...)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((((())))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((.(((....))).)))........))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... cA4-bound Cami1 in complex with 70S ribosome; 16S rRNA 8phj a 2862 3.67 RF02541 URS00004B0F34_562 38033086 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcgcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauagguggggacgccagucuccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<..<<<<.....>>>>...>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<..>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<..<<....>>...>>>>>..>....>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<.............<<<.<<<<....>>>>.>>>....>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((((((.....))))).))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((((()))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((.(((..(((.(.........((.((((((....)))))).))).)))..))).)))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). cA4-bound Cami1 in complex with 70S ribosome; 23S rRNA (2862-MER) 8phj b 119 3.67 RF00001 URS0000049E57_562 38033086 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>> ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))) cA4-bound Cami1 in complex with 70S ribosome; 5S rRNA 8pj1 7 47 3.4 39289545 9606 aacaacaacaacaacaacaacaacaaggauccaaaacagaccaccau ............................................... ............................................... Structure of human 48S translation initiation complex in open codon scanning state (48S-1); mRNA 8pj1 A 1754 3.4 RF01960,RF02542,RF01959,RF00177 39289545 0003735 0005840 9606 uaccugguugauccugccaguagcaunugcuugucucaaagauuaagccaugcaugucugaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuauggunccuunggucgcucgcuccuacuuggauaacugugguanuucuagngcuaauanaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgccccccguggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcnaauuacccacucccgacccgggganguagugangaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauancguauauuaaaguugcugcaguunaaaagcucguaguungaucuugggagcgggcgggcgguccgccgcgaggcgagccaccgcccguccccgccccucucggcggcccgaagcguuuacuuugaaaaaanuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagancgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccacnaggaguggagccugcggcuuaauuugacncaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauucngauaacgaacgagacucuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauunagucccugcccuuuguacacaccgnccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccgggggcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucgnancaagguuuccguaggugnnccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<....<<....<<<<<.............<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<........>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<<......>>>>>>>>.>>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....<..<...<<..<<....>>..>>.....>...>.....<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<.....<..<<<<<<<<<<<<<.<<<<....>>>>....>>>>>>>>..>>>>>.><<.............>>...<<<<<<.<.......<<...<.......>.<<<<.......>>>>...>>......>.>>>..>>>........<.<<.<<<.<..................>..>>>.>>.>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<........>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<.......>>>>.>>>>.....>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<...<.<<<<<..........>>>>>>....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<.......................>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..((....((((....((....[...((.....((.(((.....))).))......))......)).((((...((((........))))...))))((..(((((...(......)..)))))......)).(]((((.((((......))))))))).).)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).).....(......((.(((....))).))........)....(.((..(...........)..))......)..((((([[....(.((((.....((..]])).......))))))))))..)))))).)))..[......(.([[...(.(.((...(((..(......(.(((((((((((((.((((....))))....))))))))..))))).)((.............))...((((((.(.......((..((.......)).(((.......)))....))......).)))..)))........(.((.(.(...(...............)...).).)).)....)....(((.((...(...((((..((..((((((((...((........))......))))))))..)).......((....))...))))..)...))..))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.((((......)))))))))).)..)))...((..]]))...))...].))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....((((((....(..((.(((........))).))....)))))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((...(...((((..((((((((((((.......)))).)))).....))))..))))..).....(((((.....)))))........)))....))).))).....).))))).....).)))))...)).)))).))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..((((.((...((((.(......................)))))...)).))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}........ Structure of human 48S translation initiation complex in open codon scanning state (48S-1); 18S rRNA 8pj1 w 75 3.4 RF00005 39289545 0030533 9606 agcagaguggcgcagcggaagcgugcugggcccauaacccagaggucgauggaucgaaaccauccucugcuacca <<<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((....[..)))).(((((.......))))).....(((((..]....)))))))))))).... Structure of human 48S translation initiation complex in open codon scanning state (48S-1); Initiator Met-tRNA-i 8pj2 7 57 3.4 39289545 9606 acaacaacaacaacaaggauccaaaacagaccaccaugguacguuucaaggcuugag ......................................................... ......................................................... Structure of human 48S translation initiation complex in AUG recognition state after eIF5-induced GTP hydrolysis by eIF2 (48S-2); mRNA 8pj2 A 1754 3.4 RF01960,RF02542,RF01959,RF00177 39289545 0003735 0005840 9606 uaccugguugauccugccaguagcaunugcuugucucaaagauuaagccaugcaugucugaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuauggunccuunggucgcucgcuccuacuuggauaacugugguanuucuagngcuaauanaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgccccccguggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcnaauuacccacucccgacccgggganguagugangaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauancguauauuaaaguugcugcaguunaaaagcucguaguungaucuugggagcgggcgggcgguccgccgcgaggcgagccaccgcccguccccgccccucucggcggcccgaagcguuuacuuugaaaaaanuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagancgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccacnaggaguggagccugcggcuuaauuugacncaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauucngauaacgaacgagacucuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauunagucccugcccuuuguacacaccgnccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccgggggcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucgnancaagguuuccguaggugnnccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<....<<....<<<<<.............<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<........>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<<......>>>>>>>>.>>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....<..<...<<..<<....>>..>>.....>...>.....<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<........<<<<<<<<<<<<<.<<<<....>>>>....>>>>>>>>..>>>>>..<<.............>>...<<<<<<.<.......<<...<.......>.<<<<.......>>>>...>>......>.>>>..>>>........<.<<.<<<<<..................>>.>>>.>>.>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<........>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<.......>>>>.>>>>.....>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<.......................>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..((....((((....((....[...((.....((.(((.....))).))......))......)).((((...((((........))))...))))((..(((((...(......)..)))))......)).(]((((.((((......))))))))).).)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).).....(.....(((.(((....))).)).)......)....(.((..(...........)..))......)..((((([[....(.((((.....((..]])).......))))))))))..)))))).)))..[......(.([[...(.(.((...(((..(.....((.(((((((((((((.((((....))))....))))))))..)))))))((.............))...((((((.(.......((..((.......)).(((.......)))....))......).)))..)))........(.((.(.(...(...............)...).).)).)....)....(((.((.(.(...((((..((..((((((((...((........))......))))))))..)).......((....))...))))..)..)))..))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.((((......)))))))))).)..)))...((..]]))...))...].))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((...(...((((..((((((((((((.......)))).)))).....))))..))))..).....(((((.....)))))........)))....))).))).....).))))).....).)))))...)).)))).))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..((((.((...((((.(......................)))))...)).))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}........ Structure of human 48S translation initiation complex in AUG recognition state after eIF5-induced GTP hydrolysis by eIF2 (48S-2); 18S rRNA 8pj2 w 75 3.4 RF00005 39289545 0030533 9606 agcagaguggcgcagcggaagcgugcugggcccauaacccagaggucgauggaucgaaaccauccucugcuacca <<<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((....[..)))).(((((.......))))).....(((((..]....)))))))))))).... Structure of human 48S translation initiation complex in AUG recognition state after eIF5-induced GTP hydrolysis by eIF2 (48S-2); Initiator Met-tRNA-i 8pj3 7 57 3.7 39289545,28710774 9606 acaacaacaacaacaaggauccaaaacagaccaccaugguacguuucaaggcuugag ......................................................... ......................................................... Structure of human 48S translation initiation complex upon transfer of initiator tRNA to eIF5B (48S-3); mRNA 8pj3 A 1754 3.7 RF01960,RF02542,RF01959,RF00177 39289545,28710774 0003735 0005840 9606 uaccugguugauccugccaguagcaunugcuugucucaaagauuaagccaugcaugucugaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuauggunccuunggucgcucgcuccuacuuggauaacugugguanuucuagngcuaauanaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgccccccguggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcnaauuacccacucccgacccgggganguagugangaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauancguauauuaaaguugcugcaguunaaaagcucguaguungaucuugggagcgggcgggcgguccgccgcgaggcgagccaccgcccguccccgccccucucggcggcccgaagcguuuacuuugaaaaaanuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagancgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccacnaggaguggagccugcggcuuaauuugacncaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauucngauaacgaacgagacucuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauunagucccugcccuuuguacacaccgnccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccgggggcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucgnancaagguuuccguaggugnnccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<....<<....<<<<<.............<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<........>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<<......>>>>>>>>.>>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....<..<...<<..<<....>>..>>.....>...>.....<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<........<<<<<<<<<<<<<.<<<<....>>>>....>>>>>>>>..>>>>>..<<.............>>...<<<<<<.<.......<<...<.......>.<<<<.......>>>>...>>......>.>>>..>>>........<.<<.<<<<<..................>>.>>>.>>.>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<........>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<.......<<........>>..........<<<<<.<....<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<.......>>>>.>>>>.....>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.....>.>>>>>....>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>............<<<<<..........>>>>>...........>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<.......................>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..((....(((.....((....[...((.....((.(((.....))).))......))......)).((((...((((........))))...))))((..(((((...(......)..)))))......)).(]((((.((((......)))))))))...)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.((....((((.]...))).).))).)...)).).....(......((.(((....))).))........)....(.((..(...........)..))......)..((((([[....(.((((.....((..]])).......))))))))))..)))))).)))..[......(.([[...(.(.((...(((..(.....((.(((((((((((((.((((....))))....))))))))..)))))))((.............))...((((((.(.......((..((.......)).(((.......)))....))......).)))..)))........(.((.(.(...(...............)...).).)).)....)....(((.((...(...((((..((..((((((((...((........))......))))))))..)).......((....))...))))..)...))..))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.((((......)))))))))).)..)))...((..]]))...))...].))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((...(...((((..((((((((((((.......)))).)))).....))))..))))..).....(((((.....)))))........)))....))).))).....).))))).....).)))))...)).)))).))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....(((((.((.......)).)))))......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..((((.((...((((.(......................)))))...)).))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}........ Structure of human 48S translation initiation complex upon transfer of initiator tRNA to eIF5B (48S-3); 18S rRNA 8pj3 w 75 3.7 RF00005 39289545,28710774 0030533 9606 agcagaguggcgcagcggaagcgugcugggcccauaacccagaggucgauggaucgaaaccauccucugcuacca <<<<<<...<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>.>>>>>>.... .((((((..((((....[..)))).(((((.......))))).....(((((..]....)))))))))))..... Structure of human 48S translation initiation complex upon transfer of initiator tRNA to eIF5B (48S-3); Initiator Met-tRNA-i 8pj4 7 57 3.2 39289545,28710774 9606 acaacaacaacaacaaggauccaaaacagaccaccaugguacguuucaaggcuugag ......................................................... ......................................................... Structure of human 48S translation initiation complex after eIF5 release (48S-4); mRNA 8pj4 A 1754 3.2 RF01960,RF02542,RF01959,RF00177 39289545,28710774 0003735 0005840 9606 uaccugguugauccugccaguagcaunugcuugucucaaagauuaagccaugcaugucugaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuauggunccuunggucgcucgcuccuacuuggauaacugugguanuucuagngcuaauanaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgccccccguggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcnaauuacccacucccgacccgggganguagugangaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauancguauauuaaaguugcugcaguunaaaagcucguaguungaucuugggagcgggcgggcgguccgccgcgaggcgagccaccgcccguccccgccccucucggcggcccgaagcguuuacuuugaaaaaanuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagancgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccacnaggaguggagccugcggcuuaauuugacncaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauucngauaacgaacgagacucuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauunagucccugcccuuuguacacaccgnccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccgggggcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucgnancaagguuuccguaggugnnccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<....<<....<<<<<.............<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<........>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<<......>>>>>>>>.>>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....<..<...<<..<<....>>..>>.....>...>.....<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<.....<..<<<<<<<<<<<<<.<<<<....>>>>....>>>>>>>>..>>>>>.><<.<.........>.>>...<<<<<<.<.......<<...<.......>.<<<<.......>>>>...>>......>.>>>..>>>........<.<<.<<<<<..................>>.>>>.>>.>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<........>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<.......>>>>.>>>>.....>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<.......................>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..((....(((.....((....[...((.....((.(((.....))).))......))......)).((((...((((........))))...))))((..(((((...(......)..)))))......)).(]((((.((((......)))))))))...)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).).....(.....(((.(((....))).)).)......)....(.((..(...........)..))......)..((((([[....(.((((.....((..]])).......))))))))))..)))))).)))..[......(.([[...(.(.((...(((.((.....((.(((((((((((((.((((....))))....))))))))..)))))))((.............))...((((((.(.......((..((.......)).(((.......)))....))......).)))..)))........(.((.(.(...(...............)...).).)).)....))...((((((...(...((((..((..((((((((...((........))......))))))))..)).......((....))...))))..)...)).)))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.((((......)))))))))).)..)))...((..]]))...))...].))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((...(...((((..((((((((((((.......)))).)))).....))))..))))..).....(((((.....)))))........)))....))).))).....).))))).....).)))))...)).)))).))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..((((.((...((((.(......................)))))...)).))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}........ Structure of human 48S translation initiation complex after eIF5 release (48S-4); 18S rRNA 8pj4 w 75 3.2 RF00005 39289545,28710774 0030533 9606 agcagaguggcgcagcggaagcgugcugggcccauaacccagaggucgauggaucgaaaccauccucugcuacca <<<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((....[..)))).(((((.......))))).....(((((..]....)))))))))))).... Structure of human 48S translation initiation complex after eIF5 release (48S-4); Initiator Met-tRNA-i 8pj5 7 56 2.9 39289545 9606 caacaacaacaacaaggauccaaaacagaccaccaugguacguuucaaggcuugag ........................................................ ........................................................ Structure of human 48S translation initiation complex after eIF2 release prior 60S subunit joining (48S-5); mRNA 8pj5 A 1754 2.9 RF01960,RF02542,RF01959,RF00177 39289545 0003735 0005840 9606 uaccugguugauccugccaguagcaunugcuugucucaaagauuaagccaugcaugucugaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuauggunccuunggucgcucgcuccuacuuggauaacugugguanuucuagngcuaauanaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgccccccguggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcnaauuacccacucccgacccgggganguagugangaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauancguauauuaaaguugcugcaguunaaaagcucguaguungaucuugggagcgggcgggcgguccgccgcgaggcgagccaccgcccguccccgccccucucggcggcccgaagcguuuacuuugaaaaaanuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagancgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccacnaggaguggagccugcggcuuaauuugacncaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauucngauaacgaacgagacucuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauunagucccugcccuuuguacacaccgnccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccgggggcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucgnancaagguuuccguaggugnnccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<....<<....<<<<<.............<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<........>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<<......>>>>>>>>.>>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....<..<...<<..<<....>>..>>.....>...>.....<<..<...........>..>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<.....<..<<<<<<<<<<<<<.<<<<....>>>>....>>>>>>>>..>>>>>.><<.............>>...<<<<<<.<.......<<...<.......>.<<<<.......>>>>...>>......>.>>>..>>>........<.<<.<<<.<..................>..>>>.>>.>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<........>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<.......>>>>.>>>>.....>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<...<.<<<<<..........>>>>>>....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<.......................>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..((....(((.....((....[...((.....((.(((.....))).))......))......)).((((...((((........))))...))))((..(((((...(......)..)))))......)).(]((((.((((......)))))))))...)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).).....(......((.((......)).))........)....(.((..(...........)..))......)..((((([[....(.((((.....((..]])).......))))))))))..)))))).)))..[......(.([[...(.(.((...(((..(.....((.(((((((((((((.((((....))))....))))))))..)))))))((.............))...((((((.(.......((..((.......)).(((.......)))....))......).)))..)))........(.((.(.(...(...............)...).).)).)....)....(((.((...(...((((..((..((((((((...((........))......))))))))..)).......((....))...))))..)...))..))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.(((........))))))))).)..)))...((..]]))...))...].))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((...(...((((..((((((((((((.......)))).)))).....))))..))))..).....(((((.....)))))........)))....))).))).....).))))).....).)))))...)).)))).))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..((((.((...((((.(......................)))))...)).))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}........ Structure of human 48S translation initiation complex after eIF2 release prior 60S subunit joining (48S-5); 18S rRNA 8pj5 w 75 2.9 RF00005 39289545 0030533 9606 agcagaguggcgcagcggaagcgugcugggcccauaacccagaggucgauggaucgaaaccauccucugcuacca <<<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((....[..)))).(((((.......))))).....(((((..]....)))))))))))).... Structure of human 48S translation initiation complex after eIF2 release prior 60S subunit joining (48S-5); Initiator Met-tRNA-i 8pj6 7 56 2.9 39289545 9606 caacaacaacaacaaggauccaaaacagaccaccaugguacguuucaaggcuugag ........................................................ ........................................................ Structure of human 48S translation initiation complex with initiator tRNA, eIF1A and eIF3 (off-pathway); mRNA 8pj6 A 1719 2.9 RF01960,RF02542,RF01959,RF00177 39289545 0003735 0005840 9606 uaccugguugauccugccaguagcaunugcuugucucaaagauuaagccaugcaugucugaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuauggunccuunggucgcucgcuccuacuuggauaacugugguanuucuagngcuaauanaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgccccccguggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcnaauuacccacucccgacccgggganguagugangaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauancguauauuaaaguugcugcaguunaaaagcucguaguungaucuugggagcggccccgccccucucggcggcccgaagcguuuacuuugaaaaaanuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagancgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccacnaggaguggagccugcggcuuaauuugacncaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauucngauaacgaacgagacucuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauunagucccugcccuuuguacacaccgnccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccgggggcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucgnancaagguuuccguaggugnnccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<....<<....<<<<<.............<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<........>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<<......>>>>>>>>.>>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....<..<...<<..<<....>>..>>.....>...>.....<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<....<<<.<......>.>>><<.............>>...<<<<<<.<.......<<...<.......>.<<<<.......>>>>...>>......>.>>>..>>>........<.<<.<<<.<..................>..>>>.>>.>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<........>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<.......<<........>>..........<<<<<.<....<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<.......>>>>.>>>>.....>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.....>.>>>>>....>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>............<<<<<..........>>>>>...........>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<.......................>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..((....((((....((....[...((.....((.(((.....))).))......))......)).((((...((((........))))...))))((..(((((...(......)..)))))......)).(]((((.((((......))))))))).).)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).).....(......((.(((....))).))........)....(.((..(...........)..))......)..((((([[....(.((((.....((..]])).......))))))))))..)))))).)))..[......(.([[...(.(.((...(((..(....(((.(......).)))((.............))...((((((.(.......((..((.......)).(((.......)))....))......).)))..)))........(.((.(.(.......................).).)).)....)....(((.((...(...((((..((..((((((((...((........))......))))))))..)).......((....))...))))..)...))..))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.((((......)))))))))).)..)))...((..]]))...))...].))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((...(...((((..((((((((((((.......)))).)))).....))))..))))..).....(((((.....)))))........)))....))).))).....).))))).....).)))))...)).)))).))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(.(((((((..(((..((((.((...((((.(......................)))))...)).))))..)))..))))))))..)).))))...).))...)..)..(((((((((....)))))))))}........ Structure of human 48S translation initiation complex with initiator tRNA, eIF1A and eIF3 (off-pathway); 18S rRNA 8pj6 w 73 2.9 RF00005 39289545 0030533 9606 agcagaguggcgcagcggaagcgugcugggcccauaacccagaggucgauggaucgaaaccauccucugcuac <<<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.. (((((((..((((....[..)))).(((((.......))))).....(((((..]....)))))))))))).. Structure of human 48S translation initiation complex with initiator tRNA, eIF1A and eIF3 (off-pathway); Initiator Met-tRNA-i 8pj9 B 36 3.24 1268061 cgcuaaagaggaagaggacaguuuuagagcuguguu .................................... .................................... Cas9 bound to cognate DNA, Streptococcus thermophilus DGCC 7710 CRISPR3 system; crRNA, chain B 8pj9 C 66 3.24 RF02348 1268061 aacacagcgaguuaaaauaaggcuuaguccguacucaacuugaaaagguggcaccgauucgguguu ....................<<......>>.......<<<......>>>.<<<<<<...>>>>>>. ....................(((...).)).......((((....)))).((((((...)))))). Cas9 bound to cognate DNA, Streptococcus thermophilus DGCC 7710 CRISPR3 system; tracrRNA, chain C 8pkl 7 2904 3.09 RF02541 38409277 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaucuu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<<.....>>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<..<<....>>..>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<..<<<.<<<<<.<<<<<<<<<<<.<<<............<<<<<............<...<<<....>>>...>...................>>>>>...>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>...>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>.. (.((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((((((.....))))).))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((.((....)).))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((.(......).(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.(((..(.........(((((............((..(((....)))..))...................))))))..))).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))).).. Escherichia coli paused disome complex (leading 70S non-rotated closed PRE state); 23S ribosomal RNA 8pkl 8 120 3.09 RF00001 38409277 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Escherichia coli paused disome complex (leading 70S non-rotated closed PRE state); 5S ribosomal RNA 8pkl A 1535 3.09 RF00177,RF01959,RF02542,RF01960 38409277 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggaucac ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<......>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..........>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<.......<<<....>>>......>>>>.....<<<<<........<<<.<<<<.......>>>>.>>>..........>>>>>.......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<..<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>.........>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<..<.<<<<<<<........>>>>>>>>...>.....>>>>>>.....<<<<<<.........>>>>>>.......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<...<<....>>..>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>....... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(...(((.(((((......)))))..))).)..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....))).....(((((..(......))))))..)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((.....(((....)))...)))).)).))))))..((((........((....)).......))))..(..(((((...(....((..((((.......))))..)).....)....))))).....).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...((.(((....))).))....((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((.(.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..).)).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(.(((((.........))))).)......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}...... Escherichia coli paused disome complex (leading 70S non-rotated closed PRE state); 16S ribosomal RNA 8pkl V 24 3.09 38409277 562 ucgcgcugggccaaaaucgaaaaa ........................ ........................ Escherichia coli paused disome complex (leading 70S non-rotated closed PRE state); mRNA 8pkl W 76 3.09 RF00005 38409277 0030533 562 aggggcgnaguucaannggnagagcaccgguuuccanaaccgggunuugggagnucgagucucuccgccccugcca <<<<<<<..<<<<........>>>><<<<<<<.....>>>>>>.>...<<<<<.......>>>>>>>>>>>>.... (((((((..(.((.....[..)).).(((((.......))))).....(.(((..]....))).)))))))).... Escherichia coli paused disome complex (leading 70S non-rotated closed PRE state); tRNA-Trp (P-site) 8pkl X 77 3.09 RF00005 38409277 0030533 562 gcauccgnagcucagcngganagaguacucggnuicgnaccgagcgnncggaggnucgaauccucccggaugcacca <<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.........)))).(((((.......))))).....(((((.......)))))))))))).... Escherichia coli paused disome complex (leading 70S non-rotated closed PRE state); tRNA-Arg (E-site) 8pkl Y 76 3.09 38409277 562 ggggcuauagcucagcngggagagcgcuugcauggcaugcaagagnucagcggnucgaucccgcuuagcuccacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).(((((.......))))).....(((((..]....)))))))))))).... Escherichia coli paused disome complex (leading 70S non-rotated closed PRE state); tRNA-Ala (A-site) 8pnf A 14 2.9 39537894 12131 auuuuuuuuuuuuu .............. .............. HRV B14 virion proteins; RNA (5'-R(P*AP*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*U)-3') 8pnq V 36 2.88 38316757 1318616 aguagaaacaaggguguauuuuccccucuuuuugcu .<<....>>........................... .((....))........................... Influenza A/H7N9 polymerase in elongation state with continuous Pol II pS5 CTD peptide mimic bound in site 1A/2A; 51-mer vRNA loop (v51_mut_S) 8poh V 14 3.3 38316757 1318616 aguagaaacaaggg .<<....>>..... .((....))..... Influenza A/H7N9 polymerase symmetric dimer bound to the promoter (PA K289A/C489R); 51-mer vRNA loop (v51_mut_S) 8poh U 14 3.3 38316757 1318616 aguagaaacaaggg .<<....>>..... .((....))..... Influenza A/H7N9 polymerase symmetric dimer bound to the promoter (PA K289A/C489R); 51-mer vRNA loop (v51_mut_S) 8ppl Iw 75 2.65 URS0000326EAC_9606 37802027 0030533 0006412 9606 agcagagunncgcagcggaagcguncugggcccaunacccagagnnngauggaucgnaaccauccucugcuacca <<<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.......)))).(((((.......))))).....(((((.......)))))))))))).... MERS-CoV Nsp1 bound to the human 43S pre-initiation complex; Met-tRNAi(Met) 8ppl A2 1780 2.65 RF01960,RF02542,RF01959,RF00177 URS00027E5AFD_9606 37802027 0003735 0005840 9606 uaccugguugauccugccaguagcaunugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucnuuaaaucaguuauggunccuunggucgcucguacuuggauaacugugguanuucuagngcuaananaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucagaucaaaaccaacccggugccggcggcuuuggugacucuagauaaccucgggccgaucgcacgccccccguggcggcgacgacccauucgaacgucngcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgaunccggaganggagccugagaaacggcuaccacauncaaggnaggcagcaggcgcgcnaauuacccacucccgacccggggangungugangaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaanuccuuuaacgaggnuccauuggagngcaagucuggugccagcagccgcggnaauuccagcuccaauancguauauuaaaguugcugcaguunaaaagcucguaguungaucuugggagcgggcgggcgguaccgcccguccccgcccgccucucggcgccccggggcccgaagngnuuacuuugaaaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagancgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacncaacacgggaaaccucacccggcncggacacggacagganugacagauugauagcucuuucucgauuccguggguggngnugcauggcnguucuuaguugguggagcgauuugucugguuaauuccgauaacgancgagacunuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuncuuanagggacaaguggcguucagccacccgagauugagcaauaacangucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgagnaauucccaguaagugcgggucauaagcuugcguugauunagucccugcccuuuguacacaccgnccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggucggcccacggcccuggcggagcgcugagaagacggucgaacungacuaucuagaggaaguaaaagucguancaagguuucnguaggugnnccugcggaaggaucauua ...<<<<<...[[[[>>>>>[[[.((((((.....{{.........[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[......{{....[[[{..........<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<<<....>>>>>>...>>>>[[..(((((.....<<<<<<<<<<<<<..>>>>.......<......>..)))))......]]...<<<<.<<<<......>>>>>>>>..}.]]]...}}....]]].<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<<...>>>>..>>>......}}.......<<<<<<<<<.<<<....>>>..>>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..)))))).]]]............{{.......{{...[[[.[[....<<<.<.<<<<<<<<<<..>>>>>>>>>>.>.>>><<...<<<..<<<<<>>>>>.>>>.>>..<<<<<<.<.......<<...<.......>.<<<<.......>>>>...>>......>.>>>..>>>........{.[[.(((((((.....>>>>>>>>>.))))))).]].}....]]....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<........>>>>>>>>>.>..>>>...<<..}}>>...>>.....>>>.....<<<......<<<......>>>....>>>..]]]]..<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<......<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<.......>>>>.>>>>.....>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.......>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>............<<<<<..........>>>>>...........>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<.<<<<<<<<<<<<.....>>>>>>>>>>>>...>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))((...(((((......(..((.....(((.(((..((....((....((..........))...)){))......(((.......(((.(.(..((....(((.....(({...((.....((.(((.....))).))......))......)).((((...((((((....))))))...))))((..(((((.....[[[[[[[[[((((())))).......(......)..)))))......)).(}((((.(((((...).)))))))))...)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)...)........(((((((((.(((....)))..)))))).)))......((..(...........)..)).........((((([[....(.(.((.....((..]])).......)).)))))))..)))))...))..{......(.({{...(.(.((...(.(..(....(((.(.((((((((((())))))))))).).)))((.(.(((..((((())))).))))))..(..(((.(........(..((.......)).((((...)..)))....).......).)))....)........(.((.(((((((.....]]]]]]]]].))))))).)).)....)....(((..(...(...(((...((..((((((((...(..........)......))))))))..)).......((....))....)))..)...)...))..)).)...)).)....((((((....(...((((.........))))...).))))))......<...(((.((..((..(.((((((.(((........))))))))).)..))....((..}}))...))...}.))))).).(((......((.(....).))....)))...]]].]((((..(((((((..((..((.((..(((..(((((.......(........)...........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....((..(((((....)))..(.((......)))...))..))....(((...(...((.(..(((((((((((((....).)))).)))).....))))..).))..).....(((((.....)))))........)))....))).))).....).))))).....).)))))...)).)))..))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....((((............)))).....)..)..)).)).....((((((((.......))))))))......))...))))))).)).))..(.(..((.(..((((.((..(.((((((((.(((..((((.((...((((((((((((.(((((.....))))).)))))).).)))))...)).))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>........ MERS-CoV Nsp1 bound to the human 43S pre-initiation complex; 18S rRNA 8psn V 13 2.73 URS000291569A_1549864 38066000 1549864 aaaucuuucucac <<...>>...... ((...))...... Tilapia Lake Virus polymerase in vRNA initiation state (transcriptase conformation); 5' vRNA end - vRNA loop (40-mer) 8psn S 15 2.73 URS000291569A_1549864 38066000 1549864 gugaguaaaauuugg ............... ............... Tilapia Lake Virus polymerase in vRNA initiation state (transcriptase conformation); 5' vRNA end - vRNA loop (40-mer) 8pso V 13 2.4 URS000291569A_1549864 38066000 1549864 aaaucuuucucac <<...>>...... ((...))...... Tilapia Lake Virus polymerase in vRNA initiation state (core only); 5' vRNA end - vRNA loop (40-mer) 8pso S 15 2.4 URS000291569A_1549864 38066000 1549864 gugaguaaaauuugg ............... ............... Tilapia Lake Virus polymerase in vRNA initiation state (core only); 5' vRNA end - vRNA loop (40-mer) 8psq V 13 2.65 URS000291567A_1549864 38066000 1549864 aaauuuuacucac <<...>>...... ((...))...... Tilapia Lake Virus polymerase in cRNA pre-initiation state mode A (core only); 5' cRNA end - cRNA loop (40-mer) 8psq S 15 2.65 URS000291567A_1549864 38066000 1549864 gugagaaagauuugc ............... ............... Tilapia Lake Virus polymerase in cRNA pre-initiation state mode A (core only); 5' cRNA end - cRNA loop (40-mer) 8pss V 14 2.83 URS000291567A_1549864 38066000 1549864 aaauuuuacucaca <<...>>....... ((...))....... Tilapia Lake Virus polymerase in cRNA pre-initiation state mode B (core-endo only); 5' cRNA end - cRNA loop (40-mer) 8pss S 15 2.83 URS000291567A_1549864 38066000 1549864 gugagaaagauuugc ............... ............... Tilapia Lake Virus polymerase in cRNA pre-initiation state mode B (core-endo only); 5' cRNA end - cRNA loop (40-mer) 8psu V 14 3.18 URS000291569A_1549864 38066000 1549864 aaaucuuucucacg <<...>>....... ((...))....... Tilapia Lake Virus polymerase in vRNA pre-initiation state mode A (core only); 5' vRNA end - vRNA loop (40-mer) 8psu S 15 3.18 URS000291569A_1549864 38066000 1549864 gugaguaaaauuugg ............... ............... Tilapia Lake Virus polymerase in vRNA pre-initiation state mode A (core only); 5' vRNA end - vRNA loop (40-mer) 8psx S 13 2.96 URS000291569A_1549864 38066000 1549864 gaguaaaauuugg ............. ............. Tilapia Lake Virus polymerase in vRNA elongation state (transcriptase conformation); 5' vRNA end - vRNA loop (40-mer) 8psx P 13 2.96 URS0002915695_1549864 38066000 1549864 auaccaaauuuua ............. ............. Tilapia Lake Virus polymerase in vRNA elongation state (transcriptase conformation); Transcription-like product 8psz V 13 2.42 URS000291569A_1549864 38066000 1549864 aaaucuuucucac <<...>>...... ((...))...... Tilapia Lake Virus polymerase in vRNA elongation state with additional mode B promoter (transcriptase conformation); 5' vRNA end - vRNA loop (40-mer) 8psz S 13 2.42 URS000291569A_1549864 38066000 1549864 gaguaaaauuugg ............. ............. Tilapia Lake Virus polymerase in vRNA elongation state with additional mode B promoter (transcriptase conformation); 5' vRNA end - vRNA loop (40-mer) 8psz P 13 2.42 URS0002915695_1549864 38066000 1549864 auaccaaauuuua ............. ............. Tilapia Lake Virus polymerase in vRNA elongation state with additional mode B promoter (transcriptase conformation); Transcription-like product 8psz D 14 2.42 URS000291569A_1549864 38066000 1549864 gugaguaaauuugg .............. .............. Tilapia Lake Virus polymerase in vRNA elongation state with additional mode B promoter (transcriptase conformation); 5' vRNA end - vRNA loop (40-mer) 8pt2 V 13 2.59 URS000291569A_1549864 38066000 1549864 aaaucuuucucac <<...>>...... ((...))...... Tilapia Lake Virus polymerase in vRNA pre-initiation state mode B (transcriptase conformation); 5' vRNA end - vRNA loop (40-mer) 8pt2 D 14 2.59 URS000291569A_1549864 38066000 1549864 gugaguaaauuugg .............. .............. Tilapia Lake Virus polymerase in vRNA pre-initiation state mode B (transcriptase conformation); 5' vRNA end - vRNA loop (40-mer) 8pt6 V 13 3.03 URS000291569A_1549864 38066000 1549864 aaaucuuucucac <<...>>...... ((...))...... Tilapia Lake Virus polymerase in vRNA initiation state (replicase conformation); 5' vRNA end - vRNA loop (40-mer) 8pt6 S 15 3.03 URS000291569A_1549864 38066000 1549864 gugaguaaaauuugg ............... ............... Tilapia Lake Virus polymerase in vRNA initiation state (replicase conformation); 5' vRNA end - vRNA loop (40-mer) 8pt7 V 14 2.8 URS000291567A_1549864 38066000 1549864 aaauuuuacucaca <<...>>....... ((...))....... Tilapia Lake Virus polymerase in cRNA pre-initiation state mode A (core-endo only); 5'/3' cRNA ends - cRNA loop (40-mer) 8pt7 S 15 2.8 URS000291567A_1549864 38066000 1549864 gugagaaagauuugc ............... ............... Tilapia Lake Virus polymerase in cRNA pre-initiation state mode A (core-endo only); 5'/3' cRNA ends - cRNA loop (40-mer) 8pth D 14 2.73 URS000291569A_1549864 38066000 1549864 gugaguaaauuugg .............. .............. Tilapia Lake Virus polymerase in vRNA pre-initiation state mode B (open core | partial replicase conformation); 3' vRNA end - vRNA loop (40-mer) 8pth V 13 2.73 URS000291569A_1549864 38066000 1549864 aaaucuuucucac <<...>>...... ((...))...... Tilapia Lake Virus polymerase in vRNA pre-initiation state mode B (open core | partial replicase conformation); 3' vRNA end - vRNA loop (40-mer) 8pv1 C1 3078 2.56 RF02543 URS00029156E5_759272 37921038 0003735 0005840 759272 agguugaccucggaucagguaggaggacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaacagggauugcccuaguaacggcgagugaagcggcaacagcucaaauuugaaagcuggcuucggcccgcguuguaauuuggagaggaugcuuugggcgaggcuccuucugaguucccuggaacgggacgccacagagggugagagccccguauaguuggaagccaagccuguguaaagcuccuucgacgagucgaguaguuugggaaugcugcucaaaaugggagguaaauuucuucuaaagcuaaauaccggccagagaccgauagcgcacaaguagagugaucgaaagaugaaaagcacuuugaaaagaggnuuanauagcacgugaaauuguugaaagggaagcgcuugugaccagacuugcgcccggcggaucauccgguguucucaccggugcacuccgccgggcucaggccagcaucgguucuggcggggggauaaaggcccagggaauguggcuccuccgggaguguuauagcccuggguguaauacccucgccgggaccgaggaccgcgcucugcaaggaugcuggcguaauggucaccagcgacccnucuugaaacncggaccaangagucaagguuuugcgcgaguguuuggguguaaaacccgcacgcguaaugaaagugaacguaggugagagcuucggcgcaucaucgaccgauccugauguauucggauggauuugaguaggagcguuaagcnuuggacccnaaagauggugaacuaugcuuggauagggugaagccagaggaaacucugguggaggcucgcngcgguucugncgugcaaaucgaucgucaaaucugagcaugggggcgaaagacuaaucgaaccaucuaguagcugguuaccgccgaaguuucccucaggauagcagugucgaccuucaguuuuaugagguaaagcgaaugaacuuuaaauauguaagaagcccuuguuacuuaacugaacgugggcauucgaauguaucgacacuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacgcgggguuaaggugccggaguggacgcucaucagacaccacaaaaggcguuaguacaucuugacagcaggacgguggccnuggaagucggaauccgcuaaggacuguguaacaacucaccugccgaauguacuagcccugaaaauggauggcgcucaagcgucccacccauaccccgcccucaggguagaaacgaugcccugaggaguaggcggccguggaggucagugacgaagccuagggcgugagcccgggucgaacggccucuagugcagaunuuggugguagunncaaauacuucaaugagaacuugaaggaccgaaguggggaaagguuccaugugaacagngguuggacauggguuagucgauccuaagccauagggaaguuccguuucaaaggggcacucgugccccguguggcgaaagggaagccgguuaauauuccggcaccuggauguggguuuugcgcggcaacgcaacugaacgcggagacgacggcgggggccccgggcagaguucucuuuucuucuuaacggucuaucacccuggaaacaguuugucuggagauaggguuuaauggccggaagagcccgacacuucugucggguccggugcgcucucgacgucccuugaaaauccgcgggagggaauaauucucacgccaggunguacucauaaccgcagcagguccncaaggugaacngccucugguugauagaacaanguagauaagggaagucggcaaaauagauccguaacuucgggaaaagganuggcucuaaggguugggcacgugcgugcgguuaacaaccaacuuagaacugguacggacagggggaaucugacugucuaauuaaaacauagcauugcgauggccagaaagugguguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuguagccaaanggauuaacgagnuucccacugunccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcaaaaucagcggngaaagaagacccuguugagcungacncuaguuugacauugugaaaagauuuuuuuacuuauucaaugaagcggggcuggacuugcguccaacuucuggaguuaagguccuucgcgggccgacccggguugaagacauugucagguggggaguuuggcugnggcggcacaucugugcagguguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaaguccccuugauuuugauunucagngngaauacaaaccaugaaaguguggccuaucgauccuuuagucccucgaaauuugaggcuagaggugccagaaaaguuaccacagngauggcuuguggcggccaagcguucauagcgacgucgcuuugauccuucgaugucggnucuuccuaucauaccgaagcagaauucgguaagcguungauunuucacccacuaauagggaacgugagcuggguuuagancgucgugagacagguuaguuuuacccuacugaugaacucgucgcaaugguaauucagcuuaguacgagaggaaccgcugauucagauaauugguuuuugcgguuguccgaccgggcagugccgcgaagcuaccaucugcuggauaauggcugaacgccucuaagucagaauccaugccagaacgcgacgauacuacccgcacguuguagacguauaagaauaggcuccggccucguauccuagcaggcgauuccuccgccggccucgaaguggccgucgguaauucgcguauugcaauuuagacacgcgcgggaucaaauccuuugcagacgacuuagaugugcgaaaggguccuguaagcaguagaguagccuuguuguuacgaucugcugaggguaagcccuccuucgccuagauuuc ...........................<<<<<<.....<...<..>......>>>>>.>.........<<....>>..<<<<<......<<.>...>>.....>>>>>..<<<..<<.......<<.<<<....>>>.>>.......>>....<<<<<.<<<<<<<<<..<<<<<<..<<<...<<<<......>>>>.((......<<<.....))>>>.>..>>..>>.>>>>..>>>>....>>>>>>>>.>>........<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<.<<<<<<.<...<<.<<<<<<<<<.....<<<<<<....>>>>>>......>>>>>>>>>.>>.<<<<<<<.<<<<<<<<<<<<<<<.......<<<<<<<<......<<<<<....>>>>>.......>>>>>>>>......>>>>>>>>>>>>>>>........<<...>>.....>>>>>>>....>>>>>>>.>>>>..<<<<.<....>.>>>><<<<<<...<<<<<<<<<.<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<....>>...>>>>>.<<<<<<<<...<<....>>...>>>>.>>.>>....>>>>.>>>>>>>>>.<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>...<<<<<......<<<....>>>..<<<<<<<<<.....<<.<<<<<<<.....<<<........>>.>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>...>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<......<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>....>>>>>>.>>>...>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<..<<<....>>>........<<<<<......>>>>>...>>>>....>>...<<<<<........>>>>>))<<<<.<<<<.<<<....<<<....>>>...<.((<<<<<<...<<<<.<<<<<<<.<<<<<.<<<<...[[..>>>>.><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>...>.....>>>...>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<.<<<<<..>>>>>......>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>.........<<.<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>.<<<<<<.......>>>>>>......<<..>>......>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<........<<<<<.<<<<<<..<<<<<.<<<<<<<<..<<<<<<<<..>>>>>>>>...<<<<<.....<<<<..<<<<<....>>>>>..........))..<<<<<.....>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>.......<<<<<<.<<<<<<....>>>>>>>>...<<<<<<<...<<<<<<.......>>>>>>.....<<......>>....>>>>>>>....<<<<.<.<<<.....>>>.>>>>>.<<<....>>>..>>>>.<<...<<<<<<<..<<<<.))))))>>>>>>>>>>>.....>>..>>>>..>>>>>>>.........<<<<<<...<<.......>>...>>>>>>...............<<<<..<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>......>>>>......<<<<<<<....>>>.>>>>........>>>.>>>>>....<<<<<<<..<<<<.<.<<<<<.................>>>>>.><<<<<...<<<<....<<<<<<<<<<]]..>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>.....<<<<<.<<.<<<......<<.......<<<....>>>....>>........<<<<.....<<<.<<<<<.......>>>>>.>>>....>>>>..............>>>>>.>>>>>...<<<<<<<.............>>....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>..>>>>>...>>>>>. ...........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.(((....))).))....)........(((((.(((((((((..((((((..((..({((((......)))))[[(...).(((....}]])))....))..)).))))..))))....)))))))).))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((.(((((((....((.((((((((((....((((((....)))))).....)))))))))).)).(((((((((((((((((((((((.......((((((((......(((((....))))).......))))))))......)))))))))))))))........((...))....))))))))....))))))).))))..((((........))))((((((..(.((((((((.((((..(((...(((.......)))...)))...((....)).......(((((..((....))...))))).((((((((....(....)....))).))).))....)))).))))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)A)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).)))..(((((......(((....)))..(((((((((.....((.(((((((.....(((........)).).....)))))...((((..(((.(......))))..)))).....))))...))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(....<.....(((.((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((..(((((((...((.....)).))))))....[[(((.((...(((...(((....)))........(((((......)))))....)))....))...(((((........)))))]]((((..(((((((...((((....)))...(.[.((((((...((((.(((((((((((((.((((...{{..)))).)(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....))).).))).)))).))).))).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((.(((((..)))))......)))))..)))))).))(...).......(((((((((.a.((.........))...(((((((....((((.....))))......))))))).].......((.((((((.(...((.....((((....)))).....)).)))))..)))).((((((.......))))))......((..))......)).))))))).)..))).)))))))..))))))....)).[..(((((......].)))))....(((((..((((.......(((((.((((((..(((((.((((((((..((.(((((()))))).))....((((.....((((..(((((....)))))...........]..(((((.....)))))..))))..))))......))))))))..))))).......((((((.((((((....))))))))...(((((((.(.((((((.......))))))...).((......))....)))))))....((((.(.(((.....))).)))))((((....))).))))).(((..(((((((..((((.]]]]]])))))))))))...).))..))))..)))))))...>[....((((((...((.......))...))))))...............(((...(((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..]....)))......(((((((....))).))))..>..)..))).)))))....(((((((..(((..(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...))))..)))....))))))).....(((((.((.(((....(.((.......(((....)))....))).......((((.....(((.(((((.......))))).)))....))))..............))))).)))))...(((((((..(.......)..))..(.(((((((((.(((....((((.(..(((.((..)..).)))..)))))...)))....))))..))))))..))))). Chaetomium thermophilum pre-60S State 6 - pre-5S rotation - L1 intermediate - composite structure; 26S rRNA 8pv1 C2 156 2.56 RF00002 URS000029C274_759272 37921038 0003735 0005840 759272 aaacuuucaacaacggaucucuugguucuggcaucgaugaagaacgcagcgaaaugcgauaaguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgcccgccgguauuccggcgggcaugccuguucgagcgucau .........................................<<<<<<<<<....>>>>.....<.<<<......>>..............>>>..>...>>>....<<.....>><<<<<<<<<....>>>>>>>>>................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))................... Chaetomium thermophilum pre-60S State 6 - pre-5S rotation - L1 intermediate - composite structure; 5.8S rRNA 8pv2 C1 3056 2.63 RF02543 URS00029156B2_759272 37921038 0003735 0005840 759272 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........................<<<<<<.....<...<..>......>>>>>.>...[.....<<....>>..<<<<<......<<.>...>>.....>>>>>..<<<..<<.......<<.<<<....>>>.>>.......>>....<<<<<.<<<<<<<<<..<<<<<<..<<<...<<<<......>>>>.((......<<<.....))>>>.>..>>..>>.>>>>..>>>>....>>>>>>>>.>>........<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>....].............................<<....>>...............<<<<....>>>>..................................<<<<.<<<<<<.<...<<.<<<<<<<<<.....<<<<<<....>>>>>>......>>>>>>>>>.>>.<<<<<<<.<<<<<<<<<<<<<<<.......<<<<<<<<......<<<<<....>>>>>.......>>>>>>>>......>>>>>>>>>>>>>>>........<<...>>.....>>>>>>>....>>>>>>>.>>>>..<<<<.<....>.>>>><<<<<<...<<<<<<<<<.<<<<..<<<..<<<<<.....>>>>>..>>>...<<....>>.......<<<<<..<<....>>...>>>>>.<<<<<<<<...<<....>>...>>>>.>>.>>....>>>>.>>>>>>>>>.<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>...<<<<<......<<<....>>>..<<<<<<<<<.....<<.<<<<<<<.....<<<........>>.>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>...>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<......<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>....>>>>>>.>>>...>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<..<<<....>>>........<<<<<..>>>>>...>>>>....>>...<<<<<........>>>>>))<<<<.<<<<.<<<....<<<....>>>.....((<<<<<<...<<<<.<<<<<<<.<<<<<.<<<<...[[..>>>>.><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>.........>>>...>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<.<<<<<<<<<<<....>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>.........<<.<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>.<<<<<<.......>>>>>>......<<..>>......>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<........<<<<<.<<<<<<..<<<<<.<<<<<<<<..<<<<<<<<..>>>>>>>>...<<<<<.....<<<<..<<<<<....>>>>>..........))..<<<<<.....>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>.......<<<<<<.<<<<<<....>>>>>>>>...<<<<<<<...<<<<<<.......>>>>>>.....<<......>>....>>>>>>>....<<<<.<.<<<.....>>>.>>>>><<<<....>>>.>>>>>.<<...<<<<<<<..<<<<.))))))>>>>>>>>>>>.....>>..>>>>..>>>>>>>.........<<<<<<...<<.......>>...>>>>>>...............<<<<...<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>.......>>>>......<<<<<<<....>>>.>>>>........>>>.>>>>>....<<<<<<<..<<<<.<.<<<<<.................>>>>>.><<<<<...<<<<....<<<<<<<<<<]]..>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>.....<<<<<.<<.<<<......<<.......<<<....>>>....>>........<<<<.....<<<.<<<<<.......>>>>>.>>>....>>>>..............>>>>>.>>>>>...<<<<<<<.............>>....<<<<<<<<<.<<<....<<<<.<..<<<<<......>>>>>..>>>>>...>>>....>>>>..>>>>>...>>>>>. 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Chaetomium thermophilum pre-60S State 10 - pre-5S rotation with Ytm1-Erb1; 26S rRNA 8pv2 C2 153 2.63 RF00002 URS000029C274_759272 37921038 0003735 0005840 759272 aaacuuucaacaacggaucucuugguucuggcaucgaugaagaacgcagcgaaaugcgauaaguaaugugaauugcagaaugugaaucaucgaaucuuugaacgcacauugcgcccgccgguauuccggcgggcaugccuguucgagcgucau .........................................<<<<<<<<<....>>>>.....<.<<<......>>...........>>>..>...>>>....<<.....>><<<<<<<<<....>>>>>>>>>................... .........................................((((((.[[.....))).....(.((((.....]].........).)))..)...)))....((.....))(((((((((....)))))))))................... Chaetomium thermophilum pre-60S State 10 - pre-5S rotation with Ytm1-Erb1; 5.8S rRNA 8pv3 C1 2998 2.8 RF02543 URS00029156E5_759272 37921038 0003735 0005840 759272 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...........................<<<<<<.....<...<..>......>>>>>.>...[.....<<....>>..<<<<<......<<.>...>>.....>>>>>..<<<..<<.......<<.<<<....>>>.>>.......>>....<<<<<.<<<<<<<<<..<<<<<<..<<<...<<<<......>>>>.((......<<<.....))>>>.>..>>..>>.>>>>..>>>>....>>>>>>>>.>>........<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>....].............................<<....>>...............<<<<....>>>>..................................<<<<.<<<<<<.<...<<.<<<<<<<<<.....<<<<<<....>>>>>>......>>>>>>>>>.>>.<<<<<<<.<<<<<<<<<<<<<<<.......<<<<<<<<......<<<<<....>>>>>.......>>>>>>>>......>>>>>>>>>>>>>>>........<<...>>.....>>>>>>>....>>>>>>>.>>>>..<<<<.<....>.>>>><<<<<<...<<<<<<<<<.<<<<..<<<..<<<<<.....>>>>>..>>>...<<....>>.......<<<<<..<<....>>...>>>>>.<<<<<<<<...<<....>>...>>>>.>>.>>....>>>>.>>>>>>>>>.<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>...<<<<<......<<<....>>>..<<<<<<<<<.....<<.<<<<<<<.....<<<........>>.>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>...>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<......<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>....>>>>>>.>>>...>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>.<<<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>.>>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<..<<<....>>>........<<<<<......>>>>>...>>>>....>>...<<<<<........>>>>>))<<<<.<<<<.<<<....<<<....>>>...<.{.<<<<<<...<<<<.<<<<<<<.<<<<<.<<<<...[[..>>>>.><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>...>.....>>>...>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<....<....>.....>>>>><<.<<<<<<<<<<<.<<<<<..>>>>>......>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...........<<..>>......>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<........<<<<<.<<<<<<..<<<<<.<<<<<<<<..<<<<<<..>>>>>>...<<<<<.....<<<<..<<<<<....>>>>>...........}..<<<<<.....>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>.......<<<<<<.<<<<<<....>>>>>>>>...<<<<<<<...<<<<<<.......>>>>>>.....<<......>>....>>>>>>>....<<<<.<.<<<.....>>>.>>>>>.<<<....>>>..>>>>.<<...<<<<<<<..<<<<.))))))>>>>>>>>>>>.....>>..>>>>..>>>>>>>.........<<<<<<...<<.......>>...>>>>>>...............<<<<...<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>.......>>>>......<<<<<<<....>>>.>>>>........>>>.>>>>>....<<<<<<<..<<<<.<.<<<<<.................>>>>>.><<<<<...<<<<....<<<<<<<<<<]]..>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>.....<<<<<.<<.<<<......<<.......<<<<..>>>>....>>........<<<<.....<<<.<<<<<.......>>>>>.>>>....>>>>..............>>>>>.>>>>>...<<<<<<<.............>>....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>..>>>>>...>>>>>. ...........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.(((....))).))....)........(((((.(((((((((..((((((..((..({((((......)))))[[(...).(((....}]])))....))..)).))))..))))....)))))))).))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((.(((((((....((.((((((((((....((((((....)))))).....)))))))))).)).(((((((((((((((((((((((.......((((((((......(((((....))))).......))))))))......)))))))))))))))........((...))....))))))))....))))))).))))..((((........))))((((((..(.((((((((.((((..(((...(((.......)))...)))...((....)).......(((((..((....))...))))).((((((((....(....)....))).))).))....)))).))))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)A)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).)))..(((((......(((....)))..(((((((((.....((.(((((((.....(((........)).).....)))))...((((..(((.(......))))..)))).....))))...))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(....<.....(((.((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((..(((((((...((.....)).))))))....[[(((.((...(((...(((....)))........(((((......)))))....)))....))...(((((........)))))]]((((..(((((((...((((....)))...(.[.((((((...((((.(((((((((((((.((((...{{..)))).)(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....))).).))).)))).))).))).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((.(((((..)))))......)))))..)))))).))(...).......(((((((((.a.((.........))...(((((((....((((.....))))......))))))).].........((..))......)).))))))).)..))).)))))))..))))))....)).[..(((((......].)))))....(((((..((((.......(((((.((((((..(((((.((((((((..((.(((()))).))....((((.....((((..(((((....)))))...........]..(((((.....)))))..))))..))))......))))))))..))))).......((((((.((((((....))))))))...(((((((.(.((((((.......))))))...).((......))....)))))))....((((.(.(((.....))).)))))((((....))).))))).(((..(((((((..((((.]]]]]])))))))))))...).))..))))..)))))))...>[....((((((...((.......))...))))))...............(((...(((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..]....)))......(((((((....))).))))..>..)..))).)))))....(((((((..(((..(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...))))..)))....))))))).....(((((.((.(((....(.((.......(((....)))....))).......((((.....(((.(((((.......))))).)))....))))..............))))).)))))...(((((((..(.......)..))..(.(((((((((.(((....((((.(..(((.((..)..).)))..)))))...)))....))))..))))))..))))). Chaetomium thermophilum pre-60S State 9 - pre-5S rotation - immature H68/H69 - composite structure; 26S rRNA 8pv3 C2 156 2.8 RF00002 URS000029C274_759272 37921038 0003735 0005840 759272 aaacuuucaacaacggaucucuugguucuggcaucgaugaagaacgcagcgaaaugcgauaaguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgcccgccgguauuccggcgggcaugccuguucgagcgucau .........................................<<<<<<<<<....>>>>.....<.<<<......>>..............>>>..>...>>>....<<.....>><<<<<<<<<....>>>>>>>>>................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))................... Chaetomium thermophilum pre-60S State 9 - pre-5S rotation - immature H68/H69 - composite structure; 5.8S rRNA 8pv4 C1 3136 2.9 RF02543 URS00029156E5_759272 37921038 0003735 0005840 759272 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...........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.(((....))).))....)........(((((.(((((((((..((((((..((..({((((......)))))[[(...).(((....}]])))....))..)).))))..))))....)))))))).))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((.(((((((....((.((((((((((....((((((....)))))).....)))))))))).)).(((((((((((((((((((((((.......((((((((......(((((....))))).......))))))))......)))))))))))))))........((...))....))))))))....))))))).))))..((((........))))((((((..(.((((((((.((((..(((...(((.......)))...)))...((....)).......(((((..((....))...))))).((((((((....(....)....))).))).))....)))).))))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)A)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).)))..(((((......(((....)))..(((((((((.....((.(((((((.....(((........)).).....)))))...((((..(((.(......))))..)))).....))))...))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(....<.....(((.((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((..(((((((...((.....)).))))))....[[(((.((...(((...(((....)))........(((((......)))))....)))....))...(((((........)))))]]((((..(((((((...((((....)))...(.[.((((((...((((.(((((((((((((.((((...{{..)))).)(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....))).).))).)))).))).))).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((.(((((..)))))......)))))..)))))).))(...).......(((((((((.a.((.........))...(((((((....((((.....))))......))))))).].......((.((((((.(...((.....((((....)))).....)).)))))..)))).((((((.(...).))))))......((..))......)).))))))).)..))).)))))))..))))))....)).[..(((((......].)))))....(((((..((((.......(((((.((((((..(((((.((((((((..(((((((((((((((((..........(((((..((....))............))))).))))))).))))))))))...(((((.....((((..(((((....)))))...........]..(((((.....)))))..))))..))))).....))))))))..))))).......((((((.((((((....))))))))...(((((((.(.((((((.......))))))...).((......))....)))))))....((((.(.(((.....))).)))))((((....))).))))).(((..(((((((..((((.]]]]]])))))))))))...).))..))))..)))))))...>[....((((((...((.......))...))))))...............(((...(((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..]..)))......(((((((....))).))))..>..)..))).)))))....(((((((..(((..(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...))))..)))....))))))).....(((((.((.(((....(.((.......(((....)))....))).......((((.....(((.(((((.......))))).)))....))))..............))))).)))))...(((((((..(.......)..))..(.(((((((((.(((....((((.(..(((.((..)..).)))..)))))...)))....))))..))))))..))))). Chaetomium thermophilum pre-60S State 2 - pre-5S rotation with Rix1 complex - composite structure; 26S rRNA 8pv4 C2 156 2.9 RF00002 URS000029C274_759272 37921038 0003735 0005840 759272 aaacuuucaacaacggaucucuugguucuggcaucgaugaagaacgcagcgaaaugcgauaaguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgcccgccgguauuccggcgggcaugccuguucgagcgucau .........................................<<<<<<<<<....>>>>.....<.<<<......>>..............>>>..>...>>>....<<.....>><<<<<<<<<....>>>>>>>>>................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))................... Chaetomium thermophilum pre-60S State 2 - pre-5S rotation with Rix1 complex - composite structure; 5.8S rRNA 8pv5 C1 3060 2.86 RF02543 URS00029156E5_759272 37921038 0003735 0005840 759272 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Chaetomium thermophilum pre-60S State 8 - pre-5S rotation without Foot - composite structure; 26S rRNA 8pv5 C2 152 2.86 RF00002 URS000029C274_759272 37921038 0003735 0005840 759272 aaacuuucaacaacggaucucuugguucuggcaucgaugaagaacgcagcgaaaugcgauaaguaaugugaauugcagaagugaaucaucgaaucuuugaacgcacauugcgcccgccgguauuccggcgggcaugccuguucgagcgucau .........................................<<<<<<<((....>>>>.....<.<<<<.....))........>.>>>..>...>>>....<<.....>><<<<<<<<<....>>>>>>>>>................... .........................................((((((.[[.....))).....(.((((.....]]........).)))..)...)))....((.....))(((((((((....)))))))))................... Chaetomium thermophilum pre-60S State 8 - pre-5S rotation without Foot - composite structure; 5.8S rRNA 8pv6 C1 3100 2.94 RF02543 URS00029156E5_759272 37921038 0003735 0005840 759272 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...........................<<<<<<.....<......>......>>>>>.>...<.....<<....>>..<<<<<......<<.....>>.....>>>>>..<<<..<<.......<<.<<<....>>>.>>.......>>....<<<<<.<<<<<<<<<..<<<<<<..<<<...<<<<......>>>>.((......<<<.....))>>>.>..>>..>>>.>>>..>>>>....>>>>>>>>.>>........<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>....>.............................<<....>>...............<<<<....>>>>..................................<<<<.<<<<<<.<...<<.<<<<<<<<<.....<<<<<<....>>>>>>......>>>>>>>>>.>>.<<<<<<<.<<<<<<<<<<<<<<<.......<<<<<<<<......<<<<<....>>>>>.......>>>>>>>>......>>>>>>>>>>>>>>>........<<...>>.....>>>>>>>....>>>>>>>.>>>>..<<<<........>>>><<<<<<...<<<<<<<<<.<<<<..<<<..<<<<<.....>>>>>..>>>...<<....>>.......<<<<<..<<....>>...>>>>>.<<<<<<<<...<<....>>...>>>>.>>.>>....>>>>.>>>>>>>>>.<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>...<<<<<......<<..>>..<<<<<<<<<.....<<.<<<<<<<.........<<....<<<...<<<<<..>>>>>.>>>..>>..>>>>>...<<<<.<<<<.<......>>>>>.>>>>.>>>>.>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>...>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<...<<<....>>>........<<<<<......>>>>>.>>>....>>...<<<<<........>>>>>))<<<<.<<<<.<<<....<<<....>>>...<..{<<<<<<...<<<<.<<<<<<<.<<<<<.<<<<...[[..>>>>.><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>...>.....>>>...>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<.<<<<<<<<<<<.<<<<<..>>>>>......>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>......<<<..<<<<<<..<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>..........>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<........<<<<<.<<<<<<..<<<<<.<<<<<<<<..<<<<<<<<<<<<<<<<<..........<<<<<..<<....>>............>>>>>.>>>>>>>.>>>>>>>>>>...<<<<<.....<<<<..<<<<<....>>>>>..........}...<<<<<.....>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<.<<<<<<..>>>>>>>>...<<<<<<<...<<<<<<.......>>>>>>.....<<....((>>....>>>>>>>...<<<.<<<<<....>>>>.>>>>.<<<....>>>...))<<<<<<<..<<<<.))))))>>>>>>>>>>>.>>>>..>>>>>>>.........<<<<<<...<<.......>>...>>>>>>...............<<<<...<<<<..<.<<<<<<<......>>>>>>>...>.<<<.<...>.>>>.....>>>>.....>>>>......<<<<<<<....>>>.>>>>........>>>.>>>>>....<<<<<<<..<<<<.<.<<<<<.................>>>>>.><<<<<...<<<<....<<<<<<<<<<]]..>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>.....<<<<<.<<.<<<......<<.......<<<....>>>....>>........<<<<.....<<<.<<<<<.......>>>>>.>>>....>>>>..............>>>>>.>>>>>...<<<<<<<.............>>....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>..>>>>>...>>>>>. 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Chaetomium thermophilum pre-60S State 3 - post-5S rotation with Rix1 complex with Foot - composite structure; 26S rRNA 8pv6 C2 156 2.94 RF00002 URS000029C274_759272 37921038 0003735 0005840 759272 aaacuuucaacaacggaucucuugguucuggcaucgaugaagaacgcagcgaaaugcgauaaguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgcccgccgguauuccggcgggcaugccuguucgagcgucau .........................................<<<<<<<<<....>>>>.....<.<<<......>>..............>>>..>...>>>....<<.....>><<<<<<<<<....>>>>>>>>>................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))................... Chaetomium thermophilum pre-60S State 3 - post-5S rotation with Rix1 complex with Foot - composite structure; 5.8S rRNA 8pv6 C4 115 2.94 RF00001 URS0002617727_759272 37921038 0003735 0005840 759272 acguacgaccauacccaguggaaagcacggcaucccguccgcucugcccuaguuaagccacugagggcccgguuaguaguugggucgggaccagcgaaucccggguguuguacgu <<<<<<<<<....<<<<<<<<.....<<<<<<............>>>>...>>....>>>>>>.>><<<<<<......<<<<<.......>>>>>.....>>>>>>>>>>>>>>> (((((((((....((((((((.....((((((...(....)...))))...))....)))))).))((((((......(((((..(..).))))).....))))))))))))))) Chaetomium thermophilum pre-60S State 3 - post-5S rotation with Rix1 complex with Foot - composite structure; 5S rRNA 8pv7 C1 3078 2.12 RF02543 URS00029156E5_759272 37921038 0003735 0005840 759272 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...........................<<<<<<.....<...<..>......>>>>>.>...[.....<<....>>..<<<<<......<<.>...>>.....>>>>>..<<<..<<.......<<.<<<....>>>.>>.......>>....<<<<<.<<<<<<<<<..<<<<<<..<<<...<<<<......>>>>.((......<<<.....))>>>.>..>>..>>.>>>>..>>>>....>>>>>>>>.>>........<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>....].............................<<....>>...............<<<<....>>>>..................................<<<<.<<<<<<.<...<<.<<<<<<<<<.....<<<<<<....>>>>>>......>>>>>>>>>.>>.<<<<<<<.<<<<<<<<<<<<<<<.......<<<<<<<<......<<<<<....>>>>>.......>>>>>>>>......>>>>>>>>>>>>>>>........<<...>>.....>>>>>>>....>>>>>>>.>>>>..<<<<.<....>.>>>><<<<<<...<<<<<<<<<.<<<<..<<<..<<<<<.....>>>>>..>>>...<<....>>.......<<<<<..<<....>>...>>>>>.<<<<<<<<...<<....>>...>>>>.>>.>>....>>>>.>>>>>>>>>.<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>...<<<<<......<<<....>>>..<<<<<<<<<.....<<.<<<<<<<.....<<<........>>.>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>...>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<......<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>....>>>>>>.>>>...>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<..<<<....>>>........<<<<<......>>>>>...>>>>....>>...<<<<<........>>>>>))<<<<.<<<<.<<<....<<<....>>>...<.((<<<<<<...<<<<.<<<<<<<.<<<<<.<<<<...[[..>>>>.><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>...>.....>>>...>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<.....<..>......>>>>><<.<<<<<<<<<<<.<<<<<..>>>>>......>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>.........<<.<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>.<<<<<<.......>>>>>>......<<..>>......>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<........<<<<<.<<<<<<..<<<<<.<<<<<<<<..<<<<<<<<..>>>>>>>>...<<<<<.....<<<<..<<<<<....>>>>>..........))..<<<<<.....>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>.......<<<<<<.<<<<<<....>>>>>>>>...<<<<<<<...<<<<<<.......>>>>>>.....<<......>>....>>>>>>>....<<<<...<<<.....>>>..>>>>.<<<....>>>..>>>>.<<...<<<<<<<..<<<<.))))))>>>>>>>>>>>.....>>..>>>>..>>>>>>>.........<<<<<<...<<.......>>...>>>>>>...............<<<<..<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>......>>>>......<<<<<<<....>>>.>>>>........>>>.>>>>>....<<<<<<<..<<<<.<.<<<<<.................>>>>>.><<<<<...<<<<....<<<<<<<<<<]]..>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>.....<<<<<.<<.<<<......<<.......<<<....>>>....>>........<<<<.....<<<.<<<<<.......>>>>>.>>>....>>>>..............>>>>>.>>>>>...<<<<<<<.............>>....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>..>>>>>...>>>>>. ...........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.(((....))).))....)........(((((.(((((((((..((((((..((..({((((......)))))[[(...).(((....}]])))....))..)).))))..))))....)))))))).))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((.(((((((....((.((((((((((....((((((....)))))).....)))))))))).)).(((((((((((((((((((((((.......((((((((......(((((....))))).......))))))))......)))))))))))))))........((...))....))))))))....))))))).))))..((((........))))((((((..(.((((((((.((((..(((...(((.......)))...)))...((....)).......(((((..((....))...))))).((((((((....(....)....))).))).))....)))).))))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)A)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).)))..(((((......(((....)))..(((((((((.....((.(((((((.....(((........)).).....)))))...((((..(((.(......))))..)))).....))))...))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(....<.....(((.((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((..(((((((...((.....)).))))))....[[(((.((...(((...(((....)))........(((((......)))))....)))....))...(((((........)))))]]((((..(((((((...((((....)))...(.[.((((((...((((.(((((((((((((.((((...{{..)))).)(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....))).).))).)))).))).))).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((.(((((..)))))......)))))..)))))).))(...).......(((((((((.a.((.........))...(((((((....((((.....))))......))))))).].......((.((((((.(...((.....((((....)))).....)).)))))..)))).((((((.......))))))......((..))......)).))))))).)..))).)))))))..))))))....)).[..(((((......].)))))....(((((..((((.......(((((.((((((..(((((.((((((((..((.(((((()))))).))....((((.....((((..(((((....)))))...........]..(((((.....)))))..))))..))))......))))))))..))))).......((((((.((((((....))))))))...(((((((.(.((((((.......))))))...).((......))....)))))))....((((.(.(((.....))).)))))((((....))).))))).(((..(((((((..((((.]]]]]])))))))))))...).))..))))..)))))))...>[....((((((...((.......))...))))))...............(((...(((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..]....)))......(((((((....))).))))..>..)..))).)))))....(((((((..(((..(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...))))..)))....))))))).....(((((.((.(((....(.((.......(((....)))....))).......((((.....(((.(((((.......))))).)))....))))..............))))).)))))...(((((((..(.......)..))..(.(((((((((.(((....((((.(..(((.((..)..).)))..)))))...)))....))))..))))))..))))). Chaetomium thermophilum pre-60S State 1 - pre-5S rotation (Arx1/Nog2 state) - Composite structure; 26S rRNA 8pv7 C2 156 2.12 RF00002 URS000029C274_759272 37921038 0003735 0005840 759272 aaacuuucaacaacggaucucuugguucuggcaucgaugaagaacgcagcgaaaugcgauaaguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgcccgccgguauuccggcgggcaugccuguucgagcgucau .........................................<<<<<<<<<....>>>>.....<.<<<......>>..............>>>..>...>>>....<<.....>><<<<<<<<<....>>>>>>>>>................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))................... Chaetomium thermophilum pre-60S State 1 - pre-5S rotation (Arx1/Nog2 state) - Composite structure; 5.8S rRNA 8pv8 C1 3085 2.91 RF02543 URS00029156E5_759272 37921038 0003735 0005840 759272 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........................<<<<<<.....<......>......>>>>>.>...<.....<<....>>..<<<<<......<<.....>>.....>>>>>..<<<..<<.......<<.<<<....>>>.>>.......>>....<<<<<.<<<<<<<<<..<<<<<<..<<<...<<<<......>>>>.((......<<<.....))>>>.>..>>..>>>.>>>..>>>>....>>>>>>>>.>>........<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>....>.............................<<....>>...............<<<<....>>>>..................................<<<<.<<<<<<.<...<<.<<<<<<<<<.....<<<<<<....>>>>>>......>>>>>>>>>.>>.<<<<<<<.<<<<<<<<<<<<<<<.......<<<<<<<<......<<<<<....>>>>>.......>>>>>>>>......>>>>>>>>>>>>>>>........<<...>>.....>>>>>>>....>>>>>>>.>>>>..<<<<........>>>><<<<<<...<<<<<<<<<.<<<<..<<<..<<<<<.....>>>>>..>>>...<<....>>.......<<<<<..<<....>>...>>>>>.<<<<<<<<...<<....>>...>>>>.>>.>>....>>>>.>>>>>>>>>.<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>...<<<<<......<<..>>..<<<<<<<<<.....<<.<<<<<<<.........<<....<<<...<<<<<..>>>>>.>>>..>>..>>>>>...<<<<.<<<<.<......>>>>>.>>>>.>>>>.>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>...>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<<....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<...<<<....>>>........<<<<<<....>>>>>>....>>>....>>...<<<<<........>>>>>))<<<<.<<<<.<<<....<<<....>>>...<.((<<<<<<...<<<<.<<<<<<<.<<<<<.<<<<...[[..>>>>.><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>...>.....>>>...>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<....>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>......<<<..<<<<<<..<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>..........>>.>>>>>>>.....>>.>>>>>>>..>>>>>>...>>>....<<<<<........>>>>>....<<<<<..<<<........<<<<<.<<<<<<..<<<<<.<<<<<<<<..<<<<<<<<<<<<<<<<<..........<<<<<..<<....>>............>>>>>.>>>>>>>.>>>>>>>>>>...<<<<<.....<<<<..<<<<<....>>>>>..........))..<<<<<.....>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<.<<<<<<..>>>>>>>>...<<<<<<<...<<<<<<.......>>>>>>.....<<....((>>....>>>>>>>...<<<.<<<<<....>>>>.>>>>.<<<....>>>...))<<<<<<<..<<<<.))))))>>>>>>>>>>>.>>>>..>>>>>>>.........<<<<<<...<<.......>>...>>>>>>...............<<<<...<<<<..<.<<<<<<<......>>>>>>>...>.<<<.<...>.>>>.....>>>>.....>>>>......<<<<<<<....>>>.>>>>........>>>.>>>>>....<<<<<<<..<<<<.<.<<<<<.................>>>>>.><<<<<...<<<<....<<<<<<<<<<]]..>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>.....<<<<<.<<.<<<......<<.......<<<....>>>....>>........<<<<.....<<<.<<<<<.......>>>>>.>>>....>>>>..............>>>>>.>>>>>...<<<<<<<.............>>....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>..>>>>>...>>>>>. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.(((....))).))....)........(((((.(((((((((..((((((..((..({((((......)))))[[(...).(((....}]])))....))..)).))))..))))....)))))))).))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((.(((((((....((.((((((((((....((((((....)))))).....)))))))))).)).(((((((((((((((((((((((.......((((((((......(((((....))))).......))))))))......)))))))))))))))........((...))....))))))))....))))))).))))..((((........))))((((((..(.((((((((.((((..(((...(((.......)))...)))...((....)).......(((((..((....))...))))).((((((((....(....)....))).))).))....)))).))))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)A)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).)))..(((((......((()))..(((((((((.....((.(((((((.........((....(((...(.(((()))).).)))..))..)))))...((((.((((.(......))))).)))).)))).))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(....<.....(((.((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((..(((((((...((.....)).))))))....[[(((.((...(((...(((....)))........(((((......)))))....)))....))...(((((........)))))]]((((..(((((((...((((....)))...(.[[((((((...((((.(((((((((((((.((((...{{..)))).)(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....))).).))).)))).))).))).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((....)))))..)))))).))(...).......(((((((((.a.((.........))...(((((((....((((.....))))......))))))).]....(((..((((((...((.....((((....)))).....))..))))..)))))(((((.........)))))..........)).))))))).)..))).)))))))..))))))....)).[..(((((......].)))))....(((((..((((.......(((((.((((((..(((((.((((((((..(((((((((((((((((...........((((..((....))............))))..))))))).))))))))))...(((((.....((((..(((((....)))))..........]]..(((((.....)))))..))))..))))).....))))))))..)))))...((.((((((()))))))))..((((((((.(.((((((.......))))))...).((....[[))....))))))))(.(((.(((((....)))).)))))(((....)))...]](((((((..((((.]]]]]]))))))))))).))))..)))))))...>[....((((((...((.......))...))))))...............((((..(((((..(.(((((((......))))))..).).(((.(...).))).....)))))..].))))......(((((((....))).))))..>..)..))).)))))....(((((((..(((..(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...))))..)))....))))))).....(((((.((.(((....(.((.......(((....)))....))).......((((.....(((.(((((.......))))).)))....))))..............))))).)))))...(((((((..(.......)..))..(.(((((((((.(((....((((.(..(((.((..)..).)))..)))))...)))....))))..))))))..))))). Chaetomium thermophilum pre-60S State 4 - post-5S rotation with Rix1 complex without Foot - composite structure; 26S rRNA 8pv8 C2 150 2.91 RF00002 URS000029C274_759272 37921038 0003735 0005840 759272 aaacuuucaacaacggaucucuugguucuggcaucgaugaagaacgcagcgaaaugcgauaaguaaugugaauugcagaagaaucaucgaaucuuugaacgcacauugcgcccgccgguauuccggcgggcaugccuguucgagcgucau .........................................<<<<<<<<<....>>>>.....<.<<<......>>........>>>..>...>>>....<<.....>><<<<<<<<<....>>>>>>>>>................... .........................................((((((.[[.....))).....(.((((.....]]......).)))..)...)))....((.....))(((((((((....)))))))))................... Chaetomium thermophilum pre-60S State 4 - post-5S rotation with Rix1 complex without Foot - composite structure; 5.8S rRNA 8pv8 C4 115 2.91 RF00001 URS0002617727_759272 37921038 0003735 0005840 759272 acguacgaccauacccaguggaaagcacggcaucccguccgcucugcccuaguuaagccacugagggcccgguuaguaguugggucgggaccagcgaaucccggguguuguacgu <<<<<<<<<....<<<<<<<<.....<<<<<<............>>>>...>>....>>>>>>.>><<<<<<......<<<<<.......>>>>>.....>>>>>>>>>>>>>>> (((((((((....((((((((.....((((((...(....)...))))...))....)))))).))((((((......(((((..(..).))))).....))))))))))))))) Chaetomium thermophilum pre-60S State 4 - post-5S rotation with Rix1 complex without Foot - composite structure; 5S rRNA 8pva A 1519 4.5 RF00177,RF01959,RF02542,RF01960 URS00000ABFE9_562 38011573 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugccggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<........>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<.>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>...<.<<<<<.......<<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<..>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((.(........).))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((.)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((((())))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...((((((....))))))..............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Structure of bacterial ribosome determined by cryoEM at 100 keV; 16S rRNA 8pva a 2753 4.5 RF02541 URS00004B0F34_562 38011573 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagcgucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcgcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<..>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<..>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<<.<<....>>..>>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<..>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>.(<<...<<<<<<<...<<<<<<.......>>>>>>.....<<)..(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......((((.((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))).))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((((((.....))))).))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{..()....)))..))))).))...........]]].)...))))))))))...)))))))((((((((()))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....((((.((((((.((.....)))))))).)..)))...[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((())))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).).....((.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..))....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Structure of bacterial ribosome determined by cryoEM at 100 keV; 23S rRNA 8pva b 119 4.5 RF00001 URS0000049E57_562 38011573 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>> ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))) Structure of bacterial ribosome determined by cryoEM at 100 keV; 5S rRNA 8pva X 12 4.5 38011573 562 aaaaugguauaa ............ ............ Structure of bacterial ribosome determined by cryoEM at 100 keV; mRNA 8pva Y 74 4.5 RF00005 URS000009F4BF_562 38011573 0030533 0006412 562 gggugauuagcucaggggagagcaccucccuuacaaggagggggucggcgguucgaucccgucaucacccacca <<<<<<<..<<<<......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..(((....[...))).(((((.......))))).....(.(((..]....))).)))))))).... Structure of bacterial ribosome determined by cryoEM at 100 keV; A-site tRNA-val 8pva Z 76 4.5 RF00005 URS00002905B5_562 38011573 0030533 0006412 562 gcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Structure of bacterial ribosome determined by cryoEM at 100 keV; P-site tRNA-fMet 8pvk C1 3138 2.55 RF02543 URS00029156E5_759272 37921038 0003735 0005840 759272 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...........................<<<<<<.....<...<..>......>>>>>.>.........<<....>>..<<<<<......<<.>...>>.....>>>>>..<<<..<<.......<<.<<<....>>>.>>.......>>....<<<<<.<<<<<<<<<..<<<<<<..<<<...<<<<......>>>>.((......<<<.....))>>>.>..>>..>>.>>>>..>>>>....>>>>>>>>.>>........<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<.<<<<<<.<...<<.<<<<<<<<<.....<<<<<<....>>>>>>......>>>>>>>>>.>>.<<<<<<<.<<<<<<<<<<<<<<<.......<<<<<<<<......<<<<<....>>>>>.......>>>>>>>>......>>>>>>>>>>>>>>>........<<...>>.....>>>>>>>....>>>>>>>.>>>>..<<<<.<....>.>>>><<<<<<...<<<<<<<<<.<<<<..<<<..<<<<<.....>>>>>..>>>...<<....>>.......<<<<<..<<....>>...>>>>>.<<<<<<<<...<<....>>...>>>>.>>.>>....>>>>.>>>>>>>>>.<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>...<<<<<......<<<....>>>..<<<<<<<<<.....<<.<<<<<<<.....<<<........>>.>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>...>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<......<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>....>>>>>>.>>>...>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<..<<<....>>>........<<<<<......>>>>>...>>>>....>>...<<<<<........>>>>>))<<<<.<<<<.<<<....<<<....>>>...<.((<<<<<<...<<<<.<<<<<<<.<<<<<.<<<<...[[..>>>>.><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>...>.....>>>...>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<.<<<<<..>>>>>......>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>.........<<.<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>.<<<<<<.......>>>>>>......<<..>>......>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<........<<<<<.<<<<<<..<<<<<.<<<<<<<<..<<<<<<<<<<<<<<<<<..........<<<<<..<<....>>............>>>>>.>>>>>>>.>>>>>>>>>>...<<<<<.....<<<<..<<<<<....>>>>>..........))..<<<<<.....>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>.......<<<<<<.<<<<<<<..>>>>>>>>>...<<<<<<<...<<<<<<.......>>>>>>.....<<......>>....>>>>>>>....<<<<.<.<<<.....>>>.>>>>><<<<....>>>.>>>>>.<<...<<<<<<<..<<<<.))))))>>>>>>>>>>>.....>>..>>>>..>>>>>>>.........<<<<<<...<<.......>>...>>>>>>...............<<<<...<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>.......>>>>......<<<<<<<....>>>.>>>>........>>>.>>>>>....<<<<<<<..<<<<.<.<<<<<.................>>>>>.><<<<<...<<<<....<<<<<<<<<<]]..>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>.....<<<<<.<<.<<<......<<.......<<<<..>>>>....>>........<<<<.....<<<.<<<<<.......>>>>>.>>>....>>>>..............>>>>>.>>>>>...<<<<<<<.............>>....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>..>>>>>...>>>>>. ...........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.(((....))).))....)........(((((.(((((((((..((((((..((..({((((......)))))[[(...).(((....}]])))....))..)).))))..))))....)))))))).))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((.(((((((....((.((((((((((....((((((....)))))).....)))))))))).)).(((((((((((((((((((((((.......((((((((......(((((....))))).......))))))))......)))))))))))))))........((...))....))))))))....))))))).))))..((((........))))((((((..(.((((((((.((((..(((...(((.......)))...)))...((....)).......(((((..((....))...))))).((((((((....(....)....))).))).))....)))).))))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)A)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).)))..(((((......(((....)))..(((((((((.....((.(((((((.....(((........)).).....)))))...((((..(((.(......))))..)))).....))))...))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(....<.....(((.((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((..(((((((...((.....)).))))))....[[(((.((...(((...(((....)))........(((((......)))))....)))....))...(((((........)))))]]((((..(((((((...((((....)))...(.[.((((((...((((.(((((((((((((.((((...{{..)))).)(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....))).).))).)))).))).))).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((.(((((..)))))......)))))..)))))).))(...).......(((((((((.a.((.........))...(((((((....((((.....))))......))))))).].......((.((.(((.(...((.....((((....)))).....)).))))...)))).((((((.......))))))......((..))......)).))))))).)..))).)))))))..))))))....)).[..(((((......].)))))....(((((..((((.......(((((.((((((..(((((.((((((((..(((((((((((((((((...........((((..((....))............))))..))))))).))))))))))....((((.....((((..(((((....)))))...........]..(((((.....)))))..))))..))))......))))))))..))))).......((((((.(((((((())))))))))...(((((((.(.((((((.......))))))...).((......))....)))))))....((((.(.(((.....))).)))))((((....))).))))).(((..(((((((..((((.]]]]]])))))))))))...).))..))))..)))))))...>[....((((((...((.......))...))))))...............(((...(((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..]....)))......(((((((....))).))))..>..)..))).)))))....(((((((..(((..(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...))))..)))....))))))).....(((((.((.(((....(.((.......(((....)))....))).......((((.....(((.(((((.......))))).)))....))))..............))))).)))))...(((((((..(.......)..))..(.(((((((((.(((....((((.(..(((.((..)..).)))..)))))...)))....))))..))))))..))))). Chaetomium thermophilum pre-60S State 5 - pre-5S rotation - L1 inward - composite structure; 26S rRNA 8pvk C2 156 2.55 RF00002 URS000029C274_759272 37921038 0003735 0005840 759272 aaacuuucaacaacggaucucuugguucuggcaucgaugaagaacgcagcgaaaugcgauaaguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgcccgccgguauuccggcgggcaugccuguucgagcgucau .........................................<<<<<<<<<....>>>>.....<.<<<......>>..............>>>..>...>>>....<<.....>><<<<<<<<<....>>>>>>>>>................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))................... Chaetomium thermophilum pre-60S State 5 - pre-5S rotation - L1 inward - composite structure; 5.8S rRNA 8pvk C4 119 2.55 RF00001 URS0002617727_759272 37921038 0003735 0005840 759272 acguacgaccauacccaguggaaagcacggcaucccguccgcucugcccuaguuaagccacugagggcccgguuaguaguugggucggugacgaccagcgaaucccggguguuguacgu <<<<<<<<<....<<<<<<<<.....<<<<<<............>>>>...>>....>>>>>>.>><<<<<<......<<<<.<<<<....>>>>>>>>.....>>>>>>>>>>>>>>> (((((((((....((((((((.....((((((...(....)...))))...))....)))))).))((((((......((((.((((....)))))))).....))))))))))))))) Chaetomium thermophilum pre-60S State 5 - pre-5S rotation - L1 inward - composite structure; 5S rRNA 8pvl C1 3078 2.19 RF02543 URS00029156E5_759272 37921038 0003735 0005840 759272 agguugaccucggaucagguaggaggacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaacagggauugcccuaguaacggcgagugaagcggcaacagcucaaauuugaaagcuggcuucggcccgcguuguaauuuggagaggaugcuuugggcgaggcuccuucugaguucccuggaacgggacgccacagagggugagagccccguauaguuggaagccaagccuguguaaagcuccuucgacgagucgaguaguuugggaaugcugcucaaaaugggagguaaauuucuucuaaagcuaaauaccggccagagaccgauagcgcacaaguagagugaucgaaagaugaaaagcacuuugaaaagaggnuuanauagcacgugaaauuguugaaagggaagcgcuugugaccagacuugcgcccggcggaucauccgguguucucaccggugcacuccgccgggcucaggccagcaucgguucuggcggggggauaaaggcccagggaauguggcuccuccgggaguguuauagcccuggguguaauacccucgccgggaccgaggaccgcgcucugcaaggaugcuggcguaauggucaccagcgacccnucuugaaacncggaccaangagucaagguuuugcgcgaguguuuggguguaaaacccgcacgcguaaugaaagugaacguaggugagagcuucggcgcaucaucgaccgauccugauguauucggauggauuugaguaggagcguuaagcnuuggacccnaaagauggugaacuaugcuuggauagggugaagccagaggaaacucugguggaggcucgcngcgguucugncgugcaaaucgaucgucaaaucugagcaugggggcgaaagacuaaucgaaccaucuaguagcugguuaccgccgaaguuucccucaggauagcagugucgaccuucaguuuuaugagguaaagcgaaugaacuuuaaauauguaagaagcccuuguuacuuaacugaacgugggcauucgaauguaucgacacuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacgcgggguuaaggugccggaguggacgcucaucagacaccacaaaaggcguuaguacaucuugacagcaggacgguggccnuggaagucggaauccgcuaaggacuguguaacaacucaccugccgaauguacuagcccugaaaauggauggcgcucaagcgucccacccauaccccgcccucaggguagaaacgaugcccugaggaguaggcggccguggaggucagugacgaagccuagggcgugagcccgggucgaacggccucuagugcagaunuuggugguagunncaaauacuucaaugagaacuugaaggaccgaaguggggaaagguuccaugugaacagngguuggacauggguuagucgauccuaagccauagggaaguuccguuucaaaggggcacucgugccccguguggcgaaagggaagccgguuaauauuccggcaccuggauguggguuuugcgcggcaacgcaacugaacgcggagacgacggcgggggccccgggcagaguucucuuuucuucuuaacggucuaucacccuggaaacaguuugucuggagauaggguuuaauggccggaagagcccgacacuucugucggguccggugcgcucucgacgucccuugaaaauccgcgggagggaauaauucucacgccaggunguacucauaaccgcagcagguccncaaggugaacngccucugguugauagaacaanguagauaagggaagucggcaaaauagauccguaacuucgggaaaagganuggcucuaaggguugggcacgugcgugcgguuaacaaccaacuuagaacugguacggacagggggaaucugacugucuaauuaaaacauagcauugcgauggccagaaagugguguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuguagccaaanggauuaacgagnuucccacugunccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcaaaaucagcggngaaagaagacccuguugagcungacncuaguuugacauugugaaaagauuuuuuuacuuauucaaugaagcggggcuggacuugcguccaacuucuggaguuaagguccuucgcgggccgacccggguugaagacauugucagguggggaguuuggcugnggcggcacaucugugcagguguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaaguccccuugauuuugauunucagngngaauacaaaccaugaaaguguggccuaucgauccuuuagucccucgaaauuugaggcuagaggugccagaaaaguuaccacagngauggcuuguggcggccaagcguucauagcgacgucgcuuugauccuucgaugucggnucuuccuaucauaccgaagcagaauucgguaagcguungauunuucacccacuaauagggaacgugagcuggguuuagancgucgugagacagguuaguuuuacccuacugaugaacucgucgcaaugguaauucagcuuaguacgagaggaaccgcugauucagauaauugguuuuugcgguuguccgaccgggcagugccgcgaagcuaccaucugcuggauaauggcugaacgccucuaagucagaauccaugccagaacgcgacgauacuacccgcacguuguagacguauaagaauaggcuccggccucguauccuagcaggcgauuccuccgccggccucgaaguggccgucgguaauucgcguauugcaauuuagacacgcgcgggaucaaauccuuugcagacgacuuagaugugcgaaaggguccuguaagcaguagaguagccuuguuguuacgaucugcugaggguaagcccuccuucgccuagauuuc ...........................<<<<<<.....<...<..>......>>>>>.>.........<<....>>..<<<<<......<<.>...>>.....>>>>>..<<<..<<.......<<.<<<....>>>.>>.......>>....<<<<<.<<<<<<<<<..<<<<<<..<<<...<<<<......>>>>.((......<<<.....))>>>.>..>>..>>.>>>>..>>>>....>>>>>>>>.>>........<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<.<<<<<<.<...<<.<<<<<<<<<.....<<<<<<....>>>>>>......>>>>>>>>>.>>.<<<<<<<.<<<<<<<<<<<<<<<.......<<<<<<<<......<<<<<....>>>>>.......>>>>>>>>......>>>>>>>>>>>>>>>........<<...>>.....>>>>>>>....>>>>>>>.>>>>..<<<<.<....>.>>>><<<<<<...<<<<<<<<<.<<<<..<<<..<<<<<.....>>>>>..>>>...<<....>>.......<<<<<..<<....>>...>>>>>.<<<<<<<<...<<....>>...>>>>.>>.>>....>>>>.>>>>>>>>>.<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>...<<<<<......<<<.{..>>>..<<<<<<<<<.....<<.<<<<<<<.....<<<........>>.>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>...>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<......<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>....>>>>>>.>>>...>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<..<<<....>>>........<<<<<......>>>>>...>>>>....>>...<<<<<........>>>>>))<<<<.<<<<.<<<....<<<....>>>...<...<<<<<<...<<<<.<<<<<<<.<<<<<.<<<<...[[..>>>>.><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>...>.....>>>...>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<.<<<<<<<<<<<.<<<<<..>>>>>......>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>.........<<.<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>.<<<<<<.......>>>>>>......<<..>>......>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<........<<<<<.<<<<<<..<<<<<.<<<<<<<<..<<<<<<<<..>>>>>>>>...<<<<<.....<<<<..<<<<<....>>>>>..............<<<<<.....>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>..}....<<<<<<.<<<<<<....>>>>>>>>...<<<<<<<...<<<<<<.......>>>>>>.....<<......>>....>>>>>>>....<<<<...<<<.....>>>..>>>>.<<<....>>>..>>>>.<<...<<<<<<<..<<<<.))))))>>>>>>>>>>>.....>>..>>>>..>>>>>>>.........<<<<<<...<<.......>>...>>>>>>...............<<<<..<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>......>>>>......<<<<<<<....>>>.>>>>........>>>.>>>>>....<<<<<<<..<<<<.<.<<<<<.................>>>>>.><<<<<...<<<<....<<<<<<<<<<]]..>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>.....<<<<<.<<.<<<......<<.......<<<<..>>>>....>>........<<<<.....<<<.<<<<<.......>>>>>.>>>....>>>>..............>>>>>.>>>>>...<<<<<<<.............>>....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>..>>>>>...>>>>>. ...........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.(((....))).))....)........(((((.(((((((((..((((((..((..({((((......)))))[[(...).(((....}]])))....))..)).))))..))))....)))))))).))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((.(((((((....((.((((((((((....((((((....)))))).....)))))))))).)).(((((((((((((((((((((((.......((((((((......(((((....))))).......))))))))......)))))))))))))))........((...))....))))))))....))))))).))))..((((........))))((((((..(.((((((((.((((..(((...(((.......)))...)))...((....)).......(((((..((....))...))))).((((((((....(....)....))).))).))....)))).))))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)A)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).)))..(((((......(((....)))..(((((((((.....((.(((((((.....(((........)).).....)))))...((((..(((.(......))))..)))).....))))...))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(....<.....(((.((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((..(((((((...((.....)).))))))....[[(((.((...(((...(((....)))........(((((......)))))....)))....))...(((((........)))))]]((((..(((((((...((((....)))...(.[.((((((...((((.(((((((((((((.((((...{{..)))).)(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....))).).))).)))).))).))).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((.(((((..)))))......)))))..)))))).))(...).......(((((((((.a.((.........))...(((((((....((((.....))))......))))))).].......((.((((((.(...((.....((((....)))).....)).)))))..)))).((((((.......))))))......((..))......)).))))))).)..))).)))))))..))))))....)).[..(((((......].)))))....(((((..((((.......(((((.((((((..(((((.((((((((..((.(((((()))))).))....((((.....((((..(((((....)))))...........]..(((((.....)))))..))))..))))......))))))))..))))).......((((((.((((((....))))))))...(((((((.(.((((((.......))))))...).((......))....)))))))....((((.(.(((.....))).)))))((((....))).))))).(((..(((((((..((((.]]]]]])))))))))))...).))..))))..)))))))...>[....((((((...((.......))...))))))...............(((...(((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..]....)))......(((((((....))).))))..>..)..))).)))))....(((((((..(((..(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...))))..)))....))))))).....(((((.((.(((....(.((.......(((....)))....))).......((((.....(((.(((((.......))))).)))....))))..............))))).)))))...(((((((..(.......)..))..(.(((((((((.(((....((((.(..(((.((..)..).)))..)))))...)))....))))..))))))..))))). Chaetomium thermophilum pre-60S State 7 - pre-5S rotation lacking Utp30/ITS2 - composite structure; 26S rRNA 8pvl C2 156 2.19 RF00002 URS000029C274_759272 37921038 0003735 0005840 759272 aaacuuucaacaacggaucucuugguucuggcaucgaugaagaacgcagcgaaaugcgauaaguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgcccgccgguauuccggcgggcaugccuguucgagcgucau .........................................<<<<<<<<<....>>>>.....<.<<<......>>..............>>>..>...>>>....<<.....>><<<<<<<<<....>>>>>>>>>................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))................... Chaetomium thermophilum pre-60S State 7 - pre-5S rotation lacking Utp30/ITS2 - composite structure; 5.8S rRNA 8q4f A 1512 3.1 RF00177,RF01959,RF02542,RF01960 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccggccagcagcccgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugccggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgauaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugcccuuacgaccagggcacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggauca .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<............>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>.>...<<<<<<.>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<.<<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<.......<<.<...>>>......>>>>..<.<<..<......<.<<<<<<<.........>>>>>>>.>........>..>>....>..<<<<<(((...<<<<<.......)))........>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>.>..........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<......>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<......>>..........<<<<<<<......<<.<<<<.....<<<......>>>......<<....>>..>>>>..>>..<.......<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<.......>>.>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>....>...>>>>>>>..>>.>>>>>>>>.....<<<<.........<<..<<...<<<....>>>...>>....>>.........>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>.....<<<<<<.........>>>>>>.......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .......((((..[.[[[..)))).((((.(((((...((((((((....(((.(((..(((..((.((..(((((.(..........).)).)))))..)))))......(((......(((((((..((...((((.((.(.((.....((.(((....))).))......)).).....(((....))).....(((((.)))))..)).))))..)).)))))))(((....(((..((((((.(.......).)))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).)))))...((...........(.....).........))..(..(..(...(....(((((((.........))))))).....)....)..).....)..((((([[[...((((.....(..]]])........)))))))))..)))))))))..........((([[...(.((((...(((.(((((.(.(((((((((.......((((((.....)))))).....)))))))..))).)))))..(((((((((...((((((((....(((((.(...(..........)......).)))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((..........)))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((......))..........((((.....(...((.(((.......((......))..................)))..)))..(...(...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...(.....(......)..)....))))))).....(((((.....)))))........)))).....).).)))...)).).)........))))..)).)))))))).(...(((...(..........((...(((....)))...))............)...)))......(....(.(................).)....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((.((((((((....(((((..(((...((....))..))).)))))...)))))))).)))..))).))))..).))...)..)..(((((((((....)))))))))}..... Structure of arbekacin bound Escherichia coli 70S ribosome; 16S rRNA 8q4f Z 76 3.1 RF00005 0030533 562 gcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((.........)))).(((((.......))))).....(((((.......)))))))))))..... Structure of arbekacin bound Escherichia coli 70S ribosome; tRNA-fMet 8q4f a 2732 3.1 RF02541 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcggggcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagcgucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcgcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacgguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccucccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauccuugucggguaaguuccgacugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugagaugcaguguacccgcggcaagacggaaagaccccguaaccuuuacuauagcuugacacugaacauauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgggaaacaggcgauaccgcccaagaguucauaucgacggcgguguuuggcacucggucggcucaucacauccuggggcugaaguaggucccaaggguauggcguucgccauuuaaagugguacgcgagcggguuuagaacgucgugagacagcggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu 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(.((((((......((((((((((.....(((..(((((((((((((......((((((.[...[[.))).....((((((...(((]]...].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(.((.(((((.((.(((...(((((......)))))[[(...).(((.....]])))...)))...)).))))).)).)...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.(.((..((((((....))))))..)).).[.(.(........).).((((((....(((((((((((((..((....((.....))....))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...).)))...(((.(((((....<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((..((((((.....(((...(((.(.((...((((..(.....)..)).))...)).).)))..)).).....))))))...)..)))))))).)...(((((((((.......)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{..()....)))..))))).))...........]]].)...))))))))))...)))))))((((((((..))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((...((((((...((.....)).))))))....[[(((.(((...(((...(((....)))...)))...)))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{..).))))))((..((((...((((((.(((((.((.....))))))).))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).)))..)).....((.....)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((...((.........))...(((((((.....(((....))).......))))))).}((((.((..(((((((..(((........(((((..((....))...)))))........))))))))..)))).(((((.........)))))........((.........(((((.......))))).)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((....]}.)))))..((((((((.(((.((......(.((.(((((..(((((.(((.(((((.((((....))))...(((.((((((.....)))))))))....))))).)))..)))))..(((.....[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....((.((((.((..]]]]..)))))).)).....)}......))))..).))).......((.(.((((((...((.......))...))))))...).)).......(.((.((((((..((.((((((......))))))...)).(((((....))))).....)))))..)...)).).....(..((((....))).))..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))..)))))...)))).)))))...(((....(.((.....}.......)).)....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))).). Structure of arbekacin bound Escherichia coli 70S ribosome; 23S rRNA 8q4f b 119 3.1 RF00001 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<......<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<........<<<<<<<...>>>>>>>........>>....>>>>>>>>> ((((((((((.....((((((.(....(((((((...(.....)...))))..)))...).)))).)).((.......((((((((...)))))))).......))...)))))))))) Structure of arbekacin bound Escherichia coli 70S ribosome; 5S rRNA 8q5i 1 3073 2.45 RF02543 URS0000C2FD9C_5476 0003735 0005840 5476 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.......................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........(((((...((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))).)..))))))))....))))..)))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((((((..(..((()))).((((((((((((((((.(((((((........((((((......((((((......)))))).......))))))......))))).))))))))))........(((....)))....))))))))....)))))))))))).[((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..((((....))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((((((((((....((.(((((((.....(((....(((..(.((((....(())..)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.((()))...)))))))))))))..........]]].)....))))))))))...)))))))(((((..((.........))..)))))....))))))(.((((((((.((......((((..(((....))).))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........(.((.((......)).))).....))....))...(((((........)))))]]((((..(((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((...)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(..(((.....((((....)))).....))))))))..)))))((((...........))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.)))))))...(((((.....((((..(((((......)))))...........>..((((...))))..))))..))))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).....((((((.(((.......((.(........((((....)))).....))).......((((((...(((((((..(((......)))..))))))).))))))................))).))))))..(((((((..(.......)..))..(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Structure of Candida albicans 80S ribosome in complex with cephaeline; 25S rRNA 8q5i 3 121 2.45 RF00001 URS00001B6144_5476 0003735 0005840 5476 gguugcggccauaucuagcagaaagcaccguuccccguucgaucaaccguaguuaagcugcuaagagcaauaccgaguaguguagugggagaccauacgcgaaacuauugugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Structure of Candida albicans 80S ribosome in complex with cephaeline; 5S 8q5i 4 158 2.45 RF00002 URS0000082EA4_5476 0003735 0005840 5476 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaauaugaauugcagauauucgugaaucaucgaaucuuugaacgcacauugcgcccucugguauuccggagggcaugccuguuugagcgucguuu .........................................<<<<<<.((.....>>>.....<.<<<<.....))............>>.>>..>...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............)).))..)...)))....((.....))(((((((((....)))))))))..................... Structure of Candida albicans 80S ribosome in complex with cephaeline; 5.8S rRNA 8q5i A 1558 2.45 RF01960,RF02542,RF01959,RF00177 URS000059AE3B_5476 0003735 0005840 5476 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguauacuuggauaaccgugguaauucuagagcuaauacaugcuuaaaaucccgacuguuuggaagggauguauuuauuagagaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaaucccgacacggggagguagugacaauaaauaacgauacagguuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaaaagcguauauuaaaguuguugcaguuaaaaagcucguaguugaaccuugggcuuggcugcagccgagccuuuuuuacuuugaaaaaauuagaguguucaaagcaggccuuugcucgaauauauuagcauggaauaauagaauaggacguuauaucguaaugauuaauagggacggucggggguaucaguauucaguugucagaggugaaauucuuggauuuacugaagacuaacuacugcgaaagcauuuaccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgguuguuguucugacgcaaucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacugagagcugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauagugccacuucuuagagggacuaucgauuucaagucgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgaguauaagccuuggccgagaggucugggaaaucuugugaaacuccgucgugcuggggauagagcauuguaauuguugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuacuaccgauugaauggcuuagugaggccuccggauuggcgagaagcuggucaaacuuggucauuuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucau ...<<<<<.[.((((>>>>><<<<.<<<<<<...<.<...<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<..<<..<<....<<<.........<<.....<..<<.......>>..>......>>........<<<<<..<<....>>..>>>>><...<<<<<<...........>>>>>>.....>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>....>.>.....<<<<...<..>...>>>>......<<..<...........>..>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>>>>>.........<<<((.....<.<<...<<<.<<....<<<<<<<<<<..>>>>>>>>>>...<<<<<.<<.......<<...<.......>..<<<....>>>....>>......>>.>>..>>>.........<<<..<..>>>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<..<<..>>.>>>>>>>>..>>>...<<..))>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<.<......<<........>>..........<<<<<.<....<<<........>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<.>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>..>>>>.>>>.....<<<<<<<......<<......<<<.<<<<....>>>>.>>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<..<...<<<.>>>...>..>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>....... ....(((..[.[[[..))).((((.((((((...(.(...((.....(((.(((..((....((....((..........))...))[))......(((.......(((..((..((....(((.........((.....(..(((.....)))..)......))........(((((..((....))..)))))(.(.(((((...(......)..))))).)...).(..(((..((((..).))).))).)...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)....).).....((((..(.....).))))......(.(.(...........))..).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..[......((([[...(.(.((...(((.((....((((((((((()))))))))))...(((((.((.......((..((.......)).(((....)))....))......)).))..))).........(((..(())))).....))....((..((..(...((((...((.((((((.....((........))........)))))).))........((....))...))))..)..))...))...)))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..((((((((..(....).))))))))..)))...((..]]))...))...].))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((........)))...((.(((...(..((((.....(((.(((((....)))..(.((......)))...)).)))....(((((.((...(((..((((.))))..)))..))..(.((((((.....))))))....)..))))).....)).))......).))))).....).)))))...)).)))).))).(...(((((((......((......(((.((((....)))).)))....)).......)))))))......(....((((((..........))))))....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..((((..(...(((.)))...)..))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}...... Structure of Candida albicans 80S ribosome in complex with cephaeline; 18S ribosomal RNA 8q7n 5 115 3.1 RF00020 URS000075BAAE_9606 38383864 0000244,0000353 0005682,0046540 9606 acucugguuucucuucagaucgcauaaaucuuucgccuuuuacuaaagauuuccguggagaggaacaacucugagucuuaacccaauuuuuugaggccuugcuuuggcaaggcua .<<<...<<<<<<<<<<........<<<<<<<<...........>>>>>>>>...>>>>>>>>>>.......>>>...................<<<<<<<<....>>>>>>>>. .(((...((((((((((...((...((((((((.(.......).)))))))).)))))))))))).......)))...................((((((((....)))))))). cryo-EM structure of the human spliceosomal B complex protomer (tri-snRNP core region); U5 snRNA 8q7n 6 78 3.1 RF00026 URS000035C796_9606 38383864 0030621 0000244,0000353 0005688,0046540 9606 gugcucgcuucggcagcacauauacuaaaauuggaacgauacagagaagauuagcauggccccugcgcaaggaugaca <<<<<.<<....>>>>>>>........................................................... (((((.((....)))))))........................................................... cryo-EM structure of the human spliceosomal B complex protomer (tri-snRNP core region); U6 snRNA 8q7n Z 31 3.1 38383864 9606 ccuccgaacgguaagagccuagcauguagaa ............................... ............................... cryo-EM structure of the human spliceosomal B complex protomer (tri-snRNP core region); MINX pre-mRNA 8q7n 4 76 3.1 RF00015 URS0000200C70_9606 38383864 0017070 0000244,0000353 0005687,0046540 9606 agcuuugcgcaguggcaguaucguagccaaugagguuuauccgaggcgcgauuauugcuaauacuuuucccaauac ...................<<<<<.<<<.....<<.....>>..>>>>>>>>........................ ...................(((((.(((.....((.....))..))))))))........................ cryo-EM structure of the human spliceosomal B complex protomer (tri-snRNP core region); U4 snRNA 8q7z B5 3562 2.5 RF02543 0003735 0005840 9031 cgcgaccucaggucagacguggcgacccgcugaauuuaagcauauuagucagcggaggaaaagaaacuaacgaggauucccucaguaacggcgagugaagagggaagagcccagcgccgaauccccgccccgcgguggggcgcgggagguguggcguacggaagcccccauccccggcgccgcucucggggggcccaaguccuucugaucgaggcccagcccgcggacggugugaggccgguagcggcccccggcgcgccgggcccggggcuucucggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagccaacaaguaccguaagggaaaguugaaaagaacuuugaagngngaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcagucggcccggaggauucaacccggcgggccaaggucggccggcgcgggcgcggauccccgccuccgccgggcgggccggggaccgccgcccggccggcguccggcccccgucgggcgcauuuccuccgcggcggugcgccgcgaccggcuccgggacggcugggaagggcugccggcgggcagguggcccgggccggguguuauagccgccgggcccggaucgucgccgaaucccggggccgagggagaggaccgccgccgcgcccucccucgggggacgggcccgccggcccccggcgccgcuguccggggcggacugcgcucagugcgccccgaccggcggcgccgccgggccgggcucgggccacgccagggcgcccgggguccgcggcgacgucggcuacccacccgacccnucuugnaacncggaccaaggagunuagcacgcgcgcgagucggcggcucgcgcgaaagcccgcggcgcaaugaaggugagggccggcgcgcgccggcugaggugggaucccggggcggcaggccggaaggccccgggcgcaccaccggcccgucucgcccgccucgccggggagguggagcaugagcgcgcgugcuaggacccnanagauggugancuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgacccggguauagnggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucggggcggcggugcaguuuuacccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuucaauggguaagacgcccggcucgcuggcguggagccgggccguggaaugcgagcgcucagugggccacuuuugguaagcngaacuggcgnugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagagcccagaaaagguguugguugaucuagacagcgccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcggugcggagccgcgggggcuacgccgcgacgaguaggagggccgcugcggugcgccuggaagccuggggcgcgggcccggguggagccgccgcaggugcagaunuuggugguagunncaacuauucaaacgagagcuuugaaggccgaaguggagcaggguuccaugugaacagnanuugaacaugggucagucgguccuaagcgauaggcgagcgccguuccgaagggacgggcgauggccuccguugcccucagccgaucgaaagggagucggguucagauccccgaauccggagcggcggagacgggcgccgcgaggcgcccagugcgguaacgcaagcgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggccgggcgcccuggaacggguucgccccgagagaggggcccgcgccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccgugaaaauccgggggagaggguguaaaucucgcgccgggccguacccnuauccgcagcaggucuncaaggugaacngccucuggcauguuggaccaanguagguaagggaagucggcaagcnggauccguaacuucnggauaaggauuggcucuaagggcugguagcagccggcuuagaacuggugcggaccaggngaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugccnagugcucugaaugucanagugangaaauucaaugaagcgcggnuaaacggcgggaguaacuaugacucucuuaagguagcnaanugccucnucaucuaauuagugangcgcaugaanggaugancgagnuucccacugunccuaucuacuauccagcgaaaccacngncaagggaacgggcuuggnggaaucagcggngaaagaagacccuguugagcuugacncuagucuggcgcugugaagagacaugagagguguagaauaagugggaggccccggccgccggugaaauaccacuacucugaucguuuuuucacuuacccggugaggcgggggggcgagccccgaggggcucucgcuucuggcgccaagcgcccggcgcgcgccgggcgcgacccgcuccggggacagcgucagguggggaguuugacugnggcgguacaccugucaaagcguancgcaggnnuccuaaggcgagcucagggaggccagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucagnacgaauacagaccgugaaagcggggccucacgauccuucugacuuuuuggguuuuaagcaggangugucagaaaaguuaccacagngauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuungaugucggnucuuccuaucauugugaagcagaauucaccaagcguungaunnuucacccacuaauagggaacgugngcugggnuuagancgucgugagacagguuaguuuuacccuacugaugnuguguuguugcgcuaguanuccugcucaguacgagaggaaccgcagnuncanacauuugguguaunugcuuggcugaggagccacuggagcgaggcuaccaucugugggauuaugacugaacgccucuaagucagaauccccccuaaacguagcgauaccgcagcgccgaggcgccucggugggcucgcgauagccggccgccgccccccucgggcgggcggucggugcggagcgccgcucguggucgggaccggagcgcggacagauguggcgccgccucucccccgccgcguaccgcauguucguggggaacccggugcuaaaucauucguagacgaccugauucugggucgggguuucguacguagcagagcagcucgcugcgaucuauugagagucagcccucgacacaagcuuuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..[[[..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>>..<<<<<<<<<....<<<<<<<<.<<<....<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>>>>>>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<.<....<.<<<<<<<<<<.....<<<<<<<<<....<<<<<<<<<<...<<..<<<<.<<<<<<.<<<..<..>..>>>.>>>>>>>>>>..>>...>>>>...>>>>>>>>>>>>>>>......>>>>>>>.>>>.>...<<<<<<<<<<<<<<<<<<<<<<<...<<.<<<<..<<<<<<<.......<<<<<<.>>>>>>.......>>>>>>>>>>>......>>>>>>..>>>>>>>>>>>..................<<<<<<<<<......>>><<<<<<..<<<<<<<.<<<<<<<<<<<..<<<<<<<.<<<<....>>>>.>>>>>>>..>>>>>>>>>>>..>>>>>>>.....>>>>.>>...>>>>>>.....>>>.>>>>>....>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>...>>>...<<....>>...<<<<<<<....>>>>>>>..<<<<<...<<<<<<<<.............>>>>>>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<...........<<<.<<<<<<<<<...<<<....<<<..<.<<<..<<<<<<.........>>>>>>>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.<......>>>>>>>>>>.....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<..>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<......................>>>>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<<.<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<.....<<<....>>>..........<<.<<<<<<<<<...>>>>>>>>>>>.......>....>>>..<<<<<........>>>>>))<<<<....<<<<<...<<<<<<<....>>>>>>>...<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..{{{..>>>>>>....<<<<<<<<<<.<<<<.....<<<.....>>>.....>>>>>>>>>.>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>.>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<...............<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<....>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<...<.<<<<....>>>>.>...>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<<.<<<<<<<<<<...<<<<..........<<<<<..<<<<..>>>>............>>>>>.>>>>....>>>>>>>>>>...<<<<<.....<<<<..<<.<<<<<<<..>>>>>>>>>..............<<<<<<<<<<..>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>><<<<....>>>>>>)))]......((((((..(((..>>>>>>.)))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]].....<<<<<<<<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<...<<<.<<<<<<<}}}.>>>>>..>>.>>>..>>>>...>>>>.<<<<...<<<<<...........>>>>>...>>>>..>>>...>>>>>>>>.....<<<<<<<.<<..<<<<....<<<........<<<<<<<<<<..<<<....>>>..>>>>>>>>>>.......>>>...<<<<<<.<<<....<<<.<<<<............>>>>>>>..>>>.>>>>>>..............>>>>..>>>>>>>>><<<...<.............>....<<.<<<<<<<.<<<....<<<<.<..<<<<<..>>>>>..>>>>>...>>>....>>>>.>>>.>>....>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..(((((((((((.....)))))).))))....))))....(((((((((....((((((((.((.....((((((((..({((((......)))))....[[(...).(((....}]])))...).))))))).))))))))))...)))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...(.((((((((((.....(((((((((....(((((((((....((..((((.((((((.(((..(..)..))).))))))))))..))....)))...)))))))))))))))......))))))).))).)...(((((((((((((((((((((((...((.((((..(((((((.......((((((.)))))).......)))))))))))......))))))..)))))))))))..................((((((((((....))))((((((..(((((((.(((((((((((..(((((((.((((....)))).)))))))..)))))))))))..))))))).....)))).))...)))))).....))).)))))...)))))...)))))))).[((((........))))((((((....(((((((((((((..(((...((((........))))...)))...((....))...(((((((....)))))))..(((((...((((((((.............))))))))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((...........(((.((((((((.....((.....((..(.(((...((((..(.....)..)))).))).)..))...))......))))))...(((((((((.(......)))))))))).....))))))))))))..))..((((..(.((.....)).)..))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.....{.(())...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((.........(...)........)))))))))....)))))).(.((((((((.((......(((((.(((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((..(((((((...((.....)).))))))....[[(((.((...(.....(((....)))..........((.((((((.((...)).)))))))).......)....))...(((((........)))))]]((((....(((((...(((((((....)))))))..((((....)))...(...((((((...(((((((((((((((((((((((..{{{..))))))....((((((((((.((((.....(((.....))).....))))))))).))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).))).))).....((......)).)))).((((.....))))..)))....((((.....((((.((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((....)))))..)))))).))(...).......(((((((((.].(...........)...(((((((....((((.....))))......))))))).}.(.(.(((..((((((.(...(......((((....))))......).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....).)....)).))))))).)..))).)).))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.(((((...(((((.(((((((((.((((((((((...((((.......[...((((..((((..))))..........].))))..))))....))))))))))...(((((.....((((..(..(((((((..))))))).)..............((((((((((..))))))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(..((....((....{..))....)).)(((....))).))]]].......((((((...((..]]]]]].)).))))))....)}.....)))..)))))).......(....(.((((.(...((.......))...).))))...)....)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).)......((((((....))).)))...>.))..))).))))).....(.((.(((..(((..(.(((((......(....).....))))).)(((.....((((....((.(((((((}}}.)))))..)).))...))))....))).((((...((((.....}.......))))...))))..)))...))).)).).....(((((((.((..((((.(..(((........((((((((((..(((....)))..)))))))))).......)))...((((((.(((...((((.((((.(.......)..))))))).)))).))))))...........)..))))..)))))))))(((.(....(.......).......((.(((((((.(((....((((.(..(((((..)))))..)))))...)))....)))).))).)).)..))).. Structure of the G. gallus 80S non-rotated ribosome; 28S rRNA 8q7z B8 157 2.5 RF00002,RF02540 0003735 0005840 9031 caacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauuncaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugccugagcgucgcuu .........................................<<<<<<<<<....>>>>.....<.<<<......>>.............>>>..>...>>>....<<....>><<<<<<<<<.....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))(((((((((.....)))))))))..................... Structure of the G. gallus 80S non-rotated ribosome; 5.8S rRNA 8q7z B7 119 2.5 RF00001 0003735 0005840 9031 gccuacggccaucccacccugguaacgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccuccugggaauaccgggugcuguaggcu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<<.<<....>>>>>.>>....>>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.(((.((....))))).)).....))))))))))))))). Structure of the G. gallus 80S non-rotated ribosome; 5S rRNA 8q7z A2 1676 2.5 RF01960,RF02542,RF01959,RF00177 0003735 0005840 9031 uaccugguugauccugccaguagcaunugcuugucucaaagauuaagccaugcaugucuaaguacacacgggcgguacagugaaacugcgaauggcucnuuaaaucaguuauggunccuunggucgcuccuacuuggauaacugugguanuucuagngcuaananaugccgacgagcgccgaccuccggggacgcgugcauuuaucaguggugacucuagauaaccucgagccgaucgcacgcccccguggcggcgacgacccauucgaaugucngcccuaucaacuuucgaugguacugucugugccuaccauggugaccacggguaacggggaaucaggguucgaunccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcnaauuacccacucccgacccgggganguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggnuccauuggagngcaagucuggugccagcagccgcgguaauuccagcuccaauancguauauuaaaguugcugcaguunaaaagcucguaguungaucuugggauucccaguuuacuuugaaaaaauuagaguguucaaagcaggcuggccgccggaauacuccagcuaggaauaauggaauaggacuccgguucuauuucggaaacggggccaugauuaagagggacggccgggggcauucguauugugccgcuagaggugaaauucuuggaccggcgcaagacgaacuaaagcgaaagcauuugccaagaauguuuucauuaaucaagancgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgacucgcgauccggcggcguuauucccaugacccgccgggcagcucccgggaaacccaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacncaacacgggaaaccucacccggcccggacacggacaggauugacagauugagagcucuuucucgauuccguggguggngnugcauggcnguucuuaguugguggagcgauuugucugguuaauuccgauaacgancgagacucuggcaugcuaacuaguuacgcgacccccgagcggucggcguccaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacangucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcuugugucuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcucgcguugauuaagucccugcccuuuguacacaccgnccgucgcuacuaccgauuggaugguuuagugagguccucggaucggccccggcggggucggccacggcccugccggagcgucgagaagacggucgaacuugacuaucuagaggaaguaaaagucguancaagguuucnguaggugnnccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<<<..<<....<<<<<.........<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<..>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<<.....>>>>>>>>.>>.>>>...>>>>>.>>>.<<<....<<<....<<<<<<...........>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....<<<<<<<<<.<<<....>>>..>>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<...<.<<....>>>..<<<<<<.<.......<<...<.......>..<<<.....>>>....>>......>.>>>..>>>........<.<<<<<.<<<<.....>>>>.>>>>>.>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<..<<..<<<<<<<<.<<<<<....>>>>>>>>>>>>>..>>....<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<.......>>>>.>>>>..>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<.<<<<<<..<<<<....>>>>..>>>>>>...>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))(((..(((((...(.((..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(((..((....(((.....(.[...((.....((.(((.....))).))......)).......).((((...((....))...))))((..(((((...(......)..)))))......)).(]((((.((((.....)))))))))...)))...))))).))).(((....(((....((((((...........)))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).).....(((((((((.(((....)))..)))))).)))....(.((..(...........)..))......)..((((([[....(.((((.....((..]])).......))))))))))..)))))..)))..[......(.([[...(.(.((...(.(..(.....((....))...((((((.(........(..((.......)).(((.....)))....).......).)))..)))........(.((((..(((.......)))..)))).)....).....((..(...(...((((..((..((((((((...((........))......))))))))..)).......((....))...))))..)...)...))...).)...)).)....((((((....(...((((.........))))...).))))))......{...(((.((..((..((((((((.(((((....)))))))))))))..))....((..]]))...))...].))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(.(((........((.(((........))).))......))).)...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((...(...((((..(((((((((((((....).)))).))))..))))..))))..).....(((((.....)))))........)))....))).))).....).))))).....).)))))...)).)))).))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..((((.((...(((((((((((..(..((....))..)..))))).).)))))...)).))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}........ Structure of the G. gallus 80S non-rotated ribosome; 18S rRNA 8q7z V 76 2.5 RF00005 0030533 9031 gccgaaauagcucaguugggagagcgggagacugaagauccaaaggucccugguucgaucccgggucccggcacca <<<<..<..<<<<........>>>>....<<.......>>........<<<<<.......>>>>>>..>>>>.... ((((..(..((((.....[..))))....((.......))........(((((..]....))))))..)))).... Structure of the G. gallus 80S non-rotated ribosome; Phe tRNA 8q87 B5 3638 2.4 RF02543 0003735 0005840 9031 cgcgaccucaggucagacguggcgacccgcugaauuuaagcauauuagucagcggaggaaaagaaacuaacgaggauucccucaguaacggcgagugaagagggaagagcccagcgccgaauccccgccccgcgguggggcgcgggagguguggcguacggaagcccccauccccggcgccgcucucggggggcccaaguccuucugaucgaggcccagcccgcggacggugugaggccgguagcggcccccggcgcgccgggcccggggcuucucggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagccaacaaguaccguaagggaaaguugaaaagaacuuugaagngngaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcagucggcccggaggauucaacccggcgggccaaggucggccggcgcgggcgccggauccccgccuccgccgggcgggccggggaccgccgcccggccggcguccggcccccgucgggcgcauuuccuccgcggcggugcgccgcgaccggcuccgggacggcugggaagggcugccggcgggcagguggcccggcgccgcgcgagcggccgccggguguuauagccgccgggcccggaucgucgccgaaucccggggccgagggagaggaccgccgccgcgcccucccccgggggacgggcccgccggcccccggcgccgcuguccgggggcggacugcgcucagugcgccccgaccggcggcgccgccgggccgggcucgggccacgccagggcgcccgggguccgcggcgacgucggcuacccacccgacccnucuugnaacncggaccaaggagunuagcacgcgcgcgagucggcggcucgcgcgaaagcccgcggcgcaaugaaggugagggccggcgcgcgccggcugaggugggaucccggggcggcaggccggaaggccccgggcgcaccaccggcccgucucgcccgccucgccggggagguggagcaugagcgcgcgugcuaggacccnanagauggugancuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgacccggguauagnggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucggggcggcggugcaguuuuacccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuucaauggguaagacgcccggcucgcuggcguggagccgggccguggaaugcgagcgcucagugggccacuuuugguaagcngaacuggcgnugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagagcccagaaaagguguugguugaucuagacagcaggacgguggccauggaagucggaacccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcggugcggagccgcgggggcuacgccgcgacgaguaggagggccgcugcggugcgccuggaagccuggggcgcgggcccggguggagccgccgcaggugcagaunuuggugguagunncaacuauucaaacgagagcuuugaaggccgaaguggagcaggguuccaugugaacagnanuugaacaugggucagucgguccuaagcgauaggcgagcgccguuccgaagggacgggcgauggccuccguugcccucagccgaucgaaagggagucggguucagauccccgaauccggagcggcggagacgggcgccgcgaggcgcccagugcgguaacgcaagcgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggccgggcgcccuggaacggguucgccccgagagaggggcccgcgccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccgugaaaauccgggggagaggguguaaaucucgcgccgggccguacccnuauccgcagcaggucuncaaggugaacngccucuggcauguuggaccaanguagguaagggaagucggcaagcnggauccguaacuucnggauaaggauuggcucuaagggcugguagcagccggcuuagaacuggugcggaccaggngaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugccnagugcucugaaugucanagugangaaauucaaugaagcgcggnuaaacggcgggaguaacuaugacucucuuaagguagcnaanugccucnucaucuaauuagugangcgcaugaanggaugancgagnuucccacugunccuaucuacuauccagcgaaaccacngncaagggaacgggcuuggnggaaucagcggngaaagaagacccuguugagcuugacncuagucuggcgcugugaagagacaugagagguguagaauaagugggaggccccggccgccggugaaauaccacuacucugaucguuuuuucacuuacccggugaggcgggggggcgagccccgaggggcucucgcuucuggcgccaagcgcccggcgcgcgccgggcgcgacccgcuccggggacagcgucagguggggaguuugacugnggcgguacaccugucaaagcguancgcaggnnuccuaaggcgagcucagggaggccagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucagnacgaauacagaccgugaaagcggggccucacgauccuucugacuuuuuggguuuuaagcaggangugucagaaaaguuaccacagngauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuungaugucggnucuuccuaucauugugaagcagaauucaccaagcguungaunnuucacccacuaauagggaacgugngcugggnuuagancgucgugagacagguuaguuuuacccuacugaugnuguguuguugcgcuaguaauccugcucaguacgagaggaaccgcagnuncanacauuugguguaunugcuuggcugaggagccacuggagcgaggcuaccaucugugggauuaugacugaacgccucuaagucagaauccccccuaaacguagcgauaccgcagcgccgaggcgccucggugggcucgcgauagccggccgccgccccccucgggcgggcggucggugcggagcgccgcucguggucgggaccggagcgcggacagauguggcgccgccucucccccgccgcguaccgcauguucguggggaacccggugcuaaaucauucguagacgaccugauucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugagagucagcccucgacacaagcuuuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..[[[..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>>..<<<<<<<<<....<<<<<<<<.<<.....<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>.>>>>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<......>>>..................................<<<<<<<<..<<<.<......<<<<<<<<<<.....<<<<<<<<<....<<<<<<<<<<<..<<....<<<.<<<<<<.<<<........>>>.>>>>>>>>>...>>..>>>>>...>>>>>>>>>>>>>>>......>>>>>>>.>>>.....<<<<<<<<<<<<<<<<<<<<<<<...<<.<<<<..<<<<<<<.......<<<<<<<<.............>>>>>>>>.......>>>>>>>>>>>......>>>>>>..>>>>>>>>>>>..................<<<<<<<<<<<..>>>>><<<<<<..<<<<<<<.<<<<<<<<<<<....<<<<<<.<<<<....>>>>.>>>>>>...>>>>>>>>>>>..>>>>>>>.....>>>>.>>...>>>>>>.....>>>.>>>>>....>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>...>>>...<<....>>...<<<<<<<....>>>>>>>..<<<<<...<<<<<<<<.............>>>>>>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<...........<<<.<<<<<<<<<...<<<....<<<..<.<<<..<<<<<<.........>>>>>>>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.<......>>>>>>>>>>.....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<......................>>>>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<<.<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<..<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<.....<<<....>>>..........<<.<<<<<<<<<...>>>>>>>>>>>.......>....>>>..<<<<<........>>>>>))<<<<....<<<<<...<<<<<<<....>>>>>>>...<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..{{{..>>>>>>....<<<<<<<<<<.<<<<.....<<<.....>>>.....>>>>>>>>>.>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>.>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<.<<<<<<<<<<<....>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<...<.<<<<....>>>>.>...>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<<.<<<<<<<<<<<<.<<<<..........<<<<<..<<<<..>>>>............>>>>>.>>>>.>>.>>>>>>>>>>...<<<<<.....<<<<..<<.<<<<<<....>>>>>>>>..............<<<<<<<<<<..>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>><<<<....>>>>>>)))]......((((((.[.((..>>>>>>.))]))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]].....<<<<<<<<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<}}}.>>>>>..>>.>>...>>>>...>>>>.<<<<...<<<<<...........>>>>>...>>>>..>>>...>>>>>>>>.....<<<<<<<.<<..<<<<....<<<........<<<<<<<<<<..<<<....>>>..>>>>>>>>>>.......>>>...<<<<<<.<<<....<<<.<<<<............>>>>>>>..>>>.>>>>>>..............>>>>..>>>>>>>>><<<...<.............>....<<.<<<<<<<.<<<....<<<<.<..<<<<<......>>>>>..>>>>>...>>>....>>>>.>>>.>>....>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..(((((((((((.....)))))).))))....))))....(((((((((....(((((.((.((.....((((((((..({((((......)))))....[[(...).(((....}]])))...).))))))).)))).)))))...)))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...(.((((((((((.....(((((((((....(((((((((((..((..(.(((.((((((.(((........))).))))))))))..))..)))))...)))))))))))))))......))))))).))).)...(((((((((((((((((((((((...((.((((..(((((((.......((((((((.............)))))))).......)))))))))))......))))))..)))))))))))..................(((((((((((())))))((((((..(((((((.(((((((((((....((((((.((((....)))).))))))...)))))))))))..))))))).....)))).))...)))))).....))).)))))...)))))...)))))))).[((((........))))((((((....(((((((((((((..(((...(((..........)))...)))...((....))...(((((((....)))))))..(((((...((((((((.............))))))))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((...........(((.((((((((.....((.....((..(.(((...((((..(.....)..)))).))).)..))...))......))))))...(((((((((.(......)))))))))).....))))))))))))..))..((((..(.((.....)).)..))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.....{.(((((.((([..((.........))...))).....(]..((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((.........(...)........)))))))))....)))))).(.((((((((.((......(((((.(((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((..(((((((...((.....)).))))))....[[(((.((...(.....(((....)))...(.)....((.((((((.(({..)).)))))))).......)....))...(((((........)))))]]((((...}(((((...(((((((....)))))))..((((....)))...(...((((((...(((((((((((((((((((((((..{{{..))))))....((((((((((.((((.....(((.....))).....))))))))).))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).))).))).....((......)).)))).((((.....))))..)))....((((.....((((.((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((....)))))..)))))).))............(((((((((.].(...........)...(((((((....((((.....))))......))))))).}.(.(.(((..((((((.(..((......((((....))))......)))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....).)....)).))))))).)..))).)).))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.(((((...(((((.(((((((((.((((((((((((.((((.......[..(((((..((((..))))..........].))))).)))).)).))))))))))...(((((.....((((..(..(((((((..))))))).)..............((((((((((..))))))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(..((....((....{..))....)).)(((....))).))]]].......((((((...((..]]]]]].)).))))))....)}.....)))..)))))).......(....(.((((.(...((.......))...).))))...)....)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).)......((((((....))).)))...>.))..))).))))).....(.((.(((..(((..(.(((((......(....).....))))).)(((.....((((....((.(((((((}}}.)))))..)).))...))))....))).((((...((((.....}.......))))...))))..)))...))).)).).....(((((((.((..((((.(..(((........((((((((((..(((....)))..)))))))))).......)))...((((((.(((...((((.((((.(.......)..))))))).)))).))))))...........)..))))..)))))))))(((.(....(.......).......((.(((((((.(((....((((.(..(((((......)))))..)))))...)))....)))).))).)).)..))).. Structure of the G. gallus 80S rotated ribosome in complex with eEF2 and SERBP1; 28S rRNA 8q87 B8 157 2.4 RF00002,RF02540 0003735 0005840 9031 caacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauuncaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugccugagcgucgcuu .........................................<<<<<<<<<....>>>>.....<.<<<......>>.............>>>..>...>>>....<<....>><<<<<<<<<.....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))(((((((((.....)))))))))..................... Structure of the G. gallus 80S rotated ribosome in complex with eEF2 and SERBP1; 5.8S rRNA 8q87 B7 119 2.4 RF00001 0003735 0005840 9031 gccuacggccaucccacccugguaacgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccuccugggaauaccgggugcuguaggcu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<<.<<....>>>>>.>>....>>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.(((.((....))))).)).....))))))))))))))). Structure of the G. gallus 80S rotated ribosome in complex with eEF2 and SERBP1; 5S rRNA 8q87 A2 1697 2.4 RF01960,RF02542,RF01959,RF00177 0003735 0005840 9031 uaccugguugauccugccaguagcaunugcuugucucaaagauuaagccaugcaugucuaaguacacacgggcgguacagugaaacugcgaauggcucnuuaaaucaguuauggunccuunggucgcuccuacuuggauaacugugguaauucuagngcuaanacaugccgacgagcgccgaccuccggggacgcgugcauuuaucaguggugacucuagauaaccucgagccgaucgcacgcccccguggcggcgacgacccauucgaaugucngcccuaucaacuuucgaugguacugucugugccuaccauggugaccacggguaacggggaaucaggguucgaunccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcnaauuacccacucccgacccgggganguagugangaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggnuccauuggagngcaagucuggugccagcagccgcgguaauuccagcuccaauancguauauuaaaguugcugcaguunaaaagcucguaguungaucuugggaucgagcugccgccugucccaggucucucggcgccccggggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggcuggccgccggaauacuccagcuaggaauaauggaauaggacuccgguucuauuuuguugguuuucggaaacggggccaugauuaagagggacggccgggggcauucguauugugccgcuagaggugaaauucuuggaccggcgcaagacgaacuaaagcgaaagcauuugccaagaauguuuucauuaaucaagancgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgacucgcgauccggcggcguuauucccaugacccgccgggcagcucccgggaaacccaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacncaacacgggaaaccucacccggcccggacacggacaggauugacagauugagagcucuuucucgauuccguggguggngnugcauggcnguucuuaguugguggagcgauuugucugguuaauuccgauaacgancgagacucuggcaugcuaacuaguuacgcgacccccgagcggucggcguccaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacangucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcuugugucuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcucgcguugauuaagucccugcccuuuguacacaccgnccgucgcuacuaccgauuggaugguuuagugagguccucggaucggccgucgagaagacggucgaacuugacuaucuagaggaaguaaaagucguancaagguuucnguaggugnnccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<<<..<<....<<<<<.........<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<..>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<<.....>>>>>>>>.>>.>>>...>>>>>.>>>.<<<....<<<....<<<<<<...........>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....<<<<<<<<<.<<<....>>>..>>>>>>.>>>......<<..<...........>..>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<.....<<..<<.<<....>>.>>..>>...<...<<<..<<<<<>>>>>.>>>.>...<<<<<<.<.......<<...<.......>..<<<.....>>>....>>......>.>>>..>>>........<.<<<<<.<<<<...............>>>>.>>>>>.>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<..<<..<<<<<<<<.<<<<<....>>>>>>>>>>>>>..>>....<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<.......<<........>>..........<<<<<.<....<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<.......>>>>.>>>>..>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.....>.>>>>>....>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<...>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))(((..(((((...(.((..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(((..((....(((.....(.[...((.....((.(((.....))).))......)).......).((((...((....))...))))((..(((((...(......)..)))))......)).(]((((.((((.....)))))))))...)))...))))).))).(((....(((....((((((...........)))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).).....(((((((((.(((....)))..)))))).)))....(.((..(...........)..))......)..((((([[....(.((((.....((..]])).......))))))))))..)))))..)))..[......(.([[...(.(.((...(.(..(.....((..((.((.().)).))..))..(.(..(((..((((())))).))).))..((.(((.(........(..((.......)).(((.....)))....).......).)))...))........(.((((....((...............))....)))).)....).....((..(...(...((((..((..((((((((...((........))......))))))))..)).......((....))...))))..)...)...))...).)...)).)....((((((....(...((((.........))))...).))))))......{...(((.((..((..((((((((.(((((....)))))))))))))..))....((..]]))...))...].))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((........((.(((........))).))......)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((...(...((((..(((((((((((((....).)))).))))..))))..))))..).....(((((.....)))))........)))....))).))).....).))))).....).)))))...)).)))).))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..((((.((...(((.(.).)))...)).))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}........ Structure of the G. gallus 80S rotated ribosome in complex with eEF2 and SERBP1; 18S rRNA 8q87 V 76 2.4 RF00005 0030533 9031 gccgaaauagcucaguugggagagcgggagacugaagauccaaaggucccugguucgaucccgggucccggcacca <<<<..<..<<<<........>>>>....<<.......>>........<<<<<.......>>>>>>..>>>>.... ((((..(..((((.....[..))))....((.......))........((.((..]....)).)))..)))).... Structure of the G. gallus 80S rotated ribosome in complex with eEF2 and SERBP1; Phe tRNA 8qbk C 61 2.99 38788717 469008 ugcgcacccuuagcgagaggccucuggauguugcggcauccugcauugaaucugaguuacu ...............<<<<..>>>><<<<<<<..>>>>>>>.................... ..............(((((()))))(((((..()..)))))..)................. Retron-Eco1 filament with ADP-ribosylated Effector (local map with 1 segment); Retron-Eco1-msr 8qbk D 14 2.99 38788717 469008 cguaagggugcgca .............. .............. Retron-Eco1 filament with ADP-ribosylated Effector (local map with 1 segment); Retron-Eco1-A2 8qbk M 61 2.99 38788717 469008 ugcgcacccuuagcgagaggccucuggauguugcggcauccugcauugaaucugaguuacu ...............<<<<..>>>><<<<<<<..>>>>>>>.................... ..............(((((()))))(((((..()..)))))..)................. Retron-Eco1 filament with ADP-ribosylated Effector (local map with 1 segment); Retron-Eco1-msr 8qbk N 14 2.99 38788717 469008 cguaagggugcgca .............. .............. Retron-Eco1 filament with ADP-ribosylated Effector (local map with 1 segment); Retron-Eco1-A2 8qbk R 61 2.99 38788717 469008 ugcgcacccuuagcgagaggccucuggauguugcggcauccugcauugaaucugaguuacu ...............<<<<..>>>><<<<<<<..>>>>>>>.................... ..............(((((()))))(((((..()..)))))..)................. Retron-Eco1 filament with ADP-ribosylated Effector (local map with 1 segment); Retron-Eco1-msr 8qbk S 14 2.99 38788717 469008 cguaagggugcgca .............. .............. Retron-Eco1 filament with ADP-ribosylated Effector (local map with 1 segment); Retron-Eco1-A2 8qbk W 61 2.99 38788717 469008 ugcgcacccuuagcgagaggccucuggauguugcggcauccugcauugaaucugaguuacu ...............<<<<..>>>><<<<<<<..>>>>>>>.................... ..............(((((()))))(((((..()..)))))..)................. Retron-Eco1 filament with ADP-ribosylated Effector (local map with 1 segment); Retron-Eco1-msr 8qbk X 14 2.99 38788717 469008 cguaagggugcgca .............. .............. Retron-Eco1 filament with ADP-ribosylated Effector (local map with 1 segment); Retron-Eco1-A2 8qbl C 61 2.66 38788717 469008 ugcgcacccuuagcgagaggccucuggauguugcggcauccugcauugaaucugaguuacu ...............<<<<..>>>><<<<<<<..>>>>>>>.................... ..............(((((()))))(((((..()..)))))..)................. Retron-Eco1 filament with inactive effector (E106A, 2 segments); Retron-Eco1-msr 8qbl D 14 2.66 38788717 469008 cguaagggugcgca .............. .............. Retron-Eco1 filament with inactive effector (E106A, 2 segments); Retron-Eco1-A2 8qbl M 58 2.66 38788717 469008 ugcgcacccuuagcgagaggccucuggauguugcggcauccugcauugaaucugaguu ...............<<<<..>>>><<<<<<<..>>>>>>>................. ..............(((((()))))(((((..()..)))))..).............. Retron-Eco1 filament with inactive effector (E106A, 2 segments); Retron-Eco1-msr 8qbl N 14 2.66 38788717 469008 cguaagggugcgca .............. .............. Retron-Eco1 filament with inactive effector (E106A, 2 segments); Retron-Eco1-A2 8qbl O 61 2.66 38788717 469008 ugcgcacccuuagcgagaggccucuggauguugcggcauccugcauugaaucugaguuacu ...............<<<<..>>>><<<<<<<..>>>>>>>.................... ..............(((((()))))(((((..()..)))))..)................. Retron-Eco1 filament with inactive effector (E106A, 2 segments); Retron-Eco1-msr 8qbl S 14 2.66 38788717 469008 cguaagggugcgca .............. .............. Retron-Eco1 filament with inactive effector (E106A, 2 segments); Retron-Eco1-A2 8qbl W 61 2.66 38788717 469008 ugcgcacccuuagcgagaggccucuggauguugcggcauccugcauugaaucugaguuacu ...............<<<<..>>>><<<<<<<..>>>>>>>.................... ..............(((((()))))(((((..()..)))))..)................. Retron-Eco1 filament with inactive effector (E106A, 2 segments); Retron-Eco1-msr 8qbl X 14 2.66 38788717 469008 cguaagggugcgca .............. .............. Retron-Eco1 filament with inactive effector (E106A, 2 segments); Retron-Eco1-A2 8qbl Y 14 2.66 38788717 469008 cguaagggugcgca .............. .............. Retron-Eco1 filament with inactive effector (E106A, 2 segments); Retron-Eco1-A2 8qbl b 61 2.66 38788717 469008 ugcgcacccuuagcgagaggccucuggauguugcggcauccugcauugaaucugaguuacu ...............<<<<..>>>><<<<<<<..>>>>>>>.................... ..............(((((()))))(((((..()..)))))..)................. Retron-Eco1 filament with inactive effector (E106A, 2 segments); Retron-Eco1-msr 8qbl c 14 2.66 38788717 469008 cguaagggugcgca .............. .............. Retron-Eco1 filament with inactive effector (E106A, 2 segments); Retron-Eco1-A2 8qbl R 61 2.66 38788717 469008 ugcgcacccuuagcgagaggccucuggauguugcggcauccugcauugaaucugaguuacu ...............<<<<..>>>><<<<<<<..>>>>>>>.................... ..............(((((()))))(((((..()..)))))..)................. Retron-Eco1 filament with inactive effector (E106A, 2 segments); Retron-Eco1-msr 8qbm C 61 3.09 38788717 469008 ugcgcacccuuagcgagaggccucuggauguugcggcauccugcauugaaucugaguuacu ...............<<<<..>>>><<<<<<<..>>>>>>>.................... ...............((((()))))(((((..()..))))).................... Retron-Eco1 filament with ADP-ribosylated Effector (full map with 2 segments); Retron-Eco1-msr 8qbm D 14 3.09 38788717 469008 cguaagggugcgca .............. .............. Retron-Eco1 filament with ADP-ribosylated Effector (full map with 2 segments); Retron-Eco1-A2 8qbm M 61 3.09 38788717 469008 ugcgcacccuuagcgagaggccucuggauguugcggcauccugcauugaaucugaguuacu ...............<<<<..>>>><<<<<<<..>>>>>>>.................... ...............((((()))))(((((..()..))))).................... Retron-Eco1 filament with ADP-ribosylated Effector (full map with 2 segments); Retron-Eco1-msr 8qbm N 14 3.09 38788717 469008 cguaagggugcgca .............. .............. Retron-Eco1 filament with ADP-ribosylated Effector (full map with 2 segments); Retron-Eco1-A2 8qbm O 61 3.09 38788717 469008 ugcgcacccuuagcgagaggccucuggauguugcggcauccugcauugaaucugaguuacu ...............<<<<..>>>><<<<<<<..>>>>>>>.................... ...............((((()))))(((((..()..))))).................... Retron-Eco1 filament with ADP-ribosylated Effector (full map with 2 segments); Retron-Eco1-msr 8qbm R 61 3.09 38788717 469008 ugcgcacccuuagcgagaggccucuggauguugcggcauccugcauugaaucugaguuacu ...............<<<<..>>>><<<<<<<..>>>>>>>.................... ..............(((((()))))(((((..()..)))))..)................. Retron-Eco1 filament with ADP-ribosylated Effector (full map with 2 segments); Retron-Eco1-msr 8qbm S 14 3.09 38788717 469008 cguaagggugcgca .............. .............. Retron-Eco1 filament with ADP-ribosylated Effector (full map with 2 segments); Retron-Eco1-A2 8qbm W 61 3.09 38788717 469008 ugcgcacccuuagcgagaggccucuggauguugcggcauccugcauugaaucugaguuacu ...............<<<<..>>>><<<<<<<..>>>>>>>.................... ...............((((()))))(((((..()..))))).................... Retron-Eco1 filament with ADP-ribosylated Effector (full map with 2 segments); Retron-Eco1-msr 8qbm X 14 3.09 38788717 469008 cguaagggugcgca .............. .............. Retron-Eco1 filament with ADP-ribosylated Effector (full map with 2 segments); Retron-Eco1-A2 8qbm Y 14 3.09 38788717 469008 cguaagggugcgca .............. .............. Retron-Eco1 filament with ADP-ribosylated Effector (full map with 2 segments); Retron-Eco1-A2 8qbm b 61 3.09 38788717 469008 ugcgcacccuuagcgagaggccucuggauguugcggcauccugcauugaaucugaguuacu ...............<<<<..>>>><<<<<<<..>>>>>>>.................... ..............(((((()))))(((((..()..)))))..)................. Retron-Eco1 filament with ADP-ribosylated Effector (full map with 2 segments); Retron-Eco1-msr 8qbm c 14 3.09 38788717 469008 cguaagggugcgca .............. .............. Retron-Eco1 filament with ADP-ribosylated Effector (full map with 2 segments); Retron-Eco1-A2 8qbt A 2841 2.2 RF02541 38503735 0003735 0005840 679895 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.<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<.....>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<..............>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<......>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<..<<....>>...>>>>>.>.....>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<.............<<............<<<<<<<......>>>>>>>...................>>....>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>.. .(((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((((.....)).))...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{......)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((.(....).)))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((((...........(..(....(.......((((((((....))))))))....)..............).)...)))).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).)))))))).. E. coli ApdP-stalled ribosomal complex; 23S rRNA 8qbt B 118 2.2 RF00001 38503735 0003735 0005840 679895 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))). E. coli ApdP-stalled ribosomal complex; 5S rRNA 8qbt i 1539 2.2 RF01959,RF00177,RF02542,RF01960 38503735 0003735 0005840 679895 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<<....>>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<.<<..<......>.>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<.......<<<....>>>......>>>>...<.<<<<.......<.<<<<<<<.........>>>>>>>.>.........>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<....>>>>>>....<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((.(((......))).)).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....(((.((..(......))).))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..(((........(((....))).......)))..((..((.....(....(((((((.........))))))).....)......)).....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...((((((....))))))....((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... E. coli ApdP-stalled ribosomal complex; 16S rRNA 8qbt 4 10 2.2 38503735 110321 gcgccgccag .......... .......... E. coli ApdP-stalled ribosomal complex; mRNA 8qbt 5 77 2.2 RF00005 URS00002E063F_83333 38503735 0030533 0006412 679895 cggcgaguagcgcagcuugguagcgcaacugguuugggaccagugggucggagguucgaauccucucucgccgacca <<<<<<<..<<<<.........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.........)))).(((((.......))))).....(((((.......)))))))))))).... E. coli ApdP-stalled ribosomal complex; Pro-tRNA 8qbt 6 77 2.2 RF00005 URS00002E063F_83333 38503735 0030533 0006412 679895 cggcgaguagcgcagcuugguagcgcaacugguuugggaccagugggucggagguucgaauccucucucgccgacca <<<<<<<..<<<<.........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((......[..))))..((((.......))))......(((((..]....)))))))))))).... E. coli ApdP-stalled ribosomal complex; Pro-tRNA 8qbt 7 76 2.2 RF00005 URS00005F0912_562 38503735 0030533 0006412 679895 ggggcuauagcucagcugggagagcgccugcuuugcacgcaggaggucugcgguucgaucccgcauagcuccacca .<<<<<...<<<<........>>>>.<<<<<.......>>>>>.....<<.<.......>.>>...>>>>>..... ..(..(...((............)).(((((.......)))))......(.(.......).)....).)....... E. coli ApdP-stalled ribosomal complex; Ala-tRNA 8qcq A 2745 2.3 RF02541 38503735 0003735 0005840 224308 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<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.....((.>>>.....<<<<<<<..<<<)).....>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<<<<<<<<.........>>>>>>>.>>.>>....<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<......<<.....>>.....>>>>...(((....<<<<<<<<....>>>>>>>>......<<<<<<<<.<<<<<<<<<.<<<.....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>.>>>>..>>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<....>>>>..................>>>>>>>>>>>.......<<<<..<<<<......>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<.<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>......>>>>>.>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<...<<<<<<<<<.....<<<...<<<<<<<<...<<<<<..>>>.>>...>>>>>>>>..>>.>.....>>>>.>>>>>..>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<..>>....>>>>>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<..>>>>>>....>>>>>>..<<<<<<<.<<......<<<<<.<<....>>.>>>>>...>>.>>>>>>>........>>>>>><......<<....<<<<<<.......>>>>>><<<<....<<<<<.<<<..<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<.<<<<<<......<<...<<<<....<<<<..<<<..<<<.<<<<<<<<...(((....>>>>>><<..<<<<<..<<<<<<<<<<<.<<.....>>>>>>>>>...>>>>..>>>>>...>><..<<..>>...>>>>>>...>>>...>>>>.........>>>>..>>..>>>>>>>>>>>>>>>.>>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<....<<<<....>>>>...>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>..<<<<.<<<..<<<<<<<..<<<<..<<...<<<<<..<<....>>...>>>>>...>>..>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>...>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<<.<<<.<<<<<...>>>>>.>>>....<<.<<<<<<.....>>>>>>>>.....>>>>>>>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.)))>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>. ((((((......((((((((((.....(((..(((((((((((((......((((((.....[[[)))...].((((((...(((]].....)))......))))))...)))....(((....)))(((((((......))))))).(((((((((.........))))))).)).))....((((((.....(...[..)......))))).).........((....))...((((......((.]...)).....))))...((((...((((((((....))))))))....{.((((((((.(((((((((.(((...(.((((......)))))[[(...).(((.....]])))...)))...))))))))).))))..)))))....((((((((..[......))))))))....}.(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((..((((..[...))))..)))).<.(.(........).).((((((....(((((((.(((((..(((...(((.....)))...)))...((....))..((((.....))))......))))).)))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)<)))...(((.(((((.......A))))))))..).))))))))).(.(((....[)))...).]))))))......).))..((((((....(((((....)))))(((((((((..((((((((((.....(((...((((((((...(((((..))).))...))))))))..)).).....)))).))))).)))))))).))..(((((((.((......)).)))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{..........)))))))))).))...........]]].)...))))))))))...)))))))((((((()))))))....))))))(.(((((...((......(((((.((....))])))))...))...)))))..).....))))))(......((....((((((.......))))))((((....(((...((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((.((((((......((...((((....((((..(((..(((.((((((((....{{....))))))((..(((((..(((((((((((.((.....)))))))))...))))..)))))...))(..((..))...))))))...)))...))))(..).....))))..))..))))))))))))))).))).....((......))..))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.[..).....)))))(((((....((((....))))...)))))(...).......(((((((((.>.((.........))...(((((((.....(((....))).......))))))).]((((.(((..(((((((..(((...((...(((((..((....))...)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).[..(((((.....>].)))))..((((((((.(((.((......((((.((((((..(((((.(((((((((.(((.(((((...))))).)))....((.((((((.....)))))))).....)))))))))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..a.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((....))))....(((.(((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))....)))...))))))). B. subtilis ApdA-stalled ribosomal complex; 23S rRNA 8qcq B 112 2.3 RF00001 38503735 0003735 0005840 224308 ugguggcgauagcgaagaggucacacccguucccauaccgaacacggaaguuaagcucuucagcgccgaugguagucggggguuucccccugugagaguaggacgccgccaa <<<<<<<....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<.......<<.<<<<<...>>>>>.>>.......>>..>>>>>>>. (((((((....((((((((.....((((((...(.....)...))))..))....)))))).)).((.......((.(((((...))))).)).......))..))))))). B. subtilis ApdA-stalled ribosomal complex; 5S rRNA 8qcq a 1533 2.3 RF01959,RF00177,RF02542,RF01960 38503735 0003735 0005840 224308 ggagaguuugauccuggcucaggacgaacgcuggcggcgugccuaauacaugcaagucgagcggacagaugggagcuugcucccugauguuagcggcggacgggugaguaacacguggguaaccugccuguaagacugggauaacuccgggaaaccggggcuaauaccggaugguuguuugaaccgcaugguucaaacauaaaagguggcuucggcuaccacuuacagauggacccgcggcgcauuagcuaguuggugagguaacggcucaccaaggcgacgaugcguagccgaccugagagggugaucggccacacugggacugagacacggcccagacuccuacgggaggcagcaguagggaaucuuccgcaauggacgaaagucugacggagcaacgccgcgugagugaugaagguuuucggaucguaaagcucuguuguuagggaagaacaagugccguucgaauagggcgguaccuugacgguaccuaaccagaaagccacggcuaacuacgugccagcagccgcgguaauacguagguggcaagcguuguccggaauuauugggcguaaagggcucgcaggcgguuucuuaagucugaugugaaagcccccggcucaaccggggagggucauuggaaacuggggaacuugagugcagaagaggagaguggaauuccacguguagcggugaaaugcguagagauguggaggaacaccaguggcgaaggcgacucucuggucuguaacugacgcugaggagcgaaagcguggggagcgaacaggauuagauacccugguaguccacgccguaaacgaugagugcuaaguguuaggggguuuccgccccuuagugcugcagcuaacgcauuaagcacuccgccuggggaguacggucgcaagacugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggucuugacauccucugacaauccuagagauaggacguccccuucgggggcagagugacagguggugcaugguugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuugaucuuaguugccagcauucaguugggcacucuaaggugacugccggugacaaaccggaggaagguggggaugacgucaaaucaucaugccccuuaugaccugggcuacacacgugcuacaauggacagaacaaagggcagcgaaaccgcgagguuaagccaaucccacaaaucuguucucaguucggaucgcagucugcaacucgacugcgugaagcuggaaucgcuaguaaucgcggaucagcaugccgcggugaauacguucccgggccuuguacacaccgcccgucacaccacgagaguuuguaacacccgaagucggugagguaaccuuuuaggagccagccgccgaaggugggacagaugauuggggugaagucguaacaagguagccguaucggaaggugcggcugg ...<<<<..[.((((.>>>>.<<<<.<<<<<...<<<<<<<.....<<<.<<<..<<<..<<.<<<<...<<<..<..>..>>>...>>>>.>>>>>......<<........<<<<<....<<...<<<<<<<.<<<<......<<<<<....>>>>>.......>>>>.....<<<<<<<<<<....>>>>>>>>>>.....<<<<<......>>>>>.>>>>>>>..>>.>>.>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>...<<<<..<....<.<...>..>....>.>>>>...<<<<<<<.........<<<<<<.<........>>>>>>>..........>>>>>.>..>..<<<<<((....<<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<.......<<<<<<.....>>>>>>.....>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<......>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<....<<<<<....>>>>>...<<<<...>>>.>>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<......>>>>>...>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<..<<<<....<.<<<<..<<<..<<<...>>>.>>>.>>>>.>...>>>>..>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.. ...((((..[.[[[..)))).(((..(((((...((((((((....(((.(((..(((..(..((((...(((.(....).)))...))))..))))......(((.......(((((....((...(((((((.((.......((((((....))))))........)).....(((((((((......))))))))).....(.(..........).).)))))))..)).)).))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))).....(.......((........))......)....(...((((...(.......((((..(.....)..)))).......)....))))......).((((.......(((((.....((....)).......))))).))))..))))).)))..........((([[...(.((((...(((.(((((((.(((((((.((.......((.((.....)).))....).).)))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((......))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((....(((((....)))))...(.(.....)..)))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..((......)))))...)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((..((((....(.((((..(((..(((...))).))).)))).)...))))..))))))..))).))))..).))...)..)..(((((((((....)))))))))}. B. subtilis ApdA-stalled ribosomal complex; 16S rRNA 8qcq y 77 2.3 RF00005 38503735 0030533 224308 cgggaaguagcucagcuugguagagcacaugguuugggaccauggggucgcagguucgaauccugucuucccgacca <<<<<<<..<<<<.........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))).... B. subtilis ApdA-stalled ribosomal complex; Pro-tRNA 8qcq w 77 2.3 RF00005 38503735 0030533 224308 cgggaaguagcucagcuugguagagcacaugguuugggaccauggggucgcagguucgaauccugucuucccgacca <<<<<<<..<<<<.........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))).... B. subtilis ApdA-stalled ribosomal complex; Pro-tRNA 8qfd 5 3130 2.2 RF02543 38383789 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccggcgcgggacauguggcguacggaagacccgggggcccaaguccuucugaucgaggccccguggacggugugaggccgguagcggcccccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcccggcaacccggcggcgccgccgccgggcgcauuuccaccgccgcgaccggcuccgggacggcugggaaggccggggaaggugaguguuacagccccggcagcagcacucgccgaaucccggggccgagggagcgccgcgcucuccccgggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgcaccgggcgggucgcgccgucgggcccggggggccacgagcgcacggggucggcggcucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcuacgaaagccgccguggcgcaaugaaggugaaggugggaucccgaggccgccgagggcgcaccaccggcccgucucgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagagucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucuccgcaguuuuauccgguaaagcgaaugauuagaggaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccaaaaagguguugguugauucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggaucggcgaucgaaagggagucggguucagauccccgaauccggagcggagaugggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcggcuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacaugagagguguagaauaagugggaggcggccgccggugaaauaccacuacucugaucguuuuuucacugacccggugaggcggggguucuggcgccaagcgcccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauaagcgccccucgguuggccucggauagccggccggugcggagugcccucguccugggaaacggggccggaaaggcggccgccgcccgucacgcaccgcacguucguggggaggcgcuaaaccauucguagacgaccugcuugggucgggguuucguacguagcagagcagugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<<...<<<<<<<<..>>>>.>>>>.....>>>>>..<<<<<<<<<<<<<<<<<....<<<<......>>>>.((......<<<.....))>>>...>.>>>>>>>>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<......>>>..................................<<<<<<<<..<<<..........<<<<<<<<<<.>>>>>>>>>>............<<<<<<<<<<<<<<<<<<<<<<<...<<..<<..<.....<....>.......>....>>........>>>>>>..>>>>>>>>>>>..........<<<<<..<<<.>>>.<<<<<<.<<<<.<<<<<<<<<<<<<<<<<<<<.<<<.<<<<....>>>>.>>>.>>>>>>>.>>>>>>>>>>.>>>...>>>>>>>>.>>>>>>>.....>>>.>>>>>.>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<.....>>>>.....>>>...<<....>>...<<<<<...<<<..<<<.>>>..>>>....>>>>>.<<<<<<<<<.<...>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<.>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<...<<<.<<<<<<<<<...<<<....<<<..<.<<<..>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.........>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<.........<<<.<<<<<<<<<.>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<.............>>>>>>>>>....>>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<..>.....>>....>>>..<<<<<........>>>>>))<<<<.<<<<<..<<<<..>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<......>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<..<<<.....<<<<....>>>>.....>>>>>>>>..>>>>>...........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<<<<<<.<<<<..........<<<<<..<<...>>............>>>>>.>>>>.>>.>>>>>>>>>>...<<<<<.....<<<<..............<<<<<<<..>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))].....<<<<<<<..<<<..)))))).>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>........<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>.....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<]]].>>>>>..>>.>>...>>>>...>>>><<<<....<<<<<...........>>>>>....>>>>.>>>...>.>>>>>>.<<<<<<<<<<....<<<........<<<<..>>>>.......>>>..<<<..<<<<........<<<......>>>......>>>>..>>>..............>>>>.>>>>>><<<<<.<.............>..<<.<<<<<<<.<<.....<<<<....<<<.>>>...>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..(((((((((..)))).))))....))))....(((((((((((((((((..({((((......)))))[[(...).(((....}]])))...).))))))))))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((......(...(..(((((((.)))))))..)..........).(((((((((((((((((((((((...((..((((......(....).......)...)))........))))))..)))))))))))..........(((((..(((.)))..(((((.((((.((((((((((((((((..((.(((..(((....)))..))).))..))).)))))))))).)))...)))))))).).))))).....))).))))).)))...)))))))).[((((........))))((((((....(((((((((((((..(((..(((((.....))))..)..)))...((....))...(((((...(((..(((.)))..)))....))))).(((((((((......))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((.))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((...(((.((((((((....(((....(((..(.(((..))).)..)))..)).)....))))))...(((((((((.(......))))))))))....))))))))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.(((((......(.........(((.(((((((((.))))))))))))..........]]].)....))))))))))...)))))))((((((.(((.............)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((..(((((((...((.....)).))))))....[[(((.((...((....(((....)))...(.)....(()).....))....))...(((((........)))))]]((((.(((((...(((())))..((((....)))...(...((((((...(((((((((((((((((((((((..{{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).))).))).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((..)..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(.)........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.(((((((((.(((((((.((.(.((((.......[..(((((...(....)..........].))))).)))).)..)).)))))))...(((((.....((((..............(((((((())))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}}.)))))..)).))...))))...)))).((((...((((.............))))...))))..)))...).)))))).((((((((((.(..(((........((((())))).......)))..(((..((((........(((......)))......))))..)))...........)..)))).))))))(((((.(..(.......)..)..((.(((((((.((.....((((.(..(((.)))..)))))....))....)))).))).))..))))).. UFL1 E3 ligase bound 60S ribosome; 28S rRNA 8qfd 7 119 2.2 RF00001 38383789 0003735 0005840 9606 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))). UFL1 E3 ligase bound 60S ribosome; 5S rRNA 8qfd 8 144 2.2 RF00002 38383789 0003735 0005840 9606 gacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggcgaucaucgacacuucgaacgcacuugcggccccgggcccggggcuacgccugucugagcgucgcu ........................................<<<<<<<<<....>>>>.....<.<<<......>>.......>>>..>...>>>....<<....>><<<<<<<<<>>>>>>>>>.................... ........................................((((((.[[.....))).....(.(((......]].......)))..)...)))....((....))((((((((())))))))).................... UFL1 E3 ligase bound 60S ribosome; 5.8S rRNA 8qhu S4 68 2.72 347515 gcgcggauagcucaguguagagcaggggauauccccguguccuuggucgauuccgaguccgcgcacca <<<<<<<..<<<<......>>>>.<<<<<..>>>>>.....<<<<<......>>>>>>>>>>>>.... (((((((..(((........))).(((((..))))).....((.((......)).))))))))).... CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME : LM32Cs1C1 snoRNA overexpression; E-site_tRNA_chain_S4 8qhu S1 1847 2.72 RF01960,RF02542,RF01959,RF00177 0003735 0005840 347515 gaucuggnugauucugcnaguagucaunngcuuguuunaaggacuuagccaugcaugccucagaaucacugcagcaggaaucugcgcauggcucnuuaaaucagacguaaunugccgcaaaaaucuugcggcgcaaaauuggauaacuuggcgaaacgccaagcuaauacaugaaccaaccggguguucuccacgugagacgcccagcgaaugaaugacaguaaaaccaaugccuuggcaguaacacccagcaguguugacucaauucauuccgugcgaaagccggcuuuccggcgucuuuugacgaacaacugcccuaucagcuggugauggccguguaguggacugccauggcguugacgggagcgggggauuaggguucgauuccggagagggagccugagaaauagcuaccacuucuacggagggcagcaggcgcgcnaauugcccaaugucaaaacaaaacgaugaggcngcgaaaagaaauagaguugucuugucauuucaaugggggauauuuaaacccauccaauaucgaguaacaauuggangacaagucuggugccagcacccgcgguaauuccagcuccaaaagcguauauuaaugcugungcuguunaaggguucguaguugaacugugggcugugcagguuuguggucguuggugacccaggcccuugcngcccgugaacaaagaaacaagaaacacgggagugggucgcaugucaugcaugcgggcguccgugauuuuacugugacuaaagaagcgugacuaaagcagucauuugacuugaauuagaangcaugggauaacaanggagcnuuuuuaaagguuauuggagnuuauggagcugugcgacaaaugcuuucccaucucggugugguuuagucggccucuaggaaugaaggaggguaguucgggggagaacguacuggggcgucagaggugaaauucuuagaccgcaccaagacgaacuacagcgaaggcauucuucaaggauaccuuccucaaucaagaaccaaaguguggagaucgaagaugauuagaaaccauuguaguccacacugcaaacgaugacacccaugaauuggggauaucuuuucagcacguuuucuguuuuuuacgcgaaagcuuugagguuacagucucaggggggaguacguucgcaanagugaaacuuaaagaaauugacggaauggcaccacaagacguggagcgugcgguuuaauuugacnnaacacngggaacuuuaccagauccggacaggaugaggauugacagauugaguguucuuucucgauucccugaauggngnugcauggccgcuuauggucggugnagugauuuguuugguugauuccgucaacggacgagauccaagcugcccaguagaauucagaauugcccauaggauagcgcauucggucgaauucuucucugcgggauuccuuuguauuugcacaaggugaaauuuugggcaacagcangucngugaugcuccucaauguucugggcgacacgcnnacuacaaugucagugagaacaagaaaaacgacucgaaccuacuugaucaaaagaguggggaaaccccggaaucacauagacccacuugggaccgaggauugcaauuanuggucgcgcaacgagnaaugucucguaggcgcagcucaucanacugugccgauuacgucccugccauuuguacacaccgncngucguuguuuccgaugauggugcaauacaggugaucggacaggcgcccgaaaguucaccgauauuunuucaauagagnaagcaaaagucguaacaagguagcuguaggggnnccugcagcugggacauuuu ...<<<<<.{.((((>>>>><<<<.<<<<<<...<<<...<......<<<.<<<..<<....<<....<<<<.>>>>...>>.>>......<<........<<<..<<..<<...<<.<<.....<<<<<.>>>>>...<<.....<<<<<<.....>>>>>>......>>..........<<<<<.<<<<.....>>>>>>>>>.<<<<<<<<<<.....((.((.{..{<<<..>>>.........................>>>>>>>>...>>....<<<<<....>>>>>...>>.>>..>>>>..>>>.<<<....<<<....<<<<<.<<.......>>.>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<.<<<..........>>>.>>.<<<<<..>>>>>...>>>>>>.........<<<....<<<..........>>>..>>>..>....>>>....<<<.<<......>>.>>>.....<<<<............>>>.....>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>>>>>.........<<<[[.....<<<<...<<<.......<...<<.<.......<<.<.......>.>>.......>.>>...>....................<...............<<<<.......>>>>.........>....<<<<<<<<.......<<...<.......>..<<<....>>>.....>>......>>>>>..>>>...........<<.<<.<<......}..}.)).))...>>.>>.>>..............<...<.<..>.>......>..................<<<<<..<<...<<<<<<<<..<<<<.<<<...<<<......>>>......>>>.>>>.>.>>.......<<....>>.>>>>>>..>>.>>>.>>....>>>...>>>>...<<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>>.........<<<.<<.<.<...<<<<<<................>>>>>>...>.>..<<..]]>>.....>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..)))).}<<<<<.<<<<<<<..<<.<<<<<<..<<.<<<<<<<......<<........>>..........<<<<<......<<<<.........<<.<<<........>>>.>>.......>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<<<.....<<<<<<<.<<<<.................>>>>....>>>>>>>.....>>>>....<<<<.<<......>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>.......>>>>>...>>.>>>>>.>>.....<<<.<<<.......<.....<<<.>>>..<<<<<<<........>>>>>>>....>........>>>...>>>......<....<<<..<..........>..>>>.....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<<<<<..<<.<<<.<.<<<<..<<<<<.<...<.<<..>>.>...>.>>>>>..>>>>.>.>>>.>>..>>>>>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.......... ...((((..[..[[..))))((((.((((((...(((...((.....(((.(((..((....((....((((.))))...)){))......(((.......(((..((..((...((.((.....(((((.)))))....(.....((((((.....))))))......)...........(((((.(((((..).))))))))).((((((((((........[[.[..[(.(..).)................(......).))))))))...))....(((((....)))))...)).))..))))..))).(.(....(((....(((((.((.......)).))))))))......).)..(((.((((....))))....)))))).((.(((..........))).)).((((....))))...)))))).).....(.(((...((((.}........))).))))).)....)))....((..((.(..).))..)).....((((............))).....).........((((([[....(.(.((.....((..]])).......)).)))))))..))))))))))..{......((({{...(.((((...(((..(....(......(.......(.............).......)......)....................(...............((((.......)))).........)....((.(((((.......((..((.......))...(....).......))......)))))...))........(..((..(.((......]..].]]......)).)..))..................(.(..).)..............)...)....(.(.(((..((...(((((((((..(((.(((...((........))......))).)))..))).......((....)).))))))..)).)))..)...))))...))))....((((((....(...((((.........))))...).))))))......<...(((.((.........((((................))))..........((..}})).....))...}.))))))).(((......((((....))))....)))...]]..]((((..(.(((((..((..(((((..((.(((((((.......(........)...........(((((.(.....(((......(..((.(.(........).).))....)..)))....((..(....(.((((((....(((.(.(((....)))....((......)).....).))).....((((.((((..(..(((.(((((.((.................)).)..).))).)))..)..))))..(.((((.((......))))))....)..)))).....))).))).....)..).)).....).)))))...)).))))).)).(...(((((((.......(.....(((.)))..((.((((........)))).))....)........))).).)))......(....((...(..........)...)).....)..)..))))).....(((((((.........)))))))......))...))))).).)).))..(.(..((.(.((((((((..((.(((.(.((((..(((((.(...(.((..)).)...).)))))..)))).).))).))..))))))))..).))...)..)..(((((((((....)))))))))>......... CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME : LM32Cs1C1 snoRNA overexpression; SSU_rRNA_chain_S1 8qhu 4 184 2.72 RF02543,RF02540,RF02541 0003735 0005840 347515 gugagauugugaagggaucucgcagguaucgugagggaaguaugggguaguacgagaggaacucccaugccgunccucuaguuucugggguuugucgaacggcaagugccccgaagccaucgcacggugguucucggcugaacgccucuaagccagaagccaaucccaagaccagaugcccacu <<<<<<<.........>>>>>>>.<<<<<<....<<<<.<<<<<<<<...............>>>>>>>><<<<<...<.<<....<<<<<<<<<......>>>>..>>>>>...>>.>..>>>>>.<<<<....<<<<...........>>>>....>>>>.>>>>.......>>>>>>.... (((((((.........))))))).(((((((...(((..(((((((......(....).....)))))))(((((...(.((....((((((((((....)))))..)))))...)).)..)))))...((....(((.............)))....))....))).....).)))))).... CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME : LM32Cs1C1 snoRNA overexpression; SR2_chain_4 8qhu 6 71 2.72 347515 aucgaaucgccaccuacaagacuggagcuugcucccucgaaggcgccaaguauauucaugaucacaagaca ......<.<<<............<<<<<..>>>>>......>>>........................>.. .......((((............(((((..)))))(..)..))).......................)... CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME : LM32Cs1C1 snoRNA overexpression; SR6_chain_6 8qhu 8 119 2.72 RF00001 0003735 0005840 347515 gaguacgaccacacuugagugaaaacaccauaucccguccgauuugugaaguuaagcacucacaggcucaguuaguacugaggucagugaugacucgggaacccugagugccguacucc <<<<<<<......<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<......<<<<<..<<....>>.>>>>>.....>>>>>>..>>>>>>>. (((((((.(....((((((((.....((((((...(....)...))))..))....)))))).))(.((((......(((((..((....)).))))).....)))).)).))))))). CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME : LM32Cs1C1 snoRNA overexpression; 5S_rRNA_chain_8 8qhu 1 1646 2.72 RF02543,RF02540,RF02541 0003735 0005840 347515 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CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME : LM32Cs1C1 snoRNA overexpression; RNA (1646-MER) 8qhu 3 178 2.72 347515 gugguaangcgaacacuugccagguaacaaaucaauccucccacggugagcuuucuuuucaccauaauccaccuugggccuuuuuaccgcguuguucggagcgggggcucaagauugaaaaaugcagcucuguacugucauugugaguucugcgcauuaaagcaaaaaccuggggugu <<......>>....<<<..<<<<<<.......<<...<<<.<<.<<<<<<.......>>>>>><...<<.<.<<<<<<<<<<<....<<.......>>....>>>>>>>>>>>.>.>>....>..<...........>...>>.>>>...>>...............>>>>>>>>>.. (((....)))....(((..((((((.......((...(((.((.((((((.......))))))(...((.(.(((((((((((....((.......))....))))))))))).).))....)..(...........)...)).)))...))...............))))))))).. CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME : LM32Cs1C1 snoRNA overexpression; SR1_chain_3 8qhu 5 117 2.72 347515 uacgucccucuccaaacgagagaacaugcaugggcuggcaugagcggcugcuuuucggggggcucgcgucccgaggcgcugaaccuugaggccugaaauucaugcucagggacacua ...<<<<<<<<<.......>>>>....<<<<<<<<.<<.....<<<..<<.....>>...<<..<..>..>>....>>>....>>.....>>>.......>>>>>...>>>>>.... ...(((((((((.......)))).....(((((((.((.....(((...(.....).....(..(())..).....)))....)).....))).......))))....))))).... CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME : LM32Cs1C1 snoRNA overexpression; SR4_chain_5 8qhu 7 163 2.72 RF00002 0003735 0005840 347515 aacgugncgcgauggaugacuuggcuuccuauuucguugaagnacgcaguaaagugcgauaagugguaucaauuncagaaauucaauuaccgaaucuuugaacgcaaacggcgcaugggagaagcucgugucauccccgugcaugccauauucucngugucga .........................................<<<<<<<<<....>>>>.....(<<<<......>>...........>>>>.)...>>>....<<.....>><<<<<<<.<..<<....>>..>.>>>>>>>..................... ..........................................(((((.[[.....))).....(((((......]]...........)))).)...)).....((.....))(((((((....((.().))....)))))))..................... CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME : LM32Cs1C1 snoRNA overexpression; 5.8S_rRNA_chain_7 8qhu 2 1190 2.72 RF02543,RF02540,RF02541 0003735 0005840 347515 cccaacugcagaccguacucaucaccgcaucagguccccaagcauagaaugcucugguacauagagaaangnacacucagggaagucggcaaanuagaugcguaaguucgcaagaagcauuggcucugagggcaaaaauugccaacucagaacugnuuacggcggggaauccaacugunuaauuaaaacauagguuugugaugcauccaagugguguauaucgcaaacugauuucugccnagugcucugaaugucaacgugacgagauucaccgacgcgcggguaaacggcgggaguaacuaugacucucuuaagguagcnaanugccucnucuuccaauuagagacgcgcaugaanggauuaaugngnuucccucugunccgaguuncuaucuagcgaancgacagucaagggaacggacuugnagggcuaagcggngaaagaagacccunuugaguuugacnccagucuggcucugugcggcgacaucugaggguaggguggaagcgcaagcgcaaaugaaauaccaccacucggaacguugcuucacuuaucgaaugaagagaccaauggguugcguagucuucgggcuaugcaccgucuagguuugggagugucccccuguggguacccaaccgugcuguaaacugaaccaacgggaucaguuccggagucuuguuucgagacaucugccagauggggaguuuggcugnggcggcauaucuguuacacgacaacgcaggnnuccuaaggcgagcucagugggaacagaaaucucacguagaacacaagcguaaaagcuugcuugauuaacgauuuccaguangaaucgagacugcgaaagcaaggccngcgauccuuugcgaagaauaggaaauaugaacaaaucauaccanangugucagaauaauuacnacagngauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuungaugucggnucuuccuaaccuagcgccgcagaagacgcuaaggguuggaunnuucacccacugncagggaacgugngcuggguuuagancgucgugagacagguugguuunacccuacuuagcuggaaauugcgagaaaaagauuauccgugcaaagcggacgucgggucguugggccuggcgagcgguggguaguacuugguacgcucaucacc ........................<<......>>......<<<<.....>>>>........<<<<....<<<<.<<<<.<<.........<.....<<<<<...............>>>>><<.<<<<<<<<<<<...>>>>>..>>>>>>.>>..........<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<....<<<<......>>>>....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>>.>>>>............<<<<<........>>>>>..<<<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<...<<<.<<<<<<.<<<.<<......................................>>.>>>..>>>>>>.>>>...<<<<<.....<<<<....<<...<<<<<<<<....>>>>>>>>.>>.....<<<<.<<.....<<.......>>...>>.>>>>...................<<<<<....>>>>>..>>>>...>>>>>.......>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<......>>....>>>>>>>...<<...<<<<<.......>>>>>..>>.<<<....>>>.>>........<<<<<<..............<<<<.......>>>>.>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>........<<<<.<<<<<<..<<<<<<<.<......>.>>>>..>>>.<<<.........>>>.....>>>>>..>...>>>.>.....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>>>.......................<<<<.....>>>>.<<<<<<<<<....>>>>>>>>>.<.<<<<<<<.<<<<...>>>>>>>>>>>.>. ........................((......))......((.(.....).))........(.((.....(((.((.(.((..(....(.......(((((....(.[..).....)))))((.(((((((.(((...))).)..)))))).))..........(((((((((...((.........))...(((((((....((((.....))))......))))))).].(.(.(((..((((((.....((....(((........)))....))..))))..)))))(.(.(.........).).)........((..........(((((.......)))))..)..)....).)....)).))))))).)..))).).)))))..)).).........[..((.((......].)).))..(((((((..(((.((......((((.(((((...(((((.((.((((...((..((((((.(((.((............((....))..................)).)))..))))))..))...(((((......(((....(....((((((((....))))))))..)..(..(((..((.....((..(..).))...))..)))..)................((((......))))..)))....))))).......)))).))..)))))..(((......[)).)(((.(...........].).)))([((...(((.(((.(.((((((.......))))))...).((][..[.))....))).))).(......(((.(.......).)))....)(((....))).)).].].....((.((.(............(((.........)))))).))....)......)))..)))))).......(....(.((((((...((.......))...))))))...)....)........((((.((((((..(((((((.(......).))))..))).(((.(.....).))).....)))))..)...))).)......((((((....))).))).....))..))).)))))))........................(((.....)))..(((.(((((....))))).))).(.(((((((.((((...))))))))))).). CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME : LM32Cs1C1 snoRNA overexpression; LSUb_rRNA_chain_2 8qie 1 1611 2.43 RF02543,RF02540,RF02541 0003735 0005840 347515 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......................(((((......(...[..).......)))).).........((....))...((((.......((.]...)).....))))....((.(...(.(..((((((((......))))).))....)).)...((((...((((((((.(((((....(.((.......((((.......)))).....((........)).......)))[[(...)..((.....]])).....)))))...)))..))))).)))).......)....(((((((........)))))))......(((((........)))))...))....................................((....)).............(..((.(....).))............)......................((..(((((..(((((....(.((((.((((.(((....((((...(.(((.((..........)).))).)......).))).....)))...))))........((((......((((((..(.((.(.).))...)..).))).))...)))).....[[[[...))))).....))))).)))))..))..(((..........)))((((.(....(((((.(.(((((..(((..(((.((.(.)..)))))..)))...((....))..(((((.....)))))...(((((...((.(((((......))))).))....)))))(((((((((.....)))))).)))...))))).).)))))...(.(...((((((.....((((((((((..(((...(.(.(((....))).).)...).))....(((..((.((........)))).)))..).))))))))).(.((.......))...)..))))))......).)...((((((....(.(((....))).).((((((((.....((.(.(.((((....(((.....(.....(.(..).).....)...)).)....)))).).....(((.(((((.((.....))))))))))..........)))...))))))).)...((((.((.((.....)).)).))))....((........))...((((((....((([[[...(..(..((((........(...........(((((((.((...)).)))))))...........]]].)....)))).))........)))....))))))((((.(((((..........]]]].........)))))))))....))))).)(.((((.(((.(......((((..(((....))).))).)...).))).))))..).....).))))..............(((((((.......(.......)....)))))))....................(((((....((.....))..)))))....((......(...((.(.(((......))).................(...).......).))....).....((((.........))....)).))........... CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME : LM32Cs1C1 mutant snoRNA overexpression, class 4; LSUa_rRNA_chain_1 8qie 2 1159 2.43 RF02543,RF02540,RF02541 0003735 0005840 347515 ccaacugcagaccguacucaucaccgcaucagguccccaagcauagaaugcucngguacauagagaaangnacacucagggaagucggcaaanuagaugcguaaguucgcaagaagcauuggcucugagggcaaaaauugccaacucagaacugnuuacggcggggaauccaacugunuaauuaaaacauagguuugugaugcauccaagugguguauaucgcaaacugauuucugccnagugcucugaaugucaacgugacgagauucaccgacgcgcggguaaacggcgggaguaacuaugacucucuuaagguagcnaanugccucnucuuccaauuagagacgcgcaugaanggauuaaugngnuucccucugunccgaguuncuaucuagcgaancgacagucaagggaacggacuugnagggcuaagcggngaaagaagacccunuugaguuugacnccagucuggcucugugcggcgacaucugaggguaggguggaagcgcaagcgcaaaugaaauaccaccacucggaacguugcuucacuuaucgaaugaagagaccaauggguugcguagucuucgggcuaugcaccgucuagguuugggaguccgucccccuguggguacccaaccgugcuguacugaaccaacgggauccggagucuuguuucgagacacugccagauggggaguuuggcugnggcggcauaucuguuacacgacaacgcaggnnuccuaaggcgagcucagugggaaucucacguagaacacaagcguaaaagcuugcuugauuaacgauuuccaguangaaucgagacugcgaaagcaaggccngcgauccuuugcgaagaauaggaaauaugaacaaaucauaccanangugucagaauaauuacnacagngauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuungaugucggnucuuccuaaccuagcgccgcagaagacgcuaaggguuggaunnuucacccacugncagggaacgugngcuggguuuagancgucgugagacagguugguuunacccuacuuagcuggaaauugcgagaaaaagauuauccgugcaaagcggaggcgagcgguggguaguacaugguacgcucaucacc .......................<<......>>......<<<<<...>>>>>........<<<<....<<<<.<<<<.<<...............<<<<<.....<..>......>>>>><<.<<<<<<<<<<<...>>>>>..>>>>>>.>>..........<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.....<<....<<<<......>>>>....>>..>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>>.>>>>............<<<<<........>>>>>..<<<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<...<<<.<<<<<<.<<<.<<.............<....>...................>>.>>>..>>>>>>.>>>...<<<<<.....<<<<....<<...<<<<<<<<....>>>>>>>>.>>.....<<<<.<<.......<<.<...>.>>...>>.>>>>.................<<<<.>>>>..>>>>...>>>>>......>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.>>>>>>.....<<......>>....>>>>>>>...<<...<<<<<.......>>>>>..>>.<<<....>>>.>>.........<<<<<..............<<<<.......>>>>.>>>>>..........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<<<<<<<.<......>.>>>>..>>>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>>>.......................<<<<.....>>>>......<.<<<<<<<.<<<<...>>>>>>>>>>>.>. .......................((......))......((.(.....).))........(.((.....(((.((.(.((..(....(........((((....(.[..).....)))).((.(((((((..((...))..)..)))))).))..........(((((((((...((.........))...(((((((....((((.....))))......))))))).].(.(.(((..((((((.....((....(((........)))....))..))))..)))))(.(.(.........).).)........((..........(((((.......)))))..)..)....).)....)).))))))).)..))).).)))))..)).).........[..((.((......].)).))..(((((((..(((.((......((((.(((((...(((((.(((((((...((..((((((..((.((.........(..((....)).............)....)).))...))))))..))...(((((.....((((....(....((((((((....))))))))..)..(..((((.((.......((.(...).))...)).))))..)..............(((...)))..))))...)))))......)))))))..)))))..(((......[)).)(((.(...........].).)))([((...(((((((.(.((((((.))))))...).((][..[.))....))))))).(......(((.(.......).)))....)(((....))).)).].].....((.((.(............(((.........)))))).))....)......)))..))))))............(.((((((...((.......))...))))))...).............((((.((((((..((.((((.(......).))))...))..((.(.....).))......)))))..)...))).)......((((((....))).))).....))..))).)))))))........................(((.....))).......(.(((((((..(((...))).))))))).). CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME : LM32Cs1C1 mutant snoRNA overexpression, class 4; LSUb_rRNA_chain_2 8qie 3 156 2.43 347515 gugguaangcggccagguaacaaaucaauccucccacggugagcuuucuuuucaccauaauccaccuugggccuuuuuacucucgcguuguucggagcgggggcucaagauugaaaaaugcauugugaguucugcguuaaagcaaaaaccuggggu <<......>>..<<<<<<.......<<...<<<.<<.<<<<<<.......>>>>>><...<<.<.<<<<<<<<<<........<<.......>>.....>>>>>>>>>>.>.>>....>....>>.>>>...>>.............>>>>>>... (((....)))..((((((...(...((...(((.((.((((((.......))))))(...((.(.(((.((.((((.......((.......))....)))).)).))).).))....)....)).)))...))..)..........))))))... CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME : LM32Cs1C1 mutant snoRNA overexpression, class 4; SR1_chain_3 8qie 4 184 2.43 RF02543,RF02540,RF02541 0003735 0005840 347515 gugggauugugaagggaucucgcagguaucgugagggaaguaugggguaguacgagaggaacucccaugccgunccucuaguuucugggguuugucgaacggcaagugccccgaagccaucgcacggugguucucggcugaacgccucuaagccagaagccaaucccaagaccagaugcccacu <<<<<<<.........>>>>>>>.<<<<<<....<<<<.<<<<<<<<...............>>>>>>>><<<<<...<.<<....<<<<<<<<<......>>>>..>>>>>...>>.>..>>>>>.<<<<....<<<<...........>>>>....>>>>.>>>>.......>>>>>>.... (((.(((.........))).))).(((.(((...(((..((((.((......(....).....)).))))(((((...(.((....((((((((.(....).)))..)))))...)).)..)))))...((....((...............))....))....))).....).)).))).... CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME : LM32Cs1C1 mutant snoRNA overexpression, class 4; SR2_chain_4 8qie 5 115 2.43 347515 uacgucccucuccaaacgagagaacaugcaugggcuggcaugagcggcaugcuuucgguggggcucgucccgaggcgcugaaccuugaggccugaaauuucaugcucagggacac ...<<<<<<<<<.......>>>>....<<<<<<<<.<<.....<<<...............<<......>>....>>>....>>.....>>>........>>>>>...>>>>>.. ...(((((((((.......)))).....((((.((.((.....(((................(..()..).....)))....)).....)).........))))....))))).. CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME : LM32Cs1C1 mutant snoRNA overexpression, class 4; SR4_chain_5 8qie 6 71 2.43 347515 aucgaaucgccaccuacaagacuggagcuugcucccucgaaggcgccaaguauauucaugaucacaagaca ......<.<<<............<<<<<..>>>>>......>>>........................>.. .......((((............(((((..)))))(..)..))).......................)... CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME : LM32Cs1C1 mutant snoRNA overexpression, class 4; SR6_chain_6 8qie 7 164 2.43 RF00002 0003735 0005840 347515 aacgugncgcgauggaugacuuggcuuccuauuucguugaagnacgcaguaaagugcgauaagugguaucaauuncagaacauucaauuaccgaaucuuugaacgcaaacggcgcaugggagaagcugugucauccccgugcaugccauauucucngugucgaa .........................................<<<<<<<<<....>>>>.....(<<<<......>>............>>>>.)...>>>....<<.....>><<<<<<<.<<.<<...>>..>>>>>>>>>...................... .........................................((((((.[[.....))).....(((((......]]............)))).)...)))....((.....))(((((((...............)))))))...................... CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME : LM32Cs1C1 mutant snoRNA overexpression, class 4; 5.8S_rRNA_chain_7 8qie 8 119 2.43 RF00001 0003735 0005840 347515 gaguacgaccacacuugagugaaaacaccauaucccguccgauuugugaaguuaagcacucacaggcucaguuaguacugaggucagugaugacucgggaacccugagugccguacucc <<<<<<<......<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<......<<<<<..<<....>>.>>>>>.....>>>>>>..>>>>>>>. (((((((.(....((((((((.....((((((...(....)...))))..))....)))))).))((((((......(((((..((....)).))))).....))))))).))))))). CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME : LM32Cs1C1 mutant snoRNA overexpression, class 4; 5S_rRNA_chain_8 8qie S1 1787 2.43 RF01960,RF02542,RF01959,RF00177 0003735 0005840 347515 gaucuggnugauucugcnaguagucauangcuuguuunaaggacuuagccaugcaugccucagaaucacugcagcaggaaucugcgcauggcucnuuaaaucagacguaaucugccgcaaaaaucuugcggccgcaaaauuggauaacuuggcgaaacgccaagcuaauacaugaaccaaccggguguucuccaugagacgcccagcgaaugaaugacaguaaaaccaaugccuucaguaacacccagcaguguugacucaauucauuccgugcgaaagccggcuuccggcgucuuuugacgaacaacugcccuaucagcuggugauggccguguaguggacugccauggcguugacgggagcgggggauuaggguucgauuccggagagggagccugagaaauagcuaccacuucuacggagggcagcaggcgcgcnaauugcccaaugucaaaacaaaacgaugaggcngcgaaaagaaauagaguugucuugucauuucaaugggggauauuuaaacccauccaauaucgaguaacaauuggangacaagucuggugccagcacccgcgguaauuccagcuccaaaagcguauauuaaugcugungcuguunaaggguucguaguugaacugugggcugugcagggcccuugcagcccgugaaaagaaacaagaaacacgggagugggucgcaugucaugcaugccagggggcguccgugauuuuacugugacuaaagaagcgugacuaaagcagucauuugacuugaauuagaaagcaugggauaacaaaggagcauuuuuaaaggauuggagauuauggagcugugcgacaaaugcuuuccucggugugguuuaaggaaugaaggaggguaguucgggggagaacguacuggggcgucagaggugaaauucuuagaccgcaccaagacgaacuacagcgaaggcauucuucaaggauaccuuccucaaucaagaaccaaaguguggagaucgaagaugauuagaaaccauuguaguccacacugcaaacgaugacacccaugaauuggggauaucuugaauauccucagcacguacgcgaaagcuuugagguuacagucucaggggggaguacguucgcaanagugaaacuuaaagaaauugacggaauggcaccacaagacguggagcgugcgguuuaauuugacnnaacacngggaacuuuaccagauccggacaggaugaggauugacagauugaguguucuuucucgauucccugaauggngnugcauggccgcuuauggucggugnagugauuuguuugguugauuccgucaacggacgagauccaagcugcccaguagaauucagaauugcccauaggauagcauucgggaauucuucucugcgggauuccuuuguaugcacaaggugaaauuuugggcaacagcangucngugaugcuccucaauguucugggcgacacgcnnacuacaaugucanugagaacaagaacgaaccuacuugaucaaaagaguggggaaaccccggaaucacauagacccacuugggaccgaggauugcaauuanuggucgcgcaacgagnaaugucucguaggcgcagcucaucanacugugccgauuacgucccugccauuuguacacaccgccngucguuguuuccgaugauggugcaauacaggugaucggacaggcgcccgaaaguucaccgauauuunuucaauagagnaagcaaaagucguaacaagguagcuguaggggnnccugcagcugggacauuu ...<<<<..[.((((.>>>><<<<.<<<<<<...<<<...<......<<<.<<<..<<....<<....<<<<.>>>>...>>.>>......<<........<<<..<<..<<...<<.<<.....<<<<<..>>>>>...<<.....<<<<<<.....>>>>>>......>>..........<<<<<.<<<<...>>>>>>>>>.<<<<<<<<<<.......[.[....................................>>>>>>>>...>>....<<<<<...>>>>>...>>.>>..>>>>..>>>.<<<....<<<....<<<<<.<<.......>>.>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<.<<<..........>>>.>>.<<<<....>>>>...>>>>>>.........<<<....<<<..........>>>..>>>..>....>>>....<<<.<<......>>.>>>.....<<<<............>>>.....>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>>>>>.........<<<((.....<<<<...<<<.......<...<<.<..<..>.>.>>...>..................<...............<<<<.......>>>>.............>....<<<<<<<<.......<<...<.......>..<<<....>>>.....>>......>>>>>..>>>...........<<.<<.<<..........].]....>>.>>.>>..............<.<..>.>...............<<<<<..<<...<<<<<<<<..<<<<.<<<...<<<......>>>......>>>.>>>.>.>>.......<<....>>.>>>>>>..>>.>>>.>>....>>>...>>>>...<<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>>.........<<<.<<.<<<..<<<<<<<<<<.<.>.>>>>>>>>>>..>>>..<<..))>>.....>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<.<<<<<<..<<.<<<<<<<......<<........>>..........<<<<<......<<<<.........<<.<<<........>>>.>>.......>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<<<.....<<<<<<<.<<<<...............>>>>..>>>>>>>.....>>>>....<<<<.........>>>>.......>>>>>....>>>.>>>.....>>>>>>>.......>>>>>...>>.>>>>>.>>.....<<<.<<<.......<......<<<<<<<........>>>>>>>....>........>>>...>>>......<....<<<..<..........>..>>>.....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<<<<<..<<.<<<.<.<<<<..<<<<<.<...<.<<..>>.>...>.>>>>>..>>>>.>.>>>.>>..>>>>>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[..[[..))))((((.((((((...(((...((.....(((.(((..((....((....((((.))))...))[))......(((.......(((..((..((...((........(((((())))))....(.....(.((((.....)))).)......)...........(((.(.(((.....)))).))).(((((((.((.......{......{...............................)).)))))...))....(((((...)))))......))..))))..))).(.(....(((....(((((.((.......)).))))))))......).)..(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(..(....(.((.]........))..).).).)....)))....(((.((......)).))).....((((............))).....).........((((([[....(.(.((.....((..]])).......)).)))))))..))))))))))..[......((([[...(.((((...(((..(....(.........(..)........)..................(...............((((.......)))).............)....((.(((((.......((..((.......))................))......)))))...))........(..(...(.((.....}......}....)).)...)................(..)......)...)....(.(.(((..((...(((((.((...(((.(((...(..........)......))).)))...)).......((....))..)))))..)).)))..)...))))...))))....((((((....(...((((.........))))...).))))))......{...(((.((..((..((((((((.(.(.).).))))))))..))...((..]])).....))...].))))))).(((......((((....))))....)))...]]..]((((..(.(((((..((..(((((..((.(((((((.......(........)...........(((((.(.....(((......(..((.(.(........).).))....)..)))....((..(....(.((((((....(((.(.(((....)))....((......)).....).))).....((((.((((.....(((.(((.(.((...............)).)..))).))).....))))..(.((((.........))))....)..)))).....))).))).....)..).)).....).)))))...)).))))).)).(...(((((((.......(......((.((((........)))).))....)........))).).)))......(....((...(..........)...)).....)..)..))))).....(((.(((.........))).)))......))...))))).).)).))..(.(..((.(.((((((((..((.(((.(.(.(.(.(((((.(...(.((..)).)...).))))))..).).).))).))..))))))))..).))...)..)..(((((((((....)))))))))}........ CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME : LM32Cs1C1 mutant snoRNA overexpression, class 4; SSU_rRNA_chain_S1 8qie S4 50 2.43 347515 gcgcggacaguagagcaggggauccccgugcuuggcgaguccgcgcacca <<<<<<<<....>.<<.<<<<..>>>>>>.<<<<.>>>>>>>>>>>.... ((((((((....)..(.((.(().))))..((((.))))))))))).... CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME : LM32Cs1C1 mutant snoRNA overexpression, class 4; E-site_tRNA_chain_S4 8qk7 2 1536 2.77 RF00177,RF01959,RF02542,RF01960 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaauucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggaucaccuccuua ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<..>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.............. ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((..))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))...(......)..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}............. E167K RF2 on E. coli 70S release complex with UAA; 16S rRNA 8qk7 4 26 2.77 562 uaaggagguauuaaauguaagaauuc .......................... .......................... E167K RF2 on E. coli 70S release complex with UAA; mRNA 8qk7 5 76 2.77 RF00005 0030533 562 gcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... E167K RF2 on E. coli 70S release complex with UAA; tRNA(fMet) 8qk7 1 2899 2.77 RF02540,RF02541,RF02543,RF00002 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcgcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<..>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<<.<<....>>..>>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<..<<<<...........<<<<<..<<.......<<<<<<<<....>>>>>>>>....>>............>>>>>..>>>>..>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((.(((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))))))).)))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((((((.....))))).))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{..((((.(((...(((.......)))...))).....(..(((......)))).))))....)))..))))).))...........]]].)...))))))))))...)))))))((((((((()))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((.(...((((.(..........((((..(((.......(((((((....)))))))....)))............)))).).))))...).)))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).).....((.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..))....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). E167K RF2 on E. coli 70S release complex with UAA; 23S rRNA 8qk7 3 119 2.77 RF00001 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>> ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))) E167K RF2 on E. coli 70S release complex with UAA; 5S rRNA 8qo9 2 98 5.29 RF00004 URS0000E60B66_9606 38383864 0045131 0000348 0005686 9606 cgcuucucggccaaguguaguaucuguucuuaucaguuuaauaucugauagauuuuuggagcaucgaccugguauugcaguaccuccaggaacggugc ...............................<<<<<.<....>.>>>>>...........<<<<<<.<<<<<.............>>>>>..>>>>>> ...............................(((((........)))))...........((((((.(((((.............)))))..)))))) Cryo-EM structure of a human spliceosomal B complex protomer; U2 snRNA 8qo9 5 115 5.29 RF00020 URS000075BAAE_9606 38383864 0000244,0000353 0005682,0046540 9606 acucugguuucucuucagaucgcauaaaucuuucgccuuuuacuaaagauuuccguggagaggaacaacucugagucuuaacccaauuuuuugaggccuugcuuuggcaaggcua .<<<...<<<<<<<<<<........<<<<<<<<...........>>>>>>>>...>>>>>>>>>>.......>>>...................<<<<<<<<....>>>>>>>>. .(((...((((((((((...((...((((((((.(.......).)))))))).)))))))))))).......)))....................(((((((....))))))).. Cryo-EM structure of a human spliceosomal B complex protomer; U5 snRNA 8qo9 Z 46 5.29 38383864 9606 ccuccgaacgguaagagccuagcauguagaagaugucauacuuauc .............................................. .............................................. Cryo-EM structure of a human spliceosomal B complex protomer; MINX pre-mRNA 8qo9 4 127 5.29 RF00015 URS00003F07BD_9606 38383864 0017070 0000244,0000353 0005687,0046540 9606 agcuuugcgcaguggcaguaucguagccaaugaggucuauccgaggcgcgauuauugcuaauacuuuucccaauaccccgccgugacgacuagucggcacuggcaauuuuugacagucucgagacug ...................<<<<<.<<<.....<<.....>>..>>>>>>>>...........................<<<<<<.<<<<..>>>>.>>>.>>>.........<<<<<<<>>>>>>> ...................(((((.(((.....((.....))..))))))))...........................((.(((.((((())))).)))..)).........((((((())))))) Cryo-EM structure of a human spliceosomal B complex protomer; U4 snRNA 8qo9 6 94 5.29 RF00026 URS000035C796_9606 38383864 0030621 0000244,0000353 0005688,0046540 9606 gugcucgcuucggcagcacauauacuaaaauuggaacgauacagagaagauuagcauggccccugcgcaaggaugacauucgugaagcguauuu <<<<<.<<....>>>>>>>........................................................................... (((((.((....)))))))........................................................................... Cryo-EM structure of a human spliceosomal B complex protomer; U6 snRNA 8qoa Z 76 2.0 RF00005 URS00001ACE3E_562 38503753 0030533 0006412 679895 gcgggaauagcucaguugguagagcacgaccuugccaaggucggggucgcgaguucgagucucguuucccgcucca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... .((((((..((((.....[..)))).(((((.......))))).....(((((..]....)))))))))))..... Structure of SecM-stalled Escherichia coli 70S ribosome; P-site tRNA-gly 8qoa b 119 2.0 RF00001 38503753 0003735 0005840 679895 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>> .(((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))). Structure of SecM-stalled Escherichia coli 70S ribosome; 5S rRNA 8qoa Y 77 2.0 RF00005 URS00002E063F_83333 38503753 0030533 0006412 679895 cggcgaguagcgcagcuugguagcgcaacugguuugggaccagugggucggagguucgaauccucucucgccgacca <<<<<<<..<<<<.........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))).... Structure of SecM-stalled Escherichia coli 70S ribosome; A-site tRNA-pro 8qoa a 2753 2.0 RF02541 38503753 0003735 0005840 679895 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagcgucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcgcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauauguucuaacguugaccccuaaucgggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<..>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<..>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<..<<....>>...>>>>>.>.....>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<..>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ...(((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((.((((.....))))..))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{........)))..))))).))...........]]].)...))))))))))...)))))))((((((((()))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((())))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).)))))).... Structure of SecM-stalled Escherichia coli 70S ribosome; 23S rRNA 8qoa A 1513 2.0 RF01959,RF00177,RF02542,RF01960 38503753 0003735 0005840 679895 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagaggggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggnnccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<...>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<..>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<.....<<<<....>>>>......<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((.....((..(((...)))))....)))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....(.(((..))).).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((.......(((....)))......))))..((.(((((...(....((((((.(.......).)))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((.....((((....))))......((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....(((..(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)...))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....(((((..((((...(....)..)))).)))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Structure of SecM-stalled Escherichia coli 70S ribosome; 16S rRNA 8qoi L5 3773 1.9 RF02543 38844527 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagngngaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcggcccggcggaucuuucccgcgcgggggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucgggggcccccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcgcucuccccccucccggcgcgccggggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccgggggaggccacgcgcgcgucccccgaagagggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccnucuugnnacncggaccaaggagunuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgagggugcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccnanagauggugancuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauagnggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcagacccgacgcccgccacgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcngaacuggcgnugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagcggcgggccggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaunuuggugguagunnnaaauauucaaacgagaacuuugaaggccgaaguggngaaggguuccaugngaacagnanuugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccnuauccgcagcaggucuncaaggugaacngccucuggnauguuggaacaanguagguaagggaagucggcaagcnggauccguaacuucnggauaaggauuggcucuaagggcugggucggucgcggccggcgccuagcagccgacuuagaacuggugcggaccaggngaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugccnagugcucugaaugucanagugangaaauucaaugaagcgcggnuaaacggcgggaguaacuaugacucucuuaagguagcnaanugccucnucaucuaauuagugangcgcaugaanggaugancgagnuucccacugunccuaccuacuauccagcgaaaccacngncaagggaacgggcuuggnggaaucagcggngaaagaagacccuguugagcuugacncuagucuggcacggugaagagacaugagagguguagaauaagugggaggcccccggcgcccccccgguguccccgcgaggggcccggggcgggguccgccggcccugcgggccgccggugaaauaccacuacucugaucguuuuuucacugacccggugaggcgggggggcgagccccgaggggcucucgcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacugnggcgguacaccugucaaacgguancgcaggnnuccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucagnacgaauacagaccgugaaagcggggccuuacgauccuucugaccuuuuggguuuuaagcaggangugucagaaaaguuaccacagngauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuungaugucggnucuuccuaucauugugaagcagaauucaccaagcguungaunnuucacccacuaauagggaacgugngcugggnuuagancgucgugagacagguuaguuuuacccuacugaugnuguguuguugccaugguanuccugcucaguacgagaggaaccgcagnuncanacauuugguguaunugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccggucccccgccgggguccggugcggagugcccuucguccugggaaacggggcgcggccggaaaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<...<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>...<<<<<<<<<<....<<.<<<<........<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>...>>>>..>>..>>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<......>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<<<..<<<<..<.............<<<<.<<<............>>>>>>>........>.....>>>>>>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<<<<<<<<<<<<<<<<<...<<..<<<....<<<<......<<<<<<<<..>>>>>>>>.......>>>>...>>>........>>>>>>..>>>>>>>>>>>....................<<<<<<.<<<<<<<<..........>>>>>>>>.<<<<<<.<<<<.<<<<<<<<<<<.<<<<<.<<<<..<...........>...>>>>.>>>>>.>.>>>>>>>.>>>...>>>>..>>>>.>>..<<<<<<.<<.......>.>>>>>.>>....>>>>>>.....>>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<<<<...<<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<.<......>.>>>>>..<<<<<...<<<..<<<..[[...[[..>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>>.<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<......................<<<.<<<<<<<<<...<<<....<<<..<.<<<<...<<.............>>.>>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<...............................................<........>...........>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<............]]...]]............................>>>>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<...<<<<...<...>...>>>>..>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<...<<<<<<<....>>>>>>>...<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<.<<<<<<<<<<<..<............>.......>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<...............................<...>....<.....<..................>......>...................................................>>>>>>...<<<<<.....<<<<.........<.......>...................<<<<<<<<<<.......>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>><<<<....>>>>>>)))].....<<<<<<<..<<<..)))))).>>>>>>>>>>.........>>>>..>>>>>>.......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<]]].>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.....<<<<<<..<<..<<<<....<<<........<<<<<.<<<<....>>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>..............>>>>..>>.>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<....<<<<<......>>>>>...>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((...((((((((((.....)))))).)))).....)))....(((((((((.....((.((((........((((((((..({((((......)))))....[[(...).(((....}]])))...).)))))))...))).).))...)))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....(((((((((((..(((...(........(....((((.((..............)))))).)......)......))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((..(.((((.......((((((....))))))........))))..))))........))))))..)))))))))))....................((((((..(((((.....(....)...)))))..((((((.((((.(((((((((((.(((((.(((....................))).))))).).))))))).)))...))))..)))).))...(((((.(..........))))).)...[.)))))).....))).)))))...)))))...)))))))).<((((........))))((((((..(.(((((((((((((..(((..(((((........))))..)..)))...((....))...((((((........))))))..(((((...(((..(((..[.......[)))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))..).))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((.(((((((......................(((.((((((((.....((.....((.....(((......(..........)...))).....))...))......))))))...(((((((((.(......))))))))))....))))))))))))..))..((((..(.((.....)).)..))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.....{..............................................................)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((...........]......]]..............(...)........)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((..(((((((...((.....)).))))))....[[(((.((...(.....(((....)))..........(...(((....(...)....)))..).......)....))...(((((........)))))]]((((....(((((...((.((((....)))).))..((((....)))...(...((((((...((((((((((((((((((((((...{{{...)))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....(((((((.......))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).))).))).....((......)).)))).((((.....))))..)))....(((......(.(((...((..(....(.......(((((....(.[..).....)))))((.(((((((((((...(.(.......))........)))))..)))))).))(...).......(((((((((.>.(...........)...(((((((....((((.....))))......))))))).].(.(.(((..((((((.(...(......((.(....).))......).)))))..)))))(.(.(.........).).)........((..........(((((.......)))))..)..)....).)....)).))))))).)..)))...))).)...)))))....)).[..((.((.....>].)).))....(((((..(((.((......((((.(((((...(((((.(((((((((.(((((..............................................................................................................................)))))...(((((.....((((.....................................((((((((((.......))))))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(..((....((....{..))....)).)(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}.....)))..)))))).......(....(.((((.(...((.......))...).))))...)....)........((((.((((((..(.(.(.(((......))).)...).)..((.(.....).))......)))))..)...))).)......((((((....))).)))...a.))..))).))))).....(.((.(.(..(((..(.(((((......(....).....))))).)(((.....((((....((.(((((((}}}.)))))..)).))...))))....))).((((...((((.....}.......))))...))))..)))...).).)).).....((((((...(..((((.(..(((........(((((.((((....)))).))))).......)))...(((...(((....((((.(((((((......)))))))))))...)))...)))...........)..))))..)..))))))(((((....(.......).......((.(((((((.((.....(.((.(..(((((......)))))..))).)....))....)))).))).))..))))).. Structure of the human 80S ribosome at 1.9 A resolution - the molecular role of chemical modifications and ions in RNA; 28S rRNA (3773-MER) 8qoi L7 120 1.9 RF00001 38844527 0003735 0005840 9606 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. Structure of the human 80S ribosome at 1.9 A resolution - the molecular role of chemical modifications and ions in RNA; 5S rRNA (120-MER) 8qoi L8 156 1.9 RF00002,RF02540 38844527 0003735 0005840 9606 cgacucuuagcggnggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauuncaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<<<<....>>>>.....<.<<<......>>.............>>>..>...>>>....<<....>><<<<<<<<<.....>>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))(((((((((.....))))))))).................... Structure of the human 80S ribosome at 1.9 A resolution - the molecular role of chemical modifications and ions in RNA; 5.8S rRNA (156-MER) 8qoi S2 1740 1.9 RF01960,RF02542,RF01959,RF00177 38844527 0003735 0005840 9606 uaccugguugauccugccaguagcaunugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucnuuaaaucaguuauggunccuunggucgcucgcuccucucccacuuggauaacugugguanuucuagngcuaananaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgccccccguggcggcgacgacccauucgaacgucngcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgaunccggaganggagccugagaaacggcuaccacauncaaggnaggcagcaggcgcgcnaauuacccacucccgacccggggangungugangaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaanuccuuuaacgaggnuccauuggagngcaagucuggugccagcagccgcgguaauuccagcuccaauancguauauuaaaguugcugcaguunaaaagcucguaguungaucuugggagcgggcguccccgcccucucggccggggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaaungaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagancgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacncaacacgggaaaccucacccggcncggacacggacagganugacagauugauagcucuuucucgauuccguggguggngnugcauggcnguucuuaguugguggagcgauuugucugguuaauuccgauaacgancgagacunuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuncuuanagggacaaguggcguucagccacccgagauugagcaauaacangucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgagnaauucccaguaagugcgggucauaagcuugcguugauunagucccugcccuuuguacacaccgnccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggucggcccacggcccuggcggagcgcugagaagacggucgaacungacuaucuagaggaaguaaaagucguancaagguuucnguaggugnnccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<....<<....<<<<<..................<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<........>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<<......>>>>>>>>.>>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....<<..<<.<<..<<....>>..>>..>>...>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<.......................<<................>>...<<<<<<.<.......<<...<.......>.<<<<.......>>>>...>>......>.>>>..>>>........<.<<.<<<.<<<...............>>>.>>>.>>.>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<.......<<........>>..........<<<<<.<....<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<.......>>>>.>>>>.....>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.....>.>>>>>....>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>............<<<<<..........>>>>>...........>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<....<.....................>......>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))((...(((((......(..((.....(((.(((..((....(.....((..........))....)[))......(((.......(((.(.(..((....(((.....((.............((.....((.(((.....))).))......))......)).((((...((((........))))...))))((..((.((...(......)..)).))......)).(.((((.((((......)))))))))...)))...))).).))).(((....((.....(((((((.........))))))).))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)........((..((.((..((....))..))..))...))....(.((..(...........)..))......)..((((([[....(.(.((.....((..]])).......)).)))))))..)))))...))..[......(.([....(.(.((...(.(..(.......................((................))...(..(((.(........(..((.......)).(((.......)))....).......).)))....)........(.((.(.(.((.................)).).).)).)....)....(((..(...(...(((...(((.((((((((...(..........)......)))))))).))).......((....))....)))..)...)...))..)).)...)).)....((((((....(...((((.........))))...).))))))......{...(((.((..((..(.((((((.((((......)))))))))).)..))....((...]))...))...].))))).).(((.......(.(....).).....)))...]]].]((((..(((((((..((..((.((..(((..(((((.......(........)...........(((((.(....(((((.....(..((.((..........)).))....).)))))...((.(((...(.((((((....((..((.((....))...(.((......)))...))..))....(((...(...((.(..((((((((((((.......)))).)))).....))))..).))..).....(((((.....)))))........)))....))).))).....).))))).....).)))))...)).)))..))).(...(..(((........(.......(((.((((....)))).)))....).........)))..)......(.....((((............)))).....)..)..)).)).....((((((((.......))))))))......))...))))))).)).))..(.(..((.(..((((.((..(.((((((((.(((..((((.((...((.((....(.(...............)...)......)).))...)).))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}........ Structure of the human 80S ribosome at 1.9 A resolution - the molecular role of chemical modifications and ions in RNA; 18S rRNA (1740-MER) 8qoz 5 79 3.1 RF00020 38778104 0000244,0000353 0005682,0046540 9606 acucugguuucucuucagaucgcauaaaucuuucgccuuuuacuaaagauuuccguggagaggaacaacucugagucuu .<<<...<<<<<<<<<<........<<<<<<<<...........>>>>>>>>...>>>>>>>>>>.......>>>.... ..((...((((((((((...((...((((((((.(.......).)))))))).)))))))))))).......))..... Cryo-EM Structure of Pre-B+5'ss+ATPgammaS Complex (core part); U5 snRNA 8qoz z 11 3.1 38778104 9606 aagguaaguau ........... ........... Cryo-EM Structure of Pre-B+5'ss+ATPgammaS Complex (core part); 5'ss RNA oligo 8qoz 4 80 3.1 RF00015 38778104 0017070 0000244,0000353 0005687,0046540 9606 agcuuugcgcaguggcaguaucguagccaaugaggucuauccgaggcgcgauuauugcuaauugaaaacuuuucccaaua ...................<<<<<.<<<.....<<.....>>..>>>>>>>>............................ ...................(((((.(((.....((.....))..))))))))............................ Cryo-EM Structure of Pre-B+5'ss+ATPgammaS Complex (core part); U4 snRNA 8qoz 6 48 3.1 RF00026 38778104 0030621 0000244,0000353 0005688,0046540 9606 uuggaacgauacagagaagauuagcauggccccugcgcaaggaugaca ................................................ ................................................ Cryo-EM Structure of Pre-B+5'ss+ATPgammaS Complex (core part); U6 snRNA 8qp8 6 37 3.5 RF00026 38778104 0030621 0000244,0000353 0005688,0046540 9606 uuggaaaagauuagcauggccccugcgcaaggaugac ..................................... ..................................... Cryo-EM Structure of Pre-B Complex (core part); U6 snRNA 8qp8 4 76 3.5 RF00015 38778104 0017070 0000244,0000353 0005687,0046540 9606 agcuuugcgcaguggcaguaucguagccaaugaggucuauccgaggcgcgauuugcuaauugaaaacuucccaaua ...................<<<<<.<<<.....<<.....>>..>>>>>>>>........................ ...................(((((.(((.....((.....))..))))))))........................ Cryo-EM Structure of Pre-B Complex (core part); U4 snRNA 8qp9 6 37 4.1 RF00026 38778104 0030621 0000244,0000353 0005688,0046540 9606 uuggaaaagauuagcauggccccugcgcaaggaugac ..................................... ..................................... Cryo-EM Structure of Pre-B+AMPPNP Complex (core part); U6 snRNA 8qp9 4 76 4.1 RF00015 38778104 0017070 0000244,0000353 0005687,0046540 9606 agcuuugcgcaguggcaguaucguagccaaugaggucuauccgaggcgcgauuugcuaauugaaaacuucccaaua ....................<<<..<<......<<.....>>...>>.>>>......................... ...................((((..(((......(.....)...))).))))........................ Cryo-EM Structure of Pre-B+AMPPNP Complex (core part); U4 snRNA 8qpa 5 79 3.7 RF00020 38778104 0000244,0000353 0005682,0046540 9606 acucugguuucucuucagaucgcauaaaucuuucgccuuuuacuaaagauuuccguggagaggaacaacucugagucuu .<<<...<<<<<<<<<<........<<<<<<<<...........>>>>>>>>...>>>>>>>>>>.......>>>.... ..((...((((((((((...((...((((((((.(.......).)))))))).)))))))))))).......))..... Cryo-EM Structure of Pre-B+5'ssLNG Complex (core part); U5 snRNA 8qpa z 18 3.7 38778104 9606 aagguaaguaucguucca .................. .................. Cryo-EM Structure of Pre-B+5'ssLNG Complex (core part); 5'ss oligo 8qpa 4 62 3.7 RF00015 38778104 0017070 0000244,0000353 0005687,0046540 9606 agcuuugcgcaguggcaguaucguagccaaugaggucuauccgaggcgcgauuauugcuaau ...................<<<<<.<<<.....<<.....>>..>>>>>>>>.......... ...................(((((.(((.....((.....))..)))))))).......... Cryo-EM Structure of Pre-B+5'ssLNG Complex (core part); U4 snRNA 8qpa 6 47 3.7 RF00026 38778104 0030621 0000244,0000353 0005688,0046540 9606 uggaacgauacagagaagauuagcauggccccugcgcaaggaugaca ............................................... ............................................... Cryo-EM Structure of Pre-B+5'ssLNG Complex (core part); U6 snRNA 8qpb 5 79 3.7 RF00020 38778104 0000244,0000353 0005682,0046540 9606 acucugguuucucuucagaucgcauaaaucuuucgccuuuuacuaaagauuuccguggagaggaacaacucugagucuu .<<<...<<<<<<<<<<........<<<<<<<<...........>>>>>>>>...>>>>>>>>>>.......>>>.... .(.(....(((((((((...((...((((((((.(.......).)))))))).)))))))))))........).).... Cryo-EM Structure of Pre-B+ATP Complex (core part); U5 snRNA 8qpb 4 80 3.7 RF00015 38778104 0017070 0000244,0000353 0005687,0046540 9606 agcuuugcgcaguggcaguaucguagccaaugaggucuauccgaggcgcgauuauugcuaauugaaaacuuuucccaaua ...................<<<<<.<<<.....<<.....>>..>>>>>>>>............................ ...................(((((.(((.....((.....))..))))))))............................ Cryo-EM Structure of Pre-B+ATP Complex (core part); U4 snRNA 8qpb 6 48 3.7 RF00026 38778104 0030621 0000244,0000353 0005688,0046540 9606 uuggaacgauacagagaagauuagcauggccccugcgcaaggaugaca ................................................ ................................................ Cryo-EM Structure of Pre-B+ATP Complex (core part); U6 snRNA 8qpb z 13 3.7 38778104 9606 aguggguaagagc ............. ............. Cryo-EM Structure of Pre-B+ATP Complex (core part); 5'ss oligo 8qpe 4 63 3.1 RF00015 38778104 0017070 0000244,0000353 0005687,0046540 9606 agcuuugcgcaguggcaguaucguagccaaugaggucuauccgaggcgcgauuauugcuaauu ...................<<<<<.<<<.....<<.....>>..>>>>>>>>........... ...................(((((.(((.....((.....))..))))))))........... Cryo-EM Structure of Pre-B-like Complex (core part); U4 snRNA 8qpe 5 115 3.1 RF00020 URS000075BAAE_9606 38778104 0000244,0000353 0005682,0046540 9606 acucugguuucucuucagaucgcauaaaucuuucgccuuuuacuaaagauuuccguggagaggaacaacucugagucuuaacccaauuuuuugaggccuugcuuuggcaaggcua .<<<..<<<<<<<<<<<........<<<<<<<<...........>>>>>>>>...>>>>>>>>>>>......>>>...................<<<<<<<<....>>>>>>>>. .(((...((((((((((...((...((((((((.(.......).)))))))).)))))))))))).......)))....................((((((......)))))).. Cryo-EM Structure of Pre-B-like Complex (core part); U5 snRNA 8qpe 6 43 3.1 RF00026 38778104 0030621 0000244,0000353 0005688,0046540 9606 acgauacagagaagauuagcauggccccugcgcaaggaugaca ........................................... ........................................... Cryo-EM Structure of Pre-B-like Complex (core part); U6 snRNA 8qpe z1 11 3.1 38778104 9606 aagguaaguau ........... ........... Cryo-EM Structure of Pre-B-like Complex (core part); oligo1 8qpk 5 77 4.2 RF00020 38778104 0000244,0000353 0005682,0046540 9606 acucugguuucucuucagaucgcauaaaucuuucgccuuuuacuaaagauuuccguggagaggaacaacucugaguc ..<<...<<<<<<<<<<........<<<<<<<<...........>>>>>>>>...>>>>>>>>>>.......>>... ..((...(((((((((.....(...((((((((...........)))))))).)..))))))))).......))... Cryo-EM Structure of Pre-B+5'ss Complex (core part); U5 snRNA 8qpk 4 76 4.2 RF00015 38778104 0017070 0000244,0000353 0005687,0046540 9606 agcuuugcgcaguggcaguaucguagccaaugaggucuauccgaggcgcgauuugcuaauugaaaacuucccaaua ....................<<<<.<<......<<.....>>...>>>>>>......................... .....................(((.........(.......).....))).......................... Cryo-EM Structure of Pre-B+5'ss Complex (core part); U4 snRNA 8qpk z 11 4.2 38778104 9606 aagguaaguau ........... ........... Cryo-EM Structure of Pre-B+5'ss Complex (core part); 5'ss oligo 8qpk 6 43 4.2 RF00026 38778104 0030621 0000244,0000353 0005688,0046540 9606 uuggaauacagagaagauuagcauggccccugcgcaaggauga ........................................... ........................................... Cryo-EM Structure of Pre-B+5'ss Complex (core part); U6 snRNA 8qpp U 77 3.4 RF00005 URS00002C7A07_1423 38177497 0030533 0006412 1423 gguccgguaguucaguugguuagaaugccugccugucacgcaggaggucgcggguucgagucccguccggaccgcca <<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.........)))).(((((.......))))).....(((((.......)))))))))))).... Bacillus subtilis MutS2-collided disome complex (stalled 70S); tRNA (77-MER) 8qpp V 33 3.4 38177497 1423 agaccaaugccauguacgucgcacucggaagac ................................. ................................. Bacillus subtilis MutS2-collided disome complex (stalled 70S); mRNA (33-MER) 8qpp Y 112 3.4 RF00001 URS0000BC467F_1423 38177497 0003735 0005840 1423 ugguggcgauagcgaagaggucacacccguucccauaccgaacacggaaguuaagcucuucagcgccgaugguagucggggguuucccccugugagaguaggacgccgccaa <<<<<<<....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<.......<<.<<<<<...>>>>>.>>.......>>..>>>>>>>. (((((((....((((((((.....((((((...(.....)...))))..))....)))))).)).((.......((.(((((...))))).)).......))..))))))). Bacillus subtilis MutS2-collided disome complex (stalled 70S); 5S rRNA (112-MER) 8qpp X 2887 3.4 RF02541 URS00005906D8_1423 38177497 0003735 0005840 1423 guuaaguuagaaagggcgcacgguggaugccuuggcacuaggagccgaugaaggacgggacgaacaccgauaugcuucggggagcuguaagcaagcuuugauccggagauuuccgaauggggaaacccaccacucguaauggagugguauccauaucugaauucauaggauaugagaaggcagacccggggaacugaaacaucuaaguacccggaggaagagaaagcaaaugcgauucccugaguagcggcgagcgaaacgggaucagcccaaaccaagaggcuugccucuugggguuguaggacacucgaacgagguagaugaagaggucuggaaaggcccgccauaggagguaacagcccuguagucaaaacuucguucgaguggauccugaguacggcggaacacgugaaauuccgucggaauccgggaggaccaucucccaaggcuaaauacucccuagugaccgauagugaaccaguaccgugagggaaaggugaaaagcaccccggaaggggagugaaagagauccugaaaccgugugccuacaaguagucagagcccguuaacgggugauggcgugccuuuuguagaaugaaccggcgaguuacgaucucgugcaagguuaagcagaagaugcggagccgcagcgaaagcgagucugaauagggcgcaugaguacguggucguagacccgaaaccaggugaucuacccauguccagggugaaguucagguaacacugaauggaggcccgaacccacgcacguugaaaagugcggggaugagguguggguaggggugaaaugccaaucgaaccuggagauagcugguucucuccgaaauagcuuuagggcuagccucaagguaagagucuuggagguagagcacugauuggacuaggggccccuaccggguuaccgaauucagucaaacuccgaaugccaaugacuuauccuugggagucagacugcgagugauaagauccguagucgaaagggaaacagcccagaccgccagcuaaggucccaaaguauacguuaaguggaaaaggauguggaguugcuuagacaaccaggauguuggcuuagaagcagccaccauuuaaagagugcguaauagcucacuggucgagugacucugcgccgaaaauguaccggggcuaaacguaucaccgaagcugcggacuguucgaacagugguaggagagcguucuaagggcugugaagccagaccggaaggacugguggagcgcuuagaagugagaaugccgguaugaguagcgaaagaggggugagaauccccuccaccgaaugccuaagguuuccugaggaaggcucguccgcucaggguuagucgggaccuaagccgaggccgaaaggcguaggcgauggacaacagguugauauuccuguaccaccuccucaccauuugagcaauggggggacgcaggaggauaggguaagcgcgguauuggauauccgcguccaagcaguuaggcugggaaauaggcaaauccguuucccaaaggcugagcugugauggcgagcgcgaaguuccugauuccacacugccaagaaaagccucuagcgaggugagaggugcccguaccgcaaaccgacacagguaggcgaggagagaauccuaaggugaucgagagaacucucguuaaggaacucggcaaaaugaccccguaacuucgggagaaggggugcucuguuagggugcaagcccgagagagccgcagugaauaggcccaggcgacuguuuagcaaaaacacaggucucugcgaagccguaaggcgaaguauaggggcugacgccugcccggugcuggaagguuaagaggagcgcuuagcguaagcgaaggugcgaauugaagccccaguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgacccgcacgaaaggcgcaacgaucugggcacugucucaacgagagacucggugaaauuauaguaccugugaagaugcagguuacccgcgacaggacggaaagaccccguggagcuuuacugcagccugauauugaauguugguacagcuuguacaggauagguaggagccuuggaaaccggagcgccagcuucgguggaggcaucggugggauacuacccuggcuguauugaccuucuaacccgccgcccuuaucgggcggggagacagugucaggugggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguucccucagaaugguuggaaaucauucgcagaguguaaaggcacaagggagcuugacugcgagaccuacaagucgagcagggacgaaagucgggcuuagugauccggugguuccgcauggaagggccaucgcucaacggauaaaagcuaccccggggauaacaggcuuaucucccccaagaguccacaucgacggggagguuuggcaccucgaugucggcucaucgcauccuggggcuguagucggucccaaggguugggcuguucgcccauuaaagcgguacgcgagcuggguucagaacgucgugagacaguucggucccuauccgucgcgggcgcaggaaauuugagaggagcuguccuuaguacgagaggaccgggauggacgcaccgcugguguaccaguuguucugccaagggcaucgcuggguagcuaugugcggacgggauaagugcugaaagcaucuaagcaugaagccccccucaagaugagauuucccauuccgcaaggaaguaagaucccugaaagaugaucagguugauaggucugagguggaaguguggcgacacauggagcugacagauacuaaucgaucgaggacuuaacc <<.<.<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.....((.>>>.....<<<<<<<..<<<)).....>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<<<<<<<<.........>>>>>>>.>>.>>....<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<......<<.....>>.....>>>>...(((....<<<<<.<<....>>.>>>>>......<<<<<<<..<.<<<<<<<.<<<.....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>...>>>..>>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<....>>>>..................>>>>>>>>>>>.......<<<<..<<<<......>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<.<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>......>>>>>.>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>...>.>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<...<<<<<<<<<.....<<<...<<<<<<<<...<<..<<<.....>>>...>>...>>>>>>>>..>>.>.....>>>>.>>>>>..>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<.....................>>......................>>>>>....>>>>>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<..>>>>>>....>>>>>><.<<<<<<<.<<......<<<<<.<<....>>.>>>>>...>>.>>>>>>>..>.....>>>>>><......<<....<<<<<<.......>>>>>><<<<....<<<<<.<<<..<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<.<<<<<<......<<...<<<<....<<<<..<<<..<<<.<<<<<<<<...(((....>>>>>><<..<<<<<..<<<<<<<<<<<.<<.....>>>>>>>>>...>>>>..>>>>>...>><..<..>...>>>>>>...>>>...>>>>.........>>>>..>>..>>>>>>>>>>>>>>>.>>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<....<<<<....>>>>...>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>..<<<<.<<<..<<<<<<<..<<<...<<...<<<<<<.<<....>>..>>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>...>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<<.<<...<.....<.......................<.........<<..<<....>>..>>......>........................>....>...>>.....<<.<<<<<<.....>>>>>>>>.....>>>>>>>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.)))>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>..>>. ...(..(......((((((((((.....(((..(((((((((((((......((((((.....[[[)))...].((((((...(((]].....)))......))))))...)))....(((....)))(((((((......))))))).(((((((((.........))))))).)).))....((((((.....(...[..)......))))).).........((....))...((((......((.]...)).....))))...((((...(((((.((....)).)))))....{.(((((((....(((((((.(((...(.((((......)))))[[(...).(((.....]])))...)))...)))))))....)))..)))))....((((((((..[......))))))))....}.(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((..((((..[...))))..)))).<.(.(........).).((((((....(((((((.(((((..((....(((.....)))....))...((....))..((((.....))))......))))).)))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)<)))...(((.(((((.......A))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((...(((((((((.....(((...((((((((...((..((.(....)))...))...))))))))..)).).....)))).)))))..))))))).))..(((((((.((......)).)))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(.(((((.((.....{.(((((.(((....(.........)....)))..........(......)....)))))...)).))))).).))...........]]].)...))))))))))...)))))))((((((..))))))....))))))(.(((((...((......(((((.((....))])))))...))...)))))..).....))))))(......((....((((((.......))))))((((....(((...((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((.((((((......((...((((....((((..(((..(((.(((((((((...{{..).))))))((..(((((..(((((((((((.((.....)))))))))...))))..)))))...))(..(..)...))))))...)))...))))(..).....))))..))..))))))))))))))).))).....((......))..))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.[..).....)))))(((((....((((....))))...)))))(...).......(((((((((.>.((.........))...(((((((.....(((....))).......))))))).]((((.(((..(((((((..(((...((...(((((..((....))...)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).[..(((((.....>].)))))..((((((((.(((.((......((((.((((((..(((((.(((((((((.((...(....((((.............(.......((.......(((..((....))..)))....)).................)....))))....)...))....((.((((((.....)))))))).....)))))))))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..a.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..((((....))))....(((.(((((.......)))))....(.((((((.(((....(((((....)))))...)))..))))).).)....)))....).)..... Bacillus subtilis MutS2-collided disome complex (stalled 70S); 23S ribosomal RNA 8qpp A 1533 3.4 RF01959,RF00177,RF02542,RF01960 URS000197CF6E_1423 38177497 0003735 0005840 1423 ggagaguuugauccuggcucaggacgaacgcuggcggcgugccuaauacaugcaagucgagcggacagaugggagcuugcucccugauguuagcggcggacgggugaguaacacguggguaaccugccuguaagacugggauaacuccgggaaaccggggcuaauaccggaugguuguuugaaccgcaugguucaaacauaaaagguggcuucggcuaccacuuacagauggacccgcggcgcauuagcuaguuggugagguaacggcucaccaaggcgacgaugcguagccgaccugagagggugaucggccacacugggacugagacacggcccagacuccuacgggaggcagcaguagggaaucuuccgcaauggacgaaagucugacggagcaacgccgcgugagugaugaagguuuucggaucguaaagcucuguuguuagggaagaacaagugccguucgaauagggcgguaccuugacgguaccuaaccagaaagccacggcuaacuacgugccagcagccgcgguaauacguagguggcaagcguuguccggaauuauugggcguaaagggcucgcaggcgguuucuuaagucugaugugaaagcccccggcucaaccggggagggucauuggaaacuggggaacuugagugcagaagaggagaguggaauuccacguguagcggugaaaugcguagagauguggaggaacaccaguggcgaaggcgacucucuggucuguaacugacgcugaggagcgaaagcguggggagcgaacaggauuagauacccugguaguccacgccguaaacgaugagugcuaaguguuaggggguuuccgccccuuagugcugcagcuaacgcauuaagcacuccgccuggggaguacggucgcaagacugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggucuugacauccucugacaauccuagagauaggacguccccuucgggggcagagugacagguggugcaugguugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuugaucuuaguugccagcauucaguugggcacucuaaggugacugccggugacaaaccggaggaagguggggaugacgucaaaucaucaugccccuuaugaccugggcuacacacgugcuacaauggacagaacaaagggcagcgaaaccgcgagguuaagccaaucccacaaaucuguucucaguucggaucgcagucugcaacucgacugcgugaagcuggaaucgcuaguaaucgcggaucagcaugccgcggugaauacguucccgggccuuguacacaccgcccgucacaccacgagaguuuguaacacccgaagucggugagguaaccuuuuaggagccagccgccgaaggugggacagaugauuggggugaagucguaacaagguagccguaucggaaggugcggcugg ...<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<<.....<........>.......>>>.>>>>>......<<........<<<<<<<..<<...<<<<<<<.<<<<.....<<<<<<....>>>>>>......>>>>.....<<<<<<<<<<....>>>>>>>>>>.....<<<<<<....>>>>>>.>>>>>>>..>>>>>>>>>.<<<....<<<...<<<<<<<.......>>>>>>>.>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<<<<<<<.............<<<<<.....>>>>>..............>>>>>>...>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<.......<<<<<<.....>>>>>>.....>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<......>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<....<<<........>>>....<<<....>>>.>>>>>.>>.<<<..<......<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<......>>>>>...>>>>>>>.....<<<<<.....>>>>>........>>>>.......>.>>>.......>>>.>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<..<<<<....<....<..<<...<<<...>>>..>>>.....>...>>>>..>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.. ...((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((..((....(((.((..)).)))....))..)))))......(((.......(((((((..((...(((((((.((((.....((((((....))))))......))))......((((((.((....)).))))))......((((((....)))))).)))))))..))))))))).(((....(((...(((((((.......))))))).)))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....((((((...(.....(...(((.(.....).)))...).....)....))))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(.(((((.((((((((((......((((((.....))))))...).)))))))..))))))).)..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((......))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((....(((((....)))))....(((....))).))))).)))..(.((......((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..((......)))))...)))))))..(..(((((.....))))).....)..)))).....).).))).......)).)....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((..((((....(.((....((...(((...)))..))...)).)...))))..))))))..))).))))..).))...)..)..(((((((((....)))))))))}. Bacillus subtilis MutS2-collided disome complex (stalled 70S); 16S rRNA (1533-MER) 8qrn A 955 2.98 RF00177 URS0001A24B4C_9606 38969660 0003735 0005840 9606 aauagguuugguccuagccuuucuauuagcucuuaguaagauuacacaugcaagcauccccguuccagugaguucacccucuaaaucaccacgaucaaaagggacaagcaucaagcacgcagcaaugcagcucaaaacgcuuagccuagccacacccccacgggaaacagcagugauuaaccuuuagcaauaaacgaaaguuuaacuaagcuauacuaaccccaggguuggucaauuucgugccagccaccgcggucacacgauuaacccaagucaauagaagccggcguaaagaguguuuuagaucacccccuccccaauaaagcuaaaacucaccugaguuguaaaaaacuccaguugacacaaaauagacuacgaaaguggcuuuaacauaucugaacacacaauagcuaagacccaaacuggganuagauaccccacuaugcuuagcccuaaaccucaacaguuaaaucaacaaaacugcucgccagaacacuacgagccacagcuuaaaacucaaaggaccuggcggugcuucauaucccucuagaggagccuguucuguaaucgauaaaccccgaucaaccucaccaccucuugcucagccuauauaccgccaucuucagcaaacccugaugaaggcuacaaaguaagcgcaaguacccacguaaagacguuaggucaagguguagcccaugagguggcaagaaaugggcuacauuuucuaccccagaaaacuacgauagcccuuaugaaacuuaagggucgaagguggauuuagcaguaaacugagaguagagugcuuaguugaacagggcccugaagcgcguacacaccgncngucacccuccucaaguauacuucaaaggacauuuaacuaaaaccccuacgcauuuauauagaggagacaagucguaacaugguaaguguacuggnnagugcacuuggacgaacc ...((((..<<<<<<.)))).<<<<<<.<...<<<<<<<<..<.<<<.<<<..<......>......<<.......<<<<.<..<<.......>>.>..>>>>..<<<<....<<...<<<....>>>..>>......>>>>.<<...>>.>>.<<......>>.....>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>.....<<<<<<<<.....(((.....((.>>>)).......)))..>>>>>...>.>>>>>>....<<<((.....<<<<..<<<<...............<<<<<<......<<<.<<<.<<<......>>>..>>>.>>>.............<<....>>.>>>>>>.....>>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<.<<<<<......))..>>>>>.>.>>>.<<.......<<<<....>>>>.....>>..>>>>>><<<<<.<<<<<<<...<<<.<<<<<..<<<<<<<<<<.....<<........>>..........<<<<<<<.......<<.<<<..<<<<<<.......<<..<<<<<.....>>>.......>>..>>.....<<<....>>>.........>>>...>>>>>>>>....>>>>>>>..>>.>>>>>>>>.....<<<<.....>>>>.....<....<<<<<<<.......>>>>>>>....>.....>>>>>.....<<<<<<<.........>>>>>>>.....>>>...>>>>>>>>>>.>>....<..<<.<...<<<<<<..<<<<<......<<<...<<<.....>>>..>>>.......>>>>>.>>>>>>....>.>>...>.....<<<<<<<<<....>>>>>>>>>......... .[.[[[[..(((((..]]]]]((((((.((..((((((((..(.(((.(((..(......)......(((......((((.(..(((.....))).)..))))..((((....((..((((....))).)))......)))).((...))))).(((....))).....)))))))......(.(((...(((((....)))).))))).)).)))))).....((((([[[.....(((.....((.]]])).......)))..)))))..)).))))))....((([[...(.((((...(((...............(((((((.....(((.(((.((........))..))).))).....).....(.((....))))))))).....)))....))))....((((((...((...((((.........))))...))))))))......{...(.(((((......]]..))))).))))).((.......((((....)))).....))...)))))(((((.((((((.....((.(((((..((((((((((.....((........))..........(((((((.......((.(((...((((((.(....((..(((((.....))).......))..)).....(((....))).....).).)))...)).)))))....)))))))..)).)))))))).(...((((.....)))).....(....(((((((.......)))))))....)..)..))))).....(((((((.........))))))).....)).....))))))))).))..(.(..((.(...((((((..(((((..((..(((....((.....))...)))..).)..))))).))))))....).))...)..)..(((((((((....)))))))))}........ mt-SSU in GTPBP8 knock-out cells, state 4; 12S mitochondrial rRNA 8qrn 5 71 2.98 URS0000D77905_9606 38969660 9606 aguaaggucagcuaaauaagcuaucgggccnauaccccgaaaauguugguuauacccuucccguacuacca <<<<.<<..<<<<.....>>>>.<<<<<.......>>>>>.......<<......>>...>>.>>>>.... ((((.((..((((.....)))).(((((.......))))).......((......))...)).)))).... mt-SSU in GTPBP8 knock-out cells, state 4; fMet-tRNAMet 8qxd 2 97 9.6 RF00004 38778104 0045131 0000348 0005686 9606 cgcuucucggcaaguguaguaucuguucuuaucaguuuaauaucugauagauuuuuggagcaucgaccugguauugcaguaccuccaggaacggugc ...............................<<<<.<....>.>>>>............<<<<<<.<<<<<.............>>>>>..>>>>>> ...............................((((........))))............((((((.(((((.............)))))..)))))) Cryo-EM structure of the cross-exon pre-B complex; U2 snRNA 8qxd 4 124 9.6 RF00015 38778104 0017070 0000244,0000353 0005687,0046540 9606 agcuuugcgcaguggcaguaucguagccaaugaggucuauccgaggcgcgauuugcuaauugaaaacuucccaauagccgugacgacuagucggcacuggcaauuuuugacagucucgagacug ...................<<<<<.<<<.....<<.....>>..>>>>>>>>........................<<<<<<.<<<<..>>>>.>>>.>>>.........<<<<<<<>>>>>>> ...................(((((.(((.....((.....))..))))))))........................(((.((.((((())))).))..))).........((((((())))))) Cryo-EM structure of the cross-exon pre-B complex; U4 snRNA 8qxd 6 53 9.6 RF00026 URS000035C796_9606 38778104 0030621 0000244,0000353 0005688,0046540 9606 uuggaaaagauuagcauggccccugcgcaaggaugacuucgugaagcgauuuu ..................................................... ..................................................... Cryo-EM structure of the cross-exon pre-B complex; U6 snRNA 8qxd Z 15 9.6 38778104 9606 gaugucauacuuauc ............... ............... Cryo-EM structure of the cross-exon pre-B complex; pre-mRNA 8qyx A2 3706 1.78 RF02540,RF02543,RF02541 39658079 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagngngaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcggcccggcggaucuuucccgcgcgggggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucgggggcccccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcgcucuccccccucccggcgggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccgggggaggccacgcgcgcgucccccgaagagggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccnucuugnnacncggaccaaggagunuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccnanagauggugancuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauagnggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcagacccgacgcccgccacgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccanuuuugguaagcngaacuggcgnugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagcggcggccggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaunuuggugguagunnnaaauauucaaacgagaacuuugaaggccgaaguggngaaggguuccaugngaacagnanuugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccnuauccgcagcaggucuncaaggugaacngccucuggnauguuggaacaanguagguaagggaagucggcaagcnggauccguaacuucnggauaaggauuggcucuaagggcugggucggucgcggccggcgccuagcagccgacuuagaacuggugcggaccaggngaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccncggcggguguugacgcgaugugauuucugccnagugcucugaaugucanagugaagaaauucaaugaagcgcggnuaaacggcgggaguaacuaugacucucuuaagguagcnaanugccucnucaucuaauuagugangcgcaugaanggaugancgagnuucccacugunccuaccuacuauccagcgaaaccacngncaagggaacgggcuuggnggaaucagcggngaaagaagacccuguugagcuugacncuagucuggcacggugaagagacaugagagguguagaauaagugggaggccccgccggugaaauaccacuacucugaucguuuuuucacugacccggugaggcgggggggcgagccccgaggggcucucgcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacugnggcgguacaccugucaaacgguancgcaggnnuccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucagnacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggangugucagaaaaguuaccacagngauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuungaugucggnucuuccuaucauugugaagcagaauucaccaagcguungaunnuucacccacuaauagggaacgugngcugggnuuagancgucgugagacagguuaguuuuacccuacugaugnuguguuguugccaugguaauccugcucaguacgagaggaaccgcagnuncanacauuugguguaunugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccggucccccgccgggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<<...<<<<<<<<<<<...>>>>>>>.>>>>.....>>>>>..<<<<<<<<<<...<<<<<...<<<<....<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>>>>>..>>>>>..>>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<<<..<<<<<<<..<....<<....<<<<.<<<...<<....>>.>>>>>>>>>...>..>>>>...>>>>>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<<<<<<<<<<<<<<<<<...<<..<<<.<..<<<<......<<<<<<<<..>>>>>>>>.......>>>>.>.>>>........>>>>>>..>>>>>>>>>>>....................<<<<<<.<<<<<<<......>>>>>>>.<<<<<<.<<<<.<<<<<<<<<<<<<<<<<<<<<<<.<...........>..>>>>>>>>>>>.>>>>>>>>>.>>>...>>>>..>>>>.>>..<<<<<<<...........>>>>>.>>....>>>>>>.....>>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<<<<...<<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<......>>>>>>>..<<<<<...<<<..<<<..(((...(((>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>>.<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<......................<<<.<<<<<<<<<...<<<....<<<..<.<<<..<..<.............>..>>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.........>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<..........<..<<.....................>>........................>.....>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<..........)))...)))...........................>>>>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<...........>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<..<<<<<<<......>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<...<..........>........>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<...............>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<<<......<...........................................>....>..>>>.>>>>>...<<<<<.....<<<<.....................................<<<<<<<<<<.......>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>><<<<....>>>>>>)))].....<<<<<<<..<<<..)))))).>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<....<<<<<.................>>>>>..<<<<....<<<<....<<.<<<<<<<]]].>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.....<<<<<<<.<<..<<<<....<<<........<<<<<.<<<.<...>>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>..............>>>>..>>>>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<.<..<<<<<......>>>>>..>>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..(((((((((((.....)))))).))))....))))....(((...((((...(((.((..((((....((((((((..({((((......)))))....[[(...).(((....}]])))...).))))))))))).)).)))..))))...)))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((.......((((.((......(((((((((((..(((((((..(....((....((((.(((............)))))))))...)..))))...)))))))))))))).......)).))).).......(((((((((((((((((((((((...((..(((....((((......(.(((((....))))).).......))))...)))........))))))..)))))))))))....................((((((.(((((((......))))))).((((((.((((.((((((((((.(((((..((((..................))))..)))).).))))))).)))...))))..)))).))..((((.(.((.......).)).)).))..[.)))))).....))).)))))...)))))...)))))))).<((((........))))((((((....(((((((((((((..(((..(((((........))))..)..)))...((....))...(((((.(......).)))))..(((((...(((..(((..[.[...[[[)))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((......................(((.((((((((.....((.....((.....((.....(.............)...)).....))...))......))))))...(((((((((.(......))))))))))....))))))))))))..))..((((..(.((.....)).)..))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.....{.....(.................................(............)..)......)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((..........]]]...].]].............(...)........)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((..(((((((...((.....)).))))))....[[(((.((...(.....(((....)))...(.)....((.(((((...(...)...))))))).......)....))...(((((........)))))]]((((....(((((...((((((......))))))..((((....)))...(...((((((...((((((((((((((((((((((...{{{...)))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....(((((((.......))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).))).))).....((......)).)))).((((.....))))..)))....((((.....(.((((..((..(....(.......(((((....(.[..).....)))))((.(((((((((((...(.(.......))........)))))..)))))).))(...).......(((((((((.>.(...........)...(((((((....((((.....))))......))))))).].(.(.(((..((((((.....(......((((....))))......)..))))..)))))(((.............)))........((..........(((((.......)))))..)..)....).)....)).))))))).)..)))..)))).)..))))))....)).[..((.((.....>].)).))....(((((..(((.((......((((.(((((...(((((.(((((((((.((((..((.(........................................................)))...))))...(((((.....((((.....................................((((((((((.......))))))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(..((....((....{..))....)).)(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}.....)))..)))))).......(....(.((((.(...((.......))...).))))...)....)........((((.((((((..(.(.(.(((......))).)...).)..((.(.....).))......)))))..)...))).)......((((((....))).)))...a.))..))).))))).....(.((.(.(..(((..(.(((((......(....).....))))).)(((.....((((....((.(((((((}}}.)))))..)).))...))))....))).((((...((((.....}.......))))...))))..)))...).).)).).....(((((((.((..((((.(..(((........(((((.(((.(...)))).))))).......)))...(((..((((....((((.(((((((......)))))))))))...))))..)))...........)..))))..)))))))))(((((....(.......).......((.(((((((.((.....((((.(..(((((......)))))..)))))....))....)))).))).))..))))).. Human 60S ribosomal subunit; 28S rRNA 8qyx B2 119 1.78 RF00001 39658079 0003735 0005840 9606 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))). Human 60S ribosomal subunit; 5S rRNA 8qyx C2 156 1.78 RF00002,RF02540 39658079 0003735 0005840 9606 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauuncaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<<<<....>>>>.....<.<<<......>>.............>>>..>...>>>....<<....>><<<<<<<<<.....>>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))((((((((.......)))))))).................... Human 60S ribosomal subunit; 5.8S rRNA 8qz8 V 33 3.13 URS00029156D5_1549864 38066000 1549864 aaaucuuucuccugauuugugaguaaaauuugg <<...>>.......................... ((...)).......................... Tilapia Lake Virus polymerase in vRNA pre-termination state (transcriptase conformation); Template vRNA_S loop (40-mer) 8qzs 5 109 4.1 RF00020 38778104 0000244,0000353 0005682,0046540 9606 acucugguuucucuucagaucgcauaaaucuuucgccuuuuacuaaagauuuccguggagaggaacaacucugaguccaauuuuuugaggccuugcuuuggcaaggcua .<<<..<<<<<<<<<<<........<<<<<<<<...........>>>>>>>>...>>>>>>>>>>>......>>>.............<<<<<<<<....>>>>>>>>. .(((...((((((((((...((...((((((((.(.......).)))))))).)))))))))))).......))).............((((((((....)))))))). Cryo-EM structure of the cross-exon B-like complex; U5 snRNA 8qzs 2 98 4.1 RF00004 URS0000E60B66_9606 38778104 0045131 0000348 0005686 9606 cgcuucucggccaaguguaguaucuguucuuaucaguuuaauaucugauagauuuuuggagcaucgaccugguauugcaguaccuccaggaacggugc ...............................<<<<<.<....>.>>>>>...........<<<<<<.<<<<<.............>>>>>..>>>>>> ...............................(((((........)))))...........((((((.(((((.............)))))..)))))) Cryo-EM structure of the cross-exon B-like complex; U2 snRNA 8qzs 6 59 4.1 RF00026 38778104 0030621 0000244,0000353 0005688,0046540 9606 acgauacagagaagauuagcauggccccugcgcaaggaugacauucgugaagcguauuu ........................................................... ........................................................... Cryo-EM structure of the cross-exon B-like complex; U6 snRNA 8qzs 4 136 4.1 RF00015 URS00003F07BD_9606 38778104 0017070 0000244,0000353 0005687,0046540 9606 agcuuugcgcaguggcaguaucguagccaaugaggucuauccgaggcgcgauuauugcuaauuacuuuucccaauaccccgccgugacgacuugcaauauagucggcacuggcaauuuuugacagucucgagacug ...................<<<<<.<<<.....<<.....>>..>>>>>>>>............................<<<<<<.<<<<<........>>>>>.>>>.>>>.........<<<<<<..>>>>>> ...................(((((.(((.....((.....))..))))))))............................(.((((.(((((........))))).))).).)..........(((((()))))). Cryo-EM structure of the cross-exon B-like complex; U4 snRNA 8qzs Z 15 4.1 38778104 9606 gaugucauacuuauc ............... ............... Cryo-EM structure of the cross-exon B-like complex; Pre-mRNA 8qzs z1 11 4.1 38778104 9606 aagguaaguau ........... ........... Cryo-EM structure of the cross-exon B-like complex; Oligo 1 8r08 Z 15 6.1 38778104 9606 gaugucauacuuauc ............... ............... Cryo-EM structure of the cross-exon pre-B+AMPPNP complex; pre-mRNA 8r08 2 97 6.1 RF00004 38778104 0045131 0000348 0005686 9606 cgcuucucggcaaguguaguaucuguucuuaucaguuuaauaucugauggauuuuuggagcaucgaccugguauugcaguaccuccaggaacggugc ...............................<<<<.<....>.>>>>............<<<<<<.<<<<<.............>>>>>..>>>>>> ...............................((((........))))............((((((.(((((.............)))))..)))))) Cryo-EM structure of the cross-exon pre-B+AMPPNP complex; U2 snRNA 8r08 4 124 6.1 RF00015 38778104 0017070 0000244,0000353 0005687,0046540 9606 agcuuugcgcaguggcaguaucguagccaaugaggucuauccgaggcgcgauuugcuaauugaaaacuucccaauagccgugacgacuagucggcacuggcaauuuuugacagucucgagacug ....................<<<..<<.......<.....>....>>.>>>.........................<<<<<<.<<<<..>>>>.>>>.>>>.........<<<<<<<>>>>>>> ...................((((..(((.....((.....))..))).))))........................(((..(.((((()))).))...))).........((((((())))))) Cryo-EM structure of the cross-exon pre-B+AMPPNP complex; U4 snRNA 8r08 6 53 6.1 RF00026 URS000035C796_9606 38778104 0030621 0000244,0000353 0005688,0046540 9606 uuggaaaagauuagcauggccccugcgcaaggaugacuucgugaagcgauuuu ..................................................... ..................................................... Cryo-EM structure of the cross-exon pre-B+AMPPNP complex; U6 snRNA 8r09 Z 15 4.3 38778104 9606 gaugucauacuuauc ............... ............... Cryo-EM structure of the cross-exon pre-B+5'ss+ATPgammaS complex; pre-mRNA 8r09 2 98 4.3 RF00004 38778104 0045131 0000348 0005686 9606 cgcuucucggccaaguguaguaucuguucuuaucaguuuaauaucugauggauuuuuggagcaucgaccugguauugcaguaccuccaggaacggugc ................................<<<<.<....>.>>>>............<<<<<<.<<<<<.............>>>>>..>>>>>> ................................((((........))))............((((((.(((((.............)))))..)))))) Cryo-EM structure of the cross-exon pre-B+5'ss+ATPgammaS complex; U2 snRNA 8r09 5 112 4.3 RF00020 38778104 0000244,0000353 0005682,0046540 9606 acucugguuucucuucagaucgcauaaaucuuucgccuuuuacuaaagauuuccguggagaggaacaacucugagucuuccaauuuuuugaggccuugcuuuggcaaggcua .<<<...<<<<<<<<<<........<<<<<<<<...........>>>>>>>>...>>>>>>>>>>.......>>>................<<<<<<<<....>>>>>>>>. ..((...((((((((((...((...((((((((.(.......).)))))))).)))))))))))).......)).................((((((((....)))))))). Cryo-EM structure of the cross-exon pre-B+5'ss+ATPgammaS complex; U5 snRNA 8r09 z 11 4.3 38778104 9606 aagguaaguau ........... ........... Cryo-EM structure of the cross-exon pre-B+5'ss+ATPgammaS complex; 5'ss oligo 8r09 4 128 4.3 RF00015 38778104 0017070 0000244,0000353 0005687,0046540 9606 agcuuugcgcaguggcaguaucguagccaaugaggucuauccgaggcgcgauuauugcuaauugaaaacuuuucccaauagccgugacgacuagucggcacuggcaauuuuugacagucucgagacug ...................<<<<<.<<<.....<<.....>>..>>>>>>>>............................<<<<<<.<<<<..>>>>.>>>.>>>.........<<<<<<<>>>>>>> ...................(((((.(((.....((.....))..))))))))............................((((((.((((())))).))).))).........((((((())))))) Cryo-EM structure of the cross-exon pre-B+5'ss+ATPgammaS complex; U4 snRNA 8r09 6 65 4.3 RF00026 38778104 0030621 0000244,0000353 0005688,0046540 9606 uuggaacgauacagagaagauuagcauggccccugcgcaaggaugacauucgugaagcguauuuu ................................................................. ................................................................. Cryo-EM structure of the cross-exon pre-B+5'ss+ATPgammaS complex; U6 snRNA 8r0a 5 115 5.8 RF00020 URS000075BAAE_9606 38778104 0000244,0000353 0005682,0046540 9606 acucugguuucucuucagaucgcauaaaucuuucgccuuuuacuaaagauuuccguggagaggaacaacucugagucuuaacccaauuuuuugaggccuugcuuuggcaaggcua ..<<...<<<<<<<<<<........<<<<<<<<...........>>>>>>>>...>>>>>>>>>>.......>>....................<<<<<<<<....>>>>>>>>. ..((...(((((((((.....(...((((((((...........)))))))).)..))))))))).......)).....................(((((((....))))))).. Cryo-EM structure of the cross-exon pre-B+5'ss complex; U5 snRNA 8r0a Z 15 5.8 38778104 9606 gaugucauacuuauc ............... ............... Cryo-EM structure of the cross-exon pre-B+5'ss complex; pre-mRNA 8r0a z 11 5.8 38778104 9606 aagguaaguau ........... ........... Cryo-EM structure of the cross-exon pre-B+5'ss complex; 5'ss oligo 8r0a 2 97 5.8 RF00004 38778104 0045131 0000348 0005686 9606 cgcuucucggcaaguguaguaucuguucuuaucaguuuaauaucugauggauuuuuggagcaucgaccugguauugcaguaccuccaggaacggugc ..............................<<<<<.<....>.>>>>>...........<<<<<<.<<<<<.............>>>>>..>>>>>> ..............................(((((........)))))...........((((((.(((((.............)))))..)))))) Cryo-EM structure of the cross-exon pre-B+5'ss complex; U2 snRNA 8r0a 4 124 5.8 RF00015 38778104 0017070 0000244,0000353 0005687,0046540 9606 agcuuugcgcaguggcaguaucguagccaaugaggucuauccgaggcgcgauuugcuaauugaaaacuucccaauagccgugacgacuagucggcacuggcaauuuuugacagucucgagacug ....................<<<<.<<..................>>>>>>.........................<<<<<<.<<<<..>>>>.>>>.>>>.........<<<<<<<>>>>>>> .....................(((.........(.......).....)))..........................(((.((.((((())))).))..))).........((((((())))))) Cryo-EM structure of the cross-exon pre-B+5'ss complex; U4 snRNA 8r0a 6 59 5.8 RF00026 38778104 0030621 0000244,0000353 0005688,0046540 9606 uuggaauacagagaagauuagcauggccccugcgcaaggaugauucgugaagcgauuuu ........................................................... ........................................................... Cryo-EM structure of the cross-exon pre-B+5'ss complex; U6 snRNA 8r0b 2 98 4.4 RF00004 38778104 0045131 0000348 0005686 9606 cgcuucucggccaaguguaguaucuguucuuaucaguuuaauaucugauggauuuuuggagcaucgaccugguauugcaguaccuccaggaacggugc ...............................<<<<<.<....>.>>>>>...........<<<<<<.<<<<<.............>>>>>..>>>>>> ...............................(((((........)))))...........((((((.(((((.............)))))..)))))) Cryo-EM structure of the cross-exon pre-B+ATP complex; U2 snRNA 8r0b 4 128 4.4 RF00015 38778104 0017070 0000244,0000353 0005687,0046540 9606 agcuuugcgcaguggcaguaucguagccaaugaggucuauccgaggcgcgauuauugcuaauugaaaacuuuucccaauagccgugacgacuagucggcacuggcaauuuuugacagucucgagacug ...................<<<<<.<<<.....<<.....>>..>>>>>>>>............................<<<<<<.<<<<..>>>>.>>>.>>>.........<<<<<<<>>>>>>> ...................(((((.(((.....((.....))..))))))))............................(((.((.((((())))).))..))).........((((((())))))) Cryo-EM structure of the cross-exon pre-B+ATP complex; U4 snRNA 8r0b 5 112 4.4 RF00020 38778104 0000244,0000353 0005682,0046540 9606 acucugguuucucuucagaucgcauaaaucuuucgccuuuuacuaaagauuuccguggagaggaacaacucugagucuuccaauuuuuugaggccuugcuuuggcaaggcua .<<<...<<<<<<<<<<........<<<<<<<<...........>>>>>>>>...>>>>>>>>>>.......>>>................<<<<<<<<....>>>>>>>>. .(.(....(((((((((...((...((((((((.(.......).)))))))).)))))))))))........).)................((((((((....)))))))). Cryo-EM structure of the cross-exon pre-B+ATP complex; U5 snRNA 8r0b 6 65 4.4 RF00026 38778104 0030621 0000244,0000353 0005688,0046540 9606 uuggaacgauacagagaagauuagcauggccccugcgcaaggaugacauucgugaagcguauuuu ................................................................. ................................................................. Cryo-EM structure of the cross-exon pre-B+ATP complex; U6 snRNA 8r0b Z 15 4.4 38778104 9606 gaugucauacuuauc ............... ............... Cryo-EM structure of the cross-exon pre-B+ATP complex; pre-mRNA 8r0b z 13 4.4 38778104 9606 aguggguaagagc ............. ............. Cryo-EM structure of the cross-exon pre-B+ATP complex; 5'ss oligo 8r3k V 31 3.43 38316757 1318616 aguagaaacaaggguguauuuuccccucuuu .<<....>>...................... .((....))...................... Influenza A/H7N9 polymerase in self-stalled pre-termination state, with Pol II pS5 CTD peptide mimic bound in site 1A/2A.; 51-mer vRNA loop (v51_mut_S) 8r3k M 10 3.43 38316757 1318616 ggggaaaaua .......... .......... Influenza A/H7N9 polymerase in self-stalled pre-termination state, with Pol II pS5 CTD peptide mimic bound in site 1A/2A.; RNA product 8r3l R 15 3.25 38316757 1318616 uccccugcuuuugcu ............... ............... Influenza A/H7N9 polymerase in pre-initiation state, intermediate conformation (I) with PB2-C(I), ENDO(T), and Pol II pS5 CTD peptide mimic bound in site 1A/2A; 3' vRNA end (51-mer vRNA loop) 8r3l V 16 3.25 38316757 1318616 aguagaaacaagggug .<<....>>....... .((....))....... Influenza A/H7N9 polymerase in pre-initiation state, intermediate conformation (I) with PB2-C(I), ENDO(T), and Pol II pS5 CTD peptide mimic bound in site 1A/2A; 3' vRNA end (51-mer vRNA loop) 8r3v 71 30 3.28 RF02541 38409277 0003735 0005840 562 acggcggccguaacnauaacgguccuaagg .....<<<<<<.......>>>>>>...... .....(((((.........)))))...... Escherichia coli paused disome complex (non-rotated disome interface); 23S ribosomal RNA 8r3v 72 2904 3.28 RF02541 38409277 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaucuu <<<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<<.....>>>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<..<<....>>..>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<..<<....>>...>>>>>..>....>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<<<<<............<...<<<....>>>...>...................>>>>>...>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>.. (.((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((((((.....))))).))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((.((....)).))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.(((..(.........(((((............((..(((....)))..))...................))))))..))).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))).).. Escherichia coli paused disome complex (non-rotated disome interface); 23S ribosomal RNA 8r3v 82 120 3.28 RF00001 38409277 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Escherichia coli paused disome complex (non-rotated disome interface); 5S ribosomal RNA 8r3v A1 1542 3.28 RF00177,RF01959,RF02542,RF01960 38409277 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggaucaccuccuua ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<......>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<......>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>..<<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>>.<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<.....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>..>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<.<<<<.....>>>>.>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<.<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>..<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.......<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>........<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<..<<<<<....<<<<...<<<...<<....>>.>.>>..>>>>...>>>>>..>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.............. ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((((....))))))).)))))..)))))......(((.......((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....))).....(((((..........)))))..)))))))..)).)))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..(((.......((((....))))......)))..((.(((((...(....(((.((((.......)))).))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.((((((..((((((((((......((((((.....))))))....))))))))..)).))))))..(((((((((...((((((.(....(((((((...((........))......)))))))....).......((....))..))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((.(((.....))).))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((.((((((..((((((((((......((........))..........(((((((..(.....(((((..(((((((....))))))).............)))))...).((.(((...((.(((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((.(...((..((.......))))....).)))))..(..(((((.....))))).....)..)))).....).).))....)).)))))....)))))))...)).)))))))).(...(.((((......(((..((...(((....)))...))....)))......)))).)......(....(((((((........)))))))....)..)..))))))....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((.((((((....(((....((.(..((....)).).))...)))...))))).))))))..))).))))..).))...)..)..(((((((((....)))))))))}............. Escherichia coli paused disome complex (non-rotated disome interface); 16S ribosomal RNA 8r3v A2 1537 3.28 RF00177,RF01959,RF02542,RF01960 38409277 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggaucaccu ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<......>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..........>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<.<<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<.......<<<....>>>......>>>>.....<<<<<........<<<.<<<<.......>>>>.>>>..........>>>>>.......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<..<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>.........>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<..<.<<<<<<<........>>>>>>>>...>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<...<<....>>..>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(...(((.(((((......)))))..))).)..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....))).....(((((..(......))))))..)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((.....(((....)))...)))).)).))))))..((((.......(((....)))......))))..(..(((((...(....((..((((.......))))..)).....)....))))).....).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(.(((((...((.(((....))).))....((....))..)))))..)).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((.(.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..).)).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(.(((((.........))))).)......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........ Escherichia coli paused disome complex (non-rotated disome interface); 16S ribosomal RNA 8r3v V2 64 3.28 38409277 562 aaaaaggacggugagcuucgugacaauuaaaaaaaagguuucgcgcugggccaaaaucgaaaaa ................................................................ ................................................................ Escherichia coli paused disome complex (non-rotated disome interface); messenger RNA 8r3v W 76 3.28 RF00005 38409277 0030533 562 aggggcgnaguucaannggnagagcaccgguuuccanaaccgggunuugggagnucgagucucuccgccccugcca <<<<<<<..<<<<........>>>><<<<<<<.....>>>>>>.>...<<<<<.......>>>>>>>>>>>>.... (((((((..(.((.....[..)).).(((((.......))))).....(.(((..]....))).)))))))).... Escherichia coli paused disome complex (non-rotated disome interface); tRNA-Trp (P-site) 8r3v W1 36 3.28 38409277 562 nagcucagagagcaggggauugaanauccccgunuc ..<<<<...>>>>.<<<<<<.....>>>>>>..... ..((((...)))).((((.........))))..... Escherichia coli paused disome complex (non-rotated disome interface); tRNA-Phe (P-site) 8r3v X2 77 3.28 RF00005 38409277 0030533 562 gcauccgnagcucagcngganagaguacucggnuicgnaccgagcgnncggaggnucgaauccucccggaugcacca <<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.........)))).(((((.......))))).....(((((.......)))))))))))).... Escherichia coli paused disome complex (non-rotated disome interface); tRNA-Arg (E-site) 8r3v Y1 36 3.28 38409277 562 uagcucagagagcaccucccunacnaggaggggnuc ..<<<<...>>>>.<<<<<.......>>>>>..... ..((((...)))).((((.........))))..... Escherichia coli paused disome complex (non-rotated disome interface); tRNA-Val (A-site) 8r3v Y2 76 3.28 38409277 562 ggggcuauagcucagcngggagagcgcuugcauggcaugcaagagnucagcggnucgaucccgcuuagcuccacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).(((((.......))))).....(((((..]....)))))))))))).... Escherichia coli paused disome complex (non-rotated disome interface); tRNA-Ala (A-site) 8r55 7 73 3.57 RF00005 URS00023358F7_1423 38177497 0030533 0006412 1423 gcgcggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgcgca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>. (((((((..((((........)))).(((((.......))))).....((.((.......)).))))))))). Bacillus subtilis MutS2-collided disome complex (collided 70S); tRNA (73-MER) 8r55 A 1533 3.57 RF01959,RF00177,RF02542,RF01960 URS000197CF6E_1423 38177497 0003735 0005840 1423 ggagaguuugauccuggcucaggacgaacgcuggcggcgugccuaauacaugcaagucgagcggacagaugggagcuugcucccugauguuagcggcggacgggugaguaacacguggguaaccugccuguaagacugggauaacuccgggaaaccggggcuaauaccggaugguuguuugaaccgcaugguucaaacauaaaagguggcuucggcuaccacuuacagauggacccgcggcgcauuagcuaguuggugagguaacggcucaccaaggcgacgaugcguagccgaccugagagggugaucggccacacugggacugagacacggcccagacuccuacgggaggcagcaguagggaaucuuccgcaauggacgaaagucugacggagcaacgccgcgugagugaugaagguuuucggaucguaaagcucuguuguuagggaagaacaagugccguucgaauagggcgguaccuugacgguaccuaaccagaaagccacggcuaacuacgugccagcagccgcgguaauacguagguggcaagcguuguccggaauuauugggcguaaagggcucgcaggcgguuucuuaagucugaugugaaagcccccggcucaaccggggagggucauuggaaacuggggaacuugagugcagaagaggagaguggaauuccacguguagcggugaaaugcguagagauguggaggaacaccaguggcgaaggcgacucucuggucuguaacugacgcugaggagcgaaagcguggggagcgaacaggauuagauacccugguaguccacgccguaaacgaugagugcuaaguguuaggggguuuccgccccuuagugcugcagcuaacgcauuaagcacuccgccuggggaguacggucgcaagacugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggucuugacauccucugacaauccuagagauaggacguccccuucgggggcagagugacagguggugcaugguugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuugaucuuaguugccagcauucaguugggcacucuaaggugacugccggugacaaaccggaggaagguggggaugacgucaaaucaucaugccccuuaugaccugggcuacacacgugcuacaauggacagaacaaagggcagcgaaaccgcgagguuaagccaaucccacaaaucuguucucaguucggaucgcagucugcaacucgacugcgugaagcuggaaucgcuaguaaucgcggaucagcaugccgcggugaauacguucccgggccuuguacacaccgcccgucacaccacgagaguuuguaacacccgaagucggugagguaaccuuuuaggagccagccgccgaaggugggacagaugauuggggugaagucguaacaagguagccguaucggaaggugcggcugg ...<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<<<....<..........>....>>>>.>>>>>......<<........<<<<<<<..<<...<<<<<<<.<<<<.....<<<<<<....>>>>>>......>>>>.....<<<<<<.<<<....>>>.>>>>>>.....<<<<<<....>>>>>>.>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<<<<<<<.........<<<<<<<<.......>>>>>>>>..........>>>>>>...>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<.......<<<<<<.....>>>>>>.....>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<<....>>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<....<<<........>>>....<<<....>>>.>>>>>.>>.<<<.<.......<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<......>>>>>...>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>.......>>>.>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<..<<<<....<....<..<<...<<.....>>..>>>.....>...>>>>..>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.. ...((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((....((..((..))..))....))).)))))......(((.......(((((((..((...(((((((.((((.....((((((....))))))......))))......(((((..((....))..)))))......((((((....)))))).)))))))..))))))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....((((((...(.....(..((((((.....))))))..).....)....))))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(.((((..(((((((((.......((((((.....)))))).....)))))))..)).)))).)..((((.((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))))..)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((((((....)))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((....(((.(....).)))....(((....))).))))).))).(...(......((((.(....(((((((((....)))...(((......)))...)))))).....((((.(.(((((..(((..((......)))))...))))).)..(..(((((.....))))).....)..)))).....).).))).......)..)....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((..((((....(.((....((...((.....))..))...)).)...))))..))))))..))).))))..).))...)..)..(((((((((....)))))))))}. Bacillus subtilis MutS2-collided disome complex (collided 70S); 16S rRNA (1533-MER) 8r55 U 77 3.57 RF00005 URS00002C7A07_1423 38177497 0030533 0006412 1423 gguccgguaguucaguugguuagaaugccugccugucacgcaggaggucgcggguucgagucccguccggaccgcca <<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.........)))).(((((.......)))))......((((.......)))).))))))).... Bacillus subtilis MutS2-collided disome complex (collided 70S); tRNA (77-MER) 8r55 V 33 3.57 38177497 1423 agaccaaugccauguacgucgcacucggaagac ................................. ................................. Bacillus subtilis MutS2-collided disome complex (collided 70S); mRNA (33-MER) 8r55 Y 112 3.57 RF00001 URS0000BC467F_1423 38177497 0003735 0005840 1423 ugguggcgauagcgaagaggucacacccguucccauaccgaacacggaaguuaagcucuucagcgccgaugguagucggggguuucccccugugagaguaggacgccgccaa <<<<<<<....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<.......<<.<<<<<...>>>>>.>>.......>>..>>>>>>>. (((((((....((((((((.....((((((...(.....)...))))..))....)))))).)).((.......((.(((((...))))).)).......))..))))))). Bacillus subtilis MutS2-collided disome complex (collided 70S); 5S rRNA (112-MER) 8r55 X 2887 3.57 RF02541 URS00005906D8_1423 38177497 0003735 0005840 1423 guuaaguuagaaagggcgcacgguggaugccuuggcacuaggagccgaugaaggacgggacgaacaccgauaugcuucggggagcuguaagcaagcuuugauccggagauuuccgaauggggaaacccaccacucguaauggagugguauccauaucugaauucauaggauaugagaaggcagacccggggaacugaaacaucuaaguacccggaggaagagaaagcaaaugcgauucccugaguagcggcgagcgaaacgggaucagcccaaaccaagaggcuugccucuugggguuguaggacacucgaacgagguagaugaagaggucuggaaaggcccgccauaggagguaacagcccuguagucaaaacuucguucgaguggauccugaguacggcggaacacgugaaauuccgucggaauccgggaggaccaucucccaaggcuaaauacucccuagugaccgauagugaaccaguaccgugagggaaaggugaaaagcaccccggaaggggagugaaagagauccugaaaccgugugccuacaaguagucagagcccguuaacgggugauggcgugccuuuuguagaaugaaccggcgaguuacgaucucgugcaagguuaagcagaagaugcggagccgcagcgaaagcgagucugaauagggcgcaugaguacguggucguagacccgaaaccaggugaucuacccauguccagggugaaguucagguaacacugaauggaggcccgaacccacgcacguugaaaagugcggggaugagguguggguaggggugaaaugccaaucgaaccuggagauagcugguucucuccgaaauagcuuuagggcuagccucaagguaagagucuuggagguagagcacugauuggacuaggggccccuaccggguuaccgaauucagucaaacuccgaaugccaaugacuuauccuugggagucagacugcgagugauaagauccguagucgaaagggaaacagcccagaccgccagcuaaggucccaaaguauacguuaaguggaaaaggauguggaguugcuuagacaaccaggauguuggcuuagaagcagccaccauuuaaagagugcguaauagcucacuggucgagugacucugcgccgaaaauguaccggggcuaaacguaucaccgaagcugcggacuguucgaacagugguaggagagcguucuaagggcugugaagccagaccggaaggacugguggagcgcuuagaagugagaaugccgguaugaguagcgaaagaggggugagaauccccuccaccgaaugccuaagguuuccugaggaaggcucguccgcucaggguuagucgggaccuaagccgaggccgaaaggcguaggcgauggacaacagguugauauuccuguaccaccuccucaccauuugagcaauggggggacgcaggaggauaggguaagcgcgguauuggauauccgcguccaagcaguuaggcugggaaauaggcaaauccguuucccaaaggcugagcugugauggcgagcgcgaaguuccugauuccacacugccaagaaaagccucuagcgaggugagaggugcccguaccgcaaaccgacacagguaggcgaggagagaauccuaaggugaucgagagaacucucguuaaggaacucggcaaaaugaccccguaacuucgggagaaggggugcucuguuagggugcaagcccgagagagccgcagugaauaggcccaggcgacuguuuagcaaaaacacaggucucugcgaagccguaaggcgaaguauaggggcugacgccugcccggugcuggaagguuaagaggagcgcuuagcguaagcgaaggugcgaauugaagccccaguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgacccgcacgaaaggcgcaacgaucugggcacugucucaacgagagacucggugaaauuauaguaccugugaagaugcagguuacccgcgacaggacggaaagaccccguggagcuuuacugcagccugauauugaauguugguacagcuuguacaggauagguaggagccuuggaaaccggagcgccagcuucgguggaggcaucggugggauacuacccuggcuguauugaccuucuaacccgccgcccuuaucgggcggggagacagugucaggugggcaguuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguucccucagaaugguuggaaaucauucgcagaguguaaaggcacaagggagcuugacugcgagaccuacaagucgagcagggacgaaagucgggcuuagugauccggugguuccgcauggaagggccaucgcucaacggauaaaagcuaccccggggauaacaggcuuaucucccccaagaguccacaucgacggggagguuuggcaccucgaugucggcucaucgcauccuggggcuguagucggucccaaggguugggcuguucgcccauuaaagcgguacgcgagcuggguucagaacgucgugagacaguucggucccuauccgucgcgggcgcaggaaauuugagaggagcuguccuuaguacgagaggaccgggauggacgcaccgcugguguaccaguuguucugccaagggcaucgcuggguagcuaugugcggacgggauaagugcugaaagcaucuaagcaugaagccccccucaagaugagauuucccauuccgcaaggaaguaagaucccugaaagaugaucagguugauaggucugagguggaaguguggcgacacauggagcugacagauacuaaucgaucgaggacuuaacc .<.<.<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<.....((.>>>.....<<<<<<<..<<<)).....>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<<<<<<<<.........>>>>>>>.>>.>>....<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<......<<.....>>.....>>>>...(((....<<<<<.<<....>>.>>>>>......<<<<<<<..<.<<<<<<<.<<<.....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>...>>>..>>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<......>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<.<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>......>>>>>.>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<...<<<<<<<<<.....<<<...<<<<<<<<...<<..<<<.....>>>...>>...>>>>>>>>..>>.>.....>>>>.>>>>>..>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<.....................>>......................>>>>>....>>>>>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<..>>>>>>....>>>>>><.<<<<<<<.<<......<<<<<.<<....>>.>>>>>...>>.>>>>>>>..>.....>>>>>><......<<....<<<<<<.......>>>>>><<<<....<<<<<.<<<..<<<<<<...<<.....>>.>>>>>>....((<<<<.<<.<.<<<...<<<....>>>...>>>..>>>...<<<<<........>>>>>))<<<<<.<<<<<<......<<...<<<<....<<<<..<<<..<<<.<<<<<<<<...(((....>>>>>><<..<<<<<..<<<<<<<<<<<.<<.....>>>>>>>>>...>>>>..>>>>>...>><..<..>...>>>>>>...>>>...>>>>.........>>>>..>>..>>>>>>>>>>>>>>>.>>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<<..............<<<<<....<....>.....>>>>><<<<<....<<<<....>>>>...>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>..<<<<.<<<..<<<<<<<..<<<...<<...<<<<<<.<<....>>..>>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>...>>.>>>>>>>....>>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<<.<<........<<.<.....................<<........<<..<<....>>..>>.....>>......................>.>>.......>.>....<<.<<<<<<.....>>>>>>>>.....>>>>>>>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.)))>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>.>... ...((.(......((((((((((.....(((..(((((((((((((......((((((.....[[[)))...].((.(((...(((]].....)))......))).))...)))....(((....)))(((((((......))))))).(((((((((.........))))))).)).))....((((((.....(...[..)......))))).).........((....))...((((......((.]...)).....))))...((((...(((((.((....)).)))))....{.(((((((....(((((((.(((...(.((((......)))))[[(...).(((.....]])))...)))...)))))))....)))..)))))....((((((((..[......))))))))....}.(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((..((((..[...))))..)))).<.(.(........).).((((((....(((((((.(((((..(((...(((.....)))...)))...((....))..((((.....))))......))))).)))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)<)))...(((.(((((.......A))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((...(((((((((.....(((...((((((((...((..(.((....)))...))...))))))))..)).).....)))).)))))..))))))).))..(((((((.((......)).)))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(.(((((..(.....{.(((((.(((....(.........)....)))..........(......)....)))))...)..))))).).))...........]]].)...))))))))))...)))))))((((((..))))))....))))))(.(((((...((......(((((.((....))])))))...))...)))))..).....))))))(......((....((((((.......))))))((((....(((...((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((.((((((......((...((((....((((..(((..(((.(((((((((...{{..).))))))((..(((((..(((.(((((((.((.....)))))))))....)))..)))))...))(..(..)...))))))...)))...))))(..).....))))..))..))))))))))))))).))).....((......))..))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.[..).....)))))(((((....((((....))))...)))))(...).......(((((((((.>.((.........))...(((((((.....(((....))).......))))))).]((((.(((..(((((((..(((...((...(((((..((....))...)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).[..(((((.....>].)))))..((((((((.(((.((......((((.((((((..(((((.(((((((((.((........(((((..).........(.......((.......(((..((....))..)))....)).................)....))))........))....((.((((((.....)))))))).....)))))))))..)))))..(((......[)))((((((..........]))))))([((...((.((((...(((((.........))))).....((]..[[[))....)))).))...((((..(((...{..)))..)))).(((....))).))]]].......(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..a.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..((((....))))....(((.(((((.......)))))....(.((((((.(((....(((((....)))))...)))..))))).).)....)))....).)).... Bacillus subtilis MutS2-collided disome complex (collided 70S); 23S RNA (2887-MER) 8r60 D 15 3.23 38563748 88776 aguagaaacaaggcc .<<....>>...... .((....))...... 1918 H1N1 Viral polymerase heterotrimer in complex with 4 repeat serine-5 phosphorylated PolII peptide; RNA (5'-R(P*AP*GP*UP*AP*GP*AP*AP*AP*CP*AP*AP*GP*GP*CP*C)-3') 8r62 A 11 NA URS0000BC466C_9606 38554107 9606 auacuuaccug ........... ........... Solution structure of Risdiplam bound to the RNA duplex formed upon 5'-splice site recognition; RNA (5'-R(*AP*UP*AP*CP*(PSU)P*(PSU)P*AP*CP*CP*UP*G)-3') 8r62 B 11 NA URS0000BC4661_9606 38554107 9606 ggaguaagucu ........... ........... Solution structure of Risdiplam bound to the RNA duplex formed upon 5'-splice site recognition; RNA (5'-R(P*GP*GP*AP*GP*UP*AP*AP*GP*UP*CP*U)-3') 8r63 A 11 NA URS0000BC466C_9606 38554107 9606 auacuuaccug ........... ........... Solution structure of branaplam bound to the RNA duplex formed upon 5'-splice site recognition; RNA (5'-R(*AP*UP*AP*CP*(PSU)P*(PSU)P*AP*CP*CP*UP*G)-3') 8r63 B 11 NA URS0000BC4661_9606 38554107 9606 ggaguaagucu ........... ........... Solution structure of branaplam bound to the RNA duplex formed upon 5'-splice site recognition; RNA (5'-R(P*GP*GP*AP*GP*UP*AP*AP*GP*UP*CP*U)-3') 8r65 D 15 4.23 38563748 88776 aguagaaacaaggcc .<<....>>...... .((....))...... 1918 H1N1 Viral polymerase heterotrimer in complex with 4 repeat serine-5 phosphorylated PolII peptide with ordered PB2 C-terminal domains; RNA (5'-R(P*AP*GP*UP*AP*GP*AP*AP*AP*CP*AP*AP*GP*GP*CP*C)-3') 8r6c A 1519 2.2 RF00177,RF01959,RF02542,RF01960 URS000081169C_679895 38826346 0003735 0005840 679895 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugccggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngaaccugcgguuggauca .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<......>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<.>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<..>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<..<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>.........>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((........))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((.)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((((())))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))...(......)..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... 70S Escherichia coli ribosome with Paenilamicin B2 bound with A- and P-site tRNA.; 16S ribosomal RNA 8r6c X 10 2.2 38826346 679895 auguugauau .......... .......... 70S Escherichia coli ribosome with Paenilamicin B2 bound with A- and P-site tRNA.; mRNA 8r6c Y 73 2.2 RF00005 38826346 0030533 679895 ggccccuuagcucagggagagcaggcgacucaunaucgcuuggucgcugguucaaguccagcaggggccacca <<<<<<<..<<<<.....>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[.))))((((((.......))))))....(((((..]....)))))))))))).... 70S Escherichia coli ribosome with Paenilamicin B2 bound with A- and P-site tRNA.; Isoeucine-tRNA 8r6c Z 72 2.2 RF00005 38826346 0030533 679895 gccgaaguggcgaaagggacgcaguugauucaanaucaaccguugccgguucgaguccggccuucggcacca <<<<<<<..<<<.......>>>.<<<<<<.....>>>>>>....<<<<<.......>>>>>>>>>>>>.... (((((((..(((....[..))).(((((.......)))))....(((((..]....)))))))))))).... 70S Escherichia coli ribosome with Paenilamicin B2 bound with A- and P-site tRNA.; Leucine-tRNA 8r6c a 2753 2.2 RF02541 38826346 0003735 0005840 679895 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagcgucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcgcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<..>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<..>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<..<<....>>...>>>>>..>....>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<..>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((((((.....))))).))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(())...)))..))))).))...........]]].)...))))))))))...)))))))((((((((()))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((())))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). 70S Escherichia coli ribosome with Paenilamicin B2 bound with A- and P-site tRNA.; 23S ribosomal RNA 8r6c b 119 2.2 RF00001 38826346 0003735 0005840 679895 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>> ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))) 70S Escherichia coli ribosome with Paenilamicin B2 bound with A- and P-site tRNA.; 5S ribosomal RNA 8r6u P 16 2.98 38709882 992210 acacagagacgcccag .<.....>........ .(.....)........ Structure of the SFTSV L protein in a transcription-priming state without capped RNA [TRANSCRIPTION-PRIMING (in vitro)]; RNA primer 8r6u T 17 2.98 URS000268137D_992210 38709882 992210 cugggcggucuuugugu ................. ................. Structure of the SFTSV L protein in a transcription-priming state without capped RNA [TRANSCRIPTION-PRIMING (in vitro)]; RNA (5'-R(P*CP*UP*GP*GP*GP*CP*GP*GP*UP*CP*UP*UP*UP*GP*UP*GP*U)-3') 8r6w P 16 3.35 38709882 992210 acacagagacgcccag .<.....>........ .(.....)........ Structure of the SFTSV L protein in a transcription-priming state with bound capped RNA [TRANSCRIPTION-PRIMING]; RNA (5'-R(*AP*CP*AP*CP*AP*GP*AP*GP*AP*CP*GP*CP*CP*CP*AP*G)-3') 8r6w T 17 3.35 URS000268137D_992210 38709882 992210 cugggcggucuuugugu ................. ................. Structure of the SFTSV L protein in a transcription-priming state with bound capped RNA [TRANSCRIPTION-PRIMING]; RNA (5'-R(P*CP*UP*GP*GP*GP*CP*GP*GP*UP*CP*UP*UP*UP*GP*UP*GP*U)-3') 8r6y P 16 3.4 38709882 992210 acacagagacgcccag .<.....>........ .(.....)........ Structure of the SFTSV L protein stalled in a transcription-specific early elongation state with bound capped RNA [TRANSCRIPTION-EARLY-ELONGATION]; RNA (5'-R(*AP*CP*AP*CP*AP*GP*AP*GP*AP*CP*GP*CP*CP*CP*AP*G)-3') 8r6y T 15 3.4 38709882 992210 cugggcgguaaaugu ............... ............... Structure of the SFTSV L protein stalled in a transcription-specific early elongation state with bound capped RNA [TRANSCRIPTION-EARLY-ELONGATION]; RNA (5'-R(P*CP*UP*GP*GP*GP*CP*GP*GP*UP*AP*AP*AP*UP*GP*U)-3') 8r8m b 119 2.4 RF00001 38826346 0003735 0005840 679895 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>> ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))) 70S Escherichia coli ribosome with Paenilamicin B2 bound with hybrid A/P- and hybrid P/E-tRNA.; 5S ribosomal RNA 8r8m X 10 2.4 38826346 679895 auguugauau .......... .......... 70S Escherichia coli ribosome with Paenilamicin B2 bound with hybrid A/P- and hybrid P/E-tRNA.; mRNA 8r8m a 2738 2.4 RF02541 38826346 0003735 0005840 679895 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagcgucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcgcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<..>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<..>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<..>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((.))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(..)...)))..))))).))...........]]].)...))))))))))...)))))))((((((((()))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(.(((.........))).)........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((())))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). 70S Escherichia coli ribosome with Paenilamicin B2 bound with hybrid A/P- and hybrid P/E-tRNA.; 23S ribosomal RNA 8r8m A 1519 2.4 RF00177,RF01959,RF02542,RF01960 URS000081169C_679895 38826346 0003735 0005840 679895 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugccggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngaaccugcgguuggauca .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<<....>>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<.>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<..>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<...<<....>>..>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((((((......)))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((.)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((((())))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))...(......)..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... 70S Escherichia coli ribosome with Paenilamicin B2 bound with hybrid A/P- and hybrid P/E-tRNA.; 16S ribosomal RNA 8r8m Z 72 2.4 RF00005 38826346 0030533 679895 gccgaaguggcgaaagggacgcaguugauucaanaucaaccguugccgguucgaguccggccuucggcacca <<<<<<<..<<<.......>>>.<<<<<<.....>>>>>>....<<<<<.......>>>>>>>>>>>>.... (((((((..(((....[..))).(((((.......)))))....(((((..]....)))))))))))).... 70S Escherichia coli ribosome with Paenilamicin B2 bound with hybrid A/P- and hybrid P/E-tRNA.; Leucine-tRNA 8r8m Y 73 2.4 RF00005 38826346 0030533 679895 ggccccuuagcucagggagagcaggcgacucaunaucgcuuggucgcugguucaaguccagcaggggccacca <<<<<<<..<<<<.....>>>><<<<<<.......>>>>>>....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[.))))((((((.......))))))....(((((..]....)))))))))))).... 70S Escherichia coli ribosome with Paenilamicin B2 bound with hybrid A/P- and hybrid P/E-tRNA.; Isoleucine-tRNA 8r8p A 11 NA URS0000BC466C_9606 38554107 9606 auacuuaccug ........... ........... Solution structure of SMN-CX bound to the RNA helix formed upon SMN2 exon7 5'-splice site recognition; RNA (5'-R(*AP*UP*AP*CP*(PSU)P*(PSU)P*AP*CP*CP*UP*G)-3') 8r8p B 11 NA URS0000BC4661_9606 38554107 9606 ggaguaagucu ........... ........... Solution structure of SMN-CX bound to the RNA helix formed upon SMN2 exon7 5'-splice site recognition; RNA (5'-R(P*GP*GP*AP*GP*UP*AP*AP*GP*UP*CP*U)-3') 8rcl 71 30 3.49 RF02541 38409277 0003735 0005840 562 acggcggccguaacnauaacgguccuaagg .....<<<<<<.......>>>>>>...... .....(((((.........)))))...... Escherichia coli paused disome complex (Non-rotated disome interface class 1); 23S ribosomal RNA 8rcl 72 2904 3.49 RF02541 38409277 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaucuu <<<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<..<<....>>..>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<..<<....>>...>>>>>..>....>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<<<<.............<...<<<....>>>...>....................>>>>...>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>.. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((((((.....))))).))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((.((....)).))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.(((..(.........((((.............((..(((....)))..))....................)))))..))).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))).. Escherichia coli paused disome complex (Non-rotated disome interface class 1); 23S ribosomal RNA 8rcl 82 120 3.49 RF00001 38409277 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Escherichia coli paused disome complex (Non-rotated disome interface class 1); 5S ribosomal RNA 8rcl A1 1542 3.49 RF00177,RF01959,RF02542,RF01960 38409277 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggaucaccuccuua ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<......>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<.......<<<....>>>......>>>>..<<.<<<<<........<<<<<<<<.......>>>>>>>>..........>>>>>....>>.<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<.....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>..>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<.<<<<.....>>>>.>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<.<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>..<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.......<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>........<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<..<<<<<....<<<<<..<<<...<<....>>.>.>>.>>>>>...>>>>>..>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.............. ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((((....))))))).)))))..)))))......(((.......((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..........)))))).)))))))..)).)))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..(((.......((((....))))......)))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((.(....(((((((...((........))......)))))))....).......((....))..))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((.(((.....))).))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(.(((((..(((((((....)))))))...(......)..)))))..)).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((.(...((..(((.....)))))....).)))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....))))))))..)).)))))))).(...(.((((......(((..((...(((....)))...))....)))......)))).)......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((.((((((....(((....((.(..((....)).).))...)))...))))).))))))..))).))))..).))...)..)..(((((((((....)))))))))}............. Escherichia coli paused disome complex (Non-rotated disome interface class 1); 16S ribosomal RNA 8rcl A2 1537 3.49 RF00177,RF01959,RF02542,RF01960 38409277 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggaucaccu ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<......>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..........>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<.......<<<....>>>......>>>>.....<<<<<........<<<.<<<<.......>>>>.>>>..........>>>>>.......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<....>>>>>>....<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<..<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>.........>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<..<.<<<<<<<........>>>>>>>>...>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<...<<....>>..>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(...(((.(((((......)))))..))).)..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....))).....(((((..(......))))))..)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((.....(((....)))...)))).)).))))))..((((.......(((....)))......))))..(..(((((...(....((..((((.......))))..)).....)....))))).....).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...((((((....))))))....((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((.(.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..).)).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........ Escherichia coli paused disome complex (Non-rotated disome interface class 1); 16S ribosomal RNA 8rcl V2 64 3.49 38409277 562 aaaaaggacggugagcuucgugacaauuaaaaaaaagguuucgcgcugggccaaaaucgaaaaa ................................................................ ................................................................ Escherichia coli paused disome complex (Non-rotated disome interface class 1); messenger RNA 8rcl W 76 3.49 RF00005 38409277 0030533 562 aggggcgnaguucaannggnagagcaccgguuuccanaaccgggunuugggagnucgagucucuccgccccugcca <<<<<<<..<<<<........>>>><<<<<<<.....>>>>>>.>...<<<<<.......>>>>>>>>>>>>.... (((((((..(.((.....[..)).).(((((.......))))).....(.(((..]....))).)))))))).... Escherichia coli paused disome complex (Non-rotated disome interface class 1); tRNA-Trp (P-site) 8rcl W1 36 3.49 38409277 562 nagcucagagagcaggggauugaanauccccgunuc ..<<<<...>>>>.<<<<<<.....>>>>>>..... ..((((...)))).((((.........))))..... Escherichia coli paused disome complex (Non-rotated disome interface class 1); tRNA-Phe (P-site) 8rcl X2 77 3.49 RF00005 38409277 0030533 562 gcauccgnagcucagcngganagaguacucggnuicgnaccgagcgnncggaggnucgaauccucccggaugcacca <<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.........)))).(((((.......))))).....(((((.......)))))))))))).... Escherichia coli paused disome complex (Non-rotated disome interface class 1); tRNA-Arg (E-site) 8rcl Y1 36 3.49 38409277 562 uagcucagagagcaccucccunacnaggaggggnuc ..<<<<...>>>>.<<<<<.......>>>>>..... ..((((...)))).(((((.......)))))..... Escherichia coli paused disome complex (Non-rotated disome interface class 1); tRNA-Val (A-site) 8rcl Y2 76 3.49 38409277 562 ggggcuauagcucagcngggagagcgcuugcauggcaugcaagagnucagcggnucgaucccgcuuagcuccacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).(((((.......))))).....(((((..]....)))))))))))).... Escherichia coli paused disome complex (Non-rotated disome interface class 1); tRNA-Ala (A-site) 8rcm 71 19 3.59 RF02541 38409277 0003735 0005840 562 ggccguaacnauaacgguc .<<<<<.......>>>>>. (((((.........))))) Escherichia coli paused disome complex (Non-rotated disome interface class 2); 23S ribosomal RNA 8rcm 72 2904 3.59 RF02541 38409277 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaucuu <<<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<..<<....>>..>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<..<<....>>...>>>>>..>....>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<..<<<.<<<<<.<<<<<<<<<<<.<<<............<<<<.............<...<<<....>>>...>....................>>>>...>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>...>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<.<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>...>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>.. (.((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....((((.((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))).))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((.(((..((((((((((.....(((...(((.((((...(((((((.....))))).))...)))).)))..)).).....)))))).)))..)))).))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((.((....)).))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.(((..(.........(((((............((..(((....)))..))...................))))))..))).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))).).. Escherichia coli paused disome complex (Non-rotated disome interface class 2); 23S ribosomal RNA 8rcm 82 120 3.59 RF00001 38409277 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Escherichia coli paused disome complex (Non-rotated disome interface class 2); 5S ribosomal RNA 8rcm A1 1542 3.59 RF00177,RF01959,RF02542,RF01960 38409277 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggaucaccuccuua ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<......>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>..<<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>>.<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<.....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>..>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<.....>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<.<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>..<<<.<<<..<<<<<<.<.....<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<<..<<<.....>>>>>.....>>>>>>.....<<<<<.....>>>>>........>>>>.....>...>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.......<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>........<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<..<<<<<....<<<<<..<<<...<<....>>.>.>>.>>>>>...>>>>>..>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.............. ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((((....))))))).)))))..)))))......(((.......((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..(......))))))).)))))))..)).)))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..(((.......((((....))))......)))..((.(((((...(...(((((((((.......)))))))).)...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((.(....(((((((...((........))......)))))))....).......((....))..))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((.(((.....))).))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(.....(((((..(((((((....)))))))...(......)..)))))...).((.(((...((.(((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((.(...((..(((.....)))))....).)))))..(..(((((.....))))).....)..)))).....).).))....)).)))))....))))))))..)).)))))))).(...(.((((......(((..((...(((....)))...))....)))......)))).)......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((.((((((....(((....((.(..((....)).).))...)))...))))).))))))..))).))))..).))...)..)..(((((((((....)))))))))}............. Escherichia coli paused disome complex (Non-rotated disome interface class 2); 16S ribosomal RNA 8rcm A2 1537 3.59 RF00177,RF01959,RF02542,RF01960 38409277 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggaucaccu ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<......>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..........>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<.<<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<.......<<<....>>>......>>>>.....<<<<<........<<<.<<<<.......>>>>.>>>..........>>>>>.......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<....>>>>>>....<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<..<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>.........>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<..<.<<<<<<<........>>>>>>>>...>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<...<<....>>..>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(...(((.(((((......)))))..))).)..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....))).....(((((..(......))))))..)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((.....(((....)))...)))).)).))))))..((((.......(((....)))......))))..(..(((((...(....((..((((.......))))..)).....)....))))).....).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((....(((((....))))).....((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((.(.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..).)).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........ Escherichia coli paused disome complex (Non-rotated disome interface class 2); 16S ribosomal RNA 8rcm V2 58 3.59 38409277 562 aaggacggugagcuucgugacaauuaaaaaaaagguuucgcgcugggccaaaaucgaa .......................................................... .......................................................... Escherichia coli paused disome complex (Non-rotated disome interface class 2); messenger RNA 8rcm W 76 3.59 RF00005 38409277 0030533 562 aggggcgnaguucaannggnagagcaccgguuuccanaaccgggunuugggagnucgagucucuccgccccugcca <<<<<<<..<<<<........>>>><<<<<<<.....>>>>>>.>...<<<<<.......>>>>>>>>>>>>.... (((((((..(.((.....[..)).).(((((.......))))).....(.(((..]....))).)))))))).... Escherichia coli paused disome complex (Non-rotated disome interface class 2); tRNA-Trp (P-site) 8rcm W1 36 3.59 38409277 562 nagcucagagagcaggggauugaanauccccgunuc ..<<<<...>>>>.<<<<<<.....>>>>>>..... ..((((...)))).((((.........))))..... Escherichia coli paused disome complex (Non-rotated disome interface class 2); tRNA-Phe (P-site) 8rcm X2 77 3.59 RF00005 38409277 0030533 562 gcauccgnagcucagcngganagaguacucggnuicgnaccgagcgnncggaggnucgaauccucccggaugcacca <<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.........)))).(((((.......))))).....(((((.......)))))))))))).... Escherichia coli paused disome complex (Non-rotated disome interface class 2); tRNA-Arg (E-site) 8rcm Y1 36 3.59 38409277 562 uagcucagagagcaccucccunacnaggaggggnuc ..<<<<...>>>>.<<<<<.......>>>>>..... ..((((...)))).((((.........))))..... Escherichia coli paused disome complex (Non-rotated disome interface class 2); tRNA-Val (A-site) 8rcm Y2 76 3.59 38409277 562 ggggcuauagcucagcngggagagcgcuugcauggcaugcaagagnucagcggnucgaucccgcuuagcuccacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).(((((.......))))).....(((((..]....)))))))))))).... Escherichia coli paused disome complex (Non-rotated disome interface class 2); tRNA-Ala (A-site) 8rcs 71 19 4.46 RF02541 38409277 0003735 0005840 562 ggccguaacnauaacgguc .<<<<<.......>>>>>. (((((.........))))) Escherichia coli paused disome complex (Rotated disome interface class 1); 23S ribosomal RNA 8rcs 72 2904 4.46 RF02541 38409277 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaucuu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<.......>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<..<<....>>..>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<..<<....>>...>>>>>..>....>>>>>>>>>..>>>>><<<<<.........>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<..<<<.<<<<<.<<<<<<<<<<..<<<.............<<<............<<<...<<....>>...>>>...................>>>....>>>..>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>...>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>.. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.(((......((...........)).......))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((.((....)).))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(.(((.........))).)........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((.(.(.(((..(............((...........(((.(.((....)))..)))..................))...)..))).).).)))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))).. Escherichia coli paused disome complex (Rotated disome interface class 1); 23S ribosomal RNA 8rcs 82 120 4.46 RF00001 38409277 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Escherichia coli paused disome complex (Rotated disome interface class 1); 5S ribosomal RNA 8rcs A1 1542 4.46 RF00177,RF01959,RF02542,RF01960 38409277 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggaucaccuccuua ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<......>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<......>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<.......<<<....>>>......>>>>..<<.<<<<<........<<<<<<<<.......>>>>>>>>..........>>>>>....>>.<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<.....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>..>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<.<<<<.....>>>>.>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<.<<<<<..<<<<<<<....>>>>>>>...<<<..>>>..>>>>>.>..<<<.<<<..<<<<<<.<.....<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.....>...>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.......<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>........<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<..<<<<<....<<<<<..<<<...<<....>>.>.>>.>>>>>...>>>>>..>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.............. ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((((....))))))).)))))..)))))......(((.......((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..(......))))))).)))))))..)).)))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.((((((..((((((((((......((((((.....))))))....))))))))..)).))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((.(((.....))).))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((.((((((..((((((((((......((........))........(.(((((((..(.....(((((..(((((((....)))))))...((....))..)))))...).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((.(...((..((.......))))....).)))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....))))))))..)).)))))))).(...(.((((......(((..((...(((....)))...))....)))......)))).)......(....(((((((........)))))))....)..)..))))))....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((.((((((....(((....((.(..((....)).).))...)))...))))).))))))..))).))))..).))...)..)..(((((((((....)))))))))}............. Escherichia coli paused disome complex (Rotated disome interface class 1); 16S ribosomal RNA 8rcs A2 1537 4.46 RF00177,RF01959,RF02542,RF01960 38409277 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggaucaccu ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<......>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..........>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<.......<<<....>>>......>>>>.....<<<<<........<<<.<<<<.......>>>>.>>>..........>>>>>.......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<....>>>>>>....<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.<.....<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<..<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>.........>>>.....>...>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<...<<....>>..>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(...(((.((((((....))))))..))).)..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....))).....(((((..(......))))))..)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((.....(((....)))...)))).)).))))))..((((......((((....)))).....))))..(..(((((...(....((..((((.......))))..)).....)....))))).....).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(.(((((...((((((....))))))....((....))..)))))..)).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((.(.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..).)).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........ Escherichia coli paused disome complex (Rotated disome interface class 1); 16S ribosomal RNA 8rcs V2 59 4.46 38409277 562 aaaaaggacggugagcuucgugacaauuaaaaaaaagguuucgcgcugggccaaaaucg ........................................................... ........................................................... Escherichia coli paused disome complex (Rotated disome interface class 1); messenger RNA 8rcs W 76 4.46 RF00005 38409277 0030533 562 aggggcgnaguucaannggnagagcaccgguuuccanaaccgggunuugggagnucgagucucuccgccccugcca <<<<<<<..<.<<........>>.>.<<<<<<.....>>>>>>......<<<<.......>>>>.>>>>>>>.... (((((((..(.((.....[..)).).(((((.......))))).....(.(((..]....))).)))))))).... Escherichia coli paused disome complex (Rotated disome interface class 1); tRNA-Trp (P/E-site) 8rcs W1 33 4.46 38409277 562 nagcucaagagcaggggauugaanauccccgun ..<<<<..>>>>.<<<<<<.....>>>>>>... ..((((..)))).((((.........))))... Escherichia coli paused disome complex (Rotated disome interface class 1); tRNA-Phe (P/E-site) 8rcs Y 76 4.46 38409277 562 ggggcuauagcucagcngggagagcgcuugcauggcaugcaagagnucagcggnucgaucccgcuuagcuccacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).(((((.......))))).....(((((..]....)))))))))))).... Escherichia coli paused disome complex (Rotated disome interface class 1); tRNA-Ala (A/P-site) 8rcs Y1 36 4.46 38409277 562 uagcucagagagcaccucccunacnaggaggggnuc ..<<<<...>>>>.<<<<<.......>>>>>..... ..((((...)))).(((((.......)))))..... Escherichia coli paused disome complex (Rotated disome interface class 1); tRNA-Val (A/P-site) 8rct 71 19 5.32 RF02541 38409277 0003735 0005840 562 ggccguaacnauaacgguc .<<<<<.......>>>>>. (((((.........))))) Escherichia coli paused disome complex (Rotated disome interface class 2); 23S ribosomal RNA 8rct 72 2904 5.32 RF02541 38409277 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaucuu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<.......>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<..<<....>>..>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>..>.....>>>>>>>>..>>>>><<<<<.........>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<..<<<.<<<<<.<<<<<<<<<<..<<<............<<<<............<<<...<<....>>...>>>...................>>>>...>>>..>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>...>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>.. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.(((......((...........)).......))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((.((....)).))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(.(((.........))).)........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((.(.(.(((..(.........((.((...........(((.(.((....)))..)))..................)).)))..))).).).)))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))).. Escherichia coli paused disome complex (Rotated disome interface class 2); 23S ribosomal RNA 8rct 82 120 5.32 RF00001 38409277 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Escherichia coli paused disome complex (Rotated disome interface class 2); 5S ribosomal RNA 8rct A1 1542 5.32 RF00177,RF01959,RF02542,RF01960 38409277 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggaucaccuccuua ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<......>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<......>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<.......<<<....>>>......>>>>..<<.<<<<<........<<<<<<<<.......>>>>>>>>..........>>>>>....>>.<<<<<(((...<<<<<.....<..))).>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<.....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>..>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<.<<<<.....>>>>.>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<.<<<<<..<<<<<<<....>>>>>>>...<<<..>>>..>>>>>.>..<<<.<<<..<<<<<<.<.....<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.....>...>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.......<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>........<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<..<<<<<....<<<<<..<<<...<<....>>.>.>>.>>>>>...>>>>>..>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.............. ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((((....))))))).)))))..)))))......(((.......((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..........)))))).)))))))..)).)))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(.(((....)))..))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.((((((..((((((((((......((((((.....))))))....))))))))..)).))))))..(((((((((...((((((.(....(((((((...((........))......)))))))....).......((....))..))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((.(((.....))).))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((.((((((..((((((((((......((........))........(.(((((((..(.....(((((..(((((((....)))))))...((....))..)))))...).((.(((...((.(((.(....(((((((((....)))...(((......)))...)))))).....(((..(((((.(...((..((.......))))....).)))))..(..(((((.....))))).....)...))).....).).))....)).)))))....))))))))..)).)))))))).(...(.((((......(((..((...(((....)))...))....)))......)))).)......(....(((((((........)))))))....)..)..))))))....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((.((((((....(((....((.(..((....)).).))...)))...))))).))))))..))).))))..).))...)..)..(((((((((....)))))))))}............. Escherichia coli paused disome complex (Rotated disome interface class 2); 16S ribosomal RNA 8rct A2 1537 5.32 RF00177,RF01959,RF02542,RF01960 38409277 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggaucaccu ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<......>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..........>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<.......<<<....>>>......>>>>.....<<<<<........<<<.<<<<.......>>>>.>>>..........>>>>>.......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.<.....<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<..<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>.........>>>.....>...>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<...<<....>>..>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(...(((.((((((....))))))..))).)..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....))).....(((((..(......))))))..)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((.....(((....)))...)))).)).))))))..((((.......(((....)))......))))..(..(((((...(....((..((((.......))))..)).....)....))))).....).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(.(((((....(((((....))))).....((....))..)))))..)).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((.(.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..).)).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........ Escherichia coli paused disome complex (Rotated disome interface class 2); 16S ribosomal RNA 8rct V2 59 5.32 38409277 562 aaaaaggacggugagcuucgugacaauuaaaaaaaagguuucgcgcugggccaaaaucg ........................................................... ........................................................... Escherichia coli paused disome complex (Rotated disome interface class 2); messenger RNA 8rct W 76 5.32 RF00005 38409277 0030533 562 aggggcgnaguucaannggnagagcaccgguuuccanaaccgggunuugggagnucgagucucuccgccccugcca <<<<<<<..<.<<........>>.>.<<<<<<.....>>>>>>......<<<<.......>>>>.>>>>>>>.... (((((((..(.((.....[..)).).(((((.......))))).....(.(((..]....))).)))))))).... Escherichia coli paused disome complex (Rotated disome interface class 2); tRNA-Trp (P/E-site) 8rct W1 36 5.32 38409277 562 nagcucagagagcaggggauugaanauccccgunuc ..<<<<...>>>>.<<<<<<.....>>>>>>..... ..((((...)))).((((.........))))..... Escherichia coli paused disome complex (Rotated disome interface class 2); tRNA-Phe (P/E-site) 8rct Y 76 5.32 38409277 562 ggggcuauagcucagcngggagagcgcuugcauggcaugcaagagnucagcggnucgaucccgcuuagcuccacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).(((((.......))))).....(((((..]....)))))))))))).... Escherichia coli paused disome complex (Rotated disome interface class 2); tRNA-Ala (A/P-site) 8rct Y1 36 5.32 38409277 562 uagcucagagagcaccucccunacnaggaggggnuc ..<<<<...>>>>.<<<<<.......>>>>>..... ..((((...)))).(((((.......)))))..... Escherichia coli paused disome complex (Rotated disome interface class 2); tRNA-Val (A/P-site) 8rd8 Z2 2705 2.62 RF02541 38355796 0003735 0005840 45610 gucaaguaaugaagcgcacaugguggaugccuuggcagucagaggcgaugaaagacgugacagccugcgauaagcuucggggaggcggcaauauccugugauccggagauuucugaauggggaaacccacuuaccauaagguagguaucuugaagaagcgaacgaggggaagugaaacaucucaguacccuuaggaaaagacaucaaaugagauuccccaaguagcggcgagcgaacggggagaagccgauuaaugcuaauguagaagaacagcgugggaaagcugaccguaguaggugauaguccuguauucgaaacauuagcguuaacauauuaaguagggcgggacacgagaaauccugucugaagauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccugugaggggagugaaauagaaccugaaaccgugugcguacaagcaguaggagccucaauuuauuggggugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccguuuaggggagccguagggaaaccgagucuuaauagggcguaguugcaggguauagacccgaaaccgagugaucuauccaugagcagguugaaagugccguaacaggcaccggaggaccgaacccacugucguugaaaagccaggggaugacuuguggauaggggugaaaggcuaaucaaacucggugauagcugguucuccccgaaagcuauuuagguagcgccucggacgaauaccauuggggguagagcacuguuucggcaccgaugcaaacuccgaauaccgaugaguaauauccgggagacacacggcgggugcuaacguccgucguggagagggaaacaacccagaccgccagcuaaggccccaaauuccuaguuaagugggaaacgaggugggaaggcauagacagcuaggagguuggcuuagaagcagccauccuuuaaagaaagcguaauagcucacuagucgagucggccugcgcggaagauguaacggggcucaaacuaggagccgaagcugcggauuugaaacuuguuuucaagugguaggggagcguuguguaagccugugaaggugugucguaaggcaugcuggagguaucacaagagcgaaugcugacgugaguaacgauaaugcgagugaaaagcucgcacgccggaagaucaaggguuccaguccaacguuaaucggggcugggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaauugguuaauauuccaauacuuguuuauagugcgauggagggacggagaagguuaugucagccuggcguugguuguccaggugaaaggauguaggcuuacaguuuaggcaaauccggacuguaggcugagaucugauagcaaggaaguggcaaauaccaugcuuccaggaaaagcuucuaagcgcuauaaacgaaucguacccuaaaccgacacaggugaucagguagagaauaccaaggcgcuugagagaacucugcugaaggaacuaggcaaaaugguaccguaacuucgggagaagguacgcuguugauggugauaggcuccuugagcuuucgacagucgcagauaccaggcugcugcaacuguuuauuaaaaacacagcacucugcaaacacgaaaguggacguauagggugugaugccugcccggugcuggaagguuaauugaugggguuagcguaagcgaagcucuugaucgaagccccaguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucagguaaguucugaccugcacgaauggcauaaugauggcagcgcugucuccagcagagacucagugaaaucgaaaucgcagugaagaugcuguguacccgcggcuagacggaaagaccccgugaaccuuuacuacagcuuuacauugaacuuggguucuaacucagguauaacaauaccgaggacaauguaugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggaguacgaaggugcgcucagaacggucggaaaucguucauagaguauaaaggcaaaagcgcgcuuaacugcgagacccacaagucgagcagguacgaaaguaggucuuagugauccggugguucuguauggaagggccaucgcucaacggauaaaagguacucuggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucucauccuagggcugaagcagguccuaaggguauggcuguucgccauuuaaagagguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucuaccgugggcguuggaaauuugagaggaucugcuccuaguacgagaggaccagaguggacgaaccucugguguucggguugucacgccaguggcauugcccgguagcuacguucggaugggauaaccgcugaaagcaucuaagcgggaagcccaccucaagauuagauuucccuaaagagccguugaagacuacgacguugauaggcaggguguggaagugcagcgaugcauguagcuaaccuguacuaauugcucguuuggcuugacc <<<<<<<......<<<<<<<<<<<.....[[.<<<<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<.)))..]..>>.....>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<.>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..((...<<<<<<<<<<<<<.<<<...<<<<........>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>...))......]].>>>>>>>.>>>..............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<<....>>>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<....<<<<<......>>>>>..>...>>>...<<<.<<<.<........>.>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<....<<<<<<<<<.....<<<...<<<.<<<<..>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<<..<<<<.......>>>>..>>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<...((((...>>>>>>....<<<<...<<<<.<<<<<<..<<.....>>.>>>>>>.>>>>...>>>>.............>>>>>...>>>...>>>>.........>>>>...>>>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<<<.<<<...<<<..>>>...>>>.>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<..<<....>>...>>>>>.>.....>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<.<<<<.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<..>>>>>...<<<.<<<<<....>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<.................>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))))>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>...>>>>.....>>>>>>>. (((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...((.]]]..]..))......))))))...)))....(((....)))(((((((....))))))).((((.)))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((.(((((.((.(((...((((........))))[[(...).(((.....]])))...)))...)).))))).)))))..........((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((((....)))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....))))...)))))))))))))..((.(...((((((.....((((((((((.((((....(((((......)))))....)[)))...(((.(((.(.......<).))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).(((((((...((((((((((.....(((...(((.((((..)))).)))..)).).....)))))).))).).)))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((.((..(((.....{.(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..)).)).))...........]]].)....))))))))))...)))))))((((((.(.....).))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))...((((........)))).]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))....(((....((((.(((((((.((.....))))))))).))))..[.))).....(......))))))...)))...))))(..).....))))...))))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((.(((...(((].)))...))).))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..(((((((..(((.((......(((..((((((..(((((.(((.(((((.(((((..)))))...(((.(((((....))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..)).)))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))..>.))..))).)))))))[...(((((((...((((..((((((......(....).....)))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....)))))))). Cryo-EM structure of P. urativorans 70S ribosome in complex with hibernation factors Balon and RaiA (structure 1).; 23S rRNA 8rd8 D8 115 2.62 RF00001 38355796 0003735 0005840 45610 gcugacgaccauagcacgauggcaccaccugaucccuucccgaacucagaagugaaacaucgucgcgccaaugguagugugguuucgaccaugugagaguaggucaucgucagcu <<<<<<<<.....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<....>>>>>>>.......>>>..>>>>>>>>. ((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......(((((((....))))))).......)))..)))))))). Cryo-EM structure of P. urativorans 70S ribosome in complex with hibernation factors Balon and RaiA (structure 1).; 5S rRNA 8rd8 iN 1503 2.62 RF00177,RF01959,RF02542,RF01960 38355796 0003735 0005840 45610 aaacugaagaguuugaucauggcucagauugaacgcuggcggcaggcuuaacacaugcaagucgagcgguaacaggagaagcuugcuucuugcugacgagcggcggacgggugaguaauacuuaggaaucuaccuaguagugggggauagcucggggaaacucgaauuaauaccgcauacgaccuacgggagaaagggggcucucgcuauuagaugagccuaagucggauuagcuagauggugggguaaaggccuaccauggcgacgaucuguagcuggucugagaggaugaucagccacaccgggacugagacacggcccggacuccuacgggaggcagcaguggggaauauuggacaaugggggcaacccugauccagccaugccgcgugugugaagaaggccuuuugguuguaaagcacuuuaagcagugaagaagacuccgugguuaauacccacggacgaugacauuagcugcagaauaagcaccggcuaacucugugccagcagccgcgguaauacagagggugcaagcguuaaucggaauuacugggcguaaagggagcguagguggcucgauaagucagaugugaaauccccgggcuuaaccugggaacugcaucugauacuguugagcuagaguaugugagaggaagguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgauggcgaaggcagccuucuggcauaauacugacacugaggcucgaaagcguggguagcaaacaggauuagauacccugguaguccacgccguaaacgaugucuacuagucguuggguccggacuuagugacgcagcuaacgcaauaaguagaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcauguuguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauaucuagaauccugcagagaugcgggagugccuucgggaauuagaauacaggugcugcauggcugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuuguccuuaguuaccagggaacucuaaggauacugccagugacaaacuggaggaaggcggggacgacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaaugguagguacagagggcagcuacacagcgaugugaugcgaaucucaaaaagccuaucguaguccggauuggagucugcaacucgacuccaugaaguaggaaucgcuaguaaucgcggaucagaaugccgcggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguugauugcaccagaaguggauagcuuaaccuucgggaaggcguucaccacggugugguugaugacuggggugaagucguaacaagguagccguaggggaaccugcggcuggauc ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<..........>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<<<.<<....<.<<<<<....>>>>>.>.....>>.>......<<....>>.....<<<<..>>>>>>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<.........<<<<<<<.......>>>>>>>...........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<.<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<<..>>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<<<<<<<<<...<<..>>....>>>>>>>>....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>..>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((.((..........))..)))))..)))))......(((.......((((((..((...(((((((((.((......(((((....))))).......)).)......((....)).....((((()))))))))))))..)).)))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(.....(((((((.......)))))))......)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((((())))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..(((((((.((......((........))..........(((((((..(...(((.((...(((.(((....))).)))...((....))...).).)))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...))..))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((....((....))...))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Cryo-EM structure of P. urativorans 70S ribosome in complex with hibernation factors Balon and RaiA (structure 1).; 16S rRNA 8rdv Z2 2710 2.6 RF02541 38355796 0003735 0005840 45610 gucaaguaaugaagcgcacaugguggaugccuuggcagucagaggcgaugaaagacgugacagccugcgauaagcuucggggaggcggcaauauccugugauccggagauuucugaauggggaaacccacuuaccauaagguagguaucuuguacaagaagcgaacgaggggaagugaaacaucucaguacccuuaggaaaagacaucaaaugagauuccccaaguagcggcgagcgaacggggagaagccgauuaaugcuaauguagaagaacagcgugggaaagcugaccguaguaggugauaguccuguauucgaaacauuagcguuaacauauuaaguagggcgggacacgagaaauccugucugaagauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccugugaggggagugaaauagaaccugaaaccgugugcguacaagcaguaggagccucaauuuauuggggugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccguuuaggggagccguagggaaaccgagucuuaauagggcgucuaguugcaggguauagacccgaaaccgagugaucuauccaugagcagguugaaagugccguaacaggcaccggaggaccgaacccacugucguugaaaagccaggggaugacuuguggauaggggugaaaggcuaaucaaacucggugacagcugguucuccccgaaagcuauuuagguagcgccucggacgaauaccauuggggguagagcacuguuucggcaccgaugcaaacuccgaauaccgaugaguaauauccgggagacacacggcgggugcuaacguccgucguggagagggaaacaacccagaccgccagcuaaggccccaaauuccuaguuaagugggaaacgaggugggaaggcauagacagcuaggagguuggcuuagaagcagccauccuuuaaagaaagcguaauagcucacuagucgagucggccugcgcggaagauguaacggggcucaaacuaggagccgaagcugcggauuugaaacuuguuuucaagugguaggggagcguuguguaagccugugaaggugugucguaaggcaugcuggagguaucacaagagcgaaugcugacgugaguaacgauaaugcgagugaaaagcucgcacgccggaagaucaaggguuccaguccaacguuaaucggggcugggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaauugguuaauauuccaauacuuguuuauagugcgauggagggacggagaagguuaugucagccuggcguugguuguccaggugaaaggauguaggcuuacaguuuaggcaaauccggacuguaggcugagaucugauagcaaggaaguggcaaauaccaugcuuccaggaaaagcuucuaaggcuauaaacgaaucguacccuaaaccgacacaggugaucagguagagaauaccaaggcgcuugagagaacucugcugaaggaacuaggcaaaaugguaccguaacuucgggagaagguacgcuguugauggugauaggucuccuugagcuuucgacagucgcagauaccaggcugcugcaacuguuuauuaaaaacacagcacucugcaaacacgaaaguggacguauagggugugaugccugcccggugcuggaagguuaauugaugggguuagcguaagcgaagcucuugaucgaagccccaguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucagguaaguucugaccugcacgaauggcauaaugauggcagcgcugucuccagcagagacucagugaaaucgaaaucgcagugaagaugcuguguacccgcggcuagacggaaagaccccgugaaccuuuacuacagcuuuacauugaacuuggguucuaacucagguauaacaauaccgaggacaauguaugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggaguacgaaggugcgcucagaacggucggaaaucguucauagaguauaaaggcaaaagcgcgcuuaacugcgagacccacaagucgagcagguacgaaaguaggucuuagugauccggugguucuguauggaagggccaucgcucaacggauaaaagguacucuggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucucauccuagggcugaagcagguccuaaggguauggcuguucgccauuuaaagagguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucuaccgugggcguuggaaauuugagaggaucugcuccuaguacgagaggaccagaguggacgaaccucugguguucggguugucacgccaguggcauugcccgguagcuacguucggaugggauaaccgcugaaagcaucuaagcgggaagcccaccucaagauuagauuucccuaaagagccguugaagacuacgacguugauaggcaggguguggaagugcagcgaugcauguagcuaaccuguacuaauugcucguuuggcuugacc <<<<<<<......<<<<<<<<<<<.....<<.<<<<<<<<<<<<<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<.)))..]..>>.....>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<<<<<<<<<<.<<<...<<<<........>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...........<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>>.>>>..............<<....>>....>>.........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<<....>>>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<....<<<<<......>>>>>..>...>>>...<<<.<<<.<........>.>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<....<<<<<<<<<.....<<<...<<<.<<<<..>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<<..<<<<.......>>>>..>>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........)))......>>>>>>.>>>...>>>>>>><<<<<<.<.....>.>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<.<...<<<<....<<<<..<<<..<<<<<<<<<<<...[[[[...>>>>>>....<<<<...<<<<<<<<<<<..<<.....>>.>>>>>>>>>>>...>>>>.............>>>>>...>>>...>>>>.........>>>>...>>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<<<.<<<...<<<...>>>...>>>.>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<<.<<....>>..>>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<.<<<<.<<......<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<..>>>>>...<<<.<<<<<....>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<.................>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>...>>>>.....>>>>>>>. (((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...((.]]]..]..))......))))))...)))....(((....)))(((((((....))))))).(((((..))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((.(((((.((.(((...((((........))))[[(...).(((.....]])))...)))...)).))))).)))))..........((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((((....)))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((....(((((......)))))....)[)))...(((.(((.(.......<).))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).(((((((...((((((((((.....(((...(((.((((..)))).)))..)).).....)))))).))).).)))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)....))))))))))...)))))))((((((.(.....).))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))...((((........)))).]](((((((((((.(...((((....((((..(((..((((((((((((...{{{.).))))))....(((....((((((((((((.((.....))))))))))))))..[.))).....(......))))))...)))...))))(..).....))))...)))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((.(((...(((.].)))...))).))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..(((((((..(((.((......(((..((((((..(((((.(((.(((((.((((....))))...(((.((((......)))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..)).)))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))..>.))..))).)))))))[...((((.((...((((..((((((......(....).....)))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)).))))(....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....)))))))). Cryo-EM structure of P. urativorans 70S ribosome in complex with hibernation factor Balon, mRNA and P-site tRNA (structure 2).; 23S rRNA 8rdv D8 115 2.6 RF00001 38355796 0003735 0005840 45610 gcugacgaccauagcacgauggcaccaccugaucccuucccgaacucagaagugaaacaucgucgcgccaaugguagugugguuucgaccaugugagaguaggucaucgucagcu <<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>><<<.......<<<<<<<<..>>>>>>>>.......>>>..>>>>>>>>. ((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......(((((((....))))))).......)))..)))))))). Cryo-EM structure of P. urativorans 70S ribosome in complex with hibernation factor Balon, mRNA and P-site tRNA (structure 2).; 5S rRNA 8rdv V 76 2.6 38355796 45610 uuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuacca ............................................................................ ............................................................................ Cryo-EM structure of P. urativorans 70S ribosome in complex with hibernation factor Balon, mRNA and P-site tRNA (structure 2).; Heterogenous tRNA 8rdv iN 1503 2.6 RF00177,RF01959,RF02542,RF01960 38355796 0003735 0005840 45610 aaacugaagaguuugaucauggcucagauugaacgcuggcggcaggcuuaacacaugcaagucgagcgguaacaggagaagcuugcuucuugcugacgagcggcggacgggugaguaauacuuaggaaucuaccuaguagugggggauagcucggggaaacucgaauuaauaccgcauacgaccuacgggagaaagggggcucucgcuauuagaugagccuaagucggauuagcuagauggugggguaaaggccuaccauggcgacgaucuguagcuggucugagaggaugaucagccacaccgggacugagacacggcccggacuccuacgggaggcagcaguggggaauauuggacaaugggggcaacccugauccagccaugccgcgugugugaagaaggccuuuugguuguaaagcacuuuaagcagugaagaagacuccgugguuaauacccacggacgaugacauuagcugcagaauaagcaccggcuaacucugugccagcagccgcgguaauacagagggugcaagcguuaaucggaauuacugggcguaaagggagcguagguggcucgauaagucagaugugaaauccccgggcuuaaccugggaacugcaucugauacuguugagcuagaguaugugagaggaagguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgauggcgaaggcagccuucuggcauaauacugacacugaggcucgaaagcguggguagcaaacaggauuagauacccugguaguccacgccguaaacgaugucuacuagucguuggguccggacuuagugacgcagcuaacgcaauaaguagaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcauguuguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauaucuagaauccugcagagaugcgggagugccuucgggaauuagaauacaggugcugcauggcugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuuguccuuaguuaccagggaacucuaaggauacugccagugacaaacuggaggaaggcggggacgacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaaugguagguacagagggcagcuacacagcgaugugaugcgaaucucaaaaagccuaucguaguccggauuggagucugcaacucgacuccaugaaguaggaaucgcuaguaaucgcggaucagaaugccgcggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguugauugcaccagaaguggauagcuuaaccuucgggaaggcguucaccacggugugguugaugacuggggugaagucguaacaagguagccguaggggaaccugcggcuggauc ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<..........>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<<<.<<....<.<<<<......>>>>.>.....>>.>......<<....>>.....<<<<..>>>>>>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<.........<<<<<<<.......>>>>>>>...........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<.<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<<..>>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<<<<<<<<<...<<..>>....>>>>>>>>....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>..>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((.((..........))..)))))..)))))......(((.......((((((..((...(((((((((.((......(((((....))))).......)).)......((....)).....((((()))))))))))))..)).)))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(.....(((((((.......)))))))......)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((((())))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..(((((((.((......((........))..........(((((((..(...(((.((...(((.(((....))).)))...((....))...).).)))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...))..))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((....((....))...))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Cryo-EM structure of P. urativorans 70S ribosome in complex with hibernation factor Balon, mRNA and P-site tRNA (structure 2).; 16S rRNA 8rdw Z2 2729 2.74 RF02541 38355796 0003735 0005840 45610 gucaaguaaugaagcgcacaugguggaugccuuggcagucagaggcgaugaaagacgugacagccugcgauaagcuucggggaggcggcaauauccugugauccggagauuucugaauggggaaacccacuuaccauaagguagguaucuuguacaagaagcgaacgaggggaagugaaacaucucaguacccuuaggaaaagacaucaaaugagauuccccaaguagcggcgagcgaacggggagaagccgauuaaugcuaauguagaagaacagcgugggaaagcugaccguaguaggugauaguccuguauucgaaacauuagcguuaacauauuaaguagggcgggacacgagaaauccugucugaagauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccugugaggggagugaaauagaaccugaaaccgugugcguacaagcaguaggagccucaauuuauuggggugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccguuuaggggagccguagggaaaccgagucuuaauagggcgucuaguugcaggguauagacccgaaaccgagugaucuauccaugagcagguugaaagugccguaacaggcaccggaggaccgaacccacugucguugaaaagccaggggaugacuuguggauaggggugaaaggcuaaucaaacucggugauagcugguucuccccgaaagcuauuuagguagcgccucggacgaauaccauuggggguagagcacuguuucggcuagggggucauaccgacuaaccgaugcaaacuccgaauaccgaugaguaauauccgggagacacacggcgggugcuaacguccgucguggagagggaaacaacccagaccgccagcuaaggccccaaauuccuaguuaagugggaaacgaggugggaaggcauagacagcuaggagguuggcuuagaagcagccauccuuuaaagaaagcguaauagcucacuagucgagucggccugcgcggaagauguaacggggcucaaacuaggagccgaagcugcggauuugaaacuuguuuucaagugguaggggagcguuguguaagccugugaaggugugucguaaggcaugcuggagguaucacaagagcgaaugcugacgugaguaacgauaaugcgagugaaaagcucgcacgccggaagaucaaggguuccaguccaacguuaaucggggcugggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaauugguuaauauuccaauacuuguuuauagugcgauggagggacggagaagguuaugucagccuggcguugguuguccaggugaaaggauguaggcuuacaguuuaggcaaauccggacuguaggcugagaucugauagcaaggaaguggcaaauaccaugcuuccaggaaaagcuucuaaggcuauaaacgaaucguacccuaaaccgacacaggugaucagguagagaauaccaaggcgcuugagagaacucugcugaaggaacuaggcaaaaugguaccguaacuucgggagaagguacgcuguugauggugauaggucuccuugagcuuucgacagucgcagauaccaggcugcugcaacuguuuauuaaaaacacagcacucugcaaacacgaaaguggacguauagggugugaugccugcccggugcuggaagguuaauugaugggguuagcguaagcgaagcucuugaucgaagccccaguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucagguaaguucugaccugcacgaauggcauaaugauggcagcgcugucuccagcagagacucagugaaaucgaaaucgcagugaagaugcuguguacccgcggcuagacggaaagaccccgugaaccuuuacuacagcuuuacauugaacuuggguucuaacucagguauaacaauaccgaggacaauguaugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggaguacgaaggugcgcucagaacggucggaaaucguucauagaguauaaaggcaaaagcgcgcuuaacugcgagacccacaagucgagcagguacgaaaguaggucuuagugauccggugguucuguauggaagggccaucgcucaacggauaaaagguacucuggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucucauccuagggcugaagcagguccuaaggguauggcuguucgccauuuaaagagguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucuaccgugggcguuggaaauuugagaggaucugcuccuaguacgagaggaccagaguggacgaaccucugguguucggguugucacgccaguggcauugcccgguagcuacguucggaugggauaaccgcugaaagcaucuaagcgggaagcccaccucaagauuagauuucccuaaagagccguugaagacuacgacguugauaggcaggguguggaagugcagcgaugcauguagcuaaccuguacuaauugcucguuuggcuugacc <<<<<<<......<<<<<<<<<<<.....<<.<<<<<<<<<<<<<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<.)))..]..>>.....>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<<<<<<<<<<.<<<...<<<<........>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...........<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>>.>>>..............<<....>>....>>.........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<<....>>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<<....<<<<<......>>>>>..>...>>>...<<<.<<<.<........>.>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<....<<<<<<<<<.....<<<...<<<.<<<<.....<<..........>>..>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<<..<<<<.......>>>>..>>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........)))......>>>>>>.>>>...>>>>>>><<<<<<.<.....>.>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<.<...<<<<....<<<<..<<<..<<<<<<<<<<<...[[[[...>>>>>>....<<<<...<<<<<<<<<<<..<<.....>>.>>>>>>>>>>>...>>>>.............>>>>>...>>>...>>>>.........>>>>...>>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<<<.<<<...<<<...>>>...>>>.>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<<.<<....>>..>>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<.<<<<.<<......<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<..>>>>>...<<<.<<<<<....>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<.................>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>...>>>>.....>>>>>>>. (((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...((.]]]..]..))......))))))...)))....(((....)))(((((((....))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((.(((((.((.(((...((((........))))[[(...).(((.....]])))...)))...)).))))).)))))..........((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((((....)))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((....(((((......)))))....)[)))...(((.(((.(.......<).))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).(((((((...((((((((((.....(((...(((.((((......(..........)...)))).)))..)).).....)))))).))).).)))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)....))))))))))...)))))))((((((.(.....).))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))...((((........)))).]](((((((((((.(...((((....((((..(((..((((((((((((...{{{.).))))))....(((....(((..(((((((.((.....)))))))))..)))..[.))).....(......))))))...)))...))))(..).....))))...)))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((.(((...(((.].)))...))).))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..(((((((..(((.((......(((..((((((..(((((.(((.(((((.(((((..)))))...(((.((((......)))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..)).)))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))..>.))..))).)))))))[...((((.((...((((..((((((......(....).....)))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)).))))(....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....)))))))). Cryo-EM structure of P. urativorans 70S ribosome in complex with hibernation factor Balon and EF-Tu(GDP) (structure 3).; 23S rRNA 8rdw D8 115 2.74 RF00001 38355796 0003735 0005840 45610 gcugacgaccauagcacgauggcaccaccugaucccuucccgaacucagaagugaaacaucgucgcgccaaugguagugugguuucgaccaugugagaguaggucaucgucagcu <<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>><<<.......<<<<<<<<..>>>>>>>>.......>>>..>>>>>>>>. ((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......(((((((....))))))).......)))..)))))))). Cryo-EM structure of P. urativorans 70S ribosome in complex with hibernation factor Balon and EF-Tu(GDP) (structure 3).; 5S rRNA 8rdw iN 1503 2.74 RF00177,RF01959,RF02542,RF01960 38355796 0003735 0005840 45610 aaacugaagaguuugaucauggcucagauugaacgcuggcggcaggcuuaacacaugcaagucgagcgguaacaggagaagcuugcuucuugcugacgagcggcggacgggugaguaauacuuaggaaucuaccuaguagugggggauagcucggggaaacucgaauuaauaccgcauacgaccuacgggagaaagggggcucucgcuauuagaugagccuaagucggauuagcuagauggugggguaaaggccuaccauggcgacgaucuguagcuggucugagaggaugaucagccacaccgggacugagacacggcccggacuccuacgggaggcagcaguggggaauauuggacaaugggggcaacccugauccagccaugccgcgugugugaagaaggccuuuugguuguaaagcacuuuaagcagugaagaagacuccgugguuaauacccacggacgaugacauuagcugcagaauaagcaccggcuaacucugugccagcagccgcgguaauacagagggugcaagcguuaaucggaauuacugggcguaaagggagcguagguggcucgauaagucagaugugaaauccccgggcuuaaccugggaacugcaucugauacuguugagcuagaguaugugagaggaagguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgauggcgaaggcagccuucuggcauaauacugacacugaggcucgaaagcguggguagcaaacaggauuagauacccugguaguccacgccguaaacgaugucuacuagucguuggguccggacuuagugacgcagcuaacgcaauaaguagaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcauguuguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauaucuagaauccugcagagaugcgggagugccuucgggaauuagaauacaggugcugcauggcugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuuguccuuaguuaccagggaacucuaaggauacugccagugacaaacuggaggaaggcggggacgacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaaugguagguacagagggcagcuacacagcgaugugaugcgaaucucaaaaagccuaucguaguccggauuggagucugcaacucgacuccaugaaguaggaaucgcuaguaaucgcggaucagaaugccgcggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguugauugcaccagaaguggauagcuuaaccuucgggaaggcguucaccacggugugguugaugacuggggugaagucguaacaagguagccguaggggaaccugcggcuggauc ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<..........>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<<<.<<....<.<<<<......>>>>.>.....>>.>......<<....>>.....<<<<..>>>>>>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<.........<<<<<<<.......>>>>>>>...........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<.<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<<..>>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<<<<<<<<<...<<..>>....>>>>>>>>....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>..>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((.((..........))..)))))..)))))......(((......(((((((..((...(((((((((.((......(((((....))))).......)).)......((....)).....((((()))))))))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(.....(((((((.......)))))))......)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((((())))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..(((((((.((......((........))..........(((((((..(...(((.(((..(((((((....)))))))...((....))..)).).)))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...))..))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((....((....))...))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Cryo-EM structure of P. urativorans 70S ribosome in complex with hibernation factor Balon and EF-Tu(GDP) (structure 3).; 16S rRNA 8rjb K 3543 2.69243 RF02543 URS0000A7632C_9986 38896445,28710774,29872003,34783343 0003735 0005840 9986 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggaaauguggcguacggaagacccacuccccggcgccggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcgcgguccggccgugccggcggggcggaucucccgcucccgucggcgggggaccgccccccggccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggccccggcggggaagguggcccgggggccccggguguuacagccccgccccggcagcagcagcucgccgaaucccggggccgagggagcgagacccgugcgccgcgcucuccccccucgggggggccgggccaccccucccacggcgcgaccgcuggggcggacuguccagugcgccccgggcgggucgcgccgucgggcccggggggccacgcgucccccgcgagcgcacggggucggcggcgaugucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcuacgaaagccgccguggcgcaaugaaggugaaggccggcggcgcgccgccggccgaggugggaucccgaggccuuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcgaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccaaaguuucccucaggauagcuggcgcucuccgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcugguguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggaugguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgcuggcagucggcagagcgagaaagagaguggcgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucagccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcuggcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacguuuuuucacugacccggugaggcgggggggcgagccgggcucucgcuucuggcgccaagcgcccggccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauagcgccggagccucgguuggccucggauagccggucccccgccgggguccggugcggagagcccuucgucccgggaaacggggcggccggaaagggggccgcccucucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcugcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>>..<<<<<<<<<....<<<<<<<<..<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>...>>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<.<....<<<<<<<<.<<<.....<<<<<<<<<<....<<<<<<<.<<<<<.<<<<<<<.<<<<<<<<<......>>>>>>>>>>>>>>>>>>>>>>>>>...>>>.>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<<<<<<<<<<<<<<<<<...<<..<<<..<<<<<<<......<<<<<<<<.>>>>>>>>.......>>>>>>>..>>>.........>>>>>>..>>>>>>>>>>>.....<<.....{.>>.........<...<<<<<<..>>>>>>...<.<<..<<<.<<<<<<<<<<<<<<<<<<<<<<<.<<<<..>>>>.>>>>>>.>>>.>>>>>>>>>>>.>>>...>>>>>.>................>........>>>.>>>>>....>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<.....>>>>.....>>>...<<....>>...<<<<<<<<<<..>>>>>>>>>>..<<<<<...<<<..<<<...(((.[[.>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<...<<<.<<<<<<<<<...<<<....<<<..<.<<<..<<<<<<.<.....>.>>>>>>>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<...<<....<..........>...>>.......................>.>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<........}...........]].)))............>>>>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<<<<<...>>>>>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<..<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<.>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<<<..>>>>>>>>>...<<<<<.....<<<<..<<.<..<<>>..>.>>..............<<<<<<<<<..>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>><<<<....>>>>>>)))].....<<<<<<<..<<<..)))))).>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<]]].>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.<<<<<<<..<<<<....<<<........<<<<<..<<<<<.>>>>>.>>>>>.......>>>...<<<..<<<<....<<<<<<<<..........>>>>>.>>>...>>>>..>>>..............>>>>..>.>>>>>>.<<<<<.<.............>....<<.<<<<<<<.<<.....<<<<.<..<<<<<.>>>>>..>>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..(((((((((((.....)))))).))))....))))....(((((((((....((((((((..((((((((..({((((......)))))....[[(...).(((....}]])))...).)))))))...))))))))...)))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....((((((((((.(..(((((((.(((((.(((((((.((.((((((......)))))).))))))))))))))))))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((..(((((((......((((((((.)))))))).......)))))))..))).........))))))..))))))))))).....((.....{.)).........(.(.((((((()))))))...(.((..(((.((((((((((((((.((((((((.((((..)))).)))))).))..))))))))))).)))...))))).)............[.).)........))).)))))...)))))...)))))))).<((((........))))((((((....(((((((((((((..(((..(((((.....))))..)..)))...((....))...((((((((((()))))))))))..(((((...(((..(((]..[[[.[[[)))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......B)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((...(((.((((((((....(((....(((..(.(((..((((((.(.....).))))))))).)..)))..)).)....))))))...(((((((((.(......))))))))))....))))))))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.....A....(...((....(..........)...))......(..............).).......)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((........}.........].]].]]]............)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...((..(.(((....))).....)....((.(((((((((...)))))))))))......))....))...(((((........)))))]]((((....(((((...(((((((....)))))))..((((....)))...(...((((((...(((((((((((((((((((((((...{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((.)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(..(((.....((((....)))).....))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.(((((((((.(((((((((())))))))))...(((((.....((((..((....(())....))..............(((((((((())))))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..b.))..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}..)))))..)).))...))))...)))).((((...((((.....a.......))))...))))..)))...).)))))).(((((((..((((....(((.........((((...((((.))))..))))........)))...(((..(((.....((((((((..........))))).)))....)))..)))..............))))..).)))))).(((((.(..(.......)..)....((.(((((((.((.....((((.(..(((((.)))))..)))))....))....)))).))).))..))))).. Structure of the rabbit 80S ribosome stalled on a 2-TMD rhodopsin intermediate in complex with Sec61-RAMP4; 28S rRNA 8rjb q 76 2.69243 RF00005 URS0000868530_9823 38896445,28710774,29872003,34783343 0030533 9823 gucuccguaguguagcgguuaucacguucgccuaacacgcgaaagguccucgguucgaaaccgggcggaaacacca <<.<<<<..<<<..........>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>.>>.... ((.((((..(((.....[....))).(((((.......))))).....(((((..]....))))))))).)).... Structure of the rabbit 80S ribosome stalled on a 2-TMD rhodopsin intermediate in complex with Sec61-RAMP4; P-site tRNA 8rjb u 120 2.69243 RF00001 URS000002B0D5_9986 38896445,28710774,29872003,34783343 0003735 0005840 9986 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. Structure of the rabbit 80S ribosome stalled on a 2-TMD rhodopsin intermediate in complex with Sec61-RAMP4; 5S rRNA 8rjb v 156 2.69243 RF00002,RF02540 URS00004B2C76_9986 38896445,28710774,29872003,34783343 0003735 0005840 9986 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<<<<....>>>>.....<.<<<......>>.............>>>..>...>>>....<<....>><<<<<<<<<.....>>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))(((((((((.....))))))))).................... Structure of the rabbit 80S ribosome stalled on a 2-TMD rhodopsin intermediate in complex with Sec61-RAMP4; 5.8S rRNA 8rjc K 3543 2.90061 RF02543 URS0000A7632C_9986 38896445,28710774,29872003,34783343 0003735 0005840 9986 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggaaauguggcguacggaagacccacuccccggcgccggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcgcgguccggccgugccggcggggcggaucucccgcucccgucggcgggggaccgccccccggccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggccccggcggggaagguggcccgggggccccggguguuacagccccgccccggcagcagcagcucgccgaaucccggggccgagggagcgagacccgugcgccgcgcucuccccccucgggggggccgggccaccccucccacggcgcgaccgcuggggcggacuguccagugcgccccgggcgggucgcgccgucgggcccggggggccacgcgucccccgcgagcgcacggggucggcggcgaugucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcuacgaaagccgccguggcgcaaugaaggugaaggccggcggcgcgccgccggccgaggugggaucccgaggccuuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcgaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccaaaguuucccucaggauagcuggcgcucuccgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcugguguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggaugguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgcuggcagucggcagagcgagaaagagaguggcgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucagccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcuggcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacguuuuuucacugacccggugaggcgggggggcgagccgggcucucgcuucuggcgccaagcgcccggccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauagcgccggagccucgguuggccucggauagccggucccccgccgggguccggugcggagagcccuucgucccgggaaacggggcggccggaaagggggccgcccucucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcugcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..[[[..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>>..<<<<<<<<<....<<<<<<<<..<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>...>>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<......>>>..................................<<<<<<<<..<<<.<....<<<<<<<<.<<<.....<<<<<<<<<<....<<<<<<<.<<<<<.<<<<<<<.<<<<<<<<<......>>>>>>>>>>>>>>>>>>>>>>>>>...>>>.>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<<<<<<<<<<<<<<<<<...<<..<<<..<<<<<<<......<<<<<<<<.>>>>>>>>.......>>>>>>>..>>>.........>>>>>>..>>>>>>>>>>>.....<<.......>>.........<...<<<<<<..>>>>>>...<.<<..<<<.<<<<<<<<<<<<<<<<<<<<<<<.<<<<..>>>>.>>>>>>.>>>.>>>>>>>>>>>.>>>...>>>>>.>................>........>>>.>>>>>....>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<.....>>>>.....>>>...<<....>>...<<<<<<<<<<..>>>>>>>>>>..<<<<<...<<<..<<<...(((.[[.>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<...<<<.<<<<<<<<<...<<<....<<<..<.<<<..<<<<<<.<.....>.>>>>>>>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.........>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<...<<...................>>.......................>.>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<....................]].)))............>>>>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<<<<<...>>>>>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<...<<<<<<<....>>>>>>>...<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..{{{..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<...............>>>>><<.<<<<<<<<<<<.>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<<.<<<<<<<<<..>>>>>>>>>...<<<<<.....<<<<..<<....<<>>....>>..............<<<<<<<<<..>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>><<<<....>>>>>>)))]......((((((..(((..>>>>>>.)))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]].....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<}}}.>>>>>..>>.>>...>>>>...>>>><<<<....<<<<<...........>>>>>....>>>>.>>>...>.>>>>>>.<<<<<<<..<<<<....<<<........<<<<<..<<<<<.>>>>>.>>>>>.......>>>...<<<..<<<<....<<<<<<<<..........>>>>>.>>>...>>>>..>>>..............>>>>..>.>>>>>>.<<<<<.<.............>....<<.<<<<<<<.<<.....<<<<.<..<<<<<.>>>>>..>>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..(((((((((((.....)))))).))))....))))....(((((((((....((((((((..((((((((..({((((......)))))....[[(...).(((....}]])))...).)))))))...))))))))...)))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....((((((((((.(..(((((.(.(((((.(((((((.((.((((((......)))))).))))))))))))))).))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((..(((((((......((((((((.)))))))).......)))))))..))).........))))))..))))))))))).....((.....{.)).........(.(.((((((()))))))...(.((..(((.((((((((((((((.((((((((.((((..)))).)))))).))..))))))))))).)))...))))).)............[.).)........))).)))))...)))))...)))))))).<((((........))))((((((....(((((((((((((..(((..(((((.....))))..)..)))...((....))...((((((((((()))))))))))..(((((...(((..(((]..[[[.[[[)))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((........)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((...(((.((((((((....(((....(((..(.(((...(((((.(.....).))))).))).)..)))..)).)....))))))...(((((((((.(......))))))))))....))))))))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[.....(.(((((......(..........(((.((((((((((.....A....(...((....(..........)...))......(..............).).......)))))))))))))..........]]].)....)))))).)))...)))))))((((((.(((........}.........].]].]]]............)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...((..(.(((....))).....)....((.(((((((((...)))))))))))......))....))...(((((........)))))]]((((....(((((...(((((((....)))))))..((((....)))...(...((((((...(((((((((((((((((((((((...{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((.)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.(((((((((.(((((((((())))))))))...(((((.....((((..((....(())....))..............(((((((((())))))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))....))..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}..)))))..)).))...))))...)))).((((...((((.....a.......))))...))))..)))...).)))))).(((((((..((((....(((.........((((...((((.))))..))))........)))...(((..(((.....((((((((..........))))).)))....)))..)))..............))))..).)))))).(((((.(..(.......)..)....((.(((((((.((.....((((.(..(((((.)))))..)))))....))....)))).))).))..))))).. Structure of the rabbit 80S ribosome stalled on a 2-TMD rhodopsin intermediate in complex with Sec61-TRAP, open conformation 1; 28S rRNA 8rjc q 76 2.90061 RF00005 URS0000868530_9823 38896445,28710774,29872003,34783343 0030533 9823 gucuccguaguguagcgguuaucacguucgccuaacacgcgaaagguccucgguucgaaaccgggcggaaacacca <<.<<<<..<<<..........>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>.>>.... ((.((((..(((.....[....))).(((((.......))))).....(((((..]....))))))))).)).... Structure of the rabbit 80S ribosome stalled on a 2-TMD rhodopsin intermediate in complex with Sec61-TRAP, open conformation 1; P-site tRNA 8rjc u 120 2.90061 RF00001 URS000002B0D5_9986 38896445,28710774,29872003,34783343 0003735 0005840 9986 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. Structure of the rabbit 80S ribosome stalled on a 2-TMD rhodopsin intermediate in complex with Sec61-TRAP, open conformation 1; 5S rRNA 8rjc v 156 2.90061 RF00002,RF02540 URS00004B2C76_9986 38896445,28710774,29872003,34783343 0003735 0005840 9986 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<<<<....>>>>.....<.<<<......>>.............>>>..>...>>>....<<....>><<<<<<<<<.....>>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))(((((((((.....))))))))).................... Structure of the rabbit 80S ribosome stalled on a 2-TMD rhodopsin intermediate in complex with Sec61-TRAP, open conformation 1; 5.8S rRNA 8rjd K 3543 2.78574 RF02543 URS0000A7632C_9986 38896445,28710774,29872003,34783343 0003735 0005840 9986 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggaaauguggcguacggaagacccacuccccggcgccggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcgcgguccggccgugccggcggggcggaucucccgcucccgucggcgggggaccgccccccggccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggccccggcggggaagguggcccgggggccccggguguuacagccccgccccggcagcagcagcucgccgaaucccggggccgagggagcgagacccgugcgccgcgcucuccccccucgggggggccgggccaccccucccacggcgcgaccgcuggggcggacuguccagugcgccccgggcgggucgcgccgucgggcccggggggccacgcgucccccgcgagcgcacggggucggcggcgaugucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcuacgaaagccgccguggcgcaaugaaggugaaggccggcggcgcgccgccggccgaggugggaucccgaggccuuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcgaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccaaaguuucccucaggauagcuggcgcucuccgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcugguguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggaugguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgcuggcagucggcagagcgagaaagagaguggcgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucagccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcuggcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacguuuuuucacugacccggugaggcgggggggcgagccgggcucucgcuucuggcgccaagcgcccggccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauagcgccggagccucgguuggccucggauagccggucccccgccgggguccggugcggagagcccuucgucccgggaaacggggcggccggaaagggggccgcccucucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcugcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<...<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>...<<<<<<<<<....<<<<<<<<..<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>...>>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<......>>>..................................<<<<<<<<..<<<.<....<<<<<<<<.<<<.....<<<<<<<<<<....<<<<<<<.<<<<<.<<<<<<<.<<<<<<<<<......>>>>>>>>>>>>>>>>>>>>>>>>>...>>>.>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<<<<<<<<<<<<<<<<<...<<..<<<..<<<<<<<......<<<<<<<<.>>>>>>>>.......>>>>>>>..>>>.........>>>>>>..>>>>>>>>>>>.....<<.....{.>>.........<...<<<<<<..>>>>>>...<.<<..<<<.<<<<<<<<<<<<<<<<<<<<<<<.<<<<..>>>>.>>>>>>.>>>.>>>>>>>>>>>.>>>...>>>>>.>................>........>>>.>>>>>....>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<.....>>>>.....>>>...<<....>>...<<<<<<<<<<..>>>>>>>>>>..<<<<<...<<<..<<<...(((.[[.>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<...<<<.<<<<<<<<<...<<<....<<<..<.<<<..<<<<<<.<.....>.>>>>>>>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<...<<....<..........>...>>.......................>.>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<........}...........]].)))............>>>>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<<<<<...>>>>>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<...<<<<<<<....>>>>>>>...<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>.>>>>....<<<<.....<<<<<<<.<<...............<<<<<.....<..>......>>>>><<.<<<<<<<<<<<.>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<<<..>>>>>>>>>...<<<<<.....<<<<..<<.<..<<>>..>.>>..............<<<<<<<<<..>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>><<<<....>>>>>>)))].....<<<<<<<..<<<..)))))).>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<]]].>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.<<<<<<<..<<<<....<<<........<<<<<..<<<<<.>>>>>.>>>>>.......>>>...<<<..<<<<....<<<<<<<<..........>>>>>.>>>...>>>>..>>>..............>>>>..>.>>>>>>.<<<<<.<.............>....<<.<<<<<<<.<<.....<<<<.<..<<<<<.>>>>>..>>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..(((((((((((.....)))))).))))....))))....(((((((((....((((((((..((((((((..({((((......)))))....[[(...).(((....}]])))...).)))))))...))))))))...)))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....((((((((((.(..(((((((.(((((.(((((((.((.((((((......)))))).))))))))))))))))))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((..(((((((......((((((((.)))))))).......)))))))..))).........))))))..))))))))))).....((.....{.)).........(.(.((((((()))))))...(.((..(((.((((((((((((((.(.((((((.((((..)))).))))))..)..))))))))))).)))...))))).)............[.).)........))).)))))...)))))...)))))))).<((((........))))((((((..(.(((((((((((((..(((..(((((.....))))..)..)))...((....))...((((((((((..))))))))))..(((((...(((..(((]..[[[.[[[)))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......B)))).)))..).))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((.(((((((...(((.((((((((....(((....(((..(.(((...(((((.(.....).))))).))).)..)))..)).)....))))))...(((((((((.(......))))))))))....))))))))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[.....(.(((((......(..........(((.((((((((((.....A.(..(...((....(..........)...))......(..............).)....)..)))))))))))))..........]]].)....)))))).)))...)))))))((((((.(((........}.........].]].]]]............)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...((..(.(((....))).....)....((.(((((((((...)))))))))))......))....))...(((((........)))))]]((((....(((((...(((((((....)))))))..((((....)))...(...((((((...(((((((((((((((((((((((...{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((.)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.(((((((((.(((((((((())))))))))...(((((.....((((..((....(())....))..............(((((((((())))))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..b.))..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}..)))))..)).))...))))...)))).((((...((((.....a.......))))...))))..)))...).)))))).(((((((..((((....(((.........((((...((((.))))..))))........)))...(((..(((.....((((((((..........))))).)))....)))..)))..............))))..).)))))).(((((.(..(.......)..)....((.(((((((.((.....((((.(..(((((.)))))..)))))....))....)))).))).))..))))).. Structure of the rabbit 80S ribosome stalled on a 2-TMD rhodopsin intermediate in complex with Sec61-TRAP, open conformation 2; 28S rRNA 8rjd q 76 2.78574 RF00005 URS0000868530_9823 38896445,28710774,29872003,34783343 0030533 9823 gucuccguaguguagcgguuaucacguucgccuaacacgcgaaagguccucgguucgaaaccgggcggaaacacca <<.<<<<..<<<..........>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>.>>.... ((.((((..(((.....[....))).(((((.......))))).....(((((..]....))))))))).)).... Structure of the rabbit 80S ribosome stalled on a 2-TMD rhodopsin intermediate in complex with Sec61-TRAP, open conformation 2; P-site tRNA 8rjd u 120 2.78574 RF00001 URS000002B0D5_9986 38896445,28710774,29872003,34783343 0003735 0005840 9986 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. Structure of the rabbit 80S ribosome stalled on a 2-TMD rhodopsin intermediate in complex with Sec61-TRAP, open conformation 2; 5S rRNA 8rjd v 156 2.78574 RF00002,RF02540 URS00004B2C76_9986 38896445,28710774,29872003,34783343 0003735 0005840 9986 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<<<<....>>>>.....<.<<<......>>.............>>>..>...>>>....<<....>><<<<<<<<<.....>>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))(((((((((.....))))))))).................... Structure of the rabbit 80S ribosome stalled on a 2-TMD rhodopsin intermediate in complex with Sec61-TRAP, open conformation 2; 5.8S rRNA 8rl2 L5 3382 2.84 RF02540,RF02543,RF02541 29872004 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccgccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcggcccggcggaucuuucccgcgcgggggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucgggggcccccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggaggucgccgcgcucuccccccucccggcgcgccggggggggccgggccaccccucgggggaggccacgcgcgcgucccgggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccgucgaaacacggaccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuuccggauagcuggcgcucuccgcaguuuuauccgguaaagcgaaugauuagauauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggagcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcuggcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacaugagugaucguuuuuucacugacccggugaggcgggggggcgagccccgaggggcucucgcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccagguggggaguuuggggcgguacaccugugcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacccuucugaccuuuuggguuuuaagcaggaggaaaguuaccacagggauggcuuguggcggccaagcgagcgacgucgcuuuuugauccuucgacggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacguagcuggguagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccggucccccgccgggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<..>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<<...<<<<<<<<<<<...>>>>>>>.>>>>.....>>>>>..<<<<<<<<<<.<<<<<<<<........<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>...>>>>>>>>..>>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<......>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<<<..<<<<<<<.<<<<..<<....<<<<.<<<..<<<<..>>>>>>>>>>>>>..>>>>>>>>...>>>>>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<<<<<<<<<<<<<<<<<...<<..<<<.<<.<<<<......<<<<<<<<..>>>>>>>>.......>>>>>>.>>>........>>>>>>..>>>>>>>>>>>............<<<<<<.<<<<<<<...<<....>>.>>>>>>>.<<<<<<.<<<<..>>>>..>>>>.>>..<<<<<<<..>>>>>.>>....>>>>>>.....>>>.>>>>>...>>>>>...>>>>>>>>..<<<<......>>>><<<<<<...<<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<......>>>>>>>..<<<<<...<<<..<<<...>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>>.<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<......<<..>>..<<.<<<<<<<...<<<.<<<<<<<<<...<<<....<<<..........>>>..>.>>...>>>>>>>...<<<<<<<<<.........>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<...........>>>>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<...<...>...>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<.<<<<<..<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<...............<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<.>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>.......<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<.........>>>>>.........<<<.>>>.....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<........<<<<<<..<<<<..<<<<<.<<<<<<<<<.<<<<<<<<<<<<.<.>.>>.>>>>>>>>>>...<<<<<.....<<<<.....<..............>................<<<<<<<<<<<.....>>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<<<<.<<<<<<<..>>>>>>>.>>..<<<<<<<...<<<<<<.......>>>>>>.....<<......>>....>>>>>>>.....<<<.<.<<<.....>>>.>>>>.<<<<....>>>>.>>>>...<<<<<<<..<<<..)))))).>>>>>>>>>>..>>>>...>>>>>>.........<<<<<<...<<..>>...>>>>>>..............<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>..>>>>....<<<<<<<....>>>.>>>>........>>>.>>>>>.....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<]]].>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.....<<<<<<<.<<..<<<<....<<<........<<<<<.<<<<....>>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>..............>>>>..>>>>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<.<..<<<<<......>>>>>..>>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(..).......)))).).........((....))...((((......((.....)).....))))...((((...(((..((((((((((((...))))))).))))....))))....((((((((((.((((((((...(....((((((((..({((((......)))))....[[(...).(((....}]])))...).))))))))..))))))))..))))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....(((((((((((..(((((((...((..((....((((.((...((.(..).)).))))))))..))..))))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((....((((......(.((((((())))))).).......))))...)))........))))))..)))))))))))............((((((.((((((.....(.....)..)))))).((((((.((((..))))..)))).))..(((((((()))))).))....)))))).....))).)))))...)))))...))))))))..((((......))))((((((..(.(((((((((((((..(((..(((((........))))..)..)))...((....))...(((((((......)))))))..(((((...(((..(((...)))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)A)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)[.))))))......).))).((((((......((()))..((.(((((((...(((.((((((((....(((....(((..(.().)..)))..)).)....))))))...(((((((((.(......))))))))))....))))))))))))..))..((((.(.(((.....))).).))))....(((......)))...(((((((...((([[[...(.(.(((((......(..<.....(((.((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((...........)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...((....(((....)))..........((.((((....(....)...))))))......))....))...(((((........)))))]]((((.(((((...(((((((....)))))))..((((....)))...(...((((((...(((((((((((((((((((((((..{{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....(((((((.......))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((.)))))..)))))).))(...).......(((((((((.a.((.........))...(((((((....((((.....))))......))))))).].....(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........))))).........(((.))).....)).))))))).)..))).)))))))..))))))....)).[..(((((......].)))))....(((((..((((.......((((((](((((..(((((.(.(((((((.((((((((((.(.(.).)..))))))))))...(((((.....((((.....((............))................((((((((((.......))))))))))..))))..)))))....))))))).)..)))))...((((((.(((((((..))))))).))..(((((((.(.((((((.......))))))...).((......))....)))))))......((...(((.....)))..))..((((....)))).))))...(((((((..(((..]]]]]].))))))))))..)))).).))))))...>.....((((((...((..))...))))))...............(((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)..))).....(((((((....))).))))..>..)..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}}.)))))..)).))...))))...)))).((((...((((.....}.......))))...))))..)))...).)))))).....(((((((.((..((((.(..(((........(((((.((((.(.))))).))))).......)))...(((..((((....(((..(((((((......)))))).))))...))))..)))...........)..))))..)))))))))(((((.(..(.......)..)....((.(((((((.((.....((((.(..(((((......)))))..)))))....))....)))).))).))..))))).. Human pre-60S - State 5; 28S rRNA 8rl2 L8 156 2.84 RF00002,RF02540 29872004 0003735 0005840 9606 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<<<<....>>>>.....<.<<<......>>.............>>>..>...>>>....<<....>><<<<<<<<<.....>>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))(((((((((.....))))))))).................... Human pre-60S - State 5; 5.8S rRNA 8rm5 Z 15 6.9 38778104 9606 gaugucauacuuauc ............... ............... Cryo-EM structure of the cross-exon pre-B+5'ssLNG+ATPyS complex; pre-mRNA 8rm5 2 98 6.9 RF00004 38778104 0045131 0000348 0005686 9606 cgcuucucggccaaguguaguaucuguucuuaucaguuuaauaucugauggauuuuuggagcaucgaccugguauugcaguaccuccaggaacggugc ................................<<<<........>>>>............<<<<<<.<<<<<.............>>>>>..>>>>>> ...............................(.(((........))).)...........((((((.(((((.............)))))..)))))) Cryo-EM structure of the cross-exon pre-B+5'ssLNG+ATPyS complex; U2 snRNA 8rm5 z 18 6.9 38778104 9606 aagguaaguaucguucca .................. .................. Cryo-EM structure of the cross-exon pre-B+5'ssLNG+ATPyS complex; 5'SS oligo 8rm5 5 112 6.9 RF00020 38778104 0000244,0000353 0005682,0046540 9606 acucugguuucucuucagaucgcauaaaucuuucgccuuuuacuaaagauuuccguggagaggaacaacucugagucuuccaauuuuuugaggccuugcuuuggcaaggcua .<<<...<<<<<<<<<<........<<<<<<<<...........>>>>>>>>...>>>>>>>>>>.......>>>................<<<<<<<<....>>>>>>>>. ..((...((((((((((...((...((((((((.(.......).)))))))).)))))))))))).......)).................((((((((....)))))))). Cryo-EM structure of the cross-exon pre-B+5'ssLNG+ATPyS complex; U5 snRNA 8rm5 4 110 6.9 RF00015 38778104 0017070 0000244,0000353 0005687,0046540 9606 agcuuugcgcaguggcaguaucguagccaaugaggucuauccgaggcgcgauuauugcuaaugccgugacgacuagucggcacuggcaauuuuugacagucucgagacug ...................<<<<<.<<<.....<<.....>>..>>>>>>>>..........<<<<<<.<<<<..>>>>.>>>.>>>.........<<<<<<<>>>>>>> ...................(((((.(((.....((.....))..))))))))..........((((((.((((())))).))).))).........((((((())))))) Cryo-EM structure of the cross-exon pre-B+5'ssLNG+ATPyS complex; U4 snRNA 8rm5 6 64 6.9 RF00026 38778104 0030621 0000244,0000353 0005688,0046540 9606 uggaacgauacagagaagauuagcauggccccugcgcaaggaugacauucgugaagcguauuuu ................................................................ ................................................................ Cryo-EM structure of the cross-exon pre-B+5'ssLNG+ATPyS complex; U6 snRNA 8ro0 2 61 2.9 RF00004 38925148 0045131 0000348 0005686 6239 cgcuucuucggcuuagcuaagaucnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn ............................................................. ............................................................. Structure of the C. elegans Intron Lariat Spliceosome primed for disassembly (ILS'); U2 snRNA 8ro0 5 111 2.9 RF00020 38925148 0000244,0000353 0005682,0046540 6239 acucugguuccucugcauuuaaccgugaaaaucuuucgccuuuuacuaaagauuuccgugcaaaggagcauacauugaguaaauuuuuggaguccccucgaaagagcggga ......<<<<<<.<<<<...........<<<<<<<<...........>>>>>>>>...>>>>.>>>>>>.......................<<<<<<<....>>>.>>>> ......((((((.((((.......(...((((((((.(.......).)))))))).).)))).)))))).......................(((((((....))).)))) Structure of the C. elegans Intron Lariat Spliceosome primed for disassembly (ILS'); U5 snRNA 8ro0 6 90 2.9 RF00026 38925148 0030621 0000244,0000353 0005688,0046540 6239 guucuuccgagaacauauacuaaaauuggaacaauacagagaagauuagcauggccccugcgcaaggaugacacgcaaauucgugaagcg <<<<<<..>>>>>>.....................................<<...<<<.....>>>....>>................. ((((((..)))))).....................................((..((((.....)))..).))................. Structure of the C. elegans Intron Lariat Spliceosome primed for disassembly (ILS'); U6 snRNA 8ro0 In 19 2.9 38925148 6239 nnnnnnnnnnnnnnnnnnn ................... ................... Structure of the C. elegans Intron Lariat Spliceosome primed for disassembly (ILS'); Intron lariat RNA 8ro1 2 76 3.0 RF00004 38925148 0045131 0000348 0005686 6239 aucgcuucuucggcuuagcuaagaucaaaguguaguaucnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn ............................................................................ ............................................................................ Structure of the C. elegans Intron Lariat Spliceosome double-primed for disassembly (ILS''); U2 snRNA 8ro1 5 111 3.0 RF00020 38925148 0000244,0000353 0005682,0046540 6239 acucugguuccucugcauuuaaccgugaaaaucuuucgccuuuuacuaaagauuuccgugcaaaggagcauacauugaguaaauuuuuggaguccccucgagagagcggga ......<<<<<<.<<<<...........<<<<<<<<...........>>>>>>>>...>>>>.>>>>>>.......................<<<<<<<....>>>.>>>> ......(.((((.((((.......(...((((((((.(.......).)))))))).).)))).)))).).......................(((((((....))).)))) Structure of the C. elegans Intron Lariat Spliceosome double-primed for disassembly (ILS''); U5 snRNA 8ro1 6 101 3.0 RF00026 38925148 0030621 0000244,0000353 0005688,0046540 6239 guucuuccgagaacauauacuaaaauuggaacaauacagagaagauuagcauggccccugcgcaaggaugacacgcaaauucgugaagcguuccaaauuuu <<<<<<..>>>>>>.....................................<<...<<<.....>>>....>>............................ ((((((..)))))).....................................((..((((.....)))..).))............................ Structure of the C. elegans Intron Lariat Spliceosome double-primed for disassembly (ILS''); U6 snRNA 8ro1 IN 33 3.0 38925148 6239 gunnnnnnnnnnnnnnnnnnnnnnnnnnnannn ................................. ................................. Structure of the C. elegans Intron Lariat Spliceosome double-primed for disassembly (ILS''); Intron lariat RNA 8ro2 2 39 3.5 RF00004 38925148 0045131 0000348 0005686 9606 aucgcuucucggccuuuuggcuaagaucaaguguaguau ....................................... ....................................... Integrative Structure of the human intron lariat Spliceosome (ILS''); U2 snRNA 8ro2 6 97 3.5 RF00026 38925148 0030621 0000244,0000353 0005688,0046540 9606 gugcucgcuucggcagcacauauacuaaaauuggaacgauacagagaagauuagcauggccccugcgcaaggaugacacgcaaauucgugaagcguu <<<<<.<<....>>>>>>>.....................................<<...<<<.....>>>....>>................... (((((.((....))))))).....................................((..((((.....)))..).))................... Integrative Structure of the human intron lariat Spliceosome (ILS''); U6 snRNA 8ro2 5 92 3.5 RF00020 38925148 0000244,0000353 0005682,0046540 9606 guuucucuucagaucgcauaaaucuuucgccuuuuacuaaagauuuccguggagaggaacaccaauuuuuugagccuugccuuggcaaggcu <<<<<<<<<<<........<<<<<<<<.<.......>.>>>>>>>>...>>>>>>>>>>>............<<<<<<<<....>>>>>>>> (((((((((((...((...((((((((.(.......).)))))))).))))))))))))).............(((((((....))))))). Integrative Structure of the human intron lariat Spliceosome (ILS''); U5 snRNA 8ro2 IN 41 3.5 38925148 9606 nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn ......................................... ......................................... Integrative Structure of the human intron lariat Spliceosome (ILS''); INTRON 8rpy A 2900 2.64 RF02541 38730238 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugucgaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccgggagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<<..>>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<.<..>.>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<....<<.........>>....>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<.<<....>>.>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<<.<<....>>..>>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<.<<<<<.............<<<..<<<......<<..<<<......>>>..>>...>>>............>>>....>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>........<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>.....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[......(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((((..)))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(.((........))..)...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((.((..(((.....{.((.((.(.......................)........(((......)))..)).))...)))..)).)).))...........]]].)...))))))))))...)))))))((((((.(......).))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((((((((.(..(................(...(........(..(((......)))..).....).............).......)...)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Escherichia coli 50S subunit in complex with the antimicrobial peptide Api137; 23S ribosomal RNA 8rpy B 120 2.64 RF00001 38730238 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Escherichia coli 50S subunit in complex with the antimicrobial peptide Api137; 5S ribosomal RNA 8rpz A 2900 2.44 RF02541 38730238 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugucgaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccgggagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<<..>>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<......>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<.........>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<.<<....>>.>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<..<<....>>...>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<.<<<<<...........<.<<<..<<<......<<..<<<......>>>..>>...>>>............>>>..>.>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[......(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((((..)))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(.((........))..)...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{..((((.(.......................)........(((......)))..))))....)))..))))).))...........]]].)...))))))))))...)))))))((((((.(......).))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((.((.(..(................(............(..(((......)))..)...................).......)...))).)))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Escherichia coli 50S subunit in complex with the antimicrobial peptide Api88 - conformation I; 23S ribosomal RNA 8rpz B 120 2.44 RF00001 38730238 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Escherichia coli 50S subunit in complex with the antimicrobial peptide Api88 - conformation I; 5S ribosomal RNA 8rq0 A 2900 2.44 RF02541 38730238 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugucgaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccgggagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<<..>>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<......>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<.........>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<.<<....>>.>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<..<<....>>...>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<.<<<<<...........<.<<<..<<<......<<..<<<......>>>..>>...>>>............>>>..>.>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[......(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((((..)))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(.((........))..)...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{..((((.(.......................)........(((......)))..))))....)))..))))).))...........]]].)...))))))))))...)))))))((((((.(......).))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((.((.(..(................(............(..(((......)))..)...................).......)...))).)))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Escherichia coli 50S subunit in complex with the antimicrobial peptide Api88 - conformation II; 23S ribosomal RNA 8rq0 B 120 2.44 RF00001 38730238 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Escherichia coli 50S subunit in complex with the antimicrobial peptide Api88 - conformation II; 5S ribosomal RNA 8rq2 A 2900 2.44 RF02541 38730238 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugucgaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccgggagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<<..>>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<......>>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<.........>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<.<<....>>.>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<..<<....>>...>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<.<<<<<...........<.<<<..<<<......<<..<<<......>>>..>>...>>>............>>>..>.>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[......(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((((..)))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(.((........))..)...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{..((((.(.......................)........(((......)))..))))....)))..))))).))...........]]].)...))))))))))...)))))))((((((.(......).))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((.((.(..(................(............(..(((......)))..)...................).......)...))).)))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Escherichia coli 50S subunit in complex with the antimicrobial peptide Api88 - conformation III; 23S ribosomal RNA 8rq2 B 120 2.44 RF00001 38730238 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Escherichia coli 50S subunit in complex with the antimicrobial peptide Api88 - conformation III; 5S ribosomal RNA 8ruh A 390 4.55 RF02001,RF01998 URS000080DF32_182710 38898052 0000373 182710 ugugcccggcaugggugcagucuauagggugagagucccgaacugugaaggcagaaguaacaguuagccuaacgcaaggguguccguggcgacauggaaucugaaggaagcggacggcaaaccuucggucugaggaacacgaacuucauaugaggcuagguaucaauggaugaguuugcauaacaaaacaaaguccuuucugccaaaguugguacagaguaaaugaagcagauugaugaagggaaagacugcauucuuacccggggaggucuggaaacagaagucagcagaagucauaguacccuguucgcaggggaaggacggaacaaguauggcguucgcgccuaagcuugaaccgccguauaccgaacgguacguacgguggugugg ....<<<<<...<<<<<<<<<<<...<<<.......>>>..<<<<<...(((((((...>>>>>..<<<...<<<..<<<<.<<<<<<....>>>>>>>>>>.......>>>...>>>...<<<<<<<<<<<...........<<<<<......<<<..<<<<<<<<<<<<..<<<<........>>>>...>>>>.)))))))...>>>>>>>>..>>>...>>>>>>>>>>...>>>>>>...>>>>>>>>>>>....>>>>>....<<<<....>>>>...........<<<......<<<<<....>>>>>....>>>....<<<<<..<<<<....>>>>...>>>>>.<<<<<<<<<<<<<....>>>..>>>>>>>>>>.... .[<.((((({..(((((((((((...(((.......)))..(((((...[[[[[[[...)))))..(((...(((..((((.((((((....))))))))))...>}..)))...)))...(((((((((((.(.....)...(((((.....[(((..(.((((((((((..((((.]......))))...)))).]]]]]]]...)))))).)..)))...))))))))))...))))))...)))))))))))...])))))(...((((....))))...).......(((.(....(((........)))...))))....(((((..((((....))))...))))).(((((((((((((....)))..)))))))))).... Structure of Oceanobacillus iheyensis group II intron in the presence of K+, Mg2+ and 5'-exon; Domains 1-5 8rw1 2 1798 3.35 RF01960,RF02542,RF01959,RF00177 39193907 0003735 0005840 284590 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacauggauaucugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacuccuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaacuggagggcaagucuggugccagcagccgcgguaauuccagcuccaguagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggucugguuguccgguccgacuuuaugucgcgcacugguuuucaaccggaucuuuccuucuggcuaaccuguacuccuugugggugcaggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcgaaagcucgaauauauuagcauggaauaauggaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauacngucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuucuuaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacncaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaggguugcuggcacuugccgguugacucuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacangucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgaguacaaccuuggccgagaggucuggguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacnagnaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgnccgucgcuaguaccgauugaauggcuuagugaggccucaggauuugcuuagagaagggggcaacuccaucucagagcgaagaaucuggucaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguagguganccugcggaaggaucauua ...<<<<<...[[[[>>>>>[[[[.((((((................[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[..{{..{{....[[[................<<.....<<.<<<.....>>>.>>......>>........<<<<<..<<....>>..>>>>>[...((((((......<<<<<<<<<<<....>>>....<<......>>)))))).....]...<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>...............<<<<<<<<<.<.......>..>>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]].........[[[{{.......{{...[[[.{{....<<<<<<<<<<<.<<<<..<<<.......>>>....>>>>....>>>>>>>>>>>....<<<<<<....<....<<<.......>>>....>....>>>>>>...<<<<<.<<.......<<...<.......>..<<<....>>>....>>......>>.>>..>>>.........[[[..((((((((....>>>>>>>>.)))))))).]]].....}}....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.]]].<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<<<<<<<<....<<<.<<<<......>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<<<<<<<<....>>>>>>.>>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>...>.>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<<.<<<<....>>>>.>>>....>>.......>>>>>>>......<....<<<<<<..........>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<..<...<<<<<<..<...................>...>>>>>>...>..>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))((.(.((.(((...(.(....(.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((............{...((.....((.(((.....))).))......))........(((((..((....))..)))))(.(.((((((......[[[.[[[.(((....))).....(......).)))))).)...).(}((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.(((......)))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).)))))......).).....((.((((.(..((....))..).))))..))....(.(((.(...........)).))......)..(((.([[....(.((((.....((..]])).......)))))).)))..))).))).))..{......((({....(.(.((...(((.((....(((((((((((.((.(..(((.......)))....).))....)))))))))))......(.((.........(((.......))).........)).).....((.((.((.......(...((.......)).(((....))).....)......)).))...)).........(((..(....(((.....]].]]]].)))....).))).....))....((..((..(...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)..))...))...)))...)).)....((((..........((.(.........).)).......))))......<...(((.((.(((...(((((((.((..........)))))))))...)))...((...}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((..(((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....((..(.(((....)))..(.((......)))....)..))....(((((.((..((((..((((((.(.(((....))).)..))))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))..))).(...(((((((......((.....(((.((((....)))).)))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(..((((.((.(((..((((..(...((.(((..(....................)..))).))...)..))))..))).)).)))).)..)).))))...).))...)..)..(((((((((....)))))))))>........ Structure of a yeast 48S-AUC preinitiation complex in closed conformation; 18S ribosomal RNA 8rw1 3 26 3.35 39193907 28985 cucuaacuauaaaaaucucucuucuc .......................... .......................... Structure of a yeast 48S-AUC preinitiation complex in closed conformation; mRNA (5'-R(P*AP*AP*U)-3') 8rw1 1 75 3.35 RF00005 39193907 0030533 559292 agcgccgunncgcagnggaagcgcncagggcucaunacccugaunnnnucggaucgnaaccgngcggcgcuacca <<<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((....[..)))).(((((.......))))).....(((((..]....)))))))))))).... Structure of a yeast 48S-AUC preinitiation complex in closed conformation; Met-tRNAi 8rwg A 2805 2.46 RF02540,RF02541,RF02543,RF00002 0003735 0005840 208964 gucaagugaagaagcgcauacgguggaugccuuggcagucagaggcgaugaaagacgugguagccugcgaaaagcuucggggagucggcaaacagacuuugauccggagaucucugaaugggggaacccaccuaggauaaccuagguaucuuguacugaauccauaggugcaagaggcgaaccaggggaacugaaacaucuaaguacccugaggaaaagaaaucaaccgagauucccuuaguaguggcgagcgaacggggauuagcccuuaagcuucauugauuuuagcggaacgcucuggaaagugcggccauagugggugauagccccguacgcgaaaggaucuuugaagugaaaucgaguaggacggagcacgagaaacuuugucugaacauggggggaccauccuccaaggcuaaauacuacugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggagaggggagugaaauagaaccugaaaccguaugcguacaagcagugggagccuacuuguuaggugacugcguaccuuuuguauaaugggucagcgacuuauauucaguggcaagcuuaaccguauaggguaggcguagcgaaagcgagucuuaauagggcguuuagucgcuggguauagacccgaaaccgggcgaucuauccaugagcagguugaagguuagguaacacugacuggaggaccgaacccacucccguugaaaagguaggggaugacuuguggaucggagugaaaggcuaaucaagcucggagauagcugguucuccucgaaagcuauuuagguagcgccucauguaucacucugggggguagagcacuguuucggcuagggggucacuuaccaaaccgaugcaaacuccgaauacccagaagugccgagcaugggagacacacggcgggugcuaacguccgucgugaaaagggaaacaacccagaccgccagcuaaggucccaaaguugugguuaagugguaaacgaugugggaaggcuuagacagcuaggagguuggcuuagaagcagccacccuuuaaagaaagcguaauagcucacuagucgagucggccugcgcggaagauguaacggggcucaaaccacacaccgaagcugcgggugucacguaagugacgcgguagaggagcguucuguaagccugugaaggugaguugagaagcuugcuggagguaucagaagugcgaaugcugacaugaguaacgacaaugggugugaaaaacacccacgccgaaagaccaaggguuccugcgcaacguuaaucgacgcaggguuagucgguuccuaaggcgaggcugaaaagcguagucgaugggaaacagguuaauauuccuguacuucugguuacugcgauggagggacggagaaggcuaggccagcuuggcguugguuguccaaguuuaaggugguaggcugaaaucuuagguaaauccgggguuucaaggccgagagcugaugacgagucgucuuuuagaugacgaagugguugaugccaugcuuccaagaaaagcuucuaagcuucagguaaccaggaaccguaccccaaaccgacacagguggucggguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggcaccguaacuucgggagaaggugcgccggcuagggugaaggauuuacuccguaagcucuggcuggucgaagauaccaggccgcugcgacuguuuauuaaaaacacagcacucugcaaacacgaaaguggacguauagggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaacgauggcggcgcugucuccacccgagacucagugaaauugaaaucgcugugaagaugcaguguauccgcggcuagacggaaagaccccgugaaccuuuacuguagcuuugcacuggacuuugagcgcaugcuugagguucuaacucugguccguaauccggaucgaggacaguguauggugggcaguuugacuggggcggucuccuccuaaagaguaacggaggaguacgaaggugcgcucagaccggucggaaaucggucgcagaguauaaaggcaaaagcgcgcuugacugcgagacagacacgucgagcagguacgaaaguaggucuuagugauccggugguucuguauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaagccggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccguggacguuugagauuugagaggggcugcuccuaguacgagaggaccggaguggacgaaccucugguguuccgguugucacgccaguggcauugccggguagcuauguucggaaaagauaaccgcugaaagcaucuaagcgggaaacuugccucaagaugagaucucacugggaacuugauuccccugaagggccgucgaagacuacgacguugauaggcuggguguguaagcguugugaggcguugagcuaaccaguacuaauugcccgugaggcuugacca <<<<<<<......<<<<<<<<<<<.....[[.(((<<<<<<<[[<<......<<<<<<.[[.(((.>>>.....<<<<<<<..<<<)))..]].>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...(((.....<<<<<<..<<<<<<.<<<...<<<.<......>.>>>((......<<<.....))>>>...>>>...>>>>>>..>>>>>>...........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.)))..............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<.....>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<.<<........>>.>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<..<<<<<<<<<.....<<<...<<<.<<<<...<<.<.....>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>....>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<<.......<<<<<.<<...<<<.........>>>...>>........<<<......>>>..>>>>>...>>>..>>>>>.>>...........)))......>>>>>>.>>>...>>>>>>><<<<<<<....>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<...((((...>>>>>><<..<<<....<<<<<<<<<<<..<<.....>>.>>>>>>>..>>>>....>>>...>><..<<<<.........>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<<<<<<<...<<<.....>>>....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<........>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))))>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<<<<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>...>>>>..>..>>>>>>>.. (((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]...].)))......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((....(((((...((((((.(((...(((.(......).)))[[(...).(((.....]])))...)))...))))))...)))))......)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((..).)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.((.((.......<)).)))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..(((((((((.....(((...(((.((((...(((((...))).))...)))).)))..)).).....)))))).)))....))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.((...((...........))...)).........((......))...)))))...)))..))))).))...........]]].)....))))))))))...)))))))(((((((....)))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((..((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..(((....((((((((((((.((.....))))))))))..))))..[.)))...))(..(((...........)))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))(((((((((.((...(((....])))....)).)))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((((..(........)..))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))..).)))))))).. PAO1 wild-type ribosome, R, reference map; 23S ribosomal RNA 8rwg B 1527 2.46 RF01959,RF00177,RF02542,RF01960 0003735 0005840 208964 gaacugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgagcggaugaagggagcuugcuccuggauucagcggcggacgggugaguaaugccuaggaaucugccugguagugggggauaacguccggaaacgggcgcuaauaccgcauacguccugagggagaaagugggggaucuucggaccucacgcuaucagaugagccuaggucggauuagcuaguuggugggguaaaggccuaccaaggcgacgauccguaacuggucugagaggaugaucagucacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauuggacaaugggcgaaagccugauccagccaugccgcgugugugaagaaggucuucggauuguaaagcacuuuaaguugggaggaagggcaguaaguuaauaccuugcuguuuugacguuaccaacagaauaagcaccggcuaacuucgugccagcagccgcgguaauacgaagggugcaagcguuaaucggaauuacugggcguaaagcgcgcguaggugguucagcaaguuggaugugaaauccccgggcucaaccugggaacugcauccaaaacuacugagcuagaguacgguagagggugguggaauuuccuguguagcggugaaaugcguagauauaggaaggaacaccaguggcgaaggcgaccaccuggacugauacugacacugaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuagccguugggauccuugagaucuuaguggcgcagcuaacgcgauaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccuggccuugacaugcugagaacuuuccagagauggauuggugccuucgggaacucagacacaggugcugcauggcugucgucagcucgugucgugagauguuggguuaagucccguaacgagcgcaacccuuguccuuaguuaccagcaccucgggugggcacucuaaggagacugccggugacaaaccggaggaagguggggaugacgucaagucaucauggcccuuacggccagggcuacacacgugcuacaauggucgguacaaaggguugccaagccgcgagguggagcuaaucccauaaaaccgaucguaguccggaucgcagucugcaacucgacugcgugaagucggaaucgcuaguaaucgugaaucagaaugucacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcuccagaaguagcuagucuaaccgcaagggggacgguuaccacggagugauucaugacuggggugaagucguaacaagguagccguaggggaaccugcggcuggauc ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<....<<<<<....>>>>>....>>.>>>>>......<<.......<<<<<<<..<<...<<<<<<<<<.<<.....<<<<<<....>>>>>>......>>.>.....<<<....>>>....<<<<<<..<<<..>>>>>>>>>>>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<<<<<<<<<<.......>>>>>>>>>>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<..<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>.>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<<..<<<......>>>.....>>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<.....>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<..<<<<....>>>>..>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((.....((((....)))).....)).)))))......(((......(((((((..((...(((((((((.((.....((((((....))))))......)).).....(((....)))....((((((..((....))))))))))))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(..((((((((((.......))))))))))...)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.((((((..((((((((((......((((((.....))))))....))))))))..)).))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((..(..((((....))))..)...((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....))))))))..)).)))))))).(...((((((......(((..((...(((....)))...))....)))......))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... PAO1 wild-type ribosome, R, reference map; 16S ribosomal RNA 8rwg C 120 2.46 RF00001 URS00005ACE34_208964 0003735 0005840 208964 ugcuugacgaucauagagcguuggaaccaccugaucccuucccgaacucagaagugaaacgacgcaucgccgaugguaguguggggucuccccaugugagaguaggucaucgucaagcuc .<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>><<<.......<<<<<<<<...>>>>>>>>.......>>>..>>>>>>>>>.. .(((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((...)))))))).......)))..))))))))).. PAO1 wild-type ribosome, R, reference map; 5S ribosomal RNA 8rxh L1 1677 2.93 RF02543 38722744 0003735 0005840 347515 cagaccugaguguggcaggacuacccgccgaacuuaagcauauuacncagcggaggaaaagaaaacanccgugauucucucagugagcggcgagcgaagagggaacgaacucguugccgaaucgggucuuacaaggccuugaguuguggcacaaauaucauugugugguuggugcaggaguggcgaaauucaagcgaaaagcaaacccguugcugaauacaacccuucaugugnguauugagccaaagaagguguuagcccauugagccauaaaccugagcgccucaugaauaagcgnguagcacuguuugggaaugcagugucaaguuggcagguauuugucugccaaaguuaaauacagaguaggaagaccgauagcgaacaaguagcgugagcgaanguuugaaaagcacuuuggaaagagagugaaauagaaccugaagucgugacaaagacaauggaaguaccuccauuucaacggccagaaccagcccuacugcauuauccugucggggaucaaaauccggcgggcaacgaagugcaagaaucuugggucuuggugaaaugagcggaguauuugagcugcgcacggcgcgccgcacgcacugguuucuucuccgugaugcuccauguuggcgauggaaauggggugcccccacccgucuuganacncggaccaaggagunanacagacgcgcaagggaggagauaugguugccaguacuucucucguacugaaagggagaugcaaaaugcaucuguggugugcacacgucaaauccguuugauuugcccaacaccgaccggcccuccguggguugcguuggagugugccngnuuggacccnanagguggugaacuaugccugaacaaggugaagcccggggaaacccagguggaggccuguagcgaugcugncgugcaaaucgcucguaugauuugggunucgnagcgaaagacucaucgaaccaccuaguagcugguucacaucgaaguuuccnucaggauagcuggugcuaguagaaguauugugcgguaaagcaaaugauuagaggucgaccuauucucaaacuuuaaangugcaaacaaaccgugccuuagccaacugcaaggccggaaagaaaagaauuagaggcaccaagugggccuucuucgguaagcngagcaggcgaugcggaaugaaccgcuuagggauauguggcgucaaaacuuaugggcucauucucgauacgugaaaaggguguugguggauacaguuggacccaaccgaauccaccggccccgaaaauggangncgcuuaagcccaauuagugauugcccauuauuccuuugguaagggcggaaacaaauggagaaaguguagcccuuccgauguagauguggccuggagguuaggacgaagcuuauggcgugagccuaagauggaccggccucuagugcanaunuugguuggcgunncaaagaucuaacggagauauacucaacaugcaacguuggauacuggagcggggaaggauuucgugccaacggcacucguacacganuuguucggaaacugagcacaacguuauaucgunuuguuaggaaagugaaggugugucggcggagcuguucgacugugaaaaggggcaacagagaaccugggauuauauuccaaaaagaaauugcauguggga .......................<<<<<......<......>.......>>>>.>.........<<....>>..<<<<<<......<<.....>>....>>>>>>...<<<...<<<<<..<<<<<<<......>>>>>.>>....>>>>>............<<<<...<<<<<<<<.<<<<<......<<<......<<<<.......>>>>.....<<........>>......>>>.<<.......((.....>>)).....>>>>>...>>>..>>>>>.>>>>............<<<<<<<........>>>>>>>......<<<<<........>>>>>..>>>....................................<<....>>................<<<<....>>>>..................................<<<..<<<<<<.<<<<<...<<.<<<<.<<<<<<<<....<<<<<..<<<<<<<<<........>>>>>>>>>.....>>.>>>.........>>>>..>>>>........<<<<<.....<<<<<..<<.<<<<..>>>>...>>...>>>.>>..>>>>>.....<<<<...>>>>>>....>>>>>>>>>>>..>>>.<<<<........>>>><<<<<<...<<<<<<<<.<<<<<..<<<..<<<.<............>>>>..>>>...<<....>>..<<<<<.....>>>>>...<<<<<...<<.<<<<<<....>>>>>>.>>....>>>>><<<<<<<<<.....>>>>>>.>>>...>>>>>.>>>>>>>>.<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<.<<<....>>>.>>>.....>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>...<<<<<....<.<<<....>>>.><<<<<<<<<.....<<...<<<<<<<...<<<....<<<....<<<....>>>....>>>..>.>>...>>>>>>>.....<<<.<<<<<.<<.....>>>>>>>>>>...........>>...>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>...<<<<......>>>>..<<<<<<<...<<<(((......<..<<<<........<...........<<<.<<<<<<<<<<..................>>>>>>>>>>>>>..........))).>....>>>>.>.........>>>...>>>>>>><<<<.<<<<<...........>>>>.........>>>>>>>>>....>>>>>....<<<<<<<<.........<<<..<<<....>>>.>>>.......>>>>>>>>........>>>>>>..............<<<<<<<....................>>>>>>>....................<<<<<....<<.....>>..>>>>>....<<..........<<.<<<<<......>>>>............<..<.<..<<.....<...>....>>..>.>..>...>.>>..........<<<<.........>>....>>.>>............ .......................(((((......(...[..).......)))).).........((....))...((((.......((.]...)).....))))....((.(...(.(..((((((((......))))).))....)).).............((((...((((((((.(((((....(.((.......((((.......)))).....((........)).......)))(((...).{[[.....))]].....)))))...)))..))))).)))).......)....((((.((........)).))))......(((((........)))))...))....................................((....)).............(..((.(....).))............)......................((..(((((..((((((..((.((((.((((.(((....((((...(.((((((..........)))))).)......).))).........)))...))))........(((((.....((((((..(.((.(..).))...)..).))).))..))))).....[[[[...))))))..).))))).)))))..))..(((..........)))(((..(....(((((.(.(((((..(((..(((..(....}.....).)))..)))...((....))..(((((.....)))))...((.((...((.(((((......))))).))....)).))(((((((((.....)))))).)))...))))).).)))))...(.(...((((((.....((((((((((..(((...(.(.(((....))).).)...).))....(((..((.((........)))).)))..).))))))))).(.((.......))...)..))))))......).)...((((((....(.(((....))).).((((((((.....((.(.((((((....(((....(((..(.(((....))).)..)))..)).)....)))))).....(((.(((((.((.....))))))))))..........)))...))))))).)...(((..((.((.....)).))..)))....(((......)))...(((((((...((([[[...(..(..((((........(...........(((.(((((.((((..................)))).))))))))..........]]].)....)))).))........)))...)))))))((((.((((((..........]]]]...).....)))))))))....))))).)(.((((.(((.(......((((..(((....))).))).)...).))).))))..).....)..)))..............(((((((....................)))))))....................(((((....((.....))..)))))....((......(...((.(.(((......))).............(........(..............)........)...).))....).....((((.........))....)).))............ CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME WITH A/P/E-site tRNA AND mRNA : PARENTAL STRAIN; LSUa_rRNA_chain_1 8rxh L2 1155 2.93 RF02543 38722744 0003735 0005840 347515 cccaacugcagancguacucaucaccgcaucagguccccaagcauagaaugcucngguacauagagaaangnacacucagggaagucggcaaanuagaugcguaaguucgcaagaagcauuggcucugagggcaaaaaauugccaacucagaacugnuuacggcggggaauccaacugunuaauuaaaacauagguuugugaugcauccaagugguguauaucgcaaacugauuucugccnagugcucugaaugucaacgugacgagauucaccgacgcgcggguaaacggcgggaguancuaugacucucuuaagguagcnaanugccucnucuuccaauuagagacgcgcaugaanggauuaaugngnuucccucugunccgaguuncuaucuagcgaancgacagucaagggaacggacuugnagggcuaagcggngaaagnagacccunuugaguuugncnccagucuggcucugugcgncgacaucugaggcucggaacguugcuucacuuaucgaaugaagagaccaauggguuuagcguagucuucgggcuaugcaccgucuagguuugggaguccccuguggguacccaaccgugcuguaaacugaaccaacgggauugcaguuccggagucuuguuucgagacaucugccagauggggaguuuggcugnggcggcauaucuguuacacgncaacgcaggnnuccuaaggcgagcucagugggaacagaaaucucacguagaacacaagcguaaaagcuugcuugauuaacgauuuccaguangaaucgagacugcgaaagcaaggccngcgauccuuugcgaagaauaggaaauaugaacaaaucauaccanangugucagaauaauuacnacagngauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuungaugucggnucuuccuaaccuagcgccgcagaagacgcuaaggguuggaunnuucacccacugncagggaacgugngcuggguuuagancgucgugagacagguugguuunacccuacuuagcuggaaauugcgagaaaaagauuauccgugcaaagcggacgucgggucguugggccuggcgagcgguggguaguacaugguacgcucaucacc ........................<<......>>......<<<<.....>>>>........<<<<....<<<<.<<<<.<<.........<.....<<<<<.....<..>......>>>>><<.<<<<<<<<<<<....>>>>>..>>>>>>.>>..........<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<....<<<<......>>>>....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>>.>>>>............<<<<<........>>>>>..<<<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<...<<<.<<<<<<.<<<.<<.>>.>>>..>>>>>>.>>>...<<<<<.....<<<<....<<.....<<<<<<<<....>>>>>>>>.>>.....<<<<.<<...<<.<..>.>>...>>.>>>>...................<<<<<......>>>>>..>>>>...>>>>>.......>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<......>>....>>>>>>>...<<...<<<<<.......>>>>>..>>.<<<....>>>.>>.........<<<<<..............<<<<.......>>>>.>>>>>..........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<<<<<<<.<......>.>>>>..>>>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>>>.......................<<<<.....>>>>.<<<<<<<<<....>>>>>>>>>.<.<<<<<<<.<<<<...>>>>>>>>>>>.>. ........................((......))......((((.....))))........(.((.....(((.((.(.((..(....(.......(((((....(.[..).....)))))((.(((((((..((....))..)..)))))).))..........(((((((((...((.........))...(((((((....((((.....))))......))))))).].(.(.(((..((((((.....((....(((........)))....))..))))..)))))(.(.(.........).).)........((..........(((((.......)))))..)..)....).)....)).))))))).)..))).).)))))..)).).........[..((.((......].)).))..(((((((..(((.((......((((.(((((...(((((.(((((((...((..((((((..(..((.))..)...))))))..))...(((((.....((((....(......((((.(((....))).))))..)..(..((((.((....(.(..).)....)).))))..)................((((((....))))))..))))...))))).......)))))))..)))))..(((......[)).)(((.(...........].).)))([((...(((((((.(.((((((.......))))))...).((][..[.))....))))))).(......(((...........)))....)(((....))).)).].].....((.((.(............((...........))))).))....)......)))..))))))............(.((((((...((.......))...))))))...).............((((.((((((..((.((((.(......).))))...)).(((.(.....).))).....)))))..)...))).)......((((((....))).))).....))..))).)))))))........................(((.....)))..(((((((((....))))))))).(.(((((((..(((...))).))))))).). CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME WITH A/P/E-site tRNA AND mRNA : PARENTAL STRAIN; LSUb_rRNA_chain_2 8rxh L3 183 2.93 38722744 347515 agugguaangcgaaacacuugccagguaacaaaucaauccucccacggugagcuuucuuuucaccauaauccaccuugggccuuuuuacuuucgcguuguucggagcgggggcucaagauugaaaaaugcagcucuuacugucauuugugaguucugcgcauuaaagcaaaaaccuggggugu .<<<....>>>.....<<<..<<<<<<.......<<...<<<<...<<<<<<.......>>>>>><...<<.<.<<<<<<<<<<<.......<<.......>>....>>>>>>>>>>>.>.>>....><..<.<......>.>..>.>.>>>...>>...............>>>>>>>>>.. .(((....))).....(.(..((((((.......((...((((...((((((.......))))))(...((.(.(((.((.((((.......((.......))....)))).)).))).).))....)(..(..........)..).).)))...))...............))))))).).. CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME WITH A/P/E-site tRNA AND mRNA : PARENTAL STRAIN; SR1_chain_3 8rxh L4 184 2.93 RF02543 38722744 0003735 0005840 347515 gugggauugugaagggaucucgcagguaucgugagggaaguaugggguaguacgagaggaacucccaugccgunccucuaguuucugggguuugucgaacggcaagugccccgaagccaucgcacggugguucucggcugaacgccucuaagccagaagccaaucccaagaccagaugcccacu <<<<<<<.........>>>>>>>.<<<<<<....<<<<.<<<<<<<<...............>>>>>>>><<<<<...<.<<....<<<<<<<<<......>>>>..>>>>>...>>.>..>>>>>.<<<<....<<<<...........>>>>....>>>>.>>>>.......>>>>>>.... (((.(((.........))).))).(((.(((...(((..(((((((......(....).....)))))))(((((...(.((....((((((((.(....).)))..)))))...)).)..))))).(.((....((...............))....)).)..))).....).)).))).... CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME WITH A/P/E-site tRNA AND mRNA : PARENTAL STRAIN; SR2_chain_4 8rxh L5 120 2.93 38722744 347515 uuacgucccucuccaaacgagagaacaugcaugggcuggcaugagcggcaugcuucuccgguggggcuccgucccgaggcgcugaaccuugaggccugaaaauucaugcucagggacacu ....<<<<<<<<<.......>>>>....<<<<<<<<.<<.....<<<.................<<.......>>....>>>....>>.....>>>........>>>>>...>>>>>... ....(((((((((.......)))).....((((.((.((.....(((..............(...(..(.)..)...).)))....)).....)).........))))....)))))... CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME WITH A/P/E-site tRNA AND mRNA : PARENTAL STRAIN; SR4_chain_5 8rxh L6 71 2.93 38722744 347515 aucgaaucgccaccuacaagacuggagcuugcucccucgaaggcgccaaguauauucaugaucacaagaca ......<.<<<............<<<<<..>>>>>......>>>........................>.. .......((((............(((((..)))))(..)..))).......................)... CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME WITH A/P/E-site tRNA AND mRNA : PARENTAL STRAIN; SR6_chain_6 8rxh L7 166 2.93 RF00002 38722744 0003735 0005840 347515 aacgugucgcgauggaugacuuggcuuccuauuucguugaagnacgcaguaaagugcgauaagugguaucaauuncagaaucauucaauuaccgaaucuuugaacgcaaacggcgcaugggagaagcucgugucauccccgugcaugccauauucucngugucgaa .........................................<<<<<<<<<....>>>>.....(<<<<......>>.............>>>>.)...>>>....<<.....>><<<<<<<.<..<<....>>..>.>>>>>>>...................... ...........................................((((.[[.....))).....(((((......]].............)))).)...)......((.....))(((((((....((.().))....)))))))...................... CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME WITH A/P/E-site tRNA AND mRNA : PARENTAL STRAIN; 5.8S_rRNA_chain_7 8rxh L8 120 2.93 RF00001 38722744 0003735 0005840 347515 gaguacgaccacacuugagugaaaacaccauaucccguccgauuugugaaguuaagcacucacaggcucaguuaguacugaggucagugaugacucgggaacccugagugccguacuccu <<<<<<<......<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<......<<<<<..<<....>>.>>>>>.....>>>>>>..>>>>>>>.. (((((((.(....((((((((.....((((((...(....)...))))..))....)))))).))((((((......(((((..((....)).))))).....))))))).))))))).. CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME WITH A/P/E-site tRNA AND mRNA : PARENTAL STRAIN; 5S_rRNA_chain_8 8rxh S1 1844 2.93 RF01960,RF02542,RF01959,RF00177 38722744 0003735 0005840 347515 gaucuggnugauucugcnaguagucaunngcuuguuunaaggacuuagccaugcaugccucagaaucacugcagcaggaaucugcgcauggcucnuuaaaucagacguaaucugccgcaaaaaucuugcggccgcaaaauuggauaacuuggcgaaacgccaagcuaauacaugaaccaaccggguguucuccacgugagacgcccagcgaaugaaugacaguaaaaccaaugccuugcaguaacacccagcaguguugacucaauucauuccgugcgaaagccggcuuguuccggcgucuuuugacgaacaacugcccuaucagcuggugauggccguguaguggacugccauggcguugacgggagcgggggauuaggguucgauuccggagagggagccugagaaauagcuaccacuucuacggagggcagcaggcgcgcnaauugcccaaugucaaaacaaaacgaugaggcngcgaaaagaaauagaguuguuugucauuucaaugggggauauuuaaacccauccaauaucgaguaacaauuggangacaagucuggugccagcacccgcgguaauuccagcuccaaaagcguauauuaaugcugungcuguunaaggguucguaguugaacugugggcugugcagggcccuugcagcccgugaaaaagaaacaagaaacacgggagugggucgcaugucaugcaugccagggggcguccgugauuuuuacugugacuaaagaagcgugacuaaagcagucauuugacuugaauuagaangcaugggauaacaaaggagcagccucuaggcuaccguuucggcuuuuguuguuuuuaaaggucuauuggagauuauggagcuguuucccacggugugacggccucuaggaaugaaggaggguaguucgggggagaacguacuggggcgucagaggugaaauucuuagaccgcaccaagacgaacuacagcgaaggcauucuucaaggauaccuuccucaaucaagaaccaaaguguggagaucgaagaugauuagaaaccauuguaguccacacugcaaacgaugacacccaugaauuggggauacuuaguaucuuuacgggaauauccucagcacgcacgcgaaagcuuugagguuacagucucaggggggaguacguucgcaanagugaaacuuaaagaaauugacggaauggcaccacaagacguggagcgugcgguuuaauuugacnnaacacngggaacuuuaccagauccggacaggaugagauugacagauugaguguucuuucucgauucccugaauggngnugcauggccgcuuauggucggugnagugauuuguuuggnugauuccgucaacggacgagauccaagcugcccaguagaauucagaauugcccauaggauagcgcauucggucgaauucuucucugcgggauuccuuuguaauugcacaaggugaaauuuugggcaacagcangucngugaugcuccucaauguucugggcgacacgcnnacuacaaugucagugagaacaagaaaaacgaucgaaccuacuugaucaaaagaguggggaaaccccggaaucacauagacccacuugggaccgaggauugcaauuanuggucgcgcaacgagnaaugucucguaggcgcagcucaucanacugugccgauuacgucccugccauuuguacacaccgncngucguuguuuccgaugauggugcaauacaggugaucggacaggcgcccgaaaguucaccgauauuunuucaauagagnaagcaaaagucguaacaagguagcuguaggggnnccugcagcugggacauuu ...<<<<<.{.[[[[>>>>><<<<.<<<<<<...<<<...<......<<<.<<<..<<....<<....<<<<.>>>>...>>.>>......<<..<.....<<<..<<..<<...<<.<<.....<<<<<..>>>>>...<<.....<<<<<<.....>>>>>>......>>..........<<<<<.<<<<.....>>>>>>>>>.<<<<<<<<<<.....(((((.((((<<...>>.........................>>>>>>>>...>>....<<<<<......>>>>>...>>.>>..>>>>..>>>.<<<....<<<....<<<<<.<<.......>>.>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>>>>.<<.<<<..........>>>.>>.<<<<....>>>>...>>>>>>.........<<<....<<<..........>>>..>>>..>....>>>....<<<.<<.....>>.>>>.....<<<<............>>>.....>.........<<<<<<<........((.....((..>>)).......))...>>>>>..>>>>>>>>>>.........<<<[[.....<<<<...<<<.......<...<<.<..<..>.>.>>...>...................<...............<<<<.......>>>>.............>.....<<<<<<<<.......<<...<.......>..<<<....>>>.....>>......>>>>>..>>>...........<<..<<<<<<.<<<...>>>.....)))).)))))..>>>>>>..>>.......<<<<<<<.<.<<...>>.>...>>>.>>>>............<<<<<..<<...<<<<<<<<..<<<<.<<<...<<<......>>>......>>>.>>>.>.>>.......<<....>>.>>>>>>...>>>>>.>>....>>>...>>>>...<<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>>.........<<<.<<..<<..<<<<<<<........<<..........>>.>>>>>>>..>>...<<..]]>>.....>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..]]]].}<<<<<.<<<<<<<..<<.<<<<<<..<<.<<<<<<<......<<........>>..........<<<<<.<....<<<<........<<.<<<........>>>.>>.......>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<<<.....<<<<<<<.<<<<.................>>>>....>>>>>>>.....>>>>....<<<<.<<......>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>>.>>.....<<<.<<<.......<.....<<..>>..<<<<<<<........>>>>>>>....>........>>>...>>>......<....<<<..<..........>..>>>.....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<<<<<..<<.<<<.<.<<<<..<<<<<.<...<.<....>.>...>.>>>>>..>>>>.>.>>>.>>..>>>>>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[..[[..))))((((.((((((...(((...((.....(((.(((..((....((....((((.))))...)){))......(((.......(((..((..((...((........(((((())))))...((.....((((((.....))))))......))..........(((((.(((((..).))))))))).(((((((.((.....[.[[[.[[[[.(...).................(......).)).)))))...))....((((((..)..)))))......))..))))..))).(((....(((....(((((.((.......)).))))))))......)))..(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(..((...(.((.}........))..))).).)....)))....((..((.....))..)).....((((............))).....).........((((([[........((.....((..]])).......))...)))))..))))))))))..{......((({{...(.((((...(((..(....(.........(..)........)...................(...............((((.......)))).............).....((.(((((.......((..((.......))................))......)))))...))........(..((..((((((.((.....)).....]]]].]]].]..))))))..)).......(((((.(((.((...)).)..)).).)))).)...)....(.(.(((..((...(((((.(((..(((.(((...((........))......))).)))..))).......((....))..)))))..)).)))..)...))))...))))....((((((....(...((((.........))))...).))))))......<...(((.((..((..(.((((((........(..........).)))))).)..))...((..}})).....))...}.))))))).(((......((((....))))....)))...]]..]((((..(.(((((..((..(((((..((.(((((((.......(........)...........(((((.(.....(((.....(..((.(.(........).).))....)..)))....((.((....(.((((((....(((.(((((....)))....((......))....)).))).....((((.((((.....(((.((((..((.................))....).))).))).....))))..(.((((.((......))))))....)..)))).....))).))).....)..)))).....).)))))...)).))))).)).(...(((((((.......(.....(.().)..((.((((........)))).))....)........))).).)))......(....((...(..........)...)).....)..)..))))).....(((((((.........)))))))......))...))))).).)).))..(.(..((.(.((((((((..(..(((.(.(.(((.(((((.(...(.((..)).)...).)))))).)).).).)))..)..))))))))..).))...)..)..(((((((((....)))))))))>........ CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME WITH A/P/E-site tRNA AND mRNA : PARENTAL STRAIN; SSU_rRNA_chain_S1 8rxh S2 76 2.93 RF00005 38722744 0030533 347515 gcgcggauagcucagucgguagagcaggggauugaanauccccguguccuugguucgauuccgaguccgcgcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>......................>>>>>>>.... ((((((...(((......[...))).(((((.......)))))........(...]....).....)))))).... CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME WITH A/P/E-site tRNA AND mRNA : PARENTAL STRAIN; A-site_tRNA_chain_S2 8rxh S3 75 2.93 RF00005 38722744 0030533 347515 gcgggguggagcagccuggagcucgucgggcucauaacccgaagaucgucgguucaaauccggcccccgcaacca <<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((.....[..)))).(((((.......))))).....(((((..]....)))))))))))..... CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME WITH A/P/E-site tRNA AND mRNA : PARENTAL STRAIN; P-site_tRNA_chain_S3 8rxh S4 74 2.93 RF00005 38722744 0030533 347515 gcgcggauagcucagucgguagagcaggggauuaaauccccguguccuugguucgauuccgaguccgcgcacca <<<<<<<..<<<<........>>>>.<<<<<<...>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((........)))).(((((.....))))).....(((((.......)))))))))))).... CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME WITH A/P/E-site tRNA AND mRNA : PARENTAL STRAIN; E-site_tRNA_chain_S4 8rxh S5 12 2.93 URS00021ED951_3039 38722744 347515 caccauguucaa ............ ............ CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME WITH A/P/E-site tRNA AND mRNA : PARENTAL STRAIN; mRNA_chain_S5 8rxx L1 1657 2.97 RF02543 38722744 0003735 0005840 347515 agaccugaguguggcaggacuacccgccgaacuuaagcauauuacucagcggaggaaaagaaaacanccgugauucucucagugagcggcgagcgaagagggaacgaacucguugccgaaucgggucuuacaaggccuugaguuguggcacaaauaucauugugugguuggugcaggaguggcgaaauucaagcgaaaagcaaacccguugcugaauacaacccuucaugugnguauugagccaaagaagguguuagcccauugagccauaaaccugagcgccucaugaacaagcgnguagcacuguuugggaaugcagugucaaguuggcagguauuugucugccaaaguuaaauacagaguaggaagaccgauagcgaacaaguagcgugagcgaanguuugaaaagcacuuuggaaagagagugaaauagaaccugaagucgugacaaagacaauggaaguaccuccauuucaacggccagaaccagcccuacugcauuauccugucggggaucaaaauccggcgggcaacgaagugcaagaaucuugggucuuggugaaaugagcggaguauuugagcugcgcacggcggccgcacgcacugguuucuucuccgugaugcuccauguuggcgauggaaauggggugcccccacccgucuugnnacncggaccaaggagunanacagacgcgcaagggaggagauaugguugccaguacuucucucguacugaaagggagaugcaaaaugcaucuguggugugcacacgucaaauccguuugauuugcccaacaccgaccggcccuccguggguugcguuggagugugccngnuuggacccnanagguggugaacuaugccugaacaaggugaagcccggggaaacccagguggaggccuguagcgaugcugncgugcaaaucgcucguaugauuugggunucgnagcgaaagacucaucgaaccaccuaguagcugguucacaucgaaguuuccnucaggauagcuggugcuaguagaaguaungugcgguaaagcaaaugauuagagggaccuauucucaaacuuuaaangugcaaacaaaccgugccuuagccaacugcaaggccggaaagaaaagaauuagaggcaccaagugggccuucuucgguaagcngagcaggcgaugcggaaugaaccgcuuagggauauguggcgucaaaacuuaugggcucauucucgauacgugaaaaggguguugguggauaaauccaccggccccgaaaauggangncgcuuaagcccaauuagugauugcccauuauuccuuugguaagggcggaaacaaauggagaaaguguagcccuuccgauguagauguggccuggagguuaggacgaagcuuauggcgugagccuaagauggaccggccucuagugcanaunuugguuggcgunncaaagaucuaacggagauauacucaacaugcaacguuggauacuggagcggggaaggauuucgugccaacggcacucguacacganuuguucggaaacugagcacaacguuauaucgunuuguuaggaaagugaaggugugucggcggagcuguucgacugugaaaaggggcaacagagaaccugggauuauauuccaaaaagaaauugcauguggga ......................<<<<<......<......>.......>>>>.>.........<<....>>..<<<<<<......<<.....>>....>>>>>>...<<<...<<<<<..<<<<<<<......>>>>>.>>....>>>>>............<<<<...<<<<<<<<.<<<<<......<<<......<<<<.......>>>>.....<<........>>......>>>.<<.......((.....>>)).....>>>>>...>>>..>>>>>.>>>>............<<<<<<<........>>>>>>>......<<<<<........>>>>>..>>>....................................<<....>>................<<<<....>>>>..................................<<<..<<<<<<.<<<<<...<<.<<<<.<<<<<<<<....<<<<<..<<<<<<<<<........>>>>>>>>>.....>>.>>>.........>>>>..>>>>........<<<<<.....<<<<<<.<<.<<<<.>>>>...>>.>.>>>.>>..>>>>>.....<<<<...>>>>>>....>>>>>>>>>>>..>>>.<<<<........>>>><<<<<<...<<<<<<<<.<<<<<..<<<..<<<.<............>>>>..>>>...<<....>>..<<<<<.....>>>>>...<<<<<...<<.<<<<<<....>>>>>>.>>....>>>>><<<<<<<<<.....>>>>>>.>>>...>>>>>.>>>>>>>>.<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<.<<<....>>>.>>>.....>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>...<<<<<....<.<<<....>>>.><<<<<<<<<.....<<...<<<<<<<...<<<....<<...<.<<<..>>>.>...>>..>>.>...>>>>>>>.....<<<.<<<<<.<<.....>>>>>>>>>>...........>>...>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>...<<<<......>>>>..<<<<<<<...<<<(((......<..<<<<........<...........<<<.<<<<<<<<<<..>>>>>>>>>>>>>..........))).>....>>>>.>.........>>>...>>>>>>><<<<.<<<<<...........>>>>.........>>>>>>>>>....>>>>>....<<<<<<<<.........<<<..<<<....>>>.>>>.......>>>>>>>>........>>>>>>..............<<<<<<<....................>>>>>>>....................<<<<<....<<.....>>..>>>>>....<<..........<<.<<<<<......>>>>............<.......<<...<......>...>>.....>.....>.>>..........<<<<.........>>....>>.>>............ ......................(((((......(...[..).......)))).).........((....))...((((.......((.]...)).....))))....((.(...(((..((((((((......))))).))....)))).............((((...((((((((.(((((....(.((.......((((.......))))....(((........)))......)))(((...).{[[.....))]].....)))))...)))..))))).)))).......)....(((((((........)))))))......(((((........)))))...))....................................((....)).............(..((.(....).))............)......................((..(((((..((((((..((.((((.((((.(((....((((...((((((((..........))))))))......).))).........)))...))))........(((((.....((((((..(.((.(.).))...)..).))).))..))))).....[[[[...))))))..).))))).)))))..))..((((........))))(((..(....(((((.(.(((((..(((..(((.((....}.....)))))..)))...((....))..(((((.....)))))...((.((...((.(((((......))))).))....)).))(((((((((.....)))))).)))...))))).).)))))..((.(...((((((.....((((((((((..(((...(((.(((....))).)))...).))....(((..((.((........)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).).((((((((.....((.(.((((((....(((....(((..(.(((..))).)..)))..)).)....)))))).....(((.(((((.((.....))))))))))..........)))...))))))).)...(((..((.((.....)).))..)))....(((......)))...(((((((...((([[[...(..(..((((........(...........(((.(((((.((((..)))).))))))))..........]]].)....)))).))........)))...)))))))((((.((((((..........]]]]...).....)))))))))....))))).)(.((((((((.(......((((..(((....))).))).)...).))))))))..).....)..)))..............(((((((....................)))))))....................(((((....((.....))..)))))....((......(...((.(.(((......))).............(.......((..............)).......)...).))....).....((((.........))....)).))............ CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME WITH A/P/E-site tRNA AND mRNA : LM32Cs3H1 sKO STRAIN; LSUa_rRNA_chain_1 8rxx L2 1149 2.97 RF02543 38722744 0003735 0005840 347515 cccaacugcagancguacucaucaccgcaucagguccccaagcauagaaugcucugguacauagagaaangnacacucagggaagucggcaaanuagaugcguaaguucgcaagaagcauuggcucugagggcaaaaaauugccaacucagaacugnuuacggcggggaauccaacugunuaauuaaaacauagguuugugaugcauccaagugguguauaucgcaaacugauuucugccnagugcucuggucaacgugacgagauucaccgacgcgcggguaaacggcgggaguancuaugacucucuuaagguagcnaanugccucnucuuccaauuagagacgcgcaugaanggauuaaugngnuucccucugunccgaguuncuaucuagcgaancgacagucaagggaacggacuugnagggcuaagcggngaaagaagacccunuugaguuugncnccagucuggcucugugcgncgacaucugaggcucggaacguugcuucacuuaucgaaugaagagaccaauggguuuagcguagucuucgggcuaugcaccgucuagguuugggaguccccuguggguacccaaccgugcuguaaacugaaccaacgggaucaguuccggagucuuguuucgagacacugccagauggggaguuuggcugnggcggcauaucuguuacacgacaacgcaggnnuccuaaggcgagcucagugggaacagaaaucucacguagaacacaagcguaaaagcuugcuugauuaacgauuuccaguangaaucgagacugcgaaagcaaggccngcgauccuuugcgaagaauaggaaauaugaacaaaucauaccanangugucagaauaauuacnacagngauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuungaugucggnucuuccuaaccuagcgccgcagaagacgcuaaggguuggaunnuucacccacugncagggaacgugngcuggguuuagancgucgugagacagguugguuunacccuacuuagcuggaaauugcgagaaaaagauuauccgugcaaagcggacgucgggucguugggccuggcgagcgguggguaguacaugguacncucaucacc ........................<<......>>......<<<<.....>>>>........<<<<....<<<<.<<<<.<<.........<.....<<<<<...............>>>>><<.<<<<<<<<<<<....>>>>>..>>>>>>.>>..........<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<..<<....<<<<......>>>>....>>..>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>>.>>>>............<<<<<........>>>>>..<<<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<...<<<.<<<<<<.<<<.<<.>>.>>>..>>>>>>.>>>...<<<<<.....<<<<....<<.....<<<<<<<<....>>>>>>>>.>>.....<<<<.<<...<<.<..>.>>...>>.>>>>...................<<<<<....>>>>>..>>>>...>>>>>......>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<......>>....>>>>>>>...<<...<<<<<.......>>>>>..>>.<<<....>>>.>>........<<<<<<..............<<<<.......>>>>.>>>>>>.........>>>>..>>>>>>.......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<<<<<<<.<......>.>>>>>..>>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>>>.......................<<<<.....>>>>.<<<<<<<<<....>>>>>>>>>.<.<<<<<<<.<<<<...>>>>>>>>>>>.>. ........................((......))......((((.....))))........(.((.....(((.((.(.((..(....(.......(((((....(.[..).....)))))((.(((((((((((....)))))..)))))).))..........(((((((((...((.........))...(((((((....((((.....))))......))))))).].(.(.(((..((((((..((....(((........)))....))..))))..)))))(.(.(.........).).)........((..........(((((.......)))))..)..)....).)....)).))))))).)..))).).)))))..)).).........[..((.((......].)).))..(((((((..(((.((......((((.(((((...(((((.(((((((...((..((((((..(..((.))..)...))))))..))...(((((.....((((....((.....((((.(((....))).)))).))..(..((((.((...((.(..).))...)).))))..)................((((((..))))))..))))...)))))......)))))))..)))))..(((......[)).)(((.(...........].).)))([((...(((((((.(.((((((.......))))))...).((][..[.))....))))))).(......(((...........)))....)(((....))).)).].].....((.((.(............((...........))))).))....)......)))..))))))............(.((((((...((.......))...))))))...).............((((.((((((..((.((((.(......).))))...)).(((.(.....).))).....)))))..)...))).)......((((((....))).))).....))..))).)))))))........................(((.....)))..(((((((((....))))))))).(.(((((((..(((...))).))))))).). CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME WITH A/P/E-site tRNA AND mRNA : LM32Cs3H1 sKO STRAIN; LSUb_rRNA_chain_2 8rxx L3 183 2.97 38722744 347515 agugguaangcgaaacacuugccagguaacaaaucaauccucccacggugagcuuucuuuucaccauaauccaccuugggccuuuuuacuuucgcguuguucggagcgggggcucaagauugaaaaaugcagcucuuacugucauuugugaguucugcgcauuaaagcaaaaaccuggggugu .<<......>>.....<<<..<<<<<<.......<<...<<<....<<<<<<.......>>>>>><...<<.<.<<<<<<<<<<<.......<<.......>>....>>>>>>>>>>>.>.>>....><..<..........>..>...>>>...>>...............>>>>>>>>>.. .(((....))).....(((..((((((.......((...((((...((((((.......))))))(...((.(.(((((((((((.......((.......))....))))))))))).).))....)(..(..........)..).).)))...))...............))))))))).. CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME WITH A/P/E-site tRNA AND mRNA : LM32Cs3H1 sKO STRAIN; SR1_chain_3 8rxx L4 184 2.97 RF02543 38722744 0003735 0005840 347515 gugggauugugaagggaucucgcagguaucgugagggaaguaugggguaguacgagaggaacucccaugccgunccucuaguuucugggguuugucgaacggcaagugccccgaagccaucgcacggugguucucggcugaacgccucuaagccagaagccaaucccaagaccagaugcccacu <<<<<<<.........>>>>>>>.<<<<<<....<<<<.<<<<<<<<...............>>>>>>>><<<<<...<.<<....<<<<<<<<<......>>>>..>>>>>...>>.>..>>>>>.<<<<....<<<<...........>>>>....>>>>.>>>>.......>>>>>>.... (((.(((.........))).))).(((.(((...(((..(((((((......(....).....)))))))(((((...(.((....((((((((.(....).)))..)))))...)).)..))))).(((.....(((.............))).....)))..))).....).)).))).... CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME WITH A/P/E-site tRNA AND mRNA : LM32Cs3H1 sKO STRAIN; SR2_chain_4 8rxx L5 122 2.97 38722744 347515 uuacgucccucuccaaacgagagaacaugcaugggcuggcaugagcggcaugcuucuccgguggggcucgacgucccgaggcgcugaaccuugaggccugaaaauucaugcucagggacacc ....<<<<<<<<<.......>>>>....<<<<<<<<.<<.....<<<.................<<..<<.>>..>>....>>>....>>.....>>>........>>>>>...>>>>>... ....(((((((((.......))))....((((((((.((.....(((..............(..((..((.))..))..).)))....)).....)))........)))))...)))))... CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME WITH A/P/E-site tRNA AND mRNA : LM32Cs3H1 sKO STRAIN; SR4_chain_5 8rxx L6 71 2.97 38722744 347515 aucgaaucgccaccuacaagacuggagcuugcucccucgaaggcgccaaguauauucaugaucacaagaca ......<.<<<............<<<<<..>>>>>......>>>........................>.. .......((((............(((((..)))))(..)..))).......................)... CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME WITH A/P/E-site tRNA AND mRNA : LM32Cs3H1 sKO STRAIN; SR6_chain_6 8rxx L7 166 2.97 RF00002 38722744 0003735 0005840 347515 aacgugucgcgauggaugacuuggcuuccuauuucguugaagnacgcaguaaagugcgauaagugguaucaauuncagaaucauucaauuaccgaaucuuugaacgcaaacggcgcaugggagaagcucgugucauccccgugcaugccauauucucngugucgaa .........................................<<<<<<<<<....>>>>.....(<<<<......>>.............>>>>.)...>>>....<<.....>><<<<<<<.<..<<....>>..>.>>>>>>>...................... ...........................................((((.[[.....))).....(((((......]].............)))).)...)......((.....))(((((((....((.().))....)))))))...................... CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME WITH A/P/E-site tRNA AND mRNA : LM32Cs3H1 sKO STRAIN; 5.8S_rRNA_chain_7 8rxx L8 119 2.97 RF00001 38722744 0003735 0005840 347515 gaguacgaccacacuugagugaaaacaccauaucccguccgauuugugaaguuaagcacucacaggcucaguuaguacugaggucagugaugacucgggaacccugagugccguacucc <<<<<<<......<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<......<<<<<..<<....>>.>>>>>.....>>>>>>..>>>>>>>. (((((((.(....((((((((.....((((((...(....)...))))..))....)))))).))((((((......(((((..((....)).))))).....))))))).))))))). CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME WITH A/P/E-site tRNA AND mRNA : LM32Cs3H1 sKO STRAIN; 5S_rRNA_chain_8 8rxx S1 1836 2.97 RF01960,RF02542,RF01959,RF00177 38722744 0003735 0005840 347515 gaucuggnugauucugcnaguagucauangcuuguuunaaggacuuagccaugcaugccucagaaucacugcagcaggaaucugcgcauggcucnuuaaaucagacguaaucugccgcaaaaaucuugcggccgcaaaauuggauaacuuggcgaaacgccaagcuaauacaugaaccaaccggguguucuccacgugagacgcccagcgaaugaaugacaguaaaaccaaugccuugcaguaacacccagcaguguugacucaauucauuccgugcgaaagccggcuuguuccggcgucuuuugacgaacaacugcccuaucagcuggugauggccguguaguggacugccauggcguugacgggagcgggggauuaggguucgauuccggagagggagccugagaaauagcuaccacuucuacggagggcagcaggcgcgcnaauugcccaaugucaaaacaaaacgaugaggcngcgaaaagaaauagaguuguuugucauuucaaugggggauauuuaaacccauccaauaucgaguaacaauuggangacaagucuggugccagcacccgcgguaauuccagcuccaaaagcguauauuaaugcugungcuguunaaggguucguaguugaacugugggcugugcagggcccuugcagcccgugaaaagaaacaagaaacacgggagugggucgcaugucaugcaugccagggggcguccgugauuuuuacugugacuaaagaagcgugacuaaagcagucauuugacuugaauuagaaagcaugggauaacaaaggagcagccucuaggcuaccguuucggcuuuuguuguuuuuaaaggucuauuggagauuauggagcuguuucccacggugugacggccucuaggaaugaaggaggguaguucgggggagaacguacuggggcgucagaggugaaauucuuagaccgcaccaagacgaacuacagcgaaggcauucuucaaggauaccuuccucaaucaagaaccaaaguguggagaucgaagaugauuagaaaccauuguaguccacacugcaaacgaugacacccaugaauuggggauacuuaguaucuuuacgggaauauccucagcacgcacgcgaaagcuuugagguuacagucucaggggggaguacguucgcaanagugaaacuuaaagaaauugacggaauggcaccacaagacguggagcgugcgguuuaauuugacnnaacacngggaacuuuaccagauccggacaggaugagauugacagauugaguguucuuucucgauucccugaauggngnugcauggccgcuuauggucggugnagugauuuguuugguugauuccgucaacggacgagauccaagcugcccaguagaauucagaauugcccauaggauagcgcauucggucgaauucuucucugcgggauuccuuuguaauugcacaaggugaaauuuugggcaacagcangucngugaugcuccucaauguucugggcgacacgcnnacuacaaugucagugagaacaagaaaacgaaccuacuugaucaaaagaguggggaaaccccggaaucacauagacccacuugggaccgaggauugcaaunuggucgcgcaacgagnaaugucucguaggcgcagcucaucanacugugccgauuacgucccugccauuuguacacaccgccngucguuguuuccgaugauggugcaauacaggugaucggacaggcgcccgaaaguucaccgauauuunuucaauagagnaagcaaaagucguaacaagguagcuguaggggnnccugcagcugggacauuu ...<<<<<.{.[[[[>>>>><<<<.<<<<<<...<<<..........<<<.<<<..<<....<<....<<<<.>>>>...>>.>>......<<........<<<..<<..<<...<<.<<.....<<<<<..>>>>>...<<.....<<<<<<.....>>>>>>......>>..........<<<<<.<<<<.....>>>>>>>>>.<<<<<<<<<<.....(((((.((((<<...>>.........................>>>>>>>>...>>....<<<<<......>>>>>...>>.>>..>>>>..>>>.<<<....<<<....<<<<<.<<.......>>.>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<.<<<..........>>>.>>.<<<<....>>>>...>>>>>>.........<<<....<<<..........>>>..>>>.......>>>....<<<.<<.....>>.>>>.....<<<<............>>>.....>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>>.........<<<[[.....<<<<...<<<.......<...<<....<..>...>>...>..................<...............<<<<.......>>>>.............>.....<<<<<<<<.......<<...<.......>..<<<....>>>.....>>......>>>>>..>>>...........<<..<<<<<<.<<.....>>.<...)))).)))))>.>>>>>>..>>.......<<<<<<<.<.<<...>>.>...>>>.>>>>............<<<<<..<<...<<<<<<<<<.<<<<.<<<...<<<......>>>......>>>.>>>.>>>>.......<<....>>.>>>>>>..>>.>>>.>>....>>>...>>>>...<<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>>.........<<<.<<..<<..<<<<<<<........<<..........>>.>>>>>>>..>>...<<..]]>>.....>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..]]]].}<<<<<.<<<<<<<..<<.<<<<<<..<<.<<<<<<<......<<........>>..........<<<<<.<....<<<<........<<.<<<........>>>.>>.......>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<<<.....<<<<<<<.<<<<.................>>>>....>>>>>>>.....>>>>....<<<<.<<......>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>>.>>.....<<<.<<<<......<........<<<<<<<........>>>>>>>....>.......>>>>...>>>...........<<<..<........>..>>>...........>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<<<<<..<<.<<<.<.<<<<..<<<<<.....<.<<..>>.>.....>>>>>..>>>>.>.>>>.>>..>>>>>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[..[[..))))((((.((((((...(((...((.....(((.(((..((....((....((((.))))...)){))......(((.......(((..((..((...((........(((((())))))...((.....((((((.....))))))......))..........(((((.(((((..).))))))))).(((((((.((.....[[[[[.[[[[.......................(......).)).)))))...))....((((((..)..)))))......))..))))..))).(((....(((....(((((.((.......)).))))))))......)))..(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...(.((.}........))..))))).)....)))....(((.((.....)).)))...(.((((............))).....)......)..((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.((((...(((..(....(.........(..)........)..................(...............((((.......)))).............).....((.(((((.......((..((.......))................))......)))))...))........(..((..((((((.((.....)).....]]]].]]]]]..))))))..)).......(((((((((.((...)).)..)))).)))).)...)....(.(((((..((...(((((.(((..(((.(((...(..........)......))).)))..))).......((....))..)))))..)).))).))...))))...))))....((((((....(...((((.........))))...).))))))......<...(((.((..((..((((((((........(.(......).).))))))))..))...((..}})).....))...}.))))))).(((......((((....))))....)))...]]..]((((..(.(((((..((..(((((..((.(((((((.......(........)...........(((((.(.....(((.....(..((.(.(........).).))....)..)))....((..(....(.((((((....(((.(((((....)))....((......))....)).))).....((((.((((.....(((.((((..((.................))....).))).))).....))))..(.((((.((......))))))....)..)))).....))).))).....)..).)).....).)))))...)).))))).)).(...(((((((.......(........((.((((........)))).))....)........))).).)))......(....((...(........)...)).....)..)..))))).....(((((((.........)))))))......))...))))).).)).))..(.(..((.(.((((((((..(..(((.(.(.(((.(((((.(...(.((..)).)...).)))))).)).).).)))..)..))))))))..).))...)..)..(((((((((....)))))))))>........ CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME WITH A/P/E-site tRNA AND mRNA : LM32Cs3H1 sKO STRAIN; SSU_rRNA_chain_S1 8rxx S2 12 2.97 38722744 347515 gauugaanaucc <<<.....>>>. ((.......)). CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME WITH A/P/E-site tRNA AND mRNA : LM32Cs3H1 sKO STRAIN; A-site_tRNA_chain_S2 8rxx S3 71 2.97 RF00005 38722744 0030533 347515 cgcgggguggagcagagcucgucgggcucauaacccgaagaucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<...>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((...)))).(((((.......))))).....(((((.......)))))))))))..... CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME WITH A/P/E-site tRNA AND mRNA : LM32Cs3H1 sKO STRAIN; P-site_tRNA_chain_S3 8rxx S4 66 2.97 38722744 347515 gcgcggauagcucaguagagcaggggauaauccccgugcuugguucgauuccgaguccgcgcacca <<<<<<<..<<<<....>>>>.<<<<<...>>>>>...<<<<<.......>>>>>>>>>>>>.... (((((((..((((....)))).(((((...)))))...(((((.......)))))))))))).... CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME WITH A/P/E-site tRNA AND mRNA : LM32Cs3H1 sKO STRAIN; E-site_tRNA_chain_S4 8rxx S5 11 2.97 38722744 347515 caccauguuca ........... ........... CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME WITH A/P/E-site tRNA AND mRNA : LM32Cs3H1 sKO STRAIN; mRNA_chain_S5 8s1p A 2733 1.96 RF02541 38811035 0003735 0005840 224308 uuaaguuagaaagggcgcacgguggaugccuuggcacuaggagccgaugaaggacgggacgaacaccgauaugcuucggggagcuguaagcaagcuuugauccggagauuuccgaauggggaaacccaccacucguaauggagugguauccauaucugaauucauaggauaugagaaggcagacccggggaacugaaacaucuaaguacccggaggaagagaaagcaaaugcgauucccugaguagcggcgagcgaaacgggaucagcccaaaccaagaggcuugccucuugggguuguaggacacucuguaggaguuacaaaggaacgagguagaugaagaggucuggaaaggcccgccauaggagguaacagcccuguagucaaaacuucguucucuccugaguggauccugaguacggcggaacacgugaaauuccgucggaauccgggaggaccaucucccaaggcuaaauacucccuagugaccgauagugaaccaguaccgugagggaaaggugaaaagcaccccggaaggggagugaaagagauccugaaaccgugugccuacaaguagucagagcccguuaacgggugauggcgugccuuuuguagaangaaccggcgaguuacgaucucgugcaagguuaagcagaagaugcggagccgcagcgaaagcgagucugaauagggcgcaaguacguggucguagacccgaaaccaggugaucuacccauguccagggugaaguuaauggaggcccgaacccacgcacgungaaaagugcggggaugagguguggguaggggugaaaugccaaucgaaccuggagauagcugguucucuccgaaauagcuuuagggcuagccucaagguaagagucuuggagguagagcacugauuggacuagggguuaccgaauucagucaaacuccgaaugccaaugacuuauccuugggagucagacugcgagugauaagauccguagucgaaagggaaacagcccagaccgccagcuaaggucccaaaguauacguuaaguggaaaaggauguggaguugcuuagacaaucgagugacucugcgccgaaaauguaccggggcuaaacguaucaccgaagcugcggacuguucgaacagugguaggagagcguucuaagggcugugaagccagaccggaaggacugguggagcgcuuagaagugagaaugccgguaugaguagcgaaagaggggugagaauccccuccaccgaaugccuaagguuuccugaggaaggcucguccgcucaggguuagucgggaccuaagccgaggccgaaaggcguaggcgauggacaacagguugauauuccuguaccaccuccucaccauuugagcaauggggggacgcaggaggauaggguaagcgcgguauuggauauccgcguccaagcaguuaggcugggaaauaggcaaauccguuucccaaaggcugagcugugauggcgagcgcgaaguuccugauuccacacugccaagaaaagccucuagcgaggugagaggugcccguaccgcaaaccgacacagguaggcgaggagagaauccuaaggugaucgagagaacucucguuaaggaacucggcaaaaugaccccguaacuucgggagaaggggugcucuguagggugcaagcccgagagagccgcagugaauaggcccaggcgacuguuuagcaaaaacacaggucucugcgaagccguaaggcgaaguauaggggcugacgccugcccggugcuggaagguuaagaggagcgcuuagcguaagcgaaggugcgaauugaagccccaguaaacggcggccgcgguccuaagguagcgaaanuccuugucggguaaguuccgacccgcacgaaaggcgcaacgaucugggcacugucucaacgagagacucggugaaauuauaguaccugugaagaugcagguuacccgcgacaggacggaaagaccccguggagcuuuacugcagccugauauugaauguugguaauugaccuucuaacccgccgcccuuaucgggcggggagacagugucaggugggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguucccucagaaugguuggaaaucauucgcagaguguaaaggcacaagggagcuugacugcgagaccuacaagucgagcagggacgaaagucgggcuuagugauccggugguuccgcauggaagggccaucgcucaacggauaaaagcuaccccgngganaacaggcuuaucucccccaagaguccacaucgacggggagguuuggcaccucgnugucggcucaucgcauccuggggcuguagucggucccaaggguugggcunuucgcccauuaaagcgguacncgagcuggguucagaacgucgugagacaguucggucccuauccgucgcgggcgcaggaaauuugagaggagcuguccuuaguacgagaggaccgggauggacgcaccgcugguguaccaguuguucugccaagggcaucgcuggguagcuaugugcggacgggauaagugcugaaagcaucuaagcaugaagccccccucaagaugagauuucccauuccgcaaggaaguaagaucccugaaagaugaucagguugauaggucugagguggaaguguggcgacacauggagcugacagauacuaaucgaucgaggacuuaac <<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<..[..((.>>>.....<<<<<<<..<<<))..]..>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<<<<<<<<.........>>>>>>>.>>.>>....<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<......<<.....>>.....>>>>...(((....<<<<<<<<....>>>>>>>>......<<<<<<<<<....<<<<.......<<<<<<<<<<.<<<.....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>.>>>>>..>>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<....>>>>..................>>>>>>>>>>>.......<<<<..<<<<......>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<.<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....>>>>>.>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<..>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<...<<<<<<<<<.....<<<...<<<<<<<<...<<<..>.>>...>>>>>>>>..>>.>.....>>>>.>>>>>..>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<<.....<....>.>>>>>>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<..>>>>>>....>>>>>>..<<<<<<<.<<......<<<<<.<<....>>.>>>>>...>>.>>>>>>>........>>>>>><......<<....<<<<<<.......>>>>>><<<<....<<<<<.<<<..<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<.<<<<<<......<<...<<<<....<<<<..<<<..<<<.<<<<<<<<...(((....>>>>>><<..<<<<<..<<<<<<<<<<<.<<.....>>>>>>>>>...>>>>..>>>>>...>><..<..>...>>>>>>...>>>...>>>>.........>>>>..>>..>>>>>>>>>>>>>>>.>>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<...<<<<....>>>>...>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>..<<<<.<<<..<<<<<<<..<<<<..<<...<<<<<..<<....>>...>>>>>...>>..>>>>>>>>>..>>>>><<<<..>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>...>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.(...<<<<<.......)>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<<.<<<.<<<<<<.>>>>>>.>>>....<<.<<<<<<.....>>>>>>>>.....>>>>>>>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.)))>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>. ((((((......((((((((((.....(((..(((((((((((((......((((((.....[[[)))...].((((((...(((]].....)))......))))))...)))....(((....)))(((((((......))))))).(((((((((.........))))))).)).))....((((((.....(...[..)......))))).).........((....))...((((......((.]...)).....))))...((((...(((((((((..)))))))))....{.(((((((((....((((.......((((((((((.(((...(.((((......)))))[[(...).(((.....]])))...)))...)))))))))))))).)))))..)))))....((((((((..[......))))))))....}.(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((..((((..[...))))..)))).<.(.(........).).((((((....(((((((.(((((..(((...(((.....)))...)))...((....))..((((.....))))....))))).)))))))..((.(...((((((.....((((((((((.((((...((()))...)<)))...(((.(((((.......A))))))))..).))))))))).(.(((....[)))...).]))))))......).))..((((((....(((((....)))))(((((((((...(((((((((.....(((...((((((((...(((()).))...))))))))..)).).....)))).)))))..))))))).))..(((((((.(........).)))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......()...)))))))))).))...........]]].)...))))))))))...)))))))((((((()))))))....))))))(.(((((((.((......(((((.((....))])))))...)).)))))))..).....))))))(......((....((((((.......))))))((((....(((...((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((.((((((......((...((((....((((..(((..(((.(((((((((...{{..).))))))((..(((((..(((((((((((.((.....)))))))))...))))..)))))...))(..(())...))))))...)))...))))(..).....))))..))..))))))))))))))).))).....((......))..))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.[..).....)))))(((((...((((....))))...)))))(...).......(((((((((.>.((.........))...(((((((.....(((....))).......))))))).]((((.(((..(((((((..(((...((...(((((..((....))...)))))...))...))))))))..)))))((((()))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).[..(((((.....>].)))))..((((((((.(((.((......((((.((((((..(((((.(((((((((.(((.((((.(.).)))).)))....((.((((((.....)))))))).....)))))))))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..a.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))..)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.((((....))))....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))...))))))). YlmH bound to PtRNA-50S; 23S rRNA 8s1p B 112 1.96 RF00001 38811035 0003735 0005840 224308 ugguggcgauagcgaagaggucacacccguucccauaccgaacacggaaguuaagcucuucagcgccgaugguagucggggguuucccccugugagaguaggacgccgccaa <<<<<<<....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<.......<<.<<<<<...>>>>>.>>.......>>..>>>>>>>. (((((((....((((((((.....((((((...(.....)...))))..))....)))))).)).((.......((.(((((...))))).)).......))..))))))). YlmH bound to PtRNA-50S; 5S rRNA 8s1p a 69 1.96 RF00005 URS00002F180C_224308 38811035 0030533 0006412 224308 ggggccuuagcucaggggagagcgccugcucgcaggaggucagcgguucgaucccgcuaggcuccacca <<<<<<<..<<<<......>>>>.<<<<<..>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[..)))).(((((..))))).....(((((..]....)))))))))))).... YlmH bound to PtRNA-50S; P-tRNA 8s1u B 112 3.4 RF00001 38811035 0003735 0005840 224308 ugguggcgauagcgaagaggucacacccguucccauaccgaacacggaaguuaagcucuucagcgccgaugguagucggggguuucccccugugagaguaggacgccgccaa <<<<<<<....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<.......<<.<<<<<...>>>>>.>>.......>>..>>>>>>>. (((((((....((((((((.....((((((...(.....)...))))..))....)))))).)).((.......((.(((((...))))).)).......))..))))))). YlmH bound to stalled 50S subunits with RqcH and PtRNA; 5S rRNA 8s1u a 69 3.4 RF00005 URS00002F180C_224308 38811035 0030533 0006412 224308 ggggccuuagcucaggggagagcgccugcucgcaggaggucagcgguucgaucccgcuaggcuccacca <<<<<<<..<<<<......>>>>.<<.<....>.>>.....<<<<.........>>>>>>>>>>>.... ((.((((..((((...[..)))).((.(....).)).....((((...].....)))))))).)).... YlmH bound to stalled 50S subunits with RqcH and PtRNA; P-tRNA 8s1u A 2789 3.4 RF02541 38811035 0003735 0005840 224308 uuaaguuagaaagggcgcacgguggaugccuuggcacuaggagccgaugaaggacgggacgaacaccgauaugcuucggggagcuguaagcaagcuuugauccggagauuuccgaauggggaaacccaccacucguaauggagugguauccauaucugaauucauaggauaugagaaggcagacccggggaacugaaacaucuaaguacccggaggaagagaaagcaaaugcgauucccugaguagcggcgagcgaaacgggaucagcccaaaccaagaggcuugccucuugggguuguaggacacucuguaggaguuacaaaggaacgagguagaugaagaggucuggaaaggcccgccauaggagguaacagcccuguagucaaaacuucguucucuccugaguggauccugaguacggcggaacacgugaaauuccgucggaauccgggaggaccaucucccaaggcuaaauacucccuagugaccgauagugaaccaguaccgugagggaaaggugaaaagcaccccggaaggggagugaaagagauccugaaaccgugugccuacaaguagucagagcccguuaacgggugauggcgugccuuuuguagaangaaccggcgaguuacgaucucgugcaagguuaagcagaagaugcggagccgcagcgaaagcgagucugaauagggcgcaaguacguggucguagacccgaaaccaggugaucuacccauguccagggugaaguuaauggaggcccgaacccacgcacgungaaaagugcggggaugagguguggguaggggugaaaugccaaucgaaccuggagauagcugguucucuccgaaauagcuuuagggcuagccucaagguaagagucuuggagguagagcacugauuggacuagggguuaccgaauucagucaaacuccgaaugccaaugacuuauccuugggagucagacugcgagugauaagauccguagucgaaagggaaacagcccagaccgccagcuaaggucccaaaguauacguuaaguggaaaaggauguggaguugcuuagacaaccaggauguuggcuuagaagcagccaccauuuaaagagugcguaauagcucacuggucgagugacucugcgccgaaaauguaccggggcuaaacguaucaccgaagcugcggacuguucgaacagugguaggagagcguucuaagggcugugaagccagaccggaaggacugguggagcgcuuagaagugagaaugccgguaugaguagcgaaagaggggugagaauccccuccaccgaaugccuaagguuuccugaggaaggcucguccgcucaggguuagucgggaccuaagccgaggccgaaaggcguaggcgauggacaacagguugauauuccuguaccaccuccucaccauuugagcaauggggggacgcaggaggauaggguaagcgcgguauuggauauccgcguccaagcaguuaggcugggaaauaggcaaauccguuucccaaaggcugagcugugauggcgagcgcgaaguuccugauuccacacugccaagaaaagccucuagcgaggugagaggugcccguaccgcaaaccgacacagguaggcgaggagagaauccuaaggugaucgagagaacucucguuaaggaacucggcaaaaugaccccguaacuucgggagaaggggugcucuguagggugcaagcccgagagagccgcagugaauaggcccaggcgacuguuuagcaaaaacacaggucucugcgaagccguaaggcgaaguauaggggcugacgccugcccggugcuggaagguuaagaggagcgcuuagcguaagcgaaggugcgaauugaagccccaguaaacggcggccgcgguccuaagguagcgaaanuccuugucggguaaguuccgacccgcacgaaaggcgcaacgaucugggcacugucucaacgagagacucggugaaauuauaguaccugugaagaugcagguuacccgcgacaggacggaaagaccccguggagcuuuacugcagccugauauugaauguugguaauugaccuucuaacccgccgcccuuaucgggcggggagacagugucaggugggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguucccucagaaugguuggaaaucauucgcagaguguaaaggcacaagggagcuugacugcgagaccuacaagucgagcagggacgaaagucgggcuuagugauccggugguuccgcauggaagggccaucgcucaacggauaaaagcuaccccgngganaacaggcuuaucucccccaagaguccacaucgacggggagguuuggcaccucgnugucggcucaucgcauccuggggcuguagucggucccaaggguugggcunuucgcccauuaaagcgguacncgagcuggguucagaacgucgugagacaguucggucccuauccgucgcgggcgcaggaaauuugagaggagcuguccuuaguacgagaggaccgggauggacgcaccgcugguguaccaguuguucugccaagggcaucgcuggguagcuaugugcggacgggauaagugcugaaagcaucuaagcaugaagccccccucaagaugagauuucccauuccgcaaggaaguaagaucccugaaagaugaucagguugauaggucugagguggaaguguggcgacacauggagcugacagauacuaaucgaucgaggacuuaac <<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<..[..((.>>>.....<<<<<<<..<<<))..]..>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<<<<<<<<.........>>>>>>>.>>.>>....<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<......<<.....>>.....>>>>...(((....<<<<<<<<....>>>>>>>>......<<<<<<<<<....<<<<.......<<<<<<<<<<.<<<.....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>.>>>>>..>>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<....>>>>..................>>>>>>>>>>>.......<<<<..<<<<......>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<.<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....>>>>>.>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<..>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<...<<<<<<<<<.....<<<...<<<<<<<<...<<<..>.>>...>>>>>>>>..>>.>.....>>>>.>>>>>..>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<..>>>>>>....>>>>>>..<<<<<<<.<<......<<<<<.<<....>>.>>>>>...>>.>>>>>>>........>>>>>>.......<<....<<<<<<.......>>>>>><<<<....<<<<<.<<<..<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<.<<<<<<......<<...<<<<....<<<<..<<<..<<<.<<<<<<<<...(((....>>>>>><<..<<<<<..<<<<<<<<<<<.<<.....>>>>>>>>>...>>>>..>>>>>...>><..<..>...>>>>>>...>>>...>>>>.........>>>>..>>..>>>>>>>>>>>>>>>.>>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<...<<<<....>>>>...>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>..<<<<.<<<..<<<<<<<..<<<<..<<...<<<<<..<<....>>...>>>>>...>>..>>>>>>>>>..>>>>><<<<..>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>...>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.......(...<<<<<.......)>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<<.<<<.<<<<<<.>>>>>>.>>>....<<.<<<<<<.....>>>>>>>>.....>>>>>>>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.)))>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>. ((((((......((((((((((.....(((..(((((((((((((......((((((.....[[[)))...].((((((...(((]].....)))......))))))...)))....(((....)))(((((((......))))))).(((((((((.........))))))).)).))....((((((.....(...[..)......))))).).........((....))...((((......((.]...)).....))))...((((...(((((((((..)))))))))....{.(((((((((....((((.......((((((((((.(((...(.((((......)))))[[(...).(((.....]])))...)))...)))))))))))))).)))))..)))))....((((((((..[......))))))))....}.(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((..((((..[...))))..)))).<.(.(........).).((((((..(.(((((((.(((((..(((...(((.....)))...)))...((....))..((((.....))))....))))).)))))))..((.(...((((((.....((((((((((.((((...((()))...)<)))...(((.(((((.......A))))))))..).))))))))).(.(((....[)))...).]))))))......).))).((((((....(((((....)))))(((((((((...(((((((((.....(((...((((((((...(((()).))...))))))))..)).).....)))).)))))..))))))).))..(((((((.(........).)))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((.(((((.......(((((.(((...((.........))...))).....(...((......)).).)))))...))))).)))).))...........]]].)...))))))))))...)))))))((((((()))))))....))))))(.(((((((.((......(((((.((....))])))))...)).)))))))..).....))))))(......((....((((((.......))))))((((....(((...((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((.((((((......((...((((....((((..(((..(((.(((((((((...{{..).))))))((..(((((..(((((((((((.((.....)))))))))...))))..)))))...))(..(())...))))))...)))...))))(..).....))))..))..))))))))))))))).))).....((......))..))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.[..).....)))))(((((...((((....))))...)))))(...).......(((((((((.>.((.........))...(((((((.....(((....))).......))))))).]((((.(((..(((((((..(((...((...(((((..((....))...)))))...))...))))))))..)))))((((()))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).[..(((((.....>].)))))..((((((((.(((.((......((((.((((((..(((((.(((((((((.(((.((((.(.).)))).)))....((.((((((.....)))))))).....)))))))))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..a.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))..)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.((((....))))....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))...))))))). YlmH bound to stalled 50S subunits with RqcH and PtRNA; 23S rRNA 8s6w A 36 5.3 32630 uggaagaaaucgaagaagaugaagaacgcgaagaac .................................... .................................... Small circular RNA dimer - Class 3; RNA (36-MER) 8s6w B 36 5.3 32630 uggaagaaaucgaagaagaugaagaacgcgaagaac .................................... .................................... Small circular RNA dimer - Class 3; RNA (36-MER) 8s6w C 36 5.3 32630 aucuucuucgauuucuuccaguucuucgcguucuuc .................................... .................................... Small circular RNA dimer - Class 3; RNA (36-MER) 8s6w D 36 5.3 32630 aucuucuucgauuucuuccaguucuucgcguucuuc .................................... .................................... Small circular RNA dimer - Class 3; RNA (36-MER) 8s8d 2 1798 3.45 RF01960,RF02542,RF01959,RF00177 39193907 0003735 0005840 284590 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Structure of a yeast 48S-AUC preinitiation complex in closed conformation (model py48S-AUC-2); 18S ribosomal RNA 8s8d 3 26 3.45 39193907 28985 cucuaacuauaaaaaucucucuucuc .......................... .......................... Structure of a yeast 48S-AUC preinitiation complex in closed conformation (model py48S-AUC-2); mRNA (5'-R(P*AP*AP*U)-3') 8s8d 1 75 3.45 RF00005 39193907 0030533 559292 agcgccgunncgcagnggaagcgcncagggcucaunacccugaunnnnucggaucgnaaccgngcggcgcuacca <<<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((....[..)))).(((((.......))))).....(((((..]....)))))))))))).... Structure of a yeast 48S-AUC preinitiation complex in closed conformation (model py48S-AUC-2); Met-tRNAi 8s8e 2 1798 3.85 RF01960,RF02542,RF01959,RF00177 39193907 0003735 0005840 284590 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Structure of a yeast 48S-AUC preinitiation complex in closed conformation (model py48S-AUC-3.1); 18S ribosomal RNA 8s8e 3 26 3.85 39193907 28985 cucuaacuauaaaaaucucucuucuc .......................... .......................... Structure of a yeast 48S-AUC preinitiation complex in closed conformation (model py48S-AUC-3.1); mRNA (5'-R(P*AP*AP*U)-3') 8s8e 1 75 3.85 RF00005 39193907 0030533 559292 agcgccgunncgcagnggaagcgcncagggcucaunacccugaunnnnucggaucgnaaccgngcggcgcuacca <<<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((....[..)))).(((((.......))))).....(((((..]....)))))))))))).... Structure of a yeast 48S-AUC preinitiation complex in closed conformation (model py48S-AUC-3.1); Met-tRNAi 8s8f 2 1789 3.95 RF01960,RF02542,RF01959,RF00177 39193907 0003735 0005840 284590 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Structure of a yeast 48S-AUC preinitiation complex in closed conformation (model py48S-AUC-3.2); 18S ribosomal RNA 8s8f 3 26 3.95 39193907 28985 cucuaacuauaaaaaucucucuucuc .......................... .......................... Structure of a yeast 48S-AUC preinitiation complex in closed conformation (model py48S-AUC-3.2); mRNA (5'-R(P*AP*AP*U)-3') 8s8f 1 75 3.95 RF00005 39193907 0030533 559292 agcgccgunncgcagnggaagcgcncagggcucaunacccugaunnnnucggaucgnaaccgngcggcgcuacca <<<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((....[..)))).(((((.......))))).....(((((..]....)))))))))))).... Structure of a yeast 48S-AUC preinitiation complex in closed conformation (model py48S-AUC-3.2); Met-tRNAi 8s8g 2 1798 4.0 RF01960,RF02542,RF01959,RF00177 39193907 0003735 0005840 284590 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Structure of a yeast 48S-AUC preinitiation complex in closed conformation (model py48S-AUC-2.1); 18S ribosomal RNA 8s8g 3 26 4.0 39193907 28985 cucuaacuauaaaaaucucucuucuc .......................... .......................... Structure of a yeast 48S-AUC preinitiation complex in closed conformation (model py48S-AUC-2.1); mRNA (5'-R(P*AP*AP*U)-3') 8s8g 1 75 4.0 RF00005 39193907 0030533 559292 agcgccgunncgcagnggaagcgcncagggcucaunacccugaunnnnucggaucgnaaccgngcggcgcuacca <<<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((....[..)))).(((((.......))))).....(((((..]....)))))))))))).... Structure of a yeast 48S-AUC preinitiation complex in closed conformation (model py48S-AUC-2.1); Met-tRNAi 8s8h 2 1798 4.0 RF01960,RF02542,RF01959,RF00177 39193907 0003735 0005840 284590 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Structure of a yeast 48S-AUC preinitiation complex in closed conformation (model py48S-AUC-2.2); 18S ribosomal RNA 8s8h 3 26 4.0 39193907 28985 cucuaacuauaaaaaucucucuucuc .......................... .......................... Structure of a yeast 48S-AUC preinitiation complex in closed conformation (model py48S-AUC-2.2); mRNA (5'-R(P*AP*AP*U)-3') 8s8h 1 75 4.0 RF00005 39193907 0030533 559292 agcgccgunncgcagnggaagcgcncagggcucaunacccugaunnnnucggaucgnaaccgngcggcgcuacca <<<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... ((((((([.((((]...[..)))).(((((.......))))).....(((((..]....)))))))))))).... Structure of a yeast 48S-AUC preinitiation complex in closed conformation (model py48S-AUC-2.2); Met-tRNAi 8s8i 2 1789 4.3 RF01960,RF02542,RF01959,RF00177 39193907 0003735 0005840 284590 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Structure of a yeast 48S-AUC preinitiation complex in closed conformation (model py48S-AUC-eIF1); 18S ribosomal RNA 8s8i 3 26 4.3 39193907 28985 cucuaacuauaaaaaucucucuucuc .......................... .......................... Structure of a yeast 48S-AUC preinitiation complex in closed conformation (model py48S-AUC-eIF1); mRNA (5'-R(P*AP*AP*U)-3') 8s8i 1 75 4.3 RF00005 39193907 0030533 559292 agcgccgunncgcagnggaagcgcncagggcucaunacccugaunnnnucggaucgnaaccgngcggcgcuacca <<<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<.<<<.......>>>.>>>>>>>>.... ((((((([.((((]...[..)))).(((((.......))))).....(((((..]....)))))))))))).... Structure of a yeast 48S-AUC preinitiation complex in closed conformation (model py48S-AUC-eIF1); Met-tRNAi 8s8j 2 1798 4.7 RF01960,RF02542,RF01959,RF00177 39193907 0003735 0005840 284590 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacauggauaucugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacuccuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaacuggagggcaagucuggugccagcagccgcgguaauuccagcuccaguagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggucugguuguccgguccgacuuuaugucgcgcacugguuuucaaccggaucuuuccuucuggcuaaccuguacuccuugugggugcaggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcgaaagcucgaauauauuagcauggaauaauggaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauacngucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuucuuaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacncaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaggguugcuggcacuugccgguugacucuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacangucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgaguacaaccuuggccgagaggucuggguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacnagnaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgnccgucgcuaguaccgauugaauggcuuagugaggccucaggauuugcuuagagaagggggcaacuccaucucagagcgaagaaucuggucaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguagguganccugcggaaggaucauua ...<<<<..{.[[[[.>>>><<<<.<<<<<<...<............<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<..<<..<<....<<<................<<.....<<.<<.......>>.>>......>>........<<<<<..<<....>>..>>>>><...<<<<<<......(((((((.<<<....>>>....<<......>>>>>>>>.....>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>..>>>.........>.....<<<<<<<<<.<.......>..>>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>>.........<<<[[.....<.<<...<<<.<<....<.<<<<<<<<<..<<<..<<<.......>>>....>>>.....>>>>>>>>>.>.....<<<<<....<.<...<<.......>>...>.>....>>>.>>...<<<<<.<<.......<<...<.......>..<<<....>>>....>>......>>.>>..>>>.........<<<..<<<<<<<<.....))))))).>>>>>>>>.>>>.....>>....<<<<<<.<<...<<<<..<<<.<<<<<<.<...<<<......>>>......>.>>>>>>.>>>.......<<....>>...>>>>..>>.>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..]]>>...>>.....>>>.>>>.<<<......<<<......>>>....>>>..]]]].}<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<<<<<<<<....>>>>>>.>>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<<.<<<<....>>>>.>>>....>>.......>>>>>>>......<....<<<<<<..........>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<..<...<<<<<<..<...................>...>>>>>>...>..>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((....[[[..))))((((.((.(((...(.(....(.....(((.(((..((....((....((..........))...)){))......(((.......(((..((...(....(((............{...((.....((.(((.....))).))......))........(((((..((....))..)))))(.(.(.((((......[[[.[[[.(((....))).....(......).)))))..)...).(}((((..((.(....))).)))))...)))...)).)..))).(((....(((....((((((((.......)))))))))))......)))...(((.(((......)))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).)))))......).).....(..(.((((..((....))..)))).)...)....(.(((.(...........)).))......)..(((.([[....(.((((.....((..]])).......)))))).)))..))).))))))..{......((({....(.(.((....((.((.....((((((((((.(.((..(((.......)))....)).)....))))))))))......((.((.......(.((.........)).).......)).))....((.((.((.......(...((.......)).(((....))).....)......)).))...)).........(((..(...((((.....]]].]]].))).)..).))).....))....((..((.((...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)).))...))...))....)).)....((((..........((((.........)))).......))))......<...(((.((.(((...(((((((.(((........))))))))))...)))...((...}))...))...}.))))))).(((......((((....))))....)))...]]]..(((((.(((((((..((..(((((..(((..(((((......((........))........(.(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((.(((....((..(.(((....)))..(.((......)))....)..))....(((((.((..((((..((((((.(((((....)))))..))))))..)))).))..(.(((((.......)))))....)..)))))....)))..)).....).))))).....).))))))..)).)))..))).(...(((((((......((.....(((.((((....)))).)))....)).......)))))))......(....((((((..........))))))....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(..(((((((.(((..(.((..(...((.(((..(....................)..))).))...)..)).)..))).))))))).)..)).))))...).))...)..)..(((((((((....)))))))))>........ Structure of a yeast 48S-AUC preinitiation complex in closed conformation (model py48S-AUC-eIF5); 18S ribosomal RNA 8s8j 3 26 4.7 39193907 28985 cucuaacuauaaaaaucucucuucuc .......................... .......................... Structure of a yeast 48S-AUC preinitiation complex in closed conformation (model py48S-AUC-eIF5); mRNA (5'-R(P*AP*AP*U)-3') 8s8j 1 75 4.7 RF00005 39193907 0030533 559292 agcgccgunncgcagnggaagcgcncagggcucaunacccugaunnnnucggaucgnaaccgngcggcgcuacca <<<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<.<<<.......>>>.>>>>>>>>.... (((((((..((((....[..)))).(((((.......))))).....(((((..]....)))))))))))).... Structure of a yeast 48S-AUC preinitiation complex in closed conformation (model py48S-AUC-eIF5); Met-tRNAi 8s8k 2 1798 4.0 RF01960,RF02542,RF01959,RF00177 39193907 0003735 0005840 284590 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacauggauaucugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacuccuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaacuggagggcaagucuggugccagcagccgcgguaauuccagcuccaguagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggucugguuguccgguccgacuuuaugucgcgcacugguuuucaaccggaucuuuccuucuggcuaaccuguacuccuugugggugcaggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcgaaagcucgaauauauuagcauggaauaauggaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauacngucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuucuuaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacncaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaggguugcuggcacuugccgguugacucuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacangucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgaguacaaccuuggccgagaggucuggguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacnagnaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgnccgucgcuaguaccgauugaauggcuuagugaggccucaggauuugcuuagagaagggggcaacuccaucucagagcgaagaaucuggucaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguagguganccugcggaaggaucauua ...<<<<<.{.[[[[>>>>><<<<.<<<<<<...<.<...<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<..<<..<<....<<<................<<.....<<.<<<.....>>>.>>......>>........<<<<<..<<....>>..>>>>><...<<<<<<......(((((((.<<<....>>>..............>>>>>>.....>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>..>>>..>....>.>.....<<<<<<<<<<..<....>..>>>>>>>.>>>......<<..<...........>..>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>>>>>.........<<<[[.....<.<<...<<<.<<....<<<<<<<<<<<.<<<<..<<<.......>>>....>>>>....>>>>>>>>>>>....<<<<<<......<<..<<.......>>..>>......>>>>>>...<<<<<.<<.......<<...<.......>..<<<....>>>....>>......>>.>>..>>>.........<<<..<<<<<<<<.....))))))).>>>>>>>>.>>>.....>>....<<<<<<.<<...<<<<..<<<.<<<<<<.<...<<<......>>>......>.>>>>>>.>>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..]]>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..]]]].}<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<......>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<<<<<<<<....>>>>>>.>>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<<.<<<<....>>>>.>>>....>>.......>>>>>>>......<....<<<<<<..........>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<..<...<<<<<<..........................>>>>>>...>..>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))((((.((.(((...(.(....(.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((............{...((.....((.(((.....))).))......))........(((((..((....))..)))))(.(.((((((......[[[.[[[.(((....))).....(......).)))))).)...).(}((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.(((......)))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).)))))......).).....((.((((((..((....))..))))))..))....(.(((.(...........)).))......)..(((.([[....(.((((.....((..]])).......)))))).)))..))).))))))..{......((({....(.(.((...(((.((....(((((((((((.((.(..(((.......)))....).))....)))))))))))......((((.......(.((.........)).).......)))).....((.((.((.......(...((.......)).(((....))).....)......)).))...)).........(((..(....(((.....]].]]]].)))....).))).....))....((..((.((...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)).))...))...)))...)).)....((((..........(((...........))).......))))......<...(((.((.(((...(((((((.(((........))))))))))...)))...((...}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((..(((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....((..(.(((....)))..(.((......)))....)..))....(((((.((..((((..((((((((((((....)))))).))))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))..))).(...(((((((......((.....(((.((((....)))).)))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..((((..(...(((((...(....................)...)))))...)..))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>........ Structure of a yeast 48S-AUC preinitiation complex in swivelled conformation (model py48S-AUC-swiv-eIF1); 18S ribosomal RNA 8s8k 1 75 4.0 RF00005 39193907 0030533 559292 agcgccgunncgcagnggaagcgcncagggcucaunacccugaunnnnucggaucgnaaccgngcggcgcuacca <<<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((....[..)))).(((((.......))))).....(((((..]....)))))))))))).... Structure of a yeast 48S-AUC preinitiation complex in swivelled conformation (model py48S-AUC-swiv-eIF1); Met-tRNAi 8s9u F 37 2.77 1148 acugaaacuguaguagaaccaaucggggucgucaaua ..................................... ..................................... CRISPR-Cas type III-D effector complex bound to a target RNA; CRISPR RNA 8s9u G 33 2.77 1148 uauugacgaccccgauugguucuacuacaaacg ................................. ................................. CRISPR-Cas type III-D effector complex bound to a target RNA; Target RNA 8s9v F 37 3.0 38637512 1148 acugaaacuguaguagaaccaaucggggucgucaaua ..................................... ..................................... CRISPR-Cas type III-D effector complex bound to a self-target RNA in the pre-cleavage state; CRISPR RNA 8s9v G 34 3.0 38637512 1148 uauugacgaccccgauugguucuacuacaguuuc .................................. .................................. CRISPR-Cas type III-D effector complex bound to a self-target RNA in the pre-cleavage state; Self-target RNA 8s9x F 37 3.44 38637512 1148 acugaaacuguaguagaaccaaucggggucgucaaua ..................................... ..................................... CRISPR-Cas type III-D effector complex bound to self-target RNA in a post-cleavage state; CRISPR RNA 8s9x G 19 3.44 38637512 1148 uauugacgaccccgauugg ................... ................... CRISPR-Cas type III-D effector complex bound to self-target RNA in a post-cleavage state; Self-target RNA 8sa2 A 210 3.1 RF00174 URS000080E34D_119072 37534568 0031419 119072 gguuaaagccuuauggucgcuaccauugcacuccgguagcguuaaaagggaagacgggugagaaucccgcgcagcccccgcuacugugagggaggacgaagcccuaguaagccacugccgaaaggugggaaggcaggguggaggaugagucccgagccaggagaccugccauaagguuuuagaaguucgccuucggggggaaggugaaca ..<<<<<<<<<<<<<<<<<<<<.<..........>.>>>>>.....<<<.....<<<<.......>>>>.((<<......>>.<<<...<<<<.........<<......<<<.<<<<<....>>>>>...>>>..>>...........>>>>..))>>>....>>>>>>>>>>>>>>>>>>..<<<<<<<<<.......>>>>>>>>>. ...(((((.(((((((((((((.....(....)...))))).....((....(.((((.......)))))[[((......)).(((...((((..........(......(((.(((((....)))))...))).).............))))..]]))).....)))))))))).)))))...((((.((((.......)))).)))). Adenosylcobalamin-bound riboswitch dimer, form 1; adenosylcobalamin riboswitch form 1 8sa2 B 210 3.1 RF00174 URS000080E34D_119072 37534568 0031419 119072 gguuaaagccuuauggucgcuaccauugcacuccgguagcguuaaaagggaagacgggugagaaucccgcgcagcccccgcuacugugagggaggacgaagcccuaguaagccacugccgaaaggugggaaggcaggguggaggaugagucccgagccaggagaccugccauaagguuuuagaaguucgccuucggggggaaggugaaca ..<<<<<<<<<<<<<<<<<<<<.<..........>.>>>>>.....<<<.....<<<<.......>>>>.((<<......>>.<<<...<<<<.........<<......<<<.<<<<<....>>>>>...>>>..>>...........>>>>..))>>>....>>>>>>>>>>>>>>>>>>..<<<<<<<<<.......>>>>>>>>>. ..((((((((((((((((((((..............))))).....((....(.((((.......)))))[[((......)).(((...((((..........(......(((.(((((....)))))...))).).............))))..]]))).....)))))))))))))))))..(((((((((.......))))))))). Adenosylcobalamin-bound riboswitch dimer, form 1; adenosylcobalamin riboswitch form 1 8sa3 A 210 3.0 RF00174 URS000080E34D_119072 37534568 0031419 119072 gguuaaagccuuauggucgcuaccauugcacuccgguagcguuaaaagggaagacgggugagaaucccgcgcagcccccgcuacugugagggaggacgaagcccuaguaagccacugccgaaaggugggaaggcaggguggaggaugagucccgagccaggagaccugccauaagguuuuagaaguucgccuucggggggaaggugaaca ..<<<<<<.<<<<<<<<<<<<<..............>>>>>.....<<<.....<<<<.......>>>>.((<<......>>.<<<...<<<<.........<<......<<<.<<<<<....>>>>>...>>>..>>...........>>>>..))>>>....>>>>>>>>>>>.>>>>>>..<<<<<<<.<.......>.>>>>>>>. ...(((((.(((((((((((((.....(....)...))))).....((....(.((((.......)))))[[((......)).(((...((((..........(......(((.(((((....)))))...))).).............))))..]]))).....)))))))))).)))))...((((((((.........)))))))). Adenosylcobalamin-bound riboswitch dimer, form 2; adenosylcobalamin riboswitch form 2 8sa3 B 210 3.0 RF00174 URS000080E34D_119072 37534568 0031419 119072 gguuaaagccuuauggucgcuaccauugcacuccgguagcguuaaaagggaagacgggugagaaucccgcgcagcccccgcuacugugagggaggacgaagcccuaguaagccacugccgaaaggugggaaggcaggguggaggaugagucccgagccaggagaccugccauaagguuuuagaaguucgccuucggggggaaggugaaca ..<<<<<<<<<<<<<<<<<<<<<<..........>>>>>>>.....<<<.....<<<<.......>>>>.((<<......>>.<<<...<<<<.........<<......<<<.<<<<<....>>>>>...>>>..>>...........>>>>..))>>>....>>>>>>>>>>>>>>>>>>..<<<<<<<<<.......>>>>>>>>>. ...(((((.((((((((((.((..............)).)).....((....(.((((.......)))))[[((......)).(((...((((..........(......(((.(((((....)))))...))).).............))))..]]))).....)))))))))).))))).....(((((...........)))))... Adenosylcobalamin-bound riboswitch dimer, form 2; adenosylcobalamin riboswitch form 2 8sa4 A 189 3.1 RF00174 URS000080E34D_119072 37534568 0031419 119072 gguuaaagccuuauggucgcuaccauugcacuccgguagcguuaaaagggaagacgggugagaaucccgcgcagcccccgcuacugugagggaggacgaagcccuaguaagccacugccgaaaggugggaaggcaggguggaggaugagucccgagccaggagaccugccauaagguuuuagaaguaca ....<<<<<<<<<<<<<<<<<<..............>>>>>.....<<<.....<<<<.......>>>>.((<<......>>.<<<...<<<<.......<.........<<<.<<<<<....>>>>>...>>>....>..........>>>>..))>>>....>>>>>>>>>>>>>>>>......... ..(.((((((((((((((((((..............))))).....((....(.((((.......)))))[[((......)).(((...((((.................(((.(((((....)))))...)))...............))))..]]))).....))))))))))))))).)....... Adenosylcobalamin-bound riboswitch dimer, form 3; adenosylcobalamin riboswitch form 3 8sa4 B 47 3.1 URS000080E34D_119072 37534568 0031419 119072 gguuaaagccagguuuuagaaguucgccuucggggggaaggugaaca ..<<<...........>>>...<<<<<<<<.......>>>>>>>>.. ...(.............)....((((((((.......)))))))).. Adenosylcobalamin-bound riboswitch dimer, form 3; adenosylcobalamin riboswitch form 3 8sa5 A 210 3.5 RF00174 URS000080E34D_119072 37534568 0031419 119072 gguuaaagccuuauggucgcuaccauugcacuccgguagcguuaaaagggaagacgggugagaaucccgcgcagcccccgcuacugugagggaggacgaagcccuaguaagccacugccgaaaggugggaaggcaggguggaggaugagucccgagccaggagaccugccauaagguuuuagaaguucgccuucggggggaaggugaaca ..<<<<<<<<<<<<<<<<<<<<<............>>>>>>.....<<<.....<<<<.......>>>>.((<<......>>.<<<...<<<<.......<<<<......<<<.<<<<<....>>>>>...>>>.>>>>..........>>>>..))>>>....>>>>>>>>>>>>>>>>>>..<<<<<<<<<.......>>>>>>>>>. ...((((.((((((((((.((((............)))).).....((....(.((((.......)))))[[((......)).(((...((((.................(((.(((((....)))))...)))...............))))..]]))).....))))))))))).))))...(((((((((.......))))))))). Adenosylcobalamin-bound riboswitch dimer, form 4; adenosylcobalamin riboswitch form 4 8sa5 B 135 3.5 RF00174,RF01689,RF01482 URS000080E34D_119072 37534568 0031419 0010468,0045893,0046336 119072 gguuaaagccuuauggucgcuuaaaagggaagacgggugagaaucccgcgcagcccccgcuacugugagggaggacccgagccaggagaccugccauaagguuuuagaaguucgccuucggggggaaggugaaca ..<<<<<<<<<<<<<<<........<<<.....<<<<.......>>>>.((<<......>>.<<<....<<.....>>..))>>>....>>>>>>>>>>>>>>>>>>..<<<<<<<<<.......>>>>>>>>>. ...(((((((((((((.........((....(.((((.......)))))[[((......)).(((...(........)..]]))).....)).)))))))))))))...(((((((((.......))))))))). Adenosylcobalamin-bound riboswitch dimer, form 4; adenosylcobalamin riboswitch form 4 8sa6 A 210 5.3 RF00174 URS000080E34D_119072 37534568 0031419 119072 gguuaaagccuuauggucgcuaccauugcacuccgguagcguuaaaagggaagacgggugagaaucccgcgcagcccccgcuacugugagggaggacgaagcccuaguaagccacugccgaaaggugggaaggcaggguggaggaugagucccgagccaggagaccugccauaagguuuuagaaguucgccuucggggggaaggugaaca ..<<<<<.<<<<<<<<.<<<<<<<..........>>>>>>>.....<<......<<<<.......>>>>.((<<......>>.<<<...<<<<...<...<<.........<<..<<<<....>>>>....>>....>>...>......>>>>..))>>>.....>>.>>>>>>>>.>>>>>..<<<<<<<<<.......>>>>>>>>>. ...(((((.(((((((.(((((((..........))))))).....(.....(.((((.......)))))[[((......)).(((...((((...(...(.(........((.((..(.....).))...))....))...)......))))..]])))......).))))))).)))))....(((((((.........))))))).. apo form of adenosylcobalamin riboswitch dimer; apo form of adenosylcobalamin riboswitch dimer 8sa6 B 152 5.3 RF00174 URS000080E34D_119072 37534568 0031419 119072 gguuaaagccuuauggucgcuaccauugcacuccgguagcguuaaaagggaagacgggugagaaucccgcgcagcccccgcuacugugagggcccgagccaggagaccugccauaagguuuuagaaguucgccuucggggggaaggugaaca ..<<<<<<<<<<<<<<.<<<<<<<..........>>>>>>>.....<<......<<<<.......>>>>.((<<......>>.<<<...<<..>>..))>>>.....>>.>>>>>>>>>>>>>>..<<<<<<<<<.......>>>>>>>>>. ...(((((.(((((((.((((((............)))))).....(........(((.......)))..[[((......)).(((...((()))..]])))......).))))))).)))))....(((.((((.......)))).))).. apo form of adenosylcobalamin riboswitch dimer; apo form of adenosylcobalamin riboswitch dimer 8scb 2 76 2.5 RF00005 URS0000868530_9986 38172604 0030533 9986 gucuccguaguguagcgguuaucacguucgccuaacacgcgaaagguccucgguucgaaaccgggcggaaacacca <<.<<<<..<<<..........>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>.>>.... ((.((((..(((.....[....))).(((((.......))))).....(((((..]....))))))))).)).... Terminating ribosome with SRI-41315; P_tRNA 8scb 3 75 2.5 RF00005 URS000086855F_9986 38172604 0030533 0006412 9986 gcccggauagcucagcuguagagcaucagacuuuuaaucugaggguccaggguucaagucccuguucgggcgcca <<<<<<...<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>.>>>>>>.... (((((((..((((....[..)))).(((((.......))))).....(((((..]....)))))))))))).... Terminating ribosome with SRI-41315; E_tRNA 8scb 5 3530 2.5 RF02543 URS00029156CB_9986 38172604 0003735 0005840 9986 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggaaauguggcguacggaagacccaccccggcgccggggggcccaaguccuucugaucgaggcccagcccguggacggugugagnccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaanggaaaguugaaaagaacuuugaagngngaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcgcgguccggccgugccggcggggcggaucucccgcucccgucggcgggggaccgccccccggccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggccccggcggggaagguggcccgggggccccggguguuacagccccgccccggcagcagcagcucgccgaaucccggggccgagggagcgagacccgugcgccgcgcucuccccccucgggggggccgggccaccccucccacggcgcgaccgcuggggcggacuguccagugcgccccgggcgggucgcgccgucgggcccggggggccacgcgagcgcacggggucggcggcgaugucggcuacccacccgacccnucuugnaacncggaccaaggagunuaacacgugcgcgagucgggggcuacgaaagccgccguggcgcaaugaaggugaaggccggcggcgcgccgccggccgaggugggaucccgaggccuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuagnacccnanagauggugancuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcgaaucggucguccgaccuggguauagnggcgaaagacuaaucgaaccaucuaguagcugguucccuccaaaguuucccucaggauagcuggcgcucuccgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcugguguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcngaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgcuggcagucggcagagcgagaaagagaguggcgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaunuuggugguagunnnaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagnanuugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucagccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccnuauccgcagcaggucuncaaggugaacngccucuggnauguuggaacaanguagguaagggaagucggcaagcnggauccguaacuucnggauaaggauuggcucuaagggcuggcagccgacuuagaacuggugcggaccaggngaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugccnagugcucugaaugucanagugangaaauucaaugaagcgcggguaaacggcgggaguancuaugacucucuuaagguagcnaanugccucnucaucuaauuagugangcgcaugaanggaugancgagnuucccacugunccuaccuacuauccagcgaaaccacngncaagggaacgggcuuggnggaaucagcggngaaagaagacccuguugagcuugacncuagucuggcacggugaagagacguuuuuucacugacccggugaggcgggggggcgagccgggcucucgcuucuggcgccaagcgcccggccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacugnggcgguacaccugucaaacgguancgcaggnnuccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucagnacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggangugucagaaaaguuaccacagngauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuungaugucggnucuuccuaucauugugaagcagaauucaccaagcguungaunnuucacccacuaauagggaacgugngcugggnuuagancgucgugagacagguuaguuuuacccuacugaugnuguguuguugccaugguaauccugcucaguacgagaggaaccgcagnuncanacauuugguguaunugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauagcgccggagccucgguuggccucggauagccggucccccgccgggguccggugcggagagcccuucgucccgggaaacgggcggccggaaagggggccgcccucucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcugcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<...<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>...<<<<<<<<<..<<<<<<<<..<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>...>>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<<....<<<<<<<.<<<<<.<<<<<<<.<<<<<<<<<......>>>>>>>>>>>>>>>>>>>>>>>>>...>>>.>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<.<<<<<<<<<<.<<<<...<<..<<<..<<<<<<<......<<<<<<<<.>>>>>>>>.......>>>>>>>..>>>.........>>>>>>...>>>>>>>>>>.....<<.......>>.........<...<<<<<<..>>>>>>...<.<<..<<<.<<<<<<<<<<<<<<<<<<<<<<<.<<<<..>>>>.>>>>>>.>>>>.>>>>>>>>>>.>>>...>>>>>.>.......>.........>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<<<<...<<<<<<<<<<<<<<..<<<...<<<<.....>>>>.....>>>...<<....>>...<<<<<<<<<<..>>>>>>>>>>..<<<<<...<<<..<<<..(((.[[.>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>>.<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<...<<<.<<<<<<<<<...<<<....<<<..<.<<<..<<<<<<.........>>>>>>>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.........>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<....................]].)))............>>>>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<<<<<...>>>>>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<..<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<.<<<<<<<<<<<.>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<<....>>>>>>>>...<<<<<.....<<<<..<<.<..<..>..>.>>..............<<<<<<<<<..>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>><<<<....>>>>>>)))].....<<<<<<<..<<<..)))))).>>>>>>>>>>.........>>>>..>>>>>>.......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<....<<<<<.................>>>>>..<<<<....<<<<...<<<.<<<<<<<]]].>>>>>..>>.>>>..>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.<<<<<<...<<<<....<<<........<<<<<...<<<<.>>>>..>>>>>.......>>>...<<<..<<<<....<<.<<<<<........>>>>>...>>...>>>>..>>>..............>>>>....>>>>>>.<<<<<.<.............>....<<.<<<<<<<.<<.....<<<<.<..<<<<<.>>>>>..>>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..(((((((((((.....)))))).))))....))))....(((((((((..(.((((((.(((((((((..({((((......)))))....[[(...).(((....}]])))...).)))))))..))))))).)...)))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....((((((((((.(..(((((((.(((((.(((((((.(((((((((..()..)))))))))))))))))))))))))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((..(((((((......((((((((.)))))))).......)))))))..))).........))))))..))))))))))).....((.....{.)).........(.(.((((((()))))))...(.((..(((.(((((((((((((((..((((((.((((..)))).))))))...).))))))))))).)))...))))).)...[.).)........))).)))))...)))))...)))))))).<((((........))))((((((....(((((((((((((..(((..((((.......)))..)..)))...((....))...((((((((((()))))))))))..(((((...(((..(((].[[[.[[[)))..)))....))))).(((((((((.((((......))))))))))).))....)))))))))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)<)))...(((..((.((.......B)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((...(((.((((((((.....((.....((....(((..(((.((.........)).))))))....))...))......))))))...(((((((((.(......))))))))))....))))))))))))..))..((((..(.((.....)).)..))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.....A.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((........}.........].]].]]]............)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...(...(.(((....))).....)....((.((((.((((...)))).)))))).......)....))...(((((........)))))]]((((....(((((...(((((((....)))))))..((((....)))...(...((((((...((((((((((((((((((((((....{{...)))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).)))..)).....((......)).)))).((((.....))))..)))....(((......(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((.)))))..)))))).))(...).......(((((((((.>.(...........)...(((((((....((((.....))))......))))))).].(.(.(((..((((((.(...(......((((....))))......).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....).)....)).))))))).)..))).)))))))...)))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.(((((...(((((.(((((((((.(((((((((..)))))))))...(((((.....((((..((.(..(..)..).))..............(((((((((..)))))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(..((..(.((....{..)).)..)).)(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}.....)))..)))))).......(....(.((((((...((.......))...))))))...)....)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).)......((((((....))).)))...b.))..))).))))).....((((.(.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}..)))))..)).))...))))...)))).((((...((((.....a.......))))...))))..)))...).).)))).(((((.(..((((....(((.........((((.(.((((.))))).))))........)))...(((..(((.....(((((.((........)).))..)))....)))..)))..............))))..)..))))).(((((.(..(.......)..)....((.(((((((.((.....((((.(..(((((.)))))..)))))....))....)))).))).))..))))).. Terminating ribosome with SRI-41315; 28S_rRNA 8scb 7 120 2.5 RF00001 URS000002B0D5_9986 38172604 0003735 0005840 9986 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. Terminating ribosome with SRI-41315; 5S_rRNA 8scb 8 156 2.5 RF00002,RF02540 URS00004B2C76_9986 38172604 0003735 0005840 9986 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauuncaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<<<<....>>>>.....<.<<<......>>.............>>>..>...>>>....<<<..>>><<<<<<<<.......>>>>>>>>.................... .........................................((((((.[[....[)))...].(.(((......]].............)))..)...)))....((....))((((((((.......)))))))).................... Terminating ribosome with SRI-41315; 5.8S_rRNA 8scb 9 1692 2.5 RF01960,RF02542,RF01959,RF00177 URS0002915683_9986 38172604 0003735 0005840 9986 uaccugguugauccugccaguagcaunugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucnuuaaaucaguuauggunccuunggucgccacuuggauaacugugguanuucuagngcuaananaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgccccccguggcggcgacgaccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgaunccggaganggagccugagaaacggcuaccacauccaaggnaggcagcaggcgcgcnaauuacccacucccgacccggggangungugangaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauancguauauuaaaguugcugcaguunaaaagcucguaguungaucuugggagcgggcguccccgccuuuacuuugaaaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagancgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacncaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccguggguggngnugcauggcnguucuuaguugguggagcgauuugucugguuaauuccgauaacgancgagacunuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuncuuagagggacaaguggcguucagccacccgagauugagcaauaacangucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgagnaauucccaguaagugcgggucauaagcuugcguugauunagucccugcccuuuguacacaccgnccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggugcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguancaagguuucnguaggugnnccugcggaaggaucauu ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<....<<....<<<<.......<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<<<....>>>>>>...>>>>....<<<<<...<......>..>>>>>............<<<.<<<<......>>>>>>>...>>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....<<.<<<<<<.<<<....>>>..>>>>>>..>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<.....<<.<.<<....>>.>.>>.<<<<<<.<.......<<...<.......>.<<<<.......>>>>...>>......>.>>>..>>>.......<<.<..<<<<<<<............>>>>>>>.>.>>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<........>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<..........<<.<<<........>>>.>>........>>>...<<.<<<..<<<<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<.....<<<...<<<....>>>..>>>.....>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>...>.>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<...<.<<<<<..........>>>>>>....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<<<<<<<<<<<..>>>>>>>>>.>.>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>........ ...((((..[.[[[..))))(((..(((((.....((..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..((....((((.......((.....((.(((.....))).))......)).........((((...(((((......)))))...))))(...(((((...(......)..)))))........)...(((.((((......)))))))...))))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).......((.((((((.(((....)))..))))))..))....(.((..(...........)..))......)..((((([[......(.((.....((..]])).......)).).)))))..)))))..)))..[......(.([[...(.(.((...(((.((.....((.(.(((..))).).)).(..(((.(........(..((.......)).(((.......)))....).......).)))....).......((.(..(.((.((............)).)).).).))....))...((((.((..(...(((...((..((((((((...((........))......))))))))..)).......((....))....)))..)..))..)))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.(((........))))))))).)..)))...((..]]))...))...].))))).).(((......((.(....).))....)))...]]].]((((..(((((((..((..((.((..(((..(((((.......(........)...........(((((.(....(((.(........((..((........)).).).......))))...((.(((...(.((((((....((..(((((....)))..(.((......)))...))..))....(((...(...((.(..((((..(.(((...(((....)))..))))...))))..).))..).....(((((.....)))))........)))....))).))).....).))))).....).)))))...)).)))..))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....(((((..........))))).....)..)..)).)).....((((((((.......))))))))......))...))))))).)).))..(.(..((.(..((((.((..(.((((((((.(((..((((.((...(((((.(((((.(((..))).)))))...)))))...)).))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}....... Terminating ribosome with SRI-41315; 18S_rRNA 8scb hh 11 2.5 38172604 9606 caaaguuuaag ........... ........... Terminating ribosome with SRI-41315; mRNA 8skq A 12 1.35 URS000291569C_32630 37638886,21460447 32630 gngaauncgnga ............ ............ RNA oligonucleotide containing an alpha-(L)-threofuranosyl nucleic acid (TNA); TNA-containing RNA oligonucleotide 8sq9 P 32 2.9 URS0002617797_2901879 37890482 2901879 guagcaugcuacgucauucuccacgcgaagca ................................ ................................ SARS-CoV-2 replication-transcription complex bound to nsp9 and UMPCPP, as a pre-catalytic NMPylation intermediate; Primer RNA 8sq9 T 35 2.9 URS00026177A3_2901879 37890482 2901879 ucaugcuucgcguggagaaugacguagcaugcuac ................................... ................................... SARS-CoV-2 replication-transcription complex bound to nsp9 and UMPCPP, as a pre-catalytic NMPylation intermediate; Template RNA 8sqj P 32 3.06 URS0002915682_2901879 37890482 2901879 agcaugcuacgucauucuccacgcgaagcaug ................................ ................................ SARS-CoV-2 replication-transcription complex bound to RNA-nsp9, as a noncatalytic RNA-nsp9 binding mode; Primer RNA 8sqj T 35 3.06 URS00026177A3_2901879 37890482 2901879 ugucaugcuucgcguggagaaugacguagcaugcu ................................... ................................... SARS-CoV-2 replication-transcription complex bound to RNA-nsp9, as a noncatalytic RNA-nsp9 binding mode; Template RNA 8sqk P 32 3.01 URS0002915685_2901879 37890482 2901879 agcaugcuacgucauucuccacgcgaagcaug ................................ ................................ SARS-CoV-2 replication-transcription complex bound to RNA-nsp9 and GDP-betaS, as a pre-catalytic deRNAylation/mRNA capping intermediate; Primer RNA 8sqk T 35 3.01 URS00029156E0_2901879 37890482 2901879 ugucaugcuucgcguggagaaugacguagcaugcu ................................... ................................... SARS-CoV-2 replication-transcription complex bound to RNA-nsp9 and GDP-betaS, as a pre-catalytic deRNAylation/mRNA capping intermediate; Template RNA 8ssw C 23 2.4 URS000080DD89_32630 32630 caaggucauucgcaagaguggcc ....................... ....................... Crystal structure of DEAD-box RNA helicase DDX3X in complex with ADP at pre-unwound state; RNA (28-MER) 8ssw D 23 2.4 32630 gucauucgcaagaguggccuugc ....................... ....................... Crystal structure of DEAD-box RNA helicase DDX3X in complex with ADP at pre-unwound state; RNA (28-MER) 8swb B 20 2.0 URS00021ED8FD_9606 9606 uggcgagugggugagugagg .................... .................... RNase H complex with streopure ASO and RNA; RNA (5'-R(*UP*GP*GP*CP*GP*AP*GP*UP*GP*GP*GP*UP*GP*AP*GP*UP*GP*AP*GP*G)-3') 8swc B 20 2.68 URS00021ED8FD_9606 9606 uggcgagugggugagugagg .................... .................... RNase H complex with ASO (OOO) and RNA; RNA (5'-R(*UP*GP*GP*CP*GP*AP*GP*UP*GP*GP*GP*UP*GP*AP*GP*UP*GP*AP*GP*G)-3') 8swg A 14 1.5 37920395 32630 nnnnacuuaagucg .............. .............. RNA duplex bound with GpppA dinucleotide ligand; RNA (5'-R(*(LCC)P*(LCC)P*(LCC)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*G*(GA3))-3') 8swg B 14 1.5 37920395 32630 nnnnacuuaagucg .............. .............. RNA duplex bound with GpppA dinucleotide ligand; RNA (5'-R(*(LCC)P*(LCC)P*(LCC)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*G*(GA3))-3') 8swo A 14 1.64 37920395 32630 nnnnacuuaagucg .............. .............. GpppA dinucleotide ligand binding to RNA UC template; RNA (5'-R(*(TLN)P*(LCC)P*(LCC)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*G*(GA3))-3') 8swo B 14 1.64 37920395 32630 nnnnacuuaagucg .............. .............. GpppA dinucleotide ligand binding to RNA UC template; RNA (5'-R(*(TLN)P*(LCC)P*(LCC)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*G*(GA3))-3') 8sx5 A 14 1.95 37920395 32630 nnnnacuuaagucg .............. .............. GpppA dinucleotide binding to RNA CU template; RNA (5'-R(*(TLN)P*(LCC)P*(LCC)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*G*(GA3))-3') 8sx5 B 14 1.95 37920395 32630 nnnnacuuaagucg .............. .............. GpppA dinucleotide binding to RNA CU template; RNA (5'-R(*(TLN)P*(LCC)P*(LCC)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*G*(GA3))-3') 8sx6 A 14 1.45 37920395 32630 nnnnacuuaagucg .............. .............. RNA duplex bound with GMP and AMP monomers; RNA (5'-R(*(TLN)P*(LCC)P*(LCC)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*GP*G)-3') 8sx6 B 14 1.45 37920395 32630 nnnnacuuaagucg .............. .............. RNA duplex bound with GMP and AMP monomers; RNA (5'-R(*(TLN)P*(LCC)P*(LCC)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*GP*G)-3') 8sxl A 14 1.9 URS0002681414_32630 37920395 32630 nnnnacuuaagucu .............. .............. RNA UU template binding to AMP monomer; RNA (5'-R(*(TLN)P*(TLN)P*(LCA)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*U)-3') 8sxl B 14 1.9 URS0002681414_32630 37920395 32630 nnnnacuuaagucu .............. .............. RNA UU template binding to AMP monomer; RNA (5'-R(*(TLN)P*(TLN)P*(LCA)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*U)-3') 8sy1 A 14 1.76 37920395 32630 nnnnacuuaagucg .............. .............. RNA duplex bound with imidazolium bridged GA dinucleotide; RNA (5'-R(*(TLN)P*(LCC)P*(LCC)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*G*(GMA))-3') 8sy1 B 14 1.76 37920395 32630 nnnnacuuaagucg .............. .............. RNA duplex bound with imidazolium bridged GA dinucleotide; RNA (5'-R(*(TLN)P*(LCC)P*(LCC)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*G*(GMA))-3') 8sy1 C 14 1.76 37920395 32630 nnnnacuuaagucg .............. .............. RNA duplex bound with imidazolium bridged GA dinucleotide; RNA (5'-R(*(TLN)P*(LCC)P*(LCC)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*G*(GMA))-3') 8sy1 D 14 1.76 37920395 32630 nnnnacuuaagucg .............. .............. RNA duplex bound with imidazolium bridged GA dinucleotide; RNA (5'-R(*(TLN)P*(LCC)P*(LCC)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*G*(GMA))-3') 8syl a 1528 2.9 RF00177,RF01959,RF02542,RF01960 URS00000ABFE9_562 37537169 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugccggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauc ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<........>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<..>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>.............>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<..<.<<<<<<<........>>>>>>>>...>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((((..........)))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....(((.((((.......)))).))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((((())))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((.(((....))).)))....(.....)..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Cryo-EM structure of the Escherichia coli 70S ribosome in complex with amikacin, mRNA, and A-, P-, and E-site tRNAs; 16S Ribosomal RNA 8syl w 74 2.9 RF00005 URS00005AA258_562 37537169 0030533 0006412 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<......>>>><<<<<<<.....>>>>>>.>...<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[..)))).((((.........)))).....(((((..]....)))))))))))).... Cryo-EM structure of the Escherichia coli 70S ribosome in complex with amikacin, mRNA, and A-, P-, and E-site tRNAs; phenylalanine tRNA 8syl x 76 2.9 RF00005 URS000041AF00_562 37537169 0030533 0006412 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Cryo-EM structure of the Escherichia coli 70S ribosome in complex with amikacin, mRNA, and A-, P-, and E-site tRNAs; P-site initiator tRNA 8syl y 74 2.9 RF00005 URS00005AA258_562 37537169 0030533 0006412 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<......>>>><<<<<<.......>>>>>.>...<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[..)))).((((.........)))).....(((((..]....)))))))))))).... Cryo-EM structure of the Escherichia coli 70S ribosome in complex with amikacin, mRNA, and A-, P-, and E-site tRNAs; phenylalanine tRNA 8syl v 12 2.9 37537169 2681598 aaaauguucuaa ............ ............ Cryo-EM structure of the Escherichia coli 70S ribosome in complex with amikacin, mRNA, and A-, P-, and E-site tRNAs; M-F-Stop mRNA 8syl A 2845 2.9 RF02541 URS00004B0F34_562 37537169 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagcgucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcgcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<........>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<..>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<..>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<....<<......<<<<<<<<....>>>>>>>>...>>..............>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>.(<<...<<<<<<<...<<<<<<.......>>>>>>.....<<)..(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......((((.((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))).))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((..........))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((.(...((.((((.....))))..))...).)).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{..()....)))..))))).))...........]]].)...))))))))))...)))))))((((((((()))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((.(.(..(...(.........((..(...(.........((.((......)).))......).............)..)))...)..).).)))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...(.((..((((..{.))))..)).).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Cryo-EM structure of the Escherichia coli 70S ribosome in complex with amikacin, mRNA, and A-, P-, and E-site tRNAs; 23S Ribosomal RNA 8syl B 120 2.9 RF00001 URS00005C6868_562 37537169 0003735 0005840 562 ugccuggcggcaguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). Cryo-EM structure of the Escherichia coli 70S ribosome in complex with amikacin, mRNA, and A-, P-, and E-site tRNAs; 5S Ribosomal RNA 8t2p A 135 5.0 URS0002915697_32630 38207080 32630 gaccaaucugcccucagagcucgagaacaucuucggaugcagaggaggcaggcuucgguggcgcgauagcgccaacguccucaaccuccaaugcaucccaccacaugaugaugccugaagagccuugguuuuuug .<<<<<...<<..<<<<.<<.......<<<<...<<<<<<<..<<<<<.<<<...<<.<<<<<<....>>>>>>.>>.>>>...>>>>>..>>>>>>>........>>>>..>>>>>>...>>.>>>>>...... ..((((...(((.((((.((.......((((((.(((((((..(((((.(((...((.((((((....)))))).)).)))...)))))..)))))))....).).))))..)))))).).)).))))....... 5TU-t1 - heterodimeric triplet polymerase ribozyme; RNA (135-MER) 8t2p B 152 5.0 URS00029156B9_32630 38207080 32630 ggaucuucucgaucuaacaaaaaagacaaaucugccacaaagcuugagagcaucuucggaugcagaggcggcagccuucgguggcgcgauagcgccaacguucucaacuaugacacgcaaaacgcgugcuccguugaauggaguuuaucaug <<<<.......>>>>................(((((.......<<<<<<<<<<<....>>>>>.<<<<.)))))>>>><<.<<<<<<....>>>>>>.>>.>>>>>>.<<<<<<<<<<.....>>>>><<<<<.....>>>>>....>>>>> .(((.......))).................[[[[[.....(.(((((((((((....))))).((((.]]]]]))))((.((((((....)))))).)).)))))))((((((((((.....)))))(((((.....)))))....))))) 5TU-t1 - heterodimeric triplet polymerase ribozyme; RNA (152-MER) 8t2r B 545 3.1 RF00029 URS0002915678_39491 37993708 0000373 39491 guuugcgcgccaugggcgcgcucuaacggguguaagucccgaacaugcccagguagugggaaauguauagccgaacagcaagggugucuacugugagguggaaucugaaggaagcuguaagcgaaucucugguccgacggacagaaaucgcauauaaggcuaggcuucgagugauaagcuggcaaagaacagugaagucuaauaacuaccaguagaagcagaguaaaugcggcggauauauggagagaaagagcgugcaccuuaagcguggaggucucacagaggugccuaguaacaacgaacugugagaagucagccgagcccauaguagugaagaagucucuguaauggggauggagcgaaggggcgaacaaucaaucaugucucguauugcagaaaugacaacaucugccguaaccaaucggguaaaagguggucaaaucaagcgagacggaaagguaaguugauugaaccgccguauacggaaccguacguacgguggugugagaggucggaauuucgaaauucuuccuacucgauugaau .....<<<<<...<<<<<<<<<<<..<<<<.......>>>>.<<<<.<<<..(((((>>>..>>>>...<<....<<<<..<<<<.<<<<<<....>>>>>>>>>>.......>>>>...>>...<<<<<<<<<<<...........<<<<<......<<<..<<<<<....<<<..<<<<........>>>>...>>>.....))))).....>>>>>..>>>...>>>>>>>>>>...>>>>>>...>>>>>>>>>.>>....>>>>>...<<<<<<<<<<<<..>>>.<......>...>>>>>>>>..>....<..<<<<......<<......<<<<<<.....>>>>>>...>>....>>>>>..<<<<<<<<..<...<<<<.<<<<.<<..<<<<..<<<<..<<<........>>>......>>>>>>>>..>>..>>>>.>>>>...>....>>>>>>>>.<<<<<<<<<<<<<....>>>..>>>>>>>>>>..<<<<<<..<<<<<<<..>>>>>>>.>>>.>>>........ ..[<.((((({..(((((((((((..((((.......)))).((((.(((..[[.[[)))..))))...((....((((..((((.((((((....))))))))))...>}..))))...))...(((((((((((...........(((((.....[(((..(((((....(((..((((.]......))))...))).....]].]].....)))))..))).{.))))))))))...))))))...))))))))).))...])))))(...(((((((((((()))).((....))...))))))))...)......((((.(....((......((((((.....))))))...))...)))))...((((((((......((((.((((.((..((((..((((..(((........)))......))))))))..))..)))).))))........)))))))).(((((((((((((....)))..))))))))))..((((((..(((((((()))))))).))).)))...}.... Structure of a group II intron ribonucleoprotein in the pre-ligation (pre-2F) state; Intron 8t2t B 537 3.0 RF00029 URS0002617790_39491 37993708 0000373 39491 guuugcgcgccaugggcgcgcucuaacggguguaagucccgaacaugcccagguagugggaaauguauagccgaacagcaagggugucuacugugagguggaaucugaaggaagcuguaagcgaaucucugguccgacggacagaaaucgcauauaaggcuaggcuucgugauaagcuggcaaagaacagugaagucuaauaacuaagcagaguaaaugcggcggauauauggagagaaagagcgugcaccuuaagcguggaggucucacagagguugccuaguaacaacgaacugugagaagucagccgagcccauaguagugaagaagucucuguaauggggauggagcgaaggggcgaacaaucauaaugucucguauugcagaaaugacaacaucugccguaaccaaucggguaaaagguggucaaaucaagcgagacggaaaggauugauugaaccgccguauacggaaccguacguacgguggugugagaggucggaauuucucaauuaagagaaauucuuccuacucgau .....<<<<<...<<<<<<<<<<<..<<<<.......>>>>.<<<<.<<<....(((>>>..>>>>...<<....<<<<..<<<<.<<<<<<....>>>>>>>>>>.......>>>>...>>...<<<<<<<<<<<...........<<<<<......<<<..<<<<...<<<..<<<<........>>>>...>>>.....)))>>>>..>>>...>>>>>>>>>>...>>>>>>...>>>>>>>>>.>>....>>>>>...<<<<<<<<<<<<<.>>>>.<......>...>>>>>>>>..>....<..<<<<......<<......<<<<<<.....>>>>>>...>>....>>>>>..<<<<<<...<.<.<<<<.<<<<.<<..<<<<..<<<<...<<........>>.......>>>>>>>>..>>..>>>>.>>>>..>>...>>>>>>.<<<<<<<<<<<<<....>>>..>>>>>>>>>>..<<<<<<..<<<<<<<<<<......>>>>>>>>>>.>>>.>>>... ..[<.(..(({..(((((((((((..((((.......)))).((((.(((....[.[)))..))))...((....((((..((((.((((((....))))))))))...>}..))))...))...(((((((((((.(.....)...(((((.....[(((..((((...(((..((((.]......))))...))).....].]))))..)))...))))))))))...))))))...))))))))).))...]))..)(...((((..((((((.)))).((....))...))..))))...)(.....((((.(....((......((((((.....))))))...))...)))))...((((((.....(..(((.((((.((..((((..((((..(............)......))))))))..))..)))).)))...)....)))))).(((((((((((((....)))..))))))))))..((((((..((((((((((......)))))))))).))).)))..) Structure of a group II intron ribonucleoprotein in the post-ligation (post-2F) state; RNA (537-MER) 8t2x B5 1782 2.46 RF01960,RF02542,RF01959,RF00177 0003735 0005840 4932 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacncaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggcnguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgagnaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuucnguaggugnnccugcggaaggaucauu ...<<<<<.{.((((>>>>><<<<.<<<<<<...<.<...<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<..<<..<<....<<<..................<.....<<.<<.......>>.>>......>.........<<<<<............>>>>><...<<<<<<.......((.............................>>>>>>.....>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<<<<<<....>>>>...>>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>..>>>..>....>.>.....<<..<<....<.......>.....>>...>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>>.........<<<[[.....<.<<...<<<.<<....<<<<<<.<<..................>>.>>>>>>.....<<<.<.........<...........>.........>.>>>....<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........<<.....<.<............)).....>.>....>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..]]>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..)))).}<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<<<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<..<<..<<<<..<<<<<.<.<<<<<..>>>>>.>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>........>>>>....>>>.>>>...>.>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>......<....<<<<<<..........>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<....<.<.<<........>>.>.>....>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>........ ...((((..[.[[[..))))((((.((((((...(.(....(.....(((.(((..((....((....((..........))...)){))......(((.......(((...(..((....(((..................((....((.(((.....))).)).....)).........(((((............)))))(.(.(((.((......[.[.[.[.(.(....).).....(......).)).))).)...).(.((((...(((..).))..)))))...)))...)))...))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(..(....)..)...)))))).).....(.(((...((((.}...))).)))))......).).....(....(.....(......).....).....)....(.(.(.(...........))..)......)..((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(.(.(.....((((((.((.(..............).)).))))))......((((.............(.....)...........)))).....(((((.((........(..((.......)).(((.....)))....).......)).))..))).........((.....(..(.......]..]].]...)..)....))......)...(((.(((..(...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)..)))..))..)).)...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((.......(........)...........((((..(....(((((........((.(((........))).))......)))))...((.(((...(.((((((....((..((((......))..(.((......)))...))..))....((((..((..(((...(((((..(.((((..)))).)....)))))...))).))..(.((((((.....))))))....)...))))....))).))).....).))))).....)..))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.((...(.((..(...((.(..(.(.((.((.(....).)).)).)..).).))...)..)).)...)).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>....... Hypomethylated yeast 80S bound with cycloheximide, P-site tRNA, A-site tRNA, messenger RNA and eIF5A, PRE; 18S rRNA 8t2x A1 3216 2.46 RF02540,RF02541,RF02543 0003735 0005840 4932 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaugguguuuuguauuucacuggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugnaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucgggacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauunaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagcnaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauagaggguguagaauaagugggagcuucggcgccagugaaauaccacuaccuuuauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucugunaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuungaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggaunnuucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[...<.......<<.<<<<<<...>>>>>>.>>.......>.....<<<<<<.<<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<.............<..>........<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<..........>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<....<<.<<<<<<<.....<<<....<<<..<.<<<<...............>>>>.>..>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>..>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>......................>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>>..<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>.........<<<<..........>>>>.....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<......<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>............>>.>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<.<<<<<<<<<<<...>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<..<<<.....<<<<....>>>>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<<<<<<<<.............<<<......................>>>....>>>>>>.>>>>>>>>>>...<<<<<.....<<<<..<<<..........>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>..>>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<<...<<<<<<<<<<}}}.>>>>>..>>>>>..>>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<....<<<......>>>....>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((...(((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..)))...))....)))))))))))...)....(((((((........))))))).....(((((..[[[.[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.(((((.........................(((((((((((((((((((((((.......(((((((......(((..........))).......))))))).....))))).))))))))))........(((....)))....)))))))).....))))).))))).[((((........))))((((((..(.((((((.((((((..(((..((((.......))))..)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))).((((((......(((....)))..(((.(.((((....((.(.(((.(......((.....((..(.((((...............)))).)..))...)).......).)))...((((.((((.(......))))).))))(..)..)))..)))).).).))..((((.((.((.....)).)).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(.(((.(.(...((.........))....)).....(...(........).).))).)...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))..........((............))......))....))...(((((........)))))]]((((..(((((.....((((....))).....<.((((((...((((.((((((((((((((((((...{{..))))))....(((((....(((((.....(((.....))).....))))).....))))).....(((((((......))))))))))).).))))))).))))(...)....))))))....).......)).))).)))).)))..)).....((......)).)))).((((.....))))..))))..(.(......((((((..((..(....(.......(((((....(.{..).....)))))((.(((((((((((...)))))..)))))).))(...).......(((((((.(.].((.........))...(((((((....((((.....))))......))))))).}.(.(.(((..((((((.....((.....((((....)))).....))..))))..)))))(.(.(.........).).)........((..........(((((.......)))))..)..)....).)....)..))))))).)..)))..))))))...).)))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.(((((...(((((.((((((((..((.(((.((((((((...............((..(.(...))............))......))))).))).))).))....((((.....((((..((((........))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((...(((....{..)))...))).(((....))).))]]].].....((((((..((((.]].]]]))))))))))....)}.....)))..)))))).......(....(.((((((...((.......))...))))))...)....)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).)......((((((....))).)))...>.))..))).)))))....((((((((..((((.(.(((.(......(....).....).))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(((.((..)..).)))..)))))...)))....)))).)))))).))))).. Hypomethylated yeast 80S bound with cycloheximide, P-site tRNA, A-site tRNA, messenger RNA and eIF5A, PRE; 25S rRNA 8t2x A3 121 2.46 RF00001 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Hypomethylated yeast 80S bound with cycloheximide, P-site tRNA, A-site tRNA, messenger RNA and eIF5A, PRE; 5s rRNA 8t2x A4 158 2.46 RF00002 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Hypomethylated yeast 80S bound with cycloheximide, P-site tRNA, A-site tRNA, messenger RNA and eIF5A, PRE; 5.8 S rRNA 8t2x tP 75 2.46 RF00005 URS00021ED942_559292 0030533 0006412 4932 agcgccgugacgcaguggaagcgcgcagggcucauaacccugauguccucggaucgaaaccgagcggcgcuacca <<<<<<<...<<<.......>>>.<<<<<<.......>>>>>.>...<<<<<.......>>>>>>>>>>>>.... (((((((...(((....[..)))..(((((.......))))).....(((((..]....)))))))))))).... Hypomethylated yeast 80S bound with cycloheximide, P-site tRNA, A-site tRNA, messenger RNA and eIF5A, PRE; P site tRNA 8t2x tA 76 2.46 RF00005 0030533 4932 agcgccgugacgcaguaggaagcgcgcagggcucauaacccugauguccucggaucgaaaccgagcggcgcuacca <<<<<<<...<<<........>>>..<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((...(((.[...{..)))..(((((.......)))))....](((((..}....)))))))))))).... Hypomethylated yeast 80S bound with cycloheximide, P-site tRNA, A-site tRNA, messenger RNA and eIF5A, PRE; A site tRNA 8t2x MR 12 2.46 4932 aaaaaugauuaa ............ ............ Hypomethylated yeast 80S bound with cycloheximide, P-site tRNA, A-site tRNA, messenger RNA and eIF5A, PRE; messenger RNA 8t2y B5 1782 2.2 RF01960,RF02542,RF01959,RF00177 0003735 0005840 4932 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacncaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggcnguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgagnaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuucnguaggugnnccugcggaaggaucauu ...<<<<<.{.((((>>>>><<<<.<<<<<<...<.<...<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<..<<..<<....<<<..................<.....<<.<<.......>>.>>......>.........<<<<<............>>>>><...<<<<<<.......((.............................>>>>>>.....>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>..>>>..>....>.>.....<<...<..................>....>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>>.........<<<[[.....<.<<...<<<.<<....<<<<<<.<<..................>>.>>>>>>.....<<<.<.........<...........>.........>.>>>....<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........<<<....<..............)).......>...>>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..]]>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..)))).}<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<.<<<<<..>>>>>.>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<....<...<<........>>...>....>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>........ ...((((..[.[[[..))))((((.((((((...(.(....(.....(((.(((..((....((....((..........))...)){))......(((.......(((...(..((....(((..................((....((.(((.....))).)).....)).........(((((............)))))(.(.(((.((......[.[.[.[.(.(....).).....(......).)).))).)...).(.((((...(((..).))..)))))...)))...)))...))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(..(....)..)...)))))).).....(.(((...((((.}...))).)))))......).).....(....(.....(......).....).....)....(.(.(.(...........))..)......)..((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(.(.(.....((((((.((.(..............).)).))))))......((((.............(.....)...........)))).....(((((.((........(..((.......)).(((.....)))....).......)).))..))).........((.....(..(.......]..]].]...)..)....))......)...(((.(((..(...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)..)))..))..)).)...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((.......(........)...........((((..(....(((((........((.(((........))).))......)))))...((.(((...(.((((((.(..((..((((......))..(.((......)))...))..))....((((..((..(((...(((((..(.((((..)))).)....)))))...))).))..(.((((((.....))))))....)...)))).)..))).))).....).))))).....)..))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.((...(.((..(...((((..(.(.((.((((....)))).)).)..).))))...)..)).)...)).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>....... Hypomethylated yeast 80S bound with cycloheximide, P-site tRNA, and A-site tRNA, messenger RNA, PRE; 18S rRNA 8t2y A1 3159 2.2 RF02540,RF02541,RF02543 0003735 0005840 4932 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........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..<<<..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<.<<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<.........................<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<..........>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<...<<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>>.<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<....<<.<<<<<<<.....<<<....<<<..<.<<<<...............>>>>.>..>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>..>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>......................>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>>..<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<..........>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<......<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..[[[..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>............>>.>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<...............>>>>><<.<<<<<<<<<<<...>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<..<<<<<<.<.....>.>>>>>>...<<<<<.....<<<<..<<<..........>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))......<<<<<<<..<<<<.))))))>>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>..>>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<<...<<<<<<<<<<]]].>>>>>..>>>>>..>>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<....<<<......>>>....>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<.<..<<<<<......>>>>>..>>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((.((((.((((((((...({((((......)))))[[(...).(((....}]])))....))))))))...)))).))....)))))))))))...)....(((((((........))))))).....(((((..[[[.[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((........................(((((((((((((((((((((((.......(((((((......(((..........))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))).((((((......(((....)))..(((.(.((((....((.(.(((.(......((.....((..(.((((...............)))).)..))...)).......).)))...((((.((((.(......))))).))))(..)..)))..)))).).).))..((((.((.((.....)).)).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(.(((.(.(...((.........))....)).....(...(........).).))).)...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))..........(..............)......))....))...(((((........)))))]]((((..(((((.....((((....))).....<.((((((...((((.((((((((((((((((((...{{..))))))....(((((....(((((.....(((.....))).....))))).....))))).....(((((((......))))))))))).).))))))).))))(...)....))))))....).......)).))).)))).)))..)).....((......)).)))).((((.....))))..))))..(.(......((((((..((..(....(.......(((((....(.{..).....)))))((.(((((((((((...)))))..)))))).))(...).......(((((((.(.].((.........))...(((((((....((((.....))))......))))))).}.(.(.(((..((((((.....((.....((((....)))).....))..))))..)))))(.(.(.........).).)........((..........(((((.......)))))..)..)....).)....)..))))))).)..)))..))))))...).)))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.(((((...(((((.((((((((..((((..(((...)))..))))....((((.....((((..((((........))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((...(((....{..)))...))).(((....))).))]]].].....((((((..((((.]].]]]))))))))))....)}.....)))..)))))).......(....(.((((((...((.......))...))))))...)....)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).)......((((((....))).)))...>.))..))).)))))....((((((((..((((.(.(((.(......(....).....).))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(((.((..)..).)))..)))))...)))....)))).)))))).))))).. Hypomethylated yeast 80S bound with cycloheximide, P-site tRNA, and A-site tRNA, messenger RNA, PRE; 25S rRNA 8t2y A3 121 2.2 RF00001 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Hypomethylated yeast 80S bound with cycloheximide, P-site tRNA, and A-site tRNA, messenger RNA, PRE; 5s rRNA 8t2y A4 158 2.2 RF00002 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Hypomethylated yeast 80S bound with cycloheximide, P-site tRNA, and A-site tRNA, messenger RNA, PRE; 5.8 S rRNA 8t2y tP 75 2.2 RF00005 URS00021ED942_559292 0030533 0006412 4932 agcgccgugacgcaguggaagcgcgcagggcucauaacccugauguccucggaucgaaaccgagcggcgcuacca <<<<<<<...<<<.......>>>.<<<<<<.......>>>>>.>...<<<<<.......>>>>>>>>>>>>.... (((((((...(((....[..)))..(((((.......))))).....(((((..]....)))))))))))).... Hypomethylated yeast 80S bound with cycloheximide, P-site tRNA, and A-site tRNA, messenger RNA, PRE; P site tRNA 8t2y tA 76 2.2 RF00005 0030533 4932 agcgccgugacgcaguaggaagcgcgcagggcucauaacccugauguccucggaucgaaaccgagcggcgcuacca <<<<<<<...<<<........>>>..<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((...(((.[...{..)))..(((((.......)))))....](((((..}....)))))))))))).... Hypomethylated yeast 80S bound with cycloheximide, P-site tRNA, and A-site tRNA, messenger RNA, PRE; A site tRNA 8t2y MR 12 2.2 4932 aaaaaugauuaa ............ ............ Hypomethylated yeast 80S bound with cycloheximide, P-site tRNA, and A-site tRNA, messenger RNA, PRE; messenger RNA 8t2z B5 1757 2.4 RF01960,RF02542,RF01959,RF00177 0003735 0005840 4932 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcgcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacncaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggcnguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgagnaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuucnguaggugnnccugcggaaggaucauu ...<<<<<.{.((((>>>>><<<<.<<<<<<...<.<...<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<..<<..<<....<<<..................<.....<<.<<.......>>.>>......>.........<<<<<............>>>>><...<<<<<<.....(((....................<<......>>>>>>>>.....>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>..>>>..>....>.>.....<<.....<..............>......>>......<<<.<...........>>.>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>>>>>.........<<<[[.....<.<<...<<<.<<....<<<<<<....<..............>....>>>>>>......<<<<......>>>>.....<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........<<<...................)))..........>>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..]]>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..)))).}<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<<..>>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>......<....<<<<<<..........>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<...<....<<........>>....>...>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>........ ...((((..[.[[[..))))((((.((((((...(.(....(.....(((.(((..((....((....((..........))...))[))......(((.......(((...(..((....((...................((....((.(((.....))).)).....)).........(((((............)))))(.(.((..((..........{...(.(....).).....(......).))..)).)...).(.((((.(((((..).)))))))))....))...)))...))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(..(....)..)...)))))).).....(.(((...((((.]...))).)))))......).).....(.(..(.....(......).....)....))....(.(.(.(...........))..)......)..((((([[....(.((((.....((..]])).......))))))))))..))))))))))..[......((([[...(.(.((...(.(.(.....((((((.(..(..............)..).))))))......(.((......)).).....(((((.((........(..((.......)).(((.....)))....).......)).))..))).........(((....(..(..........}......)..)...)))......)...(((..((.((...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)).))...))..)).)...)).)....(((.((....(...((((.........))))...).)).)))......{...(((.((.(((..((((((((.(((........)))))))))))..)))...((..]]))...))...].))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((.......(........)...........((((..(....(((((........((.(((........))).))......)))))...((.(((...(.((((((.(..((..((((......))..(.((......)))...))..))....((((..((..(((...(((((.((((((....))))))...)))))...))).))..(.((((((.....))))))....)...)))).)..))).))).....).))))).....)..))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.((...(.((..(...((((....(.(..((.(....).))..).)....))))...)..)).)...)).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}....... Hypomethylated yeast 80S bound with cycloheximide, P-site tRNA, and A-site tRNA, messenger RNA, POST; 18S rRNA 8t2z A1 3161 2.4 RF02540,RF02541,RF02543 0003735 0005840 4932 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........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..<<<..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<.<<<<<.<..<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>.>......>>>>>>>>>>>........<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<.........................<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<........>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<...<<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>>.<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<....<<.<<<<<<<.....<<<....<<<....<<<<.<............>>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>..>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<......<..........<<<.<<<<<<<<<<.......<<<<<........<.........>................<........>...>>>>>...>>>>>>>>>>>>>..........))).>....>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>.........<<..............>>.....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<......<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..[[[..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>............>>.>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<....<....>.....>>>>><<.<<<<<<<<<<<...>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<..<<<.................>>>...<<<<<.....<<<<..<<<..........>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))......<<<<<<<..<<<<.))))))>>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>..>>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<<...<<<<<<<<<<]]].>>>>>..>>>>>..>>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<.<..<<<<<......>>>>>..>>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((.(.(((((.(...((.((((((((...({((((......)))))[[(...).(((....}]])))....))))))))...))...).....)))))).))))...)....(((((((........))))))).....(((((..[[[..[)))))..)))..................................((....))............(..((((....))))............).....................(((((.(((((.........................(((((((((((((((((((((((.......(((((((......((((........)))).......))))))).....))))).))))))))))........(((....)))....)))))))).....))))).))))).[((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))).((((((......(((....)))..(((.((((((....((.(.(((.(......((.....((..(.((((...............)))).)..))...)).......).)))...((((.((((.(......))))).))))......)))..)))))).).))..((((.((.((.....)).)).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(.(((.(.(...((.........))....)).....(...(........).).))).)...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....))).........((..............)).....))....))...(((((........)))))]]((((..(((((.....((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))....(((((....(((((.....(((.....))).....))))).....))))).....(((((((......))))))))))).).))))))).))))(...)....))))))...)).......)).))).)))).)))..)).....((......)).)))).((((.....))))..))))..(.(......((((((..((..(....(.......(((((....(.{..).....)))))((.(((((((((((...)))))..)))))).))(...).......(((((((.(.].((.........))...(((((((....((((.....))))......))))))).}.(.(.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(.(.(.........).).)........((..........(((((.......)))))..)..)....).)....)..))))))).)..)))..))))))...).)))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.(((((...(((((.((((((((..(((.................)))....((((.....((((..((.(........).))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((...(((....{..)))...))).(((....))).))]]].].....((((((..((((.]..]]]))))))))))....)}.....)))..)))))).......(....(.((((((...((.......))...))))))...)....)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).)......((((((....))).)))...>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......(((((..(((.((....((.(........(((((((..).)))))).....))).......(..(((...(((((.(..(((......)))..).))))).)))..).............)).)))..)))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Hypomethylated yeast 80S bound with cycloheximide, P-site tRNA, and A-site tRNA, messenger RNA, POST; 25S rRNA 8t2z A3 121 2.4 RF00001 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<<............>>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((.....(((((((.....((((((...(....)...))).)..))....)))))).).((((((.......(((((..((....)).))))).....))))))))))))))). Hypomethylated yeast 80S bound with cycloheximide, P-site tRNA, and A-site tRNA, messenger RNA, POST; 5s rRNA 8t2z A4 158 2.4 RF00002 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Hypomethylated yeast 80S bound with cycloheximide, P-site tRNA, and A-site tRNA, messenger RNA, POST; 5.8 S rRNA 8t2z tP 75 2.4 RF00005 URS00021ED942_559292 0030533 0006412 4932 agcgccgugacgcaguggaagcgcgcagggcucauaacccugauguccucggaucgaaaccgagcggcgcuacca <<<<<<<...<<<.......>>>.<<<<<<.......>>>>>.>...<<<<<.......>>>>>>>>>>>>.... (((((((...(((.......)))..(((((.......))))).....((((.........))))))))))).... Hypomethylated yeast 80S bound with cycloheximide, P-site tRNA, and A-site tRNA, messenger RNA, POST; P site tRNA 8t2z tA 76 2.4 RF00005 0030533 4932 agcgccgugacgcaguaggaagcgcgcagggcucauaacccugauguccucggaucgaaaccgagcggcgcuacca <<<<<<<...<<<........>>>..<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((...((..[...{...))..(((.(.......).)))....](((((..}....)))))))))))).... Hypomethylated yeast 80S bound with cycloheximide, P-site tRNA, and A-site tRNA, messenger RNA, POST; A site tRNA 8t2z MR 12 2.4 4932 aaaaaugaugaa ............ ............ Hypomethylated yeast 80S bound with cycloheximide, P-site tRNA, and A-site tRNA, messenger RNA, POST; messenger RNA 8t30 B5 1782 2.88 RF01960,RF02542,RF01959,RF00177 0003735 0005840 4932 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugaguccuuguggcucuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacncaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggcnguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgagnaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuucnguaggugnnccugcggaaggaucauu ...<<<<<.[.((((>>>>><<<<.<<<<<<...<.<...<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<..<<..<<....<<<..................<.....<<.<<<.....>>>.>>......>.........<<<<<............>>>>><...<<<<<<......................................>>>>>>.....>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<<<<<<....>>>>...>>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>..>>>..>....>.>.....<<...........................>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>>.........<<<((.....<.<<...<<<.<<....<<<<<<.<<.<..............>.>>.>>>>>>.....<<<.<.........<...........>.........>.>>>....<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........<<<....<<...................>..>...>>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..))>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<..<<..<<<...<<<<<.<.<<<<<..>>>>>.>...>>>>>...>>>.>>....<<<<<<.....>>>>>>........>>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<.<..<...<<<......>>>...>..>.>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>........ ...((((..[.[[[..))))((((.((((((...(.(....(.....(((.(((..((....((....((..........))...)){))......(((.......(((...(..((....(((..................((....((..((.....))..)).....)).........(((((............)))))(.(.(((.((......[.[.[.[.(.(....).).....(......).)).))).)...).(.((((...(((..).))..)))))...)))...)))...))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(..(....)..)...)))))).).....(.(((...((((.}...))).)))))......).).....((...(.....(......).....)....))....(.(.(.(...........))..)......)..((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(.(.(.....((((((.((.(..............).)).))))))......((((.............(.....)...........)))).....(((((.((........(..((.......))..((.....)).....).......)).))..)))................(..(.......]..]].]...)..)............)...(((.(((.((...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)).)))..))..)).)...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((.......(........)...........((((..(....(((((........((.(((........))).))......)))))...((.(((...(.((((((....((..((((......))..(.((......)))...))..))....((((..((..((....(((((..(.((((..)))).)....)))))....)).))..(.((((((.....))))))....)...))))....))).))).....).))))).....)..))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.((...(.((..(...((((..(.(.((.((.(....).)).)).)..).))))...)..)).)...)).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>....... Hypomethylated yeast 80S bound with cycloheximide, unmodified U2921, mid rotated; 18S rRNA 8t30 A1 3159 2.88 RF02540,RF02541,RF02543 0003735 0005840 4932 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........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..<<<...<.......<<.<<<<<<...>>>>>>.>>.......>.....<<<<<<.<<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<.........................<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<..........>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<....<<.<<<<<<<.....<<<....<<<..<.<<<<...............>>>>.>..>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>..>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>......................>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>>..<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<..........>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<<<<<<<<<<<<..[[[..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>.>.>>>>>>>.>>>>.........>>>>>>..........>.>>.>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<.<<<<<<<<<<<...>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<..<<<.....<<<<....>>>>.....>>>>>>>>..>>>>><<<.<..........>.>>>.......<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<..<<<<<<.<.....>.>>>>>>...<<<<<.....<<<<..<<<<........>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))......<<<<<<<..<<<<.))))))>>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>..>>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<....<<<<<<<<<<]]].>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<....<<<......>>>....>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((..(((.((((((((...({((((......)))))[[(...).(((....}]])))....))))))))...)))..))....)))))))))))...)....(((((((........))))))).....(((((..[[[.[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.(((((.........................(((((((((((((((((((((((.......(((((((......(((..........))).......))))))).....))))).))))))))))........(((....)))....)))))))).....))))).))))).[((((........))))((((((....((((((.((((((..(((..((((.......))))..)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((......(((....)))..(((.(.((((....((.(.(((.(......((.....((..(.((((...............)))).)..))...)).......).)))...((((.((((.(......))))).))))......)))..)))).).).))..((((.((.((.....)).)).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(.(.(.(.(...((.........))....)).........(........)...).).)...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........(.((............))).....))....))...(((((........)))))]]((((..(((((.....((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))....(((((....(((((.....(((.....))).....))))).....))))).....(((((((......))))))))))).).))))))).))))(...)....))))))...)).......)).))).)))).)))..)).....((......)).)))).((((.....))))..))))..(.(......((((((..((..(....(.......(((((....(.{..).....)))))((.(((((((((((...)))))..)))))).))(...).......(((((((.(.].((.........))...(((((((....((((.....))))......))))))).}.(.(.(((..((((((.(...((.....((((....)))).....)).)))))..))))).(................)........((..........(((((.......)))))..)..)....).)....)..))))))).)..)))..))))))...).)))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.(((((...(((((.((((((((..((((..(.(....))..))))....((((.....((((..((((........))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((...(((....{..)))...))).(((....))).))]]].].....((((((..((((.]].]]]))))))))))....)}.....)))..)))))).......(....(.((((((...((.......))...))))))...)....)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).)......((((((....))).)))...>.))..))).)))))....((((((((..((((.(.(((.(......(....).....).))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(((.((..)..).)))..)))))...)))....)))).)))))).))))).. Hypomethylated yeast 80S bound with cycloheximide, unmodified U2921, mid rotated; 25S rRNA 8t30 A3 121 2.88 RF00001 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Hypomethylated yeast 80S bound with cycloheximide, unmodified U2921, mid rotated; 5s rRNA 8t30 A4 158 2.88 RF00002 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Hypomethylated yeast 80S bound with cycloheximide, unmodified U2921, mid rotated; 5.8 S rRNA 8t3a B5 1757 2.86 RF01960,RF02542,RF01959,RF00177 0003735 0005840 4932 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...<<<<<.[.((((>>>>><<<<.<<<<<<...<.<..........<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<..<<..<<....<<<..................<<....<<.<<.......>>.>>.....>>.........<<<<<............>>>>><...<<<<<<.......[..............................>>>>>>.....>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>..>>>.......>.>.....<<<..<..................>...>>>......<<..<...........>..>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>>>>>.........<<<((.....<.<<...<<<.<<....<<<<<<.<..<..............>..>.>>>>>>......<<<<......>>>>.....<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........<<<...................]............>>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..))>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<......>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>......<....<<<<<<..........>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<.........<<........>>.........>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>........ ...((((..[.[[[..))))((((.((((((...(.(....(.....(((.(((..((....((.....(..........)....))[))......(((.......(((...(..((....((...................((....((.((.......)).)).....)).........(((((............)))))(.(.((..........{{..{...(.(....).).....(......).....)).)...).(.((((..((((..).))).)))))....))...)))...))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(..(....)..)...)))))).).....(.(((...((((.]...))).)))))......).).....((...(.(...(......)...).)....))....(.(.(.(...........))..)......)..((((([[....(.((((.....((..]])).......))))))))))..))))))))))..[......((([[...(.(.((...(.(.(.....((((((.(..(..............)..).))))))......(.((......)).).....((((..((........(..((.......)).(((.....)))....).......))..)..)))...........(....(.............}}.}......)...)........)...(((.(((.((...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)).)))..))..)).)...)).)....(((.((....(...((((.........))))...).)).)))......{...(((.((.(((..((((((((.(((........)))))))))))..)))...((..]]))...))...].))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((.......(........)...........((((..(....(.(((........((.(((........))).))......))).)....(.(((...(.((((((....((..((((......))..(.((......)))...))..))....((((..((..(((...(((((.((((((....))))))...)))))...))).))..(.((((((.....))))))....)...))))....))).))).....).))))......)..))))...)).)))).))).(...(((((((......((.....((..(.((....)).)..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.(((((((..((...(.((..(...((((....(.(..((.(....).))..).)....))))...)..)).)...))..))))))))..)).))))...).))...)..)..(((((((((....)))))))))}....... Hypomethylated yeast 80S bound with Taura syndrome virus (TSV) internal ribosome entry site (IRES), eEF2, GDP, sordarin, and hibernating factor Los2; 18S rRNA 8t3a A1 3214 2.86 RF02540,RF02541,RF02543 0003735 0005840 4932 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........................<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..<<<...<.......<<.<<<<<<...>>>>>>.>>.......>.....<<<<<<.<<<<<<<...<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>..>>.....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<.........................<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<......>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<..<<<<<.....>>>>>..>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<....<<.<<<<<<<.....<<<....<<<....<<<<...............>>>>....>>>..>>.>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>..>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<................................................>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>>..<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>................................>>....>>...<<<<<........>>>>>))<<<<.<<<<<<......<<<....>>>...<...<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..[[[..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>...>........>>.>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<....<....>.....>>>>><<.<<<<<<<<<<<...>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<.<<<.......>>>.>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<..<<<<<<.<........<<............<<....................>>....>>........>.>>>>>>...<<<<<.....<<<<..<<<..........>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))......<<<<<<<..<<<<.))))))>>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<....<<<<<<<<<<]]].>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((.(((...))).)).))....)........((((.(.(((((.(...((.((((.(((...({((((......)))))[[(...).(((....}]])))....))).))).)..))...).....)))))).))))...)....(((((((........))))))).....(((((..[[[[.[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((........................(((((((((((((((((((((((.......(((((((......((((........)))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))).((((((......(((....)))..(((.((((((....((.(.(((.(......((.....((..(.(((.................))).)..))...)).......).)))...((((.((((.(......))))).))))......)))..)))))).).))..((((.((.((.....)).)).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{..((((...(....................)......(..............).))))....)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...((((((...((.....)).))))))....[[(((.((...((....(((....)))........(.(..............)).....))....))...(((((........)))))]]((((..(((((.....((((....)))...(.<.((((((...((((.((((((((((((((.(((...{{..))).))....(((((....(((((.....(((.....))).....))))).....))))).....(((((((......))))))))))).).))))))).))))(...)....))))))...)).......)).))).)))).)))..)).....((......)).)))).((((.....))))..))))..(.(......((((((..((..(....(.......(((((....(.{..).....)))))((.(((((((((((...)))))..)))))).))(...).......(((((((.(.].((.........))...(((((((....((((.....))))......))))))).}.(.(.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(.................)........((..........(((((.......)))))..)..)....).)....)..))))))).)..)))..))))))...).)))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.(((((...(((((.((((((((..(((..(..........(.............((....(...)...........)).....)..........)..)))....((((.....((((..((.(........).))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((...(((....{..)))...))).(((....))).))]]].].....((((((..((((.].]]]]))))))))))....)}.....)))..)))))).......(....(.((((((...((.......))...))))))...)....)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).)......((((((....))).)))...>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......(.((((.(((.((....((.(........(((((((..).)))))).....))).......((.(((...(((.(.(..(((......)))..).).))).))).)).............)).))).)))).)..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(((.((..)..).)))..)))))...)))....)))).)))))).))))).. Hypomethylated yeast 80S bound with Taura syndrome virus (TSV) internal ribosome entry site (IRES), eEF2, GDP, sordarin, and hibernating factor Los2; 25S rRNA 8t3a A3 121 2.86 RF00001 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<<............>>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((.....(((((((.....((((((...(....)...))).)..))....)))))).).((((((.......(((((..((....)).))))).....))))))))))))))). Hypomethylated yeast 80S bound with Taura syndrome virus (TSV) internal ribosome entry site (IRES), eEF2, GDP, sordarin, and hibernating factor Los2; 5s rRNA 8t3a A4 158 2.86 RF00002 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Hypomethylated yeast 80S bound with Taura syndrome virus (TSV) internal ribosome entry site (IRES), eEF2, GDP, sordarin, and hibernating factor Los2; 5.8 S rRNA 8t3a tE 77 2.86 RF00005 0030533 4932 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(.(((..]....))).)))))))..... Hypomethylated yeast 80S bound with Taura syndrome virus (TSV) internal ribosome entry site (IRES), eEF2, GDP, sordarin, and hibernating factor Los2; E site tRNA 8t3b B5 1757 3.08 RF01960,RF02542,RF01959,RF00177 0003735 0005840 4932 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...<<<<<.{.((((>>>>><<<<.<<<<<<...<.<...<......<<<.<<<..<<....<.....<<..........>>....>.>>......<<........<<<..<<..<<....<<<..................<<....<<.<<<.....>>>.>>.....>>.........<<<<<............>>>>>...<<....<......((..............................>...>>.........<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<<..>>>.>...>>>>>>.........<<<....<<<.....>>>..>>>..>....>.>.....<<<....<..............>.....>>>......<<..<...........>..>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>>>>>.........<<<[[.....<.<<...<<<.<<....<<<<<<........................>>>>>>.......<<<......>>>......<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>...............................))...................>>....<<<<<<.<<...<<<<..<<<.<<<<<<.<...<<<......>>>......>.>>>>>>.>>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..]]>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..)))).}<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<........<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<..<<..<<<<..<<<<<.<.<<<<....>>>>.>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>........>>>>....>>>.>>>.....>>>>>>>.....>.>>>>>......>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>......<....<<<<<<..........>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<..........<<........>>..........>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>........ ...((((..[.[[[..))))((((.((((((...(.(....(.....(((.(((..((....((....((..........))...)).))......(((.......(((...(..((....((...................((....((.(((.....))).)).....)).........(((((............)))))..(((....(......{{..{...(........).....(......).)...)).).....(.((((.(((((..).)))))))))....))...)))...))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(..(....)..)...)))))).).....(.(((...((((.....))).)))))......).).....(((........(......).........)))....(.(((.(...........)).))......)..((((([[....(.((((.....((..]])).......))))))))))..))))))))))..[......((([[...(.(.((...(.(.(.....((((((....(..............)....))))))......(.((......)).).....(((((.((........(..((.......)).(((.....)))....).......)).))..)))...........(....(..(..........}}}....)..)...)........)...(((..((.((...((((..((..((((((.....((........))........))))))..)).......((....))...))))..).)))...))..)).)...)).)....(((.((....(...((((.........))))...).)).)))......{...(((.((.(((..((((((((.((..........))))))))))..)))...((..]]))...))...].))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((.(...((.((((.(.......(........)............(((...(...(((((........((.(((........))).))......)))))...((.(((...(.((((((....((..((.(......)...(.((......)))...))..))....(((...((..(((...(((((.((((((....))))))...)))))...))).))..(.(((((.......)))))....)....)))....))).))).....).))))).....)..)).)...)..)))).))......(((((((......((.....((..((((....))))..))....)).......)))))))...........(((((............)))))..........).))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.((...(.((..(...((((....(.(..((.(....).))..).)....))))...)..)).)...)).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}....... Hypomethylated yeast 80S bound with Taura syndrome virus (TSV) internal ribosome entry site (IRES), eEF2, GDP, and sordarin, Structure I; 18S rRNA 8t3b A1 3216 3.08 RF02540,RF02541,RF02543 0003735 0005840 4932 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........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..<<<...........<<.<<<<<<...>>>>>>.>>.............<<<<<<<.<<<<.<...<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>>..>>..>......>>>>>>>>>>>........<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<<........................<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<......>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<....<<.<<<<<<<.....<<<....<<<....<<<.................>>>....>>>..>>.>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>..>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<........<<<<........<.........>.............................>>>>....>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>>..<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>................................>>....>>...<<<<<........>>>>>))<<<<.<<<<<<......<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..[[[..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>............>>.>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<.<<<<<<<<<<<...>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<..<<<.....<<<<....>>>>.....>>>>>>>>..>>>>>.<<<<<.......>>>>>.........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<..<<<<<<<<<<<<<<..<<..........<<<........................>>>..>>>.>>>.>>>>>>>>>>...<<<<<.....<<<<..<<<..........>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))......<<<<<<<..<<<<.))))))>>>>>>>>>>>.........>>>>..>>>>>>.......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<...<<<<<<<<<<<]]].>>>>>..>>>>>>..>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((.(.(.(((((.(...((.((((((((...({((((......)))))[[(...).(((....}]])))....))))))))...))...).....)))))).).))...)....(((((((........))))))).....(((((..[[[[.[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((........................(((((((((((((((((((((((.......(((((((.......(((........)))........))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((......(((....)))..(((.((((((....((.(.(((.(......((.....((..(.(((.................))).)..))...)).......).)))...((((.((((.(......))))).))))......)))..)))))).).))..((((.((.((.....)).)).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{...(((.(.(...((.........))....)).....(...(........).).))).....)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...((((((...((.....)).))))))....[[(((.((...((....(((....))).........((..............)).....))....))...(((((........)))))]]((((..(((((.....((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))....(((((....(((((......((.....))......))))).....))))).....(((((((......))))))))))).).))))))).))))(...)....))))))...)).......)).))).)))).)))..)).....((......)).)))).((((.....))))..))))..(.(......((((((..((..(....(.......(((((....(.{..).....)))))((.(((((((((((...)))))..)))))).))(...).......(((((((.(.].((.........))...(((((((....((((.....))))......))))))).}.(.(.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(.(.(.........).).)........((..........(((((.......)))))..)..)....).)....)..))))))).)..)))..))))))...).)))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.(((((...(((((.((((((((..(((((((((((.(...((..........(..(..(......)............)..)..))..).).))))))))))....((((.....((((..((.(........).))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((...(((....{..)))...))).(((....))).))]]].].....((((((..((((.].]]]]))))))))))....)}.....)))..)))))).......(....(.((((((...((.......))...))))))...)....)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).)......((((((....))).)))...>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((....((.(.(..(((......)))..).).))..)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(((.((..)..).)))..)))))...)))....)))).)))))).))))).. Hypomethylated yeast 80S bound with Taura syndrome virus (TSV) internal ribosome entry site (IRES), eEF2, GDP, and sordarin, Structure I; 25S rRNA 8t3b A3 121 3.08 RF00001 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. ((((((.((.....(((((((......(((((...(....)...))).)..).....)))))).).((((((.......(((((..((....)).))))).....)))))))).)))))). Hypomethylated yeast 80S bound with Taura syndrome virus (TSV) internal ribosome entry site (IRES), eEF2, GDP, and sordarin, Structure I; 5s rRNA 8t3b A4 158 3.08 RF00002 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<<<<....>>>>.....<.<<<......>>..............>>>..>...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Hypomethylated yeast 80S bound with Taura syndrome virus (TSV) internal ribosome entry site (IRES), eEF2, GDP, and sordarin, Structure I; 5.8 S rRNA 8t3b EC 200 3.08 URS000268147B_142102 142102 aaacuccauguauugguuacccaucugcaucgaaaacucuccgaacacuaggugcaguaaggcuuucauggagugguuugcuauuuagcguacguguaccauaggcagccccaaaaacacgugugaggagaaagucccagucacuuugggcaaaguagacagccgcgcuugcguggugggacuuaauuaaugccugcuaa ...<<<<<<................<<..........((((.............>>...........>>>>>>.<<...<<<....>>>.........>>...<......>................)))).....<<.<<<<<<<.((((.>>>>.>>>..<<<<<....>>>>>..>>...........))))..... ...((((((...............(((..............[............)))..........)))))).(....((......)).....[....)...((.....))......]........]........((.((((((..[[[[..))).)))..((.((....)).))..))...........]]]]..... Hypomethylated yeast 80S bound with Taura syndrome virus (TSV) internal ribosome entry site (IRES), eEF2, GDP, and sordarin, Structure I; TSV IRES 8t3c B5 1757 3.86 RF01960,RF02542,RF01959,RF00177 0003735 0005840 4932 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...<<<<<.[.((((>>>>><<<<.<<<<<<...<.<..........<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<..<<..<<....<<<..................<<....<<..<<.....>>..>>.....>>.........<<<<<............>>>>>....<<<<<<.....[................................>>>>>>.........<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>..>>>.......>.>.....<<<..<.<..............>.>...>>>......<<<.<...........>>.>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>>>>>.........<<<((.....<.<<...<<<.<<....<<<<<<........................>>>>>>.......<<<......>>>......<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........<<<....................]...........>>>.....>>....<<<<<<.<<...<<<<..<<<.<<<<<<.....<<<......>>>........>>>>>>.>>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..))>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<........<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>.<.<<.<<<..<<<<<<<<<....<<<.<<<<......>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<...<<<<....<<<....>>>......>>>>...>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>...>.>>>>>>>>....>.>>>>>......>>>>.>>>.....<<<<<<<.......<.....<<..<<<<....>>>>..>>....>........>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<.........<<........>>.........>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>........ ...((((..[.[[[..))))((((.((((((...(.(....(.....(((.(((..((....((.....(..........)....))[))......(((.......(((...(..((....((...................((....((..((.....))..)).....)).........(((((............)))))(.(.((..((.......{..{...(.(....).).....(......).))..)).)...).(.((((...(((..).))..)))))....))...)))...))).(((....((.....((((((((.......)))))))).))......)))...(((.((((....))))....)))))).((.(((..........))).)).(..(....)..)...)))))).).....(.(((...((((.]...))).)))))......).).....(.(..(.....(......).....)....))....(.(.(.(...........))..)......)..((((([[....(.((((.....((..]])).......))))))))))..))))))))))..[......((([[...(.(.((.....(.(.....((((((.(..(..............)..).)))))).......(((......)))......(((((.((........(..(.........)..((.....)).....).......)).))..))).........(((....(.............}}........)...)))......)...(((..((..(...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)..))...))..)).....)).)....(((.((....(...((.(.........).))...).)).)))......{....((.((.(((..((((((((.((..........))))))))))..)))...((..]]))...))...].)).)))).(((......((.(....).))....)))...]]].]((((..(((((((..((.((((((..(((..(((((.......(........)...........((((..(....(((((........((.(((........))).))......)))))....(.(((...(.((((((....((..(((........)..(.((......)))...))..))....(((...((...((...(.(((..(.(((....)))).....))).)...))..))..(.(((((.......)))))....)....)))....))).))).....).))))......)..))))...)).)))..))).(...(((((((......(......((..(.((....)).)..)).....).......)))))))......(....((((.(..........).))))....)..)..))))))....(.((((((.......)))))).)......))...))))))).)).))..(.(..((.(..((((.((..(..(((((((.((...(.((..(...((.(....(.(..((.(....).))..).)....).))...)..)).)...)).))))))).)..)).))))...).))...)..)..(((((((((....)))))))))}....... Hypomethylated yeast 80S bound with Taura syndrome virus (TSV) internal ribosome entry site (IRES), eEF2, GDP, and sordarin, Structure II; 18S rRNA 8t3c A1 3216 3.86 RF02540,RF02541,RF02543 0003735 0005840 4932 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........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..<<<...........<<.<<<<<<...>>>>>>.>>.............<<<<<<<.<<<<.<...<<.<<<<<<<<.....<<<<......>>>>.(.......<<<......)>>>....>>>>>>>>...>>..>......>>>>>>>>>>>........<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<<........................<<<<<<<.<<<<<<<<<<<<<<<......<<<<<<<<......<<<<<......>>>>>.......>>>>>>>>....>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<..<<<<<.....>>>>>..>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<....<....>....>>>.>>>.>>....>>>>>>.>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<....<<.<<<<<<<.....<<<....<<<....<<<.................>>>....>>>..>>.>.....>>>>>...<<<<.<<<<.........>>>>.>>>>.....>>>>..>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.........<<<........<.........>.............................>>>.....>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>................................>>....>>...<<<<<........>>>>>))<<<<..<<<<<......<<<....>>>...<...<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..[[[..>>>>>>....<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>.....<<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>...>........>>.>>>.>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<...............>>>>><<.<<<<<<<<<<<...>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>>.<<<<<.......>>>>>.........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<..<<<<<<<<<<.<<<..<<..........<............................>..>>.>>>..>>>>>>>>>>...<<<<<.....<<<<..<<............>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))......<<<<<<<..<<<<.))))))>>>>>>>>>>>.........>>>>..>>>>>>.......<<.<...<<<<<<...<<.......>>...>>>>>>....>..>>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<...<<<<<<<<<<<]]].>>>>>..>>>>>>..>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((.(((...))).)).))....)........((.(.(..((((.(...((.((((.(.(...({((((......)))))[[(...).(((....}]])))....).).))).)..))...).....)))).).).))...)....(((((((........)))))))......((((..[[[[.[))))...)))..................................((....))............(..((((....))))............).....................(((((.(((((.........................(((((((((((((((((((((((.......(((((((.......(((........)))........))))))).....))))).))))))))))........(((....)))....)))))))).....))))).))))).[((((........))))((((((....(((((..((((((..(((...((((.....))))...)))...(......).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....))))))..)))))..((.(...((((((.....(((((.((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))).))))).(.((.......))...)..))))))......).))..((((((......(((....)))..((.(((((((....((.(.(((.(......((.....((..(.(((.................))).)..))...)).......).)))...((((.((((.(......))))).))))......)))..)))))).).))..((((.((.((.....)).)).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.........((....(...((.........))....)......(...(........).)..)).....)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...((((((...((.....)).))))))....[[(((.((...((....(((....))).........((..............)).....))....))...(((((........)))))]]((((..(((.(.....((((....)))...(.<.((((((...(.((.((((((((((((((((((...{{..))))))....(((((....(((((......((.....))......))))).....)))))......((((((......)))))).)))).).))))))).)).)(...)....))))))...)).......)..))).)))).)))..)).....((......)).)))).((((.....))))..))))..(.(......((((((..((..(....(.......(((((....(.{..).....)))))((.(((((((.(((...))).)..)))))).))(...).......(((((((.(.].((.........))...(((((((....((((.....))))......))))))).}.(.(.(((..((((((.(...((.....((((....)))).....)).)))))..)))))..(.(.........).)...........(..........(((((.......)))))..).......).)....)..))))))).)..)))..))))))...).)))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.(((((...(((((.((((((((..(((((((.((..(...((..........(..(..(......)............)..)..))..)...)).)))))))....((((.....((((..((.(........).))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((...(((....{..)))...))).(((....))).))]]].]....(((((((..((((.].]]]])))))))))))...)}.....)))..)))))).......(....(.((((((...((.......))...))))))...)....)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).)......((((((....))).)))...>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.............))))...)))).))))....)))))))).......(.((((.(((.((....((.(........(.((.((..).).)).).....))).......((((((...(((.(.(..(((......)))..).).))).)))))).............)).))).)))).)..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(((.((..)..).)))..)))))...)))....)))).)))))).))))).. Hypomethylated yeast 80S bound with Taura syndrome virus (TSV) internal ribosome entry site (IRES), eEF2, GDP, and sordarin, Structure II; 25S rRNA 8t3c A3 121 3.86 RF00001 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (.(((((((.....(((((((......(((((...(....)...))).)..).....)))))).).((((((.......(((((..((....)).))))).....))))))))))))).). Hypomethylated yeast 80S bound with Taura syndrome virus (TSV) internal ribosome entry site (IRES), eEF2, GDP, and sordarin, Structure II; 5s rRNA 8t3c A4 158 3.86 RF00002 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((.(((....))).)))))..................... Hypomethylated yeast 80S bound with Taura syndrome virus (TSV) internal ribosome entry site (IRES), eEF2, GDP, and sordarin, Structure II; 5.8 S rRNA 8t3c EC 200 3.86 URS000268147B_142102 142102 aaacuccauguauugguuacccaucugcaucgaaaacucuccgaacacuaggugcaguaaggcuuucauggagugguuugcuauuuagcguacguguaccauaggcagccccaaaaacacgugugaggagaaagucccagucacuuugggcaaaguagacagccgcgcuugcguggugggacuuaauuaaugccugcuaa ...<<<<<<...............<<<<<........(((((..........>>>>>..........>>>>>><<....<<<....>>>..........>>..<<.....>>..............))))).....[[.((((((..<<<<..))).)))..<<<<<....>>>>>..]]...........>>>>..... ...((((((...............(((............[[[............)))..........)))))).[....((......)).....((...]....(.....)......)).......]].]......[..[[[.[...((((...]..]]]..((.((....)).))...]...........))))..... Hypomethylated yeast 80S bound with Taura syndrome virus (TSV) internal ribosome entry site (IRES), eEF2, GDP, and sordarin, Structure II; TSV IRES 8t3d B5 1757 2.95 RF01960,RF02542,RF01959,RF00177 0003735 0005840 4932 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...<<<<<.{.((((>>>>><<<<.<<<<<<...<.<..........<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<..<<..<<....<<<..................<.....<<.<<<.....>>>.>>......>.........<<<<<............>>>>><...<<<<<<.....(((..............................>>>>>>.....>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<<..>>>.>...>>>>>>.........<<<....<<<.....>>>..>>>.......>.>.....<<...<<<..............>>>....>>......<<<.<..<....>...>>.>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>>>>>.........<<<[[.....<.<<...<<<.<<....<<<<<<....<..............>....>>>>>>......<<<<......>>>>.....<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........<<<...................)))..........>>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.....<<<......>>>........>>>>>>..>>......<<<....>>>..>>>>..>.>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..]]>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..)))).}<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<.<<<<....>>>>.>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<.........<<........>>.........>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>........ 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Hypomethylated yeast 80S bound with Taura syndrome virus (TSV) internal ribosome entry site (IRES), eEF2, GDP, and sordarin, Structure III; 18S rRNA 8t3d A1 3216 2.95 RF02540,RF02541,RF02543 0003735 0005840 4932 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........................<<<<<<.....<......>......>>>>>.>...<.....<<....>>..<<<<<......<<.....>>.....>>>>>..<<<...........<<.<<<<<<...>>>>>>.>>.............<<<<<<.<<<<<.<...<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>>..>>..>......>>>>>>>>>>>........<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>....>.............................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<.........................<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<........>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<....<<.<<<<<<<.....<<<....<<<..<.<<<.................>>>.>..>>>..>>.>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>..>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<........<.........>................<........>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>>..<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>.........<................>.....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<......<<<....>>>...<...<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..[[[..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>...>........>>.>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<...............>>>>><<.<<<<<<<<<<<...>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>>.<<<...........>>>.........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<..<<<<<<<<<<<<<<..<<..........<<<........................>>>..>>.>>>>.>>>>>>>>>>...<<<<<.....<<<<..<<<<........>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))......<<<<<<<..<<<<.))))))>>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<<]]].>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((.(.(.(((((.(...((..(((((((...({((((......)))))[[(...).(((....}]])))....)))))))....))...).....)))))).).))...)....(((((((........))))))).....(((((..[[[[.[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((........................(((((((((((((((.(((((((.......(((((((......((((........)))).......))))))).....))))).)).)))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((..((((.......))))..)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((......(((....)))..(((.((((((....((.(.(((.(......((.....((..(.(((.................))).)..))...)).......).)))...((((.((((.(......))))).))))......)))..)))))).).))..((((.((.((.....)).)).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((.(.(...((.........))....)).....(...(........).).)))).)..)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...((((((...((.....)).))))))....[[(((.((...((....(((....))).........((..............)).....))....))...(((((........)))))]]((((..(((((.....((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))....(((((....(((((.....(((.....))).....))))).....))))).....(((((((......))))))))))).).))))))).))))(...)....))))))...)).......)).))).)))).)))..)).....((......)).)))).(((.......)))..))))..(.(......((((((..((..(....(.......(((((....(.{..).....)))))((.(((((((((((...)))))..)))))).))(...).......(((((((.(.].((.........))...(((((((....((((.....))))......))))))).}.(.(.(((..((((((.....((.....((((....)))).....))..))))..)))))....(.........)............((..........(((((.......)))))..)..)....).)....)..))))))).)..)))..))))))...).)))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.(((((...(((((.((((((((..(((((((.((.((...((..........(..(..(......)............)..)..))..))..)).)))))))....((((.....((((..((((........))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((...(((....{..)))...))).(((....))).))]]].].....((((((..((((.].]]]]))))))))))....)}.....)))..)))))).......(....(.((((((...((.......))...))))))...)....)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).)......((((((....))).)))...>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((.(((...(((.(.(..(((......)))..).).))).))).)).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(((.((..)..).)))..)))))...)))....)))).)))))).))))).. Hypomethylated yeast 80S bound with Taura syndrome virus (TSV) internal ribosome entry site (IRES), eEF2, GDP, and sordarin, Structure III; 25S rRNA 8t3d A3 121 2.95 RF00001 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((.....(((((((.....((((((...(....)...))).)..))....)))))).).((((((.......(((((..((....)).))))).....))))))))))))))). Hypomethylated yeast 80S bound with Taura syndrome virus (TSV) internal ribosome entry site (IRES), eEF2, GDP, and sordarin, Structure III; 5s rRNA 8t3d A4 158 2.95 RF00002 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Hypomethylated yeast 80S bound with Taura syndrome virus (TSV) internal ribosome entry site (IRES), eEF2, GDP, and sordarin, Structure III; 5.8 S rRNA 8t3e B5 1757 3.04 RF01960,RF02542,RF01959,RF00177 0003735 0005840 4932 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...<<<<<.{.((((>>>>><<<<.<<<<<<...<.<..........<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<..<<..<<....<<<..................<.....<<.<<<.....>>>.>>......>.........<<<<<............>>>>><...<<<<<<.....((...............................>>>>>>.....>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<<..>>>.>...>>>>>>.........<<<....<<<.....>>>..>>>.......>.>.....<<<..<<................>>...>>>......<<..<...........>..>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>>>>>.........<<<[[.....<.<<...<<<.<<....<<<<<<....<..............>....>>>>>>........<<......>>.......<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........<<......<..............)).....>.....>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..]]>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..)))).}<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<.<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<......>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<.<<<<....>>>>.>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>..>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<....<....<<........>>....>....>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>........ 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Hypomethylated yeast 80S bound with Taura syndrome virus (TSV) internal ribosome entry site (IRES), eEF2, GDP, and sordarin, Structure IV; 18S rRNA 8t3e A1 3216 3.04 RF02540,RF02541,RF02543 0003735 0005840 4932 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........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((.(((...))).)).))....)........((((.(.(((((.(...((.((((.(.(...({((((......)))))[[(...).(((....}]])))....).).))).)..))...).....)))))).))))...)....(((((((........))))))).....(((((..[[[[.[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((........................(((((((((((((((((.(((((.......(((((((.......(((........)))........))))))).....)))))..)))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((..(.((((((.((((((..(((..((((.......))))..)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))..).))))))))).(.((.......))...)..))))))......).))).((((((......(((....)))..(((.((((((....((.(.(((.(......((.....((..(.(((.................))).)..))...)).......).)))...((((.((((.(......))))).))))......)))..)))))).).))..((((.((.((.....)).)).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((.(.(...((.........))....)).....(...(........).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...((((((...((.....)).))))))....[[(((.((...((....(((....))).........((..............)).....))....))...(((((........)))))]]((((..(((((.....((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))....(((((....(((((.....(((.....))).....))))).....))))).....(((((((......))))))))))).).))))))).))))(...)....))))))...)).......)).))).)))).)))..)).....((......)).)))).((((.....))))..))))..(.(......((((((..((..(....(.......(((((....(.{..).....)))))((.(((((((.(((...))).)..)))))).))(...).......(((((((.(.].((.........))...(((((((....((((.....))))......))))))).}.(.(.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(.(.(.........).).)........((..........(((((.......)))))..)..)....).)....)..))))))).)..)))..))))))...).)))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.(((((...(((((.((((((((..(((((((.((..((..(...........(..(..(......)............)..)...).))...)).)))))))....((((.....((((..((............))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((...(((....{..)))...))).(((....))).))]]].].....((((((..((((.].]]]]))))))))))....)}.....)))..)))))).......(....(.((((((...((.......))...))))))...)....)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).)......((((((....))).)))...>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......((((((.(((.((....((.(........((((.((..).).)))).....))).......((((((...(((.(.(..(((......)))..).).))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Hypomethylated yeast 80S bound with Taura syndrome virus (TSV) internal ribosome entry site (IRES), eEF2, GDP, and sordarin, Structure IV; 25S rRNA 8t3e A3 121 3.04 RF00001 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((.....(((((((.....((((((...(....)...))).)..))....)))))).).((((((.......(((((..((....)).))))).....))))))))))))))). Hypomethylated yeast 80S bound with Taura syndrome virus (TSV) internal ribosome entry site (IRES), eEF2, GDP, and sordarin, Structure IV; 5s rRNA 8t3e A4 158 3.04 RF00002 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<<<<....>>>>.....<.<<<......>>..............>>>..>...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Hypomethylated yeast 80S bound with Taura syndrome virus (TSV) internal ribosome entry site (IRES), eEF2, GDP, and sordarin, Structure IV; 5.8 S rRNA 8t3e EC 131 3.04 142102 aaacuccauguauugguuacccaucugcaucgaaaacucuccgaacacuaggugcaguaaggcuuucauggagugguuugcuauuuagcguacguguaccauaggcagccccaaaaacacgugugaggaga ...<<<<<.<................<<<..........((...........>>>...........>.>>>>>.<<<..<<......>>........>>>...........................)).. ...(.((.(...............(.(............[[[............).)..........).)).).(((..((......)).....[..)))..................].......]]].. Hypomethylated yeast 80S bound with Taura syndrome virus (TSV) internal ribosome entry site (IRES), eEF2, GDP, and sordarin, Structure IV; TSV IRES 8t3f B5 1757 3.09 RF01960,RF02542,RF01959,RF00177 0003735 0005840 4932 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...<<<<<.[.((((>>>>><<<<.<<<<<<...<.<...<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<..<.....<<<..<<..<<....<<<..................<.....<<.<<.......>>.>>......>.........<<<<<............>>>>>....<<<<<<.....[................................>>>>>>.........<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>>>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>..>>>..>....>.>.....<<<..<.<..............>.>...>>>......<<..<...........>..>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>>>>>.........<<<((.....<.<<...<<<.<<....<<<<<<....<..............>....>>>>>>.......<<<......>>>......<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........<<.....................]............>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>..>.>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..))>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<......>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>......<....<<<<<<..........>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<........<<........>>........>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>........ 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Hypomethylated yeast 80S bound with Taura syndrome virus (TSV) internal ribosome entry site (IRES), eEF2, GDP, and sordarin, Structure V; 18S rRNA 8t3f A1 3216 3.09 RF02540,RF02541,RF02543 0003735 0005840 4932 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Hypomethylated yeast 80S bound with Taura syndrome virus (TSV) internal ribosome entry site (IRES), eEF2, GDP, and sordarin, Structure V; 25S rRNA 8t3f A3 121 3.09 RF00001 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((.....(((((((.....((((((...(....)...))).)..))....)))))).).((((((.......(((((..((....)).))))).....))))))))))))))). Hypomethylated yeast 80S bound with Taura syndrome virus (TSV) internal ribosome entry site (IRES), eEF2, GDP, and sordarin, Structure V; 5s rRNA 8t3f A4 158 3.09 RF00002 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<<<<....>>>>.....<.<<<......>>..............>>>..>...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Hypomethylated yeast 80S bound with Taura syndrome virus (TSV) internal ribosome entry site (IRES), eEF2, GDP, and sordarin, Structure V; 5.8 S rRNA 8t5d A 117 3.2 RF00001 38185325 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggc <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>> (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))) Cryo-EM studies of the interplay between uS2 ribosomal protein and leaderless mRNA during bacterial translation initiation; 5S RNA 8t5d B 2903 3.2 RF02541 38185325 0003735 0005840 562 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Cryo-EM studies of the interplay between uS2 ribosomal protein and leaderless mRNA during bacterial translation initiation; 23S RNA 8t5d v 1539 3.2 RF01959,RF00177,RF02542,RF01960 38185325 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<.<<<......>>>.>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<.....>.>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<..<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>.>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>.............>>>>>.>>.<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<........<.......>.......>>>>>>>.....<<<<<.....>>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((.(..........).)).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..(.....).)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((((.......)))))))).....)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.((((((..((((((((((......((((((.....))))))....))))))))..)).))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((..(((((((....))))))).............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((.......(.........)......)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....))))))))..)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((...((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))....))...)..)..(((((((((....)))))))))}........... Cryo-EM studies of the interplay between uS2 ribosomal protein and leaderless mRNA during bacterial translation initiation; 16s RNA 8t5d x 12 3.2 38185325 38018 augagcacaaaa ............ ............ Cryo-EM studies of the interplay between uS2 ribosomal protein and leaderless mRNA during bacterial translation initiation; lmRNA 8t5d 5 77 3.2 RF00005 38185325 0030533 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Cryo-EM studies of the interplay between uS2 ribosomal protein and leaderless mRNA during bacterial translation initiation; tRNA 8t5h A 117 3.3 RF00001 38185325 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggc <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>> (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((.(((((...))))).)).......))...))))))))) Cryo-EM studies of the interplay between uS2 ribosomal protein and leaderless mRNA during bacterial translation initiation; 5S 8t5h B 2903 3.3 RF02541 38185325 0003735 0005840 562 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Cryo-EM studies of the interplay between uS2 ribosomal protein and leaderless mRNA during bacterial translation initiation; 16S 8t5h x 12 3.3 38185325 38018 augagcacaaaa ............ ............ Cryo-EM studies of the interplay between uS2 ribosomal protein and leaderless mRNA during bacterial translation initiation; lmRNA 8t5h 5 77 3.3 RF00005 38185325 0030533 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(((((.......)))))))))))..... Cryo-EM studies of the interplay between uS2 ribosomal protein and leaderless mRNA during bacterial translation initiation; tRNA 8t5s C 30 2.9 38747717 32630 uuuuuuuuuuuuuuuuuuuuuuuuuuuuuu .............................. .............................. Cryo-EM structure of DRH-1 helicase and C-terminal domain bound to dsRNA; RNA (30-MER) 8t5s B 30 2.9 38747717 32630 aaaaaaaaaaaaaaaaaaaaaaaaaaaaaa .............................. .............................. Cryo-EM structure of DRH-1 helicase and C-terminal domain bound to dsRNA; RNA (30-MER) 8t7s B 98 3.01 RF02348 38688943 1314 gacgcauaaagaugagacgcguuuuagagcuagaaauagcaaguuaaaauaaggcuaguccguuaucaacuugaaaaaguggcaccgagucggugcuu ....................<<<<<<..<<<<....>>>>....>>>>>>..<<.....>>.......<<<<....>>>>.<<<<<<...>>>>>>.. ....................((((((..((((....))))....))))))..(((..).)).......((((....)))).((((((...)))))).. SpRYmer bound to NAC PAM DNA; gRNA 8t7s H 88 3.01 RF02348 URS0002616B75_32630 38688943 1314 gaugagacgcguuuuagagcuagaaauagcaaguuaaaauaaggcuaguccguuaucaacuugaaaaaguggcaccgagucggugcuu ..........<<<<<<..<<<<....>>>>....>>>>>>..<<.....>>.......<<<<....>>>>.<<<<<<...>>>>>>.. ..........((((((..(((.(...))))....))))))..(((..).)).......((((....)))).((((((...)))))).. SpRYmer bound to NAC PAM DNA; gRNA 8t8b 1A 2872 2.65 RF02541 URS00001698E8_300852 37433044 0003735 0005840 300852 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<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<.....................>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<......>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((....)))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...((((((((.....))))))))....{.(((((((((..(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).))))....(((((((((.[.....)))))))))....}.(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...((((((((.(.((((((......)))).)))..))))))))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((.((((((((((((.([........(((((..(((......((((((((...]))))))))...)))............)))))).)))))))))))).)))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..((((.))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, A-site aminoacyl-tRNA analog ACC-PMN, and P-site formyl-MAI-tripeptidyl-tRNA analog ACCA-IAMf at 2.65A resolution; 23S Ribosomal RNA 8t8b 1B 120 2.65 RF00001 URS000080DEE8_300852 37433044 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>. .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, A-site aminoacyl-tRNA analog ACC-PMN, and P-site formyl-MAI-tripeptidyl-tRNA analog ACCA-IAMf at 2.65A resolution; 5S Ribosomal RNA 8t8b 1a 1500 2.65 RF00177,RF01959,RF02542,RF01960 URS000080DFED_300852 37433044 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<..[.>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>.......]..<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<<......>>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(.((((((..)))))).).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((((((....))))))).(.((((....)))))..)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, A-site aminoacyl-tRNA analog ACC-PMN, and P-site formyl-MAI-tripeptidyl-tRNA analog ACCA-IAMf at 2.65A resolution; 16S Ribosomal RNA 8t8b 2A 2867 2.65 RF02541 URS00001698E8_300852 37433044 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu 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(((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((..))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((.(.((((((......)))).)))..)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......(((((.((...(.(.......).)....)).........((......))...)))))...)))))))))).))..........]]].)....))))))))))...)))))))(((((((..)))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((.((.((((((.(.........(((((..(((......(((((.((....)).)))))...)))............)))))).)))))).)).))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))((((.))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, A-site aminoacyl-tRNA analog ACC-PMN, and P-site formyl-MAI-tripeptidyl-tRNA analog ACCA-IAMf at 2.65A resolution; 23S Ribosomal RNA 8t8b 2B 120 2.65 RF00001 URS000080DEE8_300852 37433044 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>>> .((((((((((....((((((.(....(((((((...(.....)...))))..)))...).)))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, A-site aminoacyl-tRNA analog ACC-PMN, and P-site formyl-MAI-tripeptidyl-tRNA analog ACCA-IAMf at 2.65A resolution; 5S Ribosomal RNA 8t8b 2a 1504 2.65 RF00177,RF01959,RF02542,RF01960 URS000080DFED_300852 37433044 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<..[.>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>.......]..<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>.....<......>....>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((...(((((((....))))))).....((....)).....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, A-site aminoacyl-tRNA analog ACC-PMN, and P-site formyl-MAI-tripeptidyl-tRNA analog ACCA-IAMf at 2.65A resolution; 16S Ribosomal RNA 8t8c 1A 2872 2.6 RF02541 URS00001698E8_300852 37433044 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>....<<<<<.....<<....>>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<..<<<...<<<.......>>>...>>>.........<<......>>....>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<.......<<<<<<<<....>>>>>>>>....>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((..(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...((((((((.(.((((((......)))).)))..))))))))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((..))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((.((((((.([........(((((..(((......((((((((...]))))))))...)))............)))))).)))))).)))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..((((.))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, A-site aminoacyl-tRNA analog ACC-PMN, and P-site formyl-MFI-tripeptidyl-tRNA analog ACCA-IFMf at 2.60A resolution; 23S Ribosomal RNA 8t8c 1B 120 2.6 RF00001 URS000080DEE8_300852 37433044 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, A-site aminoacyl-tRNA analog ACC-PMN, and P-site formyl-MFI-tripeptidyl-tRNA analog ACCA-IFMf at 2.60A resolution; 5S Ribosomal RNA 8t8c 1a 1500 2.6 RF00177,RF01959,RF02542,RF01960 URS000080DFED_300852 37433044 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<.<......>.>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((..)))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((((((....)))))))...((((....))))...)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, A-site aminoacyl-tRNA analog ACC-PMN, and P-site formyl-MFI-tripeptidyl-tRNA analog ACCA-IFMf at 2.60A resolution; 16S Ribosomal RNA 8t8c 2A 2867 2.6 RF02541 URS00001698E8_300852 37433044 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu 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(((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((()))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((.(.((.(((......)))..)))..)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......(.(((.((...(((.......)))....))......................))).)...)))))))))).))..........]]].)....))))))))))...)))))))(((((((())))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((.((.((((((.(.........(((((..(((......(((((.((....)).)))))...)))............)))))).)))))).)).))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))((.(.).).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, A-site aminoacyl-tRNA analog ACC-PMN, and P-site formyl-MFI-tripeptidyl-tRNA analog ACCA-IFMf at 2.60A resolution; 23S Ribosomal RNA 8t8c 2B 120 2.6 RF00001 URS000080DEE8_300852 37433044 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> (((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).))))))))))) Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, A-site aminoacyl-tRNA analog ACC-PMN, and P-site formyl-MFI-tripeptidyl-tRNA analog ACCA-IFMf at 2.60A resolution; 5S Ribosomal RNA 8t8c 2a 1504 2.6 RF00177,RF01959,RF02542,RF01960 URS000080DFED_300852 37433044 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>.....<......>....>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((.(....).)))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((((((....))))))).....((....)).....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, A-site aminoacyl-tRNA analog ACC-PMN, and P-site formyl-MFI-tripeptidyl-tRNA analog ACCA-IFMf at 2.60A resolution; 16S Ribosomal RNA 8tdy A 16 1.66 38818863 32630 agagnagaucuucucu ................ ................ 16mer self-complementary duplex RNA with D:U pair sequence 1; RNA 8tdz A 16 1.64 38818863 32630 agagaagnucuucucu ................ ................ 16mer self-complementary duplex RNA with D:U pair sequence 2; RNA 8te0 A 16 1.42 38818863 32630 agagnagaucuccucu ................ ................ 16mer self-complementary duplex RNA with D:C pair sequence 1; RNA 8te2 A 16 1.63 38818863 32630 agagaagnccuucucu ................ ................ 16mer self-complementary duplex RNA with D:C pair sequence 2; RNA 8tpu S7 74 4.1 RF00005 URS000035398D_36329 0030533 0006412 36329 ggguaauuggcgcaguugguuagcgcgcgggucucauaaucccgaggucgugaguucgauccucacauuaccca .<<<.....<<...........>><.<..<......>..>.>....<..<.........>..>...>>>..... ((.(.....((..(......).))(................)....(...(.......)....)..).)..).. Subtomogram averaged consensus structure of the malarial 80S ribosome in Plasmodium falciparum-infected human erythrocytes; 60S ribosomal protein L24, putative 8tpu SA 1608 4.1 RF01960,RF02542,RF01959,RF00177 0003735 0005840 36329 aaccugguugaucuugccaguagucauaugcuugucucaaagauuaagccaugcaagugaaaguauauauauauauauguagaaacugcgaacggcucauuaaaacaguuauagucuacuugacauuuauaaggauaacuacggaaaagcuguagcuaauacuugcauuauccuuuuggauaaguauuuguuagaaggaauuauaacaaagaaguaacacguaaaguguguaucaaucgaguuucugaccuaucagcuuuugauguuaggguauuggccuaacauggcuaugacggguaacggggaauuagaguucgauuccggagagggagccugagaaauagcuaccacaucuaaggaaggcagcaggcgcguaaauuacccaauucuaaagaagagagguagugacaagaaauaacaaugcaagguuuguauuggaauggugggaauuuaaaaccuucccagaguaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaauuguugcaguuaaaacgcucguaguugaauuucaaagaaucauucuuuuuaaaauccgauuuuguuacuuugaguaaauuagaguguucaaagcaaacaguuaaagcauuguguuugaauacuauagcauggaauaacaaaauugaacaagcuaaaauuuuuuguucuuauuuuggcuuaguuacgauuaauaggaguagcuuggggacauucguauucagaugucagaggugaaauucuuagauuuucuggagacgaacaacugcgaaagcauuugucuaaaauacuuccauuaaucaagaacgaaaguuaagggagugaagacgaucagauaccgucguaaucuuaaccauaaacuaugccgacuagguguuggaugaagugcuuccuucaguaccuuaugagaaaucaaagucuuuggguucuggggcgaguauucgcgcaagcgagaaaguuaaaagaauugacggaagggcaccaccaggcguggagcuugcggcuuaauuugacucaacacggggaaacucacuaguuuaagacauuggauggugaugcauggccguuuuuaguucgugaaugauuugucugguuaauuccgauaacgaacgagaucuuaaccugcuaauuagcggcgaguacacuguacuugcugcuucuuagaggaacauugugugucuaacacaaggaaguuuaaggcaacaacaggucugugauguccuuagaugaacuaggcugcacgcgugcuacacugauauauauaacgaguaaaauaugcuugcauacuuuuccuccgccgaaaggcguagguaaucuuuaucaauauauaucgugauggggauagauuauugcaauuauuaaucuugaacgaggaaugccuaguaagcaugauucaucagauugugcugacuacgucccugcccuuuguacacaccgcccgucgcuccuaccgauugaaagauaugaugaauuguuuggacaagaaaaauuuuuucuggaaaaaccguaaauccuaucuuuuaaaggaaggagaagucguaacaagguuuccguaggugaaccugcggaaggaucau ...<<<<<.[.((((>>>>><<<<.<<<<<<...<<<...<......<<<.<<<..<<....<<...<<<<<<..>>>>>>...>>.>>......<<........<<<..<<..<<...<<<<........<<.....<<<<<<.....>>>>>>......>>....<<<<<<....>>>>>>...<<<<<<<.<......>.>>>>>>>.......<<<.....>>>....>>>>..>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>..>>>..>....>>>.....<<<<<<<<<.>>>>>>>>>......<<<<<<.........>>>>>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>>.........<<<((.....<.<<...<<<.<<....<<<<.<....>.>>>>..<<<<<.>>.>>><<<<<<.<<.......<<...<.......>..<<<.......<<...>>>>>....>>......>>.>>..>>>>.....<<<<<.<<...<<<.<..........>.>>>...>>.>>>.>>.>>....<<<<<<..<<..<<<<<..<<<.<<<<<<.<...<<<......>>>......>.>>>>>>.>>>......<<<....>>>..>>>>>.>>.>>>.>>>...>>>...>>.>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<<<<<<<<.<<<<..>>>>.>>>>>>>>>>...<<..))>>...>>.....>>>.>>>.<<<.....<<<<<....>>>>>...>>>..)))).]<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<<<....<<.>>...<<.<<<..<<.<<<<<<....<<<<<<<<<...>>>...<<<......>>>...>>>>>>....<<<<<.<<<.<<<...<<<<<<<<<<<<...>>>>>>>>>>>>...>>>>>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>.....>>>>>>>...>>.>>>>.>>>.....<<<<<<<......<<...<.<<<<<..>>>>>.>...<<<.<<<<....>>>>.>>>....>>........>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<<.<<....<<<<<<<<.<<<..<<.<<<<...<<.<<<<<.>>>.>>.>>...>>>>.>>..>>>.>>>>>>>>...>>.>>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>....... ...((((..[.[[[..))))((((.(((.((...(((...((.....(((.(((..((....(....((.(((..))).))....)[))......(((.......(((..((..((...((((....[...((.....((.(((.....))).))......))....((((((....))))))...(((((((.(......).))))))).....(](((.....))))...))))..))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)....))).....((((((((...))))))))....(.((((((.........))))))......)..((((([[....(.((((.....((..]])).......))))))))))..)).)))))))..[......((([[...(.(.((...(((.((....(((..(....)..)))..((........))((((((.((.......((..((.......)).(((.......((...)))))....))......)).))..)))).....(((((.(....(((.(....()....).)))....).))).)).))...(((((((..((..(((((..(((.((((((.....((........))........)))))).)))......(((....)))..))))).)).))).)))..))))...)).)....((((((...((...((((.........))))...))))))))......{...(((.((.((((.(((((.((((())))).))))).))))...((..]]))...))...].))))))).(((......((((....))))....)))...]]].]((((..(((((((..((.((((.(..(((..(((((.......(........)...........(((((((....((.))....(.(((...(.((((((....(((((((((...)))..(.((......)))...)))))).....((((.(((.((((..((..((((((((...))))))))..))..)))))))..(.((((((.....))))))....)..)))).....))).))).....).))))......)))))))...)).)))..))).(...((((((.......((...(.(((((..))))).)...((..((((....))))..))....)).........))))))......(....((((.(..........)).)))....)..)..).))))....(((((.((.......)).)))))......))...))))))).)).))..(.(..((.(.(((((.((..(.((((((((.(((..((.((((...(...((((.))).)...)...)))).))..))).)))))))))..)).)))))..).))...)..)..(((((((((....)))))))))}...... Subtomogram averaged consensus structure of the malarial 80S ribosome in Plasmodium falciparum-infected human erythrocytes; 18S ribosomal RNA 8tpu AA 3193 4.1 RF02543 URS0000868527_36329 0003735 0005840 36329 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.................<<<<<......<......>.......>>>>>..........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<...<<<.....<<<.<<<...<<<....>>>...>>>.>>>.....>>>.<<<..<<<<<<<<<<<....<<<<...<<<<.....<<<<......>>>>.((......<<<.....))>>>...>>>>...>>>>...>>>>>.>>>>>>..>>>..........<<<<<<<........>>>>>>>......<<<<<..[[((((>>>>>..>>>..................................<<....>>................<<<<....>>>>...................................<<.<<<<<<<<<.......<<<<<<<<<<<<<..>>>>>>>>>>>>>....<<<<<<<.<<<<<<...<..<<<<...<<<<<<<<.......<<<<......>>>>.<<<.<<<<<<........>>>>>>>>>...>>>>>>>>......>>>>..>...>>>>>>...........<<<<<<..<<<......>>>..>>>>>>.....>>>>>>>........>>>>>>>>>.>>..<<<<........>>>><<<<<<....<<<.<<<<<<<<<..<<<...<<<..........>>>....>>>...<<....>>..........<<<<<.....<<<...>>>......>>>>><<<<<<<<<<<....>>>.>>>>>.>>>...>>>>>>>>>.>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>....<<..<<.<<........>>>>.>>.....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<........<<.<<<<<<<.....<<<....<<<....<<<.<<<<..>>>>.>>>....>>>..>>.>.....>>>>>...<<<.<<<<<<.<.......>>>>>>>.>>>......>>>>....>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<....<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<..>>>>>>>>>>>>..........))).>>...>>>>>>.>>>....>>>>>><<<<<<<<<...<<<<<<..>>>>>>......>>>>>>>>>....>>>>>><<<<<<<..<<<......<<<<<<.<<....>>>>>>>>...>>>...>>>>>.>>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<.......>.>>>>>>....((<<<<<<...<<<<..<<<....>>>.......<<<<.>>>>.>>>>....>>...<<<<<........>>>>>))<<..<<<<<<<.<<<<...<<<....>>>...........((<<<<<<...<<<<.<<<<<<<<<..<<<<<<<...{{..>>>>>>....<<....<<<.<<<<<<.....<<<.....>>>.....>>>>>>.>>>.....<<<..<<<....>>>..>>>.>>.....<..<.<....>.>..>>..>>>.>>>>>>.>>>>.........>>>>>>.....<<<...<..>...>>>>>>>.>>>>>>>....>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>...<<<<....<<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<.<<<<<<<<<<<..>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<<....>>>>......>>>>>>>...<<..<<<..<<<<<<.<..<<<....<<<<......>>>>....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<..<<<<<<<<<<<<<<<<<..<>..>>>>>>.>>>>>>>>>>>...<<<<<.....<<<<....))>>>>...>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<.......>>>>>>>>>.<<<....>>>.>>))).......<<<<<<...<<<.))))...<<<<.....>>>>....]]>>>.>>>>>>..........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>........<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<.........>>>.....>>>>>..>...>>>.>.....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>......<<<.<<<..>>>..>>><<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<...<<<<<<<<<<}}..>>>>>..>>>>>...>>>>.>>>>>.<<<....<<<<<............>>>>>....>>>.>>>>.....>>>>>>>>><<<<<<<<<<.......<<<......<<.......<<<<<<<<>>>>>>>>.....>>......<<<..<<<<<<........>>>>>>..>>>.............>>>>>>>>>>>>><<<<.<<.............>>..<<<.<<<<<.<<<....<<<.<<..<<<<<.>>>>>..>>>>>...>>>....>>>>.>.>>>...>>>> .................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...((....((((.(((...((......))...))).)))....)))..(((..(((((((((((....((((...((.(...({..((......))..)[[(...).(((....}]])))...).))...))))...))))).))))))..))).....)....(((((((........)))))))......(((((..[[[[[[)))))..)))..................................((....)).............(..((((....)))).............).....................((.(((((((.(.......(((((((((.(((()))).)))))))).)...(((((((.((((((..((..((((...((((((((.......(((((....))))).(((.((((((..(....))))))))))...))))))))......))))..))..))))))...........((((((..(((......)))..)))))).....)))))))........).))))))).)).<((((........))))((((((....(((.(((((((((..(((...(((..........)))....)))...((....))..........(((((.....(((...)))......)))))(((((((((((....))).))))).)))...))))))))).)))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))....((..((.((........)))).))...).))))))))).(.((.......))...)..))))))......).))..((((((.....((((....)))).(((((((((........((.(((((((.....(((....(((..(.(((.((.(()).)).))).)..)))..)).).....)))))...(((.((((((.(.......))))))).)))......))))....))))))).))..((((.(((((.....))))).))))....(((......)))...((((((....((([[[...(.((((((......(..........(((.(((((((((()))))))))))))..........]]].)....))))))))))....))))))(((((((((...((((((..))))))......)))))))))....))))))((((((....((......((((((.((....))))))))...)).....)))).)).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....(.......)..)))))....[[(((.((...((((..(((....))).......((((.)))).))))....))...(((((........)))))]]((..(((((((.(((...((((....))).........(.[[((((((...((((.((((.((((..(((((((...{{..))))))(...((.....((.((((((.....(((.....))).....)))))).))......((...(((....)))...)).))....)...(.(....).)...)..))).).)))).))))(...)....))))))...)).((...(..)...))..))).)))))))....)).)))..)).....((......)).)))).((((.....))))..))))...((((....((((((((.((..(....(.......(((((....(.[..).....)))))((.((((((.((((..))))...)))))).))(...).......(((((((((.>.((.........))...(((((((.....((((....))))......))))))).].(((.(((..((((((.(...((....((((......))))....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))).))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((.((((((.((..()..)).))).))).)))))))...(((((.....((((....]]))))...))))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((((((((....{..))))))))).(((....))).))]]].].....((((((...(((.]]]]...((((.....))))....]]))).))))))....)}....))))..)))))).......(..(.(.((((((...((.......))...))))))...))...)........((((.((((((..(((((((((......))))))..))).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))....))..))).)))))......(((..(.().)...)))(((((((((..((((.(.((((((.....(....)....)))))).)(((((...((((...((((((((((}}..)))))..)))))...)))).))))).(((....((((..............))))....))).)))).....))))))))).(((((((((.......(((....(.((........((((((()))))))......))).....(((..(((......()......)))..))).............)))))))))))).((((.((..(.......)..))..(((.(((((.(((....(((.((..((((...))))..)))))...)))....)))).).)))...)))) Subtomogram averaged consensus structure of the malarial 80S ribosome in Plasmodium falciparum-infected human erythrocytes; 28S ribosomal RNA 8tpu AC 151 4.1 RF00002 0003735 0005840 36329 agcacagucuuaacgauggaugucuugguuccuacagcgaugaaggccgcagcaaaaugcgauacgcaaugaaaauugcagugacugaaucaucagaaugcugaauguaaacuacaccaauucccugggaauagugguacuccuacagaaa ............................................<<<<<<.((.....>>>.....<.<<<<..<<.)).>>.......>>>>..>...>>>....<<.....>><<<<<<<<<<.>>>>>>..>>>>............. ............................................((((((.[[.....))).....(.((((..((.]].)).......))))..)...)))....((.....))((((((((((.))))))..))))............. Subtomogram averaged consensus structure of the malarial 80S ribosome in Plasmodium falciparum-infected human erythrocytes; 5.8S ribosomal RNA 8tpu AB 118 4.1 RF00001 0003735 0005840 36329 gacucguucauacuacaguggauacaccagaucccaucagaacucugaaguuaagcacuguaaggcuuggcuaguacugaggugggagaccgcucgggaacaccaggugaugagucag <<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>.. ((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......(((((..((....)).))))).....)))))))))))))).. Subtomogram averaged consensus structure of the malarial 80S ribosome in Plasmodium falciparum-infected human erythrocytes; 5S ribosomal RNA 8tqx A 19 2.09 38383158 64320 ugaucugggcccaguauca ................... ................... Crystal structure of the Zika virus stem-loop A (SLA) bottom stem; Zika virus stem-loop A (SLA) bottom stem 8tqx D 19 2.09 38383158 64320 ugaucugggcccaguauca ................... ................... Crystal structure of the Zika virus stem-loop A (SLA) bottom stem; Zika virus stem-loop A (SLA) bottom stem 8tsv A 25 1.51 38383158 64320 cagacugcgagggcccucgaguuug ......................... ......................... Crystal structure of the Zika virus stem-loop A (SLA) top stem; Zika virus stem-loop A (SLA) top stem 8tsv B 25 1.51 38383158 64320 cagacugcgagggcccucgaguuug ......................... ......................... Crystal structure of the Zika virus stem-loop A (SLA) top stem; Zika virus stem-loop A (SLA) top stem 8tsv C 25 1.51 38383158 64320 cagacugcgagggcccucgaguuug ......................... ......................... Crystal structure of the Zika virus stem-loop A (SLA) top stem; Zika virus stem-loop A (SLA) top stem 8tsv D 25 1.51 38383158 64320 cagacugcgagggcccucgaguuug ......................... ......................... Crystal structure of the Zika virus stem-loop A (SLA) top stem; Zika virus stem-loop A (SLA) top stem 8ub7 G 13 3.2 39779855 2885909 ggggcaggcuggg ............. ............. Diversity-generating retroelement (DGR) ribonucleoprotein reverse transcriptase - Active state (N-occupied); Diversity-generating retroelement (DGR) RNA avd 8ub7 H 13 3.2 39779855 2885909 gugcccaucaccu ............. ............. Diversity-generating retroelement (DGR) ribonucleoprotein reverse transcriptase - Active state (N-occupied); Diversity-generating retroelement (DGR) RNA TR 8ub7 I 122 3.2 RF03022 39779855 2885909 uggcucugccaacgcuacggcuuggcgggcuuagguggucacgguucuguccugcuucggcgaacacguuacacgguucggcaaaacgucgauuacugaaaauggaaaggcggggccgacuu ..<<..<<<<<<.<<....>>>>>>>>.>>.......................<<....>>................<<<<<....<<<<.....<.......>....>>>>..>>>>>... ..((.(((((((.((....))))))))))).......................((....))..............(.(((((....((((.....(.......)....))))..)))))).. Diversity-generating retroelement (DGR) ribonucleoprotein reverse transcriptase - Active state (N-occupied); Diversity-generating retroelement (DGR) RNA Sp 8ub8 G 14 3.28 39779855 2885909 ggggcaggcuggga .............. .............. Diversity-generating retroelement (DGR) ribonucleoprotein reverse transcriptase - Pre-active State 1a; Diversity-generating retroelement (DGR) RNA avd 8ub8 H 13 3.28 39779855 2885909 gugcccaucaccu ............. ............. Diversity-generating retroelement (DGR) ribonucleoprotein reverse transcriptase - Pre-active State 1a; Diversity-generating retroelement (DGR) RNA TR 8ub8 I 116 3.28 RF03022 39779855 2885909 uggcucugccaacgcuacggcuuggcgggcuuagguggucagccgguucuguccugcuucggcgaaacgguucggcaaaacgucgauuacugaaaauggaaaggcggggccgacuu ..<<.<<<<<<<.<<....>>>>>>>>>>>.........................<<....>>........<<<<<....<<<<.....<.......>....>>>>..>>>>>... ..((.(((((((.((....))))))))))).........................((....))........(((((....((((.....(.......)....))))..)))))... Diversity-generating retroelement (DGR) ribonucleoprotein reverse transcriptase - Pre-active State 1a; Diversity-generating retroelement (DGR) RNA Sp 8ub9 G 13 3.07 39779855 2885909 ggggcaggcuggg ............. ............. Diversity-generating retroelement (DGR) ribonucleoprotein reverse transcriptase- Active state (N-empty) 1a; Diversity-generating retroelement (DGR) RNA avd 8ub9 H 13 3.07 39779855 2885909 gugcccaucaccu ............. ............. Diversity-generating retroelement (DGR) ribonucleoprotein reverse transcriptase- Active state (N-empty) 1a; Diversity-generating retroelement (DGR) RNA TR 8ub9 I 122 3.07 RF03022 39779855 2885909 uggcucugccaacgcuacggcuuggcgggcuuagguggucacgguucuguccugcuucggcgaacacguuacacgguucggcaaaacgucgauuacugaaaauggaaaggcggggccgacuu ..<<..<<<<<<.<<....>>>>>>>>.>>.......................<<....>>................<<<<<....<<<<.....<.......>....>>>>..>>>>>... ..((.(((((((.((....))))))))))).......................((....))..............(.(((((....((((.....(.......)....))))..)))))).. Diversity-generating retroelement (DGR) ribonucleoprotein reverse transcriptase- Active state (N-empty) 1a; Diversity-generating retroelement (DGR) RNA Sp 8uba G 14 3.2 39779855 2885909 ggggcaggcuggga .............. .............. Diversity-generating retroelement (DGR) ribonucleoprotein reverse transcriptase - Pre-active state 1b; Diversity-generating retroelement (DGR) RNA avd 8uba H 13 3.2 39779855 2885909 gugcccaucaccu ............. ............. Diversity-generating retroelement (DGR) ribonucleoprotein reverse transcriptase - Pre-active state 1b; Diversity-generating retroelement (DGR) RNA TR 8uba I 116 3.2 RF03022 39779855 2885909 uggcucugccaacgcuacggcuuggcgggcuuagguggucagccgguucuguccugcuucggcgaaacgguucggcaaaacgucgauuacugaaaauggaaaggcggggccgacuu ..<<..<<<<<<.<<....>>>>>>>>.>>.........................<<....>>........<<<<<....<<<<.....<.......>....>>>>..>>>>>... ..((.(((((((.((....))))))))))).........................((....))......(.(((((....((((.....(.......)....))))..)))))).. Diversity-generating retroelement (DGR) ribonucleoprotein reverse transcriptase - Pre-active state 1b; Diversity-generating retroelement (DGR) RNA Sp 8ubb G 13 3.23 39779855 2885909 ggggcaggcuggg ............. ............. Diversity-generating retroelement (DGR) ribonucleoprotein reverse transcriptase - Active State (N-empty) 1b; Diversity-generating retroelement (DGR) RNA avd 8ubb H 13 3.23 39779855 2885909 augcccaucaccu ............. ............. Diversity-generating retroelement (DGR) ribonucleoprotein reverse transcriptase - Active State (N-empty) 1b; Diversity-generating retroelement (DGR) RNA TR 8ubb I 122 3.23 RF03022 39779855 2885909 uggcucugccaacgcuacggcuuggcgggcuuagguggucacgguucuguccugcuucggcgaacacguuacacgguucggcaaaacgucgauuacugaaaauggaaaggcggggccgacuu ..<<..<<<<<<.<<....>>>>>>>>.>>.......................<<....>>................<<<<<....<<<<.....<.......>....>>>>..>>>>>... ..((.(((((((.((....))))))))))).......................((....))..............(.(((((....((((.....(.......)....))))..)))))).. Diversity-generating retroelement (DGR) ribonucleoprotein reverse transcriptase - Active State (N-empty) 1b; Diversity-generating retroelement (DGR) RNA Sp 8ubc I 86 3.29 RF03022 39779855 2885909 uggcucugccaacgcuacggcuuggcgggcuuaggugggguucggcaaaacgucgauuacugaaaauggaaaggcggggccgacuu ..<<..<<<<<<.<<....>>>>>>>>.>>...........<<<<<....<<<<.....<.......>....>>>>..>>>>>... ..((.(((((((.((....))))))))))).........(.(((((....((((.....(.......)....))))..)))))).. Diversity-generating retroelement (DGR) ribonucleoprotein reverse transcriptase - Resting State 1b; Diversity-generating retroelement (DGR) RNA Sp 8ubd G 13 3.05 39779855 2885909 ggggcaggcuggg ............. ............. Diversity-generating retroelement (DGR) ribonucleoprotein reverse transcriptase - Pre-active State 2; Diversity-generating retroelement (DGR) RNA avd 8ubd H 13 3.05 39779855 2885909 gugcccaucaccu ............. ............. Diversity-generating retroelement (DGR) ribonucleoprotein reverse transcriptase - Pre-active State 2; Diversity-generating retroelement (DGR) RNA TR 8ubd I 123 3.05 RF03022 39779855 2885909 uggcucugccaacgcuacggcuuggcgggcuuagguggucagcgguucuguccugcuucggcgaacacguuacacgguucggcaaaacgucgauuacugaaaauggaaaggcggggccgacuu ..<<..<<<<<..<<....>>.>>>>>.>>........................<<....>>................<<<<<....<<<<.....<.......>....>>>>..>>>>>... ..((.(((((((.((....)))))))))))........................((....))..............(.(((((....((((.....(.......)....))))..)))))).. Diversity-generating retroelement (DGR) ribonucleoprotein reverse transcriptase - Pre-active State 2; Diversity-generating retroelement (DGR) RNA Sp 8ube G 11 3.05 39779855 2885909 ggcaggcuggg ........... ........... Diversity-generating retroelement (DGR) ribonucleoprotein reverse transcriptase - Resting State 1a; Diversity-generating retroelement (DGR) RNA avd 8ube H 17 3.05 39779855 2885909 ugcccaucaccuucuug ................. ................. Diversity-generating retroelement (DGR) ribonucleoprotein reverse transcriptase - Resting State 1a; Diversity-generating retroelement (DGR) RNA TR 8ube I 139 3.05 RF03022 39779855 2885909 cauggcucugccaacgcuacggcuuggcgggcuggccuuuccucaauagguggucagccgguucuguccugcuucggcgaacacguuacacgguucggcaaaacgucgauuacugaaaauggaaaggcggggccgacuu ....<<..<<<<<<.<<....>>>>>>>>.>>......................................<......>................<<<<<....<<<<.....<.......>....>>>>..>>>>>... ....((.(((((((.((....)))))))))))......................................(......)..............(.(((((....((((.....(.......)....))))..)))))).. Diversity-generating retroelement (DGR) ribonucleoprotein reverse transcriptase - Resting State 1a; Diversity-generating retroelement (DGR) RNA Sp 8ubf H 10 3.61 39779855 2885909 augcccauca .......... .......... Diversity-generating retroelement (DGR) ribonucleoprotein - Resting state 1c; Diversity-generating retroelement (DGR) RNA TR 8ubf I 92 3.61 RF03022 39779855 2885909 uggcucugccaacgcuacggcuuggcgggcugguggucauacacgguucggcaaaacgucgauuacugaaaauggaaaggcggggccgacuu ..<<..<<<<<<.<<....>>>>>>>>.>>.................<<<<<....<<<<.....<.......>....>>>>..>>>>>... ..((.(((((((.((....)))))))))))...............(.(((((....((((.....(.......)....))))..)))))).. Diversity-generating retroelement (DGR) ribonucleoprotein - Resting state 1c; Diversity-generating retroelement (DGR) RNA Sp 8ud3 G 17 2.67 38613382 2697049 uuuuuuuuuuuuuuuuu ................. ................. SARS-CoV-2 Nsp15 bound to poly(A/U) RNA, consensus form; RNA (35-MER) 8ud3 H 17 2.67 38613382 2697049 aaaaaaaaaaaaaaaaa ................. ................. SARS-CoV-2 Nsp15 bound to poly(A/U) RNA, consensus form; RNA (35-MER) 8ud4 G 23 3.25 38613382 2697049 uuuuuuuuuuuuuuuuuuuuguc ....................... ....................... SARS-CoV-2 Nsp15 bound to poly(A/U) RNA, state 1; RNA (35-MER) 8ud4 H 23 3.25 38613382 2697049 gacaaaaaaaaaaaaaaaaaaaa ....................... ....................... SARS-CoV-2 Nsp15 bound to poly(A/U) RNA, state 1; RNA (35-MER) 8ud5 G 27 3.13 38613382 2697049 uuuuuuuuuuuuuuuuuuuugucauuc ........................... ........................... SARS-CoV-2 Nsp15 bound to poly(A/U) RNA, state 2; RNA (35-MER) 8ud5 H 27 3.13 38613382 2697049 gaaugacaaaaaaaaaaaaaaaaaaaa ........................... ........................... SARS-CoV-2 Nsp15 bound to poly(A/U) RNA, state 2; RNA (35-MER) 8ud6 1A 2871 2.7 RF02541 38359125 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<.....<<<........>>>......>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..<<<.....(.>>>...>>>.........<<......>>.).>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<.......<<<<<<<....>>>>>>>....>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((..(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((.(..(((..........))..))..)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((..((.........))...))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(......[..(((((..(((......((((((((....))))))))...)))..........].)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((...)))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with cresomycin, mRNA, deacylated A-site tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.70A resolution; 23S Ribosomal RNA 8ud6 1B 120 2.7 RF00001 38359125 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> (((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).))))))))))) Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with cresomycin, mRNA, deacylated A-site tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.70A resolution; 5S Ribosomal RNA 8ud6 1a 1500 2.7 RF00177,RF01959,RF02542,RF01960 38359125 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<......>>....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((((((....))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((..((((....))))..))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((.(((....))).)))....(((....)))....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with cresomycin, mRNA, deacylated A-site tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.70A resolution; 16S Ribosomal RNA 8ud6 1v 13 2.7 38359125 10665 aaaaauguucuaa ............. ............. Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with cresomycin, mRNA, deacylated A-site tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.70A resolution; MF-mRNA 8ud6 1w 72 2.7 RF00005 URS00005AA258_562 38359125 0030533 0006412 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcac <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.. .((((((..((((...[..)))).((((.........)))).....(((((..]....)))))))))))... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with cresomycin, mRNA, deacylated A-site tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.70A resolution; A- and E-site Deacylated tRNAphe 8ud6 1x 76 2.7 RF00005 38359125 0030533 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaaccn <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with cresomycin, mRNA, deacylated A-site tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.70A resolution; P-site Aminoacyl-tRNA fMet-tRNAmet 8ud6 1y 74 2.7 RF00005 38359125 0030533 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[..)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with cresomycin, mRNA, deacylated A-site tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.70A resolution; A- and E-site Deacylated tRNAphe 8ud6 2A 2800 2.7 RF02541 38359125 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<.<......>.>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<..>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((..))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...((((((((.....(............)......))))))))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((((((()))))))))).))..........]]].)....))))))))))...)))))))(((((((..)))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(......[..(((((..((.......((((((((....))))))))....))..........].)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))((((.))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with cresomycin, mRNA, deacylated A-site tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.70A resolution; 23S Ribosomal RNA 8ud6 2B 120 2.7 RF00001 38359125 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with cresomycin, mRNA, deacylated A-site tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.70A resolution; 5S Ribosomal RNA 8ud6 2a 1503 2.7 RF00177,RF01959,RF02542,RF01960 38359125 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggau .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<......>>....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<..<.<<<<<<<........>>>>>>>>...>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...((((((......))))))....(.(....).)....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.(.((....)).)).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with cresomycin, mRNA, deacylated A-site tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.70A resolution; 16S Ribosomal RNA 8ud6 2v 13 2.7 38359125 10665 aaaaauguucuaa ............. ............. Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with cresomycin, mRNA, deacylated A-site tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.70A resolution; MF-mRNA 8ud6 2w 70 2.7 RF00005 URS00005AA258_562 38359125 0030533 0006412 562 cccgganagcucagggagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcac <<<<<<..<<<<.....>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>... ((((((..((((...[.)))).((((.........)))).....(((((..]....)))))))))))... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with cresomycin, mRNA, deacylated A-site tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.70A resolution; A- and E-site Deacylated tRNAphe 8ud6 2x 76 2.7 RF00005 38359125 0030533 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaaccn <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with cresomycin, mRNA, deacylated A-site tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.70A resolution; P-site Aminoacyl-tRNA fMet-tRNAmet 8ud6 2y 73 2.7 RF00005 38359125 0030533 562 gcccgganagcucagggagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<.....>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[.)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with cresomycin, mRNA, deacylated A-site tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.70A resolution; A- and E-site Deacylated tRNAphe 8ud7 1A 2871 2.55 RF02541 URS00001698E8_300852 38359125 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacganaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<.....<<<........>>>......>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..<<<.....(.>>>...>>>.........<<......>>.).>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<.<<....>>.>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<...>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((..(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...((((((((.(..(((..........))..))..))))))))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((..((.........))...))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(......[..(((((..(((......((((((((....))))))))...)))..........].)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..(((...)))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the A2058-N6-dimethylated Thermus thermophilus 70S ribosome in complex with cresomycin, mRNA, deacylated A-site tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.70A resolution; 23S Ribosomal RNA 8ud7 1B 120 2.55 RF00001 38359125 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> (((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).))))))))))) Crystal structure of the A2058-N6-dimethylated Thermus thermophilus 70S ribosome in complex with cresomycin, mRNA, deacylated A-site tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.70A resolution; 5S Ribosomal RNA 8ud7 1a 1500 2.55 RF00177,RF01959,RF02542,RF01960 38359125 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<......>>....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((((((....))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((..((((....))))..))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((.(((....))).)))....(((....)))....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the A2058-N6-dimethylated Thermus thermophilus 70S ribosome in complex with cresomycin, mRNA, deacylated A-site tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.70A resolution; 16S Ribosomal RNA 8ud7 1v 13 2.55 38359125 10665 aaaaauguucuaa ............. ............. Crystal structure of the A2058-N6-dimethylated Thermus thermophilus 70S ribosome in complex with cresomycin, mRNA, deacylated A-site tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.70A resolution; MF-mRNA 8ud7 1w 72 2.55 RF00005 URS00005AA258_562 38359125 0030533 0006412 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcac .<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>... .((((((..((((...[..)))).((((.........)))).....(((((..]....)))))))))))... Crystal structure of the A2058-N6-dimethylated Thermus thermophilus 70S ribosome in complex with cresomycin, mRNA, deacylated A-site tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.70A resolution; A- and E-site Deacylated tRNAphe 8ud7 1x 76 2.55 RF00005 38359125 0030533 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaaccn <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the A2058-N6-dimethylated Thermus thermophilus 70S ribosome in complex with cresomycin, mRNA, deacylated A-site tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.70A resolution; P-site Aminoacyl-tRNA fMet-tRNAmet 8ud7 1y 74 2.55 RF00005 38359125 0030533 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[..)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of the A2058-N6-dimethylated Thermus thermophilus 70S ribosome in complex with cresomycin, mRNA, deacylated A-site tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.70A resolution; A- and E-site Deacylated tRNAphe 8ud7 2A 2800 2.55 RF02541 URS00001698E8_300852 38359125 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacganaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<............>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<..>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((..))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((.(..((............).).)..)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((((((()))))))))).))..........]]].)....))))))))))...)))))))(((((((())))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(......[..(((((..(((......((((((((....))))))))...)))..........].)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....))))))).(((.))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the A2058-N6-dimethylated Thermus thermophilus 70S ribosome in complex with cresomycin, mRNA, deacylated A-site tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.70A resolution; 23S Ribosomal RNA 8ud7 2B 120 2.55 RF00001 38359125 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the A2058-N6-dimethylated Thermus thermophilus 70S ribosome in complex with cresomycin, mRNA, deacylated A-site tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.70A resolution; 5S Ribosomal RNA 8ud7 2a 1503 2.55 RF00177,RF01959,RF02542,RF01960 38359125 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggau .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<......>>....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((((((....))))))).(..(.(....).)..).)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.(.((....)).)).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}... Crystal structure of the A2058-N6-dimethylated Thermus thermophilus 70S ribosome in complex with cresomycin, mRNA, deacylated A-site tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.70A resolution; 16S Ribosomal RNA 8ud7 2v 13 2.55 38359125 10665 aaaaauguucuaa ............. ............. Crystal structure of the A2058-N6-dimethylated Thermus thermophilus 70S ribosome in complex with cresomycin, mRNA, deacylated A-site tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.70A resolution; MF-mRNA 8ud7 2w 69 2.55 RF00005 URS00005AA258_562 38359125 0030533 0006412 562 cccgganagcucagggagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggca <<<<<<..<<<<.....>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>.. ((((((..((((...[.)))).((((.........)))).....(((((..]....))))))))))).. Crystal structure of the A2058-N6-dimethylated Thermus thermophilus 70S ribosome in complex with cresomycin, mRNA, deacylated A-site tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.70A resolution; A- and E-site Deacylated tRNAphe 8ud7 2x 76 2.55 RF00005 38359125 0030533 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaaccn <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the A2058-N6-dimethylated Thermus thermophilus 70S ribosome in complex with cresomycin, mRNA, deacylated A-site tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.70A resolution; P-site Aminoacyl-tRNA fMet-tRNAmet 8ud7 2y 73 2.55 RF00005 38359125 0030533 562 gcccgganagcucagggagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<.....>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[.)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of the A2058-N6-dimethylated Thermus thermophilus 70S ribosome in complex with cresomycin, mRNA, deacylated A-site tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.70A resolution; A- and E-site Deacylated tRNAphe 8ud8 1A 2871 2.6 RF02541 38359125 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<....<<<..........>>..>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..<<......(..>>...>>>.........<<......>>.).>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<.......<<<<<<<....>>>>>>>....>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<...>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((..(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((.(..(((.(......).)..)))..)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((..((.........))...))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(......[..(((((..(((......((((((((....))))))))...)))..........].)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..((.....))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the A2503-C2,C8-dimethylated Thermus thermophilus 70S ribosome in complex with cresomycin, mRNA, deacylated A-site tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.70A resolution; 23S Ribosomal RNA 8ud8 1B 120 2.6 RF00001 38359125 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> (((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).))))))))))) Crystal structure of the A2503-C2,C8-dimethylated Thermus thermophilus 70S ribosome in complex with cresomycin, mRNA, deacylated A-site tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.70A resolution; 5S Ribosomal RNA 8ud8 1a 1500 2.6 RF00177,RF01959,RF02542,RF01960 38359125 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>.<..<<......>>.>..>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((..)))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((..((((....))))..))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((((((....)))))))....(((....)))....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the A2503-C2,C8-dimethylated Thermus thermophilus 70S ribosome in complex with cresomycin, mRNA, deacylated A-site tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.70A resolution; 16S Ribosomal RNA 8ud8 1v 13 2.6 38359125 10665 aaaaauguucuaa ............. ............. Crystal structure of the A2503-C2,C8-dimethylated Thermus thermophilus 70S ribosome in complex with cresomycin, mRNA, deacylated A-site tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.70A resolution; MF-mRNA 8ud8 1w 74 2.6 RF00005 38359125 0030533 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (.(((((..((((...[..)))).((((.........)))).....(((((..]....)))))))))).).... Crystal structure of the A2503-C2,C8-dimethylated Thermus thermophilus 70S ribosome in complex with cresomycin, mRNA, deacylated A-site tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.70A resolution; A- and E-site Deacylated tRNAphe 8ud8 1x 76 2.6 RF00005 38359125 0030533 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaaccn <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the A2503-C2,C8-dimethylated Thermus thermophilus 70S ribosome in complex with cresomycin, mRNA, deacylated A-site tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.70A resolution; P-site Aminoacyl-tRNA fMet-tRNAmet 8ud8 1y 74 2.6 RF00005 38359125 0030533 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((......)))).((((.........)))).....(((((.......)))))))))))).... Crystal structure of the A2503-C2,C8-dimethylated Thermus thermophilus 70S ribosome in complex with cresomycin, mRNA, deacylated A-site tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.70A resolution; A- and E-site Deacylated tRNAphe 8ud8 2A 2800 2.6 RF02541 38359125 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<....<<............>.>....>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<..>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<.......<<<<<<<<....>>>>>>>>....>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...((((((((.....))))))))....{.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).))))....(((((((((.[.....)))))))))....}.(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((..))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...((((((((.(..((............).).)..))))))))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((((((()))))))))).))..........]]].)....))))))))))...)))))))(((((((..)))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........(((((..(.(......((((((((....))))))))...).)............)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....))))))).((...)).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the A2503-C2,C8-dimethylated Thermus thermophilus 70S ribosome in complex with cresomycin, mRNA, deacylated A-site tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.70A resolution; 23S Ribosomal RNA 8ud8 2B 120 2.6 RF00001 38359125 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the A2503-C2,C8-dimethylated Thermus thermophilus 70S ribosome in complex with cresomycin, mRNA, deacylated A-site tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.70A resolution; 5S Ribosomal RNA 8ud8 2a 1503 2.6 RF00177,RF01959,RF02542,RF01960 38359125 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggau .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<......>>....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((.(....).)))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((((((....))))))).(..(((....)))..).)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.(.((....)).)).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}... Crystal structure of the A2503-C2,C8-dimethylated Thermus thermophilus 70S ribosome in complex with cresomycin, mRNA, deacylated A-site tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.70A resolution; 16S Ribosomal RNA 8ud8 2v 13 2.6 38359125 10665 aaaaauguucuaa ............. ............. Crystal structure of the A2503-C2,C8-dimethylated Thermus thermophilus 70S ribosome in complex with cresomycin, mRNA, deacylated A-site tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.70A resolution; MF-mRNA 8ud8 2w 72 2.6 RF00005 URS00005AA258_562 38359125 0030533 0006412 562 cccgganagcucagggagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<..<<<<.....>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((...[.)))).((((.........)))).....(((((..]....)))))))))))..... Crystal structure of the A2503-C2,C8-dimethylated Thermus thermophilus 70S ribosome in complex with cresomycin, mRNA, deacylated A-site tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.70A resolution; A- and E-site Deacylated tRNAphe 8ud8 2x 76 2.6 RF00005 38359125 0030533 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaaccn <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the A2503-C2,C8-dimethylated Thermus thermophilus 70S ribosome in complex with cresomycin, mRNA, deacylated A-site tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.70A resolution; P-site Aminoacyl-tRNA fMet-tRNAmet 8ud8 2y 73 2.6 RF00005 38359125 0030533 562 gcccgganagcucagggagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<.....>>>>.<<<<<<<...>>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[.)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of the A2503-C2,C8-dimethylated Thermus thermophilus 70S ribosome in complex with cresomycin, mRNA, deacylated A-site tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.70A resolution; A- and E-site Deacylated tRNAphe 8ukb L5 3740 3.05 RF02540,RF02541,RF02543 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcggcccggcggaucuuucccgcgcgggggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucgggggcccccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcgcucuccccccucccggcgcgccggggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccgggggaggccacgcgcgcgucccccgaagagggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcagacccgacgcccgccacgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagcggcggccggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcugggucggucgcggccggcgccuagcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacaugagagguguagaauaagugggaggcccccggcgccgguccgccggcccugcgggccgccggugaaauaccacuacucugaucguuuuuucacugacccggugaggcgggggggcgagccccgaggggcucucgcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccggucccccgccgggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<...<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>...<<<<<<<<<<...<<<<<<<<........<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>...>>>>>>>>..>>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<<<..<<<<<<<..<..<.<<....<<<<.<<<..<<<....>>>>>>>>>>>>.>.>..>>>>...>>>>>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<<<<<<<<<<<<<<<<<...<<..<<<....<<<<......<<<<<<<<..>>>>>>>>.......>>>>...>>>........>>>>>>..>>>>>>>>>>>....................<<<<<<.<<<<<<<............>>>>>>>.<<<<<<.<<<<.<<<<<<<<<<<.<<<<<.<<<<.<<...........>.>.>>>>.>>>>>.>.>>>>>>>.>>>...>>>>..>>>>.>>..<<<<<<<<<<.....>>>>>>>>.>>....>>>>>>.....>>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<......>>>>>>>..<<<<<...<<<..<<<..[[...((((>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<......................<<<.<<<<<<<<<...<<<....<<<..<.<<<<.<..................>>>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.........>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<..........))))...]]...........................>>>>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<...........>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<..<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<.<<<<<<<<<<<...<..........>........>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<<..<<<............................................................................>.>>...>>>>>>>>...<<<<<.....<<<<.....<..<<.....>.>..>................<<<<<<<<<<.......>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>>.<<<....>>>.>>)))].....<<<<<<<..<<<..)))))).>>>>>>>>>>.........>>>>..>>>>>>.......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<]]].>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.....<<<<<<<.<<..<<<<....<<<........<<<<<.<<<<....>>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>..............>>>>..>>>>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<.<..<<<<<......>>>>>..>>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((...((((((((((.....)))))).)))).....)))....((((((((((...((((((((.(......((((((((..({((((......)))))....[[(...).(((....}]])))...).)))))))..)))))))))..))))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....(((((((((((..(((((((...((..((....((((.((....(......)..))))))).).))..))))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((..(.((((........((((((())))))).........))))..))))........))))))..)))))))))))....................((((((.((((((.....(.....)..)))))).((((((.((((.((((((((((..(((((.((((.(..............).)))).)))))...))))))).)))...))))..)))).))..((((((((((.....)))))))).))..[.)))))).....))).)))))...)))))...)))))))).<((((........))))((((((....(((((((((((((..(((..(((((........))))..)..)))...((....))...(((((((......)))))))..(((((...(((..(((..[[.....[[)))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((......................(((.((((((((....(((....(((..(.((((.(..(.............).))))).)..)))..)).)....))))))...(((((((((.(......))))))))))....))))))))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[.....(.(((((......(..........(((.((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....)))))).)))...)))))))((((((.(((..........]].....]]]..(.....).................)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...((....(((....)))..........((.((((....(....)...))))))......))....))...(((((........)))))]]((((....(((((...((.((((....)))).))..((((....)))...(...((((((...(((((((((((((((((((((((..{{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....(((((((.......))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((...(([...)...])........)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........))))).(.)....((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.(.......((((.((((((..(((((.(.(((((((.(((((.((..........................(...............................).............................)).)))))...(((((.....((((.....((...(.....)..))................((((((((((.......))))))))))..))))..)))))....))))))).)..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a..)..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}}.)))))..)).))...))))...)))).((((...((((.....}.......))))...))))..)))...).)))))).....((((((..((..((((.(..(((........(((((.((((.(.))))).))))).......)))...(((...((......(((.(((((((......))))))))).)....))...)))...........)..))))..)).))))))(((((.(..(.......)..)....((.(((((((.((.....((((.(..(((((......)))))..)))))....))....)))).))).))..))))).. In situ HHT and CHX treated human hibernating state without E-tRNA 80S ribosome; 28S rRNA 8ukb L7 120 3.05 RF00001 0003735 0005840 9606 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. In situ HHT and CHX treated human hibernating state without E-tRNA 80S ribosome; 5S rRNA [Homo sapiens] 8ukb L8 156 3.05 RF00002,RF02540 0003735 0005840 9606 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<<<<....>>>>.....<.<<<......>>.............>>>..>...>>>....<<<..>>><<<<<<<<<.....>>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))((((((((.......)))))))).................... In situ HHT and CHX treated human hibernating state without E-tRNA 80S ribosome; 5.8S rRNA [Homo sapiens] 8ukb S2 1740 3.05 RF01960,RF02542,RF01959,RF00177 URS00005A14E2_9606 0003735 0005840 9606 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucgcuccucucccacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgccccccguggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcgggcguccccgcccucucggccggggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggucggcccacggcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<....<<....<<<<<.........<........<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<........>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<<......>>>>>>>>.>>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>..>>>..>...>>.>.....<<.<<<<<<.<<<....>>>.>>.>>>>..>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<.......................<<................>>...<<<<<<.<.......<<...<.......>.<<<<.......>>>>...>>......>.>>>..>>>........<.<<.<<<.<<<...............>>>.>>>.>>.>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<.......>>>>.>>>>.....>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>.........<<.<<<<<..........>>>>>>>.........>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....(..<<.(..<<<<.<<....<<.<<<<<.<<<..<<<<.<<...<<<<<...<<<...>...............>>>.....>>>>>...>>.>>>>..>>>.>>>>>>>....>>.>>>>...).>>...).....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..(.....(((((...((.............((.....((.(.(.....).).))......))......))...((...((((........))))...))..((..(((((...(......)..)))))......)).(.((((.((((......))))))))))).)))....)).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).).....((.(.((((.(((....))).)).)).)..))......((..(...........)..)).........((((([[....(.((((.....((..]])).......))))))))))..)))))).)))..[......(.([[...(.(.((...(((..(.......................((................))...((((((.(.......((..((.......)).(((.......)))....))......).)))..)))........(.((.(.(..(.................)..).).)).)....)....(((.(((..(...((((..((..((((((((...((........))......))))))))..)).......((....))...))))..)..)))..))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.((((......)))))))))).)..)))...((..]]))...))...].))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))........(.(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((...(...((((..((((((((((((.......)))).)))).....))))..))))..).....(((((.....)))))........)))....))).))).....).))))).....).))))))..)).)))).))).(...((.(((........(.......((..((((....))))..))....).........))).))......(.....(((((..........))))).....)..)..))))).....(.(((.((.......)).))).)......))...)))))))))).))..(.(..((.(..((((.((..(.(..((((..(((..((((.((...((.((...((...(............)....)).....)).))...)).))))..)))..)))).).)..)).))))...).))...)..)..(((((((((....)))))))))}........ In situ HHT and CHX treated human hibernating state without E-tRNA 80S ribosome; 18S rRNA 8upo 7 28 5.5 39117885 32630 auguuuuuuuuuuugauuuggugagagg ............................ ............................ Escherichia coli transcription-translation coupled complex class A (TTC-A) containing RfaH bound to ops signal, mRNA with a 21 nt long spacer, and fMet-tRNAs in E-site and P-site of the ribosome; mRNA with 21 nt long spacer 8upo A 76 5.5 RF00005 39117885 0030533 562 cgcgggguggagcagccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((........)))).(((((.......))))).....(((((.......)))))))))))..... Escherichia coli transcription-translation coupled complex class A (TTC-A) containing RfaH bound to ops signal, mRNA with a 21 nt long spacer, and fMet-tRNAs in E-site and P-site of the ribosome; E-site and P-site tRNA (fMet) 8upo B 76 5.5 RF00005 39117885 0030533 562 cgcgggguggagcagccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((........)))).(((((.......))))).....(((((.......)))))))))))..... Escherichia coli transcription-translation coupled complex class A (TTC-A) containing RfaH bound to ops signal, mRNA with a 21 nt long spacer, and fMet-tRNAs in E-site and P-site of the ribosome; E-site and P-site tRNA (fMet) 8upo D 1524 5.5 RF00177,RF01959,RF02542,RF01960 URS00000ABFE9_562 39117885 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccggccagcagcccgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgauaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgccguacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgaacaagguaaccguaggggccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<......>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>..<<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>>.<<<<<(((...<<<<<.......)))........>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<......>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<....<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>.>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>......<<..<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>....>>........<<<<<<<<<..>>>>>>>>>...... ........((((..[.[[[[.)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((........))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..........)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((((.......)))))))).....)....)))))....)..((((([[[...(((((....(..]]]).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))..]]]].](((((.(((((((.((..(((((..((((((((((......((......))..........(((((((..(...((.((((..(((.(((....))).))).............))))..))).((.(.(...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..(..((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))....)...)..)..(((((((((..)))))))))}..... Escherichia coli transcription-translation coupled complex class A (TTC-A) containing RfaH bound to ops signal, mRNA with a 21 nt long spacer, and fMet-tRNAs in E-site and P-site of the ribosome; 16S rRNA 8upo a 2880 5.5 RF02541 39117885 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaacccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcggggcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacgguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccucccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccgaacaaacgguccuaagguagcgaaauccuugucggguaaguuccgacugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugagaugcaguguacccgcggcaagacggaaagaccccguaaccuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgggauaacaggcgauaccgcccaagaguucauaucgacggcgguguuuggcacucggucggcucaucacauccuggggcugaaguaggucccaaggguauggcguucgccauuuaaagugguacgcgagcggguuuagaacgucgugagacagucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<.<....<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>..>>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>>.>>...............<<....>>....>>.........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<.....>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>>.>>...>>>>>>>.>...<<<<<<<<<.......>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....[[[...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<.....>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>.>......>>>>>>>>..>>>>..<<<<......>>>>.........<..........<<<<<<.....>>>>>>....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<.......>>>>>..<<<<<<<<.<<<.<<......<.<<..<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<..<<.......<<<<<<<<....>>>>>>>>....>>............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>..............>>>....>>>........<<...<<<<<<...<<.......>>...>>>>>>.....>>......<<.<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<....>>>>>.....>>>>>..>...>>.>>....<.<<<<<....>>>.>>>....>>..>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]].>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.....))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((.((.........))..))...)))).)))..)).).....))))))).))..)))))))).)...(((((((((.......)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{...((..(((..((((.......))))..))).....(..(((......))))..)).....)))..))))).))...........]]].)...))))))))))...)))))))(((((..((....))..)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((.(((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....)))).)))))).))).))).....((.....)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.((..(((((((..(((........(((((..((....))...)))))........))))))))..)))).(.(((......))).)........((.........(((((.......))))).)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((....]}.)))))..((((((((.(((.((......(.((.((((..(((((.(((.(((((.(((((((((((.(.((.(..........(((...(((.......(((((((....)))))))....))).............))).).)).).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((.....[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}.......)))..).)))......(.((.(.((((((...((.......))...))))))...).))..)....(.((.((((((..(((((((((......))))))..))).(((((....))))).....)))))..)...)).).....(.(((((....))).)))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((.(....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Escherichia coli transcription-translation coupled complex class A (TTC-A) containing RfaH bound to ops signal, mRNA with a 21 nt long spacer, and fMet-tRNAs in E-site and P-site of the ribosome; 23S rRNA 8upo d 120 5.5 RF00001 39117885 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. .(((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))).. Escherichia coli transcription-translation coupled complex class A (TTC-A) containing RfaH bound to ops signal, mRNA with a 21 nt long spacer, and fMet-tRNAs in E-site and P-site of the ribosome; 5S rRNA 8upr 7 38 5.3 39117885 32630 auguuuuuuuuuuuuuuuuuuuuugauuuggugagagg ...................................... ...................................... Escherichia coli transcription-translation coupled complex class A (TTC-A) containing RfaH bound to ops signal, mRNA with a 21 nt long spacer, and fMet-tRNAs in E-site and P-site of the ribosome; mRNA with 21 nt long spacer 8upr A 76 5.3 RF00005 39117885 0030533 562 cgcgggguggagcagccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((........)))).(((((.......))))).....(((((.......)))))))))))..... Escherichia coli transcription-translation coupled complex class A (TTC-A) containing RfaH bound to ops signal, mRNA with a 21 nt long spacer, and fMet-tRNAs in E-site and P-site of the ribosome; E-site and P-site tRNA (fMet) 8upr B 76 5.3 RF00005 39117885 0030533 562 cgcgggguggagcagccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((........)))).(((((.......))))).....(((((.......)))))))))))..... Escherichia coli transcription-translation coupled complex class A (TTC-A) containing RfaH bound to ops signal, mRNA with a 21 nt long spacer, and fMet-tRNAs in E-site and P-site of the ribosome; E-site and P-site tRNA (fMet) 8upr D 1524 5.3 RF00177,RF01959,RF02542,RF01960 URS00000ABFE9_562 39117885 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccggccagcagcccgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgauaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgccguacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgaacaagguaaccguaggggccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<......>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>..<<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>>.<<<<<(((...<<<<<.......)))........>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<......>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<....<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>.>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>......<<..<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>....>>........<<<<<<<<<..>>>>>>>>>...... ........((((..[.[[[[.)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((........))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..........)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((((.......)))))))).....)....)))))....)..((((([[[...(((((....(..]]]).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))..]]]].](((((.(((((((.((..(((((..((((((((((......((......))..........(((((((..(...((.((((..(((.(((....))).))).............))))..))).((.(.(...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..(..((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))....)...)..)..(((((((((..)))))))))}..... Escherichia coli transcription-translation coupled complex class A (TTC-A) containing RfaH bound to ops signal, mRNA with a 21 nt long spacer, and fMet-tRNAs in E-site and P-site of the ribosome; 16S rRNA 8upr a 2880 5.3 RF02541 39117885 0003735 0005840 562 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<<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<.<....<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>..>>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>>.>>...............<<....>>....>>.........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<.....>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>>.>>...>>>>>>>.>...<<<<<<<<<.......>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....[[[...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<.....>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>.>......>>>>>>>>..>>>>..<<<<......>>>>.........<..........<<<<<<.....>>>>>>....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<.......>>>>>..<<<<<<<<.<<<.<<......<.<<..<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<..<<.......<<<<<<<<....>>>>>>>>....>>............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>..............>>>....>>>........<<...<<<<<<...<<.......>>...>>>>>>.....>>......<<.<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<....>>>>>.....>>>>>..>...>>.>>....<.<<<<<....>>>.>>>....>>..>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]].>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.....))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((.((.........))..))...)))).)))..)).).....))))))).))..)))))))).)...(((((((((.......)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{...((..(((..((((.......))))..))).....(..(((......))))..)).....)))..))))).))...........]]].)...))))))))))...)))))))(((((..((....))..)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((.(((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....)))).)))))).))).))).....((.....)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.((..(((((((..(((........(((((..((....))...)))))........))))))))..)))).(.(((......))).)........((.........(((((.......))))).)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((....]}.)))))..((((((((.(((.((......(.((.((((..(((((.(((.(((((.(((((((((((.(.((.(..........(((...(((.......(((((((....)))))))....))).............))).).)).).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((.....[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}.......)))..).)))......(.((.(.((((((...((.......))...))))))...).))..)....(.((.((((((..(((((((((......))))))..))).(((((....))))).....)))))..)...)).).....(.(((((....))).)))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((.(....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Escherichia coli transcription-translation coupled complex class A (TTC-A) containing RfaH bound to ops signal, mRNA with a 21 nt long spacer, and fMet-tRNAs in E-site and P-site of the ribosome; 23S rRNA 8upr d 120 5.3 RF00001 39117885 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. .(((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))).. Escherichia coli transcription-translation coupled complex class A (TTC-A) containing RfaH bound to ops signal, mRNA with a 21 nt long spacer, and fMet-tRNAs in E-site and P-site of the ribosome; 5S rRNA 8uql 7 37 3.2 39117885 32630 auguuuuuuuuuuuuuuuuuuuugauuuggugagagg ..................................... ..................................... Escherichia coli transcription-translation coupled complex class B (TTC-B) containing RfaH in loaded state, mRNA with a 24 nt long spacer, and fMet-tRNAs in E-site and P-site of the ribosome; mRNA with 24 nt long spacer 8uql A 76 3.2 RF00005 39117885 0030533 562 cgcgggguggagcagccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((........)))).(((((.......))))).....(((((.......)))))))))))..... Escherichia coli transcription-translation coupled complex class B (TTC-B) containing RfaH in loaded state, mRNA with a 24 nt long spacer, and fMet-tRNAs in E-site and P-site of the ribosome; E-site and P-site fMet-tRNA 8uql B 76 3.2 RF00005 39117885 0030533 562 cgcgggguggagcagccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((........)))).(((((.......))))).....(((((.......)))))))))))..... Escherichia coli transcription-translation coupled complex class B (TTC-B) containing RfaH in loaded state, mRNA with a 24 nt long spacer, and fMet-tRNAs in E-site and P-site of the ribosome; E-site and P-site fMet-tRNA 8uql D 1524 3.2 RF00177,RF01959,RF02542,RF01960 URS00000ABFE9_562 39117885 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccggccagcagcccgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgauaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgccguacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgaacaagguaaccguaggggccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<......>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>..<<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>>.<<<<<(((...<<<<<.......)))........>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<......>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<....<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>.>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>......<<..<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>....>>........<<<<<<<<<..>>>>>>>>>...... ........((((..[.[[[[.)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((........))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..........)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((((.......)))))))).....)....)))))....)..((((([[[...(((((....(..]]]).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))..]]]].](((((.(((((((.((..(((((..((((((((((......((......))..........(((((((..(...((.((((..(((.(((....))).))).............))))..))).((.(.(...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..(..((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))....)...)..)..(((((((((..)))))))))}..... Escherichia coli transcription-translation coupled complex class B (TTC-B) containing RfaH in loaded state, mRNA with a 24 nt long spacer, and fMet-tRNAs in E-site and P-site of the ribosome; 16S rRNA 8uql a 2880 3.2 RF02541 39117885 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaacccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcggggcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacgguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccucccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccgaacaaacgguccuaagguagcgaaauccuugucggguaaguuccgacugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugagaugcaguguacccgcggcaagacggaaagaccccguaaccuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgggauaacaggcgauaccgcccaagaguucauaucgacggcgguguuuggcacucggucggcucaucacauccuggggcugaaguaggucccaaggguauggcguucgccauuuaaagugguacgcgagcggguuuagaacgucgugagacagucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<.<....<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>..>>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>>.>>...............<<....>>....>>.........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<.....>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>>.>>...>>>>>>>.>...<<<<<<<<<.......>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....[[[...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<.....>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>.>......>>>>>>>>..>>>>..<<<<......>>>>.........<..........<<<<<<.....>>>>>>....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<.......>>>>>..<<<<<<<<.<<<.<<......<.<<..<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<..<<.......<<<<<<<<....>>>>>>>>....>>............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>..............>>>....>>>........<<...<<<<<<...<<.......>>...>>>>>>.....>>......<<.<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<....>>>>>.....>>>>>..>...>>.>>....<.<<<<<....>>>.>>>....>>..>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]].>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.....))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((.((.........))..))...)))).)))..)).).....))))))).))..)))))))).)...(((((((((.......)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{...((..(((..((((.......))))..))).....(..(((......))))..)).....)))..))))).))...........]]].)...))))))))))...)))))))(((((..((....))..)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((.(((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....)))).)))))).))).))).....((.....)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.((..(((((((..(((........(((((..((....))...)))))........))))))))..)))).(.(((......))).)........((.........(((((.......))))).)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((....]}.)))))..((((((((.(((.((......(.((.((((..(((((.(((.(((((.(((((((((((.(.((.(..........(((...(((.......(((((((....)))))))....))).............))).).)).).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((.....[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}.......)))..).)))......(.((.(.((((((...((.......))...))))))...).))..)....(.((.((((((..(((((((((......))))))..))).(((((....))))).....)))))..)...)).).....(.(((((....))).)))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((.(....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Escherichia coli transcription-translation coupled complex class B (TTC-B) containing RfaH in loaded state, mRNA with a 24 nt long spacer, and fMet-tRNAs in E-site and P-site of the ribosome; 23S rRNA 8uql d 120 3.2 RF00001 39117885 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. .(((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))).. Escherichia coli transcription-translation coupled complex class B (TTC-B) containing RfaH in loaded state, mRNA with a 24 nt long spacer, and fMet-tRNAs in E-site and P-site of the ribosome; 5S rRNA 8uqm 7 37 5.3 39117885 32630 auguuuuuuuuuuuuuuuuuuuugauuuggugagagg ..................................... ..................................... Escherichia coli transcription-translation coupled complex class B (TTC-B) containing RfaH in loaded state, NusA, mRNA with a 24 nt long spacer, and fMet-tRNAs in E-site and P-site of the ribosome; mRNA with 24 nt long spacer 8uqm A 76 5.3 RF00005 39117885 0030533 562 cgcgggguggagcagccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((........)))).(((((.......))))).....(((((.......)))))))))))..... Escherichia coli transcription-translation coupled complex class B (TTC-B) containing RfaH in loaded state, NusA, mRNA with a 24 nt long spacer, and fMet-tRNAs in E-site and P-site of the ribosome; E-site and P-site fMet-tRNA 8uqm B 76 5.3 RF00005 39117885 0030533 562 cgcgggguggagcagccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((........)))).(((((.......))))).....(((((.......)))))))))))..... Escherichia coli transcription-translation coupled complex class B (TTC-B) containing RfaH in loaded state, NusA, mRNA with a 24 nt long spacer, and fMet-tRNAs in E-site and P-site of the ribosome; E-site and P-site fMet-tRNA 8uqm D 1524 5.3 RF00177,RF01959,RF02542,RF01960 URS00000ABFE9_562 39117885 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccggccagcagcccgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgauaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgccguacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgaacaagguaaccguaggggccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<......>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>..<<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>>.<<<<<(((...<<<<<.......)))........>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<......>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<....<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>.>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>......<<..<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>....>>........<<<<<<<<<..>>>>>>>>>...... ........((((..[.[[[[.)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((........))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..........)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((((.......)))))))).....)....)))))....)..((((([[[...(((((....(..]]]).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))..]]]].](((((.(((((((.((..(((((..((((((((((......((......))..........(((((((..(...((.((((..(((.(((....))).))).............))))..))).((.(.(...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..(..((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))....)...)..)..(((((((((..)))))))))}..... Escherichia coli transcription-translation coupled complex class B (TTC-B) containing RfaH in loaded state, NusA, mRNA with a 24 nt long spacer, and fMet-tRNAs in E-site and P-site of the ribosome; 16S rRNA 8uqm a 2880 5.3 RF02541 39117885 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaacccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcggggcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacgguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccucccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccgaacaaacgguccuaagguagcgaaauccuugucggguaaguuccgacugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugagaugcaguguacccgcggcaagacggaaagaccccguaaccuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgggauaacaggcgauaccgcccaagaguucauaucgacggcgguguuuggcacucggucggcucaucacauccuggggcugaaguaggucccaaggguauggcguucgccauuuaaagugguacgcgagcggguuuagaacgucgugagacagucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<.<....<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>..>>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>>.>>...............<<....>>....>>.........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<.....>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>>.>>...>>>>>>>.>...<<<<<<<<<.......>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....[[[...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<.....>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>.>......>>>>>>>>..>>>>..<<<<......>>>>.........<..........<<<<<<.....>>>>>>....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<.......>>>>>..<<<<<<<<.<<<.<<......<.<<..<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<..<<.......<<<<<<<<....>>>>>>>>....>>............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>..............>>>....>>>........<<...<<<<<<...<<.......>>...>>>>>>.....>>......<<.<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<....>>>>>.....>>>>>..>...>>.>>....<.<<<<<....>>>.>>>....>>..>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]].>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.....))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((.((.........))..))...)))).)))..)).).....))))))).))..)))))))).)...(((((((((.......)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{...((..(((..((((.......))))..))).....(..(((......))))..)).....)))..))))).))...........]]].)...))))))))))...)))))))(((((..((....))..)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((.(((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....)))).)))))).))).))).....((.....)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.((..(((((((..(((........(((((..((....))...)))))........))))))))..)))).(.(((......))).)........((.........(((((.......))))).)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((....]}.)))))..((((((((.(((.((......(.((.((((..(((((.(((.(((((.(((((((((((.(.((.(..........(((...(((.......(((((((....)))))))....))).............))).).)).).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((.....[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}.......)))..).)))......(.((.(.((((((...((.......))...))))))...).))..)....(.((.((((((..(((((((((......))))))..))).(((((....))))).....)))))..)...)).).....(.(((((....))).)))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((.(....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Escherichia coli transcription-translation coupled complex class B (TTC-B) containing RfaH in loaded state, NusA, mRNA with a 24 nt long spacer, and fMet-tRNAs in E-site and P-site of the ribosome; 23S rRNA 8uqm d 120 5.3 RF00001 39117885 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. .(((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))).. Escherichia coli transcription-translation coupled complex class B (TTC-B) containing RfaH in loaded state, NusA, mRNA with a 24 nt long spacer, and fMet-tRNAs in E-site and P-site of the ribosome; 5S rRNA 8uqp 7 37 3.8 39117885 32630 auguuuuuuuuuuuuuuuuuuuugauuuggugagagg ..................................... ..................................... Escherichia coli transcription-translation coupled complex class B (TTC-B) containing RfaH bound to ops signal, mRNA with a 24 nt long spacer, and fMet-tRNAs in E-site and P-site of the ribosome; mRNA with 24 nt long spacer 8uqp A 76 3.8 RF00005 39117885 0030533 562 cgcgggguggagcagccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((........)))).(((((.......))))).....(((((.......)))))))))))..... Escherichia coli transcription-translation coupled complex class B (TTC-B) containing RfaH bound to ops signal, mRNA with a 24 nt long spacer, and fMet-tRNAs in E-site and P-site of the ribosome; E-site and P-site fMet-tRNA 8uqp B 76 3.8 RF00005 39117885 0030533 562 cgcgggguggagcagccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((........)))).(((((.......))))).....(((((.......)))))))))))..... Escherichia coli transcription-translation coupled complex class B (TTC-B) containing RfaH bound to ops signal, mRNA with a 24 nt long spacer, and fMet-tRNAs in E-site and P-site of the ribosome; E-site and P-site fMet-tRNA 8uqp D 1524 3.8 RF00177,RF01959,RF02542,RF01960 URS00000ABFE9_562 39117885 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccggccagcagcccgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgauaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgccguacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgaacaagguaaccguaggggccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<......>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>..<<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>>.<<<<<(((...<<<<<.......)))........>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<......>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<....<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>.>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>......<<..<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>....>>........<<<<<<<<<..>>>>>>>>>...... ........((((..[.[[[[.)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((........))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..........)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((((.......)))))))).....)....)))))....)..((((([[[...(((((....(..]]]).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))..]]]].](((((.(((((((.((..(((((..((((((((((......((......))..........(((((((..(...((.((((..(((.(((....))).))).............))))..))).((.(.(...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..(..((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))....)...)..)..(((((((((..)))))))))}..... Escherichia coli transcription-translation coupled complex class B (TTC-B) containing RfaH bound to ops signal, mRNA with a 24 nt long spacer, and fMet-tRNAs in E-site and P-site of the ribosome; 16S rRNA 8uqp a 2880 3.8 RF02541 39117885 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaacccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcggggcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacgguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccucccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccgaacaaacgguccuaagguagcgaaauccuugucggguaaguuccgacugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugagaugcaguguacccgcggcaagacggaaagaccccguaaccuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgggauaacaggcgauaccgcccaagaguucauaucgacggcgguguuuggcacucggucggcucaucacauccuggggcugaaguaggucccaaggguauggcguucgccauuuaaagugguacgcgagcggguuuagaacgucgugagacagucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<.<....<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>..>>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>>.>>...............<<....>>....>>.........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<.....>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>>.>>...>>>>>>>.>...<<<<<<<<<.......>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....[[[...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<.....>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>.>......>>>>>>>>..>>>>..<<<<......>>>>.........<..........<<<<<<.....>>>>>>....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<.......>>>>>..<<<<<<<<.<<<.<<......<.<<..<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<..<<.......<<<<<<<<....>>>>>>>>....>>............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>..............>>>....>>>........<<...<<<<<<...<<.......>>...>>>>>>.....>>......<<.<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<....>>>>>.....>>>>>..>...>>.>>....<.<<<<<....>>>.>>>....>>..>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]].>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.....))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((.((.........))..))...)))).)))..)).).....))))))).))..)))))))).)...(((((((((.......)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{...((..(((..((((.......))))..))).....(..(((......))))..)).....)))..))))).))...........]]].)...))))))))))...)))))))(((((..((....))..)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((.(((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....)))).)))))).))).))).....((.....)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.((..(((((((..(((........(((((..((....))...)))))........))))))))..)))).(.(((......))).)........((.........(((((.......))))).)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((....]}.)))))..((((((((.(((.((......(.((.((((..(((((.(((.(((((.(((((((((((.(.((.(..........(((...(((.......(((((((....)))))))....))).............))).).)).).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((.....[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}.......)))..).)))......(.((.(.((((((...((.......))...))))))...).))..)....(.((.((((((..(((((((((......))))))..))).(((((....))))).....)))))..)...)).).....(.(((((....))).)))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((.(....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Escherichia coli transcription-translation coupled complex class B (TTC-B) containing RfaH bound to ops signal, mRNA with a 24 nt long spacer, and fMet-tRNAs in E-site and P-site of the ribosome; 23S rRNA 8uqp d 120 3.8 RF00001 39117885 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. .(((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))).. Escherichia coli transcription-translation coupled complex class B (TTC-B) containing RfaH bound to ops signal, mRNA with a 24 nt long spacer, and fMet-tRNAs in E-site and P-site of the ribosome; 5S rRNA 8ur0 7 37 3.4 39117885 32630 auguuuuuuuuuuuuuuuuuuuugauuuggugagagg ..................................... ..................................... Escherichia coli transcription-translation coupled complex class B (TTC-B) containing RfaH bound to ops signal, NusA, mRNA with a 24 nt long spacer, and fMet-tRNAs in E-site and P-site of the ribosome; mRNA with 24 nt long spacer 8ur0 A 76 3.4 RF00005 39117885 0030533 562 cgcgggguggagcagccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((........)))).(((((.......))))).....(((((.......)))))))))))..... Escherichia coli transcription-translation coupled complex class B (TTC-B) containing RfaH bound to ops signal, NusA, mRNA with a 24 nt long spacer, and fMet-tRNAs in E-site and P-site of the ribosome; E-site and P-site fMet-tRNA 8ur0 B 76 3.4 RF00005 39117885 0030533 562 cgcgggguggagcagccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((........)))).(((((.......))))).....(((((.......)))))))))))..... Escherichia coli transcription-translation coupled complex class B (TTC-B) containing RfaH bound to ops signal, NusA, mRNA with a 24 nt long spacer, and fMet-tRNAs in E-site and P-site of the ribosome; E-site and P-site fMet-tRNA 8ur0 D 1524 3.4 RF00177,RF01959,RF02542,RF01960 URS00000ABFE9_562 39117885 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccggccagcagcccgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgauaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgccguacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgaacaagguaaccguaggggccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<......>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>..<<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>>.<<<<<(((...<<<<<.......)))........>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<......>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<....<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>.>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>......<<..<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>....>>........<<<<<<<<<..>>>>>>>>>...... ........((((..[.[[[[.)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((........))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..........)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((((.......)))))))).....)....)))))....)..((((([[[...(((((....(..]]]).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))..]]]].](((((.(((((((.((..(((((..((((((((((......((......))..........(((((((..(...((.((((..(((.(((....))).))).............))))..))).((.(.(...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..(..((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))....)...)..)..(((((((((..)))))))))}..... Escherichia coli transcription-translation coupled complex class B (TTC-B) containing RfaH bound to ops signal, NusA, mRNA with a 24 nt long spacer, and fMet-tRNAs in E-site and P-site of the ribosome; 16S rRNA 8ur0 a 2880 3.4 RF02541 39117885 0003735 0005840 562 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((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.....))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((.((.........))..))...)))).)))..)).).....))))))).))..)))))))).)...(((((((((.......)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{...((..(((..((((.......))))..))).....(..(((......))))..)).....)))..))))).))...........]]].)...))))))))))...)))))))(((((..((....))..)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((.(((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....)))).)))))).))).))).....((.....)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.((..(((((((..(((........(((((..((....))...)))))........))))))))..)))).(.(((......))).)........((.........(((((.......))))).)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((....]}.)))))..((((((((.(((.((......(.((.((((..(((((.(((.(((((.(((((((((((.(.((.(..........(((...(((.......(((((((....)))))))....))).............))).).)).).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((.....[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}.......)))..).)))......(.((.(.((((((...((.......))...))))))...).))..)....(.((.((((((..(((((((((......))))))..))).(((((....))))).....)))))..)...)).).....(.(((((....))).)))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((.(....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Escherichia coli transcription-translation coupled complex class B (TTC-B) containing RfaH bound to ops signal, NusA, mRNA with a 24 nt long spacer, and fMet-tRNAs in E-site and P-site of the ribosome; 23S rRNA 8ur0 d 120 3.4 RF00001 39117885 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. .(((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))).. Escherichia coli transcription-translation coupled complex class B (TTC-B) containing RfaH bound to ops signal, NusA, mRNA with a 24 nt long spacer, and fMet-tRNAs in E-site and P-site of the ribosome; 5S rRNA 8urb I 20 3.4 URS00029156A3_32630 36993498 32630 agcuauuaaaaucacagauu .................... .................... Porcine epidemic diarrhea virus complete core polymerase complex; RNA (33-MER) 8urb J 21 3.4 URS00029156DD_32630 36993498 32630 aaaaaucugugauuuuaauag ..................... ..................... Porcine epidemic diarrhea virus complete core polymerase complex; RNA (55-MER) 8urh 7 37 5.7 39117885 32630 auguuuuuuuuuuuuuuuuuuuugauuuggugagagg ..................................... ..................................... Escherichia coli transcription-translation coupled complex class B (TTC-B) containing RfaH bound to ops signal, mRNA with a 27 nt long spacer, and fMet-tRNAs in E-site and P-site of the ribosome; mRNA with 27 nt long spacer 8urh A 76 5.7 RF00005 39117885 0030533 562 cgcgggguggagcagccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((........)))).(((((.......))))).....(((((.......)))))))))))..... Escherichia coli transcription-translation coupled complex class B (TTC-B) containing RfaH bound to ops signal, mRNA with a 27 nt long spacer, and fMet-tRNAs in E-site and P-site of the ribosome; E-site and P-site fMet-tRNA 8urh B 76 5.7 RF00005 39117885 0030533 562 cgcgggguggagcagccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((........)))).(((((.......))))).....(((((.......)))))))))))..... Escherichia coli transcription-translation coupled complex class B (TTC-B) containing RfaH bound to ops signal, mRNA with a 27 nt long spacer, and fMet-tRNAs in E-site and P-site of the ribosome; E-site and P-site fMet-tRNA 8urh D 1524 5.7 RF00177,RF01959,RF02542,RF01960 URS00000ABFE9_562 39117885 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccggccagcagcccgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgauaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgccguacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgaacaagguaaccguaggggccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<......>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>..<<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>>.<<<<<(((...<<<<<.......)))........>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<......>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<....<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>.>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>......<<..<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>....>>........<<<<<<<<<..>>>>>>>>>...... ........((((..[.[[[[.)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((........))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..........)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((((.......)))))))).....)....)))))....)..((((([[[...(((((....(..]]]).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))..]]]].](((((.(((((((.((..(((((..((((((((((......((......))..........(((((((..(...((.((((..(((.(((....))).))).............))))..))).((.(.(...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..(..((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))....)...)..)..(((((((((..)))))))))}..... Escherichia coli transcription-translation coupled complex class B (TTC-B) containing RfaH bound to ops signal, mRNA with a 27 nt long spacer, and fMet-tRNAs in E-site and P-site of the ribosome; 16S rRNA 8urh a 2880 5.7 RF02541 39117885 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaacccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcggggcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacgguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccucccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccgaacaaacgguccuaagguagcgaaauccuugucggguaaguuccgacugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugagaugcaguguacccgcggcaagacggaaagaccccguaaccuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgggauaacaggcgauaccgcccaagaguucauaucgacggcgguguuuggcacucggucggcucaucacauccuggggcugaaguaggucccaaggguauggcguucgccauuuaaagugguacgcgagcggguuuagaacgucgugagacagucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu 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((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.....))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((.((.........))..))...)))).)))..)).).....))))))).))..)))))))).)...(((((((((.......)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{...((..(((..((((.......))))..))).....(..(((......))))..)).....)))..))))).))...........]]].)...))))))))))...)))))))(((((..((....))..)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((.(((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....)))).)))))).))).))).....((.....)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.((..(((((((..(((........(((((..((....))...)))))........))))))))..)))).(.(((......))).)........((.........(((((.......))))).)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((....]}.)))))..((((((((.(((.((......(.((.((((..(((((.(((.(((((.(((((((((((.(.((.(..........(((...(((.......(((((((....)))))))....))).............))).).)).).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((.....[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}.......)))..).)))......(.((.(.((((((...((.......))...))))))...).))..)....(.((.((((((..(((((((((......))))))..))).(((((....))))).....)))))..)...)).).....(.(((((....))).)))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((.(....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Escherichia coli transcription-translation coupled complex class B (TTC-B) containing RfaH bound to ops signal, mRNA with a 27 nt long spacer, and fMet-tRNAs in E-site and P-site of the ribosome; 23S rRNA 8urh d 120 5.7 RF00001 39117885 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. .(((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))).. Escherichia coli transcription-translation coupled complex class B (TTC-B) containing RfaH bound to ops signal, mRNA with a 27 nt long spacer, and fMet-tRNAs in E-site and P-site of the ribosome; 5S rRNA 8uri 7 37 5.3 39117885 32630 auguuuuuuuuuuuuuuuuuuuugauuuggugagagg ..................................... ..................................... Escherichia coli transcription-translation coupled complex class B (TTC-B) containing RfaH bound to ops signal, NusA, mRNA with a 27 nt long spacer, and fMet-tRNAs in E-site and P-site of the ribosome; mRNA with 27 nt long spacer 8uri A 76 5.3 RF00005 39117885 0030533 562 cgcgggguggagcagccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((........)))).(((((.......))))).....(((((.......)))))))))))..... Escherichia coli transcription-translation coupled complex class B (TTC-B) containing RfaH bound to ops signal, NusA, mRNA with a 27 nt long spacer, and fMet-tRNAs in E-site and P-site of the ribosome; E-site and P-site fMet-tRNA 8uri B 76 5.3 RF00005 39117885 0030533 562 cgcgggguggagcagccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((........)))).(((((.......))))).....(((((.......)))))))))))..... Escherichia coli transcription-translation coupled complex class B (TTC-B) containing RfaH bound to ops signal, NusA, mRNA with a 27 nt long spacer, and fMet-tRNAs in E-site and P-site of the ribosome; E-site and P-site fMet-tRNA 8uri D 1524 5.3 RF00177,RF01959,RF02542,RF01960 URS00000ABFE9_562 39117885 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccggccagcagcccgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgauaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgccguacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgaacaagguaaccguaggggccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<......>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>..<<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>>.<<<<<(((...<<<<<.......)))........>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<......>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<....<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>.>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>......<<..<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>....>>........<<<<<<<<<..>>>>>>>>>...... ........((((..[.[[[[.)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((........))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..........)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((((.......)))))))).....)....)))))....)..((((([[[...(((((....(..]]]).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))..]]]].](((((.(((((((.((..(((((..((((((((((......((......))..........(((((((..(...((.((((..(((.(((....))).))).............))))..))).((.(.(...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..(..((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))....)...)..)..(((((((((..)))))))))}..... Escherichia coli transcription-translation coupled complex class B (TTC-B) containing RfaH bound to ops signal, NusA, mRNA with a 27 nt long spacer, and fMet-tRNAs in E-site and P-site of the ribosome; 16S rRNA 8uri a 2880 5.3 RF02541 39117885 0003735 0005840 562 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((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.....))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((.((.........))..))...)))).)))..)).).....))))))).))..)))))))).)...(((((((((.......)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{...((..(((..((((.......))))..))).....(..(((......))))..)).....)))..))))).))...........]]].)...))))))))))...)))))))(((((..((....))..)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((.(((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....)))).)))))).))).))).....((.....)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.((..(((((((..(((........(((((..((....))...)))))........))))))))..)))).(.(((......))).)........((.........(((((.......))))).)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((....]}.)))))..((((((((.(((.((......(.((.((((..(((((.(((.(((((.(((((((((((.(.((.(..........(((...(((.......(((((((....)))))))....))).............))).).)).).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((.....[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}.......)))..).)))......(.((.(.((((((...((.......))...))))))...).))..)....(.((.((((((..(((((((((......))))))..))).(((((....))))).....)))))..)...)).).....(.(((((....))).)))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((.(....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Escherichia coli transcription-translation coupled complex class B (TTC-B) containing RfaH bound to ops signal, NusA, mRNA with a 27 nt long spacer, and fMet-tRNAs in E-site and P-site of the ribosome; 23S rRNA 8uri d 120 5.3 RF00001 39117885 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. .(((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))).. Escherichia coli transcription-translation coupled complex class B (TTC-B) containing RfaH bound to ops signal, NusA, mRNA with a 27 nt long spacer, and fMet-tRNAs in E-site and P-site of the ribosome; 5S rRNA 8urx 7 33 6.6 39117885 32630 auguuuuuuuuuuuuuuuuuuuuuggugagagg ................................. ................................. Escherichia coli transcription-translation coupled complex class B (TTC-B) containing RfaH bound to ops signal, mRNA with a 30 nt long spacer, and fMet-tRNAs in E-site and P-site of the ribosome; mRNA with 30 nt long spacer 8urx A 76 6.6 RF00005 39117885 0030533 562 cgcgggguggagcagccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((........)))).(((((.......))))).....(((((.......)))))))))))..... Escherichia coli transcription-translation coupled complex class B (TTC-B) containing RfaH bound to ops signal, mRNA with a 30 nt long spacer, and fMet-tRNAs in E-site and P-site of the ribosome; E-site and P-site fMet-tRNA 8urx B 76 6.6 RF00005 39117885 0030533 562 cgcgggguggagcagccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((........)))).(((((.......))))).....(((((.......)))))))))))..... Escherichia coli transcription-translation coupled complex class B (TTC-B) containing RfaH bound to ops signal, mRNA with a 30 nt long spacer, and fMet-tRNAs in E-site and P-site of the ribosome; E-site and P-site fMet-tRNA 8urx D 1524 6.6 RF00177,RF01959,RF02542,RF01960 URS00000ABFE9_562 39117885 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccggccagcagcccgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgauaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgccguacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgaacaagguaaccguaggggccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<......>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>..<<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>>.<<<<<(((...<<<<<.......)))........>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<......>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<....<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>.>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>......<<..<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>....>>........<<<<<<<<<..>>>>>>>>>...... ........((((..[.[[[[.)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((........))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..........)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((((.......)))))))).....)....)))))....)..((((([[[...(((((....(..]]]).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))..]]]].](((((.(((((((.((..(((((..((((((((((......((......))..........(((((((..(...((.((((..(((.(((....))).))).............))))..))).((.(.(...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..(..((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))....)...)..)..(((((((((..)))))))))}..... Escherichia coli transcription-translation coupled complex class B (TTC-B) containing RfaH bound to ops signal, mRNA with a 30 nt long spacer, and fMet-tRNAs in E-site and P-site of the ribosome; 16S rRNA 8urx a 2880 6.6 RF02541 39117885 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaacccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcggggcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacgguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccucccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccgaacaaacgguccuaagguagcgaaauccuugucggguaaguuccgacugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugagaugcaguguacccgcggcaagacggaaagaccccguaaccuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgggauaacaggcgauaccgcccaagaguucauaucgacggcgguguuuggcacucggucggcucaucacauccuggggcugaaguaggucccaaggguauggcguucgccauuuaaagugguacgcgagcggguuuagaacgucgugagacagucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<.<....<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>..>>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>>.>>...............<<....>>....>>.........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<.....>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>>.>>...>>>>>>>.>...<<<<<<<<<.......>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....[[[...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<.....>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>.>......>>>>>>>>..>>>>..<<<<......>>>>.........<..........<<<<<<.....>>>>>>....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<.......>>>>>..<<<<<<<<.<<<.<<......<.<<..<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<..<<.......<<<<<<<<....>>>>>>>>....>>............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>..............>>>....>>>........<<...<<<<<<...<<.......>>...>>>>>>.....>>......<<.<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<....>>>>>.....>>>>>..>...>>.>>....<.<<<<<....>>>.>>>....>>..>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]].>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.....))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((.((.........))..))...)))).)))..)).).....))))))).))..)))))))).)...(((((((((.......)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{...((..(((..((((.......))))..))).....(..(((......))))..)).....)))..))))).))...........]]].)...))))))))))...)))))))(((((..((....))..)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((.(((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....)))).)))))).))).))).....((.....)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.((..(((((((..(((........(((((..((....))...)))))........))))))))..)))).(.(((......))).)........((.........(((((.......))))).)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((....]}.)))))..((((((((.(((.((......(.((.((((..(((((.(((.(((((.(((((((((((.(.((.(..........(((...(((.......(((((((....)))))))....))).............))).).)).).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((.....[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}.......)))..).)))......(.((.(.((((((...((.......))...))))))...).))..)....(.((.((((((..(((((((((......))))))..))).(((((....))))).....)))))..)...)).).....(.(((((....))).)))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((.(....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Escherichia coli transcription-translation coupled complex class B (TTC-B) containing RfaH bound to ops signal, mRNA with a 30 nt long spacer, and fMet-tRNAs in E-site and P-site of the ribosome; 23S rRNA 8urx d 120 6.6 RF00001 39117885 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. .(((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))).. Escherichia coli transcription-translation coupled complex class B (TTC-B) containing RfaH bound to ops signal, mRNA with a 30 nt long spacer, and fMet-tRNAs in E-site and P-site of the ribosome; 5S rRNA 8ury 7 37 3.1 39117885 32630 auguuuuuuuuuuuuuuuuuuuugauuuggugagagg ..................................... ..................................... Escherichia coli transcription-translation coupled complex class B (TTC-B) containing RfaH bound to ops signal, NusA, mRNA with a 30 nt long spacer, and fMet-tRNA in E-site and P-site of the ribosome; mRNA with 30 nt long spacer 8ury A 76 3.1 RF00005 39117885 0030533 562 cgcgggguggagcagccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((........)))).(((((.......))))).....(((((.......)))))))))))..... Escherichia coli transcription-translation coupled complex class B (TTC-B) containing RfaH bound to ops signal, NusA, mRNA with a 30 nt long spacer, and fMet-tRNA in E-site and P-site of the ribosome; E-site and P-site fMet-tRNA 8ury B 76 3.1 RF00005 39117885 0030533 562 cgcgggguggagcagccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((........)))).(((((.......))))).....(((((.......)))))))))))..... Escherichia coli transcription-translation coupled complex class B (TTC-B) containing RfaH bound to ops signal, NusA, mRNA with a 30 nt long spacer, and fMet-tRNA in E-site and P-site of the ribosome; E-site and P-site fMet-tRNA 8ury D 1524 3.1 RF00177,RF01959,RF02542,RF01960 URS00000ABFE9_562 39117885 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccggccagcagcccgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgauaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgccguacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgaacaagguaaccguaggggccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<......>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>..<<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>>.<<<<<(((...<<<<<.......)))........>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<......>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<....<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>.>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>......<<..<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>....>>........<<<<<<<<<..>>>>>>>>>...... ........((((..[.[[[[.)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((........))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..........)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((((.......)))))))).....)....)))))....)..((((([[[...(((((....(..]]]).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))..]]]].](((((.(((((((.((..(((((..((((((((((......((......))..........(((((((..(...((.((((..(((.(((....))).))).............))))..))).((.(.(...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..(..((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))....)...)..)..(((((((((..)))))))))}..... Escherichia coli transcription-translation coupled complex class B (TTC-B) containing RfaH bound to ops signal, NusA, mRNA with a 30 nt long spacer, and fMet-tRNA in E-site and P-site of the ribosome; 16S rRNA 8ury a 2880 3.1 RF02541 39117885 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaacccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcggggcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacgguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccucccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccgaacaaacgguccuaagguagcgaaauccuugucggguaaguuccgacugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugagaugcaguguacccgcggcaagacggaaagaccccguaaccuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgggauaacaggcgauaccgcccaagaguucauaucgacggcgguguuuggcacucggucggcucaucacauccuggggcugaaguaggucccaaggguauggcguucgccauuuaaagugguacgcgagcggguuuagaacgucgugagacagucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<.<....<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>..>>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>>.>>...............<<....>>....>>.........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<.....>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>>.>>...>>>>>>>.>...<<<<<<<<<.......>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....[[[...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<.....>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>.>......>>>>>>>>..>>>>..<<<<......>>>>.........<..........<<<<<<.....>>>>>>....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<.......>>>>>..<<<<<<<<.<<<.<<......<.<<..<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<..<<.......<<<<<<<<....>>>>>>>>....>>............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>..............>>>....>>>........<<...<<<<<<...<<.......>>...>>>>>>.....>>......<<.<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<....>>>>>.....>>>>>..>...>>.>>....<.<<<<<....>>>.>>>....>>..>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]].>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.....))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((.((.........))..))...)))).)))..)).).....))))))).))..)))))))).)...(((((((((.......)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{...((..(((..((((.......))))..))).....(..(((......))))..)).....)))..))))).))...........]]].)...))))))))))...)))))))(((((..((....))..)))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((.(((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....)))).)))))).))).))).....((.....)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.((..(((((((..(((........(((((..((....))...)))))........))))))))..)))).(.(((......))).)........((.........(((((.......))))).)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((....]}.)))))..((((((((.(((.((......(.((.((((..(((((.(((.(((((.(((((((((((.(.((.(..........(((...(((.......(((((((....)))))))....))).............))).).)).).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((.....[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}.......)))..).)))......(.((.(.((((((...((.......))...))))))...).))..)....(.((.((((((..(((((((((......))))))..))).(((((....))))).....)))))..)...)).).....(.(((((....))).)))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((.(....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Escherichia coli transcription-translation coupled complex class B (TTC-B) containing RfaH bound to ops signal, NusA, mRNA with a 30 nt long spacer, and fMet-tRNA in E-site and P-site of the ribosome; 23S rRNA 8ury d 120 3.1 RF00001 39117885 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. .(((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))).. Escherichia coli transcription-translation coupled complex class B (TTC-B) containing RfaH bound to ops signal, NusA, mRNA with a 30 nt long spacer, and fMet-tRNA in E-site and P-site of the ribosome; 5S rRNA 8ut0 2 1771 3.22 RF01960,RF02542,RF01959,RF00177 39900920 0003735 0005840 4932 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugagcuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauu ...<<<<<...((((>>>>><<<<.<<<<<<...<.<..........<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<..<<..<<....<<<..................<.....<<.<<.......>>.>>......>.........<<<<<..<<....>>..>>>>><...<<<<<<......[[.((((...............<<......>>>>>>>>.....>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>..>>>.......>.>.....<<<<<<<................>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>>.........<<<{{.....<.<<...<<<.<<....<<<<<<.<<<................>>>.>>>>>>.....<<<<<....................>>>>>....<<<<<.<<.......<<...<.......>..<<<<...>>>>....>>......>>.>>..>>>.........<<...<<<..<<<.....)))).]].>>>..>>>..>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>..>.>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..))))..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<.......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<<<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>...>.>>>>>>>.....>.>>>>>....>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<.<<<<.<<<<....>>>>.>>>>.>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>........ ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[...[[.(.(....).).....(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(((((((.(.(.(....).).).)))).)))....(.(((.(...........)).))......)..((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((................))).))))))......((((....................)))).....(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(....(.((.(((.....]]...]].))).)).)...).....))...(((.(((.((...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)).)))..))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].].((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((.....((((((.(..(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..))))).)..))).))).......))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).)...(.(..((.(..((((.((..(.((((((((.(((..(.((..(...(((((((.((((.((((....)))).)))).)))))))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>....... Eukaryotic 80S ribosome with Reh1, eIF5A and A/P site tRNA; 18S rRNA 8ut0 A 3184 3.22 RF02540,RF02541,RF02543 39900920 0003735 0005840 4932 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaugguguuuuguauuucacuggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauagagggcuaccuuuauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>...{.....<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<<.<<<<<<<<<<<<<<<<<<<<.....<<<<......>>>>.(.......<<<......)>>>....>>>>>>>>>..>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]....}.............................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<.......<<............>>..<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<....<<.<<<<<<<.....<<<....<<<....<<<<....<<<<<.....>>>>>..>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>..>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<......<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>....>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>>..<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<...<...>....>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<<....<<<....>>>.......<<<<<<...<<<<.<<<<<<<<<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<<....>>>>>>>>>>>>.>.>>>>>>>.>>>>.........>>>>>>.........>>.>>.>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<.<<<<<<<<<<<....>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.....<<....<<<<<....>>>>.>...>>..>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<<<<<<<<<....>>>>>>>.>>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<...<<<<<<<<<<<}}}.>>>>>..>>>>>>..>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<.<..<<<<<......>>>>>..>>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((..((((((..((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))..))....)))).))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((......(..............)..(((((((((((((((((.(((((.......(((((((......((((((....)))))).......))))))).....)))))..)))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).(((.((((....(....)....))).).).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((....((.(((((((.....(((....(((..(.((((....(((((.....)))))..)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((.(((...................))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........((((..((...))...))))....))....))...(((((........)))))]]((((..(((((.(...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....)..)).))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.((((((((((.(...)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((.(((((..(((((((((((((((((....))))))).))))))))))....((((.....((((..((((........))))...........>...((((((....))))))..))))..))))......))))).))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....))))))))......(((((((.(((.((....((.(........(((((((..).)))))).....))).......((.(((...(((((.(..(((......)))..).))))).))).)).............)).))).)))))).)(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Eukaryotic 80S ribosome with Reh1, eIF5A and A/P site tRNA; 25S rRNA 8ut0 B 121 3.22 RF00001 39900920 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<<............>>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Eukaryotic 80S ribosome with Reh1, eIF5A and A/P site tRNA; 5S rRNA 8ut0 C 158 3.22 RF00002 39900920 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Eukaryotic 80S ribosome with Reh1, eIF5A and A/P site tRNA; 5.8S rRNA 8ut0 m 76 3.22 RF00005 39900920 0030533 4932 gggucguuagcucaguugguagagcaguugacuuuuaaucaauuggucgcagguucgaauccugcacgacccacca <<<<<<<..<<<<........>>>><<<<<<.......>>>>>>....<<.............>>>>>>>>>.... (((((((..((((........))))(.((((.......)))).)....(.(.(.......).).)))))))).... Eukaryotic 80S ribosome with Reh1, eIF5A and A/P site tRNA; A site tRNA 8ut0 n 75 3.22 RF00005 URS00021ED942_559292 39900920 0030533 0006412 4932 agcgccgugacgcaguggaagcgcgcagggcucauaacccugauguccucggaucgaaaccgagcggcgcuacca <<<<<<<...<<<.......>>>.<<<<<<.......>>>>>.>...<<<<<.......>>>>>>>>>>>>.... (((((((...(((....[..)))..(((((.......))))).....(((((..]....)))))))))))).... Eukaryotic 80S ribosome with Reh1, eIF5A and A/P site tRNA; P site initiator tRNA 8ut0 D 10 3.22 39900920 4932 aauaugaaaa .......... .......... Eukaryotic 80S ribosome with Reh1, eIF5A and A/P site tRNA; Messenger RNA (5'-R(P*AP*AP*UP*AP*UP*GP*AP*AP*AP*A)-3') 8uti A 3044 3.13 RF02540,RF02541,RF02543 39900920 0003735 0005840 4932 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacauuggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcagcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagcuuuacuuauucaaugaagcggagcuggaauuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>...<.....<<....>>..<<<<<......<<.....>>.....>>>>>..<<<..<........<<.<<<<<<...>>>>>>.>>........>....<<<<<<.<<<<<<<<<<<<<<<<<.....<<<<......>>>>.(.......<<<......)>>>....>>>>>>>>>..>>>.>>>>>>>>>>>........<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>....>.............................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<........<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<..<<<<<.....>>>>>..>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<....<....>....>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<....<<.<<<<<<<.....<<<....<<<....<<<..>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>..>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<......<..........<<<.<<<<<<<<<<.......<<<<..>>>>...>>>>>>>>>>>>>..........))).>....>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>>..<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<.......>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<<....<<<....>>>.......<<<<<<...<<<<.<<<<<<<<<<<<<<<<<<..[[[..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<.>>>>>>>>>>>.>.>>>>>>>.>>>>.........>>>>>>.........>>.>>.>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<.<<<<<<<<<<<....>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.....<<.....<<<<....>>>>.....>>..>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<..<<<<<..>>>>>...<<<<<.....<<<<..<<<<..>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))......<<<<<<<..<<<<.))))))>>>>>>>>>>>.........>>>>..>>>>>>.......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<...<<<<<<<<<<<]]].>>>>>..>>>>>>..>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<.<..<<<<<......>>>>>..>>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.((((((((.((((((((...({((((......)))))[[(...).(((....}]])))....))))))))...))).)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.......(((((((((((((((((((((((.......(((((((......((((((....)))))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).[((((........))))((((((....((((((.((((((..(((..((((.......))))..)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((....((.(((((((.....(((....(((..(.(((()))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.((((()))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...((((((...((.....)).))))))....[[(((.((...((....(((....)))........((((.......))))....))....))...(((((........)))))]]((((..(((.(((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((.))))))))))).).))))))).))))(...)....))))))...))....)).)..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((....)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((.(((((..(((((())))))....((((.....((((..((((..))))...........>...((((((....))))))..))))..))))......))))).))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..(((..(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...))))..)))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(((.((..)..).)))..)))))...)))....)))).)))))).))))).. Eukaryotic 80S ribosome with Reh1 and A/P site tRNA; 25S rRNA 8uti B 121 3.13 RF00001 39900920 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<<............>>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Eukaryotic 80S ribosome with Reh1 and A/P site tRNA; 5S rRNA 8uti C 158 3.13 RF00002 39900920 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Eukaryotic 80S ribosome with Reh1 and A/P site tRNA; 5.8S rRNA 8uti D 10 3.13 39900920 4932 aauaugaaaa .......... .......... Eukaryotic 80S ribosome with Reh1 and A/P site tRNA; Messenger RNA (5'-R(P*AP*AP*UP*AP*AP*UP*GP*AP*AP*AP*A)-3') 8uti m 76 3.13 RF00005 39900920 0030533 4932 gggucguuagcucaguugguagagcaguugacuuuuaaucaauuggucgcagguucgaauccugcacgacccacca <<<<<<<..<<<<........>>>><<<<<<.......>>>>>>....<<<...........>>>>>>>>>>.... (((((((..((((........))))((((((.......))))))....(((...........)))))))))).... Eukaryotic 80S ribosome with Reh1 and A/P site tRNA; A site tRNA 8uti n 75 3.13 RF00005 URS00002CB170_4932 39900920 0030533 0006412 4932 agcgccguggcgcaguggaagcgcgcagggcucauaacccugauguccucggaucgaaaccgagcggcgcuacca <<<<<<<..<<<<.......>>>><<<<<<.......>>>>>.>...<<<<<.......>>>>>>>>>>>>.... (((((((..((((....[..)))).(((((.......))))).....(((((..]....)))))))))))).... Eukaryotic 80S ribosome with Reh1 and A/P site tRNA; P site initiator tRNA 8uti E 1597 3.13 RF01960,RF02542,RF01959,RF00177 39900920 0003735 0005840 4932 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaauuguauuuauuaggaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuacggggccuuuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauu ...<<<<<.[.((((>>>>><<<<.<<<<<<...<.<...<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<..<<..<<....<<<..................<.....<<.<<.......>>.>>......>............<.<.<<<<<<.<......>.>>>>>>.>...>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>..>>>..>....>.>.....<<..>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>>.........<<<((.....<.<<...<<<.<<....<<<<<<.<<.>>.>>>>>>...<<<<<.<<.......<<...<.......>..<<<<...>>>>....>>......>>.>>..>>>.........<<<..<<<<<<<..>>>>>>>.>>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>......<<<....>>>..>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<..>>>>>>>>>>>..>>>...<<..))>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>......<....<<<<<<..........>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<..>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>........ ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...))[))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....))............(.(.((((((.(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)....).).....((..))....(.(((.(...........)).))......)..((((([[....(.((((.....((..]])).......))))))))))..))))))))))..[......((([[...(.(.((...(((.((....((((((.((.)).))))))...((((..((.......((..((.......)).(((.....)))....))......))..)..))).........(....(.((.((())).)).)...).....))...(((..((..(...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)..))...))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..((((((((.(((..)))))))))))..)))...((..]]))...))...].))))))).(((......((((....))))....)))...]]].].((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((.....((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).......))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).)...(.(..((.(..((((.((..(.((((((((.(((..(.((..(...(((())))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}....... Eukaryotic 80S ribosome with Reh1 and A/P site tRNA; 18S rRNA 8uu4 a 1516 3.0 RF01959,RF00177,RF02542,RF01960 38407413 0003735 0005840 1642 aaagagaguuugauccuggcucaggacgaacgcuggcggcgugccuaauacaugcaagucgaacgaacggaaguuaguggcggacgggugaguaacacgugggcaaccugccuguaaguuggggauaacuccgggaaaccggggcuaauaccgaaugauagaguguggcgcaugccacgcucuugaaagaugguuucggcuaucgcuuacagaugggcccgcggugcauuagcuaguugguaggguaauggccuaccaaggcaacgaugcauagccgaccugagagggugaucggccacacugggacugagacacggcccagacuccuacgggaggcagcaguagggaaucuuccgcaauggacgaaagucugacggagcaacgccgcguguaugaagaagguuuucggaucguaaaguacuguuguuagagaagaacaaggauaagaguaacugcuugucccuugacgguaucuaaccagaaagccacggcuaacuacgugccagcagccgcgguaauacguagguggcaagcguuguccggauuuauugggcguaaagcgcgcgcaggcggucuuuuaagucugaugugaaagcccccggcuuaaccggggagggucauuggaaacuggaagacuggagugcagaagaggagaguggaauuccacguguagcggugaaaugcguagauauguggaggaacaccaguggcgaaggcgacucucuggucuguaacugacgcugaggcgcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugagugcuaaguguuaggggguuuccgccccuuagugcugcagcuaacgcauuaagcacuccgccuggggaguacgaccgcaagguugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggucuugacauccuuugaccacucuggagacagagcuuucccgggacaaagugacagguggugcaugguugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuugauuuuaguugccagcauuuaguugggcacucuaaagugacugccggugcaagccggaggaagguggggaugacgucaaaucaucaugccccuuaugaccugggcuacacacgugcuacaauggaugguacaaagggucgcgaagccgcgagguggagccaaucccauaaaaccauucucaguucggauuguaggcugcaacucgccuacaugaagccggaaucgcuaguaaucguggaucagcaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccacgagaguuuguaacacccgaagucgguaggguaaccggagccagccgccgaaggugggacagauaauuggggugaagucguaacaagguagccguaucggaaggugcggcuggaucaccuccu .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<<....>>>.>>>>>......<<........<<<<<<<..<<...<<<<<<<<<.<<.....<<<<<<....>>>>>>......>>.>.....<<<<<<<<<<....>>>>>>>>>>.....<<<<<<....>>>>>>>>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<<<<<<<.......<.<<<<<<<........>>>>>>>.>........>>>>>>...>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<.......<<<<<<.....>>>>>>.....>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<<..<<<......>>>.....>>>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<<....>>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<....<<<<<....>>>>>....<<..>>.>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<......>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<..<<<<....<.<<<<..<<<..<<>>.>>>.>>>>.>...>>>>..>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .....((((..[.[[[..)))).((((.((((...(((((((((....(((.(((..(((..((.(((....))).)))))......(((.......(((((((..((...(((((((((.((.....((((((....))))))......)).).....((((.(((((....))))).)))).....((((((....))))))))))))))..))))))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..(.((......((((....)))).....)).)....((((((...(.....(((.(((........))).))).....)....))))))......((((([[[...(((((.....((.]]])).......))))))))))...))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))...).)))))))..)))))))))..(((((((((...((((((((....(((((.(...((........))......).)))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((......))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((....(((((....)))))....((())).))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..((......)))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....))))))))..)).)))))))).(...(((((((.....(((..((....((....))....))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((..((((....(.((((..(((..(()).))).)))).)...))))..))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Cryo-EM structure of the Listeria innocua 70S ribosome in complex with HPF (structure I-A); 16S Ribosomal RNA 8uu4 A 2903 3.0 RF02541 38407413 0003735 0005840 1642 uuaaguuagaaagggcgcacgguggaugccuuggcacuaggagccgaagaaggacgggacuaacaccgauaugcuuuggggagcuguacguaagcguugauccagagauuuccgaaugggggaacccacuaucuuuagucggauaguauccuuacgugaauacauagcgugaggaaggcagacccagggaacugaaacaucuaaguaccuggaggaagagaaagaaaaaucgauuuccugaguagcggcgagcgaaacggaaagagcccaaaccaagaagcuugcuucuugggguuguaggacacucuauacggaguuacaaaagaaaguuauaaaugaagcggucuggaaaggcccgccaaagacgguaacagcccgguaguugaaauggcuuucccuccagaguggauccugaguacgacggaacacgugaaauuccgucggaauccgggaggaccaucucccaaggcuaaauacucccuagugaccgauagugaaccaguaccgugagggaaaggugaaaagcaccccggaaggggagugaaacaguuccugaaaccgugugccuacaaguaguuagagcccguuaaugggugauagcgugccuuuuguagaaugaaccggcgaguuacgauuuguugcaagguuaagcggaaaaagcggagccguagcgaaagcgagucugaauagggcgcauaaguaacaggucguagacccgaaaccaggugaucuacccauguccaggaugaagguaagguaauacuuacuggagguccgaacccacgcacguugaaaagugcggggaugagguguggguagcggagaaauuccaaucgaacuuggagauagcugguucucuccgaaauagcuuuagggcuagccucgagguaaagagucauggagguagagcacuguuuggacuaggggcccgguuaccgaauucagauaaacuccgaaugccauguacuuauacucgggagucagacugcgagugauaagauccguagucgaaagggaaacagcccagaccaccaguuaagguccccaaauauauguuaaguggaaaaggaugugggguugcuuagacaaccaggauguuggcuuagaagcagccaccauugaaagagugcguaauagcucacuggucgagugaccccgcgccgaaaauguaccggggcuaaacauauuaccgaaacuguggaugaaccgguucgugguaggagagcguucuaagggcggugaagucagaccggaaggacugguggagcgcuuagaagugagaaugccgguaugaguagcgaaagaagggugagaaucccuuccaccgaauaucuaagguuuccugaggaaggcucguccgcucaggguuagucgggaccuaagccgaggccgauaggcguaggcgauggacaacagguagagauuccuguaccagugcuaauuguuuaaccgauggggugacacagaaggauagggaaucgcacgaauggaaaugugcguccaagcagugagugugagaaguaggcaaauccgcuucuugcgaagcaugagcugugauggggaagcggaaguuccugauuucacgcugucaagaaaagccucuaggaagaguaguacugcccguaccgcaaaccgacacagguagaugaggagagaauccuaaggugagcgagagaacucucguuaaggaacucggcaaaaugaccccguaacuucgggagaaggggugcucuauuagggugcaagcccgagagagccgcagugaauaggcccaggcgacuguuuagcaaaaacacaggucucugcaaaaccguaaggugacguauaggggcugacgccugcccggugcuggaagguuaagaggagugcuuagcuucggcgaagguacgaauugaagccccaguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgacccgcacgaaaggcgcaacgaucugggcacugucucaacgagagacucggugaaauuauaguaccugugaagaugcagguuacccgcgacaggacggaaagaccccguggagcuuuacugcaaccugauauggaauguuuguaccgcuuguacaggauagguaggagccgaagagacgugugcgcuagcauacgaggaggcaauggugggauacuacccuggcuguaugaccauucuaacccgccacgcuaagcgcguggggagacagugucaggugggcaguuugacuggggcggucgccuccuaaagaguaacggaggcgcccaaagguucccucagaauggauggaaaucauucgcagaguguaaaggcacaagggagcuugacugcgagacugacaagucgagcagggacgaaagucgggcuuagugauccggugguuccgcauggaagggccaucgcucaacggauaaaagcuaccccggggauaacaggcuuaucucccccaagaguccacaucgacggggagguuuggcaccucgaugucggcucgucgcauccuggggcuguagucggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucccuauccgucgcgggcgcaggaaauuugagaggagcuguccuuaguacgagaggaccgggauggacacaccgcugguguaccaguuguuccgccaggagcaucgcuggguagcuauguguggcagggauaaacgcugaaagcaucuaagcgugaagccccccucaagaugagauuucccauuucuucggaaaguaagaucccugaaagaugaucagguagauagguuuggaguggaaguguagcgauacauggagcggacaaauacuaaucgaucgaggacuuaacc <<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>....<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..(((....<<<<<<<<....>>>>>>>>......<<<<<<<<<<....<<<<........<<<<<<<<<.<<<.....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>.>>>>>>>>>>..>>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<......>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.......>>...>>>...<<....>>..<<<<.....>>>>......>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<.....<<<<<<<<<.....<<<...<<<<<<<<...<<.<<<.>>>..>>...>>>>>>>>..>>.>.....>>>>>.>>>>...>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>...>>>>>>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<..>>>>>>....>>>>>><.<<<<<<<.<<......<<<<<.<<....>>.>>>>>...>>.>>>>>>>..>.....>>>>>><......<<....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<.<<......<<...<<<<<...<<<<..<<<..<<<<<.<<<<<...(((....>>>>>.<<..<<<<<..<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>..>>>>>...>>...........>>>>>...>>>...>>>>........>>>>>..>>..>>.>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<....<<<<....>>>>...>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>..<<<<.<<<..<<<<<<<..<<<<..<<...<<<<<<.<<<..>>>..>>>>>>...>>..>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>...>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<<.<<<<<..<<<<<.<<<...........<<<<<..<<<.......<<<<<<<....>>>>>>>....>>>............>>>>>..>>>.>>>>>..>>>>>....<<.<<<<<<.....>>>>>>>>.....>>>>>>>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<.<......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.)))>>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<<..>>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>...>>>>....>>>>>>.. ((((((......((((((((((.....(((..(((((((((((((......((((((.[[..[[[)))...].((((((...(((]]..]].)))......))))))...)))....(((....)))(((((((......))))))).(((((((((.........))))))))).))....((((((.....(...[..)......))))).).........((....))...((((......((.]...)).....))))...((((...(((((((((..)))))))))....{.((((((((((....((((........(((((((((.(((...(.((((......)))))[[(...).(((.....]])))...)))...))))))))).))))))))))..)))))....((((((((..[......))))))))....}.(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((..((((..[...))))..)))).<.(.(........).).((((((....(((((((((((((..(((...((.......))...)))...((....))..((((.....))))......)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)<)))...(((.(((((.......A))))))))..).))))))))).(.(((....[)))...).]))))))......).))..((((((....(((((....)))))((((((((....((((((((((.....(((...((((((((...((..((.))...))...))))))))..)).).....))))).)))).).)))))).))..(((((((.((......)).)))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((..(((.........)))..))).....(...((......)).).)))))...)))))))))).))...........]]].)...))))))))))...)))))))((((((()))))))....))))))(.(((((((.((......(((((.((....))])))))...)).)))))))..).....))))))(......((....((((((.......))))))((((....(((...((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]]((((((((.((......((...(((((...((((..(((..(((((.(((((....{{....))))).((..(((((..((((.((((((.((.....))))))))......))))..)))))...))...........)))))...)))...))))(..)....)))))..))..)).)))))))))))).))).....((......))..))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))(((((....((((....))))...)))))(...).......(((((((((.>.((.........))...(((((((.....(((....)))..[....))))))).}((((.(((..(((((((..(((...((...(((((..((....))...)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).[..(((((.....>].)))))..((((((((.(((.((......((((.((((((..(((((.(((((((((.(((((..(.(((.(((.(......[..(((((..(((.......(((((((....)))))))....)))..........].)))))).))).)))..).)))))....((.((((((...].)))))))).....)))))))))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.(......))))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))..a.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((....))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...))))))).. Cryo-EM structure of the Listeria innocua 70S ribosome in complex with HPF (structure I-A); 23S Ribosomal RNA 8uu4 B 114 3.0 RF00001 URS0002311A24_169963 38407413 0003735 0005840 1642 cugguaguuauggcgagaaggucacacccguucccaucccgaacacgguaguuaagcuucucugcgccaaugguaguugggggcuucccccugcgagaguaggucgcugccggg <<<<<<<<....<<<<<<<<.....<<<<<<.............>>>>..>>....>>>>>>.>><<<.......<<.<<<<<...>>>>>.>>.......>>>.>>>>>>>>. ((((((((....((((((((.....((((((...(.....)...))))..))....)))))).))(((.......((.(((((...))))).)).......))).)))))))). Cryo-EM structure of the Listeria innocua 70S ribosome in complex with HPF (structure I-A); 5S Ribosomal RNA 8uu5 a 1523 3.0 RF01959,RF00177,RF02542,RF01960 38407413 0003735 0005840 1642 aaagagaguuugauccuggcucaggacgaacgcuggcggcgugccuaauacaugcaagucgaacgaacggagguccaaaguuaguggcggacgggugaguaacacgugggcaaccugccuguaaguuggggauaacuccgggaaaccggggcuaauaccgaaugauagaguguggcgcaugccacgcucuugaaagaugguuucggcuaucgcuuacagaugggcccgcggugcauuagcuaguugguaggguaauggccuaccaaggcaacgaugcauagccgaccugagagggugaucggccacacugggacugagacacggcccagacuccuacgggaggcagcaguagggaaucuuccgcaauggacgaaagucugacggagcaacgccgcguguaugaagaagguuuucggaucguaaaguacuguuguuagagaagaacaaggauaagaguaacugcuugucccuugacgguaucuaaccagaaagccacggcuaacuacgugccagcagccgcgguaauacguagguggcaagcguuguccggauuuauugggcguaaagcgcgcgcaggcggucuuuuaagucugaugugaaagcccccggcuuaaccggggagggucauuggaaacuggaagacuggagugcagaagaggagaguggaauuccacguguagcggugaaaugcguagauauguggaggaacaccaguggcgaaggcgacucucuggucuguaacugacgcugaggcgcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugagugcuaaguguuaggggguuuccgccccuuagugcugcagcuaacgcauuaagcacuccgccuggggaguacgaccgcaagguugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggucuugacauccuuugaccacucuggagacagagcuuucccgggacaaagugacagguggugcaugguugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuugauuuuaguugccagcauuuaguugggcacucuaaagugacugccggugcaagccggaggaagguggggaugacgucaaaucaucaugccccuuaugaccugggcuacacacgugcuacaauggaugguacaaagggucgcgaagccgcgagguggagccaaucccauaaaaccauucucaguucggauuguaggcugcaacucgccuacaugaagccggaaucgcuaguaaucguggaucagcaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccacgagaguuuguaacacccgaagucgguaggguaaccggagccagccgccgaaggugggacagauaauuggggugaagucguaacaagguagccguaucggaaggugcggcuggaucaccuccu .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<..<<...<...>...>>..>>>>>......<<........<<<<<<<..<<...<<<<<<<<<.<<.....<<<<<<....>>>>>>......>>.>.....<<<<<<<<<<....>>>>>>>>>>.....<<<<<<....>>>>>>>>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<<<<<<<.......<.<<<<<<<........>>>>>>>.>........>>>>>>...>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<.......<<<<<<.....>>>>>>.....>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<<..<<<......>>>.....>>>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<<....>>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<.....<<<<<....>>>>>....<<<>>>..>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<......>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<..<<<<....<.<<<<..<<<..<<>>.>>>.>>>>.>...>>>>..>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((...(...((.))...)...)))))......(((.......(((((((..((...(((((((((.((.....((((((....))))))......)).).....((((.(((((....))))).)))).....(((((......)))))))))))))..))))))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(((((((...(.....(((.(((........))).))).....)....))))))...)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))...).)))))))..)))))))))..((((.((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))))..)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((......))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].].((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((.((((....(((((....)))))....((())).))))..))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..((......)))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...((((((......(((..((...(((....)))...))....)))......))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).)...(.(..((.(.((((.(((..((((((..((((....(.((((..(((..(()).))).)))).)...))))..))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Cryo-EM structure of the Listeria innocua 70S ribosome (head-swiveled) in complex with pe/E-tRNA (structure I-B); 16S Ribosomal RNA 8uu5 x 74 3.0 RF00005 38407413 0030533 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[..)))).((((.........)))).....((.((..]....)).))))))))).... Cryo-EM structure of the Listeria innocua 70S ribosome (head-swiveled) in complex with pe/E-tRNA (structure I-B); pe/E Hybrid State Phenylalanine tRNA 8uu5 w 14 3.0 38407413 2681598 ggaggaaaaauucu .............. .............. Cryo-EM structure of the Listeria innocua 70S ribosome (head-swiveled) in complex with pe/E-tRNA (structure I-B); F-Stop mRNA 8uu5 A 2902 3.0 RF02541 38407413 0003735 0005840 1642 uuaaguuagaaagggcgcacgguggaugccuuggcacuaggagccgaagaaggacgggacuaacaccgauaugcuuuggggagcuguacguaagcguugauccagagauuuccgaaugggggaacccacuaucuuuagucggauaguauccuuacgugaauacauagcgugaggaaggcagacccagggaacugaaacaucuaaguaccuggaggaagagaaagaaaaaucgauuuccugaguagcggcgagcgaaacggaaagagcccaaaccaagaagcuugcuucuugggguuguaggacacucuauacggaguuacaaaagaaaguuauaaaugaagcggucuggaaaggcccgccaaagacgguaacagcccgguaguugaaauggcuuucccuccagaguggauccugaguacgacggaacacgugaaauuccgucggaauccgggaggaccaucucccaaggcuaaauacucccuagugaccgauagugaaccaguaccgugagggaaaggugaaaagcaccccggaaggggagugaaacaguuccugaaaccgugugccuacaaguaguuagagcccguuaaugggugauagcgugccuuuuguagaaugaaccggcgaguuacgauuuguugcaagguuaagcggaaaaagcggagccguagcgaaagcgagucugaauagggcgcauaaguaacaggucguagacccgaaaccaggugaucuacccauguccaggaugaagguaagguaauacuuacuggagguccgaacccacgcacguugaaaagugcggggaugagguguggguagcggagaaauuccaaucgaacuuggagauagcugguucucuccgaaauagcuuuagggcuagccucgagguaaagagucauggagguagagcacuguuuggacuaggggccgguuaccgaauucagauaaacuccgaaugccauguacuuauacucgggagucagacugcgagugauaagauccguagucgaaagggaaacagcccagaccaccaguuaagguccccaaauauauguuaaguggaaaaggaugugggguugcuuagacaaccaggauguuggcuuagaagcagccaccauugaaagagugcguaauagcucacuggucgagugaccccgcgccgaaaauguaccggggcuaaacauauuaccgaaacuguggaugaaccgguucgugguaggagagcguucuaagggcggugaagucagaccggaaggacugguggagcgcuuagaagugagaaugccgguaugaguagcgaaagaagggugagaaucccuuccaccgaauaucuaagguuuccugaggaaggcucguccgcucaggguuagucgggaccuaagccgaggccgauaggcguaggcgauggacaacagguagagauuccuguaccagugcuaauuguuuaaccgauggggugacacagaaggauagggaaucgcacgaauggaaaugugcguccaagcagugagugugagaaguaggcaaauccgcuucuugcgaagcaugagcugugauggggaagcggaaguuccugauuucacgcugucaagaaaagccucuaggaagaguaguacugcccguaccgcaaaccgacacagguagaugaggagagaauccuaaggugagcgagagaacucucguuaaggaacucggcaaaaugaccccguaacuucgggagaaggggugcucuauuagggugcaagcccgagagagccgcagugaauaggcccaggcgacuguuuagcaaaaacacaggucucugcaaaaccguaaggugacguauaggggcugacgccugcccggugcuggaagguuaagaggagugcuuagcuucggcgaagguacgaauugaagccccaguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgacccgcacgaaaggcgcaacgaucugggcacugucucaacgagagacucggugaaauuauaguaccugugaagaugcagguuacccgcgacaggacggaaagaccccguggagcuuuacugcaaccugauauggaauguuuguaccgcuuguacaggauagguaggagccgaagagacgugugcgcuagcauacgaggaggcaauggugggauacuacccuggcuguaugaccauucuaacccgccacgcuaagcgcguggggagacagugucaggugggcaguuugacuggggcggucgccuccuaaagaguaacggaggcgcccaaagguucccucagaauggauggaaaucauucgcagaguguaaaggcacaagggagcuugacugcgagacugacaagucgagcagggacgaaagucgggcuuagugauccggugguuccgcauggaagggccaucgcucaacggauaaaagcuaccccggggauaacaggcuuaucucccccaagaguccacaucgacggggagguuuggcaccucgaugucggcucgucgcauccuggggcuguagucggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucccuauccgucgcgggcgcaggaaauuugagaggagcuguccuuaguacgagaggaccgggauggacacaccgcugguguaccaguuguuccgccaggagcaucgcuggguagcuauguguggcagggauaaacgcugaaagcaucuaagcgugaagccccccucaagaugagauuucccauuucuucggaaaguaagaucccugaaagaugaucagguagauagguuuggaguggaaguguagcgauacauggagcggacaaauacuaaucgaucgaggacuuaacc <<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>....<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..(((....<<<<<<<<....>>>>>>>>......<<<<<<<<<<....<<<<........<<<<<<<<<.<<<.....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>.>>>>>>>>>>..>>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<......>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.......>>...>>>...<<....>>..<<<<.....>>>>......>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<.....<<<<<<<<<.....<<<...<<<<<<<<......<<..>>.......>>>>>>>>..>>.>.....>>>>>.>>>>...>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<.<......<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>..>.>>>>>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<..>>>>>>....>>>>>><.<<<<<<<.<<......<<<<<.<<....>>.>>>>>...>>.>>>>>>>..>.....>>>>>><......<<....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<.<<......<<...<<<<<...<<<<..<<<..<<<<<.<<<<<...(((....>>>>>.<<..<<<<<..<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>..>>>>>...>>...........>>>>>...>>>...>>>>........>>>>>..>>..>>.>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<....<<<<....>>>>...>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>..<<<<.<<<..<<<<<<<..<<<<..<<...<<<<<<.<<....>>..>>>>>>...>>..>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>...>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<<.<<<<<.<<<<<<.<<<...........<<<<<..<<<.......<<<<<<<....>>>>>>>....>>>............>>>>>..>>>.>>>>>>.>>>>>....<<.<<<<<<.....>>>>>>>>.....>>>>>>>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.)))>>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>...>>>>....>>>>>>.. 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Cryo-EM structure of the Listeria innocua 70S ribosome (head-swiveled) in complex with pe/E-tRNA (structure I-B); 23S Ribosomal RNA 8uu5 B 114 3.0 RF00001 URS0002311A24_169963 38407413 0003735 0005840 1642 cugguaguuauggcgagaaggucacacccguucccaucccgaacacgguaguuaagcuucucugcgccaaugguaguugggggcuucccccugcgagaguaggucgcugccggg <<<<<<<<....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>><<<.......<<.<<<<<...>>>>>.>>.......>>>.>>>>>>>>. ((((((((....((((((((.....((((((...(.....)...))))..))....)))))).))(((.......((.(((((...))))).)).......))).)))))))). Cryo-EM structure of the Listeria innocua 70S ribosome (head-swiveled) in complex with pe/E-tRNA (structure I-B); 5S Ribosomal RNA 8uu6 a 1516 3.3 RF01959,RF00177,RF02542,RF01960 38407413 0003735 0005840 1642 aaagagaguuugauccuggcucaggacgaacgcuggcggcgugccuaauacaugcaagucgaacgaacggaaguuaguggcggacgggugaguaacacgugggcaaccugccuguaaguuggggauaacuccgggaaaccggggcuaauaccgaaugauagaguguggcgcaugccacgcucuugaaagaugguuucggcuaucgcuuacagaugggcccgcggugcauuagcuaguugguaggguaauggccuaccaaggcaacgaugcauagccgaccugagagggugaucggccacacugggacugagacacggcccagacuccuacgggaggcagcaguagggaaucuuccgcaauggacgaaagucugacggagcaacgccgcguguaugaagaagguuuucggaucguaaaguacuguuguuagagaagaacaaggauaagaguaacugcuugucccuugacgguaucuaaccagaaagccacggcuaacuacgugccagcagccgcgguaauacguagguggcaagcguuguccggauuuauugggcguaaagcgcgcgcaggcggucuuuuaagucugaugugaaagcccccggcuuaaccggggagggucauuggaaacuggaagacuggagugcagaagaggagaguggaauuccacguguagcggugaaaugcguagauauguggaggaacaccaguggcgaaggcgacucucuggucuguaacugacgcugaggcgcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugagugcuaaguguuaggggguuuccgccccuuagugcugcagcuaacgcauuaagcacuccgccuggggaguacgaccgcaagguugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggucuugacauccuuugaccacucuggagacagagcuuucccgggacaaagugacagguggugcaugguugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuugauuuuaguugccagcauuuaguugggcacucuaaagugacugccggugcaagccggaggaagguggggaugacgucaaaucaucaugccccuuaugaccugggcuacacacgugcuacaauggaugguacaaagggucgcgaagccgcgagguggagccaaucccauaaaaccauucucaguucggauuguaggcugcaacucgccuacaugaagccggaaucgcuaguaaucguggaucagcaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccacgagaguuuguaacacccgaagucgguaggguaaccggagccagccgccgaaggugggacagauaauuggggugaagucguaacaagguagccguaucggaaggugcggcuggaucaccuccu .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..................>>>......<<........<<<<<<<..<<...<<<<<<<<<.<<.....<<<<<<....>>>>>>......>>.>.....<<<<<<<<<<....>>>>>>>>>>.....<<<<<<....>>>>>>>>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<<<<<<<.......<.<<<<<<<........>>>>>>>.>........>>>>>>...>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<.......<<<<<<.....>>>>>>.....>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<<..<<<......>>>.....>>>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<<....>>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<....<<<<<....>>>>>....<<<>>>.>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>...<<<......>>>...>>>>>>.....<<<<.<<<<<<<..<<<..<<......>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<..<<<<....<.<<<<..<<<..<<>>.>>>.>>>>.>...>>>>..>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..................)))......(((.......(((((((..((...(((((((((.((.....((((((....))))))......)).).....((((.(((((....))))).)))).....(((((......)))))))))))))..))))))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....((((((...(.....(((((((........))))))).....)....))))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.((((((..((((((((((......((((((.....))))))...).)))))))..)).))))))..(((((((((...((((((((....(((((.(...((........))......).)))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((((((....)))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((.((((....(((((....)))))....((())).))))..))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..((......)))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...((((((......(((..((...(((....)))...))....)))......))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((..((((....(.((((..(((..(()).))).)))).)...))))..))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Cryo-EM structure of the ratcheted Listeria innocua 70S ribosome in complex with p/E-tRNA (structure II-A); 16S Ribosomal RNA 8uu6 x 74 3.3 RF00005 38407413 0030533 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[..)))).((((.........)))).....((.((..]....)).))))))))).... Cryo-EM structure of the ratcheted Listeria innocua 70S ribosome in complex with p/E-tRNA (structure II-A); p/E Hybrid State Phenylalanine tRNA 8uu6 A 2904 3.3 RF02541 38407413 0003735 0005840 1642 guuaaguuagaaagggcgcacgguggaugccuuggcacuaggagccgaagaaggacgggacuaacaccgauaugcuuuggggagcuguacguaagcguugauccagagauuuccgaaugggggaacccacuaucuuuagucggauaguauccuuacgugaauacauagcgugaggaaggcagacccagggaacugaaacaucuaaguaccuggaggaagagaaagaaaaaucgauuuccugaguagcggcgagcgaaacggaaagagcccaaaccaagaagcuugcuucuugggguuguaggacacucuauacggaguuacaaaagaaaguuauaaaugaagcggucuggaaaggcccgccaaagacgguaacagcccgguaguugaaauggcuuucccuccagaguggauccugaguacgacggaacacgugaaauuccgucggaauccgggaggaccaucucccaaggcuaaauacucccuagugaccgauagugaaccaguaccgugagggaaaggugaaaagcaccccggaaggggagugaaacaguuccugaaaccgugugccuacaaguaguuagagcccguuaaugggugauagcgugccuuuuguagaaugaaccggcgaguuacgauuuguugcaagguuaagcggaaaaagcggagccguagcgaaagcgagucugaauagggcgcauaaguaacaggucguagacccgaaaccaggugaucuacccauguccaggaugaagguaagguaauacuuacuggagguccgaacccacgcacguugaaaagugcggggaugagguguggguagcggagaaauuccaaucgaacuuggagauagcugguucucuccgaaauagcuuuagggcuagccucgagguaaagagucauggagguagagcacuguuuggacuaggggccgguuaccgaauucagauaaacuccgaaugccauguacuuauacucgggagucagacugcgagugauaagauccguagucgaaagggaaacagcccagaccaccaguuaagguccccaaauauauguuaaguggaaaaggaugugggguugcuuagacaaccaggauguuggcuuagaagcagccaccauugaaagagugcguaauagcucacuggucgagugaccccgcgccgaaaauguaccggggcuaaacauauuaccgaaacuguggaugaaccgguucgugguaggagagcguucuaagggcggugaagucagaccggaaggacugguggagcgcuuagaagugagaaugccgguaugaguagcgaaagaagggugagaaucccuuccaccgaauaucuaagguuuccugaggaaggcucguccgcucaggguuagucgggaccuaagccgaggccgauaggcguaggcgauggacaacagguagagauuccuguaccagugcuaauuguuuaaccgauggggugacacagaaggauagggaaucgcacgaauggaaaugugcguccaagcagugagugugagaaguaggcaaauccgcuucuugcgaagcaugagcugugauggggaagacggaaguuccugauuucacgcugucaagaaaagccucuaggaagaguaguacugcccguaccgcaaaccgacacagguagaugaggagagaauccuaaggugagcgagagaacucucguuaaggaacucggcaaaaugaccccguaacuucgggagaaggggugcucuauuagggugcaagcccgagagagccgcagugaauaggcccaggcgacuguuuagcaaaaacacaggucucugcaaaaccguaaggugacguauaggggcugacgccugcccggugcuggaagguuaagaggagugcuuagcuucggcgaagguacgaauugaagccccaguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgacccgcacgaaaggcgcaacgaucugggcacugucucaacgagagacucggugaaauuauaguaccugugaagaugcagguuacccgcgacaggacggaaagaccccguggagcuuuacugcaaccugauauggaauguuuguaccgcuuguacaggauagguaggagccgaagagacgugugcgcuagcauacgaggaggcaauggugggauacuacccuggcuguaugaccauucuaacccgccacgcuaagcgcguggggagacagugucaggugggcaguuugacuggggcggucgccuccuaaagaguaacggaggcgcccaaagguucccucagaauggauggaaaucauucgcagaguguaaaggcacaagggagcuugacugcgagacugacaagucgagcagggacgaaagucgggcuuagugauccggugguuccgcauggaagggccaucgcucaacggauaaaagcuaccccggggauaacaggcuuaucucccccaagaguccacaucgacggggagguuuggcaccucgaugucggcucgucgcauccuggggcuguagucggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucccuauccgucgcgggcgcaggaaauuugagaggagcuguccuuaguacgagaggaccgggauggacacaccgcugguguaccaguuguuccgccaggagcaucgcuggguagcuauguguggcagggauaaacgcugaaagcaucuaagcgugaagccccccucaagaugagauuucccauuucuucggaaaguaagaucccugaaagaugaucagguagauagguuuggaguggaaguguagcgauacauggagcggacaaauacuaaucgaucgaggacuuaacc <<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>....<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..(((....<<<<<<<<....>>>>>>>>......<<<<<<<<<<....<<<<........<<<<<<<<<.<<<.....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>.>>>>>>>>>>..>>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<......>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.......>>...>>>...<<....>>..<<<<.....>>>>......>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<.....<<<<<<<<<.....<<<...<<<<<<<<...<<.<<..>>..>>...>>>>>>>>..>>.>.....>>>>>.>>>>...>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<..>>>>>>....>>>>>><.<<<<<<<.<<......<<<<<.<<....>>.>>>>>...>>.>>>>>>>..>.....>>>>>><......<<....<<<<<<.......>>>>>><<<<....<<<<<.<<<..<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<.<<......<<...<<<<<...<<<<..<<<..<<<<<.<<<<<...(((....>>>>>.<<..<<<<<..<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>..>>>>>...>>............>>>>>...>>>...>>>>........>>>>>..>>..>>.>>>>>>>>>>>>.>>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<....<<<<....>>>>...>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>..<<<<.<<<..<<<<<<<..<<<...<<...<<<<<..<<....>>...>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>...>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<<.<<<<<.<<<<<<.<<<...........<<<<<..<<<.......<<<<<<<....>>>>>>>....>>>............>>>>>..>>>.>>>>>>.>>>>>....<<.<<<<<<.....>>>>>>>>.....>>>>>>>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<.........>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.)))>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>...>>>>....>>>>>>>. 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Cryo-EM structure of the ratcheted Listeria innocua 70S ribosome in complex with p/E-tRNA (structure II-A); 23S Ribosomal RNA 8uu6 B 114 3.3 RF00001 URS0002311A24_169963 38407413 0003735 0005840 1642 cugguaguuauggcgagaaggucacacccguucccaucccgaacacgguaguuaagcuucucugcgccaaugguaguugggggcuucccccugcgagaguaggucgcugccggg <<<<<<<<....<<<<<<<<.....<<<<<<.............>>>>..>>....>>>>>>.>><<<.......<<.<<<<<...>>>>>.>>.......>>>.>>>>>>>>. (((((((.....((((((((.....((((((...(.....)...))))..))....)))))).))(((.......((.(((((...))))).)).......)))..))))))). Cryo-EM structure of the ratcheted Listeria innocua 70S ribosome in complex with p/E-tRNA (structure II-A); 5S Ribosomal RNA 8uu7 a 1516 3.2 RF01959,RF00177,RF02542,RF01960 38407413 0003735 0005840 1642 aaagagaguuugauccuggcucaggacgaacgcuggcggcgugccuaauacaugcaagucgaacgaacggaaguuaguggcggacgggugaguaacacgugggcaaccugccuguaaguuggggauaacuccgggaaaccggggcuaauaccgaaugauagaguguggcgcaugccacgcucuugaaagaugguuucggcuaucgcuuacagaugggcccgcggugcauuagcuaguugguaggguaauggccuaccaaggcaacgaugcauagccgaccugagagggugaucggccacacugggacugagacacggcccagacuccuacgggaggcagcaguagggaaucuuccgcaauggacgaaagucugacggagcaacgccgcguguaugaagaagguuuucggaucguaaaguacuguuguuagagaagaacaaggauaagaguaacugcuugucccuugacgguaucuaaccagaaagccacggcuaacuacgugccagcagccgcgguaauacguagguggcaagcguuguccggauuuauugggcguaaagcgcgcgcaggcggucuuuuaagucugaugugaaagcccccggcuuaaccggggagggucauuggaaacuggaagacuggagugcagaagaggagaguggaauuccacguguagcggugaaaugcguagauauguggaggaacaccaguggcgaaggcgacucucuggucuguaacugacgcugaggcgcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugagugcuaaguguuaggggguuuccgccccuuagugcugcagcuaacgcauuaagcacuccgccuggggaguacgaccgcaagguugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggucuugacauccuuugaccacucuggagacagagcuuucccgggacaaagugacagguggugcaugguugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuugauuuuaguugccagcauuuaguugggcacucuaaagugacugccggugcaagccggaggaagguggggaugacgucaaaucaucaugccccuuaugaccugggcuacacacgugcuacaauggaugguacaaagggucgcgaagccgcgagguggagccaaucccauaaaaccauucucaguucggauuguaggcugcaacucgccuacaugaagccggaaucgcuaguaaucguggaucagcaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccacgagaguuuguaacacccgaagucgguaggguaaccggagccagccgccgaaggugggacagauaauuggggugaagucguaacaagguagccguaucggaaggugcggcuggaucaccuccu .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<<....>>>.>>>>>......<<........<<<<<<<..<<...<<<<<<<<<.<<.....<<<<<<....>>>>>>......>>.>.....<<<<<<<<<<....>>>>>>>>>>.....<<<<<<....>>>>>>>>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<<<<<<<.......<.<<<<<<<........>>>>>>>.>........>>>>>>...>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<.......<<<<<<.....>>>>>>.....>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<<..<<<......>>>.....>>>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<<....>>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<....<<<<<....>>>>>....<<<>>>.>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<......>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<..<<<<....<.<<<<..<<<..<<>>.>>>.>>>>.>...>>>>..>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((......)).)))))......(((.......(((((((..((...(((((((((.((.....((((((....))))))......)).).....((((((((((....)))))))))).....((((((....))))))))))))))..))))))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....((((((...(.....(((((((........))))))).....)....))))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))...).)))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((((((....)))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((.((((....(((((....)))))....((())).))))..))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..((......)))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...((((((......(((..((...(((....)))...))....)))......))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((..((((....(.((((..(((..(()).))).)))).)...))))..))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Cryo-EM structure of the Listeria innocua 70S ribosome in complex with HflXr, HPF, and E-site tRNA (structure II-B); 16S Ribosomal RNA 8uu7 y 74 3.2 RF00005 38407413 0030533 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<......>>>><<<<<<.......>>>>>.>...<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[..)))).((((.........)))).....(((.(..].....))))))))))).... Cryo-EM structure of the Listeria innocua 70S ribosome in complex with HflXr, HPF, and E-site tRNA (structure II-B); E-site Phenylalanine tRNA 8uu7 A 2909 3.2 RF02541 38407413 0003735 0005840 1642 guuaaguuagaaagggcgcacgguggaugccuuggcacuaggagccgaagaaggacgggacuaacaccgauaugcuuuggggagcuguacguaagcguugauccagagauuuccgaaugggggaacccacuaucuuuagucggauaguauccuuacgugaauacauagcgugaggaaggcagacccagggaacugaaacaucuaaguaccuggaggaagagaaagaaaaaucgauuuccugaguagcggcgagcgaaacggaaagagcccaaaccaagaagcuugcuucuugggguuguaggacacucuauacggaguuacaaaagaaaguuauaaaugaagcggucuggaaaggcccgccaaagacgguaacagcccgguaguugaaauggcuuucccuccagaguggauccugaguacgacggaacacgugaaauuccgucggaauccgggaggaccaucucccaaggcuaaauacucccuagugaccgauagugaaccaguaccgugagggaaaggugaaaagcaccccggaaggggagugaaacaguuccugaaaccgugugccuacaaguaguuagagcccguuaaugggugauagcgugccuuuuguagaaugaaccggcgaguuacgauuuguugcaagguuaagcggaaaaagcggagccguagcgaaagcgagucugaauagggcgcauaaguaacaggucguagacccgaaaccaggugaucuacccauguccaggaugaagguaagguaauacuuacuggagguccgaacccacgcacguugaaaagugcggggaugagguguggguagcggagaaauuccaaucgaacuuggagauagcugguucucuccgaaauagcuuuagggcuagccucgagguaaagagucauggagguagagcacuguuuggacuaggggccgguuaccgaauucagauaaacuccgaaugccauguacuuauacucgggagucagacugcgagugauaagauccguagucgaaagggaaacagcccagaccaccaguuaagguccccaaauauauguuaaguggaaaaggaugugggguugcuuagacaaccaggauguuggcuuagaagcagccaccauugaaagagugcguaauagcucacuggucgagugaccccgcgccgaaaauguaccggggcuaaacauauuaccgaaacuguggaugaaccuagguucgugguaggagagcguucuaagggcggugaagucagaccggaaggacugguggagcgcuuagaagugagaaugccgguaugaguagcgaaagaagggugagaaucccuuccaccgaauaucuaagguuuccugaggaaggcucguccgcucaggguuagucgggaccuaagccgaggccgauaggcguaggcgauggacaacagguagagauuccuguaccagugcuaauuguuuaaccgauggggugacacagaaggauagggaaucgcacgaauggaaaugugcguccaagcagugagugugagaaguaggcaaauccgcuucuugcgaagcaugagcugugauggggaaggguacggaaguuccugauuucacgcugucaagaaaagccucuaggaagaguaguacugcccguaccgcaaaccgacacagguagaugaggagagaauccuaaggugagcgagagaacucucguuaaggaacucggcaaaaugaccccguaacuucgggagaaggggugcucuauuagggugcaagcccgagagagccgcagugaauaggcccaggcgacuguuuagcaaaaacacaggucucugcaaaaccguaaggugacguauaggggcugacgccugcccggugcuggaagguuaagaggagugcuuagcuucggcgaagguacgaauugaagccccaguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgacccgcacgaaaggcgcaacgaucugggcacugucucaacgagagacucggugaaauuauaguaccugugaagaugcagguuacccgcgacaggacggaaagaccccguggagcuuuacugcaaccugauauggaauguuuguaccgcuuguacaggauagguaggagccgaagagacgugugcgcuagcauacgaggaggcaauggugggauacuacccuggcuguaugaccauucuaacccgccacgcuaagcgcguggggagacagugucaggugggcaguuugacuggggcggucgccuccuaaagaguaacggaggcgcccaaagguucccucagaauggauggaaaucauucgcagaguguaaaggcacaagggagcuugacugcgagacugacaagucgagcagggacgaaagucgggcuuagugauccggugguuccgcauggaagggccaucgcucaacggauaaaagcuaccccggggauaacaggcuuaucucccccaagaguccacaucgacggggagguuuggcaccucgaugucggcucgucgcauccuggggcuguagucggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucccuauccgucgcgggcgcaggaaauuugagaggagcuguccuuaguacgagaggaccgggauggacacaccgcugguguaccaguuguuccgccaggagcaucgcuggguagcuauguguggcagggauaaacgcugaaagcaucuaagcgugaagccccccucaagaugagauuucccauuucuucggaaaguaagaucccugaaagaugaucagguagauagguuuggaguggaaguguagcgauacauggagcggacaaauacuaaucgaucgaggacuuaacc <<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>....<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..(((....<<<<<<<<....>>>>>>>>......<<<<<<<<<<....<<<<........<<<<<<<<<.<<<.....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>.>>>>>>>>>>..>>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<......>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.......>>...>>>...<<....>>..<<<<.....>>>>......>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<.....<<<<<<<<<.....<<<...<<<<<<<<...<<.<<..>>..>>...>>>>>>>>..>>.>.....>>>>>.>>>>...>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<..>>>>>>>....>>>>>><.<<<<<<<.<<......<<<<<.<<....>>.>>>>>...>>.>>>>>>>..>.....>>>>>><......<<....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<.<<......<<...<<<<<...<<<<..<<<..<<<<<.<<<<<...(((....>>>>>.<<..<<<<<..<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>..>>>>>...>>....<....>.....>>>>>...>>>...>>>>........>>>>>..>>..>>.>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<....<<<<....>>>>...>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>..<<<<.<<<..<<<<<<<..<<<...<<...<<<<<<.<<....>>..>>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>...>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<<.<<<<<.<<<<<<.<<<...........<<<<<..<<<.......<<<<<<<....>>>>>>>....>>>............>>>>>..>>>.>>>>>>.>>>>>....<<.<<<<<<.....>>>>>>>>.....>>>>>>>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.)))>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<..>>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>...>>>>....>>>>>>>. 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Cryo-EM structure of the Listeria innocua 70S ribosome in complex with HflXr, HPF, and E-site tRNA (structure II-B); 23S Ribosomal RNA 8uu7 B 114 3.2 RF00001 URS0002311A24_169963 38407413 0003735 0005840 1642 cugguaguuauggcgagaaggucacacccguucccaucccgaacacgguaguuaagcuucucugcgccaaugguaguugggggcuucccccugcgagaguaggucgcugccggg <<<<<<<<....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>><<<.......<<.<<<<<...>>>>>.>>.......>>>.>>>>>>>>. ((((((((....((((((((.....((((((...(.....)...))))..))....)))))).))(((.......((.(((((...))))).)).......))).)))))))). Cryo-EM structure of the Listeria innocua 70S ribosome in complex with HflXr, HPF, and E-site tRNA (structure II-B); 5S Ribosomal RNA 8uu8 a 1516 3.1 RF01959,RF00177,RF02542,RF01960 38407413 0003735 0005840 1642 aaagagaguuugauccuggcucaggacgaacgcuggcggcgugccuaauacaugcaagucgaacgaacggaaguuaguggcggacgggugaguaacacgugggcaaccugccuguaaguuggggauaacuccgggaaaccggggcuaauaccgaaugauagaguguggcgcaugccacgcucuugaaagaugguuucggcuaucgcuuacagaugggcccgcggugcauuagcuaguugguaggguaauggccuaccaaggcaacgaugcauagccgaccugagagggugaucggccacacugggacugagacacggcccagacuccuacgggaggcagcaguagggaaucuuccgcaauggacgaaagucugacggagcaacgccgcguguaugaagaagguuuucggaucguaaaguacuguuguuagagaagaacaaggauaagaguaacugcuugucccuugacgguaucuaaccagaaagccacggcuaacuacgugccagcagccgcgguaauacguagguggcaagcguuguccggauuuauugggcguaaagcgcgcgcaggcggucuuuuaagucugaugugaaagcccccggcuuaaccggggagggucauuggaaacuggaagacuggagugcagaagaggagaguggaauuccacguguagcggugaaaugcguagauauguggaggaacaccaguggcgaaggcgacucucuggucuguaacugacgcugaggcgcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugagugcuaaguguuaggggguuuccgccccuuagugcugcagcuaacgcauuaagcacuccgccuggggaguacgaccgcaagguugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggucuugacauccuuugaccacucuggagacagagcuuucccgggacaaagugacagguggugcaugguugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuugauuuuaguugccagcauuuaguugggcacucuaaagugacugccggugcaagccggaggaagguggggaugacgucaaaucaucaugccccuuaugaccugggcuacacacgugcuacaauggaugguacaaagggucgcgaagccgcgagguggagccaaucccauaaaaccauucucaguucggauuguaggcugcaacucgccuacaugaagccggaaucgcuaguaaucguggaucagcaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccacgagaguuuguaacacccgaagucgguaggguaaccggagccagccgccgaaggugggacagauaauuggggugaagucguaacaagguagccguaucggaaggugcggcuggaucaccuccu .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<<....>>>.>>>>>......<<........<<<<<<<..<<...<<<<<<<<<.<<.....<<<<<<....>>>>>>......>>.>.....<<<<<<<<<<....>>>>>>>>>>.....<<<<<<....>>>>>>>>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<<<<<<<.........<<<<<<<........>>>>>>>..........>>>>>>...>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<.......<<<<<<.....>>>>>>.....>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<<....>>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<........<<........>>.............<<<<......<<<<<<.....<<<<<....>>>>>....<<<>>>..>>>>.>>.<<<.<<<..<<<<<........<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<..<<<<<<<..<<<..<<......>>>>>...>>>>>>>.....<<<<<....>>>>>.........>>>..........>...>>>>>>>>>>...>>>>.........>>>>>>>>.....<<<<<<<.....<<<..<....<<......>>....>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<..<<<<....<.<<<<..<<<..<<>>.>>>.>>>>.>...>>>>..>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .....((((....[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((....))).)))))......(((.......(((((((..((...(((((((((.((.....((((((....))))))......)).).....((((((((((....)))))))))).....((((........))))))))))))..))))))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....((((((...(.....(((((((........))))))).....)....))))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))...).)))))))..)))))))))..(((((((((...((((((((....(((((.....((........))........)))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((......))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]]..(((((.((((((..((.((((((..(((..((((.......((........)).............((((..(...((.((((....(((((....)))))....((())).))))..))).((.((....((...(.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..((......)))))...)))))))..(..((((......)))).....)..)))).....).).......))..))))....)))).......).)))..))).....(..(.(......(((..((.....(.....)....))....)))......).)..)......(.....((((((........)))))).....).....))))))....(.(((((.........))))).)......))....))))))))).))..(.(..((.(.((((.(((..((((((..((((....(.((((..(((..(()).))).)))).)...))))..))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Cryo-EM structure of the Listeria innocua 70S ribosome (head-swiveled) in complex with HflXr and pe/E-tRNA (structure II-C); 16S Ribosomal RNA 8uu8 x 74 3.1 RF00005 38407413 0030533 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[..)))).((((.........)))).....((.((..]....)).))))))))).... Cryo-EM structure of the Listeria innocua 70S ribosome (head-swiveled) in complex with HflXr and pe/E-tRNA (structure II-C); pe/E Hybrid State Phenylalanine tRNA 8uu8 A 2901 3.1 RF02541 38407413 0003735 0005840 1642 guuaaguuagaaagggcgcacgguggaugccuuggcacuaggagccgaagaaggacgggacuaacaccgauaugcuuuggggagcuguacguaagcguugauccagagauuuccgaaugggggaacccacuaucuuuagucggauaguauccuuacgugaauacauagcgugaggaaggcagacccagggaacugaaacaucuaaguaccuggaggaagagaaagaaaaaucgauuuccugaguagcggcgagcgaaacggaaagagcccaaaccaagaagcuugcuucuugggguuguaggacacucuauacggaguuacaaaagaaaguuauaaaugaagcggucuggaaaggcccgccaaagacgguaacagcccgguaguugaaauggcuuucccuccagaguggauccugaguacgacggaacacgugaaauuccgucggaauccgggaggaccaucucccaaggcuaaauacucccuagugaccgauagugaaccaguaccgugagggaaaggugaaaagcaccccggaaggggagugaaacaguuccugaaaccgugugccuacaaguaguuagagcccguuaaugggugauagcgugccuuuuguagaaugaaccggcgaguuacgauuuguugcaagguuaagcggaaaaagcggagccguagcgaaagcgagucugaauagggcgcauaaguaacaggucguagacccgaaaccaggugaucuacccauguccaggaugaagguaagguaauacuuacuggagguccgaacccacgcacguugaaaagugcggggaugagguguggguagcggagaaauuccaaucgaacuuggagauagcugguucucuccgaaauagcuuuagggcuagccucgagguaaagagucauggagguagagcacuguuuggacuaggguaccgaauucagauaaacuccgaaugccauguacuuauacucgggagucagacugcgagugauaagauccguagucgaaagggaaacagcccagaccaccaguuaagguccccaaauauauguuaaguggaaaaggaugugggguugcuuagacaaccaggauguuggcuuagaagcagccaccauugaaagagugcguaauagcucacuggucgagugaccccgcgccgaaaauguaccggggcuaaacauauuaccgaaacuguggaugaaccuagguucgugguaggagagcguucuaagggcggugaagucagaccggaaggacugguggagcgcuuagaagugagaaugccgguaugaguagcgaaagaagggugagaaucccuuccaccgaauaucuaagguuuccugaggaaggcucguccgcucaggguuagucgggaccuaagccgaggccgauaggcguaggcgauggacaacagguagagauuccuguaccagugcuaauuguuuaaccgauggggugacacagaaggauagggaaucgcacgaauggaaaugugcguccaagcagugagugugagaaguaggcaaauccgcuucuugcgaagcaugagcugugauggggaaguacggaaguuccugauuucacgcugucaagaaaagccucuaggaagaguaguacugcccguaccgcaaaccgacacagguagaugaggagagaauccuaaggugagcgagagaacucucguuaaggaacucggcaaaaugaccccguaacuucgggagaaggggugcucuauuagggugcaagcccgagagagccgcagugaauaggcccaggcgacuguuuagcaaaaacacaggucucugcaaaaccguaaggugacguauaggggcugacgccugcccggugcuggaagguuaagaggagugcuuagcuucggcgaagguacgaauugaagccccaguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgacccgcacgaaaggcgcaacgaucugggcacugucucaacgagagacucggugaaauuauaguaccugugaagaugcagguuacccgcgacaggacggaaagaccccguggagcuuuacugcaaccugauauggaauguuuguaccgcuuguacaggauagguaggagccgaagagacgugugcgcuagcauacgaggaggcaauggugggauacuacccuggcuguaugaccauucuaacccgccacgcuaagcgcguggggagacagugucaggugggcaguuugacuggggcggucgccuccuaaagaguaacggaggcgcccaaagguucccucagaauggauggaaaucauucgcagaguguaaaggcacaagggagcuugacugcgagacugacaagucgagcagggacgaaagucgggcuuagugauccggugguuccgcauggaagggccaucgcucaacggauaaaagcuaccccggggauaacaggcuuaucucccccaagaguccacaucgacggggagguuuggcaccucgaugucggcucgucgcauccuggggcuguagucggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucccuauccgucgcgggcgcaggaaauuugagaggagcuguccuuaguacgagaggaccgggauggacacaccgcugguguaccaguuguuccgccaggagcaucgcuggguagcuauguguggcagggauaaacgcugaaagcaucuaagcgugaagccccccucaagaugagauuucccauuucuucggaaaguaagaucccugaaagaugaucagguagauagguuuggaguggaaguguagcgauacauggagcggacaaauacuaaucgaucgaggacuuaacc <<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<.[...((.>>>.....<<<<<<<..<<<))...].>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>....<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..(((....<<<<<<<<....>>>>>>>>......<<<<<<<<<<....<<<<........<<<<<<<<<.<<<.....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>.>>>>>>>>>>..>>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<......>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.......>>...>>>...<<....>>..<<<<.....>>>>......>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<.....<<<<<<<<<.....<<<...<<<<<<<<...<<...>>...>>>>>>>>..>>.>.....>>>>>.>>>>...>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<<<......<<<<<.<<<..<<<<.......>>>>..>>>.........<<......>>...>>>>>..>>>>>>>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<..>>>>>>>....>>>>>><.<<<<<<<.<<......<<<<<.<<....>>.>>>>>...>>.>>>>>>>..>.....>>>>>><......<<....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<.<<......<<...<<<<<...<<<<..<<<..<<<<<.<<<<<...(((....>>>>>.<<..<<<<<..<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>..>>>>>...>>.............>>>>>...>>>...>>>>........>>>>>..>>..>>.>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<....<<<<....>>>>...>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>..<<<<.<<<..<<<<<<<..<<<<..<<...<<<<<<.<<....>>..>>>>>>...>>..>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>...>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<<.<<<<<.<<<<<<.<<<...........<<<<<..<<<.......<<<<<<<....>>>>>>>....>>>............>>>>>..>>>.>>>>>>.>>>>>....<<.<<<<<<.....>>>>>>>>.....>>>>>>>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<.<......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.)))>>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>...>>>>....>>>>>>>. 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Cryo-EM structure of the Listeria innocua 70S ribosome (head-swiveled) in complex with HflXr and pe/E-tRNA (structure II-C); 23S Ribosomal RNA 8uu8 B 114 3.1 RF00001 URS0002311A24_169963 38407413 0003735 0005840 1642 cugguaguuauggcgagaaggucacacccguucccaucccgaacacgguaguuaagcuucucugcgccaaugguaguugggggcuucccccugcgagaguaggucgcugccggg <<<<<<<<....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>><<<.......<<.<<<<<...>>>>>.>>.......>>>.>>>>>>>>. ((((((((....((((((((.....((((((...(.....)...))))..))....)))))).))(((.......((.(((((...))))).)).......))).)))))))). Cryo-EM structure of the Listeria innocua 70S ribosome (head-swiveled) in complex with HflXr and pe/E-tRNA (structure II-C); 5S Ribosomal RNA 8uu9 a 1515 3.1 RF01959,RF00177,RF02542,RF01960 38407413 0003735 0005840 1642 aagagaguuugauccuggcucaggacgaacgcuggcggcgugccuaauacaugcaagucgaacgaacggaaguuaguggcggacgggugaguaacacgugggcaaccugccuguaaguuggggauaacuccgggaaaccggggcuaauaccgaaugauagaguguggcgcaugccacgcucuugaaagaugguuucggcuaucgcuuacagaugggcccgcggugcauuagcuaguugguaggguaauggccuaccaaggcaacgaugcauagccgaccugagagggugaucggccacacugggacugagacacggcccagacuccuacgggaggcagcaguagggaaucuuccgcaauggacgaaagucugacggagcaacgccgcguguaugaagaagguuuucggaucguaaaguacuguuguuagagaagaacaaggauaagaguaacugcuugucccuugacgguaucuaaccagaaagccacggcuaacuacgugccagcagccgcgguaauacguagguggcaagcguuguccggauuuauugggcguaaagcgcgcgcaggcggucuuuuaagucugaugugaaagcccccggcuuaaccggggagggucauuggaaacuggaagacuggagugcagaagaggagaguggaauuccacguguagcggugaaaugcguagauauguggaggaacaccaguggcgaaggcgacucucuggucuguaacugacgcugaggcgcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugagugcuaaguguuaggggguuuccgccccuuagugcugcagcuaacgcauuaagcacuccgccuggggaguacgaccgcaagguugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaggucuugacauccuuugaccacucuggagacagagcuuucccgggacaaagugacagguggugcaugguugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuugauuuuaguugccagcauuuaguugggcacucuaaagugacugccggugcaagccggaggaagguggggaugacgucaaaucaucaugccccuuaugaccugggcuacacacgugcuacaauggaugguacaaagggucgcgaagccgcgagguggagccaaucccauaaaaccauucucaguucggauuguaggcugcaacucgccuacaugaagccggaaucgcuaguaaucguggaucagcaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccacgagaguuuguaacacccgaagucgguaggguaaccggagccagccgccgaaggugggacagauaauuggggugaagucguaacaagguagccguaucggaaggugcggcuggaucaccuccu ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<......>>.>>>>>......<<........<<<<<<<..<<...<<<<<<<<<.<<.....<<<<<<....>>>>>>......>>.>.....<<<<<<<<<<....>>>>>>>>>>.....<<<<<<....>>>>>>>>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<<<<<<<.......<.<<<<<<<........>>>>>>>.>........>>>>>>...>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<.......<<<<<<.....>>>>>>.....>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<<..<<<......>>>.....>>>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<<....>>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<....<<<<<....>>>>>....<<<>>>.>>>>>.>>.<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<......>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<..<<<<....<.<<<<..<<<..<<>>.>>>.>>>>.>...>>>>..>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((..((....))..)))))......(((.......(((((((..((...(((((((((.((.....((((((....))))))......)).).....((((((((((....)))))))))).....((((((....))))))))))))))..))))))))).(((....((...((((((((.......)))))))).))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....((((((...(.....(((((((........))))))).....)....))))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))...).)))))))..)))))))))..(((((((((...((((((((....(((((.(...((........))......).)))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((((((....)))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((....(((((....)))))....((())).))))).))).((.(((...((.(((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..((......)))))...)))))))..(..(((((....))))).....)..)))).....).).))....)).)))))....)))))))...)).)))))))).(...((((((......(((..((...(((....)))...))....)))......))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((..((((....(.((((..(((..(()).))).)))).)...))))..))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Cryo-EM structure of the ratcheted Listeria innocua 70S ribosome (head-swiveled) in complex with HflXr and pe/E-tRNA (structure II-D); 16S Ribosomal RNA 8uu9 x 74 3.1 RF00005 38407413 0030533 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[..)))).((((.........)))).....((.((..]....)).))))))))).... Cryo-EM structure of the ratcheted Listeria innocua 70S ribosome (head-swiveled) in complex with HflXr and pe/E-tRNA (structure II-D); pe/E Hybrid State Phenylalanine tRNA 8uu9 A 2899 3.1 RF02541 38407413 0003735 0005840 1642 uuaaguuagaaagggcgcacgguggaugccuuggcacuaggagccgaagaaggacgggacuaacaccgauaugcuuuggggagcuguacguaagcguugauccagagauuuccgaaugggggaacccacuaucuuuagucggauaguauccuuacgugaauacauagcgugaggaaggcagacccagggaacugaaacaucuaaguaccuggaggaagagaaagaaaaaucgauuuccugaguagcggcgagcgaaacggaaagagcccaaaccaagaagcuugcuucuugggguuguaggacacucuauacggaguuacaaaagaaaguuauaaaugaagcggucuggaaaggcccgccaaagacgguaacagcccgguaguugaaauggcuuucccuccagaguggauccugaguacgacggaacacgugaaauuccgucggaauccgggaggaccaucucccaaggcuaaauacucccuagugaccgauagugaaccaguaccgugagggaaaggugaaaagcaccccggaaggggagugaaacaguuccugaaaccgugugccuacaaguaguuagagcccguuaaugggugauagcgugccuuuuguagaaugaaccggcgaguuacgauuuguugcaagguuaagcggaaaaagcggagccguagcgaaagcgagucugaauagggcgcauaaguaacaggucguagacccgaaaccaggugaucuacccauguccaggaugaagguaagguaauacuuacuggagguccgaacccacgcacguugaaaagugcggggaugagguguggguagcggagaaauuccaaucgaacuuggagauagcugguucucuccgaaauagcuuuagggcuagccucgagguaaagagucauggagguagagcacuguuuggacuaggggaccgaauucagauaaacuccgaaugccauguacuuauacucgggagucagacugcgagugauaagauccguagucgaaagggaaacagcccagaccaccaguuaagguccccaaauauauguuaaguggaaaaggaugugggguugcuuagacaaccaggauguuggcuuagaagcagccaccauugaaagagugcguaauagcucacuggucgagugaccccgcgccgaaaauguaccggggcuaaacauauuaccgaaacuguggaugaaccuagguucgugguaggagagcguucuaagggcggugaagucagaccggaaggacugguggagcgcuuagaagugagaaugccgguaugaguagcgaaagaagggugagaaucccuuccaccgaauaucuaagguuuccugaggaaggcucguccgcucaggguuagucgggaccuaagccgaggccgauaggcguaggcgauggacaacagguagagauuccuguaccagugcuaauuguuuaaccgauggggugacacagaaggauagggaaucgcacgaauggaaaugugcguccaagcagugagugugagaaguaggcaaauccgcuucuugcgaagcaugagcugugauggggaagacggaaguuccugauuucacgcugucaagaaaagccucuaggaagaguaguacugcccguaccgcaaaccgacacagguagaugaggagagaauccuaaggugagcgagagaacucucguuaaggaacucggcaaaaugaccccguaacuucgggagaaggggugcucuauuagggugcaagcccgagagagccgcagugaauaggcccaggcgacuguuuagcaaaaacacaggucucugcaaaaccguaaggugacguauaggggcugacgccugcccggugcuggaagguuaagaggagugcuuagcuucggcgaagguacgaauugaagccccaguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgacccgcacgaaaggcgcaacgaucugggcacugucucaacgagagacucggugaaauuauaguaccugugaagaugcagguuacccgcgacaggacggaaagaccccguggagcuuuacugcaaccugauauggaauguuuguaccgcuuguacaggauagguaggagccgaagagacgugugcgcuagcauacgaggaggcaauggugggauacuacccuggcuguaugaccauucuaacccgccacgcuaagcgcguggggagacagugucaggugggcaguuugacuggggcggucgccuccuaaagaguaacggaggcgcccaaagguucccucagaauggauggaaaucauucgcagaguguaaaggcacaagggagcuugacugcgagacugacaagucgagcagggacgaaagucgggcuuagugauccggugguuccgcauggaagggccaucgcucaacggauaaaagcuaccccggggauaacaggcuuaucucccccaagaguccacaucgacggggagguuuggcaccucgaugucggcucgucgcauccuggggcuguagucggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucccuauccgucgcgggcgcaggaaauuugagaggagcuguccuuaguacgagaggaccgggauggacacaccgcugguguaccaguuguuccgccaggagcaucgcuggguagcuauguguggcagggauaaacgcugaaagcaucuaagcgugaagccccccucaagaugagauuucccauuucuucggaaaguaagaucccugaaagaugaucagguagauagguuuggaguggaaguguagcgauacauggagcggacaaauacuaaucgaucgaggacuuaacc <<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>....<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..(((....<<<<<<<<....>>>>>>>>......<<<<<<<<<<....<<<<........<<<<<<<<<.<<<.....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>.>>>>>>>>>>..>>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<......>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.......>>...>>>...<<....>>..<<<<.....>>>>......>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<.....<<<<<<<<<.....<<<...<<<<<<<<...<<...>>...>>>>>>>>..>>.>.....>>>>>.>>>>...>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>...>>>>>>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<..>>>>>>>....>>>>>><.<<<<<<<.<<......<<<<<.<<....>>.>>>>>...>>.>>>>>>>..>.....>>>>>><......<<....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<.<<......<<...<<<<<...<<<<..<<<..<<<<<.<<<<<...(((....>>>>>.<<..<<<<<..<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>..>>>>>...>>............>>>>>...>>>...>>>>........>>>>>..>>..>>.>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<....<<<<....>>>>...>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>..<<<<.<<<..<<<<<<<..<<<<..<<...<<<<<<.<<<..>>>..>>>>>>...>>..>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>...>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<<.<<<<<.<<<<<<.<<<.<.........<<<<<..<<<.......<<<<<<<....>>>>>>>....>>>............>>>>>>.>>>.>>>>>>.>>>>>....<<.<<<<<<.....>>>>>>>>.....>>>>>>>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<.<......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.)))>>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<<..>>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>...>>>>....>>>>>>.. 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Cryo-EM structure of the ratcheted Listeria innocua 70S ribosome (head-swiveled) in complex with HflXr and pe/E-tRNA (structure II-D); 23S Ribosomal RNA 8uu9 B 114 3.1 RF00001 URS0002311A24_169963 38407413 0003735 0005840 1642 cugguaguuauggcgagaaggucacacccguucccaucccgaacacgguaguuaagcuucucugcgccaaugguaguugggggcuucccccugcgagaguaggucgcugccggg <<<<<<<<....<<<<<<<<.....<<<<<<.............>>>>..>>....>>>>>>.>><<<.......<<.<<<<<...>>>>>.>>.......>>>.>>>>>>>>. ((((((((....((((((((.....((((((...(.....)...))))..))....)))))).))(((.......((.(((((...))))).)).......))).)))))))). Cryo-EM structure of the ratcheted Listeria innocua 70S ribosome (head-swiveled) in complex with HflXr and pe/E-tRNA (structure II-D); 5S Ribosomal RNA 8uua A 2894 2.7 RF02541 38407413 0003735 0005840 1642 guuaaguuagaaagggcgcacgguggaugccuuggcacuaggagccgaagaaggacgggacuaacaccgauaugcuuuggggagcuguacguaagcguugauccagagauuuccgaaugggggaacccacuaucuuuagucggauaguauccuuacgugaauacauagcgugaggaaggcagacccagggaacugaaacaucuaaguaccuggaggaagagaaagaaaaaucgauuuccugaguagcggcgagcgaaacggaaagagcccaaaccaagaagcuugcuucuugggguuguaggacacucuauacggaguuacaaaagaaaguuauaaaugaagcggucuggaaaggcccgccaaagacgguaacagcccgguaguugaaauggcuuucccuccagaguggauccugaguacgacggaacacgugaaauuccgucggaauccgggaggaccaucucccaaggcuaaauacucccuagugaccgauagugaaccaguaccgugagggaaaggugaaaagcaccccggaaggggagugaaacaguuccugaaaccgugugccuacaaguaguuagagcccguuaaugggugauagcgugccuuuuguagaaugaaccggcgaguuacgauuuguugcaagguuaagcggaaaaagcggagccguagcgaaagcgagucugaauagggcgcauaaguaacaggucguagacccgaaaccaggugaucuacccauguccaggaugaagguaagguaauacuuacuggagguccgaacccacgcacguugaaaagugcggggaugagguguggguagcggagaaauuccaaucgaacuuggagauagcugguucucuccgaaauagcuuuagggcuagccucgagguaaagagucauggagguagagcacuguuuggacuagcgaauucagauaaacuccgaaugccauguacuuauacucgggagucagacugcgagugauaagauccguagucgaaagggaaacagcccagaccaccaguuaagguccccaaauauauguuaaguggaaaaggaugugggguugcuuagacaaccaggauguuggcuuagaagcagccaccauugaaagagugcguaauagcucacuggucgagugaccccgcgccgaaaauguaccggggcuaaacauauuaccgaaacuguggaugaaccuagguucgugguaggagagcguucuaagggcggugaagucagaccggaaggacugguggagcgcuuagaagugagaaugccgguaugaguagcgaaagaagggugagaaucccuuccaccgaauaucuaagguuuccugaggaaggcucguccgcucaggguuagucgggaccuaagccgaggccgauaggcguaggcgauggacaacagguagagauuccuguaccagugcuaauuguuuaaccgauggggugacacagaaggauagggaaucgcacgaauggaaaugugcguccaagcagugagugugagaaguaggcaaauccgcuucuugcgaagcaugagcugugauggggaagcggaaguuccugauuucacgcugucaagaaaagccucuaggaagaguaguacugcccguaccgcaaaccgacacagguagaugaggagagaauccuaaggugagcgagagaacucucguuaaggaacucggcaaaaugaccccguaacuucgggagaaggggugcucuauuagggugcaagcccgagagagccgcagugaauaggcccaggcgacuguuuagcaaaaacacaggucucugcaaaaccguaaggugacguauaggggcugacgccugcccggugcuggaagguuaagaggagugcuuagcuucggcgaagguacgaauugaagccccaguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgacccgcacgaaaggcgcaacgaucugggcacugucucaacgagagacucggugaaauuauaguaccugugaagaugcagguuacccgcgacaggacggaaagaccccguggagcuuuacugcaaccugauauggaauguuuguaccgcuuguacaggauagguaggagccgaagagacgugugcgcuagcauacgaggaggcaauggugggauacuacccuggcuguaugaccauucuaacccgccacgcuaagcgcguggggagacagugucaggugggcaguuugacuggggcggucgccuccuaaagaguaacggaggcgcccaaagguucccucagaauggauggaaaucauucgcagaguguaaaggcacaagggagcuugacugcgagacugacaagucgagcagggacgaaagucgggcuuagugauccggugguuccgcauggaagggccaucgcucaacggauaaaagcuaccccggggauaacaggcuuaucucccccaagaguccacaucgacggggagguuuggcaccucgaugucggcucgucgcauccuggggcuguagucggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucccuauccgucgcgggcgcaggaaauuugagaggagcuguccuuaguacgagaggaccgggauggacacaccgcugguguaccaguuguuccgccaggagcaucgcuggguagcuauguguggcagggauaaacgcugaaagcaucuaagcgugaagccccccucaagaugagauuucccauuucuucggaaaguaagaucccugaaagaugaucagguagauagguuuggaguggaaguguagcgauacauggagcggacaaauacuaaucgaucgaggacuuaacc <<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>....<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..(((....<<<<<<<<....>>>>>>>>......<<<<<<<<<<....<<<<........<<<<<<<<<.<<<.....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>.>>>>>>>>>>..>>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<......>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.......>>...>>>...<<....>>..<<<<.....>>>>......>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<.....<<<<<<<<<.....<<<...<<<<<<<<........>>>>>>>>..>>.>.....>>>>>.>>>>...>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<<.......<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>...>>>>>>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<..>>>>>>>....>>>>>><.<<<<<<<.<<......<<<<<.<<....>>.>>>>>...>>.>>>>>>>..>.....>>>>>><......<<....<<<<<<.......>>>>>><<<<....<<<<<.<<<..<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<.<<......<<...<<<<<...<<<<..<<<..<<<<<.<<<<<...(((....>>>>>.<<..<<<<<..<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>..>>>>>...>>...........>>>>>...>>>...>>>>........>>>>>..>>..>>.>>>>>>>>>>>>.>>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<....<<<<....>>>>...>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>..<<<<.<<<..<<<<<<<..<<<<..<<...<<<<<<.<<....>>..>>>>>>...>>..>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>...>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<<.<<<<<.<<<<<<.<<<.<.........<<<<<..<<<.......<<<<<<<....>>>>>>>....>>>............>>>>>>.>>>.>>>>>>.>>>>>....<<.<<<<<<.....>>>>>>>>.....>>>>>>>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.)))>>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>...>>>>....>>>>>>>. (((((((......((((((((((.....(((..(((((((((((((......((((((.[[..[[[)))...].((((((...(((]]..]].)))......))))))...)))....(((....)))(((((((......))))))).(((((((((.........))))))))).))....((((((.....(...[..)......))))).).........((....))...((((......((.]...)).....))))...((((...(((((((((..)))))))))....{.((((((((((....((((........(((((((((.(((...(.((((......)))))[[(...).(((.....]])))...)))...))))))))).))))))))))..)))))....((((((((..[......))))))))....}.(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((..((((..[...))))..)))).<.(.(........).).((((((....(((((((((((((..(((...((.......))...)))...((....))..((((.....))))......)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)<)))...(((.(((((.......A))))))))..).))))))))).(.(((....[)))...).]))))))......).))..((((((....(((((....)))))((((((((....((((((((((.....(((...((((((((...()...))))))))..)).).....))))).)))).).)))))).))..(((((((.((......)).)))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((..(((.........)))..))).....(...((......)).).)))))...)))))))))).))...........]]].)...))))))))))...)))))))(((((((())))))))....))))))(.(((((((.((......(((((.((....))])))))...)).)))))))..).....))))))(......((....((((((.......))))))((((....(((...((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]]((((((((.((......((...(((((...((((..(((..(((((.(((((....{{....))))).((..(((((..((((.((((((.((.....))))))))......))))..)))))...))....().....)))))...)))...))))(..)....)))))..))..)).)))))))))))).))).....((......))..))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))(((((....((((....))))...)))))(...).......(((((((((.>.((.........))...(((((((.....(((....)))..[....))))))).}((((.(((..(((((((..(((...((...(((((..((....))...)))))...))...))))))))..)))))((((((.......))))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).[..(((((.....>].)))))..((((((((.(((.((......((((.((((((..(((((.(((((((((.(((((.((((((.((..(......[..(((((..(((.......(((.(((....))).)))....)))..........].))))))..)).)))))).)))))....((.((((((...].)))))))).....)))))))))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..a.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..((((....))))....(((.(((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))....)))....))))))). Cryo-EM structure of the Listeria innocua 50S ribosomal subunit in complex with HflXr (structure III); 23S Ribosomal RNA 8uua B 114 2.7 RF00001 URS0002311A24_169963 38407413 0003735 0005840 1642 cugguaguuauggcgagaaggucacacccguucccaucccgaacacgguaguuaagcuucucugcgccaaugguaguugggggcuucccccugcgagaguaggucgcugccggg <<<<<<<<....<<<<<<<<.....<<<<<<.............>>>>..>>....>>>>>>.>><<<.......<<.<<<<<...>>>>>.>>.......>>>.>>>>>>>>. ((((((((....((((((((.....(..(((...(.....)...)))....)....)))))).))(((.......((.(((((...))))).)).......))).)))))))). Cryo-EM structure of the Listeria innocua 50S ribosomal subunit in complex with HflXr (structure III); 5S Ribosomal RNA 8uvr 1A 2871 2.6 RF02541 38165935 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<....<<<..........>>..>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<..<<<<.......>>>...>>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<.......<<<<.<......>.>>>>....>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<...>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((..(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((.(..(((..........)..)))..)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((..((.........))...))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(......[..(((((..(((......((((((((....))))))))...)))..........].)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..(((...)))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with spectinomycin, mRNA, deacylated A- and E-site tRNAphe, and deacylated P-site tRNAmet at 2.60A resolution; 23S Ribosomal RNA 8uvr 1B 120 2.6 RF00001 38165935 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> (((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).))))))))))) Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with spectinomycin, mRNA, deacylated A- and E-site tRNAphe, and deacylated P-site tRNAmet at 2.60A resolution; 5S Ribosomal RNA 8uvr 1a 1500 2.6 RF00177,RF01959,RF02542,RF01960 38165935 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<......>>....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((..)))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((((((....)))))))....(((....)))....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with spectinomycin, mRNA, deacylated A- and E-site tRNAphe, and deacylated P-site tRNAmet at 2.60A resolution; 16S Ribosomal RNA 8uvr 1v 13 2.6 38165935 10665 aaaaauguucuaa ............. ............. Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with spectinomycin, mRNA, deacylated A- and E-site tRNAphe, and deacylated P-site tRNAmet at 2.60A resolution; MF-mRNA 8uvr 1w 74 2.6 RF00005 38165935 0030533 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[..)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with spectinomycin, mRNA, deacylated A- and E-site tRNAphe, and deacylated P-site tRNAmet at 2.60A resolution; A-site and E-site Deacylated tRNAphe 8uvr 1x 76 2.6 RF00005 38165935 0030533 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with spectinomycin, mRNA, deacylated A- and E-site tRNAphe, and deacylated P-site tRNAmet at 2.60A resolution; P-site Deacylated tRNAmet 8uvr 1y 74 2.6 RF00005 38165935 0030533 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[..)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with spectinomycin, mRNA, deacylated A- and E-site tRNAphe, and deacylated P-site tRNAmet at 2.60A resolution; A-site and E-site Deacylated tRNAphe 8uvr 2A 2800 2.6 RF02541 38165935 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>..<....<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<............>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<..>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>>.<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....(())....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.(((.....((............).).....))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((((((()))))))))).))..........]]].)....))))))))))...)))))))(((((((())))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........(((((..(((......((((((((....))))))))...)))............)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))..(...)......(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with spectinomycin, mRNA, deacylated A- and E-site tRNAphe, and deacylated P-site tRNAmet at 2.60A resolution; 23S Ribosomal RNA 8uvr 2B 120 2.6 RF00001 38165935 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> .(((((((.((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)).))))))). Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with spectinomycin, mRNA, deacylated A- and E-site tRNAphe, and deacylated P-site tRNAmet at 2.60A resolution; 5S Ribosomal RNA 8uvr 2a 1503 2.6 RF00177,RF01959,RF02542,RF01960 38165935 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggau .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<......>>....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((...(((((((....)))))))....(((....)))....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((..(((.(.((....)).)).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with spectinomycin, mRNA, deacylated A- and E-site tRNAphe, and deacylated P-site tRNAmet at 2.60A resolution; 16S Ribosomal RNA 8uvr 2v 13 2.6 38165935 10665 aaaaauguucuaa ............. ............. Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with spectinomycin, mRNA, deacylated A- and E-site tRNAphe, and deacylated P-site tRNAmet at 2.60A resolution; MF-mRNA 8uvr 2w 72 2.6 RF00005 URS00005AA258_562 38165935 0030533 0006412 562 cccgganagcucagggagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<..<<<<.....>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((...[.)))).((((.........)))).....(((((..]....)))))))))))..... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with spectinomycin, mRNA, deacylated A- and E-site tRNAphe, and deacylated P-site tRNAmet at 2.60A resolution; A-site and E-site Deacylated tRNAphe 8uvr 2x 76 2.6 RF00005 38165935 0030533 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with spectinomycin, mRNA, deacylated A- and E-site tRNAphe, and deacylated P-site tRNAmet at 2.60A resolution; P-site Deacylated tRNAmet 8uvr 2y 73 2.6 RF00005 38165935 0030533 562 gcccgganagcucagggagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<.....>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[.)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with spectinomycin, mRNA, deacylated A- and E-site tRNAphe, and deacylated P-site tRNAmet at 2.60A resolution; A-site and E-site Deacylated tRNAphe 8uvs 1A 2871 2.75 RF02541 38165935 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<....<<<<........>>>..>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..<<<.......>>>...>>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<.......<<<<<<......>>>>>>....>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<...>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((..(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((.(..(((..........)..)))..)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((..((.........))...))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(......[..(((((..(((......((((((((....))))))))...)))..........].)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..(((...)))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with spectinomycin derivative 2694, mRNA, deacylated A- and E-site tRNAphe, and deacylated P-site tRNAmet at 2.75A resolution; 23S Ribosomal RNA 8uvs 1B 120 2.75 RF00001 38165935 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> (((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).))))))))))) Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with spectinomycin derivative 2694, mRNA, deacylated A- and E-site tRNAphe, and deacylated P-site tRNAmet at 2.75A resolution; 5S Ribosomal RNA 8uvs 1a 1500 2.75 RF00177,RF01959,RF02542,RF01960 38165935 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<......>>....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((((((....))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((..((((....))))..))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((((((....)))))))....(((....)))....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with spectinomycin derivative 2694, mRNA, deacylated A- and E-site tRNAphe, and deacylated P-site tRNAmet at 2.75A resolution; 16S Ribosomal RNA 8uvs 1v 13 2.75 38165935 10665 aaaaauguucuaa ............. ............. Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with spectinomycin derivative 2694, mRNA, deacylated A- and E-site tRNAphe, and deacylated P-site tRNAmet at 2.75A resolution; MF-mRNA 8uvs 1w 74 2.75 RF00005 38165935 0030533 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[..)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with spectinomycin derivative 2694, mRNA, deacylated A- and E-site tRNAphe, and deacylated P-site tRNAmet at 2.75A resolution; A-site and E-site Deacylated tRNAphe 8uvs 1x 76 2.75 RF00005 38165935 0030533 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with spectinomycin derivative 2694, mRNA, deacylated A- and E-site tRNAphe, and deacylated P-site tRNAmet at 2.75A resolution; P-site Deacylated tRNAmet 8uvs 1y 74 2.75 RF00005 38165935 0030533 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((......)))).((((.........)))).....(((((.......)))))))))))).... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with spectinomycin derivative 2694, mRNA, deacylated A- and E-site tRNAphe, and deacylated P-site tRNAmet at 2.75A resolution; A-site and E-site Deacylated tRNAphe 8uvs 2A 2800 2.75 RF02541 38165935 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<............>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<..>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<..>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<.......<<<<<<<<....>>>>>>>>....>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((()))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((....(...............)....)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((.().)))))))).))..........]]].)....))))))))))...)))))))(((((((())))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(......[..(((((..((.......((((((((....))))))))....))..........].)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))..(...)......(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with spectinomycin derivative 2694, mRNA, deacylated A- and E-site tRNAphe, and deacylated P-site tRNAmet at 2.75A resolution; 23S Ribosomal RNA 8uvs 2B 120 2.75 RF00001 38165935 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>>. .(((((((.((....((((((.(....(((((((...(.....)...))))..)))...).)))).))(((.......((((((((....)))))))).......))).)).))))))). Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with spectinomycin derivative 2694, mRNA, deacylated A- and E-site tRNAphe, and deacylated P-site tRNAmet at 2.75A resolution; 5S Ribosomal RNA 8uvs 2a 1503 2.75 RF00177,RF01959,RF02542,RF01960 38165935 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggau .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<............>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>..>>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<......>>....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((.(((((...))))).))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((((((....))))))).(..(.(....).)..).)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.(.((....)).)).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with spectinomycin derivative 2694, mRNA, deacylated A- and E-site tRNAphe, and deacylated P-site tRNAmet at 2.75A resolution; 16S Ribosomal RNA 8uvs 2v 13 2.75 38165935 10665 aaaaauguucuaa ............. ............. Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with spectinomycin derivative 2694, mRNA, deacylated A- and E-site tRNAphe, and deacylated P-site tRNAmet at 2.75A resolution; MF-mRNA 8uvs 2w 72 2.75 RF00005 URS00005AA258_562 38165935 0030533 0006412 562 cccgganagcucagggagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<..<<<<.....>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((...[.)))).((((.........)))).....(((((..]....)))))))))))..... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with spectinomycin derivative 2694, mRNA, deacylated A- and E-site tRNAphe, and deacylated P-site tRNAmet at 2.75A resolution; A-site and E-site Deacylated tRNAphe 8uvs 2x 76 2.75 RF00005 38165935 0030533 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with spectinomycin derivative 2694, mRNA, deacylated A- and E-site tRNAphe, and deacylated P-site tRNAmet at 2.75A resolution; P-site Deacylated tRNAmet 8uvs 2y 73 2.75 RF00005 38165935 0030533 562 gcccgganagcucagggagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<.....>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[.)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with spectinomycin derivative 2694, mRNA, deacylated A- and E-site tRNAphe, and deacylated P-site tRNAmet at 2.75A resolution; A-site and E-site Deacylated tRNAphe 8v83 1 2015 2.53 RF02543 38632236 0003735 0005840 1247190 guuugaccucaaaucagguaggaguacccgcugaacaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaugguguuuugugcccucugcuccuuguggguaggggaaucucgcauuucacugggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaaggguauaggggcaagacaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuagaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugaggaacagccucuaguugauagaauaauguagauauaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauagaggguguagaauaagugggagcuucggcgccagugaaauaccacuaccuuuauaguuucuuuacuauugucagguggggaguaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuugauucucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucaccgggaacgugagcugggucgucgugagacaggccuacugaguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugaugcuccacacagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ..........................<<<<<<........>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..<<<..<........<<.<<<<<<...>>>>>>.>>........>....<<<<<<<.<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<..>>>>>>>.....<<<<<<......>>>>>>..>>>..................................<<....>>...............<<<......>>>..................................<<<<<.<<<<<<.....<<<<...<<<..<<<<<<<<<.....>>>>>>>>>......>>>...>>>>..<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<......>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>..................<<<<<..<<<<<....>>>>>...>>>>>....<.<<<.......>>>..>........>>>>>>.>>>>>>..<<.<...<<<<<<....<<<<<<<...>>>>>>>...<.....>>>>>>>......>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<..>>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<......<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>....>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>>..<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<......<<<<..<<.........>>...>>>><<<<..<..<<<<<<..>>>>>>>.>>>>>>....>>.(.<<<<<<......).>>>>>>....<<<<..<<<........<<<<<<.<<<<<<..<<<<.<<<<<<<....<.<<<<<<<<<<<<.<<.........<<<<<..<<....>>............>>>>>.>>>>>>>.>>>>>>>.>.....>>>>>>>..>>>>..>>>>>.>.>>>>>>..............<<<<<...<<.......>>...>>>>>........<<<<<<..<<.....<<<<<<<......>>>>>>>......>>...<<<<.<..>>>>>..>>>>>>...<<<<....>>>.>.>>>.>>>>.<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<.....<<<<<<<<<<<<<<<....>>>>>..>>>>>>>>>.>...>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>..<<<..<......<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>............>.>>>..<<<<<<.<.............>.....<<<<<<<<<.<<<.....<<<.......<........>......>>>....>>>....>>>>.>>>>>..>>>>>>. ..........................(((((..........)))).).........((....))...((((......((.....)).....))))...((((.........(((.((((((...)))))).))....)........(((((((.((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))))....)))))))))))...)....(((((((..))))))).....((((((......))))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....((((...((((.((((((((((..).))))))))).....))))...))))..(((((((((((((((((((((((.......(((((((......(((((......))))).......))))))).....))))).))))))))))........((......))....))))))))....)))))).)))))..((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))..................(((((..(((((....)))))...)))))..(....((.......))....).......)))))).))))))..((.(...((((((...(.((.((.....)).)).)..(.....)))))))......).))).((((((......(((....)))..((((((((((...(((.(((..)))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((....[.(....{.....(((.((((((((((.....<.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))......]...]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((......((((..(.(......)..)...))))((((.....(((((.().)))))..))))))....)).[.((((((......].))))))....((((...((........((((((.((((((..(((..(..((((...((...(((.((.(((.((..........((((..((....))............))))..))))).).).)))...))....))))..)...)))..))))).).))))))......}......((((((...((.......))...)))))).......((((((..((.....(((((((......)))))))......))...((((.(())))))..))))))...((((....))).).))..)))).(((((((..((((.(.(((((......(....).....))))).)(((((.....(.((((((((((((......))))..))))))))..)...))))).((((...((((.....>.......))))...)))).))))....)))))))..(((.........((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).))))))..............)))..((((((.(..(.......)..)...(.(((..((((.(((....(.((.........(..)..........)).)...)))....))))...)))).)))))). 60S ribosome biogenesis intermediate (Dbp10 pre-catalytic structure - Overall map); Saccharomyces cerevisiae S288C 25S ribosomal RNA 8v83 2 150 2.53 RF00002 38632236 0003735 0005840 1247190 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacgcgccccuuggcagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<..>><<<<<<<.<>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((..))(((((((.())))))))..................... 60S ribosome biogenesis intermediate (Dbp10 pre-catalytic structure - Overall map); Saccharomyces cerevisiae S288C 5.8S ribosomal RNA 8v83 6 58 2.53 38632236 1247190 ccuucucaaacauguuugguagugagugauacucgaguuaacuugaaauugccuuaaa ......<<<<<..>>>>>.....<<<<.<.<<<..>>>>.>>>>.............. .......((((())))).....(((((.(.(((())))).))))..)........... 60S ribosome biogenesis intermediate (Dbp10 pre-catalytic structure - Overall map); Saccharomyces cerevisiae ITS-2 8v84 1 1970 2.7 RF02543 38632236 0003735 0005840 1247190 guuugaccucaaaucagguaggaguacccgcugaacaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaugguguuuugugcccucugcuccuuguggguaggggaaucucgcauuucacugggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaaggguauaggggcaagacaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuagaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugaggaacagccucuaguugauagaauaauguagauauaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauagaggguguagaauaagugggagcuucggcgccagugaaauaccacuaccuuuauaguuucuuuacuauugucagguggggaguaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuugauucuauaccgaagcagaauucgguaagccgucgugagacaggccuacugaguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugaugcuccacacagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ..........................<<<<<<........>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..<<<...........<<.<<<<<<...>>>>>>.>>.............<<<<<<<.<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<..>>>>>>>.....<<<<<<......>>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<<.....<<<<...<<<..<<<<<<<<<.....>>>>>>>>>......>>>...>>>>..<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<......>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>..................<<<<<..<<<<<....>>>>>...>>>>>....<.<<<.......>>>..>........>>>>>>.>>>>>>..<<.<...<<<<<<...<<<<<<<<...>>>>>>>>..<.....>>>>>>>......>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<..>>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<......<<<<..<<.........>>...>>>><<<<...<.<<<<<<..>>>>>>>.>>>>>>....>>...<<<<<<........>>>>>>....<<<<..<<<........<<<<<<.<<<<<<..<<<<..<<<<<<....<..<<<<<<<<<<<.<<..........<<<<..<<<..>>>............>>>>..>>>>>>>.>>>>>>..>.....>>>>>>...>>>>..>>>>>.>.>>>>>>..............<<<<<...<<.......>>...>>>>>.........<<<<<<<......>>>>>>>....<<<....>>>...>>>.>>>>.<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<..<.<.<....<<<<<<<<<<....>>>>>..>>>>>...>.>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>..<<<..<......<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>............>.>>>..<<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<.....<.<........>.>....>>>>...>>>....>>>>.>>>>>..>>>>>>. ..........................(((((..........)))).).........((....))...((((......((.....)).....))))...((((.........(((.((((((...)))))).))....)........(((((((.(((((((((((.((((((((...({((((......)))))[[(...).(((....}]])))....))))))))...)))))))....)))))))))))...)....(((((((..))))))).....((((((......))))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((.....((((...((((.((((((((((..).))))))))).....))))...))))..(((((((((((((((((((((((.......(((((((......((((........)))).......))))))).....))))).))))))))))........((......))....))))))))....)))))).)))))..((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))..................(((((..(((((....)))))...)))))..(....((.......))....).......)))))).))))))..((.(...((((((...(.((.((.....)).)).)..(.....)))))))......).))).((((((......(((....)))..((((((((((...(((.(((..)))))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((....[.(....{.....(((.((((((((((.....<.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))......]...]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((......((((..(((......).))...))))((((.....((((.(()).))))..))))))....)).[.((((((......].))))))....((((...((........((((((.((.(((..(((.....((((...((...((.(((.(((.((..........((((..((....))............))))..))))).).)).))...))....))))......)))..))).).).))))))......}.......(((((...((.......))...))))).........((((((........))))))...((((....))).).))..)))).(((((((..((((.(.(((((......(....).....))))).)(((((..(........(((((((.(......).))..)))))......)..))))).((((...((((.....>.......))))...)))).))))....)))))))..(((.........((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).))))))..............)))..((((((.(..(.......)..)...(.((((.((((.(((....(.((........((..)..).......)).)...)))....))))..))))).)))))). 60S ribosome biogenesis intermediate (Dbp10 catalytic structure - Overall map); Saccharomyces cerevisiae 25S ribosomal RNA 8v84 2 150 2.7 RF00002 38632236 0003735 0005840 1247190 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacgcgccccuuggcagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<..>><<<<<<<.<>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((..))(((((((.())))))))..................... 60S ribosome biogenesis intermediate (Dbp10 catalytic structure - Overall map); Saccharomyces cerevisiae 5.8S ribosomal RNA 8v84 6 58 2.7 38632236 1247190 ccuucucaaacauguuugguagugagugauacucgaguuaacuugaaauugccuuaaa ......<<<<<..>>>>>.....<<<<.<.<<<..>>>>.>>>>.............. .......((((())))).....(((((...(((())))..))))..)........... 60S ribosome biogenesis intermediate (Dbp10 catalytic structure - Overall map); ITS2 RNA 8v87 1 2489 2.66 RF02543 38632236 0003735 0005840 1247190 guuugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacauggugcacugggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucgcgguucgaucgucgaauuuggguauaggggcgaaagacuaaaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugaauguaaaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugaucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggggggaaucuggagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauagaggguguagaauaagugggagcuucggcgccagugaaauaccacuaccuuuauaguuucuuuacuauugucagguggggaguaaaguuaccacagggauaacuggcuuguggcagucaagcgagcgacauugcuuuuugagaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccguuacgaucugcugagauuaagccuuuguugucugauuugu ..........................<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..<<<...........<<.<<<<<<...>>>>>>.>>.............<<<<<<<.<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....<<<<<<..>>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<.....<<<<..>>>>.<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<......>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<.<....>.>>>><<<<<<...<<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<...>>....>>>>>>.>>>>>>>.<<.<..<<<<<<<...<<<<<<<<<<...<<<....<<<<<<<....>>>>>>>.....>>>.<<.......>>......>>>>>>>>>>.<<<....>.>>...>>>>>>>.....>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<....>>>>>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<.......<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<<....<<..<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<........>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<......<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..(((..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>............>>.>>>>>>>>>>>>..>>..>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<<<<<<....<<<<<<<<..>>>>>>>>>>>.>>>>>>>>>>>..>>>>>>...>>>....<<<<<........>>>>>....<<<<<..<<<........<<<<<<.<<<<<<.<<<<<.<<<<<<<....<.<<<<<<<<<<<<.<<..........<<<<..<<<..>>>............>>>>..>>>>>>>.>>>>>>>.>.....>>>>>>>..>>>>>.>>>>>.>.>>>>>>.............<<<<<<...<<..>>...>>>>>>......((..<<<<<<.<<<<<..<.<<<<<<<......>>>>>>>...>..<<.....))..>>......>>>>>.....>>>>>>.....<<<<<<<....>>>.>>>>........>>>.>>>>>....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<...<<<<<<<<<<<))).>>>>>..>>>>>>..>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<.<..<<.......>>..>>>>>...>>>....>>>>.>>>>>..>>>>>.. ..........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........(((((((.((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))))....)))))))))))...)....(((((((........))))))).....((((((..))))))..)))..................................((....))............(..((((....))))............).....................(((((.(((((......(((())))..(((((((((((((((((((((((.......(((((((......((((..(..)..)))).......))))))).....))))).))))))))))........(((....)))....)))))))).....))))).)))))..((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((().))....)))))).))))))..((.(...((((((...((.(((((((...((((...(((((((....)))))))...).))).((..(..).))......))))))).)).(.(....)..)...))))))......).))).((((((......(((....)))..((((((((((...(((.(((((((..)))))))))).)))))))).))..((((.((.((.....)).)).))))....(((......)))...(((((((...((([[[...(.((((((......(.......(((.((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((....)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((..((((((.......))))))((((.....(((((.((...((((((...((.....)).))))))....[[(((.((...((....(((....)))........((((((........))))))....))....))...(((((........)))))]]((((..(((((.....((((....)))...(...((((((...((((.((((((((((((((((((..[[[..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...)).......)).))).)))).)))..))..))))).((((.....))))..))))..((((.....(((((((.(((((((....((((((((..))))))))))).)))))))))))..))))))....)).[..(((((......].)))))....(((((...((........((((((.((((((..((((.(((((((...(....(((.((((((.((......[...((((..((....))..........].))))..))))))).).)))....)....)))))))..))))..))))).).)))))).............((((((...((..))...))))))......[[...(((((.(((((..(.(((((((......))))))..).).(.(.....]]..).).....))))).(..)))))).......((.(((....)))..)).........))..)))))....((((((((..((((.(..((((......(....).....))))..)(((((...((((....((((((((((]]].)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((.......))..)))))...)))....)))).)))))).))))).. 60S ribosome biogenesis intermediate (Dbp10 post-catalytic structure - Overall map); 25S ribosomal RNA 8v87 2 155 2.66 RF00002 URS00001BF64E_559292 38632236 0003735 0005840 1247190 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacgcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<..>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((..))(((((((((....)))))))))..................... 60S ribosome biogenesis intermediate (Dbp10 post-catalytic structure - Overall map); 5.8S ribosomal RNA 8v87 6 87 2.66 38632236 1247190 ccuucucaaacauucuguuugguagugagugauacucuuuggaguuaacuugaaauugcuggccuuuaggcgaacaauguucuuaaa ......<<<<<<...>>>>>>.....<<<<.<.<<<<....>>>>>.>>>>..........<<<<..>>>>................ ......((((((...))))))....(((((...((((....))))..))))..).......((((..))))................ 60S ribosome biogenesis intermediate (Dbp10 post-catalytic structure - Overall map); ITS2 RNA 8v9j a 1511 3.1 RF00177,RF01959,RF02542,RF01960 URS00001AF2F7_246196 38355796 0003735 0005840 246196 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......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<..<<<<<<<....>>>>>.>>>..>>>>>......<<........<<<<<<<..<<...<<<<<<<<<<<<.....<<<<<......>>>>>......>>>>.....<<<<<<<<<<<....>>>>.>>>>>>>....<<....>>>>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<<....>>.......>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<.....<<<<<<<.....>>>>>>>...>>>>>>>..>>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<<..<<<......>>>.....>>>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<.......>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<.......<<<<<<...<<<<<<<....>>>>>>>.<<.....>>.>>>>>>..<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<<..<<<......>>>>>.....>>>>>>.....<<<<<.....>>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>......>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<..<<<<....<.<<<<..<<<..<<.....>>.>>>.>>>>.>...>>>>..>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... ......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(.(((......)))..)))..)))))......(((.......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....((((((.((((....))))..))))))....((....)).)))))))..))))))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(..((....))..)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((.....(((((((.....)))))))...))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((.(.......).))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((((..((((.((....)).))))..(.....).))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((.(...((..(((......)))))....).)))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...((((((......(((..((...(((....)))...))....))).......))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((..((((....(.((((..(((..((.....)).))).)))).)...))))..))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Cryo-EM structure of the Mycobacterium smegmatis 70S ribosome in complex with hibernation factor Msmeg1130 (Balon) (Structure 4); 16S Ribosomal RNA 8v9j y 74 3.1 RF00005 URS00005AA258_246196 38355796 0030533 0006412 246196 gcccgganagcucaggguagagcaggggauugaaaauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[..)))).((((.........)))).....((.((..]....)).))))))))).... Cryo-EM structure of the Mycobacterium smegmatis 70S ribosome in complex with hibernation factor Msmeg1130 (Balon) (Structure 4); pe/E deacylated phenylanaline-tRNA 8v9j A 3073 3.1 RF02541 URS00003A7753_246196 38355796 0003735 0005840 246196 aaguguuuaagggcgcaugguggaugccuuggcacugggagccgaugaaggacguaggaggcugcgauaagccucggggagcugucaaccgagcguugauccgaggauguccgaauggggaaacccggcacgagugaugucgugucaccaggcgcugaauauauaggcgucuggggggaacgcggggaagugaaacaucucaguacccguaggaagagaaaacaaaaugugauuccgugaguaguggcgagcgaaagcggaggauggcuaaaccguaugcaugugauaccggguagggguugugugugcgggguugugggaccuaucuuuccggcucuaccuggcuggagggcagugagaaaauguugugguuagcggaaauggcuugggauggccugccguagacggugagagcccgguacgugaaaacccgacgucugucuugaugguguucccgaguagcagcgggcccguggaaucugcugugaaucugccgggaccacccgguaagccugaauacuucccagugaccgauagcggauuaguaccgugagggaauggugaaaaguaccccgggaggggagugaaagaguaccugaaaccgugcgcuuacaauccgucagagcccucgacgugucguggggugauggcgugccuuuugaagaaugagccugcgagucagggacaugucgcgagguuaacccgggugggguagccgcagcgaaagcgagucugaauagggcguauccacacaagagugugugguguagugguguguucuggacccgaagcggagugaucuacccauggccagggugaagcgcggguaagaccgcguggaggcccgaacccacuuagguugaagacugaggggaugagcuguggguaggggugaaaggccaaucaaacuccgugauagcugguucuccccgaaaugcauuuaggugcagcgucgcauguuucuugccggagguagagcuacuggauggccgaugggccccacaggguuacugacgucagccaaacuccgaaugccgguaaguccaagagugcggcagugggacggcgggggauaagcuccgugcgucgagagggaaacagcccagaucgccggcuaaggccccuaagcgugugcuaaguggaaaaggaugugcagucgcgaagacaaccaggagguuggcuuagaagcagccacccuugaaagagugcguaauagcucacuggucaagugauugugcgccgauaauguagcggggcucaagcacaccgccgaagccgcggcagccaacguguuggcuggguaggggagcguccugcauccggugaagccgccgagugaucgagugguggagggugugggagugagaaugcaggcaugaguagcgauuaggcaagugagaaccuugcccgccgaaagaccaaggguuccugggccaggccaguccgcccagggugagucgggaccuaaggcgaggccgacaggcguagucgauggacaacggguugauauucccguacccguguaugugcguccaugaugaaucagcgguacuaaccauccgcaugggaccuucguugguaguagucaagcgauggggugacgcaggaagguagccguaccggucagugguaauaccgggguaagccuguagggagucagauagguaaauccgucuggcauauauccugagaggugaugcauagccgagugaggcgaauucggugauccuaugcugccgagaaaagccucuagcgaggacauacacggcccguaccccaaaccaacacagguggucagguagagaauacuaaggcguacgagugaacuaugguuaaggaacucggcaaaaugcccccguaacuucgggagaagggggacccacauggcguguaagccuuuacggcccaagcgugaguggguggcacaaaccagugagaagcgacuguuuacuaaaaacacagguccgugcgaagucgcaagacgauguauacggacugacgccugcccggugcuggaagguuaagaggacccguuaacucccuuugggggugaagcggagaauuuaagccccaguaaacggcggugguaacuauaaccauccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaacgacuucucaacugucucaaccauagacucggcgaaauugcacuacgaguaaagaugcucguuacgcgcggcaggacgaaaagaccccgggaccuucacuacaacuugguauuggugcucgauacgguuuguguaggauaggugggagacugugaagcucacacgccaguguggguggagucguuguugaaauaccacucugaucguauugggccucuaaccucggaccguauauccgguucagggacagugccugguggguaguuuaacuggggcgguugccuccuaaaauguaacggaggcgcccaaagguucccucaaccuggacggcaaucagguguugaguguaagugcacaagggagcuugacugcgagacggacaugucgagcagggacgaaagucgggacuagugauccggcaccucugaguggaaggggugucgcucaacggauaaaagguaccccggggauaacaggcugaucuuccccaagaguccauaucgacgggaugguuuggcaccucgaugucggcucgucgcauccuggggcuggagcaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguuuagaacgucgugagacaguucggucucuauccgccgcgcgcgucagaagcuugaggaaaccugucccuaguacgagaggaccgggacggacgaaccucugguauaccaguugucccaccaggggcacggcuggauagccacguucggacaggauaaccgcugaaagcaucuaagcgggaaaccucuuccaagaccaggcuucucacccucuaggagggauaaggccccccgcagaccacgggauugauagaccagaccuggaagccuaguaauaggugcagggaacuggcacuaaccggccgaaaacuuac <<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<<......<<<<<<.[[.(((.>>>.....<<<<<<<..<<<)))..]].>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<.....>>..<<<<<<.....<<.....>>....>>>>>>...<<<....<<<<<<<<<<.........<<<<<.....>>>>>>>>>>......<<<<..[.....<<<<<<.>>>>>..>>>>>><<<<<<.......<<<<<<.<<<<.<<<.....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>>>.....]...>>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..>>>......>>.>>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<<<<..>>>>.>>>>>..>>>>...<.<........>.>.<<<<<<....<<<.<<<<<<<<<<..<<<...<<<....>>>...>>>...<<....>>..<<<<.....>>>>....<<<<<<<....>>>>>>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<....<<<<<<<<.....<<<....<<<.<<<<....<<<<<......>>>>.>....>>>>.>>>..>>.>.....>>>>>>>>.......>>>>>>>.>>..<<<<<<<<<<......>>>>>>.>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..<<<<.......>>>>..>>>.........<<......>>...>>>>>....>>>>>>>>>.>>...........)))......>>>>>>.>>>...>>>>>>><<<<<<<<..>>>>>>>>....>>>>>><.<<<<<<<<<<......<<<<<<<<....>>>.>>>>>...>>>>>>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<.......<<<<...<<<<<<<......<<<<....>>>>.....>>>>>>>.....>>>>.<<...<<<<<...<<<<..<<<..<<<<..<<<<<...((((...>>>>>.<<..<<<<...<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>...>>>>...>>...<<<......>>>.....>>>>...>>>...>>>>........>>>>>..>>....>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<<...<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<...<<<<....<<<.....>>>....>>>>..>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.<<<....<<<<<.<<<<<<...>>>>>>..>>>>>....>>>.>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>>>>>>>>.....>.((..<<<<<......))>>>>>..<<<<<<<<.<<<.<<......<<<<<<<<<<..<<<<<.<<<.<<<<<.<<.<<<<<<<<<<<<<...........<<<<<...........<<<<<<<<....>>>>>>>>..................>>>>>..>>>>>>>>>>>>>.>>...<<<.<<<<<<......>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.<<..>>>>..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<.<<<<...<<.......>>...>>>>.>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))))>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<...>>>>>....<<<<.<<<<.......>>>>.....<<<.<<<<.<<<....<<<<<....>>>>>...>>>..>>>>..>>>...>>>>....>>>>.. ((((......((((((((((.....(((..(((((((((((((......((((((.[[.[[[.))).....((((((...(((]]]..]].)))......))))))...)))....(((....)))(((((((......))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))....((([...((((((((((........[[[[[[.....))))))))))....(.((((.((.....((((((.]]]]]].)))))).(((((.......((((((.((((.(((...(.((((......)))))[[(...).(((.....]])))...)))...)))))))))))))))......).).))))]....(((((((...[.......)))))))....).(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((..(((((((((..)))).)))))..)))).<.(.(........).).((((((..(.(((.((((((((((..(((...(((....)))...)))...((....))..((((.....))))....(((((((....)))))))....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......A))))))))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))(((((((((.([.((((((((.....(((....(((.((((....(((((......)))).)....)))).)))..)).).....))))))))....).]))))))).))..((((((((((......)))))).))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((.((((.....{.(((((.((([.(((.........)))..))).....(]..((......)).).)))))...)))).))))).))...........]]].)....))))))))))...)))))))((((((((..))))))))....))))))(.((((((((((......((((((((....))).)))))...))))))))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]]((((((((((.(.....(((...(.((.((.......((((.().))))......)).)).).....))).((...(((((...((((..(((..((((..(((((....{{....))))).((..(((....(((((((((((.((.....))))))))).....))))..[.)))...))...(((......))).....))))...)))...))))(..)....)))))..))..).)))))))))))))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((...((((....((((..)])))....))))..))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((....((((..((((((...))))))...))))....))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....))[[..(((((.....>]])))))..((((((((.(((.((......((((((((((..(((((.(((.(((((.((.((((.(((((((..(.........(((((...(........(((((((....))))))).....).............))))))..))))))).)))).))...(((.((((((......)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.(.((((...((.......))...)))).)...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..a.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..(((((...)))))....((((.((((.......)))).....(((.((((.(((....(((((....)))))...)))..))))..)))...))))....)))).. Cryo-EM structure of the Mycobacterium smegmatis 70S ribosome in complex with hibernation factor Msmeg1130 (Balon) (Structure 4); 23S Ribosomal RNA 8v9j B 118 3.1 RF00001 URS00000ACC0A_246196 38355796 0003735 0005840 246196 guuacggcgguccauagcggcagggaaacgcccggucccaucccgaacccggaagcuaagccugccagcgccgaugauacuacccauccggguggaaaaguaggacaccgccgaacac <<<.<<<<<<<.....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<.......<<<<<<....>>>>>>.......>>..>>>>>>>>>>.. (((.(((((((.....((((((((.....((((((...(.....)...))))..))....)))))).)).((.......((((((....)))))).......))..)))))))))).. Cryo-EM structure of the Mycobacterium smegmatis 70S ribosome in complex with hibernation factor Msmeg1130 (Balon) (Structure 4); 5S Ribosomal RNA 8v9k a 1511 3.1 RF00177,RF01959,RF02542,RF01960 URS00001AF2F7_246196 38355796 0003735 0005840 246196 uuuggagaguuugauccuggcucaggacgaacgcuggcggcgugcuuaacacaugcaagucgaacggaaaggcccuuucggggguacucgaguggcgaacgggugaguaacacgugggugaucugcccugcacuuugggauaagccugggaaacugggucuaauaccgaauacacccugcuggucgcauggccugguaggggaaagcuuuugcggugugggaugggcccgcggccuaucagcuuguugguggggugauggccuaccaaggcgacgacggguagccggccugagagggugaccggccacacugggacugagauacggcccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagcgacgccgcgugagggaugacggccuucggguuguaaaccucuuucagcacagacgaagcgcaagugacgguaugugcagaagaaggaccggccaacuacgugccagcagccgcgguaauacguaggguccgagcguuguccggaauuacugggcguaaagagcucguaggugguuugucgcguuguucgugaaaacucacagcuuaacugugggcgugcgggcgauacgggcagacuagaguacugcaggggagacuggaauuccugguguagcgguggaaugcgcagauaucaggaggaacaccgguggcgaaggcgggucucugggcaguaacugacgcugaggagcgaaagcguggggagcgaacaggauuagauacccugguaguccacgccguaaacgguggguacuagguguggguuuccuuccuugggauccgugccguagcuaacgcauuaaguaccccgccuggggaguacggccgcaaggcuaaaacucaaaggaauugacgggggcccgcacaagcggcggagcauguggauuaauucgaugcaacgcgaagaaccuuaccuggguuugacaugcacaggacgccggcagagaugucgguucccuuguggccugugugcagguggugcauggcugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuugucucauguugccagcacguuaugguggggacucgugagagacugccggggucaacucggaggaagguggggaugacgucaagucaucaugccccuuauguccagggcuucacacaugcuacaauggccgguacaaagggcugcgaugccgugagguggagcgaauccuuucaaagccggucucaguucggaucggggucugcaacucgaccccgugaagucggagucgcuaguaaucgcagaucagcaacgcugcggugaauacguucccgggccuuguacacaccgcccgucacgucaugaaagucgguaacacccgaagccgguggccuaacccuuguggagggagccgucgaaggugggaucggcgauugggacgaagucguaacaagguagccguaccggaaggugcggcuggauc ......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<......<<<.<<<..<<<..<<.<....<<<<<....>>>>>...>..>>>>>......<<........<<<<<<<..<<...<<<<<<<<<<<<.....<<<<<<....>>>>>>......>>>>.....<<<<<<<<<<<<..>>>>>.>>>>>>>....<<....>>>>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<............>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>...>.>>>>>>..<<<<.......<<<....>>>......>>>>...<.<<<<<......<......>.......>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<.....<<<<<<<.....>>>>>>>...>>>>>>>..>>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<<..<<<......>>>.....>>>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<.......>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>.<<.....>>.>>>>>>>.<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<<..<<<......>>>>>.....>>>>>>.....<<<<.......>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>......>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<..<<<<....<.<<<<..<<<..<<.....>>.>>>.>>>>.>...>>>>..>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... ......((((..[.[[[..)))).((((.(((((..((((((.((....(((.(((..(((..((.((..(.(((......)))..)))..)))))......(((.......(((((((..((...((((((((((((......((.((....)).)).......)))).....((((((.((((....))))..))))))....((....))))))))))..))))))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((.....(((....)))...)))).)..))))))..((((........((....)).......))))...(.(((((...(...(....)...)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((.....(((((((.....)))))))...))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((.(.......).))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........((((((.(.(...((((((((..(((((((....)))))))..(.....).))))))))).((.(((....(((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((.(...((..(((......)))))....).)))))..(..(((((.....))))).....)..)))).....).).)))...)..)))))....)))))))...)).)))))))).(...(((((((.....(((..((....((....))....))....)))......)))))))......(....(((((((........)))))))....)..)..))))).....(((((((..........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((..((((....(.((((..(((..((.....)).))).)))).)...))))..))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Cryo-EM structure of the Mycobacterium smegmatis 70S ribosome in complex with hibernation factor Rv2629 (Balon) (Structure 5); 16S Ribosomal RNA 8v9k y 74 3.1 RF00005 URS00005AA258_246196 38355796 0030533 0006412 246196 gcccgganagcucaggguagagcaggggauugaaaauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<......>>>><<<<<<<.....>>>>>>.>...<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[..)))).((((.........)))).....((.((..]....)).))))))))).... Cryo-EM structure of the Mycobacterium smegmatis 70S ribosome in complex with hibernation factor Rv2629 (Balon) (Structure 5); pe/E deacylated phenylanaline-tRNA 8v9k A 3081 3.1 RF02541 URS00003A7753_246196 38355796 0003735 0005840 246196 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((((......((((((((((.....(((..(((((((((((((......((((((.[[.[[[.))).....((((((...(((]]]..]].)))......))))))...)))....(((....)))(((((((......))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))....((([...((((((((((.........[[[[[.....))))))))))....(.((((.((.....(((.((.]]]]]..)).))).(((((.......((((.(.((((.(((...(.((((......)))))[[(...).(((.....]])))...)))...))))).)))))))))......).).))))]....(((((((...[.......)))))))....).(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((..(((((((((..)))).)))))..)))).<.(.(........).).((((((..(.(((.((((((((((..(((...(((....)))...)))...((....))..((((.....))))....(((((((....)))))))....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......A))))))))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))(((((((((.([.((((((((.....(((....(((.((((....(..((......))...)....)))).)))..)).).....))))))))....).]))))))).))..((((((((((......)))))).))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.((([.(((.........)))..))).....(]..((......)).).)))))...)))))))))).))...........]]].)....))))))))))...)))))))((((((((..))))))))....))))))(.((((((((((......((((((((....))).)))))...))))))))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]]((((((((((.(.....(((...(.((.((.......((((.((......)).))))......)).)).).....))).((...(((((...((((..(((..((((..(((((....{{....))))).((...((....(((((((((((.((.....))))))))).....))))..[.))....))...(((......))).....))))...)))...))))(..)....)))))..))..).)))))))))))))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((...((((....((((..)])))....))))..))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((....((((..((((((...))))))...))))....))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....))[[..(((((.....>]])))))..((((((((.(((.((......((((((((((..(((((.(((.(((((.((.((((.((((((((.(.........(((((...(........(((((((....))))))).....).............)))))).)))))))).)))).))...(((.((((((......)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.(.((((...((.......))...)))).)...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))..a.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..(((((...)))))....((((.((((.......)))).....(((.((((.(((....(((((....)))))...)))..))))..)))...))))....)))).. Cryo-EM structure of the Mycobacterium smegmatis 70S ribosome in complex with hibernation factor Rv2629 (Balon) (Structure 5); 23S Ribosomal RNA 8v9k B 118 3.1 RF00001 URS00000ACC0A_246196 38355796 0003735 0005840 246196 guuacggcgguccauagcggcagggaaacgcccggucccaucccgaacccggaagcuaagccugccagcgccgaugauacuacccauccggguggaaaaguaggacaccgccgaacac <<<.<<<<<<<.....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<.......<<<<<<....>>>>>>.......>>..>>>>>>>>>>.. (((.(((((((.....((((((((.....((((((...(.....)...))))..))....)))))).)).((.......((((((....)))))).......))..)))))))))).. Cryo-EM structure of the Mycobacterium smegmatis 70S ribosome in complex with hibernation factor Rv2629 (Balon) (Structure 5); 5S Ribosomal RNA 8v9l a 1511 3.0 RF00177,RF01959,RF02542,RF01960 URS00001AF2F7_246196 38355796 0003735 0005840 246196 uuuggagaguuugauccuggcucaggacgaacgcuggcggcgugcuuaacacaugcaagucgaacggaaaggcccuuucggggguacucgaguggcgaacgggugaguaacacgugggugaucugcccugcacuuugggauaagccugggaaacugggucuaauaccgaauacacccugcuggucgcauggccugguaggggaaagcuuuugcggugugggaugggcccgcggccuaucagcuuguugguggggugauggccuaccaaggcgacgacggguagccggccugagagggugaccggccacacugggacugagauacggcccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagcgacgccgcgugagggaugacggccuucggguuguaaaccucuuucagcacagacgaagcgcaagugacgguaugugcagaagaaggaccggccaacuacgugccagcagccgcgguaauacguaggguccgagcguuguccggaauuacugggcguaaagagcucguaggugguuugucgcguuguucgugaaaacucacagcuuaacugugggcgugcgggcgauacgggcagacuagaguacugcaggggagacuggaauuccugguguagcgguggaaugcgcagauaucaggaggaacaccgguggcgaaggcgggucucugggcaguaacugacgcugaggagcgaaagcguggggagcgaacaggauuagauacccugguaguccacgccguaaacgguggguacuagguguggguuuccuuccuugggauccgugccguagcuaacgcauuaaguaccccgccuggggaguacggccgcaaggcuaaaacucaaaggaauugacgggggcccgcacaagcggcggagcauguggauuaauucgaugcaacgcgaagaaccuuaccuggguuugacaugcacaggacgccggcagagaugucgguucccuuguggccugugugcagguggugcauggcugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuugucucauguugccagcacguuaugguggggacucgugagagacugccggggucaacucggaggaagguggggaugacgucaagucaucaugccccuuauguccagggcuucacacaugcuacaauggccgguacaaagggcugcgaugccgugagguggagcgaauccuuucaaagccggucucaguucggaucggggucugcaacucgaccccgugaagucggagucgcuaguaaucgcagaucagcaacgcugcggugaauacguucccgggccuuguacacaccgcccgucacgucaugaaagucgguaacacccgaagccgguggccuaacccuuguggagggagccgucgaaggugggaucggcgauugggacgaagucguaacaagguagccguaccggaaggugcggcuggauc ......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<.<<<<....>>>>..>>>..>>>>>......<<........<<<<<<<..<<...<<<<<<<<<<<<.....<<<<<......>>>>>......>>>>.....<<<<<<<<<<<<..>>>>>.>>>>>>>....<<....>>>>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<<....>>.......>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<.....<<<<<<<.....>>>>>>>...>>>>>>>..>>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<<..<<<......>>>.....>>>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<.......>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<.......<<<<<<...<<<<<<<....>>>>>>>.<<.....>>.>>>>>>..<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<<..<<<......>>>>>.....>>>>>>.....<<<<.......>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>......>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<..<<<<....<.<<<<..<<<..<<.....>>.>>>.>>>>.>...>>>>..>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... ......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(.(((......)))..)))..)))))......(((.......(((((((..((...(((((((((.((......(((((....))))).......)).).....((((((.((((....))))..))))))....((....))))))))))..))))))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(..((....))..)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((.....(((((((.....)))))))...))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((.(.......).))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..(((((((((.......((........))..........(((((.(..(...(.((((((..(((((((....)))))))..(.....).)))))).)).((.(((....(((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((.(...((..(((......)))))....).)))))..(..(((((.....))))).....)..)))).....).).)))...)..)))))....).)))))..[.).)))))))).(...(((((((.....(((..((...(((....)))...))....)))......)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((..((((....(.((((..(((..(((..).)).))).)))).)...))))..))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Cryo-EM structure of the Mycobacterium smegmatis 70S ribosome in complex with hibernation factor Msmeg1130 (Balon) and MsmegEF-Tu(GDP) (Composite structure 6); 16S Ribosomal RNA 8v9l y 74 3.0 RF00005 URS00005AA258_246196 38355796 0030533 0006412 246196 gcccgganagcucaggguagagcaggggauugaaaauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[..)))).((((.........)))).....((.((..]....)).))))))))).... Cryo-EM structure of the Mycobacterium smegmatis 70S ribosome in complex with hibernation factor Msmeg1130 (Balon) and MsmegEF-Tu(GDP) (Composite structure 6); pe/E deacylated phenylanaline-tRNA 8v9l A 3073 3.0 RF02541 URS00003A7753_246196 38355796 0003735 0005840 246196 aaguguuuaagggcgcaugguggaugccuuggcacugggagccgaugaaggacguaggaggcugcgauaagccucggggagcugucaaccgagcguugauccgaggauguccgaauggggaaacccggcacgagugaugucgugucaccaggcgcugaauauauaggcgucuggggggaacgcggggaagugaaacaucucaguacccguaggaagagaaaacaaaaugugauuccgugaguaguggcgagcgaaagcggaggauggcuaaaccguaugcaugugauaccggguagggguugugugugcgggguugugggaccuaucuuuccggcucuaccuggcuggagggcagugagaaaauguugugguuagcggaaauggcuugggauggccugccguagacggugagagcccgguacgugaaaacccgacgucugucuugaugguguucccgaguagcagcgggcccguggaaucugcugugaaucugccgggaccacccgguaagccugaauacuucccagugaccgauagcggauuaguaccgugagggaauggugaaaaguaccccgggaggggagugaaagaguaccugaaaccgugcgcuuacaauccgucagagcccucgacgugucguggggugauggcgugccuuuugaagaaugagccugcgagucagggacaugucgcgagguuaacccgggugggguagccgcagcgaaagcgagucugaauagggcguauccacacaagagugugugguguagugguguguucuggacccgaagcggagugaucuacccauggccagggugaagcgcggguaagaccgcguggaggcccgaacccacuuagguugaagacugaggggaugagcuguggguaggggugaaaggccaaucaaacuccgugauagcugguucuccccgaaaugcauuuaggugcagcgucgcauguuucuugccggagguagagcuacuggauggccgaugggccccacaggguuacugacgucagccaaacuccgaaugccgguaaguccaagagugcggcagugggacggcgggggauaagcuccgugcgucgagagggaaacagcccagaucgccggcuaaggccccuaagcgugugcuaaguggaaaaggaugugcagucgcgaagacaaccaggagguuggcuuagaagcagccacccuugaaagagugcguaauagcucacuggucaagugauugugcgccgauaauguagcggggcucaagcacaccgccgaagccgcggcagccaacguguuggcuggguaggggagcguccugcauccggugaagccgccgagugaucgagugguggagggugugggagugagaaugcaggcaugaguagcgauuaggcaagugagaaccuugcccgccgaaagaccaaggguuccugggccaggccaguccgcccagggugagucgggaccuaaggcgaggccgacaggcguagucgauggacaacggguugauauucccguacccguguaugugcguccaugaugaaucagcgguacuaaccauccgcaugggaccuucguugguaguagucaagcgauggggugacgcaggaagguagccguaccggucagugguaauaccgggguaagccuguagggagucagauagguaaauccgucuggcauauauccugagaggugaugcauagccgagugaggcgaauucggugauccuaugcugccgagaaaagccucuagcgaggacauacacggcccguaccccaaaccaacacagguggucagguagagaauacuaaggcguacgagugaacuaugguuaaggaacucggcaaaaugcccccguaacuucgggagaagggggacccacauggcguguaagccuuuacggcccaagcgugaguggguggcacaaaccagugagaagcgacuguuuacuaaaaacacagguccgugcgaagucgcaagacgauguauacggacugacgccugcccggugcuggaagguuaagaggacccguuaacucccuuugggggugaagcggagaauuuaagccccaguaaacggcggugguaacuauaaccauccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaacgacuucucaacugucucaaccauagacucggcgaaauugcacuacgaguaaagaugcucguuacgcgcggcaggacgaaaagaccccgggaccuucacuacaacuugguauuggugcucgauacgguuuguguaggauaggugggagacugugaagcucacacgccaguguggguggagucguuguugaaauaccacucugaucguauugggccucuaaccucggaccguauauccgguucagggacagugccugguggguaguuuaacuggggcgguugccuccuaaaauguaacggaggcgcccaaagguucccucaaccuggacggcaaucagguguugaguguaagugcacaagggagcuugacugcgagacggacaugucgagcagggacgaaagucgggacuagugauccggcaccucugaguggaaggggugucgcucaacggauaaaagguaccccggggauaacaggcugaucuuccccaagaguccauaucgacgggaugguuuggcaccucgaugucggcucgucgcauccuggggcuggagcaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguuuagaacgucgugagacaguucggucucuauccgccgcgcgcgucagaagcuugaggaaaccugucccuaguacgagaggaccgggacggacgaaccucugguauaccaguugucccaccaggggcacggcuggauagccacguucggacaggauaaccgcugaaagcaucuaagcgggaaaccucuuccaagaccaggcuucucacccucuaggagggauaaggccccccgcagaccacgggauugauagaccagaccuggaagccuaguaauaggugcagggaacuggcacuaaccggccgaaaacuuac 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((((......((((((((((.....(((..(((((((((((((......((((((.[[.[[[.))).....((((((...(((]]]..]].)))......))))))...)))....(((....)))(((((((......))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))....((([...(((((((((..........[[[[.[.....)))))))))....(.((((.((.....((((((.]]]]]..)))))).(((((.......((((((.((((.(((...(.((((......)))))[[(...).(((.....]])))...)))...)))))))))))))))......).).))))]....(((((((...[.......)))))))....).(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((..(((((((((..)))).)))))..)))).<.(.(........).).((((((..(.(((.((((((((((..(((...(((....)))...)))...((....))..((((.....))))....(((((((....)))))))....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......A))))))))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))(((((((((.([.((((((((.....(((....(((.((((....((.((......)).).)....)))).)))..)).).....))))))))....).]))))))).))..((((((((((......)))))).))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((.((((.....{.(((((.((([.(((.........)))..))).....(]..((......)).).)))))...)))).))))).))...........]]].)....))))))))))...)))))))((((((((..))))))))....))))))(.((((((((((......((((((((....))).)))))...))))))))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]]((((((((((.(.....(((...(.((.((....(..((((.().)))).)....)).)).).....))).((...(((((...((((..(((..((((..(((((....{{....))))).((..(((....(((((((((((.((.....))))))))).....))))..[.)))...))...(((......))).....))))...)))...))))(..)....)))))..))..).)))))))))))))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((...((((....((((..)])))....))))..))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((....((((..((((((...))))))...))))....))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....))[[..(((((.....>]])))))..((((((((.(((.((......((((((((((..(((((.(((.(((((.((.((.(((((((.((.(.........(((((............(.(((((....))))).)...................)))))).)).))))))).)).))...(((.((((((......)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.(.((((...((.......))...)))).)...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))..a.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..(((((...)))))....((((.((((.......)))).....(((.((((.(((....(((((....)))))...)))..))))..)))...))))....)))).. Cryo-EM structure of the Mycobacterium smegmatis 70S ribosome in complex with hibernation factor Msmeg1130 (Balon) and MsmegEF-Tu(GDP) (Composite structure 6); 23S Ribosomal RNA 8v9l B 118 3.0 RF00001 URS00000ACC0A_246196 38355796 0003735 0005840 246196 guuacggcgguccauagcggcagggaaacgcccggucccaucccgaacccggaagcuaagccugccagcgccgaugauacuacccauccggguggaaaaguaggacaccgccgaacac <<<.<<<<<<<.....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<.......<<<<<<....>>>>>>.......>>..>>>>>>>>>>.. (((.(((((((.....((((((((.....((((((...(.....)...))))..))....)))))).)).((.......((((((....)))))).......))..)))))))))).. Cryo-EM structure of the Mycobacterium smegmatis 70S ribosome in complex with hibernation factor Msmeg1130 (Balon) and MsmegEF-Tu(GDP) (Composite structure 6); 5S Ribosomal RNA 8vaj E 12 3.45 39368090 9606 uaaagugcuuag ............ ............ Human Argonaute3 bound to cityRNA and target RNA; RNA (5'-R(P*UP*AP*AP*AP*GP*UP*GP*CP*UP*UP*AP*G)-3') 8vaj F 12 3.45 39368090 9606 nagcacuuuaaa ............ ............ Human Argonaute3 bound to cityRNA and target RNA; RNA (5'-R(P*(SRA)P*AP*GP*CP*AP*CP*UP*UP*UP*AP*AP*A)-3') 8vaw A 15 1.25 38579124 32630 nnnnacuuaagucgn ............... ............... Magnesium catalyzed primer extension product with 14mer primer and mixed phosphorothioate activated G monomer; Magnesium catalyzed nonenzymatic RNA primer extension product 8vaw B 15 1.25 38579124 32630 nnnnacuuaagucgn ............... ............... Magnesium catalyzed primer extension product with 14mer primer and mixed phosphorothioate activated G monomer; Magnesium catalyzed nonenzymatic RNA primer extension product 8vax AAA 15 1.417 38579124 32630 nnnnacuuaagucgn ............... ............... Cadmium catalyzed primer extension product with 14mer primer and mixed phosphorothioate activated G monomer; Cadmium catalyzed nonenzymatic RNA primer extension product 8vax BBB 15 1.417 38579124 32630 nnnnacuuaagucgn ............... ............... Cadmium catalyzed primer extension product with 14mer primer and mixed phosphorothioate activated G monomer; Cadmium catalyzed nonenzymatic RNA primer extension product 8vfs A 27 2.7 38992441 588 agcuugcuuuaagccgcuggaggagcu ........................... ........................... oppF ROSE-like RNA thermometer structure; RNA (27-MER) 8vfs B 27 2.7 38992441 588 agcuugcuuuaagccgcuggaggagcu ........................... ........................... oppF ROSE-like RNA thermometer structure; RNA (27-MER) 8vft 5 3529 3.3 RF02540,RF02543,RF02541 0003735 0005840 9986 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggaaauguggcguacggaagacccaccccggcgccggggggcccaaguccuucugaucgaggcccagcccguggacggugugagnccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaanggaaaguugaaaagaacuuugaagngngaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcgcgguccggccgugccggcggggcggaucucccgcucccgucggcgggggaccgccccccggccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggccccggcggggaagguggcccgggggccccggguguuacagccccgccccggcagcagcagcucgccgaaucccggggccgagggagcgagacccgugcgccgcgcucuccccccucgggggggccgggccaccccucccacggcgcgaccgcuggggcggacuguccagugcgccccgggcgggucgcgccgucgggcccggggggccacgcgagcgcacggggucggcggcgaugucggcuacccacccgacccnucuugnaacncggaccaaggagunuaacacgugcgcgagucgggggcuacgaaagccgccguggcgcaaugaaggugaaggccggcggcgcgccgccggccgaggugggaucccgaggccuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuagnacccnanagauggugancuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcgaaucggucguccgaccuggguauagnggcgaaagacuaaucgaaccaucuaguagcugguucccuccaaaguuucccucaggauagcuggcgcucuccgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcugguguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcngaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccaugaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgcuggcagucggcagagcgagaaagagaguggcgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaunuuggugguagunnnaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagnanuugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucagccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccnuauccgcagcaggucuncaaggugaacngccucuggnauguuggaacaanguagguaagggaagucggcaagcnggauccguaacuucnggauaaggauuggcucuaagggcuggcagccgacuuagaacuggugcggaccaggngaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugccnagugcucugaaugucanagugangaaauucaaugaagcgcggguaaacggcgggaguancuaugacucucuuaagguagcnaanugccucnucaucuaauuagugangcgcaugaanggaugancgagnuucccacugunccuaccuacuauccagcgaaaccacngncaagggaacgggcuuggnggaaucagcggngaaagaagacccuguugagcuugacncuagucuggcacggugaagagacguuuuuucacugacccggugaggcgggggggcgagccgggcucucgcuucuggcgccaagcgcccggccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacugnggcgguacaccugucaaacgguancgcaggnnuccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucagnacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggangugucagaaaaguuaccacagngauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuungaugucggnucuuccuaucauugugaagcagaauucaccaagcguungaunnuucacccacuaauagggaacgugngcugggnuuagancgucgugagacagguuaguuuuacccuacugaugnuguguuguugccaugguaauccugcucaguacgagaggaaccgcagnuncanacauuugguguaunugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauagcgccggagccucgguuggccucggauagccggucccccgccgggguccggugcggagagcccuucgucccgggaaacgggcggccggaaagggggccgcccucucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcugcugcgaucuauugaaagucagcccucgacacaaggguuugu 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.........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..(((((((((((.....)))))).))))....))))....(((((((((..(.((((((.(((((((((..({((((......)))))....[[(...).(((....}]])))...).)))))))..))))))).)...)))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....((((((((((.(..(((((((.(((((.(((((((.(((((((((..()..)))))))))))))))))))))))))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((..(((((((......((((((((.)))))))).......)))))))..))).........))))))..))))))))))).....((.....{.))..........((.((((((()))))))...(.((..(((.((((((((((((((((.((((((.((((..)))).))))))..)).))))))))))).)))...))))).)...[.).)........))).)))))...)))))...)))))))).<((((........))))((((((....(((((((((((((..(((..((((.......)))..)..)))...((....))...((((((((((()))))))))))..(((((...(((..(((].[[[.[[[)))..)))....))))).((((.((((.((((......)))))))).)).))....)))))))))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)<)))...(((..((.((.......B)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((...(((.((((((((.....((.....((....(((..(((.(...........).))))))....))...))......))))))...(((((((((.(......))))))))))....))))))))))))..))..((((..(.((.....)).)..))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.....A.(((((.(((...((........))...))).........((......))...)))))...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((........}.........].]].]]]............)))))))))....)))))).(.((((((((.((......(((..((((....)))).)))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...(...(.(((....))).....)....((.((((.((((...))).))))))).......)....))...(((((........)))))]]((((....(((((...(((((((....)))))))..((((....)))...(...((((((...((((((((((((((((((((((....{{...)))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).)))..)).....((......)).)))).((((.....))))..)))....(((......(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((.)))))..)))))).))(...).......(((((((((.>.(...........)...(((((((....((((.....))))......))))))).].(.(.(((..((((((.(...(......((((....))))......).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....).)....)).))))))).)..))).)))))))...)))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.(((((...(((((.(((((((((.(((((((((..)))))))))...(((((.....((((..((.(.((..).)).))..............(((((.(((..))).)))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(..((..(.((....{..)).)..)).)(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}.....)))..)))))).......(....(.((((((...((.......))...))))))...)....)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).)......((((((....))).)))...b.))..))).))))).....((((.(.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}..)))))..)).))...))))...)))).((((...((((.....a.......))))...))))..)))...).).)))).(((((.(..((((....(((.........((((...((((.))))..))))........)))...(((..(((.....(.(((.((........)).))..).)....)))..)))..............))))..)..))))).(((((.(..(.......)..)....((.(((((((.((.....((((.(..(((((.)))))..)))))....))....)))).))).))..))))).. Translating 80S rabbit ribosome stalled by emetine with eEF2; 28S rRNA 8vft 7 120 3.3 RF00001 0003735 0005840 9986 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. Translating 80S rabbit ribosome stalled by emetine with eEF2; 5S rRNA 8vft 8 156 3.3 RF00002,RF02540 0003735 0005840 9986 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauuncaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<<<<....>>>>.....<.<<<......>>.............>>>..>...>>>....<<<..>>><<<<<<<<.......>>>>>>>>.................... .........................................((((((.[[....[)))...].(.(((......]].............)))..)...)))....((....))((((((((.......)))))))).................... Translating 80S rabbit ribosome stalled by emetine with eEF2; 5.8S rRNA 8vft 9 1698 3.3 RF01960,RF02542,RF01959,RF00177 0003735 0005840 9986 uaccugguugauccugccaguagcaunugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuauggunccuunggucgcucguacuuggauaacugugguanuucuagngcuaauanaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgcccggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcnaauuacccacucccgacccgggganguagugangaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugagucnacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauancguauauuaaaguugcugcaguunaaaagcucguaguungaucuugggagcggccguccccugcucggcgccggcccgaagcguuuacuuugaaaaaanuagaguguucaaagcaggccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagancgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccacnaggaguggagccugcggcuuaauuugacncaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggcnguucuuaguugguggagcgauuugucugguuaauucngauaacgaacgagacucuggcaugcuaacuaguuacgcgaccccggucggcguaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauunagucccugcccuuuguacacaccgnccgucgnuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggugcccuggcggagcgcugagaagacggucgaacuugncuaucuagaggaaguaaaagucgnancaagguuucnguaggugnnccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<..<.....<<<.<....<<....<<<<<.........<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<<<....>>>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<..<<<.>>>.>>>>.>>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<.[..>>>>....>>>>>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....<<<<<<<<<.<<<....>>>..>>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.......].<.<((.....<.<<...<<<.<<....<<<.<<<..>>>.>>><<<<<<<.<<..>>>>>>.>>>.<<<<<<.<.......<<...<.......>.<<<<.>>>>...>>......>.>>>..>>>........<.<<.<<<<<<<...............>>>>>>>.>>.>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<........<<........>>..........<<<<<.<....<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<..<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<..>>>>.>>>>>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>......>>>>>>.....>.>>>>>......>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>............<<<<<..........>>>>>...........>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<<<<<<<<<<<..>>>>>>>>>.>.>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..(......(((.(((..(.....((....((..........))...))[.)......(((.......(((.(.(..((....(((.....(([...((.....((.(((.....))).))......))......)).((((...(((((......)))))...))))((..(((((...(......)..)))))......)).(]((((..(((.))).)))))...)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).......(.(((...((((.]...))).))))).)...)).).....(((((((((....(...)....)))))).)))....(.((..(...........)..))......)...(((([[......((((.....((..]])).......)))).))))...)))))).)))..[......(.([[...(.(.((...(((..(.....((..((()))..))..(.((((.((()))))))..)..((((((.(.......((..(.........).(((.)))....))......).)))..)))........(.((.((((((.................)))))).)).)....)....(((..((..(...((((..((..((((((((...((........))......))))))))..)).......((....))...))))..)..))...))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.((.((....)).)))))))).)..)))...((..]]))...))...].))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((..((........))..))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((...(...((((..((((((((((((..)))).))))))))..))))..).....(((((.....)))))........)))....))).))).....).))))).....).)))))...)).)))).))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..(((..((..(.((((((((.(((..((((.((...(((((((((((((((..))))))))).).)))))...)).))))..))).)))))))))..))..)))...).))...)..)..(((((((((....)))))))))}........ Translating 80S rabbit ribosome stalled by emetine with eEF2; 18S rRNA 8vft 3 74 3.3 RF00005 0030533 9986 gcccggauagcucagcugagagcaucagacuuuuaaucugaggguccaggguucaagucccuguucgggcgcca <<<<<<<..<<<<......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((.(..((((....[.)))).(((((.......))))).....(((((..]....)))))).))))).... Translating 80S rabbit ribosome stalled by emetine with eEF2; E-site tRNA 8vft 2 74 3.3 9986 gucuccguaguguagcggaucacguucgccuaauacgcgaaggguccucgguucgaaaccgggcggaaacacca <<.<<<<..<<<........>>>.<<<<<.......>>>>>.....<<<<<<.....>>>>>>>>>>.>>.... ((.((((..(((.....[..))).(((((.......))))).....(((((..]....))))))))).)).... Translating 80S rabbit ribosome stalled by emetine with eEF2; P-site tRNA 8vio A 3119 3.26 RF02540,RF02541,RF02543,RF00002 39913204 0003735 0005840 246196 aaguguuuaagggcgcaugguggaugccuuggcacugggagccgaugaaggacguaggaggcugcgauaagccucggggagcugucaaccgagcguugauccgaggauguccgaauggggaaacccggcacgagugaugucgugucaccaggcgcugaauauauaggcgucuggggggaacgcggggaagugaaacaucucaguacccguaggaagagaaaacaaaaugugauuccgugaguaguggcgagcgaaagcggaggauggcuaaaccguaugcaugugauaccggguagggguugugugugcgggguugugggaccuaucuuuccggcucuaccuggcuggagggcagugagaaaauguugugguuagcggaaauggcuugggauggccugccguagacggugagagcccgguacgugaaaacccgacgucugucuugaugguguucccgaguagcagcgggcccguggaaucugcugugaaucugccgggaccacccgguaagccugaauacuucccagugaccgauagcggauuaguaccgugagggaauggugaaaaguaccccgggaggggagugaaagaguaccugaaaccgugcgcuuacaauccgucagagcccucgacgugucguggggugauggcgugccuuuugaagaaugagccugcgagucagggacaugucgcgagguuaacccgggugggguagccgcagcgaaagcgagucugaauagggcguauccacacaagagugugugguguagugguguguucuggacccgaagcggagugaucuacccauggccagggugaagcgcggguaagaccgcguggaggcccgaacccacuuagguugaagacugaggggaugagcuguggguaggggugaaaggccaaucaaacuccgugauagcugguucuccccgaaaugcauuuaggugcagcgucgcauguuucuugccggagguagagcuacuggauggccgaugggccccacaggguuacugacgucagccaaacuccgaaugccgguaaguccaagagugcggcagugagacggcgggggauaagcuccgugcgucgagagggaaacagcccagaucgccggcuaaggccccuaagcgugugcuaaguggaaaaggaugugcagucgcgaagacaaccaggagguuggcuuagaagcagccacccuugaaagagugcguaauagcucacuggucaagugauugugcgccgauaauguagcggggcucaagcacaccgccgaagccgcggcagccaacguguuggcuggguaggggagcguccugcauccggugaagccgccgagugaucgagugguggagggugugggagugagaaugcaggcaugaguagcgauuaggcaagugagaaccuugcccgccgaaagaccaaggguuccugggccaggccaguccgcccagggugagucgggaccuaaggcgaggccgacaggcguagucgauggacaacggguugauauucccguacccguguaugugcguccaugaugaaucagcgguacuaaccauccaaaaccaccgugaccgcaccuuucgggguguggcguugguggggcugcaugggaccuucguugguaguagucaagcgauggggugacgcaggaagguagccguaccggucagugguaauaccgggguaagccuguagggagucagauagguaaauccgucuggcauauauccugagaggugaugcauagccgagugaggcgaauucggugauccuaugcugccgagaaaagccucuagcgaggacauacacggcccguaccccaaaccaacacagguggucagguagagaauacuaaggcguacgagugaacuaugguuaaggaacucggcaaaaugcccccguaacuucgggagaagggggacccacauggcguguaagccuuuacggcccaagcgugaguggguggcacaaaccagugagaagcgacuguuuacuaaaaacacagguccgugcgaagucgcaagacgauguauacggacugacgccugcccggugcuggaagguuaagaggacccguuaacucccuuugggggugaagcggagaauuuaagccccaguaaacggcggugguaacuauaaccauccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaacgacuucucaacugucucaaccauagacucggcgaaauugcacuacgaguaaagaugcucguuacgcgcggcaggacgaaaagaccccgggaccuucacuacaacuugguauuggugcucgauacgguuuguguaggauaggugggagacugugaagcucacacgccaguguggguggagucguuguugaaauaccacucugaucguauugggccucuaaccucggaccguauauccgguucagggacagugccugguggguaguuuaacuggggcgguugccuccuaaaauguaacggaggcgcccaaagguucccucaaccuggacggcaaucagguguugaguguaagugcacaagggagcuugacugcgagacggacaugucgagcagggacgaaagucgggacuagugauccggcaccucugaguggaaggggugucgcucaacggauaaaagguaccccggggauaacaggcugaucuuccccaagaguccauaucgacgggaugguuuggcaccucgaugucggcucgucgcauccuggggcuggagcaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguuuagaacgucgugagacaguucggucucuauccgccgcgcgcgucagaagcuugaggaaaccugucccuaguacgagaggaccgggacggacgaaccucugguauaccaguugucccaccaggggcacggcuggauagccacguucggacaggauaaccgcugaaagcaucuaagcgggaaaccucuuccaagaccaggcuucucacccucuaggagggauaaggccccccgcagaccacgggauugauagaccagaccuggaagccuaguaauaggugcagggaacuggcacuaaccggccgaaaacuuac <<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<<......<<<<<<.[[.(((.>>>.....<<<<<<<..<<<)))..]].>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<.....>>..<<<<<<.....<<.....>>....>>>>>>...<<<....<<<<<<<<<<.........<<<<......>>>>>>>>>>......<<<<..[.....<<<<<<..>>>>..>>>>>><<<<<<.......<<<<<<.<<<<.<<<.....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>>>.....]...>>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..>>>......>>.>>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<<<<..>>>>.>>>>>..>>>>...<.<........>.>.<<<<<<....<<<.<<<<<<<<<<..<<<...<<<<..>>>>...>>>...<<....>>..<<<<.....>>>>....<<<<<<<....>>>>>>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<....<<<<<<<<.....<<<....<<<.<<<<.<....<<<......>>>......>>>>>.>>>..>>.>.....>>>>>>>>.......>>>>>>>.>>..<<<<<<<<<<......>>>>>>.>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>...........)))......>>>>>>.>>>...>>>>>>><<<<<<<<..>>>>>>>>....>>>>>><.<<<<<<<<<<......<<<<<<<<....>>>.>>>>>...>>>>>>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<.<.<<<...<<<....>>>...>>>..>>>...<<<<<........>>>>>))<<<<<<<<<<.......<<....<<<<<..<......<<<<.......<<<<<...<<<<<<<<....>>>>>>>>...>>>>>.......>>>>.....>..>>>>>......>>.<<...<<<<<...<<<<..<<<..<<<<..<<<<<...((((...>>>>>.<<..<<<<...<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>...>>>>...>>...<<<......>>>.....>>>>...>>>...>>>>........>>>>>..>>....>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<<...<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<...<<<<....<<<.....>>>....>>>>..>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.<<<....<<<<<.<<<<<<...>>>>>>..>>>>>....>>>.>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>>>>>>>>.....>.((..<<<<<......))>>>>>..<<<<<<<<.<<<.<<......<<<<<<<<<<..<<<<<.<<<.<<<<<.<<.<<<<<<<<<<<.<...........<<<<<...........<<<<<<<<....>>>>>>>>..................>>>>>..>.>>>>>>>>>>>.>>...<<<.<<<<<<......>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.<<..>>>>..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<.<<<<...<<.......>>...>>>>.>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))))>>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<<...>>>>>....<<<<.<<<<.......>>>>.....<<<.<<<<.<<<....<<<<<....>>>>>...>>>..>>>>..>>>...>>>>....>>>>.. ((((......((((((((((.....(((..(((((((((((((......((((((.[[.[[[.))).....((((((...(((]]]..]].)))......))))))...)))....(((....)))(((((((......))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))....((([...(((((.(((..........[[[[.[.....))).)))))....(.((((........(((((..]]]]]...))))).(((((.......((((((.((((.(((...(.((((......)))))[[(...).(((.....]])))...)))...)))))))))))))))..........))))]....(((((((...[.......)))))))....).(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((..(((((((((..)))).)))))..)))).<.(.(........).).((((((..(.(((.((((((((((..((....(((....)))....))...((....))..((((.....))))....(((((((....)))))))....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......A))))))))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))(((((((((.([.((((((((.....(((....(((.((((.......(((....)))........)))).)))..)).).....))))))))....).]))))))).))..((((((((((......)))))).))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((..(...(((.........)))...)......(...((......)).).)))))...)))))))))).))...........]]].)....))))))))))...)))))))((((((((..))))))))....))))))(.((((((((((......((((((((....))).)))))...))))))))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]]((((((((((.(.....(.....(.((.(.(......((((..........((....((((((......))))))...).)..........)))).....).).)).).......).((...(((((...((((..(((..((((..(((((....{{....))))).((..(((....(((((((((((.((.....))))))))).....))))..[.)))...))...(((......))).....))))...)))...))))(..)....)))))..))..).)))))))))))))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((...((((....((((..)])))....))))..))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((....((((..((.(.(....)).))...))))....))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....))[[..(((((.....>]])))))..((((((((.(((.((......((((((((((..(((((.(((.(((((.((.((.((((.(((((.(.........((((.............(.(((((....)))).))....................))))).))))).)))).)).))...(((.((((((......)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.(.((((...((.......))...)))).)...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..a.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..(((((...)))))....((((.((((.......)))).....(((.((((.(((....(((((....)))))...)))..))))..)))...))))....)))).. Structure of Mycobacterium smegmatis HflX bound to a 70S ribosome; 23S ribosomal RNA 8vio B 118 3.26 RF00001 39913204 0003735 0005840 246196 guuacggcgguccauagcggcagggaaacgcccggucccaucccgaacccggaagcuaagccugccagcgccgaugauacuacccauccggguggaaaaguaggacaccgccgaacac <<<.<<<<<<<.....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<.......<<<<<<....>>>>>>.......>>..>>>>>>>>>>.. (((.(((((((.....((((((((.....(.((((...(.....)...))))...)....)))))).)).((.......((((((....)))))).......))..)))))))))).. Structure of Mycobacterium smegmatis HflX bound to a 70S ribosome; 5S ribosomal RNA 8vio 5 77 3.26 RF00005 39913204 0030533 246196 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(.(((..]....))).)))))))..... Structure of Mycobacterium smegmatis HflX bound to a 70S ribosome; E-tRNA 8vio a 1511 3.26 RF00177,RF01959,RF02542,RF01960 39913204 0003735 0005840 246196 uuuggagaguuugauccuggcucaggacgaacgcuggcggcgugcuuaacacaugcaagucgaacggaaaggcccuuucggggguacucgaguggcgaacgggugaguaacacgugggugaucugcccugcacuuugggauaagccugggaaacugggucuaauaccgaauacacccugcuggucgcauggccugguaggggaaagcuuuugcggugugggaugggcccgcggccuaucagcuuguugguggggugauggccuaccaaggcgacgacggguagccggccugagagggugaccggccacacugggacugagauacggcccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagcgacgccgcgugagggaugacggccuucggguuguaaaccucuuucagcacagacgaagcgcaagugacgguaugugcagaagaaggaccggccaacuacgugccagcagccgcgguaauacguaggguccgagcguuguccggaauuacugggcguaaagagcucguaggugguuugucgcguuguucgugaaaacucacagcuuaacugugggcgugcgggcgauacgggcagacuagaguacugcaggggagacuggaauuccugguguagcgguggaaugcgcagauaucaggaggaacaccgguggcgaaggcgggucucugggcaguaacugacgcugaggagcgaaagcguggggagcgaacaggauuagauacccugguaguccacgccguaaacgguggguacuagguguggguuuccuuccuugggauccgugccguagcuaacgcauuaaguaccccgccuggggaguacggccgcaaggcuaaaacucaaaggaauugacgggggcccgcacaagcggcggagcauguggauuaauucgaugcaacgcgaagaaccuuaccuggguuugacaugcacaggacgccggcagagaugucgguucccuuguggccugugugcagguggugcauggcugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuugucucauguugccagcacguuaugguggggacucgugagagacugccggggucaacucggaggaagguggggaugacgucaagucaucaugccccuuauguccagggcuucacacaugcuacaauggccgguacaaagggcugcgaugccgugagguggagcgaauccuuucaaagccggucucaguucggaucggggucugcaacucgaccccgugaagucggagucgcuaguaaucgcagaucagcaacgcugcggugaauacguucccgggccuuguacacaccgcccgucacgucaugaaagucgguaacacccgaagccgguggccuaacccuuguggagggagccgucgaaggugggaucggcgauugggacgaagucguaacaagguagccguaccggaaggugcggcuggauc ......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<....>>>>>.>.>..>>>>>......<<........<<<<<<<..<<...<<<<<<<<<<<<....<<<<<<<....>>>>>>.>....>>>>.....<<<<<<<<<<<<..>>>>>.>>>>>>>....<<....>>>>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<.......<<<....>>>......>>>>.....<<<<<......<......>.......>>>>>.......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<.....<<<<<<<.....>>>>>>>...>>>>>>>..>>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<<..<<<......>>>.....>>>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<.......>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<.......<<........<<<<<<<....>>>>>>>..<.....>.......>>.<<<.<<<..<<<<<<<......<<<<<.............<<<<......>>>>...>>>>>.....<....<<<<<<....<<..<<<......>>>>>.....>>>>>>.....<<..<......>.>>...........>.......>.>>>...>>>>>>>>>....>>>>>>...>>.>>>>>>>>.....<<<<<<<..........<<...<<<....>>>...>>.............>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<..<<<<....<.<<<<..<<<..<<.....>>.>>>.>>>>.>...>>>>..>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... ......((((....[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(.((((....))))..)))..)))))......(((.......(((((((..((...(((((((.((((.....(.((((....))))..).....)))).....((((.((((((....)))).)).))))....((....)).)))))))..))))))))).(((....(((...(((((((.......))))))).)))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((........((....)).......))))...(.(((((...(..((....))..)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.(((.((.(((.....(.(((((.....))))).)...))).)).)..)))))))))..(((((((((...((((((((....(((((.(...((........))......).)))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((.(.......).))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]]..(((((.(((((((.((..(((((..(((((((((.......((........))..........((((((...(...(.....(....(((.((....)).)))...(.....).)......)).((.(((...(((.((.(....(((((..............(((......)))....))))).....(..(.(((((.(...((..(((......)))))....).)))))..(.....(........).......)..)..).....).).).)...)).))))).....))))))....).)))))))).(....((((((.......(..((....((....))....)).....).......))))))............(((((((........))))))).......)..))))).....(.(((((..........))))).)......))...)))))))))).))..(.(..((.(.((((.(((..((((((..((((....(.((((..((...(((..).))..)).)))).)...))))..))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Structure of Mycobacterium smegmatis HflX bound to a 70S ribosome; 16S ribosomal RNA 8vk0 A 3119 3.14 RF02540,RF02541,RF02543,RF00002 39913204 0003735 0005840 246196 aaguguuuaagggcgcaugguggaugccuuggcacugggagccgaugaaggacguaggaggcugcgauaagccucggggagcugucaaccgagcguugauccgaggauguccgaauggggaaacccggcacgagugaugucgugucaccaggcgcugaauauauaggcgucuggggggaacgcggggaagugaaacaucucaguacccguaggaagagaaaacaaaaugugauuccgugaguaguggcgagcgaaagcggaggauggcuaaaccguaugcaugugauaccggguagggguugugugugcgggguugugggaccuaucuuuccggcucuaccuggcuggagggcagugagaaaauguugugguuagcggaaauggcuugggauggccugccguagacggugagagcccgguacgugaaaacccgacgucugucuugaugguguucccgaguagcagcgggcccguggaaucugcugugaaucugccgggaccacccgguaagccugaauacuucccagugaccgauagcggauuaguaccgugagggaauggugaaaaguaccccgggaggggagugaaagaguaccugaaaccgugcgcuuacaauccgucagagcccucgacgugucguggggugauggcgugccuuuugaagaaugagccugcgagucagggacaugucgcgagguuaacccgggugggguagccgcagcgaaagcgagucugaauagggcguauccacacaagagugugugguguagugguguguucuggacccgaagcggagugaucuacccauggccagggugaagcgcggguaagaccgcguggaggcccgaacccacuuagguugaagacugaggggaugagcuguggguaggggugaaaggccaaucaaacuccgugauagcugguucuccccgaaaugcauuuaggugcagcgucgcauguuucuugccggagguagagcuacuggauggccgaugggccccacaggguuacugacgucagccaaacuccgaaugccgguaaguccaagagugcggcagugagacggcgggggauaagcuccgugcgucgagagggaaacagcccagaucgccggcuaaggccccuaagcgugugcuaaguggaaaaggaugugcagucgcgaagacaaccaggagguuggcuuagaagcagccacccuugaaagagugcguaauagcucacuggucaagugauugugcgccgauaauguagcggggcucaagcacaccgccgaagccgcggcagccaacguguuggcuggguaggggagcguccugcauccggugaagccgccgagugaucgagugguggagggugugggagugagaaugcaggcaugaguagcgauuaggcaagugagaaccuugcccgccgaaagaccaaggguuccugggccaggccaguccgcccagggugagucgggaccuaaggcgaggccgacaggcguagucgauggacaacggguugauauucccguacccguguaugugcguccaugaugaaucagcgguacuaaccauccaaaaccaccgugaccgcaccuuucgggguguggcguugguggggcugcaugggaccuucguugguaguagucaagcgauggggugacgcaggaagguagccguaccggucagugguaauaccgggguaagccuguagggagucagauagguaaauccgucuggcauauauccugagaggugaugcauagccgagugaggcgaauucggugauccuaugcugccgagaaaagccucuagcgaggacauacacggcccguaccccaaaccaacacagguggucagguagagaauacuaaggcguacgagugaacuaugguuaaggaacucggcaaaaugcccccguaacuucgggagaagggggacccacauggcguguaagccuuuacggcccaagcgugaguggguggcacaaaccagugagaagcgacuguuuacuaaaaacacagguccgugcgaagucgcaagacgauguauacggacugacgccugcccggugcuggaagguuaagaggacccguuaacucccuuugggggugaagcggagaauuuaagccccaguaaacggcggugguaacuauaaccauccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaacgacuucucaacugucucaaccauagacucggcgaaauugcacuacgaguaaagaugcucguuacgcgcggcaggacgaaaagaccccgggaccuucacuacaacuugguauuggugcucgauacgguuuguguaggauaggugggagacugugaagcucacacgccaguguggguggagucguuguugaaauaccacucugaucguauugggccucuaaccucggaccguauauccgguucagggacagugccugguggguaguuuaacuggggcgguugccuccuaaaauguaacggaggcgcccaaagguucccucaaccuggacggcaaucagguguugaguguaagugcacaagggagcuugacugcgagacggacaugucgagcagggacgaaagucgggacuagugauccggcaccucugaguggaaggggugucgcucaacggauaaaagguaccccggggauaacaggcugaucuuccccaagaguccauaucgacgggaugguuuggcaccucgaugucggcucgucgcauccuggggcuggagcaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguuuagaacgucgugagacaguucggucucuauccgccgcgcgcgucagaagcuugaggaaaccugucccuaguacgagaggaccgggacggacgaaccucugguauaccaguugucccaccaggggcacggcuggauagccacguucggacaggauaaccgcugaaagcaucuaagcgggaaaccucuuccaagaccaggcuucucacccucuaggagggauaaggccccccgcagaccacgggauugauagaccagaccuggaagccuaguaauaggugcagggaacuggcacuaaccggccgaaaacuuac 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((((......((((((((((.....(((..(((((((((((((......((((((.[[.[[[.))).....((((((...(((]]]..]].)))......))))))...)))....(((....)))(((((((......))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))....((([...((((((.(((..........[.[[.....))).))))))....(.(((((.(.....((((((.]].]...)))))).(((((.......((((((.((((.(((...(.((((......)))))[[(...).(((.....]])))...)))...)))))))))))))))......).).))))]....(((((((...[.......)))))))....).(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(...(((....))).............)).....)))))))))).....(.((((..(((((((((..)))).)))))..)))).<.(.(........).).((((((..(.(((.((((((((((..(((...(((....)))...)))...((....))..((((.....))))....(((((((....)))))))....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......A))))))))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))(((((((((.([.((((((((.....(((....(((.((((....(.((........))..)....)))).)))..)).).....))))))))....).]))))))).))..((((((((((......)))))).))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((..(....(.....{.((...........(.........)............(....(......)..)....))...)...)...)).))...........]]].)....))))))))))...)))))))((((((((..))))))))....))))))(.((((((((((......((((((((....))).)))))...))))))))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]]((((((((((.(.....(((...(((...........((((.((...(((((....((((((........))))))....)))).)..)).))))..........))).....))).((...(((((...((((..(((..((((..(((((....{{....))))).((..(((....(((((((((((.((.....))))))))).....))))..[.)))...))...(((......))).....))))...)))...))))(..)....)))))..))..).)))))))))))))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((...((((....(((....])))....))))..))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((....((((..((.(((...))).))...))))....))...))))))))..)))))(.................)........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....))[[..(((((.....>]])))))..((((((((.(((.((......((((((((((..(((((.(((.(((((.((.((((.((((..(..(................(.........(.(((((....))))).)......).................)..)..)))).)))).))...(((.((((((......)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.(.((((...((.......))...)))).)...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..a.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..(((((...)))))....((((.((((.......)))).....(((.((((.(((....(((((....)))))...)))..))))..)))...))))....)))).. Structure of Mycobacterium smegmatis 50S ribosomal subunit bound to HflX:50S-HflX-A; 23S ribosomal RNA 8vk0 B 118 3.14 RF00001 39913204 0003735 0005840 246196 guuacggcgguccauagcggcagggaaacgcccggucccaucccgaacccggaagcuaagccugccagcgccgaugauacuacccauccggguggaaaaguaggacaccgccgaacac <<..<<<<<<<.....<<<<<<<<.....<<<<<<.............>>>>..>>....>>>>>>.>>.<<.......<<<<<<....>>>>>>.......>>..>>>>>>>.>>.. ((..((.(.((.....((((((((.....((((((...(.....)...))))..))....)))))).)).((.......((((((....)))))).......))..).))).).)).. Structure of Mycobacterium smegmatis 50S ribosomal subunit bound to HflX:50S-HflX-A; 5S ribosomal RNA 8vk7 A 2950 3.09 RF02540,RF02541,RF02543,RF00002 39913204 0003735 0005840 246196 aaguguuuaagggcgcaugguggaugccuuggcacugggagccgaugaaggacguaggaggcugcgauaagccucggggagcugucaaccgagcguugauccgaggauguccgaauggggaaacccggcacgagugaugucgugucaccaggcgcugaauauauaggcgucuggggggaacgcggggaagugaaacaucucaguacccguaggaagagaaaacaaaaugugauuccgugaguaguggcgagcgaaagcggaggauggcuaaaccguaugcaugugauaccggguagggguugugugugcgggguugugggaccuaucuuuccggcucuaccuggcuggagggcagugagaaaauguugugguuagcggaaauggcuugggauggccugccguagacggugagagcccgguacgugaaaacccgacgucugucuugaugguguucccgaguagcagcgggcccguggaaucugcugugaaucugccgggaccacccgguaagccugaauacuucccagugaccgauagcggauuaguaccgugagggaauggugaaaaguaccccgggaggggagugaaagaguaccugaaaccgugcgcuuacaauccgucagagcccucgacgugucguggggugauggcgugccuuuugaagaaugagccugcgagucagggacaugucgcgagguuaacccgggugggguagccgcagcgaaagcgagucugaauagggcguauccacacaagagugugugguguagugguguguucuggacccgaagcggagugaucuacccauggccagggugaagcgcggguaagaccgcguggaggcccgaacccacuuagguugaagacugaggggaugagcuguggguaggggugaaaggccaaucaaacuccgugauagcugguucuccccgaaaugcauuuaggugcagcgucgcauguuucuugccggagguagagcuacuggauggccgaugggccccacaggguuacugacgucagccaaacuccgaaugccgguaaguccaagagugcggcagugagacggcgggggauaagcuccgugcgucgagagggaaacagcccagaucgccggcuaaggccccuaagcgugugcuaaguggaaaaggaugugcagucgcgaagacaaccaggagguuggcuuagaagcagccacccuugaaagagugcguaauagcucacuggucaagugauugugcgccgauaauguagcggggcucaagcacaccgccgaagccgcggcagccaacguguuggcuggguaggggagcguccugcauccggugaagccgccgagugaucgagugguggagggugugggagugagaaugcaggcaugaguagcgauuaggcaagugagaaccuugcccgccgaaagaccaaggguuccugggccaggccaguccgcccagggugagucgggaccuaaggcgaggccgacaggcguagucgauggacaacggguugauauucccguacccguguaugugcguccaugaugaaucucguugguaguagucaagcgauggggugacgcaggaagguagccguaccggucagugguaauaccgggguaagccuguagggagucagauagguaaauccgucuggcauauauccugagaggugaugcauagccgagugaggcgaauucggugauccuaugcugccgagaaaagccucuagcgaggacauacacggcccguaccccaaaccaacacagguggucagguagagaauacuaaggcguacgagugaacuaugguuaaggaacucggcaaaaugcccccguaacuucgggagaagggggacccacauggcguguaagccuuuacggcccaagcgugaguggguggcacaaaccagugagaagcgacuguuuacuaaaaacacagguccgugcgaagucgcaagacgauguauacggacugacgccugcccaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaacgacuucucaacugucucaaccauagacucggcgaaauugcacuacgaguaaagaugcucguuacgcgcggcaggacgaaaagaccccgggaccuucacuacaacuugguauuggugcucgauacgguuuguguaggauaggugggagacugugaagcucacacgccaguguggguggagucguuguugaaauaccacucugaucguauugggccucuaaccucggaccguauauccgguucagggacagugccugguggguaguuuaacuggggcgguugccuccuaaaauguaacggaggcgcccaaagguucccucaaccuggacggcaaucagguguugaguguaagugcacaagggagcuugacugcgagacggacaugucgagcagggacgaaagucgggacuagugauccggcaccucugaguggaaggggugucgcucaacggauaaaagguaccccggggauaacaggcugaucuuccccaagaguccauaucgacgggaugguuuggcaccucgaugucggcucgucgcauccuggggcuggagcaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguuuagaacgucgugagacaguucggucucuauccgccgcgcgcgucagaagcuugaggaaaccugucccuaguacgagaggaccgggacggacgaaccucugguauaccaguugucccaccaggggcacggcuggauagccacguucggacaggauaaccgcugaaagcaucuaagcgggaaaccucuuccaagaccaggcuucucacccucuaggagggauaaggccccccgcagaccacgggauugauagaccagaccuggaagccuaguaauaggugcagggaacuggcacuaaccggccgaaaacuuac <<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<<......<<<<<<.[[.(((.>>>.....<<<<<<<..<<<)))..]].>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<.....>>..<<<<<<.....<<.....>>....>>>>>>...<<<....<<<<<<<<<<...........<<......>>>>>>>>>>......<<<<.((.....<<<<<<..>>....>>>>>><<<<<<.......<<<<<<.<<<<.<<<.....<<<<......>>>>.(.......<<<......)>>>...>>>...>>>>>>>>>>>>>>>>.....).).>>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..>>>......>>.>>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<<<<..>>>>.>>>>>..>>>>...<.<........>.>.<<<<<<....<<<.<<<<<<<<<<..<<<...<<<....>>>...>>>...<<....>>..<<<<.....>>>>....<<<<<<<....>>>>>>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<....<<<<<<<<.....<<<....<<<.<<<<......<<<<....>>>>.......>>>>.>>>..>>.>.....>>>>>>>>.......>>>>>>>.>>..<<<<<<<<<<......>>>>>>.>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>...........)))......>>>>>>.>>>...>>>>>>><<<<<<<....>>>>>>>....>>>>>><.<<<<<<<<<<......<<<<<<<<....>>>.>>>>>...>>>>>>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<.......<<<<...<.......>.....>>>>.<<...<<<<<...<<<<..<<<..<<<<..<<<<<...((((...>>>>>.<<..<<<<...<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>...>>>>...>>...<<<......>>>.....>>>>...>>>...>>>>........>>>>>..>>....>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<<...<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<...<<<<....<<<.....>>>....>>>>..>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<........................<<<<.......>>>>...........>>>>>..>>.>>>>>>>.....>>.>>>>>>>>>>>>>>>.....>.((..<<<<<......))>>>>>..<<<<<<<<.<<<.<<......<<<<<<<<<<..<<<<<.<<<.<<<<<.<<.<<<<<<<<<<<..............<<<...<<<......<<<<..<......>..>>>>...>>>.............>>>.....>>>>>>>>>>>.>>...<<<.<<<<<<......>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.<<..>>>>..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<.<<<<...<<.......>>...>>>>.>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))))>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<...>>>>>....<<<<.<<<<.......>>>>.....<<<.<<<<.<<<....<<<<<....>>>>>...>>>..>>>>..>>>...>>>>....>>>>.. ((((......((((((((((.....(((..(((((((((((((......((((((.[[.[[[.))).....((((((...(((]]]..]].)))......))))))...)))....(((....)))(((((((......))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))....((([...(((((((((..........[[.[.......)))))))))....(.((((.((.....((((((..].]]..)))))).(((((.......((((((.((((.......(.(((........))))[[......(((.....]]))).........)))))))))))))))......).).))))]....(((((((...[.......)))))))....).(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((..(((((((((..)))).)))))..)))).<.(.(........).).((((((....(((.((((((((((..(((...(((....)))...)))...((....))..((((.....))))....(((((((....)))))))....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......A))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([.((((((((.....(((....(((.((((....(..(((....)))...)....)))).)))..)).).....))))))))....).]))))))).))..((((((((((......)))))).))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((.((((.......(((((.(.([.(((.........)))...)).....(]..(........).).)))))...)))).))))).))...........]]].)....))))))))))...)))))))((((((((..))))))))....))))))(.((((((((((......((((((((....))).)))))...))))))))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]]((((((((((.(......(((....(.....)......)))..((...(((((...((((..(((..((((..(((((....{{....))))).((..(((....(((((((((((.(.......)))))))).....))))..[.)))...))...(((......))).....))))...)))...))))(..)....)))))..))..).)))))))))))))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((...((((....((((..)])))....))))..))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.........................(((.......)))............))))...)).))))))).)..))).)))))))).)))))).....))[[..(((((.....>]])))))..((((((((.(((.((......((((((((((..(((((.(((.(((((.((.((.((((((((.............(..((...((......((.(..(......)..).))...)).............)).).....)))))))).)).))...(((.((((((......)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.(.((((...((.......))...)))).)...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))..a.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))..)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))..(((((...)))))....((((.((((.......)))).....(((.((((.(((....(((((....)))))...)))..))))..)))...))))....)))).. Structure of Mycobacterium smegmatis 50S ribosomal subunit bound to HflX:50S-HflX-B; 23S ribosomal RNA 8vk7 B 114 3.09 RF00001 39913204 0003735 0005840 246196 guuacggcgguccauagcggcagggaaacgcccggucccaucccgaacccggaagcuaagccugccagcgccgaugauacuacccauccggguggaaaaguaggacaccgccga ....<<<<<<<.....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<.......<<<<<<....>>>>>>.......>>..>>>>>>>. ....(((((((.....((((((((.........((...(.....)...))..........)))))).)).((.......((((((....)))))).......))..))))))). Structure of Mycobacterium smegmatis 50S ribosomal subunit bound to HflX:50S-HflX-B; 5S ribosomal RNA 8vki B 118 2.96 RF00001 39913204 0003735 0005840 246196 guuacggcgguccauagcggcagggaaacgcccggucccaucccgaacccggaagcuaagccugccagcgccgaugauacuacccauccggguggaaaaguaggacaccgccgaacac <<<.<<<<<<<.....<<<<<<<<.....<<<<<<.............>>>>..>>....>>>>>>.>>.<<.......<<<<<<....>>>>>>.......>>..>>>>>>>>>>.. (((.(((((((.....((((((((.....((((((...(.....)...))))..))....)))))).)).((.......((((((....)))))).......))..)))))))))).. Structure of Mycobacterium smegmatis 50S ribosomal subunit bound to HflX:50S-HflX-C; 5S ribosomal RNA 8vki A 2952 2.96 RF02540,RF02541,RF02543,RF00002 39913204 0003735 0005840 246196 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((((......((((((((((.....(((..(((((((((((((......((((((.[[.[[[.))).....((((((...(((]]]..]].)))......))))))...)))....(((....)))(((((((......))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))....((([...((((((((((..........[..[.....))))))))))....(.((((........(((.((.]...]..)).))).(((((.......((((((.((((.(((...(.((((......)))))[[(...).(((.....]])))...)))...)))))))))))))))..........))))]....(((((((...[.......)))))))....).(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((..(((((((((..)))).)))))..)))).<.(.(........).).((((((....(((.((((((((((..(((...(((....)))...)))...((....))..((((.....))))....(((((((....)))))))....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......A))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([.((((((((.....(((....(((.((((....(..(((....)))...)....)))).)))..)).).....))))))))....).]))))))).))..((((((((((......)))))).))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((.((((.......(((((.(((..(((.........)))..))).....(...((......)).).)))))...)))).))))).))...........]]].)....))))))))))...)))))))((((((((..))))))))....))))))(.((((((((((......((((((((....))).)))))...))))))))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]]((((((((((.(......(((.................)))..((...(((((...((((..(((..((((..(((((....{{....))))).((..(((....(((((((((((.((.....))))))))).....))))..[.)))...))...(((......))).....))))...)))...))))(..)....)))))..))..).)))))))))))))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((...((((....(((....])))....))))..))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((..........(...).....................................))))...)).))))))).)..))).)))))))).)))))).....))[[..(((((.....>]])))))..((((((((.(((.((......((((((((((..(((((.(((.(((((.(..((((....(((.................(...((.......(.(((((....))))).)....)).............)........)))....))))..)...(((.((((((......)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.(.((((...((.......))...)))).)...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))..a.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))..)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))..(((((...)))))....((((.((((.......)))).....(((.((((.(((....(((((....)))))...)))..))))..)))...))))....)))).. Structure of Mycobacterium smegmatis 50S ribosomal subunit bound to HflX:50S-HflX-C; 23S ribosomal RNA 8vkw A 3043 3.44 RF02540,RF02541,RF02543,RF00002 39913204 0003735 0005840 246196 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<<<<......<<<<<<<<<<<.....<<.<<<<<<<<<<<{<<......<<<<<<.[[.(((.>>>.....<<<<<<<..<<<)))..]].>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<.....>>..<<<<<<.....<<.....>>....>>>>>>...<<<....<<<<<<<<<<.........(((((.....>>>>>>>>>>......<<<<<.<.....<<<<<<<))))).>>>>>>><.<<<<.......<<<<<<.<<<<.<<<.....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>.>.....>.>.>>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..>>>......}.>>>>>>>>.>>>..............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<<<....>>>.>>>>>..>>>>...<.<........>.>.<<<<<<....<<<.<<<<<<<<<<..<<<...<<<....>>>...>>>...<<....>>..<<<<.....>>>>....<<<<<<<....>>>>>>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<....<<<<<<<<.....<<<....<<<.<<<<....<<<<........>>>.>....>>>>.>>>..>>.>.....>>>>>>>>.......>>>>>>>.>>..<<<<<<<<<<......>>>>>>.>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<..<.<..........<<.<....................................<........>....>.>>.....>.>...>>.>>...........)))......>>>>>>.>>>...>>>>>>><<<<<<<<..>>>>>>>>....>>>>>>..<<<<<<<<<<......<<<<<<<<....>>>.>>>>>...>>>>>>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<.......<<<<..<<<<..........<<<<.<<...<<<<<....<<<<<<........>>>>>>....>>>>>...>>.>>>>.........>>>>....>>>>.<<...<<<<<...<<<<..<<<..<<<<..<<<<<...((((...>>>>>.<<..<<<<...<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>...>>>>...>>.<.<<<......>>>..>..>>>>...>>>...>>>>........>>>>>..>>....>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<<...<<<<<<<<.<<...............<<<<<....<....>.....>>>>><<<<<<...<<<<....<<<.....>>>....>>>>..>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<..<.....<<<<<.<<<<<<...>>>>>>..>>>>>.....>..>>>>>>>>>..>>>>><<..<<.......>>..>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>>>>>>>>.....>.((..<<<<<......))>>>>>..<<<<<<<<.<<<.<<......<<<<<<<<<<..<<<<<.<<<.<<<<<.<<.<<<<<<<<<....>>>>>>>>>.>>...<<<.<<<<<<......>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.<<..>>>>..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<.<<<<...<<.......>>...>>>>.>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))))>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<...>>>>>....<<<<.<<<<.......>>>>.....<<<.<<<<.<<<....<<<<<....>>>>>...>>>..>>>>..>>>...>>>>....>>>>.. ((((.......(((((((((.....(((..(((((((((((((......((((((.[[.[[[.))).....((((((...(((]]]..]].)))......))))))...)))....(((....)))(((((((......))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))....((([...((.(((.(((..........[.[[.....))).))).))....(.(((((.(.....((((((.]].]...)))))).(((((.......((((((.((((.(((...(.((((......)))))[[(...).(((.....]])))...)))...)))))))))))))))......).).))))]....(((((((...[.......)))))))....).(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(...(((....))).............)).....)))))))))......(.((((..(((((((((..)))).)))))..)))).<.(.(........).).((((((..(.(((.((((((((((..(((...(((....)))...)))...((....))..((((.....))))....(((((((....)))))))....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......A))))))))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))(((((((((.([.((((((((.....(((....(((.((((....((.(........).).)....)))).)))..)).).....))))))))....).]))))))).))..((((((((((......)))))).))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((..(.(..(.....{.((.....(.....(.........).....)......(....(......)..)....))...).).)...)).))...........]]].)....))))))))))...)))))))((((((((..))))))))....))))))(.((((((((((......((((((((....))).)))))...))))))))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]]((((((((((.(.....(((...(.(...........((((.((...(((((....(((((((......)))))))....)))).)..)).))))..........).).....))).((...(((((...((((..(((..((((..(((((....{{....))))).((..(((....(((((((((((.((.....))))))))).....))))..[.)))...))...(((......))).....))))...)))...))))(..)....)))))..))..).)))))))))))))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((...(((.....(((....]))).....)))..))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((....((((..((((((...))))))...)))).....))..))))))))..)))))(.................)........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....))[[..(((((.....>]])))))..((((((((.(((.((......((((((((((..(((((.(((.(((((.((.((.((((((....)))))).)).))...(((.((((((......)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....((.((((.((..]]]]..)))))).)).....)}......))))..))))))......(((((.(.(.((((...((.......))...)))).)...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..a.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..(((((...)))))....((((.((((.......)))).....(((.((((.(((....(((((....)))))...)))..))))..)))...))))....)))).. Structure of Mycobacterium smegmatis 50S ribosomal subunit bound to delNTE-HflX; 23S ribosomal RNA 8vkw B 118 3.44 RF00001 39913204 0003735 0005840 246196 guuacggcgguccauagcggcagggaaacgcccggucccaucccgaacccggaagcuaagccugccagcgccgaugauacuacccauccggguggaaaaguaggacaccgccgaacac <<....<<<<<.....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<.......<<<<<<....>>>>>>.......>>..>>>>>...>>.. ((..((.(.(......(((((((.(....((((((...(.....)...))))..))....)))))).)).((.......((((((....)))))).......))....))).).)).. Structure of Mycobacterium smegmatis 50S ribosomal subunit bound to delNTE-HflX; 5S ribosomal RNA 8vr4 B 118 2.8 RF00001 39913204 0003735 0005840 246196 guuacggcgguccauagcggcagggaaacgcccggucccaucccgaacccggaagcuaagccugccagcgccgaugauacuacccauccggguggaaaaguaggacaccgccgaacac <<<.<<<<<<<.....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<.......<<<<<<....>>>>>>.......>>..>>>>>>>>>>.. (((.(((((((.....(((((((.(....((((((...(.....)...))))..))....)))))).)).((.......((((((....)))))).......))..)))))))))).. Structure of Mycobacterium smegmatis 50S ribosomal subunit bound to HflX and erythromycin:50S-HflX-A-Ery; 5S ribosomal RNA 8vr4 A 3118 2.8 RF02540,RF02541,RF02543,RF00002 39913204 0003735 0005840 246196 aaguguuuaagggcgcaugguggaugccuuggcacugggagccgaugaaggacguaggaggcugcgauaagccucggggagcugucaaccgagcguugauccgaggauguccgaauggggaaacccggcacgagugaugucgugucaccaggcgcugaauauauaggcgucuggggggaacgcggggaagugaaacaucucaguacccguaggaagagaaaacaaaaugugauuccgugaguaguggcgagcgaaagcggaggauggcuaaaccguaugcaugugauaccggguagggguugugugugcgggguugugggaccuaucuuuccggcucuaccuggcuggagggcagugagaaaauguugugguuagcggaaauggcuugggauggccugccguagacggugagagcccgguacgugaaaacccgacgucugucuugaugguguucccgaguagcagcgggcccguggaaucugcugugaaucugccgggaccacccgguaagccugaauacuucccagugaccgauagcggauuaguaccgugagggaauggugaaaaguaccccgggaggggagugaaagaguaccugaaaccgugcgcuuacaauccgucagagcccucgacgugucguggggugauggcgugccuuuugaagaaugagccugcgagucagggacaugucgcgagguuaacccgggugggguagccgcagcgaaagcgagucugaauagggcguauccacacaagagugugugguguagugguguguucuggacccgaagcggagugaucuacccauggccagggugaagcgcggguaagaccgcguggaggcccgaacccacuuagguugaagacugaggggaugagcuguggguaggggugaaaggccaaucaaacuccgugauagcugguucuccccgaaaugcauuuaggugcagcgucgcauguuucuugccggagguagagcuacuggauggccgaugggccccacaggguuacugacgucagccaaacuccgaaugccgguaaguccaagagugcggcagugagacggcgggggauaagcuccgugcgucgagagggaaacagcccagaucgccggcuaaggccccuaagcgugugcuaaguggaaaaggaugugcagucgcgaagacaaccaggagguuggcuuagaagcagccacccuugaaagagugcguaauagcucacuggucaagugauugugcgccgauaauguagcggggcucaagcacaccgccgaagccgcggcagccaacguguuggcuggguaggggagcguccugcauccggugaagccgccgagugaucgagugguggagggugugggagugagaaugcaggcaugaguagcgauuaggcaagugagaaccuugcccgccgaaagaccaaggguuccugggccaggccaguccgcccagggugagucgggaccuaaggcgaggccgacaggcguagucgauggacaacggguugauauucccguacccguguaugugcguccaugaugaaucagcgguacuaaccauccaaaaccaccgugaccgcaccuuucgggguguggcguugguggggcugcaugggaccuucguugguaguagucaagcgauggggugacgcaggaagguagccguaccggucagugguaauaccgggguaagccuguagggagucagauagguaaauccgucuggcauauauccugagaggugaugcauagccgagugaggcgaauucggugauccuaugcugccgagaaaagccucuagcgggacauacacggcccguaccccaaaccaacacagguggucagguagagaauacuaaggcguacgagugaacuaugguuaaggaacucggcaaaaugcccccguaacuucgggagaagggggacccacauggcguguaagccuuuacggcccaagcgugaguggguggcacaaaccagugagaagcgacuguuuacuaaaaacacagguccgugcgaagucgcaagacgauguauacggacugacgccugcccggugcuggaagguuaagaggacccguuaacucccuuugggggugaagcggagaauuuaagccccaguaaacggcggugguaacuauaaccauccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaacgacuucucaacugucucaaccauagacucggcgaaauugcacuacgaguaaagaugcucguuacgcgcggcaggacgaaaagaccccgggaccuucacuacaacuugguauuggugcucgauacgguuuguguaggauaggugggagacugugaagcucacacgccaguguggguggagucguuguugaaauaccacucugaucguauugggccucuaaccucggaccguauauccgguucagggacagugccugguggguaguuuaacuggggcgguugccuccuaaaauguaacggaggcgcccaaagguucccucaaccuggacggcaaucagguguugaguguaagugcacaagggagcuugacugcgagacggacaugucgagcagggacgaaagucgggacuagugauccggcaccucugaguggaaggggugucgcucaacggauaaaagguaccccggggauaacaggcugaucuuccccaagaguccauaucgacgggaugguuuggcaccucgaugucggcucgucgcauccuggggcuggagcaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguuuagaacgucgugagacaguucggucucuauccgccgcgcgcgucagaagcuugaggaaaccugucccuaguacgagaggaccgggacggacgaaccucugguauaccaguugucccaccaggggcacggcuggauagccacguucggacaggauaaccgcugaaagcaucuaagcgggaaaccucuuccaagaccaggcuucucacccucuaggagggauaaggccccccgcagaccacgggauugauagaccagaccuggaagccuaguaauaggugcagggaacuggcacuaaccggccgaaaacuuac <<<<......<<<<<<<<<<<.....<<.<<<<<<<<<<<<<<......<<<<<<.[[.(((.>>>.....<<<<<<<..<<<)))..]].>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<.....>>..<<<<<<.....<<.....>>....>>>>>>..........<<<<<<<.............<<..........>>>>>>>.......((((.[.....<<<<<<<..>>..>>>>>>><<<<<<........<<<<<.<<<<.<<<.....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>.>>>>>>.....].)).))......<<<<<<<<.........>>>>>>>>......<<<<<..[..[>>>>>...........>.>>>>>>>>.>>>..............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<<<<..>>>>.>>>>>..>>>>...<.<........>.>.<<<<<<....<<<.<<<<<<<<<<..<<<...<<<....>>>...>>>...<<....>>..<<<<.....>>>>....<<<<<<<....>>>>>>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<....<<<<<<<<.....<<<....<<<.<<<<....<.<<<......>>>..>....>>>>.>>>..>>.>.....>>>>>>>>.......>>>>>>>.>>..<<<<<<<<<<......>>>>>>.>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<.<.<..........<<.<<.......<...........>................<......>....>>.>>.....>.>..>>>.>>...........)))......>>>>>>.>>>...>>>>>>><<<<<<<<..>>>>>>>>....>>>>>>..<<<<<<<<<<......<<<<<<<<....>>>.>>>>>...>>>>>>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<.......<<<<..<<<...........<<<<.<....<<<<<......<<<<........>>>>......>>>>>....>.>>>>..........>>>....>>>>.<<...<<<.....<<<<..<<<..<<<<..<<<<<...((((...>>>>>.<<..<<<<...<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>...>>>>...>>...<<<......>>>.....>>>>...>>>...>>>>.........>>>...>>...>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<<...<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<...<<<<....<<<.....>>>....>>>>..>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<.....<<<<<.<<<<<<...>>>>>>..>>>>>.....>...>>>>>>>>..>>>>><<<<<.........>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>>>>>>>>.....>.((..<<<<<......))>>>>>..<<<<<<<<.<<<.<<......<<<<<<<<<<..<<<<<..<..<.....<..<<<<<<<<<...............................<<.<<.<<....>>.>>.>>.............................>>>>>>>>>.>....<<<.<<<<<<......>>>>>>>>>.......>..>....>>>>>..<<<<.....>>>><<<<<<...........>>>>>>.......<<<<<<<...<<...............>>.....<<.[.(((>>....>>>>>>>....<<<..<<<......>>>..>>>.<<.......>>...)))]......<<<<<<<.<<..].]...>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<.<<<<...<<.......>>...>>>>.>....>>>.>.......<<<<<.<<<<<<..<<<.<<<<<......>>>>>...>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))))>>>>>>..>>>>>...>>>>.>>>>>...<<<....<..<.............>.>.....>>>.>>>>.......>>>>>>>..<<<<<...>>>>>....<<<<.<<<<.......>>>>.....<<<.<<<<.<<<....<<<<<....>>>>>...>>>..>>>>..>>>...>>>>....>>>>.. ((((......((((((((((.....(((..(((((((((((((......((((((.[[.[[[.))).....((((((...(((]]]..]].)))......))))))...)))....(((....)))((..((........))..)).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))....((.....((((((..(..........[[..[......)..))))))......(.(..((.....((((((.]...]].)))))).(((((.......((((((.((((.(((...(.((((......)))))[[(...).(((.....]])))...)))...)))))))))))))))......).)..))......(((((((...[.......))))))).......((((].[..[))))....))......)).))))))).))...............((....))....))......(...(((....))).............)).....)))))))))).....(.((((..(((((((((..)))).)))))..)))).<.(.(........).).((((((..(.(((.((((((((((..(((...(((....)))...)))...((....))..((((.....))))....(((((((....)))))))....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......A))))))))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))(((((((((.([.((((((((.....(((....((..((((....(..(........)...)....))))..))..)).).....))))))))....).]))))))).))..((((((((((......)))))).))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((..(.(........{..(..(.......(...........)...........(....(......)..).)..)......).)...)).))...........]]].)....))))))))))...)))))))((((((((..))))))))....))))))(.((((((((((......((((((((....))).)))))...))))))))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]]((((((((((.......((((..(.(...........((((.(....(((((....((..((........))..))....)))))....).))))..........).)....)))).((...(((.(...((((..(((..((((..(((((....{{....))))).((..(((....(((((((((((.((.....))))))))).....))))..[.)))...))...(((......))).....))))...)))...))))(..)....))).)..))...)))))))))))))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((...((((....(((....])))....))))..))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((...((.........((((..(((((.....)))))...)))).........)).)))))..)))))(.................)........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....))[[..(((((.....>]])))))..((((((((.(((.((......((((((((((..(((((.((..(..(..(..(((((((((.(.(.(..........................(.(((((....))))).)........................)..)).))))))))).)....(((.((((((......))))))))).....).)..).)..)))))..(((......[)))((((((..........]))))))([(....(((((((...((...............)).....((][.[[[))....))))))).....((..(((...{..)))..))..(.((....)))..)]]].].....((.((((.((..].]...)))))).)).....)}......))))..))))))......(((((.(.(.((((...((.......))...)))).)...)))).).)......((((.((((((..(..(.((((......))))).....).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..a.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))..)))))...)))).)))))...(((....(..(.....}.......).).....))).))))..]....)))))))..(((((...)))))....((((.((((.......)))).....(((.((((.(((....(((((....)))))...)))..))))..)))...))))....)))).. Structure of Mycobacterium smegmatis 50S ribosomal subunit bound to HflX and erythromycin:50S-HflX-A-Ery; 23S ribosomal RNA 8vr8 B 118 3.25 RF00001 39913204 0003735 0005840 246196 guuacggcgguccauagcggcagggaaacgcccggucccaucccgaacccggaagcuaagccugccagcgccgaugauacuacccauccggguggaaaaguaggacaccgccgaacac <<<.<<<<<<<.....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<.......<<<<<<....>>>>>>.......>>..>>>>>>>>>>.. (((.(((((((.....((((((((.....((((((...(.....)...))))..))....)))))).)).((.......((((((....)))))).......))..)))))))))).. Structure of Mycobacterium smegmatis 50S ribosomal subunit bound to HflX and chloramphenicol:50S-HflX-B-Clm; 5S ribosomal RNA 8vr8 A 2950 3.25 RF02540,RF02541,RF02543,RF00002 39913204 0003735 0005840 246196 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Structure of Mycobacterium smegmatis 50S ribosomal subunit bound to HflX and chloramphenicol:50S-HflX-B-Clm; 23S ribosomal RNA 8vrl B 118 3.33 RF00001 39913204 0003735 0005840 246196 guuacggcgguccauagcggcagggaaacgcccggucccaucccgaacccggaagcuaagccugccagcgccgaugauacuacccauccggguggaaaaguaggacaccgccgaacac <...<<<<<<<.....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<.......<<<<<<....>>>>>>.......>>..>>>>>>>..>.. (...((.((((.....((((((((.....((((((...(.....)...))))..))....)))))).)).((.......((((((....)))))).......))..))))).)..).. Structure of Mycobacterium smegmatis 50S ribosomal subunit bound to HflX and chloramphenicol:50S-HflX-A-Clm; 5S ribosomal RNA 8vrl A 3119 3.33 RF02540,RF02541,RF02543,RF00002 39913204 0003735 0005840 246196 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<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<<......<<<<<<.[[.(((.>>>.....<<<<<<<..<<<)))..]].>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<.....>>..<<<<<<.....<<.....>>....>>>>>>...<<<....<<<<<<.<<<.........(((((.....>>>.>>>>>>......<<<<<.......<<<<<<<))))).>>>>>>><<<<<<.......<<<<<<.<<<<.<<<.....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>>>.......>.>>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..>>>......>>.>>>>>>>.>>...............<<....>>....>>..........<<<....>>>...................>>>>>>>>>>>.......<<<<..<<<<<<<<....>>>.>>>>>..>>>>...<.<........>.>.<<<<<<....<<<.<<<<<<<<<<..<<<...<<<....>>>...>>>...<<....>>..<<<<.....>>>>....<<<<<<<....>>>>>>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<....<<<<<<<<.....<<<....<<<.<<<<....<<<..........>>.>....>>>>.>>>..>>.>.....>>>>>>>>.......>>>>>>>.>>..<<<<<<<<<<......>>>>>>.>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<.<.<..........<<..........<...........>...............<<......>>......>>.....>.>..>>>.>>...........)))......>>>>>>.>>>...>>>>>>><<<<<<<<..>>>>>>>>....>>>>>><.<<<<<<<<<<......<<<<<<<<....>>>.>>>>>...>>>>>>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<.......<<<<...<<<..........<<<<.<<...<<<<<....<<<<<<.<.....>>>>>>>....>>>>>...>>.>>>>.........>>>.....>>>>.<<...<<<<<...<<<<..<<<..<<<<..<<<<<...((((...>>>>>.<<..<<<<...<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>...>>>>...>>...<<<......>>>.....>>>>...>>>...>>>>........>>>>>..>>....>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<<...<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<...<<<<....<<<.....>>>....>>>>..>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<..<<....<<<<..<<<<<<...>>>>>>...>>>>....>>..>>>>>>>>>..>>>>>.<..<<.......>>..>.........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>>>>>>>>.....>.((..<<<<<......))>>>>>..<<<<<<<<.<<<.<<......<<<<<<<<<<..<<<<<.<<<.<<<<<.<<.<<<.<<<<<<<<<.............<.............<<<<<.<<....>>.>>>>>....................>....>>>>>>>>>.>>>.>>...<<<.<<<<<<......>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.<<..>>>>..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<.<<<<...<<.......>>...>>>>.>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))))>>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<...........>>>>>...>>>>.>>>>.......>>>>>>>..<<<<<...>>>>>....<<<<.<<<<.......>>>>.....<<<.<<<<.<<<....<<<<<....>>>>>...>>>..>>>>..>>>...>>>>....>>>>.. ((((.......(((((((((.....(((..(((((((((((((......((((((.[[.[[[.))).....((((((...(((]]]..]].)))......))))))...)))....(((....)))(((((((......))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))....((([...((((((.(((..........[.[[.....))).))))))....(.(((((.(.....((((((.]].]...)))))).(((((.......((((((.((((.(((...(.((((......)))))[[(...).(((.....]])))...)))...)))))))))))))))......).).))))]....(((((((...[.......)))))))....).(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(...(((....))).............)).....)))))))))......(.((((..(((((((((..)))).)))))..)))).<.(.(........).).((((((..(.(((.((((((((((..(((...(((....)))...)))...((....))..((((.....))))....(((((((....)))))))....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......A))))))))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))(((((((((.([.((((((((.....(((....(((.((((....(.((........))..)....)))).)))..)).).....))))))))....).]))))))).))..((((((((((......)))))).))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((..(.(..(.....{.((.....(.....(.........).....)......(...((......).))....))...).).)...)).))...........]]].)....))))))))))...)))))))((((((((..))))))))....))))))(.((((((((((......((((((((....))).)))))...))))))))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]]((((((((((.(.....(((...(.(...........((((.((...(((((....((((((........))))))....)))).)..)).))))..........).).....))).((...(((((...((((..(((..((((..(((((....{{....))))).((..(((....(((((((((((.((.....))))))))).....))))..[.)))...))...(((......))).....))))...)))...))))(..)....)))))..))..).)))))))))))))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((...((((....(((....])))....))))..))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..((....((....((((..((((((...))))))...))))....))....)))))))..)))))((...............))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....))[[..(((((.....>]])))))..((((((((.(((.((......((((((((((..(((((.(((.(((((.((.((((.((((.((..(................(.........(.(.(((....))).).)......).................)..)).)))).)))).))...(((.((((((......)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.(.((((...((.......))...)))).)...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..a.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..(((((...)))))....((((.((((.......)))).....(((.((((.(((....(((((....)))))...)))..))))..)))...))))....)))).. Structure of Mycobacterium smegmatis 50S ribosomal subunit bound to HflX and chloramphenicol:50S-HflX-A-Clm; 23S ribosomal RNA 8vs9 16S 1539 3.9 RF01959,RF00177,RF02542,RF01960 38500588 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<..<....>..>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<.......<<<....>>>......>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<.<.<<<......>>>.....>>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.<.....<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<<..<<<.....>>>>>.....>>>>>>.....<<<<<.....>>>>>........>>>>.....>...>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((.((...(....)...))..)))))..)))))......(((......(((((((..((...((((.((.(.((.....((((.(....).))))......)).).....(((....))).....(((((..((....)))))))..)).))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((.(.........)))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..(((.......(.((....)).)......)))...(.(((((...(....((((((((.......)))))))).....)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......(((.((.....)).)))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((.((((.....)))).)))))))...((..]])).....)))))))))).(((......(.((....)).)....)))...]]].]((((..(((((.(.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...((((((....)))))).....(....)...))))).))).((.((....((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(.(((((...((..(((.....)))))....)))).))..(..(((((.....))))).....)..)))).....).).)))...))..))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...).))))).)).))..(.(..((.(.((((.(((..(((.((((((((....(((.(..((((..((....)).)))).).)))...)))))))).)))..))).))))..).))...)..)..(((((((((....)))))))))}........... Endogenous trans-translation complex with tmRNA*SmpB in the P site and alanyl-tRNA in the A site and deacyl-tRNA in the E site of E. coli 70S ribosome; 16S ribosomal RNA 8vs9 23S 2903 3.9 RF02541 38500588 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugucgaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<.......>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<......<.<<<<<.<<<...<<.........>>...>>>........<<<......>>>..>>>>>.>..>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<......>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<....<....>.....>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<..<<<.<<<<<.<<<<<<<<<<<.<<<............<<<<<..<<<......<<<<.<<......>>.>>>>...>>>............>>>>>...>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>...>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......(((((..[..[[[..)).....((.(((...(((]]]..].))).......))).))...)))....(((....)))((((((......)))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......((((.((((((((.(((...(((((......)))))[[......(((.....]])))...)))...)))))))).))))...))))...)....((.(((((..[......))))).))......((.((].[[[[)).))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..))))...(.(........).).((((((....(((((((((((((..((....((.....))....))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....(((((.((((.(((....((((.(......).))))....[)))...(((.(((((........))))))))..).))).))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((.(((.......)))..))...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(.(((..(((.....{.(((((.(((...((.........))...))).....(..(((......)))).)))))...)))..))).).))...........]]].)...))))))))))...)))))))((((((.(......).))))))....))))))(.(((((...(((.......((.(((......))).))....)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((.(((((((((...((((....((((..(((..(((((((((((....{{....))))))(....(((...(((((.((((((.((.....)))))))).)..))))..[))).....)(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))).))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....((....((((....]))))....))...))))))(...).......(((((..((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........((.((..((....))...)).))........))))))))..)))))(.(.(.........).).)........((..........(((((.......)))))..)..)....))))...))...))))).)..))).)))))))).)))))).....)).[..(((((......].)))))..((((((((.(((.((......((((.((((.(..((((..((..(((((.((((((..(((.(((..(..........((.(..((........((..((......))..)).....))............).)).)..))).)))..))))))...(((..(((((.....))))).)))....)))))..))...))))..(((......[)))((((((..........]))))))([((....(.((((...(.(((.........)).)).....((][.[[[))....)))).)....((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......).))..))))))......(((((.(.(((((.(..((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..((.((((.....(....)....)))).)).(((((...((((...(((((((((((.}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..(.....(((((....)))))....)...))))).))).....))..).))))))))). Endogenous trans-translation complex with tmRNA*SmpB in the P site and alanyl-tRNA in the A site and deacyl-tRNA in the E site of E. coli 70S ribosome; 23S ribosomal RNA 8vs9 5S 120 3.9 RF00001 38500588 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.....<.<<<<<<<<...>>>>>>>>...>...>>...>>>>>>>>>>. ((((((((((.....((.(((((....(((((((...(.....)...))))..)))...)))))..)).((.......((((((((...)))))))).......))...)))))))))). Endogenous trans-translation complex with tmRNA*SmpB in the P site and alanyl-tRNA in the A site and deacyl-tRNA in the E site of E. coli 70S ribosome; 5S ribosomal RNA 8vs9 ATRN 76 3.9 RF00005 URS00005F0912_562 38500588 0030533 0006412 562 ggggcuauagcucagcugggagagcgccugcuuugcacgcaggaggucugcgguucgaucccgcauagcuccacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... ((.((((..((((.....[..)))).(((((.......))))).....(((((..]....))))))))).)).... Endogenous trans-translation complex with tmRNA*SmpB in the P site and alanyl-tRNA in the A site and deacyl-tRNA in the E site of E. coli 70S ribosome; A-tRNA 8vs9 ETRN 77 3.9 RF00005 38500588 0030533 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(.(((..]....))).)))))))..... Endogenous trans-translation complex with tmRNA*SmpB in the P site and alanyl-tRNA in the A site and deacyl-tRNA in the E site of E. coli 70S ribosome; E-tRNA 8vs9 TMRN 363 3.9 RF00023 URS000037602E_562 38500588 0006401 562 ggggcugauucuggauucgacgggauuugcgaaacccaaggugcaugccgaggggcgguuggccucguaaaaagccgcaaaaaauagucgcaaacgacgaaaacuacgcuuuagcagcuuaauaaccugcuuagagcccucucucccuagccuccgcucuuaggacggggaucaagagaggucaaacccaaaagagaucgcguggaagcccugccugggguugaagcguuaaaacuuaaucaggcuaguuuguuaguggcguguccguccgcagcuggcaagcgaauguaaagacugacuaagcauguaguaccgaggauguaggaauuucggacgcggguucaacucccgccagcuccacca <<<<<<<.............<<<<<<<<.......<...<<<..<<<<......<<<<<..............>>>>>.............................<<<<<<<<<<.........>>>>.>>>>>><<<<<<<<<<<.......[(((((.....>>>>....>>>>>>>..........))))).].<<<.....<<<...((...>>>.....>>>.............))......<<<<....<<...((.....>>....>>>>................))....>>>>.....>>>...>......>>>>>>>>.....<<<.......>>>..>>>>>>>.... (((((((......[......((..((((.......(...((...((((.[.[..((((....]..]........)))).............................((((((.(((.........)))..))))))((((((.(((....(....[[[[[.)....))).....))))))..........]]]]]....((....((((...[[[..))))....)).............]]].......((...(.(....[[......))....)).................]]....))))......))...)......))))..)).....(((..]....)))..))))))).... Endogenous trans-translation complex with tmRNA*SmpB in the P site and alanyl-tRNA in the A site and deacyl-tRNA in the E site of E. coli 70S ribosome; TMRN 8vsa 23S 2903 3.7 RF02541 38500588 0003735 0005840 562 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<<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<.......>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<......<.<<<<<.<<....<<.........>>....>>........<<<......>>>..>>>>>.>..>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<......>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<..<<<.<<<<<.<<<<<<<<<<<.<<<............<<<<...<<.......<<<<.<<<....>>>.>>>>....>>.............>>>>..>.>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>...>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))((((((......)))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[......(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..((....((.....))....))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.(((....((((.(......).))))....[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((.(((.......)))..))...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(.(.....{.(((((.(((...((.........))...))).....(..(((......)))).)))))...).)..))))).))...........]]].)...))))))))))...)))))))((((((.(......).))))))....))))))(.(((((...(((......(((.(((......))).)))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]]((((((((((.((...((((....((((..(((..(((((((((((....{{{...))))))(...((((....(((((((((((.((.....))))))))))..)))...[))))....)(..(.(((....))).)...))))))...)))...))))(..).....))))...)).....)))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....((.....(((....]))).....))...))))))(...).......(((((.(((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(.(((.........))).)........((..........(((((.......)))))..)..)....))))...)).).))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((.(..(((((.((..(((((.((((((.((((.((..............((.(...(........((...((....))...)).....).............).)).....)).)))).))))))...(((..(((((.....))))).)))....)))))..))..)))))..(((......[)))((((((..........]))))))([((....(.((((...(.(((.........)).)).....((][.[[[))....)))).)....((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......).))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..((.((((.....(....)....)))).)).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..(.....(((((....)))))....)...))))).))).....))..).))))))))). Endogenous trans-translation complex with tmRNA*SmpB in the P site and alanyl-tRNA in the A site of E. coli 70S ribosome; 23S ribosomal RNA 8vsa 5S 120 3.7 RF00001 38500588 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<...<.<.<<<<<<<<...>>>>>>>>...>.>.>>...>>>>>>>>>>. ((((((((((.....((.(((((....(((((((...(.....)...))))..)))...)))))..)).((.......((((((((...)))))))).......))...)))))))))). Endogenous trans-translation complex with tmRNA*SmpB in the P site and alanyl-tRNA in the A site of E. coli 70S ribosome; 5S ribosomal RNA 8vsa TMRN 363 3.7 RF00023 URS000037602E_562 38500588 0006401 562 ggggcugauucuggauucgacgggauuugcgaaacccaaggugcaugccgaggggcgguuggccucguaaaaagccgcaaaaaauagucgcaaacgacgaaaacuacgcuuuagcagcuuaauaaccugcuuagagcccucucucccuagccuccgcucuuaggacggggaucaagagaggucaaacccaaaagagaucgcguggaagcccugccugggguugaagcguuaaaacuuaaucaggcuaguuuguuaguggcguguccguccgcagcuggcaagcgaauguaaagacugacuaagcauguaguaccgaggauguaggaauuucggacgcggguucaacucccgccagcuccacca <<<<<<<.............<<<<<<<<.......<<..<<<..<<<<.......<<<................>>>..............................<<<<<<<<<<.........>>>>.>>>>>><<<<<<.<<<<.......[.((((.....>>>>.....>>>>>>..........))))..].((((....(((...<<<<<)))....))))..........>>>>>......<<<<....<<...((..(..>>....>>>>.............)..))....>>>>.....>>>..>>......>>>>>>>>.....<<<.......>>>..>>>>>>>.... (((((((......[.......(.(((((.......(...((...((((.[.....(((.......]........)))..............................((((((.(((.........)))..))))))(.((((.(((....(...[..[[[.)....))).....)))).)..........]]]...]..((.....(((...[[...))).....))..............]].......(....(.(....[[......)).....).................]]....))))......))...)......))))).)......(((..]....)))..))))))).... Endogenous trans-translation complex with tmRNA*SmpB in the P site and alanyl-tRNA in the A site of E. coli 70S ribosome; TMRN 8vsa 16S 1539 3.7 RF01959,RF00177,RF02542,RF01960 38500588 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<.<....>.>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<.......<<<....>>>......>>>>..<<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>>.<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<.<.<<<......>>>.....>>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<<..<<<.....>>>>>.....>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>.........<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((.((...(....)...))..)))))..)))))......(((......(((((((..((...((((.((.(.((.....((((..(...).))))......)).).....(((....))).....(((((..((....)))))))..)).))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((.(.........)))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(...(((((((((.......)))))))).)...)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(.(((((.(((((((((.......((((((.....)))))).....)))))))..))))))).)..(((((((((....(((((((....(((((((...((........))......)))))))....).......((....)).))))))...))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((.((((.....)))).)))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...((.(((....))).)).....(....)...))))).))).((.(((...((((((.(....((.((((((....)))...(((......)))...))).)).....((((.((.((((...((..(((.....)))))....)))).))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(.(((((.....(((..((...(((....)))...))....))).....))))).)......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Endogenous trans-translation complex with tmRNA*SmpB in the P site and alanyl-tRNA in the A site of E. coli 70S ribosome; 16S ribosomal RNA 8vsa ATRN 76 3.7 RF00005 URS00005F0912_562 38500588 0030533 0006412 562 ggggcuauagcucagcugggagagcgccugcuuugcacgcaggaggucugcgguucgaucccgcauagcuccacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... ((.((((..((((.....[..)))).(((((.......))))).....((.((..]....)).)))))).)).... Endogenous trans-translation complex with tmRNA*SmpB in the P site and alanyl-tRNA in the A site of E. coli 70S ribosome; A-tRNA 8vtu 1A 2871 2.4 RF02541 39039256 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<....<<<<........>>>..>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..<<<.......>>>...>>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<.......<<<<<<<....>>>>>>>....>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((..(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...((((((((....(((..........)..))...))))))))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((..((.........))...))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((..((((((((.(.........(((((..(((.......(((((((....)))))))....)))............)))))).))))))))..))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..(((...)))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with macrolone MCX-66, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.40A resolution; 23S Ribosomal RNA 8vtu 1B 120 2.4 RF00001 39039256 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> (((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).))))))))))) Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with macrolone MCX-66, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.40A resolution; 5S Ribosomal RNA 8vtu 1a 1500 2.4 RF00177,RF01959,RF02542,RF01960 39039256 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<......>>....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((..)))))))).)))))......(((......((((((((..((...(((((((.(((((....((((.(....).)))).....)))))....((((..((((....))))..))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((.(((....))).)))....(((....)))....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with macrolone MCX-66, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.40A resolution; 16S Ribosomal RNA 8vtu 1v 13 2.4 39039256 10665 aaaaauguucuaa ............. ............. Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with macrolone MCX-66, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.40A resolution; MF-mRNA 8vtu 1w 74 2.4 RF00005 39039256 0030533 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcaccn <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[..)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with macrolone MCX-66, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.40A resolution; Aminoacylated Phe-tRNAphe 8vtu 1x 77 2.4 RF00005 URS000041AF00_562 39039256 0030533 0006412 562 cgcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaaccn .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with macrolone MCX-66, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.40A resolution; Aminoacylated fMet-tRNAmet 8vtu 1y 74 2.4 RF00005 39039256 0030533 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((......)))).((((.........)))).....(((((.......)))))))))))).... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with macrolone MCX-66, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.40A resolution; Deacylated tRNAphe 8vtu 2A 2800 2.4 RF02541 39039256 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<....<<............>.>....>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<..>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((()))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((....((............).)....)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((.().)))))))).))..........]]].)....))))))))))...)))))))(((((((())))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........(((((..(((......((((((((....))))))))...)))............)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.((.))......(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with macrolone MCX-66, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.40A resolution; 23S Ribosomal RNA 8vtu 2B 120 2.4 RF00001 39039256 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with macrolone MCX-66, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.40A resolution; 5S Ribosomal RNA 8vtu 2a 1503 2.4 RF00177,RF01959,RF02542,RF01960 39039256 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggau .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<......>>....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((.(....).)))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((((((....)))))))....(.(....).)....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.(.((....)).)).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with macrolone MCX-66, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.40A resolution; 16S Ribosomal RNA 8vtu 2v 13 2.4 39039256 10665 aaaaauguucuaa ............. ............. Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with macrolone MCX-66, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.40A resolution; MF-mRNA 8vtu 2w 72 2.4 RF00005 39039256 0030533 562 cccgganagcucagggagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcaccn <<<<<<..<<<<.....>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((...[.)))).((((.........)))).....(((((..]....)))))))))))..... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with macrolone MCX-66, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.40A resolution; Aminoacylated Phe-tRNAphe 8vtu 2x 77 2.4 RF00005 URS000041AF00_562 39039256 0030533 0006412 562 cgcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaaccn .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with macrolone MCX-66, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.40A resolution; Aminoacylated fMet-tRNAmet 8vtu 2y 73 2.4 RF00005 39039256 0030533 562 gcccgganagcucagggagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<.....>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[.)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with macrolone MCX-66, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.40A resolution; Deacylated tRNAphe 8vtv 1A 2871 2.55 RF02541 39039256 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<....<<<<........>>>.>....>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..<<.........>>...>>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<.......<<<<<<<....>>>>>>>....>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((..(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((.(..(((..........))..))..)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((..((.........))...))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(......[..(((((..(((......((((((((....))))))))...)))..........].)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..((((.))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with macrolone MCX-91, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.55A resolution; 23S Ribosomal RNA 8vtv 1B 120 2.55 RF00001 39039256 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> (((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).))))))))))) Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with macrolone MCX-91, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.55A resolution; 5S Ribosomal RNA 8vtv 1a 1500 2.55 RF00177,RF01959,RF02542,RF01960 39039256 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<......>>....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((..)))))))).)))))......(((......((((((((..((...(((((((.(((((....(((((......))))).....)))))....((((..((((....))))..))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((.(((....))).)))....((......))....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with macrolone MCX-91, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.55A resolution; 16S Ribosomal RNA 8vtv 1v 13 2.55 39039256 10665 aaaaauguucuaa ............. ............. Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with macrolone MCX-91, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.55A resolution; MF-mRNA 8vtv 1w 74 2.55 RF00005 39039256 0030533 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcaccn <<<<<<<..<<<<......>>>><<<<<<<.....>>>>>>.>...<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[..)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with macrolone MCX-91, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.55A resolution; Aminoacylated Phe-tRNAphe 8vtv 1x 77 2.55 RF00005 URS000041AF00_562 39039256 0030533 0006412 562 cgcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaaccn .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with macrolone MCX-91, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.55A resolution; Aminoacylated fMet-tRNAmet 8vtv 1y 74 2.55 RF00005 39039256 0030533 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((......)))).((((.........)))).....(((((.......)))))))))))).... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with macrolone MCX-91, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.55A resolution; Deacylated tRNAphe 8vtv 2A 2800 2.55 RF02541 39039256 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<..<<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<....<<............>.>....>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<..>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((()))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...((((((((....((............).)....))))))))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((((((()))))))))).))..........]]].)....))))))))))...)))))))(((((((())))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(......[..(((((..(((.......(((((((....)))))))....)))..........].)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.((.))......(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with macrolone MCX-91, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.55A resolution; 23S Ribosomal RNA 8vtv 2B 120 2.55 RF00001 39039256 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> .(((((((.((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)).))))))). Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with macrolone MCX-91, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.55A resolution; 5S Ribosomal RNA 8vtv 2a 1503 2.55 RF00177,RF01959,RF02542,RF01960 39039256 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggau .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<......>>....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((.(....).)))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((((((....)))))))....(.(....).)....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.(.((....)).)).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with macrolone MCX-91, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.55A resolution; 16S Ribosomal RNA 8vtv 2v 13 2.55 39039256 10665 aaaaauguucuaa ............. ............. Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with macrolone MCX-91, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.55A resolution; MF-mRNA 8vtv 2w 72 2.55 RF00005 39039256 0030533 562 cccgganagcucagggagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcaccn <<<<<<..<<<<.....>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((...[.)))).((((.........)))).....(((((..]....)))))))))))..... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with macrolone MCX-91, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.55A resolution; Aminoacylated Phe-tRNAphe 8vtv 2x 77 2.55 RF00005 URS000041AF00_562 39039256 0030533 0006412 562 cgcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaaccn .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with macrolone MCX-91, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.55A resolution; Aminoacylated fMet-tRNAmet 8vtv 2y 73 2.55 RF00005 39039256 0030533 562 gcccgganagcucagggagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<.....>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....)))).((((.........)))).....(((((.......)))))))))))).... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with macrolone MCX-91, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.55A resolution; Deacylated tRNAphe 8vtw 1A 2872 2.35 RF02541 39039256 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<...<.<.......>.>...>>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((..(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...((((((((.(.((((((......)))).)))..))))))))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........(((((..(((......((((((((....))))))))...)))............)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..((((.))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with macrolone MCX-128 and protein Y at 2.35A resolution; 23S Ribosomal RNA 8vtw 1B 120 2.35 RF00001 39039256 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>. .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with macrolone MCX-128 and protein Y at 2.35A resolution; 5S Ribosomal RNA 8vtw 1a 1500 2.35 RF00177,RF01959,RF02542,RF01960 39039256 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<..........>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((())))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((((..(((((((....)))))))...((((....))))..))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with macrolone MCX-128 and protein Y at 2.35A resolution; 16S Ribosomal RNA 8vtw 2A 2867 2.35 RF02541 39039256 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..................>>>......................>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<..>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<.......<<<<<<......>>>>>>....>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((...))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((..))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((.(.((.(((......)))..)))..)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.........(((.((...((.........))....)).........(........)...))).....)))))))))).))..........]]].)....))))))))))...)))))))(((((((())))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........(((((..(((.......((((.((....)).))))....)))............)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))((((.))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with macrolone MCX-128 and protein Y at 2.35A resolution; 23S Ribosomal RNA 8vtw 2B 120 2.35 RF00001 39039256 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> (((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).))))))))))) Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with macrolone MCX-128 and protein Y at 2.35A resolution; 5S Ribosomal RNA 8vtw 2a 1504 2.35 RF00177,RF01959,RF02542,RF01960 39039256 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>.....<......>....>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((((((....)))))))....(((....)))....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with macrolone MCX-128 and protein Y at 2.35A resolution; 16S Ribosomal RNA 8vtx 1A 2871 2.4 RF02541 URS00001698E8_300852 39039256 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacganaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<.....<<<........>>>......>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<..<<<......(..>>...>>>.........<<......>>.).>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<.......<<<<.<......>.>>>>....>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<...>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((..(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((.(...((..........)..).)..)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((..((.........))...))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(......[..(((((..(((......((((((((....))))))))...)))..........].)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..(((...)))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the A2058-N6-dimethylated Thermus thermophilus 70S ribosome in complex with macrolone MCX-128, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.40A resolution; 23S Ribosomal RNA 8vtx 1B 120 2.4 RF00001 39039256 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> (((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).))))))))))) Crystal structure of the A2058-N6-dimethylated Thermus thermophilus 70S ribosome in complex with macrolone MCX-128, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.40A resolution; 5S Ribosomal RNA 8vtx 1a 1500 2.4 RF00177,RF01959,RF02542,RF01960 39039256 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<......>>....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((((((....))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((..((((....))))..))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((...(((((((....)))))))....(((....)))....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the A2058-N6-dimethylated Thermus thermophilus 70S ribosome in complex with macrolone MCX-128, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.40A resolution; 16S Ribosomal RNA 8vtx 1v 13 2.4 39039256 10665 aaaaauguucuaa ............. ............. Crystal structure of the A2058-N6-dimethylated Thermus thermophilus 70S ribosome in complex with macrolone MCX-128, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.40A resolution; MF-mRNA 8vtx 1w 74 2.4 RF00005 39039256 0030533 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcaccn <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[..)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of the A2058-N6-dimethylated Thermus thermophilus 70S ribosome in complex with macrolone MCX-128, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.40A resolution; Aminoacylated Phe-tRNAphe 8vtx 1x 77 2.4 RF00005 URS000041AF00_562 39039256 0030533 0006412 562 cgcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaaccn .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the A2058-N6-dimethylated Thermus thermophilus 70S ribosome in complex with macrolone MCX-128, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.40A resolution; Aminoacylated fMet-tRNAmet 8vtx 1y 74 2.4 RF00005 39039256 0030533 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[..)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of the A2058-N6-dimethylated Thermus thermophilus 70S ribosome in complex with macrolone MCX-128, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.40A resolution; Deacylated tRNAphe 8vtx 2A 2800 2.4 RF02541 URS00001698E8_300852 39039256 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacganaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<....<<............>.>....>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<..>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....)))).....(())....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((....((............).)....)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((((((()))))))))).))..........]]].)....))))))))))...)))))))(((((((())))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........(((((..((.......((((((((....))))))))....))............)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....))))))).((...)).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the A2058-N6-dimethylated Thermus thermophilus 70S ribosome in complex with macrolone MCX-128, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.40A resolution; 23S Ribosomal RNA 8vtx 2B 120 2.4 RF00001 39039256 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>>. ..(((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).))))))))).. Crystal structure of the A2058-N6-dimethylated Thermus thermophilus 70S ribosome in complex with macrolone MCX-128, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.40A resolution; 5S Ribosomal RNA 8vtx 2a 1503 2.4 RF00177,RF01959,RF02542,RF01960 39039256 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggau .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<......>>....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((((((....))))))).(..(.(....).)..).)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.(.((....)).)).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}... Crystal structure of the A2058-N6-dimethylated Thermus thermophilus 70S ribosome in complex with macrolone MCX-128, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.40A resolution; 16S Ribosomal RNA 8vtx 2v 13 2.4 39039256 10665 aaaaauguucuaa ............. ............. Crystal structure of the A2058-N6-dimethylated Thermus thermophilus 70S ribosome in complex with macrolone MCX-128, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.40A resolution; MF-mRNA 8vtx 2w 72 2.4 RF00005 39039256 0030533 562 cccgganagcucagggagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcaccn <<<<<<..<<<<.....>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>..... .(((((..((((...[.)))).((((.........)))).....(((((..]....))))))))))...... Crystal structure of the A2058-N6-dimethylated Thermus thermophilus 70S ribosome in complex with macrolone MCX-128, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.40A resolution; Aminoacylated Phe-tRNAphe 8vtx 2x 77 2.4 RF00005 URS000041AF00_562 39039256 0030533 0006412 562 cgcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaaccn .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the A2058-N6-dimethylated Thermus thermophilus 70S ribosome in complex with macrolone MCX-128, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.40A resolution; Aminoacylated fMet-tRNAmet 8vtx 2y 73 2.4 RF00005 39039256 0030533 562 gcccgganagcucagggagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<.....>>>>.<<<<<<<...>>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[.)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of the A2058-N6-dimethylated Thermus thermophilus 70S ribosome in complex with macrolone MCX-128, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.40A resolution; Deacylated tRNAphe 8vty 1A 2872 2.6 RF02541 39039256 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((..(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...((((((((.(.((((((......)))).)))..))))))))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(......[..(((((..(((......((((((((....))))))))...)))..........].)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..((((.))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with ciprofloxacin and protein Y at 2.60A resolution; 23S Ribosomal RNA 8vty 1B 120 2.6 RF00001 39039256 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with ciprofloxacin and protein Y at 2.60A resolution; 5S Ribosomal RNA 8vty 1a 1500 2.6 RF00177,RF01959,RF02542,RF01960 39039256 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<.<......>.>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((..)))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((.(.(((((....))))).).))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((...(((((((....)))))))...((((....))))...)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with ciprofloxacin and protein Y at 2.60A resolution; 16S Ribosomal RNA 8vty 2A 2867 2.6 RF02541 39039256 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<.......>>>....>>......................>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<.......<<<<<<......>>>>>>....>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((..))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...((((((((.(.((.(((......)))..)))..))))))))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((........((((.((....((.......)).....)).........(........)...))))....)))))))))).))..........]]].)....))))))))))...)))))))(((((((())))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((.(.((((.(......[..(((((..(((.......(((((((....)))))))....)))..........].)))))).)))).).)))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))((((.))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with ciprofloxacin and protein Y at 2.60A resolution; 23S Ribosomal RNA 8vty 2B 120 2.6 RF00001 39039256 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with ciprofloxacin and protein Y at 2.60A resolution; 5S Ribosomal RNA 8vty 2a 1504 2.6 RF00177,RF01959,RF02542,RF01960 39039256 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>.....<......>....>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((...(((((((....))))))).....((....)).....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with ciprofloxacin and protein Y at 2.60A resolution; 16S Ribosomal RNA 8vxx A 36 3.1 URS0000D77919_32630 32630 gcguacgaaggagaggagaggaagaggagaguacgc <<<<<<........................>>>>>> ((((((........................)))))) Mango II bound to 365A-061; Chains: A,B,C 8vxx B 36 3.1 URS0000D77919_32630 32630 gcguacgaaggagaggagaggaagaggagaguacgc <<<<<<........................>>>>>> ((((((........................)))))) Mango II bound to 365A-061; Chains: A,B,C 8vxx C 36 3.1 URS0000D77919_32630 32630 gcguacgaaggagaggagaggaagaggagaguacgc <<<<<<........................>>>>>> (((.((........................)).))) Mango II bound to 365A-061; Chains: A,B,C 8vxz A 36 3.0 URS0000D77919_32630 32630 gcguacgaaggagaggagaggaagaggagaguacgc <<<<<<........................>>>>>> ((((((........................)))))) Mango II bound to 365A-084; Chains: A,B,C 8vxz B 36 3.0 URS0000D77919_32630 32630 gcguacgaaggagaggagaggaagaggagaguacgc <<<<<<........................>>>>>> ((((((........................)))))) Mango II bound to 365A-084; Chains: A,B,C 8vxz C 36 3.0 URS0000D77919_32630 32630 gcguacgaaggagaggagaggaagaggagaguacgc <<<<<<........................>>>>>> ((((((........................)))))) Mango II bound to 365A-084; Chains: A,B,C 8vy0 A 36 3.1 URS0000D77919_32630 32630 gcguacgaaggagaggagaggaagaggagaguacgc <<<<<<........................>>>>>> ((((((........................)))))) Mango II bound to 365A-087; Chains: A,B,C 8vy0 B 36 3.1 URS0000D77919_32630 32630 gcguacgaaggagaggagaggaagaggagaguacgc <<<<<<........................>>>>>> ((((((........................)))))) Mango II bound to 365A-087; Chains: A,B,C 8vy0 C 36 3.1 URS0000D77919_32630 32630 gcguacgaaggagaggagaggaagaggagaguacgc <<<<<<........................>>>>>> ((((((........................)))))) Mango II bound to 365A-087; Chains: A,B,C 8vy1 A 36 3.1 URS0000D77919_32630 32630 gcguacgaaggagaggagaggaagaggagaguacgc <<<<<<........................>>>>>> ((((((........................)))))) Mango II bound to 365A-088; Chains: A,B,C 8vy1 B 36 3.1 URS0000D77919_32630 32630 gcguacgaaggagaggagaggaagaggagaguacgc <<<<<<........................>>>>>> ((((((........................)))))) Mango II bound to 365A-088; Chains: A,B,C 8vy1 C 36 3.1 URS0000D77919_32630 32630 gcguacgaaggagaggagaggaagaggagaguacgc <<<<<<........................>>>>>> ((((((........................)))))) Mango II bound to 365A-088; Chains: A,B,C 8w51 A 2904 2.4 RF02541 URS0000B21DEA_562 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaacccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccuu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<.........>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<..<<....>>...>>>>>..>....>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<..<<<.<<<<<.<<<<<<<<<<<.<<<............<<<<<..<<.......<<<<<<<<....>>>>>>>>....>>............>>>>>...>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>...>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>.. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((.(......).))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((..(((.....)))...))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((.((((....)))).))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((((((.((((.(..........((((..(((......((.(.(((....))).).))...)))............)))).).)))).)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(.(((((....))).)).)....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))).. Structure of YchF(H114A) on E.coli 50S ribosomal subunit; 23S rRNA 8w51 B 118 2.4 RF00001 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))). Structure of YchF(H114A) on E.coli 50S ribosomal subunit; 5S rRNA 8wce G 66 3.09 38661236 32630 ugcuucacguaggccuuggagccguacaugguuguaacaagccuaaguuugaaagguaaaaacaac ..............................<<<<<.....<<<<.........>>>>....>>>>> ..............................(((((.....((((.........))))....))))) Cryo-EM structure of a protein-RNA complex; RNA (66-MER) 8wce T 31 3.09 38661236 32630 gcauguacggcuccaaggccuacgugaagca ............................... ............................... Cryo-EM structure of a protein-RNA complex; RNA (31-MER) 8whx A 3020 2.8 RF02541 38245551 0003735 0005840 246196 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((((......((((((((((.....(((..(((((((((((((......((((((.[[.[[[.))).....((((((...(((]]]..]].)))......))))))...)))....(((....)))(((((((......))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))....((([...((((((((((.........[[[[[.....))))))))))....(.((((..(.....(((((((]]]]].))))))).(.(((.......(.((((.((((.(((...(.((((......)))))[[(...).(((.....]])))...)))...)))))))).)))).)......)...))))]....(((((((...[.......)))))))....).(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((..(((((((((..)))).)))))..)))).<.(.(........).).((((((....(((.((((((((((..(((...(((....)))...)))...((....))..((((.....))))....(((((((....)))))))....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......A))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([.((((((((.....(((....(((.((..(...(..(((....)))...)....).)).)))..)).).....))))))))....).]))))))).))..((((((((((......)))))).))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((.((((.....{.((..))...)))).))))).))...........]]].)....))))))))))...)))))))((((((((..))))))))....))))))(.((((((((((......((((((((....))).)))))...))))))))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]]((((((((((.(.....(((...(.((.(((......((((.(....).)))).....))).)).).....))).((...(((((...((((..(((..((((..(((((....{{....))))).((..(((....(((((((((((.((.....))))))))).....))))..[.)))...))...(((......))).....))))...)))...))))(..)....)))))..))..).)))))))))))))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((...((((....((((..)])))....))))..))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((....((((..((.(((...))).))...))))....))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....))[[..(((((.....>]])))))..((((((((.(((.((......((((((((((..(((((.(((.(((((.((.((((((((((....(.........(..((..(((......((.(((((....))))).))...)))............))..))....)))))))))).))...(((.((((((......)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.(.((((...((..))...)))).)...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..a.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..(((((...)))))....((((.((((.......)))).....(((.((((.(((....(((((....)))))...)))..))))..)))...))))....)))).. Cryo- EM structure of Mycobacterium smegmatis 70S ribosome and RafH.; 23S rRNA 8whx B 117 2.8 RF00001 38245551 0003735 0005840 246196 guuacggcgguccauagcggcagggaaacgcccggucccaucccgaacccggaagcuaagccugccagcgccgaugauacuacccauccggguggaaaaguaggacaccgccgaaca <<<.<<<<<<<.....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<.......<<<<<<....>>>>>>.......>>..>>>>>>>>>>. (((.(((((((.....((((((((.....((((((...(.....)...))))..))....)))))).)).((.......((((((....)))))).......))..)))))))))). Cryo- EM structure of Mycobacterium smegmatis 70S ribosome and RafH.; 5S rRNA 8whx a 1515 2.8 RF01959,RF00177,RF02542,RF01960 38245551 0003735 0005840 246196 uggagaguuugauccuggcucaggacgaacgcuggcggcgugcuuaacacaugcaagucgaacggaaaggcccuuucggggguacucgaguggcgaacgggugaguaacacgugggugaucugcccugcacuuugggauaagccugggaaacugggucuaauaccgaauacacccugcuggucgcauggccugguaggggaaagcuuuugcggugugggaugggcccgcggccuaucagcuuguugguggggugauggccuaccaaggcgacgacggguagccggccugagagggugaccggccacacugggacugagauacggcccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagcgacgccgcgugagggaugacggccuucggguuguaaaccucuuucagcacagacgaagcgcaagugacgguaugugcagaagaaggaccggccaacuacgugccagcagccgcgguaauacguaggguccgagcguuguccggaauuacugggcguaaagagcucguaggugguuugucgcguuguucgugaaaacucacagcuuaacugugggcgugcgggcgauacgggcagacuagaguacugcaggggagacuggaauuccugguguagcgguggaaugcgcagauaucaggaggaacaccgguggcgaaggcgggucucugggcaguaacugacgcugaggagcgaaagcguggggagcgaacaggauuagauacccugguaguccacgccguaaacgguggguacuagguguggguuuccuuccuugggauccgugccguagcuaacgcauuaaguaccccgccuggggaguacggccgcaaggcuaaaacucaaaggaauugacgggggcccgcacaagcggcggagcauguggauuaauucgaugcaacgcgaagaaccuuaccuggguuugacaugcacaggacgccggcagagaugucgguucccuuguggccugugugcagguggugcauggcugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuugucucauguugccagcacguuaugguggggacucgugagagacugccggggucaacucggaggaagguggggaugacgucaagucaucaugccccuuauguccagggcuucacacaugcuacaauggccgguacaaagggcugcgaugccgugagguggagcgaauccuuucaaagccggucucaguucggaucggggucugcaacucgaccccgugaagucggagucgcuaguaaucgcagaucagcaacgcugcggugaauacguucccgggccuuguacacaccgcccgucacgucaugaaagucgguaacacccgaagccgguggccuaacccuuguggagggagccgucgaaggugggaucggcgauugggacgaagucguaacaagguagccguaccggaaggugcggcuggaucaccucc ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<..<<<<<<<....>>>>>.>>>..>>>>>......<<........<<<<<<<..<<...<<<<<<<<<<<<.....<<<<<<....>>>>>>......>>>>.....<<<<<<<<<<<<..>>>>>.>>>>>>>....<<....>>>>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<<....>>.......>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<.....<<<<<<<.....>>>>>>>...>>>>>>>..>>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<<..<<<......>>>.....>>>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<.......>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>.<<.....>>.>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<<..<<<......>>>>>.....>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>......>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<..<<<<....<.<<<<..<<<..<<.....>>.>>>.>>>>.>...>>>>..>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>........... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((......)))).)))..)))))......(((.......(((((((..((...((((((((((((.....((((((....))))))......)))).....(((((((((((....)))).)))))))....((....))))))))))..))))))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(..((....))..)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((.....(((((((.....)))))))...))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((.(.......).))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((((..(((((((....))))))).((.....))))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((.(...((..(((......)))))....).)))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....)))......)))))))......(....(((((((........)))))))....)..)..))))).....(((((((..........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((..((((....(.((((..(((..(((..).)).))).)))).)...))))..))))))..))).))))..).))...)..)..(((((((((....)))))))))}.......... Cryo- EM structure of Mycobacterium smegmatis 70S ribosome and RafH.; 16S rRNA 8why A 3017 2.7 RF02541 38245551 0003735 0005840 246196 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Cryo- EM structure of Mycobacterium smegmatis 50S ribosomal subunit (body 1) of 70S ribosome and RafH.; 23S rRNA 8why B 117 2.7 RF00001 38245551 0003735 0005840 246196 guuacggcgguccauagcggcagggaaacgcccggucccaucccgaacccggaagcuaagccugccagcgccgaugauacuacccauccggguggaaaaguaggacaccgccgaaca <<<.<<<<<<<.....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<.......<<<<<<....>>>>>>.......>>..>>>>>>>>>>. (((.(((((((.....((((((((.....((((((...(.....)...))))..))....)))))).)).((.......((((((....)))))).......))..)))))))))). Cryo- EM structure of Mycobacterium smegmatis 50S ribosomal subunit (body 1) of 70S ribosome and RafH.; 5S rRNA 8wi7 A 3025 3.5 RF02541 38245551 0003735 0005840 246196 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Cryo- EM structure of Mycobacterium smegmatis 70S ribosome, bS1 and RafH.; 23S rRNA 8wi7 B 118 3.5 RF00001 38245551 0003735 0005840 246196 guuacggcgguccauagcggcagggaaacgcccggucccaucccgaacccggaagcuaagccugccagcgccgaugauacuacccauccggguggaaaaguaggacaccgccgaacac <<<.<<<<<<<.....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<.......<<<<<<....>>>>>>.......>>..>>>>>>>>>>.. (((.(((((((.....((((((((.....((((((...(.....)...))))..))....)))))).)).((.......((((((....)))))).......))..)))))))))).. Cryo- EM structure of Mycobacterium smegmatis 70S ribosome, bS1 and RafH.; 5S rRNA 8wi7 a 1515 3.5 RF01959,RF00177,RF02542,RF01960 38245551 0003735 0005840 246196 uggagaguuugauccuggcucaggacgaacgcuggcggcgugcuuaacacaugcaagucgaacggaaaggcccuuucggggguacucgaguggcgaacgggugaguaacacgugggugaucugcccugcacuuugggauaagccugggaaacugggucuaauaccgaauacacccugcuggucgcauggccugguaggggaaagcuuuugcggugugggaugggcccgcggccuaucagcuuguugguggggugauggccuaccaaggcgacgacggguagccggccugagagggugaccggccacacugggacugagauacggcccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagcgacgccgcgugagggaugacggccuucggguuguaaaccucuuucagcacagacgaagcgcaagugacgguaugugcagaagaaggaccggccaacuacgugccagcagccgcgguaauacguaggguccgagcguuguccggaauuacugggcguaaagagcucguaggugguuugucgcguuguucgugaaaacucacagcuuaacugugggcgugcgggcgauacgggcagacuagaguacugcaggggagacuggaauuccugguguagcgguggaaugcgcagauaucaggaggaacaccgguggcgaaggcgggucucugggcaguaacugacgcugaggagcgaaagcguggggagcgaacaggauuagauacccugguaguccacgccguaaacgguggguacuagguguggguuuccuuccuugggauccgugccguagcuaacgcauuaaguaccccgccuggggaguacggccgcaaggcuaaaacucaaaggaauugacgggggcccgcacaagcggcggagcauguggauuaauucgaugcaacgcgaagaaccuuaccuggguuugacaugcacaggacgccggcagagaugucgguucccuuguggccugugugcagguggugcauggcugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuugucucauguugccagcacguuaugguggggacucgugagagacugccggggucaacucggaggaagguggggaugacgucaagucaucaugccccuuauguccagggcuucacacaugcuacaauggccgguacaaagggcugcgaugccgugagguggagcgaauccuuucaaagccggucucaguucggaucggggucugcaacucgaccccgugaagucggagucgcuaguaaucgcagaucagcaacgcugcggugaauacguucccgggccuuguacacaccgcccgucacgucaugaaagucgguaacacccgaagccgguggccuaacccuuguggagggagccgucgaaggugggaucggcgauugggacgaagucguaacaagguagccguaccggaaggugcggcuggaucaccucc ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<..<<<<<<<....>>>>>.>>>..>>>>>......<<........<<<<<<<..<<...<<<<<<<<<<<<.....<<<<<<....>>>>>>......>>>>.....<<<<<<<<<<<<..>>>>>.>>>>>>>....<<....>>>>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<<....>>.......>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<.....<<<<<<<.....>>>>>>>...>>>>>>>..>>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<<..<<<......>>>.....>>>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<.......>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>.<<.....>>.>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<<..<<<......>>>>>.....>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>......>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<..<<<<....<.<<<<..<<<..<<.....>>.>>>.>>>>.>...>>>>..>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>........... ....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((......)))).)))..)))))......(((.......(((((((..((...((((((((((((.....((((((....))))))......)))).....(((((((((((....)))).)))))))....((....))))))))))..))))))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(..((....))..)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((.....(((((((.....)))))))...))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((.(.......).))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...((((((((..(((((((....))))))).(((..).))))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((.(...((..(((......)))))....).)))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....))))))))..)).)))))))).(...(((((((.....(((..((...(((....)))...))....)))......)))))))......(....(((((((........)))))))....)..)..))))).....(((((((..........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((..((((....(.((((..(((..(((..).)).))).)))).)...))))..))))))..))).))))..).))...)..)..(((((((((....)))))))))}.......... Cryo- EM structure of Mycobacterium smegmatis 70S ribosome, bS1 and RafH.; 16S rRNA 8wi8 A 3025 2.7 RF02541 38245551 0003735 0005840 246196 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Cryo- EM structure of Mycobacterium smegmatis 50S ribosomal subunit (body 1) of 70S ribosome, bS1 and RafH.; 23S rRNA 8wi8 B 118 2.7 RF00001 38245551 0003735 0005840 246196 guuacggcgguccauagcggcagggaaacgcccggucccaucccgaacccggaagcuaagccugccagcgccgaugauacuacccauccggguggaaaaguaggacaccgccgaacac <<<.<<<<<<<.....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<.......<<<<<<....>>>>>>.......>>..>>>>>>>>>>.. (((.(((((((.....((((((((.....((((((...(.....)...))))..))....)))))).)).((.......((((((....)))))).......))..)))))))))).. Cryo- EM structure of Mycobacterium smegmatis 50S ribosomal subunit (body 1) of 70S ribosome, bS1 and RafH.; 5S rRNA 8wib A 3022 3.5 RF02541 38245551 0003735 0005840 246196 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Cryo- EM structure of Mycobacterium smegmatis 70S ribosome, E- tRNA and RafH.; 23S rRNA 8wib B 117 3.5 RF00001 38245551 0003735 0005840 246196 guuacggcgguccauagcggcagggaaacgcccggucccaucccgaacccggaagcuaagccugccagcgccgaugauacuacccauccggguggaaaaguaggacaccgccgaaca <<<.<<<<<<<.....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<.......<<<<<<....>>>>>>.......>>..>>>>>>>>>>. (((.(((((((.....((((((((.....((((((...(.....)...))))..))....)))))).)).((.......((((((....)))))).......))..)))))))))). Cryo- EM structure of Mycobacterium smegmatis 70S ribosome, E- tRNA and RafH.; 5S rRNA 8wib C 76 3.5 RF00005 38245551 0030533 246196 cgcgggguggagcagccgguagcucgucuggcucauaaccagaagaucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.....[..)))).(((((.......))))).....(.(((..]....))).)))))))..... Cryo- EM structure of Mycobacterium smegmatis 70S ribosome, E- tRNA and RafH.; E-tRNA 8wib a 1515 3.5 RF01959,RF00177,RF02542,RF01960 38245551 0003735 0005840 246196 uuggagaguuugauccuggcucaggacgaacgcuggcggcgugcuuaacacaugcaagucgaacggaaaggcccuuucggggguacucgaguggcgaacgggugaguaacacgugggugaucugcccugcacuuugggauaagccugggaaacugggucuaauaccgaauacacccugcuggucgcauggccugguaggggaaagcuuuugcggugugggaugggcccgcggccuaucagcuuguugguggggugauggccuaccaaggcgacgacggguagccggccugagagggugaccggccacacugggacugagauacggcccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagcgacgccgcgugagggaugacggccuucggguuguaaaccucuuucagcacagacgaagcgcaagugacgguaugugcagaagaaggaccggccaacuacgugccagcagccgcgguaauacguaggguccgagcguuguccggaauuacugggcguaaagagcucguaggugguuugucgcguuguucgugaaaacucacagcuuaacugugggcgugcgggcgauacgggcagacuagaguacugcaggggagacuggaauuccugguguagcgguggaaugcgcagauaucaggaggaacaccgguggcgaaggcgggucucugggcaguaacugacgcugaggagcgaaagcguggggagcgaacaggauuagauacccugguaguccacgccguaaacgguggguacuagguguggguuuccuuccuugggauccgugccguagcuaacgcauuaaguaccccgccuggggaguacggccgcaaggcuaaaacucaaaggaauugacgggggcccgcacaagcggcggagcauguggauuaauucgaugcaacgcgaagaaccuuaccuggguuugacaugcacaggacgccggcagagaugucgguucccuuguggccugugugcagguggugcauggcugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuugucucauguugccagcacguuaugguggggacucgugagagacugccggggucaacucggaggaagguggggaugacgucaagucaucaugccccuuauguccagggcuucacacaugcuacaauggccgguacaaagggcugcgaugccgugagguggagcgaauccuuucaaagccggucucaguucggaucggggucugcaacucgaccccgugaagucggagucgcuaguaaucgcagaucagcaacgcugcggugaauacguucccgggccuuguacacaccgcccgucacgucaugaaagucgguaacacccgaagccgguggccuaacccuuguggagggagccgucgaaggugggaucggcgauugggacgaagucguaacaagguagccguaccggaaggugcggcuggaucaccuc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<..<<<<<<<....>>>>>.>>>..>>>>>......<<........<<<<<<<..<<...<<<<<<<<<<<<.....<<<<<<....>>>>>>......>>>>.....<<<<<<<<<<<<..>>>>>.>>>>>>>....<<....>>>>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<<....>>.......>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<.....<<<<<<<.....>>>>>>>...>>>>>>>..>>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<<..<<<......>>>.....>>>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<.......>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>.<<.....>>.>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<....<<..<<<......>>>>>.....>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>......>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<..<<<<....<.<<<<..<<<..<<.....>>.>>>.>>>>.>...>>>>..>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.......... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((......)))).)))..)))))......(((.......(((((((..((...((((((((((((.....((((((....))))))......)))).....(((((((((((....)))).)))))))....((....))))))))))..))))))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(..((....))..)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((.....(((((((.....)))))))...))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((.(.......).))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((((..(((((((....))))))).((.....))))))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((.(...((..(((......)))))....).)))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....)))......)))))))......(....(((((((........)))))))....)..)..))))).....(((((((..........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((..((((....(.((((..(((..(((..).)).))).)))).)...))))..))))))..))).))))..).))...)..)..(((((((((....)))))))))}......... Cryo- EM structure of Mycobacterium smegmatis 70S ribosome, E- tRNA and RafH.; 16S rRNA 8wic A 3022 3.5 RF02541 38245551 0003735 0005840 246196 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<<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<<......<<<<<<.[[.(((.>>>.....<<<<<<<..<<<)))..]].>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<.....>>..<<<<<<.....<<.....>>....>>>>>>...<<<....<<<<<<<<<<.........(((((.....>>>>>>>>>>......<<<<<.<.....<<<<<<<))))).>>>>>>><<<<<<.......<<<<<<.<<<<.<<<.....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>>>.....>.>.>>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..>>>......>>.>>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<<<<..>>>>.>>>>>..>>>>...<.<........>.>.<<<<<<....<<<.<<<<<<<<<<..<<<...<<<....>>>...>>>...<<....>>..<<<<.....>>>>....<<<<<<<....>>>>>>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<....<<<<<<<<.....<<<....<<<.<.<<......<<<<....>>>>.......>>.>.>>>..>>.>.....>>>>>>>>.......>>>>>>>.>>..<<<<<<<<<<......>>>>>>.>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<......>....>>>>>>>>>.>>...........)))......>>>>>>.>>>...>>>>>>><<<<<<<<..>>>>>>>>....>>>>>><.<<<<<<<<<<......<<<<<<<<....>>>.>>>>>...>>>>>>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<.......<<<<...<<<<<<<......<<<<......>>>>.....>>>>>>>.....>>>>.<<...<<<<<...<<<<..<<<..<<<<..<<<<<...((((...>>>>>.<<..<<<<...<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>...>>>>...>>...<<<......>>>.....>>>>...>>>...>>>>........>>>>>..>>....>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<<...<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<...<<<<....<<<.....>>>....>>>>..>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<..<<....<<<<..<<<<<<...>>>>>>...>>>>....>>..>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>>>>>>>>.....>.((..<<<<<......))>>>>>..<<<<<<<<.<<<.<<......<<<<<<<<<<..<<<<<.<<<.<<<<<.<<.<<<<<<<<<<<...............<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>......>>>>>>>>>>>.>>...<<<.<<<<<<......>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.<<..>>>>..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<.<<<<...<<....>>...>>>>.>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))))>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<...>>>>>....<<<<.<<<<.......>>>>.....<<<.<<<<.<<<....<<<<<....>>>>>...>>>..>>>>..>>>...>>>>....>>>>.. ((((......((((((((((.....(((..(((((((((((((......((((((.[[.[[[.))).....((((((...(((]]]..]].)))......))))))...)))....(((....)))(((((((......))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))....((([...((((((((((.........[[[[[.....))))))))))....(.((((..(.....((((((.]]]]]..)))))).(((((.......((((((.((((.(((...(.((((......)))))[[(...).(((.....]])))...)))...)))))))))))))))......)...))))]....(((((((...[.......)))))))....).(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((..(((((((((..)))).)))))..)))).<.(.(........).).((((((....(((.((((((((((..(((...(((....)))...)))...((....))..((((.....))))....(((((((....)))))))....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......A))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([.((((((((.....(((....(((.((..(...(..(((....)))...)....).)).)))..)).).....))))))))....).]))))))).))..((((((((((......)))))).))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((.((((.....{.((....))...)))).))))).))...........]]].)....))))))))))...)))))))((((((((..))))))))....))))))(.((((((((((......((((((((....))).)))))...))))))))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]]((((((((((.(.....(((...(.((.((.......((((......))))......)).)).).....))).((...(((((...((((..(((..((((..(((((....{{....))))).((..(((....(((((((((((.((.....))))))))).....))))..[.)))...))...(((......))).....))))...)))...))))(..)....)))))..))..).)))))))))))))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((...((((....((((..)])))....))))..))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((....((((..((.(((...))).))...))))....))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....))[[..(((((.....>]])))))..((((((((.(((.((......((((((((((..(((((.(((.(((((.((.((((((((((.(..(............((...((......((.(((((....))))).))...)).............))...)..).)))))))))).))...(((.((((((......)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.(.((((...((....))...)))).)...).)).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..a.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..(((((...)))))....((((.((((.......)))).....(((.((((.(((....(((((....)))))...)))..))))..)))...))))....)))).. Cryo- EM structure of Mycobacterium smegmatis 50S ribosomal subunit (body 1) of 70S ribosome, E- tRNA and RafH.; 23S rRNA 8wic B 117 3.5 RF00001 38245551 0003735 0005840 246196 guuacggcgguccauagcggcagggaaacgcccggucccaucccgaacccggaagcuaagccugccagcgccgaugauacuacccauccggguggaaaaguaggacaccgccgaaca <<<.<<<<<<<.....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<.......<<<<<<....>>>>>>.......>>..>>>>>>>>>>. (((.(((((((.....((((((((.....((((((...(.....)...))))..))....)))))).)).((.......((((((....)))))).......))..)))))))))). Cryo- EM structure of Mycobacterium smegmatis 50S ribosomal subunit (body 1) of 70S ribosome, E- tRNA and RafH.; 5S rRNA 8wic C 76 3.5 RF00005 38245551 0030533 246196 cgcgggguggagcagccgguagcucgucuggcucauaaccagaagaucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.....[..)))).(((((.......))))).....(.(((..]....))).)))))))..... Cryo- EM structure of Mycobacterium smegmatis 50S ribosomal subunit (body 1) of 70S ribosome, E- tRNA and RafH.; E-tRNA 8wkp A16S 1325 4.62 RF01959,RF00177,RF01960,RF02542 38599770 0003735 0005840 330779 auuccgguugauccugccggacccgaccgcuaucgggguagggauaagccaugggagucuuacacucccggguaagggaguguggcggacggcugaguaacacguggcuaaccuacccucgggacggggauaaccccgggaaacuggggauaauccccgauagggaaggaguccuggaaugguuccuucccuaaagggcuauaggcuauuucccguuuguagcgcccgaggauggggcuacggcccaucaggcugucggugggguaaaggcccaccgaaccuauaacggguaggggccguggaagcgggagccuccaguugggcacugagacaagggcccaggcccuacggggcgcaccaggcgcgaaacguccccaaugcgcgaaagcgugagggcgcuaccccgagugccuccgcaggaggcuuuuccccgcucuaaaaaggcgggggaauaagcggggggcaagucuggugucagccgccgcgguaauaccagcuccgcgaguggucggggugauuacugggccuaaagcgccuguagccggcccaccaagucgccccuuaaaguccccggcucaaccggggaacugggggcgauacuggugggcuagggggcgggagaggcgggggguacucccggaguaggggcgaaauccuuagauaccgggaggaccaccaguggcggaagcgccccgcuagaacgcgcccgacggugagaggcgaaagccgggggucccggcuguaaacgaugcgggcuaggugucgaguaggcuuagagccuacucggugccgcagggaagccguuaagcccgccgccuggggaguacggucgcaagacugaaacuuaaaggaauuggcgggggagcaccacaagggguggaaccugcggcucaauuggagucaacgccuggaaucuuaccggggagaccgcaguaugacggccaggcuaacgaccuugccugacucgcggagaggaggugcauggccgucgccagcucguguugugaaauguccgguuaaguccggcaacgagcgagacccccaccccuaguugguauucuggacuccgguccagaaccacacuagggggacugccggcguaagccggaggaaggagggggccacggcaggucagcaugccccgaaaccgggccgcacgcggguuacaauggcagggacaacgggaugcuaccucgaaagggggagccaauccuuaaacccugccgcaguugggaucgagggcugaaacccgcccucgugaacgaggaaucccuaguaaccgcgggucaacaacccgcggugaauacgucccugcuccuugcaca ...<<<<<.[.((((>>>>>.<<<<<<<<......<<<.<<......<<<.<<<...<...<<<<<<<<......>>>>>>>>.>......<<<........<<<<<<<..<<...<<<<<<<.<<<<.....<<<<........>>>>......>>>>...<<<<<<.<<.<<......>>>>.>>>>>>........<<<................>>>...>>>>>>>..>>>>>>>>>.<<<....<<....<<<<<<<.......>>>>>>>..>>......>>>..<<<<<<<<....>>>>...>>>>.>>><<<<<............>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>..>>>....<<<<<.....>>>>>...<<<<<<<.........>>>>>>>.....<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>...>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<......<<<<<<<.....>>>>>>>....>>>>>>>..>>>>>>>>>...<<<<<<.....<<<<<<<<<<.<<<<<<<....<<........>>.......>>>>>>>.>>>.......<<....>>.>>>>>>>....>>>.>>>...>>>...>>>>...<<<<<<.....>>>>>>.........<<<<<<..<<<.<<<<<<.<<<.....>>>.>>>>>>.>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).].<.....<<<<<...<<.<<<<<..<<.<<<<<<<.......<<........>>..........<<<...................<<.<<<.......>>>.>>..............<<.<<....<<<<<.......<<<<<<............<<<<......>>>>..>>>>>>....<<<...<<<<<<<..........<<<<....>>>>.........>>>>>>>.....<<<<<....>>>>>.........>>>.........>>>...>>..>>>>.....>>>....>.>>>>>>>>.....<<<.<<<.......<..<...<<<<....>>>>...>....>......>>>.>>>...........<<<<<<<........>>>>>>>...........>>>>>....<<<<<<<<.......>>>>>>>>......>>....>>>>>...>... ...((((....[[[..)))).(((((((.(.....(((..((.....(((.(((..(.(..((((((((......))))))))).)......(((.......(((((((..((...(((((((..((((....((.(((....)).))).....))))....((((((.(..((......)).).))))))....(..(((.(..............).)))).)))))))..))))))))).(((....((...((((((((.......)))))))).))......)))..(.(((((......)))...)).)))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)...)))....((((((...)))))).(..((((((.........))))))..)...((((.[[......((((.....((..]])).......))))..))))..).)))))))..........((([[...(.((((...(((.(((((((.(((((((((......(((((((.....)))))))....)))))))..)))))))))..(((((((.....(((((((((..(((((((....((........)).......)))))))..)).......((....)).)))))))....))).)))..))))...))))....((((((...))))))..........((((((..((..((((((.(((.....).))))))))..))...((..]])).....))))))))))...(.......(((....))).....).....]]]...(.....(((((...((..(((((..(.((.(((((......((........))..........(((......((..((.......((.(((.(....))).)))....))...))...((.((....((((((.(....((((((.(......)....(((......)))...))))))....(((((.(((((((.........(((((....)))))........)))))))..(..(((((....))))).....)..)))))....).).)))...))..)))).....)))...)).))).)).).(...(((.(((...(..((..((..((.(....).))..))....)).)...))).)))......(....(((((((........)))))))....)..)..))))).....((((((((.......))))))))......))....)))))...)... Structural basis of translation inhibition by a valine tRNA-derived fragment; RNA (1328-MER) 8wkp VTRF 25 4.62 38599770 330779 gguugguggucuagucugguuauga ......................... .........(..............) Structural basis of translation inhibition by a valine tRNA-derived fragment; RNA (25-MER) 8wq2 A16S 1328 4.1 RF01959,RF00177,RF01960,RF02542 38599770 0003735 0005840 330779 auuccgguugauccugccggacccgaccgcuaucgggguagggauaagccaugggagucuuacacucccggguaagggaguguggcggacggcugaguaacacguggcuaaccuacccucgggacggggauaaccccgggaaacuggggauaauccccgauagggaaggaguccuggaaugguuccuucccuaaagggcuauaggcuauuucccguuuguagccgcccgaggauggggcuacggcccaucaggcugucggugggguaaaggcccaccgaaccuauaacggguaggggccguggaagcgggagccuccaguugggcacugagacaagggcccaggcccuacggggcgcaccaggcgcgaaacguccccaaugcgcgaaagcgugagggcgcuaccccgagugccuccgcaggaggcuuuuccccgcucuaaaaaggcgggggaauaagcggggggcaagucuggugucagccgccgcgguaauaccagcuccgcgaguggucggggugauuacugggccuaaagcgccuguagccggcccaccaagucgccccuuaaaguccccggcucaaccggggaacugggggcgauacuggugggcuagggggcgggagaggcgggggguacucccggaguaggggcgaaauccuuagauaccgggaggaccaccaguggcggaagcgccccgcuagaacgcgcccgacggugagaggcgaaagccgggggucccggcuguaaacgaugcgggcuaggugucgaguaggcuuagagccuacucggugccgcagggaagccguuaagcccgccgccuggggaguacggucgcaagacugaaacuuaaaggaauuggcgggggagcaccacaagggguggaaccugcggcucaauuggagucaacgccuggaaucuuaccgggggagaccgcaguaugacggccaggcuaacgaccuugccugacucgcggagaggaggugcauggccgucgccagcucguguugugaaauguccgguuaaguccggcaacgagcgagacccccaccccuaguugguauucuggacuccgguccagaaccacacuagggggacugccggcguaagccggaggaaggagggggccacggcaggucagcaugccccgaaacccgggccgcacgcggguuacaauggcagggacaacgggaugcuaccucgaaagggggagccaauccuuaaacccugccgcaguugggaucgagggcugaaacccgcccucgugaacgaggaaucccuaguaaccgcgggucaacaacccgcggugaauacgucccugcuccuugcaca ...<<<<..[..(((.>>>>.<<<<<<<.......<<<.<<......<<<.<<<..<<<..<<<<<<<<......>>>>>>>>>>>......<<..<.....<<<<<<<..<<...<<<<<<..<<<<<....<<<<........>>>>.....>>>>>...<<<<<<<...<<......>>..>>>>>>>.....<<<<<<................>>>>>>..>>>>>>..>>>>>>>>>.<<<....<<...<<<<<<<.........>>>>>>>.>>......>>>..<<<<<<<<....>>>>...>>>>>>>.<<<<<............>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>..>>>....<<<<<.....>>>>>...<<<<<<<.........>>>>>>>.....<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>....>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<..<<<<<......<<<<<<<.....>>>>>>>....>>>>>....>>>>>>>>>...<<<<<<.....<<<<<<<<<<.<<<<<<.....<<........>>........>>>>>>.>>>.......<<....>>.>>>>>>>....>>>.>>>...>>>...>>>>....<<<<<<...>>>>>>..........<<<<<<..<<<.<<<<<<<<<<.....>>>>>>>>>>.>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))..]....<..<<<<<<...<.<<<<<...<<<<<<<<<<......<<........>>..........<<<<......<<..........<.<.<<<.......>>>.>.>........>>...<<.<<...<<<<<<<<.....<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>....<<<<<.<<<<<<...<....<..<<<<....>>>>.>.....>..>>>>>>.....<<<<<....>>>>>........>>>>>.....>>.>>>...>>>.>>>>.....>>>>...>>.>>>>>>>>.....<<<<<<<......<<..<<..<<<......>>>..>>....>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>......>>>>>....<<<<<<<<.......>>>>>>>>......>....>>>>>>.>..... ...((((.....[[..)))).((((.((.(.....(((.(((.....(((.(((..(.(..((((((((......))))))))).)......(((.......((((((...((...(((((((.(((((....((((.(....).)))).....)))))...((((((((..((......)).))))))))....(.((((((..(........)..))))))).)))))))..)).)))))).(((....((...((((((((.......)))))))).))......)))..(.((((((....))))...)).)))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).))..)))....((((((...))))))...(((((((.........)))))).)....((((.[[......((((.....((..]])).......))))..))))..).)).))))..........((([[...(.((((...(((.(((((((.((.((((((......(((((((.....)))))))....))))))...)))))))))..(((((((.....(((((((((..(((((((....((........)).......)))))))..)).......((....)).)))))))....))).)))..))))...))))....((((((...))))))..........((((((..((..((((((((((.....))))))))))..))...((..]])).....)))))))))).(.(.......(((....))).....).)...]]....(.....((((((...(.((((((..((((((((((......((........))........(.(((.......((..((.......((..((.(....)))..))....))...))...((.((....((((((((....((((((((......))..((((......))))..))))))....(((((.(((((((.(......(.((((....)))).)......))))))))..(..(((((....))))).....)..)))))....))).)))...))..))))......))))..)).)))))))).(...(((((((......((..((..((.(....).))..))....)).....)))))))......(....(((((((........)))))))....)..)..))))))....((((((((.......))))))))......)....))))))...)... Structural basis of translation inhibition by a valine tRNA-derived fragment; RNA (1328-MER) 8wq2 VTRF 26 4.1 38599770 2246 ggguugguggucuagucugguuauga ..........<..............> ..........((............)) Structural basis of translation inhibition by a valine tRNA-derived fragment; RNA (26-MER) 8wq4 A16S 1325 4.53 RF01959,RF00177,RF01960,RF02542 38599770 0003735 0005840 330779 auuccgguugauccugccggacccgaccgcuaucgggguagggauaagccaugggagucuuacacucccggguaagggaguguggcggacggcugaguaacacguggcuaaccuacccucgggacggggauaaccccgggaaacuggggauaauccccgauagggaaggaguccuggaaugguuccuucccuaaagggcuauagguauuucccguuuguagccgcccgaggauggggcuacggcccaucaggcugucggugggguaaaggcccaccgaaccuauaacggguaggggccguggaagcgggagccuccaguugggcacugagacaagggcccaggcccuacggggcgcaccaggcgcgaaacguccccaaugcgcgaaagcgugagggcgcuaccccgagugccuccgcaggaggcuuuuccccgcucuaaaaaggcgggggaauaagcggggggcaagucuggugucagccgccgcgguaauaccagcuccgcgaguggucggggugauuacugggccuaaagcgccuguagccggcccaccaagucgccccuuaaaguccccggcucaaccggggaacugggggcgauacuggugggcuagggggcgggagaggcgggggguacucccggaguaggggcgaaauccuuagauaccgggaggaccaccaguggcggaagcgccccgcuagaacgcgcccgacggugagaggcgaaagccgggggucccggcuguaaacgaugcgggcuaggugucgaguaggcuuagagccuacucggugccgcagggaagccguuaagcccgccgccuggggaguacggucgcaagacugaaacuuaaaggaauuggcgggggagcaccacaagggguggaaccugcggcucaauuggagucaacgccuggaaucuuaccggggagaccgcaguaugacggccaggcuaacgaccuugccugacucgcggagaggaggugcauggccgucgccagcucguguugugaaauguccgguuaaguccggcaacgagcgagacccccaccccuaguugguauucuggacuccgguccagaaccacacuagggggacugccggcguaagccggaggaaggagggggccacggcaggucagcaugccccgaaaccgggccgcacgcggguuacaauggcagggacaacgggaugcuaccucgaaagggggagccaauccuuaaacccugccgcaguugggaucgagggcugaaacccgcccucgugaacgaggaaucccuaguaaccgcgggucaacaacccgcggugaauacgucccugcuccuugcaca ...<<<<<...((((>>>>>.<<<<<<<<......<<<.<<......<<<.<<<...<...<.<<<<<........>>>>>.>.>.......<<..<.....<<<<<<<..<<...<<<<<<<.<<<<<....<<<<........>>>>.....>>>>>....<<.<<<.<<<.......>>>>>.>>.>......<<<<<<.<...........>.>>>>>>.>>>>>>>..>>>>>>>>>.<<<....<<....<<<<<<<.......>>>>>>>..>>......>>>....<<<<<<....>>>>...>>..>>>.<<<<<............>>>>>.<<<<<..>>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>..>>>....<<<<<.....>>>>>...<<<<<<<.........>>>>>>>.....<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>...>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<..<<<<<......<<<<<<<.....>>>>>>>....>>>>>....>>>>>>>>>...<<<<<<.....<<<<<<<<<..<<<<<<<....<<........>>.......>>>>>>>..>>.......<<....>>.>>>>>>>....>>>.>>>...>>>...>>>>....<<<<<.....>>>>>..........<<<<<<..<<<.<<<<<<<<<<.....>>>>>>>>>>.>>>...<<..))>>.....>>>>>>.>>>..<<.....<<<<<....>>>>>...>>...))))..........<<<<<..<<.<<<<<...<<<<<<<.<<......<..........>..........<<<..........<........<<.<<<.......>>>.>>.....>........<<.<<....<<<<<<<.....<<<<<.<<......>>..<<<<......>>>>...>>>>>....<<<<<.<<<<.<<.........<<<<<....>>>>>........>>.>>>>.....<<<<<....>>>>>........>>>>>.....>>.>>>...>>..>>>>.....>>>...>>..>>>>>>>.....<<<<<<<......<<..<<..<<<......>>>..>>....>>.....>>>>>>>.............<<<<<........>>>>>.............>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>........ ...((((....[[[..)))).(((((((.(.....(((.(((.....(((.(((..(((..(.(((((........))))).))))......(((.......(((((((..((...(((((((.(((((....((.(.(....)..))).....)))))...((((((.(..((......)).).))))))....(.((((((.............))))))).)))))))..))))))))).(((....((....(((((((.......)))))))..))......)))..(.(((((......)))...)).)))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).))..)))....((((.(...).)))).(..((((((.........))))))..)...((((.[[......((((.....((..]])).......))))..))))..).)))))))..........((([[...(.((((...(((.(((((((.((.((((((......(((((((.....)))))))....))))))...)))))))))..(((((((.....(((((((((..(((((((....((........)).......)))))))..)).......((....)).)))))))....))).)))..))))...))))....((((((...))))))..........((((((..((...(((((((((.....)))))))))...))...((..]])).....)))))))))).(.(......((((....))))....).)...]]]...(.....((.(((...(.((((.(..((((.(((((......((........))..........(((......((..((.......((.(((.......))).))....))...))....(.((....((((((.(....((((((.(......)....(((......)))...))))))....(((((.(((((((.........(((((....)))).).......)))))))..(..(((((....))))).....)..)))))....).).)))...))..)).).....)))...)).))).)))).(...(((((((......((..((..((((....))))..))....)).....)))))))......(....(((((((........)))))))....)..)..).)))).....(((((((.......))))))).......)....))).))...)... Structural basis of translation inhibition by a valine tRNA-derived fragment; RNA (1328-MER) 8wq4 VTRF 26 4.53 38599770 2246 ggguugguggucuagucugguuauga ..........<<............>> ..........((............)) Structural basis of translation inhibition by a valine tRNA-derived fragment; RNA (26-MER) 8wv1 A 2871 3.99 RF02540,RF02541,RF02543,RF00002 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<.<<......<<<<<<.((..((.>>>.....<<<<<<<..<<.))..))..>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>....<<<<<.....<......>......>>>>>...........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..<<<<>>>>>..>>>.......>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<.<........>.>.<<<<<<....<<<<<<.<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<....<...........>....>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><<<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>.>>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..((((...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>>....<<<..>>>......>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<..<<...............<<<<<....<....>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<..<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<.........>>>>>........<...........<<<<<.......>>>>>.....>.....>>>>..>>.>>>>>>>.....>>..>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<..<<<<<<<<<<<<<<<<...........<<<<...<<<......<<<<<<<......>>>>>>>...>>>.............>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>.....>>>>.>>>..>>>>>..<<<<....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..>>>>..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<<..<<.......>>>..>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))))>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((.((((.((((......((((((.[[..[[.))).....((((((...(.(]]..]]..))......))))))...))).....((....)).((((((((....)))))))).(((((..))))).).)..((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...((((((((.....))))))))....[.(((((((((..(((...(((((.((((.(((...(((((......)))))[[......(((.....]])))...)))...))))..)))))..))))))))).))))....(((((((((.......)))))))))....]..((((..[[[.))))...)))......))..))))..))...............((....))....)).........((((....)))).............).....)))))))))).....(.(((((((((((..)))))))))))...(.(........).).((((((....((((((..(((((....(...(((.....)))...).....((....))..((((.....))))...(((())))...)))))..))))))..((.(....(((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..)))).)......).))..((((((....(((.(....).))).((((((((.([..(.((((((....(((...((.(((((.(...(((........)))...)..))))).))..)).)....)))))).)..).]))))))).)...(((((((.((......)).)))))))......((......))....((((.(((...((([[[...(.((((((.....(.....((..((((.(.(((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...))).).)))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))((((.((...(((......(((((.(((....))))))))...)))..)).)).)).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...)).....(((........)))..]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((....(((((((((((((((.((.....))))))))).....))))))))...)))(...(((..))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((.(.((..(....(........((((....(.{..).....)))).(((((.((((((.....))))).))))))(...).......(((((((((.].((.........))....(((((......(((....)))........)))))..}((((.(((..(.(((((....(...((...(((((....)))))...))...)..)))))...))))((((...........))))........((...........(.((.......)).)...)..)....))))...)).))))))).)..)))..))))))).)))))).....)).[..(((((......].)))))..((((((((.(((.........((((.((((((..(((((.(((.(((((.((((((.(((((((((.(......[..(((....(((......(.((((((....)))))).)...)))..........]...)))).))))))))).))))))...(((((....)))))....))))).)))..)))))..(((.....[)))((((............]..))))([.(...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).((......)).).]]].].....(((((((.((...]]]..))))))))).....)}......))))..)))))).......((((.(.((((((...(.........)...))))))...)))).)........((((..(((((..(((.(((((......)))))...))).((((.......)))).....)))))......))).).....(.(((((....))).)).)..>.....)))))))))))[...(((((((...((((..((((((......(....).....)))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..((((.))))....(((((((((.......)))))....(((((((...((....(((((....)))))...))....)))).)))...))))....))) Ambient Temperature Structure of 50S Ribosomal Subunit from Thermus Thermophilus; 23S rRNA 8wv1 B 120 3.99 RF00001 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>..>>>>>>>>>> .((.(((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((...(((....)))...)).......))).))))))).)). Ambient Temperature Structure of 50S Ribosomal Subunit from Thermus Thermophilus; 5S rRNA 8wv1 a 2871 3.99 RF02540,RF02541,RF02543,RF00002 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu 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Ambient Temperature Structure of 50S Ribosomal Subunit from Thermus Thermophilus; 23S rRNA 8wv1 b 120 3.99 RF00001 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<...<.<.<<<<<<<<....>>>>>>>>...>.>.>>>.>>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Ambient Temperature Structure of 50S Ribosomal Subunit from Thermus Thermophilus; 5S rRNA 8x0s A 11 2.956 38860430 9606 ggggccggggc ........... ........... Crystal structure of r(G4C2)2; RNA (5'-R(*GP*GP*GP*GP*CP*CP*GP*GP*GP*GP*C)-3') 8x0s B 11 2.956 38860430 9606 ggggccggggc ........... ........... Crystal structure of r(G4C2)2; RNA (5'-R(*GP*GP*GP*GP*CP*CP*GP*GP*GP*GP*C)-3') 8xc1 C 30 2.21 38742627 3702 ggacgggcugggaugacagaagucgcuugg .............................. .............................. C. elegans SID1 in complex with dsRNA; RNA (50-MER) 8xc1 D 30 2.21 38742627 3702 ccaagcgacuucugucaucccagcccgucc .............................. .............................. C. elegans SID1 in complex with dsRNA; RNA (50-MER) 8xc1 E 30 2.21 38742627 3702 ggacgggcugggaugacagaagucgcuugg .............................. .............................. C. elegans SID1 in complex with dsRNA; RNA (50-MER) 8xc1 F 30 2.21 38742627 3702 ccaagcgacuucugucaucccagcccgucc .............................. .............................. C. elegans SID1 in complex with dsRNA; RNA (50-MER) 8xi2 B 86 2.6 RF00020 39415054 0000244,0000353 0005682,0046540 3055 gacgagcugaacgcgaauaucucuuucgccuuuuacuaaagagauccgcgaguuuugcucacgcagucgcaucuuuuuguggggcu .....<..<..<<<....<<<<<<<<.<.......>.>>>>>>>>..>>>..>..>.............................. ...(....(..((.....((((((((.(.......).))))))))...))..)......).......................... Cryo-EM structure of the Chlamydomonas C* complex; U5 snRNA 8xi2 F 92 2.6 RF00026 39415054 0030621 0000244,0000353 0005688,0046540 3055 nugcuucggcacaacuguuaaaauuggaaaaauacagagaagauuagcauggccccugcgcaaggaugacacgcauaaaucgagaaaugguu <<<<....>>>>.....................................<<...<<<.....>>>....>>..................... ((((....)))).....................................((..((((.....)))..).))..................... Cryo-EM structure of the Chlamydomonas C* complex; U6 snRNA 8xi2 H 40 2.6 RF00004 39415054 0045131 0000348 0005686 3055 auaccuuucucggccuuuuggcucagaucauguguaguau ........................................ ........................................ Cryo-EM structure of the Chlamydomonas C* complex; U2 snRNA 8xi2 3 34 2.6 39415054 3055 guaagagccuagcauuaguacucauacuuauccu .................................. .................................. Cryo-EM structure of the Chlamydomonas C* complex; RNA (173-mer) 8xko E 14 3.29 39737930 32630 cuacgcguagcaug .............. .............. CryoEM structure of compound HNC-1664 bound with RdRP-RNA complex of SARS-CoV-2; RNA (5'-R(P*CP*UP*AP*CP*GP*CP*GP*UP*AP*GP*CP*AP*UP*G)-3') 8xko F 16 3.29 39737930 32630 uucaugcuacgcguag ................ ................ CryoEM structure of compound HNC-1664 bound with RdRP-RNA complex of SARS-CoV-2; RNA (5'-R(P*UP*UP*CP*AP*UP*GP*CP*UP*AP*CP*GP*CP*GP*UP*AP*G)-3') 8xpo T 14 3.02 39737930 32630 aacugaagagucca .............. .............. Cryo-EM structure of Lassa virus RdRP elongation complex with the NTP form of compound HNC-1664 bound in the active site; RNA (32-MER) 8xpp B 28 3.0 39737930 32630 ggagaugaaagucuccacuagagagucg <<<<<<....>>>>>>............ ((((((....))))))............ Crystal structure of the enterovirus 71 RdRP elongation complex with the nucleoside monophosphate form of compound HNC-1664 at product position -1 (post-translocation state); RNA (35-MER) 8xsx L5 3771 2.4 RF02543 38942792 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcggcccggcggaucuuucccgcgcgggggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucgggggcccccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcgcucuccccccucccggcgcgccggggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccgggggaggccacgcgcgcgucccccgaagagggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcagacccgacgcgccacgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagcggcggcccggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcugggucggucgcggccggcgccuagcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacaugagagguguagaauaagugggaggcccccggcgcccccccgguguccccgcgaggggcccggggcgggguccgccggcccugcgggccgccggugaaauaccacuacucugaucguuuuuucacugacccggugaggcgggggggcgagccccgaggggcucucgcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccggucccccgccgggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>>..<<<<<<<<<<...<<<<<<<<.<<<....<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>>>>>>>>>>>>..>>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<<<..<<<<<<<...<<..<.....<<<<.<<<..<<<<..>>>>>>>>>>>.>..>>..>>>>...>>>>>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<.<<<<<<<<<<<<<<<...<<..<<<.<..<<<<......<<<<<<<<..>>>>>>>>.......>>>>..>>>>........>>>>>>..>>>>>>>>>>>....................<<<<<<.<<<<<<<............>>>>>>>.<<<<<<.<<<<.<<<<<<<<<<<.<<<<<.<<<<<<<...........>.>>>>>>.>>>>>.>.>>>>>>>.>>>...>>>>..>>>>.>>..<<<<<<<<<<.....>>>>>>>>.>>....>>>>>>......>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<<<<...<<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<......>>>>>>>..<<<<<...<<<..<<<..((((.((((>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>>.<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<....................<<<.<<<<<<<<<...<<<....<<<..<.<<<..<.<<.............>>.>>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.........>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<..........)))).))))...<.....>..................>>>>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<...<....>..>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<..<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<...............<<<<<....<....>.....>>>>><<.<<<<<<<<<<<..<<..........>>.......>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<......<<...<.<<<<....>>>>.>...>>...>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<<<<<<..<.................................<........................>.............................................>...>>.>>>>>>>>>>...<<<<<.....<<<<.....<..............>................<<<<<<<<<<.......>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>><<<<....>>>>>>)))].....<<<<<<<..<<<..)))))).>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<....<<<<<.................>>>>>..<<<<....<<<<...<<<.<<<<<<<]]].>>>>>..>>.>>>..>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.....<<<<<<<.<<..<<<<....<<<........<<<<<.<<<<....>>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>..............>>>>..>>>>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<.<..<<<<<......>>>>>..>>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((...((((((((((.....)))))).)))).....)))....((((((((((...((((((((..(.....((((((((..({((((......)))))....[[(...).(((....}]])))...).))))))).).))))))))..))))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....(((((((((((..(((((((...((...(....((((.(((..((.(..).))))))))))...))..))))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((.(..((((......((((((((())))))))).......))))..))))........))))))..)))))))))))....................((((((.((((((.....(.....)..)))))).((((((.((((.(((((((((((.(((((.((((.(..............).))))).)))).).))))))).)))...))))..)))).))..((((((((((.....)))))))).))..[.)))))).....))).)))))...)))))...)))))))).<((((........))))((((((....(((((((((((((..(((..((((..........)))..)..)))...((....))...((((.((......).)))))..(((((...(((..(((..[[[[.[[[[)))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((....................(((.((((((((....(((....(((..(.(((..(..................).))).)..)))..)).)....))))))...(((((((((.(......))))))))))....))))))))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((..........]]]].]]]]]..(......)....(...)........)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((..(((((((...((.....)).))))))....[[(((.((...((....(((....)))..........((.((((....(....)...))))))......))....))...(((((........)))))]]((((....(((((...(((((((....)))))))..((((....)))...(...((((((...(((((((((((((((((((((((..{{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).))).))).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((...(([...)...])........)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(..........((((....))))........)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.(.......((((.((((((..(((((.(((((((((.(((((((.((((...............................................................................................................)).)).)))))))...(((((.....((((.....((............))................((((((((((.......))))))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a..)..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}}.)))))..)).))...))))...)))).(((....((((.....}.......))))....)))..)))...).)))))).....(((((((.((..((((.(..(((........(((((.((((.(.))))).))))).......)))...(((..(((......(((.(((((((......)))))))))).....)))..)))...........)..))))..)))))))))(((((.(..(.......)..)....((.(((((((.((.....((((.(..(((((......)))))..)))))....))....)))).))).))..))))).. Cryo-EM structure of the human 80S ribosome with Tigecycline, E-tRNA, SERBP1 and eEF2; 28S rRNA 8xsx L7 120 2.4 RF00001 38942792 0003735 0005840 9606 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. Cryo-EM structure of the human 80S ribosome with Tigecycline, E-tRNA, SERBP1 and eEF2; 5S rRNA 8xsx L8 156 2.4 RF00002,RF02540 38942792 0003735 0005840 9606 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<<<<....>>>>.....<.<<<......>>.............>>>..>...>>>....<<....>><<<<<<<<<.....>>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))((((((((.......)))))))).................... Cryo-EM structure of the human 80S ribosome with Tigecycline, E-tRNA, SERBP1 and eEF2; 5.8S rRNA 8xsx S2 1740 2.4 RF01960,RF02542,RF01959,RF00177 URS00005A14E2_9606 38942792 0003735 0005840 9606 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucgcuccucucccacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgccccccguggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcgggcguccccgcccucucggccggggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggucggcccacggcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<....<<....<<<<<..................<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<........>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<<......>>>>>>>>.>>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<<..>>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....<<....<<<.<<<....>>>.>>.>.....>>......<<..<...........>..>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<.......................<<.<.............>>>...<<<<<<.<.......<<...<.......>.<<<<.......>>>>...>>......>.>>>..>>>........<.<<.<<<.<<<...............>>>.>>>.>>.>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<.......>>>>.>>>>.....>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>............<<<<<..........>>>>>...........>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<...<<.....................>>.....>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..((....((((....((.............((.....((.(((.....))).))......))......)).((((...((((........))))...))))((..(((((...(......)..)))))......)).(.((((.(((.(.....))))))))).).)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.(.(...)).)...)))))).).....(.(((...((((.]...))).))))).)...)).).....((.((.(((.(((....))).)).).).).))......((..(...........)..)).........((((([[....(.((((.....((..]])).......))))))))))..)))))).)))..[......(.([[...(.(.((...(((..(.......................((.(.............)))...((((((.(.......((..((.......)).(((.......)))....))......).)))..)))........(.((.(.(..(.................)..).).)).)....)....(((.((...(...((((..(((.((((((((...((........))......)))))))).))).......((....))...))))..)...))..))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.((.(......).)))))))).)..)))...((..]]))...))...].))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((...(...((((..((((((((((((.......)))).)))).....))))..))))..).....(((((.....)))))........)))....))).))).....).))))).....).)))))...)).)))).))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..((((.((...((.((....(...(............)....)......)).))...)).))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}........ Cryo-EM structure of the human 80S ribosome with Tigecycline, E-tRNA, SERBP1 and eEF2; 18S rRNA 8xsx CC 75 2.4 RF00005 38942792 0030533 9606 agcagaguggcgcagcggaagcgugcugggcccauaacccagaggucgauggaucgaaaccauccucugcuacca <<<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((....[..)))).(((((.......))))).....(((((..]....)))))))))))).... Cryo-EM structure of the human 80S ribosome with Tigecycline, E-tRNA, SERBP1 and eEF2; E-tRNA 8xsy L5 3771 3.0 RF02543 38942792 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcggcccggcggaucuuucccgcgcgggggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucgggggcccccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcgcucuccccccucccggcgcgccggggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccgggggaggccacgcgcgcgucccccgaagagggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcagacccgacgcgccacgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagcggcggcccggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcugggucggucgcggccggcgccuagcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacaugagagguguagaauaagugggaggcccccggcgcccccccgguguccccgcgaggggcccggggcgggguccgccggcccugcgggccgccggugaaauaccacuacucugaucguuuuuucacugacccggugaggcgggggggcgagccccgaggggcucucgcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccggucccccgccgggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>>..<<<<<<<<<<...<<<<<<<<.<<<....<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>>>>>>>>>>>>..>>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<<<..<<<<<<<...<<..<<....<<<<.<<<..<<<<..>>>>>>>>>>>>>..>>..>>>>...>>>>>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<.<<<<<<<<<<<<<<<...<<..<<<.<<.<<<<......<<<<<<<<..>>>>>>>>.......>>>>.>>>>>........>>>>>>..>>>>>>>>>>>....................<<<<<<.<<<<<<<............>>>>>>>.<<<<<<.<<<<.<<<<<<<<<<<.<<<<<.<<<<<<<...........>.>>>>>>.>>>>>.>.>>>>>>>.>>>...>>>>..>>>>.>>..<<<<<<<<<<.....>>>>>>>>.>>....>>>>>>......>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<......>>>>>>>..<<<<<...<<<..<<<..((((.((((>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<....................<<<.<<<<<<<<<...<<<....<<<..<.<<<....<<.............>>..>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<..........)))).))))...<.....>..................>>>>>>>>>....>>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<...<....>..>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<..<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<..<<..........>>.......>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.....<<.....<<<<....>>>>.....>>..>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<<<<<<..<.................................<........................>.............................................>...>>.>>>>>>>>>>...<<<<<.....<<<<.....<..............>................<<<<<<<<<<<.....>>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>><<<<....>>>>>>)))].....<<<<<<<..<<<..)))))).>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<...<<<.<<<<<<<]]].>>>>>..>>.>>>..>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.....<<<<<<<.<<..<<<<....<<<........<<<<<.<<<<....>>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>..............>>>>..>>>>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<.<..<<<<<......>>>>>..>>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((...((((((((((.....)))))).)))).....)))....((((((((((...((((((((..(.....((((((((..({((((......)))))....[[(...).(((....}]])))...).))))))).).))))))))..))))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....(((((((((((..(((((((...((..((....((((.(((..((.(..).)))))))))))..))..))))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((.(..((((......((((((((())))))))).......))))..))))........))))))..)))))))))))....................((((((.((((((.....(.....)..)))))).((((((.((((.(((((((((((.(((((.((((.(..............).))))).)))).).))))))).)))...))))..)))).))..((((((((((.....)))))))).))..[.)))))).....))).)))))...)))))...)))))))).<((((........))))((((((....(((((((((((((..(((..(((((........))))..)..)))...((....))...(((((((......)))))))..(((((...(((..(((..[.[[.[[[[)))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((....................(((.((((((((....(((....(((..(.(((..(..................).))).)..)))..)).)....))))))...(((((((((.(......))))))))))....))))))))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.....{.(((((.(((...((...([...)))...))).....(...((.]....)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((..........]]]].]].]]..(......)....(...)........)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((..(((((((...((.....)).))))))....[[(((.((...((....(((....)))..........((.((((....(....)...))))))......))....))...(((((........)))))]]((((....(((((...(((((((....)))))))..((((....)))...(...((((((...(((((((((((((((((((((((..{{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).))).))).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((...(([...)...])........)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(..........((((....))))........)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.(.......((((.((((((..(((((.(((((((((.((((((((((((...............................................................................................................)).))))))))))...(((((.....((((.....((............))................((((((((((.......))))))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a..)..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}}.)))))..)).))...))))...)))).((((...((((.....}.......))))...))))..)))...).)))))).....(((((((.((..((((.(..(((........(((((.((((.(.))))).))))).......)))...(((..(((......(((.(((((((......)))))))))).....)))..)))...........)..))))..)))))))))(((((.(..(.......)..)....((.(((((((.((.....((((.(..(((((......)))))..)))))....))....)))).))).))..))))).. Cryo-EM structure of the human 80S ribosome with Tigecycline, e-tRNA and CCDC124 (40S head Swivelled); 28S rRNA 8xsy L7 120 3.0 RF00001 38942792 0003735 0005840 9606 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. Cryo-EM structure of the human 80S ribosome with Tigecycline, e-tRNA and CCDC124 (40S head Swivelled); 5S rRNA 8xsy L8 156 3.0 RF00002,RF02540 38942792 0003735 0005840 9606 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<<<<....>>>>.....<.<<<......>>.............>>>..>...>>>....<<....>><<<<<<<<<.....>>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))(((((((((.....))))))))).................... Cryo-EM structure of the human 80S ribosome with Tigecycline, e-tRNA and CCDC124 (40S head Swivelled); 5.8S rRNA 8xsy S2 1740 3.0 RF01960,RF02542,RF01959,RF00177 URS00021ED8E3_9606 38942792 0003735 0005840 9606 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucgcuccucucccacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgccccccguggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuccgcgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcgggcguccccgcccucucggccggggcccgaagcauuuacuuugaaaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggucggcccacggcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<....<<....<<<<<..................<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<<.....>.>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<<......>>>>>>>>.>>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<<..>>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....<<<<<<<<<.<<<....>>>..>>>>>.>>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<.......................<<.<.............>>>...<<<<<<.<.......<<...<.......>.<<<<.......>>>>...>>......>.>>>..>>>........<.<<.<<<<<<<...............>>>>>>>.>>.>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<......>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<.......>>>>.>>>>.....>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<...<<<...................>>>.....>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..(.....(((((...((.............((.....((.(((.....))).))......))......)).((((...((((........))))...))))((..(((((...(......)..)))))......)).(.((((.((((......))))))))))).)))....)).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).).....(((((((((.(((....)))..))))).))))......((..(...........)..)).........((((([[....(.((((.....((..]])).......))))))))))..)))))).)))..[......(.([[...(.(.((...(((..(.......................((................))...((((((.(.......((..((.......)).(((.......)))....))......).)))..)))........(.((.(.(((((...............))))).).)).)....)....(((..((..(...((((..((..((((((((...((........))......))))))))..)).......((....))...))))..)..))...))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.((((......)))))))))).)..)))...((..]]))...))...].))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((...(...((((..((((((((((((.......)))).)))).....))))..))))..).....(((((.....)))))........)))....))).))).....).))))).....).)))))...)).)))).))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..((((.((...(((((....(.....................)......)))))...)).))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}........ Cryo-EM structure of the human 80S ribosome with Tigecycline, e-tRNA and CCDC124 (40S head Swivelled); 18S rRNA 8xsy CC 69 3.0 RF00005 38942792 0030533 9606 agcagaguggcgcagcggaagcgugcuggaacccagaggucgauggaucgaaaccauccucugcuacca <<<<<<<..<<<<.......>>>>.<<<.....>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..(((.....[...))).((((...)))).....(((((..]....)))))))))))).... Cryo-EM structure of the human 80S ribosome with Tigecycline, e-tRNA and CCDC124 (40S head Swivelled); E-tRNA 8xsz L5 3668 3.2 RF02543 38942792 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcggcccggcggaucuuucccgcgcgggggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucgggggcccccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcgcucuccccccucccggcgcgccggggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccgggggaggccacgcgcgcgucccccgaagagggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcagacccgacgcgccacgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagcggcggcccggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcugggucggucgcggccggcgccuagcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacaugagaucugaucguuuuuucacugacccggugaggcgggggggcgagccccgaggggcucucgcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccggucccccgccgggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>>..<<<<<<<<<<...<<<<<<<<.<<<....<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>>>>>>>>>>>>..>>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<<<..<<<<<<<...<<..<.....<<<<.<<<..<<<<..>>>>>>>>>>>.>..>>..>>>>...>>>>>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<<<<<<<<<<<<<<<<<...<<..<<<.<<.<<<<......<<<<<<<<..>>>>>>>>.......>>>>.>>>>>........>>>>>>..>>>>>>>>>>>....................<<<<<<.<<<<<<<............>>>>>>>.<<<<<<.<<<<.<<<<<<<<<<<.<<<<<.<<<<<<<...........>.>>>>>>.>>>>>.>.>>>>>>>.>>>...>>>>..>>>>.>>..<<<<<<<<<<.....>>>>>>>>.>>....>>>>>>.....>>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<......>>>>>>>..<<<<<...<<<..<<<..((((.((((>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<....................<<<.<<<<<<<<<...<<<....<<<..<.<<<....<<.............>>..>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<..........)))).))))...<.....>..................>>>>>>>>>....>>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<...<....>..>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<..<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<.<<<<<<<<<<<..<<..........>>.......>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.....<<.....<<<<....>>>>.....>>..>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<<<<<<<.....>.>>.>>>>>>>>>>...<<<<<.....<<<<.....<..............>................<<<<<<<<<<.......>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>><<<<....>>>>>>)))].....<<<<<<<..<<<..)))))).>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<]]].>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.....<<<<<<<.<<..<<<<....<<<........<<<<<.<<<<....>>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>..............>>>>..>>>>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<.<..<<<<<......>>>>>..>>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((...((((((((((.....)))))).)))).....)))....((((((((((...((((((((..(.....((((((((..({((((......)))))....[[(...).(((....}]])))...).))))))).).))))))))..))))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....(((((((((((..(((((((...((..((....((((.(((..((.(..).)))))))))))..))..))))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((.(..((((......((((((((())))))))).......))))..))))........))))))..)))))))))))....................((((((.((((((.....(.....)..)))))).((((((.((((.(((((((((((.(((((.(((..(..............)..)))).)))).).))))))).)))...))))..)))).))..((((((((((.....)))))))).))..[.)))))).....))).)))))...)))))...)))))))).<((((........))))((((((....(((((((((((((..(((..(((((........))))..)..)))...((....))...((((.((......).)))))..(((((...(((..(((..[[[[.[[[[)))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((....................(((.((((((((....(((....(((..(.(((..(..................).))).)..)))..)).)....))))))...(((((((((.(......))))))))))....))))))))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.....{.(((((.(((...((...([...)))...))).....(...((.]....)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((..........]]]].]]]]]..(......)....(...)........)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((..(((((((...((.....)).))))))....[[(((.((...((....(((....)))..........((.((((....(....)...))))))......))....))...(((((........)))))]]((((....(((((...(((((((....)))))))..((((....)))...(...((((((...(((((((((((((((((((((((..{{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).))).))).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((...(([...)...])........)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((............((((....)))).........))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.(.......((((.((((((..(((((.(((((((((.((((((((((((..(.)...)).))))))))))...(((((.....((((.....((............))................((((((((((.......))))))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a..)..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}}.)))))..)).))...))))...)))).((((...((((.....}.......))))...))))..)))...).)))))).....(((((((.((..((((.(..(((........(((((.((((.(.))))).))))).......)))...(((..(((.....((((.(((((((......)))))))))))....)))..)))...........)..))))..)))))))))(((((.(..(.......)..)....((.(((((((.((.....((((.(..(((((......)))))..)))))....))....)))).))).))..))))).. Cryo-EM structure of the human 80S ribosome with Tigecycline, E-tRNA and P-tRNA; 28S rRNA 8xsz L7 120 3.2 RF00001 38942792 0003735 0005840 9606 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. Cryo-EM structure of the human 80S ribosome with Tigecycline, E-tRNA and P-tRNA; 5S rRNA 8xsz L8 156 3.2 RF00002,RF02540 38942792 0003735 0005840 9606 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<<<<....>>>>.....<.<<<......>>.............>>>..>...>>>....<<....>><<<<<<<<<.....>>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))(((((((((.....))))))))).................... Cryo-EM structure of the human 80S ribosome with Tigecycline, E-tRNA and P-tRNA; 5.8S rRNA 8xsz S2 1740 3.2 RF01960,RF02542,RF01959,RF00177 URS00021ED8E3_9606 38942792 0003735 0005840 9606 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucgcuccucucccacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgccccccguggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuccgcgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcgggcguccccgcccucucggccggggcccgaagcauuuacuuugaaaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggucggcccacggcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<..<.....<<<.<....<<....<<<<...................<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<<.....>.>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<<......>>>>>>>>..>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>>>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....<<<<<<<<<.<<<....>>>..>>>>>.>>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<.......................<<.<.............>>>...<<<<<<.<.......<<...<.......>.<<<<.......>>>>...>>......>.>>>..>>>........<.<<.<<<<<<<...............>>>>>>>.>>.>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<.......>>>>.>>>>.....>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<...<.<<<<<..........>>>>>>....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<...<<<...................>>>.....>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..((....((((....((.............((.....((.(((.....))).))......))......)).((((...((((........))))...))))((..(((((...(......)..)))))......)).(.((((.((((......))))))))).).)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).).....(((((((((.(((....)))..))))).))))......((..(...........)..)).........((((([[....(.((((.....((..]])).......))))))))))..)))))).)))..[......(.([[...(.(.((...(((..(.......................((................))...((((((.(.......((..((.......)).(((.......)))....))......).)))..)))........(.((.(.(((((...............))))).).)).)....)....(((..((..(...((((..((..((((((((...((........))......))))))))..)).......((....))...))))..)..))...))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.((((......)))))))))).)..)))...((..]]))...))...].))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((...(...((((..((((((((((.(.......).)).)))).....))))..))))..).....(((((.....)))))........)))....))).))).....).))))).....).)))))...)).)))).))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..((((.((...(((((....(.....................)......)))))...)).))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}........ Cryo-EM structure of the human 80S ribosome with Tigecycline, E-tRNA and P-tRNA; 18S rRNA 8xsz CC 75 3.2 RF00005 38942792 0030533 9606 agcagaguggcgcagcggaagcgugcugggcccauaacccagaggucgauggaucgaaaccauccucugcuacca <<<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..(((.....[...))).(((((.......))))).....(((((..]....)))))))))))).... Cryo-EM structure of the human 80S ribosome with Tigecycline, E-tRNA and P-tRNA; tRNA 8xsz CD 75 3.2 RF00005 38942792 0030533 9606 agcagaguggcgcagcggaagcgugcugggcccauaacccagaggucgauggaucgaaaccauccucugcuacca <<<<<<<..<<<<.......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((.(((..(((.....[...))).(((((.......))))).....(((((..]....)))))))).))).... Cryo-EM structure of the human 80S ribosome with Tigecycline, E-tRNA and P-tRNA; tRNA 8xsz CE 11 3.2 38942792 9606 uuauaugaugu ........... ........... Cryo-EM structure of the human 80S ribosome with Tigecycline, E-tRNA and P-tRNA; mRNA 8xt0 L1 1500 3.2 RF02541 38942792 0003735 0005840 9606 gcuaaaccuagccccaaacccacuccaccuuacuaccagacaaccuuagccaaaccauuuacccaaauaaaguauaggcgauagaaauugacuggcgcaauagauauaguaccgcaagggaaagaugaaaaauuauaaccaagcauaauauagcaaggacuaaccccuauaccuucugcauaaugaauuaacuagaaauaacuuugcaaggagagccaaagcuaagacccccgaaaccagacgagcuaccuaagaacagcuaaaagagcacacccgucuauguagcaaaauagugggaagauuuauagguagaggcgacaaaccuaccgagccuggugauagcugguuguccaagauagaaucuuaguucaacuuuaaauuugcccacagaaccaaauccccuuguaaauuuaacuguuaguccaaagaggaacagcucuuuggacacuaggaaaaaaccuuguagagagaguaaaaaauuuaacacccauaguaggccuaaaagcagccaccaauuaagaaagcguucaagcucaacacccacuaccuaaaaaaucccaaacauauaacugaacuccucacacccaauuggaccaaucuaucacccuauagaagaacuaauguuaguauaaguaacaugaaaacauucuccuccgcauaagccugcgucagaucacacugacaauuaacagcccaauaucuacaaucaaccaacaagucauuauuacccucacugucaacccaacacaggcaugcucauaaggaaagguuaaaaaaaguaaaaggaacucggcaaaucuuaccccgccuguuuaccaaaaacaucaccucuagcaucaccaguauuagaggcaccgccugcccagugacacauguuuaacggccgcgguacccuaaccgugcaaagguagcauaaucacuuguuccuuaaauagggaccuguaugaauggcuccacgaggguucagcugucucuuacuuuuaaccagugaaauugaccugcccgugaagaggcgggcauaacacagcaagacgagaagacccuauggagcuuuaauuuauuaaugcaaacaguaaccugcauuaaaaauuucgguuggggcgaccucggagcagaacccaaccuccgagcaguacaugcuaagacuucaccagucaaagcgaaccucaauugauccaauaacuugaccaacggaacaaguuacccuagggauaacagcgcaauccuauucuagaguccauaucaacaauaggguuuacgaccucgauguuggaucaggacaucccgauggugcagccgcuauuaaagguucguuuguucaacgauuaaaguccuacgugaucugaguucagaccggaguaauccaggucgguuucuaucuacuuuaaauuccucccuguacgaaaggacaagagaaauaaggccuacuucacaaagcgccuucccccguaaaugauaucaucucaacuuagauacccacacccacccaagaacaggguu <<<.......<<<<.....................................<......>...............<<.....>>..........>>.>>.............<<....>>......................>>>...........<<<.......>>>...<.<........>.>.<<<<<<.........<<<.<<..<<....>>...>>.>>>...<<.<...<<<<.<.....<<<<<.<<<..<<<.....>>>...<<<..<<<<........>>>>.>>>....>>>.>>>>>...<<.......>>......>.>>>>......>.>>..<<<<<<....<<<<....>>>><<<.<<<<<<<<<<.....<<......>>.....>>>>>>>>>>..>>>.<<<<<<<<<<......>>>>>>>>>>...<<<......>>>....<<<.<<<...<..............<....<<<.........>>>....>.......<<<......>>>....................................>...>>>>>>........>>>>>>...<<<<<......>>>>>.........>>>>>><......<<..<<<....>>><<<<..<<<<........<<<<<......>>>>>......<<<...<<<<.......................>>>>.......>>>.....<<......>>.>>>>.....>>>>..<<<<...<<<<<<<<.<<.........<......<<<<<<..<<<.........>>>...<<<<<<.............>>>>>>....<<<.<<<..<<<<<....>>>..>>>>><<<<<<......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>....>>.>>>>.....>..>>.>>>>>>>>>>>>.>>.....>.....<<<<<........>>>>>.......<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<..........>>>>>>>>>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<.....<<<..<<<<.....>>>>..>>>....>>.........<<<....>>>............>>>>..>>>>>>.......<<<..<.<<<<<<...<<.......>>...>>>>>>...>.>>.>.......<<<<<.<<<<<<..<<.<<<<<<......>>>>>>...>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>....<<<.<<<.................>>>.>>><<<<<...<<<....>>>.>>>>>......<<<................>>>.............<<<<.......>>>>. ((.....(..((((.....................................(...[..).........(.....((.]...))....).....)).)).............((....))....).....(...)........)).........(.(((.......))).[.(.(........).).((((((.........(((.((..((....))...)).)))...((.(...((((.(.....(((((.((((.(((....[)))...(((..((((.......{)))).)))..).))).))))).(.((.......))...)..).))))......).))..((((((....((((....)))).((.((((((((((.....((......)).....))))))))))..))..((((((((((......))))))))))...(((......)))....(((.(((...(..............(.(..(((.........)))..).)....(..(((......))))...................................)...))))))........))))))...(((((......))))).........))))))(......((..(((....)))(((...((((......(.(((((......)))))......(((...((((...............(..)....)))).......))).)...((......)).))))......)))..((((....(((((((.((..(....(........((((((.].((.........))....((((((.............))))))....(((.(((..(((((....)))..)))))(((((........)))))........((..........(((((.......)))))..)..)....)))....)).))))....)..))).))))))).)))).)).....)).{..(((((.....]}.))))).......((..(((.((......((((.((((((..(((((.((((((((..........)))))))))))))..(((......[)))((((((..........]))))))(.((.....((...(((....[..)))...))....)).........(((....))).....)].....))))..))))))......((((..(.((((((.(.((.......)))..))))))...).)).).)......((((.((((((..((.((((((......))))))...)).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..}.))..))).))..(.(((.(((......(....).....))).)))(((((...(((....))).)))))......(((................)))..)..........((((.......)))). Cryo-EM structure of the human 55S mitoribosome with 5um Tigecycline; 16s rRNA 8xt0 S1 928 3.2 RF00177 URS00021ED90F_9606 38942792 0003735 0005840 9606 auagguuugguccuagccuuucuauuagcucuuaguaagauuacacaugcaagcauccccguuccagugaguucacccucuaaaucgaucaaaaggaacaagcaucaagcacgcagcaaugcagcucaaaacgcuuagccuagccacacccccacgggaaacagcagugauuaaccuuuagcaauaaacgaaaguuuaacuaagcuauacuaaccccaggguuggucaauuucgugccagccaccgcggucacacgauuaacccaagucaauagaaccggcguaaagaguguuuuagaucacaauaaagcuaaaacucaccugaguuguaaaaaacuccaguugacacaaaauagacuacgaaaguggcuuuaacauaucugaacacacaauagcuaagacccaaacugggauuagauaccccacuaugcuuagcccuaaaccucaacaguucaacaaaacugcucgccagaacacuacgagccacagcuuaaaacucaaaggaccuggcggugcuucauaucccucuagaggagccuguucuguaaucgauaaaccccgaucaaccucaccaccucuugcucagccuauauaccgccaucuucagcaaacccugaugaaggcuacaaaguaagcgcaaguacccacguaaagacguuaggucaagguguagcccaugagguggcaagaaaugggcuacauuuucuaccccagaaacgauagcccuuaugaaauaagggucgaagguggauuuagcaguaaacuaagaguagagugcuuaguugaacagggcccugaagcgcguacacaccgcccgucacccuccucaaguauacuucaaaggacaauuaacuaaaaccccuacgcauuuauauagaggagacaagucguaacaugguaaguguacuggaaagugcacuuggacgaac ..((((..<<<<<<.)))).<<<<<<.<<..<<<<<<<<..<.<<<.<<<..<......>......<<........<<<....<<..>>....>>>...<<<<....<<...<<<....>>>..>>......>>>>.<<...>>.>>.<<<....>>>.....>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>.....<<<<<<<<.....(((.....((.>>>)).......)))..>>>>>..>>.>>>>>>...<<<((.....<<<<..<<<<......<<<<<<......<<<.<<<.<<<......>>>..>>>.>>>.............<<....>>.>>>>>>.....>>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<.<<<<<..))..>>>>>.>.>>>.<<.......<<<<....>>>>.....>>..>>>>>><<<<<.<<<<<<<...<<<.<<<<<..<<<<<<<<<<.....<<........>>..........<<<<<<<.......<<.<<<..<<<<<<.......<<..<<<<<.....>>>.......>>..>>.....<<<....>>>.........>>>...>>>>>>>>....>>>>>>>..>>.>>>>>>>>.....<<<<.....>>>>.<....<<<<<<<.....>>>>>>>....>.....>>>>>.....<<<<<<<.........>>>>>>>.....>>>...>>>>>>>>>>.>>....<..<<.<...<<<<<<..<<<<<......<<<....<<.....>>...>>>.......>>>>>.>>>>>>....>.>>...>.....<<<<<<<<<....>>>>>>>>>........ [.[[[[..(((((..]]]]]((((((.((..((((((((..(.(((.(((..(......)......(((.......(((.(..((())).)..)))...((((....((..((((....))).)))......)))).((...))))).(((....))).....)))))))......(.(((...(((((....)))).))))).)).)))))).....((((([[[.....(((.....((.]]])).......)))..)))))..)).))))))...((([[...(.((((...(((......(((((((.....(((.(((.((........))..))).))).....).....(.((....))))))))).....)))....))))....((((((...((...((((.........))))...))))))))......{...(.(((((..]]..))))).))))).((.......((((....)))).....))...)))))(((((.(((((((...(((.(((((..((((((((((.....((........))..........(((((((.......((.(((...((.(((.(....((..(((((.....))).......))..)).....(((....))).....).).))....)).)))).)...)))))))..)).)))))))).(...((((.....))))......(((((((.....))))))).......)..))))).....(((((((.........))))))).....)))...)))))))))).))..(.(..((.(...((((((...((((..((..(((....((.....))...)))..).)..))))..))))))....).))...)..)..(((((((((....)))))))))}....... Cryo-EM structure of the human 55S mitoribosome with 5um Tigecycline; 12s rRNA 8xt2 L1 1500 3.3 RF02541 38942792 0003735 0005840 9606 gcuaaaccuagccccaaacccacuccaccuuacuaccagacaaccuuagccaaaccauuuacccaaauaaaguauaggcgauagaaauugacuggcgcaauagauauaguaccgcaagggaaagaugaaaaauuauaaccaagcauaauauagcaaggacuaaccccuauaccuucugcauaaugaauuaacuagaaauaacuuugcaaggagagccaaagcuaagacccccgaaaccagacgagcuaccuaagaacagcuaaaagagcacacccgucuauguagcaaaauagugggaagauuuauagguagaggcgacaaaccuaccgagccuggugauagcugguuguccaagauagaaucuuaguucaacuuuaaauuugcccacagaaccaaauccccuuguaaauuuaacuguuaguccaaagaggaacagcucuuuggacacuaggaaaaaaccuuguagagagaguaaaaaauuuaacacccauaguaggccuaaaagcagccaccaauuaagaaagcguucaagcucaacacccacuaccuaaaaaaucccaaacauauaacugaacuccucacacccaauuggaccaaucuaucacccuauagaagaacuaauguuaguauaaguaacaugaaaacauucuccuccgcauaagccugcgucagaucacacugacaauuaacagcccaauaucuacaaucaaccaacaagucauuauuacccucacugucaacccaacacaggcaugcucauaaggaaagguuaaaaaaaguaaaaggaacucggcaaaucuuaccccgccuguuuaccaaaaacaucaccucuagcaucaccaguauuagaggcaccgccugcccagugacacauguuuaacggccgcgguacccuaaccgugcaaagguagcauaaucacuuguuccuuaaauagggaccuguaugaauggcuccacgaggguucagcugucucuuacuuuuaaccagugaaauugaccugcccgugaagaggcgggcauaacacagcaagacgagaagacccuauggagcuuuaauuuauuaaugcaaacaguaaccugcauuaaaaauuucgguuggggcgaccucggagcagaacccaaccuccgagcaguacaugcuaagacuucaccagucaaagcgaaccucaauugauccaauaacuugaccaacggaacaaguuacccuagggauaacagcgcaauccuauucuagaguccauaucaacaauaggguuuacgaccucgauguuggaucaggacaucccgauggugcagccgcuauuaaagguucguuuguucaacgauuaaaguccuacgugaucugaguucagaccggaguaauccaggucgguuucuaucuacuuuaaauuccucccuguacgaaaggacaagagaaauaaggccuacuucacaaagcgccuucccccguaaaugauaucaucucaacuuagauacccacacccacccaagaacaggguu <<<.......<<<<.....................................<......>...............<<.....>>..........>>.>>.............<<....>>......................>>>...........<<<.......>>>...<.<........>.>.<<<<<<.........<<<.<<..<<....>>...>>.>>>...<<.<...<<<<.<.....<<<<<.<<<..<<<.....>>>...<<<..<<<<........>>>>.>>>....>>>.>>>>>...<<.......>>......>.>>>>......>.>>..<<<<<<....<<<<....>>>><<<.<<<<<<<<<<.....<<......>>.....>>>>>>>>>>..>>>.<<<<<<<<<<......>>>>>>>>>>...<<<......>>>....<<<.<<<...<..............<....<<<.........>>>....>.......<<<......>>>....................................>...>>>>>>........>>>>>>...<<<<<......>>>>>.........>>>>>><......<<..<<<....>>><<<<..<<<<........<<<<<......>>>>>......<<<...<<<<.......................>>>>.......>>>.....<<......>>.>>>>.....>>>>..<<<<...<<<<<<<<.<<.........<......<<<<<<..<<<.........>>>...<<<<<<.............>>>>>>....<<<.<<<..<<<<<....>>>..>>>>><<<<<<......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>....>>.>>>>.....>..>>.>>>>>>>>>>>>.>>.....>.....<<<<<........>>>>>.......<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<..........>>>>>>>>>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<.....<<<..<<<<.....>>>>..>>>....>>.........<<<....>>>............>>>>..>>>>>>.......<<<..<.<<<<<<...<<.......>>...>>>>>>...>.>>.>.......<<<<<.<<<<<<..<<.<<<<<<......>>>>>>...>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>....<<<.<<<.................>>>.>>><<<<<...<<<....>>>.>>>>>......<<<................>>>.............<<<<.......>>>>. ((.....(..((((.....................................(...[..).........(.....((.]...))....).....)).)).............((....))....).....(...)........)).........(.(((.......))).[.(.(........).).((((((.........(((.((..((....))...)).)))...((.(...((((.(.....(((((.((((.(((....[)))...(((..((((.......{)))).)))..).))).))))).(.((.......))...)..).))))......).))..((((((....((((....)))).((.((((((((((.....((......)).....))))))))))..))..((((((((((......))))))))))...(((......)))....(((.(((...(..............(.(..(((.........)))..).)....(..(((......))))...................................)...))))))........))))))...(((((......))))).........))))))(......((..(((....)))(((...((((......(.(((((......)))))......(((...((((...............(..)....)))).......))).)...((......)).))))......)))..((((....(((((((.((..(....(........((((((.].((.........))....((((((.............))))))....(((.(((..(((((....)))..)))))(((((........)))))........((..........(((((.......)))))..)..)....)))....)).))))....)..))).))))))).)))).)).....)).{..(((((.....]}.))))).......((..(((.((......((((.((((((..(((((.((((((((..........)))))))))))))..(((......[)))((((((..........]))))))(.((.....((...(((....[..)))...))....)).........(((....))).....)].....))))..))))))......((((..(.((((((.(.((.......)))..))))))...).)).).)......((((.((((((..((.((((((......))))))...)).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..}.))..))).))..(.(((.(((......(....).....))).)))(((((...(((....))).)))))......(((................)))..)..........((((.......)))). Cryo-EM structure of the human 55S mitoribosome with 10uM Tigecycline; 16s rRNA 8xt2 S1 928 3.3 RF00177 URS00021ED90F_9606 38942792 0003735 0005840 9606 auagguuugguccuagccuuucuauuagcucuuaguaagauuacacaugcaagcauccccguuccagugaguucacccucuaaaucgaucaaaaggaacaagcaucaagcacgcagcaaugcagcucaaaacgcuuagccuagccacacccccacgggaaacagcagugauuaaccuuuagcaauaaacgaaaguuuaacuaagcuauacuaaccccaggguuggucaauuucgugccagccaccgcggucacacgauuaacccaagucaauagaaccggcguaaagaguguuuuagaucacaauaaagcuaaaacucaccugaguuguaaaaaacuccaguugacacaaaauagacuacgaaaguggcuuuaacauaucugaacacacaauagcuaagacccaaacugggauuagauaccccacuaugcuuagcccuaaaccucaacaguucaacaaaacugcucgccagaacacuacgagccacagcuuaaaacucaaaggaccuggcggugcuucauaucccucuagaggagccuguucuguaaucgauaaaccccgaucaaccucaccaccucuugcucagccuauauaccgccaucuucagcaaacccugaugaaggcuacaaaguaagcgcaaguacccacguaaagacguuaggucaagguguagcccaugagguggcaagaaaugggcuacauuuucuaccccagaaacgauagcccuuaugaaauaagggucgaagguggauuuagcaguaaacuaagaguagagugcuuaguugaacagggcccugaagcgcguacacaccgcccgucacccuccucaaguauacuucaaaggacaauuaacuaaaaccccuacgcauuuauauagaggagacaagucguaacaugguaaguguacuggaaagugcacuuggacgaac ..((((..<<<<<<.)))).<<<<<<.<<..<<<<<<<<..<.<<<.<<<..<......>......<<........<<<....<<..>>....>>>...<<<<....<<...<<<....>>>..>>......>>>>.<<...>>.>>.<<<....>>>.....>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>.....<<<<<<<<.....(((.....((.>>>)).......)))..>>>>>..>>.>>>>>>...<<<((.....<<<<..<<<<......<<<<<<......<<<.<<<.<<<......>>>..>>>.>>>.............<<....>>.>>>>>>.....>>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<.<<<<<..))..>>>>>.>.>>>.<<.......<<<<....>>>>.....>>..>>>>>><<<<<.<<<<<<<...<<<.<<<<<..<<<<<<<<<<.....<<........>>..........<<<<<<<.......<<.<<<..<<<<<<.......<<..<<<<<.....>>>.......>>..>>.....<<<....>>>.........>>>...>>>>>>>>....>>>>>>>..>>.>>>>>>>>.....<<<<.....>>>>.<....<<<<<<<.....>>>>>>>....>.....>>>>>.....<<<<<<<.........>>>>>>>.....>>>...>>>>>>>>>>.>>....<..<<.<...<<<<<<..<<<<<......<<<....<<.....>>...>>>.......>>>>>.>>>>>>....>.>>...>.....<<<<<<<<<....>>>>>>>>>........ [.[[[[..(((((..]]]]]((((((.((..((((((((..(.(((.(((..(......)......(((.......(((.(..((())).)..)))...((((....((..((((....))).)))......)))).((...))))).(((....))).....)))))))......(.(((...(((((....)))).))))).)).)))))).....((((([[[.....(((.....((.]]])).......)))..)))))..)).))))))...((([[...(.((((...(((......(((((((.....(((.(((.((........))..))).))).....).....(.((....))))))))).....)))....))))....((((((...((...((((.........))))...))))))))......{...(.(((((..]]..))))).))))).((.......((((....)))).....))...)))))(((((.(((((((...(((.(((((..((((((((((.....((........))..........(((((((.......((.(((...((((((.(....((..(((((.....))).......))..)).....(((....))).....).).)))...)).)))).)...)))))))..)).)))))))).(...((((.....))))......(((((((.....))))))).......)..))))).....(((((((.........))))))).....)))...)))))))))).))..(.(..((.(...((((((...((((..((..(((....((.....))...)))..).)..))))..))))))....).))...)..)..(((((((((....)))))))))}....... Cryo-EM structure of the human 55S mitoribosome with 10uM Tigecycline; 12s rRNA 8xtp B 595 2.9 39890981 399795 gggcgaccgugaaacggcgcugggcaggaaauggcccagugaccuggucaauggugaaagucggugaaagaccgaccgguggggcguaucgaaagagcgcaacaccugccgcacaggauggcuucugagguaccggugacgguacagaacgcggaggggaaaccuggaagcgagggcaccucgggaaaccgggggucgaugcauagcucaaaccuguaacggcaccaguggagggugcugugcggagcaacguggagccacaggcaugaagccgugguucguagucgaugagacaagcggugaguaagggaagggcugcgaacaucgccuccccgaaauccaaggaaagccgaaaggcuagccgcuuuguugagacaguggcgccacguugcgcauuagccgugaccuaaacggggaaccucuuggccguaccgacucggguggcaccggucgggcucgauggcucaagagggggagaugugaugauuaggguuugacccgugaugcgauacgaccgaagcauccggggagcugucugacgaagagucggcagcaguggguuuggcgacccgcuccgaaagucgcaagcguuugc ..((..<<<<.....<<<<<<<<<<........>>>>>>>>.>>.<<<<<.<<<<....<<<<<.......>>>>>.<<<<..<<<<.<<....>>>>>>..>>>>..<<<<<<<<<.<....<<....<<<<<<....>>>>>>....<<<...<<<....>>>....>>>..<<<.<<<<<<....>>>>>>>>>>>......))....>>>>>....<<<<<<.......>>>>>>.>>>>>.<<<<<<<<<.<<<<<.<<<.....>>>..[[.((((.<<<.....<<<<<<<<<<......<<<.<<<.<.<.......>>>>>>>>.....<<<..>>>..<<<....>>>..>>>>>.>>>>>..>>>.>>>>>.>>>>>>>>>......>>>>>>>>>...>>>>....<<<<<<<<<<<<..<<<<.<<<......>>>>>>>......>>>>>.>>>>>>>......<<<<<<.....<<......<<<<.<<<<<...))))]]...>>>>>>>>>..<<<<.<<<<<.....>>>>>>>>>.<<<<<<......>>>>>>.>>....>>>>>>......... ..[[..((((.....((((((((((........)))))))).)).(((((..(((....(((((.......)))))(((((..((((.((....))))))..)))).)(((((((((.(..(.((....((((((....))))))....(((...(((....)))....)))..(((.((((((....))))))))))).)....]]....)))))....((((((.......)))))).))))).(((((((((.(((((.(((.....)))..[[.[[[[.(((.....((((((((((......(((.(((...(.......).)))))).....((....))..(((....)))..))))).)))))..))).))))).)))))))))......))).)))))...))))....((((((((((.(.(((((.(((......)))))))).....).))).)))))))......((((((.....((......((((.(((((...]]]]]]...)))))))))..((((.(((((.....))))))))).((((((......)))))).))....))))))......... Comamonas testosteroni KF-1 circularly permuted group II intron Post-2S state; RNA (595-MER) 8xtp A 133 2.9 39890981 399795 ccggggcgccaccccggaagugaugcgagucgccaacucgcaucacaagcaaacgcuguagccgcgugccucuaauagggcuggcgcgguugcgaagggcgcuggugagugcaacucucaccuucgacccaau <<<<<<.....>>>>>>..<<<<<<<<<<<.....>>>>>>>>>>>...........<<.<<<<<<<<<<<......>>>>..>>>>>>>.>>...<<<<<..<<<<<<.......>>>>>>..>>.>>>... ((((((.....))))))..(((.(((((((.....))))))).)))...........((((((((((((((......))))..))))))))))...(((((..((((((.......))))))..)).)))... Comamonas testosteroni KF-1 circularly permuted group II intron Post-2S state; RNA (133-MER) 8xtr A 145 2.67 39890981 399795 ccggggcgccaccccggaagugaugcgagucgccaacucgcaucacaagcaaacgcuguagccgcgugccucuaauagggcuggcgcgguugcgaagggcgcuggugagugcaacucucaccuucgacccaauccaauugaaguu <<<<<<.....>>>>>>..<<<.<<<<<<.......>>>>>>.>>>...........<<<<<<<<<<<<<<......>>>>..>>>>>>>>>>...<<<<<..<<<<<<.......>>>>>>..>>.>>>............... ((((((.....))))))...((.(((((((.....))))))).))............((((((((((((((......))))..))))))))))...(((((..((((((.......))))))..)).)))............... Comamonas testosteroni KF-1 circularly permuted group II intron 2S state; RNA (219-MER) 8xtr B 595 2.67 39890981 399795 gggcgaccgugaaacggcgcugggcaggaaauggcccagugaccuggucaauggugaaagucggugaaagaccgaccgguggggcguaucgaaagagcgcaacaccugccgcacaggauggcuucugagguaccggugacgguacagaacgcggaggggaaaccuggaagcgagggcaccucgggaaaccgggggucgaugcauagcucaaaccuguaacggcaccaguggagggugcugugcggagcaacguggagccacaggcaugaagccgugguucguagucgaugagacaagcggugaguaagggaagggcugcgaacaucgccuccccgaaauccaaggaaagccgaaaggcuagccgcuuuguugagacaguggcgccacguugcgcauuagccgugaccuaaacggggaaccucuuggccguaccgacucggguggcaccggucgggcucgauggcucaagagggggagaugugaugauuaggguuugacccgugaugcgauacgaccgaagcauccggggagcugucugacgaagagucggcagcaguggguuuggcgacccgcuccgaaagucgcaagcguuugc ..((..<<<<.....<<<<<<<<<<........>>>>>>>>.>>.<<<<<.<<<<....<<<<<.......>>>>>.<<<<..<<<<.<<....>>>>>>..>>>>..<<<<<<<<<.<..<.<<....<<<<<<....>>>>>>....<<<...<<<....>>>....>>>..<<<.<<<<<<....>>>>>>>>>>>.>....))....>>>>>....<<<<<<.......>>>>>>.>>>>>.<<<<<<<<<.<<<<<.<<<.....>>>..[[.((((.<<<.....<<<<<<<<<<......<<<.<<<.............>>>>>>.....<<<..>>>..<<<....>>>..>>>>>.>>>>>..>>>.>>>>>.>>>>>>>>>......>>>>>>>>>...>>>>....<<<<<<<<<<<<..<<<<.<<<......>>>>>>>......>>>>>.>>>>>>>......<<<<<<.....<<......<<<<.<<<<<...))))]]...>>>>>>>>>..<<<<.<<<<<.....>>>>>>>>>.<<<<<<......>>>>>>.>>....>>>>>>......... ..[[..((((.....((((((((((........)))))))).)).(((((..(((....(((((.......)))))(((((..((((.((....))))))..)))).)(((((((((.(..(.((....((((((....))))))....(((...(((....)))....)))..(((.((((((....))))))))))).)....]]....)))))....((((((.......)))))).))))).(((((((((.(((((.(((.....)))..[[.[[[[.(((.....((((((((((......(((.(((.............)))))).....((....))..(((....)))..))))).)))))..))).))))).)))))))))......))).)))))...))))....((((((((((.(.(((((.(((......)))))))).....).))).)))))))......((((((.....((......((((.(((((...]]]]]]...)))))))))..(((..(((((.....))))).))).(.((((......)))).).))....))))))......... Comamonas testosteroni KF-1 circularly permuted group II intron 2S state; RNA (595-MER) 8xu8 2 1767 3.4 RF01960,RF02542,RF01959,RF00177 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggauuuccaacggggccuuuccuucuggcuaaccuugagcuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauu ...<<<<<.{.((((>>>>><<<<.<<<<<<...<.<...<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<..<<..<<....<<<..................<<....<<.<<<.....>>>.>>.....>>.........<<<<<..<<....>>..>>>>><.<.<<<<<<.....(((......<<<....>>>..............>>>>>>.>...>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>...<<<..>>>.....>>>>>>.........<<<....<<<.....>>>..>>>..>....>.>.....<<<<<<.....<......>.....>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>>.........<<<[[.....<.<<...<<<.<<....<<<<<<.<<<<..........>>>>.>>>>>>.....<<<<<....................>>>>>....<<<<<.<<.......<<...<.......>..<<<<...>>>>....>>......>>.>>..>>>.........<<<..<<<<<<<<.........))).>>>>>>>>.>>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..]]>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..)))).}<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<.<......>....<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...........<<<<<<..........>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<.<..<.<<<<....>>>>.>..>.>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>........ ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...))[))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....))..........((((..((....))..)))).(.(.((((((......{{......(........).....(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)....).).....(((...(..(.((....).).).)....)))....(.(((.(...........)).))......)..((((([[....(.((((.....((..]])).......))))))))))..))))))))))..[......((([[...(.(.((...(((.((.....(((((.(((............))).)))))......(((((....................)))))....(((((.((.......((..((.......))..((.....)).....))......)).))..))).........(....(..(.(((.........}}..))).)..)...).....))...(((..((..(...((((..(((.((((((.(...((........))......).)))))).))).......((....))...))))..)..))...))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..((((((((.(((........)))))))))))..)))...((..]]))...))...].)))))))..((......((((....))))....))....]]].].((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((.....((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((.(((....))).))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).......))))).....).)))))...)).)))).))).(...(((((((......((.....((..(.((....)).)..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....((((((((.......))))))))......))...)))))))))).)...(.(..((.(..((((.((..(.((((((((.(((..(.((..(...((.(((..(.(..((((....))))...))..))).))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}....... State 2c(S2c) of yeast 80S ribosome bound to compact eEF2 and 2 tRNAs during peptidyl transferation; 18S rRNA 8xu8 A 3189 3.4 RF02540,RF02541,RF02543 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucgaacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauagaggguguagaauaagugggagcuucggcgccagugaaauaccacuaccuuuauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuugguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<<....>>......>>>>>.>...{.....<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<.<<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.((......<<<.....))>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]....}.............................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<...<<<<<<<.<<<<<<<<<<<<<<<......<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>...>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>...>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<....<<.....>>..>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>>..<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<..........>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>...<...<<<<<<...<<<<.<<<<<<<<<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<<....>>>>>>>>>>>>.>.>>>>>>>.>>>>.........>>>>>>...>......>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<.....<..>......>>>>><<.<<<<<<<<<<<..>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<.....<<<....<<<<<....>>>>.>...>>>..>>>..>>>>><<<<<.........>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<<<<.<<.<<...........<<<......................>>>...>>>.>>>.>>>>>>>>>>...<<<<<.....<<<<..<...<.......>..>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>..>>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.<.....>.>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<...<<<<<<<<<<<}}}.>>>>>..>>>>>>..>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<..<.......>..>.....<<<<<<<<<.<<<....<<<<....<<<<<....>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................((((((.....(...[..)......))))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))).)...)))))))))))...)....(((((((........))))))).....((.((..[[[[[[)).))..)))..................................((....))............(..((((....))))............).....................(((((.(((((...(((((((((((((((((((((((.......(((((((......((((........)))).......))))))).....))))).))))))))))........(((....)))....))))))))...))))).))))).<((((........))))((((((..(.(((.((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).)).)))..((.(...((((((......(((((((((.((((...(((((((....)))))))...)<)))...(((..((.((........)))).)))..).))))))))..(.((.......))...)..))))))......).))).((((((....(.(((....))).)((((((((((....((.(((((((.....(((....(((..(.((((.....(.()..)...)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.((.((.....)).)).))))....(((......)))...(((((((...((([[[.....((((((......(..........(((.((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....)))))).)))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...((((((...((.....)).))))))....[[(((.((...((....(((....))).........(.(............)..)....))....))...(((((........)))))]]((((..(((.(((...((((....)))...(.[[((((((...((((.((((((((((((((((((...{{..))))))(...((((.....(((((.....(((.....))).....)))))......))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....)).)..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((.......(.......(((((....(.[..).....)))))((.(((((((((((..)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].((..(((..((((((.....((.....((((....)))).....))..))))..)))))(((((.........)))))........((..........(((((.......)))))..)..).....))....)).))))))).)...)).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.((((((((..((((((((((....(................(..(......)............).......).....))))))))))...(((((.....((((....(.(.......).)...........]]...((((((....))))))..))))..))))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(..(((((...((.......))...)))))....)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))....))..))).)))))....((((((((..((((.(.((((((.....(....)....)))))).)((((....((((....((((((((((}}..)))))..)))))...))))...)))).((((...((((.....}.......))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...((.((.(..(((......)))..).)).)).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(((((....)))))..)))))...)))....)))).)))))).))))).. State 2c(S2c) of yeast 80S ribosome bound to compact eEF2 and 2 tRNAs during peptidyl transferation; 25S rRNA 8xu8 B 121 3.4 RF00001 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<<............>>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..).)...)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). State 2c(S2c) of yeast 80S ribosome bound to compact eEF2 and 2 tRNAs during peptidyl transferation; 5S rRNA 8xu8 C 158 3.4 RF00002 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<(.....>>............).>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... State 2c(S2c) of yeast 80S ribosome bound to compact eEF2 and 2 tRNAs during peptidyl transferation; 5.8S rRNA 8xu8 s 75 3.4 RF00005 URS00021ED942_559292 0030533 0006412 559292 agcgccgugacgcaguggaagcgcgcagggcucauaacccugauguccucggaucgaaaccgagcggcgcuacca <<<<<<<...<<<.......>>>..<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((...(((....[..)))..(((((.......))))).....(((((..]....)))))))))))).... State 2c(S2c) of yeast 80S ribosome bound to compact eEF2 and 2 tRNAs during peptidyl transferation; tRNA 8xu8 t 75 3.4 RF00005 URS00021ED942_559292 0030533 0006412 559292 agcgccgugacgcaguggaagcgcgcagggcucauaacccugauguccucggaucgaaaccgagcggcgcuacca <<<<<<<...<<<.......>>>..<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((...(((....[..)))..(((((.......))))).....(((((..]....)))))))))))).... State 2c(S2c) of yeast 80S ribosome bound to compact eEF2 and 2 tRNAs during peptidyl transferation; tRNA 8xz3 A 3119 3.6 RF02541 39029461 0003735 0005840 246196 aaguguuuaagggcgcaugguggaugccuuggcacugggagccgaugaaggacguaggaggcugcgauaagccucggggagcugucaaccgagcguugauccgaggauguccgaauggggaaacccggcacgagugaugucgugucaccaggcgcugaauauauaggcgucuggggggaacgcggggaagugaaacaucucaguacccguaggaagagaaaacaaaaugugauuccgugaguaguggcgagcgaaagcggaggauggcuaaaccguaugcaugugauaccggguagggguugugugugcgggguugugggaccuaucuuuccggcucuaccuggcuggagggcagugagaaaauguugugguuagcggaaauggcuugggauggccugccguagacggugagagcccgguacgugaaaacccgacgucugucuugaugguguucccgaguagcagcgggcccguggaaucugcugugaaucugccgggaccacccgguaagccugaauacuucccagugaccgauagcggauuaguaccgugagggaauggugaaaaguaccccgggaggggagugaaagaguaccugaaaccgugcgcuuacaauccgucagagcccucgacgugucguggggugauggcgugccuuuugaagaaugagccugcgagucagggacaugucgcgagguuaacccgggugggguagccgcagcgaaagcgagucugaauagggcguauccacacaagagugugugguguagugguguguucuggacccgaagcggagugaucuacccauggccagggugaagcgcggguaagaccgcguggaggcccgaacccacuuagguugaagacugaggggaugagcuguggguaggggugaaaggccaaucaaacuccgugauagcugguucuccccgaaaugcauuuaggugcagcgucgcauguuucuugccggagguagagcuacuggauggccgaugggccccacaggguuacugacgucagccaaacuccgaaugccgguaaguccaagagugcggcagugagacggcgggggauaagcuccgugcgucgagagggaaacagcccagaucgccggcuaaggccccuaagcgugugcuaaguggaaaaggaugugcagucgcgaagacaaccaggagguuggcuuagaagcagccacccuugaaagagugcguaauagcucacuggucaagugauugugcgccgauaauguagcggggcucaagcacaccgccgaagccgcggcagccaacguguuggcuggguaggggagcguccugcauccggugaagccgccgagugaucgagugguggagggugugggagugagaaugcaggcaugaguagcgauuaggcaagugagaaccuugcccgccgaaagaccaaggguuccugggccaggccaguccgcccagggugagucgggaccuaaggcgaggccgacaggcguagucgauggacaacggguugauauucccguacccguguaugugcguccaugaugaaucagcgguacuaaccauccaaaaccaccgugaccgcaccuuucgggguguggcguugguggggcugcaugggaccuucguugguaguagucaagcgauggggugacgcaggaagguagccguaccggucagugguaauaccgggguaagccuguagggagucagauagguaaauccgucuggcauauauccugagaggugaugcauagccgagugaggcgaauucggugauccuaugcugccgagaaaagccucuagcgaggacauacacggcccguaccccaaaccaacacagguggucagguagagaauacuaaggcguacgagugaacuaugguuaaggaacucggcaaaaugcccccguaacuucgggagaagggggacccacauggcguguaagccuuuacggcccaagcgugaguggguggcacaaaccagugagaagcgacuguuuacuaaaaacacagguccgugcgaagucgcaagacgauguauacggacugacgccugcccggugcuggaagguuaagaggacccguuaacucccuuugggggugaagcggagaauuuaagccccaguaaacggcggugguaacuauaaccauccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaacgacuucucaacugucucaaccauagacucggcgaaauugcacuacgaguaaagaugcucguuacgcgcggcaggacgaaaagaccccgggaccuucacuacaacuugguauuggugcucgauacgguuuguguaggauaggugggagacugugaagcucacacgccaguguggguggagucguuguugaaauaccacucugaucguauugggccucuaaccucggaccguauauccgguucagggacagugccugguggguaguuuaacuggggcgguugccuccuaaaauguaacggaggcgcccaaagguucccucaaccuggacggcaaucagguguugaguguaagugcacaagggagcuugacugcgagacggacaugucgagcagggacgaaagucgggacuagugauccggcaccucugaguggaaggggugucgcucaacggauaaaagguaccccggggauaacaggcugaucuuccccaagaguccauaucgacgggaugguuuggcaccucgaugucggcucgucgcauccuggggcuggagcaggucccaaggguugggcuguucgcccauuaaagcggcacgcgagcuggguuuagaacgucgugagacaguucggucucuauccgccgcgcgcgucagaagcuugaggaaaccugucccuaguacgagaggaccgggacggacgaaccucugguauaccaguugucccaccaggggcacggcuggauagccacguucggacaggauaaccgcugaaagcaucuaagcgggaaaccucuuccaagaccaggcuucucacccucuaggagggauaaggccccccgcagaccacgggauugauagaccagaccuggaagccuaguaauaggugcagggaacuggcacuaaccggccgaaaacuuac <<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<<......<<<<<<.[[.(((.>>>.....<<<<<<<..<<<)))..]].>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<.....>>..<<<<<<.....<<.....>>....>>>>>>...<<<....<<<<<<<<<<........((((((.....>>>>>>>>>>......<<<<..<.....<<<<<<<))))))>>>>>>><<<<<<.......<<<<<<.<<<<.<<<.....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>>>.....>...>>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..>>>......>>.>>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<<<<..>>>>.>>>>>..>>>>...<.<........>.>.<<<<<<....<<<.<<<<<<<<<<..<<<...<<<....>>>...>>>...<<....>>..<<<<.....>>>>....<<<<<<<....>>>>>>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<....<<<<<<<<.....<<<....<<<.<<<<.....<<<<<....>>>>>......>>>>.>>>..>>.>.....>>>>>>>>.......>>>>>>>.>>..<<<<<<<<<<......>>>>>>.>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..<<<<.......>>>>..>>>.........<<......>>...>>>>>....>>>>>>>>>.>>...........)))......>>>>>>.>>>...>>>>>>><<<<<<<<..>>>>>>>>....>>>>>><.<<<<<<<<<<......<<<<<<<<....>>>.>>>>>...>>>>>>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<.............<<<<<<<<......<<<<.<....<<<<<....<<.<<<<......>>>>.>>....>>>>>....>.>>>>.....>>>>>>>>.........<<...<<<<<...<<<<..<<<..<<<<..<<<<<...((((...>>>>>.<<..<<<<...<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>...>>>>...>>...<<<......>>>.....>>>>...>>>...>>>>........>>>>>..>>....>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<<...<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<...<<<<....<<<.....>>>....>>>>..>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.<<<....<<<<<.<<<<<<...>>>>>>..>>>>>....>>>.>>>>>>>>>..>>>>><<<<<.........>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>>>>>>>>.....>.((..<<<<<......))>>>>>..<<<<<<<<.<<<.<<......<<<<<<<<<<..<<<<<.<<<.<<<<<.<<.<<<<<<<<<<<<.............<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>.>...>>>>>>>>>>>>.>>...<<<.<<<<<<......>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.<<..>>>>..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<.<<<<...<<.......>>...>>>>.>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))))>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<...>>>>>....<<<<.<<<<.......>>>>.....<<<.<<<<.<<<....<<<<<....>>>>>...>>>..>>>>..>>>...>>>>....>>>>.. ((((......((((((((((.....(((..(((((((((((((......((((((.[[.[[[.))).....((((((...(((]]]..]].)))......))))))...)))....(((....)))(((((((......))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((.....))...(((((.....((.]...))....)))))....((([...(((((.(((..........[[[[[......))).)))))....(.((((..(.....(((.(((]]]]].))).))).(((((.......((((((.((((.(((...(.((((......)))))[[(...).(((.....]])))...)))...)))))))))))))))......)...))))]....(((((((...[.......)))))))....)..((((].[[[[))))...)))......)).))))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((..(((((((((..)))).)))))..)))).<.(.(........).).((((((..(.(((.((((((((((..(((...(((....)))...)))...((....))..((((.....))))....(((((((....)))))))....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......A))))))))..).))))))))).(.(((.....)))...)..))))))......).))).((((((....(((((....)))))(((((((((.([.((((((((.....(((....(((.((((....(..(((....)))...)....)))).)))..)).).....))))))))....).]))))))).))..((((((((((......)))))).))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.((([.(((.........)))..))).....(]..((......)).).)))))...)))))))))).))...........]]].)....))))))))))...)))))))((((((((..))))))))....))))))(.((((((((((......((((((((....))).)))))...))))))))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]]((((((((((.(..........(((((.((.......((((.(....(((((.(..((.((((......)))).)).)..)))))....).))))......)).))))..)......((...(((((...((((..(((..((((..(((((....{{....))))).((..(((....(((((((((((.((.....))))))))).....))))..[.)))...))...(((......))).....))))...)))...))))(..)....)))))..))..).)))))))))))))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((...((((....((((..)])))....))))..))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((....((((..((((((...))))))...))))....))...))))))))..)))))(.(((.........))).)........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....))[[..(((((.....>]])))))..((((((((.(((.((......((((((((((..(((((.(((.(((((.((.((((((((((((..(...........(((...((......((.(.(((....))).).))...)).............)))..)..)))))))))))).))...(((.((((((......)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....((.((((.((..]]]]..)))))).)).....)}......))))..))))))......(((((.(.(.((((...((.......))...)))).)...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..a.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..(((((...)))))....((((.((((.......)))).....(((.((((.(((....(((((....)))))...)))..))))..)))...))))....)))).. Mycobacterium smegmatis 50S ribosomal subunit with Erythromycin; 23S rRNA 8xz3 B 118 3.6 RF00001 39029461 0003735 0005840 246196 guuacggcgguccauagcggcagggaaacgcccggucccaucccgaacccggaagcuaagccugccagcgccgaugauacuacccauccggguggaaaaguaggacaccgccgaacac <<<.<<<<<<<.....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<.......<<<<<<....>>>>>>.......>>..>>>>>>>>>>.. (((.(((((((.....((((((((.....((((((...(.....)...))))..))....)))))).)).((.......((((((....)))))).......))..)))))))))).. Mycobacterium smegmatis 50S ribosomal subunit with Erythromycin; 5S rRNA 8y0u C1 3221 3.59 RF02543 URS000061F377_4932 38698775 0003735 0005840 4932 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagacaugguguuuuguauuucacgccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauagaggguguagaauaagugggagcuucggcgccagugaaauaccacuaccuuuauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>...{.....<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<.<<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]....}.............................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<<......................<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<....<<.<<<<<<<.....<<<....<<<..<.<<<<<..<<<<<<.....>>>>>>>>>>>.>..>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>..>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><<<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>.>>.....>>>>>><<<....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<<<<<.....>.>>>>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<.<<<<<<<<<<<....>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.....<<....<<<<<....>>>>.>...>>..>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>...>>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<<<<<<<<<..........<<.<........................>.>>.>>>>>>>.>>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>...............<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>..>>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<...<<<<<<<<<<<}}}.>>>>>..>>>>>>..>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((.((((.((((((((...({((((......)))))[[(...).(((....}]])))....))))))))...)))).))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.(((((.......................(((((((((((((((((((((((.......(((((((......((((.(....).)))).......))))))).....))))).))))))))))........(((....)))....)))))))).....))))).))))).[((((........))))((((((....((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))....((..((.((.......<)))).)).....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((....((.(((((((.....(((....(((...(((((....(((((.....)))))..)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........((((............))))....))....))...(((((........)))))]]((((..(((((((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((....)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(.(((..(((.((......((((.((((((..(((((.((((((((..(((((((((((((.(((..........((..(..(......)............)..)).))).))).))))))))))....((((.....((((..((((........))))...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......(..(.(.((((((...((.......))...))))))...))...)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).))).)....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(((.((..)..).)))..)))))...)))....)))).)))))).))))).. dormant ribosome with STM1; 25S rRNA 8y0u C4 121 3.59 RF00001 URS000055688D_4932 38698775 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). dormant ribosome with STM1; 5S rRNA 8y0u C3 158 3.59 RF00002 URS00001BF64E_4932 38698775 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... dormant ribosome with STM1; 5.8S rRNA 8y0u C2 1771 3.59 RF01960,RF02542,RF01959,RF00177 URS00005F2C2D_4932 38698775 0003735 0005840 4932 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugagcuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauu ...<<<<<.{.[[[[>>>>><<<<.<<<<<<...<.<...<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<..<<..<<....<<<..................<<....<<.<<<.....>>>.>>.....>>.........<<<<<..<<....>>..>>>>><...<<<<<<......(((((((.<<......>>..............>>>>>>.....>...<<<<..<<.......>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>..>>>..>....>.>.....<<<<<<<<<<<<<....>>>>>>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>>.........<<<[[.....<.<<...<<<.<<....<<<<<<.<<<<<...........>.>>>>.>>>>>>.....<<<<<....................>>>>>....<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........<<<..<<<<<<<<.....))))))).>>>>>>>>.>>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..]]>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..]]]].}<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<.<<......>>...<<<......>>>....>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>......<....<<<<<<..........>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<.<<<................>>>.>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>........ ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((.....(..........)....)){))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[[.[[[.(((....))).....(......).)))))).)...).(.((((.(...........))))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.(((......)))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(((((((.(.(((....))).).)))).)))......(((.(...........)).)).........((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((................))).)))))).....(((((....................)))))....(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(......((.(((.....]].]]]].))).)).....).....))...(((..((.((...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)).))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((.......(((....))).....)))...]]].].((((.((((..(..((..(((((..(((.((((((......((........))..........((((..(....(((((.....(..((.(((........))).))....).)))))....(.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((.(.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..).)))....))).))).....).))))......)..))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....((((((((.......))))))))......))...)..))))))).)...(.(..((.(..((((.((..(.((((((((.(((..(.((..(...((((((..(((................)))..))))))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>....... dormant ribosome with STM1; 18S rRNA 8y0w L5 3666 3.4 RF02543 URS000075EC78_9606 38698775 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcggcccggcggaucuuucccgcgcgggggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucgggggcccccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcgcucuccccccucccggcgcgccggggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccgggggaggccacgcgcgcgucccccgaagagggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcagacccgacgcccgccacgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagcggcggccggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcugggucggucgcggccggcgccuagcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacaugagugaucguuuuuucacugacccggugaggcgggggggcgagccccgaggggcucucgcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccggucccccgccgggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..[[[..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>>..<<<<<<<<<<...<<<<<<<<........<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>...>>>>>>>>..>>>>>>>>>>.......<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<.<....<<<<<<<<.<<<.....<<<<<<<<<<<..<<<<<<<...<<..<.....<<<<.<<<..<<<....>>>>>>>>>>.>..>>..>>>>...>>>>>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<<<<<<<<<<<<<<<<<...<<..<<<.<<.<<<<......<<<<<<<<..>>>>>>>>.......>>>>.>>>>>........>>>>>>..>>>>>>>>>>>....................<<<<<<.<<<<<<..............>>>>>>.<<<<<<.<<<<.<<<<<<<<<<<.<<<<..<<<<..<...........>...>>>>..>>>>.>.>>>>>>>.>>>...>>>>..>>>>.>>..<<<<<<<<<<.....>>>>>>>>.>>....>>>>>>.....>>>.>>>>>....>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<......>>>>>>>..<<<<<...<<<..<<<..((((.{.[[>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<......................<<<.<<<<<<<<<...<<<....<<<..<.<<<<.<..<.............>.>>>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.........>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<..........]].}.))))...........................>>>>>>>>>....>>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<<....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<.<.<...>.>.>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<..<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..{{{..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<...<..........>........>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>...>>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<<.<<<<<<<<..............>>>>>>>>...<<<<<.....<<<<.....................................<<<<<<<<<<<.....>>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))]......((((((..(((..>>>>>>.)))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]].....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<}}}.>>>>>..>>.>>...>>>>...>>>><<<<....<<<<<...........>>>>>....>>>>.>>>...>.>>>>>>.....<<<<<<<.<<..<<<<....<<<........<<<<<.<<<<....>>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>..............>>>>..>>>>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<.<..<<<<<......>>>>>..>>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((...((((((((((.....)))))).)))).....)))....((((((((((....((.((((...(....((((((((..({((((......)))))....[[(...).(((....}]])))...).))))))))..))))..))..))))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((..(...((((((((.(((.....(((((((((((..(((((((...((..(......(((.((....(.(..).)..)))))..)..))..))))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((.(..((((......(.(((((.().))))).).......))))..))))........))))))..)))))))))))...........[........((((((.((((((.....(.....)..)))))).((((((.((((.(((((((((((.((((..((((.(..............).))))..)))).).))))))).)))...))))..)))).))..((((((((((.....)))))))).))..[.)))))).....))).)))))...).)))...)))))))).<((((........))))((((((....(((((((((((((..(((..(((((........))))..)..)))...((....))...(((((((......)))))))..(((((...(((..(((..[[.....[[)))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((......................(((.((((((((....(((....(((..(.((((.(..(.............).))))).)..)))..)).)....))))))...(((((((((.(......))))))))))....))))))))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((..........]].....]]]..(.....)......]..........)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...((....(((....)))..........((.(((((...(....)..)))))))......))....))...(((((........)))))]]((((....(((((...((.((((....)))).))..((((....)))...(...((((((...(((((((((((((((((((((((..{{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....(((((((.......))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((...(([...)...])........)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..(((((([(]..((.....((((....)))).....)).)))))..)))))(.(((.........))).).(.)....((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.(.......((((.((((((..(((((.(((((((((.(((((((................)))))))...(((((.....((((.....((............))................((((((((((.......))))))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a..)..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}}.)))))..)).))...))))...)))).((((...((((.....}.......))))...))))..)))...).)))))).....((((((..((..((((.(..(((........(((((.((((.(.))))).))))).......)))...(((..(((.....((((.(((((((......)))))))))))....)))..)))...........)..))))..)).))))))(((((.(..(.......)..)....((.(((((((.((.....((((.(..(((((......)))))..)))))....))....)))).))).))..))))).. dormant ribosome with eIF5A, eEF2 and SERBP1; 28S rRNA 8y0w L7 120 3.4 RF00001 URS00000F9D45_9606 38698775 0003735 0005840 9606 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. dormant ribosome with eIF5A, eEF2 and SERBP1; 5S rRNA 8y0w L8 156 3.4 RF00002,RF02540 URS0000005270_9606 38698775 0003735 0005840 9606 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<.<<.....>>>.....(.<<<......>>.............>>>..)...>>>....<<....>><<<<<<<<<.....>>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))((((((((.......)))))))).................... dormant ribosome with eIF5A, eEF2 and SERBP1; 5.8S rRNA 8y0w S2 1735 3.4 RF01960,RF02542,RF01959,RF00177 URS00005A14E2_9606 38698775 0003735 0005840 9606 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucgcuccucucccacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgccccccguggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcgggcguccccgcccucucggccggggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggcccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggucggcccacggcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<....<<....<<<<<..................<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<........>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<<......>>>>>>>>.>>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<<..>>>.>...>>>>>>.........<<<....<<<.....>>>..>>>..>...>>.>.....<<.....<<..<<....>>..>>.......>>......<<..<...........>..>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<.......................<<.<.............>>>...<<<<<<.<.......<<...<.......>.<<<<..>>>>...>>......>.>>>..>>>........<.<<.<<<.<<<...............>>>.>>>.>>.>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<......<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<.......>>>>.>>>>.....>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.......>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<...<.<<<<<..........>>>>>>....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<.<<<<<<.<<<..<<<<.<<...<<<<<...<<.....................>>.....>>>>>...>>.>>>>..>>>.>>>>>>.>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..((....(((((...((.............((.....((.(((.....))).))......))......))..(((...((((........))))...))).((..(((((...(......)..)))))......)).(.((((.((((......))))))))))).)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).).....(.(((.(((.(((....))).).)).).).))......((..(...........)..)).........((((([[....(.((((.....((..]])).......))))))))))..)))))).)))..[......(.([[...(.(.((...(((..(.......................((.(.............)))...((((((.(.......((..((.......)).(((..)))....))......).)))..)))........(..(.(.(..(.................)..).).)..)....)....(((.(((..(...((((..((..((((((((...((........))......))))))))..)).......((....))...))))..)..)))..))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.((((......)))))))))).)..)))...((..]]))...))...].))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((...(...((((..((((((((((((.......)))).)))).....))))..))))..).....(((((.....)))))........)))....))).))).....).))))).....).)))))...)).)))).))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(.(..(((((.(((..(.((.((...((.((....(...(............)....)......)).))...)).)).)..))).))))).).)..)).))))...).))...)..)..(((((((((....)))))))))}........ dormant ribosome with eIF5A, eEF2 and SERBP1; 18S rRNA 8y0x L5 3658 3.3 RF02543 URS000075EC78_9606 38698775 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcggcccggcggaucuuucccgcgcgggggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucgggggcccccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcgcucuccccccucccggcgcgccggggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccgggggaggccacgcgcgcgucccccgaagagggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcagacccgacgcccgccacgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagcggcggccggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcugggucggucgcggccggcgccuagcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacaugagugaucguuuuuucacugacccggugaggcgggggggcgagccccgaggggcucucgcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccggucccccgccgggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..[[[..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>>..<<<<<<<<<<...<<<<<<<<........<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>...>>>>>>>>..>>>>>>>>>>.......<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<<<..<<<<<<<...<<..<<....<<<<.<<<..<<<....>>>>>>>>>>>>..>>..>>>>...>>>>>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<<<<<<<<<<<<<<<<<...<<..<<<.<<.<<<<......<<<<<<<<..>>>>>>>>.......>>>>.>>>>>........>>>>>>..>>>>>>>>>>>....................<<<<<<.<<<<<<<...<.....>..>>>>>>>.<<<<<<.<<<<.<<<<<<<<<<<.<<<<<.<<<<..<...........>...>>>>.>>>>>.>.>>>>>>>.>>>...>>>>..>>>>.>>..<<<<<<<<<<.....>>>>>>>>.>>....>>>>>>.....>>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<......>>>>>>>..<<<<<...<<<..<<<..[[[..((((>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<......................<<<.<<<<<<<<<...<<<....<<<..<.<<<..<..................>.>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.........>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<..........))))..]]]...<....>..................>>>>>>>>>....>>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<<....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<.<.<....>>.>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<..<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..{{{..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<...<..........>........>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<.<.....<<<<....>>>>.....>....>>>..>>>>><<<<.........>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>...>>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<<.<<<<<<<<..............>>>>>>>>...<<<<<.....<<<<........<........>...................<<<<<<<<<<.......>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))]......((((((..(((..>>>>>>.)))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]].....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<}}}.>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.....<<<<<<<.<<..<<<<....<<<........<<<<<.<<<<....>>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>..............>>>>..>>>>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<.<..<<<<<......>>>>>..>>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((...((((((((((.....)))))).)))).....)))....((((((((((...((((((((...(....((((((((..({((((......)))))....[[(...).(((....}]])))...).))))))))..))))))))..))))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((..(...((((((((.(((.....(((((((((((..(((((((...((..((.....(((.((....(.(..).)..))))).))..))..))))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((.(..((((......(.((((((())))))).).......))))..))))........))))))..)))))))))))...........[........((((((.((((((.....(.....)..)))))).((((((.((((.(((((((((((.((((..(((..(..............)..)))..)))).).))))))).)))...))))..)))).))..((((((((((.....)))))))).))..[.)))))).....))).)))))...).)))...)))))))).<((((........))))((((((....(((((((((((((..(((..(((((........))))..)..)))...((....))...(((((((......)))))))..(((((...(((..(((..[......[[)))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((......................(((.((((((((....(((....(((..(.(((..(..(.............).).))).)..)))..)).)....))))))...(((((((((.(......))))))))))....))))))))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((..........]]......]]..(.....)......]..........)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...((....(((....)))..........((.((((....(....)...))))))......))....))...(((((........)))))]]((((....(((((...((.((((....)))).))..((((....)))...(...((((((...(((((((((((((((((((((((..{{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....(((((((.......))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((...(([...)...])........)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..(((((((.....((((....)))).....)...))))..)))))(.((.........)).).(.)....((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.(.......((((.((((((..(((((.(((((((((.(((((((................)))))))...(((((.....((((.....((............))................((((((((((.......))))))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a..)..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}}.)))))..)).))...))))...)))).((((...((((.....}.......))))...))))..)))...).)))))).....((((((..((..((((.(..(((........(((((.((((.(.))))).))))).......)))...(((..(((.....((((.(((((((......)))))))))))....)))..)))...........)..))))..)).))))))(((((.(..(.......)..)....((.(((((((.((.....((((.(..(((((......)))))..)))))....))....)))).))).))..))))).. Dormant ribosome with SERBP1; 28S rRNA 8y0x L7 120 3.3 RF00001 URS00000F9D45_9606 38698775 0003735 0005840 9606 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. Dormant ribosome with SERBP1; 5S rRNA 8y0x L8 156 3.3 RF00002,RF02540 URS0000005270_9606 38698775 0003735 0005840 9606 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<<<<....>>>>.....<.<<<......>>.............>>>..>...>>>....<<....>><<<<<<<<<.....>>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))((((((((.......)))))))).................... Dormant ribosome with SERBP1; 5.8S rRNA 8y0x S2 1739 3.3 RF01960,RF02542,RF01959,RF00177 URS00005A14E2_9606 38698775 0003735 0005840 9606 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucgcuccucucccacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgccccccguggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcgggcguccccgcccucucggccggggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaauggaauagaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggucggcccacggcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<....<<....<<<<<..................<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<........>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<<......>>>>>>>>.>>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<<..>>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....<<.....<<..<<....>>..>>.......>>......<<..<...........>..>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<.......................<<.<.............>>>...<<<<<<.<.......<<...<.......>.<<<<.......>>>>...>>......>.>>>..>>>.......<.<<.<<<.<<<...............>>>.>>>.>>.>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<.......>>>>.>>>>.....>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>............<<<<<..........>>>>>...........>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<....<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<...<<.....................>>.....>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>.....>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..((....(((((...((.............((.....((.(((.....))).))......))......)).((((...((((........))))...))))((..(((((...(......)..)))))......)).(.((((.((((......))))))))))).)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).).....(.(((.(((.(((....))).)).).).).))......((..(...........)..)).........((((([[....(.((((.....((..]])).......))))))))))..)))))).)))..[......(.([[...(.(.((...(((..(.......................((.(.............)))...((((((.(.......((..((.......)).((.(......)))....))......).)))..))).......(.((.(.(..((...............))..).).)).)....)....(((.((...(...((((..((..((((((((...((........))......))))))))..)).......((....))...))))..)...))..))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.((((......)))))))))).)..)))...((..]]))...))...].))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))........(.(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((...(...((((..((((((((((((.......)))).)))).....))))..))))..).....(((((.....)))))........)))....))).))).....).))))).....).))))))..)).)))).))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....(((((.((.......)).)))))......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..((((.((...(((((....(...(............)....)......)))))...)).))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}........ Dormant ribosome with SERBP1; 18S rRNA 8y0x E 80 3.3 RF00005,RF01852 URS00021ED8EE_9606 38698775 0030533 0006412 9606 guagucguggccgagugguuaaggcgauggaaauccauuggggucuccccgcgcagguucgaauccugccgacuacgcca <<<<<<<..<<<..........>>><<<<......>>>><<<<...>>>>..<<<<<.......>>>>>>>>>>>>.... (((((((..(((.(...[.)..))).((((....)))).(.((....)))..(((((..]....)))))))))))).... Dormant ribosome with SERBP1; EtRNA 8y36 A 2885 2.65 RF02541 38992047 0003735 0005840 1280 uuaaguuauuaagggcgcacgguggaugccuuggcacuagaagccgaugaaggacguuacuaacgacgauaugcuuuggggagcuguaaguaagcuuugauccagagauuuccgaauggggaaacccagcaugaguuaugucauguuaucgauaugugaauacauagcauaucagaaggcacacccggagaacugaaacaucuuaguacccggaggaagagaaagaaaauucgauucccuuaguagcggcgagcgaaaugggaagagcccaaaccaacaagcuugcuuguugggguuguaggacacucuagaguuacaaaggacgacauuagacgaaucaucuggaaagaugaaucaaagaagguaauaauccuguagucgaaaauguugucucucuugaguggauccugaguacgacggagcacgugaaauuccgucggaaucugggaggaccaucuccuaaggcuaaauacucucuagugaccgauagugaaccaguaccgugagggaaaggugaaaagcaccccggaaggggagugaaauagaaccugaaaccgugugcuuacaaguagucagagcccguuaaugggugauggcgugccuuuuguagaaugaaccggcgaguuacgauuugaugcaagguuaagcaguaaauguggagccguagcgaaagcgagucugaauagggcguuuaguauuuggucguagacccgaaaccaggugaucuacccuuggucagguugaagaauggaggaccgaaccgacuuacgungaaaagugagcggaugaacugaggguagcggagaaauuccaaucgaaccuggagauagcugguucucuccgaaauagcuuuagggcuagccucaagugaugauuauuggagguagagcacuguuuggacgagggggguuaccgaauucagacaaacuccgaaugccaauuaauuuaacuugggagucagaacaugggugauaagguccguguucgaaagggaaacagcccagaccaccagcuaaggucccaaaauauauguuaaguggaaaaggauguggcguugcccagacaacuaggauguuggcuuagaagcagccaucauuuaaagagugcguaauagcucacuagucgagugacacugcgccgaaaauguaccggggcuaaacauauuaccgaagcuguggauuguccuuuggacaaugguaggagagcguucuaagggcguugaagcaugaucguaaggacauguggagcgcuuagaagugagaaugccggugugaguagcgaaagacgggugagaaucccguccaccgauugacuaagguuuccagaggaaggcucguccgcucuggguuagucggguccuaagcugaggccgacaggcguaggcgauggauaacagguugauauuccuguaccaccuauaaucguuuuaaucgauggggggacgcaguaggauaggcgaagcgugcgauuggauugcacgucuaagcaguaaggcugaguauuagaaauccgguacucguuaaggcugagcugugauggggagaagacauugugucuucgagucguugauuucacacugccgagaaaagccucuagauagaaaauaggugcccguaccgcaaaccgacacagguagucaagaugagaauucuaaggugagcgagcgaacucucguuaaggaacucggcaaaaugaccccguaacuucgggagaaggggugcucuuuaggguuaacgcccagaagagccgcagugaauaggcccaagcgacuguuuaucaaaaacacaggucucugcuaaaccguaaggugauguauaggggcugacgccugcccggugcuggaagguuaagaggagugguuagcuucugcgaagcuacgaaucgaagccccaguaaacggcggccguauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacccgcacgaaaggcguaacgauuugggcacugucucaacgagagacucggugaaaucauaguaccugugaagaugcagguuacccgcgacaggacggaaagaccccguggagcuuuacuguagccugauauugaaauucggcacagcuuguacaggauagguaggagccuuugaaacgugagcgcuagcuuacguggaggcgcuggugggauacuacccuagcuguguuggcuuucuaacccgcaccacuuaucguggugggagacagugucaggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcucaaagguucccucagaaugguuggaaaucauucauagaguguaaaggcauaagggagcuugacugcgagaccuacaagucgagcagggucgaaagacggacuuagugauccggugguuccgcauggaagggccaucgcucaacggauaaaagcuaccccgnggauaacaggcuuaucucccccaagaguucacaucgacggggagguuuggcaccucgnugucggcucaucgcauccuggggcuguagucggucccaaggguugggcuguucgcccauuaaagcgguacgcgagcuggguucagaacgucgugagacaguucggucccuauccgucgugggcguaggaaauuugagaggagcuguccuuaguacgagaggaccgggauggacauaccucugguguaccaguugucgugccaacggcauagcuggguagcuauguguggacgggauaagugcugaaagcaucuaagcaugaagccccccucaagaugagauuucccaacuucgguuauaagaucccucaaagaugaugagguuaauagguucgagguggaagcauggugacauguggagcugacgaauacuaaucgaucgaagacuuaau <<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<<<<<<<<.........>>>>>>>.>>.>>....<<<<<......<<....>>.......>>>>.>...................<<<<<......<<.....>>.....>>>>>..(((....<<<<<<<<<..>>>>>>>>>......<<<<<<<<...<<<.......<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>..>>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<....>>>>..................>>>>>>>>>>>.......<<<<..<<<<......>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<.<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>.>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<..........>.>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<...<<<<<<<<<.....<<<...<<<<<<<<...<<.......>>...>>>>>>>>..>>.>.....>>>>.>>>>>..>>>>>>>.>>..<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<.<<<<...........<..<<.....................>>.......................>.......>>>>.>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<...>>>>>>>....>>>>>>..<<<<<<<.<<......<<<<<.<<....>>.>>>>>...>>.>>>>>>>........>>>>>><......<<....<<<<<<.......>>>>>><<<<....<<<<<.<<<..<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<............<...<<<<....<<<<..<<<..<<<<<.<.......{.{.......>.............<<<....<<<..........>>>.........>>>...................................>>>>>...>>>...>>>>.........>>>>..>.......>>>>>>>>>>>.>>>.....<<......>>>>>>>.<<<<....>.>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<....<....>.....>>>>><<<<<<<.<<<<....>>>>.>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<..<<....>>...>>>>>...>>...>>>>>>>>..>>>>><<<<<.....>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<<.<<<<.<<<....................<<<<..<<.........<.<<<<....>>>>.>......>>............>>>>...........>>>.>>>>....<<.<<<<<<.....>>>>>>>>.....>>>>>>>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.}.}>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<......>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>. ((((((......((((((((((.....(((..((((((((.((((......((((((..[[.[[.))).....((((((...(((]].]]..)))......))))))...)))....(((....)))(((((((......))))))).(((((((.(.........).))))).)).))....(((((......(...[..).......)))).).........(.....)....((((......((.]...)).....))))...((((...((((((((....))))))))......(((((((......(.......((..((.....(((...(((((......)))))[[(...).(((.....]])))...))).......))..)))......)))..)))))....((((((....[........))))))......(((((].[[[[)))))..)))......))..)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((..((((..[...))))..)))).{.(.(........).).((((((....(((((((.(((((..(((...(((.....)))...)))...((....))..((((.....)))).....))))).)))))))..((.(...((((((.....((((((((((.((((..........){)))...(((.(((((.......A))))))))..).))))))))).(.(((....[)))...).]))))))......).))..((((((....(.(((....))).)(((((((((...(((((((((.....(((...((((((((.................))))))))..)).).....)))).)))))..))))))).))..((((((((((......))))))))))....(((......)))...((.(.(((...((([[[...(.((((((.....(.....((..((((.((.((..........(.(..(...................)........................))......)).)).)))).))...........]]].)...))))))))))...)))).)).(((((.....))))).....))))))(.(((((((.((......(((((.((....))])))))...)).)))))))..).....))))))(......((....((((((.......))))))((((....(((...((...((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]]((((((.................((((....(((((.(((..(((((...........<..........(.....(.....((.....((..........))..........)).....)......).......................)))))...)))..)))))(..).....))))...........))))))))))..)).....((......))..))).(((.......)))..))))..((((....((((((((.((..(....(.......(((((....(.[..).....)))))(((((((.(((......))).)))))))(...).......(((((((((.}.((.........))...(((((((.....(((....))).......))))))).]((((.(((..(((((((..(((...((...(((((..((....))...)))))...))...))))))))..)))))(((((.....)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).[..(((((.....}].)))))..((((((((.(((.((......((((.((((((..(((((.(((((((((.((((.(((...(.(...(................(((...........((......))........)))..................)..).)...))).)))).....(.((((((.....)))))))......)))))))))..)))))..(((......[)))((((((..........]))))))([.(....((((((.(.(((.(.........).)))...).((][.[[[))....))))))....((((..(((...{..)))..)))).(((....))).).]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..a.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.>..))))))..)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.(......).....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))...))))))). cryo-EM structure of Staphylococcus aureus(ATCC 29213) 50S ribosome in complex with MCX-190.; 23S ribosomal RNA 8y36 B 115 2.65 RF00001 38992047 0003735 0005840 1280 ucuggugacuauagcaaggaggucacaccuguucccaugccgaacacagaaguuaagcuccuuagcgucgaugguagucgaacuuacguuccgcuagaguagaacguugccaggc <<<<<<<<<....<<<<<<<<.....<<<<<<.............>>>>..>>....>>>>>>.>>.<<......<<<.<<<<....>>>>.>>>......>>..>>>>>>>>>. ..((((.((....((((((((.......((((...(.....)...))))........)))))).)).((.......((.((((....)))).)).......))..)).))))... cryo-EM structure of Staphylococcus aureus(ATCC 29213) 50S ribosome in complex with MCX-190.; 5S ribosomal RNA 8y37 A 2884 2.53 RF02541 38992047 0003735 0005840 1280 uuaaguuauuaagggcgcacgguggaugccuuggcacuagaagccgaugaaggacguuacuaacgacgauaugcuuuggggagcuguaaguaagcuuugauccagagauuuccgaauggggaaacccagcaugaguuaugucauguuaucgauaugugaauacauagcauaucagaaggcacacccggagaacugaaacaucuuaguacccggaggaagagaaagaaaauucgauucccuuaguagcggcgagcgaaaugggaagagcccaaaccaacaagcuugcuuguugggguuguaggacacucuagaguuacaaaggacgacauuagacgaaucaucuggaaagaugaaucaaagaagguaauaauccuguagucgaaaauguugucucucuugaguggauccugaguacgacggagcacgugaaauuccgucggaaucugggaggaccaucuccuaaggcuaaauacucucuagugaccgauagugaaccaguaccgugagggaaaggugaaaagcaccccggaaggggagugaaauagaaccugaaaccgugugcuuacaaguagucagagcccguuaaugggugauggcgugccuuuuguagaaugaaccggcgaguuacgauuugaugcaagguuaagcaguaaauguggagccguagcgaaagcgagucugaauagggcguuuaguauuuggucguagacccgaaaccaggugaucuacccuuggucagguugaagaauggaggaccgaaccgacuuacgungaaaagugagcggaugaacugaggguagcggagaaauuccaaucgaaccuggagauagcugguucucuccgaaauagcuuuagggcuagccucaagugaugauuauuggagguagagcacuguuuggacgaggggccgguuaccgaauucagacaaacuccgaaugccaauuaauuuaacuugggagucagaacaugggugauaagguccguguucgaaagggaaacagcccagaccaccagcuaaggucccaaaauauauguuaaguggaaaaggauguggcguugcccagacaacuaggauguuggcuuagaagcagccaucauuuaaagagugcguaauagcucacuagucgagugacacugcgccgaaaauguaccggggcuaaacauauuaccgaagcuguggauuguccuuuggacaaugguaggagagcguucuaagggcguugaagcaugaucguaaggacauguggagcgcuuagaagugagaaugccggugugaguagcgaaagacgggugagaaucccguccaccgauugacuaagguuuccagaggaaggcucguccgcucuggguuagucggguccuaagcugaggccgacaggcguaggcgauggauaacagguugauauuccuguaccaccuauaaucguuuuaaucgauggggggacgcaguaggauaggcgaagcgugcgauuggauucacgucuaagcaguaaggcugaguauuaaauccgguacucguuaaggcugagcugugauggggagaagacauugugucuucgagucguugauuucacacugccgagaaaagccucuagauagaaaauaggugcccguaccgcaaaccgacacagguagucaagaugagaauucuaaggugagcgagcgaacucucguuaaggaacucggcaaaaugaccccguaacuucgggagaaggggugcucuuuaggguuaacgcccagaagagccgcagugaauaggcccaagcgacuguuuaucaaaaacacaggucucugcuaaaccguaaggugauguauaggggcugacgccugcccggugcuggaagguuaagaggagugguuagcuucugcgaagcuacgaaucgaagccccaguaaacggcggccguauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacccgcacgaaaggcguaacgauuugggcacugucucaacgagagacucggugaaaucauaguaccugugaagaugcagguuacccgcgacaggacggnaagaccccguggagcuuuacuguagccugauauugaaauucggcacagcuuguacaggauagguaggagccuuugaaacgugagcgcuagcuuacguggaggcgcuggugggauacuacccuagcuguguuggcuuucuaacccgcaccacuuaucguggugggagacagugucaggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcucaaagguucccucagaaugguuggaaaucauucauagaguguaaaggcauaagggagcuugacugcgagaccuacaagucgagcagggucgaaagacggacuuagugauccggugguuccgcauggaagggccaucgcucaacggauaaaagcuaccccgnggauaacaggcuuaucucccccaagaguucacaucgacggggagguuuggcaccucgnugucggcucaucgcauccuggggcuguagucggucccaaggguugggcuguucgcccauuaaagcgguacgcgagcuggguucagaacgucgugagacaguucggucccuauccgucgugggcguaggaaauuugagaggagcuguccuuaguacgagaggaccgggauggacauaccucugguguaccaguugucgugccaacggcauagcuggguagcuauguguggacgggauaagugcugaaagcaucuaagcaugaagccccccucaagaugagauuucccaacuucgguuauaagaucccucaaagaugaugagguuaauagguucgagguggaagcauggugacauguggagcugacgaauacuaaucgaucgaagacuuaau <<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<<<<<<<<.........>>>>>>>.>>.>>....<<<<<......<<....>>.......>>>>.>...................<<<<<......<<.....>>.....>>>>>..(((....<<..<<<<....>>>>..>>......<<<<<<<<...<<<.......<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>..>>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<....>>>>..................>>>>>>>>>>>.......<<<<..<<<<......>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<.<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>.>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<.............>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<...<<<<<<<<<.....<<<...<<<<<<<<....<.........>....>>>>>>>>..>>.>.....>>>>.>>>>>..>>>>>>>.>>..<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<.<<<<...........<..<<.....................>>.......................>.......>>>>.>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<...>>>>>>>....>>>>>>..<<<<<<<.<<......<<<<<.<<....>>.>>>>>...>>.>>>>>>>........>>>>>><......<<....<<<<<<.......>>>>>><<<<....<<<<<.<<<..<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<............<...<<<<....<<<<..<<...<<<<<.<.<.......{....>.>.............<<<.....<<<......>>>..........>>>...................................>>>>>....>>...>>>>.........>>>>..>.......>>>>>>>>>>>.>>>.....<<......>>>>>>>.<<<<....>.>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<<.<<<<....>>>>.>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<..<<....>>...>>>>>...>>...>>>>>>>>..>>>>><<<<<.....>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<..<<<<<<<<<.<<<<.<<<.....<<.............<.<<..<<.........<.<<<......>>>.>......>>............>>.>....>>.....>>>.>>>>....<<.<<<<<<.....>>>>>>>>.....>>>>>>>>>...>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.}..>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<......>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>. ((((((......((((((((((.....(((..((((((((.((((......((((((..[..[[.))).....((((((...(((]]..]..)))......))))))...)))....(((....)))(((((((......))))))).(((((((.(.........).))))).)).)).....((((......(...[..).......))))...........(.....)....((((......((.]...)).....))))...((((...(((.((((....)))).)))......(((((((......(........(..((.....(((...(((((......)))))[[(...).(((.....]])))...))).......))..).)......)))..)))))....((((((....[........))))))......(((((].[[[[)))))..)))......))..)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).......((((..((((..[...))))..)))).{.(.(........).).((((((..(.(((((((.(((((..(((...(((.....)))...)))...((....))..((((.....)))).....))))).)))))))..((.(...((((((.....((((((((((.((((...(..)...){)))...(((.(((((.......A))))))))..).))))))))).(.(((....[)))...).]))))))......).))).((((((....(.(((....))).)(.(((((((...(((((((((.....(((...((((((((...................))))))))..)).).....)))).)))))..)))))))..)..((((((((((......))))))))))....(((......)))...((.(.(((...((([[[...(.((((((.....(.....((..((.(.((.((...............(...(...........)...)................................)).)).).)).))...........]]].)...))))))))))...)))).)).(((((.....))))).....))))))(.(((((((.((......(((((.((....))])))))...)).)))))))..).....))))))(......((....((((((.......))))))((((...[(((...((...((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]]((((((.................((((....((((..((...(((((...........<.....................(......((........))...........)....................................)))))....))...))))(..).....))))...........))))))))))..)).....((......))..))).(((.......)))..))))]..(((....((((((((.((..(....(.......(((((....(.[..).....)))))(((((.(...............))))))(...).......(((((((((.}.(...........)...(((((((.....(((....))).......))))))).]((((..((..((.((((..(((...((...(((((.............)))))...))...)))))))...)))).(((((.....)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).))).)).....)..[..(((((.....}].)))))..((((((((.(((.((......((((.((((((..(((((.(((((((((.(..(.((((..(.....(............((..(((...........((......))........)))............))...).....)..))))..).).....(.((((((.....)))))))......)))))))))..)))))..(((......[)))((((((..........]))))))([.(....((((((.(.(((.(.........).)))...).((][.[[[))....))))))....((((..(((...{..)))..)))).(((....))).).]]].].....((((((((.(..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..a.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.>..))))))..)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.(......).....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))...))))))). Cryo-EM structure of Staphylococcus aureus (15B196) 50S ribosome in complex with MCX-190.; 23S ribosomal RNA 8y37 B 115 2.53 RF00001 38992047 0003735 0005840 1280 ucuggugacuauagcaaggaggucacaccuguucccaugccgaacacagaaguuaagcuccuuagcgucgaugguagucgaacuuacguuccgcuagaguagaacguugccaggc <<<<<<<<<....<<<<<<<<.....<<<<<<.............>>>>..>>....>>>>>>.>>.<<......<<<.<<<<....>>>>.>>>......>>..>>>>>>>>>. ..((((.((....((((((((.......((((...(.....)...))))........)))))).)).((.......((.((((....)))).)).......))..)).))))... Cryo-EM structure of Staphylococcus aureus (15B196) 50S ribosome in complex with MCX-190.; 5S ribosomal RNA 8y38 A 2885 2.58 RF02541 38992047 0003735 0005840 1280 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Cryo-EM structure of Staphylococcus aureus 70S ribosome (strain 15B196) in complex with MCX-190.; 23S ribosomal RNA 8y38 B 115 2.58 RF00001 38992047 0003735 0005840 1280 ucuggugacuauagcaaggaggucacaccuguucccaugccgaacacagaaguuaagcuccuuagcgucgaugguagucgaacuuacguuccgcuagaguagaacguugccaggc <<<<<<<<<....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<......<<<.<<<<....>>>>.>>>......>>..>>>>>>>>>. ..((((.((....((((((((.....((((((...(.....)...))))..))....)))))).)).((.......((.((((....)))).)).......))..)).))))... Cryo-EM structure of Staphylococcus aureus 70S ribosome (strain 15B196) in complex with MCX-190.; 5S ribosomal RNA 8y38 a 1479 2.58 RF01959,RF00177,RF02542,RF01960 URS0002311997_1280 38992047 0003735 0005840 1280 auggagaguuugauccuggcucaggaugaacgcuggcggcgugccuaauacaugcaagucgagcgaacggacugauguuagcggcggacgggugaguaacacguggauaaccuaccuauaagacugggauaacuucgggaaaccggagcuaauaccggauaauauuuugacgcaugguucaaaagugaaagacggcugucacuuauagauggauccgcgcugcauuagcuaguugguaagguaacggcuuaccaaggcaacgaugcauagccgaccugagagggugaucggccacacuggaacugagacacgguccagacuccuacgggaggcagcaguagggaaucuuccgcaaugggcgaaagccugacggagcaacgccgcgugagugaugaaggucuucggaucguaaaacucuguuauuagggaagaacauauguguaaguaacugugcacaucuugacgguaccuaaucagaaagccacggcuaacuacgugccagcagccgcgguaauacguagguggcaagcguuauccggaauuauugggcguaaagcgcgcguaggcgguuuuuuaagucugaugugaaagcccacggcucaaccguggagggucauuggaaacuggaaaacuugagugcagaagaggaaaguggaauuccauguguagcggugaaaugcgcagagauauggaggaacaccaguggcgaaggcgacuuucuggucuguaacugacgcugaugugcgaaagcguggggaucaaacaggauuagauacccugguaguccacgccguaaacgaugagugcuaaguguuaggggggccccuuagugcugcagcuaacgcauuaagcacuccgccuggggaguacgaccgcaagguugaaacucaaaggaauugacggggacccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaaaucuugacauccucuagagauagaggacagguggugcaugguugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuuaagcuuaguugccaucaugggcacucuaaguugacugccggugacaaaccggaggaagguggggaugacgucaaaucaucaugccccuuaugauuugggcuacacacgugcuacaauggacaauacaaagggcagcgaaaccgcgaggucaagcaaaucccauaaaguuguucucaguucggauuguagucugcaacucgacuacaugaagcuggaaucgcuaguaaucguagaucagcaugcuacggugaauacguucccgggucuuguacacaccgcccgucacaccacgagaguuuguaacacccgaagccgguggaguaaccuaggagcuagccgucgaaggugggacaaaugauuggggugaagucguaacaagguagccguaucggaaggugcggcuggaucaccuccuu .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<...<<......>>...>>>>>......<<........<<<<<<<..<<...<<<<<<<.<<<<.....<<<<<<....>>>>>>......>>>>......<<<.<.........>.>>>.......<..<.>..>..>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<<<<<<<.......<.<<<<<<<........>>>>>>>.>........>>>>>>...>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<<..<<<.<<<<<<<.<<<<<<<<<.......<<<<<<.....>>>>>>.....>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>..>>>>>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<.>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<.<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<.<<<<....>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<...<<<..<..>>>>....>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>.>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<..<<<<....<.<<<<..<<<..<<..>>.>>>.>>>>.>...>>>>..>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............. .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((...(........)...)))))......(((.......(((((((..((...(((((((.((((.....((((((....))))))......))))......(((.((.......)).))).......(..(.)..)..)))))))..))))))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..(.((((((...(.....(((((((........))))))).....)....))))))....).(((.([[[...(((((.....((.]]])).......)))))).)))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))...).)))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((....(...((((.........))))...).))))))......{...((((((..((((((((((((.))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.(((....((..((((((((((......((........))........(.(((((((..(...((.(((......))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(..))))...)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....))))))))..)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))...)....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((..((((....(.((((..(((..((())).))).)))).)...))))..))))))..))).))))..).))...)..)..((((((..(....)..))))))}............ Cryo-EM structure of Staphylococcus aureus 70S ribosome (strain 15B196) in complex with MCX-190.; 16S ribosomal RNA 8y39 A 2885 3.6 RF02541 38992047 0003735 0005840 1280 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((((((......((((((((((.....(((..((((((((.((((......((((((.[[[.[[.))).....((((((...(((]].]]].)))......))))))...)))....(((....)))(((((((......))))))).(((((((((.........))))))).)).))....(((((......(...[..).......)))).).........(.....)....((((......((.]...)).....))))...((((...((.(((((....)))).)))......(((((((......(........(..((.....(((...(((((......)))))[[(...).(((.....]])))...))).......))..).)......)))..)))))....((((((....[........))))))......(((((].[[[[)))))..)))......))..)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).......((((..((((..[...))))..)))).<.(.(........).).((((((..(.(((((((.(((((..(((...(((.....)))...)))...((....))..((((.....)))).....))))).)))))))..((.(...((((((.....((((((((((.((((...(..)...)<)))...(((.(((((.......A))))))))..).))))))))).(.(((....[)))...).]))))))......).))).((((((....(.(((....))).)(.(((((((...(((((((((.....(((...((((((((...................))))))))..)).).....)))).)))))..)))))))..)..((((((((((......))))))))))....(((......)))...((.(.(((...((([[[...(.((((((.....(.....((..((.(.((.((...............(...(...........)...)................................)).)).).)).))...........]]].)...))))))))))...)))).)).(((((.....))))).....))))))(.(((((((.((......(((((.((....))])))))...)).)))))))..).....))))))(......((....((((((.......))))))((((...[(((...((...((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]]((((((.................((((....((((..((...(((((.((((((....{{...))))))((...((((..(((...(((((......)))))........)))..))))....))....(.............)....)))))....))...))))(..).....))))...........))))))))))..)).....((......))..))).(((.......)))..))))]..(((....((((((((.((..(....(.......(((((....(.[..).....)))))(((((.(...............))))))(...).......(((((((((.>.(...........)...(((((((.....(((....))).......))))))).]((((..((..(((((((..(((...((...(((((..((....))...)))))...))...))))))))..))))...(((.....)))..........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).))).)).....)..[..(((((.....>].)))))..((((((((.(((.((......((((.((((((..(((((.(((((((((.(..(.((((..(.....(............((..(((...........((......))........)))............))...).....)..))))..).).....(.((((((.....)))))))......)))))))))..)))))..(((......[)))((((((..........]))))))([.(....((((((.(.(((.(.........).)))...).((][.[[[))....))))))....((((..(((...{..)))..)))).(((....))).).]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))..a.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))..)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.(......).....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))...))))))). cryo-EM structure of Staphylococcus aureus(ATCC 29213) 70S ribosome in complex with MCX-190.; 23S ribosomal RNA 8y39 B 115 3.6 RF00001 38992047 0003735 0005840 1280 ucuggugacuauagcaaggaggucacaccuguucccaugccgaacacagaaguuaagcuccuuagcgucgaugguagucgaacuuacguuccgcuagaguagaacguugccaggc <<<<<<<<<....<<<<<<<<.....<<<<<...............>>>..>>....>>>>>>.>>.<<......<<<.<<<<....>>>>.>>>......>>..>>>>>>>>>. ..((((.((....((((((((.....((((((...(.....)...))))..))....)))))).)).((.......((.((((....)))).)).......))..)).))))... cryo-EM structure of Staphylococcus aureus(ATCC 29213) 70S ribosome in complex with MCX-190.; 5S ribosomal RNA 8y39 a 1479 3.6 RF01959,RF00177,RF02542,RF01960 URS0002311997_1280 38992047 0003735 0005840 1280 auggagaguuugauccuggcucaggaugaacgcuggcggcgugccuaauacaugcaagucgagcgaacggacugauguuagcggcggacgggugaguaacacguggauaaccuaccuauaagacugggauaacuucgggaaaccggagcuaauaccggauaauauuuugacgcaugguucaaaagugaaagacggcugucacuuauagauggauccgcgcugcauuagcuaguugguaagguaacggcuuaccaaggcaacgaugcauagccgaccugagagggugaucggccacacuggaacugagacacgguccagacuccuacgggaggcagcaguagggaaucuuccgcaaugggcgaaagccugacggagcaacgccgcgugagugaugaaggucuucggaucguaaaacucuguuauuagggaagaacauauguguaaguaacugugcacaucuugacgguaccuaaucagaaagccacggcuaacuacgugccagcagccgcgguaauacguagguggcaagcguuauccggaauuauugggcguaaagcgcgcguaggcgguuuuuuaagucugaugugaaagcccacggcucaaccguggagggucauuggaaacuggaaaacuugagugcagaagaggaaaguggaauuccauguguagcggugaaaugcgcagagauauggaggaacaccaguggcgaaggcgacuuucuggucuguaacugacgcugaugugcgaaagcguggggaucaaacaggauuagauacccugguaguccacgccguaaacgaugagugcuaaguguuaggggggccccuuagugcugcagcuaacgcauuaagcacuccgccuggggaguacgaccgcaagguugaaacucaaaggaauugacggggacccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuuaccaaaucuugacauccucuagagauagaggacagguggugcaugguugucgucagcucgugucgugagauguuggguuaagucccgcaacgagcgcaacccuuaagcuuaguugccaucaugggcacucuaaguugacugccggugacaaaccggaggaagguggggaugacgucaaaucaucaugccccuuaugauuugggcuacacacgugcuacaauggacaauacaaagggcagcgaaaccgcgaggucaagcaaaucccauaaaguuguucucaguucggauuguagucugcaacucgacuacaugaagcuggaaucgcuaguaaucguagaucagcaugcuacggugaauacguucccgggucuuguacacaccgcccgucacaccacgagaguuuguaacacccgaagccgguggaguaaccuaggagcuagccgucgaaggugggacaaaugauuggggugaagucguaacaagguagccguaucggaaggugcggcuggaucaccuccuu .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<...<<......>>...>>>>>......<<........<<<<<<<..<<...<<<<<<<.<<<<.....<<<<<<....>>>>>>......>>>>......<<<.<.........>.>>>.......<..<.>..>..>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<<<<<<<.......<.<<<<<<<........>>>>>>>.>........>>>>>>...>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<<..<<<.<<<<<<<.<<<<<<<<<.......<<<<<<.....>>>>>>.....>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>..>>>>>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<.>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<.<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<.<<<<....>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<...<<<..<..>>>>....>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>.>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<..<<<<....<.<<<<..<<<..<<..>>.>>>.>>>>.>...>>>>..>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............. .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((...(........)...)))))......(((.......(((((((..((...(((((((.((((.....((((((....))))))......))))......(((.((.......)).))).......(..(.)..)..)))))))..))))))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..(.((((((...(.....(((((((........))))))).....)....))))))....).(((.([[[...(((((.....((.]]])).......)))))).)))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))...).)))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((....(...((((.........))))...).))))))......{...((((((..((((((((((((.))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.(((....((..((((((((((......((........))........(.(((((((..(...((.(((......))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(..))))...)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....))))))))..)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))...)....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((..((((....(.((((..(((..((())).))).)))).)...))))..))))))..))).))))..).))...)..)..((((((..(....)..))))))}............ cryo-EM structure of Staphylococcus aureus(ATCC 29213) 70S ribosome in complex with MCX-190.; 16S ribosomal RNA 8y6o A 13 3.38 38484052 9606 aaauauccuuuuc ............. ............. Cryo-EM Structure of the human minor pre-B complex (pre-precatalytic spliceosome) U11 and tri-snRNP part; pre-mRNA 8y6o J 109 3.38 RF00618 38484052 0030624,0030627 0000244,0000395 0005690 9606 naaccauccuuuucuugggguugcuacuguccaaugagcgcauagugagggcaguacugcuaaccgcaucaacuagagcgcuuuauuuuggugcaauuuuuggaaaaau ........................<<<<<<<......<<.....>>...>>>>>>>.........<<<<<<<.<<<<<..>>>>>..>>>>>>>............... .......................(((((.((.....((.....))..)).))))).........(((((((.(((((())))))..)))))))............... Cryo-EM Structure of the human minor pre-B complex (pre-precatalytic spliceosome) U11 and tri-snRNP part; U4atac snRNA 8y6o K 44 3.38 RF00619 38484052 0030622,0030627 0000244,0000395 0005691 9606 guuagcacuccccuugacaaggauggaagaggcccugggccuga .............................<<<<<...>>>>>.. .............................((((((.)))))).. Cryo-EM Structure of the human minor pre-B complex (pre-precatalytic spliceosome) U11 and tri-snRNP part; U6atac snRNA 8y6o P 124 3.38 RF00548 38484052 0030627 0000395 0005692 9606 aaaaagggcuucugucgugaguggcacacguagggcaacauugcucugcgugcggaaucgacaucaagagauuucggaagcauaauuuuuugguauuugggcagcuggugauucccggcgcccu .......<<<<.<<<<......>>>><<<<<<<<<<<<..>>>>>>>>>>>><<<<<<<..........>>>>>>>.>>>>.................<<<<.<<<<<.<<.>>>>>>>>>>>. .......(((((((((......))))(((((((.((((..)))).)))))))(((((((..........)))))))))))).................((((.(((((.(...)))))))))). Cryo-EM Structure of the human minor pre-B complex (pre-precatalytic spliceosome) U11 and tri-snRNP part; U11 snRNA 8y7e A 30 4.66 38484052 9606 cauauccuuaacucauugucccuuuuuuuu .............................. .............................. Cryo-EM Structure of the human minor pre-B complex (pre-precatalytic spliceosome) U12 snRNP part; pre-mRNA 8y7e H 50 4.66 RF00007 38484052 0045131 0000348 0005693 9606 augaguaaggaaaauaacgauucggggugacgcccgaagaauuuuugagc ....................<<<<<<......>>>>>>............ ....................((((((......))))))............ Cryo-EM Structure of the human minor pre-B complex (pre-precatalytic spliceosome) U12 snRNP part; U12 snRNA 8ydb C 60 3.4 39047725 2053611 uuuagaaggagaagucauuuaauaaggccacuguuaaaaaguguaccgccggauaggcgg .............................................<<<<<.....>>>>> .............................................(((((.....))))) Type I-FHNH Cascade-dsDNA intermediate complex; 60-nt crRNA 8ydb T 32 3.4 39047725 2053611 gtggccttattaaatgacttctccgctaatac ................................ ................................ Type I-FHNH Cascade-dsDNA intermediate complex; TS 8ydb N 11 3.4 39047725 2053611 gtattagcgga ........... ........... Type I-FHNH Cascade-dsDNA intermediate complex; NTS 8ydc A 57 2.89 RF03152 39103372 3.1.-.- 0004540 32630 cgagacaaccaggagucuauaaaauucccacugaugagacuggacgaaagacaugua ..<<<<..((((..>>>>.....................)))).............. ..[[[[..((((..]]]]............(....).[.)))).]............ Crystal structure of a hammerhead ribozyme with pseudoknot; ribozyme strand 8ydc B 14 2.89 39103372 32630 acaugucucuggga .............. .............. Crystal structure of a hammerhead ribozyme with pseudoknot; DNA/RNA (5'-R(*AP*CP*AP*UP*GP*UP*CP*U)-D(P*C)-R(P*UP*GP*GP*GP*A)-3') 8yeo C 60 3.44 39047725 2053611 uuuagaaggagaagucauuuaauaaggccacuguuaaaaaguguaccgccggauaggcgg .............................................<<<<<.....>>>>> .............................................(((((.....))))) Type I-FHNH Cascade-dsDNA R-loop complex; 60-nt crRNA 8yeo T 48 3.44 39047725 2053611 gccaagctttttaacagtggccttattaaatgacttctccgctaatac ................................................ ................................................ Type I-FHNH Cascade-dsDNA R-loop complex; TS 8yeo N 11 3.44 39047725 2053611 gtattagcgga ........... ........... Type I-FHNH Cascade-dsDNA R-loop complex; NTS 8yhd M 53 2.93 39143216 256318 guuaaaacucuucucaugcuggauucgaaauuaggugcgcuucgcguuuaagu ..................................................... ..................................................... Cryo-EM structure of CTR-bound type VII CRISPR-Cas complex at post-state I; RNA (53-MER) 8yhd N 35 2.93 39143216 256318 gaagcgcaccuaauuucgaauccagcaugagaagc ................................... ................................... Cryo-EM structure of CTR-bound type VII CRISPR-Cas complex at post-state I; RNA (35-MER) 8yhe M 46 3.07 39143216 256318 guuaaaacucuucucaugcuggauucgaaauuaggugcgcuucgcg .............................................. .............................................. Cryo-EM structure of CTR-bound type VII CRISPR-Cas complex at post-state II; RNA (46-MER) 8yhe N 30 3.07 39143216 256318 caccuaauuucgaauccagcaugagaagcu .............................. .............................. Cryo-EM structure of CTR-bound type VII CRISPR-Cas complex at post-state II; RNA (29-MER) 8yld 2 1771 3.9 RF01960,RF02542,RF01959,RF00177 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugagcuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauu ...<<<<<.{.[[[[>>>>><<<<.<<<<<<...<.<...<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<..<<..<<....<<<..................<<....<<..<<.....>>..>>.....>>.........<<<<<..<<....>>..>>>>><.<.<<<<<<......(((((((.<<<....>>>....<<......>>>>>>>>.>...>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>...<<....>>.....>>>>>>.........<<<....<<<.....>>>..>>>..>....>.>.....<<<<<<<<<.<<<....>>>.>>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>>.........<<<[[.....<.<<...<<<.<<....<<<<<<.<<<<..............>>>>.>>>>>>.....<<<<<....................>>>>>....<<<<<.<<.......<<...<.......>..<<<<...>>>>....>>......>>.>>..>>>.........<<...<<<<<<<<.....))))))).>>>>>>>>..>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.....<<<......>>>........>>>>>>..>>.......<<....>>...>>>>..>.>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..]]>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..]]]].}<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<.<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>.>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.......<.<<<<....>>>>..>.....>>.......>>>>>>>......<....<<<<<<..........>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<..<<<.<<<<....>>>>.>>>..>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>........ ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[[.[[[.(((....))).....(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....))..)..)))))).).....(.(((...((((.}...))).))))).)....).).....(((((((.(.(((....))).).)))).)))....(.(((..............).))......)..((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((.....(.....)....))).))))))......((((....................)))).....(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(....(.((.((......]].]]]]..)).)).)...).....))...((..(((.((...((((..((..((((((.(...((........)).......)))))))..)).......((....))...))))..)).)))...)..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..(((.((((.((..........)))))).)))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].].((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((.....((((((.(..(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(..(((((.....))))).....)..))))).)..))).))).......))))).....).)))))...)).)))).))).(...(((((((......((......(..(.((....)).)...)....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).)...(.(..((.(..((((.((....(((((((..(((..(.((..(...((((((....((.((((....)))).))....))))))...)..)).)..)))..)))))))...)).))))...).))...)..)..(((((((((....)))))))))>....... State 4a (S4a) of yeast 80S ribosome bound to 2 tRNAs and open eEF3 and eEF2 during translocation; 18S rRNA 8yld A 3193 3.9 RF02540,RF02541,RF02543 0003735 0005840 559292 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........................<<<<<<.....<<....>>......>>>>>.>...{.....<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<.<<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.((......<<<.....))>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]....}.............................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<.......<<<<<<<.<<<<<<<<<<<<<<<......<<<<<<<<....<.<<<<<<....>>>>>>>......>>>>>>>.>...>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>...>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<......<<<<<<<<..<<<<...<<<<<<<....>>>>>>>...>.>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>....<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<..<.<<<<....<.<...>.>..>>>>.>..>>>..>>.>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<........<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>....>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>.........<<<............>>>.....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<....>>>...<...<<<<<<...<<<<.<<<<<<<<<<<<<<<<<<..{{{..>>>>>>....<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>.....<<<<<<<<....>>>>>>>>>>>>.>.>>>>>>>.>>>>.........>>>>>>...>......>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<.....<..>......>>>>><<.<<<<<<<<<<<..>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<.....<<<....<<<<<....>>>>.>...>>>..>>>..>>>>>.<<<<<.......>>>>>.........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<...<<<.<<.<...........<<<......................>>>...>>>.>>>....>>>>>>>...<<<<<.....<<<<.................................<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<.<<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>..>>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<.<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<...<<<<<<<<<<.}}}..>>>>..>>>>>>..>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>.>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<..<.......>..>.....<<<<<<<<<.<<<....<<<<.<..<<<<<....>>>>>..>>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((.(((...))).)).))....)........((((((.((((((((.((((.(((((((...({((((......)))))[[(...).(((....}]])))....)))))))...)))).)))....)))))))))))...)....(((((((........))))))).....((.((..[[[[[[)).))..)))..................................((....))...............((((....))))..................................(((((.(((((.......((((((((.((((.(((((((((.......(((((((......((((.((..)).)))).......))))))).....))))).)))).)))).........(((....)))....))))))))...))))).))))).<((((........))))((((((..(.(.(.((.((((((..(((...((((.....))))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).)).).)..((.(...((((((......(((((((((.((((...((((((......))))))...)<)))...((...((.((........))))..))..).))))))))..(.((.......))...)..))))))......).))).((((((....(.(((....))).)((((((((((....((.(((((((.....(((....((...(.((((...(.(.....).).)))).)...))..)).).....)))))...((((..(((.(......))))..)))).....))))..)))))))).))..((((.((.((.....)).)).))))....(((......)))...(((((((...((([[[.....((((((......(..........(((.(((((((((......{.(((((.(((...(...........)...)))..........(......)....)))))....))))))))))))..........]]].)....)))))).)))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((.......(((.((((....)))))))....))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...((((((...((.....)).))))))....[[(((.((...((....(((....))).........(.................)....))....))...(((((........)))))]]((((.((((.(((...((((....)))...(.[[((((((...((((.(((((((((((((((((....{{...)))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....)).)..)))))))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((..)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].((..(((..((((((.(...((.....((((....)))).....)).)))))..))))).(.((.........)).).........((..........(((((.......)))))..)..).....))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..((..((......((((.((((((..(((((.((.(((((...(((((((...((.((.(..........(..(..(......)............)..)..))).))....)))))))....(((.(.....((((............................]]...((((((....))))))..))))..).))).....))))).))..)))))..(((......[)).)(((((...........].)))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))....((..((((....{..))))..).).((......)).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(..(((((...((.......))...)))))....)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))....))...)).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....(((((((((.}}...))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......(.((((.(((.......((.(........(((((((..).)))))).....))).......((((((...((.((.(..(((......)))..).)).)).))))))................))).)))).)..(((((.(..(.......)..)...(.(((((((((.((.....((((.(..((((((..))))))..)))))....))....)))).)))))).))))).. State 4a (S4a) of yeast 80S ribosome bound to 2 tRNAs and open eEF3 and eEF2 during translocation; 25S rRNA 8yld B 121 3.9 RF00001 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<<............>>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). State 4a (S4a) of yeast 80S ribosome bound to 2 tRNAs and open eEF3 and eEF2 during translocation; 5S rRNA 8yld C 158 3.9 RF00002 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<(.....>>............).>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... State 4a (S4a) of yeast 80S ribosome bound to 2 tRNAs and open eEF3 and eEF2 during translocation; 5.8S rRNA 8yld s 75 3.9 RF00005 URS00021ED942_559292 0030533 0006412 559292 agcgccgugacgcaguggaagcgcgcagggcucauaacccugauguccucggaucgaaaccgagcggcgcuacca <<<<<<<...<<<.......>>>..<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((...(((....[..)))..(((((.......))))).....(((((..]....)))))))))))).... State 4a (S4a) of yeast 80S ribosome bound to 2 tRNAs and open eEF3 and eEF2 during translocation; tRNA 8yld t 75 3.9 RF00005 URS00021ED942_559292 0030533 0006412 559292 agcgccgugacgcaguggaagcgcgcagggcucauaacccugauguccucggaucgaaaccgagcggcgcuacca <<<<<<<...<<<.......>>>..<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((...(((....[..)))..(((((.......))))).....(((((..]....)))))))))))).... State 4a (S4a) of yeast 80S ribosome bound to 2 tRNAs and open eEF3 and eEF2 during translocation; tRNA 8ylr 2 1771 3.9 RF01960,RF02542,RF01959,RF00177 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugagcuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauu ...<<<<<.{.[[[[>>>>><<<<.<<<<<<...<.<...<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<..<<..<<....<<<..................<<....<<.<<<.....>>>.>>.....>>.........<<<<<..<<....>>..>>>>><...<<<<<<......(((((((.<<<....>>>....<<......>>>>>>>>.....>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<<..>>>.>...>>>>>>.........<<<....<<<.....>>>..>>>..>....>.>.....<<<<<<<...<<<....>>>...>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>>.........<<<[[.....<.<<...<<<.<<....<<<<<<.<<<<..............>>>>.>>>>>>.....<<<<<....................>>>>>....<<<<<.<<.......<<...<.......>..<<<<...>>>>....>>......>>.>>..>>>.........<<<..<<<<<<<<.....))))))).>>>>>>>>.>>>.....>>....<<<<<<.<<...<<<<..<<<.<<<<<<.<...<<<......>>>......>.>>>>>>.>>>.......<<....>>...>>>>..>>.>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..]]>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..]]]].}<<....<.<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>.<.<<.<<<.....<<<<<<....<<<.<..<......>....<<<......>>>....>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.......>>>>>>....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>......<....<<<<<<..........>>>>>>....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>.....>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<..<<<.<<<<....>>>>.>>>..>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>........ ...((((..[.[[[..))))((.(.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..................((....((..((.....))..)).....)).........(((((..((....))..)))))(.(.((((((......[[[.[[[.(((....))).....(......).)))))).)...).(.((((.(.(((..).)).))))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.(((......)))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(((((((.(.(((....))).).)))).)))....(.(((.(...........)).))......)..((((([[....(.((((.....((..]])).......))))))))))..))))))).))..{......((({{...(.(.((...(((.((....((((((.(((................))).)))))).....(((((....................)))))....(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(....(.((.((......]].]]]]..)).)).)...).....))...((..(((..(...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)..)))...)..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.((..........))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].]((......(((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))....(.((......((((((.(..(((..((.(....).)..(.((......)))...)..)))....(((.(.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..).))).)..))).)))........)))......).)))))...)).)))).))).(...(((((((......((.....((..(.((....)).)..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....((((((((.......))))))))......))...)))))......))..(.(..((.(..((((.((....((((((((.(((..(.((..(...((((((...(((.((((....)))).)))...))))))...)..)).)..))).))))))))...)).))))...).))...)..)..(((((((((....)))))))))>....... State 6 (S6) of yeast 80S ribosome bound to 2 tRNAs and eEF2 and eEF3 during tranlocation; 18S rRNA 8ylr A 3192 3.9 RF02540,RF02541,RF02543 0003735 0005840 559292 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........................<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<........<<.<<<<<<...>>>>>>.>>........>....<<<<<<.<<<<<<<<<<<<<<<<<<<<<.....<<<<......>>>>.((......<<<.....))>>>....>>>>>>>>>..>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<.......<<<<<<<.<<<<<<<<<<<<<<<......<<<<<<<<......<<<<<<....>>>>>>.......>>>>>>>.>...>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>...>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<...<<<<<<<....>>>>>>>...>.>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<..<.<<<<....<.<...>.>..>>>>.>..>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><<<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>.>>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>...........<<..........>>.......>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<<....<<<....>>>...<...<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>>....<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>.....<<<<<<<<....>>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>...>.....>>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<.....<..>......>>>>><<.<<<<<<<<<<<..>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<.....<<<.....<<<<....>>>>.....>>>..>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<..<<<.<<..............<<.....................>>.....>>.>>>...>>>>>>>>...<<<<<.....<<<<.................................<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>..>>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<....<<<<<<<<<.}}}..>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<..<.......>..>.....<<<<<<<<<.<<<....<<<<....<<<<<....>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((..(((.((((((((...({((((......)))))[[(...).(((....}]])))....))))))))...)))..))....)))))))))))...)....(((((((........))))))).....((.((..[[[[[[)).))..)))..................................((....))...............((((....))))..................................(((((.(((((.......(((((((((((((((((((((((.......(((((((......((((.(....).)))).......))))))).....))))).))))))))))........(((....)))....))))))))...))))).))))).<((((........))))((((((..(.(.((((.((((((..(((...((((.....))))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).)))).)..((.(...((((((......(((((((((.((((...((((((......))))))...)<)))...((...((.((........))))..))..).))))))))..(.((.......))...)..))))))......).))).((((((....(.(((....))).)((((((((((....((.(((((((.....(((....((...(.((((...(.(.....).).)))).)...))..)).).....)))))...((((..(((.(......))))..)))).....))))..)))))))).))..((((.((.((.....)).)).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.(.(((((.((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)).))))).))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...((((((...((.....)).))))))....[[(((.((...((....(((....))).........(.................)....))....))...(((((........)))))]]((((.((((((.(...((((....)))...(.[[((((((...((((.(((((((((((((((((....{{...)))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....).))..)))))))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((.(((..))).)..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).]..(..(((..((((((.(...((.....((((....)))).....)).)))))..)))))(.(((.........))).)........((..........(((((.......)))))..)..)......)....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.((.(((((..(((((((....((.((.(..........(..(..(.....)............)..)..))).)).....)))))))...(((((.....((((....(.(.......).)...........]]...((.(((....))).))..))))..))))).....))))).))..)))))..(((......[)).)(((((...........].)))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))....((..((((....{..))))..))..((......)).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......(....(..(((((...((.......))...)))))....)....)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))....))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((.(.....}.......).))...)))).))))....)))))))).......((((((.(((.......((.(........(((((((..).)))))).....))).......((((((...((.((.(..(((......)))..).)).)).))))))................))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..))))))..)))))...)))....)))).)))))).))))).. State 6 (S6) of yeast 80S ribosome bound to 2 tRNAs and eEF2 and eEF3 during tranlocation; 25S rRNA 8ylr B 121 3.9 RF00001 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<<............>>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....(.((((...(....)...))).)....)...)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). State 6 (S6) of yeast 80S ribosome bound to 2 tRNAs and eEF2 and eEF3 during tranlocation; 5S rRNA 8ylr C 158 3.9 RF00002 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<(.....>>............).>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... State 6 (S6) of yeast 80S ribosome bound to 2 tRNAs and eEF2 and eEF3 during tranlocation; 5.8S rRNA 8ylr t 75 3.9 RF00005 URS00021ED942_559292 0030533 0006412 559292 agcgccgugacgcaguggaagcgcgcagggcucauaacccugauguccucggaucgaaaccgagcggcgcuacca <<<<<<<...<<<.......>>>..<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((...(((....[..)))..(((((.......))))).....(((((..]....)))))))))))).... State 6 (S6) of yeast 80S ribosome bound to 2 tRNAs and eEF2 and eEF3 during tranlocation; tRNA 8ylr u 74 3.9 RF00005 0030533 559292 agcgccgugacgcaguggaagcgcgcagggcucauaacccugauguccucggaucgaaaccgagcggcgcuacc <<<<<<<...<<<.......>>>..<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>... (((((((...(((....[..)))..(((((.......))))).....(((((..]....))))))))))))... State 6 (S6) of yeast 80S ribosome bound to 2 tRNAs and eEF2 and eEF3 during tranlocation; tRNA 8yno A 12 1.3 39231537 32630 ggacncgagncc ............ ............ RNA duplex containing Formamide; RNA (5'-R(*GP*GP*AP*CP*(5BU)P*CP*GP*AP*GP*(HHU)P*CP*C)-3') 8yno B 12 1.3 39231537 32630 ggacncgagncc ............ ............ RNA duplex containing Formamide; RNA (5'-R(*GP*GP*AP*CP*(5BU)P*CP*GP*AP*GP*(HHU)P*CP*C)-3') 8ynp A 12 1.4 39231537 32630 ggacncgagncc ............ ............ RNA duplex containing Methylformamide; RNA (5'-R(*GP*GP*AP*CP*(5BU)P*CP*GP*AP*GP*(HHX)P*CP*C)-3') 8ynp B 12 1.4 39231537 32630 ggacncgagncc ............ ............ RNA duplex containing Methylformamide; RNA (5'-R(*GP*GP*AP*CP*(5BU)P*CP*GP*AP*GP*(HHX)P*CP*C)-3') 8yoo L5 3670 2.0 RF02543 38942792 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcggcccggcggaucuuucccgcgcgggggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucgggggcccccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcgcucuccccccucccggcgcgccggggggggccgggccaccccucccacggcgcgaccgcuggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccgggggaggccacgcgcgcgucccccgaagagggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcagacccgacgcgccacgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagcggcggcccggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcugggucggucgcggccggcgccuagcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacaugagagacucugaucguuuuuucacugacccggugaggcgggggggcgagccccgaggggcucucgcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccggucccccgccgggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>>..<<<<<<<<<<...<<<<<<<.<<<.....<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>.>>>>>>>>>>..>>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<......>>>..................................<<<<<<<<..<<<.<....<<<<<<<<.<<<.....<<<<<<<<<<<..<<<<<<<...<<..<.....<<<<.<<<..<<<<..>>>>>>>>>>>.>..>>..>>>>...>>>>>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<.<<<<<<<<<<<<<<<...<<..<<<....<<<<......<<<<<<<<..>>>>>>>>.......>>>>...>>>........>>>>>>..>>>>>>>>>>>....................<<<<<<.<<<<<<<............>>>>>>>.<<<<<<.<<<<.<<<<<<<<<<<<<<<<<<<<<<<.<<<<....>>>>.>>>>>>.>>>>.>>>>>>>>>>.>>>...>>>>..>>>>.>>..<<<<<<<<<<.....>>>>>>>>.>>....>>>>>>......>>.>>>>>....>>>>...>>>>>>>>..<<<<........>>>><<<<<<...<<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<......>>>>>>>..<<<<<...<<<..<<<..((((.((((>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>>.<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<....................<<<.<<<<<<<<<...<<<....<<<..<.<<<..<<<<.............>>>>>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.........>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<..........)))).))))...<.....>..................>>>>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<...<....>..>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<..<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<...............>>>>><<.<<<<<<<<<<<..<<..........>>.......>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.....<<.....<<<<....>>>>.....>>..>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<<<<<<<.<....>.>.>>.>>>>>>>>>>...<<<<<.....<<<<.....<..............>................<<<<<<<<<<<.....>>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>><<<<....>>>>>>)))].....<<<<<<<..<<<..)))))).>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<...<<<.<<<<<<<]]].>>>>>..>>.>>>..>>>>...>>>><<<<....<<<<<...........>>>>>....>>>>.>>>...>.>>>>>>.....<<<<<<<.<<..<<<<....<<<........<<<<<.<<<<....>>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>..............>>>>..>>>>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<.<..<<<<<......>>>>>..>>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((...((((((((((.....)))))).)))).....)))....((((((((((...(((((((.(((.....((((((((..({((((......)))))....[[(...).(((....}]])))...).)))))))).)))))))))..))))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....(((((((((((..(((((((...((...(....((((.((...((.(..).)).)))))))...))..))))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((.((.((((......((((((((())))))))).......))))).))))........))))))..)))))))))))......{.............((((((.((((((.....(.....)..)))))).((((((.((((.(((((((((((((((((((((((..(((....)))..)))))).)))).)))))))))).)))...))))..)))).))..((((((((((.....)))))))).))..[.)))))).....))).)))))...)))))...)))))))).<((((........))))((((((....(((((((((((((..(((..((((..........)))..)..)))...((....))...((((.((......).)))))..(((((...(((..(((..[[[[.[[[[)))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......B)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((....................(((.((((((((....(((....(((..(.(((..(((...............)))))).)..)))..)).)....))))))...(((((((((.(......))))))))))....))))))))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.....A.(((((.(((...((...([...)))...))).....(...((.]....)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((........}.]]]].]]]]]..(......)....(...)........)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((..(((((((...((.....)).))))))....[[(((.((...((....(((....)))..........((.((((....(....)...))))))......))....))...(((((........)))))]]((((....(((((...(((((((....)))))))..((((....)))...(...((((((...(((((((((((((((((((((((..{{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).))).))).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((...(([...)...])........)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(..........((((....))))........)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.(((((((((.((((((((((((...........)).))))))))))...(((((.....((((.....((............))................((((((((((.......))))))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..b.))..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}}.)))))..)).))...))))...)))).((((...((((.....a.......))))...))))..)))...).)))))).....(((((((.((..((((.(..(((........(((((.((((.(.))))).))))).......)))...(((...((.....((((.(((((((......)))))))))))....))...)))...........)..))))..)))))))))(((((.(..(.......)..)....((.(((((((.((.....((((.(..(((((......)))))..)))))....))....)))).))).))..))))).. Cryo-EM structure of the human 80S ribosome with 100 um Tigecycline; 28S rRNA 8yoo L7 120 2.0 RF00001 38942792 0003735 0005840 9606 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. Cryo-EM structure of the human 80S ribosome with 100 um Tigecycline; 5S rRNA 8yoo L8 156 2.0 RF00002,RF02540 38942792 0003735 0005840 9606 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<<<<....>>>>.....<.<<<......>>.............>>>..>...>>>....<<....>><<<<<<<<<.....>>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))(((((((((.....))))))))).................... Cryo-EM structure of the human 80S ribosome with 100 um Tigecycline; 5.8S rRNA 8yoo S2 1719 2.0 RF01960,RF02542,RF01959,RF00177 38942792 0003735 0005840 9606 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucgcuccucucccacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgccccccguggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuccgcgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuuggcucucggcgcccgaagcauuuacuuugaaaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggucggcccacggcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<....<<....<<<<<..................<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<<.....>.>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<<......>>>>>>>>.>>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....<<<<<<<<<.<<<....>>>..>>>>>.>>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<......<<.<........>.>>...<<<<<<.<.......<<...<.......>.<<<<.......>>>>...>>......>.>>>..>>>........<.<<.<<<<<<<...............>>>>>>>.>>.>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<<....>>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<......>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<.......>>>>.>>>>.....>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<...<<<...................>>>.....>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..((....(((((...((.............((.....((.(((.....))).))......))......)).((((...((((........))))...))))((..(((((...(......)..)))))......)).(.((((.((((......))))))))))).)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).).....(((((((((.(((....)))..))))).))))......((..(...........)..)).........((((([[....(.((((.....((..]])).......))))))))))..)))))).)))..[......(.([[...(.(.((...(((..(......((............))...((((((.(.......((..((.......)).(((.......)))....))......).)))..)))........(.((.(.((((.................)))).).)).)....)....(((..(...(...((((..(((.((((((((...((........))......)))))))).))).......((....))...))))..)...)...))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.(((((....))))))))))).)..)))...((..]]))...))...].))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((...(...((((..((((((((((((.......)))).)))).....))))..))))..).....(((((.....)))))........)))....))).))).....).))))).....).)))))...)).)))).))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..((((.((...(((((....(.....................)......)))))...)).))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}........ Cryo-EM structure of the human 80S ribosome with 100 um Tigecycline; 18S rRNA 8yop L5 3771 2.2 RF02543 38942792 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcggcccggcggaucuuucccgcgcgggggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucgggggcccccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcgcucuccccccucccggcgcgccggggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccgggggaggccacgcgcgcgucccccgaagagggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcagacccgacgcgccacgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagcggcggcccggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcugggucggucgcggccggcgccuagcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacaugagagguguagaauaagugggaggcccccggcgcccccccgguguccccgcgaggggcccggggcgggguccgccggcccugcgggccgccggugaaauaccacuacucugaucguuuuuucacugacccggugaggcgggggggcgagccccgaggggcucucgcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccggucccccgccgggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>>..<<<<<<<<<<...<<<<<<<.<<......<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>..>>>>>>>>>..>>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<<<..<<<<<<<...<<..<<....<<<<.<<<..<<<<..>>>>>>>>>>>>>..>>..>>>>...>>>>>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<<<<<<<<<<<<<<<<<...<<..<<<.<..<<<<......<<<<<<<<..>>>>>>>>.......>>>>..>>>>........>>>>>>..>>>>>>>>>>>....................<<<<<<.<<<<<<<............>>>>>>>.<<<<<<.<<<<.<<<<<<<<<<<.<<<<<.<<<<<<<...........>.>>>>>>.>>>>>.>.>>>>>>>.>>>...>>>>..>>>>.>>..<<<<<<<<<<.....>>>>>>>>.>>....>>>>>>.....>>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<......>>>>>>>..<<<<<...<<<..<<<..((((.((((>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<....................<<<.<<<<<<<<<...<<<....<<<..<.<<<..<.<<.............>>.>>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.........>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<..........)))).))))...<.....>..................>>>>>>>>>....>>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<...<....>..>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<..<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<...............<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<..<<..........>>.......>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.....<<.....<<<<....>>>>.....>>..>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<<<<<<..<.................................<........................>.............................................>...>>.>>>>>>>>>>...<<<<<.....<<<<.....<..............>................<<<<<<<<<<.......>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>><<<<....>>>>>>)))].....<<<<<<<..<<<..)))))).>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<]]].>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.....<<<<<<<.<<..<<<<....<<<........<<<<<.<<<<....>>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>..............>>>>..>>>>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<.<..<<<<<......>>>>>..>>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((...((((((((((.....)))))).)))).....)))....((((((((((...(((((((.((......((((((((..({((((......)))))....[[(...).(((....}]])))...).)))))))..)))))))))..))))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....(((((((((((..(((((((.(.((...(....((((.(((..((.(..).))))))))))...)).)))))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((.(..((((......((((((((())))))))).......))))..))))........))))))..)))))))))))....................((((((.((((((.....(.....)..)))))).((((((.((((.(((((((((((.(((((.(((..(..............)..)))).)))).).))))))).)))...))))..)))).))..((((((((((.....)))))))).))..[.)))))).....))).)))))...)))))...)))))))).<((((........))))((((((....(((((((((((((..(((..(((((........))))..)..)))...((....))...((((.((......).)))))..(((((...(((..(((..[[[[.[[[[)))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((....................(((.((((((((....(((....(((..(.(((..(..................).))).)..)))..)).)....))))))...(((((((((.(......))))))))))....))))))))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.....{.(((((.(((...((...([...)))...))).....(...((.]....)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((..........]]]].]]]]]..(......)....(...)........)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((..(((((((...((.....)).))))))....[[(((.((...((....(((....)))..........((.((((....(....)...))))))......))....))...(((((........)))))]]((((....(((((...(((((((....)))))))..((((....)))...(...((((((...(((((((((((((((((((((((..{{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).))).))).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((...(([...)...])........)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(..........((((....))))........)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.(.......((((.((((((..(((((.(((((((((.((((((((((((...............................................................................................................)).))))))))))...(((((.....((((.....((............))................((((((((((.......))))))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a..)..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}}.)))))..)).))...))))...)))).((((...((((.....}.......))))...))))..)))...).)))))).....(((((((.((..((((.(..(((........(((((.((((.(.))))).))))).......)))...(((..(((.....((((.(((((((......)))))))))))....)))..)))...........)..))))..)))))))))(((((.(..(.......)..)....((.(((((((.((.....((((.(..(((((......)))))..)))))....))....)))).))).))..))))).. Cryo-EM structure of the human 80S ribosome with 4 um Tigecycline; 28S rRNA 8yop L7 120 2.2 RF00001 38942792 0003735 0005840 9606 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. Cryo-EM structure of the human 80S ribosome with 4 um Tigecycline; 5S rRNA 8yop L8 156 2.2 RF00002,RF02540 38942792 0003735 0005840 9606 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<<<<....>>>>.....<.<<<......>>.............>>>..>...>>>....<<....>><<<<<<<<<.....>>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))(((((((((.....))))))))).................... Cryo-EM structure of the human 80S ribosome with 4 um Tigecycline; 5.8S rRNA 8yop S2 1740 2.2 RF01960,RF02542,RF01959,RF00177 URS00021ED8E3_9606 38942792 0003735 0005840 9606 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucgcuccucucccacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgccccccguggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuccgcgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcgggcguccccgcccucucggccggggcccgaagcauuuacuuugaaaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggucggcccacggcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<....<<....<<<<<..................<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<<.....>.>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<<......>>>>>>>>.>>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....<<<<<<<<<.<<<....>>>..>>>>>.>>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<.......................<<.<<...........>>>>...<<<<<<.<.......<<...<.......>.<<<<.......>>>>...>>......>.>>>..>>>........<.<<.<<<<<<<...............>>>>>>>.>>.>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<.......>>>>.>>>>.....>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<...<<<...................>>>.....>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..((....(((((...((.............((.....((.(((.....))).))......))......)).((((...((((........))))...))))((..(((((...(......)..)))))......)).(.((((.((((......))))))))))).)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).).....(((((((((.(((....)))..))))).))))....(.((..(...........)..))......)..((((([[....(.((((.....((..]])).......))))))))))..)))))).)))..[......(.([[...(.(.((...(((..(.......................((.(.............)))...((((((.(.......((..((.......)).(((.......)))....))......).)))..)))........(.((.(.(((((...............))))).).)).)....)....(((..(...(...((((..(((.((((((((...((........))......)))))))).))).......((....))...))))..)...)...))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.((((......)))))))))).)..)))...((..]]))...))...].))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((.(..(((.(((((....)))..(.((......)))...)).)))....(((...(...((((..((((((((((((.......)))).)))).....))))..))))..).....(((((.....)))))........))).)..))).))).....).))))).....).)))))...)).)))).))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..((((.((...(((((....(.....................)......)))))...)).))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}........ Cryo-EM structure of the human 80S ribosome with 4 um Tigecycline; 18S rRNA 8yuo A 1519 2.25 RF00177,RF01959,RF02542,RF01960 39300229 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugccggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<......>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<.>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<..>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>.....<...>...>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((.(((((......)))))..)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....(((.((.)).))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....(((.((((.......)))).))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((((())))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...((.(((....))).)).....(.....)..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... E. coli 70S ribosome complexed with P. putida tRNAIle2 at the A-site and P-site; 16S rRNA 8yuo a 2753 2.25 RF02540,RF02541,RF02543,RF00002 39300229 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagcgucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcgcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<..>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<..>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.......<<<<<<.<<....>>..>>>>>>.......>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<..>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.(((.(.....((((.((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))).))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((.((((.....))))..))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(())...)))..))))).))...........]]].)...))))))))))...)))))))((((((((()))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((())))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). E. coli 70S ribosome complexed with P. putida tRNAIle2 at the A-site and P-site; 23S rRNA 8yuo b 119 2.25 RF00001 39300229 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<...<...<<<<<<<<...>>>>>>>>.....>.>>...>>>>>>>>>> ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))) E. coli 70S ribosome complexed with P. putida tRNAIle2 at the A-site and P-site; 5S rRNA 8yuo W 11 2.25 39300229 562 acuauaauaua ........... ........... E. coli 70S ribosome complexed with P. putida tRNAIle2 at the A-site and P-site; mRNA 8yuo X 77 2.25 39300229 1211579 gggccuauagcucagnnggnnagagcagaggacunaunauccuuugnnccacggnucaaguccgugugggcccacca <<<<<<...<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>.>>>>>>.... ((.((((..((((.....[...))))(((((.........)))))....(((((..]....))))))))).)).... E. coli 70S ribosome complexed with P. putida tRNAIle2 at the A-site and P-site; A-site tRNAIle2 8yuo V 77 2.25 39300229 1211579 gggccuauagcucagnnggnnagagcagaggacunaunauccuuugnnccacggnucaaguccgugugggcccacca <<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((.(..((((.....[...))))(((((.........)))))....(((((..]....)))))).))))).... E. coli 70S ribosome complexed with P. putida tRNAIle2 at the A-site and P-site; A-site tRNAIle2 8yup A 1519 2.39 RF00177,RF01959,RF02542,RF01960 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugccggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<......>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<.>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<..>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>.............>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<...<<....>>..>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((.(((((......)))))..)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....))).....((.((.)).))..)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....(((.((((.......)))).))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((((())))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((.(((....))).)))....(.....)..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... E. coli 70S ribosome complexed with P. putida tRNAIle2 and A4 mRNA; 16S rRNA 8yup a 2753 2.39 RF02540,RF02541,RF02543,RF00002 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagcgucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcgcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<..>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<..>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<<.<<....>>..>>>>>>..>....>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<..>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((..(((((.((.(((...(((((......)))))[[(...).(((.....]])))...)))...)).)))))..)))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((.((((.....))))..))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(.(.....{.(())...).)..))))).))...........]]].)...))))))))))...)))))))((((((((()))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((())))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). E. coli 70S ribosome complexed with P. putida tRNAIle2 and A4 mRNA; 23S rRNA 8yup b 119 2.39 RF00001 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>> ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))) E. coli 70S ribosome complexed with P. putida tRNAIle2 and A4 mRNA; 5S rRNA 8yup V 76 2.39 RF00005 0030533 679895 guccccuucgucuagaggcccaggacaccgcccunucncggcgguaacaggggnucgaauccccuaggggacgcca <<<<<<<..<<<<.........>>>><<<<<<.......>>>>>>...<<<<<.......>>>>>>>>>>>>.... (((((((..(((.....[.....)))((((((.......))))))...(((((..]....)))))))))))).... E. coli 70S ribosome complexed with P. putida tRNAIle2 and A4 mRNA; P-site tRNAGlu 8yup W 12 2.39 562 acugagauaaaa ............ ............ E. coli 70S ribosome complexed with P. putida tRNAIle2 and A4 mRNA; mRNA 8yup X 77 2.39 1211579 gggccuauagcucagnnggnnagagcagaggacunaunauccuuugnnccacggnucaaguccgugugggcccacca <<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... ((.((.(..((((.....[...))))(((((.........)))))....(((((..]....)))))).)).)).... E. coli 70S ribosome complexed with P. putida tRNAIle2 and A4 mRNA; A-site tRNAIle2 8yuq A 1519 2.41 RF00177,RF01959,RF02542,RF01960 39300229 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugccggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<......>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<.>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<..>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>.....<...>...>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((.(((((......)))))..)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((.)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((((.......)))))))).....)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((((())))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((.(((....))).)))....(.....)..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... E. coli 70S ribosome complexed with P. putida tRNAIle2 and dA4 mRNA; 16S rRNA 8yuq a 2753 2.41 RF02540,RF02541,RF02543,RF00002 39300229 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagcgucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcgcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<.<....<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>..>>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<..>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<..>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<<.<<....>>..>>>>>>..>....>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<..>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((..((((.(((.(((...(((((......)))))[[(...).(((.....]])))...)))...))).))))..)))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((.(((.....))).).))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(())...)))..))))).))...........]]].)...))))))))))...)))))))((((((((()))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((())))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). E. coli 70S ribosome complexed with P. putida tRNAIle2 and dA4 mRNA; 23S rRNA 8yuq b 119 2.41 RF00001 39300229 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>> ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))) E. coli 70S ribosome complexed with P. putida tRNAIle2 and dA4 mRNA; 5S rRNA 8yuq V 76 2.41 RF00005 39300229 0030533 679895 guccccuucgucuagaggcccaggacaccgcccunucncggcgguaacaggggnucgaauccccuaggggacgcca <<<<<<<..<<<<.........>>>><<<<<<.......>>>>>>...<<<<<.......>>>>>>>>>>>>.... (((((((..(((.....[.....)))((((((.......))))))...(((((..]....)))))))))))).... E. coli 70S ribosome complexed with P. putida tRNAIle2 and dA4 mRNA; P-site tRNAGlu 8yuq W 12 2.41 39300229 562 acugagauanaa ............ ............ E. coli 70S ribosome complexed with P. putida tRNAIle2 and dA4 mRNA; mRNA 8yuq X 77 2.41 39300229 1211579 gggccuauagcucagnnggnnagagcagaggacunaunauccuuugnnccacggnucaaguccgugugggcccacca <<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... ((.((((..((((.....[...))))(((((.........)))))....(((((..]....))))))))).)).... E. coli 70S ribosome complexed with P. putida tRNAIle2 and dA4 mRNA; A-site tRNAIle2 8yur A 1519 2.47 RF00177,RF01959,RF02542,RF01960 39300229 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugccggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<......>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<.>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>...<.<<<<<.......<<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<..>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>.............>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<...<<<..>>>..>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(.(..((.((..(((((((((......)))))).)))))..))).)......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((.)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((.(.........)))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((.......(((....)))......))))...(.(((((...(..(.(((.((((.......)))).))).)...)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((((())))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((.(((....))).)))....(.....)..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... E. coli 70S ribosome complexed with P. putida tRNAIle2 and Am4 mRNA; 16S rRNA 8yur a 2753 2.47 RF02540,RF02541,RF02543,RF00002 39300229 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagcgucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcgcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<..>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<..>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<<.<<....>>..>>>>>>..>....>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<..>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......((((.((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))).))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))..(((((((..((((((((((.....(((...(((.((((...(((((((.....))))).))...)))).)))..)).).....)))))).)))..)))))))).....(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(())...)))..))))).))...........]]].)...))))))))))...)))))))((((((((()))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((())))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). E. coli 70S ribosome complexed with P. putida tRNAIle2 and Am4 mRNA; 23S rRNA 8yur b 119 2.47 RF00001 39300229 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>> ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))) E. coli 70S ribosome complexed with P. putida tRNAIle2 and Am4 mRNA; 5S rRNA 8yur V 76 2.47 RF00005 39300229 0030533 679895 guccccuucgucuagaggcccaggacaccgcccunucncggcgguaacaggggnucgaauccccuaggggacgcca <<<<<<<..<<<<.........>>>><<<<<<.......>>>>>>...<<<<<.......>>>>>>>>>>>>.... (((((((..(((.....[.....)))((((((.......))))))...(((((..]....)))))))))))).... E. coli 70S ribosome complexed with P. putida tRNAIle2 and Am4 mRNA; P-site tRNAGlu 8yur W 12 2.47 39300229 562 acugagauanaa ............ ............ E. coli 70S ribosome complexed with P. putida tRNAIle2 and Am4 mRNA; mRNA 8yur X 77 2.47 39300229 1211579 gggccuauagcucagnnggnnagagcagaggacunaunauccuuugnnccacggnucaaguccgugugggcccacca <<<<<<<..<<<<.........>>>><<<<<<.......>>>>>>....<<<<<.......>>>>>>>>>>>>.... ((.((((..((((.....[...))))(((((.........)))))....(((((..]....))))))))).)).... E. coli 70S ribosome complexed with P. putida tRNAIle2 and Am4 mRNA; A-site tRNAIle2 8yus A 1519 2.43 RF00177,RF01959,RF02542,RF01960 39300229 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugccggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<......>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<.>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<..>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>.....<...>...>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((.(((((......)))))..)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((.)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(..(.(((.((((.......)))).))).)...)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((((())))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...((.(((....))).)).....(.....)..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... E. coli 70S ribosome complexed with P.putida tRNAIle2 and A(F)4 mRNA; 16S rRNA 8yus a 2753 2.43 RF02540,RF02541,RF02543,RF00002 39300229 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagcgucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcgcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<..>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<..>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<..<<....>>...>>>>>..>....>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<..>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((..((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))))))..)))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((.((((.....))))..))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(.(.....{.(())...).)..))))).))...........]]].)...))))))))))...)))))))((((((((()))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((())))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). E. coli 70S ribosome complexed with P.putida tRNAIle2 and A(F)4 mRNA; 23S rRNA 8yus b 119 2.43 RF00001 39300229 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>> ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))) E. coli 70S ribosome complexed with P.putida tRNAIle2 and A(F)4 mRNA; 5S rRNA 8yus V 76 2.43 RF00005 39300229 0030533 679895 guccccuucgucuagaggcccaggacaccgcccunucncggcgguaacaggggnucgaauccccuaggggacgcca <<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>....<<<<<.......>>>>>>>>>>>>.... (((((((..(((.....[.....)))((((((.......))))))...(((((..]....)))))))))))).... E. coli 70S ribosome complexed with P.putida tRNAIle2 and A(F)4 mRNA; P-site tRNAGlu 8yus W 12 2.43 39300229 562 acugagauanaa ............ ............ E. coli 70S ribosome complexed with P.putida tRNAIle2 and A(F)4 mRNA; mRNA 8yus X 77 2.43 39300229 1211579 gggccuauagcucagnnggnnagagcagaggacunaunauccuuugnnccacggnucaaguccgugugggcccacca <<<<<<...<<<<.........>>>><<<<<<.......>>>>>>....<<<<<.......>>>>>.>>>>>>.... ((.((((..((((.....[...))))(((((.........)))))....(((((..]....))))))))).)).... E. coli 70S ribosome complexed with P.putida tRNAIle2 and A(F)4 mRNA; A-site tRNAIle2 8z4j M 38 2.97 39143216 256318 guuaaaacucuucucaugcuggauucgaaauuaggugc ...................................... ...................................... Cryo-EM structure of CTR-bound type VII CRISPR-Cas complex at substrate-engaged state II; RNA (38-MER) 8z4j N 34 2.97 39143216 256318 cagaacaccuaauuucgaauccagcaugagaagc .................................. .................................. Cryo-EM structure of CTR-bound type VII CRISPR-Cas complex at substrate-engaged state II; RNA (34-MER) 8z4l M 49 2.85 39143216 256318 guuaaaacucuucucaugcuggauucgaaauuaggugcgcuucgcguuu ................................................. ................................................. Cryo-EM structure of CTR-bound type VII CRISPR-Cas complex at substrate-engaged state I; RNA (49-MER) 8z4l N 40 2.85 39143216 256318 cagaagaagcgcaccuaauuucgaauccagcaugagaagc ........................................ ........................................ Cryo-EM structure of CTR-bound type VII CRISPR-Cas complex at substrate-engaged state I; RNA (40-MER) 8z70 2 1771 3.2 RF01960,RF02542,RF01959,RF00177 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugagcuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauu ...<<<<<...((((>>>>><<<<.<<<<<<...<.<...<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<..<<..<<....<<<..................<<....<<.<<<.....>>>.>>.....>>.........<<<<<..<<....>>..>>>>><.<.<<<<<<......[[.((((.<<<....>>>....<<......>>>>>>>>.>...>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>...<<<..>>>.....>>>>>>.........<<<....<<<.....>>>..>>>..>....>.>.....<<<<<<<..<<<<....>>>>..>>>>.>>.>.....<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>>.........<<<{{.....<.<<...<<<.<<....<<<<<<.<<<................>>>.>>>>>>.....<<<<<....................>>>>>....<<<<<.<<.......<<...<.......>..<<<<...>>>>....>>......>>.>>..>>>.........<<...<<<<<<<<.....)))).]].>>>>>>>>..>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>..>.>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..))))..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<......<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>...<<<<<<<.....>>>>>>>......>>>>>....>>>.>>>.....>>>>>>>.......>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>......<....<<<<<<..........>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<.<<<<.<<<<....>>>>.>>>>.>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>........ ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[[.[[[.(.(....).).....(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....))..)..)))))).).....(.(((...((((.}...))).))))).)....).).....(((((((..((((....))).).)))).)))....(.((..(...........)..))......)..((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((................))).))))))......((((....................)))).....(((((.((.......((..((.......)).(((.....)))....))......)).))..)))........((....(.((.((......]].]]]]..)).)).)...)..)..))...(((.(((.((...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)).)))..))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].].((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((.(..(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..))))).)..))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....((((((((.......))))))))......))...)))))))))).)...(.(..((.(..((((.((..(.((((((((.(((..(.((..(...((((((..(.((.((((....)))).)).)..))))))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>....... State 1 (S1) of yeast 80S ribosome bound to 2 tRNAs during mRNA decoding; 18S rRNA 8z70 s 76 3.2 RF00005 0030533 559292 gucuccguaguguagcgguuaucacguucgccuaacacgcgaaagguccucgguucgaaaccgggcggaaacacca <<.<<<<..<<<.........>.>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>.>>.... ((..(((..((............)).((((.........)))).....(((((.......))))))))..)).... State 1 (S1) of yeast 80S ribosome bound to 2 tRNAs during mRNA decoding; tRNA 8z70 t 75 3.2 RF00005 URS00021ED942_559292 0030533 0006412 559292 agcgccgugacgcaguggaagcgcgcagggcucauaacccugauguccucggaucgaaaccgagcggcgcuacca <<<<<<<...<<<.......>>>..<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((...(((....[..)))..(((((.......))))).....(((((..]....)))))))))))).... State 1 (S1) of yeast 80S ribosome bound to 2 tRNAs during mRNA decoding; tRNA 8z70 B 121 3.2 RF00001 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). State 1 (S1) of yeast 80S ribosome bound to 2 tRNAs during mRNA decoding; 5S rRNA 8z70 C 158 3.2 RF00002 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... State 1 (S1) of yeast 80S ribosome bound to 2 tRNAs during mRNA decoding; 5.8S rRNA 8z70 A 3187 3.2 RF02540,RF02541,RF02543 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucacacugggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucgaacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauagaggguguagaauaagugggagcuucggcgccagugaaauaccacuaccuuuauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuugguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<.<<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.((......<<<.....))>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<.......<<<<<<<.<<<<<<<<<<<<<<<......<<<<<<<<....<.<<<<<<<..>>>>>>>>......>>>>>>>.>...>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>...>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<..<.<<<<....<.<...>.>..>>>>.>..>>>..>>.>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>................>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>>..<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>.........<<<............>>>.....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<<....<<<....>>>...<...<<<<<<...<<<<.<<<<<<<<<<<<<<<<<<..{{{..>>>>>>....<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>.....<<<<<<<<....>>>>>>>>>>>>.>.>>>>>>>.>>>>.........>>>>>>...>.....>>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<.....<..>......>>>>><<.<<<<<<<<<<<..>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<.....<<<....<<<<<....>>>>.>...>>>..>>>..>>>>><<<............>>>.........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<.<..<<<.<<.<...........<<<......................>>>...>>>.>>>...>.>>>>>>...<<<<<.....<<<<......<.......>..................<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>..>>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<...<<<<<<<<<<.}}}..>>>>..>>>>>>..>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<..<.......>..>.....<<<<<<<<<.<<<....<<<<.<..<<<<<....>>>>>..>>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................((((((.....(...[..)......))))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((..((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))..))....)))))))))))...)....(((((((........))))))).....((.((..[[[[[[)).))..)))..................................((....))...............((((....))))..................................(((((.(((((.......((((((((.((((.(((((((((.......(((((((......((((.((..)).)))).......))))))).....))))).)))).)))).........(((....)))....))))))))...))))).))))).<.(((........))).((((((....(.((((.((((((..(((...((((.....))))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).)))).)..((.(...((((((......(((((((((.((((...((((((......))))))...)<)))...((...((.((........))))..))..).))))))))..(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((....((.(((((((.....(((....(((..(.((((...(.(.....).).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.((.((.....)).)).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((.(((...((.........))...)))................)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...((((((...((.....)).))))))....[[(((.((...((....(((....))).........(.................)....))....))...(((((........)))))]]((((..(((.(((...((((....)))...(.[[((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....).(((((((....))))))).)))).).))))))).))))(...)....))))))...))....)))...))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....((((.((.((..(....(.......((((.....(.[..)......))))((..(((((((.((..)).))..)))))..))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].((..(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((............))).........((..........(((((.......)))))..)..).....))....)).))))))).)..))).)).))))..))))))....)).[..(((((.....>].)))))....(((((..((..((......((((.((((((..((.(..((.(((((..((((.((....((..(.(..........(..(..(......)............)..)..))..)).....)).))))....((.(.....((.(....(.(.......).)...........]]...((.(((....))).))..).))..).))......))))).))...).))..(((......[)).)(((((...........].)))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(..(((((...((.......))...)))))....)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(.(((((....))).)).)....))...)).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......(.((((..((.(.....((.(........(((((((..).)))))).....))).......((((((...((.((.(..(((......)))..).)).)).))))))..............).))..)))).)..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(.((((..)))).)..)))))...)))....)))).)))))).))))).. State 1 (S1) of yeast 80S ribosome bound to 2 tRNAs during mRNA decoding; 25S rRNA 8z71 2 1771 3.6 RF01960,RF02542,RF01959,RF00177 0003735 0005840 559292 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugagcuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauu ...<<<<<...((((>>>>><<<<.<<<<<<...<.<...<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<..<<..<<....<<<..................<<....<<.<<<.....>>>.>>.....>>.........<<<<<..<<....>>..>>>>><.<.<<<<<<......[[.((((.<<<....>>>....<<......>>>>>>>>.>...>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>...<<<..>>>.....>>>>>>.........<<<....<<<.....>>>..>>>..>....>.>.....<<<<<<<..<<<<....>>>>..>>>>.>>.>.....<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>>.........<<<{{.....<.<<...<<<.<<....<<<<<<.<<<................>>>.>>>>>>.....<<<<<....................>>>>>....<<<<<.<<.......<<...<.......>..<<<<...>>>>....>>......>>.>>..>>>.........<<...<<<<<<<<.....)))).]].>>>>>>>>..>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>..>.>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..}}>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..))))..<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<......<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>...<<<<<<<.....>>>>>>>......>>>>>....>>>.>>>.....>>>>>>>.......>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>......<....<<<<<<..........>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<.<<<<.<<<<....>>>>.>>>>.>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>........ ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[[.[[[.(.(....).).....(......).)))))).)...).(.((((..((((..).))).)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....))..)..)))))).).....(.(((...((((.}...))).))))).)....).).....(((((((..((((....))).).)))).)))....(.((..(...........)..))......)..((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((................))).))))))......((((....................)))).....(((((.((.......((..((.......)).(((.....)))....))......)).))..)))........((....(.((.((......]].]]]]..)).)).)...)..)..))...(((.(((.((...((((..((..((((((.....((........))........))))))..)).......((....))...))))..)).)))..))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].].((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((.(..(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..))))).)..))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....((((((((.......))))))))......))...)))))))))).)...(.(..((.(..((((.((..(.((((((((.(((..(.((..(...((((((..(.((.((((....)))).)).)..))))))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>....... State 1a (S1a) of yeast 80S ribosome bound to open eEF3 and 2 tRNAs and eEF1A during mRNA decoding; 18S rRNA 8z71 s 76 3.6 RF00005 0030533 9986 gucuccguaguguagcgguuaucacguucgccuaacacgcgaaagguccucgguucgaaaccgggcggaaacacca <<.<<<<..<<<.........>.>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>.>>.... ((..(((..((............)).((((.........)))).....(((((.......))))))))..)).... State 1a (S1a) of yeast 80S ribosome bound to open eEF3 and 2 tRNAs and eEF1A during mRNA decoding; tRNA 8z71 t 75 3.6 RF00005 URS00021ED942_559292 0030533 0006412 559292 agcgccgugacgcaguggaagcgcgcagggcucauaacccugauguccucggaucgaaaccgagcggcgcuacca <<<<<<<...<<<.......>>>..<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((...(((....[..)))..(((((.......))))).....(((((..]....)))))))))))).... State 1a (S1a) of yeast 80S ribosome bound to open eEF3 and 2 tRNAs and eEF1A during mRNA decoding; tRNA 8z71 B 121 3.6 RF00001 0003735 0005840 559292 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<..............>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). State 1a (S1a) of yeast 80S ribosome bound to open eEF3 and 2 tRNAs and eEF1A during mRNA decoding; 5S rRNA 8z71 C 158 3.6 RF00002 0003735 0005840 559292 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... State 1a (S1a) of yeast 80S ribosome bound to open eEF3 and 2 tRNAs and eEF1A during mRNA decoding; 5.8S rRNA 8z71 A 3187 3.6 RF02540,RF02541,RF02543 0003735 0005840 559292 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucacacugggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucgaacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagacauagaggguguagaauaagugggagcuucggcgccagugaaauaccacuaccuuuauaguuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuugguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<...>>>>>>.>>.......>>....<<<<<<.<<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.((......<<<.....))>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<.......<<<<<<<.<<<<<<<<<<<<<<<......<<<<<<<<....<.<<<<<<<..>>>>>>>>......>>>>>>>.>...>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>...>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<..<.<<<<....<.<...>.>..>>>>.>..>>>..>>.>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>................>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>>..<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>.........<<<............>>>.....>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<<....<<<....>>>...<...<<<<<<...<<<<.<<<<<<<<<<<<<<<<<<..{{{..>>>>>>....<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>.....<<<<<<<<....>>>>>>>>>>>>.>.>>>>>>>.>>>>.........>>>>>>...>.....>>>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<...............<<<<<.....<..>......>>>>><<.<<<<<<<<<<<..>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<.....<<<....<<<<<....>>>>.>...>>>..>>>..>>>>><<<............>>>.........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<.<..<<<.<<.<...........<<<......................>>>...>>>.>>>...>.>>>>>>...<<<<<.....<<<<......<.......>..................<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>..>>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<.<.<<<<<<...............>>>>>>.><<<<<...<<<<...<<<<<<<<<<.}}}..>>>>..>>>>>>..>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<..<.......>..>.....<<<<<<<<<.<<<....<<<<.<..<<<<<....>>>>>..>>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................((((((.....(...[..)......))))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((..((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))..))....)))))))))))...)....(((((((........))))))).....((.((..[[[[[[)).))..)))..................................((....))...............((((....))))..................................(((((.(((((.......((((((((.((((.(((((((((.......(((((((......((((.((..)).)))).......))))))).....))))).)))).)))).........(((....)))....))))))))...))))).))))).<.(((........))).((((((....(.((((.((((((..(((...((((.....))))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).)))).)..((.(...((((((......(((((((((.((((...((((((......))))))...)<)))...((...((.((........))))..))..).))))))))..(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((....((.(((((((.....(((....(((..(.((((...(.(.....).).)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.((.((.....)).)).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((.(((...((.........))...)))................)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...((((((...((.....)).))))))....[[(((.((...((....(((....))).........(.................)....))....))...(((((........)))))]]((((..(((.(((...((((....)))...(.[[((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....).(((((((....))))))).)))).).))))))).))))(...)....))))))...))....)))...))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....((((.((.((..(....(.......((((.....(.[..)......))))((..(((((((.((..)).))..)))))..))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].((..(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((............))).........((..........(((((.......)))))..)..).....))....)).))))))).)..))).)).))))..))))))....)).[..(((((.....>].)))))....(((((..((..((......((((.((((((..((.(..((.(((((..((((.((....((..(.(..........(..(..(......)............)..)..))..)).....)).))))....((.(.....((.(....(.(.......).)...........]]...((.(((....))).))..).))..).))......))))).))...).))..(((......[)).)(((((...........].)))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(..(((((...((.......))...)))))....)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(.(((((....))).)).)....))...)).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......(.((((..((.(.....((.(........(((((((..).)))))).....))).......((((((...((.((.(..(((......)))..).)).)).))))))..............).))..)))).)..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(.((((..)))).)..)))))...)))....)))).)))))).))))).. State 1a (S1a) of yeast 80S ribosome bound to open eEF3 and 2 tRNAs and eEF1A during mRNA decoding; 25S rRNA 8z8x D 18 3.06 38816392 126796 agagaaaucaaggcaguu .<<....>>......... .((....))......... Cryo-EM structure of Thogoto virus polymerase in a transcription initiation conformation; RNA (5'-R(*AP*GP*AP*GP*AP*AP*AP*UP*CP*AP*AP*GP*GP*CP*AP*GP*UP*U)-3') 8z8x E 17 3.06 38816392 126796 gacugccuguuuuugcu ................. ................. Cryo-EM structure of Thogoto virus polymerase in a transcription initiation conformation; RNA (5'-R(*GP*AP*CP*UP*GP*CP*CP*UP*GP*UP*UP*UP*UP*UP*GP*CP*U)-3') 8z90 D 18 2.87 38816392 126796 agagaaaucaaggcaguu .<<....>>......... .((....))......... Cryo-EM structure of Thogoto virus polymerase in transcription initiation conformation 2; RNA (5'-R(*AP*GP*AP*GP*AP*AP*AP*UP*CP*AP*AP*GP*GP*CP*AP*GP*UP*U)-3') 8z90 E 17 2.87 38816392 126796 gacugccuguuuuugcu ................. ................. Cryo-EM structure of Thogoto virus polymerase in transcription initiation conformation 2; RNA (5'-R(*GP*AP*CP*UP*GP*CP*CP*UP*GP*UP*UP*UP*UP*UP*GP*CP*U)-3') 8z97 F 13 2.65 38816392 126796 gccuguuuuugcu ............. ............. Cryo-EM structure of Thogoto virus polymerase in a transcription elongation conformation; RNA (5'-R(*GP*AP*CP*UP*GP*CP*CP*UP*GP*UP*UP*UP*UP*UP*GP*CP*U)-3') 8z99 M 54 3.2 39143216 256318 guuaaaacucuucucaugcuggauucgaaauuaggugcgcuucgcguuuaaguc ...................................................... ...................................................... Cryo-EM structure of NTR-bound type VII CRISPR-Cas complex at substrate-engaged state +I; RNA (54-MER) 8z99 N 46 3.2 39143216 256318 cagaaaaacgcgaagcgcaccuaauuucgaauccagcaugagaagc .............................................. .............................................. Cryo-EM structure of NTR-bound type VII CRISPR-Cas complex at substrate-engaged state +I; RNA (49-MER) 8z9c M 48 3.01 39143216 256318 guuaaaacucuucucaugcuggauucgaaauuaggugcgcuucgcguu ................................................ ................................................ Cryo-EM structure of NTR-bound type VII CRISPR-Cas complex at substrate-engaged state I; RNA (48-MER) 8z9c N 41 3.01 39143216 256318 cagaacgaagcgcaccuaauuucgaauccagcaugagaagc ......................................... ......................................... Cryo-EM structure of NTR-bound type VII CRISPR-Cas complex at substrate-engaged state I; RNA (41-MER) 8z9e M 39 3.13 39143216 256318 guuaaaacucuucucaugcuggauucgaaauuaggugcg ....................................... ....................................... Cryo-EM structure of NTR-bound type VII CRISPR-Cas complex at substrate-engaged state II; RNA (39-MER) 8z9e N 34 3.13 39143216 256318 cagaacaccuaauuucgaauccagcaugagaagc .................................. .................................. Cryo-EM structure of NTR-bound type VII CRISPR-Cas complex at substrate-engaged state II; RNA (34-MER) 8z9h F 13 2.7 38816392 126796 gccuguuuuugcu ............. ............. Cryo-EM structure of Thogoto virus polymerase in a transcription elongation-reception conformation; RNA (5'-R(*GP*AP*CP*UP*GP*CP*CP*UP*GP*UP*UP*UP*UP*UP*GP*CP*U)-3') 8z9r F 13 2.58 38816392 126796 gccuguuuuugcu ............. ............. Cryo-EM structure of Thogoto virus polymerase in a replication elongation-reception conformation; RNA (5'-R(*GP*AP*CP*UP*GP*CP*CP*UP*GP*UP*UP*UP*UP*UP*GP*CP*U)-3') 8z9r G 10 2.58 38816392 126796 ngcaaaaaca .......... .......... Cryo-EM structure of Thogoto virus polymerase in a replication elongation-reception conformation; RNA (5'-D(*(ATP))-R(P*GP*CP*AP*AP*AP*AP*AP*CP*A)-3') 9ash R 37 2.58 38989619 1360 acgagaacgcagcaccagcuguccaaccugaagaaga ..................................... ..................................... Cryo-EM structure of the active Lactococcus lactis Csm bound to target in post-cleavage stage; CRISPR RNA 9ash T 22 2.58 38989619 1360 cuucuucagguuggacagcugg ...................... ...................... Cryo-EM structure of the active Lactococcus lactis Csm bound to target in post-cleavage stage; Target RNA 9asi R 37 2.79 38989619 1360 acgagaacgcagcaccagcuguccaaccugaagaaga ..................................... ..................................... Cryo-EM structure of the active Lactococcus lactis Csm bound to target in pre-cleavage stage; CRISPR RNA 9asi T 29 2.79 38989619 1360 cuucuucagguuggacagcuggugcugcc ............................. ............................. Cryo-EM structure of the active Lactococcus lactis Csm bound to target in pre-cleavage stage; Target RNA 9ax7 A 1519 2.63 RF00177,RF01959,RF02542,RF01960 39222680 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugccggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<......>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<.>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<..>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<..<.<<<<<<<........>>>>>>>>...>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((.((......)).))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((.)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....(((.((((.......)))).))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((((())))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((.(((....))).)))...(......)..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....))))))).....(((((.....)))))........)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... 70S initiation complex (tRNA-fMet M1 + CUG start codon); 16S ribosomal RNA 9ax7 Z 75 2.63 RF00005 39222680 0030533 562 gcgggguggagcagccgguagcucgucgcgcucauaacgcgaaggucgucgguucaaauccggcccccgcaacca <<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((.....[..)))).(((((.......))))).....(.(((..]....))).)))))))..... 70S initiation complex (tRNA-fMet M1 + CUG start codon); P-site tRNA-fMet M1 9ax7 a 2753 2.63 RF02540,RF02541,RF02543,RF00002 39222680 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagcgucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcgcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<..>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<..>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<<.<<....>>..>>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<..>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>.(<<...<<<<<<<...<<<<<<.......>>>>>>.....<<)..(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((.(((.(((...(((((......)))))[[(...).(((.....]])))...)))...))).)))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))..(((((((..((((((((((.....(((...(((.((((...((.((((.....))))..))...)))).)))..)).).....)))))).)))..)))))))).....(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(())...)))..))))).))...........]]].)...))))))))))...)))))))((((((((()))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((())))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).).....((.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..))....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). 70S initiation complex (tRNA-fMet M1 + CUG start codon); 23S ribosomal RNA 9ax7 b 119 2.63 RF00001 39222680 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>> ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))) 70S initiation complex (tRNA-fMet M1 + CUG start codon); 5S ribosomal RNA 9ax8 X 118 2.6 RF00001 39222680 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))). 70S initiation complex (tRNA-fMet M1, initiation factor 2 + CUG start codon); 5S ribosomal RNA 9ax8 a 1539 2.6 RF01959,RF00177,RF02542,RF01960 39222680 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<.<<<<......>>.>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<...<<<.....>>>.>....>>>>>>>.....<<<<<.....>>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((...((((((((......)))))).)).))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(.....(((((....(.(((....))).)......(....)...)))))...).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..((.......))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...((((((......(((..((...(((....)))...))....)))......))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... 70S initiation complex (tRNA-fMet M1, initiation factor 2 + CUG start codon); 16S ribosomal RNA 9ax8 y 77 2.6 RF00005 39222680 0030533 562 cgcgggguggagcagccugguagcucgucgcgcucauaacgcgaagaucgucgguucaaauccggcccccgcaacca ..<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>...... ...((((..((((.........)))).(((((.......))))).....(((((.......)))))))))....... 70S initiation complex (tRNA-fMet M1, initiation factor 2 + CUG start codon); P-site tRNA-fMet M1 9ax8 A 2854 2.6 RF02540,RF02541,RF02543,RF00002 39222680 0003735 0005840 562 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<<<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<.....>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<....<<<.........>>>.....>.......<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<..<<....>>...>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<..............<<.......>>..............>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. 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70S initiation complex (tRNA-fMet M1, initiation factor 2 + CUG start codon); 23S ribosomal RNA 9axt AA 1705 2.4 RF01960,RF02542,RF01959,RF00177 39379376 0003735 0005840 4896 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...<<<<<...[[[[>>>>>[[[[.((((((...[[[..........[[[.[[[..<<....<<....<<.......>>...>>.>>......{{........[[[..{{..{{....[[[.............<<.....<..<<.......>>..>......>>........<<<<<.............>>>>>[.[.((((((.......<<<<<<<<<.<...>>>......<<......>>)))))).]...]...<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>.......]]].....<<<..<<<....>>>...>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]]............<<.......{{...[[[.[[......<<<<.<....>.>>>.>.......<<<<<<.....>>>>>>...<<<<<.<<.......<<...<.......>..<<<.......>>>....>>......>>.>>..>>>.........[[...(((((((.....>>>>>>>...)))))))..]].....]]....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<....>>>>>>>>>>>..>>>...<<..>>>>...>>.....>>>.....<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<...<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<..<........<<.<<<........>>>.>>......>..>>...<<.<<<..<<<<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<..<<<.<.<<..<<<<<<<.<<<<.......>>>>.>>..>>>>>..>>.>>>>.....<<<<<.....>>>>>.........>>>>....>>>.>>>...>.>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<....<<<.<<<......>>>.>>>....>>.......>>>>>>>......<....<<<<<<..........>>>>>>....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<.<.<<...<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<.....>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>>.>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))((((.((((((...(((..........(((.(((..((....((....((.......))...)){))......(((.......(((..((..((....(((.............(......(...((.....))...).......)........(((((.............)))))(.(.((((((.......[[[[[[..((....)).......((......)))))))).)...).(.((((...(((..).))..)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(..(....)..)...)))))).......(.(((...((((.}...))).)))))......))).......(..((((..))))....).....(.((.................))......)..((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......(.({{...(.(.((...(((.((.......((..(....)..)).........(.(((.......))).)....((((.((.......((..((.......)).(((.......)))....))......)).))..)).........((((...(((((((.....]]]]]]..)))))))..)))..)..))...((.(.((.((...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)).))..).)..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((....)))))))))))..)))...((..}}))...))...}.))))).).(((......((((....))))....)))...]]].](((((.(((((((...(...(((((..(((..(((((.......(........)...........((((..(....(((.(........((.(((........))).))......).)))...((.(((.....((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.(((.(.((..(((((...(((.........))).....)))))..)).))))..(..(((((.....))))).....)..)))))....))).))).......))))).....)..))))...)).)))..))).(...(((((((......((....(((.(..(.....).).)))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......)....)))))))))).))..(.(..(..(..(..(.((..(..((((.((.(((..(.((......((.(.....).))......)).)..))).)).)))).)..)).)..)...)..)...)..)..(((((((((....)))))))))>........ Non-translating S. pombe ribosome; 18S ribosomal RNA 9axt B2 3212 2.4 RF02540,RF02541,RF02543 39379376 0003735 0005840 4896 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........................<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<<.......>>>>>>>.>>.......>>....<<<<....<<.<........<<<<..........<<<<......>>>>.((......<<<.....))>>>.......>>>>...........>....>>.....>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<<<<<........<.<<........<<<...........>>>.........>>..>....<<<<<<<.<<<<<<<<<<<<<<<.....<..<<<<<<<......<<<.....>>..>......>>>>>>>.....>.>>>>>.>>>>>>>>>>........<<<.....>>>.....>>>>>>>....>>>>>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<..<<<<.........>>>>..>>>...<<....>>.......<<<<<..<<<<<.....>>>>>...>>>>>.<<<<<<<<.........>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<...<<<<<....<.<<<.....>>>>...>>>>.>..>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<......<..........<<<.<<<<<<<<<........<<<<..<<<...<<.........>>...>>>.........<<......>>....>>>>....>>>>>>>>>>>>..........))).>....>>>>>>.>>>...>>>>>>><<<<<<<<<........>>>>>>>>>....>>>>>>..<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>...........<<<<<......>>>>>......>>....>>...<<<<<........>>>>>))<<<<..<<<<<......<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<.......>>>>>><...<<<<<........<<<<<<<....<<<.....>>>....>>>>>>>....>>>>>....><<<<<<<<.....>>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>...............>>..>>>.>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<.<..<..>...>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<.........>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<...>>>>>>>...<<<<<.....<<<<...<<<........>>>...............<<<<<......>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>..>>.......<<<<<.<<<<<<..<.<<<<<<.......>>.>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]].....<<<<<<<<..<<<<.<.<<<<<.................>>>>>.><<<<<...<<<<....<<<<<<<<<<....>>>>>..>>>>>...>>>>..>>>>>.<<<<....<<<<...........>>>>....>>>>.>>>>....>>>>>>>>.......<<<<..<<<.........<<...............<.....>.............>>........<<<<<<...<<<<<<<<<<<<......>>>>>>>>>>>>.>>>>>>.................>>>..>>>>...<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<.<..<<<<<......>>>>>..>>>>>...>>>....>>>>.>>>>>...>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.(((((((.......))))))).))....)........((((.......(....(...((..(.......({((((......)))))[[(...).(((....}]])))......)..)).....).....)...........))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((((((........(..(..........(...........)...........)...).....((((((((((((((((((((((.......(...(((......(..(......)..).......)))...)......))))).))))))))))........(((.....)))....))))))).....)))))))))))).<((((........))))((((((....((((((.((((((..(((...((((.......))))...)))...((....)).......(((((..(((((.....)))))...))))).((((((((.........))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((........)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((....((.(((((((.....(((....(((....(((......((((.....))))....)))....)))..)).).....)))))...((((.((((.(......))))).)))).....)))).)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((.............(.(((...((.........))...))).........((......))....)........)))))))))))..........]]].)....))))))))))...)))))))(((((((((........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((..(((((((...((.....)).))))))....[[(((.((...((....(((....)))............(.(........).).......))....))...(((((........)))))]]((((..(((((.....((((....)))...(.[[((((((...((((.((((((((((((((((((...{{..))))))(...(((((........((((((.....(((.....))).....))))))....)))))....)((((((((.....)))))))))))).).))))))).))))(...)....))))))...))..........))..))).)))).))).))).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.((((((.(.........)..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((............((((....)))).........))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.((((((((..((.((((...)))).))...(((((.....((((....(...........)...........]]...((.(......).))...))))..))))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......(..(...((((((...((.......))...))))))....)...)........((((.((((((..(.((((.(.......)..)))..).).(((.........))).....)))))..)...))).).....(((((((....))).))))....))..))).))))).....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((....(((.............)))....)))).))))....)))))))).............(.........(.((...................................))).......((((((...((((.((.((((......)))).)).)))).))))))...................).........(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(((.((..)..).)))..)))))...)))....)))).))))))..))))).. Non-translating S. pombe ribosome; 28S ribosomal RNA 9axt B3 119 2.4 RF00001 39379376 0003735 0005840 4896 gucuacggccauaccuaggcgaaaacaccaguucccguccgaucacugcaguuaagcgucugagggccucguuaguacuaugguuggagacaacaugggaauccggggugcuguaggcu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......(((((..((....)).))))).....))))))))))))))). Non-translating S. pombe ribosome; 5S ribosomal RNA 9axt B4 157 2.4 RF00002 39379376 0003735 0005840 4896 aaacuuucagcaacggaucucuuggcucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccuuuggguucuaccaaaggcaugccuguuugagugucauu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<......>>>>>>>>.................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))((((((((......)))))))).................... Non-translating S. pombe ribosome; 5.8S ribosomal RNA 9axu 2 3212 1.94 RF02540,RF02541,RF02543 39379376 0003735 0005840 4896 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........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..[[[..<<.......<<.<<<<<<<.......>>>>>>>.>>.......>>....<<<<...<<<.<...<....<<<<..........<<<<......>>>>.((......<<<.....))>>>.......>>>>........>..>.....>>>...>>>>........<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<<<<<.......<..<<........<<<...........>>>.........>>...>...<<<<<<<.<<<<<<<<<<<<<<<........<<<<<<<.......<<.....>>.........>>>>>>>.......>>>>>.>>>>>>>>>>........<<<.....>>>.....>>>>>>>....>>>>>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<..<<<<<.......>>>>>..>>>...<<....>>.......<<<<<..<<<<<.....>>>>>...>>>>>.<<<<<<<<.........>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<<<....<<<<....<<<<<.....>>>>>..>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<......<..........<<<.<<<<<<<<<..........<<<.<<....<<.........>>....>>.........<<......>>...>>>......>>>>>>>>>>>>..........))).>....>>>>>>.>>>...>>>>>>><<<<<<<<<........>>>>>>>>>....>>>>>><.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>...........<<.<<......>>.>>......>>....>>...<<<<<........>>>>>))<<<<..<<<<<......<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<.......>>>>>><...<<<<<........<<<<<<<....<<<.....>>>....>>>>>>>....>>>>>....><<<<<<<.......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>...............>>..>>>.>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<...............>>>>><<.<<<<<<.<.........>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<......<....<<<<<....>>>>.>...>...>>>>..>>>>><<<<<.........>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<...>>>>>>>...<<<<<.....<<<<...<<..........>>...............<<<<<......>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>>.<<<....>>>.>>))).......((((((..((((.>>>>>>))))))))))..........]]]]..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>>....>..>>.......<<<<<.<<<<<<..<.<<<.<<.......>>..>>>...>.<<<.<.....>.>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]].....<<<<<<<<..<<<<...<<<<<.................>>>>>..<<<<<...<<<<....<<<<<<<<<<....>>>>>..>>>>>...>>>>..>>>>>.<<<<....<<<<...........>>>>....>>>>.>>>>....>>>>>>>>.......<<<<<<<<<.........<<...............<.....>.............>>........<<<<<<...<<<<<<<<<<<<......>>>>>>>>>>>>.>>>>>>.................>>>>>>>>>...<<<<<.....................<<<<<<<<<.<<<....<<<<.<..<<<<<......>>>>>..>>>>>...>>>....>>>>.>>>>>...>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.(((((((.......))))))).))....)........(((.....(..(....(...(((.(.......({((((......)))))[[(...).(((....}]])))......).))).....).....)......).....)))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((((((.......((..(..........(...........)...........)...))....((((((((((((((((((((((...........(((......(............).......)))..........))))).))))))))))........(((.....)))....))))))).....)))))))))))).<((((........))))((((((....((((((.((((((..(((...((((.......))))...)))...((....)).......(((((..(((((.....)))))...))))).((((((((.........))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((........)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((.....((((.....))))...)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))))))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((.(.....{.....(.(((...((.........))...))).........((......))....)......).)))))))))))..........]]].)....))))))))))...)))))))(((((((((........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((..(((((((...((.....)).))))))....[[(((.((...((....(((....)))...............(......)..........))....))...(((((........)))))]]((((..(((((.....((((....)))...(.[[((((((...((((.((((((((((((((((((...{{..))))))(...(((((........((((((.....(((.....))).....))))))....)))))....)((((((((.....)))))))))))).).))))))).))))(...)....))))))...))..........))..))).)))).))).))).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.((((((.(.........)..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((............((((....)))).........))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.((((((((..((.((((...)))).))...(((((.....((((....(...........)...........]]...(............)...))))..))))).....))))))))..)))))..(((......[)).).(((((..........]))))).([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....(((((.(.((((.]]]]]]))))))))))....)}....))))..)))))).......(..(...((((((...((.......))...))))))....)...)........((((.((((((..(.((((.(.......)..)))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))....))..))).))))).....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((....(((.....}.......)))....)))).))))....)))))))).........((((..........(.((.......(........(..).........).....))).......((((((...(((((((.((((......)))).))))))).))))))....................))).)....(((((.(..(.......)..)...(.(((((((((.(((....((((.(..(((.(......).)))..)))))...)))....)))).))))))..))))).. Non-translating S. pombe ribosome large subunit; 28S ribosomal RNA 9axu 3 119 1.94 RF00001 39379376 0003735 0005840 4896 gucuacggccauaccuaggcgaaaacaccaguucccguccgaucacugcaguuaagcgucugagggccucguuaguacuaugguuggagacaacaugggaauccggggugcuguaggcu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (.(((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......(((((..((....)).))))).....))))))))))))).). Non-translating S. pombe ribosome large subunit; 5S ribosomal RNA 9axu 4 157 1.94 RF00002 39379376 0003735 0005840 4896 aaacuuucagcaacggaucucuuggcucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccuuuggguucuaccaaaggcaugccuguuugagugucauu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<......>>>>>>>>.................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))((((((((......)))))))).................... Non-translating S. pombe ribosome large subunit; 5.8S ribosomal RNA 9axv AA 1705 2.4 RF01960,RF02542,RF01959,RF00177 39379376 0003735 0005840 4896 uaccugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaaguacugugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguaccucuacuuggauaaccgugguaauucuagagcuaauacaugcuaaaaaucccgacuuuuuuggaagggauguauuuauuagauaaaaaaccaaugccuucgggcuuuuuuuggugagucauaauaacuuuucgaaucgcauggccuugcgccggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauagaggccuaccaugguuuuaacggguaacggggaauuaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaaucccgacacggggagguagugacaagaaauaacaaugcagggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugagccuggucaccggggucguuaaccuucuggcaaaaccaggacuuuuaccuugaaaaaauuagaguguucaaagcaggcaaguuuugcucgaauacauuagcauggaauaauaaaauaggacgugugguucuauuuuguugguuucuaggaccgccguaaugauuaauagggauagucgggggcauucguauucaauugucagaggugaaauucuuggauuuauugaagacgaacuacugcgaaagcauuugccaaggauguuuucauuaaucaagaacgaaaguuaggggaucgaagacgaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggcaauguuucucgacuugcucggcaccuuacgagaaaucaaagucuuuggguuccggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccacaauggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacauaguaaggauugacagauugagagcucuuucuugauucuaugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccugcuaaauagcuggaucagccauuuuggcugaucauuagcuucuuagagggacuauuggcauaaagccaauggaaguuugaggcaauaacaggucugugaugcccuuagauguucugggccgcacgcgcgcuacacugacggagccaacgaguuauccuuggccggaaggucuggguaaucuuguuaaacuccgucgugcuggggauagagcauugcaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugaauacgucccugcccuuuguacacaccgcccgucgcuacuaccgauugaauggcuuagugaggccucuggauuggcauugccgagaaguuggacaaacuuggucauuuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<...[[[[>>>>>[[[[.((((((...[[[..........[[[.[[[..<<....<.....<<.......>>....>.>>......{{........[[[..{{..{{....[[[.............<<....<<..<<.......>>..>.>....>>........<<<<<...<.....>...>>>>>[...((((((.......<<<<<<<<<<....>>>......<<......>>)))))).....]...<<<<..<<<.....>>>.>>>>....]]]...}}}}..]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<.....>>>..>>>.......]]].....<<<.<<<<<..>>>>>..>>>......<<<.<...........>>.>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]]]]............<<.......{{...[[[..{......<<<<.<....>.>>>>........<<<<<<.....>>>>>>...<<<<<.<<.......<<...<.......>..<<<.......>>>....>>......>>.>>..>>>.........[[[..(((((((.....>>>>>>>...))))))).]]].....}.....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<....>>>>>>>>>>>..>>>...<<..>>>>...>>.....>>>.....<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<...<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<..........<<.<<<........>>>.>>........>>>...<<.<<<..<<<<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<..<<<...<<..<<<<<<.<<<<<.......>>>>>.>..>>>>>..>>..>>>....<<<<<<.....>>>>>>........>>>>....>>>.>>>...>.>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<....<<<.<<<......>>>.>>>....>>.......>>>>>>>......<....<<<<<<..........>>>>>>....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<......<.<<.....>>.>......>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))((((.((((((...(((...(......(((.(((..((....(......(.......).....){))......(((.......(((..((..((....(((.............(......(...............).......)........(((((..(.......)..)))))(.(.(((((.........[[[[...((....)).......((......)).))))).)...).(.((((...(((..).))..)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).......(.(((...((((.}...))).))))).)....))).....((((.(((....))).).)).)...(.((.................))......)..((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......(.({{...(.(.((...(((..(......(((..(....)..)).).......(.((((.....)))).)....((((.((.......((..((.......)).(((.......)))....))......)).))..)).........((((..((((.(((.....].]]]...))).)))).)))..)..)....(((..((.((...((((..(((.((((((.(...((........))......).)))))).))).......((....))...))))..)).))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((....)))))))))))..)))...((..}}))...))...}.))))).).(((......((((....))))....)))...]]].](((((.(((((((..((...(((((..(((.((((((......((........))..........((((..(....(((.(........((.(((........))).))......).)))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....((((.((((...((..(((((...((...........)).....)))))..))..)))....((.(((.....))).)).......)))))....))).))).....).))))).....)..))))...)).)))).))).(...(((((((......((....(((.(.((....)).).)))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..(..(.((..(.(((((((..(((..(.((......((.(.....).))......)).)..)))..))))))))..)).)...)..).))...)..)..(((((((((....)))))))))>........ Translating S. pombe ribosome; 18S ribosomal RNA 9axv B2 3212 2.4 RF02540,RF02541,RF02543 39379376 0003735 0005840 4896 uugaccucaaaucagguaggacuacgcgcugaacuuaagcauaucaauaagcgcaggaaaagaaaauaaccaugauucccucaguaacggcgagugaagcgggaaaagcucaaauuugaaaucuggcaacauuucuuuuguuguccgaguuguaauuucaagaagcugcuuugaguguagacgaucggucuaaguuccuuggaacaggacgucagagagggugagaaccccgucuuuggucgauuggauaugccauauaaagcgcuuucgaagagucgaguuguuugggaaugcagcucuaaaugggugguaaauuucaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguagagugaucgaaagaugaaaagaacuuugaaaagagaguuaaauaguacgugaaauugcugaaagggaagcauuggaaaucagucuuaccugggugagaucaguagugcgagacuaugcacucugaaccugugguaggucagcaucaguuuucgggggcggaaaaagaauaagggaagguggcuuucggaguguuuauagcccuuguuguaauacguccacuggggacugaggacugcggcuucgugccaaggaugcugacauaaugguuuucaauggcccgucuugaaacacggaccaaggagucuagcaucuaugcgaguguuugggugaugaaaacccauccgcgaaaugaaagugaaugcaggugggaacgcccuuguggcgugcaccaucgaccgacccggaauggaaggguuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagagauucugacgugcaaaucgaucuucaaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaaacucagaucaguuuuaugagguaaagcgaaugauuagaggucuuggggaaggaauuuccucaaccuauucucaaacuuuaaauauguaagacgcccuugucgcuuaauuggacgugggccaucgaaugagaguuucuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacgugagguuaaggugccggaauguacgcucaucagacaccagaaaagguguuaguucaucuagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaugaacuagcccugaaaauggauggcgcuuaagcguacuacccauaccucaccgucuggguuaggagaagcucagacgaguaggcaggcguggagguuugugacgaagccuugggcgugagccugggucgaacagccucuagugcagaucuugguggaaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccaugugaacagcaguuggacauggguuagucgauccuaagagauagggaagcuccguaugaaaguugcacgauuuuucgugccuccuaucgaaagggaauccgguuaauauuccggaaccagaagguggaaucaacacggcaacguaaaugaaguuggagacgucggcgggagcccugggaagaguucucuuuucuuuuuaacaaaccauugaacuacccugaaaucgguuuauccggagcuaggguaugguguuuggaagaguucagcgccucaugcugaauccggugcgcucucgacggcccuugaaaauccaacggaagaauggccuuguuuucacaucuggucguacucauaaccgcagcaggucuccaaggugaacagccucuaguugauagaacaauguagauaagggaagucggcaaaauggauccguaacuucgggauaaggauuggcucuaaggguuggacaaccaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggccagaaagugguguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaacuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccuggggaacgggccaggcaaaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagaguuucuuuacuuaaucaaugaagcggaauugggauuuauuucccauauucuagcguuaaaguuucuucgcgaacugauccgcguugaugacauugucagguggggaguuuggcuggggcggcacaucuguuaaaagauaacgcagguguccuaagggggacucaucgagaacagaaaucucgaguagaauaaaaggguaaaaguccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuguucccucgaaauuugaggacagaggugccagaaaaguuaccacagggauaacuggcuuguggcagccaagcguucauagcgacguugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaagugucgucgcaaugguaauucaacuuaguacgagaggaaccguugauucagaucauugguauuugcggcugccugacaaggcaaugccgcggagcuaucaucugccggauaacggcugaacgccucuaagccagaauccgugccagaaagcgacgauuuuuugguccgcaugauuuauauguauaaaaauagagguaggacuuguuccuacucuccuguaucguagaagaugggcgaugguugaugaaacggaaguguuuuauugacuuguccaugaaauuccauugaaaucuugugcggaaucgaauccauugcauacgacuuuaauguggaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguucccaagauuugu 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........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.(((((((.......))))))).))....)........(((.(.(.(..(........(((.(.......(.((((......)))))[[(...).(((.....]])))......).)))...........)......).))..)))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((((((.......(...........................................)....((((((((((((((((((((((...........(((...........................)))..........))))).)))))))))).......................))))))).....)))))))))))).<((((........))))((((((....((((((.((((((..(((...((((.......))))...)))...((....)).......(((((..(((((.....)))))...))))).((((((((.........))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((.(....).)))))...)<)))...(((..((.((.......A)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((...(((.(((((((.....(((....(((..(.((((.....((((.....))))...)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))))))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((.............(.((....((.........))....)).......................)........)))))))))))..........]]].)....))))))))))...)))))))(((((((((........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((..(((((((...((.....)).))))))....[[(((.((...((....(((....)))............(..(......)..).......))....))...(((((........)))))]]((((......(.....((((....)))...(.[[((((((...((((.((((((((((((((((((...{{..))))))(...(((((........((((((.....(((.....))).....))))))....)))))....)((((.(((.....))).)))))))).).))))))).))))(...)....))))))...))..........).......)))).))).))).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.((((((.(.........)..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..(..((..............(........)..........)).....))))(.(((.........))).)........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.((((((((..((.((((...)))).))...(((((.....((((....(...........)...........]]...(..(......)..)...))))..))))).....))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......(..(...((((((...((.......))...))))))....)...)........((((.((((((..(.((((.(.......)..)))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a.))..))).)))))......(((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((....(((.............)))....)))).))))....)))))))............(((.........(.((................(..)...............))).......((((((...(((((((.((((......)))).))))))).))))))...................))).......(((((.(..(.......)..)...(.(((((((((.(((....(((([(..(((..(.....).)))].)))))...)))....)))).))))))..))))).. Translating S. pombe ribosome; 28S ribosomal RNA 9axv B3 119 2.4 RF00001 39379376 0003735 0005840 4896 gucuacggccauaccuaggcgaaaacaccaguucccguccgaucacugcaguuaagcgucugagggccucguuaguacuaugguuggagacaacaugggaauccggggugcuguaggcu <<<<<<<<<....<<<<<<<<.....<<<<<<............>>>>..>>....>>>>>>.>><<<<<<......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (.((((.((....((((((((.....((.(((...(....)...)))...))....)))))).))((((((......(((((..((....)).))))).....)))))))).)))).). Translating S. pombe ribosome; 5S ribosomal RNA 9axv B4 157 2.4 RF00002 39379376 0003735 0005840 4896 aaacuuucagcaacggaucucuuggcucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccuuuggguucuaccaaaggcaugccuguuugagugucauu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<......>>>>>>>>.................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))((((((((......)))))))).................... Translating S. pombe ribosome; 5.8S ribosomal RNA 9axv Sm 77 2.4 RF00005 39379376 0030533 4896 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((.(........)))).....(.(((..]....))).)))))))..... Translating S. pombe ribosome; tRNA 9axv Sn 75 2.4 RF00005 URS00021ED942_559292 39379376 0030533 0006412 4896 agcgccgugacgcaguggaagcgcgcagggcucauaacccugauguccucggaucgaaaccgagcggcgcuacca <<<<<<<...<<<.......>>>.<<<<<<.......>>>>>.>...<<<<<.......>>>>>>>>>>>>.... (((((((...(((....[..)))..(((((.......))))).....(((((..]....)))))))))))).... Translating S. pombe ribosome; A/P tRNA 9axv S3 10 2.4 39379376 4896 aauuuucuuu .......... .......... Translating S. pombe ribosome; mRNA 9b00 1A 2871 2.8 RF02541 39019034 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<........>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<...<......(..>....>>>.........<<......>>.).>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<...<<.......<<<<<<<....>>>>>>>....>>.............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<...>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((..(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...((((((((.(.((.(..........)..)))..))))))))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((..((.........))...))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........(((((...((.......((((.((....)).))))....)).............)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..(((...)))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with berberine analog of chloramphenicol CAM-BER, mRNA, deacylated A- and E-site tRNAphe, and deacylated P-site tRNAmet at 2.80A resolution; 23S Ribosomal RNA 9b00 1B 120 2.8 RF00001 39019034 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((....)))))))).......))..)))))))))). Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with berberine analog of chloramphenicol CAM-BER, mRNA, deacylated A- and E-site tRNAphe, and deacylated P-site tRNAmet at 2.80A resolution; 5S Ribosomal RNA 9b00 1a 1500 2.8 RF00177,RF01959,RF02542,RF01960 39019034 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<......>>....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((..)))))))).)))))......(((......((((((((..((...(((((((.((((......(((((....)))).)......))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((((((....)))))))....(((....)))....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with berberine analog of chloramphenicol CAM-BER, mRNA, deacylated A- and E-site tRNAphe, and deacylated P-site tRNAmet at 2.80A resolution; 16S Ribosomal RNA 9b00 1v 13 2.8 39019034 10665 aaaaauguucuaa ............. ............. Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with berberine analog of chloramphenicol CAM-BER, mRNA, deacylated A- and E-site tRNAphe, and deacylated P-site tRNAmet at 2.80A resolution; MF-mRNA 9b00 1w 74 2.8 RF00005 39019034 0030533 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[..)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with berberine analog of chloramphenicol CAM-BER, mRNA, deacylated A- and E-site tRNAphe, and deacylated P-site tRNAmet at 2.80A resolution; A-site and E-site Deacylated tRNAphe 9b00 1x 76 2.8 RF00005 39019034 0030533 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with berberine analog of chloramphenicol CAM-BER, mRNA, deacylated A- and E-site tRNAphe, and deacylated P-site tRNAmet at 2.80A resolution; P-site Deacylated tRNAmet 9b00 1y 74 2.8 RF00005 39019034 0030533 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((......)))).((((.........)))).....(((((.......)))))))))))).... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with berberine analog of chloramphenicol CAM-BER, mRNA, deacylated A- and E-site tRNAphe, and deacylated P-site tRNAmet at 2.80A resolution; A-site and E-site Deacylated tRNAphe 9b00 2A 2800 2.8 RF02541 39019034 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<<....<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<....<<<..........>>.>....>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<..>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>......>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<...>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((...))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((..))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((.....((..........)..)....)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((((((()))))))))).))..........]]].)....))))))))))...)))))))(((((((..)))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(......[..(((((..((........(((((((....))))))).....))..........].)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.((((...........))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..((((((((........)))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(((...)).....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))...)))) Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with berberine analog of chloramphenicol CAM-BER, mRNA, deacylated A- and E-site tRNAphe, and deacylated P-site tRNAmet at 2.80A resolution; 23S Ribosomal RNA 9b00 2B 120 2.8 RF00001 39019034 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>. .((((((((((....((((((.(....(((((((...(.....)...))))..)))...).)))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with berberine analog of chloramphenicol CAM-BER, mRNA, deacylated A- and E-site tRNAphe, and deacylated P-site tRNAmet at 2.80A resolution; 5S Ribosomal RNA 9b00 2a 1503 2.8 RF00177,RF01959,RF02542,RF01960 39019034 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggau .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<......>>....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<..<.<<<<<<<........>>>>>>>>...>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(.(((....)))..))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((.(((((......((........))..........(((((((..(...(((((((...(((((((....)))))))....(.(....).)....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).))).)))).(...(((((((.....(((..(((.(.((....)).)).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with berberine analog of chloramphenicol CAM-BER, mRNA, deacylated A- and E-site tRNAphe, and deacylated P-site tRNAmet at 2.80A resolution; 16S Ribosomal RNA 9b00 2v 13 2.8 39019034 10665 aaaaauguucuaa ............. ............. Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with berberine analog of chloramphenicol CAM-BER, mRNA, deacylated A- and E-site tRNAphe, and deacylated P-site tRNAmet at 2.80A resolution; MF-mRNA 9b00 2w 72 2.8 RF00005 URS00005AA258_562 39019034 0030533 0006412 562 cccgganagcucagggagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<..<<<<.....>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((...[.)))).((((.........)))).....(((((..]....)))))))))))..... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with berberine analog of chloramphenicol CAM-BER, mRNA, deacylated A- and E-site tRNAphe, and deacylated P-site tRNAmet at 2.80A resolution; A-site and E-site Deacylated tRNAphe 9b00 2x 76 2.8 RF00005 39019034 0030533 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaacca <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with berberine analog of chloramphenicol CAM-BER, mRNA, deacylated A- and E-site tRNAphe, and deacylated P-site tRNAmet at 2.80A resolution; P-site Deacylated tRNAmet 9b00 2y 73 2.8 RF00005 39019034 0030533 562 gcccgganagcucagggagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<.....>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[.)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with berberine analog of chloramphenicol CAM-BER, mRNA, deacylated A- and E-site tRNAphe, and deacylated P-site tRNAmet at 2.80A resolution; A-site and E-site Deacylated tRNAphe 9bdl A18S 1691 2.8 RF01960,RF02542,RF01959,RF00177 URS0000EEACFB_9986 38718836 0003735 0005840 9986 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucgacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgcggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcggccguccccugcucggcgccggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgaccccggucggcguaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccgggccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<....<<....<<<..........<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<<<....>>>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<.>>>>>>>....>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....<<<<<<<<<.<<<....>>>..>>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<....<<<.<<<..>>>.>>><<<<<<<.<<..>>>>>>.>>>.<<<<<<.<.......<<...<.......>.<<<<.>>>>...>>......>.>>>..>>>........<.<<.<<<<<<<...............>>>>>>>.>>.>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<<.......<<.<<<........>>>.>>.....>>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<..>>>>.>>>>>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>>....>.>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>............<<<<<..........>>>>>...........>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<<<<<<<<<..>>>>>>>.>.>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..((....(((.....((...((.....((.(((.....))).))......))......)).((((...((((((....))))))...))))((..(((((...(......)..)))))......)).(.((((..((.)).)))))...)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).).....(((((((((.(((....)))..)))))).)))....(.((..(...........)..))......)..((((([[......((((.....((..]])).......)))).)))))..)))))).)))..[......(.([[...(.(.((...(((..(....(((..((()))..))).((((((.((())))))).))..((((((.(.......((..((.......)).(((.)))....))......).)))..)))........(.((.(((((((...............))))))).)).)....)....(((..(...(...((((..((..((((((((...((........))......))))))))..)).......((....))...))))..)...)...))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.(((((....))))))))))).)..)))...((..]]))...))...].))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((..((........))..))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((...(...((((..((((((((((((..)))).))))))))..))))..).....(((((.....)))))........)))....))).))).....).))))).....).)))))...)).)))).))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....((.(((((.......))))).))......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..((((.((...(((((((((((.(()).))))).).)))))...)).))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}........ 80S ribosome with angiogenin; 18S rRNA 9bdl A28S 3557 2.8 RF02543 38718836 0003735 0005840 9986 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggaaauguggcguacggaagacccacuccccggcgcgggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcgcgguccggccgugccggcggggcggauccccgcucucggcgggggaccgccccccggccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggccccggcggggaagguggcccgggggccccggguguuacagccccgccccggcagcagcagcucgccgaaucccggggccgagggagcgagacccgugcgccgcgcucuccccccggggggccgggccaccccucccacggcgcgaccgcuggggcggacuguccagugcgccccgggcgggucgcgccgucgggcccggggggccacgcguccagcgcacggggucggcggcgaugucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcuacgaaagccgccguggcgcaaugaaggugaaggccggccggccgaggugggaucccgaggccuuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcgaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccaaaguuucccucaggauagcuggcgcucuccgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcugguguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggaugguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgcuggcagucggcagagcgagaaagagagggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucagccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcucagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacaugagagguguagaauaagugggaggccggccgccggugaaauaccacuacucugaucguuuuuucacugacccggugaggcgggggggcgagggcucucgcuucuggcgccaagcgcccggcgccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauagccggagccucgguuggccucggauagccggucccccggggguccggugcggagagcccuucgucccgggaaacggggcggccggaaagggggccgcccucucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcaggcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..[[[..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>>..<<<<<<<<<....<<<<<<<.<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>....>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<......>>>..................................<<<<<<<<..<<<.<....<<<<<<<<.<<<.....<<<<<<<<<<....<<<<<<<.<<<<<.<<<<<<<.<<<<<<<<...>>>>>>.>>>>>>>>>>>>>>>>>>...>>>.>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<.<<<<<<<<<<.<<<<...<<..<<<..<<<<<<<......<<<<<<<...>>>>>>>.......>>>>>>>..>>>.........>>>>>>...>>>>>>>>>>.....<<.......>>.........<...<<<<...>>>>...<.<<...<<.<<<<<<<<<<<<<<<<<<<<<<<.<<<<..>>>>.>>>>>>.>>>>.>>>>>>>>>>.>>>...>>.>>.>..........>.........>>.>>>>>....>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<.....>>>>.....>>>...<<....>>...<<<<<..>>>>>..<<<<<...<<<..<<<.......[[.>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<...<<<.<<<<<<<<<...<<<....<<<..<.<<<..<<<<.<.........>.>>>>>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.........>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<........<<<<<.<<.....................>>......................>>>>>....>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<....................]]..........>>>>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<<<<<...>>>>>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<..<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..{{{..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<...............>>>>><<.<<<<<<<<<<.>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<<.<<<<<<<<<<<<.<<<<..........<<<<<..<<<..>>>............>>>>>.>>>>.>>.>>>>>>>>>>...<<<<<.....<<<<..<<.<<....>>>>..............<<<<<<<<..>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>><<<<....>>>>>>)))]......((((((..(((..>>>>>>.)))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]].....<<<<<<.<..<<<....<<<<<.................>>>>>..<<<<....<<<<....<<.<<<<<<<}}}.>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.<<<<<..<<<<....<<<........<<<<<..<<<<.>>>>.>>>>>.......>>>...<<<..<<<<......<<<<<<<........>>>>>>.>.....>>>>..>>>..............>>>>..>>.>>>...<<<<<....................<<.<<<<<<<.<<.....<<<<.<..<<<<.>>>>..>>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..(((((((((((.....)))))).))))....))))....(((((((((....((((((((((((((((..({((((......)))))....[[(...).(((....}]])))...).)))))))...))))))))...)))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((..(...((((((((.(((.....((((((((((.(..(((((((.(((((.(((((((.(((((((.(..)))))).))))))))))))))))))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((..(((((((......(((((((...))))))).......)))))))..))).........))))))..))))))))))).....((.....{.)).........(...(((((.)))))...(.((..(((.(((((((((((((((((((((((.((((..)))).)))))).))).))))))))))).)))...))))).)..........)........))).)))))...).)))...)))))))).[((((........))))((((((....(((((((((((((..(((..(((((.....))))..)..)))...((....))...(((((())))))..(((((...(((..(((.......[[[)))..)))....))))).(((((((((.((((......))))))))))).))....)))))))))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((...(((.((((((((....(((....(((..(.(((..(((.((.(.....)..)))))))).)..)))..)).)....))))))...(((((((((.(......))))))))))....))))))))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.......(((((..((...................))......(..............).)))))...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((........}.........].]]..........)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...((..(.(((....))).....)....((.(((((((((...)))))))))))......))....))...(((((........)))))]]((((....(((((...((.((((....)))).))..((((....)))...(...((((((...(((((((((((((((((((((((...{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.((((((((((.))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(..(((.....((((....)))).....))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.(((((((((.((((((((...(.(((............((((..((.(.)))............))))...))).)....))))))))...(((((.....((((..(..(((..))).)..............((((((((()))))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a.))..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}..)))))..)).))...))))...)))).((((...((((.............))))...))))..)))...).)))))).(((((..((((....(((.........((((.(.(((.)))).))))........)))...(((..(((.....((..(((((........)))))...))....)))..)))..............))))..).))))...(((((.(..(.......)..)....((.(((((((.((.....((((.(..((((.))))..)))))....))....)))).))).))..))))).. 80S ribosome with angiogenin; 28S rRNA 9bdl A58S 151 2.8 RF00002,RF02540 38718836 0003735 0005840 9986 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcagguugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<<<<....>>>>.....<.<<<......>>........>>>..>...>>>....<<<..>>><<<<<<<<.......>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]]........)))..)...)))....((....))((((((((.......)))))))).................... 80S ribosome with angiogenin; 5.8S rRNA 9bdl A5S 120 2.8 RF00001 38718836 0003735 0005840 9986 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. 80S ribosome with angiogenin; 5S rRNA 9bdl ETRN 77 2.8 RF00005 38718836 0030533 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(.(((.......))).)))))))..... 80S ribosome with angiogenin; tRNAfMet 9bdl MRNA 10 2.8 URS00023359A7_4932 38718836 9986 cacauguucc .......... .......... 80S ribosome with angiogenin; Model mRNA 9bdl PTRN 77 2.8 RF00005 38718836 0030533 83333 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... 80S ribosome with angiogenin; tRNAfMet 9bdn A18S 1691 3.1 RF01960,RF02542,RF01959,RF00177 URS0000EEACFB_9986 38718836 0003735 0005840 9986 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucgacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgcggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcggccguccccugcucggcgccggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgaccccggucggcguaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccgggccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<....<<....<<<<<........<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<<<....>>>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<.>>>>>>>.>>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....<<<<<<<<<.<<<....>>>..>>>>>>.>>>......<<..<...........>..>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<....<<<.<<<..>>>.>>><<<<<<<.<<..>>>>>>.>>>.<<<<<<.<.......<<...<.......>.<<<<.>>>>...>>......>.>>>..>>>........<.<<.<<<<<<<...............>>>>>>>.>>.>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<<....>>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<........<<........>>..........<<<<<......<<<<<<.......<<.<<<........>>>.>>.....>>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<..>>>>.>>>>>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>>......>>>>>......>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<<<<<<<<<..>>>>>>>.>.>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..((....(((..........((.....((.(((.....))).))......))..........(((...((((((....))))))...))).((..(((((...(......)..)))))......)).(.((((..((.)).)))))...)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).).....(((((((((..((....))...)))))).)))....(.((..(...........)..))......)..((((([[......((((.....((..]])).......)))).)))))..)))))).)))..[......(.([[...(.(.((...(((.((....(.(.(((())))..)).((((.(.((()))).)).))..((((((.(.......((..((.......)).(((.)))....))......).)))..)))........(.((.(.((((.................)))).).)).)....))...(((.((...(...((((..((..((((((((...((........))......))))))))..)).......((....))...))))..)...))..))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.(((((....))))))))))).)..)))...((..]]))...))...].))))).).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....((((......(..((..(..........)..))....)..))))...((.(((...(.((((((.(..(((.(((((....)))..(.((......)))...)).)))....(((...(...((((..(((.((((((((..)))).)))).)))..))))..).....(((((.....)))))........))).)..))).))).....).))))).....).)))))...)).)))).))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(..((((.((..(.((((((((.(((..((((.((...(((((.(((((.(()).)))))...)))))...)).))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}........ 80S ribosome with angiogenin and tRNAAla; 18S rRNA 9bdn A28S 3557 3.1 RF02543 38718836 0003735 0005840 9986 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggaaauguggcguacggaagacccacuccccggcgcgggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcgcgguccggccgugccggcggggcggauccccgcucucggcgggggaccgccccccggccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggccccggcggggaagguggcccgggggccccggguguuacagccccgccccggcagcagcagcucgccgaaucccggggccgagggagcgagacccgugcgccgcgcucuccccccggggggccgggccaccccucccacggcgcgaccgcuggggcggacuguccagugcgccccgggcgggucgcgccgucgggcccggggggccacgcguccagcgcacggggucggcggcgaugucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcuacgaaagccgccguggcgcaaugaaggugaaggccggccggccgaggugggaucccgaggccuuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcgaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccaaaguuucccucaggauagcuggcgcucuccgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcugguguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggaugguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgcuggcagucggcagagcgagaaagagagggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucagccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcucagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacaugagagguguagaauaagugggaggccggccgccggugaaauaccacuacucugaucguuuuuucacugacccggugaggcgggggggcgagggcucucgcuucuggcgccaagcgcccggcgccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauagccggagccucgguuggccucggauagccggucccccggggguccggugcggagagcccuucgucccgggaaacggggcggccggaaagggggccgcccucucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcaggcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<.<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>.>..<<<<<<<<<....<<<<<<<.<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>....>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<.<....<<<<<<<<.<<<.....<<<<<<<<<<....<<<<<<<.<<<<<.<<<<<<<.<<<<<<<.....>>>>>.>>>>>>>>>>>>>>>>>>...>>>.>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<<<<<<<<<<<<.<<<<...<<..<<<..<<<<<<<......<<<<<<<...>>>>>>>.......>>>>>>>..>>>.........>>>>>>...>>>>>>>>>>.....<<.......>>.........<...<<<<...>>>>...<.<...<<<.<<<<<<<<<<<<<<<<<<<<<<<.<<<<..>>>>.>>>>>>.>>>>.>>>>>>>>>>.>>>...>>>.>.>..........>........>>>.>>>>>....>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<.....>>>>.....>>>...<<....>>...<<<<<..>>>>>..<<<<<...<<<..<<<.......[[.>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<...<<<.<<<<<<<<<...<<<....<<<....<<<..<<<<.............>>>>>>>....>>>..>>.>...>>>>>>>...<<<<<<<<<.........>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<........<<<<<...................................<<......>>...>>>>>....>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<....................]]..........>>>>>>>>>....>>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<<<<<...>>>>>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<..<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<.<<<<<<<<<<.>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<<<<<<.<<<<...........<......<<..>>................>..>>>>.>>.>>>>>>>>>>...<<<<<.....<<<<..<<.........>>..............<<<<<<<<..>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>>.<<<....>>>.>>)))].....<<<<<<<..<<<..)))))).>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<....<<<<<.................>>>>>..<<<<....<<<<....<<.<<<<<<.]]]..>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.<<<<<..<<<<....<<<........<<<<<..<<<<.>>>>.>>>>>.......>>>...<<<..<<<<.......<<<<<<........>>>>>.>......>>>>..>>>..............>>>>..>.>>>>...<<<<<....................<<.<<<<<<<.<<.....<<<<.<..<<<<.>>>>..>>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..(((((((((((.....)))))).))))....))))....(((((((((....((((((((((((((((..({((((......)))))....[[(...).(((....}]])))...).)))))))...))))))))...)))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((..(...((((((((.(((.....((((((((((.(..(((((((...(((.(.((.((.((((((.......)))).)))).)).))))..))))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((..(((((((......(((((((...))))))).......)))))))..))).........))))))..))))))))))).....((.....{.)).............(((((.)))))...(.((..(((.(((((((((((((((((((((((.((((..)))).)))))).))).))))))))))).)))...))))).)...................))).)))))...).)))...)))))))).[((((........))))((((((....(((((((((((((..(((..(((((.....))))..)..)))...((....))...(((((())))))..(((((...(((..(((.......[[[)))..)))....))))).(((((((((.((((......))))))))))).))....)))))))))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)<)))...(((..((.((.......B)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((...(((.((((((((....(((....(((..(.(((..(((..(.(.....)..).)))))).)..)))..)).)....))))))...(((((((((.(......))))))))))....))))))))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.....A.((.((...(...................)...........(.........)..)).))...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((........}.........].]]..........)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...((..(.(((....))).....)....(..((((((.((...)).)))))).)......))....))...(((((........)))))]]((((....(((((...((.((((....)))).))..((((....)))...(...((((((...(((((((((((((((((((((((...{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.((((((((((.))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(..(((.....((((....)))).....))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.(((((((((.((((((((...(.((.............(.((..(((..)))............)).)....)).)....))))))))...(((((.....((((......(....).................(((((((....)))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..b.))..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}..)))))..)).))...))))...)))).((((...((((.....a.......))))...))))..)))...).)))))).(((((..((((....(((.........((((...(((.)))..))))........)))...(((..(((.....(((.(((((........)))))..)))....)))..)))..............))))..).))))...(((((.(..(.......)..)....((.(((((((.((.....((((.(..((((.))))..)))))....))....)))).))).))..))))).. 80S ribosome with angiogenin and tRNAAla; 28S rRNA 9bdn A58S 151 3.1 RF00002,RF02540 38718836 0003735 0005840 9986 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcagguugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<<<<....>>>>.....<.<<<......>>........>>>..>...>>>....<<<..>>><<<<<<<<.......>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]]........)))..)...)))....((....))((((((((.......)))))))).................... 80S ribosome with angiogenin and tRNAAla; 5.8S rRNA 9bdn A5S 120 3.1 RF00001 38718836 0003735 0005840 9986 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. 80S ribosome with angiogenin and tRNAAla; 5S rRNA 9bdn ETRN 77 3.1 RF00005 38718836 0030533 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........))))..((((.......))))......(((((.......)))))))))))..... 80S ribosome with angiogenin and tRNAAla; tRNAfMet 9bdn MRNA 10 3.1 URS00023359A7_4932 38718836 9606 cacauguucc .......... .......... 80S ribosome with angiogenin and tRNAAla; mRNA 9bdn PTRN 77 3.1 RF00005 38718836 0030533 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(((((.......)))))))))))..... 80S ribosome with angiogenin and tRNAAla; tRNAfMet 9bdn TIRN 71 3.1 RF00005 38718836 0030533 4932 gggcguguggcguagucgguagcgcgcucccuugggagaggucuccgguucgauuccggacucguccacca <<<<<....<<<<........>>>>.<<<<<..>>>>>.....<<<<<.......>>>>>..>>>>>.... (((((.(..((((.....[..)))).(((((..))))).....(((((..]....)))))).))))).... 80S ribosome with angiogenin and tRNAAla; tRNAAla 9bdp A18S 1691 3.7 RF01960,RF02542,RF01959,RF00177 URS0000EEACFB_9986 38718836 0003735 0005840 9986 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucgacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgcggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcggccguccccugcucggcgccggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgaccccggucggcguaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccgggccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<.....<<..........>>....>.>>......<<........<<<.<....<<....<<<..........<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<<<....>>>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<..<<.>>.>>>>....>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....<<<<<<<<<.<<<....>>>..>>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<.....<<.<<<..>>>.>>.<<<<<<<.<<..>>>>>>.>>>.<<<<<<.<.......<<...<.......>.<<<<.>>>>...>>......>.>>>..>>>........<.<<.<<<<<<<...............>>>>>>>.>>.>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<......<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<......>>...<<<......>>>...>>.>>>....<<<...<...<<<...<<<<<<<<<<<<..>>>>.>>>>>>>>...>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.......>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>............<<<<<..........>>>>>...........>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<.<<<<<<<..>>>>>>>...>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>.........<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))(((.((((((...(.((..((.....(((.(((..((....((....((..........))...))[))......(((.......(((.(.(..((....(((..........((.....((.(((.....))).))......)).........((((...((((((....))))))...))))((..(((((...(......)..)))))......))...((((..((.)).))))....)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).).....(((((((((.(((....)))..)))))).)))....(.....(...........)..........)..((((([[......((((.....((..]])).......)))).)))))..)))))).)))..[......(..[[...(.(.((...(((.((....(((.(((()))).)))...((((.((()))))))......(((((.........((..((.......)).((.()))....))........)))..))...........((.(((((((...............))))))).))......))...((..(((..(...((((..((..((((((((...((........))......))))))))..)).......((....))...))))..)..)))...)..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.(((((....))))))))))).)..)))...((..]]))...))...].))))..).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((......(((((.....(..((..(..........)..))....).)))))...((.(((...(.((((((.(..(((.(((((....)))..(.((......)))...)).)))....(((...(...((.(..((((((((((((..)))).))))))))..).))..).....(((((.....)))))........))).)..))).))).....).))))).......)))))...)).)))).))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....((.(((((.......))))).))......))...)))))))))).))..(....((.(..((((.((..(.((((((((.(((..((((.((...(((((((((((.(()).))))).).)))))...)).))))..))).)))))))))..)).))))...).))......)..((((((((......))))))))}........ 80S ribosome bound with angiogenin and complex of eEF1A and Ala-tRNAAla; 18S rRNA 9bdp A28S 3557 3.7 RF02543 38718836 0003735 0005840 9986 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggaaauguggcguacggaagacccacuccccggcgcgggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcgcgguccggccgugccggcggggcggauccccgcucucggcgggggaccgccccccggccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggccccggcggggaagguggcccgggggccccggguguuacagccccgccccggcagcagcagcucgccgaaucccggggccgagggagcgagacccgugcgccgcgcucuccccccggggggccgggccaccccucccacggcgcgaccgcuggggcggacuguccagugcgccccgggcgggucgcgccgucgggcccggggggccacgcguccagcgcacggggucggcggcgaugucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcuacgaaagccgccguggcgcaaugaaggugaaggccggccggccgaggugggaucccgaggccuuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcgaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccaaaguuucccucaggauagcuggcgcucuccgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcugguguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggaugguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgcuggcagucggcagagcgagaaagagagggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucagccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcucagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagagacaugagagguguagaauaagugggaggccggccgccggugaaauaccacuacucugaucguuuuuucacugacccggugaggcgggggggcgagggcucucgcuucuggcgccaagcgcccggcgccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauagccggagccucgguuggccucggauagccggucccccggggguccggugcggagagcccuucgucccgggaaacggggcggccggaaagggggccgcccucucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcaggcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<...<<<<...<<<<<<<<<<<...>>>>>>>.>>>>.....>>>>...<<<<<<<<<....<<<<<<<.<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>....>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..(((((.>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<<<<..<<<.<....<<<<<<<<.<<<.....<<<<<<<<<<....<<<<<<<.<<<<<.<<<<<<<.<<<<<<<<...>>>>>>.>>>>>>>>>>>>>>>>>>...>>>.>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<<<<<<<<<<<<.<<<<...<<..<<<..<<<<<<<......<<<<<<<...>>>>>>>.......>>>>>>>..>>>.........>>>>>>...>>>>>>>>>>.....<<.......>>.........<...<<<<...>>>>....<<....<<.<<<<<<<<<<<<<<<<<<<<<<<.<<<<..>>>>.>>>>>>.>>>.>>>>>>>>>>>.>>>...>>...>>..........>........>>>.>>>>>....>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<.....>>>>.....>>>...<<....>>...<<<<<..>>>>>..<<<<<...<<<..<<<.......[[.>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<...<<<.<<<<<<<<<...<<<....<<<....<<<..<<<<.<.........>.>>>>>>>....>>>..>.>>...>>>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<........<<<<<.<<.....<..........>....>>.........<........>...>>>>>....>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<....................]]..........>>>>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<<....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<<<<<...>>>>>>>>>>>......>>....>>...<<<<<........>>>>>))<<<<....<<<<<..<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<<<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>.>.>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<...............<<<<<.....<..>......>>>>><<.<<<<<<<<<<.>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>...>>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<<<<<<.<<<<...........<<<<...<<..>>.............>>>>..>>>>.>>.>>>>>>>>>>...<<<<<.....<<<<..<<.........>>..............<<<<<<<<..>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>>.<<<....>>>.>>)))]......<<<<<<..<<<...))))).>>>>>>>>>..........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<]]].>>>>>..>>.>>...>>>>...>>>><<<<....<<<<<...........>>>>>....>>>>.>>>...>.>>>>>>.<<<<<..<<<<....<<<........<<<<<..<<<<.>>>>.>>>>>.......>>>...<<<..<<<<....<...<<<<<........>>>>>....>...>>>>..>>>..............>>>>..>.>>>>...<<<<<....................<<.<<<<<<<.<<.....<<<<....<<<<.>>>>...>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..(((((((((((.....)))))).))))....))))....(((((((((....((((.(((((((((((..({((((......)))))....[[(...).(((....}]])))...).)))))))...))).))))...)))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((..(...((((((((.(((.....((((((((((.(..(((((((.(((((.(((((((.(((((((.....))))).))))))))))))))))))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((..(((((((.......((((((...))))))........)))))))..))).........))))))..))))))))))).....((.....{.)).......(.....(((((.)))))...(.((...((.(((((((((((((((((((((((.((((..)))).)))))).))).))))))))))).)))...).)).)).............).....))).)))))...).)))...)))))))).[((((........))))((((((....(((((((((((((..(((..(((((.....))))..)..)))...((....))...(..((()))..)..(((((...(((..(((.......[[[)))..)))....))))).(((((((((.((((......))))))))))).))....)))))))))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((...(((.((((((((....(((....(((...((((..(((..(..........).)))))).)..)))..)).)....))))))...(((((((((.(......))))))))))....))))))))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.(((((((((........(((((.(((....(..........)...))).....(...((......)).).)))))....))))))))))))..........]]].)....))))))))))...)))))))((((((.(((........}.........].]]..........)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...(.......).))))))....[[(((.((...((....(((....)))..........(..((((.((((...)))).)))).)......))....))...(((((........)))))]]((((....(((((...((.((((....)))).))..((((....)))...(...((((((...((((((((((((((((((((((....{{...)))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.((((((((((.))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.(..(((.....((((....)))).....))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.(((((((((.(((((.((..((.(((.............(....(((..)))..............)....))).))...)).)))))...(((((.....((((.....((....))................(.((((((())))))).)..))))..)))))....)))))))))..)))))..(((......[)).)((((............]..))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(.((((........))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a.))..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}..)))))..)).))...))))...)))).((((...((((.............))))...))))..)))...).)))))).(((((..((((....(((.........((((.(.(((.)))).))))........)))...(((..(((.....(...(((((........)))))....)....)))..)))..............))))..)).)))...(((((.(..(.......)..)....((.(((((((.((.....((((.(..((((.))))..)))))....))....)))).))).))..))))).. 80S ribosome bound with angiogenin and complex of eEF1A and Ala-tRNAAla; 28S rRNA 9bdp A58S 151 3.7 RF00002,RF02540 38718836 0003735 0005840 9986 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcagguugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<.<<.....>>>.....(.<<<......>>........>>>..)...>>>....<<<..>>><<<<<<<<.......>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]]........)))..)...)))....((....)).((((((.........))))))..................... 80S ribosome bound with angiogenin and complex of eEF1A and Ala-tRNAAla; 5.8S rRNA 9bdp A5S 120 3.7 RF00001 38718836 0003735 0005840 9986 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. 80S ribosome bound with angiogenin and complex of eEF1A and Ala-tRNAAla; 5S rRNA 9bdp ETRN 77 3.7 RF00005 38718836 0030533 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(.(((.......))).)))))))..... 80S ribosome bound with angiogenin and complex of eEF1A and Ala-tRNAAla; tRNAfMet 9bdp MRNA 10 3.7 URS00023359A7_4932 38718836 9606 cacauguucc .......... .......... 80S ribosome bound with angiogenin and complex of eEF1A and Ala-tRNAAla; mRNA 9bdp PTRN 77 3.7 RF00005 38718836 0030533 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ..(((((..((((.........)))).(((((.......))))).....(((((.......))))))))))...... 80S ribosome bound with angiogenin and complex of eEF1A and Ala-tRNAAla; tRNAfMet 9bdp TIRN 70 3.7 RF00005 38718836 0030533 4932 gggcguguggcguagucgguagcgcgcucccugggagaggucuccgguucgauuccggacucguccacca <<<<<....<<<<........>>>>.<<<<<.>>>>>.....<<<<<.......>>>>>..>>>>>.... (((((.(..((((.....[..)))).(((((.))))).....(((((..]....)))))).))))).... 80S ribosome bound with angiogenin and complex of eEF1A and Ala-tRNAAla; tRNAAla 9bh5 A7 119 2.63 RF00001 39209556 0003735 0005840 6239 gcuuacgaccauaucacguugaaugcacgccaucccguccgaucuggcaaguuaagcaacguugaguccaguuaguacuuggaucggagacggccugggaauccuggauguuguaagcu <<<<<<<<<....<<<<<<<<.....<<<<<<............>>>>..>>....>>>>>>.>><<<<<<......<<.<<..<<....>>.>>.>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))). High-resolution C. elegans 80S ribosome structure - class 1; 5S rRNA 9bh5 A8 146 2.63 RF00002 39209556 0003735 0005840 6239 uagcuucagcgauggaucgguugcaucgaguaucgaugaagaacgcagcuugcugcguuacuuaccacgaauugcagagaguggugaaauuucgaacgcauagcaccaacugggccuccaguugguacgucugguucaggguuguu ........................................<<<<<<.((.....>>>.....<<<<<<.....)).....>>>>>.>...>>>....<<...>><<<<<<<<<....>>>>>>>>>.................... ........................................((((((.[[.....))).....(.((((.....]].....))))..)...)))....((...))(((((((((....))))))))).................... High-resolution C. elegans 80S ribosome structure - class 1; 5.8S rRNA 9bh5 B2 1476 2.63 RF01960,RF02542,RF01959,RF00177 39209556 0003735 0005840 6239 uaccugauugauucugucagcgcgauaugcucaaguaaaagauuaagccaugcaugcgauucauugaaauugcguacggcucauuagagcagauaucaccuuauccgggauggauaacugcggaaauacuggagcuaauacaugcaccccagcggggugcaauuauuaguguugacucugaauaaagcaguuuacugucagcugacucuauccggaaagggugucugcccuuucaacuagaugguaguuuauuggacuaccaugguuguuacggguaacggagaauaaggguucgacuccggagagggagccuuagaaacggcuaccacguccaaggaaggcagcaggcgcgaaacuuauccacuguuguaugagauagugacuaaaaauauaguugaauacaaaugauucuucgaggagagggcaagucuggugccagcagccgcgguaauuccagcucuccuaguguaucucguuauugcugcgguuaaaaagcucguaguuggaucuagguuuaccuugaauaaaucagagugcucaauacaagcgcuugcuugaauagcaucauggaauaaugaaauuaaugguuaagagggacaaaccgggggcauucguaucauuacgcgagaggugaaauucguggaccguagugagacgcccaacagcgaaagcauuugccaagaaugucuucauuaaucaagaacgaaagucagagguucgaaggcgauuagauaccgcccuaguucugaccguaaacgaugccaucucgcgauucggagggugcccugccgaggagcauccggaaacgaaagucuuucgguuccggggguaguaugguugcaaagcugaaacuuaaagaaauugacggaagggcaccacaaggcguggagcuugcggcuuaauuugacucaacacgggaaaacucacccgguccggacaccaugacugacagauugaaagcucuuucucgauuuggugguugguggugcauggccguucuuaguugguggagugauuugucugguuuauuccgauaacgagcgagacucuagccucuaaauaguuggcgaaucuucggguucguuaacuucuuagagggauaagcgguguuuagccgcacgagauugagcgauaacaggucugugaugcccuuagauguccggggcugcacgcgugcuacacugguggagucagcggguccuaugccgaaagguaucgguaaaccguugaaauucuuccauguccgggauaggguauuguaauuauugcccuuaaacgaggaaugccuaguaagugugagucaucagcucacguugauuacgucccugcccuuuguacacaccgcccgucgcuauccgggacugaacugauucgagaagaguggggacugugcggaaaccauuuuuaucgcauugguuugaaccggguaaaagucguaacaagguagcuguaggugaaccugcagcuggaucaucg ...<<<<<.[.((((>>>>><<.<<<<<<<.....<<..<......<<<.<<<..<<<<<<......>>>>>>......<<.......<<<<<<<<..<<<..<<<<<<.<<.....<<.<<<.....>>>.>>......>>...<<<<<...>>>>><<..<<<<<...<......>..>>>>>....>>.....<<<<..>>>>....>>>>>>.>>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<.....>..>>>..>...>>........<..<<<<.......>>>>..>..<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>>.>>.........<<<((.....<.<<...<<<.<<.......<<<<<.<<<.......<..<<.......>>.<<<....>>>....>....>>>.>>..>>>............>>....<<<<<<...<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<..<..<<..<<<<<<<<<..>>>>.>>>>>..>>...<<..))>>...>......>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<.......<<........>>..........<<<<<.<....<<<<<.....<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<<<<<<<..<<<<<<<<<<<<....>>>>>>>>>>>>..>>>>>>>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.....>.>>>>>....>.>>>>.>>>.....<<.<<<<......<<.<<.<<<<<....>>>>>.>>....>>.......>>>>.>>......<....<<<<<<..........>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<<<<....<<<<<<<<.<<<.<<<<<<<<...<<<..>>>...>>>>>>>>.>>>.>>>>>>>>...>>>>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))((.(((((((.....((..((.....(((.(((..(((((........)))))......(((.......((((((...(((..((((((.((.....((.(((.....))).))......))...(((((...)))))((..(((((...(......)..)))))....)).....((((()))))....)))))).))).)))))).(((....(((..((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((....((...))..)))).)...))........(..(((.........)))..)..((((([[....(.((((.....((..]])).......))))))))))..))))))).))..[......((([[...(.(.((...(((..(.......(((((.(((.......(..((.......))...(....)......)....))).))..)))............)....(((..((...(...((((..((..((((((((...((........))......))))))))..)).......((....))...))))..)..))...))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((..(..((..(((((((((())))).)))))..))...((..]]))...)....].))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....((.(((........))).))......)))))...((.(((...(.((((((....(((.(((((....)))....((......))....)).)))....(((...(((((((..(((((((((((......)))))))))))..))))))).....(((((.....)))))........)))....))).))).....).))))).....).)))))...)).)))).))).(...((.(((.......((.((..((((....))))..))....))........))).))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..(((((((..(.((((((((.(((..(((((((...(((())))...)))))))..))).)))))))))..)))))))...).))...)..)..(((((((((....)))))))))}........ High-resolution C. elegans 80S ribosome structure - class 1; 18S rRNA 9bh5 A5 3022 2.63 RF02543 39209556 0003735 0005840 6239 cucaaccugaacucagucgugauuacccgcugaacuuaagcauaucauuuagcggaggaaaagaaacuaaaaaggauucccuuaguaacggcgagugaaacgggaagagcccagcgccgaaucgaucagucuuuggcugcuucgaaauguggcguauagguguaaguuuccagcagugucguauguccgaaguccuuacgauugaggccauaaaccagagagggugcgagccccguucuggauagcggcacuguugguucgcuugcuccuuggagucggguugcuugaaagugcagccuaaagugggugauaaacuucaucuaaggcuaaauaucgacucgauugcgauagcgaacaaguaccgugagggaaaguugcaaaggacuuugaagagagaguucaagagaacgugaaaucgcuggaguggaaccggagacaguugauuacgccgacggcguuggcugcucguucuagcccgacaguguugcgucuugcuggcgguaguggguucguggcggcuagcguacgucggugugaaagucgacgacguuuccgacccgucuugaaacacggauugcggagugcuugucuacugcgagucaaaggguguuaaaaccuugcggcgaaaugaaaguaaaggucagucucgaauuggccgacgugggaucugugugugcagcgcaccacggcccugugcgugucacuugugacugugcagagguugagcaguuggcaaacgacccgaaagauggugaacuaugccugagcaggaugaagccagaggaaacucugguggaaguccguaucgguucugacgugcaaaucgaucgauagacuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccuuccgaaguuucccucaggauagcuggaucucaggcaguuauauucgguaaagcuaaugauuagaggaaccuauucucaaacuuucaauggauaugaaguugcaguuucuuuagugaacugucaacgugaaugcgagguccaagugggccauuuuugguaagcagaacuggcgcugugggaugaaccaaacguggaguuaaggugccuaacuucucgcucaugagaccccauaaaagguguugguugauauugacagcaaucaacuagcccugaaaauggauggcgcuuaagcgagagaccuauacuccgccguugcgacaaggucguaacgaguaggaaggucguggcgguugcguugaaggcugagcguaggcucggcuggagcuuccgucagugcagaucguaaugguaguagcaaauauucaaguucgauccuugaagacugaaguggagaaggguuccacgugaacaguaguuggaugugggucagucgauccuaagguacuggcgaacgccuuguaucaucgguggcgguccccgcuugucgaaagggaauaggguuaauauucccuaacugagaugcaaagauugugugcacaagcgcgguaacgcauucgaacuugguuagucgcucaaagaccgagcuagaguuuucuucucuaguuaaggaacggacucccuggaauugguucagccagagauggggacguuguuuccgaaaagcaccgcguggugucucgugcucuuugaacggcccuuaaaacaccaagggaggcuauuaauuugcacucaaucguaccgauauccgcauuaggucuccaaggugaacagccucuagucgauagaauaauguagguaagggaagucggcaaacuagauccguaacuucgggaaaaggauuggcuccagugguuaccguacuggaaccgguacggacucagggaauccgacugucuaauuaaaacagaggugacagaugguccuugcggacguugacugucacugauuucugcccagugcucugaauguuaaaucguaguaauucgaguaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucauuuaauuguugacgcgcaugaauggauuaacgagauuccuacugucccuaacuacuuucuagcgaaaccacagccaagggaacgggcuuggcaaaaauagcggggaaagaagacccuguugagcuugacucuaguuugacauugugaagagucagacucuuuacuuauucgguuaaaagagaauuucgaagcauuaagcggagccauuauggcaccgugacucuccucgaagacagugucaagcggggaguuugacuggggcgguacaucuaucaaaucguaacguagguguccuaaggcgagcucagagaggacggaaaccucucguagagcaaaagggcaaaagcuugcuugaucuugacuuucaguacgaguacagaccgcgaaagcguggccuaucgauccuuuuaauccugauuguuucagguaagaggugucagaaaaguuaccacagggauaacuggcuuguggcagccaagcguccauagcgacguugcuuuuugauccuucgaugucggcucuuccuaucauugcgaagcagaauucgccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacuguugacuuguuauugcgaaaguaauccugcuuaguacgagaggaacagcggguucaaacauuugguucauagacuugaucgacagaucaauggucugaagcuaccauuugagagauuauaacugaacgccucuaaguuagaaucucgccuugucaaggcgaaaauuuugcuucccggugucgggaggcaucucuaucucguggcaacacgagagcuuaugcccuauguauggccuuggcgucguagugauucugcgacgcuugccaacgccagaucacucugguucaaugucggggcgcuaaaucacuugcauacgacuugguggucaagguguuguauucaguagagcaguccuuuuauacugcgaucuguugagacuauccuuugauugauuuuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..<<<..<<<<<<..<<<<.<<<<<...>>>>>..>>>>....>>>>>>..<<<.<<<<<<..<<<<<<<<<<<<<.<<<<<.<...<<<<......>>>>..............<<<.......>>>..>..>>>>>>>>>>>>>>>>>>...>>>>>>.>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((..>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<<<.<<<<<...<<<<<<<<<<<<<<<<<<<<<<..<<.<<<<<.<<<<...<...>..>>>>.>>>..>>.>>..>>.>>>>>>>>>>>>.>>>>>>>>......>>>>>...>>>>>>>..<<<<........>>>><<<<<<...<<.<<<<<.<<<<<..<<<...<<<<......>>>>...>>>...<<....>>...<<<<<<<.....>>>>>>>..<<<<<...<<<<<..>>>>>....>>>>><<<<<<<<<<.<<<<<..>>>>>>>>>>>>.>>>...>>>>>.>>>>>.>>.<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>..<<<<..<<.<<........>>>>.>>>>...>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<..<<<.<<<<<<<<<...<<<....<<<....<<<..>>>....>>>..>.>>...>>>>>>>...<<<<<<<<<.<......>>>>>>.>>>>...>>>>>>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<......<..........<<<.<<<<<<<<<<..........>>>>>>>>>>>>>..........))).>....>>>>>>.>>>>..>>>>>>><<<<<<<<<...>>>>>>>>>....>>>>>>...<<<<<<..<<......<<<<<<<<....>>>>>>>>...>>..>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<....<<.....>>..>>>>>....((<<<<<<...<<<...<<<....>>>.........<<<.<<...>>.>>>...>>>....>>...<<<<<........>>>>>))<<<<.<<<<<<..<<<<<..>>>>><<<<<....>>>...<.((<<<<<<..<<<<.<<<<<<<.<<<<<<<<<<...[[..>>>>>><...<<<<<<...<<<<<<....<<<<...>>>>....>>>>>>...>>>>.>>....><<<<<<..>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>...>>>......>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<<....<<<<.<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<.>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<....>>>>......>>>>>>>...<<..<<<..<<<<<<.....<<....<<<.<....>.>>>....>>..>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<.<.....>.>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>.>>>>.>>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<<<<.>>>>>>>>>>...<<<<<.....<<<<............))..<<<<.<<<<<.>>>>>.>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......<<<<<<..<<<<...))))>>>>>>>>>>..........>>>>..>>>>>>.......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<.<<<<..<<<..<.<<<<<<...............>>>>>>.><<<<....<<<<....<<<<<<<<<<]]..>>>>>..>>>>>...>>>>...>>>>.<<<<...<<<<<...........>>>>>...>>>>..>>>......>>>>.>>>...<<.<<<<<<<<<.<<..<<<.......<<<<<<<....>>>>>>>......>>>....<..<<<<...<<<<<<<<<<.....>>>>>>>>>>.>>>>...>..............>>.>>>>>>>>>.>>.<<<...<.............>.<<<<<<<<<.<<<.....<<<....<<<<<........>>>>>...>>>....>>>...>>>.>>>>>>...>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..(((((.(((((...)))))..))))....)))).....((.((((((..(((((((((((((.(((((...({((((......)))))......[(...).(((....}].))).....))))))))))))))))))...)))))).))...)....(((((((........))))))).....(((((..[[[[..)))))..)))..................................((....))............(..((((....))))............).....................(((((((.((((((.)((((((((((((((((((((((..((.(((((.((((...(().)..)))).)))..)).))..)).)))))))))))).))))))))......)))))...))))))).<((((........))))((((((....(.(((((.(((((..(((...(((........)))...)))...((....))...(((((((.....)))))))..(((((...(((((..)))))....)))))(((((((((..(((((..))))).)))))).)))...))))).))))).)..((.(...((((((.....((((((((((.(((....(((((((....)))))))....<)))...(((..((.((........)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((..(((.((((((((....(((....(((..(.(((..))).)..)))..)).)....))))))...(((((((((.(......)))))).))))...))))))))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{....)))))))))))))..........]]].)....))))))))))...)))))))(((((((((...)))))))))....)))))).(.((((((..((......((((((((....))))))))...))..))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...((((((...((.....)).))))))....[[(((.((...(((...(((....))).........(((.(((.))).)))...)))....))...(((((........)))))]]((((.((((((..(((((())))))(((((....)))...(.[[((((((..((((.(((((((((((((((((....{{...)))))(...(((((....(((((.....(((.....))).....)))))....))).))....)((((((..)))))))))).).))))))).)))).........))))))...)))......)))))))))).)))..)).....((......)).)))).((((.....))))..))))..((((.....((((.((.((..(....(.......(((((....(.[..).....)))))((.(((((((((.)))..)))))).))(...)(....).(((((((((.>.((.........))...(((((((....((((....))))......))))))).].(((.(((..((((((.(...((....(((.(....).)))....)).)))))..)))))(((((.........)))))........((.(......).((((.(.....).))))..)..)....)))....)).))))))).)..))).)).))))..))))))....)).[..(((((.....>].)))))....((.((..(((.((......((((.((((((..(((((.(((((((((.((((((((((.))))))))))...(((((.....((((............]]..((((.(((((.))))).))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....(((((.(.((((...]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))....))..))).)).))......((.((((..(((..(.(((((......(....).....))))).)((((....(((.....((((((((((}}..)))))..)))))....)))...)))).((((...((((.....}.......))))...))))..)))......)))).))....((.(((((((((.((..(((.......(((((((....)))))))......)))....(..((((...(((((((.((.....)).))))))).))))...)..............)).))))))))).)).(((...(..(.......)..)..((((((((.(((.....(((.(..(((((........)))))..))))....)))...))).)))))....))).. High-resolution C. elegans 80S ribosome structure - class 1; 28S rRNA 9bh5 DA 76 2.63 RF00005 39209556 0030533 6239 gccucgauagcucaguugggagagcguacgacugaagaucguaaggucaccaguucgauccugguucggggcacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((.(((..((((.....[..)))).(((((.......))))).....(((((..]....)))))))).))).... High-resolution C. elegans 80S ribosome structure - class 1; tRNA 9bh5 DB 76 2.63 RF00005 39209556 0030533 6239 gccucgauagcucaguugggagagcguacgacugaagaucguaaggucaccaguucgauccugguucggggcacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).(((((.......))))).....(((((..]....)))))))))))).... High-resolution C. elegans 80S ribosome structure - class 1; tRNA 9bh5 DC 10 2.63 39209556 6239 uuuuuuuuuu .......... .......... High-resolution C. elegans 80S ribosome structure - class 1; mRNA 9bih G 28 3.24 39755678 2697049 uuuagauuucaucuaaacgaacaaacua ............................ ............................ SARS-CoV-2 endoribonuclease Nsp15 bound to dsRNA with 1 nucleotide bulge; RNA (35-mer) 9bih H 27 3.24 39755678 2697049 uaguuuguucguuugaugaaaucuaaa ........................... ........................... SARS-CoV-2 endoribonuclease Nsp15 bound to dsRNA with 1 nucleotide bulge; RNA (34-mer) 9bs0 A 2678 3.3 RF02540,RF02541,RF02543,RF00002 39658043 0003735 0005840 224308 uuaaguuagaaagggcgcacgguggaugccuuggcacuaggagccgaugaaggacgggacgaacaccgauaugcuucggggagcuguaagcaagcuuugauccggagauuuccgaauggggaaacccaccacucguaauggagugguauccauaucugaauucauaggauaugagaaggcagacccggggaacugaaacaucuaaguacccggaggaagagaaagcaaaugcgauucccugaguagcggcgagcgaaacgggaucagcccaaaccaagaggcuugccucuugggguuguaggacacucuguacggaguuacaaaggaacgagguagaugaagaggucuggaaaggcccgccauaggagguaacagcccuguagucaaaacuucguucucuccugaguggauccugaguacggcggaacacgugaaauuccgucggaauccgggaggaccaucucccaaggcuaaauacucccuagugaccgauagugaaccaguaccgugagggaaaggugaaaagcaccccggaaggggagugaaagagauccugaaaccgugugccuacaaguagucagagcccguuaacgggugauggcgugccuuuuguagaaugaaccggcgaguuacgaucucgugcaagguuaagcagaagaugcggagccgcagcgaaagcgagucugaauagggcgcaugaguacguggucguagacccgaaaccaggugaucuacccauguccagggugaaguucagguaacacugaauggaggcccgaacccacgcacguugaaaagugcggggaugagguguggguaggggugaaaugccaaucgaaccuggagauagcugguucucuccgaaauagcuuuagggcuagccucaagguaagagucuuggagguagagcacugauuggacgaauucagucaaacuccgaaugccaaugacuuauccuugggagucagacugcgagugauaagauccguagucgaaagggaaacagcccagaccgccagcuaaggucccaaaguauacguuaaguggaaaaggauguggaguugcuuagacaacgucgagugacucugcgccgaaaauguaccggggcuaaacguaucaccgaagcugcggacuguucuucgaacagugguaggagagcguucuaagggcugugaagccagaccggaaggacugguggagcgcuuagaagugagaaugccgguaugaguagcgaaagaggggugagaauccccuccaccgaaugccuaagguuuccugaggaaggcucguccgcucaggguuagucgggaccuaagccgaggccgaaaggcguaggcgauggacaacagguugauauuccuguaccaccuccucaccauuugagcaauggggggacgcaggaggauaggguaagcgcgguauuggauauccgcguccaagcaguuaggcugggaaauaggcaaauccguuucccauaagccugagcugugauggcgagcgaaauauaguagcgaaguuccugauuccacacugccaagaaaagccucuagcgaggugagaggugcccguaccgcaaaccgacacagguaggcgaggagagaauccuaaggugaucgagagaacucucguuaaggaacucggcaaaaugaccccguaacuucgggagaaggggugcucuguuagggugcaagcccgagagagccgcagugaauaggcccaggcgacuguuuagcaaaaacacaggucucugcgaagccguaaggcgaaguauaggggcugacgccugccggugcuggaagguuaagaggagccgaauugaagccccaguaacaacgaucugggcacugucucaacgagagacucggugaaauuauaguaccugugaagaugcagguuacccgcgacaggacggaaagaccccguggagcuuuacugcagccugauauugaauguugguacagcuuguacaggauagguaggagccuuggaaaccggagcgccagcuucgguggaggcaucggugggauacuacccuggcuguauugaccuucuaacccgccgcccuuaucgggcggggagacagugucaggugggcaguuccuccuaaaagguaacggaggcgcccaaagguucccucagaauggucauucgcagaguguaaaggcacaagggagcuugacugcgagaccuacaagucgagcagggacgaaagucgggcuuagugauccggugguuccgcauggaagggccaucgcucaacggauaaaagcuaccccaucucccccaacggggagguuuggcacggcucaucgcauccuggggcuguagucggucccaaggguugggcuguucgcccauuaaagcggucagaacgucgugagacaguucggucccuauccgucgcgggcgcaggaaauuugagaggagcuguccuuaguacgagaggaccgggauggacgcaccgcugguguaccaguuguucugccaagggcaucgcuggguagcuaugugcggacgggauaagugcugaaagcaucuaagcaugaagccccccucaagaugagauuucccauuccgcaaggaaguaagaucccugaaagaugaucagguugauaggucugagguggaaguguggcgacacauggagcugacagauacuaaucgaucgaggacuuaac <<<<<<......<<<<<<<<<<<....<<<..<<<<<<<<<<<<<......<<<<<<.....((.>>>.....<<<<<<<..<<<)).....>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<<<<<<<<.........>>>>>>>.>>.>>....<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<......<<.....>>.....>>>>...<<<....<<<<.<<<....>>>.>>>>......<<<<<<<<<.....<<<<.......<<<<<<<<<<.<<<.....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>.>>>>>..>>>>.....<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>.............>....>>>>>>>>>>>.......<<<<..<<<<......>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<.<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>......>>>>>.>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<......>>>><<<<<<<<<...<<<<<<<<<.....<.<...<<<<<<........>>>>>>..>..>.....>>>>.>>>>>..>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<.<.<................>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<...>>>>>>>....>>>>>><.<<<<<<<.<<......<<<<<.<<....>>.>>>>>...>>.>>>>>>>..>.....>>>>>><......<<....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<.<<<<<<......<<...<<<<....<<<<..<<<..<<<.<.<<<.<...[.[....>.>>>.<<..<......<<<<.<<<<<<<.<<.....>>>>>>>>>....>>>>......>...>><..<<...........>>...>>.>>>...>>>...>>>>.........>>>>..>>..>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<....<<<<....>>>>...>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.............<<<<.........<...........>.......>>>>.....>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.<<...........<<<<<<..<<<<<.<<<<<<<<<.<<<.<<<<<<<<<<<<...........<<.....<<..........<<<<<....>>>>>.......>>...............>>..>>>>>>>>>>>>.>>>....<<.<<<<<<.....>>>>>>>>.....>>>>>>>>>..>>>>>.<<.................>>...........<<<<...<<.......>>....................>>>>......<<<<..<<<......>>>..>>>>..........................<.....<<..))))..>>....>...............>>>>..>>...<<.<<<.....>>>.>>..............<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>...<<<<<<<....>>>.>>>>....>>..>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.].]>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>. ((((((......((((((((((.....(((..(((((((((((((......((((((..[..[[[)))...].((((((...(((]]..]..)))......))))))...)))....(((....)))(((((((......)))))))..(((((((...........)))))).)..))....((((((.....(......)......))))).).........((....))...((((......((.....)).....))))...((((...((((.(((....))).))))....[.(((((((((.....((((.......(((((((.((.(((...(.((((......)))))[[(...).(((.....]])))...)))...)).))))))))))).)))))..)))))....((((((((.........))))))))....].(((((.....[)))))..)))......)).))))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((..((((..<...))))..)))).[.(.(........).).((((((....(((((((.(((((..(((...(((.....)))...)))...((....))..((((.....))))......))))).)))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......A))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....((((......))))(((((((((...(((((.........(.(...(((.((........)).)))..)..)..........)))))..))))))).))..(((((((.((......)).)))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(.((....((.....{........))....)).).))...........]]].)...))))))))))...)))))))(((((((...)))))))....))))))(.(((((...((......(((((.((....))>)))))...))...)))))..).....))))))(......((....((((((.......))))))((((....(((...((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((.((((((......((...((((....((((..(((..(((.(.(((.(.....{....).))).((....(....((((.((((((..((.....)).))))))....)))).....)....))(..((...........))...)).)))...)))...))))(..).....))))..))..))))))))))))))).))).....((......))..))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))(((((....((((....))))...)))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}............((.(...((...((.........))...))..)))......)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((...........((((((..(((((..((.(((((.(.(.((..((((((((.(.........((.....((..........(..((....))..).......))...............))).))))))))..)).).)....((.((((((.....)))))))).....))))).))...))))).((.................))..............(....(.(....)).....................).........((.(...((......))...).))................................((..].....))....................))))..))...(...(........)..).............(((((..((((((((........)))))..))).(((((.....))))).....)))))..(((((((....))).))))..a.))..)))))))))))[...(((((((...((((..((((((......(....).....)))))).(((((...((((...(((((((((((.}..))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((....))))....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))...))))))). YphC-treated 45SYphC particle. Class 5; 23S rRNA 9bs0 B 111 3.3 RF00001 39658043 0003735 0005840 224308 ugguggcgauagcgaagaggucacacccguucccauaccgaacacggaaguuaagcucuucagcgccgaugguagucggggguucccccugugagaguaggacgccgccaa <<<<<<<....<<<<<<<<.......<<.................>>........>>>>>>.>>.<<.......<<.<<<<<..>>>>>.>>.......>>..>>>>>>>. (((((((....((((((((.....(.((.....(.....).....))...)....)))))).)).((........(.(((((..))))).)........))..))))))). YphC-treated 45SYphC particle. Class 5; 5S rRNA 9bss A 2572 3.1 RF02540,RF02541,RF02543,RF00002 39658043 0003735 0005840 224308 uuaaguuagaaagggcgcacgguggaugccuuggcacuaggagccgaugaaggacgggacgaacaccgauaugcuucggggagcuguaagcaagcuuugauccggagauuuccgaauggggaaacccaccacucguaauggagugguauccauaucugaauucauaggauaugagaaggcagacccggggaacugaaacaucuaaguacccggaggaagagaaagcaaaugcgauucccugaguagcggcgagcgaaacgggaucagcccaaaccaagaggcuugccucuugggguuguaggacacucuguacggaguuacaaaggaacgagguagaugaagaggucuggaaaggcccgccauaggagguaacagcccuguagucaaaacuucguucucuccugaguggauccugaguacggcggaacacgugaaauuccgucggaauccgggaggaccaucucccaaggcuaaauacucccuagugaccgauagugaaccaguaccgugagggaaaggugaaaagcaccccggaaggggagugaaagagauccugaaaccgugugccuacaaguagucagagcccguuaacgggugauggcgugccuuuuguagaaugaaccggcgaguuacgaucucgugcaagguuaagcagaagaugcggagccgcagcgaaagcgagucugaauagggcgcaugaguacguggucguagacccgaaaccaggugaucuacccauguccagggugaaguucagguaacacugaauggaggcccgaacccacgcacguugaaaagugcggggaugagguguggguaggggugaaaugccaaucgaaccuggagauagcugguucucuccgaaauagcuuuaggcuagccucaagguaagagucuuggagguagagcacuuccgaaugccaaugacuuauccuugggagucagacugcgagugauaauccguagucgaaagggaaacagcccagaccgccagcuaaggucccaaaguauacguuaaguggaaaaggauguggaguugcuuagacaaccagcuggucgagugacucugcgccgaaaauguaccggggcuaaacguaucaccgaagcugcggacuguucuucgaacagugguaggagagcguucuaagggcugugaagccagaccggaaggacugguggagcgcuuagaagugagaaugccgguaugaguagcgaaagaggggugagaauccccuccaccgaaugccuaagguuuccugaggaaggcucguccgcucaggguuagucgggaccuaagccgaggccgaaaggcguaggcgauggacaacagguugauauuccuguaccaccuccucaccauuugagcaauggggggacgcaggaggauaggguaagcgcgguauuggauauccgcguccaagcaguuaggcugggaaauaggcaaauccguuucccauaagccugagcugugauggcgagcgaauagcgaaguuccugauuccacacugccaagaaaagccucuagcgaggugagaggugcccguaccgcaaaccgacacagguaggcgaggagagaauccuaaggugaucgagagaacucucguuaaggaacucggcaaaaugaccccguaacuucgggagaaggggugcucuguuaggagagagccgcagugaauaggcccaggcgacuguuuagcaaaaacacaggucucugcgaagccguaaggcgaaguauaggggcugacgccugcgcaacgaucugggcacugucucaacgagagacucggugaaauuauaguaccugugaagaugcagguuacccgcgacaggacggaaagaccccguggagcuuuacugcagccugauauugaauguugguacagcuuguacaggauagguaggagccuggcaucggugggauacuacccuggcuguauugaccuucuaacccgccgcccuuaucgggcggggagacagugucaggugggcaguuuuccuaaaagguaaggaggcgcccaaagguucccucagcagaguguaaaggcacaagggagcuugacugcgagaccagucgagcagggacgaaagucgggcuuagugauccggugguuccgcauggaagggccaucgcucaacggauaaaagcuaccccgggaucucccccaacggggagguuuggcacccggcucaucgcauccuggggcuuagucggucccaaggguugggcuguucgcccauuaaagcgguacgcgagcuggguucagaacgucgugagacaguucggucccuauccgucgcgggcgcaggaaauuugagaggagcuguccuuaguacgagaggaccgggauggacgcaccgcugguguaccaguuguucugccaagggcaucgcuggguagcuaugugcggacgggauaagugcugaaagcaucuaagcaugaagccccccucaagaugagauuucccauuccgcaaggaaguaagaucccugaaagaugaucagguugauaggucugagguggaaguguggcgacacauggagcugacagauacuaaucgaucgaggacuuaac <<<<<<......<<<<<<<<<<<....<<<..<<<<<<<<<<<<<......<<<<<<..[..((.>>>.....<<<<<<<..<<<))..]..>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<<<<<<<<.........>>>>>>>.>>.>>....<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<......<<.....>>.....>>>>...<<<....<<<<<<........>>>>>>.......<<<<<<.......<<<<.......<<<<<<<<<<.<<<.....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>...>>>..>>>......<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>.............>....>>>>>>>>>>>.......<<<<..<<<<......>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<.<<<<<..<<<...<<<.....>>>...>>>...<<....>>....<<.....>>........>>>>>.>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<...>>>>><<<<<<<<<...<<<<<<<<<.......<...>........>>>>.>>>>>..>>>>>>>.>>..<<<<<<<.<<....>>.>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<......>>....>>>>>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<...>>>>>>>....>>>>>><.<<<<<<<.<.......<<<<<.<<....>>.>>>>>....>.>>>>>>>..>.....>>>>>><......<<....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<.<.<<<...<<<....>>>...>>>..>>>...<<<<<........>>>>>))<<<<<.<<<<<<......<<...<<<<....<<<<..<<<..<<<.<.<<<.<.....[....>.>>>.<...<..<<<.<<<<..<<<<<<.<<.....>>>>>>>>.....>>>>..>>>.>....><..<<.....>>...>>.>>>...>>>...>>>>.........>>>>..>>..>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<........>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>..<<<..>>>...>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.<<......<<<<.<<<<....<<<<<.<<<<<<<<<.<<<.<<<<<<<<<<<<...........<<............................>>.>>>>>>>>>>>>.>>>....<<.<<<<<<.....>>>>>>>>.....>>>>>>>>>..>>>>>...<<..........>>.............<<<..........<<....((>>......>>>.....<<<<..<<<..>>>..>>>>.<<<....>>>...))........<<<.....<...))))..>.....>>>...............>>..>>>>>>...<..<<<....>>>.>...........<<<.<<<<<<..<<<<<<<<<.....>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.......<<<<<<<....>>>.>>>>....>>..>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<.....<....>....>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.]..>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<....>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>. (((((.......((((((((((.....(((..(((((((((((.(.(....((((((..[..[[[)))...].((((((...(((]]..]..)))......))))))...)))...)(((....)))(((((((......))))))).(((((((((.........))))))).)).).....((((((.....(......)......))))).).........((....))...((((......((.....)).....))))...(((....((((((.(....).)))))).......(((((........((((.......((((((((((.(((...(.((((......)))))[[(...).(((.....]])))...)))...))))))))))))))....))..)))......((.(((((.........))))).))......(((((..[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((..((((..[...))))..))))...(.(........).).((((((....(((((((.(((((..(((...(((.....)))...)))...((....))..(.((.....)).)......))))).)))))))..((.(...((((((.....((((((((((.((((...((((.(......).))))...){)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((.......)))(((((((((...(((((.((......((.....).)......).).)))))..))))))).))..(((((((..(....)..)))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(..((((.((.........(.....)....)).))))..).))...........]]].)...))))))))))...)))))))(((((((...)))))))....))))))(((((((...((......(((((.((....))])))))...))...))))).)).....))))))(......((....((((((.......))))))((((....(((...((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]](((((.((((((......((...((((....((((..(((..(((.(.(((.......<......)))..(.........((.(..((((((.((.....)))))))).....).))..........).(..((.....))...)).)))...)))...))))(..).....))))..))..))))))))))))))).))).....((......))..))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.[..).....)))))(((((........)))))(...).......(((((((((.}.((.........))...((((((......(((....)))........)))))).](((..)))...)).))))))).)..))).)))))))).)))))).....)).[..(((((......].)))))..((((((((.(((.((......((((.(((.....(((((..(..(((((...(.((.(.(((((((.(..........(............................)).))))))).).)).)......((.((((((.....)))))))).....))))).)....)))))....(..........).....([.(....(.((..........(.][...[.)......)).).......(..(((..)))..).....((....))..).]...]....(.(.(........]]]].......).)).....)..........)..))))))..(...(........)..).........((((.((((((..((((.(((.......))).)..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.>..))))))..)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.((((....))))....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))...).))))). 45SRbgA particle in complex with RbgA and YphC. Class B; 23S rRNA 9bss B 112 3.1 RF00001 39658043 0003735 0005840 224308 ugguggcgauagcgaagaggucacacccguucccauaccgaacacggaaguuaagcucuucagcgccgaugguagucggggguuucccccugugagaguaggacgccgccaa <<<<<<<....<<<<<<<......<<.......................>>.....>>>>>.>>..........<<.<<<<<...>>>>>.>>...........>>>>>>>. (((.(((....(((((((.(....(.(...................)...)....)))))).))..(.......(..(((((...)))))..).......)...))).))). 45SRbgA particle in complex with RbgA and YphC. Class B; 5S rRNA 9bz1 A 84 2.8 RF01750 0006730,1900371 1520 uagucauaugacugacggaaguggaguuaccacaugaaguaugacuaggcauauuaucuuauaugccaagccgaccgucugggc <<<<<<<<<....(((((..<<<<.....>>>>.....>>>>>>>>><<<<<<<......>>>>>>>..<<<..)))))..>>> (((((((((..(.[[[[[..((((.....))))..)..)))))))))(((((((......)))))))..(((..]]]]]..))) Cocrystal structure of Clostridium beijerinckii ZTP riboswitch with AICA; RNA (84-MER) 9bz1 B 84 2.8 RF01750 0006730,1900371 1520 uagucauaugacugacggaaguggaguuaccacaugaaguaugacuaggcauauuaucuuauaugccaagccgaccgucugggc <<<<<<<<<....(((((..<<<<.....>>>>.....>>>>>>>>><<<<<<<......>>>>>>>..<<<..)))))..>>> (((((((((..(.[[[[[..((((.....))))..)..)))))))))(((((((......)))))))..(((..]]]]]..))) Cocrystal structure of Clostridium beijerinckii ZTP riboswitch with AICA; RNA (84-MER) 9c3h L1 148 2.0 RF00002 URS0000005270_9606 39571015 0003735 0005840 9606 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauuncaggacaugaucaucgacacuucgaacgcacuugcggccccgggcccggggcuacgccugucugagcgucgcu .........................................<<<<<<<<<....>>>>.....<.<<<......>>..........>>>..>...>>>....<<....>><<<<<<<<<>>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]]..........)))..)...)))....((....))((((((((())))))))).................... Structure of the CNOT3-bound human 80S ribosome with tRNA-ARG in the P-site.; 5.8S rRNA 9c3h L5 3531 2.0 RF02543,RF02540,RF02541 39571015 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagngngaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcgggcggaucuggggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcunggaaggcccggcggggaagguggcucgggggcccccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcgcucuccccccucccggcgcgccggggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccgggggaggccacgcgcgcgucccccgaagagggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccnucuugnaacncggaccaaggagunuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgagggngcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuagnacccnanagauggugancuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauagnggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcacccgacgccacgcaguuuuauccgguaaagcgaaugauuagaggucuuggngucncaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcngaacuggcgnugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaccgaaucaacuagcccugaaaauggaugncgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaunuuggugguagunnnaaauauucaaacgagaacuuugaaggccgaaguggngaaggguuccaugngaacagnanuugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcuugcccucggccgaucgaaagggagucggguucagauccccgaauccggagcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccnuauccgcagcaggucuncaaggugaacngccucuggnauguuggaacaanguagguaagggaagucggcaagcnggauccguaacuucnggauaaggauuggcucuaagggcugggucggucgcggccggcgccuagcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugccnagugcucugaaugucanagugaagaaauucaaugaagcgcggnuaaacggcgggaguancuaugacucucuuaagguagcnaanugccucnucaucuaauuagugangcgcaugaanggaugancgagnuucccacugunccuaccuacuauccagcgaaaccacngncaagggaacgggcuuggnggaaucagcggngaaagaagacccuguugagcuugacncuagucuggcacggugaanauuuuucacugacccggugaggcgggggggcgagccggcucucgcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacugnggcgguacaccugucaaacgguancgcaggnnuccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucagnacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggangugucagaaaaguuaccacagngauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuungaugucggnucuuccuaucauugugaagcagaauucaccaagcguungaunnuucacccacuaauagggaacgugngcugggnuuagancgucgugagacagguuaguuuuacccuacugaugnuguguuguugccaugguanuccugcucaguacgagaggaaccgcagnuncanacauuugguguaunugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccggucccccgccgggguccgguncngagugcccuucguccugggaaacggggcgcggccggaaaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu ..........................<<<<<.....<......>......>>>>>...........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>>..<<<<<<<<<<...<<<<<<<<...<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>...>>>>>>>>..>>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<......>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<<<..<<<<<<<.<<<<<.<<<<<<.<<<..>>>>>>>>>.>>>>>>>>>...>>>>>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<<<<<<<<<<<<<<<<<...<<..<<<....<<<<......<<<<.<<.....>>>>>>.......>>>>...>>>........>>>>>>..>>>>>>>>>>>....................<<<<<<.<<<<<<<.....<..>...>>>>>>>.<<<<<<.<<<<.<<<<<<<<<<..<<<<<.<<<<..<...........>...>>>>.>>>>>...>>>>>>>.>>>...>>>>..>>>>.>>..<<<<<<<<<<.....>>>>>>>>.>>....>>>>>>.....>>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<......>>>>>>>..<<<<<...<<<..<<<..{[[[.((((>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<................<<<.<<<<<<<<<...<<<....<<<..<.<<<<.<..<<..>>.>>>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.........>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<..............>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<..........))))]]].}...............>>>>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<..>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<.<<<<<..<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<.<<<<<<<<<<<...<..........>........>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<...>>>>>>...<<<<<.....<<<<..<<.<<<<<>>>>>>>..............<<<<<<<<<<.......>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>><<<<....>>>>>>)))].....<<<<<<<..<<<..)))))).>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>........<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>.....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<]]].>>>>>..>>.>>...>>>>...>>>><<<<....<<<<<...........>>>>>....>>>>.>>>...>.>>>>>>.....<<<<<<<.<<..<<<<....<<<........<<<<<.<<<<....>>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>..............>>>>..>>>>>>>>><<<<<....................<<.<<<<<<<.<<.....<<<<.<..<<<<<......>>>>>..>>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..(((((((((.(.....).)))).))))....))))....((((((((((...((((((((...((((((((..({((((......)))))....[[(...).(((....}]])))...).)))))))...))))))))..))))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....(((((((((((..(((((((.(((((.((((((.(((..))))))))).)))))))))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((..(.((((.......((..((....).).))........))))..))))........))))))..)))))))))))......{.............((((((.((((((..............)))))).((((((.((((.((((((((((...(((..(((....................)))..)))....))))))).)))...))))..)))).))..((((((((((.....)))))))).))..[.)))))).....))).)))))...)))))...)))))))).<((((........))))((((((..(.(((((((((((((..(((..((((..........)))..)..)))...((....))...(((((.(......).)))))..(((((...(((..(((....[..[[[[)))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......B)))).)))..).))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((.(((((((................(((.((((((((.....((.....((....((((.(..((())).)))))....))...))......))))))...(((((((((.(......))))))))))....))))))))))))..))..((((..(.((.....)).)..))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.....A.(..)...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((........}.]]]].]...].(...)........)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((..(((((((...((.....)).))))))....[[(((.((...(.....(((....)))..........((..(((..))).)).......)....))...(((((........)))))]]((((.(((((...((.((((....)))).))..((((....)))...(...((((((...((((((((((((((((((((((...{{{...)))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).))).))).....((......)).)))).((((.....))))..)))....(((......((((((..((..(....(.......(((((....(.[..).....)))))((.(((((((((((...(.(.......))........)))))..)))))).))(...).......(((((((((.>.(...........)...(((((((....((((.....))))......))))))).].(.(.(((..((((((.(...(......((.(....).))......).)))))..)))))(.(.(.........).).)........((..........(((((.......)))))..)..)....).)....)).))))))).)..)))..))))))...)))))....)).[..((.((.....>].)).))....(((((..(((.((......((((.(((((...(((((.(((((((((.(((((.(.).)))))...(((((.....((((..((.((((()))))))..............((((((((((.......))))))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(..((....((....{..))....)).)(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}.....)))..)))))).......(....(.((((.(...((.......))...).))))...)....)........((((.((((((..(.(.(.(((......))).)...).).(((.(.....).))).....)))))..)...))).)......((((((....))).)))...b.))..))).))))).....(.((.(.(..(((..(.(((((......(....).....))))).)(((.....((((....((.(((((((}}}.)))))..)).))...))))....))).((((...((((.....a.......))))...))))..)))...).).)).).....(((((((.((..((((.(..(((........(((((.((((....)))).))))).......)))...(((..((((....((((.(((((((......)))))))))))...))))..)))...........)..))))..)))))))))(((((....(.......).......((.(((((((.((.....(.((.(..(((((......)))))..))).)....))....)))).))).))..))))).. Structure of the CNOT3-bound human 80S ribosome with tRNA-ARG in the P-site.; 28S rRNA 9c3h L9 120 2.0 RF00001 39571015 0003735 0005840 9606 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. Structure of the CNOT3-bound human 80S ribosome with tRNA-ARG in the P-site.; 5S rRNA 9c3h S4 76 2.0 39571015 9606 ggccgcgunnccuaangnanaaggcnucugauuccgnaucagaaganugagggnucgngucccuucguggucgcca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((....[...))))..((((.......))))......(((((..]....)))))))))))).... Structure of the CNOT3-bound human 80S ribosome with tRNA-ARG in the P-site.; tRNA-ARG,CCG-1 9c3h S2 1660 2.0 RF01960,RF02542,RF01959,RF00177 39571015 0003735 0005840 9606 uaccugguugauccugccaguagcaunugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucnuuaaaucaguuauggunccuunggucgcucguacuuggauaacugugguanuucuagngcuaananaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgccccccguggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgaunccggaganggagccugagaaacggcuaccacauncaaggnaggcagcaggcgcgcnaauuacccacucccgacccggggangungugangaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaanuccuuuaacgaggnuccauuggagngcaagucuggugccagcagccgcggnaauuccagcuccaauancguauauuaaaguugcugcaguunaaaagcucguaguungaucuugggnuuacuuugaaaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaaungaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagancgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacncaacacgggaaaccucacccggcccggacacggacagganugacagauugauagcucuuucucgauuccguggguggngnugcauggcnguucuuaguugguggagcgauuugucugguuaauuccgauaacgancgagacunuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuncuuagagggacaaguggcguucagccacccgagauugagcaauaacangucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgagnaauucccaguaagugcgggucauaagcuugcguugauunagucccugcccuuuguacacaccgnccgucgnuacuaccgauuggaugguuuagugaggcccucggaucggcgcugagaagacggucgaacungacuaucuagaggaaguaaaagucguancaagguuucnguaggugnnccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<....<<....<<<<..........<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<<......>>>>>...>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<<......>>>>>>>>..>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....<<<<...<<..<<....>>..>>.....>>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<........<<<<<<.<.......<<...<.......>.<<<<.......>>>>...>>......>.>>>..>>>........<.<<.<<<<<<<...............>>>>>>>.>>.>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<<....>>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<.......>>>>.>>>>.....>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>............<<<<<..........>>>>>...........>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))((...(((((......(..((.....(((.(((..((....((.....(..........)....))[))......(((.......(((.(.(..((....(((.....(([...((.....((.(((.....))).))......))......)).((((...((..(.......).))...))))((..(((((...(......)..)))))......)).(]((((.((((......)))))))))...)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)........((((...((............)).....))))....(.((..(...........)..))......)..((((([[....(.(.((.....((..]])).......)).)))))))..)))))...))..[......(.([[...(.(.((...(.(..(........(..(((.(........(..((.......)).((((...)..)))....).......).)))....)........(.((.(.(..((...............))..).).)).)....)....(((..(...(...(((...(((.((((((((...(..........)......)))))))).))).......((....))....)))..)...)...))..)).)...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.(((((....))))))))))).)..)))...((..]]))...))...].))))).).(((......((.(....).))....)))...]]].]((((..(((((((..((..((.((..(((..(((((.......(........)...........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....((..(((((....)))..(.((......)))...))..))....(((...(...((.(..((((((((((((.......)))).)))).....))))..).))..).....(((((.....)))))........)))....))).))).....).))))).....).)))))...)).)))..))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....((((............)))).....)..)..)).)).....((((((((.......))))))))......))...))))))).)).))..(.(..((.(..((((.((..(.((((((((.(((..((((.((...((((()))))...)).))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}........ Structure of the CNOT3-bound human 80S ribosome with tRNA-ARG in the P-site.; 18S rRNA 9c4g a 2903 2.53 RF02541 URS000268139D_1747 39122144 0003735 0005840 1747 caaaguuguguagugcgaucgguggaugccuuggcaccaagagccgaugaaggacguugugaccugcgauaagcccuggggaguuggugagcgagcugugauccggggguguccgaauggggaaaccuggaauguccggaguaguguccgguggcccugcccugaauguauaggggugugggugguaacgcggggaagugaaacaucuuaguacccguaggaagagaaaacaagugugauuccgugaguaguggcgagcgaaagcggaggaggcuaaaccgugugugugucagguguugcaugugcgggguugugggggccuugugguucugcugccgcaggauuggccagugagaaauguugcgugaaggugaagcgucugggaaggcguaccggagugggugagaguccuguaacuguaagcguggcacuggugugggguugccccgaguagcgugggacucguggaauuucgcgugaaucuggcgggaccacccgucaagccuaaauacuccuuggugaccgauaguggaugaguaccgugagggaagggugaaaaguaccccgggaggggagugaaagaguuccugaaaccggucgcaugcaagccgucagagccuguguggugauggcgugccuuuugaagaaugagccugcgaguuagugaugcguggcgagguuaacccguggugggggagucguagcgaaagcgaguccgauaagggcgugagucgcguguucuagacccgaagcggugugaucuauccauggccaggaugaagcgucgguaagacgucguggagguccgaacccacuucaguugaaaauggaggggaugaguuguggauaggggugaaaggccaaucaaacaccgugauagcugguucuccccgaaaugcauuuaggugcagcguugcgugguucuuguuggagguagagcacuggauggucuagggggcuuaucggcuuaccgaaaucagccaaacuccgaaugcuggcaaguguagcguggcagugagacggcgggugauaagcuucgucgucgagagggaaacagcccagaucaucagcuaaggccccuaaguggugacucagugggaaaggauguggaguugcguagacaaccaggagguuggcuuggaagcagccauccuugaaagagugcguaauagcucacuggucaagugauuccgcgccgauaauguagcggggcuuaaguuauccgccgaagcuguggcaaccugugugguuggguaggggagcgucgugucaguggugaagcugccgggugacugugugguggaguugaugcgagugagaaugcaggcaugaguagcgugugacgggugggaaucccguccgccgauuauccaaggguuccagggucaaguuugucugcccugggugagucggguccuaaggcgaggccgacaggcguagucgauggguaaccaguugauauucugguaccggcuugucaccgcaagcugcggagggacgcagugagguagcucauccccggugaugguuguccggggcuaaguguguggacugucugguagguaaauccgcugggcgugaagguugaggcaugauggggagcccaugguugugggugagugagugauccuguacugucgagaaaagcuucgugagcgagguggcggguccgcccguacccuaaaccgacacugguggauagguagaguauaccgaggcgaucgagugaaucguggugaaggaacucggcaaaaugcccccguaacuuugggauaagggggaccugagcugucgugcacccgugcggugugguggcggugaggggcgcagaguccagggggaaacgacuguuuaccaaaaacacagguccgugcgaagucguaagacgauguauacggacugacuccuncccggugcuggaagguuaaggggaacugugaguguaugcguagcggugaacuuaagccccaguaaacggcggugguaacnauaaccauccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggaguaacgauuucccuacugucuccaccaugaacucggugaaauugcauuacgaguaaagaugcucguuacgcgcagcaggacggaaagaccccgggaccuuuacuauaguuugguauuggugauugggacgguuuucugauuguucugguuaucucacuguggaccgugauccgguucaaggacagugccugauggguaguuugacugnggcggucgccuccuaaaggguaacggaggcgcccaaagguucccucagccugguugguaaucagguggugaguguaagugcacaagggggcuugacugugagacugacaggucgagcagggacgaaagucgggacuagugaucugacgguggcuuguggaugcgccgucacucaacggauaaaagguaccccgngganaacaggcugaucuugcccgagcgcucauagcgacggcaugguuuggcancucgnugucggcucgucgcauccuggggcuggagucggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucccuauccgcugcgcgcggaggaaucuugagaagggcugucuuuaguacgagaggaccgagacggacugaccucuggugugccaguuguucugccaagagcauggcugguuggcuacgucggguugugauaaccgcugaaagcaucuaagcgggaagcacgcuucaagauaaggguucccacaggaguguuccugguaagguccccgagagaugaucggguugauaggccagacguggacgcaucguaagguguggagcugacugguacuaauagaccgaggacuuuca ..<<<.......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<...<<)))....>>.......>>>>>>>...>>>....<<<....>>>.......<<<<<......>>>>>..<<<<.<<<<<.........>>>>>..>>>>>>...<<<<<<.....<<....>>......>>>>>.>.........<<<..>>>..<<<<<<.....<<.....>>....>>>>>>..<<<....<<<<......................>>>>......<<<<<<<<<......<<<<....>>>>..................<<..<<<...<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>......>>>..>>......>>>>>..>>>>.....<<<<<<<<.........>>>>>>>>.......<<<<..<<<<>>>>...>>>......]].>>>>>>>.]]...............<<....>>....]].........<<<<....>>>>..................>>>>>>>>>>>.......<<<<..<<<.....>>>..>>>>...<.<........>.>.<<<<<<....<<<.<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<.<<......>>.>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<....<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>>>....>>>>>>>.>>..<<<<<<<<<........>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<...<<<.........>>>...>>.........<<......>>...>>>>>....>>>>>>>>>.>>...........)))......>>>>>>.>>>...>>>>>>><<<<<.....>>>>>....>>>>>>..<<<<<<<<<.......<<<<<<<<....>>>.>>>>>....>>>>>>>>>........>>>>>><......<<....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<.<<..<..<....<<<<<<<<<....<<<<..<<<..<<<<<.<<<<<<...((((...>>>>>><<..<<<<...<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>...>>>>...>>....<<.........>>.....>>>>>...>>>...>>>>.........>>>>>>.>>>...>..>..>>.>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<<...<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>>.<<<..<<<<<<<.....<......>.....>>>>>>>..>>>.............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<..<<....>>...>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>>>>>>>>.....>.((..<<<<<......))>>>>>..<<<<<<<<.(((.[[......<<<<<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<........>>>>>>>>>>>>>>...<<.<<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<.<<<<<..<<.......>>>..>>>>.>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<..<<<<<<<<<<<<))))>>>>>>..>>>>>>..>>>>.>>>>>..<<<<....<<<<<...........>>>>>....>>>>>>>>.......>>>>>>>..<<<<<....>>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>...>>>>......>>>.. ..((........((((((((((.....(((..(((((((((((((......((((((....[[[.))).....((((((......]]]..............))))))...)))....(((....))).(.....(((((......))))))..(((.(((((.........)))))..))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...(((........................)))....(.(((((((.(.......(((....)))...................((........(((...(((((......)))))[[(...).(((.....]])))...)))...........))......).)))..))))]....((((((((..[......))))))))....).(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.((((..(((.....)))..)))).<.(.(........).).((((((....(((.((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((.((......)).)))...)[)))...(((.(((((.......A))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((..((((((((((.....(((...(((.((((...((.(((......)))..))...)))).)))..)).).....)))))))).).)))))))).))..(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{..((((.(.(..(((.........)))...)).....(...((......)).).))))....)))))))))).))...........]]].)....))))))))))...)))))))(((((.....)))))....))))))(.((((((.(((......((((((((....))).)))))...))).))))))..).....))))))(......((....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((.(.(((...(((....)))...)))..)))...(((((........)))))]](((.((..(..(....((.((((((....(((((.(((..(((.(.(((((((...{{{.).))))))((..((((...(((((((((((.((.....))))))))).....))))...))))...))....((.........)).....).)))...)))..)))))(..).....))))))..))...)..)..)).))))))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....))))).(((...(((((....................)))))...))).(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((..((....))...)))))...))...))))))))..)))))(.(((.........))).)........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....))[[..(((((.....>]])))))..((((((((.(((.((......((((((((((..(((((.(((.(((((.(((((((((.(..............).)))))))))...((.(((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.(.((((...((.......))...)))).)...).)).).)......(.((.((((((..((((.((((......)))).)..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..a.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((..((((((((((((}}}.))))))..))))))..)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..((((......))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...)))).......)).. Cutibacterium acnes 50S ribosomal subunit with Clindamycin bound; 23S rRNA 9c4g b 120 2.53 RF00001 URS0000F006E4_1747 39122144 0003735 0005840 1747 uuuccgguggccauaguggaagggaaacacccggucccauuccgaacccggucguuaagccuuccaacgcugaugguacugcacgagggaucgugugggagaguaagacgcugccggaau .<<<<<<<<<<....<<<<<<<<.....<<<<<<.............>>>>..>>....>>>>>>.>>.<<.......<<<<<<<<....>>>>>>>>.......>>..>>>>>>>>>>. .((((((((((....((((((((.....((((((...(.....)...))))..))....)))))).)).((.......((((((((....)))))))).......))..)))))))))). Cutibacterium acnes 50S ribosomal subunit with Clindamycin bound; 5S rRNA 9c8k 1 1708 3.1 RF01960,RF02542,RF01959,RF00177 39893634 0003735 0005840 9986 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucagaucaaaaccaacccgggcuuuggugacucuagauaaccucgggccgaucgcacgccccccguggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcggccccuugccucucgcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgacccccgagcgguaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccguggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<....[[[>>>>>[[[.((((((.....{{.........[[[.[[[...<.....<.....<..........>...>...>.......{{........[[[......{{....[[[{.....<<.....<<.<<.......>>.>>......>>.........<<<<...<<<<<<....>>>>>>...>>>>[[..(((((.....<<<<<<<<<<<.>>..............)))))......]]...<<<<..<<<......>>>.>>>>..}.]]]...}}....]]].<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<......>.>...]]]]]].........<<<....<<<.....>>>..>>>......}}.......<<<<<<<<<.<<<....>>>..>>>>>.>>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..)))))).]]]............{{.......{{...[[[.[[....<<<.....>>>....<.<..<....>>.>..<.<<<<<.<.......<<...<.......>.<<<<.......>>>>...>>......>.>>>..>>>..............((((((.....>>>>>>>>>.))))))..........]]....<<<<<<......<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>.....>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<........>>>>>>>>>.>..>>>...<<..}}>>...>>.....>>>.....<<<......<<<......>>>....>>>..]]]....<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<........<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<<<<<<<<....<<<.<<<<......>>....<<......>>....>>.>>>....<<<...<.<.<<<<..<<<<..<<..<......>..>>>>>>..>>>>.>>.....<<<<<.....>>>>>........>>>....>>>.>>>...>.>>>>>>>.....>.>>>>>......>>>>.>>>.....<<.<<<........<........<<.<<<<....>>>>.>>.....>.........>>>.>>............<<<<<..........>>>>>...........>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>........<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<.<<<<<..>>>>>...>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>..........<<<<<<<<....>>>>>>>>.......... ...((((..[...[..))))(((.((((((...(.((..((.....(((.(((...(....(.....((..........))....){)........((.......(((.(....(.....(((......((......(..((.....))..).......))..........(((...(.((((....)))).)...)))..(..(((((......[[[[[[[[((.)).....(.....)..)))))......)..(.((((.((((......)))))))))...)))....)..).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))..((.(.(..........).).)).(.((....)).)...)))))).).......(((.....((.}...))...)))..)...)).).....(..((((((.(((....)))..))))).)..)......((..(...........)..)).........((((([.....(.((((.....((...])).......))))))))))..)))))).))).........(.({{...(.(.((...(((..(.....((.....)).....(.(..((..))).)....(.(((.(.......((..............(((.......)))....))......).)))...)............(.(.((.((.....]]]]]]]]..)).)).)..)......)....(((..(.(.(...((((..((..((((((((...(..........)......))))))))..)).......((....))...))))..)..))...))..))))...)).)....((.(((....(...((((.........))))...).))).))......<...(((.((.(((..(.((((((.((..........)))))))).)..)))...((..}}))...)).....))))).).(((.......(((....))).....)))...]...](.(((.(((((((......(((((...(..((((((......((........))..........(((((.(....(((..........((.(((........))).))........)))...((.((....(.((((((....((..((..............(........)....))..)).....((...(.(.(.((...(((..((..(......)..)))))...)).)).).....(((((.....)))))........)).....))).))).....)..)))).....).)))))...)).))))..)..(...((.(.(........(........((.((((....)))).)).....).........).).))......(.....(((((..........))))).....)..)..))))).....((.(((((.......))))).))...........))))))))))..)..(.(..((.(..((((.((..(.((((((((.(.....(((.((...(((((.(((((..)))))...)))))...)).)).)....).)))))))))..)).))))...).))...)..)....(((((((....)))))))..>........ Rabbit Hemorrhagic Disease Virus reinitiation stimulating TURBS RNA bound to rabbit ribosome; 18S ribosomal RNA 9c8k 2 27 3.1 39893634 11976 gcccugugggacccaggccuggggggc <<<<.......<<<<<<>>>>>>>>>> ((((.......(((((()))))))))) Rabbit Hemorrhagic Disease Virus reinitiation stimulating TURBS RNA bound to rabbit ribosome; RHDV Reinitiation stimulating element RNA 9cai DA 76 2.59 RF00005 39209556 0030533 6239 gccucgauagcucaguugggagagcguacgacugaagaucguaaggucaccaguucgauccugguucggggcacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((.(((..((((.....[..)))).(((((.......))))).....(((((..]....)))))))).))).... High-resolution C. elegans 80S ribosome structure - class 1; tRNA 9cai A7 119 2.59 RF00001 39209556 0003735 0005840 6239 gcuuacgaccauaucacguugaaugcacgccaucccguccgaucuggcaaguuaagcaacguugaguccaguuaguacuuggaucggagacggccugggaauccuggauguuguaagcu <<<<<<<<<....<<<<<<<<.....<<<<<<............>>>>..>>....>>>>>>.>><<<<<<......<<.<<..<<....>>.>>.>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))). High-resolution C. elegans 80S ribosome structure - class 1; 5S rRNA 9cai A8 146 2.59 RF00002 39209556 0003735 0005840 6239 uagcuucagcgauggaucgguugcaucgaguaucgaugaagaacgcagcuugcugcguuacuuaccacgaauugcagagaguggugaaauuucgaacgcauagcaccaacugggccuccaguugguacgucugguucaggguuguu ........................................<<<<<<.((.....>>>.....<<<<<<.....)).....>>>>>.>...>>>....<<...>><<<<<<<<<....>>>>>>>>>.................... ........................................((((((.[[.....))).....(.((((.....]].....))))..)...)))....((...))(((((((((....))))))))).................... High-resolution C. elegans 80S ribosome structure - class 1; 5.8S rRNA 9cai B2 1476 2.59 RF01960,RF02542,RF01959,RF00177 39209556 0003735 0005840 6239 uaccugauugauucugucagcgcgauaugcucaaguaaaagauuaagccaugcaugcgauucauugaaauugcguacggcucauuagagcagauaucaccuuauccgggauggauaacugcggaaauacuggagcuaauacaugcaccccagcggggugcaauuauuaguguugacucugaauaaagcaguuuacugucagcugacucuauccggaaagggugucugcccuuucaacuagaugguaguuuauuggacuaccaugguuguuacggguaacggagaauaaggguucgacuccggagagggagccuuagaaacggcuaccacguccaaggaaggcagcaggcgcgaaacuuauccacuguuguaugagauagugacuaaaaauauaguugaauacaaaugauucuucgaggagagggcaagucuggugccagcagccgcgguaauuccagcucuccuaguguaucucguuauugcugcgguuaaaaagcucguaguuggaucuagguuuaccuugaauaaaucagagugcucaauacaagcgcuugcuugaauagcaucauggaauaaugaaauuaaugguuaagagggacaaaccgggggcauucguaucauuacgcgagaggugaaauucguggaccguagugagacgcccaacagcgaaagcauuugccaagaaugucuucauuaaucaagaacgaaagucagagguucgaaggcgauuagauaccgcccuaguucugaccguaaacgaugccaucucgcgauucggagggugcccugccgaggagcauccggaaacgaaagucuuucgguuccggggguaguaugguugcaaagcugaaacuuaaagaaauugacggaagggcaccacaaggcguggagcuugcggcuuaauuugacucaacacgggaaaacucacccgguccggacaccaugacugacagauugaaagcucuuucucgauuuggugguugguggugcauggccguucuuaguugguggagugauuugucugguuuauuccgauaacgagcgagacucuagccucuaaauaguuggcgaaucuucggguucguuaacuucuuagagggauaagcgguguuuagccgcacgagauugagcgauaacaggucugugaugcccuuagauguccggggcugcacgcgugcuacacugguggagucagcggguccuaugccgaaagguaucgguaaaccguugaaauucuuccauguccgggauaggguauuguaauuauugcccuuaaacgaggaaugccuaguaagugugagucaucagcucacguugauuacgucccugcccuuuguacacaccgcccgucgcuauccgggacugaacugauucgagaagaguggggacugugcggaaaccauuuuuaucgcauugguuugaaccggguaaaagucguaacaagguagcuguaggugaaccugcagcuggaucaucg ...<<<<<.[.((((>>>>><<.<<<<<<<.....<<..<......<<<.<<<..<<<<<<......>>>>>>......<<.......<<<<<<<<..<<<..<<<<<..<<.....<<.<<<.....>>>.>>......>>...<<<<<...>>>>><<..<<<<<...<......>..>>>>>....>>.....<<<<..>>>>.....>>>>>.>>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<.....>..>>>..>...>>........<..<<<<.......>>>>..>..<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>>.>>.........<<<((.....<.<<...<<<.<<.......<<<<<.<<<.......<..<<.......>>.<<<....>>>....>....>>>.>>..>>>............>>....<<<<<<...<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<..<..<<..<<<<<<<<<..>>>>.>>>>>..>>...<<..))>>...>......>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<.....<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<......>>...<<<......>>>...>>.>>>....<<<...<<<<<<<..<<<<<<<<<<<<....>>>>>>>>>>>>..>>>>>>>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<.<<<<......<<.<<.<<<<<....>>>>>.>>....>>.......>>>>.>>......<....<<<<<<..........>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<<<<....<<<<<<<<.<<<.<<<<<<<<...<<<..>>>...>>>>>>>>.>>>.>>>>>>>>...>>>>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))((.(((((((.....((..((.....(((.(((..(((((........)))))......(((.......((((((...(((..((((((.((.....((.(((.....))).))......))...(((((...)))))((..(((((...(......)..)))))....)).....((((()))))....)))))).))).)))))).(((....(((..((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...(((...)).))))).)...))........(..(((.........)))..)..((((([[....(.((((.....((..]])).......))))))))))..))))))).))..[......((([[...(.(.((...(((..(.......(((((.(((..........((.......))..((....))..........))).))..)))............)....(((..((...(...((((..((..((((((((...((........))......))))))))..)).......((....))...))))..)..))...))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((..(..((..(((((((((())))).)))))..))...((..]]))...)....].))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....((.(((........))).))......)))))...((.(((...(.((((((....(((.(((((....)))....((......))....)).)))....(((...(((((((..(((((((((((......)))))))))))..))))))).....(((((.....)))))........)))....))).))).....).))))).....).)))))...)).)))).))).(...((.(((.......((.((..((((....))))..))....))........))).))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).))..(.(..((.(..(((((((..(.((((((((.(((..(((((((...(.(()).)...)))))))..))).)))))))))..)))))))...).))...)..)..(((((((((....)))))))))}........ High-resolution C. elegans 80S ribosome structure - class 1; 18S rRNA 9cai A5 3022 2.59 RF02540,RF02541,RF02543 39209556 0003735 0005840 6239 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.........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..(((((.(((((...)))))..))))....)))).....((.((((((..(((((((((((((.(((((...({((((......)))))......[(...).(((....}].))).....))))))))))))))))))...)))))).))...)....(((((((........))))))).....(((((..[[[[..)))))..)))..................................((....))............(..((((....))))............).....................(((((((.((((((.)((((((((((((((((((((((..((.(((((.((((...(().)..)))).)))..)).))..)).)))))))))))).))))))))......)))))...))))))).<((((........))))((((((....(.(((((.(((((..(((...(((........)))...)))...((....))...(((((((.....)))))))..(((((...(((((..)))))....)))))(((((((((..(((((..))))).)))))).)))...))))).))))).)..((.(...((((((.....((((((((((.(((....(((((((....)))))))....<)))...(((..((.((........)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((((((((((..(((.((((((((.....((....(((..(.(((..))).)..)))..))......))))))...(((((((((.(......)))))).))))...))))))))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{....)))))))))))))..........]]].)....))))))))))...)))))))(((((((((...)))))))))....)))))).(.((((((..((......((((((((....))))))))...))..))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...((((((...((.....)).))))))....[[(((.((...(((...(((....))).........(((.(((.))).)))...)))....))...(((((........)))))]]((((.((((((..(((((())))))(((((....)))...(.[[((((((..((((.(((((((((((((((((....{{...)))))(...(((((....(((((.....(((.....))).....)))))....))).))....)((((((..)))))))))).).))))))).)))).........))))))...)))......)))))))))).)))..)).....((......)).)))).((((.....))))..))))..((((.....((((.((.((..(....(.......(((((....(.[..).....)))))((.(((((((((.)))..)))))).))(...)(....).(((((((((.>.((.........))...(((((((....((((....))))......))))))).].(((.(((..((((((.....((....(((.(....).)))....))..))))..)))))(((((.........)))))........((.(......).((((.(.....).))))..)..)....)))....)).))))))).)..))).)).))))..))))))....)).[..(((((.....>].)))))....((.((..(((.((......((((.((((((..(((((.(((((((((.((((((((((.))))))))))...(((((.....((((............]]..((((.(((((.))))).))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....(((((.(.((((...]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))....))..))).)).))......((.((((..(((..(.(((((......(....).....))))).)((((....(((.....((((((((((}}..)))))..)))))....)))...)))).((((...((((.....}.......))))...))))..)))......)))).))....((.(((((((((.((..(((.......(((((((....)))))))......)))....(..((((...(((((((.((.....)).))))))).))))...)..............)).))))))))).)).(((...(..(.......)..).(((((((((.(((.....(((.(..(((((........)))))..))))....)))...))).))))))...))).. High-resolution C. elegans 80S ribosome structure - class 1; 28S rRNA 9cai DC 10 2.59 39209556 6239 uuuuuuuuuu .......... .......... High-resolution C. elegans 80S ribosome structure - class 1; mRNA 9cg5 A 1519 2.59 RF00177,RF01959,RF02542,RF01960 39222680 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugccggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<......>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<.>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<..>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<..<.<<<<<<<........>>>>>>>>...>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((.(........).))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((.)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((((())))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))...(......)..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... 70S initiation complex (tRNA-fMet M1 + UUG start codon); 16S ribosomal RNA 9cg5 Z 75 2.59 RF00005 39222680 0030533 562 gcgggguggagcagccgguagcucgucgcgcucauaacgcgaaggucgucgguucaaauccggcccccgcaacca <<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((.....[..)))).(((((.......))))).....(((((..]....)))))))))))..... 70S initiation complex (tRNA-fMet M1 + UUG start codon); P-site tRNA-fMet M1 9cg5 a 2753 2.59 RF02540,RF02541,RF02543,RF00002 39222680 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagcgucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcgcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<..>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<..>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<<.<<....>>..>>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<..>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))..(((((((..((((((((((.....(((...(((.((((...(((.(((.....))).).))...)))).)))..)).).....)))))).)))..)))))))).....(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(())...)))..))))).))...........]]].)...))))))))))...)))))))((((((((()))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((())))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..)))))).......(((..(.((((((...((.......))...))))))...).)).).......((.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..))....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). 70S initiation complex (tRNA-fMet M1 + UUG start codon); 23S ribosomal RNA 9cg5 b 119 2.59 RF00001 39222680 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>> ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))) 70S initiation complex (tRNA-fMet M1 + UUG start codon); 5S ribosomal RNA 9cg6 A 1519 2.61 RF00177,RF01959,RF02542,RF01960 39222680 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugccggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<...<<<<<<<<<......>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<.>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<..>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<..<.<<<<<<<........>>>>>>>>...>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((.(........).))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((.)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((((())))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((.(((....))).)))...(......)..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... 70S initiation complex (tRNA-fMet M1 + GUG start codon); 16S ribosomal RNA 9cg6 Z 75 2.61 RF00005 39222680 0030533 562 gcgggguggagcagccgguagcucgucgcgcucauaacgcgaaggucgucgguucaaauccggcccccgcaacca <<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((........)))).(((((.......))))).....(((((.......)))))))))))..... 70S initiation complex (tRNA-fMet M1 + GUG start codon); P-site tRNA-fMet M1 9cg6 a 2753 2.61 RF02540,RF02541,RF02543,RF00002 39222680 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagcgucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcgcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<....<.<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>..>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<..>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<..>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<..>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>.(<<...<<<<<<<...<<<<<<.......>>>>>>.....<<)..(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......((((.((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))).))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))..(((((((..((((((((((.....(((...(((.((((...(((.(((.....))).).))...)))).)))..)).).....)))))).)))..)))))))).....(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(())...)))..))))).))...........]]].)...))))))))))...)))))))((((((((()))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((())))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).).....((.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..))....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). 70S initiation complex (tRNA-fMet M1 + GUG start codon); 23S ribosomal RNA 9cg6 b 119 2.61 RF00001 39222680 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>> ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))) 70S initiation complex (tRNA-fMet M1 + GUG start codon); 5S ribosomal RNA 9cg7 A 1519 2.75 RF00177,RF01959,RF02542,RF01960 39222680 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugccggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<......>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<.>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<..>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((.(........).))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((.)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((((())))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((.(((....))).)))...(......)..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... 70S initiation complex (tRNA-fMet M1 + AUG start codon); 16S ribosomal RNA 9cg7 Z 75 2.75 RF00005 39222680 0030533 562 gcgggguggagcagccgguagcucgucgcgcucauaacgcgaaggucgucgguucaaauccggcccccgcaacca <<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((.....[..)))).(((((.......))))).....(((((..]....)))))))))))..... 70S initiation complex (tRNA-fMet M1 + AUG start codon); P-site tRNA-fMet M1 9cg7 a 2753 2.75 RF02540,RF02541,RF02543,RF00002 39222680 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagcgucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcgcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<..>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<..>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<<.<<....>>..>>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<..>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>.(<<...<<<<<<<...<<<<<<.......>>>>>>.....<<)..(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))..(((((((..((((((((((.....(((...(((.((((...(((.(((.....))).).))...)))).)))..)).).....)))))).)))..)))))))).....(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(())...)))..))))).))...........]]].)...))))))))))...)))))))((((((((()))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((())))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).).....((.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..))....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). 70S initiation complex (tRNA-fMet M1 + AUG start codon); 23S ribosomal RNA 9cg7 b 119 2.75 RF00001 39222680 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>> ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))) 70S initiation complex (tRNA-fMet M1 + AUG start codon); 5S ribosomal RNA 9cmp G 21 3.3 39229170 9606 uggaagacuagugauuuuguu ..................... ..................... Structure of human Argonaute2-guide-target complex in a fully paired, slicing-competent conformation; RNA (5'-R(P*UP*GP*GP*AP*AP*GP*AP*CP*UP*AP*GP*UP*GP*AP*UP*UP*UP*UP*GP*UP*U)-3') 9cmp T 22 3.3 39229170 9606 caacaaaaucacuagucuucca ...................... ...................... Structure of human Argonaute2-guide-target complex in a fully paired, slicing-competent conformation; RNA (5'-R(*CP*AP*AP*CP*AP*AP*AP*AP*UP*CP*AP*CP*UP*AP*GP*UP*CP*UP*UP*CP*CP*A)-3') 9cpd A 13 NA 39002937 9606 gacagcugcuguc ............. ............. Structures of small molecules bound to RNA repeat expansions that cause Huntington's disease-like 2 and myotonic dystrophy type 1; RNA (5'-R(*GP*AP*CP*AP*GP*CP*UP*GP*CP*UP*GP*UP*C)-3') 9cpd B 13 NA 39002937 9606 gacagcugcuguc ............. ............. Structures of small molecules bound to RNA repeat expansions that cause Huntington's disease-like 2 and myotonic dystrophy type 1; RNA (5'-R(*GP*AP*CP*AP*GP*CP*UP*GP*CP*UP*GP*UP*C)-3') 9cpg A 13 NA 39002937 9606 gacagcugcuguc ............. ............. Structures of small molecules bound to RNA repeat expansions that cause Huntington's disease-like 2 and myotonic dystrophy type 1; RNA (5'-R(*GP*AP*CP*AP*GP*CP*UP*GP*CP*UP*GP*UP*C)-3') 9cpg B 13 NA 39002937 9606 gacagcugcuguc ............. ............. Structures of small molecules bound to RNA repeat expansions that cause Huntington's disease-like 2 and myotonic dystrophy type 1; RNA (5'-R(*GP*AP*CP*AP*GP*CP*UP*GP*CP*UP*GP*UP*C)-3') 9cpi A 13 NA 39002937 9606 gacagcugcuguc ............. ............. Structures of small molecules bound to RNA repeat expansions that cause Huntington's disease-like 2 and myotonic dystrophy type 1; RNA (5'-R(*GP*AP*CP*AP*GP*CP*UP*GP*CP*UP*GP*UP*C)-3') 9cpi B 13 NA 39002937 9606 gacagcugcuguc ............. ............. Structures of small molecules bound to RNA repeat expansions that cause Huntington's disease-like 2 and myotonic dystrophy type 1; RNA (5'-R(*GP*AP*CP*AP*GP*CP*UP*GP*CP*UP*GP*UP*C)-3') 9cpj A 13 NA 39002937 9606 gacagcugcuguc ............. ............. Structures of small molecules bound to RNA repeat expansions that cause Huntington's disease-like 2 and myotonic dystrophy type 1; RNA (5'-R(*GP*AP*CP*AP*GP*CP*UP*GP*CP*UP*GP*UP*C)-3') 9cpj B 13 NA 39002937 9606 gacagcugcuguc ............. ............. Structures of small molecules bound to RNA repeat expansions that cause Huntington's disease-like 2 and myotonic dystrophy type 1; RNA (5'-R(*GP*AP*CP*AP*GP*CP*UP*GP*CP*UP*GP*UP*C)-3') 9cpo P 30 3.5 39091740 2697049 ucuccuaagaagcuauuaaaaucacagauu .............................. .............................. Infectious bronchitis virus core polymerase complex; RNA Primer 9cpo T 33 3.5 39091740 2697049 aaaaaucugugauuuuaauagcuucuuaggaga ................................. ................................. Infectious bronchitis virus core polymerase complex; RNA template 9d0j 1A 2871 2.5 RF02540,RF02541,RF02543,RF00002 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<.....<<<........>>>......>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..<<<.....(.>>>...>>>.........<<......>>.).>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<........<<<.<<....>>.>>>.....>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<...>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((..(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...((((((((.(...((..........))...)..))))))))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((..((.........))...))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(......[..(((((..(((.......((((.((....)).))))....)))..........].)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((...)))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with BT-33, mRNA, deacylated A-site tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.50A resolution; 23S Ribosomal RNA 9d0j 1B 120 2.5 RF00001 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> (((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).))))))))))) Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with BT-33, mRNA, deacylated A-site tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.50A resolution; 5S Ribosomal RNA 9d0j 1a 1500 2.5 RF00177,RF01959,RF02542,RF01960 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<..[.>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>.......]..<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<......>>....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((((((....))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((..((((....))))..))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((((((....)))))))....((......))....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with BT-33, mRNA, deacylated A-site tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.50A resolution; 16S Ribosomal RNA 9d0j 1v 13 2.5 2681598 aaaaauguucuaa ............. ............. Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with BT-33, mRNA, deacylated A-site tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.50A resolution; MF-mRNA 9d0j 1w 71 2.5 RF00005 URS00005AA258_562 0030533 0006412 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggca <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>. (.(((((..((((...[..)))).((((.........)))).....(((((..]....)))))))))).). Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with BT-33, mRNA, deacylated A-site tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.50A resolution; A-site and E-site Deacylated tRNAphe 9d0j 1x 76 2.5 RF00005 0030533 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaaccn <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with BT-33, mRNA, deacylated A-site tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.50A resolution; P-site Aminoacylated fMet-tRNAmet 9d0j 1y 74 2.5 RF00005 0030533 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[..)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with BT-33, mRNA, deacylated A-site tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.50A resolution; A-site and E-site Deacylated tRNAphe 9d0j 2A 2800 2.5 RF02540,RF02541,RF02543,RF00002 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<....<<............>.>....>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<..>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<.......<<<<<<<<....>>>>>>>>....>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...((((((((.....))))))))....{.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).))))....(((((((((.[.....)))))))))....}.(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((()))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((....((............).)....)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((((((()))))))))).))..........]]].)....))))))))))...)))))))(((((.(()).)))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(......[..(((((.....(.....((((((((....))))))))...)............].)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(((...)).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with BT-33, mRNA, deacylated A-site tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.50A resolution; 23S Ribosomal RNA 9d0j 2B 120 2.5 RF00001 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>>. .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with BT-33, mRNA, deacylated A-site tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.50A resolution; 5S Ribosomal RNA 9d0j 2a 1503 2.5 RF00177,RF01959,RF02542,RF01960 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggau .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<......>>....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>.........<.<<<<<<<........>>>>>>>>.........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((...((((((......))))))....(.(....).)....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((..((..(.((....)).)..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with BT-33, mRNA, deacylated A-site tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.50A resolution; 16S Ribosomal RNA 9d0j 2v 13 2.5 2681598 aaaaauguucuaa ............. ............. Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with BT-33, mRNA, deacylated A-site tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.50A resolution; MF-mRNA 9d0j 2w 69 2.5 RF00005 URS00005AA258_562 0030533 0006412 562 cccgganagcucagggagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggca <<<<<<..<<<<.....>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>.. ((((((..((((...[.)))).((((.........)))).....(((((..]....))))))))))).. Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with BT-33, mRNA, deacylated A-site tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.50A resolution; A-site and E-site Deacylated tRNAphe 9d0j 2x 76 2.5 RF00005 0030533 562 gcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaaccn <<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with BT-33, mRNA, deacylated A-site tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.50A resolution; P-site Aminoacylated fMet-tRNAmet 9d0j 2y 73 2.5 RF00005 0030533 562 gcccgganagcucagggagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<.....>>>>.<<<<<<<...>>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[.)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with BT-33, mRNA, deacylated A-site tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.50A resolution; A-site and E-site Deacylated tRNAphe 9d5j C 32 2.8 URS0002617743_9606 39456162 9606 gcucgcgaugcgngagggcucugauagcuacg ................................ ................................ Human Adenosine Deaminase Acting on dsRNA (ADAR2-RD) bound to dsRNA containing deoxyinosine at the -1 position of the guide strand; RNA Top Strand Containing 8-azanebularine (8AZ) 9d5j D 32 2.8 39456162 9606 cguagcuaucagagccccccigcaucgcgagc ................................ ................................ Human Adenosine Deaminase Acting on dsRNA (ADAR2-RD) bound to dsRNA containing deoxyinosine at the -1 position of the guide strand; RNA Bottom Strand containing deoxyinosine complementary to a guanosine adjacent to the target site 9d5k C 32 2.697 URS0002617743_9606 39456162 9606 gcucgcgaugcgngagggcucugauagcuacg ................................ ................................ Human Adenosine Deaminase Acting on dsRNA (ADAR2-RD) bound to dsRNA containing an expanded cytidine analog at the -1 position of the guide strand; RNA Top Strand 9d5k D 32 2.697 URS0002617724_9606 39456162 9606 cguagcuaucagagccccccngcaucgcgagc ................................ ................................ Human Adenosine Deaminase Acting on dsRNA (ADAR2-RD) bound to dsRNA containing an expanded cytidine analog at the -1 position of the guide strand; RNA Bottom Strand 9d7r 1A 2871 2.7 RF02540,RF02541,RF02543,RF00002 39415050,39415050 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..<<<.......>>>...>>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((..(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((.(.((((..........)).)))..)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((..((.........))...))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((.(((((((((.(......[..(((((..(((......((((((((....))))))))...)))..........].)))))).))))))))).))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..(((...)))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with Fva1 antimicrobial peptide, mRNA, A-site release factor 1, and deacylated P-site and E-site tRNAphe at 2.70A resolution; 23S Ribosomal RNA 9d7r 1B 120 2.7 RF00001 39415050,39415050 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> (((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).))))))))))) Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with Fva1 antimicrobial peptide, mRNA, A-site release factor 1, and deacylated P-site and E-site tRNAphe at 2.70A resolution; 5S Ribosomal RNA 9d7r 1a 1500 2.7 RF00177,RF01959,RF02542,RF01960 39415050,39415050 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<......>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>...<.<......>>....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<..<.<<<<<<<........>>>>>>>>...>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((((((.().))))))).)))))......(((......((((((((..((...(((((((.(((((....(((..........))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((........))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((.(((....))).)))....(((....)))....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with Fva1 antimicrobial peptide, mRNA, A-site release factor 1, and deacylated P-site and E-site tRNAphe at 2.70A resolution; 16S Ribosomal RNA 9d7r 1v 13 2.7 39415050,39415050 2681598 guaaaauucuaau ............. ............. Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with Fva1 antimicrobial peptide, mRNA, A-site release factor 1, and deacylated P-site and E-site tRNAphe at 2.70A resolution; PHE-Stop mRNA 9d7r 1x 75 2.7 RF00005 39415050,39415050 0030533 562 gcccgganagcucagucgguagagcaggggauugaanauccccgnuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((.........))))....(((((..]....)))))))))))).... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with Fva1 antimicrobial peptide, mRNA, A-site release factor 1, and deacylated P-site and E-site tRNAphe at 2.70A resolution; P-site and E-site Deacylated tRNAphe 9d7r 1y 74 2.7 RF00005 39415050,39415050 0030533 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[..)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with Fva1 antimicrobial peptide, mRNA, A-site release factor 1, and deacylated P-site and E-site tRNAphe at 2.70A resolution; P-site and E-site Deacylated tRNAphe 9d7r 2A 2800 2.7 RF02540,RF02541,RF02543,RF00002 39415050,39415050 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<..........>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<..>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> .((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...((((((((.....))))))))....{.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).))))....(((((((((.[.....)))))))))....}.(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((()))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((.(((...(((...(((.((((.(.((((.(......).)).)))..)))).)))..)).)...))).)))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((((((()))))))))).))..........]]].)....))))))))))...)))))))(((((((())))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(......[..(((((..(((.......(((((((....)))))))....)))..........].)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(............(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...))). Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with Fva1 antimicrobial peptide, mRNA, A-site release factor 1, and deacylated P-site and E-site tRNAphe at 2.70A resolution; 23S Ribosomal RNA 9d7r 2B 120 2.7 RF00001 39415050,39415050 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> (((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).))))))))))) Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with Fva1 antimicrobial peptide, mRNA, A-site release factor 1, and deacylated P-site and E-site tRNAphe at 2.70A resolution; 5S Ribosomal RNA 9d7r 2a 1503 2.7 RF00177,RF01959,RF02542,RF01960 39415050,39415050 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggau .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<......>>....>>>>>>>.<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((((((....))))))).(..(((....)))..).)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.(.((....)).)).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with Fva1 antimicrobial peptide, mRNA, A-site release factor 1, and deacylated P-site and E-site tRNAphe at 2.70A resolution; 16S Ribosomal RNA 9d7r 2v 13 2.7 39415050,39415050 2681598 guaaaauucuaau ............. ............. Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with Fva1 antimicrobial peptide, mRNA, A-site release factor 1, and deacylated P-site and E-site tRNAphe at 2.70A resolution; PHE-Stop mRNA 9d7r 2x 75 2.7 RF00005 39415050,39415050 0030533 562 gcccgganagcucagucgguagagcaggggauugaanauccccgnuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((.........))))....(((((..]....)))))))))))).... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with Fva1 antimicrobial peptide, mRNA, A-site release factor 1, and deacylated P-site and E-site tRNAphe at 2.70A resolution; P-site and E-site Deacylated tRNAphe 9d7r 2y 74 2.7 RF00005 39415050,39415050 0030533 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<......>>>>.<<<<<<<...>>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[..)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with Fva1 antimicrobial peptide, mRNA, A-site release factor 1, and deacylated P-site and E-site tRNAphe at 2.70A resolution; P-site and E-site Deacylated tRNAphe 9d7s 1A 2871 2.85 RF02540,RF02541,RF02543,RF00002 39415050,39415050 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..<<<.......>>>...>>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<.<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>.>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((..(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...((((((((.(.((.(..........)..)))..))))))))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((..((.........))...))).....(....(......)..).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........(((((..(((......(((((.((....)).)))))...)))............)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..((((.))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with Api antimicrobial peptide, mRNA, A-site release factor 1, and deacylated P-site and E-site tRNAphe at 2.85A resolution; 23S Ribosomal RNA 9d7s 1B 120 2.85 RF00001 39415050,39415050 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> (((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).))))))))))) Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with Api antimicrobial peptide, mRNA, A-site release factor 1, and deacylated P-site and E-site tRNAphe at 2.85A resolution; 5S Ribosomal RNA 9d7s 1a 1500 2.85 RF00177,RF01959,RF02542,RF01960 39415050,39415050 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<......>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<......>>....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((())))))))).)))))......(((......((((((((..((...(((((((.(((((....(((((.....).)))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((........))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((((((....)))))))....(((....)))....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with Api antimicrobial peptide, mRNA, A-site release factor 1, and deacylated P-site and E-site tRNAphe at 2.85A resolution; 16S Ribosomal RNA 9d7s 1v 13 2.85 39415050,39415050 2681598 guaaaauucuaau ............. ............. Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with Api antimicrobial peptide, mRNA, A-site release factor 1, and deacylated P-site and E-site tRNAphe at 2.85A resolution; PHE-Stop mRNA 9d7s 1x 75 2.85 RF00005 39415050,39415050 0030533 562 gcccgganagcucagucgguagagcaggggauugaanauccccgnuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((.........))))....(((((..]....)))))))))))).... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with Api antimicrobial peptide, mRNA, A-site release factor 1, and deacylated P-site and E-site tRNAphe at 2.85A resolution; P-site and E-site Deacylated tRNAphe 9d7s 1y 74 2.85 RF00005 39415050,39415050 0030533 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((......)))).((((.........)))).....(((((.......)))))))))))).... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with Api antimicrobial peptide, mRNA, A-site release factor 1, and deacylated P-site and E-site tRNAphe at 2.85A resolution; P-site and E-site Deacylated tRNAphe 9d7s 2A 2800 2.85 RF02540,RF02541,RF02543,RF00002 39415050,39415050 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>..<....<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<..........>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<..>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<....>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>>.<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...((((((((.....))))))))....{.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).))))....(((((((((.[.....)))))))))....}.(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((()))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((.(..(((..........)).).)..)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((((((()))))))))).))..........]]].)....))))))))))...)))))))(((((((())))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(......[..(((((..(((.......(((((((....)))))))....)))..........].)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.((((...........))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))((((.))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with Api antimicrobial peptide, mRNA, A-site release factor 1, and deacylated P-site and E-site tRNAphe at 2.85A resolution; 23S Ribosomal RNA 9d7s 2B 120 2.85 RF00001 39415050,39415050 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> (((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).))))))))))) Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with Api antimicrobial peptide, mRNA, A-site release factor 1, and deacylated P-site and E-site tRNAphe at 2.85A resolution; 5S Ribosomal RNA 9d7s 2a 1503 2.85 RF00177,RF01959,RF02542,RF01960 39415050,39415050 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggau .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<<....>>>....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((((((....))))))).(..(((....)))..).)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.(.((....)).)).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with Api antimicrobial peptide, mRNA, A-site release factor 1, and deacylated P-site and E-site tRNAphe at 2.85A resolution; 16S Ribosomal RNA 9d7s 2v 13 2.85 39415050,39415050 2681598 guaaaauucuaau ............. ............. Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with Api antimicrobial peptide, mRNA, A-site release factor 1, and deacylated P-site and E-site tRNAphe at 2.85A resolution; PHE-Stop mRNA 9d7s 2x 75 2.85 RF00005 39415050,39415050 0030533 562 gcccgganagcucagucgguagagcaggggauugaanauccccgnuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((.........))))....(((((..]....)))))))))))).... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with Api antimicrobial peptide, mRNA, A-site release factor 1, and deacylated P-site and E-site tRNAphe at 2.85A resolution; P-site and E-site Deacylated tRNAphe 9d7s 2y 74 2.85 RF00005 39415050,39415050 0030533 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<......>>>>.<<<<<<<...>>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[..)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with Api antimicrobial peptide, mRNA, A-site release factor 1, and deacylated P-site and E-site tRNAphe at 2.85A resolution; P-site and E-site Deacylated tRNAphe 9d7t 1A 2871 2.7 RF02540,RF02541,RF02543,RF00002 39415050,39415050 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..<<<.......>>>...>>>..........<......>....>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<.<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>.>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((..(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((.(.((((..........)).)))..)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((..((.........))...))).....(....(......)..).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(.........(((((..(((......(((((.((....)).)))))...)))............)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((.))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with Api137 antimicrobial peptide, mRNA, A-site release factor 1, and deacylated P-site and E-site tRNAphe at 2.70A resolution; 23S Ribosomal RNA 9d7t 1B 120 2.7 RF00001 39415050,39415050 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> (((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).))))))))))) Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with Api137 antimicrobial peptide, mRNA, A-site release factor 1, and deacylated P-site and E-site tRNAphe at 2.70A resolution; 5S Ribosomal RNA 9d7t 1a 1500 2.7 RF00177,RF01959,RF02542,RF01960 39415050,39415050 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<......>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<......>>....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((((((.().))))))).)))))......(((......((((((((..((...(((((((.(((((....(((.(.....)..))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((........))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((((((....)))))))....(((....)))....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with Api137 antimicrobial peptide, mRNA, A-site release factor 1, and deacylated P-site and E-site tRNAphe at 2.70A resolution; 16S Ribosomal RNA 9d7t 1v 13 2.7 39415050,39415050 2681598 guaaaauucuaau ............. ............. Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with Api137 antimicrobial peptide, mRNA, A-site release factor 1, and deacylated P-site and E-site tRNAphe at 2.70A resolution; PHE-Stop mRNA 9d7t 1x 75 2.7 RF00005 39415050,39415050 0030533 562 gcccgganagcucagucgguagagcaggggauugaanauccccgnuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((.........))))....(((((..]....)))))))))))).... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with Api137 antimicrobial peptide, mRNA, A-site release factor 1, and deacylated P-site and E-site tRNAphe at 2.70A resolution; P-site and E-site Deacylated tRNAphe 9d7t 1y 74 2.7 RF00005 39415050,39415050 0030533 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[..)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with Api137 antimicrobial peptide, mRNA, A-site release factor 1, and deacylated P-site and E-site tRNAphe at 2.70A resolution; P-site and E-site Deacylated tRNAphe 9d7t 2A 2800 2.7 RF02540,RF02541,RF02543,RF00002 39415050,39415050 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<..........>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<..>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<..>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<....>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...((((((((.....))))))))....{.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).))))....(((((((((.[.....)))))))))....}.(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((()))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((.(..(((.(......).)).).)..)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((((((..))))))))).))..........]]].)....))))))))))...)))))))(((((((())))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((((((((((((.(......[..(((((..(((.......(((((((....)))))))....)))..........].)))))).))))))))))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.((((...........))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))((((.))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with Api137 antimicrobial peptide, mRNA, A-site release factor 1, and deacylated P-site and E-site tRNAphe at 2.70A resolution; 23S Ribosomal RNA 9d7t 2B 120 2.7 RF00001 39415050,39415050 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> (((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).))))))))))) Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with Api137 antimicrobial peptide, mRNA, A-site release factor 1, and deacylated P-site and E-site tRNAphe at 2.70A resolution; 5S Ribosomal RNA 9d7t 2a 1503 2.7 RF00177,RF01959,RF02542,RF01960 39415050,39415050 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggau .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<......>>....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((((((....)))))))....(((....)))....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.(.((....)).)).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with Api137 antimicrobial peptide, mRNA, A-site release factor 1, and deacylated P-site and E-site tRNAphe at 2.70A resolution; 16S Ribosomal RNA 9d7t 2v 13 2.7 39415050,39415050 2681598 guaaaauucuaau ............. ............. Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with Api137 antimicrobial peptide, mRNA, A-site release factor 1, and deacylated P-site and E-site tRNAphe at 2.70A resolution; PHE-Stop mRNA 9d7t 2x 75 2.7 RF00005 39415050,39415050 0030533 562 gcccgganagcucagucgguagagcaggggauugaanauccccgnuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((.........))))....(((((..]....)))))))))))).... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with Api137 antimicrobial peptide, mRNA, A-site release factor 1, and deacylated P-site and E-site tRNAphe at 2.70A resolution; P-site and E-site Deacylated tRNAphe 9d7t 2y 74 2.7 RF00005 39415050,39415050 0030533 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[..)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with Api137 antimicrobial peptide, mRNA, A-site release factor 1, and deacylated P-site and E-site tRNAphe at 2.70A resolution; P-site and E-site Deacylated tRNAphe 9d89 D 2728 1.95 RF02540,RF02541,RF02543,RF00002 39414793 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacagcugugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaaaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagcgucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcgcguuguuggguaggggagcguucuguaagccugugaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcggcgcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauauguucuaacguuggcccgugauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacuccuugagaguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<..>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<......>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<..>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<..>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.......<<<<<..<<<.>>>...>>>>>.......>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<..>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((())))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((......)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{........)))..))))).))...........]]].)...))))))))))...)))))))((((((((()))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((....(((((((((((.((.....))))))))))..)))...[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..(((.)))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((())))))...(((.(.((((.....)))).))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). E. coli 50S ribosomal subunit in complex with PrAMP rumicidin-2 (focused refinement); 23S rRNA 9d89 E 119 1.95 RF00001 39414793 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>> ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))) E. coli 50S ribosomal subunit in complex with PrAMP rumicidin-2 (focused refinement); 5S rRNA 9dfc 1A 2871 2.5 RF02540,RF02541,RF02543,RF00002 39372947 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<....<<<<........>>>..>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..<<.........>>...>>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<.......<<<<.<<<..>>>.>>>>....>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<...>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((...((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((....(((..........)..))...)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((..((.........))...))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((.(((((((((.(.........(((((..(((......((((((((....))))))))...)))............)))))).))))))))).))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..(((...)))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with lasso peptide lariocidin, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.50A resolution; 23S Ribosomal RNA 9dfc 1B 120 2.5 RF00001 39372947 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga .<<<<<<<<<<....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>. (((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).))))))))))) Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with lasso peptide lariocidin, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.50A resolution; 5S Ribosomal RNA 9dfc 1a 1500 2.5 RF00177,RF01959,RF02542,RF01960 39372947 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>.<..<<......>>.>..>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((((((....))))))).)))))......(((......((((((((..((...(((((((.(((((....((((.(....).)))).....)))))....((((..((((....))))..))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((.(((....))).)))....(((....)))....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with lasso peptide lariocidin, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.50A resolution; 16S Ribosomal RNA 9dfc 1v 13 2.5 39372947 10665 aaaaauguucuaa ............. ............. Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with lasso peptide lariocidin, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.50A resolution; MET-PHE-mRNA 9dfc 1w 75 2.5 RF00005 39372947 0030533 562 gcccgganagcucagugguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcaccn <<<<<<<..<<<<.......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((....[..)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with lasso peptide lariocidin, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.50A resolution; A-site Aminoacylated Phe-tRNAphe 9dfc 1x 77 2.5 RF00005 URS000041AF00_562 39372947 0030533 0006412 562 cgcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaaccn .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with lasso peptide lariocidin, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.50A resolution; P-site Aminoacylated fMet-tRNAmet 9dfc 1y 74 2.5 RF00005 39372947 0030533 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((......)))).((((.........)))).....(((((.......)))))))))))).... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with lasso peptide lariocidin, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.50A resolution; E-site Deacylated tRNAphe 9dfc 2A 2800 2.5 RF02540,RF02541,RF02543,RF00002 39372947 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<....<<............>.>....>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<..>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((...((((((((.....))))))))....{.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).))))....(((((((((.[.....)))))))))....}.(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((()))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...((((((((....(((..........)).)....))))))))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((.().)))))))).))..........]]].)....))))))))))...)))))))(((((((..)))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((.((((((((.(.........(((((..(((......((((((((....))))))))...)))............)))))).)))))))).)))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....))))))).((...)).....(((((((((.......)))))....((((((((.(((....(((((....)))))...)))..))))).)))...))))....))) Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with lasso peptide lariocidin, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.50A resolution; 23S Ribosomal RNA 9dfc 2B 120 2.5 RF00001 39372947 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.....<.<<<<<<<<....>>>>>>>>...>...>>>.>>>>>>>>>>> .((((((((((....((((((.(....(((((((...(.....)...))))..)))...).)))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with lasso peptide lariocidin, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.50A resolution; 5S Ribosomal RNA 9dfc 2a 1503 2.5 RF00177,RF01959,RF02542,RF01960 39372947 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggau .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<......>>....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((.(....).)))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...((((((......))))))....(.(....).)....)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.(.((....)).)).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with lasso peptide lariocidin, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.50A resolution; 16S Ribosomal RNA 9dfc 2v 13 2.5 39372947 10665 aaaaauguucuaa ............. ............. Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with lasso peptide lariocidin, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.50A resolution; MET-PHE-mRNA 9dfc 2w 72 2.5 RF00005 39372947 0030533 562 cccgganagcucagggagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcaccn <<<<<<..<<<<.....>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((...[.)))).((((.........)))).....(((((..]....)))))))))))..... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with lasso peptide lariocidin, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.50A resolution; A-site Aminoacylated Phe-tRNAphe 9dfc 2x 77 2.5 RF00005 URS000041AF00_562 39372947 0030533 0006412 562 cgcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaaccn .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with lasso peptide lariocidin, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.50A resolution; P-site Aminoacylated fMet-tRNAmet 9dfc 2y 73 2.5 RF00005 39372947 0030533 562 gcccgganagcucagggagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<.....>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[.)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with lasso peptide lariocidin, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.50A resolution; E-site Deacylated tRNAphe 9dfd 1A 2871 2.6 RF02540,RF02541,RF02543,RF00002 39372947 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<....<<...<<<<<<<<.....<<<........>>>......>>>>>>>>..>>.....>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..<<.........>>...>>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<...>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((..(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...((((((((.(..(((..........)..)))..))))))))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((..((.........))...))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.((((((.((.((((((.(......[..(((((..(((......((((((((....))))))))...)))..........].)))))).)))))).)).))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..(((...)))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with lasso peptide lariocidin B, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.60A resolution; 23S Ribosomal RNA 9dfd 1B 120 2.6 RF00001 39372947 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> (((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).))))))))))) Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with lasso peptide lariocidin B, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.60A resolution; 5S Ribosomal RNA 9dfd 1a 1500 2.6 RF00177,RF01959,RF02542,RF01960 39372947 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>.<.<<<<....>>>>>..>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.(((((((....))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((.(((....))).)))...((((....))))...)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with lasso peptide lariocidin B, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.60A resolution; 16S Ribosomal RNA 9dfd 1v 13 2.6 39372947 10665 aaaaauguucuaa ............. ............. Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with lasso peptide lariocidin B, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.60A resolution; MET-PHE-mRNA 9dfd 1w 75 2.6 RF00005 39372947 0030533 562 gcccgganagcucagugguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcaccn <<<<<<<..<<<<.......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((....[..)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with lasso peptide lariocidin B, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.60A resolution; A-site Aminoacylated Phe-tRNAphe 9dfd 1x 77 2.6 RF00005 URS000041AF00_562 39372947 0030533 0006412 562 cgcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaaccn .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with lasso peptide lariocidin B, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.60A resolution; P-site Aminoacylated fMet-tRNAmet 9dfd 1y 74 2.6 RF00005 39372947 0030533 562 gcccgganagcucaggguagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<......>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((......)))).((((.........)))).....(((((.......)))))))))))).... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with lasso peptide lariocidin B, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.60A resolution; E-site Deacylated tRNAphe 9dfd 2A 2800 2.6 RF02540,RF02541,RF02543,RF00002 39372947 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<............>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<..>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((.....((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..)).)))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((()))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((....(((..........)).)....)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((((((()))))))))).))..........]]].)....))))))))))...)))))))(((((((())))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((.((((((((.(.........(((((..(((......((((((((....))))))))...)))............)))))).)))))))).)))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....))))))).(((.))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with lasso peptide lariocidin B, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.60A resolution; 23S Ribosomal RNA 9dfd 2B 120 2.6 RF00001 39372947 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with lasso peptide lariocidin B, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.60A resolution; 5S Ribosomal RNA 9dfd 2a 1503 2.6 RF00177,RF01959,RF02542,RF01960 39372947 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggau .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<......>>....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((.(....).)))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(((((((....))))))).(..(((....)))..).)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))..[)).)))))))).(...(((((((.....(((..(((.(.((....)).)).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with lasso peptide lariocidin B, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.60A resolution; 16S Ribosomal RNA 9dfd 2v 13 2.6 39372947 10665 aaaaauguucuaa ............. ............. Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with lasso peptide lariocidin B, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.60A resolution; MET-PHE-mRNA 9dfd 2w 72 2.6 RF00005 39372947 0030533 562 cccgganagcucagggagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcaccn <<<<<<..<<<<.....>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((...[.)))).((((.........)))).....(((((..]....)))))))))))..... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with lasso peptide lariocidin B, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.60A resolution; A-site Aminoacylated Phe-tRNAphe 9dfd 2x 77 2.6 RF00005 URS000041AF00_562 39372947 0030533 0006412 562 cgcggggnggagcagccugguagcucgucgggnucauaacccgaaggucgucggnucaaauccggcccccgcaaccn .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with lasso peptide lariocidin B, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.60A resolution; P-site Aminoacylated fMet-tRNAmet 9dfd 2y 73 2.6 RF00005 39372947 0030533 562 gcccgganagcucagggagagcaggggauugaanauccccgunuccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<.....>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((...[.)))).((((.........)))).....(((((..]....)))))))))))).... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with lasso peptide lariocidin B, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.60A resolution; E-site Deacylated tRNAphe 9dfe 1A 2872 2.6 RF02540,RF02541,RF02543,RF00002 39372947 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcgcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccgagggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcagcggccgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccacggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<..>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<..>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>...<<<..>>>...>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<...<<.........>>...>>>.........<<......>>...>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<..>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<<<<<<...........<<<<<..<<.......<<<<<<<......>>>>>>>....>>............>>>>>..>>>>>>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<.<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>..>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<.>>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).(((((()))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((..(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((..))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))...(((())))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...((((((((.(.((((((......)))).)))..))))))))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.....{.(((((.(((....(.........)....))).....(...((......)).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))((((((((.....))))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...(((()))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((.((((((.([.....{..(((((..((.......(.((((((...])))))).)....))..........}.)))))).)))))).)))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))..((((.))))....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))....))) Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with lasso peptide lariocidin and protein Y at 2.60A resolution; 23S Ribosomal RNA 9dfe 1B 120 2.6 RF00001 39372947 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with lasso peptide lariocidin and protein Y at 2.60A resolution; 5S Ribosomal RNA 9dfe 1a 1500 2.6 RF00177,RF01959,RF02542,RF01960 39372947 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcggguccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<.<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>...<<........>>..>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>..>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((..)))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((...(((((((....)))))))...((((....))))...)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...))))))).....(((((....)))))........)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with lasso peptide lariocidin and protein Y at 2.60A resolution; 16S Ribosomal RNA 9dfe 2A 2867 2.6 RF02540,RF02541,RF02543,RF00002 39372947 0003735 0005840 300852 agaugguaagggcccacgguggaugccucggcacccgagccgaugaaggacguggcuaccugcgauaagccagggggagccgguagcgggcguggaucccuggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgcugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccuaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaauccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagcagucacggccccggggguuguggcgugccuauugaagcaugagccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaaccgaguccgaacagggcgcaagcgcgcaaaguccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaagcuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagcacugauagggcuagggggcccaccagccuaccaaacccugucaaacuccgaagggucccagguggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggagguggcuuagaagcagccauccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagcugcgggucuggggccccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaacaagcucugcgugguggggaagcccgcgggugacaaccccccgaagccagggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggugcucccuggggugaugagccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcggccguaacnauaangguccuaagguagcgaaanucnuugucggguaaguuccgacnugcacgaaaagcguaacgaccggagcgcugucucggcgagggacccggugaaauugaacuggccgugaagaugcggccuacccguggcaggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgccugcguaggauaggugggagccugugaacccccgccuccgggugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcaguuugacugnggcggucgccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccgagcguccacagcggcggggagguuuggcaccucgnugucggcucgucgcauccuggggcugaagaaggucccaaggguugggcnguucgcccauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccggaagggacgcaccucugguuucccagcugucccuccaggggcauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccggcagccgguaaggacccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<.>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>.>>...............<<....>>....>>.........<<<<....>>>>..................>>>>>>>>>>>.......<<<<<<<<<<<.>>>>>>>>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>....<<..>>...>>>>>>>>>>>>>..<<.<...<<<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>>..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<<<<<........<<<<<.<<<..................>>>......................>>>>>....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>>>>>>><<<<<<<..>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><...<<<<..>>>>.....>>>>>>...>>>..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<..<<...........>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<..<<<.......<<<<<<......>>>>>>....>>>............>>>>>..>>>>.>>>>>>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<.<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>..>....<<<<<<<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>.<<<.>>>.....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>> (((......((((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))((((((((....)))))))).((((((.)))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((([...((((((((.....))))))))....(.(((((((((....(((...(((((.((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))..)))))..))))))))).)))]....(((((((((.[.....)))))))))....).(((((].[[[[)))))..)))......)).)))))).))...............((....))....))......(..((((....))))............)).....)))))))))).....(.(((((((((((.))))))))))).[.(.(........).).((((((....(((((((((((((..(((...(((.....)))...)))...((....))..((((.....))))....((..))...)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((..((((.......<)))).)))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))(((((((((.([..(((((((((...(((...(((.((((.(.((((((......)))).)))..)))).)))..)).)...)))))))))..).]))))))).))..(((((((.((......)).))))))).....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((((((((((.......(((((.((.....(.......)......)).....(...(........).).)))))...)))))))))).))..........]]].)....))))))))))...)))))))(((((((())))))))....))))))(.(((((...(((......(((((.(((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[((((.((...(((...(((....)))...)))...))...(((((........)))))]](((((((((((((...((((....(((((.(((..(((((.((((.(((..{{..).))))))(((...((((((((((((((((.((.....))))))))).....)))))))))..)))(...((((..)))).....))))))...)))..)))))(..).....))))...))...))))))))))))))).))).....((......)).)))).(((((....)))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((.....))))))))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((...((...(((((....)))))...))...))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((..(......((((.((((((..(((((.(((.(((((.(((((((((.(.((((.(......[..(((((..(((.......((((.((....)).))))....)))..........].)))))).)))).).)))))))))...(((((....)))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..(((...{..)))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(.(((((....))).)).)..>.)...)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((.}}.))))))...)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))((((.))).....(((((((((.......)))))....((((((((..((....(((((....)))))...))...))))).)))...))))...)))) Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with lasso peptide lariocidin and protein Y at 2.60A resolution; 23S Ribosomal RNA 9dfe 2B 120 2.6 RF00001 39372947 0003735 0005840 300852 ucccccgugcccauagcggcguggaaccacccguucccauuccgaacacggaagugaaacgcgccagcgccgaugguacugggcgggcgaccgccugggagaguaggucggugcggggga <<<<<<<<<<<....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>><<<.......<<<<<<<<....>>>>>>>>.......>>>.>>>>>>>>>>> .((((((((((....((((((((....(((((((...(.....)...))))..)))...)))))).))(((.......((((((((....)))))))).......))).)))))))))). Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with lasso peptide lariocidin and protein Y at 2.60A resolution; 5S Ribosomal RNA 9dfe 2a 1504 2.6 RF00177,RF01959,RF02542,RF01960 39372947 0003735 0005840 300852 uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagacaugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaacucgggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaauggcccaccaaggcgacgacggguagccggucugagaggauggccggccacaggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgugccagcagccncgguaauacggagggcgcgagcguuacccggauucacugggcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgugggggagcgugggauacgcucaggcuagacggugggagagggugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaannaacgcgaagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggaggaaggaggggacgacgucuggucagcaugncccuuacggccugggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauacguucccgggccuuguacacacngncngunacgccaugggagcgggcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgugacuggggcgaagucgnaacaagguagcuguaccggnnggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>....<<<<<........<<<<.....>>>>..........>>>>>......<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<.<......<<........>>..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>.....<.....>.....>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>..>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<..........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... .....((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((((((((((..)))))))))).)))))......(((......((((((((..((...(((((((.(((((....((((((....)))))).....)))))....((((.(((((....))))).))))...((((...)))).)))))))..))))))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))....(((((...(....((((.....)))).....)....)))))......((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....((((((....((........)).......))))))....).......((....)).)))))))..))))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((...))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((...(((((((....))))))).(..(.(....).)..).)))))))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((..(((..(((.....))))))...)))))))..(..(((((....))))).....)..)))).....).).)))...)).)))))....)))))))).[)).)))))))).(...(((((((.....(((..(((.((((....))))).))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((......]...)))))))......))...)))))))))).))..(.(..((.(.((((..((..(((((((((((((...(.((((....(((....))).)))).)..)))))))))))))..))..))))..).))...)..)..(((((((((....)))))))))}.... Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with lasso peptide lariocidin and protein Y at 2.60A resolution; 16S Ribosomal RNA 9dll A 13 NA 9606 gacagcagcuguc ............. ............. NMR structures of small molecules bound to a model of an RNA CAG repeat expansion.; CAG 13-mer RNA (5'-R(*GP*AP*CP*AP*GP*CP*AP*GP*CP*UP*GP*UP*C)-3') 9dll B 13 NA 9606 gacagcagcuguc ............. ............. NMR structures of small molecules bound to a model of an RNA CAG repeat expansion.; CAG 13-mer RNA (5'-R(*GP*AP*CP*AP*GP*CP*AP*GP*CP*UP*GP*UP*C)-3') 9dtr 2 132 2.31 RF00004 38746449 0045131 0000348 0005686 4932 aaucucuuugccuuuuggcuuagaucaaguguaguaucuguucuuauuuuuuggcaccuggacgggaagagacuuuaaagugagacgucgcgacccucgcacuuggucgcuugauguuucucuucccguucg ...........................................................<<<<<<<<<<..<<<<..>>>><<<<<<<<<<<<<<.........>>>>>>..>>>>>>>>.>>>>>>>>>>. ...........................................................((((((((((.(.(((()))))(((((((((((.((.........)).)))..)))))))).)))))))))). Structure of the yeast post-catalytic P complex spliceosome at 2.3 Angstrom resolution; U2 snRNA 9dtr 5 173 2.31 RF00020 38746449 0000244,0000353 0005682,0046540 4932 agcagcuuuacagaucaauggcggaggaggucaacaucaagaacugugggccuuuuauugccuauagaacuuauaacgaacaugguucuugccuuuuaccagaaccauccggguguugucuccaugaaacagguaaagcuguccguuacugugggcuugccauuuuuuggaac .<<<<<<.<<<<<.....<<<<<<<<<<<<.<<<<<<<.....<<<<<<<<........>>>>>>>>..............<<<<<<<<...........>>>>>>>>...>>>>>>>>>>>>......<<<......>>>>>>>>>>>>>>>>>>>.>>............. .(((((((.((((.....((((((((((((.(((((((.....((((((((........)))))))).........((...((((((((.(.......).)))))))).))))))))))))))......(((......))))))))))))))))))).))............. Structure of the yeast post-catalytic P complex spliceosome at 2.3 Angstrom resolution; U5 snRNA 9dtr 6 102 2.31 RF00026 38746449 0030621 0000244,0000353 0005688,0046540 4932 guucgcgaaguaacccuucguggacauuuggucaauuugaaacaauacagagaugaucagcaguuccccugcauaaggaugaaccguuuuacaaagagauuu <<<<<<<<<<.....>>>>>>>>>>.....................................<<<..<<<.....>>>...>>>.................. ((((((((((.....)))))))))).....................................(((.((((.....)))..)))).................. Structure of the yeast post-catalytic P complex spliceosome at 2.3 Angstrom resolution; U6 snRNA 9dtr E 33 2.31 38746449 4932 agugaucuagaaagagauccaccuaucauguug ................................. ................................. Structure of the yeast post-catalytic P complex spliceosome at 2.3 Angstrom resolution; UBC4 mRNA spliced exons 9dtr I 48 2.31 38746449 4932 guaugucuaaaguuaugcucuuauuuacuaacaaaaucauugaacuag ................................................ ................................................ Structure of the yeast post-catalytic P complex spliceosome at 2.3 Angstrom resolution; UBC4 lariat-intron 9e6q 1 2842 1.95 RF02540,RF02541,RF02543,RF00002 0003735 0005840 410359 uaggcaaagccgcccgguggauggcucggcucgggcgncgaagaagggcguggcaagcugcgauaagcccgggguagcngcaggcaggcuuagaacccgggauccccgaauggggcuuccugccggggccgaauaggccccggcgccccguaaggggcgggaacgcggggaaaggaaacaucuuaguacccgcaggaagggaagccaacagggacccccugaguaggggcgaccgaaagggggauagcccaaaccaaauccucgcgggacaaccguggggagauguggggcuugggcccgggcaaccgccggcgggcgguagccgaagugggcuggaaugccccgccguagagggugauagccccguaggcgaaaccgcccguggcggagucccggggucccggaguaccucggcuuaguuuugccgggggaacgcgccggccacuggccggcaaggcuaagcacgucccgaguccgauagcgcacuaguanngugagggaaagcugaaaagaaccccggaaggggggugaaaagagccugaaaccgggcggcuacaguggggcaggcccgaaaggaugcccccucccgaaggaaaccccggugacgggggaguacgagggaggggguccagggucugcccuuacgucuagaaacacgggccggggaguucanggccguggcgagccuaagggguucaaccccggaggcguagggaaaccgacagcccgcagcggggcaacccgcgaggggcggggucuuaaagggcccguagucacggccgugagaccagaaaccgggcgaucuagcccugggcagggugaagcggggcgaaagccccguggaggcccgaagggguucugaugugcaaaunguncccaugaccuggggcuaggggcaaaanaccaancaagcccggugauagcugguuccccccgaagcgggucucagcccggccuccccggaggcggccggcgggguagaguacugaucggggccccggucaaacuccgaaccugccagcgccguagaaggggggaggcgggggcggugggguaagccuccgcuccgagacgggaacaaccgagaccgggguuaaggcccccaagugcgggcuuagugucaaucuaaaagggcgucccccgcccaagacagccgaggcggggggccccgaagauguacagggacuaagcccgccgccgagaccccggcccgcgggccguuggcccgcgugggguaggggggcgcggccguggggcagaagccgggccgugagguccgguggacccgcggccgacgaagaucccggcgguaguagcagcgaagaggggugagaagccccuccgccggaaaggaccaggguuuccuggcaacuucaauaggccaggaguuagccgguccuaaggcggggccuaauaggcacccgccgaaagggaaacggguuaauauucccgugccgcggggguagguucugcggcaacgcaggccccguccccgacgccucgggauagggcgggcgggacugccgucccgcuuaaccgucgaaggccggggagugccguaauggcgagaaccggccgaaggcgggaauagccggggguuuccccgguccgcccgacuccuggggcccgugaaaaggggacggggaacgagcccccgcgcccguaccgagaaccgacgcaggugcuccugggugagaagcccaaggcggcucgggugaccccgggccagggaacunggcaaauuggccccguaacuucgggagaaggggugccugcggucuugggguauacccccgggaccgcaggucgcaguggcaagggggaccugacuguuuaacaaaaacauagguccccgcgagcccguaangnuguguacnggggcugaauccungccanuggcgguacguganccccggguacaaccgggcgangcgcnnnugaaggccgggggcccucuuaagguagcnaanugccuunccggnuaagunccggcgugcangaauggaucaacgannuccccacugunncggcccggggcccggcgaacccaccuncaggugcacagnccugggacccccgacggggcnagaagucccuauggagcuucacagcagccugucguugcggguccgcuuacccgccgcaaggcggggacagcggcaggcgggcuguucggcugnggcngcacaccccugaaaagauaucnggggugcccaaagcucggcncaggcgggucagaaauccgccguagaguguaagggcaaaagccgggcugacugggcccuugaacgcaaggggcccaggcgggaaaccggggccuagagaacgcucgugcccccaccagugggggccggnnaugacagaaaaguuacncuaggaauaaccggcucgncgcgggugagaguccccaucgaccccncgguuunguacccagacgucgnnucuncccauccuggcggugcagcagccgccaaggguggggcnncccgcccauuaaaggggaacgugngaugggnucagancgncgcgagacaggunggucucuaccugucgggggcgcuggccgccugaggggaaggugcccucaguacgagaggaacggggcgccgcggccucuaguguaccgguuguccggcagggcacugccgggcagccacgccguggggganaaccgcugaaagcaucuaagcgggaagcccucnncgagacgaggcggccguugcccugggggcaaccccggggcacgagggcuccnguagaagacgggguugaugggggggcgguguaacccccgaggguuucccgaggggagagccggccccucccaaucgcccgagcgunc ..<....<<<<<<<<<<<.....((..((<<<<<<((<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<....>>><<<<<<<<<.....>>>>>>>>><<<<<....>>>>>>>...<<<<<<....<<<....>>>.....>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<..<<<<<<<<<.....>>>>>>>>>....>>>.....<<<<<<<<<...<<<<<.<<<<<<<<<.<<<.....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>...>>>>>>..>>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......)).>>>>>>.))...............<<....>>....)).........<<<<....>>>>.................>>>>>>>>>>>.....<<<<<<<<<<<....<<..<<<<<<<<<<...<....<<<<<....>>>>>.....>..>>>>>>>>>>>>.>>>>>>>>>>>..<<<........>>>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<...<<<<<....>>>>>...>>>>.<<<<<<....>>>>>>...>>>>>>>>>>>>>..<<<<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<.....<<........>>...>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>>>>..<<<<<<....<<<<<....>>>>>.<<<<<<<...<<<.<<.<<<<<<...<<<...<<<<<<<<..>>>>>>>>..>>.>...>>>>>>.>>>>>......>>>>>>.>...<<<<<<<.<<<.....>>>>>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<............>>>>>>>>>>>>>...........)))>>...>>>>>>.>>>...>>>>>>><<<<<<<<<<...>>>>>>>>.>>....>>>>>><.<<<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<......<<<<<<.......>>>>>><<<<.....<<<...<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<<<<.....>>>.>>>>>>....>>>..<<<<<........>>>>>))<<<<<<<<........<<<....>>>...<<<<<<<<<<...<<<<<<<<<..<<<<<<<<<<<<<.(((>>>>>>><...<<<<<...<<<<<<.....<<<<...>>>>.....>>>>>>...>>>>>....><<<<<<<<..>>>>>>>>>>>>>>...>>>>>>>>>.........>>>>>>>>>>......>>>>>>>>.>>>..>>.....<<......>>...>>><<<<<.....>>>>>.>>>>...<<<<<...<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<<<<<<<<<<<.....>>>>>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<....>>>>......>>>>>>>..<<<<.<<<..<<<<<<<..<<<....<<<<<......>>>>>....>>>>>>>>..>>>>><<<<..>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>...>>.>>>>>>>.....>>.>>>>>>>>>>>>>>>....>>....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<<.<<<<..>>>>...<<<<<<....>>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>)))]......<<<<<...<<<<.>>>>>>>>>>.>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>..<<<<.....>>>>......>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<.....<<...<<<<<<<<<<))).>>>>>..>>>>>...>>...>>>>>.<<<<.<..<<<<<...........>>>>>...>>>>>>>>>.......>>>>>>>..<<<<<<<<<<....>>>>>>>>>>...<<<<<<<<<.......>>>>>....<<<<<<<<<<<<.....<<<<..<<.....>>..>>>>...>>>>.>>>>>.>>>...>>>>...>.... ..(.....(((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))(((((((((.....)))))))))(((((....)))))))...((((((....((...[..)).....))))).)...(.....((....))...(((((.....((.]...))....)))))...((((...((..((((((((((.....)))))))))....))).....((((((((((.[(((((.(((((((((.(((...({((((......)))))[[(...).(((....}]])))...)))...)))))))))))))).)]))))))..))).)....(((((((........)))))))......(((((.[[[[[[)))))..)))....).)).)))))).))...............((....))....))......(..((((....))))...........)).....)))))))))......(((((((((((....((..((((((((((...(....(((((....))))).....)..)))))))))))).)))))))))))A.(((........))).((((((....(((((((((((((..(((...((((.....))))...)))...((....))..(.((((...(((((....)))))...)))))((((((....))))))...)))))))))))))..((((...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((...(.((.......B)))..)))..).))))))))).(.((.......))...)..))))))......))))..((((((....(((((....))))).(((((((...(((.((.((((((...(((...((((((((()))))))))..)).)...)))))).)))))......)))))).)...(((((((.(((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((..........(((.((((((((((.....<.()...)))))))))))))...........]]]))...))))))))))...)))))))((((((((((...)))))))).))....))))))(.((((((((((......((((((((....))))))))...))))))))))..).....))))))((.....((......((((((.......))))))((((.[...(((...((..(((((((...((.....)).))))))....[[(((.((...(((((((((.....))).))))))....))...(((((........)))))]]((((((((..(.....(((....)))...((((((((((...(((((((((..((((((((((((..{{{.))))))(...(((((...((((((.....(((.....))).....))))))...)))))....)((((((((..))))))))))))))..])))))))))(...)....))))))))))..)...)))))))).))).))).....((......))...))).((((.....))))..))))...(((((...((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((((((.....))))))))))))))))(...).......(((((((((.].((.........))...(((((((....((((....))))......))))))).}.(((.(((..(((((((..((.....(((((......))))).....)))))))..)))))(.((())).)........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))))))))))....))[[..(((((.....a]])))))..((((((((.(((.((......((((.((((((..(((((.(((((((((.((((()))))...((((((....))))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(.((((.]]]]]]))))))))))....).....))))..)))))).......(.(....((((((...((.......))...)))))).....)..)........((((.((((((..(((((((((......))))))..)))..((((.....))))......)))))..)...))).).....(((((((....))).))))..b.))..)))))))))))[...(((((((...((((..((((((((.....(....)....))))))))(((((...(.((...((((((((((}}}.)))))..))))).{.)).).))))).((((....((((.....>.......))))....))))))))..]....)))))))..((((((((((....))))))))))(..((((.((((.......)))).....((((((((((((.....((((..((.....))..))))...))))}))))).)))...))))..)).... Cryo-EM structure of the Pyrobaculum calidifontis 50S ribosomal subunit in complex with Dri; 23S rRNA 9e6q 2 129 1.95 RF00001 0003735 0005840 410359 gccccuaacccggccauaggcgccggugcuacacccggucucaucagaacccggaaguuaaggccggcgccgcgcucgggaguacugggcuccgcgagggcccgggaaaccggcgugcugggagggggc <<<<<<..<<<<<<....<<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>>>><<<<.<<<.....<<<<<<.<<....>>>>>>>>....>>>>>>>>>>>>>.>>>>>> ((((((..((((((....(((((((((.....((((((...(....)...))))..))....)))))))))((((.(((.....((((((.((....))))))))....))))))))))))).)))))) Cryo-EM structure of the Pyrobaculum calidifontis 50S ribosomal subunit in complex with Dri; 5S rRNA 9e71 2 129 2.36 RF00001 0003735 0005840 410359 gccccuaacccggccauaggcgccggugcuacacccggucucaucagaacccggaaguuaaggccggcgccgcgcucgggaguacugggcuccgcgagggcccgggaaaccggcgugcugggagggggc <<<<<<..<<<<<<....<<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>>>><<<<.<<<.....<<<<<<.<<....>>>>>>>>....>>>>>>>>>>>>>.>>>>>> ((((((..((((((....(((((((((.....((((((...(....)...))))..))....)))))))))((((.(((.....((((((.((....))))))))....))))))))))))).)))))) Cryo-EM structure of the Pyrobaculum calidifontis 70S ribosome; 5S rRNA 9e71 1 2849 2.36 RF02540,RF02541,RF02543,RF00002 0003735 0005840 410359 uaggcaaagccgcccgguggauggcucggcucgggcgncgaagaagggcguggcaagcugcgauaagcccgggguagcngcaggcaggcuuagaacccgggauccccgaauggggcuuccugccggggccgaauaggccccggcgccccguaaggggcgggaacgcggggaaaggaaacaucuuaguacccgcaggaagggaagccaacagggacccccugaguaggggcgaccgaaagggggauagcccaaaccaaauccucgcgggacaaccguggggagauguggggcuugggcccgggcaaccgccggcgggcgguagccgaagugggcuggaaugccccgccguagagggugauagccccguaggcgaaaccgcccguggcggagucccggggucccggaguaccucggcuuaguuuugccgggggaacgcgccggccacuggccggcaaggcuaagcacgucccgaguccgauagcgcacuaguanngugagggaaagcugaaaagaaccccggaaggggggugaaaagagccugaaaccgggcggcuacaguggggcaggcccgaaaggaugcccccucccgaaggaaaccccggugacgggggaguacgagggaggggguccagggucugcccuuacgucuagaaacacgggccggggaguucanggccguggcgagccuaagggguucaaccccggaggcguagggaaaccgacagcccgcagcggggcaacccgcgaggggcggggucuuaaagggcccguagucacggccgugagaccagaaaccgggcgaucuagcccugggcagggugaagcggggcgaaagccccguggaggcccgaagggguucugaugugcaaaunguncccaugaccuggggcuaggggcaaaanaccaancaagcccggugauagcugguuccccccgaagcgggucucagcccggccuccccggaggcggccggcgggguagaguacugaucggggccccggucaaacuccgaaccugccagcgccguagaaggggggaggcgggggcggugggguaagccuccgcuccgagacgggaacaaccgagaccgggguuaaggcccccaagugcgggcuuagugucaaucuaaaagggcgucccccgcccaagacagccgaggcggggggccccgaagauguacagggacuaagcccgccgccgagaccccggcccgcgggccguuggcccgcgugggguaggggggcgcggccguggggcagaagccgggccgugagguccgguggacccgcggccgacgaagaucccggcgguaguagcagcgaagaggggugagaagccccuccgccggaaaggaccaggguuuccuggcaacuucaauaggccaggaguuagccgguccuaaggcggggccuaauaggcacccgccgaaagggaaacggguuaauauucccgugccgcggggguagguucugcggcaacgcaggccccguccccgacgccucgggauagggcgggcgggacugccgucccgcuuaaccgucgaaggccggggagugccguaauggcgagaaccggccgaaggcgggaauagccggggguuuccccgguccgcccgacuccuggggcccgugaaaaggggacggggaacgagcccccgcgcccguaccgagaaccgacgcaggugcuccugggugagaagcccaaggcggcucgggugaccccgggccagggaacunggcaaauuggccccguaacuucgggagaaggggugccugcggucuugggguauacccccgggaccgcaggucgcaguggcaagggggaccugacuguuuaacaaaaacauagguccccgcgagcccguaangnuguguacnggggcugaauccungccanuggcgguacguganccccggguacaaccgggcgangcgcnnnugaaggccggggguaacugacccucuuaagguagcnaanugccuunccggnuaagunccggcgugcangaauggaucaacgannuccccacugunncggcccggggcccggcgaacccaccuncaggugcacagnccugggacccccgacggggcnagaagucccuauggagcuucacagcagccugucguugcggguccgcuuacccgccgcaaggcggggacagcggcaggcgggcuguucggcugnggcngcacaccccugaaaagauaucnggggugcccaaagcucggcncaggcgggucagaaauccgccguagaguguaagggcaaaagccgggcugacugggcccuugaacgcaaggggcccaggcgggaaaccggggccuagagaacgcucgugcccccaccagugggggccggnnaugacagaaaaguuacncuaggaauaaccggcucgncgcgggugagaguccccaucgaccccncgguuunguacccagacgucgnnucuncccauccuggcggugcagcagccgccaaggguggggcnncccgcccauuaaaggggaacgugngaugggnucagancgncgcgagacaggunggucucuaccugucgggggcgcuggccgccugaggggaaggugcccucaguacgagaggaacggggcgccgcggccucuaguguaccgguuguccggcagggcacugccgggcagccacgccguggggganaaccgcugaaagcaucuaagcgggaagcccucnncgagacgaggcggccguugcccugggggcaaccccggggcacgagggcuccnguagaagacgggguugaugggggggcgguguaacccccgaggguuucccgaggggagagccggccccucccaaucgcccgagcgunc ..<....<<<<<<<<<<<.....((..((<<<<<<((<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<....>>><<<<<<<<<.....>>>>>>>>><<<<<....>>>>>>>...<<<<<<....<<<....>>>.....>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<..<<<<<<<<<.....>>>>>>>>>....>>>.....<<<<<<<<<...<<<<<.<<<<<<<<<.<<<.....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>...>>>>>>..>>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......)).>>>>>>.))...............<<....>>....)).........<<<<....>>>>.................>>>>>>>>>>>.....<<<<<<<<<<<....<<..<<<<<<<<<<...<....<<<<<....>>>>>.....>..>>>>>>>>>>>>.>>>>>>>>>>>..<<<........>>>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<...<<<<<....>>>>>...>>>>.<<<<<<....>>>>>>...>>>>>>>>>>>>>..<<<<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<<....<<........>>..>>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>>>>..<<<<<<....<<<<<....>>>>>.<<<<<<<...<<<.<<.<<<<<<...<<<...<<<<<<<<..>>>>>>>>..>>.>...>>>>>>.>>>>>......>>>>>>.>...<<<<<<<.<<<.....>>>>>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<............>>>>>>>>>>>>>...........)))>>...>>>>>>.>>>...>>>>>>><<<<<<<<<<...>>>>>>>>.>>....>>>>>><.<<<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<......<<<<<<.......>>>>>><<<<.....<<<...<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<<<<.....>>>.>>>>>>....>>>..<<<<<........>>>>>))<<<<<<<<........<<<....>>>...<<<<<<<<<<...<<<<<<<<<..<<<<<<<<<<<<..(((.>>>>>><...<<<<<...<<<<<<.....<<<<...>>>>.....>>>>>>...>>>>>....><<<<<<<<..>>>>>>>>>>>>>>...>>>>>>>>>.........>>>>>>>>>>......>>>>>>>>.>>>..>>.....<<......>>...>>><<<<<.....>>>>>.>>>>...<<<<<...<<<<<<<<.<<...............<<<<<....<....>.....>>>>><<<<<<<<<<<<<<<<.....>>>>>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<....>>>>......>>>>>>>..<<<<.<<<..<<<<<<<..<<<....<<<<<......>>>>>....>>>>>>>>..>>>>><<<<<<.....>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>...>>.>>>>>>>.....>>.>>>>>>>>>>>>>>>....>>....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<<.<<<<..>>>>...<<<<<<....>>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>)))]......<<<<<...<<<<.>>>>>>>>>>.>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>..<<<<.....>>>>......>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<.....<<...<<<<<<<<<<))).>>>>>..>>>>>...>>...>>>>>.<<<<.<..<<<<<...........>>>>>...>>>>>>>>>.......>>>>>>>..<<<<<<<<<<....>>>>>>>>>>...<<<<<<<<<.......>>>>>....<<<<<<<<<<<<.....<<<<..<<.....>>..>>>>...>>>>.>>>>>.>>>...>>>>...>.... ..(.....(((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))(((((((((.....)))))))))(((((....)))))))...((((((....((...[..)).....))))).)...(.....((....))...(((((.....((.]...))....)))))...((((...((..((((((((((.....)))))))))....))).....((((((((((.[(((((.(((((((((.(((...({((((......)))))[[(...).(((....}]])))...)))...)))))))))))))).)]))))))..))).)....(((((((........)))))))......(((((.[[[[[[)))))..)))....).)).)))))).))...............((....))....))......(..((((....))))...........)).....)))))))))......(((((((((((....((..((((((((((...(....(((((....))))).....)..)))))))))))).)))))))))))A.(((........))).((((((....(((((((((((((..(((...((((.....))))...)))...((....))..(.((((...(((((....)))))...)))))((((((....))))))...)))))))))))))..((((...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((...(.((.......B)))..)))..).))))))))).(.((.......))...)..))))))......))))..((((((....(((((....))))).(((((((...(((.((.((((((...(((...(((.((((())))).)))..)).)...)))))).)))))......)))))).)...(((((((.(((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((..........(((.((((((((((.....<......)))))))))))))...........]]]))...))))))))))...)))))))((((((((((...)))))))).))....))))))(.((((((((((......((((((((....))))))))...))))))))))..).....))))))((.....((......((((((.......))))))((((.[...(((...((..(((((((...((.....)).))))))....[[(((.((...(((((((((.....))).))))))....))...(((((........)))))]]((((((((..(.....(((....)))...((((((((((...(((((((((..((((((((((((..{{{.))))))(...(((((...((((((.....(((.....))).....))))))...)))))....)(((((((....)))))))))))))..])))))))))(...)....))))))))))..)...)))))))).))).))).....((......))...))).((((.....))))..))))...(((((...((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((((((.....))))))))))))))))(...).......(((((((((.].((.........))...(((((((....((((....))))......))))))).}.(((.(((..(((((((..((.....(((((......))))).....)))))))..)))))(.((((.....)))).)........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))))))))))....))[[..(((((.....a]])))))..((((((((.(((.((......((((.((((((..(((((.(((((((((.((((()))))...((((((....))))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(.((((.]]]]]]))))))))))....).....))))..)))))).......(.(....((((((...((.......))...)))))).....)..)........((((.((((((..(((((((((......))))))..)))..((((.....))))......)))))..)...))).).....(((((((....))).))))..b.))..)))))))))))[...(((((((...((((..((((((((.....(....)....))))))))(((((...(.((...((((((((((}}}.)))))..))))).{.)).).))))).((((....((((.....>.......))))....))))))))..]....)))))))..((((((((((....))))))))))(..((((.((((.......)))).....((((((((((((.....((((..((.....))..))))...))))}))))).)))...))))..)).... Cryo-EM structure of the Pyrobaculum calidifontis 70S ribosome; 23S rRNA 9e71 4 1430 2.36 RF01959,RF00177,RF02542,RF01960 0003735 0005840 410359 aaacngnuugauccngccngacccgaccgcuaucggggungggcuaagccaugcgagucgcgcgcccgggggcgcccgggagcggcgcacggcucaguaacacgugccuaaccuaaccucgggagggggacacccccgggaaacuggggucaaucccccauaggggaagggcgcuggaaggccccuuccccgaaagggcuggcggccgauccgccgccagucgcccgagggugggggcacggcccaucagguaguuggcggguuaaaggcccgccaagccgaagacggguaggggcggugagagccgcgagccccgagaugggcacugagacaagggcccaggcccuacggggugcagcaggcgcgaauacuccgcaaugcgggcaaccgcgacggggcuaccccgagugccgggcgaagagcccggcuuuugcccggucuaaaaagccgggagaauaagcnggngncaagucungugucagccgccgngguaaunccagcuccgcgngungungggguguuuacugggcuuaaagcgcccguagccggcccggcaagucgcuccuganauncccgggcucaacccgggggccgggggcgauacugccgggcuagggggcgggagaggccgccgguacuccggggguaggggcgaaauccguuaauccccggangaccaccaguggcgaaagcgggcggccagaacgcgcccgacggugaggggcgaaagccgggggagcaaaggggauuagauaccccuguagucccggccguaaacgaugcgggcuagcugucggucgggcuuagggcccggccgguggcgaagggaaaccguuaagcccgccgccuggggaguacggccgcaaggcugaaacunannggaauuggcgggggggcaccacaagngnugaagcuugcggcuuaauuggaaaaccucacccgggggaggugcauggccgucgucagcucgugnngugagguguncgguuaaguccggcnacgagcgagacccccgccccuaguugcuaccccucccuacggggaggggggcacacuagggggacugccggcguaagccggaggaaggagggggccacggcangucaguaugccccgaaacccnggggcugcacgcgagcuncaauggcnnngacagcgggauccgaccccgaaagggggaggcaaucccguaaaccccgccccaguagggaucgagggcugcaacucncccucgugaacguggaaucccuaguaacngcgugucaccaacgcgcggugaauacgucccugccccuugcacacaccgnccgucgcaccacccgagggagcccucugcgaggccccucgccgguggggggacgagcagggggcucccaaggggggugaagucguancaagguagcnguaggggnnccugcggcuggaucacc ...<<<<..[.((((.>>>>.<<<<<<<<<..<<<<<<.<<......<<<.<<<..<<<..<<.<<<<<<((((>>>>>>.>>>>>......<<........<<<<<<<..<<.<.<<<<<<<.<<<<<....<<<<<<....>>>>>>.....>>>>>...<<<<<<<<<.<<......>>>>>>>>>>>.....<<<<<<<<<<))..))>>>>>>>>>>.>>>>>>>.>>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>....>>>>.>>.<<<<<............>>>>>.<<<<<..>>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<<<<.....>>>>>>>.....<<<<<<.......>>>>>>.......<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<....<<<<<<<<.....>>>>>>>>..>>>>>>>>..>>>>>>>>>...<<<<<<.....<<<<<<<<<..<<<<<<<<<..<<<......>>>.....>>>>>>>>>..>>.......<<....>>.>>>>>>>....>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<<<.....>>>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<.<<<<<<..<<<<<<<<<<.................<<<<<.<<.<<<..<<<<<<<<.....<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>....<<<<<.<<<<<<...<<<.<<<<<<<<....>>>>>>>>>>>....>>>>>>.....<<<<<....>>>>>........>>>>>.....>>.>>>...>>>>>>>>......>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<..<.<<<<<<<<..>>>>>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>........ ...((((..[.[[[..)))).(((((((((..((((((.(((.....(((.(((..(((..((.(((((([[[[)))))).)))))......(((.......(((((((..((...(((((((.(((((....((((((....)))))).....)))))...(((((((((.((......))))))))))).....((((((((((]]..]])))))))))).)))))))..))))))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))....))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..(((((((.....)))))))..(..((((((.......)))))).....).((((([[....(.((((.....((..]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((.....(((((((.....)))))))...))))))))..)))))))))..(((((((.....((((((((((.((((((((...((........))......)))))))).))).......((....)).)))))))....))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((((.....))))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..((((((((((.................(((((.((.(((...(.((((((....(((((((((....)))..((((......))))..))))))....(((((.(((((((..(((.((((((((....)))))))))))...)))))))..(..(((((....))))).....)..)))))....))).)))....).)))))......)))))...)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((..(.((((((.(()).)))))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}....... Cryo-EM structure of the Pyrobaculum calidifontis 70S ribosome; 16S rRNA 9e7f 2 129 2.53 RF00001 0003735 0005840 410359 gccccuaacccggccauaggcgccggugcuacacccggucucaucagaacccggaaguuaaggccggcgccgcgcucgggaguacugggcuccgcgagggcccgggaaaccggcgugcugggagggggc <<<<<<..<<<<<<....<<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>>>><<<<.<<<.....<<<<<<.<<....>>>>>>>>....>>>>>>>>>>>>>.>>>>>> ((((((..((((((....(((((((((.....((((((...(....)...))))..))....)))))))))((((.(((.....((((((.((....))))))))....))))))))))))).)))))) Cryo-EM structure of the Pyrobaculum calidifontis 70S ribosome in complex with Dri; 5S rRNA 9e7f 1 2849 2.53 RF02540,RF02541,RF02543,RF00002 0003735 0005840 410359 uaggcaaagccgcccgguggauggcucggcucgggcgncgaagaagggcguggcaagcugcgauaagcccgggguagcngcaggcaggcuuagaacccgggauccccgaauggggcuuccugccggggccgaauaggccccggcgccccguaaggggcgggaacgcggggaaaggaaacaucuuaguacccgcaggaagggaagccaacagggacccccugaguaggggcgaccgaaagggggauagcccaaaccaaauccucgcgggacaaccguggggagauguggggcuugggcccgggcaaccgccggcgggcgguagccgaagugggcuggaaugccccgccguagagggugauagccccguaggcgaaaccgcccguggcggagucccggggucccggaguaccucggcuuaguuuugccgggggaacgcgccggccacuggccggcaaggcuaagcacgucccgaguccgauagcgcacuaguanngugagggaaagcugaaaagaaccccggaaggggggugaaaagagccugaaaccgggcggcuacaguggggcaggcccgaaaggaugcccccucccgaaggaaaccccggugacgggggaguacgagggaggggguccagggucugcccuuacgucuagaaacacgggccggggaguucanggccguggcgagccuaagggguucaaccccggaggcguagggaaaccgacagcccgcagcggggcaacccgcgaggggcggggucuuaaagggcccguagucacggccgugagaccagaaaccgggcgaucuagcccugggcagggugaagcggggcgaaagccccguggaggcccgaagggguucugaugugcaaaunguncccaugaccuggggcuaggggcaaaanaccaancaagcccggugauagcugguuccccccgaagcgggucucagcccggccuccccggaggcggccggcgggguagaguacugaucggggccccggucaaacuccgaaccugccagcgccguagaaggggggaggcgggggcggugggguaagccuccgcuccgagacgggaacaaccgagaccgggguuaaggcccccaagugcgggcuuagugucaaucuaaaagggcgucccccgcccaagacagccgaggcggggggccccgaagauguacagggacuaagcccgccgccgagaccccggcccgcgggccguuggcccgcgugggguaggggggcgcggccguggggcagaagccgggccgugagguccgguggacccgcggccgacgaagaucccggcgguaguagcagcgaagaggggugagaagccccuccgccggaaaggaccaggguuuccuggcaacuucaauaggccaggaguuagccgguccuaaggcggggccuaauaggcacccgccgaaagggaaacggguuaauauucccgugccgcggggguagguucugcggcaacgcaggccccguccccgacgccucgggauagggcgggcgggacugccgucccgcuuaaccgucgaaggccggggagugccguaauggcgagaaccggccgaaggcgggaauagccggggguuuccccgguccgcccgacuccuggggcccgugaaaaggggacggggaacgagcccccgcgcccguaccgagaaccgacgcaggugcuccugggugagaagcccaaggcggcucgggugaccccgggccagggaacunggcaaauuggccccguaacuucgggagaaggggugccugcggucuugggguauacccccgggaccgcaggucgcaguggcaagggggaccugacuguuuaacaaaaacauagguccccgcgagcccguaangnuguguacnggggcugaauccungccanuggcgguacguganccccggguacaaccgggcgangcgcnnnugaaggccggggguaacugacccucuuaagguagcnaanugccuunccggnuaagunccggcgugcangaauggaucaacgannuccccacugunncggcccggggcccggcgaacccaccuncaggugcacagnccugggacccccgacggggcnagaagucccuauggagcuucacagcagccugucguugcggguccgcuuacccgccgcaaggcggggacagcggcaggcgggcuguucggcugnggcngcacaccccugaaaagauaucnggggugcccaaagcucggcncaggcgggucagaaauccgccguagaguguaagggcaaaagccgggcugacugggcccuugaacgcaaggggcccaggcgggaaaccggggccuagagaacgcucgugcccccaccagugggggccggnnaugacagaaaaguuacncuaggaauaaccggcucgncgcgggugagaguccccaucgaccccncgguuunguacccagacgucgnnucuncccauccuggcggugcagcagccgccaaggguggggcnncccgcccauuaaaggggaacgugngaugggnucagancgncgcgagacaggunggucucuaccugucgggggcgcuggccgccugaggggaaggugcccucaguacgagaggaacggggcgccgcggccucuaguguaccgguuguccggcagggcacugccgggcagccacgccguggggganaaccgcugaaagcaucuaagcgggaagcccucnncgagacgaggcggccguugcccugggggcaaccccggggcacgagggcuccnguagaagacgggguugaugggggggcgguguaacccccgaggguuucccgaggggagagccggccccucccaaucgcccgagcgunc ..<....<<<<<<<<<<<....[((..((<<<<<<((<<......<<<<<<.((..((.>>>.....<<<<<<...<<<))..)).>>>......>>>>>>...>>>....<<<....>>><<<<<<<<<.....>>>>>>>>><<<<<....>>>>>>>...<<<<<<....<<<....>>>.....>>>>>.>.........<<....>>...<<<<<.....<<.....>>....>>>>>...<<<....<<<..<<<<<<<<<.....>>>>>>>>>....>>>.....<<<<<<<<<...<<<<<.<<<<<<<<<.<<<.....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>...>>>>>>..>>>......<<<<<<<........>>>>>>>......<<<<<.<<<<<<>>>>>..>>>......)).>>>>>>.))...............<<....>>....)).........<<<<....>>>>............]....>>>>>>>>>>>.....<<<<<<<<<<<....<<..<<<<<<<<<<...<....<<<<<....>>>>>.....>..>>>>>>>>>>>>.>>>>>>>>>>>..<<<........>>>.<<<<<<....<<<<<<<<<<<<<..<<<...<<<<<...>>>>>...>>>...<<....>>....<<<<...<<<<<....>>>>>...>>>>.<<<<<<....>>>>>>...>>>>>>>>>>>>>..<<<<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<.....<<........>>...>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>>>>..<<<<<<....<<<<<....>>>>>.<<<<<<<...<<<.<<.<<<<<<...<<<...<<<<<<<<..>>>>>>>>..>>.>...>>>>>>.>>>>>......>>>>>>.>...<<<<<<<.<<<.....>>>>>>>>>>....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<............>>>>>>>>>>>>>...........)))>>...>>>>>>.>>>...>>>>>>><<<<<<<<<<...>>>>>>>>.>>....>>>>>><.<<<<<<<<<<......<<<<<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<......<<<<<<.......>>>>>><<<<.....<<<...<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<<<<<<<<.....>>>.>>>>>>....>>>..<<<<<........>>>>>))<<<<<<<<........<<<....>>>...<<<<<<<<<<...<<<<<<<<<..<<<<<<<<<<<<<.(((>>>>>>><...<<<<<...<<<<<<.....<<<<...>>>>.....>>>>>>...>>>>>....><<<<<<<<..>>>>>>>>>>>>>>...>>>>>>>>>.........>>>>>>>>>>......>>>>>>>>.>>>..>>.....<<......>>...>>><<<<<.....>>>>>.>>>>...<<<<<...<<<<<<<<.<<...............<<<<<....<....>.....>>>>><<<<<<<<<<<<<<<<.....>>>>>>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<....>>>>......>>>>>>>..<<<<.<<<..<<<<<<<..<<<....<<<<<......>>>>>....>>>>>>>>..>>>>><<<<<<.....>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>...>>.>>>>>>>.....>>.>>>>>>>>>>>>>>>....>>....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<<<<<<<.<<<<..>>>>...<<<<<<....>>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<<<<<<.........>>>>>>>>>.<<<....>>>.>>)))]......<<<<<...<<<<.>>>>>>>>>>.>>>>>..........>>>>..]]>>>>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>..<<<<.....>>>>......>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<<...............>>>>>>>><<<<<...<.<<...<<<<<<<<<<))).>>>>>..>>>>>...>>.>.>>>>>.<<<<.<..<<<<<...........>>>>>...>>>>>>>>>.......>>>>>>>..<<<<<<<<<<....>>>>>>>>>>...<<<<<<<<<.......>>>>>....<<<<<<<<<<<<.....<<<<..<<.....>>..>>>>...>>>>.>>>>>.>>>...>>>>...>.... ..(.....(((((((((.....(((..((((((((((((......((((((.[[..[[.))).....((((((...(((]]..]].)))......))))))...)))....(((....)))(((((((((.....)))))))))(((((....)))))))...((((((....((...[..)).....))))).)...(.....((....))...(((((.....((.]...))....)))))...((((...((..((((((((((.....)))))))))....))).....((((((((((.[(((((.(((((((((.(((...({((((......)))))[[(...).(((....}]])))...)))...)))))))))))))).)]))))))..))).)....(((((((........)))))))......(((((.[[[[[[)))))..)))....).)).)))))).))...............((....))....))......(..((((....))))...........)).....)))))))))......(((((((((((....((..((((((((((...(....(((((....))))).....)..)))))))))))).)))))))))))A.(((........))).((((((....(((((((((((((..(((...((((.....))))...)))...((....))..(.((((...(((((....)))))...)))))((((((....))))))...)))))))))))))..((((...((((((.....((((((((((.((((...(((((((....)))))))...)[)))...(((...(.((.......B)))..)))..).))))))))).(.((.......))...)..))))))......))))..((((((....(((((....))))).(((((((...(((.((.((((((...(((...((((((((()))))))))..)).)...)))))).)))))......)))))).)...(((((((.(((.....))))))))))....(((......)))...(((((((...((([[[...(.((((((.....((..........(((.((((((((((.....<......)))))))))))))...........]]]))...))))))))))...)))))))((((((((((...)))))))).))....))))))(.((((((((((......((((((((....))))))))...))))))))))..).....))))))((.....((......((((((.......))))))((((.[...(((...((..(((((((...((.....)).))))))....[[(((.((...(((((((((.....))).))))))....))...(((((........)))))]]((((((((..(.....(((....)))...((((((((((...(((((((((..((((((((((((..{{{.))))))(...(((((...((((((.....(((.....))).....))))))...)))))....)((((((((..))))))))))))))..])))))))))(...)....))))))))))..)...)))))))).))).))).....((......))...))).((((.....))))..))))...(((((...((((((((.((..(....(.......(((((....(.{..).....)))))((((((((((((((((.....))))))))))))))))(...).......(((((((((.].((.........))...(((((((....((((....))))......))))))).}.(((.(((..(((((((..((.....(((((......))))).....)))))))..)))))(.((((.(.).)))).)........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))))))))))....))[[..(((((.....a]])))))..((((((((.(((.((......((((.((((((..(((((.(((((((((.((((()))))...((((((....))))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...(((((((((.........))))))))).(((....))).))]]].].....(((((.(.((((.]]]]]]))))))))))....).....))))..)))))).......(.(....((((((...((.......))...)))))).....)..)........((((.((((((..(((((((((......))))))..)))..((((.....))))......)))))..)...))).).....(((((((....))).))))..b.))..)))))))))))[...(((((((...((((..((((((((.....(....)....))))))))(((((...(.((...((((((((((}}}.)))))..))))).{.)).).))))).((((....((((.....>.......))))....))))))))..]....)))))))..((((((((((....))))))))))(..((((.((((.......)))).....((((((((((((.....((((..((.....))..))))...))))}))))).)))...))))..)).... Cryo-EM structure of the Pyrobaculum calidifontis 70S ribosome in complex with Dri; 23S rRNA 9e7f 4 1430 2.53 RF01959,RF00177,RF02542,RF01960 0003735 0005840 410359 aaacngnuugauccngccngacccgaccgcuaucggggungggcuaagccaugcgagucgcgcgcccgggggcgcccgggagcggcgcacggcucaguaacacgugccuaaccuaaccucgggagggggacacccccgggaaacuggggucaaucccccauaggggaagggcgcuggaaggccccuuccccgaaagggcuggcggccgauccgccgccagucgcccgagggugggggcacggcccaucagguaguuggcggguuaaaggcccgccaagccgaagacggguaggggcggugagagccgcgagccccgagaugggcacugagacaagggcccaggcccuacggggugcagcaggcgcgaauacuccgcaaugcgggcaaccgcgacggggcuaccccgagugccgggcgaagagcccggcuuuugcccggucuaaaaagccgggagaauaagcnggngncaagucungugucagccgccgngguaaunccagcuccgcgngungungggguguuuacugggcuuaaagcgcccguagccggcccggcaagucgcuccuganauncccgggcucaacccgggggccgggggcgauacugccgggcuagggggcgggagaggccgccgguacuccggggguaggggcgaaauccguuaauccccggangaccaccaguggcgaaagcgggcggccagaacgcgcccgacggugaggggcgaaagccgggggagcaaaggggauuagauaccccuguagucccggccguaaacgaugcgggcuagcugucggucgggcuuagggcccggccgguggcgaagggaaaccguuaagcccgccgccuggggaguacggccgcaaggcugaaacunannggaauuggcgggggggcaccacaagngnugaagcuugcggcuuaauuggaaaaccucacccgggggaggugcauggccgucgucagcucgugnngugagguguncgguuaaguccggcnacgagcgagacccccgccccuaguugcuaccccucccuacggggaggggggcacacuagggggacugccggcguaagccggaggaaggagggggccacggcangucaguaugccccgaaacccnggggcugcacgcgagcuncaauggcnnngacagcgggauccgaccccgaaagggggaggcaaucccguaaaccccgccccaguagggaucgagggcugcaacucncccucgugaacguggaaucccuaguaacngcgugucaccaacgcgcggugaauacgucccugccccuugcacacaccgnccgucgcaccacccgagggagcccucugcgaggccccucgccgguggggggacgagcagggggcucccaaggggggugaagucguancaagguagcnguaggggnnccugcggcuggaucacc ...<<<<..[.((((.>>>>.<<<<<<<<<..<<<<<<.<<......<<<.<<<..<<<..<<.<<<<<<((((>>>>>>.>>>>>......<<........<<<<<<<..<<.<.<<<<<<<.<<<<<....<<<<<<....>>>>>>.....>>>>>...<<<<<<<<<.<<......>>>>>>>>>>>.....<<<<<<<<<<))..))>>>>>>>>>>.>>>>>>>.>>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>....>>>>.>>.<<<<<............>>>>>.<<<<<..>>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<<<<.....>>>>>>>.....<<<<<<.......>>>>>>.......<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<....<<<<<<<<.....>>>>>>>>..>>>>>>>>..>>>>>>>>>...<<<<<<.....<<<<<<<<<..<<<<<<<<<..<<<......>>>.....>>>>>>>>>..>>.......<<....>>.>>>>>>>....>>>.>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<..<<<<<<<<<<<<<<.....>>>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<.<<<<<<..<<<<<<<<<<.................<<<<<.<<.<<<..<<<<<<<<.....<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>....<<<<<.<<<<<<<..<<<.<<<<<<<<....>>>>>>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>>.....>>.>>>...>>>>>>>>......>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<..<.<<<<<<<<..>>>>>>>>.>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>........ ...((((..[.[[[..)))).(((((((((..((((((.(((.....(((.(((..(((..((.(((((([[[[)))))).)))))......(((.......(((((((..((...(((((((.(((((....((((((....)))))).....)))))...(((((((((.((......))))))))))).....((((((((((]]..]])))))))))).)))))))..))))))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))....))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..(((((((.....))))))).....((((((.......)))))).......((((([[....(.((((.....((..]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((.....(((((((.....)))))))...))))))))..)))))))))..(((((((.....((((((((((.((((((((...((........))......)))))))).))).......((....)).)))))))....))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((((.....))))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..((((((((((.................(((((.((.(((...(.((((((....(((((((((....)))..((((......))))..))))))....(((((.(((((((..(((.((((((((....)))))))))))...)))))))..(..(((((....))))).....)..)))))....))).)))....).)))))......)))))...)).)))))))).(...(((((((.....(((..((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((((((((((((..(.((((((.(()).)))))).)..)))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}....... Cryo-EM structure of the Pyrobaculum calidifontis 70S ribosome in complex with Dri; 16S rRNA 9ere T 52 2.82 39627193 9606 caggauggccgaguggaaggcaauggacguccgcguggguucgaaccccacu .......<<<........>>>...<<<..>>>..<<<<<.......>>>>>. ....(..(((.....[..)))...(((())))..(((((..]....)))))) SLFN11 dimer bound to tRNA-Leu-TAA; RNA (76-MER) 9erf T 48 2.64 39627193 9606 cagaguggcgcagcggaagcgugcgaggucgauggaucgaaaccaucc .......<<<<.......>>>>.<>.....<<<<<.......>>>>>. ....(..((((....[..)))).().....(((((..]....)))))) SLFN11 dimer bound to tRNA-Met-CAT; RNA (65-MER) 9esh 1 29 3.2 39833470 4896 uuuuuauuaaaaaaugguauguuuuuuuu ............................. ............................. Structure of a B-state intermediate committed to discard (Bd-I state); pre-mRNA 9esh 2 24 3.2 39833470 4896 ucucucuuugccggcuuagaucaa ........................ ........................ Structure of a B-state intermediate committed to discard (Bd-I state); U2snRNA 9esh 5 102 3.2 RF00020 39833470 0000244,0000353 0005682,0046540 4896 cgucaaagcacuuugcaaaagcuaacguaucuguuucuugccuuuuaccagaaacagccguuuguaaggugugcuaauuugacuguauaguuuuuguaaucu .<<<<<<<<<<<<<<<<<<...........<<<<<<<<...........>>>>>>>>...>>>>>>>>>>>>.....>>>>>>................... (((((((((((((((((((......((...((((((((.(.......).)))))))).)))))))))))))).....)))))).)................. Structure of a B-state intermediate committed to discard (Bd-I state); U5snRNA 9esh 6 92 3.2 RF00026 39833470 0030621 0000244,0000353 0005688,0046540 4896 gaucuucggaucacuuuggucaaauugaaacgauacagagaagauuagcauggccccugcacaaggaugacacugcgacauugagagaaaac <<<<....>>>>......................................<<...<<<.....>>>....>>.................... ((((....))))......................................((..((((.....)))..).)).................... Structure of a B-state intermediate committed to discard (Bd-I state); U6snRNA 9esi 2 24 3.1 39833470 4896 ucucucuuugccggcuuagaucaa ........................ ........................ Structure of a B-state intermediate committed to discard (Bd-II state); U2snRNA 9esi 5 102 3.1 RF00020 39833470 0000244,0000353 0005682,0046540 4896 cgucaaagcacuuugcaaaagcuaacguaucuguuucuugccuuuuaccagaaacagccguuuguaaggugugcuaauuugacuguauaguuuuuguaaucu <<<<<<<<<<<<<<<<<<<...........<<<<<<<<...........>>>>>>>>...>>>>>>>>>>>>.....>>>>>>.>................. (((((((((((((((((((......((...((((((((.(.......).)))))))).)))))))))))))).....)))))).)................. Structure of a B-state intermediate committed to discard (Bd-II state); U5snRNA 9esi 6 92 3.1 RF00026 39833470 0030621 0000244,0000353 0005688,0046540 4896 gaucuucggaucacuuuggucaaauugaaacgauacagagaagauuagcauggccccugcacaaggaugacacugcgacauugagagaaaac <<<<<..>>>>>......................................<<...<<<.....>>>....>>.................... ((((....))))......................................((..((((.....)))..).)).................... Structure of a B-state intermediate committed to discard (Bd-II state); U6snRNA 9esi 1 29 3.1 39833470 4896 uuuuuauuaaaaaaugguauguuuuuuuu ............................. ............................. Structure of a B-state intermediate committed to discard (Bd-II state); pre-mRNA 9f1b AT 76 3.01 39169182 9986 nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnncca ............................................................................ ............................................................................ Mammalian ternary complex of a translating 80S ribosome, NAC and NatA/E; P-site tRNA 9f1b B5 3706 3.01 RF02543 39169182 0003735 0005840 9986 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcgguggggcgcgggaaauguggcguacggaagacccacuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagngngaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcgugguccggccgugccggcggucucggcggaucuuucccgcuccccguuccuggggguggggucggcgggggaccgccccccggccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggccccggcggggaagguggcccggggggacgccucgccgccgucguccgcggcggcggcgggcgcgaccccuccccggguguuacagccccgccccggcagcagcagcucgccgaaucccggggccgagggagcgagaccugugucgccgcgcucuccccccucgggggggccgggccgccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgugucacgccgucgggcucgggggaggccacggcgcgucgcgcgccggcgcgcgcgcgcgagcgagcgcacggggucggcggcgaugucggcuacccacccgacccnucuugnaacncggaccaaggagunuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcggcggcgccgucgucggccgaggugggaucccgaggcccuuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccnanagauggugancuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauagnggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcaaccccgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcngaacuggcgnugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgcuggcagucggcagagcgagaaagagaguggagccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaunuuggugguagunnnaaauauucaaacgagaacuuugaaggccgaaguggngaaggguuccaugngaacagnanuugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucagccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccnuauccgcagcaggucuncaaggugaacngccucuggnauguuggaacaanguagguaagggaagucggcaagcnggauccguaacuucnggauaaggauuggcucuaagggcugguagcagccgacuuagaacuggugcggaccaggngaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugccnagugcucugaaugucanagugangaaauucaaugaagcgcggnuaaacggcgggaguancuaugacucucuuaagguagcnaanugccucnucaucuaauuagugangcgcaugaanggaugancgagnuucccacugunccuaccuacuauccagcgaaaccacngncaagggaacgggcuuggnggaaucagcggngaaagaagacccuguugagcuugacncuagucuggcacggugaanagacacguuuuuucacugacccggugaggcgggggggcgagccccgaggggcucucgcuucuggcgccaagcgccgggccccgucgguccgggccggcggcggccgggcgcgacccgcuccggggacagugccagguggggaguuugacugnggcgguacaccugucaaacgguancgcaggnnuccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucagnacgaauacagaccgugaaagcggggccucacgauccuucugagcuuuuggguuuuaagcaggangugucagaaaaguuaccacagngauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuungaugucggnucuuccuaucauugugaagcagaauucaccaagcguungaunnuucacccacuaauagggaacgugngcugggnuuagancgucgugagacagguuaguuuuacccuacugaugnuguguuguugccaugguanuccugcucaguacgagaggaaccgcagnuncanacauuugguguaunugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgaaggagccucgguuggccucggauagccggucccccgcgggguccggugcggagagcccuucgucccgggaaauggggcgcggccggaaagggggccgcccucucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>>..<<<<<<<<<....<<<<<<<<.<<<....<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>>>>>>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<......>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<<....<<<<<<<.<<<<<.<.....<<<<<.<<<..<<<<<<<<<<<<<.<...>>>>>>>>..>>>>>>>>>>>>>>.>>>>>>>>>>...>>>.>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<.<<<<<<<<<<.<<<<...<<..<<<..<<<<<<<......<<<<<<<<<<....<<<<<<<<<<<<<<..>>>>>>>>>>>>>>........>>>>>>>>>>.......>>>>>>>..>>>.........>>>>>>...>>>>>>>>>>.....<<.....[[>>......<<<<<<.<<<<<<<.>>>>>>>.<<<<<<.<<<<.<<<<<<<<<.<<<<<<<<<<<<<<.<<<<....>>>>.>>>>>>>>>>>.>>>.>>>>>>.>>>...>>>>..>>>>.>><<<<<.<<<<<<<..>>>>>>>>>>>>....>>>>>>......>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<<<<<<..>>>>>>>>>>>>..<<<<<...<<<..<<....((((.{{..>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<..........<<<.<<<<<<<<<...<<<....<<<..<.<<<..<<<<<<.<.....>.>>>>>>>>>.>..>>>..>.>>...>>>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<.......]]...........}}.))))..............>>>>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<<<<<...>>>>>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<...<<<<<<<....>>>>>>>...<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<....>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<<<<..>>>>>>>>>>...<<<<<.....<<<<..<<.<<<<<<<..>>>>>>>>>..............<<<<<.<<<<.<<<<<<<<..>>>>>>>>..>>>>.>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>>.<<<....>>>.>>)))].....<<<<<<<..<<<..)))))).>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<]]].>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.....<<<<<<<..<<..<<<<....<<<........<<<<<..<<<<..>>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<........>>>>>>>>>>...>>>>..>>>..............>>>>..>>>>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<.<..<<<<<......>>>>>..>>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..(((((((((((.....)))))).))))....))))....(((((((((....((((((((.((.....((((((((..({((((......)))))....[[(...).(((....}]])))...).))))))).))))))))))...)))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....((((((((((.(..(((((((.(((((.((....(((((.((...(((((((.(((((((()))))))).)..)))))).))))))))))))))))))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((..(((((((......((((((((((...((((((((((((((....))))))))))))).)......)))))))))).......)))))))..))).........))))))..))))))))))).....((.....{{))......((((((.(((((((.))))))).((((((.((((.(((((((((.((((((((((((((.((((....)))).))))))))))).))).)))))).)))...))))..)))).))(((((.(((((((()))))))))))))..[.)))))).....))).)))))...)))))...)))))))).<((((........))))((((((....(((((((((((((..(((..((((..........)))..)..)))...((....))...((((((((((((()))))))))))))..(((((...(((..((.(].[[[[.[[[)))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((........)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((..........(((.((((((((.....((.....((.....((...(((((.(.....).))))).)).....))...))......))))))...(((((((((.(......))))))))))....))))))))))))..))..((((..(.((.....)).)..))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.....A.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((.......}}.........].]].]]]].(...)........)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((..(((((((...((.....)).))))))....[[(((.((...(.....(((....)))...(.)....((.(((((((((...))))))))))).......)....))...(((((........)))))]]((((....(((((...((.((((....)))).))..((((....)))...(...((((((...((((((((((((((((((((((...{{{...)))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).))).))).....((......)).)))).((((.....))))..)))....(((......((((((..((..(....(.......(((((....(.[..).....)))))((.(((((((((((....)))))..)))))).))(...).......(((((((((.>.(...........)...(((((((....((((.....))))......))))))).].(.(.(((..((((((.(...(......((.(....).))......).)))))..)))))(.(.(.........).).)........((..........(((((.......)))))..)..)....).)....)).))))))).)..)))..))))))...)))))....)).[..((.((.....>].)).))....(((((..(((.((......((((.(((((...(((((.(((((((((.(((((.(((....))).)))))...(((((.....((((..((.(((((((..)))))))))..............(((((.((((.((((((.(()).))))))..)))).)))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(..((....((....{..))....)).)(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}.....)))..)))))).......(....(.((((.(...((.......))...).))))...)....)........((((.((((((..(.(.(.(((......))).)...).).(((.(.....).))).....)))))..)...))).)......((((((....))).))).....))..))).))))).....(.((.(.(..(((..(.(((((......(....).....))))).)(((.....((((....((.(((((((}}}.)))))..)).))...))))....))).((((...((((.....a.......))))...))))..)))...).).)).).....(((((((..((..((((.(..(((.........((((..((((())))).))))........)))...(((..((((....((((.((((((........))))))))))...))))..)))...........)..))))..)))))))))(((((....(.......).......((.(((((((.((.....(.((.(..(((((......)))))..))).)....))....)))).))).))..))))).. Mammalian ternary complex of a translating 80S ribosome, NAC and NatA/E; 28S rRNA 9f1b B7 119 3.01 RF00001 39169182 0003735 0005840 9986 ucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>... ((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))... Mammalian ternary complex of a translating 80S ribosome, NAC and NatA/E; 5S rRNA 9f1b B8 156 3.01 RF00002,RF02540 39169182 0003735 0005840 9986 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauuncaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<<<<....>>>>.....<.<<<......>>.............>>>..>...>>>....<<....>><<<<<<<<<.....>>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))(((((((((.....))))))))).................... Mammalian ternary complex of a translating 80S ribosome, NAC and NatA/E; 5.8S rRNA 9f1b A2 1770 3.01 RF01960,RF02542,RF01959,RF00177 URS00023119C9_9986 39169182 0003735 0005840 9986 uaccugguugauccugccaguagcaunugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucnuuaaaucaguuauggunccuunggucgcucguacuuggauaacugugguanuucuagngcuaananaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucagaucaaaaccaacccggugccggcggcuuuggugacucuagauaaccucgggccgaucgcacgcccuccguggcggcgacgacccauucgaacgucngcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgaunccggaganggagccugagaaacggcuaccacauncaaggnaggcagcaggcgcgcnaauuacccacucccgacccggggangungugangaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaanuccuuuaacgaggnuccauuggagngcaagucuggugccagcagccgcggnaauuccagcuccaauancguauauuaaaguugcugcaguunaaaagcucguaguungaucuugggagcgggcggccgcccguccccgccucucggcgccccggggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaaungaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagancgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacncaacacgggaaaccucacccggcccggacacggacagganugacagauugauagcucuuucucgauuccguggguggngnugcauggcnguucuuaguugguggagcgauuugucugguuaauuccgauaacgancgagacunuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuncuuanagggacaaguggcguucagccacccgagauugagcaauaacangucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgagnaauucccaguaagugcgggucauaagcuugcguugauunagucccugcccuuuguacacaccgnccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggucggcccacggcccuggcggagcgcugagaagacggucgaacungacuaucuagaggaaguaaaagucguancaagguuucnguaggugnnccugcggaaggaucauua ...<<<<<...[[[[>>>>>[[[.((((((.....{{.........[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[......{{....[[[[[.........<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<<<....>>>>>>...>>>>[[..(((((.....<<<<<<<<<<<<<..>>>>.......<......>..)))))......]]...<<<<.<<<<......>>>>>>>>.]].]]]...}}....]]].<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<<...>>>>..>>>......}}.......<<<<<<<<<.<<<....>>>..>>>>>>.>>>......<<..<...........>..>>.........<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..)))))).]]]............{{.......{{...[[[.[[....<<<.<<<<<<<..>>>>>>>.>>><<...<<<..<<<<<>>>>>.>>>.>>..<<<<<<.<.......<<...<.......>.<<<<.......>>>>...>>......>.>>>..>>>........{.[[.(((((((.....>>>>>>>>>.))))))).]].}....]]....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<<....>>>>>>>>>>>.>..>>>...<<..}}>>...>>.....>>>.....<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<........<<........>>..........<<<<<.<....<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<.......>>>>.>>>>.....>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.....>.>>>>>......>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<<<<<<<<<<<<<<.....>>>>>>>>>>>>.>.>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... ...((((..[.[[[..))))((...(((((......(..((.....(((.(((..((....((....((..........))...)){))......(((.......(((.(....((....(((.....(({...((.....((.(((.....))).))......))......)).((((...((((((....))))))...))))((..(((((.....[[[[[[[[[.(((())))........(......)..)))))......)).(}((((.((((......)))))))))...)))...))..).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)...)........(((((((((.(((....)))..)))))).)))....(.((..(...........)..))......)..((((([[....(.(.((.....((..]])).......)).)))))))..)))))...))..{......(.({{...(.(.((...(.(.((....(((.(((((((()))))))).))).(.....(..((((())))).)...)...(..(((.(........(..((.......)).((((...)..)))....).......).)))....)........(.((.(((((((.....]]]]]]]]].))))))).)).)....))...(((..(...(...(((...((..((((((((...(..........)......))))))))..)).......((....))....)))..)...)...))..)).)...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..(.((((((.(((((....))))))))))).)..)))...((..}}))...))...}.))))).).(((......((.(....).))....)))...]]].]((((..(((((((..((..((.((..(((..(((((.......(........)...........(((((.(....(((((........(..(((........)))..)......)))))...((.(((...(.((((((....((..(((((....)))..(.((......)))...))..))....(((...(...((.(..(((((((((((((....).)))).)))).....))))..).))..).....(((((.....)))))........)))....))).))).....).))))).....).)))))...)).)))..))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....((((............)))).....)..)..)).)).....((((((((.......))))))))......))...))))))).)).))..(.(..((.(..((((.((..(.((((((((.(((..((((.((...(((((((((.(.((((((.....)))))).).))).).)))))...)).))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>........ Mammalian ternary complex of a translating 80S ribosome, NAC and NatA/E; 18S rRNA 9f1c B7 119 3.78 RF00001 39169182 0003735 0005840 9986 ucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>... ((((((((....((((((((.....((((((...(....)...))))..))....)))))).))(((.((......((.((..((....)).)).)).....)).)))))))))))... Mammalian quaternary complex of a translating 80S ribosome, NAC, MetAP1 and NatA/E; 5S rRNA 9f1c AT 76 3.78 39169182 9986 nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnncca ............................................................................ ............................................................................ Mammalian quaternary complex of a translating 80S ribosome, NAC, MetAP1 and NatA/E; P-site tRNA 9f1c B8 156 3.78 RF00002,RF02540 39169182 0003735 0005840 9986 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauuncaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<<<<....>>>>.....<.<<<......>>.............>>>..>...>>>....<<....>><<<<<<<<<.....>>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))(((((((((.....))))))))).................... Mammalian quaternary complex of a translating 80S ribosome, NAC, MetAP1 and NatA/E; 5.8S rRNA 9f1c B5 3706 3.78 RF02543 39169182 0003735 0005840 9986 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcgguggggcgcgggaaauguggcguacggaagacccacuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagngngaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcgugguccggccgugccggcggucucggcggaucuuucccgcuccccguuccuggggguggggucggcgggggaccgccccccggccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggccccggcggggaagguggcccggggggacgccucgccgccgucguccgcggcggcggcgggcgcgaccccuccccggguguuacagccccgccccggcagcagcagcucgccgaaucccggggccgagggagcgagaccugugucgccgcgcucuccccccucgggggggccgggccgccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgugucacgccgucgggcucgggggaggccacggcgcgucgcgcgccggcgcgcgcgcgcgagcgagcgcacggggucggcggcgaugucggcuacccacccgacccnucuugnaacncggaccaaggagunuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcggcggcgccgucgucggccgaggugggaucccgaggcccuuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccnanagauggugancuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauagnggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcaaccccgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcngaacuggcgnugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgcuggcagucggcagagcgagaaagagaguggagccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaunuuggugguagunnnaaauauucaaacgagaacuuugaaggccgaaguggngaaggguuccaugngaacagnanuugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucagccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccnuauccgcagcaggucuncaaggugaacngccucuggnauguuggaacaanguagguaagggaagucggcaagcnggauccguaacuucnggauaaggauuggcucuaagggcugguagcagccgacuuagaacuggugcggaccaggngaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugccnagugcucugaaugucanagugangaaauucaaugaagcgcggnuaaacggcgggaguancuaugacucucuuaagguagcnaanugccucnucaucuaauuagugangcgcaugaanggaugancgagnuucccacugunccuaccuacuauccagcgaaaccacngncaagggaacgggcuuggnggaaucagcggngaaagaagacccuguugagcuugacncuagucuggcacggugaanagacacguuuuuucacugacccggugaggcgggggggcgagccccgaggggcucucgcuucuggcgccaagcgccgggccccgucgguccgggccggcggcggccgggcgcgacccgcuccggggacagugccagguggggaguuugacugnggcgguacaccugucaaacgguancgcaggnnuccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucagnacgaauacagaccgugaaagcggggccucacgauccuucugagcuuuuggguuuuaagcaggangugucagaaaaguuaccacagngauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuungaugucggnucuuccuaucauugugaagcagaauucaccaagcguungaunnuucacccacuaauagggaacgugngcugggnuuagancgucgugagacagguuaguuuuacccuacugaugnuguguuguugccaugguanuccugcucaguacgagaggaaccgcagnuncanacauuugguguaunugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgaaggagccucgguuggccucggauagccggucccccgcgggguccggugcggagagcccuucgucccgggaaauggggcgcggccggaaagggggccgcccucucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>>..<<<<<<<<<....<<<<<<<<.<<<....<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>>>>>>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<......>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<<....<<<<<<<.<<<<<.<.....<<<<<.<<<..<<<<<<<<<<<<<.<...>>>>>>>>..>>>>>>>>>>>>>>.>>>>>>>>>>...>>>.>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<.<<<<<<<<<<.<<<<...<<..<<<..<<<<<<<......<<<<<<<<<<....<<<<<<<<<<<<<<..>>>>>>>>>>>>>>........>>>>>>>>>>.......>>>>>>>..>>>.........>>>>>>...>>>>>>>>>>.....<<.....[[>>......<<<<<..<<<<<<<.>>>>>>>.<<<<<<.<<<<.<<<<<<<<<.<<<<<<<<<<<<<<.<<<<....>>>>.>>>>>>>>>>>.>>>.>>>>>>.>>>...>>>>..>>>>.>><<<<<.<<<<<<<..>>>>>>>>>>>>.....>>>>>......>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<<<<<<..>>>>>>>>>>>>..<<<<<...<<<..<<....((((.{{..>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<..........<<<.<<<<<<<<<...<<<....<<<..<.<<<..<<<<<<.<.....>.>>>>>>>>>.>..>>>..>>.>...>>>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>>>>>>.>>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<.......]]...........}}.))))..............>>>>>>>>>....>>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<<<<<...>>>>>>>>>>>......>>....>>>...<<<<........>>>>.))<<<<....<<<<<...<<<<<<<....>>>>>>>...<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<...............<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<....>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<<<<..>>>>>>>>>>...<<<<<.....<<<<..<<.<<<<<<<..>>>>>>>>>..............<<<<<.<<<<.<<<<<<<<..>>>>>>>>..>>>>.>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>>.<<<....>>>.>>)))......<<<<<<<..<<<..)))))).>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<]]].>>>>>..>>.>>...>>>>...>>>><<<<....<<<<<...........>>>>>....>>>>.>>>...>.>>>>>>.....<<<<<<<..<<..<<<<....<<<........<<<<<..<<<<..>>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<........>>>>>>>>>>...>>>>..>>>..............>>>>..>>>>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<.<..<<<<<......>>>>>..>>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..(((((((((((.....)))))).))))....))))....(((((((((....((((((((.((.....((((((((..({((((......)))))....[[(...).(((....}]])))...).))))))).))))))))))...)))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....((((((((((.(..(((((((.(((((.((....(((((.((...(((((((.(((((((()))))))).)..)))))).))))))))))))))))))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((..(((((((......((((((((((....(((((((((((((....)))))))))))))........)))))))))).......)))))))..))).........))))))..))))))))))).....((.....{{))......((((((.(((((((.))))))).((((((.((((.(((((((((.((((((((((((((.((((....)))).))))))))))).))).)))))).)))...))))..)))).))(((((.(((((((()))))))))))))..[.)))))).....))).)))))...)))))...)))))))).<((((........))))((((((..(.(((((((((((((..(((..((((..........)))..)..)))...((....))...((((((((((((()))))))))))))..(((((...(((..((.(].[[[[.[[[)))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((........)))).)))..).))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((.(((((((..........(((.((((((((.....((.....(......((...((.(..(.....)..).)).))......)...))......))))))...(((((((((.(......))))))))))....))))))))))))..))..((((..(.((.....)).)..))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.....A.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((.......}}.........].]].]]]].(...)........)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((..(((((((...((.....)).))))))....[[(((.((...(.....(((....)))...(.)....((.(((((((((...))))))))))).......)....))...(((((........)))))]]((((....(((((...((.((((....)))).))..((((....)))...(...((((((...((((((((((((((((((((((...{{{...)))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).))).))).....((......)).)))).((((.....))))..)))....(((......((((((..((..(....(.......(((((....(.[..).....)))))((.(((((((((((....)))))..)))))).))(...).......(((((((((.>.(...........)...(((((((....((((.....))))......))))))).].(.(.(((..((((((.(...(......((.(....).))......).)))))..)))))(.(.(.........).).)........((..........(((((.......)))))..)..)....).)....)).))))))).)..)))..))))))...)))))....)).[..((.((.....>].)).))....(((((..(((.((......((((.(((((...(((((.(((((((((.(((((.((((..)))).)))))...(((((.....((((..((.(((((((..)))))))))..............(((((.((((.((((((.(()).))))))..)))).)))))..))))..)))))....)))))))))..)))))..(((......[)).)(((((...........].)))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(..((....((....{..))....)).)(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}.....)))..)))))).......(....(..(((.(...((.......))...).)))....)....)........((((.((((((..(.(.(.(((......))).)...).).(((.(.....).))).....)))))..)...))).)......((((((....))).))).....))..))).))))).....(.((.(.(..(((..(.(((((......(....).....))))).)(((.....((((....((.(((((((}}}.)))))..)).))...))))....))).((((...((((.....a.......))))...))))..)))...).).)).).....(((((((..((..((((.(..(((.........((((..((((())))).))))........)))...(((..((((....((((.((((((........))))))))))...))))..)))...........)..))))..)))))))))(((((....(.......).......((.(((((((.((.....(.((.(..(((((......)))))..))).)....))....)))).))).))..))))).. Mammalian quaternary complex of a translating 80S ribosome, NAC, MetAP1 and NatA/E; 28S rRNA 9f1c A2 1770 3.78 RF01960,RF02542,RF01959,RF00177 URS00023119C9_9986 39169182 0003735 0005840 9986 uaccugguugauccugccaguagcaunugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucnuuaaaucaguuauggunccuunggucgcucguacuuggauaacugugguanuucuagngcuaananaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucagaucaaaaccaacccggugccggcggcuuuggugacucuagauaaccucgggccgaucgcacgcccuccguggcggcgacgacccauucgaacgucngcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgaunccggaganggagccugagaaacggcuaccacauncaaggnaggcagcaggcgcgcnaauuacccacucccgacccggggangungugangaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaanuccuuuaacgaggnuccauuggagngcaagucuggugccagcagccgcggnaauuccagcuccaauancguauauuaaaguugcugcaguunaaaagcucguaguungaucuugggagcgggcggccgcccguccccgccucucggcgccccggggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaaungaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagancgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacncaacacgggaaaccucacccggcccggacacggacagganugacagauugauagcucuuucucgauuccguggguggngnugcauggcnguucuuaguugguggagcgauuugucugguuaauuccgauaacgancgagacunuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuncuuanagggacaaguggcguucagccacccgagauugagcaauaacangucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgagnaauucccaguaagugcgggucauaagcuugcguugauunagucccugcccuuuguacacaccgnccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggucggcccacggcccuggcggagcgcugagaagacggucgaacungacuaucuagaggaaguaaaagucguancaagguuucnguaggugnnccugcggaaggaucauua ...<<<<<...[[[[>>>>>[[[.((((((.....{{.........[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[......{{....[[[[[.........<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<<<....>>>>>>...>>>>[[..(((((.....<<<<<<<<<<<<<..>>>>.......<......>..)))))......]]...<<<<.<<<<......>>>>>>>>.]].]]]...}}....]]].<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<<...>>>>..>>>......}}.......<<<<<<<<<.<<<....>>>..>>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..)))))).]]]............{{.......{{...[[[.[[....<<<.<<<<<<<..>>>>>>>.>>><<...<<<..<<<<<>>>>>.>>>.>>..<<<<<<.<.......<<...<.......>.<<<<.......>>>>...>>......>.>>>..>>>........{.[[.(((((((.....>>>>>>>>>.))))))).]].}....]]....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<<....>>>>>>>>>>>.>..>>>...<<..}}>>...>>.....>>>.....<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<........<<........>>..........<<<<<.<....<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<.......>>>>.>>>>.....>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.....>.>>>>>......>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<<<<<<<<<<<<<<.....>>>>>>>>>>>>.>.>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))((...(((((......(..((.....(((.(((..((....((....((..........))...)){))......(((.......(((.(....((....(((.....(({...((.....((.(((.....))).))......))......)).((((...((((((....))))))...))))((..(((((.....[[.[[[[[[.(((())))........(......)..)))))......)).(}((((.((((......)))))))))...)))...))..).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((....(((.}...)))..)))).)...)........(((((((((.(((....)))..)))))).)))....(.((..(...........)..))......)..((((([[....(.(.((.....((..]])).......)).)))))))..)))))...))..{......(.({{...(.(.((...(.(.((....(((..((((((()))))))..))).(....((..((((())))).))..)...(..(((.(........(..((.......)).((((...)..)))....).......).)))....)........(.((.(((((((.....]]]]]].]].))))))).)).)....))...(((..(...(...(((...((..((((((((...(..........)......))))))))..)).......((....))....)))..)...)...))..)).)...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..(.((((((.(((((....))))))))))).)..)))...((..}}))...))...}.))))).).(((......((.(....).))....)))...]]].]((((..(((((((..((..((.((..(((..(((((.......(........)...........(((((.(....(((((........(..(((........)))..)......)))))...((.(((...(.((((((....((..(((((....)))..(.((......)))...))..))....(((...(...((.(..(((((((((((((....).)))).)))).....))))..).))..).....(((((.....)))))........)))....))).))).....).))))).....).)))))...)).)))..))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....((((............)))).....)..)..)).)).....((((((((.......))))))))......))...))))))).)).))..(.(..((.(..((((.((..(.((((((((.(((..((((.((...((((((.((((.((((((.....)))))).))))..).)))))...)).))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>........ Mammalian quaternary complex of a translating 80S ribosome, NAC, MetAP1 and NatA/E; 18S rRNA 9f1d B5 3706 3.26 RF02543 39169182 0003735 0005840 9986 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcgguggggcgcgggaaauguggcguacggaagacccacuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagngngaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcgugguccggccgugccggcggucucggcggaucuuucccgcuccccguuccuggggguggggucggcgggggaccgccccccggccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggccccggcggggaagguggcccggggggacgccucgccgccgucguccgcggcggcggcgggcgcgaccccuccccggguguuacagccccgccccggcagcagcagcucgccgaaucccggggccgagggagcgagaccugugucgccgcgcucuccccccucgggggggccgggccgccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgugucacgccgucgggcucgggggaggccacggcgcgucgcgcgccggcgcgcgcgcgcgagcgagcgcacggggucggcggcgaugucggcuacccacccgacccnucuugnaacncggaccaaggagunuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcggcggcgccgucgucggccgaggugggaucccgaggcccuuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccnanagauggugancuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauagnggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcaaccccgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcngaacuggcgnugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgcuggcagucggcagagcgagaaagagaguggagccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaunuuggugguagunnnaaauauucaaacgagaacuuugaaggccgaaguggngaaggguuccaugngaacagnanuugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucagccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccnuauccgcagcaggucuncaaggugaacngccucuggnauguuggaacaanguagguaagggaagucggcaagcnggauccguaacuucnggauaaggauuggcucuaagggcugguagcagccgacuuagaacuggugcggaccaggngaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugccnagugcucugaaugucanagugangaaauucaaugaagcgcggnuaaacggcgggaguancuaugacucucuuaagguagcnaanugccucnucaucuaauuagugangcgcaugaanggaugancgagnuucccacugunccuaccuacuauccagcgaaaccacngncaagggaacgggcuuggnggaaucagcggngaaagaagacccuguugagcuugacncuagucuggcacggugaanagacacguuuuuucacugacccggugaggcgggggggcgagccccgaggggcucucgcuucuggcgccaagcgccgggccccgucgguccgggccggcggcggccgggcgcgacccgcuccggggacagugccagguggggaguuugacugnggcgguacaccugucaaacgguancgcaggnnuccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucagnacgaauacagaccgugaaagcggggccucacgauccuucugagcuuuuggguuuuaagcaggangugucagaaaaguuaccacagngauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuungaugucggnucuuccuaucauugugaagcagaauucaccaagcguungaunnuucacccacuaauagggaacgugngcugggnuuagancgucgugagacagguuaguuuuacccuacugaugnuguguuguugccaugguanuccugcucaguacgagaggaaccgcagnuncanacauuugguguaunugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgaaggagccucgguuggccucggauagccggucccccgcgggguccggugcggagagcccuucgucccgggaaauggggcgcggccggaaagggggccgcccucucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>>..<<<<<<<<<....<<<<<<<<.<<<....<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>>>>>>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<......>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<<....<<<<<<<.<<<<<.<.....<<<<<.<<<..<<<<<<<<<<<<<.<...>>>>>>>>..>>>>>>>>>>>>>>.>>>>>>>>>>...>>>.>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<.<<<<<<<<<<.<<<<...<<..<<<..<<<<<<<......<<<<<<<<<<....<<<<<<<<<<<<<<..>>>>>>>>>>>>>>........>>>>>>>>>>.......>>>>>>>..>>>.........>>>>>>...>>>>>>>>>>.....<<.....[[>>......<<<<<..<<<<<<<.>>>>>>>.<<<<<<.<<<<.<<<<<<<<<.<<<<<<<<<<<<<<.<<<<....>>>>.>>>>>>>>>>>.>>>.>>>>>>.>>>...>>>>..>>>>.>><<<<<.<<<<<<<..>>>>>>>>>>>>.....>>>>>......>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<<<<<<..>>>>>>>>>>>>..<<<<<...<<<..<<....((((.{{..>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<..........<<<.<<<<<<<<<...<<<....<<<....<<<..<<<<<<.<.....>.>>>>>>>>>....>>>..>.>>...>>>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<.......]]...........}}.))))..............>>>>>>>>>....>>>>>>.<.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<<<<<...>>>>>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<<<...<<<<<<<....>>>>>>>...<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<....>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<<<<..>>>>>>>>>>...<<<<<.....<<<<..<<.<<<<<<<..>>>>>>>>>..............<<<<<.<<<<.<<<<<<<<..>>>>>>>>..>>>>.>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>>.<<<....>>>.>>)))].....<<<<<<<..<<<..)))))).>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<]]].>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.....<<<<<<<..<<..<<<<....<<<........<<<<<..<<<<..>>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<........>>>>>>>>>>...>>>>..>>>..............>>>>..>>>>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<.<..<<<<<......>>>>>..>>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..(((((((((((.....)))))).))))....))))....(((((((((....((((((((.((.....((((((((..({((((......)))))....[[(...).(((....}]])))...).))))))).))))))))))...)))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....((((((((((.(..(((((((.(((((.((....(((((.(((..(((((((.((.((((())))).)).)..)))))))))))))))))))))))))...))))))))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((..(((((((......((((((((((....(((((((((((((....)))))))))))))........)))))))))).......)))))))..))).........))))))..))))))))))).....((.....{{))......((((((.(((((((.))))))).((((((.((((.(((((((((.((((((((((((((.((((....)))).))))))))))).))).)))))).)))...))))..)))).))(((((.(((((((()))))))))))))..[.)))))).....))).)))))...)))))...)))))))).<((((........))))((((((....(((((((((((((..(((..((((..........)))..)..)))...((....))...(((((.((((((..)))))).)))))..(((((...(((..((.(].[[[[.[[[)))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((........)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((..........(((.((((((((.....((.....((.....((...(((((.(.....).))))).)).....))...))......))))))...(((((((((.(......))))))))))....))))))))))))..))..((((..(.((.....)).)..))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.....A.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((.......}}.........].]].]]]].(...)........)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((..(((((((...((.....)).))))))....[[(((.((...(.....(((....)))...(.)....((.(((((((((...))))))))))).......)....))...(((((........)))))]]((((....(((((...((.((((....)))).))..((((....)))...(...((((((...((((((((((((((((((((((...{{{...)))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((....).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).))).))).....((......)).)))).((((.....))))..)))....(((......((((((..((..(....(.......(((((....(.[..).....)))))((.(((((((((((....)))))..)))))).))(...).......(((((((((.>.(...........)...(((((((....((((.....))))......))))))).].(.(.(((..((((((.(...(......((.(....).))......).)))))..)))))(.(.(.........).).)........((..........(((((.......)))))..)..)....).)....)).))))))).)..)))..))))))...)))))....)).[..((.((.....>].)).))....(((((..(((.((......((((.(((((...(((((.(((((((((.(((((.((((..)))).)))))...(((((.....((((..((.(((((((..)))))))))..............(((((.((((.((((((.(()).))))))..)))).)))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(..((.(..((....{..))...))).)(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}.....)))..)))))).......(....(..(((.(...((.......))...).)))....)....)........((((.((((((..(.(.(.(((......))).)...).).(((.(.....).))).....)))))..)...))).)......((((((....))).))).....))..))).))))).....(.((.(.(..(((..(.(((((......(....).....))))).)(((.....((((....((.(((((((}}}.)))))..)).))...))))....))).((((...((((.....a.......))))...))))..)))...).).)).).....(((((((..((..((((.(..(((.........((((..((((())))).))))........)))...(((..((((....((((.((((((........))))))))))...))))..)))...........)..))))..)))))))))(((((....(.......).......((.(((((((.((.....(.((.(..(((((......)))))..))).)....))....)))).))).))..))))).. Mammalian quaternary complex of a translating 80S ribosome, NAC, MetAP1 and NatA/E-HYPK; 28S rRNA 9f1d B7 119 3.26 RF00001 39169182 0003735 0005840 9986 ucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>... ((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))... Mammalian quaternary complex of a translating 80S ribosome, NAC, MetAP1 and NatA/E-HYPK; 5S rRNA 9f1d AT 76 3.26 39169182 9986 nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnncca ............................................................................ ............................................................................ Mammalian quaternary complex of a translating 80S ribosome, NAC, MetAP1 and NatA/E-HYPK; P-site tRNA 9f1d B8 156 3.26 RF00002,RF02540 39169182 0003735 0005840 9986 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauuncaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<<<<....>>>>.....<.<<<......>>.............>>>..>...>>>....<<....>><<<<<<<<<.....>>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]].............)))..)...)))....((....))(((((((((.....))))))))).................... Mammalian quaternary complex of a translating 80S ribosome, NAC, MetAP1 and NatA/E-HYPK; 5.8S rRNA 9f1d A2 1770 3.26 RF01960,RF02542,RF01959,RF00177 URS00023119C9_9986 39169182 0003735 0005840 9986 uaccugguugauccugccaguagcaunugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucnuuaaaucaguuauggunccuunggucgcucguacuuggauaacugugguanuucuagngcuaananaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucagaucaaaaccaacccggugccggcggcuuuggugacucuagauaaccucgggccgaucgcacgcccuccguggcggcgacgacccauucgaacgucngcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgaunccggaganggagccugagaaacggcuaccacauncaaggnaggcagcaggcgcgcnaauuacccacucccgacccggggangungugangaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaanuccuuuaacgaggnuccauuggagngcaagucuggugccagcagccgcggnaauuccagcuccaauancguauauuaaaguugcugcaguunaaaagcucguaguungaucuugggagcgggcggccgcccguccccgccucucggcgccccggggcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaaungaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagancgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacncaacacgggaaaccucacccggcccggacacggacagganugacagauugauagcucuuucucgauuccguggguggngnugcauggcnguucuuaguugguggagcgauuugucugguuaauuccgauaacgancgagacunuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuncuuanagggacaaguggcguucagccacccgagauugagcaauaacangucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgagnaauucccaguaagugcgggucauaagcuugcguugauunagucccugcccuuuguacacaccgnccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggucggcccacggcccuggcggagcgcugagaagacggucgaacungacuaucuagaggaaguaaaagucguancaagguuucnguaggugnnccugcggaaggaucauua ...<<<<<...[[[[>>>>>[[[.((((((.....{{.........[[[.[[[..<<....<<....<<..........>>...>>.>>......{{........[[[......{{....[[[[[.........<<.....<<.<<<.....>>>.>>......>>.........<<<<...<<<<<<....>>>>>>...>>>>[[..(((((.....<<<<<<<<<<<<<..>>>>.......<......>..)))))......]]...<<<<.<<<<......>>>>>>>>.]].]]]...}}....]]].<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<<...>>>>..>>>......}}.......<<<<<<<<<.<<<....>>>..>>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..)))))).]]]............{{.......{{...[[[.[[....<<<.<<<<<<<..>>>>>>>.>>><<...<<<..<<<<<>>>>>.>>>.>>..<<<<<<.<.......<<...<.......>.<<<<.......>>>>...>>......>.>>>..>>>........{.[[.(((((((.....>>>>>>>>>.))))))).]].}....]]....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<<....>>>>>>>>>>>.>..>>>...<<..}}>>...>>.....>>>.....<<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<........<<........>>..........<<<<<.<....<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<.......>>>>.>>>>.....>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.....>.>>>>>......>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<<<<<<<<<<<<<<.....>>>>>>>>>>>>.>.>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))((...(((((......(..((.....(((.(((..((....((....((..........))...)){))......(((.......(((.(....((....(((.....(({...((.....((.(((.....))).))......))......)).((((...((((((....))))))...))))((..(((((.....[[.[[[[[[.(((())))........(......)..)))))......)).(}((((..(((......))).)))))...)))...))..).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((....(((.}...)))..)))).)...)........(((((((((.(((....)))..)))))).)))....(.((..(...........)..))......)..((((([[....(.(.((.....((..]])).......)).)))))))..)))))...))..{......(.({{...(.(.((...(.(..(....(((..((((((()))))))..))).(....((..(((.().))).))..)...(..(((.(........(..((.......)).((((...)..)))....).......).)))....)........(.((.(((((((.....]]]]]].]].))))))).)).)....)....(((..(...(...(((...((..((((((((...(..........)......))))))))..)).......((....))....)))..)...)...))..)).)...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..(.((((((.(((((....))))))))))).)..)))...((..}}))...))...}.))))).).(((......((.(....).))....)))...]]].]((((..(((((((..((..((.((..(((..(((((.......(........)...........(((((.(....(((((........(..(((........)))..)......)))))...((.(((...(.((((((.(..((..(((((....)))..(.((......)))...))..))....(((...(...((.(..(((((((((((((....).)))).)))).....))))..).))..).....(((((.....)))))........))).)..))).))).....).))))).....).)))))...)).)))..))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....((((............)))).....)..)..)).)).....((((((((.......))))))))......))...))))))).)).))..(.(..((.(..((((.((..(.((((((((.(((..((((.((...(((((((((.(.((((((.....)))))).).))).).)))))...)).))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>........ Mammalian quaternary complex of a translating 80S ribosome, NAC, MetAP1 and NatA/E-HYPK; 18S rRNA 9f2r R 15 1.959 11320 accucugcuucugcu ............... ............... Influenza A/H17N10 polymerase with bound promoter and 3' end of template in active site; 3' end of the promoter vRNA 9f2r V 16 1.959 11320 aguaguaacaagaggg .<<....>>....... .((....))....... Influenza A/H17N10 polymerase with bound promoter and 3' end of template in active site; 5' end of the promoter vRNA 9f37 R 15 1.905 11320 accucugcuucugcu ............... ............... Replication-like initiation state of influenza polymerase with GTP and CTP at respectively the -1 and +1 positions (strain A/little yellow-shouldered bat/Guatemala/060/2010/H17N10); 3' end of the vRNA promoter 9f37 V 16 1.905 11320 aguaguaacaagaggg .<<....>>....... .((....))....... Replication-like initiation state of influenza polymerase with GTP and CTP at respectively the -1 and +1 positions (strain A/little yellow-shouldered bat/Guatemala/060/2010/H17N10); 5' end of the vRNA promoter 9f9s CM 41 2.9 39566505,31588918 4932 uuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuaaacgacgaa ......................................... ......................................... Yeast SDD1 Disome with Mbf1; mRNA 9f9s CP 76 2.9 RF00005 URS000080E1EA_4932 39566505,31588918 0030533 0006412 4932 uuccucguggcccaauggucacggcgucuggcuicgaaccagaagauuccagguucaaguccuggcggggaagcca <<<<<<<..<<<..........>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..(((.....[....))).(((((.......))))).....(((((..]....)))))))))))).... Yeast SDD1 Disome with Mbf1; tRNA P-site, stalled 9f9s L1 3116 2.9 RF02540,RF02541,RF02543 39566505,31588918 0003735 0005840 4932 uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaagcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagcggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaauuuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacaggacgucauagagggugagaaucccguguggcgaggagugcgguucuuuguaaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggugguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaaguacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaaguacgugaaauuguugaaagggaagggcauuugaucagaggccagcaucaguuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguauuauagccugugggaauacugccagcugggacugaggacugcgacguaagucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcguaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgaccgauccugaugucuucggauggauuugaguaagagcauagcuguugggacccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucugguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaugauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaauauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaagagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaaccgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaagguguuaguucaucuagacagccggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaauggauggcgcucaagcguguuaccuauacucuaccgucaggguugauaugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaaggucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagcaguuggacguggguuagucgauccuaagagauggggaagcuccguuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguuaagauuccggaaccuggauauggauucuucacgguaacguaacugaauguggagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaauugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaacagccucuaguugauagaauaauguagauaagggaagucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucggguacgaucaacuuagaacugguacggacaaggggaaucugacugucuaauuaaaacauagcauugcgauggucagaaagugauguugacgcaaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacucuaguuugacauuguguacuuauucaaugaagcggagcuacguucuagcauucaaggucccauucggggcugauccggguugaagacauugucagguggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcucauggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugauuuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauuucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagauguacaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<......<<.....>>.....>>>>>..<<<...........<<.<<<<<<...>>>>>>.>>.............<<<<<<.<<<<<<<<<<<<<<<<<<<<<<....<<<<......>>>>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>....>>>>>>>>>>>........<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<<....>>>>..................................<<<<<.<<<<<....<<<<<<<.<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<......>>>>>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>>>.....>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<....<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>..>>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....>>.........<<......>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>>><<<<<<<<<.........>>>>>>>>>....>>>>>><.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>........<<<.<.<.....>..>.>>>....>>....>>...<<<<<........>>>>>))<<<<.<<<<<.<.....<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..[[[..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>..........>.>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<<<<....<....>.....>>>>><<.<<<<<<<<<<<....>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.....<<.....<<<<....>>>>.....>>..>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<..<<..>>...<<<<<.....<<<<...................<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))......<<<<<<<..<<<<.))))))>>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>..>>.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>....<<<<<<<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<....<<<<<<<<<<]]].>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>.>>>>....>>>>>>>>.......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<.............>.....<<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>...>>>....>>>>.>>>>>..>>>>>.. ........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((((((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))))))....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.(((((....(((((((((((((((((((((((.......(((((((......((((........)))).......))))))).....))))).))))))))))........(((....)))....)))))))).....))))).))))).[((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)[)))...(((..((.((.......<)))).)))....))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((((((((((....((.(((((((.....(((....(((..(.((((....(((((.....)))))..)))).)..)))..)).).....)))))...((((.((((.(......))))).)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{..((((.(((...((.........))...))).........((......))...))))....)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....)))........((.((.(.....)...))))....))....))...(((((........)))))]]((((..(((.(((...((((....)))...(.<.((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)(((((((......))))))))))).).))))))).))))(...)....))))))...))....)))...))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.{..).....)))))((.(((((((((((....)))))..)))))).))(...).......(((((((((.].((.........))...(((((((....((((.....))))......))))))).}.(((.(((..((((((.(...((.....((((....)))).....)).)))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.((......((((.((((((..(((((.((((((((..((()))....((((.....((((..()...........>...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....)))))))...(((..((((....{..))))..))).(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..>.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..)..)))))..)))))...)))....)))).)))))).))))).. Yeast SDD1 Disome with Mbf1; Saccharomyces cerevisiae S288C 25S ribosomal RNA (RDN25-1) 9f9s L2 158 2.9 RF00002 39566505,31588918 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Yeast SDD1 Disome with Mbf1; Saccharomyces cerevisiae S288C 5.8S ribosomal RNA 9f9s L3 121 2.9 RF00001 39566505,31588918 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<<............>>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Yeast SDD1 Disome with Mbf1; Saccharomyces cerevisiae S288C 5S ribosomal RNA 9f9s S1 1771 2.9 RF01960,RF02542,RF01959,RF00177 39566505,31588918 0003735 0005840 4932 uaucugguugauccugccaguagucauaugcuugucucaaagauuaagccaugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucauuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacugugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacggguaacggggaauaaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguagugacaauaaauaacgauacagggcccauucgggucuuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccggucggauuuccaacggggccuuuccuucuggcuaaccuugagcuuggcgaaccaggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguugguuucuaggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggggaaacucaccagguccagacacaauaaggauugacagauugagagcucuuucuugauuuugugggugguggugcauggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaagccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauu ...<<<<<.{.((((>>>>><<<<.<<<<<<...<.<...<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<..<<..<<....<<<..................<<....<<.<<<.....>>>.>>.....>>.........<<<<<..<<....>>..>>>>><.<.<<<<<<......(((.{((.<<<....>>>....<<......>>>>>>>>.>...>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>..>>>..>....>.>.....<<<<<<<<<<<<<....>>>>>>>>>>.>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>>.........<<<[[.....<.<<...<<<.<<....<<<<<<.<<<<..............>>>>.>>>>>>.....<<<<<....................>>>>>....<<<<<.<<.......<<...<.......>..<<<<...>>>>....>>......>>.>>..>>>.........<<<..<<<<<<<<.....)).}))).>>>>>>>>.>>>.....>>....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..]]>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>..)))).}<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>......<....<<<<<<..........>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<<<.<<<<.<<<<....>>>>.>>>>.>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>........ ...((((..[.[[[..))))((((.((((((...(.(...((.....(((.(((..((....((....((..........))...)){))......(((.......(((..((..((....(((..................((....((.(((.....))).)).....)).........(((((..((....))..)))))(.(.((((((......[[[.[[[.(.(....).).....(......).)))))).)...).(.((((...(((..).))..)))))...)))...))))..))).(((....(((....((((((((.......)))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.}...))).))))).)....).).....(((((((.(.(((....))).).)))).)))....(.(((.(...........)).))......)..((((([[....(.((((.....((..]])).......))))))))))..))))))))))..{......((({{...(.(.((...(((.((....((((((.(((................))).))))))....(.((((....................)))).)...(((((.((.......((..((.......)).(((.....)))....))......)).))..))).........(....(.((.((......]].]]]]..)).)).)...).....))...(((..((.((...((((..(((.((((((.....((........))........)))))).))).......((....))...))))..)).))...))..))))...)).)....((((((....(...((((.........))))...).))))))......<...(((.((.(((..((((((((.(((........)))))))))))..)))...((..}}))...))...}.))))))).(((......((((....))))....)))...]]].].((((.(((((((..((..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((((.((..((((..(((((.((((((....))))))...)))))..)))).))..(.((((((.....))))))....)..)))))....))).))).....).))))).....).)))))...)).)))).))).(...(((((((......((.....((..((((....))))..))....)).......)))))))......(....((((((..........))))))....)..)..))))).....(.((((((.......)))))).)......))...)))))))))).)...(.(..((.(..((((.((..(.((((((((.(((..(.((..(...((((((..((((.((((....)))).))))..))))))...)..)).)..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))>....... Yeast SDD1 Disome with Mbf1; Saccharomyces cerevisiae S288C 18S ribosomal RNA (RDN18-1) 9f9s R1 1758 2.9 RF01960,RF02542,RF01959,RF00177 39566505,31588918 0003735 0005840 4932 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...<<<<<.{.[[[[>>>>><<<<.<<<<<<...<.<...<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<..<<..<<....<<<..................<.....<<.<<.......>>.>>......>.........<<<<<..<<....>>..>>>>><...<<<<<<......((((((..<<<....>>>..............>>>>>>.....>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>....<<<..........>>>....<.<<<..>>>.>...>>>>>>.........<<<....<<<.....>>>..>>>..>....>.>.....<<<.<<<<<<<<<....>>>>>>>>>..>>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>>.........<<<[[.....<.<<...<<<.<<.....<<<<<.<<<<<....<<>>....>>>>>.>>>>>.......<<<<...........<<.....>>...........>>>>.....<<<<<.<<.......<<...<.......>..<<<.....>>>....>>......>>.>>..>>>.........<<<..<<<<<<<<......)))))).>>>>>>>>.>>>.....>>....<<<<<<.<<...<<<<...<..<<<<<<.<...<<<......>>>......>.>>>>>>..>........<<....>>...>>>>...>>>>>.>>>...>>>...>>.>......<<<.........<<<<.<.....>.>>>>.....>>.>............<<<.<<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..]]>>...>>.....>>>.>>>.<<<......<<<......>>>....>>>..]]]].}<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<........<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>......<....<<<<<<..........>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<.......<.<<..<...<<<<<...>>>>>...>..>>.>.......>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>......... 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Yeast SDD1 Disome with Mbf1; Saccharomyces cerevisiae S288C 18S ribosomal RNA (RDN18-1) 9f9s M1 3190 2.9 RF02540,RF02541,RF02543 URS000061F377_4932 39566505,31588918 0003735 0005840 4932 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........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((.........(((.((((((...)))))).))....)........((((((.(((((..((((((((((((((...({((((......)))))[[(...).(((....}]])))....))))))))..))))).).....)))))))))))...)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................(((((.((((((...(((((((((((((((((((((((.......(((((((......((((.(....).)))).......))))))).....))))).))))))))))........(((....)))....))))))))....)))))).))))).<((((........))))((((((..(.((((((.((((((..(((...(((.......)))...)))...((....)).......(((((..(((((....)))))...))))).((((((((....(....)....))).))).))....)))))).))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))..).))))))))).(.((.......))...)..))))))......).))).((((((....(.(((....))).)((((((((((....((.(((((((.....(((....(((..(.((((...((((((.....)))))).)))).)..)))..)).).....)))))...((((..(((.(......))))..)))).....))))..)))))))).))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.((((((......(..........(((.((((((((((.....{.(((((.(((...((.........))...))).....(...((......)).).)))))...)))))))))))))..........]]].)....))))))))))...)))))))(((((((((.........)))))))))....))))))(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......))))))((((.....((((..((...(((((....((.....))..)))))....[[(((.((...((....(((....))).........(.(.............).)....))....))...(((((........)))))]]((((..(((((((...((((....)))...(.[[((((((...((((.((((((((((((((((((...{{..))))))(...(((((....(((((.....(((.....))).....))))).....)))))....)((((((((....)))))))))))).).))))))).))))(...)....))))))...))....))))..))).)))).)))..)).....((......)).)))).((((.....))))..))))..((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.((((((((((()))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.....((.....((((....)))).....))..))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).[..(((((.....>].)))))....(((((..(((.((......((((.((((((..(((((.((((((((..(((((((((((.....((............(..........................)..))....).))))))))))....((((.....((((..((((()))))..........]]...((((((....))))))..))))..))))......))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((][.[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].].....((((((..((((.]]]]]]))))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(((((((......))))))..).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a.))..))).)))))....((((((((..((((.(.(((((......(....).....))))).)(((((...((((....((((((((((}}..)))))..)))))...))))..))))).((((...((((.....}.......))))...)))).))))....)))))))).......((((((.(((.((....((.(........(((((((..).)))))).....))).......((((((...(((((.(..(((......)))..).))))).)))))).............)).))).))))))..(((((.(..(.......)..)...(.(((((((((.(((....((((.(..((((((..))))))..)))))...)))....)))).)))))).))))).. Yeast SDD1 Disome with Mbf1; Saccharomyces cerevisiae S288C 18S ribosomal RNA (RDN18-1) with modifications 9f9s M3 121 2.9 RF00001 39566505,31588918 0003735 0005840 4932 gguugcggccauaucuaccagaaagcaccguuucccguccgaucaacuguaguuaagcugguaagagccugaccgaguaguguagugggugaccauacgcgaaacucaggugcugcaaucu <<<<<<<<<....<<<<<<<<.....<<.<<<............>>>....>>....>>>>>>.>><<<<<<.......<<<<<..<<....>>.>>>>>.....>>>>>>>>>>>>>>>. (((((((((....((((((((.....((((((...(....)...))).)..))....)))))).))((((((.......(((((..((....)).))))).....))))))))))))))). Yeast SDD1 Disome with Mbf1; Saccharomyces cerevisiae S288C 5S ribosomal RNA 9f9s M2 158 2.9 RF00002 39566505,31588918 0003735 0005840 4932 aaacuuucaacaacggaucucuugguucucgcaucgaugaagaacgcagcgaaaugcgauacguaaugugaauugcagaauuccgugaaucaucgaaucuuugaacgcacauugcgccccuugguauuccagggggcaugccuguuugagcgucauuu .........................................<<<<<<.<<.....>>>.....(.<<<......>>..............>>>..)...>>>....<<.....>><<<<<<<<<....>>>>>>>>>..................... .........................................((((((.[[.....))).....(.((((.....]]............).)))..)...)))....((.....))(((((((((....)))))))))..................... Yeast SDD1 Disome with Mbf1; Saccharomyces cerevisiae S288C 5.8S ribosomal RNA 9f9s DQ 77 2.9 RF00005 39566505,31588918 0030533 4932 cgcgggguggagcagcccgguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(.((...].....)).)))))))..... Yeast SDD1 Disome with Mbf1; tRNA 9f9s DP 76 2.9 RF00005 39566505,31588918 0030533 4932 gcggauuuagcucaguugggagagcgccagacugaanaucuggagguccuguguucgauccacagaauucgcacca <<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((........)))).(((((.......))))).....(((((.......)))))))))))).... Yeast SDD1 Disome with Mbf1; tRNA 9fbv b 119 2.4 RF00001 38826346 0003735 0005840 679895 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>> ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))) 70S Escherichia coli ribosome with P-site initiatior tRNA.; 5S ribosomal RNA 9fbv a 2753 2.4 RF02541 38826346 0003735 0005840 679895 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagcgucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcgcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<..>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<..>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<..<<....>>...>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<..>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((((((.....))))).))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(())...)))..))))).))...........]]].)...))))))))))...)))))))((((((((()))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((())))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). 70S Escherichia coli ribosome with P-site initiatior tRNA.; 23S ribosomal RNA 9fbv A 1519 2.4 RF00177,RF01959,RF02542,RF01960 URS000081169C_679895 38826346 0003735 0005840 679895 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugccggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngaaccugcgguuggauca .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<......>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<.>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<..>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<......>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((........))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((.)))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((((())))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))...(......)..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... 70S Escherichia coli ribosome with P-site initiatior tRNA.; 16S ribosomal RNA 9fbv Z 73 2.4 RF00005 38826346 0030533 679895 gcgggguggagcaggguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca <<<<<<..<<<<......>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... ((((((..((((...[..)))).(((((.......))))).....(((((..]....)))))))))))..... 70S Escherichia coli ribosome with P-site initiatior tRNA.; fMet-tRNA 9fhl 2 1430 2.5 RF01959,RF00177,RF01960,RF02542 39753558 0003735 0005840 273057 aauccgguugauccngccggacccgaccgcuaucgggguggggcuaagccangggagucguacgcucccgggcaagggagcguggcggacggcugaguaacacguggcuaacnuacccugaggagggagauaaccccgggaaacuggggauaaucucccauaggcgaggaguccuggaacgguuccucgcugaaaggcucaugggcuauuccccgcucaugagcgccucaggauggggcugcggcncaucagguaguuggggggguaagggccccccaagccuauaacggguaggggccgugagagcgggagnccccaguugggcacugagacaagngcccaggcccuacggggcgcaccaggcgcgaaacguccccaaugcgcggaagcgugagggcnccaccccgagugcucccguaagggagcuuuuccccgcucuacaaaggcgggggaauaagcggggggcaagucuggugucagncgccgcgguaaunccagccccgcgaguggungggacucuuacugggccuaaagcgcncguagccngcccgacaagucacuccuuaaagaccccggcucaaccgggggaaugggggugauacugucgggcuagggggcgggagaggccagcgguacucccggaguaggggcgaaauccucagaucucgggangaccaccaguggcgaaagcggcuggcuagaacgcgccngacggugaggggcgaaagccggggcagcaaaagggauuagauaccccuguagucccggcuguaaacaaugcaggcuaggugucacaugggcuuagagcccauguggugccgcagggaagccguuaagccugcngccuggggaguacggucgcaanacugaaacuuaaaggaauuggcgggggagcaccacaaggnguggaaccugcggcucaauungagncaacgccuggaaucuuacuaggggagaccgcaggaugacggccaggcuaacgaccuugccugacucgcggagaggaggugcauggccnucgccagcucgugnugugaaauguccuguuaagucaggcaannagcgagacccccaccacuaguugguauccuggucuccgggccgggaccacacuagugggacugccggcguaagccggaggagggagggggccacggcaggucagcaugccccgaaaccccugggccgcacgcngguuacaauggcagggacagcgggauuccgaccccgaaaggggaagguaaucccuuaaacccugccgcaguugggaucgagggcugaaacucgcccucgugaacgaggaaucccuaguaaccgcagaucaacaaucugcggugaauacgncccugcuccuugcacacaccgncngucgcuccagggagaagucguancaagguagnnguaggggnannugcggcuggaucaccucc ...<<<<<.[.((((>>>>>.<<<<<<<<<..<<<<<<.<<......<<<.<<<..<<<..<<<<<<<<(((...>>>>>>>>>>>......<<........<<<<<<<..<<...<<<<<<<.<<<<<...<<<<<<......>>>>>.>...>>>>>...<<<<<<<<<.<<......>>>>>>>>>>>.....<<<<<<<<<<.....)))>>>>>>>>>>.>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<............>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<<<....>>>>>>...<<<<<<<<.......>>>>>>>>.....<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<.....<<<<<<<<<..<<<<<<<.<..<<<......>>>.....>.>>>>>>>..>>.......<<....>>.>>>>>>>....>>>.>>>...>>>...>>>>...<<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>>.........<<<<<<..<<<<<<<<<<<<<<.....>>>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<.<<<<<<..<<<<<<<<........<<........>>..........<<<<<<<...<<<<<<......<<<.<<<.......>>>.>>>...>>.>>>>...<<.<<<..<<<<<<<<.....<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>....<<<<<.<<<<<<...<<..<<<<<<<......>>>>>>>>>....>>>>>>.....<<<<<....>>>>>........>>>>>.....>>.>>>...>>>>>>>>....>>>>>>>......>>>>>>>>.....<<<<<<<.....<<<...<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<..>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>........... ...((((..[.[[[..)))).(((((((((..((((((.(((.....(((.(((..(((..(((((((([[[...)))))))))))......(((.......(((((((..((...(((((((.(((((....((((((....)))))).....)))))...((((((((..((......)).)))))))).....((((((((((.....]]])))))))))).)))))))..))))))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((((....))))))....(((((((.......)))))))......((((([[....(.((((.....((..]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((.....((((((((((.(((((((....((........)).......))))))).))).......((....)).)))))))....))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((((.....))))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..((((((((((......((........))..........(.(((((...((((((......(((.(((.......))).)))...)).))))...((.(((...((((((((....(((((((((....)))..((((......))))..))))))....(((((.(((((((..((..(((.((((....)))).)))))...)))))))..(..(((((....))))).....)..)))))....))).)))...)).)))))....))))).)...)).)))))))).(...(((((((.....(((...((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(.((((..))))..).))...)..)..(((((((((....)))))))))}.......... High-resolution cryo-EM structure of Saccharolobus solfataricus 30S ribosomal subunit bound to mRNA and initiator tRNA; rRNA 16S Sso 9fhl s 10 2.5 39753558 273057 ugaggaugaa .......... .......... High-resolution cryo-EM structure of Saccharolobus solfataricus 30S ribosomal subunit bound to mRNA and initiator tRNA; mRNA_Map 9fhl 4 17 2.5 39753558 273057 ucgggnucauaacccga <<<<<.......>>>>> (((((.......))))) High-resolution cryo-EM structure of Saccharolobus solfataricus 30S ribosomal subunit bound to mRNA and initiator tRNA; Initiator tRNA Met 9fi8 bN 58 3.6 39690155 5811 uagacuagcguuggagcacauuguuucauucgauaguccacgcucaaucuuaccauac .......................................................... .......................................................... SSU(head) structure derived from the SSU sample of the mitoribosome from T. gondii.; SSUB-SSU 9fi8 hB 56 3.6 39690155 5811 ggaagcuggaagacggaaucguuauuaagcgccagguaguccuggacacugaaucc ...........................<<.<...............>.>>...... ...........................((.(...............).))...... SSU(head) structure derived from the SSU sample of the mitoribosome from T. gondii.; SSUD 9fi8 hD 15 3.6 39690155 5811 uuuuuuuuuuuuuuu ............... ............... SSU(head) structure derived from the SSU sample of the mitoribosome from T. gondii.; ulr22 9fi8 hG 68 3.6 39690155 5811 uucaccuagccaacacgauccgguuguuugggaacaauucccuucuagaaggguaaucuaugugcuac .................................................................... .......................................((.(......)))................ SSU(head) structure derived from the SSU sample of the mitoribosome from T. gondii.; RNA9-SSU 9fi8 hL 33 3.6 39690155 5811 cguagcuguagaugaaugcuaauuauagaguau ................................. ................................. SSU(head) structure derived from the SSU sample of the mitoribosome from T. gondii.; RNA5-SSU 9fi8 hR 27 3.6 39690155 5811 uauuguguuagcaugguuucgagaaca ........................... ........................... SSU(head) structure derived from the SSU sample of the mitoribosome from T. gondii.; RNA19-SSU 9fia b2 30 3.29 39690155 5811 agucuuaaacacaccgcucgucacguaaca .............................. .............................. SSU(body) structure derived from the SSU sample of the mitoribosome from T. gondii.; SSUE 9fia b4 27 3.29 39690155 5811 agggauguuuagccgggaaguuagcgu ........................... ........................... SSU(body) structure derived from the SSU sample of the mitoribosome from T. gondii.; RNA13 9fia bA 27 3.29 39690155 5811 aguucuauuguguuagcaugguuucga ........................... ........................... SSU(body) structure derived from the SSU sample of the mitoribosome from T. gondii.; RNA19 9fia bD 25 3.29 39690155 5811 gcgagaagggaaguguguuucaaag ......................... ......................... SSU(body) structure derived from the SSU sample of the mitoribosome from T. gondii.; RNA15 9fia bE 92 3.29 39690155 5811 uaauacaggguugaacuguggguuaguuucaaugcccaaggcagagcacuggauuggauacccagggaacugugcucccauuaauaagaauc ................................................<...............>........................... ................................................(...............)........................... SSU(body) structure derived from the SSU sample of the mitoribosome from T. gondii.; RNA8 9fia bJ 58 3.29 39690155 5811 gauuaagcugcauuacguuuaaacuuuacacuggauacguuuuaauguuaacuuacua .......................<........<......>......>........... .......................................................... SSU(body) structure derived from the SSU sample of the mitoribosome from T. gondii.; RNA33 9fia bK 66 3.29 39690155 5811 acaguuaccguagcuguagaugaaugcuaauuauagaguauaucuccuaugacacugcauaacaua .<<<<.......>>>>.................................................. .(((.........))).................................................. SSU(body) structure derived from the SSU sample of the mitoribosome from T. gondii.; RNA5 9fia bL 48 3.29 39690155 5811 uuuuaugaucccaggcugguuuaauaagucaaaguuuagccagagucg ................<.....................>......... ................(.....................)......... SSU(body) structure derived from the SSU sample of the mitoribosome from T. gondii.; RNA17 9fia bN 50 3.29 39690155 5811 ucuuugccuggagguucguacaguuguagguaaaagguauguuagagacu .........<....................>................... .................................................. SSU(body) structure derived from the SSU sample of the mitoribosome from T. gondii.; SSUB 9fia bO 115 3.29 39690155 5811 agaggcuugauaguacuaccguaaguacauaauauacagucccagcaguagcgguuaaacuauagaagagucgaguauuauccauacauaccaggcguaaaaagcguucauccau ...<<<<..............................<<.....<<....>>.......>>.......>>>>........................................... ...((((..............................((.....((....)).......)).......))))........................................... SSU(body) structure derived from the SSU sample of the mitoribosome from T. gondii.; SSUA 9fia bP 15 3.29 39690155 5811 uuuuuuuuuuuuuuu ............... ............... SSU(body) structure derived from the SSU sample of the mitoribosome from T. gondii.; ulr16 9fia bQ 14 3.29 39690155 5811 uuuuuuuuuuuuuu .............. .............. SSU(body) structure derived from the SSU sample of the mitoribosome from T. gondii.; ulr17 9fia bR 19 3.29 39690155 5811 agaucaucgaauauaacgg ................... ................... SSU(body) structure derived from the SSU sample of the mitoribosome from T. gondii.; RNA30 9fia bS 31 3.29 39690155 5811 uuuuuuuuuuuuuuuuuuuuuuuuuuuuuuu ............................... ............................... SSU(body) structure derived from the SSU sample of the mitoribosome from T. gondii.; url18 9fia bT 52 3.29 RF02542 39690155 0003735 0005840 5811 gguacgaagucgaaacaagguaguugauggugaaccaguggcugaacaaaaa .....................<<<<<.<<<....>>>.>>>>>......... .....................((.((.(((....))).)).))......... SSU(body) structure derived from the SSU sample of the mitoribosome from T. gondii.; SSUF 9fmd 2 120 3.3 RF00004 URS0000E60B75_9606 38925148,30705154 0045131 0000348 0005686 9606 aucgcuucucggccuuuuggcuaagaucaaguguaguaucuguucuuaucaguuuaauauauauuaaaagauuuuuggaacugcaucgaccugguauugcaguaccuccaggaacggugc .....................................................<<<<<<..>>>>>>...............<<<<<<.<<<<<.............>>>>>..>>>>>> .....................................................((((((()))))))...............((((((.(((((.............)))))..)))))) Integrative model of the human post-catalytic spliceosome (P-complex); U2 snRNA 9fmd 5 92 3.3 RF00020 38925148,30705154 0000244,0000353 0005682,0046540 9606 guuucucuucagaucgcauaaaucuuucgccuuuuacuaaagauuuccguggagaggaacaccaauuuuuugagccuugccuuggcaaggcu <<<<<<<<<<<........<<<<<<<<...........>>>>>>>>...>>>>>>>>>>>............<<<<<<<<....>>>>>>>> (((((((((((...((...((((((((.(.......).)))))))).))))))))))))).............(((((((....))))))). Integrative model of the human post-catalytic spliceosome (P-complex); U5 snRNA 9fmd 6 97 3.3 RF00026 38925148,30705154 0030621 0000244,0000353 0005688,0046540 9606 gugcucgcuucggcagcacauauacuaaaauuggaacgauacagagaagauuagcauggccccugcgcaaggaugacacgcaaauucgugaagcguu <<<<<.<<....>>>>>>>.....................................<<...<<<.....>>>....>>................... (((((.((....))))))).....................................((..((((.....)))..).))................... Integrative model of the human post-catalytic spliceosome (P-complex); U6 snRNA 9fmd EX 14 3.3 38925148,30705154 10515 ggccuccgaacgcu .............. .............. Integrative model of the human post-catalytic spliceosome (P-complex); Exon 9fmd IN 42 3.3 38925148,30705154 10515 guaagagccuagcauguagaaugaugucauacuuauccucag .......................................... .......................................... Integrative model of the human post-catalytic spliceosome (P-complex); INTRON 9fra 2 1496 2.8 RF01959,RF00177,RF01960,RF02542 39753558 0003735 0005840 273057 aauccgguugauccngccggacccgaccgcuaucgggguggggcuaagccangggagucguacgcucccgggcaagggagcguggcggacggcugaguaacacguggcuaacnuacccugaggagggagauaaccccgggaaacuggggauaaucucccauaggcgaggaguccuggaacgguuccucgcugaaaggcucaugggcuauuccccgcucaugagcgccucaggauggggcugcggcncaucagguaguuggggggguaagggccccccaagccuauaacggguaggggccgugagagcgggagnccccaguugggcacugagacaagngcccaggcccuacggggcgcaccaggcgcgaaacguccccaaugcgcggaagcgugagggcnccaccccgagugcucccguaagggagcuuuuccccgcucuacaaaggcgggggaauaagcggggggcaagucuggugucagncgccgcgguaaunccagccccgcgaguggungggacucuuacugggccuaaagcgcncguagccngcccgacaagucacuccuuaaagaccccggcucaaccgggggaaugggggugauacugucgggcuagggggcgggagaggccagcgguacucccggaguaggggcgaaauccucagaucucgggangaccaccaguggcgaaagcggcuggcuagaacgcgccngacggugaggggcgaaagccggggcagcaaaagggauuagauaccccuguagucccggcuguaaacaaugcaggcuaggugucacaugggcuuagagcccauguggugccgcagggaagccguuaagccugccgccuggggaguacggucgcaanacugaaacuuaaaggaauuggcgggggagcaccacaaggnguggaaccugcggcucaauungagncaacgccuggaaucuuacuaggggagaccgcaggaugacggccaggcuaacgaccuugccugacucgcggagaggaggugcauggccnucgccagcucgugnugugaaauguccuguuaagucaggcaannagcgagacccccaccacuaguugguauccuggucuccgggccgggaccacacuagugggacugccggcguaagccggaggagggagggggccacggcaggucagcaugccccgaaaccccugggccgcacgcngguuacaauggcagggacagcgggauuccgaccccgaaaggggaagguaaucccuuaaacccugccgcaguugggaucgagggcugaaacucgcccucgugaacgaggaaucccuaguaaccgcagaucaacaaucugcggugaauacgncccugcuccuugcacacaccgncngucgcuccacccgaguaggagaggggugaggccccuugccuuuggguggggggucgagcuucucuccugcaaggggggagaagucguancaagguagnnguaggggnannugcggcuggaucaccucc ..<<<<<<.[.((((>>>>>><<<<<<<<<..<<<<<<.<<......<<<.<<<..<<<..<<<<<<<<(((...>>>>>>>>>>>......<<........<<<<<<<..<<...<<<<<<<.<<<<<...<<<<<<<....>>>>>>.>...>>>>>...<<<<<<<<<.<<......>>>>>>>>>>>.....<<<<<<<<<<.....)))>>>>>>>>>>.>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<............>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<<<....>>>>>>...<<<<<<<<.......>>>>>>>>.....<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<.....<<<<<<<<<..<<<<<<<.<..<<<......>>>.....>.>>>>>>>..>>.......<<....>>.>>>>>>>....>>>.>>>...>>>...>>>>...<<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>>.........<<<<<<..<<<<<<<<<<<<<<.....>>>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<.<<<<<<..<<<<<<<<<.......<<........>>..........<<<<<<<...<<<<<<......<<<.<<<.......>>>.>>>...>>.>>>>...<<.<<<..<<<<<<<<.....<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>....<<<<<.<<<<<<...<<..<<<<<<<......>>>>>>>>>....>>>>>>.....<<<<<....>>>>>........>>>>>.....>>.>>>...>>>>>>>>....>>>>>>>....>.>>>>>>>>.....<<<<<<<.....<<<...<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<...<<<<<<<<<<<<..<<<<<<<<<<<....>>>>>>>>>>>..>>>>>>>>>>>>...>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>........... ...((((..[.[[[..)))).(((((((((..((((((.(((.....(((.(((..(((..(((((((([[[...)))))))))))......(((.......(((((((..((...(((((((.(((((....((((((....)))))).....)))))...((((((((..((......)).)))))))).....((((((((((.....]]])))))))))).)))))))..))))))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((((....))))))..(.(((((((.......)))))))....).((((([[....(.((((.....((..]])).......))))))))))..)))))))))..........((([[.....((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((.....((((((((((.(((((((....((........)).......))))))).))).......((....)).)))))))....))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((((.....))))))))))))))...((..]])).....)))))).))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..((((((((((......((........))..........(.(((((...((((((......(((.(((.......))).)))...)).))))...((.(((...((((((((....(((((((((....)))..((((......))))..))))))....(((((.(((((((..((..(((.((((....)))).)))))...)))))))..(..(((((....))))).....)..)))))....))).)))...)).)))))....))))).)...)).)))))))).(...(((((((.....(((...((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(.((((.(((..(.(((((((..((..((((((((.((....)).))))))))..))..))))))).)..))).))))..).))...)..)..(((((((((....)))))))))}.......... Cryo-EM structure of Saccharolobus solfataricus 30S initiation complex bound to Ss-MAP leaderless mRNA; rRNA 16S 9fra 5 14 2.8 39753558 273057 nugacugaggauga .............. .............. Cryo-EM structure of Saccharolobus solfataricus 30S initiation complex bound to Ss-MAP leaderless mRNA; mRNA_Map 9fra 4 77 2.8 RF00005 39753558 0030533 562 agcggggnggagcagccuggnagcucgucgggnucauaacccgaagaucgucggnucaaauccggcccccgcuacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(.(((.......))).)))))))..... Cryo-EM structure of Saccharolobus solfataricus 30S initiation complex bound to Ss-MAP leaderless mRNA; tRNA initiator Met 9fra s 10 2.8 39753558 273057 ugaggaugaa .......... .......... Cryo-EM structure of Saccharolobus solfataricus 30S initiation complex bound to Ss-MAP leaderless mRNA; mRNA_Map 9frk 2 1496 3.0 RF01959,RF00177,RF01960,RF02542 39753558 0003735 0005840 273057 aauccgguugauccngccggacccgaccgcuaucgggguggggcuaagccangggagucguacgcucccgggcaagggagcguggcggacggcugaguaacacguggcuaacnuacccugaggagggagauaaccccgggaaacuggggauaaucucccauaggcgaggaguccuggaacgguuccucgcugaaaggcucaugggcuauuccccgcucaugagcgccucaggauggggcugcggcncaucagguaguuggggggguaagggccccccaagccuauaacggguaggggccgugagagcgggagnccccaguugggcacugagacaagngcccaggcccuacggggcgcaccaggcgcgaaacguccccaaugcgcggaagcgugagggcnccaccccgagugcucccguaagggagcuuuuccccgcucuacaaaggcgggggaauaagcggggggcaagucuggugucagncgccgcgguaaunccagccccgcgaguggungggacucuuacugggccuaaagcgcncguagccngcccgacaagucacuccuuaaagaccccggcucaaccgggggaaugggggugauacugucgggcuagggggcgggagaggccagcgguacucccggaguaggggcgaaauccucagaucucgggangaccaccaguggcgaaagcggcuggcuagaacgcgccngacggugaggggcgaaagccggggcagcaaaagggauuagauaccccuguagucccggcuguaaacaaugcaggcuaggugucacaugggcuuagagcccauguggugccgcagggaagccguuaagccugcngccuggggaguacggucgcaanacugaaacuuaaaggaauuggcgggggagcaccacaaggnguggaaccugcggcucaauungagncaacgccuggaaucuuacuaggggagaccgcaggaugacggccaggcuaacgaccuugccugacucgcggagaggaggugcauggccnucgccagcucgugnugugaaauguccuguuaagucaggcaannagcgagacccccaccacuaguugguauccuggucuccgggccgggaccacacuagugggacugccggcguaagccggaggagggagggggccacggcaggucagcaugccccgaaaccccugggccgcacgcngguuacaauggcagggacagcgggauuccgaccccgaaaggggaagguaaucccuuaaacccugccgcaguugggaucgagggcugaaacucgcccucgugaacgaggaaucccuaguaaccgcagaucaacaaucugcggugaauacgncccugcuccuugcacacaccgncngucgcuccacccgaguaggagaggggugaggccccuugccuuuggguggggggucgagcuucucuccugcaaggggggagaagucguancaagguagnnguaggggnannugcggcuggaucaccucc ..<<<<<<.[.((((>>>>>><<<<<<<<<..<<<<<<.<<......<<<.<<<..<<<..<<<<<<<<(((...>>>>>>>>>>>......<<........<<<<<<<..<<...<<<<<<<.<<<<<...<<<<<<<....>>>>>>.>...>>>>>...<<<<<<<<<.<<......>>>>>>>>>>>.....<<<<<<<<<<.....)))>>>>>>>>>>.>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<............>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<<<....>>>>>>...<<<<<<<<.......>>>>>>>>.....<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<.....<<<<<<<<<..<<<<<<<.<..<<<......>>>.....>.>>>>>>>..>>.......<<....>>.>>>>>>>....>>>.>>>...>>>...>>>>...<<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>>.........<<<<<<..<<<<<<<<<<<<<<.....>>>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<.<<<<<<..<<<<<<<<<.......<<........>>..........<<<<<<<...<<<<<<......<<<.<<<.......>>>.>>>...>>.>>>>...<<.<<<..<<<<<<<<.....<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>....<<<<<.<<<<<<...<<..<<<<<<<......>>>>>>>>>....>>>>>>.....<<<<<....>>>>>........>>>>>.....>>.>>>...>>>>>>>>....>>>>>>>....>.>>>>>>>>.....<<<<<<<.....<<<...<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<...<<<<<<<<<<<<..<<<<<<<<<<<....>>>>>>>>>>>..>>>>>>>>>>>>...>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>........... ...((((..[.[[[..)))).(((((((((..((((((.(((.....(((.(((..(((..(((((((([[[...)))))))))))......(((.......(((((((..((...(((((((.(((((....((((((....)))))).....)))))...((((((((..((......)).)))))))).....((((((((((.....]]])))))))))).)))))))..))))))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((((....))))))..(.(((((((.......)))))))....).((((([[....(.((((.....((..]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((.....((((((((((.(((((((....((........)).......))))))).))).......((....)).)))))))....))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((((.....))))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..((((((((((......((........))..........(.(((((...((((((......(((.(((.......))).)))...)).))))...((.(((...((((((((....(((((((((....)))..((((......))))..))))))....(((((.(((((((..((..(((.((((....)))).)))))...)))))))..(..(((((....))))).....)..)))))....))).)))...)).)))))....))))).)...)).)))))))).(...(((((((.....(((...((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(.((((.(((..(.(((((((..((..((((((((.((....)).))))))))..))..))))))).)..))).))))..).))...)..)..(((((((((....)))))))))}.......... Cryo-EM structure of Saccharolobus solfataricus 30S initiation complex bound to SD mRNA; rRNA 16S 9frk 4 77 3.0 RF00005 39753558 0030533 562 agcggggnggagcagccuggnagcucgucgggnucauaacccgaagaucgucggnucaaauccggcccccgcuacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(.(((.......))).)))))))..... Cryo-EM structure of Saccharolobus solfataricus 30S initiation complex bound to SD mRNA; tRNA Met initiator 9frk 5 20 3.0 39753558 273057 uggaggugauuuaaaugcca .................... .................... Cryo-EM structure of Saccharolobus solfataricus 30S initiation complex bound to SD mRNA; mRNA aEF1A 9frl 2 1443 2.97 RF01959,RF00177,RF01960,RF02542 39753558 0003735 0005840 273057 aauccgguugauccngccggacccgaccgcuaucgggguggggcuaagccangggagucguacgcucccgggcaagggagcguggcggacggcugaguaacacguggcuaacnuacccugaggagggagauaaccccgggaaacuggggauaaucucccauaggcgaggaguccuggaacgguuccucgcugaaaggcucaugggcuauuccccgcucaugagcgccucaggauggggcugcggcncaucagguaguuggggggguaagggccccccaagccuauaacggguaggggccgugagagcgggagnccccaguugggcacugagacaagngcccaggcccuacggggcgcaccaggcgcgaaacguccccaaugcgcggaagcgugagggcnccaccccgagugcucccguaagggagcuuuuccccgcucuacaaaggcgggggaauaagcggggggcaagucuggugucagncgccgcgguaaunccagccccgcgaguggungggacucuuacugggccuaaagcgcncguagccngcccgacaagucacuccuuaaagaccccggcucaaccgggggaaugggggugauacugucgggcuagggggcgggagaggccagcgguacucccggaguaggggcgaaauccucagaucucgggangaccaccaguggcgaaagcggcuggcuagaacgcgccngacggugaggggcgaaagccggggcagcaaaagggauuagauaccccuguagucccggcuguaaacaaugcaggcuaggugucacaugggcuuagagcccauguggugccgcagggaagccguuaagccugcngccuggggaguacggucgcaanacugaaacuuaaaggaauuggcgggggagcaccacaaggnguggaaccugcggcucaauungagncaacgccuggaaucuuacuaggggagaccgcaggaugacggccaggcuaacgaccuugccugacucgcggagaggaggugcauggccnucgccagcucgugnugugaaauguccuguuaagucaggcaannagcgagacccccaccacuaguugguauccuggucuccgggccgggaccacacuagugggacugccggcguaagccggaggagggagggggccacggcaggucagcaugccccgaaaccccugggccgcacgcngguuacaauggcagggacagcgggauuccgaccccgaaaggggaagguaaucccuuaaacccugccgcaguugggaucgagggcugaaacucgcccucgugaacgaggaaucccuaguaaccgcagaucaacaaucugcggugaauacgncccugcuccuugcacacaccgncngucgcuccacccgaugcaaggggggagaagucguancaagguagnnguaggggnannugcggcuggaucaccucc ..<<<<<<.[.((((>>>>>><<<<<<<<<..<<<<<<.<<......<<<.<<<..<<<..<<<<<<<<(((...>>>>>>>>>>>......<<........<<<<<<<..<<...<<<<<<<.<<<<<...<<<<<<<....>>>>>>.>...>>>>>...<<<<<<<<<.<<......>>>>>>>>>>>.....<<<<<<<<<<.....)))>>>>>>>>>>.>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<............>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<<<....>>>>>>...<<<<<<<<.......>>>>>>>>.....<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<.....<<<<<<<<<..<<<<<<<.<..<<<......>>>.....>.>>>>>>>..>>.......<<....>>.>>>>>>>....>>>.>>>...>>>...>>>>...<<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>>.........<<<<<<..<<<<<<<<<<<<<<.....>>>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<.<<<<<<..<<<<<<<<<.......<<........>>..........<<<<<<<...<<<<<<......<<<.<<<.......>>>.>>>...>>.>>>>...<<.<<<..<<<<<<<<.....<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>....<<<<<.<<<<<<...<<..<<<<<<<<....>>>>>>>>>>....>>>>>>.....<<<<<....>>>>>........>>>>>.....>>.>>>...>>>>>>>>....>>>>>>>....>.>>>>>>>>.....<<<<<<<.....<<<...<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<.......>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>........... ...((((..[.[[[..)))).(((((((((..((((((.(((.....(((.(((..(((..(((((((([[[...)))))))))))......(((.......(((((((..((...(((((((.(((((....((((((....)))))).....)))))...((((((((..((......)).)))))))).....((((((((((.....]]])))))))))).)))))))..))))))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((((....))))))..(.(((((((.......)))))))....).((((([[....(.((((.....((..]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((.....((((((((((.(((((((....((........)).......))))))).))).......((....)).)))))))....))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((((.....))))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..((((((((((......((........))..........(.(((((...((((((......(((.(((.......))).)))...)).))))...((.(((...((((((((....(((((((((....)))..((((......))))..))))))....(((((.(((((((..((..(((.((((....)))).)))))...)))))))..(..(((((....))))).....)..)))))....))).)))...)).)))))....))))).)...)).)))))))).(...(((((((.....(((...((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(.((((.(((.......))).))))..).))...)..)..(((((((((....)))))))))}.......... Cryo-EM structure of Saccharolobus solfataricus 30S initiation complex bound to SD mRNA with h44 in up position; rRNA 16S 9frl 4 77 2.97 RF00005 39753558 0030533 562 agcggggnggagcagccuggnagcucgucgggnucauaacccgaagaucgucggnucaaauccggcccccgcuacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(.(((.......))).)))))))..... Cryo-EM structure of Saccharolobus solfataricus 30S initiation complex bound to SD mRNA with h44 in up position; tRNA Met initiator 9frl 5 20 2.97 39753558 29292 uggaggugauuuaaaugcca .................... .................... Cryo-EM structure of Saccharolobus solfataricus 30S initiation complex bound to SD mRNA with h44 in up position; mRNA 9fs6 2 1440 2.9 RF01959,RF00177,RF01960,RF02542 39753558 0003735 0005840 273057 aauccgguugauccngccggacccgaccgcuaucgggguggggcuaagccangggagucguacgcucccgggcaagggagcguggcggacggcugaguaacacguggcuaacnuacccugaggagggagauaaccccgggaaacuggggauaaucucccauaggcgaggaguccuggaacgguuccucgcugaaaggcucaugggcuauuccccgcucaugagcgccucaggauggggcugcggcncaucagguaguuggggggguaagggccccccaagccuauaacggguaggggccgugagagcgggagnccccaguugggcacugagacaagngcccaggcccuacggggcgcaccaggcgcgaaacguccccaaugcgcggaagcgugagggcnccaccccgagugcucccguaagggagcuuuuccccgcucuacaaaggcgggggaauaagcggggggcaagucuggugucagncgccgcgguaaunccagccccgcgaguggungggacucuuacugggccuaaagcgcncguagccngcccgacaagucacuccuuaaagaccccggcucaaccgggggaaugggggugauacugucgggcuagggggcgggagaggccagcgguacucccggaguaggggcgaaauccucagaucucgggangaccaccaguggcgaaagcggcuggcuagaacgcgccngacggugaggggcgaaagccggggcagcaaaagggauuagauaccccuguagucccggcuguaaacaaugcaggcuaggugucacaugggcuuagagcccauguggugccgcagggaagccguuaagccugcngccuggggaguacggucgcaanacugaaacuuaaaggaauuggcgggggagcaccacaaggnguggaaccugcggcucaauungagncaacgccuggaaucuuacuaggggagaccgcaggaugacggccaggcuaacgaccuugccugacucgcggagaggaggugcauggccnucgccagcucgugnugugaaauguccuguuaagucaggcaannagcgagacccccaccacuaguugguauccuggucuccgggccgggaccacacuagugggacugccggcguaagccggaggagggagggggccacggcaggucagcaugccccgaaaccccugggccgcacgcngguuacaauggcagggacagcgggauuccgaccccgaaaggggaagguaaucccuuaaacccugccgcaguugggaucgagggcugaaacucgcccucgugaacgaggaaucccuaguaaccgcagaucaacaaucugcggugaauacgncccugcuccuugcacacaccgncngucgcuccacccgaugcaaggggggagaagucguancaagguagnnguaggggnannugcggcuggaucacc ..<<<<<<.[.((((>>>>>><<<<<<<<<..<<<<<<.<<......<<<.<<<..<<<..<<<<<<<<(((...>>>>>>>>>>>......<<........<<<<<<<..<<...<<<<<<<.<<<<<...<<<<<<......>>>>>.>...>>>>>...<<<<<<<<<.<<......>>>>>>>>>>>.....<<<<<<<<<<.....)))>>>>>>>>>>.>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<............>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<<<....>>>>>>...<<<<<<<<.......>>>>>>>>.....<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<.....<<<<<<<<<..<<<<<<<.<..<<<......>>>.....>.>>>>>>>..>>.......<<....>>.>>>>>>>....>>>.>>>...>>>...>>>>...<<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>>.........<<<<<<..<<<<<<<<<<<<<<.....>>>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<...<<<<<<......<<<.<<<.......>>>.>>>...>>.>>>>...<<.<<<..<<<<<<<<.....<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>....<<<<<.<<<<<<...<<..<<<<<<<......>>>>>>>>>....>>>>>>.....<<<<<....>>>>>........>>>>>.....>>.>>>...>>>>>>>>....>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<...<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<.......>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>........ ...((((..[.[[[..)))).(((((((((..((((((.(((.....(((.(((..(((..(((((((([[[...)))))))))))......(((.......(((((((..((...(((((((.(((((....((((((....)))))).....)))))...((((((((..((......)).)))))))).....((((((((((.....]]])))))))))).)))))))..))))))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((((....))))))....(((((((.......)))))))......((((([[....(.((((.....((..]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((.....(((((((((..(((((((....((........)).......)))))))..)).......((....)).)))))))....))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((((.....))))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..((((((((((......((........))..........(.(((((...((((((......(((.(((.......))).)))...)).))))...((.(((...((((((((....(((((((((....)))..((((......))))..))))))....(((((.(((((((..((..(((.((((....)))).)))))...)))))))..(..(((((....))))).....)..)))))....))).)))...)).)))))....))))).)...)).)))))))).(...(((((((.....(((...((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(.((((.(((.......))).))))..).))...)..)..(((((((((....)))))))))}....... Cryo-EM structure of Saccharolobus solfataricus 30S initiation complex bound to Ss-aIF2beta leaderless mRNA with h44 in up position; rRNA 16S 9fs6 4 77 2.9 RF00005 39753558 0030533 562 agcggggnggagcagccuggnagcucgucgggnucauaacccgaagaucgucggnucaaauccggcccccgcuacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(.(((.......))).)))))))..... Cryo-EM structure of Saccharolobus solfataricus 30S initiation complex bound to Ss-aIF2beta leaderless mRNA with h44 in up position; tRNA met initiator 9fs8 2 1493 3.7 RF01959,RF00177,RF01960,RF02542 39753558 0003735 0005840 273057 aauccgguugauccngccggacccgaccgcuaucgggguggggcuaagccangggagucguacgcucccgggcaagggagcguggcggacggcugaguaacacguggcuaacnuacccugaggagggagauaaccccgggaaacuggggauaaucucccauaggcgaggaguccuggaacgguuccucgcugaaaggcucaugggcuauuccccgcucaugagcgccucaggauggggcugcggcncaucagguaguuggggggguaagggccccccaagccuauaacggguaggggccgugagagcgggagnccccaguugggcacugagacaagngcccaggcccuacggggcgcaccaggcgcgaaacguccccaaugcgcggaagcgugagggcnccaccccgagugcucccguaagggagcuuuuccccgcucuacaaaggcgggggaauaagcggggggcaagucuggugucagncgccgcgguaaunccagccccgcgaguggungggacucuuacugggccuaaagcgcncguagccngcccgacaagucacuccuuaaagaccccggcucaaccgggggaaugggggugauacugucgggcuagggggcgggagaggccagcgguacucccggaguaggggcgaaauccucagaucucgggangaccaccaguggcgaaagcggcuggcuagaacgcgccngacggugaggggcgaaagccggggcagcaaaagggauuagauaccccuguagucccggcuguaaacaaugcaggcuaggugucacaugggcuuagagcccauguggugccgcagggaagccguuaagccugcngccuggggaguacggucgcaanacugaaacuuaaaggaauuggcgggggagcaccacaaggnguggaaccugcggcucaauungagncaacgccuggaaucuuacuaggggagaccgcaggaugacggccaggcuaacgaccuugccugacucgcggagaggaggugcauggccnucgccagcucgugnugugaaauguccuguuaagucaggcaannagcgagacccccaccacuaguugguauccuggucuccgggccgggaccacacuagugggacugccggcguaagccggaggagggagggggccacggcaggucagcaugccccgaaaccccugggccgcacgcngguuacaauggcagggacagcgggauuccgaccccgaaaggggaagguaaucccuuaaacccugccgcaguugggaucgagggcugaaacucgcccucgugaacgaggaaucccuaguaaccgcagaucaacaaucugcggugaauacgncccugcuccuugcacacaccgncngucgcuccacccgaguaggagaggggugaggccccuugccuuuggguggggggucgagcuucucuccugcaaggggggagaagucguancaagguagnnguaggggnannugcggcuggaucacc ..<<<<<<.[.((((>>>>>><<<<<<<<<..<<<<<<.<<......<<<.<<<..<<<..<<<<<<<<(((...>>>>>>>>>>>......<<........<<<<<<<..<<...<<<<<<<.<<<<<...<<<<<<<....>>>>>>.>...>>>>>...<<<<<<<<<.<<......>>>>>>>>>>>.....<<<<<<<<<<.....)))>>>>>>>>>>.>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<............>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<<<....>>>>>>...<<<<<<<<.......>>>>>>>>.....<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<.....<<<<<<<<<..<<<<<<<.<..<<<......>>>.....>.>>>>>>>..>>.......<<....>>.>>>>>>>....>>>.>>>...>>>...>>>>...<<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>>.........<<<<<<..<<<<<<<<<<<<<<.....>>>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<.<<<<<<..<<<<<<<<<.......<<........>>..........<<<<<<<...<<<<<<......<<<.<<<.......>>>.>>>...>>.>>>>...<<.<<<..<<<<<<<<.....<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>....<<<<<.<<<<<<...<<..<<<<<<<......>>>>>>>>>....>>>>>>.....<<<<<....>>>>>........>>>>>.....>>.>>>...>>>>>>>>....>>>>>>>....>.>>>>>>>>.....<<<<<<<.....<<<...<<..<<<<....>>>>..>>....>>>.....>>>>>>>...........<<<<<<<........>>>>>>>..........>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<...<<<<<<<<<<<<..<<<<<<<<<<<....>>>>>>>>>>>..>>>>>>>>>>>>...>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>........ ...((((..[.[[[..)))).(((((((((..((((((.(((.....(((.(((..(((..(((((((([[[...)))))))))))......(((.......(((((((..((...(((((((.(((((....((((((....)))))).....)))))...((((((((..((......)).)))))))).....((((((((((.....]]])))))))))).)))))))..))))))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((((....))))))..(.(((((((.......)))))))....).((((([[....(.((((.....((..]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((.....((((((((((.(((((((....((........)).......))))))).))).......((....)).)))))))....))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((((.....))))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..((((((((((......((........))..........(.(((((...((((((......(((.(((.......))).)))...)).))))...((.(((...((((((((....(((((((((....)))..((((......))))..))))))....(((((.(((((((..((..(((.((((....)))).)))))...)))))))..(..(((((....))))).....)..)))))....))).)))...)).)))))....))))).)...)).)))))))).(...(((((((.....(((...((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(.((((.(((..(.(((((((..((..((((((((.((....)).))))))))..))..))))))).)..))).))))..).))...)..)..(((((((((....)))))))))}....... Cryo-EM structure of Saccharolobus solfataricus 30S initiation complex bound to Ss-aEF1A-like mRNA; rRNA 16S 9fs8 4 77 3.7 RF00005 39753558 0030533 562 agcggggnggagcagccuggnagcucgucgggnucauaacccgaagaucgucggnucaaauccggcccccgcuacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(.(((.......))).)))))))..... Cryo-EM structure of Saccharolobus solfataricus 30S initiation complex bound to Ss-aEF1A-like mRNA; tRNA met initiator 9fsf 2 1451 2.8 RF01959,RF00177,RF01960,RF02542 39753558 0003735 0005840 273057 aauccgguugauccngccggacccgaccgcuaucgggguggggcuaagccangggagucguacgcucccgggcaagggagcguggcggacggcugaguaacacguggcuaacnuacccugaggagggagauaaccccgggaaacuggggauaaucucccauaggcgaggaguccuggaacgguuccucgcugaaaggcucaugggcuauuccccgcucaugagcgccucaggauggggcugcggcncaucagguaguuggggggguaagggccccccaagccuauaacggguaggggccgugagagcgggagnccccaguugggcacugagacaagngcccaggcccuacggggcgcaccaggcgcgaaacguccccaaugcgcggaagcgugagggcnccaccccgagugcucccguaagggagcuuuuccccgcucuacaaaggcgggggaauaagcggggggcaagucuggugucagncgccgcgguaaunccagccccgcgaguggungggacucuuacugggccuaaagcgcncguagccngcccgacaagucacuccuuaaagaccccggcucaaccgggggaaugggggugauacugucgggcuagggggcgggagaggccagcgguacucccggaguaggggcgaaauccucagaucucgggangaccaccaguggcgaaagcggcuggcuagaacgcgccngacggugaggggcgaaagccggggcagcaaaagggauuagauaccccuguagucccggcuguaaacaaugcaggcuaggugucacaugggcuuagagcccauguggugccgcagggaagccguuaagccugcngccuggggaguacggucgcaanacugaaacuuaaaggaauuggcgggggagcaccacaaggnguggaaccugcggcucaauungagncaacgccuggaaucuuacuaggggagaccgcaggaugacggccaggcuaacgaccuugccugacucgcggagaggaggugcauggccnucgccagcucgugnugugaaauguccuguuaagucaggcaannagcgagacccccaccacuaguugguauccuggucuccgggccgggaccacacuagugggacugccggcguaagccggaggagggagggggccacggcaggucagcaugccccgaaaccccugggccgcacgcngguuacaauggcagggacagcgggauuccgaccccgaaaggggaagguaaucccuuaaacccugccgcaguugggaucgagggcugaaacucgcccucgugaacgaggaaucccuaguaaccgcagaucaacaaucugcggugaauacgncccugcuccuugcacacaccgncngucgcuccacccgaguaggaccugcaaggggggagaagucguancaagguagnnguaggggnannugcggcuggaucaccucc ..<<<<<<.[.((((>>>>>><<<<<<<<<..<<<<<<.<<......<<<.<<<..<<<..<<<<<<<<(((...>>>>>>>>>>>......<<........<<<<<<<..<<...<<<<<<<.<<<<<...<<<<<<......>>>>>.>...>>>>>...<<<<<<<<<.<<......>>>>>>>>>>>.....<<<<<<<<<<.....)))>>>>>>>>>>.>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<............>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<<<....>>>>>>...<<<<<<<<.......>>>>>>>>.....<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<.....<<<<<<<<<..<<<<<<<.<..<<<......>>>.....>.>>>>>>>..>>.......<<....>>.>>>>>>>....>>>.>>>...>>>...>>>>...<<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>>.........<<<<<<..<<<<<<<<<<<<<<.....>>>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<...<<<<<<......<<<.<<<.......>>>.>>>...>>.>>>>...<<.<<<..<<<<<<<<.....<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>....<<<<<.<<<<<<...<<..<<<<<<<......>>>>>>>>>....>>>>>>.....<<<<<....>>>>>........>>>>>.....>>.>>>...>>>>>>>>....>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<...<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<...<<<<.>>>>...>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>........... ...((((..[.[[[..)))).(((((((((..((((((.(((.....(((.(((..(((..(((((((([[[...)))))))))))......(((.......(((((((..((...(((((((.(((((....((((((....)))))).....)))))...((((((((..((......)).)))))))).....((((((((((.....]]])))))))))).)))))))..))))))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((((....))))))..(.(((((((.......)))))))....).((((([[....(.((((.....((..]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((.....((((((((((.(((((((....((........)).......))))))).))).......((....)).)))))))....))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((((.....))))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..((((((((((......((........))........(.(.(((((...((((((......(((.(((.......))).)))...)).))))...((.(((...((((((((....(((((((((....)))..((((......))))..))))))....(((((.(((((((..((..(((.((((....)))).)))))...)))))))..(..(((((....))))).....)..)))))....))).)))...)).)))))....))))).))..)).)))))))).(...(((((((.....(((...((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(.((((.(((..(.(((.))).)..))).))))..).))...)..)..(((((((((....)))))))))}.......... Cryo-EM structure of Saccharolobus solfataricus 30S initiation complex bound to Ss-MAP leaderless mRNA with h44 in up position; rRNA 16S 9fsf 5 13 2.8 39753558 273057 ugacugaggauga ............. ............. Cryo-EM structure of Saccharolobus solfataricus 30S initiation complex bound to Ss-MAP leaderless mRNA with h44 in up position; mRNA Map 9fsf 4 77 2.8 RF00005 39753558 0030533 562 agcggggnggagcagccuggnagcucgucgggnucauaacccgaagaucgucggnucaaauccggcccccgcuacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(.(((.......))).)))))))..... Cryo-EM structure of Saccharolobus solfataricus 30S initiation complex bound to Ss-MAP leaderless mRNA with h44 in up position; tRNA Met initiator 9fsf s 10 2.8 39753558 273057 ugaggaugaa .......... .......... Cryo-EM structure of Saccharolobus solfataricus 30S initiation complex bound to Ss-MAP leaderless mRNA with h44 in up position; mRNA Map 9fvd S 18 3.2 39604358 33727 agacacacaaaaacaaga .................. .................. Cryo-EM structure of single-layered nucleoprotein-RNA helical assembly from Marburg virus, trimeric repeat unit; RNA (5'-R(P*AP*GP*AP*CP*AP*CP*AP*CP*AP*AP*AP*AP*AP*CP*AP*AP*GP*A)-3') 9fvd R 12 3.2 39604358 33727 acaaaaacaaga ............ ............ Cryo-EM structure of single-layered nucleoprotein-RNA helical assembly from Marburg virus, trimeric repeat unit; RNA (5'-R(P*AP*GP*AP*CP*AP*CP*AP*CP*AP*AP*AP*AP*AP*CP*AP*AP*GP*A)-3') 9fvd U 12 3.2 39604358 33727 agacacacaaaa ............ ............ Cryo-EM structure of single-layered nucleoprotein-RNA helical assembly from Marburg virus, trimeric repeat unit; RNA (5'-R(P*AP*GP*AP*CP*AP*CP*AP*CP*AP*AP*AP*AP*AP*CP*AP*AP*GP*A)-3') 9fy0 2 1494 2.9 RF01959,RF00177,RF01960,RF02542 39753558 0003735 0005840 273057 aauccgguugauccngccggacccgaccgcuaucgggguggggcuaagccangggagucguacgcucccgggcaagggagcguggcggacggcugaguaacacguggcuaacnuacccugaggagggagauaaccccgggaaacuggggauaaucucccauaggcgaggaguccuggaacgguuccucgcugaaaggcucaugggcuauuccccgcucaugagcgccucaggauggggcugcggcncaucagguaguuggggggguaagggccccccaagccuauaacggguaggggccgugagagcgggagnccccaguugggcacugagacaagngcccaggcccuacggggcgcaccaggcgcgaaacguccccaaugcgcggaagcgugagggcnccaccccgagugcucccguaagggagcuuuuccccgcucuacaaaggcgggggaauaagcggggggcaagucuggugucagncgccgcgguaaunccagccccgcgaguggungggacucuuacugggccuaaagcgcncguagccngcccgacaagucacuccuuaaagaccccggcucaaccgggggaaugggggugauacugucgggcuagggggcgggagaggccagcgguacucccggaguaggggcgaaauccucagaucucgggangaccaccaguggcgaaagcggcuggcuagaacgcgccngacggugaggggcgaaagccggggcagcaaaagggauuagauaccccuguagucccggcuguaaacaaugcaggcuaggugucacaugggcuuagagcccauguggugccgcagggaagccguuaagccugcngccuggggaguacggucgcaanacugaaacuuaaaggaauuggcgggggagcaccacaaggnguggaaccugcggcucaauungagncaacgccuggaaucuuacuaggggagaccgcaggaugacggccaggcuaacgaccuugccugacucgcggagaggaggugcauggccnucgccagcucgugnugugaaauguccuguuaagucaggcaannagcgagacccccaccacuaguugguauccuggucuccgggccgggaccacacuagugggacugccggcguaagccggaggagggagggggccacggcaggucagcaugccccgaaaccccugggccgcacgcngguuacaauggcagggacagcgggauuccgaccccgaaaggggaagguaaucccuuaaacccugccgcaguugggaucgagggcugaaacucgcccucgugaacgaggaaucccuaguaaccgcagaucaacaaucugcggugaauacgncccugcuccuugcacacaccgncngucgcuccacccgaguaggagaggggugaggccccuugccuuuggguggggggucgagcuucucuccugcaaggggggagaagucguancaagguagnnguaggggnannugcggcuggaucaccu ..<<<<<<.[.((((>>>>>><<<<<<<<<..<<<<<<.<<......<<<.<<<..<<<..<<<<<<<<(((...>>>>>>>>>>>......<<........<<<<<<<..<<...<<<<<<<.<<<<<...<<<<<<......>>>>>.>...>>>>>...<<<<<<<<<.<<......>>>>>>>>>>>.....<<<<<<<<<<.....)))>>>>>>>>>>.>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<............>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<<<....>>>>>>...<<<<<<<<.......>>>>>>>>.....<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<.....<<<<<<<<<..<<<<<<<.<..<<<......>>>.....>.>>>>>>>..>>.......<<....>>.>>>>>>>....>>>.>>>...>>>...>>>>...<<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>>.........<<<<<<..<<<<<<<<<<<<<<.....>>>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<.<<<<<<..<<<<<<<<<.......<<........>>..........<<<<<<<...<<<<<<......<<<.<<<.......>>>.>>>...>>.>>>>...<<.<<<..<<<<<<<<.....<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>....<<<<<.<<<<<<<..<<..<<<<<<<......>>>>>>>>>...>>>>>>>.....<<<<<....>>>>>........>>>>>.....>>.>>>...>>>>>>>>....>>>>>>>....>.>>>>>>>>.....<<<<<<<.....<<<...<<..<<<<....>>>>..>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<<..<<<<<<<<<<<....>>>>>>>>>>>..>>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..)))).(((((((((..((((((.(((.....(((.(((..(((..(((((((([[[...)))))))))))......(((.......(((((((..((...(((((((.(((((....((((((....)))))).....)))))...((((((((..((......)).)))))))).....((((((((((.....]]])))))))))).)))))))..))))))))).(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((((....))))))....(((((((.......)))))))......((((([[....(.((((.....((..]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((.....(((((((((..(((((((....((........)).......)))))))..)).......((....)).)))))))....))).)))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((((.....))))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((..((..(((((..((((((((.(......((........))..........(.(((((...((((((......(((.(((.......))).)))...)).))))...((.(((...((((((((....(((((((((....)))..((((......))))..))))))....(((((.(((((((..((..(((.((((....)))).)))))...)))))))..(..(((((....))))).....)..)))))....))).)))...)).)))))....))))).)...)..)))))))).(...(((((((.....(((...((..((((....))))..))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....((((((((.......))))))))......))...)))))))))).))..(.(..((.(.((((.(((..(.(((((((..((..(((((((((((....)))))))))))..))..))))))).)..)))).)))..).))...)..)..(((((((((....)))))))))}........ Cryo-EM structure of Saccharolobus solfataricus 30S initiation complex bound to Ss-aIF2beta leaderless mRNA; rRNA 16S 9fy0 4 77 2.9 RF00005 39753558 0030533 562 agcggggnggagcagccuggnagcucgucgggnucauaacccgaagaucgucggnucaaauccggcccccgcuacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(.(((.......))).)))))))..... Cryo-EM structure of Saccharolobus solfataricus 30S initiation complex bound to Ss-aIF2beta leaderless mRNA; tRNA met initiator 9g6k l0 44 2.89 39690155,28710774,32881101,29872003 5811 aacaggugccaggccaacaagaauccgauccguguauuccguac ....<<.....((>>.......<<.<.......>.>>.)).... ....((.....[[)).....(.((.(.......).)))]].... LSU structure derived from the LSU sample of the mitoribosome from T. gondii.; RNA23t 9g6k l1 50 2.89 39690155,28710774,32881101,29872003 5811 uucguugacuguguuuaccacggggaauuagaacagaauaucaaaaaaaa ........<<<<....................>>>>.............. ........(.((....................)).).............. LSU structure derived from the LSU sample of the mitoribosome from T. gondii.; RNA29 9g6k l2 31 2.89 39690155,28710774,32881101,29872003 5811 auguuugcuuggaagcuguagucauuaaaaa <<....<<.........>>....>>...... .(.....(.........).....)....... LSU structure derived from the LSU sample of the mitoribosome from T. gondii.; LSUB 9g6k l3 59 2.89 39690155,28710774,32881101,29872003 5811 ugauauaauuaucguacaagcacucagcuaguuauugagagacacucacgagcccaaaa ........<..........>....................................... ........((........))....................................... LSU structure derived from the LSU sample of the mitoribosome from T. gondii.; RNA6 9g6k l4 94 2.89 39690155,28710774,32881101,29872003 5811 ccuuuuaauugauuaugcugacuuuagucccgauaaacuacaguucugcuuaaacugaggagucaaguagguacaaaccguacaaggauuaauu ..................................<.........>.........................<.......>............... ..................................(.........).........................(.......)............... LSU structure derived from the LSU sample of the mitoribosome from T. gondii.; RNA1 9g6k l5 36 2.89 39690155,28710774,32881101,29872003 5811 aucauuguguuaugguucuaucgcaaaccauugaga .................................... .................................... LSU structure derived from the LSU sample of the mitoribosome from T. gondii.; RNA31 9g6k l6 50 2.89 39690155,28710774,32881101,29872003 5811 acaggaucaaaucuuccuugagcgacucgacaggcaaaaaaaaaaaaaaa ..<<<<........>>>>................................ ..(((((..)....))))................................ LSU structure derived from the LSU sample of the mitoribosome from T. gondii.; RNA14 9g6k l7 69 2.89 39690155,28710774,32881101,29872003 5811 uugcguacauuccuuaauaucuggaacgauagauuaugauuagguaguggaaaaaaaaaaaaaaaaaaa ..............<<<......................>>>........................... ..............(((.....(...(....)..)....)))........................... LSU structure derived from the LSU sample of the mitoribosome from T. gondii.; RNA11 9g6k l8 33 2.89 39690155,28710774,32881101,29872003 5811 agggcaugcaauaccaaucagauaacaacugaa ................................. ................................. LSU structure derived from the LSU sample of the mitoribosome from T. gondii.; RNA36 9g6k l9 91 2.89 39690155,28710774,32881101,29872003 5811 uccuauuuccuaguaccauuagugaacucauuuggucugauccuaaguacgcagugagcuaaauagauacaaggaacuugacaagcauuac ........................................................................................... ........................................................................................... LSU structure derived from the LSU sample of the mitoribosome from T. gondii.; RNA3 9g6k lA 65 2.89 39690155,28710774,32881101,29872003 5811 ggacuccuuaacuuaaacugaggagucaaguagguacaaaccguacaaggauuaauuauguccaa .<<<<<<<<<........>>>>>>>>>.....<<......>>....................... ..((((((.(........).))))))......((......))....................... LSU structure derived from the LSU sample of the mitoribosome from T. gondii.; RNA2 9g6k lB 45 2.89 39690155,28710774,32881101,29872003 5811 ugugugagaaggagcuauacagauacaggcgaaggagaagcggga ............................................. ............................................. LSU structure derived from the LSU sample of the mitoribosome from T. gondii.; RNA38 9g6k lC 27 2.89 39690155,28710774,32881101,29872003 5811 uguaacgguacaagcuguaaacaaagg ......<<<....>>>........... ......(((....)))........... LSU structure derived from the LSU sample of the mitoribosome from T. gondii.; RNA35 9g6k lD 16 2.89 39690155,28710774,32881101,29872003 5811 auuaacauaacaacau ................ ................ LSU structure derived from the LSU sample of the mitoribosome from T. gondii.; RNA32 9g6k lE 29 2.89 39690155,28710774,32881101,29872003 5811 cggcgagaagggaaguguguuucaaagaa ..........<<<<.....>>>>...... ..........((((.....))))...... LSU structure derived from the LSU sample of the mitoribosome from T. gondii.; RNA15 9g6k lF 88 2.89 39690155,28710774,32881101,29872003 5811 gagucuagcuucaguuguuaucugauugguauugcaugcccugaguacguaaggaaaaggaaagguuaaccgcuauuuaaacaaaaaa .......................................<<<...............>>>............................ .......................................(((.....(....)....)))............................ LSU structure derived from the LSU sample of the mitoribosome from T. gondii.; RNA10 9g6k lG 26 2.89 39690155,28710774,32881101,29872003 5811 cuaaagauagcgugaaagcucaaaaa ........<<<......>>>...... ........(((......)))...... LSU structure derived from the LSU sample of the mitoribosome from T. gondii.; LSUC 9g6k lH 27 2.89 39690155,28710774,32881101,29872003 5811 uucuuggcauaacguuguguaguuaaa ........................... ........................... LSU structure derived from the LSU sample of the mitoribosome from T. gondii.; RNA16 9g6k lI 48 2.89 39690155,28710774,32881101,29872003 5811 aagggauguuuagccgggaaguuagcgucuaacaaaaaaaaaaaaaaa ............<.........>......................... ................................................ LSU structure derived from the LSU sample of the mitoribosome from T. gondii.; RNA13 9g6k lJ 279 2.89 RF02541,RF02540 39690155,28710774,32881101,29872003 0003735 0005840 5811 aggagagcgucuguuguacaucaacacuagauaccgcuaauaccacuguagagguauaguauauaaucccugcccggugcaguaacauguaaacggcggcuguugacgguccaaagguaggaaaauccuugucggguaauuaucgucgugcgugaaaguugguccgacucuucacaugucguuuaucuaaaacuuuuugaaauagaauuaucuuugaauaugaggaucgagauggcccgacgguuagacccugagcaccuuuacaucccuuaaaucaaa .<<<<<<<<..<<<<.......>>>>..<.<<<<......<<<....>>>........>>>>.>..............<<<......>>>........<<<<....>>>>.........<..........<.<<<.......>>>.>.....>...........>>.>>>>>>....................................<<<<<........>>>>>.................................................... .(((((.((...((.........))...(..(((......(((....)))........)))..).......((.......(......).......)).((........)).........(..........(.((.........)).).....)...........))..))))).....................................((((........))))..................................................... LSU structure derived from the LSU sample of the mitoribosome from T. gondii.; LSUD/E 9g6k lK 38 2.89 39690155,28710774,32881101,29872003 5811 acacagucgguacgaagucgaaacaagguaguugaugg .......................<<<.....>>>.... ........................((.....))..... LSU structure derived from the LSU sample of the mitoribosome from T. gondii.; SSUF 9g6k lL 91 2.89 39690155,28710774,32881101,29872003 5811 ugggagcgaagauaaucuaauauguaacuccguucauggaaaucaaaagagcuuucacugauuguauuuaugaaacgugaaaaaaaaaaaa ..<<<<.....<<......>>......>>>>...........<<....>>...<<<<<....<<......>>....>>>>>.......... ..((((.....((......))......))))...........(......)....((((.....((....)).....))))........... LSU structure derived from the LSU sample of the mitoribosome from T. gondii.; RNA7 9g6k lM 194 2.89 RF02541,RF02540,RF02543 39690155,28710774,32881101,29872003 0003735 0005840 5811 auauaacggucguaagguacgccggggauaacaggucagauaauauugggaguucuaauccucggauuguaucagcaccuccaugucggcucauuacucccuuguuauugaacaagauucaguuaggaacgauaguucaccgucagauguaauacgugagcugggugucuggagacaguuuguucccuaucuac ................................<<.<..<<<<<<.<.<<<<.......>>>>.>.>>>>..>>...>.>>.......<<<..<<<<...<<<<<...<<......>>..>>...>>>.<<...........>>......>>>>......>>>................................ ......................................((.(((.(.((((.......)))).).)))...)).............(.((.(((((...(((((...............))...))).(.............)......))))..)...)).)............................... LSU structure derived from the LSU sample of the mitoribosome from T. gondii.; LSUF/G 9g6k lN 62 2.89 39690155,28710774,32881101,29872003 5811 accggugguuuguuaguauuuaugucaucaacaugucaaugaaauaucaauaacgaugaaaa ......................<<....>>................................ .......................(....)..................(......)....... LSU structure derived from the LSU sample of the mitoribosome from T. gondii.; RNA37 9g6k lO 180 2.89 RF02541 39690155,28710774,32881101,29872003 0003735 0005840 5811 guuaguaugaucucaaaguaccagaagccaugugaucuauauaguauaacgggacauuagaccgaaccugcgauagauaaauauaucuuggaugauuguauauuagcggcuaaaugucaaucaaacaugcgaauuuuagguuuuccaugaaaucuauuuggaagaagaggcuugaaaaaa ....................<<....<.<<<<<.....<.....<<<<<..<<........>>...<<...<<<<........>>>>..>>....>>>>>...>...<<<.....>>>......>>>>>....>....>>............<<<..........>>>............ ....................((.....((((((.....(.....((.((..((........))...((...((((........))))..))....)).))...).(.(((.....)))...)..))))).).......))............(((..........)))............ LSU structure derived from the LSU sample of the mitoribosome from T. gondii.; LSUA 9g6k lP 29 2.89 39690155,28710774,32881101,29872003 5811 uuuuuuuuuuuuuuuuuuuuuuuuuuuuu ............................. ............................. LSU structure derived from the LSU sample of the mitoribosome from T. gondii.; ulr1 9g6k lQ 37 2.89 39690155,28710774,32881101,29872003 5811 uuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuu ..................................... ..................................... LSU structure derived from the LSU sample of the mitoribosome from T. gondii.; ulr2 9g6k lR 28 2.89 39690155,28710774,32881101,29872003 5811 uuuuuuuuuuuuuuuuuuuuuuuuuuuu ............................ ............................ LSU structure derived from the LSU sample of the mitoribosome from T. gondii.; ulr3 9g6k lT 14 2.89 39690155,28710774,32881101,29872003 5811 uuuuuuuuuuuuuu .............. .............. LSU structure derived from the LSU sample of the mitoribosome from T. gondii.; ulr5 9g6k lV 10 2.89 39690155,28710774,32881101,29872003 5811 uuuuuuuuuu .......... .......... LSU structure derived from the LSU sample of the mitoribosome from T. gondii.; ulr7,ulr8 9g6k lW 14 2.89 39690155,28710774,32881101,29872003 5811 uuuuuuuuuuuuuu .............. .............. LSU structure derived from the LSU sample of the mitoribosome from T. gondii.; ulr5 9g6k lX 58 2.89 39690155,28710774,32881101,29872003 5811 uuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuu .......................................................... .......................................................... LSU structure derived from the LSU sample of the mitoribosome from T. gondii.; ulr9 9g8m X 194 3.3 RF00458 39385025 0043022 12136 aaaaaugugaucuugcuuguaaauacaauuuugagagguuaauaaauuacaaguagugcuauuuuuguauuuagguuagcuauuuagcuuuacguuccaggaugccuaguggcagccccacaauauccaggaagcccauuuuuaaaaaaauuuuuuuuuuuuuuuuuuuuuuuuuucuccucuuuuuuuuuuuu .<<<<.........<<<<<<<<........................>>>>>>>>.......>>>>......<<<<<.<<<<....>>>>.....((((..((.>>>>><<<.......>>>....))..))))............................................................. .(.((.........(((((((..........................))))))).......)).)......(((((.((((....)))).....[[[....[[)))))(((.......)))...]]....]]]............................................................. human 80S ribosome bound by a SKI2-exosome complex; CrPV-IRES RNA 9g8m S2 1742 3.3 RF01960,RF02542,RF01959,RF00177 39385025 0003735 0005840 9606 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucgcuccucucccacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgccccccguggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuccgcgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcgggcguccccgccgccucucggccggggcccgaagcauuuacuuugaaaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgacccccgagcggucggcgucccccaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggucggcccacggcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<.<..<<....<<<....................<<.....<<..<.......>..>>......>>.........<<<<...<<<<<......>>>>>...>>>><...<<<<<...<......>..>>>>>........>..<<<<.<<<........>>>>>>>....>>>...>>>.>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>...<<....>>.....>>>>>>.........<<<....<<<.....>>>..>>>..>...>>.>.....<<.<<<<<...............>>>>>..>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<.................................................<<<<<<.<.......<<...<.......>..<<<.......>>>....>>......>.>>>..>>>.......<<....<<.<<<.................>>>.>>...>>.....>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>.>.>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<........<<........>>..........<<..<.<....<<<<<..................................>>>>>...<<.<<<..<<.<<.<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<.<<.....<..........<<......>>..........>....>>.>..>.....<<<<<.....>>>>>........>>>....>>>..>>.....>>>>>>>.....>.>..>>......>>>>.>>>.....<<.<<<................<<<.<<<<....>>>>.>>>..............>>>.>>......<.....<<<<<..........>>>>>.....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<.................................>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>......<<<<<<<<....>>>>>>>>.......... ...((((..[.[[[..))))(((.((.(((...(.((..((.....(((.(((..((....((.....(..........)....))[))......(((.......(((.(.(..((....((((....................(.....((..((.....))..))......)...........(((...((((........))))...))).....(((((...(......)..)))))............(((...((......))..)))...).)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).).....((.(((.(...............).)))..))......((..(...........)..)).........((((([[......((((.....((..]])).......)))).)))))..))).)).)))..[......(.([[...(.(.((...(((..(................................................((((((.(.......((..((.......)).((.........))....))......).)))..))).............(.(..((...............))...)).........)....(((.((...(...((((..((..((((((((...((........))......))))))))..)).......((....))...))))..)...))..))..))))...)).)....((((((....(...((((.........))))...).))))))......{...(((.((.(((..(.((((((.(((........))))))))).)..)))...((..]]))...))...].))))).).(((......((((....))))....)))...]]].]((.((.(((((((..((..((..(..(((..(((((......((........))..........((..(.(....(..........................................)...((.(((...(...((((.(..(((.(((((....)))..(.((......)))...)).)))....(((...(....(((................(.(....).)...............)))...)..(..(((((.....)))))....)...))).)..)))..)......).))))).....)..).))...)).)))..))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....(((.(..........).))).....)..)..)..)).....(..((.((.......)).))..)......))...)))))))))..))..(.(..((.(..((((.((..(.((((((((.(((..((((.((...((((...................................))))...)).))))..))).)))))))))..)).))))...).))...)..)..(((((((((....)))))))))}........ human 80S ribosome bound by a SKI2-exosome complex; 18S ribosomal RNA 9g8m L5 3654 3.3 RF02540,RF02543,RF02541 39385025 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugucggcggcccggcggaucuuucccgcgcgggggaccgucccccgaccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucggccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagacccgucgccgcgcucuccccccucccggcgccgccggggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccgggggaggggccacgcgcgcgucccccgaagagggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucccgaggccucuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcacacgcaguuuuauccgguaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcgugagccgggcguggaauggagugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauauagacagcaggacgguggccauggaagucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggagcggcgggggcggcgcgcgcgcgcgcccgcccccggagccccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucuccaaggugaacagccucuggcauguuggaacaauguagguaagggaagucggcaagccggauccguaacuucgggauaaggauuggcucuaagggcugggucggucgucggccggcgccuagcagccgacuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucuggcacggugaagauuuucacugacccggugaggcgggggggcgagccccgaggggcucucgcuucuggcgccaagcgcccggccgcgcgccggccgggcgcgacccgcuccggggacagugccagguggggaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugaugauguguuguugccaugguaauccugcucaguacgagaggaaccgcagguucagacauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccggucccccgcgggguccggugcggagugcccuucguccugggaaacggggcgcggccggagaggcggccgcccccucgcccgucacgcacgccguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..[[[..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>>..<<<<<<<<<......<<<<<<.<......<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>..>>>>>>>.....>>>>>>>>>.......<<<<<<<........>>>>>>>.....(((((..<<<<<<)))))..]]]..................................<<....>>...............<<<......>>>..................................<<<<<<<<..<<<.......<<<<<<<.<<<.....<<<<<<<<<<<...<<<.<..<<<<<......<<<<<.<<...<<<....>>>.>>>>>>>..>>>>>.>....>>>.>>>>>>>>>>>......>>>.>>>.>>>>...<<<<<<<<.<<<<<<<<<<.<<<....<...<.<<<<.<<<.......<<<<<..>>>>>........>>>.>>>>>.........>.>>>...>>>>>>>>>>....................<<<<<...<<<<.................>>>>...<<.<<..<<<.<<<<<<<<<<<<<<<<<<<<<<..<.<........>>...>>>>>>>>>.>>>>>>>>>>.>>>...>.>>...>>.>..>......<<<..<.......>..>>>.........>>>>>......>>>.>>>>>....>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<<......>>>>>>>..<<<<<...<<<..<<<.....{..[[.>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.<<<<<<<............<<<<<<<<<...<<<....<<<..<.<<<....<<.............>>..>>>.>..>>>..>>.>...>>>>>>>...<<<<<<<<<........>>>>>>>>>...>>...>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<........<<<<....................................<........>....>>>>....>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<..........]]...}.......................................................>>>>>>>>>....>>>>>>.<<<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>.>>.....>>>>>><<<....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<...........>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<....<<<.....<<<<<<<....>>>>>>>...<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..{{{..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>.............>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<........................>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>..<<<..<<<..<<<<<<.....<<.....<<<<....>>>>.....>>..>>>>..>>>>>.<<............>.>.........<...........<<<<<.......>>>>>.....>.....>>.>..>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>...>>>....<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<<<<<<<.<<<<<<..>>>>>>...<<<<<.....<<<<.....<<<<<......>>>>>................<<<<<<<<<<.......>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))]......((((((..(((..>>>>>>.)))))))))..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>........<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>>>.>.....<<<<<<<....>>>.>>>>....}}..}}}.]]]]].....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<.}}}..>>>>..>>.>>...>>>>...>>>><<<<....<<<<<...........>>>>>....>>>>.>>>...>.>>>>>>.....<<<<<<<.....<<<.....<<.........<<<<<..<<<<..>>>>.>>>>>........>>....<<...<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>...>>..............>>>....>>>>>>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<....<<<<<......>>>>>...>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..(((((((((((.....)))))).))))....))))....((((((.((.....(((((((.(......((((((((..({((((......)))))....[[(...).(((....}]])))...).)))))))..))))))).)...).)))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.........(((((.........(((((((((((...(((..(..((((.(....(((((.((....(.......).))))))).))))).).....))).)))))))))))..........))).)).....((((((((.((((.(((((.(((....(...(.((((.((.........((.(..).))..........)).))))).........).)))...))))).))))....................(((.(...((((......(.....)....))).)...(.((..(.(..(((((((((.(.(((.(((((...((........))...))))).))..)).))))))).))....)..)...)).).........(((.(..........)))).........).)))......))).)))))....)))...)))))))).[((((........))))((((((....(((((((((((((..(((..(((((........)))).)...)))...((....))...(((((..........)))))..(((((...(((..((......[...[..))..)))....))))).(((((((((.((((......))))))))))).))....)))))))))))))..((.(...((((((.....(((((((((..((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))....))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((............(.((((((....(((....(((..(.(((.......................))).)..)))..)).)....))))))...(((((((((........)))))))))....)...)))))))..))..((((.(((((.....))))).))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.(((((((((......{.(((.(....................................(......).....))))....))))))))))))..........]]].)....))))))))))...)))))))((((((.(((..........].....]......................................................)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((...((((((...((.....)).))))))....[[(((.((...((....(((....))).............(.((.............)).)........))....))...(((((........)))))]]((((....(((.(....(...((....))...)...((((....)))...(...((((((...(((((((((((((((((((((((..{{{..))))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....(((((((.......))))))))))).).))))))))))))(...)....))))))...)).........)..))).)))).)))..)).....((......)).)))).((((.....))))..)))....((((.....(((((((.((..(....(.......(((((....(.[..).....)))))((.(((((((((((........................)))))..)))))).))(...).......(((((((((.>.((.........))...(((((((....((((.....))))......))))))).].(((.(((..((((((.....(......((((....))))......)..))))..)))))...........................((..........(((((.......)))))..)..)....)))....)).))))))).)..))).)))))))..))))))....)).{..(((((.....]}.)))))....(((((..(((.(.......((((.((((((..(((((.(((((((((.(((((.().)))))...(((((.....((((.....(..............)................((((.(((.(........)))).))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(.(((..((((....{..))))..))))(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}....))))..)))))).......((.(.(.((((((...((.......))...))))))...)).).)........((((.((((((..(.(.(((((......)))))...).).(((.(.....).))).....)))))..)...))).).....(((((((....))).))))..a..)..))).))))).....((((((.(..(((..(.(((((......(....).....))))).)((((....((((....((.(((((((}}}.)))))..)).))...))))...)))).((((...((((.....}.......))))...))))..)))...).)))))).....((((((...(..(((.....((..........((((...(......)..)))).........))....(....(((....(((..(((((((......))))))).)))...)))....)..............)))...).))))))(((((.(..(.......)..)....((.(((((((.((.....((((.(..(((((......)))))..)))))....))....)))).))).))..))))).. human 80S ribosome bound by a SKI2-exosome complex; 28S ribosomal RNA 9g8m L7 120 3.3 RF00001 39385025 0003735 0005840 9606 gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcuu <<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>>.. (((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....))))))))))))))).. human 80S ribosome bound by a SKI2-exosome complex; 5S ribosomal RNA 9g8m L8 156 3.3 RF00002,RF02540 39385025 0003735 0005840 9606 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuucgaacgcacuugcggccccggguuccucccggggcuacgccugucugagcgucgcu .........................................<<<<<<.<<.....>>>.....(.<<<......>>.............>>>..)...>>>....<<....>><<<<<<<<.......>>>>>>>>.................... .........................................((((((.[[....[)))...].(.(((......]].............)))..)...)))....((....))((((((((.......)))))))).................... human 80S ribosome bound by a SKI2-exosome complex; 5.8S ribosomal RNA 9g8o S2 1739 3.4 RF01960,RF02542,RF01959,RF00177 39385025 0003735 0005840 9606 uaccugguugauccugccaguagcauaugcuugucucaaagauuaagccaugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucauuaaaucaguuaugguuccuuuggucgcucgcuccucucccacuuggauaacugugguaauucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgccccccguggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccacgggugacggggaaucaggguucgauuccggagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuuccgcgaggauccauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcgggcguccccgccgccucucggccggggcccgaagcauuuacuuugaaaaaauuagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccucacccggcccggacacggacaggauugacagauugauagcucuuucucgauuccgugggugguggugcauggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgaccccgcggucggcgucccccaacuucuuagagggacaaguggcguucagccacccgagauugagcaauaacaggucugugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcaggcgcggguaacccguugaaccccauucgugauggggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggggucggcccacggcccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua ...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.<<<..<<....<<....<<..........>>...>>.>>......<<........<<<.<....<<....<<<....................<<.....<<.<<.......>>.>>......>>.........<<<<...<<<<<......>>>>>...>>>><...<<<<<...<......>..>>>>>........>..<<<<.<<<<......>>>>>>>>....>>>...>>..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>...<<....>>.....>>>>>>.........<<<....<<<.....>>>..>>>..>...>>.>.....<<.<<<<<...............>>>>>..>>......<<..<...........>..>>.........<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<<.<<................................................<<<<<<.<.......<<...<.......>.<<<<.......>>>>...>>......>.>>>..>>>.......<<.<..<<.<<<<...............>>>>.>>..>>>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.........>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<........>>..........<<<<<.<....<<<<<<.......<<.<<<........>>>.>>.....>>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<<<<<<<....>>>>.>>>>.....>>>>..>>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<....>>>>.>>>....>.........>>>.>>......<...<.<<<<<..........>>>>>>....>.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<.<..........................>....>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>......... ...((((..[.[[[..))))(((.((.(((...(.((..((.....(((.(((..((....((.....(..........)....))[))......(((.......(((.(.(..((....((((....................(.....((..((.....))..))......)............((...((((........))))...))......(((((...(......)..)))))...........((((.(.((......)).)))))..).)))...))).).))).(((....(((....(((((((.........))))))))))......)))...(((.((((....))))....)))))).((.(((..........))).)).(.((....)).)...)))))).).....(.(((...((((.]...))).))))).)...)).).....((.((..(...............)..))..))....(.....(...........)..........)..((((([[......((((.....((..]])).......)))).)))))..))).)).)))..[......(.([[...(.(.((...(((..(................................................((((((.(.......((..((.......)).(((.......)))....))......).)))..))).......((.(..(....((...............))....).).))....)....(((..(...(...((((..((..((((.(((...((........))......))).))))..)).......((....))...))))..)...)...))..))))...)).)....((((((........((((.........)))).....))))))......{...(((.((.(((..(.((((((.(((........))))))))).)..)))...((..]]))...))...].))))).).(((......((((....))))....)))...]]].]((((..(((((((...(..(((((..(((.((((((......((........))..........(((((.(....(((((.....(..((.(((........))).))....).)))))...((.(((...(.((((((....(((.(((((....)))..(.((......)))...)).)))....(((...(....(((..(((((((((((((.).)))).)))).....))))..)))...).....(((((.....)))))........)))....))).))).....).))))).....).)))))...)).)))).))).(...((.(((........(.......(((.((((....)))).)))....).........))).))......(.....(((((..........))))).....)..)..))))).....((((((((.......))))))))......)....))))))).)).))..(.(..((.(..((((.((..(..(((.((..(((..((((.((...((.(...................................).))...)).))))..)))..)).))).)..)).))))...).))...)..)..(((((((((....)))))))))}........ human 40S ribosome bound by a SKI238-exosome complex; 18S ribosomal RNA 9g9c R 35 2.72 39817514 888064 acgagaacaugcgcgacauuccgaagaacgcugaa ................................... ................................... CryoEM structure of Enterococcus italicus Csm-crRNA-CTR (3.2) complex; RNA (32-MER) 9g9c T 32 2.72 39817514 2697049 uucagcguucuucggaaugucgcgcauuggca ................................ ................................ CryoEM structure of Enterococcus italicus Csm-crRNA-CTR (3.2) complex; RNA (32-MER) 9g9d R 38 2.9 39817514 888064 acgagaacaugcgcgacauuccgaagaacgcugaagcg ...................................... ...................................... CryoEM structure of Enterococcus italicus Csm-crRNA-CTR (4.3) complex; RNA (35-MER) 9g9d T 35 2.9 39817514 2697049 cgcuucagcguucuucggaaugucgcgcauuggca ................................... ................................... CryoEM structure of Enterococcus italicus Csm-crRNA-CTR (4.3) complex; RNA (35-MER) 9g9f R 35 2.93 39817514 888064 acgagaacaugcgcgacauuccgaagaacgcugaa ................................... ................................... CryoEM structure of Enterococcus italicus Csm-crRNA-CTR complex bound to AMPNPP; crRNA 9g9f T 32 2.93 39817514 2697049 uucagcguucuucggaaugucgcgcauuggca ................................ ................................ CryoEM structure of Enterococcus italicus Csm-crRNA-CTR complex bound to AMPNPP; CTR 9g9g R 38 3.38 39817514 888064 acgagaacaugcgcgacauuccgaagaacgcugaagcg ...................................... ...................................... CryoEM structure of Enterococcus italicus Csm-crRNA-CTR1 complex (4.3) bound to AMPNPP; RNA (35-MER) 9g9g T 35 3.38 39817514 2697049 cgcuucagcguucuucggaaugucgcgcauuggca ................................... ................................... CryoEM structure of Enterococcus italicus Csm-crRNA-CTR1 complex (4.3) bound to AMPNPP; CTR 9g9h R 30 2.99 39817514 888064 acgagaacaugcgcgacauuccgaagaacg .............................. .............................. CryoEM structure of Enterococcus italicus Csm-crRNA-CTR1 complex bound to pNppA3 and AMPNPP; crRNA 9g9h T 28 2.99 39817514 2697049 gcguucuucggaaugucgcgcauuggca ............................ ............................ CryoEM structure of Enterococcus italicus Csm-crRNA-CTR1 complex bound to pNppA3 and AMPNPP; CTR 9g9i R 25 3.31 39817514 888064 acgagaacaugcgcgacauuccgaa ......................... ......................... CryoEM structure of Enterococcus italicus Csm-crRNA-CTR2 complex bound to pNppA3 and AMPNPP; crRNA 9g9i T 17 3.31 39817514 2697049 ucggaaugucgcgcauu ................. ................. CryoEM structure of Enterococcus italicus Csm-crRNA-CTR2 complex bound to pNppA3 and AMPNPP; CTR 9g9k R 30 3.34 39817514 888064 acgagaacaugcgcgacauuccgaagaacg .............................. .............................. CryoEM structure of Enterococcus italicus Csm-crRNA-CTR2 complex (4.3) bound to AMPNPP; crRNA 9g9k T 22 3.34 39817514 2697049 cguucuucggaaugucgcgcau ...................... ...................... CryoEM structure of Enterococcus italicus Csm-crRNA-CTR2 complex (4.3) bound to AMPNPP; CTR 9gbw G 11 3.5 39809272 9606 auauccuuuuu ........... ........... Overall structure of the substrate-bound U11 snRNP; P120-5'SS 9gbw R 118 3.5 RF00548 39809272 0030627 0000395 0005692 9606 aaaaagggcuucugucgugaguggcacacguagggcaauugcucugcgugcggaaucgacaucaagagauuucggaagcauaauuuuuugguauuugggcagcuggucccggcgcccu .......<<<<<<<<<......>>>><<<<<<<<<<<..>>>>>>>>>>><<<<<<<..........>>>>>>>>>>>>.................<<<<.<<<<....>>>>>>>>. .......(((((((((......))))(((((((((((())))))))))))(((((((..........)))))))))))).................((((.((.((..)).)))))). Overall structure of the substrate-bound U11 snRNP; U11 snRNA 9gbz G 11 3.4 39809272 9606 auauccuuuuu ........... ........... 5'-lobe of the substrate-bound U11 snRNP; P120-5'SS 9gbz R 79 3.4 RF00548 39809272 0030627 0000395 0005692 9606 aaaaagggcuucugucgugaguggcacacguagggcaauugcucugcgugcggaaucgacaucaagagauuucggaagc .......<<<<<<<<<......>>>><<<<<<<<<<<..>>>>>>>>>>><<<<<<<..........>>>>>>>>>>>> .......(((((((((......))))(((((((.(((()))).)))))))(((((((..........)))))))))))) 5'-lobe of the substrate-bound U11 snRNP; U11 snRNA 9gft 0 1533 3.1 RF00177,RF01959,RF02542,RF01960 39922193 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggauc ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<......>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<.<....>>>>>.....<.....>...>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((((((......)))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((.(....).))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))...(((......((((....)))).....)))....(.(((((...(....(((.((((.......)))).))).....)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((....(........).......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(.(.(......)).).....(.....)...))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....(((((..((((..((....)).)))).)))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Structure of the HrpA-bound E. coli disome, Class I; 16S ribosomal RNA 9gft A 76 3.1 RF00005 39922193 0030533 562 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).(((((.......))))).....(..((..]....))..)))))))).... Structure of the HrpA-bound E. coli disome, Class I; A-site tRNA 9gft A3 77 3.1 RF00005 39922193 0030533 562 ggcuacguagcucaguugguuagagcacaucacucauaaugauggggucacagguucgaaucccgucguagccacca <<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<.<<.......>>.>>>>>>>>>.... (((((((..((((.....[...)))).((.((.......)).)).....((.(...].....).))))))))).... Structure of the HrpA-bound E. coli disome, Class I; A-site tRNA 9gft AA 1539 3.1 RF01959,RF00177,RF02542,RF01960 39922193 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<<....>>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<<....>>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<....<.<<<<<<.....>>>>>>.>..>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>.>>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<.<....>>>>>.....<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((((((......)))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((.(....).))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(.(((....)))..))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....(((.((((.......)))).))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((.(.((((((((((......((((((.....))))))....))))))))..))).)))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((....(..((......))..)....(......)...)))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.(((...((....))..)))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Structure of the HrpA-bound E. coli disome, Class I; 16S ribosomal RNA 9gft AU 76 3.1 RF00005,RF00023 URS00001C39A4_562 39922193 0030533 0006401,0006412 562 ggggcuauagcucagcugggagagcgcuugcauggcaugcaagaggucagcgguucgaucccgcuuagcuccacca .<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((....[...)))).(((((.......))))).....(((((..]....)))))))))))..... Structure of the HrpA-bound E. coli disome, Class I; P-site tRNA 9gft AV 2897 3.1 RF02540,RF02541,RF02543,RF00002 39922193 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu .<<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>...>.>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<......<<...<<<.<<<<...<<.<<<.>>>..>>...>>>>.>>>..>>.......>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<..<<<..<<...........>>..>>>........<<<......>>>...>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<..<<....>>..>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<....<....>.....>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<..<<....>>...>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<..<<<...........<<<<<..<<........<<<<<<<....>>>>>>>.....>>............>>>>>..>>>..>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>.. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((.(((...(((]]]..].))).......))).))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......((((((((((.((.(((....((((......)))).[[(...).(((.....]])))...)))...)).))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((...((((......))))...)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((.(((.)))..))...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(.(.....{..(((..(((..((...........))..))).....(..(((......))))..)))....).)..))))).))...........]]].)...))))))))))...)))))))(((((..((....))..)))))....))))))(.(((((...(((......((.(((((....))))).))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..(((((.((((((...{{{.).))))).((..((((...(((.((((((((.((.....))))))))))...)))..[))))...))(...((((....))))....))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))(((((......(((...((((....]))))...)))....)))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........((.((..((....))...)).))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((.((((((..(.(...........(((((..(((.......(((.((......)).)))....)))............)))))..)..).)))))).))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Structure of the HrpA-bound E. coli disome, Class I; 23S RNA 9gft AW 118 3.1 RF00001 39922193 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (((((((.(.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((.(((((...))))).)).......))...).))))))). Structure of the HrpA-bound E. coli disome, Class I; 5S ribosomal RNA 9gft M 75 3.1 RF00005 39922193 0030533 562 ugggguaucgccaagcgguaaggcaccggauucugauuccggcauuccgagguucgaauccucguaccccagcca <<<<<<<..<<<.........>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..(((.....[...))).(((((.......))))).....(((((..]....)))))))))))).... Structure of the HrpA-bound E. coli disome, Class I; P-site tRNA 9gft N 2897 3.1 RF02540,RF02541,RF02543,RF00002 39922193 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>...>.>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<.>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<<..<<<<.......>>>>..>>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>.>........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.......<<<<<<.<<....>>..>>>>>>.......>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<<<<<..<<.......<<<<<<<<....>>>>>>>>....>>............>>>>>...>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>.(<<...<<<<<<<...<<<<<<.......>>>>>>.....<<)..(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......((((.((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))).))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..))))...(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((.(((.)))..))...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{..((((.(((..(((.........)))..))).....(..(((......)))).))))....)))..))))).))...........]]].)...))))))))))...)))))))(((((((((....)))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(...((((....))))....))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...(((((..)]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).[..(((((......].)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((.(.(.(((............(((.(..((........((((((......)))))).....))............).)))...))).).).)))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Structure of the HrpA-bound E. coli disome, Class I; 23S RNA 9gft O 118 3.1 RF00001 39922193 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))). Structure of the HrpA-bound E. coli disome, Class I; 5S ribosomal RNA 9gft w 57 3.1 39922193 663 ugccauguacgucgcacucaauagucaguuuucuguuuuuuuuuuuuuuuuuuuuuu ......................................................... ......................................................... Structure of the HrpA-bound E. coli disome, Class I; messenger RNA 9ggr 0 1533 3.2 RF00177,RF01959,RF02542,RF01960 39922193 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggauc ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<<....>>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<.<......>>>>.....<.....>...>>>>>.>>.<<<.<<<..<<<<<<.<.....<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.....>...>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((.(((((......)))))..)))))..)))))......(((......(((((((..((...(.(((((.(.((.....((((.(....).))))......)).).....(((....)))....((((((..((....)))))))).))))).)..)).)))))))(((....(((..((((((.(.......).)))))))))......)))..((((((((....))))...))))))).(((((.(.........)))))).((((....))))...)))))).).....(.(((...(.(((....)))..))))).)).))))))...(((......((((....)))).....)))....(.(((((...(....(((.((((.......)))).))).....)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((.(.((((((((((......((((((.....))))))....))))))))..))).)))))..(((((((((...((((((((....(((((((....(........).......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((...(.(.(......)).).....(.....)...))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.(((...((....))..)))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}.... Structure of the HrpA-bound E. coli disome, Class II; 16S ribosomal RNA 9ggr A 76 3.2 RF00005 39922193 0030533 562 gcccggauagcucagucgguagagcaggggauugaaaauccccguguccuugguucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).(((((.......))))).....(..((..]....))..)))))))).... Structure of the HrpA-bound E. coli disome, Class II; A-site tRNA 9ggr A3 77 3.2 RF00005 39922193 0030533 562 ggcuacguagcucaguugguuagagcacaucacucauaaugauggggucacagguucgaaucccgucguagccacca <<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<.<<.......>>.>>>>>>>>>.... (((((((..((((.....[...)))).((.(.........).)).....((.((..]....)).))))))))).... Structure of the HrpA-bound E. coli disome, Class II; A-site tRNA 9ggr AA 1539 3.2 RF01959,RF00177,RF02542,RF01960 39922193 0003735 0005840 562 aauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccgcgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggggaaccugcgguuggaucaccuccu .......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<<..<<<<<<<<<......>>>>>>.>>>>>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<<..>>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<.......<<<....>>>......>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<.<......>>>>.....<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>............ .......((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((((((((......)))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((.(....).))))......)).).....(((....)))....(((.((..((....)))).))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((.(...((........))......).)))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].]((((..(((((((.((..(((((..((((((((((......((........))..........(((((((..(...((((((.....(.((......))..)....(......)...)))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....(((..(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)...))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...))))))).)).))..(.(..((.(.((((.(((..((((((((((((....(((.((.(((...((....))..))))).)))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}........... Structure of the HrpA-bound E. coli disome, Class II; 16S ribosomal RNA 9ggr AU 76 3.2 RF00005,RF00023 URS00001C39A4_562 39922193 0030533 0006401,0006412 562 ggggcuauagcucagcugggagagcgcuugcauggcaugcaagaggucagcgguucgaucccgcuuagcuccacca .<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((....[...)))).(((((.......))))).....(((((..]....)))))))))))..... Structure of the HrpA-bound E. coli disome, Class II; P-site tRNA 9ggr AV 2897 3.2 RF02540,RF02541,RF02543,RF00002 39922193 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu .<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<...........<<<.<<<<...<<.<<<.>>>..>>...>>>>.>>>...........>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<..<<<..<<...........>>..>>>........<<<......>>>...>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<..<<....>>..>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<....<....>.....>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<..<<....>>...>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<..<<<...........<<<<<..<<<........<<<<<<....>>>>>>.....>>>............>>>>>..>>>..>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>.. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......((((((((((.((.(((....((((......)))).[[(...).(((.....]])))...)))...)).))))))))))...))))...)....((((((((..[......))))))))......((.((].[[[[)).))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..(((.......))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((..((.))...))...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..((.((..(.(.....{..((((.(((..((...........))..))).....(..(((......)))).))))....).)..)).)).))...........]]].)...))))))))))...)))))))(((((..((....))..)))))....))))))(.(((((...(((.......(.(((((....))))).)....)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((.(...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...(((.((((((((.((.....))))))))))...)))..[))))...))(...((((....))))....))))))...)))...))))(..).....))))...).....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((..((.(((((.((((.((((((..(.(...........(((((...((.......((((((......))))))....)).............)))))..)..).)))))).))))...(((.((((((.....)))))))))....))))).))...)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..)))))).......((((.(.((((((...((.......))...))))))...)))).)........((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Structure of the HrpA-bound E. coli disome, Class II; 23S ribosomal RNA 9ggr AW 118 3.2 RF00001 39922193 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......(.((((((...)))))).).......))...))))))))). Structure of the HrpA-bound E. coli disome, Class II; 5S ribosomal RNA 9ggr M 75 3.2 RF00005 39922193 0030533 562 ugggguaucgccaagcgguaaggcaccggauucugauuccggcauuccgagguucgaauccucguaccccagcca <<<<<<<..<<<.........>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..(((.....[...))).(((((.......))))).....(((((..]....)))))))))))).... Structure of the HrpA-bound E. coli disome, Class II; P-site tRNA 9ggr N 2897 3.2 RF02540,RF02541,RF02543,RF00002 39922193 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>...>.>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<.>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<<..<<<<.......>>>>..>>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<<.<<....>>..>>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<<<<<..<<.......<<<<<<<<....>>>>>>>>....>>............>>>>>...>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>.(<<...<<<<<<<...<<<<<<.......>>>>>>.....<<)..(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......((((((((((.((.(((...(((((......)))))[[(...).(((.....]])))...)))...)).))))))))))...))))...)....((((((((..[......))))))))......((.((].[[[[)).))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..)))).[.(.(........).).((((((....(((((((((((((..((....((.....))....))...((....))..(((.......))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....)))))..(((((((..((((((((((.....(((...(((.((((...((((((.)))).))...)))).)))..)).).....)))))).)))..)))))))).....((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(((..(((.........)))..))).....(..(((......)))).)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((.((((....)))).))))....))))))(.(((((...(((.......((.((((....)))).))....)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...(.((....((((..(((..(((((.((((((...{{{.).))))).((...(((...((((((((((((.((.....))))))))))..))))..[)))....))(...((((....))))....))))))...)))...))))(..).....)).)...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((......((...(((((..)]))))...))....))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........((.((..((....))...)).))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((.(.(.(((............(((((..((........(((((((....))))))).....))............)))))...))).).).)))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....((.((((.((..]]]]..)))))).)).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).).....(((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).))....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((.(((}}}.))).))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Structure of the HrpA-bound E. coli disome, Class II; 23S ribosomal RNA 9ggr O 118 3.2 RF00001 39922193 0003735 0005840 562 gccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>. (((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))). Structure of the HrpA-bound E. coli disome, Class II; 5S ribosomal RNA 9ggr w 57 3.2 39922193 663 ugccauguacgucgcacucaauagucaguuuucuguuuuuuuuuuuuuuuuuuuuuu ......................................................... ......................................................... Structure of the HrpA-bound E. coli disome, Class II; messenger RNA 9gmo A 3394 2.59 RF02543,RF02540,RF02541 38746087 0003735 0005840 9606 cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuagucagcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaacagggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacauguggcguacggaagacccgcuccccggcgcggggggcccaaguccuucugaucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagngngaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggaggauucaacccggcggcggguccggccgugcccggcggaucuggaccgucccccggcgaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcucggccgaguguuacagcccccccggcagcagcacucgccgaaucccggggccgagggagcgagaccgucgccgcgcucuccccccugggggggccgggccaccccucccacggcgcgaccgcucggggcggacuguccccagugcgccccgggcgggucgcgccgucgggcccggggggccacgcgcgcguccccggggacggcggagcgagcgcacggggucggcggcgacgucggcuacccacccgacccnucuugnnacncggaccaaggagunuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaaugaaggugaaggccggcgccggccgaggugggaucccgaggccucuccaguccgccgagggcgcaccaccggcccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuaggacccnanagauggugancuaugccugggcagggcgaagccagaggaaacucugguggagguccguagcgguccugacgugcaaaucggucguccgaccuggguauagnggcgaaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcuggcgcucucgcagacccgacacgcaguuuuauccgguaaagcgaaugauuagagguaccuauucucaaacuuuaaauggguaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccuagugggccacuuuugguaagcngaacuggcgnugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauaaucaacuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccggcagucgagaguggacgggaccgcggacgcuacgccgcgacgaguaggagggccgcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggugcagaunuuggugguagunnnaaauauucaaacgagaacuuugaaggccgaaguggngaaggguuccaugngaacagnanuugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccguugcccucggccgaucgaaagggagucggguucagauccccgaauccggagcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucgcggcggcggcguccggugagcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccguacccnuauccgcagcaggucuncaaggugaacngccucuggnauguuggaacaanguagguaagggaagucggcaagcnggauccguaacuucnggauaaggauuggcucuaagggcugcagccgacuuagaacuggugcggaccaggngaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugugauuucugccnagugcucugaaugucanagugangaaauucaaugaagcgcggnuaaacggcgggagcucucuuaagguagcnaanugccucnucaucuaauuagugangcgcaugaanggaugancgagnuucccacugunccuaccuacuauccagcgaaaccacngncaagggaacgggcuuggnggaaucagcggngaaagaagacccuguugagcuugacncuagucuggcacggugaanagacguuuuuucacugacccggugaggcgggggcuucuggcgccaagcgcccggccgcggccgggcgcgacccgcuccggggacagugccagguggggaguuugacugnggcgguacaccugucaaacgguancgcaggnnuccuaaggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuugaucuugauuuucagnacgaauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagcaggangugucagaaaaguuaccacagngauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuungaugucggnucuuccuaucauugugaagcagaauucaccaagcguungaunnuucacccacuaauagggaacgugngcugggnuuagancgucgugagacagguuaguuuuacccuacugaugnuguguuguugccaugguanuccugcucaguacgagaggaaccgcagnuncanacauuugguguaunugcuuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccgcggagccucgguuggccucggauagccgguuccggugcggagugcccuucguccugggaaacggggcgcggccggaaaggcggccgcccccucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgaccugcuugggucgggguuucguacguagcagagcagcgcugcgaucuauugaaagucagcccucgacacaaggguuugu .........................<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>.....>>>>>..<<<<<<<<<<...<<<<<<<<.<<<<<<<<....<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>>>...>>>>>>>>..>>>>>>>>>>.......<<<<<<<........>>>>>>>.....<<<<<..((((((>>>>>..>>>..................................<<....>>...............<<<......>>>..................................<<<<<<<<..<<<.<<...<<<<<<<<.<<<.....<<<<<<<<<<<..<<<<<<<.....<<<<<.<<..>>>>>>>...>>>>...>>>>>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<<<<<<<<<<<<<<<<<...<<..<<<..<.<<<<......<<<<<..>>>>>.......>>>>.>.>>>........>>>>>>..>>>>>>>>>>>...................<<<<<<.<<<<<<..>>>>>>.<<<<<<.<<<<.<<<<<<<<<<<<<<<<<<<<<<<<.<<<<....>>>>.>>>>>>>>>>>.>>>>>>>>>>.>>>...>>>>>>>>.>>..<<<<<<<<..>>>>>>.>>....>>>>>>.....>>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<....>>...<<<<<<..>>>>>>..<<<<<...<<<..<<<...[[[.((((>>>..>>>....>>>>>.<<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...............<<<.<<<<<<<<<...<<<....<<<..<.<<<..>>>.>..>>>..>>.>...>>>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>>>>>>.>>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<.>>>>>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<..........)))).]]].............>>>>>>>>>....>>>>>>...<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<<<<<<..>>>>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<.<<<<<..<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..[[[..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<<<<<<....>>>>>>>>>>>...>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<...............<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<..>>>>..>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.>>>>..>>>>><<<<..>>>>........<...........<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<<<..>>>>>>>>>...<<<<<.....<<<<...............<<<<<<<<<<..>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>><<<<....>>>>>>)))].....<<<<<<<..<<<..)))))).>>>>>>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.<<<.<.....>.>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<....<<<<....<<.<<<<<<<]]].>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>.....<<<<<<<.<<..<<<<....<<<........<<<<<..>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>..............>>>>..>>>>>>>>><<<<<.<.............>..<<.<<<<<<<.<<.....<<<<....<<<<..>>>>...>>>>....>>....>>>>.>>>.>>..>>>>>.. .........................(((((......(...[..).......)))).).........((....))...((((......((.]...)).....))))...((((...(((..(((((((((((.....)))))).))))....))))....(((((((((....((((((((.((((((((..({((((......)))))....[[(...).(((....}]])))...).)))))))...))))))))...)))))))))..)....(((((((........))))))).....(((((..[[[[[[)))))..)))..................................((....))............(..((((....))))............).....................((((((((..(((.((...((((((((.(((.....(((((((((.(..((.((((.(...(((((.((())))))))..)))))....))).)))))))))......))).))).)))))...(((((((((((((((((((((((...((..(((..(.((((.......((((()))))........)))).).)))........))))))..)))))))))))......{............((((((.((((((())))))).((((((.((((.((((((((((((((((((((((((.((((....)))).))))))))))).)))))))))).)))...)))))))).))..((((((((())))))).))....)))))).....))).)))))...)))))...)))))))).[((((........))))((((((....(((((((((((((..(((..((((..........)))..)..)))...((....))...((((((()))))))..(((((...(((..(((...[[[.[[[[)))..)))....))))).(((((((((.(((((...).))))))))))).))....)))))))))))))..((.(...((((((.....((((((((((.((((...(((((((....)))))))...)<)))...(((..((.((.......A)))).)))..).))))))))).(.((.......))...)..))))))......).))..((((((....(.(((....))).)((.(((((((...............(((.((((((((.....((.....((....(((..)))....))...))......))))))...(((((((((.(......))))))))))....))))))))))))..))..((((..(.((.....)).)..))))....(((......)))...(((((((...((([[[...(.(.(((((......(..........(((.((((((((((.)))))))))))))..........]]].)....))))))))))...)))))))((((((.(((........}.]]]].]]](...)........)))))))))....)))))).(.((((((((.((......((((.((((....))))))))...))))))))))..).....))))))((.....((.....((((((.......)))))).(((.....((((..((..(((((((...((.....)).))))))....[[(((.((...(.....(((....)))...(.)....((.((((((((())))))))))).......)....))...(((((........)))))]]((((.(((((...(((((((....)))))))..((((....)))...(...((((((...((((((((((((((((((((((...{{{...)))))....(((((.((((.((((.....(((.....))).....))))))))..))))).....((((((((.).))))))))))).).))))))))))))(...)....))))))...)).........)).))).)))).))).))).....((......)).)))).((((.....))))..)))....(((......(.((((..((..(....(.......(((((....(.[..).....)))))((.((((((((((()))))..)))))).))(...).......(((((((((.>.(...........)...(((((((....((((.....))))......))))))).].(.(.(((..((((((.....(......((.(....).))......)..))))..)))))(.(.().).)........((..........(((((.......)))))..)..)....).)....)).))))))).)..)))..)))).)...)))))....)).{..((.((.....]}.)).))....(((((..(((.((......((((.(((((...(((((.(((((((((.(((((.(((()))).)))))...(((((.....((((...............((((((((((()))))))))))..))))..)))))....)))))))))..)))))..(((......[)).)((((((..........]))))))([((...(((((((.(.((((((.......))))))...).((]..[[[))....))))))).(..((....((....{..))....)).)(((....))).))]]].......((((((..(((..]]]]]].)))))))))....)}.....)))..)))))).......(....(.((((.(...((.......))...).))))...)....)........((((.((((((..(.(.(.(((......))).)...).)..((.(.....).))......)))))..)...))).)......((((((....))).)))...a.))..))).))))).....(.((.(.(..(((..(.(((((......(....).....))))).)(((.....((((....((.(((((((}}}.)))))..)).))...))))....))).((((...((((.............))))...))))..)))...).).)).).....((((((..((..((((.(..(((........(((((..))))).......)))...(((...(((....((((.(((((((......)))))))))))...)))...)))...........)..))))..)).))))))(((((....(.......).....((.(((((((.((.....(.((.(..((((()))))..))).)....))....)))).))).))..))))).. eIF6-bound pre-60S large ribosomal subunit incorporating mutant uL16; 28S rRNA 9gmo B 118 2.59 RF00001 38746087 0003735 0005840 9606 ucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaagcuaagcagggucgggccugguuaguacuuggaugggagaccgccugggaauaccgggugcuguaggcu <<<<<<<<....<<<<<<<<.....<<<<<..............>>>..>>....>>>>>>.>><<<<<<<.....<<.<<..<<....>>.>>.>>....>>>>>>>>>>>>>>>.. ((((((((....((((((((.....((((((...(....)...))))..))....)))))).))((((((......((.((..((....)).)).)).....)))))))))))))).. eIF6-bound pre-60S large ribosomal subunit incorporating mutant uL16; 5S rRNA 9gmo C 148 2.59 RF00002 URS0000005270_9606 38746087 0003735 0005840 9606 cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagcuagcugcgagaauuaaugugaauuncaggacaugaucaucgacacuucgaacgcacuugcggccccgggcccggggcuacgccugucugagcgucgcu .........................................<<<<<<<<<....>>>>.....<.<<<......>>..........>>>..>...>>>....<<....>><<<<<<<<..>>>>>>>>.................... .........................................((((((.[[.....))).....(.(((......]]..........)))..)...)))....((....))((((((((())))))))).................... eIF6-bound pre-60S large ribosomal subunit incorporating mutant uL16; 5.8S rRNA 9gmx T 52 2.82 39627193 9606 caggauggccgaguggaaggcaauggacguccgcguggguucgaaccccacu .......<<<........>>>...<<<..>>>..<<<<<.......>>>>>. ....(..(((.....[..)))...(((())))..(((((..]....)))))) SLFN11 WT dimer bound to tRNA-Leu-TAA (post-cleavage state); RNA (76-MER) 9gr1 A 1513 3.17 RF00177,RF01959,RF02542,RF01960 39607923 0003735 0005840 469008 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugccggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugcgaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggaucaccuccuuu ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<<..>>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<<..>>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<..>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>.......>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.............. ........((((..[.[[...)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((.)))))..)))))......(((......(((((((..((...(.(((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).))))).)..)).)))))))(((....((...((((((((.......)))))))).))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..(((.......((((....))))......)))..((.(((((...(...(((((((((.......)))))))).)...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..(((((((((((())))))))))))...((..]])).....)))))))))).(((......((((....))))....)))....]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))...()..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}............. E. coli 70S-TEC complex in delivery state; 16S ribosomal RNA 9gr1 X 13 3.17 39607923 32630 auucauguucaca ............. ............. E. coli 70S-TEC complex in delivery state; mRNA in ribosome channel 9gr1 Z 76 3.17 RF00005 39607923 0030533 562 gcccgganagcucagncggnagagcaggggauugaanauccccgunnccuuggnucgauuccgaguccgggcacca <<<<<<<..<<<<........>>>>.<<<<<<.....>>>>>>.....<<<<<.......>>>>>>>>>>>>.... (((((((..((((.....[..)))).((((.........)))).....(((((..]....)))))))))))).... E. coli 70S-TEC complex in delivery state; Phe-NH-tRNA(Phe) A-site 9gr1 a 2748 3.17 RF02540,RF02541,RF02543,RF00002 URS00026177A6_37762 39607923 0003735 0005840 469008 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacagcugugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaucccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagcgucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcgcguuguuggguaggggagcguucuguaagccugugaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcggcgcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauauguucuaacguuggccccugaucgggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgngganaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacuccuugagaguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<..>>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<..>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<..>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<...<...<<<<<..<<<.>>>...>>>>>..>....>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<..>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((())))))..)))).[.(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((.......<))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((((((.....))))).))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(())...)))..))))).))...........]]].)...))))))))))...)))))))((((((((()))))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..(((.)))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((())))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).).....((.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..))....(..((((....))).)..)..>.))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.(((((.....)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). E. coli 70S-TEC complex in delivery state; 23S ribosomal RNA 9gr1 b 119 3.17 RF00001 39607923 0003735 0005840 469008 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>> ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))) E. coli 70S-TEC complex in delivery state; 5S ribosomal RNA 9gr1 4 10 3.17 39607923 32630 gcaaggagga .......... .......... E. coli 70S-TEC complex in delivery state; mRNA in SD-aSD duplex 9gr1 Y 77 3.17 RF00005 39607923 0030533 562 cgcggggnggagcagccuggnagcucgucgggnucauaacccgaagaucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... E. coli 70S-TEC complex in delivery state; tRNA(fmet) P-site 9gup A 1539 2.8 RF00177,RF01959,RF02542,RF01960 39607923 0003735 0005840 83333 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggguaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacugggguggucgnaacaagguaaccguaggngnnccugcgguuggaucaccuccuu ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<<....>>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<<..>>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>>.>>...>.....<<<<<<<<<....>>>>>>>>>............. ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((((....))))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....(((.((((.......)))).))).....)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[.....((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))).))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))...((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((...(((((((((((....((((((.((((..((....)).))))))))))...)))))))))))...))).))))).))...)..)..(((((((((....)))))))))}............ 30S mRNA delivery complex (open head); 16S ribosomal RNA 9gup X 17 2.8 39607923 32630 aaggagguauucauguu ................. ................. 30S mRNA delivery complex (open head); mRNA 9guq A 1539 3.1 RF00177,RF01959,RF02542,RF01960 39607923 0003735 0005840 83333 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggguaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacugggguggucgnaacaagguaaccguaggngnnccugcgguuggaucaccuccuu ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<<....>>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>>.>>...>.....<<<<<<<<<....>>>>>>>>>............. ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((.((((((....))))))..)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))...((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((.(.(((((....((((((.((((..((....)).))))))))))...))))).).))))..))).))))).))...)..)..(((((((((....)))))))))}............ 30S PIC (Pre-Initiation complex); 16S ribosomal RNA 9guq W 77 3.1 RF00005 39607923 0030533 83333 cgcggggnggagcagccuggnagcucgucgggnucauaacccgaagaucgucggnucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... 30S PIC (Pre-Initiation complex); tRNA(fmet) P-site 9guq X 20 3.1 39607923 32630 aggaggucauguucacauac .................... .................... 30S PIC (Pre-Initiation complex); mRNA 9gus A 1539 3.5 RF00177,RF01959,RF02542,RF01960 39607923 0003735 0005840 83333 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggguaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacugggguggucgnaacaagguaaccguaggngnnccugcgguuggaucaccuccuu ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<<....>>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<.<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>.>>>>>..>>>.>>>>>.>>...>.....<<<<<<<<<....>>>>>>>>>............. ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((((....))))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))...........(([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))..(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((.(((....))).)))...((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..(((.(..(((((....((((((.((((..((....)).))))))))))...)))))..).)))..))).))))).))...)..)..(((((((((....)))))))))}............ 30S mRNA delivery complex TEC resolved (30S only); 16S ribosomal RNA 9gus X 18 3.5 39607923 32630 aaaggagguauucauguu .................. .................. 30S mRNA delivery complex TEC resolved (30S only); mRNA 9gut A 1539 2.8 RF00177,RF01959,RF02542,RF01960 39607923 0003735 0005840 83333 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggguaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacugggguggucgnaacaagguaaccguaggngnnccugcgguuggaucaccuccuu ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<<....>>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<<..>>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>>.>>...>.....<<<<<<<<<....>>>>>>>>>............. ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..(((.((((((....))))))..)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(..(.((((((((.......)))))))).)...)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))...((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))).))...)..)..(((((((((....)))))))))}............ 30S mRNA delivery complex (bS1 resolved); 16S ribosomal RNA 9gut X 17 2.8 39607923 32630 aaggagguauucauguu ................. ................. 30S mRNA delivery complex (bS1 resolved); mRNA 9guu A 1539 2.5 RF00177,RF01959,RF02542,RF01960 39607923 0003735 0005840 83333 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggguaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacugggguggucgnaacaagguaaccguaggngnnccugcgguuggaucaccuccuu ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<<....>>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>>.>>...>.....<<<<<<<<<....>>>>>>>>>............. ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((((....))))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(....((((((((.......)))))))).....)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))...((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((...((((.(((..(((.(.((((((....((((((.((((..((....)).))))))))))...)))))).).)))..))).))))..))...)..)..(((((((((....)))))))))}............ 30S mRNA delivery complex (consensus); 16S ribosomal RNA 9guu X 17 2.5 39607923 32630 aaggagguauucauguu ................. ................. 30S mRNA delivery complex (consensus); mRNA 9guv A 1539 3.0 RF00177,RF01959,RF02542,RF01960 39607923 0003735 0005840 83333 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggguaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacugggguggucgnaacaagguaaccguaggngnnccugcgguuggaucaccuccuu ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<<....>>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>>.>>...>.....<<<<<<<<<....>>>>>>>>>............. ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((((....))))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(..(.((((((((.......)))))))).)...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..))).)))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((((.(((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))...((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))).))...)..)..(((((((((....)))))))))}............ 30S mRNA delivery complex (closed-head); 16S ribosomal RNA 9guv X 17 3.0 39607923 32630 aaggagguauucauguu ................. ................. 30S mRNA delivery complex (closed-head); mRNA 9guw A 1526 3.1 RF00177,RF01959,RF02542,RF01960 39607923 0003735 0005840 83333 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggguaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagaagguaaccguaggngnnccugcgguuggaucaccuccu ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<<....>>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<...<<<<<....>>>>.>>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<...<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<<......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.......>.>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>.....<<....<<<<..<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>..>>>>......>><<<<<<<<<....>>>>>>>>>...>>>...... ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((.(((....))).))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(....((((((((.......)))))))).....)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))...]]].](((...(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((..(((((((....)))))))...((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....))))))))..)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))...........((((..((...(((.(((((((....((((((.((((..((....)).))))))))))...))))))).)))...))..))))........(((((((((....)))))))))}..)))...... 30S-TEC (TEC in expressome position) Inactive state 2; 16S ribosomal RNA 9guw X 22 3.1 39607923 32630 aggaggacacaaacggcgcgcg ...................... ...................... 30S-TEC (TEC in expressome position) Inactive state 2; mRNA 9gux A 1512 3.3 RF00177,RF01959,RF02542,RF01960 39607923 0003735 0005840 83333 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggguaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgcccgucacaccaugggaguggguugcaaaagaagccacuuugugauucaugacuggggugaagucguaacaagguaaccguaggngnnccugcgguuggaucaccuccuua ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<<....>>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<...<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<..<<<<<<<....>>>>>>>...<<....>>..>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>..<....<<.<<................<<<<<<<<<<<<.........>>>>>>>>>>>>............>>.>>....>...<<<<<<<<<....>>>>>>>>>...>>>........ ........((((..[.[[[..)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((((....))))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))..((.(((((...(...(((((((((.......)))))))).)...)....)))))....)).((((([[[...(((((.....((.]]])).......))))))))))..)))))))))...........(([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))..(((......((((....))))....)))...]]].](((..((((((((.((..(((((..((((((((((......((........))..........(((((((..(...(((((((..(((((((....)))))))...((....))..))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....((((.(((((((...((..(((.....)))))....)))))))..(..(((((.....))))).....)..)))).....).).)))...)).)))))....)))))))...)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))).(....((.((.........(.(((..((((.(((((((....()...))))))).))))..)))..)....)).))....)...(((((((((....)))))))))}..)))........ 30S-TEC (TEC in expressome position) Inactive state 1; 16S ribosomal RNA 9gux X 21 3.3 39607923 32630 aggaggacacaaacggcgcgc ..................... ..................... 30S-TEC (TEC in expressome position) Inactive state 1; mRNA 9h3q A 2569 4.02 RF02540,RF02541,RF02543,RF00002 39794318 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaaggguaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaaugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<<<<..>>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<...>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<....<<<.........>>>....>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<.<<....>>.>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><.............<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<..[..>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<.<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<....<<<<<<<<<<<<.<<.....>>>>>>>>>>.>>.>>....>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>.....>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..].......<<<<<<<...<......>...>>>>>>>............>.....<<<<<........>>>>>..<<<<<<<<.(((.........<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<.<<<<<...........<.<<<..<<.......<<..<<<......>>>..>>....>>............>>>.>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<.<<<.<.<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>...>...>>>..>....<<<<<<<....>>>.>>>>........)))>>>>>>>>....<<<<<<<...<<<.<..<<<<<<.....<....>....>>>>>>..<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>.>>.<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....(((((((..(((]]]..].)))......)))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((.(.(((...(((((......)))))[[......(((.....]])))...)))...).)))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((((..)))))))..))))...(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.(((....((((((......)))))).....)))...(((.(((((........))))))))..).))))))))).(.((.......))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...((.)..)...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{..((((.(........................).......(((......)))..))))....)))..))))).))...........]]].)...))))))))))...)))))))((((((.(......).))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(.............((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((...(((...(((....)))...)))...)))..(((((........)))))]](((.((((((.((...((((....((((..(((..(((((.((((((...{{..).))))).....((((...(.(.((((((((.((.....))))))))))..).)....)))).....(..(.(((....))))....))))))...)))...))))(..).....))))...)).....)))))).))).))).))).....((......)).)))).((((.....))))..))))..(.......(((((((..((......))..)))))))....).......)).[..(((((......].)))))..((((((((.(((..(......((((.((((((..(((((.((..(((((.((((((((((.(..((..............((............(..(((......)))..)...................)).....))...)))))))))))...(((.((((((.....)))))))))....)))))..))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..)))))).......((((.(.((((((...((.......))...))))))...)))).)........(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(.(((((....))).)).).....)..)))))))))))[....((((((...(((.(.(.(((((.....(....)....))))).).(((((...((((...(((((((((((.}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))).(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). 50S subunit precursor C-CP_YjgA_(L22)-~H61; 23S ribosomal RNA 9h3q B 120 4.02 RF00001 39794318 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((.(((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))).)). 50S subunit precursor C-CP_YjgA_(L22)-~H61; 5S ribosomal RNA 9h3r A 2576 4.12 RF02540,RF02541,RF02543,RF00002 39794318 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagcagguugaagguuggguaacacuaacuggaggaccggggguaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaaggguaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacgccgugaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<...................>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<<<<..>>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<.......>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.........<<<<...<<<<<<......>>>>>>....>>>>...<<<..>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<...>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<......<<<.........>>>.............<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<......>>>>>>>>....>>>>>><<<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>.>>.....>>>>>>..............<<<<<<.......>>>>>>.<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....[[....>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>...........<<<<<<<<........<<.....>>..............<<<...<<<<.....>>>>...>>>..............>>>>>>>>..................<<<<<........>>>>>..<<<<<<<<.(((.........<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<..<.........<<<<<..<<.......<<<<<<<<....>>>>>>>>....>>............>>>.>>>.>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>........<<<..<<<<<<<...<<.......>>...>>>>>>>...>>>.........<<<<<..<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>......>>>.>>....<<<<<<......>>.>>>>........)))>>>>>>>>....<<<<<<<...<<<<...<<<<<<.....<....>....>>>>>>..<<<<<...<<<<...<<<<<<<<<<<.]].>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<.....<<<......>>>....>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....)))))))..((((((((.........))))))))..))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.(((.(.....(((.(((((((((.(((...(((((......)))))[[......(((.....]])))...)))...))))))))).)))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((.(..).)))))..))))...(.(........).).((((((....(((((((((((((..((....((.....))....))...((....))..(((.......))).....)))))))))))))..((.(...((((((.........(((....((((.(......).)))).....))).(.(((..)))...)..))))))......).))..((((((....(((((....)))))..(((((((..((((((((((.....(((...(((.((((...(.()..)...)))).)))..)).).....)))))).)))..)))))))).....((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{.(((((.(........................).......(((......)))..)))))...)))..))))).))...........]]].)...))))))))))...)))))))((((((.((....)).))))))....))))))(.(((((...(((......((.((((......)))).))...)))..)))))..).....))))))(.............((((((.......))))))(.((....((((..((..(((((.(...((.....)).).))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((.(((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..(((....((((((((((((.((.....))))))))))..))))..[.)))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))).))).))).))).....((......)).)))).((((.....))))..)).)..........((((((((.(.....(((.....)))....(..(.....((.....(((....]))).....))...)..).....).))))))))............)).[..(((((......].)))))..((((((((.(((..(......((((.((((((..(((((.((..(((((.(((((((.(((.(.(............(...(..(((.......(.(..((....))..).)....)))............)....)..))..))).)))))))...((..((((((.....)))))).))....)))))..))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))....(.(((((...((((((...((.......))...))))))....))).).)...).((.((.((.(((..((((((((........)))))..))).(((((.....))))).....))).)..)...))..))....(((((........).)))).....)..)))))))))))[...(((((((...((((..(.(((((.....(....)....))))).).(((((...(((....((((.((((((}}}.))))))...))))....))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). 50S subunit precursor C-CP_YjgA_(L22)-; 23S ribosomal RNA 9h3r B 120 4.12 RF00001 39794318 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). 50S subunit precursor C-CP_YjgA_(L22)-; 5S ribosomal RNA 9h3s A 2715 4.16 RF02540,RF02541,RF02543,RF00002 39794318 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugucgaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaaggguaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcaaaggaguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<<<<..>>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<...>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<.........>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<.<<....>>.>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<....<<..>>.....>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..............>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<.<<<<<...........<<<<<..<<.......<<..<<<......>>>..>>....>>............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>........<<<<.<.<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>...>...>>>.>.....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[......(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((((..)))))))..))))...(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(.....)...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{..(.((.(.......(.......)........).......(((......)))..)).)....)))..))))).))...........]]].)...))))))))))...)))))))((((((.(......).))))))....))))))(.(((((...(((......((.(((((....))))).))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(....).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...............)).))))))).)..))).)))))))).)))))).....)).[..(((((......].)))))..((((((((.(((.((......((((.((((((..(((((.((..(((((.((((((((((.(..((...............(............(..(((......)))..)...................)......))...)))))))))))...(((.((((((.....)))))))))....)))))..))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..)))))).......((((.(.((((((...((.......))...))))))...)))).)........((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(.(((((.....(....)....))))).).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). 50S subunit precursor C-CP_YjgA_L22; 23S ribosomal RNA 9h3s B 120 4.16 RF00001 39794318 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((.(((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))).)). 50S subunit precursor C-CP_YjgA_L22; 5S ribosomal RNA 9h3v A 2490 3.55 RF02540,RF02541,RF02543,RF00002 39794318 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcgucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuuggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaaggugucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<....<<<..<<<<<<<<<<<<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<..>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>>.>>...............<<....>>....>>.........<<<<.....>>>>.............>....>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>...>.>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<......<<...<<<.<<<..>>>.>>>..>>.......>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<..>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<..<<....>>..>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....[[[...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<..>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<.<<...<<<<...<<<<.<<<.<<<<<.<<<<<<<<<...<<<............<<<<<...<<.......<<<..<......>..>>>....>>.............>>>>>...>>>..>>.>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>...<<<.......>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>...>>..>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]].>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....(((((((..(((]]]..].)))......)))))))...)))....(((....)))((((((......)))))).(((((((((.........))))))))).))...((((((.....(..)......))))).).........((....))...(((((.....((.....))....)))))...((((.((((......(((.(((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...))))))))).)))...))))...)....((((..(...[........).))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((......)))))..))))...(.(........).).((((((....(((((((((((((..((....((.....))....))...((....))..(((.......))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((.(....).))).((((((((..((((((((((.....(((...(((.(((()))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(.().)..))))).))...........]]].)...))))))))))...)))))))((((((.((....)).))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..(((((.((((((...{{{.).))))).((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((.(((.].((.........))...(((((((.....(((....))).......))))))).}((((..))))...)).).))))).)..))).)))))))).)))))).....)).[..(((((......].)))))..((((((((.(((.((...((((...((((..((.(((((.(((((((.(...((..............((((...((.......((....(....)....))....)).............)))).....))..)..)))))))...(((.((((((.....)))))))))....))))).))...))))...(((.......)))((((((...........))))))([((...(((((((...((((((.......)))))).......][.[[[......)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....((.((((.((..]]]]..)))))).)).....)}......))))...))..)))))))))))[...(((((((...((((..(.(((((.....(....)....))))).).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). 50S subunit precursor C-CP_L2-L28; 23S ribosomal RNA 9h3v B 119 3.55 RF00001 39794318 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<<.....<<<<<<<<....<<<.<<<.............>>>...>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>> ((((((((((.....((((((((....((((.((...(.....)...)).)..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))) 50S subunit precursor C-CP_L2-L28; 5S ribosomal RNA 9h3w A 2650 5.38 RF02540,RF02541,RF02543,RF00002 39794318 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggcuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggagucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<......<<..<<<<<<<<<<<<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<......<<<<<<<<<<<<<.<<<....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>>.>>...............<<....>>....>>.........<<<<.....>>>>...................>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<.......>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<..<<<<<........>>>>>.>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<.<.....<<...<<<.<<<<...<<<<..>>.>>...>>>>.>>>..>>.......>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<...>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><<<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>.>>.....>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<.<..<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....[[[...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>>...<<<<<....>>>>>....>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<..<<....>>...>>>>>........>>>>>>>>..>>>>><<<<<.........>>>>>........<...............>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.<<<.<<<....<<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<<<<<...<<......<<<<..<<....>>..>>>>...>>.............>>>>>...>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>>..>>>...>>>>>>>>>>>....<<<<<<<...<<<<...<<<<<<...............>>>>>>..<<<<<...<<<<...<<<<.<<<<<<]]].>>>>>>...>>>>...>>>>.>>>>>...<<<.....<<<<...........>>>>.....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((......((..((((((((.((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))((((.((....)).))))..((((((((.........))))))))..))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......((((((((((.((.(((...(((((......)))))[[(...).(((.....]])))...)))...)).))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......))..)))))).))...............((....))....))......(..((((.....))))............)......)))))))))).....(.((((..((((........))))..))))...(.(........).).((((((....(((((((((.(((..((....((.....))....))...((....))..(((.......))).....))).)))))))))..((.(...((((((.....((((((((((.(.(....((((.(......).))))....[).)...((..(((((........))))).))..).))))))))).(.((.......))...)..))))))......).))..((((((....((((......))))..(((((((..((.((((((.(....(((...(((.((((...((((())).))...)))).)))..)).).....)))))).).)..)))))))).....(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(.....)..))))).))...........]]].)...))))))))))...)))))))((((.(.((....)).).))))....))))))(.(((((...(((......((.(((((....))))).))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(.(((.(((...(((....)))...)))..))))...((((........)))).]]((((((((((.((...(.((....((((..(((..(((((.((((((...{{{.).))))).((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....)).)...)).....)))))))))).))).))).....((......)).)))).(((.......)))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((......((....(((....])))....))....))))))(...).......(((((.(((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..((((((...(((.........((((..((....))...)))).........))).))))..)))))(((.............)))........((...........)..)....))))...)).).))))).)..))).)))))))).)))))).....)).[..(((((......].)))))..((((((((.(((.(((.....((((.((((((..(..((.((..(((((.(((((((((((..(...(.........(.(((..(.(......(((((.((....))).))))...)).............))).))...)..)))))))))))...(((.((((((.....)))))))))....)))))..))..))..)..(((......[)))((((((..........])))))).[((....((((((...(((((.........))))).....((][.[[[))....))))))....((((..((((..{.))))..)))).(((....))).))]]].].....(((((.(.((..]]]]..))).)))))......}......))))..))))))...)))...)))))))))))[...(((((((...((((.....(..(.....(....).....).)....(((((...(((....(((((((((((}}}.))))))..)))))....))).)))))...(((....((((.............))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). 50S subunit precursor C-CP_H68; 23S ribosomal RNA 9h3w B 119 5.38 RF00001 39794318 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<...<...<<<<<<<<...>>>>>>>>.....>.>>...>>>>>>>>>> ((((((((((.....((((((.(....(.(.(((...(.....)...)))...).)...).)))).)).((.......((((((((...)))))))).......))...)))))))))) 50S subunit precursor C-CP_H68; 5S ribosomal RNA 9h3x A 2637 4.12 RF02540,RF02541,RF02543,RF00002 39794318 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcgucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggagucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<......<<..<<<<<<<<<<<<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<......<<<<<<<<<<<<<.<<<....<<<<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>>.>>...............<<....>>....>>.........<<<<.....>>>>...................>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<.......>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<..<<<<<........>>>>>.>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<.<.....<<...<<<.<<<<.....>>>>.>>>..>>.......>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<..>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><<<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>.>>.....>>>>>>.......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<.<..<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....[[[...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<.......>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<..<<....>>...>>>>>........>>>>>>>>..>>>>><<<<<.........>>>>>........<...............>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>...........<<<<<........>>>>>..<<<<<<<<.<<<.<<<....<<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<<<<<...<<......<<<<..<<....>>..>>>>...>>.............>>>>>...>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>>..>>>...>>>>>>>>>>>....<<<<<<<...<<<<...<<<<<<...............>>>>>>..<<<<....<<<<...<<<<.<<<<<<]]].>>>>>>...>>>>...>>>>..>>>>...<<<.....<<<<...........>>>>.....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((......((..((((((((.((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))((((.((....)).))))..((((((((.........))))))))..))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......((((((((((.((.(((...(((((......)))))[[(...).(((.....]])))...)))...)).))))))))))...))))...)....((((.(((..[......))).))))......(((((].[[[[)))))..)))......))..)))))).))...............((....))....))......(..((((.....))))............)......)))))))))).....(.((((..((((........))))..)))).[.(.(........).).((((((....(((((((((((((..((....((.....))....))...((....))..(((.......))).....)))))))))))))..((.(...((((((.....((((((((((.(.(....((((.(......).))))....[).)...((..(((((........))))).))..).))))))))).(.((.......))...)..))))))......).))..((((((....((((......))))..(((((((..(((((((((.(....(((...(((.((((.....)))).)))..)).).....)))))).)))..)))))))).....((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..((..))..))))).))...........]]].)...))))))))))...)))))))((((.(..(....)..).))))....))))))(.(((((...(((......((.(((((....))))).))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(.(((.(((...(((....)))...)))..))))..(((((........)))))]]((((((((((.((...(.((....((((..(((..(((((.((((((...{{{.).))))).((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....)).)...)).....)))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((......((....(((....])))....))....))))))(...).......(((((.(((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..((((((...(((.........(((...((....))....))).........))).))))..)))))(((.............)))........((...........)..)....))))...)).).))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.(((.....((((.((((((..(.(((.(((.(((((.(((((((((((..(...(.........(.(((..(.(......(((.(.((....)))..)))...)).............))).))...)..)))))))))))...(((.((((((.....)))))))))....))))).)))..))).)..(((......[)))((((((..........])))))).[((....((((((...(((((.........))))).....((][.[[[))....))))))....((((..((((..{.))))..)))).(((....))).))]]].].....((.(.((.((..]]]]..))).)).))......}......))))..))))))...)))...)))))))))))[...(((((((...((((.....((.(.....(....).....)))....(((((...(((....(((.(((((((}}}.))))))..).)))....))).)))))...(((....((((.............))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). 50S subunit precursor C-CP_H68_L35; 23S ribosomal RNA 9h3x B 119 4.12 RF00001 39794318 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<...<...<<<<<<<<...>>>>>>>>.....>.>>...>>>>>>>>>> ((((((((((.....((((((((....(.(.(((...(.....)...)))...).)...)))))).)).((.......((((((((...)))))))).......))...)))))))))) 50S subunit precursor C-CP_H68_L35; 5S ribosomal RNA 9h3y A 2895 3.09 RF02540,RF02541,RF02543,RF00002 39794318 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaugucgaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccgggagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<<<<..>>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>...>.>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<...>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<.........>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<.<<....>>.>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<....<<..>>.....>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<<.<<....>>..>>>>>>........>>>>>>>>..>>>>><<<<<.........>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<..<<<<...........<.<<<..<<.......<<..<<<......>>>..>>....>>............>>>.>..>>>>..>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.........<<<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>>..>...>>>.......<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((((.(((...(((((......)))))[[......(((.....]])))...)))...)))))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((((..)))))))..))))...(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(..(...)...)...)))).)))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{..(.((.(........................).......(((......)))..)).)....)))..))))).))...........]]].)...))))))))))...)))))))((((((.(......).))))))....))))))(.(((((...(((......((.(((((....))))).))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..(((((.((((((...{{{.).))))).((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((.(((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).).))))).)..))).)))))))).)))))).....)).[..(((((......].)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.((((((((((.(..((...............(............(..(((......)))..)...................)......))...)))))))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..)))))).......((((....(((((...((.......))...))))).....))).)........((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(.(((((.....(....)....))))).).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). 50S subunit precursor 50S_(L16)-; 23S ribosomal RNA 9h3y B 120 3.09 RF00001 39794318 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((.(((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))).)). 50S subunit precursor 50S_(L16)-; 5S ribosomal RNA 9h3z A 2900 2.98 RF02540,RF02541,RF02543,RF00002 39794318 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<<<<..>>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>...>.>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<........>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<.........>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<.<<....>>.>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<<.<<....>>..>>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<.<<<<<...........<.<<<..<<.......<<..<<<......>>>..>>....>>............>>>.>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>........<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>.....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((.(((.(((...(((((......)))))[[......(((.....]])))...)))...))).)))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((((..)))))))..))))...(.(........).).((((((....(((((((((((((..((....((.....))....))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...((..((((...(...............)...))))..))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{..(.((.(........................).......(((......)))..)).)....)))..))))).))...........]]].)...))))))))))...)))))))((((((.(......).))))))....))))))(.(((((...(((......((.(((((....))))).))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..(((((.((((((...{{{.).))))).((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((.(((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).).))))).)..))).)))))))).)))))).....)).[..(((((......].)))))..((((((((.(((.((......((((.((((((..(((((.((..(((((.(((((((.((.(..(................(............(..(((......)))..)...................).......)...))).)))))))...(((.((((((.....)))))))))....)))))..))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). mature 50S subunit; 23S ribosomal rRNA 9h3z B 120 2.98 RF00001 39794318 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). mature 50S subunit; 5S ribosomal RNA 9h82 E 22 7.29 32630 aucuucuucgauuucuuccauc ...................... ...................... Small circular RNA dimer - Class 1; RNA (5'-R(P*AP*UP*CP*UP*UP*CP*UP*UP*CP*GP*AP*UP*UP*UP*CP*UP*UP*CP*CP*AP*UP*C)-3') 9h82 B 36 7.29 32630 uggaagaaaucgaagaagaugaagaacgcgaagaac .................................... .................................... Small circular RNA dimer - Class 1; RNA (36-MER) 9h83 A 16 7.8 32630 uggaagaaaucgaaga ................ ................ Small circular RNA dimer - Class 2; Complementary strand 9h83 D 21 7.8 32630 aucuucuucgauuucuuccuc ..................... ..................... Small circular RNA dimer - Class 2; Circular RNA 9h83 C 36 7.8 32630 aucuucuucgauuucuuccaguucuucgcguucuuc .................................... .................................... Small circular RNA dimer - Class 2; Circular RNA 9h83 B 36 7.8 32630 uggaagaaaucgaagaagaugaagaacgcgaagaac .................................... .................................... Small circular RNA dimer - Class 2; Complementary strand 9h86 A 36 9.3 32630 uggaagaaaucgaagaagaugaagaacgcgaagaac .................................... .................................... Small circular RNA dimer - Class 4; Complementary strand 9h86 D 36 9.3 32630 aucuucuucgauuucuuccaguucuucgcguucuuc .................................... .................................... Small circular RNA dimer - Class 4; Circular RNA 9h86 C 36 9.3 32630 aucuucuucgauuucuuccaguucuucgcguucuuc .................................... .................................... Small circular RNA dimer - Class 4; Circular RNA 9h86 B 36 9.3 32630 uggaagaaaucgaagaagaugaagaacgcgaagaac .................................... .................................... Small circular RNA dimer - Class 4; Complementary strand 9h86 E 36 9.3 32630 uggaagaaaucgaagaagaugaagaacgcgaagaac .................................... .................................... Small circular RNA dimer - Class 4; Complementary strand 9h86 H 36 9.3 32630 aucuucuucgauuucuuccaguucuucgcguucuuc .................................... .................................... Small circular RNA dimer - Class 4; Circular RNA 9h86 G 36 9.3 32630 aucuucuucgauuucuuccaguucuucgcguucuuc .................................... .................................... Small circular RNA dimer - Class 4; Circular RNA 9h86 F 36 9.3 32630 uggaagaaaucgaagaagaugaagaacgcgaagaac .................................... .................................... Small circular RNA dimer - Class 4; Complementary strand 9h8a A 36 9.6 32630 uggaagaaaucgaagaagaugaagaacgcgaagaac .................................... .................................... Small circular RNA dimer - Class 5; Complementary strand 9h8a D 36 9.6 32630 aucuucuucgauuucuuccaguucuucgcguucuuc .................................... .................................... Small circular RNA dimer - Class 5; Circular RNA 9h8a C 36 9.6 32630 aucuucuucgauuucuuccaguucuucgcguucuuc .................................... .................................... Small circular RNA dimer - Class 5; Circular RNA 9h8a B 36 9.6 32630 uggaagaaaucgaagaagaugaagaacgcgaagaac .................................... .................................... Small circular RNA dimer - Class 5; Complementary strand 9h8a E 36 9.6 32630 uggaagaaaucgaagaagaugaagaacgcgaagaac .................................... .................................... Small circular RNA dimer - Class 5; Complementary strand 9h8a H 36 9.6 32630 aucuucuucgauuucuuccaguucuucgcguucuuc .................................... .................................... Small circular RNA dimer - Class 5; Circular RNA 9h8a G 36 9.6 32630 aucuucuucgauuucuuccaguucuucgcguucuuc .................................... .................................... Small circular RNA dimer - Class 5; Circular RNA 9h8a F 36 9.6 32630 uggaagaaaucgaagaagaugaagaacgcgaagaac .................................... .................................... Small circular RNA dimer - Class 5; Complementary strand 9ha4 B 119 4.26 RF00001 39794318 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggca <<<<<<<<<<.....<<<<<<<<....<<<.<<<.............>>>...>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>> .(((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))))). Pooled 50S subunit C-CP_(L22)- precursor states supplemented with Api137; 5S ribosomal RNA 9ha4 A 1977 4.26 RF02540,RF02541,RF02543,RF00002 39794318 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaccgggagauagcugguucuccccgaaagcuauauaaguagcgccucgugaauucaucuccggggguagagcaccaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagaagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaaguccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaaaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<....<<<..<<<<<<<<<<<<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<...........>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>>.>>...............<<....>>....>>.........<<<<.....>>>>.............>....>>>>>>>>>>>.......<<<<..<<<<<......>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>....<<...>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>..<<<<<<<...<<<<<<<<<.....<<<.......>>.>.....>>>>>>.>>>...>>>>>>>.....<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<..>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>><<<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>.>>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<..<<<<....>>>.>.>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<.....<<<<....<<<<..<<<..<<<<<<<<<<<....[[[...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>.........>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>...<<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>.............>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>................>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]].>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<.............>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....(((((((..(((]]]..].)))......)))))))...)))....(((....)))((((((......))))))..((((((((.........))))))))..))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.(((.(.....(((((((((.(((.(((...(((((......)))))[[(...).(((.....]])))...)))...))).)))))))))...))))...)....((.(((.............))).))......(((((..[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((...((((......))))...))))...(.(........).).((((((....(((((((((((((..(((...((.....))...)))...(.(...))..((((.....)))).....)))))))))))))..((.(...((((((.))))))......).))..((((((....(((((....)))))..(((((((..((((((((((.....(((.......)).).....)))))).)))..)))))))).....((((((((.(......).))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....(..)...........]]].)...))))))))))...)))))))((((.((((....)))).))))....))))))(.(((((....((......((.(((((....))))).))...))...)))))..).....))))))(.......(.....((((((.......))))))((((....((((..((.([((((((...((.....)).)))))))...[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((.(....(.((...((((..(((..(((((.((((((...{{{.).))))).(...((((...(((.((((.(((.((.....))))).))))...)))..{))))....)(..(((((....)))))...))))))...)))...))))(..).....)).)...).....))))))))))).))).]))......(......)..)))).((((.....))))..))))..(((((((.....(((...(((((..)}))))...)))...))))))(...).......))......)).[..(((((......].)))))..((((((((.((((((((...........))))))([.(...(((((((...(((((.........))))).....((][.[[[))....)))))))...(.((..((((..{.))))..)).).(((....))).).]]].].....((((.((.((..]]]]..))).))))).....)}.........))))))))))[...(((((((...((((..(.(((((.....(....)....))))).).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....(..(.............)..)....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Pooled 50S subunit C-CP_(L22)- precursor states supplemented with Api137; 23S ribosomal RNA 9ha6 B 120 3.08 RF00001 39794318 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...)))))))))). mature 50S subunit supplemented with Api137; 5S ribosomal RNA 9ha6 A 2900 3.08 RF02540,RF02541,RF02543,RF00002 39794318 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaauguugaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucacgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccugcccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaagacggaaagaccccgugaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucacauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>.............}....>>>>>>>>>>>.......<<<<..<<<<<<<..>>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>...>.>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<........>>.>>...>>>>.>>>..>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<.........>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<.<<....>>.>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<........<<<<<<.<<....>>..>>>>>>........>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<.<<<<<...........<.<<<..<<.......<<..<<<......>>>..>>....>>............>>>.>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>........<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>.....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((.(((.(((...(((((......)))))[[......(((.....]])))...)))...))).)))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((((..)))))))..))))...(.(........).).((((((....(((((((((((((..((....((.....))....))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...((..((((...(...............)...))))..))..)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{..(.((.(........................).......(((......)))..)).)....)))..))))).))...........]]].)...))))))))))...)))))))((((((.(......).))))))....))))))(.(((((...(((......((.(((((....))))).))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..(((((.((((((...{{{.).))))).((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((.(((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).).))))).)..))).)))))))).)))))).....)).[..(((((......].)))))..((((((((.(((.((......((((.((((((..(((((.((..(((((.(((((((.((.(..(................(............(..(((......)))..)...................).......)...))).)))))))...(((.((((((.....)))))))))....)))))..))..)))))..(((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......(((((.(.((((((...((.......))...))))))...)))).).)......((((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))).).....(((((((....))).))))....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). mature 50S subunit supplemented with Api137; 23S ribosomal rRNA 9ha7 B 120 4.37 RF00001 39794318 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcaa <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((.(((((((.....((((((((....(((((((...(.....)...))))..)))...)))))).)).((.......((((((((...)))))))).......))...))))))).)). Pooled 50S subunit C-CP_(L22)-~H61 precursor states supplemented with Api137; 5S ribosomal RNA 9ha7 A 1988 4.37 RF02540,RF02541,RF02543,RF00002 39794318 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcaccaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacagguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaaugucuccacccgagacucagugaaauugaacucgcugugaagaugcaguguacccgcggcaaggacuggggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccggggauaaaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<....<<<..<<<<<<<<<<<<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>>.>>...............<<....>>....>>.........<<<<.....>>>>.............>....>>>>>>>>>>>.......<<<<..<<<<<<<..>>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<..<<<<<<<.>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<.......>>.>.....>>>>>>.>>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<..>...........))).....>>>>>>.>>>...>>>>>>><<<<<<.<<....>>.>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>..>.....>>>>>><.............<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<..{..>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<.<<...<<<<....<<<<..<<<..<<<<<<<<<<<....[[[...>>>>>><<..<<<....<<<<<<<<<<<<.<<.....>>>>>>>>>>.>>.>>....>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>.....>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..}.......<<<<<<<...<......>...>>>>>>>............>.....<<<<<........>>>>>..<<<<<<<<.<<<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>................................>>>>>>>>>>....<<<<<<<...<<<.<..<<<<<<.....<....>....>>>>>>..<<<<<...<<<<...<<<<<<<<<<<]]].>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>.>>.<<<<<.....>>>>><....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>..>..>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....(((((((..(((]]]..].)))......)))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......(((((((((((.(.(((...(((((......)))))[[......(((.....]])))...)))...).)))))))))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..(((((((..)))))))..))))...(.(........).).((((((....(((((((((((((..(((...((.....))...)))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((.......)).).....)))))).)))..)))))))).)...((((((((((......))))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....(())...........]]].)...))))))))))...)))))))((((((.(......).))))))....))))))(.(((((...(((......((((((((....))))))))...)))..)))))..).....))))))(.............((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((...(((...(((....)))...)))...)))..(((((........)))))]](((.((((((.((...((((....((((..(((..(((((.((((((...{{..).))))).....((((...(.(.((((((((.((.....))))))))))..).)....)))).....(..(.(((....))))....))))))...)))...))))(..).....))))...)).....)))))).))).))).))).....((......)).)))).((((.....))))..))))..(.......(((((((..((......))..)))))))....).......)).[..(((((......].)))))..((((((((.(((((......[)))((((((..........]))))))([((...(((((((.(.(((((.........)))))...).((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}.........................))))))))))[....((((((...(((.(.(.(((((.....(....)....))))).).(((((...((((...(((((((((((.}}.))))))..)))))...)))).)))))...(((....((((.............))))....))).))))..]....)))))).(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Pooled 50S subunit C-CP_(L22)-~H61 precursor states supplemented with Api137; 23S ribosomal RNA 9iiy B 22 3.0 39814893 9606 uagcagaucgguuguauagacg ...................... ...................... Cryo-EM Structure of EfPiwi-piRNA-target (25-nt, bilobed); RNA (5'-R(P*UP*AP*GP*CP*AP*GP*AP*UP*CP*GP*GP*UP*UP*GP*UP*AP*UP*AP*GP*AP*CP*G)-3') 9iiy C 21 3.0 39814893 9606 cgucuauacaaccgaucagcu ..................... ..................... Cryo-EM Structure of EfPiwi-piRNA-target (25-nt, bilobed); RNA (5'-R(P*CP*GP*UP*CP*UP*AP*UP*AP*CP*AP*AP*CP*CP*GP*AP*UP*CP*AP*GP*CP*U)-3') 9iiz B 25 3.8 39814893 9606 uuaccaucaacauggaaacuuggcu ......................... ......................... Cryo-EM Structure of EfPiwi-piRNA-target (25-nt, comma); RNA (25-MER) 9iiz C 24 3.8 39814893 9606 agccaaguuuccauguugauggua ........................ ........................ Cryo-EM Structure of EfPiwi-piRNA-target (25-nt, comma); RNA (5'-R(P*AP*GP*CP*CP*AP*AP*GP*UP*UP*UP*CP*CP*AP*UP*GP*UP*UP*GP*AP*UP*GP*GP*UP*A)-3') 9ij0 B 19 3.2 39814893 9606 uuaccaucaacauggacun ................... ................... Cryo-EM Structure of MILI-piRNA-target (8-nt); RNA (26-MER) 9ij1 B 26 3.2 URS0000400A3F_9606 39814893 9606 uuaccaucaacauggaaacuuggcun .......................... .......................... Cryo-EM Structure of MILI-piRNA-target (22-nt, bilobed); RNA (26-MER) 9ij1 C 21 3.2 39814893 9606 caaguuuccauguugauggua ..................... ..................... Cryo-EM Structure of MILI-piRNA-target (22-nt, bilobed); RNA (5'-R(P*CP*AP*AP*GP*UP*UP*UP*CP*CP*AP*UP*GP*UP*UP*GP*AP*UP*GP*GP*UP*A)-3') 9ij2 B 22 3.9 39814893 9606 uuaccaucaacauggaaacuug ...................... ...................... Cryo-EM Structure of MILI-piRNA-target (22-nt, comma); RNA (5'-R(P*UP*UP*AP*CP*CP*AP*UP*CP*AP*AP*CP*AP*UP*GP*GP*AP*AP*AP*CP*UP*UP*G)-3') 9ij2 C 21 3.9 39814893 9606 caaguuuccauguugauggua ..................... ..................... Cryo-EM Structure of MILI-piRNA-target (22-nt, comma); RNA (5'-R(P*CP*AP*AP*GP*UP*UP*UP*CP*CP*AP*UP*GP*UP*UP*GP*AP*UP*GP*GP*UP*A)-3') 9ij3 B 26 2.6 URS0000400A3F_9606 39814893 9606 uuaccaucaacauggaaacuuggcun .......................... .......................... Cryo-EM Structure of MILI-piRNA-target (26-nt); RNA (26-MER) 9ij3 C 25 2.6 39814893 9606 gagccaaguuuccauguugauggua ......................... ......................... Cryo-EM Structure of MILI-piRNA-target (26-nt); RNA (25-MER) 9ij4 B 26 2.7 URS0000400A3F_9606 39814893 9606 uuaccaucaacauggaaacuuggcun .......................... .......................... Cryo-EM Structure of MILI(K852A)-piRNA-target (26-nt); RNA (26-MER) 9ij4 C 25 2.7 39814893 9606 gagccaaguuuccauguugauggua ......................... ......................... Cryo-EM Structure of MILI(K852A)-piRNA-target (26-nt); RNA (25-MER) 9ij5 B 26 2.8 URS0000400A3F_9606 39814893 9606 uuaccaucaacauggaaacuuggcun .......................... .......................... Cryo-EM Structure of MILI(K853A)-piRNA-target; RNA (26-MER) 9ij5 C 25 2.8 39814893 9606 gagccaaguuuccauguugauggua ......................... ......................... Cryo-EM Structure of MILI(K853A)-piRNA-target; RNA (25-MER) 9is7 A 123 2.87 39890981 2895524 agcaggcgccaccugcugcggaaccgcugaagccgcgugccucuaacagggcuggcgcggcuacgaagggcgcugggggugggaaccaccuccuucgacccaauccauggccacgacaaggag <<<<<<.....>>>>>>...........<.<<<<<<<<<<<<......>>>>..>>>>>>>>.>...<<<<<..<<<<<<<<...>>>>>>>>..>>.>>>......<<<>>>.......... ((((((.....))))))...........(.((((((((((((......))))..)))))))).)...(((((..((((((((...))))))))..)).)))......((())).......... Paracandidimonas lactea CP group II intron 2S state; RNA (153-MER) 9is7 B 582 2.87 39890981 2895524 gggcgacuacgaaacgggccuggguaggaaaugacccagugacccugacaguuugggaaagucggugaaagcccgacccucggggccuagcgaaagugggcgacgagugcaacaccuggaggcugagggcgucagugauggcgucaggcaugcgggagaaaucuaggcaugcuggcaccuaucgaaagauggggccgcuggauagcucaaucagguaaaggcaccguucaggugcuguguugaggcauaggaaggcagggccgcagucgcgguaagcaagcagcguugaagcgcaucggcaguaccgcauccguuauggaaccuugggagcgagaaacccuggaaacggggguagggucagagaccuagauaaauccgauguggccgagcuggcugucguucgaugccguaguacugacugucuaaguagggaaggucucggcagaucguggggguggcacccugcgaaauuaucugccaagacugggagauggcuugaguagugccgccgcgcgagcggugggcagaccaugggggcagacuugcuggauguuccuaucggcgaaagagccaagcgguaac ..((..<<<<.....<<<<<<<<<<........>>>>>>.>.>>>.<<<<<<<.<<....<<<<<.......>>>>>.<<<<..<<<<.<<....>>>>>>..>>>>..<<<<<<<<<<...<.<..<<<<<<<....>>>>>>>.<<<<<<<.<<<....>>>..>>>>>>><<<.<<<<<<....>>>>>>>>>.>.>....))....>>>>>....<<<<<<.....>>>>>>.>>>>>.<<<<<.<<<.<<<<<.<<<<......>>>>.((((((<<<<......<<<<<<<<<......<<<.<<<..............>>>>>>.....<<<<......>>>>...<<<<<...>>>>>........>>>>>>>.>>...>>>>.>>>>>.>>>.>>>>>......>>>>>>>>>...>>>>....<<<<<.<<<<<<<.<<<<<<......>>>>>>......>>>>>>>.>>>>>......<<<<<<.....<<<<<<<<<<....>>>>>.>>>>..<<.<<<<<<<<..))))))...>>>>>>>>..>>>....>>>>>>......... ..[[..((((.....((((((((((........)))))).).))).(((((((.((....(((((.......)))))(((((..((((.((....))))))..)))).)((((((((((...(.(..(((((((....)))))))...((((..(((....)))...))))..(((.((((((....))))))))).).)....]]....)))))....((((((.....)))))).))))).(((((.(((.(((((.(((........))).[[[[[[((((......(((((.(((......(((.(((..............)))))).....(((((....)))))...(((((...)))))........))).))).))...)))).))))).))).)))))......)))))))))...))))....(((((.(((((((((.((((......)))).)).....))))))).)))))......((((((.....((((((((((....))))).))))..((.((((((((..]]]]]]...))))))))..)))....))))))......... Paracandidimonas lactea CP group II intron 2S state; RNA (582-MER) 9j6p A 22 2.49 32630 ugcggggucccgggaggaccgc ...................... ...................... pre-mir-125a internal loop in complex with G-clamp; RNA (5'-R(P*UP*GP*CP*GP*GP*GP*GP*UP*CP*CP*CP*GP*GP*GP*AP*GP*GP*AP*CP*CP*GP*C)-3') 9j6p B 21 2.49 32630 gcggggucccgggaggaccgc ..................... ..................... pre-mir-125a internal loop in complex with G-clamp; RNA (5'-R(P*UP*GP*CP*GP*GP*GP*GP*UP*CP*CP*CP*GP*GP*GP*AP*GP*GP*AP*CP*CP*GP*C)-3') 9jm0 E 58 2.7 URS0002616B7B_562 39395169 562 cccuuagcgagagguccucuggauguuguuucggcauccugcauugaaucugaguuac .........<<<<<.>>>>><<<<<<<.....>>>>>>>................... ........((((((.)))))((((((((...))))))))..)................ retron Ec86-effector fiber; RNA (82-MER) 9jm0 H 58 2.7 URS0002616B7B_562 39395169 562 cccuuagcgagagguccucuggauguuguuucggcauccugcauugaaucugaguuac .........<<<<<.>>>>><<<<<<<<...>>>>>>>>................... ........((((((.)))))((((((((...))))))))..)................ retron Ec86-effector fiber; RNA (82-MER) 9jm0 N 58 2.7 URS0002616B7B_562 39395169 562 cccuuagcgagagguccucuggauguuguuucggcauccugcauugaaucugaguuac .........<<<<...>>>><<<<<<<.....>>>>>>>................... ........((((.(.).)))((((((((...))))))))..)................ retron Ec86-effector fiber; RNA (82-MER) 9jm0 R 58 2.7 URS0002616B7B_562 39395169 562 cccuuagcgagagguccucuggauguuguuucggcauccugcauugaaucugaguuac .........<<<<...>>>><<<<<<<<...>>>>>>>>................... ........((((.(.).)))((((((((...))))))))..)................ retron Ec86-effector fiber; RNA (82-MER) 9kad A 14 NA 39807887 9606 gcagcagcagcagc .............. .............. Solution NMR structure of an RNA duplex containing pure CAG repeats; RNA (5'-R(*GP*CP*AP*GP*CP*AP*GP*CP*AP*GP*CP*AP*GP*C)-3') 9kad B 14 NA 39807887 9606 gcagcagcagcagc .............. .............. Solution NMR structure of an RNA duplex containing pure CAG repeats; RNA (5'-R(*GP*CP*AP*GP*CP*AP*GP*CP*AP*GP*CP*AP*GP*C)-3') 9mor 1 2903 2.65 RF02540,RF02541,RF02543,RF00002 39829893 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaacccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<....<<<..<<<<<<<<<<<<<......<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>>..<<<..<<<<......<<<<<<<<<<<<<.<<<...<<<<........>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>..>>>......>>.>>>>>>>.>>...............<<....>>....>>.........<<<<.....>>>>.............>....>>>>>>>>>>>........<<<..<<<<<<....>>>>>>..>>>....<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<<...<<<<<<......>>>>>>.>...>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>..<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<<<<<<.....>>>>>.>>...>>>>.>>>..>>.>.....>>>>>>>.>>...>>>>>>>.....<<<<<<<<<........>>>>>>>>>....<<<......>>>...<<<<.<<<....<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<...<<<<.......>>>>...>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>....>>>>>>><<<.<<<<<....>>>>>.>>>....>>>>>><.<<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>>.>>>>>..>.....>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....[[[...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<.....<..>......>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.......<<<<<<.<<....>>..>>>>>>.......>>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<.......>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<.<<<<.<<<.<<......<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<<...........<<<<<..<<<......<<<<<<<<....>>>>>>>>...>>>............>>>>>..>>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<.<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>.>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>>>>>>........<<<.<.<<<<<<...<<.......>>...>>>>>..>.>>>>.........<<<<<.<.<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>>>...>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>>>>>.>>>....<<<<<<<...<<<<....<<<<<.....<....>....>>>>>...<<<<<...<<<<...<<<<<<<<<<<]]].>>>>>>..>>>>>...>>>>.>>>>>....<<....<<<<<...........>>>>>....>>..>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((.......((((((((((....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.(((.......((((.((((((((.(((...(((((......)))))[[(...).(((.....]])))...)))...)))))))).))))....)))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............))....))))))))))......(.((.(...(((((....)))))...).)).[.(.(........).).((((((....(((((.(((.(.(..((....((.....))....))...((....))..(.(.....<.).).....).).))).)))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....((((......))))..(.(((((..((((((((((.....(((....((.((((...((.((.........))..))...)))).))...)).).....))))))).))..)))))).).....((((((((..........))))))))....(((......)))...((((.(((...((([[[.....((((((.....(.....((..(..((..(.(.....{.(((((.(((..((((.......))))..))).....(..(((......)))).)))))...).)..))..).))...........]]].)...)))))).)))...)))))))((.(...((....))...).))....))))))(.(((((...(((.......((.(((......))).))....)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((((((((((((...((((....((((..(((..((((((((((((...{{{.).))))))((..((((...(((.((((((((.((.....))))))))))...)))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))))))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((....(((....])))....)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((.........(.((..((....))...)).).........))))))))..)))))(((((.........)))))........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(.(((.....]}.))).)..(((.((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((.(.(..(.(.(..........((((..(.(......((((((((....))))))))...).)............)))).).).)..).).)))))))...(((.((((((.....)))))))))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...((.((((...(((((.........))))).....((][.[[[))....)))).))...((((...((...{..))..>)))).(((....))).))]]].].....((.(((..((..]]]]..)).))).)).....)}......))))..))))))......(.((..(.((((((...((.......))...))))))...).))...)......(.((.((((((..((((((((........)))))..))).(((((.....))))).....)))))..)...))..).....(.(((((....))).)).)....))..))))))).)))[...(((((((...((((..(..((((.....(....)....))))..).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))....((....((((.....}.......))))....))..))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Damaged 70S ribosome with PrfH bound; 23S ribosomal RNA 9mor 2 1534 2.65 RF00177,RF01959,RF02542,RF01960 URS000081169C_562 39829893 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugangucgnaacaagguaaccguaggngnnccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<......>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<..<..<<<<<......>>>>>.....>>>.>.....<<<....>>>....<<<<<<..<<....>>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<..[.>>>...>>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<.......<<<....>>>......>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<......<.)))>........>>>>>>>>>>..>>>>>>>>>.......]..<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<..<<<<<<<.<<.<<<<<...<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<...<<<<<<....>>>>>>....<......>..>>>>>.>>..<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<<<..<<.......>>>>..>.>>>>>>>.....<<<<<.....>>>>>........>>>>.........>>>...>>>>>>>>....>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>......>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>.>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ........((((..[.[[[[.)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((........))))).)))))..)))))......(((......(((((((..((...(.(((((.(.((.....((((.(....).))))......)).).....(((....)))....(((.((...(....).)).))).))))).)..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((.((......))....))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..(((........(((....))).......)))...(.(((((...(..(.((((((((.......)))))))).)...)....)))))....)..((((([[[...(((((.....(..]]].).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......(((.((.....)).)))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((.(((.....))).))))))))...((..]])).....)))))))))).(((......((((....))))....)))..]]]].]((((...(((.((.((..(((((..((((.(((((......((........))..........(((((((..(...((.((((....(((((....)))))...............))))..))).((.(((...((((((.(....((((((..(....).....(((......)))...)))))).....(((..(((((((...((..((.......))))....)))))))..(..(((((.....))))).....)...))).....).).)))...)).)))))....)))))))...)).))).)))).(...((((((......(((..((...(((....)))...))....)))......))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)).)))..)).))..(.(..((.(.((((.(((..((((((((((((....(((.(..(((...((....))..))).).)))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Damaged 70S ribosome with PrfH bound; 16S ribosomal RNA 9mor 4 120 2.65 RF00001 39829893 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<...............>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. .(((((((.(.....((.(((.(....(((((((...(.....)...))))..)))...).)))..)).((.......((.(((((...))))).)).......))...).))))))).. Damaged 70S ribosome with PrfH bound; 5S ribosomal RNA 9mor 5 77 2.65 RF00005 39829893 0030533 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Damaged 70S ribosome with PrfH bound; P-tRNA, E-tRNA 9mor 6 77 2.65 RF00005 39829893 0030533 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(((((.......)))))))))))..... Damaged 70S ribosome with PrfH bound; P-tRNA, E-tRNA 9mor 7 13 2.65 39829893 562 aaaauguucuaca ............. ............. Damaged 70S ribosome with PrfH bound; mRNA 9mq4 1 2903 2.78 RF02540,RF02541,RF02543,RF00002 39829893 0003735 0005840 562 gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgaugaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguuauaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuaucauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacaucuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcgagcgaacggggagcagcccagagccugaaucaguguguguguuaguggaagcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaugcacaugcugugagcucgaugaguagggcgggacacgugguauccugucugaauauggggggaccauccuccaaggcuaaauacuccugacugaccgauagugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagugaaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggcgugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguagcaagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggcguuaaguugcaggguauagacccgaaacccggugaucuagccaugggcagguugaagguuggguaacacuaacuggaggaccgaaccgacuaaunungaaaaauuagcggaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugguucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggguagagcacuguuucggcaagggggucaacccgacuuaccaacccgaugcaaacugcgaauaccggagaauguuaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaacaacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacgaugugggaaggcccagacagccaggauguuggcuuagaagcagccaucauuuaaagaaagcguaauagcucacuggucgagucggccugcgcggaagauguaacggggcuaaaccaugcaccgaagcugcggcagcgacgcuuaugcguuguuggguaggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagguaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagcccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcagggugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagguuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcuauguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuuccaggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggugcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucagguaacaucaaaucguaccccaaaccgacacngguggucagguagagaauaccaaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccguaacuucgggagaaggcacgcugauauguaggugaggucccucgcggauggagcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaacacagcacugugcaaacacgaaaguggacguauacggugugacgccuncccggugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacnauaacgguccuaagguagcgaaanuccuugucggguaaguuccgacnugcacgaauggcguaaugauggccaggcugucuccacccgagacucagugaaauugaacucgcugugnagaugcaguguacccgcggcaagacggaaagaccccgunaaccuuuacuauagcuugacacugaacauugagccuugauguguaggauaggugggaggcuuugaaguguggacgccagucugcauggagccgaccuugaaauaccacccuuuaauguuugauguucuaacguugacccguaauccggguugcggacagugucugguggguaguuugacugnggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauccuggucggacaucaggagguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcgagcaggugcgaaagcaggucauagugauccggugguucugaauggaagggccaucgcucaacggauaaaagguacuccgnggauaacaggcugauaccgcccaagaguucauaucgacggcgguguuuggcancucgnugucggcucaucacauccuggggcugaaguaggucccaaggguauggcnguucgccauuuaaagugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggaccggaguggacgcaucacugguguucggguugucaugccaauggcacugcccgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaacuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacguugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguugagcuaaccgguacuaaugaaccgugaggcuuaaccu <<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))..].>>>......>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>...[.....<<....>>..<<<<<<.....<<.....>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..)))....].]].>>>>>>>.]]...............<<....>>....]].........<<<<.....>>>>..................>>>>>>>>>>>.......<<<<..<<<<<<....>>>>>>..>>>>...<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<.....<<<...<<<.<<<<...<<.<<<<.....>>>>..>>...>>>>.>>>..>>.>.....>>>>>>>.>>...>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<..<<<<<..<<........<<<<<.<<<..<<<<.......>>>>..>>>........<<<......>>>..>>>>>....>>..>>>>>.>>...........))).....>>>>>>.>>>...>>>>>>><<<<<<<<<....>>>>>>>>>....>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...............>>>>><<<<<<.....<<<...<<<<.....>>>>...>>>...>>>>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<....<...<<<<<<.<<....>>..>>>>>>..>.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<...........<<<<<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<<<.<<<............<<<<<..<<.......<<<<<<<<....>>>>>>>>....>>............>>>>>...>>>.>>>>>>>>>>>...<<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>...>>...>>>>>.>>>.....>>.....>>>>>>>>. ((((((((......((((((((((.....(((..(((((((((((((......((((((.[..[[[.))).....((((((...(((]]]..].))).......))))))...)))....(((....)))(((((((....))))))).(((((((((.........))))))))).))...((((((.....(...[..)......))))).).........((....))...(((((.....((.]...))....)))))...((((.((((......((((.(((((.((.(((...(((((......)))))[[(...).(((.....]])))...)))...)).))))).))))...))))...)....((((((((..[......))))))))......(((((].[[[[)))))..)))......)).))))))).))...............((....))....))......(..((((.....))))............)).....)))))))))).....(.((((..((((((....))))))..)))).[.(.(........).).((((((....(((((((((((((..((....((.....))....))...((....))..((((.....)))).....)))))))))))))..((.(...((((((.....((((((((((.((((...((((((......))))))...)[)))...(((.(((((........))))))))..).))))))))).(.(((.....)))...)..))))))......).))..((((((....(((((....))))).((((((((..((((((((((.....(((...(((.((((...(((.(.........).).))...)))).)))..)).).....)))))).)))..)))))))).)...(((((((((........)))))))))....(((......)))...((((.(((...((([[[...(.((((((.....(.....((..(((((..(((.....{...(((.(((..((((.......))))..))).....(..(((......)))).))).....)))..))))).))...........]]].)...))))))))))...)))))))(((((..((....))..)))))....))))))(.(((((...(((......(((((((......)))))))...)))..)))))..).....))))))(......((.....((((((.......))))))((((....((((..((..(((((((...((.....)).))))))....[[(((.(((.(.(((...(((....)))...)))..))))..(((((........)))))]](((.(((((((((...((((....((((..(((..(((((.((((((...{{{.).))))).((..((((...((((((((((((.((.....))))))))))..))))..[))))...))(..(((((....)))))...))))))...)))...))))(..).....))))...))....))))))).))).))).))).....((......)).)))).((((.....))))..))))..((((....((((((((.((..(....(.......(((((....(.{..).....)))))((((((.....(((...((((....]))))...)))...))))))(...).......(((((((((.].((.........))...(((((((.....(((....))).......))))))).}((((.(((..(((((((..(((........(((((..((....))...)))))........))))))))..)))))(.(((.........))).)........((..........(((((.......)))))..)..)....))))...)).))))))).)..))).)))))))).)))))).....)).{..(((((.....]}.)))))..((((((((.(((.((......((((.((((((..(((((.(((.(((((.(((((((.(.(..(.(.(..........((((..(((......(((.((((....)))).)))...)))............)))).).)..).).).)))))))...(((..(((((.....))))).)))....))))).)))..)))))..(((......[)))((((((..........]))))))([((...(((((((...(((((.........))))).....((][.[[[))....)))))))...((((..((((..{.))))..)))).(((....))).))]]].].....(((((((.((..]]]]..))))))))).....)}......))))..))))))......((((..(.((((((...((.......))...))))))...).)).).)......(.((.((((((..(((((((((......))))))..))).(((((.....))))).....)))))..)...))..).....(.(((((....))).)).)....))..)))))))))))[...(((((((...((((..(((((((.....(....)....))))))).(((((...((((...(((((((((((}}}.))))))..)))))...)))).)))))...(((....((((.....}.......))))....))).))))..]....)))))))(.((((((..).)))))(....((..(((((.......)))))....((((((((..((....(((((....)))))...))...))))).))).....))..).))))))))). Damaged 70S ribosome with PrfH bound; 23S ribosomal RNA 9mq4 2 1534 2.78 RF00177,RF01959,RF02542,RF01960 39829893 0003735 0005840 562 aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacgaguggcggacgggugaguaaugucugggaaacugccugauggagggggauaacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagagggggaccuucgggccucuugccaucggaugugcccagaugggauuagcuaguaggugggguaacggcucaccuaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaacugagacacgguccagacuccuacgggaggcagcaguggggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuucggguuguaaaguacuuucagcggggaggaagggaguaaaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcuaacuccgugccagcagccncgguaauacggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucucguagagggggguagaauuccagguguagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacgccguaaacgaugucgacuuggagguugugcccuugaggcguggcuuccggagcuaacgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagcgguggagcaugugguuuaauucgaunnaacgcgaagaaccuuaccuggucuugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgugagacaggugcugcauggcugucgucagcucguguugugaaauguuggguuaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggccgggaacucaaaggagacugccagugauaaacuggaggaagguggggaugacgucaagucaucaugncccuuacgaccagggcuacacacgugcuacaauggcgcauacaaagagaagcgaccucgcgagagcaagcggaccucauaaagugcgucguaguccggauuggagucugcaacucgacuccaugaagucggaaucgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuuguacacaccgnccgunacaccaugggaguggguugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugugauucaugacuggggugaagucgnaacaagguaaccguaggngnnccugcgguuggauca ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.<<<..<<<..<<.<...<<<<<<<<<......>>>>>>.>>>.>..>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<......>>>>>......>>.>.....<<<....>>>....<<<<<<..<......>>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<......<<<<....>>>>.....>>>>...<.<<<<<......<.<<<<<<<<.......>>>>>>>>.>........>>>>>....>..<<<<<(((...<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<<<<<<<.....>>>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>..........<<<<<<<......<<<<<<<......<<<....>>>.................>>>>>.>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<..<<<<<<<...<<..<<<.....>>>>>....>>>>>>>.....<<<<<.....>>>>>.........>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<...<<<....>>>...>>....>>>.....>>>>>>>......<....<<<<<<<........>>>>>>>....>.....>>>>>>....<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.<<<<..<<....>>.>>>>>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>...... ........((((..[.[[[[.)))).((((.(((((..(((((((((....(((.(((..(((..((.((..((((((((........))))).)))))..)))))......(((......(((((((..((...(((((((.(.((.....((((((....))))))......)).).....(((....)))....((((((..((....)))))))).)))))))..)).)))))))(((....(((..((((((((.......)))))))))))......)))..((((((((....))))...))))))).(((((............))))).((((....))))...)))))).).....(.(((...(((((....)))).))))).)).))))))..((((......((((....)))).....))))...(.(((((...(...(((((((((.......)))))))).)...)....)))))....)..((((([[[...(((((.....((.]]])).......))))))))))..)))))))))..........((([[...(.((((...(((.(((((((.((((((((((......((((((.....))))))....))))))))..)))))))))..(((((((((...((((((((....(((((((...((........))......)))))))....).......((....)).)))))))..)))).))))..))))...))))....((((((...((...((((.........))))...))))))))......{...((((((..((((((((((((.....))))))))))))...((..]])).....)))))))))).(((......((((....))))....)))..]]]].](((((.(((((((.((..(((((..((((((((((......((........))........(.(((((((..(...(((((((...((((((....))))))..............))))).))).((.(((...((((((.(....(((((((((....)))...(((......)))...)))))).....(((..(((((((...((..(.(......))))....)))))))..(..(((((.....))))).....)...))).....).).)))...)).)))))....))))))))..)).)))))))).(...(((((((.....(((..((...(((....)))...))....))).....)))))))......(....(((((((........)))))))....)..)..))))).....(((((((.........)))))))......))...)))))))))).))..(.(..((.(.((((.(((..((((((((((((....((((((.((((..((....)).))))))))))...))))))))))))..))).))))..).))...)..)..(((((((((....)))))))))}..... Damaged 70S ribosome with PrfH bound; 16S ribosomal RNA 9mq4 4 120 2.78 RF00001 39829893 0003735 0005840 562 ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacucagaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgagaguagggaacugccaggcau <<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>.......>>...>>>>>>>>>>. ((((((((((.....((.(((((....(((((((...(.....)...))))..)))...)))))..)).((.......((((((((...)))))))).......))...)))))))))). Damaged 70S ribosome with PrfH bound; 5S ribosomal RNA 9mq4 5 77 2.78 RF00005 39829893 0030533 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((......[..)))).(((((.......))))).....(((((..]....)))))))))))..... Damaged 70S ribosome with PrfH bound; P-tRNA, E-tRNA 9mq4 6 77 2.78 RF00005 39829893 0030533 562 cgcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgucgguucaaauccggcccccgcaacca .<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<<<<.......>>>>>>>>>>>..... .((((((..((((.........)))).(((((.......))))).....(((((.......)))))))))))..... Damaged 70S ribosome with PrfH bound; P-tRNA, E-tRNA